CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP022557	Geobacillus subterraneus strain E55-1	35 crisprs	cas3,DinG,csa3,DEDDh,cmr6gr7,cmr5gr11,cmr4gr7,csm6,cmr3gr5,cas10,cmr1gr7,csx1,cas14j,cas8b1,cas7,cas5,cas4,cas1,cas2,cas6,cas9,cas14k	9	25	8	4
NZ_AP022559	Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence	0 crisprs	NA	0	0	1	0
NZ_AP022558	Geobacillus subterraneus strain E55-1 plasmid pGspE55-1, complete sequence	0 crisprs	NA	0	0	11	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP022557_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_1

359706-359792

Orphan

Consensus_repeat	Method
AGATGGGGAAAACAACGCCATATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_1

>merge|NZ_AP022557|1|359706-359792|CRISPRCasFinder
AGATGGGGAAAACAACGCCATATCAAATTATGAGCCAAAAAAATATCGGCGCGCTTCCGGTTGAGATGGGGAAAACAACGCCATATC

>NZ_AP022557|1|1|359706-359792|CRISPRCasFinder
AGATGGGGAAAACAACGCCATATC	AAATTATGAGCCAAAAAAATATCGGCGCGCTTCCGGTTG
AGATGGGGAAAACAACGCCATATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033018020.1\|357311_358025_+\|RNA-polymerase-sporulation-sigma-factor-SigK	unknown	unknown	gnl\|CDD\|180266
NZ_AP022557.1\|WP_061912323.1\|353837_354764_+\|cysteine-synthase-family-protein	unknown	unknown	gnl\|CDD\|107204
NZ_AP022557.1\|WP_033844202.1\|361931_362714_-\|flagellar-motor-protein-MotB	unknown	unknown	gnl\|CDD\|236080
NZ_AP022557.1\|WP_061912325.1\|352441_353089_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_AP022557.1\|WP_033019286.1\|359881_360475_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_AP022557.1\|WP_061912324.1\|353104_353809_+\|5'-methylthioadenosine/S-adenosylhomocysteine-nucleosidase	unknown	unknown	gnl\|CDD\|180148
NZ_AP022557.1\|WP_061912326.1\|352039_352249_-\|YrzA-family-protein	unknown	unknown	gnl\|CDD\|371221
NZ_AP022557.1\|WP_033844204.1\|360577_361603_+\|sporulation-integral-membrane-protein-YtvI	unknown	unknown	gnl\|CDD\|274334
NZ_AP022557.1\|WP_033019279.1\|362706_363507_-\|flagellar-motor-stator-protein-MotA	unknown	unknown	gnl\|CDD\|181238
NZ_AP022557.1\|WP_061912321.1\|355958_356207_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372926
NZ_AP022557.1\|WP_033844201.1\|366312_366828_+\|YqeG-family-HAD-IIIA-type-phosphatase	unknown	unknown	gnl\|CDD\|225090
NZ_AP022557.1\|WP_081897239.1\|356697_356841_+\|YrzI-family-small-protein	unknown	unknown	gnl\|CDD\|312864
NZ_AP022557.1\|WP_033844200.1\|367962_368793_+\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|234703
NZ_AP022557.1\|WP_008879941.1\|365833_365974_-\|sporulation-histidine-kinase-inhibitor-Sda	unknown	unknown	gnl\|CDD\|370219
NZ_AP022557.1\|WP_172418477.1\|351341_351968_+\|YrrS-family-protein	unknown	unknown	gnl\|CDD\|377832
NZ_AP022557.1\|WP_051962724.1\|364341_365181_+\|phosphatidylserine-decarboxylase	unknown	unknown	gnl\|CDD\|179544
NZ_AP022557.1\|WP_033019277.1\|363677_364217_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|224104
NZ_AP022557.1\|WP_061912322.1\|354763_355897_+\|bifunctional-cystathionine-gamma-lyase/homocysteine-desulfhydrase	unknown	unknown	gnl\|CDD\|181076
NZ_AP022557.1\|WP_061912319.1\|358319_359588_+\|glutamate/aspartate:proton-symporter-GltP	unknown	unknown	gnl\|CDD\|183075
NZ_AP022557.1\|WP_033844969.1\|366830_367940_+\|ribosome-biogenesis-GTPase-YqeH	unknown	unknown	gnl\|CDD\|237511

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033018020.1\|357311_358025_+\|RNA-polymerase-sporulation-sigma-factor-SigK	gnl\|CDD\|180266	PRK05803, PRK05803, RNA polymerase sporulation sigma factor SigK.	7.16143e-145
NZ_AP022557.1\|WP_061912323.1\|353837_354764_+\|cysteine-synthase-family-protein	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	5.57316e-151
NZ_AP022557.1\|WP_033844202.1\|361931_362714_-\|flagellar-motor-protein-MotB	gnl\|CDD\|236080	PRK07734, motB, flagellar motor protein MotB; Reviewed.	7.17632e-164
NZ_AP022557.1\|WP_061912325.1\|352441_353089_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	2.9291e-20
NZ_AP022557.1\|WP_033019286.1\|359881_360475_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	5.09669e-37
NZ_AP022557.1\|WP_061912324.1\|353104_353809_+\|5'-methylthioadenosine/S-adenosylhomocysteine-nucleosidase	gnl\|CDD\|180148	PRK05584, PRK05584, 5'-methylthioadenosine/adenosylhomocysteine nucleosidase.	5.53452e-125
NZ_AP022557.1\|WP_061912326.1\|352039_352249_-\|YrzA-family-protein	gnl\|CDD\|371221	pfam10750, DUF2536, Protein of unknown function (DUF2536). This family of proteins with unknown function appears to be restricted to Bacillus spp. Structural modelling suggests this domain may bind nucleic acids.	3.1362e-30
NZ_AP022557.1\|WP_033844204.1\|360577_361603_+\|sporulation-integral-membrane-protein-YtvI	gnl\|CDD\|274334	TIGR02872, UPF0118_membrane_protein_YtvI, sporulation integral membrane protein YtvI. Three lines of evidence show this protein to be involved in sporulation. First, it is under control of a sporulation-specific sigma factor, sigma-E. Second, mutation leads to a sporulation defect. Third, it if found in exactly those genomes whose bacteria are capable of sporulation, except for being absent in Clostridium acetobutylicum ATCC824. This protein has extensive hydrophobic regions and is likely an integral membrane protein. [Cellular processes, Sporulation and germination].	3.52797e-100
NZ_AP022557.1\|WP_033019279.1\|362706_363507_-\|flagellar-motor-stator-protein-MotA	gnl\|CDD\|181238	PRK08124, PRK08124, flagellar motor protein MotA; Validated.	1.32882e-169
NZ_AP022557.1\|WP_061912321.1\|355958_356207_+\|hypothetical-protein	gnl\|CDD\|372926	pfam14143, YrhC, YrhC-like protein. The YrhC-like protein family includes the B. subtilis YrhC protein, which is functionally uncharacterized. YrhC is on the same operon as the MccA and MccB genes, which are involved in the conversion of methionine to cysteine. Expression of this operon is repressed in the presence of sulphate or cysteine. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	9.5038e-25
NZ_AP022557.1\|WP_033844201.1\|366312_366828_+\|YqeG-family-HAD-IIIA-type-phosphatase	gnl\|CDD\|225090	COG2179, COG2179, Predicted hydrolase of the HAD superfamily [General function prediction only].	7.48632e-79
NZ_AP022557.1\|WP_081897239.1\|356697_356841_+\|YrzI-family-small-protein	gnl\|CDD\|312864	pfam09501, Bac_small_YrzI, Probable sporulation protein (Bac_small_yrzI). Members of this family are very small proteins, about 47 residues each, in the genus Bacillus. Single members are found in Bacillus subtilis and Bacillus halodurans, while arrays of six members in tandem are found in Bacillus cereus and Bacillus anthracis. An EIxxE motif present in most members of this family resembles cleavage sites by the germination protease GPR in a number of small acid-soluble spore proteins (SASP). A role in sporulation is possible.	1.56048e-05
NZ_AP022557.1\|WP_033844200.1\|367962_368793_+\|shikimate-dehydrogenase	gnl\|CDD\|234703	PRK00258, aroE, shikimate 5-dehydrogenase; Reviewed.	1.44397e-129
NZ_AP022557.1\|WP_008879941.1\|365833_365974_-\|sporulation-histidine-kinase-inhibitor-Sda	gnl\|CDD\|370219	pfam08970, Sda, Sporulation inhibitor A. Members of this protein family contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilized by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A).	4.22332e-16
NZ_AP022557.1\|WP_172418477.1\|351341_351968_+\|YrrS-family-protein	gnl\|CDD\|377832	pfam07423, DUF1510, Protein of unknown function (DUF1510). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown.	2.14844e-47
NZ_AP022557.1\|WP_051962724.1\|364341_365181_+\|phosphatidylserine-decarboxylase	gnl\|CDD\|179544	PRK03140, PRK03140, phosphatidylserine decarboxylase; Provisional.	6.99512e-176
NZ_AP022557.1\|WP_033019277.1\|363677_364217_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	gnl\|CDD\|224104	COG1183, PssA, Phosphatidylserine synthase [Lipid metabolism].	3.07116e-41
NZ_AP022557.1\|WP_061912322.1\|354763_355897_+\|bifunctional-cystathionine-gamma-lyase/homocysteine-desulfhydrase	gnl\|CDD\|181076	PRK07671, PRK07671, bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase.	0
NZ_AP022557.1\|WP_061912319.1\|358319_359588_+\|glutamate/aspartate:proton-symporter-GltP	gnl\|CDD\|183075	PRK11283, gltP, glutamate/aspartate:proton symporter; Provisional.	0
NZ_AP022557.1\|WP_033844969.1\|366830_367940_+\|ribosome-biogenesis-GTPase-YqeH	gnl\|CDD\|237511	PRK13796, PRK13796, GTPase YqeH; Provisional.	0

>NZ_AP022557.1|WP_061912319.1|358319_359588_+|glutamate/aspartate:proton-symporter-GltP
MKKIGLAWQIFIGLILGIVVGALFYGNPKVAVYLQPIGDIFLRLIKMIVIPIVVSSLIVGVANVGDVKKLGKLGVKTIIYFEIITTIAIVVGLLAANIFQPGTGVNMKSLEKTDIQSYIDTTNEVQHHSMAETFVNIVPKNVFEALSTGNMLPIIFFSVMFGLGVAAIGEKGQPVLRFFQGTAEAMFYVTNQIMKFAPFGVFALIGMTVSKFGVASLQPLSKLVILVYAVMAFFVVVVLGITAKLVGINIFHIIKILKDELVLAYSTSSSETVLPKIMEKMEKFGCPKAVTSFVIPTGYSFNLDGSTLYQALAAIFIAQLYGIDMPLSQQISLVLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPVEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSKWEGQYDEEKGKRYMAELQKQSA
>NZ_AP022557.1|WP_033018020.1|357311_358025_+|RNA-polymerase-sporulation-sigma-factor-SigK
MSGIVSVFAFLLKELTFLVSYIKNNAFPQPLSAKEEENYLALMAKGDEQARNRLIEHNLRLVAHIVKKFENTGEEVDDLISIGTIGLIKAIESYSPGKGTKLATYAARCIENEILMHLRSLKKTRKDVSLHEPIGQDKEGNEISLLDILKSEGQDIADEIQLNMEIEQVKKYIEVLDEREKEVIISRFGLGRQREKTQREIAKELGISRSYVSRIEKRALMKMFHEFYRQEKEKRRT
>NZ_AP022557.1|WP_081897239.1|356697_356841_+|YrzI-family-small-protein
MTIHLFFVTITIERKAPRRRNIEQERLRRAAEEELLDRKCSVHHRLF
>NZ_AP022557.1|WP_061912321.1|355958_356207_+|hypothetical-protein
MTERQRNELRAKAGDFTMYSLVLFALGAFLYLGAIIPGALAAADKPFALLAVAGCLAAALYCSRRAARYRHQLEEQDNPFES
>NZ_AP022557.1|WP_061912322.1|354763_355897_+|bifunctional-cystathionine-gamma-lyase/homocysteine-desulfhydrase
MRRKTLLIHGGIPGDPHTGAVSVPIYQVSTYKQEEIGKHKGFEYSRTGNPTRAALEKLIAELEGGVAGFAFASGMAAITAVMMLFDSGDHIVITDDVYGGTYRVMANVFNRFGLDATFVDTSDVANIEAHIRPNTKAIYVETPTNPLLKITDLQAAAAIARAHGLLLIVDNTFSTPYFQTPLELGADIVIHSATKYLGGHSDVVAGLAVVRTAELAERLHYVQNSTGGILGPQDSWLLMRGIKTLGVRMEEHEQNARAIAAFLAEHQAVARVYYPGLPEHPNYELAKTQMRGFGGMISFDVGSLERAETVLSRVRFFTLAESLGAVESLISLPAKMTHASIPKERREQRGITDGLIRLSIGLEDVNDLLDDLAQALG
>NZ_AP022557.1|WP_061912323.1|353837_354764_+|cysteine-synthase-family-protein
MQVAKSIHELIGRTPLVEITRFPLPEGVRLFAKLEYFNPGGSIKDRLGQELLREAFESGKLKEGGTIIEPTAGNTGIGLALAAIDKNINVIFCVPEKFSIEKQQLMKALGAQIVHTPTEEGMEGAIRKAEELARTIPGAYCPQQFRNPANPRTYYKTLGPELWDDLDGQIDIFVAGAGSGGTFMGTATFLKEKNPAIKTVIVEPEGSILGGGEPGPHRTEGIGMEFLPPFLDPAYFDAIYTIADDDAFRRVSELARQEGLLVGSSSGAAFHAALLEAEKAKPGTNIAVIFPDSSERYLSKNIYEGGGS
>NZ_AP022557.1|WP_061912324.1|353104_353809_+|5'-methylthioadenosine/S-adenosylhomocysteine-nucleosidase
MKAAIIGAMEEEVAMLRARMEGREDTAIAGCEFSAGRLNGVEAVLLKSGIGKVNAAMGTTLLLDRFRPDVVINTGSAGGFLPSLRVGDLVISEEVVHHDVDVTAFGYAYGQVPGLPARYRADETLVEAAKQAATQLNGLQAAVGLIATGDSFMNDPKRVEFVRGQFPELCAVEMEAAAIAQVCVQFGVPFVVIRALSDIAGQESDVSFEQFLETAAKHSAELVLSMLSILSARS
>NZ_AP022557.1|WP_061912325.1|352441_353089_+|class-I-SAM-dependent-methyltransferase
MGREFLDLFEQWAESYDQSVEGHDEQYRDVFAGYGRILDAVADKAGQVVLEFGVGTGNLTKKLLERGKTVYGIEPSAPMRKKALEKLGGRAVIMDGDFLRFPLPSEPIDTVASTYAFHHLTDAEKGEAIAKYSQLLRPGGKIVFADTAFRDKAAFRRAVEAARARGFHDLADDLEREYYTTLDVLAALFATHGFSASFTQQNAFVWLMEAVKQID
>NZ_AP022557.1|WP_061912326.1|352039_352249_-|YrzA-family-protein
MVNISLDLIEDKIEFFEADDLRTLEKKINEQIEHNKALLLSVHHVAHQMHVMENGNRFYSAVVHFKAKK
>NZ_AP022557.1|WP_172418477.1|351341_351968_+|YrrS-family-protein
MAQTETRFAARAKRRKMNRWLNGAIAVVLLLIVMVAWNLLFGGKADQQTAGKTKRTEVETGAAVVSNEEKKPAAGSDTAGGETEETAETNEEESTKVTETPGPPGSNIEKEIVNPAWQPVGTTQSEPHETVFDENSVDWKEMLDAVSYATGIAPEEMIVWFIGNNGPNKAVATISTKGQTAHYRVYIEWVTNEGWKPTKVQKLKQRPS
>NZ_AP022557.1|WP_033019286.1|359881_360475_+|DedA-family-protein
MHEAIQSLFSFLVGLGYAGIALALMVEVIPSEIVLAYAGYLVARGEITFAGAVAAGTFGGAVAQLFLYWMGVYGGRPFLDRYGKYIGIQKKHLDVAERWFAKFGPGVIFSARFIPVVRHAISIPAGIARMKWLPFLIYTVLAIVPWSILFIWLGEQLGRRWRQIDEMAAPYVQPAIAAAAVATVIYIVWKWRRRAAE
>NZ_AP022557.1|WP_033844204.1|360577_361603_+|sporulation-integral-membrane-protein-YtvI
MKRWLLIVLLLAVGIWLVPYSVPLLLALATALLLEPSIRRLQQTYRLKRVHAVTAIFSLFIVIVGVLLYVLIVIFVEQVMALSQKLPAFLSEATKVLDRLIQTWQSYSSSIPREIIESLERGVNTVQQMLLSFASSLTQSLVHYIAAVPAFLIHFLVYIVALFLICLDLPRLKQGVRRHLSERTEQRLGMIVTQLSKAAVGFIKAQFLLSVITFFLALAGLVVLGIDYAALMALVIVIVDILPILGTGSVLVPWGIISIANGDKALGIGLIVLFVVITVVRRIIEPKVFSTNLGISPLAALVSVYLGFQLLGFIGLFVGPVVVILVEALAKAGVIRWTIKL
>NZ_AP022557.1|WP_033844202.1|361931_362714_-|flagellar-motor-protein-MotB
MANKKKKGGHEEHINESWLIPYADLLTLLLALFIVLFASSQIDQKKFQEIARSFNTAFAGGTGVLDFQSPVQPIAPPDQNEKGQERPSSPSRSVSGQEKEELAEIKAKIDAYIRQNELGGKLQTSLDDEGLAITILDDILFDSGSADVRIKDRRLAAEISKLLVMNPPRDIIISGHTDNVPIHNAQFASNWELSVMRAVNFMKVLLENKQLDPRRFSAKGYGEYKPIASNATAAGRMKNRRVEILILPRSDTSPSSASAR
>NZ_AP022557.1|WP_033019279.1|362706_363507_-|flagellar-motor-stator-protein-MotA
MDKTSIIGLILGIIGIGLGMYFKGVSPAVLINPAAILIILVGTAAAVTIAFPTREIKKVPKLLKIIFTESSTPTVEQLIPLFVEWANIARREGLLALEAKLDDVDDPFLRNGLSMAIDGQTQEFIRDVMTEEVAAMEERHEANAAIFTQAGTYAPTLGVLGAVIGLIAALGNLENIAELGHAISAAFVATMLGIFTGYVLWHPFANKLRRKSKEEAKVRYIMIEGVLSILEGQAPRTIEQKLASYLSESEREHLIEPQNEGEAVNG
>NZ_AP022557.1|WP_033019277.1|363677_364217_-|CDP-diacylglycerol--serine-O-phosphatidyltransferase
MFLSDYLDYTLKKLKANVANILTLTNLSLGGFSVLATLKGQLHMSVLLIFLAAFVDRFDGAVARRLNIESELGKQLDSMSDIISFGVAPALLMYQGLFHEFGAPGAVFTILYVACGAFRLARFNITENNGYFSGLPITAAGVLMTLGYLAIPYVPPQSFMFLALMLSFLMVGTFKLKKI
>NZ_AP022557.1|WP_051962724.1|364341_365181_+|phosphatidylserine-decarboxylase
MRKWLYRLFIELTNHWLSSKLLASFAKSRLSALLIPSYAKVYHINQEEMEKSLKNYKTLQQLFIRRLKAGTRPIDADERAVVSPVDAVIEAMGIIEEPWEMTVKGKRYSIAEMLGGEEAAQPYVNGFFFILYLSPSHYHRIHSPISGVIEKQWTLGRKSYPVNRLGLKYGRRPLEKNYRLITEVKADGKRLAIVKIGAMFVNSIELTHEGDQLIKGEEMAYFSFGSTVVLLFERGSFTPDPNVAAPMPIKVGERLGYWCQQSDGKGNEGGRGRRNLSTL
>NZ_AP022557.1|WP_008879941.1|365833_365974_-|sporulation-histidine-kinase-inhibitor-Sda
MKHLSDELLIESYFKAKELNLSPEFIELIEKEIQRRSLTHKIKLSS
>NZ_AP022557.1|WP_033844201.1|366312_366828_+|YqeG-family-HAD-IIIA-type-phosphatase
MLHYFLPSQFVKRVIDIAPDELKEKGVKGIITDLDNTLVEWDRPSATPELAAWFDAMKQAGIKVVIVSNNNKRRVQSFAEPLGIPFIFEARKPLTRAFLRALHMMGLNKEEVVVIGDQLLTDVLGGNRLGLNTILVVPVSETDGWWTRFNRKMERRILNAMRKKGMIYWEE
>NZ_AP022557.1|WP_033844969.1|366830_367940_+|ribosome-biogenesis-GTPase-YqeH
MEPQLRCIGCGAAIQVEDPKKAGYAPKSVLEKEAEGIVCQRCFRLKHYNEVQDVPLDDSDFVNMLHRIGESKALVVYIVDIFDFNGSWIPGLPRFAADNPILLVGNKADLLPRSVNYLKLVQWMRRMAEELGLRPVDVCLVSAAKGIGMGKVMEAMERFRKGGDVYVVGCTNVGKSTFINRVIEEATGKGNVITTSYFPGTTLDMIEIPLEGGSSLYDTPGIINHHQMAHFVDARDLKIITPKREIHPRVYQLNEGQTLFFGGLARLDYVKGGRRSFVCYMANELTIHRTKREKADSLYASQLGQLLSPPNKRYAADFPPLVPRTLSVKERKTDIVFSGLGWVTCNDPGAQLVVYAPKGVDVLIRQSLI
>NZ_AP022557.1|WP_033844200.1|367962_368793_+|shikimate-dehydrogenase
MENVYGLFGFPVEHSLSPLMHNDAFACLGIPARYHLFPVKPGQVGAALAGVRALGIAGVNVTIPHKMAVMPFLDEIDDHARRIGAVNTIVNRDGRLVGYNTDGPGYVRALEEELDVSFAGKRILVIGAGGGARGIYFSLLSTAAARIDMANRTIEKAAQLVGEGKDDRSAFFSLAEAEKRLAEYDIVINTTAAGMHPQEEEQPLSLERLRPGTIVSDIIYNPLETKWLKEAKARGARTQNGVGMLVYQGALAFEKWTGQWPDVKRMKQLVIEALRR

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Crispr_ID: NZ_AP022557_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_2

365316-365410

TypeV-U4

Consensus_repeat	Method
CACGGTAAGTTCCGTGGGCAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_2

>merge|NZ_AP022557|2|365316-365410|CRISPRCasFinder
CACGGTAAGTTCCGTGGGCAGCGGTCTTCCCTTCCCCCGGGGATAAGCGTCTAGCGTGAGTTTGGCATTGTTCACGGCAAGTTCCGTGGGCAGCG

>NZ_AP022557|2|2|365316-365410|CRISPRCasFinder
CACGGTAAGTTCCGTGGGCAGCG	GTCTTCCCTTCCCCCGGGGATAAGCGTCTAGCGTGAGTTTGGCATTGTT
CACGGCAAGTTCCGTGGGCAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033844204.1\|360577_361603_+\|sporulation-integral-membrane-protein-YtvI	unknown	unknown	gnl\|CDD\|274334
NZ_AP022557.1\|WP_033844967.1\|370408_370765_+\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|223870
NZ_AP022557.1\|WP_033844197.1\|369833_370403_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224627
NZ_AP022557.1\|WP_033844198.1\|369274_369925_+\|nicotinate-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
NZ_AP022557.1\|WP_033844200.1\|367962_368793_+\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|234703
NZ_AP022557.1\|WP_033019277.1\|363677_364217_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|224104
NZ_AP022557.1\|WP_033019286.1\|359881_360475_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_AP022557.1\|WP_033844199.1\|368796_369090_+\|ribosome-assembly-RNA-binding-protein-YhbY	unknown	unknown	gnl\|CDD\|224451
NZ_AP022557.1\|WP_033018020.1\|357311_358025_+\|RNA-polymerase-sporulation-sigma-factor-SigK	unknown	unknown	gnl\|CDD\|180266
NZ_AP022557.1\|WP_033019279.1\|362706_363507_-\|flagellar-motor-stator-protein-MotA	unknown	unknown	gnl\|CDD\|181238
NZ_AP022557.1\|WP_061912321.1\|355958_356207_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372926
NZ_AP022557.1\|WP_033844202.1\|361931_362714_-\|flagellar-motor-protein-MotB	unknown	unknown	gnl\|CDD\|236080
NZ_AP022557.1\|WP_033844195.1\|372098_373217_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226957
NZ_AP022557.1\|WP_061912319.1\|358319_359588_+\|glutamate/aspartate:proton-symporter-GltP	unknown	unknown	gnl\|CDD\|183075
NZ_AP022557.1\|WP_008879941.1\|365833_365974_-\|sporulation-histidine-kinase-inhibitor-Sda	unknown	unknown	gnl\|CDD\|370219
NZ_AP022557.1\|WP_033844201.1\|366312_366828_+\|YqeG-family-HAD-IIIA-type-phosphatase	unknown	unknown	gnl\|CDD\|225090
NZ_AP022557.1\|WP_051962724.1\|364341_365181_+\|phosphatidylserine-decarboxylase	unknown	unknown	gnl\|CDD\|179544
NZ_AP022557.1\|WP_033844196.1\|370761_371505_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_AP022557.1\|WP_081897239.1\|356697_356841_+\|YrzI-family-small-protein	unknown	unknown	gnl\|CDD\|312864
NZ_AP022557.1\|WP_033844969.1\|366830_367940_+\|ribosome-biogenesis-GTPase-YqeH	unknown	unknown	gnl\|CDD\|237511

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033844204.1\|360577_361603_+\|sporulation-integral-membrane-protein-YtvI	gnl\|CDD\|274334	TIGR02872, UPF0118_membrane_protein_YtvI, sporulation integral membrane protein YtvI. Three lines of evidence show this protein to be involved in sporulation. First, it is under control of a sporulation-specific sigma factor, sigma-E. Second, mutation leads to a sporulation defect. Third, it if found in exactly those genomes whose bacteria are capable of sporulation, except for being absent in Clostridium acetobutylicum ATCC824. This protein has extensive hydrophobic regions and is likely an integral membrane protein. [Cellular processes, Sporulation and germination].	3.52797e-100
NZ_AP022557.1\|WP_033844967.1\|370408_370765_+\|ribosome-silencing-factor	gnl\|CDD\|223870	COG0799, COG0799, Uncharacterized homolog of plant Iojap protein [Function unknown].	5.88936e-49
NZ_AP022557.1\|WP_033844197.1\|369833_370403_+\|HD-domain-containing-protein	gnl\|CDD\|224627	COG1713, COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism].	1.56391e-80
NZ_AP022557.1\|WP_033844198.1\|369274_369925_+\|nicotinate-nucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	5.83005e-97
NZ_AP022557.1\|WP_033844200.1\|367962_368793_+\|shikimate-dehydrogenase	gnl\|CDD\|234703	PRK00258, aroE, shikimate 5-dehydrogenase; Reviewed.	1.44397e-129
NZ_AP022557.1\|WP_033019277.1\|363677_364217_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	gnl\|CDD\|224104	COG1183, PssA, Phosphatidylserine synthase [Lipid metabolism].	3.07116e-41
NZ_AP022557.1\|WP_033019286.1\|359881_360475_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	5.09669e-37
NZ_AP022557.1\|WP_033844199.1\|368796_369090_+\|ribosome-assembly-RNA-binding-protein-YhbY	gnl\|CDD\|224451	COG1534, COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis].	4.21726e-43
NZ_AP022557.1\|WP_033018020.1\|357311_358025_+\|RNA-polymerase-sporulation-sigma-factor-SigK	gnl\|CDD\|180266	PRK05803, PRK05803, RNA polymerase sporulation sigma factor SigK.	7.16143e-145
NZ_AP022557.1\|WP_033019279.1\|362706_363507_-\|flagellar-motor-stator-protein-MotA	gnl\|CDD\|181238	PRK08124, PRK08124, flagellar motor protein MotA; Validated.	1.32882e-169
NZ_AP022557.1\|WP_061912321.1\|355958_356207_+\|hypothetical-protein	gnl\|CDD\|372926	pfam14143, YrhC, YrhC-like protein. The YrhC-like protein family includes the B. subtilis YrhC protein, which is functionally uncharacterized. YrhC is on the same operon as the MccA and MccB genes, which are involved in the conversion of methionine to cysteine. Expression of this operon is repressed in the presence of sulphate or cysteine. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	9.5038e-25
NZ_AP022557.1\|WP_033844202.1\|361931_362714_-\|flagellar-motor-protein-MotB	gnl\|CDD\|236080	PRK07734, motB, flagellar motor protein MotB; Reviewed.	7.17632e-164
NZ_AP022557.1\|WP_033844195.1\|372098_373217_+\|ABC-transporter-permease	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	1.26541e-10
NZ_AP022557.1\|WP_061912319.1\|358319_359588_+\|glutamate/aspartate:proton-symporter-GltP	gnl\|CDD\|183075	PRK11283, gltP, glutamate/aspartate:proton symporter; Provisional.	0
NZ_AP022557.1\|WP_008879941.1\|365833_365974_-\|sporulation-histidine-kinase-inhibitor-Sda	gnl\|CDD\|370219	pfam08970, Sda, Sporulation inhibitor A. Members of this protein family contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilized by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A).	4.22332e-16
NZ_AP022557.1\|WP_033844201.1\|366312_366828_+\|YqeG-family-HAD-IIIA-type-phosphatase	gnl\|CDD\|225090	COG2179, COG2179, Predicted hydrolase of the HAD superfamily [General function prediction only].	7.48632e-79
NZ_AP022557.1\|WP_051962724.1\|364341_365181_+\|phosphatidylserine-decarboxylase	gnl\|CDD\|179544	PRK03140, PRK03140, phosphatidylserine decarboxylase; Provisional.	6.99512e-176
NZ_AP022557.1\|WP_033844196.1\|370761_371505_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	2.48343e-17
NZ_AP022557.1\|WP_081897239.1\|356697_356841_+\|YrzI-family-small-protein	gnl\|CDD\|312864	pfam09501, Bac_small_YrzI, Probable sporulation protein (Bac_small_yrzI). Members of this family are very small proteins, about 47 residues each, in the genus Bacillus. Single members are found in Bacillus subtilis and Bacillus halodurans, while arrays of six members in tandem are found in Bacillus cereus and Bacillus anthracis. An EIxxE motif present in most members of this family resembles cleavage sites by the germination protease GPR in a number of small acid-soluble spore proteins (SASP). A role in sporulation is possible.	1.56048e-05
NZ_AP022557.1\|WP_033844969.1\|366830_367940_+\|ribosome-biogenesis-GTPase-YqeH	gnl\|CDD\|237511	PRK13796, PRK13796, GTPase YqeH; Provisional.	0

>NZ_AP022557.1|WP_051962724.1|364341_365181_+|phosphatidylserine-decarboxylase
MRKWLYRLFIELTNHWLSSKLLASFAKSRLSALLIPSYAKVYHINQEEMEKSLKNYKTLQQLFIRRLKAGTRPIDADERAVVSPVDAVIEAMGIIEEPWEMTVKGKRYSIAEMLGGEEAAQPYVNGFFFILYLSPSHYHRIHSPISGVIEKQWTLGRKSYPVNRLGLKYGRRPLEKNYRLITEVKADGKRLAIVKIGAMFVNSIELTHEGDQLIKGEEMAYFSFGSTVVLLFERGSFTPDPNVAAPMPIKVGERLGYWCQQSDGKGNEGGRGRRNLSTL
>NZ_AP022557.1|WP_033019277.1|363677_364217_-|CDP-diacylglycerol--serine-O-phosphatidyltransferase
MFLSDYLDYTLKKLKANVANILTLTNLSLGGFSVLATLKGQLHMSVLLIFLAAFVDRFDGAVARRLNIESELGKQLDSMSDIISFGVAPALLMYQGLFHEFGAPGAVFTILYVACGAFRLARFNITENNGYFSGLPITAAGVLMTLGYLAIPYVPPQSFMFLALMLSFLMVGTFKLKKI
>NZ_AP022557.1|WP_033019279.1|362706_363507_-|flagellar-motor-stator-protein-MotA
MDKTSIIGLILGIIGIGLGMYFKGVSPAVLINPAAILIILVGTAAAVTIAFPTREIKKVPKLLKIIFTESSTPTVEQLIPLFVEWANIARREGLLALEAKLDDVDDPFLRNGLSMAIDGQTQEFIRDVMTEEVAAMEERHEANAAIFTQAGTYAPTLGVLGAVIGLIAALGNLENIAELGHAISAAFVATMLGIFTGYVLWHPFANKLRRKSKEEAKVRYIMIEGVLSILEGQAPRTIEQKLASYLSESEREHLIEPQNEGEAVNG
>NZ_AP022557.1|WP_033844202.1|361931_362714_-|flagellar-motor-protein-MotB
MANKKKKGGHEEHINESWLIPYADLLTLLLALFIVLFASSQIDQKKFQEIARSFNTAFAGGTGVLDFQSPVQPIAPPDQNEKGQERPSSPSRSVSGQEKEELAEIKAKIDAYIRQNELGGKLQTSLDDEGLAITILDDILFDSGSADVRIKDRRLAAEISKLLVMNPPRDIIISGHTDNVPIHNAQFASNWELSVMRAVNFMKVLLENKQLDPRRFSAKGYGEYKPIASNATAAGRMKNRRVEILILPRSDTSPSSASAR
>NZ_AP022557.1|WP_033844204.1|360577_361603_+|sporulation-integral-membrane-protein-YtvI
MKRWLLIVLLLAVGIWLVPYSVPLLLALATALLLEPSIRRLQQTYRLKRVHAVTAIFSLFIVIVGVLLYVLIVIFVEQVMALSQKLPAFLSEATKVLDRLIQTWQSYSSSIPREIIESLERGVNTVQQMLLSFASSLTQSLVHYIAAVPAFLIHFLVYIVALFLICLDLPRLKQGVRRHLSERTEQRLGMIVTQLSKAAVGFIKAQFLLSVITFFLALAGLVVLGIDYAALMALVIVIVDILPILGTGSVLVPWGIISIANGDKALGIGLIVLFVVITVVRRIIEPKVFSTNLGISPLAALVSVYLGFQLLGFIGLFVGPVVVILVEALAKAGVIRWTIKL
>NZ_AP022557.1|WP_033019286.1|359881_360475_+|DedA-family-protein
MHEAIQSLFSFLVGLGYAGIALALMVEVIPSEIVLAYAGYLVARGEITFAGAVAAGTFGGAVAQLFLYWMGVYGGRPFLDRYGKYIGIQKKHLDVAERWFAKFGPGVIFSARFIPVVRHAISIPAGIARMKWLPFLIYTVLAIVPWSILFIWLGEQLGRRWRQIDEMAAPYVQPAIAAAAVATVIYIVWKWRRRAAE
>NZ_AP022557.1|WP_061912319.1|358319_359588_+|glutamate/aspartate:proton-symporter-GltP
MKKIGLAWQIFIGLILGIVVGALFYGNPKVAVYLQPIGDIFLRLIKMIVIPIVVSSLIVGVANVGDVKKLGKLGVKTIIYFEIITTIAIVVGLLAANIFQPGTGVNMKSLEKTDIQSYIDTTNEVQHHSMAETFVNIVPKNVFEALSTGNMLPIIFFSVMFGLGVAAIGEKGQPVLRFFQGTAEAMFYVTNQIMKFAPFGVFALIGMTVSKFGVASLQPLSKLVILVYAVMAFFVVVVLGITAKLVGINIFHIIKILKDELVLAYSTSSSETVLPKIMEKMEKFGCPKAVTSFVIPTGYSFNLDGSTLYQALAAIFIAQLYGIDMPLSQQISLVLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPVEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSKWEGQYDEEKGKRYMAELQKQSA
>NZ_AP022557.1|WP_033018020.1|357311_358025_+|RNA-polymerase-sporulation-sigma-factor-SigK
MSGIVSVFAFLLKELTFLVSYIKNNAFPQPLSAKEEENYLALMAKGDEQARNRLIEHNLRLVAHIVKKFENTGEEVDDLISIGTIGLIKAIESYSPGKGTKLATYAARCIENEILMHLRSLKKTRKDVSLHEPIGQDKEGNEISLLDILKSEGQDIADEIQLNMEIEQVKKYIEVLDEREKEVIISRFGLGRQREKTQREIAKELGISRSYVSRIEKRALMKMFHEFYRQEKEKRRT
>NZ_AP022557.1|WP_081897239.1|356697_356841_+|YrzI-family-small-protein
MTIHLFFVTITIERKAPRRRNIEQERLRRAAEEELLDRKCSVHHRLF
>NZ_AP022557.1|WP_061912321.1|355958_356207_+|hypothetical-protein
MTERQRNELRAKAGDFTMYSLVLFALGAFLYLGAIIPGALAAADKPFALLAVAGCLAAALYCSRRAARYRHQLEEQDNPFES
>NZ_AP022557.1|WP_008879941.1|365833_365974_-|sporulation-histidine-kinase-inhibitor-Sda
MKHLSDELLIESYFKAKELNLSPEFIELIEKEIQRRSLTHKIKLSS
>NZ_AP022557.1|WP_033844201.1|366312_366828_+|YqeG-family-HAD-IIIA-type-phosphatase
MLHYFLPSQFVKRVIDIAPDELKEKGVKGIITDLDNTLVEWDRPSATPELAAWFDAMKQAGIKVVIVSNNNKRRVQSFAEPLGIPFIFEARKPLTRAFLRALHMMGLNKEEVVVIGDQLLTDVLGGNRLGLNTILVVPVSETDGWWTRFNRKMERRILNAMRKKGMIYWEE
>NZ_AP022557.1|WP_033844969.1|366830_367940_+|ribosome-biogenesis-GTPase-YqeH
MEPQLRCIGCGAAIQVEDPKKAGYAPKSVLEKEAEGIVCQRCFRLKHYNEVQDVPLDDSDFVNMLHRIGESKALVVYIVDIFDFNGSWIPGLPRFAADNPILLVGNKADLLPRSVNYLKLVQWMRRMAEELGLRPVDVCLVSAAKGIGMGKVMEAMERFRKGGDVYVVGCTNVGKSTFINRVIEEATGKGNVITTSYFPGTTLDMIEIPLEGGSSLYDTPGIINHHQMAHFVDARDLKIITPKREIHPRVYQLNEGQTLFFGGLARLDYVKGGRRSFVCYMANELTIHRTKREKADSLYASQLGQLLSPPNKRYAADFPPLVPRTLSVKERKTDIVFSGLGWVTCNDPGAQLVVYAPKGVDVLIRQSLI
>NZ_AP022557.1|WP_033844200.1|367962_368793_+|shikimate-dehydrogenase
MENVYGLFGFPVEHSLSPLMHNDAFACLGIPARYHLFPVKPGQVGAALAGVRALGIAGVNVTIPHKMAVMPFLDEIDDHARRIGAVNTIVNRDGRLVGYNTDGPGYVRALEEELDVSFAGKRILVIGAGGGARGIYFSLLSTAAARIDMANRTIEKAAQLVGEGKDDRSAFFSLAEAEKRLAEYDIVINTTAAGMHPQEEEQPLSLERLRPGTIVSDIIYNPLETKWLKEAKARGARTQNGVGMLVYQGALAFEKWTGQWPDVKRMKQLVIEALRR
>NZ_AP022557.1|WP_033844199.1|368796_369090_+|ribosome-assembly-RNA-binding-protein-YhbY
MLTGKQKRFLRAQAHHLKPIFQVGKGGVTEAMTEQIAAALEARELLKVSVLQNCEDDRDTVAEQLAAGTGAEIVQVIGNTIVLYKESNEHKRIVLPK
>NZ_AP022557.1|WP_033844198.1|369274_369925_+|nicotinate-nucleotide-adenylyltransferase
MRKIGILGGTFDPPHCGHLLMADEVLDALELSQIWFLPNRIPPHKQHEQVTRSEDRLRMLELAIAGHPRFRIETIELERKGPSYTYDTLRQLTAAHPDDEFYFIIGADMVEYLPNWHRIDELVQLVTFVGVKRPGFSLETPYPVIEVEAPQFAVSSSLIRERVRRGQTIRYLVPEAVRLYIEEKGLYGTGTSVANRETAADRDALRAHAWRCRDRR
>NZ_AP022557.1|WP_033844197.1|369833_370403_+|HD-domain-containing-protein
MEREQALQIVKQQLTETRYEHTLGVVATAVKLAKQYGADAKKAELAAIFHDYAKFRPVEEMKQIILAQNMPNDLLAYNSELWHAPVGAYLVQAEVGLDDPEVLDAIRYHTSGRAGMTLLEKIIYLADYIEPGRRFPGVDDVRRLAEEDLNRALWQAVKNTIAFLLEKRQLIYPDTIHAYNSLLREVKGE
>NZ_AP022557.1|WP_033844967.1|370408_370765_+|ribosome-silencing-factor
MNEQEALQLVVRAADDKKAENIVVLNMKGISLVADYFVICHGNSDKQVQAIAHEIQDQAEEHGLAVKRIEGFHEAKWVLVDLGDIVAHVFAKEERDYYGLERLWGDAPTEDVAAVLQP
>NZ_AP022557.1|WP_033844196.1|370761_371505_+|class-I-SAM-dependent-methyltransferase
MTYGRFADWYDVLMADAPYGEWQSFVERSFDRYARRPGRRVIDIGCGTGELAIRLAKDGWQVAGVDLSAQMLSIAQEKAEAAGVHVPLFEQNMAELDGFSDLDGALVFCDALNYLMNEEDVQTTFAAVSRALGAGGLLLFDVHSVYKMDVLFRDAVFADQGEDISYIWTCHPLDWPHSVGHELTFFVRRGDRYERFDEWHEQRTFEQAVYEQWLDAAGFEVLEVTADFTDAPPTETAERLFFVARKR
>NZ_AP022557.1|WP_033844195.1|372098_373217_+|ABC-transporter-permease
MIFSSIKNQIKAHPITTFFIVLGLSLSVLMISVGISSMNYSKLLEQEQEHYQPRHAVSVGITFAEEPNWQRVLGLFKNIHAQTGVILEEVTLSHGDAMMAVTPEYWTKKVVERFPLVEGRYFTINEIQEGKKVALVGKDRMKDVRVEGSDRYLTMGHDRYKVIGIIGVKGKRTRVIDYQVVIPMTSLPVAAINKLTSAKQLHFTIHNPVKDPYEDEKMIRQNMERLFPAAQMDVSPYTSNIMLHVDFGEQLALMIMIYLLAIVNAVNLTSYWIQERTYEIGIKKAFGYSNYDIVFMLFCEMCLISAVSVLIGFALQLLCNRMIEQWIDYPIHLSITHLSTAVVFVVLSAALTIIIPAMKAIRVQPVDVMNRR

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Crispr_ID: NZ_AP022557_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_3

459375-459460

Orphan

Consensus_repeat	Method
GTCTTTCCATGTTGCGGAGCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_3

>merge|NZ_AP022557|3|459375-459460|CRISPRCasFinder
GTCTTTCCATGTTGCGGAGCCGCAGGAGATCGTCATCGGTTCGGTCGTTTGCGAGACGGAAGTGTCTTTCCATGTTGCGCAGCCGC

>NZ_AP022557|3|3|459375-459460|CRISPRCasFinder
GTCTTTCCATGTTGCGGAGCCGC	AGGAGATCGTCATCGGTTCGGTCGTTTGCGAGACGGAAGT
GTCTTTCCATGTTGCGCAGCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033018999.1\|459112_459295_+\|YqzE-family-protein	unknown	unknown	gnl\|CDD\|372887
NZ_AP022557.1\|WP_033018997.1\|457882_458209_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225076
NZ_AP022557.1\|WP_033019007.1\|468550_469387_+\|lipoate--protein-ligase-family-protein	unknown	unknown	gnl\|CDD\|223173
NZ_AP022557.1\|WP_033844177.1\|453642_453885_-\|DUF2626-family-protein	unknown	unknown	gnl\|CDD\|378559
NZ_AP022557.1\|WP_033019000.1\|459468_460263_-\|YqhG-family-protein	unknown	unknown	gnl\|CDD\|371367
NZ_AP022557.1\|WP_033019002.1\|462405_463500_+\|glycine-cleavage-system-aminomethyltransferase-GcvT	unknown	unknown	gnl\|CDD\|234742
NZ_AP022557.1\|WP_033844174.1\|457455_457899_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|225076
NZ_AP022557.1\|WP_033018998.1\|458682_459072_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372946
NZ_AP022557.1\|WP_033018995.1\|457175_457472_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|226912
NZ_AP022557.1\|WP_082799286.1\|466656_467871_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_AP022557.1\|WP_061912159.1\|467984_468359_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_AP022557.1\|WP_081897237.1\|454819_455980_+\|type-II/IV-secretion-system-protein	unknown	unknown	gnl\|CDD\|225363
NZ_AP022557.1\|WP_108209741.1\|458145_458628_+\|ComGF-family-competence-protein	unknown	unknown	gnl\|CDD\|374268
NZ_AP022557.1\|WP_033844176.1\|454021_454711_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225222
NZ_AP022557.1\|WP_160331357.1\|471231_471555_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373112
NZ_AP022557.1\|WP_033844175.1\|455976_457005_+\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224376
NZ_AP022557.1\|WP_061912185.1\|464874_466347_+\|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPB	unknown	unknown	gnl\|CDD\|235292
NZ_AP022557.1\|WP_033019001.1\|460249_461914_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|350769
NZ_AP022557.1\|WP_172418485.1\|473535_474948_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|119353
NZ_AP022557.1\|WP_061912160.1\|463535_464882_+\|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPA	unknown	unknown	gnl\|CDD\|234769

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033018999.1\|459112_459295_+\|YqzE-family-protein	gnl\|CDD\|372887	pfam14038, YqzE, YqzE-like protein. The YqzE-like protein family includes the B. subtilis YqzE protein, which is functionally uncharacterized. It is a part of the ComG operon, which is regulated by the competence transcription factor ComK. This family of proteins is found in bacteria. Proteins in this family are typically between 49 and 66 amino acids in length.	1.06909e-23
NZ_AP022557.1\|WP_033018997.1\|457882_458209_+\|hypothetical-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	0.000367953
NZ_AP022557.1\|WP_033019007.1\|468550_469387_+\|lipoate--protein-ligase-family-protein	gnl\|CDD\|223173	COG0095, LplA, Lipoate-protein ligase A [Coenzyme metabolism].	6.03192e-82
NZ_AP022557.1\|WP_033844177.1\|453642_453885_-\|DUF2626-family-protein	gnl\|CDD\|378559	pfam11117, DUF2626, Protein of unknown function (DUF2626). This family is conserved in the Bacillaceae family. Several members are named as YqgY. The function is not known.	1.91158e-21
NZ_AP022557.1\|WP_033019000.1\|459468_460263_-\|YqhG-family-protein	gnl\|CDD\|371367	pfam11079, YqhG, Bacterial protein YqhG of unknown function. This family of putative proteins is conserved in the Bacillaceae family of the Firmicutes. The function is not known.	1.13896e-171
NZ_AP022557.1\|WP_033019002.1\|462405_463500_+\|glycine-cleavage-system-aminomethyltransferase-GcvT	gnl\|CDD\|234742	PRK00389, gcvT, glycine cleavage system aminomethyltransferase GcvT.	0
NZ_AP022557.1\|WP_033844174.1\|457455_457899_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	1.58072e-08
NZ_AP022557.1\|WP_033018998.1\|458682_459072_+\|hypothetical-protein	gnl\|CDD\|372946	pfam14173, ComGG, ComG operon protein 7. This family is required for DNA-binding during transformation of competent bacterial cells.	4.41687e-24
NZ_AP022557.1\|WP_033018995.1\|457175_457472_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|226912	COG4537, ComGC, Competence protein ComGC [Intracellular trafficking and secretion].	5.08889e-32
NZ_AP022557.1\|WP_082799286.1\|466656_467871_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.63696e-67
NZ_AP022557.1\|WP_061912159.1\|467984_468359_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	6.41771e-33
NZ_AP022557.1\|WP_081897237.1\|454819_455980_+\|type-II/IV-secretion-system-protein	gnl\|CDD\|225363	COG2804, PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion].	4.15476e-126
NZ_AP022557.1\|WP_108209741.1\|458145_458628_+\|ComGF-family-competence-protein	gnl\|CDD\|374268	pfam15980, ComGF, Putative Competence protein ComGF. ComGF is a family of putative bacterial competence proteins.	4.08168e-13
NZ_AP022557.1\|WP_033844176.1\|454021_454711_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	5.70348e-21
NZ_AP022557.1\|WP_160331357.1\|471231_471555_+\|hypothetical-protein	gnl\|CDD\|373112	pfam14528, LAGLIDADG_3, LAGLIDADG-like domain. This domain is part of the LAGLIDADG superfamily.	0.00136975
NZ_AP022557.1\|WP_033844175.1\|455976_457005_+\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224376	COG1459, PulF, Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion].	3.00474e-58
NZ_AP022557.1\|WP_061912185.1\|464874_466347_+\|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPB	gnl\|CDD\|235292	PRK04366, PRK04366, aminomethyl-transferring glycine dehydrogenase subunit GcvPB.	0
NZ_AP022557.1\|WP_033019001.1\|460249_461914_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|350769	cd18011, DEXDc_RapA, DEXH-box helicase domain of RapA. In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	2.15626e-59
NZ_AP022557.1\|WP_172418485.1\|473535_474948_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|119353	cd02874, GH18_CFLE_spore_hydrolase, Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the forespore inner membrane and is deposited as a mature enzyme in the cortex layer of the spore. As part of a sensory mechanism capable of initiating germination, CFLE degrades a spore-specific peptidoglycan constituent called muramic-acid delta-lactam that comprises the outer cortex. CFLE has a C-terminal glycosyl hydrolase family 18 (GH18) catalytic domain as well as two N-terminal LysM peptidoglycan-binding domains. In addition to SleB, this family includes YaaH, YdhD, and YvbX from Bacillus subtilis.	5.90717e-158
NZ_AP022557.1\|WP_061912160.1\|463535_464882_+\|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPA	gnl\|CDD\|234769	PRK00451, PRK00451, aminomethyl-transferring glycine dehydrogenase subunit GcvPA.	0

>NZ_AP022557.1|WP_033018999.1|459112_459295_+|YqzE-family-protein
MAVNDYVKFVTQQLVAYMDMPKEERRKRRQSRKQERPPLSYHLFGMVPFSLRLLFRRRAR
>NZ_AP022557.1|WP_033018998.1|458682_459072_+|hypothetical-protein
MERQAGVIFPFIAVVAMLFSCAVANALLLYEAERQAAEAARQAAEAEELVQMAVVDVKAQIAAASLSTAGQEGEWAYPRGVAAYRWERKDKTSVRVVLSIRSTSGLQRAVTFTVVLPALNITEWREGNG
>NZ_AP022557.1|WP_108209741.1|458145_458628_+|ComGF-family-competence-protein
MRALERLRRPRAGALRLQQTVGTSGFTLIEALISLLVAIMITAAVPLLLSARVLGTAAIDGFSPLEWRLFLQQLRIEMNETERWSVDGDVFYLQKWSGETVRFLLATRRAELIRQVNDAGYETALRHVRAVSYRTGARGLFVTVVADDGTVWEAFVARAF
>NZ_AP022557.1|WP_033018997.1|457882_458209_+|hypothetical-protein
MCKKCSKGFLLVESLLALSLLGLTAAGFLPLLVQIAAERRNLVLEEQADQLLTVAMYEQPLVGEAVVVDGRTTFRLQGREEGERTWRVCVRWNDYVGRERERCGYSKR
>NZ_AP022557.1|WP_033844174.1|457455_457899_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MRAVRNGGFTLLEMLIVLTVVLLLTGLAVPALGGVVREQNKIHMLAVLRTDLYSAQQYALAHRMKVAVFFTERGAEYKVIEAASGRQVAARSLPSPWRFQLVTLRNPLVFTGNGNIERGGTVWVQGVKQSYKLTFLLGKGRFYVQKM
>NZ_AP022557.1|WP_033018995.1|457175_457472_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MKEKGFTLIEMLIVMAVISVLLLIAIPNMTKHNSMIQSKGCEAFLNTVQAQVKAYEMEYHRVPTVQELVAARYIKSDRCPNGHAVQISADGAVSESGS
>NZ_AP022557.1|WP_033844175.1|455976_457005_+|type-II-secretion-system-F-family-protein
MRKTAWPSAEQALFFTRLGRLLERGYPLARALEFLAIQSSTPQRLELERCLQRLRDGLPLSAAMEALSVDRLAVSLLTFAERNGDLPRGLMEAGEMLTQKARFQEQLRRLTRYPLFLFLLLLVMLAIVEWWLLPQFEQAAASFSAQRGHTAQLLDVIAHFPTALAAIALLAALAALISAVSLRRWPLSRQLHWMLRIPWFASFLKMFLTQLVARQLGRLLQAGLSVYDALDAFSEPSSPSFLQMEGQRMRDGLRQGRPLDELIGAARCYEPELALVIRHGQSSGELGKELEHYSEFLLQMMERRMESALKRVQPLLLAVVGSMIIGLYLAILLPMFSMLSEW
>NZ_AP022557.1|WP_081897237.1|454819_455980_+|type-II/IV-secretion-system-protein
MFTKNFSFLAGKRLILVEINDIRIERRNGALEPIEQIASRLLAEAVRRRASDLHLVPRRYDVVVRLRLDGRLTEIGTLTKETAERIIVHFKFLAGMDIGERRRPQSGAMEVNEQGETVYLRLSTLPTLYDESLVIRLLPQRFSLPLRELSLFSHSTARLISLMQQPQGLVLLTGPTGSGKTTTLYTLLDWCQANRQRNVITLEDPVEKRNDRFLQVQINEKAGMTYASGLKAALRHDPDVLMVGEIRDQDTAVIAVRSALSGHFVVSTMHAADAVGAVYRLREFGVSPRDLAETLLAVSAQRLVELRCPLCGDACHLSCRRLGRRRRTAIHELLYGAALGEVIDSLTSESRKRRPAYLTLARLVRKGMALGYLPSRTLELVGGDER
>NZ_AP022557.1|WP_033844176.1|454021_454711_-|helix-turn-helix-domain-containing-protein
MEPTLKITSVLSDPTRFHIYEYMATIRRDVSVQEIADQFRIHPNVARLHLTKLEDVNLVVSNTQKTGKGGRPSRWYRLSDEVISLCFPFRDYQLLAHIAVQTLVGLGPSGQKVLREAGKEFGREYIANRVAHSDTIAALRSEEKIRLLTEAAGFLPRARREVKDTAMSFEFCNCPFKEIAEKQPETVCGMHHAFLEGMAEALFADARLIETENMMKGSRCCCYRLTIRP
>NZ_AP022557.1|WP_033844177.1|453642_453885_-|DUF2626-family-protein
MDRMFRVLAFWTGIFAVMFYLGHMHTTSLLFFGQTIFFLFLGFLKLTERMYIYIFSAYLTIFFAAFTYWTTFMMVPGMGE
>NZ_AP022557.1|WP_033019000.1|459468_460263_-|YqhG-family-protein
MQQHEIRRFVERYFTANGCALLEAHDDYLTVQLTAEMDKELMNRPFYWHYIERTGGVPQPMQLTLITRANERTDKLKGERLHFGAPRLHQLFRSAQKRGSFIRLYEEPNAPLNGNAALHPWLGMNVVISYECDRKKDEIVSLGIHLISGTIVESFHERLRERRLTPKIPDYCFTISPLIKPRSGIGRLEQYIESRIGADDHTWAEEARRRWADDLALLDEFYKDCEEKPECYYIEKEALEKQYKPRIIVSIVNGGLFYLLPRQP
>NZ_AP022557.1|WP_033019001.1|460249_461914_-|DEAD/DEAH-box-helicase
MNIDLEMDRTWKEEFLERVEKDGPWASWEMYELALEAAHHLIVPEFDGLQAPKHLPHVTILPHQLEVARRVVEEMNGKAILADEVGLGKTIEAGLILKEYMIRGLVKKALILVPASLVSQWVRELNEKFFIPAVQQKKSYVWEQCDIVVSSIDTAKKPPHRDIIYEQPYDMIIIDEAHKLKNNKTKNYEFVQNLKKKFCLLLTATPIQNRIEEIFNLVSLLKPGHLGSAEQFANTYGKTRAVQANDHLKALVNKVMIRNRRADTPIEWSKRHVEPVLIEFTDEERELYEAVKALRHASFAGSFSLITLLREACSSREALFLTIKNMIDKCGEAVPEPLERVLEKINAVTTNSKAEKALELIRSINDKVIIFTEYRATQLYLQWFLKQHGISSVPFRGGFRRGKKDWMQELFKHHAQVFIATEAGGEGINLQFCRHVINYDLPWNPMRLEQRIGRVHRLGQTDDVYIYNFAVKQTVEEHILTLLYEKIRLFERVVGELDDILAKMNLTNLEHYLEDAIVHSRSEGEMKIKMENIIAMIELAEQLRREGGQRHAAT
>NZ_AP022557.1|WP_033019002.1|462405_463500_+|glycine-cleavage-system-aminomethyltransferase-GcvT
MLKRTPLFPAYARYGAKTIEFGGWEMPVQFSSIKEEHEAVRTRAGLFDVSHMGEIAVRGRGSLAFLQKLMTNDVAKLRPGRAQYALMCNENGGTVDDLLIYQKGEDDYLLVVNAANTENDFAWLSEHAEGDVELEDVSAETAQLALQGPAAERVLQTLTDFDLTALRPFSFADGVEVAGMKALVSRTGYTGEDGFELYCRAEDAAALWEAILDAGARDGVLPCGLGARDTLRFEACLPLYGQELSTAISPIEAGLGFAVKTEKEPPFIGQAVLKRQKEEGPPRRLIGIEMIDRGIPRHGYVVFADGEEVGFVTTGTQSPTLKKNIGLALVKAEVAAIGREVEVDIRGKRLKANIVPIPFYRRAK
>NZ_AP022557.1|WP_061912160.1|463535_464882_+|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPA
MLHRYLPMTEEDKQEMLKTIGVASIDDLFADIPEQVRLRGKLKVKPAKSEPELWKELVALAEKNANIKQYVSFLGAGVYDHSIPAVVDHVLSRSEFYTAYTPYQPEISQGELQAIFEFQTMVCELTSMDVANSSMYDGGTALAEAVLLGAAHTKRKKVLISTAVHPQYREVVRTYAKGQKLDVKEIPYDGGVTDLKALEAEMGDDVACVVVQYPNFFGQIEPLKAIAPLVHEKKSVFVVASNPLALGVLTPPGAFGADIVVGDMQPFGIPTQFGGPHCGYFTVKAPLMRKIPGRLVGQTTDEDGRRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVALSALGKRGVKEMAAMNMQKAHYAKRELEKRGLSSPFAGPFFNEFVVRLGQPVSDVNDRLLEKGIIGGYDLGRDYPELSGHMLIAVTEVRTKEEIDRFVNELGDGHA
>NZ_AP022557.1|WP_061912185.1|464874_466347_+|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPB
MRNDQPLIFERSKPGRIAYSLPALDVPAVDVSELVPADYLRTEEPELPEVSELDLMRHYTALSRRNHGVDSGFYPLGSCTMKYNPKINENVARLAGFAHIHPLQPEKTVQGALELMYDLQEHLKEITGMDAVTLQPAAGAHGEWTGLMMIRAYHEANGDFNRTKVIVPDSAHGTNPASATVAGFETVTVQSTADGLVDLEDLKRVVGPDTAALMLTNPNTLGLFEEQIVEMAEIVHAAGGKLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPFLPKPVIEKGENGYDLDDDRPQSIGRVKPFYGNFGINVRAYTYIRSMGPDGLKAVSEYAVLNANYMMRRLADYYDLPYNRHCKHEFVLSGRRQKKLGVRTLDIAKRLLDFGFHPPTIYFPLIVEECMMIEPTETESKETLDAFIDAMIQIAKEAEENPEIVQEAPHTTVVKRLDETTAARKPILRYQKPKHSDN
>NZ_AP022557.1|WP_082799286.1|466656_467871_+|ROK-family-transcriptional-regulator
MRTGNITLVKKMNKQLVLKLIREKHPISRADIAKTTGLNKATVSALVDELIAEHFVHESGIGESTGGRRPLMLRFNADAGSLVGIELGVNYLYAVLTNLNAEIIWEQRRSFRPTEGQEAIVGEMAELIEAAIRRAPATPYGVMGIGIGVPGVVHTESGTVVFAPNLRWGDVALASALQKRWPHHPIIVENEAKLAALGEKWFGAGKEFAHFVYISAGIGIGAGVVLQHQLYRGVNGLAGEIGHHTIDLNGIRCSCGNIGCWEMYASEKYIERRLAEQGRSEWLGDRFSVAAMALAAESDEQLARILEEAGRYLGIGLLQTVYAYNPEAVIIGGSLAQAGQHVLDPARQEVKRRILVKKESEPYIIPSELKEKSCAIGAAASVLEAVVLPPEFEPALPAPQAKQG
>NZ_AP022557.1|WP_061912159.1|467984_468359_-|rhodanese-like-domain-containing-protein
MKALLIILGAIVVYSLITYLWQRRIVKALTEEEFRAGYRKAQLVDVREPDEFAAGHILGARNIPLTQLRMRMKELRKDQPIYLYCQNGLRSGRAAQMLYRKGYRHLYHLKGGFKTWTGKVKKKA
>NZ_AP022557.1|WP_033019007.1|468550_469387_+|lipoate--protein-ligase-family-protein
MAKEVWRFIDSGDCPPAFNMALDEALLDWHSQGKIPPTVRFYGWNPPTLSIGYFQKVEKEIDLEAVKRHGLGFVRRPTGGRGVLHDKELTYSVIVSESHPAMPPTVTEAYRVISQGILEGFRFLGLDAYFAVPKTEEEKADLRSPRSAVCFDAPSWYELVVEGRKIAGSAQTRQKGVILQHGSILLDLDEELLFSLFKYPNERVKERLQRDFKKKAVAINELTSRTVTMEEAKAAFYKGFEKGLNIVLEPYTLTAEEREYVETLARTKYESDEWNFKR
>NZ_AP022557.1|WP_160331357.1|471231_471555_+|hypothetical-protein
MQWSFLRGIFDADGSIRVYRRYYRDREKDYLRVRFGITGSRPLLEGILNFLKANGIAQNVNSLTAKQGCFDLYVSSINDVKKIFHHLYRYGDLKLNRKYEIFSSLMI
>NZ_AP022557.1|WP_172418485.1|473535_474948_+|LysM-peptidoglycan-binding-domain-containing-protein
MIVHVVQRGESLWQLAQRYRVPLERIVAANELDDPNRLAIGQAVVIPVPYRYHIVRAGETVWQIARAYGVAVEAIVQANRIANPAFIYPGTPLVIPARIHTVRAGETLGQIAATYQVSVQQIIEFNPIADPNVIAPGQRLVIPPAKPLIEVNAFTIDQGEKGAEQVREVGRHLTYAAPFAYTIRADGGLNPVNDVAIIQAAFAARVVPMMTITNFTYQDPGSKLAQTILAAATLQTRLLENIIQVMRAKGYRALNVDFENVYPSDRERYNAFLRRAAARLHAEGYWLSTSLAPKISAEQKGLLYEAHDYPAHGRIADFVVLMTYEWGYRFGPPQAISPVNQIRRVLDYAVTVIPREKIMMGFQIYARDWVLPHVPGQEAETFSPKEALERAIRYGASIQYDAAAASPFYRYTDEQGRQHEVWFEDARSALAKFDLVKEYGLRGISYWVLGYPYPENWGLLEDHFRIRKRG

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Crispr_ID: NZ_AP022557_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_4

553121-553209

Orphan

Consensus_repeat	Method
CGTCTAGTTTTATAACGCTGCCAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_4

>merge|NZ_AP022557|4|553121-553209|CRISPRCasFinder
CGTCTAGTTTTATAACGCTGCCATACAAGCAGTCAAGGACGCATCAACATGCAGTCGCCTCATGACGTCTAGTTTTATAACGATGCCAT

>NZ_AP022557|4|4|553121-553209|CRISPRCasFinder
CGTCTAGTTTTATAACGCTGCCAT	ACAAGCAGTCAAGGACGCATCAACATGCAGTCGCCTCATGA
CGTCTAGTTTTATAACGATGCCAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033844120.1\|559297_560320_-\|NADPH-dehydrogenase-NamA	unknown	unknown	gnl\|CDD\|184110
NZ_AP022557.1\|WP_033844130.1\|548061_548817_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_AP022557.1\|WP_033844128.1\|549911_550601_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_AP022557.1\|WP_033844132.1\|542623_544033_+\|NADP-dependent-phosphogluconate-dehydrogenase	unknown	unknown	gnl\|CDD\|236453
NZ_AP022557.1\|WP_033023566.1\|544171_544354_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033844124.1\|555104_555416_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224913
NZ_AP022557.1\|WP_033844133.1\|542049_542244_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033844118.1\|561941_562913_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293811
NZ_AP022557.1\|WP_033844121.1\|558377_559301_+\|ribonuclease-Z	unknown	unknown	gnl\|CDD\|274246
NZ_AP022557.1\|WP_033844131.1\|546139_548065_-\|FtsX-like-permease-family-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_025948590.1\|554687_555104_-\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350250
NZ_AP022557.1\|WP_033844127.1\|551208_553020_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225926
NZ_AP022557.1\|WP_033844129.1\|548910_549915_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340424
NZ_AP022557.1\|WP_033844119.1\|560591_561431_-\|pyrroline-5-carboxylate-reductase	unknown	unknown	gnl\|CDD\|181079
NZ_AP022557.1\|WP_033844122.1\|556551_558063_-\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|235579
NZ_AP022557.1\|WP_033023571.1\|541371_541845_+\|purine-binding-chemotaxis-protein-CheW	unknown	unknown	gnl\|CDD\|223905
NZ_AP022557.1\|WP_033844125.1\|553275_554643_+\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NZ_AP022557.1\|WP_033844117.1\|562903_563692_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_AP022557.1\|WP_033844123.1\|555638_556256_-\|cyclase-family-protein	unknown	unknown	gnl\|CDD\|224790
NZ_AP022557.1\|WP_033844956.1\|544368_544917_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033844120.1\|559297_560320_-\|NADPH-dehydrogenase-NamA	gnl\|CDD\|184110	PRK13523, PRK13523, NADPH dehydrogenase NamA; Provisional.	0
NZ_AP022557.1\|WP_033844130.1\|548061_548817_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	5.2953e-112
NZ_AP022557.1\|WP_033844128.1\|549911_550601_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.47678e-69
NZ_AP022557.1\|WP_033844132.1\|542623_544033_+\|NADP-dependent-phosphogluconate-dehydrogenase	gnl\|CDD\|236453	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase.	0
NZ_AP022557.1\|WP_033844122.1\|556551_558063_-\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0
NZ_AP022557.1\|WP_033844124.1\|555104_555416_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	gnl\|CDD\|224913	COG2002, AbrB, Regulators of stationary/sporulation gene expression [Transcription].	2.0912e-08
NZ_AP022557.1\|WP_033844117.1\|562903_563692_+\|SDR-family-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	1.55753e-88
NZ_AP022557.1\|WP_033844118.1\|561941_562913_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293811	cd07725, TTHA1429-like_MBL-fold, uncharacterized Thermus thermophilus TTHA1429 and related proteins; MBL-fold metallo hydrolase domain. Includes the MBL-fold metallo hydrolase domain of uncharacterized Thermus thermophilus TTHA1429 and related proteins. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	2.82018e-43
NZ_AP022557.1\|WP_033844127.1\|551208_553020_+\|hypothetical-protein	gnl\|CDD\|225926	COG3391, COG3391, Uncharacterized conserved protein [Function unknown].	2.20507e-06
NZ_AP022557.1\|WP_025948590.1\|554687_555104_-\|PIN-domain-containing-protein	gnl\|CDD\|350250	cd18683, PIN_VapC-like, Uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	4.41818e-22
NZ_AP022557.1\|WP_033844119.1\|560591_561431_-\|pyrroline-5-carboxylate-reductase	gnl\|CDD\|181079	PRK07679, PRK07679, pyrroline-5-carboxylate reductase; Reviewed.	3.04111e-158
NZ_AP022557.1\|WP_033023571.1\|541371_541845_+\|purine-binding-chemotaxis-protein-CheW	gnl\|CDD\|223905	COG0835, CheW, Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms].	1.85527e-32
NZ_AP022557.1\|WP_033844129.1\|548910_549915_-\|sensor-histidine-kinase	gnl\|CDD\|340424	cd16948, HATPase_BceS-YxdK-YvcQ-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ. This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.	1.05399e-48
NZ_AP022557.1\|WP_033844125.1\|553275_554643_+\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	0
NZ_AP022557.1\|WP_033844123.1\|555638_556256_-\|cyclase-family-protein	gnl\|CDD\|224790	COG1878, COG1878, Kynurenine formamidase [Amino acid transport and metabolism].	2.63104e-52
NZ_AP022557.1\|WP_033844121.1\|558377_559301_+\|ribonuclease-Z	gnl\|CDD\|274246	TIGR02651, Ribonuclease_Z, ribonuclease Z. Processing of the 3-prime end of tRNA precursors may be the result of endonuclease or exonuclease activity, and differs in different species. Member of this family are ribonuclease Z, a tRNA 3-prime endonuclease that processes tRNAs to prepare for addition of CCA. In species where all tRNA sequences already have the CCA tail, such as E. coli, the need for such an enzyme is unclear. Protein similar to the E. coli enzyme, matched by TIGRFAMs model TIGR02649, are designated ribonuclease BN. [Transcription, RNA processing].	1.68078e-153

>NZ_AP022557.1|WP_033844127.1|551208_553020_+|hypothetical-protein
MGTTFRKGCLFCLFLFICLVHVSPSAKAEAAGPRTQQLPGRVLDWVMDDQNGYIYALTEKGTLLFIEAGTLSIKKQETVSLRAYSALWRKYAQRSITLLLRNGKLYVPSETSIDVFDVKTKRLIQRAPYSGLPFGLLGNKIVTFGEQYGRGKTTYEMYMWDLATKRQTSRLIADPNFSAVFSAENTLVFDEKRGLAFIGRNFAIPDLAVLRLSDLKVVKRVSYQGPTGSEPTHPLIVDGNDVFFAGRRIDAGNINMVHDCYNGPVLDVQRTYVVTNEAVYDRYTSAKVSALPFPTNYALMDVKYNLYLIKEGENRIYKYLLPADESYYVPSSHYAFTNVPISHLAYDSSTGWLYVLSAEDSKLFVIRASDMKIVKEIHPGPQPTDIEIDGGKVYVALSGATKIAIYDAKTMRFLGTVPLIAAPRTLAIGGGKIFFTDNSRTLTGAVAVYDMKTKKQWRIPKAFINPMIVYDKKQNVLYVGQEGTSDHALYAVRLSDWHVSELLSLPGGDDAFFMNGGEIFYGTARIHPAHSGALVAAQFSEPLRAASRQYIITSRAIYNRATGTKIADLSSEALLAAAGDDGMIFTYQKVAGNHYLIKQKPSR
>NZ_AP022557.1|WP_033844128.1|549911_550601_-|response-regulator-transcription-factor
MNILLIEDDATLFQEIKQRLEQWSYNVCGIRDFSRVMEEFSHCQPHLVIIDIQLPKFDGFHWCRQIRAHSNVPILFLSSRDHPTDMVMSMQLGADDYIQKPFHFDVLIAKIQALLRRVYDYNAGPIHLQTWCGATIDYAKSTVTNEQGTVELTKNELLILKHLLNKKNTIVTRTELIEQLWEDERFISDNTLTVNVNRLRKKLDELGLGRFIETKVGQGYMAKEEGIGS
>NZ_AP022557.1|WP_033844129.1|548910_549915_-|sensor-histidine-kinase
MIKDYLMERKSWLAFFLFLELFILFVAYLDPTIPFSSALYIVFLTSILFAVFVIIRWKKETAFYQRLQTCHLALDPASSLQAASPFERIVERALASQMDQWKQELAVWRTALEQERDELLTWIHEMKTPLTAMRLMIERVEEENAKSSLLYEWLRIHLLLDQQLHQRRLPHMENDLYIEHVELKPLLINEIKPLQPWCMQKGIGFDLQLNVRSVLSDAKWLSFIIRQIVTNAVKYSESCDIIVKSFLENGHIHLQIQDFGRGIDPKDLPRIFDKGFTSTAEHQNETATGMGLYLAKKAAQPLLLDFHVESSPGRGTVFTIVFPQENDLIRMHGM
>NZ_AP022557.1|WP_033844130.1|548061_548817_-|ABC-transporter-ATP-binding-protein
MMILEATNIRKIYGTKKNQQEVLKGIDLRVEKGEFLAIMGPSGSGKTTLLNVLSSIDRVSEGAIFIEGNNIVAMKDRELAEFRKRHVGFIFQEYHLLDTLTVKENVLLPLSITKTPKREAEKKFAELASELGIIDIQNHYPSEISGGQKQRAAAARAFIHEPSIIFADEPTGALDSKSASDLLHKLRKLNQQRKTTIIMVTHDPVAASFSSRVVFIKDGQLYTQLYKGTETQQQFFQAIMQTQGVLGGVRS
>NZ_AP022557.1|WP_033844131.1|546139_548065_-|FtsX-like-permease-family-protein
MSMKQLVFRNLKQNIQHYYLYVFALMFASALYFAFVTLQYDPALDAIKGGVKGAAAVRTGAVLLIVIVAIFLLYANTLFIQRRGHEIALLQLIGMTKRNIFLMLAAENAILYYGTLIIGISMGFAASKLLMMILFKIIDIPVKASLSFSGRALVQTLIVFSVINVFMMGMNRLFLKKQTIVSLFRTTSTTEAKHVSVWNMVVGMAGIVLIGSGYGISMKLFSSDWKSVQGLFMAMAFILGAVIIGTYLFFKGTISFLFHLWRKRKGGYLSIDDVLSMSSLMFRIKSNALLLTIITTVSAIAIGLISLSYISYYSAEQAAQNYVAADFAFTDKKDAARFTAALRSHDIRYRETMIDVIETPTDISMILDIADQSRLQFQPSAATLSVISDTSTGRIDVKPGEAVLTGYQDILRQFLPFKETGMIRLEANGRMVPLHYLGMKKDYYVNYHFTHGMPTVVVDQTMFARLQKETDPQMKKVHIGIHLTDETNIERADQLFQRMEFSSIADSRLIMSRYQKQTFGLIMFVVTFLGLAFLVTSGCILYFKQMGAGEEERPNYTILRKLGFTENDFFTGIRQKQLFYFGVPLLLGLSHSYFAVRSGWFFFGTELWTPMLTVMAIYTVCYSLFGMLAVRYDKQLLREAL
>NZ_AP022557.1|WP_033844956.1|544368_544917_-|hypothetical-protein
MTRKSNAYQITYNGVEIIIDSVNNMGTSEKIRIAEQMIDSELLHSSPFFASNNNLVIPQVIPNPGDGTVIGTRYYAFDNDTAKFVSSVLKTGLTAIATAAGYTFGPGAATTIASICTLAGEYINLKPYWTTVKIIRYYSEYYDQYIYDAYHFVYSDSKRTNLKRVYISDDMIKTTGNVLDTF
>NZ_AP022557.1|WP_033023566.1|544171_544354_-|hypothetical-protein
MFMNRKKRFILFLAVLMVIFFFIYMFEEQVLRFLDYKAVKLTMLISLITIIVGDAIYRRA
>NZ_AP022557.1|WP_033844132.1|542623_544033_+|NADP-dependent-phosphogluconate-dehydrogenase
MAKQQIGVIGLAVMGKNLALNIESKGYSVAVYNRSREKTDEFLQEAKGKNIVGTYSIEEFVNALEKPRKILLMVKAGAPTDATIEQLKPHLEKGDIVIDGGNTYFKDTQRRNKELAELGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVRPIFEAIAAKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYFLLKHALGMDAAELHEVFADWNKGELNSYLIEITADIFTKIDEETGKPLVDVILDKAGQKGTGKWTSQNALDLGVPLPIITESVFARFISAMKDERVKASKVLAGPAVKPFEGDRAHFIEAVRRALYMSKICSYAQGFAQMKAASEEYDWNLRYGDIAMIFRGGCIIRAQFLQKIKEAYDRDPALPNLLLDPYFKDIVERYQDALREIVATAAMRGIPAPGFASALAYYDSYRTAVLPANLIQAQRDYFGAHTYERVDKEGVFHTEWLK
>NZ_AP022557.1|WP_033844133.1|542049_542244_+|hypothetical-protein
MVRPFGPYMDGFYPPYYGGYGYYPYGYHHHHWHGGYDGYPHFPYGMPYGHYPFSPYGFPHYGGY
>NZ_AP022557.1|WP_033023571.1|541371_541845_+|purine-binding-chemotaxis-protein-CheW
MDKYVVFRVEREQYAVSIAYVVSIEKMTAPTAVPHMPDYMAGVVRIRGELVPVLDMRKLLYGRAIEETDQTRLVVAAVDGLSVALIVDEAKEIADIEPEAIQPLQLMSAERTPYLVGMATLPDRLLTVLDPRVLFNHLEEAEEIREQIAAVQSDEVV
>NZ_AP022557.1|WP_033844125.1|553275_554643_+|glycoside-hydrolase-family-1-protein
MSQQCKSIIPDGFLWGGAVTSFQTEGAWNEGGKGLSIVDARPIPEGHSDWKVAVDFYHRYKEDIALFKELGFTAYRTSIAWTRIFPDGEGEPNEAGLAFYDAVFDELRANGIEPVITLYHFDLPLALAKKYNGFASRKVVDLFERYARTVFARYRGKVNYWLTFNEQNLVLEQPHLWGAICPDDEDPEAFAYRVCHHVFLAHAKAVKALREIAPEAKIGGMATYLTTYPATCRPEDALANVQAKELFIDFFFDVFARGVYPRYVTRRLEKKGIRLPLEAGDEELLRAQTVDFLSFSYYQSQIVRHQEQDERIIKGLAPNPHLPKTKWGWAIDPLGLRIALKDVYARYQMPIFITENGIGLEEELNENGTVDDDERIDYMRRHIEQMKLAIEEGVEVIGYLMWGATDLLSSQGEMRKRYGVIFVNRDDQNLRDLKRYKKKSFYWFQRVIRTNGEEL
>NZ_AP022557.1|WP_025948590.1|554687_555104_-|PIN-domain-containing-protein
MARKLWIDTNVVIRIMTGHPQELAEEVGDMLQKVEAGELILRLNPLVVAECCWVLASVYQASPSDISAALLKFTNGIGIETEEKDVVQQALRDYGEKKVDFIDAYIAAHAKANPPEDVVTWDKHFKRLNIRHGRPKDW
>NZ_AP022557.1|WP_033844124.1|555104_555416_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein
MEKMNVSDQPSPVVMKATSKLSSRGQVVIPVEIRKTLGLNEGDDLTFIVNQDGEIKVEVTKKYRLSQLIGILKTNQPFRPIEEIRDEVYRTIGAKELKDGEEN
>NZ_AP022557.1|WP_033844123.1|555638_556256_-|cyclase-family-protein
MTMYDVTAPIYEGMPVYKNKPEKQPKRTTVTNGYVTESRIDMDVHTGTHIDAPLHMVEGGATFETIPLDRLVGPCKLFDLTHVNDRITKDDIGHLDIQEGDFVLFKTKNSFEDAFNFEFIFVAEDAARYLAAKPIRGVGIDALGIERAQEGHPTHKTLFSAGVIVIEGLRLKEVPEGRYFMVAAPLKLVGTDAAPARVLLFDREL
>NZ_AP022557.1|WP_033844122.1|556551_558063_-|glucose-6-phosphate-dehydrogenase
MDNMNPKSIIVIFGATGDLAKRKLFPSLYRLYEKGHLNERFAVVGVARRPLSVDEFRNDVRDSVETAFQQPLADERFISHFYYHPFDVTEAESYQRLKSLLEQLDDTYATEGNRIFYLAMAPEFFGTVTSRLQSEGLSETRGFKRLVIEKPFGHDLASAEKLNDEIRRVFSEREIYRIDHYLGKEMVQNIEVIRFSNAIFEPLWNNRFIANIQITSSETLGVEDRGRYYDHSGALRDMVQNHMLQMVALLAMEPPIKLTTDDIRHEKVKVLRALRPISHDDVDRYFVRGQYGRGMIHGKAVPAYREEPNVDPESNTETFVAGKLLIDNFRWAGVPFYIRTGKRMAEKSTKIVVQFKDVPMNLYYRTNETIAPNLLVIHIQPDEGITLHLNGKKTGESTTTTAPFQLDYCNNCIDGINTPEAYEKLLYDCMRGDATNFTHWDEVAASWQFIDPISDVWTNTKAADFPNYEAGLMGPKAADELLQKDGFHWWPISHPRSEKAGAN
>NZ_AP022557.1|WP_033844121.1|558377_559301_+|ribonuclease-Z
MELLFLGTGAGVPAKERNVSSVALQLLDERGATWLFDCGEATQHQILHTAIRPRRIEHILITHLHGDHLFGLPGLLGSRSFQSGETPLTVFGPRGLRAFVETALAVSGTKLRYELNIAEIEEGVIFDDETFQVIAKRLDHGMPSYGFRVVEKDLPGPLLVDRLRALGVRPGPIYQQIKQGKTVVLEDGIVLDGREFVGPPQKGRIVTVLGDTRFCEAAIELAHDADVVVHEATFAAAEQQLAHDYFHSTTIDAAEVARRARAKRLILTHISSRYQGAAAQQLVAEARRVFPNTELAADFASFSIPRG
>NZ_AP022557.1|WP_033844120.1|559297_560320_-|NADPH-dehydrogenase-NamA
MNTMLFSPYTIGGLTLKNRIVMSPMCMYSCETKDGTVRTWHKIHYPARAVGQVGLIIVEATGVTPQGRISERDLGIWSDDHIPGLNELVGLVKEHGAAIGIQLAHAGRKAEVPGEIIAPSAIPFQESSRTPKEMTKADIEETVQAFQNGARRAKEAGFDVIEIHAAHGYLINEFLSPLANRRQDEYGGSPENRYRFLGEVIEAVREVWDGPLFVRISASDYHPDGLTASDYVPYAKRMKEQGVDLIDVSSGAVVPARIDVYPGYQVPFAELIRREADIPTGAVGLITSGWQAEEVLRNGRADLVFLGRELLRNPYWPYAAARELGVSIEAPVQYERGWRF
>NZ_AP022557.1|WP_033844119.1|560591_561431_-|pyrroline-5-carboxylate-reductase
MNNGQTIALIGAGSMAEALIAGMTKAFCRPTDVIVANRQNRARLEELARRYGVRVAPNAREAAEQADIIVLAMKPKDVAEAMNTIAPALCANPLILSLLAGVTTETIERLAGRDIPVVRAMPNTSAAVGLSATAIAGGRFAAKEHLEVAKQLFETVGIVAVVPERDLHAVTGLSGSGPAYVYYLVEAMERAASDIGLEPEVAKPLILQTIIGAAEMLKASDKHPSVLRREVTSPGGTTEAGIGVLEQYRFQEAVIACIRRATARSEELGSALLAAIAEA
>NZ_AP022557.1|WP_033844118.1|561941_562913_+|MBL-fold-metallo-hydrolase
MNEERVHRITVPTPFPVGDVHMYVIAGDRLTLVDAGVKTEEAWQRFVHRLAEIGYRPEEIEQIVITHHHPDHVGLLDYFPHAPIIGHPKADPFLRRERAFIERYVRFFEGFFTECGVDRRLFSRLSKEGGSLRYASRRAVDIAVTDGDAVPGLPRWRVIETPGHAQSHIVLYREEDGLLIGGDHLLVHISPNPMMEPPAEGETERPKPLLQYNESLEKMLQYDIVRSLNGHGDDATDIPALVRERLDKQRQRAERVLEMVKERPHTVFDVCQKLFPTAYERQLMLTMSETIGQLDYLEANGYVTKKQEAGRYVYEAAGVSVCG
>NZ_AP022557.1|WP_033844117.1|562903_563692_+|SDR-family-oxidoreductase
MRLKGCHVVITGASGGIGEHIADEAARQGALPVLLARSEEKLKEISARIEAQTGIRPRYARLDVGDREMVEAVFSRLMAELETVDVLVNNAGFGVFRYVEDIDLAEMERMFAVNVFGLIACTKAVYPHMKERKSGHIINIASQAGKIATPKSSVYSATKHAVLGFTDSLRLEAGRFGIFVTAVNPGPVETNFFSAADESGEYVRNVSRWMVSPEAVARRVVAAMMTPTREVNMPRWMDFGSRLYRLAPGLVETVAKRAFFQK

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Crispr_ID: NZ_AP022557_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_5

593949-594040

Orphan

Consensus_repeat	Method
ACGGGCCATATGGTCGGCCATGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_5

>merge|NZ_AP022557|5|593949-594040|CRISPRCasFinder
ACGGGCCATATGGTCGGCCATGAGCTTGCATCGTCTTCCACGCCGAGCATGTGCCGATGAAAACTTTACAGGCCATATGGTCGGCCATGAGC

>NZ_AP022557|5|5|593949-594040|CRISPRCasFinder
ACGGGCCATATGGTCGGCCATGAGC	TTGCATCGTCTTCCACGCCGAGCATGTGCCGATGAAAACTTT
ACAGGCCATATGGTCGGCCATGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033844106.1\|590063_590528_+\|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl\|CDD\|234606
NZ_AP022557.1\|WP_033844094.1\|601441_602629_+\|c-type-cytochrome-biogenesis-protein-CcsB	unknown	unknown	gnl\|CDD\|274447
NZ_AP022557.1\|WP_033023507.1\|586131_586572_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NZ_AP022557.1\|WP_033844098.1\|597611_598145_+\|spore-maturation-protein	unknown	unknown	gnl\|CDD\|223772
NZ_AP022557.1\|WP_033844096.1\|599258_599783_+\|thiol-disulfide-oxidoreductase-ResA	unknown	unknown	gnl\|CDD\|179545
NZ_AP022557.1\|WP_033844102.1\|593335_593728_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033844103.1\|592659_593286_+\|SMC-Scp-complex-subunit-ScpB	unknown	unknown	gnl\|CDD\|234657
NZ_AP022557.1\|WP_033844100.1\|594334_595591_+\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NZ_AP022557.1\|WP_033844107.1\|588851_590045_+\|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II	unknown	unknown	gnl\|CDD\|181774
NZ_AP022557.1\|WP_033023498.1\|591758_592514_+\|segregation/condensation-protein-A	unknown	unknown	gnl\|CDD\|234635
NZ_AP022557.1\|WP_081897231.1\|587076_588177_+\|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	unknown	unknown	gnl\|CDD\|273015
NZ_AP022557.1\|WP_033844105.1\|590639_590996_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_AP022557.1\|WP_033844093.1\|603448_605242_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|380161
NZ_AP022557.1\|WP_033021090.1\|602723_603449_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_AP022557.1\|WP_033844951.1\|595907_597023_+\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NZ_AP022557.1\|WP_033844104.1\|591036_591549_-\|DUF309-domain-containing-protein	unknown	unknown	gnl\|CDD\|377120
NZ_AP022557.1\|WP_033844095.1\|599796_601455_+\|cytochrome-c-biogenesis-protein	unknown	unknown	gnl\|CDD\|224252
NZ_AP022557.1\|WP_033844108.1\|588176_588824_+\|riboflavin-synthase	unknown	unknown	gnl\|CDD\|236455
NZ_AP022557.1\|WP_033844099.1\|597015_597612_+\|spore-maturation-protein	unknown	unknown	gnl\|CDD\|225336
NZ_AP022557.1\|WP_033844097.1\|598263_598995_+\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033844106.1\|590063_590528_+\|6,7-dimethyl-8-ribityllumazine-synthase	gnl\|CDD\|234606	PRK00061, ribH, 6,7-dimethyl-8-ribityllumazine synthase; Provisional.	8.38899e-90
NZ_AP022557.1\|WP_033023507.1\|586131_586572_+\|peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	2.46518e-62
NZ_AP022557.1\|WP_033844098.1\|597611_598145_+\|spore-maturation-protein	gnl\|CDD\|223772	COG0700, SpmB, Uncharacterized membrane protein [Function unknown].	3.7124e-57
NZ_AP022557.1\|WP_033844096.1\|599258_599783_+\|thiol-disulfide-oxidoreductase-ResA	gnl\|CDD\|179545	PRK03147, PRK03147, thiol-disulfide oxidoreductase ResA.	7.87367e-117
NZ_AP022557.1\|WP_081897231.1\|587076_588177_+\|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	gnl\|CDD\|273015	TIGR00326, eubact_ribD, riboflavin biosynthesis protein RibD. This model describes the ribD protein as found in Escherichia coli. The N-terminal domain includes the conserved zinc-binding site region captured in the model dCMP_cyt_deam and shared by proteins such as cytosine deaminase, mammalian apolipoprotein B mRNA editing protein, blasticidin-S deaminase, and Bacillus subtilis competence protein comEB. The C-terminal domain is homologous to the full length of yeast HTP reductase, a protein required for riboflavin biosynthesis. A number of archaeal proteins believed related to riboflavin biosynthesis contain only this C-terminal domain and are not found as full-length matches to this model. [Biosynthesis of cofactors, prosthetic groups, and carriers, Riboflavin, FMN, and FAD].	3.90523e-146
NZ_AP022557.1\|WP_033844103.1\|592659_593286_+\|SMC-Scp-complex-subunit-ScpB	gnl\|CDD\|234657	PRK00135, scpB, segregation and condensation protein B; Reviewed.	3.21782e-84
NZ_AP022557.1\|WP_033844100.1\|594334_595591_+\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	2.05429e-89
NZ_AP022557.1\|WP_033844107.1\|588851_590045_+\|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II	gnl\|CDD\|181774	PRK09311, PRK09311, bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II.	0
NZ_AP022557.1\|WP_033023498.1\|591758_592514_+\|segregation/condensation-protein-A	gnl\|CDD\|234635	PRK00104, scpA, segregation and condensation protein A; Reviewed.	6.72314e-114
NZ_AP022557.1\|WP_033844094.1\|601441_602629_+\|c-type-cytochrome-biogenesis-protein-CcsB	gnl\|CDD\|274447	TIGR03144, cytochrome_c_biogenesis_protein_chloroplast, cytochrome c-type biogenesis protein CcsB. Members of this protein family represent one of two essential proteins of system II for c-type cytochrome biogenesis. Additional proteins tend to be part of the system but can be replaced by chemical reductants such as dithiothreitol. This protein is designated CcsB in Bordetella pertussis and some other bacteria, resC in Bacillus (where there is additional N-terminal sequence), and CcsA in chloroplast. We use the CcsB designation here. Member sequences show regions of strong sequence conservation and variable-length, poorly conserved regions in between; sparsely filled columns were removed from the seed alignment prior to model construction. [Energy metabolism, Electron transport, Protein fate, Protein modification and repair].	6.35343e-49
NZ_AP022557.1\|WP_033844105.1\|590639_590996_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.72598e-09
NZ_AP022557.1\|WP_033844093.1\|603448_605242_+\|HAMP-domain-containing-protein	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	2.1142e-112
NZ_AP022557.1\|WP_033021090.1\|602723_603449_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.06855e-96
NZ_AP022557.1\|WP_033844951.1\|595907_597023_+\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	1.38612e-93
NZ_AP022557.1\|WP_033844104.1\|591036_591549_-\|DUF309-domain-containing-protein	gnl\|CDD\|377120	pfam03745, DUF309, Domain of unknown function (DUF309). This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	1.26839e-18
NZ_AP022557.1\|WP_033844095.1\|599796_601455_+\|cytochrome-c-biogenesis-protein	gnl\|CDD\|224252	COG1333, ResB, ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones].	6.01843e-140
NZ_AP022557.1\|WP_033844108.1\|588176_588824_+\|riboflavin-synthase	gnl\|CDD\|236455	PRK09289, PRK09289, riboflavin synthase.	1.34863e-109
NZ_AP022557.1\|WP_033844099.1\|597015_597612_+\|spore-maturation-protein	gnl\|CDD\|225336	COG2715, SpmA, Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only].	1.34104e-88
NZ_AP022557.1\|WP_033844097.1\|598263_598995_+\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	1.55212e-106

>NZ_AP022557.1|WP_033844102.1|593335_593728_+|hypothetical-protein
MDVCRLHGEELEKSQANTFEDYFNRSEVTYSDGGEERTLSVLYLRHFETALLELLPYEGDPLFVANGRDIYLRDLVALVCLWQNPAYRRRKRVYIHDEAELCRYFAAVPNEALQALVSEWAATGRSRLPE
>NZ_AP022557.1|WP_033844103.1|592659_593286_+|SMC-Scp-complex-subunit-ScpB
MEEKEAGKTGTAGSQLAPQAIVEALLFAAGDEGLSLAQIAAVLEIDEAEAKAVLAKLQEDCEREERGIQLIELGGVFLLATKKEHAPYLKRLVEAPGASPLSQAALETLAIIAYRQPITRAEIEEIRGVKSDKPLQTLMARALIKEVGRAEGTGRPILYGTTAEFLDYFGLKTLEELPPLPEWADDHEPEREADLFFEKLTEQWSDEP
>NZ_AP022557.1|WP_033023498.1|591758_592514_+|segregation/condensation-protein-A
MDVQLSYNVKIEAFEGPLDLLLHLIHRYEIDIYNIPVAQITEQYMAYIHAMQELELDMASEYLVMAATLLALKSKMLLPAPEEEAGDGELEFTDDVDPREELMQRLLEYKKFKEAARALKQREEERALLFTKPPSDLSAYADEKKAAPLDVNVYDMLGALSKLLRRKKLQKPLRAKIARQDLSVEKRMAEILQELRETNGRKNFYDLFPVYDRAYIVVTFLAVLELIKQNEIIVEQERNFSDLFLAARPSG
>NZ_AP022557.1|WP_033844104.1|591036_591549_-|DUF309-domain-containing-protein
MYPKAYIDYLVHFHGDRDYFECHELLEEQWKRDGRPNGWLVLIQIAVAFYHYRRGNMSGALRLIRRAQALLEEARGMIRQLGLDDQALETLLGDTAARIVRGEPYRSVELPIRDRSLYEQCLAACAKQQLAWGQPSDLGNVDVVNKHQRRDRSGILAERERKKRAKAEGK
>NZ_AP022557.1|WP_033844105.1|590639_590996_+|GNAT-family-N-acetyltransferase
MFIRYRKNYEKIAMGLLSFMPTEKDLKRLQQTIKQYETNDDWQLFLWKEEEDIVGLIGVLLRAPDVVEIQHISVNPSHRHQGIGKQMVKALKETYPDRRLCANEWTASFLDKCNACHE
>NZ_AP022557.1|WP_033844106.1|590063_590528_+|6,7-dimethyl-8-ribityllumazine-synthase
MNVIEGHLVGTGLKIAIVVARFNEFITGKLLSGAIDGLTRHGVSDHDITVAWVPGAFEIPLVAKKLAESKQFDAVITLGAVIRGATSHFDYVCSEAAKGVSQAAFASGVPVIFGVLTTDTIEQAIERAGTKAGNKGWEAAVSAIEMANVLRAFA
>NZ_AP022557.1|WP_033844107.1|588851_590045_+|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II
MFDSIEAALAALANGEVIIVCDDEDRENEGDFVALAEKVTPDIINFMITHGRGLVCVPITEELAERLGLEPMVAHNTDAHGTAFTVSIDYKTTTTGISAHERAATIQALLDPNVKASDFKRPGHIFPLIAKKGGVLRRAGHTEAAVDLARLCGAAPAGVICEIIKEDGTMARVPDLRQMADQFGLKMITIKDLIAYRSEREKLVKREVDIWLPTEFGEFRAIGYTNVLDGKEHVALVKGEITPDEPILVRVHSECLTGDVFGSYRCDCGPQLHAALRQIEAEGRGVLLYMRQEGRGIGLMNKLRAYKLQEQGYDTVEANEKLGFPADLRDYGIGAQMLKDLGVTKMRLLTNNPRKIAGLKGHGLEVVERVPLEMPPKKENEQYLRTKYEKLGHMLHF
>NZ_AP022557.1|WP_033844108.1|588176_588824_+|riboflavin-synthase
MFTGIIEEIGTIERMNATGDAIVMAISAKRVLEDVQLGDSIAVNGVCLTVTSFDDRRFTVDIMPETVKATALKTLKPGSKVNLERAMAANGRFGGHFVSGHVDGVGRIIRQWPKANAVYYEIEVLAPLRAYMMEKGSVAVDGTSLTIFGLSERTFTVSLIPHTRAATILGEKRPGDLVNIECDMIGKYVAAFLAAKAAPPARGLTVDFLEQHGYK
>NZ_AP022557.1|WP_081897231.1|587076_588177_+|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD
MYRDEDYMRLALNVAKAGSGQTSPNPLVGAVVVNGGEVVGLGAHLKAGQPHAEVHAIRMAGDKARGATVYVTLEPCSHYGKTPPCADLLIEAGVRRVVVATTDPNPLVAGKGIDKLRQAGIHVDVGILKEEADELNRMFFHSIATKTPFVTLKYACSLDGKIATATGESQWITSSAAREDVHRLRAQHDAILVGVNTVIADNPKLTVRIGEQRKNPLRIILDTRLRTPLDAHVVTDREAETWIIAGRGASREKAVAYERRGVRVVSLPTDRVEVGAVLRLLGEQKVMSLFVEGGSRVHDSFLRAGAVNEVVAYIAPKLIGGQDAPTPIGGLGFPRLAEALELDIRRVERIGPDVKIAAVPKRKEEA
>NZ_AP022557.1|WP_033023507.1|586131_586572_+|peptidylprolyl-isomerase
MAKKGYILMENGGKIEFELFPNEAPVTVANFEKLANEGFYDGLTFHRVIPGFVSQGGCPRGNGTGDAGYTIPCETDNNPHRHVAGAISMAHRGRDTGSCQFFIVHEPQPHLDGMHTVFGQVTSGLDVVKAMKNGDVMKEVKVFDEQ
>NZ_AP022557.1|WP_033844100.1|594334_595591_+|superoxide-dismutase
MDDQTLLAQYVAELSEWGEQVRQALAWRGASTEGVAALLSVIAEHDGAWTKEEVRELQRRADAVYAAALRHYAFEAAEWGKQVEQALAWRGAAEDIGLSALSAYIDQHNDAWTEETIVALQQLVDEVYERAVRLVGAPSGGQGQAAGLAAAQTAGVTVAEARTEVDGEREDEQRSTLVDEKEEANAWATAGNPTPFLGSSWDSLGRERQPAVPPGKHVLPPLPYKYDALEPHISEEIMRLHHTKHHQSYVDGLNQAERMMAEARRTNRFELLKHWEREAAFHGSGHYLHTIFWYNMDPNGGGEPRGELRAQIERDFGSFAAFRRHFTEAAKSAEGVGWALLVWAPRAHRLEILQAEKHQLMAQWDVIPLLVLDVWEHAYYLQYKNDRAAYIANWWNVVNWRNVEARFAKAQKLRWLPF
>NZ_AP022557.1|WP_033844951.1|595907_597023_+|D-alanyl-D-alanine-carboxypeptidase
MALAAGIIALIPGRMDAMNGVSAKSAILMEQHSGRVLFAKDAYTKRRIASITKIMTAVLAIESGKMDDLVTVSARAVRTEGSSIYLRQGEKIKLRDLVYGLMLRSGNDAAVAIAEHVGGSVEGFVFLMNKKAAEIGMHDTEFANPHGLDDAENHYSTAYDMALLMQYAMKNSEFRRISGTKVYRAPAPPGEEGARVWRNKNKLLTGLYEYCTGGKTGYTKRAHRTLVTTASKDGVNLIAVTLDAPDDWNDHIAMYEYGFSHYHIANVSGKRIVGKITDPFYEGRLRAARDLQYPVTSEEENELRVNVYLLKPRAEWKEDPDRVPAAVGKAVLYLHDKAVDETPLLYEHKKEESGENSFWDLFSFLGVRSDG
>NZ_AP022557.1|WP_033844099.1|597015_597612_+|spore-maturation-protein
MVNLIWVMMAVVGIVFAAINGTMEEVNKAVFESAKEAVTISIGMISVLVFWLGLMAIAERAGLLHKVARLFMPIVRRLFPEVPPGHPALGYIVSNMVANMFGLGNAATPMGIKAMEQLKQLNGGRDEASRSMVTFLAINTSSITLIPATVISIRMTYGSAAPGEIIGTTVVASTISTVGAVLIDRYYYWKRTRKGGKR
>NZ_AP022557.1|WP_033844098.1|597611_598145_+|spore-maturation-protein
MAIVQLLSTWLIPALIAFILLYGTAKKVPTYETFVEGGKEGIEIAFSLIPYLVGMLVSVAIFRASGALDALMAAIEPFAEAIGMPAEIVPLAALRTISGTAALGMTTDLIATYGPDSFIGRLAATIQGSTETTLYVLTVYFGAVGVKKMGDALKVGVLADILSLIVSFFIVLLVFGR
>NZ_AP022557.1|WP_033844097.1|598263_598995_+|rRNA-pseudouridine-synthase
MERLQKVIARAGIASRRKAEELILQGRVKVNGRVVTELGAKVGPRDDVEVDGIPVEREEPVYYLLYKPRGVISSVKDDKGRKVVTDFFKDLDKRIYPIGRLDYDTSGLLLLTNDGDFAHSLMHPRYEIEKVYVAKVKGIPTGEQLRQLERGVKLEDGMTAPAKVKLLSTDRRKNTAIVEIRIHEGRNRQVRRMFAAIGCDVLKLKRERYGFLDLKGLRPGEYRELTPHEVKLLRAIALSGGRK
>NZ_AP022557.1|WP_033844096.1|599258_599783_+|thiol-disulfide-oxidoreductase-ResA
MKKQQRLVVRTAILLVLLAAVGYTIYANFFTEKTAVAVGSTAPDFVLTDLNGQKHRLSDYRGKGVFLNFWGTWCKPCKREMPYMNEWYPVYKQQGVEILAVNVGEPKLSVKKFAERFGLTFPIVIDQEDQVLNVYNVGPLPTTFLIDKNGKVKQIITGTMTKEDIRRHLESIKP
>NZ_AP022557.1|WP_033844095.1|599796_601455_+|cytochrome-c-biogenesis-protein
MEQVKCECGHVNPHGTAFCESCGKPLQDVGEKPLLDMRYEGSARRSQTYKRTIIDQIWAFFSSVKVGVALIVITLIASAIGTIFPQQMYIPPNADPAEYYEKQYGLAGKLYYELGFNNLYGSWWYILLIALIGVSLVICSLDRVVPLYRALKRQGVKRHPHFLERQRLFGVSRVNDPDDAIATLTERLAKQRYHVREEDGHLLAEKGRFSRWGPYVNHIGLIIFLIGAMLRSVPGMYIDRAMWIPEGETKEIPGTNGRYFLKSEQFIFETYQKGKENEAFNAAIDRVGNGMIAKNYQTNVVLYKRVGPVIAGAEPKLKKVKEYAIRVNEPLKFDGYALYQVDFRLGEPKAMSFQLTDKRSGASFGTVHIDLYNPKEEYDLGRGYRVKLLSYFPDFEFDEDGNPSTKSRVPNNPAFVFKMYAPDRPKGETSFVAIQQTIEPFGDNKYKMAFAGLETRNVSGLTVRRDFTLWILGIGGAIFMIGLIQGMYWNHRRVWVQRVNGELWIAAHTNKNWFGLKNELRRLLDGTGLTMPADRLEEGKKARQGGQAHGTA
>NZ_AP022557.1|WP_033844094.1|601441_602629_+|c-type-cytochrome-biogenesis-protein-CcsB
MVQLSSTLLYTAFILYLIGTFFFGGSIRDRRKEREGKDRWSQLGIAVTIIGFLAQLGYFITRWIAAGHAPVSNLFEFTTFFGMMLVAAFIIIYFIYRLSVLGLFALPVALLIIAYASMFPREISPLIPALQSDWLHIHVTTAAAGEAILAISFVAGLIYLIRVVDQSKPSKRTFWLEVVMFCLITTLGFVVVSTAFGLSGYEAKFTWVDKNKQRDEMIYELPALVGPHEGKLTKDSADRMEPFLEMPAIINAKKLNTVLWSLMAGTVLYIALRLLLRKRIAAALQPWVKNVNLDLADEISYRAVAIGFPVFTLGALIFAMIWAQIAWTRFWGWDPKEVWALITWLFYAAFLHLRLSKGWHGEKSAWLAVIGFAIIMFNLVAVNLVIAGLHSYAGT
>NZ_AP022557.1|WP_033021090.1|602723_603449_+|response-regulator-transcription-factor
MEKQEKTIRILVVDDEERIRRLLKMYLERENYVIDEAGDGNEALEKALANDYDVILLDLMLPGKDGIEVCKEIREQKTTPIIMLTAKGEEANRVQGFEVGTDDYIVKPFSPREVVLRVKALLRRAANAAYAPVETTAKDVLVFPHLTIDNDAHRVTVDGKEVSLTPKEYELLLFLARSPDKVFDREQLLKEVWHYEFFGDLRTVDTHIKRLREKLNKASPQAGKMIVTVWGVGYKFEAVSD
>NZ_AP022557.1|WP_033844093.1|603448_605242_+|HAMP-domain-containing-protein
MWLFRSVVGKLWFTILLLVSCVLFILSILLIKFLEDYYVQEAENDLTRLATKVAEVMHDHRDEELARSIAWTLVDNRTKAIIVADEAHYWYSPGGADSDDVPLSFIRRDRDLRRVLTDGKTVKKRLYMPKWQPKEKLPRDVIMVGVPMTMPDGSRGAVFIYQSLEAIADATKQTKELIFLAAFIAIIMTTFFAFFLSTRITAPLRKMRQAAFEMARGHFDMKVPILTNDEIGGLAMAFNQMGRRLQFNINALNQEKEQLASILSSMADGVITFNRDGEMLITNPPAERFLQAWYFEQGNGGEAMAPLPPQVKELFARVVREEKEQSTEVTLQGRTWVILMTPLYGKTMVRGAVAVLRDMTEERRLDKLRKDFIANVSHELRTPIAMLQGYSEAIIDDIAASEEEKKEMAKVIYDESLRMGRLVNELLDLARMEAGHIELEYEQVKLVPYIERVIRKFYGLAKEKQIELTAEFRDRDIEISLDPDRIEQVLTNLIDNAIRHTESGGTVRLIVEPSGDGVTIHVQDSGSGIPEEDLPFVFERFYKADKARTRGRAGTGLGLAIAKNIVEAHKGLITVHSKLNEGTTFSFYLPNHGSKRT

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Crispr_ID: NZ_AP022557_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_6

851068-851166

Orphan

Consensus_repeat	Method
GGGGCAAGTGAACCAAGTACGGCTAGGAG	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NZ_AP022557_6

>merge|NZ_AP022557|6|851068-851166|CRISPRCasFinder
GGGGCAAGTGAACCAAGTACGGCTAGGAGCCGTTCCATTTCCGCATACCAAAGCGCCAGCTTCAGCCCGAGGGGCAAGTGAACCAAGTACGACTAGGAG

>NZ_AP022557|6|6|851068-851166|CRISPRCasFinder
GGGGCAAGTGAACCAAGTACGGCTAGGAG	CCGTTCCATTTCCGCATACCAAAGCGCCAGCTTCAGCCCGA
GGGGCAAGTGAACCAAGTACGACTAGGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843982.1\|839892_841215_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_AP022557.1\|WP_172418545.1\|859034_859856_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|225806
NZ_AP022557.1\|WP_033843977.1\|848739_851016_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|224126
NZ_AP022557.1\|WP_081897222.1\|853038_853290_+\|spore-coat-protein-CotH	unknown	unknown	gnl\|CDD\|371387
NZ_AP022557.1\|WP_033843967.1\|871047_872550_+\|carboxypeptidase-M32	unknown	unknown	gnl\|CDD\|341054
NZ_AP022557.1\|WP_033843972.1\|866532_866994_-\|DUF4879-domain-containing-protein	unknown	unknown	gnl\|CDD\|374441
NZ_AP022557.1\|WP_033843971.1\|867197_868385_+\|IS701-family-transposase	unknown	unknown	gnl\|CDD\|379252
NZ_AP022557.1\|WP_033843973.1\|866169_866514_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843969.1\|868992_870930_+\|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|224120
NZ_AP022557.1\|WP_051962701.1\|851394_852690_+\|ribonuclease-H-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|225895
NZ_AP022557.1\|WP_033843980.1\|842572_844021_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|183043
NZ_AP022557.1\|WP_033843983.1\|838746_839643_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NZ_AP022557.1\|WP_153017103.1\|841214_842576_+\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NZ_AP022557.1\|WP_033843984.1\|837955_838750_+\|hydroxypyruvate-isomerase-family-protein	unknown	unknown	gnl\|CDD\|163190
NZ_AP022557.1\|WP_033843979.1\|844128_846312_+\|malate-synthase-G	unknown	unknown	gnl\|CDD\|235097
NZ_AP022557.1\|WP_033843978.1\|846484_847702_+\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|235976
NZ_AP022557.1\|WP_033843975.1\|854968_856105_+\|class-I-SAM-dependent-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223194
NZ_AP022557.1\|WP_033017746.1\|854028_854325_+\|cell-division-regulator-GpsB	unknown	unknown	gnl\|CDD\|237616
NZ_AP022557.1\|WP_033843986.1\|836810_837449_+\|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl\|CDD\|198414
NZ_AP022557.1\|WP_033844929.1\|847829_848615_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033843982.1\|839892_841215_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	3.97841e-54
NZ_AP022557.1\|WP_172418545.1\|859034_859856_-\|AAA-family-ATPase	gnl\|CDD\|225806	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion].	2.85742e-37
NZ_AP022557.1\|WP_033843977.1\|848739_851016_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|224126	COG1205, COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only].	0
NZ_AP022557.1\|WP_081897222.1\|853038_853290_+\|spore-coat-protein-CotH	gnl\|CDD\|371387	pfam11122, Spore-coat_CotD, Inner spore coat protein D. This family is conserved in the Enterobacteriaceae family. CotD is an inner spore coat protein that is expressed in the middle phase of mother cell gene expression. Along with CotD, CotH, CotS and CotT it is assumed to assemble into the loose skeleton of the matrix, between the shells of SpoIVA and CotE. Coat proteins do not share much sequence similarity between species, but this does not imply they do not share secondary, tertiary, or quaternary features.	5.24149e-12
NZ_AP022557.1\|WP_033843967.1\|871047_872550_+\|carboxypeptidase-M32	gnl\|CDD\|341054	cd06460, M32_Taq, Peptidase family M32, which includes thermostable carboxypeptidases TaqCP, PfuCP and FisCP. Peptidase family M32 is a subclass of metallocarboxypeptidases, distributed mainly in bacteria and archaea, whose members contain a HEXXH motif that participates in coordinating a divalent cation such as Zn2+ or Co2+. It includes the thermostable carboxypeptidases (E.C. 3.4.17.19) from Thermus aquaticus (TaqCP) and Pyrococcus furiosus (PfuCP), which have broad specificities toward a wide range of C-terminal substrates that include basic, aromatic, neutral and polar amino acids. These enzymes have a similar fold to the M3 peptidases such as neurolysin and the M2 angiotensin converting enzyme (ACE). The keratin-degrading extremophilic eubacterium Fervidobacterium islandicum M32 carboxypeptidase (FisCP) plays an important role in cellular metabolism, and significantly enhances the degradation of native chicken feathers. It has been shown to mainly cleave the C-termini of peptides with a basic amino acid sequence. Novel M32 peptidases from some eukaryotes: protozoa Trypanosoma cruzi, a causative agent of Chagas' disease, and Leishmania major, a parasite that causes leishmaniasis, have been identified, thus making these enzymes an attractive potential target for drug development against these organisms.	0
NZ_AP022557.1\|WP_033843972.1\|866532_866994_-\|DUF4879-domain-containing-protein	gnl\|CDD\|374441	pfam16219, DUF4879, Domain of unknown function (DUF4879). family of short proteins of bacterial proteins of phage origin, exemplified by protein SPBc2p013 from Bacillus phage SPBc2, found in various Bacillus and Pseudomonas species. Structure show unexpected structural similarity to greek key beta barrels from the E-set domain, especially to domains involved in carbohydrate and protein- protein binding. However functional consequences of this similarity are not confirmed.	6.6668e-12
NZ_AP022557.1\|WP_033843971.1\|867197_868385_+\|IS701-family-transposase	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.009e-13
NZ_AP022557.1\|WP_033843969.1\|868992_870930_+\|ATP-dependent-DNA-helicase	gnl\|CDD\|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	3.65988e-118
NZ_AP022557.1\|WP_051962701.1\|851394_852690_+\|ribonuclease-H-like-domain-containing-protein	gnl\|CDD\|225895	COG3359, COG3359, Predicted exonuclease [DNA replication, recombination, and repair].	5.50552e-77
NZ_AP022557.1\|WP_033843980.1\|842572_844021_+\|FAD-binding-protein	gnl\|CDD\|183043	PRK11230, PRK11230, glycolate oxidase subunit GlcD; Provisional.	8.72924e-178
NZ_AP022557.1\|WP_033843983.1\|838746_839643_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	7.06995e-93
NZ_AP022557.1\|WP_153017103.1\|841214_842576_+\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	1.0593e-93
NZ_AP022557.1\|WP_033843984.1\|837955_838750_+\|hydroxypyruvate-isomerase-family-protein	gnl\|CDD\|163190	TIGR03234, OH-pyruv-isom, hydroxypyruvate isomerase. This enzyme interconverts tartronate semi-aldehyde (TSA, aka 2-hydroxy 3-oxopropionate) and hydroxypyruvate. The E. coli enzyme has been characterized and found to be specific for TSA, contain no cofactors, and have a rather high Km for hydroxypyruvate of 12.5 mM. The gene is ofter found in association with glyoxalate carboligase (which produces TSA), but has been shown to have no effect on growth on glyoxalate when knocked out. This is consistent with the fact that the gene for tartronate semialdehyde reductase (glxR) is also associated and may have primary responsibility for the catabolism of TSA.	4.38737e-131
NZ_AP022557.1\|WP_033843979.1\|844128_846312_+\|malate-synthase-G	gnl\|CDD\|235097	PRK02999, PRK02999, malate synthase G; Provisional.	0
NZ_AP022557.1\|WP_033843978.1\|846484_847702_+\|malate-dehydrogenase	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NZ_AP022557.1\|WP_033843975.1\|854968_856105_+\|class-I-SAM-dependent-RNA-methyltransferase	gnl\|CDD\|223194	COG0116, COG0116, Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair].	1.4708e-179
NZ_AP022557.1\|WP_033017746.1\|854028_854325_+\|cell-division-regulator-GpsB	gnl\|CDD\|237616	PRK14127, PRK14127, cell division regulator GpsB.	5.17211e-52
NZ_AP022557.1\|WP_033843986.1\|836810_837449_+\|Bax-inhibitor-1/YccA-family-protein	gnl\|CDD\|198414	cd10432, BI-1-like_bacterial, Bacterial BAX inhibitor (BI)-1/YccA-like proteins. This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.	1.49597e-36
NZ_AP022557.1\|WP_033844929.1\|847829_848615_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	4.19836e-97

>NZ_AP022557.1|WP_033843977.1|848739_851016_+|DEAD/DEAH-box-helicase
MKKQTLSEWMEQLRQDPHVVYWHEIEPKEADTVPFPAELDARVRLALEARGIASLYTHQAAAYEAARGGRNVVAVTPTASGKTLCYNLPVLDAIAKAPESRALYLFPTKALAQDQMHELHEIIAEMEAPIYTYTYDGDTPPVLRQKIRQAGHIVITNPDMLHTAILPHHTKWISLFEQLRYVIIDELHTYRGVFGSHVANVIRRLKRICAFYGSSPTFICASATIANPQQLAERLTGEPMTLIDQNGAPQGRKWFVLYNPPIVERTMNVRQSAAKTAVELARQLLFNRIPTIVFARSRVRVELILSHLQAALRSRGGETAVRGYRGGYLPNERRAIEKGLRSGEVLGVVSTNALELGVDIGQLQACVMAGYPGTIASTWQQAGRAGRRHGDSLVVLVASSNPLDQYMISHPEYLFARSPETARINPDNLLILVDHLKCAAYELPFRRGETFGGVEVEEVLDFLTEQGVLNERAGRWHWMSDAFPAHDVSLRSAAQENVVIIDRSETARPRVIGEMDRFSAMTLLHEEAIYLHEGTQYQVEKLDWEEKKAYVRQVDVDYFTDANLAVRLDVLSEDRRQTNGSMVVRYGDVSVRAMATIFKKIKLSTFETIGSGPIRLPEETIHTSAAWVEWETVPPQFSPAQFEQLLVSMANVLGHLVPVFVMCDRSDIHVVPQLKAPHSGRPTIFLYDHYPGGVGLSEAVFERWTEIVERVRQWVEHCPCADGCPSCIGVSSAALPSVKRQLVAFLREQMAAWLPSSV
>NZ_AP022557.1|WP_033844929.1|847829_848615_+|IclR-family-transcriptional-regulator
MEKEHTVKSVRRALQIIEIVSAKKDGLGVTEIAKQMDINKSSVYRILTTLAQYGYIEQHPETERYKLGYKFLELSSKLLDSIDLRQEAKPYLRQLEKETNEVIHLVVYDQGEVIYIEKLEGTETLRMHSKVGKRAPMHCTAVGKAILAHLPPAVAAEIIERKGLPKHTDRTITNREAFFRELEIVRQNGYALDLEENEYGIRCVAVPIFDYTGSVVAAISVSGPTIRMTDDRISDLAVRMRQLGSELSARLGCRQPHSVQL
>NZ_AP022557.1|WP_033843978.1|846484_847702_+|malate-dehydrogenase
MENLRERALLVHRQARGKLSVEVKVPVVNANDLSLIYSPGVAEPCKEIYVDQDEMYNYTVKGNFVAVVSNGTAVLGLGNIGARAALPVMEGKAALFKAFAGIDAVPLCLDTEDPDEFIQAVKLLEPTFGGINLEDIAAPACFVIEERLRQEMAIPVFHDDQHGTAIVVAAGLANALKAVGKTLADCRVVINGAGAAGVAIAKLLLSMGVGELIVCDTKGAIYAGRPHGMNVIKEEIARHTNHRRISGTLADVIQGADVFIGVSVAGALTPAMVRTMNRNAIVFALANPVPEIMPDEAKAAGAAVVATGRSDLPNQVNNVLAFPGIFRGALDVRATQINEAMKIAAAKAIAGLIRPEELTEEYVIPNPFDRRVVEAVASAVARAAMETGMARVKEKAEEQNRVREG
>NZ_AP022557.1|WP_033843979.1|844128_846312_+|malate-synthase-G
MAEYVQTGTIQVAKVLYDFVNEELLPNSGVNQDKFWRDFGALIADLTPRNKALLARRDEIQTQLNEWHKAHRGRFDFNEYKSFLTDIGYLEPEVEDFEITTDNVDDEIAVQAGPQLVVPLTNARYALNAANARWGSLYDALYGTDAISEEDGAERGSSYNPVRGAKVIAYGRQFLDEAVPLAQYSHKDAVQYAIVDGQLVVTIEGGATTGLKEPEKFVGFQGEPQRPTAVLLKNNGLHIEIQIDREHPVGKTDQAGVKDIVLEAAVTTIMDGEDSVAAVDAEDKVVVYRNLFGLIKGDLTATFEKNGKMMTRALNPDRVYKTPDGGELVLPGRSLMFVRNVGHLMTNNAILDANGEEVHEGIIDAVITSLIMKHSLIGNTRYLNSRKGSIYIVKPKMHGSAEVAFANELFDRVEDLLGLERNTIKIGVMDEERRTSLNLKNCIYQVRDRIVFINTGFLDRTGDEIHTSMEAGPMLRKNGMKSSTWLQAYEKSNVAVGLAAGFRGRAQIGKGMWAMPDLMAEMLKQKGAQLKAGANTAWVPSPTAATLHALHYHQVNVAAVQNELANERRDYRDDILQIPVVDNPQWTAEDIQEELDNNCQSILGYVVRWIDQGIGCSKVPDIHNIGLMEDRATLRISSQILANWLHHGICTKEQVLETLKRMAKVVDEQNAGDPNYRPMAPNYDDSVAFQAACDLIFLGYEQPNGYTEPILHRRRQEAKAKFAAVEQ
>NZ_AP022557.1|WP_033843980.1|842572_844021_+|FAD-binding-protein
MRKRPIATNDPHIQALAGIVGETAILYRKEDLIAYDCDGFTVHRHLPRAVVFPNSTEEVAAIVNYCHKHDLPFLARGAGTGLSGGAIPLNGEVVISLTRMKRLLHVDLENRRAVVEPGFVNLKLTNSVAHRGYYYAPDPSSQYCCTIGGNVAENAGGAHCLKYGVTTSHILGLEVVLPTGEVIEIGGNGVLDPPGYDLLGLLTGSEGTLGIVTKITVRLLKNPEAKQTVLAYFDEVEDASQTVSDIISAGIVPAALEMMDQTAIEAVEAAAFPVGHPKDIAALLLIEVDGISAGIDEQINDILTICRRHRVREVKVAQSEEERARWWANRKTGFGAMGAISPDYLVQDGVIPRSRLPEVLREIAAISRRYGLRIANIFHAGDGNLHPLVLFDASKPGETERALAAGSECLKACAAVGGSITGEHGVGIEKKEEMRFIFTDEEILAQTAIRDVFNPKNLLNAGKLFPTPGRCVETKQAPLPVK
>NZ_AP022557.1|WP_153017103.1|841214_842576_+|(Fe-S)-binding-protein
MMNAMTSERTGSPACATASLGNYRFADLPDPSKWADCVHCGMCLESCPTYEQTGQEQHSPRGRVHLMKSVGEGKLDLTLDLLDPIFTCLDCRACTTACPADVDVGGLIEQVRGQLRQAVPLTGWKAFVSDFFLKGVFPHPSRLDWLGRLLKLYQKSGLQTVARKTGLLRVMPDHLAEMEAVLPEVGTPVRKKYKRAPLIKAKGETKRTVAILTGCVMDVMFSDINEATIRVLARNGNDVVIVPNQTCCGALHVHAGDRETGRKLARQNIEAFQHVDHVIVNAAGCGCMLKEYPELFRDDPKWHEKAEQFAAKVEDVSKFLHDTGFERPRAELNVRLTYHDACHLAHGQGIRQEPRALLESIPGVEMVAMPNADRCCGSAGIYNITHPEMAQAVLESKMQHVPQEVELISMGNPGCMLQMALGVMKHGRNQKIVHTVQLLDWAYQKEEGKDVRI
>NZ_AP022557.1|WP_033843982.1|839892_841215_+|FAD-binding-oxidoreductase
MLSLAWLEELQAFLHSEQIKRNETFHPLGNDGAVTVYPQTEEEIAAVLRYADRHGKKVAIAGRGTKRGFGGQRAQVDILLSLERYAGIVEHAAADMTVTVKAGTVFGELQRALAPYRQKVALDPFWPEEATIGGVIAANDSGPKRLSYGAARDSVIGLRVVYPDGTVIRSGGKVVKNVAGYDMNKLFIGAMGTLGVLSEITFKLRPLAKYESIVLLSFPSGDLHDVRSFAVSFLDTMMEPICFELLNPALAERLTGRPVYTLVIGFEDVESAVHYQEQSVERLRPQTAEMAVFAGAEASAFWRTFYTVAPNGRLAPAENGVEAAVKIGVVNLDVLSVLRESALIADRCHVRLEAHGGLGHGLCQAYVRGGEKDVLTAIEELRQTAVRLGGYAVVKHLPFSLRQRIDVWGGKPSYVFLLEGIKRKVDPNKTVNDQRFIGGI
>NZ_AP022557.1|WP_033843983.1|838746_839643_+|NAD(P)-dependent-oxidoreductase
MTRVGFIGLGVMGSRMARRLLEAGFNVTVYNRTPEKAVPLVNLGAQQAATVAELAGGADVICTCLSMPDDVINMYTGEGGILEAARPGTVCLDFTTVGPKTSRLVAERARQRGVAYLDAPVSGGPEGAEQGTLTMMVGGDQAAWEQARPLLGALGKTVEYLGESGAGSAAKAINQYLVAVHSVAAAEAMVAGVAYGLDAGKLYRLLKESYGDSRMLRRHMEQFVLPRRFTPGGAMKYVHKDVRLANELMDEIGLGRRLGIPAEKAFAEAIAAGLADLDMSAVIQLLEQRVGVMVKETE
>NZ_AP022557.1|WP_033843984.1|837955_838750_+|hydroxypyruvate-isomerase-family-protein
MKFAVNVSTVFTETPFLARFAKARQHGFSLVECQFPYAAAPEAIACELEAHELSLLLINLPAGDWEKGERGLAIFPDRHEAFQRALEEGLRYAVELGVPHLHCMAGVVPKEMAREQAKETYMRRIDEAAAALAVHGLTLMIEPINPFDMPGYFLTDIAEAAAIIRDLGRPNIKLQYDIYHMARLGFDVAAMFAAYEPLIAHVQFADAPGRHEPGTGALPYREMFAFLQKRGYNGAIGLEYIPSRESSESLGWYEEYRRQEGGGR
>NZ_AP022557.1|WP_033843986.1|836810_837449_+|Bax-inhibitor-1/YccA-family-protein
MNHSTVYRPHSPVAKLAVSFLVALAVATAGLYAGQWVPAGLYLPLYALELILLLVMIFARSKKAVGYPLMFAFMFVSGATLYPLIGYYISIIGAAAVFKAFALAVVSFTGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIQWFIPFSSVGQMGVAALGILIFLGFTIYDINRLARYGFTEADIPMIVVNIYLDFINLFVYILRFFASDDD
>NZ_AP022557.1|WP_051962701.1|851394_852690_+|ribonuclease-H-like-domain-containing-protein
MKPKLSQWKELLAARHQSKRPADENEEAAKQRSDVPYVDLWQEYGVKPYWYEGDYCLVRETSYPLAWPHGRYRLGDLHDVHRRWQEAPFSHPLSCRGLAVSDLFFFDTETMGLSSGVGNVMFLLGHARVLGDRVVVRQHVLPYPGAEAALYQSFLSDVDYTTLVTYNGKAFDWPRLKTRHALVRDVVPRLPSFGHFDLYHAARRLWKDALDSLRLEEVERSLLSIERGEDVPGFLAPMMYKEFLHTPHPDRMMPILRHNENDVLSLISLYIHLSIQLLEAAQLADPREQLAAARWLEAVGETAAARNVYEQASGKETKEAEAAKWQLSLLYRREKRYEEAAAIWRDLLAGGNAHWKVKAALELAKAYEHHFRDAKEAHRYAVMAYEAWRPLARASRERSEKEEMEWRKRLARLERKKAKSSFAHFPGKRKM
>NZ_AP022557.1|WP_081897222.1|853038_853290_+|spore-coat-protein-CotH
MHCPPHVTAPIVHPPQCCVQHHFQATIVPHIHPSHTTHVYHHLYEHQHYFPHTESAVAQAANRHVYCPAPMPGWGPFPAPPMR
>NZ_AP022557.1|WP_033017746.1|854028_854325_+|cell-division-regulator-GpsB
MSAQRVKLTPKDILEKEFRVSMRGYNQDEVDQFLDLIIKDYEAFQQEIDELRQENARLKRQVEELQKRPAVSAGTTNYDILQRLSNLEKHVFGRKLYE
>NZ_AP022557.1|WP_033843975.1|854968_856105_+|class-I-SAM-dependent-RNA-methyltransferase
MTSFSLIATAAMGLESVVADEVRRLGYDCQVENGKVTFEGDALAICRANLWLRAADRVKLKVGEFRATTFEELFEQTKALPWADYLPKDAEFPVIGKSVKSTLFSVSDCQAIVKKAIVESLKERYHLSWFPETGPLYRIEVALHKDIATLTIDASGAGLHKRGYRVRQGEAPLRETLAAALVLLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAPGFNRDFVSEQWPWIGERAWERARQEVEDMARYDEPLDICGIDLDPRMVDMARANAAEAGLADLISFQTGRAEQFRTDKSYGVIVSNPPYGERLGERREVEALYRAIGRTFTALDTWSVYILTAHRGFETHYGRPATKRRKLFNGFIETHYYQYWGPRPPRKC
>NZ_AP022557.1|WP_172418545.1|859034_859856_-|AAA-family-ATPase
MYFFLHFSAFFACKKQREPFAKETAPSEAYQGAAFQEALRALEYVKRTRGIGLLTGEPGAGKTFALRAWKESLSPSLYHVVYFPLSTGGVMDVYRGLALGLGEEPKYRKVDLFRQIQQAIERLYHERRITPVLILDEMHFAKDAFLQDIAILFNFEMDSTNPFVLMLAGLPHLQGKLRLNQHRPLDQRIIMRCRMGPLEKEEVAGYIEHRMKQAGAKHPIFTPSALEAIALQSRGWPRVINTLATTCLLYGHQLKKDVIDEEVVRMATEEMGY
>NZ_AP022557.1|WP_033843973.1|866169_866514_-|hypothetical-protein
MNINKAAFAAYTQLTLGAKFRNHIRNGEPFGGREGQNKSMDFIEFQKALEEDKVVNKNLSRETSKYHKQILEDKLKYSTNVFFSTEVAEIVNKAFKLGLVGNDEYLISKYEERV
>NZ_AP022557.1|WP_033843972.1|866532_866994_-|DUF4879-domain-containing-protein
MKKVFGFLFAIAFVFTLNHNEAKAAPAPPLTDLQIIGVTSDGANYEWEYISFDQTSASYPMSGETGYIAVYVEGTELYGWFRIYNKGQDITNIAKEIIDMREPVTDSSGMVIGWIKYYEIPLDKVESGQFTVSARNYYPPNNTFYDNLYINVE
>NZ_AP022557.1|WP_033843971.1|867197_868385_+|IS701-family-transposase
MNRLAHHQGIHKFFMTLGLALYFSKPVIKHLVYLVDALTTKGFSGTLTDVGYWSFHPNHRTTLSHFFTKSPWNEEKLLEKLQEWILRQIERLAKQENQPLFVSIDDTICQKTKPSSRAAHAIQGCDWHYSHKDHQSVWGHSLVWLMVHTFTQAFPFAFRLYDKAAGRSKIDLAIEMLSSLKGKWAQPVYVLMDSWYPSQALIEACLKQGFHVIAMLKTNRILYPKGIAIQAKEFARYIEPQDTRFVTVGKERYRVYRYEGAIRGLDDAVVLLAWKADEPMTPDHLHVVLSTDRELSDEDILRYYAQRWTIECFFRQAKDQLKLDGYRVRHVRAVKRYWVVVLFACVYSIAESQQDLSSGLELLRSRKGHSVVEFIYDAAKQDIPIDVIKKQLHVA
>NZ_AP022557.1|WP_033843969.1|868992_870930_+|ATP-dependent-DNA-helicase
MSHQRYPFALEKNENFFDKLSQWIGDVFYDILPEAGFELRDEQIYMAFQLERAFREKKVIFAEAGVGTGKTIVYLLYAICYARYTGKPAIIACADETLIEQLVKKEGDIAKLSEVLGLDIDVRLAKSPDQYLCLNKLEEVTTYLDEDIELYEQIYDELPAFVHDYQPMQSFYRYGDRKEYAHLTDEQWKKIAWDPFQDCFTCEKRHRCGQTLWRDYYRKAADLIVCSHDFYMEHVWTYEARRREGQLPLLPEASCVVFDEGHLLEFAAQKALTYRMKETTLETLLTRLLENDIREELAYAIEEALAASSRFFAELKACAKDVPGSNRKEIVSSPKLQQWAKKLRSKIVEIGNELVFESETYTIDHYQLNIVDEYLDQIQYSLDLFLTNTDAITWLESSRHEATFVVMPRTVQEVLREKVFSKRMPFVFSSATLSNGKSFEYIAQSLGIDDYLSFSVPSPFDYDEQMAIYMPTFRADETLFAKKYEYALNKLRETGGRALLLFPTREELLEFKEAAAGEPFSFLFEGDREISDLVAEFQRNEETVLCSEHLWEGLDIPGPSLSNVIIWSLPYPPNDPVFQAKRKAYRNPFWDVDVPYMLLRLRQGVGRLIRTRDDRGLVSIFITDREDGRVVASIKDVLPTTVREE
>NZ_AP022557.1|WP_033843967.1|871047_872550_+|carboxypeptidase-M32
MKQIEEQFLRYVKKMMSYREAIGLMYWDLRTGAPKKGVEQRSEVIGMLSEEVFHMSTSEEMAAFIAKLSPQGVYEQLDEVTQRTLDECKKEYERNKKIPADEYKEYVILCSKAESVWEEAKATADFALFRPYLERIVEFQRRFISYLGYEEHPYNTLLDQYEPGMTVELLDGLFGQLRERIVPLVQVVSSAPDKPDTSFLFAPFPKEKQRAFLLELLVELGYDFGKGRLDETVHPFAIGLNPNDVRITTRYDERDFRTAIFGTIHECGHALYEQHISEALTGTPLASGASMGIHESQSLFFENMIGRHYAFWKRNYPRLQQYAPAQFAGVSLDAFYRAINEAKPSLIRIEADELTYPLHIIIRYEIEKQLFAGELEAADLPDVWNAKYEQYLGIRPHNDSVGVLQDVHWSGGSFGYFPSYALGYMYAAQLKRAMEKELDFAQLLEEGTIAPIREWLTDRIHRFGKTKKPLDLVRDATGEPLKADGLIQYLEEKYQALYRL

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Crispr_ID: NZ_AP022557_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_7

889768-889861

Orphan

Consensus_repeat	Method
GTTTTTGATGAATAAAGTAGCTAGTAGGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_7

>merge|NZ_AP022557|7|889768-889861|CRISPRCasFinder
GTTTTTGATGAATAAAGTAGCTAGTAGGCTTAGCTTTGTCGGAATCGATTGGTTTCACAGTTTCGTTTTTGATGAATAAAGTAGCCAGTAGGCT

>NZ_AP022557|7|7|889768-889861|CRISPRCasFinder
GTTTTTGATGAATAAAGTAGCTAGTAGGCT	TAGCTTTGTCGGAATCGATTGGTTTCACAGTTTC
GTTTTTGATGAATAAAGTAGCCAGTAGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843949.1\|897586_898693_-\|DUF2515-family-protein	unknown	unknown	gnl\|CDD\|371209
NZ_AP022557.1\|WP_081897220.1\|893639_894092_+\|stage-III-sporulation-protein-AH	unknown	unknown	unknown
NZ_AP022557.1\|WP_033019954.1\|896100_896334_+\|YozE-family-protein	unknown	unknown	gnl\|CDD\|184229
NZ_AP022557.1\|WP_165570942.1\|889601_889748_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418546.1\|886351_886501_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033021412.1\|888706_889114_+\|hotdog-fold-thioesterase	unknown	unknown	gnl\|CDD\|161843
NZ_AP022557.1\|WP_033843952.1\|891220_891814_-\|DUF502-domain-containing-protein	unknown	unknown	gnl\|CDD\|225480
NZ_AP022557.1\|WP_011231056.1\|887444_887588_+\|acid-soluble-spore-protein-N	unknown	unknown	gnl\|CDD\|236496
NZ_AP022557.1\|WP_081897221.1\|887257_887389_+\|FbpB-family-small-basic-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033021406.1\|886613_887135_+\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_AP022557.1\|WP_033021409.1\|887964_888381_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NZ_AP022557.1\|WP_033843950.1\|894838_895852_+\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NZ_AP022557.1\|WP_033843951.1\|891988_893428_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225307
NZ_AP022557.1\|WP_033021411.1\|888395_888710_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033021414.1\|889138_889429_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227178
NZ_AP022557.1\|WP_033843948.1\|898852_899170_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033021407.1\|887617_887845_+\|small-acid-soluble-spore-protein-Tlp	unknown	unknown	gnl\|CDD\|179658
NZ_AP022557.1\|WP_033019961.1\|896487_897135_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033021416.1\|890106_891045_+\|magnesium-transporter-CorA-family-protein	unknown	unknown	gnl\|CDD\|213361
NZ_AP022557.1\|WP_033019951.1\|897358_897538_+\|YozD-family-protein	unknown	unknown	gnl\|CDD\|316666

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033843949.1\|897586_898693_-\|DUF2515-family-protein	gnl\|CDD\|371209	pfam10720, DUF2515, Protein of unknown function (DUF2515). This family is conserved in Firmicutes. Several members are annotated as YppC. The function is not known.	3.21399e-155
NZ_AP022557.1\|WP_033021412.1\|888706_889114_+\|hotdog-fold-thioesterase	gnl\|CDD\|161843	TIGR00369, Putative_esterase, uncharacterized domain 1. Most proteins containing this domain consist almost entirely of a single copy of this domain. A protein from C. elegans consists of two tandem copies of the domain. The domain is also found as the N-terminal region of an apparent initiation factor eIF-2B alpha subunit of Aquifex aeolicus. The function of the domain is unknown.	1.01509e-40
NZ_AP022557.1\|WP_033019954.1\|896100_896334_+\|YozE-family-protein	gnl\|CDD\|184229	PRK13672, PRK13672, hypothetical protein; Provisional.	1.74536e-31
NZ_AP022557.1\|WP_011231056.1\|887444_887588_+\|acid-soluble-spore-protein-N	gnl\|CDD\|236496	PRK09398, sspN, acid-soluble spore protein N; Provisional.	1.55045e-14
NZ_AP022557.1\|WP_033843952.1\|891220_891814_-\|DUF502-domain-containing-protein	gnl\|CDD\|225480	COG2928, COG2928, Uncharacterized conserved protein [Function unknown].	1.04516e-30
NZ_AP022557.1\|WP_033021406.1\|886613_887135_+\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.43996e-46
NZ_AP022557.1\|WP_033021409.1\|887964_888381_+\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	1.51797e-45
NZ_AP022557.1\|WP_033843950.1\|894838_895852_+\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NZ_AP022557.1\|WP_033843951.1\|891988_893428_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|225307	COG2509, COG2509, Uncharacterized FAD-dependent dehydrogenases [General function prediction only].	0
NZ_AP022557.1\|WP_033021414.1\|889138_889429_-\|hypothetical-protein	gnl\|CDD\|227178	COG4841, COG4841, Uncharacterized protein conserved in bacteria [Function unknown].	1.05961e-34
NZ_AP022557.1\|WP_033021407.1\|887617_887845_+\|small-acid-soluble-spore-protein-Tlp	gnl\|CDD\|179658	PRK03830, PRK03830, small acid-soluble spore protein Tlp; Provisional.	2.60702e-22
NZ_AP022557.1\|WP_033021416.1\|890106_891045_+\|magnesium-transporter-CorA-family-protein	gnl\|CDD\|213361	cd12827, EcCorA_ZntB-like_u2, uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family. A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.	5.3614e-143
NZ_AP022557.1\|WP_033019951.1\|897358_897538_+\|YozD-family-protein	gnl\|CDD\|316666	pfam14162, YozD, YozD-like protein. The YozD-like protein family includes the B. subtilis YozD protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	8.07316e-17

>NZ_AP022557.1|WP_165570942.1|889601_889748_+|hypothetical-protein
MNKKRPFAPSYESDGVMGKNSKTHPHRSERQPTGKQAPDFFNTTPSSE
>NZ_AP022557.1|WP_033021414.1|889138_889429_-|hypothetical-protein
MNIVITKKAFDWYKRELGLKPGDAIRFFARYGGCGTVQKGFSLGMAKDEPAGEPAAQTTIDGVTFFVDDSDQWYFDGRDLTVDLDETGDEPVFLLQ
>NZ_AP022557.1|WP_033021412.1|888706_889114_+|hotdog-fold-thioesterase
MIDLTAVKEMAKHTLIDTLGIELVELGEGRVVATMPVDQRTHQPAGLLHGGASVALAETVASIGAYALVDPQTENVVGLEINANHVRAVRSGTVTATGTVLHRGRTTMVWDIRITDEQGQLVCVSRCTIAIIRKS
>NZ_AP022557.1|WP_033021411.1|888395_888710_+|hypothetical-protein
MAFGIRRHELEAWKEKVKRGEIAFLTHYWYDERFPDCTTVTKVGCADIAQLTAWGRQYGLKEEWIDRRGEFPHFDLLGETQRRVLRQEGRLFELERFTKRGKKR
>NZ_AP022557.1|WP_033021409.1|887964_888381_+|acyl-CoA-thioesterase
MKVVEKQIEVRYAETDQMGVVYHANYLVWMEVGRTELIKQLGFHYAEMEKEGIISPVIDLQVSYKKPLHYGETATVRTWIDAYDGIRVTYGYEILAPDGEVAVTGKSQHVCVKRETFRPIVIRKYFPAWHEAYERAKR
>NZ_AP022557.1|WP_033021407.1|887617_887845_+|small-acid-soluble-spore-protein-Tlp
MPRPKPDDRSDNVEKLQEMVQHTIENMEKAEETMQFASPEERKKIAEKNRRREEAIAAMRAEIKDEAAAREHGYQ
>NZ_AP022557.1|WP_011231056.1|887444_887588_+|acid-soluble-spore-protein-N
MSNPKGSRKHFVPNHIGTQPRAAGGNKGKQMQDQSGQHAQVIQTKGE
>NZ_AP022557.1|WP_081897221.1|887257_887389_+|FbpB-family-small-basic-protein
MRRSRKMTLQELISENKRQLLNDREALEKIEKRLEERMLKKAE
>NZ_AP022557.1|WP_033021406.1|886613_887135_+|TlpA-family-protein-disulfide-reductase
MRKWFVLLLFLAVAGYGLWNAMAAGKTNEAVAAGPRVGHPAPDLALPTLGGEPVKLSAWRGKAVVLNFWTSWCPPCKEEMPELEKFYKQHGHEVAVLAVHLTTRDTLDNAERFAKSRNLTLPVALDVRGEAFYHYRVQTIPTTYIIDPNGVIRKKIVGPVTAARLENATALFR
>NZ_AP022557.1|WP_172418546.1|886351_886501_+|hypothetical-protein
MGRTKLGNANAQRNNNAKKKNDFNEWTSEFASYAEVEAEKMKNDHQNIR
>NZ_AP022557.1|WP_033021416.1|890106_891045_+|magnesium-transporter-CorA-family-protein
MMKMYLSDASGKMREIDRIENGCWINLVAPTEEEIRYIAHHLDIPIDSIKDALDDEERSRIEKEDNHVLIIVDIPIVAHDEVDGPMYETIPIGMIITNTCFITVCLQENPIFEEFSKNKIKNFYTFMKTRFALQMLYMISTYYLRYLKQINRRTSEIEKELHQSMKNKELFSLLSMEKSLVYFMTSLKANNIVMERLLRLNYLRMYEDDQDLLQDVIIENKQAIEMAEVYSSILSGMMDAFASVISNNLNIVMKFLTAITIVISLPTMVASFYGMNVPIPYQHSPYAFLIAMALAGSLSAATAYVFWKKRYF
>NZ_AP022557.1|WP_033843952.1|891220_891814_-|DUF502-domain-containing-protein
MRFFMKNFVNGMLTIVPILLAVYVCYKVFAMLDGLLGQYVRPYLDGRYIPGLGLLATVALITVCGWLSTQYVSGRLIRLAGRLLESIPLMKTVYSVAKDTIASFVGEKRSFSQVVLITVPESGWKCLGFITMDDVGAWHDPLADYVAVYIPQTFQVAGLTLLVPKEQVEVIDIAPEEAMKFILSGGVAARKQKRLPE
>NZ_AP022557.1|WP_033843951.1|891988_893428_+|NAD(P)/FAD-dependent-oxidoreductase
MNNHYDVIVVGAGPAGIFTCYELTRKLPRANVLLIDKGHDIYKRNCPILQKKIEKCPPPAGKKDYAGCVPACSITNGFGGAGAYSDGKFNITSEFGGWMTDYLPASTVLELIRYVDEINLKHGATTSITDPMTDKVKEIERRAYAAGLKLLRAYVRHLGTEQNLEILKSIFEYLRERIAMRFTTEVEDIVTERTESGHRVKGVMLKNGETLTAEKIVIAPGRDGSVWLSKILRKRRLRMINNQVDIGVRVETSNIVMQEINEHLYEGKFIFNTSVGTQVRTFCSNPSGHVVVENHSGIMLANGHAYKDPKLGSDNTNFALLVSHKFSDPFDKPNEYAHEISRLANALSNGGIIVQKYGDILKGRRSTEKRIKEGFIEPTLKEAVPGDLGLVLPYNTMKSLIEMTEALNHVTPGLASEHTLFYGVEAKFYSARPKLNDRFETEIAGLYVGGDGAGITRGLAQASACGVWIARDIVEKLGK
>NZ_AP022557.1|WP_081897220.1|893639_894092_+|stage-III-sporulation-protein-AH
MIVIKQNPEKDVYRNLLDLSFEICDQFHLVLRKDMGPLTTYEPILKRLENSLIVMKEESEWASTILGSGQTALVYYYRTDANANKVLTEVTNSLYDWVQPHLPEDLSFFKQGKEWLVTISHEKESYIYTEDEYEIKKVMGIKGLKLEIDR
>NZ_AP022557.1|WP_033843950.1|894838_895852_+|biotin-synthase-BioB
MGNWIELAERVLAGHELTDDEALAILDCPDEELLALMQGAYHIRRAYYGNKVKLNMIINAKSGLCPENCGYCSQSSISTAPVQTYKMVNKETLIRGAEEAYRLQIGTYCIVASGRGPSDKEIDIVVSAVKEIKERFGLKVCACLGILKPEQAARLKEAGVDRYNHNINTSKEHHPNITTSHTYDDRVRTVETVKEAGISPCSGVIIGMKETKRDVVDMARSLRALDADSIPINFLHAIDGTPLAGTNELNPRYCLKVLALFRYINPTKEIRIAGGREVNLRSLQPLGLYAANSIFVGDYLTTAGQEKSADYQMLEDLGFEIEFAPAPQAEVGEKAWI
>NZ_AP022557.1|WP_033019954.1|896100_896334_+|YozE-family-protein
MEKTFYRYLLRFRYGHAEDPIVRFANGAYADHSFPKGSVDYEELSGYLELNGDYLESMAVFDELWEQFVYEASPRAR
>NZ_AP022557.1|WP_033019961.1|896487_897135_+|hypothetical-protein
MSAPKRPKFSIGDVVVNTLYGTVGTVTGIQQVDGTFLYEINHSHSLFAEQALVALSEFAGDLWIVEEVEIELPFFLGEIVRVRDYGGHLFKVVGVRTEIYRYYGEGWEETIYELKRLTDGWEIEVPLEDIIPVALGEETSVTLVQDIVIAMPALWPLPADNRSSGPSVDELLDVYNDYKALYEWFGDEQYKQMMETVVQRLRTIVNHQNIETDKG
>NZ_AP022557.1|WP_033019951.1|897358_897538_+|YozD-family-protein
MKEIEVVIDTEEIAEFFYEQLIRRGFVPTQEELAELADITFDYLLEKCLIDEEIDVDDE
>NZ_AP022557.1|WP_033843949.1|897586_898693_-|DUF2515-family-protein
MPFHPLDWLRHPLQHAYRSFLYRHPVRLADAGLLHELIARRAARPPRPARPEEEAIIAAIRRATAEQNRNNVTRTAAYLAMFERYPELHWALLAHLVSRNGGWNMTDLRGGLLPRLLSNEMIAPLFLFLERANALIFHDAYPQLLLYAESKRRGTPLFHLLPALGVSSFMQPLWELFWHTGDAPLLTVALIVNEQYYIQLRVVEHPFFRARVLSSWPFIVEQWLGFNDVLIPFEQNGRVNLAGTTVRDFIDVHHRIHIGKTLYSLLLFDARLFRGAVRFARRVPHSGSRADFWPQRFTADRGGHRLYSPTLESVWPDLIHSFSDQRDWFTDHTIIRALETLPLPASGDMTGRYERHLAMMKAAAQAAE
>NZ_AP022557.1|WP_033843948.1|898852_899170_+|hypothetical-protein
MVRFWGKRRWMSKRVYEAVVFQTPRCGEPKGYRQVCRLTVTASSHDEALSIIYRTFNVADLMPKHCQARFMGTGDIVLIDEGRKGQTYYRLCPDGWKRVERQAVC

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Crispr_ID: NZ_AP022557_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_8

959192-959283

Orphan

Consensus_repeat	Method
TCACCACAATATGGACTTGACAGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_8

>merge|NZ_AP022557|8|959192-959283|CRISPRCasFinder
TCACCACAATATGGACTTGACAGACCCCGCCTCCCTTTTGTATTTCGTTGTGATTCGGTCAAGTTCATCACCATAATATGGACTTGACAGAC

>NZ_AP022557|8|8|959192-959283|CRISPRCasFinder
TCACCACAATATGGACTTGACAGAC	CCCGCCTCCCTTTTGTATTTCGTTGTGATTCGGTCAAGTTCA
TCACCATAATATGGACTTGACAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843902.1\|954378_955026_-\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225167
NZ_AP022557.1\|WP_172418550.1\|959493_960378_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_AP022557.1\|WP_033843897.1\|957052_957442_+\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|377602
NZ_AP022557.1\|WP_033843884.1\|964861_965626_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_156102720.1\|949644_949815_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843899.1\|955030_956035_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NZ_AP022557.1\|WP_061912097.1\|967541_968132_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379409
NZ_AP022557.1\|WP_061912098.1\|962344_963259_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_AP022557.1\|WP_033843903.1\|952475_954275_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP022557.1\|WP_033843905.1\|950755_952492_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP022557.1\|WP_031409645.1\|966420_967170_+\|oxygen-insensitive-NADPH-nitroreductase	unknown	unknown	gnl\|CDD\|380322
NZ_AP022557.1\|WP_033022624.1\|961232_961538_+\|transporter-suffix-domain-containing-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843896.1\|957667_959026_+\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|223252
NZ_AP022557.1\|WP_033844920.1\|956230_956794_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239267
NZ_AP022557.1\|WP_051962697.1\|949208_949652_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_AP022557.1\|WP_033843886.1\|964376_964847_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843906.1\|949814_950261_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_AP022557.1\|WP_033843890.1\|961553_962345_+\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|239947
NZ_AP022557.1\|WP_061912096.1\|968218_968782_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843887.1\|963251_964232_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224196

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033843902.1\|954378_955026_-\|MOSC-domain-containing-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	1.3842e-74
NZ_AP022557.1\|WP_172418550.1\|959493_960378_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.68357e-29
NZ_AP022557.1\|WP_033843897.1\|957052_957442_+\|gamma-glutamylcyclotransferase	gnl\|CDD\|377602	pfam06094, GGACT, Gamma-glutamyl cyclotransferase, AIG2-like. GGACT, gamma-glutamylamine cyclotransferase, is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline.	6.72333e-25
NZ_AP022557.1\|WP_033843899.1\|955030_956035_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	2.04086e-172
NZ_AP022557.1\|WP_061912097.1\|967541_968132_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|379409	pfam13977, TetR_C_6, BetI-type transcriptional repressor, C-terminal. This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C-terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	1.08677e-19
NZ_AP022557.1\|WP_061912098.1\|962344_963259_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.24487e-101
NZ_AP022557.1\|WP_033843903.1\|952475_954275_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_AP022557.1\|WP_033843905.1\|950755_952492_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.6592e-156
NZ_AP022557.1\|WP_031409645.1\|966420_967170_+\|oxygen-insensitive-NADPH-nitroreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	4.87132e-113
NZ_AP022557.1\|WP_033843896.1\|957667_959026_+\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	0
NZ_AP022557.1\|WP_033844920.1\|956230_956794_+\|thioredoxin-family-protein	gnl\|CDD\|239267	cd02969, PRX_like1, Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic cysteine found in PRXs, which aligns to the second cysteine in the CXXC motif of TRX. In addition, these proteins do not contain the other two conserved residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF.	5.13554e-100
NZ_AP022557.1\|WP_051962697.1\|949208_949652_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.31392e-12
NZ_AP022557.1\|WP_033843906.1\|949814_950261_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.99508e-13
NZ_AP022557.1\|WP_033843890.1\|961553_962345_+\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|239947	cd04506, SGNH_hydrolase_YpmR_like, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. This subfamily contains sequences similar to Bacillus YpmR.	8.8057e-89
NZ_AP022557.1\|WP_033843887.1\|963251_964232_+\|ABC-transporter-permease	gnl\|CDD\|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	1.19613e-20

>NZ_AP022557.1|WP_033843896.1|957667_959026_+|type-I-glutamate--ammonia-ligase
MSNLFVSSTQTGLLEQIKETIQQKNVELLHLQFVDIEGILKHVTVTAEQLDDVVGGKIMFDGSSIKGFSPINRSDLYLLPDLNTFAVLPWTVEEGYAEARFLCSVTNPDGTLFEGDPRNVLKKTVERAAEKGYTISVGPELEFFLFKADEHGNPTLELHDNGGYFEPSPKDLGERVRLEIYRALKAMGFTIEASHHEVAEGQHEINFKYADALGAADNATTYKWVVKTIAGKFGLHATFMPKPVFGINGSGMHVNISLFKDGENAFFDPNDANQLSATAYQFIAGLLKNVKHFAAVTNPLVNSYKRLVPGYEAPCYIAWSASNRSALIRIPAKRGMATRVELRCPDPSANPYLAYAIIAAAGLDGVEKGLTPPAAIDEDIFHMSEERRAVLGIDNLPENLGAAIAAFEDGEIGRATLGEHVFHEYVAMKKDEWNSYRTAVHAWEIERYQGKF
>NZ_AP022557.1|WP_033843897.1|957052_957442_+|gamma-glutamylcyclotransferase
MAERRYRVFVYGTLLTGEDNHPIAAPYVRDVRPGKVKGRLYNVGLYPALVLGEEGEVEGEWLTVTEEGLKAMDELEDYGEGRDDNEYERVWVRDVCQPLEGYVYVYRPEKAVGLPLIPSGSWRHRKENM
>NZ_AP022557.1|WP_033844920.1|956230_956794_+|thioredoxin-family-protein
MPAVESNMFPLGKQAPPFALTNVVDGRLVRLDDVKSDVATVIMFICNHCPFVKHVQHELVRLANDYMPKGVSFVAINSNDVEQYPDDSPENMKKVAEELGYPFPYLYDETQEVARAYDAACTPDFYIFDRELKCVYRGQLDDSRPSNGIPVTGESIRAALDALLAGRPVPEHQKPSIGCSIKWKPSS
>NZ_AP022557.1|WP_033843899.1|955030_956035_-|LLM-class-flavin-dependent-oxidoreductase
MPLELSVLDQSPIAKGTTAEEALANTVRLAQFVEELGYKRFWVSEHHDTNSLAGSSPEVLLGYIGAKTSRIRIGSGGVMLPHYSAYKVAENFHVLAGLAPGRVDLGVGRAPGGMPRATMALHDGKQRPIDRYPEQIDELLGYLHDALPPVHPLYGVKATPIVQSPPDVWLLGSSSETAKLAAEKGLPYVFAQFINGDGGEAAMRSYRERFAPSPYLDKPRSMVAVFAVCAESEEKAEWIAGSLDLTLLMIEQGMAVNGIPAPEQAAAYRYSPYERQRVADNRRRMIVGSPARVKDELYRLSEAYETDEIMLVTITYDFHDKLTSFRLIAEAIWG
>NZ_AP022557.1|WP_033843902.1|954378_955026_-|MOSC-domain-containing-protein
MRIVSINVGTPKTLDINGQPLVSGIDKTPVAGPVAVGKRHLAGDGQADLVHHGGEDKAICAYPSEHFAYWERHYGRPFAAGAFGENWTLAGLTEDEACLGDIYAAGTALVQVSQPRQPCSKLALFHQLPGLPKAVIQTGKSGFYLRVLNEGVVEPGAALLLVERGQGALSIAYINRIYYHERDNVTAMEQLAYHPALSASWREAFLHRLAAQTEP
>NZ_AP022557.1|WP_033843903.1|952475_954275_+|ABC-transporter-ATP-binding-protein
MSLRHSPHGARQPGRQRAKSSMGTLRRLWTFIAPQKRKLLAALGMVVASTALALAGPYVIGSAIDVYIVERKTDGFLTTLLFLLAIYAALGAATFLQNYWMIAVGQRTVHAIRARLFRHFHELPISFFDRRQQGELMSRITNDIDNMSQTFNSTVIQVVSSTLTLAGAIAVMVFKSLVLTAVTLVVVPLMYAGMRWITRRTQVRFREQQRALGEMNGLIEEALSGQKVVKLFSQEERMTAEVVRKNIELKQAGFWAQTYSGFIPKLMNFLNNLSFALIAGVGGWLAVKGMISVGTIVVFVEYARQFTRPLNDLANQWNTLLSALAGAERVLEIFDLPKEEEDEGEAEEIDRLHGRIEFRDVVFSYDKQRPALRGVNFSVSPGETVALIGPTGAGKTTVLQLLARFYDPDAGAVVIDGRDSRTIKRASLRRHMAFVLQDTFLFAGTIRDNIRYGRLEATDEEVEEAARKANAHSFITKLPNGYDTVLTADGGGISQGQRQLLAIARAMIADPAVLILDEATSNIDTVTEVRIQEALARLMAGRTCFVIAHRLNTVQNADRILVLNEGKVVEQGTHEELLEAKGFYFELYRRYWERGRQRA
>NZ_AP022557.1|WP_033843905.1|950755_952492_+|ABC-transporter-ATP-binding-protein
MRQVLVYLRPHRKWMAVAWLLMLTELVIELWQPLLMGKIIDEGVMNRDLTAIATWGSVMLGASFLAFAAGIANSFAAAYVGQEYGFALRTTLFAKIQSLSLARIEQLSTASLITRMTNDVTQVQNMLFMSLRIALRAPLLVIFGVGMAFVVQARLAFVLAVAVPLSAAFLLWVMKKAGASFSAVQRALDRVNGVMRENLAGMRLIKAWVRNEYEQGRFLGANDALMERTISVFRLVETITPVLLFVMNAAIVAVLFFGRHDVEAGTASAGQVVAVVNYATRATAALSMFTFITMAWSRARASAARLAELLDAPSEPDGGHTVEPPAAKRGEIRFEHVSFRYPGSGRDALSGVSFVVRPQETVAILGATGAGKSTLLQLIPRLYEPSAGRVLIDGVDVREWPAKQLREAVRFVPQEVLLFSGTVADNLRFGKTEATMEELVEAASAAQIHETIATFPDGYETVVGQKGVNLSGGQKQRLAIARALVGRPQILLLDDSTSALDAATEAKLLAALRRYACTMVIVTQKVSTAMMADTILLLEDGRLTAQGSHEQLLAASELYRRIVATQEGKKGQSHVTTA
>NZ_AP022557.1|WP_033843906.1|949814_950261_+|STAS-domain-containing-protein
MEQHRFLFELERIAKPAYDCVVLTGRLAYHTQLAAEQKLAAAAAAVEHPLVIVDTSGLQFLDSTGLALLVRFFKRVVSAGRAMAIVVRENAMIEKILLIAKLNRLLPIAADEQQVLALAPLSSPGPIEQAVLLEAWQQRRAEGGDGSG
>NZ_AP022557.1|WP_156102720.1|949644_949815_+|hypothetical-protein
MDENTRRATGLFFHRKGRPNVLGASLRRLMGKEKRVTDVWWADGADGRRLANDRGI
>NZ_AP022557.1|WP_051962697.1|949208_949652_+|ATP-binding-protein
MWLSWVVSCQAGEEAVEWFDFIAKQAARLLAVRDADLFVLAVHEAVVNAVKEAKRAGDGSRTISLSFFVTADDVTVMVEDEGDGISLETIERLAGMTLADVLLAESGRGLLLIREAMDAMAWMERPDGRRVLVMAMKRKAGWEGGDG
>NZ_AP022557.1|WP_172418550.1|959493_960378_+|sulfite-exporter-TauE/SafE-family-protein
MKKLIVFLFVGLIAQLIDGSLGMAYGVTSTTLLLTFGIAPAVASASVHLAEVATTAASGISHWKFGNVDRAMVVKLIIPGSVGAFVGACFLSNLPGDLIKPYVSLFLLMLGFYIIYRFLVLNGRAPSASGKQWSNKQLVPLGLVAGFLDATGGGGWGPIATPVLLANRTMEARKVVGTVDTSEFAVALSATIGFAISLGWEQVNWYWVLTLMAGGIIAAPIAAWLVRKLPSHLLGVLVGGLIILTNVRTLLHAWEAPASVYPTVYSLIVIGWAAAVILAVRNGRKGVASKEMAS
>NZ_AP022557.1|WP_033022624.1|961232_961538_+|transporter-suffix-domain-containing-protein
MKRKPSARQRIGVGLIIASFVVWVVPPIAPFLPFSASVKAWAVTSAVVLAEMLFWAGAWLVGKEAAAKLRKYWNPKRWRMKRRPEQTNDAETDGERQRQSK
>NZ_AP022557.1|WP_033843890.1|961553_962345_+|SGNH/GDSL-hydrolase-family-protein
MRLGVVGLVIAAAAMSAALWLGGLVLAVQDQLAPPSKPPGQTQPSVHGAKKGDGDIDIVALGDSLTRGTGDESGKGYVGYMVDELRKQTEAPIRVTNLAVRGLRSDGLLRQLGQPEIQRQIAMADLIVMTIGGNDLFRGGEALRLNEKELNAAKRQYAANLDRIFAMLRRFNTDAVILAIGLYNPFSDFGDAKRTSAVVRDWNFVAAEVAARYPNVVAVPTFDLFALHVNDYLYSDHFHPNQEGYKRIGERVASLITLTEENR
>NZ_AP022557.1|WP_061912098.1|962344_963259_+|ABC-transporter-ATP-binding-protein
MMKPVTLAVHELRKTIRGKEIIRGVSFALHEGEVFGFLGPNGAGKTTTIRMLVGLIRPTSGTVMIGGYDLHRQFTEAIRQIGCIVENPEMYPYLTGWENLEHFARMMPGIGADRIMEVAKLVGLEQRIHDRVSAYSLGMRQRLGIAQALLGKPKVLILDEPTNGLDPAGIREMRAFIRFLAETEGLSVLVSSHLLSEIQLMCDRVAIMAKGRLLAVDTVERLLNEQARVVWKAAPLDRAQALLAEETEVLRADEEGIITPYEPAKLAAWNAKLVRAGVAVAHIEPRLPTLEDLFIELTGGETIE
>NZ_AP022557.1|WP_033843887.1|963251_964232_+|ABC-transporter-permease
MSKLVYNEMLKIVRKKRLWVIAAIVAVLVALFTYAQYRETEELRKRLGTTDWRTQLQQQIVDLQNRLQSPSMSEEWRKYLQIRLKQQQYYLEHNVNPSAPGAPTFMRTFIENAIDLFLPLLVMVVAADLVSSEASAGTIKLLLVRPVKRWKVLLSKYIALLLSVSFIMLTTAVLSYAISGLVFGYGGFHLPLLTGFVSQGEDLNTDNVHMIPQWKYILMELGLAAFVSTVVGTLTLMLSVLFRSTAAVMGVMLAALISGAILSNMVSSWQSAKYLFMVNLRLTDYLKGAAPPIEGMTLGFSMTVLAVWGLMALAVAFVVFARRDVY
>NZ_AP022557.1|WP_033843886.1|964376_964847_-|hypothetical-protein
MIVVATFENHLFVELVISALREKGVPPHHLFAVPLDGRPEPPQLLDTIHRADGLSFLDLAAIFGTCFMLLGSIYGYVLTWGPIIWGVIGAVVGISLGLLLKWGLNRNTARRQTNRRAEIVLLIRCDETQWPMIERLLWNHHALGLAGIDDEKRTRQ
>NZ_AP022557.1|WP_033843884.1|964861_965626_-|hypothetical-protein
MKFIPPARRKRAYLSQFTTTNLHLRHPLVVAFFSFSFPGFGNLMLHRYATAFILIVWELFINTKAHVNAGILYSLLGDFEKAKAVLDERWLMFYVAIYIYGIWDSYRGAVDMNKLYLLADREDAPIPPLRMGGWDINYLDKRKPWLALAWSVLAPGLGHLYVHKVIAGLFLFGFTIIVSYFARLPEAIIYTLTGRFDEAVRIVNMQWALYLPSIYSFVFYDAYVSAVEYNKLFEKELSNYLRRRCQPKPFRWPI
>NZ_AP022557.1|WP_031409645.1|966420_967170_+|oxygen-insensitive-NADPH-nitroreductase
MNPVIETILQHRSIRRFEDRPLTDEQIRTIVECAQAASTSSYIQAYSIIGVKDPEKKRKLAELSGNQSYVEHNGHFFVFCADFHRHELIGELEGKDVIPSLESTEKFMVALIDTALAAQNAAIAAESMGLGICYIGGLRNNLPDVCALLNVPKRVIPLFGLAVGYPAQTPDRKPRLPFAHVYHEDEYNQDRAPFLEQLQRYNDTVSAYYEQRTNGRRRDTWTGQMADMLSRSVRMYMKEFVEGKGFNLR
>NZ_AP022557.1|WP_061912097.1|967541_968132_-|TetR-family-transcriptional-regulator
MPKIVDHEKQRKRIAEATWTVIMRDGIEKATVRNIAKEAGMSAGALRYYFTSQSELLAFSMRLVSERVRERVEAIPPSIPPLEGVKRCLLELLPLTDETKKEMEVWLVFTQRALWDPALQPLSEQIYHQLRTAMKRMLELLRDLGLLRSDVSIELETERLYALVDGLAMHGIMQSGKLSPSKIEEIIEYHLRSICR
>NZ_AP022557.1|WP_061912096.1|968218_968782_+|hypothetical-protein
MIGWLIIACEVLFWVFVISGLFTRYVLKWKMTSVCLFLCTILADLILLVVSVVDLAHGQTAKLSHSLAAVYIAVSVVYGRRMIQWADHQFVHLFLKMPRPKKSLLFGKEHAKHERLGWYRHLRAWAIGQAILLAMVWFVGDMSKAKELLMMAGRWTLVLVVDFVWSFSYTVWPRKEPKEILAKPRNW

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Crispr_ID: NZ_AP022557_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_9

1045661-1045761

Orphan

Consensus_repeat	Method
CTGCAAGGGTTTTCTATTTAAGAAATAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_9

>merge|NZ_AP022557|9|1045661-1045761|CRISPRCasFinder
CTGCAAGGGTTTTCTATTTAAGAAATAGTCCGCACCCTCGCCTTCCCGTCGCGTTGTCGCGTTCTAAACTTTCTGCAAGGGTTTTCTATTTGAGAAATAGT

>NZ_AP022557|9|9|1045661-1045761|CRISPRCasFinder
CTGCAAGGGTTTTCTATTTAAGAAATAGT	CCGCACCCTCGCCTTCCCGTCGCGTTGTCGCGTTCTAAACTTT
CTGCAAGGGTTTTCTATTTGAGAAATAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_153017108.1\|1052973_1053261_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_AP022557.1\|WP_061912130.1\|1055124_1056084_-\|DUF979-domain-containing-protein	unknown	unknown	gnl\|CDD\|377620
NZ_AP022557.1\|WP_061912255.1\|1041632_1043309_-\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|223733
NZ_AP022557.1\|WP_061912261.1\|1032776_1034192_-\|PTS-system-trehalose-specific-EIIBC-component	unknown	unknown	gnl\|CDD\|273916
NZ_AP022557.1\|WP_031409465.1\|1043360_1043660_-\|ATP-synthase-subunit-B	unknown	unknown	gnl\|CDD\|226447
NZ_AP022557.1\|WP_061912131.1\|1054444_1055092_-\|pyroglutamyl-peptidase-I	unknown	unknown	gnl\|CDD\|237299
NZ_AP022557.1\|WP_061912129.1\|1056084_1056771_-\|DUF969-domain-containing-protein	unknown	unknown	gnl\|CDD\|368767
NZ_AP022557.1\|WP_061912258.1\|1035838_1036183_-\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NZ_AP022557.1\|WP_033019880.1\|1040775_1041195_-\|CoA-binding-protein	unknown	unknown	gnl\|CDD\|224745
NZ_AP022557.1\|WP_061912262.1\|1030973_1032665_-\|alpha,alpha-phosphotrehalase	unknown	unknown	gnl\|CDD\|274115
NZ_AP022557.1\|WP_061912133.1\|1050623_1052876_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_AP022557.1\|WP_061912134.1\|1050360_1050627_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912260.1\|1034589_1035315_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133392
NZ_AP022557.1\|WP_033843871.1\|1046696_1048367_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912254.1\|1045878_1046511_+\|DUF2238-domain-containing-protein	unknown	unknown	gnl\|CDD\|378345
NZ_AP022557.1\|WP_061912256.1\|1038677_1040615_-\|DNA-topoisomerase-IV-subunit-B	unknown	unknown	gnl\|CDD\|130130
NZ_AP022557.1\|WP_061912257.1\|1036185_1038621_-\|DNA-topoisomerase-IV-subunit-A	unknown	unknown	gnl\|CDD\|235503
NZ_AP022557.1\|WP_061912263.1\|1030237_1030951_-\|trehalose-operon-repressor	unknown	unknown	gnl\|CDD\|274116
NZ_AP022557.1\|WP_172418554.1\|1057315_1057933_+\|sulfite-oxidase-like-oxidoreductase	unknown	unknown	gnl\|CDD\|239027
NZ_AP022557.1\|WP_051962818.1\|1053395_1053977_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_153017108.1\|1052973_1053261_-\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	4.00664e-05
NZ_AP022557.1\|WP_061912130.1\|1055124_1056084_-\|DUF979-domain-containing-protein	gnl\|CDD\|377620	pfam06166, DUF979, Protein of unknown function (DUF979). This family consists of several putative bacterial membrane proteins. The function of this family is unclear.	1.79596e-141
NZ_AP022557.1\|WP_061912255.1\|1041632_1043309_-\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	1.33702e-165
NZ_AP022557.1\|WP_061912261.1\|1032776_1034192_-\|PTS-system-trehalose-specific-EIIBC-component	gnl\|CDD\|273916	TIGR01992, phosphotransferase_system_trehalose_permease, PTS system, trehalose-specific IIBC component. This model represents the fused enzyme II B and C components of the trehalose-specific PTS sugar transporter system. Trehalose is converted to trehalose-6-phosphate in the process of translocation into the cell. These transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci and Streptococci which contain their own A domain as a C-terminal fusion. This family is closely related to the sucrose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively). In E. coli, B. subtilis and P. fluorescens the presence of this gene is associated with the presence of trehalase which degrades T6P to glucose and glucose-6-P. Trehalose may also be transported (in Salmonella) via the mannose PTS or galactose permease systems, or (in Sinorhizobium, Thermococcus and Sulfolobus, for instance) by ABC transporters.	0
NZ_AP022557.1\|WP_031409465.1\|1043360_1043660_-\|ATP-synthase-subunit-B	gnl\|CDD\|226447	COG3937, COG3937, Uncharacterized conserved protein [Function unknown].	4.51023e-10
NZ_AP022557.1\|WP_061912131.1\|1054444_1055092_-\|pyroglutamyl-peptidase-I	gnl\|CDD\|237299	PRK13197, PRK13197, pyrrolidone-carboxylate peptidase; Provisional.	5.69619e-138
NZ_AP022557.1\|WP_061912129.1\|1056084_1056771_-\|DUF969-domain-containing-protein	gnl\|CDD\|368767	pfam06149, DUF969, Protein of unknown function (DUF969). Family of uncharacterized bacterial membrane proteins.	8.50519e-115
NZ_AP022557.1\|WP_061912258.1\|1035838_1036183_-\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	9.94698e-11
NZ_AP022557.1\|WP_033019880.1\|1040775_1041195_-\|CoA-binding-protein	gnl\|CDD\|224745	COG1832, COG1832, Predicted CoA-binding protein [General function prediction only].	8.07401e-61
NZ_AP022557.1\|WP_061912262.1\|1030973_1032665_-\|alpha,alpha-phosphotrehalase	gnl\|CDD\|274115	TIGR02403, Trehalose-6-phosphate_hydrolase, alpha,alpha-phosphotrehalase. Trehalose is a glucose disaccharide that serves in many biological systems as a compatible solute for protection against hyperosmotic and thermal stress. This family describes trehalose-6-phosphate hydrolase, product of the treC (or treA) gene, which is often found together with a trehalose uptake transporter and a trehalose operon repressor.	0
NZ_AP022557.1\|WP_061912133.1\|1050623_1052876_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.49887e-88
NZ_AP022557.1\|WP_061912260.1\|1034589_1035315_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133392	cd04764, HTH_MlrA-like_sg1, Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators. Putative helix-turn-helix (HTH) MlrA-like transcription regulators (subgroup 1). The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins.	3.25396e-20
NZ_AP022557.1\|WP_061912254.1\|1045878_1046511_+\|DUF2238-domain-containing-protein	gnl\|CDD\|378345	pfam09997, DUF2238, Predicted membrane protein (DUF2238). This domain, found in various hypothetical bacterial proteins, has no known function.	1.69292e-62
NZ_AP022557.1\|WP_061912256.1\|1038677_1040615_-\|DNA-topoisomerase-IV-subunit-B	gnl\|CDD\|130130	TIGR01058, DNA_topoisomerase_4_subunit_B, DNA topoisomerase IV, B subunit, Gram-positive. Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation step of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_AP022557.1\|WP_061912257.1\|1036185_1038621_-\|DNA-topoisomerase-IV-subunit-A	gnl\|CDD\|235503	PRK05561, PRK05561, DNA topoisomerase 4 subunit A.	0
NZ_AP022557.1\|WP_061912263.1\|1030237_1030951_-\|trehalose-operon-repressor	gnl\|CDD\|274116	TIGR02404, Trehalose_operon_transcriptional_repressor, trehalose operon repressor, B. subtilis-type. This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions].	3.38515e-107
NZ_AP022557.1\|WP_172418554.1\|1057315_1057933_+\|sulfite-oxidase-like-oxidoreductase	gnl\|CDD\|239027	cd02109, arch_bact_SO_family_Moco, bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate. The specific function of this subgroup is unknown.	3.02515e-86
NZ_AP022557.1\|WP_051962818.1\|1053395_1053977_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.91853e-21

>NZ_AP022557.1|WP_031409465.1|1043360_1043660_-|ATP-synthase-subunit-B
MSILKKGLAFGLGLAIASKEQAEKIIDELVKKGELSLDESKEVIDQWKQQTEARKTEVQRLVREQIKQVIDKLDLATKEDVRQLEERIRRLEEKEQSGQ
>NZ_AP022557.1|WP_061912255.1|1041632_1043309_-|AarF/ABC1/UbiB-kinase-family-protein
MIGKRMRHIGRYHEIAVALLRHGFGMIVDELGFSSFLSLPPRWRAEQGKKEGKTVAERLRLVLEELGPTFIKLGQIASTRPDLLPSPIIRELEKLQDQVPPFPFSEVRRIVETELGDSLEKLFRSFAEMPLAAASLGQVHRAVLPSGQAVVVKVQRPRIAAQMETDLDILQDLAVLAERRLEWAASYRLSEIVDELTKSLRQELDYTVEARHAETFAHLFADDPSLYVPGVFWEYTTKRVLTMEYIDGVKLGEIERLKESGYSLQALAERLAASMLKQMFEHGFFHGDPHPGNVFVLPGGVLAFIDFGLMGRLRPNVKHHLSTLVIALMRQNTDGVLNAIYGLGLVPDEVDEGTLRDDIDELREKYYRVPLSDISLGEAVEDLLTVAFRHGICIPSDLTLLGKALLTVEGVVEMLDPQFRIIDVAEPFGRKLLKERLRPDRVVETAWKRIFDYGKWLLRLPDSVKGWTKMMRHGKLRLEITAPDLETLLRKLDQMANRLSFSIVLLSLSIVLAGLMIASSLGRPSTLLWNIPAVEIGLGAAAFLFGWLLYSIFRSGRF
>NZ_AP022557.1|WP_033019880.1|1040775_1041195_-|CoA-binding-protein
MSIVNPSREEIGAILRKAKRIAVVGLSNNPERESYMVAKAMKDAGYEIIPVNPMIDEWEGIPAVDRLTDIDGHVDIVDVFRRSEHLPELAREFVQIDADVFWAQLGVVNEEAYRFLKEKGYTVIMDRCIKVEHALTRRA
>NZ_AP022557.1|WP_061912256.1|1038677_1040615_-|DNA-topoisomerase-IV-subunit-B
MAKQSVYEYNEEAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGYGNYIFVQIHKDNSITVLDEGRGMPVGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIHRDGFIYQQRFENGGKPVTTLEKIGTTNKTGTIIQFKPDPTIFSTTVFDYETLSERLRESAFLLKGLKIELVDERTGMREVFHYENGIEAFVAYLNEEKDVLHPVVYFAGEQNGIEVEFAFQFHDGYSEQVLSFVNNVRTKDGGTHEAGAKTAMTRVFNEYARRVGLLKEKDKNLEGTDIREGLSAIVSVRIPEQLLQFEGQTKGKLGTSEARSAVDAVVSEQLTYFLQENPDISAMLVKKAIRAYQAREAARKAREEARSGKKRKGKEAVLSGKLTPAQGRNPLKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLGDILKNEEINTIIHAIGGGVGADFSLEDVNYDKVIIMTDADTDGAHIQVLLLTFFYRYMRPLIEAGKVYIALPPLYKISKKSGKKETVEYAWTDEQLREITKKMGRGYTIQRYKGLGEMNADQLWETTMNPETRTLIRVRIEDAARAERRVTTLMGDKVEPRRKWIETHVAFGLEEEPGWIG
>NZ_AP022557.1|WP_061912257.1|1036185_1038621_-|DNA-topoisomerase-IV-subunit-A
MAERLLELPLEDVLGDRFGRYSKYIIQDRALPDVRDGLKPVQRRILYAMYIDGNTADKPFRKAAKTVGNVIGNFHPHGDSSVYEAMVRMSQEWKLRNVLIEMHGNNGSIDGDPPAAMRYTEARLSAMAAELLCDIDKETVPFVPNFDDTVKEPTVLPAMFPNLLVNGSTGISAGYATDIPPHALGEVIDAVLMRIDRPDCTVDELMTVLPGPDFPTGGIIQGKDGIRKAYETGRGKIIIRAKAAIEQARGGKQQIVITELPYEVNKAYLVKKIDELRLDKKLDGIADVRDETDRNGLSIVIELKKDADAEAILNYLYKNTDLQVPYNFNMVAIHERRPKLMSLPELLDAYIAHRKEVVTNRSHFELKKANERKHIVDGLIRALSILDEVIATIRAASDKRDAKDRLMAHYGFTEAQAEAIVTLQLYRLTNTDITALRQEAEELERAIAELTAILADEKKLLSVIKKELKAMKKRYADERRTVIEEEIEELKVNVEALIPAEDVIVTVTKEGYVKRTSYRSYSASNGQDIGMKETDRLLGQLEMNTTDVLLLFTRRGYYLYCPVHTLPDIRWKDVGQHISHLIPLERDDELVAAVPVSSFETADQLVFVTKQGLVKRTELAQYQVQRYHRPLVAVNVKEEDEVVAVYRTDGRGRLWLATHGGYALLFPEEEISFVGVRAAGVKGIQLKDGDVVAAACPFPPDGSGCFVVVTQRGAVKKMALAEFEPSSRAKRGISVIREVKSNPHRVVGAVVARDEERIGLRTEKGVVEMVEVASLRLSDRYGTGSFVIDIDEAGAVVDVWKEPPARISEGG
>NZ_AP022557.1|WP_061912258.1|1035838_1036183_-|PilZ-domain-containing-protein
MRFRRQEPFRYQFGQPLPAELTAADGRYEVLVHDISPHGLKVEADRPLPFSGGGSWVDVSLVLGGAALRVRGQLVWEKPFARIHYYGIRLDVTKQEEEGLIEAIKRHVAESRRR
>NZ_AP022557.1|WP_061912260.1|1034589_1035315_+|MerR-family-transcriptional-regulator
MKTYTLREAAKKIGVTARDLKQWEKQFAGSITIPRAPGGARLYNDELIERFRHIRAWLEDGRRPAEVADMINQLDAQQAEPAGERTAPTDTTVMEGEIIDPPRLLHQGMPYIAEQLAARLKDDLVRALKQETNRTIEQAMGEVKDRLDSLADQTAAAAETVRCSLRDYEDAWQQKTEQLHEHLETVVAICREEKARQEEERKRLEQRILEREKAFRELVLSFRQTAASSAATRAHKWWKFW
>NZ_AP022557.1|WP_061912261.1|1032776_1034192_-|PTS-system-trehalose-specific-EIIBC-component
MGAYQQAAAQIVEAVGGKDNIVAATHCVTRLRFALKEEGNVDKEALERIDVVKGAFSANGQFQVVIGQGLVDKVYDDLVELTGIGRATKQEIKDAAEAKLNPLQRAIKTLADIFIPILPAIVTAGLLMGINNVLTGPGIFYEGKSFVEVHKEWADLANMINLIANTAFVFLPGLIGWSAVTKFGGSPLLGIVLGLMLVHPDLLNAWGWGAAKEKGEIPVWNLFGFEVQKVGYQGQVLPVLVASYVLAKLELFLRKRIPDAFQLLLVAPLALLITGFLAFIAIGPITFAIGNAITHLFVTIFDTVPALGGLLYGALYAPLVVTGMHHTFLPVDLQLIANTGGTFLWPILVMSNIAQGSAALAMMFVAKEEKLRGLSFTSAVSAYLGITEPAMFGVNLRFRFPFIAAMTGAAIAGMFITLNQVIAPSIGVGGLPGFLSIVPQKWTPFFIGMAIAIAVPFVLTFVFGKVRKIAR
>NZ_AP022557.1|WP_061912262.1|1030973_1032665_-|alpha,alpha-phosphotrehalase
MSTTPWWKKAVVYQIYPKSFRDTNGDGIGDLPGVIEKLDYLKELGIDVIWLTPIYASPQRDNGYDISDYFRIHPAYGTMDDFDRLLHEVHARGMKLVMDMVVNHTSTDHEWFQQARASKTNPYRSFYIWRDPKPDGGPPTNWQSKFGGSAWEYDEQTGQYYLHLFDVTQADLNWENEELRRRLYDMMHFWLKKGVDGFRLDVINLLSKDQRFPDDDGSVPPGDGRRFYTDGPRIHEFLQEMNREVFSKYDIMTVGEMSSTTINHCIRYTNPENHELNMTFNFHHLKVDYPNGEKWTVAPFDFLALKRILSEWQVRMHEGGGWNALFWCNHDQPRIVSRYGDDRTYWKESAKMLATTIHLMQGTPYIYQGEEIGMTDPKFTDIRDYRDVESLNMYRILRAQGKSEQEVIDILQRKSRDNSRTPMQWDDSPHAGFTSGTPWIRVADNYRRINVKQALADRDSIFYHYKRLIELRKQYDIITTGRYELLLADDPHLFAYMRHGDREKLLVVNNFYPVETTFVLPEEAGANDCTAELLLANYSDAPTDFRRMRLRPYESVVYLLRRP
>NZ_AP022557.1|WP_061912263.1|1030237_1030951_-|trehalose-operon-repressor
MHENKYLTIYHDLISRIRRGEWKAYDKLPSEHELAARFETSRETIRKALQLLSEHGYIQKMKGKGSIVLDVGKYDFPVSGLVSFKELAQTMKQPVRTIVHELAVIKPDGELKQQLRASSKDEVWKVVRVREIGGERIILDKDFFLKKHVPLLTEEICEDSIYEYLETTLHLPISFAKKEMSVDAATEEDRRYLDLNGDDRVVVVKNYVYLSDATLFQYTESRHRLDKFRFVDFARRK
>NZ_AP022557.1|WP_061912254.1|1045878_1046511_+|DUF2238-domain-containing-protein
MEQARQTRVHRWLLLIVAAVFVWSAIRPASYAVWALEVAPALIGLAMVIALYRRFPLTTMSYVIIAMLAILMLIGGHYIYSKVPFFNWIKEAFHFERNHYDRFGHFLKGTFAIVLREIVLRKTLLPRGAWLFTIVTSMSLAIAALYEIIEWLVSMISKGGKASKDFLGTQGDIWDTQWDMLCTLSGTLVALWLLAKWHDRQLVRLDQSHS
>NZ_AP022557.1|WP_033843871.1|1046696_1048367_-|hypothetical-protein
MAAQSERRWILFALGVIALYVSPLFILGENAHIRVHDNLDSNIAWYKVLAESGQITGPLDANIPQIANGELSRNALGSELTGIVWLHALFPTMTAYALSQTITRVVAFLGMYLLLKTHFLPERRWMAVRIGVALAFALTLFWPSGMLSTLGMPLALWAFLNIRKGERSWKNVAVLTLLPFYSSFVLGFFFFLVAMGVLWLLDVLRGKGWNIRFFLSIAYMTLLYLLVEYRLVYSFLWEDEPTSRDEYFHARLTFWHCVRLTWKNFLLGHHHVMTEHTLFILPAWFIALFLVFANQRWKEERVFLFLFGLNFALSAWYAFWFYKGWLPLTERFHFLDTFNFARFHFLRPLIIYVQFALALKIIWQSSEKGKTWAKRLLAAQIILVFLLNEELVSRYEPTVKQFYAEEQFQQIKQYIGLPVSEYRVVSIGLHPAIAQYNGFYTLDTYNNFYPLSYKYEFRQIIERELAKSKTIRTYFDEWGGRCYVFTAELGKRYMFTKHAKQRLKNLQLNTEQLKNMGGRYIFSAVPIDNAAENGLGLERVFTSDESAWTIYLYKVQ
>NZ_AP022557.1|WP_061912134.1|1050360_1050627_-|hypothetical-protein
MIYAIGFPNFQGITSIETDLPVLNKGDVVVINVRNRFLFKTGSTPTSYSLKAILPTLSQKEALRQFLWNGGTIITPLIEPCKPVMTCE
>NZ_AP022557.1|WP_061912133.1|1050623_1052876_-|MMPL-family-transporter
MFYWLAKWVTSHPKKIIFFWILCLLSSISFALKLPNVLTAGGFNDPKSESMKAQKILEENFSNQYPQQLLIVIKSSRYTVDDPNYETAVKRIVSVVRQNSKIENIESYYDHKNDAFIGKDKHNTFLVLGLNMSEDEAANFVPVLSRQLKEKVTGLDDYQWWVTGGPALSYALNDATKKDLSFAEMIAFPVMIVILLLVFRTVASTVLPLLMSAFALVITMAIAYFFAKDYTMNILLQNAVSMIGLGVIVDYALFIISRYRQELEHHSTVEAVQRAIVSAGRSVFFSGATVAISLSSLFLPNIMIFNSIALGGVIVVTMAVLVAITLLPALLTLMGPRIHWGRIPLFKERKPSKYWEKIAVLLMKRPVIFLIPSFILLSFMAYPSYKLNMQVPVASASILPEQDSARKGFEVLAGDFGQGNVFPIQVVLKAKHGTVLSDDNLKAIDQITNDIQNFNNVDKVVSLTNWNMEWKLSNYQQAYKAYDKLPDFVKDQLNKLTNHDRGHTTTILLVSPKTDADSKASRELVRKIRNLLKGNSTKNFESYVGGQSAIGVDFDQRIFNNLPMIIVTVFVISFVVLIVSFRSILLPVKALVLNSLVTLASIGMLVAVFQQGNFRGAINSITPVVLFAVLFGLSMDYEVLIINRIRELKDEGIPTIESIVKGISETAGLVNGAAAIMIAVFGAFAMVKVEVVKELGFGLAVAILLDATVIRSVLVPALMRVLGEANWWLPFRFAVPIHNRKNVETEEGLS
>NZ_AP022557.1|WP_153017108.1|1052973_1053261_-|hypothetical-protein
MAQYQLAMQLNPEEIFLYMGLGQCQLKLNLIEDARKTFLRVLELPSICPEGSSPKVVLDIFITYLTYATKKEQETNHVLHTLVQRSEPSVKYMLW
>NZ_AP022557.1|WP_051962818.1|1053395_1053977_-|TetR/AcrR-family-transcriptional-regulator
MNQKRKKEEIIEVAAREFAEKGYDGANINEIAIMAGIGKGTIYLYFKTKKDLYLETIRAIVDRFNEMSEQIVSMDLNPFEKLKLVIETFFQLERESISYLKLWSRHQFQHNPVFPEEVSKIFKDLRQPLCEIIEEGVEKGEFSTPYPTVTGYFILSLIVMLMPNLQRPNSVPLVQEEERIPFILDTVRKLLQK
>NZ_AP022557.1|WP_061912131.1|1054444_1055092_-|pyroglutamyl-peptidase-I
MKTVLVTGFAPFGGETVNPSLEAIKPFAGWKTDTYTVETREIPTVFGKAIETLYAAMEDVVPDLVICVGQAGGRPDLSIERVALNVNDARIPDNEGNQPIDTPIVPNGPVGYWSTLPVKAMVHELRRHGIPASVSHTAGTFVCNHLFYGLMHYIAESQRPIRGGFIHIPYLPEQAARHPGQPSMALETVVKGLRIAIDVAFRQEEDIATSEGSIC
>NZ_AP022557.1|WP_061912130.1|1055124_1056084_-|DUF979-domain-containing-protein
MWLSMEAVYIFLGIVVTLGSVWTFADRSNPKRLTSGLFYLLYGVTLLFGSVIPPFYTGVLVLIMVAIVGFGGLKLGKYEEASPEERQQHRQRLNNRLFIPALLIPILTVIGVTWLKNFKIGGAFLLDPNNFTLVSLGVATFMALLISMAMTRSTPFAAVKESRRLLETIGWAALLPQMLATLGTIFTTAGVGAAVSEWISTIIPTHSLFWIVVSYCVGMALFTMIMGNAFAAFPVMTAGIAVPLLIQQFGVDANHVAALGMFSGYCGTLMTPMAANFNIVPAALLDLRDQHHVIRVQVPTALILLAFNIVAMYVITLMD
>NZ_AP022557.1|WP_061912129.1|1056084_1056771_-|DUF969-domain-containing-protein
MVLIGVAIVIIGFIIRINPLLVVTLSGLATGLFAHQSLYEIIEQFGKAFTTNRYMAVFIATLPVIGLLERFGLREQAEHVVSNIKAATTGRILTAYLVIREAAAAAGLTSLGGHAQMVRPLVAPMAEGAAEAKYGTLPDRVRDDIRAHAAAVDNIGLFFGEDVFIAIGAILLMKGFFDQNGIPSDPLHMALWAIPTAVAALIVHSFRLHRLDRSLHKLLHRENGKGRA
>NZ_AP022557.1|WP_172418554.1|1057315_1057933_+|sulfite-oxidase-like-oxidoreductase
MSKQLPPGQFETEKWPILHEGDVYSFDEATWNFRLFGDVKEEVSLSYEEVMRLPKTISTVDMHCVTTWSKFDTTFEGIAFREFLRFVELHPDVKYVKIYGYLNGDRFGYSANLPLDALMGDDALFVYRWKDKHHDWQDISPKHGYPLRFIPPATFYLWKGAKWASGIRFMKKDEPGYWEERGYSMTANPFKEERFAESVSKFRFW

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Crispr_ID: NZ_AP022557_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_10

1358968-1359063

Orphan

Consensus_repeat	Method
GATTTTCATCCTTGGGTGGAGGGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_10

>merge|NZ_AP022557|10|1358968-1359063|CRISPRCasFinder
GATTTTCATCCTTGGGTGGAGGGCAAACCGTTGCCCATGGAACTTTCCGCGAAAATGCCGAACTGACGCGAGATTTTCATCCTTGGGTGGAGGACA

>NZ_AP022557|10|10|1358968-1359063|CRISPRCasFinder
GATTTTCATCCTTGGGTGGAGGGCA	AACCGTTGCCCATGGAACTTTCCGCGAAAATGCCGAACTGACGCGA
GATTTTCATCCTTGGGTGGAGGACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843606.1\|1351581_1352856_-\|imidazolonepropionase	unknown	unknown	gnl\|CDD\|236478
NZ_AP022557.1\|WP_033843602.1\|1357400_1357817_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_AP022557.1\|WP_033843596.1\|1367415_1368342_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NZ_AP022557.1\|WP_033843603.1\|1354695_1356183_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_AP022557.1\|WP_033020864.1\|1358216_1358699_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_AP022557.1\|WP_033843608.1\|1349456_1349852_+\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|184415
NZ_AP022557.1\|WP_033843609.1\|1348251_1348668_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_AP022557.1\|WP_033843599.1\|1363703_1365488_-\|oligopeptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173875
NZ_AP022557.1\|WP_033843595.1\|1368328_1369354_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_AP022557.1\|WP_033843605.1\|1352871_1354533_-\|urocanate-hydratase	unknown	unknown	gnl\|CDD\|235448
NZ_AP022557.1\|WP_033843597.1\|1366430_1367399_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_AP022557.1\|WP_172418571.1\|1372765_1374202_+\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|372646
NZ_AP022557.1\|WP_033843598.1\|1365500_1366409_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_AP022557.1\|WP_033843601.1\|1359254_1359638_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NZ_AP022557.1\|WP_051962678.1\|1356257_1357256_-\|formimidoylglutamase	unknown	unknown	gnl\|CDD\|212514
NZ_AP022557.1\|WP_033843607.1\|1350156_1351485_-\|YjiH-family-protein	unknown	unknown	gnl\|CDD\|225851
NZ_AP022557.1\|WP_033843610.1\|1346773_1347940_-\|SEC-C-domain-containing-protein	unknown	unknown	gnl\|CDD\|235521
NZ_AP022557.1\|WP_081130697.1\|1361288_1362662_+\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_AP022557.1\|WP_033021715.1\|1369656_1371147_-\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NZ_AP022557.1\|WP_033021716.1\|1371214_1372033_-\|aquaporin-family-protein	unknown	unknown	gnl\|CDD\|223653

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033843606.1\|1351581_1352856_-\|imidazolonepropionase	gnl\|CDD\|236478	PRK09356, PRK09356, imidazolonepropionase; Validated.	0
NZ_AP022557.1\|WP_033843602.1\|1357400_1357817_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	1.10434e-22
NZ_AP022557.1\|WP_033843596.1\|1367415_1368342_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	1.38071e-130
NZ_AP022557.1\|WP_033843603.1\|1354695_1356183_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	4.08229e-25
NZ_AP022557.1\|WP_033020864.1\|1358216_1358699_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	1.02305e-13
NZ_AP022557.1\|WP_033843608.1\|1349456_1349852_+\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|184415	PRK13953, mscL, large conductance mechanosensitive channel protein MscL.	1.07125e-74
NZ_AP022557.1\|WP_033843609.1\|1348251_1348668_+\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.000946826
NZ_AP022557.1\|WP_033843599.1\|1363703_1365488_-\|oligopeptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173875	cd08510, PBP2_Lactococcal_OppA_like, The substrate binding component of an ABC-type lactococcal OppA-like transport system contains. This family represents the substrate binding domain of an ATP-binding cassette (ABC)-type oligopeptide import system from Lactococcus lactis and other gram-positive bacteria, as well as its closet homologs from gram-negative bacteria. Oligopeptide-binding protein (OppA) from Lactococcus lactis can bind peptides of length from 4 to at least 35 residues without sequence preference. The oligopeptide import system OppABCDEF is consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and also is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_AP022557.1\|WP_033843595.1\|1368328_1369354_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.1785e-164
NZ_AP022557.1\|WP_033843605.1\|1352871_1354533_-\|urocanate-hydratase	gnl\|CDD\|235448	PRK05414, PRK05414, urocanate hydratase; Provisional.	0
NZ_AP022557.1\|WP_033843597.1\|1366430_1367399_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.81381e-112
NZ_AP022557.1\|WP_172418571.1\|1372765_1374202_+\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|372646	pfam13610, DDE_Tnp_IS240, DDE domain. This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.	4.33642e-22
NZ_AP022557.1\|WP_033843598.1\|1365500_1366409_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.79569e-78
NZ_AP022557.1\|WP_033843601.1\|1359254_1359638_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	3.81701e-23
NZ_AP022557.1\|WP_051962678.1\|1356257_1357256_-\|formimidoylglutamase	gnl\|CDD\|212514	cd09988, Formimidoylglutamase, Formimidoylglutamase or HutE. Formimidoylglutamase (N-formimidoyl-L-glutamate formimidoylhydrolase; formiminoglutamase; N-formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase; HutE; EC 3.5.3.8) is a metalloenzyme that catalyzes hydrolysis of N-formimidoyl-L-glutamate to L-glutamate and formamide. This enzyme is involved in histidine degradation, requiring Mn as a cofactor while glutathione may be required for maximal activity. In Pseudomonas PAO1, mutation studies show that histidine degradation proceeds via a 'four-step' pathway if the 'five-step' route is absent and vice versa; in the four-step pathway, formiminoglutaminase (HutE, EC 3.5.3.8) directly converts formiminoglutamate (FIGLU) to L-glutamate and formamide in a single step. Formiminoglutamase has traditionally also been referred to as HutG; however, formiminoglutamase is structurally and mechanistically unrelated to N-formyl-glutamate deformylase (also called HutG). Phylogenetic analysis has suggested that HutE was acquired by horizontal gene transfer from a Ralstonia-like ancestor.	2.15348e-108
NZ_AP022557.1\|WP_033843607.1\|1350156_1351485_-\|YjiH-family-protein	gnl\|CDD\|225851	COG3314, COG3314, Uncharacterized protein conserved in bacteria [Function unknown].	3.7369e-131
NZ_AP022557.1\|WP_033843610.1\|1346773_1347940_-\|SEC-C-domain-containing-protein	gnl\|CDD\|235521	PRK05590, PRK05590, hypothetical protein; Provisional.	2.00988e-14
NZ_AP022557.1\|WP_081130697.1\|1361288_1362662_+\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.25216e-16
NZ_AP022557.1\|WP_033021715.1\|1369656_1371147_-\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NZ_AP022557.1\|WP_033021716.1\|1371214_1372033_-\|aquaporin-family-protein	gnl\|CDD\|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	6.52811e-85

>NZ_AP022557.1|WP_033020864.1|1358216_1358699_-|PaaI-family-thioesterase
MEETIVHAIQDDYPEEFAWCYGCGRLNETGHHFRTGWQGDKTVTVYTPRPEHTAIPGFVYGGLIASLIDCHGTGSAALALHRKNGHEPGSGETPPRFVTASLHVDFLKPTPHGVPLVAIGTVTEIHPKKWQVDTEVFANGELCARGQVVAVVMPKTFVRS
>NZ_AP022557.1|WP_033843602.1|1357400_1357817_+|PaaI-family-thioesterase
MKSTVNLHDVIAGQSAPPPCDTTLGVRLTEARDGYAKGVWKVSESLLNGNGVIMGGFVGAATDIVMAYAVTTLLRDDQMHASINLHTTFHRPLEAGEAEIEALVEKPGRTVAYVTATVRQNGKEVASATSSVLIMEKR
>NZ_AP022557.1|WP_051962678.1|1356257_1357256_-|formimidoylglutamase
MYQQPEKSRWTGRVDSVSDERAFRLHQRIRLLDLSQPLAPMEQAAALIGFACDEGVRRNQGRQGAKEAPAAVKAALGRLPWHLPQGASIFDAGDVVCVDGQLEQSQAELGKAVARLLRSGAVPVVIGGGHETAYGHYLGVREALGTDARLGIINIDAHFDLRPYDNGPTSGTMFRQILDKDKQVGYCCLGIQKLGNTAALFADAQRYGCEYMLEEQLTAGPMEAAYEQIERFASTYDGVMLTICMDAISAAAAPGVSAPSPFGLAPSLVRALIRRIVSHPNTISVDLCEVNPLVDEGGKTVALAAAFCLEILLHLQCLQGGPPFKSGLSGGS
>NZ_AP022557.1|WP_033843603.1|1354695_1356183_-|AraC-family-transcriptional-regulator
MKLVIAERDDKEREAIRWLVSAYSLPIEQVYTAATVEEMMALLEREAPELLYVELDMIPYEQWGKAASCIRLFCQRVIAATAEATFARAKQAIDWQCVDLLVKPLEPAKLKQALRTAASFSAGDGRSRASVGVGGYDDDYRSLFVDERVDVSTHVWLVQAEQPAFSSEVVRFLTGYPFRRRARVLPLTHMAACLFPELPGDGKEEAWKMLRDWEEDHHEPLAVVIMPPDGRRSVRERYQAARRLLETTFFIGYRQVIAPAPDDGPWRHLDPFLTPEEQRQWIEMLERFDHEAVKRWLQREFSDWTSPFPSPEMVRTRLTSILAQIRRFMKTYRLDRGATEREYMRLFQEILYNPVLYRIVQELILFLHRLLDEARQAAEDARVDAIERGLRYMEAHFRDPSLSLEQAAAAAGRSPAYFSHLLSKKRGVTFRQWLTNRRLEEAKRLLRQTDLSIKEIAEQTGFRTAHYLTRVFKAELNQTPTAYRDEQRSYRSSPR
>NZ_AP022557.1|WP_033843605.1|1352871_1354533_-|urocanate-hydratase
MTMTDKRTVQALSGTTRRAKGWIQEAALRMLHNNLHPDVAERPDELIVYGGIGKAARNWECYEAIVDTLLRLENDETLLIQSGKPVAVFRTHPDAPRVLMANSNLVPAWATWDHFHELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAEVARQHFGGTLAGTITVTAGLGGMGGAQPLAVTMNGGVCLAVEVDPARIQRRLDTKYLDTMTDSLDAALAMAKRAKEEKTALSIGLVGNAAEVLPQLVDIGFVPDVLTDQTSAHDPLNGYIPAGLTLEEAAELRVRDPKQYVARAKQSIAEHVRAMLAMQHRGAVTFDYGNNIRQVAKDEGVEDAFSFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFSENERLCHWIRMAQKQIQFQGLPARICWLGYGERAKFGKLINDMVARGELKAPIVIGRDHLDSGSVASPNRETEAMKDGSDAIADWPILNALLNAVGGASWVSVHHGGGVGMGYSIHAGMVIVADGTKEAEKRLERVLTTDPGLGVVRHADAGYELAIRTAKEKGIDMPMLK
>NZ_AP022557.1|WP_033843606.1|1351581_1352856_-|imidazolonepropionase
MRPLFVRRARQLVTLAGSSAAPLVGEQMSNLSIIENGSVWIENGTITAVGPDDELVRRFADRLAEAEVIDARGKTVTPGLVDPHTHLVYAGSREHEWTMRLGGATYMEIMNAGGGIHATTKATREASEETLYEESKRRLDQFLLHGVTTVEAKSGYGLSLEHEIKQLNVAKRLDDTHPVDVVSTFLGAHAVPPEWKHDREEYIRLIIEEMIPEVSRQGLAEFNDVFCERGVFTPDEARRILEAGKAHGLTPKIHADEIEPYGGAELAAEVGAISADHLLRASDEGLRRMAERGVIGVLLPGTAFFLLTNAAHARRLLDAGVPVALATDCNPGSSPTVSLPLVMSLACLHMRMTPAEALAAATINAAHAIGRAHVIGSLELGKKADLVVFNVPNYVQIMYYYGVNHAETVIKDGKVVVAGGKVRV
>NZ_AP022557.1|WP_033843607.1|1350156_1351485_-|YjiH-family-protein
MKADPTMAPSTPAPTPASGAWKFFVFSAIGIFVFFVPVSIGGTSSILLDHIVTWIRTQFPGLVPYYALIVIALGAVYPFYSKTWNKDAVTAVFSILKVLGLIVAVMLVFRIGPAWLFQPDMGPFLYDKLVVSVGLLVPIGSVFLALLVGYGLLEFVGVWMQPIMRPIWKTPGRSAIDAVASFVGSYSIGLLITNKVFKEGKYTVKEAAIIATGFSTVSVTFMVVVAKTLGLMSIWNTYFWVTFLVTFAVTALTARMWPLSRMSDEYYDGKGDPEQKVTGNYMKQAWSEAMKAVAQSKGIGTNIWENLRDGFIMTMGILPSIMSVGLIGLLLAEYTPLFDWLGYLFYPFTLLLQIPEPLLAAKASAIEIAEMFLPALLVTEAPLVTKFIIAVVSVSAILFFSAVIPCIVSTEIPLSLPKLLVIWFERTVLTLILTAPLAYWLL
>NZ_AP022557.1|WP_033843608.1|1349456_1349852_+|large-conductance-mechanosensitive-channel-protein-MscL
MWNEFKKFAIRGNVIDLAVGVIIGGAFGKIVSSLVNDIIMPLVGLILGGIDFSSLSWKVGKAEIKYGAFIQTVVDFLIIAFSIFLFVKLINTLYERVKKQEEVKETAPTLTKEEELLTEIRDLLKQQREMM
>NZ_AP022557.1|WP_033843609.1|1348251_1348668_+|hypothetical-protein
MEEKTILAQILQALDLYATDMRKQFEALYEKFDSLQQQVQTLNEQTNMMNKRMEDMERHMEEMDKRIEEMDGRIEEMDGRFERQIAQLERTVNERFERLEAKLGHIRVELVETQETVDFHSVKIAQHDRKIRHLLHTR
>NZ_AP022557.1|WP_033843610.1|1346773_1347940_-|SEC-C-domain-containing-protein
MSFLETIEPYLFCEDPLLRQFAFYAIEEYPGVPAAWVERLIDEAVTTADEETRSMILRGVSKQPLTDRALEQLLTIKDAAKYVRWFFPFSVAQLETYGQQLLRHFPRSWQRAVRLVAEGAEDDVWDHYFSLLSRLEQEEMFNQNLFFAAKQVVRILVEREWLTKEDVSLTWMKNEQQPWFSYDGILAVYALSLLGATEYIPRLASLLEQQDDDVLLDQVVYALSTFQNGEVIEAVCPYAFQKETAFSAIHVLANIKSKQAVRVLRDVFSELRDDDMHAFCFEALCHQLDQEALPEVEEYLERVEKWGHSGLIDVEQTAYGYYTILGLDHPKLEKWKALAEQRYRHFQALLQNPPLPKNVPYRREEPKIGRNDPCPCGSGKKYKKCCGK
>NZ_AP022557.1|WP_033843601.1|1359254_1359638_-|VOC-family-protein
MAVKKFEHVGIQVKDIETSKAFYQNVVGLELLSEMIHTNGTMKLAFLGLDGQVIVELIEGYNPDLPTEGKVHHVAFTVEGIEQEKERLVSLGVPLIWEDITALPNGAKYLFFLGPDGEWIEFYEPER
>NZ_AP022557.1|WP_081130697.1|1361288_1362662_+|IS1380-family-transposase
MKDFPIRFVLTDEAITPSAGLALVGYLLHRTKLDKRVNALRLPTVRREVHISHSDVIRSMIGLLATGKTDFDHIEAYRQDDIFSASMGIQHVPSSPTLRQRLDQLACLPMTEAIIWEESMRLLVRQHATLSPCWTKGKTTWLPLDVDGSPFDNSDTKKEGVSRTYKGFDGFTPLFAYAGKEGYIVHAELRPGKQHVQDNMPSFLTTAIRRARPLTSSRLLVRMDAGNDAEANVHVCLKEDVDFVIKRNLRRESKALWFQIASQKGRRIDDGQTEGVQTYELCLPQKVAIDGNTYTYVQVTQVTERTMERNGQLMLVPNYEVESYWVRLEGYEHVRMSDVLALYHDHATCEQFHSELKSDLDLERLPSGKMKTNAIVLVMGAFVYNLLRLIGQDLLSDPRHPLHHKVKRRRIKTIIQTVITMAGLLVRRSRQIWMKLTRRSGYSEPLLNVYQKWREAR
>NZ_AP022557.1|WP_033843599.1|1363703_1365488_-|oligopeptide-ABC-transporter-substrate-binding-protein
MKQRWLAALAALLLVLAGCTGKSDTTSGKGNNNEKPAAQKEDTSKFPMTVKNDGKIIDGGVLKYGLVSDTPFEGTLNRAFYQGEPDAEVMQFFDESLFRINSDYEITNDGAATYELSKDKKTMTIRIKDNVNWHDGQPVTAEDLEYAYLVIGSKDYTGVRYGDALIQGIVGMEEYHSGKANKISGIKVIDKKTLTITWKQANPSVLTGIWAYPLPKHYLKDIPIKDLAKSDKIRKNPIGFGPFKVKKIVPGESVEFVRNDDYWDGKPKLKGVILKVVSPKVILQAMKKGEIDVAEFPTDQYVNAKGTKNIQFIGRIDLAYNYIGFKLGHWDAKKQENVMDNPKFQNKKLRQAMAYAINTQEVADRLYHGLRFPANTLIPPSFPGYHDNSIKGYTYNPEKAKQLLDEAGYKDVDGDGLREDPNGKKFKINFLAMSGGDIAEPLAKFYMQCWKDVGLDVQLVDGRLAEFNSFYDMVKKDDPKVEVYAAAWATGTDVDPYGLYGRNVMFNYSRWVNEKNDELLEKGHSEQAFDKEYRRKIYSEWQQLMNEEVPVIPTLYRFSILAVNNRVANFTVDPGSKLTWKDVGVTSEQPEVEQ
>NZ_AP022557.1|WP_033843598.1|1365500_1366409_-|ABC-transporter-permease
MKAEISGPTPAGANIEKSPSAFSIMWREVVRDRLALGSLIILGILLAIVYGVSLFLDQEEIVKVDFLSIYSPPSAEHWLGTDYGGRDVFGQLIIGARNSFTIGLAITLITGLIGLTIGLIAGYFGGWIDNVIMRVIDFILVLPFLMLVIVFVAIVPKYNVLTFILIMSAFLWTGKARLIRAKTLAERELDYVSASKTLGTPDWKIIIFQILPNLSSIIIVNLTLNLAGNIGIESGLTYLGFGLPESTPSLGTLVSYATNPDVLQNKWWVWLPASLLILVMMLCINFIGQALKRAADARQRLG
>NZ_AP022557.1|WP_033843597.1|1366430_1367399_-|ABC-transporter-permease
MLKFILRRILIMIPQLFLLSVLIFLLAKAMPGDALTGQLAANPKMDPKTLAEMKEKLGLNDPVHIQYIRWVKNMLHGDLGLSYTHQQPVTDLLAGRIGNTVLLSAAILILTYLIAIPLGIVSGRWTDTWADKLIIGYSYLGFATPLFIFALIMLFIFGFHLGWFPTGGSVDVQVEEGTLAYYLSKLNHLMLPALSGALINTVITIQYLRSEIVDTKVKDFVKTARAKGVPERHIYWRHILRNSFLPIAAFLGYEITGLIGGSVFLESIYSYPGLGQLFLQSIMQRDYSVVTALVMISGLATLVGTLLSDIILSAVDPRIRIE
>NZ_AP022557.1|WP_033843596.1|1367415_1368342_-|ABC-transporter-ATP-binding-protein
MALLNIQHLKVYYPVRGGFFRRVVDHVRAVDDVNFSLNKRETYGLVGESGCGKTTTGRTIIGLIRATAGEVLFEGTDLTKLRRREFHPYRKDIQMIFQDPYSSLNPRKRVLDIVAEPLRNFERLSPHEERQKVQYVLERVGLSAESIYKYPHEFSGGQRQRIGIARALTLNPKLIIADEPVSALDVSVQAQVLNFMKEIQQEYGLTYLFISHDLGIIRHMCDRIGIMYRGRLVEEGTSEEIFTNPQHIYTKRLLSAIPNADPRERGRQEALRREVEKEYEQSYSRYFDENGRAHPLKPISPTHSVAIP
>NZ_AP022557.1|WP_033843595.1|1368328_1369354_-|ABC-transporter-ATP-binding-protein
MAKQTLLEIEGLRVSFRIGDDYYAAVDDVSLAIGENEIVALVGESGCGKSALALSIMGLHPPEKTKIEGRLHFKGTNLLSLSVAELNRIRGKEIGMIFQDPLTALNPLMTVGRQIEESMDYHLRLSAAEKKKRTIGLLRKVGIPEPEKAYYRYPHELSGGMRQRVVIAIAIACEPALLIADEPTTALDVTIQAQIMGLLKELQRQMKTSVILITHDLGVVAEMADRVAVMYAGEIVELADVDAIFHRPLHPYTRSLLQSIPSAQTKKERLHVIQGIVPPLHKLPRHGCRFQPRIGWIGADKHEEEPKLREVEPGHWVRCTCYEHFYFPDDQTVGGIGYGAS
>NZ_AP022557.1|WP_033021715.1|1369656_1371147_-|glycerol-kinase-GlpK
MDQYILSIDQGTTSSRAILFNQKGEIVHMAQKEFTQYFPQPGWVEHNANEIWGSVLAVIASVLSEAQVKPEQVAAIGITNQRETTVVWEKESGNPIYNAIVWQSRQTAGICDELKAKGYDPLFREKTGLLIDAYFSGTKVKWILDHVEGARERAERGELLFGTIDTWLIWKLSGGRAHVTDYSNASRTLMFNIHTLEWDDELLAILNVPKAMLPEVRPSSQVYAKTVPYHFFGVEVPIAGAAGDQQAALFGQACFAEGMAKNTYGTGCFMLMNTGEKAVQSKHGLLTTIAWGIDGKVEYALEGSIFVAGSAIQWLRDGLRMIKTAADSETYAEKVESTDGVYVVPAFVGLGTPYWDSEVRGAVFGLTRGTTKEHFIRATLESLAYQTKDVLAAMEADSGLPLTTLRVDGGAVKNNLLMQFQSDLLAVPVERPVINETTALGAAYLAGLAVGYWDSREKIAAQWQLERRFEPKMDDAKRTALYEGWKKAVRAAMAFK
>NZ_AP022557.1|WP_033021716.1|1371214_1372033_-|aquaporin-family-protein
MSAFLGEFVGTALLIIFGAGVCAGVNLKKSYAANSGWIVITMGWGMAVAMAAYAVGKYSGAHLNPALTVALALSGDFPWKDVPGYVLAQVLGAMIGAAIIYLHYWPHWKETDDPGVKLGVFATGPAVPNPAANLLSEIIGTFVLVLVILAIGANKFADGLNPFVVGFLIVAIGLSLGGTTGYAINPARDFGPRLAHFLLPIPGKGSSNWSYAWVPIVGPLLGGALGSLVYKAVFLGKPTGALWGVLAATAVVLAGAKLTAGKASNVASRYSS
>NZ_AP022557.1|WP_172418571.1|1372765_1374202_+|DDE-type-integrase/transposase/recombinase
MLPQLLAYLLEIIKTQYQIIVYVMGVILGKSLHLEDWDEPVQKPYRKLQVDDLPIIDVPETLDYRKLLADYEAQHRRPLRPIQRRAKAKHRVPDSLTCPRCQAPSSYLYANHGGKGQYQCKVCQCRFNHRNRFTKQAVFRCPHCKKTLEKIKERKEYNIYKCKNNDCPFYQANLHRMTKKERQPFQQDPQAFKVRYWFREFLFDFLPLASSSLIKPKVDLSRLAASPHVLGLVLTYYVNFGMSSRETAAALKDIHGVSISHQTVLNYANSVALWIKPFVDRFPYELSGSFCGDETYIRVKGRWHYLFFLFDAVKKIVLSYRVSPNRDTLSAIKAIDDVLRKLASLPDDLSFVVDGNPIYRLAQHFFAQHGISFDVRQVIGLTNEDPVSEEFRPLKQIIERFNRTFKSNDRPTHGFGAEEGSVSFVTLFVAYFNFLRPHSALEGRVPVVIPELAELPHMPARWTKLIAMAQDFLQNEAA

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Crispr_ID: NZ_AP022557_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_11

1422324-1422414

Orphan

Consensus_repeat	Method
CTTGCCGCTCGTCCGTATATTCCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_11

>merge|NZ_AP022557|11|1422324-1422414|CRISPRCasFinder
CTTGCCGCTCGTCCGTATATTCCTGATCGCGCTCGGTGCCGAGCTCGTAGCCGCTGGACTGTTCGGCTTGCCGCTCGTCCATATATTCCTG

>NZ_AP022557|11|11|1422324-1422414|CRISPRCasFinder
CTTGCCGCTCGTCCGTATATTCCTG	ATCGCGCTCGGTGCCGAGCTCGTAGCCGCTGGACTGTTCGG
CTTGCCGCTCGTCCATATATTCCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843567.1\|1429278_1429893_+\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NZ_AP022557.1\|WP_033843575.1\|1414744_1414924_+\|aspartyl-phosphate-phosphatase-Spo0E-family-protein	unknown	unknown	gnl\|CDD\|378175
NZ_AP022557.1\|WP_033023223.1\|1418670_1418883_-\|YneF-family-protein	unknown	unknown	gnl\|CDD\|100947
NZ_AP022557.1\|WP_033844863.1\|1416784_1418548_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|182732
NZ_AP022557.1\|WP_033023231.1\|1413217_1413574_-\|response-regulator	unknown	unknown	gnl\|CDD\|381097
NZ_AP022557.1\|WP_033843572.1\|1419840_1421847_-\|transketolase	unknown	unknown	gnl\|CDD\|223100
NZ_AP022557.1\|WP_172418573.1\|1415009_1416788_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP022557.1\|WP_033023213.1\|1424628_1425963_-\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|273198
NZ_AP022557.1\|WP_033843568.1\|1427768_1429013_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|274455
NZ_AP022557.1\|WP_033023211.1\|1426002_1426404_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133380
NZ_AP022557.1\|WP_172418812.1\|1431006_1432158_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_AP022557.1\|WP_033023217.1\|1421964_1422195_-\|DUF896-domain-containing-protein	unknown	unknown	gnl\|CDD\|368690
NZ_AP022557.1\|WP_033023215.1\|1423508_1424132_+\|transcriptional-repressor-LexA	unknown	unknown	gnl\|CDD\|234688
NZ_AP022557.1\|WP_033023273.1\|1423051_1423357_-\|cell-division-suppressor-protein-YneA	unknown	unknown	gnl\|CDD\|184523
NZ_AP022557.1\|WP_033843573.1\|1418973_1419411_-\|sporulation-inhibitor-of-replication-protein-SirA	unknown	unknown	gnl\|CDD\|371220
NZ_AP022557.1\|WP_081897289.1\|1432353_1432425_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180269
NZ_AP022557.1\|WP_153017182.1\|1412622_1413096_-\|cytochrome-c-biogenesis-protein-CcdC	unknown	unknown	gnl\|CDD\|377808
NZ_AP022557.1\|WP_033843576.1\|1413679_1414387_-\|cytochrome-c-biogenesis-protein-CcdA	unknown	unknown	gnl\|CDD\|280792
NZ_AP022557.1\|WP_033843569.1\|1426480_1427752_-\|methionine-gamma-lyase-family-protein	unknown	unknown	gnl\|CDD\|311036
NZ_AP022557.1\|WP_033843566.1\|1429985_1430864_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033843567.1\|1429278_1429893_+\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	5.84197e-65
NZ_AP022557.1\|WP_033843575.1\|1414744_1414924_+\|aspartyl-phosphate-phosphatase-Spo0E-family-protein	gnl\|CDD\|378175	pfam09388, SpoOE-like, Spo0E like sporulation regulatory protein. Spore formation is an extreme response to starvation and can also be a component of disease transmission. Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A. Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation. This is a family of Spo0E-like phosphatases. The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure.	8.78021e-08
NZ_AP022557.1\|WP_033023223.1\|1418670_1418883_-\|YneF-family-protein	gnl\|CDD\|100947	PRK01844, PRK01844, YneF family protein.	4.30682e-21
NZ_AP022557.1\|WP_033844863.1\|1416784_1418548_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|182732	PRK10789, PRK10789, SmdA family multidrug ABC transporter permease/ATP-binding protein.	0
NZ_AP022557.1\|WP_033023231.1\|1413217_1413574_-\|response-regulator	gnl\|CDD\|381097	cd17542, REC_CheY, phosphoacceptor receiver (REC) domain of chemotaxis protein CheY. The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.14776e-54
NZ_AP022557.1\|WP_033843572.1\|1419840_1421847_-\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NZ_AP022557.1\|WP_172418573.1\|1415009_1416788_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	6.60075e-179
NZ_AP022557.1\|WP_033023213.1\|1424628_1425963_-\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_AP022557.1\|WP_033843568.1\|1427768_1429013_-\|GTPase-HflX	gnl\|CDD\|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	0
NZ_AP022557.1\|WP_033023211.1\|1426002_1426404_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133380	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators. Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	4.43812e-25
NZ_AP022557.1\|WP_172418812.1\|1431006_1432158_-\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	0
NZ_AP022557.1\|WP_033023217.1\|1421964_1422195_-\|DUF896-domain-containing-protein	gnl\|CDD\|368690	pfam05979, DUF896, Bacterial protein of unknown function (DUF896). In B. subtilis, one small SOS response operon under the control of LexA, the yneA operon, is comprised of three genes: yneA, yneB, and ynzC. This family consists of several short, hypothetical bacterial proteins of unknown function. These proteins are mainly found in gram-positive firmicutes. Structures show that the N-terminus is composed of two alpha helices forming a helix-loop-helix motif. The structure of ynzC from B. subtilis forms a trimeric complex. Structural modelling suggests this domain may bind nucleic acids. This family is also known as UPF0291.	7.16426e-30
NZ_AP022557.1\|WP_033023215.1\|1423508_1424132_+\|transcriptional-repressor-LexA	gnl\|CDD\|234688	PRK00215, PRK00215, transcriptional repressor LexA.	1.85e-116
NZ_AP022557.1\|WP_033023273.1\|1423051_1423357_-\|cell-division-suppressor-protein-YneA	gnl\|CDD\|184523	PRK14125, PRK14125, cell division suppressor protein YneA; Provisional.	5.91263e-47
NZ_AP022557.1\|WP_033843573.1\|1418973_1419411_-\|sporulation-inhibitor-of-replication-protein-SirA	gnl\|CDD\|371220	pfam10747, SirA, Sporulation inhibitor of replication protein SirA. This entry represents the Sporulation inhibitor of replication (sirA) family of proteins from Bacillus sp. Induction of sporulation in rapidly growing cells inhibits replication; this is thought to be through the action of SirA protein and independent of phosphorylated Spo0A; however SirA protein synthesis is induced by Spo0A.	1.93294e-42
NZ_AP022557.1\|WP_081897289.1\|1432353_1432425_-\|hypothetical-protein	gnl\|CDD\|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	1.25842e-08
NZ_AP022557.1\|WP_153017182.1\|1412622_1413096_-\|cytochrome-c-biogenesis-protein-CcdC	gnl\|CDD\|377808	pfam07301, DUF1453, Protein of unknown function (DUF1453). This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown. Members of this family seem to be found exclusively in the Order Bacillales.	2.90163e-61
NZ_AP022557.1\|WP_033843576.1\|1413679_1414387_-\|cytochrome-c-biogenesis-protein-CcdA	gnl\|CDD\|280792	pfam02683, DsbD, Cytochrome C biogenesis protein transmembrane region. This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.	2.00675e-52
NZ_AP022557.1\|WP_033843569.1\|1426480_1427752_-\|methionine-gamma-lyase-family-protein	gnl\|CDD\|311036	pfam06838, Met_gamma_lyase, Methionine gamma-lyase. This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.	0
NZ_AP022557.1\|WP_033843566.1\|1429985_1430864_-\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.4365e-22

>NZ_AP022557.1|WP_033023217.1|1421964_1422195_-|DUF896-domain-containing-protein
MLAKQKLDRINELAKKAKTSGLTAEETIEQAKLRREYIQAFRKAMTDMLHTVTVIDPNGNDVTPKKLKESQRRRLH
>NZ_AP022557.1|WP_033843572.1|1419840_1421847_-|transketolase
MAHSIEELAITTIRTLSIDAIEKAKSGHPGMPMGAAPMAYVLWTKWMNHNPANPNWFNRDRFVLSAGHGSMLLYSLLHLSGYDVSMDDLKQFRQWGSKTPGHPEYGHTPGVEATTGPLGQGIAMAVGMAMAERHLAATYNRDGFPIIDHYTYAICGDGDFMEGVASEAASLAGHLQLGRLIVLYDSNDISLDGELNLSFSENVAQRFQAYGWQYLRVEDGNNIEEIAKALEEARADLSRPTLIEVKTTIGYGAPTKAGTSGVHGAPLGAEEAKLTKEAYRWTFAEDFYVPEEVYAHFRETVQEPGAKKEAEWNELFAAYEQAHPELAAQLKQAIAGTLPAGWEAVLPVYEAGKSLATRSSSGEVINAIAKAVPQLFGGSADLASSNKTLIKGGGNFLPGSYEGRNIWFGVREFAMGAALNGMALHGGLKVFGGTFFVFSDYLRPAIRLAALMGLPVTYVLTHDSIAVGEDGPTHEPVEHLASLRAMPNLSVIRPADANETAAAWRLALEATDKPTALVLTRQDVPTLPQTAELAYEGVKKGAYVVSPAKNGAPEALLLATGSEVSLAVNAQEALAAEGIHVSVISMPSWDRFEAQPKAYRDEVIPPTVTKRLAIEMGASLGWERYVGHEGDVLAIDRFGASAPGEKIMAEYGFTVDHVVRRVKALLGK
>NZ_AP022557.1|WP_033843573.1|1418973_1419411_-|sporulation-inhibitor-of-replication-protein-SirA
MVRYWIYLLKDEVAAHYRHRTEKIVELLREHQHAKAPLKAICRKQVEFITERLSFSRLELGLKQSFTGRVGKNLERNMFILRHESGEEALLVVQKRRLLLVADSATLAADIGRALAKLAPTFLAVAADFADYHWLCAPALGRKFA
>NZ_AP022557.1|WP_033023223.1|1418670_1418883_-|YneF-family-protein
MWDTILVGVLALIAGVAIGFFIARKTMINYLKKNPPINEQMIRMMMMQMGMTPSQKKINQMMKMMNNQLK
>NZ_AP022557.1|WP_033844863.1|1416784_1418548_-|ATP-binding-cassette-domain-containing-protein
MRVFRDLFWFFRQEKKAYMTGVLLLVVVAFFETVPPKVIGILVDHMKNGTMTRGVLVRWLAVLAVVAAALYGLRYAWRICIFGAAVKLTRQLRNELYEHFTKMSPSFYQRKRIGDLMAHATNDLQAIQQTAGSGILTLVDSLTLGGFVLATMAVSISWKLTVISLLPLPVMAVATSRYGAILHRRFVTAQEAFSSLNDKVQESISGVRVIKAFGYEKQDVEAFRRQSEDVVAKNIAVAKIDALFDPTIGFLVGLSFFLAVAFGSEMVLTGELTIGELVSFTTYLGLLIWPMLAFGWLFNIVERGRASYDRVRALLAEQDEIQEASDAIDVPPRGDIEYDIKRFAYPGEMRTALSDIRFRLKSGATLGVVGKTGAGKTTLLRLLLREFDGYDGEIRFGGHDIRSYTLSALRSAIGYVPQDHFLFSASVRDNIAFAQLEAEEKEIVRAAQLAHIHEDILQFPDGYATVVGERGVSLSGGQKQRLSIARALLTNPEVLILDDALSAVDAKTEARILAALKQERRGKTTIIAAHRLSAVEHADWIVVLDGGRIVQAGTHEKLVAEDGWYRDMHQRQQLEAFVEGPQIGGMA
>NZ_AP022557.1|WP_172418573.1|1415009_1416788_-|ABC-transporter-ATP-binding-protein
MNGQTLTAKEQRRVLWRLLSYMGRYKKEAALALFLLLLSTAGELAGPYLVKVFIDDYLMPGRLAFEPVEALAAAYLGMLGAKTVITYFQLVEFQRLALYIIQALRMDVFSKVHRLGMSYFDRTPGGSIVSRVTNDTEAIKDMFISVLAVFVQNGLFVIGVFIAMFVLNVRLALFCLFILPAIALIMRTYRRYSSVFYQDMRERLSELNAKLNESLQGMAIIQAFRQQQRLYREFAAVNEAHYRAGMRNIRLDGLLLRPAIDVIYMASIMVVLGFFGISALESPVEIGVLYAFVNYLERFFEPVTQMMMRLSLYQQAIVSASRVFALLDREEEAPFHPEQAPYTIERGEIEFRDVSFSYDGKRDVIKRVSFVIHPGQTVAFVGHTGSGKSSIINLLMRFYEFDRGDILLDGRSIRDYSRTELRRRLGLVLQDPFLFYGTVRDNIRMYNEAIDEERVRAAARLVQAEPFIERLPGGYDHVLAERGATLSSGQRQLLSFARTIAADPKILVLDEATAHIDTETEEAIQEALARMRKGRTTLVIAHRLSTVQDADQIFVLKRGEIVERGTHQQLLAQRGIYYQMYLLQNGLVDARR
>NZ_AP022557.1|WP_033843575.1|1414744_1414924_+|aspartyl-phosphate-phosphatase-Spo0E-family-protein
MPKQSLLTLIEQKRMELVDIVAKTGLNSPAAMKISKELDTLLNAYQREQRNERKQSAPR
>NZ_AP022557.1|WP_033843576.1|1413679_1414387_-|cytochrome-c-biogenesis-protein-CcdA
MNQLNVFLAFGAGFLSFLSPCTLPLYPAFLSYITGMSVSELKEENAMLNRRSLWHTGCFLLGFSLIFVSLGFGTSLIGRLFVDYQDVIRQIGAVVIAALGLVVAGVWKPGFLLQDRRVSFRERPSGYVGSMLIGMAFAAGWTPCMGPILVAVVALAATHPGSGILYMLAYALGFAVPFFILSFFLGKLQWIHRHSASMMKAGGYVMIAMGVILYFDWMTKLIGYATSLFGGFTGF
>NZ_AP022557.1|WP_033023231.1|1413217_1413574_-|response-regulator
MASVLVVDDAKFMRVTLARILQKGHHEVAGEAENGKDAVELYRRLRPDLVIMDITMPVMNGIEAVRAIKELDPGAKIIICSALGQQRMVVEAVEAGAADFIVKPFEEQRVLEAVARLL
>NZ_AP022557.1|WP_153017182.1|1412622_1413096_-|cytochrome-c-biogenesis-protein-CcdC
MTLVTSLIAVVMAFLVFFVRIKASEKPTNAKKIILPPLFMSTGALMFIDPVFRVTRGELIEAVVLGLFFSLFLIKTSKFEVRGHDIYLKRSKAFIWILLGLIIIRLGLKTYLGRTIDYRQLSGMFYLLAFSMIVPWRIAMYVSYRKLAARLKPPVLT
>NZ_AP022557.1|WP_033023273.1|1423051_1423357_-|cell-division-suppressor-protein-YneA
MKKTFVHYLVFSVLMTLFTAAFIYAGSPVDKQEYVTVTVASGDTLWGLAKQYEQEHGLSPDEFIRWVVEVNHLRSSRLTAGEQIVIPVLKSKRGGSLAANQ
>NZ_AP022557.1|WP_033023215.1|1423508_1424132_+|transcriptional-repressor-LexA
MTKLSKRQQQILEFIKQEVKTKGYPPSVREIGEAVGLASSSTVHGHLARLESKGYIRRDPTKPRAIEILDNDGGKEKEGEDIVSVPIIGKVTAGQPITAVENIEDYFPLPKRLAAGEEQLFMLEVMGDSMIEAGILDGDYVIVRQQSSAQNGDIVVAMTEDNEATVKRFFKEKDHIRLQPENAHLEPIIVRDCTILGKVIGVYRLIG
>NZ_AP022557.1|WP_033023213.1|1424628_1425963_-|type-I-glutamate--ammonia-ligase
MAKYTREDIMRIVKEENVKYIRLQFTDILGTIKNVEIPISQLEKALNNKMMFDGSSIEGFVRIEESDMYLYPDLDTFVIFPWTAEKGKVARFICDIYNADGTPFEGCPRYNLKRVLKEMEALGFTAFNLGAEPEFFLFKLDEKGHPTMELNDRGGYFDLAPTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAHAIKACDDIQTFKLVVKTIARKHGLHATFMPKPIFGINGSGMHCNLSLFRNGENAFFDPNGELQLSETARQFIAGVLKHAPNFTAVTNPTVNSYKRLVPGYEAPCYVAWSARNRSPLIRIPASRGMSTRIEVRSVDPSANPYLAMAVLLAAGLDGIRNKLTPPAPVDRNIYVMTKEERLEEGIVDLPATLIEALENLKSDEVIVQALGKHLFEHFVEAKEIEWDMYRTTVHQWELDQYMELY
>NZ_AP022557.1|WP_033023211.1|1426002_1426404_-|MerR-family-transcriptional-regulator
MSSQIRRSMPLFPIGIVMQLTDLSARQIRYYEEHGLVTPARTEGNRRLFSLNDIDRLLEIKDLIDQGVNLAGIKRIFAARQEGRHEQPEKVDKAGKPKLSDEELREILRTELLQAGRFQRASLRQGDLARFFH
>NZ_AP022557.1|WP_033843569.1|1426480_1427752_-|methionine-gamma-lyase-family-protein
MFWTTWKHGETIAALIEEVEAQIAPIHRSIERLVDGNQHRVLDSFRRHQVSDGHFIPTTGYGYDDVGRDTLDRIYADVFGAEAGLVRPQIISGTHAIAIALFGVLRPGDELLYITGAPYDTLEEIVGVRGRGVGSLNEFGIRYRSVPLTADGAVDFPAVREAIHERTKMIGIQRSRGYATRPSFTVDEIAKMIAFVKAIKPDVVVFVDNCYGEFVEEKEPCHVGADLMAGSLIKNPGGGLAKTGGYIVGRHQYVEACAYRMTSPGIGAEVGPSLYSLLEMYQGFFLAPHVVGQALKGAVFTAALLERVGLETSPSWNAKRTDLVQSVRFNDPEQMVAFCQAIQAASPVNAHFTPYPSDMPGYEDQVIMAAGTFVQGASIELTADGPLRPPYVAYVQGGLTYSHVKIAVCSAVHRLLEQQLICL
>NZ_AP022557.1|WP_033843568.1|1427768_1429013_-|GTPase-HflX
MSREQAIIVGCQLHGIDDERFRYSMEELAALVATANGEVVAELTQKREAPHPATYIGKGKTEELAALVKQLTPDLVIFNSELSPSQARNLTNMLGEVKVIDRTQLILDIFARRARSKEGKLQVELAQLEYLLPRLGGQGAALSRLGGGIGTRGPGETKLETDRRHIRRRIDDIKAELRRIAEHRERYRGRRQKNHAFQVALVGYTNAGKSTIFNRLTAADSFEENLLFATLDPLTRQCVLPCGYTVLVTDTVGFIQDLPTTLVAAFRSTLEEVTEADLLLHIVDSSHPDYAEHERTVLQLVAELGASSIPMVTVYNKRDRQAPEFIPTTTEALVMSALSAADIERLRAFLEEAIKRQMVLYHASIPSGQGKWLARLKADTILQQWRYNEQEGTYECEGYVLPTHPLYRELQSFQ
>NZ_AP022557.1|WP_033843567.1|1429278_1429893_+|trimeric-intracellular-cation-channel-family-protein
MTWEILSIIGTIAFAISGAIVAMEEEYDLLGVYILGIVTAFGGGAVRNLLIGVPVSALWEQGSLFLVALVSMTIVYLFPKQMLPPWKRWGNFFDALGLSAFAIQGALYAAKMGHPLSAVIVAAVLTGSGGGIIRDVLAGRKPLVLHAEIYAAWAILAGIAVGLKWAESPVELYVLFIAVAALRILSYTYGWKLPRRAVGEKAGG
>NZ_AP022557.1|WP_033843566.1|1429985_1430864_-|DMT-family-transporter
MKQPVLASIYLSLAAGIWGGMYVVSKYVLDYIPPLTLVWLRYGVALIALVLIAAMKRERPPTRGRDWLMVIAIGVIGYVISISLQFVGTKWSNAHTASLITASTPAFVVLFARWLLGEALTWRKLVALVLAAAGVVVIVGLGDSGESTLAGNTALVGAAVTWALLSVLVKMASARMSVLSITTFAILVAFVGMTPMLMVERPGLTAVQWNAPVAMGVLYLGIVSTAGAFFLWNKGMEMIDAGIGSLFFLFQPLIGSLFGWLFLHERLDASFWMGGALIVAGVAVAVRSGQSA
>NZ_AP022557.1|WP_172418812.1|1431006_1432158_-|thiolase-family-protein
MMREAVIVEAVRTPVGKRNGVFRDVHPVHLAAAVLDEVVRRAGIEKGQVEDIVMGCVTPIAEQGYNIGRLAALEAGFPIEVPAVQINRMCGSGQQAIHFAAQEIRSGDMDVTIAAGVESMTKVPIFSDGNERTIPPSLHEKYEFIHQGVSAERIAKKYGLTRAEVDAYAYESHRRALAAMRARKFRAEIVPVKGLDRDGREILVTDDEGARADTSPEALAALKPVFQEDGVITAGNASQMSDGAAALLLMEREAARRFGLKPKARIVAQTVVGSDPTYMLDGVIPATRQVLKKAGLTIEDIDLIEINEVFAPVVLAWQKEIGAPLAKVNVNGGAIALGHPLGATGVKLMTSLVHELERREGRYGLLTICIGHGMATATIIERM
>NZ_AP022557.1|WP_081897289.1|1432353_1432425_-|hypothetical-protein
MRKLVEAGHLGRKTGKGFYTYTT

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Crispr_ID: NZ_AP022557_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_12

1424377-1424505

Orphan

Consensus_repeat	Method
GGCACAACCAATCATGGGCCGGAAGCACCGGTACGTATATAAAAGAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_12

>merge|NZ_AP022557|12|1424377-1424505|CRISPRCasFinder
GGCACAACCAATCATGGGCCGGAAGCACCGGTACGTATATAAAAGAGGAGCTAACCCAAAAGATTGCCTGCCTTCAAGATCGGCACAACCAATCATGGGCCGGAAGCACCGGTACCTATATAAAAGAGG

>NZ_AP022557|12|12|1424377-1424505|CRISPRCasFinder
GGCACAACCAATCATGGGCCGGAAGCACCGGTACGTATATAAAAGAGG	AGCTAACCCAAAAGATTGCCTGCCTTCAAGATC
GGCACAACCAATCATGGGCCGGAAGCACCGGTACCTATATAAAAGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843567.1\|1429278_1429893_+\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NZ_AP022557.1\|WP_033843575.1\|1414744_1414924_+\|aspartyl-phosphate-phosphatase-Spo0E-family-protein	unknown	unknown	gnl\|CDD\|378175
NZ_AP022557.1\|WP_033843564.1\|1432681_1434301_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341284
NZ_AP022557.1\|WP_033023223.1\|1418670_1418883_-\|YneF-family-protein	unknown	unknown	gnl\|CDD\|100947
NZ_AP022557.1\|WP_033844863.1\|1416784_1418548_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|182732
NZ_AP022557.1\|WP_033843572.1\|1419840_1421847_-\|transketolase	unknown	unknown	gnl\|CDD\|223100
NZ_AP022557.1\|WP_033023273.1\|1423051_1423357_-\|cell-division-suppressor-protein-YneA	unknown	unknown	gnl\|CDD\|184523
NZ_AP022557.1\|WP_033023213.1\|1424628_1425963_-\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|273198
NZ_AP022557.1\|WP_033843568.1\|1427768_1429013_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|274455
NZ_AP022557.1\|WP_172418812.1\|1431006_1432158_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_AP022557.1\|WP_033023217.1\|1421964_1422195_-\|DUF896-domain-containing-protein	unknown	unknown	gnl\|CDD\|368690
NZ_AP022557.1\|WP_033843563.1\|1434304_1435378_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_AP022557.1\|WP_033023215.1\|1423508_1424132_+\|transcriptional-repressor-LexA	unknown	unknown	gnl\|CDD\|234688
NZ_AP022557.1\|WP_172418573.1\|1415009_1416788_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP022557.1\|WP_033843573.1\|1418973_1419411_-\|sporulation-inhibitor-of-replication-protein-SirA	unknown	unknown	gnl\|CDD\|371220
NZ_AP022557.1\|WP_081897289.1\|1432353_1432425_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180269
NZ_AP022557.1\|WP_033023211.1\|1426002_1426404_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133380
NZ_AP022557.1\|WP_033843576.1\|1413679_1414387_-\|cytochrome-c-biogenesis-protein-CcdA	unknown	unknown	gnl\|CDD\|280792
NZ_AP022557.1\|WP_033843569.1\|1426480_1427752_-\|methionine-gamma-lyase-family-protein	unknown	unknown	gnl\|CDD\|311036
NZ_AP022557.1\|WP_033843566.1\|1429985_1430864_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033843567.1\|1429278_1429893_+\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	5.84197e-65
NZ_AP022557.1\|WP_033843575.1\|1414744_1414924_+\|aspartyl-phosphate-phosphatase-Spo0E-family-protein	gnl\|CDD\|378175	pfam09388, SpoOE-like, Spo0E like sporulation regulatory protein. Spore formation is an extreme response to starvation and can also be a component of disease transmission. Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A. Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation. This is a family of Spo0E-like phosphatases. The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure.	8.78021e-08
NZ_AP022557.1\|WP_033843564.1\|1432681_1434301_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341284	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles. This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.	0
NZ_AP022557.1\|WP_033023223.1\|1418670_1418883_-\|YneF-family-protein	gnl\|CDD\|100947	PRK01844, PRK01844, YneF family protein.	4.30682e-21
NZ_AP022557.1\|WP_033844863.1\|1416784_1418548_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|182732	PRK10789, PRK10789, SmdA family multidrug ABC transporter permease/ATP-binding protein.	0
NZ_AP022557.1\|WP_033843572.1\|1419840_1421847_-\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NZ_AP022557.1\|WP_033023273.1\|1423051_1423357_-\|cell-division-suppressor-protein-YneA	gnl\|CDD\|184523	PRK14125, PRK14125, cell division suppressor protein YneA; Provisional.	5.91263e-47
NZ_AP022557.1\|WP_033023213.1\|1424628_1425963_-\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_AP022557.1\|WP_033843568.1\|1427768_1429013_-\|GTPase-HflX	gnl\|CDD\|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	0
NZ_AP022557.1\|WP_172418812.1\|1431006_1432158_-\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	0
NZ_AP022557.1\|WP_033023217.1\|1421964_1422195_-\|DUF896-domain-containing-protein	gnl\|CDD\|368690	pfam05979, DUF896, Bacterial protein of unknown function (DUF896). In B. subtilis, one small SOS response operon under the control of LexA, the yneA operon, is comprised of three genes: yneA, yneB, and ynzC. This family consists of several short, hypothetical bacterial proteins of unknown function. These proteins are mainly found in gram-positive firmicutes. Structures show that the N-terminus is composed of two alpha helices forming a helix-loop-helix motif. The structure of ynzC from B. subtilis forms a trimeric complex. Structural modelling suggests this domain may bind nucleic acids. This family is also known as UPF0291.	7.16426e-30
NZ_AP022557.1\|WP_033843563.1\|1434304_1435378_-\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	2.80827e-96
NZ_AP022557.1\|WP_033023215.1\|1423508_1424132_+\|transcriptional-repressor-LexA	gnl\|CDD\|234688	PRK00215, PRK00215, transcriptional repressor LexA.	1.85e-116
NZ_AP022557.1\|WP_172418573.1\|1415009_1416788_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	6.60075e-179
NZ_AP022557.1\|WP_033843573.1\|1418973_1419411_-\|sporulation-inhibitor-of-replication-protein-SirA	gnl\|CDD\|371220	pfam10747, SirA, Sporulation inhibitor of replication protein SirA. This entry represents the Sporulation inhibitor of replication (sirA) family of proteins from Bacillus sp. Induction of sporulation in rapidly growing cells inhibits replication; this is thought to be through the action of SirA protein and independent of phosphorylated Spo0A; however SirA protein synthesis is induced by Spo0A.	1.93294e-42
NZ_AP022557.1\|WP_081897289.1\|1432353_1432425_-\|hypothetical-protein	gnl\|CDD\|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	1.25842e-08
NZ_AP022557.1\|WP_033023211.1\|1426002_1426404_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133380	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators. Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	4.43812e-25
NZ_AP022557.1\|WP_033843576.1\|1413679_1414387_-\|cytochrome-c-biogenesis-protein-CcdA	gnl\|CDD\|280792	pfam02683, DsbD, Cytochrome C biogenesis protein transmembrane region. This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.	2.00675e-52
NZ_AP022557.1\|WP_033843569.1\|1426480_1427752_-\|methionine-gamma-lyase-family-protein	gnl\|CDD\|311036	pfam06838, Met_gamma_lyase, Methionine gamma-lyase. This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.	0
NZ_AP022557.1\|WP_033843566.1\|1429985_1430864_-\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.4365e-22

>NZ_AP022557.1|WP_033023215.1|1423508_1424132_+|transcriptional-repressor-LexA
MTKLSKRQQQILEFIKQEVKTKGYPPSVREIGEAVGLASSSTVHGHLARLESKGYIRRDPTKPRAIEILDNDGGKEKEGEDIVSVPIIGKVTAGQPITAVENIEDYFPLPKRLAAGEEQLFMLEVMGDSMIEAGILDGDYVIVRQQSSAQNGDIVVAMTEDNEATVKRFFKEKDHIRLQPENAHLEPIIVRDCTILGKVIGVYRLIG
>NZ_AP022557.1|WP_033023273.1|1423051_1423357_-|cell-division-suppressor-protein-YneA
MKKTFVHYLVFSVLMTLFTAAFIYAGSPVDKQEYVTVTVASGDTLWGLAKQYEQEHGLSPDEFIRWVVEVNHLRSSRLTAGEQIVIPVLKSKRGGSLAANQ
>NZ_AP022557.1|WP_033023217.1|1421964_1422195_-|DUF896-domain-containing-protein
MLAKQKLDRINELAKKAKTSGLTAEETIEQAKLRREYIQAFRKAMTDMLHTVTVIDPNGNDVTPKKLKESQRRRLH
>NZ_AP022557.1|WP_033843572.1|1419840_1421847_-|transketolase
MAHSIEELAITTIRTLSIDAIEKAKSGHPGMPMGAAPMAYVLWTKWMNHNPANPNWFNRDRFVLSAGHGSMLLYSLLHLSGYDVSMDDLKQFRQWGSKTPGHPEYGHTPGVEATTGPLGQGIAMAVGMAMAERHLAATYNRDGFPIIDHYTYAICGDGDFMEGVASEAASLAGHLQLGRLIVLYDSNDISLDGELNLSFSENVAQRFQAYGWQYLRVEDGNNIEEIAKALEEARADLSRPTLIEVKTTIGYGAPTKAGTSGVHGAPLGAEEAKLTKEAYRWTFAEDFYVPEEVYAHFRETVQEPGAKKEAEWNELFAAYEQAHPELAAQLKQAIAGTLPAGWEAVLPVYEAGKSLATRSSSGEVINAIAKAVPQLFGGSADLASSNKTLIKGGGNFLPGSYEGRNIWFGVREFAMGAALNGMALHGGLKVFGGTFFVFSDYLRPAIRLAALMGLPVTYVLTHDSIAVGEDGPTHEPVEHLASLRAMPNLSVIRPADANETAAAWRLALEATDKPTALVLTRQDVPTLPQTAELAYEGVKKGAYVVSPAKNGAPEALLLATGSEVSLAVNAQEALAAEGIHVSVISMPSWDRFEAQPKAYRDEVIPPTVTKRLAIEMGASLGWERYVGHEGDVLAIDRFGASAPGEKIMAEYGFTVDHVVRRVKALLGK
>NZ_AP022557.1|WP_033843573.1|1418973_1419411_-|sporulation-inhibitor-of-replication-protein-SirA
MVRYWIYLLKDEVAAHYRHRTEKIVELLREHQHAKAPLKAICRKQVEFITERLSFSRLELGLKQSFTGRVGKNLERNMFILRHESGEEALLVVQKRRLLLVADSATLAADIGRALAKLAPTFLAVAADFADYHWLCAPALGRKFA
>NZ_AP022557.1|WP_033023223.1|1418670_1418883_-|YneF-family-protein
MWDTILVGVLALIAGVAIGFFIARKTMINYLKKNPPINEQMIRMMMMQMGMTPSQKKINQMMKMMNNQLK
>NZ_AP022557.1|WP_033844863.1|1416784_1418548_-|ATP-binding-cassette-domain-containing-protein
MRVFRDLFWFFRQEKKAYMTGVLLLVVVAFFETVPPKVIGILVDHMKNGTMTRGVLVRWLAVLAVVAAALYGLRYAWRICIFGAAVKLTRQLRNELYEHFTKMSPSFYQRKRIGDLMAHATNDLQAIQQTAGSGILTLVDSLTLGGFVLATMAVSISWKLTVISLLPLPVMAVATSRYGAILHRRFVTAQEAFSSLNDKVQESISGVRVIKAFGYEKQDVEAFRRQSEDVVAKNIAVAKIDALFDPTIGFLVGLSFFLAVAFGSEMVLTGELTIGELVSFTTYLGLLIWPMLAFGWLFNIVERGRASYDRVRALLAEQDEIQEASDAIDVPPRGDIEYDIKRFAYPGEMRTALSDIRFRLKSGATLGVVGKTGAGKTTLLRLLLREFDGYDGEIRFGGHDIRSYTLSALRSAIGYVPQDHFLFSASVRDNIAFAQLEAEEKEIVRAAQLAHIHEDILQFPDGYATVVGERGVSLSGGQKQRLSIARALLTNPEVLILDDALSAVDAKTEARILAALKQERRGKTTIIAAHRLSAVEHADWIVVLDGGRIVQAGTHEKLVAEDGWYRDMHQRQQLEAFVEGPQIGGMA
>NZ_AP022557.1|WP_172418573.1|1415009_1416788_-|ABC-transporter-ATP-binding-protein
MNGQTLTAKEQRRVLWRLLSYMGRYKKEAALALFLLLLSTAGELAGPYLVKVFIDDYLMPGRLAFEPVEALAAAYLGMLGAKTVITYFQLVEFQRLALYIIQALRMDVFSKVHRLGMSYFDRTPGGSIVSRVTNDTEAIKDMFISVLAVFVQNGLFVIGVFIAMFVLNVRLALFCLFILPAIALIMRTYRRYSSVFYQDMRERLSELNAKLNESLQGMAIIQAFRQQQRLYREFAAVNEAHYRAGMRNIRLDGLLLRPAIDVIYMASIMVVLGFFGISALESPVEIGVLYAFVNYLERFFEPVTQMMMRLSLYQQAIVSASRVFALLDREEEAPFHPEQAPYTIERGEIEFRDVSFSYDGKRDVIKRVSFVIHPGQTVAFVGHTGSGKSSIINLLMRFYEFDRGDILLDGRSIRDYSRTELRRRLGLVLQDPFLFYGTVRDNIRMYNEAIDEERVRAAARLVQAEPFIERLPGGYDHVLAERGATLSSGQRQLLSFARTIAADPKILVLDEATAHIDTETEEAIQEALARMRKGRTTLVIAHRLSTVQDADQIFVLKRGEIVERGTHQQLLAQRGIYYQMYLLQNGLVDARR
>NZ_AP022557.1|WP_033843575.1|1414744_1414924_+|aspartyl-phosphate-phosphatase-Spo0E-family-protein
MPKQSLLTLIEQKRMELVDIVAKTGLNSPAAMKISKELDTLLNAYQREQRNERKQSAPR
>NZ_AP022557.1|WP_033843576.1|1413679_1414387_-|cytochrome-c-biogenesis-protein-CcdA
MNQLNVFLAFGAGFLSFLSPCTLPLYPAFLSYITGMSVSELKEENAMLNRRSLWHTGCFLLGFSLIFVSLGFGTSLIGRLFVDYQDVIRQIGAVVIAALGLVVAGVWKPGFLLQDRRVSFRERPSGYVGSMLIGMAFAAGWTPCMGPILVAVVALAATHPGSGILYMLAYALGFAVPFFILSFFLGKLQWIHRHSASMMKAGGYVMIAMGVILYFDWMTKLIGYATSLFGGFTGF
>NZ_AP022557.1|WP_033023213.1|1424628_1425963_-|type-I-glutamate--ammonia-ligase
MAKYTREDIMRIVKEENVKYIRLQFTDILGTIKNVEIPISQLEKALNNKMMFDGSSIEGFVRIEESDMYLYPDLDTFVIFPWTAEKGKVARFICDIYNADGTPFEGCPRYNLKRVLKEMEALGFTAFNLGAEPEFFLFKLDEKGHPTMELNDRGGYFDLAPTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAHAIKACDDIQTFKLVVKTIARKHGLHATFMPKPIFGINGSGMHCNLSLFRNGENAFFDPNGELQLSETARQFIAGVLKHAPNFTAVTNPTVNSYKRLVPGYEAPCYVAWSARNRSPLIRIPASRGMSTRIEVRSVDPSANPYLAMAVLLAAGLDGIRNKLTPPAPVDRNIYVMTKEERLEEGIVDLPATLIEALENLKSDEVIVQALGKHLFEHFVEAKEIEWDMYRTTVHQWELDQYMELY
>NZ_AP022557.1|WP_033023211.1|1426002_1426404_-|MerR-family-transcriptional-regulator
MSSQIRRSMPLFPIGIVMQLTDLSARQIRYYEEHGLVTPARTEGNRRLFSLNDIDRLLEIKDLIDQGVNLAGIKRIFAARQEGRHEQPEKVDKAGKPKLSDEELREILRTELLQAGRFQRASLRQGDLARFFH
>NZ_AP022557.1|WP_033843569.1|1426480_1427752_-|methionine-gamma-lyase-family-protein
MFWTTWKHGETIAALIEEVEAQIAPIHRSIERLVDGNQHRVLDSFRRHQVSDGHFIPTTGYGYDDVGRDTLDRIYADVFGAEAGLVRPQIISGTHAIAIALFGVLRPGDELLYITGAPYDTLEEIVGVRGRGVGSLNEFGIRYRSVPLTADGAVDFPAVREAIHERTKMIGIQRSRGYATRPSFTVDEIAKMIAFVKAIKPDVVVFVDNCYGEFVEEKEPCHVGADLMAGSLIKNPGGGLAKTGGYIVGRHQYVEACAYRMTSPGIGAEVGPSLYSLLEMYQGFFLAPHVVGQALKGAVFTAALLERVGLETSPSWNAKRTDLVQSVRFNDPEQMVAFCQAIQAASPVNAHFTPYPSDMPGYEDQVIMAAGTFVQGASIELTADGPLRPPYVAYVQGGLTYSHVKIAVCSAVHRLLEQQLICL
>NZ_AP022557.1|WP_033843568.1|1427768_1429013_-|GTPase-HflX
MSREQAIIVGCQLHGIDDERFRYSMEELAALVATANGEVVAELTQKREAPHPATYIGKGKTEELAALVKQLTPDLVIFNSELSPSQARNLTNMLGEVKVIDRTQLILDIFARRARSKEGKLQVELAQLEYLLPRLGGQGAALSRLGGGIGTRGPGETKLETDRRHIRRRIDDIKAELRRIAEHRERYRGRRQKNHAFQVALVGYTNAGKSTIFNRLTAADSFEENLLFATLDPLTRQCVLPCGYTVLVTDTVGFIQDLPTTLVAAFRSTLEEVTEADLLLHIVDSSHPDYAEHERTVLQLVAELGASSIPMVTVYNKRDRQAPEFIPTTTEALVMSALSAADIERLRAFLEEAIKRQMVLYHASIPSGQGKWLARLKADTILQQWRYNEQEGTYECEGYVLPTHPLYRELQSFQ
>NZ_AP022557.1|WP_033843567.1|1429278_1429893_+|trimeric-intracellular-cation-channel-family-protein
MTWEILSIIGTIAFAISGAIVAMEEEYDLLGVYILGIVTAFGGGAVRNLLIGVPVSALWEQGSLFLVALVSMTIVYLFPKQMLPPWKRWGNFFDALGLSAFAIQGALYAAKMGHPLSAVIVAAVLTGSGGGIIRDVLAGRKPLVLHAEIYAAWAILAGIAVGLKWAESPVELYVLFIAVAALRILSYTYGWKLPRRAVGEKAGG
>NZ_AP022557.1|WP_033843566.1|1429985_1430864_-|DMT-family-transporter
MKQPVLASIYLSLAAGIWGGMYVVSKYVLDYIPPLTLVWLRYGVALIALVLIAAMKRERPPTRGRDWLMVIAIGVIGYVISISLQFVGTKWSNAHTASLITASTPAFVVLFARWLLGEALTWRKLVALVLAAAGVVVIVGLGDSGESTLAGNTALVGAAVTWALLSVLVKMASARMSVLSITTFAILVAFVGMTPMLMVERPGLTAVQWNAPVAMGVLYLGIVSTAGAFFLWNKGMEMIDAGIGSLFFLFQPLIGSLFGWLFLHERLDASFWMGGALIVAGVAVAVRSGQSA
>NZ_AP022557.1|WP_172418812.1|1431006_1432158_-|thiolase-family-protein
MMREAVIVEAVRTPVGKRNGVFRDVHPVHLAAAVLDEVVRRAGIEKGQVEDIVMGCVTPIAEQGYNIGRLAALEAGFPIEVPAVQINRMCGSGQQAIHFAAQEIRSGDMDVTIAAGVESMTKVPIFSDGNERTIPPSLHEKYEFIHQGVSAERIAKKYGLTRAEVDAYAYESHRRALAAMRARKFRAEIVPVKGLDRDGREILVTDDEGARADTSPEALAALKPVFQEDGVITAGNASQMSDGAAALLLMEREAARRFGLKPKARIVAQTVVGSDPTYMLDGVIPATRQVLKKAGLTIEDIDLIEINEVFAPVVLAWQKEIGAPLAKVNVNGGAIALGHPLGATGVKLMTSLVHELERREGRYGLLTICIGHGMATATIIERM
>NZ_AP022557.1|WP_081897289.1|1432353_1432425_-|hypothetical-protein
MRKLVEAGHLGRKTGKGFYTYTT
>NZ_AP022557.1|WP_033843564.1|1432681_1434301_-|long-chain-fatty-acid--CoA-ligase
MMKTPLTISMMLERAEVFFPKKQVISRMKGGVVRHTYKEIGERTRRLASMLKQLGVGVGDRVGTFAWNHHRHLEAYFAIPGIGAVLHTINIRLSPQHIAYIINHADDRVLLIDDDLLPAIEAVKDEIPNVRAFIIMTDADELPETALAPVYHYEKLLADGDPAFPFLKDLDEYQPAGMCYTSATTGQPKGVVYTHRSTVLHAMALGLADTLGLCERDVAMPIVPMFHVNAWGMPFAATWFGSTTVMPGPAFTPNVLAELIETERVTIVAGVPTIWLGLLQALEKGRYDVSSLTRVICGGSAAPKGVIRAFEEKYGIPFIHAYGMTETSPLVLVSRPKSYQDELSYEEKLDIRAKQGLLAPGLEMKVIGQNGPVHWDGKEMGELCLRGPWIAAEYYNDERTKETFRDGWLYTGDVVTVDEEGFVKIVDRTKDVIKSGGEWISSVDLENALMAHEAVFEAAVVAVPHPKWQERPIACVVLKEGKSVTKEELYDFLRPQFAKWWLPDDIVFLDEIPKTSVGKFLKRKLRDEMAARYADAATE
>NZ_AP022557.1|WP_033843563.1|1434304_1435378_-|CoA-transferase
MLNGIVVLDFSQYLPGPFASWRLAQLGAEVIKIEPPSGDRLRPFAGGRLFAAYNAGKKSVALDLKTDEGREQARRLAARVDVVIESFRPGVMARLGLGYDDVRRDNEGIIYCSISGFGQRSGRSLLGSHDLNYMALSGVLAQLADARGRPVHPNVTLADFIGGMAAAERVLAALFARERTGRGAYLDVSLVDGLAAMMAGHFAMEHGGGPKHGLAELAGEVVCYQLYETKDGRYMSVAALEPHFWRQFCEAIGHPEWIGAQWAPARPGEAVYDGLVALFREKTFSEWSAFAERVDACLAPVLEADEAKRLFADDQVRRLVAMQPDGVWTAAHGPDGRWDVEAPPKVNEHADLLKREE

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Crispr_ID: NZ_AP022557_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_13

1432283-1432375

Orphan

Consensus_repeat	Method
CTGTTCATGTTGTATACGTATAGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_13

>merge|NZ_AP022557|13|1432283-1432375|CRISPRCasFinder
CTGTTCATGTTGTATACGTATAGAACTCGAAGCTAACTTGAAACGGCTCTGTTTCCCCTTCAAGCGGCTGTTCATGTTGTATACGTATAGAAC

>NZ_AP022557|13|13|1432283-1432375|CRISPRCasFinder
CTGTTCATGTTGTATACGTATAGAAC	TCGAAGCTAACTTGAAACGGCTCTGTTTCCCCTTCAAGCGG
CTGTTCATGTTGTATACGTATAGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843560.1\|1438337_1439270_-\|stage-V-sporulation-protein-K	unknown	unknown	gnl\|CDD\|163057
NZ_AP022557.1\|WP_033843567.1\|1429278_1429893_+\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NZ_AP022557.1\|WP_033843562.1\|1435393_1436539_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173849
NZ_AP022557.1\|WP_033843568.1\|1427768_1429013_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|274455
NZ_AP022557.1\|WP_033023273.1\|1423051_1423357_-\|cell-division-suppressor-protein-YneA	unknown	unknown	gnl\|CDD\|184523
NZ_AP022557.1\|WP_033843569.1\|1426480_1427752_-\|methionine-gamma-lyase-family-protein	unknown	unknown	gnl\|CDD\|311036
NZ_AP022557.1\|WP_033843558.1\|1440233_1441178_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NZ_AP022557.1\|WP_033023186.1\|1439969_1440197_-\|RNA-chaperone-Hfq	unknown	unknown	gnl\|CDD\|379947
NZ_AP022557.1\|WP_033023217.1\|1421964_1422195_-\|DUF896-domain-containing-protein	unknown	unknown	gnl\|CDD\|368690
NZ_AP022557.1\|WP_033843555.1\|1445188_1446709_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_AP022557.1\|WP_033843556.1\|1443644_1444994_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NZ_AP022557.1\|WP_033023215.1\|1423508_1424132_+\|transcriptional-repressor-LexA	unknown	unknown	gnl\|CDD\|234688
NZ_AP022557.1\|WP_033843561.1\|1436563_1438138_-\|fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|235730
NZ_AP022557.1\|WP_172418812.1\|1431006_1432158_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_AP022557.1\|WP_033844861.1\|1441617_1443315_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NZ_AP022557.1\|WP_033843564.1\|1432681_1434301_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341284
NZ_AP022557.1\|WP_033023211.1\|1426002_1426404_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133380
NZ_AP022557.1\|WP_033023213.1\|1424628_1425963_-\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|273198
NZ_AP022557.1\|WP_033843563.1\|1434304_1435378_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_AP022557.1\|WP_033843566.1\|1429985_1430864_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033843560.1\|1438337_1439270_-\|stage-V-sporulation-protein-K	gnl\|CDD\|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	5.79262e-155
NZ_AP022557.1\|WP_033843567.1\|1429278_1429893_+\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	5.84197e-65
NZ_AP022557.1\|WP_033843562.1\|1435393_1436539_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	2.11104e-173
NZ_AP022557.1\|WP_033843568.1\|1427768_1429013_-\|GTPase-HflX	gnl\|CDD\|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	0
NZ_AP022557.1\|WP_033023273.1\|1423051_1423357_-\|cell-division-suppressor-protein-YneA	gnl\|CDD\|184523	PRK14125, PRK14125, cell division suppressor protein YneA; Provisional.	5.91263e-47
NZ_AP022557.1\|WP_033843569.1\|1426480_1427752_-\|methionine-gamma-lyase-family-protein	gnl\|CDD\|311036	pfam06838, Met_gamma_lyase, Methionine gamma-lyase. This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.	0
NZ_AP022557.1\|WP_033843558.1\|1440233_1441178_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	1.52138e-168
NZ_AP022557.1\|WP_033023186.1\|1439969_1440197_-\|RNA-chaperone-Hfq	gnl\|CDD\|379947	pfam17209, Hfq, Hfq protein.	6.13675e-39
NZ_AP022557.1\|WP_033023217.1\|1421964_1422195_-\|DUF896-domain-containing-protein	gnl\|CDD\|368690	pfam05979, DUF896, Bacterial protein of unknown function (DUF896). In B. subtilis, one small SOS response operon under the control of LexA, the yneA operon, is comprised of three genes: yneA, yneB, and ynzC. This family consists of several short, hypothetical bacterial proteins of unknown function. These proteins are mainly found in gram-positive firmicutes. Structures show that the N-terminus is composed of two alpha helices forming a helix-loop-helix motif. The structure of ynzC from B. subtilis forms a trimeric complex. Structural modelling suggests this domain may bind nucleic acids. This family is also known as UPF0291.	7.16426e-30
NZ_AP022557.1\|WP_033843555.1\|1445188_1446709_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NZ_AP022557.1\|WP_033843556.1\|1443644_1444994_-\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.34741e-53
NZ_AP022557.1\|WP_033023215.1\|1423508_1424132_+\|transcriptional-repressor-LexA	gnl\|CDD\|234688	PRK00215, PRK00215, transcriptional repressor LexA.	1.85e-116
NZ_AP022557.1\|WP_033843561.1\|1436563_1438138_-\|fatty-acid--CoA-ligase	gnl\|CDD\|235730	PRK06187, PRK06187, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_AP022557.1\|WP_172418812.1\|1431006_1432158_-\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	0
NZ_AP022557.1\|WP_033844861.1\|1441617_1443315_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	2.28167e-58
NZ_AP022557.1\|WP_033843564.1\|1432681_1434301_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341284	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles. This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.	0
NZ_AP022557.1\|WP_033023211.1\|1426002_1426404_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133380	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators. Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	4.43812e-25
NZ_AP022557.1\|WP_033023213.1\|1424628_1425963_-\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_AP022557.1\|WP_033843563.1\|1434304_1435378_-\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	2.80827e-96
NZ_AP022557.1\|WP_033843566.1\|1429985_1430864_-\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.4365e-22

>NZ_AP022557.1|WP_172418812.1|1431006_1432158_-|thiolase-family-protein
MMREAVIVEAVRTPVGKRNGVFRDVHPVHLAAAVLDEVVRRAGIEKGQVEDIVMGCVTPIAEQGYNIGRLAALEAGFPIEVPAVQINRMCGSGQQAIHFAAQEIRSGDMDVTIAAGVESMTKVPIFSDGNERTIPPSLHEKYEFIHQGVSAERIAKKYGLTRAEVDAYAYESHRRALAAMRARKFRAEIVPVKGLDRDGREILVTDDEGARADTSPEALAALKPVFQEDGVITAGNASQMSDGAAALLLMEREAARRFGLKPKARIVAQTVVGSDPTYMLDGVIPATRQVLKKAGLTIEDIDLIEINEVFAPVVLAWQKEIGAPLAKVNVNGGAIALGHPLGATGVKLMTSLVHELERREGRYGLLTICIGHGMATATIIERM
>NZ_AP022557.1|WP_033843566.1|1429985_1430864_-|DMT-family-transporter
MKQPVLASIYLSLAAGIWGGMYVVSKYVLDYIPPLTLVWLRYGVALIALVLIAAMKRERPPTRGRDWLMVIAIGVIGYVISISLQFVGTKWSNAHTASLITASTPAFVVLFARWLLGEALTWRKLVALVLAAAGVVVIVGLGDSGESTLAGNTALVGAAVTWALLSVLVKMASARMSVLSITTFAILVAFVGMTPMLMVERPGLTAVQWNAPVAMGVLYLGIVSTAGAFFLWNKGMEMIDAGIGSLFFLFQPLIGSLFGWLFLHERLDASFWMGGALIVAGVAVAVRSGQSA
>NZ_AP022557.1|WP_033843567.1|1429278_1429893_+|trimeric-intracellular-cation-channel-family-protein
MTWEILSIIGTIAFAISGAIVAMEEEYDLLGVYILGIVTAFGGGAVRNLLIGVPVSALWEQGSLFLVALVSMTIVYLFPKQMLPPWKRWGNFFDALGLSAFAIQGALYAAKMGHPLSAVIVAAVLTGSGGGIIRDVLAGRKPLVLHAEIYAAWAILAGIAVGLKWAESPVELYVLFIAVAALRILSYTYGWKLPRRAVGEKAGG
>NZ_AP022557.1|WP_033843568.1|1427768_1429013_-|GTPase-HflX
MSREQAIIVGCQLHGIDDERFRYSMEELAALVATANGEVVAELTQKREAPHPATYIGKGKTEELAALVKQLTPDLVIFNSELSPSQARNLTNMLGEVKVIDRTQLILDIFARRARSKEGKLQVELAQLEYLLPRLGGQGAALSRLGGGIGTRGPGETKLETDRRHIRRRIDDIKAELRRIAEHRERYRGRRQKNHAFQVALVGYTNAGKSTIFNRLTAADSFEENLLFATLDPLTRQCVLPCGYTVLVTDTVGFIQDLPTTLVAAFRSTLEEVTEADLLLHIVDSSHPDYAEHERTVLQLVAELGASSIPMVTVYNKRDRQAPEFIPTTTEALVMSALSAADIERLRAFLEEAIKRQMVLYHASIPSGQGKWLARLKADTILQQWRYNEQEGTYECEGYVLPTHPLYRELQSFQ
>NZ_AP022557.1|WP_033843569.1|1426480_1427752_-|methionine-gamma-lyase-family-protein
MFWTTWKHGETIAALIEEVEAQIAPIHRSIERLVDGNQHRVLDSFRRHQVSDGHFIPTTGYGYDDVGRDTLDRIYADVFGAEAGLVRPQIISGTHAIAIALFGVLRPGDELLYITGAPYDTLEEIVGVRGRGVGSLNEFGIRYRSVPLTADGAVDFPAVREAIHERTKMIGIQRSRGYATRPSFTVDEIAKMIAFVKAIKPDVVVFVDNCYGEFVEEKEPCHVGADLMAGSLIKNPGGGLAKTGGYIVGRHQYVEACAYRMTSPGIGAEVGPSLYSLLEMYQGFFLAPHVVGQALKGAVFTAALLERVGLETSPSWNAKRTDLVQSVRFNDPEQMVAFCQAIQAASPVNAHFTPYPSDMPGYEDQVIMAAGTFVQGASIELTADGPLRPPYVAYVQGGLTYSHVKIAVCSAVHRLLEQQLICL
>NZ_AP022557.1|WP_033023211.1|1426002_1426404_-|MerR-family-transcriptional-regulator
MSSQIRRSMPLFPIGIVMQLTDLSARQIRYYEEHGLVTPARTEGNRRLFSLNDIDRLLEIKDLIDQGVNLAGIKRIFAARQEGRHEQPEKVDKAGKPKLSDEELREILRTELLQAGRFQRASLRQGDLARFFH
>NZ_AP022557.1|WP_033023213.1|1424628_1425963_-|type-I-glutamate--ammonia-ligase
MAKYTREDIMRIVKEENVKYIRLQFTDILGTIKNVEIPISQLEKALNNKMMFDGSSIEGFVRIEESDMYLYPDLDTFVIFPWTAEKGKVARFICDIYNADGTPFEGCPRYNLKRVLKEMEALGFTAFNLGAEPEFFLFKLDEKGHPTMELNDRGGYFDLAPTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAHAIKACDDIQTFKLVVKTIARKHGLHATFMPKPIFGINGSGMHCNLSLFRNGENAFFDPNGELQLSETARQFIAGVLKHAPNFTAVTNPTVNSYKRLVPGYEAPCYVAWSARNRSPLIRIPASRGMSTRIEVRSVDPSANPYLAMAVLLAAGLDGIRNKLTPPAPVDRNIYVMTKEERLEEGIVDLPATLIEALENLKSDEVIVQALGKHLFEHFVEAKEIEWDMYRTTVHQWELDQYMELY
>NZ_AP022557.1|WP_033023215.1|1423508_1424132_+|transcriptional-repressor-LexA
MTKLSKRQQQILEFIKQEVKTKGYPPSVREIGEAVGLASSSTVHGHLARLESKGYIRRDPTKPRAIEILDNDGGKEKEGEDIVSVPIIGKVTAGQPITAVENIEDYFPLPKRLAAGEEQLFMLEVMGDSMIEAGILDGDYVIVRQQSSAQNGDIVVAMTEDNEATVKRFFKEKDHIRLQPENAHLEPIIVRDCTILGKVIGVYRLIG
>NZ_AP022557.1|WP_033023273.1|1423051_1423357_-|cell-division-suppressor-protein-YneA
MKKTFVHYLVFSVLMTLFTAAFIYAGSPVDKQEYVTVTVASGDTLWGLAKQYEQEHGLSPDEFIRWVVEVNHLRSSRLTAGEQIVIPVLKSKRGGSLAANQ
>NZ_AP022557.1|WP_033023217.1|1421964_1422195_-|DUF896-domain-containing-protein
MLAKQKLDRINELAKKAKTSGLTAEETIEQAKLRREYIQAFRKAMTDMLHTVTVIDPNGNDVTPKKLKESQRRRLH
>NZ_AP022557.1|WP_033843564.1|1432681_1434301_-|long-chain-fatty-acid--CoA-ligase
MMKTPLTISMMLERAEVFFPKKQVISRMKGGVVRHTYKEIGERTRRLASMLKQLGVGVGDRVGTFAWNHHRHLEAYFAIPGIGAVLHTINIRLSPQHIAYIINHADDRVLLIDDDLLPAIEAVKDEIPNVRAFIIMTDADELPETALAPVYHYEKLLADGDPAFPFLKDLDEYQPAGMCYTSATTGQPKGVVYTHRSTVLHAMALGLADTLGLCERDVAMPIVPMFHVNAWGMPFAATWFGSTTVMPGPAFTPNVLAELIETERVTIVAGVPTIWLGLLQALEKGRYDVSSLTRVICGGSAAPKGVIRAFEEKYGIPFIHAYGMTETSPLVLVSRPKSYQDELSYEEKLDIRAKQGLLAPGLEMKVIGQNGPVHWDGKEMGELCLRGPWIAAEYYNDERTKETFRDGWLYTGDVVTVDEEGFVKIVDRTKDVIKSGGEWISSVDLENALMAHEAVFEAAVVAVPHPKWQERPIACVVLKEGKSVTKEELYDFLRPQFAKWWLPDDIVFLDEIPKTSVGKFLKRKLRDEMAARYADAATE
>NZ_AP022557.1|WP_033843563.1|1434304_1435378_-|CoA-transferase
MLNGIVVLDFSQYLPGPFASWRLAQLGAEVIKIEPPSGDRLRPFAGGRLFAAYNAGKKSVALDLKTDEGREQARRLAARVDVVIESFRPGVMARLGLGYDDVRRDNEGIIYCSISGFGQRSGRSLLGSHDLNYMALSGVLAQLADARGRPVHPNVTLADFIGGMAAAERVLAALFARERTGRGAYLDVSLVDGLAAMMAGHFAMEHGGGPKHGLAELAGEVVCYQLYETKDGRYMSVAALEPHFWRQFCEAIGHPEWIGAQWAPARPGEAVYDGLVALFREKTFSEWSAFAERVDACLAPVLEADEAKRLFADDQVRRLVAMQPDGVWTAAHGPDGRWDVEAPPKVNEHADLLKREE
>NZ_AP022557.1|WP_033843562.1|1435393_1436539_-|acyl-CoA-dehydrogenase-family-protein
MAARYLREEHQIFRDAFRKFLEKEAYPYYDEWERRGIIPRSFWAKMGENGFLCPWVDEKYGGLNADFAYSVVINEELEKVGSSLVGIGLHNDIVTPYIASYGTEEQKQKWLPKCVSGELITAIAMTEPGAGSDLANISTTAVKDGDAYIVNGQKTFITNGIHADLVIVACKTDPHAKPPHRGISLLVVERDTPGFTRGRKLEKVGLHAQDTAELFFQDAKVPASNLLGEEGKGFYYLMEKLQQERLVVAIAAQTAAEVMVSLTKQYVKQRTAFGKRVSEFQTVQFRLAEMATEIALGRTFVDRVIEEHMAGKRIVTEVSMAKWWITEMAKRVAAEAMQLHGGYGYMEEYEIARRYRDIPVSAIYAGTNEMMKTIIARELDL
>NZ_AP022557.1|WP_033843561.1|1436563_1438138_-|fatty-acid--CoA-ligase
MYMTIGELFSQTVRKFPNREAVVEVATGRRYTYAEWERDVNRWANAFQEAGVRKGDRVSTVLYNTFELASALFACAKIGAVFNPINFRLKAEEIAYILTDAGPKLVLLERAVEPQLAAIHHRFPHVSFWSIDHDPPPFAKSAHEQAARASAEAPRVPVEESDLYAIMYTSGTTGRPKGVMHRHRDMIEQSVLCHGVMRIRETDRGLAAAPLFHCAELHCCLLPRVHAGAASVILHHFDAKLVLETIERERITLLFGAPTMWNMILQENVSDYDLSSLRLGLYGAAPMAPALVRQCQERLGIELIQAYGMTEMGPAVTFLLEDEQLKKPGSAGRACLNHEIRVVRAREDGPSDPDDVLPPYEVGEIVMRGPCMMVGYYKREEATEQALYKGWYHSGDLGYVDEDGYLYVADRVDDMVISGGENVYPREVEDVLYEHPKVLDVAVLGEPDELWGEKVVAFIVKKEDSLTAEELEQFCQTSDRLAPYKRPRAYYFIDALPRNASGKIQKFLLREQLKKQAAGGTEKK
>NZ_AP022557.1|WP_033843560.1|1438337_1439270_-|stage-V-sporulation-protein-K
MSELTMNKAKGQINIVLNSKTVNHLIKEEPSDWMDSEEHQALRNIQRELDQLIGLEHVKKMIKEIYAWLYINRLRKENGLKSSRQALHMIFKGNPGTGKTTVARLLGKLFYEMNVLSKGHFIEAERADLVGEYIGHTANKTRDLIKKARGGILFIDEAYSLARGGEKDFGKEAIDTLVKGMEDFCDDLVVILAGYPKEMDYFLSLNPGLPSRFPLTIEFPDYTVEELVQIAKQMLREREYEMTPEAERKLYIHLEGTLEATGRLKFSNGRYVRNLIEKAIRKQAVRLLHEGRYDKKELMTIRDRDLVIQA
>NZ_AP022557.1|WP_033023186.1|1439969_1440197_-|RNA-chaperone-Hfq
MKNVINIQDQFLNQLRKEGIQVTVFLLNGFQLRGYIKGFDNFTVLLEVQGKQQLIYKHAISTFAPERNIHFDAEQ
>NZ_AP022557.1|WP_033843558.1|1440233_1441178_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MGGKVVVIVGPTAVGKTKLGIALAKKLDGEIISGDSMQIYKGMDIGTAKVKPDEMEGIPHHLIDIKEPCEPFSVVEFQRLARTLIAEISARGRLPIIVGGTGLYIQAAIYDYQFSDAPSDEAYRRTLKQLAAEQGPEALHRRLSAVDPESAARIHPHNIRRVIRALEVHHCTGKPFSAWQRGERRLLYETAIIGLTAERDVLYRRINERVDAMIAAGLIEEAKSLYDRGFRDCQAVQAIGYKELYDYFDGRVSLEEAIEQLKQHSRRYAKRQLTWFRNQMPVTWFDMTDFAAFPARTKEIFHYIAGKLQLEANI
>NZ_AP022557.1|WP_033844861.1|1441617_1443315_-|methyl-accepting-chemotaxis-protein
MSMKLTVRKKLFAGFGLVYVLIALLVGFAYYENSVLDRTYTDVIEKRVPKLVNTKELEVLVRREVGSMRGYLLTGDATSKENFEKAHKAYKQTSEKLAASSTQEATKQRLAELDLLEQQFYELGQKTFELKDQNKTEQYTALIVTTGRDLTTQFEQKIDQLAALHEREMKQANRDASASAAAVLHLVLIVGVLTIAMGAAVSYYISRSLSRPLLALTDAAKRIAAGDLREANISVRNRDEIGQLAAAFEQMANNLRQVIQQVAQNAEQVAAASEQLAASAEQTSKATEQIAMTVQSVASGVDQQMQSVEETSSVINAMSEQIGKVSARAQNVVAIAADTSKRAADGGETIDAGVAQMDTVNRTVEQLAEVVKGLGHRSEQIGSIIEAIRTIAAQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAEQSAASAQQIAELIAAIQEETAHAVASMESVVNEVASGTNVIRTSGETFAQIRAAVDEVAAQIRDVSTAVGEMAASSEQIVRSVRLVADVAESTSASAQEVSAATEEQLASMEEISASSAALARMADDLQAIVRKFSL
>NZ_AP022557.1|WP_033843556.1|1443644_1444994_-|MFS-transporter
MNSRLSVMVSIVMAMLVASMDTTIMNTTMPIIANELGEFSLYAWAFASYMITTTVLSPIAGRLSDLFGRKKVFSFGIMFFLIGSLLCGLSQSMVQLVVFRALQGVGAGFMMPFPAIIAGDLFPVEKRGKIQAFFTAMWGISAVLAPLLGSLFVEYATWRWIFYVNIPICLLSLLTLLPYQEVYEPKRASVDYMGAALFAAAISLLLLVTVVERGQWWYGAVGALLLVAFYYFEKRQPSPLVPLSLVHHRTLKWMNINGFVSCVALFGTSSYIPLFLQNVAHLSVFMSGVALLGSSVGWMIAAVPAGKWILRYGYRLLLIIGNVLLVVSGLLLALLNESHGFWYVFFIMFLQGLSFGLTSTVGIIGSQQLADVHEKGIATSFFMFCRNIGTAIGVTVMGALLAQAPTFITGIHHLFLFGFIGSIVALATSFLIRDQAEAGGNTRKPEETA
>NZ_AP022557.1|WP_033843555.1|1445188_1446709_+|BCCT-family-transporter
MKKTTIVFSISIVIAIAFTIWGMIPESLWPRYNLNAVSSAVHTFLIDKFSWFYLLSASLFLAFCLFLIFSRYGNIRLGRDEEKPEYSYMTWFAMLFSAGMGIGLVFWGVAEPVSHYYTPPTGEGATTEAARLAMRYSFFHWGLHPWAIYGVLALALAYFQFRKRDAGVVSRTLRPLFGTRIEGGLGVAIDTLAVYATVFGIATSLGLGAIQISGGLHQLFPRIPNSFSTQLLIIVVVTVLFMLSAQTGLNKGIKWLSNLNIALALLLMVFMLFAGPTNFIMDVFTSTIGTYLQNLPSMSFRLNPFEQNDWPKVWTIFYWAWWIAWAPFVGTFIARISRGRTIREFMIGVLAVPTIFSALWFSVFGGSALYLEQFQHAGIGKVMNEKGIETALFFTFEHFPLATLLSGIAILLICTFFVTSADSATFVLGMQTTNGSLNPPNSVKFVWGIVQSAIAAILLFVGGLESLQTASIIAAFPFAIIMILIVLALIRSFQQETARKAQKPIK

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Crispr_ID: NZ_AP022557_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_14

1667300-1667396

Orphan

Consensus_repeat	Method
CTTGCATGCTTCATACTAAATGCATGGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_14

>merge|NZ_AP022557|14|1667300-1667396|CRISPRCasFinder
CTTGCATGCTTCATACTAAATGCATGGAGCGCCTCTTGCGAAAGGGGAGGACGGGCGTTGGAAGTCGCTTGCATGCTTCATACTAAATGCATGGAGC

>NZ_AP022557|14|14|1667300-1667396|CRISPRCasFinder
CTTGCATGCTTCATACTAAATGCATGGAGC	GCCTCTTGCGAAAGGGGAGGACGGGCGTTGGAAGTCG
CTTGCATGCTTCATACTAAATGCATGGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843479.1\|1657179_1659387_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223839
NZ_AP022557.1\|WP_033844843.1\|1674525_1674972_-\|YlbF-family-regulator	unknown	unknown	gnl\|CDD\|226204
NZ_AP022557.1\|WP_033843466.1\|1672467_1673064_-\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|367574
NZ_AP022557.1\|WP_033843476.1\|1663173_1663560_-\|DUF3397-domain-containing-protein	unknown	unknown	gnl\|CDD\|378748
NZ_AP022557.1\|WP_011230605.1\|1666096_1666270_-\|50S-ribosomal-protein-L32	unknown	unknown	gnl\|CDD\|237038
NZ_AP022557.1\|WP_033843471.1\|1667488_1668709_+\|nucleotidyltransferase	unknown	unknown	gnl\|CDD\|237464
NZ_AP022557.1\|WP_033843470.1\|1668681_1669701_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|226011
NZ_AP022557.1\|WP_033843469.1\|1669697_1670486_-\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132866
NZ_AP022557.1\|WP_033843474.1\|1664545_1665121_-\|RsfA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|274342
NZ_AP022557.1\|WP_033843465.1\|1673069_1673258_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843477.1\|1661097_1662726_-\|bacillithiol-biosynthesis-cysteine-adding-enzyme-BshC	unknown	unknown	gnl\|CDD\|274913
NZ_AP022557.1\|WP_172418591.1\|1670571_1671852_+\|sporulation-integral-membrane-protein-YlbJ	unknown	unknown	gnl\|CDD\|274333
NZ_AP022557.1\|WP_033843467.1\|1671995_1672502_-\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234674
NZ_AP022557.1\|WP_033843472.1\|1666415_1666958_-\|DUF177-domain-containing-protein	unknown	unknown	gnl\|CDD\|224317
NZ_AP022557.1\|WP_033022165.1\|1674237_1674507_-\|YlbG-family-protein	unknown	unknown	gnl\|CDD\|179491
NZ_AP022557.1\|WP_033843473.1\|1665194_1665950_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_AP022557.1\|WP_033022170.1\|1673442_1673832_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843478.1\|1659886_1660819_-\|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH	unknown	unknown	gnl\|CDD\|234597
NZ_AP022557.1\|WP_033844845.1\|1659393_1659750_-\|cell-division-protein-FtsL	unknown	unknown	gnl\|CDD\|227176
NZ_AP022557.1\|WP_051962664.1\|1663552_1664473_-\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|235821

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033843479.1\|1657179_1659387_-\|penicillin-binding-protein	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	1.98778e-151
NZ_AP022557.1\|WP_033844843.1\|1674525_1674972_-\|YlbF-family-regulator	gnl\|CDD\|226204	COG3679, COG3679, Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms].	7.71262e-36
NZ_AP022557.1\|WP_033843466.1\|1672467_1673064_-\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|367574	pfam03602, Cons_hypoth95, Conserved hypothetical protein 95.	1.77754e-74
NZ_AP022557.1\|WP_033843476.1\|1663173_1663560_-\|DUF3397-domain-containing-protein	gnl\|CDD\|378748	pfam11877, DUF3397, Protein of unknown function (DUF3397). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 114 to 128 amino acids in length.	1.26653e-15
NZ_AP022557.1\|WP_011230605.1\|1666096_1666270_-\|50S-ribosomal-protein-L32	gnl\|CDD\|237038	PRK12286, rpmF, 50S ribosomal protein L32; Reviewed.	5.46276e-28
NZ_AP022557.1\|WP_033843471.1\|1667488_1668709_+\|nucleotidyltransferase	gnl\|CDD\|237464	PRK13670, PRK13670, nucleotidyltransferase.	0
NZ_AP022557.1\|WP_033843470.1\|1668681_1669701_-\|PDZ-domain-containing-protein	gnl\|CDD\|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	1.74639e-127
NZ_AP022557.1\|WP_033843469.1\|1669697_1670486_-\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132866	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6. Bacterial patatin-like phospholipase domain containing protein 6. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This group includes YCHK and rssA from Escherichia coli as well as Ylbk from Bacillus amyloliquefaciens.	2.11392e-72
NZ_AP022557.1\|WP_033843474.1\|1664545_1665121_-\|RsfA-family-transcriptional-regulator	gnl\|CDD\|274342	TIGR02894, DNA_bind_RsfA, transcription factor, RsfA family. In a subset of endospore-forming members of the Firmcutes, members of this protein family are found, several to a genome. Two very strongly conserved sequences regions are separated by a highly variable linker region. Much of the linker region was excised from the seed alignment for this model. A characterized member is the prespore-specific transcription RsfA from Bacillus subtilis, previously called YwfN, which is controlled by sigma factor F and seems to fine-tune expression of some genes in the sigma-F regulon. A paralog in Bacillus subtilis is designated YlbO. [Regulatory functions, DNA interactions, Cellular processes, Sporulation and germination].	3.60189e-48
NZ_AP022557.1\|WP_033022165.1\|1674237_1674507_-\|YlbG-family-protein	gnl\|CDD\|179491	PRK02886, PRK02886, hypothetical protein; Provisional.	3.25916e-50
NZ_AP022557.1\|WP_033843477.1\|1661097_1662726_-\|bacillithiol-biosynthesis-cysteine-adding-enzyme-BshC	gnl\|CDD\|274913	TIGR03998, thiol_BshC, bacillithiol biosynthesis cysteine-adding enzyme BshC. Members of this protein family are BshC, an enzyme required for bacillithiol biosynthesis and described as a cysteine-adding enzyme. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	0
NZ_AP022557.1\|WP_172418591.1\|1670571_1671852_+\|sporulation-integral-membrane-protein-YlbJ	gnl\|CDD\|274333	TIGR02871, conserved_hypothetical_protein, sporulation integral membrane protein YlbJ. Members of this protein family are found exclusively in Firmicutes (low-GC Gram-positive bacterial) and are known from studies in Bacillus subtilis to be part of the sigma-E regulon. Mutation leads to a sporulation defect, confirming that members of this protein family, YlbJ, are sporulation proteins. This protein appears to be universal among endospore-forming bacteria, but is encoded by a pair ORFs distant from eash other in Symbiobacterium thermophilum IAM14863. [Cellular processes, Sporulation and germination].	5.10812e-150
NZ_AP022557.1\|WP_033843467.1\|1671995_1672502_-\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	2.72493e-103
NZ_AP022557.1\|WP_033843472.1\|1666415_1666958_-\|DUF177-domain-containing-protein	gnl\|CDD\|224317	COG1399, COG1399, Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only].	5.70194e-29
NZ_AP022557.1\|WP_033843473.1\|1665194_1665950_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	2.47854e-56
NZ_AP022557.1\|WP_033843478.1\|1659886_1660819_-\|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH	gnl\|CDD\|234597	PRK00050, PRK00050, 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH.	0
NZ_AP022557.1\|WP_033844845.1\|1659393_1659750_-\|cell-division-protein-FtsL	gnl\|CDD\|227176	COG4839, FtsL, Protein required for the initiation of cell division [Cell division and chromosome partitioning].	4.27371e-21
NZ_AP022557.1\|WP_051962664.1\|1663552_1664473_-\|2-dehydropantoate-2-reductase	gnl\|CDD\|235821	PRK06522, PRK06522, 2-dehydropantoate 2-reductase; Reviewed.	1.62071e-92

>NZ_AP022557.1|WP_033843472.1|1666415_1666958_-|DUF177-domain-containing-protein
MKWTVQQLRRFQHKEMVIDETIDVSDLKQIDTLIRDISPVRVQGKADVASTKFTFHLTLSGTMVLPCSRTLVDVHYPFSIETTETFFAEGGGLAETDDDTHVLTGDTVDLHPIIRELILLEIPLQLIADSPAVDGAPQHGEGWDVLTEDEWEKVVQEREANKVDPRLAGLAKFFEEKREK
>NZ_AP022557.1|WP_011230605.1|1666096_1666270_-|50S-ribosomal-protein-L32
MAVPFRRTSKTRKRLRRTHFKLQVPGMVQCPNCGEWKLAHRVCKACGTYKGRDVVNK
>NZ_AP022557.1|WP_033843473.1|1665194_1665950_-|enoyl-CoA-hydratase/isomerase-family-protein
MEAKMEYEAGVGLFTICRPEKRNAINFAVMEALEEAMKRAAADEHVKVFAITGAGGEAFCSGGDLHEFGHLRGAEAKQMLTRMGELLYKLLTFPKPTVALVNGTAIGGGCELATACDIRLVKEGSRIGFVQGRLGITTGWGGASMLFAKLPYGQALDVLLRAELMTAEEMKARGWTDAIVPAESWREQWRQRLAVYTERSLAVLQAYKATAGEKWRTAWFREQFFTEIDRCAELWGSREHEQALRAFLHKK
>NZ_AP022557.1|WP_033843474.1|1664545_1665121_-|RsfA-family-transcriptional-regulator
MTGIRQDAWTKEEDELLAKVVLQYIREGNTQLEAFAEVGRRLSRTAAACGFRWNSCVRKQYKEDIELAKQERKRRKKEVAAIKESGGWAKVEAEGKQHLSWPDVLAFLQAEEQKAREARRAADENRALKNDMEQLQQMVTKLQMEKEALEKQLATVQEEYKTLLAIMERARQMVADHEKPEPNEADGAGES
>NZ_AP022557.1|WP_051962664.1|1663552_1664473_-|2-dehydropantoate-2-reductase
MSRKRGRGSLKIGIVGGGAVGLLLAAYLGRHHEVTMYTRRLAQAKQLAEQGVALEKDGETTTVAVRARPFADAELDEPLVFVAVKQYDLDAIWARADAFRRVRTLVFVQNGMGHLDSLPLLVGQTILAGVVEHGAWKRDDRTVVHTGVGKLTLAVRFGSIGDARELQSDDPHFPIEWVDDWKRMLVDKLVVNAVINPLTALLQVNNGALLEVAPYREMMAQLFDEVRQALALADEQRAWERIVHICRKTADNYSSMYMDLAHGRRTEIDAILGYVLQQGEARGVALPLIRFLFCAIKGKEGREEDG
>NZ_AP022557.1|WP_033843476.1|1663173_1663560_-|DUF3397-domain-containing-protein
MDEWLASALATFITAPLLLFLLVYVGARLFGRRKRSSFYAAVNAATVFFIAAVYFLLAVVFHRSYLVPLLLFLFVLHALIALGYWRKQGDFRLRAVFRLFWRASFLIFASLYAGLMVYGIVVRIAASL
>NZ_AP022557.1|WP_033843477.1|1661097_1662726_-|bacillithiol-biosynthesis-cysteine-adding-enzyme-BshC
MEVRDISLPAATKLAADYITGAFPAERGFAYARVDDEAFRRRLSYLQEKTYARRALADYLRVYHRRLAAGAKTMGNIERLSDERSVVVVGGQQAGLLTGPLYTIYKIITIIRLAKEQEEKLGVPVVPLFWIAGEDHDIAEINHVYVVEGGEVKKAVYPHKVNDRRMAADLPLDRRLAEEWVERVVKTYGETDVTNELLSFLFSCLDGAATFVDFFAAIVLRLFADEGLVVLNAGDAAVRPLERRFFAELVNRHRDVTSAVLAQQEALRALGYAPLIEIGPDAANLFYYDGHERSLLHYDEQTGRFRTKAGNVAWTKEELLALAETKPACFSNNVVTRPLMQEYLLPTLAFVAGPGEIAYWAELKEAFPLFGMEMPPVVPRLQATIVSRSLQTDLADLGLEAADVLRGQLDVVKQQWLKRTAEAPLSSAFAKAKAEVEAAHRPLRELGMAIDRGLEGLMAKNAAIIQAQIEFLQQALERALLRKHETQWRKFWRVETALRPHGAPQERIWNVFYYVNRYGFDFVEKLLSIPAPENGMHKIVYI
>NZ_AP022557.1|WP_033843478.1|1659886_1660819_-|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH
MFRHTTVLLKEAVDGLNVRPDGVYVDCTLGGGGHSEYLLSLLSERGKLFAFDQDEAAIAHARKRLARYGERVQFVHRNFRFLREELSAFGVHCVDGVLFDLGVSSPQLDEPERGFSYQHDAPLDMRMDRTQSLTAAEIVNRWPYEELVRIFFRYGEEKFSKQVARKIEEARRQQPIETTGELVEVIKAAIPAPARRSGGHPAKRIFQALRIAVNDELEAFREALEQAIELLAPGGRVSVITFHSLEDRICKETFKKASERPPLPPGLPVLPEEGRPVLKIITKKPIVPSENELEQNHRARSAKLRIAEKR
>NZ_AP022557.1|WP_033844845.1|1659393_1659750_-|cell-division-protein-FtsL
MNDAAVKVVREQGRPAASPSRAPRRKRRFRLSLAEKLLFVSFFLFVVYAAVHIVANQVRLYELNRHVQQLEATIGEQKKANNDLYVEVQRLSAYERILQKAKELGLSLDENRVKVVQE
>NZ_AP022557.1|WP_033843479.1|1657179_1659387_-|penicillin-binding-protein
METKKHRNTHRGAWLLFCLFGLAFSLLFARFIQLGWTGKAEGHPVAEIAEQQRKQTRTLEAKRGTIFDRNDGILAQDVPSYTLVAVLDPNMTTDPNHPRHVVDPEKTAKKLAPLLGMDVEKMKRILTKKAKQVEFGSYGRNISFELKRKIEALDLPGIAFIRDTTRFYPNGTFASYVVGYAQKNEHNDTVGQMGIEKQLDRYLREKDGYVSFDGDANGFRLPGGKEHIVKPNNGANVYLTIDEKIQTFLEDAMNGVEKQYRPKKMIAIVADPKTGKILAMATRPSFDPNKRNITNFFNDAISYPYEPGSTMKVFTLAAAINEGVYNGNETFHSGSYRVGPNIVRDHNDVGWGTITFNEGVQRSSNVAFSILVKEKLGEDRFLQYLHRFHFDQKTGIDLPNEAVGQIRYRYPIERITTGFGQGTSVTPIQQIQAATAIANDGKMMKPYVIEKVVDPDSGKVLLDHEPTVVGEPITAETARKVRDILETVVTSEHGTGRPYQIEGYRVAGKTGTAQIPSAAGGYLTGRENYIFSFLGMAPADDPKLLMYVAVQQPHLDVTETGAAPVSQIFTTVMKSSLQYLHIQPVEEKRTEEKKAQRPLDSFIGQPAELAAKQLKESGYVPVVIGRGRSVEDQLPQAGEDVLVGERVVLKTDGTAAMPDLRGFSLRDAMKVARVLGLRPSTKGSGYVISQSIRPGAEVRKGDYLIVELAPPRQWEEAAARKAKEAAERKDDGPHE
>NZ_AP022557.1|WP_033843471.1|1667488_1668709_+|nucleotidyltransferase
MKAVGVIVEYNPFHNGHLHHLQETRRKTNADCLIAVMSGNFLQRGEPAIVSKWARTKMALASGIDIVIELPYAFAVQAAERFASGAVRLLAAIGCRELCFGSESGDIAAFLSAADTWSEQQEPFDSLVRAELARGQSFPRAAAAAWQALGAAPLDLSKPNNVLGFAYVKAIRQHALPMTPHTIPRRAAGYHDESASHPSIASATSVRKILRQTGQLEAVAAYVPAAALDQLRQYQETYGRLHDWEMYFPLLKYRLLTATEADLRRIAGVEEGIEHRLKQHIAAAETFAAFIAAVKTKRYTWTRLQRLCTHVLTHFTKEAQSEAADPTYIRLLGMSETGRRYLQQVKKQLALPLVAKAAKLNGDPLYEQEKRAAAAYAAAFPEPLASRAFREEYATAPIYFSGMERK
>NZ_AP022557.1|WP_033843470.1|1668681_1669701_-|PDZ-domain-containing-protein
MKRRTYIVAFVLGVVLTFLFIFIKLPYYVTMPGSAQSLRPLVHVEHGDRDAGTLMLTTVRMGRANVASYLLAHIRPFYELYPAEEIKQEGESDKDYTLRQLELMEQAKEAAIIVAYRQAGKPVSYQPRGAYVMSVLSDMPAAGRLKTGDLIVALDGKPLATSEQMVSYLRGKKAGDRVRVTFIRGGKRREAEIALRPFPDHPDQAGLGVMPVTEYDIRTDPPVEIDSEQIGGPSAGLMFSLEIYNQLVPEDITKGHKIAGTGTIDLNGNVGPIGGVSQKVVAADREGAEVFFAPNEHGAPASNYREALRTAKQIGTKMKIVPVDTFDDAIRYLRSMPEK
>NZ_AP022557.1|WP_033843469.1|1669697_1670486_-|patatin-like-phospholipase-family-protein
MPPKIGVALGSGGARGFAHLGVLNVLEDEQIPISYLAGSSIGALVAVLYASGHGLHRLYRLAQSFRRNDFLDWTVPKMGLIAGERITQFIRLLTKGKRLEELSPPVAVVATDLRTGEKVVFREGEAARAVRASISIPGIFVPAEMNGRLLVDGGVVDRVPVSVVRAMGADLVIAVDVAPLNTNAEITSIADVIWKSLDILQAELVVHRQLASDVMIRPRVESYSSRAFTDIKEIIARGEEEARKQIAAIRRAMEQWKEPSSR
>NZ_AP022557.1|WP_172418591.1|1670571_1671852_+|sporulation-integral-membrane-protein-YlbJ
MRLYRAKLHGKKGGRPLKRNWGTKGKTALLASAATLFAFALISYPKQSLEASIRGLTMWWEVVFPSLLPFFIVSELLISFGVVNFLGVLLEPLMRPLFRVPGVGGFAWAMGMASGYPSGAKLTARLYQEKQLSTIEAERLSSFTNSSNPLFIFGAVSAGFFHNPQLGFVLAASHYLGNITVGLIMRFHGIRKERGQPKSRRRPFSLPYALRTLHRTRVKNEQPLGKLLGDAVRSSVQTLLMIGGFIILFSVVNQLLNVMHFTEQLAPLVRRLLHLVQLPEELDIPVFSGLFEITLGSQMISETDGATLLEKAVAVSFILAFGGFSVQAQVASILAEANIRFQPFLVARLLHGLFAAIFTYALWQPLYVETATRESGHIPAFFHILTYARPEEHLGLPPYGPLITMLFLCLYIWLTAKAASERPRRS
>NZ_AP022557.1|WP_033843467.1|1671995_1672502_-|pantetheine-phosphate-adenylyltransferase
MASIAVCPGSFDPVTYGHLDIIKRGARVFDQVYVAVLNNSAKKPLFTVEERIELLRAVTQSLPNVHVESFHGLLIDYARSKKANAILRGLRAVSDFEYEMQITSMNRVLDENIETFFMMTNSQYAFLSSSIVKEVAKYNGDISELVPPVVEQALKKKFASLAADGPQR
>NZ_AP022557.1|WP_033843466.1|1672467_1673064_-|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MRVISGTCKGRKLQAVPGMSTRPTTDKVKEAIFNIIGPYFSGGIGLDLFAGSGGLGIEALSRGLDRVIFVDHDRKAVQTVRKNVAACGLEKQAEIYCNDAERALKAVAKRGLRFSVIFLDPPYKENEWPALLSALAGCRLLEPGGVVVAEHSAKARLPETADGLVQWKQETYGITGVTIYRWKGDETDGEHCRLSREF
>NZ_AP022557.1|WP_033843465.1|1673069_1673258_-|hypothetical-protein
MGKRKSSPSLATMMLPLLIMARSLVSIHSRAKKFFSLTFLNFMVRLQRIDFACDKMETTKNG
>NZ_AP022557.1|WP_033022170.1|1673442_1673832_+|hypothetical-protein
MIQRFIELGEGYSDIYELIELARANRHRVSGFFAFHTVKQGRAVVSLAVVLHPTDPGDFQPLYICREGIPDPAVKPNKRYELFAETAQALGMNVIHLDVKPSTWFAERDLYYQHLIGIMRLNRFIPPLQ
>NZ_AP022557.1|WP_033022165.1|1674237_1674507_-|YlbG-family-protein
MFPQRQGIIVWLHSLKHGKQLRKFGNIHYISKRLKYAVLYCDMEQADYVMKKLAALPFVKRVEPSYRPFLKLEFESKGEKEKDSPYPLG
>NZ_AP022557.1|WP_033844843.1|1674525_1674972_-|YlbF-family-regulator
MRIATLERIEILDKAEGLAKMIVESELAEEYRRAFWRLKQDRRAQQLISRFVQLKEQYEDVQRFGKYHPDYRPIMKAVREAKRELDLHETVAAFKQAEKALQQLLDEISVLIGKAVSEHVKVPTGNPYFLSAGCSGGCRSGGGCGCRT

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Crispr_ID: NZ_AP022557_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_15

1671925-1672010

Orphan

Consensus_repeat	Method
GCTGTCCGTCATCGCTGTGGCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_15

>merge|NZ_AP022557|15|1671925-1672010|CRISPRCasFinder
GCTGTCCGTCATCGCTGTGGCTCATCGGCAAGAAAACAGGCTGTGTTGATTTGGGACGTGATCGCTGTCCGTCATCGCTGTGGCCC

>NZ_AP022557|15|15|1671925-1672010|CRISPRCasFinder
GCTGTCCGTCATCGCTGTGGCTC	ATCGGCAAGAAAACAGGCTGTGTTGATTTGGGACGTGATC
GCTGTCCGTCATCGCTGTGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843463.1\|1675295_1675655_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843462.1\|1675991_1676375_-\|YlbD-family-protein	unknown	unknown	gnl\|CDD\|372900
NZ_AP022557.1\|WP_033844843.1\|1674525_1674972_-\|YlbF-family-regulator	unknown	unknown	gnl\|CDD\|226204
NZ_AP022557.1\|WP_033843461.1\|1676455_1677463_-\|CAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|379629
NZ_AP022557.1\|WP_033843476.1\|1663173_1663560_-\|DUF3397-domain-containing-protein	unknown	unknown	gnl\|CDD\|378748
NZ_AP022557.1\|WP_011230605.1\|1666096_1666270_-\|50S-ribosomal-protein-L32	unknown	unknown	gnl\|CDD\|237038
NZ_AP022557.1\|WP_033843471.1\|1667488_1668709_+\|nucleotidyltransferase	unknown	unknown	gnl\|CDD\|237464
NZ_AP022557.1\|WP_033022159.1\|1677589_1678015_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341390
NZ_AP022557.1\|WP_033843470.1\|1668681_1669701_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|226011
NZ_AP022557.1\|WP_033843469.1\|1669697_1670486_-\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132866
NZ_AP022557.1\|WP_033843474.1\|1664545_1665121_-\|RsfA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|274342
NZ_AP022557.1\|WP_033843465.1\|1673069_1673258_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033022311.1\|1675745_1675979_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372876
NZ_AP022557.1\|WP_033843466.1\|1672467_1673064_-\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|367574
NZ_AP022557.1\|WP_172418591.1\|1670571_1671852_+\|sporulation-integral-membrane-protein-YlbJ	unknown	unknown	gnl\|CDD\|274333
NZ_AP022557.1\|WP_033843472.1\|1666415_1666958_-\|DUF177-domain-containing-protein	unknown	unknown	gnl\|CDD\|224317
NZ_AP022557.1\|WP_033022165.1\|1674237_1674507_-\|YlbG-family-protein	unknown	unknown	gnl\|CDD\|179491
NZ_AP022557.1\|WP_033843473.1\|1665194_1665950_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_AP022557.1\|WP_033022170.1\|1673442_1673832_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_051962664.1\|1663552_1664473_-\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|235821

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033844843.1\|1674525_1674972_-\|YlbF-family-regulator	gnl\|CDD\|226204	COG3679, COG3679, Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms].	7.71262e-36
NZ_AP022557.1\|WP_033843461.1\|1676455_1677463_-\|CAP-domain-containing-protein	gnl\|CDD\|379629	pfam14504, CAP_assoc_N, CAP-associated N-terminal. The function of this domain is unknown, but it is found towards the N-terminus of bacterial proteins carrying the CAP domain, pfam00188. All members that do not otherwise carry an additional Cu_amine_oxidN1, pfam07833, domain are likely to be extracellular as they start with a signal-peptide. Most other non-bacterial proteins with the CAP domain are allergenic.	3.24426e-58
NZ_AP022557.1\|WP_033843476.1\|1663173_1663560_-\|DUF3397-domain-containing-protein	gnl\|CDD\|378748	pfam11877, DUF3397, Protein of unknown function (DUF3397). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 114 to 128 amino acids in length.	1.26653e-15
NZ_AP022557.1\|WP_011230605.1\|1666096_1666270_-\|50S-ribosomal-protein-L32	gnl\|CDD\|237038	PRK12286, rpmF, 50S ribosomal protein L32; Reviewed.	5.46276e-28
NZ_AP022557.1\|WP_033843471.1\|1667488_1668709_+\|nucleotidyltransferase	gnl\|CDD\|237464	PRK13670, PRK13670, nucleotidyltransferase.	0
NZ_AP022557.1\|WP_033022159.1\|1677589_1678015_-\|CBS-domain-containing-protein	gnl\|CDD\|341390	cd04622, CBS_pair_HRP1_like, CBS pair domain found in Hypoxic Response Protein 1 (HRP1) -like proteinds. Mycobacterium tuberculosis adapts to cellular stresses by upregulation of the dormancy survival regulon. Hypoxic response protein 1 (HRP1) is encoded by one of the most strongly upregulated genes in the dormancy survival regulon. HRP1 is a 'CBS-domain-only protein; however unlike other CBS containing proteins it does not appear to bind AMP. The biological function of the protein remains unclear, but is thought to contribute to the modulation of the host immune response. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	4.39874e-53
NZ_AP022557.1\|WP_033843470.1\|1668681_1669701_-\|PDZ-domain-containing-protein	gnl\|CDD\|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	1.74639e-127
NZ_AP022557.1\|WP_033843469.1\|1669697_1670486_-\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132866	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6. Bacterial patatin-like phospholipase domain containing protein 6. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This group includes YCHK and rssA from Escherichia coli as well as Ylbk from Bacillus amyloliquefaciens.	2.11392e-72
NZ_AP022557.1\|WP_033843474.1\|1664545_1665121_-\|RsfA-family-transcriptional-regulator	gnl\|CDD\|274342	TIGR02894, DNA_bind_RsfA, transcription factor, RsfA family. In a subset of endospore-forming members of the Firmcutes, members of this protein family are found, several to a genome. Two very strongly conserved sequences regions are separated by a highly variable linker region. Much of the linker region was excised from the seed alignment for this model. A characterized member is the prespore-specific transcription RsfA from Bacillus subtilis, previously called YwfN, which is controlled by sigma factor F and seems to fine-tune expression of some genes in the sigma-F regulon. A paralog in Bacillus subtilis is designated YlbO. [Regulatory functions, DNA interactions, Cellular processes, Sporulation and germination].	3.60189e-48
NZ_AP022557.1\|WP_033022165.1\|1674237_1674507_-\|YlbG-family-protein	gnl\|CDD\|179491	PRK02886, PRK02886, hypothetical protein; Provisional.	3.25916e-50
NZ_AP022557.1\|WP_033022311.1\|1675745_1675979_-\|hypothetical-protein	gnl\|CDD\|372876	pfam14003, YlbE, YlbE-like protein. The YlbE-like protein family includes the B. subtilis protein YlbE, which is functionally uncharacterized. This family of cytosolic proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There is a conserved WYR sequence motif.	3.53198e-24
NZ_AP022557.1\|WP_033843466.1\|1672467_1673064_-\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|367574	pfam03602, Cons_hypoth95, Conserved hypothetical protein 95.	1.77754e-74
NZ_AP022557.1\|WP_172418591.1\|1670571_1671852_+\|sporulation-integral-membrane-protein-YlbJ	gnl\|CDD\|274333	TIGR02871, conserved_hypothetical_protein, sporulation integral membrane protein YlbJ. Members of this protein family are found exclusively in Firmicutes (low-GC Gram-positive bacterial) and are known from studies in Bacillus subtilis to be part of the sigma-E regulon. Mutation leads to a sporulation defect, confirming that members of this protein family, YlbJ, are sporulation proteins. This protein appears to be universal among endospore-forming bacteria, but is encoded by a pair ORFs distant from eash other in Symbiobacterium thermophilum IAM14863. [Cellular processes, Sporulation and germination].	5.10812e-150
NZ_AP022557.1\|WP_033843472.1\|1666415_1666958_-\|DUF177-domain-containing-protein	gnl\|CDD\|224317	COG1399, COG1399, Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only].	5.70194e-29
NZ_AP022557.1\|WP_033843473.1\|1665194_1665950_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	2.47854e-56
NZ_AP022557.1\|WP_033843462.1\|1675991_1676375_-\|YlbD-family-protein	gnl\|CDD\|372900	pfam14071, YlbD_coat, Putative coat protein. This is a family of putative bacterial coat proteins. Proteins in this family are approximately 140 amino acids in length.	2.30829e-48
NZ_AP022557.1\|WP_051962664.1\|1663552_1664473_-\|2-dehydropantoate-2-reductase	gnl\|CDD\|235821	PRK06522, PRK06522, 2-dehydropantoate 2-reductase; Reviewed.	1.62071e-92

>NZ_AP022557.1|WP_172418591.1|1670571_1671852_+|sporulation-integral-membrane-protein-YlbJ
MRLYRAKLHGKKGGRPLKRNWGTKGKTALLASAATLFAFALISYPKQSLEASIRGLTMWWEVVFPSLLPFFIVSELLISFGVVNFLGVLLEPLMRPLFRVPGVGGFAWAMGMASGYPSGAKLTARLYQEKQLSTIEAERLSSFTNSSNPLFIFGAVSAGFFHNPQLGFVLAASHYLGNITVGLIMRFHGIRKERGQPKSRRRPFSLPYALRTLHRTRVKNEQPLGKLLGDAVRSSVQTLLMIGGFIILFSVVNQLLNVMHFTEQLAPLVRRLLHLVQLPEELDIPVFSGLFEITLGSQMISETDGATLLEKAVAVSFILAFGGFSVQAQVASILAEANIRFQPFLVARLLHGLFAAIFTYALWQPLYVETATRESGHIPAFFHILTYARPEEHLGLPPYGPLITMLFLCLYIWLTAKAASERPRRS
>NZ_AP022557.1|WP_033843469.1|1669697_1670486_-|patatin-like-phospholipase-family-protein
MPPKIGVALGSGGARGFAHLGVLNVLEDEQIPISYLAGSSIGALVAVLYASGHGLHRLYRLAQSFRRNDFLDWTVPKMGLIAGERITQFIRLLTKGKRLEELSPPVAVVATDLRTGEKVVFREGEAARAVRASISIPGIFVPAEMNGRLLVDGGVVDRVPVSVVRAMGADLVIAVDVAPLNTNAEITSIADVIWKSLDILQAELVVHRQLASDVMIRPRVESYSSRAFTDIKEIIARGEEEARKQIAAIRRAMEQWKEPSSR
>NZ_AP022557.1|WP_033843470.1|1668681_1669701_-|PDZ-domain-containing-protein
MKRRTYIVAFVLGVVLTFLFIFIKLPYYVTMPGSAQSLRPLVHVEHGDRDAGTLMLTTVRMGRANVASYLLAHIRPFYELYPAEEIKQEGESDKDYTLRQLELMEQAKEAAIIVAYRQAGKPVSYQPRGAYVMSVLSDMPAAGRLKTGDLIVALDGKPLATSEQMVSYLRGKKAGDRVRVTFIRGGKRREAEIALRPFPDHPDQAGLGVMPVTEYDIRTDPPVEIDSEQIGGPSAGLMFSLEIYNQLVPEDITKGHKIAGTGTIDLNGNVGPIGGVSQKVVAADREGAEVFFAPNEHGAPASNYREALRTAKQIGTKMKIVPVDTFDDAIRYLRSMPEK
>NZ_AP022557.1|WP_033843471.1|1667488_1668709_+|nucleotidyltransferase
MKAVGVIVEYNPFHNGHLHHLQETRRKTNADCLIAVMSGNFLQRGEPAIVSKWARTKMALASGIDIVIELPYAFAVQAAERFASGAVRLLAAIGCRELCFGSESGDIAAFLSAADTWSEQQEPFDSLVRAELARGQSFPRAAAAAWQALGAAPLDLSKPNNVLGFAYVKAIRQHALPMTPHTIPRRAAGYHDESASHPSIASATSVRKILRQTGQLEAVAAYVPAAALDQLRQYQETYGRLHDWEMYFPLLKYRLLTATEADLRRIAGVEEGIEHRLKQHIAAAETFAAFIAAVKTKRYTWTRLQRLCTHVLTHFTKEAQSEAADPTYIRLLGMSETGRRYLQQVKKQLALPLVAKAAKLNGDPLYEQEKRAAAAYAAAFPEPLASRAFREEYATAPIYFSGMERK
>NZ_AP022557.1|WP_033843472.1|1666415_1666958_-|DUF177-domain-containing-protein
MKWTVQQLRRFQHKEMVIDETIDVSDLKQIDTLIRDISPVRVQGKADVASTKFTFHLTLSGTMVLPCSRTLVDVHYPFSIETTETFFAEGGGLAETDDDTHVLTGDTVDLHPIIRELILLEIPLQLIADSPAVDGAPQHGEGWDVLTEDEWEKVVQEREANKVDPRLAGLAKFFEEKREK
>NZ_AP022557.1|WP_011230605.1|1666096_1666270_-|50S-ribosomal-protein-L32
MAVPFRRTSKTRKRLRRTHFKLQVPGMVQCPNCGEWKLAHRVCKACGTYKGRDVVNK
>NZ_AP022557.1|WP_033843473.1|1665194_1665950_-|enoyl-CoA-hydratase/isomerase-family-protein
MEAKMEYEAGVGLFTICRPEKRNAINFAVMEALEEAMKRAAADEHVKVFAITGAGGEAFCSGGDLHEFGHLRGAEAKQMLTRMGELLYKLLTFPKPTVALVNGTAIGGGCELATACDIRLVKEGSRIGFVQGRLGITTGWGGASMLFAKLPYGQALDVLLRAELMTAEEMKARGWTDAIVPAESWREQWRQRLAVYTERSLAVLQAYKATAGEKWRTAWFREQFFTEIDRCAELWGSREHEQALRAFLHKK
>NZ_AP022557.1|WP_033843474.1|1664545_1665121_-|RsfA-family-transcriptional-regulator
MTGIRQDAWTKEEDELLAKVVLQYIREGNTQLEAFAEVGRRLSRTAAACGFRWNSCVRKQYKEDIELAKQERKRRKKEVAAIKESGGWAKVEAEGKQHLSWPDVLAFLQAEEQKAREARRAADENRALKNDMEQLQQMVTKLQMEKEALEKQLATVQEEYKTLLAIMERARQMVADHEKPEPNEADGAGES
>NZ_AP022557.1|WP_051962664.1|1663552_1664473_-|2-dehydropantoate-2-reductase
MSRKRGRGSLKIGIVGGGAVGLLLAAYLGRHHEVTMYTRRLAQAKQLAEQGVALEKDGETTTVAVRARPFADAELDEPLVFVAVKQYDLDAIWARADAFRRVRTLVFVQNGMGHLDSLPLLVGQTILAGVVEHGAWKRDDRTVVHTGVGKLTLAVRFGSIGDARELQSDDPHFPIEWVDDWKRMLVDKLVVNAVINPLTALLQVNNGALLEVAPYREMMAQLFDEVRQALALADEQRAWERIVHICRKTADNYSSMYMDLAHGRRTEIDAILGYVLQQGEARGVALPLIRFLFCAIKGKEGREEDG
>NZ_AP022557.1|WP_033843476.1|1663173_1663560_-|DUF3397-domain-containing-protein
MDEWLASALATFITAPLLLFLLVYVGARLFGRRKRSSFYAAVNAATVFFIAAVYFLLAVVFHRSYLVPLLLFLFVLHALIALGYWRKQGDFRLRAVFRLFWRASFLIFASLYAGLMVYGIVVRIAASL
>NZ_AP022557.1|WP_033843466.1|1672467_1673064_-|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MRVISGTCKGRKLQAVPGMSTRPTTDKVKEAIFNIIGPYFSGGIGLDLFAGSGGLGIEALSRGLDRVIFVDHDRKAVQTVRKNVAACGLEKQAEIYCNDAERALKAVAKRGLRFSVIFLDPPYKENEWPALLSALAGCRLLEPGGVVVAEHSAKARLPETADGLVQWKQETYGITGVTIYRWKGDETDGEHCRLSREF
>NZ_AP022557.1|WP_033843465.1|1673069_1673258_-|hypothetical-protein
MGKRKSSPSLATMMLPLLIMARSLVSIHSRAKKFFSLTFLNFMVRLQRIDFACDKMETTKNG
>NZ_AP022557.1|WP_033022170.1|1673442_1673832_+|hypothetical-protein
MIQRFIELGEGYSDIYELIELARANRHRVSGFFAFHTVKQGRAVVSLAVVLHPTDPGDFQPLYICREGIPDPAVKPNKRYELFAETAQALGMNVIHLDVKPSTWFAERDLYYQHLIGIMRLNRFIPPLQ
>NZ_AP022557.1|WP_033022165.1|1674237_1674507_-|YlbG-family-protein
MFPQRQGIIVWLHSLKHGKQLRKFGNIHYISKRLKYAVLYCDMEQADYVMKKLAALPFVKRVEPSYRPFLKLEFESKGEKEKDSPYPLG
>NZ_AP022557.1|WP_033844843.1|1674525_1674972_-|YlbF-family-regulator
MRIATLERIEILDKAEGLAKMIVESELAEEYRRAFWRLKQDRRAQQLISRFVQLKEQYEDVQRFGKYHPDYRPIMKAVREAKRELDLHETVAAFKQAEKALQQLLDEISVLIGKAVSEHVKVPTGNPYFLSAGCSGGCRSGGGCGCRT
>NZ_AP022557.1|WP_033843463.1|1675295_1675655_-|hypothetical-protein
MSLPKRLKSLAGAMLFVVFAFWALAPAHAERADAPLHINHEVKGSDVFIECFAPRFPFRQGSGGGHVDVYVNGQKVTQVYTAAFVVRGLPSGTHHIRLEFVYNDGRTAGVGHEFDVSIP
>NZ_AP022557.1|WP_033022311.1|1675745_1675979_-|hypothetical-protein
MRKDVWQYVQGQPMLRAFLREQPRWYRILARRPHELAAFQLAALRHYELTIPDKVKKFSQSLQMASLMWQVFKAMRD
>NZ_AP022557.1|WP_033843462.1|1675991_1676375_-|YlbD-family-protein
MAKPLHPSVEQFKQFVKKHPKLIQEVRSGKKTWKQVYEDWYLFGEDDEIWDPYRERDGKRNEGEKGASKWLDKLAAMLGQMDAAEVQKHLANVQQAIGAIQSILSEFQGASQQRPNKDEHPFSFRKD
>NZ_AP022557.1|WP_033843461.1|1676455_1677463_-|CAP-domain-containing-protein
MKWMFLFLLLFIGLYFFTPSPPPPSPPGQPEINGHMLKEPKATAGLVTLIGQPVQAVNQQLGRPDRVDPSAYGYEWWVYRRHLDSYVQVGVARGKVVTILAGGERVNVEPFAVGQRLQTIFQTMPVLSNIKIQLPSGTYRFELSEQDYSTRPVVKVGAVYAQLYVDRFTDQVAAVRLMDGETFVKLRPYELVYRGHLPDVPTLSEEQQRMVDAGNAKQIFDWTNLFRRRHELSVLAWDDDAAAAAAKHSRDMHDHQFFSHKSPRYGDLSERLQALRIPFRVAGENIAAHQVDGVEAAIGWLNSEKHREIMMNREFTHLGVGVYGDYYTQNFFTPR
>NZ_AP022557.1|WP_033022159.1|1677589_1678015_-|CBS-domain-containing-protein
MQTVRDIMSTDVQYCTPLDNMYEAAVKMRDFDIGAIPIVDEGRLVGMITDRDLVVRGIAEKHPGSTAVTEVMSRDITAVSPDDSVQAAADLMAHHQIRRLPVVENGRLVGMVSLGDLAVNRYSDERAGRALSDISEPARHP

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Crispr_ID: NZ_AP022557_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_16

1714334-1714429

Orphan

Consensus_repeat	Method
CCTATTGTACCAAAAAATGCGGCCACTGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_16

>merge|NZ_AP022557|16|1714334-1714429|CRISPRCasFinder
CCTATTGTACCAAAAAATGCGGCCACTGACGCAAGATAGGGGGCGGTAGGTAACCGAATGCTTTCTCCCTATTGTACCAAAAATGCGGCCACTGAC

>NZ_AP022557|16|16|1714334-1714429|CRISPRCasFinder
CCTATTGTACCAAAAAATGCGGCCACTGAC	GCAAGATAGGGGGCGGTAGGTAACCGAATGCTTTCT
CCCTATTGTACCAAAAATGCGGCCACTGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843439.1\|1710245_1711022_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319819
NZ_AP022557.1\|WP_033022097.1\|1711478_1711694_+\|DNA-dependent-RNA-polymerase-auxiliary-subunit-epsilon-family-protein	unknown	unknown	gnl\|CDD\|184224
NZ_AP022557.1\|WP_033843438.1\|1711690_1713358_+\|ribonuclease-J	unknown	unknown	gnl\|CDD\|223668
NZ_AP022557.1\|WP_033843429.1\|1721325_1722093_-\|2,4-dienoyl-CoA-reductase	unknown	unknown	gnl\|CDD\|181077
NZ_AP022557.1\|WP_033843431.1\|1719647_1720865_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|371022
NZ_AP022557.1\|WP_156102705.1\|1722234_1722408_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033022113.1\|1703850_1704093_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843441.1\|1708002_1709112_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_AP022557.1\|WP_033843436.1\|1715340_1716477_-\|N-acetyldiaminopimelate-deacetylase	unknown	unknown	gnl\|CDD\|349920
NZ_AP022557.1\|WP_033022111.1\|1704237_1705650_-\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|235798
NZ_AP022557.1\|WP_033843433.1\|1718867_1719065_-\|antirepressor-AbbA	unknown	unknown	gnl\|CDD\|372933
NZ_AP022557.1\|WP_033843442.1\|1705654_1706950_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_AP022557.1\|WP_172418593.1\|1717319_1718192_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_AP022557.1\|WP_033843437.1\|1713630_1714293_-\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NZ_AP022557.1\|WP_033843432.1\|1719363_1719597_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843434.1\|1718289_1718766_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341400
NZ_AP022557.1\|WP_033022086.1\|1716535_1717246_-\|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-acetyltransferase	unknown	unknown	gnl\|CDD\|132571
NZ_AP022557.1\|WP_033022091.1\|1715052_1715295_-\|YkuS-family-protein	unknown	unknown	gnl\|CDD\|179536
NZ_AP022557.1\|WP_033843440.1\|1709638_1710193_+\|peptide-deformylase	unknown	unknown	gnl\|CDD\|234668
NZ_AP022557.1\|WP_033022105.1\|1707021_1707999_-\|pyruvate-dehydrogenase-complex-E1-component-subunit-beta	unknown	unknown	gnl\|CDD\|223101

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033843439.1\|1710245_1711022_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319819	cd07517, HAD_HPP, phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily. Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.05473e-113
NZ_AP022557.1\|WP_033022097.1\|1711478_1711694_+\|DNA-dependent-RNA-polymerase-auxiliary-subunit-epsilon-family-protein	gnl\|CDD\|184224	PRK13667, PRK13667, hypothetical protein; Provisional.	1.32155e-31
NZ_AP022557.1\|WP_033843438.1\|1711690_1713358_+\|ribonuclease-J	gnl\|CDD\|223668	COG0595, COG0595, mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair].	0
NZ_AP022557.1\|WP_033843429.1\|1721325_1722093_-\|2,4-dienoyl-CoA-reductase	gnl\|CDD\|181077	PRK07677, PRK07677, short chain dehydrogenase; Provisional.	2.53738e-180
NZ_AP022557.1\|WP_033843431.1\|1719647_1720865_-\|EAL-domain-containing-protein	gnl\|CDD\|371022	pfam10388, YkuI_C, EAL-domain associated signalling protein domain. In Bacillus species this highly conserved region of the YkuI protein lies immediately downstream of the EAL (diguanylate cyclase/phosphodiesterase domain 2) pfam00563 domain so that together they form a monomer which dimerizes for its enzymatic action. The region contains three alpha helices and five beta strands and is the C-terminal half of the structure.	1.02525e-98
NZ_AP022557.1\|WP_033843441.1\|1708002_1709112_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	0
NZ_AP022557.1\|WP_033843436.1\|1715340_1716477_-\|N-acetyldiaminopimelate-deacetylase	gnl\|CDD\|349920	cd05670, M20_Acy1_YkuR-like, M20 Peptidase aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins. Peptidase M20 family, aminoacyclase-1 YkuR-like subfamily including YkuR and Ama/HipO/HyuC proteins, most of which have not been well characterized to date. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity; substrates include indoleacetic acid (IAA) N-conjugates of amino acids, N-acetyl-L-amino acids and aminobenzoylglutamate. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as in the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine). ACY1 appears to physically interact with Sphingosine kinase type 1 (SphK1) and may influence its physiological functions; SphK1 and its product sphingosine-1-phosphate have been shown to promote cell growth and inhibit apoptosis of tumor cells. Strong expression of the human gene and its mouse ortholog Acy1 in brain, liver, and kidney suggest a role of the enzyme in amino acid metabolism of these organs.	0
NZ_AP022557.1\|WP_033022111.1\|1704237_1705650_-\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|235798	PRK06416, PRK06416, dihydrolipoamide dehydrogenase; Reviewed.	0
NZ_AP022557.1\|WP_033843433.1\|1718867_1719065_-\|antirepressor-AbbA	gnl\|CDD\|372933	pfam14156, AbbA_antirepres, Antirepressor AbbA. This family inactivates the repressor AbrB, which represses genes switched on during the transition from the exponential to the stationary phase of growth. It binds to AbrB and prevents it from binding to DNA.	8.94955e-22
NZ_AP022557.1\|WP_033843442.1\|1705654_1706950_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	0
NZ_AP022557.1\|WP_172418593.1\|1717319_1718192_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.30793e-43
NZ_AP022557.1\|WP_033843437.1\|1713630_1714293_-\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	2.70788e-70
NZ_AP022557.1\|WP_033843434.1\|1718289_1718766_-\|CBS-domain-containing-protein	gnl\|CDD\|341400	cd04643, CBS_pair_bac, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	2.27685e-76
NZ_AP022557.1\|WP_033022086.1\|1716535_1717246_-\|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-acetyltransferase	gnl\|CDD\|132571	TIGR03532, DapD_Ac, 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase. This enzyme is part of the diaminopimelate pathway of lysine biosynthesis. Alternate name: tetrahydrodipicolinate N-acetyltransferase. Note that IUBMB lists this alternate name as the accepted name. Unfortunately, the related succinyl transferase acting on the same substrate (EC:2.3.1.117, TIGR00695) uses the opposite standard. We have decided to give these two enzymes names which more clearly indicated that they act on the same substrate.	9.8383e-135
NZ_AP022557.1\|WP_033022091.1\|1715052_1715295_-\|YkuS-family-protein	gnl\|CDD\|179536	PRK03094, PRK03094, hypothetical protein; Provisional.	5.14687e-44
NZ_AP022557.1\|WP_033843440.1\|1709638_1710193_+\|peptide-deformylase	gnl\|CDD\|234668	PRK00150, def, peptide deformylase; Reviewed.	1.02779e-69
NZ_AP022557.1\|WP_033022105.1\|1707021_1707999_-\|pyruvate-dehydrogenase-complex-E1-component-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	0

>NZ_AP022557.1|WP_033843437.1|1713630_1714293_-|TrkA-family-potassium-uptake-protein
MKKKQFAVIGLGRFGGSICRTLSEQGMEVLAIDIDEDRVNEFASIASHAVVGDTTDENVLKSLGIRNFDHVIVAIGDNIQASILTTLILKELGVDHITVKATNDYHEKVLKKIGADQIVHPERDMGERIAHNLISNNVLDYLELSDQYSIVEIVASQRLDGHSLLELDIRARYGINIVAIKRGASVIVSPLASEIIRKGDVLVVIGADSDIDRFEEEVVG
>NZ_AP022557.1|WP_033843438.1|1711690_1713358_+|ribonuclease-J
MKLLTDEQVGVFALGGLGEIGKNTYGVQFQDEIIVIDAGIKFPEDELLGIDYVIPDYSYLVKHADKVKGLFITHGHEDHIGGIPYLLRQVNIPIYGGKLALGLIRNKLEEHGLLRQAKLIEIREDDVIRFQKTAVTFFRTTHSIPDSYGIVVKTPVGQIVHTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLMSDSTNSEIPHFTMSERRVGESIHDIFRKVEGRIIFATFASNIHRLQQVTEAAVANNRKIAVFGRSMEAAIEIGQDLGYIKCPKGTFVDANEINRLPAHRVTILCTGSQGEPMAALSRIASGTHRQIQIIPGDTVVFSSSPIPGNTVSVNRTINMLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMIRLMKPKYFMPIHGEYRMQKMHAKLAIDCGVPEENCFIMDNGEVLGISDKEARIVGKIPSGSVYIDGSGVGDIGNIVLRDRRILSEEGLVIVVVSINMKDFKIAAGPDIISRGFVYMRESGDLINEAQALIAKHLAKVLERKTNQWSEIKNEITETLAPFLYERTKRRPMILPIIMEI
>NZ_AP022557.1|WP_033022097.1|1711478_1711694_+|DNA-dependent-RNA-polymerase-auxiliary-subunit-epsilon-family-protein
MIFKVFYQENADEVPVREKTKTLYIEAESEREVRRKLDGRSINIEYIQPLEGAHLDYEKKSPNFQVLETSS
>NZ_AP022557.1|WP_033843439.1|1710245_1711022_-|Cof-type-HAD-IIB-family-hydrolase
MDQKMVFFDIDGTLLDERKQLPPSTIEAIRRLKQSGVYVAIATGRAPFMFEHVRKQLGIDSFVSFNGQYVVFEGTVLHKQPLRREKLRELARAAHENGHPLVFMDAEEMRASVGDHPHIHVSMGSLKFAHPPVDPLYYENNDIYQALLFCHAAEEQPYVHQYPEFRFVRWHDVSTDVLPAGGSKAEGIRLMIKKLGIDKKNVYAFGDGLNDIEMLSFVGTGVAMGNAHEEVKRVADFVTKSVDQEGIWYGLKQLQLIR
>NZ_AP022557.1|WP_033843440.1|1709638_1710193_+|peptide-deformylase
MITMKDIIKEGHPTLRKVAEPVPLPPSQEDQRILQSLLDYVKMSQDPELAAKYGLRPGIGLAAPQINVSKRMIAVHITDENGTLHSYALFNPKIVSHSVQQCYLTTGEGCLSVDRDVPGYVPRYARITVTGTTIDGEDVTLRLKGLPAIVFQHEIDHLNGIMFYDRINPDDPFQVPDGAIPIGR
>NZ_AP022557.1|WP_033843441.1|1708002_1709112_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MGVKTSQFRFAEQLEKVAEQFPMFQILNEKGEVTNEEAMPELSDEQLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEASQIGSHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSRGHFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGKKAVAITYTGDGGTSQGDFYEGINFAGAFQAPAIFVVQNNRFAISTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDVLAVYAAVKAARERAVNGEGPTLIETLCFRYGPHTMSGDDPTRYRSKELENEWAKKDPLVRFRKFLEAKGLWSEEEENRVIEQAKEDIKEAIKKADETPKQKVTDLISIMYEELPFNLKEQYEIYKEKESK
>NZ_AP022557.1|WP_033022105.1|1707021_1707999_-|pyruvate-dehydrogenase-complex-E1-component-subunit-beta
MAQMTMVQAITDALRIELKNDPNVLVFGEDVGVNGGVFRATEGLQAEFGEERVFDTPLAESGIGGLAIGLALQGFRPVPEIQFFGFVYEVMDSICGQMARIRYRTGGRYHMPITVRSPFGGGVHTPELHSDSLEGLVAQQPGLKVVIPSTPYDAKGLLISAIRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKREGKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQPLDIETIIGSVEKTGRAIVVQEAQRQAGIAANVVAEINERAILSLEAPVLRVAAPDTVYPFAQAESVWLPNFKDVIETAKKAINF
>NZ_AP022557.1|WP_033843442.1|1705654_1706950_-|2-oxo-acid-dehydrogenase-subunit-E2
MAFEFKLPDIGEGIHEGEIVKWFVKPGDEVNEDDVLCEVQNDKAVVEIPSPVKGKVLEIVVPEGTVATVGQTLITLDAPGYENMTFKGQEHEEETKKEEKAETVSKEENGGTAASAAADAEPNRRVIAMPSVRKYAREKGVDIRLVQGTGKNGRVLKEDIDTFLAGGAKAAAPSAAQAPEEKAAPQAPTAKPVVPEGEFPETREKMSGIRRAIAKAMVHSKHTAPHVTLMDEVDVTKLVAHRKKFKAIAADKGIKLTFLPYVVKALVSALREYPALNTSIDDASEEIIHKHYYNIGIAADTDRGLLVPVIKHADRKPIFALAKEINELAEKARDGKLAPNEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKPIVRDGEIVAAPVLALSLSFDHRMIDGATAQKALNHIKQLLSDPELLLMEA
>NZ_AP022557.1|WP_033022111.1|1704237_1705650_-|dihydrolipoyl-dehydrogenase
MVVGDFAIETETLVVGAGPGGYVAAIRAAQLGQKVTIVEKGNLGGVCLNVGCIPSKALISAGHRYEQAKHSEEMGIKAENVTVDFAKVQEWKASVVKKLTSGVEGLLKGNKVEIVKGEAYFVDANTVRVVNGDSAQTYTFKNAIIATGSRPIELPNFKFSNRILDSTGALNLGEIPKSLVVIGGGYIGIELGTAYANFGAKVTILEGAGEILSGFEKQMVSIIKRRLQKKGVDVVTNALAKGAEERADGVTVTYEANGETKTVDADYVLVTVGRRPNTDELGLEQIGVKMTERGLIEVDDQCRTSVPNIFAIGDIVPGPALAHKASYEGKVAAEAIAGHPSAVDYVAIPAVVFSDPECASVGYFEQQAKEEGIDVIAAKFPFAANGRALSLNDTEGFVKLVVRKEDGVVIGAQIVGPNASDMIAELGLAIEAGMTAEDIALTIHAHPTLGEIAMEAAEVALGTPIHIVTK
>NZ_AP022557.1|WP_033022113.1|1703850_1704093_-|hypothetical-protein
MKAYVAFLVQMMIWSSFSIIEWLSGRDRPFFRGVMLCVFMYIAFLLARRLGLATRQAALTTIGTAAVYFAGQQWVWQAVQ
>NZ_AP022557.1|WP_033022091.1|1715052_1715295_-|YkuS-family-protein
MAKIGVEPSLTDVQEALRERGHDVVPLRGEQDAKGCDCCVITGLDANVAGMQNAVTSGPVVEASGLSAEEICQKVEEKLR
>NZ_AP022557.1|WP_033843436.1|1715340_1716477_-|N-acetyldiaminopimelate-deacetylase
MKAISRFVAIRRDLHQIPELGFQEVKTQHYLLRYIQSLPQERLQVRTWKTGIFVKVNGTSPRKTIGYRADMDGLPIREETGLPYRSTHDGCMHACGHDVHMSIALGVLTHFAHHPIQDDLLFIFQPAEEGPGGAKPMIESDIMQEWKPDMILALHIAPEYPVGTIATKEGLLFANTSELFIDLKGKGGHAAFPHLANDMVVAACALVTQLQSIVARNVDPLDSAVITIGKITGGTVQNVIAERARLEGTIRTLSAAAMQKVKRRIEAIVHGVEVAYECEAAIDYGAMYHQVYNDPELTAEFMKFAAAHGGVNVISCKEAMTGEDFGYMLADIPGFMFWLGVESPYGLHHAKLAPNEEAIDRAIAFLIDYFSWKGNSEV
>NZ_AP022557.1|WP_033022086.1|1716535_1717246_-|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-acetyltransferase
MKMMDANEIISFIQNSKKSTPVKVYIKGELDGIDFGPSAKTFMTGNVGIVFGEWQDIQAAIEANQDKIEDYVVENDRRNSAIPLLDLKGIKARIEPGAIIRDHVEIGDNAVIMMGAVINIGAVVGEGTMIDMNAVLGGRATVGKNCHIGAGAVLAGVIEPPSAKPVVIEDDVLVGANAVILEGVTVGKGAVVAAGAVVVEDVPPYTVVAGVPARVIKQIDEQTRAKTEMKQELRQL
>NZ_AP022557.1|WP_172418593.1|1717319_1718192_-|LysR-family-transcriptional-regulator
MNSSEYEILAVLAEELNMRKAAARLYVTQSALSQRLQAIEAGWNVKIFIRSPRGLLLTPEGEKIVQLAKETVQKTKRDKEEIQRRVGQISGTLTIAVTSIVAQHWLPPVLKTFIKLYPDVNVSLTTGWTSEVLSHMYENRFQLGIVRGEPNWSGIATRLFTDQLYLVDQEIHDLEQLRHTERPFIQFKSDSTYSLHIQQWWHEQFQALPARTVMVDQIETCKQLAYHGVGYAILPEIALDDREQYVVHMIPLKNKRGEPMTRDTWLISSEAAWQLPQVQAFEKVLRRFVP
>NZ_AP022557.1|WP_033843434.1|1718289_1718766_-|CBS-domain-containing-protein
MTWLKDKEAVPMTVKPFLISADKVAHVQPENYLDHALLVLTKTGYSAIPVLDTSYKLQGLISITMIMDAILGLERIEFERLETMKVEDVMNRNIPRLRLTDSLTKAIGLIVNHPFVCVENDDGYFAGIFTRREILKQLNKQLHKSNGGRKTDRKEAEQ
>NZ_AP022557.1|WP_033843433.1|1718867_1719065_-|antirepressor-AbbA
MAKRLPPELSGEEAMLLLDVLFSQQYALELVRSELADIENGDKKADEQRYRQLLRLYDRLCTEET
>NZ_AP022557.1|WP_033843432.1|1719363_1719597_-|hypothetical-protein
MAQLAFVLSILSVLIAVIGFVYTVRLGRQQRWQGELDGPIPKPVEEHAYLRNPMLLAYVLAALLAAFAIGYLALQSY
>NZ_AP022557.1|WP_033843431.1|1719647_1720865_-|EAL-domain-containing-protein
MDALDVMANLSQVVPHYQPIFSADEHGVIGYEVLGRFQTEEGPVSLGPFFHDETIPEEFRMEVDDVITKKALDYFLSLDDETLLIFFNRDANLLMLDRGESFLQLLFAYQAKGLALDRIVLEINEQHFKGDLDQLSHLLTYIRTYGIRVAVDNIAEHSIHLERIGVLSPDILKIDLHELRKTSVHQAYQEIVHSISLLARKIGATLLYEDIETSFQLQYAWRHGGRYYQGYYLAKPGPEVVPRDLLKDLLRKECHRFIQQEKKKLETLYHISEQFQQRIAALLGKYKKAGGFNELISLLADELDDVCFRIYVCDEDGFQQSGNMFKRDGRWTLEPQYYMKNWSWRPYFLENIIRMRSRRRGILSDLYTDIETGETIRTYSYPIDERHYLFIDLSYSYLFEHDAHY
>NZ_AP022557.1|WP_033843429.1|1721325_1722093_-|2,4-dienoyl-CoA-reductase
MNGKVIIVTGGSSGMGKYMAKRFVAEGADVVITGRRAEALEEAKREMETPGGGRVLVVPMDVRNPEQVADMVARADAEFGRIDALVNNAAGNFICPAEKLSINGWNSVINIVLNGTFYCSREVGNYWIQRGLKGNIINIIATYAWHAGAGVIHSACAKAGVLAMTRTLAVEWGKKYGFRVNAIAPGPIERTGGAERLWESEEAERMTLESVPLGRLGTPEEIAAVASFLLSDEAAYINGACITVDGGQWLNRRPF
>NZ_AP022557.1|WP_156102705.1|1722234_1722408_+|hypothetical-protein
MPHMEPTYMNRRAFFKKGVRTGPTATLTASSSFGDVRWSAARFLAPPELTVFSLACR

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Crispr_ID: NZ_AP022557_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_17

1778479-1778574

Orphan

Consensus_repeat	Method
CTTTACTCATCAATATCGCGCTTTTGCTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_17

>merge|NZ_AP022557|17|1778479-1778574|CRISPRCasFinder
CTTTACTCATCAATATCGCGCTTTTGCTTCTCGTCAAAACGGACGGCGATCATGTCGGCCATCGTACTTTACTCATCAATATCGCGCTTTTGCTTC

>NZ_AP022557|17|17|1778479-1778574|CRISPRCasFinder
CTTTACTCATCAATATCGCGCTTTTGCTTC	TCGTCAAAACGGACGGCGATCATGTCGGCCATCGTA
CTTTACTCATCAATATCGCGCTTTTGCTTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033843399.1\|1775399_1776071_-\|7-cyano-7-deazaguanine-synthase-QueC	unknown	unknown	gnl\|CDD\|182967
NZ_AP022557.1\|WP_081897190.1\|1769879_1770056_+\|DUF2187-family-protein	unknown	unknown	gnl\|CDD\|227210
NZ_AP022557.1\|WP_033017652.1\|1791826_1793845_+\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_AP022557.1\|WP_082799314.1\|1790280_1791705_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129983
NZ_AP022557.1\|WP_172418596.1\|1794175_1794745_-\|phosphate-propanoyltransferase	unknown	unknown	gnl\|CDD\|237899
NZ_AP022557.1\|WP_033017655.1\|1787778_1789473_-\|M3-family-oligoendopeptidase	unknown	unknown	gnl\|CDD\|341069
NZ_AP022557.1\|WP_033017658.1\|1784607_1786743_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NZ_AP022557.1\|WP_081130697.1\|1772343_1773717_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_AP022557.1\|WP_033843398.1\|1776240_1777353_-\|GerAB/ArcD/ProY-family-transporter	unknown	unknown	gnl\|CDD\|281794
NZ_AP022557.1\|WP_172418595.1\|1771304_1772201_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033017657.1\|1786995_1787604_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033844836.1\|1770088_1770748_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|187560
NZ_AP022557.1\|WP_033843401.1\|1774231_1774966_-\|7-carboxy-7-deazaguanine-synthase-QueE	unknown	unknown	gnl\|CDD\|274545
NZ_AP022557.1\|WP_033843397.1\|1777379_1778468_-\|Ger(x)C-family-spore-germination-protein	unknown	unknown	gnl\|CDD\|274338
NZ_AP022557.1\|WP_033843400.1\|1774965_1775403_-\|6-carboxytetrahydropterin-synthase-QueD	unknown	unknown	gnl\|CDD\|223792
NZ_AP022557.1\|WP_033017703.1\|1794920_1795382_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_AP022557.1\|WP_033843395.1\|1783579_1784338_-\|FixH-family-protein	unknown	unknown	gnl\|CDD\|379037
NZ_AP022557.1\|WP_033843404.1\|1768883_1769468_+\|cell-wall-hydrolase	unknown	unknown	gnl\|CDD\|213747
NZ_AP022557.1\|WP_051985027.1\|1780495_1782157_+\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_AP022557.1\|WP_033017661.1\|1782221_1783262_-\|membrane-protein	unknown	unknown	gnl\|CDD\|226458

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033843399.1\|1775399_1776071_-\|7-cyano-7-deazaguanine-synthase-QueC	gnl\|CDD\|182967	PRK11106, PRK11106, queuosine biosynthesis protein QueC; Provisional.	1.26552e-119
NZ_AP022557.1\|WP_081897190.1\|1769879_1770056_+\|DUF2187-family-protein	gnl\|CDD\|227210	COG4873, COG4873, Uncharacterized protein conserved in bacteria [Function unknown].	1.27785e-24
NZ_AP022557.1\|WP_033017652.1\|1791826_1793845_+\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.41288e-139
NZ_AP022557.1\|WP_172418596.1\|1794175_1794745_-\|phosphate-propanoyltransferase	gnl\|CDD\|237899	PRK15070, PRK15070, phosphate propanoyltransferase.	2.50329e-127
NZ_AP022557.1\|WP_033017655.1\|1787778_1789473_-\|M3-family-oligoendopeptidase	gnl\|CDD\|341069	cd09606, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3 oligopeptidase F (oligendopeptidase) is mostly bacterial and includes oligoendopeptidase F from Geobacillus stearothermophilus. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids and may cleave proteins at Leu-Gly. The PepF gene is duplicated in Lactococcus lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid.	0
NZ_AP022557.1\|WP_033017658.1\|1784607_1786743_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NZ_AP022557.1\|WP_081130697.1\|1772343_1773717_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.25216e-16
NZ_AP022557.1\|WP_033843398.1\|1776240_1777353_-\|GerAB/ArcD/ProY-family-transporter	gnl\|CDD\|281794	pfam03845, Spore_permease, Spore germination protein.	1.52813e-73
NZ_AP022557.1\|WP_082799314.1\|1790280_1791705_+\|amino-acid-permease	gnl\|CDD\|129983	TIGR00905, Arginine/ornithine_antiporter, transporter, basic amino acid/polyamine antiporter (APA) family. This family includes several families of antiporters that, rather commonly, are encoded next to decarboxylases that convert one of the antiporter substrates into the other. This arrangement allows a cycle that can remove proteins from the cytoplasm and thereby protect against acidic conditions. [Transport and binding proteins, Amino acids, peptides and amines].	7.57582e-102
NZ_AP022557.1\|WP_033844836.1\|1770088_1770748_-\|oxidoreductase	gnl\|CDD\|187560	cd05250, CC3_like_SDR_a, CC3(TIP30)-like, atypical (a) SDRs. Atypical SDRs in this subgroup include CC3 (also known as TIP30) which is implicated in tumor suppression. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine rich NAD(P)-binding motif that resembles the extended SDRs, and have an active site triad of the SDRs (YXXXK and upstream Ser), although the upstream Asn of the usual SDR active site is substituted with Asp. For CC3, the Tyr of the triad is displaced compared to the usual SDRs and the protein is monomeric, both these observations suggest that the usual SDR catalytic activity is not present. NADP appears to serve an important role as a ligand, and may be important in the interaction with other macromolecules. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.35087e-78
NZ_AP022557.1\|WP_033843401.1\|1774231_1774966_-\|7-carboxy-7-deazaguanine-synthase-QueE	gnl\|CDD\|274545	TIGR03365, Bsubt_queE, 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE. This uncharacterized enzyme, designated QueE, participates in the biosynthesis, from GTP, of 7-cyano-7-deazaguanosine, also called preQ0 because in many species it is a precursor of queuosine. In most Archaea, it is instead the precursor of a different tRNA modified base, archaeosine. [Protein synthesis, tRNA and rRNA base modification].	2.88392e-156
NZ_AP022557.1\|WP_033843397.1\|1777379_1778468_-\|Ger(x)C-family-spore-germination-protein	gnl\|CDD\|274338	TIGR02887, Spore_germination_protein_B3, germination protein, Ger(x)C family. Members of this protein family are restricted to endospore-forming members of the Firmicutes lineage of bacteria, including the genera Bacillus, Clostridium, Thermoanaerobacter, Carboxydothermus, etc. Members are nearly all predicted lipoproteins and belong to probable transport operons, some of which have been characterized as crucial to germination in response to alanine. Members typically have been gene symbols gerKC, gerAC, gerYC, etc. [Transport and binding proteins, Amino acids, peptides and amines, Cellular processes, Sporulation and germination].	6.65777e-98
NZ_AP022557.1\|WP_033843400.1\|1774965_1775403_-\|6-carboxytetrahydropterin-synthase-QueD	gnl\|CDD\|223792	COG0720, COG0720, 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism].	2.3294e-35
NZ_AP022557.1\|WP_033017703.1\|1794920_1795382_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.27997e-23
NZ_AP022557.1\|WP_033843395.1\|1783579_1784338_-\|FixH-family-protein	gnl\|CDD\|379037	pfam13115, YtkA, YtkA-like.	1.04568e-10
NZ_AP022557.1\|WP_033843404.1\|1768883_1769468_+\|cell-wall-hydrolase	gnl\|CDD\|213747	TIGR02869, Spore_cortex-lytic_enzyme, spore cortex-lytic enzyme. Members of this protein family are the spore cortex-lytic enzyme SleB from Bacillus subtilis and other Gram-positive, endospore-forming bacterial species. This protein is stored in an inactive form in the spore and activated during germination. [Cellular processes, Sporulation and germination].	2.69133e-43
NZ_AP022557.1\|WP_051985027.1\|1780495_1782157_+\|chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	2.66399e-42
NZ_AP022557.1\|WP_033017661.1\|1782221_1783262_-\|membrane-protein	gnl\|CDD\|226458	COG3949, COG3949, Uncharacterized membrane protein [Function unknown].	2.94813e-58

>NZ_AP022557.1|WP_033843397.1|1777379_1778468_-|Ger(x)C-family-spore-germination-protein
MRRGWLWIGALLLLGGCASSSRPIDEIQIIQEMGYDFENGRYTGTAVYPTFKQGPMTKPNLLTTTSPTMYDLIPRLSSKSPLPIEEGQLRLILFGKEFAKRGVTQITHSLARNNKVGSHLLLGVAKGSAKELLHITAKTTLSDTLYLPNLVEQNEQSMNLPKTNLHLFLYRYFSPGSDPFLPYFEKKGDFVKLEGLALFRDDNYVGHVSLRDAFLMKILLGETKNGVYQLKVGNRGKQGEDRVMLQNLWAKPKFEWKRDGSRHRLDVFVHIHASVRDYPSWFDPLMGKQLDNVKKKMENELEHNIERLFRYFQKKRIDPLGFGDFVRSVTRHWDQAAFYREYPDLDIRPHVTVDIVHTGIGE
>NZ_AP022557.1|WP_033843398.1|1776240_1777353_-|GerAB/ArcD/ProY-family-transporter
MKQPIPDRFLISPFFVFFVVHATQIGVGALSFQQPLMKAVGQDAWMVVLLAGLAAHLFIWLMYRLLSRAPFGGDIVSLHQHYLGRWFGGLLSVGVMCYYLLAALTVLQAYIEIIKVWVFPLMGTWQFSLIFLALTYYAVLGGFRVVVGLCVWGVVIPLATIFPMLFFPLEYAQYRNLLPVFDHSFGQLVSASKEMTLQYLGFEMLLMYYPFVKNAPSSQKWAHAANGFTTFIYLVIILISIVFYNQEQIQHLTWPTLTLAKIPEVPFIERMEYIVISIYVLVVFPIITLSVWAATRVVKQLFAVQQRRSLPVLLVILFIGTLLLQEKADIERISQWTAKLGLYLVAVYVPLLCISVWVVEKVKKTLQQKR
>NZ_AP022557.1|WP_033843399.1|1775399_1776071_-|7-cyano-7-deazaguanine-synthase-QueC
MKRKEEKAVVVFSGGQDSTTCLFWAKKQFGDVEAVTFDYGQRHRLEIEVASSIAAELGVRHTVLDLSLLGQLAPNALTRRDIAIEQKEGELPTTFVDGRNLLFLSFAAVLAKQRGARHMVTGVCETDFSGYPDCRDVFIKSLNVTLNLAMDYEFVIHTPLMWLTKAETWKLADELGALEFIRTKTLTCYNGVIADGCGECPACVLRKRGLEEYLREKAEVEVR
>NZ_AP022557.1|WP_033843400.1|1774965_1775403_-|6-carboxytetrahydropterin-synthase-QueD
MMHQLYPQVTHHYRYELNKDMHVAAAHFIPHKAAGSCANVHGHTYIVNVTIAGDELDESGFLVNFQTVKKLVHGKLDHTLLNDHNDWFDRHDPNRFPTTEVVARTIYETIQRYLDTLPHKPKCLQVFVRETPTSYVVYRPKAGER
>NZ_AP022557.1|WP_033843401.1|1774231_1774966_-|7-carboxy-7-deazaguanine-synthase-QueE
MARTIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYRCRWCDSAFTWDGSAKDEIEQLTADDIWRRLEAIGGRRFRHVTISGGNPLLIAALGELVALLHEKGVRVAVETQGSRWQDWLLDVDDVTLSPKPPSSGMDTDWAALDQIIERLQADRSRARRVSLKVVVFDDDDLSYAKEVHRRYPGVPFYLQTGNADVAASEVDALRVKLLSRLEWLVEQAAESEELADVHILPQLHTLLWGNKRGV
>NZ_AP022557.1|WP_081130697.1|1772343_1773717_-|IS1380-family-transposase
MKDFPIRFVLTDEAITPSAGLALVGYLLHRTKLDKRVNALRLPTVRREVHISHSDVIRSMIGLLATGKTDFDHIEAYRQDDIFSASMGIQHVPSSPTLRQRLDQLACLPMTEAIIWEESMRLLVRQHATLSPCWTKGKTTWLPLDVDGSPFDNSDTKKEGVSRTYKGFDGFTPLFAYAGKEGYIVHAELRPGKQHVQDNMPSFLTTAIRRARPLTSSRLLVRMDAGNDAEANVHVCLKEDVDFVIKRNLRRESKALWFQIASQKGRRIDDGQTEGVQTYELCLPQKVAIDGNTYTYVQVTQVTERTMERNGQLMLVPNYEVESYWVRLEGYEHVRMSDVLALYHDHATCEQFHSELKSDLDLERLPSGKMKTNAIVLVMGAFVYNLLRLIGQDLLSDPRHPLHHKVKRRRIKTIIQTVITMAGLLVRRSRQIWMKLTRRSGYSEPLLNVYQKWREAR
>NZ_AP022557.1|WP_172418595.1|1771304_1772201_-|hypothetical-protein
MDYQSIKITTKSKSISIHHGFREFIYNGKSIHELSCELGLNWSSVERWRQVHGLPKHSDKEKIIKQYGLEVWTNIMKKERYSASNRRNAEKIKGKSYEEIYGSNKATEIKNRISFANRGIKRSKVFRGNLSDRQKGHKNSNWKGGFYSGNAYKEIDRVYIKEYVLDTWNKYFIMEKNYTCESCGITTITCNGHHILSFTKIFEAVCFYLGKRNQLNTLSVIKEMHLFHKRNYRQIYKCLCPSCHRNIHKQQNYQVRVNEENQLIHLLTPYFSDPEPSLRRQEVAPFEEGAETIEITSE
>NZ_AP022557.1|WP_033844836.1|1770088_1770748_-|oxidoreductase
MERRTALLLGASGLVGGEVLKLLLQSDIYRQVTVLVRTPLPIKHEKLQQVVADFAQLESYERYFAVDDVFCCLGTTRKKAKTKQRFIQVDYEYTLRAAALAEKRRVKSFLTISSVGADPCSPFFYQRVKGEMEEALQRLSIPSLHIFRPSLLVGKRREFRLGEALAGWLFGRLPFLFVGKWKKYKPIDAHELALAMFYRALSAADGVHIYECDELARIS
>NZ_AP022557.1|WP_081897190.1|1769879_1770056_+|DUF2187-family-protein
MKKAKVGDIIEFKNGLRGIVEKVNENSVIVDLTYMKNYRELDLQERTVVNHKNYKIIE
>NZ_AP022557.1|WP_033843404.1|1768883_1769468_+|cell-wall-hydrolase
MKRGKAWVMALLCGTFFFAGHADAATIHTVKRGDTLWKIAKQYGVPLKQLKQKNRKGDLLYPGEQLVIPDAGITAAEKDLLARLVHAEAKGEPYAGKVAVATVVLNRVDHPDFPDTIRDVIYERSGGHYAFTPVANGTINEPADRESYRAVEEALAFRGLGNGSLYFYNPKTAKSNWLRSRPVTVVIGNHVFAK
>NZ_AP022557.1|WP_051985027.1|1780495_1782157_+|chemotaxis-protein
MSDLTKRRRAKQALKKATETAEWLRRSMDPTRPLEEQLDRLRALLDERLGQDEYFVVVDENGYGLIHTNRLREGRTFADPVGLAAARTNEPLLQVYERDTGEVLIDASCPLWTEPSGRRINLRLGRLMHRPYLPWVFASLVALPVAVGGGMAAARLPVWLAALAAMIAGAALSFFWERRLTTELRRWYRVARTASSGQLHAEVETAGKRNEFHQIAYEINKMILGIRTMITELGKAAKTVRDVSHEQQMEMRRLSESFDEIAAAVETFREGAKQQTDAVRQADDVIQQMVERVQGMRSAVERVVRQADEAWSSAAEGIRLMDETKTNMDAMQIGIGETTTLIDKAAKEAGRVHEMIAAIRTIAKQTNLLALNASIEAARAGEAGRGFSIVAQEVRKLAEDTNAFASEIFSSLDAMANALKEAVDAAQGSGRHVEKTKDSLWKTGETFTALGNMFAQLNGLLQQNEAYVNDITADGRRLSELMEGVRTVATEFSNMVHETSAGLEQQTLALHQLAREADALAAAARELDKMISRFHFEKTEKTAEVGDRPTSLQ
>NZ_AP022557.1|WP_033017661.1|1782221_1783262_-|membrane-protein
MRKKTEWAEAWQIAAVYVGTVIGAGFATGREIIEFFTRYGTAGTIGVAVSGALFTWGGARLMVMARRLGAASYDELNRYLFGKRLSPLVTFVMTCMVAGVTAVMIAGAGAVFEEQLGWPRQAGIALTLGAALTVMLLDRKGLFGVNVFVVPMMVLFSVTILLKMATAGHLCRPGATAADYSLKAMMAPFSYAAFNLAMAQAVLVPVAREAANERVVKRGAVLGGLLLTGLLLLNHTVLLSFPHHAGDEIPMAQVVRTFFAVLYWFYVVVIYGEIFTSVIGGLFGLERQARAWWPGGGKPLGVLLVLLFAAVSPFRYGELLSMVYPLFGYISICLLWLLWRRRMPKR
>NZ_AP022557.1|WP_033843395.1|1783579_1784338_-|FixH-family-protein
MKRFALACAATLIVLTAAACSDNNKRTETPAVLDVKMEIPDHIELNKPTKLACVVTYGGEKVDDASEVKFEVWKHGAGDRDMLKAKRDGSGRYSVTKTFTEAGTYSVVAHVTARDMHNMPKKDVVVGNPSQAAEKGESDSHPSGEADHQHGEAGHHHDNSVSMSLSSHSVTAGKPVTLAVRIMKDGKPLTKATVRFEIWQADNKHEFVETKEAGNGDYQAEVTFATPGTYSVKVHVEAASLHEHQVEQVMAH
>NZ_AP022557.1|WP_033017658.1|1784607_1786743_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MRCQACQQREATVFVNLQWNGEKKQLHLCHTCYEKQKQQLSIPMNFGFSPFSFDDWFAGHLAAANAQAAAPETAAKHPQRHGGGFLDQFGRNLTQMAKAGLIDPVIGRDKEIARVIEILNRRNKNNPVLIGEPGVGKTAIVEGLALKIAEGNVPEKLLNKEVYLLDVASLVANTGIRGQFEERMKRLIAELQERKNVILFIDEIHLLVGAGAAEGSMDAGNILKPALARGELQVVGATTLKEYRHIEKDAALERRFQPVIVNEPTVDEAIAILKGIQPKYEQFHHVRYTDEAIEACVKLAHRYIQDRFLPDKAIDLLDEAGSKANLHLGPTDEKQLQERLMQIAKEKEQAAKEENYELAAKLRDEELKLEKQLDQGVTQERPVVDAADIEQIIAEKTGIPVGKLQADEKEKMKHLEDNLAKKVIGQAEAVQKVAKAIRRSRAGLKAKHRPIGSFLFVGPTGVGKTELAKTLAEELFGTKDAMIRLDMSEYMEKHSVAKLIGSPPGYIGFEEAGQLTEKVRRHPYSIILLDEIEKAHPDVQHIFLQILEDGRLTDSQGRTVSFKDTVIIATSNAGVTDKKITVGFEKQSGGPSSVLDSLSAYFKPEFLNRFDAIIEFKPLEKAHLLEIVDLMLADVKAAMREQGIELDVTEAAKEKLAELGYHPAFGARPLRRVIQEHVEDNIADCLLDADQSVRAIRIDVKGDAIVAQIAS
>NZ_AP022557.1|WP_033017657.1|1786995_1787604_+|hypothetical-protein
MKEKFFYPLFIGVLLLAACERGHDPTPAPHHVGKEAVQGNEQKEKVKKEQKPLSLEEKFLPPHFLVNEFTAKATSRSIHLTMRYTLSEQLYQLLEQYRDYYFVIQYPEELSRVTHVDRSNAVKGPLPANGQLSYTITISSSWIDDIPKDLINRINHGDLRYNLLILDKERSPVHIFNDVQWYPSFDPNKGSSVISEDDGART
>NZ_AP022557.1|WP_033017655.1|1787778_1789473_-|M3-family-oligoendopeptidase
MKFSEFRYERPDIDQLQDAFQEALDAFRRAGSAAGQHEAMKRVNELRRRYSTMANLCHIRHTIDTNDEFYKKEQDFFDETGPIVKGLVNDYYRALVESPFRAELEKTWGAQLFALAETQLKTYAPAVMEDLQKENKLASEYTKLIASAKIMFEGEERTLAQLQPFVESPDRSVRKRASEARFSFFTDHEKELDELYDELVHVRTAIAEKLGFKNFVELGYARLGRTDYNAEMVANFRRQVKAHIVPLAVKLRERQRQRIQVDRLTYYDEPFMFPSGNPAPKGDAAWIVDNGRRMYEELSPETGAFFRYMVEHELMDLVAKKGKASGGYCTYIDDYQAPFIFSNFTGTSSDIDVLTHEAGHAFQVYESRHYDIPEYNWPTLEACEIHSMSMEFFTWPWMELFFAEDADKYRFAHLSDALLFLPYGVAVDEFQHAVYERPDMTPAERKKTWRDIENVYLPTKDYDGHDYLERGGFWQRQGHIYTDPFYYIDYTLAQVCAFQFWKRAEDDRAAAWRDYVALCRLGGSRPFTELVQSANLQSPFADGAVASVIGHIERWLDSVDDKAL
>NZ_AP022557.1|WP_082799314.1|1790280_1791705_+|amino-acid-permease
MGKQQKLGVWVLTALVVGNMVGSGIFMLPRSLAEAASPLGVMLAWLLTGTGVLMTALVFGNLAIRKPNLNGGPQIYAKELFPKGSNWSILSGFMSSWGYWVGNFAGNVAIITTFASYLSTFFPVLTSDHTVAMIGSFPLKLGNLLTFLVCTALLWGMHAIILRGVESAGKLNFVATAAKVLGFFLFIVIALFAFDKAVIGPLNAPRYDGDGQAISLLGQIKNAALATLWAFIGVESAMVFAARARKQADVKRATIAGLLIALAIYIGISFLVMGVLPQEKLIQSEKPLVDAIVAIVGPIGGYVLAGLGLISLLGSTLGWILLSAEVPYQAAKQGMFLPSFLKENDRRAPSFSLTLSNALAQLFIFSTISHSMAAAFDFVIYIATLAYLVPYLIASVFQLKLVITGETYQGERSRLTDGVVAAVASVYSVWVVIAGTADIKTFLFGLTLLASGLIFYPQVRKAAQHERQRQKRSA
>NZ_AP022557.1|WP_033017652.1|1791826_1793845_+|S9-family-peptidase
MNSEHETKRRGMTAEDLLRLRSVRDPHYAPDGTRVVFVEKSIDEEKQYRSHLSMWTEDGSVRPWTFGRWRDTKPRFSPTGEEIAFLSDRSGRAQLWRLPAHGGEARQLTFFKNGVRDYVWAPDGTFLIALTTIGDDETIADREEPEKKEAKPADPKPRVVERLYYKSDAAGFLDDKRPVLVRIDAATGKAEALTSREEEIGSFAMSPNGRTLAFVANRNEDPDTVFTRDIVLLDLESKAETNVTNGCGTFTSLAWSPDGTKLAAIGHDLAYLGATLHRLYVFEPERGTARVLTADWDVHLGDAMIGDMHADAKGPGPIWANDASGLYVTASERGRVNVFFIPLDGPVVPIIEGDFHVYGLAVHPNEQQAVAAISEPTVIGDLYAISFENGAKTRLTTVNEALENEVALADAEPFTYQSTDGSDIQGWIMKPPGLGEGEKAPLIVEIHGGPHAMYGLTFFHEFQLLVSHGYAVLFTNPRGSHGYGQAFVNAVRGDYGGMDYEDIMAGVDAAIRQFDFIDETRLGVTGGSYGGFMTNWIVGHTNRFKAAVTQRSISNWLSFSGVSDIGYFFTKWEVGCDMWEDAERLWHHSPLKYVKQMNTPLLILHSERDYRCPIEQAEQLFIALKQLGRETKFVRFPDANHDLSRTGNPMLRLERLRHIVEWFDRYLTKSLP
>NZ_AP022557.1|WP_172418596.1|1794175_1794745_-|phosphate-propanoyltransferase
MMIPVGVSNRHIHLSSEHMAALFGEGVELTVLKPLSQPGQFAANETVTVEGPKGKIENVRVLGPVRSLTQLEISKTDSFKLGVAPPVRLSGDIDGTPGITIHGPKGTVTVDKGVIIAKRHIHMTPKDAETFGVRDKQVVKVKTQGERALIFDEVIVRVSDDFALDMHIDTDEANAAGLKTGDYVELLPS
>NZ_AP022557.1|WP_033017703.1|1794920_1795382_-|MarR-family-transcriptional-regulator
MEQKGQALEQSLKLFIVLSRAYRAVSDQVNKSIHSFGVNPTEFAVLELLYHKGDQPLQQIGEKILLASGSITYVVDKLENKGLIVRRACERDRRVTYASITEEGRRFIERVFPEHAETIHDTVSALTAEEKEQAIALLKKLGYGAKHALTDRG

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Crispr_ID: NZ_AP022557_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_18

1934333-1934419

Orphan

Consensus_repeat	Method
GCAAAATGTCTGCGAGCTCAACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_18

>merge|NZ_AP022557|18|1934333-1934419|CRISPRCasFinder
GCAAAATGTCTGCGAGCTCAACGTTCGAGGAAGGGAAACCGTCCGACCGTTCCACTGTCCCTACGCAAAATGTCTGCGAGCTCACCG

>NZ_AP022557|18|18|1934333-1934419|CRISPRCasFinder
GCAAAATGTCTGCGAGCTCAACG	TTCGAGGAAGGGAAACCGTCCGACCGTTCCACTGTCCCTAC
GCAAAATGTCTGCGAGCTCACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_172418619.1\|1931027_1931768_-\|YjbA-family-protein	unknown	unknown	gnl\|CDD\|371975
NZ_AP022557.1\|WP_031405116.1\|1943434_1943614_-\|YjzC-family-protein	unknown	unknown	gnl\|CDD\|372942
NZ_AP022557.1\|WP_172418616.1\|1927193_1928843_-\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173869
NZ_AP022557.1\|WP_033843295.1\|1936374_1937115_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843291.1\|1943805_1944744_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|234835
NZ_AP022557.1\|WP_172418614.1\|1925120_1926143_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_AP022557.1\|WP_033843294.1\|1937252_1937441_+\|YjzD-family-protein	unknown	unknown	gnl\|CDD\|371396
NZ_AP022557.1\|WP_033018516.1\|1931853_1932060_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843296.1\|1935931_1936180_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418615.1\|1926139_1927069_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_AP022557.1\|WP_172418621.1\|1933074_1934313_-\|beta-ketoacyl-ACP-synthase-II	unknown	unknown	gnl\|CDD\|274452
NZ_AP022557.1\|WP_172418618.1\|1929996_1930983_+\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
NZ_AP022557.1\|WP_172418613.1\|1924037_1925099_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_AP022557.1\|WP_033843288.1\|1947861_1948926_-\|carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|183784
NZ_AP022557.1\|WP_033843292.1\|1940735_1943321_-\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NZ_AP022557.1\|WP_033843290.1\|1944740_1947869_-\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|237215
NZ_AP022557.1\|WP_172418622.1\|1937819_1939940_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_AP022557.1\|WP_172418620.1\|1932153_1932942_-\|DUF2268-domain-containing-protein	unknown	unknown	gnl\|CDD\|370782
NZ_AP022557.1\|WP_172418617.1\|1929283_1929661_+\|DUF3899-domain-containing-protein	unknown	unknown	gnl\|CDD\|372441
NZ_AP022557.1\|WP_033843293.1\|1940030_1940603_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_172418619.1\|1931027_1931768_-\|YjbA-family-protein	gnl\|CDD\|371975	pfam12227, DUF3603, Protein of unknown function (DUF3603). This protein is found in bacteria and eukaryotes. Proteins in this family are about 250 amino acids in length.	1.70766e-144
NZ_AP022557.1\|WP_031405116.1\|1943434_1943614_-\|YjzC-family-protein	gnl\|CDD\|372942	pfam14168, YjzC, YjzC-like protein. The YjzC-like protein family includes the B. subtilis YjzC protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	2.43268e-27
NZ_AP022557.1\|WP_172418616.1\|1927193_1928843_-\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173869	cd08504, PBP2_OppA, The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding component of an ATP-binding cassette (ABC)-type oligopeptide transport system comprised of 5 subunits. The transport system OppABCDEF contains two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_AP022557.1\|WP_033843293.1\|1940030_1940603_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.53914e-13
NZ_AP022557.1\|WP_033843291.1\|1943805_1944744_-\|ornithine-carbamoyltransferase	gnl\|CDD\|234835	PRK00779, PRK00779, ornithine carbamoyltransferase; Provisional.	0
NZ_AP022557.1\|WP_172418614.1\|1925120_1926143_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.53044e-105
NZ_AP022557.1\|WP_033843294.1\|1937252_1937441_+\|YjzD-family-protein	gnl\|CDD\|371396	pfam11151, DUF2929, Protein of unknown function (DUF2929). This family of proteins with unknown function appears to be restricted to Firmicutes.	2.56813e-15
NZ_AP022557.1\|WP_172418622.1\|1937819_1939940_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	3.70448e-77
NZ_AP022557.1\|WP_172418621.1\|1933074_1934313_-\|beta-ketoacyl-ACP-synthase-II	gnl\|CDD\|274452	TIGR03150, fabF, beta-ketoacyl-acyl-carrier-protein synthase II. 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis].	0
NZ_AP022557.1\|WP_172418618.1\|1929996_1930983_+\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	0
NZ_AP022557.1\|WP_172418613.1\|1924037_1925099_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	0
NZ_AP022557.1\|WP_033843288.1\|1947861_1948926_-\|carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|183784	PRK12838, PRK12838, carbamoyl phosphate synthase small subunit; Reviewed.	0
NZ_AP022557.1\|WP_033843292.1\|1940735_1943321_-\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_AP022557.1\|WP_172418615.1\|1926139_1927069_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.51004e-113
NZ_AP022557.1\|WP_172418620.1\|1932153_1932942_-\|DUF2268-domain-containing-protein	gnl\|CDD\|370782	pfam10026, DUF2268, Predicted Zn-dependent protease (DUF2268). This domain, found in various hypothetical bacterial proteins, as well as predicted zinc dependent proteases, has no known function.	2.08761e-74
NZ_AP022557.1\|WP_172418617.1\|1929283_1929661_+\|DUF3899-domain-containing-protein	gnl\|CDD\|372441	pfam13038, DUF3899, Domain of unknown function (DUF3899). Putative Tryptophanyl-tRNA synthetase.	1.05589e-14
NZ_AP022557.1\|WP_033843290.1\|1944740_1947869_-\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|237215	PRK12815, carB, carbamoyl phosphate synthase large subunit; Reviewed.	0

>NZ_AP022557.1|WP_172418621.1|1933074_1934313_-|beta-ketoacyl-ACP-synthase-II
MEKKRVVVTGLGAVTPLGNDVETTWKNIVAGQSGIDIVTRVNPDDFPAKVAAEVKDFDPSLFVDRREARKMDRFTQFAVAAALMAVKDARLEINEQNAERIGVWIGSGIGGMETFEQQFEIFQQRGYRRVSPFFVPMMIPDMAAGQVSILLGTKGINSCTVTACATGANSIGDAFKVIQRGDADVMIAGGTEAPITKMSFAGFCANTALSTNPDPKTASRPFDKHRDGFVMGEGAGIVVLEELEHALRRGAKIYAEIVGYGATADAYHITAPAPGGEGGVRAMRQALQDAGLKPEDIDYINAHGTSTEYNDKYETAAIKEVFGDHAYRLAVSSTKSMTGHLLGATGAVEAIFSVLAIRDGVIPPTINYETPDPECDLDYVPNEARKQEVRAVLSNSFGFGGHNATLIFKNYR
>NZ_AP022557.1|WP_172418620.1|1932153_1932942_-|DUF2268-domain-containing-protein
MGLLPTDRWLEEDEGDPFRLCARLVPFFAKASARDIFSYLRRYGMYRSAQQAARLLPRMREQRLWARVGRIYERQRSAWKGPDVPVFLLPADDRNGKMKREFQGKGGVAFADKLFFFLLPDHRDEEIAALVVHEYNHVCRLKRLPNDGRDATLLDAVVMEGLAEHAVAETVGAEQCAGWTKYYTDREMERFWRRYIVPNQHLPVSHPHTSRILYGFGWHPKMGGYAVGYAIVRRCLERGHSLAQLMAMEAKEMAALAGFVVE
>NZ_AP022557.1|WP_033018516.1|1931853_1932060_-|hypothetical-protein
MVRLFFYLVGFGFSVVGGMMAIAYLNLLTPERGFCDYWVYIARRPECYLLPIGLLFIWGSLSFPSRGS
>NZ_AP022557.1|WP_172418619.1|1931027_1931768_-|YjbA-family-protein
MLCLHDIWVNWFEGEENGYNVCHFHEWRKDDQIELLDQVPLLKVTPALFHYIENSLSDLPKPLLDDVYQKAYVRKNHERIPLDYCFIVTDGAGILAVDTIGYHIPIRKSRLIPRQEQLVYEMAAEAEERDYPLPEYNKEYHILSPAPELMWGLTRKERQLKQLLFMALDQLYSTKNGAEVRYWYTEWAPEKYADIQKMSFEEAWTRLYEETKHGWSKRHEQLCEHLIKGQPFFEKLWEMEQEPKVN
>NZ_AP022557.1|WP_172418618.1|1929996_1930983_+|tryptophan--tRNA-ligase
MKTIFSGIQPSGVITLGNYIGALRQFVELQHEYNCYFCIVDQHAITVPQDPDQLRQNIRRLAALYLAVGIDPAQATLFIQSEVPAHAQAAWMLQCLVYIGELERMTQFKEKSAGKEAVSAGLLTYPPLMAADILLYNTDIVPVGDDQKQHIELTRDLAERFNKRYGELFTIPEARIPKVGARIMSLVEPTKKMSKSDPNPKAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGISNLLHIYSTLSGQPIEELERQYEGKGYGVFKADLAQVVIETLRPIQERYHQWMESEELDRVLDEGAEKANRVAAEMVRKMEQAMGLGRRR
>NZ_AP022557.1|WP_172418617.1|1929283_1929661_+|DUF3899-domain-containing-protein
MKQTAVRTGWLIAAMMAAGALIVAWQGTWTGVAFINATFLLSLVPLSLGGLLFVYERGFFSGFAYGFQKWRKSAGTKAERYLEEAAAEQEFAQPPGPRRFAVTYPLLLSGLLLFLAMIAAGYAVQ
>NZ_AP022557.1|WP_172418616.1|1927193_1928843_-|peptide-ABC-transporter-substrate-binding-protein
MKKRFSFFLVLLLALSTFLAACGGKDNNNAQSGKGDEKPAAKKEQVLNLLESQEIPSLDSALATDQVSFIVLNNVMEGLYRLGKDNKPVPGVAESYEVSNDGKTYTFKLRKDAKWSNGDPVTAHDFEFAWKRVLDPKTKSEYAYIMYDIKNAEEANTGRVPLDQVGVKALDNYTLKVELKNAVPYFVGLTAFGTFMPQNEKFVKAQGEKYGLEANTTLYNGPFVLSEWKHEQGWVYTKNPNYWDKDTVKLEKVNVKVVKDTATAVNLYETKQADRVGLTAEFVDKYKNDKNFHTKLDPSLYWLRMNTKKEPLNNVNARKAIAMAIDTQAMVDTLLNNGSIPAKFAVPKDFVTGPDGKDFRDVNGDLVNYNPDEAKKLWEQAKKELGKDKFTVELLNYDTDSAKKIGEYVKEQLEKNLPGLTINIKQQPFAQKLKLESNMQYDLSFSGWGPDYQDPMTFLQLWTSTSPHNETGWSNAEYDKLIKDAQTTLANDLQARWDAMLKAEKIVFEGMPIAPLYQRGAAYVQREYVKDFVTHTFGADYSLKWAYVE
>NZ_AP022557.1|WP_172418615.1|1926139_1927069_-|ABC-transporter-permease
MARYTLQRFAYMVVTLFIIATLTFFLMKLLPGSPLQNQEKLTPEQKALILKEYGLDKPVPVQYMLYLGNLLKGDLGVSFQYDNRPVTELISDRIGPSAQLGFQAIVFGTIVGLILGIVAAIRHNRWEDYTATVIAVLGASIPSFVLGGFLQYFIAVKWQLLPVAFWEGFKYTILPTLALSVGVIASIARFMRTEMLEVLSSDYILTARAKGISQAGVILKHAIRNSLIPVITILGPMTVNLMTGTLVIEKLFAVPGLGEQFVRSIELNDYPVIMGTTLFYSALLILAVFIVDVLYGVVDPRIRLAGGKK
>NZ_AP022557.1|WP_172418614.1|1925120_1926143_-|ABC-transporter-permease
MMAKQQYEQLSPEWFQPAPPNVGEQEKINRPSLTFWQDAWLRLRENKAAIVGLVMIIILTLMAIIAPMVSDRTYKDQNLRHAKLPPKIPVLEHIHWLPFDGRDANGVDVYKQRGVKEYYWFGTDDLGRDLWVRTWYGTRISLYIGLLAALIDLLIGIAYGGISGYYGGRVDNVMQRIIEILNGIPYLIVVILFILIFEPGIISITLAMVITGWTTMARIVRGQVLKLKNMEYVLAARTLGAPTSRLIFKHLIPNVIGPIIITTMFTIPSAIFTEAFLSFIGLGIRPPEASLGSLVNDGYKSIQTYPHLMIIPAVVISLLILSFNLVADGIRDALDPKMRK
>NZ_AP022557.1|WP_172418613.1|1924037_1925099_-|ABC-transporter-ATP-binding-protein
MEKILQVNDLHVSFDIHAGEVQAVRGVTFDLYKGETLAIVGESGSGKSVTSKALMRLLPTPPSRIKRGEILFEGKDLTKLSEKDMQSIRGAKISMIFQDPMTSLNPTMTIGKQIMEAILKHQKLSKDEARKRAIELLQLVGIKNAELRMKQYPHQFSGGMRQRVVIAIALACNPKILIADEPTTALDVTIQAQILELMKDIQKKLGMSIIFITHDLGVVANMADRVAVMYAGKIVEIGTVDEIFYNPKHPYTWGLLASMPSLDHKDTELYSIPGSPPDLLNPPKGDAFAPRNPYALKIDYELEPPMFQVSDTHYAATWLLHEMAPNVEPPAIVRERMKRFAEIVARKGGTPRG
>NZ_AP022557.1|WP_033843296.1|1935931_1936180_+|hypothetical-protein
MADSPAPKPSNKATDRFSRLMFQPFPPRRAERQEETGENEALPLPDIDWVKLFDQVGALTDSLQQLKPLMRKMTSLVELFKK
>NZ_AP022557.1|WP_033843295.1|1936374_1937115_-|hypothetical-protein
METMAGQQRFFQLDEQWCIVHIPERPNGFALFVIGDGDHFVNERTSFWLEHPTRRQWLEEWLERGYTVFSSHLYGRHWGSPKAVRLARQLVYSVLKSEIVNSRIYLVAEGMGALIASQLLSVMPRQMRAVAMINPCLDVRAQLDHERDHPLMYRRMVKEIAFAYGMKEEEVPEAVPALFLSPHDVPVIVWQLSGVSPYPFALHGRRYEQWMKATNRHVRIIDELPEKRPQLAAQIARFFHQHNELP
>NZ_AP022557.1|WP_033843294.1|1937252_1937441_+|YjzD-family-protein
MRLFWTFFWTFLLMQMATYVMSSMQGISYDFATGALLGVIVTVLIIVVAALIPDEPAGNHHH
>NZ_AP022557.1|WP_172418622.1|1937819_1939940_-|MMPL-family-transporter
MSRWLRAVTDWVATKKGMWWTLALWLAAIGALAALAPNVKQYEASSIETVPKEAQSMVAQAKVDRYFQADDGIPAIFVFRSEKEPVSKDALQRLLMQIQQQHQEAIEKLVPVASLPPQAAASFFAKDGKTVVVPVTYKGSLESKEIEALNKDIRQLVNNKSAMKLYITGPAGIAADTLALFSRADVVLLLSTVGLILVLLIVIYRSPLLALIPLVVAGMVYGVVGQLLGLLGRGGLVISKQTVSIMSILLFAAVTDYSLFIFSRYREELKRHEDKWEAMRQAMRETGLPVLFSGGTVLAAMLVLFFAKLGDYRNFAPTFALAMAVIMIASVTLIPALFTLFGRKAFWPNIPRVGENKARGRRTLWETVARFVAAKPRLTVAVIGALLVVLASHSPFLRYEYDLIKSFPQDMPSRQGYELLEKHFAKGELAPTTVLYEGKEALSPQQLARLQDELGKQPLVSEVRPAGTADDGRVVSFTLTFRENPYEAKTLDALERIIERKETILNESGFDGRLYFAGETAAKVDERALNHRDTAVIVSLETVLIFLLLFALTKSVKRSLYMIGTILVSFASALGLGIWLADGLFDINAVSDRVPIYAFVFLVALGIDYNIILVSRFQEEWRTHSVKGAVERAVAHTGGVISSAGLILAATFAVLMTQPVQLLFVFGFLVAIGILLDTFLIRGMLLPGLIVWLEKERTERPQPGNG
>NZ_AP022557.1|WP_033843293.1|1940030_1940603_-|TetR/AcrR-family-transcriptional-regulator
MARERKISLTELFAQTKQLLLEHGYEGFTFGLLADRLGVARSAIYKYFENKEELITAYMVDEMEQVFEKLTRIHDFPAFEEQFRFLLDLILYHDDLHEMIAIGKKIPETHPKVKENKRRLAQFHERMYDEVQPVIQRGKREGKMKPHLPDRVILGYIFQSAAVPHFPGISLAEWAESIREIIMHGVLNGN
>NZ_AP022557.1|WP_033843292.1|1940735_1943321_-|ATP-dependent-chaperone-ClpB
MDASRLTEKLQEAFMAAQSLAKERHHQQLDVEHLLLALFEQEGGLAPRLLELSGADKEKAADWLRHQLRQKPEVHGADGQLYVAPALARLLEEAEAEAKRMQDEYISVEHVLLALPRGAEPVARQLAPFGVTREALLAALTKVRGNQRVTSPNPEATYEALTKYGRDLVAEARAGKIDPVIGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPEGLKDKTIFALDMSALVAGAKFRGEFEERLKAVLNEIKKSDGRIILFIDELHTIVGAGRAEGAMDAGNMLKPMLARGELRCIGATTLDEYRQYIEKDPALERRFQQVLVQEPSVEDTISILRGLKERYEVHHGVKIHDRALVAAAVLSDRYISDRFLPDKAIDLVDEACATIRTEMDSMPSELDEVMRRVMQLEIEEAALSKETDEASRARLAALQKELADLREKANAMKAKWQQEKEALDRVRRLREALERAKRELEEAENDYDLNKAAELRHGRIPQLEKQLKQLEQEISEQSEGKLLREEVTEEEIAEIVSRWTGIPLTRLVEGEREKLLRLHEWLHRRVIGQEEAVGLVADAILRARAGLKDPHRPIGSFLFLGPTGVGKTELAKALAEALFDSEEQLIRLDMSEYMEKHAVSRLIGAPPGYVGYEEGGQLTEAVRRKPYSVLLFDEIEKAHPDVFNILLQLLDDGRLTDSHGRTVDFKNTVVIMTSNIGSPLLLENNQGGIDEGTRNEVLGQLRAHFRPEFLNRIDDIVLFKPLSMNEVKGIVDKFARELSGRLADRHIELALTEAAKQYIAEAGFDPVYGARPLKRFMQKQIETPLAKALIAGQVKEHSAVTVDVEDGTIIIRPSS
>NZ_AP022557.1|WP_031405116.1|1943434_1943614_-|YjzC-family-protein
MGQPRHFKPGDKAPNNGIYIEIGETGDNVKHPKKLKLKAGDTFPETSNHNRHWTYLRKP
>NZ_AP022557.1|WP_033843291.1|1943805_1944744_-|ornithine-carbamoyltransferase
MNAVMSLKGRDVLTLLDFSTDEIFDLLALAADLKAKQKAGIPYTPLVGKTMAMIFEKPSTRTRVSFEVGMIQLGGQALYLNGNDLQLGRGETIADTARVLSQYVDVMMIRTFAHEKVEELAEYASVPVINGLTDDDHPCQALADLLTIYEVKKTFQGLKLAYVGDGNNVANALLAAAAKVGMDVAIACPPGYEPKAAYVEAARQIGEKTGAAVTVTHDPLEAVAGADAIYTDVWTSMGQESESAERLRVFQPYQVNEELVKAAKPDYLFLHCLPAHRGEEVTAGVIDGPNSFVFEQAGNRLHAQKAILVSIL
>NZ_AP022557.1|WP_033843290.1|1944740_1947869_-|carbamoyl-phosphate-synthase-large-subunit
MPKDSSLQSILLIGSGPIVIGQAAEFDYSGTQACIALKEEGYRVILVNNNPATIMTDDVHADAVYFEPLTVDAVEAIIAKERPDGLLATFGGQTGLNLAFQLHEAGVLETYGVRLLGTPIEAIQRGEDREAFRALMQELGEPVPESEIVTSVEEAVAFAEKIGFPIIIRPAYTLGGTGGGIADNMEQFIALVEKGLAESPIRQCLIERSVAGFKEIEYEVMRDQSNTCITVCNMENVDPVGIHTGDSIVVAPSQTLTDEEYQMLRSSAVKIISALGIIGGCNIQFALDPNSKQYYLIEVNPRVSRSSALASKATGYPIARIAAKLAVGYTLAELVNPVTKTTYASFEPALDYVVVKFPRLPFDKFPHADRKLGTQMKATGEVMAIDRNMERAFQKAVQSLEGKNNGLFWPELAAKTNDELKQLLVDKDDRRFFAILELLRRGVTVEDIHTWTKIDRFFLRSFERLVALEKQATAASIDTIDEATFRFLKEKGCSDAFLAETWGVTELDVRRKRKELGIVPSYKMVDTCAAEFHSETDYYYSTYFGEDERKKASGKEKVLIIGAGPIRIGQGIEFDYSSVHSVFALQQEGYETVMINNNPETVSTDFAVADRLYFEPLTLESVLDVMEAEQIKHIIVQFGGQTAINLVKGLEEAGVPLLGVTYEIIDQLEDRDRFYQLLEELDIPHVPGLMANNAEELVAKAAAIGYPVLLRPSYVIGGRGMFIVRNEIQLAALIEQGELTYPILIDAYLDGKEAEADIVTDGTDLLLPTIIEHVEKAGVHSGDSYAWLPAQTLTDEEKAKIIDYAGRIANKLGFKGIMNIQYVIADGHVYVLEVNPRASRTVPIVSKTTGVPLAQIATKLLLGKSLVDMVDENMRKLAVMPYVVLKYPVFSTYKLPGVDPTVGPEMKSTGEGISIAATKEEAAYKAFYAYLQKKANANEMYVIGGIDEALAAEIEAKQLVMVSELPFAEWVKRDTALAVIDLGKEEGEAPKRMAALSRQLLVFTEPETLKLFLQALAVDQLDVQPIYSWLEKKKQAEQAVIL
>NZ_AP022557.1|WP_033843288.1|1947861_1948926_-|carbamoyl-phosphate-synthase-small-subunit
MKAYLHLASGKTFSGELAVPLAEKVSGEIVFFTGMTGYQEVLTDPSYKNQMIVFTYPLIGNYGINEEDFESKRPHVEAVIVYEASREGFHYGAKYSLAEYLRHWNIPLLTHVDTRALVKEIRTEGTMMTELSLSSVPSVFREEAAFPVRAVSTKRMETYGRGGPHIVLLDFGYKKSILRSLVARGCQVTVVPHDTTPEAIEALKPDGLVLSNGPGDPKQLRHQLPVIRQLIDRYPTLAICLGHQLVALAYGADTEKLRFGHRGANQPVWDAVKQNVVMTSQNHSYVVKEDSLAATPLAIRFINVNDGSIEGMIHRHKPILSVQYHPEAHPGPHDTGYIFDEFLQTVAKGEKVYA

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Crispr_ID: NZ_AP022557_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_19

2304367-2304459

Orphan

Consensus_repeat	Method
CCTGCTATTCAATGTAATTGACAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_19

>merge|NZ_AP022557|19|2304367-2304459|CRISPRCasFinder
CCTGCTATTCAATGTAATTGACAAGGCAAAACAAAGCGTTGGTCATCGTCTAGCTTGATCACCGCTACCCTGCTATTCAATGTAATTGACGAG

>NZ_AP022557|19|19|2304367-2304459|CRISPRCasFinder
CCTGCTATTCAATGTAATTGACAAG	GCAAAACAAAGCGTTGGTCATCGTCTAGCTTGATCACCGCTAC
CCTGCTATTCAATGTAATTGACGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033020429.1\|2295906_2296677_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213186
NZ_AP022557.1\|WP_033020433.1\|2300379_2301552_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380556
NZ_AP022557.1\|WP_033020435.1\|2301706_2302354_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_AP022557.1\|WP_033020452.1\|2312193_2312421_-\|YuzF-family-protein	unknown	unknown	gnl\|CDD\|371265
NZ_AP022557.1\|WP_033020442.1\|2305172_2305952_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|131358
NZ_AP022557.1\|WP_033020443.1\|2306049_2306967_-\|2,4-dihydroxyhept-2-ene-1,7-dioic-acid-aldolase	unknown	unknown	gnl\|CDD\|131366
NZ_AP022557.1\|WP_033020439.1\|2303918_2304311_-\|5-carboxymethyl-2-hydroxymuconate-Delta-isomerase	unknown	unknown	gnl\|CDD\|376972
NZ_AP022557.1\|WP_033844772.1\|2294517_2294985_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|214900
NZ_AP022557.1\|WP_033843116.1\|2293748_2294312_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NZ_AP022557.1\|WP_033020432.1\|2299436_2300318_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
NZ_AP022557.1\|WP_081130697.1\|2297109_2298483_+\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_AP022557.1\|WP_033020445.1\|2307117_2308101_-\|3,4-dihydroxyphenylacetate-2,3-dioxygenase	unknown	unknown	gnl\|CDD\|213698
NZ_AP022557.1\|WP_033020454.1\|2313028_2314393_-\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|225723
NZ_AP022557.1\|WP_033020437.1\|2302393_2303905_-\|5-carboxymethyl-2-hydroxymuconate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143412
NZ_AP022557.1\|WP_131385718.1\|2308134_2308422_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033020426.1\|2295181_2295907_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223487
NZ_AP022557.1\|WP_033020446.1\|2308507_2309986_-\|4-hydroxyphenylacetate-3-monooxygenase,-oxygenase-component	unknown	unknown	gnl\|CDD\|131362
NZ_AP022557.1\|WP_033020456.1\|2314511_2315687_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_AP022557.1\|WP_033020450.1\|2310208_2311132_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_AP022557.1\|WP_033020451.1\|2311276_2312176_-\|manganese-catalase-family-protein	unknown	unknown	gnl\|CDD\|226076

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033020429.1\|2295906_2296677_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	6.45901e-122
NZ_AP022557.1\|WP_033020433.1\|2300379_2301552_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380556	cd06333, PBP1_ABC_RPA1789-like, type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, RPA1791-1793), involved in active transport of lignin-derived aromatic substrates, and its close homologs. This group includes RPA1789 (CouP) from Rhodopseudomonas palustris and its close homologs in other bacteria. RPA1789 (CouP) is the periplasmic binding-protein component of an ABC system (CouPSTU; RPA1789, RPA1791-1793) that is involved in the active transport of lignin-derived aromatic substrates. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).	5.33425e-157
NZ_AP022557.1\|WP_033020435.1\|2301706_2302354_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.06004e-41
NZ_AP022557.1\|WP_033020452.1\|2312193_2312421_-\|YuzF-family-protein	gnl\|CDD\|371265	pfam10842, DUF2642, Protein of unknown function (DUF2642). This family of proteins with unknown function appear to be restricted to Bacillus spp.	2.32036e-23
NZ_AP022557.1\|WP_033020442.1\|2305172_2305952_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|131358	TIGR02305, HpaG-N-term, 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit. This model represents one of two subunits/domains of the bifunctional isomerase/decarboxylase involved in 4-hydroxyphenylacetate degradation. In E. coli and some other species this enzyme is encoded by a single polypeptide containing both this domain and the closely related C-terminal domain (TIGR02303). In other species such as Pasteurella multocida these domains are found as two separate proteins (usually as tandem genes). Together, these domains carry out the decarboxylation of 5-oxopent-3-ene-1,2,5-tricarboxylic acid (OPET) to 2-hydroxy-2,4-diene-1,7-dioate (HHDD) and the subsequent isomerization to 2-oxohept-3-ene-1,7-dioate (OHED).	4.34855e-77
NZ_AP022557.1\|WP_033020443.1\|2306049_2306967_-\|2,4-dihydroxyhept-2-ene-1,7-dioic-acid-aldolase	gnl\|CDD\|131366	TIGR02313, dihydrodipicolinate_synthase, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase. This model represents a subset of the DapA (dihydrodipicolinate synthase) family which has apparently evolved a separate function. The product of DapA, dihydrodipicolinate, results from the non-enzymatic cyclization and dehydration of 6-amino-2,4-dihydroxyhept-2-ene-1,7-dioic acid, which is different from the substrate of this reaction only in the presence of the amino group. In the absence of this amino group, and running the reaction in the opposite direction, the reaction corresponds to the HpaI aldolase component of the 4-hydroxyphenylacetic acid catabolism pathway (see TIGR02311). At present, this variant of DapA is found only in Oceanobacillus iheyensis HTE831 and Thermus thermophilus HB27. In both of these cases, one or more other DapA genes can be found and the one identified by this model is part of an operon for 4-hydroxyphenylacetic acid catabolism.	7.8264e-160
NZ_AP022557.1\|WP_033020439.1\|2303918_2304311_-\|5-carboxymethyl-2-hydroxymuconate-Delta-isomerase	gnl\|CDD\|376972	pfam02962, CHMI, 5-carboxymethyl-2-hydroxymuconate isomerase.	7.84484e-77
NZ_AP022557.1\|WP_033844772.1\|2294517_2294985_-\|flavin-reductase-family-protein	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	5.68151e-51
NZ_AP022557.1\|WP_033843116.1\|2293748_2294312_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	2.79553e-27
NZ_AP022557.1\|WP_033020432.1\|2299436_2300318_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	3.9238e-70
NZ_AP022557.1\|WP_081130697.1\|2297109_2298483_+\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.25216e-16
NZ_AP022557.1\|WP_033020445.1\|2307117_2308101_-\|3,4-dihydroxyphenylacetate-2,3-dioxygenase	gnl\|CDD\|213698	TIGR02295, Substrate_Complex_Of_Homoprotocatechuate, 3,4-dihydroxyphenylacetate 2,3-dioxygenase. This enzyme catalyzes the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate. 4-hydroxyphenylacetate arises from the degradation of tyrosine. The substrate, 3,4-dihydroxyphenylacetate (homoprotocatechuate) arises from the action of a hydroxylase on 4-hydroxyphenylacetate. The aromatic ring is opened by this dioxygenase exo to the 3,4-diol resulting in 2-hydroxy-5-carboxymethylmuconate semialdehyde. The enzyme from Bacillus brevis contains manganese.	1.09244e-154
NZ_AP022557.1\|WP_033020454.1\|2313028_2314393_-\|PepSY-domain-containing-protein	gnl\|CDD\|225723	COG3182, PiuB, Uncharacterized iron-regulated membrane protein [Function unknown].	1.58808e-131
NZ_AP022557.1\|WP_033020437.1\|2302393_2303905_-\|5-carboxymethyl-2-hydroxymuconate-semialdehyde-dehydrogenase	gnl\|CDD\|143412	cd07093, ALDH_F8_HMSADH, Human aldehyde dehydrogenase family 8 member A1-like. In humans, the aldehyde dehydrogenase family 8 member A1 (ALDH8A1) protein functions to convert 9-cis-retinal to 9-cis-retinoic acid and has a preference for NAD+. Also included in this CD is the 2-hydroxymuconic semialdehyde dehydrogenase (HMSADH) which catalyzes the conversion of 2-hydroxymuconic semialdehyde to 4-oxalocrotonate, a step in the meta cleavage pathway of aromatic hydrocarbons in bacteria. Such HMSADHs seen here are: XylG of the TOL plasmid pWW0 of Pseudomonas putida, TomC of Burkholderia cepacia G4, and AphC of Comamonas testosterone.	0
NZ_AP022557.1\|WP_033020426.1\|2295181_2295907_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	8.53038e-112
NZ_AP022557.1\|WP_033020446.1\|2308507_2309986_-\|4-hydroxyphenylacetate-3-monooxygenase,-oxygenase-component	gnl\|CDD\|131362	TIGR02309, 4-hydroxyphenylacetate_3-monooxygenase, 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component. This gene for this monooxygenase is found within apparent operons for the degradation of 4-hydroxyphenylacetic acid in Deinococcus, Thermus and Oceanobacillus. Phylogenetic trees support inclusion of the Bacillus halodurans sequence above trusted although the complete 4-hydroxyphenylacetic acid degradation pathway may not exist in that organism. Generally, this enzyme acts with the assistance of a small flavin reductase domain protein (HpaC) to provide the cycle the flavin reductant for the reaction. This family of sequences is a member of a larger subfamily of monooxygenases (pfam03241).	0
NZ_AP022557.1\|WP_033020456.1\|2314511_2315687_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.80924e-21
NZ_AP022557.1\|WP_033020450.1\|2310208_2311132_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.1329e-49
NZ_AP022557.1\|WP_033020451.1\|2311276_2312176_-\|manganese-catalase-family-protein	gnl\|CDD\|226076	COG3546, COG3546, Mn-containing catalase [Inorganic ion transport and metabolism].	1.01771e-104

>NZ_AP022557.1|WP_033020439.1|2303918_2304311_-|5-carboxymethyl-2-hydroxymuconate-Delta-isomerase
MPHFVLEYTANLGEEADIRGLLEKVHRVLIKRSDWFPVGGIRSRAIRLDEYYVADGAEDDAFVHGTLKIGAGRPEQVKKEVGDELFAVMKDHFAPLFAKRYLALSLELYEFSEAGTYKHNNIHARYRAQR
>NZ_AP022557.1|WP_033020437.1|2302393_2303905_-|5-carboxymethyl-2-hydroxymuconate-semialdehyde-dehydrogenase
MAVQPKVLHYINGQFVEGAAGLYFTNINPFTNEPINEVAEGRKEDIDAAVRAAKEAFDHGPWRTMPVEQRLRYLFRIAELIEQRADDIAYLEALDTGIPISQAKKQAARAAENFRFYAEMVKTRLVGEAYHVHGQFVNYTVHKPVGVAGLITPWNTPFMLETWKVAPALATGNTVVLKPAEWSPLTANQLAEIIDEAGLPRGVFNVVHGFGETAGAALVAHPDVRLISFTGETTTGMDIIRNSAATLKKTSMELGGKSPLIVFADADLERALDAAVWGVFSLNGERCTANSRLLLEQAIYDEFVARLKERVDRIAIGDPMNPATELGPLIHRDHWERVNRYIDIAKQEGVDVYAPGVPNGLENGNFVPPTLLLNCHNGMKVAQEEIFGPVMAVMSFADEEEAIRLANDVKYGLAAYVWTNDLKRGHRVAQAIESGMAWVNSPNVRDLRIPFGGTKYSGIGREGGHYSFDFYTEVQVVHVAVGDPPIPAFGKGGKRTALSAEQA
>NZ_AP022557.1|WP_033020435.1|2301706_2302354_-|GntR-family-transcriptional-regulator
MGTKAKNKTQLAYEYMLSRIESGVYGPGYRVVIDQIARELGLSSIPVREAIRQLEAEGLVEFKPYAGAVVSTINENEYVETLSVLAVLEGYATALGSANLKKEAINELERLNERMERALEELELERFSELNYEFHALIYAHCGNAYLEEQIKQIWQRMRRIRLYGFTFVPQRAKASIEEHREIIRLLREQAPAHDIEQYVRQHKLNTAEAFKQRR
>NZ_AP022557.1|WP_033020433.1|2300379_2301552_-|ABC-transporter-substrate-binding-protein
MKRRMSLFMTALLLVLLVACGKTTTSGNGGDEIKIGAIFSASGGAAPLGKPEMETVKMLVKQWNEQGGIDGKKIKLIAYDDKSDQNEAVLSAKKLIEQDNVTAIIGGTISGNSLAMIPQIEKAGIPYISLAASKQIVNPSDGSSRHWTFKTAQGDNIVIQKLLGFLKEKRWLNVAWLNVANAYGTSGHEEFVHYAPEYGVKAVIEEEFEATVDDAKAMLTKVKKANPQAIIVWGTAQESAVVTKNIRQLGIAAPIVESHGIGTKSFIDLAGEAANDVWFPAGRILVADQLPDSDPQKETLLKYKQDFEKAYGYAPTTFGGHAWDAFHLLANAIKEGGTEKEKIRSALENTRKFIGISGVFHMSKDDHTGLDADSLVMVQIQDGKFVLAEQ
>NZ_AP022557.1|WP_033020432.1|2299436_2300318_-|branched-chain-amino-acid-ABC-transporter-permease
MEAWSQFVQLLFSGLTVGSIYALVALGFVITYSVTGILNLAQGDFAMLGALFCVTLVNDGVPFVLAIGLSIVAVMAIGALFERLAIQPARRSPVAVLIIITIGASFVFRGIALLVWGTNPYALRPFTGHGALEAFGAVIQWQSVWAIILSLASFAALHLFFHRTYIGKAVAACVINPFAARLMGIDIRKMSLGAIAASAGLGALAGIVIAPISGASYDMGMMIGLKAFIAAVVGGLTNAPAAIAGAFLVGLLESFAEGYLSSGYKEAISFGLLLLVLFFMPNGLFAKMTGKRV
>NZ_AP022557.1|WP_081130697.1|2297109_2298483_+|IS1380-family-transposase
MKDFPIRFVLTDEAITPSAGLALVGYLLHRTKLDKRVNALRLPTVRREVHISHSDVIRSMIGLLATGKTDFDHIEAYRQDDIFSASMGIQHVPSSPTLRQRLDQLACLPMTEAIIWEESMRLLVRQHATLSPCWTKGKTTWLPLDVDGSPFDNSDTKKEGVSRTYKGFDGFTPLFAYAGKEGYIVHAELRPGKQHVQDNMPSFLTTAIRRARPLTSSRLLVRMDAGNDAEANVHVCLKEDVDFVIKRNLRRESKALWFQIASQKGRRIDDGQTEGVQTYELCLPQKVAIDGNTYTYVQVTQVTERTMERNGQLMLVPNYEVESYWVRLEGYEHVRMSDVLALYHDHATCEQFHSELKSDLDLERLPSGKMKTNAIVLVMGAFVYNLLRLIGQDLLSDPRHPLHHKVKRRRIKTIIQTVITMAGLLVRRSRQIWMKLTRRSGYSEPLLNVYQKWREAR
>NZ_AP022557.1|WP_033020429.1|2295906_2296677_-|ABC-transporter-ATP-binding-protein
MSAMLLEVEQLSKSFGGIQAVQNVSFYVKKEDIVAVIGPNGAGKTTLFNMISGIVPPTSGFVRFQGAIVSGKQPHELAMLGMTRTFQNLQLFADMTVLENVMVGFHSRLKSGIVSAGFRLPRTVKEEKQAQEQAFFCLEQVGLAHLAWERAGTLPYGMQRLVEIARAAVSRPSLILLDEPMAGLNPQESKQLVDVLLMMREQGFSFLFVEHDMETVMAIADRIVVLDYGKKIAEGAPEEIARHPDVIKAYLGEEAV
>NZ_AP022557.1|WP_033020426.1|2295181_2295907_-|ABC-transporter-ATP-binding-protein
MLTLRNVHVHHGHLHVLKGIDLHVGQGEIVAIVGANGAGKSTLLGTMAGVYAPTEGEILFEQKPLPYGKAEKIVDQGICLVPERRQIFDSLSVRDNLLLGAYRRHRRDGQEVKRDYERVLELFPKLQTMLDRPGGLLSGGEQQMLAIARGLMARPKLLLLDEPSLGLAPLVVKEVMGMLTQLCDQFQTSMILVEQNVRAALQIADEAYVLERGQIVMHGKAAELLADERVAEAYLGAAGRR
>NZ_AP022557.1|WP_033844772.1|2294517_2294985_-|flavin-reductase-family-protein
MDDRMFRRAMGKFATGVTVVTTEFQGEVKGMTANAFMSVSLDPKLVVVSIGHKARMHDIVKQTGKFAVNILRRDQEELSRLFAGQLKEERPVSFEWVNGHPLLAEALANILCNVHSAHVAGDHTLYFGEVTDIIMKDEPGDPLLFFEGQYRSIGQ
>NZ_AP022557.1|WP_033843116.1|2293748_2294312_+|FAD-dependent-oxidoreductase
MYDIAIIGAGPAGASAAIFAAKAGKKTVLFDNDKGMTKRAWVENHYGVPEISGPDLVETGKRQAAKFGAELVETQVTNVQKTDSGFRLETDSGSYEAKHVIFATGVATDLAEKIGLRTKPGTEPRIKTVIDVDANGKTNIDGIWAAGTVAGVSVHTIITAGDGAKVAINVISELNGERYVDHDVLKP
>NZ_AP022557.1|WP_033020442.1|2305172_2305952_-|fumarylacetoacetate-hydrolase-family-protein
MNVRLRLAGRRHLFEAKADWRSGTMTLEGRTAPIDEWEWEAPDVGALYGVALNDRWEWEGMAEAMTAPPYEQPPKGPVLYMKPANTINAHRRPVVLPPGVQRLRAAPAIGLVIGRTAARVRREQALDFVFGYTIINDLSIPHEQRYRPAIKEQARDGFTPVGPWIVPKEETVPLSSLMARVYVNGQLVQCADLRRFRHPPEQWLAEVTEFMTLYPGDVLFFSWPADAPLVAAGDVVRIEMDGIGVLENRIIAEEGGGGA
>NZ_AP022557.1|WP_033020443.1|2306049_2306967_-|2,4-dihydroxyhept-2-ene-1,7-dioic-acid-aldolase
MAYREVKERLRGSIAPVVTPFDEEGNVDLAALTALIDWHIESGTHGISVTGTSGEPSSLTLEERKQVMEAAKKAVAGRVPFVPGTGSTNHAETIELTRFAQEIGADAAMVIVPYYNRPSQQALYKHFQAVAEAVDIPIIVYNIPGRTAVNLEVQTLARLAEDCPNIIGVKESNKDFEHVNRVLWHCGRDFLLFSGIELLCYPMLAIGGAGSISATANVVPQKVAELHDAWFAGDVKRAQDLHFELMELNDVLFIETNPGPVKAALGMMGKITPKLRLPLDLPSEENERKIRRTLVKYGLLAETPQ
>NZ_AP022557.1|WP_033020445.1|2307117_2308101_-|3,4-dihydroxyphenylacetate-2,3-dioxygenase
MAFSIIRCARAVLHVTDLAAARDFYERVLGFVVTEADEDHLYLRGLEEYHHHSLLLKKAPRPAVEALSYKVGSEQELEALYEWFAAQTLQPKWLEAGSQRAVGKAFRVQDPSGLPLEFFVHMEKTERLLQRYDLHRGARVQRIDHFNCAVTDVKSAYDFYVRGLGFACSEYTETEDGKLWAAWLHRKQNVHDLALMNGKGPRLHHIGFWLPDPLSLIHACDVLAAAGYAANIERGPGRHGLSNAFFVYLRDPDGHRIELYNGDYLTSDPDFPPIRWDLDDPRRQTFWGHAAPDSWFEEASIVLDVHSGQPVEPNEPMLAKRKPTFLI
>NZ_AP022557.1|WP_131385718.1|2308134_2308422_-|hypothetical-protein
MQNMTDSIRFSIRETLQNQLSFLNENTADSCVTVVCHRPSKVAAARKQAFSGAQARRIWACCEMFEVKGCGQQQGTFCSMFAIRKDGFFLSATQR
>NZ_AP022557.1|WP_033020446.1|2308507_2309986_-|4-hydroxyphenylacetate-3-monooxygenase,-oxygenase-component
MPAKTGKEYMERLKQAKSSVYIHGEKVEDVTVHPAFRNVVRSMAALYDRQYEKPEKMLYRSPTTGQLVGMTFIQPTTIDELIARREATQEWARMSAGMMGRSPDYLNAEVMAMGIANDLFAEDDSIFAENAKNYYEYAREHDISLTHTLIHPQMNRAKALHEQNDADVPLHLVERRKDGIIVSGIRLLATQGGITDEILVFPSTVKKATSGEDPYALAFAIPNNTPGVKFICREAFDYGRSAWDHPLASRFEEGDAIVSFENVFVPWERVFVCGNSSICNRTFRETNAVVHMSHQVVAKNIVKTEFLLGVTLCLIEAIGIGEFQHVKDKGAEIMLVLETMKSHLYRAEHNAKRDRWGTMTPDFAALDAARNWYPRIYPRLAEIIRILGASGLMAIPTEADFQHEEIGDIVRRAMQGATVDGYERVQLFRLAWDLTMSAFGARQTHYEYYFFGDPVRMGMAYFDGYEKEPYKQFVREFLRGAKSVFIPADTKH
>NZ_AP022557.1|WP_033020450.1|2310208_2311132_+|LysR-family-transcriptional-regulator
MIDVKQLKYFVTIAEEGQITKAAQKLHIAQPPLSQQLKQLEEELGVLLFDRKAKKMELTPPGKAFYEKAKQLLRQLDDAVAEVKEIEDGTAGTLSIGCVKSCFSYLAQAIRHFHEQVPNVTFHLREGDTFSICQLLQERHIDIGIVRLPMNAAHYDVIQLASERYVGVLPAQWNNGRAALCMRDFANWPLLLLHRVHGAGQYERVIEECRRHGFEPNVLCECPDATILLSLVAQGLGATIVPQSTVALFRLPGIDVFEITDSSMTAEAAAILDRQRYLPKSARRFLAVLQTIAANGQQEENGPLLRA
>NZ_AP022557.1|WP_033020451.1|2311276_2312176_-|manganese-catalase-family-protein
MVFQRIDRLAIELPKPKYADPNAAAAVQELLGGRFGEMSTLNNYLFQSFNFRQKNKLRPFYELVASITAEEFGHVELVSNAINLCLTGSTHLGDPDTAPMKDAKDKRNTYHFIATAQTAFPGDSMGKAWTGEYVFNSGNLILDLLHNFFLECGARTHKMRVYEMTDHPTAREMIGYLLVRGGVHILAYAKALEVATGVDVTKMLPIPNLDNRVFDEARKYEDQGVHRRLYTFSDRYYREIARIWRGTHPSDGKPLEVVEGAPQGGTIPDLDEVPEEFAPGISAEDFFAIAKRLQRSAGL
>NZ_AP022557.1|WP_033020452.1|2312193_2312421_-|YuzF-family-protein
MNQSYASPQLFALIDPYVYHTLQGVRGQEVVVETVRGSIQGIVRDVKPDHLVIAAHQAVYYVRLAQVVSVRLGHN
>NZ_AP022557.1|WP_033020454.1|2313028_2314393_-|PepSY-domain-containing-protein
MEQAAKPVDRQRPMYMAVWRWHFYAGIFFAPFLIILALSGAVYLFKPQIESALYGHLYEVDKIGGKRLPLVELTERVKEQYPHYPIVSVTLEKEAKRTVKIGMMDKGEMVFAFVNPYTGKIQGTLRADENWTEIAKKIHSELLIGGTLANRFVELAACWGFVLLVTGLYLWWPRQSFSVFGTFWPRWRAKKRLAWRDWHAVTGIWMSGGILLLIVTGMPWTGIMGEAINQVATATNTGYPPFAFSFGPKPESKVTKEVAQDVPWATEQLPVPSVHGRNTTSLSLDDVYAIAEEKKVKKPFTISLPQGPKGVFTVATSKTKPWDNATLHIDQYSGRVLSDVRFSDYGALAKAITIGIAFHEGRLFGLANQLINLVFCLGLIFLAVSGWVMWRKRKPKGLGAPARVRDPQTVKTVWGGMIAAAIVMPLFALSLLFIWLFDRLIVPRVPKLREFLAA
>NZ_AP022557.1|WP_033020456.1|2314511_2315687_-|response-regulator-transcription-factor
MSKELNDHLLRLLQEAAGILHRYERELNREWERIGKALGKRNVRVKEVFSALCEFVQARLLPYGGEHPTDEQLERIGAFHPEMIIFSLNVMENTVHQVLKAHALAASALHPAVRYLFFKWNEWLLYEVNEQSFKTSRDFAWKTESLWKDAVILFNEWILRAQTLMESARHICFGFSYFLPFNRCALFQFVNQESTAIGLSGHGVDHEHIQRLRVELDNIPMLKESVGKLKAEVHEFRHFRPIYVPRAAEQFPNVYVESFELASLVIVPVYVPTEGRMIGGVVLDRGPGRFFEVDRRLFPALMKFGQSAGELLLKWIEAPKKEWEGMTESLSPREMEILKLLADGASTAEAADQLYLSEFTVRDYISNALRKLNAKNRTEAVAKALRLGLIG

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Crispr_ID: NZ_AP022557_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_20

2521257-2521360

Orphan

Consensus_repeat	Method
TGCCCTCCACCCGGGGATGAAAATCCCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_20

>merge|NZ_AP022557|20|2521257-2521360|CRISPRCasFinder
TGCCCTCCACCCGGGGATGAAAATCCCGCGTCAGTTCGGCATTTTCACGGAAAAGTTCCATGGGCAGTGTGATCTGCCCTCCACCCGGGGATGAAAATCTCGCG

>NZ_AP022557|20|20|2521257-2521360|CRISPRCasFinder
TGCCCTCCACCCGGGGATGAAAATCCCGCG	TCAGTTCGGCATTTTCACGGAAAAGTTCCATGGGCAGTGTGATC
TGCCCTCCACCCGGGGATGAAAATCTCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033842993.1\|2532709_2534302_-\|O-antigen-ligase-family-protein	unknown	unknown	gnl\|CDD\|225844
NZ_AP022557.1\|WP_033843000.1\|2525839_2526727_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl\|CDD\|130274
NZ_AP022557.1\|WP_015375695.1\|2506741_2507875_+\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NZ_AP022557.1\|WP_033843002.1\|2524251_2525265_-\|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|224013
NZ_AP022557.1\|WP_033842992.1\|2534316_2534802_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_AP022557.1\|WP_033842996.1\|2528955_2529837_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|224131
NZ_AP022557.1\|WP_033843017.1\|2505711_2506506_-\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|225412
NZ_AP022557.1\|WP_033843006.1\|2517705_2518836_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340837
NZ_AP022557.1\|WP_033843011.1\|2512873_2514145_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418708.1\|2531740_2532700_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226453
NZ_AP022557.1\|WP_033843003.1\|2523415_2524255_-\|dTDP-4-dehydrorhamnose-reductase	unknown	unknown	gnl\|CDD\|224016
NZ_AP022557.1\|WP_033020681.1\|2509523_2509832_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225215
NZ_AP022557.1\|WP_051962601.1\|2522469_2523393_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133029
NZ_AP022557.1\|WP_081897158.1\|2518840_2519947_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_AP022557.1\|WP_033842999.1\|2526726_2528100_-\|oligosaccharide-flippase-family-protein	unknown	unknown	gnl\|CDD\|240533
NZ_AP022557.1\|WP_172418832.1\|2516329_2517700_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|133003
NZ_AP022557.1\|WP_033843010.1\|2514789_2516196_-\|undecaprenyl-phosphate-glucose-phosphotransferase	unknown	unknown	gnl\|CDD\|274396
NZ_AP022557.1\|WP_172418431.1\|2504479_2504677_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033843013.1\|2509137_2509524_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|182138
NZ_AP022557.1\|WP_033843001.1\|2525261_2525825_-\|dTDP-4-dehydrorhamnose-3,5-epimerase	unknown	unknown	gnl\|CDD\|380337

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033842993.1\|2532709_2534302_-\|O-antigen-ligase-family-protein	gnl\|CDD\|225844	COG3307, RfaL, Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane].	1.40585e-08
NZ_AP022557.1\|WP_033843000.1\|2525839_2526727_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl\|CDD\|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	0
NZ_AP022557.1\|WP_015375695.1\|2506741_2507875_+\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	1.33314e-25
NZ_AP022557.1\|WP_033843002.1\|2524251_2525265_-\|dTDP-glucose-4,6-dehydratase	gnl\|CDD\|224013	COG1088, RfbB, dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane].	0
NZ_AP022557.1\|WP_033842992.1\|2534316_2534802_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.64726e-07
NZ_AP022557.1\|WP_033842996.1\|2528955_2529837_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	8.96855e-179
NZ_AP022557.1\|WP_033843006.1\|2517705_2518836_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340837	cd03808, GT4_CapM-like, capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.	5.14684e-85
NZ_AP022557.1\|WP_172418708.1\|2531740_2532700_-\|hypothetical-protein	gnl\|CDD\|226453	COG3944, COG3944, Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane].	1.75788e-17
NZ_AP022557.1\|WP_033843003.1\|2523415_2524255_-\|dTDP-4-dehydrorhamnose-reductase	gnl\|CDD\|224016	COG1091, RfbD, dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane].	6.03102e-133
NZ_AP022557.1\|WP_033020681.1\|2509523_2509832_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	gnl\|CDD\|225215	COG2336, MazE, Growth regulator [Signal transduction mechanisms].	2.54738e-22
NZ_AP022557.1\|WP_051962601.1\|2522469_2523393_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	6.91625e-65
NZ_AP022557.1\|WP_081897158.1\|2518840_2519947_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.19876e-24
NZ_AP022557.1\|WP_033842999.1\|2526726_2528100_-\|oligosaccharide-flippase-family-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	3.73654e-14
NZ_AP022557.1\|WP_172418832.1\|2516329_2517700_-\|cupin-domain-containing-protein	gnl\|CDD\|133003	cd02509, GDP-M1P_Guanylyltransferase, GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose. GDP-mannose-1-phosphate guanylyltransferase, also called GDP-mannose pyrophosphorylase (GDP-MP), catalyzes the formation of GDP-Mannose from mannose-1-phosphate and GTP. Mannose is a key monosaccharide for glycosylation of proteins and lipids. GDP-Mannose is the activated donor for mannosylation of various biomolecules. This enzyme is known to be bifunctional, as both mannose-6-phosphate isomerase and mannose-1-phosphate guanylyltransferase. This CD covers the N-terminal GDP-mannose-1-phosphate guanylyltransferase domain, whereas the isomerase function is located at the C-terminal half. GDP-MP is a member of the nucleotidyltransferase family of enzymes.	5.74228e-83
NZ_AP022557.1\|WP_033843010.1\|2514789_2516196_-\|undecaprenyl-phosphate-glucose-phosphotransferase	gnl\|CDD\|274396	TIGR03023, Sugar_transferase., Undecaprenyl-phosphate glucose phosphotransferase. This family of proteins encompasses the E. coli WcaJ protein involved in colanic acid biosynthesis, the Methylobacillus EpsB protein involved in methanolan biosynthesis, as well as the GumD protein involved in the biosynthesis of xanthan. All of these are closely related to the well-characterized WbaP (formerly RfbP) protein, which is the first enzyme in O-antigen biosynthesis in Salmonella typhimurium. The enzyme transfers galactose from UDP-galactose (NOTE: not glucose) to a polyprenyl carrier (utilizing the highly conserved C-terminal sugar transferase domain, pfam02397) a reaction which takes place at the cytoplasmic face of the inner membrane. The N-terminal hydrophobic domain is then believed to facilitate the "flippase" function of transferring the liposaccharide unit from the cytoplasmic face to the periplasmic face of the inner membrane. Most of these genes are found within large operons dedicated to the production of complex exopolysaccharides such as the enterobacterial O-antigen. Colanic acid biosynthesis utilizes a glucose-undecaprenyl carrier, knockout of EpsB abolishes incorporation of UDP-glucose into the lipid phase, and the C-terminal portion of GumD has been shown to be responsible for the glucosyl-1-transferase activity.	0
NZ_AP022557.1\|WP_033843017.1\|2505711_2506506_-\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|225412	COG2856, COG2856, Predicted Zn peptidase [Amino acid transport and metabolism].	1.43213e-06
NZ_AP022557.1\|WP_033843013.1\|2509137_2509524_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|182138	PRK09907, PRK09907, endoribonuclease MazF.	1.35375e-34
NZ_AP022557.1\|WP_033843001.1\|2525261_2525825_-\|dTDP-4-dehydrorhamnose-3,5-epimerase	gnl\|CDD\|380337	cd00438, cupin_RmlC, RmlC carbohydrate epimerase, involved in dTDP-L-rhamnose production. RmlC (deoxythymidine diphosphate (dTDP)-4-keto-6-deoxy-D-hexulose 3, 5-epimerase or dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; also known as RfbC) is a carbohydrate epimerase involved in the production of dTDP-L-rhamnose, a precursor of the bacterial cell wall constituent, L-rhamnose. L-Rhamnose (6-deoxy-l-mannose) plays an important role in the cell-wall structure of many bacterial species. It has been found to contribute to the virulence of several species, including the Gram-negative Salmonella enterica and Vibrio cholerae, where it is present as a part of the O-antigen, and is essential for the growth of Gram-positive bacteria such as Streptococcus pyogenes. RmlC converts dTDP-6-deoxy-D-xylo-4-hexulose to dTDP-6-deoxy-L-xylo-hexulose by catalyzing the epimerization of the 5-methyl and 3-hydroxyl groups of hexulose, the third of four steps in the dTDP-L-rhamnose biosynthetic pathway. RmlC belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.80542e-114

>NZ_AP022557.1|WP_081897158.1|2518840_2519947_-|glycosyltransferase-family-4-protein
MNICLVCINSSRSAIGDSFKSLCNNLSEKENVYVIKSFCYNDSEFNYEKHRILSVNFDKRDKNMFRKIDSLLKIKKFVKQNDIKHLFFYSDNPFNALVKMLNNKIDYSFWWHDPKPHTGVKLINKILSKVNESVLLTGKKLNNIFVASNYLKELAEENHLIDSEKIKVIYLPYMEEITLSVQEEVPYDERYYDFIFFGRIEKYKGLDILEQAFYKLHVDGINYKALIVGPGNLNDCTNGLLMKLNGKVEIINRYVSNNELAKYILNSRVAVFPYRDSTGTQTVQTAIYLGCTVVATNTGSFKEYLSVRDSMLGYVIKPNDSNELYKVLLKCLDDHMTHKNNKSTIDMFFNPKTMACNLYRVIHNKNRG
>NZ_AP022557.1|WP_033843006.1|2517705_2518836_-|glycosyltransferase-family-4-protein
MKRVRLLYICEAMGGGVRRHLLDIIENIDLGLYDIHLIYGRNRADQVFLSSLPNLKQKGIYLYEIKELDREISLKKDTKALIEMIKIINSINPDIVHCHSSKAGALGRAAAYLCGIKNIVYTPHAYMAQSLNLSQKKMKFYVGLEKLFSKITKLTINVSEGERQFALQNGIVTINNSTVIYNGIPRKEKPQKIRGNNRIIIGTVARLSEQKDPITFYNIAKNIICKYESVDFRYVGDGPFYEILKNKIESDNLQRRIQLVGFKNNISDQLQEFDIFITTSLYEGMPYALIEALAEGLPIVGTNVTGNNEIIFDGINGYLFNIKDVNGAVQVLEHLINNPEKIKSLGEQSYKIYIEKFTIEKMIKKLELTYQEFERR
>NZ_AP022557.1|WP_172418832.1|2516329_2517700_-|cupin-domain-containing-protein
MEIILLSGGSGKRLWPLSNDARSKQFLKVLENQNGQLQSMVQRVWRQLGNVGLADSVVIATSKSQVDMIQSQLGQSVPIIIEPMRRDTFPAIALASAYLYSVEGIDLNEVVAVLPVDPYVEDRFFDRVKDLEETVLVSGADLALIGVEPTYPSSKYGYIVPTSQSSDGDYLRVSHFREKPTEDKAAALIKQGALWNCGVFAFKLDYLISLLQEKGFPVQYDELVKQYDRLPKISFDYEVVEKTEHIVVLPYDGYWKDLGTWNTLTEEMATNQIGKGVVADSENTHLINELDLPVTVLGVSNVIVAVSPDGVLVADKAKSPKIKELVNGFDQRPMYEERRWGWYRVLDYTRFEDGREVLTKRIGIAAGKNLSYQMHRYRSEVWTIIRGEGEFALNGEIRSVKPGDVLEIPVGAKHGIKAMTDLELIEVQTGTPLIEEDIIRIYMSWDEVEQFCRYVR
>NZ_AP022557.1|WP_033843010.1|2514789_2516196_-|undecaprenyl-phosphate-glucose-phosphotransferase
MIRGRERFLTKVYVSMDFVIIQLAFILSWVMKFHLFHDGINGHLPLKSYLFWSLIYGAIAIVIGYLIELYGPKRKDKFSNELAKVLQVHTLSMFLLLSVLFTSKIVDISRLFLFLYFIWNVMLISIYRYIVKQSLRQLRKKGYNKQFVLIVGAGSIGRKYFENLQMHPEYGLEVVGFLDDFRTKHEPRFAHYKPIIGKVSDLEHILIHQLIDEVVVALPLQAYPKYREIISVCEKMGVRASIIPDFYDILPASPHFEVFGDLPIINVRDVPLDELRNRLLKRLFDVVFSLLAIILTAPLMIAIAIGIKLTSPGPIIFKQERVGLNRRTFYMYKFRSMKHMPQSVSDTQWTVENDPRRTKFGAFLRKTSLDELPQFFNVLKGDMSVVGPRPERPYFVEKFKEEIPKYMIKHHVRPGITGWAQVCGLRGDTSIQARIEHDIFYIENWSLWLDIKIILRTITNGLVNKNAY
>NZ_AP022557.1|WP_033843011.1|2512873_2514145_+|hypothetical-protein
MDHLNYFFPYERKDAHHEDQLTRAFLVTLKMVPFIQHMFIEMIREKMFDKNVNTVNIVPSLVNTEHRIERIETQVKKISQDSGKLISILISDDEFITDHKVHNSERDAVYDGVIYYKPDFIFIIENKPNKNQVRVEQLNPSLPADTQIVIEETPICLSWRSIIERINRLLEKDLVTGAEAVLLSDFLRFIDKNFEFLNPYTTLSVCKDNEYLLKQRCISIMAELNLGPIDYHKSWKNYILVDYGPVKQIAVAPNIKNDGEWAIELEFYAGDTMNQARTFFNRVDVDELLALEHKGWRLEPNFHFAFQGTNLFYPTTRAGIRDYIEFWKARKIKQLNKSNMDEYQSFIDELIRQNMMTPDDKHKLADLFDKTERQTLNVCPGLYFGYQWPKTEAIKLDSAGQLTDAIKEKIQEAARTWENSPTC
>NZ_AP022557.1|WP_033020681.1|2509523_2509832_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein
MNSKEHLESKINQSKGGDYMSTVVAQKWGNSLGIRIPKDVADKIGIKQGSEIELNVIGNEGIITLKPKRTRKKYTLEELISQITPENRHEEIDFGIEGRELI
>NZ_AP022557.1|WP_033843013.1|2509137_2509524_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MPADVPERGDFVVLNFNPQAGHEQAGRRNAIVLSPKEFNQATGFIAVCPITNQKKGYPFEVDLPKEGISPDGDGYPITGVVLTDQIKSLDWKARNLKILKKYNPEDAQIEEIDKIIDECLAKIETYLT
>NZ_AP022557.1|WP_015375695.1|2506741_2507875_+|IS4-family-transposase
MNKHTTLPNLMQKLVSDEEIQLIAEAVGYRDSSRTFTLRELIHFFLLAAMHQWKSFRHGADVGPLYGLPRFHYSTVSKKAKEVPYDIMKRLLALIISKCNRQTRRSLRFPKPLRVVDSTTVTVGKNRLPWAPYHGERAGVKLHVAYSPESSLPADVVETIGLRHDGPVGEQLTNAQQVLVEDRAYFKIERLDRFVEQHQLFVIRMKDNIELHQKKSLKRLSSTSSSVQADFTCQLGTKQCRSTKRHRVVIFRDANGRDIRVVTNLFHASAETIADMYQQRWTVEVFFRWVKQYLNVPTLFGTTENAVYNQLFAAFIAYVLLRWLYDQTKKQTNVSLSFISFVRRFFSGQLPLDWKSGMAAALFEYAQIYGRRMYNFG
>NZ_AP022557.1|WP_033843017.1|2505711_2506506_-|ImmA/IrrE-family-metallo-endopeptidase
MIAKDNLEMILEQNKTHLPKMKKAMDRIYSLGDPLAHVKPLDFIKTYLYEHANVLQFPIQHADYGGLVYYYNGDYYVHINTAQPRIYENFMWAHEFYHFFFDKEKIKNPDQNFIMIDHIYDEKERLPNLFASEFLINDFVLERSFRFLETTHMKQSLPEKIMRLISIFQIPYKALVVKLAQNELITMNEAKDALDYDYRNRIPHDIDKSLFEPSYTINISGFDESYEKAKRLMYEEDLQSIKKSYDRLYEQVLASVHDQRGTKG
>NZ_AP022557.1|WP_172418431.1|2504479_2504677_-|hypothetical-protein
MVFVADVLIGQLIALSNQLRAVTNEIRALEKKVGANNADIQKVKEKVKALNDQVQANKKALLNWL
>NZ_AP022557.1|WP_051962601.1|2522469_2523393_-|glycosyltransferase-family-2-protein
MKQVTDKDVAIIILNWNAYNDTFECLKSLEHLTYPHFHVFLVDNASQDGSFDKLQQDYKDGKFHIPITFIQTGANLGFAGGNNVAIKQAYHQGYQYFWLLNNDTVVDPNALTPLVETLENDKQVGIVGSKIYYYGTNKIWFAGGKVNTWTGKTKHIGIKEEDVGQYDQLREVDYITGCSLGFRREILETVGYMCEDYFLYYEETDWNVRAKLYGWKIKYVPRSLVHHKVSASSGGEKNLSPIVAFYDIRNGYWFVKRTQENKLRIFTAFCYAYYKALKKVLKVFIMNQNRKRRRLVCIYQAVMSIWV
>NZ_AP022557.1|WP_033843003.1|2523415_2524255_-|dTDP-4-dehydrorhamnose-reductase
MKVIVTGAKGQLGMDVVHLLEHKGYKVYGYGREELDITNFDQVKQVISEVKPDVVIHAAAYTKVDLAESERDQAFLVNAYGTRNVAVASETVGAKLVYISTDYVFDGTAKKPYNEFAPTSPLNVYGKSKLAGEQFVRDLHSKFFIVRTSWVYGKHGNNFVRTMLKLAQERDELMVVHDQVGCPTYTVDLAQCIFDLIQTEKYGIYHVSNSGHCSWYEFAKAIFEEAGIEMKVNPCTTQDFQRPAPRPMYSVFEHMALRLNGFHRMRNWREALKEFIHTN
>NZ_AP022557.1|WP_033843002.1|2524251_2525265_-|dTDP-glucose-4,6-dehydratase
MNLLVTGGAGFIGSNFVRYILEKYPTYKVVNYDLLTYAGNLENLKDVEHHPNYLFVKGDINNRELVDYLVKTHEIDVIVNFAAESHVDRSITDPDSFVRTNVLGTQALLDVAKANNIKKYVQISTDEVYGTLGETGYFTEETPLAPNSPYSASKAGGDLLVRAYHETYGLNVNITRCSNNYGPYHFPEKLIPLMITNALEGKDLPIYGDGQNVRDWLHVKDHCAAIDLVIHKGRPGEVYNIGGHNERTNNEIVHLIVEKLGVSKDLIKYVADRPGHDRRYAIDPTKIMTELGWKPKYTFEKGIVETIQWYIDNQEWWKNIKYGEYMKYYQKQYGDKL
>NZ_AP022557.1|WP_033843001.1|2525261_2525825_-|dTDP-4-dehydrorhamnose-3,5-epimerase
MKVTETLLPGVLLIEPSVFGDHRGFFMESYNKQLFAEYGVDFDFIQDNHSLSQQAGTIRGLHYQLNPKAQTKLVRVTRGAIYDVVVDIRKGSPTFGKWQGFILSAENKRQLLVPKGFAHGFCTLVENTEVQYKVDEYYSPEHDRGILWNDPTLGIDWPTSNPVLSDKDTKHPLLSNAEINFEWERPS
>NZ_AP022557.1|WP_033843000.1|2525839_2526727_-|glucose-1-phosphate-thymidylyltransferase-RfbA
MKGIILAGGSGTRLYPLTKAVSKQLLPVYDKPMIYYPLSVLMLAGIRDILIISTPSDTPRFAELLGDGSQLGISLSYAVQPSPDGLAQAFIIGEEFIGDDNVALILGDNLFYGHGLTKLLQKAVERKTGATIFGYYVNDPERFGVVEFDENGKVISIEEKPKHPKSNYAVTGLYFYDHRVVEIAKSIKPSARGELEITDVNKAYLELGELHVEILGRGFSWLDSGTHESLLEASQFIETIEKRQSLKVACLEEIAYLKGYIDREQLLKLAEPLKKNQYGQYLIDIANQKKRPIYL
>NZ_AP022557.1|WP_033842999.1|2526726_2528100_-|oligosaccharide-flippase-family-protein
MMVSSIVTIISGIFLSLVVPKYLGVVEFGYFKLFGFYLGLVGLAHLGFADGILVRYGHYDYESLPKARFRTFFLFLFLTQVVVTGIIIGLLAFFVTNIDKEVIYIMVAINIIFVNIATFFSFISQITKRFRVFAANTILQHLLNMVIIFILIMLGVESYFYYILAQSIVNLLILIRYIIQFRDIVIGKRERLSIVKNEIAHNYRIGFFLLIGNFMGIIILGIDRIFIDHFLSVEEFSYYSFAVSLLGLVFTIINSISSYLYPYIARDRDQLNAQKYKLFSSICVLITSYSLCTFFVIKFIILNYLEDYTDSIIIAAVLYPTVILRSIINIVGVNFYKGLQLIKDYNKNNIVAFVITLLVNVIVVFSTPSLLNFSIGTLLSFYVWWIYTDFYFYKKLNTNTLKDHIFVVLVAALFFLCTKLTVTLGMFSYLLAVTLFTLLFYKDVLVIIKTVRTGVRT
>NZ_AP022557.1|WP_033842996.1|2528955_2529837_-|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIVEEAIASGIEDIIIVTGKGKRAIEDHFDIAFELEQNLMEKGKYDLLEKVKEPSKVDIHYIRQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQADPPCLKQLIDQYEQTLSSVIGVKQVPDHETHRYGIIDPIEQHGRRYQVRQFVEKPAPGTAPSNLAIMGRYILTPEIFLFLDKQETGAGGEIQLTDAIQKLNEIQRVFAYEFEGKRYDVGEKLGFIKTTIEFAVQNEELRKDLIPFMEQMLESVKEKA
>NZ_AP022557.1|WP_172418708.1|2531740_2532700_-|hypothetical-protein
MDETISLRELIETIWKGKWIIAATTIVALLFSMLASFVWIKPTYSANATISVNNGIVPGKQLDETDSYFNEIITPSAYMERVQSIAVIEEGIKKAHLQGKYSPEQVKGNLNIENVPNTNLIRITLKAANPSDTKKLLDGILSAVKQSIWQDIQTGVEKDLHHFTKLKEKERVQLQQTIKLYRQQAVALKLPPSLLLDAVVSYNNQYIITLDSDRLRDISALSEKEVIALNELSNQIKSLADRYRQYVNKEQQLRDFLQSFSIENKILVISAPVVPQAPDSPKPLLNMGIAFVVAIMVGTGLVFFWRYWKETGQERKLES
>NZ_AP022557.1|WP_033842993.1|2532709_2534302_-|O-antigen-ligase-family-protein
MSDWYKYLTIERDEHEDQMDMERVDAILFWGLALIVLVIPLIVRVHIGDFISPSITQTDVLDTGKKADVFTYYKFVALLVSTAFLGLVFLYKVLVLNYQIPKTKINIALAVLGICVTLSAVLAPYKTLALYGLHNRHEGTLTYLCYLMLFFIASNIRYTVRRFQQFIYFLTPFIIINTILGTLNFFGYDVLQLHWVRTLLYSSLPEGAKIAQGSYFLATINHGNYVSGVSAFFVALFFCLAVLEEKRSKKILNGLIASAAFALLLSSLSSNGFVTLVLMSPLFVYMIVKAEKRKVAALSSLVLMVVFVAVYVPFVKQNHRVWDETIGFFIPYNPFQQDHQQAGLNTAFKDIEQVVGHITEKVVSGSTAYADAEEYRLPKLPGPGVAPGSGRAFIWEKALELISDKPFLGYGLDTFPYFFNQDDPEKNSNLGEGYSVIVDKPHNMYIGMAFGAGIVALSALVMVMVGGLIQLLRSIHECFNVHIAALCAGLMAYVIQGMFNDSIIGTAVFFWVGLGVSIGFLHTTNKSIKR
>NZ_AP022557.1|WP_033842992.1|2534316_2534802_-|tetratricopeptide-repeat-protein
MYGKWGRYVFLGLLVFVLAGISYAHWKGQQQDEQFRKDYTEYQQAIQLMQQRQVEQALPILQSLSSKYPDRYNIMRTLGLAYAMKNDFHKAALYYEKAIRKRPFLQQDPIFTLQFGEILYYKGEYAKAKAYLEQSKKLPGSEMYHATIDQLLVQIQHQKSS

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Crispr_ID: NZ_AP022557_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_21

2551013-2551113

Orphan

Consensus_repeat	Method
GGCAGATCACACTGCCCATGGATCTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_21

>merge|NZ_AP022557|21|2551013-2551113|CRISPRCasFinder
GGCAGATCACACTGCCCATGGATCTTTTCCTTGAAAATGCCGGCCTAGCGCGGGATTTTCATGCCTAGGCGAACGGCAGATCACGCTGCCCATGGATCTTT

>NZ_AP022557|21|21|2551013-2551113|CRISPRCasFinder
GGCAGATCACACTGCCCATGGATCTTT	TCCTTGAAAATGCCGGCCTAGCGCGGGATTTTCATGCCTAGGCGAAC
GGCAGATCACGCTGCCCATGGATCTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033018377.1\|2561459_2561600_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912231.1\|2546293_2546779_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912229.1\|2543956_2544736_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033842985.1\|2551326_2552703_-\|aspartate-kinase	unknown	unknown	gnl\|CDD\|236364
NZ_AP022557.1\|WP_033842531.1\|2538692_2539829_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_153017119.1\|2549814_2550729_-\|processed-acidic-surface-protein	unknown	unknown	gnl\|CDD\|275176
NZ_AP022557.1\|WP_033842974.1\|2560543_2561467_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP022557.1\|WP_033842984.1\|2553303_2553738_-\|DUF1284-domain-containing-protein	unknown	unknown	gnl\|CDD\|377735
NZ_AP022557.1\|WP_051962599.1\|2549148_2549808_-\|class-D-sortase	unknown	unknown	gnl\|CDD\|320677
NZ_AP022557.1\|WP_172418709.1\|2540868_2543580_-\|S-layer-protein	unknown	unknown	gnl\|CDD\|375524
NZ_AP022557.1\|WP_033842982.1\|2555364_2556885_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143434
NZ_AP022557.1\|WP_156102687.1\|2557511_2558189_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418711.1\|2546987_2547395_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_AP022557.1\|WP_033842975.1\|2558951_2560559_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_AP022557.1\|WP_172418713.1\|2548392_2548845_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379494
NZ_AP022557.1\|WP_172418712.1\|2547781_2548141_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|180915
NZ_AP022557.1\|WP_033842977.1\|2558398_2558758_+\|DUF779-domain-containing-protein	unknown	unknown	gnl\|CDD\|377532
NZ_AP022557.1\|WP_033842980.1\|2557133_2557508_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418710.1\|2544770_2546114_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366353
NZ_AP022557.1\|WP_033842983.1\|2554047_2554608_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_051962599.1\|2549148_2549808_-\|class-D-sortase	gnl\|CDD\|320677	cd05828, Sortase_D_1, Sortase domain found in subfamily 1 of the class D family of sortases. Class D sortases are cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). The prototypical subfamily 1 of class D sortase from Bacillus anthracis (named Ba-SrtC) covalently attaches proteins bearing a noncanonical LPNTA sorting signal, such as the BasH and BasI proteins, to the peptidoglycan of the cell wall that facilitate sporulation. BasH is exclusively anchored to the forespore cell wall envelope, while BasI is attached to the diaminopimelic acid moiety of the peptidoglycan of predivisional cells. Ba-SrtC lacks the N-terminal signal peptide and membrane anchor. The family also includes many class D sortase homologs from Gram-negative bacteria, but the functions of these enzymes are unknown.	2.93621e-58
NZ_AP022557.1\|WP_033842974.1\|2560543_2561467_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	7.09775e-15
NZ_AP022557.1\|WP_033842985.1\|2551326_2552703_-\|aspartate-kinase	gnl\|CDD\|236364	PRK09034, PRK09034, aspartate kinase; Reviewed.	0
NZ_AP022557.1\|WP_033842984.1\|2553303_2553738_-\|DUF1284-domain-containing-protein	gnl\|CDD\|377735	pfam06935, DUF1284, Protein of unknown function (DUF1284). This family consists of several hypothetical bacterial and archaeal proteins of around 130 residues in length. The function of this family is unknown, although it is thought that they may be iron-sulphur binding proteins.	1.88736e-31
NZ_AP022557.1\|WP_153017119.1\|2549814_2550729_-\|processed-acidic-surface-protein	gnl\|CDD\|275176	TIGR04383, hypothetical_protein_HMPREF1015_01194, processed acidic surface protein. Members of this family are acidic surface proteins with an N-terminal signal peptide and a variant C-terminal sortase recognition sequence, LPXTA rather than LPXTG. The N-terminal region past the signal peptide is repeated a second or third time in many members of this family. Members occur in Firmicutes, encoded next to a dedicated sortase related to SrtC that assembles pilins, suggesting that this protein serves a structural rather than enzymatic role. Processing by the neighboring sortase may result in polymerization as well as surface attachment. [Cell envelope, Surface structures].	1.14259e-112
NZ_AP022557.1\|WP_033842531.1\|2538692_2539829_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_172418709.1\|2540868_2543580_-\|S-layer-protein	gnl\|CDD\|375524	pfam18058, SbsC_C, SbsC C-terminal domain. This is the C-terminal domain found in Bacterial Cell Surface Layer Protein SbsC which can be found in species such as Geobacillus stearothermophilus. The C-terminal domain is the third and last triple-helical bundle and adopts a canonical coiled-coil structure. A similar overall arrangement of antiparallel triple-helical bundles has been found in the cytoskeletal protein spectrin (2SPC).	1.18601e-24
NZ_AP022557.1\|WP_033842982.1\|2555364_2556885_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143434	cd07116, ALDH_ACDHII-AcoD, Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like. Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane. These proteins apparently require RpoN factors for expression.	0
NZ_AP022557.1\|WP_172418711.1\|2546987_2547395_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.21453e-16
NZ_AP022557.1\|WP_033842975.1\|2558951_2560559_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.35795e-73
NZ_AP022557.1\|WP_172418713.1\|2548392_2548845_+\|hypothetical-protein	gnl\|CDD\|379494	pfam14183, YwpF, YwpF-like protein. The YwpF-like protein family includes the B. subtilis YwpF protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 146 and 167 amino acids in length. There is a conserved IIN sequence motif.	3.90473e-62
NZ_AP022557.1\|WP_172418712.1\|2547781_2548141_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|180915	PRK07275, PRK07275, single-stranded DNA-binding protein; Provisional.	1.32783e-50
NZ_AP022557.1\|WP_172418710.1\|2544770_2546114_-\|peptidoglycan-binding-protein	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	2.60951e-36
NZ_AP022557.1\|WP_033842977.1\|2558398_2558758_+\|DUF779-domain-containing-protein	gnl\|CDD\|377532	pfam05610, DUF779, Protein of unknown function (DUF779). This family consists of several bacterial proteins of unknown function.	1.31066e-71

>NZ_AP022557.1|WP_153017119.1|2549814_2550729_-|processed-acidic-surface-protein
MVSKRLIIIALVVTLSAFPLKADAISRSELEQYAASVGWTVSDLLAYLDRYGLTAADFRTIDELKQWVGTPLTEPLFHDVLRRHRLTVEELEALLGQFGETVQDYLFVEDLDRAIRFYSQHNAAMQQINDLLGALGMNEQEVRKFSRHVASLSDPQLSGKLRALRARLRPFEETEGPWTSEQRRELKAIWQEALALLELNAHCSADWSGIKAAGAEPLHVRLYNRQGEQVADVALTREMLSSGYIVRAGEKGIEAGLLALEMKGAMYGEKLPETASPYLARTLAGALLACAGLYLYRRTARWRG
>NZ_AP022557.1|WP_051962599.1|2549148_2549808_-|class-D-sortase
MKRKLATAFLSSLCPIFRCTALVLLVIGIWLVGWNGYWYMVGWKAAKPDRVLSSLKQESGSNANTSVSADWAGKRAKSSPSSALGAYLGEMTIPKLGVAIPVYEGVREQELRRGVGHYPNSAWPGGEGHVVLSGHRDTVLRRLGELGIGDAIILRTEGAAVHYRVVNVRIVDDEDRTVLVDKARPTLTVTTCYPFHFIGRAPKRYVVIARPVRVDRLKL
>NZ_AP022557.1|WP_172418713.1|2548392_2548845_+|hypothetical-protein
MKTFKLVGLSVIDDERQRQDIPFIDGLIINKEDGQNRWLVEAYLDDEYEPVFASLQQQPEFQLQVTITNPGNDPANMLVAVRSITKMNGHISVLMEGLMIPRRTRLAEIVLEGLVEKGLQGEALLQAFRQQFRQQMEKQQNAKAPREAKR
>NZ_AP022557.1|WP_172418712.1|2547781_2548141_-|single-stranded-DNA-binding-protein
MCRGMINQVVLVGRLTKDPELRYTADGAAVATVTLAVARNFRNAEGGIDADFVPCVLWRKTAEHTANFCRKGSMVAVTGRIQTRRYDNKDGQRVYVTEVVAQSVQFLHSGKQPEWPEHV
>NZ_AP022557.1|WP_172418711.1|2546987_2547395_+|helix-turn-helix-domain-containing-protein
MTTLGETLKQLRKQRRWTQERLAEQLNVSRSQISKWENGSLLPDVQSLEKLCRLFGVSADFLLGGEARRRELLREVADQYGAVGVSDTALTAFSYLLQNEEMSAAIYTLAKLPDKKRKHIETMIATIIKECSELL
>NZ_AP022557.1|WP_061912231.1|2546293_2546779_-|hypothetical-protein
MHIYLADIVVCERNNQKRAKPVYRIYIKEMKNPFSVQLKTIAPSSFTDSLRSLKSANSRECAPFEEEATFRTITCSPDAQLYFVLKCISQLYMFIVKLDLRQKKFTVALYEWNSLQQKYIPLRVDEWLAMEKQLIYEILQSIHLVEDRRVSYWLTCPSRSK
>NZ_AP022557.1|WP_172418710.1|2544770_2546114_-|peptidoglycan-binding-protein
MKPSHVVFTAAMASAFFLAPDDSQAAEWKKGMSSPEIKQLQLRLKAQGFFTYPQATGYFGAVTEEAVKAFQRAMNLPVTGSVDPATYAKLTVSASSRTLAIGSRGDEVRELQQRLKRLGYFRYPQITGYYGAVTAEAVKQFQRDNRLAVTGRADQATLERLKQTEGSVSSSVGLSVGSRGSQVRELQRHLKQLGYFTYPNITGYYGEITAEAVRRFQRANGLPATGVVDSRTAARLGNAVKAKISPPPTSKRPSLLLSIGSRGEEVKRVQQKLRELGYFINSDITGYYGAVTADAVRRFQQAAKLPVTGVVDSQTYERLLGQAPAVKLDVIELVADAAELLGAPYVWGGDAPEEGFDCSGFIFYLFQQQGVTLPRTVALMWKAGAPVSAPEVGDIVFFATTTSGPSHAGIYIGNGQFIHSGASTGVTISRLDQSYWKQRYLGAKRLF
>NZ_AP022557.1|WP_061912229.1|2543956_2544736_-|hypothetical-protein
MKHASKTAAAICLAAAVALGGNGQAVDAAVQWGHVQWKQGMIGKVVILRDTSLYRLNGMAWQSAMTAKQGREYRVYSQKRAGGAVYYSLGGGLYAKQGDAIQYVPFTKDELLSLVARSLKGQYILQAGNESAPFVIERKKGSRLFGWYLYGQRMSLPIEGRIDGATVTLSIFFNDNVKAIADSISYLKAYNVPKEEIEKIAEQLANSGDYAMQLQFSITNSPEQFSGQFRFLDLYLNDRYDVVKMTLGQPMDVTVKKND
>NZ_AP022557.1|WP_172418709.1|2540868_2543580_-|S-layer-protein
MDKKKAVKLATASAVAASAFVAANPHASQAATDVATVVSQAKAQMKQAYYTYSHTVTETGKLPNISDVVSAYNKAKQAYKNAVAVVNKAGGAKKDAYLADLQATYETYVFKANPKSGEARAATYIDAYNYAVKLDKMRRDLDGAIKAKDLKKAGDLYHKISYELKTRTVILDRVYGQSTRELLRSQFKAEAQKLRDSLVYDITVSMKAREAQDAVKAGNLDKAKAALDQVNQYVSKVTDAFKAELQKAAQEANAAYEAALPPKVESVTAVNAKTLEIKFNKAVDAATVIDNKGTSDTSDDVVKTTAITLTAIDGQGTVSTVKASLSDDKKTLKLVADGAQFFTKRYVVDIKSVKTLDGKDVPAYTTTIDTTDSVRPSVLSFSYADNGLTLKVKFSEPLASVGTVKLYDGTTEISVSPKFTAGDDEMTINLASSSVPVNKDLTLKIFGAVDYNGNVINPNPAELTVKKTTVDTTKPVVQSIEAVNTKTVKVTFSEKLLSAPTIKIGGQTASVSVDSTGLVYTATLASALSEGVYAVEVSDYKDLAGNAGDAYTKVVQLKADNTAPKFVSSQVVKIDGVEHLVLTFDEEVTTGSNITVVQANDKYIDENNVLKSVNTTLTTTSDNFKLYLPTDGKSKSVALNISSLPKGTYTVTLPNGLVSDLAGNPYAERKQITFVRGSDSLTTKPALDTAYDDNGVKADNNNELVFAFTQNLDASALNLSNFNINSLTVTKAVFDGDTKYIRVTLAPGANTWTGTHVITISNIKNTSGLVMDTVTVNEYMKENVAPTFTATLTSADVIRVDFSEPVANKTINSQLSSSNFTVKVDGNVVNVAGVYEESTANHTVANSKGYKTVYLKLNNPVTDLSKPITLSATGIVDVDKVGSITDANKVGNEVSDAVVNVAK
>NZ_AP022557.1|WP_033842531.1|2538692_2539829_-|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_033842985.1|2551326_2552703_-|aspartate-kinase
MKVAKFGGSSVASAAQFRKVADIVSSDIERRIVVVSAPGKRYKDDVKVTDLLIRLAEQVMAGEPYGQTVEAIVKRYADIVNELGLEAGHFLGELNDDLQSKISAYRHEPPRLLDAMKASGEDHNARLMALYLQDRGLAASYVSPLEAGIIVTDEPGNAQVLPESYDKLNQLRDRRGVLVIPGFFGYSPSGHIVTFPRGGSDITGSIVAAGVQADVYENFTDVDSIYCVNPSIVVDARKLKEITYREMRELSYSGFSVFHDEALEPVYRAGIPVCVKNTNNPAAPGTWIVAKRNHIDEPVAGIASDTGFCSINISKYLMNREIGFGRRVLQILEDEGISYEHTPSGIDNMSIILRADQLAEGKEARILARIREELAVDEVTVEHGLALIMVVGEGMEKTIGMAAKATMALAKANINLEMINQGSSEVSMMFGVKEEVVNEAVRALYHAYFRELTVTRPS
>NZ_AP022557.1|WP_033842984.1|2553303_2553738_-|DUF1284-domain-containing-protein
MKPLRLRGHHLLCVHGFRGMGYSPSFVEKMSEIVARIRDETDDFPIEVVAALDEACLVCPHHGETTCEAGPDSDAHVRSLDGNVIRHLGLQPGSVYWKSELIERTAERVKPDDLDELCRGCSWLPYGVCKEGIANVRRGNVAQT
>NZ_AP022557.1|WP_033842983.1|2554047_2554608_+|hypothetical-protein
MTKEEAARLLSILLHDLTKEWRKEKIHSDVLEVIMQLRIQAADNERYSANLLDQIAFAGESAHALKQIWGYMLRERTFLSPTTMEAMLTDAQRVIHRRLPELVPRYGRAFAEIADETERKRQLERSYSALLLFNRIATDFLFQFVRKENEREASAFFAADPNELLEVFHHLCSVYASRLLEGLEVD
>NZ_AP022557.1|WP_033842982.1|2555364_2556885_+|aldehyde-dehydrogenase-family-protein
MIYAQPGQPGALVTFKKRYENFIGGKWVPPVDGEYFENITPITGQPYCEVPRSKAADIELALDAAHAAKEAWGRTSPAERARLLNKIADRMEENLEMLAVAETWENGKPIRETLAADIPLAIDHFRYFASCIRTQEGTISEIDHDTVAYHFKEPLGVVGQIIPWNFPILMAAWKLAPALAAGNCVVLKPAEQTPTSILVLIELIEDLLPPGVVNVVNGFGLEAGKPLASNPRVAKVAFTGETTTGRLIMQYASQNIVPVTLELGGKSPNIFFPDVMDKDDEFLDKALEGLTMFALNQGEVCTCPSRALIHESIYDAFMERALERVKQIKQGNPLDTETMIGAQASSEQLEKILSYIDIGKQEGAELLIGGERNMLEGELAGGYYVKPTIFKGHNKMRIFQEEIFGPVLAVTTFKDNDEALAIANETLYGLGAGVWTRDINTAYRFGRGIQAGRVWTNCYHLYPAHAAFGGYKMSGIGRETHKMMLDHYQQTKNLLVSYSPKKLGLF
>NZ_AP022557.1|WP_033842980.1|2557133_2557508_+|hypothetical-protein
MKKSFVCFLFVIFSFLCNGCELRAYHADENEHHDNNPLTVMKWNVSAPNWTHASLVGNELFIAVNADQTNRASVNELLAVNVKTKKQRMLFQSAHEEAMVQWVQANNRWVVWEDSTSFGAESTI
>NZ_AP022557.1|WP_156102687.1|2557511_2558189_+|hypothetical-protein
MDRKTGSTFLAARSNSSPPTVFNPVLDGDYVAWAEKGSQFGQVKLFHLPTKQGKTIGRLVSQGLYNEFVSLRNGKVIWTDSHDGKGYYYVYDIRTGRSASYESPAPFPAYAEYDNGLIYAIHLEDLEYPDQQTFGYFDLKTKRFSRFPVSHGIIQYFDVSNGKLAFLDDRGAVSVYEQRNGKWKAVKVSLDRYPRLLYFDQQDHLIVDQEDTKQDRRWLNIVKWP
>NZ_AP022557.1|WP_033842977.1|2558398_2558758_+|DUF779-domain-containing-protein
MMEEPKVIATEAALALIDKLKAKYGPLMFHQSGGCCDGSSPMCYPLGELIVGDSDVLLGEIGGCPFYIAKAQYEYWKHTQLIIDVVPGRGGMFSLEGPEGVRFLTRSRVFGQGADAGAP
>NZ_AP022557.1|WP_033842975.1|2558951_2560559_-|MFS-transporter
MEKALTAPVGTIRHRSLLITGLVIAMLFAALDGTIVGTAMPRIVGELHGLGIMTWLTTAYMLTSTTVVPIAGKLADLLGRRLVYVSGLVIFMIGSALCGMANDMTQLILYRGLQGIGGGIMMPMAMVVIGDVFTGKERAKWQGVFGGLYGLASVLGPQVGGFIVDHLSWRWVFYINLPVGIVATVLIAMGLSKHKAEGPVKFDVAGMTTLTVGVVSLLLGLTFGGDRYPWGSWQIISLFALAAAGFVLFALAEKRAAEPIIPLWLFRNRAFTLLNGIGFFMSIGMFGAIMFVPFFMQGIIGVSATQSGTIMTPMMITMIISSVIGGRLVYRIGVKPQLIIGMAVMVAAFGLLGTMGIDTSKWTATLYMMILGLGTGLVMPILTLALQESFSKSELGVVTSSSQFFRSIGGTFGMTVLGAVMNERSSALLDERLMPKLEALPAQAKGLVDRFADMIHSDPQGLYSVLFSPETMAKIPAPLRDMFVPVLKQSLVDSLQAVFWFGLAFIAVGLLLVFGLKRIVLSDRAEAMKQARETE
>NZ_AP022557.1|WP_033842974.1|2560543_2561467_-|TetR/AcrR-family-transcriptional-regulator
MDERRTQFIEMAMKLFAEKGYHATSIQDLVDAWGISKGAFYHHFASKEDLLLAVLRHYSEKMVAELTADDGEGTEKERWIRQLSAHFSHIHEYKDFLRMIMSEQLPKVNPEVERYMFRQHGRLFWWYCTRLEDVYGEAVRPYVYDVAMMINGIVRQYLFYCFFHEEALNADEIARFLARRFDAIVASFAADEPPLLTKESLAPWVELEERERQRQRERLASAFSAARAAARELRSKQAREMLEAIAALEEELLGRDGSPRAYLVEALRLYLRQHAAPPLADALAALNDEIQAYQQSERWERETWRKH
>NZ_AP022557.1|WP_033018377.1|2561459_2561600_-|hypothetical-protein
MTDVRKLVEWLRRRGVRASLVKPRIALRSDRSWLTAGKQGMSRCHG

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Crispr_ID: NZ_AP022557_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_22

2581396-2581490

Orphan

Consensus_repeat	Method
CTTCCAGCCGAACGTGGTCGAACGTCAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_22

>merge|NZ_AP022557|22|2581396-2581490|CRISPRCasFinder
CTTCCAGCCGAACGTGGTCGAACGTCAAGTAAATCACCCAACGTTCTGAGACTGAGACGCTGGAAACTTCCAGCCGAACGTGGTCGAACGTCAAG

>NZ_AP022557|22|22|2581396-2581490|CRISPRCasFinder
CTTCCAGCCGAACGTGGTCGAACGTCAAG	TAAATCACCCAACGTTCTGAGACTGAGACGCTGGAAA
CTTCCAGCCGAACGTGGTCGAACGTCAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033842957.1\|2583834_2585178_-\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|133432
NZ_AP022557.1\|WP_033842956.1\|2585302_2586070_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_AP022557.1\|WP_033842966.1\|2574893_2575715_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_AP022557.1\|WP_033842965.1\|2575714_2576686_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_AP022557.1\|WP_033842968.1\|2569301_2570315_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236863
NZ_AP022557.1\|WP_014196859.1\|2570304_2570961_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NZ_AP022557.1\|WP_033842954.1\|2590825_2592193_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|178402
NZ_AP022557.1\|WP_033842959.1\|2581574_2582588_-\|sugar-binding-protein	unknown	unknown	gnl\|CDD\|380537
NZ_AP022557.1\|WP_033842967.1\|2571969_2573361_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274819
NZ_AP022557.1\|WP_081897157.1\|2573482_2574268_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|378820
NZ_AP022557.1\|WP_033842952.1\|2593249_2594329_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_AP022557.1\|WP_033842963.1\|2578354_2579896_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|381091
NZ_AP022557.1\|WP_033842964.1\|2576747_2578043_-\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NZ_AP022557.1\|WP_033018366.1\|2571077_2571908_+\|methionine-ABC-transporter-ATPase	unknown	unknown	gnl\|CDD\|270317
NZ_AP022557.1\|WP_033842958.1\|2582730_2583621_-\|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl\|CDD\|273806
NZ_AP022557.1\|WP_033842953.1\|2592271_2593249_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_AP022557.1\|WP_081130697.1\|2589251_2590625_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_AP022557.1\|WP_033842950.1\|2596236_2596437_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378933
NZ_AP022557.1\|WP_033842961.1\|2579873_2581343_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NZ_AP022557.1\|WP_033842951.1\|2594404_2595697_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033842957.1\|2583834_2585178_-\|6-phospho-beta-glucosidase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_AP022557.1\|WP_033842956.1\|2585302_2586070_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	7.96731e-61
NZ_AP022557.1\|WP_033842966.1\|2574893_2575715_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.70861e-79
NZ_AP022557.1\|WP_033842965.1\|2575714_2576686_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.65032e-78
NZ_AP022557.1\|WP_033842968.1\|2569301_2570315_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|236863	PRK11153, metN, DL-methionine transporter ATP-binding subunit; Provisional.	0
NZ_AP022557.1\|WP_014196859.1\|2570304_2570961_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	3.73516e-101
NZ_AP022557.1\|WP_033842954.1\|2590825_2592193_-\|FAD-binding-protein	gnl\|CDD\|178402	PLN02805, PLN02805, D-lactate dehydrogenase [cytochrome].	7.33287e-132
NZ_AP022557.1\|WP_033842959.1\|2581574_2582588_-\|sugar-binding-protein	gnl\|CDD\|380537	cd06314, PBP1_tmGBP, periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs. Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs from other bacteria. They are members of the type 1 periplasmic binding protein superfamily which consists of two domains connected by a three-stranded hinge. TmGBP is specific for glucose and its binding pocket is buried at the interface of the two domains. TmGBP also exhibits high thermostability and the highest structural similarity to E. coli glucose binding protein (ecGBP).	4.19167e-108
NZ_AP022557.1\|WP_033842967.1\|2571969_2573361_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	0
NZ_AP022557.1\|WP_081897157.1\|2573482_2574268_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	9.16748e-14
NZ_AP022557.1\|WP_033842952.1\|2593249_2594329_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	0
NZ_AP022557.1\|WP_033842963.1\|2578354_2579896_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.16148e-47
NZ_AP022557.1\|WP_033842964.1\|2576747_2578043_-\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	1.29703e-56
NZ_AP022557.1\|WP_033018366.1\|2571077_2571908_+\|methionine-ABC-transporter-ATPase	gnl\|CDD\|270317	cd13599, PBP2_lipoprotein_Gna1946, The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold. Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.	6.10724e-107
NZ_AP022557.1\|WP_033842958.1\|2582730_2583621_-\|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	8.86758e-11
NZ_AP022557.1\|WP_033842953.1\|2592271_2593249_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	0
NZ_AP022557.1\|WP_081130697.1\|2589251_2590625_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.25216e-16
NZ_AP022557.1\|WP_033842950.1\|2596236_2596437_-\|hypothetical-protein	gnl\|CDD\|378933	pfam12725, DUF3810, Protein of unknown function (DUF3810). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 333 and 377 amino acids in length. There is a conserved HEXXH sequence motif that is characteristic of metallopeptidases. This family may therefore belong to an as yet uncharacterized family of peptidase enzymes.	0.00277235
NZ_AP022557.1\|WP_033842961.1\|2579873_2581343_-\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	2.58738e-60
NZ_AP022557.1\|WP_033842951.1\|2594404_2595697_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	5.05301e-166

>NZ_AP022557.1|WP_033842961.1|2579873_2581343_-|sensor-histidine-kinase
MNIRTKMLLCFTVFLLLLNGAVFLLYETSEEMMSDYDHRMRRLLLLNEVSQRANRMMEQLNAYVSEKEGRYARAYEQEFRWLQQRRRQLGAILPVLSDRLAAENYEHMIESLLEEAALTVYHFQAGNIGLYSSHLHETMNIASFLQEETLNLIDDELTAYQRRYDEVERRNRYFRYMGMGLFVTTLLLGALLAVFFSGHLTKPIILLSRAARSIADGRLDGPDIEPMTNDELRLLTITFNDMRRNLKRLIAEMKQKAELDRLVKELELKSLQSQINPHFLFNTLNTVAKMAYLEDAQQTSRLIEAVAAILRYNLGDLQRTVTLADEVRIAREYFFIQQTRFFDRIKFSLEAEPSCLDQPIPPLTLQPLIENAFIHGIETYEQGAELSVSVFAENGRVVVEVRDNGVGMDEQVKAELDALIRGEEPPARREQGRGHSTGIGLRNVIRRLQLFYGAMDVAKIESAPRKGTTVRLWLPRWQGGMSGESGDRR
>NZ_AP022557.1|WP_033842963.1|2578354_2579896_-|AraC-family-transcriptional-regulator
MKVAIVDDEALERRALCKMINDHLPDVEVVAEGANGREAIDIAKQYCPDVMLIDIKMPGLDGLQAIEAIRQDGLDIEFIIVSAFDLFDYAKQAMRFGVKEYVLKPSRKEEILSALERVSQEIAVKRQHEERNRQLHEQIRRLQTFVENEWLSVLMTEDVPAEEWERWKELLPFSLAVGMFIVLQFPDPAKSDEWKSWASEQLEEQAPARYLIGRMASGRLPVLFFQSPDDAELAWKSAIQTLALDLTRRFSSRYGAALYIGLGSPVSRLDQLRLSYYEALSAARYYAEQQKAQVGFPPAEAMRVGRAAERDQQLFEALRLGDIEQARFVCRTYIDELTSSFPLLSAARKAEETFIWMGRLLAELGIRYGRIVSFASCRSAAQLKRAALDELDRIAADLEVWRQQHAHGKLGKAKEYIDRRYAEPLTLEEVAEQAGMSPYYFSKLFKEQFGITFIDYVTNVRIERAKEALARTDLSLKEICFSIGYNDPNYFSRVFKKQTGLSPSEYRKKVQAR
>NZ_AP022557.1|WP_033842964.1|2576747_2578043_-|carbohydrate-ABC-transporter-substrate-binding-protein
MRKRASAWLALALGVGVALSGCSSNSSSSDDAKQGSQKAGEKLEIFSWWTGAGEEDGLKALIKLFQEKYPDIQVENAAVAGGAGTNAKAVLASRMQGNDPPSTFQVHGGAELNEGWVAAGKMEPLNDLYEKEGWMDKFPKALIDMVSKDGNIYSVPVNIHRGNVLWYNKKIFADNGLQPPKTFDEFFQVADKLKAKGITPLALGDKEPWAATHLFENVLLGTLGTENYKKLWTGELSFNDPQVKQAVETFKKMLGYINEDHSSRNWQDAAQLVAEGKAAMYVMGDWVKSYFVNDLKLKVNQDFGYVPVPNTEGKFMVITDTFGLPKGVKNPDDVKKFLAVLGSVEGQDAFNPLKGSIPARIDADPSKYDEYGKQTMQDFKTAELAPSLAHGSAAPEGFVTKVNQAVNIFVTQKDVKTFIDTLASAAAELKK
>NZ_AP022557.1|WP_033842965.1|2575714_2576686_-|sugar-ABC-transporter-permease
METVNITPAEKTAYVPSVRKKRKWTADHWLAAAFLAPSVVLIFLFVYGFIGWTGYVSLSNWNFLVPDWSFAGLKNYLYLFHDFRFQADLRNTLVFTVLFIAAVIVLGQLLAILLDQKLRGESLFRNIFFFPMALSFVVTGVVWQWLFNPSTGVNLFLKPLGLDGKWYTDTNILFGFHWGKIEFGIPVAIIAVVVAAVWQMTGFAVAMYLAGLRAIPDEVREAARMDGATEFQLYWKIILPLLRPITVSVIIIMAHISLKIFDLIYAMTGPGANFVTDVPGVYMFETTFRGNYYANGAAIAMVMLLSVAIFIVPYLISSRKGGS
>NZ_AP022557.1|WP_033842966.1|2574893_2575715_-|carbohydrate-ABC-transporter-permease
MARSVWARPFLYALAVAMSVFFLMPVYVMVITSLKPLDEVTLADMWKLPSTIDWSSYATAFDKLAPNFWNSLLLVVPATLLSALLGALNGYVLSKWKFKGADTLFTLILFGMFIPYQSILIPLIQFLREIGLYNTIPGLVFVHVVYGIPITTLMFRNFYAAIPDEMIESAKIDGAGFVRIFRYIMLPLSITGFVVVAIWQFTNIWNEFLFAVTITTSDKQPIMVALQNLSGSQIVQWNVQMAGALLAALPTLLVYIFLGKYFVRGLLAGSVKG
>NZ_AP022557.1|WP_081897157.1|2573482_2574268_-|alpha/beta-fold-hydrolase
MIRFQYIESGGERLAVSIHDPAVSVDRDDVPVVVICHGFIGTRIGVDRLFVQAAERFASAGVGVVRFDYAGCGESSGEYGKNRFDDFIRQTRDVIRTVEQFPSFQRRPLVLLGHSLGGAVATVTAALDRRVERLVLWAPVAYPHADIVRIATDGYGRSDGETIEYRGYRLSPSFFTSLVDIDPLQAAKQFPGDVLLVHGIADQEIPVTYADVYGEAFGQRADSRFAKQVIPEADHTFSSVSAREQLLQITTAWLFQRAVVV
>NZ_AP022557.1|WP_033842967.1|2571969_2573361_+|LLM-class-flavin-dependent-oxidoreductase
MDQPLLFNAFEMASAMHNAHGLWKHPDSERHRRYKELHYWIEMAKRLEAGLFDAVFFADVLGVYDTYRQSKDPSIRDGMQFPLNDASLIIPVMASVTTHLSFVLTASTTYEHPFHIARRFSTLDHLTNGRIAWNIVTSYLPNAAKNFGLERMIAHDQRYEVADECLEVTYKLWEGSWEEGAFLEDRETGVLIDPGKIHPINHHGAFFSVEGPHLCEPSPQRTPVLYQAGSSERGRAFAAKHAECVFVGAPSPERLSFYIQDIRQRAERYGRDPQQLKFFTFLTVIVAKTTEQAEAKYEQLRRLWSMDAAKAQFSGASGYDLAEYEAKPADEPFLFRATDHGHYKAASLTKDATKPLTIGEALQKAGTLTRESVIIGNPIQVADAIEERARRSGVDGFNLTHLITPKDLDDFIEYVVPILQRRGLYKTAYTPGTMREKLFGNGPRLAHDHPAAAFRPIGSRTDG
>NZ_AP022557.1|WP_033018366.1|2571077_2571908_+|methionine-ABC-transporter-ATPase
MKRFSFLFALIVLIFGATGCSSSSSSAQEEKKTITIGATAGPYSDQIREAIQPYLEKKGYKVKLIEFNDYVQPNIALDQKEIDANVFQNQMYLENFAKTHQMKLQPLISIPTVPIGLYSKKHTSLDDIRDGTTIALPNEPVNQARALTMLQQLGLLELKKDVEPTKASEKDIAKFHKNIILKPLDPAQLPRALGDVDYALINGNFALSSGLKLTEAVALEKTPDYYLIVVTIRPEDKDKPFVKDLIAAYKSKEFAKLIKEDPKYKGYVWPDWFQKQ
>NZ_AP022557.1|WP_014196859.1|2570304_2570961_+|ABC-transporter-permease
MPLEALAPELLKAFWDTLYMVGISLLAAVIAGLPLGVLLFVTDRGLFWENKPLQTILGFLINIVRSIPFIILLVALLPLTKLLVGTTIGPTAAAVSLSVAATPFFARIVETALREVDKGVIEAATAVGATPWMIIKDVLLSDALPGIIHGLTITAISLIGYSAMAGIVGGGGVGDLAIRFGYYRYDNTVMITTIIILLCLVQVVQFVGDSIARWIDKR
>NZ_AP022557.1|WP_033842968.1|2569301_2570315_+|methionine-ABC-transporter-ATP-binding-protein
MIDIEQLTKMYNVHRKEVVGVDHVSLSIQSGEIFGIIGHSGAGKSTLLRCINLLERPTSGRIIIDDTDITALSGAALREARLKIGMIFQQFCLIRSKTVFENIAFALRAAGKTKTEIETRVHELLEMVGLLDKRDAYPSQLSGGQKQRVGIARALANNPTVLLCDEATSALDPATTSSILQLLKQINRELGITIVVITHEMEVIKEICDRVAVMQNGRIVEIGRVYDLFTQPQQPLTRSFVEHVLRLDVPERLLQARTGTLVRILFQGPAAEQAILSDTLQTFRVRGNILHGKIEYINDTPLGVLLLELSGDEQEVERAIRYMAERTKGVEVIDRAA
>NZ_AP022557.1|WP_033842959.1|2581574_2582588_-|sugar-binding-protein
MRDWWKRLFYGGGIAALLASASFTAYCAWNVYAYPKSEKERVPETTKEAYHFVLVPEELDNDYWRLVEKGAKAAAKELGVDLEYIGPRQANIDEHLRILKKAAAAKVDGIITQGLTEAEFVPVINEITDKNIPVVTIDTDAPMSRRVAYVGTDNYYAGFLAGRALAEDTEGKATVAIITGSLTAAHQQLRVRGFEDAVRQEKGIRIVAIEESHITRVQAAEKAYTILKKHPDVNAFYGTSALDAIGVAKVVEQFHREQKTYIIGFDTLPETIRYLQKGTIAATVVQEPYEMGYKAVQLMAELVAGKDVPAVTNTETKVIRKKDLPLRPARNYEVNTP
>NZ_AP022557.1|WP_033842958.1|2582730_2583621_-|Rpn-family-recombination-promoting-nuclease/putative-transposase
MSETRIDHNRLFKELLSTFFEEFLLLFFPHVYEQVDFRHVTFLSEEVFTDVAVGEKHRVDLLVETKLKGEDGLIIVHIEHQSYTQPAFPERMFLYVSRLFQKYRRRILPIAIFSYDAIRDEPSSFTIQFPFLTVVDFRFLTVELRKLPWREYIRRDNPVAAALLSKMGYNESERVAVKKEFLRMLVRLELDEAKQRLLFGFFETYLRLSEQEELELRNEVNEMETKEAKKVMDLIVSYEQRGMEKGIEKGMEKGMEKGIEKGRMDVAKRMLEKGYDVPTICELTGLPVEVVEKLKE
>NZ_AP022557.1|WP_033842957.1|2583834_2585178_-|6-phospho-beta-glucosidase
MDKRLKIATIGGGSSYTPELVEGLIKRYHELPVGELWLVDIPEGKEKLEIVGALAKRMVEKAGVPIEIHLTLDRRRALEGADFVTTQFRVGGLEARAKDERIPLKYGVIGQETNGPGGLFKGLRTIPVILDIIRDMEELCPDAWLINFTNPAGMVTEAVLRYTKQEKVVGLCNVPIGMRMGVAKLLGVDADRVHIDFAGLNHMVFGLHVYLDGVEVTDKVIDLVAHPDRSGVTMKNIVDLGWEPDFLKGLNVLPCPYHRYYFQTDKMLAEELEAAKTKGTRAEVVQQLEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACSLISSIYNDKRDIQPVNTRNNGAIASIPPESAVEVNCVITKDGPKPIAVGDLPVAVRGLVQQIKSFERVAAEAAVTGDYQTALVAMTINPLVPSDTIAKQMLDEMLEAHKEDLPQFFKQTKTAAGR
>NZ_AP022557.1|WP_033842956.1|2585302_2586070_+|MurR/RpiR-family-transcriptional-regulator
MFTPEQIAQFSELDYAIYDYVMKHPHEVAYMRIRELAEAVHVSPPTVLRFCKKVGCDGFSEFKTKWKLYLRENERTSIISSQEALREFFERTLTADYERTILDAAAAIARADHVIFVGSGSSGILAEYGSRYFSAFQKFSVYIKDPFFPIYGHYFHNCAVIALSVSGETPHTLAQVHRLKEKGSTIISITNRKHCSLANISDYNLTYYATAERIGQTDVTTQLPVIYLLERLAKEMYRLLGRETETIGKDSNPTV
>NZ_AP022557.1|WP_081130697.1|2589251_2590625_-|IS1380-family-transposase
MKDFPIRFVLTDEAITPSAGLALVGYLLHRTKLDKRVNALRLPTVRREVHISHSDVIRSMIGLLATGKTDFDHIEAYRQDDIFSASMGIQHVPSSPTLRQRLDQLACLPMTEAIIWEESMRLLVRQHATLSPCWTKGKTTWLPLDVDGSPFDNSDTKKEGVSRTYKGFDGFTPLFAYAGKEGYIVHAELRPGKQHVQDNMPSFLTTAIRRARPLTSSRLLVRMDAGNDAEANVHVCLKEDVDFVIKRNLRRESKALWFQIASQKGRRIDDGQTEGVQTYELCLPQKVAIDGNTYTYVQVTQVTERTMERNGQLMLVPNYEVESYWVRLEGYEHVRMSDVLALYHDHATCEQFHSELKSDLDLERLPSGKMKTNAIVLVMGAFVYNLLRLIGQDLLSDPRHPLHHKVKRRRIKTIIQTVITMAGLLVRRSRQIWMKLTRRSGYSEPLLNVYQKWREAR
>NZ_AP022557.1|WP_033842954.1|2590825_2592193_-|FAD-binding-protein
MGVYESLLELIGDRERVSQNETVLEHHSKGIAYHAPRQPDVVVFPKTAEEVSRVLAFANEHRIPVTPFGAGTSLEGHVIPVEGGISLDMTQMNHIVDIRSDDFLAIVEPGVTRLQLNQALKPYGLFFPVDPGADATIGGMAATNASGTNSVKYGVMRDHVLGLDVVLADGSVIQTGSLAVKSSAGYHLTGLFVGSEGTLGIFTRLIVRLHGIPEATTAIKACFPTLEAAAQAAFAVLKAGVEPGKIELVDEATIAAVNAYKKTDYPVKPTLFIELSGSRASVDDGTELVKELCESEGAVSFVVETDSLARAKLWEARHHAAFAIQAAYPGKAMLSTDVCVPLSELPGAIADTRRLVNEQNMTAAIFGHVGDGNYHTVLAFDPNDAEEMARIEQVHAHIVRYALSRGGTCTGEHGIGIGKRTFLREEKGDAVGWMKRLKQLFDPNGILNPGKIFLP
>NZ_AP022557.1|WP_033842953.1|2592271_2593249_-|alpha-ketoacid-dehydrogenase-subunit-beta
MAELTMIEAINEAMRQEMERNSRVIVLGEDVGENGGVFRATDGLLEQFGPDRVFDTPLAESGIIGTSIGLAINGMRPIAEIQFLGFVYQAMDQLAAQAARIRFRSGGRFSCPIVVRSPYGGGVRTPELHSDALEALFTHSPGLKVVMPSNPYDAKGLLISAIRDDDPVLFLEPMKLYRAFRMEVPEEPYTIPLGQARVVKEGEDLTIITWGATVPLVAKLADEMRTKGIDAEVIDLRCLQPLDIDAILASVEKTGRVMIVHEAVKTSGFGAEVAALISERALFVLSAPIVRVAGYDTPYPVPSVEDDWLPNPARITEGIETLLRY
>NZ_AP022557.1|WP_033842952.1|2593249_2594329_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MFDPNELSIEMVQILDEHGNGDEQKLAAFSDGWLLDAYRAMRRARVIDERLLRMQRQGRIGTYAPFSGQEAAQVGSALALRNDDWIFPSYREVAVCLLQGMPLEQFFYYVQGRLSGKRMPDGVNIFPTQIIIAAQTLHAVGCAWASKLKGEPHVSVAYFGDGATSEGDFHEAMNFAAVYNVPVIFFCQNNQYAISVPYAKQTASRTIAQKALAYGMKGVLVDGNDVLAVYETMRQAVDAARRGEGPMLIEALTYRLGPHTTADDPTKYRRPEEVEAWRRKDPLHRVRVLLARRGLWTEAQEEAFVAEVNAEVTAAYEAAIASPSGSIADVFDHVYSEAPKLLAEQKVEVMRRKQAKGVK
>NZ_AP022557.1|WP_033842951.1|2594404_2595697_-|2-oxo-acid-dehydrogenase-subunit-E2
MIYEFKLPDIGEGLHEAEIIRWLVREGDVVNADQPIAEIQTDKAMVEMTTPVAGKVVALAGPEGATVKVGEPLIVVEIEAAVAGEAAPTEDSVREPVPAARGEAPRPARKRAIAAPSVRKRARELGVPINEVEGTGEGGRVTLADLERYVREREAAATVAARDEAKKDTLLTGGAAEGQQASIATWTSIAGLDTLFEEEERVPLRGLRKKIAEKMVKSVYTAPHATGMDEIDVTKLVEIRKSLASELAKEQIKLTYLPFIIKAVTRALKEYPMFNAVLDEETNEIVLKKRYHIGIATATKAGLLVPVIRDADQKSIRELAVEIAELSEKAHRQALRLEELQGSTFTITSTGAGGGWFATPIINYPEVAIFGAHAIKRKPVVIDDEIVIRDMMGISLTFDHRVIDGEPAGRFMRTVAHYLSHPEVLLLDVR
>NZ_AP022557.1|WP_033842950.1|2596236_2596437_-|hypothetical-protein
MKKNYIAFFAFLVCLLYMSWLKEGWKGVPLLFLKGVVIFITIYIVVFVIVWSTMKLVGFLKDVYSD

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Crispr_ID: NZ_AP022557_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_23

3241815-3243110

TypeIII

Consensus_repeat	Method
GTTTTTATCGTACCTATGAGGGATTGAAAC	PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRT

19 spacers

csm6,csx1,cmr1gr7,cas10,cmr3gr5,cmr4gr7,cmr5gr11,cmr6gr7,cas8b1,cas7

The CRISPR arrays of NZ_AP022557_23

>merge|NZ_AP022557|23|3241815-3243110|PILER-CR,CRISPRCasFinder,CRT
GTTTTTATCGTACCTATGAGGGATTGAAACATGTGTAGGAGGTAATGAACAATGCCAATTAACTATGCGTTTTTATCGTACCTATGAGGGATTGAAACATATCTACAAATATCTGATGTTCGCATATCGAGCGGTTTTTATCGTACCTATGAGGGATTGAAACATAAAAACTAAAGGAGGCATCACTATGAACACTGTTCGTTTTTATCGTACCTATGAGGGATTGAAACTATAATAATCACAGAAACTACATAGGAGGGTGATTCGGTTTTTATCGTACCTATGAGGGATTGAAACAACGCTTCAAAGACAAAGCGGAAGCTATTGAACGTTGTTTTTATCGTACCTATGAGGGATTGAAACTTCATTCACGAAGGGCGATACCACATTGTCGAGGTTGACGTTTTTATCGTACCTATGAGGGATTGAAACAAGTGCAATATTTCATTAGGCATGAGCTTCCGTCTCTGTTTTTATCGTACCTATGAGGGATTGAAACTGCTGCAAGTTTCCTTGCAACCGGCCAAATATCTTCGTTTTTATCGTACCTATGAGGGATTGAAACATCGTGACGAGTACCATGTCGCCATCTTTCACTTGTGTTTTTATCGTACCTATGAGGGATTGAAACAGGGATCGCTCCCTTTATCGCCGGCATGAATGCATGTTTTTATCGTACCTATGAGGGATTGAAACACGTTTCGCGACTTGATTAAAGGGATTTTGCACGGTGTTTTTATCGTACCTATGAGGGATTGAAACCGTCGTGGGCAACGTCGATGCAAGCGATCGGGAACCAGTTTTTATCGTACCTATGAGGGATTGAAACAAGGGAATTGAAGCCTCATCGAAAATAAGGAGAGCGTTTTTATCGTACCTATGAGGGATTGAAACCATTGTGCTAGAGCTAGCCGCTCCATTGACCGCCCGTTTTTATCGTACCTATGAGGGATTGAAACTTAAAAAGGAGGGAACATATCAGCAAGTTATTGAGGTTTTTATCGTACCTATGAGGGATTGAAACTCCTAGTCTTCCACTGCGATAATATTTAAATGAATAAGTTTTTATCGTACCTATGAGGGATTGAAACACAAGGAGGAACAAGTCTTCTTTCGGTTTCCCGTCCGTTTTTATCGTACCTATGAGGGATTGAAACTCACAAGACTTGAAACCGTTTGACACCGACAACCTGACCGGGTTTTTATCGTACCTATGAGGGATTGAAACTAGTAAAGCCCAACACCGCACCGACAAAAGTAGACACAGTTTTTATCGTACCTATGAGAGATCGGAAC

>NZ_AP022557|23|1|3241815-3243042|PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATGTGTAGGAGGTAATGAACAATGCCAATTAACTATGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATATCTACAAATATCTGATGTTCGCATATCGAGCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAAAAACTAAAGGAGGCATCACTATGAACACTGTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TATAATAATCACAGAAACTACATAGGAGGGTGATTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACGCTTCAAAGACAAAGCGGAAGCTATTGAACGTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCATTCACGAAGGGCGATACCACATTGTCGAGGTTGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGTGCAATATTTCATTAGGCATGAGCTTCCGTCTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTGCAAGTTTCCTTGCAACCGGCCAAATATCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATCGTGACGAGTACCATGTCGCCATCTTTCACTTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGGATCGCTCCCTTTATCGCCGGCATGAATGCAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGTTTCGCGACTTGATTAAAGGGATTTTGCACGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGTCGTGGGCAACGTCGATGCAAGCGATCGGGAACCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGGGAATTGAAGCCTCATCGAAAATAAGGAGAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CATTGTGCTAGAGCTAGCCGCTCCATTGACCGCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTAAAAAGGAGGGAACATATCAGCAAGTTATTGAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCTAGTCTTCCACTGCGATAATATTTAAATGAATAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACAAGGAGGAACAAGTCTTCTTTCGGTTTCCCGTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCACAAGACTTGAAACCGTTTGACACCGACAACCTGACCGG
GTTTTTATCGTACCTATGAGGGATTGAAAC

>NZ_AP022557|23|23|3241815-3243110|CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATGTGTAGGAGGTAATGAACAATGCCAATTAACTATGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATATCTACAAATATCTGATGTTCGCATATCGAGCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAAAAACTAAAGGAGGCATCACTATGAACACTGTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TATAATAATCACAGAAACTACATAGGAGGGTGATTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACGCTTCAAAGACAAAGCGGAAGCTATTGAACGTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCATTCACGAAGGGCGATACCACATTGTCGAGGTTGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGTGCAATATTTCATTAGGCATGAGCTTCCGTCTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTGCAAGTTTCCTTGCAACCGGCCAAATATCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATCGTGACGAGTACCATGTCGCCATCTTTCACTTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGGATCGCTCCCTTTATCGCCGGCATGAATGCAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGTTTCGCGACTTGATTAAAGGGATTTTGCACGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGTCGTGGGCAACGTCGATGCAAGCGATCGGGAACCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGGGAATTGAAGCCTCATCGAAAATAAGGAGAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CATTGTGCTAGAGCTAGCCGCTCCATTGACCGCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTAAAAAGGAGGGAACATATCAGCAAGTTATTGAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCTAGTCTTCCACTGCGATAATATTTAAATGAATAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACAAGGAGGAACAAGTCTTCTTTCGGTTTCCCGTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCACAAGACTTGAAACCGTTTGACACCGACAACCTGACCGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAGTAAAGCCCAACACCGCACCGACAAAAGTAGACACA
GTTTTTATCGTACCTATGAGAGATCGGAAC

>NZ_AP022557|23|1|3241815-3243110|CRT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATGTGTAGGAGGTAATGAACAATGCCAATTAACTATGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATATCTACAAATATCTGATGTTCGCATATCGAGCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAAAAACTAAAGGAGGCATCACTATGAACACTGTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TATAATAATCACAGAAACTACATAGGAGGGTGATTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACGCTTCAAAGACAAAGCGGAAGCTATTGAACGTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCATTCACGAAGGGCGATACCACATTGTCGAGGTTGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGTGCAATATTTCATTAGGCATGAGCTTCCGTCTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTGCAAGTTTCCTTGCAACCGGCCAAATATCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATCGTGACGAGTACCATGTCGCCATCTTTCACTTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGGATCGCTCCCTTTATCGCCGGCATGAATGCAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGTTTCGCGACTTGATTAAAGGGATTTTGCACGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGTCGTGGGCAACGTCGATGCAAGCGATCGGGAACCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGGGAATTGAAGCCTCATCGAAAATAAGGAGAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CATTGTGCTAGAGCTAGCCGCTCCATTGACCGCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTAAAAAGGAGGGAACATATCAGCAAGTTATTGAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCTAGTCTTCCACTGCGATAATATTTAAATGAATAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACAAGGAGGAACAAGTCTTCTTTCGGTTTCCCGTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCACAAGACTTGAAACCGTTTGACACCGACAACCTGACCGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAGTAAAGCCCAACACCGCACCGACAAAAGTAGACACA
GTTTTTATCGTACCTATGAGAGATCGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033022462.1\|3251058_3251469_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
NZ_AP022557.1\|WP_033844709.1\|3236139_3240258_+\|TIGR02680-family-protein	unknown	unknown	gnl\|CDD\|274256
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	gnl\|CDD\|187821
NZ_AP022557.1\|WP_033842539.1\|3245138_3246464_+\|TIGR02221-family-CRISPR-associated-protein	csx1	cd09732_csx1_CAS-III	gnl\|CDD\|378186
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	gnl\|CDD\|378190
NZ_AP022557.1\|WP_108209764.1\|3246474_3247383_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|224286
NZ_AP022557.1\|WP_033022461.1\|3250149_3251043_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NZ_AP022557.1\|WP_033842554.1\|3227136_3227814_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	gnl\|CDD\|213662
NZ_AP022557.1\|WP_033022457.1\|3247379_3249023_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
NZ_AP022557.1\|WP_033842546.1\|3234982_3236140_+\|TIGR02678-family-protein	unknown	unknown	gnl\|CDD\|274254
NZ_AP022557.1\|WP_033842542.1\|3243933_3245136_+\|putative-CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NZ_AP022557.1\|WP_033842548.1\|3233487_3234999_+\|TIGR02677-family-protein	unknown	unknown	gnl\|CDD\|131724
NZ_AP022557.1\|WP_033842558.1\|3225700_3226066_+\|DUF5367-domain-containing-protein	unknown	unknown	gnl\|CDD\|340045
NZ_AP022557.1\|WP_033842544.1\|3240254_3241475_+\|TIGR02679-family-protein	unknown	unknown	gnl\|CDD\|274255
NZ_AP022557.1\|WP_033842553.1\|3227852_3229043_+\|erythromycin-esterase-family-protein	unknown	unknown	gnl\|CDD\|350610
NZ_AP022557.1\|WP_033842552.1\|3229043_3229673_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_AP022557.1\|WP_033022459.1\|3249019_3250150_+\|CRISPR-associated-protein-Cmr3	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NZ_AP022557.1\|WP_033842551.1\|3230289_3231417_-\|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224050
NZ_AP022557.1\|WP_033842550.1\|3232776_3233340_-\|coiled-coil-protein	unknown	unknown	gnl\|CDD\|224117

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033022462.1\|3251058_3251469_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	2.26889e-33
NZ_AP022557.1\|WP_033844709.1\|3236139_3240258_+\|TIGR02680-family-protein	gnl\|CDD\|274256	TIGR02680, conserved_hypothetical_protein, TIGR02680 family protein. Members of this protein family belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). Proteins in this family average over 1400 amino acids in length. [Hypothetical proteins, Conserved].	0
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl\|CDD\|187821	cd09690, Cas7_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csh2 family.	2.01193e-93
NZ_AP022557.1\|WP_033842539.1\|3245138_3246464_+\|TIGR02221-family-CRISPR-associated-protein	gnl\|CDD\|378186	pfam09455, Cas_DxTHG, CRISPR-associated (Cas) DxTHG family. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	1.34141e-67
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	6.29452e-158
NZ_AP022557.1\|WP_108209764.1\|3246474_3247383_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl\|CDD\|224286	COG1367, COG1367, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	5.98e-07
NZ_AP022557.1\|WP_033022461.1\|3250149_3251043_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	4.94887e-70
NZ_AP022557.1\|WP_033842554.1\|3227136_3227814_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	1.96675e-17
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	8.82685e-42
NZ_AP022557.1\|WP_033022457.1\|3247379_3249023_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	4.13579e-80
NZ_AP022557.1\|WP_033842546.1\|3234982_3236140_+\|TIGR02678-family-protein	gnl\|CDD\|274254	TIGR02678, hypothetical_protein, TIGR02678 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	1.3875e-133
NZ_AP022557.1\|WP_033842542.1\|3243933_3245136_+\|putative-CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	5.18828e-14
NZ_AP022557.1\|WP_033842548.1\|3233487_3234999_+\|TIGR02677-family-protein	gnl\|CDD\|131724	TIGR02677, conserved_hypothetical_protein, TIGR02677 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	0
NZ_AP022557.1\|WP_033842558.1\|3225700_3226066_+\|DUF5367-domain-containing-protein	gnl\|CDD\|340045	pfam17329, DUF5367, Family of unknown function (DUF5367). This bacterial family of proteins of unknown function is predicted to contain 3 or 4 trans-membrane regions.	7.88869e-25
NZ_AP022557.1\|WP_033842544.1\|3240254_3241475_+\|TIGR02679-family-protein	gnl\|CDD\|274255	TIGR02679, conserved_hypothetical_protein, TIGR02679 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	2.32984e-125
NZ_AP022557.1\|WP_033842553.1\|3227852_3229043_+\|erythromycin-esterase-family-protein	gnl\|CDD\|350610	cd14728, Ere-like, Erythromycin esterase and succinoglycan biosynthesis related proteins. This group contains erythromycin esterase, which shares conserved active site residues of the Tiki/TraB family. Erythromycin esterases (EreA and EreB) disrupt erythromycin via the hydrolysis of the macrolactone ring. A critical catalytic histidine acts as a general base in the activation of a water molecule. Macrolides act by inhibiting bacterial protein synthesis by binding at the exit tunnel of ribosomal subunit 50s, blocking the translation of the polypeptide. Erythromycin esterase, typically found in integrons and transposons, confers antibiotic resistance through the disruption of the drug ring structure. EreB substrate profile is substantially broader than that for EreA, being able to also metabolize semisynthetic derivatives such as azalide azithromycin.	1.35469e-54
NZ_AP022557.1\|WP_033842552.1\|3229043_3229673_-\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	4.01162e-79
NZ_AP022557.1\|WP_033022459.1\|3249019_3250150_+\|CRISPR-associated-protein-Cmr3	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.56446e-40
NZ_AP022557.1\|WP_033842551.1\|3230289_3231417_-\|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	2.48756e-160
NZ_AP022557.1\|WP_033842550.1\|3232776_3233340_-\|coiled-coil-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	6.43098e-08

>NZ_AP022557.1|WP_033842544.1|3240254_3241475_+|TIGR02679-family-protein
MNRAEEAAAFFRSELGFHRLFVEMKRKYESLGRVGGVVSLASFSENEREAIAAFFGRDVSRVSLPAFERQLERTRFAGVGLIELLEHYFGEPLVPKKEQRQAAEKERERFFGHLAHEHPWLEDICGQRFIQAAYEANREELAAAIRLVGAALRRLPLGSYERLPLFAQRIAGDPHAFDLSTLPGKVLLSALQATVLGEWDVTSVESVNELLQSVGLLREDILNFATCANLLAETKKGPHPVFTAAVEANSALNAPLRDVLSLIRAYPANGGIVYVVENAGVFSTLLDTHAPLVCTNGQMNLATMRLLDLLAASGAKLHYSGDFDPEGLKMADRFLERYGSVAVLWRYSVDDYFAANPSVHLPPERLAKLASVASAPLQPVKEAMAKTEKAGYQEAIISRLLGDIKS
>NZ_AP022557.1|WP_033844709.1|3236139_3240258_+|TIGR02680-family-protein
MADRWMLHRAGLINFWYYDEQYFHFADGKLFLRGSNGAGKSVTMQSLIPVLLDGKKTPDRLDPFGSRARRMEDYLLGEKDVVNRDERTGYLFLEYKRTETDQYLTTGIGLRAKRQKNLDFWGFVILDNRRIGHDVDLYKKEKTGEKIPLTKRELADALGAGGTVVETQKEYMELVNKHVFRFESLEAFQELIELLIQLRSPKLSKDFKPTVIYEILESALPPLTDEELRHLSETIENMDQAKQQLEQLERDARALKRLCDYYRHYNEYMIAEKAVEYEKAVQRAEQLAAEQRTRSEEENKARQRLDELDEEITRLSREEDVLRAREVELAGHEVFQQAETYEKLKEQQRDLARRRERQERVIEEKERLERQRRHQIDEAEARLDELERKVEETLAQLRADADEGAFAGHEVNEDDFLRHHRQQREFPFTIWKQEADRHAERLEALADLWRRHEGLQARYEEASKEAGELQREVDEWRHQYRKWDELLDQEKERWEQAVLVWLERGGVTVDEARIQTFLRQTDGLYDQYSIDDLKQPFTAAYYDAVGKKNDEKWRLEHEMRLLGDQLAEREQELRHWQTEQDPEPERDPQTDAMRAELERQGVVSVPLYAAVEFFDHVPEPVRERIESALAHAGLLDALIIDRDVAVTYDRVLVPNPVHMAHTLADYLQPDAGVPVAAERIDAVLRSIVIADEAQDGGMTLNEAGRYALGLVRGHAPTRERAMFIGRTARRRWRMEKIASLEEEIASLRQALDRLQAEHKAVEAHIAALAEWFAAFPSDRDVRAAFEEREEARRRAESKERDWQRQQEKVSRLAREWQHLKQTLREQSAGLDVAFSVEGCDRARLAMKSYLRFLHELEVHVREALYVAAMITQQREQLQELRDDIDEAKGERNRLLDEDERLALRMAEIERTLQQMGADDIRAEIARVRERLNTLREAVPLLVNERARTEQRLARLAEEREQGEKRATFARELAAAWEQAFAREAALKLVELDRSRPLREQASEAKQRYGGTLKDSRSSLLARLNTIFFQESSNLNEYRATFESLPFEEKEWSTVAPDDEMAMKAKDWREKQERNVIFLDYKGQRATPSVVLAEVEREIALQHEYMKEQDRELYEEVILKSVGRILRSRIQRAERWVNDMNKRMSEIDTSSSLVLSIQWKPKTAETEDELDTKELVGLLRMDSRLLKEEDLQRVTNHFRSKIARARELLEERGQGNTLHQIIKEVLDYRKWFSFTLYYEKEHEPKRELTNQRFYRFSGGEKALAMYIPLFAAAYSRYQEAGDDAPYIISLDEAFAGVDENNIRMMFGLVEQLGFNYIMNSQALWGDYDTVPALSICELVRPRNAPFVTVIQYYWNGRIKQLVANEEEWELIET
>NZ_AP022557.1|WP_033842546.1|3234982_3236140_+|TIGR02678-family-protein
MEASFDDKAKEALAALFEQFWIVRDADPERYQLVREREHVLKRYVEEKFGYRLIVHRHFAKLEKIPAEPEPWMGIPSFQEPLDYALFCCLMAYVESKAVEEKFLLSDVCEEIRSMYPGDVPVDWTNYSQRRALIRVLKAAEQIGLIRRMDGEIEAFAQHADEEALYEVPVLARYFMRTYPKDLLQYTSIDELLAEEWKAAPQDYRRHRLYRKLFLSPAVHRTEGDEQDFYYLRNFRHRLREDIESHTPFRYELYKNVAMLTIPERQAPYTLFPDLKGTSDIILHFAAVVRERLASFPPDEYGRLWLTPAQFSEWLADTKRRYGAGWGKTHREASLAELAREVLAELEAWRMADTDPETGMVVLYPLLGRLCGRYPDDFQAKEREL
>NZ_AP022557.1|WP_033842548.1|3233487_3234999_+|TIGR02677-family-protein
MDASWLKPIVETKYLSAENAHRYRAILRYFYIQHERMRQYLFPEEVYAFLKQHNEFADYTEDELQQDLDQLVKWNNLIARQETSHIRTIEEFKKKRFRYQCSPYTVEIERMIRTLEQLGDSFGGSLEKTRFDRLYASLSRMETIISANFQEKPDEIHQVWEETFDYFKKIIHHSADYIAYLHSENLEERMTAESFLVYKEQFTAYLRDFIVALQKTSMQIERLLEDLPDEGVDRFIEHVVDYERSIPRFAESAPSRAECIEEKRETWRSLREWFLGRDGHESELAFLQHQTNEAIRRLTRIVQRLGERHHHFRSRKGDYLHLARWFSQLSSIEEAHCLSAVVFGCFHTKHLIADNEATDDMYRDVWEEAPMEWVTKPRVRHYGEKKKPQAIEEKKREKEEARRRYLEEKAREEAELKQLVKDGKIVLAELGEVTPYVRKTLLAWIAKAMGKEQPTVKTENGWDIRIVRRDDTICLHAEDGTLVMPNYEIEVMAKGGSEDGGVV
>NZ_AP022557.1|WP_033842550.1|3232776_3233340_-|coiled-coil-protein
MEALLREILHEVKATRAAVESLERRVGALEGQVAQLNERTTALETQVTQLNERTTALETQVAQLNERSSALEQQFAQLNERTSALEQQFAQLNERTTTLEQRIDLLYERTTETKAIAEALRHGQEVLTAKYEAMANDLHQMKGDLTHVTSILEDKVLPALAEHEAGLHVLNARVFRTESILHRLVHA
>NZ_AP022557.1|WP_033842551.1|3230289_3231417_-|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein
MIRFENVTKQYEDGFVALKTINLEIHKGELVALIGPSGCGKTTTMRMINRLIEPTSGTVYIDGQDISTLDPVELRRNIGYVIQQIGLFPHMTIAENIALVPKLKKWEKSAYEKRVDELLDLVGLDPATFKHRYPSELSGGQQQRVGVVRALAAEPNIILMDEPFSALDPISREQLQDDIVRLQEEIRKTIVFVTHDMDEAIKIADRIALMKDGEVVQFATPDQMLRRPANSFVREFIGEDRLLTRQTAVPTAEDLMSDAVATIAPRRGLAEAFRLMKARKVDSLVVVDKKQSFLGIVTLKQIEQRYNEEHLLVADIADYDVTTLQKEADVTDVAALFQDPDVRIIPVLDGDRLVGGITRSSMMRALAEWTFQQHA
>NZ_AP022557.1|WP_033842552.1|3229043_3229673_-|ABC-transporter-permease
MELLRTFIERREEIWIAFQEHVLLSAIAMGIAIAVAVPIGVVLTRYRKLAEPIIGIAAIIQTIPSLALLGFMLPIFGIGKLPAIIALTLYALLPILRNTYTGILGVDPALVDAGRGMGMTSRQILWMVELPLSLPVIMAGVRTATVLTIGVAALATFIGAGGLGDLIDRGLRIADKNLILAGAIPAAILAIAFDWLLRKVEKKVTPKGL
>NZ_AP022557.1|WP_033842553.1|3227852_3229043_+|erythromycin-esterase-family-protein
MITFFIDEVKHQSIDIGDMDRYHFEFLQPILEHKRFVFLGESSHCVKEYSLAKVSLIKYLHEELGFHVLAFESELGPCMIGDYLSDQLDSKRFMVGTIGRAWQNEFVLGLFDYMKKMKQERPLYFTGVDVYQGKKENLFSEFLESYLTGPTKQKFVDFEKRAIEVLIAADKRKIKRSMRQNIREEMESKGMELIEELKQHCFPDSKIYKIVLRTMENRVNYLKANLEKSFSKLFEYRDALMAKNLEFLAQEIYPNEKFIIWAHNMHISKNTSAKRLSAYKSFVENLSQTIKEKSFVLGLYAKEGKMLDYTGKEYPIKKMNKKHLESLLDHSPYQNSFIQCNGNWAQKKWRAYEGGGMPTSFVPAQQYDGILFFKSVSPAYFFDVSETTERGKKPKG
>NZ_AP022557.1|WP_033842554.1|3227136_3227814_+|VanZ-family-protein
MIRKTVTVIPFVMVACLKTWDHVYGNFPGISVWIVFIHICLNLLPIFVFVCWSVSKVRQWSGMNMVIHACFYVYLFFVLYYTVLYIPYWRFMTQPVLPLEEQVFPHYNFIPLKTILETSITPVNIWGNILLLLPLGIFVPLIHPYFARIKPFLLFALLVSSGIESVQFLTALMDGKFAEYPSERSFDVDDIILNVSGAVIGFSLYQLWGRMKSLISRSHRSSPNR
>NZ_AP022557.1|WP_033842558.1|3225700_3226066_+|DUF5367-domain-containing-protein
MYFLIWGFLVWLGATIIFRFFGHFFFNPENALLLLLSYLLVVPLIFLLTYPLYKLKGLKKDERLKAAMFIALPGMFIDTIVLVIFPEVFTNLLVESDRYFGSWLLWAYSLILITGLSPRKE
>NZ_AP022557.1|WP_033842542.1|3243933_3245136_+|putative-CRISPR-associated-protein
MYQHIVLTCGVSLLTGARNVFSVNRDETLGEIRSWIHDRDVDEQKQSKIGRWLRHARQFAHEAAQQPNRVCAEYSMIYELHRQGKLGERPTIVLIVTDTVGGRVVEAMLVHLLERDFKANVRVVYVEVDVNHRRRLQETLGEYMSKVANALMHGEPSTTCFAPIGGYKVMTSLGYIVGAFLNYPTAYMHEDGQVLHEIPPVPIHIDEQFVRRYFELLRKCQMDLVAMNELSYQEKQCIEQYPSLFYRDAEFVCLSAFGQFLLEHEKYKHLFETSYFVSRQVADMLRHNRHQSLFVYQQMQELVKKLKYREGDASVLYHEKSFETIDPRKAKYHLYKGASNGQTAFRLAYRYVEEEDRLYANYLWLDHDRYEREAVRGKGIYEDDSSFSDVTAQLVGTGGS
>NZ_AP022557.1|WP_033842539.1|3245138_3246464_+|TIGR02221-family-CRISPR-associated-protein
MGRHVLLSFLGLSDYEYCFYTYEGKTSSYTRFVQTAVYELLRGEQPMDVIVFATKEARERNGEDRLRGEEQLEGLMTAFRRIAPEANVKMVDIDNGQDERTNWRLFDRIMSEIGEGDTIYFDITHSFRSIPFVALIVLNYARLVKKAEIGAIVYGWFEVLGRPMDVKQMPPEERLAPIVNLTSMASLLDWTNGVDQFLRTGDAALIRALTEKENRHVFCDPTASRELRNEVAALNKLAKQLDQTEKAIRTCRSLDIDEEVRKFREQLARVRSAPTEAVKPLVPLLDEMEKKYAIFSDDPIINSWQAVRWCLNHGLIQSALTMLEENAVTAICRAFSLDERKEEVRKDIHSTIQIVLRRIPRDEWRVHSPELVERMANALDSYREELKPFGQIKELRNDINHAGTRPNPLPAEKFMPKAVALFEQFSSFFERMSMLAKSMSK
>NZ_AP022557.1|WP_108209764.1|3246474_3247383_+|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MMERYESATATAVVESPYQLVLLTPAAIHGAEPRAQAEFRLPSLRGVWRYFWRTLQDQPNVNDLLREEEIMFGGTRVMKQQSPVHLSMSETVQGAKKENILPHKSSSFTVPALSAGKEVTVTISVRKRHESKLEMYEWYFQYMLHLAGIGQRSRRGFGAVQWTGHEWNTVEEYADSLHAVLSRLGVASAFSFASRGCIVSRAAAVKTPHPILSAVWVGEGKDSASEVLKGFGKASHEANRYGTLGFVQGKNKLASPLWCTVRKIGGRYYPIISEVRTNEQRYNEPRYEQDRKRFLEIVGVRV
>NZ_AP022557.1|WP_033022457.1|3247379_3249023_+|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MTNRYIVLFTVGPVQSFIASARKTEDFWSGSYILSHLVREAMKRFYQYGTGCEMIYPLVGKEELRALSLRELRVASLPNRLTAVMEGTEADICGWLQETEQGVRNVFLDFCFQALSRMFPHLSDDERQQLEAMVEQQVQSFLEVYWVAEPYEPSASFRTVRERAERRLGALKNEKHYASVPQQGLVCSVCKEREALRLEEIDDFDRYGEIKRKTANLWRRRAGKFQGRDGDGEDERRVGRVKDNEFLCGICLGKRVARDYFTDLFGAAFRPFPSVLDIGSGDYYAVLMMDGDNMGRWFSGEQKEEYSRTSQKLARFSKEVVPRIVEQQCHGELVYAGGDDVLAFLPVDEALKAAELLRLAFSDEQQGLGEGATASFGLVIAHKKAPLQHVLNEARMLEQKAKQYRNEQTNQQKDALALAVYTRSGEIAEAILPWMIKGKMASSRLEQFVALLKTSISPNFIFHFTQAFAPLLHDKDCPKWENRDMLAVELRRLLKRSVKEGNQWKERDLRSHTDALMALYDAVPSGYDFLHLLKMLTFFRRSEGSDV
>NZ_AP022557.1|WP_033022459.1|3249019_3250150_+|CRISPR-associated-protein-Cmr3
MTKLTLRPTDTFFFKNHHATQAGETTVMEPMFPPRPNTIYGALRAAYIYTHSSFEDFARGADEHVKQWMGTPNERGAFRLHYCGLADGDQLFLPLPLDYQVVEEGESLTAYPLELVKDRKPASSSLGWRLASSRREKTKSSQHRYVSVDEWKRALLASQPITSLRSLSSFIAREAKVGIQLDDSKRTAREKFLYRVEKSRFLGDASLVAYISDEPDFSAVKWARIGGENRPWSIRQTPGQFRLWSVDERRAVEQAIQRTKLAKVVFLSPAIFSNGSRPATFDGVHWRWPNGATVEWLASAIGRPELYGGWDIVHHRPKPRKWMVPAGSVVYVKVERDEELPLIFSALDGIHLTDEEAEEGFGFAIVTSASESEEEL
>NZ_AP022557.1|WP_033022461.1|3250149_3251043_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MYSIVRPFVLHAVTSVHAGSGSEIGLVDLPIQREKHTGFPKIESSSLKGAVRYHMMQALPEEKKELDLIFGADRGEERVTQASAIALSDARVLLFPVKSLRGVFAWITCPHVLERWNQEMSIHQETISQENAFQPLPVPAPNTVSSDRLMAVNGRIVLEEYTFDVTISREAQQLAEQLAALIGEYSRLRLPERLVVLSDDDFADFVKLSTEVNARIRISHKTGTVDNGALWYEENVPPETFFYSFLYIGHARGNGINGLTAANDIEQYLVKSGKFPSVFQLGGNSTLGRGMMRTIWL
>NZ_AP022557.1|WP_033022462.1|3251058_3251469_+|type-III-B-CRISPR-module-associated-protein-Cmr5
MKKTVQRVGIENGRAAFAFQEVKRAKEQLRENFETYRSYVKKMPSLIQVNGLGQTLAFYFQKKKQNEYKVIYHTLAQWMKEQFPDQFSSGNEELVEVVVHLSSAEYRLWTMEAVALLDWMRKFADGMAKDDGGTAE
>NZ_AP022557.1|WP_033022463.1|3251481_3252627_+|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MLFHPKDTRDVMQAASKSMAHLAYHLYYFLEHEWNDKKRVWELSKRLKPAPVLPELKEVGEQLRAQREHALAAWAQTGHVKKLKARLAGRIIHGLGAGHVRETSLTIHPVYGLPYIPASSVKGLVRHWWIEAYGQGEEKSLSEQKNGRDVFGTQEKKGMVQFHDIFLIDGLQLVRDVLAVHMKEYYEGKKAATDDQKPVPVSFWTVTAAEVEIYLTANRSAQNDEEAKRLLEEAAAWTKAALTEWGIGSKTSSGYGRFIDVEDVTETEFLPVVRKETMRLEQRKKEQALLEQRKREEEEQAKLALLSPEERLVAEIVQLTDSQADQQRSKDALYNQVIQQQNKQAAQALLAYWQRIGQWGKSASKKQKEKINVLQQLLNGS
>NZ_AP022557.1|WP_033022465.1|3256651_3258367_+|TIGR02556-family-CRISPR-associated-protein
MIEAIAQIGKIVLEKQGEGSVVDQLVENPGYPACVLVAVRADEEGNVVWEGCEIEECGSDYKKYLFRSGSSRGTNYSPTAKITTIENTYEQKVIGWFRTVTRKMDHPVLRAIEQLLVQKKEAILQELREKLSLLTDRSLISLKMNGSYLYDCEPFRDAFLHLVHEKDMELSARDQVCAICGERKDTVIGKLSVFRFYTLDKPGFITGGFDEAKAWRNYPVCLSCKAHIEEGRKFVESHLHYRFYGFSYFVIPTLLIPAGKDVLDELLQYLTDGKKDIRVHQEQADSFMTTEEDLLGLMQDYDNSLSLQLLFLQKIQSAERILLLIEDVLPSRISELFQAKKATESLLYREGDHPFHFGFLRTFFRSGVYDKYFLQVVEYVFQKKPLSISFFAPFFMEQLRADFYDYEAGDWSFVNKTRQALAVVLFLEQAGVLVRKGEKAVQGKFAQLFDAYGGQLESPEKQAVFLLGALTQMLLDIQQQKRGSKPFVKQLMGLKMDEKAIKGLLPKVIGKLEEYESYYASHRQLAEEISHLFLSSSPSWKLSVDELNFYFACGMNLSWKVKEIVANKEEK
>NZ_AP022557.1|WP_033022466.1|3258368_3259325_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MVKHRSELLFLYDVQWANPNGDPVDGNKPRIDEETGKNIVTDVRLKRTIRDYLYDYRQQEIFVREIAQDDEYIQDAKARAEDFLVKDGEKLDKSKLTLREMKKIINDEVLRQCIDVRLFGVTLPIEKNQKEKSSITHTGPVQFKMGQSLHRVKMEYIKGTGAFASGGQMTQKTFREEYVLPYSLIAFYGIINEAAARFTGLTEEDVELLMEAMWEGTKNLISRSKVGHVPRLLLRVAYQEPYFHIGELDKYISLHTEKAEEEIRDVSDYVLDVSRLVEVLVQQKEHIANIELRQDGRLACSENLAERLRKEGITVDIR

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Crispr_ID: NZ_AP022557_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_24

3252814-3255158

TypeIII

Consensus_repeat	Method
GTTTTTATCGTACCTATGAGGGATTGAAAC	PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRT

35 spacers

cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7,csx1,csm6,cas8b1,cas7,cas5,cas3,cas4,cas1,cas2,cas6

The CRISPR arrays of NZ_AP022557_24

>merge|NZ_AP022557|24|3252814-3255158|PILER-CR,CRISPRCasFinder,CRT
GTTTTTATCGTACCTATGAGGGATTGAAACACCTACCGCGTCTGAATACTCGATTTGGTGAAGCTCCGTTTTTATCGTACCTATGAGGGATTGAAACAGTCTTGTTGCGCTTCGATTGTCCAAGTAGCTTTGGTTTTTATCGTACCTATGAGGGATTGAAACCTCCCAAAGTTCTTCCTCCTTCACGCATATCGCCAGTTTTTATCGTACCTATGAGGGATTGAAACGGTGTTTGTATTGGTCGTTTTCTTGTTCCATCCGTTGTTTTTATCGTACCTATGAGGGATTGAAACATAAAAACTAAAGGAGGCATCACTATGAACACTGTTCGTTTTTATCGTACCTATGAGGGATTGAAACTATAATAATCACAGAAACTACATAGGAGGGTGATTCGGTTTTTATCGTACCTATGAGGGATTGAAACAACGCTTCAAAGACAAAGCGGAAGCTATTGAACGTTGTTTTTATCGTACCTATGAGGGATTGAAACTTCATTCACGAAGGGCGATACCACATTGTCGAGGTTGACGTTTTTATCGTACCTATGAGGGATTGAAACAAGTGCAATATTTCATTAGGCATGAGCTTCCGTCTCTGTTTTTATCGTACCTATGAGGGATTGAAACTGCTGCAAGTTTCCTTGCAACCGGCCAAATATCTTCGTTTTTATCGTACCTATGAGGGATTGAAACATCGTGACGAGTACCATGTCGCCATCTTTCACTTGTGTTTTTATCGTACCTATGAGGGATTGAAACAGGGATCGCTCCCTTTATCGCCGGCATGAATGCATGTTTTTATCGTACCTATGAGGGATTGAAACACGTTTCGCGACTTGATTAAAGGGATTTTGCACGGTGTTTTTATCGTACCTATGAGGGATTGAAACCACGAGCGTTTTTCTCGCCATTGACGACATTGATTGTTTTTATCGTACCTATGAGGGATTGAAACTTTCCCCACGGTTGTTTTCCGTGGGGCTGAAATTCCGTTTTTATCGTACCTATGAGGGATTGAAACTAGTATGAAAAATCGTCACTTTCAAGGGGGAGGGGTGTTTTTATCGTACCTATGAGGGATTGAAACAATTGTCATACAAATCTCTCCTTTTCATGATTGATTGTTTTTATCGTACCTATGAGGGATTGAAACTACAGCACTTTTTCCGGCATCGCATGATGGAACACGTTTTTATCGTACCTATGAGGGATTGAAACTTCTTTTGCTTGTTTGCGTTCTAGCCATTTAGTGTAGTGTTTTTATCGTACCTATGAGGGATTGAAACTTTCACTTCTCGCGGTGTACGTACTAGGGTTAAAGTTTTTATCGTACCTATGAGGGATTGAAACTTTCAAGATCTGTAAAGTCAGCTAATTGCATTAGCGTTTTTATCGTACCTATGAGGGATTGAAACTTATTGCGCTTCTCCATATCCATTGTATTAATTCGGAGTTTTTATCGTACCTATGAGGGATTGAAACTTTATTTTCCTCCTTTTGTTTTTTCTAATTATATTGGTTTTTATCGTACCTATGAGGGATTGAAACTGAACGCGAAGCGCAAAGAGCAAGCCAAAGCAGAGCGTTTTTATCGTACCTATGAGGGATTGAAACAATCATCCTCCCTATTTAATTTTCAATGTTCAATTGAGTTTTTATCGTACCTATGAGGGATTGAAACCCAGCAAATTTTTTCATGAAATTGTTGCATTTTGTCGTTTTTATCGTACCTATGAGGGATTGAAACTGCGTCGGAGCTGTGGCACAGTGACGGCGAGTAGCGTTTTTATCGTACCTATGAGGGATTGAAACTCTAATCCGTATAGATAAATTGTGAAATCATCTTTCGTTTTTATCGTACCTATGAGGGATTGAAACGGTTCGTTCAAAATTAACTGGACTGTCCCCGGAAGGTTTTTATCGTACCTATGAGGGATTGAAACCGGTAAACCTCGACGCGGTATTCGGGGAATTCGTTTTCGTTTTTATCGTACCTATGAGGGATTGAAACATTGTATGTGTTTCTGTTTTTTTGCTGGTTTTTGTGTTTTTATCGTACCTATGAGGGATTGAAACTGCTAAGAGCACGATGATCTGGGATAAGCTCGTGACGTTTTTATCGTACCTATGAGGGATTGAAACATTCCCTAATCAAGTTCCGCCAGCCGTTTTGGATGTTGGTTTTTATCGTACCTATGAGGGATTGAAACCCCGATCCGCTTTAATACCAGTCATTGCGTCAGCCGGTTTTTATCGTACCTATGAGGGATTGAAACAATACATCGCCGTGCGGGCGCGGAAGGTGGCGTAGTCGTTTTTATCGCACTTATGACGAATTTTTCA

>NZ_AP022557|24|2|3252814-3255091|PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCTACCGCGTCTGAATACTCGATTTGGTGAAGCTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGTCTTGTTGCGCTTCGATTGTCCAAGTAGCTTTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTCCCAAAGTTCTTCCTCCTTCACGCATATCGCCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGTGTTTGTATTGGTCGTTTTCTTGTTCCATCCGTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAAAAACTAAAGGAGGCATCACTATGAACACTGTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TATAATAATCACAGAAACTACATAGGAGGGTGATTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACGCTTCAAAGACAAAGCGGAAGCTATTGAACGTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCATTCACGAAGGGCGATACCACATTGTCGAGGTTGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGTGCAATATTTCATTAGGCATGAGCTTCCGTCTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTGCAAGTTTCCTTGCAACCGGCCAAATATCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATCGTGACGAGTACCATGTCGCCATCTTTCACTTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGGATCGCTCCCTTTATCGCCGGCATGAATGCAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGTTTCGCGACTTGATTAAAGGGATTTTGCACGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGAGCGTTTTTCTCGCCATTGACGACATTGATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCCCCACGGTTGTTTTCCGTGGGGCTGAAATTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAGTATGAAAAATCGTCACTTTCAAGGGGGAGGGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATTGTCATACAAATCTCTCCTTTTCATGATTGATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TACAGCACTTTTTCCGGCATCGCATGATGGAACAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCTTTTGCTTGTTTGCGTTCTAGCCATTTAGTGTAGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCACTTCTCGCGGTGTACGTACTAGGGTTAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCAAGATCTGTAAAGTCAGCTAATTGCATTAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTATTGCGCTTCTCCATATCCATTGTATTAATTCGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTATTTTCCTCCTTTTGTTTTTTCTAATTATATTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGAACGCGAAGCGCAAAGAGCAAGCCAAAGCAGAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATCATCCTCCCTATTTAATTTTCAATGTTCAATTGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCAGCAAATTTTTTCATGAAATTGTTGCATTTTGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCGTCGGAGCTGTGGCACAGTGACGGCGAGTAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTAATCCGTATAGATAAATTGTGAAATCATCTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGTTCGTTCAAAATTAACTGGACTGTCCCCGGAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGGTAAACCTCGACGCGGTATTCGGGGAATTCGTTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTGTATGTGTTTCTGTTTTTTTGCTGGTTTTTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTAAGAGCACGATGATCTGGGATAAGCTCGTGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTCCCTAATCAAGTTCCGCCAGCCGTTTTGGATGTTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCCGATCCGCTTTAATACCAGTCATTGCGTCAGCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC

>NZ_AP022557|24|24|3252814-3255158|CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCTACCGCGTCTGAATACTCGATTTGGTGAAGCTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGTCTTGTTGCGCTTCGATTGTCCAAGTAGCTTTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTCCCAAAGTTCTTCCTCCTTCACGCATATCGCCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGTGTTTGTATTGGTCGTTTTCTTGTTCCATCCGTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAAAAACTAAAGGAGGCATCACTATGAACACTGTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TATAATAATCACAGAAACTACATAGGAGGGTGATTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACGCTTCAAAGACAAAGCGGAAGCTATTGAACGTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCATTCACGAAGGGCGATACCACATTGTCGAGGTTGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGTGCAATATTTCATTAGGCATGAGCTTCCGTCTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTGCAAGTTTCCTTGCAACCGGCCAAATATCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATCGTGACGAGTACCATGTCGCCATCTTTCACTTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGGATCGCTCCCTTTATCGCCGGCATGAATGCAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGTTTCGCGACTTGATTAAAGGGATTTTGCACGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGAGCGTTTTTCTCGCCATTGACGACATTGATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCCCCACGGTTGTTTTCCGTGGGGCTGAAATTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAGTATGAAAAATCGTCACTTTCAAGGGGGAGGGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATTGTCATACAAATCTCTCCTTTTCATGATTGATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TACAGCACTTTTTCCGGCATCGCATGATGGAACAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCTTTTGCTTGTTTGCGTTCTAGCCATTTAGTGTAGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCACTTCTCGCGGTGTACGTACTAGGGTTAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCAAGATCTGTAAAGTCAGCTAATTGCATTAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTATTGCGCTTCTCCATATCCATTGTATTAATTCGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTATTTTCCTCCTTTTGTTTTTTCTAATTATATTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGAACGCGAAGCGCAAAGAGCAAGCCAAAGCAGAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATCATCCTCCCTATTTAATTTTCAATGTTCAATTGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCAGCAAATTTTTTCATGAAATTGTTGCATTTTGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCGTCGGAGCTGTGGCACAGTGACGGCGAGTAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTAATCCGTATAGATAAATTGTGAAATCATCTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGTTCGTTCAAAATTAACTGGACTGTCCCCGGAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGGTAAACCTCGACGCGGTATTCGGGGAATTCGTTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTGTATGTGTTTCTGTTTTTTTGCTGGTTTTTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTAAGAGCACGATGATCTGGGATAAGCTCGTGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTCCCTAATCAAGTTCCGCCAGCCGTTTTGGATGTTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCCGATCCGCTTTAATACCAGTCATTGCGTCAGCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATACATCGCCGTGCGGGCGCGGAAGGTGGCGTAGTC
GTTTTTATCGCACTTATGACGAATTTTTCA

>NZ_AP022557|24|2|3252814-3255158|CRT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCTACCGCGTCTGAATACTCGATTTGGTGAAGCTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGTCTTGTTGCGCTTCGATTGTCCAAGTAGCTTTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTCCCAAAGTTCTTCCTCCTTCACGCATATCGCCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGTGTTTGTATTGGTCGTTTTCTTGTTCCATCCGTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAAAAACTAAAGGAGGCATCACTATGAACACTGTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TATAATAATCACAGAAACTACATAGGAGGGTGATTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACGCTTCAAAGACAAAGCGGAAGCTATTGAACGTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCATTCACGAAGGGCGATACCACATTGTCGAGGTTGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGTGCAATATTTCATTAGGCATGAGCTTCCGTCTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTGCAAGTTTCCTTGCAACCGGCCAAATATCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATCGTGACGAGTACCATGTCGCCATCTTTCACTTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGGATCGCTCCCTTTATCGCCGGCATGAATGCAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGTTTCGCGACTTGATTAAAGGGATTTTGCACGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGAGCGTTTTTCTCGCCATTGACGACATTGATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCCCCACGGTTGTTTTCCGTGGGGCTGAAATTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAGTATGAAAAATCGTCACTTTCAAGGGGGAGGGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATTGTCATACAAATCTCTCCTTTTCATGATTGATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TACAGCACTTTTTCCGGCATCGCATGATGGAACAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCTTTTGCTTGTTTGCGTTCTAGCCATTTAGTGTAGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCACTTCTCGCGGTGTACGTACTAGGGTTAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCAAGATCTGTAAAGTCAGCTAATTGCATTAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTATTGCGCTTCTCCATATCCATTGTATTAATTCGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTATTTTCCTCCTTTTGTTTTTTCTAATTATATTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGAACGCGAAGCGCAAAGAGCAAGCCAAAGCAGAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATCATCCTCCCTATTTAATTTTCAATGTTCAATTGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCAGCAAATTTTTTCATGAAATTGTTGCATTTTGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCGTCGGAGCTGTGGCACAGTGACGGCGAGTAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTAATCCGTATAGATAAATTGTGAAATCATCTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGTTCGTTCAAAATTAACTGGACTGTCCCCGGAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGGTAAACCTCGACGCGGTATTCGGGGAATTCGTTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTGTATGTGTTTCTGTTTTTTTGCTGGTTTTTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTAAGAGCACGATGATCTGGGATAAGCTCGTGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTCCCTAATCAAGTTCCGCCAGCCGTTTTGGATGTTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCCGATCCGCTTTAATACCAGTCATTGCGTCAGCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATACATCGCCGTGCGGGCGCGGAAGGTGGCGTAGTC
GTTTTTATCGCACTTATGACGAATTTTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033022482.1\|3262940_3263942_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NZ_AP022557.1\|WP_033842532.1\|3267278_3268187_+\|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl\|CDD\|273806
NZ_AP022557.1\|WP_033842534.1\|3264387_3265134_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_AP022557.1\|WP_033842542.1\|3243933_3245136_+\|putative-CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NZ_AP022557.1\|WP_172418743.1\|3263953_3264217_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	gnl\|CDD\|213662
NZ_AP022557.1\|WP_033842531.1\|3269041_3270178_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_108209764.1\|3246474_3247383_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|224286
NZ_AP022557.1\|WP_033022467.1\|3259340_3260084_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_AP022557.1\|WP_033022461.1\|3250149_3251043_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NZ_AP022557.1\|WP_033842539.1\|3245138_3246464_+\|TIGR02221-family-CRISPR-associated-protein	csx1	cd09732_csx1_CAS-III	gnl\|CDD\|378186
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	gnl\|CDD\|187821
NZ_AP022557.1\|WP_033022457.1\|3247379_3249023_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
NZ_AP022557.1\|WP_033022476.1\|3262428_3262938_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_AP022557.1\|WP_033844709.1\|3236139_3240258_+\|TIGR02680-family-protein	unknown	unknown	gnl\|CDD\|274256
NZ_AP022557.1\|WP_033842544.1\|3240254_3241475_+\|TIGR02679-family-protein	unknown	unknown	gnl\|CDD\|274255
NZ_AP022557.1\|WP_033022462.1\|3251058_3251469_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	gnl\|CDD\|378190
NZ_AP022557.1\|WP_033022459.1\|3249019_3250150_+\|CRISPR-associated-protein-Cmr3	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NZ_AP022557.1\|WP_033022473.1\|3260085_3262419_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP022557.1\|WP_033022482.1\|3262940_3263942_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	1.3e-139	459.6	8.2
NZ_AP022557.1\|WP_033842534.1\|3264387_3265134_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	4.2e-41	136.1	0.0
NZ_AP022557.1\|WP_033022473.1\|3260085_3262419_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	1.9e-55	183.1	0.2
NZ_AP022557.1\|WP_172418743.1\|3263953_3264217_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	1.8e-29	96.7	0.3
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	8.4e-42	138.2	2.5
NZ_AP022557.1\|WP_108209764.1\|3246474_3247383_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	1.3e-12	42.1	1.6
NZ_AP022557.1\|WP_033022467.1\|3259340_3260084_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-39	130.6	0.0
NZ_AP022557.1\|WP_033022461.1\|3250149_3251043_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	7.6e-72	237.0	0.0
NZ_AP022557.1\|WP_033842539.1\|3245138_3246464_+\|TIGR02221-family-CRISPR-associated-protein	csx1	cd09732_csx1_CAS-III	3.7e-72	238.2	0.0
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	3.2e-95	313.4	1.3
NZ_AP022557.1\|WP_033022457.1\|3247379_3249023_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	1.2e-80	266.4	0.1
NZ_AP022557.1\|WP_033022476.1\|3262428_3262938_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	8e-54	176.9	0.1
NZ_AP022557.1\|WP_033842542.1\|3243933_3245136_+\|putative-CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	8.4e-24	78.6	0.0
NZ_AP022557.1\|WP_033022462.1\|3251058_3251469_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	2e-33	110.0	1.1
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	2.2e-112	371.4	0.0
NZ_AP022557.1\|WP_033022459.1\|3249019_3250150_+\|CRISPR-associated-protein-Cmr3	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	1.9e-55	183.6	0.1

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033022482.1\|3262940_3263942_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	6.10823e-172
NZ_AP022557.1\|WP_033842532.1\|3267278_3268187_+\|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	2.6243e-10
NZ_AP022557.1\|WP_033842534.1\|3264387_3265134_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.04048e-33
NZ_AP022557.1\|WP_033842542.1\|3243933_3245136_+\|putative-CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	5.18828e-14
NZ_AP022557.1\|WP_172418743.1\|3263953_3264217_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	9.67307e-33
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	8.82685e-42
NZ_AP022557.1\|WP_033842531.1\|3269041_3270178_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_108209764.1\|3246474_3247383_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl\|CDD\|224286	COG1367, COG1367, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	5.98e-07
NZ_AP022557.1\|WP_033022467.1\|3259340_3260084_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	6.43974e-33
NZ_AP022557.1\|WP_033022461.1\|3250149_3251043_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	4.94887e-70
NZ_AP022557.1\|WP_033842539.1\|3245138_3246464_+\|TIGR02221-family-CRISPR-associated-protein	gnl\|CDD\|378186	pfam09455, Cas_DxTHG, CRISPR-associated (Cas) DxTHG family. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	1.34141e-67
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl\|CDD\|187821	cd09690, Cas7_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csh2 family.	2.01193e-93
NZ_AP022557.1\|WP_033022457.1\|3247379_3249023_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	4.13579e-80
NZ_AP022557.1\|WP_033022476.1\|3262428_3262938_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.21924e-73
NZ_AP022557.1\|WP_033844709.1\|3236139_3240258_+\|TIGR02680-family-protein	gnl\|CDD\|274256	TIGR02680, conserved_hypothetical_protein, TIGR02680 family protein. Members of this protein family belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). Proteins in this family average over 1400 amino acids in length. [Hypothetical proteins, Conserved].	0
NZ_AP022557.1\|WP_033842544.1\|3240254_3241475_+\|TIGR02679-family-protein	gnl\|CDD\|274255	TIGR02679, conserved_hypothetical_protein, TIGR02679 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	2.32984e-125
NZ_AP022557.1\|WP_033022462.1\|3251058_3251469_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	2.26889e-33
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	6.29452e-158
NZ_AP022557.1\|WP_033022459.1\|3249019_3250150_+\|CRISPR-associated-protein-Cmr3	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.56446e-40
NZ_AP022557.1\|WP_033022473.1\|3260085_3262419_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	5.68476e-45

>NZ_AP022557.1|WP_033022463.1|3251481_3252627_+|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MLFHPKDTRDVMQAASKSMAHLAYHLYYFLEHEWNDKKRVWELSKRLKPAPVLPELKEVGEQLRAQREHALAAWAQTGHVKKLKARLAGRIIHGLGAGHVRETSLTIHPVYGLPYIPASSVKGLVRHWWIEAYGQGEEKSLSEQKNGRDVFGTQEKKGMVQFHDIFLIDGLQLVRDVLAVHMKEYYEGKKAATDDQKPVPVSFWTVTAAEVEIYLTANRSAQNDEEAKRLLEEAAAWTKAALTEWGIGSKTSSGYGRFIDVEDVTETEFLPVVRKETMRLEQRKKEQALLEQRKREEEEQAKLALLSPEERLVAEIVQLTDSQADQQRSKDALYNQVIQQQNKQAAQALLAYWQRIGQWGKSASKKQKEKINVLQQLLNGS
>NZ_AP022557.1|WP_033022462.1|3251058_3251469_+|type-III-B-CRISPR-module-associated-protein-Cmr5
MKKTVQRVGIENGRAAFAFQEVKRAKEQLRENFETYRSYVKKMPSLIQVNGLGQTLAFYFQKKKQNEYKVIYHTLAQWMKEQFPDQFSSGNEELVEVVVHLSSAEYRLWTMEAVALLDWMRKFADGMAKDDGGTAE
>NZ_AP022557.1|WP_033022461.1|3250149_3251043_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MYSIVRPFVLHAVTSVHAGSGSEIGLVDLPIQREKHTGFPKIESSSLKGAVRYHMMQALPEEKKELDLIFGADRGEERVTQASAIALSDARVLLFPVKSLRGVFAWITCPHVLERWNQEMSIHQETISQENAFQPLPVPAPNTVSSDRLMAVNGRIVLEEYTFDVTISREAQQLAEQLAALIGEYSRLRLPERLVVLSDDDFADFVKLSTEVNARIRISHKTGTVDNGALWYEENVPPETFFYSFLYIGHARGNGINGLTAANDIEQYLVKSGKFPSVFQLGGNSTLGRGMMRTIWL
>NZ_AP022557.1|WP_033022459.1|3249019_3250150_+|CRISPR-associated-protein-Cmr3
MTKLTLRPTDTFFFKNHHATQAGETTVMEPMFPPRPNTIYGALRAAYIYTHSSFEDFARGADEHVKQWMGTPNERGAFRLHYCGLADGDQLFLPLPLDYQVVEEGESLTAYPLELVKDRKPASSSLGWRLASSRREKTKSSQHRYVSVDEWKRALLASQPITSLRSLSSFIAREAKVGIQLDDSKRTAREKFLYRVEKSRFLGDASLVAYISDEPDFSAVKWARIGGENRPWSIRQTPGQFRLWSVDERRAVEQAIQRTKLAKVVFLSPAIFSNGSRPATFDGVHWRWPNGATVEWLASAIGRPELYGGWDIVHHRPKPRKWMVPAGSVVYVKVERDEELPLIFSALDGIHLTDEEAEEGFGFAIVTSASESEEEL
>NZ_AP022557.1|WP_033022457.1|3247379_3249023_+|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MTNRYIVLFTVGPVQSFIASARKTEDFWSGSYILSHLVREAMKRFYQYGTGCEMIYPLVGKEELRALSLRELRVASLPNRLTAVMEGTEADICGWLQETEQGVRNVFLDFCFQALSRMFPHLSDDERQQLEAMVEQQVQSFLEVYWVAEPYEPSASFRTVRERAERRLGALKNEKHYASVPQQGLVCSVCKEREALRLEEIDDFDRYGEIKRKTANLWRRRAGKFQGRDGDGEDERRVGRVKDNEFLCGICLGKRVARDYFTDLFGAAFRPFPSVLDIGSGDYYAVLMMDGDNMGRWFSGEQKEEYSRTSQKLARFSKEVVPRIVEQQCHGELVYAGGDDVLAFLPVDEALKAAELLRLAFSDEQQGLGEGATASFGLVIAHKKAPLQHVLNEARMLEQKAKQYRNEQTNQQKDALALAVYTRSGEIAEAILPWMIKGKMASSRLEQFVALLKTSISPNFIFHFTQAFAPLLHDKDCPKWENRDMLAVELRRLLKRSVKEGNQWKERDLRSHTDALMALYDAVPSGYDFLHLLKMLTFFRRSEGSDV
>NZ_AP022557.1|WP_108209764.1|3246474_3247383_+|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MMERYESATATAVVESPYQLVLLTPAAIHGAEPRAQAEFRLPSLRGVWRYFWRTLQDQPNVNDLLREEEIMFGGTRVMKQQSPVHLSMSETVQGAKKENILPHKSSSFTVPALSAGKEVTVTISVRKRHESKLEMYEWYFQYMLHLAGIGQRSRRGFGAVQWTGHEWNTVEEYADSLHAVLSRLGVASAFSFASRGCIVSRAAAVKTPHPILSAVWVGEGKDSASEVLKGFGKASHEANRYGTLGFVQGKNKLASPLWCTVRKIGGRYYPIISEVRTNEQRYNEPRYEQDRKRFLEIVGVRV
>NZ_AP022557.1|WP_033842539.1|3245138_3246464_+|TIGR02221-family-CRISPR-associated-protein
MGRHVLLSFLGLSDYEYCFYTYEGKTSSYTRFVQTAVYELLRGEQPMDVIVFATKEARERNGEDRLRGEEQLEGLMTAFRRIAPEANVKMVDIDNGQDERTNWRLFDRIMSEIGEGDTIYFDITHSFRSIPFVALIVLNYARLVKKAEIGAIVYGWFEVLGRPMDVKQMPPEERLAPIVNLTSMASLLDWTNGVDQFLRTGDAALIRALTEKENRHVFCDPTASRELRNEVAALNKLAKQLDQTEKAIRTCRSLDIDEEVRKFREQLARVRSAPTEAVKPLVPLLDEMEKKYAIFSDDPIINSWQAVRWCLNHGLIQSALTMLEENAVTAICRAFSLDERKEEVRKDIHSTIQIVLRRIPRDEWRVHSPELVERMANALDSYREELKPFGQIKELRNDINHAGTRPNPLPAEKFMPKAVALFEQFSSFFERMSMLAKSMSK
>NZ_AP022557.1|WP_033842542.1|3243933_3245136_+|putative-CRISPR-associated-protein
MYQHIVLTCGVSLLTGARNVFSVNRDETLGEIRSWIHDRDVDEQKQSKIGRWLRHARQFAHEAAQQPNRVCAEYSMIYELHRQGKLGERPTIVLIVTDTVGGRVVEAMLVHLLERDFKANVRVVYVEVDVNHRRRLQETLGEYMSKVANALMHGEPSTTCFAPIGGYKVMTSLGYIVGAFLNYPTAYMHEDGQVLHEIPPVPIHIDEQFVRRYFELLRKCQMDLVAMNELSYQEKQCIEQYPSLFYRDAEFVCLSAFGQFLLEHEKYKHLFETSYFVSRQVADMLRHNRHQSLFVYQQMQELVKKLKYREGDASVLYHEKSFETIDPRKAKYHLYKGASNGQTAFRLAYRYVEEEDRLYANYLWLDHDRYEREAVRGKGIYEDDSSFSDVTAQLVGTGGS
>NZ_AP022557.1|WP_033842544.1|3240254_3241475_+|TIGR02679-family-protein
MNRAEEAAAFFRSELGFHRLFVEMKRKYESLGRVGGVVSLASFSENEREAIAAFFGRDVSRVSLPAFERQLERTRFAGVGLIELLEHYFGEPLVPKKEQRQAAEKERERFFGHLAHEHPWLEDICGQRFIQAAYEANREELAAAIRLVGAALRRLPLGSYERLPLFAQRIAGDPHAFDLSTLPGKVLLSALQATVLGEWDVTSVESVNELLQSVGLLREDILNFATCANLLAETKKGPHPVFTAAVEANSALNAPLRDVLSLIRAYPANGGIVYVVENAGVFSTLLDTHAPLVCTNGQMNLATMRLLDLLAASGAKLHYSGDFDPEGLKMADRFLERYGSVAVLWRYSVDDYFAANPSVHLPPERLAKLASVASAPLQPVKEAMAKTEKAGYQEAIISRLLGDIKS
>NZ_AP022557.1|WP_033844709.1|3236139_3240258_+|TIGR02680-family-protein
MADRWMLHRAGLINFWYYDEQYFHFADGKLFLRGSNGAGKSVTMQSLIPVLLDGKKTPDRLDPFGSRARRMEDYLLGEKDVVNRDERTGYLFLEYKRTETDQYLTTGIGLRAKRQKNLDFWGFVILDNRRIGHDVDLYKKEKTGEKIPLTKRELADALGAGGTVVETQKEYMELVNKHVFRFESLEAFQELIELLIQLRSPKLSKDFKPTVIYEILESALPPLTDEELRHLSETIENMDQAKQQLEQLERDARALKRLCDYYRHYNEYMIAEKAVEYEKAVQRAEQLAAEQRTRSEEENKARQRLDELDEEITRLSREEDVLRAREVELAGHEVFQQAETYEKLKEQQRDLARRRERQERVIEEKERLERQRRHQIDEAEARLDELERKVEETLAQLRADADEGAFAGHEVNEDDFLRHHRQQREFPFTIWKQEADRHAERLEALADLWRRHEGLQARYEEASKEAGELQREVDEWRHQYRKWDELLDQEKERWEQAVLVWLERGGVTVDEARIQTFLRQTDGLYDQYSIDDLKQPFTAAYYDAVGKKNDEKWRLEHEMRLLGDQLAEREQELRHWQTEQDPEPERDPQTDAMRAELERQGVVSVPLYAAVEFFDHVPEPVRERIESALAHAGLLDALIIDRDVAVTYDRVLVPNPVHMAHTLADYLQPDAGVPVAAERIDAVLRSIVIADEAQDGGMTLNEAGRYALGLVRGHAPTRERAMFIGRTARRRWRMEKIASLEEEIASLRQALDRLQAEHKAVEAHIAALAEWFAAFPSDRDVRAAFEEREEARRRAESKERDWQRQQEKVSRLAREWQHLKQTLREQSAGLDVAFSVEGCDRARLAMKSYLRFLHELEVHVREALYVAAMITQQREQLQELRDDIDEAKGERNRLLDEDERLALRMAEIERTLQQMGADDIRAEIARVRERLNTLREAVPLLVNERARTEQRLARLAEEREQGEKRATFARELAAAWEQAFAREAALKLVELDRSRPLREQASEAKQRYGGTLKDSRSSLLARLNTIFFQESSNLNEYRATFESLPFEEKEWSTVAPDDEMAMKAKDWREKQERNVIFLDYKGQRATPSVVLAEVEREIALQHEYMKEQDRELYEEVILKSVGRILRSRIQRAERWVNDMNKRMSEIDTSSSLVLSIQWKPKTAETEDELDTKELVGLLRMDSRLLKEEDLQRVTNHFRSKIARARELLEERGQGNTLHQIIKEVLDYRKWFSFTLYYEKEHEPKRELTNQRFYRFSGGEKALAMYIPLFAAAYSRYQEAGDDAPYIISLDEAFAGVDENNIRMMFGLVEQLGFNYIMNSQALWGDYDTVPALSICELVRPRNAPFVTVIQYYWNGRIKQLVANEEEWELIET
>NZ_AP022557.1|WP_033022465.1|3256651_3258367_+|TIGR02556-family-CRISPR-associated-protein
MIEAIAQIGKIVLEKQGEGSVVDQLVENPGYPACVLVAVRADEEGNVVWEGCEIEECGSDYKKYLFRSGSSRGTNYSPTAKITTIENTYEQKVIGWFRTVTRKMDHPVLRAIEQLLVQKKEAILQELREKLSLLTDRSLISLKMNGSYLYDCEPFRDAFLHLVHEKDMELSARDQVCAICGERKDTVIGKLSVFRFYTLDKPGFITGGFDEAKAWRNYPVCLSCKAHIEEGRKFVESHLHYRFYGFSYFVIPTLLIPAGKDVLDELLQYLTDGKKDIRVHQEQADSFMTTEEDLLGLMQDYDNSLSLQLLFLQKIQSAERILLLIEDVLPSRISELFQAKKATESLLYREGDHPFHFGFLRTFFRSGVYDKYFLQVVEYVFQKKPLSISFFAPFFMEQLRADFYDYEAGDWSFVNKTRQALAVVLFLEQAGVLVRKGEKAVQGKFAQLFDAYGGQLESPEKQAVFLLGALTQMLLDIQQQKRGSKPFVKQLMGLKMDEKAIKGLLPKVIGKLEEYESYYASHRQLAEEISHLFLSSSPSWKLSVDELNFYFACGMNLSWKVKEIVANKEEK
>NZ_AP022557.1|WP_033022466.1|3258368_3259325_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MVKHRSELLFLYDVQWANPNGDPVDGNKPRIDEETGKNIVTDVRLKRTIRDYLYDYRQQEIFVREIAQDDEYIQDAKARAEDFLVKDGEKLDKSKLTLREMKKIINDEVLRQCIDVRLFGVTLPIEKNQKEKSSITHTGPVQFKMGQSLHRVKMEYIKGTGAFASGGQMTQKTFREEYVLPYSLIAFYGIINEAAARFTGLTEEDVELLMEAMWEGTKNLISRSKVGHVPRLLLRVAYQEPYFHIGELDKYISLHTEKAEEEIRDVSDYVLDVSRLVEVLVQQKEHIANIELRQDGRLACSENLAERLRKEGITVDIR
>NZ_AP022557.1|WP_033022467.1|3259340_3260084_+|type-I-B-CRISPR-associated-protein-Cas5
MNVLVFDVRADFGHFRQMYSTSSPLTYSFIPPTALFGLLGAIVGVGKEDNDYLRVFNHETTNVAVRLMEPVRKTRVGINYVNTKGNIWVPKQRREGARTQIRVEFLRFPRFRCYVYMNDHERFSQLVDFVRQHKSVYTPCLGLSECLADVQFVAVDDFHRVEAIDKEPVPICSVIPGRDIQALKVEPGKEYRKERVAWEMDPARVVSRYEEVIFEAGARPLLASVPYYWQNAQGERIVFFYSNGKGE
>NZ_AP022557.1|WP_033022473.1|3260085_3262419_+|CRISPR-associated-helicase/endonuclease-Cas3
MYSHPHYFLSDHLRGVEQLSSLFLSEKSVRLAESGQLAEVNRWIALFHDIGKSHAFFQRYIQSPDSFQDPPALKSHALLSAVLLAVFLQEKGMDEFWRLLAFLVVKRHHGNLDDWLEELKRMGDEAKTLLKRQAEATDFSALSKQMACLGVGQEAIWTKEVWLAWIERFFAEARSLRRWIMKWNRSNDSLVPYLQLLFLFSLLIDADKSEVGILQKQSWSFSGRKDIPTDLILRYKQQQSWPKTTLNEWRERAFQEVDQAPIDLRHHVYSLNLPTGMGKTLAGLHFALRLRREIERRQRVTPRIIYSLPFLSIIDQTASVLKDVFAASGMQEDHQLWLAHHHLADMRYVTRQDEERYDADYEAAKLLVEGWHSELIVTTFVQLFETIFSHRNASLRKFHRLANSIILIDEVQAVPHRYWLAVRRLFAAMAEELGCYFIFSSATDPKWFPEAVSLVNESAYFQLLSRVTLHPDIDEPVEIEEFARQIEWDEEKTYLFILNTIESAKALYRAFLDEGVDEGDMTFLSTHIPPKERLRRIMAAKNGEYRIVVSTQLIEAGVDIDFDVVYRDFAPLDSIQQAAGRCNRHGQRGGKVHIIRLTDNKKRLYASYIYDAIRLDITQTLLKGKAKIEESEFLQLITAYFETLTARMSNNESERLLKGMMTLYFDGEETVDRLPVSRFRLIEGEGEKFNVFIELDEEASEVFREYEAILRISDRWERRKRFSDIKTRFFQYVIAIPARVDHQPPIVHGIGYVGRDSLSDFYDEALGYRTKSEGLIW
>NZ_AP022557.1|WP_033022476.1|3262428_3262938_+|CRISPR-associated-protein-Cas4
MEYEMPVTGTDIWYYYICPREVWLMKHQIAPDQEDEAIEIGRFLSETTYQRDKKEISIGSIVIDRIRQEDGQLIIGEVKKSSSYMKSARMQLLYYLDTLRQAGIYAKGELLFPKERKKERVEWTEEGRHELERAIADIRRIVRMPVPPPPKKISFCGKCAYREYCWAEE
>NZ_AP022557.1|WP_033022482.1|3262940_3263942_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTLYIFQNGELRRKDNSLYFETEGRKRYIPVENTNDIYIFGEVDVSKRFLEFAAQKEIIVHYFNHYGYYVGSFYPREHLNSGHVIVKQVEHYIDPAKRLELACLFVQGSIRQMERVLKYYRSRLSEPEELEKALQLIEREEGRLNQAETVEQLMAAEGHIREAYYASFDTIIRHPDFVFEKRTKRPPHNRLNALISFGNSIVYTMCLSEIYKTYLDPRIGFLHSTNFRRFSLNLDIAEIFKPIIVDRLIFTLVNRHMLSHKHFEKLTDGILLNEEGRKLFVSELEKKMQTTVQHRHLGKSVSYRRLIRLELYKVQKHLLGEKTYEPYVARW
>NZ_AP022557.1|WP_172418743.1|3263953_3264217_+|CRISPR-associated-endonuclease-Cas2
MFVILVYDFNEKRVAKALKIARKYLHWVQNSVFEGEITTANYEKLKMELRQLMEPDEDSVIFYTFRTQKYSKREEMGVKKGGDEFIL
>NZ_AP022557.1|WP_033842534.1|3264387_3265134_+|CRISPR-associated-endoribonuclease-Cas6
MRLTITMNGRQGPVSLPLHYQHLLQGLLYRSLESERFATFLHEIGFRHGKRSFKLFTFSRLFGKHEVDGGKKTIRFLDDFQWHIDTILPDLTEQLGQQLLLRREIWLYDQPVEVKSVKMDKVEIAQNTIEVAMLSPLTVYSTYETIDGKKKTHFFGPDDDVFPHLVELNFRHKYEAYYGVEPEERLMIEPVHVHHRHRVVTRFKDMYITGWLGHYRLSSSPEQLTFLYHVGLGSRNSQGFGMFRLISE
>NZ_AP022557.1|WP_033842532.1|3267278_3268187_+|Rpn-family-recombination-promoting-nuclease/putative-transposase
MAIDHDRLFKELIRTFFEEFLLLFFPDMHEHIDFHHLSFLSEELFTDVTAGEKYRVDLLVETKLKGEDGLIIVHVETQGYVQPSFAERMFLYFSRLYESYRTRIVPIAVFHYDSLREEPSVFSMEFPFGEVLQFRFFPVALRKKQWREYIRQDNPVAAALLSQMGYTEREKVELKKEFLRMLVRLELDEARQRLLLGFFETYVKLTEEEEQQLQSEVKAMETKEREKVLELIISYEQKGKKEGLEEGVKRGLAQGMKQGMEQGMKQGMKRLIQTMAQKGMTAAEIAQLVDLSEEEVRSLLSE
>NZ_AP022557.1|WP_033842531.1|3269041_3270178_-|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI

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Crispr_ID: NZ_AP022557_25

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_25

3265313-3267210

TypeIII

Consensus_repeat	Method
GTTTTTATCGTACCTATGAGGGATTGAAAC	PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRT

28 spacers

cas6,cas2,cas1,cas4,cas3,cas5,cas7,cas8b1,cmr6gr7,cmr5gr11,cas9

The CRISPR arrays of NZ_AP022557_25

>merge|NZ_AP022557|25|3265313-3267210|PILER-CR,CRISPRCasFinder,CRT
GTTTTTATCGTACCTATGAGGGATTGAAACTCCGAAATCGCGAAGACATATAACACAACAGTAGCACGTTTTTATCGTACCTATGAGGGATTGAAACCTTTGTGACGTCATAGTCCTCTTTCGACGCGCCTTCGTTTTTATCGTACCTATGAGGGATTGAAACTTTTCTACCGGCTCGCCTCCCACGTAATGCTCTAAAACGTTTTTATCGTACCTATGAGGGATTGAAACTACGCTATGTGTACATTGCTGTGGAAGGCAGTCCAAGTTTTTATCGTACCTATGAGGGATTGAAACTAGCTGGAACGGTACAGCATGGGTGCGTACGGGTGGCGGTTTTTATCGTACCTATGAGGGATTGAAACATTGGTGCCACTGTCGCCATCGGATGCGTAATGAAGGTTTTTATCGTACCTATGAGGGATTGAAACCACGGTGAAACCTGGAGATACACTGTCTGGAATCGCGTTTTTATCGTACCTATGAGGGATTGAAACTTGATAAGAATTTTCGAAACGCTTCCTTCCCCAGCGTTTTTATCGTACCTATGAGGGATTGAAACACGGCAACGTCATCCCATTGACGATGGCCGGTCAGGTTTTTATCGTACCTATGAGGGATTGAAACACGTCGAAGTATTGGCAAAATCAGCCGATTAAGAATTTCAGTTTTTATCGTACCTATGAGGGATTGAAACAGTGGTGGGTAGTTGACTTTCTTGCATTATCCTCGGATTTCGGTTTTTATCGTACCTATGAGGGATTGAAACAGGGGATTGCTCCCTTTATCCTCCGCCCGAATGTTCAGGTTTTTATCGTACCTATGAGGGATTGAAACCATAAATAATGCACTTTCTTTTTTTTCAGTACAATTCGTTTTTATCGTACCTATGAGGGATTGAAACATAGGTTCGGTTGTAGACTCCATAACTAAATATGCGGGTTTTTATCGTACCTATGAGGGATTGAAACAACAAACCCTCAAACGGGAATTGGAAAAGTGGTTCAAAGTTTTTATCGTACCTATGAGGGATTGAAACACTCCTTCTCGATGCAGTCCAGCACAGGTTTTCCACCGTTTTTATCGTACCTATGAGGGATTGAAACATACCGTATGTTCTTGAAGAAGTTTTTGATTTTCGTTTTTATCGTACCTATGAGGGATTGAAACTGCTCAATTTCTTTTAAGCCGTAGATTTCGTCCAGCTGTTTTTATCGTACCTATGAGGGATTGAAACCGACACAGCATGTCATCGCAACGGACGGGTATCGCGTTTTTATCGTACCTATGAGGGATTGAAACAGCCGAAGCTCTGGAAAAGTATTTGCCAGTTCCACGTTTTTATCGTACCTATGAGGGATTGAAACAAGGTGCCGCTTGTATCAAATATGAGGGACACCTAGTTTTTATCGTACCTATGAGGGATTGAAACGATGTACAAATGAAAACAAGCACAGGGACATTAACGTTTTTATCGTACCTATGAGGGATTGAAACTTTTTCCTAATCCTCCTAAAGCCGCCGGTTTCTCTTCGTTTTTATCGTACCTATGAGGGATTGAAACTGCAATGATTGGTAAAGACGCTAGAGAGATGGAGGAATGTTTTTATCGTACCTATGAGGGATTGAAACAATAATTCATAAAGGAGTGTATCAAATGAAACGCATTTAGTTTTTATCGTACCTATGAGGGATTGAAACCTCGGTTCGCCTTGCGTATTCGGTTGCCCTCCATCGTTTTTATCGTACCTATGAGGGATTGAAACTCCTTTGCTTGATATGTCCCGGCTTCTGCGTATTGGTTTTTATCGTACCTATGAGGGATTGAAACAATACATCGCCGTGCGGGCGCGGAAGGTGGCGTAGTCGTTTTTATCGCACTTATGACGAATTTTTCA

>NZ_AP022557|25|3|3265313-3267143|PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCGAAATCGCGAAGACATATAACACAACAGTAGCAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTTTGTGACGTCATAGTCCTCTTTCGACGCGCCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTTCTACCGGCTCGCCTCCCACGTAATGCTCTAAAAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TACGCTATGTGTACATTGCTGTGGAAGGCAGTCCAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAGCTGGAACGGTACAGCATGGGTGCGTACGGGTGGCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTGGTGCCACTGTCGCCATCGGATGCGTAATGAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGGTGAAACCTGGAGATACACTGTCTGGAATCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGATAAGAATTTTCGAAACGCTTCCTTCCCCAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGGCAACGTCATCCCATTGACGATGGCCGGTCAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGTCGAAGTATTGGCAAAATCAGCCGATTAAGAATTTCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGTGGTGGGTAGTTGACTTTCTTGCATTATCCTCGGATTTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGGGATTGCTCCCTTTATCCTCCGCCCGAATGTTCAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CATAAATAATGCACTTTCTTTTTTTTCAGTACAATTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAGGTTCGGTTGTAGACTCCATAACTAAATATGCGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACAAACCCTCAAACGGGAATTGGAAAAGTGGTTCAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACTCCTTCTCGATGCAGTCCAGCACAGGTTTTCCACC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATACCGTATGTTCTTGAAGAAGTTTTTGATTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTCAATTTCTTTTAAGCCGTAGATTTCGTCCAGCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGACACAGCATGTCATCGCAACGGACGGGTATCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGCCGAAGCTCTGGAAAAGTATTTGCCAGTTCCAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGGTGCCGCTTGTATCAAATATGAGGGACACCTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GATGTACAAATGAAAACAAGCACAGGGACATTAAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTTTCCTAATCCTCCTAAAGCCGCCGGTTTCTCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCAATGATTGGTAAAGACGCTAGAGAGATGGAGGAAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATAATTCATAAAGGAGTGTATCAAATGAAACGCATTTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTCGGTTCGCCTTGCGTATTCGGTTGCCCTCCATC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCTTTGCTTGATATGTCCCGGCTTCTGCGTATTG
GTTTTTATCGTACCTATGAGGGATTGAAAC

>NZ_AP022557|25|25|3265313-3267210|CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCGAAATCGCGAAGACATATAACACAACAGTAGCAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTTTGTGACGTCATAGTCCTCTTTCGACGCGCCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTTCTACCGGCTCGCCTCCCACGTAATGCTCTAAAAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TACGCTATGTGTACATTGCTGTGGAAGGCAGTCCAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAGCTGGAACGGTACAGCATGGGTGCGTACGGGTGGCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTGGTGCCACTGTCGCCATCGGATGCGTAATGAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGGTGAAACCTGGAGATACACTGTCTGGAATCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGATAAGAATTTTCGAAACGCTTCCTTCCCCAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGGCAACGTCATCCCATTGACGATGGCCGGTCAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGTCGAAGTATTGGCAAAATCAGCCGATTAAGAATTTCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGTGGTGGGTAGTTGACTTTCTTGCATTATCCTCGGATTTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGGGATTGCTCCCTTTATCCTCCGCCCGAATGTTCAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CATAAATAATGCACTTTCTTTTTTTTCAGTACAATTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAGGTTCGGTTGTAGACTCCATAACTAAATATGCGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACAAACCCTCAAACGGGAATTGGAAAAGTGGTTCAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACTCCTTCTCGATGCAGTCCAGCACAGGTTTTCCACC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATACCGTATGTTCTTGAAGAAGTTTTTGATTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTCAATTTCTTTTAAGCCGTAGATTTCGTCCAGCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGACACAGCATGTCATCGCAACGGACGGGTATCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGCCGAAGCTCTGGAAAAGTATTTGCCAGTTCCAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGGTGCCGCTTGTATCAAATATGAGGGACACCTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GATGTACAAATGAAAACAAGCACAGGGACATTAAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTTTCCTAATCCTCCTAAAGCCGCCGGTTTCTCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCAATGATTGGTAAAGACGCTAGAGAGATGGAGGAAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATAATTCATAAAGGAGTGTATCAAATGAAACGCATTTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTCGGTTCGCCTTGCGTATTCGGTTGCCCTCCATC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCTTTGCTTGATATGTCCCGGCTTCTGCGTATTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATACATCGCCGTGCGGGCGCGGAAGGTGGCGTAGTC
GTTTTTATCGCACTTATGACGAATTTTTCA

>NZ_AP022557|25|3|3265313-3267210|CRT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCGAAATCGCGAAGACATATAACACAACAGTAGCAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTTTGTGACGTCATAGTCCTCTTTCGACGCGCCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTTCTACCGGCTCGCCTCCCACGTAATGCTCTAAAAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TACGCTATGTGTACATTGCTGTGGAAGGCAGTCCAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAGCTGGAACGGTACAGCATGGGTGCGTACGGGTGGCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTGGTGCCACTGTCGCCATCGGATGCGTAATGAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGGTGAAACCTGGAGATACACTGTCTGGAATCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGATAAGAATTTTCGAAACGCTTCCTTCCCCAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGGCAACGTCATCCCATTGACGATGGCCGGTCAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGTCGAAGTATTGGCAAAATCAGCCGATTAAGAATTTCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGTGGTGGGTAGTTGACTTTCTTGCATTATCCTCGGATTTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGGGATTGCTCCCTTTATCCTCCGCCCGAATGTTCAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CATAAATAATGCACTTTCTTTTTTTTCAGTACAATTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAGGTTCGGTTGTAGACTCCATAACTAAATATGCGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACAAACCCTCAAACGGGAATTGGAAAAGTGGTTCAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACTCCTTCTCGATGCAGTCCAGCACAGGTTTTCCACC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATACCGTATGTTCTTGAAGAAGTTTTTGATTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTCAATTTCTTTTAAGCCGTAGATTTCGTCCAGCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGACACAGCATGTCATCGCAACGGACGGGTATCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGCCGAAGCTCTGGAAAAGTATTTGCCAGTTCCAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGGTGCCGCTTGTATCAAATATGAGGGACACCTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GATGTACAAATGAAAACAAGCACAGGGACATTAAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTTTCCTAATCCTCCTAAAGCCGCCGGTTTCTCTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCAATGATTGGTAAAGACGCTAGAGAGATGGAGGAAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATAATTCATAAAGGAGTGTATCAAATGAAACGCATTTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTCGGTTCGCCTTGCGTATTCGGTTGCCCTCCATC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCTTTGCTTGATATGTCCCGGCTTCTGCGTATTG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATACATCGCCGTGCGGGCGCGGAAGGTGGCGTAGTC
GTTTTTATCGCACTTATGACGAATTTTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_081897275.1\|3272616_3272880_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_AP022557.1\|WP_033845048.1\|3277285_3278341_+\|P1-family-peptidase	unknown	unknown	gnl\|CDD\|239071
NZ_AP022557.1\|WP_033842532.1\|3267278_3268187_+\|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl\|CDD\|273806
NZ_AP022557.1\|WP_033842534.1\|3264387_3265134_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_AP022557.1\|WP_033022473.1\|3260085_3262419_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	gnl\|CDD\|187821
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	gnl\|CDD\|213662
NZ_AP022557.1\|WP_033842531.1\|3269041_3270178_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_033022467.1\|3259340_3260084_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_AP022557.1\|WP_172418743.1\|3263953_3264217_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_AP022557.1\|WP_033022482.1\|3262940_3263942_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NZ_AP022557.1\|WP_033022476.1\|3262428_3262938_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_AP022557.1\|WP_033844706.1\|3278502_3279741_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340949
NZ_AP022557.1\|WP_033844703.1\|3279901_3280555_-\|PspA/IM30-family-protein	unknown	unknown	gnl\|CDD\|224755
NZ_AP022557.1\|WP_156102755.1\|3270725_3270893_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033842531.1\|3271103_3272240_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_033022462.1\|3251058_3251469_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	gnl\|CDD\|378190
NZ_AP022557.1\|WP_033844707.1\|3273713_3276977_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226044
NZ_AP022557.1\|WP_172418839.1\|3272884_3273763_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP022557.1\|WP_081897275.1\|3272616_3272880_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	1.3e-31	103.9	0.0
NZ_AP022557.1\|WP_033842534.1\|3264387_3265134_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	4.2e-41	136.1	0.0
NZ_AP022557.1\|WP_033022473.1\|3260085_3262419_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	1.9e-55	183.1	0.2
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	3.2e-95	313.4	1.3
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	8.4e-42	138.2	2.5
NZ_AP022557.1\|WP_033844707.1\|3273713_3276977_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	3.6e-215	711.9	20.5
NZ_AP022557.1\|WP_033022467.1\|3259340_3260084_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-39	130.6	0.0
NZ_AP022557.1\|WP_172418743.1\|3263953_3264217_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	1.8e-29	96.7	0.3
NZ_AP022557.1\|WP_033022482.1\|3262940_3263942_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	1.3e-139	459.6	8.2
NZ_AP022557.1\|WP_033022476.1\|3262428_3262938_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	8e-54	176.9	0.1
NZ_AP022557.1\|WP_033022462.1\|3251058_3251469_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	2e-33	110.0	1.1
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	2.2e-112	371.4	0.0
NZ_AP022557.1\|WP_172418839.1\|3272884_3273763_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	7.3e-86	282.4	0.1

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_081897275.1\|3272616_3272880_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	4.21797e-30
NZ_AP022557.1\|WP_033845048.1\|3277285_3278341_+\|P1-family-peptidase	gnl\|CDD\|239071	cd02253, DmpA, L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active heterodimeric form. The cleavage results in two polypeptide chains, with one chain containing an N-terminal nucleophile. This group represents one of the rare aminopeptidases that are not metalloenzymes. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	2.4613e-171
NZ_AP022557.1\|WP_033842532.1\|3267278_3268187_+\|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	2.6243e-10
NZ_AP022557.1\|WP_033842534.1\|3264387_3265134_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.04048e-33
NZ_AP022557.1\|WP_033022473.1\|3260085_3262419_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	5.68476e-45
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl\|CDD\|187821	cd09690, Cas7_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csh2 family.	2.01193e-93
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	8.82685e-42
NZ_AP022557.1\|WP_033842531.1\|3269041_3270178_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_033022467.1\|3259340_3260084_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	6.43974e-33
NZ_AP022557.1\|WP_172418743.1\|3263953_3264217_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	9.67307e-33
NZ_AP022557.1\|WP_033022482.1\|3262940_3263942_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	6.10823e-172
NZ_AP022557.1\|WP_033022476.1\|3262428_3262938_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.21924e-73
NZ_AP022557.1\|WP_033844706.1\|3278502_3279741_-\|MFS-transporter	gnl\|CDD\|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.21794e-110
NZ_AP022557.1\|WP_033844703.1\|3279901_3280555_-\|PspA/IM30-family-protein	gnl\|CDD\|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	3.30065e-22
NZ_AP022557.1\|WP_033842531.1\|3271103_3272240_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_033022462.1\|3251058_3251469_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	2.26889e-33
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	6.29452e-158
NZ_AP022557.1\|WP_033844707.1\|3273713_3276977_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|226044	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms].	0
NZ_AP022557.1\|WP_172418839.1\|3272884_3273763_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.61295e-95

>NZ_AP022557.1|WP_033842534.1|3264387_3265134_+|CRISPR-associated-endoribonuclease-Cas6
MRLTITMNGRQGPVSLPLHYQHLLQGLLYRSLESERFATFLHEIGFRHGKRSFKLFTFSRLFGKHEVDGGKKTIRFLDDFQWHIDTILPDLTEQLGQQLLLRREIWLYDQPVEVKSVKMDKVEIAQNTIEVAMLSPLTVYSTYETIDGKKKTHFFGPDDDVFPHLVELNFRHKYEAYYGVEPEERLMIEPVHVHHRHRVVTRFKDMYITGWLGHYRLSSSPEQLTFLYHVGLGSRNSQGFGMFRLISE
>NZ_AP022557.1|WP_172418743.1|3263953_3264217_+|CRISPR-associated-endonuclease-Cas2
MFVILVYDFNEKRVAKALKIARKYLHWVQNSVFEGEITTANYEKLKMELRQLMEPDEDSVIFYTFRTQKYSKREEMGVKKGGDEFIL
>NZ_AP022557.1|WP_033022482.1|3262940_3263942_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTLYIFQNGELRRKDNSLYFETEGRKRYIPVENTNDIYIFGEVDVSKRFLEFAAQKEIIVHYFNHYGYYVGSFYPREHLNSGHVIVKQVEHYIDPAKRLELACLFVQGSIRQMERVLKYYRSRLSEPEELEKALQLIEREEGRLNQAETVEQLMAAEGHIREAYYASFDTIIRHPDFVFEKRTKRPPHNRLNALISFGNSIVYTMCLSEIYKTYLDPRIGFLHSTNFRRFSLNLDIAEIFKPIIVDRLIFTLVNRHMLSHKHFEKLTDGILLNEEGRKLFVSELEKKMQTTVQHRHLGKSVSYRRLIRLELYKVQKHLLGEKTYEPYVARW
>NZ_AP022557.1|WP_033022476.1|3262428_3262938_+|CRISPR-associated-protein-Cas4
MEYEMPVTGTDIWYYYICPREVWLMKHQIAPDQEDEAIEIGRFLSETTYQRDKKEISIGSIVIDRIRQEDGQLIIGEVKKSSSYMKSARMQLLYYLDTLRQAGIYAKGELLFPKERKKERVEWTEEGRHELERAIADIRRIVRMPVPPPPKKISFCGKCAYREYCWAEE
>NZ_AP022557.1|WP_033022473.1|3260085_3262419_+|CRISPR-associated-helicase/endonuclease-Cas3
MYSHPHYFLSDHLRGVEQLSSLFLSEKSVRLAESGQLAEVNRWIALFHDIGKSHAFFQRYIQSPDSFQDPPALKSHALLSAVLLAVFLQEKGMDEFWRLLAFLVVKRHHGNLDDWLEELKRMGDEAKTLLKRQAEATDFSALSKQMACLGVGQEAIWTKEVWLAWIERFFAEARSLRRWIMKWNRSNDSLVPYLQLLFLFSLLIDADKSEVGILQKQSWSFSGRKDIPTDLILRYKQQQSWPKTTLNEWRERAFQEVDQAPIDLRHHVYSLNLPTGMGKTLAGLHFALRLRREIERRQRVTPRIIYSLPFLSIIDQTASVLKDVFAASGMQEDHQLWLAHHHLADMRYVTRQDEERYDADYEAAKLLVEGWHSELIVTTFVQLFETIFSHRNASLRKFHRLANSIILIDEVQAVPHRYWLAVRRLFAAMAEELGCYFIFSSATDPKWFPEAVSLVNESAYFQLLSRVTLHPDIDEPVEIEEFARQIEWDEEKTYLFILNTIESAKALYRAFLDEGVDEGDMTFLSTHIPPKERLRRIMAAKNGEYRIVVSTQLIEAGVDIDFDVVYRDFAPLDSIQQAAGRCNRHGQRGGKVHIIRLTDNKKRLYASYIYDAIRLDITQTLLKGKAKIEESEFLQLITAYFETLTARMSNNESERLLKGMMTLYFDGEETVDRLPVSRFRLIEGEGEKFNVFIELDEEASEVFREYEAILRISDRWERRKRFSDIKTRFFQYVIAIPARVDHQPPIVHGIGYVGRDSLSDFYDEALGYRTKSEGLIW
>NZ_AP022557.1|WP_033022467.1|3259340_3260084_+|type-I-B-CRISPR-associated-protein-Cas5
MNVLVFDVRADFGHFRQMYSTSSPLTYSFIPPTALFGLLGAIVGVGKEDNDYLRVFNHETTNVAVRLMEPVRKTRVGINYVNTKGNIWVPKQRREGARTQIRVEFLRFPRFRCYVYMNDHERFSQLVDFVRQHKSVYTPCLGLSECLADVQFVAVDDFHRVEAIDKEPVPICSVIPGRDIQALKVEPGKEYRKERVAWEMDPARVVSRYEEVIFEAGARPLLASVPYYWQNAQGERIVFFYSNGKGE
>NZ_AP022557.1|WP_033022466.1|3258368_3259325_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MVKHRSELLFLYDVQWANPNGDPVDGNKPRIDEETGKNIVTDVRLKRTIRDYLYDYRQQEIFVREIAQDDEYIQDAKARAEDFLVKDGEKLDKSKLTLREMKKIINDEVLRQCIDVRLFGVTLPIEKNQKEKSSITHTGPVQFKMGQSLHRVKMEYIKGTGAFASGGQMTQKTFREEYVLPYSLIAFYGIINEAAARFTGLTEEDVELLMEAMWEGTKNLISRSKVGHVPRLLLRVAYQEPYFHIGELDKYISLHTEKAEEEIRDVSDYVLDVSRLVEVLVQQKEHIANIELRQDGRLACSENLAERLRKEGITVDIR
>NZ_AP022557.1|WP_033022465.1|3256651_3258367_+|TIGR02556-family-CRISPR-associated-protein
MIEAIAQIGKIVLEKQGEGSVVDQLVENPGYPACVLVAVRADEEGNVVWEGCEIEECGSDYKKYLFRSGSSRGTNYSPTAKITTIENTYEQKVIGWFRTVTRKMDHPVLRAIEQLLVQKKEAILQELREKLSLLTDRSLISLKMNGSYLYDCEPFRDAFLHLVHEKDMELSARDQVCAICGERKDTVIGKLSVFRFYTLDKPGFITGGFDEAKAWRNYPVCLSCKAHIEEGRKFVESHLHYRFYGFSYFVIPTLLIPAGKDVLDELLQYLTDGKKDIRVHQEQADSFMTTEEDLLGLMQDYDNSLSLQLLFLQKIQSAERILLLIEDVLPSRISELFQAKKATESLLYREGDHPFHFGFLRTFFRSGVYDKYFLQVVEYVFQKKPLSISFFAPFFMEQLRADFYDYEAGDWSFVNKTRQALAVVLFLEQAGVLVRKGEKAVQGKFAQLFDAYGGQLESPEKQAVFLLGALTQMLLDIQQQKRGSKPFVKQLMGLKMDEKAIKGLLPKVIGKLEEYESYYASHRQLAEEISHLFLSSSPSWKLSVDELNFYFACGMNLSWKVKEIVANKEEK
>NZ_AP022557.1|WP_033022463.1|3251481_3252627_+|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MLFHPKDTRDVMQAASKSMAHLAYHLYYFLEHEWNDKKRVWELSKRLKPAPVLPELKEVGEQLRAQREHALAAWAQTGHVKKLKARLAGRIIHGLGAGHVRETSLTIHPVYGLPYIPASSVKGLVRHWWIEAYGQGEEKSLSEQKNGRDVFGTQEKKGMVQFHDIFLIDGLQLVRDVLAVHMKEYYEGKKAATDDQKPVPVSFWTVTAAEVEIYLTANRSAQNDEEAKRLLEEAAAWTKAALTEWGIGSKTSSGYGRFIDVEDVTETEFLPVVRKETMRLEQRKKEQALLEQRKREEEEQAKLALLSPEERLVAEIVQLTDSQADQQRSKDALYNQVIQQQNKQAAQALLAYWQRIGQWGKSASKKQKEKINVLQQLLNGS
>NZ_AP022557.1|WP_033022462.1|3251058_3251469_+|type-III-B-CRISPR-module-associated-protein-Cmr5
MKKTVQRVGIENGRAAFAFQEVKRAKEQLRENFETYRSYVKKMPSLIQVNGLGQTLAFYFQKKKQNEYKVIYHTLAQWMKEQFPDQFSSGNEELVEVVVHLSSAEYRLWTMEAVALLDWMRKFADGMAKDDGGTAE
>NZ_AP022557.1|WP_033842532.1|3267278_3268187_+|Rpn-family-recombination-promoting-nuclease/putative-transposase
MAIDHDRLFKELIRTFFEEFLLLFFPDMHEHIDFHHLSFLSEELFTDVTAGEKYRVDLLVETKLKGEDGLIIVHVETQGYVQPSFAERMFLYFSRLYESYRTRIVPIAVFHYDSLREEPSVFSMEFPFGEVLQFRFFPVALRKKQWREYIRQDNPVAAALLSQMGYTEREKVELKKEFLRMLVRLELDEARQRLLLGFFETYVKLTEEEEQQLQSEVKAMETKEREKVLELIISYEQKGKKEGLEEGVKRGLAQGMKQGMEQGMKQGMKRLIQTMAQKGMTAAEIAQLVDLSEEEVRSLLSE
>NZ_AP022557.1|WP_033842531.1|3269041_3270178_-|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_156102755.1|3270725_3270893_+|hypothetical-protein
MPMDLFRENAELTQDFHPRVEGKPLPMDLFRENAELTQDFHPRVEGKPLPMDLFP
>NZ_AP022557.1|WP_033842531.1|3271103_3272240_-|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_081897275.1|3272616_3272880_-|CRISPR-associated-endonuclease-Cas2
MRLLVFFDLPVVTNREKREYRRFRTFLLNEGYDMLQFSVYSRVCHGHEATDKHLARLKRNLPPRGSIRAMIVTEKIHGQRDLPSTRG
>NZ_AP022557.1|WP_172418839.1|3272884_3273763_-|type-II-CRISPR-associated-endonuclease-Cas1
MRKPGKLSVRYNQLVIEQEEKVSIPLEDICSIIIEEQAVSVTAVALSKIAEYNIALFTCDQKRLPNGVLQPFQKHSRQVGVLHMQYAYSKPFKKRIWQRIVIQKLVNQGKCLEFLNKEGADELYRISKTVDSGDNNNREAYGAKKYFQYLFGNEFTRRSDSVINAALNYGYAIMRGLVARSLVGYGFFPCLGIYHDNELNKFNLADDFMEVLRPLIDLYVAQHIQPDDEFSPSIRADLYNLVNMDILVNGERLTVVNAVEEMTKSFVTASRSQNPSLLKLPELLPLQLHVYE
>NZ_AP022557.1|WP_033844707.1|3273713_3276977_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MRYKIGLDIGITSVGWAVINLDLPRIEDLGVRIFDRAENPQTGESLALPRRLARSARRRLRRRRHRLERIRRLLTREKVLTQEELDKLFEKKHEIDVWQLRVEALDRKLNNDELARVLLHLAKRRGFKSNRKSERSNKENSTMLKHIEENRSILTGYRTVGEMIVRDPKFVLHKRNKGENYTNTIARDDLEREIQLIFARQRELGNMICTEAFENEYIAIWSSQRPVASKDDIEKKVGFCTFEPKEKRAPKATYTFQSFIAWEHINKLRLVSPSGTRELTDEERRLLYEQAFQKNKLTYHDIRTLLHLPDDTYFKGIVYDWGEPLKQNENIRFLELDAYHQIRKTVDKVYGRGKSSSFLPIDFDTFGYALTLFKDDADIRSYLRNEYEQNGKRIANLANKVYDNELIEELLNLSFTKFGHLSLKALRNILPYMEQGEVYSSACERAGYTFTGPTKKQKTVLLPTIPPIANPVVMRALTQARKVVNAIIKKYGSPVSIHIELARDLSQTFDERKKTKKEQDENRKRNETAIRQLIEYGLTRNPTGHDIVKFKLWSEQNGRCAYSLQPIEIERLLEPGYVEVDHVIPYSRSLDDSYTNKVLVLTKENREKGNRIPAEYLGIGTERWQQFETFVLTNKQFSKKKRDRLLRLHYDESEEAEWKNRNLNDTRYISRFFANFIREHLKFADSDDKQKVYTVNGRVTAHLRSRWDFNKNREESDLHHAVDAAIVACTTPSDIAKVTAFYQRREQAKELAKKTEPHFPQPWPHFADELRARLSKNPKESIKALNLGNYDNEKLESLQPVFVSRMPKRSVTGAAHQETLRRYIGIDERSGKIQTVVKTKLSEIKLDASGHFPMYGKESDPRTYEAIRLRLLEHNNDPRKAFQEPLYKPKKNGEPGPIIRTVKIIDTKNQVIPLNDDKTVAYNSNIVRVDVFEKDRKYYCVPVYTMDIMKKVLPNKAIEPNKPYSEWKEMTEDYTFRFSLYPNDLIRIELPREKTVKTTAGHEINIKDVFVYYKTIDSATGGLELISHDNSFSLRGIGSRTLKRFEKYQVDVLGNIYKVRGEKRVGVASSAHPETGETIRPLQSTRD
>NZ_AP022557.1|WP_033845048.1|3277285_3278341_+|P1-family-peptidase
MRQKLRDLGFSIGTLPTGKRNQITDVSGVRVGHVTVREERDERTVIRTGVTAVLPHGGNWFLEKVPAACFVLNGFGKTAGLVQVEELGTIESPMMLTSTFSVGAVWQGTLEYMMEMTPEIGDTAGSVNIVVGECNDSYLNAARALAVTKAHAKQAIAEARVDMEEGAVGAGTGMMCFGWKGGVGSSSRIAGGMYTVGTLVVSNFGRREELRFVPYVPPSFDERDVPPGSIMMIVATDAPLDARQLKRLAKRAAMGLARTGSHVHHGSGDIVIAFSTAYTIPHVADSVHQALLPLVRDDAPLMNELFQAAVEATEEAIWNSLTMAETTTGRNGRVGEAIPYSLLQRMKWAGE
>NZ_AP022557.1|WP_033844706.1|3278502_3279741_-|MFS-transporter
MDWKRSVRILWLCNFMVSAGMTMVIPFLSLFLWQMGITEHHALSMWTGLVFSATFLSAAIMAPIWGMFADKYGQRANLIRAGIGMGLITACMALTTSPTALLVLRFLVGFFSGFITVSFSYLARVVPKDHSGEALGTLQTGSIAGNIIGPLIGGALSDLFGFRPVFLVTGLCILLTLLPVIFWLEKDPVVPQTKENKASFKDVFEHRPLIILFIATFLVQIAVLGVNSMMTIFVQSLVGHTSNLAFLSGLASSITGIATIIGAPYLGKLGDRIGQEKTLPILLVLSGLFALPQVWTDHIYALYVWRFLQGLVVGGVWPALQALINAQSPRRIQGRVFGVTASSRFLGNLTGPTAAGAIAGLFSIASIFALSGLLLIVTGALVGYAHRRASTPWREGMKEKLAAWTHRLHSRH
>NZ_AP022557.1|WP_033844703.1|3279901_3280555_-|PspA/IM30-family-protein
MGIFRRIKTIVLAEVNEQIDQWEDPIAMTKQYLRELEQQLERGRQALAQQWVAERRYETLIAQAEATVEKRNRQAKLALERNEEAVAKLALRDKLLHEKKREAYKQQYDAIKTKTAEVARRLQELRERYDELAAKQLELTARVNAAQALKQIDTALTSFSADEALRGFARMEERVIALEAEAAAARFGANAALSPVPFEEEVERELAKWKEAQATNA

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Crispr_ID: NZ_AP022557_26

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_26

3268344-3268709

TypeIII

Consensus_repeat	Method
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	PILER-CR
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	CRT

5 spacers

cas6,cas2,cas1,cas4,cas3,cas5,cas7,cas8b1,cmr6gr7,cas9

The CRISPR arrays of NZ_AP022557_26

>merge|NZ_AP022557|26|3268344-3268709|PILER-CR,CRT
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATAATGATGGCTACGACTTTGCGAATGGATCAGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATGAACGCTGGCCGGATTGGGTTGCCAGTGCCGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATAACAGGCTTCTCAGGATGTTGAACGTATCGGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATAAATAACAAAAGAAGAATACGAAAAAGAATGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATGATGATGATTTATACTCCCCCGGCAAGAAAGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT

>NZ_AP022557|26|4|3268344-3268709|PILER-CR
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	AATGATGGCTACGACTTTGCGAATGGATCA
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	GAACGCTGGCCGGATTGGGTTGCCAGTGCC
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	AACAGGCTTCTCAGGATGTTGAACGTATCG
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	AAATAACAAAAGAAGAATACGAAAAAGAAT
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	GATGATGATTTATACTCCCCCGGCAAGAAA
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT

>NZ_AP022557|26|4|3268344-3268709|CRT
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	AATGATGGCTACGACTTTGCGAATGGATCA
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	GAACGCTGGCCGGATTGGGTTGCCAGTGCC
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	AACAGGCTTCTCAGGATGTTGAACGTATCG
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	AAATAACAAAAGAAGAATACGAAAAAGAAT
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT	GATGATGATTTATACTCCCCCGGCAAGAAA
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_081897275.1\|3272616_3272880_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_AP022557.1\|WP_033845048.1\|3277285_3278341_+\|P1-family-peptidase	unknown	unknown	gnl\|CDD\|239071
NZ_AP022557.1\|WP_033842532.1\|3267278_3268187_+\|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl\|CDD\|273806
NZ_AP022557.1\|WP_033844703.1\|3279901_3280555_-\|PspA/IM30-family-protein	unknown	unknown	gnl\|CDD\|224755
NZ_AP022557.1\|WP_033022473.1\|3260085_3262419_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	gnl\|CDD\|187821
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	gnl\|CDD\|213662
NZ_AP022557.1\|WP_033842531.1\|3269041_3270178_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_033022482.1\|3262940_3263942_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NZ_AP022557.1\|WP_172418743.1\|3263953_3264217_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_AP022557.1\|WP_033022467.1\|3259340_3260084_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_AP022557.1\|WP_033022476.1\|3262428_3262938_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_AP022557.1\|WP_033844706.1\|3278502_3279741_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340949
NZ_AP022557.1\|WP_033844702.1\|3280514_3281036_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_156102755.1\|3270725_3270893_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033842531.1\|3271103_3272240_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_033842534.1\|3264387_3265134_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	gnl\|CDD\|378190
NZ_AP022557.1\|WP_033844707.1\|3273713_3276977_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226044
NZ_AP022557.1\|WP_172418839.1\|3272884_3273763_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP022557.1\|WP_081897275.1\|3272616_3272880_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	1.3e-31	103.9	0.0
NZ_AP022557.1\|WP_033022473.1\|3260085_3262419_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	1.9e-55	183.1	0.2
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	3.2e-95	313.4	1.3
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	8.4e-42	138.2	2.5
NZ_AP022557.1\|WP_033844707.1\|3273713_3276977_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	3.6e-215	711.9	20.5
NZ_AP022557.1\|WP_033022467.1\|3259340_3260084_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-39	130.6	0.0
NZ_AP022557.1\|WP_172418743.1\|3263953_3264217_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	1.8e-29	96.7	0.3
NZ_AP022557.1\|WP_033022482.1\|3262940_3263942_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	1.3e-139	459.6	8.2
NZ_AP022557.1\|WP_033022476.1\|3262428_3262938_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	8e-54	176.9	0.1
NZ_AP022557.1\|WP_033842534.1\|3264387_3265134_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	4.2e-41	136.1	0.0
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	2.2e-112	371.4	0.0
NZ_AP022557.1\|WP_172418839.1\|3272884_3273763_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	7.3e-86	282.4	0.1

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_081897275.1\|3272616_3272880_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	4.21797e-30
NZ_AP022557.1\|WP_033845048.1\|3277285_3278341_+\|P1-family-peptidase	gnl\|CDD\|239071	cd02253, DmpA, L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active heterodimeric form. The cleavage results in two polypeptide chains, with one chain containing an N-terminal nucleophile. This group represents one of the rare aminopeptidases that are not metalloenzymes. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	2.4613e-171
NZ_AP022557.1\|WP_033842532.1\|3267278_3268187_+\|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	2.6243e-10
NZ_AP022557.1\|WP_033844703.1\|3279901_3280555_-\|PspA/IM30-family-protein	gnl\|CDD\|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	3.30065e-22
NZ_AP022557.1\|WP_033022473.1\|3260085_3262419_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	5.68476e-45
NZ_AP022557.1\|WP_033022466.1\|3258368_3259325_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl\|CDD\|187821	cd09690, Cas7_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csh2 family.	2.01193e-93
NZ_AP022557.1\|WP_033022463.1\|3251481_3252627_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	8.82685e-42
NZ_AP022557.1\|WP_033842531.1\|3269041_3270178_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_033022482.1\|3262940_3263942_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	6.10823e-172
NZ_AP022557.1\|WP_172418743.1\|3263953_3264217_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	9.67307e-33
NZ_AP022557.1\|WP_033022467.1\|3259340_3260084_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	6.43974e-33
NZ_AP022557.1\|WP_033022476.1\|3262428_3262938_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.21924e-73
NZ_AP022557.1\|WP_033844706.1\|3278502_3279741_-\|MFS-transporter	gnl\|CDD\|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.21794e-110
NZ_AP022557.1\|WP_033842531.1\|3271103_3272240_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_033842534.1\|3264387_3265134_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.04048e-33
NZ_AP022557.1\|WP_033022465.1\|3256651_3258367_+\|TIGR02556-family-CRISPR-associated-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	6.29452e-158
NZ_AP022557.1\|WP_033844707.1\|3273713_3276977_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|226044	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms].	0
NZ_AP022557.1\|WP_172418839.1\|3272884_3273763_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.61295e-95

>NZ_AP022557.1|WP_033842532.1|3267278_3268187_+|Rpn-family-recombination-promoting-nuclease/putative-transposase
MAIDHDRLFKELIRTFFEEFLLLFFPDMHEHIDFHHLSFLSEELFTDVTAGEKYRVDLLVETKLKGEDGLIIVHVETQGYVQPSFAERMFLYFSRLYESYRTRIVPIAVFHYDSLREEPSVFSMEFPFGEVLQFRFFPVALRKKQWREYIRQDNPVAAALLSQMGYTEREKVELKKEFLRMLVRLELDEARQRLLLGFFETYVKLTEEEEQQLQSEVKAMETKEREKVLELIISYEQKGKKEGLEEGVKRGLAQGMKQGMEQGMKQGMKRLIQTMAQKGMTAAEIAQLVDLSEEEVRSLLSE
>NZ_AP022557.1|WP_033842534.1|3264387_3265134_+|CRISPR-associated-endoribonuclease-Cas6
MRLTITMNGRQGPVSLPLHYQHLLQGLLYRSLESERFATFLHEIGFRHGKRSFKLFTFSRLFGKHEVDGGKKTIRFLDDFQWHIDTILPDLTEQLGQQLLLRREIWLYDQPVEVKSVKMDKVEIAQNTIEVAMLSPLTVYSTYETIDGKKKTHFFGPDDDVFPHLVELNFRHKYEAYYGVEPEERLMIEPVHVHHRHRVVTRFKDMYITGWLGHYRLSSSPEQLTFLYHVGLGSRNSQGFGMFRLISE
>NZ_AP022557.1|WP_172418743.1|3263953_3264217_+|CRISPR-associated-endonuclease-Cas2
MFVILVYDFNEKRVAKALKIARKYLHWVQNSVFEGEITTANYEKLKMELRQLMEPDEDSVIFYTFRTQKYSKREEMGVKKGGDEFIL
>NZ_AP022557.1|WP_033022482.1|3262940_3263942_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTLYIFQNGELRRKDNSLYFETEGRKRYIPVENTNDIYIFGEVDVSKRFLEFAAQKEIIVHYFNHYGYYVGSFYPREHLNSGHVIVKQVEHYIDPAKRLELACLFVQGSIRQMERVLKYYRSRLSEPEELEKALQLIEREEGRLNQAETVEQLMAAEGHIREAYYASFDTIIRHPDFVFEKRTKRPPHNRLNALISFGNSIVYTMCLSEIYKTYLDPRIGFLHSTNFRRFSLNLDIAEIFKPIIVDRLIFTLVNRHMLSHKHFEKLTDGILLNEEGRKLFVSELEKKMQTTVQHRHLGKSVSYRRLIRLELYKVQKHLLGEKTYEPYVARW
>NZ_AP022557.1|WP_033022476.1|3262428_3262938_+|CRISPR-associated-protein-Cas4
MEYEMPVTGTDIWYYYICPREVWLMKHQIAPDQEDEAIEIGRFLSETTYQRDKKEISIGSIVIDRIRQEDGQLIIGEVKKSSSYMKSARMQLLYYLDTLRQAGIYAKGELLFPKERKKERVEWTEEGRHELERAIADIRRIVRMPVPPPPKKISFCGKCAYREYCWAEE
>NZ_AP022557.1|WP_033022473.1|3260085_3262419_+|CRISPR-associated-helicase/endonuclease-Cas3
MYSHPHYFLSDHLRGVEQLSSLFLSEKSVRLAESGQLAEVNRWIALFHDIGKSHAFFQRYIQSPDSFQDPPALKSHALLSAVLLAVFLQEKGMDEFWRLLAFLVVKRHHGNLDDWLEELKRMGDEAKTLLKRQAEATDFSALSKQMACLGVGQEAIWTKEVWLAWIERFFAEARSLRRWIMKWNRSNDSLVPYLQLLFLFSLLIDADKSEVGILQKQSWSFSGRKDIPTDLILRYKQQQSWPKTTLNEWRERAFQEVDQAPIDLRHHVYSLNLPTGMGKTLAGLHFALRLRREIERRQRVTPRIIYSLPFLSIIDQTASVLKDVFAASGMQEDHQLWLAHHHLADMRYVTRQDEERYDADYEAAKLLVEGWHSELIVTTFVQLFETIFSHRNASLRKFHRLANSIILIDEVQAVPHRYWLAVRRLFAAMAEELGCYFIFSSATDPKWFPEAVSLVNESAYFQLLSRVTLHPDIDEPVEIEEFARQIEWDEEKTYLFILNTIESAKALYRAFLDEGVDEGDMTFLSTHIPPKERLRRIMAAKNGEYRIVVSTQLIEAGVDIDFDVVYRDFAPLDSIQQAAGRCNRHGQRGGKVHIIRLTDNKKRLYASYIYDAIRLDITQTLLKGKAKIEESEFLQLITAYFETLTARMSNNESERLLKGMMTLYFDGEETVDRLPVSRFRLIEGEGEKFNVFIELDEEASEVFREYEAILRISDRWERRKRFSDIKTRFFQYVIAIPARVDHQPPIVHGIGYVGRDSLSDFYDEALGYRTKSEGLIW
>NZ_AP022557.1|WP_033022467.1|3259340_3260084_+|type-I-B-CRISPR-associated-protein-Cas5
MNVLVFDVRADFGHFRQMYSTSSPLTYSFIPPTALFGLLGAIVGVGKEDNDYLRVFNHETTNVAVRLMEPVRKTRVGINYVNTKGNIWVPKQRREGARTQIRVEFLRFPRFRCYVYMNDHERFSQLVDFVRQHKSVYTPCLGLSECLADVQFVAVDDFHRVEAIDKEPVPICSVIPGRDIQALKVEPGKEYRKERVAWEMDPARVVSRYEEVIFEAGARPLLASVPYYWQNAQGERIVFFYSNGKGE
>NZ_AP022557.1|WP_033022466.1|3258368_3259325_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MVKHRSELLFLYDVQWANPNGDPVDGNKPRIDEETGKNIVTDVRLKRTIRDYLYDYRQQEIFVREIAQDDEYIQDAKARAEDFLVKDGEKLDKSKLTLREMKKIINDEVLRQCIDVRLFGVTLPIEKNQKEKSSITHTGPVQFKMGQSLHRVKMEYIKGTGAFASGGQMTQKTFREEYVLPYSLIAFYGIINEAAARFTGLTEEDVELLMEAMWEGTKNLISRSKVGHVPRLLLRVAYQEPYFHIGELDKYISLHTEKAEEEIRDVSDYVLDVSRLVEVLVQQKEHIANIELRQDGRLACSENLAERLRKEGITVDIR
>NZ_AP022557.1|WP_033022465.1|3256651_3258367_+|TIGR02556-family-CRISPR-associated-protein
MIEAIAQIGKIVLEKQGEGSVVDQLVENPGYPACVLVAVRADEEGNVVWEGCEIEECGSDYKKYLFRSGSSRGTNYSPTAKITTIENTYEQKVIGWFRTVTRKMDHPVLRAIEQLLVQKKEAILQELREKLSLLTDRSLISLKMNGSYLYDCEPFRDAFLHLVHEKDMELSARDQVCAICGERKDTVIGKLSVFRFYTLDKPGFITGGFDEAKAWRNYPVCLSCKAHIEEGRKFVESHLHYRFYGFSYFVIPTLLIPAGKDVLDELLQYLTDGKKDIRVHQEQADSFMTTEEDLLGLMQDYDNSLSLQLLFLQKIQSAERILLLIEDVLPSRISELFQAKKATESLLYREGDHPFHFGFLRTFFRSGVYDKYFLQVVEYVFQKKPLSISFFAPFFMEQLRADFYDYEAGDWSFVNKTRQALAVVLFLEQAGVLVRKGEKAVQGKFAQLFDAYGGQLESPEKQAVFLLGALTQMLLDIQQQKRGSKPFVKQLMGLKMDEKAIKGLLPKVIGKLEEYESYYASHRQLAEEISHLFLSSSPSWKLSVDELNFYFACGMNLSWKVKEIVANKEEK
>NZ_AP022557.1|WP_033022463.1|3251481_3252627_+|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MLFHPKDTRDVMQAASKSMAHLAYHLYYFLEHEWNDKKRVWELSKRLKPAPVLPELKEVGEQLRAQREHALAAWAQTGHVKKLKARLAGRIIHGLGAGHVRETSLTIHPVYGLPYIPASSVKGLVRHWWIEAYGQGEEKSLSEQKNGRDVFGTQEKKGMVQFHDIFLIDGLQLVRDVLAVHMKEYYEGKKAATDDQKPVPVSFWTVTAAEVEIYLTANRSAQNDEEAKRLLEEAAAWTKAALTEWGIGSKTSSGYGRFIDVEDVTETEFLPVVRKETMRLEQRKKEQALLEQRKREEEEQAKLALLSPEERLVAEIVQLTDSQADQQRSKDALYNQVIQQQNKQAAQALLAYWQRIGQWGKSASKKQKEKINVLQQLLNGS
>NZ_AP022557.1|WP_033842531.1|3269041_3270178_-|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_156102755.1|3270725_3270893_+|hypothetical-protein
MPMDLFRENAELTQDFHPRVEGKPLPMDLFRENAELTQDFHPRVEGKPLPMDLFP
>NZ_AP022557.1|WP_033842531.1|3271103_3272240_-|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_081897275.1|3272616_3272880_-|CRISPR-associated-endonuclease-Cas2
MRLLVFFDLPVVTNREKREYRRFRTFLLNEGYDMLQFSVYSRVCHGHEATDKHLARLKRNLPPRGSIRAMIVTEKIHGQRDLPSTRG
>NZ_AP022557.1|WP_172418839.1|3272884_3273763_-|type-II-CRISPR-associated-endonuclease-Cas1
MRKPGKLSVRYNQLVIEQEEKVSIPLEDICSIIIEEQAVSVTAVALSKIAEYNIALFTCDQKRLPNGVLQPFQKHSRQVGVLHMQYAYSKPFKKRIWQRIVIQKLVNQGKCLEFLNKEGADELYRISKTVDSGDNNNREAYGAKKYFQYLFGNEFTRRSDSVINAALNYGYAIMRGLVARSLVGYGFFPCLGIYHDNELNKFNLADDFMEVLRPLIDLYVAQHIQPDDEFSPSIRADLYNLVNMDILVNGERLTVVNAVEEMTKSFVTASRSQNPSLLKLPELLPLQLHVYE
>NZ_AP022557.1|WP_033844707.1|3273713_3276977_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MRYKIGLDIGITSVGWAVINLDLPRIEDLGVRIFDRAENPQTGESLALPRRLARSARRRLRRRRHRLERIRRLLTREKVLTQEELDKLFEKKHEIDVWQLRVEALDRKLNNDELARVLLHLAKRRGFKSNRKSERSNKENSTMLKHIEENRSILTGYRTVGEMIVRDPKFVLHKRNKGENYTNTIARDDLEREIQLIFARQRELGNMICTEAFENEYIAIWSSQRPVASKDDIEKKVGFCTFEPKEKRAPKATYTFQSFIAWEHINKLRLVSPSGTRELTDEERRLLYEQAFQKNKLTYHDIRTLLHLPDDTYFKGIVYDWGEPLKQNENIRFLELDAYHQIRKTVDKVYGRGKSSSFLPIDFDTFGYALTLFKDDADIRSYLRNEYEQNGKRIANLANKVYDNELIEELLNLSFTKFGHLSLKALRNILPYMEQGEVYSSACERAGYTFTGPTKKQKTVLLPTIPPIANPVVMRALTQARKVVNAIIKKYGSPVSIHIELARDLSQTFDERKKTKKEQDENRKRNETAIRQLIEYGLTRNPTGHDIVKFKLWSEQNGRCAYSLQPIEIERLLEPGYVEVDHVIPYSRSLDDSYTNKVLVLTKENREKGNRIPAEYLGIGTERWQQFETFVLTNKQFSKKKRDRLLRLHYDESEEAEWKNRNLNDTRYISRFFANFIREHLKFADSDDKQKVYTVNGRVTAHLRSRWDFNKNREESDLHHAVDAAIVACTTPSDIAKVTAFYQRREQAKELAKKTEPHFPQPWPHFADELRARLSKNPKESIKALNLGNYDNEKLESLQPVFVSRMPKRSVTGAAHQETLRRYIGIDERSGKIQTVVKTKLSEIKLDASGHFPMYGKESDPRTYEAIRLRLLEHNNDPRKAFQEPLYKPKKNGEPGPIIRTVKIIDTKNQVIPLNDDKTVAYNSNIVRVDVFEKDRKYYCVPVYTMDIMKKVLPNKAIEPNKPYSEWKEMTEDYTFRFSLYPNDLIRIELPREKTVKTTAGHEINIKDVFVYYKTIDSATGGLELISHDNSFSLRGIGSRTLKRFEKYQVDVLGNIYKVRGEKRVGVASSAHPETGETIRPLQSTRD
>NZ_AP022557.1|WP_033845048.1|3277285_3278341_+|P1-family-peptidase
MRQKLRDLGFSIGTLPTGKRNQITDVSGVRVGHVTVREERDERTVIRTGVTAVLPHGGNWFLEKVPAACFVLNGFGKTAGLVQVEELGTIESPMMLTSTFSVGAVWQGTLEYMMEMTPEIGDTAGSVNIVVGECNDSYLNAARALAVTKAHAKQAIAEARVDMEEGAVGAGTGMMCFGWKGGVGSSSRIAGGMYTVGTLVVSNFGRREELRFVPYVPPSFDERDVPPGSIMMIVATDAPLDARQLKRLAKRAAMGLARTGSHVHHGSGDIVIAFSTAYTIPHVADSVHQALLPLVRDDAPLMNELFQAAVEATEEAIWNSLTMAETTTGRNGRVGEAIPYSLLQRMKWAGE
>NZ_AP022557.1|WP_033844706.1|3278502_3279741_-|MFS-transporter
MDWKRSVRILWLCNFMVSAGMTMVIPFLSLFLWQMGITEHHALSMWTGLVFSATFLSAAIMAPIWGMFADKYGQRANLIRAGIGMGLITACMALTTSPTALLVLRFLVGFFSGFITVSFSYLARVVPKDHSGEALGTLQTGSIAGNIIGPLIGGALSDLFGFRPVFLVTGLCILLTLLPVIFWLEKDPVVPQTKENKASFKDVFEHRPLIILFIATFLVQIAVLGVNSMMTIFVQSLVGHTSNLAFLSGLASSITGIATIIGAPYLGKLGDRIGQEKTLPILLVLSGLFALPQVWTDHIYALYVWRFLQGLVVGGVWPALQALINAQSPRRIQGRVFGVTASSRFLGNLTGPTAAGAIAGLFSIASIFALSGLLLIVTGALVGYAHRRASTPWREGMKEKLAAWTHRLHSRH
>NZ_AP022557.1|WP_033844703.1|3279901_3280555_-|PspA/IM30-family-protein
MGIFRRIKTIVLAEVNEQIDQWEDPIAMTKQYLRELEQQLERGRQALAQQWVAERRYETLIAQAEATVEKRNRQAKLALERNEEAVAKLALRDKLLHEKKREAYKQQYDAIKTKTAEVARRLQELRERYDELAAKQLELTARVNAAQALKQIDTALTSFSADEALRGFARMEERVIALEAEAAAARFGANAALSPVPFEEEVERELAKWKEAQATNA
>NZ_AP022557.1|WP_033844702.1|3280514_3281036_-|hypothetical-protein
MRKTRAVVWLVLVALVGLSLLHGLTPHEAMAHGGPGVPFDGVHGGVWHHRQALDMGPRASWMLPSLFLWVIPLLLIGVGAVWLTMKRPKRWIGWALVALGVAALLPKWVLIALALVAVYTFGRRQGRKPAAAEAWAPAPPSVSVDWLDQWEKTIQKEAQTNGHFSPDQDDRSR

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Crispr_ID: NZ_AP022557_27

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_27

3352129-3353018

Orphan

Consensus_repeat	Method
GTTTTTATCGTACCTATGAGGGATTGAAAC	PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRT

13 spacers

The CRISPR arrays of NZ_AP022557_27

>merge|NZ_AP022557|27|3352129-3353018|PILER-CR,CRISPRCasFinder,CRT
GTTTTTATCGTACCTATGAGGGATTGAAACCGCACATATTGCTCTCCACCGTTTTCATTGGCGTCCGTTTTTATCGTACCTATGAGGGATTGAAACCTTGAATGGTCATGCTGAAATCATAGCGCGTTGAAGTTTTTATCGTACCTATGAGGGATTGAAACTGATGCCATGGCGATGAAAACCGTATTGAGAAACATGCGTTTTTATCGTACCTATGAGGGATTGAAACCACGCATTTGAGAAAACGAGCATTCAAGCCCGACACAGTTTTTATCGTACCTATGAGGGATTGAAACTCCACACCGCCGATCAATCCGGCAACGGAAGCGTTTTGTTTTTATCGTACCTATGAGGGATTGAAACAACTGTGCTACTCCTCCATCGATACGAAGCCCTGCGTTTTTATCGTACCTATGAGGGATTGAAACGGCTATACCTAACCGAAATTCATCTCCCACTTTCACGTTTTTATCGTACCTATGAGGGATTGAAACTGCCACGGTAAGATGGGGAGAACAAACAGCTGCGGTGTTTTTATCGTACCTATGAGGGATTGAAACCAGCTAGTGACGTTGGAGCAAGTCCGACAGGGCACACGTTTTTATCGTACCTATGAGGGATTGAAACTGCTGTTCGCAGTATCGTCCTTGTGTTAGGTTTGGAGTTTTTATCGTACCTATGAGGGATTGAAACATTTTCCGCTGCCGCTTTCCCCAGCAATCAGCAAATGCGGTTTTTATCGTACCTATGAGGGATTGAAACAAACTCGACCCTTCTAACACAACCTTGCTGGCGCGTTTTTATCGTACCTATGAGGGATTGAAACCGACCTCCTTGGCTGGACAAAGGAGCGGTTCAACGTTTTTATCGTACCTATGAGGGACCTGAAT

>NZ_AP022557|27|5|3352129-3352954|PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGCACATATTGCTCTCCACCGTTTTCATTGGCGTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTTGAATGGTCATGCTGAAATCATAGCGCGTTGAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGATGCCATGGCGATGAAAACCGTATTGAGAAACATGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGCATTTGAGAAAACGAGCATTCAAGCCCGACACA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCACACCGCCGATCAATCCGGCAACGGAAGCGTTTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACTGTGCTACTCCTCCATCGATACGAAGCCCTGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGCTATACCTAACCGAAATTCATCTCCCACTTTCAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCCACGGTAAGATGGGGAGAACAAACAGCTGCGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAGCTAGTGACGTTGGAGCAAGTCCGACAGGGCACAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTGTTCGCAGTATCGTCCTTGTGTTAGGTTTGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTTTCCGCTGCCGCTTTCCCCAGCAATCAGCAAATGCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAACTCGACCCTTCTAACACAACCTTGCTGGCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC

>NZ_AP022557|27|26|3352129-3353018|CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGCACATATTGCTCTCCACCGTTTTCATTGGCGTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTTGAATGGTCATGCTGAAATCATAGCGCGTTGAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGATGCCATGGCGATGAAAACCGTATTGAGAAACATGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGCATTTGAGAAAACGAGCATTCAAGCCCGACACA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCACACCGCCGATCAATCCGGCAACGGAAGCGTTTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACTGTGCTACTCCTCCATCGATACGAAGCCCTGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGCTATACCTAACCGAAATTCATCTCCCACTTTCAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCCACGGTAAGATGGGGAGAACAAACAGCTGCGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAGCTAGTGACGTTGGAGCAAGTCCGACAGGGCACAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTGTTCGCAGTATCGTCCTTGTGTTAGGTTTGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTTTCCGCTGCCGCTTTCCCCAGCAATCAGCAAATGCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAACTCGACCCTTCTAACACAACCTTGCTGGCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGACCTCCTTGGCTGGACAAAGGAGCGGTTCAAC
GTTTTTATCGTACCTATGAGGGACCTGAAT

>NZ_AP022557|27|5|3352129-3353018|CRT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGCACATATTGCTCTCCACCGTTTTCATTGGCGTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTTGAATGGTCATGCTGAAATCATAGCGCGTTGAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGATGCCATGGCGATGAAAACCGTATTGAGAAACATGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGCATTTGAGAAAACGAGCATTCAAGCCCGACACA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCACACCGCCGATCAATCCGGCAACGGAAGCGTTTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACTGTGCTACTCCTCCATCGATACGAAGCCCTGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGCTATACCTAACCGAAATTCATCTCCCACTTTCAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCCACGGTAAGATGGGGAGAACAAACAGCTGCGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAGCTAGTGACGTTGGAGCAAGTCCGACAGGGCACAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCTGTTCGCAGTATCGTCCTTGTGTTAGGTTTGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTTTCCGCTGCCGCTTTCCCCAGCAATCAGCAAATGCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAACTCGACCCTTCTAACACAACCTTGCTGGCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGACCTCCTTGGCTGGACAAAGGAGCGGTTCAAC
GTTTTTATCGTACCTATGAGGGACCTGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033844655.1\|3361545_3361962_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NZ_AP022557.1\|WP_081897270.1\|3339815_3340442_-\|DUF4277-domain-containing-protein	unknown	unknown	gnl\|CDD\|379471
NZ_AP022557.1\|WP_033844653.1\|3363969_3364731_-\|sporulation-protein	unknown	unknown	gnl\|CDD\|369195
NZ_AP022557.1\|WP_033844650.1\|3367609_3368797_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340849
NZ_AP022557.1\|WP_081897269.1\|3342881_3343529_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_AP022557.1\|WP_033844656.1\|3360591_3361467_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187578
NZ_AP022557.1\|WP_081130697.1\|3353219_3354593_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_AP022557.1\|WP_033021375.1\|3338015_3338333_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033844657.1\|3356592_3357978_-\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
NZ_AP022557.1\|WP_033844652.1\|3365112_3366279_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_AP022557.1\|WP_172418745.1\|3339011_3339542_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NZ_AP022557.1\|WP_172418840.1\|3337041_3337491_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NZ_AP022557.1\|WP_033844651.1\|3366569_3367613_+\|NDP-sugar-synthase	unknown	unknown	gnl\|CDD\|224129
NZ_AP022557.1\|WP_061912642.1\|3342426_3342810_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033844662.1\|3337492_3337972_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227947
NZ_AP022557.1\|WP_033844659.1\|3348264_3349554_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_AP022557.1\|WP_172418746.1\|3358650_3360126_+\|alanine:cation-symporter-family-protein	unknown	unknown	gnl\|CDD\|376500
NZ_AP022557.1\|WP_081130697.1\|3340913_3342287_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_AP022557.1\|WP_033844654.1\|3362406_3363789_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NZ_AP022557.1\|WP_051962767.1\|3346726_3348208_+\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|377531

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033844655.1\|3361545_3361962_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	1.1975e-29
NZ_AP022557.1\|WP_081897270.1\|3339815_3340442_-\|DUF4277-domain-containing-protein	gnl\|CDD\|379471	pfam14104, DUF4277, Domain of unknown function (DUF4277). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is approximately 110 amino acids in length. There is a conserved NGLGF sequence motif.	4.57886e-27
NZ_AP022557.1\|WP_033844653.1\|3363969_3364731_-\|sporulation-protein	gnl\|CDD\|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	1.00279e-107
NZ_AP022557.1\|WP_033844650.1\|3367609_3368797_+\|glycosyltransferase	gnl\|CDD\|340849	cd03822, GT4_mannosyltransferase-like, mannosyltransferases of glycosyltransferase family 4 and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.	2.48504e-95
NZ_AP022557.1\|WP_033844651.1\|3366569_3367613_+\|NDP-sugar-synthase	gnl\|CDD\|224129	COG1208, GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis].	3.58823e-105
NZ_AP022557.1\|WP_033844656.1\|3360591_3361467_-\|SDR-family-oxidoreductase	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.9495e-86
NZ_AP022557.1\|WP_033844657.1\|3356592_3357978_-\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
NZ_AP022557.1\|WP_081130697.1\|3353219_3354593_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.25216e-16
NZ_AP022557.1\|WP_033844652.1\|3365112_3366279_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	8.49595e-37
NZ_AP022557.1\|WP_172418745.1\|3339011_3339542_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	4.18004e-20
NZ_AP022557.1\|WP_172418840.1\|3337041_3337491_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	4.17534e-24
NZ_AP022557.1\|WP_033844659.1\|3348264_3349554_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.18895e-44
NZ_AP022557.1\|WP_033844662.1\|3337492_3337972_+\|hypothetical-protein	gnl\|CDD\|227947	COG5660, COG5660, Predicted integral membrane protein [Function unknown].	0.00151055
NZ_AP022557.1\|WP_081897269.1\|3342881_3343529_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	1.54874e-12
NZ_AP022557.1\|WP_172418746.1\|3358650_3360126_+\|alanine:cation-symporter-family-protein	gnl\|CDD\|376500	pfam01235, Na_Ala_symp, Sodium:alanine symporter family.	0
NZ_AP022557.1\|WP_081130697.1\|3340913_3342287_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.25216e-16
NZ_AP022557.1\|WP_033844654.1\|3362406_3363789_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	1.60561e-138
NZ_AP022557.1\|WP_051962767.1\|3346726_3348208_+\|IS5-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.8593e-14

>NZ_AP022557.1|WP_033844659.1|3348264_3349554_+|MFS-transporter
MNFFKDFKIAFFSPGSRPLLIASFLSNIGDWIYFVGMSALLYNTAGALAMTAFIIIRQCMYIVFSPFTGYIADRFPRKSLMLITDLLNGILMFILSFLSIQQINSISLYITLILLVVIFGLINRSARLVVIPKLVEKEFLLSLNALTNIIGTTSLTIAPVIAGLAMKMGGVSWAFLINGISFLLSLLCSLALPSSLNKIEGAKKDMANSYTTKFREITEGLSFVIRVSKARSITFFLITSHLVVGATWVFIPELSKLLQQGDAGIGYLNSAVGAGSILGVFIGAWIGSKRLGTSAIIGVIGLSLSVLLCSISSTYSFSLLIATLVVYGSVTLMGIFANIADAPLWTMIQQVTNDSNAGRVYSAVDALTVGGMALGSFLAGWIISHLSLSFTLVVISIISLIMTGIFIPGIVRSTQKEKSISPSGESYGK
>NZ_AP022557.1|WP_051962767.1|3346726_3348208_+|IS5-family-transposase
MEREQIMKAPKHPSTQPRLFQVIDMEELVPPHHILRQINEAVDFSVIHDGVAPLYTEKTGRPAADPERLLRLMLLSYLFDHSERELYEILPMHAGYLWFCGLDFESVLHPDPHHPTLPDRTTLVKTRKRWRQHGIFDRLMTYVVEQCIAAGLVSPDVHAAADGTQVRANASIHRLREVKLAPVEPLEDYLARTAREDEQDESPETDRDPDDDPPSPSPPSGERVHAGERGNFRGTTFSNQTHRSVTDPDARLYKKGKGQEAYPRYLVHDVIDVQSRVILSRRASLATGTAERETSLEQLASIRFRHPSITIRTLSADKAYGTTEYLKELFVQGITPLVSLRRKEMEEIPTWKRRATDPAQEAQRQANVREVQIRNQARLIQQQGGDRSIQALRTRCEHVFAEGKECHGLDRPRSRGLYAMEEQALLTAVVQNLKRWCRFRKKRGETGSLACAKMEVGAGSPVRPPALWRQMAGRMVPKIRHEGSLCPINSPAF
>NZ_AP022557.1|WP_081897269.1|3342881_3343529_+|VanZ-family-protein
MTVKILKQIGILLACLITSQLIMYYFVDDYIINVASSPIIFISGRLILATVLWIVVNLLFGARKSNFSIKNYRTQFVSFYIIYLVFLVSILFFKDGVYHRQYNFIPLLNLFKYQNVNNDIFIINIISNIFMFIPLGIVALLFIKNKLFNYLQVFLYTSLFIELIQFIFKRGIFDIDDIILNTIGGFIGVYLTQKFLLKKKINLKINYILKTSYYR
>NZ_AP022557.1|WP_061912642.1|3342426_3342810_+|hypothetical-protein
MIKRVAALIGVFSVVFATVAFAASDSYNGYFTTSVMTIGSLDVSDGSISVTHSQEYTLGRTVSIDAYRKGWLGYSKEKTVGKVSSDVTSKSLSTSGFPDGNYKLKFVEISGNCIGCREIHVWGSWKN
>NZ_AP022557.1|WP_081130697.1|3340913_3342287_-|IS1380-family-transposase
MKDFPIRFVLTDEAITPSAGLALVGYLLHRTKLDKRVNALRLPTVRREVHISHSDVIRSMIGLLATGKTDFDHIEAYRQDDIFSASMGIQHVPSSPTLRQRLDQLACLPMTEAIIWEESMRLLVRQHATLSPCWTKGKTTWLPLDVDGSPFDNSDTKKEGVSRTYKGFDGFTPLFAYAGKEGYIVHAELRPGKQHVQDNMPSFLTTAIRRARPLTSSRLLVRMDAGNDAEANVHVCLKEDVDFVIKRNLRRESKALWFQIASQKGRRIDDGQTEGVQTYELCLPQKVAIDGNTYTYVQVTQVTERTMERNGQLMLVPNYEVESYWVRLEGYEHVRMSDVLALYHDHATCEQFHSELKSDLDLERLPSGKMKTNAIVLVMGAFVYNLLRLIGQDLLSDPRHPLHHKVKRRRIKTIIQTVITMAGLLVRRSRQIWMKLTRRSGYSEPLLNVYQKWREAR
>NZ_AP022557.1|WP_081897270.1|3339815_3340442_-|DUF4277-domain-containing-protein
MDVRIRAIYESSYLNIISTLFKDLDLPQLMDHLVPVDPQCQTRASDIVKLIVLDILSGRQALVHLEQWAHDIDLPKLIRPELEPSWFNDDAIARHWDRLYEANLHQVLSSCLVQIDKKEGLSLLALAIYRVFQRRVRQFITPEHPLKGVGGRKLTRPTGQAIFQLFRYVKVVLLELPDGHIQRALGKPLTRDQRRILQGLGMDESIDV
>NZ_AP022557.1|WP_172418745.1|3339011_3339542_-|NUDIX-hydrolase
MIRVQVSCIALLNDKIVMIKKKDKTSAVHGYFIPPGGHVELHETLEQACKREMFEETGLIVDDLELRGVSFIAHTSDYHSVCFWYMTRNVKGKLELKEPEKLTPHLVEIETLYYNKEVTDYHRAFIKEIVEKGNFLNGIVEWCKPDNSIKWSILENTPKNPEYPRYNKEVSIMEKI
>NZ_AP022557.1|WP_033021375.1|3338015_3338333_+|hypothetical-protein
MKNLSMIAGLLGIFVSLAAQLLAINDDDYHFGNIWFIGVLGGIIGTWAAFSININNKKATVLLIISLLLGFAGIGSLYSISAFLQFITLIYLAYKHFHAKGDKHK
>NZ_AP022557.1|WP_033844662.1|3337492_3337972_+|hypothetical-protein
MTDFEKIHVLTKELLVIYNELDEEAKSIVDEHITSCPDCKGLFETYHSTFVFNNQRFCLEQAEQSTEIKPFKKLIQFKTIMYVLLIGIRFLLLSLILNKSFDPTRPALLRGSLIVYYFPFVGLSNIVTFVFYRKSWFWIMLLFDILILLFSADLIYTFF
>NZ_AP022557.1|WP_172418840.1|3337041_3337491_+|RNA-polymerase-sigma-factor
MYLKRFLLKITSDEKLIEDVIQEVFSKMLLNPEKILEVKYIRSWLMVSTRNLLIDHFRKKKPHLLNDEEVITDLLITDLSPEKNLLLKSSIDDILKDLSKADKTLLLAKEYYGYTYEEISVLLNIPISTIKSRIFRLKKRLISRIHRSD
>NZ_AP022557.1|WP_081130697.1|3353219_3354593_-|IS1380-family-transposase
MKDFPIRFVLTDEAITPSAGLALVGYLLHRTKLDKRVNALRLPTVRREVHISHSDVIRSMIGLLATGKTDFDHIEAYRQDDIFSASMGIQHVPSSPTLRQRLDQLACLPMTEAIIWEESMRLLVRQHATLSPCWTKGKTTWLPLDVDGSPFDNSDTKKEGVSRTYKGFDGFTPLFAYAGKEGYIVHAELRPGKQHVQDNMPSFLTTAIRRARPLTSSRLLVRMDAGNDAEANVHVCLKEDVDFVIKRNLRRESKALWFQIASQKGRRIDDGQTEGVQTYELCLPQKVAIDGNTYTYVQVTQVTERTMERNGQLMLVPNYEVESYWVRLEGYEHVRMSDVLALYHDHATCEQFHSELKSDLDLERLPSGKMKTNAIVLVMGAFVYNLLRLIGQDLLSDPRHPLHHKVKRRRIKTIIQTVITMAGLLVRRSRQIWMKLTRRSGYSEPLLNVYQKWREAR
>NZ_AP022557.1|WP_033844657.1|3356592_3357978_-|L-cystine-transporter
MNVYLVIFNIVILLLLIGVLAYMQKKHISFSKRVFTALGLGIVFGFALQLVYGAGSTIIQQSTQWFDIVGTGYVKLLQMIVMPLVFISIVMAFTKLSVTNHLGKIATLIIGLLLGTTAIAASIGIMSALGFQLEAVDIPSGEAEQMRGQELEQKYEQIQTLSFPQKMIELLPANPFLDFTGQRSTSTIAVVIFAAFVGMAYLGVARKQPEQAEMFKKIVDALYAIVMRIVTLVLRLTPYGILAIMSRITATSDVNTIAKLGKFVVASYMALFVMFAVHLIILALAGLNPITYVKKVLPVLSFAFTSRSSAATLPLNIKAQTTALGVPEGVANFAGSFGLSIGQNGCAGIYPAMLAVMIAPTVNIDPTSPSFILTLILVVTISSFGVAGVGGGATFAAILVLSTMNLPVALAGLLISVEPLIDMGRTALNVSGSMTAGIVTSRITKELNVHVYNEETKKLEA
>NZ_AP022557.1|WP_172418746.1|3358650_3360126_+|alanine:cation-symporter-family-protein
MNLIDKLVETVNKLLWSPLLILFIVFCGVYFSIRTRFLQIRHFKEMVKLVTTGKGSDAGVSSFQALTMSLSGRIGVGNVAGTATGIAYGGPGAVFWMWVITFIGAATAYVESTLAQIYKEEQDGQYRGGPAFYIEKGLGWKWFAVVIAAAILLAMAVLMPGIQANSIADGFHNAFRIPQLVTGIIVIALLGFTIFGGVKRIAKTAEIVVPFMAVGYLLVAIAIIAVNFEKIPEVFGLIFKSAFGAEQVFGGIIGSAVMWGVKRGLYANEAGQGTGAHPAAAAEVSHPAKQGLVQAFSIYLDVFLVVTATALMILFTNQYNVINEKTKEPIVVHLEGVEPGAGYTQAAVDTLIPGFGSAFVAIALFFFAFTTMYAYYYIAETNLAYLVRGKHRGIAFLALKIIFLAATFYGTVKTATTAWAMGDTGLGIMVWLNLIAILLLFKPAYLALKDYEEQLKQGKDPEFNASKYGIKNATFWENGYKKAEEKQKEAL
>NZ_AP022557.1|WP_033844656.1|3360591_3361467_-|SDR-family-oxidoreductase
MKLLVTGATGKLGAKVVEALLKSVPANQIAVSVRQPEKAEHLRAQGIDVRCGDFDRPETLNTAFQGIDRLLIISTDGDNETRIRQHTNAVEAAKRAQVGFIAYTSLAKANESRLSLAEVHRVTEEAIIKTGIPYSLLRNNWYLENEIGTIQAVLAGAPWVTSAGAGKVGWALRQDYAEAAAAVLTGSGHENTIYELSGPLLTQEQLAAALGAVLDKEVPVQQADDAAYADIMKNAGLPEPLVSFLVDIQRGIREGSLEVESNDFEKLLGRPVTPINEALTQIVHDIRKTAH
>NZ_AP022557.1|WP_033844655.1|3361545_3361962_-|Rrf2-family-transcriptional-regulator
MKQISTRFSIAVHILCLLAISSTDCTGEFIARSVNTNPVIIRRIVGMLKKAGLVEVRPGVGGASLRKPPDDITLLDVYRAVNATEVDQLFRIHDAPNIECPVGRNIEAVLQAELKEAQFAMEQRLAQTTVGQLVAKFQ
>NZ_AP022557.1|WP_033844654.1|3362406_3363789_+|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MTDRSSFGITIDSLDKKGIGQAAVWHEEDGKRKKMKLAIPSTLPGEKVRVVVDEPKRRRVQGRLEEVIEPHPERLAPPCPHFDRCGGCVWQHWHYEGQLRHKTEHVKALLEQHGFDPNVVRGTIGMEHPWHYRNKMEFTFSPEGLLGLHEHGNFRQVISLETCLIAGEKIVKAAMEVARWARDHRLPGYHKDTHEGLLRHLMVRESFATGEVMVALFATEAPEGDLQEAAADLTERITKALPEVKSLLWLENRAWADRTQAEQTHVLAGRDFIYDELCGFRYRLWFDTFFQTNPVQAAKLVEQALEMGNPQPHEKMIDLFCGVGTFSLPFAKRVKALAGIEIVETSIESAKRNAKDNGIDNTYFLARDARRGIDEVLEQFGRPELLLLDPPRSGAGGKVMRKIGRAQPERVVYVSCNPETLAADMAELVPFGYTLKIVQPVDLFPHTAHVECCALLVKSS
>NZ_AP022557.1|WP_033844653.1|3363969_3364731_-|sporulation-protein
MFKKLLSSIGIGSATVDTKLAKAQYAQGETVEGVVEIRGGSVEQHIDKIDLALVTTYIREVDDHKFEEKAVLARHKVSDSLTIGPNETKTIPFRFTLPYDTPVTLGSSKVWLQTGLDIQMALDPQDRDYLTIEPHPLVTAFLEAARQLGFRLHHVQCEQAPRHWQRRLPFVQEFEFRPASGAFRGRLDELEAIFFVSEHGVETILEIDRKARGFAGLLAEALDMDETLVRFTYGPNDLASLPQLLANAIHRYS
>NZ_AP022557.1|WP_033844652.1|3365112_3366279_-|Gfo/Idh/MocA-family-oxidoreductase
MISSFRYHVGIVGAGAFAEFLAGALASLPSFHLFAVAGRTDAKRQRVIAAYRRRQPQAGDVREYREAEELIVDPHVDIVILTTPPHLHAPLAKRALEEGKHVLLEKPGGLTAEALRANSQLAARQNRALAVNLVLRYHPLSETVKQLIHRALLGAVDYASLHNAAHRVAEGHWFWDERRSGGILIEHGVHFFEVGRDWFGEAAEARGFALTDSDGTRPRVGATIIHEGNGRRLPVHYYHGFTMDPAAPESTHWDVHTTRGRITLDGWIPMQLSVSGLVSTDEAAHMDALLDAIPKQPSSRAIEQIRQAADRLLPSVPRSDAPRIPYERTVVLSDRHGWYEAIAQARFLDFCRLIENPNERGLVTLQDAIADLALAEACTAAETSSSAR
>NZ_AP022557.1|WP_033844651.1|3366569_3367613_+|NDP-sugar-synthase
MKALLLAGGLGTRLRPLTENIPKPMAPIANRPWLEHLIVHLRDQGVNEFVIAAHHCSDVIRRYFEDGKRWNVKITYALEPFPLGTAGAIKNAERWLKERFLVFNADIVHLPQLIPLLDFHRQHGGLATIVLTEVDDPSSYGVVEQNDRGQILRFVEKPRREEAPSNRINAGMYIFEPDVMRYIPAEREVSIERETFPLLIEKNVGVYGIVSNGYWRDMGTPARYRQVHWDALSREFPIPLKGREIQPGVFVGENVEIGAGVLFVPPVLIGDHVKIGPQAVIGPNAVIGDRCQIGARVHCAQTIVWDRSVIRDRSRLQNSIFGYRTVTPAGEVFEDSIINQFKEAVQA
>NZ_AP022557.1|WP_033844650.1|3367609_3368797_+|glycosyltransferase
MIQIAYVSTYPPRRCGLATFTEHLRQSIDGVRGPSDGDRIIVLYNESDGDDAYRHHPMYWPLPAQNRAAYAEMAKRVNESDSDVVLLQHEFGIFGGEAGEYILDFIAALHKPLVTTFHTVFAEPEPPYRPIQEKIATASDAIIVMNRQAIPYLVKAFGLPKEKIVYIPHGAPGPSSEDRDSLRRRLGFSGRKVMLTFGLLSRGKGIESVLAALPGVVRKVPEALYVIAGQTHPEVKKREGEAYREELKSLIHRLGLERHVRMEDRYFSEAELIDYLTACDLYVTPYPGMQQITSGTLAYAVGVGRPVVSTPYEHARDLLQGCEELLLPYGDTTVWEERLGQLLADEAALKRWEEKMRQIGANTHWPRVGEQHVALFARMCAAKRGEVKTVGIVSH

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Crispr_ID: NZ_AP022557_28

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_28

3354673-3356148

Orphan

Consensus_repeat	Method
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRT
GTTTTTATCGTACCTATGAGGGATTGAAAC	PILER-CR

22 spacers

The CRISPR arrays of NZ_AP022557_28

>merge|NZ_AP022557|28|3354673-3356148|CRISPRCasFinder,CRT,PILER-CR
TTTTGTCACGGATTCAGGAGGGATTGAAACTTCCTCCTCAAAACAAAAAAGACGGGATTTCCCGGTTTTTATCGTACCTATGAGGGATTGAAACCACGACATAGACAACCCCGTCTTGTGCGTCCGGCAAGTTTTTATCGTACCTATGAGGGATTGAAACATCAGTTTCATTGCCGATCCCCCTGCCTACTTTTCTGTTTTTATCGTACCTATGAGGGATTGAAACCCTTTTTCATAAATAGAATCCATTAAAGTTTTATCTGTGTTTTTATCGTACCTATGAGGGATTGAAACGACGCTCACGCGGCTGGATTTGAAGAAGTTCAACAAGTTTTTATCGTACCTATGAGGGATTGAAACAACAGATTCAACAAGCGGGCGGCAAAGTGAAAAAAGGGTTTTTATCGTACCTATGAGGGATTGAAACCTGTTACATATTGCACATTACTTCCTACAGATTGCGTTTTTATCGTACCTATGAGGGATTGAAACTTGGAAAACGGGACATTTCTTACGGTGGAACCGGAGTTTTTATCGTACCTATGAGGGATTGAAACCCAACATCGCATCGAACATTGGCGCTTTTCCTGTCGTTTTTATCGTACCTATGAGGGATTGAAACATAACCAAACATCACCTTTTCCTAATTTAAGACCGTTTTTATCGTACCTATGAGGGATTGAAACTGCCTCGATTGCGCGGCCGCATTGGACGCGGAAAAGGGTTTTTATCGTACCTATGAGGGATTGAAACTTGTCCTTCCCTGCCTTTATATCCCTCTCATACTCAGTTTTTATCGTACCTATGAGGGATTGAAACCGCGCTTTTGTCACCATTTTGGTGACTACGGGGTAGTTTTTATCGTACCTATGAGGGATTGAAACGCGGAAGAGTTGTGGGAAGAATATGTCGGATGGGGGTTTTTATCGTACCTATGAGGGATTGAAACTCGTCATCAACAGTACAGCAGAGTGGACAAGCTCGGAGTTTTTATCGTACCTATGAGGGATTGAAACATTGCATACATTTTTCTAGTTTGTCTATATGCTCTGTTTTTATCGTACCTATGAGGGATTGAAACATTCCGAAGAGAACATCGGTTTCTCTTGACACTTATGAGTTTTTATCGTACCTATGAGGGATTGAAACTCTCGCATGTTTGGTCAAAACCCGCGGCCGGCCGAGGTTTTTATCGTACCTATGAGGGATTGAAACTCCCAGCGATAAGGTCAGCTTGTAAGCGGGCTTTTGTTTTTATCGTACCTATGAGGGATTGAAACATAAAACGACGGGTGCAACAGTTGATGCGGGTTCGGTTTTTATCGTACCTATGAGGGATTGAAACTAAATAATAGCCATTTTATATCTCCTTTCTTTTTTGTTTTTATCGTACCTATGAGGGATTGAAACACTTCCAGTATGTCCCCGCAACAAACCGAAGACTTTGTTTTTATCGTACCTATGAAGAATGGAGAT

>NZ_AP022557|28|27|3354673-3356148|CRISPRCasFinder
TTTTGTCACGGATTCAGGAGGGATTGAAAC	TTCCTCCTCAAAACAAAAAAGACGGGATTTCCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGACATAGACAACCCCGTCTTGTGCGTCCGGCAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATCAGTTTCATTGCCGATCCCCCTGCCTACTTTTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCTTTTTCATAAATAGAATCCATTAAAGTTTTATCTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GACGCTCACGCGGCTGGATTTGAAGAAGTTCAACAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACAGATTCAACAAGCGGGCGGCAAAGTGAAAAAAGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTGTTACATATTGCACATTACTTCCTACAGATTGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGGAAAACGGGACATTTCTTACGGTGGAACCGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCAACATCGCATCGAACATTGGCGCTTTTCCTGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAACCAAACATCACCTTTTCCTAATTTAAGACC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCCTCGATTGCGCGGCCGCATTGGACGCGGAAAAGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGTCCTTCCCTGCCTTTATATCCCTCTCATACTCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGCGCTTTTGTCACCATTTTGGTGACTACGGGGTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCGGAAGAGTTGTGGGAAGAATATGTCGGATGGGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCGTCATCAACAGTACAGCAGAGTGGACAAGCTCGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTGCATACATTTTTCTAGTTTGTCTATATGCTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTCCGAAGAGAACATCGGTTTCTCTTGACACTTATGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTCGCATGTTTGGTCAAAACCCGCGGCCGGCCGAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCCAGCGATAAGGTCAGCTTGTAAGCGGGCTTTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAAAACGACGGGTGCAACAGTTGATGCGGGTTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAAATAATAGCCATTTTATATCTCCTTTCTTTTTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACTTCCAGTATGTCCCCGCAACAAACCGAAGACTTT
GTTTTTATCGTACCTATGAAGAATGGAGAT

>NZ_AP022557|28|6|3354673-3356148|CRT
TTTTGTCACGGATTCAGGAGGGATTGAAAC	TTCCTCCTCAAAACAAAAAAGACGGGATTTCCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGACATAGACAACCCCGTCTTGTGCGTCCGGCAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATCAGTTTCATTGCCGATCCCCCTGCCTACTTTTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCTTTTTCATAAATAGAATCCATTAAAGTTTTATCTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GACGCTCACGCGGCTGGATTTGAAGAAGTTCAACAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACAGATTCAACAAGCGGGCGGCAAAGTGAAAAAAGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTGTTACATATTGCACATTACTTCCTACAGATTGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGGAAAACGGGACATTTCTTACGGTGGAACCGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCAACATCGCATCGAACATTGGCGCTTTTCCTGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAACCAAACATCACCTTTTCCTAATTTAAGACC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCCTCGATTGCGCGGCCGCATTGGACGCGGAAAAGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGTCCTTCCCTGCCTTTATATCCCTCTCATACTCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGCGCTTTTGTCACCATTTTGGTGACTACGGGGTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCGGAAGAGTTGTGGGAAGAATATGTCGGATGGGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCGTCATCAACAGTACAGCAGAGTGGACAAGCTCGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTGCATACATTTTTCTAGTTTGTCTATATGCTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTCCGAAGAGAACATCGGTTTCTCTTGACACTTATGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTCGCATGTTTGGTCAAAACCCGCGGCCGGCCGAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCCAGCGATAAGGTCAGCTTGTAAGCGGGCTTTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAAAACGACGGGTGCAACAGTTGATGCGGGTTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAAATAATAGCCATTTTATATCTCCTTTCTTTTTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACTTCCAGTATGTCCCCGCAACAAACCGAAGACTTT
GTTTTTATCGTACCTATGAAGAATGGAGAT

>NZ_AP022557|28|6|3354737-3356082|PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACGACATAGACAACCCCGTCTTGTGCGTCCGGCAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATCAGTTTCATTGCCGATCCCCCTGCCTACTTTTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCTTTTTCATAAATAGAATCCATTAAAGTTTTATCTGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GACGCTCACGCGGCTGGATTTGAAGAAGTTCAACAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACAGATTCAACAAGCGGGCGGCAAAGTGAAAAAAGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTGTTACATATTGCACATTACTTCCTACAGATTGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGGAAAACGGGACATTTCTTACGGTGGAACCGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCAACATCGCATCGAACATTGGCGCTTTTCCTGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAACCAAACATCACCTTTTCCTAATTTAAGACC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCCTCGATTGCGCGGCCGCATTGGACGCGGAAAAGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGTCCTTCCCTGCCTTTATATCCCTCTCATACTCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGCGCTTTTGTCACCATTTTGGTGACTACGGGGTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCGGAAGAGTTGTGGGAAGAATATGTCGGATGGGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCGTCATCAACAGTACAGCAGAGTGGACAAGCTCGGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTGCATACATTTTTCTAGTTTGTCTATATGCTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATTCCGAAGAGAACATCGGTTTCTCTTGACACTTATGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTCGCATGTTTGGTCAAAACCCGCGGCCGGCCGAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCCAGCGATAAGGTCAGCTTGTAAGCGGGCTTTT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ATAAAACGACGGGTGCAACAGTTGATGCGGGTTCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAAATAATAGCCATTTTATATCTCCTTTCTTTTTT
GTTTTTATCGTACCTATGAGGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_033844647.1\|3368777_3369893_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033844655.1\|3361545_3361962_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NZ_AP022557.1\|WP_081897270.1\|3339815_3340442_-\|DUF4277-domain-containing-protein	unknown	unknown	gnl\|CDD\|379471
NZ_AP022557.1\|WP_033844653.1\|3363969_3364731_-\|sporulation-protein	unknown	unknown	gnl\|CDD\|369195
NZ_AP022557.1\|WP_033844650.1\|3367609_3368797_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340849
NZ_AP022557.1\|WP_081897269.1\|3342881_3343529_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_AP022557.1\|WP_033844656.1\|3360591_3361467_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187578
NZ_AP022557.1\|WP_033844657.1\|3356592_3357978_-\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
NZ_AP022557.1\|WP_081130697.1\|3353219_3354593_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_AP022557.1\|WP_033021375.1\|3338015_3338333_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033844651.1\|3366569_3367613_+\|NDP-sugar-synthase	unknown	unknown	gnl\|CDD\|224129
NZ_AP022557.1\|WP_033844652.1\|3365112_3366279_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_AP022557.1\|WP_172418745.1\|3339011_3339542_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NZ_AP022557.1\|WP_051962767.1\|3346726_3348208_+\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|377531
NZ_AP022557.1\|WP_061912642.1\|3342426_3342810_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033844659.1\|3348264_3349554_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_AP022557.1\|WP_172418746.1\|3358650_3360126_+\|alanine:cation-symporter-family-protein	unknown	unknown	gnl\|CDD\|376500
NZ_AP022557.1\|WP_081130697.1\|3340913_3342287_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_AP022557.1\|WP_033844654.1\|3362406_3363789_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NZ_AP022557.1\|WP_033844662.1\|3337492_3337972_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227947

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_033844655.1\|3361545_3361962_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	1.1975e-29
NZ_AP022557.1\|WP_081897270.1\|3339815_3340442_-\|DUF4277-domain-containing-protein	gnl\|CDD\|379471	pfam14104, DUF4277, Domain of unknown function (DUF4277). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is approximately 110 amino acids in length. There is a conserved NGLGF sequence motif.	4.57886e-27
NZ_AP022557.1\|WP_033844653.1\|3363969_3364731_-\|sporulation-protein	gnl\|CDD\|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	1.00279e-107
NZ_AP022557.1\|WP_033844650.1\|3367609_3368797_+\|glycosyltransferase	gnl\|CDD\|340849	cd03822, GT4_mannosyltransferase-like, mannosyltransferases of glycosyltransferase family 4 and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.	2.48504e-95
NZ_AP022557.1\|WP_033844651.1\|3366569_3367613_+\|NDP-sugar-synthase	gnl\|CDD\|224129	COG1208, GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis].	3.58823e-105
NZ_AP022557.1\|WP_033844657.1\|3356592_3357978_-\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
NZ_AP022557.1\|WP_081130697.1\|3353219_3354593_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.25216e-16
NZ_AP022557.1\|WP_033844652.1\|3365112_3366279_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	8.49595e-37
NZ_AP022557.1\|WP_172418745.1\|3339011_3339542_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	4.18004e-20
NZ_AP022557.1\|WP_051962767.1\|3346726_3348208_+\|IS5-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.8593e-14
NZ_AP022557.1\|WP_033844659.1\|3348264_3349554_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.18895e-44
NZ_AP022557.1\|WP_033844662.1\|3337492_3337972_+\|hypothetical-protein	gnl\|CDD\|227947	COG5660, COG5660, Predicted integral membrane protein [Function unknown].	0.00151055
NZ_AP022557.1\|WP_081897269.1\|3342881_3343529_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	1.54874e-12
NZ_AP022557.1\|WP_172418746.1\|3358650_3360126_+\|alanine:cation-symporter-family-protein	gnl\|CDD\|376500	pfam01235, Na_Ala_symp, Sodium:alanine symporter family.	0
NZ_AP022557.1\|WP_081130697.1\|3340913_3342287_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.25216e-16
NZ_AP022557.1\|WP_033844654.1\|3362406_3363789_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	1.60561e-138
NZ_AP022557.1\|WP_033844656.1\|3360591_3361467_-\|SDR-family-oxidoreductase	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.9495e-86

>NZ_AP022557.1|WP_081130697.1|3353219_3354593_-|IS1380-family-transposase
MKDFPIRFVLTDEAITPSAGLALVGYLLHRTKLDKRVNALRLPTVRREVHISHSDVIRSMIGLLATGKTDFDHIEAYRQDDIFSASMGIQHVPSSPTLRQRLDQLACLPMTEAIIWEESMRLLVRQHATLSPCWTKGKTTWLPLDVDGSPFDNSDTKKEGVSRTYKGFDGFTPLFAYAGKEGYIVHAELRPGKQHVQDNMPSFLTTAIRRARPLTSSRLLVRMDAGNDAEANVHVCLKEDVDFVIKRNLRRESKALWFQIASQKGRRIDDGQTEGVQTYELCLPQKVAIDGNTYTYVQVTQVTERTMERNGQLMLVPNYEVESYWVRLEGYEHVRMSDVLALYHDHATCEQFHSELKSDLDLERLPSGKMKTNAIVLVMGAFVYNLLRLIGQDLLSDPRHPLHHKVKRRRIKTIIQTVITMAGLLVRRSRQIWMKLTRRSGYSEPLLNVYQKWREAR
>NZ_AP022557.1|WP_033844659.1|3348264_3349554_+|MFS-transporter
MNFFKDFKIAFFSPGSRPLLIASFLSNIGDWIYFVGMSALLYNTAGALAMTAFIIIRQCMYIVFSPFTGYIADRFPRKSLMLITDLLNGILMFILSFLSIQQINSISLYITLILLVVIFGLINRSARLVVIPKLVEKEFLLSLNALTNIIGTTSLTIAPVIAGLAMKMGGVSWAFLINGISFLLSLLCSLALPSSLNKIEGAKKDMANSYTTKFREITEGLSFVIRVSKARSITFFLITSHLVVGATWVFIPELSKLLQQGDAGIGYLNSAVGAGSILGVFIGAWIGSKRLGTSAIIGVIGLSLSVLLCSISSTYSFSLLIATLVVYGSVTLMGIFANIADAPLWTMIQQVTNDSNAGRVYSAVDALTVGGMALGSFLAGWIISHLSLSFTLVVISIISLIMTGIFIPGIVRSTQKEKSISPSGESYGK
>NZ_AP022557.1|WP_051962767.1|3346726_3348208_+|IS5-family-transposase
MEREQIMKAPKHPSTQPRLFQVIDMEELVPPHHILRQINEAVDFSVIHDGVAPLYTEKTGRPAADPERLLRLMLLSYLFDHSERELYEILPMHAGYLWFCGLDFESVLHPDPHHPTLPDRTTLVKTRKRWRQHGIFDRLMTYVVEQCIAAGLVSPDVHAAADGTQVRANASIHRLREVKLAPVEPLEDYLARTAREDEQDESPETDRDPDDDPPSPSPPSGERVHAGERGNFRGTTFSNQTHRSVTDPDARLYKKGKGQEAYPRYLVHDVIDVQSRVILSRRASLATGTAERETSLEQLASIRFRHPSITIRTLSADKAYGTTEYLKELFVQGITPLVSLRRKEMEEIPTWKRRATDPAQEAQRQANVREVQIRNQARLIQQQGGDRSIQALRTRCEHVFAEGKECHGLDRPRSRGLYAMEEQALLTAVVQNLKRWCRFRKKRGETGSLACAKMEVGAGSPVRPPALWRQMAGRMVPKIRHEGSLCPINSPAF
>NZ_AP022557.1|WP_081897269.1|3342881_3343529_+|VanZ-family-protein
MTVKILKQIGILLACLITSQLIMYYFVDDYIINVASSPIIFISGRLILATVLWIVVNLLFGARKSNFSIKNYRTQFVSFYIIYLVFLVSILFFKDGVYHRQYNFIPLLNLFKYQNVNNDIFIINIISNIFMFIPLGIVALLFIKNKLFNYLQVFLYTSLFIELIQFIFKRGIFDIDDIILNTIGGFIGVYLTQKFLLKKKINLKINYILKTSYYR
>NZ_AP022557.1|WP_061912642.1|3342426_3342810_+|hypothetical-protein
MIKRVAALIGVFSVVFATVAFAASDSYNGYFTTSVMTIGSLDVSDGSISVTHSQEYTLGRTVSIDAYRKGWLGYSKEKTVGKVSSDVTSKSLSTSGFPDGNYKLKFVEISGNCIGCREIHVWGSWKN
>NZ_AP022557.1|WP_081130697.1|3340913_3342287_-|IS1380-family-transposase
MKDFPIRFVLTDEAITPSAGLALVGYLLHRTKLDKRVNALRLPTVRREVHISHSDVIRSMIGLLATGKTDFDHIEAYRQDDIFSASMGIQHVPSSPTLRQRLDQLACLPMTEAIIWEESMRLLVRQHATLSPCWTKGKTTWLPLDVDGSPFDNSDTKKEGVSRTYKGFDGFTPLFAYAGKEGYIVHAELRPGKQHVQDNMPSFLTTAIRRARPLTSSRLLVRMDAGNDAEANVHVCLKEDVDFVIKRNLRRESKALWFQIASQKGRRIDDGQTEGVQTYELCLPQKVAIDGNTYTYVQVTQVTERTMERNGQLMLVPNYEVESYWVRLEGYEHVRMSDVLALYHDHATCEQFHSELKSDLDLERLPSGKMKTNAIVLVMGAFVYNLLRLIGQDLLSDPRHPLHHKVKRRRIKTIIQTVITMAGLLVRRSRQIWMKLTRRSGYSEPLLNVYQKWREAR
>NZ_AP022557.1|WP_081897270.1|3339815_3340442_-|DUF4277-domain-containing-protein
MDVRIRAIYESSYLNIISTLFKDLDLPQLMDHLVPVDPQCQTRASDIVKLIVLDILSGRQALVHLEQWAHDIDLPKLIRPELEPSWFNDDAIARHWDRLYEANLHQVLSSCLVQIDKKEGLSLLALAIYRVFQRRVRQFITPEHPLKGVGGRKLTRPTGQAIFQLFRYVKVVLLELPDGHIQRALGKPLTRDQRRILQGLGMDESIDV
>NZ_AP022557.1|WP_172418745.1|3339011_3339542_-|NUDIX-hydrolase
MIRVQVSCIALLNDKIVMIKKKDKTSAVHGYFIPPGGHVELHETLEQACKREMFEETGLIVDDLELRGVSFIAHTSDYHSVCFWYMTRNVKGKLELKEPEKLTPHLVEIETLYYNKEVTDYHRAFIKEIVEKGNFLNGIVEWCKPDNSIKWSILENTPKNPEYPRYNKEVSIMEKI
>NZ_AP022557.1|WP_033021375.1|3338015_3338333_+|hypothetical-protein
MKNLSMIAGLLGIFVSLAAQLLAINDDDYHFGNIWFIGVLGGIIGTWAAFSININNKKATVLLIISLLLGFAGIGSLYSISAFLQFITLIYLAYKHFHAKGDKHK
>NZ_AP022557.1|WP_033844662.1|3337492_3337972_+|hypothetical-protein
MTDFEKIHVLTKELLVIYNELDEEAKSIVDEHITSCPDCKGLFETYHSTFVFNNQRFCLEQAEQSTEIKPFKKLIQFKTIMYVLLIGIRFLLLSLILNKSFDPTRPALLRGSLIVYYFPFVGLSNIVTFVFYRKSWFWIMLLFDILILLFSADLIYTFF
>NZ_AP022557.1|WP_033844657.1|3356592_3357978_-|L-cystine-transporter
MNVYLVIFNIVILLLLIGVLAYMQKKHISFSKRVFTALGLGIVFGFALQLVYGAGSTIIQQSTQWFDIVGTGYVKLLQMIVMPLVFISIVMAFTKLSVTNHLGKIATLIIGLLLGTTAIAASIGIMSALGFQLEAVDIPSGEAEQMRGQELEQKYEQIQTLSFPQKMIELLPANPFLDFTGQRSTSTIAVVIFAAFVGMAYLGVARKQPEQAEMFKKIVDALYAIVMRIVTLVLRLTPYGILAIMSRITATSDVNTIAKLGKFVVASYMALFVMFAVHLIILALAGLNPITYVKKVLPVLSFAFTSRSSAATLPLNIKAQTTALGVPEGVANFAGSFGLSIGQNGCAGIYPAMLAVMIAPTVNIDPTSPSFILTLILVVTISSFGVAGVGGGATFAAILVLSTMNLPVALAGLLISVEPLIDMGRTALNVSGSMTAGIVTSRITKELNVHVYNEETKKLEA
>NZ_AP022557.1|WP_172418746.1|3358650_3360126_+|alanine:cation-symporter-family-protein
MNLIDKLVETVNKLLWSPLLILFIVFCGVYFSIRTRFLQIRHFKEMVKLVTTGKGSDAGVSSFQALTMSLSGRIGVGNVAGTATGIAYGGPGAVFWMWVITFIGAATAYVESTLAQIYKEEQDGQYRGGPAFYIEKGLGWKWFAVVIAAAILLAMAVLMPGIQANSIADGFHNAFRIPQLVTGIIVIALLGFTIFGGVKRIAKTAEIVVPFMAVGYLLVAIAIIAVNFEKIPEVFGLIFKSAFGAEQVFGGIIGSAVMWGVKRGLYANEAGQGTGAHPAAAAEVSHPAKQGLVQAFSIYLDVFLVVTATALMILFTNQYNVINEKTKEPIVVHLEGVEPGAGYTQAAVDTLIPGFGSAFVAIALFFFAFTTMYAYYYIAETNLAYLVRGKHRGIAFLALKIIFLAATFYGTVKTATTAWAMGDTGLGIMVWLNLIAILLLFKPAYLALKDYEEQLKQGKDPEFNASKYGIKNATFWENGYKKAEEKQKEAL
>NZ_AP022557.1|WP_033844656.1|3360591_3361467_-|SDR-family-oxidoreductase
MKLLVTGATGKLGAKVVEALLKSVPANQIAVSVRQPEKAEHLRAQGIDVRCGDFDRPETLNTAFQGIDRLLIISTDGDNETRIRQHTNAVEAAKRAQVGFIAYTSLAKANESRLSLAEVHRVTEEAIIKTGIPYSLLRNNWYLENEIGTIQAVLAGAPWVTSAGAGKVGWALRQDYAEAAAAVLTGSGHENTIYELSGPLLTQEQLAAALGAVLDKEVPVQQADDAAYADIMKNAGLPEPLVSFLVDIQRGIREGSLEVESNDFEKLLGRPVTPINEALTQIVHDIRKTAH
>NZ_AP022557.1|WP_033844655.1|3361545_3361962_-|Rrf2-family-transcriptional-regulator
MKQISTRFSIAVHILCLLAISSTDCTGEFIARSVNTNPVIIRRIVGMLKKAGLVEVRPGVGGASLRKPPDDITLLDVYRAVNATEVDQLFRIHDAPNIECPVGRNIEAVLQAELKEAQFAMEQRLAQTTVGQLVAKFQ
>NZ_AP022557.1|WP_033844654.1|3362406_3363789_+|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MTDRSSFGITIDSLDKKGIGQAAVWHEEDGKRKKMKLAIPSTLPGEKVRVVVDEPKRRRVQGRLEEVIEPHPERLAPPCPHFDRCGGCVWQHWHYEGQLRHKTEHVKALLEQHGFDPNVVRGTIGMEHPWHYRNKMEFTFSPEGLLGLHEHGNFRQVISLETCLIAGEKIVKAAMEVARWARDHRLPGYHKDTHEGLLRHLMVRESFATGEVMVALFATEAPEGDLQEAAADLTERITKALPEVKSLLWLENRAWADRTQAEQTHVLAGRDFIYDELCGFRYRLWFDTFFQTNPVQAAKLVEQALEMGNPQPHEKMIDLFCGVGTFSLPFAKRVKALAGIEIVETSIESAKRNAKDNGIDNTYFLARDARRGIDEVLEQFGRPELLLLDPPRSGAGGKVMRKIGRAQPERVVYVSCNPETLAADMAELVPFGYTLKIVQPVDLFPHTAHVECCALLVKSS
>NZ_AP022557.1|WP_033844653.1|3363969_3364731_-|sporulation-protein
MFKKLLSSIGIGSATVDTKLAKAQYAQGETVEGVVEIRGGSVEQHIDKIDLALVTTYIREVDDHKFEEKAVLARHKVSDSLTIGPNETKTIPFRFTLPYDTPVTLGSSKVWLQTGLDIQMALDPQDRDYLTIEPHPLVTAFLEAARQLGFRLHHVQCEQAPRHWQRRLPFVQEFEFRPASGAFRGRLDELEAIFFVSEHGVETILEIDRKARGFAGLLAEALDMDETLVRFTYGPNDLASLPQLLANAIHRYS
>NZ_AP022557.1|WP_033844652.1|3365112_3366279_-|Gfo/Idh/MocA-family-oxidoreductase
MISSFRYHVGIVGAGAFAEFLAGALASLPSFHLFAVAGRTDAKRQRVIAAYRRRQPQAGDVREYREAEELIVDPHVDIVILTTPPHLHAPLAKRALEEGKHVLLEKPGGLTAEALRANSQLAARQNRALAVNLVLRYHPLSETVKQLIHRALLGAVDYASLHNAAHRVAEGHWFWDERRSGGILIEHGVHFFEVGRDWFGEAAEARGFALTDSDGTRPRVGATIIHEGNGRRLPVHYYHGFTMDPAAPESTHWDVHTTRGRITLDGWIPMQLSVSGLVSTDEAAHMDALLDAIPKQPSSRAIEQIRQAADRLLPSVPRSDAPRIPYERTVVLSDRHGWYEAIAQARFLDFCRLIENPNERGLVTLQDAIADLALAEACTAAETSSSAR
>NZ_AP022557.1|WP_033844651.1|3366569_3367613_+|NDP-sugar-synthase
MKALLLAGGLGTRLRPLTENIPKPMAPIANRPWLEHLIVHLRDQGVNEFVIAAHHCSDVIRRYFEDGKRWNVKITYALEPFPLGTAGAIKNAERWLKERFLVFNADIVHLPQLIPLLDFHRQHGGLATIVLTEVDDPSSYGVVEQNDRGQILRFVEKPRREEAPSNRINAGMYIFEPDVMRYIPAEREVSIERETFPLLIEKNVGVYGIVSNGYWRDMGTPARYRQVHWDALSREFPIPLKGREIQPGVFVGENVEIGAGVLFVPPVLIGDHVKIGPQAVIGPNAVIGDRCQIGARVHCAQTIVWDRSVIRDRSRLQNSIFGYRTVTPAGEVFEDSIINQFKEAVQA
>NZ_AP022557.1|WP_033844650.1|3367609_3368797_+|glycosyltransferase
MIQIAYVSTYPPRRCGLATFTEHLRQSIDGVRGPSDGDRIIVLYNESDGDDAYRHHPMYWPLPAQNRAAYAEMAKRVNESDSDVVLLQHEFGIFGGEAGEYILDFIAALHKPLVTTFHTVFAEPEPPYRPIQEKIATASDAIIVMNRQAIPYLVKAFGLPKEKIVYIPHGAPGPSSEDRDSLRRRLGFSGRKVMLTFGLLSRGKGIESVLAALPGVVRKVPEALYVIAGQTHPEVKKREGEAYREELKSLIHRLGLERHVRMEDRYFSEAELIDYLTACDLYVTPYPGMQQITSGTLAYAVGVGRPVVSTPYEHARDLLQGCEELLLPYGDTTVWEERLGQLLADEAALKRWEEKMRQIGANTHWPRVGEQHVALFARMCAAKRGEVKTVGIVSH
>NZ_AP022557.1|WP_033844647.1|3368777_3369893_+|hypothetical-protein
MASSVIKFDHLERMTDDTGLLEHSLGRIPRRREGYSTDDNARAIWVCLEWLALCQDTKTNERLYRLLDRYLAFLLWAQNEDGTFHNNFFFDRTKEEETPSDDCFGRSFWAAAMAYVRLRDPARREAAAEMLRRAIPAAWELRSLRGSAWGLAACGVLLTEGRPPGVDEQEAAALAARFEERLLSAYASNADARWRWYESELTYANGVLPWALWTAYRRAPRHEVREVAEKSLAFLIDNMSGPGGVIRPIGNRGWCNRRYRADWDQQPLDVMKLALAAREAYWATDDEQYRSVVCRCLAWFYGENDGKAPLADPSDGSCCDGLGPNGPNPNRGAESTLSYLLTAAIAQSISVEVAVDELVHYKTVRMAGARV

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Crispr_ID: NZ_AP022557_29

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_29

3399976-3400069

Orphan

Consensus_repeat	Method
GTTTAAAAAAAACAAAGACAACATGCAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_29

>merge|NZ_AP022557|29|3399976-3400069|CRISPRCasFinder
GTTTAAAAAAAACAAAGACAACATGCAACGATGGCGGGACGGACAATACGACATTTCCATCATCGGTTTAAAAAAATCAAAGACAACATGCAAC

>NZ_AP022557|29|28|3399976-3400069|CRISPRCasFinder
GTTTAAAAAAAACAAAGACAACATGCAAC	GATGGCGGGACGGACAATACGACATTTCCATCATCG
GTTTAAAAAAATCAAAGACAACATGCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_172418750.1\|3395951_3396980_-\|XdhC-family-protein	unknown	unknown	gnl\|CDD\|224886
NZ_AP022557.1\|WP_172418756.1\|3409084_3410515_-\|iron-sulfur-cluster-binding-protein	unknown	unknown	gnl\|CDD\|224062
NZ_AP022557.1\|WP_172418748.1\|3393002_3395330_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl\|CDD\|224446
NZ_AP022557.1\|WP_172418755.1\|3402393_3403326_+\|D-2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240625
NZ_AP022557.1\|WP_153017136.1\|3407345_3407558_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418751.1\|3397170_3397347_-\|Arc-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|227214
NZ_AP022557.1\|WP_033844628.1\|3391409_3391892_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NZ_AP022557.1\|WP_033844632.1\|3387706_3388861_+\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224662
NZ_AP022557.1\|WP_172418749.1\|3395301_3395955_-\|xanthine-dehydrogenase-accessory-protein-PucB	unknown	unknown	gnl\|CDD\|132246
NZ_AP022557.1\|WP_061912375.1\|3401683_3402370_+\|TerC-family-protein	unknown	unknown	gnl\|CDD\|163429
NZ_AP022557.1\|WP_061912372.1\|3408365_3409088_-\|lactate-utilization-protein-C	unknown	unknown	gnl\|CDD\|224473
NZ_AP022557.1\|WP_033844630.1\|3390111_3390537_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133383
NZ_AP022557.1\|WP_033844631.1\|3388954_3390112_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NZ_AP022557.1\|WP_082799322.1\|3412138_3412738_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_AP022557.1\|WP_172418752.1\|3397887_3398337_+\|hut-operon-transcriptional-regulator-HutP	unknown	unknown	gnl\|CDD\|179531
NZ_AP022557.1\|WP_061912374.1\|3404456_3405002_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912607.1\|3412709_3414797_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_AP022557.1\|WP_082799321.1\|3410453_3411251_-\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NZ_AP022557.1\|WP_033844627.1\|3392179_3393016_-\|FAD-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224238
NZ_AP022557.1\|WP_172418754.1\|3400142_3401405_+\|glycoside-hydrolase-family-18-protein	unknown	unknown	gnl\|CDD\|226376

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_172418750.1\|3395951_3396980_-\|XdhC-family-protein	gnl\|CDD\|224886	COG1975, XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones].	2.66832e-42
NZ_AP022557.1\|WP_172418756.1\|3409084_3410515_-\|iron-sulfur-cluster-binding-protein	gnl\|CDD\|224062	COG1139, COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion].	0
NZ_AP022557.1\|WP_172418748.1\|3393002_3395330_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	0
NZ_AP022557.1\|WP_172418755.1\|3402393_3403326_+\|D-2-hydroxyacid-dehydrogenase	gnl\|CDD\|240625	cd05300, 2-Hacid_dh_1, Putative D-isomer specific 2-hydroxyacid dehydrogenase. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomains but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric. Formate dehydrogenase (FDH) catalyzes the NAD+-dependent oxidation of formate ion to carbon dioxide with the concomitant reduction of NAD+ to NADH. FDHs of this family contain no metal ions or prosthetic groups. Catalysis occurs though direct transfer of the hydride ion to NAD+ without the stages of acid-base catalysis typically found in related dehydrogenases. FDHs are found in all methylotrophic microorganisms in energy production and in the stress responses of plants.	2.15121e-116
NZ_AP022557.1\|WP_172418751.1\|3397170_3397347_-\|Arc-family-DNA-binding-protein	gnl\|CDD\|227214	COG4877, COG4877, Uncharacterized protein conserved in bacteria [Function unknown].	4.83024e-14
NZ_AP022557.1\|WP_033844628.1\|3391409_3391892_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	2.59128e-64
NZ_AP022557.1\|WP_033844632.1\|3387706_3388861_+\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	gnl\|CDD\|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	2.34773e-86
NZ_AP022557.1\|WP_172418749.1\|3395301_3395955_-\|xanthine-dehydrogenase-accessory-protein-PucB	gnl\|CDD\|132246	TIGR03202, pucB, xanthine dehydrogenase accessory protein pucB. In Bacillus subtilis the expression of this protein, located in an operon with the structural subunits of xanthine dehydrogenase, has been found to be essential for XDH activity. Some members of this family appear to have a distant relationship to the MobA protein involved in molybdopterin biosynthesis, although this may be coincidental.	5.17112e-84
NZ_AP022557.1\|WP_061912375.1\|3401683_3402370_+\|TerC-family-protein	gnl\|CDD\|163429	TIGR03717, R_switched_YjbE, integral membrane protein, YjbE family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family commonly are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains protein YjbE from Bacillus subtilis. A transport function is proposed.	1.544e-76
NZ_AP022557.1\|WP_033844630.1\|3390111_3390537_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133383	cd01108, HTH_CueR, Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators. Helix-turn-helix (HTH) transcription regulators CueR and ActP, copper efflux regulators. In Bacillus subtilis, copper induced CueR regulates the copZA operon, preventing copper toxicity. In Rhizobium leguminosarum, ActP controls copper homeostasis; it detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. These proteins are comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain winged HTH motifs that mediate DNA binding, while the C-terminal domains have two conserved cysteines that define a monovalent copper ion binding site. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	6.19876e-26
NZ_AP022557.1\|WP_033844631.1\|3388954_3390112_-\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.22386e-97
NZ_AP022557.1\|WP_082799322.1\|3412138_3412738_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.19451e-55
NZ_AP022557.1\|WP_172418752.1\|3397887_3398337_+\|hut-operon-transcriptional-regulator-HutP	gnl\|CDD\|179531	PRK03065, hutP, anti-terminator HutP; Provisional.	6.28662e-91
NZ_AP022557.1\|WP_061912372.1\|3408365_3409088_-\|lactate-utilization-protein-C	gnl\|CDD\|224473	COG1556, COG1556, Uncharacterized conserved protein [Function unknown].	1.43656e-82
NZ_AP022557.1\|WP_061912607.1\|3412709_3414797_-\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.63853e-29
NZ_AP022557.1\|WP_082799321.1\|3410453_3411251_-\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	2.05194e-63
NZ_AP022557.1\|WP_033844627.1\|3392179_3393016_-\|FAD-binding-domain-containing-protein	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	7.20751e-48
NZ_AP022557.1\|WP_172418754.1\|3400142_3401405_+\|glycoside-hydrolase-family-18-protein	gnl\|CDD\|226376	COG3858, COG3858, Predicted glycosyl hydrolase [General function prediction only].	2.19262e-135

>NZ_AP022557.1|WP_172418752.1|3397887_3398337_+|hut-operon-transcriptional-regulator-HutP
MGNEKSARIGRLALLLAMLDEGEEGPVLHQLESLVWRYCQGRVGAMEPQKIVAAIETAAKRHGVVDGGLYRDMHALYHAILEAVHGVTRGQMELGDLLRTAGLRFAVVRGTPYEGPKEGEWIAVALYGTIGAPVRGLEHEAVGLGINHI
>NZ_AP022557.1|WP_172418751.1|3397170_3397347_-|Arc-family-DNA-binding-protein
MTKKKPFPLRIDHELYAVLEQWAQEEFRSVNSHIEYLLREAAKRAGRLGKGKTDQKRS
>NZ_AP022557.1|WP_172418750.1|3395951_3396980_-|XdhC-family-protein
MESYYTVLEAIASAPSDGVVAIIIDVEGSAYQKEGTCMWIDANGETVGLLSGGCLEEAVAAHARDVLVSRQAAAVSFDLRTEDDWSWGQGAGCNGLIRVWLEPVTEDTKSVWLALKRCLDRSEHVLMARSIAHPKEPPFFQSETGERFGGYVSPPRPEWLNALHGTPFFRGRNGVQETDDGAFYIQHFWPKPRLVIFGAGPDAPPLVSAAKAAGFSVTVSDWRPAFCQPSHIPDADAWVVGFPHETVPMLHLTERDFVIMMTHQFERDRELIQWLADIPLAYLGVLGPRRRTDRLFPSGSAPPFVRSPVGLPIGARSPQEIAISIVAELISVLRGRPLEASR
>NZ_AP022557.1|WP_172418749.1|3395301_3395955_-|xanthine-dehydrogenase-accessory-protein-PucB
MNKGAIAAVYLAAGQSRRMGTDKRALPWGDGTLGAAGLKAALRSSLSPVIVVVPPNDALAWLPDALLRHDKCRLVRCAACHRGQAHSLACGLRAAMAEEADAAAVLLADQPFVTAETIDALAALYRRHRPDYLAFSRSGTPMPPVIWGKRTFPALLALEGDAGGRRLFHDPHWRGLFCEGDKWIGMDIDTYSDYERAVMEQKRKEESFHGCWEKCDP
>NZ_AP022557.1|WP_172418748.1|3393002_3395330_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MAVGKSVIRKEARDKVTGRAKYTNDFKQPGMLHAALVTSPYAHARIASIETSAALAAPGVRAVLTGEGLPLTGEDMRDRPPIAADKVRYFGEVVAVVVADTLAQAEQAARLIRVAYEPLPAVGSPREALKEGAPLLHEHLDRYEKNKTTHPEPGTNIAHRTKIRKGNIEQGFAESDVIIETSVSFNPSDHAAMETRCATAEIGPDGTISITASSQSPFMIKKLLHTYFGEDTGKIIVHTPLVGGAYGGKAPVQLELLAYLAAKAVGGRKVSVWNSREHDMVTSPVHIGLEATVKIGATNDGVFKAMEILFLFDGGAYSDKAIDVSRAAAVDCTGPYHVEHVWCDSLCVYTNRPYATPFRSFGHCEQSFAVERAIDELAKALRLDPWDVRRKNVIRPGHTTPTQVRLTKSNVGDMAACLDRLRELMRWDEWQRVELDAYTVRAKGISGGWKTSTIDTDASSGVILTFNSDGSVNLISGVVEIGTGTKTVLAQIVAERLNMNVDDVHVKMDIDTQTTPEHWKTVASRGTFMAGRAALAAADGAIRQLKEIAACVLRASPADLEVGFGRVFLRDDPAIFIPVKDIAYGYKFPNGNAIGGQVIGRGHYILRHLTPLDPETGAGKPGPEWGVCAEGVEVEFNRRDYTYRVVKAYAVIDAGKVLNPKAALGQAMGAMSMGLSFASREGFLFDQAQRVLNPQLRTYRPIRFGEHPVYIVEFVETPQIDAPYGARGIGEHGLIGMPAALANALSLAAGVPLNELPLVPELIWRKQKGDGYGSL
>NZ_AP022557.1|WP_033844627.1|3392179_3393016_-|FAD-binding-domain-containing-protein
MVPFDFAYYRPQSIAEATALFLELEQQGKQPLYYSGGTEILTLSRLGFVSTAAVIDIKEIPECRVLDADGDPLVLGAALALIELEETNPFPLLTKVTKEIADRTARNQITLGGNLCGQIFYREAATALLVAEADIVIAGPADIRQARINDLFHQQLQLGRGEFVVQFKVDRATATLPHFHRKRRKQGEVGYPLVTIAALKKDEAVRVAFSGICPFPFRSADVEAHLNDRNRPIGERIQAAIAAFPRPILHDIEGSADYRLFVAAQLLEDALRELGESI
>NZ_AP022557.1|WP_033844628.1|3391409_3391892_-|(2Fe-2S)-binding-protein
MEEPTKRELVLHINGEQRTVVVRQAETLLFVLRDHLGLTGAKPGCLNGDCGACTVLANGTPIKSCMILAIETVGKPITTIEGLDDAPIQHAFVRHFAFQCGYCTPGFIMNAQALIDRHPDADDAMIQEWLESNICRCTSYQEIEAAVKEVLKASKTSMTR
>NZ_AP022557.1|WP_033844630.1|3390111_3390537_-|MerR-family-transcriptional-regulator
MKRLKIDDVAKATGLTKRTIRYYEEIGLIKPPARSDGGTRLYTEEEIEQLKQIIAAREVLGFSLQELQHFLSLKEKIAVHRAELLQTADHEKRRELEQIAAGLRQQIAMLDEKMKKMETLKQELKQMEQRVNTILQEGREE
>NZ_AP022557.1|WP_033844631.1|3388954_3390112_-|MFS-transporter
MDEGRQTRARWITVAAAFLAFMGIGVVDPILPVIAESIGATHWQVEMLFTAYIFTMAVMMIPVGLIVSRVGDKQMMVIGLGLVTMFSLLCGFAANIPQLSLFRAGWGLGNATFFATAMTLLIALTPQASTAVGLYEAAIGLGMAGGPLIGGLLGQHSWRYPFLGTSVLIFIAFLLVALFVYDPNKGKPKKAAGWQEMRRLLAFPPFLKGAVGGMLYYYGFFVVLAYSPLIIHLSAIQIGLVFFGWGLCLAYGSAVLAHRLEERHEPKHLLPYSLLLFAVLLLLLAVAQPTWLTIVLIILSGLVSGVNNALFTSYVMESSPYERGVTSGMYNFVRWMGAAIAPVLSGVIGHALSVKAPFMVAMALALAAFLFLAWRKGEPSETKAA
>NZ_AP022557.1|WP_033844632.1|3387706_3388861_+|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein
MKVLVLGAGLMGKEAARDLVQSEAVEAVTLADVDRTKAERAARQLQSEKLSAVQADAGDQQQLSVLMKKHDVVVNALFYRFNETVAKTAIASGVHSVDLGGHIGHITDRVLELHDQAQAAGVTIIPDLGVAPGMINILSGYGASQLDEVESIQLYVGGIPVHPDPPLEYNHVFSLEGLLDHYTDPSLIIRDGKVQEVPSLSEIEPIYFERFGPLEAFHTSGGTSTLSRSFPNLKRLEYKTIRYRGHAEKFKLLVDLNLTRNDFEVEIGGRPIKPRDVLLAVLTPLLDLKGKDDVVLLRVIVGGRKEGKETVLEYETVTFNDRENNVTAMARTTAYTISAVAQLIGRGVIQKRGVYPPEQIVPGDVYIEEMKRRGVMIREKKTDR
>NZ_AP022557.1|WP_172418754.1|3400142_3401405_+|glycoside-hydrolase-family-18-protein
MFTHTVQPGDSLFSIGRRYDYSVEDLRIVNGLTASNIVPGQALLIPLYTYTVQPGDTLTAIARRAFVTLEQLQAANPHLQPNALRPGMKITIPNISWYQATTLGYYVVREPSADRTMIRDFAPYSSYITLFEYHFAPNGDVVNELDDVAAVREAWRNRVTPLVAITNLTTQGFSPILASRVLNNPEARTNLIENIFYLVSRKGYGGVNIDFEQIRGEDRDLFTGFLRQLRDRLKPAGYVVTIAVPAKTSENIPWLQGYDYGGIGAVVDYMFIMAYDWHHLASEPGPVAPIGGVRAALQFAVERVPRQKILLGLPLYGYDWVIPYRLGTIAKARSNQEAIHTAMRYQSFVQYSLADESPFFQYTDELGNVHEVWFEDIRSMGQKMKLAWQFQLAGVGAWQLTLRFAPGSWLLRKFFTIRKV
>NZ_AP022557.1|WP_061912375.1|3401683_3402370_+|TerC-family-protein
MTISAAALLALWKIIAIDIILSGDNAVVIAMATRRLPKDQQNKAIFWGTAGAVLLRLLFAAIIVFLLNIPFVHFVGGLLLVWIAYKVLVEREEEANVQSSDRLLKAIMTIIIADAVMSLDNVVAVAGAAEGHLGMLALGVAISIPIMIFGSKAIVRVMEQHRWVAYVGSGILAWTAGKMIVGDEGVLRLLHLSHGPFVYAVAAGVTIFVLAAGYIANKKAAREEGTLI
>NZ_AP022557.1|WP_172418755.1|3402393_3403326_+|D-2-hydroxyacid-dehydrogenase
MNIQRILVTGRLYAELASLLPDKRPDKAFRFVAEDELQEADFAWADAYIGFRPAGPFSLAHLRWVHSLGAGVDAFLWKREWKPDVLLTRTIGSFGEQIAEYCLSYLLRDAQCHDVYAWYQEQRQWKPVAPKRLSEQRMVIYGTGEIGRRIAETLRLFGVSPAGVSRSGRDTPSFSAVYRHEEAGEALARADWVIAALPLTEETHHLFDKTFFSCLHNAGFINVGRGATVEEAALVGALENRNVRLAVLDVFEEEPLPLHSPLWGHPHVIITPHIAALTAAEDAARSILDTLRRIETGEPLANAVDVSRQY
>NZ_AP022557.1|WP_061912374.1|3404456_3405002_+|hypothetical-protein
MFRPLQWKRLIASLIVFVAGLASLFVSGGSTATAFSLVASPASDRDLVAIQQTIVQALEARWRLMIDPQVNIKSFYDPDTSEQEESRERAYVRRHYLEPAARAGFRYTSVKVHPVFENVEISGKTAKVQVFVSVEYESMFPGSNEVVITKEANIPYFATLAKRDGHWLIVKVSGQDTYSKR
>NZ_AP022557.1|WP_153017136.1|3407345_3407558_+|hypothetical-protein
MQFYNITKLRYSHTVYATKRVWRSERGTYDILYCGHSSARLDYSLIDAFESSSYYTRLRVIKIYYGPLIA
>NZ_AP022557.1|WP_061912372.1|3408365_3409088_-|lactate-utilization-protein-C
MTRGTIQNRDAFLQTIAERLGRSPRLSGVSRPQWDDAPQWTVFAGYSQDDLLEALRQQCTLIHTDYIETTSAELAGVLKRQVSAYGGGPVIMPNDPRFAEYGLSSLLQEEWPAEQTDVHVWNPALGRQNIDAAEQANVGIAFSDITLAESGTVVLFSRNGQGRAIHFLPKTYIAIVPKSTIVPRMTQAAALIHEQIEQGALVPSCINFITGPSNSADIEMNLVVGVHGPMKAAYIIVTDR
>NZ_AP022557.1|WP_172418756.1|3409084_3410515_-|iron-sulfur-cluster-binding-protein
MPMKIENGPFWKRVEENLQNNFMRGAVAGMQDRGYVRRLGVIEELGHWEEWRSLAEQIRKHTLENLDYYLMQLSENVANRGGHVFFARTAEEANDYIRRIALEKQAKKIVKSKSMVTEEINLNPVLEAIGCDVVETDLGEYILQMDDHDPPSHIVGPALHKNKEQIRDVFRRKLGYTKSSDPVELARHARETLRRDYLTADIGITGCNFAIAESGSITLVTNEGNADLVTALPKTQITVMGMERIVPTFEEMEVLVSMLTRSAVGQKLTSYITVLTGPRDEGDADGPEEFHLVIVDNGRSSILGTEFQPVLQCIRCAACVNVCPVYRHIGGHSYGSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACTEACPVKIPLHELLIKHRQIIVEQEGKAPVAEKLAMKAFRLGTASPSLYRFGTKLAPSAFAPFAEDGRIRKGPGPLKAWTESREFPAPSKERFRDWFRNRQKGGNPS
>NZ_AP022557.1|WP_082799321.1|3410453_3411251_-|(Fe-S)-binding-protein
MKVSLFVTCLIDLFYTEAGKATVELLERLGCEIDFPEAQTCCGQPAYNSGYVQEAKEAMKQMMRAFADADYVVTPSGSCAAMVKEYPHLFRGDPEWEDEAKRLAAKTYELTQFLVDVLNVEDVGASLPGRATYHTSCHMTRLLGVKEAPLRLLEHVEGLELVPLPNAHQCCGFGGTFSVKMGPISEQMVDEKIAHIDEVDADYVIGADCGCLLNIGGRIERLGKPIRVMHIAEVLNQHSEKEGNDNADENRKRAVLETGRGKLAK
>NZ_AP022557.1|WP_082799322.1|3412138_3412738_-|response-regulator-transcription-factor
MKIKVLLVDDHLLVMHGIQKLLENEIDLEVVNTVCDPALLETEIKKHNPNVIVMDIRMKNDNGIEWVRKISKTYPTCKVVILSGYNYDEYIQAAYEAGAYAFVTKESSVFELANAIRQTYLGVKSFPIDRLDYCNSPLTKTELDILQLISEDKTNAEISELLHISRRTVEHHVSSILRKLDADSRVGAVVKAIKLGLIG
>NZ_AP022557.1|WP_061912607.1|3412709_3414797_-|histidine-kinase
MNKKVLPFSLILISIFIICYFLLKMYNEHVSPQRYFPIFIGMIFLLAGIYSYVQKPNSIVVQYFLALMFISGMAIALSSPSSENIKPARELEVVFISFAPYILLKFFEHFPSSAKPNFFRQVRILTLYMAIFITISYLFIGIHHHVIISTIVRPSIVANIILALLGCVILFYLHLRSNSNKIKNQIYLLIGSIMISFAPVVILNLIPNAFFSLPGAPFHYSLGSIVMFPLTLSYLLTRQEIIDFREILEKMMVRLFMIGCCLAIFNLLLSLFYDIHFKFCILVNTLLICLFIVYDLINKGLEPLQMRKWHGKQEEIQKEKLTILQELLNGKHLEYCAKLIADLIHKTIDVSGVCIVWKHDHSPTVLHKTGIFLHLHDSELLSYACQSSYFSKMTMNEKSVFFYPMTIDDALIGWMMIGEKTNATVFDNEEQKLMKKIQMDAIELFTSSKTLQQIENQLKKITEESRMSEQSHWLLLHEHEEEKRKLSTFLHDEVLQHLILLLNKLEWLIQKKNIDKKLFEDMKRLLQRDIFEIREMCHELYPVMVEDLGLKQGLSSLKRKCETNYNVIVEVNYIANLKIIQPFLSIQAFRIIKELVYNAIKHSSSRKIVVTVEETKQFLNIQVKDYGVGFKVPDHLLELSQTNHLGLITIQKRVHQLNGTLTIHSELGAGTCISVSLPITVEEGGGNENQSIISR

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Crispr_ID: NZ_AP022557_30

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_30

3417350-3417449

Orphan

Consensus_repeat	Method
TTTGCCCTCCACCCGGGGATGAAAATCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_30

>merge|NZ_AP022557|30|3417350-3417449|CRISPRCasFinder
TTTGCCCTCCACCCGGGGATGAAAATCCTGCGTCAGTTCGGCATTTTCACGGAAAAGATCCATGGGCAACGTTTTGCCCTCCACCCAGGGATGAAAATCC

>NZ_AP022557|30|29|3417350-3417449|CRISPRCasFinder
TTTGCCCTCCACCCGGGGATGAAAATCC	TGCGTCAGTTCGGCATTTTCACGGAAAAGATCCATGGGCAACGT
TTTGCCCTCCACCCAGGGATGAAAATCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_153017122.1\|3424291_3424477_+\|thiocillin-family-RiPP	unknown	unknown	unknown
NZ_AP022557.1\|WP_153017124.1\|3424090_3424264_+\|thiocillin-family-RiPP	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912365.1\|3415536_3416838_+\|YcaO-like-family-protein	unknown	unknown	gnl\|CDD\|274674
NZ_AP022557.1\|WP_172418760.1\|3424493_3424820_+\|thiocillin-family-RiPP	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418757.1\|3414804_3415161_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_153017136.1\|3407345_3407558_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912237.1\|3421629_3423333_+\|SagB-family-peptide-dehydrogenase	unknown	unknown	gnl\|CDD\|188352
NZ_AP022557.1\|WP_061912239.1\|3424947_3426063_+\|PqqD-family-peptide-modification-chaperone	unknown	unknown	gnl\|CDD\|100080
NZ_AP022557.1\|WP_172418756.1\|3409084_3410515_-\|iron-sulfur-cluster-binding-protein	unknown	unknown	gnl\|CDD\|224062
NZ_AP022557.1\|WP_061912374.1\|3404456_3405002_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912240.1\|3426077_3428576_+\|lantibiotic-dehydratase	unknown	unknown	gnl\|CDD\|377403
NZ_AP022557.1\|WP_061912241.1\|3428608_3429502_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372883
NZ_AP022557.1\|WP_082799322.1\|3412138_3412738_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_AP022557.1\|WP_061912238.1\|3423325_3423997_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|376405
NZ_AP022557.1\|WP_061912372.1\|3408365_3409088_-\|lactate-utilization-protein-C	unknown	unknown	gnl\|CDD\|224473
NZ_AP022557.1\|WP_033842531.1\|3417676_3418813_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_033842531.1\|3420038_3421175_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_061912607.1\|3412709_3414797_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_AP022557.1\|WP_082799321.1\|3410453_3411251_-\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NZ_AP022557.1\|WP_172418758.1\|3415167_3415332_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_061912365.1\|3415536_3416838_+\|YcaO-like-family-protein	gnl\|CDD\|274674	TIGR03604, hypothetical_protein, thiazole/oxazole-forming peptide maturase, SagD family component. Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.	1.7998e-102
NZ_AP022557.1\|WP_061912241.1\|3428608_3429502_+\|hypothetical-protein	gnl\|CDD\|372883	pfam14028, Lant_dehydr_C, Lantibiotic biosynthesis dehydratase C-term. Lant_dehydr_C is the C-terminal domain of a family of dehydratases that are involved in the biosynthesis of lantibiotics. While the extensive N-terminal domain, pfam04738, is involved in the serine-threonine glutamylation step of the synthetic process, this C-terminal domain, once thought to be a separate domain from the dehydratase enzymic activity, is necessary for the final glutamate-elimination step in the generation of the lantibiotic. Lantibiotics are a class of peptide antibiotic that contains one or more thioether bonds.	1.11629e-30
NZ_AP022557.1\|WP_061912239.1\|3424947_3426063_+\|PqqD-family-peptide-modification-chaperone	gnl\|CDD\|100080	cd06159, S2P-M50_PDZ_Arch, Uncharacterized Archaeal homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group appears to be limited to Archaeal S2P/M50s homologs with additional putative N-terminal transmembrane spanning regions, relative to the core protein, and either one or two PDZ domains present.	4.82912e-08
NZ_AP022557.1\|WP_061912237.1\|3421629_3423333_+\|SagB-family-peptide-dehydrogenase	gnl\|CDD\|188352	TIGR03605, antibiot_sagB, SagB-type dehydrogenase domain. SagB of Sterptococcus pyogenes participates in the maturation of streptolysin S from a ribosomally produced precursor polypeptide. Chemically similar systems operate on highly diverse sets of bacteriocin precursors in numerous other bacteria. This model describes a domain within SgaB and homologous regions from other proteins, many of which appear to be involved in biosynthesis of secondary metabolites. While some substrates may be intermediates in non-ribosomal peptide syntheses, others are involved in heterocycle-containing bacteriocin biosynthesis, and can be found near SgaC-like (see TIGR03603, cyclodehydratase) and SgaD-like (see TIGR03604, "docking") proteins. Members of this domain family are heterogeneous in length, as many have a partial second copy of the domain represented here. The incomplete second domain scores below the cutoffs to this model in most cases.	1.99161e-18
NZ_AP022557.1\|WP_172418756.1\|3409084_3410515_-\|iron-sulfur-cluster-binding-protein	gnl\|CDD\|224062	COG1139, COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion].	0
NZ_AP022557.1\|WP_061912240.1\|3426077_3428576_+\|lantibiotic-dehydratase	gnl\|CDD\|377403	pfam04738, Lant_dehydr_N, Lantibiotic dehydratase, C-terminus. Lantibiotics are ribosomally synthesized antimicrobial agents derived from ribosomally synthesized peptides. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues. This family constitutes the N-terminus of the enzyme proposed to catalyze the dehydration step, via glutamylation of the substrate during lantibiotic biosynthesis. The enzyme dehydrates Ser/Thr residues in the precursor by glutamylation.	1.1814e-13
NZ_AP022557.1\|WP_082799322.1\|3412138_3412738_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.19451e-55
NZ_AP022557.1\|WP_061912372.1\|3408365_3409088_-\|lactate-utilization-protein-C	gnl\|CDD\|224473	COG1556, COG1556, Uncharacterized conserved protein [Function unknown].	1.43656e-82
NZ_AP022557.1\|WP_033842531.1\|3417676_3418813_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_033842531.1\|3420038_3421175_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_061912607.1\|3412709_3414797_-\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.63853e-29
NZ_AP022557.1\|WP_082799321.1\|3410453_3411251_-\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	2.05194e-63
NZ_AP022557.1\|WP_061912238.1\|3423325_3423997_+\|nitroreductase-family-protein	gnl\|CDD\|376405	pfam00881, Nitroreductase, Nitroreductase family. The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	2.82218e-06

>NZ_AP022557.1|WP_061912365.1|3415536_3416838_+|YcaO-like-family-protein
MNKSIYDLCQPVGGLMTYPQLLPVAHGEPKYYICGSSLGDLSQIENLRYNNHGSQMELTGAGGDISYDMAKFKSLAETLERYCSCVFNEEQFIWATAEELGEDALDLDQIPVCSENELKHPMCPILKPNKKEKIRWVRGISLTSKKLVWVPAIMVYLYIPYKSEGERFWIPISTGCAIHTSYEAALINAINEVIERDAISLTWLHRLPLDKIEIDISLPDWAESYLAKNKEYSYFETYYYNATTDLGIPTIYSVQFSPHNPKLSTVVMCSTELDPLVALTKITREAASVRIALQHKEVKGTDIDTFRDVFEGALYMGSSSMMKEFDFLKYSQGRYPFSKFPNYATNDSKQDLNFLIERLKEKKHEVIAVDLTTDEAAHCGFHAVRVIIPTLQPLSFTYRARYLGTKRLYQAPIDMGYGVRTEEQINPFPQPFA
>NZ_AP022557.1|WP_172418758.1|3415167_3415332_-|hypothetical-protein
MKQNLWDVLQELLEKDVIGATELALAKERLSPQEFSALAAYLQDSSKKEGNLWV
>NZ_AP022557.1|WP_172418757.1|3414804_3415161_-|hypothetical-protein
MNRIEKSAIRTFLQNHLLTNCMLEKEIIQYIFHLLHGKGKIFSTDETHFSWGGGFYAQVSSFHLKDDTCIQSIISHAAAIELLILLSKIYMDKAFRQIATHFPDKQIQIARLKRYLES
>NZ_AP022557.1|WP_061912607.1|3412709_3414797_-|histidine-kinase
MNKKVLPFSLILISIFIICYFLLKMYNEHVSPQRYFPIFIGMIFLLAGIYSYVQKPNSIVVQYFLALMFISGMAIALSSPSSENIKPARELEVVFISFAPYILLKFFEHFPSSAKPNFFRQVRILTLYMAIFITISYLFIGIHHHVIISTIVRPSIVANIILALLGCVILFYLHLRSNSNKIKNQIYLLIGSIMISFAPVVILNLIPNAFFSLPGAPFHYSLGSIVMFPLTLSYLLTRQEIIDFREILEKMMVRLFMIGCCLAIFNLLLSLFYDIHFKFCILVNTLLICLFIVYDLINKGLEPLQMRKWHGKQEEIQKEKLTILQELLNGKHLEYCAKLIADLIHKTIDVSGVCIVWKHDHSPTVLHKTGIFLHLHDSELLSYACQSSYFSKMTMNEKSVFFYPMTIDDALIGWMMIGEKTNATVFDNEEQKLMKKIQMDAIELFTSSKTLQQIENQLKKITEESRMSEQSHWLLLHEHEEEKRKLSTFLHDEVLQHLILLLNKLEWLIQKKNIDKKLFEDMKRLLQRDIFEIREMCHELYPVMVEDLGLKQGLSSLKRKCETNYNVIVEVNYIANLKIIQPFLSIQAFRIIKELVYNAIKHSSSRKIVVTVEETKQFLNIQVKDYGVGFKVPDHLLELSQTNHLGLITIQKRVHQLNGTLTIHSELGAGTCISVSLPITVEEGGGNENQSIISR
>NZ_AP022557.1|WP_082799322.1|3412138_3412738_-|response-regulator-transcription-factor
MKIKVLLVDDHLLVMHGIQKLLENEIDLEVVNTVCDPALLETEIKKHNPNVIVMDIRMKNDNGIEWVRKISKTYPTCKVVILSGYNYDEYIQAAYEAGAYAFVTKESSVFELANAIRQTYLGVKSFPIDRLDYCNSPLTKTELDILQLISEDKTNAEISELLHISRRTVEHHVSSILRKLDADSRVGAVVKAIKLGLIG
>NZ_AP022557.1|WP_082799321.1|3410453_3411251_-|(Fe-S)-binding-protein
MKVSLFVTCLIDLFYTEAGKATVELLERLGCEIDFPEAQTCCGQPAYNSGYVQEAKEAMKQMMRAFADADYVVTPSGSCAAMVKEYPHLFRGDPEWEDEAKRLAAKTYELTQFLVDVLNVEDVGASLPGRATYHTSCHMTRLLGVKEAPLRLLEHVEGLELVPLPNAHQCCGFGGTFSVKMGPISEQMVDEKIAHIDEVDADYVIGADCGCLLNIGGRIERLGKPIRVMHIAEVLNQHSEKEGNDNADENRKRAVLETGRGKLAK
>NZ_AP022557.1|WP_172418756.1|3409084_3410515_-|iron-sulfur-cluster-binding-protein
MPMKIENGPFWKRVEENLQNNFMRGAVAGMQDRGYVRRLGVIEELGHWEEWRSLAEQIRKHTLENLDYYLMQLSENVANRGGHVFFARTAEEANDYIRRIALEKQAKKIVKSKSMVTEEINLNPVLEAIGCDVVETDLGEYILQMDDHDPPSHIVGPALHKNKEQIRDVFRRKLGYTKSSDPVELARHARETLRRDYLTADIGITGCNFAIAESGSITLVTNEGNADLVTALPKTQITVMGMERIVPTFEEMEVLVSMLTRSAVGQKLTSYITVLTGPRDEGDADGPEEFHLVIVDNGRSSILGTEFQPVLQCIRCAACVNVCPVYRHIGGHSYGSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACTEACPVKIPLHELLIKHRQIIVEQEGKAPVAEKLAMKAFRLGTASPSLYRFGTKLAPSAFAPFAEDGRIRKGPGPLKAWTESREFPAPSKERFRDWFRNRQKGGNPS
>NZ_AP022557.1|WP_061912372.1|3408365_3409088_-|lactate-utilization-protein-C
MTRGTIQNRDAFLQTIAERLGRSPRLSGVSRPQWDDAPQWTVFAGYSQDDLLEALRQQCTLIHTDYIETTSAELAGVLKRQVSAYGGGPVIMPNDPRFAEYGLSSLLQEEWPAEQTDVHVWNPALGRQNIDAAEQANVGIAFSDITLAESGTVVLFSRNGQGRAIHFLPKTYIAIVPKSTIVPRMTQAAALIHEQIEQGALVPSCINFITGPSNSADIEMNLVVGVHGPMKAAYIIVTDR
>NZ_AP022557.1|WP_153017136.1|3407345_3407558_+|hypothetical-protein
MQFYNITKLRYSHTVYATKRVWRSERGTYDILYCGHSSARLDYSLIDAFESSSYYTRLRVIKIYYGPLIA
>NZ_AP022557.1|WP_061912374.1|3404456_3405002_+|hypothetical-protein
MFRPLQWKRLIASLIVFVAGLASLFVSGGSTATAFSLVASPASDRDLVAIQQTIVQALEARWRLMIDPQVNIKSFYDPDTSEQEESRERAYVRRHYLEPAARAGFRYTSVKVHPVFENVEISGKTAKVQVFVSVEYESMFPGSNEVVITKEANIPYFATLAKRDGHWLIVKVSGQDTYSKR
>NZ_AP022557.1|WP_033842531.1|3417676_3418813_+|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_033842531.1|3420038_3421175_+|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_061912237.1|3421629_3423333_+|SagB-family-peptide-dehydrogenase
MKTLNKIDAKEIGMAVSYDPQFRMPIRPKVSKYVNLVSCGDDGVIFDGSPEKQLFRGSAVKKFLYDLISLADGTRTVQEIAETLDTYPSQFIYNALALLYSRGLLQEGTSSHYLEDTPYYKFIERHIDVTRVNLHPTEAIERLHAYSVFIHGKPDDVQYLSNELRQYDISIVDHITPFTEDSKLFAIAICDDINDLMEIKPFASQCYEYSIPWILITFSHKKIYVGPYFERNETLCFECYLKQMNRIDEISIGTNTEMTDPLLKKIGLDYSGIEVVHLLSRIASSHLIHNLKKVDIETFEYTPINVSKLPFCEWCDPIKGMEPTINLVSQYEGYIAFPSSHLINPKDHQNHYKLGNLELAKSSIVYPSCQHINLPHQDSLPDLNSNPRNFSGLQLLTKLMLLTAGLKKNVKNNNPRVYRWAPTGGNLGSVGVYFVNKGVKELQKGVYFYQTSTHTLAQLNGSFEEEVLEKITIDSRLSRGTLLGYLIFSGSYDRVYKKYKEFAYKIIHLDAGVAYAQSQVVAQLLGLELQLCESWNNDEIEHLLRLDHLNEPVTLVATLHRRGESND
>NZ_AP022557.1|WP_061912238.1|3423325_3423997_+|nitroreductase-family-protein
MTKVIPRSEIVMKLIEDSKEFKKHIVAEGPLVKIFDIGLPNRGRSIEQVFFERTSYRFFHPNSEVDIEDLKTILLKNHQYYIHNWNDDRLVQQYIIGERVNHASINARTIYRYCPDTNDLSAEGYLPENVSKKMLFLQQEFADAPVVLLFVGELAKAVEKIGTAGYKNLLMRAGAVAHYSWLQSMSMGYQGTVFAGVLPKMFKKFCSIDGYRKCQMFAYAFGN
>NZ_AP022557.1|WP_153017124.1|3424090_3424264_+|thiocillin-family-RiPP
MERMENTTLELYAEELPDITQYTAAGTSTLSTESSVLSASCPTSTVSTYTSMSSYSW
>NZ_AP022557.1|WP_153017122.1|3424291_3424477_+|thiocillin-family-RiPP
MNREDNNVSFVELELFAEELPEQHNFMASCCWGSIACFTSASTFGSCAATASCSSTASCAC
>NZ_AP022557.1|WP_172418760.1|3424493_3424820_+|thiocillin-family-RiPP
MTEKIHGQWFALHPGMKILRQFGIFTEKIHGQWFALHPGMKIRASAAFSRKMNENLDDLELYAEEMPEQLNFTAAAATVASFFCGASIACAGSCGSSFSSTSTLSTAG
>NZ_AP022557.1|WP_061912239.1|3424947_3426063_+|PqqD-family-peptide-modification-chaperone
MDISFKIKESNSNFSLSNPLFLSKDVKMFEVDDETLLFHGQTRKYYKIGKIAKELISQLQTQQSTGEQLVKEISIRFDVKTEEITKNVNEFLKQMIEEGIICTNEGRFDRNKSVHSQRSNKALIKLIKMKNFDRYLSKLSSLLPTMSIKATAVFFILMSVISIVSIISVLRSNYVAPLSGIEFFYLLPWITLHLIGHELSHALVCKKLGGDVREIGFGLLYLVIPVAYVDLTDTYQLKSNKRAFIAVTDPVYDLTMAFISSLFVLYLDGFPKTIAVHFLLIQFMIFCFNCNLLLPSDLYKALENWFKVTNLRNHSLEYLKFTMMNKEKPAYLKGISGIKENFYLLYAILSLFYIASLIFIFVFYYFKIFFD
>NZ_AP022557.1|WP_061912240.1|3426077_3428576_+|lantibiotic-dehydratase
MSGIPTVSNFLLARLAVNSTEILDHMICHQTGNVIREFLRVENELLQLKQPMIDLLYNIVPSLEDQKKLIRFVIKLKRDIFNDRNDRLQKIKEYDYLVLSKYLNEEENIILNTWLRLYKERKGLADKMRQIFNDEKKTIVNWLKEYLKNEESEEFRKGLALASPDLLKILPKGLNDLVHFGSNLSKSIYMYLQRSIIKTSPFSTLTQISTTNFDPLRTVKELDSEFETRHSIRMNRAIVTTVIEELSKHESFNKYFKFQFTTSADAGGKKARITSKYMYTNNFFWKTEETKTLLSSPILSALDQFDEGTEYTLEQILNSLGSNKEYAKYLMFSLKLLRPVVPFDIYEEEPLKKTADLITSNGNGDELVQEVSKHLYRANDLFKELKIGCTGLQRVEKLGKLRIEMKRLFCLLKRNPPQWMEHANLVYEDVRSQIEVPHLGQQVYEDVYKIIEMLRPYFHFSSLYSELLDYFKSTYGPGKEIMLVDFLATLTSNEQLLYRMFERASVRDFQKQKNKTVKGPNIAPPTACIYFQLSAGSQEDLLNGNYLIVVNKISTGLGNVFSRFNPLFKKHPYSGHLKEWIEGLFPLSEPVELSMGGDWSNLQECFGVLTRNIDWFGECKYGSTHYQMKNISISHCQITDSLVLKAQDGNTVSPVYLGTVPQYLIQGSGKILLTLINPWMIDAPYGINPRPWEKIKGVDGIQYIPRQQQGRIVLKRAQWIIPTELLPSFEKSDDDVEVMLKLQRFIDKYQIPTEVFLTMTEKTTSLHGSKPVWIHFHSPYSIEILKRNVTQDTEYIVFTEALPDHRTCWMQNKRGQPIISEFMCLGKLTDHT
>NZ_AP022557.1|WP_061912241.1|3428608_3429502_+|hypothetical-protein
MNQEWIYYNIYPSNSSLMDFVVEDIVRNAYLEVGKITEISKWFFIRYQDHSGTHVRLRFLVSVESLNEVIGILEKLFEEKLTKISRITHYEPKRLIPMKSSQQFNSEQESRFELALYEPEIDKYGGKTGLSISEELFQYSSEICLDVTPGIIDGTLNRFIIGLKYMNESIHAIFERTDTILAFLEKYISYWSGEHYSAIGTTYKNNFIQSAEKRVALTKNIIEQDYHHMNFEKYGKLLKSVIDRINAVNMDKTPEDLLFHYIHMMNNRLGIWPVEEAYLAALLNSFYMNQPMQGAAN

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Crispr_ID: NZ_AP022557_31

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_31

3421344-3421441

Orphan

Consensus_repeat	Method
TGCCCTCCACCCGGGGATGAAAATCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_31

>merge|NZ_AP022557|31|3421344-3421441|CRISPRCasFinder
TGCCCTCCACCCGGGGATGAAAATCCTACGCCAGTCCTGCATTTTCACGGAAAAGATCCATGGGCAATGGTTTGCCCTCCACCCGGGGATGAAAATCC

>NZ_AP022557|31|30|3421344-3421441|CRISPRCasFinder
TGCCCTCCACCCGGGGATGAAAATCC	TACGCCAGTCCTGCATTTTCACGGAAAAGATCCATGGGCAATGGTT
TGCCCTCCACCCGGGGATGAAAATCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_172418759.1\|3416859_3417597_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200298
NZ_AP022557.1\|WP_153017124.1\|3424090_3424264_+\|thiocillin-family-RiPP	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912365.1\|3415536_3416838_+\|YcaO-like-family-protein	unknown	unknown	gnl\|CDD\|274674
NZ_AP022557.1\|WP_172418760.1\|3424493_3424820_+\|thiocillin-family-RiPP	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418757.1\|3414804_3415161_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912243.1\|3430251_3431034_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|130314
NZ_AP022557.1\|WP_061912237.1\|3421629_3423333_+\|SagB-family-peptide-dehydrogenase	unknown	unknown	gnl\|CDD\|188352
NZ_AP022557.1\|WP_061912239.1\|3424947_3426063_+\|PqqD-family-peptide-modification-chaperone	unknown	unknown	gnl\|CDD\|100080
NZ_AP022557.1\|WP_172418756.1\|3409084_3410515_-\|iron-sulfur-cluster-binding-protein	unknown	unknown	gnl\|CDD\|224062
NZ_AP022557.1\|WP_061912241.1\|3428608_3429502_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372883
NZ_AP022557.1\|WP_061912240.1\|3426077_3428576_+\|lantibiotic-dehydratase	unknown	unknown	gnl\|CDD\|377403
NZ_AP022557.1\|WP_153017122.1\|3424291_3424477_+\|thiocillin-family-RiPP	unknown	unknown	unknown
NZ_AP022557.1\|WP_033842531.1\|3417676_3418813_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_061912238.1\|3423325_3423997_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|376405
NZ_AP022557.1\|WP_082799322.1\|3412138_3412738_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_AP022557.1\|WP_033842531.1\|3420038_3421175_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_061912607.1\|3412709_3414797_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_AP022557.1\|WP_082799321.1\|3410453_3411251_-\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NZ_AP022557.1\|WP_172418758.1\|3415167_3415332_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912242.1\|3429515_3430250_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_061912607.1\|3412709_3414797_-\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.63853e-29
NZ_AP022557.1\|WP_061912365.1\|3415536_3416838_+\|YcaO-like-family-protein	gnl\|CDD\|274674	TIGR03604, hypothetical_protein, thiazole/oxazole-forming peptide maturase, SagD family component. Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.	1.7998e-102
NZ_AP022557.1\|WP_061912241.1\|3428608_3429502_+\|hypothetical-protein	gnl\|CDD\|372883	pfam14028, Lant_dehydr_C, Lantibiotic biosynthesis dehydratase C-term. Lant_dehydr_C is the C-terminal domain of a family of dehydratases that are involved in the biosynthesis of lantibiotics. While the extensive N-terminal domain, pfam04738, is involved in the serine-threonine glutamylation step of the synthetic process, this C-terminal domain, once thought to be a separate domain from the dehydratase enzymic activity, is necessary for the final glutamate-elimination step in the generation of the lantibiotic. Lantibiotics are a class of peptide antibiotic that contains one or more thioether bonds.	1.11629e-30
NZ_AP022557.1\|WP_061912243.1\|3430251_3431034_+\|ABC-transporter-permease	gnl\|CDD\|130314	TIGR01247, drrB, daunorubicin resistance ABC transporter membrane protein. This model describes daunorubicin resistance ABC transporter, membrane associated protein in bacteria and archaea. The protein associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	3.80447e-11
NZ_AP022557.1\|WP_061912239.1\|3424947_3426063_+\|PqqD-family-peptide-modification-chaperone	gnl\|CDD\|100080	cd06159, S2P-M50_PDZ_Arch, Uncharacterized Archaeal homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group appears to be limited to Archaeal S2P/M50s homologs with additional putative N-terminal transmembrane spanning regions, relative to the core protein, and either one or two PDZ domains present.	4.82912e-08
NZ_AP022557.1\|WP_061912237.1\|3421629_3423333_+\|SagB-family-peptide-dehydrogenase	gnl\|CDD\|188352	TIGR03605, antibiot_sagB, SagB-type dehydrogenase domain. SagB of Sterptococcus pyogenes participates in the maturation of streptolysin S from a ribosomally produced precursor polypeptide. Chemically similar systems operate on highly diverse sets of bacteriocin precursors in numerous other bacteria. This model describes a domain within SgaB and homologous regions from other proteins, many of which appear to be involved in biosynthesis of secondary metabolites. While some substrates may be intermediates in non-ribosomal peptide syntheses, others are involved in heterocycle-containing bacteriocin biosynthesis, and can be found near SgaC-like (see TIGR03603, cyclodehydratase) and SgaD-like (see TIGR03604, "docking") proteins. Members of this domain family are heterogeneous in length, as many have a partial second copy of the domain represented here. The incomplete second domain scores below the cutoffs to this model in most cases.	1.99161e-18
NZ_AP022557.1\|WP_172418756.1\|3409084_3410515_-\|iron-sulfur-cluster-binding-protein	gnl\|CDD\|224062	COG1139, COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion].	0
NZ_AP022557.1\|WP_061912240.1\|3426077_3428576_+\|lantibiotic-dehydratase	gnl\|CDD\|377403	pfam04738, Lant_dehydr_N, Lantibiotic dehydratase, C-terminus. Lantibiotics are ribosomally synthesized antimicrobial agents derived from ribosomally synthesized peptides. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues. This family constitutes the N-terminus of the enzyme proposed to catalyze the dehydration step, via glutamylation of the substrate during lantibiotic biosynthesis. The enzyme dehydrates Ser/Thr residues in the precursor by glutamylation.	1.1814e-13
NZ_AP022557.1\|WP_033842531.1\|3417676_3418813_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_061912242.1\|3429515_3430250_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	9.85206e-87
NZ_AP022557.1\|WP_082799322.1\|3412138_3412738_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.19451e-55
NZ_AP022557.1\|WP_033842531.1\|3420038_3421175_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_172418759.1\|3416859_3417597_+\|hypothetical-protein	gnl\|CDD\|200298	TIGR03603, cyclo_dehy_ocin, thiazole/oxazole-forming peptide maturase, SagC family component. Members of this protein family include enzymes related to SagC, a protein involved in thiazole/oxazole cyclodehydration modifications during biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Recent evidence suggests that the YcaO/SagD-like component, not this component, performs an ATP-dependent cyclodehydration. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins. Note that this model does not find all possible examples of bacteriocin biosynthesis cyclodehydratases, an in particular misses the E. coli plasmid protein McbB of microcin B17 biosynthesis. [Cellular processes, Pathogenesis].	6.07849e-07
NZ_AP022557.1\|WP_082799321.1\|3410453_3411251_-\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	2.05194e-63
NZ_AP022557.1\|WP_061912238.1\|3423325_3423997_+\|nitroreductase-family-protein	gnl\|CDD\|376405	pfam00881, Nitroreductase, Nitroreductase family. The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	2.82218e-06

>NZ_AP022557.1|WP_033842531.1|3420038_3421175_+|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_033842531.1|3417676_3418813_+|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_172418759.1|3416859_3417597_+|hypothetical-protein
MKIQLFEIGEFANRIGGLLSKRLETDRIKVEDNDFEKLPVRYDADLYVVISEHLCVDLCKYIDNINHNYKKCFLPIVVDHPYLTVGPFVQYGQGACYHCYYERFMQHNPIPHVTRALERHYSEFIGKGPKGYHPLDVAIVSNWLFYSVKNSFNHFQGKDPWAMVCPPPGDENPASVRHFHGKDPWATFCPPPRDENPPFLPIMKNRRKQFNRTLCLMVAWTLYGKVFESTGCTTHCPPFPVIEER
>NZ_AP022557.1|WP_061912365.1|3415536_3416838_+|YcaO-like-family-protein
MNKSIYDLCQPVGGLMTYPQLLPVAHGEPKYYICGSSLGDLSQIENLRYNNHGSQMELTGAGGDISYDMAKFKSLAETLERYCSCVFNEEQFIWATAEELGEDALDLDQIPVCSENELKHPMCPILKPNKKEKIRWVRGISLTSKKLVWVPAIMVYLYIPYKSEGERFWIPISTGCAIHTSYEAALINAINEVIERDAISLTWLHRLPLDKIEIDISLPDWAESYLAKNKEYSYFETYYYNATTDLGIPTIYSVQFSPHNPKLSTVVMCSTELDPLVALTKITREAASVRIALQHKEVKGTDIDTFRDVFEGALYMGSSSMMKEFDFLKYSQGRYPFSKFPNYATNDSKQDLNFLIERLKEKKHEVIAVDLTTDEAAHCGFHAVRVIIPTLQPLSFTYRARYLGTKRLYQAPIDMGYGVRTEEQINPFPQPFA
>NZ_AP022557.1|WP_172418758.1|3415167_3415332_-|hypothetical-protein
MKQNLWDVLQELLEKDVIGATELALAKERLSPQEFSALAAYLQDSSKKEGNLWV
>NZ_AP022557.1|WP_172418757.1|3414804_3415161_-|hypothetical-protein
MNRIEKSAIRTFLQNHLLTNCMLEKEIIQYIFHLLHGKGKIFSTDETHFSWGGGFYAQVSSFHLKDDTCIQSIISHAAAIELLILLSKIYMDKAFRQIATHFPDKQIQIARLKRYLES
>NZ_AP022557.1|WP_061912607.1|3412709_3414797_-|histidine-kinase
MNKKVLPFSLILISIFIICYFLLKMYNEHVSPQRYFPIFIGMIFLLAGIYSYVQKPNSIVVQYFLALMFISGMAIALSSPSSENIKPARELEVVFISFAPYILLKFFEHFPSSAKPNFFRQVRILTLYMAIFITISYLFIGIHHHVIISTIVRPSIVANIILALLGCVILFYLHLRSNSNKIKNQIYLLIGSIMISFAPVVILNLIPNAFFSLPGAPFHYSLGSIVMFPLTLSYLLTRQEIIDFREILEKMMVRLFMIGCCLAIFNLLLSLFYDIHFKFCILVNTLLICLFIVYDLINKGLEPLQMRKWHGKQEEIQKEKLTILQELLNGKHLEYCAKLIADLIHKTIDVSGVCIVWKHDHSPTVLHKTGIFLHLHDSELLSYACQSSYFSKMTMNEKSVFFYPMTIDDALIGWMMIGEKTNATVFDNEEQKLMKKIQMDAIELFTSSKTLQQIENQLKKITEESRMSEQSHWLLLHEHEEEKRKLSTFLHDEVLQHLILLLNKLEWLIQKKNIDKKLFEDMKRLLQRDIFEIREMCHELYPVMVEDLGLKQGLSSLKRKCETNYNVIVEVNYIANLKIIQPFLSIQAFRIIKELVYNAIKHSSSRKIVVTVEETKQFLNIQVKDYGVGFKVPDHLLELSQTNHLGLITIQKRVHQLNGTLTIHSELGAGTCISVSLPITVEEGGGNENQSIISR
>NZ_AP022557.1|WP_082799322.1|3412138_3412738_-|response-regulator-transcription-factor
MKIKVLLVDDHLLVMHGIQKLLENEIDLEVVNTVCDPALLETEIKKHNPNVIVMDIRMKNDNGIEWVRKISKTYPTCKVVILSGYNYDEYIQAAYEAGAYAFVTKESSVFELANAIRQTYLGVKSFPIDRLDYCNSPLTKTELDILQLISEDKTNAEISELLHISRRTVEHHVSSILRKLDADSRVGAVVKAIKLGLIG
>NZ_AP022557.1|WP_082799321.1|3410453_3411251_-|(Fe-S)-binding-protein
MKVSLFVTCLIDLFYTEAGKATVELLERLGCEIDFPEAQTCCGQPAYNSGYVQEAKEAMKQMMRAFADADYVVTPSGSCAAMVKEYPHLFRGDPEWEDEAKRLAAKTYELTQFLVDVLNVEDVGASLPGRATYHTSCHMTRLLGVKEAPLRLLEHVEGLELVPLPNAHQCCGFGGTFSVKMGPISEQMVDEKIAHIDEVDADYVIGADCGCLLNIGGRIERLGKPIRVMHIAEVLNQHSEKEGNDNADENRKRAVLETGRGKLAK
>NZ_AP022557.1|WP_172418756.1|3409084_3410515_-|iron-sulfur-cluster-binding-protein
MPMKIENGPFWKRVEENLQNNFMRGAVAGMQDRGYVRRLGVIEELGHWEEWRSLAEQIRKHTLENLDYYLMQLSENVANRGGHVFFARTAEEANDYIRRIALEKQAKKIVKSKSMVTEEINLNPVLEAIGCDVVETDLGEYILQMDDHDPPSHIVGPALHKNKEQIRDVFRRKLGYTKSSDPVELARHARETLRRDYLTADIGITGCNFAIAESGSITLVTNEGNADLVTALPKTQITVMGMERIVPTFEEMEVLVSMLTRSAVGQKLTSYITVLTGPRDEGDADGPEEFHLVIVDNGRSSILGTEFQPVLQCIRCAACVNVCPVYRHIGGHSYGSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACTEACPVKIPLHELLIKHRQIIVEQEGKAPVAEKLAMKAFRLGTASPSLYRFGTKLAPSAFAPFAEDGRIRKGPGPLKAWTESREFPAPSKERFRDWFRNRQKGGNPS
>NZ_AP022557.1|WP_061912237.1|3421629_3423333_+|SagB-family-peptide-dehydrogenase
MKTLNKIDAKEIGMAVSYDPQFRMPIRPKVSKYVNLVSCGDDGVIFDGSPEKQLFRGSAVKKFLYDLISLADGTRTVQEIAETLDTYPSQFIYNALALLYSRGLLQEGTSSHYLEDTPYYKFIERHIDVTRVNLHPTEAIERLHAYSVFIHGKPDDVQYLSNELRQYDISIVDHITPFTEDSKLFAIAICDDINDLMEIKPFASQCYEYSIPWILITFSHKKIYVGPYFERNETLCFECYLKQMNRIDEISIGTNTEMTDPLLKKIGLDYSGIEVVHLLSRIASSHLIHNLKKVDIETFEYTPINVSKLPFCEWCDPIKGMEPTINLVSQYEGYIAFPSSHLINPKDHQNHYKLGNLELAKSSIVYPSCQHINLPHQDSLPDLNSNPRNFSGLQLLTKLMLLTAGLKKNVKNNNPRVYRWAPTGGNLGSVGVYFVNKGVKELQKGVYFYQTSTHTLAQLNGSFEEEVLEKITIDSRLSRGTLLGYLIFSGSYDRVYKKYKEFAYKIIHLDAGVAYAQSQVVAQLLGLELQLCESWNNDEIEHLLRLDHLNEPVTLVATLHRRGESND
>NZ_AP022557.1|WP_061912238.1|3423325_3423997_+|nitroreductase-family-protein
MTKVIPRSEIVMKLIEDSKEFKKHIVAEGPLVKIFDIGLPNRGRSIEQVFFERTSYRFFHPNSEVDIEDLKTILLKNHQYYIHNWNDDRLVQQYIIGERVNHASINARTIYRYCPDTNDLSAEGYLPENVSKKMLFLQQEFADAPVVLLFVGELAKAVEKIGTAGYKNLLMRAGAVAHYSWLQSMSMGYQGTVFAGVLPKMFKKFCSIDGYRKCQMFAYAFGN
>NZ_AP022557.1|WP_153017124.1|3424090_3424264_+|thiocillin-family-RiPP
MERMENTTLELYAEELPDITQYTAAGTSTLSTESSVLSASCPTSTVSTYTSMSSYSW
>NZ_AP022557.1|WP_153017122.1|3424291_3424477_+|thiocillin-family-RiPP
MNREDNNVSFVELELFAEELPEQHNFMASCCWGSIACFTSASTFGSCAATASCSSTASCAC
>NZ_AP022557.1|WP_172418760.1|3424493_3424820_+|thiocillin-family-RiPP
MTEKIHGQWFALHPGMKILRQFGIFTEKIHGQWFALHPGMKIRASAAFSRKMNENLDDLELYAEEMPEQLNFTAAAATVASFFCGASIACAGSCGSSFSSTSTLSTAG
>NZ_AP022557.1|WP_061912239.1|3424947_3426063_+|PqqD-family-peptide-modification-chaperone
MDISFKIKESNSNFSLSNPLFLSKDVKMFEVDDETLLFHGQTRKYYKIGKIAKELISQLQTQQSTGEQLVKEISIRFDVKTEEITKNVNEFLKQMIEEGIICTNEGRFDRNKSVHSQRSNKALIKLIKMKNFDRYLSKLSSLLPTMSIKATAVFFILMSVISIVSIISVLRSNYVAPLSGIEFFYLLPWITLHLIGHELSHALVCKKLGGDVREIGFGLLYLVIPVAYVDLTDTYQLKSNKRAFIAVTDPVYDLTMAFISSLFVLYLDGFPKTIAVHFLLIQFMIFCFNCNLLLPSDLYKALENWFKVTNLRNHSLEYLKFTMMNKEKPAYLKGISGIKENFYLLYAILSLFYIASLIFIFVFYYFKIFFD
>NZ_AP022557.1|WP_061912240.1|3426077_3428576_+|lantibiotic-dehydratase
MSGIPTVSNFLLARLAVNSTEILDHMICHQTGNVIREFLRVENELLQLKQPMIDLLYNIVPSLEDQKKLIRFVIKLKRDIFNDRNDRLQKIKEYDYLVLSKYLNEEENIILNTWLRLYKERKGLADKMRQIFNDEKKTIVNWLKEYLKNEESEEFRKGLALASPDLLKILPKGLNDLVHFGSNLSKSIYMYLQRSIIKTSPFSTLTQISTTNFDPLRTVKELDSEFETRHSIRMNRAIVTTVIEELSKHESFNKYFKFQFTTSADAGGKKARITSKYMYTNNFFWKTEETKTLLSSPILSALDQFDEGTEYTLEQILNSLGSNKEYAKYLMFSLKLLRPVVPFDIYEEEPLKKTADLITSNGNGDELVQEVSKHLYRANDLFKELKIGCTGLQRVEKLGKLRIEMKRLFCLLKRNPPQWMEHANLVYEDVRSQIEVPHLGQQVYEDVYKIIEMLRPYFHFSSLYSELLDYFKSTYGPGKEIMLVDFLATLTSNEQLLYRMFERASVRDFQKQKNKTVKGPNIAPPTACIYFQLSAGSQEDLLNGNYLIVVNKISTGLGNVFSRFNPLFKKHPYSGHLKEWIEGLFPLSEPVELSMGGDWSNLQECFGVLTRNIDWFGECKYGSTHYQMKNISISHCQITDSLVLKAQDGNTVSPVYLGTVPQYLIQGSGKILLTLINPWMIDAPYGINPRPWEKIKGVDGIQYIPRQQQGRIVLKRAQWIIPTELLPSFEKSDDDVEVMLKLQRFIDKYQIPTEVFLTMTEKTTSLHGSKPVWIHFHSPYSIEILKRNVTQDTEYIVFTEALPDHRTCWMQNKRGQPIISEFMCLGKLTDHT
>NZ_AP022557.1|WP_061912241.1|3428608_3429502_+|hypothetical-protein
MNQEWIYYNIYPSNSSLMDFVVEDIVRNAYLEVGKITEISKWFFIRYQDHSGTHVRLRFLVSVESLNEVIGILEKLFEEKLTKISRITHYEPKRLIPMKSSQQFNSEQESRFELALYEPEIDKYGGKTGLSISEELFQYSSEICLDVTPGIIDGTLNRFIIGLKYMNESIHAIFERTDTILAFLEKYISYWSGEHYSAIGTTYKNNFIQSAEKRVALTKNIIEQDYHHMNFEKYGKLLKSVIDRINAVNMDKTPEDLLFHYIHMMNNRLGIWPVEEAYLAALLNSFYMNQPMQGAAN
>NZ_AP022557.1|WP_061912242.1|3429515_3430250_+|ABC-transporter-ATP-binding-protein
MIFVENLTKSYDNIKVIDDLSLNVQGGEIFGILGRNGAGKTTFIECMVGLRKRDKGTVKIMNVLTDENQEQIKHIIGVQPQEASLFQRQTVLETLKLFSSFYSQSIDINDLMEELNLKDLEKKLVKSLSKGQKQRLLIAIAMIGDPKILILDEPTSGLDPQVRIMLWEFLKKLKNQGKTILLSTHYMDEAEELCDRVAILHDGKFAAVGTPKELIEKYTVEGKKRNLESAFIHLTGKDLRGGFD
>NZ_AP022557.1|WP_061912243.1|3430251_3431034_+|ABC-transporter-permease
MQIQVHNGKKTILFLVKAGFNEIIRDLKVFFFIIIFPVIFLGIFAGISSVIDKSEQLNISMLEFMFPGILIFALLSTGLFGTALPLVEMRKNGIMRLLTLTPLTTGQFVISQIIVRLILSVVQITLFLILGILLQIITISDVVPLLLVSLIGMVMILSLGFLLGGFMNSVEIAGGILGAISAPILMLSGVMMPFYIMPDIIEDLAIFIPFTYMGDAFRQILFEHLEGKFNIYIDLAAILGFAVLFFVMTKLSFKWTNEKI

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Crispr_ID: NZ_AP022557_32

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_32

3424554-3424647

Orphan

Consensus_repeat	Method
CAGTTCGGCATTTTCACGGAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_32

>merge|NZ_AP022557|32|3424554-3424647|CRISPRCasFinder
CAGTTCGGCATTTTCACGGAAAAGATCCATGGGCAATGGTTTGCCCTCCACCCGGGGATGAAAATCCGCGCCAGTGCGGCATTTTCACGGAAAA

>NZ_AP022557|32|31|3424554-3424647|CRISPRCasFinder
CAGTTCGGCATTTTCACGGAAAA	GATCCATGGGCAATGGTTTGCCCTCCACCCGGGGATGAAAATCCGCGC
CAGTGCGGCATTTTCACGGAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_153017122.1\|3424291_3424477_+\|thiocillin-family-RiPP	unknown	unknown	unknown
NZ_AP022557.1\|WP_153017124.1\|3424090_3424264_+\|thiocillin-family-RiPP	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912365.1\|3415536_3416838_+\|YcaO-like-family-protein	unknown	unknown	gnl\|CDD\|274674
NZ_AP022557.1\|WP_172418757.1\|3414804_3415161_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912243.1\|3430251_3431034_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|130314
NZ_AP022557.1\|WP_061912237.1\|3421629_3423333_+\|SagB-family-peptide-dehydrogenase	unknown	unknown	gnl\|CDD\|188352
NZ_AP022557.1\|WP_061912244.1\|3431048_3431945_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_AP022557.1\|WP_061912239.1\|3424947_3426063_+\|PqqD-family-peptide-modification-chaperone	unknown	unknown	gnl\|CDD\|100080
NZ_AP022557.1\|WP_061912241.1\|3428608_3429502_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372883
NZ_AP022557.1\|WP_061912240.1\|3426077_3428576_+\|lantibiotic-dehydratase	unknown	unknown	gnl\|CDD\|377403
NZ_AP022557.1\|WP_172418841.1\|3435587_3436103_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033842531.1\|3417676_3418813_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_061912238.1\|3423325_3423997_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|376405
NZ_AP022557.1\|WP_015375695.1\|3432433_3433567_-\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NZ_AP022557.1\|WP_172418842.1\|3436305_3437304_+\|protein-rep	unknown	unknown	gnl\|CDD\|366647
NZ_AP022557.1\|WP_033842531.1\|3420038_3421175_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_172418759.1\|3416859_3417597_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200298
NZ_AP022557.1\|WP_172418761.1\|3432174_3432342_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418758.1\|3415167_3415332_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912242.1\|3429515_3430250_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_015375695.1\|3432433_3433567_-\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	1.33314e-25
NZ_AP022557.1\|WP_061912365.1\|3415536_3416838_+\|YcaO-like-family-protein	gnl\|CDD\|274674	TIGR03604, hypothetical_protein, thiazole/oxazole-forming peptide maturase, SagD family component. Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.	1.7998e-102
NZ_AP022557.1\|WP_061912241.1\|3428608_3429502_+\|hypothetical-protein	gnl\|CDD\|372883	pfam14028, Lant_dehydr_C, Lantibiotic biosynthesis dehydratase C-term. Lant_dehydr_C is the C-terminal domain of a family of dehydratases that are involved in the biosynthesis of lantibiotics. While the extensive N-terminal domain, pfam04738, is involved in the serine-threonine glutamylation step of the synthetic process, this C-terminal domain, once thought to be a separate domain from the dehydratase enzymic activity, is necessary for the final glutamate-elimination step in the generation of the lantibiotic. Lantibiotics are a class of peptide antibiotic that contains one or more thioether bonds.	1.11629e-30
NZ_AP022557.1\|WP_061912243.1\|3430251_3431034_+\|ABC-transporter-permease	gnl\|CDD\|130314	TIGR01247, drrB, daunorubicin resistance ABC transporter membrane protein. This model describes daunorubicin resistance ABC transporter, membrane associated protein in bacteria and archaea. The protein associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	3.80447e-11
NZ_AP022557.1\|WP_061912237.1\|3421629_3423333_+\|SagB-family-peptide-dehydrogenase	gnl\|CDD\|188352	TIGR03605, antibiot_sagB, SagB-type dehydrogenase domain. SagB of Sterptococcus pyogenes participates in the maturation of streptolysin S from a ribosomally produced precursor polypeptide. Chemically similar systems operate on highly diverse sets of bacteriocin precursors in numerous other bacteria. This model describes a domain within SgaB and homologous regions from other proteins, many of which appear to be involved in biosynthesis of secondary metabolites. While some substrates may be intermediates in non-ribosomal peptide syntheses, others are involved in heterocycle-containing bacteriocin biosynthesis, and can be found near SgaC-like (see TIGR03603, cyclodehydratase) and SgaD-like (see TIGR03604, "docking") proteins. Members of this domain family are heterogeneous in length, as many have a partial second copy of the domain represented here. The incomplete second domain scores below the cutoffs to this model in most cases.	1.99161e-18
NZ_AP022557.1\|WP_061912244.1\|3431048_3431945_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.09189e-13
NZ_AP022557.1\|WP_061912239.1\|3424947_3426063_+\|PqqD-family-peptide-modification-chaperone	gnl\|CDD\|100080	cd06159, S2P-M50_PDZ_Arch, Uncharacterized Archaeal homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group appears to be limited to Archaeal S2P/M50s homologs with additional putative N-terminal transmembrane spanning regions, relative to the core protein, and either one or two PDZ domains present.	4.82912e-08
NZ_AP022557.1\|WP_061912240.1\|3426077_3428576_+\|lantibiotic-dehydratase	gnl\|CDD\|377403	pfam04738, Lant_dehydr_N, Lantibiotic dehydratase, C-terminus. Lantibiotics are ribosomally synthesized antimicrobial agents derived from ribosomally synthesized peptides. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues. This family constitutes the N-terminus of the enzyme proposed to catalyze the dehydration step, via glutamylation of the substrate during lantibiotic biosynthesis. The enzyme dehydrates Ser/Thr residues in the precursor by glutamylation.	1.1814e-13
NZ_AP022557.1\|WP_033842531.1\|3417676_3418813_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_061912242.1\|3429515_3430250_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	9.85206e-87
NZ_AP022557.1\|WP_172418842.1\|3436305_3437304_+\|protein-rep	gnl\|CDD\|366647	pfam01446, Rep_1, Replication protein. Replication proteins (rep) are involved in plasmid replication. The Rep protein binds to the plasmid DNA and nicks it at the double strand origin (dso) of replication. The 3'-hydroxyl end created is extended by the host DNA replicase, and the 5' end is displaced during synthesis. At the end of one replication round, Rep introduces a second single stranded break at the dso and ligates the ssDNA extremities generating one double-stranded plasmid and one circular ssDNA form. Complementary strand synthesis of the circular ssDNA is usually initiated at the single-stranded origin by the host RNA polymerase.	9.06498e-97
NZ_AP022557.1\|WP_033842531.1\|3420038_3421175_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_172418759.1\|3416859_3417597_+\|hypothetical-protein	gnl\|CDD\|200298	TIGR03603, cyclo_dehy_ocin, thiazole/oxazole-forming peptide maturase, SagC family component. Members of this protein family include enzymes related to SagC, a protein involved in thiazole/oxazole cyclodehydration modifications during biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Recent evidence suggests that the YcaO/SagD-like component, not this component, performs an ATP-dependent cyclodehydration. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins. Note that this model does not find all possible examples of bacteriocin biosynthesis cyclodehydratases, an in particular misses the E. coli plasmid protein McbB of microcin B17 biosynthesis. [Cellular processes, Pathogenesis].	6.07849e-07
NZ_AP022557.1\|WP_061912238.1\|3423325_3423997_+\|nitroreductase-family-protein	gnl\|CDD\|376405	pfam00881, Nitroreductase, Nitroreductase family. The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	2.82218e-06

>NZ_AP022557.1|WP_153017122.1|3424291_3424477_+|thiocillin-family-RiPP
MNREDNNVSFVELELFAEELPEQHNFMASCCWGSIACFTSASTFGSCAATASCSSTASCAC
>NZ_AP022557.1|WP_153017124.1|3424090_3424264_+|thiocillin-family-RiPP
MERMENTTLELYAEELPDITQYTAAGTSTLSTESSVLSASCPTSTVSTYTSMSSYSW
>NZ_AP022557.1|WP_061912238.1|3423325_3423997_+|nitroreductase-family-protein
MTKVIPRSEIVMKLIEDSKEFKKHIVAEGPLVKIFDIGLPNRGRSIEQVFFERTSYRFFHPNSEVDIEDLKTILLKNHQYYIHNWNDDRLVQQYIIGERVNHASINARTIYRYCPDTNDLSAEGYLPENVSKKMLFLQQEFADAPVVLLFVGELAKAVEKIGTAGYKNLLMRAGAVAHYSWLQSMSMGYQGTVFAGVLPKMFKKFCSIDGYRKCQMFAYAFGN
>NZ_AP022557.1|WP_061912237.1|3421629_3423333_+|SagB-family-peptide-dehydrogenase
MKTLNKIDAKEIGMAVSYDPQFRMPIRPKVSKYVNLVSCGDDGVIFDGSPEKQLFRGSAVKKFLYDLISLADGTRTVQEIAETLDTYPSQFIYNALALLYSRGLLQEGTSSHYLEDTPYYKFIERHIDVTRVNLHPTEAIERLHAYSVFIHGKPDDVQYLSNELRQYDISIVDHITPFTEDSKLFAIAICDDINDLMEIKPFASQCYEYSIPWILITFSHKKIYVGPYFERNETLCFECYLKQMNRIDEISIGTNTEMTDPLLKKIGLDYSGIEVVHLLSRIASSHLIHNLKKVDIETFEYTPINVSKLPFCEWCDPIKGMEPTINLVSQYEGYIAFPSSHLINPKDHQNHYKLGNLELAKSSIVYPSCQHINLPHQDSLPDLNSNPRNFSGLQLLTKLMLLTAGLKKNVKNNNPRVYRWAPTGGNLGSVGVYFVNKGVKELQKGVYFYQTSTHTLAQLNGSFEEEVLEKITIDSRLSRGTLLGYLIFSGSYDRVYKKYKEFAYKIIHLDAGVAYAQSQVVAQLLGLELQLCESWNNDEIEHLLRLDHLNEPVTLVATLHRRGESND
>NZ_AP022557.1|WP_033842531.1|3420038_3421175_+|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_033842531.1|3417676_3418813_+|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_172418759.1|3416859_3417597_+|hypothetical-protein
MKIQLFEIGEFANRIGGLLSKRLETDRIKVEDNDFEKLPVRYDADLYVVISEHLCVDLCKYIDNINHNYKKCFLPIVVDHPYLTVGPFVQYGQGACYHCYYERFMQHNPIPHVTRALERHYSEFIGKGPKGYHPLDVAIVSNWLFYSVKNSFNHFQGKDPWAMVCPPPGDENPASVRHFHGKDPWATFCPPPRDENPPFLPIMKNRRKQFNRTLCLMVAWTLYGKVFESTGCTTHCPPFPVIEER
>NZ_AP022557.1|WP_061912365.1|3415536_3416838_+|YcaO-like-family-protein
MNKSIYDLCQPVGGLMTYPQLLPVAHGEPKYYICGSSLGDLSQIENLRYNNHGSQMELTGAGGDISYDMAKFKSLAETLERYCSCVFNEEQFIWATAEELGEDALDLDQIPVCSENELKHPMCPILKPNKKEKIRWVRGISLTSKKLVWVPAIMVYLYIPYKSEGERFWIPISTGCAIHTSYEAALINAINEVIERDAISLTWLHRLPLDKIEIDISLPDWAESYLAKNKEYSYFETYYYNATTDLGIPTIYSVQFSPHNPKLSTVVMCSTELDPLVALTKITREAASVRIALQHKEVKGTDIDTFRDVFEGALYMGSSSMMKEFDFLKYSQGRYPFSKFPNYATNDSKQDLNFLIERLKEKKHEVIAVDLTTDEAAHCGFHAVRVIIPTLQPLSFTYRARYLGTKRLYQAPIDMGYGVRTEEQINPFPQPFA
>NZ_AP022557.1|WP_172418758.1|3415167_3415332_-|hypothetical-protein
MKQNLWDVLQELLEKDVIGATELALAKERLSPQEFSALAAYLQDSSKKEGNLWV
>NZ_AP022557.1|WP_172418757.1|3414804_3415161_-|hypothetical-protein
MNRIEKSAIRTFLQNHLLTNCMLEKEIIQYIFHLLHGKGKIFSTDETHFSWGGGFYAQVSSFHLKDDTCIQSIISHAAAIELLILLSKIYMDKAFRQIATHFPDKQIQIARLKRYLES
>NZ_AP022557.1|WP_061912239.1|3424947_3426063_+|PqqD-family-peptide-modification-chaperone
MDISFKIKESNSNFSLSNPLFLSKDVKMFEVDDETLLFHGQTRKYYKIGKIAKELISQLQTQQSTGEQLVKEISIRFDVKTEEITKNVNEFLKQMIEEGIICTNEGRFDRNKSVHSQRSNKALIKLIKMKNFDRYLSKLSSLLPTMSIKATAVFFILMSVISIVSIISVLRSNYVAPLSGIEFFYLLPWITLHLIGHELSHALVCKKLGGDVREIGFGLLYLVIPVAYVDLTDTYQLKSNKRAFIAVTDPVYDLTMAFISSLFVLYLDGFPKTIAVHFLLIQFMIFCFNCNLLLPSDLYKALENWFKVTNLRNHSLEYLKFTMMNKEKPAYLKGISGIKENFYLLYAILSLFYIASLIFIFVFYYFKIFFD
>NZ_AP022557.1|WP_061912240.1|3426077_3428576_+|lantibiotic-dehydratase
MSGIPTVSNFLLARLAVNSTEILDHMICHQTGNVIREFLRVENELLQLKQPMIDLLYNIVPSLEDQKKLIRFVIKLKRDIFNDRNDRLQKIKEYDYLVLSKYLNEEENIILNTWLRLYKERKGLADKMRQIFNDEKKTIVNWLKEYLKNEESEEFRKGLALASPDLLKILPKGLNDLVHFGSNLSKSIYMYLQRSIIKTSPFSTLTQISTTNFDPLRTVKELDSEFETRHSIRMNRAIVTTVIEELSKHESFNKYFKFQFTTSADAGGKKARITSKYMYTNNFFWKTEETKTLLSSPILSALDQFDEGTEYTLEQILNSLGSNKEYAKYLMFSLKLLRPVVPFDIYEEEPLKKTADLITSNGNGDELVQEVSKHLYRANDLFKELKIGCTGLQRVEKLGKLRIEMKRLFCLLKRNPPQWMEHANLVYEDVRSQIEVPHLGQQVYEDVYKIIEMLRPYFHFSSLYSELLDYFKSTYGPGKEIMLVDFLATLTSNEQLLYRMFERASVRDFQKQKNKTVKGPNIAPPTACIYFQLSAGSQEDLLNGNYLIVVNKISTGLGNVFSRFNPLFKKHPYSGHLKEWIEGLFPLSEPVELSMGGDWSNLQECFGVLTRNIDWFGECKYGSTHYQMKNISISHCQITDSLVLKAQDGNTVSPVYLGTVPQYLIQGSGKILLTLINPWMIDAPYGINPRPWEKIKGVDGIQYIPRQQQGRIVLKRAQWIIPTELLPSFEKSDDDVEVMLKLQRFIDKYQIPTEVFLTMTEKTTSLHGSKPVWIHFHSPYSIEILKRNVTQDTEYIVFTEALPDHRTCWMQNKRGQPIISEFMCLGKLTDHT
>NZ_AP022557.1|WP_061912241.1|3428608_3429502_+|hypothetical-protein
MNQEWIYYNIYPSNSSLMDFVVEDIVRNAYLEVGKITEISKWFFIRYQDHSGTHVRLRFLVSVESLNEVIGILEKLFEEKLTKISRITHYEPKRLIPMKSSQQFNSEQESRFELALYEPEIDKYGGKTGLSISEELFQYSSEICLDVTPGIIDGTLNRFIIGLKYMNESIHAIFERTDTILAFLEKYISYWSGEHYSAIGTTYKNNFIQSAEKRVALTKNIIEQDYHHMNFEKYGKLLKSVIDRINAVNMDKTPEDLLFHYIHMMNNRLGIWPVEEAYLAALLNSFYMNQPMQGAAN
>NZ_AP022557.1|WP_061912242.1|3429515_3430250_+|ABC-transporter-ATP-binding-protein
MIFVENLTKSYDNIKVIDDLSLNVQGGEIFGILGRNGAGKTTFIECMVGLRKRDKGTVKIMNVLTDENQEQIKHIIGVQPQEASLFQRQTVLETLKLFSSFYSQSIDINDLMEELNLKDLEKKLVKSLSKGQKQRLLIAIAMIGDPKILILDEPTSGLDPQVRIMLWEFLKKLKNQGKTILLSTHYMDEAEELCDRVAILHDGKFAAVGTPKELIEKYTVEGKKRNLESAFIHLTGKDLRGGFD
>NZ_AP022557.1|WP_061912243.1|3430251_3431034_+|ABC-transporter-permease
MQIQVHNGKKTILFLVKAGFNEIIRDLKVFFFIIIFPVIFLGIFAGISSVIDKSEQLNISMLEFMFPGILIFALLSTGLFGTALPLVEMRKNGIMRLLTLTPLTTGQFVISQIIVRLILSVVQITLFLILGILLQIITISDVVPLLLVSLIGMVMILSLGFLLGGFMNSVEIAGGILGAISAPILMLSGVMMPFYIMPDIIEDLAIFIPFTYMGDAFRQILFEHLEGKFNIYIDLAAILGFAVLFFVMTKLSFKWTNEKI
>NZ_AP022557.1|WP_061912244.1|3431048_3431945_+|CPBP-family-intramembrane-metalloprotease
MRKSREILVTIGFVVMCIAFTLLSSMMISSISIMIQLESIGDFLSRIGQLLGILSFFIVWYKKITIFEEFALPLYAPKMKRHLWLALSGAILGLLSISVIFLIYIGNDAKYQFNDNGVIHWFAISLLPAIIVHFCVCVSEELLFRGYILSKVEQITTFTVGNAVQSILFSLTHWFNFGFSWKSFVGLVLFGWLMAYLRILSRSLWLPVGFHALWNISQGSIFGFAVSGTAEKNSLIRVHIGGPEWWSGGAFGPEAGIVSMVWLFLLILILGFVLWIQSNKAGVVSSGKSMKGERVEGV
>NZ_AP022557.1|WP_172418761.1|3432174_3432342_+|hypothetical-protein
MNRYQKTAIGLMLVVPLIFLLISLLTDRWGFFLWSLAPSFIVGMTGFFAAKIGIK
>NZ_AP022557.1|WP_015375695.1|3432433_3433567_-|IS4-family-transposase
MNKHTTLPNLMQKLVSDEEIQLIAEAVGYRDSSRTFTLRELIHFFLLAAMHQWKSFRHGADVGPLYGLPRFHYSTVSKKAKEVPYDIMKRLLALIISKCNRQTRRSLRFPKPLRVVDSTTVTVGKNRLPWAPYHGERAGVKLHVAYSPESSLPADVVETIGLRHDGPVGEQLTNAQQVLVEDRAYFKIERLDRFVEQHQLFVIRMKDNIELHQKKSLKRLSSTSSSVQADFTCQLGTKQCRSTKRHRVVIFRDANGRDIRVVTNLFHASAETIADMYQQRWTVEVFFRWVKQYLNVPTLFGTTENAVYNQLFAAFIAYVLLRWLYDQTKKQTNVSLSFISFVRRFFSGQLPLDWKSGMAAALFEYAQIYGRRMYNFG
>NZ_AP022557.1|WP_172418841.1|3435587_3436103_-|hypothetical-protein
MLQQRGGLNENTTQKIINQFPQLKPLLDESNKEVLKTSSTLSELENTFLQLARFFEKPNEEAFSLQLLYQHLEDEWLEFALQLIVEFFRNETYLIKNPNFSIIRDSQDYYTQSDFARYLEDKGIHFPQNKIAVYRKRGKFPKEDLVVAGTPYWSKYTVESFAKHLLEQQKK
>NZ_AP022557.1|WP_172418842.1|3436305_3437304_+|protein-rep
MTDSILVDKTKTGKQRDWQGKKRRSQLTAEHFDKAGLERKAERMNECADTLVFKSTPEGLKLYQAWFCKVRLCPMCNWRRSLKIAYHNKRIVETINEREKVRWVFLTLTVRNTDAESLPETIKAMFKGFQRLTNYKAFKTSVKGYFRALEVTKNRDPESESFGTYHPHFHVLLAVPHTYFKKKDLYITQDEWTSLWQKAMKIDYKPIVHIQRVKPKEKLDDLKGYETQFKKAMKEQNAILEVSKYPVKDTDVIKGNKVTAENVETVLALDNALANKRLIGYGGLLKQIHKELNLGDAENGDLVNVTGEDEVANGTFDVIARWHVGLKNYVIE

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Crispr_ID: NZ_AP022557_33

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_33

3449431-3449529

Orphan

Consensus_repeat	Method
TCCATGGGCGGCGGTCTGTCCTCCACCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_33

>merge|NZ_AP022557|33|3449431-3449529|CRISPRCasFinder
TCCATGGGCGGCGGTCTGTCCTCCACCCAAGCATGAAAATCTCGCGTCAGTCCTGCATTTTTACGGAAAGATCCATGGGCGGCGGTCTGTCCTCCACCC

>NZ_AP022557|33|32|3449431-3449529|CRISPRCasFinder
TCCATGGGCGGCGGTCTGTCCTCCACCC	AAGCATGAAAATCTCGCGTCAGTCCTGCATTTTTACGGAAAGA
TCCATGGGCGGCGGTCTGTCCTCCACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_061912610.1\|3446263_3447187_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_AP022557.1\|WP_172418843.1\|3440673_3441498_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912613.1\|3450768_3452442_+\|lactate-permease-LctP-family-transporter	unknown	unknown	gnl\|CDD\|182445
NZ_AP022557.1\|WP_172418758.1\|3444123_3444288_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912609.1\|3445580_3446264_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|372253
NZ_AP022557.1\|WP_061912616.1\|3458344_3459010_+\|bifunctional-precorrin-2-dehydrogenase/sirohydrochlorin-ferrochelatase	unknown	unknown	gnl\|CDD\|224562
NZ_AP022557.1\|WP_061912619.1\|3461065_3461836_+\|arginase-family-protein	unknown	unknown	gnl\|CDD\|212539
NZ_AP022557.1\|WP_061912614.1\|3455078_3457532_+\|phosphodiesterase	unknown	unknown	gnl\|CDD\|238923
NZ_AP022557.1\|WP_061912611.1\|3448278_3449262_+\|NADPH:quinone-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|176203
NZ_AP022557.1\|WP_153017166.1\|3447874_3448225_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912636.1\|3452692_3453700_-\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237564
NZ_AP022557.1\|WP_073519239.1\|3441508_3441874_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912637.1\|3454278_3454731_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_AP022557.1\|WP_061912618.1\|3460557_3460905_-\|YojF-family-protein	unknown	unknown	gnl\|CDD\|378061
NZ_AP022557.1\|WP_051962763.1\|3447577_3447811_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_061912617.1\|3459891_3460545_-\|bacillithiol-biosynthesis-deacetylase-BshB2	unknown	unknown	gnl\|CDD\|188515
NZ_AP022557.1\|WP_172418763.1\|3439844_3440285_-\|DNA-repair-protein-RadC	unknown	unknown	gnl\|CDD\|178801
NZ_AP022557.1\|WP_061912612.1\|3449577_3450303_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_AP022557.1\|WP_061912615.1\|3457533_3457905_+\|DUF1992-domain-containing-protein	unknown	unknown	gnl\|CDD\|182303
NZ_AP022557.1\|WP_033020624.1\|3444872_3445466_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_061912610.1\|3446263_3447187_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.62927e-90
NZ_AP022557.1\|WP_061912636.1\|3452692_3453700_-\|rod-shape-determining-protein	gnl\|CDD\|237564	PRK13930, PRK13930, rod shape-determining protein MreB; Provisional.	2.58807e-162
NZ_AP022557.1\|WP_061912613.1\|3450768_3452442_+\|lactate-permease-LctP-family-transporter	gnl\|CDD\|182445	PRK10420, PRK10420, L-lactate permease; Provisional.	0
NZ_AP022557.1\|WP_172418763.1\|3439844_3440285_-\|DNA-repair-protein-RadC	gnl\|CDD\|178801	PRK00024, PRK00024, DNA repair protein RadC.	4.11481e-56
NZ_AP022557.1\|WP_061912619.1\|3461065_3461836_+\|arginase-family-protein	gnl\|CDD\|212539	cd11593, Agmatinase-like_2, Agmatinase and related proteins. This family includes known and predicted bacterial and archaeal agmatinase (agmatine ureohydrolase; AUH; SpeB; EC=3.5.3.11), a binuclear manganese metalloenzyme that belongs to the ureohydrolase superfamily. It is a key enzyme in the synthesis of polyamine putrescine; it catalyzes hydrolysis of agmatine to yield urea and putrescine, the precursor for biosynthesis of higher polyamines, spermidine, and spermine. As compared to E. coli where two paths to putrescine exist, via decarboxylation of an amino acid, ornithine or arginine, a single path is found in Bacillus subtilis, where polyamine synthesis starts with agmatine; the speE and speB encode spermidine synthase and agmatinase, respectively. The level of agmatinase synthesis is very low, allowing strict control on the synthesis of putrescine and therefore, of all polyamines, consistent with polyamine levels in the cell. This subfamily belongs to the ureohydrolase superfamily, which includes arginase, agmatinase, proclavaminate amidinohydrolase, and formiminoglutamase.	9.91069e-10
NZ_AP022557.1\|WP_061912614.1\|3455078_3457532_+\|phosphodiesterase	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.49599e-114
NZ_AP022557.1\|WP_061912611.1\|3448278_3449262_+\|NADPH:quinone-oxidoreductase-family-protein	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.51632e-94
NZ_AP022557.1\|WP_061912637.1\|3454278_3454731_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.6621e-42
NZ_AP022557.1\|WP_061912617.1\|3459891_3460545_-\|bacillithiol-biosynthesis-deacetylase-BshB2	gnl\|CDD\|188515	TIGR04000, thiol_BshB2, bacillithiol biosynthesis deacetylase BshB2. Members of this protein family are BshB2 (YojG), an enzyme of bacillithiol biosynthesis; either BshB1 (YpjG) or BshB2 must be present, and often both are present. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	9.23379e-142
NZ_AP022557.1\|WP_061912618.1\|3460557_3460905_-\|YojF-family-protein	gnl\|CDD\|378061	pfam08830, DUF1806, Protein of unknown function (DUF1806). This is a bacterial family of uncharacterized proteins. The structure of one of the proteins in this family has been solved and it adopts a beta barrel-like structure.	1.96438e-73
NZ_AP022557.1\|WP_061912609.1\|3445580_3446264_+\|ABC-transporter-permease-subunit	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	0.000208934
NZ_AP022557.1\|WP_061912612.1\|3449577_3450303_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	1.042e-68
NZ_AP022557.1\|WP_061912615.1\|3457533_3457905_+\|DUF1992-domain-containing-protein	gnl\|CDD\|182303	PRK10203, PRK10203, hypothetical protein; Provisional.	3.71136e-28
NZ_AP022557.1\|WP_061912616.1\|3458344_3459010_+\|bifunctional-precorrin-2-dehydrogenase/sirohydrochlorin-ferrochelatase	gnl\|CDD\|224562	COG1648, CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism].	2.9222e-59

>NZ_AP022557.1|WP_061912611.1|3448278_3449262_+|NADPH:quinone-oxidoreductase-family-protein
MKAVVIEEFGGVEVLKLKDIEEPKPKPNEVIIAVSKTSLNFADIKNRTGKKAKGEFPLILGLDAAGIVVEVGEQVKSISVGQRVIAFPSNGSYTEYVVADEKLVFPIPDNMDMLTAAACPIVSFLSYALLKYLARIQEGESVLIHSASGGVGTTAIQLARIFGAKQIFGSVGNIEKAFIAIDAGADEVFTYENFVREVKERTDGQGVNVILDSVGGTVSEQSMNCLANYGRLIHFGNSSGKPGTFLTNQVHASCRSVLGFSLGTTRKERPEYLKHIADSVIRLISKGDLRIKIGHVFELSEISNAHALMENRMHSGKIIINVNDSIK
>NZ_AP022557.1|WP_153017166.1|3447874_3448225_+|hypothetical-protein
MHCRMNPLHPREPKSSNSSIKGTGKAKFSTNNLPKDPEELINKGWKDVTPEGMATSSRELIDSEIGMKVRFDPRKLYICSLKNEHLASPATSFLSRGLRIFGRNDTALRVYRITER
>NZ_AP022557.1|WP_051962763.1|3447577_3447811_+|hypothetical-protein
MNNFIEKGFMYGFVIGITLALIFVPYKTVTYMTGGVTATEYKEIPEYIINVLRVSFSSGVVASIIGLALYKKRRTKD
>NZ_AP022557.1|WP_061912610.1|3446263_3447187_+|ABC-transporter-ATP-binding-protein
MKMIQVHNLKKKFKDHYVVKGVTFDVEKGEIFGFLGKNGAGKTTTINMLTGITLPSEGSFVIGGKTNKEMNEIKKMIGVMPDAANYYYDFTALEHLTFFAKLKNVKLKKVDALTILDSVGLKGHEKKKVGSYSFGMKKKLGIAQAIIGTPSVVFLDEPTSGLDPESAAEIQQLIQQLASNDMTIFLTSHNLSEVEKICDTIAIMEDGVISKIGTMEQLRGMYKRAIQLLIKIKKDEQHSIVHLLKRDVGDFISNVQTSGDYLCCELWRESDIPKLIHYLSGQNIDIYEARVEKATLEDIFFDRAADR
>NZ_AP022557.1|WP_061912609.1|3445580_3446264_+|ABC-transporter-permease-subunit
MRAIIEKEFKSLFKSFKSIAVILFFLIVSFAASKFFSNNLELLQQDQGESVYVSSIRALVMFFGFLFVLSLSHDVINREVENQTIRFLVTKSSRNAIVIGKFLGIFLFWFVCVLSSFTVIALFARQLFVFDFLKMISFLAYAIGVTILLSLVVKKPSHTTFIAILLGIAIPVLGIWSIASKQFVLKIVKYVLPYYYIMKGSYYTFVPACFAALMLLIALAVFKRRDL
>NZ_AP022557.1|WP_033020624.1|3444872_3445466_+|hypothetical-protein
MNKRKSVKNLVGIVFFIVVFVFVCMISFGDLYLTPLDAAKKNNYIHKNAILLKEISARENKIYIFRDNDQSYKTVISKPFGPLWKSEIAFNYQSNLKNDIETVGYAKINDQTINILMLAFKTNTNKIKYVEAGPDGERFLRPMHLGNIEIFYWEGKFNERDINPIALSSDKKPKYYYGFSKDEQYDDLRTIQWHEYH
>NZ_AP022557.1|WP_172418758.1|3444123_3444288_-|hypothetical-protein
MKQNLWDVLQELLEKDVIGATELALAKERLSPQEFSALAAYLQDSSKKEGNLWV
>NZ_AP022557.1|WP_073519239.1|3441508_3441874_-|hypothetical-protein
MMNMEKTKPFCKMTPDEYYDFLWSYTTFDKTREQLIEDLEITEEEEKYLDEALNYLKSRVEIHEKEGRPNPSYAFYLVEYLEEAVDEGVPEETVREIEKALDENDEEKLADAVKKAWGIRE
>NZ_AP022557.1|WP_172418843.1|3440673_3441498_-|hypothetical-protein
MSIRTGDIVLVRDYPNLQYKEAHAAPTKTRFAVVIGNFRGGYATLPAHAIVTKGGKTEQPYYRLKENELRVPANIISDRSDIALKGVIKAHRFPLIGKEQMILKVGSLPLETKIQLIDIHEMIRNRPIHVLEMEKENPYYAKFMGFFKEVTLAEKMQFMRDDRGNHQYEFVRNEEFRVKAIQLLEKRNHLHILSVQLEGDKGTFTHTFATKKSLQEIREDWKEPKKAKEWIREDVKFYALWKNPFLQLKPDPQPHPDKYQPLEKFREKSSVLER
>NZ_AP022557.1|WP_172418763.1|3439844_3440285_-|DNA-repair-protein-RadC
MEKIYEIQRIKQIVQEVEERYKIRCPEDAAKVAAHFIGDDDREVFFVMCLNTKNEVVAVHRCHIGSLNSSIVHPREVFKAAILNNSASIIVAHQHPSGDVTPSREDVEMTKRLAEAGRILGIEILDHLVINYKAEYTSLKEKGFFS
>NZ_AP022557.1|WP_061912612.1|3449577_3450303_-|FadR-family-transcriptional-regulator
MAFKRIKTKKIYEEVAEAIFDMIKNGELKPGDKLDSVQQLAEQFQVGRAAIREALTALKAMGLIELKHGEGTYVREFDPTVMTFPLSIAVLMNKEDIWHLLEVRKLLEAGAASLAAAKRTDRDLDAMTEALRQMKEGIGSDELGEKADLAFHMAIAAASQNPMLMSIMNSVSGMIVETMRETRRIWLFSKQTTTEKLLAEHQAIFEAIRDQNPDAARARMLEHLTNVENVLRRYIRTQQPD
>NZ_AP022557.1|WP_061912613.1|3450768_3452442_+|lactate-permease-LctP-family-transporter
MWKQDFTPIADQLWLSAIVALIPILYFFWALAVKRMKGHVAGLTTLLLAVVLAVIAYRMPAGKAVMSVTQGAVYGLLPIGWIIITSVFLYKLTVKTGHFDIIRNSVISLTEDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLAGLGFNPLYAAGLCLIANTAPVAFGAVGIPIISMEGPTGVPAMEISKMVGRQLPFLSVFIPFYLVLIMAGWKKIVEVLPAIIVSGVSFALTQYLSSNFLGPELPDILSSLVSIVALAVFLHYWKPKSIFRFATESEVAAAGQAVRTTHSSGEVFRAWSPFLVLTALISLWGIPQVKAALTGHYEGTNGLLKAVNAIGSHLTFMPPVPGLNNQILNASGQPIAAVYKLELLGAAGTAILLAAVVSKFIVGISWKEWARTFAETLNELKYPLITIASVVGFAYIANSSGMSTTLGMALAKTGSFFPFFSPILGWLGVFITGSDTSSNLLFGNLQKVTATSIGMDPVLALAANSSGGVVGKMISPQSIAVACAAVGLTGKESDLFRFTVKHSVFLIILIGILVYLQSTVLSWMIP
>NZ_AP022557.1|WP_061912636.1|3452692_3453700_-|rod-shape-determining-protein
MFVSSELGIDLGTMNVRLFSQTKGLIFDEPAAVAYHRQADKLIAIGQRAKTMIGKAPAHVEVTYPLQHGVIADFERAKTLLQEVFKQSSRQLGLSFKKPNVVMSVPFHATSVERRSFYEIAKHCGAKHIHLIEEPVAAAIGADLPVGEPVANVIVHLGAGKTEAAIISFGGVVACRSLRIGGNQLDEDIMQYVRQRYNLLIGEQTAEQVKIEIGSAPGTSLTQGMTIHGRDVVTGFLKAISLDPAEVQHALKESLLQIAEAIRAVLEECPAELSGDIIDRGIVLTGGGALLRGMEQWLGAMLHVPVYVAPNPAEAVAIGTGKALRAMPKQLGAAL
>NZ_AP022557.1|WP_061912637.1|3454278_3454731_-|C40-family-peptidase
MKKWLTFLSVSITFLFSSFFVNTSNIDAAANKTRLIAEAKKLLGTPYRYGGTTPKGFDCSGFVYYTHKKVGVILPRSSKAMYQKGTYVHRSKLQPGDLVFFNTSKGGKGVSHVAIYIGNNQVIHAVSRGVKIDNLNSPYWKPKYMGAKRL
>NZ_AP022557.1|WP_061912614.1|3455078_3457532_+|phosphodiesterase
MSNHIEYAFYVFGWLLITGVVYIYGHWMAKRHWKRMPWRAAPKLTTGFAMVSLLFLGAGEGYIHYMEQHEHREYEENAKQVAAMVAGDLAAMGHERLDEHADRLPVYDGIIAALERWQSRGRVLSIYTMKKNKNGQLYFVVAPPTDYNRNGRIDSDKEQAVSPGTIYRYDVPEIDKAFGGHFAMQPRPTTDKWGRSISAFMPVRRADGTVDAVVGIDYDAAIYEHRLQKERQKAMGMMMAVYFIAAAIYLLALHQQMERKAFAAYKKRLAANEHRLRRLAEMTMEGIIVYANGRIIEVNEAACRLLGYAESELIHLPIDELIVHGSIKFSQPHEERERLEMDLRRKDGTVFPAEIVRRRYDYEGENVTVAAVRDLTEQKQKEQRIRYIANHDELTGLPNKEAMYKTVERCLAQAKRNGQEAAIIFFEVSGIKTINDFYGYAVGDEVLLYLAQVWKEKAGMIIGRWSGNEFLAVVPDSSLEKAEEMAKQLVEVADEPIIVNGIELYITVNAGISIYPKDGEEAKTLIRKADIARYEVRKKAVSDFVFFTEPMANRLHENMAMERDLRRALERDEFELYYQPQIRLHDRSVIGMEALIRWRHPEKGMIPPSLFIPLAEQTGMIIPINEWVMRTACRQTKQLLSQFPHLSVSVNLSPYEFESRRFVDKLARLLDEIGLPPHHLDLEITERMTMDTERALDILPKLKALGVTISMDDFGTGYSSLSYLTDLPIDRLKIDRSFVQHIQGKKDVILPAIIRLGHNIGVKVLAEGVETETEAAYLQGKRCDEAQGYYFSPPLPYEELVRFLTEQHARRQTQELT
>NZ_AP022557.1|WP_061912615.1|3457533_3457905_+|DUF1992-domain-containing-protein
MDGFWRIAEEKIREAMDNGEFDHLPGFGKPLELEDISHIPEELRLGYLLLKNAGYVTEETKLRKELMTLEDLLRCCEDDEKKQELTKKWTEKQLRFAELMKKRQPTNTKALRDYGRRIEEKFR
>NZ_AP022557.1|WP_061912616.1|3458344_3459010_+|bifunctional-precorrin-2-dehydrogenase/sirohydrochlorin-ferrochelatase
MGYPVMLQVRGRRAVVVGGGKVAARKIRGLLAAGADVVMIAPKAEPELQALAAAGMIGWRVKTFAPHDLDGAFLVIAATNDREVNEAVAQAAASGQLLNIVDAPEQCDFHVPAVIRRGPLTIAVSTEGASPAVARRIRRELEERYGEEYGAYLEFLQRARAIVLREVADAEGRKRLFRALAADSFRQNGRWDEELAGLLAKEKERSGEREDRNDEDPNVHC
>NZ_AP022557.1|WP_061912617.1|3459891_3460545_-|bacillithiol-biosynthesis-deacetylase-BshB2
MNERHVLVVFPHPDDEAFGVSGTIAQHAQSGTPVTYACLTLGEMGRNMGVPPFANRETLPFIRRHELEEACRVLGIHDLRLLGYRDKTIEFEDEEELADRIAAIVAETNPSLVITFYPGYSVHPDHDACGEAVIRALKRWPKEQRPTVYCVAFAKNCEQELGQPDIIRDVSSVIDTKLAAIRAHRSQTEGLMQAAATRGDALAWLKTERFWTYRWDD
>NZ_AP022557.1|WP_061912618.1|3460557_3460905_-|YojF-family-protein
MQPIDAAVVQEALNRLANRDVYIHLETTNGAYAAHHNEGFFSAGAFIRNARIRFTRGKITGLGPYRIGLKLDIGWVYAEGLTHWEWTKEEQLLLAGHDYEGKLAVALELSGKPFA
>NZ_AP022557.1|WP_061912619.1|3461065_3461836_+|arginase-family-protein
MGFQGNGVALLHLDGTYRPQTRLLRFPHEWVDLADVPETNLYCSQTALAEIERRLRRRRTRGAVLIGSGNYHYVTYLLLQEIQEPFTLVLFDHHTDADPSDGFLMSCGSWVARALDHPQLRKVVIAGPTFSPNHLQLSPNITVLSFADDDEWPRALLEVVPTRSVYISIDKDALSREDAVTNWDHGTMPLSVLLACLRRLLLQKNVLGVDVCGEYPRSAVDAFDPLCREAQRKNEQANMAILETCFRYATPHLRPA

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Crispr_ID: NZ_AP022557_34

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_34

3471239-3471333

Orphan

Consensus_repeat	Method
TTTTCCGTGAAAATGCCGAACTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_34

>merge|NZ_AP022557|34|3471239-3471333|CRISPRCasFinder
TTTTCCGTGAAAATGCCGAACTGTCGCGAGATTTTCATGTCTGGGTGGAGGGCCGATCACCGCCCATGGATCTTTTCCGTGAAAATGCCGCACTG

>NZ_AP022557|34|33|3471239-3471333|CRISPRCasFinder
TTTTCCGTGAAAATGCCGAACTG	TCGCGAGATTTTCATGTCTGGGTGGAGGGCCGATCACCGCCCATGGATC
TTTTCCGTGAAAATGCCGCACTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_061912627.1\|3470030_3471164_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341030
NZ_AP022557.1\|WP_172418768.1\|3476827_3477619_+\|delta-lactam-biosynthetic-de-N-acetylase	unknown	unknown	gnl\|CDD\|131930
NZ_AP022557.1\|WP_172418772.1\|3481814_3482960_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341138
NZ_AP022557.1\|WP_172418770.1\|3478725_3480132_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|129571
NZ_AP022557.1\|WP_172418767.1\|3475110_3476658_+\|fumarate-hydratase	unknown	unknown	gnl\|CDD\|377546
NZ_AP022557.1\|WP_172418773.1\|3483003_3486345_+\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|226581
NZ_AP022557.1\|WP_172418771.1\|3480348_3481806_+\|SAM-dependent-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|223363
NZ_AP022557.1\|WP_061912622.1\|3464605_3465217_-\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|179661
NZ_AP022557.1\|WP_061912625.1\|3468097_3468580_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NZ_AP022557.1\|WP_061912621.1\|3463679_3464456_-\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|235711
NZ_AP022557.1\|WP_172418764.1\|3471607_3472660_+\|calcium/proton-exchanger	unknown	unknown	gnl\|CDD\|273043
NZ_AP022557.1\|WP_061912620.1\|3462921_3463668_-\|sirohydrochlorin-chelatase	unknown	unknown	gnl\|CDD\|225049
NZ_AP022557.1\|WP_172418765.1\|3472881_3473670_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372941
NZ_AP022557.1\|WP_061912626.1\|3468684_3469518_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NZ_AP022557.1\|WP_061912624.1\|3467655_3467880_-\|DUF1128-domain-containing-protein	unknown	unknown	gnl\|CDD\|377674
NZ_AP022557.1\|WP_061912623.1\|3465229_3466390_-\|sulfate-adenylyltransferase	unknown	unknown	gnl\|CDD\|235227
NZ_AP022557.1\|WP_033020583.1\|3469760_3469907_-\|BH0509-family-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418766.1\|3473757_3474885_-\|radical-SAM/CxCxxxxC-motif-protein-YfkAB	unknown	unknown	gnl\|CDD\|275271
NZ_AP022557.1\|WP_172418769.1\|3477862_3478729_+\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NZ_AP022557.1\|WP_033020587.1\|3466503_3467211_-\|phosphoadenylyl-sulfate-reductase	unknown	unknown	gnl\|CDD\|129526

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_061912627.1\|3470030_3471164_-\|MFS-transporter	gnl\|CDD\|341030	cd17477, MFS_YcaD_like, YcaD and similar transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.3012e-78
NZ_AP022557.1\|WP_172418768.1\|3476827_3477619_+\|delta-lactam-biosynthetic-de-N-acetylase	gnl\|CDD\|131930	TIGR02884, spore_pdaA, delta-lactam-biosynthetic de-N-acetylase. Muramic delta-lactam is an unusual constituent of peptidoglycan, found only in bacterial spores in the peptidoglycan wall, or spore cortex. The proteins in this family are PdaA (yfjS), a member of a larger family of polysaccharide deacetylases, and are specificially involved in delta-lactam biosynthesis. PdaA acts immediately after CwlD, an N-acetylmuramoyl-L-alanine amidase and performs a de-N-acetylation. PdaA may also perform the following transpeptidation for lactam ring formation, as heterologous expression in E. coli of CwlD and PdaA together is sufficient for delta-lactam production. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination].	3.96676e-153
NZ_AP022557.1\|WP_172418772.1\|3481814_3482960_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341138	cd17249, RMtype1_S_EcoR124I-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.EcoR124I TRD2-CR2, S.Eco540I TRD2-CR2, S.Eco540AI TRD2-CR2, and S.Eco540ANI TRD2-CR2. Escherichia coli (R124) S subunit (S.EcoR124I), E. coli ST540 S subunit (S.Eco540I), E. coli ST540A S subunit (S.Eco540AI), and Escherichia coli ST540AN S subunit (S.Eco540ANI) recognize the sequence 5'... GAANNNNNNRTCG ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, S.EcoR124I -TRD1 recognizes GAA/TTC, and -TRD2 recognizes CGAY/RTCG. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	1.0645e-81
NZ_AP022557.1\|WP_172418770.1\|3478725_3480132_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|129571	TIGR00479, 23S_rRNA_uracil1939-C5-methyltransferase_RlmD, 23S rRNA (uracil-5-)-methyltransferase RumA. This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification].	0
NZ_AP022557.1\|WP_172418767.1\|3475110_3476658_+\|fumarate-hydratase	gnl\|CDD\|377546	pfam05681, Fumerase, Fumarate hydratase (Fumerase). This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre.	2.19433e-101
NZ_AP022557.1\|WP_172418773.1\|3483003_3486345_+\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|226581	COG4096, HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	0
NZ_AP022557.1\|WP_172418771.1\|3480348_3481806_+\|SAM-dependent-DNA-methyltransferase	gnl\|CDD\|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	7.25061e-75
NZ_AP022557.1\|WP_061912622.1\|3464605_3465217_-\|adenylyl-sulfate-kinase	gnl\|CDD\|179661	PRK03846, PRK03846, adenylylsulfate kinase; Provisional.	5.44039e-126
NZ_AP022557.1\|WP_061912625.1\|3468097_3468580_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	2.71961e-75
NZ_AP022557.1\|WP_061912621.1\|3463679_3464456_-\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|235711	PRK06136, PRK06136, uroporphyrinogen-III C-methyltransferase.	5.06147e-148
NZ_AP022557.1\|WP_172418764.1\|3471607_3472660_+\|calcium/proton-exchanger	gnl\|CDD\|273043	TIGR00378, cax, calcium/proton exchanger (cax). [Transport and binding proteins, Cations and iron carrying compounds].	1.96152e-139
NZ_AP022557.1\|WP_061912620.1\|3462921_3463668_-\|sirohydrochlorin-chelatase	gnl\|CDD\|225049	COG2138, COG2138, Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism].	2.71652e-52
NZ_AP022557.1\|WP_172418765.1\|3472881_3473670_+\|hypothetical-protein	gnl\|CDD\|372941	pfam14167, YfkD, YfkD-like protein. The YfkD-like protein family includes the B. subtilis YfkD protein, which is functionally uncharacterized. Its expression is regulated by the sigma factor sigma-B, which regulates the expression of stress-response proteins, and by the forespore-specific sigma factor sigma-G. This family of proteins is found in bacteria. Proteins in this family are typically between 254 and 265 amino acids in length.	3.7623e-148
NZ_AP022557.1\|WP_061912626.1\|3468684_3469518_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	1.10786e-67
NZ_AP022557.1\|WP_061912624.1\|3467655_3467880_-\|DUF1128-domain-containing-protein	gnl\|CDD\|377674	pfam06569, DUF1128, Protein of unknown function (DUF1128). This family consists of several short, hypothetical bacterial proteins of unknown function.	1.18227e-29
NZ_AP022557.1\|WP_061912623.1\|3465229_3466390_-\|sulfate-adenylyltransferase	gnl\|CDD\|235227	PRK04149, sat, sulfate adenylyltransferase; Reviewed.	0
NZ_AP022557.1\|WP_172418766.1\|3473757_3474885_-\|radical-SAM/CxCxxxxC-motif-protein-YfkAB	gnl\|CDD\|275271	TIGR04478, radical_SAM_superfamily_domain_protein, radical SAM/CxCxxxxC motif protein YfkAB. Members of this highly conserved family in some Firmicutes have an N-terminal radical SAM domain (pfam04055) and a C-terminal pfam08756 domain with a CxCxxxxC motif that suggests binding to an additional metallocluster. It appears all correct sequences in this family are about 370 amino acids in length, containing the YfkA and YfkB regions originally reported as separate ORFs in Bacillus subtilis. Partial Phylogenetic Profiling shows occurrences almost exclusively in the Bacilli, with very few examples of either lateral transfer or gene loss. The essentially monophyletic distribution suggests a housekeeping function. Members have no well-conserved gene neighborhood. The function is unknown. [Unknown function, Enzymes of unknown specificity].	0
NZ_AP022557.1\|WP_172418769.1\|3477862_3478729_+\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	2.14728e-68
NZ_AP022557.1\|WP_033020587.1\|3466503_3467211_-\|phosphoadenylyl-sulfate-reductase	gnl\|CDD\|129526	TIGR00434, Phosphoadenosine_phosphosulfate_reductase, phosophoadenylyl-sulfate reductase (thioredoxin). This enzyme, involved in the assimilation of inorganic sulfate, is designated cysH in Bacteria and MET16 in Saccharomyces cerevisiae. Synonyms include phosphoadenosine phosphosulfate reductase, PAPS reductase, and PAPS reductase, thioredoxin-dependent. In a reaction requiring reduced thioredoxin and NADPH, it converts 3(prime)-phosphoadenylylsulfate (PAPS) to sulfite and adenosine 3(prime),5(prime) diphosphate (PAP). A related family of plant enzymes, scoring below the trusted cutoff, differs in having a thioredoxin-like C-terminal domain, not requiring thioredoxin, and in having a preference for 5(prime)-adenylylsulfate (APS) over PAPS. [Central intermediary metabolism, Sulfur metabolism].	1.67044e-112

>NZ_AP022557.1|WP_061912627.1|3470030_3471164_-|MFS-transporter
MRFAVLTGIVAISGLSQGMLLPLLALLLDKQGISSSVNGGHAAALYAGVLLISPFLEQPLGKYGYKPMILLGSSIVICSLTLFPLFPSFFIWFVLRFLIGVGDHMLHFATQTWITDFSPPEKRGRRLSLYGLAFGLGFTVGPLLASLASVNEALPFFIGALLSLIGWVAVFSLPNEKPRPLERTSTAAGRWLGAWKGAWPALLLPFAYGFLEAAIHSVFPLYALDQRLSTEQIAFLLPCFSLGGILFQLPLGALSDWLGRRITITGALLAGAGCFLAAFAAGPSPVSLAICLFAAGMFTGSLFSLGIAYMTDLLPKALLPAGNLLCGMLYSLGSMIGPPLSGSAVDVAADAFFLAVSAVLLLPVLGLVKRRKQEKTA
>NZ_AP022557.1|WP_033020583.1|3469760_3469907_-|BH0509-family-protein
MSRTERKNMIEFIEKVRGLSREQLACMTDAEIEYLYERSYHHHEEIVE
>NZ_AP022557.1|WP_061912626.1|3468684_3469518_+|YihY/virulence-factor-BrkB-family-protein
MLVNATFIRELARRFQEDEIPRLSAELAYYFLLSLFPFLLFLMTLLAYLPIPHEDVLALVRQYAPKEALRLIETNVHRLMDEQNGGLLSFSIIAAVWSASNGMSAIMRAFNRAYDVQEDRPFWVVRGLSIVLTLGMIAVIIVALVLPVFGRMIGLFLFSALGLSRPFLDVWNTLRWVTSSLLLFAVFTALYYFAPNKRLRCVNVVRGAVFATAGWIATSSAFSYYVNNFANYTAMYGSLGGMIVLMVWFYLSGMILILGGELNALFDCEREGRKRVR
>NZ_AP022557.1|WP_061912625.1|3468097_3468580_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MVKVLFVCLGNICRSPMAEAVFRHLVKERGLEHVITVDSAGTGSWHVGEPPHAGTRRILSENKIDYSGIRARQVARRDLEEFDYIIAMDATNLNDLRRLAGPRSRAVIARLLDFVPERETDDVPDPYYTGNFAEVYRLIRAGCEHLLETIMRDHRLTEEH
>NZ_AP022557.1|WP_061912624.1|3467655_3467880_-|DUF1128-domain-containing-protein
MDLSKPSAENVEYMIDQLKQKLKMLNWEAMKPSHFSEEWYDELKEIFEMVMKREAFSPSEMQAIVEELGNLRKK
>NZ_AP022557.1|WP_033020587.1|3466503_3467211_-|phosphoadenylyl-sulfate-reductase
MLTYDQWETAEKPSFPSDNETKGALDVLAWAYREYGDEMVYACSFGIEGIVLIDLISQVKPDAEIVFLDTGLHFQETYDTIEKVKEKYPSLRIVMKRPSLTLEQQAAQFGDELWKRDPNKCCELRKVIPLREALTGVTAWISGLRREQSPTRRHVEYINKDDKFRSVKVCPLIHWTWKDVWNYVYKHDLPYNVLHDRGYPSIGCAPCTAPAVDPNDLRSGRWAGQGKTECGLHLT
>NZ_AP022557.1|WP_061912623.1|3465229_3466390_-|sulfate-adenylyltransferase
MSVSIPHGGTLINRWNPDYPLDEASKTIELSKAELSDLELIGTGAYSPLTGFLTKADYDAVVDTMRLADGTVWSIPITLAVTEEKAKELAVGDKAKLVYNGDVYGVIEIADMYRPDKTKEATFVYKTDELAHPGVRKLFEKPDVYVGGEVTLVKRTDKGPFAAFYFDPAETRKRFAELGWNTVVGFQTRNPVHRAHEYIQKCALEIVDGLFLNPLVGETKADDIPADIRMESYQVLLENYYPKDRVFLGVFQAAMRYAGPREAIFHAMVRKNFGCTHFIVGRDHAGVGNYYGTYDAQKIFSNFTAEELGITPLFFEHSFYCTKCEGMASTKTCPHDAEHHVVLSGTKVREMLRNGQVPPSTFSRPEVAAVLIKGLQQREAVTPSTR
>NZ_AP022557.1|WP_061912622.1|3464605_3465217_-|adenylyl-sulfate-kinase
MSTNIVWHQTSVTKQDRRERNSHHSAILWFTGLSGSGKSTVANAVSRRLFELGIQNYVLDGDNIRHGLNKDLGFSAADRTENIRRIGEVAKLFVDSGQFVLTAFISPFAEDRALVRRLVDEDEFIEIYVSCPLEECEKRDPKGLYEKARRGEIREFTGIDSPYEAPTAPELTIETDRYSVEECVEQVLAYLRERRMIPAAKAD
>NZ_AP022557.1|WP_061912621.1|3463679_3464456_-|uroporphyrinogen-III-C-methyltransferase
MGKVYLVGAGPGDPELITVKGLTCIQRADVILYDRLINEELLSYAKPDAELIFCGKLPGCHAMQQETINRALVLHAKKGKTVVRLKGGDPFVFGRGGEEAEALVKHGIEFEIVPGVTSAIAAAAYAGIPVTHREFSSSVAFVTGHRREGSGDEIQWESLAKGIDTIAIYMGIQRLSSICGQLMKYGKSPETPAAVIEWGTTSAQRTVTGTLATIAEIAANEQMRNPSMVIIGEVVRLRANIQWYERLLWSSAAAGATS
>NZ_AP022557.1|WP_061912620.1|3462921_3463668_-|sirohydrochlorin-chelatase
MEAVLYVSHGSRVAAARLEATRFFEQCKAAVDIPIQELCFIELAEPDIITGVDRCVAQGATRIIVIPLLLLSAGHAKRDIPAALELAKQRHPAVEIVCGSPFGVHDAMIDIIIDRISECASSLDGESMILLIGRGSSDPDTKRDITAIARRLQEKTHVPHVSVCFLAAIGPTLDEGLEQANASPCRRVFVVPYLLFTGVLMKTIERKLRGFPTSDKQWHLCPYLGYHPRLVTLIRQQVASLALAKKGA
>NZ_AP022557.1|WP_172418764.1|3471607_3472660_+|calcium/proton-exchanger
MNKVFAWLTWIGVPVSVIGGLLHWPTVLLFGLYCLTIIALASYMGRATESLAIVAGPRIGGLLNATFGNAVELIISIFALKAGLVDVVLASLTGSVLGNLLLVAGLSFFVGGLKYKRQGFNIYDARHNAGLLTFAIFVAFVIPEVFTMQMDRGEQLALSVGIAIIMILLYIAALYFRLVTHRGVYQHQSDKTEEHEEPEWGKGKATTILALATVAVAYLSERLVHTFETVAESFGWSELFIGIIIVAIVGNAAEHASAVIMAYKNKMNVAVEIAVGSTLQIAMFVAPVLVLVSLLFPEKMPLVFSLPELVAMAASVLLIIVLSNDGDTNWFEGATLLAAYTIMGIGFYLL
>NZ_AP022557.1|WP_172418765.1|3472881_3473670_+|hypothetical-protein
MKKWSVSLLVSALLLYAAAAPTLASSGKPAPNAVIDISKENTYPNPTQDLPHLEPSSFAKQLLKSANVKIENPELIHLLNESSATDTPWAIGYRATIYLGQWPLNYHSLETSTNWEYQKVNMNFLDNRGGDAAQKLYYKQEMQKHVRGGLTSKVPNEDAVKRMMLNKAMEKTNLPLAFSTVVGLGTKKDQPYQVPAKKMGYLYAYVPAVNEKGKVTYGEVYVVLRGNKKNIVVKNVTTRGVGAWIPVQDRLYMSYAVSEQPR
>NZ_AP022557.1|WP_172418766.1|3473757_3474885_-|radical-SAM/CxCxxxxC-motif-protein-YfkAB
MRASTMPAITPAYDPWEAYVDIEEYGKLELTNIEFTTTTLCNMRCEHCAVGYTLTAKDPEALPLDLLLRRLEEIPHLRSLSITGGEPMLSLKSVDQYVIPLLRYAHERGVRTQLNSNLTLDLARYERVIPYLDVLHISHNWGTIDDFIDGGFAMMERKPTRAQREKYFQRMLDNAKAGVMVSAETMLNKRTVRHLETIHRQVVEDMGCRRHEIHPMYPSDFASALETLSLDELRKAIHHLLDIRNEDVWMLFGTLPFYPCSDNEEDVALLKRLYESKNVTVRNDPDGRSRLNVNIFTGDVIVTDFGDEPPLGNIIRDSLPDVYDQWRRSKLANELLCHCPAARCLGPNVLVKQTYYRDIDFTKRSARVARANPSH
>NZ_AP022557.1|WP_172418767.1|3475110_3476658_+|fumarate-hydratase
MEKFQQSMYDLIVETSTKLPKDVRRAIARAKVRENAGTRAAMALDTIVENIQMADENVSPICQDTGLPTFKIKVPVGVNQIEMKKAIRAAIVEATKNGKLRPNSVDSLTGKNSGDNLGEGVPVIKFEQWENDYIDVRLILKGGGCENKNIQYSLPCELEGLGRAGRDLDGIRKCILHAVYQAQGQGCSAGFIGVGIGGDRSSGYELAKEQLFRPVDDVNPIEELRQLEEYIMENANKLGIGTMGFGGESTLLGCKIGVMHRIPASFFVSVAYNCWAFRRMGVKIDPATGEIIEWLYQDGEDVDFAKELEKAEAAAALEQGDTRVIDLVPPLSEEQVRQLRVGDVVRISGMIYTGRDAIHKYLMDHDAPVDLNGQIIYHCGPVMLKDEEGRWHVKAAGPTTSIREEPYQGDIMKKFGVRAVIGKGGMGAKTLQALKEHGGVYLNAIGGAAQYYADCIKSVEGVDLLEFGIPEAMWHLRVENFTAVVTMDSHGNSLHEDVEKSSLEKLAQFKEPVFK
>NZ_AP022557.1|WP_172418768.1|3476827_3477619_+|delta-lactam-biosynthetic-de-N-acetylase
MKWLLSLLLLFTLIPAPAFAASHAPIHWGFKRSENHQPPSVGKELDELLAKYDAFYLGDTSEKTIYLTFDNGYENGYTAQILDVLKEKNVPAAFFVTGHYLQTAPELVKRMAAEGHIIGNHSWHHPDLTTASEERFREELEKVKEKTEELTGQKGMAYLRPPRGIFSERTLALARELGYYHVFWSLAFVDWQTDRQRGWRYAYDQIMKQIHPGAILLLHSVSKDNADALPKVIDDLRKQGYTFASLDELMAKKMGLHPWLFRP
>NZ_AP022557.1|WP_172418769.1|3477862_3478729_+|DNA-3-methyladenine-glycosylase-2-family-protein
MWKQTITVPAPYDFSHALERLALDPLLAVDLERQRVTVPLHLDDVKVPVAVESIGTKDAPRLIVSGPHPERQQEIIERISHLFQWRTPLASVHRHFQATELAPLFARYEGLPLVLDFDLYFCLVKCLIHQQLHLKVGYRLTERFVKTFGEERDGVWFYPRPEEIAARSYEDLRALQLSGRKAEYIVDMSRLIAEGKLRLDELRQMEDGEVMKRLTAIRGIGPWTVQNFLLFGLGRPNVFPPADIGLQRAVEQLFQLPKRPTAHELAALGERWKPYASYAALYLWRSIE
>NZ_AP022557.1|WP_172418770.1|3478725_3480132_+|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MRGTDMAKRQTKVKIRKGDQFPLTIQRIGINGEGVGYFQKQVVFVPGALPGEEVIVEATDIHPTYAEANIKRIRKRSPNRIKPPCPLYDQCGGCQLQHLAYEAQLEAKRDIVIQALRRHARRLDVDKLDIRPTIGMDDPWHYRNKSQFQVGMKEGKVLAGLYGLNSHRLIDLSECRVQHPQTTRVTNIIKTILQDLRIPIYNERTRTGVVRTIVARVGFHTGDIQVVLVTATKDIPRQELLIDEIRRRLPEVKSIVQNINGEKTSLIFGDETEVLAGDEYIQETLGDLSFELSARAFFQLNPIQTVKLYDEVKKAAALTGTERIVDAYCGVGTIGLWLARDANEVRGMDTIPEAIADAKKNAKKHGFTNTHYVVGKAEYWLPKWVNEGWKPDVIIVDPPRVGCDRALLETILRVRLQKVVYVSCNPSSLARDLDTLAAAYRVAYIQPVDMFPHTAHVECVAQIVLRET
>NZ_AP022557.1|WP_172418771.1|3480348_3481806_+|SAM-dependent-DNA-methyltransferase
MMTGELKSKVDKIWETFWTGGITNPLTVIEQFTYLLFIKGLDEVETQREQEDALLGIESERIFPPDKQHLRWSKFKHFEAAHMYEVVSNEVFPFIKNLHGNKESAYAKYMGDAMFMIPTPQLLVKIVDGIDHIPMKDRDTKGDLYEYLLSKIATAGTNGQFRTPRHIINMMVELVKPTPEDIIVDPAAGSAGFLVAAGEYLRNHRSDLFLVQSLKEHFHNQMFYGFDMDRTMLRIGAMNMMLHGIENPNIEYRDSLSEQNNDRDKYTLVLANPPFKGSLDYEAVSSDLLKVVKTKKTELLFLALFLRILKPGGRCACIVPDGVLFGSSTAHKAIRKEIVENHKLEAIISMPSGVFKPYAGVSTAIMIFTKTGAGGTDHVWFYDMKADGYSLDDKRTPIEENDIPDIIARFHNREAEKDRKRTEQSFFVPVEELRENGYDLSINKYKEIEYEEVQYEAPSVILEKVEVLEREIIQGIKELKEMIRG
>NZ_AP022557.1|WP_172418772.1|3481814_3482960_+|restriction-endonuclease-subunit-S
MGFETIKLKDLTTNLDNKRKPLNELERKSLKKKGLYPYCGANGVLDYIDEFIFDQEILCIAEDGGNWGFREKCAYIMNGPCWVNNHAHVLVAKENVNIKYLCYYLNYADLSKHITGTTRGKLTKSALEEIDVIVPDYSTQYKIVNTLDKAQELIDKRKAQIEALDQLTQSVFLEMFGDPVKNSLGFKTEPLHELCVHIFGGGTPSKSNPEYYVGNIPWVTPKDMRDIVINDSIDHINEDAIANSSAKLIPPNSLLMVIRSGILKKKLPIAINTREVTVNQDMKAFVIDKNKITVEYLLYFFEFYQKVLLNRVRSVTADNLDFQQIKEILVPVPPLNKQKEFGNIFYKVLEEKNKCLQQLNELENNFNSLMQRAFKGELFND
>NZ_AP022557.1|WP_172418773.1|3483003_3486345_+|DEAD/DEAH-box-helicase-family-protein
MRSNFQFLIGKPHYESFANACLEAEKSLVVSPATCAILTRRALELAVKWVYSFDGALKVPYQDRLSSLIHDPGFLAIIDEALLPLLRYIVKLGNVAVHTNSMITREEAILSLHNLHQFVSWIDYCYSDDYTAAEFNESLLPIGEEKRERPEELKDLYERLSSKDKRLEEMMKENEQLRALLAAKREENTKESHFQVDTLSEWETRKKYIDLDLKLAGWEFQKDVVVEYPVVGMPNQEGVGYVDYVLFGDNGKPLAVVEAKRTTADPNKGKQQAKLYADCIENMHGQRPIIFYTNGFETYLWDDLAYPARKVSGFYNKEELSLLIDRRTMKKPLKHVQINDDIANRYYQKEAVLAVCDALENKRRKALLVMATGSGKTRTAISIVDVLTRHNWVKNILFLADRKTLVTQAKNSFSHLLPNLTFCNLLDNKDNPEESRMVFSTYPTMMNAIDEAKRNDGKRLFTVGHFDLIIVDESHRSIYKKYRAIFDYFDAILLGLTATPKDEIDRNTYEVFDLENGVPTYAYELDQAVQDGYLVDYRTIETTLKFLEEGIRYDELSDEEKERYEETFDEDVGDDIDSSALNEWLFNDDTIDTVLRDVMEKGIRVEGGDKLGKTIIFAKNHRHAERIVERFDQLFPEYKGGFARVIDYSVNYYQTLIDDFSDRNKWPQIAVSVDMLDTGVDIPEVVNLVFFKKVRSKAKFWQMIGRGTRLCKDLFGPGQDKTHFLIFDYCGNFAFFRENPKGIEGKAVESLTERLFTAKLEIVKELQHLQYQQEEYIAYRHQLIDELLAEINRLNEENFRVRQHIQYVHKFQNREAWNGLTAMDVNEIKEHLAPLIVPLNDDELAKRFDLLMYTIELAKLQTNNATKPIRSVIRTAEALSKLGSIPQVQEQKYIIEKVQTEEFWSEADLFELEAVREALRDLVKFLEKETQKIYYTNFKDQVLEVKENGPMFTVNDLKNYRKKVEHYLHEHRDQMAIYKLRNNKKLTIQDVKTLEHILWNELGTQEDYQREFGATPITKLVRQIVGLDPQAANEAFSEFLSSERLNIQQSRFVKLIVDYFVKNGVMDKRVLQEEPFKTVGSIVELFQDNMDDARKIIRIIDEINRNSEDIVGA

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Crispr_ID: NZ_AP022557_35

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP022557_35

3606944-3607045

Orphan

Consensus_repeat	Method
TGCCCATGGATCTTTTCTGTGAAAATCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP022557_35

>merge|NZ_AP022557|35|3606944-3607045|CRISPRCasFinder
TGCCCATGGATCTTTTCTGTGAAAATCCCGTCGGCAAGCGTTGATTTTCATCCCCGGGTGGAGGGCAAAACGTTGCCCATGGATCTTTTCCGTGAAAATCCC

>NZ_AP022557|35|34|3606944-3607045|CRISPRCasFinder
TGCCCATGGATCTTTTCTGTGAAAATCCC	GTCGGCAAGCGTTGATTTTCATCCCCGGGTGGAGGGCAAAACGT
TGCCCATGGATCTTTTCCGTGAAAATCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP022557.1\|WP_153017114.1\|3614569_3615448_-\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NZ_AP022557.1\|WP_081897253.1\|3613496_3613997_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_AP022557.1\|WP_033844514.1\|3594399_3595563_+\|sporulation-protein-YhbH	unknown	unknown	gnl\|CDD\|274336
NZ_AP022557.1\|WP_033019306.1\|3606533_3606731_+\|small,-acid-soluble-spore-protein,-H-family	unknown	unknown	gnl\|CDD\|377962
NZ_AP022557.1\|WP_172418783.1\|3600334_3601288_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379106
NZ_AP022557.1\|WP_061912363.1\|3604624_3604897_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_172418782.1\|3598013_3598646_+\|SIR2-family-protein	unknown	unknown	gnl\|CDD\|238697
NZ_AP022557.1\|WP_081130697.1\|3598730_3600104_+\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_AP022557.1\|WP_172418781.1\|3595742_3597410_-\|IS1634-family-transposase	unknown	unknown	gnl\|CDD\|227708
NZ_AP022557.1\|WP_156102748.1\|3619387_3624580_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237191
NZ_AP022557.1\|WP_033844498.1\|3624809_3625127_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270626
NZ_AP022557.1\|WP_061912362.1\|3605023_3605428_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370164
NZ_AP022557.1\|WP_033844501.1\|3616608_3617217_+\|lecithin-retinol-acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|368215
NZ_AP022557.1\|WP_061912361.1\|3605424_3606420_-\|potassium-channel-family-protein	unknown	unknown	gnl\|CDD\|369572
NZ_AP022557.1\|WP_033844500.1\|3617727_3619191_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NZ_AP022557.1\|WP_172418845.1\|3603969_3604548_+\|leucine-rich-repeat-protein	unknown	unknown	gnl\|CDD\|275380
NZ_AP022557.1\|WP_033844506.1\|3614053_3614308_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033844497.1\|3626032_3626803_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP022557.1\|WP_033842531.1\|3607176_3608313_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_AP022557.1\|WP_033844507.1\|3609001_3612223_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911

Protein	Function_ID	Function_description	E-value
NZ_AP022557.1\|WP_153017114.1\|3614569_3615448_-\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	9.88587e-19
NZ_AP022557.1\|WP_081897253.1\|3613496_3613997_+\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	9.2624e-58
NZ_AP022557.1\|WP_033844514.1\|3594399_3595563_+\|sporulation-protein-YhbH	gnl\|CDD\|274336	TIGR02877, Stress_response_UPF0229_protein_YhbH, sporulation protein YhbH. This protein family, typified by YhbH in Bacillus subtilis, is found in nearly every endospore-forming bacterium and in no other genome (but note that the trusted cutoff score is set high to exclude a single high-scoring sequence from Nitrosococcus oceani ATCC 19707, which is classified in the Gammaproteobacteria). The gene in Bacillus subtilis was shown to be in the regulon of the sporulation sigma factor, sigma-E, and its mutation was shown to create a sporulation defect. [Cellular processes, Sporulation and germination].	0
NZ_AP022557.1\|WP_033019306.1\|3606533_3606731_+\|small,-acid-soluble-spore-protein,-H-family	gnl\|CDD\|377962	pfam08141, SspH, Small acid-soluble spore protein H family. This family consists of the small acid-soluble spore proteins (SASP) of the H type (sspH). SspH are unique to spores of Bacillus subtilis and are expressed only in the forespore compartment during sporulation of this organism. The sspH genes are monocistronic and are recognized by the forespore-specific sigma factor for RNA polymerase - sigma-G. The specific role of this protein is unclear but is thought to play a role in sporulation under conditions different from that of the common laboratory tests of spore properties.	1.01495e-17
NZ_AP022557.1\|WP_172418783.1\|3600334_3601288_+\|hypothetical-protein	gnl\|CDD\|379106	pfam13289, SIR2_2, SIR2-like domain. This family of proteins are related to the sirtuins.	0.00316522
NZ_AP022557.1\|WP_172418782.1\|3598013_3598646_+\|SIR2-family-protein	gnl\|CDD\|238697	cd01406, SIR2-like, Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.	4.22035e-14
NZ_AP022557.1\|WP_081130697.1\|3598730_3600104_+\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.25216e-16
NZ_AP022557.1\|WP_172418781.1\|3595742_3597410_-\|IS1634-family-transposase	gnl\|CDD\|227708	COG5421, COG5421, Transposase [DNA replication, recombination, and repair].	1.93774e-26
NZ_AP022557.1\|WP_156102748.1\|3619387_3624580_+\|hypothetical-protein	gnl\|CDD\|237191	PRK12757, PRK12757, cell division protein FtsN; Provisional.	0.00434528
NZ_AP022557.1\|WP_033844498.1\|3624809_3625127_+\|hypothetical-protein	gnl\|CDD\|270626	cd00893, PI4Kc_III, Catalytic domain of Type III Phosphoinositide 4-kinase. PI4Ks catalyze the transfer of the gamma-phosphoryl group from ATP to the 4-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) to generate PtdIns(4)P, the major precursor in the synthesis of other phosphoinositides including PtdIns(4,5)P2, PtdIns(3,4)P2, and PtdIns(3,4,5)P3. There are two types of PI4Ks, types II and III. Type II PI4Ks lack the characteristic catalytic kinase domain present in PI3Ks and type III PI4Ks, and are excluded from this family. Two isoforms of type III PI4K, alpha and beta, exist in most eukaryotes. The PI4K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.	0.000218143
NZ_AP022557.1\|WP_061912362.1\|3605023_3605428_+\|hypothetical-protein	gnl\|CDD\|370164	pfam08868, YugN, YugN-like family. This family of proteins related to B. subtilis YugN are functionally uncharacterized.	4.64988e-74
NZ_AP022557.1\|WP_033844501.1\|3616608_3617217_+\|lecithin-retinol-acyltransferase-family-protein	gnl\|CDD\|368215	pfam04970, LRAT, Lecithin retinol acyltransferase. The full-length members of this family, are representatives of a novel class II tumor-suppressor family, designated as H-REV107-like. This domain is the catalytic N-terminal proline-rich region of the protein. The downstream region is a putative C-terminal transmembrane domain which is found to be crucial for cellular localization, but not necessary for the enzyme activity. H-REV107-like proteins are homologous to lecithin retinol acyltransferase (LRAT), an enzyme that catalyzes the transfer of the sn-1 acyl group of phosphatidylcholine to all-trans-retinol and forming a retinyl ester.	2.72018e-26
NZ_AP022557.1\|WP_061912361.1\|3605424_3606420_-\|potassium-channel-family-protein	gnl\|CDD\|369572	pfam07885, Ion_trans_2, Ion channel. This family includes the two membrane helix type ion channels found in bacteria.	1.16922e-13
NZ_AP022557.1\|WP_033844500.1\|3617727_3619191_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	1.27332e-22
NZ_AP022557.1\|WP_172418845.1\|3603969_3604548_+\|leucine-rich-repeat-protein	gnl\|CDD\|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	4.05932e-27
NZ_AP022557.1\|WP_033842531.1\|3607176_3608313_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	5.30172e-30
NZ_AP022557.1\|WP_033844507.1\|3609001_3612223_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0

>NZ_AP022557.1|WP_033019306.1|3606533_3606731_+|small,-acid-soluble-spore-protein,-H-family
MDMNRVKQIVSSPADIPVYYNGVSVWIDGYNEETQMVTVHLRDGRLHERRDVPAAELEEKETAVD
>NZ_AP022557.1|WP_061912361.1|3605424_3606420_-|potassium-channel-family-protein
MRVRSWLVSYWRMSTALRLLVTASATIIMFGAFMPLIEPQTFRTMFDGVWWAIVTAATIGYGDIVPETVAGKLAAIVLIAVGTGIIGAYFSSVSAAAATRETAHTNGQLAYKEHGHIIIVGWNERAREMLLRLAGQDPPSRVVLIDATVPSHPLPHIPVHFIKGAAHDDAVLEKANLSHARFVLITADPHKAEEEADRDTIVALLAAKSLNPSVYAIVEILTARHVPNAFRAGADEVIQTNLLASAAMTASLYSPGTASSLERMLGRFGEQTLRLLPPTEQQIGQPFAAVQQQLLAQHIALLGVVCGDSGSLSIRPQRLIEKDDRLFVLVS
>NZ_AP022557.1|WP_061912362.1|3605023_3605428_+|hypothetical-protein
MIEIPSRLEGKQFSLHQLEQTLKPFGYEIGGGWEYDHGYFDYKIADHLGYQFLRVPFQAVDGQLDSHGTTVELGRPFLLAHKYQRGIDDFADVGNLTASFDQFAEPQDPDATVPEPLISVGKALVQELERRLLD
>NZ_AP022557.1|WP_061912363.1|3604624_3604897_-|hypothetical-protein
MNTDTIFLVKEQDAGNKQDLSGDREAFRAQEEAGSTDVCVTSVPLLGLRKEYSMARISDDTAEQEIPIDVIKKHLYVAYGYLVCLLDHGK
>NZ_AP022557.1|WP_172418845.1|3603969_3604548_+|leucine-rich-repeat-protein
MVSLDLRNNKIKDIEALGQLVNLEELDLSYNRIEQIDPLVTLTKLKKLTLSGNKISNIEVLAHLKNLQILSLNQNQIRHVDALNQLFMLKELDLGSNQIQEISFERLEKMECLYLNDNPLHSIASLSNMKNLEVLYFNGTKVDDISVLSKLKKLKLASFTMSSDPSENQIVNELLNRGVTIYINDILFSLER
>NZ_AP022557.1|WP_172418783.1|3600334_3601288_+|hypothetical-protein
MSAKVISLFAENPIIFMGYSITDENIRNFLKDIYTCLENEEEYKAFEDRLVIIEYKESVQNPIIGSHSVYFDGVQIKLTKIIVEDFTLLYKEMQKLEDIVELKDIKRLRNLVYQIVYDYKGEAKKVINLLDDEEYDGNEVVVAIGKESELLDVVGITGISAKDIFKDLVFDSLDSKLKNRYDYLVEKQLPQLLRGNTVLPVHKYLQKIENESVIIDEKVRKMAGYSPEDLLNNNIKKDREAYLESKFSSLEEIVNSNLPSTKKLNFLVLRAALHADDKELKSFLRTHYKEFESYRFGPTMLRKMICILDIKAYKSSA
>NZ_AP022557.1|WP_081130697.1|3598730_3600104_+|IS1380-family-transposase
MKDFPIRFVLTDEAITPSAGLALVGYLLHRTKLDKRVNALRLPTVRREVHISHSDVIRSMIGLLATGKTDFDHIEAYRQDDIFSASMGIQHVPSSPTLRQRLDQLACLPMTEAIIWEESMRLLVRQHATLSPCWTKGKTTWLPLDVDGSPFDNSDTKKEGVSRTYKGFDGFTPLFAYAGKEGYIVHAELRPGKQHVQDNMPSFLTTAIRRARPLTSSRLLVRMDAGNDAEANVHVCLKEDVDFVIKRNLRRESKALWFQIASQKGRRIDDGQTEGVQTYELCLPQKVAIDGNTYTYVQVTQVTERTMERNGQLMLVPNYEVESYWVRLEGYEHVRMSDVLALYHDHATCEQFHSELKSDLDLERLPSGKMKTNAIVLVMGAFVYNLLRLIGQDLLSDPRHPLHHKVKRRRIKTIIQTVITMAGLLVRRSRQIWMKLTRRSGYSEPLLNVYQKWREAR
>NZ_AP022557.1|WP_172418782.1|3598013_3598646_+|SIR2-family-protein
MSENQVTLESIFQNIRDTKRLPVIFIGSGITKRYTDKKYSWEGLLKRCIEEYDDNPTNKYKWYRQKIRSQYNIDDNDSHQMYKYLGTYIENDFNLNYYEGKIRSLSVPEEEKSPLKYFIKELLRTYKIDENMYEEIEELKKLKDKMITVITTNYDTFLEDHIFTNHERLIKQKMFVYSELGTLFKIHGCISEPSSIVLTYQDYENFNLNP
>NZ_AP022557.1|WP_172418781.1|3595742_3597410_-|IS1634-family-transposase
MYIRRVTRKNKDGTTVAYLQLAHNEWDPKAKYAKAKVIYSFGREDEVDRAVLERLAKSISRFLSPEQAWEVETLTGEASDDFQFQSCKHLGGVWLLDQLWRQLGLGEILHSLFTSRHHQISLERLIFAMVANRALHPSSKLAMEEWVEKDVYIPHLPQAASHQLYRAMDELLAVQPELERQVFHAVADLLNLEVDLIYFDTTSSYFEVDPSETPEGESLRKQGFSKDKRPDLVQIVIGLAVTREGIPIRAWVWPGNTMDMTVIKQVKQDLIGWKLGRVISVMDRGFSSEENLRILQQAGGHYIVGEKMRSGKAAVEEALSRRGRYHEVDENLHIKEIIVGDGEARQRYVLVYNPSEAERQRKERETLLESLKEELKGLRQLLNEAHHKATCRLRSHPSYGKYLRQLKDGTLRIDKQAVRDAEKYDGNYLIRTSDDTLSAEDVAIGYKQLVDIEQAFRTLKSTLELRPMYHRLEDRIRAHVLLSWLALLLVRIVEIRTHESWPNVRDECERLMLGHFSSKNGDLNQRTELTVKQAQFFAALGLEPPPKILGIHPRT
>NZ_AP022557.1|WP_033844514.1|3594399_3595563_+|sporulation-protein-YhbH
MKGNFVVSKEDWSLHRKGHDDQKRHQEKVKEAIKNNLPDLITEESIIMSNGRDVIKIPIRSLDEYKIRYNYEKNKHVGQGNGDSQVGDVVAKDGSGEGQGPGKGQGAGDLPGQDYYEAEVSLMEIEEALFSQLELPNLQRKELDQHIVQQIEFNDIRRTGLMGNIDKKRTMLAAFKRNAMSGKPSFYPIYREDLKFKTWNEVIKPESKAVVLAMMDTSGSMGMWEKYMARSFFFWMTRFLRTKYETVDIAFIAHHTEAKVVSEEEFFTKGESGGTICSSAYRKALELIETKYSPSRYNIYPFHFSDGDNLTSDNARCVKLVQELLKVSNMFGYGEVNQYNRSPSTLMRAYGNMKHEKFRYYILKQKADVFEALKYFFSAEKKRGRRL
>NZ_AP022557.1|WP_033842531.1|3607176_3608313_-|IS110-family-transposase
MDVIYPRCAGLDVHAETIVACALWEEDGHIQKDIQTFSTFSKGLGDLLEWLEEHGVTHVAMESTGVYWKPVFAFLEGYVDLTLANPQRIKNVPGRKTDVSDAEWIAKLLRHGLIEKSFVPPADIRELRDFTRLRKKWVGQLSSEKNRIQKVLESSNVKLGSVLSDLFGVSGRNILARLLEKGYVDKDELDQCLRGRLKTKKQAVYDSLLGTLTEHELRLLRLLWKHVEELEQLIEEVDQHIDRLLEPYREEVDLLMTMPGIKKQTAAVIIAEMGTDMSVFETPERVASWTGLSPGNHESAGKRKSTRTTKGNPHLRSALCEAAWSAARSKTHPLSRKFWSLAARCGKKKALIATARRMLVIIFCMISRKESFRQPQLI
>NZ_AP022557.1|WP_033844507.1|3609001_3612223_+|efflux-RND-transporter-permease-subunit
MRSIIQFSLNNKLAVWILTLIVAVAGLYSGVGMKLETIPNINVPFISVSTVYPGATPEEVDKKVTQPIERQVEHLDGVTAVRSSSFQNASFVQIEYDFGKDMGTAQNEVKEALSHLQLPDGVQEPDVSRISFSAFPVISLSITDRHRSLAELTKIVEREIVPELEGIDGVDSVEVAGQQMQEVNIRFDEQKLKRYGLTEQSVINVIQASAVSLPLGLYTFGDTEKSVVIDGRIATIDDLKALRIPIVSGAGAAPSPVVGAEVEGRGQGSAIDGQAGGQGAAALAPGAGSGPQGRDARGAENSAVGQTGRSAAIPSVPLSELAEVKVVAKAESISRTNGKPSIGVQVVKAQDANTVTVVNAVKEKSKDLEKRFDGLRIITVFDQGKPIEDSVNTMVDKAVFGALFAVVVIFLFLRNIRTTLISVVSIPLSLLMAILLLREMDITLNLMTLGAMTVAIGRVIDDSIVVVENIYRRMTLPGESLSGKELIASATKEMFIPIASSTIVTVAVFLPLGLVKGMVGELFLPFALTIVFALLSSLLVAVTVVPALAHSLFSKGVAAKDVRVRERKQTLAFWYKRVLRWSLDHKFIVSGTAVLLLISSLFLVPRVGVSFLPSDEQKMIVVTYSPAPGQTVDEVERIAKEVESFFEQRQGVKNIQLSVGGGNPMNPGQDHAALFYVEYDHDVKRFAEEKERVMKALDERKDKGEWQSQDASSSGTSNVLELNVYGSSMEEIEPIVRQAADLLRGHEELVNVKTSMAARFEEYTLAANQNKLSELGLTAAQVAAALSEKGGRQAIATVKQDGEDLSVYLADENKRYADIADLLENTITSPLGIEVPIKDLVTVKKGYTYSEIERDDGRVHASVSAEVKTKDVAAVSAAVQKELKRLDLPSGVDIQMGGVTEDIQESFTQLGWAMLAAVAIVYFVLVVTFGGGLAPFAILFSLPFTVIGALLALFVSGETISVSAMIGMLMLIGIVVTNAIVLIDRVIHKEREGLSTREALLEAAGTRVRPIFMTAIATIGALLPLAVGMEGGALISKGLGVTVIGGLTSSTLLTLIIVPIVYETLMKWRKKRA
>NZ_AP022557.1|WP_081897253.1|3613496_3613997_+|N-acetyltransferase
MERWLIRDATAADLPHIVRIYNETIPSRMVTADLEPVSVESRKAWFEAHDPHHRPLWVVEDGGEICAWLSFQSFYGRPAYRHTAEVSIYIAESHRGQGLGTKLLKQAVDKAPDLEMKTLLGFIFAHNEPSLRLFARFGFERWGYFPRVAELDGIERDLVIVGKRLV
>NZ_AP022557.1|WP_033844506.1|3614053_3614308_+|hypothetical-protein
MNVMPIRLFTIQDGEGFVADAFQCPVTGNLIYKSSGTSSVIAYSELTDEQIARLEPYGFRRLEGTQGRAVHEDAAGIEALLPRQ
>NZ_AP022557.1|WP_153017114.1|3614569_3615448_-|thermonuclease-family-protein
MIVWPDSVSAHPGSLDELGGHFRNSDCTYVLHEPTALAKQAKTKAELVKLIQTYNSNERCKRKLTPERIDLDGHALGGKDNAVSLRLGRTYKATLTQCIDGDTAKFRVNGRVYTTRFLFIDTPESTIEIEPYGKEASRFTCSRLQKGKVVLETDGNTLFDRYHRLLAWVWVDGRLLQEDLAKAGLVEDFYDYGRYKYESRVRKALEEAKRNGIGMYGERSVAKHEQARSKTKQEGATNTAPQTESETEPTDRAPSRKQETAAFERSGLPLLYPLLGAAAAVAVYWLVRQLRR
>NZ_AP022557.1|WP_033844501.1|3616608_3617217_+|lecithin-retinol-acyltransferase-family-protein
MEFFKNVKWFFEELHEANKEFVSGVRQDVKEFRTDMKDIVKEHNPTMGKAIEGADRLAQAIGNFIKSNPTIFEPKNTIVPDMKSIRESKEWKELKRDSELELADHLIAKRIEYGIGYTHHGLYIGNNQVIHYSEGEVRIDSLEDFKKDCEIRVIDSVATYSKEEIISRAFSRLGEKRYNLVFNNCEHFVNWCRSGGKMTDSI
>NZ_AP022557.1|WP_033844500.1|3617727_3619191_+|copper-amine-oxidase-N-terminal-domain-containing-protein
MKPNQKGSVVSTNTQVHMTSVYTRNKGTNKSVKRSFSLVISNLLISTVLMGALGISGGTVEAVSSTQTPTQVAQVTQKYQDDATLLANVNLALDVLKKNGLTLATLSLLHSSLKDIENKVNANQFTSTNNLYKTLVLAESTLSGLSYNITLDVRNEYVESLTVVKRLTPISVYIDGVPQFYKQQPIEQNGIVFVPLRDIYEKLGAKVTSDTKTNTVIITKGNTVIKLPRGKDFAYVNGKSVKLSAKMFINNGVTMIPVDFLKVSLGSSVEWLSVPKVVVITSKAQTVNGIKVLYGGHTYDSRNQKEYDTVMKIVREHISKEYDKLVFGESRNKYYLEYLDGARFNGDKRDRSERNVGLYLAQGSIGDLVSAGVSKEGVIRAWKTGFLAGILADGTVNPGDGKPRSAYDNLVRRISDCDADAQVYSAVWDAMGYNTLIIAGSGHADMLVQIEGHWFKPGAGSFMRVDLNSSLKKGAKIIFQSTYGQIK
>NZ_AP022557.1|WP_156102748.1|3619387_3624580_+|hypothetical-protein
MLKVSSSVLALSLIFSSVSTAALANSDSAVTVQENQATEQQRTESVTVESSGVSTTSEVNNQIISDQLASNGLEGGQDAVNSQEGNQQFTPQKENQQPQPEDQQVTPQQENQQSQPENQQVTSQPKDEQVKDQVVTDKSGRVVKDGLYVDIYYTPEQSESTYIPEFTLELWSVKENKLIGTAIANSKNYDRESGVYHLMFNHRGYKLGDEFALIPRKADKVFKYIEFVDEEAYNVKPNTYYKFGIKTFDYYEGEEGKEVAIRDLTGTKLSPIGGALYTDNNKVGLALVDESGAPLKKFHIEIKLSDKKGSLSLVSDDKGMVWVDRDKLTPKFLVSSEDRVVKGGINGKALIELPVSAVTGGQTGVLTYSVVFEHKKELGVIDLKPEVSGNTDLSKSWAEADIKLTNGKTVITQTVNLNTQKIYGIPDGTYKVEVVKSKYANVKLRTSTVTVKGGTASLGIVFSPKYVLEVDKDGKDYNFSVINVDKISKKAYKGKSSQVFAVAPGESYMLKDNDTGKITTVAIDLKSFKTKVVLGVGVVFGGTVSTPHTGDDIYIMLVLFMLSLIGAIGSYVFYRKNGKISAPKTKLMSILLVGALLTSIFSSFAPLSVVASDTNIGGTPPAKGGATSGTPAGTFQTSDRVAVVQVGFIPNKLKANGVGILNSESSKQDLQDPFKFNYDHLLFYMAPNKVSDGLFRKMGSGVITFENKGSSSRVKTLYGKNPLYKGSTGGQSREELMKRTLSYADISKNSDNAFVSIVGNALYNIDPKNPNRTLAGPGVVGESFRDMLEWYVLSMEGYDNDAYAKAALDMFNGYLELIKVRGILKGEQYDKFERMMREAYRNKEVVFFAQTLVGISVKDNQSPLSRDYAFMSIHDATDWYLWVRKKARPTDSKLKKLSANREAEAVTKGGASTEADGLRSPYKENGNIPFTFRTYARDNYARTLKPMSKNVPLTADVSKNPFGGWGYQPWGYIYLEDRVKAPKIDVMLDVSIVDKTGARKGGFRTPVKGWSESDNKFLGRLTSEDSKIIKGGMTFVYKGKTYQILQEEKAKFTLVDKRDNENINKSTLTKSSKGEDGYISLNNPNTWEIMLGWDTPEPVYLHTYLGGDGDNILSVENKYEGVKEKGKDVFSNARLTLYVKAVEDTNVSASIHDVPEWRLSKYFEDISKNSVAKAIFSLTLPSETFINPVLSPTGDVNFSLIHPDLSNVKWAYSKAKLFNDTTIKYLSAYDTVAAFNLAGDLLAVKDNSSVGNVKLASWVNPYSLFDGRIGVTDKGVAENKPSVVKNYMFKYGVRSPYASYGYSETRYRWVPPTYDKDGKMISSGYYVPYTWSGQATSSAKTADYDVTVNFRRHIPKANQAPKKFKDVVTSVNGKYTEVKQDKQVLNINPEIPMVYDDVNGNTSVAFVAGDKMRQVQPVHYNVAQFVNVDIKPSVTGMSVATDANAKALASRLGANGKGVLYKGSAVTTNFQTKGQLELKTFALDIGATSLKNAWNPSTTYSTDKLNEEFLSRYATKKSDGTWEVTLNAEGKLKINGVEYGGKKKAIKLKQKSRNVVEHTLLVRGGKLVAVDGNYDLNSLPQGLKEALAKMHISTLVGQNIFNTFENGTGAKLTEQKVADLINAVRGTKDLATGKGWYAEDTTILVVREYTNSFELPSYLYTDKVPMQVPNLETPINKTEFFSKGYIGYTKLTFRLADSFMEYDSSQAKPFGGKHEKSFVVGNVSVLDTFQ
>NZ_AP022557.1|WP_033844498.1|3624809_3625127_+|hypothetical-protein
MAKLSREVLIKRFPWAAEVVPEVNESEGYFYDLDPWDFSQEQFKLLEQMFEEIDNWFKQRDLPVDVVVYRVANVLDSIHVELFSNVSEVHTIVKKYKQFSRDLIE
>NZ_AP022557.1|WP_033844497.1|3626032_3626803_+|hypothetical-protein
MKNMEIKSEQSKELILPQNDKSEKVADFVNQNWKLELLWGWNSEDGCYHYAVRFTSKAKNPKNIVQSVVIMKEDLEDKRLMHENLRKLGRIGKIEQRYLVAISSFISDVITKDGVPIEEVEDMYDFKKAESPLPHWINLDEIISKIEREIENNAWRFPLKTSNEFSKEDSHGAILDHKKQYKGYKHPVAIQASVLRQWIKEWVGVRADRLYREILEELIKRGVIEGNIEDRRLSKNITVAENVEISAYQFNFLPRG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP022557_1	1.1\|359730\|39\|NZ_AP022557\|CRISPRCasFinder	359730-359768	39	NZ_AP022557.1	2177426-2177464	0	1.0
NZ_AP022557_20	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	NZ_AP022557.1	1818390-1818433	0	1.0
NZ_AP022557_20	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	NZ_AP022557.1	3147228-3147271	0	1.0
NZ_AP022557_20	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	NZ_AP022557.1	3419522-3419565	0	1.0
NZ_AP022557_24	24.35\|3255092\|37\|NZ_AP022557\|CRISPRCasFinder,CRT	3255092-3255128	37	NZ_AP022559.1	34130-34166	0	1.0
NZ_AP022557_25	25.28\|3267144\|37\|NZ_AP022557\|CRISPRCasFinder,CRT	3267144-3267180	37	NZ_AP022559.1	34130-34166	0	1.0
NZ_AP022557_30	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	NZ_AP022557.1	3685424-3685467	0	1.0
NZ_AP022557_30	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	NZ_AP022557.1	2538381-2538424	0	1.0
NZ_AP022557_30	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	NZ_AP022557.1	3147525-3147568	0	1.0
NZ_AP022557_30	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	NZ_AP022557.1	3149298-3149341	0	1.0
NZ_AP022557_30	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	NZ_AP022557.1	3149443-3149486	0	1.0
NZ_AP022557_30	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	NZ_AP022557.1	3270723-3270766	0	1.0
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_AP022557.1	742942-742987	0	1.0
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_AP022557.1	2540302-2540347	0	1.0
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_AP022557.1	2540518-2540563	0	1.0
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_AP022557.1	3145378-3145423	0	1.0
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_AP022557.1	3419082-3419127	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	638239-638286	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	2540417-2540464	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	2540488-2540535	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3145348-3145395	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3270472-3270519	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3421398-3421445	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3511340-3511387	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3685523-3685570	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3687450-3687497	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3687521-3687568	0	1.0
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3687592-3687639	0	1.0
NZ_AP022557_34	34.1\|3471262\|49\|NZ_AP022557\|CRISPRCasFinder	3471262-3471310	49	NZ_AP022557.1	966270-966318	0	1.0
NZ_AP022557_34	34.1\|3471262\|49\|NZ_AP022557\|CRISPRCasFinder	3471262-3471310	49	NZ_AP022557.1	3391137-3391185	0	1.0
NZ_AP022557_20	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	NZ_AP022557.1	3686156-3686199	1	0.977
NZ_AP022557_30	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	NZ_AP022557.1	743014-743057	1	0.977
NZ_AP022557_30	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	NZ_AP022557.1	2540232-2540275	1	0.977
NZ_AP022557_6	6.1\|851097\|41\|NZ_AP022557\|CRISPRCasFinder	851097-851137	41	NZ_AP022557.1	3178601-3178641	2	0.951
NZ_AP022557_20	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	NZ_AP022557.1	742872-742915	2	0.955
NZ_AP022557_20	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	NZ_AP022557.1	743018-743061	2	0.955
NZ_AP022557_20	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	NZ_AP022557.1	2540228-2540271	2	0.955
NZ_AP022557_20	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	NZ_AP022557.1	3685644-3685687	2	0.955
NZ_AP022557_20	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	NZ_AP022557.1	3689930-3689973	2	0.955
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_AP022557.1	2540083-2540128	2	0.957
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_AP022557.1	3151214-3151259	2	0.957
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_AP022557.1	3272565-3272610	2	0.957
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_AP022557.1	3419302-3419347	2	0.957
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_AP022557.1	3688077-3688122	2	0.957
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	2538349-2538396	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3147493-3147540	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3149266-3149313	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3149411-3149458	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3151184-3151231	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3270691-3270738	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3741528-3741575	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3419330-3419377	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3419401-3419448	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3685452-3685499	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3685816-3685863	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3685887-3685934	2	0.958
NZ_AP022557_32	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	NZ_AP022557.1	3688105-3688152	2	0.958

1. spacer 1.1|359730|39|NZ_AP022557|CRISPRCasFinder matches to position: 2177426-2177464, mismatch: 0, identity: 1.0

aaattatgagccaaaaaaatatcggcgcgcttccggttg	CRISPR spacer
aaattatgagccaaaaaaatatcggcgcgcttccggttg	Protospacer
***************************************

2. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to position: 1818390-1818433, mismatch: 0, identity: 1.0

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	Protospacer
********************************************

3. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to position: 3147228-3147271, mismatch: 0, identity: 1.0

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	Protospacer
********************************************

4. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to position: 3419522-3419565, mismatch: 0, identity: 1.0

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	Protospacer
********************************************

5. spacer 24.35|3255092|37|NZ_AP022557|CRISPRCasFinder,CRT matches to position: 34130-34166, mismatch: 0, identity: 1.0

aatacatcgccgtgcgggcgcggaaggtggcgtagtc	CRISPR spacer
aatacatcgccgtgcgggcgcggaaggtggcgtagtc	Protospacer
*************************************

6. spacer 25.28|3267144|37|NZ_AP022557|CRISPRCasFinder,CRT matches to position: 34130-34166, mismatch: 0, identity: 1.0

aatacatcgccgtgcgggcgcggaaggtggcgtagtc	CRISPR spacer
aatacatcgccgtgcgggcgcggaaggtggcgtagtc	Protospacer
*************************************

7. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to position: 3685424-3685467, mismatch: 0, identity: 1.0

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	Protospacer
********************************************

8. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to position: 2538381-2538424, mismatch: 0, identity: 1.0

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	Protospacer
********************************************

9. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to position: 3147525-3147568, mismatch: 0, identity: 1.0

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	Protospacer
********************************************

10. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to position: 3149298-3149341, mismatch: 0, identity: 1.0

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	Protospacer
********************************************

11. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to position: 3149443-3149486, mismatch: 0, identity: 1.0

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	Protospacer
********************************************

12. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to position: 3270723-3270766, mismatch: 0, identity: 1.0

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	Protospacer
********************************************

13. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to position: 742942-742987, mismatch: 0, identity: 1.0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

14. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to position: 2540302-2540347, mismatch: 0, identity: 1.0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

15. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to position: 2540518-2540563, mismatch: 0, identity: 1.0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

16. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to position: 3145378-3145423, mismatch: 0, identity: 1.0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

17. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to position: 3419082-3419127, mismatch: 0, identity: 1.0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

18. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 638239-638286, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

19. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 2540417-2540464, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

20. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 2540488-2540535, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

21. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3145348-3145395, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

22. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3270472-3270519, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

23. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3421398-3421445, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

24. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3511340-3511387, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

25. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3685523-3685570, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

26. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3687450-3687497, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

27. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3687521-3687568, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

28. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3687592-3687639, mismatch: 0, identity: 1.0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

29. spacer 34.1|3471262|49|NZ_AP022557|CRISPRCasFinder matches to position: 966270-966318, mismatch: 0, identity: 1.0

tcgcgagattttcatgtctgggtggagggccgatcaccgcccatggatc	CRISPR spacer
tcgcgagattttcatgtctgggtggagggccgatcaccgcccatggatc	Protospacer
*************************************************

30. spacer 34.1|3471262|49|NZ_AP022557|CRISPRCasFinder matches to position: 3391137-3391185, mismatch: 0, identity: 1.0

tcgcgagattttcatgtctgggtggagggccgatcaccgcccatggatc	CRISPR spacer
tcgcgagattttcatgtctgggtggagggccgatcaccgcccatggatc	Protospacer
*************************************************

31. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to position: 3686156-3686199, mismatch: 1, identity: 0.977

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagtttggcattttcacggaaaagttccatgggcagtgtgatc	Protospacer
******.*************************************

32. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to position: 743014-743057, mismatch: 1, identity: 0.977

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcagcgt	Protospacer
****************************************.***

33. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to position: 2540232-2540275, mismatch: 1, identity: 0.977

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcagcgt	Protospacer
****************************************.***

34. spacer 6.1|851097|41|NZ_AP022557|CRISPRCasFinder matches to position: 3178601-3178641, mismatch: 2, identity: 0.951

ccgttccatttccgcataccaaagcgccagcttcagcccga	CRISPR spacer
ccgttccatttccgcataccaaagcgccaatttcagcccga	Protospacer
*****************************..**********

35. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to position: 742872-742915, mismatch: 2, identity: 0.955

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagatccatgggcagcgtgatc	Protospacer
************************* ***********.******

36. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to position: 743018-743061, mismatch: 2, identity: 0.955

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagatccatgggcagcgtgatc	Protospacer
************************* ***********.******

37. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to position: 2540228-2540271, mismatch: 2, identity: 0.955

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagatccatgggcagcgtgatc	Protospacer
************************* ***********.******

38. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to position: 3685644-3685687, mismatch: 2, identity: 0.955

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagatccatgggcagcgtgatc	Protospacer
************************* ***********.******

39. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to position: 3689930-3689973, mismatch: 2, identity: 0.955

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagatccatgggcagcgtgatc	Protospacer
************************* ***********.******

40. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to position: 2540083-2540128, mismatch: 2, identity: 0.957

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaacgttt	Protospacer
*****************************************.* **

41. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to position: 3151214-3151259, mismatch: 2, identity: 0.957

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaacgttt	Protospacer
*****************************************.* **

42. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to position: 3272565-3272610, mismatch: 2, identity: 0.957

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaacgttt	Protospacer
*****************************************.* **

43. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to position: 3419302-3419347, mismatch: 2, identity: 0.957

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaacgttt	Protospacer
*****************************************.* **

44. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to position: 3688077-3688122, mismatch: 2, identity: 0.957

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaacgttt	Protospacer
*****************************************.* **

45. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 2538349-2538396, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

46. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3147493-3147540, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

47. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3149266-3149313, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

48. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3149411-3149458, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

49. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3151184-3151231, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

50. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3270691-3270738, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

51. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3741528-3741575, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatcaccgc	Protospacer
*******************************************  ***

52. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3419330-3419377, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

53. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3419401-3419448, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

54. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3685452-3685499, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

55. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3685816-3685863, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

56. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3685887-3685934, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

57. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to position: 3688105-3688152, mismatch: 2, identity: 0.958

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP022557_23	23.1\|3241845\|38\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3241845-3241882	38	AB823818	Phage phi OH2 DNA, complete genome	15142-15179	0	1.0
NZ_AP022557_23	23.6\|3242178\|39\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3242178-3242216	39	NC_009737	Bacillus virus 1, complete genome	28227-28265	0	1.0
NZ_AP022557_24	24.8\|3253307\|39\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3253307-3253345	39	NC_009737	Bacillus virus 1, complete genome	28227-28265	0	1.0
NZ_AP022557_24	24.35\|3255092\|37\|NZ_AP022557\|CRISPRCasFinder,CRT	3255092-3255128	37	NZ_AP022559	Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence	34130-34166	0	1.0
NZ_AP022557_25	25.28\|3267144\|37\|NZ_AP022557\|CRISPRCasFinder,CRT	3267144-3267180	37	NZ_AP022559	Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence	34130-34166	0	1.0
NZ_AP022557_26	26.3\|3268512\|30\|NZ_AP022557\|PILER-CR,CRT	3268512-3268541	30	NZ_CP020031	Geobacillus thermodenitrificans strain T12 plasmid pGeo12a, complete sequence	53420-53449	0	1.0
NZ_AP022557_26	26.3\|3268512\|30\|NZ_AP022557\|PILER-CR,CRT	3268512-3268541	30	NZ_CP020032	Geobacillus thermodenitrificans strain T12 plasmid pGeo12b, complete sequence	52962-52991	0	1.0
NZ_AP022557_26	26.3\|3268512\|30\|NZ_AP022557\|PILER-CR,CRT	3268512-3268541	30	NC_009329	Geobacillus thermodenitrificans NG80-2 plasmid pLW1071, complete sequence	34377-34406	0	1.0
NZ_AP022557_26	26.3\|3268512\|30\|NZ_AP022557\|PILER-CR,CRT	3268512-3268541	30	NZ_CP016918	Parageobacillus thermoglucosidasius strain TM242 plasmid pNCI002, complete sequence	6505-6534	0	1.0
NZ_AP022557_26	26.3\|3268512\|30\|NZ_AP022557\|PILER-CR,CRT	3268512-3268541	30	NZ_CP049704	Parageobacillus toebii NBRC 107807 strain DSM 14590 plasmid pDSM14590, complete sequence	43017-43046	0	1.0
NZ_AP022557_26	26.3\|3268512\|30\|NZ_AP022557\|PILER-CR,CRT	3268512-3268541	30	NZ_CP017691	Geobacillus thermodenitrificans strain ID-1 plasmid pLDW-2, complete sequence	42554-42583	0	1.0
NZ_AP022557_26	26.3\|3268512\|30\|NZ_AP022557\|PILER-CR,CRT	3268512-3268541	30	NZ_CP016624	Parageobacillus thermoglucosidasius strain Wild Type plasmid pNCI002, complete sequence	6505-6534	0	1.0
NZ_AP022557_26	26.3\|3268512\|30\|NZ_AP022557\|PILER-CR,CRT	3268512-3268541	30	NC_010420	Geobacillus stearothermophilus plasmid pGS18, strain 18	56098-56127	0	1.0
NZ_AP022557_28	28.9\|3355230\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3355230-3355264	35	AB823818	Phage phi OH2 DNA, complete genome	10906-10940	0	1.0
NZ_AP022557_23	23.2\|3241913\|35\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3241913-3241947	35	NZ_CP015439	Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence	199073-199107	1	0.971
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MH617573	Microviridae sp. isolate ctbf823, complete genome	4212-4241	3	0.9
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP014451	Enterococcus faecium strain ATCC 700221 plasmid unnamed2, complete sequence	53045-53074	3	0.9
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_LR135341	Enterococcus faecium isolate E7356 plasmid 3	22974-23003	3	0.9
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_011364	Enterococcus faecium plasmid pMG1, complete sequence	20089-20118	3	0.9
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP014535	Enterococcus faecium strain E745 plasmid pl6, complete sequence	18852-18881	3	0.9
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_007594	Enterococcus faecium plasmid pHT beta, complete sequence	9402-9431	3	0.9
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP019972	Enterococcus faecium isolate 2014-VREF-114 plasmid p114-2 sequence	12300-12329	3	0.9
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP018130	Enterococcus faecium strain A_020709_82 plasmid unnamed2, complete sequence	27786-27815	3	0.9
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_LR135299	Enterococcus faecium isolate E7429 plasmid 3	49485-49514	3	0.9
NZ_AP022557_27	27.1\|3352159\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352159-3352194	36	NZ_CP015439	Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence	192692-192727	3	0.917
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NC_007103	Bacillus cereus E33L plasmid pE33L466, complete sequence	348469-348504	4	0.889
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NC_007103	Bacillus cereus E33L plasmid pE33L466, complete sequence	159835-159870	4	0.889
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP009967	Bacillus cereus E33L plasmid pBCO_1, complete sequence	162333-162368	4	0.889
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP009967	Bacillus cereus E33L plasmid pBCO_1, complete sequence	439914-439949	4	0.889
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP015592	Bacillus cereus strain AR156 plasmid pAR460, complete sequence	246119-246154	4	0.889
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP009368	Bacillus cereus strain FM1 plasmid unnamed, complete sequence	100024-100059	4	0.889
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP009368	Bacillus cereus strain FM1 plasmid unnamed, complete sequence	365571-365606	4	0.889
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP009336	Bacillus thuringiensis strain HD1011 plasmid 1, complete sequence	219836-219871	4	0.889
NZ_AP022557_23	23.2\|3241913\|35\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3241913-3241947	35	AB823818	Phage phi OH2 DNA, complete genome	16695-16729	5	0.857
NZ_AP022557_26	26.5\|3268644\|30\|NZ_AP022557\|PILER-CR,CRT	3268644-3268673	30	KY385423	Klebsiella phage vB_KpnP_KpV74, complete genome	12382-12411	5	0.833
NZ_AP022557_26	26.5\|3268644\|30\|NZ_AP022557\|PILER-CR,CRT	3268644-3268673	30	KX211991	Klebsiella phage vB_KpnP_KpV475, complete genome	12032-12061	5	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NC_010180	Bacillus mycoides KBAB4 plasmid pBWB401, complete sequence	334164-334199	5	0.861
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP015592	Bacillus cereus strain AR156 plasmid pAR460, complete sequence	65042-65077	5	0.861
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP009368	Bacillus cereus strain FM1 plasmid unnamed, complete sequence	185713-185748	5	0.861
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP009368	Bacillus cereus strain FM1 plasmid unnamed, complete sequence	215926-215961	5	0.861
NZ_AP022557_12	12.1\|1424425\|33\|NZ_AP022557\|CRISPRCasFinder	1424425-1424457	33	NZ_CP051164	Geobacillus subterraneus strain CPW16 plasmid pBsrF30, complete sequence	14178-14210	6	0.818
NZ_AP022557_25	25.17\|3266419\|34\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3266419-3266452	34	MT774386	CrAssphage cr110_1, complete genome	56004-56037	6	0.824
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP031066	Bacillus sp. SH8-8 plasmid pl193, complete sequence	49033-49062	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP004874	Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB74, complete sequence	51682-51711	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP015154	Bacillus thuringiensis strain Bc601 plasmid pBTBC4, complete sequence	4018-4047	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP013059	Bacillus thuringiensis strain YWC2-8 plasmid pYWC2-8-4, complete sequence	7426-7455	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	CP024687	Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-3-257K, complete sequence	49740-49769	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_018686	Bacillus thuringiensis MC28 plasmid pMC183, complete sequence	37748-37777	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP031063	Bacillus sp. AR4-2 plasmid pl192, complete sequence	49033-49062	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP018742	Bacillus cereus strain FORC_047 plasmid pFORC47_2, complete sequence	74167-74196	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_MG710485	Bacillus thuringiensis serovar israelensis strain Bti-UFT6.51 plasmid pBtiUFT6.51.1 complete sequence	51624-51653	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP046399	Bacillus sp. A260 plasmid unnamed11, complete sequence	162040-162069	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP011351	Bacillus thuringiensis strain YC-10 plasmid pYC3, complete sequence	690-719	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP015180	Bacillus thuringiensis serovar alesti strain BGSC 4C1 plasmid pBMB71, complete sequence	64546-64575	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP020746	Bacillus mycoides strain Gnyt1 plasmid unnamed3, complete sequence	84061-84090	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_020240	Bacillus thuringiensis serovar kurstaki str. HD73 plasmid pAW63, complete sequence	64627-64656	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	AP014409	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C28-MedDCM-OCT-S37-C188, * SEQUENCING IN PROGRESS *, 6 ordered pieces	3503-3532	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	HQ670749	Cellulophaga phage phi47:1, * SEQUENCING IN PROGRESS *, 6 unordered pieces	53587-53616	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_KY290886	Enterococcus faecalis strain Transconjugant T4 plasmid pJH-T4, complete sequence	48737-48766	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP027515	Enterococcus faecium strain AUSMDU00004028 plasmid unnamed3, complete sequence	5602-5631	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	214678-214707	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_022875	Bacillus thuringiensis YBT-1518 plasmid pBMB0230, complete sequence	23314-23343	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	KJ094023	Listeria phage LP-101, complete genome	5151-5180	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP041255	Enterococcus faecium strain 515 plasmid p32, complete sequence	7672-7701	6	0.8
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MT500540	Listeria phage LP-HM00113468, complete genome	39772-39801	6	0.8
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NC_010180	Bacillus mycoides KBAB4 plasmid pBWB401, complete sequence	328003-328038	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP015355	Bacillus thuringiensis strain MYBT18246 plasmid p109822, complete sequence	65745-65780	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP031072	Bacillus mycoides strain BPN401 plasmid pl395, complete sequence	48541-48576	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP031072	Bacillus mycoides strain BPN401 plasmid pl395, complete sequence	99514-99549	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP031072	Bacillus mycoides strain BPN401 plasmid pl395, complete sequence	94091-94126	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP020744	Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence	354090-354125	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP020744	Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence	394621-394656	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP020744	Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence	420075-420110	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP020744	Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence	39626-39661	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP020744	Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence	176913-176948	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP020744	Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence	196137-196172	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP020744	Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence	355275-355310	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP020744	Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence	374740-374775	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP009691	Bacillus mycoides strain ATCC 6462 plasmid pBMX_1, complete sequence	186491-186526	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NC_022882	Bacillus thuringiensis YBT-1518 plasmid pBMB0233, complete sequence	43349-43384	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NC_022874	Bacillus thuringiensis YBT-1518 plasmid pBMB0229, complete sequence	26545-26580	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NC_022874	Bacillus thuringiensis YBT-1518 plasmid pBMB0229, complete sequence	32582-32617	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	CP037991	Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence	296465-296500	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	CP037991	Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence	402817-402852	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	CP037991	Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence	137727-137762	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	CP037991	Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence	174027-174062	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	CP037991	Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence	393869-393904	6	0.833
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NC_022876	Bacillus thuringiensis YBT-1518 plasmid pBMB0231, complete sequence	103864-103899	6	0.833
NZ_AP022557_25	25.17\|3266419\|34\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3266419-3266452	34	NZ_CP031220	Arcobacter mytili LMG 24559 plasmid pAMYT, complete sequence	34446-34479	7	0.794
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH271319	Rhodococcus UhSalsa, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	KX712236	Rhodococcus phage Yogi, complete genome	15985-16014	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MF373842	Rhodococcus phage Jester, complete genome	15955-15984	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MF324902	Rhodococcus phage Krishelle, complete genome	16282-16311	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	KY549153	Rhodococcus phage AngryOrchard, complete genome	15930-15959	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MN945902	Rhodococcus phage Dinger, complete genome	15981-16010	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	KT959213	Rhodococcus phage TWAMP, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	KX611788	Rhodococcus phage Harlequin, complete genome	15961-15990	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH271297	Rhodococcus phage Erik, complete genome	16010-16039	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH271309	Rhodococcus phage Phrankenstein, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MF324898	Rhodococcus phage Hiro, complete genome	16267-16296	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MF324904	Rhodococcus phage RexFury, complete genome	16042-16071	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MF324901	Rhodococcus phage Naiad, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	KT990218	Rhodococcus phage Lillie, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	KX550082	Rhodococcus phage Natosaleda, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MK524495	Rhodococcus phage Belenaria, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MF189179	Rhodococcus phage Yoncess, complete genome	15985-16014	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	KY549154	Rhodococcus phage BobbyDazzler, complete genome	16056-16085	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH271299	Rhodococcus phage Gollum, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MF537628	Rhodococcus phage Bonanza, complete genome	15985-16014	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH271293	Rhodococcus phage Bradshaw, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	NC_028677	Rhodococcus phage CosmicSans, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH271306	Rhodococcus phage Nancinator, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH271311	Rhodococcus phage Rasputin, complete genome	15979-16008	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH271314	Rhodococcus phage Swann, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH271294	Rhodococcus phage Bryce, complete genome	15985-16014	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MF324900	Rhodococcus phage StCroix, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH271315	Rhodococcus phage Takoda, complete genome	15971-16000	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MH316569	Rhodococcus phage Shuman, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	KT375356	Rhodococcus phage Rhodalysa, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MK524487	Rhodococcus phage Espica, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MF324903	Rhodococcus phage AppleCloud, complete genome	15976-16005	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	KX712237	Rhodococcus phage Partridge, complete genome	16044-16073	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	NC_016653	Rhodococcus phage RER2, complete genome	12883-12912	7	0.767
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	MF324905	Rhodococcus phage Alatin, complete genome	16011-16040	7	0.767
NZ_AP022557_26	26.3\|3268512\|30\|NZ_AP022557\|PILER-CR,CRT	3268512-3268541	30	NZ_CP033935	Chryseobacterium balustinum strain KC_1863 plasmid unnamed, complete sequence	65804-65833	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP013615	Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence	8947-8976	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_AP014816	Geminocystis sp. NIES-3708 plasmid pGM01, complete sequence	43800-43829	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	LR214964	Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 10	53068-53097	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MG727701	Paenibacillus phage Leyra, complete genome	39262-39291	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	AP013399	Uncultured Mediterranean phage uvMED DNA, complete genome, group G15, isolate: uvMED-CGR-U-MedDCM-OCT-S40-C42	22860-22889	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_048689	Paenibacillus phage PBL1c, complete genome	37624-37653	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	AJ560763	Bacteriophage Aaphi23 complete genome	27437-27466	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_004827	Bacteriophage Aaphi23, complete genome	27437-27466	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	KP296795	Bacteriophage Shelly, complete genome	38138-38167	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	KT361652	Paenibacillus phage Xenia, complete genome	38135-38164	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	KP296792	Bacteriophage Lily, complete genome	42593-42622	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MG727702	Paenibacillus phage Likha, complete genome	36764-36793	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_014389	Butyrivibrio proteoclasticus B316 plasmid pCY360, complete sequence	216338-216367	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_012088	Onion yellows phytoplasma plasmid EcOYW1, complete sequence	4487-4516	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP017468	Staphylococcus nepalensis strain JS11 plasmid pSNJS1102, complete sequence	8642-8671	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_013373	Staphylococcus sp. CDC3 plasmid SAP020A, complete sequence	501-530	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	GQ866233	Aggregatibacter phage S1249, complete sequence	15566-15595	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP020426	Clostridioides difficile strain FDAARGOS_267 plasmid unnamed2, complete sequence	113634-113663	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP029155	Clostridioides difficile strain CD161 plasmid unnamed1, complete sequence	61234-61263	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP020479	Campylobacter helveticus strain ATCC 51209 plasmid pHELV-1, complete sequence	40133-40162	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448767	Streptococcus phage Javan467, complete genome	15758-15787	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448771	Streptococcus phage Javan481, complete genome	15472-15501	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448858	Streptococcus phage Javan166, complete genome	23087-23116	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK449012	Streptococcus phage Javan94, complete genome	17212-17241	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_004586	Streptococcus pyogenes phage 315.3, complete genome	15863-15892	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448969	Streptococcus phage Javan514, complete genome	17194-17223	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448943	Streptococcus phage Javan450, complete genome	15758-15787	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	CP011970	Peptoclostridium phage phiCDIF1296T strain DSM 1296, complete sequence	8337-8366	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448763	Streptococcus phage Javan451, complete genome	15888-15917	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MN694265	Marine virus AFVG_250M803, complete genome	14817-14846	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448945	Streptococcus phage Javan454, complete genome	20238-20267	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448786	Streptococcus phage Javan509, complete genome	15758-15787	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448774	Streptococcus phage Javan487, complete genome	14308-14337	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448963	Streptococcus phage Javan498, complete genome	11380-11409	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448773	Streptococcus phage Javan485, complete genome	17194-17223	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK448777	Streptococcus phage Javan491, complete genome	15770-15799	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	LN681537	Clostridium phage phiCD211, complete genome	17199-17228	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP037749	Campylobacter helveticus strain 2013D-9613 plasmid unnamed1	26732-26761	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MK496710	Capybara microvirus Cap1_SP_115, complete genome	3988-4017	7	0.767
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MN524844	Bacillus phage vB_Bpu_PumA1, complete genome	3174-3203	7	0.767
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP031072	Bacillus mycoides strain BPN401 plasmid pl395, complete sequence	206088-206123	7	0.806
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NC_022882	Bacillus thuringiensis YBT-1518 plasmid pBMB0233, complete sequence	194879-194914	7	0.806
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP011156	Bacillus cereus strain HN001 plasmid pRML01, complete sequence	27089-27124	7	0.806
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	CP037991	Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence	384877-384912	7	0.806
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	CP024685	Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence	195295-195330	7	0.806
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	CP024685	Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence	341458-341493	7	0.806
NZ_AP022557_31	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	30690-30735	7	0.848
NZ_AP022557_24	24.3\|3252976\|35\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3252976-3253010	35	NZ_AP022559	Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence	31799-31833	8	0.771
NZ_AP022557_26	26.1\|3268380\|30\|NZ_AP022557\|PILER-CR,CRT	3268380-3268409	30	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	47930-47959	8	0.733
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	NZ_CP015065	Mesorhizobium ciceri biovar biserrulae strain WSM1284 plasmid pMc1284, complete sequence	86023-86052	8	0.733
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	NZ_CP015063	Mesorhizobium ciceri strain CC1192 plasmid pMc1192, complete sequence	108971-109000	8	0.733
NZ_AP022557_26	26.2\|3268446\|30\|NZ_AP022557\|PILER-CR,CRT	3268446-3268475	30	NZ_CP053984	Achromobacter pestifer strain FDAARGOS_790 plasmid unnamed, complete sequence	63230-63259	8	0.733
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_018685	Bacillus thuringiensis MC28 plasmid pMC95, complete sequence	2964-2993	8	0.733
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_018686	Bacillus thuringiensis MC28 plasmid pMC183, complete sequence	144628-144657	8	0.733
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP020460	Lactobacillus sakei strain FAM18311 plasmid pFAM18311_1	68295-68324	8	0.733
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NZ_CP021678	Bacillus licheniformis strain SRCM100027 plasmid pBL027-1 sequence	19128-19157	8	0.733
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	AP014293	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S25-C61, * SEQUENCING IN PROGRESS *	6239-6268	8	0.733
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	KX507046	Vibrio phage S4-7, complete genome	61563-61592	8	0.733
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MH238467	Pasteurella phage Pm86, complete genome	3583-3612	8	0.733
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	GU943020	Uncultured phage MedDCM-OCT-S04-C64 genomic sequence	9629-9658	8	0.733
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	AP013451	Uncultured Mediterranean phage uvMED DNA, complete genome, group G17, isolate: uvMED-CGR-C66A-MedDCM-OCT-S40-C72	3452-3481	8	0.733
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	CP024685	Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence	43083-43118	8	0.778
NZ_AP022557_28	28.1\|3354703\|34\|NZ_AP022557\|CRISPRCasFinder,CRT	3354703-3354736	34	KR052482	Sinorhizobium phage phiN3, complete genome	144881-144914	8	0.765
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	JN654439	Bacillus phage BPS13, complete genome	9478-9512	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	HM144387	Bacillus phage W.Ph., complete genome	151538-151572	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NC_031034	Bacillus phage SalinJah, complete genome	21630-21664	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NZ_KY290886	Enterococcus faecalis strain Transconjugant T4 plasmid pJH-T4, complete sequence	75439-75473	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NZ_CP014451	Enterococcus faecium strain ATCC 700221 plasmid unnamed2, complete sequence	14731-14765	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NZ_LR135299	Enterococcus faecium isolate E7429 plasmid 3	20860-20894	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NZ_LR135341	Enterococcus faecium isolate E7356 plasmid 3	51594-51628	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NZ_CP027515	Enterococcus faecium strain AUSMDU00004028 plasmid unnamed3, complete sequence	31113-31147	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NZ_CP041255	Enterococcus faecium strain 515 plasmid p32, complete sequence	35787-35821	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NC_011364	Enterococcus faecium plasmid pMG1, complete sequence	45424-45458	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NZ_CP014535	Enterococcus faecium strain E745 plasmid pl6, complete sequence	46935-46969	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NC_007594	Enterococcus faecium plasmid pHT beta, complete sequence	34890-34924	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NZ_CP019972	Enterococcus faecium isolate 2014-VREF-114 plasmid p114-2 sequence	43538-43572	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NZ_CP018130	Enterococcus faecium strain A_020709_82 plasmid unnamed2, complete sequence	55869-55903	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	MN871481	UNVERIFIED: Pseudomonas phage PaSz-1_45_92k, complete genome	86879-86913	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	LN610586	Pseudomonas phage vB_PaeM_C2-10_Ab10, complete genome	82856-82890	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	LN610572	Pseudomonas phage vB_PaeM_C2-10_Ab02, complete genome	83269-83303	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	LN610587	Pseudomonas phage vB_PaeM_C2-10_Ab15, complete genome	82729-82763	8	0.771
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NC_019918	Pseudomonas phage vB_PaeM_C2-10_Ab1 complete genome	82210-82244	8	0.771
NZ_AP022557_24	24.23\|3254298\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3254298-3254333	36	NZ_CP045289	Curtobacterium flaccumfaciens pv. flaccumfaciens strain P990 plasmid pCff2, complete sequence	5164-5199	9	0.75
NZ_AP022557_25	25.17\|3266419\|34\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3266419-3266452	34	KT895374	Bacillus phage vB_BpuM-BpSp, complete genome	214043-214076	9	0.735
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	MN693963	Marine virus AFVG_250M975, complete genome	31702-31731	9	0.7
NZ_AP022557_26	26.4\|3268578\|30\|NZ_AP022557\|PILER-CR,CRT	3268578-3268607	30	NC_016969	Lactococcus garvieae 21881 plasmid pGL1 complete sequence	3614-3643	9	0.7
NZ_AP022557_27	27.7\|3352557\|36\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3352557-3352592	36	NZ_CP031069	Bacillus sp. JAS24-2 plasmid pl626, complete sequence	155587-155622	9	0.75
NZ_AP022557_28	28.20\|3355953\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3355953-3355987	35	NZ_CP025613	Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence	990756-990790	9	0.743
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	MN694628	Marine virus AFVG_250M527, complete genome	52173-52207	9	0.743
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	KU847400	UNVERIFIED: Bacillus phage Crookii, complete genome	150059-150093	9	0.743
NZ_AP022557_24	24.31\|3254827\|35\|NZ_AP022557\|PILER-CR,CRISPRCasFinder,CRT	3254827-3254861	35	MN311487	Antarctic microvirus CAA_003_V_1, complete genome	2590-2624	10	0.714
NZ_AP022557_28	28.9\|3355230\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3355230-3355264	35	NZ_CP021125	Rhizobium sp. Kim5 plasmid pRetKim5a, complete sequence	313086-313120	10	0.714
NZ_AP022557_28	28.9\|3355230\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3355230-3355264	35	CP007643	Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803b, complete sequence	377688-377722	10	0.714
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	NZ_CP042838	Enterococcus sp. DA9 plasmid unnamed3	14480-14514	10	0.714
NZ_AP022557_35	35.1\|3606973\|44\|NZ_AP022557\|CRISPRCasFinder	3606973-3607016	44	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	30724-30767	10	0.773
NZ_AP022557_28	28.10\|3355295\|34\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3355295-3355328	34	MN694028	Marine virus AFVG_250M137, complete genome	20195-20228	11	0.676
NZ_AP022557_28	28.21\|3356018\|35\|NZ_AP022557\|CRISPRCasFinder,CRT,PILER-CR	3356018-3356052	35	MN694494	Marine virus AFVG_250M305, complete genome	19430-19464	11	0.686

1. spacer 23.1|3241845|38|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to AB823818 (Phage phi OH2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

atgtgtaggaggtaatgaacaatgccaattaactatgc	CRISPR spacer
atgtgtaggaggtaatgaacaatgccaattaactatgc	Protospacer
**************************************

2. spacer 23.6|3242178|39|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_009737 (Bacillus virus 1, complete genome) position: , mismatch: 0, identity: 1.0

ttcattcacgaagggcgataccacattgtcgaggttgac	CRISPR spacer
ttcattcacgaagggcgataccacattgtcgaggttgac	Protospacer
***************************************

3. spacer 24.8|3253307|39|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_009737 (Bacillus virus 1, complete genome) position: , mismatch: 0, identity: 1.0

ttcattcacgaagggcgataccacattgtcgaggttgac	CRISPR spacer
ttcattcacgaagggcgataccacattgtcgaggttgac	Protospacer
***************************************

4. spacer 24.35|3255092|37|NZ_AP022557|CRISPRCasFinder,CRT matches to NZ_AP022559 (Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence) position: , mismatch: 0, identity: 1.0

aatacatcgccgtgcgggcgcggaaggtggcgtagtc	CRISPR spacer
aatacatcgccgtgcgggcgcggaaggtggcgtagtc	Protospacer
*************************************

5. spacer 25.28|3267144|37|NZ_AP022557|CRISPRCasFinder,CRT matches to NZ_AP022559 (Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence) position: , mismatch: 0, identity: 1.0

aatacatcgccgtgcgggcgcggaaggtggcgtagtc	CRISPR spacer
aatacatcgccgtgcgggcgcggaaggtggcgtagtc	Protospacer
*************************************

6. spacer 26.3|3268512|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP020031 (Geobacillus thermodenitrificans strain T12 plasmid pGeo12a, complete sequence) position: , mismatch: 0, identity: 1.0

aacaggcttctcaggatgttgaacgtatcg	CRISPR spacer
aacaggcttctcaggatgttgaacgtatcg	Protospacer
******************************

7. spacer 26.3|3268512|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP020032 (Geobacillus thermodenitrificans strain T12 plasmid pGeo12b, complete sequence) position: , mismatch: 0, identity: 1.0

aacaggcttctcaggatgttgaacgtatcg	CRISPR spacer
aacaggcttctcaggatgttgaacgtatcg	Protospacer
******************************

8. spacer 26.3|3268512|30|NZ_AP022557|PILER-CR,CRT matches to NC_009329 (Geobacillus thermodenitrificans NG80-2 plasmid pLW1071, complete sequence) position: , mismatch: 0, identity: 1.0

aacaggcttctcaggatgttgaacgtatcg	CRISPR spacer
aacaggcttctcaggatgttgaacgtatcg	Protospacer
******************************

9. spacer 26.3|3268512|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP016918 (Parageobacillus thermoglucosidasius strain TM242 plasmid pNCI002, complete sequence) position: , mismatch: 0, identity: 1.0

aacaggcttctcaggatgttgaacgtatcg	CRISPR spacer
aacaggcttctcaggatgttgaacgtatcg	Protospacer
******************************

10. spacer 26.3|3268512|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP049704 (Parageobacillus toebii NBRC 107807 strain DSM 14590 plasmid pDSM14590, complete sequence) position: , mismatch: 0, identity: 1.0

aacaggcttctcaggatgttgaacgtatcg	CRISPR spacer
aacaggcttctcaggatgttgaacgtatcg	Protospacer
******************************

11. spacer 26.3|3268512|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP017691 (Geobacillus thermodenitrificans strain ID-1 plasmid pLDW-2, complete sequence) position: , mismatch: 0, identity: 1.0

aacaggcttctcaggatgttgaacgtatcg	CRISPR spacer
aacaggcttctcaggatgttgaacgtatcg	Protospacer
******************************

12. spacer 26.3|3268512|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP016624 (Parageobacillus thermoglucosidasius strain Wild Type plasmid pNCI002, complete sequence) position: , mismatch: 0, identity: 1.0

aacaggcttctcaggatgttgaacgtatcg	CRISPR spacer
aacaggcttctcaggatgttgaacgtatcg	Protospacer
******************************

13. spacer 26.3|3268512|30|NZ_AP022557|PILER-CR,CRT matches to NC_010420 (Geobacillus stearothermophilus plasmid pGS18, strain 18) position: , mismatch: 0, identity: 1.0

aacaggcttctcaggatgttgaacgtatcg	CRISPR spacer
aacaggcttctcaggatgttgaacgtatcg	Protospacer
******************************

14. spacer 28.9|3355230|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to AB823818 (Phage phi OH2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ccaacatcgcatcgaacattggcgcttttcctgtc	CRISPR spacer
ccaacatcgcatcgaacattggcgcttttcctgtc	Protospacer
***********************************

15. spacer 23.2|3241913|35|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015439 (Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence) position: , mismatch: 1, identity: 0.971

atatctacaaatatctgatgttcgcatatcgagcg	CRISPR spacer
atatctacaaatatccgatgttcgcatatcgagcg	Protospacer
***************.*******************

16. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MH617573 (Microviridae sp. isolate ctbf823, complete genome) position: , mismatch: 3, identity: 0.9

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
ataaaacaaaagaagaatgcgaaaaagaat	Protospacer
* * **************.***********

17. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP014451 (Enterococcus faecium strain ATCC 700221 plasmid unnamed2, complete sequence) position: , mismatch: 3, identity: 0.9

-aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagtaa-aaaagaagaatatgaaaaagaat	Protospacer
 **.*** ************.**********

18. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_LR135341 (Enterococcus faecium isolate E7356 plasmid 3) position: , mismatch: 3, identity: 0.9

-aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagtaa-aaaagaagaatatgaaaaagaat	Protospacer
 **.*** ************.**********

19. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_011364 (Enterococcus faecium plasmid pMG1, complete sequence) position: , mismatch: 3, identity: 0.9

-aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagtaa-aaaagaagaatatgaaaaagaat	Protospacer
 **.*** ************.**********

20. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP014535 (Enterococcus faecium strain E745 plasmid pl6, complete sequence) position: , mismatch: 3, identity: 0.9

-aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagtaa-aaaagaagaatatgaaaaagaat	Protospacer
 **.*** ************.**********

21. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_007594 (Enterococcus faecium plasmid pHT beta, complete sequence) position: , mismatch: 3, identity: 0.9

-aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagtaa-aaaagaagaatatgaaaaagaat	Protospacer
 **.*** ************.**********

22. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP019972 (Enterococcus faecium isolate 2014-VREF-114 plasmid p114-2 sequence) position: , mismatch: 3, identity: 0.9

-aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagtaa-aaaagaagaatatgaaaaagaat	Protospacer
 **.*** ************.**********

23. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP018130 (Enterococcus faecium strain A_020709_82 plasmid unnamed2, complete sequence) position: , mismatch: 3, identity: 0.9

-aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagtaa-aaaagaagaatatgaaaaagaat	Protospacer
 **.*** ************.**********

24. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_LR135299 (Enterococcus faecium isolate E7429 plasmid 3) position: , mismatch: 3, identity: 0.9

-aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagtaa-aaaagaagaatatgaaaaagaat	Protospacer
 **.*** ************.**********

25. spacer 27.1|3352159|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015439 (Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence) position: , mismatch: 3, identity: 0.917

cgcacatattgctctccaccgttttcattggcgtcc	CRISPR spacer
tgcgcatgttgctctccaccgttttcattggcgtcc	Protospacer
.**.***.****************************

26. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_007103 (Bacillus cereus E33L plasmid pE33L466, complete sequence) position: , mismatch: 4, identity: 0.889

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctatca-	Protospacer
******.** ********************.* ***

27. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_007103 (Bacillus cereus E33L plasmid pE33L466, complete sequence) position: , mismatch: 4, identity: 0.889

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctatca-	Protospacer
******.** ********************.* ***

28. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009967 (Bacillus cereus E33L plasmid pBCO_1, complete sequence) position: , mismatch: 4, identity: 0.889

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctatca-	Protospacer
******.** ********************.* ***

29. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009967 (Bacillus cereus E33L plasmid pBCO_1, complete sequence) position: , mismatch: 4, identity: 0.889

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctatca-	Protospacer
******.** ********************.* ***

30. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015592 (Bacillus cereus strain AR156 plasmid pAR460, complete sequence) position: , mismatch: 4, identity: 0.889

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctatca-	Protospacer
******.** ********************.* ***

31. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009368 (Bacillus cereus strain FM1 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.889

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctatca-	Protospacer
******.** ********************.* ***

32. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009368 (Bacillus cereus strain FM1 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.889

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctatca-	Protospacer
******.** ********************.* ***

33. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009336 (Bacillus thuringiensis strain HD1011 plasmid 1, complete sequence) position: , mismatch: 4, identity: 0.889

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctatca-	Protospacer
******.** ********************.* ***

34. spacer 23.2|3241913|35|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to AB823818 (Phage phi OH2 DNA, complete genome) position: , mismatch: 5, identity: 0.857

atatctacaaatatctgatgttcgcatatcgagcg	CRISPR spacer
gcttctacaaatatccgatgtccgcatatcgagcg	Protospacer
.. ************.*****.*************

35. spacer 26.5|3268644|30|NZ_AP022557|PILER-CR,CRT matches to KY385423 (Klebsiella phage vB_KpnP_KpV74, complete genome) position: , mismatch: 5, identity: 0.833

gatgatga-tttatactcccccggcaagaaa	CRISPR spacer
-acgataagtttatactcccccgggaagaag	Protospacer
 *.***.* *************** *****.

36. spacer 26.5|3268644|30|NZ_AP022557|PILER-CR,CRT matches to KX211991 (Klebsiella phage vB_KpnP_KpV475, complete genome) position: , mismatch: 5, identity: 0.833

gatgatga-tttatactcccccggcaagaaa	CRISPR spacer
-acgataagtttatactcccccgggaagaag	Protospacer
 *.***.* *************** *****.

37. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_010180 (Bacillus mycoides KBAB4 plasmid pBWB401, complete sequence) position: , mismatch: 5, identity: 0.861

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacttaccg	Protospacer
******.** ********************** *

38. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015592 (Bacillus cereus strain AR156 plasmid pAR460, complete sequence) position: , mismatch: 5, identity: 0.861

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
agctatgccaaaccgaaattcatctcccacctatca-	Protospacer
.*****.** ********************.* ***

39. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009368 (Bacillus cereus strain FM1 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.861

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccccctatca-	Protospacer
******.** ****************** *.* ***

40. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009368 (Bacillus cereus strain FM1 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.861

ggctatacctaaccgaaattcatctcccactt-tcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccccctatca-	Protospacer
******.** ****************** *.* ***

41. spacer 12.1|1424425|33|NZ_AP022557|CRISPRCasFinder matches to NZ_CP051164 (Geobacillus subterraneus strain CPW16 plasmid pBsrF30, complete sequence) position: , mismatch: 6, identity: 0.818

agctaacccaaaagattgcctgccttcaagatc	CRISPR spacer
ggccgacccaaaaggtcgcctgccttcaagata	Protospacer
.**..*********.*.***************

42. spacer 25.17|3266419|34|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to MT774386 (CrAssphage cr110_1, complete genome) position: , mismatch: 6, identity: 0.824

ataccgta-tgttcttgaagaagtttttgattttc	CRISPR spacer
-tatcttgctgttcttgaagaagttttttatattc	Protospacer
 **.* *. ******************* ** ***

43. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP031066 (Bacillus sp. SH8-8 plasmid pl193, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

44. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP004874 (Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB74, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

45. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP015154 (Bacillus thuringiensis strain Bc601 plasmid pBTBC4, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

46. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP013059 (Bacillus thuringiensis strain YWC2-8 plasmid pYWC2-8-4, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

47. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to CP024687 (Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-3-257K, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

48. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_018686 (Bacillus thuringiensis MC28 plasmid pMC183, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

49. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP031063 (Bacillus sp. AR4-2 plasmid pl192, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

50. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP018742 (Bacillus cereus strain FORC_047 plasmid pFORC47_2, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

51. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_MG710485 (Bacillus thuringiensis serovar israelensis strain Bti-UFT6.51 plasmid pBtiUFT6.51.1 complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

52. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP046399 (Bacillus sp. A260 plasmid unnamed11, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

53. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP011351 (Bacillus thuringiensis strain YC-10 plasmid pYC3, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

54. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP015180 (Bacillus thuringiensis serovar alesti strain BGSC 4C1 plasmid pBMB71, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

55. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP020746 (Bacillus mycoides strain Gnyt1 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

56. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_020240 (Bacillus thuringiensis serovar kurstaki str. HD73 plasmid pAW63, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacaacaaaagaagaataccaaaagatat	Protospacer
.**.**************** ****.. **

57. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to AP014409 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C28-MedDCM-OCT-S37-C188, *** SEQUENCING IN PROGRESS ***, 6 ordered pieces) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aaggcactaaagaagaatatgaaaaagaac	Protospacer
**.  ** ***********.*********.

58. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to HQ670749 (Cellulophaga phage phi47:1, *** SEQUENCING IN PROGRESS ***, 6 unordered pieces) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
agaaaacaaaagaacaatacgaaaaaaacc	Protospacer
*.* ********** ***********.* .

59. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_KY290886 (Enterococcus faecalis strain Transconjugant T4 plasmid pJH-T4, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagcaaaaaagaagaatatgaaaaagagt	Protospacer
 **  * ************.********.*

60. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP027515 (Enterococcus faecium strain AUSMDU00004028 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagcaaaaaagaagaatatgaaaaagagt	Protospacer
 **  * ************.********.*

61. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aagaaacaaaagaagtatatgaaaaaggaa	Protospacer
**. *********** ***.*******.*

62. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_022875 (Bacillus thuringiensis YBT-1518 plasmid pBMB0230, complete sequence) position: , mismatch: 6, identity: 0.8

-aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gtcatga-aaaagaagaaaaagaaaaagaat	Protospacer
   **.* ********** * **********

63. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aagaaacaaaagaagtatatgaaaaaggaa	Protospacer
**. *********** ***.*******.*

64. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP041255 (Enterococcus faecium strain 515 plasmid p32, complete sequence) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
taagcaaaaaagaagaatatgaaaaagagt	Protospacer
 **  * ************.********.*

65. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MT500540 (Listeria phage LP-HM00113468, complete genome) position: , mismatch: 6, identity: 0.8

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aagaaacaaaagaagtatatgaaaaaggaa	Protospacer
**. *********** ***.*******.*

66. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_010180 (Bacillus mycoides KBAB4 plasmid pBWB401, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

67. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015355 (Bacillus thuringiensis strain MYBT18246 plasmid p109822, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctataccaaatcgaaattcatctcccacctaccg	Protospacer
********* **.*****************.* *

68. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031072 (Bacillus mycoides strain BPN401 plasmid pl395, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

69. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031072 (Bacillus mycoides strain BPN401 plasmid pl395, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

70. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031072 (Bacillus mycoides strain BPN401 plasmid pl395, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

71. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020744 (Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctacaccaaaccgaaattcatctcccacctaccg	Protospacer
*****.*** ********************.* *

72. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020744 (Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

73. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020744 (Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

74. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020744 (Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctacaccaaaccgaaattcatctcccacctaccg	Protospacer
*****.*** ********************.* *

75. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020744 (Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

76. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020744 (Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctacaccaaaccgaaattcatctcccacctaccg	Protospacer
*****.*** ********************.* *

77. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020744 (Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

78. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020744 (Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctacaccaaaccgaaattcatctcccacctaccg	Protospacer
*****.*** ********************.* *

79. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009691 (Bacillus mycoides strain ATCC 6462 plasmid pBMX_1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

80. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_022882 (Bacillus thuringiensis YBT-1518 plasmid pBMB0233, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

81. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_022874 (Bacillus thuringiensis YBT-1518 plasmid pBMB0229, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

82. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_022874 (Bacillus thuringiensis YBT-1518 plasmid pBMB0229, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

83. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to CP037991 (Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

84. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to CP037991 (Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

85. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to CP037991 (Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

86. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to CP037991 (Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

87. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to CP037991 (Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

88. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_022876 (Bacillus thuringiensis YBT-1518 plasmid pBMB0231, complete sequence) position: , mismatch: 6, identity: 0.833

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctaccg	Protospacer
******.** ********************.* *

89. spacer 25.17|3266419|34|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031220 (Arcobacter mytili LMG 24559 plasmid pAMYT, complete sequence) position: , mismatch: 7, identity: 0.794

ataccgtatgttcttgaagaagtttttgattttc	CRISPR spacer
aaatcataattttttgaagaagtttttgcttttc	Protospacer
* *.*.**  **.*************** *****

90. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH271319 (Rhodococcus UhSalsa, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

91. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to KX712236 (Rhodococcus phage Yogi, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

92. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MF373842 (Rhodococcus phage Jester, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

93. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MF324902 (Rhodococcus phage Krishelle, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

94. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to KY549153 (Rhodococcus phage AngryOrchard, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

95. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MN945902 (Rhodococcus phage Dinger, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

96. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to KT959213 (Rhodococcus phage TWAMP, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

97. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to KX611788 (Rhodococcus phage Harlequin, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

98. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH271297 (Rhodococcus phage Erik, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

99. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH271309 (Rhodococcus phage Phrankenstein, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

100. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MF324898 (Rhodococcus phage Hiro, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

101. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MF324904 (Rhodococcus phage RexFury, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

102. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MF324901 (Rhodococcus phage Naiad, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

103. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to KT990218 (Rhodococcus phage Lillie, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

104. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to KX550082 (Rhodococcus phage Natosaleda, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

105. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MK524495 (Rhodococcus phage Belenaria, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

106. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MF189179 (Rhodococcus phage Yoncess, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

107. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to KY549154 (Rhodococcus phage BobbyDazzler, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

108. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH271299 (Rhodococcus phage Gollum, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

109. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MF537628 (Rhodococcus phage Bonanza, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

110. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH271293 (Rhodococcus phage Bradshaw, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

111. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to NC_028677 (Rhodococcus phage CosmicSans, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

112. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH271306 (Rhodococcus phage Nancinator, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

113. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH271311 (Rhodococcus phage Rasputin, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

114. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH271314 (Rhodococcus phage Swann, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

115. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH271294 (Rhodococcus phage Bryce, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

116. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MF324900 (Rhodococcus phage StCroix, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

117. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH271315 (Rhodococcus phage Takoda, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

118. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MH316569 (Rhodococcus phage Shuman, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

119. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to KT375356 (Rhodococcus phage Rhodalysa, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

120. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MK524487 (Rhodococcus phage Espica, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

121. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MF324903 (Rhodococcus phage AppleCloud, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

122. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to KX712237 (Rhodococcus phage Partridge, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

123. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to NC_016653 (Rhodococcus phage RER2, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

124. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to MF324905 (Rhodococcus phage Alatin, complete genome) position: , mismatch: 7, identity: 0.767

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
ccgatctggccggaatgggttgccactgcc	Protospacer
  .  ********* ********** ****

125. spacer 26.3|3268512|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP033935 (Chryseobacterium balustinum strain KC_1863 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

aacaggcttctcaggatgttgaacgtatcg	CRISPR spacer
tatacttttctcgggatgttgaatgtatcg	Protospacer
 *.*  .*****.**********.******

126. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP013615 (Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
cattaacaaaagaagaatatgaaaatttaa	Protospacer
 * ****************.*****   *

127. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_AP014816 (Geminocystis sp. NIES-3708 plasmid pGM01, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atataacaaaagaagaatttgaaaaatgtg	Protospacer
* **************** .****** .

128. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to LR214964 (Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 10) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
ttataacaaaagaagaatttgaaaaacaca	Protospacer
  **************** .****** *

129. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MG727701 (Paenibacillus phage Leyra, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gatttgaaaaggaagaatacgaaaaagaaa	Protospacer
.* * . ***.******************

130. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to AP013399 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G15, isolate: uvMED-CGR-U-MedDCM-OCT-S40-C42) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat-----	CRISPR spacer
aaattacaaaagaaaaatacga-----aatctttg	Protospacer
**** *********.*******     ***

131. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_048689 (Paenibacillus phage PBL1c, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gatttgaaaaggaagaatacgaaaaagaaa	Protospacer
.* * . ***.******************

132. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to AJ560763 (Bacteriophage Aaphi23 complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
acgtggacaaagaagaatacgaaaaaaaat	Protospacer
* .*..  ******************.***

133. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_004827 (Bacteriophage Aaphi23, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
acgtggacaaagaagaatacgaaaaaaaat	Protospacer
* .*..  ******************.***

134. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to KP296795 (Bacteriophage Shelly, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gatttgaaaaggaagaatacgaaaaagaaa	Protospacer
.* * . ***.******************

135. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to KT361652 (Paenibacillus phage Xenia, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gatttgaaaaggaagaatacgaaaaagaaa	Protospacer
.* * . ***.******************

136. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to KP296792 (Bacteriophage Lily, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gatttgaaaaggaagaatacgaaaaagaaa	Protospacer
.* * . ***.******************

137. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MG727702 (Paenibacillus phage Likha, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gatttgaaaaggaagaatacgaaaaagaaa	Protospacer
.* * . ***.******************

138. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_014389 (Butyrivibrio proteoclasticus B316 plasmid pCY360, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atcttcggaaagaagaataagaaaaagaat	Protospacer
*  *   .*********** **********

139. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_012088 (Onion yellows phytoplasma plasmid EcOYW1, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
tatcagtaaaagaagaatacaaaaaagaag	Protospacer
 * .*..*************.********

140. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP017468 (Staphylococcus nepalensis strain JS11 plasmid pSNJS1102, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gaacatcaaaagaagaatacgaaaagaata	Protospacer
.**.* *******************..*

141. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_013373 (Staphylococcus sp. CDC3 plasmid SAP020A, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gattaacaaaagaagaatatgaaaatttaa	Protospacer
.* ****************.*****   *

142. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to GQ866233 (Aggregatibacter phage S1249, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
acgtggacaaagaagaatacgaaaaaaaat	Protospacer
* .*..  ******************.***

143. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP020426 (Clostridioides difficile strain FDAARGOS_267 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aagatacaaaagaagaatacgaattagata	Protospacer
**.  ******************  ***

144. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP029155 (Clostridioides difficile strain CD161 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aagatacaaaagaagaatacgaattagata	Protospacer
**.  ******************  ***

145. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP020479 (Campylobacter helveticus strain ATCC 51209 plasmid pHELV-1, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
ataaggaaaacgaagaatatgaaaaagaat	Protospacer
* * .. *** ********.**********

146. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448767 (Streptococcus phage Javan467, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

147. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448771 (Streptococcus phage Javan481, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

148. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448858 (Streptococcus phage Javan166, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

149. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK449012 (Streptococcus phage Javan94, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

150. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_004586 (Streptococcus pyogenes phage 315.3, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

151. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448969 (Streptococcus phage Javan514, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

152. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448943 (Streptococcus phage Javan450, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

153. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to CP011970 (Peptoclostridium phage phiCDIF1296T strain DSM 1296, complete sequence) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aagatacaaaagaagaatacgaattagata	Protospacer
**.  ******************  ***

154. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448763 (Streptococcus phage Javan451, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

155. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MN694265 (Marine virus AFVG_250M803, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aaataacaaaggaagaatacaaagagtggt	Protospacer
**********.*********.**.*. ..*

156. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448945 (Streptococcus phage Javan454, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
acgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

157. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448786 (Streptococcus phage Javan509, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

158. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448774 (Streptococcus phage Javan487, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

159. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448963 (Streptococcus phage Javan498, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

160. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448773 (Streptococcus phage Javan485, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

161. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK448777 (Streptococcus phage Javan491, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atgaaacaaaagaagcttacgaaaaagcct	Protospacer
* . ***********  **********  *

162. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to LN681537 (Clostridium phage phiCD211, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aagatacaaaagaagaatacgaattagata	Protospacer
**.  ******************  ***

163. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP037749 (Campylobacter helveticus strain 2013D-9613 plasmid unnamed1) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
ataaggaaaacgaagaatatgaaaaagaat	Protospacer
* * .. *** ********.**********

164. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MK496710 (Capybara microvirus Cap1_SP_115, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
catcagaaaaagaagaataagaaagagaat	Protospacer
 * .*. ************ ****.*****

165. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MN524844 (Bacillus phage vB_Bpu_PumA1, complete genome) position: , mismatch: 7, identity: 0.767

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aaattacaaaagaagaatacaaatacattt	Protospacer
**** ***************.** * .  *

166. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031072 (Bacillus mycoides strain BPN401 plasmid pl395, complete sequence) position: , mismatch: 7, identity: 0.806

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccatctaccg	Protospacer
******.** *******************..* *

167. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NC_022882 (Bacillus thuringiensis YBT-1518 plasmid pBMB0233, complete sequence) position: , mismatch: 7, identity: 0.806

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccccctaccg	Protospacer
******.** ****************** *.* *

168. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011156 (Bacillus cereus strain HN001 plasmid pRML01, complete sequence) position: , mismatch: 7, identity: 0.806

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
tgctatgccaaaccgaaattcatctcccacctaccg	Protospacer
 *****.** ********************.* *

169. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to CP037991 (Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.806

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
agctatgccaaaccgaaattcatctcccacctaccg	Protospacer
.*****.** ********************.* *

170. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to CP024685 (Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence) position: , mismatch: 7, identity: 0.806

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctatcg	Protospacer
******.** ********************.* .

171. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to CP024685 (Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence) position: , mismatch: 7, identity: 0.806

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
ggctatgccaaaccgaaattcatctcccacctatcg	Protospacer
******.** ********************.* .

172. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 7, identity: 0.848

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tgcgtcagtcctgcattttcacggaaaagatccatgggcagcgcgc	Protospacer
*.**.***********************************..*  .

173. spacer 24.3|3252976|35|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP022559 (Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence) position: , mismatch: 8, identity: 0.771

ctcccaaagttcttcctccttcacgcatatcgcca	CRISPR spacer
ctcatgatgttgttcctccttcacacatatcgctt	Protospacer
*** ..* *** ************.********.

174. spacer 26.1|3268380|30|NZ_AP022557|PILER-CR,CRT matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 8, identity: 0.733

aatgatggctacgactttgcgaatggatca	CRISPR spacer
ggcgttggctacgaccttgcgaatggcccg	Protospacer
...* **********.********** .*.

175. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP015065 (Mesorhizobium ciceri biovar biserrulae strain WSM1284 plasmid pMc1284, complete sequence) position: , mismatch: 8, identity: 0.733

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
caacgctggccgcattgggtcgccacctgg	Protospacer
 *********** *******.**** .

176. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP015063 (Mesorhizobium ciceri strain CC1192 plasmid pMc1192, complete sequence) position: , mismatch: 8, identity: 0.733

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
caacgctggccgcattgggtcgccacctgg	Protospacer
 *********** *******.**** .

177. spacer 26.2|3268446|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP053984 (Achromobacter pestifer strain FDAARGOS_790 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

gaacgctggccggattgggttgccagtgcc	CRISPR spacer
gcgacttggccggatcgggttgccagggct	Protospacer
* .  .*********.********** **.

178. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_018685 (Bacillus thuringiensis MC28 plasmid pMC95, complete sequence) position: , mismatch: 8, identity: 0.733

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
tccaaacaaaagaagtatacgaaaaggcaa	Protospacer
    *********** *********.* *

179. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_018686 (Bacillus thuringiensis MC28 plasmid pMC183, complete sequence) position: , mismatch: 8, identity: 0.733

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
tccaaacaaaagaagtatacgaaaaggcaa	Protospacer
    *********** *********.* *

180. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP020460 (Lactobacillus sakei strain FAM18311 plasmid pFAM18311_1) position: , mismatch: 8, identity: 0.733

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aaattacaaaagaagaatacgtcactaagc	Protospacer
**** ****************  *  .*..

181. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NZ_CP021678 (Bacillus licheniformis strain SRCM100027 plasmid pBL027-1 sequence) position: , mismatch: 8, identity: 0.733

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
atttaacaaaagaagaaaaagaaaaaatga	Protospacer
*  ************** * ******. .

182. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to AP014293 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S25-C61, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.733

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
ttgaaacagaagaagaatacgaaaagttat	Protospacer
  . ****.****************.  **

183. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to KX507046 (Vibrio phage S4-7, complete genome) position: , mismatch: 8, identity: 0.733

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aaatgaccaaagaagaatacgaagcactcc	Protospacer
****.** ***************. *   .

184. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MH238467 (Pasteurella phage Pm86, complete genome) position: , mismatch: 8, identity: 0.733

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
caatcacaaaagaagaatatgaaagtcttt	Protospacer
 *** **************.****.    *

185. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to GU943020 (Uncultured phage MedDCM-OCT-S04-C64 genomic sequence) position: , mismatch: 8, identity: 0.733

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aagaaacaaaagaaaaatacgaaaaccttg	Protospacer
**. **********.**********

186. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to AP013451 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G17, isolate: uvMED-CGR-C66A-MedDCM-OCT-S40-C72) position: , mismatch: 8, identity: 0.733

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
aagaaacaaaagaaaaatacgaaaaccttg	Protospacer
**. **********.**********

187. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to CP024685 (Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence) position: , mismatch: 8, identity: 0.778

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
gtttataccaaaccgaaatgcatctcccacctaccg	Protospacer
* .****** ********* **********.* *

188. spacer 28.1|3354703|34|NZ_AP022557|CRISPRCasFinder,CRT matches to KR052482 (Sinorhizobium phage phiN3, complete genome) position: , mismatch: 8, identity: 0.765

ttcctcctcaaaacaaaaaagacgggatttcccg	CRISPR spacer
tttgaaatgaaaacaaaaaagccggggtttcccg	Protospacer
**.    * ************ ****.*******

189. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to JN654439 (Bacillus phage BPS13, complete genome) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
ttctctctagccattttttatctcctttcttttgt	Protospacer
*   .  ********** *************** *

190. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to HM144387 (Bacillus phage W.Ph., complete genome) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
ttttctctagccattttttatctcctttcttttgt	Protospacer
*   .  ********** *************** *

191. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NC_031034 (Bacillus phage SalinJah, complete genome) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
ttctctctagccattttttatctcctttcttttgt	Protospacer
*   .  ********** *************** *

192. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_KY290886 (Enterococcus faecalis strain Transconjugant T4 plasmid pJH-T4, complete sequence) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

193. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP014451 (Enterococcus faecium strain ATCC 700221 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

194. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_LR135299 (Enterococcus faecium isolate E7429 plasmid 3) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

195. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_LR135341 (Enterococcus faecium isolate E7356 plasmid 3) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

196. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP027515 (Enterococcus faecium strain AUSMDU00004028 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

197. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP041255 (Enterococcus faecium strain 515 plasmid p32, complete sequence) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

198. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NC_011364 (Enterococcus faecium plasmid pMG1, complete sequence) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

199. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP014535 (Enterococcus faecium strain E745 plasmid pl6, complete sequence) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

200. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NC_007594 (Enterococcus faecium plasmid pHT beta, complete sequence) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

201. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP019972 (Enterococcus faecium isolate 2014-VREF-114 plasmid p114-2 sequence) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

202. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP018130 (Enterococcus faecium strain A_020709_82 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.771

taaataatagccattttatatctcctttctttttt	CRISPR spacer
tttttataggccatcttctatctcctttctttttt	Protospacer
*   **  .*****.** *****************

203. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to MN871481 (UNVERIFIED: Pseudomonas phage PaSz-1_45_92k, complete genome) position: , mismatch: 8, identity: 0.771

taaataata---gccattttatatctcctttctttttt	CRISPR spacer
---atagaacgtgccattttaaatctcctttctgttta	Protospacer
   ***. *   ********* *********** ***

204. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to LN610586 (Pseudomonas phage vB_PaeM_C2-10_Ab10, complete genome) position: , mismatch: 8, identity: 0.771

taaataata---gccattttatatctcctttctttttt	CRISPR spacer
---atagaacgtgccattttaaatctcctttctgttta	Protospacer
   ***. *   ********* *********** ***

205. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to LN610572 (Pseudomonas phage vB_PaeM_C2-10_Ab02, complete genome) position: , mismatch: 8, identity: 0.771

taaataata---gccattttatatctcctttctttttt	CRISPR spacer
---atagaacgtgccattttaaatctcctttctgttta	Protospacer
   ***. *   ********* *********** ***

206. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to LN610587 (Pseudomonas phage vB_PaeM_C2-10_Ab15, complete genome) position: , mismatch: 8, identity: 0.771

taaataata---gccattttatatctcctttctttttt	CRISPR spacer
---atagaacgtgccattttaaatctcctttctgttta	Protospacer
   ***. *   ********* *********** ***

207. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NC_019918 (Pseudomonas phage vB_PaeM_C2-10_Ab1 complete genome) position: , mismatch: 8, identity: 0.771

taaataata---gccattttatatctcctttctttttt	CRISPR spacer
---atagaacgtgccattttaaatctcctttctgttta	Protospacer
   ***. *   ********* *********** ***

208. spacer 24.23|3254298|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045289 (Curtobacterium flaccumfaciens pv. flaccumfaciens strain P990 plasmid pCff2, complete sequence) position: , mismatch: 9, identity: 0.75

tttattttcctccttttgttttttctaattatattg	CRISPR spacer
tttcttttcctccttttcttttttcttccttttctt	Protospacer
*** ************* ********  .* * .*

209. spacer 25.17|3266419|34|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to KT895374 (Bacillus phage vB_BpuM-BpSp, complete genome) position: , mismatch: 9, identity: 0.735

ataccgtatgttcttgaagaagtttttgattttc	CRISPR spacer
aatacaaatgttattgaagaagattttgattcta	Protospacer
*   *. ***** ********* ********.*

210. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to MN693963 (Marine virus AFVG_250M975, complete genome) position: , mismatch: 9, identity: 0.7

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
tggggagcaaagaagaatacgataaagaaa	Protospacer
 .. .*  ************** ******

211. spacer 26.4|3268578|30|NZ_AP022557|PILER-CR,CRT matches to NC_016969 (Lactococcus garvieae 21881 plasmid pGL1 complete sequence) position: , mismatch: 9, identity: 0.7

aaataacaaaagaagaatacgaaaaagaat	CRISPR spacer
gtaagcaaaaagaaaaatacgaaaaagaca	Protospacer
. * .  *******.*************

212. spacer 27.7|3352557|36|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031069 (Bacillus sp. JAS24-2 plasmid pl626, complete sequence) position: , mismatch: 9, identity: 0.75

ggctatacctaaccgaaattcatctcccactttcac	CRISPR spacer
gactatgccaaaccgaaattcatctcccgcctagcg	Protospacer
*.****.** ******************.*.*

213. spacer 28.20|3355953|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP025613 (Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.743

ataaaacgacgggtgcaacagttgatgcgggttcg	CRISPR spacer
gggccagcaagggtgcaacagttgatgggggttcg	Protospacer
. .  *  * ***************** *******

214. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to MN694628 (Marine virus AFVG_250M527, complete genome) position: , mismatch: 9, identity: 0.743

taaataatagccattttatatctcctttctttttt	CRISPR spacer
cccgttccagccattttatttctcctttatttttt	Protospacer
.  .*  .*********** ******** ******

215. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to KU847400 (UNVERIFIED: Bacillus phage Crookii, complete genome) position: , mismatch: 9, identity: 0.743

taaataatagccattttatatctcctttctttttt	CRISPR spacer
ttctctctagccatttcttatctcctttcttttgt	Protospacer
*   .  *********. *************** *

216. spacer 24.31|3254827|35|NZ_AP022557|PILER-CR,CRISPRCasFinder,CRT matches to MN311487 (Antarctic microvirus CAA_003_V_1, complete genome) position: , mismatch: 10, identity: 0.714

----attgtatgtgtttctgtttttttgctggtttttgt	CRISPR spacer
caaaat----cgtgtttttgtttttttgctgcttttgca	Protospacer
    **    .******.************* ****

217. spacer 28.9|3355230|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP021125 (Rhizobium sp. Kim5 plasmid pRetKim5a, complete sequence) position: , mismatch: 10, identity: 0.714

ccaacatcgcatcgaacattggcgcttttcctgtc	CRISPR spacer
ccaacatcgcatcggacgttggcgcggccgcctgc	Protospacer
**************.**.*******  .. *.  *

218. spacer 28.9|3355230|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to CP007643 (Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803b, complete sequence) position: , mismatch: 10, identity: 0.714

ccaacatcgcatcgaacattggcgcttttcctgtc	CRISPR spacer
ccaacatcgcatcggacgttggcgcggccgcctgc	Protospacer
**************.**.*******  .. *.  *

219. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP042838 (Enterococcus sp. DA9 plasmid unnamed3) position: , mismatch: 10, identity: 0.714

taaataatagccattttatatctcctttctttttt	CRISPR spacer
ctctttttagccattttttacctcctttctttagt	Protospacer
.   *  ********** **.***********  *

220. spacer 35.1|3606973|44|NZ_AP022557|CRISPRCasFinder matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 10, identity: 0.773

gtcggcaagcgt-tgattttcatccccgggtggagggcaaaacgt	CRISPR spacer
-aggactgacgcatgattttcatccctgggtggagggcaaagcgt	Protospacer
   *.* ..**. *************.**************.***

221. spacer 28.10|3355295|34|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to MN694028 (Marine virus AFVG_250M137, complete genome) position: , mismatch: 11, identity: 0.676

ataaccaaacatcaccttttcctaatttaagacc	CRISPR spacer
cctcctgtacatcaccttttctcaatttaagaga	Protospacer
 .  *.. *************..*********

222. spacer 28.21|3356018|35|NZ_AP022557|CRISPRCasFinder,CRT,PILER-CR matches to MN694494 (Marine virus AFVG_250M305, complete genome) position: , mismatch: 11, identity: 0.686

taaataatagccattttatatctcctttctttttt	CRISPR spacer
attcctttagccattttatttctcctttatttatg	Protospacer
    .  ************ ******** *** *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

233746 : 293827

Bacillus_virus(20.0%)

coat,tRNA,protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033844247.1\|233746_235012_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	8.3e-151	67.0
WP_033844246.1\|235152_236826_+\|protease	ATP-dependent protease LonB	A0A076FMQ5	Aureococcus_anophage	1.1e-12	32.7
WP_061912463.1\|237105_239433_+	endopeptidase La	A0A0R6PGP8	Moraxella_phage	3.5e-171	43.3
WP_033844245.1\|239429_240017_+	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_061912446.1\|240031_240517_-	hypothetical protein	NA	NA	NA	NA
WP_061912447.1\|240743_242111_+\|tRNA	glutamyl-tRNA reductase	NA	NA	NA	NA
WP_061912448.1\|242073_242940_+	cytochrome c biogenesis protein CcsA	NA	NA	NA	NA
WP_061912449.1\|242955_243885_+	hydroxymethylbilane synthase	NA	NA	NA	NA
WP_172418793.1\|244649_245624_+	porphobilinogen synthase	NA	NA	NA	NA
WP_061912450.1\|245639_246929_+	glutamate-1-semialdehyde 2,1-aminomutase	NA	NA	NA	NA
WP_061912451.1\|247124_248126_+	stage VI sporulation protein D	NA	NA	NA	NA
WP_061912452.1\|248169_249201_+\|coat	spore coat protein YsxE	NA	NA	NA	NA
WP_033844238.1\|249457_249646_-	hypothetical protein	NA	NA	NA	NA
WP_061912453.1\|250339_252982_+\|tRNA	valine--tRNA ligase	A0A1V0S951	Catovirus	1.1e-165	42.5
WP_061912454.1\|253115_254408_+	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_172418449.1\|254487_257346_+	VWA domain-containing protein	NA	NA	NA	NA
WP_061912455.1\|257525_259208_-	hypothetical protein	NA	NA	NA	NA
WP_061912456.1\|259219_259786_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_082799310.1\|259769_260645_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_172418450.1\|260601_262362_+	hypothetical protein	NA	NA	NA	NA
WP_061912467.1\|262367_263144_+	PRC-barrel domain-containing protein	NA	NA	NA	NA
WP_081897306.1\|263323_264496_+	G5 domain-containing protein	NA	NA	NA	NA
WP_033844230.1\|264492_266157_+	Flp pilus assembly complex ATPase component TadA	NA	NA	NA	NA
WP_033844229.1\|266169_267225_+	type IV pilus twitching motility protein PilT	NA	NA	NA	NA
WP_033844228.1\|267211_268423_+	type II secretion system F family protein	NA	NA	NA	NA
WP_033844227.1\|268516_268978_+	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_033844226.1\|268996_269752_+	prepilin peptidase	NA	NA	NA	NA
WP_033844225.1\|269781_270717_+	pilus assembly protein PilM	NA	NA	NA	NA
WP_033844224.1\|270706_271276_+	fimbrial protein	NA	NA	NA	NA
WP_061912357.1\|271272_271983_+	hypothetical protein	NA	NA	NA	NA
WP_061912356.1\|272013_272475_+	type II secretion system protein	NA	NA	NA	NA
WP_061912355.1\|272591_273662_+	hypothetical protein	NA	NA	NA	NA
WP_061912354.1\|273978_274560_+	septum formation inhibitor Maf	NA	NA	NA	NA
WP_172418794.1\|274823_275495_+	DNA repair protein RadC	NA	NA	NA	NA
WP_033020258.1\|275669_276692_+	rod shape-determining protein	NA	NA	NA	NA
WP_061912353.1\|276712_277579_+	rod shape-determining protein MreC	NA	NA	NA	NA
WP_061912352.1\|277575_278094_+	rod shape-determining protein MreD	NA	NA	NA	NA
WP_172418451.1\|278144_278831_+	septum site-determining protein MinC	NA	NA	NA	NA
WP_033020252.1\|278833_279637_+	septum site-determining protein MinD	NA	NA	NA	NA
WP_172418452.1\|279799_280567_+	M23 family metallopeptidase	NA	NA	NA	NA
WP_033020250.1\|280559_281423_+\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_033020249.1\|281654_281963_+	50S ribosomal protein L21	NA	NA	NA	NA
WP_172418453.1\|281964_282297_+\|protease	ribosomal-processing cysteine protease Prp	NA	NA	NA	NA
WP_008881065.1\|282312_282603_+	50S ribosomal protein L27	NA	NA	NA	NA
WP_033020246.1\|282904_283450_+	Spo0B domain-containing protein	NA	NA	NA	NA
WP_172418454.1\|283592_284894_+	GTPase ObgE	NA	NA	NA	NA
WP_033020242.1\|284911_285355_+	ACT domain-containing protein	NA	NA	NA	NA
WP_172418795.1\|285378_286230_+	prephenate dehydratase	NA	NA	NA	NA
WP_172418455.1\|286280_286820_-	transcription repressor NadR	NA	NA	NA	NA
WP_172418456.1\|286816_287962_-	IscS subfamily cysteine desulfurase	A0A1X6WFP1	Pacmanvirus	1.7e-30	27.3
WP_172418457.1\|288062_289616_+	L-aspartate oxidase	NA	NA	NA	NA
WP_172418458.1\|289647_290478_+	carboxylating nicotinate-nucleotide diphosphorylase	NA	NA	NA	NA
WP_172418459.1\|290492_291596_+	quinolinate synthase NadA	NA	NA	NA	NA
WP_172418460.1\|292228_293827_+\|coat	SafA/ExsA family spore coat assembly protein	NA	NA	NA	NA

DBSCAN-SWA_2

587076 : 597023

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_081897231.1\|587076_588177_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	5.7e-55	38.9
WP_033844108.1\|588176_588824_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.5e-39	44.0
WP_033844107.1\|588851_590045_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.4e-115	53.3
WP_033844106.1\|590063_590528_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.7e-43	62.2
WP_033844105.1\|590639_590996_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_033844104.1\|591036_591549_-	DUF309 domain-containing protein	NA	NA	NA	NA
WP_033023498.1\|591758_592514_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	1.0e-07	23.7
WP_033844103.1\|592659_593286_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	9.5e-15	35.4
WP_033844102.1\|593335_593728_+	hypothetical protein	NA	NA	NA	NA
WP_156102731.1\|593946_594297_-	DUF2935 domain-containing protein	NA	NA	NA	NA
WP_033844100.1\|594334_595591_+	superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	1.3e-39	44.6
WP_033844951.1\|595907_597023_+	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	1.1e-21	33.6

DBSCAN-SWA_3

2015357 : 2107049

Bacillus_virus(20.83%)

portal,holin,tail,capsid,bacteriocin,terminase,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033843238.1\|2015357_2015570_-\|bacteriocin	circular bacteriocin, circularin A/uberolysin family	NA	NA	NA	NA
WP_172418625.1\|2015607_2015784_-	hypothetical protein	NA	NA	NA	NA
WP_033843237.1\|2016808_2018659_+	bifunctional homocysteine S-methyltransferase/methylenetetrahydrofolate reductase	NA	NA	NA	NA
WP_033843236.1\|2018651_2022062_+	methionine synthase	A0A140XBC7	Dickeya_phage	1.3e-09	46.7
WP_081897285.1\|2022479_2022824_-	DUF1878 family protein	NA	NA	NA	NA
WP_033843235.1\|2023120_2023306_+	hypothetical protein	NA	NA	NA	NA
WP_033843234.1\|2023782_2024646_+	glucose 1-dehydrogenase	A0A2N9QUX2	Trichoplusia_ni_ascovirus	7.8e-60	45.9
WP_033843233.1\|2025364_2025703_-	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_033843232.1\|2025728_2026100_-	hypothetical protein	NA	NA	NA	NA
WP_033019716.1\|2026453_2026732_-	hypothetical protein	NA	NA	NA	NA
WP_051962628.1\|2026978_2027674_+	hypothetical protein	NA	NA	NA	NA
WP_033019711.1\|2027959_2028979_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_033019709.1\|2029003_2030539_-	alpha-amylase	NA	NA	NA	NA
WP_033019707.1\|2030685_2031528_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_033843231.1\|2031527_2032808_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_172418626.1\|2032877_2034149_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_172418627.1\|2034392_2036156_+	alpha-glycosidase	NA	NA	NA	NA
WP_172418819.1\|2036325_2038173_-	asparagine synthase (glutamine-hydrolyzing)	A0A1B1ISV2	uncultured_Mediterranean_phage	1.5e-23	26.4
WP_172418628.1\|2038422_2038971_+	DUF2777 domain-containing protein	NA	NA	NA	NA
WP_172418820.1\|2039071_2041912_-	EAL domain-containing protein	A0A2D0W9B6	Bordetella_phage	1.9e-06	37.6
WP_172418629.1\|2042056_2042209_-	hypothetical protein	NA	NA	NA	NA
WP_033844802.1\|2042721_2043075_-	YisL family protein	NA	NA	NA	NA
WP_033843227.1\|2043269_2044172_-	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_172418821.1\|2044610_2044793_+	aspartyl-phosphate phosphatase Spo0E family protein	NA	NA	NA	NA
WP_172418630.1\|2044805_2046065_-	DUF418 domain-containing protein	NA	NA	NA	NA
WP_033019685.1\|2046723_2046948_-	spore germination protein	NA	NA	NA	NA
WP_033019684.1\|2047094_2047319_+	spore germination protein	NA	NA	NA	NA
WP_033011654.1\|2047385_2047607_+	spore germination protein	NA	NA	NA	NA
WP_033019681.1\|2047620_2047845_+	spore gernimation protein	NA	NA	NA	NA
WP_033843225.1\|2047926_2048529_+	spore gernimation protein GerPC	NA	NA	NA	NA
WP_033019677.1\|2048525_2048717_+	hypothetical protein	NA	NA	NA	NA
WP_033843224.1\|2048713_2049091_+	spore germination protein GerPE	NA	NA	NA	NA
WP_033843223.1\|2049200_2049422_+	spore germination protein	NA	NA	NA	NA
WP_033843221.1\|2049509_2052851_-	chromosome segregation protein SMC	I3WVG4	Acinetobacter_phage	2.3e-06	27.3
WP_033843220.1\|2052847_2054032_-	exonuclease SbcCD subunit D	NA	NA	NA	NA
WP_033843219.1\|2054124_2057853_-	helicase-exonuclease AddAB subunit AddA	G3MA40	Bacillus_virus	2.7e-16	27.7
WP_033843218.1\|2057849_2061371_-	helicase-exonuclease AddAB subunit AddB	NA	NA	NA	NA
WP_033843217.1\|2061555_2062104_-	signal peptidase I	NA	NA	NA	NA
WP_033843216.1\|2062100_2062724_-	TVP38/TMEM64 family protein	NA	NA	NA	NA
WP_172418631.1\|2063186_2063369_-	hypothetical protein	A6XML5	Bacillus_virus	2.0e-18	81.7
WP_172418632.1\|2063383_2063782_-	hypothetical protein	A6XML4	Bacillus_virus	2.3e-59	94.7
WP_172418633.1\|2063794_2064385_-	replication-relaxation family protein	B3RH37	Bacillus_virus	2.9e-98	90.3
WP_172418634.1\|2064320_2065652_-	cell division protein FtsK	B3RH36	Bacillus_virus	4.5e-208	81.5
WP_061567374.1\|2065974_2066199_+	helix-turn-helix transcriptional regulator	B3RH35	Bacillus_virus	3.2e-34	91.9
WP_172418635.1\|2066526_2067372_+	MBL fold metallo-hydrolase	Q0H255	Geobacillus_phage	6.6e-136	87.5
WP_172418636.1\|2067372_2067588_+	DUF3006 domain-containing protein	Q0H256	Geobacillus_phage	1.4e-26	88.7
WP_172418822.1\|2067619_2067865_-	DNA-binding protein	A0A290FZJ4	Caldibacillus_phage	6.3e-15	52.5
WP_172418637.1\|2069004_2069430_-\|holin	phage holin family protein	Q0H258	Geobacillus_phage	3.4e-40	63.2
WP_172418638.1\|2069444_2070899_-	hypothetical protein	Q0H227	Geobacillus_phage	1.2e-33	29.5
WP_172418639.1\|2070912_2072559_-\|tail	phage tail protein	B2VQ46	Geobacillus_phage	1.1e-123	47.0
WP_172418640.1\|2072596_2073511_-	hypothetical protein	NA	NA	NA	NA
WP_172418641.1\|2073524_2074307_-\|tail	phage tail family protein	NA	NA	NA	NA
WP_172418642.1\|2074303_2076595_-	hypothetical protein	A0A2I7QIQ2	Bacillus_phage	5.3e-63	39.2
WP_172418643.1\|2076595_2077225_-	hypothetical protein	A0A1B1P868	Bacillus_phage	4.0e-21	35.4
WP_172418644.1\|2077226_2077613_-	hypothetical protein	A0A1B1P876	Bacillus_phage	1.1e-16	38.3
WP_172418645.1\|2077688_2078126_-\|capsid	capsid protein	O03972	Lactobacillus_phage	2.3e-20	38.2
WP_172418646.1\|2078129_2078519_-\|capsid	minor capsid protein	B5LPR9	Bacillus_virus	4.1e-08	38.1
WP_172418647.1\|2078531_2078891_-\|capsid	minor capsid protein	B5LPR8	Bacillus_virus	1.1e-31	67.0
WP_172418648.1\|2078887_2079229_-\|capsid	minor capsid protein	NA	NA	NA	NA
WP_172418649.1\|2079221_2079596_-	hypothetical protein	A0A2I7QIP5	Bacillus_phage	7.4e-15	40.8
WP_172418650.1\|2079598_2079766_-	hypothetical protein	NA	NA	NA	NA
WP_172418651.1\|2079778_2080774_-\|capsid	phage capsid protein	A0A1V0E621	Streptomyces_phage	8.7e-71	46.2
WP_172418652.1\|2081572_2082673_-\|capsid	minor capsid protein	A0A1B1P858	Bacillus_phage	1.5e-103	53.5
WP_172418653.1\|2082669_2084148_-\|portal	phage portal protein	A0A1B1P863	Bacillus_phage	2.1e-169	64.2
WP_172418654.1\|2084160_2085432_-\|terminase	PBSX family phage terminase large subunit	D2XPX9	Bacillus_virus	7.7e-189	73.0
WP_172418655.1\|2085424_2086177_-	helix-turn-helix domain-containing protein	A0A2P1JTW4	Anoxybacillus_phage	3.2e-65	65.5
WP_172418656.1\|2087083_2087827_-	hypothetical protein	D2XR29	Bacillus_phage	8.6e-39	39.6
WP_172418823.1\|2088011_2088449_-	ArpU family transcriptional regulator	Q0H270	Geobacillus_phage	6.3e-66	86.2
WP_172418657.1\|2088554_2088695_-	hypothetical protein	NA	NA	NA	NA
WP_172418658.1\|2088938_2089076_-	hypothetical protein	NA	NA	NA	NA
WP_172418659.1\|2089095_2089320_-	hypothetical protein	NA	NA	NA	NA
WP_172418660.1\|2089346_2089934_-	hypothetical protein	S6C473	Thermus_phage	1.5e-25	38.3
WP_172418661.1\|2089939_2090293_-	hypothetical protein	NA	NA	NA	NA
WP_172418662.1\|2090289_2090589_-	hypothetical protein	A6M999	Geobacillus_virus	4.3e-42	92.6
WP_033021461.1\|2090731_2090929_-	hypothetical protein	W8EEZ5	Geobacillus_phage	6.6e-31	93.8
WP_172418663.1\|2091004_2091172_-	hypothetical protein	S6B9Z0	Thermus_phage	4.6e-09	53.7
WP_031405301.1\|2091155_2091377_-	hypothetical protein	S6C474	Thermus_phage	3.3e-31	83.6
WP_172418824.1\|2091380_2092199_-	ATP-binding protein	S6B1M2	Thermus_phage	2.8e-123	80.7
WP_172418664.1\|2093025_2093184_-	hypothetical protein	E5DV81	Deep-sea_thermophilic_phage	7.9e-11	55.8
WP_172418665.1\|2093183_2094014_-	hypothetical protein	A6M982	Geobacillus_virus	1.3e-104	83.1
WP_172418666.1\|2094015_2094567_-	host-nuclease inhibitor Gam family protein	Q9ZXC8	Bacillus_phage	3.7e-31	44.0
WP_172418825.1\|2094563_2094776_-	hypothetical protein	NA	NA	NA	NA
WP_172418667.1\|2094870_2095071_-	hypothetical protein	S6B1M6	Thermus_phage	2.4e-28	81.5
WP_165570952.1\|2095242_2095404_-	hypothetical protein	NA	NA	NA	NA
WP_031405318.1\|2095403_2095667_-	hypothetical protein	A6XMM3	Bacillus_virus	2.3e-23	67.8
WP_172418826.1\|2095663_2096359_-	antA/AntB antirepressor family protein	A0A0B5D0I2	Listeria_phage	1.4e-30	55.1
WP_172418668.1\|2096407_2096716_-	hypothetical protein	NA	NA	NA	NA
WP_172418669.1\|2096765_2097041_-	hypothetical protein	NA	NA	NA	NA
WP_172418670.1\|2097071_2097248_-	hypothetical protein	A6M976	Geobacillus_virus	9.4e-21	86.0
WP_172418827.1\|2097373_2098003_-	phage repressor protein	A0A1W6JPC3	Staphylococcus_phage	1.6e-41	45.1
WP_172418671.1\|2098035_2098239_-	helix-turn-helix transcriptional regulator	E5DV75	Deep-sea_thermophilic_phage	2.6e-30	98.5
WP_172418672.1\|2098396_2099017_+	helix-turn-helix domain-containing protein	E5DV74	Deep-sea_thermophilic_phage	1.9e-108	96.6
WP_172418673.1\|2099083_2100523_+	recombinase family protein	A0A1L2JY12	Aeribacillus_phage	6.6e-112	46.9
WP_033019657.1\|2101149_2101344_-	hypothetical protein	NA	NA	NA	NA
WP_033843214.1\|2101530_2102817_-	isocitrate lyase	NA	NA	NA	NA
WP_033843213.1\|2103007_2103601_+	SCO family protein	NA	NA	NA	NA
WP_033843212.1\|2103669_2103975_-	AzlD domain-containing protein	NA	NA	NA	NA
WP_172418674.1\|2103967_2104684_-	AzlC family ABC transporter permease	NA	NA	NA	NA
WP_081130697.1\|2105675_2107049_-\|transposase	IS1380 family transposase	NA	NA	NA	NA

DBSCAN-SWA_4

2535361 : 2603796

Wolbachia_phage(27.27%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033842531.1\|2535361_2536498_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.0e-35	28.0
WP_033842531.1\|2536917_2538054_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.0e-35	28.0
WP_033842531.1\|2538692_2539829_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.0e-35	28.0
WP_172418709.1\|2540868_2543580_-	S-layer protein	NA	NA	NA	NA
WP_061912229.1\|2543956_2544736_-	hypothetical protein	NA	NA	NA	NA
WP_172418710.1\|2544770_2546114_-	peptidoglycan-binding protein	A0A0A8WF62	Clostridium_phage	1.6e-14	41.7
WP_061912231.1\|2546293_2546779_-	hypothetical protein	NA	NA	NA	NA
WP_172418711.1\|2546987_2547395_+	helix-turn-helix domain-containing protein	A0A1S5SG49	Streptococcus_phage	5.2e-06	43.3
WP_172418712.1\|2547781_2548141_-	single-stranded DNA-binding protein	A0A059T5E0	Listeria_phage	6.8e-34	68.0
WP_172418713.1\|2548392_2548845_+	hypothetical protein	NA	NA	NA	NA
WP_051962599.1\|2549148_2549808_-	class D sortase	NA	NA	NA	NA
WP_153017119.1\|2549814_2550729_-	processed acidic surface protein	NA	NA	NA	NA
WP_033842985.1\|2551326_2552703_-	aspartate kinase	NA	NA	NA	NA
WP_033842984.1\|2553303_2553738_-	DUF1284 domain-containing protein	NA	NA	NA	NA
WP_033842983.1\|2554047_2554608_+	hypothetical protein	NA	NA	NA	NA
WP_033842982.1\|2555364_2556885_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_033842980.1\|2557133_2557508_+	hypothetical protein	NA	NA	NA	NA
WP_156102687.1\|2557511_2558189_+	hypothetical protein	NA	NA	NA	NA
WP_033842977.1\|2558398_2558758_+	DUF779 domain-containing protein	NA	NA	NA	NA
WP_033842975.1\|2558951_2560559_-	MFS transporter	NA	NA	NA	NA
WP_033842974.1\|2560543_2561467_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_033018377.1\|2561459_2561600_-	hypothetical protein	NA	NA	NA	NA
WP_172418833.1\|2561772_2562660_-	ROK family protein	NA	NA	NA	NA
WP_033842973.1\|2563300_2563855_+	NADPH-dependent FMN reductase	NA	NA	NA	NA
WP_033842972.1\|2563966_2564875_+	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	4.0e-14	26.0
WP_033842971.1\|2564977_2565337_+	hypothetical protein	NA	NA	NA	NA
WP_033842970.1\|2565432_2566551_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_033842969.1\|2566665_2567979_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_051962597.1\|2568034_2569288_+	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_033842968.1\|2569301_2570315_+	methionine ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.9e-29	38.4
WP_014196859.1\|2570304_2570961_+	ABC transporter permease	NA	NA	NA	NA
WP_033018366.1\|2571077_2571908_+	methionine ABC transporter ATPase	NA	NA	NA	NA
WP_033842967.1\|2571969_2573361_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_081897157.1\|2573482_2574268_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_033842966.1\|2574893_2575715_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_033842965.1\|2575714_2576686_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_033842964.1\|2576747_2578043_-	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_033842963.1\|2578354_2579896_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_033842961.1\|2579873_2581343_-	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	2.3e-19	28.6
WP_033842959.1\|2581574_2582588_-	sugar-binding protein	NA	NA	NA	NA
WP_033842958.1\|2582730_2583621_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_033842957.1\|2583834_2585178_-	6-phospho-beta-glucosidase	NA	NA	NA	NA
WP_033842956.1\|2585302_2586070_+	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_081130697.1\|2589251_2590625_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_033842954.1\|2590825_2592193_-	FAD-binding protein	NA	NA	NA	NA
WP_033842953.1\|2592271_2593249_-	alpha-ketoacid dehydrogenase subunit beta	NA	NA	NA	NA
WP_033842952.1\|2593249_2594329_-	pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha	NA	NA	NA	NA
WP_033842951.1\|2594404_2595697_-	2-oxo acid dehydrogenase subunit E2	NA	NA	NA	NA
WP_033842950.1\|2596236_2596437_-	hypothetical protein	NA	NA	NA	NA
WP_033842949.1\|2596705_2597692_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_033842948.1\|2597850_2598288_-	DUF4275 family protein	NA	NA	NA	NA
WP_081897156.1\|2598266_2598446_-	hypothetical protein	NA	NA	NA	NA
WP_033844743.1\|2598507_2598927_-	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	1.4e-41	59.0
WP_033842947.1\|2598969_2599329_-	winged helix-turn-helix transcriptional regulator	A0A218MNF3	uncultured_virus	2.4e-10	44.4
WP_033842946.1\|2599523_2599907_-	DUF1360 domain-containing protein	NA	NA	NA	NA
WP_033842940.1\|2602128_2603796_+\|transposase	IS1634 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

2749158 : 2829782

Bacillus_phage(33.33%)

coat,tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033842853.1\|2749158_2750832_-\|tRNA	arginine--tRNA ligase	NA	NA	NA	NA
WP_033842852.1\|2750836_2751268_-	DUF1934 domain-containing protein	NA	NA	NA	NA
WP_031406593.1\|2751425_2752301_-	agmatinase	NA	NA	NA	NA
WP_033021876.1\|2752314_2753142_-	polyamine aminopropyltransferase	NA	NA	NA	NA
WP_033842850.1\|2753360_2755406_+	PBP1A family penicillin-binding protein	NA	NA	NA	NA
WP_033844735.1\|2755587_2756106_+	type II toxin-antitoxin system PemK/MazF family toxin	NA	NA	NA	NA
WP_061912528.1\|2756837_2758121_+\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	3.9e-15	21.2
WP_033842847.1\|2758700_2759318_-	amino acid transporter	NA	NA	NA	NA
WP_033017768.1\|2760216_2760726_+	DUF4829 domain-containing protein	NA	NA	NA	NA
WP_156102683.1\|2761418_2761562_+	hypothetical protein	NA	NA	NA	NA
WP_172418719.1\|2761671_2763333_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_081130697.1\|2764672_2766046_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_033842841.1\|2766547_2767786_-	Tm-1-like ATP-binding domain-containing protein	NA	NA	NA	NA
WP_026500105.1\|2767876_2769070_-	phosphoenolpyruvate hydrolase family protein	NA	NA	NA	NA
WP_033842839.1\|2769300_2770434_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_033842837.1\|2770616_2771807_+\|transposase	ISL3 family transposase	A0A0A8WEF4	Clostridium_phage	8.9e-30	25.4
WP_003251249.1\|2772037_2772286_-	MafI family immunity protein	NA	NA	NA	NA
WP_172418720.1\|2774089_2774797_+	hypothetical protein	NA	NA	NA	NA
WP_172418836.1\|2775050_2775788_+	arginase family protein	NA	NA	NA	NA
WP_172418837.1\|2775774_2776053_+	MFS transporter	NA	NA	NA	NA
WP_081130697.1\|2776248_2777622_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_172418721.1\|2777816_2778716_+	MFS transporter	NA	NA	NA	NA
WP_172418722.1\|2778957_2780625_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_033842835.1\|2783453_2783870_-	hypothetical protein	A0A2H4J4V0	uncultured_Caudovirales_phage	9.0e-38	53.7
WP_081897278.1\|2783981_2785085_-	hypothetical protein	NA	NA	NA	NA
WP_061912366.1\|2786147_2786663_-	YwhD family protein	NA	NA	NA	NA
WP_033023324.1\|2786681_2787350_-\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_020961553.1\|2787481_2787670_+	4-oxalocrotonate tautomerase	NA	NA	NA	NA
WP_061912367.1\|2787771_2789073_+	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	2.0e-46	33.0
WP_061912368.1\|2789117_2789636_-	hypothetical protein	NA	NA	NA	NA
WP_061912369.1\|2789649_2790948_-	HD domain-containing protein	E3T4P8	Cafeteria_roenbergensis_virus	1.0e-23	27.8
WP_033021653.1\|2791239_2791467_-	DUF1450 domain-containing protein	NA	NA	NA	NA
WP_033021651.1\|2791641_2792295_+	RsfA family transcriptional regulator	A0A1D6X8E5	Bacillus_phage	8.4e-06	48.5
WP_061912370.1\|2792501_2793371_-	lipoate--protein ligase family protein	NA	NA	NA	NA
WP_061912371.1\|2793771_2794752_-	phosphate acetyltransferase	NA	NA	NA	NA
WP_033842832.1\|2795164_2795911_+	heme-dependent peroxidase	NA	NA	NA	NA
WP_033842830.1\|2797862_2798291_+	cell wall hydrolase	NA	NA	NA	NA
WP_033021622.1\|2798318_2798867_+\|coat	spore coat protein GerQ	NA	NA	NA	NA
WP_033842829.1\|2799250_2799622_-	DUF423 domain-containing protein	NA	NA	NA	NA
WP_033021616.1\|2799903_2800203_-	YwdI family protein	NA	NA	NA	NA
WP_033842828.1\|2800219_2800909_-	uracil-DNA glycosylase	A0A0B5IW78	Pandoravirus	7.1e-56	50.6
WP_033842827.1\|2801045_2801429_-	DUF1232 domain-containing protein	NA	NA	NA	NA
WP_033842826.1\|2801553_2801904_+	STAS domain-containing protein	NA	NA	NA	NA
WP_033842825.1\|2801900_2802389_+	anti-sigma B factor RsbW	NA	NA	NA	NA
WP_033021603.1\|2802348_2803119_+	sigma-70 family RNA polymerase sigma factor	A0A0Y0AU18	Bacillus_phage	1.1e-17	31.6
WP_033842822.1\|2803258_2805169_-	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_033842821.1\|2805316_2805952_-	FMN-dependent NADH-azoreductase	NA	NA	NA	NA
WP_172418433.1\|2806133_2806280_-	hypothetical protein	NA	NA	NA	NA
WP_081130697.1\|2806534_2807908_+\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_172418723.1\|2808179_2808281_-	hypothetical protein	NA	NA	NA	NA
WP_033842820.1\|2808398_2808632_+	hypothetical protein	NA	NA	NA	NA
WP_033842819.1\|2809784_2810198_-	hypothetical protein	NA	NA	NA	NA
WP_033842818.1\|2810279_2810468_-	hypothetical protein	NA	NA	NA	NA
WP_033842817.1\|2810553_2811045_-	hypothetical protein	NA	NA	NA	NA
WP_033842816.1\|2811192_2812101_-	hypothetical protein	NA	NA	NA	NA
WP_033842814.1\|2812119_2813013_-	type II secretion system F family protein	NA	NA	NA	NA
WP_033842813.1\|2813026_2813947_-	type II secretion system F family protein	NA	NA	NA	NA
WP_033842812.1\|2813943_2815335_-	CpaF family protein	NA	NA	NA	NA
WP_172418724.1\|2815331_2816690_-	AAA family ATPase	NA	NA	NA	NA
WP_033842809.1\|2816678_2817812_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_033842808.1\|2817869_2818592_-	Flp pilus assembly protein CpaB	NA	NA	NA	NA
WP_033842806.1\|2821448_2821799_+	DUF3221 domain-containing protein	NA	NA	NA	NA
WP_033842805.1\|2821878_2822652_+\|protease	trypsin-like serine protease	NA	NA	NA	NA
WP_033842803.1\|2823413_2824796_-\|tRNA	glycine--tRNA ligase	A0A1V0SAN4	Catovirus	3.3e-52	30.1
WP_033842802.1\|2825087_2825918_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_172418725.1\|2826137_2827334_-	MFS transporter	NA	NA	NA	NA
WP_033842799.1\|2827840_2828158_+	hypothetical protein	NA	NA	NA	NA
WP_081130697.1\|2828408_2829782_-\|transposase	IS1380 family transposase	NA	NA	NA	NA

DBSCAN-SWA_6

3117268 : 3150889

Wolbachia_phage(33.33%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418741.1\|3117268_3117907_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_033842624.1\|3118013_3118403_+	holo-ACP synthase	NA	NA	NA	NA
WP_033842623.1\|3118482_3119496_+	outer membrane lipoprotein carrier protein LolA	NA	NA	NA	NA
WP_033842622.1\|3120226_3121393_+	alanine racemase	NA	NA	NA	NA
WP_033023681.1\|3121507_3121789_+	hypothetical protein	NA	NA	NA	NA
WP_003253417.1\|3121793_3122144_+	type II toxin-antitoxin system endoribonuclease NdoA	A0A2P0ZKX3	Lactobacillus_phage	2.0e-14	38.6
WP_033842620.1\|3122453_3124619_+	RNA-binding transcriptional accessory protein	NA	NA	NA	NA
WP_089135018.1\|3124635_3124749_-	cortex morphogenetic protein CmpA	NA	NA	NA	NA
WP_033842619.1\|3124840_3125305_+	SprT family protein	U5J9G1	Bacillus_phage	7.0e-07	27.8
WP_033020404.1\|3133020_3133479_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	NA	NA	NA	NA
WP_033842618.1\|3133475_3134216_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_033842616.1\|3134175_3134631_+	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_033842614.1\|3134623_3135640_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	3.9e-66	43.2
WP_033842612.1\|3135967_3137893_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L0W2	Tupanvirus	6.2e-57	31.0
WP_033844717.1\|3137991_3138480_+	cyclic pyranopterin monophosphate synthase MoaC	NA	NA	NA	NA
WP_033842611.1\|3138495_3139158_+	redox-sensing transcriptional repressor Rex	NA	NA	NA	NA
WP_033842610.1\|3139154_3139307_+	twin-arginine translocase TatA/TatE family subunit	NA	NA	NA	NA
WP_033842609.1\|3139326_3140070_+	twin-arginine translocase subunit TatC	NA	NA	NA	NA
WP_081897147.1\|3140421_3140580_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_033842606.1\|3141886_3143170_-\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	1.3e-15	22.5
WP_033842604.1\|3143965_3144844_-	ABC transporter ATP-binding protein	F2Y2R6	Organic_Lake_phycodnavirus	9.2e-16	30.0
WP_033842531.1\|3145691_3146828_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.0e-35	28.0
WP_172418742.1\|3147527_3147716_+	hypothetical protein	NA	NA	NA	NA
WP_033842531.1\|3147834_3148971_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.0e-35	28.0
WP_172418742.1\|3149445_3149634_+	hypothetical protein	NA	NA	NA	NA
WP_033842531.1\|3149752_3150889_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.0e-35	28.0

DBSCAN-SWA_7

3178152 : 3186561

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033842583.1\|3178152_3179448_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	5.0e-18	34.3
WP_033842582.1\|3179523_3180252_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3FUQ7	Synechococcus_phage	4.1e-46	42.4
WP_033018440.1\|3180239_3180494_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_033018439.1\|3180490_3181177_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_033842581.1\|3181160_3183389_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.5e-166	41.6
WP_033842580.1\|3183364_3184777_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.2e-51	35.6
WP_033842579.1\|3184894_3185935_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	1.1e-65	45.8
WP_033842578.1\|3185931_3186561_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	1.0e-24	34.6

DBSCAN-SWA_8

3230289 : 3378450

Bacillus_phage(31.25%)

integrase,transposase,protease,holin

attL 3314562:3314580|attR 3326874:3326892

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033842551.1\|3230289_3231417_-\|holin	betaine/proline/choline family ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	5.5e-29	35.5
WP_033842550.1\|3232776_3233340_-	coiled-coil protein	NA	NA	NA	NA
WP_033842548.1\|3233487_3234999_+	TIGR02677 family protein	NA	NA	NA	NA
WP_033842546.1\|3234982_3236140_+	TIGR02678 family protein	NA	NA	NA	NA
WP_033844709.1\|3236139_3240258_+	TIGR02680 family protein	NA	NA	NA	NA
WP_033842544.1\|3240254_3241475_+	TIGR02679 family protein	NA	NA	NA	NA
WP_033842542.1\|3243933_3245136_+	putative CRISPR-associated protein	NA	NA	NA	NA
WP_033842539.1\|3245138_3246464_+	TIGR02221 family CRISPR-associated protein	NA	NA	NA	NA
WP_108209764.1\|3246474_3247383_+	type III-B CRISPR module RAMP protein Cmr1	NA	NA	NA	NA
WP_033022457.1\|3247379_3249023_+	type III-B CRISPR-associated protein Cas10/Cmr2	NA	NA	NA	NA
WP_033022459.1\|3249019_3250150_+	CRISPR-associated protein Cmr3	NA	NA	NA	NA
WP_033022461.1\|3250149_3251043_+	type III-B CRISPR module RAMP protein Cmr4	NA	NA	NA	NA
WP_033022462.1\|3251058_3251469_+	type III-B CRISPR module-associated protein Cmr5	NA	NA	NA	NA
WP_033022463.1\|3251481_3252627_+	type III-B CRISPR module RAMP protein Cmr6	NA	NA	NA	NA
WP_033022465.1\|3256651_3258367_+	TIGR02556 family CRISPR-associated protein	NA	NA	NA	NA
WP_033022466.1\|3258368_3259325_+	type I-B CRISPR-associated protein Cas7/Csh2	NA	NA	NA	NA
WP_033022467.1\|3259340_3260084_+	type I-B CRISPR-associated protein Cas5	NA	NA	NA	NA
WP_033022473.1\|3260085_3262419_+	CRISPR-associated helicase/endonuclease Cas3	NA	NA	NA	NA
WP_033022476.1\|3262428_3262938_+	CRISPR-associated protein Cas4	NA	NA	NA	NA
WP_033022482.1\|3262940_3263942_+	type I-B CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_172418743.1\|3263953_3264217_+	CRISPR-associated endonuclease Cas2	NA	NA	NA	NA
WP_033842534.1\|3264387_3265134_+	CRISPR-associated endoribonuclease Cas6	NA	NA	NA	NA
WP_033842532.1\|3267278_3268187_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_033842531.1\|3269041_3270178_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.0e-35	28.0
WP_156102755.1\|3270725_3270893_+	hypothetical protein	NA	NA	NA	NA
WP_033842531.1\|3271103_3272240_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.0e-35	28.0
WP_081897275.1\|3272616_3272880_-	CRISPR-associated endonuclease Cas2	NA	NA	NA	NA
WP_172418839.1\|3272884_3273763_-	type II CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_033844707.1\|3273713_3276977_-	type II CRISPR RNA-guided endonuclease Cas9	NA	NA	NA	NA
WP_033845048.1\|3277285_3278341_+	P1 family peptidase	NA	NA	NA	NA
WP_033844706.1\|3278502_3279741_-	MFS transporter	NA	NA	NA	NA
WP_033844703.1\|3279901_3280555_-	PspA/IM30 family protein	NA	NA	NA	NA
WP_033844702.1\|3280514_3281036_-	hypothetical protein	NA	NA	NA	NA
WP_033845047.1\|3281945_3282356_+	hypothetical protein	NA	NA	NA	NA
WP_033844700.1\|3283147_3284521_-	GHKL domain-containing protein	Q8QKV7	Ectocarpus_siliculosus_virus	1.9e-12	25.7
WP_033844699.1\|3284501_3285173_-	response regulator transcription factor	W8CYM9	Bacillus_phage	8.3e-33	35.7
WP_061912550.1\|3285309_3285600_+	hypothetical protein	NA	NA	NA	NA
WP_033844698.1\|3285599_3286808_+	trypsin-like peptidase domain-containing protein	W5SAB9	Pithovirus	1.8e-14	33.7
WP_033844696.1\|3288087_3288879_+	hydrolase	NA	NA	NA	NA
WP_033844695.1\|3288943_3289987_+	hypothetical protein	NA	NA	NA	NA
WP_033844694.1\|3290663_3291857_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_033844693.1\|3292168_3292438_-\|transposase	transposase	NA	NA	NA	NA
WP_033844692.1\|3292863_3293055_+	hypothetical protein	NA	NA	NA	NA
WP_061912549.1\|3293701_3295417_-\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_081897273.1\|3296563_3297505_+	pre-toxin TG domain-containing protein	NA	NA	NA	NA
WP_033844689.1\|3297719_3298229_+	hypothetical protein	NA	NA	NA	NA
WP_172418744.1\|3301298_3301838_+	hypothetical protein	NA	NA	NA	NA
WP_033844687.1\|3301859_3303377_+	flotillin family protein	A0A2I2L4B2	Orpheovirus	3.2e-08	27.9
WP_033844686.1\|3303784_3304705_+	diacylglycerol kinase	A0A1V0SBJ0	Catovirus	2.5e-24	28.4
WP_033844684.1\|3304779_3306159_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	3.6e-123	47.8
WP_033844683.1\|3306250_3306964_-	hypothetical protein	NA	NA	NA	NA
WP_033844682.1\|3307898_3308963_-	anti-sigma factor	NA	NA	NA	NA
WP_033845041.1\|3308959_3309445_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_156102754.1\|3310919_3311090_+	hypothetical protein	NA	NA	NA	NA
WP_033844680.1\|3312816_3314484_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
3314562:3314580	attL	NA	NA	NA	NA
WP_033844678.1\|3316788_3317031_-	glutaredoxin family protein	NA	NA	NA	NA
WP_033844676.1\|3317097_3317337_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_081897272.1\|3317347_3317512_-	YvrJ family protein	NA	NA	NA	NA
WP_051962776.1\|3317498_3318131_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_156102762.1\|3318283_3319351_-	S8 family serine peptidase	A0A127AWU5	Bacillus_phage	1.9e-68	52.0
WP_033844675.1\|3319843_3320644_-	AAA family ATPase	NA	NA	NA	NA
WP_051962771.1\|3322855_3323374_-	VOC family protein	NA	NA	NA	NA
WP_033844673.1\|3323783_3325220_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_033844670.1\|3327045_3328713_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
3326874:3326892	attR	NA	NA	NA	NA
WP_033844667.1\|3329213_3330938_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	5.3e-15	23.9
WP_033019551.1\|3330934_3331645_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.0e-36	36.6
WP_033844666.1\|3331743_3332427_+	membrane protein	NA	NA	NA	NA
WP_033020020.1\|3332426_3333344_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	4.9e-28	30.9
WP_033844665.1\|3333972_3334161_+	hypothetical protein	NA	NA	NA	NA
WP_015375695.1\|3335807_3336941_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_172418840.1\|3337041_3337491_+	RNA polymerase sigma factor	NA	NA	NA	NA
WP_033844662.1\|3337492_3337972_+	hypothetical protein	NA	NA	NA	NA
WP_033021375.1\|3338015_3338333_+	hypothetical protein	NA	NA	NA	NA
WP_172418745.1\|3339011_3339542_-	NUDIX hydrolase	NA	NA	NA	NA
WP_081897270.1\|3339815_3340442_-	DUF4277 domain-containing protein	NA	NA	NA	NA
WP_081130697.1\|3340913_3342287_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_061912642.1\|3342426_3342810_+	hypothetical protein	NA	NA	NA	NA
WP_081897269.1\|3342881_3343529_+	VanZ family protein	NA	NA	NA	NA
WP_051962767.1\|3346726_3348208_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_033844659.1\|3348264_3349554_+	MFS transporter	NA	NA	NA	NA
WP_081130697.1\|3353219_3354593_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_033844657.1\|3356592_3357978_-	L-cystine transporter	NA	NA	NA	NA
WP_172418746.1\|3358650_3360126_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_033844656.1\|3360591_3361467_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_033844655.1\|3361545_3361962_-	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_033844654.1\|3362406_3363789_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	1.1e-60	33.0
WP_033844653.1\|3363969_3364731_-	sporulation protein	NA	NA	NA	NA
WP_033844652.1\|3365112_3366279_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_033844651.1\|3366569_3367613_+	NDP-sugar synthase	I7I009	Enterobacteria_phage	8.4e-16	27.7
WP_033844650.1\|3367609_3368797_+	glycosyltransferase	NA	NA	NA	NA
WP_033844647.1\|3368777_3369893_+	hypothetical protein	NA	NA	NA	NA
WP_172418747.1\|3369843_3371250_+	phosphomannomutase/phosphoglucomutase	A0A127AWJ1	Bacillus_phage	1.6e-46	28.6
WP_033844644.1\|3371477_3373121_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_033844643.1\|3373367_3373769_+	ATP-binding protein	NA	NA	NA	NA
WP_033018122.1\|3373790_3374123_+	STAS domain-containing protein	NA	NA	NA	NA
WP_033844642.1\|3374129_3375659_+	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_081130697.1\|3377076_3378450_+\|transposase	IS1380 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_AP022557.1|WP_061912229.1|2543956_2544736_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_AP022557.1|WP_061912231.1|2546293_2546779_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_AP022557.1|WP_033018377.1|2561459_2561600_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_AP022557.1|WP_033844647.1|3368777_3369893_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_AP022557.1|WP_061912229.1|2543956_2544736_-|hypothetical-protein

2543956_2544736_-

259 aa aa

2535361-2603796

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_AP022557_20	Orphan	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	2540271-2540228	2
NZ_AP022557_30	Orphan	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	2538424-2538381	0
NZ_AP022557_30	Orphan	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	2540275-2540232	1
NZ_AP022557_31	Orphan	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	2540347-2540302	0
NZ_AP022557_31	Orphan	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	2540563-2540518	0
NZ_AP022557_31	Orphan	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	2540128-2540083	2
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	2540464-2540417	0
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	2540535-2540488	0
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	2538396-2538349	2

1. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540271-2540228, mismatch: 2

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagatccatgggcagcgtgatc	Protospacer
************************* ***********.******

2. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2538424-2538381, mismatch: 0

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	Protospacer
********************************************

3. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540275-2540232, mismatch: 1

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcagcgt	Protospacer
****************************************.***

4. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540347-2540302, mismatch: 0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

5. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540563-2540518, mismatch: 0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

6. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540128-2540083, mismatch: 2

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaacgttt	Protospacer
*****************************************.* **

7. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540464-2540417, mismatch: 0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

8. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540535-2540488, mismatch: 0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

9. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2538396-2538349, mismatch: 2

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

NZ_AP022557.1|WP_061912231.1|2546293_2546779_-|hypothetical-protein

2546293_2546779_-

161 aa aa

2535361-2603796

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_AP022557_20	Orphan	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	2540271-2540228	2
NZ_AP022557_30	Orphan	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	2538424-2538381	0
NZ_AP022557_30	Orphan	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	2540275-2540232	1
NZ_AP022557_31	Orphan	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	2540347-2540302	0
NZ_AP022557_31	Orphan	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	2540563-2540518	0
NZ_AP022557_31	Orphan	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	2540128-2540083	2
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	2540464-2540417	0
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	2540535-2540488	0
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	2538396-2538349	2

1. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540271-2540228, mismatch: 2

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagatccatgggcagcgtgatc	Protospacer
************************* ***********.******

2. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2538424-2538381, mismatch: 0

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	Protospacer
********************************************

3. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540275-2540232, mismatch: 1

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcagcgt	Protospacer
****************************************.***

4. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540347-2540302, mismatch: 0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

5. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540563-2540518, mismatch: 0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

6. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540128-2540083, mismatch: 2

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaacgttt	Protospacer
*****************************************.* **

7. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540464-2540417, mismatch: 0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

8. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540535-2540488, mismatch: 0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

9. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2538396-2538349, mismatch: 2

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

NZ_AP022557.1|WP_033018377.1|2561459_2561600_-|hypothetical-protein

2561459_2561600_-

46 aa aa

2535361-2603796

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_AP022557_20	Orphan	20.1\|2521287\|44\|NZ_AP022557\|CRISPRCasFinder	2521287-2521330	44	2540271-2540228	2
NZ_AP022557_30	Orphan	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	2538424-2538381	0
NZ_AP022557_30	Orphan	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	2540275-2540232	1
NZ_AP022557_31	Orphan	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	2540347-2540302	0
NZ_AP022557_31	Orphan	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	2540563-2540518	0
NZ_AP022557_31	Orphan	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	2540128-2540083	2
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	2540464-2540417	0
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	2540535-2540488	0
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	2538396-2538349	2

1. spacer 20.1|2521287|44|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540271-2540228, mismatch: 2

tcagttcggcattttcacggaaaagttccatgggcagtgtgatc	CRISPR spacer
tcagttcggcattttcacggaaaagatccatgggcagcgtgatc	Protospacer
************************* ***********.******

2. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2538424-2538381, mismatch: 0

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	Protospacer
********************************************

3. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540275-2540232, mismatch: 1

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcagcgt	Protospacer
****************************************.***

4. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540347-2540302, mismatch: 0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

5. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540563-2540518, mismatch: 0

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	Protospacer
**********************************************

6. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540128-2540083, mismatch: 2

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaacgttt	Protospacer
*****************************************.* **

7. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540464-2540417, mismatch: 0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

8. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2540535-2540488, mismatch: 0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

9. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 2538396-2538349, mismatch: 2

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

NZ_AP022557.1|WP_033844647.1|3368777_3369893_+|hypothetical-protein

3368777_3369893_+

371 aa aa

3230289-3378450

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_AP022557_30	Orphan	30.1\|3417378\|44\|NZ_AP022557\|CRISPRCasFinder	3417378-3417421	44	3270766-3270723	0
NZ_AP022557_31	Orphan	31.1\|3421370\|46\|NZ_AP022557\|CRISPRCasFinder	3421370-3421415	46	3272610-3272565	2
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	3270519-3270472	0
NZ_AP022557_32	Orphan	32.1\|3424577\|48\|NZ_AP022557\|CRISPRCasFinder	3424577-3424624	48	3270738-3270691	2

1. spacer 30.1|3417378|44|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 3270766-3270723, mismatch: 0

tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	CRISPR spacer
tgcgtcagttcggcattttcacggaaaagatccatgggcaacgt	Protospacer
********************************************

2. spacer 31.1|3421370|46|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 3272610-3272565, mismatch: 2

tacgccagtcctgcattttcacggaaaagatccatgggcaatggtt	CRISPR spacer
tacgccagtcctgcattttcacggaaaagatccatgggcaacgttt	Protospacer
*****************************************.* **

3. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 3270519-3270472, mismatch: 0

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	Protospacer
************************************************

4. spacer 32.1|3424577|48|NZ_AP022557|CRISPRCasFinder matches to NZ_AP022557 position: 3270738-3270691, mismatch: 2

gatccatgggcaatggtttgccctccacccggggatgaaaatccgcgc	CRISPR spacer
gatccatgggcaacgttttgccctccacccggggatgaaaatccgcgc	Protospacer
*************.* ********************************

2. NZ_AP022559

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

174 : 42786

Bacillus_phage(28.0%)

portal,transposase,protease,head,terminase,capsid,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418976.1\|174_756_-	DUF4352 domain-containing protein	E5DV69	Deep-sea_thermophilic_phage	5.8e-67	76.2
WP_172419020.1\|855_1488_-	M15 family metallopeptidase	W8EEW7	Geobacillus_phage	4.8e-83	72.0
WP_172418977.1\|1493_1754_-	hypothetical protein	E5DV67	Deep-sea_thermophilic_phage	3.8e-34	94.0
WP_172418978.1\|1753_1951_-	hemolysin XhlA family protein	A6M968	Geobacillus_virus	3.3e-22	84.6
WP_172418979.1\|1966_3112_-	hypothetical protein	A0A0K2CZQ1	Paenibacillus_phage	4.9e-86	42.2
WP_172418980.1\|3319_3703_-	hypothetical protein	S6C455	Thermus_phage	6.1e-49	76.6
WP_172418981.1\|3716_5120_-	hypothetical protein	S6B1J7	Thermus_phage	2.2e-64	56.5
WP_172418982.1\|5133_5988_-\|tail	phage tail family protein	A0A2I7SBZ7	Paenibacillus_phage	2.2e-54	38.5
WP_172418983.1\|5989_11683_-\|tail	phage tail tape measure protein	Q9ZXE7	Bacillus_phage	9.3e-109	31.2
WP_172418984.1\|11696_11840_-	hypothetical protein	D6R3Z7	Bacillus_phage	2.7e-10	64.8
WP_172418985.1\|11863_12196_-	hypothetical protein	Q9ZXE8	Bacillus_phage	1.0e-23	50.5
WP_172418986.1\|12256_12835_-\|tail	phage tail protein	Q9ZXE9	Bacillus_phage	6.2e-61	59.9
WP_041467826.1\|12846_13215_-	DUF3168 domain-containing protein	Q9ZXF0	Bacillus_phage	3.6e-30	53.7
WP_011230039.1\|13230_13617_-	HK97 gp10 family phage protein	Q9ZXF1	Bacillus_phage	3.2e-37	63.6
WP_011230038.1\|13609_13951_-\|head	phage head closure protein	Q9ZXF2	Bacillus_phage	1.6e-24	47.1
WP_011230037.1\|13922_14123_-	hypothetical protein	NA	NA	NA	NA
WP_011230036.1\|14119_14395_-\|head,tail	phage gp6-like head-tail connector protein	A0A2I7SD07	Paenibacillus_phage	1.8e-18	55.3
WP_011230035.1\|14413_15547_-\|capsid	phage major capsid protein	A0A0K2CZ99	Paenibacillus_phage	6.9e-165	77.7
WP_172419021.1\|15543_16272_-\|protease	Clp protease ClpP	A0A2I7SCY8	Paenibacillus_phage	1.5e-104	80.0
WP_172418987.1\|16288_17503_-\|portal	phage portal protein	A0A0U3SQF0	Bacillus_phage	1.5e-146	63.2
WP_172418988.1\|17524_19240_-\|terminase	terminase large subunit	A0A2I7SCY3	Paenibacillus_phage	1.2e-232	66.6
WP_122381433.1\|19220_19580_-\|terminase	P27 family phage terminase small subunit	NA	NA	NA	NA
WP_172418989.1\|19709_20072_-	HNH endonuclease	A0A0C5AFD8	Paenibacillus_phage	4.8e-27	58.4
WP_172418990.1\|20293_21424_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_172418991.1\|21605_22082_-	DUF4065 domain-containing protein	M9QX37	Staphylococcus_phage	4.2e-15	37.5
WP_172418656.1\|22556_23300_-	hypothetical protein	D2XR29	Bacillus_phage	8.6e-39	39.6
WP_172418975.1\|23841_24237_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_172418992.1\|24250_24718_-	hypothetical protein	A0A2P1JU01	Anoxybacillus_phage	2.2e-08	33.6
WP_172418993.1\|24836_25289_-	ArpU family transcriptional regulator	S6AVV9	Thermus_phage	8.2e-69	90.6
WP_172418994.1\|25379_25634_-	hypothetical protein	A0A1L2K2L4	Aeribacillus_phage	6.7e-28	69.7
WP_172418995.1\|25769_26057_-	hypothetical protein	S6C473	Thermus_phage	1.2e-17	33.8
WP_172418996.1\|26095_26416_-	hypothetical protein	E5DV93	Deep-sea_thermophilic_phage	2.7e-42	82.5
WP_172418997.1\|26412_26568_-	hypothetical protein	NA	NA	NA	NA
WP_172418998.1\|26723_26912_-	hypothetical protein	NA	NA	NA	NA
WP_172418999.1\|27015_27486_-	single-stranded DNA-binding protein	A6M990	Geobacillus_virus	1.8e-50	63.0
WP_172419000.1\|27503_27671_-	hypothetical protein	NA	NA	NA	NA
WP_172419001.1\|27856_28579_-	HNH endonuclease	A0A0A0RNS8	Bacillus_phage	6.4e-31	40.0
WP_172419002.1\|28529_29075_-	HNH endonuclease	A0A0U4JIL0	Bacillus_phage	5.1e-33	56.2
WP_172419003.1\|29071_29521_-	hypothetical protein	NA	NA	NA	NA
WP_172419004.1\|29504_30755_-	DNA helicase	A0A0U4B0A1	Bacillus_phage	7.8e-77	38.4
WP_061567270.1\|30754_31027_-	hypothetical protein	Q38151	Bacillus_phage	7.7e-06	38.8
WP_172419005.1\|31032_31803_-	DnaD domain protein	A0A0U4JX08	Bacillus_phage	2.3e-42	57.9
WP_172419006.1\|31795_32008_-	hypothetical protein	E5DV81	Deep-sea_thermophilic_phage	4.0e-26	80.0
WP_172419007.1\|32000_32144_-	hypothetical protein	NA	NA	NA	NA
WP_172419008.1\|32140_32737_-	ERF family protein	A8ASN3	Listeria_phage	2.1e-27	49.6
WP_172419009.1\|32733_33213_-	siphovirus Gp157 family protein	E5DV79	Deep-sea_thermophilic_phage	6.4e-72	91.2
WP_172419010.1\|33292_33490_-	hypothetical protein	A6M980	Geobacillus_virus	7.8e-32	93.8
WP_172419011.1\|33482_33845_-	hypothetical protein	NA	NA	NA	NA
WP_172419012.1\|33959_34256_-	hypothetical protein	E5DV77	Deep-sea_thermophilic_phage	3.4e-15	54.7
WP_171661430.1\|34252_35029_-	hypothetical protein	NA	NA	NA	NA
WP_172419013.1\|34994_35936_-	DUF3102 domain-containing protein	D2XQ12	Bacillus_virus	1.2e-34	55.4
WP_172419014.1\|35950_36382_-	hypothetical protein	NA	NA	NA	NA
WP_172419015.1\|36399_36579_-	hypothetical protein	A6M976	Geobacillus_virus	1.2e-23	93.2
WP_013524452.1\|36808_37027_-	XRE family transcriptional regulator	A6M975	Geobacillus_virus	1.2e-28	100.0
WP_172419016.1\|37229_37910_+	helix-turn-helix domain-containing protein	A6M973	Geobacillus_virus	2.6e-119	95.6
WP_172419017.1\|37980_39372_+	recombinase family protein	A6M972	Geobacillus_virus	2.2e-250	94.6
WP_172419018.1\|39487_39691_-	helix-turn-helix domain-containing protein	A6M9A5	Geobacillus_virus	7.0e-28	89.2
WP_172419022.1\|39680_40094_-	hypothetical protein	A6M9A4	Geobacillus_virus	4.1e-67	90.7
WP_172419019.1\|40323_40503_-	hypothetical protein	A6XML5	Bacillus_virus	1.6e-20	92.9
WP_172418632.1\|40517_40916_-	hypothetical protein	A6XML4	Bacillus_virus	2.3e-59	94.7
WP_172418633.1\|40928_41519_-	replication-relaxation family protein	B3RH37	Bacillus_virus	2.9e-98	90.3
WP_172418634.1\|41454_42786_-	cell division protein FtsK	B3RH36	Bacillus_virus	4.5e-208	81.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_AP022558

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 4255

uncultured_Mediterranean_phage(100.0%)

integrase

attL 1409:1423|attR 8004:8018

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1409:1423	attL	NA	NA	NA	NA
WP_172418848.1\|1468_1636_+	hypothetical protein	NA	NA	NA	NA
WP_172418849.1\|1760_2294_+	hypothetical protein	NA	NA	NA	NA
WP_172418850.1\|2418_3252_+	hypothetical protein	NA	NA	NA	NA
WP_172418851.1\|3322_4255_-\|integrase	tyrosine-type recombinase/integrase	A0A1B1IQT7	uncultured_Mediterranean_phage	4.1e-14	34.2
8004:8018	attR	NA	NA	NA	NA

DBSCAN-SWA_2

8062 : 8689

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418967.1\|8062_8689_+	antirestriction protein ArdA	A0A142F1K6	Bacillus_phage	1.2e-12	30.2

DBSCAN-SWA_3

16198 : 38324

Bacillus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418862.1\|16198_16579_-	DUF2493 domain-containing protein	A0A218KC50	Bacillus_phage	3.8e-35	60.3
WP_172418863.1\|16575_20259_-	DNA polymerase III subunit alpha	Q8W6C3	Saccharomonospora_phage	3.8e-180	35.8
WP_172418864.1\|20463_20748_-	hypothetical protein	NA	NA	NA	NA
WP_172418865.1\|21049_21433_-	hypothetical protein	NA	NA	NA	NA
WP_172418866.1\|21840_22215_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_172418867.1\|22411_22918_-	type II toxin-antitoxin system PemK/MazF family toxin	NA	NA	NA	NA
WP_172418868.1\|23056_24964_-	VWA domain-containing protein	L7TNG1	Rhizobium_phage	2.6e-07	24.6
WP_172418869.1\|25000_26539_-	MoxR family ATPase	NA	NA	NA	NA
WP_172418870.1\|26661_28092_-	DUF3854 domain-containing protein	A0A2R3UAP7	Myoviridae_environmental_samples	1.7e-06	32.5
WP_172418871.1\|28157_28589_-	single-stranded DNA-binding protein	A0A0A8WIG9	Clostridium_phage	1.1e-06	34.3
WP_172418872.1\|28769_29237_+	hypothetical protein	NA	NA	NA	NA
WP_172418873.1\|29223_30573_+	hypothetical protein	NA	NA	NA	NA
WP_172418874.1\|30711_30999_-	hypothetical protein	NA	NA	NA	NA
WP_172418875.1\|30995_31232_-	hypothetical protein	NA	NA	NA	NA
WP_172418876.1\|31266_32061_-	hypothetical protein	A0A1W6DXE2	Sphingobium_phage	7.5e-09	26.9
WP_172418877.1\|32227_32587_-	hypothetical protein	NA	NA	NA	NA
WP_172418878.1\|32669_34232_-	S8 family peptidase	A0A217EQY2	Bacillus_phage	1.2e-39	40.1
WP_172418879.1\|34448_34967_+	hypothetical protein	NA	NA	NA	NA
WP_172418880.1\|35056_35482_-	hypothetical protein	NA	NA	NA	NA
WP_172418881.1\|35690_38324_-	M23 family metallopeptidase	A0A7K9	Microcystis_virus	6.1e-23	51.0

DBSCAN-SWA_4

44998 : 45634

uncultured_Caudovirales_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418886.1\|44998_45634_-	sigma-70 family RNA polymerase sigma factor	A0A2H4JC68	uncultured_Caudovirales_phage	4.9e-11	30.2

DBSCAN-SWA_5

51037 : 54238

Bacillus_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418892.1\|51037_54238_-	hypothetical protein	G3MAG7	Bacillus_virus	8.0e-09	33.8

DBSCAN-SWA_6

66221 : 71866

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418902.1\|66221_68312_-	DNA topoisomerase 3	A0A1X9I6W8	Streptococcus_phage	8.6e-44	29.7
WP_172418903.1\|68361_68898_-	signal peptidase I	NA	NA	NA	NA
WP_172418904.1\|69634_71866_-	ATP-dependent RecD-like DNA helicase	A0A0H3UZA5	Geobacillus_virus	5.5e-65	29.0

DBSCAN-SWA_7

100365 : 101478

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418931.1\|100365_101478_+	DNA (cytosine-5-)-methyltransferase	Q77YW9	Bacillus_phage	1.7e-70	37.5

DBSCAN-SWA_8

106278 : 108537

Acinetobacter_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418938.1\|106278_108537_+	N-6 DNA methylase	J7I0U9	Acinetobacter_phage	2.0e-107	34.3

DBSCAN-SWA_9

112521 : 115757

Geobacillus_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418946.1\|112521_112902_+	HNH endonuclease	A6M989	Geobacillus_virus	8.5e-27	47.0
WP_172418947.1\|112915_113551_+	hypothetical protein	NA	NA	NA	NA
WP_172418948.1\|113635_113842_+	hypothetical protein	NA	NA	NA	NA
WP_172418949.1\|113992_114481_+	hypothetical protein	NA	NA	NA	NA
WP_172418950.1\|114509_114707_+	hypothetical protein	NA	NA	NA	NA
WP_172418951.1\|114734_115757_-	DUF262 domain-containing protein	A0A0K2FMC2	Brevibacillus_phage	1.5e-41	34.1

DBSCAN-SWA_10

119357 : 122423

Bacillus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418956.1\|119357_119705_+	hypothetical protein	A0A142F168	Bacillus_phage	8.9e-15	39.8
WP_172418957.1\|119734_120016_+	hypothetical protein	NA	NA	NA	NA
WP_172418958.1\|120049_120616_-	adenine-specific DNA methylase	A0A2H4IZ57	uncultured_Caudovirales_phage	4.5e-48	54.6
WP_172418959.1\|120834_121956_+	C40 family peptidase	A0A1V0DZX6	Clostridioides_phage	2.3e-27	49.1
WP_172418974.1\|122003_122423_+	adenine methyltransferase	S5MUL8	Brevibacillus_phage	1.4e-54	70.9

DBSCAN-SWA_11

125600 : 126695

Bathycoccus_sp._RCC1105_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172418965.1\|125600_126695_+	hypothetical protein	E5ERA2	Bathycoccus_sp._RCC1105_virus	2.8e-06	23.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP022557

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<