“Self-targeting” module provides annotation of self-targeting spacers. ‘‘Self-targeting’’ is a phenomenon observed in the intracellular food-borne pathogen Listeria monocytogenes, which has been utilized as a genomic marker for screening CRISPR-Cas inhibitor genes.
116 self-targeting spacers detected out of 23,550 spacers from 330 CRISPR containing organisms reported in Stem et al (Trends Genet)
6,260 self-targeting events detected from 4,136 CRISPR containing organisms using the method as shown in the figure.