CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP021884	Sulfuriferula plumbiphila strain Gro7	4 crisprs	csa3,cas3,cas5,cas6e,cas2,DEDDh,DinG,WYL,cas8c,cas7,cas4,cas1	0	4	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP021884_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021884_1

1148298-1148383

Unclear

I-E

Consensus_repeat	Method
GTGTTCCCCGCACCCGCGGGGATGA	CRISPRCasFinder

1 spacers

cas2,cas6e,cas5

The CRISPR arrays of NZ_AP021884_1

>merge|NZ_AP021884|1|1148298-1148383|CRISPRCasFinder
GTGTTCCCCGCACCCGCGGGGATGAACCGCAGCCGCAGCCAATCGCCACGCAGCCTGTCAGGTGTTCCCCGCACCCGCGGGATGAG

>NZ_AP021884|1|1|1148298-1148383|CRISPRCasFinder
GTGTTCCCCGCACCCGCGGGGATGA	ACCGCAGCCGCAGCCAATCGCCACGCAGCCTGTCAG
GTGTTCCCCGCACCCGCGGGATGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021884.1\|WP_147070488.1\|1141914_1142286_-\|DUF202-domain-containing-protein	unknown	unknown	gnl\|CDD\|376882
NZ_AP021884.1\|WP_147070486.1\|1142295_1145139_-\|aconitate-hydratase-AcnA	unknown	unknown	gnl\|CDD\|236445
NZ_AP021884.1\|WP_147070475.1\|1148555_1149455_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|236338
NZ_AP021884.1\|WP_161984192.1\|1157869_1158085_+\|succinate-dehydrogenase-assembly-factor-2	unknown	unknown	gnl\|CDD\|377166
NZ_AP021884.1\|WP_147070492.1\|1138856_1139744_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_AP021884.1\|WP_147070490.1\|1139808_1141854_-\|methionine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234655
NZ_AP021884.1\|WP_147070472.1\|1149459_1151595_-\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NZ_AP021884.1\|WP_147070477.1\|1147906_1148203_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	pfam09707_cas2_CAS-I-E	gnl\|CDD\|236930
NZ_AP021884.1\|WP_147070460.1\|1157132_1157831_+\|succinate-dehydrogenase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|235652
NZ_AP021884.1\|WP_147070471.1\|1151614_1152046_-\|response-regulator	unknown	unknown	gnl\|CDD\|381103
NZ_AP021884.1\|WP_147070461.1\|1155369_1157133_+\|succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|181594
NZ_AP021884.1\|WP_147070467.1\|1153469_1154669_+\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|235976
NZ_AP021884.1\|WP_147070465.1\|1154672_1155050_+\|succinate-dehydrogenase,-cytochrome-b556-subunit	unknown	unknown	gnl\|CDD\|274370
NZ_AP021884.1\|WP_147070469.1\|1152139_1153207_-\|response-regulator	unknown	unknown	gnl\|CDD\|225971
NZ_AP021884.1\|WP_147070494.1\|1137963_1138608_-\|maleylacetoacetate-isomerase	unknown	unknown	gnl\|CDD\|273527
NZ_AP021884.1\|WP_147070480.1\|1146414_1146696_+\|prevent-host-death-protein	unknown	unknown	gnl\|CDD\|381342
NZ_AP021884.1\|WP_147070484.1\|1145195_1145732_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	gnl\|CDD\|273842
NZ_AP021884.1\|WP_147070482.1\|1145722_1146346_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09727_cas6e_CAS-I-E	gnl\|CDD\|187858
NZ_AP021884.1\|WP_147070463.1\|1155043_1155373_+\|succinate-dehydrogenase,-hydrophobic-membrane-anchor-protein	unknown	unknown	gnl\|CDD\|239574
NZ_AP021884.1\|WP_147070479.1\|1146692_1146992_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|368240

Protein	Function_ID	Function_description	E-value
NZ_AP021884.1\|WP_147070488.1\|1141914_1142286_-\|DUF202-domain-containing-protein	gnl\|CDD\|376882	pfam02656, DUF202, Domain of unknown function (DUF202). This family consists of hypothetical proteins some of which are putative membrane proteins. No functional information or experimental verification of function is known. This domain is around 100 amino acids long.	2.02704e-12
NZ_AP021884.1\|WP_147070486.1\|1142295_1145139_-\|aconitate-hydratase-AcnA	gnl\|CDD\|236445	PRK09277, PRK09277, aconitate hydratase AcnA.	0
NZ_AP021884.1\|WP_147070475.1\|1148555_1149455_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|236338	PRK08788, PRK08788, enoyl-CoA hydratase; Validated.	1.72253e-146
NZ_AP021884.1\|WP_161984192.1\|1157869_1158085_+\|succinate-dehydrogenase-assembly-factor-2	gnl\|CDD\|377166	pfam03937, Sdh5, Flavinator of succinate dehydrogenase. This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE. Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans. Bacterial homologs of Sdh5, termed SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterized as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria. This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true. The E. coli protein, YgfY also acts as the antitoxin to the membrane-bound toxin family Cpta, pfam13166, whose E. coli member YgfX, expressed from the same operon as YgfY.	9.95898e-08
NZ_AP021884.1\|WP_147070492.1\|1138856_1139744_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.18559e-35
NZ_AP021884.1\|WP_147070490.1\|1139808_1141854_-\|methionine--tRNA-ligase	gnl\|CDD\|234655	PRK00133, metG, methionyl-tRNA synthetase; Reviewed.	0
NZ_AP021884.1\|WP_147070472.1\|1149459_1151595_-\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	5.57807e-104
NZ_AP021884.1\|WP_147070477.1\|1147906_1148203_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|236930	PRK11558, PRK11558, putative ssRNA endonuclease; Provisional.	1.77998e-57
NZ_AP021884.1\|WP_147070460.1\|1157132_1157831_+\|succinate-dehydrogenase-iron-sulfur-subunit	gnl\|CDD\|235652	PRK05950, sdhB, succinate dehydrogenase iron-sulfur subunit; Reviewed.	3.24959e-160
NZ_AP021884.1\|WP_147070471.1\|1151614_1152046_-\|response-regulator	gnl\|CDD\|381103	cd17551, REC_RpfG-like, phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins. Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.53108e-26
NZ_AP021884.1\|WP_147070461.1\|1155369_1157133_+\|succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|181594	PRK08958, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NZ_AP021884.1\|WP_147070467.1\|1153469_1154669_+\|malate-dehydrogenase	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NZ_AP021884.1\|WP_147070465.1\|1154672_1155050_+\|succinate-dehydrogenase,-cytochrome-b556-subunit	gnl\|CDD\|274370	TIGR02970, Succinate_dehydrogenase_cytochrome_b556_subunit, succinate dehydrogenase, cytochrome b556 subunit. In E. coli and many other bacteria, two small, hydrophobic, mutually homologous subunits of succinate dehydrogenase, a TCA cycle enzyme, are SdhC and SdhD. This family is the SdhC, the cytochrome b subunit, called b556 in bacteria and b560 in mitochondria. SdhD (see TIGR02968) is called the hydrophobic membrane anchor subunit, although both SdhC and SdhD participate in anchoring the complex. In some bacteria, this cytochrome b subunit is replaced my a member of the cytochrome b558 family (see TIGR02046). [Energy metabolism, TCA cycle].	5.31774e-24
NZ_AP021884.1\|WP_147070469.1\|1152139_1153207_-\|response-regulator	gnl\|CDD\|225971	COG3437, COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms].	2.82376e-109
NZ_AP021884.1\|WP_147070494.1\|1137963_1138608_-\|maleylacetoacetate-isomerase	gnl\|CDD\|273527	TIGR01262, Maleylacetoacetate_isomerase, maleylacetoacetate isomerase. Maleylacetoacetate isomerase is an enzyme of tyrosine and phenylalanine catabolism. It requires glutathione and belongs by homology to the zeta family of glutathione S-transferases. The enzyme (EC 5.2.1.2) is described as active also on maleylpyruvate, and the example from a Ralstonia sp. catabolic plasmid is described as a maleylpyruvate isomerase involved in gentisate catabolism. [Energy metabolism, Amino acids and amines].	3.51034e-96
NZ_AP021884.1\|WP_147070480.1\|1146414_1146696_+\|prevent-host-death-protein	gnl\|CDD\|381342	cd19116, AKR_AKR2E1-5, AKR2E family of aldo-keto reductase (AKR). Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.	0.00952409
NZ_AP021884.1\|WP_147070484.1\|1145195_1145732_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	3.04148e-19
NZ_AP021884.1\|WP_147070482.1\|1145722_1146346_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|187858	cd09727, Cas6_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas6e. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6e is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-E subtype; Homologous to Cas6 (RAMP superfamily protein); Possesses double RRM/ferredoxin fold; also known as Cse3 family.	2.85934e-54
NZ_AP021884.1\|WP_147070463.1\|1155043_1155373_+\|succinate-dehydrogenase,-hydrophobic-membrane-anchor-protein	gnl\|CDD\|239574	cd03494, SQR_TypeC_SdhD, Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the high potential quinine, ubiquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type C SQRs because they contain two transmembrane subunits and one heme group. SdhD and SdhC are the two transmembrane proteins of bacterial SQRs. They contain heme and quinone binding sites. The two-electron oxidation of succinate in the flavoprotein active site is coupled to the two-electron reduction of quinone in the membrane anchor subunits via electron transport through FAD and three iron-sulfur centers. The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.	1.24047e-24
NZ_AP021884.1\|WP_147070479.1\|1146692_1146992_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	3.63668e-11

>NZ_AP021884.1|WP_147070477.1|1147906_1148203_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MLVIVLENVPPRLRGRLAIWLLEIRAGVYVGNYSDKVRDHIWHQVEVGIGEGNAVMAWRTSSEAGFDFVTLGKNRRIPVELDGAKLVSFLPQTDTDAL
>NZ_AP021884.1|WP_147070479.1|1146692_1146992_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MRYQVRFASAAADDLQRLFDFLAEQDLAAAERARAVISQAIEVLQIFPFSCRKASPENPFLRELVISFGSYGYVALFEVEDAESVTVLAVRHQREDDYH
>NZ_AP021884.1|WP_147070480.1|1146414_1146696_+|prevent-host-death-protein
MKNATLPPLRVESELRAAAESVLQEGETLSGFVLEAVRLNIARREAQREFITRGLVAREEAKLSGHYVSSDEMLKRLDASLAKARAKQAVGNR
>NZ_AP021884.1|WP_147070482.1|1145722_1146346_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MFLSRVEIPWDAARNPYNLHRQLWHLFPGEDRESRSSDDETRQGFLFRIEENATGRPARLLVQSRRAPTRANGLLLVGTREITPCPSAGQRLAFVLTANPVKTIVDAQRDAKPGKQSEKCRVPFIKEEEQRQWLLRKLGEAGEVEAVSVLPHAPVYFHKGSRAGKLVTATFEGVLRVRDPDRLAALLANGIGPAKAFGCGLLLVRRI
>NZ_AP021884.1|WP_147070484.1|1145195_1145732_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MFSREWPLLAESDIKPKTGKLGWTNSPAFSSCTRSWTARRAPITRTDLKARLECSSASLTSAHRRGAYLFDAAFTVAVGSKPGASVTLTQLAAALRQPLYTPSLGRRSCPLARPLLEGELEAEDALAALAKTAPVDGLVYSETQQSDQPLRLRDVPLHGHKRQFGTRLVYLHKDPTCS
>NZ_AP021884.1|WP_147070486.1|1142295_1145139_-|aconitate-hydratase-AcnA
MSTAHNLFNTLSEFTLGNGTPGRFYSLSALEAVGIGKISRLPVSIRIVLEAVLRNCDGRKITEQHIRELANWQPNGPRTEEIPFVVARILLQDFTGVPLLADLAAMRSAAAQAGKNPKVIEPLVPVDMVVDHSVQVDVFNQPDALQKNMELEFIRNRERYQFLKWGMQAFDTFKVVPPGIGIVHQVNLEYLARGVMEKDGVHYPDTLVGTDSHTTMINGLGIVAWGVGGIEAEAGMLGQPVYFLTPDVVGVHLKGQIREGVTATDVVLTVTEMLRKAKVVGKFVEFFGAGAAALSLPDRATIANMAPEYGATMGFFPVDEASCAYYAATGRSAEQVDTIRNYFMAQGLFGIPQAGDCDYSQELEIDLGSVVPSVAGPRRPQDRIELGHVKQAFAGLFAKPVAEGGYGKAAATLAQRVALAPAPAGTDIAGGGVQNSDTLPAGGTDPAVVIEREMVDNRPTPDHLASNAVYTAAQSGTLGHGDVVIAAITSCTNTSNPGVMLAAGLLAKKALEKGLTVPAHVKTSLGPGSRVVTEYLKAAGLLDALGEMGFKLVGYGCTTCIGNSGPLPAAIESAITGNDLIAASVLSGNRNFEARVHQNVKANFLMSPPLVVAYAIAGSMNTDLASEPLGTGRDGAPVYLKDIWPSLDEVAAVMATATNPDTYRKLYADFSADNPLWAAVPAPAGAVYDWDGASTYIRQPPFFDGAAGDSGVIRGARALAVFGDSVTTDHISPAGSIKPASPAGKFLLEHGVDRADFNSYGARRGNHEVMMRGTFANVRIRNLMLPGSEGGVTRHQPDGAEMAIYDAAMQYQAAGTPLMIFAGEEYGTGSSRDWAAKGTRLLGVKAVVAKSFERIHRANLVGMGVLPCQFRDGMGADSLKLDGSETFDLLGLEHGITPQQDITLVIHRADGSADAVAVKLRIDTPIEVDYYQSGGILPFVLAQLLAD
>NZ_AP021884.1|WP_147070488.1|1141914_1142286_-|DUF202-domain-containing-protein
MSDLNDPRVFFAAERTLLAWNRTCLTLMAFGFVVERFGLFLHMLAPQTPQHLERGISFWVGLGFILLGSLMAVLAVIQYRRVLRTLKPVEIPEGYWVNMAALSTLLLAVLGIVLSAYLTMGLK
>NZ_AP021884.1|WP_147070490.1|1139808_1141854_-|methionine--tRNA-ligase
MTRKILVTSALPYANGAIHLGHLVEYIQTDIWVRFQKMHGHECYYVCADDTHGTPIMLRAEKEGITPEQLIARVHGEHLRDFTGFHVGFDSYHSTNSGENRELSGTVYLKLREAGLIEQKTIEQYYDPVREMFLPDRFIKGQCPKCGAQDQYGDGCEVCGATYTPTDLINPVSAISGSTPVRRESEHYFFRLGACEAFLREWTRSGALQQEAANKLDEWFAAGLQNWDISRDAPYFGFEIPDAPGKYFYVWLDAPIGYMASFKKLAAEKNLDFDAWWQNDSGAELYHFIGKDILYFHALFWPAMLKNAGYRTPSGVFAHGFLTVNGAKMSKSRGTFITAESYLASGMDPEWLRYYYAAKINGSMEDLDLNLADFIARVNSDLVGKYVNIASRTAGFIARRFDGKLAARLPTSELLAEVQHAATLIGECYETREYGKALREIMRLTDLANQYVNDNKPWELAKQEGSEALLHEVCSVSVNLFRLLTLYLKPVLPRLATEVETFLNIAALAWVDAGTLLTSHSINAYSHLMTRVEQKQVDALVAANQQSLAASADAHSPARHAEAQNHVIAPIADTITADDFARIDLRVAKIVNAEHVEGADKLIRLTLDIGEGKTRNVFAGIKSAYDPEKLIGRMTVMVANLAPRKMKFGVSEGMVLAASGETAGLYILSPDDGAVPGMRVK
>NZ_AP021884.1|WP_147070492.1|1138856_1139744_+|LysR-family-transcriptional-regulator
MDIEQARTFLHVVAIGNFLGAAEKLHVTQSTVSARIQNLERKLGAKLFSRGKQGAALTAAGQRFVRHAQTLVRTADIAKQDVGLPDGYSGGLTVSGRIALWEGFLSRWVAWMRQAAPAISLRLEIGFEQDIMHGLVQNTLDIGLMYTPEARPGLGLERLFDETLVLVTTDRMRPWPDPGYVHVDWGTEFFHQFSLNFPDHPPPALSANVGWLGIQQLLTSGGSAYFPLRMVRTLLAKKRLHRVPGTPHFSVTAHMVYPLSRNDDFLQQALAGLRLLGREERRGQISMDTDNSPNP
>NZ_AP021884.1|WP_147070494.1|1137963_1138608_-|maleylacetoacetate-isomerase
MQLFSFFSSSTAFRVRIALALKGADYEYQAVNLRAGEQHQQAFLDRNPSGNVPALVDGDFNLGQSLAILDYLDSRYPEPRLIPADTIQRARVLELVNVIACDIHPVNNLRVQLYLKNILGVTEAQKNAWYRHWVAQGLDVVERLLARQEDTPYCFGTHPTLADCCLAPQVWSAARAGCDIAAYPRIDRIYRHCMAQPAFIQAAPEQQADAPQGG
>NZ_AP021884.1|WP_147070475.1|1148555_1149455_+|enoyl-CoA-hydratase/isomerase-family-protein
MNAVVEFQQFSNASLEQVRIRFDEEYGVMWSFMRPEPRPCFTRTTLQDLLQHHTYLESMKGRVVSNGNFQQTNYLILASDLQGVFNLGGDLAAFGEAIRAQTRKELLSYAKLCIDNVWTFYNLQAPITTISMVQGQAMGGGFEAALSAHVMIAEKSALMGLPEVLFNLFPGMGALSFLSRKIGMRAAEAMVRSGRVYTATELHEMGVVDVLAEDGQGEKTLYDWIRKNHRSLNSFQAIQRARQRVNPLTVEELYEITEIWVDAALRLSERDLRIMERLVRAQNRKVTEPEPVVAEQASA
>NZ_AP021884.1|WP_147070472.1|1149459_1151595_-|response-regulator
MLDKMKIWFTDRVAKCDRVELEQSLIRLGIGLAILVYLLYRYLTHTTLSHNDIVAFSILSVFLFLTLVLIGSILYSSKPSVVRRLAGAWVDQGGTTLFMAFTGEVGVMVVGVYLWVIFGNGFRFGRKYLIHAQVLSIVGFAITTQVNPYWDEHEAISYSVMLMLLALPIYVSALIRRMNEARQKAEEANAAKTRFVANMSHEIRTPLSGIIGISTLLKATPLNSEQQDLLGTLNSSSRLLVSLLNNVLDFAKIEDGKLAIEHTDFSVNSLLEETVKIFRSQAEAKSIRLDTHIAAAAGTLRGDPHRLQQVLANLVGNAVKFTERGSVTLSLSILGENEHHRNMRFEVADTGVGIPTSAQGKIFESFTQADISTTRRFGGSGLGLTITRHLVEAMGGRLSFESAEGLGSRFWFDLPLEKAVQAQPGSAEIVPLPATRDAGLENTLRILVCEDDATNQKILLRLLELAGHHVSLSANGEELLDQLEQSSFDLVIADLNMAGLSGTDALKLYRFTRADDTRTRFILFTADATLSARQAAKEAGFDAFLSKPVDASTLFGTIANLLGMPSASAEHWLNTVMGGSRSSPPASAETRAVLDAATLRELEILGAGDALFVQRLLRNYLRDSGELLDRIEHAVQQKQYGALRDHCHALKGNSLSIGARGVFGRAETIDRAGPGELRFRGSAMVGLLRTDYAAARAAIEDYLSRRQTAAR
>NZ_AP021884.1|WP_147070471.1|1151614_1152046_-|response-regulator
MSVRDIRSAPTYRQTVLIIDDQPMVLAIHTAVLKSLSMDLRIVSMTDPKAALEWLRQKPADLIVTDYRMHQMDGIHFVNAVRDSSIEPMRPIIVVTALKDEKIHQQLLAAGVSACLIKPARAAQLSKIARTLLEQSRRQYTTQ
>NZ_AP021884.1|WP_147070469.1|1152139_1153207_-|response-regulator
MTNFNLPDTSAVLILDDQATSRTILAQVVRSIGSGIRVQEETTPSAALAWAAAHPADLVLADYLMPDMNGVEFIGRLRQLPGYQHVPVVMVTIKQDMETRYAALDAGMTDFLTKPVDMRECLSRCRNLLTLRQQQLALEDKSRVLEDMVGQATEEIRCREKDTLMRLARAGEYRDTDTARHLLRMSRYSRVLADAIGLPEDEAELIELAAPLHDIGKIGIPDSILRKNGPLSDEELAIMRQHPKIGHDILEDSPSKYLRLGGEIALAHHERYDGSGYPFGTTGQDIPLSARIVAIADVFDALTSVRPYKSAWSIKSAMQYLLKESGRHFDPALVKAMLTLEASVEKIQEEHAEPG
>NZ_AP021884.1|WP_147070467.1|1153469_1154669_+|malate-dehydrogenase
MPTLKQQALDYHQFPKPGKLSVESSKPCATQHELSLAYSPGVAEPVRAIGADPELAYRYTNKGNLVAVITDGTAILGLGNLGPLAAKPVMEGKGVLFKRFANIDVFDIEVNAPSVQAFIDTVVNIAPTFGGINLEDIAAPHCFEIEKALSERLDIPVFHDDQHGTAVIICAGLINALHVQGKKLADARIVCLGAGAAGNASLRLLLAMGADKSRLLVVDKVGVLHTGMIDLPPHHAFFAADTDARTLADAMQGADAFIGVSAANLVTPAMIKSMADKPVVFALANPDPEIAPHDVHAARDDAIIATGRSDYPNQVNNILGFPFIFRGALDARAKRITQKMLIAAVHALMDLAREPVPADVLAIYNLTELAFGRDYILPKPFDARLIERIPPAVMKAAKE
>NZ_AP021884.1|WP_147070465.1|1154672_1155050_+|succinate-dehydrogenase,-cytochrome-b556-subunit
MRHPSRPVYLNIFKIHLPLPGWMSILQRMSGAVLFLVTPLLLYLLQTSFDADGYARLREWLHIPVVKALSTLLLWGYLLHLLGGLRFLLLDIHVGTALATARKLSAATLLASALLTLVIAGIGLW
>NZ_AP021884.1|WP_147070463.1|1155043_1155373_+|succinate-dehydrogenase,-hydrophobic-membrane-anchor-protein
MVGGALSAWLVQRVSALLLAAYALFFPVWVALHWPLDFAVWRGLFAPLPMRIVTLLFVVALALHAWVGMRDIFMDYVQPLGLRLALHVGALLWLATCVVWAGAVLWSLP
>NZ_AP021884.1|WP_147070461.1|1155369_1157133_+|succinate-dehydrogenase-flavoprotein-subunit
MMPVKRKFDAVIVGGGGAGLRAALQLSGSGLQVAVVSKVFPTRSHTVSAQGGITAALGNVTPDNWHWHMYDTVKGSDYLGDQDAIEFMCRHAAEAVIELEHMGLPFSRLDNGRIYQRAFGGQSMNYGGEQATRTCAAADRTGHALLHTLHQQNLKAHTHFFDEYFALDLLRDADGYVLGVTALCIETGAPLVIEARATLLATGGAGRIFRYSTNAHINTGDGLGMVLRAGLALQDMEFWQFHPTGLPGSGSLITEGVRGEGGYLVNNQGERFMERYAPHAKDLAGRDVVARALALEIHAGRGCGPHGDTIHLKLDHLGAALIKDKLPGIRELALRFAGVDPIDAPIPVVPTAHYMMGGIPTDLHGQVVMPARFGPEEPVPGLYAVGECACVSVHGANRLGGNSLLDLVVFGRAAGNHIIETLRDNPFPRLLPESAAEAALARLARWNKTGAGESVAELRLALQTLMQKHCGVFRTETLMGEGIAALDILQARLDNARLADHSQVFNTARIEALELENLFAVARATLVSAHARTESRGAHAREDYPERDDGHWLKHTLYTRENDQIDTKPVRLKPLTVEPFLPKERIY
>NZ_AP021884.1|WP_147070460.1|1157132_1157831_+|succinate-dehydrogenase-iron-sulfur-subunit
MRFSIYRYDPEHDTKPHMQAYDVDIEPAGNMLLDALLRIKDTLDSTLTLRRSCREGVCGSDGMNINGSNGLACITPLADLRQPVEVRPLPGLPVIRDLVVDMTPFNQQYRSVEPWLNNADPAPEIERLQSPEQRAQLDGLVECIQCGCCSSACPSFWWNPDKFVGPAGLLAAYRFIADSRDQGANQRLDNLQDPYRLFRCHGIMNCVSVCPKGLNPTAAIGKIKTLLVKRGA
>NZ_AP021884.1|WP_161984192.1|1157869_1158085_+|succinate-dehydrogenase-assembly-factor-2
MLELDILLLDFLEQQYPVLPSSQQIAFGALLELGDSELWDMIQTGQSAAQPEQAKIIEWLRTGKQKNESTD

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Crispr_ID: NZ_AP021884_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021884_2

1831685-1831793

Orphan

Consensus_repeat	Method
GGCAGCATCACGCCTATCCAGGCCAGTCCCGGTGCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021884_2

>merge|NZ_AP021884|2|1831685-1831793|CRISPRCasFinder
GGCAGCATCACGCCTATCCAGGCCAGTCCCGGTGCGACTTGCGTTGGATACCTCATCCTCATCATTGCGCTGGCAGCATCACGCCTATCCAGGCCAGTCCCGGTGCGAC

>NZ_AP021884|2|2|1831685-1831793|CRISPRCasFinder
GGCAGCATCACGCCTATCCAGGCCAGTCCCGGTGCGAC	TTGCGTTGGATACCTCATCCTCATCATTGCGCT
GGCAGCATCACGCCTATCCAGGCCAGTCCCGGTGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021884.1\|WP_147074728.1\|1834121_1835225_-\|nickel-dependent-hydrogenase-large-subunit	unknown	unknown	gnl\|CDD\|380187
NZ_AP021884.1\|WP_147074717.1\|1819887_1821237_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|236901
NZ_AP021884.1\|WP_147074716.1\|1818851_1819808_+\|HTH-type-transcriptional-regulator-CysB	unknown	unknown	gnl\|CDD\|237173
NZ_AP021884.1\|WP_147074733.1\|1837357_1837666_-\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	unknown	unknown	gnl\|CDD\|376549
NZ_AP021884.1\|WP_147074751.1\|1823172_1824168_-\|HupU-protein	unknown	unknown	gnl\|CDD\|224654
NZ_AP021884.1\|WP_147074724.1\|1830036_1830279_-\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	unknown	unknown	gnl\|CDD\|376549
NZ_AP021884.1\|WP_161984236.1\|1835224_1835764_-\|[NiFe]-hydrogenase-assembly-chaperone-HybE	unknown	unknown	gnl\|CDD\|378765
NZ_AP021884.1\|WP_161984237.1\|1836001_1836784_-\|hydrogenase-expression/formation-protein	unknown	unknown	gnl\|CDD\|377409
NZ_AP021884.1\|WP_147074734.1\|1837670_1838294_-\|HyaD/HybD-family-hydrogenase-maturation-endopeptidase	unknown	unknown	gnl\|CDD\|129246
NZ_AP021884.1\|WP_147074718.1\|1821238_1821706_-\|nickel-responsive-transcriptional-regulator-NikR	unknown	unknown	gnl\|CDD\|235093
NZ_AP021884.1\|WP_147074727.1\|1833787_1834129_-\|hydrogenase-maturation-nickel-metallochaperone-HypA	unknown	unknown	gnl\|CDD\|376468
NZ_AP021884.1\|WP_147074730.1\|1835770_1835986_-\|rubredoxin	unknown	unknown	gnl\|CDD\|238372
NZ_AP021884.1\|WP_147074732.1\|1836869_1837361_-\|hydrogenase	unknown	unknown	gnl\|CDD\|239263
NZ_AP021884.1\|WP_147074721.1\|1826161_1827847_-\|hydrogenase-maturation-protein	unknown	unknown	gnl\|CDD\|187719
NZ_AP021884.1\|WP_147074720.1\|1824193_1825636_-\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_AP021884.1\|WP_147074722.1\|1827848_1828904_-\|hydrogenase-expression/formation-protein-HypE	unknown	unknown	gnl\|CDD\|273984
NZ_AP021884.1\|WP_147074719.1\|1821718_1823176_-\|nickel-dependent-hydrogenase-large-subunit	unknown	unknown	gnl\|CDD\|380187
NZ_AP021884.1\|WP_147074726.1\|1832692_1833727_-\|hydrogenase-nickel-incorporation-protein-HypB	unknown	unknown	gnl\|CDD\|182479
NZ_AP021884.1\|WP_147074735.1\|1838453_1838801_-\|HigA-family-addiction-module-antidote-protein	unknown	unknown	gnl\|CDD\|225635
NZ_AP021884.1\|WP_147074723.1\|1828900_1830040_-\|hydrogenase-formation-protein-HypD	unknown	unknown	gnl\|CDD\|237892

Protein	Function_ID	Function_description	E-value
NZ_AP021884.1\|WP_147074728.1\|1834121_1835225_-\|nickel-dependent-hydrogenase-large-subunit	gnl\|CDD\|380187	NF033181, NiFeSe_hydrog, nickel-dependent hydrogenase large subunit. Members of this family are the large subunit of the periplasmic nickel-dependent hydrogenase. Some members contain a selenocysteine residue.	7.55916e-08
NZ_AP021884.1\|WP_147074717.1\|1819887_1821237_-\|PAS-domain-containing-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	1.71111e-46
NZ_AP021884.1\|WP_147074716.1\|1818851_1819808_+\|HTH-type-transcriptional-regulator-CysB	gnl\|CDD\|237173	PRK12684, PRK12684, CysB family HTH-type transcriptional regulator.	0
NZ_AP021884.1\|WP_147074733.1\|1837357_1837666_-\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	gnl\|CDD\|376549	pfam01455, HupF_HypC, HupF/HypC family.	8.42508e-16
NZ_AP021884.1\|WP_147074751.1\|1823172_1824168_-\|HupU-protein	gnl\|CDD\|224654	COG1740, HyaA, Ni,Fe-hydrogenase I small subunit [Energy production and conversion].	8.96139e-73
NZ_AP021884.1\|WP_147074724.1\|1830036_1830279_-\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	gnl\|CDD\|376549	pfam01455, HupF_HypC, HupF/HypC family.	7.20026e-30
NZ_AP021884.1\|WP_161984236.1\|1835224_1835764_-\|[NiFe]-hydrogenase-assembly-chaperone-HybE	gnl\|CDD\|378765	pfam11939, NiFe-hyd_HybE, [NiFe]-hydrogenase assembly, chaperone, HybE. Members of this family are chaperones for the assembly of [NiFe] hydrogenases, in the family of HybE, which is specific for hydrogenase-2 of Escherichia coli. Members often have an additional N-terminal rubredoxin domain.	2.70791e-59
NZ_AP021884.1\|WP_161984237.1\|1836001_1836784_-\|hydrogenase-expression/formation-protein	gnl\|CDD\|377409	pfam04809, HupH_C, HupH hydrogenase expression protein, C-terminal conserved region. This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown.	2.97673e-50
NZ_AP021884.1\|WP_147074734.1\|1837670_1838294_-\|HyaD/HybD-family-hydrogenase-maturation-endopeptidase	gnl\|CDD\|129246	TIGR00140, Hydrogenase_expression/formation_protein_HupD, hydrogenase expression/formation protein. valid names: hupD, hynC, hoxM. C at 64 and 67 are believed to be metal binding. Postulated to be involved in processing or hydrogenase. Superfamily suggests that it is a peptidase/protease. [Protein fate, Protein modification and repair].	1.51535e-65
NZ_AP021884.1\|WP_147074718.1\|1821238_1821706_-\|nickel-responsive-transcriptional-regulator-NikR	gnl\|CDD\|235093	PRK02967, PRK02967, nickel-responsive transcriptional regulator NikR.	6.69281e-65
NZ_AP021884.1\|WP_147074727.1\|1833787_1834129_-\|hydrogenase-maturation-nickel-metallochaperone-HypA	gnl\|CDD\|376468	pfam01155, HypA, Hydrogenase/urease nickel incorporation, metallochaperone, hypA. HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.	1.58556e-43
NZ_AP021884.1\|WP_147074730.1\|1835770_1835986_-\|rubredoxin	gnl\|CDD\|238372	cd00730, rubredoxin, Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are believed to be involved in electron transfer.	9.11972e-20
NZ_AP021884.1\|WP_147074732.1\|1836869_1837361_-\|hydrogenase	gnl\|CDD\|239263	cd02965, HyaE, HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the sole energy source. The E. coli HyaE protein is a chaperone that specifically interacts with the twin-arginine translocation (Tat) signal peptide of the [NiFe] hydrogenase-1 beta subunit precursor. Tat signal peptides target precursor proteins to the Tat protein export system, which facilitates the transport of fully folded proteins across the inner membrane. HyaE may be involved in regulating the traffic of [NiFe] hydrogenase-1 on the Tat transport pathway.	2.59879e-35
NZ_AP021884.1\|WP_147074721.1\|1826161_1827847_-\|hydrogenase-maturation-protein	gnl\|CDD\|187719	cd08650, FMT_core_HypX_N, HypX protein, N-terminal hydrolase domain. The family represents the N-terminal hydrolase domain of HypX protein. HypX is involved in the maturation process of active [NiFe] hydrogenase. [NiFe] hydrogenases function in H2 metabolism in a variety of microorganisms, enabling them to use H2 as a source of reducing equivalent under aerobic and anaerobic conditions. [NiFe] hydrogenases consist of a large and a small subunit. The large subunit contains [NiFe] active site, which is synthesized as a precursor without the [NiFe] active site. This precursor then undergoes a complex post-translational maturation process that requires the presence of a number of accessory proteins. HypX has been shown to be involved in this maturation process and have been proposed to participate in the generation and transport of the CO and CN ligands. However, HypX is not present in all hydrogen-metabolizing bacteria. Furthermore, hypX deletion mutants have a reduced but detectable level of hydrogenase activity. Thus, HypX might not be a determining factor in the matur ation process. Members of this group have an N-terminal formyl transferase domain and a C-terminal enoyl-CoA hydratase/isomerase domain.	4.42793e-83
NZ_AP021884.1\|WP_147074720.1\|1824193_1825636_-\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	4.71178e-151
NZ_AP021884.1\|WP_147074722.1\|1827848_1828904_-\|hydrogenase-expression/formation-protein-HypE	gnl\|CDD\|273984	TIGR02124, Hydrogenase_expression/formation_protein_HypE, hydrogenase expression/formation protein HypE. This family contains HypE (or HupE), a protein required for expression of catalytically active hydrogenase in many systems. It appears to be an accessory protein involved in maturation rather than a regulatory protein involved in expression. HypE shows considerable homology to the thiamine-monophosphate kinase ThiL (TIGR01379) and other enzymes.	1.16732e-176
NZ_AP021884.1\|WP_147074719.1\|1821718_1823176_-\|nickel-dependent-hydrogenase-large-subunit	gnl\|CDD\|380187	NF033181, NiFeSe_hydrog, nickel-dependent hydrogenase large subunit. Members of this family are the large subunit of the periplasmic nickel-dependent hydrogenase. Some members contain a selenocysteine residue.	8.05841e-130
NZ_AP021884.1\|WP_147074726.1\|1832692_1833727_-\|hydrogenase-nickel-incorporation-protein-HypB	gnl\|CDD\|182479	PRK10463, PRK10463, hydrogenase nickel incorporation protein HypB; Provisional.	1.47349e-134
NZ_AP021884.1\|WP_147074735.1\|1838453_1838801_-\|HigA-family-addiction-module-antidote-protein	gnl\|CDD\|225635	COG3093, VapI, Plasmid maintenance system antidote protein [General function prediction only].	4.41935e-27
NZ_AP021884.1\|WP_147074723.1\|1828900_1830040_-\|hydrogenase-formation-protein-HypD	gnl\|CDD\|237892	PRK15062, PRK15062, hydrogenase isoenzymes formation protein HypD; Provisional.	0

>NZ_AP021884.1|WP_147074724.1|1830036_1830279_-|HypC/HybG/HupF-family-hydrogenase-formation-chaperone
MCLALPARIVEMRKQDIGIVDLGGVRKEVSLALVDDLQVDDYVIVHVGYALSKLDPEEAERTLRIFAEMESMPGNVGVGA
>NZ_AP021884.1|WP_147074723.1|1828900_1830040_-|hydrogenase-formation-protein-HypD
MKYVDEFRDGELANGLASTIARAADTGRNYSFMEFCGGHTHAISRYGVTDLLPANIQMIHGPGCPVCVLPIGRIDLAIGLALDQGVILCTYGDTLRVPASDGLSLMKAKARGGDVRMIYSTADVLAIARDNPDRDVVFLAIGFETTTPPTALLIEQAKNEGIGNLSVLCNHVLTPSAITHILESPEVREYGTLPLDGFIGPSHVSTVIGTQPYEHFAREYRKPVVISGFEPLDVMQGILMLVRQVNEGRAEVENEFFRAVTRGGNRKAQTLVAKIFELRRTFEWRGLGEVPYSALQIRSEYAAFDAEQRYGLRYAPVADNKACECGAILRGVKKPTDCKIFGTVCTPETPMGSCMVSSEGACAAHYTYGRFKDVEIVAA
>NZ_AP021884.1|WP_147074722.1|1827848_1828904_-|hydrogenase-expression/formation-protein-HypE
MSTVKPGYTRPLDVRNGRIDLSHGGGGRAMAQLIEELFAAAFDNEYLAQGNDGAVLAMPSAGGRLVMATDAHVVSPLFFPGGDIGCLSVHGTVNDVAVMGARPLWLAASFVLEEGFPLSDLKRIVESMANAAKSAGVSVVTGDTKVVERGKGDGVFITTTGVGVLPKGLDLSGNKATPGDVILLSGTIGDHGMAIMSKRENLAFDAPIESDTAALHGLVADMLASGSGIRVLRDPTRGGLATTLNEIAKQSGVGMQLDESSIPVRPVVDAACEFLGLDPLYIANEGKLVAICAPEDAGGLLAVMRAHPLGRESAIIGTVHADPHHFVQMKTRFGGRRNVDWLSGEQLPRIC
>NZ_AP021884.1|WP_147074721.1|1826161_1827847_-|hydrogenase-maturation-protein
MRILFLTHSFNSLTQRLYVALTELGHEVSVEFDIADSVTEEAVALYRPDIILAPFLKRAIPASVWRHHTCLVVHPGIVGDRGPSALDWAVQNAETEWGVTVLQANAVMDGGDIWANEIFPMRLAKKSSLYRNEVTEAATRAVTTAIERYAQRDFVPCPLEKWSNVAGQERPVMWQEDRRINWLRDDTQTILRRIHAADGFPGVRDSLFDHACFLFDAHAAPDYSGAPGTILGWQGTSLVRATVDGAIRIGHVRRPESAHPFKLPALVAFAAEQASIPVLCEADGESIRYEEQDGVGYLYFDFYNGAMSTAQCRELLAAYRQACSRPTRVIVLMGGDDFWSNGIHLNLIEASEHPAEESWENIQAMDDLAEAIITATSHITVSALANNAGAGGAFLALAADHVWARPSVLLNLHYKNMGNLYGSEFWTYTLPRRVGLEKTSRIVENRLPMSARQAARLGIVDACFGTDAAMFRREVKQRATAISRSPDYDVLRKTKTEARDRDESEKPLLRYRESELSEMHRNFFGFDPSYHYARRYFVHKTLPAWTPRHLCKHRGMVQGNH
>NZ_AP021884.1|WP_147074720.1|1824193_1825636_-|sigma-54-interacting-transcriptional-regulator
MSLPTVLIVDDEIRSLEALRRTLEEDFTVFTASNVDAALEILRQEFIQIIVCDQRMPVQSGVTFLKHVRADWPDVVRIMLSGYTDTEDIIAGINEAGIFQYLLKPWQPEQLMLVLRSAADVYRLQLENQRLSLELRDSPALLAERVANKRQHVREKFSLDRVARAPDSPLNATCEMIDRIAPYDISVLITGESGTGKELLAHALHYRSGRAAQAFVTQNCGALPDALLEAELFGYKRGAFTGAYSDRVGLFQQADGGTIFLDEIGETTPSFQVKLLRVLQEGEIRPLGSPRSVQVNVRVIAATNRDLEEEVRAGRLRQDLYYRIANLTMHLPPLRERPMDIPLIAEGLLQRAMRQLNRKVRGFTPETLDCFKAYRWPGNVRELQNEILRILALTDSEWLEARLLSPKVLRAAMEESEEQQLDLLAGLDGSLKDRMEQLEARLIRETLIRHRWNKTHAAQELGLSRVGLRSKLVRYGMDKT
>NZ_AP021884.1|WP_147074751.1|1823172_1824168_-|HupU-protein
MNLIWLQSGGCGGCTMSLLSADVRDLFGMLKDAGINIVWHPGLSEQTGSEAIEVLEACASGDLPLDILCVEGSLLRGPNGTGRFHVLSGTGKPMIEWVRQLAEKAQYTIAVGTCATYGGVTAGGCNPTDACGMQYDGASRGGLLGVDYLSQSGLPVINIAGCPTHPGWVLETLLALAMDSFTQADLDELGRPRFYADHLVHHGCARNEYYEFKASAEKPSDQGCMMENMGCKGTQAHADCNIRPWNGGGSCTDGGYACIGCTEPGFEEPGHPFTQTPKIAGIPIGLPTDMPKAWFVALATLSKSATPKRVKENATSDHLVIVPGIRKTGVK
>NZ_AP021884.1|WP_147074719.1|1821718_1823176_-|nickel-dependent-hydrogenase-large-subunit
MSRLVVGPFNRVEGDLEVTLDISGGRVDRAYVDSTLYRGFEQILRGKDPMDALVFVPRICGICSVTQSVAAANALRNAMGISIPRNGQLATNLILANENLTDHFTHFYLFFMPDFARDGYSGRPWHGMAEQRFKAVTGSAAGDALPARAAFLHMMGVLAGKWPHTLTLQPGGSSRAVSSTEKIRLYAMLREFRAYLEKIMFGDKLENIVKLDSMRALEAWRDARPPDASDFRLFLEVARDLELHRIGRATDIFLSYGSYEMAGEYLFSPGVWDASKGTLSAIDPSDIVEDLSHSRMTGERDARHPYQGETQPAPDKPDAYTWCKAPRWRGQVLECGALARQVVTGHPLIRDMVEKTGGNVTTRVVARLLEISRVIPAMESWIKSLSPGEPFCVQGRMPDNAKGVGMVEAARGALGHWLVVKEGKIANYQIVAPTTWNFSPRDRDGIPGALEQALVGVPVGEHERVPLAVQHVVRSFDPCMVCTVH
>NZ_AP021884.1|WP_147074718.1|1821238_1821706_-|nickel-responsive-transcriptional-regulator-NikR
MERFTISLDEDLAQEFDRLILARGYSNRSEAVRDMLRAELEKSRQVRYEGTHCIAALSYVYNHHERELAERLTALQHDHHDLTVSTLHAHLDHDNCIECVVLRGKTAEVRDFAGKLIAERGVRHGNLSVITVSQEQHKHRHGLFARSHIHYKPHN
>NZ_AP021884.1|WP_147074717.1|1819887_1821237_-|PAS-domain-containing-protein
MFSKTGLLSLPDMPIEGVGEQFWMEVIRKMDEVYSDLLKYQTALEEQNNKLEESQQFIFGVLAAMSDILVVCDQTGTIEDVNQSLIELTGKTSAEWRGHPLVELFADDISRKQAELKFNGLQGQAIHDCEMQIRMANGSSMPVSVNCTARFNKKGKSVGMVITGRPVGELRRAYHALQEAHEALKRTQQQLVHSEKMASLGRLVAGVAHELNNPISFVLGNVHVLERYAGRLKEYLDAVHAGRSGIELAELREKLKIDRILGDIRPLIEGTIEGAERTRDIVDGLKRFSAIDREEECEFNLVEIIQRAVHWVTNITSESFQVEMDLPHFIPVLGSAAQIQQVIMNLVQNAVDATAEVKSPRLRIQAKIEKDKAVVEFRDNGSGILPENFPKIFDPFFTTKPVGKGTGLGLAISYGIVERHNGALFAANDAHDGGTIFVLNLPLYQSAKN
>NZ_AP021884.1|WP_147074716.1|1818851_1819808_+|HTH-type-transcriptional-regulator-CysB
MKIQQLRYLHEVARQGLNVSLAAEKLHTSQPGVSKQIQLLEEELGVDILVRHGKRVTGITEPGQKILAITERILREAENLKRVGADFTNETHGSLSIATTHTQARYALPSVIKTFSERYPGVQLRLHQGNPAQIVEMVLSGEADIAIATEAIALHDELVTLPCYQWNRCVIVQPDHPLLGEPTLTLERIADYSIITYDFAFAGRSQINKAFMERNLSPNVVLTAIDADVIKTYVGIGLGIGIMASMAFDPGRDQNLRAIDASHLFEPSTTRIGIRQGTYLRGYTFEFIQMFAPHLNHEAVNMAISAACRSAHQEAPKI
>NZ_AP021884.1|WP_147074726.1|1832692_1833727_-|hydrogenase-nickel-incorporation-protein-HypB
MCTTCGCSAGETRIEGQAMDGHSHVHADGTVHDHRHEAPAADGKMQYHAHHDENAHGHRHADGTWHSHDHGHEGEHVHEHGEDVIDYGQGPAHAHAPGLTQSQMVRIEQDILGKNNAYAGRNRNYFDEHGIFALNLVSSPGSGKTTLLVRTIETLKSRIQVAVVEGDQQTSQDAERIRSTGVRALQINTGKGCHLDANMVGHALERLHPEDDSVLMIENVGNLVCPAAYDLGEAHKVVILSVTEGEDKPLKYPDMFRAASLMLLNKTDLLPYVPFNVQLAIEYAKQVNPGLHIIQTSSTNGDGYEAWLGWIETGLARQRKKRAQTVAVLQKRIQELEAHLAARG
>NZ_AP021884.1|WP_147074727.1|1833787_1834129_-|hydrogenase-maturation-nickel-metallochaperone-HypA
MHEMSLAEGVLQILEDTATHHGFQQIKRVRLEIGELACVEVESLRFCLDVVVRGSVAENTMLDIVQTPGGGWCMNCSDTVPISALFSACPRCGSYQVQPTHGTEMRVLELEGV
>NZ_AP021884.1|WP_147074728.1|1834121_1835225_-|nickel-dependent-hydrogenase-large-subunit
MSLAGKLTFSVGWDGYRVTSVEVRSSRPQAACLLEGKTVEEAMRLVPLLFGICGKAQTVAARSAAQAAQNLCGDKQLMLRQRRLVALEAAQEHLWRLLVDWPNRLGLPAKQGLMMEWVKRISISRGDDDVLALGEAMLTMIEQDVLDESLDCWAATLERAERTPMRGLAGASLEMLRGLEPLHSGHPVFGHFLPRQAACLWGNELQPYLDGHFAVRPLWRNAPAEAGALALHHQIPLLAELLRTGHAASARYLARLVDWVSCVRLLRGEASSTELRLDACKLGKNAGLACVDTARGLLLHYIEVALGQIVRYVIVAPTEWNFHPAGPFVQTLRSLRADDAASLYQRINILILAFDPCVEYEVNLHHA
>NZ_AP021884.1|WP_161984236.1|1835224_1835764_-|[NiFe]-hydrogenase-assembly-chaperone-HybE
MKLMNPRPLENPSRMIESVFDGIARHRMAGLPILNPSLHVEAVGFRLWEGLWLGILITPWTINLMLLPADNPDYAALGLGETRRWRFPSGQYDFMGGEEPGLGSYQACSLFSPVFEFASQEDAVATARAALEQLLLEDLEAAVKREKAQWDQARFSDAPLAEQALSRRGFLRGAFLRDP
>NZ_AP021884.1|WP_147074730.1|1835770_1835986_-|rubredoxin
MDTFEGSYLGHDDRIDESVRLECGICWLVYDPEVGDPYWHIPPGTPFSRLPEHWTCPNCDAPRHKFMVLKD
>NZ_AP021884.1|WP_161984237.1|1836001_1836784_-|hydrogenase-expression/formation-protein
MNMPKGMAVFNPPSVPDDVAPELRDQAANLIRQLLAQMRAYRFGATSYPKIDLLKYDPRVVPLINDILGQGEVSIIAHQPTALRAQETVFASVWRVCYPGADGVLERDYLEVCPIPAVVAEIALAPTLKQISPPPPPAGAMNSPALLHEILDVVSTYQAGNPAHIINLTLLPLTPDDLAYLVQALGPGSVSILSRGYGNCRITSSGLANVWWVQYFNSSDQLILNTIEVVEVPEVALAAEEDFSDSIERVEEWLGTMLAA
>NZ_AP021884.1|WP_147074732.1|1836869_1837361_-|hydrogenase
MSEGVLDYALVAQEKVATEQNALGMLITRLCEQHQFVLVDEGNLEALTQASGDMVLLLTEDVVRSPETWDVAIVLPEILKLFGGRLKAAIADTENSKKLQARFGTTRFPAMVFLRDGEYVDVIQRMLDWDEFVAEVTGVLEKPIGRAPTIGIPVRNEVASSCH
>NZ_AP021884.1|WP_147074733.1|1837357_1837666_-|HypC/HybG/HupF-family-hydrogenase-formation-chaperone
MCLGIPMQVIEAEESYAVCRGRDGNLARIDTMLVGSVQSGQWLMTFLGGAREILNEQQAEQVNSALNALAAVSRGASDVDVHFADLVGREPQLPDFLRKGGQ
>NZ_AP021884.1|WP_147074734.1|1837670_1838294_-|HyaD/HybD-family-hydrogenase-maturation-endopeptidase
MVEGSQFDTLILGIGNVLWADEGFGVRCVEAMNATYAFPDNVRVMDGGTQGLYLLPYVEAARRLVIFDAVDYGLEPGTLKLVENAEVPKFMGAKKMSLHQTGFQEVLACADLVDHLPEEMVLIGVQPEELEDYGGSLRPRIKARIPEVLEIAVERLVGWGIPVVARGTGETMRTESGILDIQRYEMERPTEEQACRLGDIRFLATGV
>NZ_AP021884.1|WP_147074735.1|1838453_1838801_-|HigA-family-addiction-module-antidote-protein
MVKTFLPSGLGFGAGALDPRFFSFSLRAPIAPGRFLESRFLHPLGLSQDRLARELGISRRRVNELIRGKRAITPDTAIRLGLFFGTGPVLWLTLQQAWDIHQEWRNFRRRSKAHG

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Crispr_ID: NZ_AP021884_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021884_3

2644962-2646084

TypeI

I-C

Consensus_repeat	Method
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	PILER-CR
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	CRISPRCasFinder
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	CRT

15 spacers

cas2,cas1,cas4,cas7,cas8c,cas5

The CRISPR arrays of NZ_AP021884_3

>merge|NZ_AP021884|3|2644962-2646084|PILER-CR,CRISPRCasFinder,CRT
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACATGGTGCGATCCTGTTGTTGCTGGTTGTGCTGCGGGGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACTCCATGGTGGGATTCATGATCCAGTGGGCGATTGCGGGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACGTTTTCTGGTGGCAAGGATTCGGCTGTCATGCTGCGGGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACCGGCCGCTGTGGTCGCGCCCGACATCCTCGCCGCGGGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACAACTGGCGGAGGAGATCGAAATGCAAAAAGCCCGGGGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACATACCGGTAGCGTCGGCAATACCCTGACCGCAGCGGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACACGACGCAGGTTATAGAGCGTTGCACGGCAAAATTGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACGGCCCATGGCAGCTTAAGGTCGGGTATCCCGCTGGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACCTAACCTGCCTTACACAGCCAGCCGCTACGATGAGGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACACCGGTTCATCGCCGTGCCGCCTGTCCATCGCCGCGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACTCGGTCATGGGTGCCAGTTACACTATCCCGATGGACGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACGCATAATGGGACGTTCCGTCAATCTGCGAAGCGCGAGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACAACAATTTCTTGCTGGATAAAATCAAGCCGCTTAGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACAGCATGATCCAAATGGATGCCTTGCGGTAGCTTGGCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAACGCCATGGGTAGCACCGATTAGCACCTTGCCAAAGCGCATCGCCCGGCCTCGCGGCCGGGCGCGGTCAGGTAC

>NZ_AP021884|3|1|2644962-2646012|PILER-CR
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ATGGTGCGATCCTGTTGTTGCTGGTTGTGCTGCGGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	TCCATGGTGGGATTCATGATCCAGTGGGCGATTGCGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GTTTTCTGGTGGCAAGGATTCGGCTGTCATGCTGCGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	CGGCCGCTGTGGTCGCGCCCGACATCCTCGCCGCGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	AACTGGCGGAGGAGATCGAAATGCAAAAAGCCCGGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ATACCGGTAGCGTCGGCAATACCCTGACCGCAGCG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ACGACGCAGGTTATAGAGCGTTGCACGGCAAAATT
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GGCCCATGGCAGCTTAAGGTCGGGTATCCCGCTG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	CTAACCTGCCTTACACAGCCAGCCGCTACGATGAG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ACCGGTTCATCGCCGTGCCGCCTGTCCATCGCCGC
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	TCGGTCATGGGTGCCAGTTACACTATCCCGATGGAC
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GCATAATGGGACGTTCCGTCAATCTGCGAAGCGCGA
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	AACAATTTCTTGCTGGATAAAATCAAGCCGCTTA
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	AGCATGATCCAAATGGATGCCTTGCGGTAGCTTG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC

>NZ_AP021884|3|3|2644962-2646084|CRISPRCasFinder
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ATGGTGCGATCCTGTTGTTGCTGGTTGTGCTGCGGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	TCCATGGTGGGATTCATGATCCAGTGGGCGATTGCGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GTTTTCTGGTGGCAAGGATTCGGCTGTCATGCTGCGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	CGGCCGCTGTGGTCGCGCCCGACATCCTCGCCGCGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	AACTGGCGGAGGAGATCGAAATGCAAAAAGCCCGGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ATACCGGTAGCGTCGGCAATACCCTGACCGCAGCG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ACGACGCAGGTTATAGAGCGTTGCACGGCAAAATT
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GGCCCATGGCAGCTTAAGGTCGGGTATCCCGCTG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	CTAACCTGCCTTACACAGCCAGCCGCTACGATGAG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ACCGGTTCATCGCCGTGCCGCCTGTCCATCGCCGC
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	TCGGTCATGGGTGCCAGTTACACTATCCCGATGGAC
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GCATAATGGGACGTTCCGTCAATCTGCGAAGCGCGA
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	AACAATTTCTTGCTGGATAAAATCAAGCCGCTTA
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	AGCATGATCCAAATGGATGCCTTGCGGTAGCTTG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GCCATGGGTAGCACCGATTAGCACCTTGCCAAAGC
GCATCGCCCGGCCTCGCGGCCGGGCGCGGTCAGGTAC

>NZ_AP021884|3|1|2644962-2646084|CRT
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ATGGTGCGATCCTGTTGTTGCTGGTTGTGCTGCGGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	TCCATGGTGGGATTCATGATCCAGTGGGCGATTGCGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GTTTTCTGGTGGCAAGGATTCGGCTGTCATGCTGCGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	CGGCCGCTGTGGTCGCGCCCGACATCCTCGCCGCGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	AACTGGCGGAGGAGATCGAAATGCAAAAAGCCCGGG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ATACCGGTAGCGTCGGCAATACCCTGACCGCAGCG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ACGACGCAGGTTATAGAGCGTTGCACGGCAAAATT
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GGCCCATGGCAGCTTAAGGTCGGGTATCCCGCTG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	CTAACCTGCCTTACACAGCCAGCCGCTACGATGAG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	ACCGGTTCATCGCCGTGCCGCCTGTCCATCGCCGC
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	TCGGTCATGGGTGCCAGTTACACTATCCCGATGGAC
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GCATAATGGGACGTTCCGTCAATCTGCGAAGCGCGA
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	AACAATTTCTTGCTGGATAAAATCAAGCCGCTTA
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	AGCATGATCCAAATGGATGCCTTGCGGTAGCTTG
GCATCGCCCGGCCTCGCGGCCGGGCGCGGATTGAAAC	GCCATGGGTAGCACCGATTAGCACCTTGCCAAAGC
GCATCGCCCGGCCTCGCGGCCGGGCGCGGTCAGGTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021884.1\|WP_147072282.1\|2643084_2643402_-\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	gnl\|CDD\|223932
NZ_AP021884.1\|WP_147072290.1\|2647849_2649325_-\|metalloprotease-TldD	unknown	unknown	gnl\|CDD\|182685
NZ_AP021884.1\|WP_147072303.1\|2660079_2660286_+\|zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|226826
NZ_AP021884.1\|WP_147072277.1\|2642112_2642739_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NZ_AP021884.1\|WP_147072288.1\|2647299_2647656_-\|DUF2934-domain-containing-protein	unknown	unknown	gnl\|CDD\|378572
NZ_AP021884.1\|WP_124705901.1\|2641666_2641873_+\|2-oxoisovalerate-dehydrogenase	unknown	unknown	unknown
NZ_AP021884.1\|WP_147072305.1\|2660694_2661141_+\|6-carboxytetrahydropterin-synthase-QueD	unknown	unknown	gnl\|CDD\|376501
NZ_AP021884.1\|WP_147072286.1\|2644492_2644783_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_AP021884.1\|WP_147072268.1\|2637986_2638685_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl\|CDD\|187782
NZ_AP021884.1\|WP_147072307.1\|2661191_2661659_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|176643
NZ_AP021884.1\|WP_147072270.1\|2638681_2640466_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|378245
NZ_AP021884.1\|WP_147072292.1\|2649382_2650324_-\|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|143596
NZ_AP021884.1\|WP_147072301.1\|2656415_2659091_+\|bifunctional-[glutamate--ammonia-ligase]-adenylyl-L-tyrosine-phosphorylase/[glutamate--ammonia-ligase]-adenylyltransferase	unknown	unknown	gnl\|CDD\|236836
NZ_AP021884.1\|WP_147072457.1\|2659154_2660069_+\|branched-chain-amino-acid-transaminase	unknown	unknown	gnl\|CDD\|235841
NZ_AP021884.1\|WP_147072295.1\|2650366_2654170_-\|TIGR02099-family-protein	unknown	unknown	gnl\|CDD\|273971
NZ_AP021884.1\|WP_147072275.1\|2641869_2642112_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
NZ_AP021884.1\|WP_147072299.1\|2654382_2656353_-\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NZ_AP021884.1\|WP_147072279.1\|2642722_2643097_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_AP021884.1\|WP_147072272.1\|2640483_2641584_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NZ_AP021884.1\|WP_147072284.1\|2643449_2644484_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360

Protein	Function_ID	Function_description	E-value
NZ_AP021884.1\|WP_147072282.1\|2643084_2643402_-\|ribbon-helix-helix-protein,-CopG-family	gnl\|CDD\|223932	COG0864, NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription].	0.000512093
NZ_AP021884.1\|WP_147072290.1\|2647849_2649325_-\|metalloprotease-TldD	gnl\|CDD\|182685	PRK10735, tldD, protease TldD; Provisional.	0
NZ_AP021884.1\|WP_147072303.1\|2660079_2660286_+\|zinc-finger-domain-containing-protein	gnl\|CDD\|226826	COG4391, COG4391, Uncharacterized protein conserved in bacteria [Function unknown].	7.87518e-13
NZ_AP021884.1\|WP_147072277.1\|2642112_2642739_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	3.28503e-34
NZ_AP021884.1\|WP_147072288.1\|2647299_2647656_-\|DUF2934-domain-containing-protein	gnl\|CDD\|378572	pfam11154, DUF2934, Protein of unknown function (DUF2934). This bacterial family of proteins has no known function.	2.46043e-11
NZ_AP021884.1\|WP_147072305.1\|2660694_2661141_+\|6-carboxytetrahydropterin-synthase-QueD	gnl\|CDD\|376501	pfam01242, PTPS, 6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.	1.0766e-35
NZ_AP021884.1\|WP_147072286.1\|2644492_2644783_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	4.80989e-26
NZ_AP021884.1\|WP_147072268.1\|2637986_2638685_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187782	cd09651, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	4.50083e-97
NZ_AP021884.1\|WP_147072307.1\|2661191_2661659_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	1.56238e-59
NZ_AP021884.1\|WP_147072270.1\|2638681_2640466_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NZ_AP021884.1\|WP_147072292.1\|2649382_2650324_-\|carbon-nitrogen-hydrolase-family-protein	gnl\|CDD\|143596	cd07572, nit, Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases). This subgroup includes mammalian Nit1 and Nit2, the Nit1-like domain of the invertebrate NitFhit, and various uncharacterized bacterial and archaeal Nit-like proteins. Nit1 and Nit2 are candidate tumor suppressor proteins. In NitFhit, the Nit1-like domain is encoded as a fusion protein with the non-homologous tumor suppressor, fragile histidine triad (Fhit). Mammalian Nit1 and Fhit may affect distinct signal pathways, and both may participate in DNA damage-induced apoptosis. Nit1 is a negative regulator in T cells. Overexpression of Nit2 in HeLa cells leads to a suppression of cell growth through cell cycle arrest in G2. These Nit proteins and the Nit1-like domain of NitFhit belong to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 10.	2.62549e-145
NZ_AP021884.1\|WP_147072301.1\|2656415_2659091_+\|bifunctional-[glutamate--ammonia-ligase]-adenylyl-L-tyrosine-phosphorylase/[glutamate--ammonia-ligase]-adenylyltransferase	gnl\|CDD\|236836	PRK11072, PRK11072, bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase.	0
NZ_AP021884.1\|WP_147072457.1\|2659154_2660069_+\|branched-chain-amino-acid-transaminase	gnl\|CDD\|235841	PRK06606, PRK06606, branched-chain amino acid transaminase.	0
NZ_AP021884.1\|WP_147072295.1\|2650366_2654170_-\|TIGR02099-family-protein	gnl\|CDD\|273971	TIGR02099, probable_transmembrane_protein, TIGR02099 family protein. This model describes a family of long proteins, over 1250 amino acids in length and present in the Proteobacteria. The degree of sequence similarity is low between sequences from different genera. Apparent membrane-spanning regions at the N-terminus and C-terminus suggest the protein is inserted into (or exported through) the membrane. [Hypothetical proteins, Conserved].	0
NZ_AP021884.1\|WP_147072275.1\|2641869_2642112_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	5.16073e-09
NZ_AP021884.1\|WP_147072299.1\|2654382_2656353_-\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NZ_AP021884.1\|WP_147072279.1\|2642722_2643097_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	1.70684e-21
NZ_AP021884.1\|WP_147072272.1\|2640483_2641584_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	2.00115e-94
NZ_AP021884.1\|WP_147072284.1\|2643449_2644484_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	2.95812e-179

>NZ_AP021884.1|WP_147072286.1|2644492_2644783_+|CRISPR-associated-endonuclease-Cas2
MLIIVTYDVSTETAAGRKRLRRVAKACEKMGQRVQKSVFECTVNEMQFEQLERTLLAEIDETQDNLRFYRITEPVEVRVKQHGCFRSVDFEGPLIA
>NZ_AP021884.1|WP_147072284.1|2643449_2644484_+|type-I-C-CRISPR-associated-endonuclease-Cas1
MHTIQNTLYVMTPHAYAHLENATLRIDVEREKKLQVPLHHLGGVVCFGNVMVSPALMHRLADEGKSLVLLDDSGRFKARLEGPVSGNILLRQAHHSKASEPAFALGVARAVVAGKLKNSRTNLQRGAREAADPDEAATLTRSADNLAASLRAAAVANTMDELRGVEGEAARGYFAALNLIVKPLARPSFALNGRSRRPPLDRFNALLSFLYAMLMNDCRSAVEAAGLDAQLGFLHAVRPGRAALALDLQEEFRSILADRLALTLINRGQINAADFDEREGGAVMLGDKGRRTVVTAWQERKQEEITHPLTENKIPIGLLPFIQARFIARTIRGEMEGYLPYQAK
>NZ_AP021884.1|WP_147072282.1|2643084_2643402_-|ribbon-helix-helix-protein,-CopG-family
MATLTLRLPDNLDRQLTALAAQTHQNRSELARTALEKFLRELEQEQLLAEMVEAARFLATNPEARAESIAIAEEFLPLDNEALDIAEGRKPGDPWPEELGEKWWK
>NZ_AP021884.1|WP_147072279.1|2642722_2643097_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MVEIMRRGEIWLARLNPNTGAEAGKVRPVLILLNDALLATGMSPVLCIPLTSKLYKNLAGLRIAIAPRGLLLKPCYAMPEQARALDRNRFGEGSLATLTNAEMAQVEKLFIAACGMAQYLIPQH
>NZ_AP021884.1|WP_147072277.1|2642112_2642739_+|CRISPR-associated-protein-Cas4
MANSADEIVALSALQHWIYCPRQCGLIHLEQAFEDNVHTARGQAVHHLVDTPGYEIKSGVRVERALPVWCDRLNLIGKADLVEFHPDDSVYPVEFKHGAKRQKLHDDIQLAAQAICLEEMLNRPVPKGAIFHATSHRRREVSITPELKQLVEETANAIRAMLASGKLPPPVNDARCRECSLKEICQPEALAERGRLERLREELFSAAG
>NZ_AP021884.1|WP_147072275.1|2641869_2642112_+|type-II-toxin-antitoxin-system-HicA-family-toxin
MRVPRDLSGADLVKRLERMGYCVTRQTGSHMRLTSTVRGEHHITIPNHDPLRLGTLASILASVAAHHGLTRDELIQRLFD
>NZ_AP021884.1|WP_124705901.1|2641666_2641873_+|2-oxoisovalerate-dehydrogenase
MSEIHFIVEEAPEGGYVARAVGVDIVTEADDLPSLHAQVRDAVHCHFDEGKLPGLIRLHITREEVLTA
>NZ_AP021884.1|WP_147072272.1|2640483_2641584_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSIHNRYDFVLLFDVKDGNPNGDPDAGNLPRLDTETGQGLITDVSIKRKIRNFVGITKCKEDGTYETGFDIYIKEKAVLGRAHFAAFEKLGISLGQDATELIPDDLAEQFEALTLPEGMEIDTDEEGRSILNLSGATLDKKEAQKWLKDINPAKPLKNFISKVLKNVTARKPKQEESEKGRVQMCQDFYDIRTFGAVLSLKTAPNCGQVRGPVQITFARSIDPIVTLEHSITRCAVATEAEAEKQGGDNRTMGRKFTVPYGLYRTHGFVSAHLAGQTKFDESDLELLWEALKNMFEHDHSAARGEMATRGLYVFKHESHLGNEAAHKLFDRIKVNKTKDVPRGFEDYEVSVDETEMPSGVALLQKC
>NZ_AP021884.1|WP_147072270.1|2638681_2640466_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MILQSLHEYYGRKRDSLPGDGIERKELPFLFVLKPDGAFLHIEDTRQGEGKRKRGNAFLVPQGVKKSVNVAANLLWGNVEYVIGQPDSKKLEEQRKKGKEKHYRERLGDMCSAFRTEIEQLPSEVKSTPEVAAVLAFLSSGNFTHVLADPLWPQVSATGANVSFKLTGAESPVCSASGILASVGQSTEDKGETRICLITGNSDVVERLHPPIKGVWGAQTSGANIVSFNLSAFNSFAREQGSNAPVGKRAAFAYTTALNHLLVSKQRIQIGDASTVFWAAEDNKMESLLSQFFDEPPQDNPDQGTNAVKELLEATLAGTPAIYDDGTRFYVLGLAPNAARIAVRFWHVATVGDLAGHIRQHFEDLEIVRPQYVERPFLSLKALLLAVSPLGDLDKLPPKLAGDFMKAILDGTSYPQTLLQAALRRIHAEQAKKDEKTGKHRDHVPYARAALIKAWLNRQTRNANPDQERKITMSLDESNINSGYRLGRLFAVLEKVQAEANPGLNTTIRDSYFGSASSTPSAVFPTLMRRNQHHMTKLRKEKPGLYVTRDKLIQTICNDGIDGQLGFRPILSLADQGRFVIGYYQQRQDLFTKS
>NZ_AP021884.1|WP_147072268.1|2637986_2638685_+|type-I-C-CRISPR-associated-protein-Cas5
MPKTLCLKVWGDFACFTRPEMKVERVSYDVITPSAARAVFEAILWKPEIRWTVTKIEVLKPIKWISVRRNEIGKVASADNGQGDRGLYIEEHRQQRAGLFLRDVAYRLHAQFEVVDGSKHVHHYPELRGRFPAEPEESQPEHPAKYLSMFQRRAKKGQCFWQPYLGCREFSAHFELVDDAAAASLAEPPISDSPSLGWMLHDIDFADAMRPGFFRAEMKSGIIDLEDVEVRR
>NZ_AP021884.1|WP_147072288.1|2647299_2647656_-|DUF2934-domain-containing-protein
MAESKAKSKASGKPVSAVAETKPKAKTAQPAAGKAAAQSAVAAKPKVAKPKVAAPGANEPAAKRSVKLSNPAVSAEQRYRMIAEAAYYIAERRNFAPGDAAADWAQAEVQIVALLNKK
>NZ_AP021884.1|WP_147072290.1|2647849_2649325_-|metalloprotease-TldD
MTTSTLTGVLIPNPEMLFQTAHETLLVPNQLEASQLDGVFGRLMDHHVDYADLYFQYTRSEGWSLEEGQVKSGSFNIEQGVGVRAVSGEKTAFAYSDDISQPALLAAAEATRAIARSGAVRKPHAVARGGGHALYQPLDPLTTLKDAEKVALLEKLERYARAIDSRVTQVMASLASEYDVVLIARSDGHQAADVRPLVRLSLQVITEQDGRREQGSAGGGGRFGYDYFSDAMLKKYAEQAVHQALTNLAARPAPAGSMTVVLGAGWPGILLHEAIGHGLEGDFNRKGSSAFAGRVGERVAATGVTVVDDGTLMNRRGSLNVDDEGNLTQCTTLIENGVLKGYMQDTLNARLMGVPITGNARRESFAHIPMPRMTNTYMLNGDKDPEEIIASVKHGLYAVNFGGGQVDITSGKFVFSAAEAYMIEDGKITYPVKGATLIGNGPDVLTRVSMIGNDMALDPGVGTCGKEGQSVPVGVGQPTLRIDGLTVGGTA
>NZ_AP021884.1|WP_147072292.1|2649382_2650324_-|carbon-nitrogen-hydrolase-family-protein
MEKIVSDKTSKSPSSFAKPKSRTTVAKPARAPAPGVIRMAAIQMASGPNVSANLAEAERLVALAVAGGAKLVVLPEFFAIMGNKDTDKVAAREEEGKGPIQKFLASAAKKHKIWLVGGSVPLACDNPKKVRNSCLVYDDKGKLVARYDKIHLFGLDLGVEHYQEEKTIEPGDQIVVLDSPFGRIGLSVCYDLRFPELYRAMPNVDIILVPSAFTATTGKAHFETLVRARAIENLAYVIAPAQGGYHLSGRETHGDTMIVDPWGVVLDRLPRGSGVVMAGINPAYQASLRKSLPALKHRTLDCSHIQIKDKAIK
>NZ_AP021884.1|WP_147072295.1|2650366_2654170_-|TIGR02099-family-protein
MIAFSRRWIRRSVDYVVLPLALVVVVLVLLLRLWILPDIDRWRDDIAASISHSAGQRVTLGEINANWQGLHPHLRIRDIRVFGADGRPVLFLADVRATLSWTSLLHGELRLAVLTMDDVALTIRRDMQGIHVAGILLNQSDSSGGFGDWLLAQRHIQVNHATLAWNDERRGAPYLVARDVNLTLQNRGHRHRFRLTAIPPEQLAQPLDIRGDFSGRSLDDLASWHGQVYARVDRTDLGQWRQWLTLPYAISQGYGGLRMWLDVASRQVIAATVDASLRQVSVRFAADLPVLRLADVSGRGLWKRLGPAQSFAVKQLSLRTANFVYVAPFDLTLRLDPANAIQPGSGRIDTNSVQLDRLAALAPYLPLDAVQRRRLADLQPRGQLEKFTLAWSGNADQPLDYQIKGRFTRLGWQAQGNLPGAAGLSGNIDATRSNGTLALTSSGVMLALPRVLFEPDVALTTLTARMNWRATQAGYLIKLTEASFANPDLAGSAFGEYQLQAGRRGVIDLTGRLSRANVASAYHYLPLVVKDPTYQWVRSALLAGQGGAASIRLQGDLSRFPFRKAGDGVFEISTPISNGVLQYAAGWPRIEGIQAQLKFTGTRMEISSDAATIYGAALRRVSAVIPDLVDPDEILEVKGEAAGPLAELVRFANTSPLAAKLDNVTDNLRTTGNSRLGLDLKLPLRRAHHATLVGDIRFLGNTLIPAHGLPTLENVQGRLSFTDTGISAQSISARLLGGAATLSAVTQPGGVTRLLVDGRMTAAGLRPYLGTALAGHLSGMADWHARVDLHQMQAQADFESNLVGMASDLPPPFAKAAADSQPLRVKKSLRGADESLLAIHYGQVASALLLQKQKDGEPVIERGTLRFGGEAVLPEESGLWITGSLLLSDLDLWRNELTAAGNGAIGLPPLAGVNLSFRTLDLFGRRFQDININARNQAGTWRANVAGRGVNGDVTWQAADSRAGQPQDRLGAHFKTLAIPAALPVQGVKSSPSGSLPALDISVDNLQLGNRPLGRLSVSATPLDSGLNFESIRLTQPDSTLTMQGIWNPDRIPQTRAKIHLEVNDVGRFLARFDHPGLVKRGQATLDGEGEWNGTPADIAIPSLSGTFALKASSGQFAKVDPGIGKLLGVLSLQALPRRIGLDFRDVFSDGFAFDEISGTMRLSRGVVYSDDFRMQGPSAKVRMSGMVDINAETQQLRVAVSPKLSESVALAGTLIGGPFVGLGALAVQKLLKDPFGQAATFEYSVTGAWTDPVVKRVARIAGGGEP
>NZ_AP021884.1|WP_147072299.1|2654382_2656353_-|acetate--CoA-ligase
MANIESVLQETRVFPPSAAFQAQANVSGMASHQALTARAAADYEGFWADMARAGISWKKDFSKILDESNAPFYKWFYDGELNVSYNCLDRHLPEKADKTALIFEADDGAVRRVTYQALYNQVCAFANGLKSRGVQKGDRVIIYMPMGVEAVVAMQACARIGAIHSVVFGGFSAKSLHERIRDAGARLVVTADGSIRGGKMLPLKSAVDAAIALGDCECVEAVVVYRRSGDDTAWNAARDIWWHDLVNGMAQTCEPEWVNAEHPLFILYTSGSTGHPKGVQHSSGGYLLGAILSMQWVFDARPDTDVFWCTADVGWITGHSYVVYGPLALGMTEVIFEGVPTYPDAGRFWKMIQDHQVTTFYTAPTAIRSLIKLGSDLPRQYDLSSLRLLGTVGEPINPEAWMWYYEAVGQSRCPIADTWWQTETGSHMIAPLPGAVATKPGSCTLPLPGIMADVVDEHGGSVPLGQGGYLVIKRPFPSLLRSLWGDPERFRKTYFPAELGGKTYLAGDSAHRDADGYYWIMGRIDDVLNVSGHRLGTMEIESALAANPRVAEAAVVGKPHDIKGEAVVAFVVLKGARASGDEAKKIVAELRDWVGKEIGPIAKPDEIRFGDNLPKTRSGKIMRRLLRAIARGEEITQDVSTLENPAILEQLKEAVR
>NZ_AP021884.1|WP_147072301.1|2656415_2659091_+|bifunctional-[glutamate--ammonia-ligase]-adenylyl-L-tyrosine-phosphorylase/[glutamate--ammonia-ligase]-adenylyltransferase
MPAHHLIERAASHSRYLARLLAADAQFVDSLASGLAQPFGADAMQAQLQAAAPGDEAMLKTALRKLRQAVMARLIVRDLGGLADLSEVMGTCTDLAETTLRCALAHHSTWLAQKHGMPKNPDGSDMQLVVVGMGKLGGRELNVSSDIDLIYLYPEQGETTGAKPVSHHEFFVLLGKKLGLAISDLTADGFVFRVDMRLRPWGDAGPLAMSYAALEDYLVAHGREWERYAWIKGRALTGTRLAELDQIIRPFVFRKYLDFNAFAAMRELHVQIRREVIRRDRADNIKLGPGGIREIEFTAQVFQLIRGGQVAVLQTRSLLAVLPLLAARGLLPENAVAELQAAYVFLRNLEHRLQYLDDAQTQMLPTQPDDRTRIATSMGFTDYPAFLAALNAHRTQVSRHFDQVFAAPQADSGSHPLAGLWQGALEHADALATLAGLGYTAPAEVCNRLRQIRTSIRYTTLPASNRARFDTLMPALIEVAASCNPPDATLARILDLLETVARRDSYLALLVEYPATLQRVARLCAASPWAAQYLARNPMLLDELLDTRQLYATPDWPALGDELQALMHTHCGDTERQMDAMRQFRQRVTFHLLAQDLAGVLALETLSDHLSDLAALILSATLPLAWAGVRNRHRDTPRFAVIGYGKLGGREMGYASDLDLVFLYEDPAPAAAEHYARLAQRINTWLGSTTAAGVLYETDLRLRPDGTSGLLVSSVEAFSQYQHSHAWTWEHQALTRARYVAGDAAVGAAFERIRCDILTQPRDPARLREDVLAMRQKMHAGHPNHSDLFDLKHDAGGIVDVEFMVQYLVLAHAARHRELTRNSGNIALLRLAAELELIPASDAEAVRSAYRELRRLQHALRLHGIQTARIEPMQVAGHAAAVRRLWRTLFG
>NZ_AP021884.1|WP_147072457.1|2659154_2660069_+|branched-chain-amino-acid-transaminase
MADRDGFIWYDGKMVPWRDATTHVLTHTLHYGMGVFEGVRAYNTDQGTAIFRLQEHTDRLFRSAHILGMKMPFDKAAISAAQLAAVRDNQLESAYIRPMAFYGAEAMGISAKTLSTHVIVAAWTWGAYMGAEALERGIRVKTSSFARHHVNIAMCKAKANGNYMNSILAHQEAAQDGYQEALLLDVDGFVAEGSGENVFIVRNGKLITPDLTSALEGITRDTIVQLAGEIGLQVVEKRITRDEMYSADEAFFTGTAAEVTPIRELDNRTIGTGARGPITAQLQKMYFDCVTGKDPKHAGWLSYI
>NZ_AP021884.1|WP_147072303.1|2660079_2660286_+|zinc-finger-domain-containing-protein
MAQVQHENTQRIIEVTADDLPLHCPTPGMIAWDSHPRVFLPVEVKGEALCPYCGTMYILKGGAVAHGH
>NZ_AP021884.1|WP_147072305.1|2660694_2661141_+|6-carboxytetrahydropterin-synthase-QueD
MLITRRLEFDAGHRIPNHASQCKHLHGHRYAIEITLSGDIITAEGQSEQGMVMDFSDVKRIAREQLVDAWDHAFLAYRGDKPVCDFLATLTDHKTIILELVPTVENLAHIAFDILDPAYRDTYGNQLRLKQVRIYETPNNWADCRQPE
>NZ_AP021884.1|WP_147072307.1|2661191_2661659_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MGMTMTSTAFAHHGAIPEHYTCDATDTSPPLAWAGVPVGAKSLVLIVDDPDAPDPAAPQRTWVHWLLYNLPPTSSGLAEGVTALPAGTLEGINDWKRTGYGGPCPPIGRHRYFHKLYALDVVLPNLDRPSKAALEKAMQGHILAQTELIGLYQRH

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Crispr_ID: NZ_AP021884_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP021884_4

2907296-2907401

Orphan

Consensus_repeat	Method
GATTCCAACGACTGGGTGCGGCTGGGCAGTATGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP021884_4

>merge|NZ_AP021884|4|2907296-2907401|CRISPRCasFinder
GATTCCAACGACTGGGTGCGGCTGGGCAGTATGGCAGCCACCTTTGGAAAATATCCTGTCTGGTCATGCTGCGATTCCAACGACTGGGTGCGGCTGGGCAATATGG

>NZ_AP021884|4|4|2907296-2907401|CRISPRCasFinder
GATTCCAACGACTGGGTGCGGCTGGGCAGTATGG	CAGCCACCTTTGGAAAATATCCTGTCTGGTCATGCTGC
GATTCCAACGACTGGGTGCGGCTGGGCAATATGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP021884.1\|WP_147070049.1\|2893538_2894183_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_AP021884.1\|WP_147070045.1\|2896848_2897325_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NZ_AP021884.1\|WP_147070013.1\|2919448_2920984_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021884.1\|WP_147070015.1\|2918246_2919452_+\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224376
NZ_AP021884.1\|WP_147070033.1\|2903228_2905838_+\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NZ_AP021884.1\|WP_147070035.1\|2900312_2901191_+\|sulfur-oxidation-c-type-cytochrome-SoxA	unknown	unknown	gnl\|CDD\|275277
NZ_AP021884.1\|WP_147070043.1\|2897364_2898786_+\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|227122
NZ_AP021884.1\|WP_147070027.1\|2908463_2909963_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021884.1\|WP_147070039.1\|2899397_2899865_+\|thiosulfate-oxidation-carrier-protein-SoxY	unknown	unknown	gnl\|CDD\|275281
NZ_AP021884.1\|WP_147070022.1\|2910437_2912018_+\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_AP021884.1\|WP_147070029.1\|2907798_2908467_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|334855
NZ_AP021884.1\|WP_147070018.1\|2915348_2916524_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_AP021884.1\|WP_147070041.1\|2898997_2899366_+\|sulfur-oxidation-c-type-cytochrome-SoxX	unknown	unknown	gnl\|CDD\|275278
NZ_AP021884.1\|WP_147070037.1\|2899922_2900237_+\|thiosulfate-oxidation-carrier-complex-protein-SoxZ	unknown	unknown	gnl\|CDD\|275283
NZ_AP021884.1\|WP_147070024.1\|2909981_2910410_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP021884.1\|WP_147070047.1\|2894604_2896824_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|182070
NZ_AP021884.1\|WP_147070267.1\|2901373_2903095_+\|thiosulfohydrolase-SoxB	unknown	unknown	gnl\|CDD\|275279
NZ_AP021884.1\|WP_147070265.1\|2913576_2915352_+\|secretin-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|274176
NZ_AP021884.1\|WP_147070016.1\|2916529_2918233_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	unknown	unknown	gnl\|CDD\|225363
NZ_AP021884.1\|WP_147070020.1\|2912147_2913497_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|132060

Protein	Function_ID	Function_description	E-value
NZ_AP021884.1\|WP_147070049.1\|2893538_2894183_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.21355e-19
NZ_AP021884.1\|WP_147070045.1\|2896848_2897325_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	7.41376e-93
NZ_AP021884.1\|WP_147070015.1\|2918246_2919452_+\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224376	COG1459, PulF, Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion].	4.4338e-95
NZ_AP021884.1\|WP_147070033.1\|2903228_2905838_+\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NZ_AP021884.1\|WP_147070035.1\|2900312_2901191_+\|sulfur-oxidation-c-type-cytochrome-SoxA	gnl\|CDD\|275277	TIGR04484, sulfur_oxidation_protein_SoxA, sulfur oxidation c-type cytochrome SoxA. Members of this family are SoxA, a c-type cytochrome with a CxxCH motif, part of a heterodimer with SoxX. SoxXA, SoxYZ, and SoxB contribute to thiosulfate oxidation to sulfate.	6.73613e-89
NZ_AP021884.1\|WP_147070043.1\|2897364_2898786_+\|M48-family-metalloprotease	gnl\|CDD\|227122	COG4783, COG4783, Putative Zn-dependent protease, contains TPR repeats [General function prediction only].	8.23851e-106
NZ_AP021884.1\|WP_147070265.1\|2913576_2915352_+\|secretin-N-terminal-domain-containing-protein	gnl\|CDD\|274176	TIGR02519, related_to_type_II_protein_secretion_protein, pilus (MSHA type) biogenesis protein MshL. Members of this family are predicted secretins, that is, outer membrane pore proteins associated with delivery of proteins from periplasm to the outside of the cell. Related families include GspD of type II secretion (TIGR02517), the YscC/HrcC family from type III secretion (TIGR02516), and the PilQ secretin of type IV pilus formation (TIGR02515). Members of this family are found in gene clusters associated with MSHA (mannose-sensitive hemagglutinin) and related pili, and appear to be the secretin of this pilus system. [Cell envelope, Surface structures].	1.6517e-68
NZ_AP021884.1\|WP_147070039.1\|2899397_2899865_+\|thiosulfate-oxidation-carrier-protein-SoxY	gnl\|CDD\|275281	TIGR04488, sulfur_oxidation_protein_SoxY, thiosulfate oxidation carrier protein SoxY. Members of this family are bona fide SoxY, the sulfate carrier protein with the GGCGG ir GGCG swinging arm C-terminal sequence. The Cys in the swinging arm is the residue to which the inorganic sulfate moiety becomes covalently attached. In some species, a closely related paralog occurs as well (TIGR04487), with a swinging arm sequence AACIE. More distantly related forms have an additional C-terminal SoxZ-related domain. All members are periplasmic and have an N-terminal twin-arginine translocation (TAT) signal sequence.	1.48644e-53
NZ_AP021884.1\|WP_147070022.1\|2910437_2912018_+\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	2.704e-133
NZ_AP021884.1\|WP_147070029.1\|2907798_2908467_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|334855	pfam02230, Abhydrolase_2, Phospholipase/Carboxylesterase. This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.	6.00127e-56
NZ_AP021884.1\|WP_147070018.1\|2915348_2916524_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	4.40249e-09
NZ_AP021884.1\|WP_147070041.1\|2898997_2899366_+\|sulfur-oxidation-c-type-cytochrome-SoxX	gnl\|CDD\|275278	TIGR04485, monoheme_cytochrome_c_SoxX, sulfur oxidation c-type cytochrome SoxX. Members of this family are SoxX, a c-type cytochrome with a CxxCH motif, part of a heterodimer with SoxA. SoxXA, SoxYZ, and SoxB contribute to thiosulfate oxidation to sulfate.	2.85067e-39
NZ_AP021884.1\|WP_147070037.1\|2899922_2900237_+\|thiosulfate-oxidation-carrier-complex-protein-SoxZ	gnl\|CDD\|275283	TIGR04490, sulfur_oxidation_protein_SoxZ, thiosulfate oxidation carrier complex protein SoxZ. SoxZ forms a heterodimer with SoxY, the subunit that forms a covalent bond with a sulfur moiety during thiosulfate oxidation to sulfate. Note that virtually all proteins that have a SoxY domain fused to a SoxZ domain are functionally distinct and not involved in thiosulfate oxidation.	4.58831e-48
NZ_AP021884.1\|WP_147070047.1\|2894604_2896824_+\|EAL-domain-containing-protein	gnl\|CDD\|182070	PRK09776, PRK09776, putative diguanylate cyclase; Provisional.	0
NZ_AP021884.1\|WP_147070267.1\|2901373_2903095_+\|thiosulfohydrolase-SoxB	gnl\|CDD\|275279	TIGR04486, Sulfur_oxidation_protein_SoxB, thiosulfohydrolase SoxB. SoxB, a di-manganese(II) enzyme, works with SoxYZ and the c-type cytochrome SoxXA in oxidation of thiosulfate to sulfate.	0
NZ_AP021884.1\|WP_147070016.1\|2916529_2918233_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	gnl\|CDD\|225363	COG2804, PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion].	2.76456e-170
NZ_AP021884.1\|WP_147070020.1\|2912147_2913497_+\|AAA-family-ATPase	gnl\|CDD\|132060	TIGR03015, pepcterm_ATPase, putative secretion ATPase, PEP-CTERM locus subfamily. Members of this protein are marked as probable ATPases by the nucleotide binding P-loop motif GXXGXGKTT, a motif DEAQ similar to the DEAD/H box of helicases, and extensive homology to ATPases of MSHA-type pilus systems and to GspA proteins associated with type II protein secretion systems. [Protein fate, Protein and peptide secretion and trafficking].	1.75282e-68

>NZ_AP021884.1|WP_147070033.1|2903228_2905838_+|alanine--tRNA-ligase
MKSSEIRQRFLDFFARHGHTPVASSPLVPGNDPTLLFTNAGMVQFKDVFLGRETRPYARAVSSQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRNAIQFAWEFLTQELGIAKDKLWITVYHTDDEAHTIWTAEMGVPDERVIRIGDKPGGGSDNFWQMGDTGPCGPCTEIFYDHGAEVAGGPPGSADEDGDRYIEIWNLVFMQFNRDEAGNLQPLPRPSVDTGMGLERISAVMQHVHSNYEIDLFQALIHAAARVTGSADLTDNSLKVIADHIRACAFLITDGIIPGNEGRGYVLRRIIRRAIRHGYQLGQKQPFFHLLVADLAMAMGAAYPELVAAQARVTAVLKQEEERFAETLEHGMDILEQALQSGANVLDGATAFKLYDTYGFPLDLTADVGRERGFTVDMAGFEAAMEAQRKRARAASKFTMQAGMRFDGPPTEFRGYDTLSLDSRILALYQDGSPVHSIAAGEAAVIVLDRTPFYAESGGQVGDSGELHGSGSVFVVDDTQKIQPDVFGHTGLLQSGSLKLGDTVSAQVDADARSRAACNHSATHLLHAALRQVLGTHVTQKGSLVDAARTRFDFAHSEAVSAAQLQQIEDLVNREIRRNVIVEARLMNYDAAIAHGAMALFGEKYGDQVRVIGMGEFSTELCGGTHVSRSGDIGLFKIISESGVAAGIRRIEAVTGPAALAMIQAQQRQILEAAALLKAPPQELQQKIAQIVDNVKNLEKELDRLKSRLAAAQGDDLVSQATAVGNAKVLAAMLEGADVKTLRETVDKLKDRLKSCAVVLGSCSDGRVTLVAGVSADLTSKVKAGELANFVASQVGGKGGGRPDMAQAGGTEPAQLPAALQSVAGWVAQRLE
>NZ_AP021884.1|WP_147070267.1|2901373_2903095_+|thiosulfohydrolase-SoxB
MNRREFLQILAVAAASGMAIDNKQALAGNAPSGFYDLPKFGNVSLLHMTDCHAQLLPIYFREPDVNIGVGAAIGQPPHLVGEYLLKYYGIRPGTREAYAFTYLDFAAAARTYGKVGGFAYLKTLVDKVRASRPGSLLLDGGDTWQGSATSLWTNGQDMVDAAKLLGVNVMTGHWEFTYGAERVKHVVDNDFKGHIDFVAQNIKTNDFGDPVFKPYVIKTMNGVQVAIIGQAFPYTPIANPRYMVPDWSFGINDDNMQKVVNEARAKGAQVVVVLSHNGMDVDLKMATRVTGIDAIFGGHTHDGVPQPTQVKNAKGTTLVTNAGSNGKFLGVMDFDVKNGKIAAWKYRLLPVFSNLLEPDAKMAKLIEDVRAPYASKLNEKLAVTEELLYRRGNFNGTFDQLILDALMAVKGADAAFSPGFRWGTTLLSGDVITMDHLMDQTAITYPSTTLTEMTGATIKSIMEDVCDNLFNADPYYQQGGDMVRVGGIQYAVAPNNKIGNRISNMTLKGKPVMASKKYKVAGWAPVGEGVSGTPIWDVVAEYLRDIKVVKPRKLNEPKIVGIGKNPGIAPGIA
>NZ_AP021884.1|WP_147070035.1|2900312_2901191_+|sulfur-oxidation-c-type-cytochrome-SoxA
MKTTFREPQAQSPKAHGKKILLALAGAGLLLGALNASATPEQDRQSLLKFYSSKYPDIKVANYIYGALAFDPDAMEQYNSIMDFPPFGSVIEHGKKMWETPFKNGKKYADCFPNGGKNVAGNYPYFDDKAGKVVTFEMAINACRTANGEEAFKYNDMQTMGTLTAYARTLSDGMPMNIKVQGAAATAAYEAGKSQFYSRRGQLNFSCASCHVANAGNHLRSELLSPAVGQATHWPVFRGGEQLVTLQERYVGCNKQVRAVPFAPGSEEYNNLEYFHSYISNGLPLKASVFRK
>NZ_AP021884.1|WP_147070037.1|2899922_2900237_+|thiosulfate-oxidation-carrier-complex-protein-SoxZ
MAEPMKMRASVSGDVADIKVLMNHPMETGLRKDAKTGQLIPAHFINEVHATVNGKPVLDAQWGGGVSKNPYLGFKVKGAKAGDKVEVSWKDNKGESNKVDGVVA
>NZ_AP021884.1|WP_147070039.1|2899397_2899865_+|thiosulfate-oxidation-carrier-protein-SoxY
MNALRRNILKSAGATGIVAMAAAAGLLKSGNVLAAWNSSAFAAKTVPEAIKDLGLSTPADSKAISIKAPDIAENGAVVPVEVTSSIAGTTGIAIFAEKNATPLITDFKLSNGAEGFISTRIKMGQTAMVRAVVTAGGKTYTAAKEVKVTIGGCGG
>NZ_AP021884.1|WP_147070041.1|2898997_2899366_+|sulfur-oxidation-c-type-cytochrome-SoxX
MRAGASLILTASMVGMFVMANYAVAADTPKQEETGKSIAFDKTKGNCLACHAMPTVPDAVAAGTIGPPLIAMSARYPDKAKLRAQIWDATVANPQSVMIPFGKHKVLTEQEIDKVTDFVYGL
>NZ_AP021884.1|WP_147070043.1|2897364_2898786_+|M48-family-metalloprotease
MKSASLFLALCLASQQLAASELPDLGDVSQGAFSPRDEARVGNEIMRDIYAEPAYYDDPELTDYLNNLGYRLVAASPENRLAFQFFVLRDHTLNAFALPGGFIGVHTGLIEATQSESELAGVLGHEIAHVTQHHLARMIESRNQGILPSLAALAVAILAARSNPQAASAAIATVQATSIQKQLNFSRANEREADRIGMQIMRGAGFDPRAMATFFERLQKNSRLYENNAPAYLLTHPLTSERIADMQNRAASMPVKQVADSLEFQLLRAKLLAGEGRPEEAVRRFTEAIRDTRYNSLAAERYGLVVALLRTRQFDRAEQELDRLNQSGASSPMIAMLGARLRQEAGDLNTALARYQAGRARFPGYRPLLYADANALLQAGKADAALALVTDHLALYPDDYRLYQLQSRAYAMQGKDFLRHHAQAEAYVRQGNLDAAIEQLKLGLKSRDGDFYQMSIAEARLKELVALNQPAKP
>NZ_AP021884.1|WP_147070045.1|2896848_2897325_-|cyclic-pyranopterin-monophosphate-synthase-MoaC
MNQLTHFDDRGRAQMVDVADKSDTRRVAVAAGRIVMQPATLKMILDGSARKGDVLGVARIAAIAASKRTADLIPLCHPLALTRVAVEFLAEEADSAIECRVTAETVGKTGVEMEALTALSVGLLTIYDMCKAVDRGMRMEGLRLLEKQGGKSGHWRAP
>NZ_AP021884.1|WP_147070047.1|2894604_2896824_+|EAL-domain-containing-protein
MTQIDTRLISTATWLAGALAGLIALAFPLVYFSLSYEHQAASMETEAEFEAARIARLINANPELWPFEQSRLQELLQDQTETELPESRRIVDVNGRLIAQSQGKSARPYLLRTADLRNSGSVAGRVEIIRSLRPLLLKTAMASLLGLLLGSLAMVIFRAYPLRILKRALNTLANEKERAEVTLHSIGDAVITTNASGHIEYLNPVAEQLTGWTNEAARGLPSWRVFNIINESTGAPLDSPAEKAIKENRIVPLANHAGLVKRNGKIIPIENSAAPICDSQGQIIGAVLVFHDVSHARAMATKLSHQASHDPLTGLINRHTFESRLQQALDNVRRENSHHTLCYMDLDQFKIVNDTCGHRAGDELLRQLAGELRTKVRNSDCLARLGGDEFGLLLEGCTVQQAEHVAATLLQTVKEFRFHWQEHTCAVGVSIGLVGINAGCGDLAKIMGAADSSCYAAKDRGRNCIYVYQPDDKEVAQRRGEMQWVARITRAIDEGRLRLYYQTIQPLAGTQGAHYEILLRMLDEEGRIVPPGTFIPAAERYGLMPAIDRWVIENTFATLGRLYRGDAKKRLHTCAINLSGTSWADESLAGFICGMTGRHGVPARSICFEITETAAISNLGKTIALIRDLKEAGFRFSLDDFGSGVSSFGYLKQLPVDYLKIDGGFVRNIIHDKIDHAMVAAINQIGHIMGIKTIAEFVENEEILERITAMGVDYAQGYAIARPQPLDHINLASAPVLQQ
>NZ_AP021884.1|WP_147070049.1|2893538_2894183_-|methyltransferase-domain-containing-protein
MQAAEYDAWYQTPRGRWVGETESDLLRRMLGPQSGESLLDVGCGTGFFTRRFARGSRSAVTGLDPNRDWLAFAERHAVSTENYVNGSALALPFDAGGFDLVMAVTALCFISDQRLALTEMLRVARRRIALGLLNRHSLLYWQKGRGGGQGAYRGAHWHTAAQVRELFAGQPVRNLRMAFSIFVPGGGWIAQQLESVLPTSLPLGSFFVVTADVV
>NZ_AP021884.1|WP_147070029.1|2907798_2908467_-|alpha/beta-fold-hydrolase
MTAFAPLEFVAGSQAVQASVIWLHGLGADGHDFAPVVQALDLPGVRFILPHAPTRPVTINGGHVMPAWYDIRSTGLDADEDAAGLAQSSRVVEDLVAHELARGVASARIIVAGFSQGGALALYAGLAPGRVLGGIMVLSAYLPLMAGFNEWCAAGTHTIPVFMAHGVQDRVVPLQLAERSRQKLVACGFDVEWQIYPMAHSVCEEEIDAIRGWLIRVLQLHV
>NZ_AP021884.1|WP_147070027.1|2908463_2909963_-|hypothetical-protein
MRRIPLVGKLLPAAGEALAVPVRDDPASYSAHEICESIEQLIETLLSARKKNLDWQRHSIDSLHRQDNFSAPFMTRLTQHYLALPPFVSSVSGRFLAAISGYWEEMSAIHLQCVTYLLGHPESRLGALLPLLIQRALYHHAMQMKWRWLRYQLIPSCFWARLHRLYAVAEKHEFARVPLPLPGMERADSCCETLYLRPQMLHSLRPDTLLPCEIEQVDEWIVRWSKSVLLEPMLLSGKHRYGVNLKGASPPRPLAMLNEPGSYRYWGPGLMLAALHAEHDEADAGAHAGWRQALWRRVVNDWSGIPPLRHHPRQMIGKQTELFLGFNEIHTRIDHHPSRRAHDLPYWRRCRVRDESAEGLGLALNTSDGVPVAINSLIGINSGRHFLVGVVCRIRRHESGWTEIGIRRLAANAVPVKLESVNVNLAGQVVDALYLSMAGAFGQRRCVLIPARISWQDGQWQLLCKGRRHLIRLRAPLKATEDYVLADFDGLAQSEAIAS
>NZ_AP021884.1|WP_147070024.1|2909981_2910410_-|hypothetical-protein
MKDFIALLVEQSRLQSVAINPALDDALTHLDHALAGLCAAVQVEYRGPYVGVETPLAHQMVVRRHEWKIHQPAWSMKICVAAPAANCRAEWPVQGVGRLRKALVVKALPAFFAGFAEAIKQAGKQDSSAGLRVLELSRRFNL
>NZ_AP021884.1|WP_147070022.1|2910437_2912018_+|sigma-54-interacting-transcriptional-regulator
MRAQIRANWRKYYHTTRRAVRARSATRTAGNLAQSGQNANNAKEGTNVSLQGISAKPSLLIVDDDPLITDTLNFVLSRDFEVFVADSRSQVKSLLTQLDTPPQLALVDLGLPPLPHKPDEGFHLISELLGYSPGIKILVLSGQNDETNARHARALGAIDFVGKPCEPAQIKSLLFNALLIQDVERSAETEAPAAENLIVGTSFNLDRLRQQITQYANAPFPVLIEGESGSGKELVAASLHKLSGRTKKPYLALNCAAISPTLVEPTLFGYCKGAFTGATSNRAGYFEDACDGTLFLDEIGELPLELQAKLLRVLENGEFQRVGETQSRFSNARVVTATNRDLRQEIKAGRFRADLYHRLSVFGIAVPPLRELGEDKVRLLEHFREFYAREARVKPFALDNRARQMWEDYHFPGNVRELRNIVIRLTTKCAGQNVTAEQLETELDTDTAFPSEIPLPNDGKALYDTARRHLQTLANFSLDQTMKQWEKSYVEAALNLTHGNLSQAAKILGINRTTLYSRMQTYTNEA
>NZ_AP021884.1|WP_147070020.1|2912147_2913497_+|AAA-family-ATPase
MYHEFFGLKEAPFRITPDTGFFFSGGERGAILQGLAYAIRQGEGIIKVTGEVGSGKTMLCWMLEQHLPDHIETVYLANPNVKPEDVLPSILAELELVRPADASRAGHLRTLNDYLLARHDAGKQVVMFVEEAQGMTLDTLEEIRLLSNLETEREKLLQIVLFGQPELDAKLADPRIRQLRERITTAITLAPLTPDAIRAYLAFRLTTAGYRGPDLFDRRAVRSIARASRGLTRRVNILADKSLLAAYTDNTRTIQPRHIRIALRDSAFNDDANKPQRWLLPVIAMGVMVAVLASFYWRSKPAAAPSRQTQTRPAAGLPGRASAAAPDPVAPLSADPFQQRLAATRTWLMQQPADTRTIQLSLLNSPSEFAAYLRGEGGGLAPDQLRIFRTQAQGHPSWTVIYGSYPTRQTANRALLALPEAVRKRHPYLRTVGGIRNETRQIQQVGEQS
>NZ_AP021884.1|WP_147070265.1|2913576_2915352_+|secretin-N-terminal-domain-containing-protein
MWLPMLAVPLLAGCVPAAMIQPSQGHIQQSSQPATRLADIPPLVKTIPYLPSPRAETQVPTYTIVVDNVPVKDLLFSLARDTKKNIDIGTGITGNVTLNAVNEPLPAILERIARQASIRYRMEGDTLSIMPDTPYLKTYKVNYVNLSRNTSSSIGVAAQIASTGSGAVGAAASGSAQGGNSSSTTVDSQSNNNFWEVLTENVRAILTSTRASTQRAEDKSARLDAERNARADRLEQAQAVARAGAAAPTLYREAFGNTSSSLLQDSKNEVIVNPVAGTVSVLGNERQQQVVQQYLDGVSQSSQRQVLIEATIVEVSLKDQYRAGIDWSRLANGSKGIFFNTMPAATTNLANSLLPFFNIGYRDRNLTATLNLLESFGNLRVLSSPKLMALNNQTALLKVVDNLVYFTVQAQQGTLSSTGTPLQPTTFTTTAKTVPVGLVMSLTPQISESGMVTLDVRPTISRKIGDVSDPNPGLPVSTPNKIPVIQVREMESVLQVGSGQTVILGGLMQDDSDRARDGIPVLSRPQGFGAIFGQHEHNVQKTELVIFLRPTVITNPSLDSDELKFYKRYLPRANAAPEQWHNGADAAGDPQ
>NZ_AP021884.1|WP_147070018.1|2915348_2916524_+|tetratricopeptide-repeat-protein
MSLLLKALKQAGDKSAAGARNPSATLADSLSLEPISGSAPDGTAYTSWDGAAPFKRSTARAAWYTPWLSGQRWLVPAVAVVAALFMLIYGVFVYWQTRTPAALVVTPTPHSAAPAAAPPAAAPAQLAAVPSQESGPPLPEINSAVPDAPAALPPPPVQADPTPQWGSGELIREAPPPRRARTQPGRRETRSALPFSMQTATTHINPQLEAAYQAYQAGHTREARNLYLQIPDGERNVDVQLGLAAIALRDNDTPAAARHYQRVLELDPRNSTANSALIGMMGDADPNASETRLKSLIASQPSSQLYFALGNLYAGQNRWPDAEQAYFEAYQKNAANADYAYNLAVSLEHISQSRAALNYYQKARDLMQPGNVQFDPLRLEARIDQLKARQE
>NZ_AP021884.1|WP_147070016.1|2916529_2918233_+|Flp-pilus-assembly-complex-ATPase-component-TadA
MEARKTLRLGEMLVQQGLITLDQLRIALKEQQHTNLPLGRLLVKLGFITEAVIRDQLAHTIGQTSLDLANVVADPEALKLISEDFARRHHLLPIAFDAQRQVLVVAITDMFNVVALDHLRALLGAGVEVDTVLSGEAQLLEAIDNFYGFELSVDGILREIETGEVDYQSLAMDTEEYTQPVVRLVGSLLVDAVKRGASDIHFEPEHAFLRIRYRIDGVLEQVRSLHKSYWPGIAVRLKVISGMNIAENRAPQDGRLSLTLHGRPIDFRVSSQPTIHGENIVLRVLDREKSIIPLANMDLPTDTHTALQRMMARPEGILIITGPTGSGKTTTLYSLLTHLNNETVNIMTLEDPVEYPVTLMRQSSVNETLKLDFANGIRSIMRQDPDIILVGEIRDRDTAEMAFRAAMTGHQVFTTLHTNSALGAFPRLLDIGIVPDIMAGNIIGVVAQRLVRVLCPHCRAAYTPDADEQKLLDWQATDRRPVYRAVGCPACNGKGYRGRMALMELLRMDSELDDLVARRATHREILNAALMRGYRSLAVDGISRVLEGKTSLAEVSRVVDLTQRILS
>NZ_AP021884.1|WP_147070015.1|2918246_2919452_+|type-II-secretion-system-F-family-protein
MPYFSYRAVDQIGRTNRGSLSAANEVDLELRLRRMGLDLITLRQMDSRASGFARGAASRRDLITFCFHLEQISRAGIPILDGVRDLRDSMDNPRFRDILTALLEDMEGGRLMSQALAAHPAVFDTVIVNLVRAGEQTGLMREVFENLGASLKRQDELAAQTRRLLIYPTLVLSMVGIIILLLLLFLVPQIADLIKNMGIALPIQTRVLLWLSETLRTWWPLFLILPVAIGSALVVTLRASERARFVADDVKLRLPVIGPILQKIALARFSNFFALMYRSGITILDALRAGEDIAANRVIADAIRRAGGRIGNGEGLTESFQSLSVFPPLVIRMLRVGETTGALDTALENVSYFYTREVSESIEKSLKILEPALTVVLGLVMAVIVGSVLLPMYDVIGTLKP
>NZ_AP021884.1|WP_147070013.1|2919448_2920984_+|hypothetical-protein
MMFAPQLLVYVCAWSITVACRRAGKIRLVGQFNADEGGRRAFAAVLQAFKNSPVSVMVDGVDEDYRLETLPHVLGNARREMLERRLRQISRNALFSAAWPQGREASGRRDDRYLFISLSNHDAVRPWLDLLHQHGVHLAELTVLPAISHVLLQRIQPTEPHVLLVSEHCGGLRLSYFEHGNLRFSRLTAPESLAEGHAPDLASEINKTDLYLNSQRLMPRDAQLAVYVLDPENAYAGLCREISAENKNLICQAVGSVALAKLVGVDEPLLHRTADVAYLAVLGRSRAAVNLAPAAYTRGYVQLMLRHKLYTGAFAVLATALAISGYLFSRQHDLEQQRLVTQDRIQQQASLYRAVQLALPRAPTSPQNLKRVVETARALYAAPQPMSDFARVSQALETVPDIAVLRLRWLDHDAADTTATHSAVSDNPGAAVRALYFDGEVSPFQGDYKTALASIEHFAATLRNDPGVAEVRVLALPINTDPTATLDESQHTGNSAPRARFRLKLLMRPAR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP021884_2	2.1\|1831723\|33\|NZ_AP021884\|CRISPRCasFinder	1831723-1831755	33	NC_007766	Rhizobium etli CFN 42 plasmid p42f, complete sequence	395837-395869	6	0.818
NZ_AP021884_2	2.1\|1831723\|33\|NZ_AP021884\|CRISPRCasFinder	1831723-1831755	33	NZ_CP020911	Rhizobium etli strain NXC12 plasmid pRetNXC12e, complete sequence	526121-526153	6	0.818
NZ_AP021884_2	2.1\|1831723\|33\|NZ_AP021884\|CRISPRCasFinder	1831723-1831755	33	NC_021911	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1f, complete sequence	601591-601623	6	0.818
NZ_AP021884_3	3.13\|2645871\|34\|NZ_AP021884\|PILER-CR,CRISPRCasFinder,CRT	2645871-2645904	34	MN692973	Marine virus AFVG_117M33, complete genome	35754-35787	9	0.735
NZ_AP021884_3	3.1\|2644999\|36\|NZ_AP021884\|PILER-CR,CRISPRCasFinder,CRT	2644999-2645034	36	NC_008043	Ruegeria sp. TM1040 megaplasmid, complete sequence	694259-694294	10	0.722
NZ_AP021884_3	3.10\|2645653\|35\|NZ_AP021884\|PILER-CR,CRISPRCasFinder,CRT	2645653-2645687	35	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1356140-1356174	10	0.714

1. spacer 2.1|1831723|33|NZ_AP021884|CRISPRCasFinder matches to NC_007766 (Rhizobium etli CFN 42 plasmid p42f, complete sequence) position: , mismatch: 6, identity: 0.818

ttgcgttggatacctcatcctcatcattgcgct---	CRISPR spacer
ctgcgtcggctacctcatcctcatca---cgcttgc	Protospacer
.*****.** ****************   ****

2. spacer 2.1|1831723|33|NZ_AP021884|CRISPRCasFinder matches to NZ_CP020911 (Rhizobium etli strain NXC12 plasmid pRetNXC12e, complete sequence) position: , mismatch: 6, identity: 0.818

ttgcgttggatacctcatcctcatcattgcgct---	CRISPR spacer
ctgcgtcggctacctcatcctcatca---cgcttgc	Protospacer
.*****.** ****************   ****

3. spacer 2.1|1831723|33|NZ_AP021884|CRISPRCasFinder matches to NC_021911 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1f, complete sequence) position: , mismatch: 6, identity: 0.818

ttgcgttggatacctcatcctcatcattgcgct---	CRISPR spacer
ctgcgtcggctacctcatcctcatca---cgcttgc	Protospacer
.*****.** ****************   ****

4. spacer 3.13|2645871|34|NZ_AP021884|PILER-CR,CRISPRCasFinder,CRT matches to MN692973 (Marine virus AFVG_117M33, complete genome) position: , mismatch: 9, identity: 0.735

aacaatttcttgctggataaaatcaagccgctta	CRISPR spacer
tacaatttcgttctggataaaatcaagtgttgca	Protospacer
 ******** * ***************.  . .*

5. spacer 3.1|2644999|36|NZ_AP021884|PILER-CR,CRISPRCasFinder,CRT matches to NC_008043 (Ruegeria sp. TM1040 megaplasmid, complete sequence) position: , mismatch: 10, identity: 0.722

atggtgcgatcctgttgttgctggttgtgctgcggg	CRISPR spacer
tcgctccgatcctgttgtggctggtggtgctgatca	Protospacer
 .* * ************ ****** ******   .

6. spacer 3.10|2645653|35|NZ_AP021884|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 10, identity: 0.714

accggttcatcgccgtgccgcctgtccatcgccgc	CRISPR spacer
gtccagccgtcgccgtgccccctggccatcgccgg	Protospacer
..* . .*.********** **** *********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

622875 : 631682

Vibrio_phage(16.67%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_147070750.1\|622875_624762_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.2e-36	31.7
WP_147070752.1\|624832_626566_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	1.2e-62	33.8
WP_147070754.1\|626615_627062_-	GatB/YqeY domain-containing protein	A0A292GL36	Xanthomonas_phage	7.7e-19	45.8
WP_124706067.1\|627100_627313_-	30S ribosomal protein S21	NA	NA	NA	NA
WP_147070756.1\|627419_628457_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	2.2e-93	53.8
WP_147070758.1\|628446_629247_-	hypothetical protein	NA	NA	NA	NA
WP_147070760.1\|629259_629880_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_147070762.1\|629925_630312_+	dihydroneopterin aldolase	NA	NA	NA	NA
WP_147070764.1\|630313_631213_-	site-specific tyrosine recombinase XerD	A0A0K2CP59	Brevibacillus_phage	4.4e-29	29.9
WP_147070766.1\|631184_631682_-	methylated-DNA--[protein]-cysteine S-methyltransferase	A0A0G2Y1B6	Acanthamoeba_polyphaga_mimivirus	1.4e-13	41.1

DBSCAN-SWA_2

751882 : 760457

Staphylococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_147074510.1\|751882_752905_-	recombinase RecA	A0A0S2MVG1	Bacillus_phage	2.8e-117	64.6
WP_147074509.1\|752981_753476_-	nicotinamide-nucleotide amidohydrolase family protein	B5TK85	Pseudomonas_phage	1.4e-24	43.4
WP_147074508.1\|753472_753961_-	phosphatidylglycerophosphatase A	NA	NA	NA	NA
WP_147074507.1\|753941_754901_-	thiamine-phosphate kinase	NA	NA	NA	NA
WP_147074506.1\|754949_755387_-	transcription antitermination factor NusB	NA	NA	NA	NA
WP_147074505.1\|755383_755851_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2I2L4Y7	Orpheovirus	2.3e-13	33.6
WP_147074504.1\|755911_757003_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	5.1e-48	35.6
WP_147074503.1\|756999_757596_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.9e-25	38.5
WP_147074502.1\|757597_758737_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	1.3e-41	34.9
WP_147074501.1\|758693_759143_-	transcriptional repressor NrdR	NA	NA	NA	NA
WP_147074500.1\|759212_760457_-	serine hydroxymethyltransferase	A0A219Y950	Aeromonas_phage	5.4e-94	51.0

DBSCAN-SWA_3

882982 : 892137

uncultured_Mediterranean_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_147071127.1\|882982_884263_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	1.7e-95	54.9
WP_147071312.1\|884262_885555_-	AAA family ATPase	G3MBE0	Bacillus_virus	2.1e-77	39.6
WP_147071125.1\|885581_886199_-	outer membrane lipoprotein chaperone LolA	NA	NA	NA	NA
WP_147071123.1\|886347_888633_-	DNA translocase FtsK 4TM domain-containing protein	S5VNE3	Mycobacterium_phage	6.2e-80	47.2
WP_147071121.1\|888744_889701_+	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	1.5e-59	42.0
WP_147071119.1\|889708_890254_+	Smr/MutS family protein	A0A0P0IDT4	Acinetobacter_phage	2.1e-10	28.8
WP_147071117.1\|890274_890736_+	redoxin domain-containing protein	NA	NA	NA	NA
WP_147071115.1\|890736_892137_+	PhoH family protein	A0A2I7SAD7	Vibrio_phage	3.9e-77	39.3

DBSCAN-SWA_4

1605656 : 1613255

uncultured_Mediterranean_phage(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_147073445.1\|1605656_1606676_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2H4UW22	Bodo_saltans_virus	2.5e-33	40.1
WP_147073443.1\|1606685_1609043_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_147073441.1\|1609050_1609356_+	integration host factor subunit alpha	A0A0H3UZA0	Geobacillus_virus	1.4e-11	40.0
WP_147073439.1\|1609333_1609708_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_147073437.1\|1609908_1610652_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	7.9e-69	51.4
WP_147073435.1\|1610648_1611311_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	2.3e-35	50.6
WP_147073482.1\|1611315_1612326_+	peptidoglycan DD-metalloendopeptidase family protein	D2J077	Enterococcus_phage	5.8e-06	46.8
WP_147073433.1\|1612328_1613255_+	RNA polymerase sigma factor RpoS	A0A2I7SAT0	Vibrio_phage	7.4e-32	34.6

DBSCAN-SWA_5

1977054 : 2023954

Acidithiobacillus_phage(45.45%)

head,portal,terminase,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_024973176.1\|1977054_1977318_+	hypothetical protein	K4I3X3	Acidithiobacillus_phage	1.6e-24	65.5
WP_024973177.1\|1977329_1977812_+	hypothetical protein	K4HZ96	Acidithiobacillus_phage	4.8e-51	63.6
WP_024973178.1\|1977808_1978657_+	ATP-binding protein	K4HZX9	Acidithiobacillus_phage	1.2e-108	71.0
WP_024973179.1\|1978662_1979289_+	hypothetical protein	K4ICM8	Acidithiobacillus_phage	4.5e-73	67.5
WP_147073311.1\|1979299_1980154_+	hypothetical protein	A0A0S2SYC0	Pseudomonas_phage	2.6e-23	44.9
WP_147073309.1\|1980150_1980651_+	hypothetical protein	K4I3X7	Acidithiobacillus_phage	2.0e-68	73.6
WP_147073307.1\|1980647_1981385_+	hypothetical protein	K4HZA0	Acidithiobacillus_phage	6.0e-109	75.4
WP_147073305.1\|1981381_1981636_+	hypothetical protein	K4I1D6	Acidithiobacillus_phage	6.7e-20	63.6
WP_147073303.1\|1981632_1983924_+	hypothetical protein	K4HZY1	Acidithiobacillus_phage	2.5e-286	63.5
WP_147073301.1\|1984052_1984517_+	crossover junction endodeoxyribonuclease RuvC	K4ICN3	Acidithiobacillus_phage	1.5e-57	71.1
WP_147073299.1\|1984518_1984728_+	hypothetical protein	NA	NA	NA	NA
WP_147073297.1\|1984720_1985137_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_147073341.1\|1985452_1986862_+	ParB N-terminal domain-containing protein	K4I3Y2	Acidithiobacillus_phage	4.3e-164	60.3
WP_147073295.1\|1986858_1988130_+	ParB N-terminal domain-containing protein	A0A2H4JGF1	uncultured_Caudovirales_phage	4.0e-230	92.7
WP_147073293.1\|1988093_1988462_-	hypothetical protein	A0A2H4JI44	uncultured_Caudovirales_phage	7.4e-60	88.3
WP_147073291.1\|1988560_1988920_-	hypothetical protein	NA	NA	NA	NA
WP_147073289.1\|1988949_1989474_-	DUF3489 domain-containing protein	A0A2H4JE21	uncultured_Caudovirales_phage	3.0e-38	83.0
WP_147073287.1\|1989572_1989770_-	hypothetical protein	NA	NA	NA	NA
WP_147073285.1\|1989887_1990427_+	elements of external origin	A0A2H4JCL4	uncultured_Caudovirales_phage	3.0e-86	93.3
WP_147073339.1\|1990429_1992394_+\|terminase	phage terminase large subunit family protein	A0A2H4JIC6	uncultured_Caudovirales_phage	0.0e+00	88.4
WP_147073283.1\|1992411_1992903_+	hypothetical protein	A0A0F6WCR7	Sinorhizobium_phage	3.2e-26	49.1
WP_147073281.1\|1992902_1993295_+	hypothetical protein	NA	NA	NA	NA
WP_146463160.1\|1993294_1993516_+	hypothetical protein	A0A2H4JCJ9	uncultured_Caudovirales_phage	3.1e-13	60.3
WP_147073279.1\|1993515_1995027_+\|portal	phage portal protein	A0A1B2LRR5	Wolbachia_phage	1.3e-150	57.0
WP_147073277.1\|1995036_1996272_+	S49 family peptidase	K4HZZ6	Acidithiobacillus_phage	2.3e-65	41.1
WP_147073275.1\|1996290_1996668_+\|head	head decoration protein	A0A1B2LRT0	Wolbachia_phage	5.5e-26	48.8
WP_058719286.1\|1996685_1997705_+\|capsid	major capsid protein	Q9JMM2	Wolbachia_phage	7.7e-131	66.8
WP_147073273.1\|1997701_1998004_+	hypothetical protein	NA	NA	NA	NA
WP_147073272.1\|1998008_1998455_+	hypothetical protein	NA	NA	NA	NA
WP_147073270.1\|1998460_1998655_+	hypothetical protein	NA	NA	NA	NA
WP_147073268.1\|1998651_1999404_+	hypothetical protein	A0A2D2W2E0	Stenotrophomonas_phage	3.9e-47	44.6
WP_147073266.1\|1999415_1999817_+	hypothetical protein	NA	NA	NA	NA
WP_147073264.1\|1999813_2000017_+	hypothetical protein	NA	NA	NA	NA
WP_147073263.1\|2000022_2000667_+	hypothetical protein	NA	NA	NA	NA
WP_147073261.1\|2000670_2004714_+	tape measure protein	A0A0P0ZCJ4	Stx2-converting_phage	4.2e-31	29.5
WP_147073260.1\|2004724_2005132_+	hypothetical protein	A0A0M4UTA7	Ralstonia_phage	1.2e-29	50.0
WP_147073258.1\|2005133_2008697_+	hypothetical protein	A0A0M4U447	Ralstonia_phage	2.1e-236	40.7
WP_147073256.1\|2008720_2009986_+	hypothetical protein	NA	NA	NA	NA
WP_147073254.1\|2009989_2011075_+	hypothetical protein	NA	NA	NA	NA
WP_147073252.1\|2011071_2011467_+	hypothetical protein	Q6VSZ7	Vibrio_phage	2.3e-06	33.8
WP_147073250.1\|2011470_2013486_+	hypothetical protein	A0A0M4UKC5	Ralstonia_phage	6.5e-57	40.2
WP_147073248.1\|2013478_2013700_+	hypothetical protein	NA	NA	NA	NA
WP_147073246.1\|2013776_2014079_+	hypothetical protein	K4I011	Acidithiobacillus_phage	4.4e-26	65.3
WP_147073244.1\|2014075_2014552_+	hypothetical protein	K4ICR8	Acidithiobacillus_phage	1.8e-74	87.8
WP_170227448.1\|2014548_2015016_+	lysozyme	K4I410	Acidithiobacillus_phage	2.3e-66	78.6
WP_147073241.1\|2015009_2016134_-	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	NA	NA	NA	NA
WP_147073239.1\|2016133_2018365_-	AAA family ATPase	K4I1H4	Acidithiobacillus_phage	2.7e-27	32.2
WP_147073237.1\|2018373_2019096_-	hypothetical protein	NA	NA	NA	NA
WP_147073235.1\|2019092_2021114_-	BREX-3 system phosphatase PglZ	NA	NA	NA	NA
WP_147073232.1\|2021110_2023954_-	DEAD/DEAH box helicase family protein	A0A2H4J643	uncultured_Caudovirales_phage	8.6e-47	26.3

DBSCAN-SWA_6

2044160 : 2053121

Acidithiobacillus_phage(66.67%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_147073207.1\|2044160_2045429_-	AAA family ATPase	V9QJ85	Oenococcus_phage	1.4e-09	33.9
WP_147074826.1\|2046046_2046667_+	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	NA	NA	NA	NA
WP_147074827.1\|2046659_2047664_+	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_147074828.1\|2047657_2048110_-	LacI family transcriptional regulator	NA	NA	NA	NA
WP_147074829.1\|2048106_2049462_-	recombinase family protein	K4ICM1	Acidithiobacillus_phage	2.9e-141	56.5
WP_147074830.1\|2049458_2049965_-	DUF2924 domain-containing protein	K4I3X1	Acidithiobacillus_phage	1.2e-20	40.8
WP_147074831.1\|2050160_2050604_+	hypothetical protein	B7SYF8	Stenotrophomonas_phage	1.3e-34	52.1
WP_147074832.1\|2050818_2052342_+\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	2.5e-149	53.8
WP_147074833.1\|2052353_2053121_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	3.7e-77	57.0

DBSCAN-SWA_7

2294456 : 2305315

Escherichia_phage(33.33%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_147074479.1\|2294456_2295875_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	2.1e-46	29.2
WP_147074455.1\|2296030_2296915_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	2.7e-23	32.7
WP_147074454.1\|2296911_2297454_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	3.3e-48	55.0
WP_147074453.1\|2297456_2298341_-	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	2.8e-97	63.0
WP_147074452.1\|2298337_2299402_-	dTDP-glucose 4,6-dehydratase	A0A1D7XFE8	Escherichia_phage	4.2e-87	47.7
WP_161984264.1\|2299421_2300312_-	peptidyl-prolyl cis-trans isomerase, EpsD family	NA	NA	NA	NA
WP_147074450.1\|2300501_2302757_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	4.9e-170	42.1
WP_124705779.1\|2302757_2303066_-\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	7.4e-13	44.4
WP_124705778.1\|2303300_2303504_+	cold-shock protein	A0A2H4N7Y6	Lake_Baikal_phage	4.7e-24	79.4
WP_147074449.1\|2303639_2303861_+	hypothetical protein	NA	NA	NA	NA
WP_147074448.1\|2303870_2304074_+	hypothetical protein	NA	NA	NA	NA
WP_147074447.1\|2304076_2305315_-	NADP-dependent isocitrate dehydrogenase	Q77Z09	Phage_21	9.6e-11	63.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP021884

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection