CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP048838	[Clostridium] innocuum strain ATCC 14501 chromosome, complete genome	4 crisprs	cas14j,cas14k,PD-DExK,csa3,PrimPol,cas3,WYL,DEDDh,DinG,RT,c2c10_CAS-V-U3,cas5,cas8c,cas7,cas4,cas2	0	4	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP048838_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048838_1

1263675-1264326

Orphan

Consensus_repeat	Method
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	CRISPRCasFinder
ATTTAGATCNACAAGCTCCGCGAAAGAGCTTGAC	CRT
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	PILER-CR

9 spacers

PrimPol

The CRISPR arrays of NZ_CP048838_1

>merge|NZ_CP048838|1|1263675-1264326|CRISPRCasFinder,CRT,PILER-CR
TGTTTGATCGCCAAGCTCTGAAAAAGAGCTTGGCGGACAATTCAATCATACTGTCGATAAAGGCTGGAAATTTAGATCAACAAGCTCCGCGAAAGAGCTTGACAGAAGAAACTGTGAAATATTGTAGGCATGATGTTATTTAGATCAACAAGCTCCGCGAAAGAGCTTGACGAAAATCTACAATTATTGTTTTACACGATTGGAATTTAGATCAACATGCTTCGCGAAAGAGCTTGACTTGCTTTGCCATAATTACTCCAAATAATTACGATGATTTAGATCAACAAGCTCCGCGAAAGAGCTTGACTCTTTGATCAGATCCACTAGGAACTGGATCAGGATAGAATTTAGATCCACAAGCTCCGCGAAAGAGCTTGACAAGAACTGGCAGTTACAGAGGGTGAGTAATGTGTGGATTTAGATCCACAAGCTCCGCGAAAGAGCTTGACCTCGGCTCAAATACTCCGCAAAATCCAGCGTTATATTTAGATCCACAAGCTCCGCGAAAGAGCTTGACCGGTAATATCCTGAAATAACTTTAATAGGATACGATTTAGATCCACAAGCTCCGCGAAAGAGCTTGACATTAACCAATATTCGTCGTGTGTATATGATATTATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC

>NZ_CP048838|1|1|1263675-1264326|CRISPRCasFinder
TGTTTGATCGCCAAGCTCTGAAAAAGAGCTTGGC	GGACAATTCAATCATACTGTCGATAAAGGCTGGAA
ATTTAGATCAACAAGCTCCGCGAAAGAGCTTGAC	AGAAGAAACTGTGAAATATTGTAGGCATGATGTT
ATTTAGATCAACAAGCTCCGCGAAAGAGCTTGAC	GAAAATCTACAATTATTGTTTTACACGATTGGA
ATTTAGATCAACATGCTTCGCGAAAGAGCTTGAC	TTGCTTTGCCATAATTACTCCAAATAATTACGATG
ATTTAGATCAACAAGCTCCGCGAAAGAGCTTGAC	TCTTTGATCAGATCCACTAGGAACTGGATCAGGATAGA
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	AAGAACTGGCAGTTACAGAGGGTGAGTAATGTGTGG
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	CTCGGCTCAAATACTCCGCAAAATCCAGCGTTAT
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	CGGTAATATCCTGAAATAACTTTAATAGGATACG
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	ATTAACCAATATTCGTCGTGTGTATATGATATT
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC

>NZ_CP048838|1|1|1263675-1264326|CRT
TGTTTGATCGCCAAGCTCTGAAAAAGAGCTTGGC	GGACAATTCAATCATACTGTCGATAAAGGCTGGAA
ATTTAGATCAACAAGCTCCGCGAAAGAGCTTGAC	AGAAGAAACTGTGAAATATTGTAGGCATGATGTT
ATTTAGATCAACAAGCTCCGCGAAAGAGCTTGAC	GAAAATCTACAATTATTGTTTTACACGATTGGA
ATTTAGATCAACATGCTTCGCGAAAGAGCTTGAC	TTGCTTTGCCATAATTACTCCAAATAATTACGATG
ATTTAGATCAACAAGCTCCGCGAAAGAGCTTGAC	TCTTTGATCAGATCCACTAGGAACTGGATCAGGATAGA
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	AAGAACTGGCAGTTACAGAGGGTGAGTAATGTGTGG
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	CTCGGCTCAAATACTCCGCAAAATCCAGCGTTAT
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	CGGTAATATCCTGAAATAACTTTAATAGGATACG
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	ATTAACCAATATTCGTCGTGTGTATATGATATT
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC

>NZ_CP048838|1|1|1263812-1264326|PILER-CR
ATTTAGATCAACAAGCTCCGCGAAAGAGCTTGAC	GAAAATCTACAATTATTGTTTTACACGATTGGA
ATTTAGATCAACATGCTTCGCGAAAGAGCTTGAC	TTGCTTTGCCATAATTACTCCAAATAATTACGATG
ATTTAGATCAACAAGCTCCGCGAAAGAGCTTGAC	TCTTTGATCAGATCCACTAGGAACTGGATCAGGATAGA
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	AAGAACTGGCAGTTACAGAGGGTGAGTAATGTGTGG
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	CTCGGCTCAAATACTCCGCAAAATCCAGCGTTAT
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	CGGTAATATCCTGAAATAACTTTAATAGGATACG
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC	ATTAACCAATATTCGTCGTGTGTATATGATATT
ATTTAGATCCACAAGCTCCGCGAAAGAGCTTGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048838.1\|WP_002608173.1\|1250968_1251358_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223299
NZ_CP048838.1\|WP_002608186.1\|1270171_1272133_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224037
NZ_CP048838.1\|WP_002608182.1\|1264692_1265862_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|181749
NZ_CP048838.1\|WP_002608176.1\|1252951_1254268_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NZ_CP048838.1\|WP_002608183.1\|1265858_1266458_+\|type-1-glutamine-amidotransferase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|367568
NZ_CP048838.1\|WP_002608188.1\|1273421_1274243_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133382
NZ_CP048838.1\|WP_002608172.1\|1249928_1250954_+\|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl\|CDD\|239203
NZ_CP048838.1\|WP_002608179.1\|1258471_1259344_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048838.1\|WP_002608191.1\|1278040_1279015_+\|helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP048838.1\|WP_002608180.1\|1260079_1262077_+\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP048838.1\|WP_002608184.1\|1266680_1268015_+\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NZ_CP048838.1\|WP_002608185.1\|1268137_1269679_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NZ_CP048838.1\|WP_002608175.1\|1252111_1252930_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP048838.1\|WP_002608178.1\|1255449_1257753_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP048838.1\|WP_002608177.1\|1254423_1255197_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|225070
NZ_CP048838.1\|WP_002608190.1\|1276271_1278032_+\|DEAD/DEAH-box-helicase-family-protein	PrimPol	COG4951_PrimPol_CAS-I:CAS-III	gnl\|CDD\|227287
NZ_CP048838.1\|WP_002608181.1\|1262153_1263554_-\|glutamate-synthase	unknown	unknown	gnl\|CDD\|239202
NZ_CP048838.1\|WP_002608187.1\|1272870_1273350_-\|tRNA-(N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase-TrmO	unknown	unknown	gnl\|CDD\|187753
NZ_CP048838.1\|WP_002608174.1\|1251572_1252058_+\|DUF4358-domain-containing-protein	unknown	unknown	gnl\|CDD\|379531
NZ_CP048838.1\|WP_002608189.1\|1274624_1276097_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048838.1\|WP_002608173.1\|1250968_1251358_+\|hypothetical-protein	gnl\|CDD\|223299	COG0221, Ppa, Inorganic pyrophosphatase [Energy production and conversion].	0.00345968
NZ_CP048838.1\|WP_002608186.1\|1270171_1272133_+\|hypothetical-protein	gnl\|CDD\|224037	COG1112, COG1112, Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair].	3.72962e-21
NZ_CP048838.1\|WP_002608182.1\|1264692_1265862_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|181749	PRK09276, PRK09276, LL-diaminopimelate aminotransferase; Provisional.	2.2847e-159
NZ_CP048838.1\|WP_002608176.1\|1252951_1254268_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	1.69198e-110
NZ_CP048838.1\|WP_002608183.1\|1265858_1266458_+\|type-1-glutamine-amidotransferase-like-domain-containing-protein	gnl\|CDD\|367568	pfam03575, Peptidase_S51, Peptidase family S51.	5.35998e-40
NZ_CP048838.1\|WP_002608188.1\|1273421_1274243_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	2.78879e-38
NZ_CP048838.1\|WP_002608172.1\|1249928_1250954_+\|alpha-hydroxy-acid-oxidizing-protein	gnl\|CDD\|239203	cd02809, alpha_hydroxyacid_oxid_FMN, Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate dehydrogenase (MDH), and long chain hydroxyacid oxidase (LCHAO). In green plants, glycolate oxidase is one of the key enzymes in photorespiration where it oxidizes glycolate to glyoxylate. LMO catalyzes the oxidation of L-lactate to acetate and carbon dioxide. MDH oxidizes (S)-mandelate to phenylglyoxalate. It is an enzyme in the mandelate pathway that occurs in several strains of Pseudomonas which converts (R)-mandelate to benzoate.	7.21024e-76
NZ_CP048838.1\|WP_002608191.1\|1278040_1279015_+\|helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	5.60023e-22
NZ_CP048838.1\|WP_002608180.1\|1260079_1262077_+\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	6.30338e-113
NZ_CP048838.1\|WP_002608184.1\|1266680_1268015_+\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	1.07821e-143
NZ_CP048838.1\|WP_002608185.1\|1268137_1269679_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NZ_CP048838.1\|WP_002608175.1\|1252111_1252930_+\|hypothetical-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	2.00013e-15
NZ_CP048838.1\|WP_002608178.1\|1255449_1257753_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.81171e-90
NZ_CP048838.1\|WP_002608177.1\|1254423_1255197_+\|amidohydrolase-family-protein	gnl\|CDD\|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	9.28109e-14
NZ_CP048838.1\|WP_002608181.1\|1262153_1263554_-\|glutamate-synthase	gnl\|CDD\|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	1.88701e-156
NZ_CP048838.1\|WP_002608187.1\|1272870_1273350_-\|tRNA-(N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase-TrmO	gnl\|CDD\|187753	cd09281, UPF0066, Escherichia coli YaeB and related proteins. Uncharacterized protein family UPF0066. This domain includes Escherichia coli YeaB, Archeoglobus fulgidus AF0241, and Agrobacterium tumefaciens VirR. Proteins with this domain are probable S-adenosylmethionine-dependent methyltransferases but they have not been functionally characterized and the substrate is unknown.	2.39256e-43
NZ_CP048838.1\|WP_002608174.1\|1251572_1252058_+\|DUF4358-domain-containing-protein	gnl\|CDD\|379531	pfam14270, DUF4358, Domain of unknown function (DUF4358). This domain family is found in bacteria, and is approximately 110 amino acids in length.	3.85696e-14
NZ_CP048838.1\|WP_002608190.1\|1276271_1278032_+\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|227287	COG4951, COG4951, Uncharacterized protein conserved in bacteria [Function unknown].	7.32717e-66

>NZ_CP048838.1|WP_002608181.1|1262153_1263554_-|glutamate-synthase
MKYVCEICGYMYDEAVEGTSWVNLDSTWKCPLCTAPKECFKKVASEEDASATSKSNDATSLAIQKNTKKEDTLETSMSLIHEMAIHNTSRIEAMRTRKSVPGWDDILLLGGQLAHPPLADKADVDTTTIIGKNARKPMVLDHAVYVSHMSFGALSKEAKTALAKGTAAVHTAQCSGEGGILPDEIDHAYKYIFEYVPNKYSVTDENLKRSDAIEIKIGQGSKPGMGGHLPAEKVTEEISAIRGKPLHQDIISPSKFDEIKTKDDLKQLVTSLRERSDGRPIGIKIAAGHIEADLEWIAYAQPDFITIDGRGGATGASPKYLKDNSTVPTVYALARARAYMNQHHMTQELIITGGFRTSGEMIKALAMGADAIAIASAAMIAIGCQQYRICHNGKCPMGIATQDPELRKNFSIDKGAKRLENYLHVLWEELKSFARISGHTSIHDLSRDDLCTTSSEISNHTDIPHC
>NZ_CP048838.1|WP_002608180.1|1260079_1262077_+|S9-family-peptidase
MKDTIKLKDFLDFTYLSNLSFAPDEEHGVFVGSKCVEKDNSYQMKLYLTDGDTVRQLTSHGKEQLYLWDDNETVLFANMRDEEDRKAVENGEERTCFYRISIHGGEAVKAFTIPLQVTSIKKAADGEYVFCADFHLEYSRMYQMNADEKEKILQEKKDMQDYEVLDELPFYGNGMGYTNKKRNSLFLYHEHDDEILRISEETCNVYDVELSDNHEIVYYTGESYACKPINKEGVYSYYRNTGEHREILPAGQWSIGKILPWKDNIMMLASEQKRYGLNENGMFYQLDPNSGVVELFASYEDAVGSSVGSDCRYGGGKSICLYKDTVYFITTLFNRSSVYALHSDGSITPVYDREGSVDVIALAKDRLYFAGMQDMRLQELYSYDMHGKSCRQLTGFNEEFYAEKDIRPCVPCNFTQDGMELYGWVLEPKGFDPKKTYPAILDIHGGPKTVYGEVYYHEMQVWANQGYFVFFMNPRGGDGRGNSFADIRGKYGTIDYEDLMKFTDEVLKKYPAIDTARVGVTGGSYGGFMTNWIIGHTDRFKAAASQRSISNWISFAHTSDIGEMFGADQQGADTWKNVDKLWWHSPLKYANQCTTPTLFIHSDEDFRCPYSEGMQMYSALCEHGVATRLCMFKGENHELSRSGKPRHRVKRLKEITTWMDTYLKD
>NZ_CP048838.1|WP_002608179.1|1258471_1259344_+|hypothetical-protein
MHRNARGLELAKWRFYFEGGDAGAVVDELQYYQNTDGGFAHALEADCWNPASAPSQMFYAIHILHELEYQDKTHPVIQGMLRYLESGKDMEDGFWISILSSNNEYPHAPWWTKTEKKTFDVYMPNADICWFILKFAQKDSSLYTKAESMVQRMMVLFLSQKEVEPHSLESMMFLLRELQKTGSFCGPQADAVAAHGIQLMRGLIEEDPDNWNAYCITPSFFIHDRLHPLYPEYSNLLKLEVQRITETRDAEGCWDINWVWQGYENEYRLSANWWKSSVTMQKLMLYETFA
>NZ_CP048838.1|WP_002608178.1|1255449_1257753_+|EAL-domain-containing-protein
MYSLGKKQKTHTKLTIGILILMIITMIGLSSMMIQQSKSLIMNETQRYLSELSKQTSSRVDQNIAKNIAQLREVSANLSEIATTDAVGQTIIDSVLKENDFSWIGYVDMNGLLHVKNHKTVSVTKLEIVLDALHKQKSGVSKQLETLYDETGILYAVPFYVQGHIKGAMVAWSNTETLQLLSDTDTFNGVGFSYIISQDGDFIMHSSNQYAVFLKNDFYKSIQDVADIDSGSSLSKLKSDIHYRKSGTIHYTVHQDVRGEPEERTLYYTPLQEGSWYLLSIAPSMIYAKNIQDYTNFSIMINVFIFLVFGILILYILFTNTKFNKEIYRVAYVDPVTNGFTAPRFEKELQRILENFQSFAFVTVDIRKFKLINDSFGSRDGDRVLQYVHDCLQSYLKEGEFLARISSDTYNLVLFTTDTAEIRERLEAMTDKVNSYNQSKEQTYYLPLDCGIYIVTDSSIDIVNIRDRANTARKNNKDMISRHMCSCVFYDDYDRVQMLKEKKMENSMQQALENGEFIVYLQPKINLEKSEIVGAEALVRWNSQDGLISPGEFIPFFEKNGFIVKLDLYVFDCVCRLLQDWENRGIAPIPISVNLSRNHLLDPQFLKKYEVIQKTYGIASHLLEFELTETVVFENLELLKNVIAQIHAAGFQCSMDDFGSGYSSLNVLKEIPVDILKLDGAFFDKEGDPRGNDVVETAIELARKLGMKTVAEGVETFTQVEFLRNANCDMVQGYVFSKPLSIENFEVLAFSARKAKTLHEFQIRQDG
>NZ_CP048838.1|WP_002608177.1|1254423_1255197_+|amidohydrolase-family-protein
MDSEQKRRILDAHMHLPVQGISLPEKKEILLKEMQKNGIDEGIVISDSAITSEIGSLKDCLELFSDTCNVHVVGEISPFFNYKEQCKLLDTALSEKKIVGIKLFCGHESFYLSDNILGPVYALAETYNVPVLFHSEKDSSQYASYFAVCEAVRQHPNITFVCCHCHYPNVEACFQRYKNVNNIVFDISSIADVQMTADMRKAVQSELQRHPDAIMFGSDYAGCSQADHLDFAMSLAVSDDIRSRLLYKTAYRVFHLA
>NZ_CP048838.1|WP_002608176.1|1252951_1254268_+|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MKVTIKKTGINGEGIGYIDRMPVFVPQALIGEEVEIRIVDKQKRYATAELLRVVKSSKNRIRPKCFIQNTCGACPLMIARYPVQLEYKQDLLKQSLIKYAQIDPRKVARVKASEDVFGYRNQFKLPCAMEEGRLVSGLFMPNSNYFIDVKKCWIHEDGLERVRMDIMHVLNTHGCVSYNPHDKKGIRNLVVRGFDNRYQCTIVTGNDELDERLISDLMRIKGLTSLWQSIHTIKKTPEVFGNKMMHLAGETSLAMELDGLKLQISPRSFFQLNSKQAVQLYRTIASMVKEDNELIVEAYSGIGAISLYLKDKAKEIIGIESIKDAVVNANQNAALNGCEHVSFLCDDAANKLTYLSKKRSIDVLVVDPPRSGLDDAMLDCILRSKIKNIIYVSCNPATLGKNLAVLSSRYNVDKIQPIDIFPHTPHVESVVLMSRKNK
>NZ_CP048838.1|WP_002608175.1|1252111_1252930_+|hypothetical-protein
MKWIMDLYREFTSFEGSLFKYSLSFSLLLALAPSLLLIAMLFRFAYLPMDIIMKFLISFMPDMSMDGLDQVFQFFANQNYNITSFIVTMCVSFYLASRSIFSFLLISASHESVEVPKWSIRIKSVVLFVSLVLLLVLSIFIATRLNEFLPIVSAVIMLLLFTMMYRALSFRKRNWSFGIIGAMFSTICILGLAALFVTIVSHFTSYKDVYGPLASLVTLLLAIYLISCIIYLGFCLNLICEEEYGREEALPLKNEKFFILCSELTKRIRSRF
>NZ_CP048838.1|WP_002608174.1|1251572_1252058_+|DUF4358-domain-containing-protein
MKKLLIIGLLLCLMSGCQKNTGTFAQGDKNLSSVFADINEQIADGAFSIPLLKDTALSEREVETLYQLDMTKIESCMVRTAAVQAQLGEIALFKVKKENEGEVKKAIASRKEDLKKQWGAYVPEAADLLYQAKEGRIGQYYYFVLGSDSEKVVNYMQKMDA
>NZ_CP048838.1|WP_002608173.1|1250968_1251358_+|hypothetical-protein
MNSFENNAFFWQKLDTLFLSSKLVIDRPRNTCHYKYSNLVYPVDYGYLNDTTGSDQAPIDVFRGSEKSNLVQSVVISADILKKDCEVKLLVGCTEEDENDILEFLNQTEFQKAVLIRRGNEVPEWAQND
>NZ_CP048838.1|WP_002608172.1|1249928_1250954_+|alpha-hydroxy-acid-oxidizing-protein
MKTWQEVYANAKALCAKCRCCPVCNGLACRGETPGPGGKGSGSAFVRNAEMLKKVFITMDTISNNTEIDTTSEFFGHKVSLPVYAAPISGILQNYGAELDDMSYTRALVDGCRRAGTLAFTGDGMHDEMFKGPMSVVAQHEGFGVPTIKPWSREHMAWRIELAKEGHALAIASDIDASGLTNLRTSITPVGFKNVEELKEITRICGDVPFILKGILSVKGARKALEAGASGIIVSNHGGRVLDDCLSGIEVLEDIVKVVDGRMKVFVDGAFRTGNDVFKALALGADGVLIGRPVSQAVIGDGSDGLVTYLEKIRLELKEAMAMAGCKTIQDITRDCVSVTF
>NZ_CP048838.1|WP_002608182.1|1264692_1265862_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MKFSKRMDLLAEGVFSRLDEEKQKMLASGKAVYDFTIGSPNIAPSKEVMDALITAAQQPESYMYSLHDTKELKETIQAWYRKRYQVELDTETEILSLQGSQEGLAHVALALCDEGDIVLIPAPSYPIFANGPKIAGAELYEMPMLKEYDYLIQFDAIPEEIAEKAKMMIISYPNNPTGATAPDSFYEELIQFAKAHDIIVIHDTAYSNLVFDGEEGKSFLYYAGAKDIGIEFNSFSKTYGMAGARIGICVGNAEIVGILRKLKSNIDYGMFLPIQKAAIAALTQEQSIVKETRETYQRRRNRIVAGAAAAGWHIASCKSTMFLWAQIPEGYGSSEEFALNLLKCSGMLVTPGSSFGAYGEGFVRIALVQSDEVIEQALQALKESRLFLK
>NZ_CP048838.1|WP_002608183.1|1265858_1266458_+|type-1-glutamine-amidotransferase-like-domain-containing-protein
MKTLIAIGGGSFQKQETMSIDTYAISRCGKTQPHVLFIPLASRDDQGYAKRFKQYYRSLDCQVEALRLLHTKLSNEEIYKKFRSQDMIYLGAGDTVFLMKQLKQRKLDLLLKELSQQGIVICGISAGANALFEYGYSNIASDTFELVNGMGMIKGAFCPHYQKEERKSFDMVCRKQNLPAIGCVDQRAYVVTDEKRFFL
>NZ_CP048838.1|WP_002608184.1|1266680_1268015_+|NCS2-family-permease
MLEKLFKLNVKQTSVKTEVIAGITTFLAMAYILGVNPSILHDAGMDRASVFMATAISAGFASIVMGLVANYPVALAAGMGVNALFAYTICGQMGMSWQAALAGVFISGLIFIVISVTGIRKAIINAIPKQLKMAIGAGIGFFIAFVGLKNAGIVAGSASTFVTIGDFADPQVLLALFGILLTIALLVKKVPAAVFVGMVITAIIGIICGAAFGLKGMPALPDKFFEMNFHLNAAGSFVDGFGELFANPLNAFVVIFSFLFVDFFDTAGTLVAVANRIGLVNEKGELENVERALVADAVGTVAGAALGTSTVTSFVESTSGVEVGGRTGLTACTTGILFFVSILFSPIVLSAVTNAVTAPALVVVGILMAQQLKEIEWDNMVYATAGFITVLMMILTYSISNGIAFGFIAYAIAMTAAGKTKEVHITVWVLMVIFLIYFALPQFM
>NZ_CP048838.1|WP_002608185.1|1268137_1269679_+|glutamine-hydrolyzing-GMP-synthase
MADKIIVLDFGSQYNQLIARRIREFGVYSELHPHTMTLEEILALKDVRGIIFSGGPNSVYDEEAFKCDPAIFESGIPVLGICYGMQMTHFMNGGSVKACEAKEYGRTEITIETDSPIFRGLPKKQIVWMSHGDQVDTLADGFVKDAYSDTCTYAATSNIEKNIYTLQFHPEVRHSEYGNEILKNFVFEVCKANNDWSMHSFIDMEIEKIRKTVGTDKVLLGLSGGVDSSVVAALLHKAIGDQLICMFIDHGLLRKGEAESVMETFGREMNINLVKIDAKERFLSKLAGVSDPEKKRKIIGNEFVYTFDEEVKKLTSGEDIKWLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRALGTELGLPDEMVWRQPFPGPGLGIRVLGDITEEKLEIVRDSDLILREEVAKAGLQKEIWQYFTCLTNMRSVGVMGDQRTYDYAVAIRAVTSIDGMTADWAKIPYEVLDVISNRIVNEVKHVNRVVYDITSKPPGTIEFE
>NZ_CP048838.1|WP_002608186.1|1270171_1272133_+|hypothetical-protein
MNDHFFQQFYLHENKDVHLLNPWVSERYHREREKLFYYALQVNKEFVLSSTCMRSNLKNLLMMWRGTDGNETIKFKENDKINAFSSLYQTISILVPVISTTFASVGRFLEYVQKPYELGTLIIDEAGQAQPHLALGAMLRCKKVLVVGDPKQVEPVVTDDLDAIKQLLKNEYTTPYSDKHISVQQFSDKLNPFGTYLNDSSGEKLWVGCPLVVHRRCINPMFDISNRISYDGVMIQQTKEPDQNIVDTFAIPISKWLQCSGKEKNHLRKDHYVPEQGKETLNIIKLAFEKAKGDKPDLYVISPFTSVVEGLKKEIRESDFYKLNKENYNEWMESNIGTVHTFQGKEANEVVLLLGCDQDAKGAVTWVNANIINVAVTRAKYRLCIIGDYRIWKQNQVLKITKGVIDAYTLQYLNQLKEADQTNQNKELITLLMKQLPSSSDYVNEKGDGEEDIIDTYILMKELKKIKFAKNFLTEEEKKIYHLTDEDLNELSYSVKSHLLTGIKINSLYEALFYDNNIPFEDFSFKNIMFCKATELYMRESFISVIQSQFKDAKKKDNNYTIGYMAKKINDNIDTFIRLLNDKYYNGIWWKIYGKKLNDINVLRRTCCHPDEFLLADEQNLKQLLFDEEVFKNLKVGRRIAKNIEKLNIKCVQ
>NZ_CP048838.1|WP_002608187.1|1272870_1273350_-|tRNA-(N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase-TrmO
MTKFEVYSVGSIHSSEEGGTFIQVDENYIPALQALDGFSHLQIIWWFNGYDEDVYRTVLKTKQPYKKAPKEMGIFATRSPIRPNPIALTAVEILHIDYEKGVVQIAYIDANDGSPVLDIKPYTPSLDCIEDPKVPAWCAHWPKSLEKSGSFAWEEEFNF
>NZ_CP048838.1|WP_002608188.1|1273421_1274243_-|MerR-family-transcriptional-regulator
MFRIGEFSKLMQVSVRMLRYYDEVGLLKPAQSDPWTGYRMYSVEQIPVLNRILYLRDCGFTVAEIEGLVLGNDDRMMEALKNKEKEIALAIKAEEQKLHRIDHAKQDFLQGTADMHSNVTIKSIPRCLVVSIRELIPDYYAEEMLWEKLSDFARQHRVDCSPTTFSIYHDEDYKEANVDVELCLPVKKAIRDCDGFQCREVEEEPLMASLMVYGDFSNISAAYQSFAKWLETNRQYEMKGANRQMIHRGPWNEEDAGSYLTELQIPLRMLNKY
>NZ_CP048838.1|WP_002608189.1|1274624_1276097_+|hypothetical-protein
MDYLDKVKAQLKKMSIEEKDAWILTQAKLISNNKQNDFLMALSGTKKIIDMPALDDIDTLCTRIETGDIYLEYVTHYHEFDEDGRYMDDWVIWYNDPFSILPMLERIFTGCHQLGVLEEYQLVYDLLTRIFELKFSVEESENSEDAPEEDYIELSDSKIEEELSYDLDKAATDWIISFMYLTTEQSDKDRAEKLINMLETSICKNLKPRILKDLGGTEKLFVSMQSALEIAIADLETKKTEILKSGNRGRKLFEIKEKLTRSNELLTDIRMRCLERKKEEQMESFLEDRWNDVCEVVEWLSFEKYIDDQPEIDTVLEICEELVQSDEIQYDDWQLRKKVITDIVEHDYYDCLGASDIMDELAEKLCTNDEEYQAYADILYIYRNEEKAAFIYNQHGREDKYITYLENHLGREQKNYNALITYYNLHNQKDDAIRVAQLGLKKCKDDLTDIFIFLLLHTRDNDATWFEKLFASAKRRKNVDMKKIDIVMQR
>NZ_CP048838.1|WP_002608190.1|1276271_1278032_+|DEAD/DEAH-box-helicase-family-protein
MQHEDRIQQLEQENAFLKAELRKRGYFYLSANEKLSTIDKIEIYLSYFRGRPDVYAERYFRKKHQKFGWNPACDRSFQAGCKKGKIKNHCSICPISQFPSLDGVILKHHFTGKLTCEGIGIYPLLTDNTCYLLAMDFDEDNWFDDMLSVYKTALRFEIYPLMERSSSGQGGHLWLFFESPVKALKARKLGSLLIQEAIEGNKNLNFNSFDRMFPNQDYLPQGGFGNLIALPLRHDAYLKGNSAFINDLQQVIDHPIEYLASLPKLQEQQLDQILNSYYKNDYFFDQQQMGLSLDTNMKYSKQMYGLENTMLCIEKKDLNLYTLSVLKRLGSMYNPEYFLKQKLKKTIYRETTPRVLSYYEEDDRYLYLPRGQKYKLQEIFPEAEIQLEAQVTNGQVIDTAFIGELRQNQQEAVNTLMQFDMGIMKAVPGFGKTVMALYMIAQRTVSTLVIVPNKEIQKQWEQRIHEFLTIPPCKSKRDSYIGIYNGSKKKLRGHIDIAVAASLANLENIAVTLKEYGMIIVDECHHAASDTFTRVLRNVNAKYIYGFSATPKRKDGLEKIMHMFCGPIRYETVHFKYRIHTGSNSS
>NZ_CP048838.1|WP_002608191.1|1278040_1279015_+|helicase
MTTMRCLDDNKTYTQYCSDIMNDQNRNYLIVKDVVKEFQNDGKIIILSERKQHLTVLYEMLKHMHIHVYVLTGERKTKERNEIIAKVRNFNNQEKFILLATSKLLGEGFDLPALSTLFLVMPISDESRIEQYTGRIHRNVEGKDMVKVYDYVDAHIPMLEGMFRKRLKQYQKEGYFLQEQNQIVEVSQLMYEGQSYKHVFLDDIKASSSEILIMNAHYELGKIKSYFDVMQEKAHQNVQLYVVLNDEQRQKEMLVRTIEGMGAAILYSNHSAHFVVIDKEIIWYSDMDFLGRAKKDGLSTRLKDPHLVNEIMKIAQDEQLQNIE

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Crispr_ID: NZ_CP048838_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048838_2

1592424-1594426

Orphan

Consensus_repeat	Method
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	PILER-CR
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CRISPRCasFinder
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CRT

29 spacers

The CRISPR arrays of NZ_CP048838_2

>merge|NZ_CP048838|2|1592424-1594426|PILER-CR,CRISPRCasFinder,CRT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGACCGGATGCTGAATATTCCGATTGCATCCATAAATATTTAGATCCACTAGCCTCAGGAGAGGCTAGACTATGTCAGCGCTCTTTCTTCCTTAACTTCTCTCAATTTAGATCCACTAGCCTCAGGAGAGGCTAGACTGGAAAAACTGTAATGCTCTGGCTGCTCTTGCAATTTAGATCCACTAGTCTCAGGAGAGGCTAGACGTGAAAGCATGTTGAATCGAAACAGCACCTCTTGATTTAGAACCACTAGCCTCAGGAGAGGCTAGACTAAAAGATAAAAGGATCTATGTTACTGAGTGTGATATTTAGATCCACTAGTCTCAGGAGAGGCTAGACGCCATGGTCAAAATATCTGTGTTCATACAAGTACCGATATTTAGATCCACTAGCCTCAGGAGAGGCTAGACGGAAAGCAGAAGAAATAAAGCGGCTACGTATTGAATTTAGATCCACTAGCCTCAGGAGAGGCTAGACAAGAGCTGACTGCTAAAGGATATGATTTCCGAAGTAAGATTTAGATCCACTAGCCTCAGGAGAGGCTAGACACGAGTGACGGTCGAATGCATCCAGTGGAAAATGCATTTAGATCCACTAGCCTCAGGAGAGGCTAGACTGTAGCAGATGGATTCCTGGATAAAACACTGGAAATTTAGATCCACTAGCCTCAGGAGAGGCTAGACCGATAATGTGGTCGGTGATAATAATGTGATCAATGGTATTTAGATCCACTAGCCTCAGGAGAGGCTAGACCGGATGTAGCCTGCTTTGTAGATGCCATTGACTTGCCATTTAGATCCACTAGCCTCAGGAGAGGCTAGACCGTTTATATCTGTTCAATCCCTTCCGAATTAAGATTTAGATCCACTAGCCTCAGGAGAGGCTAGACCAGATGAATTGGCGGATCTGACAACATTCTTCAATATTTAGATCCACTAGCCTCAGGAGAGGCTAGACGATGCTCATGCTATACGATCTAGTGTACGACACAATTTAGATCCACTAGCCTCAGGAGAGGCTAGACTAGATAGTCCTAAACGGCATATATGTATGCCGCTACATTTAGATCCACTAGCCTCAGGAGAGGCTAGACGTAAGCAGACGGTGTATAACTGGGGACGTTGGAAATTTAGATCCACTAGCCTCAGGAGAGGCTAGACCAGACCATGTTAAAACAATATGCACAAGAGATATTATTTAGATCCACTAGCCTCAGGAGTGGCTAGACAATAATATATCCAAGGCATTTTATTTCCTTTATTATTTAGATCCACTAGCCTCAGGAGAGGCTAGACGACAAACCAACCCATTGCGCCACACGCCACGATAGGATTTAGATCCACTAGCCTCAGGAGAGGCTAGACGGATTCAGATTTGGAATCTGGATGGGCATTTAATATTTAGATCCACTAGCCTCAGGAGAGGCTAGACCGTGACCGCATTCCGTCTATAAAAAAAGTAATCAGTATTTAGATCCACTAGCCTCAGGAGAGGCTAGACGCCAAGAAACTCACCTCTTGCCACTTTCCTTTCAAATATTTAGATCCACTAGCCTCAGGAGAGGCTAGACAGATGATCTCAACAGGCTCTGGACAAAGGGCAAACATTTAGATCCACTAGCCTCAGGAGAGGCTAGACCTATCTACTTTAACAGGGATAAGCGAAACTAAATTATTTAGATCCACTAGCCTCAGGAGAGGCTAGACAAGGCACTCGGAATAGGAAAGAGTGCCTTCTATATTTAGATCCACTAGCCTCAGGAGAGGCTAGACTTACATATGTATAAATACGGCGCAGTACAGCTAATATTTAGATCCACTAGCCTCAGGAGAGGCTAGACGGTATCAAAGGGTCGAAAGCTGGAACGACGCTGAAATTTAGATCCACTAGCCTCAGGAGAGGCTAGACCCTTTGTATTTGACAAGAAGGTGCCGTCTACACCATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC

>NZ_CP048838|2|2|1592424-1594426|PILER-CR
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGGATGCTGAATATTCCGATTGCATCCATAAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TATGTCAGCGCTCTTTCTTCCTTAACTTCTCTCA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TGGAAAAACTGTAATGCTCTGGCTGCTCTTGCA
ATTTAGATCCACTAGTCTCAGGAGAGGCTAGAC	GTGAAAGCATGTTGAATCGAAACAGCACCTCTTG
ATTTAGAACCACTAGCCTCAGGAGAGGCTAGAC	TAAAAGATAAAAGGATCTATGTTACTGAGTGTGAT
ATTTAGATCCACTAGTCTCAGGAGAGGCTAGAC	GCCATGGTCAAAATATCTGTGTTCATACAAGTACCGAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GGAAAGCAGAAGAAATAAAGCGGCTACGTATTGA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	AAGAGCTGACTGCTAAAGGATATGATTTCCGAAGTAAG
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	ACGAGTGACGGTCGAATGCATCCAGTGGAAAATGC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TGTAGCAGATGGATTCCTGGATAAAACACTGGAA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGATAATGTGGTCGGTGATAATAATGTGATCAATGGT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGGATGTAGCCTGCTTTGTAGATGCCATTGACTTGCC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGTTTATATCTGTTCAATCCCTTCCGAATTAAG
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CAGATGAATTGGCGGATCTGACAACATTCTTCAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GATGCTCATGCTATACGATCTAGTGTACGACACA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TAGATAGTCCTAAACGGCATATATGTATGCCGCTAC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GTAAGCAGACGGTGTATAACTGGGGACGTTGGAA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CAGACCATGTTAAAACAATATGCACAAGAGATATT
ATTTAGATCCACTAGCCTCAGGAGTGGCTAGAC	AATAATATATCCAAGGCATTTTATTTCCTTTATT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GACAAACCAACCCATTGCGCCACACGCCACGATAGG
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GGATTCAGATTTGGAATCTGGATGGGCATTTAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGTGACCGCATTCCGTCTATAAAAAAAGTAATCAGT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GCCAAGAAACTCACCTCTTGCCACTTTCCTTTCAAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	AGATGATCTCAACAGGCTCTGGACAAAGGGCAAAC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CTATCTACTTTAACAGGGATAAGCGAAACTAAATT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	AAGGCACTCGGAATAGGAAAGAGTGCCTTCTAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TTACATATGTATAAATACGGCGCAGTACAGCTAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GGTATCAAAGGGTCGAAAGCTGGAACGACGCTGAA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CCTTTGTATTTGACAAGAAGGTGCCGTCTACACC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC

>NZ_CP048838|2|2|1592424-1594426|CRISPRCasFinder
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGGATGCTGAATATTCCGATTGCATCCATAAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TATGTCAGCGCTCTTTCTTCCTTAACTTCTCTCA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TGGAAAAACTGTAATGCTCTGGCTGCTCTTGCA
ATTTAGATCCACTAGTCTCAGGAGAGGCTAGAC	GTGAAAGCATGTTGAATCGAAACAGCACCTCTTG
ATTTAGAACCACTAGCCTCAGGAGAGGCTAGAC	TAAAAGATAAAAGGATCTATGTTACTGAGTGTGAT
ATTTAGATCCACTAGTCTCAGGAGAGGCTAGAC	GCCATGGTCAAAATATCTGTGTTCATACAAGTACCGAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GGAAAGCAGAAGAAATAAAGCGGCTACGTATTGA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	AAGAGCTGACTGCTAAAGGATATGATTTCCGAAGTAAG
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	ACGAGTGACGGTCGAATGCATCCAGTGGAAAATGC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TGTAGCAGATGGATTCCTGGATAAAACACTGGAA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGATAATGTGGTCGGTGATAATAATGTGATCAATGGT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGGATGTAGCCTGCTTTGTAGATGCCATTGACTTGCC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGTTTATATCTGTTCAATCCCTTCCGAATTAAG
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CAGATGAATTGGCGGATCTGACAACATTCTTCAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GATGCTCATGCTATACGATCTAGTGTACGACACA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TAGATAGTCCTAAACGGCATATATGTATGCCGCTAC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GTAAGCAGACGGTGTATAACTGGGGACGTTGGAA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CAGACCATGTTAAAACAATATGCACAAGAGATATT
ATTTAGATCCACTAGCCTCAGGAGTGGCTAGAC	AATAATATATCCAAGGCATTTTATTTCCTTTATT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GACAAACCAACCCATTGCGCCACACGCCACGATAGG
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GGATTCAGATTTGGAATCTGGATGGGCATTTAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGTGACCGCATTCCGTCTATAAAAAAAGTAATCAGT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GCCAAGAAACTCACCTCTTGCCACTTTCCTTTCAAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	AGATGATCTCAACAGGCTCTGGACAAAGGGCAAAC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CTATCTACTTTAACAGGGATAAGCGAAACTAAATT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	AAGGCACTCGGAATAGGAAAGAGTGCCTTCTAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TTACATATGTATAAATACGGCGCAGTACAGCTAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GGTATCAAAGGGTCGAAAGCTGGAACGACGCTGAA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CCTTTGTATTTGACAAGAAGGTGCCGTCTACACC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC

>NZ_CP048838|2|2|1592424-1594426|CRT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGGATGCTGAATATTCCGATTGCATCCATAAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TATGTCAGCGCTCTTTCTTCCTTAACTTCTCTCA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TGGAAAAACTGTAATGCTCTGGCTGCTCTTGCA
ATTTAGATCCACTAGTCTCAGGAGAGGCTAGAC	GTGAAAGCATGTTGAATCGAAACAGCACCTCTTG
ATTTAGAACCACTAGCCTCAGGAGAGGCTAGAC	TAAAAGATAAAAGGATCTATGTTACTGAGTGTGAT
ATTTAGATCCACTAGTCTCAGGAGAGGCTAGAC	GCCATGGTCAAAATATCTGTGTTCATACAAGTACCGAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GGAAAGCAGAAGAAATAAAGCGGCTACGTATTGA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	AAGAGCTGACTGCTAAAGGATATGATTTCCGAAGTAAG
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	ACGAGTGACGGTCGAATGCATCCAGTGGAAAATGC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TGTAGCAGATGGATTCCTGGATAAAACACTGGAA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGATAATGTGGTCGGTGATAATAATGTGATCAATGGT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGGATGTAGCCTGCTTTGTAGATGCCATTGACTTGCC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGTTTATATCTGTTCAATCCCTTCCGAATTAAG
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CAGATGAATTGGCGGATCTGACAACATTCTTCAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GATGCTCATGCTATACGATCTAGTGTACGACACA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TAGATAGTCCTAAACGGCATATATGTATGCCGCTAC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GTAAGCAGACGGTGTATAACTGGGGACGTTGGAA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CAGACCATGTTAAAACAATATGCACAAGAGATATT
ATTTAGATCCACTAGCCTCAGGAGTGGCTAGAC	AATAATATATCCAAGGCATTTTATTTCCTTTATT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GACAAACCAACCCATTGCGCCACACGCCACGATAGG
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GGATTCAGATTTGGAATCTGGATGGGCATTTAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CGTGACCGCATTCCGTCTATAAAAAAAGTAATCAGT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GCCAAGAAACTCACCTCTTGCCACTTTCCTTTCAAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	AGATGATCTCAACAGGCTCTGGACAAAGGGCAAAC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CTATCTACTTTAACAGGGATAAGCGAAACTAAATT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	AAGGCACTCGGAATAGGAAAGAGTGCCTTCTAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	TTACATATGTATAAATACGGCGCAGTACAGCTAAT
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	GGTATCAAAGGGTCGAAAGCTGGAACGACGCTGAA
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC	CCTTTGTATTTGACAAGAAGGTGCCGTCTACACC
ATTTAGATCCACTAGCCTCAGGAGAGGCTAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048838.1\|WP_002608361.1\|1591643_1592327_+\|sporulation-protein-YunB	unknown	unknown	gnl\|CDD\|378208
NZ_CP048838.1\|WP_002608371.1\|1606426_1608013_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|274495
NZ_CP048838.1\|WP_002608359.1\|1589440_1590838_+\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|273349
NZ_CP048838.1\|WP_002608357.1\|1586228_1588322_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|226477
NZ_CP048838.1\|WP_168388977.1\|1599626_1600730_-\|DUF2974-domain-containing-protein	unknown	unknown	gnl\|CDD\|371412
NZ_CP048838.1\|WP_002608358.1\|1588657_1589194_+\|rubrerythrin-family-protein	unknown	unknown	gnl\|CDD\|153100
NZ_CP048838.1\|WP_002608355.1\|1581938_1583606_-\|Na/Pi-cotransporter-family-protein	unknown	unknown	gnl\|CDD\|224202
NZ_CP048838.1\|WP_002608366.1\|1601978_1603034_+\|alanine--glyoxylate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223153
NZ_CP048838.1\|WP_002608356.1\|1584330_1586004_-\|Na/Pi-cotransporter-family-protein	unknown	unknown	gnl\|CDD\|224202
NZ_CP048838.1\|WP_002608362.1\|1594685_1597064_-\|ribonucleoside-triphosphate-reductase	unknown	unknown	gnl\|CDD\|236212
NZ_CP048838.1\|WP_002608364.1\|1598453_1599524_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|277331
NZ_CP048838.1\|WP_002608363.1\|1597082_1598219_-\|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein	unknown	unknown	gnl\|CDD\|274164
NZ_CP048838.1\|WP_002608350.1\|1576984_1577716_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349976
NZ_CP048838.1\|WP_002608369.1\|1604686_1605664_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270262
NZ_CP048838.1\|WP_002608370.1\|1605651_1606437_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP048838.1\|WP_002608360.1\|1590850_1591528_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NZ_CP048838.1\|WP_002608367.1\|1603030_1603744_+\|phosphocholine-cytidylyltransferase-family-protein	unknown	unknown	gnl\|CDD\|133014
NZ_CP048838.1\|WP_002608352.1\|1579557_1580760_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP048838.1\|WP_002608351.1\|1577838_1579488_+\|NAD(+)-synthase	unknown	unknown	gnl\|CDD\|237577
NZ_CP048838.1\|WP_002608368.1\|1603902_1604502_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048838.1\|WP_002608361.1\|1591643_1592327_+\|sporulation-protein-YunB	gnl\|CDD\|378208	pfam09560, Spore_YunB, Sporulation protein YunB (Spo_YunB). Spo_YunB is the sporulation protein YunB. In Bacillus subtilis its expression is controlled by sigmaE.The gene YunB seems to code for a protein involved, at least indirectly, in the pathway leading to the activation of sigmaK. Inactivation of YunB delays sigmaK activation and results in reduced sporulation efficiency.	2.92916e-28
NZ_CP048838.1\|WP_002608371.1\|1606426_1608013_+\|ABC-transporter-permease-subunit	gnl\|CDD\|274495	TIGR03262, PhnU2, putative 2-aminoethylphosphonate ABC transporter, permease protein. [Transport and binding proteins, Amino acids, peptides and amines].	3.42217e-112
NZ_CP048838.1\|WP_002608359.1\|1589440_1590838_+\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	1.22333e-91
NZ_CP048838.1\|WP_002608357.1\|1586228_1588322_-\|glutamine-synthetase	gnl\|CDD\|226477	COG3968, COG3968, Uncharacterized protein related to glutamine synthetase [General function prediction only].	0
NZ_CP048838.1\|WP_168388977.1\|1599626_1600730_-\|DUF2974-domain-containing-protein	gnl\|CDD\|371412	pfam11187, DUF2974, Protein of unknown function (DUF2974). This bacterial family of proteins has no known function.	1.22809e-101
NZ_CP048838.1\|WP_002608358.1\|1588657_1589194_+\|rubrerythrin-family-protein	gnl\|CDD\|153100	cd01041, Rubrerythrin, Rubrerythrin, ferritin-like diiron-binding domain. Rubrerythrin domain is a nonheme iron binding domain found in many air-sensitive bacteria and archaea and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The homodimeric rubrerythrin protein contains a binuclear metal center located within a four helix bundle. Many, but not all, rubrerythrin proteins have a second domain with a rubredoxin-like hexacoordinated iron center. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system but its function is still poorly understood.	2.3775e-56
NZ_CP048838.1\|WP_002608355.1\|1581938_1583606_-\|Na/Pi-cotransporter-family-protein	gnl\|CDD\|224202	COG1283, NptA, Na+/phosphate symporter [Inorganic ion transport and metabolism].	2.62835e-121
NZ_CP048838.1\|WP_002608366.1\|1601978_1603034_+\|alanine--glyoxylate-aminotransferase-family-protein	gnl\|CDD\|223153	COG0075, COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism].	1.20018e-76
NZ_CP048838.1\|WP_002608356.1\|1584330_1586004_-\|Na/Pi-cotransporter-family-protein	gnl\|CDD\|224202	COG1283, NptA, Na+/phosphate symporter [Inorganic ion transport and metabolism].	2.18196e-117
NZ_CP048838.1\|WP_002608362.1\|1594685_1597064_-\|ribonucleoside-triphosphate-reductase	gnl\|CDD\|236212	PRK08270, PRK08270, ribonucleoside triphosphate reductase.	0
NZ_CP048838.1\|WP_002608364.1\|1598453_1599524_+\|hypothetical-protein	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.07081e-39
NZ_CP048838.1\|WP_002608363.1\|1597082_1598219_-\|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein	gnl\|CDD\|274164	TIGR02495, RADICAL-ACTIVATING_ENZYME, anaerobic ribonucleoside-triphosphate reductase activating protein. This enzyme is a member of the radical-SAM family (pfam04055). It is often gene clustered with the class III (anaerobic) ribonucleotide triphosphate reductase (NrdD, TIGR02487) and presumably fulfills the identical function as NrdG, which utilizes S-adenosyl methionine, an iron-sulfur cluster and a reductant (dihydroflavodoxin) to produce a glycine-centered radical in NrdD. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism, Protein fate, Protein modification and repair].	5.37657e-64
NZ_CP048838.1\|WP_002608350.1\|1576984_1577716_-\|RNA-methyltransferase	gnl\|CDD\|349976	cd18103, SpoU-like_RlmB, SAM-dependent rRNA methylase related to RlmB. 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	1.17538e-51
NZ_CP048838.1\|WP_002608369.1\|1604686_1605664_+\|extracellular-solute-binding-protein	gnl\|CDD\|270262	cd13544, PBP2_Fbp_like_1, Substrate binding domain of a putative ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The substrate domain of this group shows a high homology to the periplasmic component of ferric iron transporter (Fbp), but its biochemical characterization has not been performed. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	9.09947e-59
NZ_CP048838.1\|WP_002608370.1\|1605651_1606437_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	6.79858e-116
NZ_CP048838.1\|WP_002608360.1\|1590850_1591528_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	4.16292e-50
NZ_CP048838.1\|WP_002608367.1\|1603030_1603744_+\|phosphocholine-cytidylyltransferase-family-protein	gnl\|CDD\|133014	cd02523, PC_cytidylyltransferase, Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline. This family contains proteins similar to prokaryotic phosphocholine (P-cho) cytidylyltransferases. Phosphocholine (PC) cytidylyltransferases catalyze the transfer of a cytidine monophosphate from CTP to phosphocholine to form CDP-choline. PC is the most abundant phospholipid in eukaryotic membranes and it is also important in prokaryotic membranes. For pathogenic prokaryotes, the cell surface PC facilitates the interaction with host surface and induces attachment and invasion. In addition cell wall PC serves as scaffold for a group of choline-binding proteins that are secreted from the cells. Phosphocholine (PC) cytidylyltransferase is a key enzyme in the prokaryotic choline metabolism pathway. It has been hypothesized to consist of a choline transport system, a choline kinase, CTP:phosphocholine cytidylyltransferase, and a choline phosphotransferase that transfers P-Cho from CDP-Cho to either lipoteichoic acid or lipopolysaccharide.	1.4996e-52
NZ_CP048838.1\|WP_002608352.1\|1579557_1580760_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	2.38072e-43
NZ_CP048838.1\|WP_002608351.1\|1577838_1579488_+\|NAD(+)-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	4.6308e-55

>NZ_CP048838.1|WP_002608361.1|1591643_1592327_+|sporulation-protein-YunB
MRKVKSRKYKKQKLILLLVAIVLGFGCVVRSFNTYMEPQLQAIAKQHTGFAINNIVKEVLADIEYDTDALFKINRTKNGDITSIEYDSYKLNQLLYSALNTIDKSLLAAQDGKKDPTTKDVFYEDGVLYEVPAGYLSHIFFLYDKGPKIRVRMRMLNDVTGEIKTESKPYGINNTMIKISLVVKVNAQVITFLSTSELETKTEIPLVVQIVNGQVPDFTPYSSSSGK
>NZ_CP048838.1|WP_002608360.1|1590850_1591528_+|TrkA-family-potassium-uptake-protein
MKKISNRQYVVLGLGIFGSTVAKTLSSYNCEVIALDNDEKCVDRMADIVTQSMMCDITDINQLREAGVQDCDIAIVSMGSHLEESVMGIINLKELGVPYIVAKAKNKRYMQIFTELGANKVVRPEKEMGEQVAKGVLGKNIIDVVDLDKEYSIVEIPTPPQWVGKSLIELDLRRRFGINVVGIRSYLQEHLNVCPDAEYKIQKEDHLVVIADCKTLDRFDVLDQL
>NZ_CP048838.1|WP_002608359.1|1589440_1590838_+|TrkH-family-potassium-uptake-protein
MTNFIHSVLGFKKLSPAQKIASSFLLVILSGTLLLMLPISNKNFQFLNWLDALFTATSATCVTGLSVFTVADQLNWFGQLILLLLIQVGGLGLMTFMAVFILIVKNRLSMNEKIAMKEMLNQERVVNMRKFLLDILYYTLFFEAVGAILISFRMIPRFGLVDGSFKAVFLAVSAFCNAGFDTLGSVSLQEYVHDPLMCLTIMALIVLGGLGFAVWFDIRDKVGPLLHRRITFKKFRHSLSLHTKIVLSVSLFLIIIPGLLIMLVEFTNSRTLGDFNIFEKLMTAMFESIALRTAGFTTINYAGLKPATDLLMMVVMFIGGSPGGTAGGIKTTTIAVLVIYIISSLKGREHTVVLHRKIGRGIIIRAMGIFFINLVVLFTGIFLLNIVEQKPFLSLSFEAVSAMATVGSSLGITTSLGVGGKLIIIFLMYVGRIGISTLILSLTRNKPNRNSANKVSFPNGNIIVG
>NZ_CP048838.1|WP_002608358.1|1588657_1589194_+|rubrerythrin-family-protein
MNLKGTKTEKNLNEAFAGESMARNKYTYYASKAKKDGYVQISNIFEQTANNEKEHAKLWFKLLHDGMPDTVTNLKDAAAGENFEWTDMYARMAKEAREEGFDDIADTMEGVLAIEKTHEQRYVALLNNIEDGTVFEKAEETLWECLNCGHLHTGKTAPEVCPVCNHPRSYFEVRKENY
>NZ_CP048838.1|WP_002608357.1|1586228_1588322_-|glutamine-synthetase
MAEKHPFDDFGINLFSECVMKECLPHPIYKKWKTATRKEDALDRPTADAIAHAMKTWAMDRGATHFTHWFQPLTGSTAEKHDSFIEPGDHDQPISRFSGKSLIKGEGDASSFPSGGLRATFEARGYTYWDCTSPAFLRDNVLCIPTIFVSYNGETLDKKAPLLKSAEAISKQATRIVNLFKDKDIKHVNAMVGLEQEYFLIDKRMYLERKDLVHTGRTLFGSMPPKSMDIRGHYFGSIPSRVQAFMTEVDEELWKLGIYAKTEHNEVAPCQFEIAPLFIDANVAVDQNLIIMDVLKKKADKHGMACLLHEKPFQGVNGSGKHNNWSLVTDDGQNLLEPGDRPHENIRFLLFVCAIIEAVDTYPELLRMAASCYGNDYRLGADEAPPAVVSICMGDELEIILEKLRNGEHEIKPDVETQPYAIANLSYVPKDTSDRNRTSPFAFTGNKFEFRMVGSSRSASTTNIILNSIVADSLRSIADTLQQYKYIDDIRKKSLDICRDILRKHSRILFSKDGYSEEWLQEAQERGLPNIKHYVDSIYSMLDDKAVEMFERNKVYDRLELEARVDILTEEYRKSVKAEVLTLLDISKKDILPALVREIKFYTDAQNSLGTENSYYQRKIKHLCDLLATFDERYHDLKKHMIERQQYPDNMEKAQYLNQVIVPKMEELRAVIDAIEEAVSSDNYPFPTYDDMFISMQ
>NZ_CP048838.1|WP_002608356.1|1584330_1586004_-|Na/Pi-cotransporter-family-protein
MTIQNVLSLLGGLALFLYGMHMMSVGLETAAGDRMKAILEKLTSNRLLGVAVGAGITAVIQSSSATTVMVVGFVNSGLMTLNQAVWIIMGANIGTTITGQLIALDASRIAPLVAIIGVVMVTFLKGKRINSIGDILAGLGILFIGMDMMSNSMTPLQDSPVFLNAMTSISNPLLAIALGAGFTALIQSSSASVGILQALALSGLIPLSSSIYIIFGQNIGTCITAVLASLSANRNAKRTTIIHLSFNIIGTMLFFCFIHIFPFVDWMCEITANPAAQIANTHTIFNIVTTLILLPFGNRLAHLAQLLMPIRKEEYQRDEANLPLAFVDVNNIGSVPIAISSLRKEALAMLKMAQTNLIEALHGVCQEACSIQDIEKREKRIDSINYQISDYMTSVSTLPMNPTASNTINALFKCYADIERIGDHAINILQYTKNEKERLQDVGVIREELKQLEELLDKSFQLLYTNRLESQDESLLKIERIEARIDELTAEFRNRQIERMVHKQIHARDCVIYSEIMTDIERVSDHIINIIEECRRCSFTLNDEELKDMPLIQECAA
>NZ_CP048838.1|WP_002608355.1|1581938_1583606_-|Na/Pi-cotransporter-family-protein
MTFDSILKLFGGLALFLYGMHMMSSGLEGAAGDRMKTILERLTSNRFLGIIVGAAITAVIQSSSATTVMVVGFVNSQLMTLNQAVWIIMGANIGTTITGQLIALDASKIAPLVAIFGVVLVTFLKGKKVNAFGEIFAGLGILFIGMDMMKDAMVPLQQSEAFIHAMTTISNPVLAILLGAGFTALIQSSSASVGILQALAVSGLIPLSSAIYIIFGQNIGTCITSVLASLGANRNAKRATIIHLSFNIIGTIVFMAFAALVPFVSWMESVTSNPAAQIANTHTIFNIATTLLLIPFGSRLAKLAQVILPVKQEEIEDAGYNIPLTFVDEDNIGSVPIAISSLRKEAMAMLQLAETNLAESMDALCGNAFSLEKIKKREKRIDYINYEITNYMTLVSSLKMNESDSTTCNALYKCFSDIERIGDHAINIIQYSTDEDNKLSSSKYIEDELHQLASLLSKSFSLLSTYSLDSQDECFEKIERIEDRIDELTASYRQAQIERLMEKKVNVLDCVIYSEILTDVERVSDHIMNIIQEAKRCNFTLSDEAIQSDPALSAA
>NZ_CP048838.1|WP_002608352.1|1579557_1580760_+|AI-2E-family-transporter
MKFRLTEDMRKKIWLYVIVIAIGISIYFAFDKIDFIIRSLRRVCSLTTPFILGFAIAFLLNKPMELIEVKLLGRLRMKPQHKRSIAAVLAVLLGIIIVCAFLALLLPQLFDSIFSLVKAFPGYVEDFQKFALDFVEKYAIDTQQVTNYITDTDFFEKLTGFVTDALPQMAKATYAFGSTLLNILLSIMAGLYMLIDKERLSGYAKKINYALFPKEISEYLHRMVLASGDIFNNFIVGKAIDSLIIGILCYIGSLIFQFPYALLLSVIVGVTNMIPVFGPFIGAVPGIVILFIIHPITALYFALFVFALQQFDGNILGPLILGDKLGLPSIGILFSVCVGGGLFGIIGMFIGVPCFAVIYMAVKEFVNYRLKKKEIDLESISREMKKEALEIEERMEQLEE
>NZ_CP048838.1|WP_002608351.1|1577838_1579488_+|NAD(+)-synthase
MKVAVVTMHVKQGKCEENVSYMKQMIQKAREEQADMIVFPQNAVSGYLLGDQWLDDDWCRYVDSFNEALLAESEDIAIVWGNIRYRNRRRFNAAFFAYRKQTHMRVKRNTPYMDDARYFEENPINSAIEFKGHVFALNFGREVQLTDININLDAAMYELDQTYSLKGNVIYANALGMQNSGKDVVVMAGGSGVRMQKKTIYQAAWFHEEMQIVDLAETREVESTQPQLLDALLLGIRDFDAQIFNRAIPWIVGMSGGLDSSVTAALLVAALGPKRVYGYNIATRHNSTTTISNAAAEAKALGIAYQEGNMETLVQASVELFHKEYGYAVEAMPSLVMENVQARSRGYLLSGFAGILGGVVVNNGNKVETALGYCTLYGDSIGALSLIGDLTKVQLFDLSKALNAHFGKEVVPLNLLPCVHEHGVDWTMPPSAELKDAQFDPMKWFYHDYLIEHLGTDLSLRSFMESYADGSIWKQDIARWMKYYHLDDPDAFLKDLEWLLTTRAKNAFKRLQLPPLLSVHKRTLANTREAQMREDRYVFEELKQRILND
>NZ_CP048838.1|WP_002608350.1|1576984_1577716_-|RNA-methyltransferase
MEQYIVEGNISVKAVLLAQKRDIIKIMVDEKKKDRDTAFILRQAAQRNIPIEQNSREAIDELAQGKTHGGLLALCGERSFQTLQAVAEKDSVFLALIEGVEDPFNFGYILRTLYAAGCDGVIIPPRNWTTAAGVVTKASAGASEYLNLIVATDMEALLHEMKQADIQLICAQRKDAISLYDYAFPLKLCLAIGGEMRGLSKHVQNHSDQNLFIPYRQDFRNAMTAAASTAIFAFELVRQKTAD
>NZ_CP048838.1|WP_002608362.1|1594685_1597064_-|ribonucleoside-triphosphate-reductase
MYQVIKRDGKISEFDIAKISNAIQKAFDAVERQYHPSIIDMLALRVTSDFEPKIRHDRIQVEDIQDSVESILIQSGYGDVAKCYILYRKQREKIRNMKSTILDYKELVDSYVKATDWRVKENSTVTYSVGGLILNNSGAITANYWLSEIYDEEIGNAHKSGDMHIHDLSMLTGYCAGWSLKQLIQEGLGGVGGKITSKPASHLATLCNQMVNFLGIMQNEWAGAQAFSSFDTYLAPFVKADNLNYDQVKKCVESFIYGVNTPSRWGTQAPFSNITLDWTVPADLAELNCIIGGKEVDFKYKDCKKEMDMVNKAFIEIMIEGDANGRGFQYPIPTYSITRDFDWSETENNKLLFEMTAKYGTPYFSNYVNSDMEPSDVRSMCCRLRLDLRELRKKSGGYFGSGESTGSVGVVTINMPRIAYLSTDKEDFYKRLDHLMDIAARSLKVKRTVISKLLEEGLYPYTKRYLGTFANHFSTLGLIGMNEVALNAKWLGMDLTQKEAQKFTKEVLNHMRERLVIYQEEYGDLYNLEATPAESTTYRLAKHDKERYPDIITATEEGNTPYYTNSSHLPVGYTEDIFEALDVQDELQTLYTSGTVFHAFLGEKLPDWKAAAALVRKIAENYRLPYYTLSPTYSICRNHGYINGEHYTCPQCGGATEVWSRITGYYRPVQNWNEGKSQEFKERKVYDIGHSVLKGKDALPHVEKEADTVKAVNEEGVFLFTTKTCPNCKIADTWLKSAGISYEKVDAEEQAELTKKFSIMQAPTLVVCRDGSCETYSNASNIRKYIDMMQKA
>NZ_CP048838.1|WP_002608363.1|1597082_1598219_-|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein
MDNSNYLYLNTSILYRCGQKYYDKKLSGHDINAAQILFLILIYEQEGLNMQQLAQKGCFDKGTITKSISRLEELGYVTTQSSPQDKRIRLLYTTDKTKDIIRDIYMIRQQWWELLSKDIGAQELQQFEATLSRLSENARRYEQQEEAGIKLFGIQKLTLLDYPQKMASTIFTGGCNFRCPFCQNSDLVFLPENMPELQEEDVLSFLEKRKGILDGVCISGGEPLLNPELAGFLKKIKDMGYAVKLDTNGSSPDQLKYLVEEGLVNYVAMDIKNAPQKYSETAGIRNLDLSGIQESITYLKEGHVAYEFRTTIVKELHTAQDIQDMADWLQGAAAWYLQNFEDSDRVIQKGLHAWDEETLQQFQKLAKAKVPNTELRGI
>NZ_CP048838.1|WP_002608364.1|1598453_1599524_+|hypothetical-protein
MRMQLFLLLCLLLLILMQLFFWHMIKKMYKKKQIRYALLILSLLGSVFLIYRFTPFFAMYKDAMPMRGALVLVLNSVYVAQMTGFCLLALLHKLYCRRYSKEFHSRLYVLASVVMLLFSVYGIGCAARVKVHQEIVELKGVKQEQKLLYITDLHAGTTLSSPYNTIKRLAGKCDIVLLGGDLFDESTSQKDMEALCTMLSDLHKDVYYAGGNHELLQKRRREYEAMLRSAGVHILQDESAVVNGVRIIGRRDRGEERRSWSSLTKEYQGNEPVILLEHRPESVEESLDAQLLQLSGHTHNGQIFPNTVLTRIPYPRAYGSYDVGYRMLVSSGAGTWGFPMRVASHNEILFVTIRPK
>NZ_CP048838.1|WP_168388977.1|1599626_1600730_-|DUF2974-domain-containing-protein
MSNLFDYLTWRNDLTFSKVPCCAVDTLICSCLSYLRLQPVFDKQDMLYVKRASEIIRAINPEEIHFRVKEDLQLLHKMAEGNRYGNVILCGYVDHLDPSMEKQFSALTCLLEDDVMLITYRGTDNTLVGWKEDFNMTFLDTIPSQKEAVQYWEAMAIAYPDRRIILCGHSKGGNLAVYAAAFCSFAIQNRIQRVYNHDGPGFAAETLQAAGYRSIAQRIETFVPQSSVVGMLMEHEEHYTVISSTQISLWQHDPYSWEVLGPDFVRMDALDRQSIVLDSTIKHWISELDRSQREAFTDAVFQILSNTNAASFKEMNENRMHSTALILKALNRTDKQTKKMLSDIILKLLSSAKSAIETNLENGKPTD
>NZ_CP048838.1|WP_002608366.1|1601978_1603034_+|alanine--glyoxylate-aminotransferase-family-protein
MKLFTVGPVEMYPETLQVSGTQLPYFRNDEFSSIMKENEQQLLTLCGCRKGRALFLCGSGSAAMEAVVACSFRRQDKVLILRGGSFGERFVQLCRIYGIPYDELCLQELEALRKEHLDAFFQNEYCALLVNLHETSTGQLYDIQLLSAFTKAKNMYLIVDAISSFMADPLDMDQMGIDVLILSSQKALALSCGLSMVVLQESFYRDMVEPKDDICLYLSLKEHARNMERGQTPNTPAVGILMELHERLQHLQGDGFVLEQQRIATRAAYFRSRVQKLGIQLPHFPLSNALTPLLFDGDAQKVYQFLKKNYAITLTPSGGAMRERMLRVGHLGNLKLCDYDALCDGLREYGK
>NZ_CP048838.1|WP_002608367.1|1603030_1603744_+|phosphocholine-cytidylyltransferase-family-protein
MKAILMAAGMGTRIATKTNEPKCLLDIGNGPLIRHTVELLLNNHMEVCICLGFKGYLIREALRDYPITFYENPFYRVTNSIASLWFSREQLDEAQDLLLANADVFWQQDILDLLLADQRGIVLLADSSRRLSGDYFFHCENGILTDYGKDMPEAERTSEYVGIARIQKQEIACFRKQLELLVQEGDYQLWWENTLYSMIPQKQIPVQDIAGHYWSEIDVLQDYENILDYVHRHPQCL
>NZ_CP048838.1|WP_002608368.1|1603902_1604502_-|hypothetical-protein
MKHKLPILLVICMLLQLGGVHAAEKEERLLLMSDDLAWLIDVRIKEDDSLQIGFLPADLLVPIACAQGYAAPLSNVKMETNRECITESVGNFLHVDYDHSIYLHMKTFSRDVGLTLPDTGLKTSGELVDFMHKASDKLEMSMLFHYKNYITSDLSAMDYIRYYRRLHGKKLSITYAYMNYMDMEDASIPMDNQLHVRKK
>NZ_CP048838.1|WP_002608369.1|1604686_1605664_+|extracellular-solute-binding-protein
MKKLILAMIVITMALLVSISNEQHTIIVYSSMEQFRGEELQKQLNEKFPDLHVMVMYVSTAKAAAKISVEQEQSDADIVVGLETSYMEKIKDQLADIKGKSRLQYLNGLAPEDHGNAYVTWERQAGALIINTDVLKKHKLSEPKTYEDLLDRKYYNLIAMPDPKSSGTGYFFFKNLVNTMGEEKALAYIDKLEFNVKQFTESGSGPIKLLIQGEIGIGLGLTFQAVNQINTGSPFKIIYPKEGSPYSLTGTGLMKRHADDPDVQRVFDFIINDFLLYDKEHFSPEVILQNQKNTIQNYPTHIPYADMSGIEDIHEKERLLDLWKY
>NZ_CP048838.1|WP_002608370.1|1605651_1606437_+|ABC-transporter-ATP-binding-protein
MEVLEKEKLIVRDLYKNFDGKDVLKTISFTVHEGEFLSVLGPSGCGKTTLLRILIGLEQQTKGQILMDGEDISHLKPSERNMGIIFQNYALFPNMTVLENVEYALKLRPGKKAESRKIALQTLDAIGMSDQTEKRPSQLSGGQQQRVAIARTLALNPKIILLDEPISALDVSMREVMKKELKDIQRRFHSTMIFITHEQEEAFYLSDRIMVMSEGNIEQIDTPQTIYHHPANRYIQSFVNAHLDGKLESLCKCTGKQVYEQ
>NZ_CP048838.1|WP_002608371.1|1606426_1608013_+|ABC-transporter-permease-subunit
MSNKRYQVSRVLVALFLFFFVICPLITLLIHIDMKDIQKVLTSPQFQPMVINSLCTTILATLLSVSLAFVLAWFMNRSHIRHRSVFTMLFTLPMLIPSISHGMGLVLLFGDNGIISNLLHMRFFLYGYVGIILGSILYSFPVAFLMLNDTFQYEDYTTYEAASVLGLSKRQQFFTITLPNIKGPLISVIFSVFTMIFTDYGVPLVVGGKSITLPVYMYREVIGLLDFSKGAIIGILLLIPAVIAFVLDLRNENKSSSSTVTRSYQIAPNAKRDRIAYIVCIATVVFLSLPLITFAVLSFVRHYPTDLSLTLDNITQAMDLGVRMYLKNSLAIAMLTSMIGVCLTYLTAFMTARNASQLSSRVLHLVSMISLAIPGVVLGLSYVLFYKGSFLYGGIAILVLVNITHFFANPYLMAYNSLQQFHSNLEDISTAMGISRFRMLKDVYIPCTKGTIVEMFSYLFVNSMVTISAVSFLANFRNMPLSLLIPQFDSQSLIEATAFISVVILLVNLIVKLLVYVVKRKLIKDHEA

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Crispr_ID: NZ_CP048838_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048838_3

4316301-4316470

TypeV

Consensus_repeat	Method
ATAGATTTAGATCCACTAGCCTCAGG-GAGGCTAGAC	PILER-CR
GTCTAGCCTCCCTGAGGCTAGTGGATCTAAAT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP048838_3

>merge|NZ_CP048838|3|4316301-4316470|PILER-CR,CRISPRCasFinder
GTCTAGCCTCCCTGAGGCTAGTGGATCTAAATGCTATAATCTTGACAAGGGAAGTAGCACGGCTTGTCTAGCCTCCCTGAGGCTAGTGGATCTAAATCTATAGTGCTGCTGGCTCCTGTTATGATTTCCGGGAGGTCTACCCTCCCTGAGGCTAGTGGATCTAAATTTAT

>NZ_CP048838|3|3|4316301-4316470|PILER-CR
GTCTAGCCTCCCTGAGGCTAGTGGATCTAAATGCTAT	AATCTTGACAAGGGAAGTAGCACGGCTTGTCTA
GCCTCCCTGAGGCTAGTGGATCTAAATCTATAGTGCT	GCTGGCTCCTGTTATGATTTCCGGGAGGTCTA
CCCTCCCTGAGGCTAGTGGATCTAAATTTAT

>NZ_CP048838|3|3|4316301-4316466|CRISPRCasFinder
GTCTAGCCTCCCTGAGGCTAGTGGATCTAAAT	GCTATAATCTTGACAAGGGAAGTAGCACGGCTT
GTCTAGCCTCCCTGAGGCTAGTGGATCTAAAT	CTATAGTGCTGCTGGCTCCTGTTATGATTTCCGGGAG
GTCTACCCTCCCTGAGGCTAGTGGATCTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048838.1\|WP_002606211.1\|4312335_4313229_-\|decarboxylating-6-phosphogluconate-dehydrogenase	unknown	unknown	gnl\|CDD\|236582
NZ_CP048838.1\|WP_002606225.1\|4327894_4329256_-\|Sapep-family-Mn(2+)-dependent-dipeptidase	unknown	unknown	gnl\|CDD\|349884
NZ_CP048838.1\|WP_002606210.1\|4311488_4312310_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|377077
NZ_CP048838.1\|WP_002606207.1\|4309645_4310077_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|225446
NZ_CP048838.1\|WP_168389054.1\|4308034_4308682_-\|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase	unknown	unknown	gnl\|CDD\|180618
NZ_CP048838.1\|WP_002606206.1\|4308716_4309646_-\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240649
NZ_CP048838.1\|WP_002606224.1\|4326177_4327791_-\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|182245
NZ_CP048838.1\|WP_002606214.1\|4316577_4318452_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	unknown	unknown	gnl\|CDD\|235362
NZ_CP048838.1\|WP_002606227.1\|4331160_4331649_-\|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|376324
NZ_CP048838.1\|WP_002606209.1\|4310598_4311459_-\|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID	unknown	unknown	gnl\|CDD\|377079
NZ_CP048838.1\|WP_002606203.1\|4306427_4307369_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048838.1\|WP_002606226.1\|4329368_4330904_+\|transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP048838.1\|WP_002606223.1\|4325615_4326155_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048838.1\|WP_002606218.1\|4320764_4321625_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|236467
NZ_CP048838.1\|WP_002606219.1\|4321624_4322698_-\|peptide-chain-release-factor-1	unknown	unknown	gnl\|CDD\|234801
NZ_CP048838.1\|WP_002606208.1\|4310073_4310580_-\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|377139
NZ_CP048838.1\|WP_002606228.1\|4331877_4332594_+\|pentose-5-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|238244
NZ_CP048838.1\|WP_002606204.1\|4307379_4308048_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223710
NZ_CP048838.1\|WP_002606212.1\|4313642_4314488_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP048838.1\|WP_002606215.1\|4318465_4318801_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179460

Protein	Function_ID	Function_description	E-value
NZ_CP048838.1\|WP_002606211.1\|4312335_4313229_-\|decarboxylating-6-phosphogluconate-dehydrogenase	gnl\|CDD\|236582	PRK09599, PRK09599, NADP-dependent phosphogluconate dehydrogenase.	4.92485e-167
NZ_CP048838.1\|WP_002606225.1\|4327894_4329256_-\|Sapep-family-Mn(2+)-dependent-dipeptidase	gnl\|CDD\|349884	cd03888, M20_PepV, M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides. Peptidase M20 family, Peptidase V (Xaa-His dipeptidase; PepV g.p. (Lactobacillus lactis); X-His dipeptidase; beta-Ala-His dipeptidase; carnosinase) subfamily. The PepV group of proteins is widely distributed in lactic acid bacteria. PepV, along with PepT, functions at the end of the proteolytic processing system. PepV is a monomeric metalloenzyme that preferentially degrades hydrophobic dipeptides. The Streptococcus gordonii PepV gene is homologous to the PepV gene family from Lactobacillus and Lactococcus spp. PepV recognizes and fixes the dipeptide backbone, while the side chains are not specifically probed and can vary, rendering it a nonspecific dipeptidase. It has been shown that Lactococcus lactis subspecies lactis (L9) PepV does not hydrolyze dipeptides containing Pro or D-amino acids at the C-terminus, while PepV from Lactobaccilus has been shown to have L-carnosine hydrolyzing activity. The mammalian PepV also acts on anserine and homocarnosine (but not on homoanserine), and to a lesser extent on some other aminoacyl-L-histidine dipeptides. Also included is the Staphylococcus aureus metallopeptidase, Sapep, a Mn(2+)-dependent dipeptidase where large interdomain movements could potentially regulate the activity of this enzyme.	4.51512e-151
NZ_CP048838.1\|WP_002606210.1\|4311488_4312310_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|377077	pfam03609, EII-Sor, PTS system sorbose-specific iic component.	7.75548e-58
NZ_CP048838.1\|WP_002606207.1\|4309645_4310077_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|225446	COG2893, ManX, Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism].	8.58376e-31
NZ_CP048838.1\|WP_168389054.1\|4308034_4308682_-\|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase	gnl\|CDD\|180618	PRK06552, PRK06552, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	6.28771e-95
NZ_CP048838.1\|WP_002606206.1\|4308716_4309646_-\|phosphoglycerate-dehydrogenase	gnl\|CDD\|240649	cd12172, PGDH_like_2, Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.	6.80639e-141
NZ_CP048838.1\|WP_002606224.1\|4326177_4327791_-\|PTS-transporter-subunit-EIIC	gnl\|CDD\|182245	PRK10110, PRK10110, PTS maltose transporter subunit IICB.	1.43866e-94
NZ_CP048838.1\|WP_002606214.1\|4316577_4318452_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	gnl\|CDD\|235362	PRK05192, PRK05192, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG.	0
NZ_CP048838.1\|WP_002606227.1\|4331160_4331649_-\|PTS-glucose-transporter-subunit-IIA	gnl\|CDD\|376324	pfam00358, PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1.	1.66142e-61
NZ_CP048838.1\|WP_002606209.1\|4310598_4311459_-\|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID	gnl\|CDD\|377079	pfam03613, EIID-AGA, PTS system mannose/fructose/sorbose family IID component.	1.14644e-97
NZ_CP048838.1\|WP_002606226.1\|4329368_4330904_+\|transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	6.74201e-34
NZ_CP048838.1\|WP_002606218.1\|4320764_4321625_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl\|CDD\|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	1.43415e-95
NZ_CP048838.1\|WP_002606219.1\|4321624_4322698_-\|peptide-chain-release-factor-1	gnl\|CDD\|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0
NZ_CP048838.1\|WP_002606208.1\|4310073_4310580_-\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|377139	pfam03830, PTSIIB_sorb, PTS system sorbose subfamily IIB component.	1.18584e-51
NZ_CP048838.1\|WP_002606228.1\|4331877_4332594_+\|pentose-5-phosphate-3-epimerase	gnl\|CDD\|238244	cd00429, RPE, Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose phosphate pathway. In the Calvin cycle Ru5P is phosphorylated by phosphoribulose kinase to ribulose-1,5-bisphosphate, which in turn is used by RubisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase) to incorporate CO2 as the central step in carbohydrate synthesis.	1.89619e-33
NZ_CP048838.1\|WP_002606204.1\|4307379_4308048_-\|HAD-family-phosphatase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	1.7732e-34
NZ_CP048838.1\|WP_002606212.1\|4313642_4314488_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	1.1751e-71
NZ_CP048838.1\|WP_002606215.1\|4318465_4318801_-\|hypothetical-protein	gnl\|CDD\|179460	PRK02693, PRK02693, apocytochrome f; Reviewed.	0.000252038

>NZ_CP048838.1|WP_002606212.1|4313642_4314488_+|MurR/RpiR-family-transcriptional-regulator
MSMEFAGRVKGHYYGLSKTEKKIADYLLEHATTARHLSIQELAEDIDVSMSAISRFTKKIGYSNYQEMRLQLSEPFDHLSESFFASLDENDTAMNIAKATFQSGITSLSSTMAVLNQDSLEQAVHLLGRAKTCGLFGMGASSVIVHSAYQRFLRTSLNCQFSLDYHMQLMYAGRLCEKDCALIVSHTGRNKDVLRIVDILKERGVPIISVTSNAASPLARKSDVFLFSISEETKFRPEAISSSVSQLMLMDTLFTLYAIKEDNDPEYFNRIRRIVNTTRIP
>NZ_CP048838.1|WP_002606211.1|4312335_4313229_-|decarboxylating-6-phosphogluconate-dehydrogenase
MEAGLIGLGKMGLHIAMNMQSSGIRAYGYDIQTGPRKQAKAKGISVVQTLQELIAALQKPRIIWLMLPAGDITESMVHQLAELLEEGDYVIDGGNSFYRDSIRNYEFLKKKKIHFYDAGTSGGIRGALEGANFMIGGEREHFAVIEELIQRIASDQGYLYAGDAGSGHYLKMVHNGIEYGMMQAIGEGFELLQHSPYPYDNAQVARLWNHGSVIRSWLMKLAEEAFREDEKLDAVKGIMYASGEGQWTVEEAMRCNVSVPVISTALMMRYRSLYEDTFTGKVVASLRKGFGGHKTAE
>NZ_CP048838.1|WP_002606210.1|4311488_4312310_-|PTS-sugar-transporter-subunit-IIC
MQITIVQAVVISIWIGLVMSRSFLGGATTTLRFTPMMTGLIVGLVFGRVAEAMIITAAIQLIYMGVFSPGGQMPSEPAIAAAIAVPVALLGDMKPEAAIAVAVPVGLLGSYLYQFRFFVNTFVMQKFTDKYAKSANDKMLTISIIFIPILVAFLIFVPFMFVSLYYGAPVIADIVQSTSGSILFHILEVIGGGLASIGIAVTIYVIGKKNYIAFFLLAYFVAVVLKSLNITMITYAIIGTIIAFIFVLSKTEAVSMFSASGINTADNEEEDDY
>NZ_CP048838.1|WP_002606209.1|4310598_4311459_-|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID
MSEMLQKSVNLEPEAITKRDVSLAWLRFYFANEIPHSFDKYIAPSLMWALMPILKKLYKDKKDLSEAYQRHLLFFNTQISWGGGTITGIMASLEAARAQEVYMDTPVTIDDDLIYNTKAGLMGALAGIGDSIDSGTIQYIFIAIALPWAQQGNAIGALFPFVMFSLYQLVIGYYFAQLGFKLGRTAATEVVGTKMQIIIEALSILGLFMMGILAANYVKVSSTLAFTLSGKEFVIQEILDGVMPGILPLLTVGLVYFYFTKKGLNVTKALIGLTIILGVLAGFGIL
>NZ_CP048838.1|WP_002606208.1|4310073_4310580_-|PTS-sugar-transporter-subunit-IIB
MGKVVLARVDARLIHGQVMTSLSKSAGATAIFVADDPSAHDPFTKNIILGAGSRTGLKVRVLKEDGAVRYWNDRQYDDYHVILLTKSIEVMADIIRGGVPMKELNLGGIPQKPGLTSIIKEVAINKEQLKILQELEKDYGIDVYFQAIPSSRRVSLKEAARLFEEHSA
>NZ_CP048838.1|WP_002606207.1|4309645_4310077_-|PTS-sugar-transporter-subunit-IIA
MIGMLLVSHGRMAEGMLDSLELIMGSCDRMHTVSLCAGEDFESFRAKVMEAIRQLDSGDGVLVFVDLYGASPFNASVYAAARMAQEGISVRVLAGMNLAMLLETAAMRVSSSLQELVAIAGAAGLDGISEPLVVKEEENGEDY
>NZ_CP048838.1|WP_002606206.1|4308716_4309646_-|phosphoglycerate-dehydrogenase
MKKVLITPRSFGKYNREELIEKLRQHGIEPVFNPYGTIMNEQQMCSALQDMDGLIVGVDPVSEEALRQAPRLRAIAKYGVGIDNIACAYAQENNIAISRTVNANANAVADYAMTLLMIVARRVVEIDEGCHHNDWSKKEALDIYGKTIGVLGLGAIGKGVVQRASGFDMRVYGYDIMRDDAFLNKYNVCFTDVDTIIRECDFISLHLPLTQETRHILNKDNLKRAKSNLIIVNTARGGLLDEDALYELLKERKLYGLGLDVFEQEPPQNSKLLTLPNVIVSSHTAASTQEAINAMSRMAVENLICSLEA
>NZ_CP048838.1|WP_168389054.1|4308034_4308682_-|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase
MDKTTLLAELKKQRLVAVIRGKDEEEVTNIVDAVYCGGIHFMEITYTIPQAEQVIAHLCKAYEHCDDIIIGAGTCLDIVSARMAISAGAQFVVCPHLDTEVMKLCNSYRVPCFPGAANVKDMLECLRYGADVIKLFPGDTFGPKAVRAFKGPLPQADFMPTGGVSAANLTEWLDNGAVAVGTGGSLTKGAKTGDFEAVRLEAEKLVNIVRAYDQR
>NZ_CP048838.1|WP_002606204.1|4307379_4308048_-|HAD-family-phosphatase
MISDKTELLIFDMDGLLVDTERVYLEGWLYALNKQHVAIAEAVVKSWVGKSFHDTHAYLMQVCHEEALCARIRKDREQYIYQCLENGTLSAMPYARDALQAAREYGYRTGLATSSLKKRSTAILAHLGLLSYLDIPVFADDVIKLKPYPDLYLEVLRRAQVPCEHAAAFEDSLTGVQAAVAAGIQTVRIPDHRFIDVEDTASDVDCAENLSCVRAMLEQLNT
>NZ_CP048838.1|WP_002606203.1|4306427_4307369_-|hypothetical-protein
MEKESVKDVILRYGVLLGKRNTERQKTDFLRAAQKQLEQAGFPVDITCVSASLMRRESVNMYNLYAGDFKKADVVFITYYDTPLWQFYPKEQKAFDANWSRGNFLLHTLLFLCCMIAIAAFLYLTVIPSLQKHGFVSLWGAVLVLVCLFVFYGIRHMRGGIAAGNTMVRNSSSLIALFALASDLSEQEKQHVAFAMIDEGTRSEYGLRMLQEYIGKKRIQRVYLDSIGNVGKLQGFADRHILEGLHEKLAEHAEWHDLAEDKHAYGDILLTSGSCYNGCVSLKIEKRTDNSDLEQQVIKVIQVLKALMISCVS
>NZ_CP048838.1|WP_002606214.1|4316577_4318452_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG
MVDVIVIGGGHAGVEAALACARLKKTTILYSMHIDMIASMPCNPSVGGPAKGIVVREIDALGGEMGKAADATALQFKMLNTTKGPGVQCLRVQSDKLEYKRYMQDKLLQQEYLEIREMCVEEVLAKDGRISGVRQKDGTVVNCRALIMTTGTFMSSTVLVGHTSTLSGPEDEPTTENLSQSLRNLGIETFRLKTGTPARVRTASIDFSKTVVQPGTDEFICFSEDTKEIRPFDQQAVCYLTYTTAKTHDIINRNLKRSAMYSGLVKGVGPRYCPSIEDKLVRFADKERHQIFLEPESESLDTTYVQGFSTSMPYDVQEAMLHSLPGLENCTIEKYAYAIEYDAIDPLQCKPTLENKIIENLYTAGQINGTSGYEEAAAQGLMAGINAVRKLDHKEPLILHRDEAYIGVMIDDLVTKGTKEPYRLLTSRAEYRLLLRHDNADARLSEYGYETGLISDERYARYQKKMQNIEEMISYLAGVRFTPKSTVNGLLERLGLDVLKEGISAAELLKRPGITIALLEPYLEREFDPAIAKLVQIEIRYEGYIKKAKRDAEHLRAMDKVCLPERFDYDQVVNLSLEARQKLNKVQPLTMGQASRISGVNPADIAVLAVFMEQLKRTYKKKSG
>NZ_CP048838.1|WP_002606215.1|4318465_4318801_-|hypothetical-protein
MKYNNSRLSLKQRWLSFALCILIALLAGIFALYSYIEAYPFWRSACSLLVCAIMLFIAIFLLRLNMRRKRIQREFVSEFDKEIRKKEHMCPHCGALMGSGNTCAKCGYKGH
>NZ_CP048838.1|WP_002606218.1|4320764_4321625_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MSSYHSVLKNAQARMEEAGYGEQSALLYMLELTNKEAHNLYMEFDEEMQPELEELYEEGIQRLLTGIPLGHVLGFEWFYGYRFTVNEDVLIPRPETEELVANILAAYDEHFSSQDNVMAVDIGTGSGAIAVSLKKEEPNLHMMATDISEQAVAVAKKNADDNEAIVNFMVGDMLQPLIDRNLKVDILISNPPYIPREEEMEHSVVDYEPHVALFGGDDGLKFYRIIFENAVKVLKERAMMAFEMGYNQKEALSEEAKKYFPNARIEVLKDMSGKNRMLFVYLNMEH
>NZ_CP048838.1|WP_002606219.1|4321624_4322698_-|peptide-chain-release-factor-1
MSVMIERLEGMVNRYHEINEMMMSPEIVTDSRMLAKLGREQADLTQVVETYTEYKNSVSALEDAKALLLEDDKEIKEMAKMEIEELEPKIEEYLEKLEILLIPKDPNDSHNAIVEIRGAAGGDEGNIFAGDLYRMYSKFAESQGWKIEIVEMDDCEAGGFSLVSFMVKGDGVYGKLKFESGSHRVQRVPKTESQGRIHTSTATVLVTPEIEPEDFDIDMNDLEMETMRASGAGGQHINKTDSAVRIVHKPTGITVKCQDGRSQHENRATALMTIRSRVYEEHQRKLEEEQGIERRNKIGTGDRAEKIRTYNYPQNRVTDHRIGYTVNQLDRIMEGRMQDLLDALLSADQQAKLAGEK
>NZ_CP048838.1|WP_002606223.1|4325615_4326155_-|hypothetical-protein
MATIAGGVSMKRRDLIRQKNKLAKTGGFRYIRYAKYACVAMVVLFLVYVGGLSNLSGKSYEELISKSPIVITGFMICTANLYVWYVLKHFLKDLAVPQHVESIRVNLLLMTIGQFILMNFISAVLMMLSLRKYFQWNTFSVKNALKEIRKEGQLSVLIVTALVLILFISLVFGIYFSIR
>NZ_CP048838.1|WP_002606224.1|4326177_4327791_-|PTS-transporter-subunit-EIIC
MKNIQAKLQTFAGAMMVPIILLVLVGFFVGIGSAFTNYILPEGNILYNLFTMITNLGFMFMNNLQLWFAVAIAFTLAKKEKGWAAFAGLILFFCFMRGIEGWAALEGWTAETTTVDALVKSGYTQQAALNFNALWSSSLGIYSYNMGIFSGIVTGLIAAGLHNKFVDTKLPAMFGFFAGTKFVIIMVALASIPLAIAFYYVWPYVAGALQSITGFIRTSGLLGTFVFGTLDKMLLPFGIHHLIAFPIEYTKVGGTMMIDGVMYEGVKNIINGQAASASATGYITRNFTNGRLLFQLAGLPGAAFAMYRCAKPENKKKVASLLVPSVFTLAMVGISEPIEYTFLFVAPALYWLVYAPLCGLCYVAAEITNISINGTALFFMIPNLFQPQKVHAMSALWLLPVTFIVYYFAFKFAITKFNLKTPGRDDEGEIKLMSKKEYNEIKNSGKDEANVSSAPEDALEIRIIEALGGADNIETVTCCASRLRVTVKDDSLIAPDTSWKNYLEAIGVVRGKNSVQVIYGVRVVNITTKVKDYLHLD
>NZ_CP048838.1|WP_002606225.1|4327894_4329256_-|Sapep-family-Mn(2+)-dependent-dipeptidase
MKTIYDTGKRTSELLQDLKQLVEIPSVRDERTAGISAPFGKEIRNAMDVFLQIAQREGFSVHDFDGYAVDAQLGEGDDYIGVLAHLDVVEAGERSHWHGDPFQMREIDGMLYGRGVNDDKGPLLAALYAMARIRQEGRTLYHPIRLIAGGAEETTWECMEHYFKHNPQPICGFSPDGNFPIVNGEKGILQVRFLLNADSDISLHCKERLHIVCDDLQVIVPKGSDVSFVERTNLIEVMHDGIKITYRGVRALSRNPQRGDNAIFKFVKDFHGHLDQASSLYPMVNMIYENFLDDFYGKKSGLYHEDAAMGCGSVCLMSLNTQDGQLELCVDVRYVRSTDEQSLLHTLRKTAQHYGCELEVLRHKRLLYVAEDSTLIQSLKTAYHRVMKEDAAVFTKGGASYARVLDHGVAFGATFPDEDPRPHMPNECMPVKSLLKASDIYYEALVELACTKG
>NZ_CP048838.1|WP_002606226.1|4329368_4330904_+|transcription-antiterminator
MNKRIMKIVDVLLKQDSYITIDKISEELAVSNKTIRNDLQIVDQYLEENNLKLIKKTGVGIRIDGKVRDKLHVLESVREKNKTLADYSPQARKIFIGMQLSAFDSCRIYELSEQLFVSRATIHKDILSLTKDLETFKIALHRKNNNGISMEGKEKNIRNFLLELMLRDNGYQMFIDIIRRDDYRCDGSYVFPGLEVTDDEVKDFTGCILRWGNPYINSLTFPSMVLVLLRAFVTYLRIQDRHIVHLSTSFIEDLRKEPFYKEARELCDRLANHYRLQIPDVEIRYLQVYFLALQNSRDLSEQEQQEARMLSDALLTSWSEQLHLPFDRDEALRQSVYDHLCPAIIRFHHGIPNENPLMQEIHTLYERTFQVARNSVSVIEEHFHCNVSDDEVGFLALHLAASLENMKQPLKTILVAHGGVGAGNLLRRKLSAQIPEIDIISQETFFSIYECDISDIDLIISTLELNLHTDVTILQVNSLLHDYDILRLKDVIREYYKVKNDPYNFKSAAQE
>NZ_CP048838.1|WP_002606227.1|4331160_4331649_-|PTS-glucose-transporter-subunit-IIA
MFGFRKKEKSREELLAVVDGTLIPIEDVKDPVFSQKMMGDGFAIASTGDTVYACADADITMLFPSNHAVGLTLKNGMEILIHVGIDTVNENGNGFTCLCEQGKHVKKGEPLLKMDREYLLSKGYDLSVIVIFTNKDSYAEFRREEPVKVKGGESVAVTYTLP
>NZ_CP048838.1|WP_002606228.1|4331877_4332594_+|pentose-5-phosphate-3-epimerase
MKHIKIAAGLAHVNYGRIADLVKEVSDAGVDYIHSDAADMHDLQNMKLMGGHQIIAGIRPETDKPIECHIYTVSMDRMFIEQIDEAGADMLIIPAEHFIGAQLAYIINWCRERHIKVGLTLGCYTPLCFVEESIYDIDRLHIVTHGVDETDGKDNWGWRKSAIDLVQRARKMIDEKNPKCELAVDGGLRADNMDKLIECNPDVIVLSSAIFKDPDGAAAGVKKCRAAIDAAAEKYGLE

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Crispr_ID: NZ_CP048838_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048838_4

4356705-4356874

TypeI

Consensus_repeat	Method
GTCTAGCCTCCCTGAGGCTAGTGGATTTAAATT	CRISPRCasFinder

2 spacers

cas2,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP048838_4

>merge|NZ_CP048838|4|4356705-4356874|CRISPRCasFinder
GTCTAGCCTCCCTGAGGCTAGTGGATTTAAATTGAAGATTTTAATTGCGATGTAAAGAAAGACCGACGGTCTAGCCTCCCTGAGGCTAGTGGATTTAAATTACTTTTAGCAATCGTACAGATACCTGAATAATCTGAGTCTAGCCTCCCTGAGGCTAGACATTTTAAGCT

>NZ_CP048838|4|4|4356705-4356874|CRISPRCasFinder
GTCTAGCCTCCCTGAGGCTAGTGGATTTAAATT	GAAGATTTTAATTGCGATGTAAAGAAAGACCGACG
GTCTAGCCTCCCTGAGGCTAGTGGATTTAAATT	ACTTTTAGCAATCGTACAGATACCTGAATAATCTGA
GTCTAGCCTCCCTGAGGCTAGACATTTTAAGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048838.1\|WP_002606243.1\|4348240_4350607_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP048838.1\|WP_002606251.1\|4357991_4358855_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|339675
NZ_CP048838.1\|WP_002606310.1\|4365548_4366157_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|226129
NZ_CP048838.1\|WP_002606249.1\|4356245_4356539_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP048838.1\|WP_002606309.1\|4365079_4365535_-\|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl\|CDD\|226389
NZ_CP048838.1\|WP_002606311.1\|4366697_4367600_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372314
NZ_CP048838.1\|WP_002606307.1\|4362995_4364012_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NZ_CP048838.1\|WP_002606246.1\|4353709_4354555_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|187820
NZ_CP048838.1\|WP_156346932.1\|4358980_4360465_-\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NZ_CP048838.1\|WP_002606306.1\|4360951_4362646_-\|M3-family-oligoendopeptidase	unknown	unknown	gnl\|CDD\|341069
NZ_CP048838.1\|WP_002606308.1\|4364001_4364892_-\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|234643
NZ_CP048838.1\|WP_002606312.1\|4367799_4368888_-\|mannitol-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NZ_CP048838.1\|WP_002606242.1\|4346222_4348103_-\|DUF2075-domain-containing-protein	unknown	unknown	gnl\|CDD\|378274
NZ_CP048838.1\|WP_168389055.1\|4351108_4351849_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|273847
NZ_CP048838.1\|WP_002606245.1\|4351832_4353713_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	pfam09709_cas8c_CAS-I-C	gnl\|CDD\|378245
NZ_CP048838.1\|WP_002606247.1\|4354544_4355210_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|273040
NZ_CP048838.1\|WP_002606241.1\|4345167_4346157_+\|P1-family-peptidase	unknown	unknown	gnl\|CDD\|239071
NZ_CP048838.1\|WP_008728643.1\|4357318_4357999_-\|DUF3307-domain-containing-protein	unknown	unknown	gnl\|CDD\|371703
NZ_CP048838.1\|WP_002606240.1\|4343607_4345002_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240543
NZ_CP048838.1\|WP_002606239.1\|4341402_4342836_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587

Protein	Function_ID	Function_description	E-value
NZ_CP048838.1\|WP_002606243.1\|4348240_4350607_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	7.58527e-50
NZ_CP048838.1\|WP_002606251.1\|4357991_4358855_-\|hypothetical-protein	gnl\|CDD\|339675	pfam16264, SatD, SatD family (SatD). This family consists of uncharacterized proteins around 220 residues in length and is mainly found in various Streptococcus species. The function of this family is involved in acid resistance.	1.16918e-11
NZ_CP048838.1\|WP_002606310.1\|4365548_4366157_-\|ECF-transporter-S-component	gnl\|CDD\|226129	COG3601, COG3601, Predicted membrane protein [Function unknown].	2.6773e-33
NZ_CP048838.1\|WP_002606249.1\|4356245_4356539_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.80816e-30
NZ_CP048838.1\|WP_002606309.1\|4365079_4365535_-\|pyridoxamine-5'-phosphate-oxidase	gnl\|CDD\|226389	COG3871, COG3871, Uncharacterized stress protein (general stress protein 26) [General function prediction only].	6.96913e-05
NZ_CP048838.1\|WP_002606311.1\|4366697_4367600_+\|hypothetical-protein	gnl\|CDD\|372314	pfam12784, PDDEXK_2, PD-(D/E)XK nuclease family transposase. Members of this family belong to the PD-(D/E)XK nuclease superfamily. These proteins are transposase proteins.	8.01294e-13
NZ_CP048838.1\|WP_002606307.1\|4362995_4364012_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	5.79736e-135
NZ_CP048838.1\|WP_002606246.1\|4353709_4354555_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|187820	cd09689, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csd2 family.	4.24325e-126
NZ_CP048838.1\|WP_156346932.1\|4358980_4360465_-\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NZ_CP048838.1\|WP_002606306.1\|4360951_4362646_-\|M3-family-oligoendopeptidase	gnl\|CDD\|341069	cd09606, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3 oligopeptidase F (oligendopeptidase) is mostly bacterial and includes oligoendopeptidase F from Geobacillus stearothermophilus. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids and may cleave proteins at Leu-Gly. The PepF gene is duplicated in Lactococcus lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid.	0
NZ_CP048838.1\|WP_002606308.1\|4364001_4364892_-\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|234643	PRK00114, hslO, Hsp33 family molecular chaperone HslO.	1.2098e-124
NZ_CP048838.1\|WP_002606312.1\|4367799_4368888_-\|mannitol-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	3.45714e-58
NZ_CP048838.1\|WP_002606242.1\|4346222_4348103_-\|DUF2075-domain-containing-protein	gnl\|CDD\|378274	pfam09848, DUF2075, Uncharacterized conserved protein (DUF2075). This domain, found in various prokaryotic proteins (including putative ATP/GTP binding proteins), has no known function.	3.22391e-114
NZ_CP048838.1\|WP_168389055.1\|4351108_4351849_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|273847	TIGR01876, cas_Cas5d, CRISPR-associated protein Cas5, subtype I-C/DVULG. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum. This family belongs to a set of several Cas protein families, one each for a number of different CRISPR/Cas subtypes, that share a region of N-terminal sequence similarity modeled by TIGR02593. This family represents the Dvulg subtype of CRISPR/Cas locus.	1.49668e-78
NZ_CP048838.1\|WP_002606245.1\|4351832_4353713_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	6.53173e-135
NZ_CP048838.1\|WP_002606247.1\|4354544_4355210_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	1.09575e-30
NZ_CP048838.1\|WP_002606241.1\|4345167_4346157_+\|P1-family-peptidase	gnl\|CDD\|239071	cd02253, DmpA, L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active heterodimeric form. The cleavage results in two polypeptide chains, with one chain containing an N-terminal nucleophile. This group represents one of the rare aminopeptidases that are not metalloenzymes. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	6.69177e-148
NZ_CP048838.1\|WP_008728643.1\|4357318_4357999_-\|DUF3307-domain-containing-protein	gnl\|CDD\|371703	pfam11750, DUF3307, Protein of unknown function (DUF3307). This family of bacterial proteins has no known function.	1.70486e-08
NZ_CP048838.1\|WP_002606240.1\|4343607_4345002_-\|MATE-family-efflux-transporter	gnl\|CDD\|240543	cd13138, MATE_yoeA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	2.75116e-124
NZ_CP048838.1\|WP_002606239.1\|4341402_4342836_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	2.03156e-128

>NZ_CP048838.1|WP_002606249.1|4356245_4356539_+|CRISPR-associated-endonuclease-Cas2
MLVIITYDVNTQNSAGKKRLRNVAKVCVNYGQRVQNSVFECVMDQAKCREVKHKLTGLIDKEHDSLRFYYLGNNYKNKVEHIGVKPSFNVEEDVLFI
>NZ_CP048838.1|WP_002606247.1|4354544_4355210_+|CRISPR-associated-protein-Cas4
MEYSEDEFLMLSGIQHFAFCRRQWALIHIEQQWAENYRTIDGQIFHENAHNGAFSETRNGILIRRGLSVFSRTMGISGNCDIVEFHPSEEGISISKDSKRYLPVPIEYKRGEPKQYQADDLQLCAQAMCLEEMLLCKIEKGCLFYGETRRRTEVLFSSDMRSTVKAFCEEMHKLYLKQYTPKVKISKKCNACSLKDICLPKLNQNPSVDKYFDKYLGDKGI
>NZ_CP048838.1|WP_002606246.1|4353709_4354555_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MTTFTNKVDFAVIFTVNKANPNGDPLSGNQPRIDFKGFGEVSDVCMKRKIRNRLQDMGENIFVQSDERSNDGFKSLSERASNNKELKAVLKDREAYASAACKQWTDVRAFGQVFAFKANNVSVGVRGPVSIRTAESINPVVTTDMQITKSVNSEPSEKRSSDTMGMKHRVDFGLYVCKGSINHQLAEKTGFSEEDAEKIKEALCSLFMNDASSARPEGSMEVCKVYWWKHNCLAGQYSSAKVHNSLKVEVKNDVDTPNCFEDFTITLSPLEGLEPEIYDGI
>NZ_CP048838.1|WP_002606245.1|4351832_4353713_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSWASKLLETYDICQSEVGEESETGMLLPLSHLTTKAQIEVVLDENGKFIHAIEIPNDDAVTVIPVTEDSASRSSGITPHPLHDKLIYISKDYAEYTGKRNDPHVLAHQNLLRQWVDSSYTHTSLVPIYQYLEQGTLLFDLISCDILKLDGEQLDKKYKIQKTVVQTEAFVRFKIRGKQKRIVEPWCDKMLFDAYHNFYTSQHTDEDLCYITGKMMYCTEKHPAKLRQGKDKAKLISTNDANGFTYRGRFVSKKEAISIGYETSQKIHNALRWLIQKQAYKQNGQTILVWNAHCDNIMTAFALDESLFPALPDKVDTEEDFAQRVNKAIDGYRKNISDHNDNIVIMAMDAATIGRFSITYYQEIDASTYYKHLQNWFTYCSWPQYSKADYMSDVMTPIPREIISCAYGTLRGAFFEVDDQLMTLQMGRLLPCISEGKPIPDDFIIRLNNQIKTMSTNTKYNWNKCIGILCAVFKKYCYDREGVNWSVNIMENKKLAKSNIPYLLGRILAIYDAIEQYALNIQKEDRPTNAMRLYAPFQEHPFVTLTTIDKKIRPYVEKLGRKCDYLLSMKQDLMEELYTEMDIEAVEHIQNLNAYFVIGFDCQRNEIKRINTERKEKNKQKEESKL
>NZ_CP048838.1|WP_168389055.1|4351108_4351849_+|type-I-C-CRISPR-associated-protein-Cas5
MQKKNEITFSVKSKYTLFSDPLNRVSGEKFSYQIPTYEALKGVVKSIYFKPTISWIIDEVRIMNEIQFTTQGIRPINYHGGNTLSYYTYLTDVEYQVKAHFEWNLHHEELEQDRNENKHWLIAKRMVNRGGRRDVFLGTRECQAYVEPCEFGEGKGFYDDHTIIPFSTMVHGFIYPDEWVCEEEKDKLIATFWTPVMKKGIITFIRPEQCAIRRIVGTGDIKRFEKDINFKSVDQEEGGELHELGE
>NZ_CP048838.1|WP_002606243.1|4348240_4350607_+|CRISPR-associated-helicase/endonuclease-Cas3
MNILAHINNKQEMQSLQEHSVNTFTAIKEYAAARGLTNCMKLIAFLHDCGKASKEFQKYITKAAMENIFLPKVNHSSAGAQILLEACRFYNNMSECLVKLMFANAIVSHHGLCDFINVHGDNALRSRCYPEKSLDMNHITTFMNDFISTEELEKLFRAAHKEISVYLANFMKQRTVKDAKDYYFYIGALQRLLMSLLIHGDREDTRNFMEQTKTIVYTEDTIWQAATDKLESHLAEITANSSFNPINELRASISDQCKAFSSHSPGIYRLSCPTGSGKTLASLRYALHHAKKYHKKHIIYVAPFKTILEQNAEVMKQFFNEDLVLEHHSNIIPSQYTDYDYYSSSWNKPVILTTAVRLFDVMFKDRTTDVRRFHQLADSVLIIDEAQKIPVQTISMFNEMMNFLAYNCNTTVVLCTATQPLLETTTYPIKLASESEIVKQTKEMQEQFKRVHIEDACRRGGYSIADLSDFIFQKLQPGCSMLVIVNTKAEALNLYRACEQHHEIDGLHLYHLSTSMCPEHRHLTLEDLKEHMEQKDTVLCIATNLIEAGVDIDCDVVIRSLCGLDSILQAAGRCNRNGKNSELGTVYLINSNEEHIEKLKDVRKGQNETDILLSQLHASKEGNRVDELLTLPFIRQYYDSYLFDRRQDTEYSTKIENRKVSLFDLFSRIGSKNESDDLAHPCLGHALKSAGEKFEMIDSQSIGVLVPYKDGEKLINQLNSSISNAEKYALLDKTQRFMVNVYEHKYKELEKEDMIYKLEFNGMLVLRDGFYNKDTGLEVRKELEDMFV
>NZ_CP048838.1|WP_002606242.1|4346222_4348103_-|DUF2075-domain-containing-protein
MLIYEGTKYDFRMDMDLDKIPHLLEEKLYEHMHIHTSKKEVMSWKNSLQYMYKVLNDSHIPDACGVAIEYNIPKTNKRVDFIMSGYDHNGKASAIIIELKQWERVETVFNRDDLINTEVMTALGKGVHRVVHPCYQAWSYVQHMNDYIEEVGKKDIQLYPCAYLHNYDLEKEQNIINPIYNACIEKSPLFTQGEIPRLREFIKKHLKQGDHKEVLYLIENGRIRPSKSLQDCISSMLDGNQEFTMLDTQKVVFEEILYMARLCQKDKRKRVMIAKGGSGTGKSVIAVNAMVNLLKEDMFGQYITKNAAPRNVYIDRLAGKMKKNKIKSLFAAPDKFYQQQPNDYDFLIVDEAHRLREKSGMFQKGENQIQELISSSLFTVFFIDSYQRVHFRDFGSISEFQKQAQLQNAEVIQYELHSQFRCNGSDGYLAWIRNMLQLEETANFNFKDISFDFRVIDDPNELRAMICEKNDESGKARILAGYCWEWEKAGRSDPNHDDIVIGDFKMSWNLDAGDPYAISQGSVHQVGCIHTTQGLEFDYVGVIIGEDLRYENNELVTDYRQRAKTDSSVKGLKKLYRENPEKAKHIERQIILNTYYTLMTRGMKGCYIYCCDSELQKYIKMSIADA
>NZ_CP048838.1|WP_002606241.1|4345167_4346157_+|P1-family-peptidase
MKKGYRNKITDVKGVRVGHKTIAAGNVQTGVTVILPTEGDIFREKLTASCHVINGFGKTGGLIQLEELGVLESPIALTNTLCVGTVQQALVRYMLQDHPEIGTTSGTVNVVVGECNDGYLNDIRACSIQESNVYEAIADAGKDFALGAVGAGRGMSCFEMKGGIGSASRVLELNGEEYTVGLLVLSNFGLKNDYIKENVSFHDSVKEQVEQGSIIIILATDIPMSDRQLKRVCKRMPVALARLGSHLGNGSGDIAIAFSTANKIPHSADCSFISQTILHEQQIDKVFRAGIEACEEAIQSSLDAAETVVGREGHCRYSLQDTVAEMKKG
>NZ_CP048838.1|WP_002606240.1|4343607_4345002_-|MATE-family-efflux-transporter
MQEKGILQGNLTKALLRMAVPLFVLNLVNSLYNIIDTFWVGQLGELQVGAVSLVGPIMWCAQSVAMGLSAAAIALLSTRLGANQKGDACRFATALLYFAIGFAIVLSIGTLLLLHPILSWLDTPKEIYDTSYQYLLGISFDYIGLLMLNLYMAMRQSAGDSRSGVKLNMCASLLNAILDPIFIFVFHFGILGAAIATVVSKLVMVPIAWRRLHDKAFPVHIDFRAYPFHAADGKIILKLCIPAASGQFLENLGFVIMNKYIVYYGAVAISAYGVGAKMVTLAYIPVMSIGAVLATFVGQNLGAGNTERARKAFHTAMKLSTLFSSTLTIIGMLVITPFIHLFVPNASTQLMELTQEYAFFALLCGVFMGWYINLNDGVFNGSGHTNYTFILSMMRLWAFRIPMILLFHRFTSLGITGIWLAMLLSNIFECILAQAIYLRHRWEHSAILTETERIQPSEETVKEI
>NZ_CP048838.1|WP_002606239.1|4341402_4342836_-|DEAD/DEAH-box-helicase
MKFEDYKLDASICEALHTLGYQSPLPVQEAVIPLMLEKKDILVKSRTGSGKTASFAIPIIQDLIWEERSPQALVLSPTRELALQIKGEFDNIGAYKRIKTAAVFGKQPFRFQAQDVKQRTHVVAGTPGRVLDHLEQGTLRTDKIRYIIIDEADEMLNMGFIETVQKIFFRLPKNASVCMFSATLPQEIQELAHDFLKQAEVVEIESQTSVSEQMHHYAYRLKEHEKPQALLKLLCRELPESCIIFAKTQEHVREICRMLYDKGISVDQLHGGMLQEDRLENMKDFRLGKLRILTATDVAARGIDIQDVTHIINYDMPNKKETYIHRIGRSARLDRSGTAISFVSQYDDFRLQELEEYLGNALEFHDSSELEAVIADAETLRKLGTPKSQKEEKGKELRKDMMKLYLGGGKTKKIRPGDIVGAICEIEGVCGDDIGVIQVQDYQSYVDILHGKGLQVLRALRQKTIKGKKLKVERAKE
>NZ_CP048838.1|WP_008728643.1|4357318_4357999_-|DUF3307-domain-containing-protein
MHNMLLFIIFHVVGDFYLQSDEVAKNKENLNTFMLIHSIIYSIPFVLLFIYFKINVSLLIIITLSHLLIDVCSVKLKNKYKEKECLIFCSDQFIHIFIIYLCSSYMNLTIILSNMALISILAILILVKPTGVLISLAFKVIFKEEKSNHELKIGTYIGYLERIIIFLLCIFDSISTIGFIIAAKTLVRYKDINNNKNHFQEKYLIGTLLSTIGALCCFALIKFLST
>NZ_CP048838.1|WP_002606251.1|4357991_4358855_-|hypothetical-protein
MIDIVDSRKYKNRNEIQEFMKCIIVYLNKIFYKSLKKPLMFSAGDEIQGLFYEPLAAYLCVRFCMMICYPVKIRAGIGYGELAFDNENWKSSELDGEVYHNARYAIESFSGKNSFGIRINTKTKKDKYLNAMLYSSQLLQRQQSVNVQNVKLIAELLYPIFDENIMVSYIEFKDQLNFILEMKANIVPVQSLSYARIGSSPKGELKNNIVISNDIGQVNFMPLRKLLEDSNMLVENTWKKGMSTMISEILGTTRQNIDKHIRLGNIDENRKIDFSVACWLIEELDNA
>NZ_CP048838.1|WP_156346932.1|4358980_4360465_-|lysine--tRNA-ligase
MEKLTEQEVIRRQKMEDLRAMGIEPFGHAYQRTHKSGEIRAAYEDCTKEELEEKDLTVKIAGRIMTKRRQGKAGFMHIQDIDGQIQIYVRKDVIGEEAYEVFKKSDLGDIVGIEGKVMKTNHGELSVKAEVYTHLTKALRPLPEKYHGLQDVEERFRRRYVDLITNENSKRIALTRPRIIRAIQNYLDNEGLVEVETPVLQPILGGASARPFVTHHNTLDMPFYLRIATELPLKRLIVGGLEGVYEIGRLFRNEGMDATHNPEFTTVEAYVAYSDLSGMMDLVEGLLNHVAEKVCGTTEIEWQDKTISLKAPFKRLHMVDGIKEACGVDFWQEMSFADACAIAKEHDIEVEKKHNSVGHIINLFFEKYVEETLIQPTYVYGHPVEISPLAKKNAQDPRFADRYELFIDGHEYANAFSELNDPIDQRERFENQLKLRDLGDDEANEMDTDYVEALEYGLPPTGGVGLGIDRLVMLLTNSQTIREVLLFPHMRLNK
>NZ_CP048838.1|WP_002606306.1|4360951_4362646_-|M3-family-oligoendopeptidase
MKFKDYNYERYSFEAYAEAMQQAGTRLKEAKDYQSFKKAFDEGKRAFEHLDTMYNICYVRYTINTNDAFYQKENDYWDEAMPKMKSLTTAFDKEVLASPFAEELKKDVPETYFLLAEFAQKSFCDEIIEELQEENRLQSSYQKLIASAQIPFDGDIYTLSELGVKMECDDRDIRKRATQAYWGWMQSHQDEIDDLYDRMVKVRDRMAKKLGYKNYVELAYMLQCRFDYKQEDVANYRRQVLEDVVPLCNALYERQRERLGYDRLHVYDEKYEFASGNPTPKYDTQEMIARANTMYHELDERCGTFFDFMVEHDLLDLDSKKGKAGGGYCTVFAEDRSPFIFSNFNKTSHDAEVLTHEAGHAFQVFTSMGIRPVECIWPTYESCEIHSMSMEFFTWPWMETFFEEDADKYRFLHLGGAAKFIPYGVLVDHFQHEVYEHPEMTPAERRQTWRRLEKQYLPHKDYTDCEFLENGGWWFRQSHIFMTPFYYIDYTLAQVCALQFWYRLYQKDENAFEDYYRICQIGGTKTFTQIVAAANLKVPFADGCLKDVMKAVRSYLDQVDDKAL
>NZ_CP048838.1|WP_002606307.1|4362995_4364012_-|tRNA-dihydrouridine-synthase-DusB
MPNNSWKIRDIVIPNQVVIAPMAGISNPAFRVICKEFGAGLIYTEMVSDKALYYDNEKTVGMTDVEEQEHPLAMQIFGHDIETMVYAAKFLDEKTDCDIIDINMGCPVTKIVKSFAGSALMKDVDHAVEMSRAVIQSVKKPVTVKMRIGWDLDQITCLELARGLEAVGVQALAVHGRTRKQMYEGTADWSYIKKVKEAVSIPVMGNGDVRSGEDAKRMLKETGCDAVMIGRGVLGDPWLIKDIAHYLECGKHMPEVTLEETFAMARLHAKRLCNLKGEFVGIREMRGHAAWYVKGLPKSHQLKDQLSKIETYEEMQSILSAYEAEYARIQEQYKQGNR
>NZ_CP048838.1|WP_002606308.1|4364001_4364892_-|Hsp33-family-molecular-chaperone-HslO
MMKDYLVKALACNEHVRIYICSSTHMVEEARKRFDLWPTSAAALGRVLTVGSMMGSMLKTAQEQITIRINGGGPIGTILVDAYSDGHVRGFVSDPHIMLQYNDTGKLAVGAAVGKDGYLEVVKDMNMKENWSGTVALQSGEIGDDFAYYFTASEQTPSAVSVGVLVDTDNSILSAGGMIIQMLPDAEEEDIVKVEQIVANLRHMSTMIQEYESLEDILRDLFDDVRILTGQDIEFRCKCDRATMKRVLTTLPKEERQQMIEEDHGCEITCNFCGEKYQFSEEELLELERFMDAHAK
>NZ_CP048838.1|WP_002606309.1|4365079_4365535_-|pyridoxamine-5'-phosphate-oxidase
MTFEEGVALLFHKLGDSKIMALGSSVNDYVMVRNVSCLFYDGKIYFKTDKNFRKTQQLYRNPQVALCTGGVQVEGIAVNKGLVVDEPGRRFEALYKKYLWQSYNAYSHEDTEILIEVTPRFVEIWDEDENRNAFQIFLDFDKKTVEIKPYD
>NZ_CP048838.1|WP_002606310.1|4365548_4366157_-|ECF-transporter-S-component
MKNNMSAKRLALIGMLGALGAILMMFRFPIPFMPPFLSFDLAAIPELIGAFALGPVAGVLIVFIRVMVQMVISGSNSMFTGELQSFLLGVALVLPASLLYRHKKTRKEALLGMTAGTLVSTLVAVLTNLYLIIPFYVALYDMNMDQIILSCSKVNPMMNSVTTMVILGIVPFNLIKYGISCLITFAVYKKISPMIHRFANRQ
>NZ_CP048838.1|WP_002606311.1|4366697_4367600_+|hypothetical-protein
MSNTMNQLNYSNDLFFKYTLSREDEGSVYARNTIIERVTGIRVKESTVLNPNLDPGIIGKKRIILDVHVKDEQNRHFNIEMQTTYKGLAEMMRFEFYGARALNNQLNSGKKYKDLKPVYQIIFIDEYAWNNRNLINQYQMRNEQGENESYYPLILRTYIHMPAINDIVREKEILRLNDFEQLIYLFENNEKNDILKSKERLVKVFVDKYEEMQKDDELWSTAMAIQMGEARYRYGLEDSFEEGKKEGEALLLIKQLKSKYHEDCTTWLQSLNDEQIEAVSSLILVCNSFQELKDQVMSMK
>NZ_CP048838.1|WP_002606312.1|4367799_4368888_-|mannitol-dehydrogenase
MKEAVLIGAGQTGRGFIAPILQANAYHITFIDKNKELIDRLNAEKSYPVHYFGDGKEPVTISGYDAYTTADEEVIEKLAHSDLITTSVFAGNIKELVGLLSAAAEQCGEKQLRIVCCENGVHVKQPLVDANISNSISEGVIFCTTLQPKEKSLVLISEDVAELPVDGSVKGMLPDIVGMPLEADFPSLIQRKIYTYNFMSAIVAYLGDYLQYEVYGEAANDPQIMELMDRAVPVVSTIIAREYAVEQDVQLAFTMRAVHKFRNREIYDTVYRNARQAQRKLNKEERLYEPLRLAEKYGQKCGYILLAAAAAMRYAVVKENSNPDTLMKMYENFHSADKLKEVYGLLKESISLKDVIKFCAEF

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP048838_1	1.4\|1263913\|35\|NZ_CP048838\|CRISPRCasFinder,CRT,PILER-CR	1263913-1263947	35	MT001829	Salmonella phage SE_PL, complete genome	249355-249389	8	0.771
NZ_CP048838_1	1.4\|1263913\|35\|NZ_CP048838\|CRISPRCasFinder,CRT,PILER-CR	1263913-1263947	35	MK773491	Salmonella phage 7t3, complete genome	99376-99410	8	0.771
NZ_CP048838_1	1.4\|1263913\|35\|NZ_CP048838\|CRISPRCasFinder,CRT,PILER-CR	1263913-1263947	35	MK268344	Salmonella phage Munch, complete genome	36688-36722	8	0.771
NZ_CP048838_2	2.19\|1593680\|34\|NZ_CP048838\|PILER-CR,CRISPRCasFinder,CRT	1593680-1593713	34	KC954775	UNVERIFIED: Cronobacter phage S13, complete genome	180132-180165	8	0.765
NZ_CP048838_2	2.19\|1593680\|34\|NZ_CP048838\|PILER-CR,CRISPRCasFinder,CRT	1593680-1593713	34	NC_028773	Cronobacter phage S13, complete genome	180132-180165	8	0.765
NZ_CP048838_2	2.2\|1592523\|34\|NZ_CP048838\|PILER-CR,CRISPRCasFinder,CRT	1592523-1592556	34	NC_005128	Vibrio vulnificus YJ016 plasmid pYJ016, complete sequence	37237-37270	9	0.735
NZ_CP048838_2	2.4\|1592656\|34\|NZ_CP048838\|PILER-CR,CRISPRCasFinder,CRT	1592656-1592689	34	AP019515	Halomonas sulfidaeris ATCC BAA-803 plasmid pBAA-803-A DNA, complete genome	203356-203389	9	0.735
NZ_CP048838_2	2.4\|1592656\|34\|NZ_CP048838\|PILER-CR,CRISPRCasFinder,CRT	1592656-1592689	34	NZ_CP011053	Halomonas sp. KO116 plasmid unnamed1, complete sequence	253744-253777	9	0.735
NZ_CP048838_2	2.4\|1592656\|34\|NZ_CP048838\|PILER-CR,CRISPRCasFinder,CRT	1592656-1592689	34	MH319754	Marine virus AG-345-L05 Ga0172272_11 genomic sequence	100747-100780	10	0.706

1. spacer 1.4|1263913|35|NZ_CP048838|CRISPRCasFinder,CRT,PILER-CR matches to MT001829 (Salmonella phage SE_PL, complete genome) position: , mismatch: 8, identity: 0.771

ttgctttgccataattactccaaataattacgatg	CRISPR spacer
tttctttgccataattactccaaatcaggattttt	Protospacer
** ********************** *  *.  *

2. spacer 1.4|1263913|35|NZ_CP048838|CRISPRCasFinder,CRT,PILER-CR matches to MK773491 (Salmonella phage 7t3, complete genome) position: , mismatch: 8, identity: 0.771

ttgctttgccataattactccaaataattacgatg	CRISPR spacer
tttctttgccataattactccaaatcaggattttt	Protospacer
** ********************** *  *.  *

3. spacer 1.4|1263913|35|NZ_CP048838|CRISPRCasFinder,CRT,PILER-CR matches to MK268344 (Salmonella phage Munch, complete genome) position: , mismatch: 8, identity: 0.771

ttgctttgccataattactccaaataattacgatg	CRISPR spacer
tttctttgccataattactccaaatcaggattttt	Protospacer
** ********************** *  *.  *

4. spacer 2.19|1593680|34|NZ_CP048838|PILER-CR,CRISPRCasFinder,CRT matches to KC954775 (UNVERIFIED: Cronobacter phage S13, complete genome) position: , mismatch: 8, identity: 0.765

--aataatatatccaaggcattttatttcctttatt	CRISPR spacer
ctaaca--atatccaacgcatattatttccttagta	Protospacer
  **.*  ******** **** ********** .*

5. spacer 2.19|1593680|34|NZ_CP048838|PILER-CR,CRISPRCasFinder,CRT matches to NC_028773 (Cronobacter phage S13, complete genome) position: , mismatch: 8, identity: 0.765

--aataatatatccaaggcattttatttcctttatt	CRISPR spacer
ctaaca--atatccaacgcatattatttccttagta	Protospacer
  **.*  ******** **** ********** .*

6. spacer 2.2|1592523|34|NZ_CP048838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005128 (Vibrio vulnificus YJ016 plasmid pYJ016, complete sequence) position: , mismatch: 9, identity: 0.735

-tatgtcagcgctctttcttccttaacttctctca	CRISPR spacer
aagtgtt-ccgctcgttcttccataacttctctat	Protospacer
  .***.  ***** ******* **********

7. spacer 2.4|1592656|34|NZ_CP048838|PILER-CR,CRISPRCasFinder,CRT matches to AP019515 (Halomonas sulfidaeris ATCC BAA-803 plasmid pBAA-803-A DNA, complete genome) position: , mismatch: 9, identity: 0.735

gtgaaagcatgttgaatcgaaacagcacctcttg	CRISPR spacer
cctaaagcatgctgaatcgaaaaagcagcgtgtg	Protospacer
 . ********.********** **** * . **

8. spacer 2.4|1592656|34|NZ_CP048838|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011053 (Halomonas sp. KO116 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

gtgaaagcatgttgaatcgaaacagcacctcttg	CRISPR spacer
cctaaagcatgctgaatcgaaaaagcagcgtgtg	Protospacer
 . ********.********** **** * . **

9. spacer 2.4|1592656|34|NZ_CP048838|PILER-CR,CRISPRCasFinder,CRT matches to MH319754 (Marine virus AG-345-L05 Ga0172272_11 genomic sequence) position: , mismatch: 10, identity: 0.706

gtgaaagcatgttgaatcgaaacagcacctcttg	CRISPR spacer
acttcattatcttgaatcggaacagcacctctag	Protospacer
..   * .** ********.************ *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

4009736 : 4021910

Listeria_phage(18.18%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_008728329.1\|4009736_4010183_-	hypothetical protein	Q6JIG5	Burkholderia_virus	4.5e-27	48.8
WP_157133774.1\|4010226_4011123_-	hypothetical protein	NA	NA	NA	NA
WP_008728327.1\|4011654_4012083_-	hypothetical protein	NA	NA	NA	NA
WP_008728326.1\|4012167_4012323_-	hypothetical protein	NA	NA	NA	NA
WP_118002257.1\|4012394_4012742_-	hypothetical protein	NA	NA	NA	NA
WP_008728324.1\|4012734_4013073_-	hypothetical protein	NA	NA	NA	NA
WP_008728323.1\|4013084_4013552_-	single-stranded DNA-binding protein	A8ASP5	Listeria_phage	5.2e-34	52.8
WP_008728321.1\|4013548_4013953_-	hypothetical protein	H0USU9	Bacillus_phage	9.7e-21	44.0
WP_008728319.1\|4013949_4014423_-	class I SAM-dependent methyltransferase	A8ATY8	Listeria_phage	2.6e-49	58.4
WP_008728317.1\|4014422_4014587_-	hypothetical protein	NA	NA	NA	NA
WP_008728316.1\|4014589_4015342_-	site-specific DNA-methyltransferase	B4XYT3	Lactobacillus_phage	8.2e-98	65.6
WP_008728314.1\|4015357_4016095_-	site-specific DNA-methyltransferase	A0A0F7ILF2	Polaribacter_phage	1.2e-72	60.4
WP_008728313.1\|4016236_4017013_-	DnaD domain protein	R9U9G0	Vibrio_phage	1.4e-20	45.9
WP_008728311.1\|4017032_4017197_-	hypothetical protein	NA	NA	NA	NA
WP_050804752.1\|4017198_4017576_-	DUF1064 domain-containing protein	A0A0U2C0S3	Paracoccus_phage	3.7e-14	45.0
WP_008728306.1\|4017568_4018234_-	hypothetical protein	A0A2H4J972	uncultured_Caudovirales_phage	5.5e-29	39.5
WP_008728304.1\|4018237_4018813_-	hypothetical protein	NA	NA	NA	NA
WP_008728302.1\|4018822_4019314_-	siphovirus Gp157 family protein	NA	NA	NA	NA
WP_008728300.1\|4019315_4019957_-	ATP-binding protein	A0A2I7R7K9	Vibrio_phage	3.7e-30	36.9
WP_008728299.1\|4019968_4020676_-	hypothetical protein	NA	NA	NA	NA
WP_008728297.1\|4020688_4020934_-	hypothetical protein	NA	NA	NA	NA
WP_008728295.1\|4021181_4021910_-	hypothetical protein	A0A2R2ZGJ4	Clostridioides_phage	3.8e-31	55.3

DBSCAN-SWA_2

4164248 : 4231180

Streptococcus_phage(73.68%)

integrase,transposase,tail

attL 4167405:4167422|attR 4203810:4203827

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002606076.1\|4164248_4164632_+	YdcP family protein	A0A1S5SF96	Streptococcus_phage	4.0e-32	55.9
WP_002606077.1\|4164725_4165139_+	DUF5301 domain-containing protein	NA	NA	NA	NA
WP_002606078.1\|4165243_4166623_+	hypothetical protein	A0A1S5SFB5	Streptococcus_phage	1.6e-171	66.0
WP_002606079.1\|4166633_4167038_+	hypothetical protein	NA	NA	NA	NA
WP_002606080.1\|4167284_4168481_+	XRE family transcriptional regulator	A0A1S5SEX3	Streptococcus_phage	1.5e-149	63.0
4167405:4167422	attL	NA	NA	NA	NA
WP_002606081.1\|4168493_4168628_+	DUF3789 domain-containing protein	NA	NA	NA	NA
WP_002323342.1\|4168628_4168850_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	9.0e-29	87.7
WP_002303262.1\|4168935_4169178_+	DUF3781 domain-containing protein	NA	NA	NA	NA
WP_002606082.1\|4169174_4169645_+	effector binding domain-containing protein	NA	NA	NA	NA
WP_002606083.1\|4169732_4169960_+	hypothetical protein	NA	NA	NA	NA
WP_002606084.1\|4169947_4170445_+	conjugal transfer protein	NA	NA	NA	NA
WP_002606085.1\|4170460_4170967_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	4.3e-42	50.6
WP_002606086.1\|4171081_4171480_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	9.2e-48	74.0
WP_002606087.1\|4171457_4173908_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	76.1
WP_002606088.1\|4173907_4176121_+	MFS transporter	A0A1S5SF30	Streptococcus_phage	1.3e-188	60.6
WP_002606089.1\|4176117_4177125_+	peptidase P60	A0A1S5SEZ8	Streptococcus_phage	7.8e-136	70.5
WP_002606090.1\|4177141_4178044_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	1.2e-79	52.3
WP_002606091.1\|4178099_4178633_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_002606092.1\|4178764_4179232_+	hypothetical protein	NA	NA	NA	NA
WP_002606093.1\|4179249_4179423_+	hypothetical protein	NA	NA	NA	NA
WP_074050148.1\|4179416_4179860_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_002606095.1\|4179872_4180097_+	hypothetical protein	NA	NA	NA	NA
WP_002606096.1\|4180376_4180805_+	hypothetical protein	A0A1S5SEW0	Streptococcus_phage	2.1e-21	41.6
WP_003865497.1\|4180794_4181037_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_002347229.1\|4181411_4181615_+	excisionase	A0A1S5SF07	Streptococcus_phage	1.9e-25	82.1
WP_002606098.1\|4181693_4182884_+\|integrase	site-specific integrase	A0A1S5SEW7	Streptococcus_phage	1.6e-156	67.3
WP_002606099.1\|4183158_4183356_-	cold-shock protein	Q9AZD3	Lactococcus_phage	2.7e-16	60.3
WP_002606100.1\|4183383_4184052_-	ComF family protein	NA	NA	NA	NA
WP_002606101.1\|4184048_4185203_-	DEAD/DEAH box helicase family protein	A0A1X9I5S6	Streptococcus_phage	4.4e-50	33.0
WP_002606102.1\|4185361_4186372_-	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	4.8e-101	52.4
WP_038274051.1\|4186629_4187634_-	SIS domain-containing protein	NA	NA	NA	NA
WP_168389049.1\|4187663_4188500_-	PTS system mannose/fructose/sorbose family transporter subunit IID	NA	NA	NA	NA
WP_002606105.1\|4188483_4189257_-	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_008728158.1\|4189342_4189819_-	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_002606107.1\|4189984_4190404_-	PTS fructose transporter subunit IIA	NA	NA	NA	NA
WP_002606108.1\|4190417_4191239_-	TIM barrel protein	NA	NA	NA	NA
WP_168389050.1\|4191228_4193985_-	sigma 54-interacting transcriptional regulator	NA	NA	NA	NA
WP_040005137.1\|4194264_4195785_-	ATP-binding protein	G8DDJ2	Micromonas_pusilla_virus	2.0e-10	30.9
WP_002606112.1\|4196130_4197126_-	hypothetical protein	NA	NA	NA	NA
WP_002606113.1\|4197147_4199067_-	hypothetical protein	NA	NA	NA	NA
WP_008728154.1\|4199227_4201945_-	hypothetical protein	NA	NA	NA	NA
WP_081615996.1\|4201998_4202292_-	GPW/gp25 family protein	NA	NA	NA	NA
WP_002606116.1\|4202374_4203136_-	hypothetical protein	NA	NA	NA	NA
WP_038274243.1\|4203140_4203416_-	hypothetical protein	NA	NA	NA	NA
WP_002606118.1\|4204201_4204804_-	hypothetical protein	NA	NA	NA	NA
4203810:4203827	attR	NA	NA	NA	NA
WP_002606119.1\|4204808_4205585_-	hypothetical protein	NA	NA	NA	NA
WP_008728147.1\|4205571_4205985_-\|tail	phage tail protein	NA	NA	NA	NA
WP_168389051.1\|4206196_4206586_-\|tail	phage tail assembly protein	NA	NA	NA	NA
WP_002606122.1\|4206596_4207028_-\|tail	phage tail protein	NA	NA	NA	NA
WP_002606124.1\|4208458_4210177_-\|tail	phage tail sheath family protein	H6WFT7	Cyanophage	1.3e-18	29.5
WP_002606125.1\|4210275_4211151_-	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_002606126.1\|4211153_4211537_-	DUF4280 domain-containing protein	NA	NA	NA	NA
WP_002606127.1\|4211538_4212087_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_002606128.1\|4212083_4213412_-	MORN motif containing protein	NA	NA	NA	NA
WP_002606129.1\|4213408_4214194_-	hypothetical protein	NA	NA	NA	NA
WP_002606130.1\|4214186_4215797_-	hypothetical protein	NA	NA	NA	NA
WP_002606131.1\|4216019_4218182_+	DUF4135 domain-containing protein	NA	NA	NA	NA
WP_002606132.1\|4218188_4218896_-	LytTR family transcriptional regulator	NA	NA	NA	NA
WP_002606133.1\|4219028_4220366_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_002606134.1\|4220356_4221106_-	response regulator transcription factor	NA	NA	NA	NA
WP_002606135.1\|4221373_4222357_+	hypothetical protein	NA	NA	NA	NA
WP_002606136.1\|4222764_4223202_+	LytTR family transcriptional regulator	NA	NA	NA	NA
WP_002606137.1\|4223423_4223879_-	hypothetical protein	NA	NA	NA	NA
WP_002606138.1\|4223875_4225003_-	hypothetical protein	NA	NA	NA	NA
WP_002606139.1\|4224999_4225857_-	hypothetical protein	NA	NA	NA	NA
WP_002606140.1\|4225860_4227513_-	hypothetical protein	NA	NA	NA	NA
WP_009588252.1\|4227881_4228073_+	hypothetical protein	NA	NA	NA	NA
WP_002606142.1\|4229609_4230155_-	M23 family metallopeptidase	A0A0E3XDN6	Enterococcus_phage	3.9e-25	37.7
WP_002606143.1\|4230303_4230621_-	hypothetical protein	NA	NA	NA	NA
WP_081615980.1\|4231012_4231180_+\|transposase	transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP048838

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection