CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP047146	Streptomyces sp. GS7 chromosome, complete genome	13 crisprs	c2c9_V-U4,csa3,cas3,cas14k,DEDDh,WYL,cas1,casR,Cas14u_CAS-V,DinG	2	1	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP047146_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_1

417608-417712

Orphan

Consensus_repeat	Method
TGGCGCAAGAGCAGCTACAGCAACGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP047146_1

>merge|NZ_CP047146|1|417608-417712|CRISPRCasFinder
TGGCGCAAGAGCAGCTACAGCAACGGTGATGGCGGAGCCTGCATAGAGGTGGCCGAGGGGTTCCCCGGCGGCGCTCGCTGGCGTAAGAGCAGCTACAGCAACGGT

>NZ_CP047146|1|1|417608-417712|CRISPRCasFinder
TGGCGCAAGAGCAGCTACAGCAACGGT	GATGGCGGAGCCTGCATAGAGGTGGCCGAGGGGTTCCCCGGCGGCGCTCGC
TGGCGTAAGAGCAGCTACAGCAACGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159503086.1\|409757_410237_+\|DUF1453-family-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159503093.1\|421695_423759_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP047146.1\|WP_159503083.1\|406770_407058_+\|DUF4229-domain-containing-protein	unknown	unknown	gnl\|CDD\|379415
NZ_CP047146.1\|WP_159503084.1\|407560_408925_+\|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl\|CDD\|224220
NZ_CP047146.1\|WP_159509645.1\|411924_412557_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP047146.1\|WP_159509647.1\|419273_420107_+\|menaquinone-biosynthesis-protein	unknown	unknown	gnl\|CDD\|270352
NZ_CP047146.1\|WP_159503091.1\|417865_418177_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159509643.1\|410540_411128_+\|DUF3995-domain-containing-protein	unknown	unknown	gnl\|CDD\|372505
NZ_CP047146.1\|WP_159503085.1\|409039_409657_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379409
NZ_CP047146.1\|WP_159509649.1\|427807_428698_-\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NZ_CP047146.1\|WP_159503089.1\|416736_417591_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP047146.1\|WP_159503088.1\|414014_415937_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341233
NZ_CP047146.1\|WP_158690127.1\|418189_418327_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|172774
NZ_CP047146.1\|WP_003984261.1\|418739_418943_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP047146.1\|WP_159503082.1\|406149_406674_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP047146.1\|WP_159503087.1\|412602_413544_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159503092.1\|420188_421277_-\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|366286
NZ_CP047146.1\|WP_159503094.1\|423989_425189_+\|dehypoxanthine-futalosine-cyclase	unknown	unknown	gnl\|CDD\|274731
NZ_CP047146.1\|WP_159503096.1\|426755_427454_+\|demethylmenaquinone-methyltransferase	unknown	unknown	gnl\|CDD\|234689
NZ_CP047146.1\|WP_159503095.1\|425478_426069_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_158690127.1\|418189_418327_-\|hypothetical-protein	gnl\|CDD\|172774	PRK14286, PRK14286, chaperone protein DnaJ; Provisional.	0.000270718
NZ_CP047146.1\|WP_159503093.1\|421695_423759_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.1045e-88
NZ_CP047146.1\|WP_159503092.1\|420188_421277_-\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|366286	pfam00756, Esterase, Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.	1.39558e-10
NZ_CP047146.1\|WP_159503084.1\|407560_408925_+\|cation:dicarboxylase-symporter-family-transporter	gnl\|CDD\|224220	COG1301, GltP, Na+/H+-dicarboxylate symporters [Energy production and conversion].	3.23919e-113
NZ_CP047146.1\|WP_159509645.1\|411924_412557_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	7.14345e-13
NZ_CP047146.1\|WP_159509643.1\|410540_411128_+\|DUF3995-domain-containing-protein	gnl\|CDD\|372505	pfam13160, DUF3995, Protein of unknown function (DUF3995). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 138 and 149 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.	1.53292e-07
NZ_CP047146.1\|WP_159503085.1\|409039_409657_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|379409	pfam13977, TetR_C_6, BetI-type transcriptional repressor, C-terminal. This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C-terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	6.70522e-18
NZ_CP047146.1\|WP_159509649.1\|427807_428698_-\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	7.62212e-56
NZ_CP047146.1\|WP_159503089.1\|416736_417591_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	0.00143468
NZ_CP047146.1\|WP_159503088.1\|414014_415937_+\|AMP-binding-protein	gnl\|CDD\|341233	cd05907, VL_LC_FACS_like, Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases. This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.	0
NZ_CP047146.1\|WP_159503082.1\|406149_406674_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.25941e-10
NZ_CP047146.1\|WP_003984261.1\|418739_418943_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.74223e-36
NZ_CP047146.1\|WP_159509647.1\|419273_420107_+\|menaquinone-biosynthesis-protein	gnl\|CDD\|270352	cd13634, PBP2_Sco4506, The conserved hypothetical protein SCO4506 exhibits the type 2 periplasmic-binidng protein fold. This group includes the SCO4506 protein from Streptomyces coelicolor and related hypothetical proteins. SCO4506 is an ortholog of Ttha1568 (MqnD) from Thermus thermophilies HB8. MqnD is an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. SCO4506 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.61034e-107
NZ_CP047146.1\|WP_159503083.1\|406770_407058_+\|DUF4229-domain-containing-protein	gnl\|CDD\|379415	pfam14012, DUF4229, Protein of unknown function (DUF4229). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 122 amino acids in length.	4.32257e-16
NZ_CP047146.1\|WP_159503094.1\|423989_425189_+\|dehypoxanthine-futalosine-cyclase	gnl\|CDD\|274731	TIGR03699, menaquin_MqnC, dehypoxanthine futalosine cyclase. members of this protein family are involved in menaquinone biosynthesis by an alternate pathway via futalosine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0
NZ_CP047146.1\|WP_159503096.1\|426755_427454_+\|demethylmenaquinone-methyltransferase	gnl\|CDD\|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	7.25919e-125

>NZ_CP047146.1|WP_159503089.1|416736_417591_+|helix-turn-helix-domain-containing-protein
MPARKDVDGSASVPAFYGAELRWKREAAGLTLRETVEGSYFGETYLSEIEHGKRRMPVELACHVDRLLKTDGYFERRCADVRKARRAGHAEYFERILEAEKHADTIEDWAPTLIPGVLQTAPYGRALVLAEHPNATEEEVEEKVNARLARACLFESDHKTPEFWAILHESLLRQSILPPGEMAEQLDSIAALVRRRRIVVQVIPWNSGPHPLMLGPAIILTFLDAPPLVYTESSYSGATTDDPALVRRYRKAYDRLRAAAMPPEASLATIEAAAEDYRNGKQPD
>NZ_CP047146.1|WP_159503088.1|414014_415937_+|AMP-binding-protein
MFNQDSAPPAPAPAVPQLVQPHRVLVEGVVREVSVPPLAPPVRTGSLGDIPFTNAAEAPHETVLSRRQPSGAWRDITAAEFAGEVRAVAKGLIAHGLEPGDRLAIMARTTYEWTLLDFAAWAAGLVTVPIYPTSSAYQAQWILQDSAARACVVETVDEARLISAVRTHLPALGNLWQFNTGAVAQLVDAGRDLPDEAVDARRAAVAPPALATLVYTSGTTGRPKGCALTHANFFAEVDNAVELLHPVFRSVSDEPAATLLFLPLSHVFGRMVAVGCLRARVRLGHAPSIQTDELLADLAGFRPTFLLAIPYVLEKVFNTGRATAEKMGRAASFDRAARIARAYGEAVEAREHGTGPGPGVGLRAARKLYDPLVYRRIRSALGGRVRYAICGGSPLGHRLAAFYSGAGIEIFEGYGLTETTAAATVTPPLRPRIGTVGWPLPGSAVRIADDGEILLRGGHVFSGYWDAELGAARPATDRDGWLPTGDIGALDADGYLAITGRKKEIIVTSGGKNVAPAPLEDRLRSHPLVGQCMVVGDNRPYVTALITLEPDGLSHWRQMTRKRDTPLTELVRDERLLADIQHAVDDANKLVSRAESIRRFAVLPADFSEQTGHLTPSLKLRRALVARDFAKEIDQLYESQ
>NZ_CP047146.1|WP_159503087.1|412602_413544_-|hypothetical-protein
MKTTRISPASRISLRAICTAALLAGAMAVPAAAFAGTPGQQERPASTGAAHSAPQAPAKGKVRAVDIGGGMEAVIHNGVCDLQAIGSGRPFATLRKGQSYTNGIHVYFDGRNVSARSQGERTHGKVKPNPARTVRLSNGAQATVQKVNGSYTAKIQVRNKRIATLDSAHRSVTHQGVRYTVNPKDGKVAVQRMKKRQMLHRMTHRVIHVRAHHLQRPHFQRPVTSYAQTPAASPAQPTANYATYASPAQQPVTGQTPFGGQAQTPMYGQAQTPMVGQAQTPMYGGGWMHRSRHGASAGAMAMSYSAAGSSSGR
>NZ_CP047146.1|WP_159509645.1|411924_412557_+|TetR-family-transcriptional-regulator
MLDAAVRTFARRGYRAASMDEIAEGAGVSKPLVYLYLNSKEELFSAVIRRESAALVAAVTAAVEPDAAADRQLWSGLKGFFAHTAEHPDGWAVLHQQARTQGEPFAVEVAAMRAEIVRFVTVLIGAAAKEAGCDGELADREVAGLAHALVGAAESLAEWANARTADGTSAFGFSGERERPTAKDTAATLMNFVWAGLGRLMAGERWAPGG
>NZ_CP047146.1|WP_159509643.1|410540_411128_+|DUF3995-domain-containing-protein
MTSLRRETASSLARWPGYAAAVWGFAFAVPSFYWAMGGLAGAASTISPSLVELARERNPGFITVLWVTGVLKVVGGMLGLSLVRRRTWGRGMNRLLQLTAWGAGVLLVWHGALFVGQGLLVQTHVIALAPELLPVSRWYTYLWGPWFVAGGLTFVFAARTHLSGAADRRDAMIAGIVGGLGALALSATALIAGIG
>NZ_CP047146.1|WP_159503086.1|409757_410237_+|DUF1453-family-protein
MNPWLLTAIIVVLVIAVVIKRRIGEPVNARELFGAPVILTGIGVMSLVKMTGVTGTDYAWVVSGAVLGAALGALRGTTIELTDRNGALWQRYTGRTFLVMVGSLVAMAGFNVLAVRMGMHEGARPVQLSLGVSFLGESLVVGRRGMLSGIPFTPAARGR
>NZ_CP047146.1|WP_159503085.1|409039_409657_-|TetR-family-transcriptional-regulator
MPKIVDPEARRRAVAQAVLTVVARHGLEHASLRNVAEEAGLAIGSIRHYFADHDELMTFTMRELSRRIGERIRTHAERLLAPDADIDRRAATEELLAEFLPLDDTRREEAVLWITFTAATHTRAELRPHAAEMQQDMHALIVRVLSEAQRMGGLPAGLDADLEAHRLAALLDGLTLQAALLPDRMPPEQQRQVLRRHLDALTSGR
>NZ_CP047146.1|WP_159503084.1|407560_408925_+|cation:dicarboxylase-symporter-family-transporter
MSTSAQTPASAQAPQSPRSSRIPKIPFWVQILAGLALGVLLGWIAKSGDVGWLGSTLEHIGSLFVQLLKLAVAPLVFFAILVSITNLRQVNNAARLATRTLLWFMATSLIAVAIGLAIGLLTHPGAGTGLTPKDGKLPQHTGSWIDFLTGIVPTDVITPFTQLNVLQIVFIAAVAGIAALQLGEKAEPVLTISRAALELLQKALWWVIRLAPIGTVGLIGHAIATYGWNLIGKYATFTVDIYVGCALVLFGVYPLLLSTVAKVNPLQFFRGAWPAIQLAFVSRSSVGTMPVTQKVTERLGVPKEYASFAVPFGSTTKMDGCASIYPAIAAIFIAQIFNVHLSIADYVLIAFVSVIGSAATAGLTGATVMLTLTLSTLGLPLEGVGLLMAIDPILDMMRTATNVAGQSVIPILVSAREKILDRDAYAHATSIRIGDNDTTDAEPEKVSVSVPAAA
>NZ_CP047146.1|WP_159503083.1|406770_407058_+|DUF4229-domain-containing-protein
MSSPKFATLRYTALRIGLFVACFAVVWVLAYFGIIPLGVGNSNTIWLLLLAIVISAPLSFVLLRKQRDAMSEQIVAKVDRQKERLAANQSMEDGL
>NZ_CP047146.1|WP_159503082.1|406149_406674_+|GNAT-family-N-acetyltransferase
MNVRFDLDPSVTPEVRDGICALWADVSNAGGAVGFVPPVTREDIRPDLLGHLTELAKGRKRLLTGRDEDGRVVATAFLSLNPHRLMTHWLWVYTVMVHPSLQGRGTGRALMAAVEESARGIDGITGIRLTCRGGTGLPRFYEACGYKEVGRVPGAIKVAEGDFRDDVTMWRQLG
>NZ_CP047146.1|WP_159503091.1|417865_418177_-|hypothetical-protein
MAAFSRNGKPVGLDAQYVGKLPCAGCGLRPMKLPGRDGGVCIPCYAEERTAAGRRAASAGSWVAASFVGDPCLACGSRSVDANGWAFWCNSCQMQTAVALPPR
>NZ_CP047146.1|WP_158690127.1|418189_418327_-|hypothetical-protein
MSENMPPQKPCPDCGGAGTVEWETPGGHKVTTQCSGCAGTGTVLA
>NZ_CP047146.1|WP_003984261.1|418739_418943_-|cold-shock-protein
MATGTVKWFNAEKGFGFIAQDGGGPDVFVHYSAINASGFRSLEENQQVNFDVTQGPKGPQAENVTPV
>NZ_CP047146.1|WP_159509647.1|419273_420107_+|menaquinone-biosynthesis-protein
MGHIQFLNCLPLYWGLARTGTLLDLDLTKDTPEKLSEQLVRGDLDIAPITLVEFLRAADDLVAFPDLAVGCDGPVMSCVIVSQKPLEQLDGARVALGSTSRTSVRLAQLLLAEKIGVRPEYYRCPPDLGLMMQEADAAVLIGDAALRANLHDGPKLGLDVHDLGQMWKDWTGLPFVFAVWAARRDYLEREPEVVEKVHEAFLASRDLSLEEVGKVAEQAARWEHFDEAVLERYFTTLDFRFGADQLRGVTEFARRVGPTTGFPADVSVELLAGARRA
>NZ_CP047146.1|WP_159503092.1|420188_421277_-|prolyl-oligopeptidase-family-serine-peptidase
MHHRPRPKFRRRGRRTSESPRPKWRLSLLTAFIAILGLGAYPAVKYMDVLNDTGEPMSFSQTIPDGVPGPPQPAAADPSVRMPTGPRAQFRTASTLSDGTKIGVTTLHGKKSGFTGDVWVWAPKEYYEDRYRSSAFPVLLALPGSYGYPTNYWTGPDLKLQRTISDLVAQGRSKPFIVAMPVLNPGKRYYDGSDIPGQPKMGTWISDDVPDLVKANFRTFTSRDGWAIMGSSSGGFVGLKQVLQHPDRFKAVIASGPDTRPDSPLWRGHEKEKRANDPERLARQLAARPGAPDVYLQFQIGTRESGRANLERFIRQYAKGPVKAHLHVIEDGGHDAKSYIRGMRDASLEAISKVLSGPTPSP
>NZ_CP047146.1|WP_159503093.1|421695_423759_+|protein-kinase
MEPLAGEDPRVLGGYRLLGRLGAGGMGRVYLGRSAGGRTVAVKVVHAQFAADEQFRARFRREIESARRVGAAWTAPVLDADPDASVPWIATGYAAGPSLAQAVGAFGPLAEHSVRALGAGLAEALTAVHALGLVHRDVKPSNVLLTLDGPLLIDFGIARATDGTASLTATGVSVGSPGYMAPEQILGKGATGAADVFSLGAVLAFAATGVPPFPGDSSASLLYKVVHEEPELGPQLDGELRELVAGCLAKDPARRPAPEGVAARLAGDRIGGAAGLVRDGWLPAPVVEQVSRQAVELLNLEVEQREQGEVREHQEDREERAGAPGAAGTAGTAGVPSGTFGPPDPSYGAVSGLIPFDAPVQVEAEAPADRPGGLGTPLPRPTPAAPPSVPLTPTPPSAPPSTSSSTPPSVAPPETAWPSAGAPPATPHASGATDIGGAADRADPSGAAAVASTSDAAAVPSAPDAAAVADLPTGPPSPSPFPSSPSAPKERRIALAGAVGGRDRPRRVSCTLVLSVAGALAAATTAGFVFTLMRNGGGNGATATQPPSGHTASAQPSEPAQGTGQGTGEAVGDVPHSFLGTWSGGITMANGIPNGSMTSVIKAGHQGEFVVRTTYDALLVRCRAKAKLLSATDTELVLQESSDGTQGPGCTGNTSTVTYTLGKDGALTFTSDDKRGGTPKATLEKSG
>NZ_CP047146.1|WP_159503094.1|423989_425189_+|dehypoxanthine-futalosine-cyclase
MTENADLQSVLDRAAQGGRITPEEALDLYRSAPLHALGQAADAVRRRRYAGTEHIATYIIERNINYTNVCVTACKFCAFYAAPKDTAKGWTRDLDDILRRCAETVELGGTQIMFQGGHHPDYGVEYYEEHFSAIRKAFPQLVIHSLGASEVEHMARISKVSVEEAISRIHAAGLDSFAGAGAELLPARPRKAIAPLKESGERWLEIMETAHKLGVESTSTMLMGTGETNAERIEHLRMIRDVQDRTGGFRAFIPYTYQPENNHLKGQTQATLFEYLRMIAIARIFLDNVAHIQGSWLTTGKEIGQLSLHYGADDLGSIMLEENVVSSAGAKHRSNRLEIIDLIRKADRVPAQRATTYEHLVVHDDPANDPVDDRVVSHLSSTAIEGGTAHPELKLIETN
>NZ_CP047146.1|WP_159503095.1|425478_426069_+|hypothetical-protein
MLTLHRVRAVRFAEGGEPAPGHAVVVDGARLAAIGPYEELLAAYGMGVPPAQAKPGAWGRARVREWDGVLTPGRHEPDGAAFLEATYHPDPREAAELGSEPLTGAALAALDMPETRWGASARRGLQRLLATGTTSLTGPFARPAVRTAVRRSGIEELPGPRPLPLAAGGPANFAIFAPDGTCLATVIAGRLVHRRR
>NZ_CP047146.1|WP_159503096.1|426755_427454_+|demethylmenaquinone-methyltransferase
MTRASLDKQPHEVAAMFDDVAARYDITNDVLSLGQARLWRKEVDRAVAARPAERVLDLAAGTGTSSLPFAASGAYVVPCDFSVGMLAEGKKRHPWLPFAAGDGTRLPFADGVFDAVTISFGLRNIQDTDVALAELYRVTKPGGRVVICEFSEPTWAPFRTVYTEYLMRALPPVARAVSSNPDAYVYLAESIRTWPNQPELAARLQAVGWTKVAWRNLTGGVVALHRGTKPAD
>NZ_CP047146.1|WP_159509649.1|427807_428698_-|D-alanyl-D-alanine-carboxypeptidase
MKGIKGIRRASAVAITAGAVLTAGAFTSPAQAAALPTPTINAPGGFVMNNGTGATLFSKTADTRRATGSTTKIMTARVVLAQKNLDLDSKVTIQKAYSDYIVNNNWASSAHLIVGDKVTVRQLLYGLMLPSGCDAAYALADKFGSGSTREARVTSFIGQMNATAKSLGLKNTHFDSFDGIGRGKNYSTPRDLTKIASSAMKFSTFRTVVGTKSTKQKVTTQSGGYRYMSWTNTNNLLSSYKGTIGVKTGSGPEAKYCLVFAATRGGKTVIGTVLASSSIDTRTADAKKLMDYAFKK

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Crispr_ID: NZ_CP047146_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_2

1193753-1193903

Orphan

Consensus_repeat	Method
ATCTGCCTGCTGCTGGTGGCGGTGGTCGGGTTGAAGGCGACGTCGGGGCACTGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP047146_2

>merge|NZ_CP047146|2|1193753-1193903|CRISPRCasFinder
ATCTGCCTGCTGCTGGTGGCGGTGGTCGGGTTGAAGGCGACGTCGGGGCACTGATGCTGGCTGGGGGTCCGGGGGTTGTCCCCCGGGAGGTGCGGTATCTGCCTGCTGCTGGTGGCGGTGGTCGGGTTGAAGGCGACGTCGGGGCACTGAT

>NZ_CP047146|2|2|1193753-1193903|CRISPRCasFinder
ATCTGCCTGCTGCTGGTGGCGGTGGTCGGGTTGAAGGCGACGTCGGGGCACTGAT	GCTGGCTGGGGGTCCGGGGGTTGTCCCCCGGGAGGTGCGGT
ATCTGCCTGCTGCTGGTGGCGGTGGTCGGGTTGAAGGCGACGTCGGGGCACTGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159503584.1\|1203559_1203808_+\|DUF3311-domain-containing-protein	unknown	unknown	gnl\|CDD\|371707
NZ_CP047146.1\|WP_159503580.1\|1198234_1199260_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213234
NZ_CP047146.1\|WP_159503576.1\|1191807_1192275_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NZ_CP047146.1\|WP_078894626.1\|1192998_1193301_+\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|197951
NZ_CP047146.1\|WP_159503573.1\|1188591_1189251_-\|HNH-endonuclease	unknown	unknown	unknown
NZ_CP047146.1\|WP_159503577.1\|1192547_1192868_+\|DUF3618-domain-containing-protein	unknown	unknown	gnl\|CDD\|378834
NZ_CP047146.1\|WP_159503574.1\|1189876_1190383_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159503586.1\|1205362_1206427_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226765
NZ_CP047146.1\|WP_159503578.1\|1193960_1196198_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NZ_CP047146.1\|WP_159503571.1\|1187102_1187738_+\|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl\|CDD\|234648
NZ_CP047146.1\|WP_159503583.1\|1201659_1203009_+\|DUF445-family-protein	unknown	unknown	gnl\|CDD\|377281
NZ_CP047146.1\|WP_159509760.1\|1197449_1198214_+\|transporter	unknown	unknown	gnl\|CDD\|253605
NZ_CP047146.1\|WP_159503582.1\|1200040_1201351_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238868
NZ_CP047146.1\|WP_159503570.1\|1186682_1187093_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159503572.1\|1187935_1188595_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|379158
NZ_CP047146.1\|WP_159503575.1\|1190382_1191657_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP047146.1\|WP_159503585.1\|1203804_1205385_+\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271357
NZ_CP047146.1\|WP_159503579.1\|1196569_1197358_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226953
NZ_CP047146.1\|WP_159503581.1\|1199269_1200025_+\|DUF1707-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959
NZ_CP047146.1\|WP_159503569.1\|1185799_1186531_+\|ribonuclease-PH	unknown	unknown	gnl\|CDD\|178914

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159503584.1\|1203559_1203808_+\|DUF3311-domain-containing-protein	gnl\|CDD\|371707	pfam11755, DUF3311, Protein of unknown function (DUF3311). This is a family of short bacterial proteins of unknown function.	2.17643e-08
NZ_CP047146.1\|WP_159503580.1\|1198234_1199260_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213234	cd03267, ABC_NatA_like, ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA. NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.	1.48907e-121
NZ_CP047146.1\|WP_159503576.1\|1191807_1192275_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	4.22802e-68
NZ_CP047146.1\|WP_078894626.1\|1192998_1193301_+\|co-chaperone-GroES	gnl\|CDD\|197951	smart00883, Cpn10, Chaperonin 10 Kd subunit. The chaperonins are 'helper' molecules required for correct folding and subsequent assembly of some proteins. These are required for normal cell growth, and are stress-induced, acting to stabilise or protect disassembled polypeptides under heat-shock conditions. Type I chaperonins present in eubacteria, mitochondria and chloroplasts require the concerted action of 2 proteins, chaperonin 60 (cpn60) and chaperonin 10 (cpn10). The 10 kDa chaperonin (cpn10 - or groES in bacteria) exists as a ring-shaped oligomer of between six to eight identical subunits, while the 60 kDa chaperonin (cpn60 - or groEL in bacteria) forms a structure comprising 2 stacked rings, each ring containing 7 identical subunits. These ring structures assemble by self-stimulation in the presence of Mg2+-ATP. The central cavity of the cylindrical cpn60 tetradecamer provides as isolated environment for protein folding whilst cpn-10 binds to cpn-60 and synchronizes the release of the folded protein in an Mg2+-ATP dependent manner. The binding of cpn10 to cpn60 inhibits the weak ATPase activity of cpn60.	8.46691e-25
NZ_CP047146.1\|WP_159503577.1\|1192547_1192868_+\|DUF3618-domain-containing-protein	gnl\|CDD\|378834	pfam12277, DUF3618, Protein of unknown function (DUF3618). This domain family is found in bacteria, and is approximately 50 amino acids in length.	6.01614e-08
NZ_CP047146.1\|WP_159503586.1\|1205362_1206427_-\|hypothetical-protein	gnl\|CDD\|226765	COG4315, COG4315, Uncharacterized protein conserved in bacteria [Function unknown].	1.08343e-20
NZ_CP047146.1\|WP_159503578.1\|1193960_1196198_-\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	5.28497e-138
NZ_CP047146.1\|WP_159503571.1\|1187102_1187738_+\|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	7.61696e-100
NZ_CP047146.1\|WP_159503583.1\|1201659_1203009_+\|DUF445-family-protein	gnl\|CDD\|377281	pfam04286, DUF445, Protein of unknown function (DUF445). Predicted to be a membrane protein.	6.98059e-133
NZ_CP047146.1\|WP_159503582.1\|1200040_1201351_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	4.51722e-83
NZ_CP047146.1\|WP_159503585.1\|1203804_1205385_+\|sodium:solute-symporter-family-protein	gnl\|CDD\|271357	cd10322, SLC5sbd, Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain. This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.	3.80603e-53
NZ_CP047146.1\|WP_159503572.1\|1187935_1188595_-\|HNH-endonuclease	gnl\|CDD\|379158	pfam13392, HNH_3, HNH endonuclease. This is a zinc-binding loop of Fold group 7 as found in endo-deoxy-ribonucleases and HNH nucleases.	0.000106668
NZ_CP047146.1\|WP_159509760.1\|1197449_1198214_+\|transporter	gnl\|CDD\|253605	pfam06182, ABC2_membrane_6, ABC-2 family transporter protein. This family acts as the transmembrane domain (TMD) of ABC transporters. The family includes proteins responsible for the transport of herbicides.	6.28944e-50
NZ_CP047146.1\|WP_159503579.1\|1196569_1197358_+\|ABC-transporter-permease	gnl\|CDD\|226953	COG4587, COG4587, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.83377e-29
NZ_CP047146.1\|WP_159503569.1\|1185799_1186531_+\|ribonuclease-PH	gnl\|CDD\|178914	PRK00173, rph, ribonuclease PH; Reviewed.	6.51828e-169
NZ_CP047146.1\|WP_159503581.1\|1199269_1200025_+\|DUF1707-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	2.52374e-20
NZ_CP047146.1\|WP_159503575.1\|1190382_1191657_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.53293e-37

>NZ_CP047146.1|WP_078894626.1|1192998_1193301_+|co-chaperone-GroES
MLHDRVLVRTDIPEGERRSTGGIVIPATAAVGRRLAWAEVVAVGQNVRTVEVGDRVLYDPEDRAEVEVRGVAYVLMRERDLHAVAAERLEGADDATGLYL
>NZ_CP047146.1|WP_159503577.1|1192547_1192868_+|DUF3618-domain-containing-protein
MSEARTPAQIEADIVRRRQALAVTLDEIGVRLHPKTIVGDAKAKAAQAVDRTAGRAYVAAHRALSDMRGQLVSEDGAPRLERIIPVAVIGVAVVGLLALGSRKRRD
>NZ_CP047146.1|WP_159503576.1|1191807_1192275_-|thioredoxin-dependent-thiol-peroxidase
MSERLQPGDNAPAFTLPDADGKQVSLADHKGRKVIVYFYPAALTPGCTKQACDFTDNLDFLAGHGYDVIGISPDKPEKLATFREKEDLKVTLLGDPEKEVLTAYGAFGEKKLYGKTVTGVIRSTVILDEDGKVERALYNVKATGHVAKIIKDLGL
>NZ_CP047146.1|WP_159503575.1|1190382_1191657_+|HAMP-domain-containing-protein
MGIRGRIALAISCMTALAVVVLGFAVHHIAGNERERSARAYQDERLSSALQIYERDGTLALGAQLDDAALPPPLRAAVFHNRSGTYLSGGEDPRVWAATGVGGDGARPARSLSVSAAYPSDDPAQVALDRALLIAGCGTVVLMAGVSWFVAQRLSRRLRLSAAAARRIAAGEPPDADALASNGRDEVAELGRSVHHMATSLAARVEAEREFTADVAHELRTPVAGLVAAAELLPQQRAVELVRDRAQAMRRLVEDLLEVSRLDAGVERADLDACELPSLVRGIVTRAARQRGVDDLSVSVTVEGEPRIVETDRRRVERVLVNLLANAAKHGKPPIEVVVAGSRIVVRDHGPGYPAELCAEGPRRFRTAAPERGTGHGLGLTIAAGQAEVLGARLEFGAAAEGGAEAVLELPDRAVVVAPEPAAP
>NZ_CP047146.1|WP_159503574.1|1189876_1190383_+|hypothetical-protein
MTDREGSRWRRGRTALVAFVVVTALAAGGVWFSQASERASAVDAAPKTSAVQDVKSDGQPTAGLPGVRDCGIGEPEIKPRVITLTCADAGMVATGITWTRYDSEEAEGKGVVQVEKTAAGVGTDSGYRATFRLYGAKEVDGARAFTGLEVTYEGSTPLGDTTEMYNLA
>NZ_CP047146.1|WP_159503573.1|1188591_1189251_-|HNH-endonuclease
MALKYSRERLAAAAHVSSSYDEVVRWFGSTPTPGNRRYVRAKLREAGIDTAHFTPPGVRHTEARLRDAVTCSRSVAEVVRRLGLDPVGGHHTHIGRRIRSLGIDTSHFSPQGRRNPSARRRLSPEELLVKTETLIRRVPSSRLRVAMLAYGAEERCALCGTGPSWRHRPMLLEVDHANGDWRDNRRGNLRFLCPNCHATTDSYRGRGKRKHSGRAEGEQ
>NZ_CP047146.1|WP_159503572.1|1187935_1188595_-|HNH-endonuclease
MSRSVRYTRELLTEAAAHCTDIDGVIAFCGGRSYHQVRRHLLRRFAHFGIDVSHFQPVTRRTARPRPTKEALHQAIDASISVASALRHLGYPVTSRNRALFTQWVSEHAISTDHFLGQAHGRGKPGTTPVKPPEQILVKRSGQRRAQTVMLRRALRQIGVPERCAECGTGPVWLGRPMTLEIDHINGDRSDDRRENLRLICPNCHAMTDTWCRGGRRRR
>NZ_CP047146.1|WP_159503571.1|1187102_1187738_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MQPQTGGHPAPPRRLVLATRNAGKISELRAILEAAGLGVELVGADAYPDVPDVKETGVTFAENALLKAHALARATGHPAVADDSGLCVDVLGGAPGIFSARWAGRHGDDRANLDLLLAQLSDIADEHRAAHFACAAALALPDGSERVVEGTLDGTLRHTPTGTGGFGYDPILQPLGETRTCAELTPAEKNAISHRGKAFRALAGVVGELLG
>NZ_CP047146.1|WP_159503570.1|1186682_1187093_+|hypothetical-protein
MARPHLRRTAAPALAALAAATLAVPLLSGCGAVQKAMDCAKTATAVVNGVDKLQKAADNALDDPQEANKALDEIDTSLKKVGNSAHDPDLAKAIDKMNTGIKNARTSIDADKAPDLKPIGEAADEMTTICTPGHTG
>NZ_CP047146.1|WP_159503569.1|1185799_1186531_+|ribonuclease-PH
MSRIDGRTPEQLRPVTIERGWSKHAEGSVLVSFGDTKVFCTASVAEGVPRWRKGTGEGWVTAEYAMLPRSTNTRGDRESVRGKIGGRTHEISRLIGRSLRAVIDFKALGENTIVLDCDVLQADGGTRTAAITGAYVALADSISWAQGKKLIKHGRQPLTGTVSAVSVGIVGGVPLLDLCYEEDVRAETDMNVVCTGDGRFVEVQGTAEAEPFARDELNSLLDLAVTGCATLDTTQREALARTL
>NZ_CP047146.1|WP_159503578.1|1193960_1196198_-|penicillin-binding-protein
MSDDPQGDGAGPEPRPRRTGWRRAVPTWRMVAGSVLLFLLLIVGGLVAGYLLVGIPPANSAAKAQSNVYLYSDGSELARDGDVNRENVPLSHVPRTVQRAVLAAEDRDFHSESAVDPAAMVRAAWNTVTGKGKQSGSTITQQYVKNYYLGQEQTLTRKAKEFFIAIKLDREVSKDKILEGYLNTSYYGRNAYGIQAAAQAYYSKTSDKLTTAEGAYLAALLNAPSAYDITAHPENKPRAVARWNYVLDGMVKKKWLSRTERAAMTFPPLGKAKASHGLSGQRGYLVEAAKDYLTDHGILDESTLRAGGYRITTTIDRKRQNAFVKAVDTQLMDKLSDTRKVDGYVRAGGASIDPATGRVVALYGGIDYAKQYVNGATRHDYQVGSTFKPLVFAAAVQNNSTTQDGTRITPNTVYDGTDKRMTVSRGRPTGFAPANEDDRSYGPITVTEATDKSVNSVYAQMGIDVGPDTVKNTAIALGIPAKTPSLASSRGAVSLGTATPSVLDMTQVYATLARHGSQLPYTLVDSVTKSGEDVELPDREQTTAVSRAAADTTTQILQSVVDGGTAQAAQAAARPAAGKTGTAEDDKAAWFAGYTPELATVVAVLGQNPDNAAQEPLYGAAGQPRLNGGDFPAQIWADYTAAALNGRPVRDFDLQLEEGAEQSATPEPSGSTPESPSGSASPSTGPTDTGNPTATTAPPGTGTPTGPTGVPTPPQFPTAGPPTGPTQSFPTFVPNADDLAAYPGD
>NZ_CP047146.1|WP_159503579.1|1196569_1197358_+|ABC-transporter-permease
MLYGAVVAGSFRRYATYRVATAAGVVTNTAFGFIIAYTYLALWSQRPHLGGYDRAQALTFVWAGQALFALIAYGGLDELQDRIRNGDVAVDLYRPADLQLWWLATELGRAGLQLIGRGVVPMAVGALAFPLALPGSALTWGWFLLSVALGVVVSFALRYLVALASFWLLDSSGLAMVSMLSCMFFSGLVLPLRVFPGALADLAQLLPWAALLQVPADVLMEARTGGALLRGLAFQAAWAVVLLALGRLVQSAATRKVVVQGG
>NZ_CP047146.1|WP_159509760.1|1197449_1198214_+|transporter
MWVRATLAYRTSFLLTAFGNFAASGLDFVAILLMFSRIRALGGFSLPEVAFLYGTCSLALGLSDLLLGNLSRLGARIRDGTLDTLLVRPAPVFVQIAADRFALRRLGRTFQALLVLGWALGRIDVDWTVGRVLMVPLMAVCGTAIFGAVYTAGAAFQFWAQDAAELQNSLTYGGNALLQYPPTVFARDLVRGVTFIVPLAFVNWLPALWLLDRPDPLGLPRWVAFLGPAVAALMCAGAGLAWRRGVRSYRSTGS
>NZ_CP047146.1|WP_159503580.1|1198234_1199260_+|ATP-binding-cassette-domain-containing-protein
MEGKLPVSGDPLIELDGVEKVFTVRRRAGRLRRTKHEVRAVDGITFRVPRGEMVGYIGPNGAGKSTTIKMLTGILVPSGGRLRVAGVDPARERTRLTRRIGVVFGQRTTLWWDLPLKDSYDLVRRMYRVPDAVYRANLARCVELLDLAPLLDVPVRQLSLGQRMRGDIAAALLHDPEVLYLDEPTIGLDVVSKAKVRSFLREVNAERGTTVLLTTHDLTDIEQLCRRVMVIDHGRLVHDGDLAGLRAAADGERMLVVDLARELPPIEGVPGARTVKVEGPRQWLAFPATGSAAPLVAAVADRFPLVDLSVREPDIEALIAELYAGGGAARREAGDAHPGAL
>NZ_CP047146.1|WP_159503581.1|1199269_1200025_+|DUF1707-domain-containing-protein
MTDERLPQLRASDADRERVAEILRDALAEGRLDMAEFDERFDATYQARTYGELERITADLPAGAPAPPSLRKEPAAGGAVDAVGPVTAWPERIRPDVQGSTSGVGIMGGFERKGRWTIGRRFTAICCMGGGELDLREANFAAPEVEISVFALMGGVNVIVPPGVEVETRGLGIMGGFDSREDGTPGEPGAPRVIVTGVALMGGVGVERKLPKEERLRLKAERREEQLRLRSGRREERRRLRDERRGRRELE
>NZ_CP047146.1|WP_159503582.1|1200040_1201351_-|SGNH/GDSL-hydrolase-family-protein
MNRRVGYTLLAGMAAVVVLISAAIFAGFDGERGTPGSAPHAPHPPAAPAASGRWVGTWSAAAASAEPGTQDGYAQMSIRNVVHTSVGGTDARIQLSNLFGTRPLTFSHASLALAAGTGDPTAAAGTMRRLSFGGEHSVTIPIGGQITSDPVRLAVPGDADLLVTTYSPAPSGPATYHPYARQTSYLARGDRTEDATGTAYTEQSPYWRYLTGVDVWSTRAQGTVVALGDSITDGITSTPGANHRWTDFLAARLRDEPDVPRYGVLNEGISGNRLLINGSRYSPTNGPSALARLDRDALSRAGVKAVVVEIGLNDLFKSPRQLDPDKVLAGMRRLVREAHARGVRVIGSTLTPFGAHRGYSHRLNAVRERVNRVIRSGSVYDDVIDFDKALRDPDEPEQLRASYDSGDHLHPSDRGYRAMADAVDLDRLRRRAPEAL
>NZ_CP047146.1|WP_159503583.1|1201659_1203009_+|DUF445-family-protein
MDDTKAQVSRMAPPAAPVAGGAPAGRPAGPGGFRYSAADEEKRQAVRRMKTLATCLLLAVALVYVLAKWAGAAGAGGWTGFVAAAAEAGMVGALADWFAVTALFKRPLGLPIPHTAIIPTKKDQLGRSLGDFVGENFLSGEVVRRRLRSVGIGARLGGWLAEPHNADRVTAELSAALRGALTVLRDSDVQAVVGEAITRRADAQEIAPGLGTLLEKVVSEGGHTRVVDLVCARAHDWLVEHGDSVMAAVSGGAPGWTPRFVDRKVGDRVYKELLRFVTEMRDMPEHPARGAVDRFLKDFAGDLQTDPGTREKVERLKSQVLGRGEVQDLIASAWGSVRAMIVAAAEDERSELRLRTRAALLSLGQRLAADGRLQGKVDGWLEGAAVYVVTTYQGEITSLITDTVAGWDAEHTSKKIEAHIGRDLQFIRINGTVVGALAGLCIYAVSQAF
>NZ_CP047146.1|WP_159503584.1|1203559_1203808_+|DUF3311-domain-containing-protein
MGRGKAQRNGAAAWLLLPYVLFLAVLPLVNRVTPTVAGLPFLFFWMLLATLLTPLAVWLAWRGDLRRARSQAPGPADERGRG
>NZ_CP047146.1|WP_159503585.1|1203804_1205385_+|sodium:solute-symporter-family-protein
MNATVATTIFAAFMVLTVALGLLAVRGRGAATEGQPEGLPGKGGGGRRAGLTEWSVGGRSLGTVFIWVLMAGESYTSFSYLGAAGWGYNFGAPVLYVLAYMSCGYAIGYVVGPMLWAYARRHGLVGITDIVAHRYRRPWLGAAVAVLATVCLLPYIQLQITGMGVVVSTISYGAISLNWAYFIGFAVTTGFVVVSGLRGSAWVSVLKDLLVIVTLGFLAVYVPLHYFGGYGPLLHRIVAEKPGWLTFPGHRSGGLGQVWFITTTLVNSLTVVVFPTTVAGYLGARNADALRRNAIYLPFYNVLLFVPMLLGLAALFVVPGLAGADSNLALFKLVVDSLPAWAVGVVGVAAALSSIVPMAVFMLVIGTMWGRSVLGAIPRLATRQKLWSQLVVVAAGGLALVLTYTAPTTLVRLSLISYEGMAQLVPMLLLGLVWRRLTVYAAVSGLTAGFALVCVLVFGGHDPVWGMNAGIVGLALNAAVALTVTWLGPREAGDDRPDGEVLALDDGFPRGGVPAPGGPVSTPVSR
>NZ_CP047146.1|WP_159503586.1|1205362_1206427_-|hypothetical-protein
MPVTTPPSARRHAVLAVTALAAALTLTTACGSNGSGHAAGTGSGTDNVQPAGQGSSDYGTGYGSTTSGYGGQAGGDSGKPAAAGKPAGALALHQSDTLGPVVTDAQGMTLYRFDKDTAKPPTSNCSGDCATTWPPVPADGATAPAGIAPDALGSVTRADGTKQLTIGGWPAYRFAKDTKPGDTKGHGVGGTWHALASDGTKAGTQQPGDVGVFAQPQLGKILVDGMGRTLYRFNKDSAWPMKFGCNDTCLDTWKPAKPADRSKLNGISPHLVSTVTRPDGTRQLAIDCWPVYWFTGDKQPGDINGQGKMGLWFAVSDNGKKNTKTPSGTSSSGAASGNTPSDTPSSDVTATPAY

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Crispr_ID: NZ_CP047146_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_3

1203462-1203564

Orphan

Consensus_repeat	Method
ACGGCGGGTAAGCCGAAAACGTGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP047146_3

>merge|NZ_CP047146|3|1203462-1203564|CRISPRCasFinder
ACGGCGGGTAAGCCGAAAACGTGGGAAGTCAGCCCAGCGCGCAGCGACTAGGCTCGGGCGACGTGCGAAAACGGACCTACGGCGGGAAAGCCGAAAACGTGGG

>NZ_CP047146|3|3|1203462-1203564|CRISPRCasFinder
ACGGCGGGTAAGCCGAAAACGTGGG	AAGTCAGCCCAGCGCGCAGCGACTAGGCTCGGGCGACGTGCGAAAACGGACCT
ACGGCGGGAAAGCCGAAAACGTGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159503580.1\|1198234_1199260_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213234
NZ_CP047146.1\|WP_159503585.1\|1203804_1205385_+\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271357
NZ_CP047146.1\|WP_159503591.1\|1212710_1214600_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|223953
NZ_CP047146.1\|WP_078894626.1\|1192998_1193301_+\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|197951
NZ_CP047146.1\|WP_159503577.1\|1192547_1192868_+\|DUF3618-domain-containing-protein	unknown	unknown	gnl\|CDD\|378834
NZ_CP047146.1\|WP_159503586.1\|1205362_1206427_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226765
NZ_CP047146.1\|WP_159503578.1\|1193960_1196198_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NZ_CP047146.1\|WP_159503587.1\|1206527_1208132_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|224806
NZ_CP047146.1\|WP_043264497.1\|1193485_1193806_+\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|171110
NZ_CP047146.1\|WP_159503583.1\|1201659_1203009_+\|DUF445-family-protein	unknown	unknown	gnl\|CDD\|377281
NZ_CP047146.1\|WP_159503582.1\|1200040_1201351_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238868
NZ_CP047146.1\|WP_159503589.1\|1210270_1211674_-\|DUF1996-domain-containing-protein	unknown	unknown	gnl\|CDD\|370451
NZ_CP047146.1\|WP_159509760.1\|1197449_1198214_+\|transporter	unknown	unknown	gnl\|CDD\|253605
NZ_CP047146.1\|WP_159503588.1\|1209127_1210183_+\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225306
NZ_CP047146.1\|WP_159503590.1\|1211929_1212586_-\|DUF4142-domain-containing-protein	unknown	unknown	gnl\|CDD\|379301
NZ_CP047146.1\|WP_159503593.1\|1215310_1216300_+\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|376730
NZ_CP047146.1\|WP_159503581.1\|1199269_1200025_+\|DUF1707-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959
NZ_CP047146.1\|WP_159509761.1\|1208128_1208743_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159503579.1\|1196569_1197358_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226953
NZ_CP047146.1\|WP_159503592.1\|1214766_1215072_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159503580.1\|1198234_1199260_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213234	cd03267, ABC_NatA_like, ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA. NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.	1.48907e-121
NZ_CP047146.1\|WP_159503585.1\|1203804_1205385_+\|sodium:solute-symporter-family-protein	gnl\|CDD\|271357	cd10322, SLC5sbd, Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain. This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.	3.80603e-53
NZ_CP047146.1\|WP_159503591.1\|1212710_1214600_-\|AMP-binding-protein	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	4.87063e-155
NZ_CP047146.1\|WP_078894626.1\|1192998_1193301_+\|co-chaperone-GroES	gnl\|CDD\|197951	smart00883, Cpn10, Chaperonin 10 Kd subunit. The chaperonins are 'helper' molecules required for correct folding and subsequent assembly of some proteins. These are required for normal cell growth, and are stress-induced, acting to stabilise or protect disassembled polypeptides under heat-shock conditions. Type I chaperonins present in eubacteria, mitochondria and chloroplasts require the concerted action of 2 proteins, chaperonin 60 (cpn60) and chaperonin 10 (cpn10). The 10 kDa chaperonin (cpn10 - or groES in bacteria) exists as a ring-shaped oligomer of between six to eight identical subunits, while the 60 kDa chaperonin (cpn60 - or groEL in bacteria) forms a structure comprising 2 stacked rings, each ring containing 7 identical subunits. These ring structures assemble by self-stimulation in the presence of Mg2+-ATP. The central cavity of the cylindrical cpn60 tetradecamer provides as isolated environment for protein folding whilst cpn-10 binds to cpn-60 and synchronizes the release of the folded protein in an Mg2+-ATP dependent manner. The binding of cpn10 to cpn60 inhibits the weak ATPase activity of cpn60.	8.46691e-25
NZ_CP047146.1\|WP_159503577.1\|1192547_1192868_+\|DUF3618-domain-containing-protein	gnl\|CDD\|378834	pfam12277, DUF3618, Protein of unknown function (DUF3618). This domain family is found in bacteria, and is approximately 50 amino acids in length.	6.01614e-08
NZ_CP047146.1\|WP_159503586.1\|1205362_1206427_-\|hypothetical-protein	gnl\|CDD\|226765	COG4315, COG4315, Uncharacterized protein conserved in bacteria [Function unknown].	1.08343e-20
NZ_CP047146.1\|WP_159503578.1\|1193960_1196198_-\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	5.28497e-138
NZ_CP047146.1\|WP_159503587.1\|1206527_1208132_-\|oxidoreductase	gnl\|CDD\|224806	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion].	8.60342e-40
NZ_CP047146.1\|WP_043264497.1\|1193485_1193806_+\|multidrug-efflux-SMR-transporter	gnl\|CDD\|171110	PRK11431, PRK11431, quaternary ammonium compound efflux SMR transporter SugE.	3.45058e-28
NZ_CP047146.1\|WP_159503583.1\|1201659_1203009_+\|DUF445-family-protein	gnl\|CDD\|377281	pfam04286, DUF445, Protein of unknown function (DUF445). Predicted to be a membrane protein.	6.98059e-133
NZ_CP047146.1\|WP_159503582.1\|1200040_1201351_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	4.51722e-83
NZ_CP047146.1\|WP_159503589.1\|1210270_1211674_-\|DUF1996-domain-containing-protein	gnl\|CDD\|370451	pfam09362, DUF1996, Domain of unknown function (DUF1996). This family of proteins are functionally uncharacterized.	1.5815e-23
NZ_CP047146.1\|WP_159509760.1\|1197449_1198214_+\|transporter	gnl\|CDD\|253605	pfam06182, ABC2_membrane_6, ABC-2 family transporter protein. This family acts as the transmembrane domain (TMD) of ABC transporters. The family includes proteins responsible for the transport of herbicides.	6.28944e-50
NZ_CP047146.1\|WP_159503588.1\|1209127_1210183_+\|PucR-family-transcriptional-regulator	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	1.31778e-17
NZ_CP047146.1\|WP_159503593.1\|1215310_1216300_+\|membrane-protein-insertase-YidC	gnl\|CDD\|376730	pfam02096, 60KD_IMP, 60Kd inner membrane protein.	1.26274e-33
NZ_CP047146.1\|WP_159503581.1\|1199269_1200025_+\|DUF1707-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	2.52374e-20
NZ_CP047146.1\|WP_159503590.1\|1211929_1212586_-\|DUF4142-domain-containing-protein	gnl\|CDD\|379301	pfam13628, DUF4142, Domain of unknown function (DUF4142). This is a bacterial family of unknown function.	3.80511e-16
NZ_CP047146.1\|WP_159503579.1\|1196569_1197358_+\|ABC-transporter-permease	gnl\|CDD\|226953	COG4587, COG4587, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.83377e-29

>NZ_CP047146.1|WP_159503583.1|1201659_1203009_+|DUF445-family-protein
MDDTKAQVSRMAPPAAPVAGGAPAGRPAGPGGFRYSAADEEKRQAVRRMKTLATCLLLAVALVYVLAKWAGAAGAGGWTGFVAAAAEAGMVGALADWFAVTALFKRPLGLPIPHTAIIPTKKDQLGRSLGDFVGENFLSGEVVRRRLRSVGIGARLGGWLAEPHNADRVTAELSAALRGALTVLRDSDVQAVVGEAITRRADAQEIAPGLGTLLEKVVSEGGHTRVVDLVCARAHDWLVEHGDSVMAAVSGGAPGWTPRFVDRKVGDRVYKELLRFVTEMRDMPEHPARGAVDRFLKDFAGDLQTDPGTREKVERLKSQVLGRGEVQDLIASAWGSVRAMIVAAAEDERSELRLRTRAALLSLGQRLAADGRLQGKVDGWLEGAAVYVVTTYQGEITSLITDTVAGWDAEHTSKKIEAHIGRDLQFIRINGTVVGALAGLCIYAVSQAF
>NZ_CP047146.1|WP_159503582.1|1200040_1201351_-|SGNH/GDSL-hydrolase-family-protein
MNRRVGYTLLAGMAAVVVLISAAIFAGFDGERGTPGSAPHAPHPPAAPAASGRWVGTWSAAAASAEPGTQDGYAQMSIRNVVHTSVGGTDARIQLSNLFGTRPLTFSHASLALAAGTGDPTAAAGTMRRLSFGGEHSVTIPIGGQITSDPVRLAVPGDADLLVTTYSPAPSGPATYHPYARQTSYLARGDRTEDATGTAYTEQSPYWRYLTGVDVWSTRAQGTVVALGDSITDGITSTPGANHRWTDFLAARLRDEPDVPRYGVLNEGISGNRLLINGSRYSPTNGPSALARLDRDALSRAGVKAVVVEIGLNDLFKSPRQLDPDKVLAGMRRLVREAHARGVRVIGSTLTPFGAHRGYSHRLNAVRERVNRVIRSGSVYDDVIDFDKALRDPDEPEQLRASYDSGDHLHPSDRGYRAMADAVDLDRLRRRAPEAL
>NZ_CP047146.1|WP_159503581.1|1199269_1200025_+|DUF1707-domain-containing-protein
MTDERLPQLRASDADRERVAEILRDALAEGRLDMAEFDERFDATYQARTYGELERITADLPAGAPAPPSLRKEPAAGGAVDAVGPVTAWPERIRPDVQGSTSGVGIMGGFERKGRWTIGRRFTAICCMGGGELDLREANFAAPEVEISVFALMGGVNVIVPPGVEVETRGLGIMGGFDSREDGTPGEPGAPRVIVTGVALMGGVGVERKLPKEERLRLKAERREEQLRLRSGRREERRRLRDERRGRRELE
>NZ_CP047146.1|WP_159503580.1|1198234_1199260_+|ATP-binding-cassette-domain-containing-protein
MEGKLPVSGDPLIELDGVEKVFTVRRRAGRLRRTKHEVRAVDGITFRVPRGEMVGYIGPNGAGKSTTIKMLTGILVPSGGRLRVAGVDPARERTRLTRRIGVVFGQRTTLWWDLPLKDSYDLVRRMYRVPDAVYRANLARCVELLDLAPLLDVPVRQLSLGQRMRGDIAAALLHDPEVLYLDEPTIGLDVVSKAKVRSFLREVNAERGTTVLLTTHDLTDIEQLCRRVMVIDHGRLVHDGDLAGLRAAADGERMLVVDLARELPPIEGVPGARTVKVEGPRQWLAFPATGSAAPLVAAVADRFPLVDLSVREPDIEALIAELYAGGGAARREAGDAHPGAL
>NZ_CP047146.1|WP_159509760.1|1197449_1198214_+|transporter
MWVRATLAYRTSFLLTAFGNFAASGLDFVAILLMFSRIRALGGFSLPEVAFLYGTCSLALGLSDLLLGNLSRLGARIRDGTLDTLLVRPAPVFVQIAADRFALRRLGRTFQALLVLGWALGRIDVDWTVGRVLMVPLMAVCGTAIFGAVYTAGAAFQFWAQDAAELQNSLTYGGNALLQYPPTVFARDLVRGVTFIVPLAFVNWLPALWLLDRPDPLGLPRWVAFLGPAVAALMCAGAGLAWRRGVRSYRSTGS
>NZ_CP047146.1|WP_159503579.1|1196569_1197358_+|ABC-transporter-permease
MLYGAVVAGSFRRYATYRVATAAGVVTNTAFGFIIAYTYLALWSQRPHLGGYDRAQALTFVWAGQALFALIAYGGLDELQDRIRNGDVAVDLYRPADLQLWWLATELGRAGLQLIGRGVVPMAVGALAFPLALPGSALTWGWFLLSVALGVVVSFALRYLVALASFWLLDSSGLAMVSMLSCMFFSGLVLPLRVFPGALADLAQLLPWAALLQVPADVLMEARTGGALLRGLAFQAAWAVVLLALGRLVQSAATRKVVVQGG
>NZ_CP047146.1|WP_159503578.1|1193960_1196198_-|penicillin-binding-protein
MSDDPQGDGAGPEPRPRRTGWRRAVPTWRMVAGSVLLFLLLIVGGLVAGYLLVGIPPANSAAKAQSNVYLYSDGSELARDGDVNRENVPLSHVPRTVQRAVLAAEDRDFHSESAVDPAAMVRAAWNTVTGKGKQSGSTITQQYVKNYYLGQEQTLTRKAKEFFIAIKLDREVSKDKILEGYLNTSYYGRNAYGIQAAAQAYYSKTSDKLTTAEGAYLAALLNAPSAYDITAHPENKPRAVARWNYVLDGMVKKKWLSRTERAAMTFPPLGKAKASHGLSGQRGYLVEAAKDYLTDHGILDESTLRAGGYRITTTIDRKRQNAFVKAVDTQLMDKLSDTRKVDGYVRAGGASIDPATGRVVALYGGIDYAKQYVNGATRHDYQVGSTFKPLVFAAAVQNNSTTQDGTRITPNTVYDGTDKRMTVSRGRPTGFAPANEDDRSYGPITVTEATDKSVNSVYAQMGIDVGPDTVKNTAIALGIPAKTPSLASSRGAVSLGTATPSVLDMTQVYATLARHGSQLPYTLVDSVTKSGEDVELPDREQTTAVSRAAADTTTQILQSVVDGGTAQAAQAAARPAAGKTGTAEDDKAAWFAGYTPELATVVAVLGQNPDNAAQEPLYGAAGQPRLNGGDFPAQIWADYTAAALNGRPVRDFDLQLEEGAEQSATPEPSGSTPESPSGSASPSTGPTDTGNPTATTAPPGTGTPTGPTGVPTPPQFPTAGPPTGPTQSFPTFVPNADDLAAYPGD
>NZ_CP047146.1|WP_043264497.1|1193485_1193806_+|multidrug-efflux-SMR-transporter
MAWILLAVAGLLEVGWSIGMKFTDGFTRLWPSVFTGAGIVASMLLLSYAARTLPIGTAYGVWVGIGAAGAAVVGMLVLGEPATAARIFFICLLLVAVVGLKATSGH
>NZ_CP047146.1|WP_078894626.1|1192998_1193301_+|co-chaperone-GroES
MLHDRVLVRTDIPEGERRSTGGIVIPATAAVGRRLAWAEVVAVGQNVRTVEVGDRVLYDPEDRAEVEVRGVAYVLMRERDLHAVAAERLEGADDATGLYL
>NZ_CP047146.1|WP_159503577.1|1192547_1192868_+|DUF3618-domain-containing-protein
MSEARTPAQIEADIVRRRQALAVTLDEIGVRLHPKTIVGDAKAKAAQAVDRTAGRAYVAAHRALSDMRGQLVSEDGAPRLERIIPVAVIGVAVVGLLALGSRKRRD
>NZ_CP047146.1|WP_159503585.1|1203804_1205385_+|sodium:solute-symporter-family-protein
MNATVATTIFAAFMVLTVALGLLAVRGRGAATEGQPEGLPGKGGGGRRAGLTEWSVGGRSLGTVFIWVLMAGESYTSFSYLGAAGWGYNFGAPVLYVLAYMSCGYAIGYVVGPMLWAYARRHGLVGITDIVAHRYRRPWLGAAVAVLATVCLLPYIQLQITGMGVVVSTISYGAISLNWAYFIGFAVTTGFVVVSGLRGSAWVSVLKDLLVIVTLGFLAVYVPLHYFGGYGPLLHRIVAEKPGWLTFPGHRSGGLGQVWFITTTLVNSLTVVVFPTTVAGYLGARNADALRRNAIYLPFYNVLLFVPMLLGLAALFVVPGLAGADSNLALFKLVVDSLPAWAVGVVGVAAALSSIVPMAVFMLVIGTMWGRSVLGAIPRLATRQKLWSQLVVVAAGGLALVLTYTAPTTLVRLSLISYEGMAQLVPMLLLGLVWRRLTVYAAVSGLTAGFALVCVLVFGGHDPVWGMNAGIVGLALNAAVALTVTWLGPREAGDDRPDGEVLALDDGFPRGGVPAPGGPVSTPVSR
>NZ_CP047146.1|WP_159503586.1|1205362_1206427_-|hypothetical-protein
MPVTTPPSARRHAVLAVTALAAALTLTTACGSNGSGHAAGTGSGTDNVQPAGQGSSDYGTGYGSTTSGYGGQAGGDSGKPAAAGKPAGALALHQSDTLGPVVTDAQGMTLYRFDKDTAKPPTSNCSGDCATTWPPVPADGATAPAGIAPDALGSVTRADGTKQLTIGGWPAYRFAKDTKPGDTKGHGVGGTWHALASDGTKAGTQQPGDVGVFAQPQLGKILVDGMGRTLYRFNKDSAWPMKFGCNDTCLDTWKPAKPADRSKLNGISPHLVSTVTRPDGTRQLAIDCWPVYWFTGDKQPGDINGQGKMGLWFAVSDNGKKNTKTPSGTSSSGAASGNTPSDTPSSDVTATPAY
>NZ_CP047146.1|WP_159503587.1|1206527_1208132_-|oxidoreductase
MTAPAPAHPLSATADTARLPVLASAPGFPVVAAPLPGLTSVGPPRLLAGLDELPRLDRVAHLTLHGQPPRLSAQELVALAEDTDLRGRGGAGFPFARKVAAVLDGIRRADGRSAVVVNGSEGEPSCLKDTALLLHVPHLVLDGALLAAGAIGARQIAIGVTRPDVADSVRRAIAERGPVRPPLRVTRLPERFVTGEGTALTGGLSGGPALPSGRKVRSSERGLDGLPTLLSNAETYAQLALAARLGALGYRTAGLPTEPGTLLLTVAGRQVVEAAYGTPLLQVLTHCGLDAGQGVLLGGYHGTWLSPDAARTATLSRDALAAHDAVLGAGAVLPLPHDTCPAGETVRVARWMAAESAGQCGPCVLGLPALADQLDRAVRGGGDAALEAVHARLRAVRGRGACSHPDGTARFVASALAAFPEEFDRHAHGFGCGRPVTGALPVTGHRPQPPAPPRYPPPPSAPPPPPPPPERLLVDWTLCRGHGLCAEVVPAMIRLGPDGYPETAGMPLPARMRRRAQLAVRRCPALALRIQSGN
>NZ_CP047146.1|WP_159509761.1|1208128_1208743_-|hypothetical-protein
MLRPALPAALLLFLAVTLHSGAMDSTVHFLDYGAGVLALVSLSATVLWGLAATDRMVLHTPHRLLAQAVHRGTGIAGLGFLGLHIWVKVAQGQTGAAAAAVPFTDGVRPMLIGFGTLAAYGFVAVAVSGAVRGAFTGRSSARWWRALHTVAYPAWALALLHGLKSGRAAAGWAVAGYGIALAGVAVRLALRLRGPRRTTGSEPR
>NZ_CP047146.1|WP_159503588.1|1209127_1210183_+|PucR-family-transcriptional-regulator
MCDLLNRLWAQPRGEWTRVVRNELPDLVEEVVAELQRGFPAMAALLGDTPVEDAQWALEQALLTCLGYQKSSQSKPPAVPSVVTPMPVARARQDLFDVLAGQRETPEGGLGELARAAGWPVPDTVQAVVLATPAEAPQLAAALGHALIGSVDGYAALFVPDPATQTRARLEAALKGRAAAVGHAVPAADAASSLRWARYLLSLAPGRGGPETRPTFVDDHLSALLLLQDESLADALTSRWLGPLAELTPRQNERLEVTLLAWLEGGGAPEAAKLLHVHPQTVRYRLRQIEKLFGPALRDPRTRFELEMALRSRRLMAHVRSRRARAGRRARAVASSIRPLGMAREARVNGL
>NZ_CP047146.1|WP_159503589.1|1210270_1211674_-|DUF1996-domain-containing-protein
MTVAAMALLLGGGALTAIASTALAHNSGPDPVPGHQHLTATAATISCPDVGENLRTVPSGARLQVSQGLASLDRQVSDAYRTMTSGGGSSATLGTLERQRRQTIGAMADAIAHGGAQRPDDLMRMSACTTKPTGTSPDRDLSWRQGQSQSQGRGRNQRQGQQPGQGQSGHHQQTGPSQDDFTDITTVAPGTGGPPFLTPRGRGASTGTFTSACGRNENGHFNSDNVIVTPGVSNGAHHTHDYVGNKTTDAFSTEQSLAASGTTCSNGDLSTYYWPVLRKLDGTTSPKPGAGGDGNSGSVLTPASVTLTYRGSQTGAVRAMPRFLRVITGDAKAFTNGPKNAHASWSCTGFENRQLTDKYPLCPRGSQVVRTLAFPGCWNGRTTDSGNHRDHMAFAGRNGACPQGFTAVPQLVERLTYDVPPGDSFAVDSFPEQLRKPVTDHGDFIDVMPDGLMNRAVGCINGGQTCS
>NZ_CP047146.1|WP_159503590.1|1211929_1212586_-|DUF4142-domain-containing-protein
MRSIPRTRKKSPASGRAIATGLVVCALLATLTALLLPVQLFGESASAATNTVGYDDDGGGTVNTRYGPLTAMDRDFVKKVRLAGLWEMPAGRQAQARGRTAAVRTAGDHLVAGHTELDRRSREAAQQLGIALPNQPTAEQQGWLDQLGAASDENFGPLFAELLRRSHGKVFGLVALVRDQTRNSVVRALADRANAVVLDHITVLEHTGQVDFGTLHST
>NZ_CP047146.1|WP_159503591.1|1212710_1214600_-|AMP-binding-protein
MRDISVPALAAPLRTGGLADSVFDTAAHRPDFAQLARRDADAPGGWREVSAATFRDEVTGLARGLLADGIRPGTRVAVMSRTRYEWTLFSYALWAIGGHVVPVYPTASAEQLRCILTGARVAAIVVENEAQAMTVAEACDATDRDPALRRIWQLDRDCVRRLTEEGTRLPRAEVHRLRHAVAPHSTAAIVHTSGTTGRPRGCVITHANLAAECDTLLAGWGGLLAAPGERPSLLAFLPFAHIYGLMVQVACLRGGVLLGHQPEWASEELLPALASFRPTFLFAVPYVFEKLTTRARLAAEQAGRGRMFDAAMAVAVRHAEAQAARARGTGRGPGPWLRARHALYDRLVYSRLRALLGGRVRTAVSGGSPLRRELGLQYAGAGITVYDGYGLTETSGAITVQPPGRVRFGTVGRPLPGSAVHLALDGEVWVRGAVVFAGYLDDTGLTGGGYRGNSPGLYGGWLPTGDLGRLDEDGYLVITGRKKDVIITSSGSSVAPQALEQRLCAHPLVSQCVVVGDDRPYVAALITLDPEALAHWRRLRIEAAAGDGDPDGSGAAPRVPSPEEELQAEVRRAVARANAAVSRAESIRAFRVLPGEFSQEAGLLTPSLKLRRAAIVKAYASEIDALYAG
>NZ_CP047146.1|WP_159503592.1|1214766_1215072_+|hypothetical-protein
MYRIVDAWRLYTSALFFLLAGLLLAQSGLTTALTAAATAAAILLLCSALALAATARPVPPGRIRTAIRDRERRTAFLPQRDPDAAGRPRPRAPGRALPTAA
>NZ_CP047146.1|WP_159503593.1|1215310_1216300_+|membrane-protein-insertase-YidC
MSVFDVLGDALARGADTLAPLFGASATAVAIVLFTLGVRAALHPLARAAARGEKSRAALAPQIAALQRRHRGDRERLQQAMTELYAKSGASPLAGCLPTALQVPVFFVTYRIFTSGNATLLGHTLLGAPLGGSWRQALADGGVFGPHGLVYLGLFALIGAVATWNYRRARATAAANPAPAAGPGGTAVPGMGTLAKVMPLLSFGTLITVAVVPLAAGLYLVTSTAWTACERALLNRDRKPVREPESAPAQAQGRTPSGGGARKRAPRTRAARQQAARARANAAARADRAAKPGEDGGRAATPGPAEPAEPADPAPGSSSAADQAVTTPR

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Crispr_ID: NZ_CP047146_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_4

1592190-1592290

Orphan

Consensus_repeat	Method
TCGCTGTAGCTGCTCTTGCGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP047146_4

>merge|NZ_CP047146|4|1592190-1592290|CRISPRCasFinder
TCGCTGTAGCTGCTCTTGCGCCAGTTGACGGCGCCAGGGAAGTCGTGAGCGACCTCGACGCAGTTGCCGCCCTTGTCATCGCTGTAGCTGCTCTTGCGCCA

>NZ_CP047146|4|4|1592190-1592290|CRISPRCasFinder
TCGCTGTAGCTGCTCTTGCGCCA	GTTGACGGCGCCAGGGAAGTCGTGAGCGACCTCGACGCAGTTGCCGCCCTTGTCA
TCGCTGTAGCTGCTCTTGCGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159503854.1\|1597635_1598598_-\|zinc-ABC-transporter-solute-binding-protein	unknown	unknown	gnl\|CDD\|376518
NZ_CP047146.1\|WP_159503838.1\|1581873_1582140_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159503844.1\|1589534_1589897_-\|DUF742-domain-containing-protein	unknown	unknown	gnl\|CDD\|283084
NZ_CP047146.1\|WP_159503852.1\|1595263_1595689_-\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|133478
NZ_CP047146.1\|WP_159509792.1\|1585568_1586279_+\|TerB-family-tellurite-resistance-protein	unknown	unknown	gnl\|CDD\|377455
NZ_CP047146.1\|WP_159503849.1\|1593252_1593468_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159503840.1\|1583602_1585360_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_CP047146.1\|WP_159503850.1\|1593520_1594267_+\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|234622
NZ_CP047146.1\|WP_159503845.1\|1589893_1590322_-\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|367422
NZ_CP047146.1\|WP_159503855.1\|1598810_1600193_+\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NZ_CP047146.1\|WP_159503843.1\|1588933_1589512_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|225138
NZ_CP047146.1\|WP_159503839.1\|1582224_1583310_-\|peptidase-M4-family-protein	unknown	unknown	gnl\|CDD\|341060
NZ_CP047146.1\|WP_159503846.1\|1590318_1591800_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340391
NZ_CP047146.1\|WP_159503848.1\|1592301_1593135_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP047146.1\|WP_159509793.1\|1596755_1597526_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224046
NZ_CP047146.1\|WP_159503856.1\|1600494_1601076_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380062
NZ_CP047146.1\|WP_159503842.1\|1587506_1588937_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP047146.1\|WP_159503851.1\|1594322_1595141_+\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|237826
NZ_CP047146.1\|WP_159503853.1\|1595862_1596756_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|224033
NZ_CP047146.1\|WP_159503841.1\|1586355_1587591_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159503854.1\|1597635_1598598_-\|zinc-ABC-transporter-solute-binding-protein	gnl\|CDD\|376518	pfam01297, ZnuA, Zinc-uptake complex component A periplasmic. ZnuA includes periplasmic solute binding proteins such as TroA that interacts with an ATP-binding cassette transport system in Treponema pallidum. ZnuA is part of the bacterial zinc-uptake complex ZnuABC, whose components are the following families, ZinT, pfam09223, pfam00950, pfam00005, all of which are regulated by the transcription-regulator family FUR, pfam01475. ZinT acts as a Zn2+-buffering protein that delivers Zn2+ to ZnuA (TroA), a high-affinity zinc-uptake protein. In Gram-negative bacteria the ZnuABC transporter system ensures an adequate import of zinc in Zn2+-poor environments, such as those encountered by pathogens within the infected host.	1.49033e-91
NZ_CP047146.1\|WP_159503850.1\|1593520_1594267_+\|DNA-repair-protein-RecO	gnl\|CDD\|234622	PRK00085, recO, DNA repair protein RecO; Reviewed.	4.57991e-85
NZ_CP047146.1\|WP_159503852.1\|1595263_1595689_-\|transcriptional-repressor	gnl\|CDD\|133478	cd07153, Fur_like, Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators. Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.	2.22461e-41
NZ_CP047146.1\|WP_159509792.1\|1585568_1586279_+\|TerB-family-tellurite-resistance-protein	gnl\|CDD\|377455	pfam05099, TerB, Tellurite resistance protein TerB. This family contains the TerB tellurite resistance proteins from a a number of bacteria.	0.000143411
NZ_CP047146.1\|WP_159503856.1\|1600494_1601076_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380062	pfam17935, TetR_C_27, Tetracyclin repressor-like, C-terminal domain. This is the C-terminal domain present in putative TetR transcriptional regulators.	1.45373e-46
NZ_CP047146.1\|WP_159503840.1\|1583602_1585360_+\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_CP047146.1\|WP_159503844.1\|1589534_1589897_-\|DUF742-domain-containing-protein	gnl\|CDD\|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	3.69218e-20
NZ_CP047146.1\|WP_159503845.1\|1589893_1590322_-\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	1.76403e-14
NZ_CP047146.1\|WP_159503855.1\|1598810_1600193_+\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NZ_CP047146.1\|WP_159503843.1\|1588933_1589512_-\|ATP-binding-protein	gnl\|CDD\|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	6.03499e-37
NZ_CP047146.1\|WP_159503839.1\|1582224_1583310_-\|peptidase-M4-family-protein	gnl\|CDD\|341060	cd09597, M4_TLP, Peptidase M4 family including thermolysin, protealysin, aureolysin, and neutral protease. This peptidase M4 family includes several endopeptidases such as thermolysin (EC 3.4.24.27), aureolysin (the extracellular metalloproteinase from Staphylococcus aureus), neutral protease from Bacillus cereus, protealysin, and bacillolysin (EC 3.4.24.28). Typically, the M4 peptidases consist of a presequence (signal sequence), a propeptide sequence, and a peptidase unit. The presequence is cleaved off during export while the propeptide has inhibitory and chaperone functions and facilitates folding. The propeptide remains attached until the peptidase is secreted and can be safely activated. All peptidases in this family bind a single catalytic zinc ion which is tetrahedrally co-ordinated by three amino acid ligands and a water molecule that forms the nucleophile on activation during catalysis. The active site is found between two sub-domains; the N-terminal domain contains the HEXXH zinc-binding motif while the helical C-terminal domain, which is unique for the family, carries the third zinc ligand. These peptidases are secreted eubacterial endopeptidases from Gram-positive or Gram-negative sources that degrade extracellular proteins and peptides for bacterial nutrition. They are selectively inhibited by Steptomyces metalloproteinase inhibitor (SMPI) as well as by phosphoramidon from Streptomyces tanashiensis. A large number of these enzymes are implicated as key factors in the pathogenesis of various diseases, including gastritis, peptic ulcer, gastric carcinoma, cholera and several types of bacterial infections, and are therefore important drug targets. Some enzymes of the family can function at extremes of temperatures, while some function in organic solvents, thus rendering them novel targets for biotechnological applications. Thermolysin is widely used as a nonspecific protease to obtain fragments for peptide sequencing. It has also been used in production of the artificial sweetener aspartame.	8.66562e-121
NZ_CP047146.1\|WP_159503846.1\|1590318_1591800_-\|sensor-histidine-kinase	gnl\|CDD\|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	5.18268e-14
NZ_CP047146.1\|WP_159503848.1\|1592301_1593135_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.81764e-09
NZ_CP047146.1\|WP_159509793.1\|1596755_1597526_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	3.46435e-74
NZ_CP047146.1\|WP_159503842.1\|1587506_1588937_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	5.57788e-37
NZ_CP047146.1\|WP_159503851.1\|1594322_1595141_+\|isoprenyl-transferase	gnl\|CDD\|237826	PRK14829, PRK14829, undecaprenyl pyrophosphate synthase; Provisional.	2.20177e-141
NZ_CP047146.1\|WP_159503853.1\|1595862_1596756_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	4.21099e-60
NZ_CP047146.1\|WP_159503841.1\|1586355_1587591_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.77437e-83

>NZ_CP047146.1|WP_159503846.1|1590318_1591800_-|sensor-histidine-kinase
MTSIPEALLWCLSAGTAAAVVLAALSIRASGQRKALRARLAAAEEHSSATLHSNTELSARLRATEAEIRHLAGARLPDLTMALAHPHVPVRGLLDGRFAGSETDEALSGVLEQVGEAITKERQRVDAAAQSTLRGATTTIQALLYRLQTALQDMQHKYDDPQIAQDLLDADFLNEQALRRVQATGVVCGAWPGLTREDSYLAELVVGATSRLRGYERVQISNQLRDPVAVVARAVEPIAITVTELLANALHHSHRELPVTVTLQQGNRGASVIIDDYGVGMHDDEIKHAMELLAGDDSLLLTQLGDPPRSGFAAAGQLVRQYGFGVHVEPSPYGGVRAVVYIQGDPLLTVLDEAAQPMSVMAPMPRASAAGTGAGVRDRSSSAASVLPTGAAAPASAAGVTGGTGDIGAAARPATAPSAPSAEVPQADGGLPRRRRRKPLSEEQADPHDDSTINLRSPEETASRWAALQQGTESGRAAAQSDPPRRPEGNTES
>NZ_CP047146.1|WP_159503845.1|1589893_1590322_-|roadblock/LC7-domain-containing-protein
MNSPTRRRVAEDKSWVLAPLLELPHVVHAAVISGDGFIEGASPGLSREAAEGVAAMMSALQGAGRAVTAAFAEKTDTRLRQTVIESEEGFVFAIPAGENTCLAVFAGPEVNMGVVAHHMQIQVTTLGSKVMNSRARDTGTPA
>NZ_CP047146.1|WP_159503844.1|1589534_1589897_-|DUF742-domain-containing-protein
MTPRQSGGRRLVPAYLATGGRAQPSRNTLDRLTVLHGVDMPITSEVRPEEHRILELLQPGALTLAEVAAHLHLPVSVVKVLVADLVDAGRLHARVPIPEAEQFDRQILERVLDGLRSLKS
>NZ_CP047146.1|WP_159503843.1|1588933_1589512_-|ATP-binding-protein
MYLDGDRQTLVKLLVAGPFGVGKTTLIRALSEIQPLHTEEVMTQSGAMVDDLAGVRDKTTTTVAIDFGRLTLPGDLVLYLFGTPGQKRFRPLWQDIARGALGALVLADTRRLADSFEVMDIVEEAGLRYAVAVNTFPDAPQYDVEKLRDALDLHPDTPLVLCDARDKEQSVDALIALVRHVLDNLPEENPNP
>NZ_CP047146.1|WP_159503842.1|1587506_1588937_-|cytochrome-P450
MTSPYQPGAAPSPSCPAQAVPPPQEQAPPPGCPAHGAPQHQAPAQPDAHAPVKLYGPDFAADPHRFYRHLRQYGALAPVEIAPDVTAMLVTDYRAALDLLNDDATWSKDSREWMTTVPQDTPVMPMLMWRPNVFYSDGPAHVRYRDVIVDSFKLVEPHELRARVQHAADTLIQRFGARGEADLIADYARLIPLLMFNSLFGLPDSYSERLIAAIGGMLEGNSPEEAAAANEAFTTYIMELVGAKKGARGPDLTSWFMDHPNALNDEELIHQIILVMGAGNEPLANLIGNALSRMLSDDRYYNTLSGGALTVHDAINEVLWNDPPLTNYSAHFPVRDVFFHGTWVRAGQLVMVSYAAANSQFDTTEVLAPGSGSGSHLSWAAGPHACPVKRHALLIATTAIERLTAWLSDIELAVDHSELEWRNGAFHRALAALPARFTPITPDQAGATPWHNSEQSAMSSTRPAPTSTARQPASAN
>NZ_CP047146.1|WP_159503841.1|1586355_1587591_-|cytochrome-P450
MAQQRAERYVIDPAGTDIHGEAARLRELGPAARIELPGSIPAWAITGHGLLKELLTDDRVSKDPRAHWPEWQREEIRGSWLQSWIGVTNMFTAYGADHRRLRKLIAPAFTARRTDAMVPRVEQVTRALLDGLAARPAGEVVDLRESFNHPLPMQVICELFGYPEGRPRVELARIVAEIMDTTATPEQASATWVSVDALLGDLVAAKRAQPADDLTSLLVAARDDEGQGMTERELLDTLILVIGAGHETTVDLLGNAVYALLTHPEQLRLVLDGTVSWNDVIEETLRWSPSIASLPLRFAVADIELPHGEVIRKGEALLPMYAAAGRDAAQHGPDAAAFDVRRTSQEHLAFGHGVHHCIGAPLARLEARTALPALFDRFPDMRLAVEPGELAPAGGFIAGGLRSLPVRLTAG
>NZ_CP047146.1|WP_159509792.1|1585568_1586279_+|TerB-family-tellurite-resistance-protein
MRNLGVTGVRTSWRTVADGEFFCPDCGGDRNYLRRTGRRRLTLLGVPVLSRGTAGPVLECSACQGHFGPDALDHPTTVRFSAMLRDAVHTLTLALLAAGGTSSRTVRDTAVDTVRAAGFDDCSEDQLLTLLAALAADSGRLTGTYDAVTGGHCGAQGLDPCGTALAIELHEALEPLAPHLAPAGRESLLLQGARIALADGSYTPAEREVLGTVGAALTLRPADVHRLLAAAARTPR
>NZ_CP047146.1|WP_159503840.1|1583602_1585360_+|2-isopropylmalate-synthase
MSQPVGRPTPITNATRTQQPSGMPIHKYRPYEAVDIPDRTWPDGRITQAPRWLSTDLRDGNQALIDPMSPARKREMFDLLVRMGYKEIEVGFPSSGETDFAFVRSIIEEGAIPEDVTISVLTQAREELIERTVESLVGARRATVHLYNATAPTFRRVVFRGSKEQVKQIAVDGTRLVMEYADKLLGDETAFGYQYSPEIFTDTELDFALEVCEGVMDVWQPEEGREIILNLPATVERSTPSTHADRFEWMSRNLSRREHVCLSVHPHNDRGTAVAAAELAIMAGADRIEGCLFGQGERTGNVDLVTLGMNLFSQGVDPQIDFSQIDEIRRTSEYCNQMEVHPRHPYAGDLVYTAFSGSHQDAIKKGFDAMEADAAAQGRTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRRMQIEFSRIIQEKTDAEGGEVTPAAIWSVFQDEYLPNPHDPWGRIQVKTGQTTTDKDGVDTLTVEAEVDGAETVLVGSGNGPISAFFHALQGIGVDARLLDYQEHTMSEGASAQAASYIECAIDGRVLWGIGIDANTTRASLKAVVSAVNRAGR
>NZ_CP047146.1|WP_159503839.1|1582224_1583310_-|peptidase-M4-family-protein
MDHNVTRKRTAPTTPVFCTIVPPHILGNLADSDDPELHGPARSTLEHDARHRTRRTDLAGRAAAPKEARAAADQPHRTIYDAGHEQNLPGTEVHAESDGPSKDASVNRAQSGLGATFAFYLKAYGRKSIDGKGLPLDATVHYGVKYDNAFWDGERMVFGDGDGRLFRDFTIPVDVIGHELTHGVTQYTAALDYQGQSGALNESISDVFGSLIKQYALGQTADQADWLIGADLLAPGVHGKALRSMKAPGTAYDDPQLGKDPQPATMAGYVTTTDDNGGVHLNSGIPNHAFYIAASTLGGKAWERAGQVWYDVLTGGHLAKNAQFADFAALTVQAAQARYGAGAEHDAMVKAWSEVGVTGKK
>NZ_CP047146.1|WP_159503838.1|1581873_1582140_-|hypothetical-protein
MRIHIRRTGGFAGIERRAEVDTDGRPDAADWQALAHRAVADAHPVPPPGVPDGFRYEITVDGKTVHCADPHLTEDQRELITRLLNEGA
>NZ_CP047146.1|WP_159503848.1|1592301_1593135_-|helix-turn-helix-domain-containing-protein
MANGSRMAAWEHWGAELKHRRELAGLTQNELGRRVFVSGGYIGQFEQAIRRPQLDVAIRIDEVLQTDGFFERAWRKLIDDKRYPDYFAAVAELERLATRICDCEPMIVPGLLQTPAYAHALILAGNPFAADEYIEEKVRTRLDRAVILKDASRPQYWAVLHEAVLRVPVGGPTVMAEQLDYIAQVARARKILVQVVPFAASAYPLMGKMLTLMEFEDAPPTAYTEGLYSGNLLDDPAIVKRAQQGYDLLRAAALSPEASLALIESVAEDYRQCASTT
>NZ_CP047146.1|WP_159503849.1|1593252_1593468_+|hypothetical-protein
MQQHLKEVDAVTTELREALARAGVVLPSLRPDPVSIAHRYMPPLVELGRCSMEVARQLTDALAERSRGERP
>NZ_CP047146.1|WP_159503850.1|1593520_1594267_+|DNA-repair-protein-RecO
MSLFRDDGIVLRTQKLGEADRIITLLTRGNGRVRAVARGVRRTKSKFGARLEPFSHVDVQFYARGGELVGRGLPLCTQSETIAAYGGGIVTDYARYTAGTAMLETAERFTDHEGEPAVQQYLLLVGALRTLANGEHAPHLVLDAFLLRSLAVNGYAPSFGACARCGLPGPNRFFSVAAGGVVCGDCRVPGSVVPSSEAIGLLGALLTGDWEAADACEARHVREGSGLVAAYLHWHLERGLRSLRYVEK
>NZ_CP047146.1|WP_159503851.1|1594322_1595141_+|isoprenyl-transferase
MAVRGILGRNRREYETPEPHPSGARPPKIPGELVPNHVAIVMDGNGRWAKERGLPRTEGHKVGEGVVLDVLKGCIEMGVKNLSLYAFSTENWKRSPDEVRFLMNFNRDVIRRRRDEMDALGIRIRWVGRMPKLWKSVVQELQIAQEQTKKNDAMTLYFCVNYGGRAEIADAAAAIAADVRAGKLDPSKVNEKTVAKYMYYPDMPDVDLFVRPSGEQRTSNYLIWQSAYAEMVFQDILWPDFDRRNLWDACLEYAKRDRRFGAAPIAEGESAT
>NZ_CP047146.1|WP_159503852.1|1595263_1595689_-|transcriptional-repressor
MATSAGSPVRGRSTRQRTAVSAALDEVDEFRSAQELHDMLKHRGDSVGLTTVYRTLQSLADAGEVDVLRTSEGEAVYRRCSTDDHHHHLVCRACGKAVEVEGPAVEKWADQIAAEHGFRDVAHTIEIFGTCGECADRAAAQ
>NZ_CP047146.1|WP_159503853.1|1595862_1596756_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MEILDYAFMQRALIAALIVGVTAPAIGIYLVQRRQALMGDGIGHVALTGVGLGFLLNSSPVWMATAVAVLGSVIMELIRWYGRTRGDLALAMLFYGGMAGGVLLMNLSDAGSNANLGTYLFGSITTVSPQDMTTICVLAALVLAITVGLRRQLFAVCLDEEFARVTGLPVRLLNLLVAVTAAVTVTVAMRVVGLLLVSALMVIPVAAAQQLSRSFAVTFAAAVAIGVVVTVAGTTTSYYVDVPSGATIVLFAIGLFVAFTALAAPLARKRARAAARAAEGCTLEVPAGRVPADDVRV
>NZ_CP047146.1|WP_159509793.1|1596755_1597526_-|ATP-binding-cassette-domain-containing-protein
MEGEPVIALRGATASLGARPVLRGVDLTVRPGEVVALLGANGSGKSTAVRSVIGQVPLTGGELSLFGTPFRRFGDWARIGYVPQRTTAAGGVPATVREVVTAGRLARTKLGILRRADRAAVHRALELVGMADRARDSVNALSGGQHQRVLIARALAGEPDLLIMDEPMAGVDLASQEVLAAALREQVARGTTVLLVLHELGPLEPLIDRAVVLRDGCVVHDGPPPQAVGQHALPGHDHVHPHADASAEPLRTGLLS
>NZ_CP047146.1|WP_159503854.1|1597635_1598598_-|zinc-ABC-transporter-solute-binding-protein
MNVRPNISTAAIAGAAVLGLLSLTACSAAGTGRSGDGKLKVTASFYPMQFLAEQIGGSHVEVSNLTKPGVEPHDLELTPKQTAQLGESGAIVYLKGLQPAVDDAIKQSGVKNVADAASLTSLETHGTEVDGHHHSTGDNHSHSESEPGRDPHVWLDPVKYAEVAKGVGRTLAQADPKNRADYQKNTDALVKKLDGLDKEFRDGLKNRASDTFITTHAAFGYLAERYGLTEEAISGLDPESEPSANRIKDLHTLAAQHHVSTVFFETIANPATAEALAGDLHLKTDVLDPLEGITPKSRGKDYFGIQRANLAALEQALGGK
>NZ_CP047146.1|WP_159503855.1|1598810_1600193_+|glycine--tRNA-ligase
MAADKIDTIVSLSKRRGFVYPCSEIYGGSRAAWDYGPLGVELKENLKRQWWRAMVTSREDVVGIDSSVILAPEVWQASGHVATFTDPLTECTSCHKRFRADHLEEAYEEKHGRLPENGLADINCPHCGNKGGFTEPKQFSGLLSTHLGPSQDTASVAYLRPETAQGIFTNFAQVQQTSRKKPPFGIAQMGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEQWHEYWMEQRWNWYRDLGIREENIRWYEHPAEKLSHYSKRTADIEYRFQFGGSEWGELEGVANRTDYDLSSHSKASGQDLSYFDQEAGERWTPYVIEPAAGVGRAMLAFLLDAYVEDEAPNAKGKMEKRTVMRLDPRLAPVKAAVLPLSRNPQLSPKAKGLAADLRKNWNIEFDDAGAIGRRYRRQDEIGTPFCVTVDFDTLDDNAVTVRERDTMKQERVSLDQIQSYLGGRLLGC
>NZ_CP047146.1|WP_159503856.1|1600494_1601076_-|TetR-family-transcriptional-regulator
MPPETLTPERILEATEEVLRRYGPAKATVVDVARALGVSHGSVYRHFRTKTALREAVTARWLDRTSEQLATIVRDEGPADDRLRRWLATLFEAKRHKAGDDPELFATYMTLIGESGGVVDRHVTDLESQLATIIEAGVAEGAFRAPSPTTTAHAVFAATGRFHDPCYAAEWSRPEITADFEAVRDLVMRGLQG

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Crispr_ID: NZ_CP047146_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_5

1665068-1665175

Orphan

Consensus_repeat	Method
GGTTACTGGTTCGAGTCCAGTCGGGGGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP047146_5

>merge|NZ_CP047146|5|1665068-1665175|CRISPRCasFinder
GGTTACTGGTTCGAGTCCAGTCGGGGGAGCTCGGTCCCCTGTAGCTCAATTGGCAGAGCATTCGGCTGTTAACCGGAGGGTTACTGGTTCGAGTCCAGTCGGGGGAGC

>NZ_CP047146|5|5|1665068-1665175|CRISPRCasFinder
GGTTACTGGTTCGAGTCCAGTCGGGGGAGC	TCGGTCCCCTGTAGCTCAATTGGCAGAGCATTCGGCTGTTAACCGGAG
GGTTACTGGTTCGAGTCCAGTCGGGGGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159503897.1\|1662957_1664427_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|198375
NZ_CP047146.1\|WP_159509803.1\|1673685_1674453_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NZ_CP047146.1\|WP_159503891.1\|1652164_1653175_+\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
NZ_CP047146.1\|WP_159503905.1\|1674540_1675653_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|223609
NZ_CP047146.1\|WP_159509802.1\|1672690_1673566_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP047146.1\|WP_159503902.1\|1669145_1669880_-\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NZ_CP047146.1\|WP_159503898.1\|1664505_1664805_-\|YtxH-domain-containing-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159503890.1\|1651605_1652067_+\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|377602
NZ_CP047146.1\|WP_159503903.1\|1669885_1671049_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|224747
NZ_CP047146.1\|WP_159503894.1\|1658106_1659369_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NZ_CP047146.1\|WP_159503899.1\|1665988_1666753_-\|N-acetyltransferase	unknown	unknown	unknown
NZ_CP047146.1\|WP_159509801.1\|1655584_1656514_+\|sirohydrochlorin-chelatase	unknown	unknown	gnl\|CDD\|225049
NZ_CP047146.1\|WP_159503900.1\|1666749_1667610_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NZ_CP047146.1\|WP_159503895.1\|1659641_1661558_+\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NZ_CP047146.1\|WP_159503906.1\|1675830_1676835_-\|galactokinase	unknown	unknown	gnl\|CDD\|224493
NZ_CP047146.1\|WP_159503892.1\|1653224_1655420_-\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239155
NZ_CP047146.1\|WP_159503896.1\|1661676_1662924_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NZ_CP047146.1\|WP_159503893.1\|1656510_1657911_+\|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl\|CDD\|235098
NZ_CP047146.1\|WP_159503901.1\|1667734_1669162_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159503904.1\|1671347_1672631_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270450

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159503897.1\|1662957_1664427_-\|sugar-kinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	2.20034e-118
NZ_CP047146.1\|WP_159509803.1\|1673685_1674453_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	9.26166e-80
NZ_CP047146.1\|WP_159503891.1\|1652164_1653175_+\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	3.55094e-155
NZ_CP047146.1\|WP_159503905.1\|1674540_1675653_+\|radical-SAM-protein	gnl\|CDD\|223609	COG0535, COG0535, Predicted Fe-S oxidoreductases [General function prediction only].	9.73972e-18
NZ_CP047146.1\|WP_159503902.1\|1669145_1669880_-\|HAD-IA-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	2.98298e-24
NZ_CP047146.1\|WP_159503890.1\|1651605_1652067_+\|gamma-glutamylcyclotransferase	gnl\|CDD\|377602	pfam06094, GGACT, Gamma-glutamyl cyclotransferase, AIG2-like. GGACT, gamma-glutamylamine cyclotransferase, is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline.	2.38334e-18
NZ_CP047146.1\|WP_159503903.1\|1669885_1671049_-\|serine/threonine-protein-kinase	gnl\|CDD\|224747	COG1834, COG1834, N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism].	3.15632e-20
NZ_CP047146.1\|WP_159503894.1\|1658106_1659369_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	6.46384e-68
NZ_CP047146.1\|WP_159509802.1\|1672690_1673566_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.07622e-57
NZ_CP047146.1\|WP_159509801.1\|1655584_1656514_+\|sirohydrochlorin-chelatase	gnl\|CDD\|225049	COG2138, COG2138, Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism].	1.31039e-23
NZ_CP047146.1\|WP_159503900.1\|1666749_1667610_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	4.61778e-27
NZ_CP047146.1\|WP_159503895.1\|1659641_1661558_+\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_CP047146.1\|WP_159503906.1\|1675830_1676835_-\|galactokinase	gnl\|CDD\|224493	COG1577, ERG12, Mevalonate kinase [Lipid metabolism].	7.35935e-19
NZ_CP047146.1\|WP_159503892.1\|1653224_1655420_-\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NZ_CP047146.1\|WP_159503896.1\|1661676_1662924_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	8.81446e-165
NZ_CP047146.1\|WP_159503893.1\|1656510_1657911_+\|deoxyguanosinetriphosphate-triphosphohydrolase	gnl\|CDD\|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NZ_CP047146.1\|WP_159503904.1\|1671347_1672631_+\|extracellular-solute-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	8.78787e-94

>NZ_CP047146.1|WP_159503898.1|1664505_1664805_-|YtxH-domain-containing-protein
MRYRLTFIAGLAVGYVLGTRAGRERYEQLRKGAQRIARNPAVRNTAESAALTGRQTATRVFGTVSAKVEGRLPAPVAERVRSLREQRANDEDDWGTSNT
>NZ_CP047146.1|WP_159503897.1|1662957_1664427_-|sugar-kinase
MGIVAGLDSSSESTRIVVCDADTGAVVRQGYAPHPVEKGPDVDPQAWLMSLGEAAGNGLLEGVQAIGVSAQQHGLVPLDADGNLVRPALVGNDKRAQGAAADLVDSLGGRSAWAQAVGSVPQAAHPVTKLRWLARAEPANAARIAEVMQPHDWLAWQLLGRPARRTTDRGGASATGFWSAATGTYRPDLVELALGHQVRLPEVLGPSGTAGFTPEGLLISAGTGETMAAAFGLGVGAGDAVVSLGASGSVFGIHHEALVDPSGTITSFADATGRHLPVVHTTNAVRVLRGAAELLGTDLAGLSDLALKSSPGAYGMVLLPYLEGERTPHLPHTAGSLHGMRRESMKPEHLARAAVEGMLCGLADALDVLRGRGVAVHRVFLLGAAAELGAVQTAAPGLFGAQVVVPQPADYAALGAARQAAWAWNAAHRTGTPAAGGDGGSGYPEPPQWPAAASQVFEPGEELPVWQAVRQQYAAVRDEAHPGAFQREG
>NZ_CP047146.1|WP_159503896.1|1661676_1662924_+|sigma-70-family-RNA-polymerase-sigma-factor
MPESSERGTPGRTHPGTGREYAAQPFVTYGTDGGSAATVPGLSAAPDAITLEVAPVQTQTLPDAPPAGTPAAPALADLPTGQVTVPQQPEPPAAEMVLEEITPEPPPRPGTVSPSSDLFRQYLREIGRIPLLTAAEEVELARRVEAGLFAEEKLTGTPDLDSQLAYDLDKLVVLGRMAKRRLIEANLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQEHGCEPTPEEVAASLDLTEERVSEVLRLAQEPVSLHAPVGEEEDVALGDLIEDGDAASPVESAAFLLLREHLDAVLSTLGERERKVVQLRYGLADGRPRTLEEIGRIFGVTRERIRQIESKTLNKLRDHAFADQLRGYLD
>NZ_CP047146.1|WP_159503895.1|1659641_1661558_+|DNA-primase
MAGRINDDDVKAVRDAVPIDAVVSEYLQLRNAGGGNLKGLCPFHDEKSPSFHVSPAKGLYHCFGCQEGGDTVDFVMKIDHLSFAETIERLASQAGITLRYEEGGYTPGRQQGERTRLVEAHKAAAQFYGEQLDSPEAEIARKFLAERGFDQAAAQHFGVGYSPAGWDHLTRFLRGRGFSDQELVLSGISQEGRRGPIDRFRGRLMWPIRDIAGEVVGFGARKLREDDNGPKYLNTPETPIYRKSQVLYGIDLAKKEIAKTSRAVVVEGYTDVMACHLAGITTAIATCGTAFGEGHIKILRRLLMDNSGSEVVFTFDGDAAGQKAALRAFEDDQKFAAETSIAITPGGMDPCDLRLAKGDQAVADLVESRTPLFEFALRHVVSRHNLDTTVGRAAALDEAAPIVANIKNSSIQHESAVQLAGMLGILDTQFVVRRVGQLARWARERGRDGGPGQGRPQRPGTAPAAAPQRPAPGTGGPALNLRSPAHRVERELLKLALQRPDLVSPAFDAYGADEFTAPPYAVVRQCIEDAGGASAGAADSGYVPRVREAAPDDTVRAMVTELAVEPLHTRREPDEAYAGVQLVAVRLAAVNQRVTEIRGTLQRLGPRADPEHLAAVQNELWVLQQYGQALRERGYGAL
>NZ_CP047146.1|WP_159503894.1|1658106_1659369_+|FAD-dependent-oxidoreductase
MVDAHQTFVIVGGGLAGAKAAETLRTEGFTGRVILICDERDHPYERPPLSKGYLLGKDERDSVFIHEPAFYAQADIELHLGQPAVHLDPAAKTVRLGDGTLIAYDKLLLATGAEPRRLDIPGTGLAGVHHLRRLAHAERLRGVLASLGRDNGHLVIAGAGWIGLEVAAAARSYGAEVTIVAPHPTPLHGILGPELGALFADLHRDHGVRFHFGARLTEIVGHDGMVLAVRTDDGEEHPAHDVLAAIGAAPRTALAEQAGLDVVDRADGGGIAVDAALRTSDPYIYAAGDVAAADHPLLDTRLRVEHWANALNGGPAAARAMLGQDVSYDRIPYFFSDQYDVGMEYSGYAPPGSYDQVVCRGDVGKREFIAFWLSEGRLLAGMNVNVWDVTGTVQQLIRSGAELDPDKLQDPSVPLESLLP
>NZ_CP047146.1|WP_159503893.1|1656510_1657911_+|deoxyguanosinetriphosphate-triphosphohydrolase
MTGTSPATPPPPEAGPAPHTTPHSATPGYTAADTERWVPEPDKRPGRTAFQRDRARVLHSAALRRLAGKTQVVTPGTHTHAWDASPRTRLTHSLECAQVGRELGAALGCDPDLVETACLAHDLGHPPFGHNGEQALNEVAAPCGGFEGNAQSLRLLARLEPKRFVPAADGHPVSVGLNLTRAALDAATKYPWPRGGHPEGPDSPKFGVYEDDLPVYAWFRAGAPPAARSFEAQVMDWSDDVAYSVHDVEDGLHAGHLDPNVLLADAERAEIFAVAAERYAPGAGEAELAAALDRLLDQEWWPHGYDGTALAQARLKDATSQLIGRFCQAAEGATRERWGYPRSRPGSGGGTGRLTRYAAELVVPAETRLECAVLKAVADRYVIQRPDQEALRADQRVVIAELAEALLARAPDGLDPQFRSLFAAAADDTARMRAVIDQIAALTDASARSLHARLTRPPGNGWGNPG
>NZ_CP047146.1|WP_159509801.1|1655584_1656514_+|sirohydrochlorin-chelatase
MAPTPHHPVPDPYDPATPPAAPVGAAELASAITDQLSSRLGTVRLHGYRRPTGTRPASEAAAPTLVAVAHGSRHPQAAPTVRALLARVRALRPGLPVRLGHIELDRPLLADTLAGLRGEVVLVPLLLARGHHVTHDLPAALAAADHLTGRIAAPLGPHPLLAEALHGRLLEAGLPARPRARSAVVLAAAGSRAPRSAEDTARTAELLSARLGGLPVLPAFASAAAPTVPEAIRTLTARGHDPRRIAVAACFTAPGRFADQCAAAAPGPAAAPLGDHTALARLVLHRYDQALSARTGSGTEGIRAATVAV
>NZ_CP047146.1|WP_159503892.1|1653224_1655420_-|molybdopterin-dependent-oxidoreductase
MDAATVETHCPYCALQCGMGLRPVGRPAGPAVEVVERTAFPVNRGALCGKGRTAPELLTPGARLSSPLVRDAATGELVPAGWDEALDRVADGLRRAGAAYGRDAVGVFGGGGLTNEKAYTLGKFARVVLGTSQIDYNGRFCMSSAAAAHGRAFGLDRGLPFPLADVARTGCVILVGSNLAETMPPALRYLTELKENGGRLIVVDPRRTRTAEQADLHLAPRPGTDLALALGLLHLVVAQGRTDEEFIAERTSGWPEARAAAMAHWPEMVERITGIPVPRLREAVRMFCEAPSSMVLTARGPEQQSKGTDTVGAWINLCLATGRAGRELSGYGCLTGQGNGQGGREHGQKADQLPGYRKLDDPAARRHVAQVWGVEAASLPGPGRSAYELLEALGGDIRALLLMGSNPVVSAPRAAHVEGRIRSLDFLAVADVVLSETAQLADVVLPVAQWAEETGTTTNLEGRVLLRRRAVAPPPGVRTDLEVLGGLAARLGHAKGFPSDPEEVFDELRRASAGGPADYSGITYERIAAEDGVFWPCPAGPESAGDGGPAADGAPGGGEPSVSSAADSAAAAPRFPHPGTPRLFLDRFATPDGRARFVPVAHRPAAEETDAAYPVVLTTGRVLAQYQSGAQTRRVAELNAAEPGPYVQLHPQLAERLGVADGEPVAVVSRRGRAVAPARVSGAIRPDTVFMPFHWAGEGRANSLTNPALDPVSRMPEFKVCAVRIERVQPA
>NZ_CP047146.1|WP_159503891.1|1652164_1653175_+|adenosine-deaminase
MPSNSPSAPAHRPLPKAELHLHIEGTLEPGLAFALAERNGVTLPYATEDDLRSAYSFTDLQSFLNLYYALMAVLRTEDDFADLADAYLARAKEQGVRHAEIFFDPQAHTARGVPIGTVVRGLSRALDAAPRNHGITTRLIMCFLRDESADSALETFEAARPYFDRITAVGLDSAEVGHPPSKFREVYELARQAGLKCVAHAGEEGPASYVWEALDVLGVDRIDHGVRSLEDERLVARLVADRVPLTVCPLSNVRLRVIDDLADHPLPAMLDAGLLVTVNSDDPAYFGGYADDNFTAVRDALGLDDATLRTLARNSFLASFLDDETRAAYLKELDAF
>NZ_CP047146.1|WP_159503890.1|1651605_1652067_+|gamma-glutamylcyclotransferase
MTIEDERLPFFVYGTLRPGEANHARFLRGRTAAEEPARIGGALLYEGPGYPYAVAGPADAVVHGALVWPRAADYEDVRTALDRLEGYIPGAEGSGRNLYERVATEAVRADGGTVRAWVYLVAGPQAARLRATGTPVAGGDWTGRRGHRAGNPG
>NZ_CP047146.1|WP_159503899.1|1665988_1666753_-|N-acetyltransferase
MTPAFVHHSERPELWDRVSDEFAGIVPEYNLHGDINAGFWDRLFSDFADHQFLLHDPDTDTVLGAGRTLPRTWDGTPEGLGTGLDASIEAAFRDHDAGAAPDALCALGIEIPRAHQGRGHSTRLLGHMADMARAAGLSHVVVPVRPTWKDRYPLVPIERYASWTRPDGAPFDPWIRTQVRQGGTIAAAVAQSSRITGTVAEWETWTGMAFPDDGTYVFPGGLDTLHIDHARDRGAYWEPCVWITHDVRRPAPAP
>NZ_CP047146.1|WP_159503900.1|1666749_1667610_-|methyltransferase-domain-containing-protein
MGSEFRVRELVLGIEGLALLRHAMDADEEFIAARLAEIRSYADDSAATRPDRRKPVSELDAADGYASWSSRYDSLPSAYLEVEEPILHGLLDRGPAGTALDAACGTGRQTAALAARGYRTIGVDQSPEMLAHAHRKAPGAEFREGHLEKLPLDDDSVDLAVCSLALTHLPDLSSGIGELARVVRPGGRVIVSDLHPFVTTLQGQCIFVHDNDRLAFVRNHRHLHSSYLSAFADAGLTVRECHEPVFNGRLAPGGYEESIADAARAAWEGIPLVVIWAAEKPETSAA
>NZ_CP047146.1|WP_159503901.1|1667734_1669162_+|hypothetical-protein
MSTDAGEFRVRFYRLGRELAFMAETGPYPGVPAAAPPHPDGVREHASPAVDWDWPPYDHRIPDDWPPGIYLAHFVEEEGRGEGEERRARDVALLDDTGIAGFGREFFVVRPRHPGAGGARILYKKSTYTRHAYNRADRADVQRAASLYDHPVYQEGGADRPRGHQLSLHRPGGVDDLAYWDAPFIAWLERSGYEVEYCTDLDLHEDPGLLAPYRLLLSVGHDEYWSAAMRAQVAEFVRGGGNVAFLSANTCWWRVHPVDGNSAFVSDTDHHVGTEYPHLPATDLWWPAPPDGVGEPENALTGVSFRNGGMWPGDWPGDRPREGYRVQHADHWVYEGTGLRDGTDGGAQDALGAGTALIGYECDGAAFATDADGVARATGADGTPESFLILGIYLLDPVHDDFHHLRWGHWNCPEREAAITSPRAATMGLYTAGGTVFTAGTTDWPVVCGRELDPGVVRVTRNVLNRLAGPATADR
>NZ_CP047146.1|WP_159503902.1|1669145_1669880_-|HAD-IA-family-hydrolase
MPDDRGDTARGGIRAVILDFYGTLVRLVEPLPPSHRSLFARRGLTEAAERWGDQWAVGPRDGEEHTAHSVSEQAYRAWEVDRLRRRARDCGVPEPVAGELAVELDRAMKDLRLALFDDVVDTLAELRARGVRVAVCSNWYWDLDRAIEDVGLAGLVDTAVTSARAGARKPHPLIYRAVLERCQVPAGQALFVGDMWEPDVAGPLACGMRAAHLWRADRVVEGVAPPLPDGAVRISSLAALSGLL
>NZ_CP047146.1|WP_159503903.1|1669885_1671049_-|serine/threonine-protein-kinase
MTEYGTTAADPATRPLKVNSWNGWDPLRHVVVGRADNTVVQAPEPAVRRDFPDDGFPLGTYGPMPADMTAEANEQLDNFAELLRRRGIRVDRPTPLDFSQQVSTPDWSQESMSGCMPPRDLLLTVGNEILEATMSYRSRWFEYLCYRPLLQRLFDADENMRWEAAPKPRLTDASYKPGFWDTYNTLGTEEQLARVRDYDLVLTEAEPLFDAADIARFGKDLFVQLSFVTNRGGYRWLKSHFPDFRVHAVTSTNTHPLHIDATWVPLRPGLVLHCGERLADAELMEFFRRNDWEVIEAVQPASWEHQPRLSYCSPWLAGNMLNLDPNTLCIEEKEVPLADQLSSYGFEIVPVPFRAVGPFGGGLHCATFDIERDGTLEDYFPHRHGRY
>NZ_CP047146.1|WP_159503904.1|1671347_1672631_+|extracellular-solute-binding-protein
MVGRVSRSAAALGALAVLGPAAGCGGPVAAGRSGDLTVWLTVDAQESWPDLVSEVNDRFRRTHPTAHVTVQYQQWTSKNQKLDAALSGRQVPDVVEMGNSETTNYVVNGAFAPVDPARFDHSGEWLGALRDACRNDGKTYCVPYYAGPRVGIYRTDLLHQVGVDHAPRSYPELRADLDKLKRKFGAADRNFSAFYMPGRYWYAAMAFVKDAGGEIAVRKDGRWQGSLSSAASVRGLAAWKDLLDAYYVGDRSKDNGDEPAVVGQGRVGMFYGTTWEARAATDSRSGGSPQLRGKFATFAFPGPSGGPLPPFLGGSTLAVPAKSAHRDLAQDWIRLFTDRTSQRRLIAADTLPNNTAQLREVAAGGIDGPAAQAAGRGWMTPLAPGWGAVEKSQVLQEMLQDIATGKRSVADAAQAADRRIDAVINEN
>NZ_CP047146.1|WP_159509802.1|1672690_1673566_+|ABC-transporter-permease-subunit
MPYLLIAPTVLALAAVLGYPLADLVLLSFQDMTRRELFSGTAPPWAGLAHYRSILTDGFFWTVLGRTVLFTVVCASATMVLSMLVALLMRRVARWVRTVMTGVLVAVWAMPVMVAASIFRWLSDADDGVVNWLLGQLPGLDFGKHNWFEDPWQGFAVITGVVVWGTVPFAAVTLHAALLQIPAEWEEAARVDGARGLRLFRHVTFPAVKPSAVLVTSLCAIWDFGVFNQIWLMRGGQPEKDYYLLGVYSFTESFAVNRYSAGAALAVLTVLMLLGGAVVYIRQLVHLGETE
>NZ_CP047146.1|WP_159509803.1|1673685_1674453_+|ABC-transporter-permease-subunit
MAFPIYWMLLTAFRPADEIHASPPRFWPDRLTLEHFHRALATPTFWANVRASVLIGAGTVAVSLLIGTLAAFALARFAFAGRKALVVVILGVQTIPSAGLIIPLYLLLSDAGLTDSLPGVILTYLVFLLPFTVWLLRGFVAAVPVELEEAAMTDGCTRLGAFRRVVLPLLAPGLVATSIYALVQAWNEYVLAYVLLSSNDKQPLSVWLVSFQTGFGTDYGGLMAGATLTALPVAVFFALVQRRISAGLATGAVKG
>NZ_CP047146.1|WP_159503905.1|1674540_1675653_+|radical-SAM-protein
MTFDRLDLVSKLYQPTGWPRILEAASGGPSSGPLVVDLDPTTFCDLACPECISGKLLNQGRFTPERLAELAGELVEMKVRAVVLIGGGEPLAHRGTRTVLRVLGEAGIAIGVVTNGTLIRQNLAELAAYASWVRVSVDAGTSDTYRLFRPDRKGRSVFDKVIGNMRLLAEAKAGALGYSFLVMTRQEPDGSVVSNHHEVLQAAELAHDIGCDYFETKAMFDDGHHVIQVPDGILASVEEQLAKARQWTGDGFEIVNSSTLTSLRNRVGPVQEKDYHRCPVAELRTLVTPSGVYVCSYHRGNAGARIGDAVTESLADIWRTSDRGIVDPSRDCRFHCARHRSNLELDKIRSGTAAGTLGVPEAGSEEDPFI
>NZ_CP047146.1|WP_159503906.1|1675830_1676835_-|galactokinase
MTMTRAVRGVPAGGAAVPCRACLSGEDLDWLGGRSVSLALDLTTSVTVRAPGARPPGGSGSGGGAGSWAEEVWAFLRRRLPGAGARPPAVTVRSDAPAASGLSSSTALIVALFRAFAGVAAPGAPLSARTLAQWAYEFEFGYFNGGGMDHLAVIAGGLLLLDGRTSGLPEIVGRVDFPDDWAVVVLDSATRKDTGDHIRSVRAQLAAGDARLAAYRERCDAASAAVWEAVRRRDPAALGGAMGEAHAAMRDLQGMSTPLLEELREVALRGAGLPLKLSGAGGGGALVGVCPAADAEEAAARLRRALGAAHPRARVLVTRAAAGLAPELAAAPAP

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Crispr_ID: NZ_CP047146_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_6

2422377-2422503

Orphan

Consensus_repeat	Method
GTCATGCGCGCAGCTCCTTCCCCGTGAGCTCCAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP047146_6

>merge|NZ_CP047146|6|2422377-2422503|CRISPRCasFinder
GTCATGCGCGCAGCTCCTTCCCCGTGAGCTCCAGGCTGTGCCGTCCCGGGGTGCGACCCCCGGACCCCCGGCCGAAAGGCGAGTGACCCCGCGTCATGCGCGCAGCTCCTTCCCCGTGAGCTCCAGG

>NZ_CP047146|6|6|2422377-2422503|CRISPRCasFinder
GTCATGCGCGCAGCTCCTTCCCCGTGAGCTCCAGG	CTGTGCCGTCCCGGGGTGCGACCCCCGGACCCCCGGCCGAAAGGCGAGTGACCCCGC
GTCATGCGCGCAGCTCCTTCCCCGTGAGCTCCAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159504455.1\|2430900_2431440_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225767
NZ_CP047146.1\|WP_159504451.1\|2428362_2429619_+\|SufS-family-cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_CP047146.1\|WP_159504447.1\|2423760_2424618_+\|ArsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP047146.1\|WP_159504439.1\|2412608_2414141_-\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|235579
NZ_CP047146.1\|WP_159504440.1\|2414147_2415266_-\|transaldolase	unknown	unknown	gnl\|CDD\|235117
NZ_CP047146.1\|WP_159504437.1\|2410768_2411551_-\|6-phosphogluconolactonase	unknown	unknown	gnl\|CDD\|273494
NZ_CP047146.1\|WP_016578643.1\|2427276_2427594_+\|non-heme-iron-oxygenase-ferredoxin-subunit	unknown	unknown	gnl\|CDD\|239604
NZ_CP047146.1\|WP_159504449.1\|2426095_2427280_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NZ_CP047146.1\|WP_159504454.1\|2430580_2430901_+\|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NZ_CP047146.1\|WP_159504442.1\|2417889_2418840_+\|protoheme-IX-farnesyltransferase	unknown	unknown	gnl\|CDD\|235293
NZ_CP047146.1\|WP_159504444.1\|2419421_2420480_+\|amidohydrolase	unknown	unknown	unknown
NZ_CP047146.1\|WP_159509879.1\|2409052_2410708_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234679
NZ_CP047146.1\|WP_159504452.1\|2429638_2430097_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918
NZ_CP047146.1\|WP_159504438.1\|2411547_2412612_-\|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA	unknown	unknown	gnl\|CDD\|213538
NZ_CP047146.1\|WP_159504441.1\|2415300_2417403_-\|transketolase	unknown	unknown	gnl\|CDD\|223100
NZ_CP047146.1\|WP_159504443.1\|2418899_2419286_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159504448.1\|2424614_2426036_+\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_CP047146.1\|WP_159504453.1\|2430093_2430435_+\|DUF59-domain-containing-protein	unknown	unknown	gnl\|CDD\|225062
NZ_CP047146.1\|WP_159504445.1\|2420480_2421461_-\|heme-A-synthase	unknown	unknown	gnl\|CDD\|224528
NZ_CP047146.1\|WP_159504450.1\|2427601_2428366_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159504455.1\|2430900_2431440_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|225767	COG3226, COG3226, Uncharacterized protein conserved in bacteria [Function unknown].	2.7224e-21
NZ_CP047146.1\|WP_159504451.1\|2428362_2429619_+\|SufS-family-cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP047146.1\|WP_159504447.1\|2423760_2424618_+\|ArsR-family-transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	8.57411e-49
NZ_CP047146.1\|WP_159504439.1\|2412608_2414141_-\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0
NZ_CP047146.1\|WP_159504440.1\|2414147_2415266_-\|transaldolase	gnl\|CDD\|235117	PRK03343, PRK03343, transaldolase; Validated.	0
NZ_CP047146.1\|WP_159504437.1\|2410768_2411551_-\|6-phosphogluconolactonase	gnl\|CDD\|273494	TIGR01198, 6-phosphogluconolactonase_6PGL., 6-phosphogluconolactonase. This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway].	1.28007e-84
NZ_CP047146.1\|WP_016578643.1\|2427276_2427594_+\|non-heme-iron-oxygenase-ferredoxin-subunit	gnl\|CDD\|239604	cd03528, Rieske_RO_ferredoxin, Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable microorganisms to tolerate and even exclusively utilize aromatic compounds for growth. ROs consist of two or three components: reductase, oxygenase, and ferredoxin (in some cases) components. The ferredoxin component contains either a plant-type or Rieske-type [2Fe-2S] cluster. The Rieske ferredoxin component in this family carries an electron from the RO reductase component to the terminal RO oxygenase component. BPDO degrades biphenyls and polychlorinated biphenyls. BPDO ferredoxin (BphF) has structural features consistent with a minimal and perhaps archetypical Rieske protein in that the insertions that give other Rieske proteins unique structural features are missing. CARDO catalyzes dihydroxylation at the C1 and C9a positions of carbazole. Rieske ferredoxins are found as subunits of membrane oxidase complexes, cis-dihydrodiol-forming aromatic dioxygenases, bacterial assimilatory nitrite reductases, and arsenite oxidase. Rieske ferredoxins are also found as soluble electron carriers in bacterial dioxygenase and monooxygenase complexes.	7.93891e-52
NZ_CP047146.1\|WP_159504449.1\|2426095_2427280_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	2.95157e-83
NZ_CP047146.1\|WP_159504454.1\|2430580_2430901_+\|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	6.84597e-28
NZ_CP047146.1\|WP_159504442.1\|2417889_2418840_+\|protoheme-IX-farnesyltransferase	gnl\|CDD\|235293	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional.	1.11183e-139
NZ_CP047146.1\|WP_159509879.1\|2409052_2410708_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NZ_CP047146.1\|WP_159504452.1\|2429638_2430097_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.18471e-60
NZ_CP047146.1\|WP_159504438.1\|2411547_2412612_-\|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA	gnl\|CDD\|213538	TIGR00534, Putative_OxPP_cycle_protein_OpcA, glucose-6-phosphate dehydrogenase assembly protein OpcA. The opcA gene is found immediately downstream of zwf, the glucose-6-phosphate dehydrogenase (G6PDH) gene, in a number of species, including Mycobacterium tuberculosis, Streptomyces coelicolor, Nostoc punctiforme, and Synechococcus sp. PCC 7942. In the latter, disruption of opcA was shown to block assembly of G6PDH into active oligomeric forms. [Protein fate, Protein folding and stabilization].	1.5385e-99
NZ_CP047146.1\|WP_159504441.1\|2415300_2417403_-\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NZ_CP047146.1\|WP_159504448.1\|2424614_2426036_+\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP047146.1\|WP_159504453.1\|2430093_2430435_+\|DUF59-domain-containing-protein	gnl\|CDD\|225062	COG2151, PaaD, Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only].	3.68424e-32
NZ_CP047146.1\|WP_159504445.1\|2420480_2421461_-\|heme-A-synthase	gnl\|CDD\|224528	COG1612, CtaA, Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones].	1.4905e-27
NZ_CP047146.1\|WP_159504450.1\|2427601_2428366_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	3.08943e-143

>NZ_CP047146.1|WP_159504445.1|2420480_2421461_-|heme-A-synthase
MPNTLNPLELIARRWQPSARFVRRAALATVVMAVVIVVTGGAVRLSDSGLGCSTWPQCTPGSLTPTAAMGVHGLIEFGNRMLTYVLCAVVGVFIIAARAQQPRRRSLTKLGWAQFWIILANAPVGGITVLTGLNPYIVAAHFLLSTALLTVAVLSWQRACEGDEEPRDLVARPVRQLAWLLVLASGALTVVGTLVTGSGPHAGDARQVHRIAVNWREITQLHVDLAYIVVGLSVALWFTLRAVKAPAAPRKAVLQLFAVLALQGVFGYVQYFLGLPAFVVGLHMFGSTLVWIAVLRVFLTLRERGPVPAVPGPADRLEVLEPQPAA
>NZ_CP047146.1|WP_159504444.1|2419421_2420480_+|amidohydrolase
MEGLPPLVDQYSHGAVHGELGLGSFEAHLATAVGAQGPAPAGTSYFDTRTGLAIRRWCPPLLGLEPHCPPVRYLARRREVGAFHAGRLLLRGAGIGTYLLETGARSELTSAAELSAAAEARAHEVVRLEPLAEQVADTSGSVDSFIGYTAEALYAAAQHATAFASGAMYCEGRAPDGGEVRRAADRWLRGRRPGGRLAEPALVRHLLWSAVATGLPVQLHCPDPRPLADFLRATAGLGSDLVLLPETPHHRRAAQLAAVHSHVYADTGPDPEEALGQAPFGKLLFSSGARGLPELYVTGARFFLRAMARVMGEWTAEGLCAASDGRRITEMVGSGTARRVYRLRAGDSPDTW
>NZ_CP047146.1|WP_159504443.1|2418899_2419286_+|hypothetical-protein
MLFMADTQQADEQAADGAASATTADTRADKRTAKLAGQIRAFAKTHGGSAEGQLAHIGRGRTRIALVGANGEWGNLVADSYDSAKGAADLAGITLQDDFDGELAAKVRTGPYEWSRMAGIQVGGPANP
>NZ_CP047146.1|WP_159504442.1|2417889_2418840_+|protoheme-IX-farnesyltransferase
MTAVESRPAGALSQVPGSPGNRPFGPRLKAFVALTKPRVIELLLMTTVPVMFLAARGVPDLWLVLATCVGGYLSAGGAAAYNMYLDRDIDAMMDRTSQRPLVTGMVSPRECLVFATVLAVGSTAWFWFLVNPLSAMLSLGALLFYVVVYTMILKRRTSQNIVWGGIAGCMPVFIGWSSVTNSVSWASFVLFLVIFFWTPPHYWPLSMKVTDDYKRVGVPMLPAVAGNKVVARQIVVYSWVMVAVSLLLQPLGYTGWFYTAVAVACGAFWLREAHALQSRAKAGITGAKLKEMRLFHWSITYVSLLFVAVAVDPFLR
>NZ_CP047146.1|WP_159504441.1|2415300_2417403_-|transketolase
MSNKPTTTDFEWTELDQRAVDTVRVLAMDSVQKVGNGHPGTAMSLAPAAYVLFQKLMQHDPADPDWTGRDRFVLSAGHSSLTLYIQLYLAGYGLELDDLKSFRTWGSKTPGHPEYGHTAGVETTTGPLGQGVANAVGMAMAARYERGLFDPDAPQGTSPFDHTIWAVAGDGCLQEGIAAEASSLAGHQKLGNLVLLWDDNHISIEGDTETAVSEDTLKRYEAYGWHVQRVEQLPNGDLDPAGLARALEAAKAETERPSFIAARSIIAWPAPNAQNTEAAHGSALGAEEVAATKRVLGFDPEQDFEVAGEVLAHTRAAQDRGREARAKWEKSFAAWRTANPERAAEFDRIAAGELPEGWQDHVPAFETGKSVATRAASGKVLHALGAIIPELWGGSADLAGSNNTTIDKTSSFLPEGNPLPGADPYGRTIHFGIREHSMAAEMNGITLHGNTRVYGGTFLVFSDYMRNAVRLSALMHLPVTYVWTHDSIGLGEDGPTHQPVEHLASLRAIPGLNVVRPADANETAIAWREIMRRWTKEFGVGAPHGLALTRQGVPTYEANEATVKGGYVRFEAEGADGRTAEPQVVLIATGSEVQLAVAAREQLQAEGVPTRVVSMPSVEWFEEQDQEYRDSVLPPSVRARVAVEAGIGLTWHRYVGDAGRIVSLEHFGASADGKLLFREFGFTPEAVADAARESLAAAAR
>NZ_CP047146.1|WP_159504440.1|2414147_2415266_-|transaldolase
MTDALKRLSDEGVAIWLDDLSRKRITSGNLAELIDQQHVVGVTTNPSIFQKAISAGDGYRQQVHDLATRKVTVDEAIRMITTADVRDAADILRPVFDATGGQDGRVSIEVDPRLAHNTEATIAEAKQLAWLVDRPNTLIKIPATKAGLPAITEVIGLGISVNVTLIFSLERYREVMDAYLAGLEKAKAAGLDLSLIRSVASFFVSRVDTEIDKRLEKIGTDEAKALKGKAALANARLAYQAYEEVFGTERWAALDKAGAHKQRPLWASTGVKDPAYKDTLYVDELVAPGTVNTMPEATLQATAARGEITGDTVRGTYAGAQADLDALAALGISYDDVVQLLEDEGVEKFEAAWNDLLKSTEAELSRLAPSEG
>NZ_CP047146.1|WP_159504439.1|2412608_2414141_-|glucose-6-phosphate-dehydrogenase
MSGSHGANPLRDAADRRLPRIAGPSGLVIFGVTGDLSRKKLMPAVYDLANRGLLPPGFSLVGFARREWEDEDFAHEVYEAVKQHSRTPFREEVWQQLVQGCRFVQGNFDDDEAFETLKDTINELDKAQGTGGNFAFYLSVPPKFFPKVVQQLKKHGLADQKADSWRRAVIEKPFGHDLASAQELNRIVHEVFPPNEVFRIDHYLGKETVQNILALRFANTMFEPLWNRGYVDHVQITMAEDIGIGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPASFEADALVAEKTKVLGAVRLPRDLGKETVRAQYTAGWQGGEKVVGYAEEDGIDPKSKTDTYAAIKVGIDNRRWAGVPFYLRTGKRLGRRVTEIAVVFQRAPHSPFDHTATEELGQNALVIRVQPDEGVTVRFGSKVPGTSMEVRDVSMDFAYGESFTESSPEAYERLILDVLLGDANLFPRLEEVELSWKILDPIETYWDKHGKPAQYPAGTWGPDEADEMLARDGRSWRRP
>NZ_CP047146.1|WP_159504438.1|2411547_2412612_-|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA
MKIDLTETTASKINKALVQGRRAVGTPAIGMVLTLVIVTDEENAYDALKAANEASREHPSRTLVVVKRVSRSPRDRAKARLDAEVRVGTDAGTGETVVLRLYGEAIDHAQSVVLPLLLPDAPVVVWWAVNAPLDPAKDPLGALAQRRVTDAYASEEPIRELSARADTYTPGDTDLSWTRITPWRSMLAAALDQSPCTVTSAVVEGEEFNPSCELLAMWLASRLDVPVQRTVSAGPGLTAVRLESSGSGTIVLDRPDGSLATLSMRGQPDRAVALKRRETSELLAEELRRLDPDDIYAAALKYGVERIGQPDGQPAAPAAADRQAAPAAGTSADAGTTPAKAAAKKAPAKKAAAK
>NZ_CP047146.1|WP_159504437.1|2410768_2411551_-|6-phosphogluconolactonase
MSTPQVVVHRDKELMAKAAAARLITKIVDAQAARGSASVVLTGGRNGNGLLAALAEAPARDAVDWSRLDLWWGDERFLPDGDPERNYTQARAALLDGVPLDPARVHPMEPAGGRFGNDADAAAEEYALELAAAAGPEDHGPVPSFDVLLLGVGPDTHVASLFPELPAVYERDRTVVGVHGAPKPPPTRITLTLPAIRAAREVWLLAAGEDKAGAAAIALSGAGEVQAPAAGARGRSRTLWLLDEAAASQLPRSLYPPASS
>NZ_CP047146.1|WP_159509879.1|2409052_2410708_+|glucose-6-phosphate-isomerase
MNAEGRSRLDQLPEWTALRKHREQLGEVHLRELFAKDPDRARRFTLQVGDLHLDFSKHLVTDETLRLLRELAAATGVAELRDAMFRGEKINITENRSVLHTALRAPGSAVITSDGVNVVPAVHSVLTKMATFADRVRSGDWKGHTGRRIKTVVNIGIGGSDLGPAMAYEALRAYTHRDMQFRFVSNVDGADLHEAVRDLDPAETLFVIASKTFTTIETITNATSARDWLLSGLGAGGENAVAKHFVALSTNAEKVAEFGIDTVNMFEFWDWVGGRYSYDSAIGLSLMIAIGPERFREMLAGFHLVDEHFQSAPPEENVPLLLGLLGIWYGNFWDAQSHAVLPYSHYLSKFTAYLQQLDMESNGKSVDRQGHQVNWQTGPVVWGTPGTNGQHAYYQLLHQGTKVIPADLIGFARPVDDLRPGLVAQHDLLMANLFAQGQALAFGKTPDEVRAEGVAEELVPHRTFRGNHPTSTILASELTPSVLGQLIALYEHKVFVQGAVWNIDSFDQWGVELGKVLARRVEPALTEGADVPGLDASTAGLVAKYRELRGR
>NZ_CP047146.1|WP_159504447.1|2423760_2424618_+|ArsR-family-transcriptional-regulator
MKYASEDQERPAVQPTADPVSSAPERPAQAGPAPAPHDEQQGTRNRVARSILDHGPSTAAELALRLELTQAAVRRHLDALAAEGVVEPREKRVYGTRGRGRPAKAFALTDCGRDAFDQAYDQLASDALRWIAQSAGGGEEGEAAVAAFARARLAAQAEGYRKAVEAADPEARTEALAKALTADGYAATARSAPNPQLGEQLCQHHCPVAHVAEQYPQLCEAETEVFSRLLGTHVQRLATIAHGDGVCTTFVPKAGAGKATHGSTAHSSTTKTTTASASTAGRNPA
>NZ_CP047146.1|WP_159504448.1|2424614_2426036_+|Fe-S-cluster-assembly-protein-SufB
MTLPTETAHPELEGLGKYEYGWADSDVAGASAKRGLSEEVVRDISGKKDEPEWMLKLRLKGLKLFDKKPMPQWGSDLSGIDFDNIKYFVRSTEQQAASWEELPEDIKNTYDKLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGVIFLDTDTALKEHPELFQEYFGTVIPVGDNKFASLNTAVWSGGSFIYVPKGVHVDIPLQAYFRINTENMGQFERTLIIVDEDAYVHYVEGCTAPIYKSDSLHSAVVEIIVKKGGRCRYTTIQNWSNNVYNLVTKRAVAYEGATMEWVDGNLGSKVTMKYPAVYLMGEHAKGETLSIAFAGEGQHQDAGSKMVHMAPNTSSNIVSKSVARGGGRTSYRGLVEIGEGAAGSKSNVLCDALLVDTISRSDTYPYVDVREDDVSMGHEATVSKVSEDQLFYLMARGLSEQEAMAMIVRGFVEPIARELPMEYALELNRLIELQMEGAVG
>NZ_CP047146.1|WP_159504449.1|2426095_2427280_+|Fe-S-cluster-assembly-protein-SufD
MAEAQNIPAGSTTTGSIAVAAESTVATRMSAPPSYDVADFPVPHGREEEWRFTPLARLRGLHDGSAEAGGPDLKVDITAPDGVTHELVDRTDPRVGKAGKPVDRVAAQAYSSFEKASVVTVPKETVLTEPIRITVHGEGGTAYGHQVVELGAFAEAVVVIDHTGDAVLAANVDYLLGDGAKLTVVSVQDWDDTAVHCGQHNALVGRDATFKSVVVTFGGDLVRLHPRIDYAGPGGEAELYGLYFTEQGQHQEHRLFVDHDTPNCRSHVTYKGALQGQDAHAVWIGDVLIQAAATGTDTYELNRNLVLTDGARVDSVPNLEIETGEIVGAGHASATGRFDDEQLFYLMARGVPADEARRLVVRGFFAELVQQIGLPDVEERLMNKIEAELEASAA
>NZ_CP047146.1|WP_016578643.1|2427276_2427594_+|non-heme-iron-oxygenase-ferredoxin-subunit
MTYVRAAALSELEEDTPKRVEIDGTPISLVRTEGEVFAINDICSHANVSLSEGEVEDCSIECWLHGSSFDLRTGKPSGLPATRPVPVYPVKIEGDDVLVSVTQES
>NZ_CP047146.1|WP_159504450.1|2427601_2428366_+|Fe-S-cluster-assembly-ATPase-SufC
MATLEIHDLHVSVEAENGQREILKGVDLTVKQGETHAIMGPNGSGKSTLAYSLAGHPKYTITGGTVTLDGEDVLEMSVDERARAGVFLAMQYPVEVPGVSVSNFLRTSATAIRGEAPKLRLWVKEVKEAMERLHMDPSFAERNVNEGFSGGEKKRHEILQLELLKPAIAILDETDSGLDVDALRIVSEGVNRVRETGQVGTLLITHYTRILRYIKPDHVHVFANGRIAESGGPELADKLEAEGYEAYVKGGTTA
>NZ_CP047146.1|WP_159504451.1|2428362_2429619_+|SufS-family-cysteine-desulfurase
MTQLPGLLDTEAIRKDFPLLDRQVHDGKKIVYLDNAATSQKPRQVLDALSAYYERHNANVHRGVHVLAEEATALYEGARDKVAAFINAPSRDEVIFTKNASESLNLVANMLGWADEPYRVDRETEIVITEMEHHSNIVPWQLLSQRTGAKLKWFGITDDGRLDLSNIDEIITEQTKIVSFTLVSNIMGTVNPVETIVRRAQEVGALVCIDASQAAPHMVLDVQALQADFVAFTGHKMCGPTGIGVLWGRQELLEDLPPFLGGGEMIETVSMHSSTYAPAPHKFEAGTPPIAQAVGLGAAVDYLTSIGMDRIAAHEHAITEYAVKRLLEVPDLRIIGPSTAEDRGATISFTLGDIHPHDVGQVLDEQGIAVRVGHHCARPVCLRYGIPATTRASFYLYSTPAEVDALVEGLEHVRNFFG
>NZ_CP047146.1|WP_159504452.1|2429638_2430097_+|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MKLDSMYQDVILDHYKHPHGRGLRDGDAEVHHVNPTCGDEITLRVRLEGTTIEDVSYEGQGCSISQASASVLNDLLVGKQLGEAQRIQETFLELMQSKGQVEPDDAMEEVLEDAVAFAGVSKYPARVKCALLSWMAWKDATAKALSQEAKTA
>NZ_CP047146.1|WP_159504453.1|2430093_2430435_+|DUF59-domain-containing-protein
MTDTPATTTTKPASEEEVREALYDVVDPELGIDVVNLGLIYGIHIDDANIATIDMTLTSAACPLTDVIEDQAKSATDGIVSELKINWVWMPPWGPDKITDDGREQLRALGFNV
>NZ_CP047146.1|WP_159504454.1|2430580_2430901_+|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter
MVYLTLAGAILSEILATTAMKYSHGFTKLWPSVGTTLGYLVAFALLARTLKSMSVGTTYAIWSGAGTAVIAAIGMVFLGESTSWLKILGVLLVIAGVVVLNLDGAH
>NZ_CP047146.1|WP_159504455.1|2430900_2431440_+|TetR-family-transcriptional-regulator
MARRYDPDRRQRIIDAAIAVVGERGIAGLSHRAVAAAADVPLGSTTYHFATLDELLVAALRQANGGWLEDFARWVAGIDPAVPLADEVARLVEETLAGDRSRVELEYELYLAALRHEAVRPIAAECLDEMVALLGRRIGDPATARAVVAFADGLVLQHLLTGRPFERALVRDGLAGVLG

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Crispr_ID: NZ_CP047146_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_7

2489281-2489375

Orphan

Consensus_repeat	Method
GCCGGCGGCGCAGCGTCGCCGGC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP047146_7

>merge|NZ_CP047146|7|2489281-2489375|CRISPRCasFinder
GCCGGCGGCGCAGCGTCGCCGGCTGCCTCAGTCTCTCCGGATCCGGCGGATCGCGCAGACCGCCCGGGGTCCGCCGGCGGCGCCGCGTCGCCGGC

>NZ_CP047146|7|7|2489281-2489375|CRISPRCasFinder
GCCGGCGGCGCAGCGTCGCCGGC	TGCCTCAGTCTCTCCGGATCCGGCGGATCGCGCAGACCGCCCGGGGTCC
GCCGGCGGCGCCGCGTCGCCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159509884.1\|2490557_2491580_-\|DEDDh-family-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|180377
NZ_CP047146.1\|WP_159504506.1\|2492425_2493226_+\|acetoacetate-decarboxylase	unknown	unknown	gnl\|CDD\|377649
NZ_CP047146.1\|WP_159504500.1\|2485850_2486456_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	unknown	unknown	gnl\|CDD\|380217
NZ_CP047146.1\|WP_159504508.1\|2494248_2495565_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|225070
NZ_CP047146.1\|WP_159504494.1\|2480737_2482336_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP047146.1\|WP_159504498.1\|2484776_2485154_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377129
NZ_CP047146.1\|WP_159504505.1\|2491678_2492299_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP047146.1\|WP_159504497.1\|2484560_2484761_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_078487029.1\|2482620_2482908_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159504509.1\|2495561_2496851_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|368185
NZ_CP047146.1\|WP_159504511.1\|2500686_2500878_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159504501.1\|2486662_2487418_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187602
NZ_CP047146.1\|WP_159504495.1\|2483023_2483803_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_CP047146.1\|WP_159504496.1\|2484044_2484524_+\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|377129
NZ_CP047146.1\|WP_159504504.1\|2490260_2490494_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159504502.1\|2487422_2489207_-\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NZ_CP047146.1\|WP_159509885.1\|2498738_2500355_+\|TIGR03086-family-protein	unknown	unknown	gnl\|CDD\|274424
NZ_CP047146.1\|WP_159504499.1\|2485150_2485843_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159504510.1\|2497921_2498677_+\|lysoplasmalogenase	unknown	unknown	gnl\|CDD\|377946
NZ_CP047146.1\|WP_159504507.1\|2493239_2494133_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|180458

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159509884.1\|2490557_2491580_-\|DEDDh-family-exonuclease	gnl\|CDD\|180377	PRK06063, PRK06063, DEDDh family exonuclease.	7.58484e-160
NZ_CP047146.1\|WP_159504506.1\|2492425_2493226_+\|acetoacetate-decarboxylase	gnl\|CDD\|377649	pfam06314, ADC, Acetoacetate decarboxylase (ADC). This family consists of several acetoacetate decarboxylase (ADC) proteins (EC:4.1.1.4).	8.12536e-46
NZ_CP047146.1\|WP_159504500.1\|2485850_2486456_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	gnl\|CDD\|380217	NF033218, anchor_AmaP, alkaline shock response membrane anchor protein AmaP. The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.	3.86271e-13
NZ_CP047146.1\|WP_159504508.1\|2494248_2495565_+\|amidohydrolase-family-protein	gnl\|CDD\|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	1.1702e-18
NZ_CP047146.1\|WP_159504494.1\|2480737_2482336_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NZ_CP047146.1\|WP_159504498.1\|2484776_2485154_+\|hypothetical-protein	gnl\|CDD\|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	0.000107282
NZ_CP047146.1\|WP_159504505.1\|2491678_2492299_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	9.47112e-09
NZ_CP047146.1\|WP_159504509.1\|2495561_2496851_+\|amidohydrolase-family-protein	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	1.67574e-26
NZ_CP047146.1\|WP_159504501.1\|2486662_2487418_-\|SDR-family-oxidoreductase	gnl\|CDD\|187602	cd05344, BKR_like_SDR_like, putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR. This subgroup resembles the SDR family, but does not have a perfect match to the NAD-binding motif or the catalytic tetrad characteristic of the SDRs. It includes the SDRs, Q9HYA2 from Pseudomonas aeruginosa PAO1 and APE0912 from Aeropyrum pernix K1. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	4.16472e-74
NZ_CP047146.1\|WP_159504495.1\|2483023_2483803_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	2.7559e-51
NZ_CP047146.1\|WP_159504496.1\|2484044_2484524_+\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	5.69698e-33
NZ_CP047146.1\|WP_159504502.1\|2487422_2489207_-\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	3.73716e-129
NZ_CP047146.1\|WP_159509885.1\|2498738_2500355_+\|TIGR03086-family-protein	gnl\|CDD\|274424	TIGR03086, TIGR03086, TIGR03086 family protein. This family, like pfam07398 and TIGRFAMs family TIGR030834, belongs to the larger set of probable enzymes defined in family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized.	2.90383e-21
NZ_CP047146.1\|WP_159504510.1\|2497921_2498677_+\|lysoplasmalogenase	gnl\|CDD\|377946	pfam07947, YhhN, YhhN family. The members of this family are similar to the hypothetical protein yhhN expressed by E. coli. Many are annotated as possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues. A human member of this family, formerly known as TMEM86B, is a lysoplasmalogenase that catalyzes the hydrolysis of the vinyl ether bond of lysoplasmalogen. Putative conserved active site residues have been proposed for the YhhN family.	2.0425e-18
NZ_CP047146.1\|WP_159504507.1\|2493239_2494133_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|180458	PRK06194, PRK06194, hypothetical protein; Provisional.	4.43685e-126

>NZ_CP047146.1|WP_159504502.1|2487422_2489207_-|glycoside-hydrolase-family-15-protein
MHPRIEDYALIGDLQTAALVGRDGSIDWLCLPRFDSPACFAALLGDTDNGHWRLAPHSPEARARRSYRGDSLLLDTVWETPTGSVRVTDFMPQRDRMPDVVRIVEGLHGSVAMRGVLRLRFDYGRVVPWMRAAEGSRVAIAGPDSVWLRTPAGGRTYGKDFSTCSDFTVAAGERAAFVLTWHPSHEPRPNLIDPFQALEDTLEDWGDWSARCRYTGPYRAAVIRSLITLKALTYAPTGGIVAAPTTSLPEEPGGVRNWDYRFCWLRDASLTLNSLISAGYLDEAGAWRDWLLRAVAGAPADLQIMYGLGGERRLPEAEVPWLSGYADSRPVRIGNAAVEQRQLDVYGEVIDSFHVARTAGLPAEAHAWSIQRTLVDYLAATWRDPDEGIWEIRGPRRHFVYSKVMAWVAADRAVRAIEADPKLSGDVDRWRAMRDEVHREVCERGYDAERGAFTQFYGSAELDAATLLIPRVGFLPGDDPRVRSTVDTVRRELTTGGLVRRYSTADGSVDGLPGGEGTFVVCSFWLADALRLTGRHKEARELFERLLALRNDVGLLSEEYDPVAGRQLGNFPQAFSHIGLVGTAFELLGATGAD
>NZ_CP047146.1|WP_159504501.1|2486662_2487418_-|SDR-family-oxidoreductase
MDLGLTDRTYLVTGATRGLGFATARALVADGANVVVTGRTEESAGKAAAALGDRALGVAADNADPESAARLVSAARERFGRLDGVLISVGGPAPGTTADNTDDQWRTAFESVFLGAVRLAREAAAVLDEGGVIGFVLSGSVHEPIPGLTISNGLRPGLAGFAKSLADELGPRGIRVLGVLPGRIATDRMTQLDSLSGDPEGTRARNSATIPLGRYGRPEEFGRAAAFLLSPAASYITGVMVPVDGGARHGF
>NZ_CP047146.1|WP_159504500.1|2485850_2486456_+|alkaline-shock-response-membrane-anchor-protein-AmaP
MPRARATVNRLLLGLTGAVLLAAGGLVLLGGLDLPARLHLGLPGGEPWARPGAVLLSARDRTRWTDRGWWWPAVIAALVVLVLLFLWWLLAQLRRYRLGEVLVDSGDGEGALVRGRSLETVLTADAESLDGVERAVVLLTGRRTEPRLRALLALAPHADPGTVVLRLSDEAVAHARTSAGLARLPAEVRLRAVRHRPERVS
>NZ_CP047146.1|WP_159504499.1|2485150_2485843_+|hypothetical-protein
MSGAGDARPGARRMPAPGERPGAAGGLTGPAGNARPASGGALPDTGPAFGGRAGRFWSARRVPSALVALVLLAAAGLLLYDVAAVRAHRPAAAWRRGLADELATRHLDDPWVQAGAAAAVLLGIWLIVLAVTPGLRAVLPMRRTAPGVRAGLDRPAAALVLRDRAMEVAGVRSVRMTVGRRRVYARAVAHFRELGAVRRDLDTALGDGLRHLGLAHRPALTVYVRRPRKG
>NZ_CP047146.1|WP_159504498.1|2484776_2485154_+|hypothetical-protein
MSAPAGAAGVPAGERGATVVADRVVAKIAARAAREALRAACPGDPTDAHATVTVRRRDVRPPFGEARLHLAVELGYPVDIGVHARLVRRHVTERVRELAGMAVSEVAVRVERLHSPLLADREWVR
>NZ_CP047146.1|WP_159504497.1|2484560_2484761_+|hypothetical-protein
MSMAVVGLVAGMALGFAGYFGGFGAFVLVAALGAVGFMAGRLFEGDLAAGDFFRAPRTGDRDGRRR
>NZ_CP047146.1|WP_159504496.1|2484044_2484524_+|Asp23/Gls24-family-envelope-stress-response-protein
MTESQHRAAAAKPPVKRGGGDPGARGRTTIADGVVEKIAGLAARDVLGVHAMGSGLARTFGAVRDRVSGGSRSAPAMRGVKAEVGEVQTALDLEIVVDYGVAIADVARAVRENVISAVERMTGLEVVEVNIAVSDVQLPEEEDEADEADGAGAPEPRLQ
>NZ_CP047146.1|WP_159504495.1|2483023_2483803_+|enoyl-CoA-hydratase/isomerase-family-protein
MTLLDKHGVRLAVDEAIATVTLANAAKRNAQSPAMWRALAEAGSLLPGNVRIVVLRGEGKSFSAGLDRQAFTPEGFDGEPSFLDLARGTDGELDATIAEYQEAFTWWRRNDLVSIAAVQGHAIGAGFQLALACDLRVVAQDVQFAMRETSLGLVPDLTGTHPLVGLVGYARALEICATGRFVYAEEAERIGLANLVVPGDALDAAVSDLAAALTAAPRDAVIETKALLAGAAGRTYEEQRRAERAAQARRLRDLAGVGE
>NZ_CP047146.1|WP_078487029.1|2482620_2482908_+|hypothetical-protein
MARKPGRGDHESPERTSHEEARVAETLKKGSRVTGAAREKLAADLKKKYDSGASIRALAEETGRSYGFVHRMLSESGVVLRGRGGATRGKKAASV
>NZ_CP047146.1|WP_159504494.1|2480737_2482336_+|ATP-binding-cassette-domain-containing-protein
MITASGLELRAGARILIESASFRVAKGDRIGLVGRNGAGKTTLTKVLAGEGIPAGGSVTRSGEVGYLPQDPRTGDLDVLARDRILSARGLDAVLRKMRENEDRMANGKGATREKAMKKYERLETEFLTKGGYAAEAEAATIAASLGLPDRILGQPLHTLSGGQRRRVELARILFSDSDVLLLDEPTNHLDADSIAWLRDYLKTYRGGFIVISHDVDLVETVVNKVFYLDANRSQIDVYNMGWKLYQQQREADEKRRKRERANAEKKAAALNSQADKMRAKATKTVAAQNMAKRADKLLAGLEAVRASDKVAKLRFPDPAPCGKTPLTAEGLSKSYGSLEIFTDVDLAIDKGSRVVILGLNGAGKTTLLRLLAGVETPDTGEVRPGHGLKLGYYAQEHETLDPDRTVLENMRSAAPDMDLVDIRKTLGSFLFSGDDVDKPAGVLSGGEKTRLALATLVVSSANVLLLDEPTNNLDPASREEILGALHTFTGAVVLVTHDEGAVDALAPERIILLPDGVEDLWGQDYADLVALA
>NZ_CP047146.1|WP_159504504.1|2490260_2490494_-|hypothetical-protein
MARCEVCGNDYGMTFEVHAQGAVHVFDCFSCAIHRMAPICEHCRVQIIGQGVEAEGQWYCGAHCARSAGRVGIVDRV
>NZ_CP047146.1|WP_159509884.1|2490557_2491580_-|DEDDh-family-exonuclease
MAAAPPIAPKIGQQPGPQTPPADWPSGYPQGYAVVDVETTGLARDDRIISAAVYQLDAQGAFQDSWYTLVNPQRDPGPVWIHGLTSEVLDGAPLFPDIVPELSRRLADRVLVAHNAMFDWSMIAREYARAAATAPVRQRLCTIALSKELGLPLPNHKLESLAAHYGVVQERAHHALDDARVLAEAFRPSLRRAARQNLRLPLLTCQPLTEWSDSAAPRQRAAGSAYRPTSWRPSRKRPACPYPNPGRYEAGGRLVQGMRVAFSGDTSVDRELLEDRAIEAGLHVATSVSRLTSLLVTNDPEARTSKTAKAAAFGTAVVDEAAFMQLLQDVEPAGGAPASG
>NZ_CP047146.1|WP_159504505.1|2491678_2492299_-|TetR-family-transcriptional-regulator
MTRTALTGEEVLRTAARLIRAHGPEALTMRRLAAELGTAVTSIYWHVGNRESLLDALVERTVQEMGEIRPTGSTPQARVVSVARALHTALRERPQLIAMVHERGLTERMFLPAQQALVHEMHAAGLRGERAAEAVRAVQFQVVGFVLVERNRERSPAQHPSEGELWDAPTAGHDPALARALAAPADAGHLFRVSLEALVASLLGPA
>NZ_CP047146.1|WP_159504506.1|2492425_2493226_+|acetoacetate-decarboxylase
MARIRYGARTEAEIAATRAAGTKLPDIWSTGVVALWETDPDAVAAVLPPPLKPTARPLVRATISTVDLPGYPLGAGSVAVAAVHNGTEGWYPLVMPMTHERALTGGREVFGEPKKLGEVTVERAGLVVRAALARHGIAFVEVRGAVGGPLPLPEPEYRTDFYFKFLPAVDGSGFDADPVLVHCRRHEKVRRLERVTGDVVLRESMYDPVADLPVHTLVGITLGEKTTDQSGTVAERVDGRALLPYIHQRYDDPMQTLDGPPEGSVR
>NZ_CP047146.1|WP_159504507.1|2493239_2494133_+|SDR-family-NAD(P)-dependent-oxidoreductase
MELRTGQVAVVTGAASGIGRAMARRFAAEGLKVVLADVEEAPLRATADELLADGAELLARTADVGVREDVEALAAAAYETFGAVHVLCNNAGVGSGAEGRMWQHDPADWQWAFAVNVWGVFHGVQCFLPRMLASGEPGHVVNTSSTDGGVAPLPTASVYAVTKAAVVTLTESLYAHLKAEGAPIGASVLFPGPHMLRTGLWESHRNRPARYAKSRPRRTPYRSLAEWEAAMKEAGQEVAFTPVEDVAEQVVDGIRAGRFWMLPAAEHTDAQIRARSRSMLDRADPSYLERFILDRRD
>NZ_CP047146.1|WP_159504508.1|2494248_2495565_+|amidohydrolase-family-protein
MTDLTHDTDPHPHHQDPYLVISSDCHAGLPTEEYRPYLDPRFHRPFDEFLAGRDARRAAMTRLGVRNETFAAKWFEDNEEGLRGGWDPAQRAKELDGDGVAAEVVFPDADAVDSSTAAPFGVGLGLSGDQDPELGMAGARAHNRWLAEFCATDPERHCGVALLPVTGDIDAAVDEIHRARNAGLGALMIPAMWGGNAPYHDRRYDPVWAAAAETGMPVLTHSGAAPREEYGDHLGIFVSEVTWWPARPLWFLLWSGVFERHPGLRFGIAESGCWWLPNLLWFMDRLYLGAHGGKKLSPFAELKRPPHEYLDRNVFVCATNTKRRELAQRYEIGVDNILWGSDYPHPEGTWPRTREWLADTFHDIPVAETRRMLGESAADVFGFDRAALAPLARRIGPTPADLGQPADQGPVAASWRRARDTGRHWLTGHDFPYTGVTS
>NZ_CP047146.1|WP_159504509.1|2495561_2496851_+|amidohydrolase-family-protein
MTAAHRGDRTTASPTSDPLAAPGARYTVISADCHAGADLLDYRPYLPSRYHEEFDAWAATYVNPHEDLLADTADRNWNSARRLADLEADGIVGEVVFPNTIPPFFPSASLMAPAPTGEELALRWAGLGAHNRWLADFCAQAPGRRAGVAQILLNDVDEAVREVRRAREAGLTGGILLPGTPPGSGLPELHSPVYDPLWAVCAELGVPVNHHGGSASPPLGDEPAARAVFMVETTWFSHRALWHLVFGGAFRRHPDLTLVLTEQGSGWIPGVLDMLDYYHGRLVASAARATTAESRFGAGLADAMGASPGEVWRANCYVGASFMRPHEVPLRDRIGLDKIMWGSDFPHDEGTHPYSRQALRAAYAGLPPAEVAAMTGANAARVYGFDLAALAPVAARVGPTVEEIAEPLKEPPADATSPAFAEGAALRVW
>NZ_CP047146.1|WP_159504510.1|2497921_2498677_+|lysoplasmalogenase
MRAPAPRPRAARIVLAVFAVLAAAHLLALVAQAAAAPGSTAAALAGTAVHLTKPALMPLLAAHVLLRGGPPLLAGALLLGCGGDTFLQIGGGTAFLVGMGSFAAGHVCYLLLFARPGRRPAGRRSLPVAAAAAYAVALVATVALLWPDLPAALRVPVAGYSLLLTAMACGALRAGPRAAAGGLLFLLSDTLIASGIAHWPQLPAPQFWIMVSYTAAQFALAAGVLAAAGGPDHPAADAHPSPAYREAVREA
>NZ_CP047146.1|WP_159509885.1|2498738_2500355_+|TIGR03086-family-protein
MYEDGTGLLSIGALSRLTGVSVKTIRNWSDQDLLPPAARTPAGYRLYGPDAPARLEIVRSLRELGIGTAAIRAVLHRERSLGDTAERWADALDAQIRTLRLQRSVLRTVAARGTAAEELPQMTRLARLSAEERRRIVADVVEDALDGVAAPAYRSGLLAATPDPPEDPTPEQLDAWVELAALVRDPELGAALRRLAEFSARTAPAQPTGAADAGDPDAADPAAATEAAVRVAELMRTRADAAVAAGIAPDSPVAEPVLAELIAAWIPTQATTHDPPAEDGPAARTRLLEQLETVAEPLVERYWQLLCTATGRPAPPRWGAAGTWTAAALRAHRTPSEPDRSAFERLADTDPERVLAGYAQVARDVGALVAAVRPDDLRLSTPCAGWTVRELLNHMVWENLMATSIAAGAPRGDHTADHLGDGPDGHIVAFEESARTALAVFTGSGMLHRTFGPYEAPGGLLVQQVTVELLAHGWDLARAVGAPTDLAPEVAAEVLEAARLIYGAAPRTEGSSFAPERPAPPGATAADRLAAYLGRLPD
>NZ_CP047146.1|WP_159504511.1|2500686_2500878_-|hypothetical-protein
MTPPPPQDPPRPGPRRRPYGSVRLPGPIALAPSLPRPVADARRWYGRRIALPPLSLSTLRRPE

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Crispr_ID: NZ_CP047146_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_8

3090387-3090474

Unclear

Consensus_repeat	Method
TCCCACGTTGCCGGGTGCGGCGC	CRISPRCasFinder

1 spacers

cas1

The CRISPR arrays of NZ_CP047146_8

>merge|NZ_CP047146|8|3090387-3090474|CRISPRCasFinder
TCCCACGTTGCCGGGTGCGGCGCGGTGGCGCCTGCGGCGGGCCCCTCCGCTGCGCTTTGCCTGCTCCCGACGTTGCCGGGTGCGGCGC

>NZ_CP047146|8|8|3090387-3090474|CRISPRCasFinder
TCCCACGTTGCCGGGTGCGGCGC	GGTGGCGCCTGCGGCGGGCCCCTCCGCTGCGCTTTGCCTGCT
CCCGACGTTGCCGGGTGCGGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159504941.1\|3096128_3097418_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP047146.1\|WP_159504946.1\|3104429_3104855_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159504945.1\|3102123_3103170_-\|CRISPR-associated-endonuclease-Cas1	cas1	pfam01867_cas1_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187766
NZ_CP047146.1\|WP_159509944.1\|3084575_3085565_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224525
NZ_CP047146.1\|WP_159504942.1\|3097414_3098080_+\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP047146.1\|WP_159504936.1\|3085791_3086748_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP047146.1\|WP_159504935.1\|3083128_3084412_+\|aldolase	unknown	unknown	gnl\|CDD\|367449
NZ_CP047146.1\|WP_159504940.1\|3094530_3095256_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NZ_CP047146.1\|WP_159504943.1\|3098120_3098885_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP047146.1\|WP_159504931.1\|3080030_3080819_+\|electron-transfer-flavoprotein-subunit-beta	unknown	unknown	gnl\|CDD\|238847
NZ_CP047146.1\|WP_159504934.1\|3082403_3082922_-\|DUF664-domain-containing-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP047146.1\|WP_159504944.1\|3100354_3101572_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP047146.1\|WP_159504933.1\|3081950_3082265_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NZ_CP047146.1\|WP_159509945.1\|3087092_3088976_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP047146.1\|WP_159504939.1\|3093932_3094361_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|211538
NZ_CP047146.1\|WP_159504938.1\|3090901_3092260_-\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|236127
NZ_CP047146.1\|WP_159504937.1\|3089282_3090317_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239217
NZ_CP047146.1\|WP_159509946.1\|3099077_3100214_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NZ_CP047146.1\|WP_159504930.1\|3079312_3079819_+\|flavin-reductase	unknown	unknown	gnl\|CDD\|214900
NZ_CP047146.1\|WP_159504932.1\|3080886_3081849_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159504941.1\|3096128_3097418_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	7.8959e-58
NZ_CP047146.1\|WP_159504945.1\|3102123_3103170_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	8.28348e-31
NZ_CP047146.1\|WP_159509944.1\|3084575_3085565_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.36219e-100
NZ_CP047146.1\|WP_159504942.1\|3097414_3098080_+\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.58372e-65
NZ_CP047146.1\|WP_159504936.1\|3085791_3086748_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	8.09097e-62
NZ_CP047146.1\|WP_159504935.1\|3083128_3084412_+\|aldolase	gnl\|CDD\|367449	pfam03328, HpcH_HpaI, HpcH/HpaI aldolase/citrate lyase family. This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.	4.14242e-06
NZ_CP047146.1\|WP_159504940.1\|3094530_3095256_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	1.07918e-11
NZ_CP047146.1\|WP_159504943.1\|3098120_3098885_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	6.35621e-14
NZ_CP047146.1\|WP_159504931.1\|3080030_3080819_+\|electron-transfer-flavoprotein-subunit-beta	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	7.83899e-80
NZ_CP047146.1\|WP_159504934.1\|3082403_3082922_-\|DUF664-domain-containing-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	3.86024e-44
NZ_CP047146.1\|WP_159504944.1\|3100354_3101572_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.16525e-32
NZ_CP047146.1\|WP_159504933.1\|3081950_3082265_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	3.20975e-19
NZ_CP047146.1\|WP_159509945.1\|3087092_3088976_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.80645e-91
NZ_CP047146.1\|WP_159504939.1\|3093932_3094361_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|211538	TIGR00026, Hypothetical_protein_Rv1261c/MT1299/Mb1292c., deazaflavin-dependent oxidoreductase, nitroreductase family. This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity].	3.04129e-08
NZ_CP047146.1\|WP_159504938.1\|3090901_3092260_-\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|236127	PRK07907, PRK07907, hypothetical protein; Provisional.	0
NZ_CP047146.1\|WP_159504937.1\|3089282_3090317_+\|NUDIX-domain-containing-protein	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	3.59272e-18
NZ_CP047146.1\|WP_159509946.1\|3099077_3100214_-\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.97062e-74
NZ_CP047146.1\|WP_159504930.1\|3079312_3079819_+\|flavin-reductase	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	9.45844e-45
NZ_CP047146.1\|WP_159504932.1\|3080886_3081849_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	8.85483e-108

>NZ_CP047146.1|WP_159504937.1|3089282_3090317_+|NUDIX-domain-containing-protein
MIVWLNGTFGAGKTTAAHELLDLLPGSTLYDPELLGAGLRLMLPAKRFEEVDDYQDLPSWRRMVVDTAAALLTEVPGPLVTPMTLLRQEYRDEIFGALAARRIPVRHVLLHAEETILRTRIAHREETPGDAEGSASVRRWCLEHLGPYAQALDWLKNDAHVVDTTELTPRQTAERVAEAVRTGAGACDIVQTPEPTAETLAAGVLLFDDRDRVLLVDPTYKPGWEFPGGIVEPGEAPAHAGVREVAEELGIQLPCAPRLLVLDWEAPKPPGFGGLRLLFDGGTLTGDRIRQLLLPGSELRDWRFVTEAEAETMLPPVRWNRLRWALRARERGCPLHLEAGVPLG
>NZ_CP047146.1|WP_159509945.1|3087092_3088976_+|protein-kinase
MGVVCRADDQVLGREVALKVLRAYTDASAPELADLRTRMQREARAAARIRHAGVVTVHDVIDEAGRPVIVMELVDGPSLDDAIDRRGPLDPREIARIGAAVMDALDAAHRAGVLHRDVKPGNVLLDSSGRVVLTDFGIASIEAPGDGATTNITRSGELVGSLDYLPPERAQGMDPSPASDIWSLGMTLYAAVEGGGAPFRRTSVYSTLTAIVTEPLPAPRRAGPLAPVLYALMAKNPADRPSAAQARSMLEAVADGRDPGVTPPPAPQPGSPYVPTATNVRGAAAPGSAADAPPGAASIGGANAGAPPASWLSGPGSQGAPTPQERTSGAPQGPAQGPLQDPPGVTAGPFVGATGPHPYPGGRGVTPDGDTARLPARRRRRVLLAAAAVLAVLATGGGVTYALVGGSGDPTEADGRQSAAPATAPARPGEPSVTTGQGEANGKGKEQSASPSAPGKPAGGASSQPSKPAGTGGGSGGQAAGGAASGGGQGGATGGLIGGAQGGGSGGSGGTGGSGGGTTTGGGAATGGGGPTQGPACTATAGGKANCAVWRTATSYTASFQQVGHLNAGTNYFYCQANLGRRETYGKWTNVWWAKTDDDSGNSGVYVSVVYLTGGENDQPVPGLRTC
>NZ_CP047146.1|WP_159504936.1|3085791_3086748_+|ROK-family-protein
MQTDLSAALDIGGTKIAGALVDAHGRMIVRAARPTPADRDGATVMGAVAEVVRELAAGPDWARVAAVGIGSAGPVDASAGTVSPVNIPGWRGFPLVAGVRELVGGRPVALVGDGVAMTAAEHWQGAARGHDNALCMVVSTGVGGGLVLNGRLHPGPTGNAGHIGHISVDLDGDPCPCGGRGCVERIASGPNIARRALANGWRPGPDGDASAAAVAAAAHAGDLVALRSFERAAQALAAGIAATATLVEIDIAVVGGGVAGAGEVLFAPLRAALRDYATLSFVSELTVVPAQMGTHAGVVGAAAVAAQQSRLDAFAPAR
>NZ_CP047146.1|WP_159509944.1|3084575_3085565_-|substrate-binding-domain-containing-protein
MKDVAARAGVGLKTVSRVVNGEAGVTPDTERRVQEAIAALGFRRNDSARILRKGRTASIGLVLEDLADPFYGPLSRAVEEVARSHGALLINGSSAEDPAREQELVLALCARRVDGLVVIPAGDDHRYLEPEIAAGVATVFVDRPAGRIDADVVLSDNFGGARDAVAHLIAHGHRRIGFIGDQPRIHTARERLRGYRTAMAAAGLPVEDSWVSLGSTAPERVRAAAAAMLDAPEPVTALFAGNNRVTVTAVRVLRERPHPVALVGFDDFELADLVHPAITVVAQDAARMGRTAAVQLFRRLDGVDETPRRMEIPTRLIPRGSGEVRPYEG
>NZ_CP047146.1|WP_159504935.1|3083128_3084412_+|aldolase
MGQQETVATSLADTVREGIGAALAAVDADLARRYPGDPGTRQPVHTVYVPGDAFAADTLRSWGEAALAALDEHAPDAGALAAVLGIPDELAGPVHERVRAKLEREPVEDLRIDFEDGYGPRPDAEEDAAAARAAALVAAAYANGTAAPYMGIRMKCMEAAVRDRGIRTLDIFLTGLMEAGGLPEGLVLTLPKVTYAEQVTAMARLLEEFEKARGLESGRIGFEIQIETTQAILGADGRATVARMIEAAEGRATSLHYGTFDYSASCGVSAAYQASDHPAADHAKAVMQVAAAGTGVRVSDGSTNVLPVGPTAQVHDAWRLHYGLTRRALARAYYQGWDMHPGHLPTRYAAVYAFYREGLEKAAARLAAYVAKAGGDVMDEPATAKALSGYLLRGLDCGAVDTDEVARLTGLTRADLDALAGRPAKTA
>NZ_CP047146.1|WP_159504934.1|3082403_3082922_-|DUF664-domain-containing-protein
MTWTAPQRERSSAPAAAGERDMLQGWLDFHRDTLLVKCAGLTPEQLARAGTPPSTLTLLGLVRHLTEVERWWFRRRFAGEPIGDLYCTEDDPDADFNDLDPAAAETDFAAFRTEVAACDAVAAGRGLDETFTATDGRTLNLRWVYVHLIEEYARHNGHADLLRQGIDGATGA
>NZ_CP047146.1|WP_159504933.1|3081950_3082265_-|antibiotic-biosynthesis-monooxygenase
MPVVVATLRTRPGRREDVLAAFRRHTAAVHAEPGCLLYAVHAGDDRVTVVENWADQPALDAHSAGPVLAALGAEIADALDGPMDVAVLEPVPAGAPDKGRLSHP
>NZ_CP047146.1|WP_159504932.1|3080886_3081849_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MAEVLVYVDHVDGAVRKPTLELLTLARRIGEPVAVHLGAGADTAAPVLAEHGAVKVLTADAPEFAEYLVAPKVDALQAAYDAVSPAAVLLPSSAEGKEIGARLAVRIGSGIITDAVDLEAGDEGPVATQSVFAASFTTKSRVSKGTPVITVKPNSAAPEAAPAAGTVEQLAVTIAESSKGTKIVSRTPRESTGRPELTEAAIVVSGGRGVNGAENFPVIEALADSLGAAVGASRAAVDAGWYPHTNQVGQTGKSVSPQLYIAAGISGAIQHRAGMQTSKTIVAINKDSEAPIFDLVDYGVVGDLFDVVPALTEEVKSRKG
>NZ_CP047146.1|WP_159504931.1|3080030_3080819_+|electron-transfer-flavoprotein-subunit-beta
MSLRIVVCVKYVPDATGDRHFAEDLTVDRDDVDGLLSELDEYAVEQALQIKEASDDDAEITVLTVGPEDANDALRKALSMGADKAVHVEDDDLHGTDALGTSLVLAKAIEKTGYDLVVCGMASTDGTMGVLPALLAERLGVPQVTQLSEVSVADGKVTGRRDGDTASEQLEAALPAVVSVTDQSGEARYPSFKGIMAAKKKPVESLDLDDLDIDADEVGLEGAWTKVEDAAERPARTAGTIVTDEGEGAKQLAEFLAGQKFI
>NZ_CP047146.1|WP_159504930.1|3079312_3079819_+|flavin-reductase
MTASPDLGTPRTASPELLRSVFRQHAAGVAVITAHGTRPVGFTATSLTSVAAEPPLLSFGIGTGASSWPAVAEAEHIGVHILGEHQEELAATFARSGADRFGPATSWRTGPEGVPLLDGVLAWLVCRVVARVPAGDHRIVLAEPVVGDPAGPGRPLLYHQGRFNALRD
>NZ_CP047146.1|WP_159504938.1|3090901_3092260_-|M20/M25/M40-family-metallo-hydrolase
MPDSPLAQTVAALQPRARAELAELVAFKSVADFAQFPKSESEAAARWIVDALRAEDFQDLAVLDTPDGTQSVYGFLPGPAGAPTVLLYAHYDVQPPLDEDAWISPPFELTERDGRWYGRGAADCKGGLIMHLTALRALKEHGGIPVNVKVIVEGSEEQGTGGLERYAEAHPELLTADAIIIGDSGNFRAGLPTVTATLRGMTLVRVRVDTLEGNLHSGQFGGAAPDALAALIRILDSLRAEDGSTTVRGLAADAGWEGLQYTEEDFRKDAKVLDGVELIGSGTVADRLWARPAVTVLGIDCPPVVGATPSVHAGARALVSLRVPPGTDAAEATELLTAHLEGAAPWGARVAVEQVGQGQPFRADTSSPAYATMAEALREAYDGQEMQTTGLGGSIPLCNTLAGLYPDSEILLIGLSEPEAQIHAVNESVSPEELERLSLAEALFLRGFAALG
>NZ_CP047146.1|WP_159504939.1|3093932_3094361_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MSQNLKPTRVNSFVGWLARRGVSLAGSADLAVRGRTTGEWRRVPVNPMTLEDGRYLVSARGDSAWVRNMRAAGGGELRVGRRTRAFTAVELPPAETTDLLRAYLARWGWEVKPYFGGATADSTDDELRAVAPHHPVFRITEA
>NZ_CP047146.1|WP_159504940.1|3094530_3095256_+|TetR-family-transcriptional-regulator
MTAIRGARERARSEITEAIKDEARRQLAAEGAAKLSLRAVARELGMVSSALYRYFPSRDDLLTALIVDAYNAVGEAAERAGGALRGPDAEHPAARWSAICAGVRDWALSHPHEYALIYGSPVPGYRAPQATTGPAARVGLALMGVVRDAHAAGALKEPSEPLPGAVAGDALALGAELGVELPPAVLARLVGAWAQLFGLLSFELFGQFNRVVEARTEFFEQAVAGMAREVGLPVPRRGAAG
>NZ_CP047146.1|WP_159504941.1|3096128_3097418_+|sensor-histidine-kinase
MDNARPPWARRCLGTARERWTPTGYPAPGTRAGRRLPWLSTLAVAAVVMVGTNAAAHGQTGRTPIDPLGRALLLFGALLLLFRQRYPRTVALGTAASCAVYLAAGYPYGPVFLTLVLGAFAAIVAGYRAVAWCAVGGVWAGHLLVGHWLYPWLPPYRGPAPWGQELVVTAWVVAVVAVAELVRIRREQLARMRAERAAAERRRADEERLRIARELHDVLAHSISVINVQAGVGLALLDSDPEQARTALTTIKSASKEALGEVRQVLDTLRTPGDAPRSPAPGLDRLPELTEQAGGVGLVVDVTTEGPRTPLPPAADLAAFRIVQEALTNIVRHSGSRTARVLLRRTAGALEIRVDDDGPATSGTGEPAGGNGLVGMRERAAALGGSVEAGPRPGGGFRVRARIPLGGPAGRRRPGAADTVNPGRTEEES
>NZ_CP047146.1|WP_159504942.1|3097414_3098080_+|response-regulator
MIRVLLADDQLLVRAGFKALLDAQHDIEVVAEAGDGRQALAAVREHRPDIVLMDIRMPVVDGLVATRRITGDPALSDVKVVMLTTFELDEYVFEAIRSGASGFLVKDTEPEELLRAVRAVVGGDALLSPGVTRRLIAEFAARSKEPASADALRGLTEREREVMALVGIGLSNEEIARRLVVSPLTAKTHVSRTMVKLGARDRAQLVVLAYESGLVRPGWLG
>NZ_CP047146.1|WP_159504943.1|3098120_3098885_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MEITEFVETLRLDGALLADAADEAGPDAPVPSCPQWRVRDLVVHMGRIHRWATGFVTEPRMRPSRPDEAPELADDELVPWLREGHHRLVLALHGAPRDLETWVFLPAPSPLAFWARRQAHETSVHRADAQQAAGVPLTPLPSRFAADGVDELLTGFHSTARSALHADPPRTLRLRATDTHGADWTVRLTDGPPQTVRTPAADADGAAAGGAADCTVEGPAERLYLALWNRLPWDALKVTGDPAPAELWREHGAP
>NZ_CP047146.1|WP_159509946.1|3099077_3100214_-|MFS-transporter
MDGFLFAGWVVRIPAIKAQTGAGAGALGLALLGVSAGAVAFMMITGRLCRRFGSHAVTTASGAAMALSILLPPLTHSATALGLVLLVFGAAYGSLNVAMNSAAVDLIAALRRPVMSGFHAAFSLGGMLGAGLGGLIAGRLSPAVHLLVLAVVGLVVTAVAGRALREPAAAGRTPLPEGPDTSRSDRSRPAGGSGRARRLVLVFGLIALCTAYGEGAMADWGALHLSQDLAAGPGLAAAGYAVFALAMTAGRLSGTAVVQRFGPARALIAGGSTATAGMLLGALAPTAWAACAGFAVAGLGLANIFPIAIARAGEAGGPDGVAVASTVGYGGMLLGPPAIGFLAEAFGLPVALTTVALLAAVAVAVAYATRGAHRSERG
>NZ_CP047146.1|WP_159504944.1|3100354_3101572_+|ROK-family-protein
MTHTRTTRLERGRSALGPALELVHTGRAPTRAVLTSELGVTRATAGAVAAELEALGLITVDSRPHASAGSQGRPSHRLFVDENGPVVLAAQIHADGYRAALVGLGGRIVATAPGCGTIPADPAHVLAEVVAAGSALLDETGRRCLGAGLAVPSAVAEPDGEALNPLHLAWPSGAPVRELFLRALADAGIPGVTAGIGFTGNDVNLGALAEHRHGAGRGARHLLCVASGHRGVGGALVLDGRLHSGSSGLALEVGHLTVNPEGAPCHCGSRGCLDVEADPLAFLVAAGREPGPEVSLLHQAVELLRNEYADPGVRAAADLLIDRLGLGIAGLVNILNPDRIILGGLHRSLLEADPERLRAVVADRSLWGRSGGVPILPCSLDHNSLVGAAELAWQPVLDDPLVVLD
>NZ_CP047146.1|WP_159504945.1|3102123_3103170_-|CRISPR-associated-endonuclease-Cas1
MTDAEIPELAQIFAPRQIGPAIIVEGFGAKLTVERGQLVIHDGFGPHRRTDKLSRIERRVERIIVTAVNGELTIDAMQWCKDVGISVIMLDPTGDVLMTSGHAYYEGRLHRAQALGSTEAVRYIMVRKITGQYEVSGHPRIKDHLIRLQHDVETIREISAIEAKTSRYYWQSLKGTEVKFRDDVPEHWTTFQTRSSALQSHGKTPRKAVTPFNAMLNLGYSIGYAESRLACHALGLDTELGLLHHPKEAKSHSMALDLVEVARPHVDQMVLDLVAERTFTRKDFYEASDGQCTVGSPLDREIIERARKAVQEPLAEATEDVAHILADSCDTKIKKRTPLTRRTLKATH
>NZ_CP047146.1|WP_159504946.1|3104429_3104855_-|hypothetical-protein
MKFRIKAGAEVDFLTKDELNQVLTDQLGPWRGGVRYKRIPYSGTLPVTVDAPESGFVWSVKLLSVVFDARSPLRVYTQTTDPSSLVGVERGDDVDHVMRWQDNQLTLFGTQPLIVAGSGVAERASGLMYVAEVPVGREWQL

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Crispr_ID: NZ_CP047146_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_9

5605224-5605323

Orphan

Consensus_repeat	Method
TCCGCTGCGCTTTGCCTGCTTCCCACGTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP047146_9

>merge|NZ_CP047146|9|5605224-5605323|CRISPRCasFinder
TCCGCTGCGCTTTGCCTGCTTCCCACGTTGTCGGCTGTCCCGCCGTAGGGGTTTGTCGCCGTTGCGCGGCTCCGCTGCGCTTTGCCTGCTCCCCACGTTG

>NZ_CP047146|9|9|5605224-5605323|CRISPRCasFinder
TCCGCTGCGCTTTGCCTGCTTCCCACGTTG	TCGGCTGTCCCGCCGTAGGGGTTTGTCGCCGTTGCGCGGC
TCCGCTGCGCTTTGCCTGCTCCCCACGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159506681.1\|5608343_5609207_+\|acyl-CoA--acetate/3-ketoacid-CoA-transferase-subunit-alpha	unknown	unknown	gnl\|CDD\|224702
NZ_CP047146.1\|WP_159506675.1\|5603458_5604358_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159506687.1\|5613050_5613737_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP047146.1\|WP_159506674.1\|5602401_5603424_+\|TolB-like-translocation-protein	unknown	unknown	gnl\|CDD\|235083
NZ_CP047146.1\|WP_159506679.1\|5606695_5607484_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236116
NZ_CP047146.1\|WP_159506669.1\|5596019_5597417_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|100115
NZ_CP047146.1\|WP_159506673.1\|5601079_5602399_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340928
NZ_CP047146.1\|WP_159506685.1\|5611778_5612000_+\|DUF1330-domain-containing-protein	unknown	unknown	gnl\|CDD\|377765
NZ_CP047146.1\|WP_159506684.1\|5611336_5611711_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159506683.1\|5609973_5611041_+\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|240081
NZ_CP047146.1\|WP_159506680.1\|5607564_5608341_+\|enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|181174
NZ_CP047146.1\|WP_159506686.1\|5612024_5612867_-\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|379129
NZ_CP047146.1\|WP_159506678.1\|5605782_5606694_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|236099
NZ_CP047146.1\|WP_159506682.1\|5609203_5609977_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|224968
NZ_CP047146.1\|WP_159506676.1\|5604507_5604720_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159506677.1\|5604754_5605219_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380340
NZ_CP047146.1\|WP_159506672.1\|5600180_5601074_+\|acid-phosphatase	unknown	unknown	gnl\|CDD\|309350
NZ_CP047146.1\|WP_159506671.1\|5598924_5599884_+\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|238113
NZ_CP047146.1\|WP_159510181.1\|5594594_5595941_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP047146.1\|WP_159506670.1\|5597575_5598739_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159506681.1\|5608343_5609207_+\|acyl-CoA--acetate/3-ketoacid-CoA-transferase-subunit-alpha	gnl\|CDD\|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	4.6581e-57
NZ_CP047146.1\|WP_159506687.1\|5613050_5613737_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.31383e-05
NZ_CP047146.1\|WP_159506679.1\|5606695_5607484_-\|SDR-family-oxidoreductase	gnl\|CDD\|236116	PRK07856, PRK07856, SDR family oxidoreductase.	1.87617e-129
NZ_CP047146.1\|WP_159506671.1\|5598924_5599884_+\|trypsin-like-serine-protease	gnl\|CDD\|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	6.19313e-06
NZ_CP047146.1\|WP_159506673.1\|5601079_5602399_+\|MFS-transporter	gnl\|CDD\|340928	cd17370, MFS_MJ1317_like, MJ1317 and similar transporters of the Major Facilitator Superfamily. This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.5212e-73
NZ_CP047146.1\|WP_159506685.1\|5611778_5612000_+\|DUF1330-domain-containing-protein	gnl\|CDD\|377765	pfam07045, DUF1330, Domain of unknown function (DUF1330). This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.	1.06587e-17
NZ_CP047146.1\|WP_159506683.1\|5609973_5611041_+\|nitronate-monooxygenase	gnl\|CDD\|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	1.99332e-81
NZ_CP047146.1\|WP_159506680.1\|5607564_5608341_+\|enoyl-CoA-hydratase-family-protein	gnl\|CDD\|181174	PRK07938, PRK07938, enoyl-CoA hydratase family protein.	2.04852e-151
NZ_CP047146.1\|WP_159506686.1\|5612024_5612867_-\|IS5-family-transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	2.62268e-10
NZ_CP047146.1\|WP_159506678.1\|5605782_5606694_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|236099	PRK07791, PRK07791, short chain dehydrogenase; Provisional.	8.88864e-156
NZ_CP047146.1\|WP_159506682.1\|5609203_5609977_+\|CoA-transferase	gnl\|CDD\|224968	COG2057, AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism].	1.97674e-26
NZ_CP047146.1\|WP_159506674.1\|5602401_5603424_+\|TolB-like-translocation-protein	gnl\|CDD\|235083	PRK02889, tolB, Tol-Pal system protein TolB.	3.82212e-05
NZ_CP047146.1\|WP_159506677.1\|5604754_5605219_+\|cupin-domain-containing-protein	gnl\|CDD\|380340	cd02210, cupin_BLR2406-like, Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to BLR2406, a Bradyrhizobium japonicum protein of unknown function with a cupin beta barrel domain. Proteins in this subfamily appear to align closest to RmlC carbohydrate epimerase which is involved in dTDP-L-rhamnose production, and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.8446e-36
NZ_CP047146.1\|WP_159506672.1\|5600180_5601074_+\|acid-phosphatase	gnl\|CDD\|309350	pfam04185, Phosphoesterase, Phosphoesterase family. This family includes both bacterial phospholipase C enzymes EC:3.1.4.3, but also eukaryotic acid phosphatases EC:3.1.3.2.	2.07467e-35
NZ_CP047146.1\|WP_159506669.1\|5596019_5597417_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|100115	cd05804, StaR_like, StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been speculated that StaR could be a flavoprotein hydroxylating a tyrosine sidechain. Some family members have been annotated as proteins containing tetratricopeptide (TPR) repeats, which may at least indicate mostly alpha-helical secondary structure.	2.37606e-96
NZ_CP047146.1\|WP_159510181.1\|5594594_5595941_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.84764e-49
NZ_CP047146.1\|WP_159506670.1\|5597575_5598739_+\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	4.37117e-128

>NZ_CP047146.1|WP_159506677.1|5604754_5605219_+|cupin-domain-containing-protein
MGYDAFHPDLDGSGADGPAPLRARLHHIRADALDGDTAQTDGMRRFAAISGGAVGSERIWMGQTHVAPGTASSNHHHGASETAIYVVKGHPEFVFAEDTGGAREEVRLRTDPGDYVFVPPYVPHREENPSPDEEAVVVIARSTQEAIVVNLPGL
>NZ_CP047146.1|WP_159506676.1|5604507_5604720_+|hypothetical-protein
MSRSLVLALVSGLLLAATGCVALARPPGQGAGSRHRTVAPAQLSRTLLTWLERPGAGTAPKRRWEHAMDG
>NZ_CP047146.1|WP_159506675.1|5603458_5604358_-|hypothetical-protein
MARWPAVLFALLAAACNALSTVLQRRAARSVPVCGRLRLGLIADLLHRAVWLAGMAMVLPAACFQALALSLGALSVVQPIFVLELPLALLIGRLLLGGRISRPGWAGVGLLVVGLGTALAAAAPSVGRDHAPLSRWVPALVVCATVIAATVGAGLRRGAGSVRAAGFGAATAVAYALTAALLKDATHVWQAAGPAAFFLSWQTYGFALAGALALFLMENAMQSGPLTASQPVLTLGDALVSLSLGVTLFDEQVRVGWWLLLEGLGVGLVLWGAVMLSRVALARDLAAGQAAGPPPGSPA
>NZ_CP047146.1|WP_159506674.1|5602401_5603424_+|TolB-like-translocation-protein
MTQNSRLAVLLAAVLLLGAVGAVAVLRAADRSGSRDRQQAGGPAVHAGSVSLRPGTGRRLLVRNLAWGPHRDEIASVPADRPQGPRTASGVKCLRFHAAAGTAVCLQAEHGALEDTYRAVVLDAHLRELHRFPAAGIPTRARVSPSGHRVAWTVFVSGDSYAGTDFSTRTAIVDTRTWAIDDNLERYAVVKDGRPYHASDINVWGVTFADDTRFYATLATGGQTYLVQGDAAARTLTTLHRNVECPSLSPDGTRIAYKKRAPGASPDAPWRLYVLDLRTMAETATAEHRNIDDQALWADGANLVYALPGDYGSDLWTVPANGSGAARRMMTSAVAPAYVR
>NZ_CP047146.1|WP_159506673.1|5601079_5602399_+|MFS-transporter
MYLADSRNGTTREPSSTAAAAPGSIRPGRRAAVPGTVLALGAVSLITDVSAEMITAVLPLYVVTALGLSPLGFGLLDGINNGVGALVRLAGGHLADGGGRRHKVVAGLGYGLSALCKPLLLVAHGLPVISAVLAADRTGKGLRTAPRDAMISLATRPEHRGRAFGVHRAMDTTGALLGPLAAFAVLRATVDGYDAVFTVSGCVAVLGVLVLVLFVPGRAGGADARPAAARPALRDSLALLRRPTLRRLTLCAALLGLTTVSDSFLYLLLQRELGVPAHLFPLLPLGTAAVFLLLAVPLGALADRIGRRRLFLAGHGALLLAYGLVLSPLDGAPAVVAVLVLHGAFYAATDGVLAAATAGAVPARHQGAGQALVGTGQALARFVCSLAFGAAWSLWDGRAALAVTAAGLAVGAVVAARVLRTVEGTPEENDDDRRISDEV
>NZ_CP047146.1|WP_159506672.1|5600180_5601074_+|acid-phosphatase
MTAAKARKRTRRTLTALAGAMAVTATSAALWATTGSTASAQTAGLPSPDHVVVVVMENHAYGQVIGDSSAPYINSLKAGGADLTQSYALTHPSEPNYYMLFSGDNQGRTDDSCVDVGSMSAPNLASELIAAGQSWASYNESLPSQGSTTCSSGDYAQKHNPWFGFSNVPADTAMTMDQFPSDYSTLPKVSFVIPNLCNDMHDCSVSTGDSWLKDNLSAYADWAKSHNSILAITFDEDNRLSGNRIPTLLYGQHVAPGSTSDTQYNHYNVLRTLEDLAGLTTHAGNAASASDISDIWN
>NZ_CP047146.1|WP_159506671.1|5598924_5599884_+|trypsin-like-serine-protease
MGRPLPAPGRLARLLLAALLLVLPLTALPAPLAHAAGDPGSPASTDDRYWTAHRMEAAEPVATKGSSPTPKAAGTPVPPSHPFDGLPQVGTFFWTDGHNIGRFCGGTVVRSPHRNLVVTAGHCLLSPDPKKYLSFVPQYHDGLKPHGIYPVERIYLDQHLYDLGTDGGARWDYAVVQVGPREDGAEVQEVTGGFDLLPYPGYVHHDVRLIGYPGSSDATYPKPLDCSSATHRYTSTDPAAPGDFLEIPCAGYIGGTSGGPFLVPDFRGYALIGVIGGYHTGGDTPDISYSAYFTFDTALLYLHAVRGDTPAAPRPKPTA
>NZ_CP047146.1|WP_159506670.1|5597575_5598739_+|CoA-transferase
MLPLDGITVVSVEQAVAAPFATRQLADLGARVIKVERPGAGDFARSYDETVRGMSSHFVWLNRNKESIALDMKDAADAEVLRRLVARADVFVQNLAPGAAERLGLDAATLCQGDPRLVVCGISGYGSGGPYEHKKAYDLLVQCEAGVMSLTGTEEAPAKIGIAVADIAAGMYAYSGILTALYERERTGRGGSFEVSMLEALGEWMGYPHYFTRYGGSQPPRSGAEHAAIAPYGPYRAAAGAQVFLSIQNEREWAEFCTRVLDLPELAADPRFARNSVRVANREVLRERIEERFGTMTAEEVEQRLEAARIAHGRLRDVAGFAAHPQLAARDRWRTVDSPVGPLDALLPPVTVAGREPRMDRVPALDEDRARILAELHGTARETGGER
>NZ_CP047146.1|WP_159506669.1|5596019_5597417_-|tetratricopeptide-repeat-protein
MTVDRHGHAMTDTGAEALRHYEQALDDLLFFRPAITDTTLALLAAAPRAPMGQALAAYLGVLGTEEKGAAEAHQRFSRFRAGLDADRLTPRERMHIAAATAWLDGDYRTAGRVLGEISVAHPRDLLALFAGHHHDFLTGDAQRLRDRVGGALDAWDEDDPHRAPLLGMYAFGLEETGHYEHAEQVGRAALDRHPHDVWAIHGVVHTYEMRGRFADGIRFLDARTAHWSSGTLLTVHNWWHYALYALESGDTARVLGIYDSALHHDRSAGVAMELLDAAALLWRLYLAEDDQSTRWTALADAWERRADGPHYAFNDAHAVMAYVGAGRIDRARCLVRDRESWLAAEPAGANRAMTAEIGLPVCRALIAYGCRDYAGAADLLLPIRHRVHEFGGSHAQRDAVQRTLVEAALRADRPGLARTLLSERIQLRPICPYNWSAKARLEDRLGAPDRAEAARKRAAAQAVTA
>NZ_CP047146.1|WP_159510181.1|5594594_5595941_+|MFS-transporter
MLVALDGTVLMVAQPGLRRDLGASVAQVQWTSTGYLVAVASLLVIAGRLGDRYGHRRLLLAGVAGFGLASGGIALAPGIGWVVGLRVAQGVFGALLQPATLALLRLAYPADRLGTAVAVRTAAIGVAAAAGPVLGGVLVAQWGWRSVFWVNVPVALLLALLVLAVRVPAAAPAGDGRLDLVGAGLLALALGVCVGTLSGVPERGWASVPTVCGLTAAAGLAGALVVQERRSAQPIVPSVVAGSRSVTASMAMLLLVSGGMFGALFAATFLLQDVAGLGPFASAVRVLPLTALMVLGAPVAGAALRRYGPRRVALAGVALVVLGLVGLSGLGTHCAWAVTGAAFAGLGAGFATVMVTATGTVVGDAPPGYAGVVGGLKQTAVNVGPAFGIAVAASMMFLKSAAGGPGSASDGSAAATGGTLLVLAAVAALALLPAGLLPGRPVPAAVGG
>NZ_CP047146.1|WP_159506678.1|5605782_5606694_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTGICTGRVAAVTGAGRGLGRAHALALAAEGARVVVNDLGVAADGAGASAGPAQQVVEEIRARGGEAVAHTGDITTGEGAASLIAAALDSFGRLDSLVNNAGFLRDRMLVNLDEDDWDAVLRVHLKGHFLPLRHAAAHWRAEAKAGRTPDARIVNTSSGAGLLGSVGQGNYSAAKAGILGLTLVAAAELGRYGVQVNAIAPAARTRMTEQTFADSMAAPAEGEFDAMAPENVSPLVVWLSAADSAHVTGRVFEAEAGRITVMEGWRPGPTADKGARWTPAEAGETARKLLAAAEPAQAVYGAP
>NZ_CP047146.1|WP_159506679.1|5606695_5607484_-|SDR-family-oxidoreductase
MSLTLDLTGQVAVVTGGTRGVGAGIARAFLQAGAEVVVCARRPPDAPVTADGRTARFRPLDLRDPPAVREFFARVAAEHGRLDCLVNNAGGTPYRLLGETGAERHARVVELNLTAPLTASLAAYEVMRGQPHGGSVLMIGSVSGTRPSPGTAAYGAAKAGLDNLARSMAVEWAPAVRVNTVVLGMVRTELAALHYGDAAGLTAVGATVPLGRLAEPAEIGDACVFLASDRARYVSGASLLVHGGGERPAFLDAATVNHPKEP
>NZ_CP047146.1|WP_159506680.1|5607564_5608341_+|enoyl-CoA-hydratase-family-protein
MGVSTSGPDRGIAVVTVDFPPVNALPVQGWYDLADAVRAAGRDPDVRCVVLAAAGRGFNAGVDIKEMQRDTAAGGHTALIGANRGCAEAFAAVYECEVPVVAAVQGFCLGGGIGLAGNADAVVASEDATFGLPELDRGALGAATHLARLVPQHLMRALYYTSRTATAAELHAHGSVWKVVPRDELLESAVELAREIARKDGSLIRLAKAAINGIDPVDVRRSYRFEQGFTFEANLSGVADRVRDTFGRAPEAADSEED
>NZ_CP047146.1|WP_159506681.1|5608343_5609207_+|acyl-CoA--acetate/3-ketoacid-CoA-transferase-subunit-alpha
MTDKTMTPDDVIARLRSGMTLGIGGWGSRRKPMTLVRALLRSEITDLTVVSYGGPDVGLLAAAGKIRKLVAPFATLDSIPLEPHFRTARQAGAFALAEVDEAMFMWGLHAAANRLPFLPVRAGLGSDVMRVNPGLKTVTSPYEDGETFVAMPALRMDAALVHLNRADRLGNGQYLGPDPYFDDLFCEAADAAYVSCERLVDTGGFRDAAPQTLLVKRHAVTGVVETPHGAHFTSCVPDYGRDEPFQKLYATAPWPEFAARFLHGDEKTYQSAVRTWHEELTAKEEQK
>NZ_CP047146.1|WP_159506682.1|5609203_5609977_+|CoA-transferase
MTTTSGPAANATATATATRAEYCVIACADAWRDNGEVLASPMGTIPSIGARLAKRTFSPDLLLTDGEAMLVGLDGEPEGWLPYRRHLAMVTGGRRHVMMGASQLDRFGNQNISCIGDWQRPARQLLGVRGAPVNTLNHPVSYWIPRHSPRVFVERVDMISGVGYDSAAAAGPSATRYHRIPRVVSDLGVLDFATPDHTMRLASLHPGVTAEEVRQATGFALTVPEQIPCTREPTGDELRLIREVIDPQGLRDREVPS
>NZ_CP047146.1|WP_159506683.1|5609973_5611041_+|nitronate-monooxygenase
MSAGTSPALATPLTELVGVRHPIVQTGMGWVAGPRLVSAAADAGALGILASATMTPDQLRSAIREVRSRTERPFGVNLRADAGDAAERVGIIVAEGVRVASFALAPSKELIARLKDAGVVVIPSIGARRHAEKVAAWGADAVVVQGGEGGGHTGDVATTVLLPQVVDAVDIPVIAAGGFFDGRGLVAALAYGAAGIAMGTRFLLTSDSTVPRAVQTRYLEAAVKDVTVTTKVDGLPHRMLRSELVESLERSGRTAALLTAVRHAAAFRKLSGLSWTRMVRDGLAMKHGRQLTWSQVLLAANTPMLLKASMVDGRTDLGVMAAGQVAGLIEDLPSCAELIDRIMTEAHGTLADLPR
>NZ_CP047146.1|WP_159506684.1|5611336_5611711_+|hypothetical-protein
MPSDGLQAGRTTDIRYTATGDIHQTGTGPLLQAVAGSLFAAATATGGIAVLLLAFRRVNPAQTDRRGPARQVGAFLVQLPVRTPAARQWAMSGPGFARGRLPTRTTGTMQRQQPRGRGGVRPPS
>NZ_CP047146.1|WP_159506685.1|5611778_5612000_+|DUF1330-domain-containing-protein
MAKGCKGYLVGTYRSVRDPEKLAAYGELAKPALEAAGGWILARGGRVTAFESGLPERTVLVEFPSYDAAVAAY
>NZ_CP047146.1|WP_159506686.1|5612024_5612867_-|IS5-family-transposase
MPVLPSWLTEPLWAQFSALLPQRPLHHPAHPLRCHRPRISDRIVFDKLLQLLRFGCPYEAIADTTCSASTIRSRRDEWIRLGIFSQLKRIALDSYDRIIGLMLDQIAIDGSLTKAPGGGEVAGRSPVDRGKQGLKRSGMTDGYGIPLGRVLAGANCHDSPLLAPTLDHLAELGPLPDYITVHLDAGYDSHKTRALLDERGLHGRIAHKGEKAPIQSSQRWHVERTHAWQNAFHRLSRCYERRAVVIDAFFDLADTIITVRSLIRRSWTTHRWDNRPRRCP
>NZ_CP047146.1|WP_159506687.1|5613050_5613737_+|TetR-family-transcriptional-regulator
MAVGKGRAVRLSPELIVEAAVRIAARAEPDGLTGRALGEELGVDRSAVWRHFADRDALLLAVGDRLLAMAVERVPDGLGPREVLQELARSLVEVFEAHPYVGAAVACRTTRGPGEFAAMETMLAALEEIGLDEGSVARYQRMLADTVLAYAGMRAGYAALPQEVRAADEHAWAGAYATISPERYPAITTHLPQLAAQDDEAVFQTLMEAFWLAVDATARTTPKDDADV

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Crispr_ID: NZ_CP047146_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_10

6544171-6544402

Orphan

Consensus_repeat	Method
GGAGGCGTCGCCGTCAGGGGCCGGG	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP047146_10

>merge|NZ_CP047146|10|6544171-6544402|CRISPRCasFinder
GGCGGCCTTGGCCTTACGGGCCGAGAGTTTGGACTTACGGGCGGAGGCGTCGCCGTCAGGGGCCGGGAGCTTGGCCATACGGGCGGGGAGTGTGGCCGTACGGGCGGCGTCGCCGTCAGGGGCCGGGGACGCCGCCTCCGCGGCGCGGGTTTCGCCTTCTGGGACGGGGCCGCCGCCACCACGTGCCGGGGCGTCGTCCGCGGCGGCGGGCGCGTCGCCCTCGGGGGTCGCG

>NZ_CP047146|10|10|6544171-6544402|CRISPRCasFinder
GGCGGCCTTGGCCTTACGGGCCGAG	AGTTTGGACTTACGGGC
GGAGGCGTCGCCGTCAGGGGCCGGG	AGCTTGGCCATACGGGCGGGGAGTGTGGCCGTACG
GGCGGCGTCGCCGTCAGGGGCCGGG	GACGCCGCCTCCGCGGC
GCGGGTTTCGCCTTCTGGGACGGGG	CCGCCGCCACCACGTGCCGGGGCGTCGTCCGCGGCGGC
GGGCGCGTCGCCCTCGGGGGTCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159507339.1\|6534365_6535187_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187632
NZ_CP047146.1\|WP_159507356.1\|6554652_6557007_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP047146.1\|WP_159507343.1\|6539541_6540426_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP047146.1\|WP_159507348.1\|6545247_6545679_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP047146.1\|WP_159507345.1\|6541114_6542437_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|99735
NZ_CP047146.1\|WP_159507357.1\|6556972_6558016_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|236599
NZ_CP047146.1\|WP_159507352.1\|6549583_6550324_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159507341.1\|6536741_6537758_-\|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|163554
NZ_CP047146.1\|WP_159507337.1\|6533147_6533675_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159507355.1\|6553594_6554410_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213022
NZ_CP047146.1\|WP_159507350.1\|6547170_6547722_+\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|183137
NZ_CP047146.1\|WP_159507346.1\|6542433_6543276_-\|acyltransferase	unknown	unknown	gnl\|CDD\|143592
NZ_CP047146.1\|WP_159507338.1\|6533846_6534284_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP047146.1\|WP_159507349.1\|6545776_6547135_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP047146.1\|WP_159507353.1\|6550375_6551476_+\|ionic-transporter-y4hA	unknown	unknown	gnl\|CDD\|223464
NZ_CP047146.1\|WP_159507351.1\|6547705_6549187_-\|amidase	unknown	unknown	gnl\|CDD\|235686
NZ_CP047146.1\|WP_159507344.1\|6540589_6540916_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159507354.1\|6551465_6553418_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP047146.1\|WP_159507340.1\|6535340_6536693_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223717
NZ_CP047146.1\|WP_159507342.1\|6537809_6539216_-\|dihydropyrimidinase	unknown	unknown	gnl\|CDD\|236240

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159507339.1\|6534365_6535187_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187632	cd05374, 17beta-HSD-like_SDR_c, 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. 17beta-hydroxysteroid dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	8.08992e-77
NZ_CP047146.1\|WP_159507356.1\|6554652_6557007_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	6.75778e-84
NZ_CP047146.1\|WP_159507343.1\|6539541_6540426_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	6.57461e-09
NZ_CP047146.1\|WP_159507348.1\|6545247_6545679_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.93169e-16
NZ_CP047146.1\|WP_159507345.1\|6541114_6542437_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|99735	cd00610, OAT_like, Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, alanine-glyoxylate aminotransferase, dialkylglycine decarboxylase, 4-aminobutyrate aminotransferase, beta-alanine-pyruvate aminotransferase, adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and glutamate-1-semialdehyde 2,1-aminomutase. All the enzymes belonging to this family act on basic amino acids and their derivatives are involved in transamination or decarboxylation.	8.03463e-131
NZ_CP047146.1\|WP_159507357.1\|6556972_6558016_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|236599	PRK09632, PRK09632, ATP-dependent DNA ligase; Reviewed.	1.02572e-91
NZ_CP047146.1\|WP_159507341.1\|6536741_6537758_-\|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|163554	TIGR03842, F420_CPS_4043, F420-dependent oxidoreductase, CPS_4043 family. This model represents a family of putative F420-dependent oxidoreductases, fairly closely related to 5,10-methylenetetrahydromethanopterin reductase (mer, TIGR03555), both within the bacterial luciferase-like monoxygenase (LLM) family. A fairly deep split (to about 40 % sequence identity) in the present family separates a strictly Actinobacterial clade from an alpha/beta/gamma-proteobacterial clade, in which the member is often the only apparent F420-dependent LLM family member. The specific function, and whether Actinobacterial and Proteobacterial clades differ in function, are unknown. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP047146.1\|WP_159507342.1\|6537809_6539216_-\|dihydropyrimidinase	gnl\|CDD\|236240	PRK08323, PRK08323, phenylhydantoinase; Validated.	0
NZ_CP047146.1\|WP_159507355.1\|6553594_6554410_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	2.12588e-76
NZ_CP047146.1\|WP_159507350.1\|6547170_6547722_+\|isochorismatase-family-protein	gnl\|CDD\|183137	PRK11440, PRK11440, putative hydrolase; Provisional.	8.19978e-58
NZ_CP047146.1\|WP_159507346.1\|6542433_6543276_-\|acyltransferase	gnl\|CDD\|143592	cd07568, ML_beta-AS_like, mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases). This family includes mammalian-like beta-AS (EC 3.5.1.6, also known as beta-ureidopropionase or N-carbamoyl-beta-alanine amidohydrolase). This enzyme catalyzes the third and final step in the catabolic pyrimidine catabolic pathway responsible for the degradation of uracil and thymine, the hydrolysis of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyrate to the beta-amino acids, beta-alanine and beta-aminoisobutyrate respectively. This family belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 5. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Beta-ASs from this subgroup are found in various oligomeric states, dimer (human), hexamer (calf liver), decamer (Arabidopsis and Zea mays), and in the case of Drosophila melanogaster beta-AS, as a homooctamer assembled as a left-handed helical turn, with the possibility of higher order oligomers formed by adding dimers at either end. Rat beta-AS changes its oligomeric state (hexamer, trimer, dodecamer) in response to allosteric effectors. Eukaryotic Saccharomyces kluyveri beta-AS belongs to a different superfamily.	3.77477e-152
NZ_CP047146.1\|WP_159507338.1\|6533846_6534284_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	7.30806e-18
NZ_CP047146.1\|WP_159507349.1\|6545776_6547135_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.8382e-33
NZ_CP047146.1\|WP_159507353.1\|6550375_6551476_+\|ionic-transporter-y4hA	gnl\|CDD\|223464	COG0387, ChaA, Ca2+/H+ antiporter [Inorganic ion transport and metabolism].	1.85765e-72
NZ_CP047146.1\|WP_159507351.1\|6547705_6549187_-\|amidase	gnl\|CDD\|235686	PRK06061, PRK06061, amidase; Provisional.	0
NZ_CP047146.1\|WP_159507354.1\|6551465_6553418_-\|amino-acid-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	8.79906e-23
NZ_CP047146.1\|WP_159507340.1\|6535340_6536693_+\|hypothetical-protein	gnl\|CDD\|223717	COG0644, FixC, Dehydrogenases (flavoproteins) [Energy production and conversion].	7.09224e-16

>NZ_CP047146.1|WP_159507346.1|6542433_6543276_-|acyltransferase
MADVVRAALVQATWTGDTESMIAKHEEYARAAAAQGAKVIGFQEVFNAPYFCQVQEPEHYRWAEPVPDGPTVRRMQQLARETGMVIVVPVFEVEQSGFYYNTAAVIDADGTVLGSYRKHHIPQVKGFWEKYYFKPGNAGWPVFDTAVGKVGVYICYDRHFPEGWRQLGLNGAQLVYNPSATSRGLSAYLWKLEQPAAAVANEYFIAAINRVGVEEYGDNDFYGTSYFVDPRGRFVGDVASDTKEELVVRDLDFGMIDEVRQQWAFYRDRRPDAYDGLVKP
>NZ_CP047146.1|WP_159507345.1|6541114_6542437_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MNQHSHDPAGLRARHRAVLPEWLALYYERPLELTHGEGRHVWDAEGNRYLDFFGGILTTMTAHALPEVTKAVGEQAGRILHTSTLYLSRPMVELAERIAALSGIPDARVFFTTSGTEATDTALLLATSYRRSNQILAMRNSYHGRSFSAVGITGNQSWSPTSLSPLQTLYVHGGVRSRGPFAELSDADYIAACVADLTDLLQQTAGGVAALIAEPVQGVGGFTAPPDGLYAAFREVLAREGILWISDEVQTGWGRTGDHFWGWQAHAENGPPDLLTFAKGIGNGMSIGGVVARAEVMNSLPANSISTFGGSPVTMAAGLANLGYLLEHDLQGNARRVGGLLIERLRAVAAGLDVVREVRGRGLMIGVELVRPGTDEPSPEAATLVLEAARERGLLVGKGGQGGAVLRIAPPMSLTVAEAEEGAEMLADALRWAQERLRDG
>NZ_CP047146.1|WP_159507344.1|6540589_6540916_+|hypothetical-protein
MKRPPTTRLRWGVALVNGVALVGTWTAAAEEAPSGTGPTGAHRAAGHRAAPLWRADPAKGSASFEGVEPKPGSVTVVDDPAGRLGGPVAAQGLRLGRLDPAALAARPR
>NZ_CP047146.1|WP_159507343.1|6539541_6540426_+|ABC-transporter-substrate-binding-protein
MEQSTPWEFSDDRGRLVVAGNRPERIVAYIQAGATLWDHGIRPVGIFGSQHDGAAADPAKGGELPLAEIPYLGSGAALHPDTLLEARPDLVVAVTYDSEQVYGLEAKTALELETHVPVATVAVGPGRGLAEVRERFAALAGSLGRGEPLTMARELDAAEDVLRQASGGSVRPRVVALSPAGPERVHLARPGAWPDLRALAEHGVELPEPAAGSGANWATVGWAEAAALAPDVVLIDVRVNAARVEALRTDEHWRAIEGRARLLPWNPEAPASRRAHTRFFTDVAEAVRGAAART
>NZ_CP047146.1|WP_159507342.1|6537809_6539216_-|dihydropyrimidinase
MSRTVIKGGLVITAADETHADVLVEDGRIAALAASGSWAAAGWAESADRTLDATGRYVIPGGVDAHTHMELPFGGTAASDTFETGTRAAAWGGTTTIVDFAVQSRGNSLRAGLDQWHAKSDAQCAIDYAFHMILSDVNEHTLKEMDLLVSEGVTSFKLFTAYPGVFYSDDGQILRAMQRAAGNGGLVMMHAENGLAIDVLVEQALAAGRTDPRYHGEVRHVLLEAEATHRTIQLARVAGAPLYVVHVSAEQAVDEIARARRLGLNVFGETCPQYLFLSTDNLAEPDFEGAKYVCSTPLRPREHQAALWRGLRTNDLQVVSTDHCPFCFRGQKELGRGDFSKIPNGMPGVENRMDLLHQAVVDGHISRRRWIEIACATPARMFGLYPKKGTIAPGADADLVLYDPTAEQTVSAKTHHMNVDYSAYEGRRLTGRVETVLSRGELVLDKREFTGRAGHGQYIPRGTCQYLL
>NZ_CP047146.1|WP_159507341.1|6536741_6537758_-|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase
MDFGVVLQADPPASAVVELMRRAERNGFRYGWTFDSAVLWQEPFVIYSQILEHTTELTVGPMVTNPGTRTWEVTASTFATLNDMFGNRTVCGIGRGDSAMRVAGRKPNTLATLGEAIHVIRDLAEGREAEVEGRRLRIPWVRNGHLPVWMAAYGPKALALTGRQADGFILQLADPYLTQWMVKAVRDAATAAGRDPSSVKICVAAPAYLTDDASPAALAHAREQCRWFGGMVGNHVADLVARYGEHSGAVPETLTAYIKERHGYDYAHHGRAGNPDTAFVPDEIVDRFCLIGTEAQHIDKLRELKELGVDQFALYAMHDAREKVIDGYGAGVIPALRH
>NZ_CP047146.1|WP_159507340.1|6535340_6536693_+|hypothetical-protein
MPMGTDVRHAVVIGAGMAGLAAARVLADGFEAVTVIERDTLPSASEPRVGVPQGHHVHGLLALGAEVFEGYFPGLRAELEEAGAPVWDWGEDLCAVLPNGTPPPTPMGMPIQTFSRPLLEHVLRRRVSALEPVTLRDGLTVTGLRTAGPGRVTGVRVKNGDGEDEIVADLVVDASGRSSHLPQWLAALGLPSPRTTTVDAQVGYASRTYSYPEGQSPPSWKGVLEPLRAPDFHKGSYAIQIENNALHVTLHGAGGIQLPRGDDDFLAFTKTLRGPIADTIASLTPVSPVRRYARTVNRKTAYHRLARWPDGLIALGDSVCTFNPAYGQGMTVAALEARLLEQMLRGRRTRAPFDGQGFQRRLARVTAFSWLMATIPDRAWEQSRPALPVKAGNWFMNRMIDTVPHDPRVYTTFSGLFHMLAGPLALADPRLLSRVLVGPRPGGSLHAATP
>NZ_CP047146.1|WP_159507339.1|6534365_6535187_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTTKTVLITGTSSGIGLAAAVTAARSGWHVIATMRDTAKAGALLAAAEEAGVAVDVRALDVTDPASVEACLAGLDRLDALVNNAGAGHVGTLEQESVEDVRAVMEVNFFGVLHVTKAALPLLRASKGRVLTVTSVGGVIGQPFNEAYCAAKFAVEGFMESLAPVAATTGVHVSVVEPGAVASEFVSNVGLPDNALQQAGPYAPALSAYLDRTRGAFAHAQTPQDVATQIVDLLAAERPAFRVLTSDTARAFAATKLKDLDGSAVQTLTSGWVV
>NZ_CP047146.1|WP_159507338.1|6533846_6534284_-|MarR-family-transcriptional-regulator
MGTLDAMSNPPDELSREIVGLFAAINRRYGQESEAAATPHDLTPLQAKALLAAEGPVPMRRIAERLHAEPSNVTVIIDRLESSGLVERSPDPGDRRVKRVAATAAGRTVAADLRARMPFAADPLAPLTAQQRETLRELLQLILEA
>NZ_CP047146.1|WP_159507337.1|6533147_6533675_+|hypothetical-protein
MADGANTDDRAGDEGRQRPEQPGGNYAGAIYGSLLAASVVAGTATFGPFPRLGLLLLLLITGLVFWAAHVYALLVGDLLSYRHLTWAAIRHVAGHEWPIVQAAVLPAVAVAVSPLLRLDLEGTAWFALSVAVAEQIGWASTAAVRAGASLRVVVVSGAVNLVLGLVIVVAKAQLH
>NZ_CP047146.1|WP_159507348.1|6545247_6545679_+|MarR-family-transcriptional-regulator
MPNKDQERLATDLGATVSLLMRQLRAASPQGALTPTQRAVIALIDSEGPSTIAALARAELVRPQSMRVTVGALEDSGILARSPHPTDGRQVVFSLTDHGHRVLAEVRQAKNNWLAVAIADRLSADEQQTLEAATALIRRLIRP
>NZ_CP047146.1|WP_159507349.1|6545776_6547135_+|MFS-transporter
MTPLLLGSLLNPVNSTMIATALVAIGQDFRVGAADTAWLISAMYLASAVGQPSLGRLADRVGPRRVFAAGAVAVVAAGLIGALAPTFTLLIVSRVVLGIGTAAAYPAAMAMLRAESRRVGRPAPRSVLGRISLAALASAAVGPTLGGLLAATWGWRAVFAVNVPLALLALAGALAWLPPDRETRHTARAADGTGSDGGSLDPLGIALFAGALTCAMFFLLRLDAPRWPLLAPTAALTAALVWWELRHPEPFLDLRMLARNRALVLTYLRHGLAYLVIYCVLYGYSQWLEQAHGFTSFHAGLIMLPMSGAAAVCSLAGARTKGIRAPLTVAAAFLALGSTVLVMLDGGSPVAVLLVAGALFGIPQGLASTGNQAAVYAQAPADGVGAAAGLQRTAQYLGAISSSSLIGLLYGQRATDSGLHGIALAGAVLAVLLLALTLADRSLRTGPTRATT
>NZ_CP047146.1|WP_159507350.1|6547170_6547722_+|isochorismatase-family-protein
MPVTTLDPRTALVLIDLQKGIVALPTVHPADEIVARGARLAAAFRERGLPVVLVNVTGGAPGRTESAAGGRTPPADWAELVEEIDRQPGDVTVTKQQWGAFHGTALDLELRRRGVTQIVFAGIATSIGVESSARAAHEHGYHVTVATDAVTDLDEAAHHNSLEKIFPRLGETGTTDAILTLLG
>NZ_CP047146.1|WP_159507351.1|6547705_6549187_-|amidase
MSVDESQDRPRRPERRIRRTAGELDGQWEGLAEQAQALAGGQVAATALVQRCLERIAATQDTVNAFRRVRAEAALDEAAAADRRLAAGERLPLLGVPVAVKDDTDVAGEPTAFGCAGLFPPKERDSEVVRRLRAAGAVIVGKTNACELGQWPFTEGPAFGDTRNPWSLAHTPGGSSGGSAAAVAAGLVPAALGTDGAGSVRIPAAWSHLVGIKPQRGRISTWPEAEAFQGITGIGPLARTVEDAALLLDVASGNHAGDLHRPPAIAAREAAGRDPGRLRIALSWKAAATFTRKPLHPDVRAAVTSLAHTLAGLGHFVEEAEPDYGLVGLAFVPRATAGVGEWAARVPDPRLLDRRTREAARLGRLLGGPVLRRARAAESRQQQRIGALFGPYDVLLTPTTATPPPRVGTLAKLSGWRTDRAMIAACPYAWPWNVLGWPGVSVPAGFSADGLPLGGQLLGPAHAEPRLISLAAQLQDALRWQDRRPGDGLSPGA
>NZ_CP047146.1|WP_159507352.1|6549583_6550324_+|hypothetical-protein
MDDTLLLTATVALLVGLGAGWAVQSALTRRKLVREQSFFGLPEGSECVLVTHRDSSSAQWSIPRHDALALLGLASVVENCGAHPEVAPHDTGLQGFGARTEFCVGDPTAHRRLAAHMSNLLPGVTVHPGDAAGAGRGTFTVGGTAYRMEPGAVEYVLLARLTAGEGDRPVFLAAGQRPVTHRAAVRHLVRNRARLARKYGAGGQFCLLLKVVNSQAYGPDVVELVADVTKAAIAPAELKGQHRAAA
>NZ_CP047146.1|WP_159507353.1|6550375_6551476_+|ionic-transporter-y4hA
MIARLRSAVPHWAGVLPVAAVVLLALTWGRSLSVTLVVLVSPFLAGAVLAAVHHAEVIAHRVGEPFGSLVLAVAVTVIEVALIVTLMVDGGDKSAALARDTVFAAVMITCNGIVGLSLLVGSLRRKVAVFNSEGTGAALATVATVAGLSLVLPTFTTTAPGPRFSPPQLVFAALAALALYGLFVATQTVRHRDYFLPVTTAGEVIDTEDHAEPPTARGALLSLGLLALALIAVVGLAKAESPAIESAVIAAGLPSSVVGIVIALLVLLPETIAAARAARRDRVQTSLNLGLGSAMASIGLTIPAVALASVWLPGPLVLGLGASHMVLLALTVVVGTLTVVPGRATPLQAGVHLALLAAYIVLAVSP
>NZ_CP047146.1|WP_159507354.1|6551465_6553418_-|amino-acid-permease
MRHLIRPKRIMVGRPLDSARLGETLLPKRLALPVFCSDPLSSVAYATEELLLVVGLGGVALLHLAWYAAAAIVVVLAVVVASYRQTCYAYPGGGGAYVVSARNLGRNAALTAASALLVDYVLTVAVSVVSGVAAITSAIPELGGHDVALSVGFVSLLALMNLRGVRESGRIFAVPTYGFVCSVYLMFAFAAVRMATGATPRAESADLPLHTASAYSGAALVLLGMRAFASGCTALTGVEAISNGVPAFRRPKSRNAATTLLVMGFFSITMFAGITFLAMVYQVHVAADPTVLGLPPHTPTATALAQIGRASFGGAHSLFYLLQAFTAGVLILAANTAFNGFPMLASILAADSYLPRQLHNRGDRLVFSNGVILLALAAIGLIVLFRAELTRLIQLYIIGVFVSFTLSQTGMVRHWRGLLAGPGLRRPVRLRYRRSQAINAVGALLTGVVLVIVLITKFTHGAWIVAIAMPLLFLAMRGVHEHYRRVAGELAVAPDARPWEPAGNHVVVLVSALHAPTLKALGYARALRPTSLYALTVAVDPRDVQGLREQWDAHDIDVALQVLSSPYRDFTRPVIDYVTDVGARNPGGALTVVIPEYIVGHWWEHLLHNQSALRLKARLLFTPGVTVVNVPYRLSSSRAPRSRRDGRVTG
>NZ_CP047146.1|WP_159507355.1|6553594_6554410_+|polysaccharide-deacetylase-family-protein
MTRRLLLRTAVVIGTLATARVLLSPDDDVPPAGPGPQTRGRPPAAAPGSAPPDTSRLRPLAGETSRSGPGASPPHADVARTVPARAGQIALTFDDGPDPRYTPEILEALRRHGTRATFFVVGEHAVEFPDLLHFIADEGHAIGNHTWTHPQLTALPPGRVRTELGRTSALIEEVVGTAPRLARAPYGDWDQTSLDICDDLGMSPVGWSVDSRDWTRPGPESIADTVVDELRPGAIVLSHDGGGNRIETVQALDWYLPQLLDGGFRPVRISP
>NZ_CP047146.1|WP_159507356.1|6554652_6557007_+|MMPL-family-transporter
MSLPNSPSGPGSRRPEGALRRIGEWCARHAVAVLVLWLVALAGVQVLQRTFGGEYSDDFSLPGVQSSQGRDVLARHDPEAGGYTGQVVLHDRTQPLAAVGGQIADAVTDLGRLPDVLAAQSPLPPPGSPPKPPAPGTPNTGPLSADGRTGYLAVRFRVPPVTLGPEYLAGVDRAVAPLRAAGVQVEYGGSLGELARPRTDDRLSEAIGFAVAVLVLLAGFGSVLAAGLPLLTALIGVVCGLGCLGLLAAAFTFATVSPTLATMIGLGVGIDYALLLITRHRQHLMDGAAPEVAAGRAVAGSGRAVLVSGVTVVIALTGLSVSGVGFVGKLGMAAAITVVTAVLGALTLVPALLGLLGRGIDRFPVRRPVAEAHPAPDGAAPGGRRRYAQRVARRPWWYLVGGVFVVAVLAVPLFSMRLGHIGDGADPVSFTDRRAFDLMSSAFGPGSTGPLTLVIDRSEVQQADRPALAEQAQQVLAGVPGAAAVTPLRPTPDGAALTATAYPAQGPQQPGTTTLVHRLVHTVLPEAVRGYDAYGYVTGTTAGQVDFLDSVAGRLPLIIAVVVALAFLILLIVFRGVLVAVKAAVLNILSIAASYGVVVAVFQWGWGGPALGVSGTVPIEGYVPMMMFAIVFGLSMDYEIFLLSRVHENWLRTADSRASVTHALETTARVITCAALIMVSLFAAFLLSDNIVVKMLGLGLAVSVLIDATVVRLLLVPALLALLGPRAWWTPWWLDRVLPYVDAEGQAPRAPRRARRAAAAPPCADRPGPRSSNYGPDRRTRLRR
>NZ_CP047146.1|WP_159507357.1|6556972_6558016_+|ATP-dependent-DNA-ligase
MAPTAGRGFADEPDHPHDPESAAASPYPVDPTYPGYPVIQPMLATLGPLPAEHEQPEWAFEAKWDGARCVVNTPGDGTVRLVTRAGNDATLTYPELGPLGEQLRGRPAVLDGEVVVLDAGGRPDFGLLQRRMGVVNPRRTARLAMELPVQLILFDLMYLGGWLVDFPYHERRAVLSGLRLGGPNWSVPAYVEGRGQQAWEAALRGGHEGVMAKRLTSRYVPGVRSPDWRKTKHLETLDIVIGGWTEGHGVLTGLPGSVVAGLPEPAGLRYVGSVGSGLSDRERRELAQYLGVIPLDRSPFRNPVDLPGVHWVEPRLVAEISITGWTSADRVRHPIWHRLRPDLTRLG

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Crispr_ID: NZ_CP047146_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_11

7730828-7730928

Orphan

Consensus_repeat	Method
CGGAAGACCGCCGCCGCCAAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP047146_11

>merge|NZ_CP047146|11|7730828-7730928|CRISPRCasFinder
CGGAAGACCGCCGCCGCCAAGGCTGCCGAGGCCGGCACCGCCGAGGAGGCCCCGGCGAAGCCCAAGCGGACCCGCACCCGGAAGACCGCCGCCGCCAAGGC

>NZ_CP047146|11|11|7730828-7730928|CRISPRCasFinder
CGGAAGACCGCCGCCGCCAAGGC	TGCCGAGGCCGGCACCGCCGAGGAGGCCCCGGCGAAGCCCAAGCGGACCCGCACC
CGGAAGACCGCCGCCGCCAAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159508180.1\|7734902_7735757_-\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223686
NZ_CP047146.1\|WP_159508182.1\|7736780_7737419_-\|suppressor-of-fused-domain-protein	unknown	unknown	gnl\|CDD\|377450
NZ_CP047146.1\|WP_159508178.1\|7732254_7732707_+\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176856
NZ_CP047146.1\|WP_159510377.1\|7739762_7740446_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508175.1\|7727715_7728453_-\|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein	unknown	unknown	gnl\|CDD\|205967
NZ_CP047146.1\|WP_159510375.1\|7722993_7724463_-\|DUF3152-domain-containing-protein	unknown	unknown	gnl\|CDD\|371483
NZ_CP047146.1\|WP_159508168.1\|7718538_7719498_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|366597
NZ_CP047146.1\|WP_159508171.1\|7725689_7725914_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508169.1\|7720943_7722710_-\|DUF3492-domain-containing-protein	unknown	unknown	gnl\|CDD\|340841
NZ_CP047146.1\|WP_159508172.1\|7726062_7726704_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP047146.1\|WP_159508167.1\|7716832_7718011_-\|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl\|CDD\|181156
NZ_CP047146.1\|WP_159508174.1\|7727365_7727656_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508170.1\|7724459_7725539_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP047146.1\|WP_159510376.1\|7734116_7734722_-\|NAAT-family-transporter	unknown	unknown	gnl\|CDD\|225006
NZ_CP047146.1\|WP_159508177.1\|7731148_7732042_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP047146.1\|WP_159508173.1\|7726821_7727049_+\|DUF3107-family-protein	unknown	unknown	gnl\|CDD\|378634
NZ_CP047146.1\|WP_159508184.1\|7739202_7739742_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99816
NZ_CP047146.1\|WP_159508183.1\|7737937_7739056_+\|magnesium-transporter-CorA	unknown	unknown	gnl\|CDD\|213364
NZ_CP047146.1\|WP_159508181.1\|7735927_7736566_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508179.1\|7732722_7733658_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350289

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159508180.1\|7734902_7735757_-\|PHP-domain-containing-protein	gnl\|CDD\|223686	COG0613, COG0613, Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only].	9.475e-46
NZ_CP047146.1\|WP_159508182.1\|7736780_7737419_-\|suppressor-of-fused-domain-protein	gnl\|CDD\|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	1.55416e-26
NZ_CP047146.1\|WP_159508172.1\|7726062_7726704_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.86893e-16
NZ_CP047146.1\|WP_159508175.1\|7727715_7728453_-\|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein	gnl\|CDD\|205967	pfam13794, MiaE_2, tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like.	5.0427e-89
NZ_CP047146.1\|WP_159510375.1\|7722993_7724463_-\|DUF3152-domain-containing-protein	gnl\|CDD\|371483	pfam11350, DUF3152, Protein of unknown function (DUF3152). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	4.64993e-61
NZ_CP047146.1\|WP_159508168.1\|7718538_7719498_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|366597	pfam01370, Epimerase, NAD dependent epimerase/dehydratase family. This family of proteins utilize NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions.	9.71713e-42
NZ_CP047146.1\|WP_159508169.1\|7720943_7722710_-\|DUF3492-domain-containing-protein	gnl\|CDD\|340841	cd03813, GT4-like, glycosyltransferase family 4 proteins. This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.	1.16495e-130
NZ_CP047146.1\|WP_159508178.1\|7732254_7732707_+\|SRPBCC-domain-containing-protein	gnl\|CDD\|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	1.32989e-35
NZ_CP047146.1\|WP_159508167.1\|7716832_7718011_-\|adenylyltransferase/sulfurtransferase-MoeZ	gnl\|CDD\|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NZ_CP047146.1\|WP_159508170.1\|7724459_7725539_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	3.93369e-27
NZ_CP047146.1\|WP_159510376.1\|7734116_7734722_-\|NAAT-family-transporter	gnl\|CDD\|225006	COG2095, MarC, Multiple antibiotic transporter [Intracellular trafficking and secretion].	1.14491e-39
NZ_CP047146.1\|WP_159508177.1\|7731148_7732042_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	5.01796e-18
NZ_CP047146.1\|WP_159508173.1\|7726821_7727049_+\|DUF3107-family-protein	gnl\|CDD\|378634	pfam11305, DUF3107, Protein of unknown function (DUF3107). Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	1.20898e-34
NZ_CP047146.1\|WP_159508183.1\|7737937_7739056_+\|magnesium-transporter-CorA	gnl\|CDD\|213364	cd12830, MtCorA-like, Mycobacterium tuberculosis CorA-like subfamily. This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	6.35655e-170
NZ_CP047146.1\|WP_159508184.1\|7739202_7739742_+\|hypothetical-protein	gnl\|CDD\|99816	cd06220, DHOD_e_trans_like2, FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as 3 cofactors: FMN, FAD, and an [2Fe-2S] cluster.	0.00330295
NZ_CP047146.1\|WP_159508179.1\|7732722_7733658_-\|NYN-domain-containing-protein	gnl\|CDD\|350289	cd18722, PIN_NicB-like, LabA-like PIN domain of Pseudomonas putida S16 NicB and related proteins. Curiously NicB from Pseudomonas putida S16 is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine. This subfamily also includes the uncharacterized CPP15 (plasmid) protein from Campylobacter jejuni. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.81912e-08

>NZ_CP047146.1|WP_159508175.1|7727715_7728453_-|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein
METPDNAAADAQEHTGIAAQDWEQASTEPQYRAAVIDLLGALAYGELSAFERLAEDAKLAPTMDDKAELAKMASAEFHHFERLRDRLAEIEAEPNEAMEPFAAALDEFHRQTAPSDWLEGLVKAYVGDSIASDFYREVAARLDSDTRDLVLAVLDDTGHATFAVEKVRAAIEAEPRVGGRLALWARRLMGEALSQAQRVVADRDALSTMLVGGVADGFDLAEVGRMFSRITEAHTKRMAALGLAA
>NZ_CP047146.1|WP_159508174.1|7727365_7727656_+|hypothetical-protein
MIWEALGAVIVGFAIALSARRWLPERFPAHALTLATGPVAALLGALLTHSILGPGHPVQAMLAAVAVGAALLSVLARPPRRRVRRPAPALKGHRTA
>NZ_CP047146.1|WP_159508173.1|7726821_7727049_+|DUF3107-family-protein
MEVKIGVQHAPREIVLDCGQSAEEVERAVSDALSGKSELLSLVDDHGRKVLVAAARLAYVEIGEPTTRKVGFGAP
>NZ_CP047146.1|WP_159508172.1|7726062_7726704_+|TetR-family-transcriptional-regulator
MSAIEQTEAARPRGTRLPRRARRNQLLGAAQEVFVAQGYHAAAMDDIAERAGVSKPVLYQHFPGKLELYLALLDQHCEALLHSVRKALESTTDNKQRVAATMDAYFAYVEDPGGAFRLVFESDLTNEPAVRERVDKVSLECAEAISAVIAEDTGLSQDESMLLAVGLGGVSQVVARYWLSSESEVPRETAVQLLTSLAWKGIAGFPLHGSDTH
>NZ_CP047146.1|WP_159508171.1|7725689_7725914_+|hypothetical-protein
MRVDPTDPDTFEDDSGTATLTEFDVEASEADAAEQHTDVAPHRDEPLGGMEDSANEADRAEQARVVELNEDEYR
>NZ_CP047146.1|WP_159508170.1|7724459_7725539_-|alpha/beta-fold-hydrolase
MSSTESPDTATAAALPVPPAGPGARGAAGETVRWVTLPGLTLNVRTPAGPPEADAADRAKAAVRDREPALYVHGLGGSSLNWSALMPLLADRVAGEAVDLPGFGDSPPPDDGNYSIPAQARTVVRYLDAAGRGPVHLIGNSLGGAVVTRVAAARPDLVRTLTLISPALPEIPPQLTALPTAMLGIPGIAGLFRRLTREWTPEQRTRGVLTLCYGDPARITPEGFNAAVDEYVRRLELPYFWEVMERTARGLVNAYTLGGQHGLWRQAERVLAPTLLVYGGRDRLVSHRMARRAAAAFRGSRLVTLPEAGHVAMMEYPETVARSFRELLDSGTTVTDATSGAGTGSAGAAPAGPPVADRS
>NZ_CP047146.1|WP_159510375.1|7722993_7724463_-|DUF3152-domain-containing-protein
MTGPVGRHSRRDRQNRAADRSDVPPGAVGPPPTAGPGRRRQGTAGPPAGGDEVRGGHPEQREPGGGWGAFPGSAGPGTRTAGAPRIPGPRAAEPETSMFGTPLAAPGSGPGPRPEYLAAFAGGGSPRFPDGADGGDGADGADDDVFRAGAPGVRPYGPDGGGAGDGLPPGGRFTGRSVVFDRERIAELDRREERAAEGAETGGPDGPDDPDAAAGSRSGGAGKGAKGRTFTGAAAAAVTTVLAVVIAGQVADQHPQGDDGRSHSGDDRADGGTEASRSQTRTGQDAKPAGYAAQMARVFPLDPQLTASGHFTPVGGDARAPGRGKVLRYRVDVEDGLPLDGALFAEAVHKTLNDDRSWAHGGQRTFQRVASGDADFVISLASPGTTAKWCAKSGLDTTEDNVSCDSAATDRVMINAYRWAQGAKTYGPDKMLAYRQMLINHEVGHRLGHNHEVCPRQGALAPVMMQQTKFLTTDGVTCRPNSWPYPTGR
>NZ_CP047146.1|WP_159508169.1|7720943_7722710_-|DUF3492-domain-containing-protein
MRIGLLTEGGYPYASGESHEWCDRLVRGLTGHDFEIYALTADARQETGGRRGHRELPDHVRLVGQAPLSGDFPAECRRPAEDRRGRAAGRRTRRRFAGHFADLVAAFATPPAVESAAVGGEADRFASGLYGLAELARAGAALPALLRSEEAVRILEGICRGPGALPAARGGQLTDLLAVADALESALRPLSLDWYGETGLARVDLCHATSGGAAALPGLLAKRFFGTPLLVTEYGVRLREHYLAPAAEPLSAPVRALLAAFRRALAAETYAQAALITPGNTHARRWQEHCGADPARLRTVYPGMDAGRFAEVADAAADDSRALVWVGDIEPAKDLIGLLHAFAEVRRAEPAATLRIIGGLGDDPEAAGYRAQCRALAAQLFPDEAADARTAGESPVGFEEIGSPDAPTLEAAYASGAVLVLSSAVEGFPRSLIEGMFCGRATVSTDTGAVCEVIGGTGLVVPPRNPRALADACRALLADPDRRARLGAAARARALELFTVEQNVAAFRGIYLDLISHAPAGPAAYRARARDGVPRPFERPAESHVPGRWAAAGPAPRRPSWALADGECRRARRKRYGAAGEPAVRQAW
>NZ_CP047146.1|WP_159508168.1|7718538_7719498_-|NAD-dependent-epimerase/dehydratase-family-protein
MRVLLIGANGYLGRYVADRLLADPAVQLTALGRGDDADVRFDLATGSPGALTRFLDAVHPGVVVNCAGATRGGARELTRHNTVAVATICESLRRSGCGARLVHLGCASEYGPSQPGSSTAEDAVPRPGGPYGVSKLAATELVLGSGLDAVVLRVFSPVGPGTPAGSPLGRLAEAMRRAMQSGDNELKLGGLGVQRDFVDVRDVARAVHAASLSAAQGVVNIGTGRAVRLREAAAVLARVAGFGGSLHELDSPPARLVIPGPGPEGHPMGSPPATYPYPDGCGTWQQADVRTARDRLGWRPRIGLEESLADIWMEAACRI
>NZ_CP047146.1|WP_159508167.1|7716832_7718011_-|adenylyltransferase/sulfurtransferase-MoeZ
MSLPPLVEPAPELTVDEVRRYSRHLIIPDVGMDGQKRLKNAKVLCVGAGGLGSPALMYLAAAGVGTLGIVEFDEVDESNLQRQIIHSQADIGRSKAASAKDTVLGINPYVTVNLHEERLDSTNVMELFAQYDLIVDGTDNFATRYLVNDACVLLNKPYVWGSIYRFDGQASVFWSEHGPCYRCLYPEPPPPGMVPSCAEGGVLGVLCASIGSIQVNEAIKLLAGIGEPLVGRLMIYDALEMTYRQVKVRKDPNCAVCGENPTVTELIDYEAFCGVVSEEAQEAAAGSTITPKQLKEWIDADEKIEIIDVREPNEFEIVSIPGAKLIPKNEFLMGSALQDLPQDRKIVLHCKTGVRSAEVLAVLKSAGFADAVHVGGGVIGWVNTVEPEKPVY
>NZ_CP047146.1|WP_159508177.1|7731148_7732042_+|alpha/beta-fold-hydrolase
MSRPPTLALPACARAYRLDTARGAFAVHDARPDGAPIGTALLVPGFTGSKEDFIALLAPLAASGFRAVAVDGRGQHESPGPRDEPAYAQEELALDVLAQAAAVRNPGGGPLHLLGHSLGGLITRAAVLRDPAPFRSLTVLSSGPAAIDANQQTRVRMLIEALGTIDMERVWEAMRALDAPPADADGTPVPAADEATPTEIGAFLRQRWLNTVPEQLIATGRQMLAEPDRVAELARTGLPTHVVSGAVDYAWPVGLMDEMARRLAARRTVIEGAEHSPNAERPAKTAEALAGFWSEVG
>NZ_CP047146.1|WP_159508178.1|7732254_7732707_+|SRPBCC-domain-containing-protein
MTQQPSQGFALSRTFEAPLERVFAAWTTPEHFAHWFGGELAVPVERMTMDVRPGGVWSLVMHTPDGGELPFSGVYQEVAAPERLVFTLKDAFAPEDAAGETVRVALAARGGRTEMAFRQDGGNLTAEQYQQAEAGWSGFFDRLAELLARP
>NZ_CP047146.1|WP_159508179.1|7732722_7733658_-|NYN-domain-containing-protein
MNDVPPTGSTDRTALDALAAGVERTNELLTRVLAEVATTPSTHAVFVDAGYVYAATGRLVAGTEDRKAFELDAEGLIEAFIDKARTIFPDSRLLRVYWYDGARRRIHTQEQQRIAELPDVKVRLGNLNANNQQKGVDSLIRTDLESLARHRAISDAVLIGGDEDLVSAVEAAQGYGARVHLWGIEAPGGRNQAEPLMWEVDSARIFDLDFCKPYVTRRTAGECPEAGAGEGPVPSREEVRFVGARVAAQWLAERGRAWVAELLPGHPYLPGTVDQELLTAAEAILRHSLRGHADLRRVLRDGFWDHVQGQY
>NZ_CP047146.1|WP_159510376.1|7734116_7734722_-|NAAT-family-transporter
MFDVAVFSTLFVTLFVIMDPPGITPIFLALTSGRPAKVQRRMAWQAAAVAFGVIAVFGLFGQQILGRLHISTPALMIAGGLLLLLVALDLLTGKSEEPTQTKDVNVALVPLGMPLLAGPGAIVSVILAVQHAHGVAAQISVWAAIAAIHVVLYLVMRFSLVIIRVIKDGGVVLVTRLAGMMLSALAVQQIINGVTQVIQGT
>NZ_CP047146.1|WP_159508180.1|7734902_7735757_-|PHP-domain-containing-protein
MRIDLHTHSTASDGTDTPAELVRNAARAGLDVVALTDHDTVGGHAEARAALPEGLTLVTGAELSCRLDGVSLHLLAYLFDPEEPELARERELVRDDRVPRARAMVGKLRDLGVPVTWEHVARIAGDGAVGRPHIATALVELGVVGSVSDAFTSQWLANDGRAYVEKHELDPFDAIRLVRAAGGVTVFAHPLAVKRGSCVPESAIADLAAAGLDGIEVDHMDHDAPTRARLRGLAAELGLLTTGSSDYHGSRKTCRLGDCTTDPEIYGEIVRRATGAFPVPGTGG
>NZ_CP047146.1|WP_159508181.1|7735927_7736566_-|hypothetical-protein
MRGEPSCPKCGGRVRAPGLFSDTWQCAAHGTVHPLQPVVPPSVEALGVVVHRAQVPVWMPWPLPVGWLFTGVACAGDDRSGGRATAVACSGPGPLGGPGELLLVAEELGVGLGARYAGIDGPDPGAHMCVEKSPHAKVLAAGRPTPLWHVDGAPTDRAVFAGEARGLWLWAIAWPERSGVLLYDELVLTDLREAGAEVDLLPCGALSPRILS
>NZ_CP047146.1|WP_159508182.1|7736780_7737419_-|suppressor-of-fused-domain-protein
MSDVLELVEARLRTALGEPDARAAITFLGTDRIEVLRFVDSDVVRYATLGMSAQPMADPAGPSPDHHPSASRFAAPLSVVVADPVRGPRAELLLSVRAGRADTDKVLHPLAVLAASPQVEGVVVAPGASLDVGDPLWPGAPFTSVLVSAPGGLVEDLELDEPMDPVRFLPLLPMTPNEAAWKRVHGAEALEERWLRQGTDLRDPLRRSVPLD
>NZ_CP047146.1|WP_159508183.1|7737937_7739056_+|magnesium-transporter-CorA
MSMIRDLRAAVRPSRRRADSESAAPACANSAIVDCGVYREGHRVREHLSPAEAMASVRADGGFTWIGLHEPTEAEFAGIAQEFGLHPLAVEDAVHAHQRPKLERYDDTLFTVFKTVHYVEHTELTATSEVVETGEVMCFIGRDFIVTVRHGGQGSLRALRHRLQDDPELLAKGPSAVLHAIADQVVDGYIAVAGAVQDDIDEVEIDVFSSATTGRGAGGKGSATRGGDAGRIYQLKREVLEFKRAVSPLLRPMQLLSERPMRLVDADIQKYFRDVADHLARVNEQVLSFDDLLNSILQANLAQAAVAQNEDMRKITAWAAIFAVPTMIAGIYGMNFQYMPELHWKYGYPAMMLVTVAICTGIHRGFKRNGWL
>NZ_CP047146.1|WP_159508184.1|7739202_7739742_+|hypothetical-protein
MTETVSQALQDRALIEEATKKSGLIWVRGTTGPARALWHVWHDGAACLVGGGSGEQPLDGLGLADGGTATVTVRSKDKGGRLVAWQARVHEPAPRSEAWLAAVEELRGKRLNAPDADTLTERWARECRVLRLEPAGGAVQRPGLMPDDAQAAPPLASPATTRRPLPAALPKLLRRGRRG
>NZ_CP047146.1|WP_159510377.1|7739762_7740446_-|hypothetical-protein
MAAVLAGCGAEDPDAGTNGVGKLPAATIESKAQAAAKGADSVHLSGNVVSQGGTYKLDMRLAKNGARGELSTKAAGFQLLRVGDALYLKADAAFWAGEKSGSGPASATAAKLGGKYVKVPATDPVYQRFSGFTDKDTLLAGLLGLHGALAVGEHGSLDGVRTVRLTAGSGSGGTLDVSLEGTPYPLRLRRAGGAGEVRLDDWGKSVDLKTPDAGQTVDLGKQISGTG

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Crispr_ID: NZ_CP047146_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_12

7739035-7739144

Orphan

Consensus_repeat	Method
CAAGAGGAACGGGTGGCTGTGAGGCGGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP047146_12

>merge|NZ_CP047146|12|7739035-7739144|CRISPRCasFinder
CAAGAGGAACGGGTGGCTGTGAGGCGGCGGGCGGTCGCACCGGCGGCCGGGGGTCCGGGGGTTGCCCCCGGGGGACGCCGCAAGAGGAACGGGTGGCTGTGAGGCGGCGG

>NZ_CP047146|12|12|7739035-7739144|CRISPRCasFinder
CAAGAGGAACGGGTGGCTGTGAGGCGGCGG	GCGGTCGCACCGGCGGCCGGGGGTCCGGGGGTTGCCCCCGGGGGACGCCG
CAAGAGGAACGGGTGGCTGTGAGGCGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159508180.1\|7734902_7735757_-\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223686
NZ_CP047146.1\|WP_159508182.1\|7736780_7737419_-\|suppressor-of-fused-domain-protein	unknown	unknown	gnl\|CDD\|377450
NZ_CP047146.1\|WP_159508189.1\|7744752_7745256_-\|Sec-independent-protein-translocase-TatB	unknown	unknown	gnl\|CDD\|179287
NZ_CP047146.1\|WP_159510377.1\|7739762_7740446_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508175.1\|7727715_7728453_-\|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein	unknown	unknown	gnl\|CDD\|205967
NZ_CP047146.1\|WP_159508187.1\|7742714_7743878_+\|P-loop-NTPase	unknown	unknown	gnl\|CDD\|378455
NZ_CP047146.1\|WP_159508181.1\|7735927_7736566_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508178.1\|7732254_7732707_+\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176856
NZ_CP047146.1\|WP_159508186.1\|7742077_7742671_+\|DUF1003-domain-containing-protein	unknown	unknown	gnl\|CDD\|377629
NZ_CP047146.1\|WP_159508176.1\|7728763_7731043_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP047146.1\|WP_159508174.1\|7727365_7727656_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159510376.1\|7734116_7734722_-\|NAAT-family-transporter	unknown	unknown	gnl\|CDD\|225006
NZ_CP047146.1\|WP_159508177.1\|7731148_7732042_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP047146.1\|WP_159508188.1\|7743987_7744635_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159510378.1\|7748549_7749350_-\|RNA-polymerase-sigma-factor-SigE	unknown	unknown	gnl\|CDD\|236606
NZ_CP047146.1\|WP_159508190.1\|7745372_7747466_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP047146.1\|WP_159508185.1\|7740780_7742088_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|225148
NZ_CP047146.1\|WP_159508191.1\|7747614_7748553_-\|zf-HC2-domain-containing-protein	unknown	unknown	gnl\|CDD\|274904
NZ_CP047146.1\|WP_159508184.1\|7739202_7739742_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99816
NZ_CP047146.1\|WP_159508179.1\|7732722_7733658_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350289

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159508180.1\|7734902_7735757_-\|PHP-domain-containing-protein	gnl\|CDD\|223686	COG0613, COG0613, Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only].	9.475e-46
NZ_CP047146.1\|WP_159508182.1\|7736780_7737419_-\|suppressor-of-fused-domain-protein	gnl\|CDD\|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	1.55416e-26
NZ_CP047146.1\|WP_159508189.1\|7744752_7745256_-\|Sec-independent-protein-translocase-TatB	gnl\|CDD\|179287	PRK01371, PRK01371, Sec-independent protein translocase protein TatB.	2.65828e-46
NZ_CP047146.1\|WP_159508175.1\|7727715_7728453_-\|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein	gnl\|CDD\|205967	pfam13794, MiaE_2, tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like.	5.0427e-89
NZ_CP047146.1\|WP_159508187.1\|7742714_7743878_+\|P-loop-NTPase	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	1.54743e-131
NZ_CP047146.1\|WP_159508178.1\|7732254_7732707_+\|SRPBCC-domain-containing-protein	gnl\|CDD\|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	1.32989e-35
NZ_CP047146.1\|WP_159508186.1\|7742077_7742671_+\|DUF1003-domain-containing-protein	gnl\|CDD\|377629	pfam06210, DUF1003, Protein of unknown function (DUF1003). This family consists of several hypothetical bacterial proteins of unknown function.	2.41343e-46
NZ_CP047146.1\|WP_159508176.1\|7728763_7731043_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	3.9238e-144
NZ_CP047146.1\|WP_159510376.1\|7734116_7734722_-\|NAAT-family-transporter	gnl\|CDD\|225006	COG2095, MarC, Multiple antibiotic transporter [Intracellular trafficking and secretion].	1.14491e-39
NZ_CP047146.1\|WP_159508177.1\|7731148_7732042_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	5.01796e-18
NZ_CP047146.1\|WP_159510378.1\|7748549_7749350_-\|RNA-polymerase-sigma-factor-SigE	gnl\|CDD\|236606	PRK09647, PRK09647, RNA polymerase sigma factor SigE; Reviewed.	2.01637e-117
NZ_CP047146.1\|WP_159508190.1\|7745372_7747466_-\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.05397e-84
NZ_CP047146.1\|WP_159508185.1\|7740780_7742088_+\|CBS-domain-containing-protein	gnl\|CDD\|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	3.53502e-49
NZ_CP047146.1\|WP_159508191.1\|7747614_7748553_-\|zf-HC2-domain-containing-protein	gnl\|CDD\|274904	TIGR03988, antisig_RsrA, mycothiol system anti-sigma-R factor. Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors].	1.47457e-07
NZ_CP047146.1\|WP_159508184.1\|7739202_7739742_+\|hypothetical-protein	gnl\|CDD\|99816	cd06220, DHOD_e_trans_like2, FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as 3 cofactors: FMN, FAD, and an [2Fe-2S] cluster.	0.00330295
NZ_CP047146.1\|WP_159508179.1\|7732722_7733658_-\|NYN-domain-containing-protein	gnl\|CDD\|350289	cd18722, PIN_NicB-like, LabA-like PIN domain of Pseudomonas putida S16 NicB and related proteins. Curiously NicB from Pseudomonas putida S16 is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine. This subfamily also includes the uncharacterized CPP15 (plasmid) protein from Campylobacter jejuni. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.81912e-08

>NZ_CP047146.1|WP_159508182.1|7736780_7737419_-|suppressor-of-fused-domain-protein
MSDVLELVEARLRTALGEPDARAAITFLGTDRIEVLRFVDSDVVRYATLGMSAQPMADPAGPSPDHHPSASRFAAPLSVVVADPVRGPRAELLLSVRAGRADTDKVLHPLAVLAASPQVEGVVVAPGASLDVGDPLWPGAPFTSVLVSAPGGLVEDLELDEPMDPVRFLPLLPMTPNEAAWKRVHGAEALEERWLRQGTDLRDPLRRSVPLD
>NZ_CP047146.1|WP_159508181.1|7735927_7736566_-|hypothetical-protein
MRGEPSCPKCGGRVRAPGLFSDTWQCAAHGTVHPLQPVVPPSVEALGVVVHRAQVPVWMPWPLPVGWLFTGVACAGDDRSGGRATAVACSGPGPLGGPGELLLVAEELGVGLGARYAGIDGPDPGAHMCVEKSPHAKVLAAGRPTPLWHVDGAPTDRAVFAGEARGLWLWAIAWPERSGVLLYDELVLTDLREAGAEVDLLPCGALSPRILS
>NZ_CP047146.1|WP_159508180.1|7734902_7735757_-|PHP-domain-containing-protein
MRIDLHTHSTASDGTDTPAELVRNAARAGLDVVALTDHDTVGGHAEARAALPEGLTLVTGAELSCRLDGVSLHLLAYLFDPEEPELARERELVRDDRVPRARAMVGKLRDLGVPVTWEHVARIAGDGAVGRPHIATALVELGVVGSVSDAFTSQWLANDGRAYVEKHELDPFDAIRLVRAAGGVTVFAHPLAVKRGSCVPESAIADLAAAGLDGIEVDHMDHDAPTRARLRGLAAELGLLTTGSSDYHGSRKTCRLGDCTTDPEIYGEIVRRATGAFPVPGTGG
>NZ_CP047146.1|WP_159510376.1|7734116_7734722_-|NAAT-family-transporter
MFDVAVFSTLFVTLFVIMDPPGITPIFLALTSGRPAKVQRRMAWQAAAVAFGVIAVFGLFGQQILGRLHISTPALMIAGGLLLLLVALDLLTGKSEEPTQTKDVNVALVPLGMPLLAGPGAIVSVILAVQHAHGVAAQISVWAAIAAIHVVLYLVMRFSLVIIRVIKDGGVVLVTRLAGMMLSALAVQQIINGVTQVIQGT
>NZ_CP047146.1|WP_159508179.1|7732722_7733658_-|NYN-domain-containing-protein
MNDVPPTGSTDRTALDALAAGVERTNELLTRVLAEVATTPSTHAVFVDAGYVYAATGRLVAGTEDRKAFELDAEGLIEAFIDKARTIFPDSRLLRVYWYDGARRRIHTQEQQRIAELPDVKVRLGNLNANNQQKGVDSLIRTDLESLARHRAISDAVLIGGDEDLVSAVEAAQGYGARVHLWGIEAPGGRNQAEPLMWEVDSARIFDLDFCKPYVTRRTAGECPEAGAGEGPVPSREEVRFVGARVAAQWLAERGRAWVAELLPGHPYLPGTVDQELLTAAEAILRHSLRGHADLRRVLRDGFWDHVQGQY
>NZ_CP047146.1|WP_159508178.1|7732254_7732707_+|SRPBCC-domain-containing-protein
MTQQPSQGFALSRTFEAPLERVFAAWTTPEHFAHWFGGELAVPVERMTMDVRPGGVWSLVMHTPDGGELPFSGVYQEVAAPERLVFTLKDAFAPEDAAGETVRVALAARGGRTEMAFRQDGGNLTAEQYQQAEAGWSGFFDRLAELLARP
>NZ_CP047146.1|WP_159508177.1|7731148_7732042_+|alpha/beta-fold-hydrolase
MSRPPTLALPACARAYRLDTARGAFAVHDARPDGAPIGTALLVPGFTGSKEDFIALLAPLAASGFRAVAVDGRGQHESPGPRDEPAYAQEELALDVLAQAAAVRNPGGGPLHLLGHSLGGLITRAAVLRDPAPFRSLTVLSSGPAAIDANQQTRVRMLIEALGTIDMERVWEAMRALDAPPADADGTPVPAADEATPTEIGAFLRQRWLNTVPEQLIATGRQMLAEPDRVAELARTGLPTHVVSGAVDYAWPVGLMDEMARRLAARRTVIEGAEHSPNAERPAKTAEALAGFWSEVG
>NZ_CP047146.1|WP_159508176.1|7728763_7731043_+|DEAD/DEAH-box-helicase
MAVVPRPSGPSGRHRTNPYEGAVRPPSPPPTASHRRGKILSTFRELGIFPETAEALEAVGIVSPFPIQELTLPVALSGNDVIGQAKTGTGKTLGFGLPLLERVTVPADVEAGRAKPEQLTEAPQALVVVPTRELCQQVTNDLLTAGKVRNVRVLAIYGGRAYEPQVEALKKGVDVVVGTPGRLLDLAGQKKLSLSQVRTLVLDEADEMLDLGFLPDVEKIIQLLPAKRQTMLFSATMPGQVISLARRYMSQPTHIRATAPDDEGATVANITQHVYRAHSMDKPEMVARILQADGRGLAMLFCRTKRTAADIADQLARRGFASGAVHGDLGQGAREQALRAFRNGKVDVLVCTDVAARGIDVEGVTHVVNYQSPEDEKTYLHRIGRTGRAGAKGTAITLVDWDDIPRWKLINKALDLPFDEPEETYSTSPHLYEQLGIPEGTKGILPRAERTRAGLAAEEVEDLGETGGRGRGRRGGAPAAEEERPRRTRTPRQRRRTRGGSLVDDTAAPEAQASEAVDAAEGAEAAAAGPRTPRRRRRTRGSVAASAAAEARETAAATVAEAPAVTAVVEPAAPAAEETPAAAPRRRRTRSAAKAAVDAVSEAATAPVETVQEAAADAVEAKPKRTRTRKTAAAKAETAPAADAADAVEAKPKRTRTRKTAAAKAEAAVDTAEGTAVEAEAPAKPKRTRKTAAAKAAEAGTAEEAPAKPKRTRTRKTAAAKAEAAPAADVPDAAEAKPKRTRKRAAAKPAEAAETASAS
>NZ_CP047146.1|WP_159508175.1|7727715_7728453_-|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein
METPDNAAADAQEHTGIAAQDWEQASTEPQYRAAVIDLLGALAYGELSAFERLAEDAKLAPTMDDKAELAKMASAEFHHFERLRDRLAEIEAEPNEAMEPFAAALDEFHRQTAPSDWLEGLVKAYVGDSIASDFYREVAARLDSDTRDLVLAVLDDTGHATFAVEKVRAAIEAEPRVGGRLALWARRLMGEALSQAQRVVADRDALSTMLVGGVADGFDLAEVGRMFSRITEAHTKRMAALGLAA
>NZ_CP047146.1|WP_159508174.1|7727365_7727656_+|hypothetical-protein
MIWEALGAVIVGFAIALSARRWLPERFPAHALTLATGPVAALLGALLTHSILGPGHPVQAMLAAVAVGAALLSVLARPPRRRVRRPAPALKGHRTA
>NZ_CP047146.1|WP_159508184.1|7739202_7739742_+|hypothetical-protein
MTETVSQALQDRALIEEATKKSGLIWVRGTTGPARALWHVWHDGAACLVGGGSGEQPLDGLGLADGGTATVTVRSKDKGGRLVAWQARVHEPAPRSEAWLAAVEELRGKRLNAPDADTLTERWARECRVLRLEPAGGAVQRPGLMPDDAQAAPPLASPATTRRPLPAALPKLLRRGRRG
>NZ_CP047146.1|WP_159510377.1|7739762_7740446_-|hypothetical-protein
MAAVLAGCGAEDPDAGTNGVGKLPAATIESKAQAAAKGADSVHLSGNVVSQGGTYKLDMRLAKNGARGELSTKAAGFQLLRVGDALYLKADAAFWAGEKSGSGPASATAAKLGGKYVKVPATDPVYQRFSGFTDKDTLLAGLLGLHGALAVGEHGSLDGVRTVRLTAGSGSGGTLDVSLEGTPYPLRLRRAGGAGEVRLDDWGKSVDLKTPDAGQTVDLGKQISGTG
>NZ_CP047146.1|WP_159508185.1|7740780_7742088_+|CBS-domain-containing-protein
MAVVTPRVFVSHLSGIAVFDPNGDQVGRLRDLVALLRVGARPPRLLGLVVEVISRRRIFLPMTRVTGVESGQVITTGVVNMRRFEQRASETLVFGELLDRRVRLVDTGEDVTVLDIGITQLPARRDWEIDKVFVRRGKGGPLRRKGETLTVEWSAVTGFSREEHGQGAENLLATFEQLRPADLAGVLHHLSPKRRAEVAAALDDDRLADVLEELPEDDQVEIIGKLKDERAADVLEAMDPDDAADLLSELPEEEKERLLTLMRPEEAADVRRLMAYEERTAGGLMTTEPIVLRPDATVADALARVRDPDLSPALAAQVYVCRPPDETPTGKYLGLVHFQRLLRDPPFTLVSSIVDTDLPALPPDTPLPEVTSYLAAYNMVAAPVVDESGALLGAVTVDDVLDHLLPEDWREAELHRAPPAGLTGVRAHGEAGDGR
>NZ_CP047146.1|WP_159508186.1|7742077_7742671_+|DUF1003-domain-containing-protein
MGAEEREGSRERRANGASALRRGGAGERPPERRRVRLDLPRVPRRTLFPEYDPEAFGRMSEKIARFLGTGRFIVWMTVAIILWIGWNVAVPGHLRFDNYPFIFLTLALSLQASYAAPLILLAQNRQDNRDRVTHEQDRKQNERSIADTEYLTREIAALRLGLGEVATRDWIRSELEDLLRELELRQMIDAESDERDR
>NZ_CP047146.1|WP_159508187.1|7742714_7743878_+|P-loop-NTPase
MANDTAPTAGAPSEDAIRDALATVNDPEIHRPITELGMVKSVDIAADGAVAVVVYLTVSGCPMRETIISSVREAVERVPGVTSAGVELEVMSDEQRRELAASLRGGTAEREVPFAQPGSLTRVYAVASGKGGVGKSSVTVNLAAAMAADGLKVGVVDADIYGHSVPRMLGADGRPTQVENMIMPPSANGVKVISIGMFTPGNAPVVWRGPMLHRALQQFLADVYWGDLDVLLLDLPPGTGDIAISVAQLVPNAEILVVTTPQQAAAEVAERAGSIAVQTHQKIVGVVENMSGLPCPHCDEMVDVFGTGGGERVAEGLTKTTGAQVPVLGSIPIDVRLREGGDEGKPVVLTDPDSPAGSAIRAIAGKLGGRQRGLAGMSLGITPRNKF
>NZ_CP047146.1|WP_159508188.1|7743987_7744635_-|hypothetical-protein
METTSRTVTQEVSADAGRKADGYLLAAFPWYGLDEAYTGPRWLMQVGSAADGTVEHGATGHGGEPTIKVETPESERFAVVVTVASRPVRRSADGTGVLEATSVSTAAWLAGAGLLAHTWPTQMDRSLRQDWLDQQTMIAWELADDLEGESWSELMLPVDGEPTPFCYRESEYGWVLAGTSGVDGGEGVHLGAYGRGMSAYGLGFSVIKDLSAYAG
>NZ_CP047146.1|WP_159508189.1|7744752_7745256_-|Sec-independent-protein-translocase-TatB
MFFDIGPLELIAIVVLAVLIFGPDKLPKVIQDVTGFIRKVRAFSDSAKEDIRSELGPEFKDFEFEDLKPRNFVRKHVLEKDEYGLKELQELRSGLDLKKEMAEVTDAVRESTSVSAAASTASSAPSNGSRPHLSEESPAGAAGRPDLLKKGADPAHRESPPFDADAT
>NZ_CP047146.1|WP_159508190.1|7745372_7747466_-|PDZ-domain-containing-protein
MDDAGAAGPKLKWWSRPGHTPSPQPPAEADRPEAQRSAGPAAGAAAAAAAAAPAGTAAAAEQASEAPELTAAPGAIPGPAADPAPAAAGPEQGAAAPRAEREAATVTLGQVPVGAPDEAQPHPPTEPAPRGAADPQPQPTVPAEAAGGAPRRPQPLHPEDPYGTPPYGGPGPWAPAPLVQRPMATPAHGTALPPEAGTAAADAPHPRPAAPGPQLLKAGGPVPAPAAPQDAVPHPGGPHPPAPAAPAAPASAPSGPQLTHEPAEGAFVPHPGDGGPRPVPVPPAAPYAAAPPPLRPSAVPGAWQQYDPWSAPLHGGPAAVPPRARRGRRVPMAVGAVVLALLAGGAGGGVGAYIERNGGIDDIKLPQATGERGSRSPQSVAGIARAALPGVVTLHVRGNAEQGTGTGFVLDRQGHILTNNHVVEAAGSGGAISVTFSGGQTAKARVVGRDGGYDLAVVQVDGVTGLRPLTLGDSDAAQVGDPVVAIGAPYDLANTVTSGIISAKQRPITAGGQKGDGSDVSYVDALQTDAPINPGNSGGPLVDGEARVIGINSAIRAADSGTGGPDGAGGQGGSIGLGFAIPINQAKRVAEELINTGRATHPVIGVTLEMEYAGDGARVSDRTKDGKPPVVPGGPGAKAGIKVGDVITQVDGVPVHSGQELIVKIRSHRPGDMLTLTLQRGGSERSVRLTLGSSSQG
>NZ_CP047146.1|WP_159508191.1|7747614_7748553_-|zf-HC2-domain-containing-protein
MSGSGGPSPAEQHLGDRLAALVDGELGHDARERVLAHLATCGKCKAEADAQRRLKNVFAQTAPPGPSEGLLARLQQLPGGDAGGPGSRLGTGTFGRSEFARGGGSFRYVPSENHLGPAMAAVPPQPRTRGFRVQEPERGAPQRRRFAFAAAGAVSLAAFALGGALPLEAAVDAPGPRAEGSGSAVTPLSASPAAGAVPLSRDEFLTTRDPRPGAWPAVGDPTIAPAPSAMALYAPGENRPSDGVPVAGPAPGRFGLAPLIAATGPASAYGFAPLTVTTGTAFAGRNPLPPLEPMRPLLGSAPSAGPLARGSH
>NZ_CP047146.1|WP_159510378.1|7748549_7749350_-|RNA-polymerase-sigma-factor-SigE
MVGALLDTTRATRGGAAAAGDRRVHRRLRRSFAEPKSVTNTADRFRPHGPKAMGGAPIADARTATFADTSDAQAWTPPTWEEIVSTHSARVYRLAYRLTGNQHDAEDLTQEVFVRVFRSLSTYTPGTFEGWLHRITTNLFLDMVRRRQRIRFDALGDDAAERLPSREPSPQQHFNDTHFDADVQQALDTLAPEFRAAVVLCDIEGLSYEEIAATLGVKLGTVRSRIHRGRSHLRKALKHRSPAARAEEREEQRSLAVVPTREVGIA

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Crispr_ID: NZ_CP047146_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP047146_13

8276744-8276836

Orphan

Consensus_repeat	Method
GCGTCCTCGCCGCCCTCTCCCTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP047146_13

>merge|NZ_CP047146|13|8276744-8276836|CRISPRCasFinder
GCGTCCTCGCCGCCCTCTCCCTCGCCACCGCCGCCGCCCGCGTCCTCATCCGGCGCCCCCGCGGTGCCCGCGTCGTCGCCGCCCTCTCCCTCG

>NZ_CP047146|13|13|8276744-8276836|CRISPRCasFinder
GCGTCCTCGCCGCCCTCTCCCTCG	CCACCGCCGCCGCCCGCGTCCTCATCCGGCGCCCCCGCGGTGCCC
GCGTCGTCGCCGCCCTCTCCCTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP047146.1\|WP_159508556.1\|8263412_8263982_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508569.1\|8280297_8280567_-\|DUF4031-domain-containing-protein	unknown	unknown	gnl\|CDD\|379076
NZ_CP047146.1\|WP_159508567.1\|8278186_8278837_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226789
NZ_CP047146.1\|WP_159508564.1\|8276089_8276527_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159510437.1\|8281153_8282065_+\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|224651
NZ_CP047146.1\|WP_159508559.1\|8266067_8266319_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508566.1\|8277311_8278175_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270408
NZ_CP047146.1\|WP_159508561.1\|8268249_8269947_+\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|223989
NZ_CP047146.1\|WP_159508560.1\|8266583_8268278_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NZ_CP047146.1\|WP_159510438.1\|8284813_8285023_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508573.1\|8285022_8285301_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508568.1\|8278934_8280218_+\|Cmx/CmrA-family-chloramphenicol-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP047146.1\|WP_159508572.1\|8283135_8284758_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|181971
NZ_CP047146.1\|WP_159508562.1\|8271938_8272190_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508563.1\|8274970_8275693_-\|copper-homeostasis-protein-CutC	unknown	unknown	gnl\|CDD\|225684
NZ_CP047146.1\|WP_159508557.1\|8264763_8265606_-\|phage-major-capsid-protein	unknown	unknown	gnl\|CDD\|377449
NZ_CP047146.1\|WP_159508571.1\|8282130_8283084_+\|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl\|CDD\|235467
NZ_CP047146.1\|WP_159508570.1\|8280568_8280931_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP047146.1\|WP_159508558.1\|8265631_8266075_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368031
NZ_CP047146.1\|WP_159510436.1\|8270231_8271413_-\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|172015

Protein	Function_ID	Function_description	E-value
NZ_CP047146.1\|WP_159508569.1\|8280297_8280567_-\|DUF4031-domain-containing-protein	gnl\|CDD\|379076	pfam13223, DUF4031, Protein of unknown function (DUF4031). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	4.1512e-32
NZ_CP047146.1\|WP_159508567.1\|8278186_8278837_+\|hypothetical-protein	gnl\|CDD\|226789	COG4339, COG4339, Uncharacterized protein conserved in bacteria [Function unknown].	5.50128e-48
NZ_CP047146.1\|WP_159510436.1\|8270231_8271413_-\|DUF2029-domain-containing-protein	gnl\|CDD\|172015	PRK13375, pimE, mannosyltransferase; Provisional.	3.9421e-52
NZ_CP047146.1\|WP_159510437.1\|8281153_8282065_+\|SIS-domain-containing-protein	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	3.56738e-67
NZ_CP047146.1\|WP_159508566.1\|8277311_8278175_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.74298e-69
NZ_CP047146.1\|WP_159508568.1\|8278934_8280218_+\|Cmx/CmrA-family-chloramphenicol-efflux-MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	3.77977e-80
NZ_CP047146.1\|WP_159508560.1\|8266583_8268278_-\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	2.48171e-40
NZ_CP047146.1\|WP_159508572.1\|8283135_8284758_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|181971	PRK09586, murP, PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed.	2.19749e-108
NZ_CP047146.1\|WP_159508571.1\|8282130_8283084_+\|N-acetylmuramic-acid-6-phosphate-etherase	gnl\|CDD\|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	1.57379e-154
NZ_CP047146.1\|WP_159508563.1\|8274970_8275693_-\|copper-homeostasis-protein-CutC	gnl\|CDD\|225684	COG3142, CutC, Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism].	6.00368e-24
NZ_CP047146.1\|WP_159508557.1\|8264763_8265606_-\|phage-major-capsid-protein	gnl\|CDD\|377449	pfam05065, Phage_capsid, Phage capsid family. Family of bacteriophage hypothetical proteins and capsid proteins.	6.44768e-28
NZ_CP047146.1\|WP_159508561.1\|8268249_8269947_+\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	2.16644e-108
NZ_CP047146.1\|WP_159508558.1\|8265631_8266075_-\|hypothetical-protein	gnl\|CDD\|368031	pfam04636, PA26, PA26 p53-induced protein (sestrin). PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.	0.00704357

>NZ_CP047146.1|WP_159508564.1|8276089_8276527_+|hypothetical-protein
MAANSLGASVLTAAQDLIAERTVTAGEGFFRRLLHRRDDTDLGDDTAGPLLDTRRADALDALLATLDDHDRRLLATAVAAWLRSPAGQRDAEEFRDQVTRLASVTGPQTVHYTPTATGQGSIAAVEIHGNITMGGSPRPQDEDDA
>NZ_CP047146.1|WP_159508563.1|8274970_8275693_-|copper-homeostasis-protein-CutC
MNQRALLEVIALGPQDAVAARAGGADRLELVTDMAADGLTPPRATFAAIRAAVDLPLRVMLRAADGFAAGDVDALCAEAAALRAEGAEEFVLGFLTPDGRVDLAAVGALAEVIDGCRWTFHRAIDRAADRDALRAELAGCGRSAGLDTYLTAGSAQGVDEGLATLVAEQARTDAGEAGYAPRILVGGGLRLEHLPELRAAGLNAFHIGGAARPGGWAAPVEAAAVREWRAALDLPVVQQV
>NZ_CP047146.1|WP_159508562.1|8271938_8272190_-|hypothetical-protein
MSSATISSASVASISSISSTASSSAHPVSRHPVKGATALGPDPSGGMTAAHGHRHLAGNALRAVKVFAAAAFSVVVMGEYAEG
>NZ_CP047146.1|WP_159510436.1|8270231_8271413_-|DUF2029-domain-containing-protein
MSDIVVYRAEGHAAATGGDLYGFTVTKWALPATYPPFAALLFIPTTWISLTTLKVACILVNAALLALLIHLSCKAAGLRKAAYTAPVILAATAFGLWLEPVFQTFVFGQVNLALTCLVLWDLSRPDGARFKGFATGIAAGIKLTPAIFAVYLLITGRVKAAFTALAGFVVSVLLGALVLPGASVEFWTRRMFETQRVGKVWIVDNQSLQGLVARLLHTTEPGIWWMAAAGITAVFGLWAARRVYIRRGQDNWGVLATAVTALLVSPISWSHHWVWCVPLLVALAAHTRRVPWRRALTAAVAVAFTARSMWALHHRGERALHFDWWQQLLAAPYPLIGLALLVALAWWTRRAPDAPARPRSGIREGTRGSGRGRSGIPQPRVDQRLRTRSRAAG
>NZ_CP047146.1|WP_159508561.1|8268249_8269947_+|DEAD/DEAH-box-helicase-family-protein
MSCLIVQSDKTLLLEVDHELADDCRRAIAPFAELERAPEHIHTYRVTPLGLWNARAAGHDAEQVVDALVQFSRYPVPHALLVDVAETMSRYGRLTLTKHPAHGLVLSTTDRPVLEEILRSKKVQPLVGARIDPDTVAVHPSERGQIKQTLLKLGWPAEDLAGYVDGEAHPIHLEENGWALRPYQQQAVEGFWHGGSGVVVLPCGAGKTLVGAGAMAQAKATTLILVTNTVSARQWKHELVKRTSLTEDEIGEYSGTKKEIRPVTIATYQVLTTKRKGVYPHLELFDSRDWGLIVYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDSERLAYATAETEEKYRFCATTDSKQRVTEALVRRHHGEQTLVIGQYIDQLDELGEHLEAPVIKGETTNAQREKLFNAFREGEISVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHEARFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIVDADELLAAGGADPAGEDEPAGEDDPAPA
>NZ_CP047146.1|WP_159508560.1|8266583_8268278_-|recombinase-family-protein
MSLWTIKQDTHTSVDRIAQVTDTVPAQVRAMPRARRRKGVSADAPGMRAALYVRLSRETEESTSPERQRAACEALCEARGWKIVAIEEDIDVSGYSRGLDRPGLQRILARLAEFDVIVFFKIDRLARSTVDFAEIMKITQNEGVALASASEPLDLTSSMGRAMAKVIAVFAELESDTIGMRVSNAHEHLRREGRWTGGRVPYGYQVAPNPDGPGRVLVINPEEAKTVREIVERVLAKDSLMKIATDLSKADIPSPGHSSRRSTGKNSNSKQWYTTTLKSLLTNPQLLGQVIEDGKPILRTDGLPLVSRPPVLDMDTWHALQDELKRRAGAGDQRRHGTSLLRTVLYCGVCHSRMYTFTSRGKLRYRCIGRLKQRQRTGEQGTCYGPSVPAEHTEAHVTELFLEKLGGAEVVRMVEHAGEDFRPQIRQAEEALSDLEKDRYERGLFKGDDGAKRYADQYAKLEDRLASLKNMQRNAKPAGVEAVPTGQTYGDLWEAASVEGKRDLLLDAGAYVEVAPAKRGARRLDTSRLAVFFGDEGRIRRAAADGKDVEEIVRGVVATELEMV
>NZ_CP047146.1|WP_159508559.1|8266067_8266319_-|hypothetical-protein
MILDRINLSRRLIAALSDAIWLAAETGMHDRTPSFSELRERAAKELGEVVRNAYNNGGITEAQAKAAMRPIYSTANEVHRGGA
>NZ_CP047146.1|WP_159508558.1|8265631_8266075_-|hypothetical-protein
MPEQAETAMDPALTAPEMEVAPEASEDVTDPAGSDTASGVDALQARVRELETERDRLAVEKAGRDHADAVATIVNRFTYVTEEIVQALPDGLPVERLEAMAESLNKAIPTAMNRAWNERASDGMGKGGLDPTQPPGATWDRLFRTKL
>NZ_CP047146.1|WP_159508557.1|8264763_8265606_-|phage-major-capsid-protein
MALFTNIAGVSGITPDDYGPLIIEPVERQSVALQVASTLKTSSTKVHIPIVHTDAGASFVAEGEEIAPTDATLGELEVMPAKCAGLSIISSELAEDSDPDAQKLVGDGLARSIARILDQSFFGSLPIPAPQGLEAVDGVGTVDAGSKFANLDAFQEAINRAEDVGATITAFAANPADALTLAKLKQAKDSNVPLLGSDPTTPTRRTVLGVPLYVSNAVTAGTVWGIPRDRVMVVMRRNVTLDVSKHARFTSDQVAIKATLRAAHAFPHPAAIQRVSLSKA
>NZ_CP047146.1|WP_159508556.1|8263412_8263982_+|hypothetical-protein
MENRIAAIDAMVDNATCVVSASDGAILEIVAKAVQSGASATFYVSRSQAKAINAWYWTPERRKQLGVEDVSPEELHKIEEELGLKDVIAFSNRIPCEKCGHVYGAFEFLQQGIREHGRAGLEAVLGMENTSLIRVNPSEVPVCPNCGENVTDSGGASGERIIGGTPDGPPPGAHWYGGTSAYAGCCRAA
>NZ_CP047146.1|WP_159508566.1|8277311_8278175_+|transporter-substrate-binding-domain-containing-protein
MITTRTTKLAALLAVTALTAAACGSSEPPSLFASGKVSVGAKNDQPGTGVVHNYKFSGFDITVAQQILKSVGAEPDFGIVPSEDRAAVLADKKKDLVIATFSITVDRMKELDFAGPYASTYQGLMVRKNDNRIRKPSDLAGKRVCTWPGTTSATTLKGPDGNHIAVYEAPDASSCITDLKTKKVADAVSTDQMILYGFTQENPDLKVVPDITFGSANHYGIAMAKGHRNDCLKLRDALREYVTNNDWSHDFTTSLPSIPAADPTWETDFKPRVETIDSLSCRDTPRT
>NZ_CP047146.1|WP_159508567.1|8278186_8278837_+|hypothetical-protein
MAPMTTLASRWATTVANARAPQAGPDPAPYATNLLARWDEPQRHYHTTDHLAAVLDRIDELADHAEDLPAVQLAAWFHDAVYRPDRSENEERSAALAERALPELGIGAPRTAEVARLVRLTVTHDPADGDRNGEVLCDADLAVLAGSPDRYAAYAAAVRAEYAFVPEPAFRTGRAAVLRQLLALPRLFTTPHGQDHWEQPARHNLTTELSLLTTGT
>NZ_CP047146.1|WP_159508568.1|8278934_8280218_+|Cmx/CmrA-family-chloramphenicol-efflux-MFS-transporter
MPAPADRSRLPISVYVLGLSVFALGTSEFMLSGILQPLARDLQVSIPQAGLLVSAFAIGMVVGAPVLAAATLRLPRRTTLIALLAVFGLGQAAGALAPSYAVLFASRVISALACAGFWAVGAAVAVSLVPVTARARAMAVMVGGLSIANIAGVPAGALLGQHAGWRSAFWAVAALSVVGLVGVIALVPYTAVPTGEDRPQLRRELSIYKDKQVWLALIATAMNGAAVFALFSYLSPLLTETAGLAESWVPTVLALFGVGALIGTFIGGRIADAHLFGTLFAGISASTAVLALLALTAHSPVAAVGLSLMLGVTAFTTAPALNARMFNVANAAPTLAGATTTAAFNVGNTLGPWLGGLAISAGWGYPSVAWTGAALAAVAVATTAVAFRLHRATAQSRLIASSSPSPSPTPSPTPAPTTPTPQTANRY
>NZ_CP047146.1|WP_159508569.1|8280297_8280567_-|DUF4031-domain-containing-protein
MAIYIDPPMWPGHGRMWSHLVSDRSFDELHRFAAEIGAPPRAFERDHYDLPAERYGDAVRAGAVEVGSKELVRRLTEAGLRRPKGRPGA
>NZ_CP047146.1|WP_159508570.1|8280568_8280931_-|hypothetical-protein
MELEQALHTARALVLADLIADEVADADIVSLVEDAVSHRRWWVEQWPDGAAFLAGLIAQDVQDALLERYGRWPLCPVCIESGDPHALDVEPELGPDPHWVCPKTAVAVAPVGRLRAPAEG
>NZ_CP047146.1|WP_159510437.1|8281153_8282065_+|SIS-domain-containing-protein
MRPASRSAPASPAPAALAAKVRTLAPTMTRSMQRVAEAVASDPAGCAALTVTGLAERTGTSEATVVRTSRLLGYPGYRDLRLALAALAAQQAAGSAPAVTADIAVDDSLIDVVAKLAQEERQCLADTAAALDVTQLEAAVAALAAARRIDVYGIGASNLVAQDLVQKLLRIGLIAHAHSDPHLAVTNAVQMRARDVAIAITHSGRTTDVIEPLRVAFDHGATTIAITGRPDGEIAAYADHILTTSTARESELRPAAMSSRTSQLLVVDCLFIGVAQRTYETAAPALSASYEALAHRHSPRTGH
>NZ_CP047146.1|WP_159508571.1|8282130_8283084_+|N-acetylmuramic-acid-6-phosphate-etherase
MTSPAAHDPSYATLRAQLDALTTEAFRPDLAEIDRRSTLEIARTMNGEDATVPAAVAARLPEIAAAVDAIAARMARGGRLIYAGAGTAGRLGVLDASECPPTFNTDPSEVLGLIAGGPTAMVSAVEGAEDSKELAVEDLTAIAVADRDTVVGISASGRTPYAIGAVEHARAIGALTIGLSCNADSALAAAAEHGIEIVVGPELLTGSTRLKAGTAQKLVLNMLSTITMIRLGKTYGNLMVDVRASNEKLRARSRRIVALATGATDLEIEAALAETDGEVKNAILVLLGGVDGRRAAGLLRSSRGHLRAALQSAHPAN
>NZ_CP047146.1|WP_159508572.1|8283135_8284758_+|PTS-transporter-subunit-EIIC
MTEDKNRATAAAILPLVGGARNITSIAHCMTRLRLGIRDRSLVQDEALKALPAVLGVVEDDTYQIVLGPGTVARVTPELERLAANDSTPTPQPDAPTAPHPGAHIGPEDTPQPAPGPAPTAPAPTAADLAAQGAVLKARQKARNATPVKLFLRRIADIFVPLIPALIGCGIIAGVNGLLTNAGWLPALVPALTAIASGFMSLIAVFVGYNTAKEFGGTPVLGGAVTAVIVFPGVANITAFGQKLSPGQGGVLGALAAALLAAQLEKQLRRRIPEALDVLLTPTLTVLLTGLITVFGLMYAAGEVATAIGAFATWLLAHGGAVAGFLLGGLFLPLVMLGLHQALIPIHTTLIQQQGYTVLLPILAMAGAGQVGAALAVYVRLPRNGSIRTTIKSALPAGFLGVGEPLIYGVSLPLGRPFITACIGGAFGGGTVGLFNQLGDAVGSTAIGPSGWALFPLVKGNHPLGTTVAVYALGLAIGYAVGFVATYLFGFSRQMRTDLNADPQPTDPAASGAREAGTAAPTVPHRGSLDAAHAPLQDAG
>NZ_CP047146.1|WP_159510438.1|8284813_8285023_-|hypothetical-protein
MPAVGSYAMDGRDGRIGRVSGHRGPFVQLRPPGGGAEWNCPPGLLRAAPRCAALAARLRDLNWQSSRIP
>NZ_CP047146.1|WP_159508573.1|8285022_8285301_-|hypothetical-protein
MVEVLTASEREQAAEQATAELDSALRAVGVALPSLCVDQVSAASTFMAPLVELGRCNVETARRLAEVLAEYAKGAAYGHDARDGQGPEGRRR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP047146_10	10.3\|6544298\|17\|NZ_CP047146\|CRISPRCasFinder	6544298-6544314	17	NZ_CP047146.1	2718215-2718231	1	0.941
NZ_CP047146_10	10.3\|6544298\|17\|NZ_CP047146\|CRISPRCasFinder	6544298-6544314	17	NZ_CP047146.1	3878849-3878865	1	0.941
NZ_CP047146_10	10.3\|6544298\|17\|NZ_CP047146\|CRISPRCasFinder	6544298-6544314	17	NZ_CP047146.1	8565919-8565935	1	0.941
NZ_CP047146_10	10.3\|6544298\|17\|NZ_CP047146\|CRISPRCasFinder	6544298-6544314	17	NZ_CP047146.1	8582990-8583006	1	0.941
NZ_CP047146_9	9.1\|5605254\|40\|NZ_CP047146\|CRISPRCasFinder	5605254-5605293	40	NZ_CP047146.1	2175236-2175275	2	0.95

1. spacer 10.3|6544298|17|NZ_CP047146|CRISPRCasFinder matches to position: 2718215-2718231, mismatch: 1, identity: 0.941

gacgccgcctccgcggc	CRISPR spacer
gacgccgcctccgccgc	Protospacer
************** **

2. spacer 10.3|6544298|17|NZ_CP047146|CRISPRCasFinder matches to position: 3878849-3878865, mismatch: 1, identity: 0.941

gacgccgcctccgcggc	CRISPR spacer
gacgccacctccgcggc	Protospacer
******.**********

3. spacer 10.3|6544298|17|NZ_CP047146|CRISPRCasFinder matches to position: 8565919-8565935, mismatch: 1, identity: 0.941

gacgccgcctccgcggc	CRISPR spacer
gacgcggcctccgcggc	Protospacer
***** ***********

4. spacer 10.3|6544298|17|NZ_CP047146|CRISPRCasFinder matches to position: 8582990-8583006, mismatch: 1, identity: 0.941

gacgccgcctccgcggc	CRISPR spacer
gacgcctcctccgcggc	Protospacer
****** **********

5. spacer 9.1|5605254|40|NZ_CP047146|CRISPRCasFinder matches to position: 2175236-2175275, mismatch: 2, identity: 0.95

tcggctgtcccgccgtaggggtttgtcgccgttgcgcggc	CRISPR spacer
tcggctttcccgccgtgggggtttgtcgccgttgcgcggc	Protospacer
****** *********.***********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP047146_5	5.1\|1665098\|48\|NZ_CP047146\|CRISPRCasFinder	1665098-1665145	48	NZ_CP018784	Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence	253740-253787	6	0.875
NZ_CP047146_5	5.1\|1665098\|48\|NZ_CP047146\|CRISPRCasFinder	1665098-1665145	48	KY250482	Corynebacterium phage phi16, complete genome	56101-56148	9	0.812
NZ_CP047146_5	5.1\|1665098\|48\|NZ_CP047146\|CRISPRCasFinder	1665098-1665145	48	KF017927	Mycobacterium phage Odin, complete genome	4126-4173	9	0.812
NZ_CP047146_5	5.1\|1665098\|48\|NZ_CP047146\|CRISPRCasFinder	1665098-1665145	48	MN284903	Mycobacterium phage GaugeLDP, complete genome	5561-5608	9	0.812
NZ_CP047146_5	5.1\|1665098\|48\|NZ_CP047146\|CRISPRCasFinder	1665098-1665145	48	MK359341	Mycobacterium phage GingkoMaracino, complete genome	3702-3749	10	0.792
NZ_CP047146_5	5.1\|1665098\|48\|NZ_CP047146\|CRISPRCasFinder	1665098-1665145	48	MH536825	Mycobacterium phage Ollie, complete genome	3702-3749	10	0.792
NZ_CP047146_5	5.1\|1665098\|48\|NZ_CP047146\|CRISPRCasFinder	1665098-1665145	48	MN284900	Mycobacterium phage JeppNRM, complete genome	3867-3914	10	0.792
NZ_CP047146_5	5.1\|1665098\|48\|NZ_CP047146\|CRISPRCasFinder	1665098-1665145	48	MH450128	Mycobacterium phage Reba, complete genome	3540-3587	10	0.792
NZ_CP047146_5	5.1\|1665098\|48\|NZ_CP047146\|CRISPRCasFinder	1665098-1665145	48	MH371121	Mycobacterium phage Phranny, complete genome	3867-3914	10	0.792
NZ_CP047146_5	5.1\|1665098\|48\|NZ_CP047146\|CRISPRCasFinder	1665098-1665145	48	KF279418	Mycobacterium phage Anubis, complete genome	3702-3749	10	0.792

1. spacer 5.1|1665098|48|NZ_CP047146|CRISPRCasFinder matches to NZ_CP018784 (Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence) position: , mismatch: 6, identity: 0.875

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ttgatcccctgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
*.*.**************************..**************.

2. spacer 5.1|1665098|48|NZ_CP047146|CRISPRCasFinder matches to KY250482 (Corynebacterium phage phi16, complete genome) position: , mismatch: 9, identity: 0.812

---tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
caattgatcat---tagctcaattggcagagcatccggctgttaaccggac	Protospacer
   *.*.** .   ********************.***************

3. spacer 5.1|1665098|48|NZ_CP047146|CRISPRCasFinder matches to KF017927 (Mycobacterium phage Odin, complete genome) position: , mismatch: 9, identity: 0.812

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccaatgacgtgtagctcaattggcagagcacccggctgttaaccggac	Protospacer
.*..*  * *********************..***************

4. spacer 5.1|1665098|48|NZ_CP047146|CRISPRCasFinder matches to MN284903 (Mycobacterium phage GaugeLDP, complete genome) position: , mismatch: 9, identity: 0.812

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccactgacgtgtagctcaatcggcagagcatccggctgttaaccggac	Protospacer
.*. *  * ***********.**********.***************

5. spacer 5.1|1665098|48|NZ_CP047146|CRISPRCasFinder matches to MK359341 (Mycobacterium phage GingkoMaracino, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccactgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************.

6. spacer 5.1|1665098|48|NZ_CP047146|CRISPRCasFinder matches to MH536825 (Mycobacterium phage Ollie, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccactgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************.

7. spacer 5.1|1665098|48|NZ_CP047146|CRISPRCasFinder matches to MN284900 (Mycobacterium phage JeppNRM, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccattgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************.

8. spacer 5.1|1665098|48|NZ_CP047146|CRISPRCasFinder matches to MH450128 (Mycobacterium phage Reba, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccattgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************.

9. spacer 5.1|1665098|48|NZ_CP047146|CRISPRCasFinder matches to MH371121 (Mycobacterium phage Phranny, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccattgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************.

10. spacer 5.1|1665098|48|NZ_CP047146|CRISPRCasFinder matches to KF279418 (Mycobacterium phage Anubis, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccactgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1872975 : 1937571

uncultured_Mediterranean_phage(33.33%)

transposase,integrase

attL 1897719:1897778|attR 1935740:1936659

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159509817.1\|1872975_1873182_+\|integrase	integrase	NA	NA	NA	NA
WP_159504054.1\|1873202_1873721_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_159509818.1\|1874215_1875406_+	protein kinase	A0A2K9L4T9	Tupanvirus	7.8e-10	23.8
WP_159509819.1\|1875649_1878631_+	DEAD/DEAH box helicase family protein	A0A1B1IUI1	uncultured_Mediterranean_phage	2.5e-33	24.8
WP_159504055.1\|1878627_1884225_+	hypothetical protein	NA	NA	NA	NA
WP_159504056.1\|1884221_1890995_+	DEAD/DEAH box helicase	A0A1B1IUF6	uncultured_Mediterranean_phage	1.2e-59	23.4
WP_159504057.1\|1890991_1893301_+	UvrD-helicase domain-containing protein	NA	NA	NA	NA
WP_159504058.1\|1893365_1894433_-	hypothetical protein	NA	NA	NA	NA
WP_159504059.1\|1894551_1895490_-	hypothetical protein	NA	NA	NA	NA
WP_159504060.1\|1896216_1896456_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
1897719:1897778	attL	NA	NA	NA	NA
WP_159503645.1\|1897725_1898544_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_159504061.1\|1899095_1899437_-	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase	NA	NA	NA	NA
WP_159504062.1\|1899436_1899961_-	hypothetical protein	NA	NA	NA	NA
WP_159504063.1\|1899998_1901090_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_159504064.1\|1901086_1901887_-	diaminopimelate epimerase	NA	NA	NA	NA
WP_159504065.1\|1902277_1902820_-	NUDIX hydrolase	NA	NA	NA	NA
WP_159504066.1\|1902816_1903206_-	hypothetical protein	NA	NA	NA	NA
WP_159504067.1\|1903298_1904144_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159509820.1\|1904171_1904618_-	hypothetical protein	NA	NA	NA	NA
WP_159504068.1\|1904661_1904892_-	hypothetical protein	NA	NA	NA	NA
WP_159504069.1\|1905241_1906438_-	amidohydrolase family protein	NA	NA	NA	NA
WP_159504070.1\|1906434_1907559_-	hypothetical protein	NA	NA	NA	NA
WP_159504071.1\|1907567_1908083_-	hypothetical protein	NA	NA	NA	NA
WP_159504072.1\|1908153_1908609_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159504073.1\|1909161_1909488_+	transcriptional regulator	NA	NA	NA	NA
WP_159509821.1\|1909489_1910509_+	hypothetical protein	A0A193GZ86	Enterobacter_phage	3.6e-11	34.7
WP_159504074.1\|1910508_1911216_+	ATP-binding protein	A0A1B1P7U2	Bacillus_phage	1.2e-13	35.9
WP_159504075.1\|1911332_1911899_+	WhiB family transcriptional regulator	NA	NA	NA	NA
WP_159504076.1\|1911895_1912933_+	DUF2637 domain-containing protein	NA	NA	NA	NA
WP_067357825.1\|1913035_1913260_+	hypothetical protein	NA	NA	NA	NA
WP_159504077.1\|1913256_1913913_+	plasmid mobilization relaxosome protein MobC	NA	NA	NA	NA
WP_159504078.1\|1913912_1915679_+	relaxase/mobilization nuclease domain-containing protein	NA	NA	NA	NA
WP_159504079.1\|1915785_1916187_+	hypothetical protein	NA	NA	NA	NA
WP_159504080.1\|1916309_1917581_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.0e-31	35.8
WP_159504081.1\|1918002_1918647_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_159509822.1\|1918861_1919233_+	hypothetical protein	NA	NA	NA	NA
WP_159504082.1\|1919578_1919908_-	esterase	NA	NA	NA	NA
WP_159504083.1\|1919999_1920212_-	hypothetical protein	NA	NA	NA	NA
WP_159504084.1\|1920265_1920538_-	hypothetical protein	NA	NA	NA	NA
WP_159504085.1\|1921389_1921662_+	hypothetical protein	NA	NA	NA	NA
WP_159504086.1\|1922993_1923794_+	hypothetical protein	NA	NA	NA	NA
WP_159509823.1\|1924573_1924732_+	hypothetical protein	NA	NA	NA	NA
WP_159504087.1\|1924778_1925123_-	hypothetical protein	NA	NA	NA	NA
WP_159504088.1\|1927501_1928446_-	DUF317 domain-containing protein	NA	NA	NA	NA
WP_159504089.1\|1928567_1929410_-	hypothetical protein	NA	NA	NA	NA
WP_159504090.1\|1929466_1930009_-	hypothetical protein	NA	NA	NA	NA
WP_159504091.1\|1930030_1930864_-	hypothetical protein	NA	NA	NA	NA
WP_159504092.1\|1930860_1931529_-	hypothetical protein	NA	NA	NA	NA
WP_159504093.1\|1931525_1932002_-	hypothetical protein	NA	NA	NA	NA
WP_159504094.1\|1931998_1932604_-	DUF4913 domain-containing protein	NA	NA	NA	NA
WP_159509824.1\|1933075_1934206_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_159504095.1\|1934202_1935750_+	hypothetical protein	NA	NA	NA	NA
WP_159503645.1\|1935746_1936565_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_159509825.1\|1936857_1937571_+\|transposase	transposase	NA	NA	NA	NA
1935740:1936659	attR	NA	NA	NA	NA

DBSCAN-SWA_2

4350397 : 4367466

Staphylococcus_phage(50.0%)

transposase,integrase

attL 4357181:4357196|attR 4370942:4370957

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159505864.1\|4350397_4350805_+\|transposase	transposase	NA	NA	NA	NA
WP_159510085.1\|4351857_4353024_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	6.7e-30	31.9
WP_159505865.1\|4353321_4353486_+	hypothetical protein	NA	NA	NA	NA
WP_159505866.1\|4353578_4354622_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_159510086.1\|4354782_4355268_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_159505867.1\|4355530_4355983_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_159505868.1\|4356082_4357300_+	MFS transporter	NA	NA	NA	NA
4357181:4357196	attL	NA	NA	NA	NA
WP_159505869.1\|4357473_4359069_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_159510087.1\|4359173_4359656_-	hypothetical protein	NA	NA	NA	NA
WP_159505870.1\|4359781_4360273_-	hypothetical protein	NA	NA	NA	NA
WP_159505871.1\|4360320_4362726_-	hypothetical protein	NA	NA	NA	NA
WP_159505872.1\|4362722_4363073_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159505873.1\|4363084_4364191_-\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	8.1e-09	28.5
WP_159505874.1\|4364256_4364553_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_159505875.1\|4364592_4365252_-	hypothetical protein	NA	NA	NA	NA
WP_159505876.1\|4365306_4365885_-	hypothetical protein	NA	NA	NA	NA
WP_159510088.1\|4366344_4367466_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
4370942:4370957	attR	NA	NA	NA	NA

DBSCAN-SWA_3

4478304 : 4537902

Mycobacterium_phage(60.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159505969.1\|4478304_4479138_+\|transposase	transposase	NA	NA	NA	NA
WP_159505970.1\|4479241_4480222_-	alpha/beta hydrolase fold domain-containing protein	NA	NA	NA	NA
WP_159505971.1\|4480344_4480746_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_159510097.1\|4481239_4481500_-	hypothetical protein	NA	NA	NA	NA
WP_159510098.1\|4483006_4484548_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_159505972.1\|4484817_4486074_+	hypothetical protein	NA	NA	NA	NA
WP_159505973.1\|4486391_4486928_-	hypothetical protein	NA	NA	NA	NA
WP_159505974.1\|4487211_4487469_-	hypothetical protein	NA	NA	NA	NA
WP_159505975.1\|4487857_4488112_+	hypothetical protein	NA	NA	NA	NA
WP_159505976.1\|4488284_4488809_-	ATP-binding protein	NA	NA	NA	NA
WP_159505977.1\|4488979_4489270_-	hypothetical protein	NA	NA	NA	NA
WP_159505978.1\|4489699_4489936_-	hypothetical protein	NA	NA	NA	NA
WP_159505979.1\|4490196_4491762_+	hypothetical protein	NA	NA	NA	NA
WP_159505980.1\|4492201_4492861_+	hypothetical protein	NA	NA	NA	NA
WP_159505815.1\|4492912_4493212_+\|transposase	transposase	Q9ETV7	Enterobacteria_phage	4.1e-08	40.0
WP_159505981.1\|4493208_4493829_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_159505982.1\|4495298_4495547_+\|transposase	transposase	A0A1P8CWQ3	Bacillus_phage	2.7e-05	41.4
WP_159505983.1\|4495641_4495869_-	hypothetical protein	NA	NA	NA	NA
WP_159505984.1\|4496090_4496222_-	hypothetical protein	NA	NA	NA	NA
WP_159505985.1\|4496270_4496465_-	hypothetical protein	NA	NA	NA	NA
WP_159510099.1\|4496530_4497451_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_159505986.1\|4497640_4497793_+	hypothetical protein	NA	NA	NA	NA
WP_159505987.1\|4497844_4498243_-	VOC family protein	NA	NA	NA	NA
WP_159505988.1\|4498336_4499326_+	WYL domain-containing protein	NA	NA	NA	NA
WP_159505989.1\|4499783_4500140_-	hypothetical protein	NA	NA	NA	NA
WP_159505990.1\|4500685_4501081_-	DUF4440 domain-containing protein	NA	NA	NA	NA
WP_159505991.1\|4501672_4501993_-	hypothetical protein	NA	NA	NA	NA
WP_159505992.1\|4502732_4502912_-	hypothetical protein	NA	NA	NA	NA
WP_159505993.1\|4503072_4503402_+	hypothetical protein	NA	NA	NA	NA
WP_159505994.1\|4503865_4505578_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159505995.1\|4505577_4506165_+	transcriptional regulator	NA	NA	NA	NA
WP_159510100.1\|4507569_4508688_-	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_159505996.1\|4508805_4509699_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_159505997.1\|4510571_4511150_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_159505998.1\|4511236_4512118_+	NAD-dependent epimerase/dehydratase family protein	NA	NA	NA	NA
WP_159505999.1\|4512363_4512537_-	PmrA	NA	NA	NA	NA
WP_159506000.1\|4516503_4516791_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159506001.1\|4516699_4517182_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159506002.1\|4518709_4519048_+	hypothetical protein	NA	NA	NA	NA
WP_159506003.1\|4520534_4520999_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_159506004.1\|4521054_4521897_-\|transposase	IS5 family transposase	A0A0M5M147	Mycobacterium_phage	5.1e-80	57.9
WP_159506005.1\|4522063_4522918_+	hypothetical protein	NA	NA	NA	NA
WP_159506006.1\|4522992_4523454_+	hypothetical protein	NA	NA	NA	NA
WP_159506007.1\|4523574_4524282_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159506008.1\|4524524_4525286_+	UTRA domain-containing protein	NA	NA	NA	NA
WP_159506009.1\|4525419_4526352_+	hypothetical protein	NA	NA	NA	NA
WP_159506010.1\|4527328_4527469_+	hypothetical protein	NA	NA	NA	NA
WP_159506011.1\|4528292_4528523_+	hypothetical protein	NA	NA	NA	NA
WP_159506012.1\|4528601_4528919_-	hypothetical protein	NA	NA	NA	NA
WP_159506013.1\|4529691_4530564_-	haloalkane dehalogenase	R9RXH6	Mycobacterium_phage	7.0e-08	29.3
WP_159506014.1\|4530596_4531001_-	pyridoxamine 5'-phosphate oxidase	NA	NA	NA	NA
WP_159506015.1\|4530997_4531690_-	NAD(P)H-binding protein	NA	NA	NA	NA
WP_159506016.1\|4531766_4532423_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_159506017.1\|4532566_4532743_-	hypothetical protein	NA	NA	NA	NA
WP_159510101.1\|4534002_4535364_+	cytochrome P450	V5UQK0	Mycobacterium_phage	3.8e-24	26.4
WP_159506018.1\|4535468_4536449_+	hypothetical protein	NA	NA	NA	NA
WP_159506019.1\|4536948_4537902_+\|transposase	IS481 family transposase	NA	NA	NA	NA

DBSCAN-SWA_4

4614090 : 4644736

uncultured_virus(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159510109.1\|4614090_4614564_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_159506070.1\|4615775_4616162_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_159506071.1\|4616173_4616344_-	hypothetical protein	NA	NA	NA	NA
WP_159506072.1\|4617064_4618441_+	S8 family serine peptidase	NA	NA	NA	NA
WP_159506073.1\|4618660_4619953_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	2.0e-35	37.8
WP_159506074.1\|4620100_4620565_-	hypothetical protein	NA	NA	NA	NA
WP_159506075.1\|4620907_4621072_-	hypothetical protein	NA	NA	NA	NA
WP_159506076.1\|4622784_4623009_+	hypothetical protein	NA	NA	NA	NA
WP_159506077.1\|4623095_4623428_+	esterase	NA	NA	NA	NA
WP_159506078.1\|4623671_4624583_+	restriction endonuclease	NA	NA	NA	NA
WP_159506079.1\|4624719_4625466_+	phosphotransferase	NA	NA	NA	NA
WP_159506080.1\|4625872_4626853_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159506081.1\|4626924_4627599_+	HD domain-containing protein	NA	NA	NA	NA
WP_159506082.1\|4627646_4628069_+	RidA family protein	NA	NA	NA	NA
WP_159506083.1\|4628329_4628608_+	hypothetical protein	NA	NA	NA	NA
WP_159503645.1\|4628680_4629499_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_159506084.1\|4629721_4631179_+\|transposase	transposase	NA	NA	NA	NA
WP_159506085.1\|4631407_4631821_-	hypothetical protein	NA	NA	NA	NA
WP_159506086.1\|4631929_4632607_+	hypothetical protein	NA	NA	NA	NA
WP_159510110.1\|4633785_4634082_-	hypothetical protein	NA	NA	NA	NA
WP_159506087.1\|4634283_4634787_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159506088.1\|4634744_4635335_+	hypothetical protein	NA	NA	NA	NA
WP_159506089.1\|4635492_4636731_+	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_159506090.1\|4636867_4638166_-	erythromycin esterase family protein	NA	NA	NA	NA
WP_159510111.1\|4638408_4639101_-	antibiotic acetyltransferase	M1HS53	Paramecium_bursaria_Chlorella_virus	7.5e-13	30.0
WP_159506091.1\|4639231_4640755_-	FAD-binding monooxygenase	NA	NA	NA	NA
WP_159506092.1\|4640894_4641485_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_159506073.1\|4641739_4643032_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	2.0e-35	37.8
WP_159506093.1\|4643203_4644736_+\|transposase	ISL3 family transposase	A9YX10	Burkholderia_phage	1.8e-11	30.3

DBSCAN-SWA_5

4676671 : 4712789

Orpheovirus(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159504108.1\|4676671_4678129_-\|transposase	transposase	NA	NA	NA	NA
WP_159506110.1\|4679369_4680047_-	response regulator	NA	NA	NA	NA
WP_159510112.1\|4680043_4681462_-	two-component sensor histidine kinase	NA	NA	NA	NA
WP_159506111.1\|4681920_4684044_+	hypothetical protein	NA	NA	NA	NA
WP_159506112.1\|4684069_4684393_-\|transposase	transposase	NA	NA	NA	NA
WP_159506113.1\|4684354_4684729_+	hypothetical protein	NA	NA	NA	NA
WP_159510113.1\|4684769_4685120_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_159506114.1\|4685408_4691588_+	DUF11 domain-containing protein	NA	NA	NA	NA
WP_159506115.1\|4691640_4691940_+	hypothetical protein	NA	NA	NA	NA
WP_159503645.1\|4692060_4692879_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_159503645.1\|4692981_4693800_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_159503645.1\|4694698_4695517_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_159506116.1\|4696871_4698329_-\|transposase	transposase	NA	NA	NA	NA
WP_159506117.1\|4698379_4698562_-	hypothetical protein	NA	NA	NA	NA
WP_159506118.1\|4699371_4700361_-	pirin family protein	NA	NA	NA	NA
WP_159506119.1\|4702419_4704039_-	protein kinase	A0A2I2L395	Orpheovirus	2.1e-13	25.1
WP_159506120.1\|4706001_4706220_+	hypothetical protein	NA	NA	NA	NA
WP_159510114.1\|4707400_4708063_+	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_159506121.1\|4708264_4709509_+	serine hydrolase	NA	NA	NA	NA
WP_159506122.1\|4709816_4709975_+	hypothetical protein	NA	NA	NA	NA
WP_159506123.1\|4710086_4710278_-	hypothetical protein	NA	NA	NA	NA
WP_159506124.1\|4710653_4711649_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_159506125.1\|4711835_4712789_+\|transposase	IS481 family transposase	NA	NA	NA	NA

DBSCAN-SWA_6

8053813 : 8127199

Klosneuvirus(16.67%)

holin,tRNA,plate,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_159508420.1\|8053813_8054827_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_159508421.1\|8054904_8056182_-	serine hydroxymethyltransferase	G9I092	Helicoverpa_zea_nudivirus	1.7e-87	45.2
WP_159508422.1\|8056462_8057668_+	ornithine--oxo-acid transaminase	A0A1V0SKB7	Klosneuvirus	8.7e-25	26.8
WP_159510414.1\|8058917_8059412_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_159508423.1\|8059850_8061383_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_159510415.1\|8061499_8061934_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_159508424.1\|8061938_8062388_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_159510416.1\|8062420_8063131_+	isocitrate lyase/phosphoenolpyruvate mutase family protein	NA	NA	NA	NA
WP_159508425.1\|8063810_8064560_+	serine hydrolase	NA	NA	NA	NA
WP_159508426.1\|8064615_8065800_-	hypothetical protein	NA	NA	NA	NA
WP_159508427.1\|8065928_8066222_-	hypothetical protein	NA	NA	NA	NA
WP_159508428.1\|8066491_8070766_+	amino acid adenylation domain-containing protein	A0A2K9KZV5	Tupanvirus	2.5e-50	26.9
WP_159508429.1\|8070774_8071521_+	hypothetical protein	A0A2H4N819	Lake_Baikal_phage	5.6e-14	37.1
WP_159508430.1\|8071641_8071851_+	hypothetical protein	NA	NA	NA	NA
WP_159510417.1\|8071864_8072356_+	hypothetical protein	NA	NA	NA	NA
WP_159508431.1\|8072352_8073186_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_159508432.1\|8073730_8074720_-	glycine/betaine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_159508433.1\|8074722_8076720_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_159508434.1\|8076886_8078074_-\|holin	betaine/proline/choline family ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.4e-27	39.0
WP_159508435.1\|8078073_8079615_-	oxidoreductase	A0A1V0SI18	Klosneuvirus	5.1e-110	42.6
WP_159508436.1\|8079684_8081202_-	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_159508437.1\|8081424_8082216_+	hypothetical protein	NA	NA	NA	NA
WP_159508438.1\|8082296_8082506_+	hypothetical protein	NA	NA	NA	NA
WP_159510418.1\|8082563_8083199_-	hypothetical protein	NA	NA	NA	NA
WP_159510419.1\|8083589_8083940_-	hypothetical protein	NA	NA	NA	NA
WP_159510420.1\|8083998_8085705_-	hypothetical protein	NA	NA	NA	NA
WP_159508439.1\|8086139_8087129_-	malate dehydrogenase	NA	NA	NA	NA
WP_159508440.1\|8087560_8088781_-	NADP-dependent isocitrate dehydrogenase	NA	NA	NA	NA
WP_159508441.1\|8088920_8089349_-	DUF3017 domain-containing protein	NA	NA	NA	NA
WP_159508442.1\|8089398_8090256_-	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	A0A249XZQ2	Enterococcus_phage	4.6e-28	35.2
WP_159508443.1\|8090503_8091256_+	RDD family protein	NA	NA	NA	NA
WP_159508444.1\|8091464_8092037_+	hypothetical protein	NA	NA	NA	NA
WP_159508445.1\|8092123_8093692_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	9.8e-61	42.5
WP_159508446.1\|8093688_8094333_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.6e-20	34.4
WP_159508447.1\|8095117_8095513_+	hypothetical protein	NA	NA	NA	NA
WP_159508448.1\|8095540_8097205_-	hypothetical protein	NA	NA	NA	NA
WP_159508449.1\|8097303_8098212_+	hypothetical protein	NA	NA	NA	NA
WP_159508450.1\|8098303_8099188_-	succinate--CoA ligase subunit alpha	NA	NA	NA	NA
WP_159508451.1\|8099209_8100388_-	ADP-forming succinate--CoA ligase subunit beta	NA	NA	NA	NA
WP_159508452.1\|8101165_8103013_+\|tail	phage tail protein	J9PVC2	Bacillus_phage	6.4e-43	34.4
WP_159508453.1\|8103091_8103616_+\|tail	phage tail protein	NA	NA	NA	NA
WP_159508454.1\|8103722_8104478_+	hypothetical protein	NA	NA	NA	NA
WP_159508455.1\|8104470_8105304_+	hypothetical protein	NA	NA	NA	NA
WP_159508456.1\|8105521_8106550_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_159510421.1\|8106583_8108623_+	AAA family ATPase	A0A109WUE1	Acidianus_tailed_spindle_virus	9.6e-08	34.1
WP_159510422.1\|8108739_8108997_+	hypothetical protein	NA	NA	NA	NA
WP_159508457.1\|8108993_8115812_+	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_159508458.1\|8115816_8116386_+	hypothetical protein	NA	NA	NA	NA
WP_159508459.1\|8116430_8117102_+	hypothetical protein	NA	NA	NA	NA
WP_159508460.1\|8117105_8117489_+	hypothetical protein	NA	NA	NA	NA
WP_159508461.1\|8117481_8118624_+	hypothetical protein	NA	NA	NA	NA
WP_159508462.1\|8118748_8119273_+\|plate	baseplate assembly protein	NA	NA	NA	NA
WP_159508463.1\|8119297_8119672_+	hypothetical protein	NA	NA	NA	NA
WP_159508464.1\|8119668_8120055_+	hypothetical protein	NA	NA	NA	NA
WP_159508465.1\|8120051_8123276_+\|plate	putative baseplate assembly protein	A0A1J0GW37	Streptomyces_phage	1.4e-13	26.8
WP_159508466.1\|8123272_8127199_+\|plate	putative baseplate assembly protein	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP047146

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection