CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP045271	Bacillus megaterium strain FDU301 plasmid pFDU301I, complete sequence	0 crisprs	NA	0	0	0
NZ_CP045267	Bacillus megaterium strain FDU301 plasmid pFDU301E, complete sequence	0 crisprs	NA	0	0	0
NZ_CP045276	Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence	1 crisprs	NA	0	1	0
NZ_CP045273	Bacillus megaterium strain FDU301 plasmid pFDU301A, complete sequence	0 crisprs	cas8b1,cas7b,cas5,cas3,Cas14b_CAS-V-F,c2c9_V-U4,DEDDh,RT	0	0	0
NZ_CP045269	Bacillus megaterium strain FDU301 plasmid pFDU301G, complete sequence	0 crisprs	DEDDh	0	0	0
NZ_CP045270	Bacillus megaterium strain FDU301 plasmid pFDU301H, complete sequence	0 crisprs	NA	0	0	0
NZ_CP045274	Bacillus megaterium strain FDU301 plasmid pFDU301B, complete sequence	0 crisprs	csa3	0	0	0
NZ_CP045272	Bacillus megaterium strain FDU301 chromosome, complete genome	5 crisprs	cas3,DEDDh,WYL,csa3,DinG	0	1	3
NZ_CP045268	Bacillus megaterium strain FDU301 plasmid pFDU301F, complete sequence	0 crisprs	NA	0	0	0
NZ_CP045275	Bacillus megaterium strain FDU301 plasmid pFDU301C, complete sequence	1 crisprs	WYL,RT	1	1	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP045272_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045272_3

2271687-2271770

Orphan

Consensus_repeat	Method
TAGTACGCTAAAAACGGCAAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045272_3

>merge|NZ_CP045272|3|2271687-2271770|CRISPRCasFinder
CAGTACGTCAAAAATGGCAAAAGCTATTTTTAGTACGTGAAAAACGTCAAAAACGACGTAGTAGTACGACAAAAACAGCAAAAG

>NZ_CP045272|3|3|2271687-2271770|CRISPRCasFinder
CAGTACGTCAAAAATGGCAAAAG	CTATTTTTAGTACGTGAAAAACGTCAAAAACGACGTAG
TAGTACGACAAAAACAGCAAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045272.1\|WP_171777059.1\|2276412_2277915_+\|malate:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|377591
NZ_CP045272.1\|WP_047932376.1\|2267074_2268091_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226728
NZ_CP045272.1\|WP_171777058.1\|2263073_2264153_+\|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|227091
NZ_CP045272.1\|WP_171777827.1\|2264533_2264914_-\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730
NZ_CP045272.1\|WP_016764594.1\|2268800_2269397_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP045272.1\|WP_115648261.1\|2265117_2265411_+\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730
NZ_CP045272.1\|WP_034651039.1\|2281187_2281748_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP045272.1\|WP_171777057.1\|2260919_2262878_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224117
NZ_CP045272.1\|WP_013083666.1\|2274008_2274890_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|369792
NZ_CP045272.1\|WP_016764595.1\|2268219_2268798_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319825
NZ_CP045272.1\|WP_171777061.1\|2281946_2282777_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_CP045272.1\|WP_016764593.1\|2270239_2271262_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045272.1\|WP_016764587.1\|2280435_2280990_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP045272.1\|WP_013057538.1\|2278161_2278821_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|177683
NZ_CP045272.1\|WP_013057548.1\|2266582_2267002_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349995
NZ_CP045272.1\|WP_013083665.1\|2275467_2276292_+\|kinase/pyrophosphorylase	unknown	unknown	gnl\|CDD\|377080
NZ_CP045272.1\|WP_171777062.1\|2283089_2283503_+\|DUF4395-domain-containing-protein	unknown	unknown	gnl\|CDD\|379566
NZ_CP045272.1\|WP_016764597.1\|2265683_2266175_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045272.1\|WP_171777060.1\|2279241_2280066_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NZ_CP045272.1\|WP_013083667.1\|2272231_2273695_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP045272.1\|WP_013083666.1\|2274008_2274890_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	1.91536e-58
NZ_CP045272.1\|WP_171777058.1\|2263073_2264153_+\|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein	gnl\|CDD\|227091	COG4748, COG4748, Uncharacterized conserved protein [Function unknown].	3.81438e-123
NZ_CP045272.1\|WP_171777827.1\|2264533_2264914_-\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	2.41701e-16
NZ_CP045272.1\|WP_016764594.1\|2268800_2269397_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	1.31751e-24
NZ_CP045272.1\|WP_171777059.1\|2276412_2277915_+\|malate:quinone-oxidoreductase	gnl\|CDD\|377591	pfam06039, Mqo, Malate:quinone oxidoreductase (Mqo). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.	0
NZ_CP045272.1\|WP_171777057.1\|2260919_2262878_+\|hypothetical-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	1.55683e-05
NZ_CP045272.1\|WP_171777062.1\|2283089_2283503_+\|DUF4395-domain-containing-protein	gnl\|CDD\|379566	pfam14340, DUF4395, Domain of unknown function (DUF4395). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 142 and 168 amino acids in length. There are two completely conserved C residues that may be functionally important.	4.95027e-23
NZ_CP045272.1\|WP_016764595.1\|2268219_2268798_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319825	cd07523, HAD_YsbA-like, uncharacterized family of the haloacid dehalogenase-like superfamily, similar to the uncharacterized Lactococcus lactis YsbA. The specific function of Lactococcus lactis YsbA is unknown. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.96469e-43
NZ_CP045272.1\|WP_171777061.1\|2281946_2282777_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	3.66236e-72
NZ_CP045272.1\|WP_034651039.1\|2281187_2281748_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.0082524
NZ_CP045272.1\|WP_115648261.1\|2265117_2265411_+\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	3.13602e-20
NZ_CP045272.1\|WP_013057538.1\|2278161_2278821_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|177683	PLN00052, PLN00052, prolyl 4-hydroxylase; Provisional.	1.55318e-40
NZ_CP045272.1\|WP_013057548.1\|2266582_2267002_+\|hypothetical-protein	gnl\|CDD\|349995	cd18551, ABC_6TM_LmrA_like, Six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA and similar proteins. This group represents the six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA from Lactococcus lactis and similar proteins. This transmembrane (TM) subunit possesses the ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. Moreover, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis.	0.00168085
NZ_CP045272.1\|WP_013083665.1\|2275467_2276292_+\|kinase/pyrophosphorylase	gnl\|CDD\|377080	pfam03618, Kinase-PPPase, Kinase/pyrophosphorylase. This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity.	5.97841e-145
NZ_CP045272.1\|WP_016764587.1\|2280435_2280990_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.70491e-12
NZ_CP045272.1\|WP_047932376.1\|2267074_2268091_+\|hypothetical-protein	gnl\|CDD\|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	9.59365e-08
NZ_CP045272.1\|WP_171777060.1\|2279241_2280066_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	1.84799e-38

>NZ_CP045272.1|WP_016764593.1|2270239_2271262_-|hypothetical-protein
MIKKEFAKIGKQIIRQLSSTVEKYKDIEDHMDLDAHGNPTIKTVAEHHRLSKSQISQLIFYHFLHVDERGIICDVSEKEIAAALNCTVRTVRNNNVVLAETELISYSRSGKGINICIVPYPQYFEEHGFGFMELEYTRFEELILIENVNALRLELRKELVYDNDTIKRQFNPAENTSKISFNDYKIFTPKYTHYKGMMQKIAETQTSAFKTVVQGSTIFFVLKDGAKNGKMSKQEKKDQYAAAIRRTIEETFVKLSGHSTDSTGIVMSSFQNEDIADLVQLSFEYGIERVKSALYSLIEQAFFSHDAQVVENYGGKIRTLIRKELSKNLQDQVPAELTAS
>NZ_CP045272.1|WP_016764594.1|2268800_2269397_-|mechanosensitive-ion-channel
MKDIQWVQKTLFNTGKWIDISEVIIKIILIFIIAQIVIRFARSVINKIFDFRFKTKLLRYNERKEITLKKLCLSIVMYVVYFIVLITSLEAIGINMKALLAGISVAGFITGLGAQNLIKDILNGFFILFEDQFSVGDHVSINDTKGTVEEIGLRTTKIRGVDGEFYFFANSNITKVANYTLGEIPEVHKPEQIKTREE
>NZ_CP045272.1|WP_016764595.1|2268219_2268798_+|HAD-IA-family-hydrolase
MNILWDFDGTIFDTYPTIVKAFKELLTDQTISEDDILKQMKISSDIAIKHFDIEKSLFDKHFHVLEQKINPKDKPAFPHVEDVLSFADTNVIVTHKSRQSTLDILAFFNMEHYFTEIITKDDGYKRKPDSGAYAYLHDKYQLDLVIGDRELDLKPARELGIKTCAFQNDDIEADYHLTSYDQFFTTVVNKNS
>NZ_CP045272.1|WP_047932376.1|2267074_2268091_+|hypothetical-protein
MITAIIVGAVILLALIIKGIGKPRGFRLYKEELPDELGIHEGNGFEDIVHSLEDSLPKAYVQQVKQRMQGRNTKDDEVEWTFFEMKRYFLLNAVIKDVPMFSAKVDEVWHEMIMFTVDYGRFTDRFFDRFLHHQPNVDTTPSPQPDKRAFFDWMYAHLFDITGNSRLLWGKFFQHPLDKSTLQDFQRLSEDELLDRYFLRNGKWEKLQRALIQTLKEEINAARKRKKAGGSTYFKKTAKKGNVSNELLLQGFVFYSLYKATNFSSHMNELLLYKKTMYAGDTASYSGYSCSSPWEDNRHHHQHDGGHHHHDSGSSCSSSNCSSSSCSSSSCGSGCSSS
>NZ_CP045272.1|WP_013057548.1|2266582_2267002_+|hypothetical-protein
MSLSAKKILLLVLVVICLVLVVMQFINRSAEPTSEQAQETLSKLPEQETVKEKAKGDEEAHKYRVYYITIEKIENGTYSGTTKEGTGIKFSDKNLNEPIPSNLKKGDIVKAYFDLEYSTKGLVKVEKVDEMPDDDESSS
>NZ_CP045272.1|WP_016764597.1|2265683_2266175_-|hypothetical-protein
MMFALIVVVGIVALGVASFYVIKRPQGAVDPEDRKPLVSVNGHVKFAEGINQISISKIDMYDQRLVINQVAIIPFNRIQRAEFSKVVKNEKGLHGAPVQRYFGELTIHFTDKNGQETYISCETPKKNQFHLIYQYDLMKRQLNKRLGLEDLQPYLTLQEPYEL
>NZ_CP045272.1|WP_115648261.1|2265117_2265411_+|DUF4183-domain-containing-protein
MLPQQEFRYIFPKKVRIFEYYTVAGGSKRIFTDQDALKEYGTQHILDPESYSYSNLFINGVLQPSSNYSVQKGLLIINTEDIPLEKSPVILQMIKVI
>NZ_CP045272.1|WP_171777827.1|2264533_2264914_-|DUF4183-domain-containing-protein
MPLQIMKLAIAATTTVTASPTVSRFFYAATTTTTGAATLTIDAADFFGDTGGAATALPALATDNSYYNVYINGVLQMAGLSTYTPGATGVGSLAITVPAGSSVLTGSPIVLEVVNFAPDSDTDVQT
>NZ_CP045272.1|WP_171777058.1|2263073_2264153_+|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein
MDNFIQQIKTLSNRIERIKDNIKTEEATKTSLIMPFIQALGYDVFNPEEFVPEFIADVGIKKGEKIDYAIMDSGNPVILIEAKSVHEELLKHDSQLFRYFGTTKAKFAILTNGIEYRFYTDLEEPNKMDVKPFFIFNLLEFRDNDIHEVSKFRKNVFNVDHVLTTASELKYTSEIKLFLNQQWEEPNDEFIKFILSDVYQGVKTKKVIDNFREIVQKALAQFVNEKVSDKLQKALDSSATNEEHTVEKDETPKNESAAEDKITIETIVTTEEEIEGYVFVKLLLKDKIDSSRVHYRDNKSYFNVLLDNSIRKWVCRLGFNTANKYIQLNDEEKTIYKLNDVNEISLYKDEILEVAKQFQ
>NZ_CP045272.1|WP_171777057.1|2260919_2262878_+|hypothetical-protein
MGRLKIEKIMYEGDNYYFESPKFEEGINIIEGENGSGKSTFSNLINFSLGNYVKEFDKKEIKVHKEIVNDTNNYVVSIIYIDEDRYKLKRFFNDNRIFVEENGEIQDYLIHRPQNDVKIFSDWLLDKLGISVVEFYQGTAKSKLNFADLFRLIYYDQKTVPEKIYKDSRNDRNFISDSEFMRKVIFQMLMGHEFSEYYKLVGELNKKKKEKNDYKIKEEGFLKIASEFGFEDLNNVGLEDLEAKVKQKNLQLQRLEKYEAELLSVTQKPVDSTEKVRQLKKRLIDVELLFESTLNKINRLYKEIKSIENIKENTILEVTQIKKIILTHEELNLFSPNTCPYCLNNVERTEGHCICGKEIEESEYEKFFYSSDEYLAILKSKQKSIDTLNLAIESCNDELNYLETELKKLTKQKNDVQKLIEEVKEDVQRNTNVAEIKDIEQQRYALKGEISSLDQNYKVKQNFNEIEKGLTSTENKIKKINATLKTKNKEAKEEIETKITVFNEIYNNLLVDIKEDINQARINEENYMPIINGGEYKEASVDVPIRLMYFLTLLKMSVLDSKIPFPRFLLIDTPESLGIDKDNLEKSISKLLNDSDIDNDSDGDKVERSDFQIILTTGIKKYPEEFSSYKKGRSLNKNNKLLIKKEKNKQPN
>NZ_CP045272.1|WP_013083667.1|2272231_2273695_-|hypothetical-protein
MNEPSNFSPYLIKQISDAIDDNIKAKCIDFLYDSHSFFSNEKDFIEDYILNILQDTFVLENKLINPKEIRNPAYKRRQSNKKNWLQTLKKDIKAEKPNPIFEDIELAKKVMDKKVDTEHLKKLFGVEKPEDILKIKLKEVEAWAKSKKTNITDFPYLDSKMNYQIEKAFHTDFTFLIAEIILEKYNGNLSNWIDKRLNSWVEAPIFSNESHSLKTNMEVKTNSQEVVLYNDYKVDEEYFIRTIIPVNDNQTVLSKRNMVLDPKDSQIIQFALSQRDEMFYKEKTVTLDLADIVKEIYNSKGVKNYEAVEARIMKIARYHVEGVAKKKNSRDTKFAINFFQKAVIETDEVTGRRYATIVFSDDTHQGFLNQQFVQIYSDVIKKFKDNSLSSLLLYAFQKERLDCYLQEKSYTHFYPYQYFASKVRFRSKKIDVNLKLINESLAEFVSNQVLIQSYQQKLQGFEISFIPLQNYEIQDYFGGEHRETLEG
>NZ_CP045272.1|WP_013083666.1|2274008_2274890_+|Cof-type-HAD-IIB-family-hydrolase
MLLKPKAIFLDMDGTILNRSNKVSIQTKEIIDELRKQGIFVFIATGRAFDEIEELVPEGFQVDGFITSNGMAGYVGKESVFQHSLSLQLVETIIEKARANKVYYELFPYGTPRVTLKQDQSYVENEIREPKPDSVEINEWLSRKQAIKEEIDWKDSVEGSEFSKFYFFARTHEHIDKWKEELEELKKEIDFTTSTSSKHNVEVMVANVNKATGIQQMLKHFNLPEQDILAIGDSNNDLPMFQFASYAVAMKNAPDHIKEIVDDVTEFNCDENGVSHYLSKFLLQKSTRSNPVL
>NZ_CP045272.1|WP_013083665.1|2275467_2276292_+|kinase/pyrophosphorylase
MNKRKIVYIVSDSVGETAELMVKAVLTQFSGEDIEIQNTSYVEDEGNIDNIIAEARCNEAIIAYTIVIPPLKQYLDQKAQEEGIVAIDLMTPLMSAFSQTFNKEPNLQPRLTRKLDDNYFRRVEAVEFAVKYDDGQDFRGIKRADLVLIGVSRTSKTPLSMYLAHKSLKVANIPLVPEVTPPDELFTIPKNKCIGLVITPDKLNEIRKERLKNLGLASQANYANVDRILEELDYAEKIMKRIGCPIVNVSGKAVEETAEVILSMLKKDKMKGYV
>NZ_CP045272.1|WP_171777059.1|2276412_2277915_+|malate:quinone-oxidoreductase
MSNVYKKTDVILIGAGVMSATLGSLLKELAPEWEIKVFEKLADAGEESSNEWNNAGTGHAALCELNYTSEQADGSIDITKAVRINEQFQLSRQFWSYLVSSNLIHHPQKFIMPIPHMSFVQGEKNVSFLKKRFEALSNNPLFQGMEYSDRPEKLKEWMPLVMKGRTSTEAIAATKIDSGTDVNFGALTRMLFTHLKSKRVEINYNHSVENLTRTADGSWEVKVHDIHTGKQEYHTANFVFIGGGGGSLSLLQKTGIPESKHIGGFPVSGLFMVCNNPEVVAQHHGKVYGKAKVGAPPMSVPHLDTRYIDRKKTLLFGPFAGFSPKFLKTGSNLDLINSVKPNNILTMLAAGVKEMGLTKYLIQQVLLSDEKRMEELREFIPNAKSEDWDIVVAGQRVQVIKDTEAGGKGTLQFGTEVVSSADGSVAALLGASPGASTAVHVMLEVLEKCFPQHMKKWESKIKEMIPSYGLSLVENPALFNEIHASTSQTLDLSKKELVYR
>NZ_CP045272.1|WP_013057538.1|2278161_2278821_+|2OG-Fe(II)-oxygenase
MILTNTSLLTKEQTIFNHTGNKIKLEDREIDIVARFEEPLVLVLGNVLSNEECDELIQLSKDKMQRSKIGAAREVNSIRTSSGMFFEESENELVHQIERRLSKIMGPSIEYAEGLQVLKYLPDQEYKAHHDYFTSASKASKNNRISTLVMYLNDVEEGGETYFPKLGLSVSPTKGMAVYFEYFYSDAELNDRTLHGGAPVIKGEKWVATQWMRKQKIRS
>NZ_CP045272.1|WP_171777060.1|2279241_2280066_+|thermonuclease-family-protein
MKEIKAIICTMLAMFMLLLTGCSDEQASHSSTSSADTKQAVQVEDSSDQEEDHSPSKANREDVVGEAATVERVVDGDTLKVKMLNGKRDRVRLLLVDTPETKHPNLGVQPFGPEASAYTKKRLEGQEITLEFDVQERDQYGRLLAYVWIDNELYNEELLAKGLARVAVFPPNTKYVDEFKKIQEQARKSEKGIWSIENYAQEKGYNTDAVKNQSPSKQKDTQSAKSCEGKIKGNQNSKIYHVPTGAHYNQTMNHVIWFCTEKDAQEAGYKKAKN
>NZ_CP045272.1|WP_016764587.1|2280435_2280990_+|GNAT-family-N-acetyltransferase
MKIRKARKEDASAVTELLYDMLGSIARSHTAATTNEEALLRLKAFILSEKNRYSYHHITIAEVEEKVVGLMLCYEGSMLQTLYEPVKRFVRAKLNNPAWEIDIETEHGDYYIDSLCVDEAYRGKGIGTALLNVAKQEAKKRKMFLSLNVEYNNVEAKKLYQRIGFQEHKTIFIDKKPFFYMKTA
>NZ_CP045272.1|WP_034651039.1|2281187_2281748_+|hypothetical-protein
MNIRDLPFNMSYRFNEQLREVPVNPHQMKQGIIYLKKRALEEEDECAAAKTYGHIGVYERILGELTSSERHLLLAIYLYDRHADTIGEFLNTIRLGHTYHWQEQWDKANETFQLLIEQLKADEDLHIYEDFVYQHYGKCLLDQRVVSRAHHYFQRALEIRLKKGDKELIESTNSCIRLCLNKLKHS
>NZ_CP045272.1|WP_171777061.1|2281946_2282777_+|YitT-family-protein
MSKTVKDVIFLLIGSFVFSLAVNMFVIPIGLGEGGVTGISIILYYTTHLSTGSTNFILNGILLIVGYKFLEKKTIVYTIITIIATSIFLHVTEGWGLHLHEELIGMVFAGVLLGVGIGMILRVGGTTAGSAIIARILNKFLNWKVSHALLIVDLLVVLASYFIIGIEKLLFTIVMLYITTKVIDFVIEGFDAKKAVTVISSNKNEVADQINEQLDRGVTILNGRGNYTKESKEILYVVINKQELIKLKKLIKKIDDEAFVIVHDVRDVIGKGFLSA
>NZ_CP045272.1|WP_171777062.1|2283089_2283503_+|DUF4395-domain-containing-protein
MSIPKPLVQLNQLFIVITVLIALLAAKWFLLLPFLIGVVTLATKRNPVIMAGKKLLKKPASSYQMEDRDQQLFNQWIATICMGVAFISFLMGYTLVGYVFSIMVILAAGVALMGYCIGCTIRYRYMMWKYKRKKHAA

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Crispr_ID: NZ_CP045272_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045272_2

2271530-2271614

Orphan

Consensus_repeat	Method
TAGTACGCTAAAAACGGCAAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045272_2

>merge|NZ_CP045272|2|2271530-2271614|CRISPRCasFinder
TAGTACGTAAAAAACGGCAAAAGGCTCAGTATAGTACGCCAAAAATAGCAAAAGTGAAGAGTAGTACGCTAAAAACAGCAAAAGT

>NZ_CP045272|2|2|2271530-2271614|CRISPRCasFinder
TAGTACGTAAAAAACGGCAAAAG	GCTCAGTATAGTACGCCAAAAATAGCAAAAGTGAAGAG
TAGTACGCTAAAAACAGCAAAAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045272.1\|WP_171777059.1\|2276412_2277915_+\|malate:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|377591
NZ_CP045272.1\|WP_047932376.1\|2267074_2268091_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226728
NZ_CP045272.1\|WP_171777058.1\|2263073_2264153_+\|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|227091
NZ_CP045272.1\|WP_171777827.1\|2264533_2264914_-\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730
NZ_CP045272.1\|WP_016764594.1\|2268800_2269397_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP045272.1\|WP_115648261.1\|2265117_2265411_+\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730
NZ_CP045272.1\|WP_034651039.1\|2281187_2281748_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP045272.1\|WP_171777057.1\|2260919_2262878_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224117
NZ_CP045272.1\|WP_013083666.1\|2274008_2274890_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|369792
NZ_CP045272.1\|WP_016764595.1\|2268219_2268798_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319825
NZ_CP045272.1\|WP_171777061.1\|2281946_2282777_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_CP045272.1\|WP_016764593.1\|2270239_2271262_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045272.1\|WP_016764587.1\|2280435_2280990_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP045272.1\|WP_013057538.1\|2278161_2278821_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|177683
NZ_CP045272.1\|WP_013057548.1\|2266582_2267002_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349995
NZ_CP045272.1\|WP_013083665.1\|2275467_2276292_+\|kinase/pyrophosphorylase	unknown	unknown	gnl\|CDD\|377080
NZ_CP045272.1\|WP_171777062.1\|2283089_2283503_+\|DUF4395-domain-containing-protein	unknown	unknown	gnl\|CDD\|379566
NZ_CP045272.1\|WP_016764597.1\|2265683_2266175_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045272.1\|WP_171777060.1\|2279241_2280066_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NZ_CP045272.1\|WP_013083667.1\|2272231_2273695_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP045272.1\|WP_013083666.1\|2274008_2274890_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	1.91536e-58
NZ_CP045272.1\|WP_171777058.1\|2263073_2264153_+\|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein	gnl\|CDD\|227091	COG4748, COG4748, Uncharacterized conserved protein [Function unknown].	3.81438e-123
NZ_CP045272.1\|WP_171777827.1\|2264533_2264914_-\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	2.41701e-16
NZ_CP045272.1\|WP_016764594.1\|2268800_2269397_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	1.31751e-24
NZ_CP045272.1\|WP_171777059.1\|2276412_2277915_+\|malate:quinone-oxidoreductase	gnl\|CDD\|377591	pfam06039, Mqo, Malate:quinone oxidoreductase (Mqo). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.	0
NZ_CP045272.1\|WP_171777057.1\|2260919_2262878_+\|hypothetical-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	1.55683e-05
NZ_CP045272.1\|WP_171777062.1\|2283089_2283503_+\|DUF4395-domain-containing-protein	gnl\|CDD\|379566	pfam14340, DUF4395, Domain of unknown function (DUF4395). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 142 and 168 amino acids in length. There are two completely conserved C residues that may be functionally important.	4.95027e-23
NZ_CP045272.1\|WP_016764595.1\|2268219_2268798_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319825	cd07523, HAD_YsbA-like, uncharacterized family of the haloacid dehalogenase-like superfamily, similar to the uncharacterized Lactococcus lactis YsbA. The specific function of Lactococcus lactis YsbA is unknown. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.96469e-43
NZ_CP045272.1\|WP_171777061.1\|2281946_2282777_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	3.66236e-72
NZ_CP045272.1\|WP_034651039.1\|2281187_2281748_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.0082524
NZ_CP045272.1\|WP_115648261.1\|2265117_2265411_+\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	3.13602e-20
NZ_CP045272.1\|WP_013057538.1\|2278161_2278821_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|177683	PLN00052, PLN00052, prolyl 4-hydroxylase; Provisional.	1.55318e-40
NZ_CP045272.1\|WP_013057548.1\|2266582_2267002_+\|hypothetical-protein	gnl\|CDD\|349995	cd18551, ABC_6TM_LmrA_like, Six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA and similar proteins. This group represents the six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA from Lactococcus lactis and similar proteins. This transmembrane (TM) subunit possesses the ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. Moreover, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis.	0.00168085
NZ_CP045272.1\|WP_013083665.1\|2275467_2276292_+\|kinase/pyrophosphorylase	gnl\|CDD\|377080	pfam03618, Kinase-PPPase, Kinase/pyrophosphorylase. This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity.	5.97841e-145
NZ_CP045272.1\|WP_016764587.1\|2280435_2280990_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.70491e-12
NZ_CP045272.1\|WP_047932376.1\|2267074_2268091_+\|hypothetical-protein	gnl\|CDD\|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	9.59365e-08
NZ_CP045272.1\|WP_171777060.1\|2279241_2280066_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	1.84799e-38

>NZ_CP045272.1|WP_016764593.1|2270239_2271262_-|hypothetical-protein
MIKKEFAKIGKQIIRQLSSTVEKYKDIEDHMDLDAHGNPTIKTVAEHHRLSKSQISQLIFYHFLHVDERGIICDVSEKEIAAALNCTVRTVRNNNVVLAETELISYSRSGKGINICIVPYPQYFEEHGFGFMELEYTRFEELILIENVNALRLELRKELVYDNDTIKRQFNPAENTSKISFNDYKIFTPKYTHYKGMMQKIAETQTSAFKTVVQGSTIFFVLKDGAKNGKMSKQEKKDQYAAAIRRTIEETFVKLSGHSTDSTGIVMSSFQNEDIADLVQLSFEYGIERVKSALYSLIEQAFFSHDAQVVENYGGKIRTLIRKELSKNLQDQVPAELTAS
>NZ_CP045272.1|WP_016764594.1|2268800_2269397_-|mechanosensitive-ion-channel
MKDIQWVQKTLFNTGKWIDISEVIIKIILIFIIAQIVIRFARSVINKIFDFRFKTKLLRYNERKEITLKKLCLSIVMYVVYFIVLITSLEAIGINMKALLAGISVAGFITGLGAQNLIKDILNGFFILFEDQFSVGDHVSINDTKGTVEEIGLRTTKIRGVDGEFYFFANSNITKVANYTLGEIPEVHKPEQIKTREE
>NZ_CP045272.1|WP_016764595.1|2268219_2268798_+|HAD-IA-family-hydrolase
MNILWDFDGTIFDTYPTIVKAFKELLTDQTISEDDILKQMKISSDIAIKHFDIEKSLFDKHFHVLEQKINPKDKPAFPHVEDVLSFADTNVIVTHKSRQSTLDILAFFNMEHYFTEIITKDDGYKRKPDSGAYAYLHDKYQLDLVIGDRELDLKPARELGIKTCAFQNDDIEADYHLTSYDQFFTTVVNKNS
>NZ_CP045272.1|WP_047932376.1|2267074_2268091_+|hypothetical-protein
MITAIIVGAVILLALIIKGIGKPRGFRLYKEELPDELGIHEGNGFEDIVHSLEDSLPKAYVQQVKQRMQGRNTKDDEVEWTFFEMKRYFLLNAVIKDVPMFSAKVDEVWHEMIMFTVDYGRFTDRFFDRFLHHQPNVDTTPSPQPDKRAFFDWMYAHLFDITGNSRLLWGKFFQHPLDKSTLQDFQRLSEDELLDRYFLRNGKWEKLQRALIQTLKEEINAARKRKKAGGSTYFKKTAKKGNVSNELLLQGFVFYSLYKATNFSSHMNELLLYKKTMYAGDTASYSGYSCSSPWEDNRHHHQHDGGHHHHDSGSSCSSSNCSSSSCSSSSCGSGCSSS
>NZ_CP045272.1|WP_013057548.1|2266582_2267002_+|hypothetical-protein
MSLSAKKILLLVLVVICLVLVVMQFINRSAEPTSEQAQETLSKLPEQETVKEKAKGDEEAHKYRVYYITIEKIENGTYSGTTKEGTGIKFSDKNLNEPIPSNLKKGDIVKAYFDLEYSTKGLVKVEKVDEMPDDDESSS
>NZ_CP045272.1|WP_016764597.1|2265683_2266175_-|hypothetical-protein
MMFALIVVVGIVALGVASFYVIKRPQGAVDPEDRKPLVSVNGHVKFAEGINQISISKIDMYDQRLVINQVAIIPFNRIQRAEFSKVVKNEKGLHGAPVQRYFGELTIHFTDKNGQETYISCETPKKNQFHLIYQYDLMKRQLNKRLGLEDLQPYLTLQEPYEL
>NZ_CP045272.1|WP_115648261.1|2265117_2265411_+|DUF4183-domain-containing-protein
MLPQQEFRYIFPKKVRIFEYYTVAGGSKRIFTDQDALKEYGTQHILDPESYSYSNLFINGVLQPSSNYSVQKGLLIINTEDIPLEKSPVILQMIKVI
>NZ_CP045272.1|WP_171777827.1|2264533_2264914_-|DUF4183-domain-containing-protein
MPLQIMKLAIAATTTVTASPTVSRFFYAATTTTTGAATLTIDAADFFGDTGGAATALPALATDNSYYNVYINGVLQMAGLSTYTPGATGVGSLAITVPAGSSVLTGSPIVLEVVNFAPDSDTDVQT
>NZ_CP045272.1|WP_171777058.1|2263073_2264153_+|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein
MDNFIQQIKTLSNRIERIKDNIKTEEATKTSLIMPFIQALGYDVFNPEEFVPEFIADVGIKKGEKIDYAIMDSGNPVILIEAKSVHEELLKHDSQLFRYFGTTKAKFAILTNGIEYRFYTDLEEPNKMDVKPFFIFNLLEFRDNDIHEVSKFRKNVFNVDHVLTTASELKYTSEIKLFLNQQWEEPNDEFIKFILSDVYQGVKTKKVIDNFREIVQKALAQFVNEKVSDKLQKALDSSATNEEHTVEKDETPKNESAAEDKITIETIVTTEEEIEGYVFVKLLLKDKIDSSRVHYRDNKSYFNVLLDNSIRKWVCRLGFNTANKYIQLNDEEKTIYKLNDVNEISLYKDEILEVAKQFQ
>NZ_CP045272.1|WP_171777057.1|2260919_2262878_+|hypothetical-protein
MGRLKIEKIMYEGDNYYFESPKFEEGINIIEGENGSGKSTFSNLINFSLGNYVKEFDKKEIKVHKEIVNDTNNYVVSIIYIDEDRYKLKRFFNDNRIFVEENGEIQDYLIHRPQNDVKIFSDWLLDKLGISVVEFYQGTAKSKLNFADLFRLIYYDQKTVPEKIYKDSRNDRNFISDSEFMRKVIFQMLMGHEFSEYYKLVGELNKKKKEKNDYKIKEEGFLKIASEFGFEDLNNVGLEDLEAKVKQKNLQLQRLEKYEAELLSVTQKPVDSTEKVRQLKKRLIDVELLFESTLNKINRLYKEIKSIENIKENTILEVTQIKKIILTHEELNLFSPNTCPYCLNNVERTEGHCICGKEIEESEYEKFFYSSDEYLAILKSKQKSIDTLNLAIESCNDELNYLETELKKLTKQKNDVQKLIEEVKEDVQRNTNVAEIKDIEQQRYALKGEISSLDQNYKVKQNFNEIEKGLTSTENKIKKINATLKTKNKEAKEEIETKITVFNEIYNNLLVDIKEDINQARINEENYMPIINGGEYKEASVDVPIRLMYFLTLLKMSVLDSKIPFPRFLLIDTPESLGIDKDNLEKSISKLLNDSDIDNDSDGDKVERSDFQIILTTGIKKYPEEFSSYKKGRSLNKNNKLLIKKEKNKQPN
>NZ_CP045272.1|WP_013083667.1|2272231_2273695_-|hypothetical-protein
MNEPSNFSPYLIKQISDAIDDNIKAKCIDFLYDSHSFFSNEKDFIEDYILNILQDTFVLENKLINPKEIRNPAYKRRQSNKKNWLQTLKKDIKAEKPNPIFEDIELAKKVMDKKVDTEHLKKLFGVEKPEDILKIKLKEVEAWAKSKKTNITDFPYLDSKMNYQIEKAFHTDFTFLIAEIILEKYNGNLSNWIDKRLNSWVEAPIFSNESHSLKTNMEVKTNSQEVVLYNDYKVDEEYFIRTIIPVNDNQTVLSKRNMVLDPKDSQIIQFALSQRDEMFYKEKTVTLDLADIVKEIYNSKGVKNYEAVEARIMKIARYHVEGVAKKKNSRDTKFAINFFQKAVIETDEVTGRRYATIVFSDDTHQGFLNQQFVQIYSDVIKKFKDNSLSSLLLYAFQKERLDCYLQEKSYTHFYPYQYFASKVRFRSKKIDVNLKLINESLAEFVSNQVLIQSYQQKLQGFEISFIPLQNYEIQDYFGGEHRETLEG
>NZ_CP045272.1|WP_013083666.1|2274008_2274890_+|Cof-type-HAD-IIB-family-hydrolase
MLLKPKAIFLDMDGTILNRSNKVSIQTKEIIDELRKQGIFVFIATGRAFDEIEELVPEGFQVDGFITSNGMAGYVGKESVFQHSLSLQLVETIIEKARANKVYYELFPYGTPRVTLKQDQSYVENEIREPKPDSVEINEWLSRKQAIKEEIDWKDSVEGSEFSKFYFFARTHEHIDKWKEELEELKKEIDFTTSTSSKHNVEVMVANVNKATGIQQMLKHFNLPEQDILAIGDSNNDLPMFQFASYAVAMKNAPDHIKEIVDDVTEFNCDENGVSHYLSKFLLQKSTRSNPVL
>NZ_CP045272.1|WP_013083665.1|2275467_2276292_+|kinase/pyrophosphorylase
MNKRKIVYIVSDSVGETAELMVKAVLTQFSGEDIEIQNTSYVEDEGNIDNIIAEARCNEAIIAYTIVIPPLKQYLDQKAQEEGIVAIDLMTPLMSAFSQTFNKEPNLQPRLTRKLDDNYFRRVEAVEFAVKYDDGQDFRGIKRADLVLIGVSRTSKTPLSMYLAHKSLKVANIPLVPEVTPPDELFTIPKNKCIGLVITPDKLNEIRKERLKNLGLASQANYANVDRILEELDYAEKIMKRIGCPIVNVSGKAVEETAEVILSMLKKDKMKGYV
>NZ_CP045272.1|WP_171777059.1|2276412_2277915_+|malate:quinone-oxidoreductase
MSNVYKKTDVILIGAGVMSATLGSLLKELAPEWEIKVFEKLADAGEESSNEWNNAGTGHAALCELNYTSEQADGSIDITKAVRINEQFQLSRQFWSYLVSSNLIHHPQKFIMPIPHMSFVQGEKNVSFLKKRFEALSNNPLFQGMEYSDRPEKLKEWMPLVMKGRTSTEAIAATKIDSGTDVNFGALTRMLFTHLKSKRVEINYNHSVENLTRTADGSWEVKVHDIHTGKQEYHTANFVFIGGGGGSLSLLQKTGIPESKHIGGFPVSGLFMVCNNPEVVAQHHGKVYGKAKVGAPPMSVPHLDTRYIDRKKTLLFGPFAGFSPKFLKTGSNLDLINSVKPNNILTMLAAGVKEMGLTKYLIQQVLLSDEKRMEELREFIPNAKSEDWDIVVAGQRVQVIKDTEAGGKGTLQFGTEVVSSADGSVAALLGASPGASTAVHVMLEVLEKCFPQHMKKWESKIKEMIPSYGLSLVENPALFNEIHASTSQTLDLSKKELVYR
>NZ_CP045272.1|WP_013057538.1|2278161_2278821_+|2OG-Fe(II)-oxygenase
MILTNTSLLTKEQTIFNHTGNKIKLEDREIDIVARFEEPLVLVLGNVLSNEECDELIQLSKDKMQRSKIGAAREVNSIRTSSGMFFEESENELVHQIERRLSKIMGPSIEYAEGLQVLKYLPDQEYKAHHDYFTSASKASKNNRISTLVMYLNDVEEGGETYFPKLGLSVSPTKGMAVYFEYFYSDAELNDRTLHGGAPVIKGEKWVATQWMRKQKIRS
>NZ_CP045272.1|WP_171777060.1|2279241_2280066_+|thermonuclease-family-protein
MKEIKAIICTMLAMFMLLLTGCSDEQASHSSTSSADTKQAVQVEDSSDQEEDHSPSKANREDVVGEAATVERVVDGDTLKVKMLNGKRDRVRLLLVDTPETKHPNLGVQPFGPEASAYTKKRLEGQEITLEFDVQERDQYGRLLAYVWIDNELYNEELLAKGLARVAVFPPNTKYVDEFKKIQEQARKSEKGIWSIENYAQEKGYNTDAVKNQSPSKQKDTQSAKSCEGKIKGNQNSKIYHVPTGAHYNQTMNHVIWFCTEKDAQEAGYKKAKN
>NZ_CP045272.1|WP_016764587.1|2280435_2280990_+|GNAT-family-N-acetyltransferase
MKIRKARKEDASAVTELLYDMLGSIARSHTAATTNEEALLRLKAFILSEKNRYSYHHITIAEVEEKVVGLMLCYEGSMLQTLYEPVKRFVRAKLNNPAWEIDIETEHGDYYIDSLCVDEAYRGKGIGTALLNVAKQEAKKRKMFLSLNVEYNNVEAKKLYQRIGFQEHKTIFIDKKPFFYMKTA
>NZ_CP045272.1|WP_034651039.1|2281187_2281748_+|hypothetical-protein
MNIRDLPFNMSYRFNEQLREVPVNPHQMKQGIIYLKKRALEEEDECAAAKTYGHIGVYERILGELTSSERHLLLAIYLYDRHADTIGEFLNTIRLGHTYHWQEQWDKANETFQLLIEQLKADEDLHIYEDFVYQHYGKCLLDQRVVSRAHHYFQRALEIRLKKGDKELIESTNSCIRLCLNKLKHS
>NZ_CP045272.1|WP_171777061.1|2281946_2282777_+|YitT-family-protein
MSKTVKDVIFLLIGSFVFSLAVNMFVIPIGLGEGGVTGISIILYYTTHLSTGSTNFILNGILLIVGYKFLEKKTIVYTIITIIATSIFLHVTEGWGLHLHEELIGMVFAGVLLGVGIGMILRVGGTTAGSAIIARILNKFLNWKVSHALLIVDLLVVLASYFIIGIEKLLFTIVMLYITTKVIDFVIEGFDAKKAVTVISSNKNEVADQINEQLDRGVTILNGRGNYTKESKEILYVVINKQELIKLKKLIKKIDDEAFVIVHDVRDVIGKGFLSA
>NZ_CP045272.1|WP_171777062.1|2283089_2283503_+|DUF4395-domain-containing-protein
MSIPKPLVQLNQLFIVITVLIALLAAKWFLLLPFLIGVVTLATKRNPVIMAGKKLLKKPASSYQMEDRDQQLFNQWIATICMGVAFISFLMGYTLVGYVFSIMVILAAGVALMGYCIGCTIRYRYMMWKYKRKKHAA

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Crispr_ID: NZ_CP045272_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045272_1

2271372-2271464

Orphan

Consensus_repeat	Method
TAGTACGCTAAAAACGGCAAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045272_1

>merge|NZ_CP045272|1|2271372-2271464|CRISPRCasFinder
TAGTACGCTAAAAACGGCAAAAGGTTCAAAGAATGCTGTCATATCAAGGGGTGCAGCGTATAGGTTTTTTAGTACGCCAAAAACGGCAAAAGC

>NZ_CP045272|1|1|2271372-2271464|CRISPRCasFinder
TAGTACGCTAAAAACGGCAAAAG	GTTCAAAGAATGCTGTCATATCAAGGGGTGCAGCGTATAGGTTTTT
TAGTACGCCAAAAACGGCAAAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045272.1\|WP_171777059.1\|2276412_2277915_+\|malate:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|377591
NZ_CP045272.1\|WP_047932376.1\|2267074_2268091_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226728
NZ_CP045272.1\|WP_171777058.1\|2263073_2264153_+\|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|227091
NZ_CP045272.1\|WP_171777827.1\|2264533_2264914_-\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730
NZ_CP045272.1\|WP_016764594.1\|2268800_2269397_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP045272.1\|WP_115648261.1\|2265117_2265411_+\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730
NZ_CP045272.1\|WP_034651039.1\|2281187_2281748_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP045272.1\|WP_171777057.1\|2260919_2262878_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224117
NZ_CP045272.1\|WP_013083666.1\|2274008_2274890_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|369792
NZ_CP045272.1\|WP_016764595.1\|2268219_2268798_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319825
NZ_CP045272.1\|WP_171777061.1\|2281946_2282777_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_CP045272.1\|WP_016764593.1\|2270239_2271262_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045272.1\|WP_016764587.1\|2280435_2280990_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP045272.1\|WP_013057538.1\|2278161_2278821_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|177683
NZ_CP045272.1\|WP_013057548.1\|2266582_2267002_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349995
NZ_CP045272.1\|WP_013083665.1\|2275467_2276292_+\|kinase/pyrophosphorylase	unknown	unknown	gnl\|CDD\|377080
NZ_CP045272.1\|WP_171777062.1\|2283089_2283503_+\|DUF4395-domain-containing-protein	unknown	unknown	gnl\|CDD\|379566
NZ_CP045272.1\|WP_016764597.1\|2265683_2266175_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045272.1\|WP_171777060.1\|2279241_2280066_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NZ_CP045272.1\|WP_013083667.1\|2272231_2273695_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP045272.1\|WP_013083666.1\|2274008_2274890_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	1.91536e-58
NZ_CP045272.1\|WP_171777058.1\|2263073_2264153_+\|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein	gnl\|CDD\|227091	COG4748, COG4748, Uncharacterized conserved protein [Function unknown].	3.81438e-123
NZ_CP045272.1\|WP_171777827.1\|2264533_2264914_-\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	2.41701e-16
NZ_CP045272.1\|WP_016764594.1\|2268800_2269397_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	1.31751e-24
NZ_CP045272.1\|WP_171777059.1\|2276412_2277915_+\|malate:quinone-oxidoreductase	gnl\|CDD\|377591	pfam06039, Mqo, Malate:quinone oxidoreductase (Mqo). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.	0
NZ_CP045272.1\|WP_171777057.1\|2260919_2262878_+\|hypothetical-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	1.55683e-05
NZ_CP045272.1\|WP_171777062.1\|2283089_2283503_+\|DUF4395-domain-containing-protein	gnl\|CDD\|379566	pfam14340, DUF4395, Domain of unknown function (DUF4395). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 142 and 168 amino acids in length. There are two completely conserved C residues that may be functionally important.	4.95027e-23
NZ_CP045272.1\|WP_016764595.1\|2268219_2268798_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319825	cd07523, HAD_YsbA-like, uncharacterized family of the haloacid dehalogenase-like superfamily, similar to the uncharacterized Lactococcus lactis YsbA. The specific function of Lactococcus lactis YsbA is unknown. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.96469e-43
NZ_CP045272.1\|WP_171777061.1\|2281946_2282777_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	3.66236e-72
NZ_CP045272.1\|WP_034651039.1\|2281187_2281748_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.0082524
NZ_CP045272.1\|WP_115648261.1\|2265117_2265411_+\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	3.13602e-20
NZ_CP045272.1\|WP_013057538.1\|2278161_2278821_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|177683	PLN00052, PLN00052, prolyl 4-hydroxylase; Provisional.	1.55318e-40
NZ_CP045272.1\|WP_013057548.1\|2266582_2267002_+\|hypothetical-protein	gnl\|CDD\|349995	cd18551, ABC_6TM_LmrA_like, Six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA and similar proteins. This group represents the six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA from Lactococcus lactis and similar proteins. This transmembrane (TM) subunit possesses the ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. Moreover, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis.	0.00168085
NZ_CP045272.1\|WP_013083665.1\|2275467_2276292_+\|kinase/pyrophosphorylase	gnl\|CDD\|377080	pfam03618, Kinase-PPPase, Kinase/pyrophosphorylase. This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity.	5.97841e-145
NZ_CP045272.1\|WP_016764587.1\|2280435_2280990_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.70491e-12
NZ_CP045272.1\|WP_047932376.1\|2267074_2268091_+\|hypothetical-protein	gnl\|CDD\|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	9.59365e-08
NZ_CP045272.1\|WP_171777060.1\|2279241_2280066_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	1.84799e-38

>NZ_CP045272.1|WP_016764593.1|2270239_2271262_-|hypothetical-protein
MIKKEFAKIGKQIIRQLSSTVEKYKDIEDHMDLDAHGNPTIKTVAEHHRLSKSQISQLIFYHFLHVDERGIICDVSEKEIAAALNCTVRTVRNNNVVLAETELISYSRSGKGINICIVPYPQYFEEHGFGFMELEYTRFEELILIENVNALRLELRKELVYDNDTIKRQFNPAENTSKISFNDYKIFTPKYTHYKGMMQKIAETQTSAFKTVVQGSTIFFVLKDGAKNGKMSKQEKKDQYAAAIRRTIEETFVKLSGHSTDSTGIVMSSFQNEDIADLVQLSFEYGIERVKSALYSLIEQAFFSHDAQVVENYGGKIRTLIRKELSKNLQDQVPAELTAS
>NZ_CP045272.1|WP_016764594.1|2268800_2269397_-|mechanosensitive-ion-channel
MKDIQWVQKTLFNTGKWIDISEVIIKIILIFIIAQIVIRFARSVINKIFDFRFKTKLLRYNERKEITLKKLCLSIVMYVVYFIVLITSLEAIGINMKALLAGISVAGFITGLGAQNLIKDILNGFFILFEDQFSVGDHVSINDTKGTVEEIGLRTTKIRGVDGEFYFFANSNITKVANYTLGEIPEVHKPEQIKTREE
>NZ_CP045272.1|WP_016764595.1|2268219_2268798_+|HAD-IA-family-hydrolase
MNILWDFDGTIFDTYPTIVKAFKELLTDQTISEDDILKQMKISSDIAIKHFDIEKSLFDKHFHVLEQKINPKDKPAFPHVEDVLSFADTNVIVTHKSRQSTLDILAFFNMEHYFTEIITKDDGYKRKPDSGAYAYLHDKYQLDLVIGDRELDLKPARELGIKTCAFQNDDIEADYHLTSYDQFFTTVVNKNS
>NZ_CP045272.1|WP_047932376.1|2267074_2268091_+|hypothetical-protein
MITAIIVGAVILLALIIKGIGKPRGFRLYKEELPDELGIHEGNGFEDIVHSLEDSLPKAYVQQVKQRMQGRNTKDDEVEWTFFEMKRYFLLNAVIKDVPMFSAKVDEVWHEMIMFTVDYGRFTDRFFDRFLHHQPNVDTTPSPQPDKRAFFDWMYAHLFDITGNSRLLWGKFFQHPLDKSTLQDFQRLSEDELLDRYFLRNGKWEKLQRALIQTLKEEINAARKRKKAGGSTYFKKTAKKGNVSNELLLQGFVFYSLYKATNFSSHMNELLLYKKTMYAGDTASYSGYSCSSPWEDNRHHHQHDGGHHHHDSGSSCSSSNCSSSSCSSSSCGSGCSSS
>NZ_CP045272.1|WP_013057548.1|2266582_2267002_+|hypothetical-protein
MSLSAKKILLLVLVVICLVLVVMQFINRSAEPTSEQAQETLSKLPEQETVKEKAKGDEEAHKYRVYYITIEKIENGTYSGTTKEGTGIKFSDKNLNEPIPSNLKKGDIVKAYFDLEYSTKGLVKVEKVDEMPDDDESSS
>NZ_CP045272.1|WP_016764597.1|2265683_2266175_-|hypothetical-protein
MMFALIVVVGIVALGVASFYVIKRPQGAVDPEDRKPLVSVNGHVKFAEGINQISISKIDMYDQRLVINQVAIIPFNRIQRAEFSKVVKNEKGLHGAPVQRYFGELTIHFTDKNGQETYISCETPKKNQFHLIYQYDLMKRQLNKRLGLEDLQPYLTLQEPYEL
>NZ_CP045272.1|WP_115648261.1|2265117_2265411_+|DUF4183-domain-containing-protein
MLPQQEFRYIFPKKVRIFEYYTVAGGSKRIFTDQDALKEYGTQHILDPESYSYSNLFINGVLQPSSNYSVQKGLLIINTEDIPLEKSPVILQMIKVI
>NZ_CP045272.1|WP_171777827.1|2264533_2264914_-|DUF4183-domain-containing-protein
MPLQIMKLAIAATTTVTASPTVSRFFYAATTTTTGAATLTIDAADFFGDTGGAATALPALATDNSYYNVYINGVLQMAGLSTYTPGATGVGSLAITVPAGSSVLTGSPIVLEVVNFAPDSDTDVQT
>NZ_CP045272.1|WP_171777058.1|2263073_2264153_+|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein
MDNFIQQIKTLSNRIERIKDNIKTEEATKTSLIMPFIQALGYDVFNPEEFVPEFIADVGIKKGEKIDYAIMDSGNPVILIEAKSVHEELLKHDSQLFRYFGTTKAKFAILTNGIEYRFYTDLEEPNKMDVKPFFIFNLLEFRDNDIHEVSKFRKNVFNVDHVLTTASELKYTSEIKLFLNQQWEEPNDEFIKFILSDVYQGVKTKKVIDNFREIVQKALAQFVNEKVSDKLQKALDSSATNEEHTVEKDETPKNESAAEDKITIETIVTTEEEIEGYVFVKLLLKDKIDSSRVHYRDNKSYFNVLLDNSIRKWVCRLGFNTANKYIQLNDEEKTIYKLNDVNEISLYKDEILEVAKQFQ
>NZ_CP045272.1|WP_171777057.1|2260919_2262878_+|hypothetical-protein
MGRLKIEKIMYEGDNYYFESPKFEEGINIIEGENGSGKSTFSNLINFSLGNYVKEFDKKEIKVHKEIVNDTNNYVVSIIYIDEDRYKLKRFFNDNRIFVEENGEIQDYLIHRPQNDVKIFSDWLLDKLGISVVEFYQGTAKSKLNFADLFRLIYYDQKTVPEKIYKDSRNDRNFISDSEFMRKVIFQMLMGHEFSEYYKLVGELNKKKKEKNDYKIKEEGFLKIASEFGFEDLNNVGLEDLEAKVKQKNLQLQRLEKYEAELLSVTQKPVDSTEKVRQLKKRLIDVELLFESTLNKINRLYKEIKSIENIKENTILEVTQIKKIILTHEELNLFSPNTCPYCLNNVERTEGHCICGKEIEESEYEKFFYSSDEYLAILKSKQKSIDTLNLAIESCNDELNYLETELKKLTKQKNDVQKLIEEVKEDVQRNTNVAEIKDIEQQRYALKGEISSLDQNYKVKQNFNEIEKGLTSTENKIKKINATLKTKNKEAKEEIETKITVFNEIYNNLLVDIKEDINQARINEENYMPIINGGEYKEASVDVPIRLMYFLTLLKMSVLDSKIPFPRFLLIDTPESLGIDKDNLEKSISKLLNDSDIDNDSDGDKVERSDFQIILTTGIKKYPEEFSSYKKGRSLNKNNKLLIKKEKNKQPN
>NZ_CP045272.1|WP_013083667.1|2272231_2273695_-|hypothetical-protein
MNEPSNFSPYLIKQISDAIDDNIKAKCIDFLYDSHSFFSNEKDFIEDYILNILQDTFVLENKLINPKEIRNPAYKRRQSNKKNWLQTLKKDIKAEKPNPIFEDIELAKKVMDKKVDTEHLKKLFGVEKPEDILKIKLKEVEAWAKSKKTNITDFPYLDSKMNYQIEKAFHTDFTFLIAEIILEKYNGNLSNWIDKRLNSWVEAPIFSNESHSLKTNMEVKTNSQEVVLYNDYKVDEEYFIRTIIPVNDNQTVLSKRNMVLDPKDSQIIQFALSQRDEMFYKEKTVTLDLADIVKEIYNSKGVKNYEAVEARIMKIARYHVEGVAKKKNSRDTKFAINFFQKAVIETDEVTGRRYATIVFSDDTHQGFLNQQFVQIYSDVIKKFKDNSLSSLLLYAFQKERLDCYLQEKSYTHFYPYQYFASKVRFRSKKIDVNLKLINESLAEFVSNQVLIQSYQQKLQGFEISFIPLQNYEIQDYFGGEHRETLEG
>NZ_CP045272.1|WP_013083666.1|2274008_2274890_+|Cof-type-HAD-IIB-family-hydrolase
MLLKPKAIFLDMDGTILNRSNKVSIQTKEIIDELRKQGIFVFIATGRAFDEIEELVPEGFQVDGFITSNGMAGYVGKESVFQHSLSLQLVETIIEKARANKVYYELFPYGTPRVTLKQDQSYVENEIREPKPDSVEINEWLSRKQAIKEEIDWKDSVEGSEFSKFYFFARTHEHIDKWKEELEELKKEIDFTTSTSSKHNVEVMVANVNKATGIQQMLKHFNLPEQDILAIGDSNNDLPMFQFASYAVAMKNAPDHIKEIVDDVTEFNCDENGVSHYLSKFLLQKSTRSNPVL
>NZ_CP045272.1|WP_013083665.1|2275467_2276292_+|kinase/pyrophosphorylase
MNKRKIVYIVSDSVGETAELMVKAVLTQFSGEDIEIQNTSYVEDEGNIDNIIAEARCNEAIIAYTIVIPPLKQYLDQKAQEEGIVAIDLMTPLMSAFSQTFNKEPNLQPRLTRKLDDNYFRRVEAVEFAVKYDDGQDFRGIKRADLVLIGVSRTSKTPLSMYLAHKSLKVANIPLVPEVTPPDELFTIPKNKCIGLVITPDKLNEIRKERLKNLGLASQANYANVDRILEELDYAEKIMKRIGCPIVNVSGKAVEETAEVILSMLKKDKMKGYV
>NZ_CP045272.1|WP_171777059.1|2276412_2277915_+|malate:quinone-oxidoreductase
MSNVYKKTDVILIGAGVMSATLGSLLKELAPEWEIKVFEKLADAGEESSNEWNNAGTGHAALCELNYTSEQADGSIDITKAVRINEQFQLSRQFWSYLVSSNLIHHPQKFIMPIPHMSFVQGEKNVSFLKKRFEALSNNPLFQGMEYSDRPEKLKEWMPLVMKGRTSTEAIAATKIDSGTDVNFGALTRMLFTHLKSKRVEINYNHSVENLTRTADGSWEVKVHDIHTGKQEYHTANFVFIGGGGGSLSLLQKTGIPESKHIGGFPVSGLFMVCNNPEVVAQHHGKVYGKAKVGAPPMSVPHLDTRYIDRKKTLLFGPFAGFSPKFLKTGSNLDLINSVKPNNILTMLAAGVKEMGLTKYLIQQVLLSDEKRMEELREFIPNAKSEDWDIVVAGQRVQVIKDTEAGGKGTLQFGTEVVSSADGSVAALLGASPGASTAVHVMLEVLEKCFPQHMKKWESKIKEMIPSYGLSLVENPALFNEIHASTSQTLDLSKKELVYR
>NZ_CP045272.1|WP_013057538.1|2278161_2278821_+|2OG-Fe(II)-oxygenase
MILTNTSLLTKEQTIFNHTGNKIKLEDREIDIVARFEEPLVLVLGNVLSNEECDELIQLSKDKMQRSKIGAAREVNSIRTSSGMFFEESENELVHQIERRLSKIMGPSIEYAEGLQVLKYLPDQEYKAHHDYFTSASKASKNNRISTLVMYLNDVEEGGETYFPKLGLSVSPTKGMAVYFEYFYSDAELNDRTLHGGAPVIKGEKWVATQWMRKQKIRS
>NZ_CP045272.1|WP_171777060.1|2279241_2280066_+|thermonuclease-family-protein
MKEIKAIICTMLAMFMLLLTGCSDEQASHSSTSSADTKQAVQVEDSSDQEEDHSPSKANREDVVGEAATVERVVDGDTLKVKMLNGKRDRVRLLLVDTPETKHPNLGVQPFGPEASAYTKKRLEGQEITLEFDVQERDQYGRLLAYVWIDNELYNEELLAKGLARVAVFPPNTKYVDEFKKIQEQARKSEKGIWSIENYAQEKGYNTDAVKNQSPSKQKDTQSAKSCEGKIKGNQNSKIYHVPTGAHYNQTMNHVIWFCTEKDAQEAGYKKAKN
>NZ_CP045272.1|WP_016764587.1|2280435_2280990_+|GNAT-family-N-acetyltransferase
MKIRKARKEDASAVTELLYDMLGSIARSHTAATTNEEALLRLKAFILSEKNRYSYHHITIAEVEEKVVGLMLCYEGSMLQTLYEPVKRFVRAKLNNPAWEIDIETEHGDYYIDSLCVDEAYRGKGIGTALLNVAKQEAKKRKMFLSLNVEYNNVEAKKLYQRIGFQEHKTIFIDKKPFFYMKTA
>NZ_CP045272.1|WP_034651039.1|2281187_2281748_+|hypothetical-protein
MNIRDLPFNMSYRFNEQLREVPVNPHQMKQGIIYLKKRALEEEDECAAAKTYGHIGVYERILGELTSSERHLLLAIYLYDRHADTIGEFLNTIRLGHTYHWQEQWDKANETFQLLIEQLKADEDLHIYEDFVYQHYGKCLLDQRVVSRAHHYFQRALEIRLKKGDKELIESTNSCIRLCLNKLKHS
>NZ_CP045272.1|WP_171777061.1|2281946_2282777_+|YitT-family-protein
MSKTVKDVIFLLIGSFVFSLAVNMFVIPIGLGEGGVTGISIILYYTTHLSTGSTNFILNGILLIVGYKFLEKKTIVYTIITIIATSIFLHVTEGWGLHLHEELIGMVFAGVLLGVGIGMILRVGGTTAGSAIIARILNKFLNWKVSHALLIVDLLVVLASYFIIGIEKLLFTIVMLYITTKVIDFVIEGFDAKKAVTVISSNKNEVADQINEQLDRGVTILNGRGNYTKESKEILYVVINKQELIKLKKLIKKIDDEAFVIVHDVRDVIGKGFLSA
>NZ_CP045272.1|WP_171777062.1|2283089_2283503_+|DUF4395-domain-containing-protein
MSIPKPLVQLNQLFIVITVLIALLAAKWFLLLPFLIGVVTLATKRNPVIMAGKKLLKKPASSYQMEDRDQQLFNQWIATICMGVAFISFLMGYTLVGYVFSIMVILAAGVALMGYCIGCTIRYRYMMWKYKRKKHAA

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Crispr_ID: NZ_CP045272_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045272_4

4878042-4878140

Orphan

Consensus_repeat	Method
TGCTTGAGCATTTTGTTGTTTCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045272_4

>merge|NZ_CP045272|4|4878042-4878140|CRISPRCasFinder
AGCTTGTGCGTTTTGTTGTCTCACTTCTTGAGCACTTGTTTCGCTAGCAAATTCAGTACCGAAGTTGTTTTTAGATGCTTGAGCATTTTGGCTTTTGTT

>NZ_CP045272|4|4|4878042-4878140|CRISPRCasFinder
AGCTTGTGCGTTTTGTTGTCTCAC	TTCTTGAGCACTTGTTTCGCTAGCAAATTCAGTACCGAAGTTGTTTTTAGA
TGCTTGAGCATTTTGGCTTTTGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045272.1\|WP_013055167.1\|4870709_4871723_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213234
NZ_CP045272.1\|WP_013081554.1\|4868644_4869037_-\|two-pore-domain-potassium-channel-family-protein	unknown	unknown	unknown
NZ_CP045272.1\|WP_047931907.1\|4879256_4879481_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045272.1\|WP_013055171.1\|4868104_4868575_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NZ_CP045272.1\|WP_016762869.1\|4874896_4876648_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP045272.1\|WP_034654804.1\|4882531_4882846_-\|YfhH-family-protein	unknown	unknown	gnl\|CDD\|378063
NZ_CP045272.1\|WP_013081552.1\|4869925_4870717_-\|ABC-2-family-transporter-protein	unknown	unknown	gnl\|CDD\|226953
NZ_CP045272.1\|WP_014461824.1\|4877549_4877810_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372951
NZ_CP045272.1\|WP_016762865.1\|4882297_4882453_+\|small,-acid-soluble-spore-protein-K	unknown	unknown	gnl\|CDD\|285399
NZ_CP045272.1\|WP_013055163.1\|4876817_4877354_-\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|184219
NZ_CP045272.1\|WP_013055156.1\|4881892_4882162_-\|YfhJ-family-protein	unknown	unknown	gnl\|CDD\|379438
NZ_CP045272.1\|WP_171777872.1\|4880848_4881829_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|224899
NZ_CP045272.1\|WP_028410116.1\|4871925_4873224_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|183493
NZ_CP045272.1\|WP_016762864.1\|4882928_4883582_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187643
NZ_CP045272.1\|WP_171777744.1\|4884778_4885681_+\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|187553
NZ_CP045272.1\|WP_170836848.1\|4878390_4879143_-\|enoyl-[acyl-carrier-protein]-reductase-FabL	unknown	unknown	gnl\|CDD\|236145
NZ_CP045272.1\|WP_034655325.1\|4869130_4869916_-\|ABC-2-family-transporter-protein	unknown	unknown	gnl\|CDD\|226218
NZ_CP045272.1\|WP_013081550.1\|4873772_4874861_+\|aromatic-acid-exporter-family-protein	unknown	unknown	gnl\|CDD\|226614
NZ_CP045272.1\|WP_013081541.1\|4883871_4884681_-\|recombination-regulator-RecX	unknown	unknown	gnl\|CDD\|237619
NZ_CP045272.1\|WP_047931906.1\|4879514_4880609_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115

Protein	Function_ID	Function_description	E-value
NZ_CP045272.1\|WP_013055167.1\|4870709_4871723_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213234	cd03267, ABC_NatA_like, ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA. NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.	1.65462e-121
NZ_CP045272.1\|WP_013055171.1\|4868104_4868575_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	5.31486e-80
NZ_CP045272.1\|WP_016762869.1\|4874896_4876648_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP045272.1\|WP_034654804.1\|4882531_4882846_-\|YfhH-family-protein	gnl\|CDD\|378063	pfam08838, DUF1811, Protein of unknown function (DUF1811). This is a bacterial family of uncharacterized proteins. Some of the proteins are annotated as being transcriptional regulators. The structure of one of the proteins in this family has revealed a beta-barrel like structure with helix-turn-helix like motif.	2.3812e-59
NZ_CP045272.1\|WP_013081552.1\|4869925_4870717_-\|ABC-2-family-transporter-protein	gnl\|CDD\|226953	COG4587, COG4587, ABC-type uncharacterized transport system, permease component [General function prediction only].	2.41995e-29
NZ_CP045272.1\|WP_014461824.1\|4877549_4877810_-\|hypothetical-protein	gnl\|CDD\|372951	pfam14182, YgaB, YgaB-like protein. The YgaB-like protein family includes the B. subtilis YgaB protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	8.73208e-20
NZ_CP045272.1\|WP_016762865.1\|4882297_4882453_+\|small,-acid-soluble-spore-protein-K	gnl\|CDD\|285399	pfam08176, SspK, Small acid-soluble spore protein K family. This family consists of the small acid-soluble spore proteins (SASP) belonging to the K type (sspK). The sspK are unique to the spores of Bacillus subtilis and are expressed only in the forespore compartment of sporulating cells of this organism. The sspK gene is monocistronic and transcription is primarily by the RNA polymerase with the forespore-specific sigma factor, sigma-G. Mutation deleting sspK results in loss of SspK from the spore but had no discernible effect on sporulation, spore properties or spore germination.	2.11098e-16
NZ_CP045272.1\|WP_013055163.1\|4876817_4877354_-\|DUF402-domain-containing-protein	gnl\|CDD\|184219	PRK13662, PRK13662, hypothetical protein; Provisional.	2.65481e-127
NZ_CP045272.1\|WP_013055156.1\|4881892_4882162_-\|YfhJ-family-protein	gnl\|CDD\|379438	pfam14043, WVELL, WVELL protein. This family includes the B. subtilis YfjH protein, which is functionally uncharacterized. This is not a homolog of E. coli YfjH, a synonym for IscX, which belongs to pfam04384. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length and contain a highly conserved WVELL motif.	7.28774e-43
NZ_CP045272.1\|WP_171777872.1\|4880848_4881829_+\|metal-dependent-hydrolase	gnl\|CDD\|224899	COG1988, COG1988, Predicted membrane-bound metal-dependent hydrolases [General function prediction only].	8.17733e-35
NZ_CP045272.1\|WP_028410116.1\|4871925_4873224_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|183493	PRK12389, PRK12389, glutamate-1-semialdehyde aminotransferase; Provisional.	0
NZ_CP045272.1\|WP_016762864.1\|4882928_4883582_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187643	cd08939, KDSR-like_SDR_c, 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR. These proteins include members identified as KDSR, ribitol type dehydrogenase, and others. The group shows strong conservation of the active site tetrad and glycine rich NAD-binding motif of the classical SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.21581e-56
NZ_CP045272.1\|WP_171777744.1\|4884778_4885681_+\|TIGR01777-family-protein	gnl\|CDD\|187553	cd05242, SDR_a8, atypical (a) SDRs, subgroup 8. This subgroup contains atypical SDRs of unknown function. Proteins in this subgroup have a glycine-rich NAD(P)-binding motif consensus that resembles that of the extended SDRs, (GXXGXXG or GGXGXXG), but lacks the characteristic active site residues of the SDRs. A Cys often replaces the usual Lys of the YXXXK active site motif, while the upstream Ser is generally present and Arg replaces the usual Asn. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.65071e-139
NZ_CP045272.1\|WP_170836848.1\|4878390_4879143_-\|enoyl-[acyl-carrier-protein]-reductase-FabL	gnl\|CDD\|236145	PRK08063, PRK08063, enoyl-[acyl-carrier-protein] reductase FabL.	8.81546e-173
NZ_CP045272.1\|WP_034655325.1\|4869130_4869916_-\|ABC-2-family-transporter-protein	gnl\|CDD\|226218	COG3694, COG3694, ABC-type uncharacterized transport system, permease component [General function prediction only].	2.51572e-45
NZ_CP045272.1\|WP_013081550.1\|4873772_4874861_+\|aromatic-acid-exporter-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	3.54796e-67
NZ_CP045272.1\|WP_013081541.1\|4883871_4884681_-\|recombination-regulator-RecX	gnl\|CDD\|237619	PRK14135, recX, recombination regulator RecX; Provisional.	8.10118e-120
NZ_CP045272.1\|WP_047931906.1\|4879514_4880609_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	2.34865e-150

>NZ_CP045272.1|WP_014461824.1|4877549_4877810_-|hypothetical-protein
MKKFDQLVTQQLETMDQLLFLQSEIERCQEIEGELVKLHEEAKLHSVQDEISEMKLKLKEIQLTFEAQTEDIIRTYKSEGACSTLA
>NZ_CP045272.1|WP_013055163.1|4876817_4877354_-|DUF402-domain-containing-protein
MGIPVEGETIQIHSYKHNGHIHRVWDRTTVLKATNNLVIGGNDRTVVTESDGRTWVTREPAICYFHAQQWFNVIGMIREDGIYYYCNISSPFIYDDNEALKYIDYDLDIKVYPDMTYTLLDEDEYEKHRKEMNYPEVIDRILHNHVEELKGWIRQRKGPFAPDFIDIWYERFLTYRHS
>NZ_CP045272.1|WP_016762869.1|4874896_4876648_-|ABC-transporter-ATP-binding-protein
MGSIRRYMKFVQPYKWQIVGTVLIGIIKFAIPLLIPLLLKYVLDDIVNGHGMSSSEKVHKMVTIMGISFVVFLVLRPPIEYYRQYYAQWVSSKVLYDIRDQLFSHIQKLSLRYYANTRAGEVISRVINDVEQTKNFVITGLMNVWLDMMTIVIAIVIMFTMNVPLTLVSIILLPVYAFSVKYFYSRLRHLTRVRSQALAEVQGHLHERVQGISVIRSFAIEPHEQKQFDKQNSNFLQKAINHTNWNAKTFAVVNTITDLAPLIVITFAGYQVITESLSVGTMVAFVAYIDRLYNPLRRLVNSSTTLTQSVASMDRVFEFIDEEYDITDKKDAKECTELHGKVQFEHVSFAYEEEEKPVIHDINLDVEKGKSVAFVGMSGGGKSTLISLIPRFYDVTEGKILIDDIDIKTYKVRSLRDKIGIVLQDTVLFSDTVKNNILLGKPGATDEEVIAAAKAANAHDFIMNLPEGYDTKVGERGMKLSGGQKQRISISRVFLKNPAILIFDEATSALDLESEHYIQEALAELAKDRTTFIVAHRLSTITHVDEIVLLENGRVVERGSHEELIKKKGHYYQLFNVQQLDTI
>NZ_CP045272.1|WP_013081550.1|4873772_4874861_+|aromatic-acid-exporter-family-protein
MKLGARILKTGIAITLSLLLGEFLSLPSPIFAAIAAVFAIQPSIYRSYLTILEQIQANVIGAASAVCFGLIFGTHPIIIGFTAVVVIAVNLKLRINNTIGLALVTVIAIMENPGDNFVEYALIRFGTVLLGVFSAFIVNLIFIPPKYETRLYYKIVSTTEEIIKWIRMNLYHASEHTLLKEDIEKMKDNVAKMNQIFDFYKEERTYSTKKRFVKSRKLVLFRQMITVTTRALTTLKLLHRVENDLQVMPQQFQDLIKSEVECLLMYHEQVLLKFIGKLRVQPTTTVPNEACVGKRALIDKFMQYKIYDNDEENKVIYHIFPLISVIIEYSEELEHLDKLIDTFQNYHKDANSFDINHQRQED
>NZ_CP045272.1|WP_028410116.1|4871925_4873224_+|glutamate-1-semialdehyde-2,1-aminomutase
MQFTKSEQLHAEALEHIVGGVNSPSRSYKAVGGGAPVAMEKASGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITKAAETGVLYGTPTAHEVTFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRDKIIKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPKSIANEVITVPFNDIEPYKEALEKWGDQIAAVLVEPIVGNFGIVEPEPGFLEQVNELTHEAGALVIYDEVITAFRFMYGGAQDLLGVKPDLTAFGKIIGGGLPIGAYGGKKEIMEKVAPLGPAYQAGTMAGNPASILSGIACLEVLKQEGVYEQLDKLGAMLEEGILKHARTYNMPITINRLKGALTVYFTTETVKNYEQAENTDGELFARFFKLMLHQGVNLAPSKYEAWFLTTAHTEQDITDTLEAVEKAFKQLSEER
>NZ_CP045272.1|WP_013055167.1|4870709_4871723_-|ATP-binding-cassette-domain-containing-protein
MKNAIEVNQLRKEFKAYSSRSGLKGAFRDLFTRNYRVMKAVNDISFTVKQGEMVGYIGENGAGKSTTIKMLTGILTPTSGDITVNGMNPHKEREKFAQTIGVVFGQRSQLWWDIAVQESFRLLKKVYKVSDEDYNAHMEHVIQTLDIGPLLDKPVRKLSLGQRMRCELAAALIHNPPLLFLDEPTIGLDVLVKLKIRQFLKEINEKYNTTILLTTHDLADIEALCERVVMLDEGSIIYDGSLQKLRSNWGDLKQVTFEFGTAPNKEQLKLLTQGMPVNWIEGDQKYLWTAQLQNKGDLMSQLIAKVVAKHEISDINIEEISTEEIIRNIYEEGVVNG
>NZ_CP045272.1|WP_013081552.1|4869925_4870717_-|ABC-2-family-transporter-protein
MDKYIEMIRIRFLMMLAYRTNYYSGILIYAINIGAYYFLWSAIYGGKENIQGLSITQMTTYVAVSWMARAFYFNNIDREMATEIKDGKVAVELIKPYSYLGMKTMQGLGEGIFRLLFFSVPGMIIVAFLFPVQFSANAATWLYFGLSLIFSFIINTQINLLTGITTFFLFNNDGLIRAKRVVIDLFSGLLLPISFYPFWAQHIMSYFPFQAISYIPSMIFTNGFKGQEVINALITQAVWSGLLFIPIACLWNIAKKKMVIQGG
>NZ_CP045272.1|WP_034655325.1|4869130_4869916_-|ABC-2-family-transporter-protein
MFYFSIFFQYIGQYMKTRLQYRTDMVVEIISDLLFQTVNLIFILVVFGHTQSLHGWSREEIIFIYGFFLVPFAIFSSFFNIWDFNERYIVKGEMDRILTRPIHSLFQVILERMELESLFGGVTGIAVMAYAASSLHLHFQWYDVFIFLLFILGGALVYAGIFIALASIGFWSDARTSIMPTIYNIGNYGRYPVDIYNNVIRYVLTWILPFAFVGVYPAAYFLGRSEWYGYAFLTPVMGIVFFVISIFLWNTGVKKYRGAGN
>NZ_CP045272.1|WP_013081554.1|4868644_4869037_-|two-pore-domain-potassium-channel-family-protein
MVIFLILVIIVFVIGSMKFLFEKELGEFHFFSIGHFFVLFYSYITVLLGFSLIYTVCEMGSIPVLSGGFEHEGHYFYTLFNSMYFSAATLFSVGYGDMYPVGIGKLFATFEAFIGYIMPAIFVMRTVTRT
>NZ_CP045272.1|WP_013055171.1|4868104_4868575_-|thioredoxin-dependent-thiol-peroxidase
MTAVVGEKAPDFVLMSTNGEQVSLASMKGKNVVLYFYPKDMTPGCTTEACDFRDQHENFEELDAVILGVSPDPIDKHHKFIDKHGLPFLLLADEDHSVAEEYGVWTLKKNFGKEYMGIERSTFIINKEGMLVKEYRKVRVKGHVEEALSFIKEKMA
>NZ_CP045272.1|WP_170836848.1|4878390_4879143_-|enoyl-[acyl-carrier-protein]-reductase-FabL
MMSQKVALVTGSSRGIGKEIALRLAKEGYDIVLNYARSKSAAQEVAEEIKALGREALVVKANVGKVEKIKEMFEQIDEAFGRLDVFVSNAASGVLRPIMELEETHWNWTMDINSKGYLFCAQEAAKRMEKVGGGKIVTISSLGSIRYLENYTTVGVSKAAVEALTRYLAVELAPKNIVVNAVSGGAVDTEALKHFPNRDELLDDARKHTPAGRMVEPKDMVDAVMFLVSDQANMICGQTLIIDGGRSLLM
>NZ_CP045272.1|WP_047931907.1|4879256_4879481_+|hypothetical-protein
MYVGRDMTTLSMISKSEWKDSELAFFHHSLQQMTPYLNAEGQSIHQQIIKEIEARGGLQRHEADYTHGTHVSYD
>NZ_CP045272.1|WP_047931906.1|4879514_4880609_-|A/G-specific-adenine-glycosylase
MKQSKDIVQNFDIRAFQDDLISWFEQEQRILPWRQDQDPYKVWVSEIMLQQTRVDTVIPYFNNFISKFPTIKDLAYANEDDVLKAWEGLGYYSRARNLQTAVREVHEQYGGEVPNTPAEISKLKGVGPYTTGAILSIAYGVPQPAVDGNVMRVLSRILSVWDDIAKPKTRKLFEDIVHEIISKDNPSYFNQGMMELGAIVCTPTSPSCLLCPVREHCRAFEEGVQNELPVKSKKKAPRALQLAAAVIRDEDGNYLIHKRPNKGLLANLWEFPNIEVDLSIAPDHQQLQAFIQNEYGADIKINAPFTTIQHVFSHIVWNVTVYEAELVSDISALKNLKVVSEKDLEQYAFPVSHQKILKEYLLVK
>NZ_CP045272.1|WP_171777872.1|4880848_4881829_+|metal-dependent-hydrolase
MDTGTHIAMGIALGGLATLDPTVSANTATLDAVMIGVMAGSLAPDLDTVLKLRNNAQYIRNHRGITHSIPAVILWPLLIVLILSLLLPGANLLHLWMWTFASVIIHVFVDIFNAYGTQALRPFTNKWIALGVINTFDYVIFSAHVLAILIWFIGAEPGPTFITLYVLLAFYYGLRFYMRHQIAKKLRKQFPDVIKLNISPTLRFTHWHLAVTTERYFHVGRAIGEEIFIYDTFDKVPIPESAVIEVAKKDENLSAFLSFSPIYRWELDEYNDHIEVRFIDLRYRSKDYYPFVAVVQLDYDLNIICSYTGWIFSEKKLRKKLDYLPH
>NZ_CP045272.1|WP_013055156.1|4881892_4882162_-|YfhJ-family-protein
MNDIFERLTNQLLNKNSSLSYAQARTWVELFWEDFESSYAKAGYDYKGKEATEKVVTMYINSYGDKLHEIAVKNPKYQHLLNNDDYLKH
>NZ_CP045272.1|WP_016762865.1|4882297_4882453_+|small,-acid-soluble-spore-protein-K
MRNKAKDFTNQHHTKLEGEPRAKAEYASKRANGTINTHPQERMHASNEREE
>NZ_CP045272.1|WP_034654804.1|4882531_4882846_-|YfhH-family-protein
MSEKRYSDMTTYELQQEIGSLQEKARKAEQLGMVNEYAVLERKVTMARSYLLDPEAFKAGEVYEIQGDPGSYFKIDYMNGVFAWGFRLGSPQNEEALPISMLKK
>NZ_CP045272.1|WP_016762864.1|4882928_4883582_+|SDR-family-NAD(P)-dependent-oxidoreductase
MKTVLITGGATGLGKELAKLYAKDYNVILAGRNQHKLKEAQHELGDNVYTMSVDITKYEEVGKSVEKLLMQHSVDILINNAGIGHFGPLTDYTKQAIDEVIDTNVKGTIFLTQALMPHLLTRPEPKVMNIISTAGLRGKANESVYVASKFGVRGFTESLKVEYQDTSLHVIAAYMGGMNTPFWDHNNHIKDKSRLRSASEIAEIIYKQQNDSEDILF
>NZ_CP045272.1|WP_013081541.1|4883871_4884681_-|recombination-regulator-RecX
MPVVTKITTQKNSGERYNVYLDYGKGEEFGFGVDENVLIKYDLKKGRELDEFELTEIQYADDEKKAYNLAITYLSYRMRSEKEVHDYLKKKEINSTIIQQVIQKLVSHRYLNDEEFAKAFVLTQMNTTSKGPSVIQRELKEKGISDSTITLSLCEYPEEQQIQTAVKLIEKLKGKYKKLSQVMMKQKMEQALAVKGYSFSIIQEAFQRTNTEKESDEAWEALQYQGMKAHRRFSKYEGWEYQQKMKQALYRKGFSIDQIQSFLDSIEEE
>NZ_CP045272.1|WP_171777744.1|4884778_4885681_+|TIGR01777-family-protein
MKIVIAGGTGFVGKALTKHFLTQEHYVYILTRNADKAARDPKLKYVEWMQESSQPEEHVEGADVFINLAGVSLNSGRWTDERKKAIVESRLSSTQEILRIMAALPEKPSLYVNASAVGYYGTSTTETFTEASPSIGTDFLAETVKKWENEALKAMELNIRTVLTRFGVILGKDGGALPSTALPYKLFAGGTVGSGEQWMSWVHLQDVVKIIDYCIHTKQIEGPVNVTAPNPVQMKEFGKTIGKVLNRPHWMPVPSFGLQLLMGEMSMIILKGQRVLPEKLIQQNYIFTYTVLEDALRDLL

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Crispr_ID: NZ_CP045272_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045272_5

4931127-4931212

Orphan

Consensus_repeat	Method
TCCGTTGGCGTCTCTCCACCTTGATT	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NZ_CP045272_5

>merge|NZ_CP045272|5|4931127-4931212|CRISPRCasFinder
TCCGTTGGCGTCTCTCCACCTTGATTCGGATCTGGCTGAGTTCCGTCACCTTCCCCAGGGTCCGTTGGCGTCTCTCCGCCTTGATT

>NZ_CP045272|5|5|4931127-4931212|CRISPRCasFinder
TCCGTTGGCGTCTCTCCACCTTGATT	CGGATCTGGCTGAGTTCCGTCACCTTCCCCAGGG
TCCGTTGGCGTCTCTCCGCCTTGATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045272.1\|WP_171777753.1\|4918733_4919666_-\|D-2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240625
NZ_CP045272.1\|WP_128821326.1\|4921678_4922575_-\|amidase	unknown	unknown	unknown
NZ_CP045272.1\|WP_013081504.1\|4928194_4928671_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045272.1\|WP_171777752.1\|4917549_4918635_-\|nitric-oxide-synthase-oxygenase	unknown	unknown	gnl\|CDD\|376957
NZ_CP045272.1\|WP_013055105.1\|4938518_4938812_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|274862
NZ_CP045272.1\|WP_171777758.1\|4936866_4938171_-\|type-VII-secretion-protein-EssB	unknown	unknown	gnl\|CDD\|188441
NZ_CP045272.1\|WP_016762833.1\|4924444_4924960_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|237597
NZ_CP045272.1\|WP_034654749.1\|4940916_4942122_-\|DEAD/DEAH-box-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|223587
NZ_CP045272.1\|WP_171777757.1\|4932375_4936854_-\|type-VII-secretion-protein-EssC	unknown	unknown	gnl\|CDD\|274860
NZ_CP045272.1\|WP_034654765.1\|4919927_4921484_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP045272.1\|WP_034654747.1\|4942487_4943798_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|236901
NZ_CP045272.1\|WP_016762830.1\|4928721_4929219_-\|type-VII-secretion-protein-EssA	unknown	unknown	gnl\|CDD\|375148
NZ_CP045272.1\|WP_171777754.1\|4922738_4924076_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|379358
NZ_CP045272.1\|WP_034654746.1\|4943875_4944628_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912
NZ_CP045272.1\|WP_013055104.1\|4939184_4939577_-\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NZ_CP045272.1\|WP_034654756.1\|4926751_4927906_-\|endonuclease	unknown	unknown	gnl\|CDD\|225231
NZ_CP045272.1\|WP_047931879.1\|4939638_4940238_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NZ_CP045272.1\|WP_013055106.1\|4938185_4938425_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227704
NZ_CP045272.1\|WP_171777755.1\|4925009_4926647_-\|family-14-glycosylhydrolase	unknown	unknown	gnl\|CDD\|366599
NZ_CP045272.1\|WP_013055102.1\|4940347_4940665_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP045272.1\|WP_171777753.1\|4918733_4919666_-\|D-2-hydroxyacid-dehydrogenase	gnl\|CDD\|240625	cd05300, 2-Hacid_dh_1, Putative D-isomer specific 2-hydroxyacid dehydrogenase. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomains but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric. Formate dehydrogenase (FDH) catalyzes the NAD+-dependent oxidation of formate ion to carbon dioxide with the concomitant reduction of NAD+ to NADH. FDHs of this family contain no metal ions or prosthetic groups. Catalysis occurs though direct transfer of the hydride ion to NAD+ without the stages of acid-base catalysis typically found in related dehydrogenases. FDHs are found in all methylotrophic microorganisms in energy production and in the stress responses of plants.	9.09703e-115
NZ_CP045272.1\|WP_171777758.1\|4936866_4938171_-\|type-VII-secretion-protein-EssB	gnl\|CDD\|188441	TIGR03926, T7_EssB, type VII secretion protein EssB. Members of this family are associated with type VII secretion of WXG100 family targets in the Firmicutes, but not in the Actinobacteria. This protein is designated YukC in Bacillus subtilis and EssB is Staphylococcus aureus. [Protein fate, Protein and peptide secretion and trafficking].	1.63968e-116
NZ_CP045272.1\|WP_171777752.1\|4917549_4918635_-\|nitric-oxide-synthase-oxygenase	gnl\|CDD\|376957	pfam02898, NO_synthase, Nitric oxide synthase, oxygenase domain.	0
NZ_CP045272.1\|WP_013055105.1\|4938518_4938812_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.56462e-22
NZ_CP045272.1\|WP_016762833.1\|4924444_4924960_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|237597	PRK14054, PRK14054, peptide-methionine (S)-S-oxide reductase.	6.94464e-92
NZ_CP045272.1\|WP_034654749.1\|4940916_4942122_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	6.82686e-113
NZ_CP045272.1\|WP_171777757.1\|4932375_4936854_-\|type-VII-secretion-protein-EssC	gnl\|CDD\|274860	TIGR03928, T7_EssCb_Firm, type VII secretion protein EssC, C-terminal domain. This model describes the C-terminal domain, or longer subunit, of the Firmicutes type VII secretion protein EssC. This protein (homologous to EccC in Actinobacteria) and the WXG100 target proteins are the only homologous parts of type VII secretion between Firmicutes and Actinobacteria. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP045272.1\|WP_034654765.1\|4919927_4921484_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NZ_CP045272.1\|WP_034654747.1\|4942487_4943798_-\|PAS-domain-S-box-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	1.87674e-58
NZ_CP045272.1\|WP_016762830.1\|4928721_4929219_-\|type-VII-secretion-protein-EssA	gnl\|CDD\|375148	pfam17355, DUF5383, Family of unknown function (DUF5383). This is a family of unknown function found in Bacillales. Members of this family are predicted to contain one trans-membrane region.	5.23536e-41
NZ_CP045272.1\|WP_171777754.1\|4922738_4924076_-\|transcriptional-regulator	gnl\|CDD\|379358	pfam13749, HATPase_c_4, Putative ATP-dependent DNA helicase recG C-terminal. This domain may well interact selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	1.82453e-08
NZ_CP045272.1\|WP_034654746.1\|4943875_4944628_-\|STAS-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	1.53444e-15
NZ_CP045272.1\|WP_013055104.1\|4939184_4939577_-\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	2.64916e-09
NZ_CP045272.1\|WP_034654756.1\|4926751_4927906_-\|endonuclease	gnl\|CDD\|225231	COG2356, EndA, Endonuclease I [DNA replication, recombination, and repair].	1.51228e-59
NZ_CP045272.1\|WP_047931879.1\|4939638_4940238_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	0.000384343
NZ_CP045272.1\|WP_013055106.1\|4938185_4938425_-\|hypothetical-protein	gnl\|CDD\|227704	COG5417, COG5417, Uncharacterized small protein [Function unknown].	2.88289e-28
NZ_CP045272.1\|WP_171777755.1\|4925009_4926647_-\|family-14-glycosylhydrolase	gnl\|CDD\|366599	pfam01373, Glyco_hydro_14, Glycosyl hydrolase family 14. This family are beta amylases.	0

>NZ_CP045272.1|WP_016762830.1|4928721_4929219_-|type-VII-secretion-protein-EssA
MMKPIVLNKKIGSIVLIFSLLYFPIAAAAEADDGNVEEIKPNVYKDDPINLDPESLLENKKEVGNIPEEIKDLTFEKEEDVEKESLKESLFANASAEDNTISAKAKEYNLFSSKNTSYKKDRTEQTASEKSSDLQWFYLLLIGVGVVVLFAVLIPRISPQPSVKK
>NZ_CP045272.1|WP_013081504.1|4928194_4928671_+|hypothetical-protein
MLSFDEKLAIISSFPELHRKDVSLGRVNFHYEESVYDKTVVVHHLHPNGNGFVYGGFLKGYETNDKGLVNIRDYTEEELRSIIEASIESLSTLPDTAREEAIVGNGNEQRWNGPDNATLLLVHEDDLWNVYSGLNLEAAFLSYEEAEDYLFEEGFRRL
>NZ_CP045272.1|WP_034654756.1|4926751_4927906_-|endonuclease
MKLYALCKKTWAISLLVFVLLVSLTPVSQAAAFLSVAQALENQNNSVQTVKGYVVGQPTGTSTVITNNYPNDYALALADSSNETNTDKMVYVQIPSNLRSTFGLQSHSELRGKSLTVTGTLTPYFSHPGIKSVTSISTETGGTDPAPDPTEPTVPVEDYYRTAAEKTGNSLKTELHNIIDHHTELSYSAVWEALKKTDEDPANANNVILLYTGRSQAKSTNGGGVDDWNREHVWAKSHGDFGTAMGPGTDLHHLRPTDVSVNSTRGNLDFDNGGTEHSEALGNYFDSDSWEPRDEVKGDVARMLFYMAVRYEGDVSDEPDLELNNTVNNGTAPYHGKLSVLLQWNAQDPVDDRERRRNDIIYSDYQHNRNPFIDHPEWVNEIWN
>NZ_CP045272.1|WP_171777755.1|4925009_4926647_-|family-14-glycosylhydrolase
MKQLCKKGLAFVLMFIFVNAFILSPINGAAAVDGKSMNPGYKTYLMAPLKKVTDYTTWEAFENDLRKAKQNGFYAVTVDFWWGDMEKNGDQQFDFSYAQRFAQAARNAGIKIVPIISTHQCGGNVGDDCNVPLPSWVWNLKSDDSLYFKSETGTTNKETLSPLATDVISKQYGELYTAFAQALAPYKDVIAKIYLSGGPAGEIRYPSYTAADGTGYPSRGKFQVYTNFAKSKFQSYALTKYGSLAGINQAWGTNLTSASQILPPSDGYQFLKDGYSTAYGKDFLAWYQGALEDHTKRIGQLAHQAFDSTFNVPIGAKVAGIHWQYNNPTIPHAAEKPAGYNDYNALLDAFKIAKLDITFTCLEMTDSGNYPEYSMPKTLVRQVAGIANAKGVVLNGENALTIGSEDQYKKAAEMAFNYNFAGFTLLRFYDVINNDTLMGQFKNTLGVTPLAQTVVVKNAPTALGETVYIVGDRAELGQWDTSIYPIKLTYNSSTADWRGTVHFPASQNVQFKAIVKRADGSLKAWQPSQQYWSVPSTTTTYTDNW
>NZ_CP045272.1|WP_016762833.1|4924444_4924960_+|peptide-methionine-(S)-S-oxide-reductase-MsrA
MEKATFAGGCFWCMVTPFEELEGIHGIVSGYMGGTVDNPTYEQVKSGTSGYYEVVQITFDPEVFPYKRLLDLYWPQIDPTDDGGQFQDRGSQYRTAIFYHNDSQKQAAEETKLEVAESGRFKKPIVTSILPASTFYEAEEYHQDFHKKNPKHYKEDRAKSGRDEFIETNWK
>NZ_CP045272.1|WP_171777754.1|4922738_4924076_-|transcriptional-regulator
MLQDNLILEHYGLNELNFDTIKSYRDRFAEVKQAHPWNALETKEFLYKVGAWGKVRDTHKEGVTLAGLLLFSEERIITEVLPQYFLEYRESKGNEEWTERFTSQDGTWSGNIFDFYFHIHEIVRNSEPQPSIASSLTEVLINMLIHADYNGEGGVILEKQPSHYVFSNPGLLLVPTDSVFSNTVSQLRNPNIVKLFSLLGLCERSGSGLKKVKQNWSLHHYKTPAIDQDVSMHRTVVTLSLSTQERQVSSSEKDTYHTSATDSGNNFKDVEKYQNTPENNVEIDSYNKNKYSYNKGLIEEFKSYNNDVNSFNKEDNYYNNESNLYNNDVNSYINNHNSYNNEQEEDSSNLVNVENIDTKLWDIAALAREKKRLSPNQMEHIILELCKEKPLMLKEFAYLLERTPDGVRNNYLTKLLRKGQLQLKYPNQPNHPKQAYLFNKKDIEK
>NZ_CP045272.1|WP_128821326.1|4921678_4922575_-|amidase
MKSKCVLIFLVVVWLFNMGKGIGCGSKVNAEINIPLSTWVWDTKKWMLNQEAILEKLQEKKVTNVYLQIDTHLSPSVYRHFIQQAQAQGISVYALDGAPYWIGPSGIEEQEAFFNWITAYQAQADEPQQFLGVHLDVEPYLYKSWENNRAKSILQYQYVISQAAVQSHELHLPLAVDIPFWFDEVPFKNSNGSGLLGRWIIQYADEVTIMAYRNHADKENGIAEITENERKWGRVLSTPIEIGVETMASDEGEYISFSAKGEEKMMQELDMLLTECQAENPPSSIAVHHFDSWLQMKP
>NZ_CP045272.1|WP_034654765.1|4919927_4921484_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSVLNVKNLSHGFGDRAIFNDVSFRLLKGEHVGLIGANGEGKSTFMNIITGKLEPDAGKVEWSKKVRVGYLDQHTALERGLSIRDVLKSAFQYLFDLEAQMNGLYEKMAEVSPEELEKLLEEVGTLQDLLTNNDFYVIDAKVEEIARGLGLEDIGLDRDVQDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLRRYLQEYENAFILISHDLPFLNSVINLIYHMENQELNRYVGDYDDFMKVYEMKKQQLEAAYKKQQQEMADLKDFVARNKARVSTRNMAMSRQKKLDKMEVIELAQERPKPEFNFKGARTSSKLIFETSDLVIGYEEPLSKPLNLKMERGQKIALVGANGIGKTTLLKSILGEIKPISGSVEKGDYQHIGYFEQEIKTANYNTCIEEVWNEFSHFTQYEIRAALAKCGLTTKHIESKVEVLSGGEKAKVRLCKLINNETNILVLDEPTNHLDVDAKDELKRALKEYKGSILIICHEPEFYQDVVTDVWNCESWTTKLF
>NZ_CP045272.1|WP_171777753.1|4918733_4919666_-|D-2-hydroxyacid-dehydrogenase
MNIHTILVAGRMHKELEEIIKQKQLPQTFRFMEEQDVTIEDLNWADALLSFGPTNCFEDHSFKWIHSLGAGVDRFLESGNWKKSVMLTRTVCSFGQRISEYCLSYMLAELQHHAQFQHQQKQKQWKVIEPKQLSTQTVIIYGTGEIGGRLAAVLKSFGVRVMGVSKSGNEKPSFDQVVSISKEKELLKEADWIISTMPLTHETKSYFDPKWMNVVESAYFINVGRGATVDENALVEAIEKKRIRKAYIDVFEHEPLTKESSWWDHSNIIITPHISAVTTPEEAVGCFVETLQQVEQGGLPSNLVNIERGY
>NZ_CP045272.1|WP_171777752.1|4917549_4918635_-|nitric-oxide-synthase-oxygenase
MKQEELFEQARVFIETCYAELEKSEADKNKRLKEIHQQIMSLGHYDHTFEELEHGARMAWRNSNKCIGRLFWQSLNVFDKREASTVEEVRDALFHHIEYATNDGKIRPTITVFKPKMKAKEPVRIWNHQLIRYAGYETECGMVGDPASIAFTEVCRNLGWEGERTHFDVLPLVLQVNEGSPRCFDIPKHLVKEVAITHPELPEFEDLQLKWYAVPMISDMKLEIGGIDYVAAPFNGWYMGTEIGARNLADTYRYNQLPKIASMMGLNMDYNATLWKDKALVELNVAVLSSFKREGVSIVDHHTAAQQFHLFEEREQKNGREVTGNWTWLIPPVSPATTHIFHKPYKNKVLSPNYFYQDAAY
>NZ_CP045272.1|WP_171777757.1|4932375_4936854_-|type-VII-secretion-protein-EssC
MNMLWVVSRQTYQQLPVDFKTFRQATVGNTQHQTFTFSYPFEKGQMTLSSEKNGRLLISYGEKRIAELSVSESFVWREQGHALTFVLTDTAVKEAVYYIDYGSEVSFSTSDETADVYQQKEKCVVEPKEGFYLSKINGKWKVFYNQEPLYLNGHRLEENTNLQPGDLILWSSMTIQLIEKDLLKIQSCYDYASKLPTTAQPISEMKKKYPVYRRTPRMIYDLPNDKVSLSFPSQDNDENNRSLWLTILPPLVMLLVMGTVSIIQPRGIFIIISVMMFTTTLIVSTVQYFKDKKQRKKRQERRRRIYTKYLENKREELQELVSVQRDVLSYHFPTFERMKYLTEQISDRIWERTVESSDFLQVRLGTGTVPGSYQISLNSGDMANREIDDLLEQSQHMEKVYREVKNAPVTAHLGLGSIGLVGKMKTVKNELHQLVGQLAFSHSYHDVRFVFIFDEEEYKEWEWMKWLPHFQLPHSFAKGFIYNEQTRDQLLSSIYEMLRERDLDEAKGEGVFLPHFVFIITNQQLIADHVILEYLEGYHPHLGFSAIFAAETKESLTEHVHTLVRYINESEGDILIQKQKAVNIPFQLDKHTLDYNERFARMLRTLDHQVGMTNSIPNSVSFLELFKAREIGELDIVQRWQSNESAKSLAVPIGLKGKEDIVELNLHEKAHGPHGLLAGTTGSGKSEFLQTYILSLAVNFHPHEVAFLLIDYKGGGMAQPFKNMPHLLGTITNIEGSKNFSTRALASIKSELKRRQRLFDRYEVNHINDYTDLYKQGMAEEPLPHLFLISDEFAELKSEEPEFIRELVSAARIGRSLGVHLILATQKPGGVIDDQIWSNARFKVALKVQDAADSKEILKNADAASITVTGRGYLQVGNNEVYELFQSAWSGAPYMEDTYGAEDEVAIVTDLGLIPLSDVSTQQTSSKQAEAEIDVVVQKIEKTQQELAIKKLNSPWLPPLKERLLRSEYTEKRDGVFPIGLIDEPEKQSQTVYNYQLMDDGNIGIFGSSGYGKSFTVMMLLLNLAERKSPEQLHYYIFDFGNGTLLPLRQLPHTADYFLMDQMRKIEKFMTIIKQEIARRKQLFQQREVSNIKMYNALSSEELPLIFITIDNFDLVKEEMQDLEMQFTQLVRDGQSLGIYMIFTATRVNSIRQSLMNNLKTKVVHYLMDHSEAYSILGRTPYALESIPGRAIIKTDQPYFAQLFLPAEGKDDFEIFDAVKLHIQRLKNQYADAIVPEPVPMLSSKLVLVEFMTDRRVIREKGVIPLGLDEEFVRPVHMNFTKNKHCIVMGQTQKGKTNVVKVILQTALEQGVKQIGLFDSVDRSLSSYAAEEQVVYMETKEQIIDWLDLTEERLQRREIKYLEAVQEGTVHSLSFAPIMLVVDGFVRFQQNLDSVLQDRITKLMKNYSHLGFNLIVAGNNNEFSKGFDALTTEVKQISQAVLLMKKTEQSLFTLPYDRKEADINPGFGYYIKSGKETRIQIPLCVSERKILT
>NZ_CP045272.1|WP_171777758.1|4936866_4938171_-|type-VII-secretion-protein-EssB
MSEKKPTYLEEQLEAVMTRHNNEYTFVFQKEKIRLNRSVEIEMLKDVNTAFQKEIMMSDDELKITIKPTSEFQPFTALRGKEEQQKWLFADQLIKQVKQHSFSRLHLLICPENIIFDKSLSPAFLHYGVKESLPPYESNGEQSFQELKATIAAAVDSSHTFEQYFKLYETLQLKEDAKKIMHISNEEELSQFVQHKLTQIEKHQKTLIQLPQKRWTIFKFSSVGILVLLIPALIYNFYSYFFAQPKQEAFVESNEYFLEKNYSKVVDTLEDYDIESMPKIVQYEIATSYLVNEKLGEEQKANALKTITLQSDPQYFAYWFYIGRGDNKKALEVSRLLEERSLIIYALMKYEGQLKTDNDLAADKKQEELDKVANELEEFKKENDQQEAEAAKQQEEKQAEEAQAAKQQEEEQKAAEAEKKKQEEQKKQQEDQSK
>NZ_CP045272.1|WP_013055106.1|4938185_4938425_-|hypothetical-protein
MYIEVTVDLKHYTGDRFDLRLSNYHSLKKVVEIVWQAKKITQSPKDGAWIRVSNKNLIFSGNETMINCGITTGDCIEIL
>NZ_CP045272.1|WP_013055105.1|4938518_4938812_-|WXG100-family-type-VII-secretion-target
MSGIIRVTPAELRDMAGRYTNESGQVQELVSRLDTMKNQLQDMWEGASSEAFAAQYEELKPSFVEMSNLLTKIAKQLDDSANVLEDTDNQIASQIRG
>NZ_CP045272.1|WP_013055104.1|4939184_4939577_-|SseB-family-protein
MKYTFNLLEKSLIEAMKDNKKIAQFYKTLMNSNLWLVVSSEHGASDILIAEHYVQTMKSAAYRYLPVFSSKYPIEQMLKDEKTVCVSFKDMLPVLNEEIAILLNPDTPLSKLFIPEEIRMLKEDQNYFKQ
>NZ_CP045272.1|WP_047931879.1|4939638_4940238_-|WXG100-family-type-VII-secretion-target
MEIKVNPEVLRTFAERIQHSHSQTADALQKLSWEATNLHFLSVADIDKVLDLQEELQHMIRKLDSLTENAHLLVKDTAEQMRKADGELEGSSGWTEFWSSVWSNRGTHSQDTWNDIKNLKEWNTYDNMHRTIEKPLGTLNVMWNSLSMSWEEKVVNGSTCSRTEFFTYGVIQMGLGILSQEMNPSNIMFSDSTEEVKRE
>NZ_CP045272.1|WP_013055102.1|4940347_4940665_-|hypothetical-protein
MDAIDDLFDDIERRRKSKEYSRDADQLESYLHEVQRIMEFLEEGIYLFQNSHQQYASDWSGRSKSSYEDIYNDITQSTFHLYDVRDELFQTLRLEISRLRELASA
>NZ_CP045272.1|WP_034654749.1|4940916_4942122_-|DEAD/DEAH-box-helicase
MSQFIETLQPFLQEAWKKAGFNEPTVIQTKAISEILANKDVIGESPTGTGKTLAYLLPVLHRIQPGPSHIQAVILASSHELVMQIHGEIQTWSQGSGISSAAFIGGANMKRQLEKLKKRPNIIVGTPGRLNELIKMKKLKMHEVKTIVIDEADQLFVPEHVQTVQQIVKMALSDRQILVFSATVSERTKSLAKDMMNHPLEIEVGRDELPASKVEHVYIKSEARDKVDVLRKLVRQEQMKALAFFKGIDTLIEFEEKLTFKRVEAGSLHSETKKEDRATTIKGFRKGDFPVLLATDVAARGLDIKGLTHVIHIDVPQDADQYVHRSGRTGRSGAEGTVISLVTEREERNLKQIARELQLSLVKKELYMGEIVDEGTKEQSRTAKKPSKKPFNKKKKQKGRM
>NZ_CP045272.1|WP_034654747.1|4942487_4943798_-|PAS-domain-S-box-protein
MVKHARKVALRISIIYIIIGAVWILISDNISRTLAQGRFEVYIFFQQYKGWLFILATGIILYGLVYRRAYKLVESQQELVVKEHELQTSNQHYQSLFKHNPDGVFEISKTGEVLLANPEGEAIVGYSSEELQKMKPSALIAAEEFDMCKEYFKEVLNGKGAKFEMNVINRKRERRLLRCSLLPIIVHKQVVGVFMIARDITTYRQDEELMITSEKMSVIGQMAGAVAHEIRNPLTSLKGFVQVMQASKETNDTYLDIMMSEIDRINLISSEMLILGKKQHVSFEKTNLCEILKQVVTLMEAQANLNNVSILLKETAKRPIYVSADSNQLKQVFINVIKNGVEAIMEKGHITITVEEKDTRALIHFEDNGIGMSQERIEQVGTPFYSTKEAGTGLGLAVCYKIMERHQGTMHFKSGKGKGTTVIIDMPIIERNSRLS
>NZ_CP045272.1|WP_034654746.1|4943875_4944628_-|STAS-domain-containing-protein
MSTIKYSPLPVFIMDEEMNILAQSDEAAALFGEVQHFLEIVDEDSQIKARKRLGQKKKIKTELVMHSRKAKMSLYTVNCKWEQGKAHVICVEEDSQIRILSEKIQQHTARLSETDLELLLQKERLEKAMNRVIELSGPFIHLSNNMVLIPLFGDLFEEVIMKNEHRLLRQIDEETVDRVIIDFNGIGQIDERGVAALEHLIWEFQLMGVQIYLTGVTPDHSQWLHQYHFQANVKSISNLGQAIHQFFTTA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP045272_5	5.1\|4931153\|34\|NZ_CP045272\|CRISPRCasFinder	4931153-4931186	34	NZ_CP023064	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence	347341-347374	10	0.706

1. spacer 5.1|4931153|34|NZ_CP045272|CRISPRCasFinder matches to NZ_CP023064 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence) position: , mismatch: 10, identity: 0.706

cggatctggctgagttccgtcaccttccccaggg	CRISPR spacer
tccggcaagctgagttccgtcgccttccacaggt	Protospacer
.  . * .*************.****** ****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

891483 : 900785

Bacillus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013059051.1\|891483_892200_+	response regulator transcription factor	W8CYM9	Bacillus_phage	2.2e-47	42.2
WP_013084918.1\|892199_893972_+	HAMP domain-containing protein	A0A1V0SGX0	Hokovirus	7.5e-25	26.3
WP_034649031.1\|894141_894831_+	peptidoglycan DD-metalloendopeptidase family protein	Q8SBN9	Clostridium_phage	5.2e-14	42.1
WP_016765490.1\|894864_896439_-	phosphoglycerate dehydrogenase	A0A2H4PQU8	Staphylococcus_phage	1.0e-28	30.2
WP_013084915.1\|897034_897610_+	ECF transporter S component	NA	NA	NA	NA
WP_013059046.1\|897688_897937_-	ferredoxin	A0A127AYY7	Bacillus_phage	3.6e-18	54.1
WP_171776634.1\|898194_899244_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_047932134.1\|899267_900785_+	ATP-dependent DNA helicase RecQ	M1PGQ0	Moumouvirus	3.9e-54	31.1

DBSCAN-SWA_2

3012904 : 3021115

Bacillus_virus(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047933921.1\|3012904_3015316_-	S8 family serine peptidase	A0A217EQY2	Bacillus_phage	1.6e-17	36.4
WP_013056909.1\|3016055_3016493_-	RNA-binding protein S1	NA	NA	NA	NA
WP_171777286.1\|3016674_3017496_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	5.1e-93	64.4
WP_025752246.1\|3017530_3018211_-	nicotinate (nicotinamide) nucleotide adenylyltransferase	G3MA22	Bacillus_virus	1.4e-40	42.8
WP_016763992.1\|3018226_3019696_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	1.1e-114	48.4
WP_171777287.1\|3019719_3020268_-	cysteine hydrolase	G3MA16	Bacillus_virus	4.0e-33	43.9
WP_057236878.1\|3020338_3021115_-	NUDIX hydrolase	A0A0E3JJF3	Streptomyces_phage	8.7e-10	41.9

DBSCAN-SWA_3

5013884 : 5022146

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014461934.1\|5013884_5014463_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	9.6e-30	39.8
WP_013081441.1\|5014459_5015497_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F0L1	Synechococcus_phage	1.7e-69	45.6
WP_013055041.1\|5015523_5016939_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	4.3e-55	34.6
WP_013055040.1\|5016914_5019146_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.2e-157	41.3
WP_013055039.1\|5019129_5019816_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_013055038.1\|5019812_5020064_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_013055037.1\|5020071_5020779_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3FGF0	Synechococcus_phage	1.2e-42	40.2
WP_013055036.1\|5020853_5022146_-	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	5.9e-19	25.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP045276

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP045276_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045276_1

99813-99880

Orphan

Consensus_repeat	Method
ATTTGAGGGGGCGTTGAGGGGGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045276_1

>merge|NZ_CP045276|1|99813-99880|CRISPRCasFinder
ATTTGAGGGGGCGTTGAGGGGGTTAGTGGCAAATTAGTTGAAACGTCTGAGGGGACGTTGAAGGGTCG

>NZ_CP045276|1|1|99813-99880|CRISPRCasFinder
ATTTGAGGGGGCGTTGAGGGGGTT	AGTGGCAAATTAGTTGAAAC
GTCTGAGGGGACGTTGAAGGGTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045276.1\|WP_098287937.1\|100048_100303_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045276.1\|WP_043977016.1\|102041_102317_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045276.1\|WP_171779362.1\|88083_88593_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045276.1\|WP_171779366.1\|95232_97167_+\|type-IV-secretion-system-protein-VirB4	unknown	unknown	gnl\|CDD\|274279
NZ_CP045276.1\|WP_098287935.1\|101511_101991_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045276.1\|WP_171779371.1\|102309_103662_+\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NZ_CP045276.1\|WP_171779376.1\|106933_107770_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP045276.1\|WP_171779365.1\|94501_95215_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045276.1\|WP_171779374.1\|105812_106478_+\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|377369
NZ_CP045276.1\|WP_171779369.1\|98889_99777_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045276.1\|WP_171779367.1\|97170_98283_+\|lysozyme-family-protein	unknown	unknown	gnl\|CDD\|381612
NZ_CP045276.1\|WP_171779363.1\|88582_91174_+\|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	unknown	unknown	gnl\|CDD\|378923
NZ_CP045276.1\|WP_171779364.1\|91425_94158_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240430
NZ_CP045276.1\|WP_078082408.1\|91195_91402_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045276.1\|WP_171779368.1\|98297_98879_+\|MerR-family-transcriptional-regulator	unknown	unknown	unknown
NZ_CP045276.1\|WP_171779375.1\|106715_106844_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|372570
NZ_CP045276.1\|WP_171779370.1\|100299_101508_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375981
NZ_CP045276.1\|WP_171779372.1\|103721_104753_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367932
NZ_CP045276.1\|WP_171779373.1\|104830_105820_+\|toprim-domain-containing-protein	unknown	unknown	gnl\|CDD\|379044
NZ_CP045276.1\|WP_097813629.1\|94197_94488_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375135

Protein	Function_ID	Function_description	E-value
NZ_CP045276.1\|WP_171779366.1\|95232_97167_+\|type-IV-secretion-system-protein-VirB4	gnl\|CDD\|274279	TIGR02746, hypothetical_protein, type-IV secretion system protein TraC. The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.	4.74076e-10
NZ_CP045276.1\|WP_171779371.1\|102309_103662_+\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	4.57697e-07
NZ_CP045276.1\|WP_171779376.1\|106933_107770_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	7.53206e-47
NZ_CP045276.1\|WP_097813629.1\|94197_94488_+\|hypothetical-protein	gnl\|CDD\|375135	pfam17332, pXO2-11, Uncharacterized protein pXO2-11. This is a protein of unknown function found in Firmicutes and predicted to contain 2 trans-membrane regions.	5.68769e-29
NZ_CP045276.1\|WP_171779363.1\|88582_91174_+\|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	gnl\|CDD\|378923	pfam12696, TraG-D_C, TraM recognition site of TraD and TraG. This family includes both TraG and TraD as well as VirD4 proteins. TraG is essential for DNA transfer in bacterial conjugation. These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems. This domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore.	3.60618e-31
NZ_CP045276.1\|WP_171779364.1\|91425_94158_+\|hypothetical-protein	gnl\|CDD\|240430	PTZ00473, PTZ00473, Plasmodium Vir superfamily; Provisional.	3.75646e-05
NZ_CP045276.1\|WP_171779375.1\|106715_106844_+\|IS3-family-transposase	gnl\|CDD\|372570	pfam13333, rve_2, Integrase core domain.	0.00774599
NZ_CP045276.1\|WP_171779370.1\|100299_101508_+\|hypothetical-protein	gnl\|CDD\|375981	pfam18555, MobL, MobL relaxases. This family includes members of relaxase enzymes. These enzymes initiate bacterial conjugation contributing to the spread of antibiotic resistance. These MobL relaxases are found mainly in Firmicutes. It is suggested that MobL type relaxases play a prominent role in horizontal gene transfer in Firmicutes bacteria. Family members carry a stretch of relaxase motif III 'HUH' sequence that is characteristic of the HUH endonuclease superfamily essential for enzymatic activity.	1.5506e-110
NZ_CP045276.1\|WP_171779374.1\|105812_106478_+\|restriction-endonuclease	gnl\|CDD\|377369	pfam04471, Mrr_cat, Restriction endonuclease. Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA.	9.89684e-36
NZ_CP045276.1\|WP_171779367.1\|97170_98283_+\|lysozyme-family-protein	gnl\|CDD\|381612	cd16891, CwlT-like, CwlT-like N-terminal lysozyme domain and similar domains. CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain (gamma-d-D-glutamyl-L-diamino acid endopeptidase), and has been implicated in the spread of transposons. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	6.94445e-60
NZ_CP045276.1\|WP_171779373.1\|104830_105820_+\|toprim-domain-containing-protein	gnl\|CDD\|379044	pfam13155, Toprim_2, Toprim-like. This is a family or Toprim-like proteins.	3.84493e-11
NZ_CP045276.1\|WP_171779372.1\|103721_104753_+\|hypothetical-protein	gnl\|CDD\|367932	pfam04420, CHD5, CHD5-like protein. Members of this family are probably coiled-coil proteins that are similar to the CHD5 (Congenital heart disease 5) protein. In Saccharomyces cerevisiae this protein localizes to the ER and is thought to play a homeostatic role.	7.63926e-05

>NZ_CP045276.1|WP_171779369.1|98889_99777_+|hypothetical-protein
MAFKKQLEDYRFNLNRNRSWKYTAMLIFFFIGFLSLLTSKFYLKTEDPLYHTKTYEAVSSNITGTVTIENRVYHPANGSLDMVIKMDQTDEEEVSFVVQEKANPSVKLPVQLLYEDDGYYVVRINDLSPNWEALAFDLYQENEEKETVNVDEVTTNYDTSSTEEIDAHALITTLYSDQRKTKSEEGKGTKSKQEYALLVNDLEKQFVKKKMKNYEKAITIEAKHKRQTQQEMNELLRDMKYQVEEEKADTESKIAMKKDAIQSSDESIQLYEDEQKSLQEKLQKLNEKQQDLAMK
>NZ_CP045276.1|WP_171779368.1|98297_98879_+|MerR-family-transcriptional-regulator
MKNKAALLFGALAVVVAGVTIFNIYLNHNISNTTASKQIQVTNDSLQEENKELKKQLSEVRPSAQEQQKRDYLNTVKQFIDVSYHREKDGFEDRKKIAKAIMDKELYEQFYPSEKFVYGDSYTSIPNDVQLYVQQYDGGQEEVEVIAEFTNHLVIKDENVDDQTHDIIKVSLRKEENKWMVYSIEELKTEIMK
>NZ_CP045276.1|WP_171779367.1|97170_98283_+|lysozyme-family-protein
MHIVLQLIPKKYLIGGTLILLGLSGLLIMSTIVAITGEFEKDSQQSEVTEIEGGGIGVGTANVSPEVMKYQPLLEKYAQKHGLDASYVPIMMALMMQESGGRGNDPMQSSESKCGRVGCIQNPEASIDQGVKHFKSVLEKAHYDLELCLQSYNFGPGFIIFVNKNGGHYTKELAIKFSQIQYQKVKHTGNYHCLRPEAVPYQACYGDIAYKDAVLKYYTGTITADGKPAAPASGGSGGKSGVKVIDAGKTLIGKTRYVFGGGRSQSDINAGRFDCSSFVRWAFEQVGVNVGPMSGVTTDTLKTQGQAINPKDMKPGDVVFFDTYKIDGHVGIYVGDNQFLGCQGKTGVAIASMAKGTYFGERFNGRVKRF
>NZ_CP045276.1|WP_171779366.1|95232_97167_+|type-IV-secretion-system-protein-VirB4
MITLPFRKKEKTPQEIKQKKGYNPYFVAQIQPQGGVSFKENLVRNGDGYSTCIHIYEYPTNVNDFWLEPIMNMPNAITTLDVVSDERKQVVEAINKNMSEQNARHVNAKENIDRMDAQEQYLDMKELYRQVTNGEVIKRIHLRIYIAEKTIPDLEKRLKEVIHHLETHNFRGSIFLNEQEYEWESLVTHFDIQKKYPNKRKGKEIPALALAGGFPFHFTHLDDPYGTYQGTTRTGGSVIFDLFHKDQQRKSYNAVLMGLMGAGKSTFLKKVTTDNAIKGYKIRGFDIVGEFESLVRELGGKQIALDGSEGQINPLQVFKTHEHELNSFTQHLSKLTVFYRFIAPEAKDDELKEYEKLLRKLYIQKQLWNDEKGAINYITGLSPEAYPTFSEFLQLIRQELYADEKTREHHSNLGEYRKRRLELIELNIENLVETYAHLFDGISTIEDFNDEQVVFFSIRHLSKLKDEIAQAQLFNVMSLLWDGMLQNGEPQLDAYTEGTLAFEDAIRYLIVIDEAHHIVNTKKGNEHALDFLTEFSREARKYFAGLIYASHLISDFVPDGSEQTAIEKIKKLFDLTQYKFIMQQDDNNLDTIQRVFKTGITDSELAEIPKLPIGDVLLCIKSVKNILFHIEIDEEEKVLYGGGA
>NZ_CP045276.1|WP_171779365.1|94501_95215_+|hypothetical-protein
MALFDERILEKEKPILKEKKTSNSLLFDEKELDKRIAQTKKKNPFSLLQLPKAEKEKKKEKLPEVKKSVADIIPIIDQTDSGLFQLKDEGGFFGIWQLQSTDINAMHDQEAGRNIYTLAKTYQGDKDPFKIISLNLPVSTQKQQQYLEKKIREANNALSLRFLRKKLKELQYLEWGRTNREYFLFLYGPTELAVKERKDQFMRDIQLAIPLLPVSDEKQINLLYKLYNQNAKLGNKQ
>NZ_CP045276.1|WP_097813629.1|94197_94488_+|hypothetical-protein
MANYNIPKEISTELKINKSLYLFDLLFIIGLLMVTMMLRFFIHPTLQIPFYIFMGIFGLLMIVRPSTNPKKRMYEALLLTLVRKKSTYCAIDRDQE
>NZ_CP045276.1|WP_171779364.1|91425_94158_+|hypothetical-protein
MKDEEILKKLHEFSDYLDVGDIPSYLLRKIGWACIQLLSFLVDGLEGITDSILGVKAFFDSPEIQDFITKIQPFLYVLLAFSFLYIGYMLIIQKKVNREQIMINIFISMAVLLLLNTSMLKADKFTDQAIEAVDLNEKGTVSEKIIKSNITDVAQFDLTKWKSPKLKEPNKVPQKNIMMIDITEKIDKDFQVSKGKDLSKDGKKILENKTEIAPDGKEGLTEIDNGWFDFFPELYYRWSWNFWTIAISLFVIGMTLLFTSIKLAKLCYELGFNAILAQLVAPADVADGQKLKAVLKNIVNTFLVTIMIFISMKVYLMGTVFISDKLEGIPYLIALIAFSIAVVDGPVMCERLFGIDAGLKSGWGALAGGFAMAKGLESGIGMMGRTLKGGANLAKGVGNVGKGLGSGALQTAAGVGGFGKGLATQGNKEKQPALHEEMKKAGMAGEKGNAASKGQNAGNEQKAQQQGLSSTEKQEGGKNTEGNSSEGKGAGQGSSLQDEMEAAGVSTDSQGSTSSIEGGNTSLHDEMQASGYGESANEGIGTSVEGGNASLHDEMQASGYAEGTSEGTGSSVEGGSASLHDEMQASGYAESASEGTGSSVEGGSASLHDEMQASGQNGSTNGGSSSVGKASAPLHGEMQASGQNGSTNGGSSSVGKASASLHDEMQASGHSGSTNGGSSSVGSVSTPVHEEIQTSGYGGSTSEGGSSVGNMSTPVHEEIQTSGYGGSTSEGGSSVGNVSTPVHEEIQTSGYGGSTSEGGSSIGNVSTPVHEEIQTSGYGGSTSEGGSSVESVSYPTPTREPSVSIPTGMDQAQAQVAATQEPRQGKQPIEKDTVPASTDDIPMPDQNRIETRNIAQVVKDNFKGGVGKVKERIDNSQTIHKTKRSYQIGRNTGRDLRNLGSKKRNKPDEK
>NZ_CP045276.1|WP_078082408.1|91195_91402_+|hypothetical-protein
MNSISKELERILEDYAPIVKEGHQVLIGLLDGTVQLEKGQEGEAPVQIRVSPLDERLEMTIDTLFQGM
>NZ_CP045276.1|WP_171779363.1|88582_91174_+|type-IV-secretory-system-conjugative-DNA-transfer-family-protein
MQPNKSIKYVVAEKQVLIPLSACLFVSVLLILNFLFNIMRNLIQTTFSDVFEPQPFHLETSFLTEIHLQQYTPLYGAMCLVAALLTAKFAYNIRSNFKDLNHNQKGSGRFTTRSELKKQYRKVPEKTTTYQGGGGVPVSRIQTYDLIQNWKEYKALKGIEKLLKTHKLFSKRGYLLIDDSPVNNLIIGITRSGKGETFVFPTIDVYSRAEKQPALVLNDPKAEILAASKEILEKRGYHIEVLNLLNPLESMSYNLLEMIKETYKDGDYSTAQALCNTLSYTLYYNPNAKDPFWQQCAMSLCNAMILAVTDKCIKEKEEHKITMYTVANMLSELGSKEVVINKKGDTQNALDLYFDGLPTESVAKMQYATSNFSKGTTRGGIFTQTMNGLSIFTFDEIAKMTSKNSVDLKRVGFGKTIKGTATPLTRLEIIFPDGQTETIKTDGKGLFELNFTSDLKQNDEIILAEKFSDKIVTSSRLETVISINRITKETGNTTFTVEKQHPSIHVKEVTYFTKPIAIFMVTPDYDSSNHVIASIFVRQLYYILAKNASLARGNKCHREVVFLLDEFGNMPAIEGMSNIITVCLGRNIRFNLVIQAYPQLKNKYGDDAATIEGNCGNTIYVLTNNYDTAQEVSKKLGESTINSTSRSGKGLSTDKSKTEGVDNKHLLTPNELMELKEGESVVIRVVKRQDKKRRRVKAHPIYNTGKTSLKYRWEYLGDDFNTDRSILDIDIESLHKEVDPRKLIINNFFSFQQKQQKEESVEKEQESPDTPFSPMTYENWETKSVEEFFSEDPSVFEILKTELPGVMNKTIEEIQQQAMNDFVDEFKILSQNDQLDSNVYQLVETKIETTLAKLQGEVEKQEA
>NZ_CP045276.1|WP_171779362.1|88083_88593_+|hypothetical-protein
MYSQTKVKNQKKAFVVGIEYYEEDLFLEIELGTFHTTQLHAQRIANSVHNVILLENQIVLIFKNADSITLTDDFLKYAFKFRLCTKPTMPPLDISKLTQQEKDDVVFNEAYMVTEEDMKEVQWDINTAFRYLQHQYEARDQTFFSLKSSAYYVIPTSEQIDQEGMRNAT
>NZ_CP045276.1|WP_098287937.1|100048_100303_+|hypothetical-protein
MEIKVRNVDPIAVKKIDEMAKEKKISRSEFLKGQIETFALLQLQKDHEAALEDLIDKNIKMMEKCAVAIERMNGFIEEMVEYEK
>NZ_CP045276.1|WP_171779370.1|100299_101508_+|hypothetical-protein
MSKTKTSPGVLLVTKFATANLKAYQEYVDYVDREDAKKENGAHEKLFTLYQDYLANPDKTSSLFTDESDGLNEQEKKKLKQVFETAQANKSIMWQDVITFHNPWLEEQGLYDSRCHTVDEKKVMDITRQAVNEMLKREKLNGSAVWSAAIHYNTDNIHIHIATVEPHPTRERGMRKQSSLDAMKAKVVNQMTNRRESQKKINELIRKDMVDYKKKDSSLAWRNRELKPLFLMVYNYLPQDKRQWQYSYNTLKPLKPYIDTLSEKYIQKYHSKEYQQLMKTLDEEVNELKKAYGEGKVNQHRYKNYKQNKIDELYKRMGNAFLQEMKSYDKKQQRTQHLIERSKSLKRPKTFQQSAPVHFALKKMEKAFKSEYESWKNQQYYERMQRESQRNQQQHYDDERGY
>NZ_CP045276.1|WP_098287935.1|101511_101991_+|hypothetical-protein
MEKQRMKLAIDEEAQAYIHSYKEEKGLRYTGDAIAQICKEHEIAKSNEWSLKYISEVVSNHLHESLKNEFQNLREEIQTLKGEMTKTKLGANAADKNTQILIEYMNGLFFHHGFKGLMTTSMQEMDSTRVARETVEKRIANQRQKRIDWEESRGKQQSH
>NZ_CP045276.1|WP_043977016.1|102041_102317_+|hypothetical-protein
MFFNKDLVLASIKAVGEDHAIVQYQDKEVEVNLSPEEAKEFHQYVVHQENMLVPMNIKTQKLFVDLEEPWYEQELEELKGISYQEEEDENE
>NZ_CP045276.1|WP_171779371.1|102309_103662_+|ImmA/IrrE-family-metallo-endopeptidase
MSKTYAKKSVEDKRKEVEELTKGMEQKVDQHFHSVEDLKDYLSFMGKFYQYSMSNTALIQKQFRGAQAVGSFKFWKDKGFSVNKGEKGIKILVPNKTVPKFKDEKGKWKSINKATPQEKKLIKEGKKEVTQGRLYFSVGHTFDISQTNAKASDLPKIFPNRWLEGNVEDYKALYKGMEAIAEKNGISIIAPKEELGSAKGVSYTLTKEVALNPRNSEKQNVKTLLHELTHAKLHTKETNLNYTAAEKEFQAEMTAYTVSSYFGIDTSSYSLDYLSNWTKGKTFEDKNKLLKEVHETSVGFIETIEDTLVKERERNQSPEKNDEKQLQADPLSSENVHNKLKEGYGNYIQKQQEESVQNVDSILERVTAEETYYSTKTQAIKNGWMTKEEVVKLEHQVDLMTGRNKKGVTHGQVQEQSLTFQDRMEVGSHMQFQKRTGTAKRKREEPELER
>NZ_CP045276.1|WP_171779372.1|103721_104753_+|hypothetical-protein
MQKVTSLSNDQFKTLVSDKRELKKFMKHPQNEKIEADWANISEKQLQDIPSGAVYLTQSAIGEEKPQVLLVSTDERGQKQAYESEATLDFLKSHDVNPVLEKDRETQLKTSYITFLQAHDKEKPQDIDSMLARVNAENDYVMLKSSALKEKQFTSDQLKGMENELSHQFQSRKQTQEKDRYQEDYKQEVLEVMQQPSEETQYKQLFKQSLLAQLGISDEKDSSKEEKKVAEAEKAPVEKQLKQDTPQEKEQRLAKMKEFEQKHSFDKVYKLKKEVLQELKELNLTDSQREKLTKLEKALDTEKKDYDKQKKEEKSQNGFTKFFARNSGANSSKKQKETQEMER
>NZ_CP045276.1|WP_171779373.1|104830_105820_+|toprim-domain-containing-protein
MGERKHVKEEEVMKARDIDLLSYLEAKGETFVKEGKYYRHTEHDSLLIKGNMYAWNSRNETGYGAISFAQMYYGMSFPQAVLDINKGDYKELSQSHEQPSVSSSKEPFRYPKELEVKDQSKIKDYLIKERKIDSRLVDWLLQKDLIAQDKRNNVVFKWREHGGKGKVIGADRQGTASIKNKRGSFKQVLPNDNPHTGFSVDVGRPNKIHFFESPIDLLSYWSIQENSLQNTRLISMNGLKPKTVAQSYIEARKEGLGIKEMVLAVDNDQGGKEFIDKMNQIVNADLIKADIPKGAKDWNEELKKNGKTIQPVASRLRNKQTEQELSMNG
>NZ_CP045276.1|WP_171779374.1|105812_106478_+|restriction-endonuclease
MDKVFQGVFYLFLIMILVKLSQFAYRVLRERKYRKELAQSGMPYIDKMDGRQFEFYLQALFQQLGYKIQVTPSSGDFGADLVMKGKEKIVIQAKRYSAKNRVSLSAVQEVYAAKAYYKANQAWVVTNSYFTKQAKELATACDVNLVDRADLQKFINEVNPVFKAREIFENITPEPRKCPKCGQDLVVRDGNGTRFFGCSSFPSCRHTEKINKEVSKSRPSV
>NZ_CP045276.1|WP_171779375.1|106715_106844_+|IS3-family-transposase
MKSFWGTFGCEKYYLNKYKTYKELEKEIKEYISFYNNECLQK
>NZ_CP045276.1|WP_171779376.1|106933_107770_-|histidine-phosphatase-family-protein
MKWKKLLVGIVATTMLMTGCNNTSGREGENSDSQTKNNNKVVIYFARHGKTMLNTVDRSQGWIDAPLTPAGVKIAKSLGKGLSDVEFSKAYSSDSGRAIETAELVLENNGQDDLEITKDERLREYNFGTYEGMLNEEMMTVVAEKKGLSLEEYMKFMQKNGFYNSITEFADILSKLDKANGEEGVNWPAEDSKTIKNRLKKSLDNIVSEAEEDGGGNILVVSHGMSIVTLLGELDKNIEVPASGLSNASISKVTYKDGKYTVDSVNDMSYIEKGQKAE

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP045276_1	1.1\|99837\|20\|NZ_CP045276\|CRISPRCasFinder	99837-99856	20	NZ_CP045276	Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence	99837-99856	0	1.0
NZ_CP045276_1	1.1\|99837\|20\|NZ_CP045276\|CRISPRCasFinder	99837-99856	20	NZ_CP018877	Bacillus megaterium strain JX285 plasmid 4, complete sequence	60487-60506	0	1.0

1. spacer 1.1|99837|20|NZ_CP045276|CRISPRCasFinder matches to NZ_CP045276 (Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence) position: , mismatch: 0, identity: 1.0

agtggcaaattagttgaaac	CRISPR spacer
agtggcaaattagttgaaac	Protospacer
********************

2. spacer 1.1|99837|20|NZ_CP045276|CRISPRCasFinder matches to NZ_CP018877 (Bacillus megaterium strain JX285 plasmid 4, complete sequence) position: , mismatch: 0, identity: 1.0

agtggcaaattagttgaaac	CRISPR spacer
agtggcaaattagttgaaac	Protospacer
********************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP045275

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP045275_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045275_1

45764-45863

Orphan

Consensus_repeat	Method
AACCCCCTCAACGTCCCCTCAAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045275_1

>merge|NZ_CP045275|1|45764-45863|CRISPRCasFinder
AACCCCCTCAACGTCCCCTCAAATCAACTACCCGACCCTTCAACGTCCCCTCAGACGTTTCAACAAATTTGCCACTAACCCCCTCAACGCCCCCTCAAAT

>NZ_CP045275|1|1|45764-45863|CRISPRCasFinder
AACCCCCTCAACGTCCCCTCAAAT	CAACTACCCGACCCTTCAACGTCCCCTCAGACGTTTCAACAAATTTGCCACT
AACCCCCTCAACGCCCCCTCAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045275.1\|WP_171779221.1\|52321_54982_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273344
NZ_CP045275.1\|WP_171779218.1\|48508_50443_-\|type-IV-secretion-system-protein-VirB4	unknown	unknown	gnl\|CDD\|274279
NZ_CP045275.1\|WP_078082410.1\|51994_52282_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375135
NZ_CP045275.1\|WP_171779208.1\|38114_39029_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP045275.1\|WP_171779216.1\|46796_47378_-\|MerR-family-transcriptional-regulator	unknown	unknown	unknown
NZ_CP045275.1\|WP_171779215.1\|45898_46786_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP045275.1\|WP_171779212.1\|43647_44127_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235883
NZ_CP045275.1\|WP_171779210.1\|40884_41916_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237177
NZ_CP045275.1\|WP_075422172.1\|43321_43597_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045275.1\|WP_171779213.1\|44130_45351_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375981
NZ_CP045275.1\|WP_171779211.1\|41976_43329_-\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NZ_CP045275.1\|WP_171779286.1\|39807_40761_-\|toprim-domain-containing-protein	unknown	unknown	gnl\|CDD\|379044
NZ_CP045275.1\|WP_171779223.1\|55233_57825_-\|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	unknown	unknown	gnl\|CDD\|378923
NZ_CP045275.1\|WP_171779209.1\|39149_39815_-\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|377369
NZ_CP045275.1\|WP_171779207.1\|37395_37962_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP045275.1\|WP_171779219.1\|50460_51141_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045275.1\|WP_171779220.1\|51275_51932_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180660
NZ_CP045275.1\|WP_171779222.1\|55005_55212_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045275.1\|WP_171779214.1\|45369_45627_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045275.1\|WP_171779217.1\|47392_48505_-\|lysozyme-family-protein	unknown	unknown	gnl\|CDD\|381612

Protein	Function_ID	Function_description	E-value
NZ_CP045275.1\|WP_171779221.1\|52321_54982_-\|hypothetical-protein	gnl\|CDD\|273344	TIGR00927, retinal_rod, K+-dependent Na+/Ca+ exchanger. [Transport and binding proteins, Cations and iron carrying compounds].	2.80268e-07
NZ_CP045275.1\|WP_171779218.1\|48508_50443_-\|type-IV-secretion-system-protein-VirB4	gnl\|CDD\|274279	TIGR02746, hypothetical_protein, type-IV secretion system protein TraC. The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.	3.08127e-11
NZ_CP045275.1\|WP_078082410.1\|51994_52282_-\|hypothetical-protein	gnl\|CDD\|375135	pfam17332, pXO2-11, Uncharacterized protein pXO2-11. This is a protein of unknown function found in Firmicutes and predicted to contain 2 trans-membrane regions.	7.11602e-29
NZ_CP045275.1\|WP_171779208.1\|38114_39029_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.90003e-34
NZ_CP045275.1\|WP_171779215.1\|45898_46786_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00352626
NZ_CP045275.1\|WP_171779212.1\|43647_44127_-\|hypothetical-protein	gnl\|CDD\|235883	PRK06901, PRK06901, oxidoreductase.	0.00944802
NZ_CP045275.1\|WP_171779210.1\|40884_41916_-\|hypothetical-protein	gnl\|CDD\|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	0.00130227
NZ_CP045275.1\|WP_171779213.1\|44130_45351_-\|hypothetical-protein	gnl\|CDD\|375981	pfam18555, MobL, MobL relaxases. This family includes members of relaxase enzymes. These enzymes initiate bacterial conjugation contributing to the spread of antibiotic resistance. These MobL relaxases are found mainly in Firmicutes. It is suggested that MobL type relaxases play a prominent role in horizontal gene transfer in Firmicutes bacteria. Family members carry a stretch of relaxase motif III 'HUH' sequence that is characteristic of the HUH endonuclease superfamily essential for enzymatic activity.	2.0003e-117
NZ_CP045275.1\|WP_171779211.1\|41976_43329_-\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	3.22527e-07
NZ_CP045275.1\|WP_171779286.1\|39807_40761_-\|toprim-domain-containing-protein	gnl\|CDD\|379044	pfam13155, Toprim_2, Toprim-like. This is a family or Toprim-like proteins.	1.20257e-11
NZ_CP045275.1\|WP_171779223.1\|55233_57825_-\|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	gnl\|CDD\|378923	pfam12696, TraG-D_C, TraM recognition site of TraD and TraG. This family includes both TraG and TraD as well as VirD4 proteins. TraG is essential for DNA transfer in bacterial conjugation. These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems. This domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore.	1.07011e-32
NZ_CP045275.1\|WP_171779209.1\|39149_39815_-\|restriction-endonuclease	gnl\|CDD\|377369	pfam04471, Mrr_cat, Restriction endonuclease. Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA.	1.85487e-37
NZ_CP045275.1\|WP_171779207.1\|37395_37962_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	0.000208557
NZ_CP045275.1\|WP_171779220.1\|51275_51932_-\|hypothetical-protein	gnl\|CDD\|180660	PRK06696, PRK06696, uridine kinase; Validated.	1.99684e-104
NZ_CP045275.1\|WP_171779217.1\|47392_48505_-\|lysozyme-family-protein	gnl\|CDD\|381612	cd16891, CwlT-like, CwlT-like N-terminal lysozyme domain and similar domains. CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain (gamma-d-D-glutamyl-L-diamino acid endopeptidase), and has been implicated in the spread of transposons. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	7.19399e-64

>NZ_CP045275.1|WP_171779214.1|45369_45627_-|hypothetical-protein
MEIKIRNVDPIAVKKIDELAKKHKLSRQEFLKGQLETLAFFREQVEREHELESLVEKNMIMMEKCATSMENMNHILLEMIGEVEE
>NZ_CP045275.1|WP_171779213.1|44130_45351_-|hypothetical-protein
MSKAISRTNIVPGVVVKTKFITSHHKAFQQYVEYVDRDEAKQEDRSVAHSFSLYQDYMGNPNKTSSLFTHKYNRLTEEQKADLKESFEEAQKNNSIMWQDVITFHNPWLQEQGIYDARTHTVDERKLMYVTRQAMSKMLERERLNESAVWSAAIHYNTDNLHIHIATVEPNPTRSRGKRKPKTLDMMKSTVVNQIRDRGKNQDRINHLIRKEMVDQKKQDSSFAWRNRELKPLFLMVYNHLPQDKRQWQYSYNTIKPLKPYIDTLSEKYIKKYHQKEYQQLIKNLDKEVKELKKAYGEGTRDKGRYENYKQTKIDDLYKRMGNAFLQEMKAYDRKQQDVKRLLDRKQSRKQTARYKQHVPVHFSLRKIEKAFKSEYESWKNQQHYERLQRETEHDRNQQNDYERGH
>NZ_CP045275.1|WP_171779212.1|43647_44127_-|hypothetical-protein
MEKQRMKLAIEDESKAYIESFKEEHGLRYTGDAIAQICKEHEAAKNNEWSLKYITEVVSHHLHESLKNEFQALREEIHTLKGEITKTKLGANAADKNTQILIEYMNGLFFHHGFKGLMTTSMQEMDSTRVARETVEKRIANQRQKRIDWEESRGKQQSH
>NZ_CP045275.1|WP_075422172.1|43321_43597_-|hypothetical-protein
MFFNKDLVLASIKAVGEDHAIVQYQDKEVEVNLSPEEAKEFHQYVVHQENMLVPMNIKTQKLFVDLEEPWYEQELEELKGISYQEEEGEDE
>NZ_CP045275.1|WP_171779211.1|41976_43329_-|ImmA/IrrE-family-metallo-endopeptidase
MSKTYAKKSVEDKRKEVEELTKGMEKKVEQHFHSVEDLKDYLSFMGKFYQYSMSNTALIQKQFRGAQAVGSFKFWKDKGFSVNKGEKGIKILVPNKTVPKFKDEKGKWKSINKATPQEKKLIKEGKKEVTQGRLYFSVGHVFDIYQTNATANDLPKIFPNRWLEGNVEDYKALYKGMEAIAEKNGISIIAPKEELGSAKGACYPLTKEVALNPRNSERQNVKTLLHEITHAKLHTGESRANYTDAEREFQAEMTAYTVSSYFGIDTSEYSMDYLSHWTKGKSFEDKTKLLKEVHETSVGFIETIEDTLVKEREKNQSPEKNDEKQPQSDPLSPQNVHEKMKEGYEDYKQKQQRESAQNVDSILDRVTAEEKYYSTKTQAIKNGWMTKEEVIKIEHQIDSKVNKNEKGVIDGQVQEPSLTFQDRMEVGSQMQFQKRTGTARRKKEEPELER
>NZ_CP045275.1|WP_171779210.1|40884_41916_-|hypothetical-protein
MQKVTSLSNDQFKTLVSDKRELKKFMKHPQNEKIETDWVNISEKQLQDIPSGAVYLTQSAIGEEKPQVLLVSTDEKGQKQAYESETTLDFLKSHDVNPVLEKDRETQLKTSYITFLQAHDKEKPQDIDSMLARVNAENDYVMLKSSALKENTFTPDQLKGMENELSHQFQARKQAQEKDRYQEDYKQEVLEVMQQPSEETQYKQLFKQSLLAQLGISDEKDSSKEAKKEAEAEKAPVEKQLKQETPQEKEQRLAKMKEFEQKHSFDKVYKLKKEVLQELKELNLTDSQREKLTKLEKALDTEKKDHDKQKKEEKSQNGFTKFFARNNGALSSKKQRDQQEIER
>NZ_CP045275.1|WP_171779286.1|39807_40761_-|toprim-domain-containing-protein
MKARDVDLLSYLEAKGETFVKEGKYYRHTEHDSLLIKGNMYAWNSRNETGYGAISFARMYYGMSFPQAVLDINKGDYKELSQSHEQPSVSPSKESFRYPKELEVKDQSKIKDYLIKERKIDSRLVDWLLQKDLIAQDKRNNVVFKWREHGGKGKVIGADRQGTASISNKRGSFKQVLPNDNPHTGFSIDVGRPNKIHFFESPIDLLSYWSIQENSLQNTRLISMNGLKPKTVAQSYIEARKEGLGIKEMVLAVDNDQGGKEFIDKMNQIVNADLIRADIPKGAKDWNDELKKNGKSIQPVASRLRNKQTEQELSMNG
>NZ_CP045275.1|WP_171779209.1|39149_39815_-|restriction-endonuclease
MDKVFQGVFYLFLIMILVKLSQFAYRVLRERRYMKELAQSGMPYIDKMDGYQFEIYLQALFQQLGYNPQVTKKSGDFGADLVMKGKEKIVIQAKRYGIKNRVSISAVQEVYGAKAYYKANQAWVVTNSYFTKQAKELAAACDVTLLDRADLQKFINEVNPVFKAREIFENITPEPRKCPKCGQDLVVRDGNGTRFFGCSSFPSCRHTEKINKEVSKSRPSL
>NZ_CP045275.1|WP_171779208.1|38114_39029_+|LysR-family-transcriptional-regulator
MEIREILYVKTVADFKNLTKAAEYLHITQPSLSQSIKSIEEKLNTPLFIRSKRGMELTQTGMKFVRDSTLLLSEYNLFISKLKNYSKEALSHSIGLYKLSYTTSINDAIMSFISSNSKDNYIIKVESNENLEMMLLANQLDLAIIKYPPISKRQSKLSYDVLFKEKLYVLMSQSNPLASYDKISVKNLEGNKLITSDINEYPYIMTHEVLKNAGIDLEIHTYTNYSNLSMILDLVEKDMGIAFGTKDICTYFDRKGINYVPLIEDYFYDICIVQNEIDKRRGKNNVLIDYIYNFLGLNLETRNY
>NZ_CP045275.1|WP_171779207.1|37395_37962_-|GNAT-family-N-acetyltransferase
MININYKIITTDNIDFLEELCNQLMRFQADHATIRPDIMASMNYNNRLKPEYANTLRKHMVVAYDEERPVGFAFATIENVTEENLKGKPGWAAELDGIGFYPENYEVPKTIGTFKILYVDDEYRSFSIGKHLSNMTMDWLNSHEDVDDLWVYVANGNEIVGKLYEKYGFKLSHSVFNGFINAYCQKKK
>NZ_CP045275.1|WP_171779215.1|45898_46786_-|hypothetical-protein
MAFKKQFEDYRFNLNRNRSWKYTAMLIFFFIGFLSLLTSKFYLKTEDPLYHTKTYEAISSNITGTVTIENRVYHPANASLDMVIKMDQTDGEEVSFVAQEKANPNIKLPVHLLYEDDGYYVVRISDLSPNWEALAFDLYQENEEKETVNLDDVTNDSETDSTEEIDAHALITTLYSDQRKTKSEEGKETKSKQEYALLVNNLEKQFVKKKMKNYEKAITVEAKHKRQTQQEVNELQRDMKYQVNEEKADTESKIAMKKDAIQSSDESIQLYEDEQKSLQEKLQKLNEKQQDLAMK
>NZ_CP045275.1|WP_171779216.1|46796_47378_-|MerR-family-transcriptional-regulator
MKNKAALLFGALAVVVAGVTIFNIYLNHNISNTTASKQIQVTNESLQKENKELKKQLSEVRPSAQEQQKRDYLNTVNQFIDVSYHREKDGFEDRKKTAKSIMDKELYEQFYPSEKFVYGDSYTSIPNDVQLYVQQYDGGQEEVEVIAEFTNHLVIKDENVDDQTHDIIKVSLRKEENKWVVYSIEELKTEIMK
>NZ_CP045275.1|WP_171779217.1|47392_48505_-|lysozyme-family-protein
MHIVLQLIPKKYLIGGTLILLGLSGLLIMSTIVAITGEFEKDSQQSEVTEIEGGGIGAGTANVSPEVMRYQPLLEKYAQKHGLDASYVPIMMALMMQESGGRGNDPMQSSESKCGSVGCIQNPEASIDQGVKHFKDVLEKAKYDLKLCLQSYNFGGGFINYVMKNGGKYTKELAISFSQLQYQKVKHTGNYHCIRPEAIPYSACYGDFMYVDAVLKYYTGTITADGKPAAPASGGSGGKSGVKVIDAGKTLIGKTRYVFGGGRSQSDINAGRFDCSSFVRWAFEQVGMNVGPMSGVTTDTLKTQGQAINPKDMKPGDVVFFDTYKIDGHVGIYVGNNQFLGCQGKTGVAIASMAKGTYFGERFNGRVKRF
>NZ_CP045275.1|WP_171779218.1|48508_50443_-|type-IV-secretion-system-protein-VirB4
MITLPFRKKEKTPQEIKQKKGYNPYFVAQIQPQGGVSFKENLVRNGDGYSTCIHIYEYPTNVNDFWLEPIMNMPNAITTLDVVSDERKQVVEAINKNMSEQNARHVNAKENIDRMDAQEQYLDMKELYRQVINGEVIKRIHLRIYIAEKTIPDLEKRLKEVIHHLETHNFRGSIFLNEQEYEWESLVTHFDIQKKYPNKRKGKEIPALTLAGGFPFHFTHLDDPYGTYQGTTRTGGSVIFDLFHKDEKRKSYNAVLMGLMGSGKSTFLKKVTTDNAIKGYKVRGFDIVGEFESLVRELGGKQTALDGSEGQINPLQVFKTHKVERSSFTQHLSKLTVFYRFIAPEARDDELKEYEKLLRKLYIQKELWSDEKGVENQITGLPSEAYPIFSDFLKLIRKELYEDIETRRHHVHLGEYRKHRLELIELNIENIVENYGHLFDGISTIEDFNDEQVVFFSIRHLSKLKNEIAQAQLFNVMSLLWDEMLQNGQPQLEAYTKGELPFEDAIRYLIVIDEAHRIVNTKKGSEHALDFLTEFSREARKYFAGLIYASHLITDFVPEGSEQTAIEKIKTLFDLTQYKFIMNQDDNNLDTIQRVFKTGITDSELAEIPRLPVGDVLLCIKSVKNILFHIEIDEEEKVLYGGGA
>NZ_CP045275.1|WP_171779219.1|50460_51141_-|hypothetical-protein
MALFDERILEKEKPTSITAVPKGKIATTSLLFDEKEMDKQISHAKKKKNKPPEVKKSVADIIPIIDQTDSGLFQLKDDGGFFGIWQLQSTDINAMHDQEAGRNIYTLARTYQGDKDPFKIISLNLPVSTQKQQQYLEKKIREAPNALSLRFLRKKLKELQYLEWGRTNREYFLFLYGPTELAVKERKDQFMRDIQLAVPLLPVSDEKQINLLYKLYNQNAKLGNKQ
>NZ_CP045275.1|WP_171779220.1|51275_51932_-|hypothetical-protein
MLRKKLISELANEVLSLKTRHPIRVGISGITSSGKTTLANELTEELQNRGKKVIRTSIDHFHNPRSIRYRQGKDSALGYYQDAHDYESFKHKLLIPLGPEGNCHYQAASLDLATDQYVKPNIQLATKDMVLIVDGTFLFKKQLCNLYDFKIFVSTEFELARKRGAKREEQAFGSYEKAEEMFIKRYHAASKIYLDEHQPQFSADVVINNNDLNDPYFI
>NZ_CP045275.1|WP_078082410.1|51994_52282_-|hypothetical-protein
MANYNIPKEISTELKINKSLYLFDLLFIIGLLMVTMMLRFFIHPTLQIPFYIFMGIFGLLMIIRPSTNPKKRMYEALLLTLVRKKSTYCAIDRDE
>NZ_CP045275.1|WP_171779221.1|52321_54982_-|hypothetical-protein
MKDEEILKKLREFSEYLDVGNIVTYMLRKVGWACIQLLSFLVDGLEGITDSILGIKTFFNSPEIQDFITKTQPFLYVLLAFSFLYIGYMLIIQKKVNREQIMINIFISMAVLLLLNTSMLKADKFTDQAIEAVDLNEKGTVSEKIIKSNITDVAQFDLTRWKSPKLKESNKVPQKNIMMIDITEKIDDNFKISKDKELSKEGKKIVTNKADITPDGKEGLVELNNGWFDFFPELYYRWSWNFWTIAISLFVIGMTLLFTSIKLAKLCYELGFNAILAQLVAPADVADGQKLKAVLKNILNTFLVTIMIFISMKVYLMGTVFISDKLEGIPYLIALIAFSIAVVDGPIMCERLFGIDAGLKSGWGALAGGFAMAKGLESGIGMMGRTLKGGANLAKGVGNVGKGLGSGALQTAAGVGGFGKGLATQGNKEKQPALHEEMKKAGMAGEKGNTASKGQNAGNEQKAQQQGLSSTGKQEGGKNTEGNSLEGKGAGQGQGSSLQDEMQAAGVSTDSQGSTSSVEGGNTSLHDEMKASGYGESANEGTGSSVEGGNASLHDEMQASGYSKSANEGTGSSVEGGGASLHDEMQASDQSERASEDTGSSVESGSASLHDEMQASDQSERASEGTGSSVESGGASLHDEMQASGHSGNTNGGSSSVGKASASLHDEMQASGHSGSTNGGSSSVGKASTPLHGEMQASGHSGSTNGASSSVGSVSTPVHEEIQTSGYGGSTSEGGSSVGNVSTPVHEEIQTSGYGGSTSEGGSSIESVSYPTPTREPSVSIPTGMDQAQAQVAATQEPRQGKQQIEKDIVPASTDDIPMPDQNRIETRNIAQVVKDNFKGGVGKVKERIDNSQTIHKTKRSYQIGRNTGRDLRNLGSKKRNKPEEK
>NZ_CP045275.1|WP_171779222.1|55005_55212_-|hypothetical-protein
MNSISKELERILEDYAPIVKEGHQVLIGLLDGTVQLEKGQEGEAPVQIRVSPLDERLEITVDALFQGM
>NZ_CP045275.1|WP_171779223.1|55233_57825_-|type-IV-secretory-system-conjugative-DNA-transfer-family-protein
MQPNKSIKYVVAEKQVLIPLSACFFVSILLILNFLFNMMRNLVQTTFSDVFEPQPFHLDTSFLTEIHLQQYAPLYGAMCLVAALLTAKFAYNIRSNFKDLNHNQKGSGRFTTRRELKKQYRKVPEKTTTYQGGGGVPVSRIQTYDLIQTWKEYKALKGIQKLLHTHRFFTKKSYMLIDDTPVNNLIIGITRSGKGETFVFPTIDIYSRAEKQPSLVCNDPKGELLAASKNTLEERGYHVEVLNLLNPLESMSYNLLEMIKETYKDGDYSTAQALCNTLSYTLYYNPNAKDPFWQQCAMSLCNAMILAVTDKCIKEEEENKITMYTVANMLSELGSKEVVINKKGDTQNALDLYFDGLPTESVAKMQYATSNFSKGTTRGGIFTQTMNGLSIFTFDEIAKMTSKNSVDLKRVGFGKTIKGKAAPLTRLEMTFPDGQKETIKTDAKGLFEVNFTSEVKQNDEIILTEKFSDKIVTSSRLQTVISINRITKETGATTFTVEKQHPTIYVKEVTYFTKPIAIFMVTPDYDSSNHVIASIFVRQLYYVLSKNASLARGNKCHREVVVLLDEFGNMPAIEGMSNIITVCLGRNIRFNLVIQAYAQLKNKYGDDAEIIEGNCGNTIYILTNNYETAKTISQKLGDGTINSTSRSGKGLSTDKSKTEGVDGKPLLTPNELMELKEGESVVVRVVKRQDKSRRRIKAHPIYNTEKTALKYRWEYLGDDFNTDRSILDIDIESLHKEVDPRKLIIDNFFTFQQKQQKEESVEKEQESLDTPFSPMTYENWGTKSVEEFFSEDPSVFEILKTELPGVMNKTIEEIQQQAMNDFVDEFKILSQNDQLDSNVYQLVETKIETTLAKLQGEVEKQEA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP045275_1	1.1\|45788\|52\|NZ_CP045275\|CRISPRCasFinder	45788-45839	52	NZ_CP045276.1	99837-99888	1	0.981

1. spacer 1.1|45788|52|NZ_CP045275|CRISPRCasFinder matches to position: 99837-99888, mismatch: 1, identity: 0.981

caactacccgacccttcaacgtcccctcagacgtttcaacaaatttgccact	CRISPR spacer
caactacccgacccttcaacgtcccctcagacgtttcaactaatttgccact	Protospacer
**************************************** ***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP045275_1	1.1\|45788\|52\|NZ_CP045275\|CRISPRCasFinder	45788-45839	52	NZ_CP045275	Bacillus megaterium strain FDU301 plasmid pFDU301C, complete sequence	45788-45839	0	1.0
NZ_CP045275_1	1.1\|45788\|52\|NZ_CP045275\|CRISPRCasFinder	45788-45839	52	NZ_CP026738	Bacillus megaterium strain YC4-R4 plasmid unnamed2	19097-19148	1	0.981
NZ_CP045275_1	1.1\|45788\|52\|NZ_CP045275\|CRISPRCasFinder	45788-45839	52	NZ_CP045276	Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence	99837-99888	1	0.981
NZ_CP045275_1	1.1\|45788\|52\|NZ_CP045275\|CRISPRCasFinder	45788-45839	52	NZ_CP018877	Bacillus megaterium strain JX285 plasmid 4, complete sequence	60487-60538	2	0.962

1. spacer 1.1|45788|52|NZ_CP045275|CRISPRCasFinder matches to NZ_CP045275 (Bacillus megaterium strain FDU301 plasmid pFDU301C, complete sequence) position: , mismatch: 0, identity: 1.0

caactacccgacccttcaacgtcccctcagacgtttcaacaaatttgccact	CRISPR spacer
caactacccgacccttcaacgtcccctcagacgtttcaacaaatttgccact	Protospacer
****************************************************

2. spacer 1.1|45788|52|NZ_CP045275|CRISPRCasFinder matches to NZ_CP026738 (Bacillus megaterium strain YC4-R4 plasmid unnamed2) position: , mismatch: 1, identity: 0.981

caactacccgacccttcaacgtcccctcagacgtttcaacaaatttgccact	CRISPR spacer
caactatccgacccttcaacgtcccctcagacgtttcaacaaatttgccact	Protospacer
******.*********************************************

3. spacer 1.1|45788|52|NZ_CP045275|CRISPRCasFinder matches to NZ_CP045276 (Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence) position: , mismatch: 1, identity: 0.981

caactacccgacccttcaacgtcccctcagacgtttcaacaaatttgccact	CRISPR spacer
caactacccgacccttcaacgtcccctcagacgtttcaactaatttgccact	Protospacer
**************************************** ***********

4. spacer 1.1|45788|52|NZ_CP045275|CRISPRCasFinder matches to NZ_CP018877 (Bacillus megaterium strain JX285 plasmid 4, complete sequence) position: , mismatch: 2, identity: 0.962

caactacccgacccttcaacgtcccctcagacgtttcaacaaatttgccact	CRISPR spacer
caactacccgacccttcaacgtcccctcagatgtttcaactaatttgccact	Protospacer
*******************************.******** ***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

71905 : 79515

Geobacillus_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_095380539.1\|71905_72130_+	helix-turn-helix transcriptional regulator	S5MBY6	Brevibacillus_phage	1.0e-19	58.1
WP_171779234.1\|72372_72693_-	hypothetical protein	NA	NA	NA	NA
WP_171779235.1\|72879_73575_-	hypothetical protein	Q0H249	Geobacillus_phage	9.5e-32	39.1
WP_171779236.1\|73571_74705_-	chromosome partitioning protein ParA	Q0H250	Geobacillus_phage	9.6e-58	34.7
WP_171779237.1\|74717_75017_-	hypothetical protein	NA	NA	NA	NA
WP_171779238.1\|75561_76044_-	hypothetical protein	NA	NA	NA	NA
WP_097825476.1\|76071_76248_-	hypothetical protein	A0A1P8CWV7	Bacillus_phage	7.2e-13	62.7
WP_171779239.1\|76384_76819_-	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_171779240.1\|77012_77345_-	YolD-like family protein	U3PG23	Staphylococcus_phage	2.4e-09	36.7
WP_171779241.1\|77358_78624_-	damage repair protein	O64031	Bacillus_phage	1.3e-103	47.0
WP_171779242.1\|78969_79515_+	hypothetical protein	A0A2K9V3H4	Faecalibacterium_phage	2.2e-23	39.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP045272

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP045276

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP045275

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection