CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP049223	Lactobacillus iners strain C0094A1 chromosome, complete genome	1 crisprs	cas8e,cse2gr11,cas7,cas5,cas6e,cas1,DEDDh,DinG,cas3	0	11	6	0
NZ_CP049224	Lactobacillus iners strain C0094A1 plasmid pC0094A1, complete sequence	0 crisprs	cas14k	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP049223_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049223_1

392093-393223

TypeI-E

I-C,I-E,II-B

Consensus_repeat	Method
GTATTTCCCGCACATGCGGGGGTGATCC	PILER-CR
GTATTTCCCGCACATGCGGGGGTGATCCT	CRISPRCasFinder
GTATTTCCCGCACATGCGGGGGTGATCCT	CRT

18 spacers

DEDDh,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,cas3

The CRISPR arrays of NZ_CP049223_1

>merge|NZ_CP049223|1|392093-393223|PILER-CR,CRISPRCasFinder,CRT
GTATTTCCCGCACATGCGGGGGTGATCCCGGAAGATTATAAAGAGTGGGACTATACCGCTGGGTATTTCCCGCACATGCGGGGGTGATCCTTAGTAAATCGCTTAGCAACATTGTTACAGTGTGTATTTCCCGCACATGCGGGGGTGATCCTGGTGTTTCTGGATATGTGCATGTCCAACGCTAGTATTTCCCGCACATGCGGGGGTGATCCTGAAGAGCTTTTAGTAAAAAGAGCTTTAGAGGGGTATTTCCCGCACATGCGGGGGTGATCCTTTAGAGAGCCTATGCAAAAGCTGCCACGAAAAGTATTTCCCGCACATGCGGGGGTGATCCTATAGCTTGCTTGCACTGCACCTTTAGCGAGTGGTATTTCCCGCACATGCGGGGGTGATCCCTATGGGAAGTTTTTACTTTTCTATGTCAATGCGGTATTTCCCGCACATGCGGGGGTGATCCTGGAAAACAACAATGCGGACTGGAAAGGCAGATGTATTTCCCGCACATGCGGGGGTGATCCTCAGCAAAGTAGCAAACGTATGACGAAAACCATGTATTTCCCGCACATGCGGGGGTGATCCTAGACGCACTTACGCAAAGTATGACTTACTTTTGTATTTCCCGCACATGCGGGGGTGATCCTAAAAGGGGTGATTCTGATGAGTTACACATTTAGTATTTCCCGCACATGCGGGGGTGATCCTTCAGGGTCAATAAAGCTACTAGACACAGAGTTAGTATTTCCCGCACATGCGGGGGTGATCCCGATCAATTTTTGGAAAGCGGGGAGTATATAGGGTATTTCCCGCACATGCGGGGGTGATCCTACTTGCGTCGGTATGTAGCCCGTTCCAGTTATGTATTTCCCGCACATGCGGGGGTGATCCTACGCCGTTGAGATGATAGAAAGCGACTTCAATGTATTTCCCGCACATGCGGGGGTGATCCTGTTGCGAAGTCAGTATTAGATGCTTTAAATCCGTATTTCCCGCACATGCGGGGGTGATCCTGACCAACTAAAAGATTTAGCAGGCATGGTAAAGTATTTCCCGCACATGCGGGGGTGATCCTCAACGCTTACTTCAAAGTAATAAAGTCACTTTAGTATTTCCCGCACATGCGGGTGACGATTT

>NZ_CP049223|1|1|392093-393160|PILER-CR
GTATTTCCCGCACATGCGGGGGTGATCC	CGGAAGATTATAAAGAGTGGGACTATACCGCTGG
GTATTTCCCGCACATGCGGGGGTGATCC	TTAGTAAATCGCTTAGCAACATTGTTACAGTGT
GTATTTCCCGCACATGCGGGGGTGATCC	TGGTGTTTCTGGATATGTGCATGTCCAACGCTA
GTATTTCCCGCACATGCGGGGGTGATCC	TGAAGAGCTTTTAGTAAAAAGAGCTTTAGAGGG
GTATTTCCCGCACATGCGGGGGTGATCC	TTTAGAGAGCCTATGCAAAAGCTGCCACGAAAA
GTATTTCCCGCACATGCGGGGGTGATCC	TATAGCTTGCTTGCACTGCACCTTTAGCGAGTG
GTATTTCCCGCACATGCGGGGGTGATCC	CTATGGGAAGTTTTTACTTTTCTATGTCAATGCG
GTATTTCCCGCACATGCGGGGGTGATCC	TGGAAAACAACAATGCGGACTGGAAAGGCAGAT
GTATTTCCCGCACATGCGGGGGTGATCC	TCAGCAAAGTAGCAAACGTATGACGAAAACCAT
GTATTTCCCGCACATGCGGGGGTGATCC	TAGACGCACTTACGCAAAGTATGACTTACTTTT
GTATTTCCCGCACATGCGGGGGTGATCC	TAAAAGGGGTGATTCTGATGAGTTACACATTTA
GTATTTCCCGCACATGCGGGGGTGATCC	TTCAGGGTCAATAAAGCTACTAGACACAGAGTTA
GTATTTCCCGCACATGCGGGGGTGATCC	CGATCAATTTTTGGAAAGCGGGGAGTATATAGG
GTATTTCCCGCACATGCGGGGGTGATCC	TACTTGCGTCGGTATGTAGCCCGTTCCAGTTAT
GTATTTCCCGCACATGCGGGGGTGATCC	TACGCCGTTGAGATGATAGAAAGCGACTTCAAT
GTATTTCCCGCACATGCGGGGGTGATCC	TGTTGCGAAGTCAGTATTAGATGCTTTAAATCC
GTATTTCCCGCACATGCGGGGGTGATCC	TGACCAACTAAAAGATTTAGCAGGCATGGTAAA
GTATTTCCCGCACATGCGGGGGTGATCC

>NZ_CP049223|1|1|392093-393223|CRISPRCasFinder
GTATTTCCCGCACATGCGGGGGTGATCCC	GGAAGATTATAAAGAGTGGGACTATACCGCTGG
GTATTTCCCGCACATGCGGGGGTGATCCT	TAGTAAATCGCTTAGCAACATTGTTACAGTGT
GTATTTCCCGCACATGCGGGGGTGATCCT	GGTGTTTCTGGATATGTGCATGTCCAACGCTA
GTATTTCCCGCACATGCGGGGGTGATCCT	GAAGAGCTTTTAGTAAAAAGAGCTTTAGAGGG
GTATTTCCCGCACATGCGGGGGTGATCCT	TTAGAGAGCCTATGCAAAAGCTGCCACGAAAA
GTATTTCCCGCACATGCGGGGGTGATCCT	ATAGCTTGCTTGCACTGCACCTTTAGCGAGTG
GTATTTCCCGCACATGCGGGGGTGATCCC	TATGGGAAGTTTTTACTTTTCTATGTCAATGCG
GTATTTCCCGCACATGCGGGGGTGATCCT	GGAAAACAACAATGCGGACTGGAAAGGCAGAT
GTATTTCCCGCACATGCGGGGGTGATCCT	CAGCAAAGTAGCAAACGTATGACGAAAACCAT
GTATTTCCCGCACATGCGGGGGTGATCCT	AGACGCACTTACGCAAAGTATGACTTACTTTT
GTATTTCCCGCACATGCGGGGGTGATCCT	AAAAGGGGTGATTCTGATGAGTTACACATTTA
GTATTTCCCGCACATGCGGGGGTGATCCT	TCAGGGTCAATAAAGCTACTAGACACAGAGTTA
GTATTTCCCGCACATGCGGGGGTGATCCC	GATCAATTTTTGGAAAGCGGGGAGTATATAGG
GTATTTCCCGCACATGCGGGGGTGATCCT	ACTTGCGTCGGTATGTAGCCCGTTCCAGTTAT
GTATTTCCCGCACATGCGGGGGTGATCCT	ACGCCGTTGAGATGATAGAAAGCGACTTCAAT
GTATTTCCCGCACATGCGGGGGTGATCCT	GTTGCGAAGTCAGTATTAGATGCTTTAAATCC
GTATTTCCCGCACATGCGGGGGTGATCCT	GACCAACTAAAAGATTTAGCAGGCATGGTAAA
GTATTTCCCGCACATGCGGGGGTGATCCT	CAACGCTTACTTCAAAGTAATAAAGTCACTTTA
GTATTTCCCGCACATGCGGGTGACGATTT

>NZ_CP049223|1|1|392093-393223|CRT
GTATTTCCCGCACATGCGGGGGTGATCCC	GGAAGATTATAAAGAGTGGGACTATACCGCTGG
GTATTTCCCGCACATGCGGGGGTGATCCT	TAGTAAATCGCTTAGCAACATTGTTACAGTGT
GTATTTCCCGCACATGCGGGGGTGATCCT	GGTGTTTCTGGATATGTGCATGTCCAACGCTA
GTATTTCCCGCACATGCGGGGGTGATCCT	GAAGAGCTTTTAGTAAAAAGAGCTTTAGAGGG
GTATTTCCCGCACATGCGGGGGTGATCCT	TTAGAGAGCCTATGCAAAAGCTGCCACGAAAA
GTATTTCCCGCACATGCGGGGGTGATCCT	ATAGCTTGCTTGCACTGCACCTTTAGCGAGTG
GTATTTCCCGCACATGCGGGGGTGATCCC	TATGGGAAGTTTTTACTTTTCTATGTCAATGCG
GTATTTCCCGCACATGCGGGGGTGATCCT	GGAAAACAACAATGCGGACTGGAAAGGCAGAT
GTATTTCCCGCACATGCGGGGGTGATCCT	CAGCAAAGTAGCAAACGTATGACGAAAACCAT
GTATTTCCCGCACATGCGGGGGTGATCCT	AGACGCACTTACGCAAAGTATGACTTACTTTT
GTATTTCCCGCACATGCGGGGGTGATCCT	AAAAGGGGTGATTCTGATGAGTTACACATTTA
GTATTTCCCGCACATGCGGGGGTGATCCT	TCAGGGTCAATAAAGCTACTAGACACAGAGTTA
GTATTTCCCGCACATGCGGGGGTGATCCC	GATCAATTTTTGGAAAGCGGGGAGTATATAGG
GTATTTCCCGCACATGCGGGGGTGATCCT	ACTTGCGTCGGTATGTAGCCCGTTCCAGTTAT
GTATTTCCCGCACATGCGGGGGTGATCCT	ACGCCGTTGAGATGATAGAAAGCGACTTCAAT
GTATTTCCCGCACATGCGGGGGTGATCCT	GTTGCGAAGTCAGTATTAGATGCTTTAAATCC
GTATTTCCCGCACATGCGGGGGTGATCCT	GACCAACTAAAAGATTTAGCAGGCATGGTAAA
GTATTTCCCGCACATGCGGGGGTGATCCT	CAACGCTTACTTCAAAGTAATAAAGTCACTTTA
GTATTTCCCGCACATGCGGGTGACGATTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049223.1\|WP_006729005.1\|401005_402379_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP049223.1\|WP_006736801.1\|407875_408970_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP049223.1\|WP_006735522.1\|389543_390203_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl\|CDD\|378050
NZ_CP049223.1\|WP_006728840.1\|381173_381953_+\|TIGR01457-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP049223.1\|WP_006734896.1\|387704_388781_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NZ_CP049223.1\|WP_006735507.1\|388797_389535_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	gnl\|CDD\|187886
NZ_CP049223.1\|WP_009310570.1\|393403_393589_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049223.1\|WP_164798658.1\|391138_392032_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
NZ_CP049223.1\|WP_164798657.1\|390199_391138_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NZ_CP049223.1\|WP_102695510.1\|393716_394361_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182775
NZ_CP049223.1\|WP_006731157.1\|408969_409833_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP049223.1\|WP_164798659.1\|402708_405303_+\|bifunctional-acetaldehyde-CoA/alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|237515
NZ_CP049223.1\|WP_160807912.1\|409834_410653_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NZ_CP049223.1\|WP_102695509.1\|394388_395336_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NZ_CP049223.1\|WP_006730473.1\|381952_382561_+\|TIGR01906-family-membrane-protein	unknown	unknown	gnl\|CDD\|377811
NZ_CP049223.1\|WP_006735481.1\|405468_406668_+\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP049223.1\|WP_164798656.1\|382676_385430_+\|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
NZ_CP049223.1\|WP_006733185.1\|387114_387702_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	mkCas0194_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NZ_CP049223.1\|WP_164798660.1\|406723_407713_-\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|187558
NZ_CP049223.1\|WP_102695513.1\|385416_387105_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|378189

Protein	Function_ID	Function_description	E-value
NZ_CP049223.1\|WP_006729005.1\|401005_402379_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	6.30429e-150
NZ_CP049223.1\|WP_006736801.1\|407875_408970_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	4.57404e-131
NZ_CP049223.1\|WP_006735522.1\|389543_390203_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	1.50803e-57
NZ_CP049223.1\|WP_006728840.1\|381173_381953_+\|TIGR01457-family-HAD-type-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.03299e-109
NZ_CP049223.1\|WP_006734896.1\|387704_388781_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	2.95314e-157
NZ_CP049223.1\|WP_006735507.1\|388797_389535_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|187886	cd09756, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	2.71205e-46
NZ_CP049223.1\|WP_164798657.1\|390199_391138_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	2.08871e-133
NZ_CP049223.1\|WP_164798658.1\|391138_392032_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	4.75595e-45
NZ_CP049223.1\|WP_102695510.1\|393716_394361_-\|hypothetical-protein	gnl\|CDD\|182775	PRK10847, PRK10847, DedA family protein.	8.31325e-66
NZ_CP049223.1\|WP_006731157.1\|408969_409833_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	7.0198e-65
NZ_CP049223.1\|WP_164798659.1\|402708_405303_+\|bifunctional-acetaldehyde-CoA/alcohol-dehydrogenase	gnl\|CDD\|237515	PRK13805, PRK13805, bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional.	0
NZ_CP049223.1\|WP_160807912.1\|409834_410653_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.07634e-62
NZ_CP049223.1\|WP_102695509.1\|394388_395336_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	1.0362e-50
NZ_CP049223.1\|WP_006730473.1\|381952_382561_+\|TIGR01906-family-membrane-protein	gnl\|CDD\|377811	pfam07314, DUF1461, Protein of unknown function (DUF1461). This family contains a number of hypothetical bacterial proteins of unknown function approximately 200 residues long. These are possibly integral membrane proteins.	1.48669e-30
NZ_CP049223.1\|WP_006735481.1\|405468_406668_+\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP049223.1\|WP_164798656.1\|382676_385430_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	2.48601e-98
NZ_CP049223.1\|WP_006733185.1\|387114_387702_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	7.09982e-30
NZ_CP049223.1\|WP_164798660.1\|406723_407713_-\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.08927e-175
NZ_CP049223.1\|WP_102695513.1\|385416_387105_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	1.60772e-86

>NZ_CP049223.1|WP_164798658.1|391138_392032_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MPLTVITLKKSPPSLRGDLTKWMQEISTGVYVGNFNSKIRSELWKRVIENVGMGTATMSYACRNEIGYNFEIHNSNKIPIDFDGIPLVMTPAIENSCSTEYKYGFSNAAKILKAKRYKGNISSIDTNTKPYVIIDLETTGLDYINNNIIEIGAIKIAKNIEEYSCIVKQNITLPNAIKILTGISDAELKNGKDESVAIKELCTFIGDKALVGYNVNFDIRFINEALKRNGQSQLTNKVYDVMKYVKRDKMFLKNYKLDTVLSEYGINIKVPHRAIEDVKIIQLLISKLDGLTNKSKI
>NZ_CP049223.1|WP_164798657.1|390199_391138_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MSKIIGAKKTELNELPRISDRVSFIYVEHAKINRIDSSITVSDYRGVVTIPCAIIGVLMLGPGTDISHRAIEILGDTGTSVIWVGERGVRYYAHGQSLSHSTKLLEKQAKLVSNTKTRLDVARKMYAMRFKNEDVSKLTMQQLRGREGARIRRLYREQATKFKVEWNRRDYKIHDFESSNIVNQALSAANVSLYGVCHSVIVALGMSPGLGFVHTGHDKSFVYDIADLYKAELTIPLAFSLAAEAKDNDDIGQLARLALRDKMLDGRVMQKIVTDLQYLMDISEDEKINADIIELWDDKGENTKYGINYTEE
>NZ_CP049223.1|WP_006735522.1|389543_390203_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSRVEIDLYNRKKIRELKHIGCYHGWIEDAFPDERDKPKSARSRKLWRIDNINDKCYLLILSESKPDFKKLEKYGIQHSACTKNYDEFLNSLKEGMRAKFRIKLNTVKSYSNREVYKKRGRVAPVSMDGLNSFFIERTEKNGFFVKDDEFRIIRREEERFEHYAEDKSEETNINLVSATYEGVLTITDLEKFKQTLTKGIGRKKAYGFGFLTIIPIK
>NZ_CP049223.1|WP_006735507.1|388797_389535_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MKTILLKLKGPMQSWGTSSHFETRTTDYYPSKSAVIGIIAASFGYKRDNDEKIQKLNELNFAIRIDQPGVLAKDYHIATKYKVNIDKKYKISVAFDRNYVTNRYYMEDAIFVVAISHADDQWIDSIYHALQNPYFTPFMGRRSCPLPADFIITVTNKDALDALQNLEWQAAKWYKRKHQNYCADIYADKDLNLQGIATTRNDRVVSFSQKERKFGPRFETRTSKDFTNGRNDASNSNSLDFYESI
>NZ_CP049223.1|WP_006734896.1|387704_388781_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MTNSINQRLFLDIHAIQTVPPSNINRDDTGSPKTAQYGGVTRARVSSQSWKRAIRKYFYDKGDTQNIGIRSCDIVKYIAKKIVDKDNSISVEDAITLVEKTLNAAKLSTKDQKLKALFFISNNQADKFAQACLDKKTDKTELQEILKTDTSIDIALFGRMLADDPSLNEDASSQVAHAISTHAIESEFDFYTAVDDLAPEDNAGAGMLGTLEYDSSTLYRYANIALHDFYKQLGDKEEVIDAVKLFVEAFVKSMPTGKINSFANQTLPQAVVVSLRSDRPINLVSAFEEPVKSENGYVDKSIQKLFAEYVKYEKILDKPIFTDYLLLDDTLEVKSIGKSTQNLDELLSDLKESINVNL
>NZ_CP049223.1|WP_006733185.1|387114_387702_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MEGSNVYNVTAKILRKINQTKDTSSTRALFANIRNSINKSSSNNLDALAFVFNNMPEEYIGFGKELSDYEQAILTAIQMYALHQQSNEKSVLKIEYNEGEKRQNLGDALSTLRGSDNKSIDRRFNAMILSSNYLQLQNHLRQFIKLLKAKSDAKVDYASVADDLFWFLKNQKDGVKIKWSRSYYKFRKVNDKGEN
>NZ_CP049223.1|WP_102695513.1|385416_387105_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MSDYNLIDEPWISVVVDYKGTTKLVGLKEFFEHAHEYIALAGDMPTQDFAVMRFLLAILHTVFSRYDAHGEPYEMIELNDRMQQIEKVDLEDEEDYEDALMETWKDLWNAKKFPEIVVKYLDAWHDRFYLFDDKYPFYQVTKEEIDTSKISKASPSKILGKNINRLISESGNKIALFSPKYDANNNKGLLTYDELTRWLITFQSYTGLSDKVIFGNEKYKASKGWLFDLGGVYLSSDNLYQTLILNLRLINRSNVNYNYSVQKPCWENAPSKLVEKAIRSSCIDNIAELYTTWSRAIYFNKFNMDDVFQMEIVKLPDIKHEDMFLEPMTLWKYNNVGDNKGKFTPRKHQLNKSLWRSFGLMTKFEEVGEVNAKIPKRKPGIIEWLNDIDESIKNQHIKINAISMEDDGNATSWVPINEVEDKLDIGEFIVNDLQKNGWVDRINNIVDRTKDIIEKNYRAFLNDIAKIRGIESGAFTSSSIESMYFKIDKPFRDWLTNINYDDNKDEKEQIWNKELKNLVIRQAKIIIEQASPKDFTGIIENDSVKNIVTAYNNLMSNINKKL
>NZ_CP049223.1|WP_164798656.1|382676_385430_+|CRISPR-associated-helicase-Cas3'
MEKYLWAKKNLVDGIPMWLPLTVHLNDTAEICGLLYEHWLSDGVKDFLEKAIISDVENKEDLLKNLCKFLGAVHDIGKATPIFQTKQSFCGDQELDNLINEKLKQAGFKKIDKYISERKNNVLHNISGQYFLNKCFKVNLCVANIIGAHHGRPVSQDQVMRECKSYTSSLYQDDNEKSSLAMFWKEIQRGIFDRAMEACNFSCVEDLPLISQPGQVILSGLLIMADWIASNEKYFPLIPIDTDKVESDRVETGFTKWYRDRAETWEPESYCNDIYQKRFGFEPREVQKKVSDIISKIDNPGIIIMEAPMGIGKTETALVAVEELAKKTNRTGIFFGLPTQATSNGIFSRVEDWLKHCEGEKSIRLIHGKAQLNDQFANLPKSRNIHDEDSIGVNEWFAGRKVAILDDFTVGTVDQVLLAALKQKHLMLRHLGFANKVVIIDEVHAYDAYMSVYLYQALMWLGAYGVPVILLSATLPISKRNELLEQYMVGAGYKFKKLDKPQDFDNNENYPLLTYNDGEKINQFSDFSQECGTDYKVIPKAKDESENIVNLINELTTNGGIVGVILNTVKKSQKFAEQCVNAFGEKNVELLHSSFIATDRYKKEQELINTIGKNGKRPKFKIIIGTQVIEQSLDIDFDVLITDLAPMDLLLQRMGRLHRHSDTKRPENLKKPQVYILNCGNYDFDEASTYVYAKYLLFRTEYFLPNKVNLPNDISHLVQLVYSDNALNLSDDSLKKDYTTYQGKYNADIDKKEQQAEVYRLVKPLKKISQEKNLSDWIKNSNHSAELSDVNAYAQVRDSADSVEVIALKKCEGGYEFFDKSGKLDPTDNKTAMEIAKRTIQLPSATYYGIGIDEVIKELEKYYLKHFQDWNQQSWLKGSLAIIFDQNDEFSLLNKKILRYNNKYGLKVVTEDINERL
>NZ_CP049223.1|WP_006730473.1|381952_382561_+|TIGR01906-family-membrane-protein
MKNKLSIVIYNFGAAILLSLWGTILLSWPILLVMMIAQRTNKLIHLSLFGALKNYSQLMSYLINPVSDKLQMSDLQSSLNGLIHFKDCKNLFSIALMLGCIWLFIFLYFEIWKKKKIVSLPHSYTICLLLLPLIVVPFSMGNFTNLFILFHRAIFTNNNWLFNPDTDPIILILTEEFFAACSATFLLIYELYFVRLLIKKGR
>NZ_CP049223.1|WP_006728840.1|381173_381953_+|TIGR01457-family-HAD-type-hydrolase
MNKQYGCYLIDLDGTIYRGEKTIQSGVDFVNRLNEKKIPYLFLTNNTTRTPEMIVAKLASHGVITDVDHVYTPIMATVSYLLEHNPGTDAIPVYIIGQIGLWKGLLAEDRIVLDNNNPKYVIVGMDTDLTYKKICIATNAIRKGAEFIGTNSDHVLPSGDKLLPGNGSQCAMIAVASDQKPFFIGKPSAVIVNYALKKIKKNIEESLIVGDNYETDIMAGINCRMDSLLTLTGVTTKKQLAEEKIQPTYVLNNLDEWQL
>NZ_CP049223.1|WP_009310570.1|393403_393589_+|hypothetical-protein
MGRELMGLASCDDDRKAIINFTIVAAKYFNDQVTVEKINDSLKEHSQAPLTEEEKKFYGVK
>NZ_CP049223.1|WP_102695510.1|393716_394361_-|hypothetical-protein
MNLLDFILNIDKHLITIVNSCGDWTYLILFLIVFMETGLVVFPFLPGDSLIFATIAMAASPKYHLDLIICYIIFIIAAICGDSINYELGKWSELQSNKFKWFNKLINPQKKKAAEDFFEKHGGITIVIGRFIPIIRTFVPFVSGASKMHYRTFVIYNIVGAFLWVSLFSICGFLFGNIPAVQHHFSLLIIAIIAISILPIIILSIKNKLTKNSK
>NZ_CP049223.1|WP_102695509.1|394388_395336_-|NAD(P)/FAD-dependent-oxidoreductase
MEYYDLAIVGAGPVGLFATKFANLHGLKTITFEALADCGGQINRLFPNKKIKDIPGYNSIIGHQLVDKLKEGIDSKIITNYKVQEIIQKGSEIIIDNNYQAKTLLITSGMGAFTPKKLPLPIDSSCEKHIHYFVKNADHFQDKNVAIFGGGDSALDWAMQMADKCKIVIIHRRDQFRGMESTLKFLHQHNNVRFLTPYLPQKIIWQNNQLNILLKKLGTEEMEEIKCDEAVIAFGFKSDNLLLKKWGLNLETGHVKVNSQMQSNIENIYAAGDACIYDGRVPMMALGFGEAQIAIMSIMNHLFPEKKLTIHLSSH
>NZ_CP049223.1|WP_006729005.1|401005_402379_-|amino-acid-permease
MKQKKSHSSKDISMKRSLTNTHIQLIALGGTIGTGLFLGVGNSIELAGPAVILIYTLVGFFLFLLMRALGELILSDLNKNTYIDFITQYLGKVIGTVTGYLYWFSWLSLGMAELTALGLYFRYWWHDLPLWLPGSITLIILLMINLISAKVFGNMEFSFAIIKILTIVAFVLLVFYLLITNGSTKLYGAISFSNLFKDGGFFAKGANGFFSGFQMVIFSFIGVELIGLTAAEAQDPKKTIVKAINELPVRIILFYVLAILAILLVIPWKQVAINDSPFVQALGATGIKNAACIINFVVISAAISSTNTFIYSGGRLLFSLNYHGQSNFAKCMGQLNKRQLPENALLFSTLLIGIAPIMNLFLENAFHFIAATSTSMFLIIWSIMIWAHIRYRKQTPEQQLHNFRMPLYPYTDYLVLGFFITMIGLLLWVPKDRIPMISALVIFSILILSIKFIKKIK
>NZ_CP049223.1|WP_164798659.1|402708_405303_+|bifunctional-acetaldehyde-CoA/alcohol-dehydrogenase
MAKEIASTTKKEQIDVQAMIDSYVVQAHVALDKMANFSQEQVDKICEAIAKVGEQNSYLLAKMAVEETGRGIVEDKTIKNMFASENIWNSLRHEKTVGIISEDPERQLIKIAEPVGVIAGVTPVTNPTSTVIFKSMIALKTRNTIIFGFHPQAQKCCVKTAELIREAAIKAGAPDNCIQWIEYPSIEATNALMTHPNIQTILATGGPGMVKAAYSSGKPALGVGPGNGPAYIEKTANYQRAAYDIILSKTFDNGMVCASENSVVIDKDIYDKVKKEFEAWNCYFLNKEEIKKFETTFIDPRRGTVAGPIAGKSAYEIGKLCGVDVPEDTKVIIAEYSGVGKEYPLSAEKLSPVFTMYKVSGADEAFKICKDLLSYGGRGHTVGIHTEDKELIKKFALAMSACRILVNTPAALGGIGDLYNNMLPSMTLGTGSYGANSMSHNISAADLLNIKTVAMRRDNMQWIKVPKKTYFEHNAANYLKHMPDVEKFFIVTDETVAGKYANQITDIISQRLGKKSYEVFQAVKEHPTTDVILDGVHRMNIFKPDAIVALGGGSVMDAAKIMRLFYENPDMTLEDSYQKFIDIRKRVVRFPKTNMVQLVCIPTTSGTGSEVSPFAIIKDTQTGIKHTLCDYSLNPDVAIVDDNFVETLPAKLVANSGMEALAHAMESYVSTMATDFTRGWSMEAIKLIFANLEKSYKGDQAARSKMHNASTLAGMAYANAFLGVGHAIAHTLGSTFNIPSGLSDAITMPYVIKFNAQRPRKLPIRPHYSVFRADKDYAEIARSLGIQGKNDQELVDGLINKFVELAKSINMTLNLKDNGVSEADFNNKVEHLAVEAYGDQNIVTNPSAPLIKQIEQLMKKIYVG
>NZ_CP049223.1|WP_006735481.1|405468_406668_+|acetate-kinase
MKKILAINSGSSSFKYKLFNYPSEEVVAQGQAQRIGLAGSTFSLKLADGSKYESEIKIPDHKTAIQLLLTWLPKYNVINDLKEIAGIGHRVVAGGEIFSESALIDKEKLQQIYDLSDYAPLHNPYEADGIRDFMQLLPGVPQVAVFDTSFHHTLDPVHYLYSLPYKYYEKYRARKYGAHGTSVRYVSHRAAELLNKPLNTLKMIVCHLGNGASITAIKDGKSYDTSMGFSPVAGITMSTRSGDIDPSVLQYVMKKENISDFNKMINILNNKSGILGISDYSPDMRDIRKRAAAGDVKAKLAKDIFVNRIIKYIGSYYVDMGGLDALVFTAGIGENESLYRQAIVDKLSVLGLKIDEKANSVNGEKVISAVDSKAKILIIPTNEELVIARDVVRLAKINK
>NZ_CP049223.1|WP_164798660.1|406723_407713_-|UDP-glucose-4-epimerase-GalE
MNILVIGGAGYIGSHAVRKLLDLGYHVVVLDNLITGHRKAIDPRAKFYQVDLLNTFLVSKILRDEKIDAIMHFAAYSLVSESVQKPLLYYQNNITGMISLLNAMNDAKVKYLIFSSSAATYGIPEKLPITEEAPLKPINPYGETKMMMEKMMLWADKANNIKSIALRYFNVAGAASDGTIGEDHRTESHLIPNILKCADSHDKIFTIYGNDYQTLDGTNVRDYVEIEDLIDAHILALQHLIKTNLSDVFNLGTAHGYSNLEILECAKRITATNIPYKFGQRRGGDPDSLVADSTKARTILGWQPKHENIDNIIASAWKWHQKHPNGFED
>NZ_CP049223.1|WP_006736801.1|407875_408970_+|ABC-transporter-ATP-binding-protein
MNEDNFIQIKNLKMVYENGYQAISDISFTVKKGELVCLLGPSGCGKTTTLNMVAGLLNPTGGDILVDGKSVLNVAPKDRNIGYVFQNYALYPHMTVLQNVMFPMTVGKNKKSKEEAKQIAERFMRLTHIEEYANQKPGKLSGGQQQRVSIARALVQQPKILLMDEPLSNLDARLRLKIREEIRALVKKVGITTLFVTHDQEEALSIGDKIILFNEGVIQQDAASYEIYLNPANQFVANFIGNPVVDNFNVEVSDGKVKGDGFEIPLSAFDSDRFKKNITDGVYTLSLRPENVFPVDNQADGFFTCKIDDIELIGRERILKFTINGLGQRSLVKVEANVEPGDEICFGLNLDRAFIFDNNGERIY
>NZ_CP049223.1|WP_006731157.1|408969_409833_+|sugar-ABC-transporter-permease
MENNQKKAWLFLLPAIISVTIFSIWPIIRAFIISFQGGPLICLNFNGIENYKYIFADTDFWNSLTNTAIYAFMTVPIALAIALALAWFVFSKIRHQSFFEAMFFMPYVTSTIATGIVFRYIFNGKYGLLDFVLKMLHLPAPDWLDDPSMSLISLIIFGIWSSLAFNIVILIGALRNIDPNYYVLADMYGANESEKFWRITIPQLFPTLAFLLTVNLIGAFKVYTQVFALFNGSAGQGNSAITSVFYIYNKFQVANTPGVAMAATVCLFLFILFITCLQRKLMKRVNS
>NZ_CP049223.1|WP_160807912.1|409834_410653_+|ABC-transporter-permease-subunit
MKKIKTIFIYIFVTFFAIITVFPFIYMIFGGLMTYEETTRIPPTFVPGSFKISNYLAVFNQAPFARYFFNTFVTATTTTVVSLFTSILGAFAMANLKFKGKGLIKIILISLLMVPGEAIIFTNYTTIMSMGLINTYIGLVIPFLTSIFYMYYLQSYFKSITPTVYKAAMIDGASDWEYIWRILVPMSKSGLITVALLSFISGWNAFLWPLLVTNESDMRLLNNGLAAFATEAGSQTQLQLAAATLIVLPILIVYFVFRKQIIRGVVNHEFKA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP049223_1	1.17\|393100\|33\|NZ_CP049223\|PILER-CR	393100-393132	33	MN693811	Marine virus AFVG_250M463, complete genome	5399-5431	7	0.788
NZ_CP049223_1	1.25\|392551\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	392551-392582	32	NZ_CP017105	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence	1310511-1310542	7	0.781
NZ_CP049223_1	1.8\|392550\|33\|NZ_CP049223\|PILER-CR	392550-392582	33	MH248138	Erwinia phage vB_EamM_Alexandra, complete genome	237366-237398	9	0.727
NZ_CP049223_1	1.11\|392733\|33\|NZ_CP049223\|PILER-CR	392733-392765	33	MT104474	Pseudomonas phage MR14, complete genome	35210-35242	9	0.727
NZ_CP049223_1	1.17\|393100\|33\|NZ_CP049223\|PILER-CR	393100-393132	33	MN693872	Marine virus AFVG_250M911, complete genome	64918-64950	9	0.727
NZ_CP049223_1	1.23\|392428\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	392428-392459	32	MH341452	Listeria phage PSU-VKH-LP040, complete genome	14581-14612	9	0.719
NZ_CP049223_1	1.23\|392428\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	392428-392459	32	DQ003637	Listeria phage A500, complete genome	14546-14577	9	0.719
NZ_CP049223_1	1.23\|392428\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	392428-392459	32	KP399678	Listeria phage vB_LmoS_293, complete genome	14567-14598	9	0.719
NZ_CP049223_1	1.25\|392551\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	392551-392582	32	MH248138	Erwinia phage vB_EamM_Alexandra, complete genome	237367-237398	9	0.719
NZ_CP049223_1	1.28\|392734\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	392734-392765	32	MT104474	Pseudomonas phage MR14, complete genome	35211-35242	9	0.719
NZ_CP049223_1	1.32\|392979\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	392979-393010	32	NZ_CP017185	Enterobacter roggenkampii strain DSM 16690 plasmid pDSMZ16690, complete sequence	145066-145097	9	0.719
NZ_CP049223_1	1.33\|393040\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	393040-393071	32	NZ_CP016596	Bacillus cereus strain K8 plasmid pBCM301, complete sequence	16882-16913	9	0.719
NZ_CP049223_1	1.33\|393040\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	393040-393071	32	AP013413	Uncultured Mediterranean phage uvMED DNA, complete genome, group G16, isolate: uvMED-CGR-C48A-MedDCM-OCT-S28-C15	29692-29723	9	0.719
NZ_CP049223_1	1.33\|393040\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	393040-393071	32	AP013671	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C48A-MedDCM-OCT-S33-C18, * SEQUENCING IN PROGRESS *	6420-6451	9	0.719
NZ_CP049223_1	1.33\|393040\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	393040-393071	32	AP013414	Uncultured Mediterranean phage uvMED DNA, complete genome, group G16, isolate: uvMED-CGR-C48A-MedDCM-OCT-S29-C21	22634-22665	9	0.719
NZ_CP049223_1	1.33\|393040\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	393040-393071	32	AP013672	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C48A-MedDCM-OCT-S38-C24, * SEQUENCING IN PROGRESS *	17507-17538	9	0.719
NZ_CP049223_1	1.33\|393040\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	393040-393071	32	AP013415	Uncultured Mediterranean phage uvMED DNA, complete genome, group G16, isolate: uvMED-CGR-C48A-MedDCM-OCT-S37-C22	19904-19935	9	0.719
NZ_CP049223_1	1.34\|393101\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	393101-393132	32	MN693872	Marine virus AFVG_250M911, complete genome	64918-64949	9	0.719
NZ_CP049223_1	1.34\|393101\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	393101-393132	32	MN693811	Marine virus AFVG_250M463, complete genome	5400-5431	9	0.719
NZ_CP049223_1	1.35\|393162\|33\|NZ_CP049223\|CRISPRCasFinder,CRT	393162-393194	33	NZ_CP009417	Jeotgalibacillus malaysiensis strain malaysiensis plasmid unnamed, complete sequence	544649-544681	9	0.727
NZ_CP049223_1	1.27\|392673\|32\|NZ_CP049223\|CRISPRCasFinder,CRT	392673-392704	32	NZ_CP016621	Microvirga ossetica strain V5/3m plasmid unnamed5, complete sequence	93247-93278	10	0.688

1. spacer 1.17|393100|33|NZ_CP049223|PILER-CR matches to MN693811 (Marine virus AFVG_250M463, complete genome) position: , mismatch: 7, identity: 0.788

tgaccaac-taaaagatttagcaggcatggtaaa	CRISPR spacer
-gtggaacgtaaaagatttaacaggcatgttaat	Protospacer
 *   *** ***********.******** ***

2. spacer 1.25|392551|32|NZ_CP049223|CRISPRCasFinder,CRT matches to NZ_CP017105 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence) position: , mismatch: 7, identity: 0.781

ggaaaacaacaatgcggactggaaaggcagat	CRISPR spacer
gggattcgccaatccggaatggaaaggcagat	Protospacer
**.*  *. **** **** *************

3. spacer 1.8|392550|33|NZ_CP049223|PILER-CR matches to MH248138 (Erwinia phage vB_EamM_Alexandra, complete genome) position: , mismatch: 9, identity: 0.727

tggaaaacaacaatgcggactggaaaggcagat	CRISPR spacer
tatcaaacaacaatccgaactggaaaggcgatc	Protospacer
*.  ********** **.***********.. .

4. spacer 1.11|392733|33|NZ_CP049223|PILER-CR matches to MT104474 (Pseudomonas phage MR14, complete genome) position: , mismatch: 9, identity: 0.727

taaaaggggtgattctgatgagttacacattta	CRISPR spacer
tatcgggggtgattctgatgagtgacgcagccg	Protospacer
**  .****************** **.** ...

5. spacer 1.17|393100|33|NZ_CP049223|PILER-CR matches to MN693872 (Marine virus AFVG_250M911, complete genome) position: , mismatch: 9, identity: 0.727

tgaccaactaaaagatttagcaggcatggtaaa	CRISPR spacer
ttggaatgtaaaagatttaacaggcatgttaat	Protospacer
* .  *  ***********.******** ***

6. spacer 1.23|392428|32|NZ_CP049223|CRISPRCasFinder,CRT matches to MH341452 (Listeria phage PSU-VKH-LP040, complete genome) position: , mismatch: 9, identity: 0.719

atagcttgcttgcactgcacctttagcgagtg	CRISPR spacer
gttagttgattgcaccgcacctttagcgccag	Protospacer
.* . *** ******.************   *

7. spacer 1.23|392428|32|NZ_CP049223|CRISPRCasFinder,CRT matches to DQ003637 (Listeria phage A500, complete genome) position: , mismatch: 9, identity: 0.719

atagcttgcttgcactgcacctttagcgagtg	CRISPR spacer
gttagttgattgcaccgcacctttagcgccag	Protospacer
.* . *** ******.************   *

8. spacer 1.23|392428|32|NZ_CP049223|CRISPRCasFinder,CRT matches to KP399678 (Listeria phage vB_LmoS_293, complete genome) position: , mismatch: 9, identity: 0.719

atagcttgcttgcactgcacctttagcgagtg	CRISPR spacer
gttagttgattgcaccgcacctttagcgccag	Protospacer
.* . *** ******.************   *

9. spacer 1.25|392551|32|NZ_CP049223|CRISPRCasFinder,CRT matches to MH248138 (Erwinia phage vB_EamM_Alexandra, complete genome) position: , mismatch: 9, identity: 0.719

ggaaaacaacaatgcggactggaaaggcagat	CRISPR spacer
atcaaacaacaatccgaactggaaaggcgatc	Protospacer
.  ********** **.***********.. .

10. spacer 1.28|392734|32|NZ_CP049223|CRISPRCasFinder,CRT matches to MT104474 (Pseudomonas phage MR14, complete genome) position: , mismatch: 9, identity: 0.719

aaaaggggtgattctgatgagttacacattta	CRISPR spacer
atcgggggtgattctgatgagtgacgcagccg	Protospacer
*  .****************** **.** ...

11. spacer 1.32|392979|32|NZ_CP049223|CRISPRCasFinder,CRT matches to NZ_CP017185 (Enterobacter roggenkampii strain DSM 16690 plasmid pDSMZ16690, complete sequence) position: , mismatch: 9, identity: 0.719

acgccgttgagatgatagaaagcgacttcaat	CRISPR spacer
tttgcggccagatgatagaaatcgactttaat	Protospacer
 .  ** . ************ ******.***

12. spacer 1.33|393040|32|NZ_CP049223|CRISPRCasFinder,CRT matches to NZ_CP016596 (Bacillus cereus strain K8 plasmid pBCM301, complete sequence) position: , mismatch: 9, identity: 0.719

gttgcgaagtcagtattagatgctttaaatcc	CRISPR spacer
gcaaccaagatagtattagatgctttaaaagt	Protospacer
*. .* *** .******************  .

13. spacer 1.33|393040|32|NZ_CP049223|CRISPRCasFinder,CRT matches to AP013413 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G16, isolate: uvMED-CGR-C48A-MedDCM-OCT-S28-C15) position: , mismatch: 9, identity: 0.719

gttgcgaagtcagtattagatgctttaaatcc	CRISPR spacer
gctatcaagtcagtattagaagcttttaacga	Protospacer
*.*.. ************** ***** **.

14. spacer 1.33|393040|32|NZ_CP049223|CRISPRCasFinder,CRT matches to AP013671 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C48A-MedDCM-OCT-S33-C18, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.719

gttgcgaagtcagtattagatgctttaaatcc	CRISPR spacer
gctatcaagtcagtattagaagcttttaacga	Protospacer
*.*.. ************** ***** **.

15. spacer 1.33|393040|32|NZ_CP049223|CRISPRCasFinder,CRT matches to AP013414 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G16, isolate: uvMED-CGR-C48A-MedDCM-OCT-S29-C21) position: , mismatch: 9, identity: 0.719

gttgcgaagtcagtattagatgctttaaatcc	CRISPR spacer
gctatcaagtcagtattagaagcttttaacga	Protospacer
*.*.. ************** ***** **.

16. spacer 1.33|393040|32|NZ_CP049223|CRISPRCasFinder,CRT matches to AP013672 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C48A-MedDCM-OCT-S38-C24, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.719

gttgcgaagtcagtattagatgctttaaatcc	CRISPR spacer
gctatcaagtcagtattagaagcttttaacga	Protospacer
*.*.. ************** ***** **.

17. spacer 1.33|393040|32|NZ_CP049223|CRISPRCasFinder,CRT matches to AP013415 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G16, isolate: uvMED-CGR-C48A-MedDCM-OCT-S37-C22) position: , mismatch: 9, identity: 0.719

gttgcgaagtcagtattagatgctttaaatcc	CRISPR spacer
gctatcaagtcagtattagaagcttttaacga	Protospacer
*.*.. ************** ***** **.

18. spacer 1.34|393101|32|NZ_CP049223|CRISPRCasFinder,CRT matches to MN693872 (Marine virus AFVG_250M911, complete genome) position: , mismatch: 9, identity: 0.719

gaccaactaaaagatttagcaggcatggtaaa	CRISPR spacer
tggaatgtaaaagatttaacaggcatgttaat	Protospacer
 .  *  ***********.******** ***

19. spacer 1.34|393101|32|NZ_CP049223|CRISPRCasFinder,CRT matches to MN693811 (Marine virus AFVG_250M463, complete genome) position: , mismatch: 9, identity: 0.719

gaccaactaaaagatttagcaggcatggtaaa	CRISPR spacer
tggaacgtaaaagatttaacaggcatgttaat	Protospacer
 .  *  ***********.******** ***

20. spacer 1.35|393162|33|NZ_CP049223|CRISPRCasFinder,CRT matches to NZ_CP009417 (Jeotgalibacillus malaysiensis strain malaysiensis plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.727

caacgcttacttcaaagtaataaagtcacttta	CRISPR spacer
cgtccagcacttcaaaataataaagtaactttt	Protospacer
*. *   .********.********* *****

21. spacer 1.27|392673|32|NZ_CP049223|CRISPRCasFinder,CRT matches to NZ_CP016621 (Microvirga ossetica strain V5/3m plasmid unnamed5, complete sequence) position: , mismatch: 10, identity: 0.688

agacgcacttacgcaaagtatgacttactttt	CRISPR spacer
ggtgacacttacgcacagcatgacttacgcac	Protospacer
.*  .********** **.********* . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

417185 : 464440

Lactobacillus_prophage(33.33%)

terminase,capsid,head,tRNA,portal,integrase,tail

attL 413588:413603|attR 455721:455736

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
413588:413603	attL	NA	NA	NA	NA
WP_164798666.1\|417185_417662_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	NA	NA	NA	NA
WP_006735497.1\|417739_418273_-	exonuclease	M1PFD8	Streptococcus_phage	7.5e-21	36.5
WP_006730662.1\|418386_419301_+	UDP-N-acetylmuramate dehydrogenase	NA	NA	NA	NA
WP_006733620.1\|419355_420462_+	ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	1.5e-34	43.3
WP_006737324.1\|420448_421261_+	ABC transporter permease	NA	NA	NA	NA
WP_164798667.1\|421257_422058_+	ABC transporter permease	NA	NA	NA	NA
WP_164798668.1\|422054_423128_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_006729026.1\|423166_424009_+	TIGR00159 family protein	NA	NA	NA	NA
WP_164798669.1\|424005_424974_+	hypothetical protein	NA	NA	NA	NA
WP_006729028.1\|424997_426350_+	phosphoglucosamine mutase	NA	NA	NA	NA
WP_006729029.1\|426540_428352_+	glutamine--fructose-6-phosphate transaminase (isomerizing)	Q76DQ7	Chlorella_virus	1.3e-96	38.2
WP_006736808.1\|428458_429982_+	membrane protein	NA	NA	NA	NA
WP_006736809.1\|429997_430396_+	CrcB family protein	NA	NA	NA	NA
WP_006729032.1\|430395_430746_+	protein CrcB	A0A2H4PQR0	Staphylococcus_phage	1.6e-11	38.8
WP_006731168.1\|430797_431670_-	zinc ABC transporter solute-binding protein	NA	NA	NA	NA
WP_006729034.1\|431982_432714_+	YebC/PmpR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_006730667.1\|432783_434019_-	cytosine deaminase	NA	NA	NA	NA
WP_006732241.1\|434030_435290_-	cytosine permease	NA	NA	NA	NA
WP_006731149.1\|435473_435920_-	DUF3021 domain-containing protein	NA	NA	NA	NA
WP_006729038.1\|435916_436348_-	LytTR family transcriptional regulator	NA	NA	NA	NA
WP_006734930.1\|436498_436990_+	acetyltransferase	NA	NA	NA	NA
WP_006731738.1\|445617_446592_+	Flp pilus assembly complex ATPase component TadA	NA	NA	NA	NA
WP_164798670.1\|446563_447559_+	type II secretion system protein F	NA	NA	NA	NA
WP_006729045.1\|447572_447899_+	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_080550276.1\|447882_448314_+	type II secretion system protein	NA	NA	NA	NA
WP_006729047.1\|448303_448522_+	hypothetical protein	NA	NA	NA	NA
WP_006736043.1\|448508_449000_+	competence protein ComGF	NA	NA	NA	NA
WP_164798671.1\|449247_450249_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_164798672.1\|450259_451471_+	acetate kinase	NA	NA	NA	NA
WP_006737660.1\|452022_453144_-\|integrase	tyrosine-type recombinase/integrase	Q6SEA7	Lactobacillus_prophage	2.0e-95	48.3
WP_006737543.1\|454290_454860_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_006729801.1\|455553_455742_+	addiction module toxin, HicA family	NA	NA	NA	NA
455721:455736	attR	NA	NA	NA	NA
WP_006729802.1\|455791_456187_+	antitoxin HicB	I3NLB2	Bifidobacterium_phage	1.3e-06	28.2
WP_164798673.1\|456291_456759_+\|terminase	small terminase subunit	A9D9R6	Lactobacillus_prophage	6.5e-45	59.5
WP_006738059.1\|456748_457978_+\|terminase	PBSX family phage terminase large subunit	A9D9R9	Lactobacillus_prophage	4.6e-138	58.7
WP_006732591.1\|457991_459422_+\|portal	phage portal protein	A0A0A1ER87	Lactobacillus_phage	2.8e-110	45.5
WP_006730975.1\|459414_461007_+\|capsid	minor capsid protein	Q6SED6	Lactobacillus_prophage	2.5e-43	32.6
WP_006730988.1\|461011_461296_+	hypothetical protein	NA	NA	NA	NA
WP_006730954.1\|461329_461821_+	hypothetical protein	NA	NA	NA	NA
WP_006730930.1\|461817_462075_+	hypothetical protein	NA	NA	NA	NA
WP_006730958.1\|462151_462412_+	hypothetical protein	NA	NA	NA	NA
WP_006738119.1\|462527_463133_+	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_006732598.1\|463146_464019_+	hypothetical protein	A0A0A1ELG8	Lactobacillus_phage	9.0e-80	55.7
WP_006730973.1\|464035_464440_+\|head,tail	phage head-tail connector protein	A0A097BY74	Leuconostoc_phage	5.0e-25	55.7

DBSCAN-SWA_2

577119 : 585416

Yellowstone_lake_phycodnavirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_006731699.1\|577119_578253_+	molecular chaperone DnaJ	A0A0P0YNN4	Yellowstone_lake_phycodnavirus	3.7e-25	27.4
WP_006731694.1\|578442_580281_+	elongation factor 4	E4ZFJ7	Streptococcus_phage	6.4e-19	24.0
WP_009310256.1\|580282_580969_+	class A sortase	NA	NA	NA	NA
WP_164798688.1\|580965_583251_+	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	1.6e-72	33.3
WP_164798689.1\|583346_583874_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	2.3e-22	39.7
WP_102695386.1\|583937_584894_+	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	1.3e-108	57.6
WP_006734110.1\|584915_585416_+	dihydrofolate reductase	G3MBI7	Bacillus_virus	6.4e-22	38.2

DBSCAN-SWA_3

643149 : 656783

unidentified_phage(12.5%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_006734094.1\|643149_644343_+\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	1.0e-41	46.3
WP_006729975.1\|644438_645104_-	hemolysin III family protein	NA	NA	NA	NA
WP_006732554.1\|645230_646082_+	DegV family protein	A0A0N9SI50	Staphylococcus_phage	8.1e-17	41.1
WP_006732550.1\|646090_646318_+	YozE family protein	NA	NA	NA	NA
WP_164798702.1\|646322_647705_+	S41 family peptidase	A0A0R6PIZ1	Moraxella_phage	3.3e-12	28.5
WP_006731946.1\|647918_648758_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_006731927.1\|648754_649507_+	ribonuclease HII	E3T5H8	Cafeteria_roenbergensis_virus	2.0e-27	39.6
WP_006732552.1\|649555_650401_+	DNA-protecting protein DprA	S6BFL3	Thermus_phage	8.3e-30	34.1
WP_006735030.1\|650470_652558_+	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	1.1e-94	35.5
WP_102695364.1\|652607_653921_+\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA
WP_164798703.1\|653923_654847_+	tyrosine recombinase XerC	A0A0K2CP59	Brevibacillus_phage	5.1e-25	27.2
WP_164798704.1\|654850_655375_+	HslU--HslV peptidase proteolytic subunit	NA	NA	NA	NA
WP_009310273.1\|655385_656783_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A1B2IEP8	Erwinia_phage	1.8e-29	24.4

DBSCAN-SWA_4

903232 : 924732

Streptococcus_phage(89.47%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000814511.1\|903232_903436_-	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_000857133.1\|903896_904127_-	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000804885.1\|904123_904546_-	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_001240982.1\|905345_908264_-\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	1.1e-169	36.1
WP_000576156.1\|908267_908822_-	recombinase family protein	A0A0F7LA37	Escherichia_phage	2.3e-36	52.1
WP_001038790.1\|909176_909914_-	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	E4ZFQ0	Streptococcus_phage	1.4e-134	99.6
WP_001814874.1\|910038_910122_-	23S rRNA methyltransferase attenuation leader peptide	NA	NA	NA	NA
WP_000336323.1\|910734_910902_-	conjugal transfer protein	D0R0F6	Streptococcus_phage	1.6e-14	68.0
WP_164798750.1\|911020_912940_-	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	99.2
WP_001791010.1\|912955_913072_-	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_001224320.1\|913316_914252_-	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	7.7e-170	99.0
WP_000769868.1\|914248_915250_-	peptidase P60	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_000804748.1\|915246_917424_-	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	100.0
WP_164798751.1\|917426_919874_-	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	99.6
WP_006731904.1\|919857_920364_-	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	2.5e-90	99.4
WP_164798752.1\|920338_920836_-	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	2.9e-91	99.4
WP_001009056.1\|920952_921174_-	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000398284.1\|921216_922422_-	XRE family transcriptional regulator	A0A1S5SEX3	Streptococcus_phage	2.8e-233	100.0
WP_000813488.1\|922601_923987_-	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.1e-265	100.0
WP_000985015.1\|924015_924402_-	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_000420682.1\|924417_924732_-	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0

DBSCAN-SWA_5

1060494 : 1071470

Bacillus_virus(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_006737851.1\|1060494_1062723_-	DNA helicase PcrA	A7KV33	Bacillus_phage	1.9e-129	41.7
WP_006729622.1\|1062824_1063436_-	glycoside hydrolase family 73 protein	A0A0A7RUS8	Clostridium_phage	6.6e-21	41.1
WP_164798792.1\|1063438_1064050_-	ECF transporter S component	NA	NA	NA	NA
WP_006729620.1\|1064265_1065408_-	guanosine monophosphate reductase	A0A1V0SHK8	Klosneuvirus	1.9e-61	32.4
WP_164798794.1\|1065555_1068219_-	cation-translocating P-type ATPase	A0A1J0FA34	Only_Syngen_Nebraska_virus	9.1e-75	30.1
WP_006729618.1\|1068403_1069240_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	3.7e-67	52.9
WP_006731299.1\|1069242_1070721_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	2.9e-107	44.3
WP_006729616.1\|1070771_1071470_-	glycosyl transferase	A0A2K9L2U7	Tupanvirus	1.4e-11	27.7

DBSCAN-SWA_6

1105948 : 1118942

Streptococcus_phage(37.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_006729584.1\|1105948_1106533_+	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	2.6e-51	51.8
WP_102215315.1\|1106631_1107897_-	AAA domain-containing protein	M1F3L1	Cronobacter_phage	1.3e-07	27.6
WP_164798805.1\|1107912_1109409_-	hypothetical protein	A0A191VYN2	Roseobacter_phage	1.1e-05	22.9
WP_035511949.1\|1109401_1110346_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	1.6e-45	37.1
WP_006729580.1\|1110345_1111380_-	YvcK family protein	A1IMD5	Streptococcus_phage	3.5e-91	52.7
WP_009310458.1\|1111392_1112268_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	7.8e-07	30.3
WP_164798807.1\|1112315_1115132_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	8.5e-297	54.8
WP_006733565.1\|1115159_1117157_-	excinuclease ABC subunit UvrB	NA	NA	NA	NA
WP_006736353.1\|1117214_1118942_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	7.6e-139	45.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP049224

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

16413 : 70394

Bacillus_virus(60.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_164798924.1\|16413_17328_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_164798925.1\|17425_18280_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_164798926.1\|18665_19925_+	M23 family metallopeptidase	Q6SEC2	Lactobacillus_prophage	1.6e-24	42.9
WP_164798927.1\|19938_20574_+	hypothetical protein	NA	NA	NA	NA
WP_006734920.1\|20573_21215_+	hypothetical protein	NA	NA	NA	NA
WP_164798928.1\|21349_22675_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	G3MB42	Bacillus_virus	2.3e-55	36.9
WP_164798929.1\|22993_23776_+	hypothetical protein	NA	NA	NA	NA
WP_164798930.1\|23855_27014_+	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_164798931.1\|27113_27551_+	hypothetical protein	NA	NA	NA	NA
WP_102215581.1\|27567_27819_+	hypothetical protein	NA	NA	NA	NA
WP_164798932.1\|28047_30891_+	type IV secretory system conjugative DNA transfer family protein	NA	NA	NA	NA
WP_164798933.1\|30892_32074_+	hypothetical protein	NA	NA	NA	NA
WP_006735178.1\|32163_32979_-	hypothetical protein	NA	NA	NA	NA
WP_157750144.1\|33049_33217_-	hypothetical protein	NA	NA	NA	NA
WP_164798934.1\|33427_34756_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	G3MB42	Bacillus_virus	5.6e-57	36.6
WP_164798935.1\|34830_36135_-	hypothetical protein	NA	NA	NA	NA
WP_164798936.1\|36330_37989_+	hypothetical protein	NA	NA	NA	NA
WP_006734626.1\|38726_40226_+	ATPase AAA	NA	NA	NA	NA
WP_164798937.1\|40522_40858_-	hypothetical protein	NA	NA	NA	NA
WP_164798938.1\|40863_42084_-	ParM/StbA family protein	NA	NA	NA	NA
WP_164798939.1\|42331_45892_+	VaFE repeat-containing surface-anchored protein	NA	NA	NA	NA
WP_164798940.1\|46039_47104_+	hypothetical protein	NA	NA	NA	NA
WP_164798941.1\|47122_48154_+	hypothetical protein	NA	NA	NA	NA
WP_164798942.1\|48155_49442_+	hypothetical protein	NA	NA	NA	NA
WP_006734630.1\|49572_50091_+	hypothetical protein	NA	NA	NA	NA
WP_164798943.1\|50244_51573_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	G3MB42	Bacillus_virus	2.5e-57	36.8
WP_006734667.1\|51859_52420_+	hypothetical protein	NA	NA	NA	NA
WP_006734660.1\|52556_52838_+	hypothetical protein	NA	NA	NA	NA
WP_164798944.1\|53063_54569_+	DUF3854 domain-containing protein	NA	NA	NA	NA
WP_164798945.1\|55051_55222_+	hypothetical protein	NA	NA	NA	NA
WP_164798946.1\|55387_56218_+	hypothetical protein	NA	NA	NA	NA
WP_145999006.1\|56313_57129_+	hypothetical protein	NA	NA	NA	NA
WP_102215560.1\|57159_58113_+	hypothetical protein	NA	NA	NA	NA
WP_164798947.1\|58242_58665_-\|transposase	IS200/IS605 family transposase	A0A0P0IQC6	Lactobacillus_phage	2.4e-30	46.2
WP_164798948.1\|58757_58928_+	hypothetical protein	NA	NA	NA	NA
WP_102215558.1\|59023_59242_+	hypothetical protein	NA	NA	NA	NA
WP_164798949.1\|59370_59790_+	hypothetical protein	NA	NA	NA	NA
WP_164798950.1\|59833_60208_+	hypothetical protein	NA	NA	NA	NA
WP_164798951.1\|60219_60555_+	hypothetical protein	NA	NA	NA	NA
WP_164798952.1\|60623_61676_+	hypothetical protein	NA	NA	NA	NA
WP_164798953.1\|61688_63938_+	hypothetical protein	NA	NA	NA	NA
WP_164798954.1\|63949_68428_+	type IV secretion system protein	NA	NA	NA	NA
WP_157750137.1\|68437_69157_+	hypothetical protein	NA	NA	NA	NA
WP_164798955.1\|69521_70394_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP049223

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP049224

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection