CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP049867	Nocardioides sp. HDW12B chromosome, complete genome	15 crisprs	csa3,DEDDh,DinG,cas4,WYL	3	1	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP049867_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_1

64829-64935

Orphan

Consensus_repeat	Method
TCCCGGTGGTCGAGCAGCGAGCGCCAGCGAGCGTCGTCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_1

>merge|NZ_CP049867|1|64829-64935|CRISPRCasFinder
TCCCGGTGGTCGAGCAGCGAGCGCCAGCGAGCGTCGTCGAGACCCAGTCCCGGTGGTCGAGACATGGTCCCGGTGGTCGAGCAGCGAGCGCCAGCGAGCGTCGTCGA

>NZ_CP049867|1|1|64829-64935|CRISPRCasFinder
TCCCGGTGGTCGAGCAGCGAGCGCCAGCGAGCGTCGTCGA	GACCCAGTCCCGGTGGTCGAGACATGG
TCCCGGTGGTCGAGCAGCGAGCGCCAGCGAGCGTCGTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166083671.1\|70998_74592_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|143636
NZ_CP049867.1\|WP_166083674.1\|75586_76798_+\|formaldehyde-dehydrogenase,-glutathione-independent	unknown	unknown	gnl\|CDD\|274314
NZ_CP049867.1\|WP_166083659.1\|58071_58359_+\|DUF2516-family-protein	unknown	unknown	gnl\|CDD\|378483
NZ_CP049867.1\|WP_166083673.1\|75021_75468_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP049867.1\|WP_166083669.1\|69080_70412_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340878
NZ_CP049867.1\|WP_166083670.1\|70487_70844_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380343
NZ_CP049867.1\|WP_166083658.1\|56023_56611_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319971
NZ_CP049867.1\|WP_166083664.1\|62318_64091_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP049867.1\|WP_166083667.1\|65992_67246_-\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|236985
NZ_CP049867.1\|WP_166083668.1\|68214_68835_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP049867.1\|WP_166089451.1\|67313_67760_+\|RNase-III-inhibitor	unknown	unknown	gnl\|CDD\|394878
NZ_CP049867.1\|WP_166089448.1\|56728_57076_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP049867.1\|WP_166083663.1\|61513_62314_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166089450.1\|65457_65748_-\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198403
NZ_CP049867.1\|WP_166083662.1\|60437_61301_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NZ_CP049867.1\|WP_166083661.1\|59457_60441_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NZ_CP049867.1\|WP_166083675.1\|76895_77474_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166083657.1\|54319_56005_+\|DUF4012-domain-containing-protein	unknown	unknown	gnl\|CDD\|379067
NZ_CP049867.1\|WP_166083666.1\|64156_64774_+\|calcium-binding-protein	unknown	unknown	gnl\|CDD\|380205
NZ_CP049867.1\|WP_166083660.1\|58757_59387_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166083671.1\|70998_74592_-\|AAA-family-ATPase	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	3.26011e-51
NZ_CP049867.1\|WP_166083674.1\|75586_76798_+\|formaldehyde-dehydrogenase,-glutathione-independent	gnl\|CDD\|274314	TIGR02819, formaldehyde_dehydrogenase_glutathione-independent, formaldehyde dehydrogenase, glutathione-independent. Members of this family represent a distinct clade within the larger family of zinc-dependent dehydrogenases of medium chain alcohols, a family that also includes the so-called glutathione-dependent formaldehyde dehydrogenase. Members of this protein family have a tightly bound NAD that can act as a true cofactor, rather than a cosubstrate in dehydrogenase reactions, in dismutase reactions for some aldehydes. The name given to this family, however, is formaldehyde dehydrogenase, glutathione-independent. [Central intermediary metabolism, One-carbon metabolism].	0
NZ_CP049867.1\|WP_166083659.1\|58071_58359_+\|DUF2516-family-protein	gnl\|CDD\|378483	pfam10724, DUF2516, Protein of unknown function (DUF2516). This family is conserved in Actinobacteria. The function is not known.	5.36262e-25
NZ_CP049867.1\|WP_166083673.1\|75021_75468_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.84367e-21
NZ_CP049867.1\|WP_166083669.1\|69080_70412_+\|MFS-transporter	gnl\|CDD\|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.93674e-16
NZ_CP049867.1\|WP_166083670.1\|70487_70844_+\|cupin-domain-containing-protein	gnl\|CDD\|380343	cd02213, cupin_PMI_typeII_C, Phosphomannose isomerase type II, C-terminal cupin domain. This family includes the C-terminal cupin domain of mannose-6-phosphate isomerases (MPIs) which have been classified broadly into two groups, type I and type II, based on domain organization. This family contains type II phosphomannose isomerase (also known as PMI-GDP, phosphomannose isomerase/GDP-D-mannose pyrophosphorylase), a bifunctional enzyme with two domains that catalyze the first and third steps in the GDP-mannose pathway in which fructose 6-phosphate is converted to GDP-D-mannose. The N-terminal domain catalyzes the first and rate-limiting step, the isomerization from D-fructose-6-phosphate to D-mannose-6-phosphate, while the C-terminal cupin domain (represented in this alignment model) converts mannose 1-phosphate to GDP-D-mannose in the final step of the reaction. Although these two domains occur together in one protein in most organisms, they occur as separate proteins in certain cyanobacterial organisms. Also, although type I and type II MPIs have no overall sequence similarity, they share a conserved catalytic motif.	1.11263e-51
NZ_CP049867.1\|WP_166083658.1\|56023_56611_+\|hypothetical-protein	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	3.05155e-27
NZ_CP049867.1\|WP_166083662.1\|60437_61301_+\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	1.63503e-20
NZ_CP049867.1\|WP_166083668.1\|68214_68835_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.31926e-09
NZ_CP049867.1\|WP_166089451.1\|67313_67760_+\|RNase-III-inhibitor	gnl\|CDD\|394878	cd02908, Macro_OAADPr_deacetylase, macrodomain, O-acetyl-ADP-ribose (OAADPr) family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family includes eukaryotic macrodomain proteins such as human MacroD1 and MacroD2, and bacterial proteins such as Escherichia coli YmdB; these have been shown to be O-acetyl-ADP-ribose (OAADPr) deacetylases that efficiently catalyze the hydrolysis of OAADPr to produce ADP-ribose and free acetate. OAADPr is a sirtuin reaction product generated from the NAD+-dependent protein deacetylation reactions and has been implicated as a signaling molecule. By acting on mono-ADP-ribosylated substrates, OAADPr deacteylases may reverse cellular ADP-ribosylation.	2.8295e-44
NZ_CP049867.1\|WP_166089448.1\|56728_57076_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.55725e-14
NZ_CP049867.1\|WP_166083660.1\|58757_59387_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.55538e-14
NZ_CP049867.1\|WP_166089450.1\|65457_65748_-\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198403	cd10456, GIY-YIG_UPF0213, The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1. This family contains a group of uncharacterized proteins found mainly in bacteria and several in dsDNA viruses. Although their function roles have not been recognized, these proteins show significant sequence similarities with the N-terminal GIY-YIG endonuclease domain of structure-specific endonuclease subunit SLX1, which binds another structure-specific endonuclease subunit SLX4 to form an active heterodimeric SLX1-SLX4 complex. This complex functions as a 5' flap endonuclease in yeast, and has also been identified as a Holliday junction resolvase in human.	1.01104e-28
NZ_CP049867.1\|WP_166083667.1\|65992_67246_-\|phosphoglycerate-dehydrogenase	gnl\|CDD\|236985	PRK11790, PRK11790, phosphoglycerate dehydrogenase.	0
NZ_CP049867.1\|WP_166083661.1\|59457_60441_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	8.68742e-114
NZ_CP049867.1\|WP_166083657.1\|54319_56005_+\|DUF4012-domain-containing-protein	gnl\|CDD\|379067	pfam13196, DUF4012, Protein of unknown function (DUF4012). This is a family of uncharacterized proteins found in archaea and bacteria.	1.75262e-54
NZ_CP049867.1\|WP_166083666.1\|64156_64774_+\|calcium-binding-protein	gnl\|CDD\|380205	NF033203, entero_EhxA, enterohemolysin EhxA. Members of this family are the RTX toxin called enterohemolysin or EhxA, because it is found in enterohemorrhagic Escherichia coli (EHEC) strains such as O157:H7.	1.07061e-13
NZ_CP049867.1\|WP_166083664.1\|62318_64091_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.83585e-97

>NZ_CP049867.1|WP_166083666.1|64156_64774_+|calcium-binding-protein
MRSTRILAGVASACGLLMVAASPAQAEFIGGTDGADTLVGTRFYDAMLGRHGDDVLRSLRGPDEVYGQGENDRLELGYGDDFGHGGSGNDVIAAGPGADYAVAGGGTDTLYGGPGGDALWSGAGSTTMVGGDGRDRIFMEPGNHEASGGDGDDVIRVLADATDARDDIACGPGEDTVRYLEDFGEPGPTDPTDVLTGCENVLAAP
>NZ_CP049867.1|WP_166083664.1|62318_64091_+|serine/threonine-protein-kinase
MSLNLAPGSVLGRYRISGTLGRGGMGVVYAAVREDLDRKVAVKVLAPELTGDPAFRRRFAREAQTLSEVYSPHIIDIYEHGEQDGCLFIATPLVNGGDLRGLLTEHGGLPPLEALDLVQQVASALADAHAAGVIHRDIKPSNVLLHRSPDGERFAYLADFGIARSLDDEATLTGRLSGTRGYLAPECHAGARSTVASDVYAVGCLLVATLTGAPPYDGTDVQVAMQHLRGPVPHYPEPGVVAGAVNAILQRAMAKDPRERYDSAAELRADLRRAWALAQSHPGEVLDADSLTSDPEPTAPGLAPLPPYRSSGTQRRRPGARPQARRPRGARAVWTATLVAAAVVAAVLVPWEGFVDLRAEPGLDCVAADSAGTVTRLGTAGGAVRGAGRSGGATGADCQQASSSTPTPRGKHTCWDGTPVQHRVDCLEPMGLRGLLWVFPSLRRDLGRCEQLVDPTVDPSLRQWRCTVPLGSDDPVGAVTYSEWREPRDAWEYFDGRFARPAVNFRVGDKAAGYRWWSETRDEAGRLAMAVAYLQIGFSATMVSRTSEGLDRVCSTVRARSPRTFYGEPIVCTRQTPRPPQVPGWSQNAV
>NZ_CP049867.1|WP_166083663.1|61513_62314_+|hypothetical-protein
MHLGQQAAKRSTHLEYSVLDGEARSVDLAAGEPWTFGRSPGCSETLALPALSRVSLVLQHVEPGLLRVVSRQSNHGRVLVRSEDEVEQHVIGLGSGPVHLAGGNYTLKVELPPVVLRLHAAVPLPVGDARSVPRPRGVSPAAERTGLSWEPRPSASAGPDWIAVTALAVTLARYPRLRQPGPGEPGAGATRTSETLRRAVALWCGHTSRYWVNERLKEAAEAADLDVKDGGDRVAAVVAHYAPMFPDVVLRGVRDDLLRLGLQEAG
>NZ_CP049867.1|WP_166083662.1|60437_61301_+|ABC-transporter-permease
MTTTTTPAHLGTQPAEGREPLSPPSYAAACLLVVRRNLLHIKRMPELLLDVTIQPVMFVLLFAFVFGGAIAIPGSDVEYREYLIPGIMAQTMVFSSFIVALGLVNDLQKGFVDRLKSLPIARSSILVGRSISSILHSSIGITVMALTGLAIGWRMHEGVGKAVLAFGLFLLVGFAMIWVGILVGSTFNSVEAVNGFMFTVMFPLTFLANTFAPPEAMPDVLRVIAEWNPVSSLTQAARELWGNGPVASPDAQLPLQHPVLFTIGWALLITAVIAPLALRQFRNKARD
>NZ_CP049867.1|WP_166083661.1|59457_60441_+|ATP-binding-cassette-domain-containing-protein
MTTYAVEADDLVKKFGDTLAVDHVSFQVPEGSVMGVLGPNGAGKTTTVRMLTTMSRPTSGTGRVAGHDIVGDPEAVRRSMGLTGQSATVDELLTGRENIRLIGRFAGLSSAAVKRVGDDLLERFSLTDAADRTAKTYSGGMRRRLDLAVSLVATPPVLFLDEPTTGLDPRSRTELWEVLRGLVHDGTTLLLTTQYLEEADQLADDIIVIDKGRIIAQGTPTQLKQQSGQASVVVHVATAADLERAAAVVRRCAPEVHVDDASRRITAKADGLGDMILISEAINADGVDVDDIGLARPSLDDVFLHLTGHRAEDETDGSAELIEEGVR
>NZ_CP049867.1|WP_166083660.1|58757_59387_+|TetR/AcrR-family-transcriptional-regulator
MTTRTARGTARTRLLEAALRVIRERGLHATTVDDLCAAAGVTKGAFFHHFASKDELAVAAADHWSSSTGAMFAASDFRALTTPWERIMGYLELRENLLDGDVAEFTCLVGTMVQEAYATHPEVRDACRASILGHAGTLVSDFGDLIATYGAPASVTATGLAEHTQTVLQGSFVLAKATDDASAVIVAIDHLRRYLELLFPAAAAPKETP
>NZ_CP049867.1|WP_166083659.1|58071_58359_+|DUF2516-family-protein
MDLFALPSLILLVVKLATFVLQAFAFVDALTHRAEAYVAADKLTKPAWCIILGVATASQLVFRDPINLFNLAGTIAALVYVLDVRPTLRELTRRR
>NZ_CP049867.1|WP_166089448.1|56728_57076_+|helix-turn-helix-transcriptional-regulator
MGSLGDYLREQRLANKLSLRQLADAAGVSNPYLSQIERGLRRPSAEVLQSIATALRISAETLYVRAGILSPDDSEIRSVELAILADPGLSDRQKQSLVDIYRSFRASNDTTPEGD
>NZ_CP049867.1|WP_166083658.1|56023_56611_+|hypothetical-protein
MSQAGPYRVLTVCLGNICRSPLAERLLATRLNGAAEGGFAVSSAGVIGMIGRSMEPAAAAQLERLGGNPSGFVARRLDVHHVRNADLVLTATVDVRRQALEEAPGALRRTFTLLEFAALCSTAGPELRGRPRELVADAAVRRATVGGQELDIPDPMGRSDRTHARVADLIDGAVETIVAALTSRGSRADGSASRG
>NZ_CP049867.1|WP_166083657.1|54319_56005_+|DUF4012-domain-containing-protein
MLFTVWQALVVKNALTDAAADLKVAAKKFGEGRDRQAAARLEAAASSASRAQRNTTGPIWWIASYLPDVGDDVEAVRTVSAVADDLLGGALPGLTEGGSAARPEAFRPVRGRFDIEGIKAAQPILASLADDVSKGNARVATLDTPGLIVPLRTRVLDLQETLELADSAARAAASAAELMPTMLGQDGKRTYLLLFQNNAEIRAQGGMPGALAIIEAEDGSVRMTRQGAPRDIGTFPRPFVDLTGEEVELFTTRAAIYPQDTVFIPDFPRSSSIVSQMWERRQPEELDGVLSVDPVALSYLLRATGPVRLAGGQVVTATDARDYLMREVYLDVRGEKAQNTIFADTARGAFDALTGGSVEPAALLRAVAEATTERRIMVWSERSEEQDLLAGTAIGGDLPVAANERPEVGVYVNDSAADKLSAYFDYRVDVSARTCSADRQTLDVQVTMTSTVPAGVTLPTSVVGPPTNPTRPGDILNSVYLYAPPGGYIVSADLDGQEPPLGDYTYRGRDVGAVTVGLERGETRTLSYEVRTGEGETGDPRLITTPGALGSGMGDVSATAC
>NZ_CP049867.1|WP_166089450.1|65457_65748_-|GIY-YIG-nuclease-family-protein
MAWVYILRCADDSYYVGSTTNLEVRVYEHQQGRGAAYTRRRLPVELAWSQECESVAEAFGLEKQYQNWSRAKREALIKGEYDALPRLARGHNRRPL
>NZ_CP049867.1|WP_166083667.1|65992_67246_-|phosphoglycerate-dehydrogenase
MSTLFPPSGCRSRRDYSLGVRALLLENLHPLATKILTDAGHEVDARSGAMDEEELLSSLGEVDLLGIRSKTVVTERVLAAHPHLTAIGAFCIGTNQIDLAAAAERGIAVFNAPFSNTRSVVELAIAEIIAMGRQLTEKNKAMHAGVWDKSAVGSHEVRGRKLGIVGYGNIGSQLSVVAETLGMHVYFYDAEDKLALGNARRCGSLQELLETVETVTLHVDGRLGNAGIFGAEQFAMMRPRSLFLNLSRGFVTDYDALAESLKSGHIAGAAIDVFPAEPKHQGDPFESPLQGIPNVILTPHVGGSTEEAQADIGRFVGGKLRDYVALGSTTLSVNLPGLTPTTAPFAQRIAHLHENNPGVLGCINQRLAEHHINIIGQVLATRGHQGYVVTDTDSPVTPEALTALGDLDGTIRMRSLT
>NZ_CP049867.1|WP_166089451.1|67313_67760_+|RNase-III-inhibitor
MRGGGGVDGAIHAAAGRGLLAECVERFPDGLATGAAGWTTGHRLPARWVVHVVGPVHDGTGRNRDQLVSCYTSALAVADELVEQHGLASFTMAFPLVSAGVYGWPVEDAVRVQVETLSTTPTAVDRCVLVGFSESTTRLLQAAADARS
>NZ_CP049867.1|WP_166083668.1|68214_68835_+|TetR/AcrR-family-transcriptional-regulator
MSRMSVEQRRRLLIDAAINVMSREGVANTGTRAIVAEADMAIGVFHYCFRSKDELVIEVLRSINKRSFAAAGDILNYSTDPSEVIQRGLEAYWNHVEDHPSERMLLFELTHYSLRNATERHAAQEQYGTYITGMQRFLNAVGELGGLTWRSDVEDLARYTVATLQGISIQWLVNRDGKHARAMLSHIASHLLDDAGLERTGWVPTE
>NZ_CP049867.1|WP_166083669.1|69080_70412_+|MFS-transporter
MSATSRSDAARVAVVLGLLFGLTGMGSAAAAIAVVPMAEAYGVSDGAATWTISLYALMLGIGTAVYGRIADLSGPRTPMTVGITLMSVGALLAALAPSFPIHLVGRLAQGAGAAAVPTLGAAVLSARYSGDLKSTALVKLASIAAAVTSLGPLAGGIVIDTLSWRFAIALPMLGLLVLPFIWHAMHVGGTGARLDFIGAALTALAAGGAVLLVQSPSTGVVVAVAGGLLLALGVPAVIAWVRRHPGGFLPREVIGNPVVVRSAFAAAAVPASWFALLIAVPAVLLDRGWETWAVGLTLVPSGVVSLLMPRVVGPLLTRLEPSGSLMLASVISVGSLGLAGLGAGLGSPPLLVVAVVFVTVAFGIGQPALSAAVGGAVEESVRGVALGVATLVFMVGGSIGSAVVGGLGHVLGLGPAIGALALLPLVGVLVVAPTRRAVSEPVV
>NZ_CP049867.1|WP_166083670.1|70487_70844_+|cupin-domain-containing-protein
MALDFEERPWGSWHVIDVDRGYKVKRIHVKPGARLSYQTHEHRSEHWVVVFGIATCVIDGVTTTAGPGHSVDVPLGAKHRLANESTEELVIVEVQRGSYTGEDDICRLEDDYGRNEVH
>NZ_CP049867.1|WP_166083671.1|70998_74592_-|AAA-family-ATPase
MALDEGGYPVAGCSGCGTQLPDGARFCLECGTPQSVSCAGCAAPLPPSAKFCMECGTPTGAGPGAPRTTPSEQTGASSRRTTSILFGDLVGFTTLSETRDSEDVRELLSRYFDECRQIVARYGGTVEKFIGDAVMAVWGVPTAHEDDAERAVRAGLELVAAVREFGEDVGAPSLALRVGVVTGEVAVTTGATQQGMVAGDAVNTAARVQSAAQPGSVFVDETTRLLTTAAITYADAGSHALKGKADPVPLWSVRAVVAATGGAQRADGLEAPLVGRDRELRLVKELFHHAEESGRPALLVIDGEPGVGKSRLAWEFEKYVDGLNDLVRWHSGRCVAYGEGVAYFALAEAVRGRLLAGLDDAEQDAPTEQLLAWALERHVPDTSERDWLRDRMAALLGIGAISGFPREDLFSAWTVFLERVADDEVLTLVIDDAQHADDGLLGFLEHLITVASFPCFVMVLTRPGLLERRTSLATHRRATVIHLPTLSDRDVAALLDGLVAGLPDEVRDQLVARSDGIPVFAVETVRSLIDRDLVVPRGGQYVLADGARLDLDSLAAPASLQALIAARLDALSTEQRLVVDRGSVLGTTFAPDALADLCPEVADTATVLGSLVRLQILSQDASRMSAGYGNFRFVQSAVRQVAYGVLSRRDRRAIHLAVLAQMVTRGETGEDTAAIRAQHLLDALEAGSGPDDADLRARALDELTRASTRARGLGSPTEAVRHLRTALPLANDPADRAQVLLLLGRAEADAGDFDQAVAHAREAHDLFVTLDDRPSAGLAVATWGESVLNGARDSEAALALCEPWWEELRERDDALEAKMTLTYVITRARLWTDGDIHDIIEARLALGEVEKDFGVISDGYNGLGVYYANRGLVSLSDVLLRASVELARRHHDPRAEAMALNNIAAQENPRDVPEALTSGLAAVDVALRMGHAFQIRFGLANYCIALWSAGEWDRFEPARARCSAVVEDSADDETTLALTAMLAVVRGETPTPPAQTAVERAGDDEASLAWVRFHEAAIHVSHGDLRAALASGMAGVELSFAVTGVWDDLTHLWGPAADLAVRLGDDAAVTRLVELTDDGRPRLPRGLEGHRELLRARLAARDGHVEEAESAFTRALEHYRAWGSTPSVAHAELHLGRWLEAQGRHDEAAGHLAAARSTYEELGAVTWLADVDAAEGRAASLGGRAASASERRRDLAT
>NZ_CP049867.1|WP_166083673.1|75021_75468_+|MarR-family-transcriptional-regulator
MTRFRVDDQLCFALYDASRAIVGRYREGLAQLGLTYTQYLVLLRLWETSPLTVADLGDALNLDSGTLSPLLKRLETQGLVTRRRLPTDERSVEVAVTSAGRDLKPLARRVQVDVENATGLDGESITALRDDLHELAAELRGENDELSA
>NZ_CP049867.1|WP_166083674.1|75586_76798_+|formaldehyde-dehydrogenase,-glutathione-independent
MSGNRIVVYKGPGEVAVESVDYPKLEIPAEVAQGMGIKQAAPHAVILKLVTTNICGSDQHMVRGRTTAPEGQTLGHEITGEVVEVGDDVLFVKEGDICSVPFNIACGRCRMCNEGKTGICLNVNPARAGAAYGYVDMGGWLGGQAEYVMIPFADFNLLPFPDRDAALEKILDLTMLSDIFPTGYHGAYTAGVTTGSTVYVAGAGPVGLAAAYSAQLLGAAHVIVGDMQADRLKQAESFGCSTVDLSSGNSLVDMIEQIVGEPEVDAAVDAVGFEARGHGEGASEAPATVLNDMMTVARAGASLGIPGLYVTGDPGAVDDAAKEGQIGVKLGLGWAKSHAFVTGQCPVKQYNRKLMNMILADKAHIAKAVNAKTISLDDAPRGYQEFDAGAATKYVIDPHGMVA
>NZ_CP049867.1|WP_166083675.1|76895_77474_+|hypothetical-protein
MEPLRQGDPDVVGRATAMTAVGTDVAIAVTRSAAPGPEEREYVVPLGSRALKVRWRDDGLDATAPTRSTLLPTRLRLQLGTDPGGPVLRGTATNRTPWVWTVLLVPLAAWFVVQLVDALGDGSTARTVTSGLVLLACLVGLVVAGTPRSTRHVRTLDLVDLAQALWERDPADRGRAPVRTARPPRRSRTRRR

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Crispr_ID: NZ_CP049867_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_2

103640-103725

Orphan

Consensus_repeat	Method
TTCACTGGGTACCTAGTGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_2

>merge|NZ_CP049867|2|103640-103725|CRISPRCasFinder
TTCACTGGGTACCTAGTGAAACCGGCGCTTCCCGCACGAAACTTCGTTCGGGAAGCGCCAAATTCACTAGGTACCTAGTGAAACCG

>NZ_CP049867|2|2|103640-103725|CRISPRCasFinder
TTCACTGGGTACCTAGTGAAACCG	GCGCTTCCCGCACGAAACTTCGTTCGGGAAGCGCCAAA
TTCACTAGGTACCTAGTGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166089458.1\|101754_103086_+\|D-inositol-3-phosphate-glycosyltransferase	unknown	unknown	gnl\|CDD\|132490
NZ_CP049867.1\|WP_166083685.1\|92118_93492_-\|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl\|CDD\|234968
NZ_CP049867.1\|WP_166083701.1\|110382_110883_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|178851
NZ_CP049867.1\|WP_166089460.1\|103120_103627_+\|YbjN-domain-containing-protein	unknown	unknown	gnl\|CDD\|371210
NZ_CP049867.1\|WP_166083687.1\|95124_95409_+\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|380141
NZ_CP049867.1\|WP_166083690.1\|97276_98044_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP049867.1\|WP_166083689.1\|96217_97066_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382
NZ_CP049867.1\|WP_166083698.1\|108816_109533_-\|UbiA-family-prenyltransferase	unknown	unknown	gnl\|CDD\|260119
NZ_CP049867.1\|WP_166083695.1\|106475_107297_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP049867.1\|WP_166083688.1\|95457_96147_-\|amino-acid-racemase	unknown	unknown	gnl\|CDD\|224707
NZ_CP049867.1\|WP_166083696.1\|107410_108163_-\|phosphoglyceromutase	unknown	unknown	gnl\|CDD\|184519
NZ_CP049867.1\|WP_166083692.1\|98852_101792_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341246
NZ_CP049867.1\|WP_166083702.1\|110966_112631_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239028
NZ_CP049867.1\|WP_166083697.1\|108167_108767_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166083694.1\|105753_106410_+\|phosphate-signaling-complex-protein-PhoU	unknown	unknown	gnl\|CDD\|273990
NZ_CP049867.1\|WP_166083691.1\|98040_98715_+\|sterol-desaturase-family-protein	unknown	unknown	gnl\|CDD\|377224
NZ_CP049867.1\|WP_166083686.1\|93608_94373_+\|NAD-dependent-deacetylase	unknown	unknown	gnl\|CDD\|238698
NZ_CP049867.1\|WP_166089463.1\|104412_105597_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|274368
NZ_CP049867.1\|WP_166083699.1\|109713_110199_+\|CarD-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224248
NZ_CP049867.1\|WP_166083693.1\|103738_104416_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166089458.1\|101754_103086_+\|D-inositol-3-phosphate-glycosyltransferase	gnl\|CDD\|132490	TIGR03449, mycothiol_MshA, D-inositol-3-phosphate glycosyltransferase. Members of this protein family, found exclusively in the Actinobacteria, are MshA, the glycosyltransferase of mycothiol biosynthesis. Mycothiol replaces glutathione in these species.	0
NZ_CP049867.1\|WP_166083685.1\|92118_93492_-\|cation:dicarboxylase-symporter-family-transporter	gnl\|CDD\|234968	PRK01663, PRK01663, C4-dicarboxylate transporter DctA; Reviewed.	8.84208e-175
NZ_CP049867.1\|WP_166083701.1\|110382_110883_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|178851	PRK00084, ispF, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed.	1.87077e-74
NZ_CP049867.1\|WP_166089460.1\|103120_103627_+\|YbjN-domain-containing-protein	gnl\|CDD\|371210	pfam10722, YbjN, Putative bacterial sensory transduction regulator. YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabilizer for some other unstable proteins. This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.	3.96936e-18
NZ_CP049867.1\|WP_166083687.1\|95124_95409_+\|DUF559-domain-containing-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	4.68086e-05
NZ_CP049867.1\|WP_166083690.1\|97276_98044_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	6.20168e-35
NZ_CP049867.1\|WP_166083689.1\|96217_97066_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	2.20781e-64
NZ_CP049867.1\|WP_166083698.1\|108816_109533_-\|UbiA-family-prenyltransferase	gnl\|CDD\|260119	cd13956, PT_UbiA, UbiA family of prenyltransferases (PTases). Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.	2.06118e-10
NZ_CP049867.1\|WP_166083695.1\|106475_107297_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	2.74967e-08
NZ_CP049867.1\|WP_166083688.1\|95457_96147_-\|amino-acid-racemase	gnl\|CDD\|224707	COG1794, RacX, Aspartate racemase [Cell envelope biogenesis, outer membrane].	3.64292e-87
NZ_CP049867.1\|WP_166083696.1\|107410_108163_-\|phosphoglyceromutase	gnl\|CDD\|184519	PRK14120, gpmA, phosphoglyceromutase; Provisional.	1.35954e-170
NZ_CP049867.1\|WP_166083692.1\|98852_101792_+\|AMP-binding-protein	gnl\|CDD\|341246	cd05922, FACL_like_6, Uncharacterized subfamily of fatty acid CoA ligase (FACL). Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	4.799e-99
NZ_CP049867.1\|WP_166083702.1\|110966_112631_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239028	cd02110, SO_family_Moco_dimer, Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). .	3.62423e-66
NZ_CP049867.1\|WP_166083694.1\|105753_106410_+\|phosphate-signaling-complex-protein-PhoU	gnl\|CDD\|273990	TIGR02135, Uncharacterized_protein, phosphate transport system regulatory protein PhoU. This model describes PhoU, a regulatory protein of unknown mechanism for high-affinity phosphate ABC transporter systems. The protein consists of two copies of the domain described by pfam01895. Deletion of PhoU activates constitutive expression of the phosphate ABC transporter and allows phosphate transport, but causes a growth defect and so likely has some second function. [Regulatory functions, Other, Transport and binding proteins, Anions].	5.96152e-54
NZ_CP049867.1\|WP_166083691.1\|98040_98715_+\|sterol-desaturase-family-protein	gnl\|CDD\|377224	pfam04116, FA_hydroxylase, Fatty acid hydroxylase superfamily. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.	2.38225e-14
NZ_CP049867.1\|WP_166083686.1\|93608_94373_+\|NAD-dependent-deacetylase	gnl\|CDD\|238698	cd01407, SIR2-fam, SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.	1.46197e-88
NZ_CP049867.1\|WP_166089463.1\|104412_105597_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	4.33078e-73
NZ_CP049867.1\|WP_166083699.1\|109713_110199_+\|CarD-family-transcriptional-regulator	gnl\|CDD\|224248	COG1329, COG1329, Transcriptional regulators, similar to M. xanthus CarD [Transcription].	1.64559e-62
NZ_CP049867.1\|WP_166083693.1\|103738_104416_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.48947e-93

>NZ_CP049867.1|WP_166089460.1|103120_103627_+|YbjN-domain-containing-protein
MREQAVATVRAVLADNELEHTEVSPGVFSVTLPGEKKLQTPCRLDVGPHALGVHAFVARHPDENHARVYRWMLERNLKLYGVAFAVDHHGDIYLDGRLPLSSVTPEELDRLLGAVLSYADESFNTLLELGFGSSIRKEWEWRISRGESTRNLDAFRGWLEATGTPTEQ
>NZ_CP049867.1|WP_166089458.1|101754_103086_+|D-inositol-3-phosphate-glycosyltransferase
MQRPPVRPESSAEPLDLSVARSPRRVAMISLHTSPLDQPGVGDAGGMNVYVLELSRRLAERNLEVEVYTRATSSTMDPVVEAAPGVRVHHVAAGPYEGLGKEELPAQLCVFARHLLRAEAGHEQGWFDLIHSHYWLSGQVGALVRDRWSVPLVHTMHTMAKVKNALLAEGDTPEPTARLLGEDQVVEAADMLIANTGLEAQQLIDLYAADPARVEVVHPGVDLGMFVPRPQRDARARLGLPADAIVPLFVGRLQPLKAPDVLLRAVALLVRDDPALRSRLVVPVVGGPSGSGLEHPTALADLAGELGIGDLVRFVPPVGRAELVDWYAAATVVCVPSYNESFGLVAIEASAVGTPVVAAAVGGLTTAVRDGETGLLVDGHDPADYAAALRRLVSDTAYRERLASAAALHARDFAWERTAERTLEVYRKAAHAMRHDLQDVVRA
>NZ_CP049867.1|WP_166083692.1|98852_101792_+|AMP-binding-protein
MTAAVETRPFWDLSRHAAGTALVVDGDEVGYDDLADRVTRLAARLGGTRRLVLLEAANDLDTVVGYLACLVGHHPVLVTAPGPAASAACAAYDPDVVLAGDALAEERAGTRHDLHPDLAVLLSTSGSTGSPKLVRLSRDAVAANARAIAEALAIRPDDVAAAALPLHYCYGLSVLTSHLQVGASVLLTSASVVDPDFWREARRHRVSTVPGVPHTFDLLDRAGFADLDLPSLRYLTCAGGRLPATTATRYAELGLRRGFDLFLMYGATEATARMAVLPPDRVLTGPTLLGDPVPGGSFAVRPVAGLPVGQSGLGAPDVDGEPVGELVFRGENVMLGYAETPADLARGREVDELRTGDLVRRTPDGLEVVGRLGRIAKVFGLRIDLDRVEARLRAAGIVGYAADAGDRVVVAVDRSARPLSDADLERVRDAAEGAGVPRAGCLVVELDSVPRRGNGKVDHAAIAAAGHRARADAVAGVHATPGRDAAVPDAPAQAGPRPDAAVSDARALAGPGPDTTPRAGRHAAATAGTGPDVAARVGEVLAAVGRGPLRPEDTFVSRGGDSLSYVETSLRLERVLGHLPVRWHLLTAAELAGRAAGRTVERAALPGSAPHGPGGARAARPDGRTGATSARRGDPATRRTRSVETNVLLRALAIVLIVGSHSNLFMVLGGAHVLVGLAGFNLARFHLVDRERVDRVRSMLTSVARVAVPTVLWLTFAAATSAKYDWRNVVLLNGVLGTREWSEAWHYWFVEALVWTLLAVVALLAVPAVHRLERRAPFWFPVGLVVLALPARYDVGRLLDGDYIHRGHVIFWLFALGWATAQARRPLHRVVVSVLALATVPGFFEGDLAREAVVVAGLLLLVWVPSLRVPAAVARLAGTLAGASLYIYLCHWQIYPAYEFSLPWLATGLSLLAGVVFWRVTVAATPYVERGLARAGHRLGVTRVTPEVVEEIAHARPRFSPRRCLTRDATSAREARVVG
>NZ_CP049867.1|WP_166083691.1|98040_98715_+|sterol-desaturase-family-protein
MTTVLPRAQRGLSLGDAAREFARHPSPWMLGGLLVAAAAARLLLEDWRLSDLLAPAAFLALFPVVEWLVHVFVLHWRPRRLGPVTLDTQLARKHREHHASPRDVPLVFIPWQTLAGLVVVVPALALLAFPRPHQALAFVVTVAVVGLVYEWVHYLVHSDYRPRSRAYRAVHRHHRLHHFKNENYWLTVTSAHTADRIFGTDPDPADVPTSATAKDLHGLQGTGH
>NZ_CP049867.1|WP_166083690.1|97276_98044_+|FadR-family-transcriptional-regulator
MNLQPVRRHTVADDVFEQLVAEVSGLAPGESLPSERRLTEVLGVSRPVVREALQRLSHAGLVEVRQGDATTVRDFRRDGGLDLLARLLVPARGLDVAVARSIVEARHLVGPTVAELAASRPDIDDAAVRLTQLAAALRATTDPVTRQRLALEFWDVVIDAADSLVFRLMFNSLRAAYEPMLDALASLIDGADQPERYDALAAALADRDPARARAAAEDLLGPATTALLSALDDLDAPGPGAPAPAGADRDGQEDA
>NZ_CP049867.1|WP_166083689.1|96217_97066_+|methyltransferase-domain-containing-protein
MDELPEAVALTPTSFRTDHRTADAEAELASLVFVLDLQAANPAVRRLRAWARDELAARPGDTAVDVGAGTGEEVQALASLVWPTGRAVGVEPHAGLRAEAQRRAAGTSATYVDGDARALPFEDGSVDVLRCERVWQHLVDPQEAADEVARVLAPGGRVAVLDTDWSTVVGRAGDPDVQRRLNESTWRRMANPFAGRHLRAQLQRAGLTVRADIGSSALVMPDEVMASPMMVDLDLRLGVEEGVVSQDEADAYRQAVVEAAQRGEGFMAVTMFAVVGDKPGSG
>NZ_CP049867.1|WP_166083688.1|95457_96147_-|amino-acid-racemase
MLTIGLVGGMSWESSAEYYRLLNQGVEQRLGGLHSARTVMASVEFDELTRLQREERWDEVAAILGAAASGVEAAGADLVLLCTTSFHRVAEQVSAGLGVPMLHLADVVADAVAAAELQKVAFLGTAFAMGRRFFTDRLETHGISVVTPAEEDHATLDRIIYDELVHGKVLDPSRRTVVDLIGRLWDQGAEGVILGCTELEALIKQADSDLPVFPCTTVHVQAALDRALA
>NZ_CP049867.1|WP_166083687.1|95124_95409_+|DUF559-domain-containing-protein
MLLQDRGFLGRPDLVDVERRLVLEADSWEFHASKEGFRRDCERYNALVLRGWTVLRFTWWQVMHRPDYVLAALRAVVEGSDGRAVRAPELLWTA
>NZ_CP049867.1|WP_166083686.1|93608_94373_+|NAD-dependent-deacetylase
MDTLTDLLREAAVVVGFTGAGVSTESGIPDFRSPGGVWTRYDPRSFELDRYVADASVRRESWQMRREFFATSVAPNPAHRAFAALEGAGRSPGVITQNIDGLHQEAGSRRVVELHGTAREVMCLGERPVGAPDGCGWRSPYTWAFERLDAGEDDPRCPRCGGLVKSATVSFGQQLFPGVVEEAVGLVERADLLVVAGSSLQVYPAAALPLHALDHGARLVIVNDEETPFDDVADLVVRGRAGEVLGPAVTAALS
>NZ_CP049867.1|WP_166083685.1|92118_93492_-|cation:dicarboxylase-symporter-family-transporter
MSTSQDDPTNPDPSRGSSGAPKKRDKTHWLYIGVIIAVVLGIAVGFLFPDFAVKLQPLADAFIGLIKMMISPIIFCTIVLGVGSVASAAKVGKVGGLALAYFLTMSTFALAIGLVVGNIIQPGDGINLTEESAAAGAAQVAEKESTTDFILGIIPTSLFSALTDGEVLQTLLVALLFGFALQTMGRAARPVLVTIEHLQRVIFRILSMIMWTAPIGAFGAIAAVVGETGWDALQSLAMVMLAFYLTCAVFVFGVLGAILKVVTGINIWSLFKYLGREFLLILSTSSSESALPRLIAKMEHAGVEQTTVGVVVPTGYSFNLDGTAIYLTMASLFIAEALGDPLSIGEQISLLLFMIIASKGAAGVSGAGLATLAGGLASHRPEMVEGVGLIVGIDRFMSEARALTNFAGNSVATILVGHWTDSYDKDRLQRVLDGQDPFDEQTMLDDHSEAEKAVADR
>NZ_CP049867.1|WP_166083693.1|103738_104416_-|response-regulator-transcription-factor
MTRVLVVEDEESYSDALAYMLRKEGFEVSLAATGLQALEEFDRSGPDIVLLDLMLPELSGTEVCRRIRAVSNVPVIMVSAKDDEVDKVVGLELGADDYVTKPYAPRELVARIRAVLRRGNEVEAAPAALEAGPVRMDVERHLVSVNGADTPLPLKEFELLEMLLRNPGRVLTRGQLIDRVWGSDYVGDTKTLDVHVKRLRAKIEPDPANPVHLVTVRGLGYKFDA
>NZ_CP049867.1|WP_166089463.1|104412_105597_-|two-component-sensor-histidine-kinase
MLLLLGIFLGALPVLAWHASERQLRGRKPPEEPAADVVPPGVATVLNVLRSSALVVDAEDRVVQASAPAYSLGLVRDGELRNDELAALVAKVRRDGEIRQVDLDIHRTGQQPVHVNARVAALSSRLVLVLTEDRTRERRVDAIRRDFVANVSHELKTPVGALTLLAEAVREAADDPEAVQRFAARMQTEAVRLNRLVQQIIELSRLQGDEALERPAMVPVDRVVERSIDFNEIEATAKGIEVVYDGRRGLSALGNPDQVSLAVSNLVANAIAYSPEGSRVVVSALQQELMVDITVTDEGIGIPRAELDRIFERFYRVDPARHRSTGGTGLGLSIVKHVAATHGGEVKVWSEPGKGSSFTLRLPRHTATPAPAPGPAPDRASAVPTPVPSVKESS
>NZ_CP049867.1|WP_166083694.1|105753_106410_+|phosphate-signaling-complex-protein-PhoU
MRTAYHDQLDAIVDDLVRLTGMVQDATSQATTALLSADAGVAEQVLRGDAAIDALRNDIEGRAFELLALQQPVAGDLRMLIATVRMVADLERMGDLAVHVAKVAQLRVPEVAVPPDLIPTVERMAAVAVHMIGSVAEVIKNRDVDAARSVESDDEEMDELRRRSFRLMLGESWAYGVEPAIDNALLGRYYERIADHAVSLARRVVYLVTGEVPTALDG
>NZ_CP049867.1|WP_166083695.1|106475_107297_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MDSATPAEPGLDFVEEFASAAEWFATHLGRTSARAPVPACPDWSVLDLVAHLGNVHAWAATVVETGAKAEQLDDRPSSARSRRVSEWYLAKAEDLYEVLRAADPSAPCWTFVDDAGTAAFWARRQAHETVVHGFDLAVAGDHEPRVPPRLAVDGVSEVLEVFLGRMHRRGHPAVLHRALELRATDAEESWVLEPAPVGIPAQGASPEQREERPTTRAVPVVTRGSRDDLDRIEAPAATLLTLLWRRTRPDAADVRLVGNEDRLRAFLQSRLTP
>NZ_CP049867.1|WP_166083696.1|107410_108163_-|phosphoglyceromutase
MSAPYTLVLLRHGESDWNAKNLFTGWVDVALTDKGREEAARAGRLLTEAGVLPDVLHTSLLRRAITTAQLALEEAERHWVPVRRSWRLNERHYGALQGKDKKATLEEYGEEQFMLWRRSYDTPPPALDDDNEWSQVGDPRYDLLPGELMPRTECLADVIDRMLPYWYDAIVPDLRDGRTVCVAAHGNSLRGLVKHLDGISEEEVVGLNIPTGIPLVYRLDEDLHPTERGGQYLDPDAAADAIKAVASQGR
>NZ_CP049867.1|WP_166083697.1|108167_108767_-|hypothetical-protein
MTASRLRPVAAPRSRARRLLALTLATPLLAACSVNFGAQTDQVYTPAQGVNDRSTDIDVLNALVVAESDGSGRLIAGLASQADEDVELQGVQGVEEDAEVQFGSDGGDTVVPAGGFLQLADEGSAVISATGEGVEIGDYVRLTMSFSNGDEVDLNVPVVVPGEDFADVTLPSSGSSESSSEEPSAEPSESPSESPSSEG
>NZ_CP049867.1|WP_166083698.1|108816_109533_-|UbiA-family-prenyltransferase
MSKRKRPGFALSLLRASHPGESLVIAVGVTLGAVLIGRPLREVALVFATVLLGRLTAGWLNDAADRRRDAAAGRLDKPVAQGWVDGGTVTFTVACATCVLVPLSISNGTVAGVAHLLSVLAAWAYCTRIKTTRLSFLPWAISFALLPAFLSYGGWGGGVHGGPPTVLMTVLAGLLGVGVHVILALQDLVGDNRIGLRTFPLMIALKIGAGKLLVLSGVWTVAVLGGIVAAGLGPGLTQ
>NZ_CP049867.1|WP_166083699.1|109713_110199_+|CarD-family-transcriptional-regulator
MTFTVGETVVYPNHGAAVIEDIETRTIKGEDREYLVLRIVAQQDLVVRVPACNLDLVGVRDVVDKEGLDKVFDVLRMAHAEEPTNWSRRYKANLEKLHSGDVMKVAEVVRDLWRRERDRGLSAGEKRMLAKARQILVSELALAESTNEDKAEALLDEVLAS
>NZ_CP049867.1|WP_166083701.1|110382_110883_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MDDPAVSAPLPLPRTGIGVDVHAYAEGVPMWLAGLHFEDETHGLDGHSDADVAAHAACDALFSACGLGDLGSNYGTSDPAWAGASGVALLAETARRVREAGFTIGNVAVQVIGNRPRLGPRRAEAEATLSEAAGAPVTVSATTTDGLGLTGRGEGVAAIATALVAR
>NZ_CP049867.1|WP_166083702.1|110966_112631_+|molybdopterin-dependent-oxidoreductase
MGHHGAVSPSPTPPPADARASRRTSIPGQSLLAGVLTGVAGLAVSLAAAALLNERLSPVTAVAEGIAEITPGKLVEVAISAVGTWDKPLLVGGVVLGLLGLSAAAGALAGRSVRRGQLVFLVMGLLALAAVLGPGGGATSAVVPVLAGTITWLAVLPVLVPPSASRGETVGEPARHRETAGGTEELGGTAGRAAPASDASRRTFLVRAGVVAGLSLAVGAGAQLLGRRRRLVEAARSRLRLPASRGALPDGVELGPDGPAGLTPWRTPNNDFYRIDTAFAVPAVDVDTWRLRIHGMVEEEVTVSFADLLDAEQTEAWVTLCCVSNEVGGDLIGNAWWSGVRVAELLARARPLPGADAVLQTSEDGWTCGTPLSALTDDRHALLAVAMNGEPLPLEHGFPVRMVVPGLYGFVSATKWVVDLEVTRLDEIEAYWTTNGWAEQAPIRTQSRIDVPRANQRADSGTLAVGGVAWSQHLGIERVEVRLDGGAWTEVGLAAAGPDDDTWVQWAGSVEVDPGVHTLAVRATDRSGYTQTGVRRDVVPDGATGWHTVELTVE

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Crispr_ID: NZ_CP049867_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_3

110283-110367

Orphan

Consensus_repeat	Method
CGGTTTCACTAGGTACCTAGTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_3

>merge|NZ_CP049867|3|110283-110367|CRISPRCasFinder
CGGTTTCACTAGGTACCTAGTGATTCTGGCGCTTCCCGAGCGAAGTTTCGTCAGGGAAGCGCCGGTTTCACTAGGTACCCAGTGA

>NZ_CP049867|3|3|110283-110367|CRISPRCasFinder
CGGTTTCACTAGGTACCTAGTGA	TTCTGGCGCTTCCCGAGCGAAGTTTCGTCAGGGAAGCGC
CGGTTTCACTAGGTACCCAGTGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166083697.1\|108167_108767_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166089458.1\|101754_103086_+\|D-inositol-3-phosphate-glycosyltransferase	unknown	unknown	gnl\|CDD\|132490
NZ_CP049867.1\|WP_166083701.1\|110382_110883_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|178851
NZ_CP049867.1\|WP_166083698.1\|108816_109533_-\|UbiA-family-prenyltransferase	unknown	unknown	gnl\|CDD\|260119
NZ_CP049867.1\|WP_166089465.1\|122076_122844_-\|cobalamin-binding-protein	unknown	unknown	gnl\|CDD\|238564
NZ_CP049867.1\|WP_166083703.1\|112634_113975_-\|peptidase-C39-family-protein	unknown	unknown	gnl\|CDD\|239109
NZ_CP049867.1\|WP_166083706.1\|115540_116494_+\|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB	unknown	unknown	gnl\|CDD\|223640
NZ_CP049867.1\|WP_166083699.1\|109713_110199_+\|CarD-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224248
NZ_CP049867.1\|WP_166083695.1\|106475_107297_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP049867.1\|WP_166083708.1\|117817_119209_-\|mercuric-reductase	unknown	unknown	gnl\|CDD\|235787
NZ_CP049867.1\|WP_166083710.1\|120818_121964_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173849
NZ_CP049867.1\|WP_166083696.1\|107410_108163_-\|phosphoglyceromutase	unknown	unknown	gnl\|CDD\|184519
NZ_CP049867.1\|WP_166083709.1\|119283_120777_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
NZ_CP049867.1\|WP_166083702.1\|110966_112631_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239028
NZ_CP049867.1\|WP_166083694.1\|105753_106410_+\|phosphate-signaling-complex-protein-PhoU	unknown	unknown	gnl\|CDD\|273990
NZ_CP049867.1\|WP_166089460.1\|103120_103627_+\|YbjN-domain-containing-protein	unknown	unknown	gnl\|CDD\|371210
NZ_CP049867.1\|WP_166089463.1\|104412_105597_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|274368
NZ_CP049867.1\|WP_166083707.1\|116677_117616_-\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|379128
NZ_CP049867.1\|WP_166083704.1\|114069_115476_+\|cysteine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234705
NZ_CP049867.1\|WP_166083693.1\|103738_104416_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166089458.1\|101754_103086_+\|D-inositol-3-phosphate-glycosyltransferase	gnl\|CDD\|132490	TIGR03449, mycothiol_MshA, D-inositol-3-phosphate glycosyltransferase. Members of this protein family, found exclusively in the Actinobacteria, are MshA, the glycosyltransferase of mycothiol biosynthesis. Mycothiol replaces glutathione in these species.	0
NZ_CP049867.1\|WP_166083709.1\|119283_120777_+\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.0726e-125
NZ_CP049867.1\|WP_166083701.1\|110382_110883_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|178851	PRK00084, ispF, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed.	1.87077e-74
NZ_CP049867.1\|WP_166083698.1\|108816_109533_-\|UbiA-family-prenyltransferase	gnl\|CDD\|260119	cd13956, PT_UbiA, UbiA family of prenyltransferases (PTases). Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.	2.06118e-10
NZ_CP049867.1\|WP_166083703.1\|112634_113975_-\|peptidase-C39-family-protein	gnl\|CDD\|239109	cd02549, Peptidase_C39A, A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature or have different domain architectures.	7.53051e-25
NZ_CP049867.1\|WP_166083706.1\|115540_116494_+\|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	7.46332e-77
NZ_CP049867.1\|WP_166083699.1\|109713_110199_+\|CarD-family-transcriptional-regulator	gnl\|CDD\|224248	COG1329, COG1329, Transcriptional regulators, similar to M. xanthus CarD [Transcription].	1.64559e-62
NZ_CP049867.1\|WP_166083695.1\|106475_107297_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	2.74967e-08
NZ_CP049867.1\|WP_166083708.1\|117817_119209_-\|mercuric-reductase	gnl\|CDD\|235787	PRK06370, PRK06370, FAD-containing oxidoreductase.	0
NZ_CP049867.1\|WP_166083710.1\|120818_121964_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	3.0946e-143
NZ_CP049867.1\|WP_166083696.1\|107410_108163_-\|phosphoglyceromutase	gnl\|CDD\|184519	PRK14120, gpmA, phosphoglyceromutase; Provisional.	1.35954e-170
NZ_CP049867.1\|WP_166089465.1\|122076_122844_-\|cobalamin-binding-protein	gnl\|CDD\|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	1.94054e-48
NZ_CP049867.1\|WP_166083694.1\|105753_106410_+\|phosphate-signaling-complex-protein-PhoU	gnl\|CDD\|273990	TIGR02135, Uncharacterized_protein, phosphate transport system regulatory protein PhoU. This model describes PhoU, a regulatory protein of unknown mechanism for high-affinity phosphate ABC transporter systems. The protein consists of two copies of the domain described by pfam01895. Deletion of PhoU activates constitutive expression of the phosphate ABC transporter and allows phosphate transport, but causes a growth defect and so likely has some second function. [Regulatory functions, Other, Transport and binding proteins, Anions].	5.96152e-54
NZ_CP049867.1\|WP_166083702.1\|110966_112631_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239028	cd02110, SO_family_Moco_dimer, Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). .	3.62423e-66
NZ_CP049867.1\|WP_166089460.1\|103120_103627_+\|YbjN-domain-containing-protein	gnl\|CDD\|371210	pfam10722, YbjN, Putative bacterial sensory transduction regulator. YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabilizer for some other unstable proteins. This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.	3.96936e-18
NZ_CP049867.1\|WP_166089463.1\|104412_105597_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	4.33078e-73
NZ_CP049867.1\|WP_166083707.1\|116677_117616_-\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl\|CDD\|379128	pfam13338, AbiEi_4, Transcriptional regulator, AbiEi antitoxin. AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	0.00209802
NZ_CP049867.1\|WP_166083704.1\|114069_115476_+\|cysteine--tRNA-ligase	gnl\|CDD\|234705	PRK00260, cysS, cysteinyl-tRNA synthetase; Validated.	0
NZ_CP049867.1\|WP_166083693.1\|103738_104416_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.48947e-93

>NZ_CP049867.1|WP_166083699.1|109713_110199_+|CarD-family-transcriptional-regulator
MTFTVGETVVYPNHGAAVIEDIETRTIKGEDREYLVLRIVAQQDLVVRVPACNLDLVGVRDVVDKEGLDKVFDVLRMAHAEEPTNWSRRYKANLEKLHSGDVMKVAEVVRDLWRRERDRGLSAGEKRMLAKARQILVSELALAESTNEDKAEALLDEVLAS
>NZ_CP049867.1|WP_166083698.1|108816_109533_-|UbiA-family-prenyltransferase
MSKRKRPGFALSLLRASHPGESLVIAVGVTLGAVLIGRPLREVALVFATVLLGRLTAGWLNDAADRRRDAAAGRLDKPVAQGWVDGGTVTFTVACATCVLVPLSISNGTVAGVAHLLSVLAAWAYCTRIKTTRLSFLPWAISFALLPAFLSYGGWGGGVHGGPPTVLMTVLAGLLGVGVHVILALQDLVGDNRIGLRTFPLMIALKIGAGKLLVLSGVWTVAVLGGIVAAGLGPGLTQ
>NZ_CP049867.1|WP_166083697.1|108167_108767_-|hypothetical-protein
MTASRLRPVAAPRSRARRLLALTLATPLLAACSVNFGAQTDQVYTPAQGVNDRSTDIDVLNALVVAESDGSGRLIAGLASQADEDVELQGVQGVEEDAEVQFGSDGGDTVVPAGGFLQLADEGSAVISATGEGVEIGDYVRLTMSFSNGDEVDLNVPVVVPGEDFADVTLPSSGSSESSSEEPSAEPSESPSESPSSEG
>NZ_CP049867.1|WP_166083696.1|107410_108163_-|phosphoglyceromutase
MSAPYTLVLLRHGESDWNAKNLFTGWVDVALTDKGREEAARAGRLLTEAGVLPDVLHTSLLRRAITTAQLALEEAERHWVPVRRSWRLNERHYGALQGKDKKATLEEYGEEQFMLWRRSYDTPPPALDDDNEWSQVGDPRYDLLPGELMPRTECLADVIDRMLPYWYDAIVPDLRDGRTVCVAAHGNSLRGLVKHLDGISEEEVVGLNIPTGIPLVYRLDEDLHPTERGGQYLDPDAAADAIKAVASQGR
>NZ_CP049867.1|WP_166083695.1|106475_107297_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MDSATPAEPGLDFVEEFASAAEWFATHLGRTSARAPVPACPDWSVLDLVAHLGNVHAWAATVVETGAKAEQLDDRPSSARSRRVSEWYLAKAEDLYEVLRAADPSAPCWTFVDDAGTAAFWARRQAHETVVHGFDLAVAGDHEPRVPPRLAVDGVSEVLEVFLGRMHRRGHPAVLHRALELRATDAEESWVLEPAPVGIPAQGASPEQREERPTTRAVPVVTRGSRDDLDRIEAPAATLLTLLWRRTRPDAADVRLVGNEDRLRAFLQSRLTP
>NZ_CP049867.1|WP_166083694.1|105753_106410_+|phosphate-signaling-complex-protein-PhoU
MRTAYHDQLDAIVDDLVRLTGMVQDATSQATTALLSADAGVAEQVLRGDAAIDALRNDIEGRAFELLALQQPVAGDLRMLIATVRMVADLERMGDLAVHVAKVAQLRVPEVAVPPDLIPTVERMAAVAVHMIGSVAEVIKNRDVDAARSVESDDEEMDELRRRSFRLMLGESWAYGVEPAIDNALLGRYYERIADHAVSLARRVVYLVTGEVPTALDG
>NZ_CP049867.1|WP_166089463.1|104412_105597_-|two-component-sensor-histidine-kinase
MLLLLGIFLGALPVLAWHASERQLRGRKPPEEPAADVVPPGVATVLNVLRSSALVVDAEDRVVQASAPAYSLGLVRDGELRNDELAALVAKVRRDGEIRQVDLDIHRTGQQPVHVNARVAALSSRLVLVLTEDRTRERRVDAIRRDFVANVSHELKTPVGALTLLAEAVREAADDPEAVQRFAARMQTEAVRLNRLVQQIIELSRLQGDEALERPAMVPVDRVVERSIDFNEIEATAKGIEVVYDGRRGLSALGNPDQVSLAVSNLVANAIAYSPEGSRVVVSALQQELMVDITVTDEGIGIPRAELDRIFERFYRVDPARHRSTGGTGLGLSIVKHVAATHGGEVKVWSEPGKGSSFTLRLPRHTATPAPAPGPAPDRASAVPTPVPSVKESS
>NZ_CP049867.1|WP_166083693.1|103738_104416_-|response-regulator-transcription-factor
MTRVLVVEDEESYSDALAYMLRKEGFEVSLAATGLQALEEFDRSGPDIVLLDLMLPELSGTEVCRRIRAVSNVPVIMVSAKDDEVDKVVGLELGADDYVTKPYAPRELVARIRAVLRRGNEVEAAPAALEAGPVRMDVERHLVSVNGADTPLPLKEFELLEMLLRNPGRVLTRGQLIDRVWGSDYVGDTKTLDVHVKRLRAKIEPDPANPVHLVTVRGLGYKFDA
>NZ_CP049867.1|WP_166089460.1|103120_103627_+|YbjN-domain-containing-protein
MREQAVATVRAVLADNELEHTEVSPGVFSVTLPGEKKLQTPCRLDVGPHALGVHAFVARHPDENHARVYRWMLERNLKLYGVAFAVDHHGDIYLDGRLPLSSVTPEELDRLLGAVLSYADESFNTLLELGFGSSIRKEWEWRISRGESTRNLDAFRGWLEATGTPTEQ
>NZ_CP049867.1|WP_166089458.1|101754_103086_+|D-inositol-3-phosphate-glycosyltransferase
MQRPPVRPESSAEPLDLSVARSPRRVAMISLHTSPLDQPGVGDAGGMNVYVLELSRRLAERNLEVEVYTRATSSTMDPVVEAAPGVRVHHVAAGPYEGLGKEELPAQLCVFARHLLRAEAGHEQGWFDLIHSHYWLSGQVGALVRDRWSVPLVHTMHTMAKVKNALLAEGDTPEPTARLLGEDQVVEAADMLIANTGLEAQQLIDLYAADPARVEVVHPGVDLGMFVPRPQRDARARLGLPADAIVPLFVGRLQPLKAPDVLLRAVALLVRDDPALRSRLVVPVVGGPSGSGLEHPTALADLAGELGIGDLVRFVPPVGRAELVDWYAAATVVCVPSYNESFGLVAIEASAVGTPVVAAAVGGLTTAVRDGETGLLVDGHDPADYAAALRRLVSDTAYRERLASAAALHARDFAWERTAERTLEVYRKAAHAMRHDLQDVVRA
>NZ_CP049867.1|WP_166083701.1|110382_110883_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MDDPAVSAPLPLPRTGIGVDVHAYAEGVPMWLAGLHFEDETHGLDGHSDADVAAHAACDALFSACGLGDLGSNYGTSDPAWAGASGVALLAETARRVREAGFTIGNVAVQVIGNRPRLGPRRAEAEATLSEAAGAPVTVSATTTDGLGLTGRGEGVAAIATALVAR
>NZ_CP049867.1|WP_166083702.1|110966_112631_+|molybdopterin-dependent-oxidoreductase
MGHHGAVSPSPTPPPADARASRRTSIPGQSLLAGVLTGVAGLAVSLAAAALLNERLSPVTAVAEGIAEITPGKLVEVAISAVGTWDKPLLVGGVVLGLLGLSAAAGALAGRSVRRGQLVFLVMGLLALAAVLGPGGGATSAVVPVLAGTITWLAVLPVLVPPSASRGETVGEPARHRETAGGTEELGGTAGRAAPASDASRRTFLVRAGVVAGLSLAVGAGAQLLGRRRRLVEAARSRLRLPASRGALPDGVELGPDGPAGLTPWRTPNNDFYRIDTAFAVPAVDVDTWRLRIHGMVEEEVTVSFADLLDAEQTEAWVTLCCVSNEVGGDLIGNAWWSGVRVAELLARARPLPGADAVLQTSEDGWTCGTPLSALTDDRHALLAVAMNGEPLPLEHGFPVRMVVPGLYGFVSATKWVVDLEVTRLDEIEAYWTTNGWAEQAPIRTQSRIDVPRANQRADSGTLAVGGVAWSQHLGIERVEVRLDGGAWTEVGLAAAGPDDDTWVQWAGSVEVDPGVHTLAVRATDRSGYTQTGVRRDVVPDGATGWHTVELTVE
>NZ_CP049867.1|WP_166083703.1|112634_113975_-|peptidase-C39-family-protein
MRPLRHLILPLSLAAVASALPGVASLSGLPVLATATADPPHLASLERPLPRDVAFRQWTTGPTTGLTDATDDLGDRGTFTRTEVRGGALKIGTNAAGDRALTGRWTSPWVRPGFSLTELVPSWEAATPGASSIEVEVRARSTDGVSSWDTISVWAKGDEHVRRSSGASQSDDLGRVLYDTWLAPGASAWQVRVALKRPGVDAVSPRVETVGAMVSRLPSVQRVATSLAGSHRGEALGAVLPVPRYSQMVHKGSYRQYGGGGEAWCSPTATAMVLAYYDALPPESSYSWVRAGHPDPEVAQVARATYDTSYGGTGTWPFNTAYAASRTGSAFVTRLRNLREVERFVNVGIPLVASIRFGAGELRGAPISSSNGHLLVIAGFTRAGDVVVNDPAADSRAGVRRVYDRTQFETAWLRRDSSGTGGSGGIVYVVHDEEHPLPDNMVQSNW
>NZ_CP049867.1|WP_166083704.1|114069_115476_+|cysteine--tRNA-ligase
MTIRLYDSVTREVRDFVPQQEGRAGVYVCGLTVQSEPHVGHVRSGVNFDVLRRWLTHRGLEVTFIRNVTDIDDKILVKSAEQGRPWFNLAYDMTRALTSAYDALNVLPPTYEPLATGHVPEMLALIERLIERGHAYPAADGSGDVYFDVMSWPAYGELSGQRVTEMEAAADADPRGKRDPRDFALWKGRKDSEPETASWPSPWGPGRPGWHIECSAMARKYLGPSFDIHGGGDDLRFPHHENEQAQSRAAGDGFATTWMHNAWITTAGEKMSKSLGNSLTIPAVLQRTRAIDLRFYLVAAHYRSHVEFSFEALDEAAAGFGRVENFLERAATVLGEVPLGTPCADFVTAMDDDLGTPAAVAAVHEVTREGNRLLAGGASDALRGAAGSVRAMLGVLGVNPFDPHWASGGSDDARLREAVDVLVAGLLEQRAEARAAKDFATADTLRDRIKAAGIEVEDGPSGSTWSLA
>NZ_CP049867.1|WP_166083706.1|115540_116494_+|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB
MPGNSSRKGAIRKTSKGNPTAGSGGRVRRGLEGRGPTPKAAERENHKAYKAKKRSERDAPKTAPRRSKGGDTEWIAGRNSVVEALRAEVPVTGVYVAEGAERDGRLREAFKLVAERGIPLLEVTKRELDRLTDGAVHQGLTAKVPAYEYAHPDDLLRLAKESGAPPLIVALDSVTDPRNLGAVVRSAAGFGAHGVVVPERRAAGMTASAWKTSAGAAARVPVAQCVNLTRQLKAYQDAGCMVVGLDADGEVSLPDLDLADGPLVLVVGAEGGGLSRLVAETCDQLVSIPMAHQLESLNAGVAAGVALYGIAQRRAGA
>NZ_CP049867.1|WP_166083707.1|116677_117616_-|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MDLLSPVLAAQDGAVSRTQLLECGLQPHDVRRMVRRRELSPVHPGVYVTHTGPLSDRQRLWAASLAVSGGVLAGRAAQCLGGVAVARGALDVVEVVVPFTASGRQGLAGVEVRRRRGWDGLVVVGSPPRMRVEDATVDLADRAVDVLGVVDELTRAVQSRRTTAERLLVTARNRPRLRRRTFLEDVLADVVTGACSVLEHGYLTRVERPHGLPVGRRQVRVVGPGGRSAFEDVEYDGGLVMELDGRLGHDSARGRDADFDRDLEAAADRRRTSRISYGQVFGRACWTAERVGRLLRTVCGWDGEMQACRFCA
>NZ_CP049867.1|WP_166083708.1|117817_119209_-|mercuric-reductase
MSTDAASDAHYDTIVIGAGQAGPGLAATLAGEGERVALVEQDRFGGTCLNSGCRPTKALRGTARAAHVARSSAGLGVHVDGVRVDLAEAIGRKDSLIDGWRASSVDWVEGAEGIDYLHGRARLVGTSDGSHHVDVDGRSLTARRVVLNTGARSVPPPIDGLDDVPWMDHHGILDVTELPSHLVVLGGSYIGLELGQVFSRFGARVTVVERGERVISREDAEVSEAVAAFLRDEGMTVLTGVEVDRVSRGGAGVLVALADGTELDASHVLVAAGRVPNSDDLGLDTVGVSTDDRGYVETDEVFATNVSGVYALGDVNGRGAFTHTSYQDGEILGDHLTGGSRTVGGRVMTYALFTDPPLGRVGASEDQLKRAGTPYRVSSTPMSGVTRAVLDGETDGLVKLLVGEDDQVLGAACLGIGGDELAQLFSLMMHAKVPVTEITTWLPIHPTVTEFLPTFVASLASPG
>NZ_CP049867.1|WP_166083709.1|119283_120777_+|amino-acid-permease
MSLWRTKSIEQSIRDTDDPDHKLRKDLGALDLMVFGVGVIIGAGIFVLTGTVAASNSGPALALSFVIAAVACGLAGLCYAEFASTVPVAGSAYTFSYATLGELVAWIIGWDLVLEFTIGSAALASSFSGYLQNVLDGVGVTLPTQLSSASEGFVDLPAVLCALLVMALLIRGTKLSSRFNQVVVAIKLLVVLIVIVVGVTLIDTSNWVPFIPESQPVPESGGGFRDLPLITSLFGIEPAIFGVAGVVAGAAVVFFAFIGFDIVATTAEEAKNPQRDVPIGILGSLAVVTVLYAAVSLIVTGVQSYEDIDPNDAAPLATAFDAAGVEWMGDVIAVGACIGLIVVAMILMLGQSRVAFAMARDGLLPAKLAQVHPRFGTPHRITLITGTVVAVIAGFVDLATLANLVNIGTLFAFILVSIAVVVLRRTRPDLPRAFRTPAAPLVAGLAVLLCLYLMLNLTGETWERFLIWMALGVVVYFAYGRRHSRLGRETLERRTSQ
>NZ_CP049867.1|WP_166083710.1|120818_121964_+|acyl-CoA-dehydrogenase
MKREIYDEDHEAFRGSVREFLDRSVKPHLEEHLENKALPRDFWIEAGTQGFLGLEVPEEFGGSEAGDYRFNAVLMEELSHVNAALSSCVGIHADIVAPYLVELTSDEQKKRWLPGVASGELLTAIGMTEPSGGSDLAALKTSAVRDGDDWVLNGSKTFITNGYSADLVVVAARTSPEKKARGITLFGVETSKDGYSKGRKLDKVGQTESDTAEMFFEDLRCTDDDIVGELDNGFIHMMQKLPQERLGCAISNLAHARQILVETLEYSKERKAFGQGVGSFQHNKFLIAEMFTQVDVTQAYVDQCVVAHDRKELTAIDAAKAKWWTSQVQNEILDHCVQLHGGYGYMNEYRVARAWRDARVSKIWAGSNEIMKELIGRDLGL
>NZ_CP049867.1|WP_166089465.1|122076_122844_-|cobalamin-binding-protein
MPPRPSRDDLGALVDVPAPARRVVSLVPSLTEAIARTRPDALVGATDWCTHPADLDVARVRGTKNPDLAAIRALEPDLVVCNREENRELDVRRLRDAGVPVWVSVIETLPQALTAMERIFDEALGWGVPAWLEEVERRWDRPVPPVAARVAMPIWRDPWMVVGRHTFTDDLLRRLGWQNVYADGGPGADRYPTVTVADLEAAGPDVVLLPDEPYVFTAEDGPEAFDVPTRLVSGRLLTWYGPSLLAAADDPTLRP

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Crispr_ID: NZ_CP049867_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_4

178570-178654

Orphan

Consensus_repeat	Method
TCACTGGGTACCTAGTGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_4

>merge|NZ_CP049867|4|178570-178654|CRISPRCasFinder
TCACTGGGTACCTAGTGAAACCGGCGCTTCCCGCACGAAACTTCGCTCGGGAAGCGCCAACATCACTAGGTACCTAGTGAAACCG

>NZ_CP049867|4|4|178570-178654|CRISPRCasFinder
TCACTGGGTACCTAGTGAAACCG	GCGCTTCCCGCACGAAACTTCGCTCGGGAAGCGCCAACA
TCACTAGGTACCTAGTGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166083766.1\|183725_185753_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	unknown	unknown	gnl\|CDD\|273520
NZ_CP049867.1\|WP_166089481.1\|186999_187872_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NZ_CP049867.1\|WP_166089479.1\|172423_173473_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP049867.1\|WP_166083759.1\|173479_174535_+\|inositol-phosphorylceramide-synthase	unknown	unknown	gnl\|CDD\|379588
NZ_CP049867.1\|WP_166083761.1\|176608_178555_+\|acyl-CoA-oxidase	unknown	unknown	gnl\|CDD\|173839
NZ_CP049867.1\|WP_166083755.1\|166792_167500_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|378988
NZ_CP049867.1\|WP_166083767.1\|185749_186364_+\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NZ_CP049867.1\|WP_166083757.1\|169633_170734_+\|thiamine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270263
NZ_CP049867.1\|WP_166083763.1\|179263_180700_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|200042
NZ_CP049867.1\|WP_166083762.1\|178665_179157_-\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|376376
NZ_CP049867.1\|WP_166089480.1\|180866_181916_+\|zinc-dependent-metalloprotease	unknown	unknown	gnl\|CDD\|274833
NZ_CP049867.1\|WP_166083770.1\|188272_188665_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NZ_CP049867.1\|WP_166089477.1\|167708_168731_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293811
NZ_CP049867.1\|WP_166083756.1\|168795_169479_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166083765.1\|183089_183641_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP049867.1\|WP_166083769.1\|187868_188276_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379209
NZ_CP049867.1\|WP_166083760.1\|175127_176573_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_CP049867.1\|WP_166083764.1\|181947_183048_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|238950
NZ_CP049867.1\|WP_166083758.1\|170730_172407_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NZ_CP049867.1\|WP_166083754.1\|165612_166698_+\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|226326

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166083766.1\|183725_185753_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP049867.1\|WP_166089481.1\|186999_187872_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	1.9663e-110
NZ_CP049867.1\|WP_166089479.1\|172423_173473_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	2.17413e-107
NZ_CP049867.1\|WP_166083759.1\|173479_174535_+\|inositol-phosphorylceramide-synthase	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	6.3488e-29
NZ_CP049867.1\|WP_166083761.1\|176608_178555_+\|acyl-CoA-oxidase	gnl\|CDD\|173839	cd01150, AXO, Peroxisomal acyl-CoA oxidase. Peroxisomal acyl-CoA oxidases (AXO) catalyze the first set in the peroxisomal fatty acid beta-oxidation, the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. In a second oxidative half-reaction, the reduced FAD is reoxidized by molecular oxygen. AXO is generally a homodimer, but it has been reported to form a different type of oligomer in yeast. There are several subtypes of AXO's, based on substrate specificity. Palmitoyl-CoA oxidase acts on straight-chain fatty acids and prostanoids; whereas, the closely related Trihydroxycoprostanoly-CoA oxidase has the greatest activity for 2-methyl branched side chains of bile precursors. Pristanoyl-CoA oxidase, acts on 2-methyl branched fatty acids. AXO has an additional domain, C-terminal to the region with similarity to acyl-CoA dehydrogenases, which is included in this alignment.	0
NZ_CP049867.1\|WP_166083755.1\|166792_167500_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|378988	pfam12900, Pyridox_ox_2, Pyridoxamine 5'-phosphate oxidase. Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyzes the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.	1.83284e-40
NZ_CP049867.1\|WP_166083767.1\|185749_186364_+\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	3.13583e-109
NZ_CP049867.1\|WP_166083757.1\|169633_170734_+\|thiamine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270263	cd13545, PBP2_TbpA, Substrate binding domain of thiamin transporter, a member of the type 2 periplasmic binding fold superfamily. Thiamin-binding protein TbpA is the periplasmic component of ABC-type transporter in E. coli, while the transmembrane permease and ATPase are ThiP and ThiQ, respectively. Thiamin (vitamin B1) is an essential confactor in all living systems that most prokaryotes, plants, and fungi can synthesized thiamin. However, in vertebrates, thiamine cannot be synthesized and must therefore be obtained through dietary absorption. In addition to thiamin biosynthesis, most organisms can import thiamin using specific transporters. After binding thiamine with high affinity, TbpA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The thiamine-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.97145e-93
NZ_CP049867.1\|WP_166083763.1\|179263_180700_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|200042	TIGR00666, D-alanyl-D-alanine_carboxypeptidase_DacB, D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family. In E. coli, this protein is known as penicillin binding protein 4 (dacB). A signal sequence is cleaved from a precursor form. The protein is described as periplasmic in E. coli (Gram-negative) and extracellular in Actinomadura R39 (Gram-positive). Unlike some other proteins with similar activity, it does not form transpeptidation. It is not essential for viability. This family is related to class A beta-lactamases. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	1.9393e-46
NZ_CP049867.1\|WP_166083762.1\|178665_179157_-\|inorganic-diphosphatase	gnl\|CDD\|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	1.97398e-84
NZ_CP049867.1\|WP_166089480.1\|180866_181916_+\|zinc-dependent-metalloprotease	gnl\|CDD\|274833	TIGR03883, DUF2342_F420, uncharacterized protein, coenzyme F420 biosynthesis associated. A phylogenetic tree of the DUF2342 family (TIGR03624) consists of two major branches. One of these branches, modeled here, is observed almost entirely to be found in coenzyme F420 biosynthesizing species of the Actinobacterial, Chloroflexi and Archaeal lineages. The few organisms having genes within this family and lacking F420 biosynthesis may either have an undiscovered F420 transporter, or may represent F420-to-FMN revertants. This family includes a Chloroflexus Aurantiacus protein whose crystal structure has been determined (PDB:3CMN_A). This has been annotated as a putative hydrolase, but the support for that assertion is untraceable. There is no cofactor present in the structure.	4.36487e-148
NZ_CP049867.1\|WP_166083770.1\|188272_188665_+\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	1.10971e-42
NZ_CP049867.1\|WP_166089477.1\|167708_168731_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293811	cd07725, TTHA1429-like_MBL-fold, uncharacterized Thermus thermophilus TTHA1429 and related proteins; MBL-fold metallo hydrolase domain. Includes the MBL-fold metallo hydrolase domain of uncharacterized Thermus thermophilus TTHA1429 and related proteins. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.37894e-22
NZ_CP049867.1\|WP_166083765.1\|183089_183641_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	2.49969e-86
NZ_CP049867.1\|WP_166083769.1\|187868_188276_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379209	pfam13474, SnoaL_3, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	7.43934e-25
NZ_CP049867.1\|WP_166083760.1\|175127_176573_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.43471e-29
NZ_CP049867.1\|WP_166083764.1\|181947_183048_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	1.22978e-61
NZ_CP049867.1\|WP_166083758.1\|170730_172407_+\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	4.33944e-71
NZ_CP049867.1\|WP_166083754.1\|165612_166698_+\|diacylglycerol-kinase	gnl\|CDD\|226326	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown].	5.43896e-84

>NZ_CP049867.1|WP_166083761.1|176608_178555_+|acyl-CoA-oxidase
MGSMPTESETHVDVAALTTLLDGRYKQVRDLVRENLVLHRQLLDEAETLDTTAYRERVKDVVVELAKTGQTGYGFPKEYGGGGDIGASVAAFETTAMGDLSVLVKLGVQFGLWGGAVLQLGTERHHREYLEATARGEVMGCFAMTETGHGSNVQAIGTTAVFDPDTDEFVITTPDDASRKDYIGNAAMHAHVGAVFAQLEVAGEKHGVHAFVVPLRDEKGRVLDGVRIEDCGPKVGLNGVDNGRIWFDHVRVPREAMLNKYADVTEDGAYVSPIDNPDRRFFTMLGTLVQGRVCVGGGAVNAAKVAQVIAVRYALRRRQFGPPDGESETLLLDYGQHQRRLLPALARTYALHFAQERVAADLHRVFSDPDNASERLRRALESRAAATKALGTWHASRTIQECREACGGAGYLSINRFDALRADTDVFTTFEGDNTVLMQLVAKGRLTDLRDSFGKLDQIGTAAYVAGIAVETVVEKTSMRQIIESLRDAVPGRDREGDPDAGLLDPDYHLSMLRWREDHLTSGVARRLKAGIDRGGDPAEVFSRAQDHVIAAAWAHSERLVLEAFLTKVRNTPDGSNRRVLGMLADLFALSVIEADRAWFMEHGRLSSARSKAVIAMVGELCRQVRPHAADLVDAFGVPDELLRTDLF
>NZ_CP049867.1|WP_166083760.1|175127_176573_+|C40-family-peptidase
MPATRTSSARERTLRDRRGPRAVVTGLCLTLTVALAGSLVTLGSPAGTAYGAPRDLPPGTPSRADVEAAERRAGDAAGAVAATEAELAAADAELESAAVAAEQASEAANGARWQLEQATTALADARRDARRAEAAVAGQRDDIAALAVAGYEGAGDLSSLDAAFGAQGPEGVMSTLLTYEGASTSLEAEYQRFAATSALATTFRQEADDEQQRRADAADRAEAAQAEAVAAAASAQQVAASIADRKSALIAELARLQGVSVRLVEARRAGIEEARRQAAAAAQEAAARAAAREERAAARAAIRDTSAQDGDATGSGSSEAPVEAPADDADGSAATAPAPAPAPAPAPAPAPAPAVTPPPSASGAQRAIAFARAQVGDPYVWGAAGPSSWDCSGLTMAAWAAAGRSLPHYSVAQYTESTPISASQLRPGDLVFWGSSSSPGSIHHVALYVGDGLIAHAPRTGRDVTVESMYYWVPPNFFARV
>NZ_CP049867.1|WP_166083759.1|173479_174535_+|inositol-phosphorylceramide-synthase
MKRPAYGLLVGVAILTGLVAVVASWSLDERLRDPDGFLGPAWVRLPAMVVGAFLADVVPRAFWRAGRQPSTVMRHARQIVREHWTRERVSLVVIGLTSFYVTYVSYRNLKNYLPRIYDTMQDPLLHQLDRWLFFGNEPAVVLHAIFGETWAAHFFAFIYLLYLPIAPLSLVIWLVWSRNISYGYWYATANCLTWTLGTISYYLIPTMGPTFWYPWLYEGLQVTGVTELQDSLWRGRQDVRFPLNPFSDSIQSVAGFASLHTALTLVIALVAHYTVRHRLIRWSAWVFFGLTVISTLYFGWHYIADDVGGVIIAVLAVWLGGIATGQKFERWGRSVRPTTSTSAVPVDEDAV
>NZ_CP049867.1|WP_166089479.1|172423_173473_+|ABC-transporter-ATP-binding-protein
MEVRDLDVTLAGTPVLRDVSLDLPAGEVLAVLGPSGCGKSTLLRAVAGLERLDRGAVRVGGQDVTRVPTYRRGFALMFQDGQLFGHLTVAQNVAYPLRLRRVGRRERAARAAELLELVGVPGFGDRDPATLSGGERQRVALARALAVEPRLLLLDEPLSALDRDLRERLAVDLRRILTTAGTTALLVTHDHDEAFAVADRMALLRAGRLVQDGTLEEVWRHPVDAEAARFLGYARVLTADQARPLRAAYADRSPDGRALALRRSALQVDAAGSVPATVVTSRSTPEQTRLVVRLEDGLELDAVAPAGRACAAGELVRLTLDVTRVAPLPTHATPTEAGPDVPTPGTSVE
>NZ_CP049867.1|WP_166083758.1|170730_172407_+|iron-ABC-transporter-permease
MTSRQARPTGVPSAGLVVGLLAALVPLAVIVVFFVVPLVGMVQRGFVVDGRLDVGGVLADLARPRVAGVLWFTLWSSAVATAVTLLLGVPTAYALHRLDLPGSAFLRGLVTVPFVLPTVVVGVAFRTLLSSGGPLGGLGGDGTPAAIVAALVFFNLSVVVRMVGPWWASLDPQREQAAAALGASPAQVFRTVTLPALRPVLLSAGSVVFLFCATAFGVVLTLGGTRYSTVETEIYLLTTQFLDLRAAAALSVLQVLVVVALLLLAGRAQPRGAGVVDRAAPAPGRRPRGWVDLTALATTAVTVALVALPLLAVVARSLRVDDAWSLARYRSLSESAPGSPLRTSVLDAAATSLRTATDATLLAVGLGVVVSVLVTRRIAHPGLRRAVRAFDGLFMLPLGVSAVTVGFGLLVALDTPPLDFRGSPWLVPVAQALVALPLVVRALVPTLRGVDERQREAAATLGAGPLRILRDVDLPTAWRSLLAAAGFAFAVSLGEFGATSFLSRPDSPTLSVLIYQLIGRPGAESFGTALAAAVLLGSLTAGVLLAVERLRVGRLGVY
>NZ_CP049867.1|WP_166083757.1|169633_170734_+|thiamine-ABC-transporter-substrate-binding-protein
MKHARPRWRAAAAVTAAALALTACSITGGSEQETTTGTAADGSTVADRDVTLLVHDSWYLPRKVLRAFEEETGYRVEVQTNGDAGSLTNKLVLTADNPLGDAVFGIDNTFATRAADEGVLAPYTPADLPASAADYALDGEAGEQLTPVDWGDVCVNVDDAWFAERDQAPPRTLADLADPAYRDLFVTPAASTSSPGFAFLLATVGEYGEDGWQDYWTRLMDNGARVAKDWTEAYTVDFTAGGGDGDRPIVLSYSSSPPFTIPKGEERPTTSALLETCFRQVEYAGVLAGADNPEGAQSLLDFLVDRTFQKALPDSMYVYPVDAETPLPPLWEEWAEPATDPIEVDPAEVTAQRDEWIRTWSDLTAG
>NZ_CP049867.1|WP_166083756.1|168795_169479_+|hypothetical-protein
MDGDVTGTTSSGAAELDRQVDRLVEVGHPALAGLTEDAFRERLAPLHAVVPDDPADPPDPADPADPPPDQAMGFLLVVTAALVPTVAAVETWRVRGKAGWTDMADELAGFRPVPEVAVGLPDATAYLLLDVRTGRDTLGVRPSEAQPGILAAGRTPLTIDEGVALVTQRPDVFTTHHAFQALGSRADNARVPSFWVSKGAPRLGWCWWNNPHSWLGAASAAGRRGPA
>NZ_CP049867.1|WP_166089477.1|167708_168731_+|MBL-fold-metallo-hydrolase
MADRTTWTEPTAEVVAPGVRRVPLPLPMDGLRAVNVYVLETADGLTCIDGGWALEVSRTRFEESLATFGAGVGDISRFLVTHAHRDHYTQAAAIRSELGRATVELGIGDKATLDLFNSGTLDHDPTVPRLRLAGAADTAAAWEKMFEGNDPDLSVWQPPDRWLDGEQEIVVGDRVLTAVPTPGHTAGHFVFADLAASLLFAGDHVLPTITPSVGFELVYAEDPLRDFLGSLERVRRLPDLRLLPAHGAVTDSSHARVGELLAHHDERLELCRRAVAGGAVTAYDVARQLAWTRRERAFADLDVFNGAMAVMETMVHLDLLAGDGVLVRSATDGVATYAVA
>NZ_CP049867.1|WP_166083755.1|166792_167500_-|pyridoxamine-5'-phosphate-oxidase-family-protein
MSSPSDQSTPDPSSTPQRGLVVDDATRIRREAHRQVTDRDALDAVLDEALLAHVGVVRDGRPLVLPFACARDGDHLLLHGSTGSGLLRIAAGDEVCVEVTHLDGLVFARTTFDSSMRYRSAVVHGVAEEVPADDKARALDLLSDHLFPGRTAELRAPTAKELAATLVLRVSLESASVKVAAGPPEVDPDDHEPRSVWAGIVPLALRADQPLASPDVPHGVDVPASVRATLTRHGV
>NZ_CP049867.1|WP_166083754.1|165612_166698_+|diacylglycerol-kinase
MIRVVEWSTGTVGRHAIAGILARPELELVGVWVSSEAKHGRDVGELCGGPPLGLPATMHKHELVALRPDVVVHTAMTDADPFAAVELFRELLAAGINVVSSGPVFLQFPHGVIPDEMVAQLEEAGRSGGASLHVNGIDPGFANDVLPLTLTSLSQRVDEVRVSEIADYSTYDQPFVNGELFGFGKPVDDVPFLFSDGVLPLAWGSVVRIIAAGLELELDEPLTATVEHAEASRDYETVSGPVPAGTRCAVRFQVVGSVAGIPRVVLEHVTRTHPEQRPDWPQPPTGDGCYRVEVVGEPMMTLDLTHRGEHGDHNVSGMITTAMRLVNAVEAVVAAPPGLVTALDLPLITARGLVPRDPVTS
>NZ_CP049867.1|WP_166083762.1|178665_179157_-|inorganic-diphosphatase
MEFDVLVEIPKGQRNKYEVDHESGRIRLDRTLFTSTQYPADYGFIEDTLGLDGDPLDALVLLQEPTFPGCLIKCRAIGMFRMTDEAGGDDKVLCVPATDPRLEHLRDISHVSKFDRLEIQHFFEVYKDLEPGKSVEGAEWVGRTEAEAEVVASQKRHQDTPGH
>NZ_CP049867.1|WP_166083763.1|179263_180700_+|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MRRALIVIGLTLVLVLGLVVWRADDLGVSDLVDDLTGASDPPPASEGPAAVPPPPGLDLPRLPDAQPVARERVDRAIDPRAVRQSLGRLTRDKRLGPRVAVAVAGPDGRPAYEEGPRVVTPASLLKTAISLAALELLGPEHRFTTSVVRRGGVLTLVGGGDPLLTGAPDPGAVPRRADLTTLARQTATALRAEKRGGPARVTLRYDDSLFSGPAVSPDWENDYIPDNVVSPITALWIDVGREFPGALTRSADPSRAAALRFAEALRAAGTTVVGSPRPGAAPDVDPVASVASAPLVEVVQHVLETSDNEGAEVLLRQVGLADAGARGGSFAAGSRAVSSTLADLGVPLRAARILDGSGLARGNRMAVSSLLEVLATSLEPKRPLLAGVTSGLPVAGFTGSLASGRFEVDAVDGLGWVRAKTGTLTGVHGLAGSVTGRDGTPMLFVAVVDRVKIRNALQARARLDQIASALADCRCAAR
>NZ_CP049867.1|WP_166089480.1|180866_181916_+|zinc-dependent-metalloprotease
MIDWDLAVAAATRLAGPGPVVTRAEADDAVAELRAGAERSTPLVRDFTGLVAEAGTAPVLVVDRAGWIQANAEAFDHLISPVVAKLQERRGIEPGGLTAAVGSRVTGLEVGGLLGFLAGKVLGQFDPFTTEGLGRLLLVAPNIVHAERELDVDTADFRLWVCLHEETHRVQFTAVPWLRDHLQSEIDRLVDDVDVDPSRVAAMLGDAVKRTGEIVRGTGGPGTGSLLDVFATPAQREVIDRVTAVMSLLEGHADVVMDDVGPEVIGSVALIRERFNRRRKGASSMDRLIRRLLGLDAKMAQYRDGARFVRAVLDDVGMDGLNKVWVEPANLPSMAEISEPGAWMRRVHG
>NZ_CP049867.1|WP_166083764.1|181947_183048_+|tRNA-lysidine(34)-synthetase-TilS
MGPDPAVAAVRLAVRRALPVLTDDDGVRWIPDVRRPGAVLVACSGGADSLALLAATVFEVRKVDGVRVVGAVVDHALQEGSAEHTARVVAQMAQLGADETASIRVSVDPGPGGVEAGAREARYAALSRMAQHFGADRVLLGHTLDDQAETVLLGLTQGSGPRSLQGMRAEIKELGGPLVQRPMLGLTRAQTEAACRAEQIAWWEDPQNRDQRFLRARVRHVVMPLLEAELGPGVAAALARTGPMVRDDLAALDAIAEDELGRLDLATGVDLEHLEHLEHVVLTRVLRLAALAAGCPPRELTHGHVTALVEMVWRRRGEARDLDLPGHVRAVRRDDVLRIEGRQAPGDRGPDRGRGRPDDTGTHVAG
>NZ_CP049867.1|WP_166083765.1|183089_183641_+|hypoxanthine-phosphoribosyltransferase
MDAQHVQDDLVDVLFSEEDIQKRLGELAREVERDYAGEDLLLVGVLKGAVMVMADLARAFERHVEMDWMAVSSYGSGTKSSGVVRILKDLDTDISGRHVLIVEDIIDTGLTLSWLVSNLKSRNPASVEICTLLRKPDALQMPVEVRYVGHDIPDAFVVGYGLDFDERYRNLRCVGTLAPKVYS
>NZ_CP049867.1|WP_166083766.1|183725_185753_+|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein
MKRYLRTPWFWIPVAVLGVLIALQYFAPNGGYDEVDTSELAEHIAAGEVKEITFRDQDQEIKATLDDDTKVITHYIDGQQETLLEAVREQREAGDIESYNSENPTPSILGSLLTFMLPIIILVLVFLWLMNQAQGGGGRVMQFGKSKAKLISKDMPKTTFSDVAGCEEAIEELGEIKEFLQEPAKFQAVGAKIPKGVLLYGQPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKENAPAIVFIDEIDAVGRHRGAGMGGGHDEREQTLNQLLVEMDGFDVRGGVILIAATNRPDILDPALLRPGRFDRQIAVDAPDLSGRHQILQVHARGKPMGPHIDLMSVARRTPGFTGADLANVLNEAALLTARGNRKMIEPADLDEAIDRVIAGPQKRTRLMSEKEKLITAYHEGGHALVAAALPGTDPVHKVTILPRGRALGYTMVLPDEDKYSQTRSEMLDKLAYMLGGRAAEEMVFHDPTTGAGNDIEKATALARAMVTQYGMTERLGAIKLGENSGEPFMGRDFGHTRDYSEDVAAVVDEETKKFLTTAHQEAFDILVENRDVLDHLVTELLEKETLDKEQIRLIFEALRRRPVRPAWTGSPHREPSDIPPVRVPASAANGLKPEEPTGATIITPPGSGGDIHGTPPVGRSDGSEPGPRTP
>NZ_CP049867.1|WP_166083767.1|185749_186364_+|GTP-cyclohydrolase-I-FolE
MTLGPITSPSYDDVPDFDHERAAAAVRELLAAMGEDPDREGLRDTPARVARAYEEMSRGIRQRAEDVLTTTFDLGHDEMVLVRDIELWSMCEHHLVPFTGVAHVGYIPNDNGRITGLSKLARTVDVFSRRPQVQERLTTQVADAMMEILQAKGAIVVIEAEHLCMTMRGVKKPGAKTITSAIRGVMHNAATRSEAMSLIMHGTR
>NZ_CP049867.1|WP_166089481.1|186999_187872_+|dihydropteroate-synthase
MGILNVTPDSFSDGGLYADPAAGIARGLALHQSGADLVDVGGESTRPGARRPSQDEELARVVPVVRALAEQGVVVSVDTMRAEVARRSVEAGAAVVNDVSGGLADPAMLATVADLGVPYVLMHWRAHSVTMQQHTTYGDVVADVTDELSQRLEAASAVGLEADRIILDPGIGFSKDTDQNWQLLAGLDALRSLGRPVLVGVSRKRFLGELLAADGVLRPPRERDDASHAAAVLAAEAGAWCVRTHEVAAVADAVAVVARWQTARAASTPATPGATPGATSTPATPGGGAR
>NZ_CP049867.1|WP_166083769.1|187868_188276_+|nuclear-transport-factor-2-family-protein
MTPDQQDVAAANEAFYGAVERGDLDALTGLWCTEETAVCVHPGATPIHGTRNVLRSWALIMANTDYIQFFLTDVTVSVNGDVATVTCRENILTAADSGPQGFNGGLAEALNVFVRRPGGWRLWVHQASPVVSEAG
>NZ_CP049867.1|WP_166083770.1|188272_188665_+|dihydroneopterin-aldolase
MTTTPRTLTPPSDRLRVRGIEVFAHHGVLDHERRDGQTFLVDLDLEVDTAEAAATDDLTRTVDYGSLVTDVVAAVQSDPVDLIETVAERVAGVCLARERVRSVDVTVHKPDAPIPATFADVELTINRRRG

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Crispr_ID: NZ_CP049867_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_5

254647-254745

Orphan

Consensus_repeat	Method
CGCGAAGCGTCAGGCGTGTACGCGCGAAGCGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_5

>merge|NZ_CP049867|5|254647-254745|CRISPRCasFinder
CGCGAAGCGTCAGGCGTGTACGCGCGAAGCGTCGCTCGTGTACGCGCGAAACGTCGCTCGTGCACGCGCGAAACGTCGCTCGTGCACGCGCGAAACGTC

>NZ_CP049867|5|5|254647-254745|CRISPRCasFinder
CGCGAAGCGTCAGGCGTGTACGCGCGAAGCGTC	GCTCGTGTACGCGCGAAACGTCGCTCGTGCACG
CGCGAAACGTCGCTCGTGCACGCGCGAAACGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166083837.1\|255032_255404_+\|glyoxalase	unknown	unknown	gnl\|CDD\|319909
NZ_CP049867.1\|WP_166083829.1\|244154_245888_+\|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|223086
NZ_CP049867.1\|WP_166083839.1\|255800_256055_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166089487.1\|243096_244047_+\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612
NZ_CP049867.1\|WP_166083834.1\|251892_253617_+\|cytochrome-c-biogenesis-protein-ResB	unknown	unknown	gnl\|CDD\|377471
NZ_CP049867.1\|WP_166083830.1\|245895_246879_+\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450
NZ_CP049867.1\|WP_166083835.1\|253613_254633_+\|c-type-cytochrome-biogenesis-protein-CcsB	unknown	unknown	gnl\|CDD\|274447
NZ_CP049867.1\|WP_166083838.1\|255447_255714_-\|DUF4229-domain-containing-protein	unknown	unknown	gnl\|CDD\|379415
NZ_CP049867.1\|WP_166083836.1\|254765_255014_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166083832.1\|249771_250446_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP049867.1\|WP_166089491.1\|251185_251893_+\|cytochrome-c-biogenesis-protein-CcdA	unknown	unknown	gnl\|CDD\|280792
NZ_CP049867.1\|WP_166083840.1\|256076_256982_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	unknown	unknown	gnl\|CDD\|235695
NZ_CP049867.1\|WP_166089498.1\|262789_263437_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|316044
NZ_CP049867.1\|WP_166089493.1\|257134_258130_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236108
NZ_CP049867.1\|WP_166083841.1\|259067_260852_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	unknown	unknown	gnl\|CDD\|236020
NZ_CP049867.1\|WP_166083833.1\|250445_251144_+\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_CP049867.1\|WP_166089496.1\|258150_259071_+\|o-succinylbenzoate-synthase	unknown	unknown	gnl\|CDD\|235084
NZ_CP049867.1\|WP_166089489.1\|246955_248146_-\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|225501
NZ_CP049867.1\|WP_166083842.1\|260912_262787_+\|Na+/H+-antiporter	unknown	unknown	gnl\|CDD\|223104
NZ_CP049867.1\|WP_166083831.1\|248401_249775_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166083837.1\|255032_255404_+\|glyoxalase	gnl\|CDD\|319909	cd07245, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	9.54862e-29
NZ_CP049867.1\|WP_166083829.1\|244154_245888_+\|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase	gnl\|CDD\|223086	COG0007, CysG, Uroporphyrinogen-III methylase [Coenzyme metabolism].	2.19951e-63
NZ_CP049867.1\|WP_166089487.1\|243096_244047_+\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	1.78921e-134
NZ_CP049867.1\|WP_166083834.1\|251892_253617_+\|cytochrome-c-biogenesis-protein-ResB	gnl\|CDD\|377471	pfam05140, ResB, ResB-like family. This family includes both ResB and cytochrome c biogenesis proteins. Mutations in ResB indicate that they are essential for growth. ResB is predicted to be a transmembrane protein.	5.02108e-162
NZ_CP049867.1\|WP_166083830.1\|245895_246879_+\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NZ_CP049867.1\|WP_166083835.1\|253613_254633_+\|c-type-cytochrome-biogenesis-protein-CcsB	gnl\|CDD\|274447	TIGR03144, cytochrome_c_biogenesis_protein_chloroplast, cytochrome c-type biogenesis protein CcsB. Members of this protein family represent one of two essential proteins of system II for c-type cytochrome biogenesis. Additional proteins tend to be part of the system but can be replaced by chemical reductants such as dithiothreitol. This protein is designated CcsB in Bordetella pertussis and some other bacteria, resC in Bacillus (where there is additional N-terminal sequence), and CcsA in chloroplast. We use the CcsB designation here. Member sequences show regions of strong sequence conservation and variable-length, poorly conserved regions in between; sparsely filled columns were removed from the seed alignment prior to model construction. [Energy metabolism, Electron transport, Protein fate, Protein modification and repair].	5.92471e-90
NZ_CP049867.1\|WP_166083838.1\|255447_255714_-\|DUF4229-domain-containing-protein	gnl\|CDD\|379415	pfam14012, DUF4229, Protein of unknown function (DUF4229). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 122 amino acids in length.	5.15943e-09
NZ_CP049867.1\|WP_166083832.1\|249771_250446_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	6.53427e-49
NZ_CP049867.1\|WP_166089491.1\|251185_251893_+\|cytochrome-c-biogenesis-protein-CcdA	gnl\|CDD\|280792	pfam02683, DsbD, Cytochrome C biogenesis protein transmembrane region. This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.	3.29471e-42
NZ_CP049867.1\|WP_166083840.1\|256076_256982_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	6.04495e-113
NZ_CP049867.1\|WP_166089498.1\|262789_263437_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|316044	pfam13483, Lactamase_B_3, Beta-lactamase superfamily domain. This family is part of the beta-lactamase superfamily and is related to pfam00753.	1.46274e-18
NZ_CP049867.1\|WP_166089493.1\|257134_258130_+\|AMP-binding-protein	gnl\|CDD\|236108	PRK07824, PRK07824, o-succinylbenzoate--CoA ligase.	8.53735e-98
NZ_CP049867.1\|WP_166083841.1\|259067_260852_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	gnl\|CDD\|236020	PRK07449, PRK07449, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Validated.	4.50304e-161
NZ_CP049867.1\|WP_166083833.1\|250445_251144_+\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	5.3077e-38
NZ_CP049867.1\|WP_166089496.1\|258150_259071_+\|o-succinylbenzoate-synthase	gnl\|CDD\|235084	PRK02901, PRK02901, O-succinylbenzoate synthase; Provisional.	6.22902e-150
NZ_CP049867.1\|WP_166089489.1\|246955_248146_-\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|225501	COG2951, MltB, Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane].	1.83981e-22
NZ_CP049867.1\|WP_166083842.1\|260912_262787_+\|Na+/H+-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	1.65207e-81
NZ_CP049867.1\|WP_166083831.1\|248401_249775_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0

>NZ_CP049867.1|WP_166083835.1|253613_254633_+|c-type-cytochrome-biogenesis-protein-CcsB
MTTEAFASFSDTAIMFAGIVYVLALAAHVAEWVVALTTPARSGGAEGAAAQPVVVGADGSRIDGPAAGAGSGSLPERPADAGDERRELRIDTASRIGVALTVVAAVLHTAGVVTRSFASDPWRVPWGNMYEFTLTGALGVTLIYLVLLRTLRLRWMGLFLTLFQVVVLMLANLTLEQQAGPLVPALHSYWLVIHVGAAILATGAFAVGALTSVMFLVKLRMGERRAALLDRFPDADTLDRISYRLHAVGFPLWTFAALIAGPIWAEYAWGSYWNWDPKEVWAFITWVVYAAYLHARATAGWKGKAAAIIALIGFATLLFNFVGINFFFGASSLHSYAGS
>NZ_CP049867.1|WP_166083834.1|251892_253617_+|cytochrome-c-biogenesis-protein-ResB
MSTRTTDRDPSMPEPPNESGPSDGTDATDARRLASDVPGSPPALSPRELARWAWRQLTSMRTALLLLLLLALGSIPGSVIPQSNIAAVQVGQWKEDHPTLAPIYERLGLFSVYDSVWFSAIYLLLMVSLVGCIVPRLAVHWRAVRSTPPKAPRNLHRLPAYAREELAPGAAAEETLDRAEAALRRRRRYRVVRTGDSLSAERGHLRELGNLVFHISVVVVLLAFAYGQLFGYKGGAIVLVGSGFTNSTPQYDEFAPGSLYDPVDLEPLSFTVDDFDVRFLEGGPANGQPEYFRAPITYREDLDAAPEKHVLEVNKPLVLDGVSVFLVGHGYAPDFTVTDGSGEVAWDAPVPFLPQDATFASFGVLKVQGARPEQLAFDGLFLPTYGFTMERGPFSVFPDARRPVVTMTGYYGDLGLGDGQPQSVYALDTDEMTQFEKGDGTPFRLDMVPGQTVDLPEGMGTVRFNGYERWVKLQISHTPGKGVALGGIVLGLVGLMGSLFVRRRRVWVRVVGGPDGRTSYLEVGGLDRSTVAEGLETEVTGLARTALGTMTGAGDTGRGPGSQASRTRDDEEQP
>NZ_CP049867.1|WP_166089491.1|251185_251893_+|cytochrome-c-biogenesis-protein-CcdA
MALAVPVAAAAGTVSFFSPCVVPLLPGYVSYATGLSGADLETAKRGRMLAGTLLFVVGFTAWFVVVGATAGALGGWLYEYRRTITTVLGVVTILVGLVFMGVVPWLQRDVRLHRVPSVGLAAAPLLGLLFAIGWTPCIGPTLTAVQSMAITEATAGRGALLSVAYSLGLGLPFILLGLSYRRMLGATRWIRKHQAWVTRAGGLMLVAVGLLLVTGWWDLWVAEMRGWVVGFEVSV
>NZ_CP049867.1|WP_166083833.1|250445_251144_+|TlpA-family-protein-disulfide-reductase
MRPTRSSGRPRSEVREPGVATRARRTAGARVTSAAAAALLALTGCTGPSLSSSGEQGFVTSDGSVSVLEPSERKPPQGDVAGETVDGDPVALADFAGDVVVMPVWGSWCGPCIAEAPVLAAAARDLADDGVSFLGINNRDYDAASARQFTENNDLPYDSIYDPEGNLLLSFRGTLPPLSVPTTVVVDAEGRVAARIIGELNTSTLYGVIEDVVGRQLRTPQRSTEAPEGEGA
>NZ_CP049867.1|WP_166083832.1|249771_250446_+|histidine-phosphatase-family-protein
MTTVVHLVRHGEVHNPTGILYGRRPGYHLSDLGRRMATRVAEVISDRDITGVYASPLERAQETAQPLADALGLDLRTDERVIESSNVFEGQTFAGDQRLIQRPRTWRHLWNPLRPSWGEPYQQIVARMTEAVHDVRDAHAGHEAVIVSHQLPIWITRLHLEGKRFLHDPRKRKCTLCSLTSLTFEGDRLTTLTYSEPAGDLIPVHDRNKTFSSGGSPESPGGRT
>NZ_CP049867.1|WP_166083831.1|248401_249775_+|glutamate-1-semialdehyde-2,1-aminomutase
MAGVNLPPPTTPASAPASEALFARARTVIPGGVNSPVRAFQAVGGTPRFVASARGPHLYDADGREYVDLLCSWGPMLLGHAHPEVVAAVSEAVARGTSYGTPTEAEVLLAEEIVARTPVDRLRLVSSGTEATMSAIRLARGFTGRDVVVKFAGCYHGHVDPLLAAAGSGLATFAMPGTPGVPEAVTARTIVLPYNDEAAVTAAFAEHGHEIACLITEATPGNMGVVPPAPGFNRFLSETCAAHGALFVSDEVMTGFRITSSGRWGLDGAVEGWRPDLMTFGKVMGGGFPAAAFGGRADVMAHLAPEGSVYQAGTLSGNPVAATAGHTTLRLATDAVYAHVDRAAETVREAATAALTEAGVPHVAQHDRNMFSVFFSDDDAATPVTDFAGASRQRLDRYAAFFHSMLDSGVHLPPSAFEIWFLSAAHDDAALDRIVSALPAAARAAAAVPDPAPGRTA
>NZ_CP049867.1|WP_166089489.1|246955_248146_-|lytic-transglycosylase-domain-containing-protein
MTTWQKATALVPLALLSGAWTASLAVSSATASDSAEEETAASLPDGSSVPSEAVDQPANISAPGEVAPGVPKGSEDSVVKSASTNGIPSAALSAYQRAAQVIDSADASCNIEWPLVAAIGRVESNHGRYGGNTLSAEGVSTPGIYGIPLNGGNGTQRISDTDAGQYDNDKQFDRAVGPMQFIPSTWSVVGVDGDGDGKRDPQDIDDAALATAVYLCSGDEDLGERAGQESAVYRYNHSDDYVALVLSIMEAYASGDYSAVPNNSTAPTTFTPSYGDSVMGGGTKGFTPPKNPAPRPGGSGSTTAGSGGSSSSGGGSYTPAPAPTQEPAPAPAPTQEVSPEKVVKDTTDKVTNTVKDTTDKVTTGTSNTLSYAQAKAQCLAEGVLALNLESCIDGKM
>NZ_CP049867.1|WP_166083830.1|245895_246879_+|porphobilinogen-synthase
MTVERPVVRQRRLRRTPALRDLVAETSLAARQLVLPVFVREGAAEPVPISSMPGVVQHSRDSLRRAATEAAEAGLGGIMLFGVPTTKDAVGSGAVDPDGILNVAIADVAAEVGDALPVMADLCLDEFTDHGHCGVLTAGGVVDNDATLEVYAEMARAQAAAGAAVVGPSGMMDGQVAVVRDALDGVGRTDVAILAYATKYASAFYGPFREAVDSSLTGDRRTYQQDGRNRIEGVREALLDEAEGADLVMVKPALAYLDVLREVRDAVSVPVAAYNISGEYAMVEAAAANGWIDREAAILETLTSIRRAGADVVLTYWAAEAAALLRR
>NZ_CP049867.1|WP_166083829.1|244154_245888_+|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase
MSHTAPSQQTTTVPTGTTTGTLSGRGTANGRAKVRPGRVSFVGSGPGERDLLTVRAVELLRSAEVVVTEVPEHADLVRQVLGLPAPVLDADGVPVPGDGPELVDGGFGTDGQPLTHAARAKVVVRHAKQGRRVVRLMAGDPFLFASGPEEAQACVKAGIGFEIVPGVSSATSVAAYAGIPLTTKKAREVAVLSCADLKIDWQPYAGDTTLVLLSAVACIGEVAQRLMAAGRSPQTPVAMTRVGTTTEQQTVVSTLATVAVDAEAAAMTPPAITVVGDVVDLRETLSWFETKPLFGWQVLVPRTKEQAGSLSAGLRSHGAVPVEVPTISVEPPRNPLQMDKAVRGLVEGRYEWIAFTSVNAVKAVREKFEEYGLDARAFSGLKIAAVGEKTAASLAEWGLRADLVPTGEQSARGLLEDWPEYDEVLDPINRVFLPRADIATETLVAGLVELGWEVDDVTAYRTVRATPPPAPVRDAIKSGKFDAVVFTSSSTVRNLVGIAGKPHAATVIAAIGPATAKTAEEHGLRVDVLAASPSAEELVEALADFGAARRLALLESGQAVTKPSQRRTTSRRKAGSK
>NZ_CP049867.1|WP_166089487.1|243096_244047_+|hydroxymethylbilane-synthase
MVRVGTRGSALAWTQAGHVADALREHLGVEVELVEVTTHGDVSDAPLATMGGTGVFVGALRSALLEGRCDVAVHSLKDLPTAPAPDIDLVAVPLREDPRDVVVARDGLTLGELPVGSRVGTGSPRRAAQLHALGLGLEVLAIRGNVDTRIGKVASGELDAVVLARAGLARLGRLDEVTEALDPLQMLPAPGQGALALECRSADTALAADLAVLDDPATRAAVTAERRLLADLEAGCSSPVGALADVVEGEDGEELWLRAVVLSLDGGLSVRRSGSAPLAAADELGSSVAAELLDEGAAELDDVPPAPTDLAGRAVP
>NZ_CP049867.1|WP_166083836.1|254765_255014_-|hypothetical-protein
MADSYLSWRSKGSVLSIASNGSVLSVGSVGSVLSVGSVGSALSVLSIGSFGSVAAVLSFASVASVLSDRRRGAVLASAAGQD
>NZ_CP049867.1|WP_166083837.1|255032_255404_+|glyoxalase
MTDDTFRGLHHVQLAVPAGSEDRCREFWGDVLGLTELEKPPVLAARGGCWFRRGGLEVHLGVEEEFVPARKAHPGILVSDIDALAARLGAHGVDVRWDDDFPGMRRFYTSDPFGNRLEMLEPH
>NZ_CP049867.1|WP_166083838.1|255447_255714_-|DUF4229-domain-containing-protein
MREFVLYTAARFGIFGVTYALVLLMVWLVDRNGPLPVLWPLILAAVLSTFLSAYLLRDLRERFAQRVTERADRMSTRFEEMRAREDTD
>NZ_CP049867.1|WP_166083839.1|255800_256055_+|hypothetical-protein
MLKFLLVVALFAGVVYAVAWTLERRRTLGKGNALPRRRPAAPPTKQVAPDDDEDFLRWLDRKRHKDSKDSKDGTDGQGQEPAAD
>NZ_CP049867.1|WP_166083840.1|256076_256982_-|1,4-dihydroxy-2-naphthoate-polyprenyltransferase
MATPAQWLEGARPRTLPAAVAPVLAGTGVAAYVDSAVWWKAALALVVALALQIGVNYANDYSDGVRGTDEDRVGPLRLVGSRVATPGAVKRAAFAAFGVAAVAGLVVAATTAWWLVALGAVCILAAWFYTGGSSPYGYRGLGEVMVFVFFGLVAVVGTTYVQTDGVGTGGAVPLGDWLAPSLLAAVGIGAIACAILVANNLRDIPTDTEVGKRTLAVVLGDARTRLWYVALMVVAVLAAVGVAVLTSPWALLALLALVPGTRAVAVVRGGAVGRALVPVLQLTGVTELLYGLGLFVGLLVA
>NZ_CP049867.1|WP_166089493.1|257134_258130_+|AMP-binding-protein
MLALLRAWDAAPEEPEPLVLRTSGSTGRPKSVVLSRAALRASAHATHDRLGGAGQWVLNLPPTYVAGLQVLFRSVVAGTDPVLQTGSLAETVAEMTGPRRHVSLVPTQLRRLLDDPAELAALARFDAVLVGGGPLRPEVRATAETAGVRVVQTYGMAETCGGCVYDGHPLDGVEVRTGGDGQVLLRGSVLFDGYADDPDRTATVMDDGWLRTQDLGRLDEDGRLWILGRADSVVISGGVNVPAEAVEAMIEQHPEVEDVVVVGVPDEEWGERVTAVVAARRPLGLAELRDLVEPRAWAPRALVATDAMPHLPNGKVDRRAARALADQQVRP
>NZ_CP049867.1|WP_166089496.1|258150_259071_+|o-succinylbenzoate-synthase
MRTRFRGIDVREGMLLRGDAGWGEFSPFLEYDERVAEPWLRAALEAADEGWPTPLRDSVPVNVTVPAVEAERARATVLAGGCTTAKVKVAEPGQHLADDEARVEAVRDALGPGGRIRVDANGAWSVDEAVTAIRRLDRAAGGLEYVEQPCASVEDLARVRRRVDVPIAADESIRRAEDPYRVRELEAADVAVLKVQPLGGVRACLRIAEDIGLPVVVSSALETSVGIAAGVALAAALPTLEHACGLATVQLLTADVVHRPLLPVDGALPVERPQVDPVRLAAVAPAPDRVAHWEARLAAIRQDRRS
>NZ_CP049867.1|WP_166083841.1|259067_260852_+|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase
MSPDPDPDRDSAPVNAATAQARTLLDELVRGGVAHVVVCPGSRSAALAFAAHAAASRDDLTLHTRLDERTAGFLALGLARTSRRPVAVVTTSGTATANLHPAVLEASHAGLPLVVLTADRPAHLRGTGANQTTDQVHLYGTATRLFADVPAGAPGHSEDQQVAGWRSLVARALAAASGHAGPPPGPVHLNVQLDGPMTPDAPDGWSSDAPGRARDLPWTRSTRPREALVPRPAATAPAEEDPWDDDVPTVVVAGDDAGPPARVLAEERGWPLLAEPSSGSRTGANAVRTYRLLLGDADLAGRIRRVVVAGHPTLSRPVTRLLSRDDVEVVALRDRLGGWTDPGHRVSRVLDQAPLRPATAPGAPRAERPAPGPWLREWLDRDADVGARLDALLDATGDLTPQHVAGEVAAALVPGGLLFVGASNPVRDLDLMVPRYDVGARRMVVANRGLSGIDGIVSSAIGAALGRPRSTRSLALVGDVTFLHDTTGLVLGPDEARPDLTIVVVNDDGGSIFALLEQGAPEHAGSFERLFATPHGVDLASLCAATGTTYVRAGDRAELRAALAREPQGILVVEAVVRRDTRRDLDAAIRALVG
>NZ_CP049867.1|WP_166083842.1|260912_262787_+|Na+/H+-antiporter
MHVALLLVALVVTIVTVAAVARRLDFPAPLLMVAVGVLASYLPVVPEIRLTPEIVLVGLLPPLLYNAALSTSLVDFNTYRRPILGLSVGLIIFTTFGVGLLLHTIVPDLSWGAAFAIGAVVAPPDAVAATAVGRRIGMPRPVVTVLEGESLLNDATALVALNTAIVAATATISVVEVGLDFLLAAVGGVACGLLVFVVVAQVRRHVTEPTLDTSVSIVTPFIAYVVAEEIHASGVLAVVVAGLALGHKAPLLQTPSSRIAERLNWRTFAFLLENAVFLLIGLQTSWIVGEVSESPLSTATIVGACVATLVAVIVLRYLWLLPARFVLLKPDPSGRKPPPAYTVIVGWAGMRGVVTLAAAFAIPEEVPGREVLLLIALFVTGATLLIHGLTLPWLVRALKVRPPDPREDALARAELLQAASRAGLDRLEEVEDDGDLHEGVRQVLHSRIEQREFAAWERLGAEQNEGETPSERYARLRGDMLAAERARVLELRSTGRIPHEVVEDVLSSLDIEESMIDYGVQRHREFVRKQERSDVVSRAVDACDHLTEAPDREAPEERACEDCVREGSSWVHLRMCLDCGHVACCDSSPRRHAAAHFHAEDHPVIRSVEPGEAWRWCYADEVVG
>NZ_CP049867.1|WP_166089498.1|262789_263437_+|MBL-fold-metallo-hydrolase
MRITKFSHSCVRLSSGEGPGRDVVVDPGAWSERESLDGAAAVLITHEHPDHWTIEHLQASDAPIWTIEAVARQIREADAGVGERVTVVTPGEQLEIAGYDVRVVGEKHAVIHPEAPEFANSGFVLSADGTSVYHPGDSFELPGQDVDVFLGPACAPWARMSELVELARAVGAPRTLGIHDEVYSAKGLGIVDRFMNDFLGKQDGSWSRLAPGTDL

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Crispr_ID: NZ_CP049867_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_6

948636-948771

Orphan

Consensus_repeat	Method
CGGTGGTCGAGCAGCGAGCGCCAGCGAGCGTCGTCGAAACCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_6

>merge|NZ_CP049867|6|948636-948771|CRISPRCasFinder
CGGTGGTCGAGCAGCGAGCGCCAGCGAGCGTCGTCGAGACCTGGTGACCTGGGCAGGGTCTCGACGTCGGTTGCTGCGCAACCTGCTCGACCACCGGTGGTCGAGCAGCGAGCGCCAGCGAGCGTCGTCGAGACCT

>NZ_CP049867|6|6|948636-948771|CRISPRCasFinder
CGGTGGTCGAGCAGCGAGCGCCAGCGAGCGTCGTCGAGACCT	GGTGACCTGGGCAGGGTCTCGACGTCGGTTGCTGCGCAACCTGCTCGACCAC
CGGTGGTCGAGCAGCGAGCGCCAGCGAGCGTCGTCGAGACCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166084437.1\|944375_945683_-\|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236426
NZ_CP049867.1\|WP_166084448.1\|953973_954741_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293802
NZ_CP049867.1\|WP_166084435.1\|942888_943659_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|235852
NZ_CP049867.1\|WP_166084444.1\|948939_949728_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP049867.1\|WP_166084450.1\|955450_956656_+\|DUF1624-domain-containing-protein	unknown	unknown	gnl\|CDD\|377915
NZ_CP049867.1\|WP_166084436.1\|943766_944342_-\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238493
NZ_CP049867.1\|WP_166089665.1\|941841_942621_-\|L,D-transpeptidase	unknown	unknown	gnl\|CDD\|341130
NZ_CP049867.1\|WP_166084441.1\|946660_947104_+\|M67-family-metallopeptidase	unknown	unknown	gnl\|CDD\|163701
NZ_CP049867.1\|WP_166084442.1\|947204_947492_+\|MoaD/ThiS-family-protein	unknown	unknown	gnl\|CDD\|340594
NZ_CP049867.1\|WP_166084443.1\|947502_948450_+\|cysteine-synthase	unknown	unknown	gnl\|CDD\|273463
NZ_CP049867.1\|WP_166084449.1\|954749_955451_+\|DUF3152-domain-containing-protein	unknown	unknown	gnl\|CDD\|371483
NZ_CP049867.1\|WP_166084447.1\|953120_953933_+\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851
NZ_CP049867.1\|WP_166084446.1\|950498_952862_-\|peptidase-M6	unknown	unknown	gnl\|CDD\|368494
NZ_CP049867.1\|WP_166084452.1\|957342_958641_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP049867.1\|WP_166084438.1\|945739_946036_+\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NZ_CP049867.1\|WP_166084451.1\|956689_957346_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP049867.1\|WP_166084434.1\|940911_941553_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166084453.1\|958769_959669_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP049867.1\|WP_166084445.1\|949787_950459_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP049867.1\|WP_166084439.1\|946040_946625_+\|DUF2017-domain-containing-protein	unknown	unknown	gnl\|CDD\|378185

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166084437.1\|944375_945683_-\|nicotinate-phosphoribosyltransferase	gnl\|CDD\|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NZ_CP049867.1\|WP_166084448.1\|953973_954741_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293802	cd07716, RNaseZ_short-form-like_MBL-fold, uncharacterized bacterial subgroup of Ribonuclease Z, short form; MBL-fold metallo-hydrolase domain. The tRNA maturase RNase Z (also known as tRNase Z or 3' tRNase) catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Two forms of RNase Z exist in eukaryotes, one long (ELAC2) and one short form (ELAC1), the former may have resulted from a duplication of the shorter enzyme. Only the short form exists in bacteria. Members of this bacterial subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	2.10144e-82
NZ_CP049867.1\|WP_166084435.1\|942888_943659_+\|enoyl-CoA-hydratase	gnl\|CDD\|235852	PRK06688, PRK06688, enoyl-CoA hydratase; Provisional.	2.97962e-83
NZ_CP049867.1\|WP_166084444.1\|948939_949728_-\|HAD-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.04242e-121
NZ_CP049867.1\|WP_166084450.1\|955450_956656_+\|DUF1624-domain-containing-protein	gnl\|CDD\|377915	pfam07786, DUF1624, Protein of unknown function (DUF1624). These sequences are found in hypothetical proteins of unknown function expressed by bacterial and archaeal species. The region in question is approximately 230 residues long.	3.44913e-06
NZ_CP049867.1\|WP_166084436.1\|943766_944342_-\|isochorismatase-family-protein	gnl\|CDD\|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	3.9596e-70
NZ_CP049867.1\|WP_166089665.1\|941841_942621_-\|L,D-transpeptidase	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.4774e-23
NZ_CP049867.1\|WP_166084441.1\|946660_947104_+\|M67-family-metallopeptidase	gnl\|CDD\|163701	cd08070, MPN_like, Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding). This family contains archaeal and bacterial MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+)-like domains. These domains contain the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, EXnHS/THX7SXXD, which is involved in zinc ion coordination and provides the active site for isopeptidase activity for the release of ubiquitin from ubiquitinated proteins (thus having deubiquitinating (DUB) activity) that are tagged for degradation. The JAMM proteins likely hydrolyze ubiquitin conjugates in a manner similar to thermolysin, in which the zinc-polarized aqua ligand serves as the nucleophile, compared with the classical DUBs that do so with a cysteine residue in the active site.	4.05826e-37
NZ_CP049867.1\|WP_166084442.1\|947204_947492_+\|MoaD/ThiS-family-protein	gnl\|CDD\|340594	cd17074, Ubl_CysO_like, ubiquitin-like (Ubl) domain found in Mycobacterium tuberculosis CysO and similar proteins. CysO, also termed 9.5 kDa culture filtrate antigen cfp10A, together with CysM (Cysteine synthase M), forms a protein complex CysM-CysO that represents a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. The replacement of the acetyl group of O-acetylserine by CysO thiocarboxylate to generate a protein-bound cysteine is catalyzed by CysM in a pyridoxal 5?-phosphate (PLP)-dependent manner. The family also includes QbsE that functions as the sulfide donor for the biosynthesis of thioquinolobactin in Pseudomonas fluorescens. A JAMM motif protein QbsD catalyzes removal of the carboxy-terminal dipeptide from QbsE. Both CysO and QbsE are similar to prokaryotic sulfur carrier proteins such as ThiS and MoaD, containing the beta-grasp ubiquitin-like fold.	8.85235e-38
NZ_CP049867.1\|WP_166084443.1\|947502_948450_+\|cysteine-synthase	gnl\|CDD\|273463	TIGR01136, Cysteine_synthase, cysteine synthase. This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family].	4.31201e-132
NZ_CP049867.1\|WP_166084449.1\|954749_955451_+\|DUF3152-domain-containing-protein	gnl\|CDD\|371483	pfam11350, DUF3152, Protein of unknown function (DUF3152). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	1.38706e-22
NZ_CP049867.1\|WP_166084451.1\|956689_957346_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.12966e-67
NZ_CP049867.1\|WP_166084446.1\|950498_952862_-\|peptidase-M6	gnl\|CDD\|368494	pfam05547, Peptidase_M6, Immune inhibitor A peptidase M6. The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.	3.31976e-17
NZ_CP049867.1\|WP_166084452.1\|957342_958641_-\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	5.34078e-29
NZ_CP049867.1\|WP_166084438.1\|945739_946036_+\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	1.20258e-35
NZ_CP049867.1\|WP_166084445.1\|949787_950459_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	3.82351e-56
NZ_CP049867.1\|WP_166084453.1\|958769_959669_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	6.74008e-92
NZ_CP049867.1\|WP_166084447.1\|953120_953933_+\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	1.61961e-126
NZ_CP049867.1\|WP_166084439.1\|946040_946625_+\|DUF2017-domain-containing-protein	gnl\|CDD\|378185	pfam09438, DUF2017, Domain of unknown function (DUF2017). This is an alpha-helical domain found in gene neighborhoods that contain genes encoding ubiquitin, cysteine synthases and JAB peptidases.	8.93489e-55

>NZ_CP049867.1|WP_166084443.1|947502_948450_+|cysteine-synthase
MRFDNLLDSVGGTPLIGLPRLSPSPEVRLWAKLEDRNPTGSIKDRAALKMVEQAEKDGLLTPGCTILEPTSGNTGISLAMAAKLKGYRIVCVMPENTSIERKQLLGMWGAEIISSPAAGGSNEAVRVAKRIAGENPDWVMLYQYGNPANALAHYEGTAPEILADLPSVTHFVAGLGTTGTLMGTSRYFREHKPDVRIVAAEPRYGELVYGLRNLDEGFVPELYDASLIDSRFSVGPHDAVRRVRELLEHEGIFAGISTGAILHAALGQARKAEKAGESADIVFIVCDGGWKYLSTGAYEGTLEEAEERLDGQLWA
>NZ_CP049867.1|WP_166084442.1|947204_947492_+|MoaD/ThiS-family-protein
MAIEVRIPTILRTYTDGAKAVNGEGATLSALIDDLEERHTGIKDRLVEDKDGQSDLRRFVNVYVNDEDVRFTGGLGTELGDGDQVVVLPAVAGGA
>NZ_CP049867.1|WP_166084441.1|946660_947104_+|M67-family-metallopeptidase
MLVIDQKTYDAIVAHARRDHPDEACGIVAGPEGSDRAERMVEMTNAAGSPTFYEFDSTELLELYKQMWDNDEEPVVVYHSHTATEAYPSRTDIGLASEPGAHYVLVSTREHGNNEGPVEFRSYRIVDGQVTEEDVDVVDALPARKTA
>NZ_CP049867.1|WP_166084439.1|946040_946625_+|DUF2017-domain-containing-protein
MTEGFHPRRGGGVVATFSGFEADLLRSLASQLIELLRNEAAVPHAEADPLEALLDFTGPTTAPEDPVLARLFPTAYPQDEEAAGEFRRFTETELRGGKAGNAAAVIDVLEEAGLPGDLEGEALVIDVELDHGGAMQWMKSMTDMRLALASRLDITEGDEDYWDSLPDDDARVHVHDIYDWLGFLQESLVRAVAP
>NZ_CP049867.1|WP_166084438.1|945739_946036_+|ATP-dependent-Clp-protease-adapter-ClpS
MSTPAPLEVEEPVADELTATDRPWQTVVWNDPVNLMSYVTFVFRQYFGFTEKKAEKLMLQVHHDGRCTVSSGSREEMERDVQAMHEYGLWATLERAEG
>NZ_CP049867.1|WP_166084437.1|944375_945683_-|nicotinate-phosphoribosyltransferase
MSDPAGASTALLTDHYELTMLQAALAAGTASRRSVFELFPRRLPDGRRYGVVAGVGRALDALGRFVFDEPALAFLRDNGVVDEATVAWLADYRFTGDVWGYPDGEVYFPHSPLMVVEASFAEAVVLETLLLSILNHDSAIASAGSRMTWAAGERPCIEMGTRRTHEEAAVACARAAYLTGFTATSNLAAGQRFAIPTTGTSAHSFTLLHDTERDAFTAQVDSLGRGTTLLVDTYDIAEAVRLAVEVAGPELGAVRIDSGDLGLLAQQVRAQLDSLGAHATRIVVTSDLDEHAIASLAAAPVDGYGVGTSLVTGSGHPTCGFVYKLVAREGADGAMVDVAKKSKDKISVGGRKFALRRRSAAGVAEAEMVGIGTPPVDDGDDRALMVELVRDGEVVGRESLEAGRERHRTSREELPMQARQMSRGEPVLPTVFLPR
>NZ_CP049867.1|WP_166084436.1|943766_944342_-|isochorismatase-family-protein
MKRALIVVDVQNDFCEGGSLPVFGGADVARRITELLHRWSAGGPDAPEYAVAVATQDHHIDPGHHFSAAPDFVDTWPPHCVSGSDGVAFHPNLDPEPFDAVFRKGEFAAAYSGFEGSDAEGVALADWLRRQEVTDVDICGIATDYCVRATTLDALKQGFGTRVLTDLCAGVQPGTSAAAIDEVRNAGAAVA
>NZ_CP049867.1|WP_166084435.1|942888_943659_+|enoyl-CoA-hydratase
MSHLEVQTAGGVRRITFTRPEAFNAMSEEMAAGLVDALDSAADDEAVRVVLVTGTGAAFSAGVDLTGDDPVTNFDDSTLVGANTIIRSVTGLPKPVVAGVNGIAAGVGASIVFACDLQVTTSSAGFLLAFSRIGLMPDGGSSLTVAASVGRARAMRLALLGETLGAQEAFDAGLVSHVVADDDYDEQLEKVVSRLARGPALAFARTKDAVNTATLGGLEDALERERAGQVALFATHDASEGMKAFVGKRRADFQGR
>NZ_CP049867.1|WP_166089665.1|941841_942621_-|L,D-transpeptidase
MRGGDSELVAEQPRREARADKPKAQRSEPGRTMQKATPPPLDLASLTPATTNTTLPDAPLDRSLAETEGDVVRPTTTLAVYATPGKRPFAKVPPQQFQDTWLPVVGREDGWVKVLLPSRPNGASGWLRESRVETARSPYVVRVHLTSRTIDIVYDGSTLGTWPVAIGEPSTPTPPGRTFLLGSVIDDNQSYSPIILPLGSHSDTLDSYGGGPGTVALHGWPDESVFGTAASHGCIRVPAEALDLLTQVPLGTLVIVDER
>NZ_CP049867.1|WP_166084434.1|940911_941553_-|hypothetical-protein
MTAGDDFASVELTNLEVAPSSEQLPAEVQAILTQLEDGCAQVTAGLPDPPATGLPPIPGVPPEVNDLLADLLPEGAGLDDLEGFCDSFDPTAPLVSIGVLSVDCEGDQGGVELARLSFLGQQVPVPAVAQNQAIVPENPLVTITANRQSTTDDGGFSVDGLAITLGDGEATGAEAIVANATCGEAIAAPAVDTPAPPAAPAPAPVAGTAPVTG
>NZ_CP049867.1|WP_166084444.1|948939_949728_-|HAD-family-hydrolase
MTSPTRPIETWLTDMDGVLVHEEEAIPGAPEFIAALERSGKKYLVLTNNSIFTPRDLRARLRSSGIDVPEHAIWTSALATAQFLDEQRPQGKAYVVGEAGLTTALHEIGYVMTDRDPDYVVLGETRTYSFEAITRAIRLIDAGARFIATNPDVSGPSPQGKLPATGAVAALISSATGREPYYVGKPNPLMMRSALNRLEAHSETTIMIGDRMDTDIKSGLEAGLRTVLVTSGSTSPEDVDAFPYRATQTFGSVADLIEFVEE
>NZ_CP049867.1|WP_166084445.1|949787_950459_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MMYRLVDSVVSPLARAVWRPTVEGVEHVPATGPVLLASNHLSFFDSVVIPVVAPRKVVFLAKDDYFNNPGLKGRAQRAWFEGLGMVPVDRDDTRAAIDSLQIALEVLGRGEAFGLYPEGTRSRDGRLYRGKVGVAQLALQSGAPIVPVGLIGTDRLQPVGSSVPRLAKVTVRFGEPIRVAGEYDGVAPGRARREIADRVMTAIQALTGQEQAGVYNERPADPH
>NZ_CP049867.1|WP_166084446.1|950498_952862_-|peptidase-M6
MRRPSRTASRRPTLWTAALTGSAVAIALGLPTLPAGAAPAPAPDPSGPASAAPSGTDDTREFVPSAKTPRLDRGESVTARRQARADATGAPQVGDTRSWLANDDIYGPYLKRYVLRGMGDNVQVWVANDRAFPTDDCRNDLGLTEITKKQVSSFVDEFSTTMYPRESKVFSVPPDRNGADSSAAALGLDADYWKVPRKQADDIVVLVDNVRDGNYYAPATPDGQTFIAGFFWSYFNELADRNIMTIDAYDWIHRTGVNPPDNSTEADYEACAEELDQPTTNFGISRPQDYEGTFAHEYQHLLEYYEDEDEVNWVNEGVSDWAQTLTGYTDPRVNVSADGADRHMACFAGYLGRRFGGPENSMTLWGEQGGPEILCDYGAAYSFMEYLHSLYGNAIMTKLHRLDANGLRGLQRALDAVGARGDAMTHLHRWAVMVAIDRPIDRDGGRLTGGNPDAFTADSLSFHVKWANPESYGDAGAPANGADYVRLRNDGGDWLAADEISSLRFNGSDTALGEPVEWAVDSTPPATADGEDDTCATPPADGSGAPALYSGCGDNLDRSIARTVSVPEGDPTLSFDSLSDIEEAWDFGIVQVSEDDGQTWTTVPTTDSTSEHDPDADPAIVAQLPGLTGSSDGYRTQTADLSDWAGEDVLLAFRYMTDGAQAEAGWWVRNIDVGGTAIPATLDGWRTQTQIDPDPVADWTVQLVAYGAAGDPVRYHRMALDPSHSGVLSGDALRQAIGDDATTVAAIVMQDDPREVARYQAGYQLVADGTLQPGGGIPGCFPGARCR
>NZ_CP049867.1|WP_166084447.1|953120_953933_+|glutamate-racemase
MADAPIGIFDSGFGGLTVARSVIDQLPHESVLYLGDTARQPYGPKPIGAVREYALDCLDHLVDQGVKLLVIACNSASAAVLRDARERYPVPVVEVIFPATRRAVAASRTGRIGVICTRATAESMAYDDAFAAAPHVELTTQACPRFVDFVEAGVTSGPDLIGVAHDYLDPLVSQGVDTLILGCTHYPLLTAVLAYVMGDQVTLVSSAEETAKDVYRTLVRRGLERDPDLGPPTYRFLTTGQPEEFGRIGRRFLGPELVTADQLAWVRAGA
>NZ_CP049867.1|WP_166084448.1|953973_954741_+|MBL-fold-metallo-hydrolase
MKVTVVGCSGSYAGPESSASCYLVEAEDPQTPGRTWRLLLDLGSGSLGPLHRYVDPLTIDALVISHLHADHFFDISGYYVMRKYHPTGAQARIPVWGPRGTKSRVARAYGLPLDPGMNEEFRFRRIKREPITLGPFTITPRRVDHPIEAYAFRVEAGGRTLVYSGDTAACEELTALARGADLLLCEAAFRDDADNPPHVHMTGSEAAATAQAAGVAALVLTHVPPWHDRQDALLEAEGVFDGSTVLAAEGSTYQV
>NZ_CP049867.1|WP_166084449.1|954749_955451_+|DUF3152-domain-containing-protein
MTTTTRTTRNPPTRTVACVAALLLTLVLGSAALPGAHAREQAAPEGEPAGAPSAAPTVLPQVTLEASRPRAPARHVVRYRVETRGRIVASTAVFRRQVQETFDDRRGWRASGIEFRRVATGGTLSVVLSEASKVPTFSSGCSAQWSCRVGRYVVINQMRWNGASTMWRNKGRTLRSYRHMVVNHETGHWLGLGHRGCPRPGSLAPVMMQQSVDLQGCRPNPWPLPGERNVPRF
>NZ_CP049867.1|WP_166084450.1|955450_956656_+|DUF1624-domain-containing-protein
MAGVSSSRLVGLDLARLVALLGMVAAHLLTGVVDGRVTLTHQVVAGRSSGLFALLAGLAIVLLARTREPVRGLAWRAEQAAALARAVGLGALGLLLGGLVDTGMSVILAYYAVLFALATPFLALRTRWIALAAGVLVLVGPPLSQVLRSVLPRDRPSDPTPASLLDPLDLLQELLLTGSFPVLTWLPFVLAGMVVGRLDLRSVDVTRRLTAVGAGLVLLAWVAADLFLAVPGVREQLERSVARPGGPADLELILSRGFKAVLPTDTWAWLLVRAPHSGAWLDQVNVIGSSCLVIGLCLAVGRRVPERLVVLTGAGSLTLTLYTLHVVSRDRGLVPVDGPDQLLPQVLVMLALGALAHRLGRRGPLEAVLTRMSRAARAAVVVAVPEAEPDVPGVTVRGGRG
>NZ_CP049867.1|WP_166084451.1|956689_957346_-|response-regulator-transcription-factor
MTPTRILVVDDDPLVRSGLALILGGAPDLEVVGEAADGAEALVAARALRPAVVLMDLRMPRVDGLEATRALTALPEPPLVVVLTTFDVDDAVVRALEAGASGFLLKDTPPPDLVDAVRRAAAGEPMLSPTATRRLIERVTAGTDPVRRARARDRVGALTEREREVAVAVGRGLGNAEIADQLHLSVATVKAHVGRLFTKLGVENRVQVALIVNDAEGA
>NZ_CP049867.1|WP_166084452.1|957342_958641_-|histidine-kinase
MHLPARAGASGPPPFAHPPRISARGHAWRIAIVLVVSALGWFETGHLQWDQAPWLFVLDLVLGVASFVAMFFRRRHPLGVAVAVTLAGAASYSSAGPAVLVTVSLATRRRWPEILGVGALGVVVALVFTGYQPVPPTPAWVSVGFLLVVTVALMALGMYIGSQRELMWTLQDRARRAEEQQAARVAQARAGEREQIAREMHDVLAHRISLVAMHAGALAYRTDLGAEAVRSSAGLIQHQAHEALTDLRAVLNVLREEVSPDAVPVALRPQPTYADLPALVLDARQAGMQVSLHVDEASDLPDALGRAVYRVVQEGLTNARKHAPHAHADVEVRRRPEEVVVTVANSTGPARPRVPGAGLGLVGLRERVDLAGGALEHGVRGDRFVLCARLPVHDTAPSLAEDGPGPDAAVPATATASGGGGGGGGGRDRVVP
>NZ_CP049867.1|WP_166084453.1|958769_959669_+|ATP-binding-cassette-domain-containing-protein
MISVQGLTKTYGGFRAVDDVSFVAAPGRVTGFLGPNGAGKSTTMRMMTGLTVPTSGRATIGGHAYRDIPNPGRHVGVLLDASAQHAGRTGREVLALGAGVLDLPRSRVDEMLETVSLTRQEARRRVKDYSLGMRQRLGIAHALLGDPEVLVLDEPANGLDPAGIHWMRTLLTDYARRGGTVLLSSHLLHEVEVIADDLVVIGQGRIVAQGTKTELLQSTGTVVRAVDDAALERALAEAGISSVASPDGARRTEAEARQVGEAAAHHGVVLLELRAADGAGLEELFLTLTSQTQREGAAA

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Crispr_ID: NZ_CP049867_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_7

1064796-1064927

Orphan

Consensus_repeat	Method
GATCTCGACGACGGGCGCGGGGCGCCCTGCTCGATCACCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_7

>merge|NZ_CP049867|7|1064796-1064927|CRISPRCasFinder
GGATCTCGACACGGTCGCTGCGCTCCCTGCTCGATCACCGGGGGCCTGGGCGGCGACCTCGCCGGATCTCGACACGGTCGCTGCGCTCCCTGCTCGATCGACGGGGGTGGGGCTCCCTGCTCGATCACCCGT

>NZ_CP049867|7|7|1064796-1064927|CRISPRCasFinder
GGATCTCGACACGGTCGCTGCGCTCCCTGCTCGATCACCGG	GGGCCTGGGCGGCGACCTCGCCGGATCTCGACACGGTCGCTGCGCTCCC
TGCTCGATCGACGGGGGTGGGGCTCCCTGCTCGATCACCCGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166084548.1\|1070233_1070995_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235500
NZ_CP049867.1\|WP_166084544.1\|1066483_1067077_+\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|213983
NZ_CP049867.1\|WP_166084545.1\|1067198_1068896_+\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271372
NZ_CP049867.1\|WP_166084552.1\|1076431_1077622_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP049867.1\|WP_166084542.1\|1062534_1063026_-\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|176867
NZ_CP049867.1\|WP_166084546.1\|1068906_1069239_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166083598.1\|1060922_1061201_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166084538.1\|1058397_1058547_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166084540.1\|1059688_1060336_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP049867.1\|WP_166084541.1\|1061159_1062302_+\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NZ_CP049867.1\|WP_166084550.1\|1072258_1074793_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP049867.1\|WP_166084547.1\|1069320_1070139_+\|DUF1206-domain-containing-protein	unknown	unknown	gnl\|CDD\|377695
NZ_CP049867.1\|WP_166084549.1\|1071057_1072062_-\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|187558
NZ_CP049867.1\|WP_166089705.1\|1065307_1066375_-\|YbdK-family-carboxylate-amine-ligase	unknown	unknown	gnl\|CDD\|237408
NZ_CP049867.1\|WP_166084536.1\|1056439_1057765_+\|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|234685
NZ_CP049867.1\|WP_166084539.1\|1059290_1059674_+\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|376779
NZ_CP049867.1\|WP_166084543.1\|1063136_1064408_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP049867.1\|WP_166089703.1\|1058634_1059294_+\|nicotinate-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
NZ_CP049867.1\|WP_166084551.1\|1075410_1076421_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NZ_CP049867.1\|WP_166084537.1\|1057748_1058387_+\|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|376450

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166084548.1\|1070233_1070995_-\|SDR-family-oxidoreductase	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	8.13192e-86
NZ_CP049867.1\|WP_166084544.1\|1066483_1067077_+\|hemerythrin-domain-containing-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	6.97574e-11
NZ_CP049867.1\|WP_166084545.1\|1067198_1068896_+\|sodium:solute-symporter-family-protein	gnl\|CDD\|271372	cd11478, SLC5sbd_u2, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NZ_CP049867.1\|WP_166084552.1\|1076431_1077622_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.49829e-66
NZ_CP049867.1\|WP_166084542.1\|1062534_1063026_-\|polyketide-cyclase	gnl\|CDD\|176867	cd07825, SRPBCC_7, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	3.27602e-39
NZ_CP049867.1\|WP_166084540.1\|1059688_1060336_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.14959e-52
NZ_CP049867.1\|WP_166084541.1\|1061159_1062302_+\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	6.50817e-102
NZ_CP049867.1\|WP_166084550.1\|1072258_1074793_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP049867.1\|WP_166084547.1\|1069320_1070139_+\|DUF1206-domain-containing-protein	gnl\|CDD\|377695	pfam06724, DUF1206, Domain of Unknown Function (DUF1206). This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.	9.60256e-15
NZ_CP049867.1\|WP_166084549.1\|1071057_1072062_-\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.10846e-120
NZ_CP049867.1\|WP_166089705.1\|1065307_1066375_-\|YbdK-family-carboxylate-amine-ligase	gnl\|CDD\|237408	PRK13517, PRK13517, glutamate--cysteine ligase.	9.4639e-102
NZ_CP049867.1\|WP_166084536.1\|1056439_1057765_+\|glutamate-5-semialdehyde-dehydrogenase	gnl\|CDD\|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	0
NZ_CP049867.1\|WP_166084539.1\|1059290_1059674_+\|ribosome-silencing-factor	gnl\|CDD\|376779	pfam02410, RsfS, Ribosomal silencing factor during starvation. This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.	6.79456e-45
NZ_CP049867.1\|WP_166084543.1\|1063136_1064408_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	8.55071e-13
NZ_CP049867.1\|WP_166089703.1\|1058634_1059294_+\|nicotinate-nucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	1.10461e-92
NZ_CP049867.1\|WP_166084551.1\|1075410_1076421_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	7.5574e-32
NZ_CP049867.1\|WP_166084537.1\|1057748_1058387_+\|CDP-alcohol-phosphatidyltransferase-family-protein	gnl\|CDD\|376450	pfam01066, CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.	1.32525e-06

>NZ_CP049867.1|WP_166084543.1|1063136_1064408_+|alpha/beta-hydrolase
MTEHPTAGQRREVAGVVVTDHWLDLPLDHADPTGPTIEVFGREVAAPGGFDRPLLVFLQGGPGHEAPRPTGFPAAPAWLERALQDHRVLMLDQRGTGLSTPYGDPDPDPAADANRLRHFRADAIVRDAEAFREHLGERKVSLLGQSFGGFCTLHYLSSAPDSVRAAIFTGGLPVVGRPVDDVYAATFTQMRRLNELHHRRYPMDRDRLARLLALCDAGEVLDPEGRPLSRRMVRTIGNRLGFDGGSEELHYLLERDPHSAAFRHDVVGLFPFGARNPMYAVIHESSYADGVITGWSAARVQPDDFAAADSLLLTGEHLFPWHFEEDPALRPYAEVAGLLADEAWPKLFDAGVLADLDVPAAAVVYAEDPFVDRGLSLQTAALVPSLRTWVTDQYLHGGLRHGGGDLLDRLLGMTKAAVAVRGD
>NZ_CP049867.1|WP_166084542.1|1062534_1063026_-|polyketide-cyclase
MSECLETSRLIPAPASEIFALLCDPQGHVAIDASGMLQDATGEPVTAVGDSFVVHMDREALGDLPDWGRYDVTVRIEELEPDQLITWSILGRIRPQIGHRYGYRLEPAEEGTRVTSIYDWSEARQDFKDNGVFPVISEANLRATLGILDRTVRRGYPAADART
>NZ_CP049867.1|WP_166084541.1|1061159_1062302_+|uracil-DNA-glycosylase
MLFYACPDVVETSHVSILGQAPRNRHIAVGGPRHDRGTADRGRHCDQCEHSEEARERAPARRGFKPGGAPRFQKQAARRLDRRLPRPRPPQRDADRGRTGRDGRWRGAHHRLDARCGGSSDGIVGAQPVRIGGRRVGSRRREALLADVDPEEAAGLAALARTRRPWPGVLDDELEKPYFRDLMGMVDRGRRTGVVYPPAGDLFAAFHLTPYDKVKVVILGQDPYHQPGQANGLCFSVPRDVPRLPPSLRNIYAMMTRDGLTPPPHGDLTEWAQRGVLLLNTALTVRDSRANSHAKQWRQFADAAITKLSDRDRPVVFVLWGKAAQRKRDLIDEDRHAVVTAPHPAARGRSQTEFREAKTLTEVNRRLDTLGVTPVDWAIT
>NZ_CP049867.1|WP_166083598.1|1060922_1061201_-|hypothetical-protein
MASFDDVWTRIEQHAGQQFITATGLPFTYRVPGDYLKVSRDGREINRSLSRTNFMKAAAAMPTSKPSDIKDRQGSAYTWAILMDPRVRAGAW
>NZ_CP049867.1|WP_166084540.1|1059688_1060336_+|histidine-phosphatase-family-protein
MSQQPSKRLFLLRHGRTEWNHTRRAQGQANVPLDEVGHAQAQAAAPRLALVGAVRLWSSDLARARQTADHVAAATGLTVEEDPRLREFSVGEREGMTWDEAVAEFPQMADGISLGERLKGVPGAEDNDDVRARIVPAVEDCFAALSWGETGIAVSHGAALKLALGGLLGWDEHAVNSLGVLDNCHWATVLEPGEGRARRLLAYGVGDFASATTIG
>NZ_CP049867.1|WP_166084539.1|1059290_1059674_+|ribosome-silencing-factor
MTATDHALELVRAAAQAASDKLAEDVIAFDVSDQLVITDAFVLASASNDRQVKAIVEAVEDSLRELGAKPVRREGERDGRWVLMDYAEIVVHVQHEEERAFYALERLWRDCPLIELPESVTSTRRSS
>NZ_CP049867.1|WP_166089703.1|1058634_1059294_+|nicotinate-nucleotide-adenylyltransferase
MGGTFDPIHHGHLVAASEVQAWYDLDEVVFVPTGQPYQKAERSVSPAEHRYLMTVIATASNPRFTVSRVDIDRDGPTYTVDTLSDLAAVFPDADLYFITGADALQDILGWRAADDLFELAHFVGCTRPGYAMDHGTLAGMPHDRVTIVEIPALAISSTDCRARTARGEPVWYLVPDGVVQYITKHRLYLSDRPSAPEALGPSPEPDPEPTDRTTPQGVS
>NZ_CP049867.1|WP_166084538.1|1058397_1058547_+|hypothetical-protein
MALNLITFASEAEAHSGGPNPWVIGGLVLLLLLGLLAGVVAIGGGREHS
>NZ_CP049867.1|WP_166084537.1|1057748_1058387_+|CDP-alcohol-phosphatidyltransferase-family-protein
MDTRADPATLDIWTDVAGERIGTSATVVTGVRTVAAVVLAGLAAHQESLELLVACLVVYWVGDSLDGYVARLRGCETRIGASLDILSDRFCAAAFYIGLMWLEPGYAPAILIYLAEFMVVDCFLSLAFLAWPIRSPNYFFAIDRQLWLWNWSKPGKAVNSSLFAVLLLVTGWVAVGVVIATALLVLKVVSLVRLSQIGLPVPARPEPVGRAG
>NZ_CP049867.1|WP_166084536.1|1056439_1057765_+|glutamate-5-semialdehyde-dehydrogenase
MAAPPAPPAPPGSPDPAPDRPLLDTHAAVLEAARRARAASHPLAVTSRAAKDAALLAMADALVAHTDEVLAANAEDVLAAEQRGTPAAMVDRLRLDVARVAGMATGLREVAALPDPVGEVLRGSTLANGLELRQVRVPFGVVGIIYEARPNVTADAAGICLKSGNAVLLRGSSSARRSNEAIVAVLRDAAAGAGLPADAVQLVPGEGHDAAKVLMQARGLVDVLIPRGGAGLIRSVVTESQVPVIETGVGNCHVYVDAAADLDMALAIVLNAKTHRPSVCNAAESLLVHADVAAEFLPRVLAALADAGVTVHGDERVAAQAGDGSVVPATEEDWETEYLSLDLSAAVVDSLDDAIAHIRRWSSGHTEAIVTGSLEASRRFTAEVDAAAVVVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLPEMTSSKYVVTGDGHTR
>NZ_CP049867.1|WP_166089705.1|1065307_1066375_-|YbdK-family-carboxylate-amine-ligase
MEEELFLVDPATGELTAVAQSAVESRAATSAETTIELELYQQQIELATAPEDDLDALRRRLVEARTAVVAAAGAAGASAVAMPVPVLSVPRHPDLTPDERYERIQTDYGRLARDAVACAMHLHVAVEDDEVVRVVDGVRPWLPSLLAISANSPFNRGEDTGHASWRSQVWSRWPSAGPRQEFGSSEEYDRTTRLLVEWGASLDEPMVYFDVRPGNGLPTVEIRVADVCTDVDDAILLAALGRALVTTAAAGRTSTEGWRADLLRAAQWRAAHDGLAGGLVDPTTWKLSPAATVLDALVEHVRDALEDTGDLDLVRELASRVLADGGGAERQRALVRDGATMPEVVADLARRTAAS
>NZ_CP049867.1|WP_166084544.1|1066483_1067077_+|hemerythrin-domain-containing-protein
MSDVPQDLPTWDEAARPRGAGYPDATPAERSQGEHLRMVHDMYRRSLAQVDDVLEQVRSGRLTVGEARGAVHALGVRVTFAQLGSFCGQLCQSVETHHRIEDAHLYPALRAADSALDPVLDRLDLEHRVIHDVLERFDRVLVALATTSADGDGPGEGESGLPDVYAHFEHLRGLLESHFRYEEEQIGTALGVHRVMV
>NZ_CP049867.1|WP_166084545.1|1067198_1068896_+|sodium:solute-symporter-family-protein
MILNASTELRLDTNWIDYLLIFLYFGFVLGIGILARRSVSSSIDFFLSGRSLPAWVTGLAFISANLGAVEIMGMSANGAQYGIATAHYFWVGAVPAMLFLGVVMMPFYYGSKVRSVPEFMLRRFGPGTHLVTGLSFALAQLLIAGINLFLLATIVEILLGWPLWVSLVIAAAIVLSYTALGGLSAAIYNEVLQFFVIVAALAPLTFVGLHKVGGWNGLTSEVENRWGAEEMSSWPGTTLTGIDSPLLSVIGIVFGLGFVLSFGYWTTNFVEVQRAMASSSMSAARRSPIIGAFPKMFMPFIVIVPGMVAAVAVSEVVQAKESGATFDYNNSLLYLMRDLLPNGMLGLALAGLLASFMAGMAANISAFNTVFSYDIWETYVVKDKPDHYYLSVGRLATVAATIVAIGTAFIASQYSNIMNYIQTLFGFFNAPLFATFILGLLWARMSPAAGWTAMVAGPGAAGVVGWLSEDTFGGLSIGVLPFAGQGASFVAAGAAFVASIVVGTVVTLMSRTFKSESELRGLVWKLTPKEDISHTDEPGARWYQKPVPLAGVGLATVIVLNLLFW
>NZ_CP049867.1|WP_166084546.1|1068906_1069239_+|hypothetical-protein
MSEHTSPTSGHDDGSTPEKAHKAGAFDVRNFIGALLGLYGLILLPTGLFATDDAALAKADGLNVNIWTGVALLIAGGVFIAWARLRPVVVPADPDDQPAGQGDDGQRPAH
>NZ_CP049867.1|WP_166084547.1|1069320_1070139_+|DUF1206-domain-containing-protein
MAATPSSSTSPDIDGSDVLDQGVRLGLVAYGLVHLVVAWTAIQLALGESSGKASQTGALQQLAEDSMGGASLYAVALGFAALVFWQAAEALIGHRSEDGGKRVFKRVGSGVKAVVYGALAVSSVKIASGNGGRSKGTDTVTAQVMSAPGGQLIVGAAGLVVVAVGCYLAYKGVTQKFTKRLDTEGTSGNRRTPVVVLGTVGYVAKGVALAAIGGLFVSAAVQHDAQESGGLDQALHALLQQPFGRPLLIAVALGLAAYGLFCFLWARHLKRD
>NZ_CP049867.1|WP_166084548.1|1070233_1070995_-|SDR-family-oxidoreductase
MSVLDLFRLDGKVAVVTGASSGLGVAFAEALAEAGADVALGARRVEKLDETRAKVEALGRRAIAVATDVSSPEDCQALVDAAVSELGRVDILVNNAGIGTAVPATRETPEQFRQVIDVNLNGCYWMAQACGRVMEPGSSIVNISSVLGLTTAGLPQAAYAASKAGLIGLTRDLAQQWTGRKGIRVNALAPGFFASEMTDQYPDGYLDAMGQRIPMGRKGEAAELAAALVFLAGDAGGYVTGQTIAVDGGMTIT
>NZ_CP049867.1|WP_166084549.1|1071057_1072062_-|UDP-glucose-4-epimerase-GalE
MKVLVTGGAGYIGSTTCKALEAAGHTPVVLDSLLTGPRVFVKDRIFYEGDIADRDLLSRVVEEHPDIESTIHMAARIVVPESVEQPYEYYRDNVAKSLTLFDQLTKLGKPRVLFSSSASLYATKDGFEVTEVDPLDPGSPYARTKRVMEMVLTDMAAATDLRAISLRYFNPIGSDPDLESGIYAREPSHVLGQLVMAAQGLKDAFTITGVEHPTRDGTGIRDYIHVWDLAEAHVRAVETFDEVLATVDAPSTIINVGTGDGVTVRELVASFERVFGEQVPVREAPPRPGDAVGAFANVDKAREVLGWTASLTIDDAIASALAWGRKRKEILGYE
>NZ_CP049867.1|WP_166084550.1|1072258_1074793_+|leucine--tRNA-ligase
MSDHQTSDPGTDRDERATYDVPGVQEKWLKAWEEHPFTAGQGGIHGDGEKRYALTMFPYPSGDLHMGHAEVMALHDVIARYWWQRGYDVLNPIGWDSFGLPAENAAIRNDENPAVYTYANIDTQAESFRRYAISFDWSRRLNTSDPEYYRWTQWLFLKFREQGLAYRKFSPVNWCPNDQTVLANEQVVQGMCERCGAEVTKRELSQWYFKVTDYAQRLLDDMVPLEGTWPSKVLAMQRNWIGRSEGAHVDFVVEGASTGSTTESTPIRVFTTRPDTLFGATFMVVAADAKLAAEIVAPERRQALDDYLVEVRKATDIDRLATDRPKTGVDLGVTAVNPVTGARIPVWASDYVLADYGTGAIMAVPGQDQRDWEFAATFDLPVIRTVQPTEGFEESGGEAFTGAGPAINSSNDEISLDGLGIDEAKTRIIDWLESKGTGTRFVNFRLRDWLLSRQRYWGAPIPIIHCETCGEVAVPEDQLPVELPDLRGSDLKPKGVSPLAAAEDWVNVDCPQCGGAAKRDSDTMDTFVDSSWYFLRYCSPQYTDGPFDPEAVREWMPAAQYVGGVEHAILHLLYSRFFTKVLHDLGMVDFTEPFTALLNQGQVINRGKAMSKSLGNGVNLGEMIDAYGVDAVRLTMVFAGPPEDDIDWADMSPGGSLKFLQRAWRLSGDVTAPVGASAAEGDTALRQVTHRTVREAEQLIESHRFNVLVARTMELVNVTRKAIDSGCGPADPAVREAAETVAVLLSLVAPYTAEEMWERLGHEPTVARAGWPVVEEALLVQESVTAVVQIQGKVKARLEVSPEISEADLEAAALADESVQRALDGKTVRKVIVRAPKLVNIVAT
>NZ_CP049867.1|WP_166084551.1|1075410_1076421_-|sugar-phosphate-isomerase/epimerase
MTTHPRPFTLFTGQWADLTLEEVAGLAAGWGYDGLEIAVSGEHLDAWRWDDEAYVAERLALLERHGLQLFAISNHLKGQAVCDDPIDERHRDLVGSRVWGDGDPEGVRQRAAEEMQHTARLAQKLGVKTVVGFTGSSIWPYVAMFPPVSAERIEAGFTDFADRWNPILDVFDECGVRFAHEVHPSEIAYDHWSTVRTLEAIGHRPGFGLNWDPSHMVWQDIDPVSFITDFADRIYHVDCKDTRMRVGNGRNGRLGSHLPWGDPRRGWDFVSAGRGDVPWEDCFRALSAIGYDGPISVEWEDAGMDRLHGAPEALAYLRRLDFPPATASFDAAFKQD
>NZ_CP049867.1|WP_166084552.1|1076431_1077622_-|Gfo/Idh/MocA-family-oxidoreductase
MTAAHPHERPLGVAVLGYSFMGKAHSNAWRNVRAFFPDVPPVRQAVLVGRDAAQVAAAGAAYGWDETATDWRQVIERPDVDLVDVCLPGHLHAEVAQAALAAGKHVLLEKPLANDVAEAEALVEAARSARAHGVRSMVGFNYRRVPALELARDLVAQGRIGTVRQVRICYLQDWLTDESAPMTWRLRREQAGSGVIGDLASHAVDQLGFLTGDSVASVSATTRTFVPERTGPAGPEAVTVEDAAWATLQTHGGAVASLEVSRVAAGRKNGFQIEVYGSRGSVSFDLEHLNQLRVHDAPGGSTLTAGTTDVMVTEPGHPHLEAWWPTGHVLGWDHTFTNQAADLLRCLATGTDPRPSFEDGLAVQRVLAAMEQSAADGSRCVAVGADELAVSVPVTA

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Crispr_ID: NZ_CP049867_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_8

1065154-1065288

Orphan

Consensus_repeat	Method
GATCTCGACGACGGGCGCGGGGCGCCCTGCTCGATCACCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_8

>merge|NZ_CP049867|8|1065154-1065288|CRISPRCasFinder
GATCTCGACGACGGGCGCGGGGCGCCCTGCTCGATCACCGGGGGACCGATCTCGACGACGGGAGCGGGGCGCCCTGCTCGATCACCGGGGGGCCGATCTCGACGACGGGCGCGGGGCGCCCTGCTCGATCACCGG

>NZ_CP049867|8|8|1065154-1065288|CRISPRCasFinder
GATCTCGACGACGGGCGCGGGGCGCCCTGCTCGATCACCGG	GGGACCGATCTCGACGACGGGAGCGGGGCGCCCTGCTCGATCACCGGGGGGCC
GATCTCGACGACGGGCGCGGGGCGCCCTGCTCGATCACCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166084548.1\|1070233_1070995_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235500
NZ_CP049867.1\|WP_166084544.1\|1066483_1067077_+\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|213983
NZ_CP049867.1\|WP_166084545.1\|1067198_1068896_+\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271372
NZ_CP049867.1\|WP_166084552.1\|1076431_1077622_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP049867.1\|WP_166084542.1\|1062534_1063026_-\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|176867
NZ_CP049867.1\|WP_166084546.1\|1068906_1069239_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166083598.1\|1060922_1061201_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166084538.1\|1058397_1058547_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166084540.1\|1059688_1060336_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP049867.1\|WP_166084541.1\|1061159_1062302_+\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NZ_CP049867.1\|WP_166084550.1\|1072258_1074793_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP049867.1\|WP_166084547.1\|1069320_1070139_+\|DUF1206-domain-containing-protein	unknown	unknown	gnl\|CDD\|377695
NZ_CP049867.1\|WP_166084549.1\|1071057_1072062_-\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|187558
NZ_CP049867.1\|WP_166089705.1\|1065307_1066375_-\|YbdK-family-carboxylate-amine-ligase	unknown	unknown	gnl\|CDD\|237408
NZ_CP049867.1\|WP_166084536.1\|1056439_1057765_+\|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|234685
NZ_CP049867.1\|WP_166084539.1\|1059290_1059674_+\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|376779
NZ_CP049867.1\|WP_166084543.1\|1063136_1064408_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP049867.1\|WP_166089703.1\|1058634_1059294_+\|nicotinate-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
NZ_CP049867.1\|WP_166084551.1\|1075410_1076421_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NZ_CP049867.1\|WP_166084537.1\|1057748_1058387_+\|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|376450

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166084548.1\|1070233_1070995_-\|SDR-family-oxidoreductase	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	8.13192e-86
NZ_CP049867.1\|WP_166084544.1\|1066483_1067077_+\|hemerythrin-domain-containing-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	6.97574e-11
NZ_CP049867.1\|WP_166084545.1\|1067198_1068896_+\|sodium:solute-symporter-family-protein	gnl\|CDD\|271372	cd11478, SLC5sbd_u2, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NZ_CP049867.1\|WP_166084552.1\|1076431_1077622_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.49829e-66
NZ_CP049867.1\|WP_166084542.1\|1062534_1063026_-\|polyketide-cyclase	gnl\|CDD\|176867	cd07825, SRPBCC_7, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	3.27602e-39
NZ_CP049867.1\|WP_166084540.1\|1059688_1060336_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.14959e-52
NZ_CP049867.1\|WP_166084541.1\|1061159_1062302_+\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	6.50817e-102
NZ_CP049867.1\|WP_166084550.1\|1072258_1074793_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP049867.1\|WP_166084547.1\|1069320_1070139_+\|DUF1206-domain-containing-protein	gnl\|CDD\|377695	pfam06724, DUF1206, Domain of Unknown Function (DUF1206). This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.	9.60256e-15
NZ_CP049867.1\|WP_166084549.1\|1071057_1072062_-\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.10846e-120
NZ_CP049867.1\|WP_166089705.1\|1065307_1066375_-\|YbdK-family-carboxylate-amine-ligase	gnl\|CDD\|237408	PRK13517, PRK13517, glutamate--cysteine ligase.	9.4639e-102
NZ_CP049867.1\|WP_166084536.1\|1056439_1057765_+\|glutamate-5-semialdehyde-dehydrogenase	gnl\|CDD\|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	0
NZ_CP049867.1\|WP_166084539.1\|1059290_1059674_+\|ribosome-silencing-factor	gnl\|CDD\|376779	pfam02410, RsfS, Ribosomal silencing factor during starvation. This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.	6.79456e-45
NZ_CP049867.1\|WP_166084543.1\|1063136_1064408_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	8.55071e-13
NZ_CP049867.1\|WP_166089703.1\|1058634_1059294_+\|nicotinate-nucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	1.10461e-92
NZ_CP049867.1\|WP_166084551.1\|1075410_1076421_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	7.5574e-32
NZ_CP049867.1\|WP_166084537.1\|1057748_1058387_+\|CDP-alcohol-phosphatidyltransferase-family-protein	gnl\|CDD\|376450	pfam01066, CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.	1.32525e-06

>NZ_CP049867.1|WP_166084543.1|1063136_1064408_+|alpha/beta-hydrolase
MTEHPTAGQRREVAGVVVTDHWLDLPLDHADPTGPTIEVFGREVAAPGGFDRPLLVFLQGGPGHEAPRPTGFPAAPAWLERALQDHRVLMLDQRGTGLSTPYGDPDPDPAADANRLRHFRADAIVRDAEAFREHLGERKVSLLGQSFGGFCTLHYLSSAPDSVRAAIFTGGLPVVGRPVDDVYAATFTQMRRLNELHHRRYPMDRDRLARLLALCDAGEVLDPEGRPLSRRMVRTIGNRLGFDGGSEELHYLLERDPHSAAFRHDVVGLFPFGARNPMYAVIHESSYADGVITGWSAARVQPDDFAAADSLLLTGEHLFPWHFEEDPALRPYAEVAGLLADEAWPKLFDAGVLADLDVPAAAVVYAEDPFVDRGLSLQTAALVPSLRTWVTDQYLHGGLRHGGGDLLDRLLGMTKAAVAVRGD
>NZ_CP049867.1|WP_166084542.1|1062534_1063026_-|polyketide-cyclase
MSECLETSRLIPAPASEIFALLCDPQGHVAIDASGMLQDATGEPVTAVGDSFVVHMDREALGDLPDWGRYDVTVRIEELEPDQLITWSILGRIRPQIGHRYGYRLEPAEEGTRVTSIYDWSEARQDFKDNGVFPVISEANLRATLGILDRTVRRGYPAADART
>NZ_CP049867.1|WP_166084541.1|1061159_1062302_+|uracil-DNA-glycosylase
MLFYACPDVVETSHVSILGQAPRNRHIAVGGPRHDRGTADRGRHCDQCEHSEEARERAPARRGFKPGGAPRFQKQAARRLDRRLPRPRPPQRDADRGRTGRDGRWRGAHHRLDARCGGSSDGIVGAQPVRIGGRRVGSRRREALLADVDPEEAAGLAALARTRRPWPGVLDDELEKPYFRDLMGMVDRGRRTGVVYPPAGDLFAAFHLTPYDKVKVVILGQDPYHQPGQANGLCFSVPRDVPRLPPSLRNIYAMMTRDGLTPPPHGDLTEWAQRGVLLLNTALTVRDSRANSHAKQWRQFADAAITKLSDRDRPVVFVLWGKAAQRKRDLIDEDRHAVVTAPHPAARGRSQTEFREAKTLTEVNRRLDTLGVTPVDWAIT
>NZ_CP049867.1|WP_166083598.1|1060922_1061201_-|hypothetical-protein
MASFDDVWTRIEQHAGQQFITATGLPFTYRVPGDYLKVSRDGREINRSLSRTNFMKAAAAMPTSKPSDIKDRQGSAYTWAILMDPRVRAGAW
>NZ_CP049867.1|WP_166084540.1|1059688_1060336_+|histidine-phosphatase-family-protein
MSQQPSKRLFLLRHGRTEWNHTRRAQGQANVPLDEVGHAQAQAAAPRLALVGAVRLWSSDLARARQTADHVAAATGLTVEEDPRLREFSVGEREGMTWDEAVAEFPQMADGISLGERLKGVPGAEDNDDVRARIVPAVEDCFAALSWGETGIAVSHGAALKLALGGLLGWDEHAVNSLGVLDNCHWATVLEPGEGRARRLLAYGVGDFASATTIG
>NZ_CP049867.1|WP_166084539.1|1059290_1059674_+|ribosome-silencing-factor
MTATDHALELVRAAAQAASDKLAEDVIAFDVSDQLVITDAFVLASASNDRQVKAIVEAVEDSLRELGAKPVRREGERDGRWVLMDYAEIVVHVQHEEERAFYALERLWRDCPLIELPESVTSTRRSS
>NZ_CP049867.1|WP_166089703.1|1058634_1059294_+|nicotinate-nucleotide-adenylyltransferase
MGGTFDPIHHGHLVAASEVQAWYDLDEVVFVPTGQPYQKAERSVSPAEHRYLMTVIATASNPRFTVSRVDIDRDGPTYTVDTLSDLAAVFPDADLYFITGADALQDILGWRAADDLFELAHFVGCTRPGYAMDHGTLAGMPHDRVTIVEIPALAISSTDCRARTARGEPVWYLVPDGVVQYITKHRLYLSDRPSAPEALGPSPEPDPEPTDRTTPQGVS
>NZ_CP049867.1|WP_166084538.1|1058397_1058547_+|hypothetical-protein
MALNLITFASEAEAHSGGPNPWVIGGLVLLLLLGLLAGVVAIGGGREHS
>NZ_CP049867.1|WP_166084537.1|1057748_1058387_+|CDP-alcohol-phosphatidyltransferase-family-protein
MDTRADPATLDIWTDVAGERIGTSATVVTGVRTVAAVVLAGLAAHQESLELLVACLVVYWVGDSLDGYVARLRGCETRIGASLDILSDRFCAAAFYIGLMWLEPGYAPAILIYLAEFMVVDCFLSLAFLAWPIRSPNYFFAIDRQLWLWNWSKPGKAVNSSLFAVLLLVTGWVAVGVVIATALLVLKVVSLVRLSQIGLPVPARPEPVGRAG
>NZ_CP049867.1|WP_166084536.1|1056439_1057765_+|glutamate-5-semialdehyde-dehydrogenase
MAAPPAPPAPPGSPDPAPDRPLLDTHAAVLEAARRARAASHPLAVTSRAAKDAALLAMADALVAHTDEVLAANAEDVLAAEQRGTPAAMVDRLRLDVARVAGMATGLREVAALPDPVGEVLRGSTLANGLELRQVRVPFGVVGIIYEARPNVTADAAGICLKSGNAVLLRGSSSARRSNEAIVAVLRDAAAGAGLPADAVQLVPGEGHDAAKVLMQARGLVDVLIPRGGAGLIRSVVTESQVPVIETGVGNCHVYVDAAADLDMALAIVLNAKTHRPSVCNAAESLLVHADVAAEFLPRVLAALADAGVTVHGDERVAAQAGDGSVVPATEEDWETEYLSLDLSAAVVDSLDDAIAHIRRWSSGHTEAIVTGSLEASRRFTAEVDAAAVVVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLPEMTSSKYVVTGDGHTR
>NZ_CP049867.1|WP_166089705.1|1065307_1066375_-|YbdK-family-carboxylate-amine-ligase
MEEELFLVDPATGELTAVAQSAVESRAATSAETTIELELYQQQIELATAPEDDLDALRRRLVEARTAVVAAAGAAGASAVAMPVPVLSVPRHPDLTPDERYERIQTDYGRLARDAVACAMHLHVAVEDDEVVRVVDGVRPWLPSLLAISANSPFNRGEDTGHASWRSQVWSRWPSAGPRQEFGSSEEYDRTTRLLVEWGASLDEPMVYFDVRPGNGLPTVEIRVADVCTDVDDAILLAALGRALVTTAAAGRTSTEGWRADLLRAAQWRAAHDGLAGGLVDPTTWKLSPAATVLDALVEHVRDALEDTGDLDLVRELASRVLADGGGAERQRALVRDGATMPEVVADLARRTAAS
>NZ_CP049867.1|WP_166084544.1|1066483_1067077_+|hemerythrin-domain-containing-protein
MSDVPQDLPTWDEAARPRGAGYPDATPAERSQGEHLRMVHDMYRRSLAQVDDVLEQVRSGRLTVGEARGAVHALGVRVTFAQLGSFCGQLCQSVETHHRIEDAHLYPALRAADSALDPVLDRLDLEHRVIHDVLERFDRVLVALATTSADGDGPGEGESGLPDVYAHFEHLRGLLESHFRYEEEQIGTALGVHRVMV
>NZ_CP049867.1|WP_166084545.1|1067198_1068896_+|sodium:solute-symporter-family-protein
MILNASTELRLDTNWIDYLLIFLYFGFVLGIGILARRSVSSSIDFFLSGRSLPAWVTGLAFISANLGAVEIMGMSANGAQYGIATAHYFWVGAVPAMLFLGVVMMPFYYGSKVRSVPEFMLRRFGPGTHLVTGLSFALAQLLIAGINLFLLATIVEILLGWPLWVSLVIAAAIVLSYTALGGLSAAIYNEVLQFFVIVAALAPLTFVGLHKVGGWNGLTSEVENRWGAEEMSSWPGTTLTGIDSPLLSVIGIVFGLGFVLSFGYWTTNFVEVQRAMASSSMSAARRSPIIGAFPKMFMPFIVIVPGMVAAVAVSEVVQAKESGATFDYNNSLLYLMRDLLPNGMLGLALAGLLASFMAGMAANISAFNTVFSYDIWETYVVKDKPDHYYLSVGRLATVAATIVAIGTAFIASQYSNIMNYIQTLFGFFNAPLFATFILGLLWARMSPAAGWTAMVAGPGAAGVVGWLSEDTFGGLSIGVLPFAGQGASFVAAGAAFVASIVVGTVVTLMSRTFKSESELRGLVWKLTPKEDISHTDEPGARWYQKPVPLAGVGLATVIVLNLLFW
>NZ_CP049867.1|WP_166084546.1|1068906_1069239_+|hypothetical-protein
MSEHTSPTSGHDDGSTPEKAHKAGAFDVRNFIGALLGLYGLILLPTGLFATDDAALAKADGLNVNIWTGVALLIAGGVFIAWARLRPVVVPADPDDQPAGQGDDGQRPAH
>NZ_CP049867.1|WP_166084547.1|1069320_1070139_+|DUF1206-domain-containing-protein
MAATPSSSTSPDIDGSDVLDQGVRLGLVAYGLVHLVVAWTAIQLALGESSGKASQTGALQQLAEDSMGGASLYAVALGFAALVFWQAAEALIGHRSEDGGKRVFKRVGSGVKAVVYGALAVSSVKIASGNGGRSKGTDTVTAQVMSAPGGQLIVGAAGLVVVAVGCYLAYKGVTQKFTKRLDTEGTSGNRRTPVVVLGTVGYVAKGVALAAIGGLFVSAAVQHDAQESGGLDQALHALLQQPFGRPLLIAVALGLAAYGLFCFLWARHLKRD
>NZ_CP049867.1|WP_166084548.1|1070233_1070995_-|SDR-family-oxidoreductase
MSVLDLFRLDGKVAVVTGASSGLGVAFAEALAEAGADVALGARRVEKLDETRAKVEALGRRAIAVATDVSSPEDCQALVDAAVSELGRVDILVNNAGIGTAVPATRETPEQFRQVIDVNLNGCYWMAQACGRVMEPGSSIVNISSVLGLTTAGLPQAAYAASKAGLIGLTRDLAQQWTGRKGIRVNALAPGFFASEMTDQYPDGYLDAMGQRIPMGRKGEAAELAAALVFLAGDAGGYVTGQTIAVDGGMTIT
>NZ_CP049867.1|WP_166084549.1|1071057_1072062_-|UDP-glucose-4-epimerase-GalE
MKVLVTGGAGYIGSTTCKALEAAGHTPVVLDSLLTGPRVFVKDRIFYEGDIADRDLLSRVVEEHPDIESTIHMAARIVVPESVEQPYEYYRDNVAKSLTLFDQLTKLGKPRVLFSSSASLYATKDGFEVTEVDPLDPGSPYARTKRVMEMVLTDMAAATDLRAISLRYFNPIGSDPDLESGIYAREPSHVLGQLVMAAQGLKDAFTITGVEHPTRDGTGIRDYIHVWDLAEAHVRAVETFDEVLATVDAPSTIINVGTGDGVTVRELVASFERVFGEQVPVREAPPRPGDAVGAFANVDKAREVLGWTASLTIDDAIASALAWGRKRKEILGYE
>NZ_CP049867.1|WP_166084550.1|1072258_1074793_+|leucine--tRNA-ligase
MSDHQTSDPGTDRDERATYDVPGVQEKWLKAWEEHPFTAGQGGIHGDGEKRYALTMFPYPSGDLHMGHAEVMALHDVIARYWWQRGYDVLNPIGWDSFGLPAENAAIRNDENPAVYTYANIDTQAESFRRYAISFDWSRRLNTSDPEYYRWTQWLFLKFREQGLAYRKFSPVNWCPNDQTVLANEQVVQGMCERCGAEVTKRELSQWYFKVTDYAQRLLDDMVPLEGTWPSKVLAMQRNWIGRSEGAHVDFVVEGASTGSTTESTPIRVFTTRPDTLFGATFMVVAADAKLAAEIVAPERRQALDDYLVEVRKATDIDRLATDRPKTGVDLGVTAVNPVTGARIPVWASDYVLADYGTGAIMAVPGQDQRDWEFAATFDLPVIRTVQPTEGFEESGGEAFTGAGPAINSSNDEISLDGLGIDEAKTRIIDWLESKGTGTRFVNFRLRDWLLSRQRYWGAPIPIIHCETCGEVAVPEDQLPVELPDLRGSDLKPKGVSPLAAAEDWVNVDCPQCGGAAKRDSDTMDTFVDSSWYFLRYCSPQYTDGPFDPEAVREWMPAAQYVGGVEHAILHLLYSRFFTKVLHDLGMVDFTEPFTALLNQGQVINRGKAMSKSLGNGVNLGEMIDAYGVDAVRLTMVFAGPPEDDIDWADMSPGGSLKFLQRAWRLSGDVTAPVGASAAEGDTALRQVTHRTVREAEQLIESHRFNVLVARTMELVNVTRKAIDSGCGPADPAVREAAETVAVLLSLVAPYTAEEMWERLGHEPTVARAGWPVVEEALLVQESVTAVVQIQGKVKARLEVSPEISEADLEAAALADESVQRALDGKTVRKVIVRAPKLVNIVAT
>NZ_CP049867.1|WP_166084551.1|1075410_1076421_-|sugar-phosphate-isomerase/epimerase
MTTHPRPFTLFTGQWADLTLEEVAGLAAGWGYDGLEIAVSGEHLDAWRWDDEAYVAERLALLERHGLQLFAISNHLKGQAVCDDPIDERHRDLVGSRVWGDGDPEGVRQRAAEEMQHTARLAQKLGVKTVVGFTGSSIWPYVAMFPPVSAERIEAGFTDFADRWNPILDVFDECGVRFAHEVHPSEIAYDHWSTVRTLEAIGHRPGFGLNWDPSHMVWQDIDPVSFITDFADRIYHVDCKDTRMRVGNGRNGRLGSHLPWGDPRRGWDFVSAGRGDVPWEDCFRALSAIGYDGPISVEWEDAGMDRLHGAPEALAYLRRLDFPPATASFDAAFKQD
>NZ_CP049867.1|WP_166084552.1|1076431_1077622_-|Gfo/Idh/MocA-family-oxidoreductase
MTAAHPHERPLGVAVLGYSFMGKAHSNAWRNVRAFFPDVPPVRQAVLVGRDAAQVAAAGAAYGWDETATDWRQVIERPDVDLVDVCLPGHLHAEVAQAALAAGKHVLLEKPLANDVAEAEALVEAARSARAHGVRSMVGFNYRRVPALELARDLVAQGRIGTVRQVRICYLQDWLTDESAPMTWRLRREQAGSGVIGDLASHAVDQLGFLTGDSVASVSATTRTFVPERTGPAGPEAVTVEDAAWATLQTHGGAVASLEVSRVAAGRKNGFQIEVYGSRGSVSFDLEHLNQLRVHDAPGGSTLTAGTTDVMVTEPGHPHLEAWWPTGHVLGWDHTFTNQAADLLRCLATGTDPRPSFEDGLAVQRVLAAMEQSAADGSRCVAVGADELAVSVPVTA

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Crispr_ID: NZ_CP049867_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_9

1174523-1174627

Orphan

Consensus_repeat	Method
GGTCGTCGCCGTCGCCACCGTCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_9

>merge|NZ_CP049867|9|1174523-1174627|CRISPRCasFinder
GGTCGACGGCCTCGCCGCCCTCGACGAGGTCGTCGCCGTCGCCACCGTCGGCGACGTCGGAGCCGCCCCGACCCTCGAGGCGGTCGTCGCCGTCGCCACCGCGGA

>NZ_CP049867|9|9|1174523-1174627|CRISPRCasFinder
GGTCGACGGCCTCGCCGCCCTCGA	CGAGGTCGTCGCCGTCGCCACCGTCGGCGACGTCGGAGCCGCCCCGACCCTCGAGGC
GGTCGTCGCCGTCGCCACCGCGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166084632.1\|1186393_1187473_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|340411
NZ_CP049867.1\|WP_166084630.1\|1183354_1185016_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP049867.1\|WP_166084623.1\|1165908_1167393_-\|NADP-dependent-phosphogluconate-dehydrogenase	unknown	unknown	gnl\|CDD\|236453
NZ_CP049867.1\|WP_166084635.1\|1188271_1189138_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912
NZ_CP049867.1\|WP_166084618.1\|1161055_1161814_-\|PIG-L-family-deacetylase	unknown	unknown	gnl\|CDD\|225031
NZ_CP049867.1\|WP_166084631.1\|1185012_1186404_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP049867.1\|WP_166084622.1\|1165382_1165814_+\|Hsp20-family-protein	unknown	unknown	gnl\|CDD\|365807
NZ_CP049867.1\|WP_166084629.1\|1182621_1183188_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166084620.1\|1163527_1164829_+\|DUF1501-domain-containing-protein	unknown	unknown	gnl\|CDD\|226587
NZ_CP049867.1\|WP_166084619.1\|1162086_1163517_+\|DUF1800-domain-containing-protein	unknown	unknown	gnl\|CDD\|378055
NZ_CP049867.1\|WP_166084637.1\|1189209_1189461_+\|DUF3099-domain-containing-protein	unknown	unknown	gnl\|CDD\|378630
NZ_CP049867.1\|WP_166084633.1\|1187460_1187880_-\|anti-sigma-regulatory-factor	unknown	unknown	gnl\|CDD\|340411
NZ_CP049867.1\|WP_166084616.1\|1157379_1160292_+\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NZ_CP049867.1\|WP_166084624.1\|1167604_1169035_+\|magnesium-chelatase	unknown	unknown	gnl\|CDD\|224160
NZ_CP049867.1\|WP_166084626.1\|1169031_1170996_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227204
NZ_CP049867.1\|WP_166084634.1\|1187876_1188272_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912
NZ_CP049867.1\|WP_166084621.1\|1164982_1165273_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133394
NZ_CP049867.1\|WP_166084617.1\|1160291_1160807_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166084639.1\|1192152_1193196_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NZ_CP049867.1\|WP_166084638.1\|1189659_1192116_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166084621.1\|1164982_1165273_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133394	cd04766, HTH_HspR, Helix-Turn-Helix DNA binding domain of the HspR transcription regulator. Helix-turn-helix (HTH) transcription regulator HspR, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	1.9626e-26
NZ_CP049867.1\|WP_166084633.1\|1187460_1187880_-\|anti-sigma-regulatory-factor	gnl\|CDD\|340411	cd16934, HATPase_RsbT-like, Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains. This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.	2.22415e-36
NZ_CP049867.1\|WP_166084623.1\|1165908_1167393_-\|NADP-dependent-phosphogluconate-dehydrogenase	gnl\|CDD\|236453	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase.	0
NZ_CP049867.1\|WP_166084618.1\|1161055_1161814_-\|PIG-L-family-deacetylase	gnl\|CDD\|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	1.99007e-35
NZ_CP049867.1\|WP_166084631.1\|1185012_1186404_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.33586e-50
NZ_CP049867.1\|WP_166084622.1\|1165382_1165814_+\|Hsp20-family-protein	gnl\|CDD\|365807	pfam00011, HSP20, Hsp20/alpha crystallin family. Not only do small heat-shock-proteins occur in eukaryotes and prokaryotes but they have also now been shown to occur in cyanobacterial phages as well as their bacterial hosts.	6.9571e-27
NZ_CP049867.1\|WP_166084635.1\|1188271_1189138_-\|STAS-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	3.99183e-44
NZ_CP049867.1\|WP_166084620.1\|1163527_1164829_+\|DUF1501-domain-containing-protein	gnl\|CDD\|226587	COG4102, COG4102, Uncharacterized protein conserved in bacteria [Function unknown].	3.75366e-42
NZ_CP049867.1\|WP_166084619.1\|1162086_1163517_+\|DUF1800-domain-containing-protein	gnl\|CDD\|378055	pfam08811, DUF1800, Protein of unknown function (DUF1800). This is a family of large bacterial proteins of unknown function.	2.32393e-120
NZ_CP049867.1\|WP_166084637.1\|1189209_1189461_+\|DUF3099-domain-containing-protein	gnl\|CDD\|378630	pfam11298, DUF3099, Protein of unknown function (DUF3099). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	0.00235005
NZ_CP049867.1\|WP_166084616.1\|1157379_1160292_+\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	2.78734e-172
NZ_CP049867.1\|WP_166084624.1\|1167604_1169035_+\|magnesium-chelatase	gnl\|CDD\|224160	COG1239, ChlI, Mg-chelatase subunit ChlI [Coenzyme metabolism].	1.85338e-84
NZ_CP049867.1\|WP_166084626.1\|1169031_1170996_+\|hypothetical-protein	gnl\|CDD\|227204	COG4867, COG4867, Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only].	0
NZ_CP049867.1\|WP_166084634.1\|1187876_1188272_-\|STAS-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	4.43644e-29
NZ_CP049867.1\|WP_166084630.1\|1183354_1185016_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	2.12366e-38
NZ_CP049867.1\|WP_166084632.1\|1186393_1187473_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|340411	cd16934, HATPase_RsbT-like, Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains. This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.	3.25582e-28
NZ_CP049867.1\|WP_166084639.1\|1192152_1193196_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	1.64815e-134

>NZ_CP049867.1|WP_166084626.1|1169031_1170996_+|hypothetical-protein
MSDPRFRYGPWHGGPDPLAPPYDVRRALDEIGQDVLAGGSLREALRDLMRRGVDGRRGLDELRQRARRMRKAAQRRGDLAGTLDQVRAALDQALAAERETLAGADDADARLAEMDLATLPDDTAGAVRALDPYDWRSPEARATYEAIKEMLQREVLDAQFAGMKRFLEDGDPEAMQAVKDMMADLNDLLAAHARGEDTTDRFADFMDKHGEMFPENPENVDELIDALARRQAAADRMMASLRPEQREQLGQLMSQAMSDPDLASQMAQLSDNLRALRPGLERGPAQMGGGEPMGYSAAVEAIADLADLEALEQQLSEAGGPGSLDAVDVDTLEKQLGGEAAADMRALRELERELERQGFLTSGDDGLRLTPRAVRRLGETALKKVFDQIAASGSGDHDDRRTGSADEPTGLTRPWEFGDDLPLDAVRTVSNAVRRGGLVRTGSTDGGARLLVEDFEVVETEKRTSAAVALLVDLSFSMVNEGRWGPMKQTALALSHLVQTRFRQDALEIIGFNLTARRMTAVQLAEAEPEWVQGTNLQHALMLAGRHLRRHPDAEPVVMVVTDGEPTAHLWPDGTPEFRWPTTRETLRATVTQVDEITRWGASLNLFMLGEDPGLARFVDAIARRSGGRVFTPDIGRLGEYVVADYLRARRGRR
>NZ_CP049867.1|WP_166084624.1|1167604_1169035_+|magnesium-chelatase
MTDSPAAQTTSSTAPPAGTTRGALLAQGYRSRTVKEELRENLLSRLRAGAPAFPGIVGFDDTVLPQLEGALLAGHDLVLLGERGQGKTRLMRTLGTLLDEWMPVVEGCEINDDPAAPVCSRCRRLAAETGDDLPVVWVHRDDRYVEKLATPDTSVGDLVGDVDPVKVAEGRTLGDPETVHYGLIPRTNRGIFGINELPDLAERIQVAMFNVLEERDIQVRGYSLRLPLDLLLVASANPEDYTNRGRIITPLKDRFGAEIRTHYPVEVEEEVAVIAQEAELVAPVPAHLLEVLARLTRGLRESSSVDQRAGVSARFAIAAAEGVAASALRRAARTGDTHAVARVCDVPAVLPTLLGKLEFEMGEEGREVEVVRHLLRIAVAETFRERLLGLDLSGFTELFAEGAVVETGELVTTEELLSQLGPVSGLAKVLDRLGDDSDVAVDLGHVAAGVEFVLEGLHLTRRVDKENVGGRTVYGA
>NZ_CP049867.1|WP_166084623.1|1165908_1167393_-|NADP-dependent-phosphogluconate-dehydrogenase
MSDDTTGTADTTDSAARATIGVTGLAVMGRNLARNIARHGHVTAVHNRSVEKMQSLVDEFGDEGDFVACESLEDFVAAIEKPRAIIVMVKAGEATDAVIDDLVPLLDEDDIIVDAGNAHFDDTRRREEALAEKKLHFVGCGVSGGEEGALNGPSIMPGGSEHAYERLGPIFEDIAAEVDGSPCCTHVGPDAAGHFVKMVHNGIEYADMQLIAEAYDLLRRRLEMTPKDIAGVFEEWNGGDLESFLIEMTADVLAQDDPGTDTPFVDVVLDQAEQKGTGRWTVQSALDLGVPVTGIAEATFARSLSGHAGQRKAAREAFADVSVSSDAVDDRDAYVDDVRKALYASKVVAYAQGFDQIAAGSREHDWDVDPGGIARIWRGGCIIRARFLDRITEAYAEDAGLVSLLVNPYFAGVVSDGVQAWRRIVADAALHGIPTPAFASSLSFFDGLRAERLPAALIQGLRDNFGAHTYQRVDREGTYHLLWAGDRTEERQDD
>NZ_CP049867.1|WP_166084622.1|1165382_1165814_+|Hsp20-family-protein
MLMRTDPFRDLDRLAQQVFGAGTTSRPAVMPMDAWREGDTFVLEFDLPGVSRESIDIDVERNVLTIRAERPRRNGDWEMLASERPTGHFSRQLVLGDNLDLERIDASYDAGVLLLRVPVAEKAKPRKVEISVGSSEQKKSIDA
>NZ_CP049867.1|WP_166084621.1|1164982_1165273_-|MerR-family-transcriptional-regulator
MTQRARQRPGHHAVYAISVAADIVGTNVQNLRVYERRGLLEPHRTDGGTRLYSQDDLDRLVRIVELLEAGVNLAGIALVLDLEAENTRLRRRLERA
>NZ_CP049867.1|WP_166084620.1|1163527_1164829_+|DUF1501-domain-containing-protein
MTTDSTGCGCPDFTRTTLSRRRFLAGAAAGAGALTTGSLFGDAHRQVAYGAAPGGNVVVVLSLRGGCDGLSIVVPRGVTDHDRLRALRPRIVVPRESLLGADPAFGLHPAFAPLASMWDDGRFGAVHAVGLPAPNRSHFDAMQTIEDADPGTSERVGWINRTIGLDATAVEETAVQLGSSLLPTSLVGPAGAIGAARVNDLGLYDLGAGRTARQASLQEMWGNQAGLLGRSMRGTLATVKRLEPAVAAADDDAPGGSSVHESAFPEGPLRSVLANTSALIRADVGTRVVTVDYGNWDMHNGLGGADPTRGWMADQVRHLAGSLAAFFTDLGPAASRVTVVTLSEFGRRVKENGDNGVDHGYGNVMLLLGAGVKGGTVHGSWPGLADLDDGDLRVTRDYRSVLWEVLSTRFPDVSGSRATIFPSLTPETIGAMA
>NZ_CP049867.1|WP_166084619.1|1162086_1163517_+|DUF1800-domain-containing-protein
MPQLSAADLHLVRRFSGGLSRGLATDVRRAGGGRAWLVGQLSPASVADAPGDDIDTWFPSLSHAPKQIFERQRSDVQGSWEVMWDLSRWTVARRIQSRRQVREVMVDFWSNLLHVPLGDDVAAFWRVDYDRVLREHALGSFEDLLRAAITHPAMGLSLDNAVSTKDNPNENLGRELLELHTVGHGSGYTEADVKASSRMLTGYRADVWWPEFRSFYDPSVHATGRIDVLGFSHPNTDADGRAATDAYLRYLARHPATAKRIARRLAVRFVSDRPSAALVDAVAAAYLKNGTAVRPTLLALVDHPDFAASAGTKVRLPTEDYVATVRAMRVVLQRPVDDESFVNAMYWQYVGFGQAPYEWPAPDGYPEVGEAWTSAGRLLGGMRHHVNLAAGWWPASQAQRPSAAAWLPPLPATLGAVIDHVGRQVLGQRPTASMRKAIATLLGMSLTRQVGRGDLWDMRVYAIIASLLDSPTHLHR
>NZ_CP049867.1|WP_166084618.1|1161055_1161814_-|PIG-L-family-deacetylase
MSEAPAPLRPLPEDWTTAVAIVAHPDDMEFGAAAAVARWTGQGKRIVYVMVTSGEAGIDGLAPDECRRVREAEQVESARVVGVEEVEFLGFPDGVVEYGLPLRAAVAHVVRRHRPEIVITGNFRDTFGPGALNQADHIAVGRAVLDGTRDAGNRWVFSDQLVDGLEPWGDTRAVWATGSPDARHGVDTTDTFDVGVASLQAHRAYIDGLGWADFDEREMLEGFGRMAGSRMGVAFAAPFEVYSLTWGGGDED
>NZ_CP049867.1|WP_166084617.1|1160291_1160807_+|hypothetical-protein
MAGLFSRGSSVPDPVRRAAGGKVLAWVQAEDGTWLAGTRDAWVQVPPEGEPLLLPWEQVHRADWDTEERSLTVERVEEWGSPTARWTHRLSEPGSLLVLLRERVTASIVLQRRVDVRRKKGFTVIARRPPGGEGSVTWAHQFDPGVDPADPAVAALAEAALVEAQESLGLR
>NZ_CP049867.1|WP_166084616.1|1157379_1160292_+|DNA-primase
MAGLIREEDIALVRERADLAEIIGQYVTLRSAGGGALKGLCPFHDEKSPSFHVRPGRGFHCLAAETRVITWEGVRPISELAGGTHRILGRDARWHDAPFRSYGTQQLWKITLTRNRQVKELFATDGHRWFVRSGKDQLSEREEVTTSLKAGDRLRSTFPTSRISQTTLSPFGVAHGFTFGDGTRAKRGSMALLCPPKDEVMLKWFPNSVTSASGPNLLVHHLPGFFKSTPSLEESAPYLLGWLAGYFAADGCVAADGTVMLNSARREHLEFVRALCTRLGIATFGITTQMREGFPGRAPSALHRVHFVNEDLPEEFFLIPEHRERFVRADKFARKGWVVRSVEETDRVEEVFCAEVEEGHAFVLEDNILTGNCFGCQEGGDVIAFLMKHDGLAFTQAVEYLADKTGVQLRYTEGDGTAPRRDPNKRNRLVEANRLAQDFYAGRLGQPDAVKARTFLDERGFDREAADTFGLGFAPRDGDALYKHLRQKQFTDGELVAAGLVAEGQRGHYDRFRGRLLWPIREVSGETIGFGARRIFDDDRIDAKYLNTPETAIYKKSQVLYGIDLARRDIARASQAVVVEGYTDVMACHLAGVPTAVATCGTAFGEDHGRVLRRLLHDHEEFRGEVIFTFDGDEAGQKAALRAFGGDQQFVGQTYVAVEPDGMDPCDLRLKSGDAAVRELVARRTPLYRFVLGNVVSRYDLDRADGRIDALREAAKLVSSVRDRSKVDAFARELAGMVGIEVEEARAEVRRASGRAERAAHDQRTAAGPMPGSRTGQGSGRGSGAGASQGGEHAAPVAPMPQMPNLRDPRFSLERETLKLVVQQPLLTARFSGDLADNDFTHPAYLAVWETVAALGGPGSAGDPDTWAATLRDSLVGQYSSAQHPIVSAFNGLVVEPLLAAGEPSPTYAAQHVFRLQELTAMRAIADLKSKLQRTNPVERAEEYNRMFGELVALESHRRTLRERAIGVDS
>NZ_CP049867.1|WP_166084629.1|1182621_1183188_-|hypothetical-protein
MSRRTTRSTALAAAATAAAGVLATPTPAVAEAVVYTSERASVRLTYGTDEPPSARESVRLDVPTGYVRDRRNPHKVTWHEPFTGGRAISVDLAPRNGTAADLRAQRDRTAATYGDSYRELAFDVDRSAGGMTARWAYSFTEPGTGDVDPFVSVVLTEGNRIEVVGRLAEREQVRAIRKHVVASARFVS
>NZ_CP049867.1|WP_166084630.1|1183354_1185016_-|SpoIIE-family-protein-phosphatase
MSPASTTLLVCDDTAAKRYVISSWLRRAGYEVIGASSAAEAMRTVATRSVDLVVLDVHLPDRSGLDVAMELKSTAETAAIPVVHISAVAMEPEHRSAGLDRGADAYLVDPIEPQELVSTVGALLRSSGARRRAESLATRLGRLNRAALRLNVATTVPRLSDAAAAGVQLVFGGRGAALVSSNDPAVPTQLMRRDDGLSPRHVVSVDPETLRSMLAAVPELGRVDLSDPTWSALAGDALATGNGPGGLVTQRAPETTPAGACAVAAIRSGSEVVGFVAVDSAMVSDHDDERMLAELAQAAGVAVENLRAMEAEHRTALILQRSLLPAILPPLDGLQLVARYRAADGQSQIGGDFFDAFVTDQGTAHVVIGDVQGHSLEAAVLMAELRYTLRAYAQDGHSPRDVLERLDLTLHRSRPDMTATLCLLAFGPPAPDGNRTVEVANAGHLPPLLVRDGTGDYLDASGPLLGGLLGAPETLTVDLRPGDRLVLITDGLVERRGEDLGANLDAFAAGVTASVLTAEALSDVLMAEHGRGHGPLDDDSALVLIDVVAPDAP
>NZ_CP049867.1|WP_166084631.1|1185012_1186404_-|HAMP-domain-containing-histidine-kinase
MGSDTLRHVVEVAEDLDVLRAREAARTVALALGSADVVATRVTVCVGSLAHDLAVAGGGRVELSATHGEPLRVRCTPRTATATSGRGPEPVSWAASAPAVALLADRTSLGDGADEATVALMVEDVVHALTADEVDVLRHRLAEPGHSTWADHLHDQGRDLMMVLAQLQSRDESPRERMEAESAADADGIIGLYHELSEELERTNQGVVALYAEIDDKSRQLREASEAKTRFMRNISHELRSPSNSIIGLARLLLDSGAESQLVDEQREQVNFIEASARDLLGLVDELLDLAAAESGRMDATAEAVDLAELFDELSGVTRPLLRSGVSLHVRPPEPGTTLHTDRTLLRHILRNLLSNAAKFTAEGRVDLSARTTAETVVLEVADTGIGIAEEDRSRVFEEFFQARSPLHAGVKGTGLGLAFAQRIAVTLGGSLELASTPGAGSRFSVRLPRKPSGTTAEGGGPA
>NZ_CP049867.1|WP_166084632.1|1186393_1187473_-|SpoIIE-family-protein-phosphatase
MGQMTSPGDLGSSSTDESVWIRVEEPSTCASVRRRAAELARQVQLAHDQIEEVAVAASELASNLVKHAREGAVLLRVLRRGGTAGVGVLTLDHGPGTRDIAALSVDGVTTTGTLGIGLGAVRRFADRLDLHSVPGLGTVVSAEFWRHESAARGGSDPTHGSDLFGGLLRPLPGESVCGDAYAHRATDDGSIVMMVDGLGHGPMAARASDAAVRTFLASRRSAPGHLLEELHVALRDTRGAAVAIARVDHRTQSLTYAGIGNIAGRVVDASASSQLASQPGIVGHNAPSVREVDVRLERGQWLVMHSDGLSDRWRVQDLPGVLATSPVVLSAALLRAAGGRRDDAGVLTLRLDGGGGHGQ
>NZ_CP049867.1|WP_166084633.1|1187460_1187880_-|anti-sigma-regulatory-factor
MTARLGERPTESHPVSDDADVVRVRQAVRTQAVAAKLSLIDQTKLVTATSELARNTVIYGRGGTAVIEHVSLHNRAGIRVTFSDGGPGIPDLEKALTDGWTSGVGMGLGLSGARRLVDEFDISSSPGEGTTVTVTKWAR
>NZ_CP049867.1|WP_166084634.1|1187876_1188272_-|STAS-domain-containing-protein
MTRIPILRIGDVLLVTIQVELEDHIATQLLEDLGEKLVATGARGVLIDISGLDIVDSFIGRMISMIASTSRVLDAQTVLVGMQPAVAITLVELGLTLPGVRTALDVDRGMDLLDRLLEHERRGRVLRARGR
>NZ_CP049867.1|WP_166084635.1|1188271_1189138_-|STAS-domain-containing-protein
MTTSASDPSWVELLRSNREAVLTRWADVAAATLAGRMTRSELERDCRDIFDGIIAAEDVAGGSGNGLTSDAYSDVRGLLAEISRTRARQGFTPTETAIGVFGLKEAVLSVLEASNDTEGYRGFAALSRRTDDLGLFMLETYAATREGVIAEQADTLMELSTPVVKLWDGVVALPLVGTLDSARTQVVMESLLQALVETGSEHAIIDITGVGAVDTQVAQHLLKTVQAARLLGAECIISGIRPQIAQTVVGLGIDFGDISTKSSLADALLLALRESGLDIVSRGGAQAD
>NZ_CP049867.1|WP_166084637.1|1189209_1189461_+|DUF3099-domain-containing-protein
MDRKRAYFWLMGCCVALIVLAWTVVKDVSLVAAAVMTVVAAVIPPVASAVANFGVLSGRRKLDFDEVPTWRRGGHEYGGHDDL
>NZ_CP049867.1|WP_166084638.1|1189659_1192116_+|hypothetical-protein
MPGRGRAALSTVLSAALISGVAAAAVVSTPTPAEAKVPNAGTTTTTLAATFRTQDQSLWGPGNAQGPGTQNLELFDESWNDSAEGGSYRDGAFGDEYGAGGSISTSGRVGMSLDLEGMDGGKVAVNYPVKVDVTTPAPKSFGAGDTIEISTSPAAVQSGAAITTVEPTLDAVTLKGTVGGRADASFEICVVDCGGESATLFHVPQTSGQIFRVSLEDLRSVSPGSPADTYCFGSAEKTALGLTEADRPTRCSGNGGYVARPNPVVSTTTNADGSLSASGTDTFALLPISAMKWVQRLVGDFPLNKSIDIGPLDLSWTTFDVSLNTSAQRTEELDFAAKVDVTLALPRSMSYRVVTPGGTQVSQGTGSSVTLRAGNKVLVDVPTDQTTAFSVTPSLSLAQPDLSNEVTHSVAFSGLMKVLQAALELDAEIFTIGFAVGPAYEYRFSAPSTDITAVPMRTWALAGFNAPTLAPVQIVPAPPPVVSPVTVTPVEGAPTDLTVATFTDEVTTAVPSDYAATISWGDGTPTVPATVTGKDGSYAISARHTYEQYGTYPVEVDLRTRPEGNLATNHVVTASSAVVSDAALTGTGLTNNTTASGQKVLIWANPSPAAPNNAVATFADANPFGLLSDLSATIDWGDGTAPTVGTVSGGVGGPFTVSGAHDYVELGLHTATVTMTSKGGSKASVSTATLSYSNPASGSFLLGGTRATGAVTYWGSQWAKSNGFTGSSSSLKGFANQTAPACGTTWKGSSATGATSLPPSTVPTYMAVTVTDKVTTTGTTATGLTRGVVIVRTNPGYGTAPSQVGTGTVVAVLCGTAG
>NZ_CP049867.1|WP_166084639.1|1192152_1193196_-|LLM-class-flavin-dependent-oxidoreductase
MTDFPRLSVLDLVPVRSDQTSSDALAAMRELARAADSLGYHRYWVAEHHNMPAVASTNPPVLIAMIAAATERIRVGSGGIMLPNHAPLVVAEQLALLEAAHPGRIDLGLGRAPGTDPVTSFALRHGAGGVSEDAVSRFPEYVDNVLTMMAPEGAQISVRGNQSVLRATPVAGGVPQVWLLGSSDYSARLAASRGLPYVFAHHFSGSGTAEALELYRSTFQPSEHLDAPRTFLTVNASVAESAEEARRRALPQLQMMLALRTGQPLGPQVLVEEAEKVDAPPAQVELLDKMAARYVIGDAGQARARVAELAASYGVDEVMVVPIAGAHVGTEPHSAPARLETLQLLAG

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Crispr_ID: NZ_CP049867_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_10

1274268-1274372

Orphan

Consensus_repeat	Method
CCGGGGCCCGGGTCTCGACGACGCTCGCTGGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_10

>merge|NZ_CP049867|10|1274268-1274372|CRISPRCasFinder
CCGGGGCCCGGGTCTCGACGACGCTCGCTGGCGCCCGCTGCTCCTTGGATCGAGCCCGTCGAGATCGACCACCGGGGCCGGGGTCTCGACGACGCTCGCTGGCGC

>NZ_CP049867|10|10|1274268-1274372|CRISPRCasFinder
CCGGGGCCCGGGTCTCGACGACGCTCGCTGGCGC	CCGCTGCTCCTTGGATCGAGCCCGTCGAGATCGACCA
CCGGGGCCGGGGTCTCGACGACGCTCGCTGGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166084717.1\|1285142_1285763_-\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|183245
NZ_CP049867.1\|WP_166084711.1\|1277806_1280191_+\|pyruvate-dehydrogenase	unknown	unknown	gnl\|CDD\|225329
NZ_CP049867.1\|WP_166089754.1\|1281435_1282902_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143432
NZ_CP049867.1\|WP_166084713.1\|1282914_1283259_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166084714.1\|1283285_1283807_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273344
NZ_CP049867.1\|WP_166084704.1\|1270439_1270733_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166084716.1\|1284006_1285005_-\|peptidase	unknown	unknown	gnl\|CDD\|226119
NZ_CP049867.1\|WP_166084705.1\|1270702_1271614_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238564
NZ_CP049867.1\|WP_166084702.1\|1266944_1269245_+\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|223700
NZ_CP049867.1\|WP_166084712.1\|1280278_1281256_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|373110
NZ_CP049867.1\|WP_166084708.1\|1274467_1275367_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166089746.1\|1269987_1270335_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224639
NZ_CP049867.1\|WP_166084703.1\|1269375_1269966_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166084707.1\|1273012_1274032_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176198
NZ_CP049867.1\|WP_166084700.1\|1265159_1265861_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235334
NZ_CP049867.1\|WP_166089752.1\|1276535_1277810_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP049867.1\|WP_166089750.1\|1271646_1272381_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NZ_CP049867.1\|WP_166084710.1\|1275540_1276509_+\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|163676
NZ_CP049867.1\|WP_166084706.1\|1272513_1273011_+\|DinB-family-protein	unknown	unknown	gnl\|CDD\|378981
NZ_CP049867.1\|WP_166084701.1\|1266044_1266323_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166089754.1\|1281435_1282902_+\|aldehyde-dehydrogenase	gnl\|CDD\|143432	cd07114, ALDH_DhaS, Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like. Uncharacterized aldehyde dehydrogenase from Candidatus pelagibacter (DhaS) and other related sequences are present in this CD.	0
NZ_CP049867.1\|WP_166084714.1\|1283285_1283807_-\|hypothetical-protein	gnl\|CDD\|273344	TIGR00927, retinal_rod, K+-dependent Na+/Ca+ exchanger. [Transport and binding proteins, Cations and iron carrying compounds].	0.000870504
NZ_CP049867.1\|WP_166084717.1\|1285142_1285763_-\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|183245	PRK11630, PRK11630, threonylcarbamoyl-AMP synthase.	2.71222e-77
NZ_CP049867.1\|WP_166084702.1\|1266944_1269245_+\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	1.09076e-05
NZ_CP049867.1\|WP_166084705.1\|1270702_1271614_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	8.84487e-54
NZ_CP049867.1\|WP_166084707.1\|1273012_1274032_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	6.5983e-95
NZ_CP049867.1\|WP_166089746.1\|1269987_1270335_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	2.00945e-24
NZ_CP049867.1\|WP_166084716.1\|1284006_1285005_-\|peptidase	gnl\|CDD\|226119	COG3591, COG3591, V8-like Glu-specific endopeptidase [Amino acid transport and metabolism].	6.79536e-06
NZ_CP049867.1\|WP_166084711.1\|1277806_1280191_+\|pyruvate-dehydrogenase	gnl\|CDD\|225329	COG2609, AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion].	4.31277e-146
NZ_CP049867.1\|WP_166084700.1\|1265159_1265861_+\|hypothetical-protein	gnl\|CDD\|235334	PRK05035, PRK05035, electron transport complex protein RnfC; Provisional.	9.90561e-09
NZ_CP049867.1\|WP_166089752.1\|1276535_1277810_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.46555e-126
NZ_CP049867.1\|WP_166089750.1\|1271646_1272381_+\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	1.78806e-15
NZ_CP049867.1\|WP_166084710.1\|1275540_1276509_+\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	4.01418e-100
NZ_CP049867.1\|WP_166084706.1\|1272513_1273011_+\|DinB-family-protein	gnl\|CDD\|378981	pfam12867, DinB_2, DinB superfamily. The DinB family are an uncharacterized family of potential enzymes. The structure of these proteins is composed of a four helix bundle.	8.62785e-09
NZ_CP049867.1\|WP_166084712.1\|1280278_1281256_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|373110	pfam14525, AraC_binding_2, AraC-binding-like domain. This domain is related to the AraC ligand binding domain pfam02311.	5.46745e-22

>NZ_CP049867.1|WP_166084707.1|1273012_1274032_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MRAAVLTGLEQVVLEDRPEPEAGPGWVVVKVEAASLCGTDVHQYDGRIDTPFPRVPGHDFSGRVESVGEEVDDSWVGRPVAVKPSLPCGDCPECHTDKPFDCKKKKLIGLWSDGCLTEKVAVPVVNLIPRPDGVEAWQAALLEPLAVGLNTVDRLRIMLGETVVVLGQGPIGLALTRLCALSGAGKLIVTDAREAPFTVSRAYGASDCLDVTQVDARQAVLDLTDGVGADIVIETSGFPASSAMCLDLVRKEGKVAHIGWANDLPPLPVIPIMAKTLTVFGIGGNGGRGQYERAQELVRTGRFDLDPVVTHRFSLDDIEEAFRVASSKSDGAIKVVVEP
>NZ_CP049867.1|WP_166084706.1|1272513_1273011_+|DinB-family-protein
MTDQVPEAISAALADADAALARLDDALGRLSDGDLHRAHFDGGWTVAQVVSHINMCAILWLGDLKRIEHDPELSFIFREEVGHDLTGYPPPTIEIARRQLASTRRSLATAGGAVGADVLSRVVEIPDLGTMTVEEWSPLIIGHASGHVEQAFEIMRNREFAPEGV
>NZ_CP049867.1|WP_166089750.1|1271646_1272381_+|VOC-family-protein
MSAFLDLPPGSFETGATFWSRVTGYDVSPRRGERDEFATLVPGDGDDFLRVQELEHGPGGIHLDLHVDSPAQEADRAVALGARVQHRSEHGYVVLDSPGGMTFCFVGHRASHRPAPAVWPGGHRSLVDQVCLDIPPSSYDAECTFWRDLTGESLHASSVSTQFQSLTRSAGQPLRLLLQRLDDEQERVTAHLDLAAEDREAETARHEELGAVVVGSHTRWTVLTDPVGAAYCITDRDPVTGLLA
>NZ_CP049867.1|WP_166084705.1|1270702_1271614_-|ABC-transporter-substrate-binding-protein
MRIVSLLPSATEILFDLGAGDDVVGVTFECDHPAEARQRRIVSTTALPAGLSPSEIDAFVAGAVARGEDLYHLDAGALADLDPDLVVTQDLCAVCAIDVDTVDGALQHLGCRAEVVTVDPQTLAQVLESVLTIGAATCRSDTAAGAVAAAKARLDVVRRRVAGRPRPRVLVLEWTDPPYSPGHWLPDLVEAAGGVVALGASGARSSRITWHDVRSAAADLVVVAPCGYDLDSASGLARQLVDDGLLPADVPVWAADANASWTRPALRLVDAVEDLAAVLHPAEDLPAPATLAAVHSSKSRASA
>NZ_CP049867.1|WP_166084704.1|1270439_1270733_+|hypothetical-protein
MSSEATRRAVDAAIVPLVASLGPWGVHEGHWLPGRDGHPVLWFRTRTEAEATALQGQVWLVAQVQVVLQRVGVPPSDVARVGLQFSSGQAEARLFEE
>NZ_CP049867.1|WP_166089746.1|1269987_1270335_-|GntR-family-transcriptional-regulator
MDSTSAVPPFEQLRSGIAGLVARGELPAGARLDTVRQLATDLGLAANTVAKAYRALEADGVITTEGRRGTFVRSRHLEKSSGTLDQDAAAFARSARRAGLSREEATRLLERAWES
>NZ_CP049867.1|WP_166084703.1|1269375_1269966_+|hypothetical-protein
MDSTVSTVGAPRRSTVLGSVAAVVALVATSVALAPPAHAETRTVVDEGGEALQGPAYQLLSGTMTYTHEQTKLTARIQRVSKERTWVGGSVYYADDSMLRVITTYRDGRRVTRGTFFTAGGSQTSVPVTSRWDLARDRVTMTVDNTAHDPKPGNERALLDVYTVTKGWMHGPHCDVRPNGELERCNDDYVSARLSR
>NZ_CP049867.1|WP_166084702.1|1266944_1269245_+|prolyl-oligopeptidase-family-serine-peptidase
MSRLLVSSLVALTTVLGTALPLAPASAADDVPVGAPAAAQRAEPKLGSPDGWPFTQQLSRTSGTGRLHDGASYWSDFVYDDHGAAVPSAFTVDNVAKLAPTQGVYEYPAGPAKGNGADVFVAAAGATDRATFWRVDWNTLAEPRVPIAVWTFDTDGDASTGGSDWPAGAGVRSDGIEKALVVSSRGAWLHDLQKGTSVDVTDRGGRLTVDRGTRSFVARVPRTLLPANGEWRVRLGAGLASPDGRTMATPSVAGGLPAVGLPRVYNLAFRTAQQEPPVHTDSMTAALQVAAQEALASTPPFDQLGADGLARYVTGNFWMEDNQADTLAGGDVSRFSQVVDWSRLARRVSTREPLVRGYSNRWYVSRLDLGAGVVANEGGATGDGRANYLSPVQPYGVYVPQGYEPGRGTPLTWILHSLDVNHNQYGAYDPLLMQQLCERRDSICATTLGRGPDGWYFDEAEEDFWAVWRSLGAAYSLSTRHTQLTGYSMGGYAAYKLGLAHPDLYAGAMSLAGPPKCGVSLDGDDLTTPAFGGRCTSDGGTVELVENARWTPYRVAQGFLDQLVPFTSVEAQVAAFDEAGLRHLFVRYPGEDHLVFATQDRFATVVEGLGRPAAERNPHVVDYTWRPHLTRRDLGIGATTAWWTSQLQARSDAPGSLARVQARTSGLRARAHDVVRSGPTPVTSPLPAIVTALEWVAGDLLDQRQRLEIELSNVRRVAVDMARAGLRCGIVDVTSDGTAKLVLTDLPGADRVLDVTAGERRYRLPC
>NZ_CP049867.1|WP_166084701.1|1266044_1266323_+|hypothetical-protein
MSKMDALRAMREERYEQAQRTAAGGAARAAQPARRTTAATRPPVAPPATDREEKATDASAPEPVEALCGHKNMGGRSCTRPAGHSEKSHRYS
>NZ_CP049867.1|WP_166084700.1|1265159_1265861_+|hypothetical-protein
MATAKFDIKPATRPLYAGVGVTDRAVEAVRGSLAHSQKRINDVQQDARQIDLDTVTREAKARRAAVEARFTELQKSVQSVPSRIQARITAELSERELTYGQLVDRGETLVERIRRQSSTQETKRNAKTTSSKAKTTRTQGKKAAGTTRSQAKGAATSTANTAKNQAASTAEAAKGAAKSTASTAKSGAKSTRTTAKNQSSRPSSSAKATGTAAKKTATSAAKATKDAAAKVGD
>NZ_CP049867.1|WP_166084708.1|1274467_1275367_-|hypothetical-protein
MDYTEARAAFFGEREGDARPLDWTSPARRLRDAIEPIATICFWSEPAYDAYAAEGLDFLQGYVYGRGCVLGDAEPAVAAAAFGVFEPGLVADLFASGRATCSVEAVRAAKQHGAVAALRECIGDPEELADVVAVLRRACEAADPTGRALHAGLTSLPWPDDLVGQLWHACSILREHRGDGHLAALVAAGVDGVQANQLTELWVGWDPLAYTGSRAWAPETMGAGTASLEARGWVADGALTDAGRQVREDLETATDRSVQVAVDALGDDLDRVVVLLDDWAGRVVARGWFPPDPYKRASG
>NZ_CP049867.1|WP_166084710.1|1275540_1276509_+|hydroxymethylglutaryl-CoA-lyase
MTTRPPAVVDLVEVGPRDGLQNEARTLDVDTRVELVRRLVADGARRVEAVSFVRPARVPQMAGAEEVMDGLRGLDASLIGLVLNRRGAERAAAASCDEVNVVVPVTDDFSVRNQGVPVDGMMEHAAAAVTVAREAGMGVSVTLAVAFGCPFSGIVTTAQVAAVVDRVADLGIDELAFADTVGVGVPPQVLDLAALVADDDRVPRLRFHFHNTRNTGYANAWAATTLDLSGHGGRVALDASVGGFGGCPFAPAATGNIAMEDLVHQLRRAGTPTAAPAPRVDALVGVAGWLAGQLDSPVQALLGKAGDFPGDLPHDLIVGRQA
>NZ_CP049867.1|WP_166089752.1|1276535_1277810_+|CoA-transferase
MDADRPLRGIRVVELGNYIAAPTAGRLLADFGAEVVKVERPRTGDELRTWRLYAGETSMLYRTINRNKRSVEIDLRTEEGRDTVLDLVRRSDALIENFRPGTLDRWGLSADVLSEANPELVVARVSAFGQTGPMAGRPGFAAVAEAFGGMRDLVGDADRPPARVGVSIGDSIAGLYAAFGVVMSLFDREQRRRLAADPVTPSDRHVDVALHEAVFSMMESLVPDYSAYDVLRQRTGGRMEGIAPSNAYLCADETSVVIAGNGDSIFGRLMRTIGRDDLAEDADLAGNAGRWARRDELDEAIETWTRRLPRAEVLRVLDEASVPAGPIYRAEDIVDDPQYRARGMVQHLPIEVEGAVREVAFPGIVPVVGQVSLPIETLGPDLGQDTAWMLGLLGRGPDAGTPTAGRDPDPDPDTDTDTEDEATA
>NZ_CP049867.1|WP_166084711.1|1277806_1280191_+|pyruvate-dehydrogenase
MTELHDDETDQPERRRATDADAPAAPDLETLREVSRTVLWLSAAIVDAANRGRPNPSGIKVGGHQASSASMVDIMVALWFHELTALDRVSVKPHASPVLHAVNYLLGDLDERYLPTLRARGGLQSYPSRSKDPDTVDFSTGSVGIGATAALWAAIAHRYVRSQFADAPPAGRFVSLLGDAELDEGAIWEAVADPQVASLGELLWVVDMNRQSLDRVVPDIQIQRLSAMFHAAGWQVVTLKWGRLISALFNRPGGDHLRRRLEAMPNEEYQRMLRVDSAEIAERIMGPDGSDGSPELQELLQSTPTAHLAAAVRDLGGHDLGLLVDTFGSVDDHRPTVVFAYTVKGRGLPTEGHPNNHSVLLTEPQMQSLADATGADLADPWRRFDDGSAAAALCRQRRTALTRRGVTPTGDVEVPTELGHPHRKAVSTQATLGRLLADLVRDAPGAASRVVTCSPDVASSTNLGGWINKTGVWSVTERHDWFADDEQRVLRWAESQSGQHIELGIAEVNLVGLLGELGATWSRWGERLIPIATLYDPFLARALEPWSFGLYAGGQSILVGTPSGVTLAPEGGAHQSVSTPSIGLEQPGCVAWEPAFAQDLEWCFLHAMRSVGVPGGTSAYFRLTTRPVDPALAAVPEDEVLRERRRRQAVSGGYRVTSHDPATEDVTLVGVGAVMPEVLDAARRLGEAGVVAGVVCLTSPDLVFRSFQQRGSRAMGGGSGVLDLLLPAAHPAPLVTVLDGHPHTLAFLAGARGDAIRCLGVTEFGQSSDLADAYALHGLDALSVVEAALDLLGR
>NZ_CP049867.1|WP_166084712.1|1280278_1281256_+|AraC-family-transcriptional-regulator
MPTQEYLTDDVVMSTRSLEEARDAVTRVYLPHELVGEHDAIDMRLNAVSDRFLTLGYLTYQADTELRMPAAEQWYHVNLQLTGATWAHRSDGTREHTPARTRGLVLNPSQRNTVRWSPDAEQLILKVPRSGLESHLADLIGRPVTEAVDFDFGLDLSTAPGMTLLRSVELLATELERPGGLRDMPLARAQLESYVLTALLHAGRHQYTDALAGREDGARLGRLAPVVRYIEEHADAELTPELLARVACVSVRTLHAAFSEQLGESPMAYVRRIRLGKVRADLLRADPQRERVTDIALRWGFFHQSRFAQQYREQFHELPSATLQR
>NZ_CP049867.1|WP_166089754.1|1281435_1282902_+|aldehyde-dehydrogenase
MERFGLFIGGQVVEAASGRTFESTNPYTGRSWAVLADGAPEDVDRAVASARAAFEGEWGQMSGFARADVLRRVATAITENAERLALLEVRDSGKLMREMRGQLQALGTWYSYFSGLADKIEGKTVPAVNPAAYFGYTLRQPVGVVGAITPWNSPLLLLTFKLAPLLAAGCTCVVKPSEHAPASTVAFAQVLHEAGLPAGVLNVVTGWDRSTGESLASHQGVDKVAFTGSTATGAKVAQAAVANINKVTLELGGKSPQVVFADADLDAAANGLVAGVFAATGQTCMAGSRLIVHESVKDELVAKVVERANAIKQGDPTADDTEMGPVANRPQYEKVLGYLDGARDEGWTIACGGEPNADLGGLFVRPTVVLADPTATIVKEEVFGPVLSAYTFTDEEEAVRLANDTPYGLAGAVWTKDVHRAHRVAARLQAGTVWINAYRVVAPNMPFGGFGLSGIGRENGSDAVDEYLENKSVFVELTGGTRDPFKLG
>NZ_CP049867.1|WP_166084713.1|1282914_1283259_-|hypothetical-protein
MSRPDPDAWDPQRFVTEPPVPRPNRDALGQSLRAACALMLTTLVALALALLPEVDRAVRVAVEFTVLPFLLAAVFIALVAWSSPRAWRVRTYLVGVGAFGVVVITVVLLASGRS
>NZ_CP049867.1|WP_166084714.1|1283285_1283807_-|hypothetical-protein
MSESAHDDSSTDTQTEEQADGSTETESQQASGSSDDSGSDGEQDNGYDPAEKEPGSDEGQGASEDDKVEKVESEGFDVDEVDIDDRDHTEDDEDEIEKEREERLKPENRPENAEVDNTQRTFLPEKGVFEDSPDEARPEGDPTFEEESITEGSDDDDDSSDDADEDDADAKDD
>NZ_CP049867.1|WP_166084716.1|1284006_1285005_-|peptidase
MRNLKRPTALAGVTGMLLAGLLAAGNGTAEAAPERDSRAAVVGHRTAAASDAAAAERIRDYWTPKRMRAADPLVVSPSTSSDTTVERGTPQTVRGQVAKGKPGGGSSSGYLGGPWTGGGNVVKTTGKVFFTLGGSNYVCSGSAVTSPNKSTVTTAGHCLNEGPGDYASNFSFVPAYDNGSAPYGEWVATQLFTTTEWATTGDYNYDVGMAKVGTLNGATLTETVGSQGIGFNQARGQFVHAFGYPAASPYDGQELDYCSGTTTNDTRGTQDMRLACNMTGGSSGGPWFQQFSGGNGVQVSVNSFGYRGEKNAMYGPYFGSVIQTLYTTASAS
>NZ_CP049867.1|WP_166084717.1|1285142_1285763_-|threonylcarbamoyl-AMP-synthase
MARFVDVHPQDPQPRRIAQVVEMLRDDALVAYPTDSGYALGTRLDNPQGTERIKRIRQLDDKHHFTLVCADFGQLGQLVQLSNAAFRAVKAATPGPYTFILPATREVPRRLAHPKKRTVGVRIPDHPVVRALLRELGEPLLSSTLLLPDHPEPLTDGWQIKEELDHAVDVVIDAGDCGTEPTTVVDWSEGAPEVTRVGAGDPDRFA

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Crispr_ID: NZ_CP049867_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_11

2829284-2829370

Orphan

Consensus_repeat	Method
TCACTAGGTACCTAGTGAAACTGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_11

>merge|NZ_CP049867|11|2829284-2829370|CRISPRCasFinder
TCACTAGGTACCTAGTGAAACTGGCGCTTCCCGAACGAAACTTCACTCGGGAAGCGCCGGGATCACTAGGTACCTAGTGAAACTGGC

>NZ_CP049867|11|11|2829284-2829370|CRISPRCasFinder
TCACTAGGTACCTAGTGAAACTGGC	GCTTCCCGAACGAAACTTCACTCGGGAAGCGCCGGGA
TCACTAGGTACCTAGTGAAACTGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166087122.1\|2840507_2842607_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP049867.1\|WP_166087118.1\|2836295_2837654_-\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|99743
NZ_CP049867.1\|WP_166087104.1\|2827019_2827820_-\|3-oxoacyl-ACP-reductase	unknown	unknown	gnl\|CDD\|180371
NZ_CP049867.1\|WP_166087102.1\|2826244_2827009_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|224982
NZ_CP049867.1\|WP_166087114.1\|2835089_2835890_+\|META-domain-containing-protein	unknown	unknown	gnl\|CDD\|377111
NZ_CP049867.1\|WP_166090142.1\|2838879_2840304_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP049867.1\|WP_166087092.1\|2821679_2822282_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NZ_CP049867.1\|WP_166087110.1\|2832006_2833896_-\|alpha-amylase	unknown	unknown	gnl\|CDD\|200463
NZ_CP049867.1\|WP_166087094.1\|2822994_2824200_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP049867.1\|WP_166087088.1\|2819994_2820501_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP049867.1\|WP_166090137.1\|2822278_2822944_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP049867.1\|WP_166087108.1\|2831007_2831940_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235737
NZ_CP049867.1\|WP_166087099.1\|2825517_2826156_-\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|224187
NZ_CP049867.1\|WP_166090140.1\|2827876_2829223_-\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|365919
NZ_CP049867.1\|WP_166087120.1\|2837653_2838691_-\|agmatinase	unknown	unknown	gnl\|CDD\|212516
NZ_CP049867.1\|WP_166087096.1\|2824196_2825444_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341228
NZ_CP049867.1\|WP_166087112.1\|2833989_2834886_+\|MerR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378377
NZ_CP049867.1\|WP_166087106.1\|2829374_2830742_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NZ_CP049867.1\|WP_166087090.1\|2820500_2821634_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166087116.1\|2835903_2836299_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166087122.1\|2840507_2842607_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	4.19975e-68
NZ_CP049867.1\|WP_166087118.1\|2836295_2837654_-\|aspartate-aminotransferase-family-protein	gnl\|CDD\|99743	cd06450, DOPA_deC_like, DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.	5.89854e-62
NZ_CP049867.1\|WP_166087104.1\|2827019_2827820_-\|3-oxoacyl-ACP-reductase	gnl\|CDD\|180371	PRK06057, PRK06057, short chain dehydrogenase; Provisional.	1.3564e-167
NZ_CP049867.1\|WP_166087102.1\|2826244_2827009_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl\|CDD\|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	3.21228e-58
NZ_CP049867.1\|WP_166087114.1\|2835089_2835890_+\|META-domain-containing-protein	gnl\|CDD\|377111	pfam03724, META, META domain. Small domain family found in proteins of of unknown function. Some are secreted and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene. Over-expression in L.amazonensis increases virulence. A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.	6.22407e-14
NZ_CP049867.1\|WP_166087092.1\|2821679_2822282_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	8.82135e-21
NZ_CP049867.1\|WP_166087110.1\|2832006_2833896_-\|alpha-amylase	gnl\|CDD\|200463	cd11324, AmyAc_Amylosucrase, Alpha amylase catalytic domain found in Amylosucrase. Amylosucrase is a glucosyltransferase that catalyzes the transfer of a D-glucopyranosyl moiety from sucrose onto an acceptor molecule. When the acceptor is another saccharide, only alpha-1,4 linkages are produced. Unlike most amylopolysaccharide synthases, it does not require any alpha-D-glucosyl nucleoside diphosphate substrate. In the presence of glycogen it catalyzes the transfer of a D-glucose moiety onto a glycogen branch, but in its absence, it hydrolyzes sucrose and synthesizes polymers, smaller maltosaccharides, and sucrose isoforms. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP049867.1\|WP_166087094.1\|2822994_2824200_-\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	4.03531e-127
NZ_CP049867.1\|WP_166087088.1\|2819994_2820501_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	6.41959e-46
NZ_CP049867.1\|WP_166090137.1\|2822278_2822944_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	1.75098e-81
NZ_CP049867.1\|WP_166087108.1\|2831007_2831940_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	2.87214e-101
NZ_CP049867.1\|WP_166087099.1\|2825517_2826156_-\|biotin-transporter-BioY	gnl\|CDD\|224187	COG1268, BioY, Uncharacterized conserved protein [General function prediction only].	2.60173e-38
NZ_CP049867.1\|WP_166087120.1\|2837653_2838691_-\|agmatinase	gnl\|CDD\|212516	cd09990, Agmatinase-like, Agmatinase-like family. Agmatinase subfamily currently includes metalloenzymes such as agmatinase, guanidinobutyrase, guanidopropionase, formimidoylglutamase and proclavaminate amidinohydrolase. Agmatinase (agmatine ureohydrolase; SpeB; EC=3.5.3.11) is the key enzyme in the synthesis of polyamine putrescine; it catalyzes hydrolysis of agmatine to yield putrescine and urea. This enzyme has been found in bacteria, archaea and eukaryotes, requiring divalent Mn and sometimes Zn, Co or Ca for activity. In mammals, the highest level of agmatinase mRNA was found in liver and kidney. However, catabolism of agmatine via agmatinase apparently is a not major path; it is mostly catabolized via diamine oxidase. Agmatinase has been shown to be down-regulated in tumor renal cells. Guanidinobutyrase (Gbh, EC=3.5.3.7) catalyzes hydrolysis of 4-guanidinobutanoate to yield 4-aminobutanoate and urea in arginine degradation pathway. Activity has been shown for purified enzyme from Arthrobacter sp. KUJ 8602. Additionally, guanidinobutyrase is able to hydrolyze D-arginine, 3-guanidinopropionate, 5-guanidinovaleriate and L-arginine with much less affinity, having divalent Zn ions for catalysis. Proclavaminate amidinohydrolase (Pah, EC 3.5.3.22) hydrolyzes amidinoproclavaminate to yield proclavaminate and urea in clavulanic acid biosynthesis. Activity has been shown for purified enzyme from Streptomyces clavuligerus. Clavulanic acid is the effective inhibitor of beta-lactamases. This acid is used in combination with the penicillin amoxicillin to prevent antibiotic's beta-lactam rings from hydrolysis, thus keeping the antibiotics biologically active.	2.57198e-119
NZ_CP049867.1\|WP_166087096.1\|2824196_2825444_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341228	cd04433, AFD_class_I, Adenylate forming domain, Class I, also known as the ANL superfamily. This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.	2.30982e-21
NZ_CP049867.1\|WP_166087112.1\|2833989_2834886_+\|MerR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|378377	pfam10069, DICT, Sensory domain in DIguanylate Cyclases and Two-component system. DICT is a sensory domain found associated with GGDEF, EAL, HD-GYP, STAS, and two component systems (histidine-kinase type). It assumes an alpha+beta fold with a 4-stranded beta-sheet and might have a role in light response (Natural history of sensor domains in bacterial signaling systems by Aravind L, LM Iyer, Anantharaman V, from 'Sensory Mechanisms in Bacteria: Molecular Aspects of Signal Recognition.' Caister Academic Press. 2010) - see (http://de.scribd.com/doc/28576661/Bacterial-Signaling-Chapter).	1.46406e-15
NZ_CP049867.1\|WP_166087106.1\|2829374_2830742_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	6.71268e-134
NZ_CP049867.1\|WP_166090140.1\|2827876_2829223_-\|aldehyde-dehydrogenase	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	0
NZ_CP049867.1\|WP_166090142.1\|2838879_2840304_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.19081e-70

>NZ_CP049867.1|WP_166090140.1|2827876_2829223_-|aldehyde-dehydrogenase
MNPATAEPVTEVQLASEAETDALIERAHEAFPAWRDVAPGERARLLRRFAALVDEHLDELAGLEVRNAGHTWGNARWEAGNVRDVLNYYSAAPERMHGRQIPVSGGIDVTFHEPLGVVGIIVPWNFPMPIAGWGLAPALAAGNTVVLKPAELTPLTAIRLGELGREAGLPEGVLTIIPGAGSVVGNRFVTHPLVRKVCFTGSTAVGKKIMAGAADQVKRVTLELGGKSSNVVFADADIAAAAASAPYAVFDNAGQDCCARSRILVERPAYDEFLGRLEQAVTGMRVTDPGADPDSEMGPLISATQKERVAGYLTDVEVAFTGSAPDSAGFWVPPTVVLPGGTDDAVWREEVFGPVVAVLPFDSEEEAVRLANDTEYGLSGSIFTSDVGRALRVSRGVAAGNLSVNSHSAVRYWTPFGGFKQSGLGRELGPDAPLAFTEEKNVFIADGS
>NZ_CP049867.1|WP_166087104.1|2827019_2827820_-|3-oxoacyl-ACP-reductase
MTVPEKGRTGGRAGRLDGKVAVVTGGVSGIGLATVRRFLEEDATVVVGDLDDVRGEELAAELGFHYLHTDVTSKEDVDRLFTSTKERFGSVDVAFNNAGIAPPEDDSILDTDLEAWRKVQEVNLTSVYLCCKAVLPIMIEQGRGSIINTASFVAVMGAATSQISYSASKGGVLSMSRELGVQFARDGVRVNALCPGPVNTPLLQELFARDAERAARRLVHVPMGRFAEPVEMANAVLFLASDESSFMTANTFLVDGGISGAYVTPL
>NZ_CP049867.1|WP_166087102.1|2826244_2827009_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MGASEGERRPLIGLTTYRETATWGIWDTTADVLPAVYARALEVAGAAVVLLPPQHPDGGAPEAVVAALDGLVVTGGADVSPHRYADAPHERTQAWRDDRDAWELALLEAAAARALPVLGICRGMQVMAVAAGGRLEQHVPDRVGHENHSPGGDVFGEVAVAVREGTRVHDLVGDRLTVRCHHHQGVLEHPGFDPVAWAADETLEAMERPGDRFEVAVQWHPEMVEDAGLFRGVVAAARAGRGSGQGPGGPGHPA
>NZ_CP049867.1|WP_166087099.1|2825517_2826156_-|biotin-transporter-BioY
MTGTTGRQHGGSARGRVFTARDLALVAVFAGVMAALGLVPAWTAPGFSVPITAQSMGVMLAGGVLGGRRGALSMLVFLALVAIGLPVLAGGRGGLGVFAGPSVGFLVGFPVAAYVVGVLSERLHGVASATGRLAAALVANLVGGVVVLYVFGVLGMAVNLRIPIDEATTLLWIYVPGDLVKVVVAALVVRAVHAGYPGLLDRAPRRKQTSSV
>NZ_CP049867.1|WP_166087096.1|2824196_2825444_-|long-chain-fatty-acid--CoA-ligase
MAGAVDVAAAADPAGAVLAAHRAGRRIVLTTSGTAGRPRRIVRTTASWFDSFPVVARLTGLDASSRMWLPGRAPDGPGRVGHGSTLSLFAEVLARHTGAACVARPEDATHAHLTPGQLERSLDGLAAARASHPVHVTVAGEALPGALRERAEAAGLRVSRYYGAAELSFVAWAVGDAGLRPFPGVEVDVRDGEVWARSPYLSDGYAGGTPQTDDAGGTLRTHAAGGTMRTDAAGGTEADMDTDTHTDTGGALRTAPDGFATVGDRGRWETERAADGGGRVLVVTGRGDDAVTTAAATVLVADVEAALRPVVTGAFAVLGLPHTSLGQVLAAVLTNPSDLEPAQAAARGLTAAQRPRLWFLRDGLPVAASGKTDRAALRREAAALHASAPDTSAPDPSAPDGGNRPLRRLVPERAR
>NZ_CP049867.1|WP_166087094.1|2822994_2824200_-|thiolase-family-protein
MTRRGTEPEAPCVVDALRTPIGTAGRGLASLTAADLAAPVLSALVDRLPAGAGAVHEVVLGNCMGPGGDVARVATLQAGLEPATLGWGRDVPAVTVDRQCASGLAAVVQGAATLTATPGPGVVLAGGVESASTAPWRFWPPGPDATASGSDAPTLQRYERAPFAPAALGDPDMGVANDLLAAEAGVTRAEQDGYAARSHARAVATAAAGGFDAELVLVGGLARDERPRDGLGVERLARLRPAFREDGTVTAGNSCGINDGAAAATLVTDDVRRSLGLPGLRIRSTATVAFDPDRPGHGLVPATRLALERAGVGLADLAVVELNEAFAGQVLACCRALALDPERVCPEGGALALGHPWGASGSVLVVRLFSQLVRSGRGGLGLAAIAAGGGQGVAVVVEAVA
>NZ_CP049867.1|WP_166090137.1|2822278_2822944_-|ABC-transporter-ATP-binding-protein
MVGSRAGRPVLRDVDVTLTERRVGVIGANGSGKSTFVRLLNGLVLPDEGRVRVHGLDTRDDSRAVRRLVGFCFTNPDAQIVMPTVREDVAFGLRRRGLSKGEVRARVDEALVRYGLDGHADHPAHLLSGGQKQMLALASVLVTEPEVLVLDEPTTLLDLRNARRVAETVTALPQQVLLVTHHLDLLDDYDRVLVFDEGRLVHDGPPAVSVAHYRDLMAARP
>NZ_CP049867.1|WP_166087092.1|2821679_2822282_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MSQLGLFVPGTSVVHRLPARVKLGALVAAGVGSLWLDTLPRVGLMWLALVLAYAVARIPLRSVVAQIRPLALILGAVVVFQVLVAGWERAVVVVGVVGALVLLAGLVTLTTRTQDLLDVVVAVVRPLRHVGVDPERVGLLMALAIRSVPVVLGLAEEVRDAQRARGVRPSARAYAAPLIIRAVRHADDLGEALVARGVDD
>NZ_CP049867.1|WP_166087090.1|2820500_2821634_+|hypothetical-protein
MDSELEQTLARDLDDVASRLVVPTMPTLPSSPPGGWSRRHRAAPLLLAAAVLATALATVATILSLTGPAADGPVAPPTPAPSAEGAISGAAPDVPAVVAGTLLVGGEQVPGEWLNVQGTGTRWVGQRADGGWRWGFDTEPQRMDGAMEQPPVMSPNGGYTARVVSDAGSAMLIGADTEFGGEGFGGVDVPVDPQGPPPRAAAVTDDGLVVAGGPGFQLLWRPLVDNETVDLAETAPGQVVLDGTAAGLVVNEGEYGATDGTQGEPYLARVSEDGSLERLGSVPTHDVLEASEQWLAFVPPGTVGGEASAAPDLRVQRLDGSADGTLSPPQGWLFVAPGFRWESEDSLVGLVVTQDGGDEGLVRCRPEPAACRLLDLP
>NZ_CP049867.1|WP_166087088.1|2819994_2820501_+|SigE-family-RNA-polymerase-sigma-factor
MPTYTEAELPTFEEYAAAAWPSLYRRAYLLCGNHADAEDLAQASLIKIHASWTKVSRAESPHAYVRRILTNTFLSTKRHKGRRLELLAGDHAPEPTSPPVEGPEDRMALWPHVRDLPKRQRAVIVLRYYEQLSEAEIADALDCSRGNVKSTAHRALQNLRTALDGRDE
>NZ_CP049867.1|WP_166087106.1|2829374_2830742_-|glutamine-synthetase
MPRNDRHLTEDALRAAIEKDEIDTVVVAFTDMQGRLQGKRLHGRYFLDHVLGEGKTEGCNYLLGVDVDMNTVDGYAITSWEQGYGDMEFVLDLETIRLLPNEPAAAMIQCDLTWPDHTPVAQSPRAILAAQMKRAADLGYVAVAGTELEFIIMEDTYEEAFTKGYRDLVPSNQYNIDYSILGTHRVEPLLREIRNTMYAAGMNTEAAKGECNFGQHEIGFLFDDVMVTADNHAVYKEVAKQIAVKHGKSITFMAKFNQREGSSCHIHLSLRGKDGEIVFWDDKAGKTTPLYDRFVAGVLATMRDFTLLYAPNINSYKRFAHGSFAPTAIAWGNDNRTCAVRLVGEGPAARMENRVPGGDVNPYLALAAMLAGGLHGIEKKLTLEPPLTGSAYDSDAPKVPHTMNEAREAFTTSKVARAALGDEVVDHYTNMADVELADYDATVTDWELRRGFERL
>NZ_CP049867.1|WP_166087108.1|2831007_2831940_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSRWTTDDLGDLTGRRALVTGANSGIGLHTAQELARHGAEVTLAVRDAAKGESAADGVRSALAGAQGAGEVRVAALDLASLDSVEKLAADWQGPLDLLVNNAGVMTPPRYQETSDGFELQFGTNHLGHFALTGWLLGALRAAASARVVTVSSIAHHGGRPDVLAGNPRAGYNASRAYSNSKLANLLFAAELQRRARAAGVPLTSVAAHPGVSATNLVTSEQGLGSIPGVRIVAPLFLKLAFQSPRAGALPVLYAATVADPPPYTGPQGLRESRGKHPGPARLQPLARDEELAAQLWQVSEERTGVRFDWA
>NZ_CP049867.1|WP_166087110.1|2832006_2833896_-|alpha-amylase
MPAHVPPVPPVPDALTGLPAHLVELFTARLERWWPDLLAGLAVYPDPEAVARRVVDLAAAGFAARDAELHHLDLRRSLAPDWFQDPAALGYAAYADRFAGDLAGVAERLDHLEGLGVTYLHLMPLLQPRPAPNDGGYAVADYRAVREDLGTTDDLRALATRLRARGMSLCLDLVLNHVATEHEWARRAKAGEAEYRAYFHLFDDRRMPDAYEQTLPEVFPDIAPGSFTWDDEVEAWVWTTFNTYQWDVDWSNPDVFCAYADIVLHLANLGVEVFRLDAIAFLWKRLGTNCQNQPEVHALTQALRTVVRIACPAVVFKAEAIVGPRDLPAYLGAGEHHGKVSDLAYHNGLMVQVWSMLASRDVRLATYALQQLPPTPPTTAWITYARCHDDIGWAIDDGDAAAMGVSGFAHRSFLSDFYSGEFPGSWARGLVFGENEETGDRRISGSLASLAGLECGDPWALNRILLVHALVLGFGGLPVLWMGDEVGLLNDLGWATEEGHADDNRWAHRPRMPWGGDGRPEDPHGLLPRITALVQARRGTPHLHASVPTRVEWPEDPGVLLTVRDHPLGPMVGAYNVTDTGRSVTTAKLRHLGLDGRVLDRLAPHRAPHRLSSVREVELPPYAAMWLTR
>NZ_CP049867.1|WP_166087112.1|2833989_2834886_+|MerR-family-DNA-binding-transcriptional-regulator
MTTSWAKSGQRAGQNGREVNPGTLTIGELSRRTGISASNLRMWESRYGFPLALRLPSGHRRYPEEVVDSILRVKQRREVGVRLEAAITEVSQFAASPATSVWAELRERHPHLRPHRLRKSTLLALSWALEDECCARASSPWLFGAFQREKYYRRAEGRWRDLARTSRGTWALADFPDNVARPDAPFEVALPDGAPMHREWTLACLAEDFPAVLTAWEIPGQVGVVDRDRVFESVWSLEPEPVRDASRTLAHIVADAGCDTRAVLHDLDRMRVPEPHHRDLRRATDLFNRVVAYVEKVR
>NZ_CP049867.1|WP_166087114.1|2835089_2835890_+|META-domain-containing-protein
MTLPVIAVLTLLALAVAGCGDTTAGSDGDAAGPGAGASDSGRATAAPADGVYVATDVSGRSLVEGTRVRLTWKGDQLSADAGCNQMSGSASVADGRLVVTGLGMTEMGCEPGRMEQDEWVADLLTSRPRIATGADGFTLTGQSVTARFATEPPPEDVSLEGTTWLLESTVDGDVASSSVGGPAASTPRFRIADGRVVGFDGCDELSGPVDVTADSIAAGGDLGGTERQCLVAGAPLADLLGGSTYVVEGDRLTLTRGEISLVLRAE
>NZ_CP049867.1|WP_166087116.1|2835903_2836299_-|hypothetical-protein
MRAALLAAVGALVLGGCGGESVIADGSYAAEPSDVSAQVLTAPLRLAWRGDEVEVETGCTRIVAQAEVDEVGDAATLRLAAVESTSTCNPPDSDPDVWVEAFLRTGPTVERSEGGGFQLFDEEVSVSFHPE
>NZ_CP049867.1|WP_166087118.1|2836295_2837654_-|aspartate-aminotransferase-family-protein
MHSVDQTTEQMVRSVLAYAENRLRMDPVPLDKATLDPARLHDRLRGVIREEPRQPDEVLGVYASVIAPSVISADSPRFLGFIPAAPTKASLLFDMLVSCASIQGISWLEASGAIAAENSVLTLLAAEMGMPPTAGGCFVSGGSAGNLSALAVARETAKRERTLTGRPQVVVSLDAHSSIINTLMLLEMDALVVETDDHRLTRSAVERMIARTDAAVLDDVVAVVCTSGTTNAGIIDDLDGVGALAEERGWWFHVDGAYGGAGVLVPSLKPKYAGIERADSFIVDPHKWMFTPFDCCALVYKRPELARRTHTQDASYLDVIRDQGGEWNPTDYAYHLTRRARGLPLWFSLAVNGLGAYREAIEVSVDLAKAAADLVRAEDHLELVREPDLGIVLFRRLGWEHDDYDAWARKLHDDEVAFIPPSKWDGETVGRFAFLHPDTTLDVVREVLERTR
>NZ_CP049867.1|WP_166087120.1|2837653_2838691_-|agmatinase
MTRYGQQFGPDFTFLGVDRCDLDEPATYADADVVILGAPFDGGTSHRPGARFGPQAIREQDYLPHDGSRPSLALRTDGLKDLRVVDAGDVEMYSGDIERSLPALEAAVEKVARAGAIPVVLGGDHSIAYPDAKGVANVLGHGRVSMIHFDAHADTGDIEFGSLWGHGQPMRRLIESGALRGDRFLQMGLRGYWPEPDTLDWMAGKTMRSYEMTEIVHRGFAECLTEAFAIATDECEGVFLSVDVDVCDPGHAPGTGTPEPGGLTARELLDAVRRICLELPVVGVDVVEVSPPYDHAGITAALANRVVLESLSAIARRRQDARDGTTWNPLQPLLEGRGTPGEGER
>NZ_CP049867.1|WP_166090142.1|2838879_2840304_+|MFS-transporter
MAMLDGTIVNVALPAIGEDLDAGIGGLQWTVNGYTLTLAAFILLGGAAGDRFGRRRVFLVGVVGFALASLLCGLAPNVETLVAARALQGVAGALLTPGSLAILQASFSGPDRGRAIGAWSGLGGIAAAVGPFLGGWLVDVASWRWVFLLNVPVALAVVAVAVRHVPESRDPDSVPGTDVRGAALGVLFLSGLTFALVSWGERGLTAAPTWGALVLAVTAGAAFVRVERRAAHPMLPPDIFVSPLFRVTNVVTFVVYAALGGIFFLLVLTLQTAVGFGPVLAGASLLPITVIMLALSARAGELAERIGPRLPMTVGPALSAAGTLLLLRVDQDASYVADVLPGVTLFGLGLAATVAPLTTTVLAAAPDRHAGLASGVNNAVARTAGLLAVAALPVVVGLNAAYGDPAAEIAAFHRAALVCAGLLALGSVVAATRVRRSAASAGPDEPLPEPSPCRRHCAVEAPPWQPADEPVPTP
>NZ_CP049867.1|WP_166087122.1|2840507_2842607_-|S9-family-peptidase
MSSDATDPTDRTTATHGAWPSPFSARDTVTAGTVRTTPVVGGRSVWWLEARPTDAGRLTLVRGEAGEAVDVSAAGCNVRTAFHEYGGGAVAVGGPDGGLALYVDFSDQRVHRVDVVSGEQGVEVGQPRPVTPDTGGQVRWSCFRVDAARGVAFCLREDQRDPSVEPVTSLVRIDLDGPNEDLGVVLVAGKRRPVDRGPEAGAEEGPDFVLDPTLSPDGRRIAWLQWDHPNMAWIGTWLWVASVDEAGDLHDARVVAGGVSESVEQPRWLSDDRVVFLSDRSGWSNFSAVQLAPLDAAGTAPAASSEPVVLAPEERDFGQPRWTPDQSSYDLLPDGRIVTTRFTDGFCSVCLLDPATGEVTEVPTDVTGVFDLRAVGEHHATCRATFTDRPSDVVTIDLRDGTTRSVSGQPEAPDPAWVSTPEAVSWTSLTELGGDGATAHGFLYPPTNPDAAAPDGELPPLIVTLHGGPTAAAPAAYTRARTFWTSRGFAVLDVNYAGSTGYGRAYRERLDGQWGVAEVADVASGARHLADQGRVDPAKVAITGGSAGGYTTLAALTFTDAFAAGASHFGISDLAALARDTHKLESRYLDGLVAPWPSGEDVYTARSPIHHVDRLATPLILLQGTEDKVVPPDQAELMFEAVRVKGLPVALVMFDGEGHGFRDPANQARALESELSFYGQVFGFTPAGDVPVVEVENLP

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Crispr_ID: NZ_CP049867_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_12

3049138-3049241

Orphan

Consensus_repeat	Method
CGCAACCTGCTCGACCACCGGGTGCGCGCGACCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_12

>merge|NZ_CP049867|12|3049138-3049241|CRISPRCasFinder
CGCAACCTGCTCGACCACCGGGTGCGCGCGACCACCCGGGAGTCACCAGGTCTCGACAACGGTTGCTGCGCAACCTGCTCGACCACCGGGTGCGCGCGACCACC

>NZ_CP049867|12|12|3049138-3049241|CRISPRCasFinder
CGCAACCTGCTCGACCACCGGGTGCGCGCGACCACC	CGGGAGTCACCAGGTCTCGACAACGGTTGCTG
CGCAACCTGCTCGACCACCGGGTGCGCGCGACCACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166087442.1\|3056377_3056911_-\|ribonuclease-HI	unknown	unknown	gnl\|CDD\|260010
NZ_CP049867.1\|WP_166087422.1\|3039062_3040781_-\|L-lactate-permease	unknown	unknown	gnl\|CDD\|224535
NZ_CP049867.1\|WP_166090188.1\|3051503_3052904_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|132469
NZ_CP049867.1\|WP_166087432.1\|3047713_3048532_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP049867.1\|WP_166087428.1\|3044984_3045413_-\|heme-binding-protein	unknown	unknown	gnl\|CDD\|225734
NZ_CP049867.1\|WP_166087440.1\|3053295_3054807_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_CP049867.1\|WP_166090190.1\|3054803_3056102_-\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NZ_CP049867.1\|WP_166087446.1\|3057012_3058719_-\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|226070
NZ_CP049867.1\|WP_166090181.1\|3035379_3036564_-\|NarK/NasA-family-nitrate-transporter	unknown	unknown	gnl\|CDD\|225133
NZ_CP049867.1\|WP_166087434.1\|3049288_3050344_-\|peptidase-M4-family-protein	unknown	unknown	gnl\|CDD\|225768
NZ_CP049867.1\|WP_166087419.1\|3038223_3039060_-\|calcium-binding-protein	unknown	unknown	gnl\|CDD\|380205
NZ_CP049867.1\|WP_166087426.1\|3043478_3044975_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|183043
NZ_CP049867.1\|WP_166090185.1\|3040829_3042140_-\|glycolate-oxidase-subunit-GlcF	unknown	unknown	gnl\|CDD\|236890
NZ_CP049867.1\|WP_166090183.1\|3036870_3038202_+\|Na+/H+-antiporter-NhaA	unknown	unknown	gnl\|CDD\|184855
NZ_CP049867.1\|WP_166087448.1\|3060453_3061407_-\|succinylglutamate-desuccinylase/aspartoacylase-family-protein	unknown	unknown	gnl\|CDD\|349469
NZ_CP049867.1\|WP_166090192.1\|3058826_3060242_-\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP049867.1\|WP_166087438.1\|3052987_3053299_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166087423.1\|3042210_3043479_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_CP049867.1\|WP_166087437.1\|3050457_3051507_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|132594
NZ_CP049867.1\|WP_166087430.1\|3045409_3047581_-\|malate-synthase-G	unknown	unknown	gnl\|CDD\|235097

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166087442.1\|3056377_3056911_-\|ribonuclease-HI	gnl\|CDD\|260010	cd09278, RNase_HI_prokaryote_like, RNase HI family found mainly in prokaryotes. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD), residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Prokaryotic RNase H varies greatly in domain structures and substrate specificities. Prokaryotes and some single-cell eukaryotes do not require RNase H for viability.	2.9464e-61
NZ_CP049867.1\|WP_166087422.1\|3039062_3040781_-\|L-lactate-permease	gnl\|CDD\|224535	COG1620, LldP, L-lactate permease [Energy production and conversion].	1.05365e-141
NZ_CP049867.1\|WP_166090188.1\|3051503_3052904_-\|amino-acid-permease	gnl\|CDD\|132469	TIGR03428, ureacarb_perm, permease, urea carboxylase system. A number of bacteria obtain nitrogen by biotin- and ATP-dependent urea degradation system distinct from urease. The two characterized proteins of this system are the enzymes urea carboxylase and allophanate hydrolase, but other, uncharacterized proteins co-occur as genes encoded nearby in multiple organisms. This family includes predicted permeases of the amino acid permease family, likely to transport either urea or a compound from which urea is derived. It is found so far only Actinobacteria, whereas a number of other species with the urea carboxylase have an adjacent ABC transporter operon.	1.14474e-58
NZ_CP049867.1\|WP_166087432.1\|3047713_3048532_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	9.4291e-61
NZ_CP049867.1\|WP_166087428.1\|3044984_3045413_-\|heme-binding-protein	gnl\|CDD\|225734	COG3193, GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only].	2.78717e-31
NZ_CP049867.1\|WP_166087440.1\|3053295_3054807_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	2.07182e-73
NZ_CP049867.1\|WP_166090190.1\|3054803_3056102_-\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	2.52107e-55
NZ_CP049867.1\|WP_166087446.1\|3057012_3058719_-\|alkaline-phosphatase	gnl\|CDD\|226070	COG3540, PhoD, Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism].	4.75782e-137
NZ_CP049867.1\|WP_166090181.1\|3035379_3036564_-\|NarK/NasA-family-nitrate-transporter	gnl\|CDD\|225133	COG2223, NarK, Nitrate/nitrite transporter [Inorganic ion transport and metabolism].	7.65866e-80
NZ_CP049867.1\|WP_166087434.1\|3049288_3050344_-\|peptidase-M4-family-protein	gnl\|CDD\|225768	COG3227, LasB, Zinc metalloprotease (elastase) [Amino acid transport and metabolism].	3.83684e-109
NZ_CP049867.1\|WP_166087419.1\|3038223_3039060_-\|calcium-binding-protein	gnl\|CDD\|380205	NF033203, entero_EhxA, enterohemolysin EhxA. Members of this family are the RTX toxin called enterohemolysin or EhxA, because it is found in enterohemorrhagic Escherichia coli (EHEC) strains such as O157:H7.	1.85774e-16
NZ_CP049867.1\|WP_166087426.1\|3043478_3044975_-\|FAD-binding-protein	gnl\|CDD\|183043	PRK11230, PRK11230, glycolate oxidase subunit GlcD; Provisional.	3.87627e-180
NZ_CP049867.1\|WP_166090185.1\|3040829_3042140_-\|glycolate-oxidase-subunit-GlcF	gnl\|CDD\|236890	PRK11274, glcF, glycolate oxidase subunit GlcF.	1.36371e-113
NZ_CP049867.1\|WP_166090183.1\|3036870_3038202_+\|Na+/H+-antiporter-NhaA	gnl\|CDD\|184855	PRK14853, nhaA, pH-dependent sodium/proton antiporter; Provisional.	0
NZ_CP049867.1\|WP_166087448.1\|3060453_3061407_-\|succinylglutamate-desuccinylase/aspartoacylase-family-protein	gnl\|CDD\|349469	cd06251, M14_ASTE_ASPA-like, Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup. A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.	5.84834e-91
NZ_CP049867.1\|WP_166090192.1\|3058826_3060242_-\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.85553e-75
NZ_CP049867.1\|WP_166087423.1\|3042210_3043479_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.30181e-47
NZ_CP049867.1\|WP_166087437.1\|3050457_3051507_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|132594	TIGR03555, 510-methylenetetrahydromethanopterin_reductase, 5,10-methylenetetrahydromethanopterin reductase. Members of this protein family are 5,10-methylenetetrahydromethanopterin reductase, an F420-dependent enzyme of methanogenesis. It is restricted to the Archaea. [Energy metabolism, Methanogenesis].	6.31351e-58
NZ_CP049867.1\|WP_166087430.1\|3045409_3047581_-\|malate-synthase-G	gnl\|CDD\|235097	PRK02999, PRK02999, malate synthase G; Provisional.	0

>NZ_CP049867.1|WP_166087432.1|3047713_3048532_+|IclR-family-transcriptional-regulator
MTTAEPNEQPAGRTGSGPGAREGGGGGVQSVHRAFDLLEVVVARGGSATIGEIAAAADVPLATAHRLLRTLVERGYMRQSPDRRYALGFRLVPLGAAASSMAGAGTEHLLSGLVDALGETANLAMLEGSSVTYVAQVPGRHSMRMFTEVGRRVQPHCTAVGKAMLAEVSDAEAAAVLGRIRLARHTSATVTDLDAVVAGLAEVRRLGYAMDEGEQEVGVRCVAVAVPPAPGSTLRLAVSVSGPEPRMTDDVVARAVPLLQRTAASLSRAIAG
>NZ_CP049867.1|WP_166087430.1|3045409_3047581_-|malate-synthase-G
MAERVQTGGLDVAAPLHRFVEEEALPGTGLESAMFWDGVAAVINDLAPRNAELLAKREDIQGRLDTWHREHPGTPDAGEYTAFLREIGYLLDEPADVAVSTSGVDDEVATIAGPQLVVPLLNARFATNAVNARWGSLYDALYGTDVVPHDGDLAPGDDGYNKTRGDEVIRRGRAFLDEHFALASGSHADATAYTVDDDGLAVTVGDDTVRLADPAQLVGFRGEAATPDAVLLVHHRLHVEIQIDPSDQIGETDKAGVKDLLLESAVSTIMDLEDSVAAVDGEDKALGYRNWMHLMQGTLAEEVTKGGKTFTRSMNPDRVYSTTTGEDVTLRGRSLLFIRQVGHLMTTGAVRDEDGNEVPEGILDAIMTGLGSLKALRGEAELANSREGSMYVVKPKMHGPEEVAFAVELFGRVEELLGLPRLTIKVGIMDEERRTTLNLKACINEARERVVFINTGFLDRTGDEIHTSMQAGPVVRKAAMKGETWIKAYEDLNVDIGLECGLLGRAQIGKGMWAAPDSLADMLEAKIGHPQSGASCAWVPSPTAATVHALHYHQVDVRARQEELAAGGRRRERDDLLQIPLGNPDDWSEQDRQEEIDNNLQSLLGYVVRWVDAGIGCSKVPDITGENLMEDRATCRISAQHVANWLHHGVVTSEQVEETLRRMAKVVDEQNAGDSTYTPMAPDFDGQAFAAAHDLVFEGLTQPSGYTEPILHRRRASKKEQSA
>NZ_CP049867.1|WP_166087428.1|3044984_3045413_-|heme-binding-protein
MSLTLDTARSIIAGARAHGSQAGFKPLTVVVLDSGGHVVAVEREDGASMSRFEIGFGKAYGALSLGMGSRSIMGRAEQQAYFIAAVTSAVGGALVPVPGGVLVRDEGGDLLGAVGVTGDTSDNDEAAAVAGIEGAGLTAQAD
>NZ_CP049867.1|WP_166087426.1|3043478_3044975_-|FAD-binding-protein
MTTTQEPTGVEVSPEIAAVTDAVRGVIPAAGIITDRTRLRTYECDGLAHYRVTPALVVIPEDAAQLATVIRACAAHGVPYVARGSGTGLSGGALPHAEGVLVVTSRMRAITEIRRADQRAVVEPGVINLDVTKAATPEGYYYAPDPSSQQICSIGGNVAENSGGAHCLKYGFTTNHVLGADFVTAEGDTVPLGGLAPDSPGYDLLGAVVGSEGTLGIVTSTTVRLVRLPEEVRTILVGFETTDQAGAATSAIIAAGIVPAAIEMMDALAIEAAEAAVQCNYPDGAGAVLVIELDGASVEVEQEYVEVERLCRENGSFEQRLAVDPAERALIWRGRKSAFAAVGRISPDYIVQDGVIPRTALPEVLHRIAELSEESGVRVANVFHAGDGNLHPLVLFDDAKEGAAEAAEKVSGAILDLCIEHRGSITGEHGVGMDKSKYMPRMYNDEDLDTMQLVRCAFDPQSISNPGKVFPTPRLCGEVPGKRKEAHPLVQAGLADAF
>NZ_CP049867.1|WP_166087423.1|3042210_3043479_-|FAD-binding-oxidoreductase
MTTETLTPTAREAVASACADVRDGSETDAVDGVTPGLVARPADTAQVAEVMKATAAHGLSVVPRGRGTKLSWGTPPSSADVLLDLSGLDEVLDHAAGDLITVARTGTLVADLQQTVAEGGQRLALDETVPGSSIGGTLAADTSGPRRVAVGTARDLLIGLTIVRADGVVAKSGGRVVKNVAGYDLGKLLIGSFGTLGVMTEAVFRLHPLPETRRWVTARVADATGVHDAVQAVVHSQAVPAAVEVEWPTFGEGLVHVLLEGREDGVAGRSTTIEAVLARGALDVSSREEPPAGGATYPWDTDARGDERATAFKLTFALSGLGDVLTAARESGLHVRGSGGVGVAYAALPAGAGVEAAQAALTRVRETCGRHGGAAVVVDAPAEVKAGLDAWGPIPALDLMRRVKDQFDPDHRLAPGRFVGGI
>NZ_CP049867.1|WP_166090185.1|3040829_3042140_-|glycolate-oxidase-subunit-GlcF
MPAPGGAFDEHHPPDAALIGDCVHCGFCLPTCPTYLLWGEEMDSPRGRIYLMKEGLEGEPMTDEMVGHFDACLGCMACVTACPSGVQYDRLIEQTRAQVERNHDRTAPDKALRGLIFSLFPYPKRLKVMRGPLRVMQKTGLDKAMRRTGLLDRMAPQLAAMERLAPPLGKPIPLPERIEATGERRATVGMLVGCVQGAFFPGVNAATARVLQAEGCDIVIPKSQGCCGALSVHNGREPEGQGFARKLIDTFESSGVEYVVVNSAGCGSTMKEYAELLADDPTYADKAKAFADRVRDVAEILHELGPVAPRHPLEMTVAYHDACHLGHAQGIRAQPRDLLRAIPGLELKEIPEAEICCGSAGIYNIINPEPAQQLGDRKAANIVKTGAQVLVTANPGCLMQVTSAIERSGHPMSMAHTVEVLDASIRGVAAANFTSN
>NZ_CP049867.1|WP_166087422.1|3039062_3040781_-|L-lactate-permease
MFQQNPEAVGDSLALSALCAAVPLLTLFILLGGLRMKAWLAGLISLGVSIVIAIVLFGMPVSQTFSATAEGAAFGFFPILWIVINAIWVYNLTVKSGHFDVLRRSFEKVSPDQRIQAIIIAFCFGALLEALAGFGTPVAITVVMLMALGFQPLKAAAVALIANTAPVAYGALATPIVTLASVTSTVNDDPGLTVENLGAMVGRQTPILAIFVPLVLVFVVDGKRGVKQTWLPAIVGGLAFGIGQFIAANYISVPLADIIAALVSALAIVALVRVWSPSQTITAADMRDSDESAGESGGSAVGAGRPGGAGGPGATATKTEPAHADSRADVVKAYAPYLVIVAIFSVINIPAVKEFFAAEPWTFAFTWPGLDILNPSGDPVATIYNFNWFPAAGTLMIFAGIITAAILKVSPGTALKTYGETYVELKSAILTVMAVLALAYVMNLSGQTAALGAWLAGAGTAFAILSPILGWLGVAVTGSDTSANALFGALQVQTAAQAGLDPVLMAAANTSGGVLGKMISPQNLAIAAAAVGMAGKEGDIFRKVVGWSLLLLVFMCALVALQATPVLSWMVP
>NZ_CP049867.1|WP_166087419.1|3038223_3039060_-|calcium-binding-protein
MKARLRPSTAAGLVPAAGAAFLLVLGTVVPVSAGASPVAAPSSAAVSQVALAPAAARKAPAPQRWLQIERTRRGYLVTAGLQHSRMRITETRNGLRIVDPGTAELRERLRSCERVRVRVGIGALCRVSDRVTKRHPMRLGVVPRLGNDLVDARSLPARYNLSVLADAGHDVVRLGDGDDFVNGYTGVDRVFGGRGSDWIRTGIGDDVIKGGRGGDRLVGVEDDDVVRGGAGRDQVGGGPGRDRLYGGDGADAISCGDGRDHAWTERGDTRRDCERLHR
>NZ_CP049867.1|WP_166090183.1|3036870_3038202_+|Na+/H+-antiporter-NhaA
MRRPWRFSPVSREQRHARRTFLGRGSWAETARIAEVLRQETVGGALLLLGTVVALVWINSPAGDSYVALRDLTVGPSALHLDLTLGTWAADGLLAVFFFVVGLELKREFVAGDLRDPKRAALPILAAVGGVVVPAVVYALVTFRTDGALQGWAIPTATDIAFALAVLAIISTHLPSGMRTFLLTLAVVDDLIAVTIIAVFYTSDLALLPLAAALLPLGLFALLVQKRVRSWWLLLPLALVTWVLMHESGVHATVAGVLLGFTVPVIRSRAAGGPDAGPGLAEHFEHRIRPLSAGVAVPVFAFFAAGVEIGGLEGLGDSLADPVALGIVLALVLGKPIGIVGTTYVVARFTRASLDEELSWLDVVGLGLLAGIGFTVSLLIGDLAFGGGGDTDDHVKVGILLGSLVAALLASVLVKTRDRVYRRIWEAENVDDDQDGVPDVYQR
>NZ_CP049867.1|WP_166090181.1|3035379_3036564_-|NarK/NasA-family-nitrate-transporter
MLVVATIGFAVNFWAWALLSPLGPLFRESGSLGALSESDVALMVAVPVVVGSLGRILVGALTDRFGGRVMFPLVSAATTVPILFLAFFALDSYALVLVGGFFLGIGGTAFAVGVPFVNAWFPPERRGLAVGIFGAGMGGTAVSALTTVRLFTDAGEKAPFLITAVALAVYAVVAWLVLRDAPGRSVPTTSLAARLSANARLPITWQACLLYAVAFGGYVAFSVYLPSYLKTDYDLTPADAANRMAGFVVVAVLMRPVGGWLSDRFGAVPVLASGYAVVVVGAGVAATHPLLEHIGTVAFLAMAAALGSGSGATFALVAKVTDPSRVGGVTGLVGAAGGLGGFVPPLVMGYVYGRTDSYAIGLWLLSVTAALTLVLTLTVVRRTELGSTRREVLA
>NZ_CP049867.1|WP_166087434.1|3049288_3050344_-|peptidase-M4-family-protein
MSVNHDARCYFVPPYVQSEVSRNAGGAAADTSQSALSDAARERRDAAAAGPAAAPAPGAALAPAPTGTGRREVYDSAGTTDQRVTLVRYEGSPETKDVDVINAYDNAGIVRAFFGKVLNRNSIDDRGLDLVLNVHFGTAYNNAFWDGDEMTFGDGDGVIFTGFSRSLDVVAHELAHGVTQFTSGLVYEDESGALNEHFSDVFGTAITQWAAKESPAEADWLIGDEIMGPDLFGEALRSMRHPGTAYDNPILGQDPQPAHYADRYTGTADNGGVHINSGIPNRAFYLAATEMGDTVLTSRIWYHALHFLAPRATFAQAATQVAESARILVKAGAVPKGAAQVVRGAWNAVGV
>NZ_CP049867.1|WP_166087437.1|3050457_3051507_-|LLM-class-flavin-dependent-oxidoreductase
MKFSYVMLPDYPLTESLASIRKADELGFHAVYAADETWHKDLWLLFAAAAADTSQIRMGPSVSGVVLREPTLIAQAAATLDELTGGRAEVVLSSGNFGLLAQYGIDWSKTKPLSRVKEGVEVIRTLLDDGVITHEGEFFNYTGLFTFARPVQERLPVKMGAMKGPKSFQVSAEFSDGCHHALSYTREAYDYMIEHCTIGAERAGKNVQDLDLGAWIVFSVAEDSAKAKDAARSMVGLYASSMPHDQLRRNGVEPEEVAPIIEAIGAGDMAKGIELTTPDLAERLSVAGTPEECVEKMQTQIAAAGVNHMILAITDASLVKALMGREIEGVPDVDTQLQLIHDRVMPAFA
>NZ_CP049867.1|WP_166090188.1|3051503_3052904_-|amino-acid-permease
MSMWANFSLGFTYLSPVVATYTLFGIAIVAGGPPMIWWLVIVGVGQFLVALVFGEVVSQYPVAGGVYPWARRLWGRRWAWMTGWVYILALLVTIASVVYGAGPYLAALLGFTAGTGSTIVCALIMLAVALALNMLGTRVLAFAAVVGFTGELLGALAVGGWLLLTERNQDLSILFDTQGVTGEGGGYLAAFFAAAIIGVYQYYGFEACGDVAEEVPDPTREIPKAMRLTIYIGGAASTLVCLSLLLAVKDFGAIINGEDPDPVMTILNDVFGTVGTKLVLVVVMISFLSCTLSLMAAASRLMYSYARDDMIFASHLLRHFDRVRHVPPYAMIVAASVPAVVVLGSVVSTKALTSIVSFAILGIYLAFQMVVLAALRARLKGWVPSGPFTLGVWGLPVTVAALAYGVLTMINVAWPRTPDVPWYDNWVVALSALVGIGVGLVYMLVAKPYLRSEATSGDAIPTKEER
>NZ_CP049867.1|WP_166087438.1|3052987_3053299_-|hypothetical-protein
MSDAHDRTPIGYRYAEQVTPPEPQRVSDVAITTHEHVYEVDPRLMERWVLQQQFPNWDSLRIMNSRGDHLEWMHRHFAHTVVTGSELLAEVDAEGAGTDGADR
>NZ_CP049867.1|WP_166087440.1|3053295_3054807_-|FAD-binding-oxidoreductase
MTVTVEALDELVTALRTVLADDQILTSKTDRYNRARVPAPFPVHRWSERLPDLAVLPTSTEQVAGVVRIANELRVPVVPRDGGTGLTDGAVPLRGGIVVDVKRMNQVKELDLENRTVTVGTGISMLKLNEQLAKHDLFYPDDPASYPCSLVGGRIGTSGWSLIGSRYGHSRDLVLSFDHVLPTGEVMHVGDGIGHKISKSSSGYQLKHLFMGHQGTLGIATEATLKLFPKPEAELSPFWAFDNYDDAYRCVGALARAGVATFAGAVLFDEWKVAYLRRDDEAYIPQPNDVRALVCAVMYGYEDEVRPAGKRLFRIAKDHGARYLGDEISEGDWAARHDRYATPLHGRTKAGQVVPMSWHCEDAAVNYTNLPSVSRAWHEIVADLRRRTDVFDDWGMFTYTSGSTGVDYLTEIDVGIWEQQLDDRAWEMWVKAKRDIAAVALAHNGSISACHGSCREGEVDLVPQELGRGFDVMLDLKRTLDPNNIMNPGKYLLDRAYETGPHA
>NZ_CP049867.1|WP_166090190.1|3054803_3056102_-|(Fe-S)-binding-protein
MRDNPDELAQFGDEIARDPEVKHDPTPTEEFTEEWRNASYNCFSSGHKFCREVCPVMQVTRNESWTPTAFHANVVAMDKGELSIEEVAGDYVNCTQCGACELRCPNTLFTGDFYRFRTRTVDVVKAVRAFAVESGIHQPAWKTWNARTDDKTHEPVLGEIPIKQENVRDWSAGLDIPIGGESVLFVDCEAAYYRTSVPRAVAQILQLAGYEFGLMGEQWCCGGPAAEMGYVDQAQRFARHNLDNWRSTGTKRILVLDPHDYISFTEDYPKYFGEEFDLEVVLVVELFAELIREGRLTPSVPVERAITYHDPCRLNKRKGVWKEPREILRSIPGLDFSDVDRVTQWSYCSGGGGGLPVEKPELTAAISASRLEKAAALEVDTLVSACPWSERPLSAAGEAVDIDVVDIHELLAASLGIEVGGTTNGSANGSAR
>NZ_CP049867.1|WP_166087442.1|3056377_3056911_-|ribonuclease-HI
MTIIAAADGSALGNPGPAGWGWYVDDACWAAGGWAHGTNNKAELTAVLDLLQQTAHLDDDLLVYCDSTYVINSVTKWMAGWKRRGWKKGDGQPVLNVEIMQALDAAMAGRRVKFAWVKGHSGHPLNEAADKLANAAATSWKGGSAPAPGPGFEGAVTTAVVEQPKRVYDDADLFSGL
>NZ_CP049867.1|WP_166087446.1|3057012_3058719_-|alkaline-phosphatase
MTPRAETPTEPAETAVPAGPRIPRRGLLAAGASVAAAASLSTAARATTTASERVFRHGVASGDPLPTAVVLWTRVTPRAAATPGSGVGPRVEVVWEVAEDRDFSRVVRRGRVATGPKRDHTVKVDADRLAPGRWYFYRFRLDGVTSPVGRTRTAPAASAAPDRLRLGVVSCSQLTDGFFAAYRHLADRDDLDAVLHLGDYLYEGGNGDDDVRPHVPAREIVSLADYRRRHAQYKTDPDLQRLHGRYPFIVTWDDHEVTNDSWRAGAENHQPDEGDYLKRKARAQRVYDEWMPVRLSGTAATGDGTRLFRRLTWGTLADLNLLDLRSYRDEMVTTAAPFPLPQIQDEADDPDRTITGNRQMAWLKDSLLRDHAQWKLIGNSVMIAPLSFAQLPRDAVEAINAVTGEGPADGVPLNLDQWDGYTADRRELIAHLDDNGITDTVFLTGDIHSAWANDLPLDTGTYPATRSVAVEMVCTSVTSSNIDEETGAPPRTATLAIEATLQANNRHVKYLNFDDHGYSVLDVDRERAQMDYFVLADKRRRDSAAHRTASWLTRSGSQQVESTTTPLA
>NZ_CP049867.1|WP_166090192.1|3058826_3060242_-|multidrug-efflux-MFS-transporter
MLRWLVLATFIVILNETIMVNAIPRLMVEFDVTARDAQWLSTAFMLTMATVIPVTGWFLQRVTTRTAFTVAMATFMTGTLVSALAPVFWLLVSGRVVQAAGTAVMVPLLMTTLMTVVPEHDRGRVMGNVTLAISVAPALGPTISGIVLQWTSWRWLFGLVLPVAAVITVLALRRLKNVGETKPGAIDWLSVVLAGLGFGGLVYGLSGLGEGAASAVPPVALVAAGLVLIGLFALRQRSLQKRDAPLLDLRTLAHRTFTLSLSLQAVSFLAMLGAMILLPLYLQDVRGLSPLQTGLMVAPGGIAMGLLGPSVGCAFDRFGGRPLVVPGSVGIVAALVVMSRVGETTPYAVIVGAHLLLMVSLAATFTPAFTLGLGALPAHLYSHGSSLLGTAQQVAAAVGTAVAITVLSSRAADLATEGASPDAAFVGGMQTAFTAAAGIALLAVVFAVLLPSRVPTQPGVDAAAEPVAAPA
>NZ_CP049867.1|WP_166087448.1|3060453_3061407_-|succinylglutamate-desuccinylase/aspartoacylase-family-protein
MARPSFEIGSVRVRPGRHQALSLPITRLVTGADVDLPVRVVHGREDGPTVWIDAAIHGDEAVGVEVVRQVLADLDPKTLRGTLIAVPIVNVLGFMNGSRYLPDRRDLNRSFPGSARGSLAGRIAHLMTTEIIDKCEVGIDLHTGSDRRSNLPQIRTDLEDPRTRELAAAFAAPVMMHAKLRDGSLRSAARERGAKVLLYEAGEAWRMDQWAIDAGVRGVRRVLAAMEMVEPLAEEPPAPSAVSWRSGWVRARGTGMLHLEVDLGERVEKGGRLGGLFDSFGKRVRLVHADRPGIVVGRTEAPLVNSGDAVVHIAEVE

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Crispr_ID: NZ_CP049867_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_13

3206812-3206896

Orphan

Consensus_repeat	Method
CGGTTTCACTAGGTACCTAGTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_13

>merge|NZ_CP049867|13|3206812-3206896|CRISPRCasFinder
CGGTTTCACTAGGTACCTAGTGATCCTGGCGCTTCCCGAGCGAAGTTTCGTGCGGGAAGCGCCGGTTTCACTAGGTACCTAGTGA

>NZ_CP049867|13|13|3206812-3206896|CRISPRCasFinder
CGGTTTCACTAGGTACCTAGTGA	TCCTGGCGCTTCCCGAGCGAAGTTTCGTGCGGGAAGCGC
CGGTTTCACTAGGTACCTAGTGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166087701.1\|3208655_3209684_-\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274647
NZ_CP049867.1\|WP_166090235.1\|3212092_3212854_-\|phosphotransferase	unknown	unknown	gnl\|CDD\|225547
NZ_CP049867.1\|WP_166087703.1\|3210557_3211439_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225663
NZ_CP049867.1\|WP_166087711.1\|3213739_3214573_-\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225758
NZ_CP049867.1\|WP_166087699.1\|3207495_3208656_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173849
NZ_CP049867.1\|WP_166087681.1\|3199351_3199639_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166087679.1\|3197179_3198181_+\|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase	unknown	unknown	gnl\|CDD\|274635
NZ_CP049867.1\|WP_166090232.1\|3198236_3199187_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166087713.1\|3214582_3215266_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NZ_CP049867.1\|WP_166087683.1\|3199781_3200072_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166087692.1\|3204701_3205610_-\|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	unknown	unknown	gnl\|CDD\|274584
NZ_CP049867.1\|WP_166087694.1\|3205667_3206765_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166087705.1\|3211600_3211948_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166087690.1\|3202812_3204606_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377286
NZ_CP049867.1\|WP_166087696.1\|3206914_3207322_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166087709.1\|3213327_3213732_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239517
NZ_CP049867.1\|WP_166087685.1\|3200075_3201371_-\|succinyldiaminopimelate-transaminase	unknown	unknown	gnl\|CDD\|236119
NZ_CP049867.1\|WP_166087707.1\|3212850_3213318_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224931
NZ_CP049867.1\|WP_166087687.1\|3201719_3202766_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP049867.1\|WP_166087677.1\|3195998_3197090_-\|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl\|CDD\|237264

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166090235.1\|3212092_3212854_-\|phosphotransferase	gnl\|CDD\|225547	COG3001, COG3001, Uncharacterized protein conserved in bacteria [Function unknown].	1.92314e-47
NZ_CP049867.1\|WP_166087711.1\|3213739_3214573_-\|MOSC-domain-containing-protein	gnl\|CDD\|225758	COG3217, COG3217, Uncharacterized Fe-S protein [General function prediction only].	5.01348e-43
NZ_CP049867.1\|WP_166087692.1\|3204701_3205610_-\|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	gnl\|CDD\|274584	TIGR03445, mycothiol_MshB, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase. Members of this protein family are N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, also called 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, the MshB protein of mycothiol biosynthesis in Mycobacterium tuberculosis and related species. [Cellular processes, Detoxification].	9.35298e-121
NZ_CP049867.1\|WP_166087687.1\|3201719_3202766_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.57911e-14
NZ_CP049867.1\|WP_166087685.1\|3200075_3201371_-\|succinyldiaminopimelate-transaminase	gnl\|CDD\|236119	PRK07865, PRK07865, N-succinyldiaminopimelate aminotransferase; Reviewed.	0
NZ_CP049867.1\|WP_166087713.1\|3214582_3215266_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	6.09241e-10
NZ_CP049867.1\|WP_166087699.1\|3207495_3208656_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	0
NZ_CP049867.1\|WP_166087703.1\|3210557_3211439_+\|hypothetical-protein	gnl\|CDD\|225663	COG3121, FimC, P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion].	0.00237659
NZ_CP049867.1\|WP_166087690.1\|3202812_3204606_-\|hypothetical-protein	gnl\|CDD\|377286	pfam04294, VanW, VanW like protein. Family members include vancomycin resistance protein W (VanW). Genes encoding members of this family have been found in vancomycin resistance gene clusters vanB and vanG. The function of VanW is unknown.	1.03997e-62
NZ_CP049867.1\|WP_166087701.1\|3208655_3209684_-\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274647	TIGR03559, F420_Rv3520c, probable F420-dependent oxidoreductase, Rv3520c family. Members of this protein family are predicted to be oxidoreductases dependent on coenzyme F420. The family includes a single member in Mycobacterium tuberculosis (Rv3520c/MT3621) but four in Mycobacterium smegmatis. Prediction that this family is F420-dependent is based primarily on Partial Phylogenetic Profiling vs. F420 biosynthesis. [Unknown function, Enzymes of unknown specificity].	1.91895e-169
NZ_CP049867.1\|WP_166087709.1\|3213327_3213732_-\|NUDIX-domain-containing-protein	gnl\|CDD\|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	2.63512e-32
NZ_CP049867.1\|WP_166087707.1\|3212850_3213318_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	gnl\|CDD\|224931	COG2020, STE14, Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones].	2.23991e-15
NZ_CP049867.1\|WP_166087679.1\|3197179_3198181_+\|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase	gnl\|CDD\|274635	TIGR03535, DapD_actino, 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. This enzyme is part of the diaminopimelate pathway of lysine biosynthesis. This model represents a clade of the enzyme specific to Actinobacteria. Alternate name: tetrahydrodipicolinate N-succinyltransferase.	9.85142e-169
NZ_CP049867.1\|WP_166087677.1\|3195998_3197090_-\|succinyl-diaminopimelate-desuccinylase	gnl\|CDD\|237264	PRK13007, PRK13007, succinyl-diaminopimelate desuccinylase; Reviewed.	0

>NZ_CP049867.1|WP_166087694.1|3205667_3206765_+|hypothetical-protein
MTSPSRSAPTLVPGLAADDAIDALVEASGGRVGLTGVLGHLNRVAEPAWGPGSAVSHAFAWDEADQRSRRWWPQGVTSSSEARLPRGDPWPGPPVLLTTSYAKKVGGLDKGSRITVADLGDPDRVRYRHVLLVRAVRDDTGAVDLRPVKAHAGGVVWHGPWLYVAATRRGVLAFRLDDVVRVSPAPPDRLGRHEDGDGLAGFGHGYALPLHHVLGPPEPSDGEAATPPAMRYSFLSLARGLDGRTALLAGEYDAGGGTRRLVVFDLDATGAPVTDPSGVAASTHVADGVDRMQGAVWLPDGRLAVTASDGRYRRGHLWVGAPGALERRRSAVPVGPEDLTSWPERGELWTATEYPGHRLAVALHL
>NZ_CP049867.1|WP_166087692.1|3204701_3205610_-|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase
MESPEQRLLLVHAHPDDESINNGATMARYVAEGRGVTLVTCTLGEEGEVLVPDLAHLAADKEDGLGAHRVGELEAAMKEVGVTDHRFLGGPGHYRDSGMEWDETGHAKPAETDRTDIFWRADLTEAAHLLVEVIREVRPQVLVTYDEFGNYGHPDHIQAHRVAMYAAQLAAVPHYRLDLGEPWDVAKIYWTAMSLSKMREGARMMKENGIENPFSDMDYDNPPRFMVPDEAIACEVDGTAYAEQKMAAMAAHATQIEVDGPFFALSNNLGNQVWGTEVYRLAKGTKGPVDERGWESDLFAGL
>NZ_CP049867.1|WP_166087690.1|3202812_3204606_-|hypothetical-protein
MTSGPTSWLDDRADDPDRPDDADDAREQERERSRRRRDRRILVWLTVAVAVIVGGFYLAGYVLASDRLPRATTVAGVDVGGLKPQAAAAELRRGLADAQRRPLVVAASDREFALDPEEVGLEVDAAASVEQVPVGRSWHPADIWESFVGGEDYDPVVVTIDDLLEQRLEEVAGRVDVAPVEGDVEFGDGRARPVYPEPGRRLDVSAAVAQVVASFPTREVVPLPVRNARPELSARQVSEAMRDFANPAMSASVVYSFGPRDVTVRPAQFADALSMEVDDGELVPRVDEDRLLRLFGPATRSVAREPVDATVAIRDGRPEVVPGRRGATIDRDRIVEVLPDLLTGTGADRRARIDPRPVDPAISTAEARDWQIREKVSEFPTYYPHEDYRNTNIGRAAELIDGTVLAPGDTFSLNETVGERTRANGFTEGFIISDGVFKSELGGGVSQVATTTYNAAFFAGLEDVEHKPHSFYIDRYPMGREATVAFPVVDLKFRNDTDYGVLIQAIHSPSAPGGTGGLTVRMWSTKVWDIESVTSGQYDFTSPDTRYGSGEDCVPNEGYGGFTVDVTRIFREPGSSEVVKREKDTTVYTPSDTVICE
>NZ_CP049867.1|WP_166087687.1|3201719_3202766_+|GNAT-family-N-acetyltransferase
MPLPTALGPACLGLRVVVRRVLPGETGPSGGPAMTDVLGVLESWEDDALTVRREDGSVVRVDRSTLVSGKAVPPRASVRHRVPAEVAARRALGSWPAVEAEPLGDWVLRASGGFSARANSVFLTGDPGMPWDEAVARARAFYAERDLPAWAQVVVGSPEDLRADAEGWHQARPGEADSLLQVASVAQAVRQAREFRSQERSDPPRDGVDGDLNVLVNEMFVREEMTDGWLATDERARERPEASRAVLEGPDHVAFVTLEVDGAVVARARAAMPDSDDWVGLTDVWVDPERRRGGLARSVVGALMPWAAERGASTAYLQVRADNAAGLALYQRFGFVTHHAYRYLRLPD
>NZ_CP049867.1|WP_166087685.1|3200075_3201371_-|succinyldiaminopimelate-transaminase
MEGLLQGQRGVLRRPRLSRRRRQDGRHREGPPRRRRAAPAGARRVTSGSSNDSTVPSPGAPRWAARPVSGRLPDFPWDALVPMGDRARAHPDGIVDLSVGTPVDPTPAVVRQALADASDSPGYPLTIGTPALRASIVGWLERRAGAVGLEPRQVLPSVGSKELIAGLATHLGLGPGDLVVAPRLAYPTYTVGAALAGARVVAADALTSLGPESPTLVWINSPSNPTGQVLPVEHLRKVVAWCRERGALLVSDECYLESGWDAEPVSVLHPDVCDGDVTGILTVHSLSKRSNLAGYRCAFVAGDPTVVAELTAVRKNLGLMLPGPMQVAMAAALDDDAHVAEQRERYAARRTALRDALLGAGFTVDHSQGALYLWATRDEPCWDTVAWLADRGILVAPGDFYGTAGTRHVRVAITATDERVGAAVARLGRPA
>NZ_CP049867.1|WP_166087683.1|3199781_3200072_+|hypothetical-protein
MQTSMLYTMGMALDRAAEHGHPVRLLVEGAWLDGSIAAVDSLGVVLETAQGHHSVVRLERVAAVSVASESPLRAPIARTPYREETVVRPMPGARTA
>NZ_CP049867.1|WP_166087681.1|3199351_3199639_+|hypothetical-protein
MGSTSMMYTMGMALDRAADGGHPVSILVEGSWVDGQIAAVDSMGVVLEGNDGDHTVIRVDRVAAVKVHAESPFRTSISRAPAAPEARPMPGPRTA
>NZ_CP049867.1|WP_166090232.1|3198236_3199187_+|hypothetical-protein
MLAVVVVVVLGVALAVRLGAGPFPDSEVCRAEVGDVTAELSGEQAENASLIAGIGVRRGLPARAVSIALATAFQESKLENLEGGDRDSLGLFQQRPSQGWGSAEQISDPVYATNAFYDGLVEIEGYEDMRITEAAQAVQRSGFPEAYEEHAEGARALASALTGYSPGAFSCVVRHGDLEAEEPGERGLTARAEAAVVDVERVFGELPLGGFSPEGVTTGHMEGSAHYAGRAVDVFFRPVNDANLRRGWAVAQYLVANAERLGVDHVIFDDRIWSSGLRSEQGWRDYDAPVESSTAPATRVILEHRDHVHLDVVEGG
>NZ_CP049867.1|WP_166087679.1|3197179_3198181_+|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase
MSTPSSGPSATPSSTSSTPAVEAHGSALVTRVAGGEGTVLDAWFPAPALGAPAAGHAAPAELASLAGEDEVRGVVREVVEVHVTDLQSPPTDTVDAWLRLHLLSHRLVRPHGVNLDGVFGLLTNVVWTSVGPCAVEGFEQTRLRLRAAGHHVTVLGVDKFPRMTDYVLPSGVRVADADRVRLGAHLASGTTVMHEGFVNFNAGTLGSSMVEGRISAGVVVGDGSDVGGGSSIMGTLSGGGTQVISVGERCLLGANAGLGITLGDDCVVEAGLYVTAGTKVLVHEGDGTRVAKARELSGASNVLFRRNSTTGAVEAVPWKGDGIALNAALHAND
>NZ_CP049867.1|WP_166087677.1|3195998_3197090_-|succinyl-diaminopimelate-desuccinylase
MSPATPLSDHLADAVGDPLELTRRLVDIPSVSGDEQAIADAVEGLLRRYPHLEVERFGHTVVARTQLGRADRVVLAGHLDTVPEHDNLPSRLEDGILHGLGTCDMKGGVAVGLHLAATVTDPPRDVTYLFYECEEVEAERNGLTKLAAARPDLLEADFAVLMEPSNAVVEAGCQGTMRVEVTLTGQRAHSARSWMGSNAIHAAAPVLEKLAAFEARRPVIDGLEYREGLNAVGIAGGVAGNVVPDTCVVSVNYRFAPDRSEEEALAFLTDLFAPHLVQVKDSSPGALPGLGVPAARDFVTAVGGEANPKFGWTDVARFSGLGVPAVNFGPGDPMYAHRQDEHVPVEHVARVAAQLRAWLAGTS
>NZ_CP049867.1|WP_166087696.1|3206914_3207322_-|hypothetical-protein
MEIAQYHKMRRAVQVNASPGSAQELRAVQSDLRTALASVGLFEEVEVEYTDDLDQLVIAMFTFPEQLSRSEVARRLELMWEDRLRYPFWEAHSLLVDKDQIEFQGATRAGSNGHYVTVHIVAQQARVPAQRVAAD
>NZ_CP049867.1|WP_166087699.1|3207495_3208656_-|acyl-CoA-dehydrogenase
MTAATQEKRDLFTEEHESFRQTVRTFMEREVVPHHKQWEADGVVSREVWRKAGEQGLLCFDVAEEYGGAGVSDFRYNQVMAEESARAGASGPGFIVHTDIIVPYLSSLGTEEQKQRWLPGCVSGELITAIAMTEPGAGSDLQGIRTTAVDKGDHYVVNGSKTFISNGILSDLVVVVVRTDPEAGHQGISLLVVERGMEGFERGRNLEKVGLKAQDTAELFFDNVVVPKENLLGEEGQGFIYLMMNLPQERLSIAMMAAAACQQVLAMSMAYAKERTAFGKPIGVFQHNRFLIAEMATETEVCQVYVDDCVRRHNEGRLDAVGAAMAKWWTTELQTKIVDRGVQLHGGYGYMLEYPIAQAFLDSRIQTIYGGTTEIQKEIIGRSLGF
>NZ_CP049867.1|WP_166087701.1|3208655_3209684_-|LLM-class-F420-dependent-oxidoreductase
MKLSTPLMYDGNPRNAADQVVAWEKAGLDTVWVAEAYGFDSPTLMGYLAAKTETVEIGSAILNIYSRTPALIAQTAAGLDNISGGRAILGLGASGPQVIEGWHGLPYEKPLGRTREVVDLVRRALKREKLENDGIIKLPLPEGQGTGLGKPLKMLTKPERDTIPIWIASLGQKNVAATAEYADGWLPHLYAPELAEKVWGDSLATGAAKRSAELGPLQIAAGGMVSIGEDVKGMLDFARPMFALYIGGMGAKGKNFYNDLCVQYGYEKEAELIQDLYLDGKKDEAAAAVPEDLLEMCNLVGPESYIKERIAAFQASGVTHLNVVPASEDPAKTISQLKEWIS
>NZ_CP049867.1|WP_166087703.1|3210557_3211439_+|hypothetical-protein
MGLGGRLGERLGGRHLVTALVLVVLLTSAGCTTQEASDETSAVRAPRLTLGLTQLIPEEGTDQALLRVTNDGDEPLLVTAVGLDWAGYGPAFAVPNDATVAPGQTLDLRTTLPEPVCDDRSPEPAAGVLDTSTGRVVVPLKDLSQDYLRRLWRTQCDARLVAEALSVDFEGGWSQEGVGDDASTASTLVLTRRSGDEPLEVRRVDGSVLYDLALDAPLRVAPGEAGGRTTVRILPGNRCDEHARGQATAPFDFELGLVVGDRRVTVPFPVSTATSNAAQTMLDRVCGRVTTAG
>NZ_CP049867.1|WP_166087705.1|3211600_3211948_-|hypothetical-protein
MNRTISRLGATAAASLAVFAFATPAAHAGKPTFNDNTDCGNYCPNPGFPSGNGQGKAPHLAGSQGNADDKNPPGQAPDESDGNQGYECDGNQGIALGNPAHSACEPYTPPPPPPS
>NZ_CP049867.1|WP_166090235.1|3212092_3212854_-|phosphotransferase
MTFRKADPTAPPGYFAWEAAGLEWLRAADGARVVEVDARSDGHLDLERLVPVSPTREAARSFGRALAATHDAGADAWGSPPAGWTGAGFFGPLSQPLPLPLGAWATWGAFSAEARLAPMVARCRDAGLYDAGEVVVLERLVQRVAGGELDTDDRPARIHGDLWSGNVMWTADGVVLIDPAAHGGHRETDLALLALFGAPHLDALLAGYDEAHPPAAGRSERVGVHQLHCLLVHAVLFGGGYGAQAYGIARRWA
>NZ_CP049867.1|WP_166087707.1|3212850_3213318_-|isoprenylcysteine-carboxylmethyltransferase-family-protein
MAHTTRGFPVPPPVLGLAAALAQRALVPRPRPSAPRRAVAVAVAAASAGLAGSAAGGFRRRGTTVNPIRLGESTELVVDGPFAHTRNPMYVGMAGVLTAHAVWRGRPAAALPLLAWVAVIDNLQIPPEEASMAELFGDRYASYRSTVPRWVGPVR
>NZ_CP049867.1|WP_166087709.1|3213327_3213732_-|NUDIX-domain-containing-protein
MTRTLVVGAALLRDGTVLAARRTSPPAAAGRWELPGGKVEPGESPEAAVVRELREELGVEARVVGWLAGEQPIGDSLLLRVAVCATDDEPRPLEHDRVRALGADELGDVDWLEPDRPFLPELRRRLLAGEAPEA
>NZ_CP049867.1|WP_166087711.1|3213739_3214573_-|MOSC-domain-containing-protein
MQVTRLTTYPVKSMAGTRTDHAVVTPQGLHEDRRWALVDPDGRPVTARECHALLGVTAEPTGDGAVRLVTREGAECLLPTVAPDAPTVEVGFSRVSRLALGDAGASTWLSDLVGRPLRFVRLADPSAREIGASHGGRPGESMSLADAGPILLVSQTSVQRLRDWVLEESQEEWLDPEEAVERFRPNVVVDGEEPFAEDGWQRLRIGGTTYRQGELCDRCVMTTIALDSLETTAEPIRTLARHRRWDATTWFGVRLVPELGAEGPAAEVRVGDTVAPL
>NZ_CP049867.1|WP_166087713.1|3214582_3215266_-|phosphatase-PAP2-family-protein
MSPLTTPPREPGTVVRPEPVGGGRARTVAAWATALVAAASVGGVYLLAVLTPTGQHVDDRLMTWAATTVEDTGWAARLLGEVGQVPLLLLVTGAVAALAGAVHGPWRAVVVAAVAATTVVVSQVLKAGLERPSLLDATMMNSFPSGHVAAVAGVAAALVLAVPRVLRAPTLLVTLPVVGAVGLATVVLAWHRPSDVVASVLIAVACAGLGEALVPSRRRPARTAPAL

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Crispr_ID: NZ_CP049867_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_14

3261571-3261655

Orphan

Consensus_repeat	Method
CGTCGGTTTCACTAGGTACCTAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_14

>merge|NZ_CP049867|14|3261571-3261655|CRISPRCasFinder
CGTCGGTTTCACTAGGTACCTAGCGAAACCGGCGCTTCCCGAGCGATGTTTCGCTCGGGAAGCGTCGGTTTCACTAGGTACCCAG

>NZ_CP049867|14|14|3261571-3261655|CRISPRCasFinder
CGTCGGTTTCACTAGGTACCTAG	CGAAACCGGCGCTTCCCGAGCGATGTTTCGCTCGGGAAG
CGTCGGTTTCACTAGGTACCCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166087805.1\|3261700_3262609_+\|DUF2236-domain-containing-protein	unknown	unknown	gnl\|CDD\|378343
NZ_CP049867.1\|WP_166087795.1\|3257587_3257935_+\|nitrite-reductase-small-subunit-NirD	unknown	unknown	gnl\|CDD\|239605
NZ_CP049867.1\|WP_166087824.1\|3269370_3270906_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NZ_CP049867.1\|WP_166090244.1\|3258012_3259131_+\|uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|235981
NZ_CP049867.1\|WP_166087818.1\|3266502_3267048_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP049867.1\|WP_166087814.1\|3264480_3265044_+\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NZ_CP049867.1\|WP_166090242.1\|3253431_3254916_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224171
NZ_CP049867.1\|WP_166087816.1\|3265074_3266418_-\|threonine-ammonia-lyase	unknown	unknown	gnl\|CDD\|236182
NZ_CP049867.1\|WP_166087801.1\|3260402_3261011_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP049867.1\|WP_166087789.1\|3249728_3251225_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|184994
NZ_CP049867.1\|WP_166087810.1\|3263008_3263884_-\|mycothiol-conjugate-amidase-Mca	unknown	unknown	gnl\|CDD\|132487
NZ_CP049867.1\|WP_166087793.1\|3254957_3257591_+\|nitrite-reductase-large-subunit	unknown	unknown	gnl\|CDD\|184951
NZ_CP049867.1\|WP_166087799.1\|3259998_3260388_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NZ_CP049867.1\|WP_166087808.1\|3262688_3263012_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166087797.1\|3259127_3259832_+\|sirohydrochlorin-chelatase	unknown	unknown	gnl\|CDD\|225049
NZ_CP049867.1\|WP_166087822.1\|3268631_3269279_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NZ_CP049867.1\|WP_166087820.1\|3267044_3268598_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP049867.1\|WP_166087812.1\|3263969_3264404_+\|DUF4307-domain-containing-protein	unknown	unknown	gnl\|CDD\|379491
NZ_CP049867.1\|WP_166087791.1\|3251224_3253327_+\|molybdopterin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|239155
NZ_CP049867.1\|WP_166087803.1\|3261133_3261565_+\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166087805.1\|3261700_3262609_+\|DUF2236-domain-containing-protein	gnl\|CDD\|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	6.00374e-50
NZ_CP049867.1\|WP_166087795.1\|3257587_3257935_+\|nitrite-reductase-small-subunit-NirD	gnl\|CDD\|239605	cd03529, Rieske_NirD, Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while fungal proteins have a C-terminal Rieske domain in addition to several other domains. The fungal NirD is involved in nutrient acquisition, functioning at the soil/fungus interface to control nutrient exchange between the fungus and the host plant. The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The Rieske [2Fe-2S] cluster is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs. In this family, only a few members contain these residues. Other members may have lost the ability to bind the Rieske [2Fe-2S] cluster.	1.32926e-45
NZ_CP049867.1\|WP_166087824.1\|3269370_3270906_+\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	8.8201e-73
NZ_CP049867.1\|WP_166090244.1\|3258012_3259131_+\|uroporphyrinogen-III-synthase	gnl\|CDD\|235981	PRK07239, PRK07239, bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated.	3.96868e-149
NZ_CP049867.1\|WP_166087818.1\|3266502_3267048_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	6.87734e-14
NZ_CP049867.1\|WP_166087814.1\|3264480_3265044_+\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	9.56076e-59
NZ_CP049867.1\|WP_166090242.1\|3253431_3254916_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224171	COG1251, NirB, NAD(P)H-nitrite reductase [Energy production and conversion].	2.19278e-104
NZ_CP049867.1\|WP_166087816.1\|3265074_3266418_-\|threonine-ammonia-lyase	gnl\|CDD\|236182	PRK08198, PRK08198, threonine dehydratase; Provisional.	0
NZ_CP049867.1\|WP_166087801.1\|3260402_3261011_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	6.34181e-14
NZ_CP049867.1\|WP_166087789.1\|3249728_3251225_+\|MFS-transporter	gnl\|CDD\|184994	PRK15034, PRK15034, nitrate/nitrite transport protein NarU; Provisional.	6.20149e-107
NZ_CP049867.1\|WP_166087810.1\|3263008_3263884_-\|mycothiol-conjugate-amidase-Mca	gnl\|CDD\|132487	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca. Mycobacterium tuberculosis, Corynebacterium glutamicum, and related species use the thiol mycothiol in place of glutathione. This enzyme, homologous to the (dispensible) MshB enzyme of mycothiol biosynthesis, is described as an amidase that acts on conjugates to mycothiol. It is a detoxification enzyme. [Cellular processes, Detoxification].	1.42568e-175
NZ_CP049867.1\|WP_166087793.1\|3254957_3257591_+\|nitrite-reductase-large-subunit	gnl\|CDD\|184951	PRK14989, PRK14989, nitrite reductase subunit NirD; Provisional.	0
NZ_CP049867.1\|WP_166087799.1\|3259998_3260388_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	6.49756e-36
NZ_CP049867.1\|WP_166087797.1\|3259127_3259832_+\|sirohydrochlorin-chelatase	gnl\|CDD\|225049	COG2138, COG2138, Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism].	9.17949e-21
NZ_CP049867.1\|WP_166087822.1\|3268631_3269279_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	9.92747e-10
NZ_CP049867.1\|WP_166087820.1\|3267044_3268598_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.2788e-76
NZ_CP049867.1\|WP_166087812.1\|3263969_3264404_+\|DUF4307-domain-containing-protein	gnl\|CDD\|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	2.29152e-17
NZ_CP049867.1\|WP_166087791.1\|3251224_3253327_+\|molybdopterin-oxidoreductase-family-protein	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NZ_CP049867.1\|WP_166087803.1\|3261133_3261565_+\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	3.67887e-63

>NZ_CP049867.1|WP_166087803.1|3261133_3261565_+|organic-hydroperoxide-resistance-protein
MTNTPEKIVYTARATVTGGREGRAVSEDGILDLSLTAPKEVGGPGTGTNPEQLFAVGYGACFQGALTMVAKKHGVDASGSELEISVGFGPEGESFAITADIVARIPGVDDAKAQELVDAAHQVCPYSKATRGNVPVTVTGKAA
>NZ_CP049867.1|WP_166087801.1|3260402_3261011_+|class-I-SAM-dependent-methyltransferase
MDAHAWDERYAAAAQVWSTTPNQFVEAALRDLPPGDALDLAAGEGRNAIWLAARGWRVTAADFSAVAVDRGRRLAGDLAIEWRVGDVLVADLPAVDLVVVAYLHLAADERTAVVRRAWSVLRPSGTFFLVAHDLTNLTEGTGGPQDASVLSTAGDVVGDLADEPGVEVVRAERVARLVTADDAHGGEEQHTAWDHVVHLRRS
>NZ_CP049867.1|WP_166087799.1|3259998_3260388_+|thioredoxin
MATTTLTANDFESTVLENDIVLVDFWASWCGPCRQFAPTFEKASEAHTDVVFGKVDTEAEQSLAQAASISSIPTLMAFREGILVFSQPGALPPAGLEQVITAVKDLDMDEVRSQIAAQDTAGPEGGQPA
>NZ_CP049867.1|WP_166087797.1|3259127_3259832_+|sirohydrochlorin-chelatase
MSVPAAGSATVAGAHGAEAPRLVTVAHGTRRPGGNETARRITEAAGRRLGRPATTAYVELSDPLLTDVVAALDGPAVVVPLLLSTGFHVREDLPAMCAGADVVLGRPLGPDALLARAQVARLQEAGAAPGSRVVLVAAGSRDPAAGEDLCAAVGLLAEHWDGEVVAATLSGLGERPEAVLRPGDAVSPYLLSPGLFSRDVEEAARAAGASACADVLGDHPLVVDLVVERTLQLR
>NZ_CP049867.1|WP_166090244.1|3258012_3259131_+|uroporphyrinogen-III-synthase
MAGGPLSGFRIGVTAARKVEEQIALLERRGAEVEWAPALSLDPNRVDDSELRPATEAVIADPPDMFLVTTGIGMRAWLDAAAGWGLRDDLVAALGKAEILARGPKSVGALRGAGLRELWAPASELFEDVLDHLRGRDLGGMRIVVQEHGQSLSMVAHALRRQGATVDVVTVYRVAGAEDPQPMFRLVDHVAEGALDAITFTSAPAVAALMDAAASVGRRDDVISACQADVLAVCVGPVTAAAFELWGIPSIYPADRSRLGAMVKLMETELPSRRQGLTLSLVGGHQLLLHGDAVVLDGAAVALSPAPAAVLQALVANPGNVVSRQALLAMLPSGTAGSEHAVEMAVARLRTALGTRSVQTVVKRGYRLAVSG
>NZ_CP049867.1|WP_166087795.1|3257587_3257935_+|nitrite-reductase-small-subunit-NirD
MTAGLSEARVAVCTLDAVPREGGVAALVHGEAVAVFRTHDDEVFALSNVDPVSRASVMARGILGTRGDAPFVAGPLYKQPWGLRDGVCLDDADLRVATYDVVVEDGTIWVGGRRT
>NZ_CP049867.1|WP_166087793.1|3254957_3257591_+|nitrite-reductase-large-subunit
MTHRQRLVVVGHGMVGHRFVQAAVERGLTATHDVVVVGEEPRPAYDRVALTSYFAASGAEALSLLPAEGYGDPAVTLLLGTTVTGLDRDARTLTLDGPDGEQVMSYDQLVLATGAAPFVPPVPGRELDGCFVYRTIEDLDAIRDASQRTGSGVVIGGGLLGLEAANALVQLGLETHVVEMAPRLMPVQLDGAGGSTLVRHIEKLGVSVHTGVVTDQITGEDGRVTGLALKDGPDTTVIDAGVVVFSAGIRPRDQLAREADLPVAERGGVLVDEQCRTVDPHVWAIGECAAPGGRMYGLVAPGYAMAEVVVDALLGGAGQFLGADMSTKLKLLGVDVASFGDAFAATPDSLELVYSDAVAGVYKKLVVTEDGRRLLGGILVGDASAYGVLRPMVASGIDLPDNPEELILPASRGGSTGSGVAALPDDAQVCSCNNVTKGAIVAAVSADGETDGPDTGAGHACEDVACVKRCTTAGTTCGSCVGTVKAIVEDHFAKAGRVVSKALCEHFALSRAELFEVVAIHRYRTFDQIVEAHGTGRGCDVCKPAVASVLASQFNGYVLSEETSTLQDTNDAYLANIQRNGTYSVVPRIPGGEITPEKLIVIGEVARDFKLYTKITGGQRIDLFGARMEELPLIWRRLVDAGFESGHAYGKSLRTVKSCVGSTWCRYGVQDSVTLAIDLELRYRGLRSPHKLKGGVSGCARECAEARGKDFGVIATEKGWNLYVGGNGGATPVHARLLAGDLDTATLVSYLDRFLMYYIRTADRLQRTAPWVDSLEGGLDRVREVVVDDVLGLGAELEAEMARHVDTYADEWATTLEDPDRLARFVSFVNAPGTPDPHISFGATRDQIVPEVADGPVVVATTIGVGAPGLEPTEAGR
>NZ_CP049867.1|WP_166090242.1|3253431_3254916_+|NAD(P)/FAD-dependent-oxidoreductase
MAATRLVEELVARGYPGHVTVLGDEPAPAYNRILLSAVLEGTHDRGAITLRRPGWYAEHGVTLRLGTRVLTVDREHRDVMLVDGETIGWDRLVLATGVIPTLPPMRGLVRVDGTLHPAVHAFRSLADCERLDAAVSAATGAASSHGSGPEAGPGGGPRRAVVVGGGLLGLQVARALALRGLRTELIEGSEHVLSRQVVPAAGQLLARSLRRLGTEVYVGARGVRLLDRPDPEGRPGVGVQLDNGHVLDTDLVVLTAGGRPSVALARNAGLAVRRGVVVDDQLASVTDAAVHAIGDCAEHRETLSGFVPPAWEQASVLARRLCGEDVAYEGTRAVARLRATDLDVAVLGDPVHAEGEVVEVANPLPGPDRAGKHSRLVVRDGVIEAASLVGDLSKVGLITQLYDRRTPLGLFDPGELLLPDPADEPLRPVLGEDAEVCACARVTVGRVRACADLDEARATTRATTGCGGCRDDVRALCGTSTRTQDPRPLSPTHS
>NZ_CP049867.1|WP_166087791.1|3251224_3253327_+|molybdopterin-oxidoreductase-family-protein
MTGTPRGASPGAAAGTAVETHCPYCSLQCGMRLAGRRTLEVRPWEEFAVNEGGLCRKGWTAAGLTGHRERLTTPLVRDRATGELRPVGWEAALDLVAERLGTIRDTHGNDAVGVFGGGGLTNEKAYLLGKFARVALGTSQVDYNGRWCMSSAASAANRAFGVDRGLPFPLADVEQTDVLVLVGSNLAETMPPAARHLDRLRARGGRVVVIDPRRTPTADRADVFLQPVPGTDLALALGVLHLLVAGGHVAEEYVDSRTSGFEAVRDSVASWWPERTERVTGVAATEVRALADLLAGAPKVTVLTARGAEQHAQGSDTVLAWINVALALGMCGEPHAGYGCLTGQGNGQGGREHGQKADQLPGYRSITDPAARAHVAGVWGVDPDSLPGAGRSAYELLDALGTPTGPRALLVHGSNIAVSAPNASHVVDRLAALDLLVVCDLVLSETAALADVVLPVTQWSEETGTMTNLEGRVVLRRQARSAPEGVRSDLDVLAGLAERLGCTAAFPTDPEEAFAELGRASAGGPADYSGITYDRITAEQGVFWPCPATPGEAHPGTPRMFTDRFATPDGRARFLAVEHRGTAEPVDAGFPVHLTTGRVLGQYQSGAQTRRVRDLPDTGPFVEMHPMLAARLGVADGLPVTLSTRRGELRAPARVVATIRPDTVFVPFHWLGVNRLTNDALDPASRMPEFKVCAASVVAA
>NZ_CP049867.1|WP_166087789.1|3249728_3251225_+|MFS-transporter
MATLHDAPTTRTEPGPDAPARRTRRWIDDWRPDDTDFWEGGGKKVARRNLLWSIFAEHLGFSVWLIWSVSAALLLATGFDFTPQQLFLLVAAPNLVGALIRVPYTFAVPTFGGRNWTVVSALLLLVPTLLFVWAVQNPQTPYWAFVAIAATAGLGGGNFASSMANINAFYPADKKGAALGLNAAGGNLGVSVIQFFLPIVVGGAGAFGLVAASGSIHLERAGWLYVALAVVAALAAYFLMDNLGTATASTKQTAAVVKRPQTWVMSVLYIGTFGSFIGYSAAMPLLIKLNFWVPAGGPTGTGINFAYFAFLGALIGSFTRPFGGWLADRFGGARVTVGAFLVMMAGTVVVLWTLTRLTPNPEALAAVAQDNTSWFPLFLGSFMVVFAATGVGNGSTYRMIPAIWRHRAEKATLPGTPDRELSLAAAVKESSAAVGIIGAVGALGGFGIPMMFGAPWIDDPVSAVRTAFVLFIGYYALCALVTWAVYLRRGAALAEAGV
>NZ_CP049867.1|WP_166087805.1|3261700_3262609_+|DUF2236-domain-containing-protein
MALISIPDVRERVGAAIFHKVAGPEGPERRERFHGREGERWFPAGSPIHVVHGDASMFIGGLRALMYQALHPVAMTAVAEHSGYRGDMWGRLARTSTFLAATTFATASDAQASVDVVRRIHDRITGTMPDGTPYIASDPHLLMWVHVAEIDSFLRAHVRYGKHKLDQAGRDEYVAQTAFVAEKLGVVDAPRTEAELAAVLESYRPELRGTDHAHEAISHLVWHPDLPVAVRPAYLVIAAAAIAMMPGWTRRELRLPRLPVTERTGVRVLGALATGTIRWAMTPPTDDGEEAVPAAPSHPAAR
>NZ_CP049867.1|WP_166087808.1|3262688_3263012_-|hypothetical-protein
MSTLVLSLAHSVQQLALVSLEALDEVPAPEDVRPGWVAMGSFFLLFAVTILLWMNMRKQIGKIKFDDGVDRSGPADPSADGSGPDEPGPDDAPVEPAPPHGSGTPRG
>NZ_CP049867.1|WP_166087810.1|3263008_3263884_-|mycothiol-conjugate-amidase-Mca
MLRLMHVHAHPDDESSKGAASTARYVAEGVDVHVATCTGGERGSILNPKMDRPDVLENITEIRRQEMERARDILGVRQDWLGFVDSGWPEGDPKPPLPEDCFALVPLEEAAAPLVRLIREFKPHVMTTYDERGGYPHPDHVKCHEISVHAFEAAGDPERYPELGEPWQVLKLYYHHSFNRPRMQAIHDAMIDHGLESPWGERLKEWTVEPEWDARITTRVPCADYFGVRDQALLAHATQIDPDGFWFAIPRELQEKVWPTEDYELVRSHVASSTPEDDLFAGVREHVGASS
>NZ_CP049867.1|WP_166087812.1|3263969_3264404_+|DUF4307-domain-containing-protein
MPDPRSDEVSDPSDLSERYGSTSPRQRVIATVLIVVVAVSSVGFVGWTALFHSTPEVQSRMTYFDFPDDRTAVARLTVVRDTPDTIATCLLRAVSEDFAIVGETEITVTTGPTTQAVEVEIPTERRATTVTTDGCTSNDQQRPR
>NZ_CP049867.1|WP_166087814.1|3264480_3265044_+|transcription-elongation-factor-GreA
MCATRSRRSPTHATRDSGAEPVTQSPEKDVVWLTQEAYDKLKDELENLRGPVREDIVARISAARDEGDLKENGGYHAAREEQGKLEGRIRQLEDMLERAEVGETPKDDGVVEPGMVVEIKFAGESESEKFLLGAREMAGDSDLQVYSPQSPMGSALIGAKKGDSVSFEAPNGKTLKVEVIHAEPYSG
>NZ_CP049867.1|WP_166087816.1|3265074_3266418_-|threonine-ammonia-lyase
MTDAPPAEPPAPATTPSEAPGGSSGSQDASDATSTGGAHVGPTLAEIEAAAELLRDVAVLTPLEESRWLSKIAGGPVYLKAENLQRAGSFKIRGAYVRMARLSPEERARGVVAASAGNHAQGVALAAQMLGITAVVYMPHGAPIVKERATRGYGAEVRFHGTTVDEALVQARAWSDETGAVLVHPFDHEDIVVGQATCGLEILEQCPEARTIVVPTGGGGLLAGIAAGVKPQRPDIRVVGVQAAGAAAYPPSLEHGSPQALSSMATMADGIAIGRPGDVPFAAVLEYVDDLVTVDEESLSQALLLLIERAKLVVEPAGAAAVAAVLENPARFETPMVVVLSGGNVDPILLMNVIRHGMATSGRYLALAVRIPDRPGGLAKLLGDLAAVQANVLDVVHQRTSSHLHIGEVEVALQLETRGPEHAEQVRTHLRGAGYPVTEESSAAQAE
>NZ_CP049867.1|WP_166087818.1|3266502_3267048_+|winged-helix-turn-helix-transcriptional-regulator
MTRSPSTRLTDTVLRRDDAVEDTFMAVLIAVGSVLRQRLPGDEHDFSLLPVLVELDRCGPVRLTDLAERLRLDASTVSRRVKNLGEQDLVATTTDTADGRARRVQIRPAGRRALGQLRARRRDLLGQVLADWPAEERDALQALLARFLDDLTADSGLLGAGTPTLPPTGSRSTPSPKDSPR
>NZ_CP049867.1|WP_166087820.1|3267044_3268598_+|MFS-transporter
MTPDAQGYLSHRQILVVMTGLITGMFLASLDQSIVSTALPTITSDLGGLDHLSWVVTSYLLASTASTPLWGKISDLYGRRPIFQIAILTFVAGSVLSGFSASMEQLIAFRAIQGLGGGGLMALALATIGDVVPPRERPRYQGYIAGTFGASSVLGPVLGGFFADGPGWEWIFFINVPIGLVALVVTSSALTMPHVRRDHSIDYLGAAVIVGSVSSLLLYTAWAGPEDGWGSPLGLALLLGGLALAALFVLVELRAKEPIIPMRLFRISIFSVANAFGFLIGAAMFGVMVFIPVYLQLVKGMSPTESGLGMLPMVIGLFTTSIWGGRWMSRTGHYKWFPPIGASVVLVSVGLMTQLGSDSPYWFAGLAMFVMGCGLGLTMQVLTVAVQNAVDRSEMGVATSSVQFFRQMGGSFGTALFGAVLSTRLASELTAASDQAGGAIPLDRVDELTSNMSLVDALPAQAQALVVDAFSSALSGTFLVAVPIVLAALVVGLFMKEIPLGSRETPVTETEKVPDHA
>NZ_CP049867.1|WP_166087822.1|3268631_3269279_-|TetR/AcrR-family-transcriptional-regulator
MPPSPYHHGHLRQALVDAAEVAVRDGGPSALSLRDLARRVGVSHNAAYRHFAHRDDLVTEVALQAMAHLLDTMERRLARIRTEDPVLRARQRLAEVGRGYVEYALAEPGLFSLAFSSSSALAQAGDSADRDPYALLGRVLDELVDVGFLAPGARVGAEIVCWSGVHGFSELCVSGALGATTADDRDVALDRVLVAIDRSFAATSGAVVGPEDLRF
>NZ_CP049867.1|WP_166087824.1|3269370_3270906_+|MFS-transporter
MSRKSLILLTVCMATLTINLSTMIVNVALPTLAAELDAGTRDLLWIVDGYNLAFAALVLAMGSLSDRFGRRPALIGGLVGFGASSAAAALTDSSGALIACRVAMGVFAAVIFPTTLSIISNTFSDRRERATALGLWGAAVGLGVALGPVTGGLLLEHSSWQSIFWAQVPVALLTAGLAVAFVPESRDPSVPPIDRAGFATSVAALGTLTWTIIEAPEHGWSSTETLTGFAVAAVLLAAFVLVERRVEHPMIDVTLFADRRFSAACASVTIAFFALFGFVFLITQFFQFVRGYDPLETGLRFLPVALAIAVASVVGSQLAPRLGTKLVVAPGLFLLGGAFLWISFIPADVSYASVVVPQMLLLGSGIGLVSTPATEAILQVLPPARAGVGSAVNDATRELGGTLGVAVVGSLFSSLYSDKLLDLVEGRLPADLAEKAADSVGFADVLAARVPTLGAAVDTAFLDGFGLACTVVGLLCVVGGTAALVALPGNGYDPAEQQASDDEPAPATAAG

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Crispr_ID: NZ_CP049867_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049867_15

3509343-3509415

Orphan

Consensus_repeat	Method
CCGTACGTCGTTGACGACGTGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049867_15

>merge|NZ_CP049867|15|3509343-3509415|CRISPRCasFinder
CCGTACGTCGTTGACGACGTGGGGACGCCCCAGCCCAGCTCCCCACCGTCCGTACGTCGTTGACGACGTGGGG

>NZ_CP049867|15|15|3509343-3509415|CRISPRCasFinder
CCGTACGTCGTTGACGACGTGGGG	ACGCCCCAGCCCAGCTCCCCACCGT
CCGTACGTCGTTGACGACGTGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049867.1\|WP_166090302.1\|3509423_3510254_-\|class-E-sortase	unknown	unknown	gnl\|CDD\|320679
NZ_CP049867.1\|WP_166088270.1\|3503420_3505007_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378057
NZ_CP049867.1\|WP_166090306.1\|3520459_3520906_+\|pilus-assembly-protein-CpaE	unknown	unknown	unknown
NZ_CP049867.1\|WP_166088261.1\|3500189_3501464_-\|S8/S53-family-peptidase	unknown	unknown	gnl\|CDD\|173787
NZ_CP049867.1\|WP_166088263.1\|3501576_3502326_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049867.1\|WP_166088276.1\|3513368_3515522_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP049867.1\|WP_166090300.1\|3497319_3498675_-\|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl\|CDD\|274855
NZ_CP049867.1\|WP_166090304.1\|3517734_3518289_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|184546
NZ_CP049867.1\|WP_166088282.1\|3516464_3517673_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237665
NZ_CP049867.1\|WP_166088278.1\|3515561_3515924_-\|response-regulator	unknown	unknown	gnl\|CDD\|381116
NZ_CP049867.1\|WP_166088280.1\|3516022_3516472_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133394
NZ_CP049867.1\|WP_166088259.1\|3496044_3497199_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|237171
NZ_CP049867.1\|WP_166088267.1\|3502509_3502806_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|274862
NZ_CP049867.1\|WP_166088268.1\|3502858_3503170_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|274862
NZ_CP049867.1\|WP_166088284.1\|3518423_3520271_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NZ_CP049867.1\|WP_166088254.1\|3493289_3494579_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|274856
NZ_CP049867.1\|WP_166088256.1\|3494575_3495958_-\|type-VII-secretion-protein-EccB	unknown	unknown	gnl\|CDD\|368288
NZ_CP049867.1\|WP_166088286.1\|3520886_3521441_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|130469
NZ_CP049867.1\|WP_166088272.1\|3505226_3509297_+\|type-VII-secretion-protein-EccCa	unknown	unknown	gnl\|CDD\|274858
NZ_CP049867.1\|WP_166088274.1\|3510562_3513160_-\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529

Protein	Function_ID	Function_description	E-value
NZ_CP049867.1\|WP_166090302.1\|3509423_3510254_-\|class-E-sortase	gnl\|CDD\|320679	cd05830, Sortase_E, Sortase domain found in the class E family of sortases. Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	5.19407e-43
NZ_CP049867.1\|WP_166088270.1\|3503420_3505007_-\|hypothetical-protein	gnl\|CDD\|378057	pfam08817, YukD, WXG100 protein secretion system (Wss), protein YukD. The YukD protein family members participate in the formation of a translocon required for the secretion of WXG100 proteins (pfam06013) in monoderm bacteria, with the WXG100 protein secretion system (Wss). Like the cytoplasmic protein EsaC in Staphylococcus aureus, YukD was hypothesized to play a role of a chaperone. YukD adopts a ubiquitin-like fold. Usually, ubiquitin covalently binds to protein and flags them for protein degradation, however conjugation assays have indicated that the classical YukD lacks the capacity for covalent bond formation with other proteins. In contrast to the situation in firmicutes, YukD-like proteins in actinobacteria are often fused to a transporter involved in the ESAT-6/ESX/Wss secretion pathway. Members of the YukD family are also associated in gene neighborhoods with other enzymatic members of the ubiquitin signaling and degradation pathway such as the E1, E2 and E3 trienzyme complex that catalyze ubiquitin transfer to substrates, and the JAB family metallopeptidases that are involved in its release. This suggests that a subset of the YukD family in bacteria are conjugated and released from proteins as in the eukaryotic ubiquitin-mediated signaling and degradation pathway.	1.41606e-05
NZ_CP049867.1\|WP_166088268.1\|3502858_3503170_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	2.72112e-09
NZ_CP049867.1\|WP_166088261.1\|3500189_3501464_-\|S8/S53-family-peptidase	gnl\|CDD\|173787	cd00306, Peptidases_S8_S53, Peptidase domain in the S8 and S53 families. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) family include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	6.01873e-20
NZ_CP049867.1\|WP_166088276.1\|3513368_3515522_+\|PAS-domain-S-box-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.68491e-51
NZ_CP049867.1\|WP_166090300.1\|3497319_3498675_-\|type-VII-secretion-integral-membrane-protein-EccD	gnl\|CDD\|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	1.72725e-13
NZ_CP049867.1\|WP_166090304.1\|3517734_3518289_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|184546	PRK14163, PRK14163, heat shock protein GrpE; Provisional.	1.77458e-49
NZ_CP049867.1\|WP_166088282.1\|3516464_3517673_-\|molecular-chaperone-DnaJ	gnl\|CDD\|237665	PRK14295, PRK14295, molecular chaperone DnaJ.	9.6714e-168
NZ_CP049867.1\|WP_166088278.1\|3515561_3515924_-\|response-regulator	gnl\|CDD\|381116	cd17574, REC_OmpR, phosphoacceptor receiver (REC) domain of OmpR family response regulators. OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	5.2754e-33
NZ_CP049867.1\|WP_166088286.1\|3520886_3521441_-\|hypothetical-protein	gnl\|CDD\|130469	TIGR01402, Flagellar_biosynthetic_protein_FliQ, flagellar biosynthetic protein FliQ. This model describes FliQ, a protein involved in biosynthesis of bacterial flagella. A related family of proteins, excluded from this model, participates in bacterial type III protein secretion systems. [Cellular processes, Chemotaxis and motility].	0.00101879
NZ_CP049867.1\|WP_166088259.1\|3496044_3497199_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	1.56118e-09
NZ_CP049867.1\|WP_166088267.1\|3502509_3502806_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.15308e-15
NZ_CP049867.1\|WP_166088274.1\|3510562_3513160_-\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP049867.1\|WP_166088284.1\|3518423_3520271_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP049867.1\|WP_166088254.1\|3493289_3494579_-\|S8-family-serine-peptidase	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	1.57546e-66
NZ_CP049867.1\|WP_166088256.1\|3494575_3495958_-\|type-VII-secretion-protein-EccB	gnl\|CDD\|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	6.27965e-56
NZ_CP049867.1\|WP_166088272.1\|3505226_3509297_+\|type-VII-secretion-protein-EccCa	gnl\|CDD\|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP049867.1\|WP_166088280.1\|3516022_3516472_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133394	cd04766, HTH_HspR, Helix-Turn-Helix DNA binding domain of the HspR transcription regulator. Helix-turn-helix (HTH) transcription regulator HspR, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	9.50152e-34

>NZ_CP049867.1|WP_166088272.1|3505226_3509297_+|type-VII-secretion-protein-EccCa
MRPASAGTPLLPARATAHVLRGGPRLSTTLSHGSRLDPPTMPDGELVLQAPPELAPNEGAGGALMMALPMLGSVGSIVFISAAQPGGKSMIAAGMFLVATLGFIGVQIDRQRKQRSAKIGGARREYLQYLAGVRKVVREAADQQRRTLLWHHPAPAALPALAEERQRLWERGPDHEDFLLTRYGRSPQALALRLVPPETAPVEQLDPVAASALHRLLVVHRNQPDLPAKVDMQAFSRIEVTGDEGPARGLARAMVCSAAAAHRPDEMIVAVLTNDQSVAAWEWAKWLPHAQSTEDADAIGPSRMVCDSLDDLAAMLPKDLVDRPRFGAAGAAATPHLLLVVDGGSLPPGNHLIPDEGVHGVTVLDLPEQWGELSDPTRLRLHLEGEATEDGTVPLTGIQVYRDPFRALGDQMDLASAEAFARRLAPLHTVQGPAREDSLSRAPELPDLLGLADVRTFDLDAAWQTRPQRDRLRVPVGIGDSGGPVLLDIKESAQQGMGPHGLVIGATGSGKSEFLRTLVLGLAMTHSSEVLNMVLVDFKGGATFAGLSEMPHVSAVITNLENELTLVDRMQDALSGEMVRRQELLRISGNYASLKDYEKARTSGEAELDPLPSLFIVVDEFSEMLSAKPEFIDLFVAIGRLGRSLGIHLLLASQRLEEGRLRGLESHLSYRIGLRTFSASESRAVLGVPDAYELPSVPGLGYLKPDQSTLLKFKAAYVSGPPPRVGRGTVNRSSGGLQTVMPFSLGHVLAPHQDEPEDQVVEVRSGSEEAADHRSLLDIAVDRMEGHGPGAHKVWLPPLDVPDTLDELMPDLTEDPELGLVSPSWRGRGGLVVPLGTVDRPREQRRDTLTVNLTGAGGHVAVVGGPRSGKSTLLRTVLTSLALTTTPAETQFYVLDFGGGTFAPLIDLPHVAGVATRSEPDVVRRIYAEVLGIVDKRERYFRSQGIDSIETYRSRRAQGRADDGYGDVFLFVDGWSTLRSDFDELEMALQSLAQRGLTFGLHIVAGAARWADFRAATRDVLGTRLELRLGDPMDSEIDRKVAQLVPNGRPGRGLVPAKLHFLAALPRIDGEPDGNTTGTGVEDLVERSRKAWRGEQGPKLRLLPEKIELAQVHEQVGRQRDLTTDRRLYLAIDEKDLAPVGLDVEREPHLLTFGDSRSGKSALLRAYLSEVMRTRTAEEAQVVVVDYRRSLLGEVPEDYALHYLTSATQAQPAIAELAQYLEGRLPGPDVTPEQLRNRSWWTGAEVFVVIDDYDLVSTQSSSPMAPLVPLLAQARDVGLHLAVARRSGGAARALYEPVIQSLRDLAMPGLLLSGSPDEGPLIGTTKPRPGVSGRGQLITRDRGVEVVQTVWTDASI
>NZ_CP049867.1|WP_166088270.1|3503420_3505007_-|hypothetical-protein
MSTDAQAVARSSVRVTVVGPDGTADLVVPWWMTATELTDEYAAYVGSSRPAGAGLVTASGHPLDADQELQQLGVEHGDVLIVADGGVTPAAPQTPGVGTPGPRPDAPVVLTTTGAGAGGAGGRAGRAASTRARDRSGDPAPADPSRPGASAVPAPTEAERAGAADARRARRTGVTSGATLGMGAVCAVGSAAVVAVQGSASQRLGCAAFFVLAALATAFPLRTSQIGGRLRAAASPAFAAAAGFTAGYSDETGGLLLGLAVAALCATGAAAVARAWLSQEEEELTDVALVVGATLSGLTLLLLLLGSSVLSLLAIAYGAAVVAARLLPYLVVDVPDEALLDLDRLQNTAWSAREQPRGSRRKRVIVRPDGVAAVVRRGQRLMTSGTVVISAVVVVGGALLVRDAELDVLGVSRVAMVLLGAAALALVARSVRARVPRLALRLSAGVVAAWTGLTLLDVGDPRATWWIFAVGGALGALTVSVGLALGQGWRSVWWARLADVCEALAVVLVVAAVPLASGIFGAVRSLVS
>NZ_CP049867.1|WP_166088268.1|3502858_3503170_-|WXG100-family-type-VII-secretion-target
MAGEVSKQDQSLTKGAQMVSSARGDLDQQLGSLRGKLAGIGAQWRGAGSSAFQQVMTRWDEDARKITSALNEFEANLRSSEQVYNANDESQSSTFSKLSGRLG
>NZ_CP049867.1|WP_166088267.1|3502509_3502806_-|WXG100-family-type-VII-secretion-target
MSGAGELKVNFGSLDAAAADIQSQANQIEGRLDALESELAPLRSDWTGEASNSYQVAKAKWDTAMADMKALLAEIGTAVTSSNSDYQATESQNTARWG
>NZ_CP049867.1|WP_166088263.1|3501576_3502326_-|hypothetical-protein
MVNADSGGGGSTDIPAGAVSGQIEITIEAIRRIARDNMAAMQDNATSQSSDFRALDLAPSAFGQVPIAQTVGQQHQAAHQVFMDTIDGVIADLETFAANIEASCNAHEATDEQSAADAQRAGQGALSGLNESMSGYQSQADQNFDNAGAEHREELGDPPPAAEQREGSEPPAGSERPEGNDGATGNTDSPETYSYGAGDDSGSTESSTTTFEGDAAPTPIATSFDADGDGTIDVLEPALPSSGSGTQAQ
>NZ_CP049867.1|WP_166088261.1|3500189_3501464_-|S8/S53-family-peptidase
MAPTPADAASSPGASWWFEALGVPEAHEETTGEGATVIMADGSIDATVPALEGSSLELRQGCLGEQMESNRVPDAEHGTWMASLVAGTGRGSGSAGGGIAGIAPDAELQYFTLDADPNSPGISCKVEMLEILGQAVRGVEGGPILSLSLGNLATGWDQLQRDVEELGGVAVASAGDYEDSVNRGMMDFPAAHAGWVAVMALDDQARPWDANPLPYRSLGKYRGYPTIAAPGVGVPGYTWKGDRFVAGEPQDGTSPATAIVAGALALVRSKYPEATGNQLIQHLIHFDAEPEEFAYSDAVGFGVVSLRNMLANDPTGWPDENPLMEGNPQRVIDTYPMSVYGQADDGADAEADAGDTTGEPEASSEDGSETTAEATGAPAQAGDDGSSSALPWLLGGGVALLLAAGGVVLARRSGGSGSTTRTNA
>NZ_CP049867.1|WP_166090300.1|3497319_3498675_-|type-VII-secretion-integral-membrane-protein-EccD
MEEPTSAAAPGASLVRVTVVGGGRRADLVLPATLPVAELLPELCRTVGVLDPATAYAGYELHASDGRRLSGEAGLTLQGVEDGAVLSVVVGADQRPPRVYDDIVEAMADAVEGDLQPWDPASGRRTALSAGALLLGLGGLALALQRPDPVAGAAAGVGALLLLAAALTLARVRAEHTAALVLAWTSAFYAGVAGLTVVDSGPVLELPLAATGGGVLLVGVIAFFGLVQRRALMLPAAVVGAVLAVGSGLAQATDLDPANVYVVALVVVVLAGSALPWFALGSTGTNVEQAHTHADLTAEPADIDPDAVRAGARMGHEVLLAVTATVGILLVLVSPLAVGLGVTGALVVVMSSVALMLRTRQYRVGSEVAVGLVCGVAGLAATAAAALLLQSSWHVGLALVLAAAAAVLLVSTLVPMPPSVRRGRLGDVAELVALVSLLPLLVVAIGVVGAV
>NZ_CP049867.1|WP_166088259.1|3496044_3497199_-|LPXTG-cell-wall-anchor-domain-containing-protein
MRSGRRLGAASLVTGVLLIGFASPSLAEEITGPSGALGDETEASSAEAGTDATAKRTSKASDARTRALAECDAAFEAGCTPKDLCKDADKLPNDPRLCAPKVTVQAVRTAAESGPAEGAAADGTEGSGTAVGEAADAGTAAREGVEGLLPGDGEDTDNGGGNDPDDGEGPPGPPGDPGEEDPDLPPGGGDDDDDDDDGGGLPVPCDPELGIPADPDGLCDDDDDDDGDPGDGDPGDGDPGDGDDDGDDGGVPPLPPIGGNDGDNGNGNGNGNGNGNGNGNGNGGDTSSDGDTGSGGAEAGGDVSSLGAAPQGEVSTNDDAVCTDAAVCGTVQPAATTTTSSSTGPTLPDTGAPAHTGLWVASGLGLLLAGGTLLRPRRRAEVRD
>NZ_CP049867.1|WP_166088256.1|3494575_3495958_-|type-VII-secretion-protein-EccB
MSSKRDLVEAHSFNRRRLVTAFVSGAPGGREVEPVRYGRTLVGGLVLALLIVAGAAVSGFIKPSVPEDWSNGGLVVGKDSGSRFVAVEGTLYPVINTTSARLLLASDGEEMKVNFVPEDLIAEAPTEATIGIQGAPDALPAPSSLVQSGWTACTDSTGGLAVSVGDTPVSTPVTDEALRVVDGEGSWIVTGNQRYQLPDAAKPQAAVLRALGLDDQPERGVTGVWLDLFPVGDPLVPFAVDGAGTQVNSTGVPGLTRVGTPLLVDGRPYALGQGGTLIPLSPFAAAVYTSSGRGAQLARLDIDVSNSDVAGLNLDDDTPYPESWPQEMVEDYATTDVECARLDTEEGAAPVVSLSAPTESAPAIVDGLFSRDIQPGGGALVQASPGGVLGTGSVFLVDSTGTRYAVGTPADSASTRASLGYAAVEPPSVPLPWTKIFRDGPALTRSAAGQPPVADQQGDS
>NZ_CP049867.1|WP_166088254.1|3493289_3494579_-|S8-family-serine-peptidase
MTRARRTPAHAGPARRAAALTAAAAVGLLLVPPAPAGAAETGEECPTADDPFIEQKSAAIINLGFPQSWELATGAGVTVAVVDSGVDVDNLHLGPDVVLPGTSFVSGPGVTADGRSDLYGHGTAVAGVIAAREIEGSGLVGTARDAKILPVQVFVSEGDDDVYNTGEPNSALMAAGIRWAVDNGADVINVSMSTDSEDADLPSLTQALDYAQSEDVVVVASAGNHAPASEDDALTASRYPAANENVIGVAATNTTGVVDAYTVHGPGSDVAAPGQNVLVASLGNRGDCVGGVDRPYSSWAAPFVAGLAAQLRELYPQASAEEIVYRILASADRPRLGYSDPVQGWGQIRPVEALTMTIDPTIPGPPLPRGLKRERPEATADVKALGAAVDPWADARQAALWWGLGGVGLTALALIVRPATRRRTASAEV
>NZ_CP049867.1|WP_166090302.1|3509423_3510254_-|class-E-sortase
MPVAAAPFEPLPRVAHDGAVSGTGATSAADPASPRPVPDSPDDATRGDDPARAPRRRRRWVPSSLRTVLGLVLVASGLGVLGWVGWQYYGTDFVARQAQQALVQRTEEAWEAQAAGDGPQAPLEVGAAEALIQIPRFGDDYVMPVQTGVGDDVLAEGFGHFEGAAAPGERGNYALAAHRVTHGEPLRKMPELRPGDEVVVTTRDAVHTYVMDTDPNDLVIGFENVWVVDPQPRNPDGGVGPASGEDRLITLTTCAELFHTDTRMIAFGHLVSSEPR
>NZ_CP049867.1|WP_166088274.1|3510562_3513160_-|ATP-dependent-chaperone-ClpB
MDSSKFTTRTQEAIAAAISGASTAGNTQVEAVHLLAALLAQPDNLTRPLLAGAGVDAAAVEAATKAQVSRLPAASGSTVSGPSYARAVLQVLTTAQTVAAELKDEYAAAEHVLVALATVESPARTLLVEAGATPEALRGALPQVRPGRVTSPDPEGTYEALEKYAVDLTQRANDGLIDPVIGRDEEIRRVVQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVDGDVPDSLKGRRLLSLDLSAMIAGAKYRGEFEERLKAVLNEIKESAGQVITFIDELHTVVGAGAGGDSAMDAGNMLKPMLARGELRMIGATTLDEYRERIEKDPALERRFQQVFVGEPSVEDTVAILRGLQEKYEAHHGVKITDAALVAAAMLSDRYITGRNLPDKAIDLVDEAGSRLRMEIESSPVELDQLRRAVDRMLMEELALARESDEASKDRLQRLRADLADRQEELRVMELRWEREKAGLEGAGELRKQRDELRSTYERLVREGDLEGASRIQYGEIPALEKRIAEVEHAGSEGDDAAEPMVHEEVGPEEIADVVEAWTGIPTGRLLEGETAKLLRMEDVIGERLIGQRAAVTAVSDAVRRSRAGIADPDRPTGSFLFLGPTGVGKTELAKALADFLFDDDRAIVRIDMSEYSEKHAVARLVGAPPGYVGYEEGGQLTEAVRRRPYAVVLLDEVEKAHPEVFDILLQVLDDGRLTDGQGRTVDFRNVVLILTSNLGSAYLVDPTVDAEAKREQVMAVVRQSFKPEFLNRLDEVVMFDALTRDELTHIVDLQVALLAKRLQVRRIGLDVTPAALEWLGRTGYDPAYGARPLRRLVQSAIGDPLARMLLSGEVLDGSTVRVDLEGDGLALSTAPTGG
>NZ_CP049867.1|WP_166088276.1|3513368_3515522_+|PAS-domain-S-box-protein
MTWVRRLGRHRVLGLVVLAVLALEVVFGQMAVRFAPPGSSVAAYWPNSGLSVVALILSSRRWRPATLGGVFLVTVLANLLGGRDLQVSAGFAMANAAEAGLAFWLLAQARDEPPVTGHGSPGPALSATGLPADRPDDDRPRLESVEDFIRLFVACAFASALGAVLAGATIGLLQDGDALVTGRAVLASHLASMLLIVPLSMRLPRDREHAAGPAEVLVQWATLTLVVGAVFFGTQGLPLVFLIYPILVWGALRAEPWVTALQLLVAGGAVAVLTTTRGGPYLDAIRDAGQPPELAGTLLQAHLLASALVTLPLALIKAQRLLALAEVTRSHEELDAILAATTATAIVGIGLDGRVEYVNVGAQHLSGYQASALLGRARVVVTPGPEPLLTFAEDGTGPSGEAPLREVVDPVLDASDGTVVQDWGFLRADGARLTVSVALSRRYAANGTPAGYLAVAEDVTERRQQEREVKEALASEKLVVDRLAQLDQTKNDFLSTVSHELRTPITSILGYSQLLMGQDASDLPAIQRQVVGRIERNGRRLMGLIEDMLAMSQIEVGSFGFTRVPLDAREPLALAVESTLPLLPARDLALEQRVSTEPVLVAGDADKLERAFENLLSNAVKFSNPGEQIVVRLAAEAGEAVFSVTDTGIGIESEDQEQLFDRFFRGSEAQTQAIQGAGLGLSIAATIVNGHDGSIDIESAPGRGSTFTIRLPLLEEV
>NZ_CP049867.1|WP_166088278.1|3515561_3515924_-|response-regulator
MTVVLAEDDVDIRDLVQLVLEGLDLEVTAVGNGEEALAACRRVTPRLLLLDITMPGMSGLEVCRAIRADEKLADLPIILMTARAQASDVTAGMEAGADTYIIKPFGPIELREHVEAILGT
>NZ_CP049867.1|WP_166088280.1|3516022_3516472_-|MerR-family-transcriptional-regulator
MPERERRRGPAPAPPAPDVPVYVISVAAELTGLHPQTLRTYDRLGLVSPGRSGGGGRRYSWRDIELLREVAELTAAGIGLEGVRRILQLEAMLAGLQDRLRQREDEVAALRYALQTARADRGSAANLPAVLGTDPGRSVVVWRRGPSNP
>NZ_CP049867.1|WP_166088282.1|3516464_3517673_-|molecular-chaperone-DnaJ
MTNADWATKDFYQVLGVAKDAPAAEIKKAYRKLARENHPDSHPGDTAAEDRFKAVAEAYDVVGDTTKRAEYDQTRSMFGGGGGWSPGPGGGYGDGVPFDINDLFGAGAGGAGGGFSDVLGDVFGRAGAQRGTGRRTRASARRGADLETSTTIGFTDAVDGVTVSLRLASDAPCEACRGTGAKAGTVPRMCPDCQGAGMRAASAGGAFTLNETCPTCRGRGMVVDDPCPVCRGAGRGLSDRSVQARIPAGVKDGQRIRLRGKGARGENGGPAGDLFVVVHVQPHRLFARTGDNLTLTVPIGFDEAVLGAEVKVPTLTGPVTVKVPPGTPSGRTFRVRGRGVPRRDGLKGDLLVTVEVQVPASPSDEVRAAAEAYREATAGSDLRGRLFEATGPTGSSGGGGDA
>NZ_CP049867.1|WP_166090304.1|3517734_3518289_-|nucleotide-exchange-factor-GrpE
MAGEAPGTGAAAGDAGDAATAPGSAASETEVRAAELTADLQRVQAEFLNYKRRVDRDRELVKQNATFTVLSALLPVLDDVDRAREHGELSGGFKAVAEALERVVAGQGLDKFGTPGDAFDPRLHEALMHGLSSEVDTTTCDKIVQAGYRIGERVVRPAMVTVVDPDPSGAAAPQDSEPAPEQQG
>NZ_CP049867.1|WP_166088284.1|3518423_3520271_-|molecular-chaperone-DnaK
MARAVGIDLGTTNSVVAVLEGGEPTVIANAEGARTTPSVVAFAKNGEVLVGEVAKRQAVTNVDRTIRSVKRHMGTDWSQKIDDKDFTSQQISAFVLQKLKRDAEAYLGETVTDAVITVPAYFSDAQRQATKEAGEIAGLTVSRIVNEPTAAALAYGLDKGDDQMILVFDLGGGTFDVSLLEIGEGVIEVKATSGDNHLGGDDWDLRLVEWMVKKFKDNNGVDLAKDKIAKQRLQEAAEKAKIELSSSTETTIHLPYITHGENGPLHFEERLSRSEFQKLTADLLERTKAPFRSVIKDAGVDVAKIDHVVLVGGSTRMPAVADVVRELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTKLIERNTTIPTKKSEVFTTADDNQPSVMIQVFQGERQMAAQNQPLGNFELTGLPPAPRGVPQIEVTFDIDANGIVQVSAKDRGTGREQKMTITGGSALSKDDIDRMVREAEQYAEEDAKRRETVEVRNQAETLAYSTEKFLSENEEKIPEDVRTEVQGDIEALKKALEDTSDTAGDEIAAAAAKLGESSQKMGAAMYAAGEADQAASGAGDAGTGDADDDVVDAEIVDDEEENK
>NZ_CP049867.1|WP_166090306.1|3520459_3520906_+|pilus-assembly-protein-CpaE
MDLELGLALARARRARGLRWDPRPGDHFVVPDRDLDDTVFVVSDMVVEVVQTAVGPVLAFNGTTEWALDSIEVDEAVWLPLEHQLREQLGEDLVSLAVVASPDLGPEQAPPGYAVTVRRGADEQRYLDVSPEAAYARAVLDGLSRPSR
>NZ_CP049867.1|WP_166088286.1|3520886_3521441_-|hypothetical-protein
MAKYEDERPGRTLLTAVAAMLGVALVVGLVIGGVAMVALKDVLGGSTEAAEQESEQSLFIPKYRATKGADDDPKIPGVQTPSSTEPLEQTKEPTKAKVTLFVAPQQVSPGERINFNGVYVDGEGASLQIQRREGGTWTDFPVTASVRGGSFETWIQTSRTGEQVFRVFDVAEERGSNTVTVTVG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	1584054-1584092	0	1.0
NZ_CP049867_4	4.1\|178593\|39\|NZ_CP049867\|CRISPRCasFinder	178593-178631	39	NZ_CP049867.1	4088707-4088745	1	0.974
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	314159-314197	1	0.974
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	347202-347240	1	0.974
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	1000683-1000721	1	0.974
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	2666686-2666724	1	0.974
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	2690517-2690555	1	0.974
NZ_CP049867_5	5.1\|254680\|33\|NZ_CP049867\|CRISPRCasFinder	254680-254712	33	NZ_CP049867.1	4060723-4060755	2	0.939
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	677883-677921	2	0.949
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	736525-736563	2	0.949
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	999507-999545	2	0.949
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	1113677-1113715	2	0.949
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	1135624-1135662	2	0.949
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	1889032-1889070	2	0.949
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	2366540-2366578	2	0.949
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	2520284-2520322	2	0.949
NZ_CP049867_14	14.1\|3261594\|39\|NZ_CP049867\|CRISPRCasFinder	3261594-3261632	39	NZ_CP049867.1	2648249-2648287	2	0.949

1. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 1584054-1584092, mismatch: 0, identity: 1.0

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	Protospacer
***************************************

2. spacer 4.1|178593|39|NZ_CP049867|CRISPRCasFinder matches to position: 4088707-4088745, mismatch: 1, identity: 0.974

gcgcttcccgcacgaaacttcgctcgggaagcgccaaca	CRISPR spacer
gcgcttcccgaacgaaacttcgctcgggaagcgccaaca	Protospacer
********** ****************************

3. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 314159-314197, mismatch: 1, identity: 0.974

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagcgatgcttcgctcgggaag	Protospacer
*************************.*************

4. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 347202-347240, mismatch: 1, identity: 0.974

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaactggcgcttcccgagcgatgtttcgctcgggaag	Protospacer
******.********************************

5. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 1000683-1000721, mismatch: 1, identity: 0.974

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagcgaagtttcgctcgggaag	Protospacer
*********************** ***************

6. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 2666686-2666724, mismatch: 1, identity: 0.974

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagcgatgcttcgctcgggaag	Protospacer
*************************.*************

7. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 2690517-2690555, mismatch: 1, identity: 0.974

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagcgatgcttcgctcgggaag	Protospacer
*************************.*************

8. spacer 5.1|254680|33|NZ_CP049867|CRISPRCasFinder matches to position: 4060723-4060755, mismatch: 2, identity: 0.939

gctcgtgtacgcgcgaaacgtcgctcgtgcacg	CRISPR spacer
gctcgtgtacgcgcgaagcgtcgctcgtgtacg	Protospacer
*****************.***********.***

9. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 677883-677921, mismatch: 2, identity: 0.949

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagtgatgcttcgctcgggaag	Protospacer
********************.****.*************

10. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 736525-736563, mismatch: 2, identity: 0.949

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagtgatgcttcgctcgggaag	Protospacer
********************.****.*************

11. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 999507-999545, mismatch: 2, identity: 0.949

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagcgaagtatcgctcgggaag	Protospacer
*********************** ** ************

12. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 1113677-1113715, mismatch: 2, identity: 0.949

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaactggcgcttcccgagcgatgtttcgttcgggaag	Protospacer
******.***********************.********

13. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 1135624-1135662, mismatch: 2, identity: 0.949

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagtgatgcttcgctcgggaag	Protospacer
********************.****.*************

14. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 1889032-1889070, mismatch: 2, identity: 0.949

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagcgaagtttcgttcgggaag	Protospacer
*********************** ******.********

15. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 2366540-2366578, mismatch: 2, identity: 0.949

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagcgatgcatcgctcgggaag	Protospacer
*************************. ************

16. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 2520284-2520322, mismatch: 2, identity: 0.949

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagtgatgcttcgctcgggaag	Protospacer
********************.****.*************

17. spacer 14.1|3261594|39|NZ_CP049867|CRISPRCasFinder matches to position: 2648249-2648287, mismatch: 2, identity: 0.949

cgaaaccggcgcttcccgagcgatgtttcgctcgggaag	CRISPR spacer
cgaaaccggcgcttcccgagcgatgcatcgctcgggaag	Protospacer
*************************. ************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP049867_15	15.1\|3509367\|25\|NZ_CP049867\|CRISPRCasFinder	3509367-3509391	25	NZ_CP010612	Phaeobacter inhibens strain P92 plasmid pP92_b, complete sequence	24264-24288	5	0.8
NZ_CP049867_15	15.1\|3509367\|25\|NZ_CP049867\|CRISPRCasFinder	3509367-3509391	25	NC_018291	Phaeobacter inhibens DSM 17395 plasmid pPGA1_262, complete sequence	23106-23130	5	0.8
NZ_CP049867_15	15.1\|3509367\|25\|NZ_CP049867\|CRISPRCasFinder	3509367-3509391	25	NZ_CP010596	Phaeobacter inhibens strain P10 plasmid pP10_a, complete sequence	24263-24287	5	0.8
NZ_CP049867_15	15.1\|3509367\|25\|NZ_CP049867\|CRISPRCasFinder	3509367-3509391	25	NZ_CP031953	Phaeobacter inhibens strain 2.10 plasmid unnamed1, complete sequence	23219-23243	5	0.8
NZ_CP049867_15	15.1\|3509367\|25\|NZ_CP049867\|CRISPRCasFinder	3509367-3509391	25	NC_018421	Phaeobacter inhibens 2.10 plasmid pPGA2_239, complete sequence	23126-23150	5	0.8
NZ_CP049867_15	15.1\|3509367\|25\|NZ_CP049867\|CRISPRCasFinder	3509367-3509391	25	NZ_CP031949	Phaeobacter inhibens strain BS107 plasmid unnamed1, complete sequence	23107-23131	5	0.8
NZ_CP049867_15	15.1\|3509367\|25\|NZ_CP049867\|CRISPRCasFinder	3509367-3509391	25	NZ_CP010651	Phaeobacter inhibens strain P54 plasmid pP54_a, complete sequence	24264-24288	5	0.8

1. spacer 15.1|3509367|25|NZ_CP049867|CRISPRCasFinder matches to NZ_CP010612 (Phaeobacter inhibens strain P92 plasmid pP92_b, complete sequence) position: , mismatch: 5, identity: 0.8

acgccccagcccagctccccaccgt	CRISPR spacer
tcgccgcagcccagctccccacgca	Protospacer
 **** ****************

2. spacer 15.1|3509367|25|NZ_CP049867|CRISPRCasFinder matches to NC_018291 (Phaeobacter inhibens DSM 17395 plasmid pPGA1_262, complete sequence) position: , mismatch: 5, identity: 0.8

acgccccagcccagctccccaccgt	CRISPR spacer
tcgccgcagcccagctccccacgca	Protospacer
 **** ****************

3. spacer 15.1|3509367|25|NZ_CP049867|CRISPRCasFinder matches to NZ_CP010596 (Phaeobacter inhibens strain P10 plasmid pP10_a, complete sequence) position: , mismatch: 5, identity: 0.8

acgccccagcccagctccccaccgt	CRISPR spacer
tcgccgcagcccagctccccacgca	Protospacer
 **** ****************

4. spacer 15.1|3509367|25|NZ_CP049867|CRISPRCasFinder matches to NZ_CP031953 (Phaeobacter inhibens strain 2.10 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.8

acgccccagcccagctccccaccgt	CRISPR spacer
tcgccgcagcccagctccccacgca	Protospacer
 **** ****************

5. spacer 15.1|3509367|25|NZ_CP049867|CRISPRCasFinder matches to NC_018421 (Phaeobacter inhibens 2.10 plasmid pPGA2_239, complete sequence) position: , mismatch: 5, identity: 0.8

acgccccagcccagctccccaccgt	CRISPR spacer
tcgccgcagcccagctccccacgca	Protospacer
 **** ****************

6. spacer 15.1|3509367|25|NZ_CP049867|CRISPRCasFinder matches to NZ_CP031949 (Phaeobacter inhibens strain BS107 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.8

acgccccagcccagctccccaccgt	CRISPR spacer
tcgccgcagcccagctccccacgca	Protospacer
 **** ****************

7. spacer 15.1|3509367|25|NZ_CP049867|CRISPRCasFinder matches to NZ_CP010651 (Phaeobacter inhibens strain P54 plasmid pP54_a, complete sequence) position: , mismatch: 5, identity: 0.8

acgccccagcccagctccccaccgt	CRISPR spacer
tcgccgcagcccagctccccacgca	Protospacer
 **** ****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1771813 : 1780352

Bacillus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_166085338.1\|1771813_1772602_+	Fe-S cluster assembly ATPase SufC	W8CYL7	Bacillus_phage	1.7e-05	24.9
WP_166085340.1\|1772603_1773881_+	cysteine desulfurase	Q2XUY6	environmental_halophage	4.8e-106	47.5
WP_166085343.1\|1773890_1774394_+	SUF system NifU family Fe-S cluster assembly protein	A0A1B1PCH2	Mycobacterium_phage	1.0e-19	43.0
WP_166085345.1\|1774390_1774777_+	metal-sulfur cluster assembly factor	NA	NA	NA	NA
WP_166085347.1\|1774895_1775513_+	hypothetical protein	NA	NA	NA	NA
WP_166085349.1\|1775534_1776512_-	peptidase	A0A1I9SA48	Rhodococcus_phage	6.0e-40	37.2
WP_166085351.1\|1776655_1778254_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2I4R674	Erysipelothrix_phage	3.1e-38	32.0
WP_166085353.1\|1778444_1780352_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.4e-48	27.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP049867

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection