CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP040438	Stenotrophomonas maltophilia strain PEG-173 chromosome, complete genome	13 crisprs	csa3,cas3,DEDDh,WYL,Cas9_archaeal,PD-DExK,DinG	1	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP040438_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_1

161277-161382

Orphan

Consensus_repeat	Method
GTGGGTGCCGACCATTGGTCGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040438_1

>merge|NZ_CP040438|1|161277-161382|CRISPRCasFinder
GTGGGTGCCGACCATTGGTCGGCACTTCTACTGTTCTGGTGGGTGCCAAGCTTGCTTGGCACTGGGTCTGGGTCTGCTCTGGTGGGTGCCGACCACTTGGTCGGCA

>NZ_CP040438|1|1|161277-161382|CRISPRCasFinder
GTGGGTGCCGACCATTGGTCGGCAC	TTCTACTGTTCTGGTGGGTGCCAAGCTTGCTTGGCACTGGGTCTGGGTCTGCTCTG
GTGGGTGCCGACCACTTGGTCGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_029550824.1\|171114_172410_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|236440
NZ_CP040438.1\|WP_154261879.1\|164019_166065_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP040438.1\|WP_154261882.1\|169376_169997_+\|superoxide-dismutase-family-protein	unknown	unknown	gnl\|CDD\|376292
NZ_CP040438.1\|WP_154261883.1\|170133_171021_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_032128720.1\|151032_151824_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP040438.1\|WP_154261880.1\|166179_167241_+\|PAS-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226370
NZ_CP040438.1\|WP_154261881.1\|167233_168682_+\|nitrogen-regulation-protein-NR(I)	unknown	unknown	gnl\|CDD\|273818
NZ_CP040438.1\|WP_154261878.1\|162310_163477_+\|transglycosylase	unknown	unknown	gnl\|CDD\|225377
NZ_CP040438.1\|WP_014035514.1\|163585_163879_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_032128719.1\|150477_150912_+\|hotdog-fold-thioesterase	unknown	unknown	gnl\|CDD\|182360
NZ_CP040438.1\|WP_100475025.1\|157703_159113_+\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|181884
NZ_CP040438.1\|WP_106466708.1\|168775_169345_+\|superoxide-dismutase-family-protein	unknown	unknown	gnl\|CDD\|376292
NZ_CP040438.1\|WP_032128721.1\|151831_152866_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223506
NZ_CP040438.1\|WP_154261870.1\|152922_154992_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP040438.1\|WP_154261871.1\|155002_155614_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|176643
NZ_CP040438.1\|WP_154261875.1\|159816_161247_+\|ammonium-transporter	unknown	unknown	gnl\|CDD\|182630
NZ_CP040438.1\|WP_154261873.1\|156684_157479_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712
NZ_CP040438.1\|WP_154261874.1\|159456_159795_+\|P-II-family-nitrogen-regulator	unknown	unknown	gnl\|CDD\|223424
NZ_CP040438.1\|WP_154261877.1\|161496_162243_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|225567
NZ_CP040438.1\|WP_154261872.1\|155786_156611_-\|DUF4377-domain-containing-protein	unknown	unknown	gnl\|CDD\|379548

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_029550824.1\|171114_172410_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|236440	PRK09268, PRK09268, acetyl-CoA C-acetyltransferase.	0
NZ_CP040438.1\|WP_154261879.1\|164019_166065_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.7643e-54
NZ_CP040438.1\|WP_154261882.1\|169376_169997_+\|superoxide-dismutase-family-protein	gnl\|CDD\|376292	pfam00080, Sod_Cu, Copper/zinc superoxide dismutase (SODC). superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.	6.84133e-53
NZ_CP040438.1\|WP_032128720.1\|151032_151824_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	2.41593e-38
NZ_CP040438.1\|WP_154261880.1\|166179_167241_+\|PAS-domain-containing-sensor-histidine-kinase	gnl\|CDD\|226370	COG3852, NtrB, Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms].	3.32468e-111
NZ_CP040438.1\|WP_154261881.1\|167233_168682_+\|nitrogen-regulation-protein-NR(I)	gnl\|CDD\|273818	TIGR01818, Nitrogen_assimilation_regulatory_protein, nitrogen regulation protein NR(I). This model represents NtrC, a DNA-binding response regulator that is phosphorylated by NtrB and interacts with sigma-54. NtrC usually controls the expression of glutamine synthase, GlnA, and may be called GlnL, GlnG, etc. [Central intermediary metabolism, Nitrogen metabolism, Regulatory functions, DNA interactions, Signal transduction, Two-component systems].	0
NZ_CP040438.1\|WP_154261878.1\|162310_163477_+\|transglycosylase	gnl\|CDD\|225377	COG2821, MltA, Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane].	4.02549e-114
NZ_CP040438.1\|WP_032128719.1\|150477_150912_+\|hotdog-fold-thioesterase	gnl\|CDD\|182360	PRK10293, PRK10293, 1,4-dihydroxy-2-naphthoyl-CoA hydrolase.	1.85333e-46
NZ_CP040438.1\|WP_100475025.1\|157703_159113_+\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|181884	PRK09469, glnA, glutamate--ammonia ligase.	0
NZ_CP040438.1\|WP_106466708.1\|168775_169345_+\|superoxide-dismutase-family-protein	gnl\|CDD\|376292	pfam00080, Sod_Cu, Copper/zinc superoxide dismutase (SODC). superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.	7.7142e-42
NZ_CP040438.1\|WP_032128721.1\|151831_152866_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|223506	COG0429, COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only].	6.04412e-28
NZ_CP040438.1\|WP_154261870.1\|152922_154992_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	2.26777e-19
NZ_CP040438.1\|WP_154261871.1\|155002_155614_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	3.80391e-50
NZ_CP040438.1\|WP_154261875.1\|159816_161247_+\|ammonium-transporter	gnl\|CDD\|182630	PRK10666, PRK10666, ammonium transporter AmtB.	1.14013e-174
NZ_CP040438.1\|WP_154261873.1\|156684_157479_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	1.10475e-84
NZ_CP040438.1\|WP_154261874.1\|159456_159795_+\|P-II-family-nitrogen-regulator	gnl\|CDD\|223424	COG0347, GlnK, Nitrogen regulatory protein PII [Amino acid transport and metabolism].	2.66367e-55
NZ_CP040438.1\|WP_154261877.1\|161496_162243_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|225567	COG3023, ampD, N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane].	2.16305e-52
NZ_CP040438.1\|WP_154261872.1\|155786_156611_-\|DUF4377-domain-containing-protein	gnl\|CDD\|379548	pfam14302, DUF4377, Domain of unknown function (DUF4377). This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.	1.08537e-26

>NZ_CP040438.1|WP_154261875.1|159816_161247_+|ammonium-transporter
MKMRLLTGWQARFHFVCLLMLLSALAAGAWPGSAHAQAQISPLPSESVAVEPLQDPVAAAAAPAAAEAAATYDHGDVAWMLTSTLLVLLMVVPGLALFYGGLVRSKNVLSVLSQILVVFSLVLLLWVAYGYSAVFSAGNPFFGSFTEFAFLKGFTPESVGNTPIKGLPDYLFVAFQSTFAGITTALIVGAFAERIKFRAVLLFSALWFTLSYIPMAHIVWGGGYLGEMGAIDFAGGTVVHINAGVAGLVAAWFVGKRLGYGQTALKPHNVPFTYIGAMLLWVGWFGFNAGSAAAADTLASLAFLNTVLATAAAVLGWTLVEAISKGKPSALGAASGAVAGLVGITPACGTVGPLGAIVIGFVAGVVCVWGVTGLKRLLKVDDTADVFGVHGVGGIVGAILTGVFSAQSLGGTKADLDIAHQVWVQVVSVGLTVVWSAVVTTLILLVVRSVVGLRVTEEAERTGLDVTSHGESAYEA
>NZ_CP040438.1|WP_154261874.1|159456_159795_+|P-II-family-nitrogen-regulator
MKLISAIIRPFKLDEVREALSDTGVSGITVTEVKGFGRQKGHTELYRGAEYVVDFLPKIKIETVVTDERADAVIEAIQSSAGTGKIGDGKIFVTAVEQVIRIRTGEIGADAL
>NZ_CP040438.1|WP_100475025.1|157703_159113_+|type-I-glutamate--ammonia-ligase
MSVENVEKLIKDNQIEFVDLRFVDMRGVEQHVTFPVSIVEPSLFEEGKMFDGSSIAGWKGIAESDMVLLPDTASAYVDPFYADPTIVISCDILDPATMQPYGRCPRGIAKRAEAYLKSSGIAETAFFGPEPEFFIFDSVRFANEMGHTFFQVDSEEAAWNSGAKYDGANSGYRPGVKGGYFPVPPTDTLHDLRAEMCKTLEQVGIEVEVQHHEVATAGQCEIGTKFSTLVQKADELLRMKYVIKNVAHRNGKTVTFMPKPIVGDNGSGMHVHQSLSKGGTNLFSGDGYGGLSQLALWYIGGIFKHAKAINAFANSGTNSYKRLVPGFEAPVMLAYSARNRSASCRIPWVSNPKARRIEMRFPDPIQSGYLTFTALMMAGLDGIKNQIDPGAPSDKDLYDLPPEEEKLIPQVCSSLDQALEALDKDREFLKAGGVMSDDFIDGYIALKMQEVTKFRAATHPLEYQLYYAS
>NZ_CP040438.1|WP_154261873.1|156684_157479_-|undecaprenyl-diphosphate-phosphatase
MSDLLSALLLGILEGLTEFLPISSTGHLLIAQHWLGARSDFFNIVIQAGAIVAVVLVFRQRLLQLATGFGQRENREYVFKLGAAFLVTAVVGLVVRKAGWSLPETVSPVAWALIIGGVWMLLVEAYTARLPDRDQVTWTVAIGVGLAQVVAGVFPGTSRSASAIFLAMLLGLSRRAAAAEFVFLVGIPTMFAASAYTFLELVKAGQLRSENWTEVGVAFLAAAVTGFVVVKWLMGYIKSHRFTAFALYRIALGAALLLWLPSGS
>NZ_CP040438.1|WP_154261872.1|155786_156611_-|DUF4377-domain-containing-protein
MNRKLTLLLPLALMAACSQTPAPAGNGGDDVAPAAAKAADQQTLAHLDAQRLQSQHWLLQQATAADGKRIDALFAREDKPVTLDFADGRLSVSNACNHMGGGYTLADGKLTVSAMASTMMACTDKALMALDEAVSSRLQGELKAEQDADGKLTLTNAKGDVLVFNPEPTAETRYGGAGETVFLEVAAKTEKCSHPLIPDYQCLQVREVKFDDKGLKQGEPGKFENFYGNIEGYTHEDGVRNVVRVKRYEVKNPPADAPSQAYVLDMVVESAIEK
>NZ_CP040438.1|WP_154261871.1|155002_155614_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MQLSSHSLTNGAPIDREFAAGDATGFAPDRNPHLAWNGAPEGTRSFLLVCVDPDVPTVAETVGRSDMTVPRDQPRCDFVHWVMADVPASVQEIAAGSCSDGFVVKGKTAPAGPAGSRQGLNDFTGWFAGNPDMAGDYLGYDGPYPPFNDERVHRYFFRVFALDVASLELPARFTAADAYRAMHGHVLAEAALHGTYTLNPALG
>NZ_CP040438.1|WP_154261870.1|152922_154992_+|tetratricopeptide-repeat-protein
MQDQIIQALRQNQADQAVQLAQAWTRDEPGQAEAHRWLALALQQQGKAEDAMEALQQALQLAPDDAQLHLQHAGLLLALRQYQGADEALARTTGLDPNSFAAYLMQAHLAIGRNDFDEAQRLSTLASRVEPDHPELLTIDGMIALRRDDPDRALTLLSAANQAQPNDTRVLYALGFAYLGKDMLAFAEQAFRRVLELNPAISSLHGLVVQLALRQGNLEAAAEAMQIALQQEGMDTPSMRRLAGELSLRGGQPLQALDHLLPLLESIPDDRQVLQLLLMSWQRLSREDEARARLDAALEQHPQLHDLWLARLAVEEVGSPTAAATVERWMDAMPGHLPALEARLRLHDMVGEHEQAEAIAERIVSLEPGRVSGETRLVEGLLQRDPVAAIARVQALIDRAPDGHRADLRTWLGEIQDRAGQPEQALQTWMALQADQAPQRLPLPPQAKAPPSWPEKGEIDSDASSAPIFLWGAPGSGVERVATGLAAASPVLRSDRYTSNPPDDAFQNYHTLQDLASGVLTPERLVQRWREQLPARGLQGDAVIDWLLWWDNALLWALRPQLPQGRLVLVLRDPRDMLLDWVAYGAAAPLAMTSLAEASEWLARALAQVATLHEEELYPHVLLRIDQIGNDPHAMAELLGRLFERQMPPAAQLGAPRFPPGHWRNYRDVMSAAFAKLTPIAVRLGYPEE
>NZ_CP040438.1|WP_032128721.1|151831_152866_+|alpha/beta-fold-hydrolase
MALVPPPVLDAGTPTLHATDYQPPRWLRNPHLQSMLSSSRMRLQRGLLLLAATGAVSEELILDGGDGVRLQGWHSHVEGREPKGMALLLHGWEGSAESSYMRMAAARMIEQGFDVVRLNFRDHGNTHHLNPGIFHSNLIDEVVHAAGDIAQRWPQLPLVAAGYSLGGNFVLRLALRAPAAGVPLLRVASVCPVLDPGLTMESIENGPAMYDWYFRRKWAGSLRRKRDLFPELSDCDDRVLKLDIRALTAWLVERHTTFGSLQAYFDGYSIAGDRLSTLQVPADILMAQDDPVIPYATFSDWQLPRQAHLETACWGGHCGFLENWRGDGFSERWVAQRLQRVLAG
>NZ_CP040438.1|WP_032128720.1|151032_151824_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MTSPTPAPRGGVARVCRYLYRVPLLLVHITVFLPLILIGMLPPWGELRVGEDTFGAKVVNWWQGGLMWIFGFRLSRVGQPLPGAVLFVANHVSWVDISILHSQRMMGFVAKREIASWPLVGWLAARGQTIFHQRGNTESLGGVMQVMADRLRAGKAVGVFPEGRTRGGHEVGPFHARIFQAAVETGVPVQPVALVYGFKGDAQTIVAFGPGESFAANFLRLLGEPARHTEVHFLEPIGTQDLEGRRRIAETSRARIVAAMSTG
>NZ_CP040438.1|WP_032128719.1|150477_150912_+|hotdog-fold-thioesterase
MTQVFREAVSIEQLNALSRNTAIESLGIVFSAAGEDWLQATMPVDERTRQPYGILHGGASVVLAETLGSSAGNLCVDTGKQICVGLEINANHVRAVRSGTVTGTARALHVGRSTQLWEIRIEDEQGRLVCISRLTLAVVAAGHG
>NZ_CP040438.1|WP_154261877.1|161496_162243_+|N-acetylmuramoyl-L-alanine-amidase
MHSTRTALMLSACLLLAACASAPQETRNPLATWVPSPNQNARTPVIIVIHHTEQKSVQQSLRTLRTANSGGPVSAHYLIGADGHRYQLVADERRAWHAGAGRWGTITDLNSASIGIELDNDGRSPFSAAQIESLIVLLRDLTTRLNIPSRQVIGHADLAPTRKQDPSRFFPWQQLAEAGFGVWPRASDGPAPEGFDAWTALARFGYPLDNREATVAAFHRRFRGQDDLPKTLDAEDARILHSLLLQTP
>NZ_CP040438.1|WP_154261878.1|162310_163477_+|transglycosylase
MIDSAIFFKRKHCILLAAAVLAGCATTTPRTGSEAPTPTSPPAATYAKVDWKALPAVSDADLQAGFVAWRSSCTRLKNDAVWAKPCATAAAVSDKDPAAIRQFLQRDLDVYALRAGGHQADGLITGYYEPIYPGSLTRTAAATVPVYGTPDDLVVVQLDSIYPELKGKRLRGRVEGKVLKPYDDAGTIAAKGAKAPVLAWLTDPMDLQLLQIQGSGRVRLGDGTQVRLAYAEQNGHPYRAIGRWLVDQGQLKKEDVTMDAIRAWARANPARVPELLRSNPSYVFFVRNPDSPEGPRGSLNVPLTAGYSVAVDRTVVPLGSLLWLSTTRPDGSPVVRPVAAQDTGGAIAGEVRADLYWGSGDAAGKLAGDMKQKGNIWMLWPKGVALPN
>NZ_CP040438.1|WP_014035514.1|163585_163879_+|hypothetical-protein
MKNIKNNNAKKYYKHWAESGLGKGNVLMEARGEKIVRQVEIYGTKMVWADEHAHSDDRFLLADQPVSFLDFDEDDEISAREFESAWKKAREATGYPV
>NZ_CP040438.1|WP_154261879.1|164019_166065_+|TonB-dependent-receptor
MKTSTLVATLAAAPFAPEALAQSADAALTLGKVQVQQHGEGQLSAHQVLTSVDVLGADQIENRNVSHSWELLGQMPGIQLTETRQGAESGKVSFRAFNGEGYLNAIKTLIDGIPSNVNSGNQRFIDMLFPLDISYIEVVRGTNDPRYGLHNIGGNVNFGTRQGGSYTDARLAYGSYNTRDAQLAVGREANGFAQNYFVGTQASDGYRDHDTSKKYSLGGKWFYGSLDDGLRVGLSARAYHHEADEPGFMTADELREHRRGSDLRNGNDGDDRDMRQVAAHLDLKLSDALTFGTRLYYNRYEDDRRVTFSDLPSGNLPRQRRVWDERQAGLLSTLTWQASPVLTVEGGLNYEQQDNGYLRERYAYAEPTDFSQPPARVQNNDRHSFDNWGAYVQAIYQPAEAWKIVPAYRVDRFSGRTHLMNGVSGRLQEYGSIGQPKLSVIHSLGQATHVYANWGRTFQVLTGSTAPAYLTPGQAPMQPSTNTGMELGLKFEPFAGSQARLAVWQQDAENEVSNMPATGTTVTLGRTRRRGVDAQVSLQLGDDWTVWASHAYQEAKITRDDRDASVSLQGREVAATPRHISNLGVDYRASDALRLSLQARAQGDYYLEERNVASKFGGFAVLDLSAAYQINPRWSVDLQLKNVTGREYAYAWYDSFFWDSARPMFSPAPGRSVFVGLNMKL
>NZ_CP040438.1|WP_154261880.1|166179_167241_+|PAS-domain-containing-sensor-histidine-kinase
MSDPAPPPSLDALGTPLAWAGADGCIAGCNPAFARWLGVSARRLLGRPLAALEVQGEALAHFLARDERDSLRLNRLALAVPGEAPRFAEGWMSRRDDGGWLLEAHPVDEFPGLDPTQALPSALSAALKGLAHELRNPLAGLKGAAQLLARRAAQRDASERELIELIGSEIERLNGLLDQLLSPAPAAPHAELNIHAALERVLRLAENEAGWAVRLQRDYDPSIPEFHGDADRLTQAVWNLVRNAIQAGAGNITLRTRVEHGVRIAEQLHTLALRLEIADDGRGVPEELAEHLFLPLVSGRAEGTGLGLALAQQVAREHRGTLTYRSRPGHTVFTLLLPIVSGAAPAEEVPRDV
>NZ_CP040438.1|WP_154261881.1|167233_168682_+|nitrogen-regulation-protein-NR(I)
MSESFSSPQRIWVVDDDRAVRFVLCTALREAGYQVVDFDSAAPALQALSEGPPPALLFTDVRMPGDDGLVLLDKLKAALPQLPVVVMSAYTDVASTAGAFRGGAHEFLSKPFDLDDAVALAQRVLPAVAPALAAPTPAAEAHGDQPPQLVGDTPPMRALFRAIGRLAQAPLAVLITGETGTGKELVANALHRESPRAQGPFVALNTAAIPSELLESELFGHEAGAFTGAQRRHIGRFEQANGGTLFLDEIGDMPLPLQTRLLRVLAQGEFFRVGGRELIRVDVRVIAATHQDLEGLVAQGKFRADLLHRLDVVRLQLPPLRERREDIAQLASTFLAAAARKLDTPPKRLTAAALQALREHDWPGNVRELENVCWRMAALAAADTIGVADVDTALNRTRGRRSSTTSADPGQWEALLAEWARRQLAEGVEGLHAQVRERVDHALLEAALQITHGRRAEAAARLGLGRNTLTRKLGAGRRRGGH
>NZ_CP040438.1|WP_106466708.1|168775_169345_+|superoxide-dismutase-family-protein
MRLSFAILPLSAAVLLSACGSAPKKAEPTPPPPVAVSAAKQAEANLAPASASIVSGRIALMVEPGGIHITGLIGGLQPMQQAGFHIHERGDCSAVDASSAGNHFNPGGAAHGRAGTGKHHLGDMDNLRADAQGRANVDIHLKGVTLGGGAATDIAGRALVVHANADDYRSQPAGNAGVRIACGVIRVVR
>NZ_CP040438.1|WP_154261882.1|169376_169997_+|superoxide-dismutase-family-protein
MRLIHTSLFAAIAALGLAACNQQPAAPQAETPPAAPADGATTEPAAAPAAAPAADASATAELAPTQGNETKGSVTFKVVDGKVHVTGQISGLKPGSEHGFHIHEKGDCSAPDGMSAGGHFNPGKQDHGSVSADPHHGGDMPNIKADDKGVATIDGPVSSNVNIGKGDDFDIIGRGLIVHADADDYKTQPTGNAGARLACAVIQKAP
>NZ_CP040438.1|WP_154261883.1|170133_171021_-|hypothetical-protein
MSKPDPAMNALGVLALELAGGEIPRQAVLSAEQAGELADRVGRDLSKLVPQVAELDLVFAAAHFDPAEVLRPGWPIHRRLEELQMRAPGRNQGPRLLAFGTDANGDVPLPFQADASLVGGGLRVVPFLLTGSDVATTNAVAEALEETLLANGMAHADTALMAQNTFGARIEHARYFTVNDLAAMMSMQYDNQGLAALWPLIETAIMAPGEDEWLNAAPEPLLRYTHGEARMALFDPAGWCAHYNHGKNDCDRLKGIYEQFLMRQRQMAAVLEAHGVPVLFVHCEAGQDARELLAR
>NZ_CP040438.1|WP_029550824.1|171114_172410_+|acetyl-CoA-C-acetyltransferase
MPGISMPNARPVAILGGVRIPFCRQNTAYSDVGNLGMSVRTLGALVERFGLHGQQLGEVAMGAVIKHSSDWNLGREATLSSGLSPLTPGITLQRACGTSLDSIITVANKIALGQIESGIGGGSDTTSDVPIVYGKKLRARLLAANRAKSTGDKIRALTAGFKFSELKPEFPGVAEPRTGKSMGDHCEDMAKEWNISRDSQDEWAVSSHKKLAAAYERGFFNDLIAPFRGVERDNILRPDTSLEKLATLKPAFDKVSGRGTLTAANSTPLTDGAAAVLLASEEWARAHGHEPQAYLRDAHVSAVDFVHGEGLLMAPTVAVPEMLKRNGLTLQDFDIYEIHEAFAAQVLCTLRAWESEDYCRNRLGLDAPMGRIDPDKINLLGSSLATGHPFAATGARVIATAAKQLAERGGGRALVSICTAGGMGVVAIVER

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Crispr_ID: NZ_CP040438_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_2

560654-560763

Orphan

Consensus_repeat	Method
GGTAGGTGCCAACCTTGGTTGGCACGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040438_2

>merge|NZ_CP040438|2|560654-560763|CRISPRCasFinder
GGTAGGTGCCAACCTTGGTTGGCACGCGTTGCGCGATAGAGCTTCATCCACGCATGGCGTGGATCTACTGACACCATGATTCTGGTAGCTGCCAACCTTGGTTGGCACGC

>NZ_CP040438|2|2|560654-560763|CRISPRCasFinder
GGTAGGTGCCAACCTTGGTTGGCACGC	GTTGCGCGATAGAGCTTCATCCACGCATGGCGTGGATCTACTGACACCATGATTCT
GGTAGCTGCCAACCTTGGTTGGCACGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_049456360.1\|573689_573938_-\|DUF3297-family-protein	unknown	unknown	gnl\|CDD\|371696
NZ_CP040438.1\|WP_154262162.1\|564070_566182_-\|M13-family-peptidase	unknown	unknown	gnl\|CDD\|341056
NZ_CP040438.1\|WP_154262148.1\|549431_550628_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_049424804.1\|570610_571021_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP040438.1\|WP_154262165.1\|571052_571841_+\|dioxygenase	unknown	unknown	gnl\|CDD\|153375
NZ_CP040438.1\|WP_154262147.1\|548061_549324_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|227277
NZ_CP040438.1\|WP_154262151.1\|552513_554157_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367655
NZ_CP040438.1\|WP_106466942.1\|571958_573608_+\|Na+/H+-antiporter	unknown	unknown	gnl\|CDD\|129911
NZ_CP040438.1\|WP_154262153.1\|556382_557642_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NZ_CP040438.1\|WP_154262154.1\|557631_558402_+\|response-regulator	unknown	unknown	gnl\|CDD\|225818
NZ_CP040438.1\|WP_154262155.1\|558420_558765_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154262164.1\|569632_570514_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP040438.1\|WP_154262149.1\|551819_552497_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154262157.1\|560852_561440_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182632
NZ_CP040438.1\|WP_154262160.1\|562784_563957_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP040438.1\|WP_154262152.1\|554557_556207_+\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349910
NZ_CP040438.1\|WP_154264894.1\|566358_569421_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP040438.1\|WP_019337987.1\|550618_551719_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_032128761.1\|558804_559419_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154262159.1\|561573_562788_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_049456360.1\|573689_573938_-\|DUF3297-family-protein	gnl\|CDD\|371696	pfam11730, DUF3297, Protein of unknown function (DUF3297). This family is expressed in Proteobacteria and Actinobacteria. The function is not known.	3.5682e-44
NZ_CP040438.1\|WP_154262162.1\|564070_566182_-\|M13-family-peptidase	gnl\|CDD\|341056	cd08662, M13, Peptidase family M13 includes neprilysin and endothelin-converting enzyme I. The M13 family of metallopeptidases includes neprilysin (neutral endopeptidase, NEP, enkephalinase, CD10, CALLA, EC 3.4.24.11), endothelin-converting enzyme I (ECE-1, EC 3.4.24.71), erythrocyte surface antigen KELL (ECE-3), phosphate-regulating gene on the X chromosome (PHEX), soluble secreted endopeptidase (SEP), and damage-induced neuronal endopeptidase (DINE)/X-converting enzyme (XCE). Proteins in this family fulfill a broad range of physiological roles due to the greater variation in the active site's S2' subsite allowing substrate specificity. NEP is expressed in a variety of tissues including kidney and brain, and is involved in many physiological and pathological processes, including blood pressure and inflammatory response. It degrades a wide array of substrates such as substance P, enkephalins, cholecystokinin, neurotensin and somatostatin. It is an important enzyme in the regulation of amyloid-beta (Abeta) protein that forms amyloid plaques that are associated with Alzeimers disease (AD). ECE-1 catalyzes the final rate-limiting step in the biosynthesis of endothelins via post-translational conversion of the biologically inactive big endothelins. Like NEP, it also hydrolyzes bradykinin, substance P, neurotensin, and Abeta. Endothelin-1 overproduction has been implicated in various diseases including stroke, asthma, hypertension, and cardiac and renal failure. Kell is a homolog of NEP and constitutes a major antigen on human erythrocytes; it preferentially cleaves big endothelin-3 to produce bioactive endothelin-3, but is also known to cleave substance P and neurokinin A. PHEX forms a complex interaction with fibroblast growth factor 23 (FGF23) and matrix extracellular phosphoglycoprotein, causing bone mineralization. A loss-of-function mutation in PHEX disrupts this interaction leading to hypophosphatemic rickets; X-linked hypophosphatemic (XLH) rickets is the most common form of metabolic rickets. ECEL1 is a brain metalloprotease which plays a critical role in the nervous regulation of the respiratory system, while DINE is abundantly expressed in the hypothalamus and its expression responds to nerve injury. A majority of these M13 proteases are prime therapeutic targets for selective inhibition.	0
NZ_CP040438.1\|WP_049424804.1\|570610_571021_+\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	2.25199e-09
NZ_CP040438.1\|WP_154262165.1\|571052_571841_+\|dioxygenase	gnl\|CDD\|153375	cd07363, 45_DOPA_Dioxygenase, The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine. This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.	5.60478e-123
NZ_CP040438.1\|WP_154262147.1\|548061_549324_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|227277	COG4941, COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription].	3.07468e-131
NZ_CP040438.1\|WP_154262151.1\|552513_554157_+\|hypothetical-protein	gnl\|CDD\|367655	pfam03783, CsgG, Curli production assembly/transport component CsgG. CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB.	6.76244e-07
NZ_CP040438.1\|WP_154262153.1\|556382_557642_+\|sensor-histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	1.08822e-43
NZ_CP040438.1\|WP_154262154.1\|557631_558402_+\|response-regulator	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	2.39555e-51
NZ_CP040438.1\|WP_154262164.1\|569632_570514_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.65276e-92
NZ_CP040438.1\|WP_154262157.1\|560852_561440_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|182632	PRK10668, PRK10668, DNA-binding transcriptional repressor AcrR; Provisional.	1.94306e-14
NZ_CP040438.1\|WP_154262160.1\|562784_563957_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	6.11095e-76
NZ_CP040438.1\|WP_154262152.1\|554557_556207_+\|M28-family-peptidase	gnl\|CDD\|349910	cd05660, M28_like_PA, M28 Zn-peptidase containing a protease-associated (PA) domain insert. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins containing a protease-associated (PA) domain insert which may participate in substrate binding and/or promote conformational changes, influencing the stability and accessibility of the site to substrate.	5.05047e-105
NZ_CP040438.1\|WP_154264894.1\|566358_569421_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.10835e-94
NZ_CP040438.1\|WP_106466942.1\|571958_573608_+\|Na+/H+-antiporter	gnl\|CDD\|129911	TIGR00831, Putative_Na+/H+_exchanger_Rv2287/MT2345/Mb2309., Na+/H+ antiporter, bacterial form. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds].	4.2532e-102
NZ_CP040438.1\|WP_154262159.1\|561573_562788_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.3922e-20

>NZ_CP040438.1|WP_032128761.1|558804_559419_-|hypothetical-protein
MIALFKGLGLLLRDNELYSSPFEKQVAHWRSLSEQQIRDEVAVLAQAKCQWLIASIVGWQAASLLILGLITNYLWRDDYHITFTRVVVVFGSWISILFVIWFMANMFDRTAGFERWMKAFNSRARISSKADSVENVAEALDLAEHYPEVLDYKQAVTAKRELRHEDIRIMTEIGRMKQHSELVGRLNHVGENEHHHDLTLQPAY
>NZ_CP040438.1|WP_154262155.1|558420_558765_+|hypothetical-protein
MRVFLFACVAALSLAGCEKSSETSITRTNANGVDTLYSKRTVVDGEARFQCIASSSGHCHYVVLDPACSSEAACATPPLRRFAVAVGKTEAMRDLPRGFHQCVSQDPIEQCHRE
>NZ_CP040438.1|WP_154262154.1|557631_558402_+|response-regulator
MPLEALIAEDEELLRQSLVEQLGRLWPELKLVAECEDGASALEQLAEKQPDIAFLDIRMPGISGIEVARSLSELSPRTQVVFVTAYDQYAIDAFEQGAMDYLLKPVSDERLLATRERILSRLPSTRQDDAVLERLLQRLGPSQAAAERPPLAWITASNGRETQLIMLEDVAYFRADNKYTTVMTAAGESLLRTPLRELLEVLDPQHFRQVHRSTIVNMKAVAAVSRDDTGRGVLRLRGRTETLVVSQPFMSLFRGM
>NZ_CP040438.1|WP_154262153.1|556382_557642_+|sensor-histidine-kinase
MIASLSLILRHLLAWAAALFVAGMVWSGIFSGMNDGPGWVFGLLVMFLMISALGSAVTHVRRVWLVAGRLDGATLSGRQRRQIELPMDAGHAFAVVEAAVGELPRVEEVESSAGSLQVRAYVRRVDLWNGRQPSRWNLPARLAIKRNSVLATVTPGQGTSTVTLLFEPDAGWWADLLALDEGSNYENAEAVTRAISRRVADQRRDEQAAAEQTQVEKELSVARLNLLHAQVEPHFLYNTLANAQVLTRTDPARADQMLGHLIQYLRSSLPQVDESLSTLGVELERTRAYLEILRIRMGARLGVEVQVPNELHGVQLPAMALQTLVENAIKHGLEPKPGGGTIWILARGFDDHVTVTVADDGLGFGQGTSGTGIGLKNLRERLRLTCGEQAGVAIVANFPCGVAATMTLPQSSKERSHAA
>NZ_CP040438.1|WP_154262152.1|554557_556207_+|M28-family-peptidase
MKRVVLGVLALSVSSALMAATPKFDGARISADVKELASDAYEGRSPATAGEEKTIAFLSKQFADAGLQPGGDLKDGKRLWTQAVPLRKGDIVGAPQLALHQGGKTVALEQGKQIAVRAAMNGASNVDISKAPLVFLGYGVKAAERNWDDFKGVDLKDKIAVVLINDPDFETGQGDFDGKGMTYYGRWTYKYEEGARQGALGVLIVHETAPASYGWATVAGSNTNTMFDVVRDNPADSHPLLEGWIQRDLAVELFRSAGQDFEALKKKAQQRDFTPVPLTGASLDAKYAVKTEVITSHNVAARLEGSSHPDETVIYSAHWDHIGVGEPDARGDRIFNGALDNASGTASLIELARGFAKQKRPQRSVLFLAVTAEEKGLLGSEYYATHPLYPLEKTVAVINMDGMAPFGPSRDFGIYGAARFELLDQLKDVAKGWDIRYTPDPKPEAGLFFRSDHFPFAKRGVPALSWSAGQDWVDGGVAAGKKASEDYTAKRYHQQGDEWQPDWVFAGAARDLEVLYTLGNQLANARSWPNWSKDESFRAVRDASADQRK
>NZ_CP040438.1|WP_154262151.1|552513_554157_+|hypothetical-protein
MRMTYRLIGLGLAAALLAACGKQDTPAAAPAKDKATSALASNAPVEAAPLRGTPDFGSTTQVAREADGIGSTPELAVLAALQSAVAQVNGVRVASQMQSLRAGLHVDVDDEHVGDIRADAFTQQMIAGSQGAVLGYEILSQDEVRQLDEETIARVRASDEGWSFKGSASASASGEASAKSGSASASVRESYDEKINVDAKRGASSFDSDVTHRSMRSYWKVRVRAQIAQYRAPDEQGKPKIVVALPRTKAGSYAVGDGRVDADEVADAIRARLSDTLTQTQRFIVLDREFGDELQAEIDHINSGNVRLQDTARVGQQLATDLILIPTIERFEYPRSVRNLRMSDRQVTSYSGGGRITLRLVNATTGQVVMSDSFDHQLASTGPSTLPRVVNGRNMAAAMMESLSGQIGTSIVTTLFPVSVVSVDGDQVVLSQGGDTVQAGQRWQAVRLGEELKDPQTGRSLGRSEHPCCTIRIDRVAAQTSYGTIEDGVDAMRGGFRPGQIELRQKLGSKPAAAASATASAAPAAAARPAAKPKPKPAAAPAEDPNW
>NZ_CP040438.1|WP_154262149.1|551819_552497_+|hypothetical-protein
MIRNTALVVAIAAATLSMPAHAGLGKLKDLAGAATGTSSSSASSAAAPDEAAQEALVRRFVSSQSHSLQAQTSFARAFGLAEQVQLLEAERQALSSGSVSVDAMKKSVSVSEAAQAAINERQAAQPELNAESKQHYAEGLVSLLSSAAEAQKLGGEASNFTAGMKNLGATQLATVGRKLAAGAWVAKESPGFIQGLYGSTKSAVTFARKSKVKVPSNADSMLDTL
>NZ_CP040438.1|WP_019337987.1|550618_551719_+|hypothetical-protein
MSLMRTILLILIALVVASPVAAQTASSRGTGSASYGLRLSADTRAQALNKAKVNALEAYIAETGAAKLRLFEARRAEFIGEIDRYVLSAVQLSDTEDKKAKTYTVTVRAEINTTLLQTKLDAGSAVAGATAAQRSLLTFLFMARSQDTVQSFQDKEYRRVDASSSYSENTREGDSFRGNSVSTNGSINQNGSMSVTSGGSTTQRSDNISWKVANAAEVNTAMTGAFSAAGYEVVEAEYVEGESRGLLSIERIRKDFSTGNDLAPATLRDTANGIRAANIPYIAVGTLDVGMRDRDPASGNTRVFVTVTGKVLDVTGRFPRTVSSVGPVQFSGTGPNETVARTNALQLAAEKAAQQMINELNVKAVR
>NZ_CP040438.1|WP_154262148.1|549431_550628_+|hypothetical-protein
MYSRTKSASRAFARLLACALCLAVWPMAVQAADKSQQAYWAGFAYTADAAAVQATTPHAHAVLEQRGLIPLNQALAQSLKRRAPAHLQLIDQPVAMLDGTTSATVLAAALDRELVSVEPIGDQYKVLVEVALQALFFDFRERQVIASYPLTLQRIDVQDYRPDNDDIDAIVADLLYGSADTSLSQVLAASLAHARLPDAAMRRLQVGGVTLSDAVRAKLPDPKWEAPLRATLAHELSKTLSSNTGVGLLPPASGQAIGGAMAARFADGKVYQLKIPEPDYVINLQVDALKNGVIEETPAMKTMLFGAFFTAKVTEPFSGKVYFEQPLRKGATKVVPVTQWQVDQWSASYETLLAGFDAFAGAAAKRADSRGWLDEQKPGGRPLQQQTQALQELIKSCR
>NZ_CP040438.1|WP_154262147.1|548061_549324_+|sigma-70-family-RNA-polymerase-sigma-factor
MLEPALTQRLETLWRMESPVLIARLARLLGGDVGRAEELAQDTWLAALERWPEQGIPDNPGAWLMTTARNRAIDVLRQHQRVAQQHAQWGDELHPAALPAPDDSQALEDDLGDDLLRLMFVACHPVLPADARVALTLRLLGGLTTTEIARGFLQPEPTIAQRIVRAKRTLAQKQVPYEVPRADAMPERLGSVLEAIYLVFNEGYAASAGDDWMRPALCEEALRLARILAHRLPVPPVLGLLALMELQASRAAARTDAQGVPVLLDQQNRARWDWLQIERGQQVLARALAAGGADDPYVLQARIAACHAAARRPEDTDWPRIAALYTQLLQVQPSPVVALNRVVAILRSDGAFAAWAQLQPLLVDTRLREYAPLQVVYGELLQKLGREQDARHAFAEAARLSQNQAERGLLRQRAGLPPAE
>NZ_CP040438.1|WP_154262157.1|560852_561440_-|TetR-family-transcriptional-regulator
MVRRTRAEMEETRATLLATARRVFSEHGYAATSMDDLTAQAGLTRGALYHHFGDKKGLLAAVVTQLDAETDLRLQAISDGADDAWDGFVQRCRAYLEMALEPEIQRIVLRDARAVLGGASPESQRHCVHSMQHLIEHLVAQGVVAPVDAQALASLIYGSLAEAAFWIAEGEDGDARLQQATAALEMLLRGLKSAG
>NZ_CP040438.1|WP_154262159.1|561573_562788_+|MFS-transporter
MATPYRDLFAAPGTAGLALAGLLARLPLPMTGIGIITLLSQLRGSYALAGAVSATFVLTYALLSPQVSRWVDRRGQGRVLPWATAASAAGLLLLLACTLLAAPDWALFIAAMLAGCMPSVSAMVRARWTAIHRGRPQLQTAYSLETVFDEVTFIAGPPLSVGLSVAVWPQAGVLAAALLLVLGVTALVLQRGTEPPLQRCEGATPSRSPLRQAEIRLLALLMLAMGVIVGTVDITSVAFAEQRGQPLAASWVLSAYALGSCAAGLLFGALKLQIRLPRLLLTGAAATALATLPLLWVGSLPALAVAVLLAGVFFAPTMIVAMSLVEQYVPESRLTEGMAWLLAGLNIGVALGAALSGQSVDAGGVRSGFVVALVAGGGVLLFAVLAQRALRPSASTTSPEGIVP
>NZ_CP040438.1|WP_154262160.1|562784_563957_+|MFS-transporter
MSASSPAHAAPVPRHPWWAVSAVGLATFSVVTTEMLPVGLLTPIAEDLGASTGTAGLMISLPALLAAVFAPLVVIAAGGIDRRRILCALLALLLVANLASALAPGIGWLLAARVLVGFCMGGIWAIAGGLAARLVPADRIGLATSIIFGGVAAASVLGVPLGALIGDALGWRSAFAAMALLSAAAMLLHLRVVPALPVSTSVRPRQFVQQLGQRDLRRGLWLTVLLVSGHFIAFTYVRPLLTSISGVDASWIGALLFGYGLAGIAGNFIAGPLAARHPRGTVLAIASGLLLTPLLLLWLGGTPSGGIAVLLLWGLAYGGVSVGLMSWMMKAVPQAVEIATALYVGVFNIGIALGAWGGVRLLDGVGPYATLWAAAVLAASALLMVATTRR
>NZ_CP040438.1|WP_154262162.1|564070_566182_-|M13-family-peptidase
MSKLRRPTLALAIVASLSLAACDRPAEPAAGTAAPADAAPAAAKPMLGSFGFDASGMDRSINAGDDFFGFANGTWVKNTEIPADRSRFGSFNVIAEKTLADTRAILEGAAGNTQASGDDKLIGDYYAAYMDEAGIEQHGIAPVQPQLKAIDAIADKAGLARALGGDVRADVDLLNATNFYTDRLFGLWVSVDLLQPDRNAPYLVQGGLGMPDRDFYLGGGRMAELRKQYQAYIAQMLQLAGVADPAGKAQRILALETKIAQAHATQEETNDVTKGANPWTQADFNAKAPGMDWNAFLDAAALGQQQDFIVWQPKAVAGLSKLVATEPLDVWKDYLAFHTLDRAAAYLPKKFADARFAFHGTTLSGTPQQSERWKRAVDDANHAIGEAIGKRYVEKHFDAKTKERADEMAKNIIAAFAKRIDALAWMSPQTKASAKAKVAGLTVGMGYPEKWRDYSGLEIRRDDALGNAQRAELFEYQRNIAKLGKPVDHTEWAMLPQTINAMNVPLENRLVFPAAILQPPFFDGAADDAVNYGAIGAVIGHEISHGFDNAGALFDETGKLHNWWTAEDLKQFNAAGDALAAQFSSYEPFPGVHVNGKLTLGENIADVAGLGTAYDAYQLSLQGKPGQTLEGFTPDQRFFLGFAQAWRSKSREQALRNSLLTDVHAPGQFRALTVRNIDAWYPAFEVKEGQKLYLAPDKRVKVW
>NZ_CP040438.1|WP_154264894.1|566358_569421_+|EAL-domain-containing-protein
MRGRVRRQEWRPPAVEVGDVEDSFAHEASRQHKEAQPMPALKRALARPLRAITWGGVLLGVLLVAGLATMLINDHQRRLEAAQRQSRALAVGSERLLALELRNLERAMSGIATDAAELFRSVPVQAPALLDASIGGVLRRHAELHSIVVLDSHGRPLTAGKGDLQLPLWTDPQRRGQGSALYIGPPQRASDGGWVVPLALPMAGDRWLLARLRCGELQRIVGGLDVGPNGLVSISDAEGYMLARVPDPHGTVGRRYDLPRRDLLGKQAVVELGSLPGVVDGVPRIITISTLERSPLAVQVGLADEDVLAPWWPYLQASVAIMLAYIAVLLVLLYAVRRSTRSQQAMAEELKTGHAELRLAHQVGRVCTWYVDEDAALLRWSPLAREIFGVQTDALPVADFFARVHRDDAARLQQAFDQAFAGGAVLDQVFRLVLPGGAVRWVGARGQRVEVADSERRMIGALTDLSERYQAREQMSEVERRFRLLFDRNPAPFWVFDPDTLRFIEVNDAAVRQYGYSREEFLAMSILDIRPREGWDEVKGAIAKARAGELQDATVRLHRRKDGSVFEVRAHLSKLDFDGQPACLVLAEDVSERLAYERDLAYQARHNPATGLLNVRALTGQLDEQQEGYTIAFVQLRGLQLVADTLGREIGDAVLQSMATRLGGLGARCGTLAFQPAEDFVFAIGAEHDTQRVLDDLLQIVSAPMRGKDSLHQFEPRIGVAVHVPGDGHSAEQVIGMAAQAAHAARAEGNVVVWFDAAVTTRLADRLRLAGRIHAAIDNEFELYFQPIRHASDGSPAALEALLRWPQADGSFIPPNEFIQLCEDTGLILALGRWVIRAAAKAQRRLVEAGWGELPIAVNVSAVQFFNSDLVAEFTRAQQEFGLARGALHVELTESSLMRKPAQAMQTMQRLHEQGISVSLDDFGTGYSSMSYLQHLPLDILKIDRSFVADVETNPRNASICRALLSLGHSMGLTIIAEGVETPGQLDWLAAHGCDQVQGYLLGRPAPLEQIIDALDEVAA
>NZ_CP040438.1|WP_154262164.1|569632_570514_-|LysR-family-transcriptional-regulator
MDTLEAMRVFVAVVERNGFSAAAQALDMSTAGVTRQVAALEKRLSTRLLHRTTRRVSPTSAGAAYYAQCVRLLAEFDALEASIGAQALEPSGTLRINAPVSWGIARLGPLLASYRERFPQVELDLALSDRLVDMVEEGYDVAIRITREPGPTLIARRLGESRVSLCAAPAYLAARGTPQTPQELQAHACLSYSYWAAGDHWPLQGPGGEVKVAVSSLLHANNGDVLREAAIAGMGVILQPDFLLEDALADGRLVRILPEWEAAPIGIFAVYTSRSHLAPKVRSFIDHLVEAGV
>NZ_CP040438.1|WP_049424804.1|570610_571021_+|DoxX-family-protein
MHTTTAPVSPLAPYGATLLRLALGVLFLVHALIKLLVFTPAGTAAFFESLGLPGVLGYLTIGVELVITVALLLGIYARWVGLVGVPLLLGTIVTVHGANGFGFANAGGGWEYPAFWALALVVLFLVGDGKWTLRSR
>NZ_CP040438.1|WP_154262165.1|571052_571841_+|dioxygenase
MSRLPSLYISHGSPMTALHPGQVGVRLAELARDLPTPRAIVMASAHWLGRQPLVGAHPQPPTIHDFGGFPRALFELQYPAPGDPALAEEVAGRIAAAGLPVALDPQRGLDHGAWVPLRLLRPQADIPVVPLSIQPLLGPEHQFALGRALAPLRDQGVLLVGSGSITHNLHDWGDYQDGKEAPYVRPFIEWVEQRLAANDRQALLDYRRQAPFAERAHPTDEHLLPLFFAMGAAGEDGFGARRIDAGIDAGFLAMDLYRFDGA
>NZ_CP040438.1|WP_106466942.1|571958_573608_+|Na+/H+-antiporter
MHTIEVVLAMLVAVVASGYLVRVLPFSLPLPLVQIGLGAVIAGVFNRGHALEPEVFFLLFLPPLLFLDGWRIPKQGLFRDKGAILELAFGLVVFTVIGAGFLIHWLIPVMPLAVCFALAAIVSPTDPVAVGAIASKAPIPKRLMHILEGESLLNDASGLVCFRFAVAAVMTGTFSLATASLTFVWVAVAGLAVGVAVTLGVSTFQRWLWRRFGEEPGAAMLVNLLIPFAAYLLAEEIHASGILAAVAAGIAMSYVELTGRVSGSMRVQRAGVWNMLQFSFNGIMFVLLGEQLPGIVERATTTMNETGHQSAWWLLVYVVVINLALVVLRLLWVWLSLRWNLLRARRRGLERGEAPNWRIVVATSVAGVRGAITLAGVLTLPLFLPDGSAFPARDLVIFLAASVILFSLLGASIALPRLLKGLQLPSDSGERKEEDLARRLSSKAALAGVERMRQQMVMNQNTENVQLYNDAASRVSLLYQRHLEKDSDGPDVDPDKVRRMEQGYRQLRSAGLNAEREELFRLTRRGVISDEISRRLIRNLDLLESRKRD
>NZ_CP040438.1|WP_049456360.1|573689_573938_-|DUF3297-family-protein
MSDTPPDHLAINPASPFHDAQALERGVGVRFNDVERDNVEEYSVSEGWIRVQAGKARDRRGNPMTIKVKGKVEVYFLETKPE

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Crispr_ID: NZ_CP040438_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_3

768986-769085

Orphan

Consensus_repeat	Method
GGTAGGTGCCAACCTTGGTTGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040438_3

>merge|NZ_CP040438|3|768986-769085|CRISPRCasFinder
GGTAGGTGCCAACCTTGGTTGGCACGAAACCGCCGACCAAGGTCGGCTGCTACCAGAGCGTGCCATTGCCTCTTCGGTAGGTGCCAACCTTGGTTGGCAC

>NZ_CP040438|3|3|768986-769085|CRISPRCasFinder
GGTAGGTGCCAACCTTGGTTGGCAC	GAAACCGCCGACCAAGGTCGGCTGCTACCAGAGCGTGCCATTGCCTCTTC
GGTAGGTGCCAACCTTGGTTGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_154262311.1\|778352_779861_+\|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	unknown	unknown	gnl\|CDD\|234660
NZ_CP040438.1\|WP_154262302.1\|764272_767203_+\|autotransporter-outer-membrane-beta-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|273608
NZ_CP040438.1\|WP_154262295.1\|753687_754200_+\|fimbrial-protein	unknown	unknown	gnl\|CDD\|226069
NZ_CP040438.1\|WP_154262301.1\|761159_764117_+\|autotransporter-outer-membrane-beta-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|237940
NZ_CP040438.1\|WP_154262299.1\|756867_759408_+\|fimbria/pilus-outer-membrane-usher-protein	unknown	unknown	gnl\|CDD\|225729
NZ_CP040438.1\|WP_154264902.1\|760578_760989_+\|fimbrial-protein	unknown	unknown	gnl\|CDD\|366088
NZ_CP040438.1\|WP_049448901.1\|769500_769896_-\|YraN-family-protein	unknown	unknown	gnl\|CDD\|237119
NZ_CP040438.1\|WP_154262297.1\|754262_754673_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_049399810.1\|776511_778356_+\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|223839
NZ_CP040438.1\|WP_154262300.1\|759442_759952_+\|fimbrial-protein	unknown	unknown	gnl\|CDD\|185196
NZ_CP040438.1\|WP_154262308.1\|773133_773613_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378440
NZ_CP040438.1\|WP_154262298.1\|755940_756456_-\|fimbrial-protein	unknown	unknown	gnl\|CDD\|226069
NZ_CP040438.1\|WP_154262306.1\|769858_771580_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|367906
NZ_CP040438.1\|WP_005412242.1\|776251_776515_+\|cell-division-protein-FtsL	unknown	unknown	gnl\|CDD\|225658
NZ_CP040438.1\|WP_005412235.1\|771661_772480_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NZ_CP040438.1\|WP_154262309.1\|775286_776255_+\|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH	unknown	unknown	gnl\|CDD\|234597
NZ_CP040438.1\|WP_004143635.1\|774825_775272_+\|division/cell-wall-cluster-transcriptional-repressor-MraZ	unknown	unknown	gnl\|CDD\|234728
NZ_CP040438.1\|WP_154262303.1\|767288_768674_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NZ_CP040438.1\|WP_154264901.1\|755160_755868_-\|fimbria/pilus-periplasmic-chaperone	unknown	unknown	gnl\|CDD\|236634
NZ_CP040438.1\|WP_154264903.1\|773713_774502_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377554

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_154262311.1\|778352_779861_+\|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	gnl\|CDD\|234660	PRK00139, murE, UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional.	0
NZ_CP040438.1\|WP_154262302.1\|764272_767203_+\|autotransporter-outer-membrane-beta-barrel-domain-containing-protein	gnl\|CDD\|273608	TIGR01414, Contains:_AIDA-I_translocator, outer membrane autotransporter barrel domain. A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	7.44991e-69
NZ_CP040438.1\|WP_049399810.1\|776511_778356_+\|penicillin-binding-protein-2	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	1.98236e-169
NZ_CP040438.1\|WP_154262295.1\|753687_754200_+\|fimbrial-protein	gnl\|CDD\|226069	COG3539, FimA, P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion].	6.11052e-08
NZ_CP040438.1\|WP_154262301.1\|761159_764117_+\|autotransporter-outer-membrane-beta-barrel-domain-containing-protein	gnl\|CDD\|237940	PRK15313, PRK15313, intestinal colonization autotransporter adhesin MisL.	6.88644e-77
NZ_CP040438.1\|WP_154262299.1\|756867_759408_+\|fimbria/pilus-outer-membrane-usher-protein	gnl\|CDD\|225729	COG3188, FimD, P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion].	0
NZ_CP040438.1\|WP_154264902.1\|760578_760989_+\|fimbrial-protein	gnl\|CDD\|366088	pfam00419, Fimbrial, Fimbrial protein.	3.38774e-07
NZ_CP040438.1\|WP_049448901.1\|769500_769896_-\|YraN-family-protein	gnl\|CDD\|237119	PRK12497, PRK12497, YraN family protein.	1.64922e-48
NZ_CP040438.1\|WP_154262309.1\|775286_776255_+\|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH	gnl\|CDD\|234597	PRK00050, PRK00050, 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH.	2.24591e-168
NZ_CP040438.1\|WP_154264901.1\|755160_755868_-\|fimbria/pilus-periplasmic-chaperone	gnl\|CDD\|236634	PRK09926, PRK09926, fimbrial chaperone.	3.17755e-60
NZ_CP040438.1\|WP_154262300.1\|759442_759952_+\|fimbrial-protein	gnl\|CDD\|185196	PRK15296, PRK15296, fimbrial protein SthA.	3.9404e-07
NZ_CP040438.1\|WP_154262308.1\|773133_773613_-\|hypothetical-protein	gnl\|CDD\|378440	pfam10517, DM13, Electron transfer DM13. The DM13 domain is a component of a novel electron-transfer system potentially involved in oxidative modification of animal cell-surface proteins. It contains a nearly absolutely conserved cysteine, which could be involved in a redox reaction, either as a naked thiol group or through binding a prosthetic group like heme.	9.95852e-18
NZ_CP040438.1\|WP_154262298.1\|755940_756456_-\|fimbrial-protein	gnl\|CDD\|226069	COG3539, FimA, P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion].	4.48521e-21
NZ_CP040438.1\|WP_005412242.1\|776251_776515_+\|cell-division-protein-FtsL	gnl\|CDD\|225658	COG3116, FtsL, Cell division protein [Cell division and chromosome partitioning].	5.9001e-29
NZ_CP040438.1\|WP_005412235.1\|771661_772480_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	5.3592e-126
NZ_CP040438.1\|WP_004143635.1\|774825_775272_+\|division/cell-wall-cluster-transcriptional-repressor-MraZ	gnl\|CDD\|234728	PRK00326, PRK00326, transcriptional regulator MraZ.	2.46988e-55
NZ_CP040438.1\|WP_154262303.1\|767288_768674_-\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	9.32949e-138
NZ_CP040438.1\|WP_154262306.1\|769858_771580_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|367906	pfam04348, LppC, LppC putative lipoprotein. This family includes several bacterial outer membrane antigens, whose molecular function is unknown.	3.70351e-109
NZ_CP040438.1\|WP_154264903.1\|773713_774502_-\|hypothetical-protein	gnl\|CDD\|377554	pfam05742, TANGO2, Transport and Golgi organisation 2. In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation. In plants this family includes Solanum habrochaites Cwp, which is involved in water permeability in the cuticles of fruit. Mouse Tango2 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.	2.00198e-82

>NZ_CP040438.1|WP_154262303.1|767288_768674_-|FAD-binding-protein
MSPALPAALVAELSALLGAEGWRMDDNTLEANAQDNSWRRQRPAAVVLPADIEQVQALVRACRAHGVALVARGAGTGTTGAAVPLPGSIVLSFTRMDRIVEIRAGDRCAVVQPGVLNGTLQQALAPHGLFWAPDPSSAEICSVGGNLACNAGGPRAVKYGTSRDNVLGLVAVTGAGEVIRCGGAYTKDATGYDLTHLLVGSEGTLALIVEATLKLTPLPVSQAGLRVLYRDADAAAAAVSRLMSQPVVPTRLEFMDARSLELLRLNGADVPEAGAMLLVEADGDHDTLPYLLQALASAAEGDGMIALDVAMEGRARDQLWAARKALSPALRSVAPGKINEDVVVPVSRIPDLVSGVQALARDYTLTIVTFGHAGNGNLHVNILYHPDDADENARAHAALPKIFELTLALGGTLSGEHGIGLAKRDFMAKAFTAETLAAMRAIKAALDPDGILNPGKVLPPA
>NZ_CP040438.1|WP_154262302.1|764272_767203_+|autotransporter-outer-membrane-beta-barrel-domain-containing-protein
MRPPHVRCSALSLALAAALATSLPLEASAQQVIADGDEQTPAAGDYIATGVGNHAFHALNGGSIVPLGPVTVSASGDGASAARAEGAGSRIELTGSALITTGFGATTALATAGGEMHLTATEVINKGTGMGVVAHTGSQATLQDVNIRMEGVSSVGLAGGGDITMTGGSISAMGLGSRAVSATGANMVLSDVAIEGESGIWLQDNNQLELAGSTVSAKGIALDINGRGNTVTVADSTLHSTGNGVGTVVMFADSTLAMSRSAIISEGDRAVGIDVRGGTADLERVDVTTSGESSHGLYADFTTIGARATINARAAQVHTSGTGAIGAVARQGGSIHLDDSIIRTEGQQAHGVLTGGSGGMTLTDTHVRTEGEGAWAAVINDNGSLGIDGSALESVQHGGVWVRSSRDAGLTLSNNAYVSGGNGIAIALDAAVAGRFDVVLERRSQMVGDIVITPEDEDAGLVPQSDVHVRLADGSLWQGTSNLVQTMAIESGSQWTLTGDATVGELSVLNSGVALSDGSGRFNTLTVDGDLNSEGATFLFQGALGGDDSAFDRLHVRGDTSGDASIAVKNMGGVGAQTTDGIQLIEVDGASLATYALAGRAVGGSYEYFLFQGGLIDPNDGNWYLRSQWFDVCADDPNAPGCVVDPGPGPGPDPGEGGEEGGGGDPVRPPPVLRPEAGAYLANQSAALNMFAHRLNDRIGAVSLDEGRAAWARVGRQQADFSAVGGQLSIDGNTSVLQIGSDLLRRGNAAFGVMLGTGRADSSAVSGLTGYSAKGRVRGSAVGAYGTWLQAADGTQGAYMDANLQYGRFDNRVQGIGLEPEHYDSRMASASLETGYTFNVWQGTASALYVQPQLQLNYVDFRADRHVESNGTVIDHADAGGLSGRLGVRVFGHGTAAGNTVQPYLGINWLRGSGTSTLQFNGDTLGADVPRNRYEVQAGAELKLGQRWGAWGGLSVQRGDYGYRNVGGQLGLRMAW
>NZ_CP040438.1|WP_154262301.1|761159_764117_+|autotransporter-outer-membrane-beta-barrel-domain-containing-protein
MQSLRTRPHLLALALASVLAAPVALAQQVIADGTAQTPAAGDYSATGVGNHAFHALNGGSIVPLGPVNVSASGDGASAARAEGAGSRIELNGATLVTTGFGATTALATTGGELQLTAIDVLNQGTGMGVVAQTGSQATLQDVNIRMEGVSSVGLSGGGNITMTGGSISAMGLGSRAVSAIGATMALSNVAIEGASGIWLENNNRLDLAGSTVKANGIALDINGFGNTVTVSDSTLHSTANGTGTVTMFADSTLAMAGGAIVSEGDRAVGIDMRGGSADLERVEVTTSGESSHGLYADYTTFGTRPGINARAVQIHTSGSSAIGAVARQGGSIQLQDSVIRTEGQEAYGVLAGGSGAMTLTNTDVRTEGEGAWAAVINNSGSLRIDGGSLESVQHGGVWVRSSRDAGLTLANGAQLTGGNGTALALDAAVAGRFDVRLEDGAQMDGDVVIHPDDVAAGLVPQSEVHVALDAASLWSGGTTLAQTVALAGGSQWTLQGASEVGALSLDDSALVLGTDARGGVGTLTVTGNLTTTGARLMFRGALADDASELGHLHVLGDTGGDASISVENLGGSGAQTVDGIELIKVDGASLGTYTLSGRAVAGLYEYLLHKGGVAGGDGNWYLRSAAIDPCEVDPTGPGCTPVIPDPCEVDPTGPGCTPVIPDPCEVDPEAPGCTPVIPEPILRPEPGAYLANQVAAVDMFQHRLHDRRGEPSFAHGRGAWARVSQQQPQITTLGQQLSVRGSSAVLQIGSDLFQREGVALGVMLGSGRSNSTVASDLTEYRARGRVRGTAVGIYGTWLQDPAQGGGLYLDSSVQYARFDNRVEGDGLARESYDSRAGIGSLEGGYTFNVWQGVSSNLYVQPQLQLSYVDYRADRHVERNGTVVDNDDAGGLGGRAGVRVFGRSTREGNLVQPFVGVNWLRGSRTSTLDFDGETLAADVPRNRYEVQAGAELRLGNSWGAWAGLSVQRGEQEYRNVAGQLGVRRTW
>NZ_CP040438.1|WP_154264902.1|760578_760989_+|fimbrial-protein
MKFPAATCPLQDKAETLQDVQTAELSVPGSTAKEKLVAIRMDCGADAPRARMTLSDAGDASNTGSQLTPTADSDAEGVRVQLLRNGSEVQFGQTWDFEPGVGGVHDHQFTARYIRTNETLVPGTIKGEAVLNVDYW
>NZ_CP040438.1|WP_154262300.1|759442_759952_+|fimbrial-protein
MNLFNRIAFATALLAAAPLALADQATLTISGRVLPGTCTLNAAPIALDAVKASDLTPGTDAQIKAGALEFTGCVGVSKAVLSFDGTPADGDAERWKNTAATDPASGVSISLLSGTTGNTYLKDGDTGIDVPVTGATARYDLRAAYHAPTGAALSAGEVSTEIVVTAAYE
>NZ_CP040438.1|WP_154262299.1|756867_759408_+|fimbria/pilus-outer-membrane-usher-protein
MKKRSVAPHSSSTPASRPLGLAIAAALSLWLVGPVHASDAENLEFSAGFLIGGQSIDLQRYVQGNPMEPGVYPLDVVVNGQFHEKRDITFVADASAQGATPCLPAGLVRQLGLKQSYLDALDEDDDSCVALADLVAGATVELDSSDLQLRVNVPQAAQARNARGYVAPAQRDHGITAAFFDYNVNHNRSAGQNASYLGLNTGVNLGAWRLRHRSSFSQGSFGTRHDVISSYAQRDLPAWNSQLLLGQGNTGGELFESLSFTGVRVASDERMLPDSLRGFAPVVQGIAEGNAVVTIRQNGNIIHEVSVAPGPFSIEDLYPTSFGGDLQVTVTEADGRQQNFTVNFSAVPQALRPGASRFSATAGELRDARGLRESLRFAEGTYARGISNHFTALGGLQVAEDFQSALFGGAINTPLGAFGADVTHSRARLANGEQITGNSFRLNYQRYVAATGTNFGLAAHRYSTRGYLSLNDFAQARADDWGYSGRARQRFQVNFSQRIGERSTLSLSGGHVRYWDGAAAQNDLQLRFQSTVGRANYSLSAVRYRQGDGRQDTRYSATFSIPLGKAPSAPRLSTQLAQSARGEQGQLGVSGTLGADQQLNYNVSASTASEGASSASAYASYRGGHGTVTAGYNRSGDYSAFNASAAGSVVVHRGGINFGAPVGDGFALVQADGAQGARIGYGSDVRIGRNGYALLPHVSPYRWNQIELDPSGLSMDVELLQTSQRVAPTAGSIVRVAFNASRQRTLFIDATDALGQPLPFAARIEDESGRSVGAVGQGGVIQLRGAPDHGQLIVDPDGPQRCRLEYTTPDAPDAYGLSWSQAVCTPLPPPSTGLQAALKAADATSL
>NZ_CP040438.1|WP_154262298.1|755940_756456_-|fimbrial-protein
MSNRMNLIAASALALALSPAASAEKLEITGELMTSTCLVDATGGTVTVPMGKVDVASVNAADRAGMKNFSILLDCTGSGAPQKVGVRFGGTPDGSTGNLALDAASSATNVGVALYDAAGNQQKLGEDPLQWVDIPAAGSGQLDYSAWYSSPGRNATAGSANATGDFVVLYD
>NZ_CP040438.1|WP_154264901.1|755160_755868_-|fimbria/pilus-periplasmic-chaperone
MTWMTALLAGALALPASAAVTLQGTRIVHDAAKGRDVTVRATNSGEKAAMVQVWIDDGDSHARPENVRTPFRLTPADPRLLQAHQGQAYRVTYAPRPSEAPLPTDRESVFYFNMLDIPPKPADAAGKNLLQFAVRTRVKLFHRPAGLPGNARDAAGQLQWRAQAGALLVSNPSAYHVTVSTLTLPDGRKVEAEMIAPGAQVRLPLPSGAAIPASVTFQWLDDYGTPRDAEAKISP
>NZ_CP040438.1|WP_154262297.1|754262_754673_-|hypothetical-protein
MTAAHYPYLYATLGETANQLPDDLARTLETTLCSLQAGAAADGVTLLGCLRTIHEVDAADGQLLPSAGRTQSQRWALSRIDRANAGLTFLVELLQASERVRVDGDESQQLDDGAREALLLACRGLCEYVGMQVHAA
>NZ_CP040438.1|WP_154262295.1|753687_754200_+|fimbrial-protein
MKSLALRTATFTALAALAPLASADTATITISGRVLPGTCTLSAAPIALDPVKASDLTPGEDTGIKAGALEFSGCVGVSKAVLSFAGTAADGDAERWKNTAASDPASGVSIALLAGTTGNTYLKDGDTGIEVPVTGASARYDLRAAYFAPVGQARVAGEVSTEIVVTADYQ
>NZ_CP040438.1|WP_049448901.1|769500_769896_-|YraN-family-protein
MAAGRCRSSVVAERSQRGSAVEAAAEQHLQQAGLQPRARNVRYRGGELDLVMDDAGTVVFVEVRYRARSDFGGGAASVDARKCRRLAHAAQLYLQDNPALANAPCRFDVVDATGEPPQLRWLRDAFRLDDC
>NZ_CP040438.1|WP_154262306.1|769858_771580_-|ABC-transporter-substrate-binding-protein
MNKPAARISALSLSLMLLAGCATTSLTSTPDSPAQSQALALIEQGKPRDAALQLEGLAATLRGGARSNALADAAWAWHLAGDSARAGSLLGQLTARQLSGASLQRYQLTGAELALADKQPAQALALLKDHGDNVLPTLRTRWYLARANALQGTGDAFGAATERARAHASLTGSARSENQAAIAGLLGTLDDATLRSRAAALPANDPLYNFAGRALIARGLPLPRPFDRDGAAQFDTSKRPPAMSDGYRPPAKLAVLLPLSGRLATAAQPVRDGMLSAYYGESRRRPDINFFDTAGTPAGALAAYDKAVASGADFVVGPLGRDEVDAVYGRQQLQVPVLALNRGKDAPPAGSAGFSLAPEDDGIVAAEYLRGRERNRALVISSNDDTGRRSAAAFAQRFAQRGGQVVATVNVSEAVGDVGAQVRNAGQVDAVFLAVRAPQARLLAPQLALAGAGGATRVGTSQLTVGSGKVEEDVALDGIVYPNEAWNVRSVSGLPSASQVASALPSARGAAGRLFAFGADAWKITAYLDKLSNEGGLDGATGTLFLDSNGNILRQPAWSTFSGGRPMPIVGGR
>NZ_CP040438.1|WP_005412235.1|771661_772480_+|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MSVPTLYVVATPIGNLADLSPRAQEVLRSVAAICAEDTRRSGQLLSHFGIQQPLVALHEHNEEALAQRLVSRLQAGESLALVSDAGTPLVSDPGFRLVRAARAAGIKVSPIPGACAAIAALSVAGLPSDRFSFEGFLPAKASGRRDRLQALAGEVRTMVFYESSHRIAESLADMAAIFGGERPAVLARELTKLFETVLDGDLAGLLAKVEADENQRKGEFVVMVQGAGDDEEAQLAHGRRVYAKLSEHLPPSTAAKLAAELTGAPRKALYGS
>NZ_CP040438.1|WP_154262308.1|773133_773613_-|hypothetical-protein
MRRVLVLVVTHLLALGLGFGLGIYLLPILIAPDDPPVAQVQAAMGDARYHTTFRRDLKGSDAVHWAEGKVSVSPRQVAFNGKMGPGPDYKVYLVRDFVDNKADFLEIKAQAQRIGEVKTFNRFLVDVPDDVNVDDYTTVVVWCERFSQFISAGQYRTPS
>NZ_CP040438.1|WP_154264903.1|773713_774502_-|hypothetical-protein
MCLLALGWMHHPRWRLVMTGNRDEFHARPTAALAPWQDETSVIGGRDLRSGGGWAGVGASGRMAVVTNVRDPLAAQTGPSRGALVADFLRGRDPAAVHIDRLATVAGAYAPFNLLLADGRSLEFLGNHPAERQSLGPGVHGMSNGALDAPWPKTRRLMAALEAWLQEDRVRSLSQSERDLTPDLTPLWAALADEHRPADSDLPDTGIGLERERWLSPAFIRGDDYGTRASTVLLIDADGHGEIHERRFGPQGVALGQSRVDF
>NZ_CP040438.1|WP_004143635.1|774825_775272_+|division/cell-wall-cluster-transcriptional-repressor-MraZ
MFQGETAITVDDKGRMAVPTAYRDLVARASNNRLVLTYNPFEAGCLWLYAESEWERVRDDVMSKPNTQRVVRLLQQKLVGSAAHLELDGNGRISIPASHRGAVGIEKKAVLLGMGDKFELWSEQAHRALIQQTLSDEDLGDGLLDLKL
>NZ_CP040438.1|WP_154262309.1|775286_776255_+|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH
MRPEAQAGHLPVSQSPAVHLPVLYTQVLEGLRVIENGRYLDGTFGRGGHARGVLTQLGPEGRLLVMDKDPEAIAVAERDFAPDPRVSIFRGSFAQLLQWDATAEGLDGVLFDLGVSSPQLDVAERGFSFGKDGPLDMRMDPDSGESAAQWINRVEEREIADVLWTYGEERQSRRIARAIVARREKQPFTRTAELAELIASVMPRGKDKIHPATRSFQAIRIHINRELADLEAGLDAAVERLKPGGRLAIISFHSLEDRIVKQYMNRLAKAPPANRRLPEAEVFVPTLDLIGGAIKATDEELAANPRARSAVLRVAQKREADA
>NZ_CP040438.1|WP_005412242.1|776251_776515_+|cell-division-protein-FtsL
MSRLLLIILLASTVASAIGVVFVRHRHRQTFIELSRAERKRDDINLEFGRLQLEQATLAEANRVDRIAREKLGMKFPEAADIVVVRP
>NZ_CP040438.1|WP_049399810.1|776511_778356_+|penicillin-binding-protein-2
MSKTGRNRPRNAFNLRQRLRWVALALGLCSVSLVGRAAYVQIINSDFYQRQGEARYLRELPIKTSRGMITDRNGEPLAVSTPVASIWVNPQDLLRSPERIPELAQAVGMSVDELSSRLSQKSDKEFMYLRRRINPDEAEKVVALKIPGVAAQREFRRFYPQGEAMAHVLGFTNIDDRGQEGLELAFDEWLRGKAGAKRVIRNRKGETVESDLLRAAEPGKDLTLSIDRRIQYLAFKELRNALVANKAAGGSMVIMDVTTGEILAMVNLPTYNPNSLTGALPDARRNRAVTDLVEPGSTMKPLTIATALQAGAVTKDTIIDTNPGYMQVARFTIRDVPRNNGVLNVTGVITRSSNIGAAKVAAKMPDQVFYDGVRRFGYGSVPHSGFPGESGGVVRRPANWDGATKTTMSYGYGLNVTPLQIATAYSALANGGKLIAPTFVKGQRNEAHQIIDESVARQVVAMMETVVTQGGAKQAAVLGYRVAGKTGTARKTGPGGYERGHYNALFAGVVPATNPRFATVIVINDPQAGKFYGGLVSAPVYHNVMEGTLRLMDVPLDDLQSWLAAQQSGKVGHSASILPAPPAEAALPVDAAAEFDAALPSAQAQTPPATGGTQ
>NZ_CP040438.1|WP_154262311.1|778352_779861_+|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase
MSPSMLLSQLLPDVALAGHDPVLTGLVLDSRAVRPGNAFVAIAGFGAHGLGFVEQARAAGAGVILFEPPAPADLPAPADAIAVPGLRARMGAMADQFHGAPSRAMAMVGVTGTNGKTSTVQLLAQAWHLLGTPSGSIGTLGAGLYGSAEPTGFTTPLVLQMHALLAQLRDAGARAVAMEVSSHALDQGRVDAVHYDVAVFTNLTRDHLDYHGDMASYGAAKARLFHRPGLKAAVVNLDDAFGRQLFAGLPAGVQPIGLSSRGVTDASVRAEALQLDGRGIAFELVIDGQRAAVQSPLLGRFNVDNLLAVAGTLHAQGQPLPRIAEVLSALQPIRGRMNRLGGEDGLPTVVVDYAHTPDALEQALDSLHGHLQGTLFCVFGCGGERDTGKRPQMAAIAERLANQVIVTDDNPRGEDGDVIVADILAGFTDASAVTVQRSRARAIGLAVKRAGAGDIILIAGKGHEPYQEVNGVRHDFDDTEVAAAALAAKAGVLSAQAGEGIA

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Crispr_ID: NZ_CP040438_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_4

1420883-1421020

Orphan

Consensus_repeat	Method
TTGCCGGCCAGCGGCCGGCACTACCGA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP040438_4

>merge|NZ_CP040438|4|1420883-1421020|CRISPRCasFinder
GTGCCGGCCGCTGGCCGGCATCCCCGTGAGCCCGGGAACAATGAGGTTGCCGGCCAGCGGCCGGCACTACCGACTCTGCCTGGGTCTGGTAGTTGCCAACCTTGGTTGGCATTGCCGGCCAGCGGCCGGCACTCCCGA

>NZ_CP040438|4|4|1420883-1421020|CRISPRCasFinder
GTGCCGGCCGCTGGCCGGCATCCCCGT	GAGCCCGGGAACAATGAGG
TTGCCGGCCAGCGGCCGGCACTACCGA	CTCTGCCTGGGTCTGGTAGTTGCCAACCTTGGTTGGCA
TTGCCGGCCAGCGGCCGGCACTCCCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_154262819.1\|1418751_1419420_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154262818.1\|1417955_1418576_+\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NZ_CP040438.1\|WP_012479558.1\|1427000_1427360_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|185011
NZ_CP040438.1\|WP_154262820.1\|1419416_1420205_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NZ_CP040438.1\|WP_154262830.1\|1426605_1427004_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|307170
NZ_CP040438.1\|WP_154262832.1\|1429653_1430337_-\|response-regulator	unknown	unknown	gnl\|CDD\|182612
NZ_CP040438.1\|WP_154262823.1\|1421056_1421941_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154262831.1\|1428277_1429657_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP040438.1\|WP_154262822.1\|1420490_1420850_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319937
NZ_CP040438.1\|WP_154262814.1\|1413298_1414486_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NZ_CP040438.1\|WP_154262829.1\|1425392_1426595_-\|nucleotide-sugar-aminotransferase	unknown	unknown	gnl\|CDD\|99740
NZ_CP040438.1\|WP_154262825.1\|1421944_1423009_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225688
NZ_CP040438.1\|WP_010483180.1\|1427361_1428198_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224561
NZ_CP040438.1\|WP_154262826.1\|1423038_1424439_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223238
NZ_CP040438.1\|WP_154262817.1\|1415476_1416877_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NZ_CP040438.1\|WP_154262821.1\|1420209_1420422_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|314732
NZ_CP040438.1\|WP_046983255.1\|1416955_1417849_-\|ArgP/LysG-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|235144
NZ_CP040438.1\|WP_154262827.1\|1424501_1425218_-\|MtnX-like-HAD-IB-family-phosphatase	unknown	unknown	gnl\|CDD\|319826
NZ_CP040438.1\|WP_154262812.1\|1412174_1413302_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NZ_CP040438.1\|WP_154262815.1\|1414470_1415484_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|224482

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_154262818.1\|1417955_1418576_+\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	3.72726e-62
NZ_CP040438.1\|WP_154262820.1\|1419416_1420205_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	1.31923e-129
NZ_CP040438.1\|WP_154262830.1\|1426605_1427004_-\|EamA-family-transporter	gnl\|CDD\|307170	pfam00892, EamA, EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.	4.22605e-06
NZ_CP040438.1\|WP_154262832.1\|1429653_1430337_-\|response-regulator	gnl\|CDD\|182612	PRK10643, PRK10643, two-component system response regulator PmrA.	1.64546e-68
NZ_CP040438.1\|WP_154262821.1\|1420209_1420422_-\|hypothetical-protein	gnl\|CDD\|314732	pfam11903, ParD_like, ParD-like antitoxin of type II bacterial toxin-antitoxin system. ParD-like antitoxin is a family of archaeal and bacterial proteins of a type II bacterial toxin-antitoxin system. Many of the cognate toxins for these molecules fall into family ParE-like_toxin, pfam15781. Gene-pairs are expressed from the same operon, the toxin of the pair being expressed first, eg, for UniProtKB:Q3AQ93 and UniProtKB:Q3AQ94.	2.37948e-27
NZ_CP040438.1\|WP_154262831.1\|1428277_1429657_-\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	8.47956e-51
NZ_CP040438.1\|WP_154262822.1\|1420490_1420850_-\|VOC-family-protein	gnl\|CDD\|319937	cd08349, BLMA_like, Bleomycin binding protein (BLMA) and similar proteins. BLMA also called Bleomycin resistance protein, confers Bm resistance by directly binding to Bm. Bm is a glycopeptide antibiotic produced naturally by actinomycetes. It is a potent anti-cancer drug, which acts as a strong DNA-cutting agent, thereby causing cell death. BLMA is produced by actinomycetes to protect themselves against their own lethal compound. BLMA has two identically-folded subdomains, with the same alpha/beta fold; these two halves have no sequence similarity. BLMAs are dimers and each dimer binds to two Bm molecules at the Bm-binding pockets formed at the dimer interface; two Bm molecules are bound per dimer. BLMA belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. As for the larger superfamily, this family contains members with or without domain swapping.	2.8048e-37
NZ_CP040438.1\|WP_154262814.1\|1413298_1414486_-\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	1.02217e-33
NZ_CP040438.1\|WP_154262829.1\|1425392_1426595_-\|nucleotide-sugar-aminotransferase	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	3.48502e-42
NZ_CP040438.1\|WP_154262825.1\|1421944_1423009_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225688	COG3146, COG3146, Uncharacterized protein conserved in bacteria [Function unknown].	1.8718e-07
NZ_CP040438.1\|WP_010483180.1\|1427361_1428198_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	6.07078e-47
NZ_CP040438.1\|WP_154262826.1\|1423038_1424439_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223238	COG0160, GabT, 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism].	5.34312e-110
NZ_CP040438.1\|WP_154262817.1\|1415476_1416877_-\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	1.35823e-37
NZ_CP040438.1\|WP_012479558.1\|1427000_1427360_-\|EamA-family-transporter	gnl\|CDD\|185011	PRK15051, PRK15051, 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional.	0.00873844
NZ_CP040438.1\|WP_046983255.1\|1416955_1417849_-\|ArgP/LysG-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|235144	PRK03635, PRK03635, ArgP/LysG family DNA-binding transcriptional regulator.	4.80485e-149
NZ_CP040438.1\|WP_154262827.1\|1424501_1425218_-\|MtnX-like-HAD-IB-family-phosphatase	gnl\|CDD\|319826	cd07524, HAD_Pase, phosphatase, similar to Bacillus subtilis MtnX; belongs to the haloacid dehalogenase-like superfamily. Bacillus subtilis recycles two toxic byproducts of polyamine metabolism, methylthioadenosine and methylthioribose, into methionine by a salvage pathway. The sixth reaction in this pathway is catalyzed by B. subtilis MtnX: the dephosphorylation of 2- hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HKMTP- 1-P) into 1,2-dihydroxy-3-keto-5-methylthiopentene. The hydrolysis of HK-MTP-1-P is a two-step mechanism involving the formation of a transiently phosphorylated aspartyl intermediate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.34879e-35
NZ_CP040438.1\|WP_154262812.1\|1412174_1413302_-\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	2.68196e-29
NZ_CP040438.1\|WP_154262815.1\|1414470_1415484_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|224482	COG1566, EmrA, Multidrug resistance efflux pump [Defense mechanisms].	3.21961e-36

>NZ_CP040438.1|WP_154262822.1|1420490_1420850_-|VOC-family-protein
MPQTVIPQLRMRHADTTLPFYVQGLGFVVDWEHRFEPGFPLFAQLTRDGQTIFLTEHSGDCEVGGAVYFIVEDVDALHRAFSAANVPIEQPPHDTEWGSREMLLRDPDGNRLRFATDAS
>NZ_CP040438.1|WP_154262821.1|1420209_1420422_-|hypothetical-protein
MGIVNIDDTLHDQLRRACTVSSRSINAQANFWIRVGMLCELNPTLSFQDIAASELRAAGVQPPLLAPGQV
>NZ_CP040438.1|WP_154262820.1|1419416_1420205_-|type-I-methionyl-aminopeptidase
MAIIKRPDEIALMAESGRLLAQVFAALDRLPLQGRSTMEINDFVERMIVDELQARPASKGQYGFPYVLNTSIDNVICHGVPSTTDVVRNGQIVNLDITLEKNGYIADSSTTYLVGEVDYAARRLVQTAYQAMWKGIAAVRPGARLGDIGHAIARHARSHGYSVVKEYCGHGIGQEMHEEPQILHYGRPNTGMVLEEGMVFTIEPMLNQGKPAIRQQPDEWPVYTRDGKLSAQFEHTVAVTRTGVRVLTLRPGETPLCAVDGT
>NZ_CP040438.1|WP_154262819.1|1418751_1419420_+|hypothetical-protein
MKDNLRLLLSHLGRTFLFGLMMALPPALAWLDIHWLGNAVGEWSLVELTQEGFLVASVAAFVRLALRRADDRAFAVLAAALFACMLLREMDEALDLIAHGFWKYPVAVLIIGSLAWASRDWRRAMQALVRFLVSRPGTVMTIGLVLLLFYSRLIGMTSLWTGLLGDQYIRVFKNTIEETTELLGYTFILAASVGYVAQRVREPLTARKRALHEGTGMQQRPL
>NZ_CP040438.1|WP_154262818.1|1417955_1418576_+|amino-acid-transporter
MWIAATAAGLFAGAGLIIAIGAQNAFVLRQGLQQRHVGRVVLACAGADIVLILAGVGGMGALVLQWPLLLQVLRFGGAAFLLWYGLQAGLRAWRGGSALAAAEAQGGSGRQVLMTCLAFTLLNPHVYLDTVVLLGSLSTRYPGDLRWAFAAGACAASVAWFCTLGYGARLLQPVFRRSGAWRVLDAGVAIFMFCLATLLLLRPLSP
>NZ_CP040438.1|WP_046983255.1|1416955_1417849_-|ArgP/LysG-family-DNA-binding-transcriptional-regulator
MDLVHPQLAAFAAVLEEGSFEAAARRLSISPSALSQRIKALEDRLGQVLVVRQAPCRPTAAGEALLRRVRPMQALEAEALAELLPERGSDAARTPIPLAVNDDSLDTWFVPAIAELHQRHGYLFDLRMDDQDHTLQLLRDGSVLGAVTAESQPVKGCNVHPLGAMRYHAVASPGFARQYFSDGMQAAALARAPMLVFNRKDELQWRFVRRLTRARLQPPLHYLPSSTGFVEAAACGLGWGMAPETLVAPAVRAGRVVVLEPRRWLDVPLYWQHAAVRSSTLQHITQALRTAASGTLR
>NZ_CP040438.1|WP_154262817.1|1415476_1416877_-|TolC-family-protein
MGVIGRRTRMHGAKAALALAACLPLASAAQPLTDAPALDWEQARQRLEQVSDALAAADAAVRNKQDLQDATRLLRLPEITGEVRRLQFQKTLTLPLGSLAPVAEAYGIDSPLSFTERDWRTRPVVTAVLPLYTGGVIPAAQRAASAAHEQASAEREAQRQSLTVQLAQAYFGQRLAEQAVDVRRDVRDGLNRHLSDAEKLEREGFATRAQRLQATVARDKAEREYQKTVNDLATLKAALATLLRSGGEVQPVSPLFVQRVPLEPVASFERTAQARQPQIARLRAMVAQAEQGVRVQQAKLKPQIFAFGQYDFRRRDEMLTDPDWAFGIGLKYTFLSPNSRPAQISAARAQQEQAEAGLREAENQVALGVRKAWNELETARQQFVLLDSSIAQAQENLRLQELAFREGQATSLDVIDARLGLGGARVERAQAAYQYDIALAQLLEISGQMDRFEEFRRRADEVIDHE
>NZ_CP040438.1|WP_154262815.1|1414470_1415484_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MSDVLHDDATTPPGKRRLGPILIVVLLIVVVLGLWLAWRSPADQIQGMADADTINVAAKITARVAELKVREGDRVQPGQVLFLLDSPEVAAKEQQAHGALAAAQAVADKADEGARSEDIRAAEANWKRAEAGATLAEATYQRVQNLFNEGVMTRQKRDEAHAQATSSRELARAARAQYDMALAGAREQDKRAAQGQVQQAQGAVAEVNAARVEVEGRAPVAGEINKRMADPGELVPAGYPVFTLVDIDRMWVAMNLRESQMQGLKVGSKLQGSVPALGQDGEFEVYFINPAGDYATWRTTRQSSGYDVRSFEVRVRPVRRIEGFRPGMSVLFAWPQH
>NZ_CP040438.1|WP_154262814.1|1413298_1414486_-|ABC-transporter-permease
MAPALSPDSSSFAASWRRELRSLRGNRADLLLVTLLPLLMLAVMAWMFTPSVMRDIPIAVVDLDHSSDSRLLLRMLDASPGVRIASQPADMQDARSQLRSLDVFAIVLVPRDVTRQALRGRQGTVFAYYNATYMTTGQSAARDIGDAISAWNARLLRERIGLQVGPGKLRAAPIAVQSDILYNPARSYELFLLPLIFPAVLSLVLALAVAGSLGREIRDGTLPAWLGRKPWLAIAGKVAPYILLFSLYGALGIGYLAWLRGDGVAGSVLLLLLAQPLFYLATAAYALFFVGVTRDMGTALSAVGLSIGTALAFSSATFPVLDGPLFTRVWHQLLPLSAYIKLQTQQQFIGSPLQVSVWPLTTLLLMSVVAGGIGALRLIAFARTPGAAQTAGADA
>NZ_CP040438.1|WP_154262812.1|1412174_1413302_-|ABC-transporter-permease
MSALWRSLRQTLMAVLCDRYAIVVMVGAVILYSFFYPAAYRHQVAGNLPVLVVDEDHSATSRELLRKLDALRVARVVGQPADIDSARQQLEAGHAEGIVLIPANLERDILRGHPAKLVLLGNGAYLGRASWVLGSVADALGAFGREAVVGQAAFMGAPQAPPVTLVQRPLYNTQEGYGSAIVPGVAELIVHQTLLMGIGVLLGGRRLALGRRLRFDLPTLAGMALGFGLIGLFGLFYYAGFTAWVQDYPRGGNPLGQLLGGTLFIAATVAFGLFVGSFLRTRERAFQYIIASSIPLFFLANLSWPAVMTPQPLVWLAQLLPTTSGINLMVRLNQMDARLAEVSHELITLTALLLLYGSLATWRLLAKKGTEGIKS
>NZ_CP040438.1|WP_154262823.1|1421056_1421941_-|hypothetical-protein
MPLRSPLILDLDGGVLPLPEAQTLALPQWHDPLRFACSNATLHRFSAEVLAPLPAQLGTVMLGSGDFHHLSLPLLQRMRTQAPFQLVVLDNHPDNMRFPFGMHCGSWVNAASKLPQISHIHVLGITSSDIGLGHAWENHWRPLIGGRLTYWCMDVDVGWGHRLGMGHAFRRFEHPEALVAAFAAEQATSPQPTYLSIDKDVFAEDVARSNWDQGRFQLEHALVVIEALRAGGLVGSDITGEVSLANYQSRFKRWLSSLDGQPDVGAEDLPVWQARHQQVNRELLAAMAAVPTAC
>NZ_CP040438.1|WP_154262825.1|1421944_1423009_-|GNAT-family-N-acetyltransferase
MEMTSRASSTALEPAALLEGFLAHPPLGFEAGRLPSGLPTFRAPLDLTTTMDDELRGKLLGLPLSRLWRPWITWQTRFIGATSTEYTPLPAHVAPGALAEDVTRHAIGDTRLLVVKDLAIDSPLLDDAANAHSGAFLQALLARGFVELEGMPLAWVAIDFDSLDGYLGRLSSSRRKNIRRKLRSRDDLQIDCIATGDPALADPQLQAELYALYLCVYAQSAVHFDQLDLPYFQYLLADSQGQGRMFLYRHQGQLIGWNLCYVHAGKLVDKYIGLAYPQSREHNLYAVSWMHNLEYALQHGLSHYVAGWTDSRIKAELGASFTSTRHAIHAHSPLLRAALRRLAPYLQGEPDGGG
>NZ_CP040438.1|WP_154262826.1|1423038_1424439_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MNIFDKNADAAASDAQLLADEARYSSFGDTVHYVDPPKIFQRGEGSYMFDGAGVPYLDLQMWYSACNFGYSNKRLNDALKDQIDTLPQVASQYLHPTRVQLAKTIAVDMHEKFGLDGRVHFNVGGAQAIEDSLKIVRNARGGKSLMFAFEGGYHGRTLGASSITSSYRYRRRYGHFGERAMFIPFPYPFRRPKGMTPDEYSDHCVWQFERLFESEYNGVWDPKVGQAEYAAFYVEPIQGTGGYVIPPRNFFTGLKRVLDKYGILMVVDEIQMGFWRTGKLWSIEHFGVTPDVLVFGKALTNGLNPLSGLWAREELINPTVFPPGSTHSTFNSNPLGTRLGLEVLKLGKEMDYERTVPEKGAYFLDGLRGLQRRHPEIGDVDGLGLALRAEICQTDGYTPNKELLDRMVDIGLAGDLLHDGKRMGLVLDVGGWYKNVITFAPSLDISYEEIDLAITLLDQALTRAKG
>NZ_CP040438.1|WP_154262827.1|1424501_1425218_-|MtnX-like-HAD-IB-family-phosphatase
MHWSILCDFDGTISLEDVIDSLLEKYGQPGWQELEDQWKAGKIGSRECMQGQVRLLKLDPATLDAQLDQVQIDPGFAAFVSRAEQLGVPLRIVSDGLDYAIHRILANHGLSRLPVVANHLRWCDDHWELESPYQAEGCRSGTCKCTCAAQARANEAPRVLMIGDGSSDFCVSEDADFVFAKRRLITHCTKAGIEHAAIDTFHDAVALLPRLLDGSLLQPRRIDASPQPAVLPLLLATA
>NZ_CP040438.1|WP_154262829.1|1425392_1426595_-|nucleotide-sugar-aminotransferase
MSLFARELPPTAGLPMQASDFLPGGGDLRDILASQLGTPPLQLTCSGTHALLIALRTLRKRAPKRDTVILPAYTCPLVPIAVHSLGLRVQLCDTRRGHFDFDPGQLKRLADARTLAILPTHLGGRIADVELANDIARGAGAWVIEDAAQALGARVGNSSVGLRGDIGFFSLAAGKGLSLHEGGLLVSRDDELRAALAEHAVQHVRSSLRWELLRSVQLMGLAACYRPALLSLVYGNPLRNALQRGDLEEAVGDIFPRDIPQHRVSQWRQNIGAHAARRLPAFLQAGRLRALQLRVQLAQLPAVEVVDGLAGSGGTWPLLMLLLPSQRARDAVLKDLWPRGLGASRMFIHALPGYAYLRGIVPQDDMPNARDFAARMLTLGNSAWQTREETAEILRALARA
>NZ_CP040438.1|WP_154262830.1|1426605_1427004_-|EamA-family-transporter
MRRLYVIGFPLLMAFDTLAQLCFKYAGDAALPVEANTAWLLRVLSQLWVYGAILGYVGAFFTWMSLLRHAPIGPAFAASHLEVISVLLLSAWLLNEPLTLHHLLGAVLIVAGIVCLGRAEADDPHSPAESTP
>NZ_CP040438.1|WP_012479558.1|1427000_1427360_-|EamA-family-transporter
MGALATLLWLANVVLDTGGQLAFKAAASDPQEGEGLQRWKHMLSRPWLWIGIACYVLEFVAWIAFLSLVPLSKGVLLGSINIVALMIAGRFLFREKLTPLRVTGMLLVTAGVAVVGAGS
>NZ_CP040438.1|WP_010483180.1|1427361_1428198_-|alpha/beta-fold-hydrolase
MTESHDFFLPGGPQGVLLVHGLTGTPAEMRMLGKGLNNAGFTVHGVQLPGHCGSVDDLLATTWEQWYQGVEDAAATLRGKVDQLFVGGLSMGAVLSLALAARRPEWVSGVGVYGATFRYDGWNIPAVARFSFLLPWFKRFNIGRDRMFMEEPPYGLRDERLRAQVSAAMLSGDSAAAGLPGNPWHALAEMRALSNWTRRHLHQVTAPCLVMHAREDDVASMGNAELVMSRVSGPKELVVLEDSYHMITIDRERRDVIRRSARFFTEIGERTGVLKAVA
>NZ_CP040438.1|WP_154262831.1|1428277_1429657_-|sensor-histidine-kinase
MISGPPSLRRRLLAFLALPMLGLLTFNTILAYYVALDYSNRIHDRNLIDDTHSFAQMLSAMPVTSDLSPQARFLIEYDPDGHRYFNVDSSRMGTLSGNADFSPYAPSQDCTGVHPALYDGTLNGQQVRMATVCTQAMNDPQDQLAVTVAESMADRRQRAREILMIIIPLMTMLALGTAALVWFGVTYGLRILTPLRTRLAQRRGELAPISDADVPEEIQPLISTIDDLFARQAEMITLQNRFIADAAHQLRSPLAGMALHVDQALAHGDPDTVREALQHIRRLNQRTARVSTQLLALSRAQTVPDTVEALDLCELVPQWVGIRVPEAIRDGIDLGYRGSPHPLRVLGNGAMLQEALDNLIDNALRYAGRNATVTVGVHALDDNDVELYVEDNGPGVPDDVMPRLGERFFRAPGTAASGTGLGLAIAHETVEHFGGRLSFLNRPGGGLKVAITLPLLKAP
>NZ_CP040438.1|WP_154262832.1|1429653_1430337_-|response-regulator
MRVLIAEDDPDIASGLCASLRRQGHVVDHVDNGAHADTALGSTQYALLVLDLGLPQLDGRDVLQRLRQRGDGLAVLVVTARDGLAERVRVLDLGADDYLVKPFALDEFEARVRAQLRRVTSNGNPDLRIGRLRIDLAGHRVWIDDQPLELTAREFGLLSALAVRAERIVSRAQLVEALCDWGQDLTDNGLDIALHRLRRKLQPGGMGIRTVRGLGYMLEDAQDESAS

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Crispr_ID: NZ_CP040438_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_5

1930659-1930821

Unclear

Consensus_repeat	Method
GCGGGTTGACCTCTGCCTGCTGGTGGTGGGTGCGCACCGTTGGTGCGCACTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040438_5

>merge|NZ_CP040438|5|1930659-1930821|CRISPRCasFinder
GCGGGTTGACCTCTGCCTGCTGGTGGTGGGTGCGCACCGTTGGTGCGCACTTGCAGTTGCCTGGAGGCCAGGGAAGCCACGCATGGCGTGGCTCTACTGCCTCTCCCCTAGGCGGGTTGACCTCTGCCTGCTGGTGGTGGGTGCGCACCGTTGGTGCGCACTT

>NZ_CP040438|5|5|1930659-1930821|CRISPRCasFinder
GCGGGTTGACCTCTGCCTGCTGGTGGTGGGTGCGCACCGTTGGTGCGCACTT	GCAGTTGCCTGGAGGCCAGGGAAGCCACGCATGGCGTGGCTCTACTGCCTCTCCCCTAG
GCGGGTTGACCTCTGCCTGCTGGTGGTGGGTGCGCACCGTTGGTGCGCACTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_005409257.1\|1933921_1934266_+\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|235518
NZ_CP040438.1\|WP_154263241.1\|1924221_1927062_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NZ_CP040438.1\|WP_154263239.1\|1923455_1924079_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|183566
NZ_CP040438.1\|WP_049447613.1\|1937875_1939135_+\|trans-2-enoyl-CoA-reductase-family-protein	unknown	unknown	gnl\|CDD\|237460
NZ_CP040438.1\|WP_005409254.1\|1927892_1929389_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|99735
NZ_CP040438.1\|WP_154264940.1\|1931359_1932460_-\|DUF3396-domain-containing-protein	unknown	unknown	gnl\|CDD\|371775
NZ_CP040438.1\|WP_154263247.1\|1934327_1936193_+\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NZ_CP040438.1\|WP_005409247.1\|1919787_1919982_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154263245.1\|1932656_1933787_+\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
NZ_CP040438.1\|WP_154263252.1\|1942585_1943134_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377782
NZ_CP040438.1\|WP_154263249.1\|1939243_1941313_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|376350
NZ_CP040438.1\|WP_110712004.1\|1936208_1937189_+\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NZ_CP040438.1\|WP_032128301.1\|1927081_1927675_-\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|129813
NZ_CP040438.1\|WP_154263236.1\|1921817_1922414_-\|DUF1949-domain-containing-protein	unknown	unknown	gnl\|CDD\|224653
NZ_CP040438.1\|WP_154263238.1\|1922454_1923459_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237865
NZ_CP040438.1\|WP_154263232.1\|1917451_1918360_+\|pyridoxal-kinase	unknown	unknown	gnl\|CDD\|238578
NZ_CP040438.1\|WP_154263233.1\|1918356_1919481_+\|prephenate-dehydrogenase	unknown	unknown	gnl\|CDD\|181561
NZ_CP040438.1\|WP_154263234.1\|1920052_1921825_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|131259
NZ_CP040438.1\|WP_154263244.1\|1930938_1931346_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154263250.1\|1941404_1942589_-\|aminoacetone-oxidase-family-FAD-binding-enzyme	unknown	unknown	gnl\|CDD\|224992

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_005409257.1\|1933921_1934266_+\|preprotein-translocase-subunit-YajC	gnl\|CDD\|235518	PRK05585, yajC, preprotein translocase subunit YajC; Validated.	1.17079e-48
NZ_CP040438.1\|WP_154263241.1\|1924221_1927062_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	1.73096e-94
NZ_CP040438.1\|WP_154263239.1\|1923455_1924079_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|183566	PRK12513, PRK12513, RNA polymerase sigma factor; Provisional.	1.31336e-82
NZ_CP040438.1\|WP_049447613.1\|1937875_1939135_+\|trans-2-enoyl-CoA-reductase-family-protein	gnl\|CDD\|237460	PRK13656, PRK13656, enoyl-[acyl-carrier-protein] reductase FabV.	0
NZ_CP040438.1\|WP_005409254.1\|1927892_1929389_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|99735	cd00610, OAT_like, Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, alanine-glyoxylate aminotransferase, dialkylglycine decarboxylase, 4-aminobutyrate aminotransferase, beta-alanine-pyruvate aminotransferase, adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and glutamate-1-semialdehyde 2,1-aminomutase. All the enzymes belonging to this family act on basic amino acids and their derivatives are involved in transamination or decarboxylation.	2.0556e-38
NZ_CP040438.1\|WP_154263247.1\|1934327_1936193_+\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	0
NZ_CP040438.1\|WP_154263245.1\|1932656_1933787_+\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	0
NZ_CP040438.1\|WP_154263252.1\|1942585_1943134_-\|hypothetical-protein	gnl\|CDD\|377782	pfam07152, YaeQ, YaeQ protein. This family consists of several hypothetical bacterial proteins of around 180 residues in length which are often known as YaeQ. YaeQ is homologous to RfaH, a specialized transcription elongation protein. YaeQ is known to compensate for loss of RfaH function.	5.75e-94
NZ_CP040438.1\|WP_154263249.1\|1939243_1941313_-\|EAL-domain-containing-protein	gnl\|CDD\|376350	pfam00563, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.	1.1472e-57
NZ_CP040438.1\|WP_110712004.1\|1936208_1937189_+\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	3.15773e-111
NZ_CP040438.1\|WP_032128301.1\|1927081_1927675_-\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|129813	TIGR00730, LOG_family_protein_YJL055W, TIGR00730 family protein. This model represents one branch of a subfamily of proteins of unknown function. Both PSI-BLAST and weak hits by this model show a low level of similarity to and suggest an evolutionary relationship of the subfamily to the DprA/Smf family of DNA-processing proteins involved in chromosomal transformation with foreign DNA. Both Aquifex aeolicus and Mycobacterium leprae have one member in each of two branches of this subfamily, suggesting that the branches may have distinct functions. [Hypothetical proteins, Conserved].	5.53764e-54
NZ_CP040438.1\|WP_154263236.1\|1921817_1922414_-\|DUF1949-domain-containing-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	3.69859e-60
NZ_CP040438.1\|WP_154263238.1\|1922454_1923459_-\|hypothetical-protein	gnl\|CDD\|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	1.35199e-08
NZ_CP040438.1\|WP_154263232.1\|1917451_1918360_+\|pyridoxal-kinase	gnl\|CDD\|238578	cd01173, pyridoxal_pyridoxamine_kinase, Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and require its precursors in the form of vitamin B6 (pyridoxal, pyridoxine, and pyridoxamine) from their diet. Pyridoxal kinase encoding genes are also found in many other species including yeast and bacteria.	8.81075e-90
NZ_CP040438.1\|WP_154263233.1\|1918356_1919481_+\|prephenate-dehydrogenase	gnl\|CDD\|181561	PRK08818, PRK08818, prephenate dehydrogenase; Provisional.	0
NZ_CP040438.1\|WP_154263234.1\|1920052_1921825_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|131259	TIGR02204, system_ATPase_and_permease_component, ABC transporter, permease/ATP-binding protein. This protein is related to a Proteobacterial ATP transporter that exports lipid A and to eukaryotic P-glycoproteins.	0
NZ_CP040438.1\|WP_154264940.1\|1931359_1932460_-\|DUF3396-domain-containing-protein	gnl\|CDD\|371775	pfam11876, DUF3396, Protein of unknown function (DUF3396). This family of proteins are functionally uncharacterized. This protein is found in bacteria and viruses. Proteins in this family are typically between 302 to 382 amino acids in length.	1.40003e-51
NZ_CP040438.1\|WP_154263250.1\|1941404_1942589_-\|aminoacetone-oxidase-family-FAD-binding-enzyme	gnl\|CDD\|224992	COG2081, COG2081, Predicted flavoproteins [General function prediction only].	0

>NZ_CP040438.1|WP_005409254.1|1927892_1929389_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MSFIERLAPLRSQPGTRLTTGLDDATLTALSANHPQLIAAVDAAAEEFARVQADLGPLLAQDEQAQIDAMQDGFVNFYADDAVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPDAVLEAMARPQVMANIMTPSLSQQRFITALRAEIGHRRGGCPFARFMCLNSGSEAVGLAARIADVNAKLQTDPGARHAGAAIKRVVVKGSFHGRTDRPALYSDSSRKSYMQHLASYRGEDSVITVAPYDEAGLRKVFEDAARNQWFIEAVFLEPVMGEGDPGRSVPPSFYAVARELTRAHGSLLLLDSIQAGLRAHGVLSVVDYPGFEGLDPPDMETYSKALNAAQYPLSVLAVTEHAAQLYRKGIYGNTMTSNPRALDVACATLAQLTPQVRANIAERGAEAVRKLEQLKNELGGLITKVQGTGLLFSCELAPQFKCYGANSTEEWLRQHGINVIHGGENSLRFTPHFGMDSEELDLLVGMVGRALREGPRREQAAAA
>NZ_CP040438.1|WP_032128301.1|1927081_1927675_-|TIGR00730-family-Rossman-fold-protein
MKSICVYCGSNAGSKPAYTERALALGDRIARDGMRLVYGGGNVGLMGTVANAVLAAGGEVTGVIPRQLADWEVAHRGLTELEIVGSMHERKSRMFDLADGFVTLPGGFGTMEEIFEMLTWRQLGIGNKPCAFLDVEGFYAPLIGMIDRMVEERFLHPDQRQDLWYGSDIEEMLEWMKNYKPAQASKWIDEKRRAALR
>NZ_CP040438.1|WP_154263241.1|1924221_1927062_+|EAL-domain-containing-protein
MSTHAEPAEVPLHEAVLSTALVRALHALLPETAVVRVGWDDPQLGRGQGAWPMAATGDDAAAPGVGDGQHGWEHDGARLLLSVEGAVPSPAWWGVARQAMELALQRGRQAGQIKALEEAERLQQALFQIADLAGADLEMAEMLRHVHGVLGTLMYAENCYIVEYDDVRDQIRFLYFADQVDDFVADPTQSHDASEMPRSLTVALLRHGKPLSGPSRELLAQVMEQEHDPQRGPESLDWLGVPMLRDGRVCGAIVVQSYEQAARYGEAERALLGFVAQHVQTAMDRRQAQVRLEQQVARRTQELQRANHSLQDEVAERRRAEQLQTALYNIAEMAMSADSLAQFYGQVHGVVGRLLDARNFYIALVNPAGNGLDFVYSVDEHNASRAPRPFSRGLTEYVVRNRRPLLASRAQIDALLASGEVRESGARSHCWLGVPLLRDDEVVGAIVVQSYSENSIFSVHDQRLLTFVAQNIGTGLARQRDQQRLRSAHAELEKRVEERTRELAEVNEKLLGQIGERLRAEQRLTHQAMHDALTGLPNRLHLLDRLQDALALAKREGGPVFAVLFLDLDRFKLVNDSIGHAAGDRMLVEVAKRIVSMAGTGDVVARLGGDEFAVLLQCPQGLAQALDFGQRLLLALQESMWIAGRELFPSGSLGIALWNPRYRTGEELLRDADAAMYRAKAQGHDRCAIFDEDMREQAMRSLDLEADLRRAINNRDFVPFYQPIVRLSDGEVVGHEALLRWQHERRGLLLPGAFLELGEESGLIEQVDWLIYEQVIAGLAEGGHTYVSVNVSPRHFRSAGFSGRLFGLLDACGADPCRLRLEITEVALLDDGPHTLRILQGLRERGIQVQLDDFGTGFSALSYLHRFPISTLKIDQSFIAGLHGPEVQSTRALVEGVLSLARTLGIETIGEGIETEAQRQTLRELGCDYGQGYLLGRPAPWSCAAV
>NZ_CP040438.1|WP_154263239.1|1923455_1924079_-|RNA-polymerase-sigma-factor
MTLALPAPATGYAPSPAGLTLYAVEASALPTDEALMLAWAGGDLRAFESLYARHRKRLFGFLLRQLRDNALAEEIFQDVWQRVISARAGWQPDAAFSTWLFRIAHNRLNDHWRAARHRPAAPADADLRLAAIEDGQTPEGELSEFEQRRRIQLAMEQLPPEQREVLQLRLDQELSLEEIGQITGVGRETVKSRLRYAMDKLRAGLNA
>NZ_CP040438.1|WP_154263238.1|1922454_1923459_-|hypothetical-protein
MNRDEPLTAEERELARLLGRRAEQAPPAALDDAILAAARTAVDAPAADAVASSEAPRTQRTRPRWPAVFGIAASMVFAIGIAWQLRPEPPPVPAGEAAVAAATAAAEDVAAADQAAERSAADSAVAAAEPATAPAVPEAAPVAAAPAPAIARAPRPAPTATAEAPAQAARSMAADAAADTSFAALPPAPAAAPAAAPPAPPAPTAYSAPAPLMAPVVASGSLKARSAGTPESNSVQAEQAPALDRVEITSVKREAPSRSAPGIMRRGSDAGLSADAVQAEVEADARLPRRQWLQKIRARRDDGQRDLARASLERYMQQYPEARLPRDLRPLLDD
>NZ_CP040438.1|WP_154263236.1|1921817_1922414_-|DUF1949-domain-containing-protein
MPDTLAQPVSHTLEVKHSRFIAHATPIDGAAAAMAFLQQVAVADATHNCWAYRHGQDYRSSDDGEPAGTAGRPILAAIDGQGFDRVMVVVTRWFGGIKLGAGGLVRAYGGAAAECLRTAPRLPLVAMARLQLLAGFEDLGTLHATLPAFGAEKRDEQFDANGVCLRIELPADQVDALKIRLRDATRDRIRIEDDDQDD
>NZ_CP040438.1|WP_154263234.1|1920052_1921825_-|ATP-binding-cassette-domain-containing-protein
MTDKDDAPASTPPLRRLGSLRTLWPFVRRHSGLFTAWLLALAVSSAATLSLPPAVKQMIDHGFSSGGQINRAFALLMLVAVVMALGTAARFYFVSLLGEKVVADLRSQLYAHLIQLGAGFHDRSRSGELVSRLTADTELLRSVVGSTMSVALRSTVTVIGSLAMLFVTSPRLAAWSLLGIPLAVLPIIIGARKLRTVARNSQDRIADANSLASETLGAVRTVQAHAREPYERGRFDKALGDAIGAARRRIGAQSLVTASAILLVFGAIVGVLWLGAHDVIDGRLSAGTLGQFVLYALIGGGSVGALAEVWNELQRAAGGMGRIGELLQEDIEIRAPAQPHALPQPLRGEIQFNDVVFHYPQRPDQAALDHFNLHVRPGETVALVGPSGAGKSTVLSMLLRFHDPASGRIDVDGIDVRQVDPAELRAQLALVPQQPTLFAASARDNIRYGRLQASDADVEDAARAAEADGFLRALPQGYDSELGERGARLSGGQQQRVAIARALLKDAPILLLDEATSALDAQSEHSVQQALERLMAGRTTLVIAHRLATVLKADRIVVMDQGRIVAEGTHAQLLAEGGLYAELARLQFID
>NZ_CP040438.1|WP_005409247.1|1919787_1919982_-|hypothetical-protein
MSFRQFPAVDSNGESHIIIEFKPEANGSGHHSEATPRYELDDGRPLVRDGREFTTSGGELRLTI
>NZ_CP040438.1|WP_154263233.1|1918356_1919481_+|prephenate-dehydrogenase
MSGLLERTPRTVGIVGSAGAYGRWLSRFFQQHMQLQAIGHDPADPDSHTPEQLLAQADVLVFSAPIRHTPALIAEYVRQSAGREQDRLWLDVTSVKEAPVQAMLASQAEVVGLHPMTAPPKAPTLKGRVMVVCEARLRDWQPWVDSLCTALQAECVRATPQHHDQMMALVQAMVHATHLAQAGVLRQYQPQLGDLAAMMPYRSASFELDTAIISRILSLNPAIYEDIQFGNPYVAPMLERLVGQLQALQAQIGQGDDHARGDFREQLLSANRSAFGEQALADGNYTFERVGYLLADLTERNALSVHLPEDRPGSLRELLNVFEQHRISLASIHSSRTPGGEVHFRIGFVAGSDAAAITRAAAEVDASGIGRVLG
>NZ_CP040438.1|WP_154263232.1|1917451_1918360_+|pyridoxal-kinase
MSESLDNHLVHGRRQRPDGPSPIDVISVQSQLVYGHAGNSAAVPPMRTLGVRVAEIPTVLLSNAPFYDTTRGRVLPADWFADLLLGTHERGLPQRAKMLVSGYFGSTANGAAFADWLDNILPACPQLRYCLDPVMGDTHTGPYVEPGLEAIFAERLLPHAWLVTPNAFELNRLTGMPALAEADAIAAARTLLDRGPHWVIAHSVGGNPGELVTLAVGREETWRWTSPLLPVDVAGTGDVLMSLVVSFLLRGESMQQAISRAIAGTHAALEATLDNGFEEFDVIAAAPAALAEGTRFRAERVA
>NZ_CP040438.1|WP_154263244.1|1930938_1931346_-|hypothetical-protein
MSNDRKNLERILGGRIEQRADRTAPGINSVTGVEFIYYEDDGIRSASSQFNALLDSAGEIAASSGGIVSDSCRITLPNGQCFLALSFHGDLDGWRKAVEAGARNLGLRLARIEVDHLMISDGQSVSLSECKVDLC
>NZ_CP040438.1|WP_154264940.1|1931359_1932460_-|DUF3396-domain-containing-protein
MQGCPEALGAQQFPGDLLLPGGPRNYVGAVICLRLTLYFKDAHTAATRRHLCLCFDAFCELAGDALSWLWREKPKRGMPKQRVKNSKSLRDMIENMSEDDHLSFCYTSGAMAQDAGAWKFLIFGARGWEARIGSDMSVLELSVPISCLPTQREDFVELAAKCARWLSAEHGHAGYAVNMSEVRRERNEPVEAILAQRYPGLDAGCAPFLANQPQLAHLKIKTVSWLTLLDHARLEAAGGLDQLRSALPEQHFSLHDYGHGVMIQAGPRPLALVDAGDPRPPAYVLLDHQLRGIRPASVGSLHFNPKSAEPRLVGRLADQWMGRFEVDASEISTHEERLAQQHPLSDGDLQDETPFVNQSIAREMPQ
>NZ_CP040438.1|WP_154263245.1|1932656_1933787_+|tRNA-guanosine(34)-transglycosylase-Tgt
MSRLQFQLQTRDGRARRGRLTFPRGTVETPAFMPVGTYGSVKGILPDQVRALGAEIILGNTFHLYLRPGLDIIADHGGLHGFCRWDGPILTDSGGFQVFSLAHRRKITEQGVTFASPTDGARVFLGPEESMKIQKVLDSDVVMIFDECTPYPATEDVARRSMELSLRWAQRSRNAHDELGNDAALFGIVQGGVHTDLRSRSAEALQAIGFDGYAIGGLAVGEPEHERNAMLDHLDPELPADRPRYLMGVGRPEDLVEGVARGVDMFDCVMPTRNARNGHYFTSFGTVRIRNSQYARDMDPIEPGCGCVACTGGYTRSYLRHLDRCNEMLAPMLGTLHNLFYYEKLMADVRAAIEAGTFLAFRESFYAARGAVAPPL
>NZ_CP040438.1|WP_005409257.1|1933921_1934266_+|preprotein-translocase-subunit-YajC
MNLLAFLIPAAHAQAAGGQPQGMGLTTLLFPVILIAIMYFLMIRPQMKRQKEHKAMLEKIKRGDEVLTNGGIAGIVTDIGDNFITIEVADNVRIRVQKGAVGNVLPAGTLKSAQ
>NZ_CP040438.1|WP_154263247.1|1934327_1936193_+|protein-translocase-subunit-SecD
MLEFPRWKYVVILIVLALSALYALPNIYQKDPALQITANRGGQIDDALRDRVLADLKKAGVATVGAEKEGESLIVRLPDLKAQSAASDALRDTVGEKYTVALNLASTVPDWLANLGGRPMVLGLDLQGGVHFVLQVDQKAALDKRLDAYTEDVRSTLRDARIAYQSVERRADNSIVANLSPSAGDDAAQRARTALVKAQPTLGYDVSGNRITVTVPETEITQIANGAIEQNINTLRNRVNQLGVAEPIIQRQGADRVVVQLPGVQDTAEAKRMIGATATLEYRAVVDGNPTSVADKIASGRIPPEAKIYQRRDGGGPVLLNKRVIVTGDQMVGAQAVTDSNSGSPAVSVTLNNVGGQRMFDFTSANVNKPMAVVYTERVPTVTVVDGQEVRGFKVNEEVISVANINGVFGKNFQTTGLQKKEAEDLAKLLKSGSLAAPMDFVEERVVGPSLGAENVKNGMRAVVFAFLFTLVFFSVYYRMFGVITSIAMLFNLLIVVAVMSLFGATMTLPGFAGLALSVGLSVDANVLINERIREELRAGVPGKTAIVTGYERASGTILDANLTGLIVGVALFAFGTGPLKGFALTMIIGIFASMFTAITVSRALATLIYGRRKKLQNVAI
>NZ_CP040438.1|WP_110712004.1|1936208_1937189_+|protein-translocase-subunit-SecF
MKLFPLHILPNDTKIDFMRWRHVAMVVTVIVFLASIAIIGVKGFNYALDFTGGTLIEARFDKAVDVEQVRTKLEQNGFEGAQVQSVGGNTDLLIRLAPHGEHAAGTGDAAHEDKATAAAVVKALSTADNQATVLRNEFVGPQIGKDLAMNGLYATIFMLAGFLIYIAVRFEWKFAVTASIVAMFDLIVTVAYVSLLGREFDLTVLAGLLSVMGFAINDLIVVFDRVRENFRSLRVDSMEVLNRSINQTLSRTVITAVMFFLSALALYMYGGSSMEGLAETHMIGAVIVVLSSILVAVPMLTIGFLRVSKQDLLPKAKDVEALARRP
>NZ_CP040438.1|WP_049447613.1|1937875_1939135_+|trans-2-enoyl-CoA-reductase-family-protein
MVIKPRVRGFICVTTHPTGCEAAVKQQIDYIRARPPIQNGPKRVLVIGASTGYGLAARITAAFGSGAATLGIFFERPGSETKPGTAGWYNSAAFHKYADEAGLYAKSINGDAFSDEVKARTIEMIKADLGQVDQVVYSLAAPRRKHPKTGEIISSTLKPIGEPITLRGLDTDKEVLTETHLQPATPEEIAGTVAVMGGEDWQMWIDALADAGVLANGCTTTAFTYVGEEITQAIYWNGSIGAAKKDLDTKVLGLREKLAKIGGDARVSVLKAVVTQASSAIPTMPLYLSLLFKVMKEKGTHEGCIEQLDVLYDILYGGKADGVAIDRLRHDLVDGDGHTVALVDDEGRLRADYKEMAADVQGKVVALWPQVTNENLYEISDLAGYKADFLRLFGFGVEGVDYEADVNPDVKIENLVDMT
>NZ_CP040438.1|WP_154263249.1|1939243_1941313_-|EAL-domain-containing-protein
MQNANDITIRLLIVDDSGENAEAIVSTLRNSGIAVRPWRPQDAAELAQVLSSQAIDLVLASPSQGIPLPLVAQHIAASGKDIPLVLLAERIDEDELVQASSHGIRALALRQRPEHLLAVVRDQWVDLQARRGLRRIEAQMRETERRCDALIASSRDPIAYVHEGMHIRANDAYLEMFGYEHFDDIEGISLLDMVAAQHVEGFKQLLKGLSRGEAPPPQYQLDARHEDGSAFPATMEFTAATYEGESCLQVVLRRRMEFDPELAREVEDLRQRDQVTGLLNRPTFMLQLESAVAQAGRSEGQFGLLLIEPDHYARLLPDIGLASADTLIGALAALLVEVVGEDAQLARFGEHNFAVLQAGPYAQTVALAERIREAYAAHVFSIGARSATVTVSIGGVQVGEKIASIGQVLARASECTQAAAELGNTCRIFDPAAADRVEEERVLRWVARIREALAGDGFQLHYQPVLNLQGESLELYEAYLRLEHNGELLSPTAFLGIAEEHGLLADINRWVVSRAIAVLGQRAREGHATQMLVKVTPESFDDPQMIATLRRELQAQGVPGERLWLHAPEAKVFTHLRSAQQFLAEVAPLGCRIGLEQFGSGLDSFQLLAHFQPQFLKLDRGFTSDLAATRENIDRISQITARAQEAGIRTIAEFVSDANSMTLLFSAGVDYVQGDFVGPALPEMGFEFG
>NZ_CP040438.1|WP_154263250.1|1941404_1942589_-|aminoacetone-oxidase-family-FAD-binding-enzyme
MSTIRCDVVVIGAGAAGLMTAITAGQRGRQVQVIDHANKVGKKILMSGGGRCNFTNTGTTPANFLSANPHFCKSALARYTPWHFIELVSKHGIAYHEKELGQLFCDISSKQIVKMLVDECQAAGAQIRTECSVQRIEHGSDGFRVHTTHGLFHCASLVVATGGLSIPSMGATGFGYEVARQFGHQVLPTRAGLVPLTLSGKHQERLADLSGVALPIEARCNGKSFQNFMLLTHRGVSGPAILQISSFWQPGDALELDLLPGHDAGEWLRQMKRERPAAELRTVLGEVLPKRLAQRLCEHWLPDRPVRQLDEPVLRQAAQLLGAFPLVASGTEGYRTAEVTLGGVDTAEVSSSTMESKRVPGLHFVGEVLDVTGWLGGYNFQWAWASGHAAGGVV
>NZ_CP040438.1|WP_154263252.1|1942585_1943134_-|hypothetical-protein
MALTATIRKAELQISDMDRGYYATHNLTLAQHPSETDERLMVRLLAFALNAGDRLEFGRGLSTDDEPDLWEHDYTGDILQWIDLGHPDESRIRKASNRSRQVQVINYGGNASEIWWGKQGKGLARFDNLSVVDLNGEFVERWGQQIQRAMRWSVLIQDGEVQLLNDQMQLDVIPNWRKRAKA

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Crispr_ID: NZ_CP040438_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_6

2186562-2186661

Orphan

Consensus_repeat	Method
GGTAGGTGTCGACCTTGGTCGACAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040438_6

>merge|NZ_CP040438|6|2186562-2186661|CRISPRCasFinder
GGTAGGTGTCGACCTTGGTCGACACACGGACCGCCAACCAAGGTTGGCGGCAACCGGGCAGCGGGCAGCGGACCTGGTAGGTGTCGACCTTGGTCGACAC

>NZ_CP040438|6|6|2186562-2186661|CRISPRCasFinder
GGTAGGTGTCGACCTTGGTCGACAC	ACGGACCGCCAACCAAGGTTGGCGGCAACCGGGCAGCGGGCAGCGGACCT
GGTAGGTGTCGACCTTGGTCGACAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_154263412.1\|2171722_2172199_+\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NZ_CP040438.1\|WP_049429885.1\|2195363_2197046_-\|choline-dehydrogenase	unknown	unknown	gnl\|CDD\|235000
NZ_CP040438.1\|WP_154263421.1\|2193464_2195141_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|181546
NZ_CP040438.1\|WP_006364528.1\|2188520_2189660_+\|two-component-system-response-regulator	unknown	unknown	gnl\|CDD\|225971
NZ_CP040438.1\|WP_154263418.1\|2184889_2186530_+\|acetolactate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236239
NZ_CP040438.1\|WP_012480080.1\|2192394_2193264_-\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|236338
NZ_CP040438.1\|WP_154263423.1\|2198659_2199250_-\|transcriptional-regulator-BetI	unknown	unknown	gnl\|CDD\|179115
NZ_CP040438.1\|WP_154263416.1\|2179552_2180455_+\|LytTR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197918
NZ_CP040438.1\|WP_154263420.1\|2189661_2192382_+\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NZ_CP040438.1\|WP_154263425.1\|2201086_2201542_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154263424.1\|2199420_2200971_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP040438.1\|WP_154263413.1\|2173281_2175039_+\|single-stranded-DNA-specific-exonuclease-RecJ	unknown	unknown	gnl\|CDD\|182944
NZ_CP040438.1\|WP_088025848.1\|2172203_2173121_+\|phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|226706
NZ_CP040438.1\|WP_154263414.1\|2175184_2178094_+\|DUF2135-domain-containing-protein	unknown	unknown	gnl\|CDD\|378008
NZ_CP040438.1\|WP_088025854.1\|2181876_2182659_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NZ_CP040438.1\|WP_154263419.1\|2186845_2188315_+\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NZ_CP040438.1\|WP_154263415.1\|2178208_2179417_-\|acyltransferase	unknown	unknown	gnl\|CDD\|235167
NZ_CP040438.1\|WP_154263417.1\|2183440_2184826_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143418
NZ_CP040438.1\|WP_154263422.1\|2197147_2198620_-\|betaine-aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|183918
NZ_CP040438.1\|WP_012510936.1\|2180525_2181651_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|136970

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_154263412.1\|2171722_2172199_+\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	3.78037e-81
NZ_CP040438.1\|WP_049429885.1\|2195363_2197046_-\|choline-dehydrogenase	gnl\|CDD\|235000	PRK02106, PRK02106, choline dehydrogenase; Validated.	0
NZ_CP040438.1\|WP_154263421.1\|2193464_2195141_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|181546	PRK08751, PRK08751, long-chain fatty acid--CoA ligase.	0
NZ_CP040438.1\|WP_006364528.1\|2188520_2189660_+\|two-component-system-response-regulator	gnl\|CDD\|225971	COG3437, COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms].	1.74736e-134
NZ_CP040438.1\|WP_154263418.1\|2184889_2186530_+\|acetolactate-synthase-large-subunit	gnl\|CDD\|236239	PRK08322, PRK08322, acetolactate synthase large subunit.	0
NZ_CP040438.1\|WP_012480080.1\|2192394_2193264_-\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|236338	PRK08788, PRK08788, enoyl-CoA hydratase; Validated.	1.08859e-156
NZ_CP040438.1\|WP_154263423.1\|2198659_2199250_-\|transcriptional-regulator-BetI	gnl\|CDD\|179115	PRK00767, PRK00767, transcriptional regulator BetI; Validated.	4.45528e-105
NZ_CP040438.1\|WP_154263416.1\|2179552_2180455_+\|LytTR-family-transcriptional-regulator	gnl\|CDD\|197918	smart00850, LytTR, LytTr DNA-binding domain. This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.	1.26681e-29
NZ_CP040438.1\|WP_154263420.1\|2189661_2192382_+\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	8.13954e-84
NZ_CP040438.1\|WP_154263424.1\|2199420_2200971_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NZ_CP040438.1\|WP_154263413.1\|2173281_2175039_+\|single-stranded-DNA-specific-exonuclease-RecJ	gnl\|CDD\|182944	PRK11070, PRK11070, single-stranded-DNA-specific exonuclease RecJ.	0
NZ_CP040438.1\|WP_088025848.1\|2172203_2173121_+\|phosphoglycerate-mutase	gnl\|CDD\|226706	COG4255, COG4255, Uncharacterized protein conserved in bacteria [Function unknown].	1.72764e-61
NZ_CP040438.1\|WP_154263414.1\|2175184_2178094_+\|DUF2135-domain-containing-protein	gnl\|CDD\|378008	pfam08487, VIT, Vault protein inter-alpha-trypsin domain. Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumor metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.	6.63197e-30
NZ_CP040438.1\|WP_088025854.1\|2181876_2182659_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	6.95959e-45
NZ_CP040438.1\|WP_154263419.1\|2186845_2188315_+\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NZ_CP040438.1\|WP_154263415.1\|2178208_2179417_-\|acyltransferase	gnl\|CDD\|235167	PRK03854, opgC, glucans biosynthesis protein MdoC.	3.46961e-16
NZ_CP040438.1\|WP_154263417.1\|2183440_2184826_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143418	cd07100, ALDH_SSADH1_GabD1, Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like. Succinate-semialdehyde dehydrogenase 1 (SSADH1, GabD1, EC=1.2.1.16) catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde (SSA) to succinate. SSADH activity in Mycobacterium tuberculosis (Mtb) is encoded by both gabD1 (Rv0234c) and gabD2 (Rv1731). The Mtb GabD1 SSADH1 reportedly is an enzyme of the gamma-aminobutyrate shunt, which forms a functional link between two TCA half-cycles by converting alpha-ketoglutarate to succinate.	0
NZ_CP040438.1\|WP_154263422.1\|2197147_2198620_-\|betaine-aldehyde-dehydrogenase	gnl\|CDD\|183918	PRK13252, PRK13252, betaine aldehyde dehydrogenase; Provisional.	0
NZ_CP040438.1\|WP_012510936.1\|2180525_2181651_+\|peptide-chain-release-factor-2	gnl\|CDD\|136970	PRK08787, PRK08787, peptide chain release factor 2; Provisional.	0

>NZ_CP040438.1|WP_154263418.1|2184889_2186530_+|acetolactate-synthase-large-subunit
MSKGSDLLVAALENEGVERIFGIPGEENLDVVESLRHSSIELVITRHEQAAVFMAATYGRLTGKPGVCLATLGPGALNFTTGAAYALLGAWPVIMITGQKGIVASKQARFQIVDIVSTMKPLTKQARQIVSARTIPTIVREAFRTALEERPGPVLLELPEDIAADEVGDVALIPPHAVDRPIASPEALDRAAEIIRNAKRPLLMIASAASRPQSSEALSAFVLRAGIPFFTTQMGKGAVAGGSGLYMGTAALTERDYVHMAIDQADVIVTIGHEVTEKPPFVMRPGGPTVIHIGYSQAAVEQVYFPQVEVIGDIGRSLTQLADRIEGAVPNADALLPLRATILEHLADRAEEAGFTPQRLVHDVRQVMPPDGIVALDNGMYKIWFARNYRTQVANTLLLDNALATMGAGLPSAIMASILYPQRRVLAVCGDGGFMMNSQELETARRLGLNLVVLILNDGAYGMIRWKQAVDGFPDYGMTFSNPDFVKYAQAYGCKGHEVTAIEQFIPTLEAAFNEGGVHLVSVPIDYSENQRVLVDELRQAFPGNG
>NZ_CP040438.1|WP_154263417.1|2183440_2184826_+|aldehyde-dehydrogenase-family-protein
MSAAPSTAISRDPATGQQIASHPFATDAELETILDRGQAGFAAWSAKSLEQRADVLRAMAAVLRRDREKLAALATAEMGKVQAESLAEIEKCAVLCDWYADHGAQFLRDEPTRVPDDKAYVSYLPLGVVLGIMPWNFPYWQVMRAAVPILMGGNGFLLKPAENIVGTAQLLDAAWRDAGLPEGTFIAANISRDGTSRAIADDRIAAVTLTGSVAAGRSIAAQAGQALKKVVLELGGSDPFIVLADADLDAAVEAAVASRFQNTGQVCIAGKRIIVEDAVYDRFVAQFCQKVQALTIGDGREAGNRIGPMARQDLLEQLDAQVRASVDAGAKLLVGGHQLDRPGAFYAPTVLADVEPGMQAFDTETFGPVASISRARDADHAVELANQSEFGLSGNLWTGDRARAMQLARRMQTGGVFVNGFSASDPRVPIGGVKKSGFGRELSHFGIREFVNAQTVWFDKR
>NZ_CP040438.1|WP_088025854.1|2181876_2182659_+|helix-turn-helix-domain-containing-protein
MMRSESERKELGGFLKACRARVDPATLGLPAGRRRTPGLKREEVALAIGVSVSWYTWIEQGREVRASPEVLERLAQVLRMSDDERAYAFALSGYGVPLESPDESVTDGLRQLVEAMQPIPAYVRNTRYDILAWNPAIAELFVDYSQLAPHERNTLRLMFLYPPYRTLILNWEEMTRGLLAGFRAAMAQAPDKAPFLALAEDIAAHSEEFRQWWPEHDVRRFDEGAKKLNHPTRGLLDLQYVALVPESRHDLSLVTYLPRR
>NZ_CP040438.1|WP_012510936.1|2180525_2181651_+|peptide-chain-release-factor-2
MIELNPVRQRITDLTDRVLSLRGYLDYDAKKERLEEVTRELESPDVWNNAEYAQNLGRERSSLEKTVGGIASVLDGLADATELLELAESEQDEDTALAVVADLDKHQAHVEKLEFQRMFSGEMDNAAAFVDIQAGAGGTEAQDWAEILLRMYLRWCESRGWKTELMEVSGGDVAGIKSATLRVEGDYAYGWLKTETGVHRLVRKSPFDSDNRRHTSFTSVFVSPEIDDNIDITINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNIVVACQTGRSQHQNRDNAMKMLAAKLYELEIQKRNAEKDAVEATKSDIGWGSQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEASLKAGLAVGSKRVDA
>NZ_CP040438.1|WP_154263416.1|2179552_2180455_+|LytTR-family-transcriptional-regulator
MGNNGSMENGDSAALTAPVAERTRRPGLAVAFWSLLFLGTAAGNVLAQWMRALRDAQPFSAGTISIEEFSSALASLGLLALLHAAARRWPLHADTWRRRIGFYVLGGVAWWLLHVSAMVLLRQMAFAFIGQHYIYGDWPAQWFYEFFKDVQTYSLLVIAVHAVAWFGRQRQGEAHLLASPDVGPPVEPVERPQHFLVRKLGKEFLVATADVEYAQAAGNYVNLRVRGHDYPLRITMAVLEQRLDPGEFLRPHRSWLIHRGQLRSIEPLDGGEALLHMADGAKVPCSRRQLPLLRQALGAG
>NZ_CP040438.1|WP_154263415.1|2178208_2179417_-|acyltransferase
MHRRHDLDTLRIAAFALLILYHAAMAYVAGWDFHLKSTYTSEWLQWPMIALNRWRMPLLFAISGIALGLSLPDHGRLQHMLRRSWRLLLPLVFGIVAVVSLQAYCEALDKGDVAPGLGHFLRRYWQFRPWPGAHFSGAAYGFTWNHLWYLAYLLPYTVLAVALASLLRPLCRALPRWQPSDRLLGTLLLVPPVAWLAWSLLVLMPRWPPTHALLDDVYVHAESLSLFLGGFLAARWQRGWDLLVRGRRVTLALAVLGLCLELGIRALARLPHVGDLDAWVLALPWAQTERVGRALYTWCMLLTLFGWARVLLDRPWPGRNYCREAVFSWYILHQTVLIVLLYALRPLQLGPWLEPTLLVAGTIGGCLLIHELLIRRVRWLRPLFGLRADPPASPIARAATAR
>NZ_CP040438.1|WP_154263414.1|2175184_2178094_+|DUF2135-domain-containing-protein
MVFARCCTVLLLALAAWPAGAQSPPISRPQATTPLLIAPAAEQPVQLQRARIEGEVQAGIAQTRITLEFHNPNRRVLEGELQFPLADGQQISGFALDINGELRDAVPVPKDRGRQVFEEIARRGVDPGLLEQTAGNQFRLRIYPLPAGGSRRVQLVIREPLALAGQGWQWTLPLQFAAGAASVELKLQAPEAATAGTAPFRINAGQLHWQGKGAQLPNQLQWSLPAARQAQVQVAPWQDGHYLLAQLPVSPSSTPRTLPSEIGLLWDGSGSAGQRDRTREFALLDRYFAALGDGTVALTVLRDRAEPVRRFRVRAGNWSELRAALQAVRPDGASALAQWQPQPSVKEYLLVSDGLLTYGPEALPALAPQQRLFAVSSAGARTDAVRLRGWSEAHGGRFVALGKDVGAAARELLSSPLDVQVDAGRGVQDVVIDRRSEAEGWLWLHARLAADGVPMRVRAGGGEWQALPATQKSDDGELLAGLWAQARLQQLGADRRGNREAMQLLSQQFGLVGPDTSLIVLETLDDYLRYAIRPSGKLRAEYDARFAVQVSDRAAADRRRLDEVAARWKERQQWWNRSWPKGAPPQLKGGALEVASAEYAMDSAPVAMLAAPAPAAPPAPAPMAAAAEQRMEASSARARRSASASNKALDVVALTGSVVAASAANNGELGIQLAAWQPDSAIARRLRQGPPSQLYDRYLAERDAHADSSAFFLDVADLLLEQGQRELALRVLSNLAEMDLDNRHLLRVLGYRLMQADAPALAVPVFEQVLAMGQEEPQSFRDLGLALAAAGKLQQALAPLYQVVVRPWDSRFDGIALIALDELTNLVARSTPQLDTTSIDPRLLQAMPLDLRVVLSWDADNSDMDLWVTDPNGERAYYGNRLTYQGGQMSQDFTGGYGPEQFSLRNAKPGKYKVEANYFGSRQQLVTGATTLMLRLTTHWGTAKQKDQMVTMRLKDRAETVLVGEFEVK
>NZ_CP040438.1|WP_154263413.1|2173281_2175039_+|single-stranded-DNA-specific-exonuclease-RecJ
MSLAADAVQPSSDTPTIRRRDAVAPGSWPEGTLPLLARLYASRGAGTPELALPKLGSLHAPELLTGIDDAVGLLVEAIANDKRILVVGDFDCDGATACAVGVRGLRMLGAQHVFHAVPNRMVHGYGLSPSLVEELVALQPDLLVTVDHGIACHAGVIAAKARGWQVLVTDHHLPGPQLPPADVIVDPNLDGDAFPSKSLAGVGVIFYVLMALRRQMREAGVFADGKGPDLTTLLDLVAVGTVADLVALDPNNRALVSAGLRRLRAGQGCVGLRALIEASGRDAARLTATDIGFALGPRLNAAGRLEDMALGIALLLTEDPRQAREIAQTLEQINSERRAVQQSMTDDAEQALTRVVLDMAGQRPVAACLFDADWHPGVVGLVASKMKDRLHRPVIAFAPAEPGADTLRGSARSIPGLHIRDALALVDARHPGLIERFGGHAMAAGLSMRLDRVDDFKTAFVSVVLEMLDPAALQQQVLSDGELAADELDHRHADALRLAGPWGQGFPEPLFDGHFEVANWRVLKERHLKLELRLPGVPGTINAIHFGGWHGNAPGRHVHLAYRLACDDYRGGSAIQLIVEHCLPA
>NZ_CP040438.1|WP_088025848.1|2172203_2173121_+|phosphoglycerate-mutase
MATATLLLPARSRFAAAALPDDVARALGRANASQFEAGERAQLQRHFTVAAPHWPVAALSRQRDAGDAAGACWLRADPACMVPDMHGARMMAYGETLRPTLADSLALLPVLQPLFADAGFVLDAPDPSRWYLRLPIDLALPDFDSPDEVLGDDLFSHLPEGEGGRRWRALMTEAQVLLHNHSWNQQRAAQGQQPINSLWFWGGGVMPVSVSTPHAQVRSRDALLQGLALAAGVAVDGEQAVDALVDLRQLRSLQQLGNDAIRPLLAALKRGELQRLVLDFEDGQQFQLDRGQRWQFWKKPRQLHD
>NZ_CP040438.1|WP_154263412.1|2171722_2172199_+|transcription-elongation-factor-GreA
MRAPITMKGAQKLRDELEHLKSVKRPKVIAAIAEAREHGDLKENAEYHAAREEQGFIEGRIKQLEGELSHAEIIDVSKLNAGSKVVFGASVTLADVETDEEKKYQIVGDLEADIKLGLIAISSPVARAMIGKLEGDSIVIDAPAGQREYEIVSVSYVD
>NZ_CP040438.1|WP_154263419.1|2186845_2188315_+|lysine--tRNA-ligase
MIAERREKLKTLRGQGIAYPNDFRREDFAGRLQEEFADAGQWTAEALEGNGRQVKMAGRLMAKRIMGKASFAQIQDESGRIQLFLQGTVLGDAYTAFKGWDVGDIIAVEGGLTRTKTGELSVKAESIRLLTKSLRPLPDKWHGLADVEQRYRQRYVDLIVTPESRAVFIKRSKIIRAMRAWLDNRDFLEVETPMMHYIPGGAAAKPFTTHHNALDLDLYLRVAPELYLKRLTVGGLERVYEINRNFRNEGVSTRHNPEFTMMELYEAYATYNEIMDLTEGVIRDVAQTVNGGTEVEWDGAKIDLGPAFRRWRMDEAVRHHNPEISAADCTDREALLRHCERLKIRVKPSYGWGKLLLEIFEATVEHTLIQPTFITDHPVEVSPLARANDNDPGYTDRFELFVNGKELANGFSELNDPEDQAQRFQAQVAAKEGGDDEAMHYDADYIRALEYGMAPTGGLGIGVDRLVMLLTGSSSIRDVLLFPYMRPEQ
>NZ_CP040438.1|WP_006364528.1|2188520_2189660_+|two-component-system-response-regulator
MQGASVRSGRVSSPADDPAWSRNQAEYALNIVIVDDQTSARTMLRHVIEDIAPELSVYDFGDPLTALAWCEAHPVDLLLLDYRMPEMDGLEFARRFRRLPKHRDIPVILITVVGDEPIRQAALEAGVIDFLVKPIRPRELRARCYNLLQLRQQTENVKQRALSLEQRLLASMHEVEERERETLSRLARAIEFRDAGTSAYLERMARVAGLIAEQLGLPEDDVRLIEMAAPLHDMGKIAIPDAVLLKQGKLNDEELAIMRRHPRIGHELLSGSQNRFIQVGALIALRHHERYDGSGYPDGLVGEAIPLEARIVAVADVFDALISPRPYKEAWTMEATLAYLYAQRGRLFDPRCVDALMRGHQQLMDICAQHSTASTRPGG
>NZ_CP040438.1|WP_154263420.1|2189661_2192382_+|response-regulator
MQDLFARVKRRLAQRPDSEHGQAIVRVVLISLILVYVLLSGARQHRLDQYQGVLATVLTGLGLSLLLFGWLLWKPERSDPRRVAGMLADYGLIAVGMIQMGEPLAWVYAVVMWVTVGNGLRFGPRYLAAAIVLAMVSFGTTVLLTPYWQANLGLAISLWLGLLAVPLCCSSLLRRRMRHPNMDTTPAAAHNRSLLARFRQRLSGREDSEHAQNLIRIVITALFISYLGWRSLSGGGEALTATWLILAFELTISACLLAAILVNPGVSHVRRVIGMLTDYTCMAWIMTIQGEPAAPLYAVMLWVTIGNGMRYGSTYLRVATAMGCLAFLCTVMLSPYWRGHDYLGWGLLLGLGAIPLYFDSLLHALTRAVAEARQANEAKSRFLANMSHEFRTPLNGLAGMTEVLATTRLDDEQRECLNTIQASTRSLLALVEEVLDISAIEAGKVRVEWHEFALADVLQAINLILTPQTRSKSLDYRVQVDDNVPPRLLGDAGHLQQILLNLMGNAVKFTESGYVHLRVSSPDALGSDRVRLRFEIVDTGIGVPVALRGRLFNAFEQGDVGLARRHEGTGLGTAIAKGLVESMGGQVGYAPNSPRGSVFWVEITLDVAETSSAPAVPSEVAEAGNVIAFSNPFLRHRARVRSLRVLVADDHEANRMVLQRLLEKAGHKVTCVNGGAEVLDALEQASYDAAIVDLHMPGMSGLDLLKQLRVMQASGMPYVPVMVLSADVTPESILRCEQAGARAFLAKPVVATRLLEVLADVAANTRAESGIQSVPALPVGDGVLDTAVLDELASLGMGDGFERKFIDQCLADVDASMGQLQGCGERQAWEDFREHAHALRGVASNLGLVQVAASSGEIMRMADWQLKGEWNARLGSLATALRNGRNALAARSAGAAHRDDSERSPS
>NZ_CP040438.1|WP_012480080.1|2192394_2193264_-|crotonase/enoyl-CoA-hydratase-family-protein
MSAVRPIITRPSQHPTLRITEEPERDVYWIHMHANLVNQPGRPCFASRLVDDIVDYQRELGDRLSASHALSPHVVLASDSDVFNLGGDLELFCRLIREGDRARLLDYAQRCVRGVHAFHAGLGTRAHSIALVQGNALGGGFEAALSCHTIVAEEGVLMGLPEVLFDLFPGMGAYSFLCQRISPRLAEKIMLEGNLYTASQLKEMGLVDIVVPVGEGVAAVEQVIKESRRIPHAWAAMREVNEIATMVPLHEMMRITEIWVDTAMQLGEKSLRTMDRLVRAQARRNGDPA
>NZ_CP040438.1|WP_154263421.1|2193464_2195141_-|long-chain-fatty-acid--CoA-ligase
MSLDRPWLQSYPKGVPAEIDVNEFHSVASVFDASVAKFRDRPAYSSFGKVLTYGETDALVTQFAAYLLGELKLKKGDRVALMMPNCLQYPVATFGVLRAGLTVVNVNPLYTARELKHQLVDAGVSALVVVDNFGDTVEQVIADTPVKHVVTTGLGDLLGAKGAIVNFVLKYVKKMVPNYHIKGAVRFKQALKLGSRHALPPVEVDHDDIAFLQYTGGTTGVAKGAMLTNRNLIANMQQASAWLSTSGIEPGKEVIITALPLYHIFALTANGLVFMKFGGCNHLITNPRDMKGFVKELKGTRFTAITGVNTLFNGLLNTPGFDEIDFSSVKFTLGGGMAVQRAVAERWKKITGVTLVEAYGLTETSPAACINPLTLPEYNGAIGLPIPSTDACIKDDNGNILALGEVGELCIKGPQVMKGYWQRPEETATAIDADGWLHTGDMAKMDERGFFYIVDRKKDMILVSGFNVYPNEVEDVIAMMPGVLEVAAVGVPDEKSGEVVKVVIVKKDPNLTAEMVKEHARANLTGYKHPRIVEFRKELPKTNVGKILRRELRDTPAQ
>NZ_CP040438.1|WP_049429885.1|2195363_2197046_-|choline-dehydrogenase
MSTHNEYDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRYNWAYKTDPEPFMNNRRMDCGRGKGLGGSSLINGMCYIRGNAMDYDNWASMPGLEDWTYLDCLPYFRKAETRDIGPNDYHGGDGPLRVTTPKAGNNELFAAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRSSTARGYLDLAKPRPNLTIVTHALTDRILFSGKRAVGVQWLHNDQPQRATARREVLLCGGAIASPQILQRSGVGPADLLRSLDIDLVHHLPGVGANLQDHLEMYLQYECKKPVSLAPALKLYNQPAIGAEWLFLGTGIGASNQFEAGGFIRSDAEFDWPNLQYHFLPVAINYNGSNPIKAHSFQMHVGSMRSPSRGRIHVRSKDPREHPSILFNYMSHDQDWREFRAAIRITREIFAQPALAPYSGREISPGSALQTDAQIDAFVREHAETAYHPSCSNKMGHADDPMAVVDGQGRVHGLEGLRIVDASIMPQVVTGNLNAPTIMMAEKLADVIRGRTPLARSTAPYYKANGAPVRKQG
>NZ_CP040438.1|WP_154263422.1|2197147_2198620_-|betaine-aldehyde-dehydrogenase
MTTLPVQQLYIHGQRVDATSGKTFKTVNPATGEVIAEVQVASQADVERAVQSAAEGQKVWAAMTAMERSRILRRAVEILRERNDELAHLETLDTGKALAETTTVDIVTGADVVEYYAGLATAIEGIQLPLRESSFFYTRREPLGVVAGIGAWNYPIQIAMWKSAPALAAGNAMVFKPSEVTPLTAIRLAEIYTEAGVPAGVFNVVQGPGREIGQWLTEHPVIEKISFTGGVATGKKVMASAASSSLKEVTMELGGKSPLVICDDADLDRAADIAVMANFFSSGQVCTNGTRVFVPRSMLAAFEAAVVERVKRIRIGDPMAAGTNFGPLTSFPHMENVLRYIESGKAEGARLLTGGGRATEGALANGAYVLPTVFSDCRDDMTIVKEEIFGPVMSILAYDDEDEVVRRANDTTFGLAAGVVSKDVSRAHRIIHRLEAGICWINTWGESPAEMPVGGYKESGVGRENGISTLGHYTRIKSVQVELGDYASVF
>NZ_CP040438.1|WP_154263423.1|2198659_2199250_-|transcriptional-regulator-BetI
MPKKGVEPVRREQLIRATFQTIDEIGMADATVATIAKKAGLSSGIVAHYFGDKDGLLNAAMRQILRELKDAVARYRADAGDDPREQLRAIVDGNFDDSQINGTAMRVWLTFWAASMHQPELARLQRANDQRLFSNLCHQFNRLLPHPQARLAARGLAAMIDGLWLRGSLVGGQFNAEKSRRIAYGYIDFQLQAGAL
>NZ_CP040438.1|WP_154263424.1|2199420_2200971_+|BCCT-family-transporter
MSSLAHPKRSPLRLNRFVFFSSSVSIGILGLLTVLYPESSEHWLQWAQAEVSAAFGWWYMLLIVLCLGFVLWLAFSPYGRIRLGHNEESPAFGYVAWVSMLFSAGIGIALLYYGAYEPLDHFLNPPGQPGGTVAAGREAMVLTFLHWGLHGWALYALVGVALGYFAYRRDLPLALRSALYPIFGERIHGRIGDMVDGFGILATLISMVTNLGIGALVVQSGLVYLFHIPDTPQVLVAIVLVMMVVATIGVVAGVEKGIAWLSNLNVRLLCGLLLFVLVTGPTLHLFDGLIQNTGDYLGAFVRKSFDMYLNDPKGREWMGSWTLFYWAWWIAWAPFVGLFVARISRGRTIREVIMGVLLIPLGFTLAWLSIFGNTAIDLVLNHGQAILGDVAQHDAAMTLFKLLEYLPAAPYVAGAAVVIGFVLFLTPVDSGTLMIANLCTRRVDDGVEDGHDAPIWLRVFWAVGITVASVGLLLAGNFSAMQTAVVLCGLPFSFTLAFYMWGLLKALRTDPDAPRR
>NZ_CP040438.1|WP_154263425.1|2201086_2201542_+|hypothetical-protein
MKRLLCGLLLSAAVPLRAEPMPPPMQQLDFPVLAVGDIGQFRVHVPAYAGGQGRVSYAAHALMPGSDDDRGYRFIAVACGDGGFTPMVHYEDRGVVCSRIGQAPHPAFEMVVTVLNTGASDGETVMPEGLRGLVYDVGPSAAPWRIHGVRP

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Crispr_ID: NZ_CP040438_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_7

3022609-3022711

Orphan

Consensus_repeat	Method
TTCGGTAGATGCCCACCTTGGTGGGC	CRISPRCasFinder

1 spacers

DEDDh,csa3

The CRISPR arrays of NZ_CP040438_7

>merge|NZ_CP040438|7|3022609-3022711|CRISPRCasFinder
TTCGGTAGATGCCCACCTTGGTGGGCATGGATCCAGGACGGCGCCAACCAAGGTTGGCAACTACCGGGGTACAGCGCTTCGGTAGATGCCCACCTTGGTGGGC

>NZ_CP040438|7|7|3022609-3022711|CRISPRCasFinder
TTCGGTAGATGCCCACCTTGGTGGGC	ATGGATCCAGGACGGCGCCAACCAAGGTTGGCAACTACCGGGGTACAGCGC
TTCGGTAGATGCCCACCTTGGTGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_154263985.1\|3014091_3014730_+\|FMN-binding-negative-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377290
NZ_CP040438.1\|WP_154263987.1\|3017516_3018884_+\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|223727
NZ_CP040438.1\|WP_014037740.1\|3014802_3015465_+\|carbonate-dehydratase	unknown	unknown	gnl\|CDD\|238448
NZ_CP040438.1\|WP_049422068.1\|3035680_3036829_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NZ_CP040438.1\|WP_149909403.1\|3024735_3029712_-\|NAD-glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|377452
NZ_CP040438.1\|WP_154263988.1\|3018883_3020323_+\|exodeoxyribonuclease-I	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236979
NZ_CP040438.1\|WP_049422134.1\|3015484_3016006_+\|3-hydroxyanthranilate-3,4-dioxygenase	unknown	unknown	gnl\|CDD\|183930
NZ_CP040438.1\|WP_005417414.1\|3022760_3023705_-\|5'-nucleotidase	unknown	unknown	gnl\|CDD\|377624
NZ_CP040438.1\|WP_154263986.1\|3016210_3017485_+\|kynureninase	unknown	unknown	gnl\|CDD\|130873
NZ_CP040438.1\|WP_154263991.1\|3035262_3035550_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_032127674.1\|3020319_3021006_+\|DUF2461-domain-containing-protein	unknown	unknown	gnl\|CDD\|274138
NZ_CP040438.1\|WP_154263989.1\|3021005_3021986_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381321
NZ_CP040438.1\|WP_154263993.1\|3037925_3039017_+\|5-methyltetrahydrofolate--homocysteine-methyltransferase	unknown	unknown	gnl\|CDD\|236539
NZ_CP040438.1\|WP_154263994.1\|3039074_3041759_+\|methionine-synthase	unknown	unknown	gnl\|CDD\|236539
NZ_CP040438.1\|WP_032127669.1\|3029962_3030619_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379522
NZ_CP040438.1\|WP_006453002.1\|3013770_3014085_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_006376667.1\|3023752_3024526_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|179876
NZ_CP040438.1\|WP_154263992.1\|3036982_3037912_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|369777
NZ_CP040438.1\|WP_154263990.1\|3022028_3022580_+\|DUF2939-domain-containing-protein	unknown	unknown	gnl\|CDD\|378575
NZ_CP040438.1\|WP_049422071.1\|3030618_3031887_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|169982

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_154263985.1\|3014091_3014730_+\|FMN-binding-negative-transcriptional-regulator	gnl\|CDD\|377290	pfam04299, FMN_bind_2, Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	1.19263e-48
NZ_CP040438.1\|WP_154263987.1\|3017516_3018884_+\|NAD(P)-binding-protein	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	1.41167e-39
NZ_CP040438.1\|WP_014037740.1\|3014802_3015465_+\|carbonate-dehydratase	gnl\|CDD\|238448	cd00883, beta_CA_cladeA, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	6.28252e-110
NZ_CP040438.1\|WP_049422068.1\|3035680_3036829_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.11419e-177
NZ_CP040438.1\|WP_149909403.1\|3024735_3029712_-\|NAD-glutamate-dehydrogenase	gnl\|CDD\|377452	pfam05088, Bac_GDH, Bacterial NAD-glutamate dehydrogenase. This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyze the reversible oxidative deamination of glutamate to ketoglutarate and ammonia.	0
NZ_CP040438.1\|WP_154263988.1\|3018883_3020323_+\|exodeoxyribonuclease-I	gnl\|CDD\|236979	PRK11779, sbcB, exonuclease I; Provisional.	0
NZ_CP040438.1\|WP_049422134.1\|3015484_3016006_+\|3-hydroxyanthranilate-3,4-dioxygenase	gnl\|CDD\|183930	PRK13264, PRK13264, 3-hydroxyanthranilate 3,4-dioxygenase; Provisional.	8.21737e-109
NZ_CP040438.1\|WP_005417414.1\|3022760_3023705_-\|5'-nucleotidase	gnl\|CDD\|377624	pfam06189, 5-nucleotidase, 5'-nucleotidase. This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences (EC:3.1.3.5).	1.99103e-153
NZ_CP040438.1\|WP_154263986.1\|3016210_3017485_+\|kynureninase	gnl\|CDD\|130873	TIGR01814, kynureninase, kynureninase. This model describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a Trp breakdown product and a precursor for NAD. In Chlamydia psittaci, an obligate intracellular pathogen, kynureninase makes anthranilate, a Trp precursor, from kynurenine. This counters the tryptophan hydrolysis that occurs in the host cell in response to the pathogen. [Energy metabolism, Amino acids and amines].	0
NZ_CP040438.1\|WP_032127674.1\|3020319_3021006_+\|DUF2461-domain-containing-protein	gnl\|CDD\|274138	TIGR02453, conserved_hypothetical_protein, TIGR02453 family protein. Members of this family are widely (though sparsely) distributed bacterial proteins about 230 residues in length. All members have a motif RxxRDxRFxxx[DN]KxxY. The function of this protein family is unknown. In several fungi, this model identifies a conserved region of a longer protein. Therefore, it may be incorrect to speculate that all members share a common function.	7.8704e-91
NZ_CP040438.1\|WP_154263989.1\|3021005_3021986_+\|aldo/keto-reductase	gnl\|CDD\|381321	cd19095, AKR_PA4992-like, Pseudomona aeruginosa PA4992 and similar proteins. Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.	3.23967e-73
NZ_CP040438.1\|WP_154263993.1\|3037925_3039017_+\|5-methyltetrahydrofolate--homocysteine-methyltransferase	gnl\|CDD\|236539	PRK09490, metH, B12-dependent methionine synthase; Provisional.	0
NZ_CP040438.1\|WP_154263994.1\|3039074_3041759_+\|methionine-synthase	gnl\|CDD\|236539	PRK09490, metH, B12-dependent methionine synthase; Provisional.	0
NZ_CP040438.1\|WP_032127669.1\|3029962_3030619_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379522	pfam14246, TetR_C_7, AefR-like transcriptional repressor, C-terminal region. This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae. It is found in association with pfam00440.	5.58571e-15
NZ_CP040438.1\|WP_006376667.1\|3023752_3024526_-\|NAD-kinase	gnl\|CDD\|179876	PRK04761, ppnK, inorganic polyphosphate/ATP-NAD kinase; Reviewed.	7.17968e-158
NZ_CP040438.1\|WP_154263992.1\|3036982_3037912_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	2.16696e-22
NZ_CP040438.1\|WP_154263990.1\|3022028_3022580_+\|DUF2939-domain-containing-protein	gnl\|CDD\|378575	pfam11159, DUF2939, Protein of unknown function (DUF2939). This bacterial family of proteins has no known function.	4.28448e-30
NZ_CP040438.1\|WP_049422071.1\|3030618_3031887_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|169982	PRK09578, PRK09578, MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit.	3.72655e-88

>NZ_CP040438.1|WP_154263990.1|3022028_3022580_+|DUF2939-domain-containing-protein
MKKLTALVGLLVLALAAWWFGGPYMTVNGLSKAIEQRDTARLQRYVDFPRVRSSLRAQLNDYLVRQADPDVAASPFGALLYGLGDQLGGAAVETLVTPTGIGAMLQGHVLWKRGRNELQGGDAFGPTEPARPLKHAEHHFEALDRFVIDVDRGPGQPPLKVVLEPQGLRWKVVDLQLGMSGSP
>NZ_CP040438.1|WP_154263989.1|3021005_3021986_+|aldo/keto-reductase
MPLAQQRRTLGRTGLAVSPVGLGCSGFWGHRRFPEQSAAHVVEHALAQGVNLLDTGHNYSGFHAEPRLGRILRPLLKRYPREALVISSKGGTLTGQAGVSGAEQRNFSPAAITASCEASLRNLGLDYLDIYQLHGASQHDINDDLLAALQRLRERGLIRHTGINTHTASTLRWMIDHPTLFDVVLLDYNALQQDREPLIDQLHAVGIGVLAGTVLAQGHLLPPRPHLPRPADAWYLARAWLKPSSRQLMRSARNMRKALAAIRSQRPAQTAFAYALGHPGVASGILGTTRTASLDEVLATRLEALTAAERQQLVDAFGDGRGSPSH
>NZ_CP040438.1|WP_032127674.1|3020319_3021006_+|DUF2461-domain-containing-protein
MSTYFSDASFKFLRSLARHNDKAWFNDHRQQYEDHVRQPFLRLLGDLQPALAEVSDHFRADTRGVGGSLFRIHRDARFSNDKSPYKTWQGARLFHERRREVAAPSFYVHLQPGESFVGAGLWHPEPETQRRVRHFILDNPGSWKAAAHAPALRKRFDFEESEKLVRPPRGFPADFEFIDDLKHRNWVMWRSLDDATMTGPRLLSTLGKDLAALGPFVDYLCAALDLEF
>NZ_CP040438.1|WP_154263988.1|3018883_3020323_+|exodeoxyribonuclease-I
MADSFLFYDLETFGQDPRRTRISQYAAIRTDADLNEIDTPVSFFVRPADDLLPSPMATLVTGITPQQALAEGISEAEAFDRINEQLSRPGTCALGYNTLRFDDEFVRYGLFRNFHDPYEREWRNGNSRWDLLDMLRLMRAMRPDGIQWPLREDGATSFKLEHLAEANNVREGDAHEALSDVRATIGMARLFKQSQPRLWEYALKLRDKRFVGSLLDVAAMKPVLHISMRYPASRLCAAPVLPLAAHPTINNRVIVFDLEGEIDDLLELPAEVIAQRLYMRASELPEGVARVPLKEVHLNKVPALIAWNHLRADDHARLGLDVAAIEAKVERLRAFAPQLAEKARQVYNQPRAATVADFDASLYDGFLGNGDKPLLALARTTAPEQLAALEGRFRDPRLPELLFRYRARNHPDSLAPAERQRWQDYRRQRLLGDGGLGELNLPQYQQQLDALTAEAPDDARRQALLQSLRDWGQHLQETL
>NZ_CP040438.1|WP_154263987.1|3017516_3018884_+|NAD(P)-binding-protein
MIAHASRSLSIIGAGLAGSLLAILLSRQGWRITLYERRGDPRVADYESGRSINLALAERGRNALRQAGVEDEVMARAVMMRGRMVHPREGEPQLQRYGRDDSEVIWSIHRSDLNTTLLELAEQAGATVHFHRRLHTVDFDAGYARFIDDRDDSPHDIRFDTLIGADGAGSALRAAMNRRAPLGEDIAFLDHSYKELEIPPAADGSFRIERNALHIWPRGHYMCIALPNHEGTFTVTLFLPNQGDPSFATVNTGTQAEALFAREFADTLPLIPNLRADWEQHPPGLLGTLTLERWHQQGRAVLIGDAAHAMVPFHGQGMNCAFEDCVALARHLMEADDLEAAFAAFEAERKPNARAIQQMALENYLEMRDRVADPAFLLQRELEQELQRRWPTRFVPHYTMVTFLHTPYAEALRRTELQRDMLVAATAGHDSLDNIDWTALEAQIHAQLPVLEGAH
>NZ_CP040438.1|WP_154263986.1|3016210_3017485_+|kynureninase
MSDLLSRTHAIALDAADPLRPLRNEFLIPRHGGGEQTYFVGNSLGLQPRGAQAAVQEVMKQWGELAVEGHFTGPTQWLSYHRLVSAQLARVVGALPSEVVAMNTLSVNLHVMMVSFYRPTAERPVILMEAGAFPTDRHAVEAQIRFHGFDPAECLVEVQPDEANGTISLTAIEHAIAEHGSRLALVLWPGVQYRTGQAFDLDAITRAARLQGARIGFDLAHSVGNLPLRLHDVAPDFAVWCHYKYLNSGPGAVAGAFVHERHHRDTSLPRFAGWWGHEESTRFQMAPQFTPAIGAEGWQLSNPPILGLAPLRASLDLFERAGMEALRSKSLALTGMLEALVRARLSGVLDIITPAEPQRRGCQLSLRVIGGRERGRALFEHLRGIGVLGDWREPDVIRISPTPLYNRYLDVHHFVEEVEAWAGL
>NZ_CP040438.1|WP_049422134.1|3015484_3016006_+|3-hydroxyanthranilate-3,4-dioxygenase
MLASPINLHAWIEENRHLLKPPVGNKMIDNGDFIVMVVGGPNSRTDFHYDEGPEWFYQLEGEMVLKVQEDGAVRDIPIRAGEIFLLPAKVPHSPRRPPGGIGLVVERKRLPHEMDGVIWHCERCNHKLHEEYFPLQNIETDLPKVFARYHASLELRTCSECGHVDPLPAPAAG
>NZ_CP040438.1|WP_014037740.1|3014802_3015465_+|carbonate-dehydratase
MKDIHKLLQNNRDWADRIEKEDPEFFHQLAKQQHPEYLWIGCSDSRVPANQIIGMAPGEVFVHRNVANVVAHTDLNCLSVVQYAVDQLKVKHILIVGHYGCGGVHACLHNTRVGLADNWLRHVGDVMQKHTGILDAIETDELKHARLCELNVIEQVANLCRSTIVQDAWARGQKLMVHGWVYSLKDGRVREMGIDVGSQEELQPAYEKALSYVPRKGKRD
>NZ_CP040438.1|WP_154263985.1|3014091_3014730_+|FMN-binding-negative-transcriptional-regulator
MFTPRAFAETDLLWLDRLLARDPFVTVLTPGSDGLPELTRMPVLYRRDGDQIELRGHWARANPQSRHRGAAKVLIDGPHGYVSASWYPDKEPAARVPTWNYAAAELRGQLQTFDDTEALAELVGAISDRFEASVGQAWQFDASRAEHGPELRAIVGFRLQVEQVQLKLKLSQNHPDANQRAVIAELEQLGTPASTELAQWMRWHREQAARSD
>NZ_CP040438.1|WP_006453002.1|3013770_3014085_+|hypothetical-protein
MNDITASRDSWWLASLGNTLIWARLRVRPAGTAEVLDSDGNTLSYDSEDTARSQLFDAEFVEYDGLDEEDALVRGFSLHEVQPPQADSDEGLRGRMIQSLGGRA
>NZ_CP040438.1|WP_005417414.1|3022760_3023705_-|5'-nucleotidase
MGDNSPRLLTVAVTSRALFDLEESHALFESDGVAAYAEFQRQHEDDILGPGVAFPVVRKLLALNQGASPENPRVEVILLSRNSADTGLRIFNSIQHYGLGIIRATFTAGEPTWPYVKPFGTDLFLSANPESVRSALRHGIAAATILPKPPGETAAAAADQIDTGRPAGQLRIAFDGDAVIFGDESERISREQGVEAFGRHERERAREPLSGGPFRGFLSALHTLQEVFPAGDSAPIRTALVTARSAPAHERVIRTLREWGVRLDEALFLGGRHKGPFLQAFGADIFFDDSQHNIDSAREHVAAGHVPHGVANEG
>NZ_CP040438.1|WP_006376667.1|3023752_3024526_-|NAD-kinase
MSDTPRIAFLASTTEPAQMARAAMVSRYGDHAPEQADVLCPLGGDGFMLQTLHRHGHLGKPVFGMKLGTVGFLMNQYRGDDDVQARIARAEPANLRPLEMVALTESGTSTGSLAYNDVSLLRQTRQAAHIGIDLNGQERVAELIGDGVLVATPAGSTAYNYSAHGPVLPLGSHTIALTPLAPYRPRRWRGAILKADTEVRFRVLDPYKRPVSVTADSHETRDVVEVTIRESKDRRVTLLFDPEHNLEDRILSEQFVF
>NZ_CP040438.1|WP_149909403.1|3024735_3029712_-|NAD-glutamate-dehydrogenase
MKPQKTAAKTVKNKTKPAESEVAVTAGFSLEPVYTALRKRYPAAAQAEAVAFATDFYKRMESDEFPHHSAEEWAALAAETLEFARARKAGKANVRVFNPTAKANGWESPHTVLQIVNDDMPFLVDTVTMSLAEQGVGVHVLGHPVLRFTRDKAGKLVKVGEGDAESVMLLEIDRQPAEAMAAIEQAISKALDEVRAIVRDWQPMKDKALALADDLGSRQLPVDDASRKEAQEFLRWAADNHFTFFGYREYRVEKQGKEEVLAPLNDTGLGLMRGKDKSAARPVKTLAAQGLNTTSGLKDALILTKTNARSRVHRAGYMDYIGVLEFDAKGKIIGEQRFLGLFTSSAYNRRPWEIPLVRQRHEHVMKQSGLASASHSGKALRHILETLPREELFQSSEDELFRTAMGVLGLQERVRSRLFLRRDKYSRFISALVYLPRERFNTDVRLRIEAMLKDALHGEYVDSSVVLGESPLAQVHLIVRPKPGEMLDVDTAELEQKLAQVLRNWQDDLREALVTRHGETEGLRIAARIGKALPAGYIEDNSTAVAANDVSQLDALTGPDDLRLSLQAVPRESGDGLRLKLYRQLDDIPLSDALPMMENMGLRVIAERPYRLSVDNAPVYVQDFEVESTAGAIDAASVDEAFGETFARVWHGDAENDGFNRLVLAAGLHWRQVAMLRGYCKYLLQTGVPFSQAYVEGTFARYPLLARLLVELFEARFDPATGHESKDDIAAGQAQLKAHFDVLAAGDDATLKVLKTVVDARKGDRDAQMQAARDALLKLMDRVSSLDEDRILRSFMGVIDATLRTSYYQTDANGQHGHVISFKFDSALVPDLPKPRPYREIFVYGPRVEGTHLRFGAVARGGLRWSDRREDFRTEVLGLVKAQMVKNTVIVPVGAKGGFFAKTPPVNGDRDAIFANGVACYKLFIQGLLDITDNIVNNKIVPPVDVVRHDMDDPYLVVAADKGTATFSDIANGLAIAHGFWMGDAFASGGSVGYDHKGMGITARGAWESVKRHFRALGRDSQSQDFTAVGVGDMSGDVFGNGMLLSRHIRLVAAFDHRHIFLDPNPDAATTFVERERLFTVPRSSWADYDAKLISKGGGVYPRSLKSIEITPQVREVLGLDENVKALSPNDLMSAILKAPVDLLWNGGIGTYVKAASEQHSDVGDRANNALRVNGGELRCKVVGEGGNLGMTQLGRIEAAQAGVLLNTDFIDNSAGVDTSDHEVNIKILLNDVVRAKKLTVEQRNKLLASMTDEVAELVLNDNYRQNQALSLMERMAVKRLGSKQHFIRTLEQQGLLDRQIEFLPSDAELSQRKARGQGLTRPELSVLLSYSKLVAFAQLLDSDIPEDPYLSKELQRYFPTPLQKKYADAMERHRLKREIIATAVTNQTINRMGATFLMRMQEDTGRSIAEVAKAYTISRETLDARALWAQIDALDGKVPESVQIDALEVIWKLQRSFVRWLLSRPGAMPGITEAVNRYQGPFNDIRVASGVLPDSQRPTYEALVAEWKEKGLPSALAQQLAELHFLEPAFDIIELARTRKLKPVDVSKVHFRLGDALQLPWLFEQVDALEVNGRWHAVARGVLRDELAANHRNLAGQVLGTKGSSAEAKVAAWMGRDDNSLRFTLAMLAELAEQKTLDYPTVSVAVQRLGQLAAHGA
>NZ_CP040438.1|WP_032127669.1|3029962_3030619_+|TetR/AcrR-family-transcriptional-regulator
MNPAYLPVALDARDERVFDAVRELLAQQGMQMSMDAVAQHAGCSKQTLYSRYGNKQELLRRVMQRHVGHATGAMVRALRTDDLRASLLQFATDFLEHFNQPHVGQACRLIAADAAQFPEEARTLYRHGAGALTLHLAEWIETVCMRGQLRHDDPHFMAELLLSMIAGQDFDKQRFHTPHRDDAQLRRRWAEFSVDSFLRAFAPQPSAAPSSNQPRSSS
>NZ_CP040438.1|WP_049422071.1|3030618_3031887_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MTAPLRTLALTCAVAVALAACKKPEQQTPPPPEVGVIDAKPQTLPLQRELVGRLSPFRSADVRARVPGVLLKRVYQEGSQVKQGQPLFLIDPAPLRASLNASEAQLASARATYANAKVAADRARSLAPQQFVSKSDLDNAESAERTALAAVKQAEAAVTSSRISLGYTEVTAPISGVANKQQVTEGALVGQGDVTLLTTVDQLDPLYVNFSLSVDELTQLRAQQAKGALALSGDGKATVNVKLADGSTYSEPGTLDFSSTTVDPATGAVSLRALLPNPQQILLPGAFVSFQANLGERNNAYLVPQQALLRDTTGGYVMVVGADGKVVRKNVKTDGAQNGNWLVSDGLAAGDKVIVAGVQKVKEGAPAVAKPWTPGQDANGKPAAGGAAPAGAAPAAGKAPADAAKPEQADAAKPAATDSNKQ
>NZ_CP040438.1|WP_154263991.1|3035262_3035550_-|hypothetical-protein
MIYRGWGFMTLVTPIAAILLLAYFFPHEGSKGNTPLAQVLLGAGIGAAVNVLLGLWLNRAPRQKGVAAPHHFFFVPMQWAALVIVAVCAVVALLR
>NZ_CP040438.1|WP_049422068.1|3035680_3036829_-|acyl-CoA-dehydrogenase
MDFSFTEEQLMLQDVARRIAQEKIAPSAEHHDRTGEFPLDNIRLLGENGLMGIEVPTEYGGAGMDPVAYVLAMVEVAAADAAHSTIMSVNNSLFCNGILTHGTEEQKQTYVRAIAEGEAIGAFALTEPQSGSDATAMRCRAVKQADGTFVINGKKSWITSGPVAKYIVLFAMSEPDKGARGITAFIIDTDKAGFGRGKTEPKLGIRASATCEIEFNDYVAQAEDVLGQEGEGFKIAMSVLDAGRIGIASQAIGIARAAYEATLEYVKERKAFGAAIGTFQMTQAKIADMKCKLDAALLLTLRAAWVKGQGKRFSTEAAVAKLTASEAAMWITHQAVQIHGGMGYSKEMPLERYFRDAKITEIYEGTSEIQRLVIARNETGLR
>NZ_CP040438.1|WP_154263992.1|3036982_3037912_+|metalloregulator-ArsR/SmtB-family-transcription-factor
MDLEDWSTRLKVFADATRVRLLALLEQEELTVAELSAITRLAQPRVSTHLARLKEAGLVRDRRAGVSAYYRFDEAQLDPAQRALWHALSNGSDDPLLRQDAERVAAVLAHRASDQNWADSVAGDMERHYSPGRTWEALARTALPLLETGDVLDIASGDGVLAELVAPHAKRYICIDTSARVVAAASERLRRLPNVEVREGDMHALPFKDGNFDLVVLMHALTYASKPAQAVTEAARVLRSGGRLLLCSLARHEHKAAVEAYGHVNLGFSDKELRRFVDKAGLQVSSLETVTREKRPPHFEVISLIANKP
>NZ_CP040438.1|WP_154263993.1|3037925_3039017_+|5-methyltetrahydrofolate--homocysteine-methyltransferase
MPALPWLHPDRANALLDALRERILIIDGAMGTMIQRHGLQEDDYRGERFAGGYDHVHGPACDHGTPEGHDLKGNNDLLLLTRPQIVADIHTAYLEAGADLVETNTFNATSVSQADYYLEHLVYELNKAGAAVARTCCDTVAATTPGKPRFVIGVIGPTSRTASISPDVNDPGFRNTSFDELRDTYREAIDGLIDGGADTIMVETIFDTLNAKAALYALEEAFDARGARLPVMISGTITDASGRTLSGQTAEAFHASLAHARPLSIGLNCALGADAMRPHVETLAQIADCYVSAHPNAGLPNAFGEYDETPEDMASTLRGFAEDGLLNLVGGCCGSTPDHIRAIAEAVAGLPPRALPGVQEQAA
>NZ_CP040438.1|WP_154263994.1|3039074_3041759_+|methionine-synthase
MTPVRPTRLSGLEPLVITPDLLFINVGERTNVTGSAQFRKLIKEGRYEEAVDVARQQVASGAQILDVNMDEGLIDSEAAMTRYLNLIMSEPDIARIPVMVDSSKWSVIEAGLKCLQGKSVVNSISLKEGEALFREHARKVLRYGAAAVVMAFDESGQADTCARKVEICTRAYRILVDEIGFPPQDIIFDPNIFAVATGIEEHDNYAVDFIEATRIIKQTLPHCHVSGGVSNVSFSFRGNETVRQAIHSVFLYHAIAAGMDMGIVNAGAMPIYDELEPELRERVEDVILNRRSDATERLLEIAERYKGKKGAAKTEDLAWREKPVAQRLAHALVHGLDAFVEEDTELARQASSRPLDVIEGPLMDGMNIVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPYIEAEKARSGDTAKSNGKIIMATVKGDVHDIGKNIVGVVLACNNFEVVDLGVMVPAQKILDAAREHNADLIGLSGLITPSLEEMSHVAREMQRQGFDLPLLIGGATTSRAHTALKIDPHYKAPTVWVKDASRAVGVAQSLISRDLREAFVAANEADYAEIRARHRNRGDAKRLVSLEHARGQKFQGGWDTYTPPAPNQPGLHVFDDYPLAELVDYIDWTPFFQAWELAGKFPAILTDEIVGTQASDLYRDACAMLERIVNEKWLTAKAVFGLWPANSIGDDVRVQHPQGETTLHFLRQQVDKPVERPDFCLADFIAPADSGKQDWIGAFAVTAGIGIDAHVARFEADHDDYNAILLKALADRFAEALAERLHQRVRTEFWGHEHAETLDNEALIDEEYSGIRPAPGYPACPEHSEKRRLFDLLQAEANAGMELTESFAMLPTAAVSGYYFSHPQSQYFVVGRLSREQVGDYARRKGVDRAQAERWLASNLDYDPE

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Crispr_ID: NZ_CP040438_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_8

3735014-3735112

Orphan

Consensus_repeat	Method
CGCGCCATCCACGCATGGCGTGGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040438_8

>merge|NZ_CP040438|8|3735014-3735112|CRISPRCasFinder
CGCGCCATCCACGCATGGCGTGGATCCACCCACCAACGCGGTAGTGCCGGCCGCTGGCCGGCAACCTCATGCATCGCGTCATCCACGCATGGCGTGGAT

>NZ_CP040438|8|8|3735014-3735112|CRISPRCasFinder
CGCGCCATCCACGCATGGCGTGGAT	CCACCCACCAACGCGGTAGTGCCGGCCGCTGGCCGGCAACCTCATGCAT
CGCGTCATCCACGCATGGCGTGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_154264259.1\|3742854_3744114_+\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224376
NZ_CP040438.1\|WP_004154430.1\|3730343_3731513_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NZ_CP040438.1\|WP_154264252.1\|3726201_3727404_+\|lipase	unknown	unknown	gnl\|CDD\|367570
NZ_CP040438.1\|WP_032128827.1\|3744122_3744986_+\|prepilin-peptidase	unknown	unknown	gnl\|CDD\|224900
NZ_CP040438.1\|WP_154264250.1\|3722705_3723212_-\|DUF4166-domain-containing-protein	unknown	unknown	gnl\|CDD\|379359
NZ_CP040438.1\|WP_005410793.1\|3729447_3730323_-\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NZ_CP040438.1\|WP_088479593.1\|3742082_3742493_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|236718
NZ_CP040438.1\|WP_029379759.1\|3725105_3725993_+\|outer-membrane-protein-assembly-factor-BamD	unknown	unknown	gnl\|CDD\|274513
NZ_CP040438.1\|WP_154264254.1\|3733592_3734966_+\|response-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP040438.1\|WP_154264256.1\|3738036_3739581_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235967
NZ_CP040438.1\|WP_154264257.1\|3739577_3740042_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377229
NZ_CP040438.1\|WP_049401617.1\|3731918_3733532_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|236901
NZ_CP040438.1\|WP_154264251.1\|3723232_3724003_-\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|182677
NZ_CP040438.1\|WP_080291790.1\|3724002_3724992_-\|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD	unknown	unknown	gnl\|CDD\|183020
NZ_CP040438.1\|WP_154264258.1\|3740031_3741969_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154264253.1\|3727573_3729208_-\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NZ_CP040438.1\|WP_154264261.1\|3745876_3746791_+\|transposase	unknown	unknown	gnl\|CDD\|226077
NZ_CP040438.1\|WP_049481722.1\|3746802_3747189_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154264255.1\|3735117_3736845_-\|type-IV-A-pilus-assembly-ATPase-PilB	unknown	unknown	gnl\|CDD\|274186
NZ_CP040438.1\|WP_154264260.1\|3744997_3745609_+\|dephospho-CoA-kinase	unknown	unknown	gnl\|CDD\|234620

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_154264259.1\|3742854_3744114_+\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224376	COG1459, PulF, Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion].	1.37635e-150
NZ_CP040438.1\|WP_004154430.1\|3730343_3731513_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_CP040438.1\|WP_154264252.1\|3726201_3727404_+\|lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	5.39255e-06
NZ_CP040438.1\|WP_032128827.1\|3744122_3744986_+\|prepilin-peptidase	gnl\|CDD\|224900	COG1989, PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	7.20945e-59
NZ_CP040438.1\|WP_154264250.1\|3722705_3723212_-\|DUF4166-domain-containing-protein	gnl\|CDD\|379359	pfam13761, DUF4166, Domain of unknown function (DUF4166). This domain is often found at the C-terminus of proteins containing pfam03435.	2.90316e-22
NZ_CP040438.1\|WP_005410793.1\|3729447_3730323_-\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NZ_CP040438.1\|WP_088479593.1\|3742082_3742493_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|236718	PRK10574, PRK10574, putative major pilin subunit; Provisional.	4.23508e-24
NZ_CP040438.1\|WP_029379759.1\|3725105_3725993_+\|outer-membrane-protein-assembly-factor-BamD	gnl\|CDD\|274513	TIGR03302, OM_YfiO, outer membrane assembly lipoprotein YfiO. Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking].	5.12742e-90
NZ_CP040438.1\|WP_154264254.1\|3733592_3734966_+\|response-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NZ_CP040438.1\|WP_154264256.1\|3738036_3739581_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|235967	PRK07208, PRK07208, hypothetical protein; Provisional.	0
NZ_CP040438.1\|WP_154264257.1\|3739577_3740042_-\|hypothetical-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	1.55612e-14
NZ_CP040438.1\|WP_049401617.1\|3731918_3733532_+\|PAS-domain-containing-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	8.81116e-39
NZ_CP040438.1\|WP_154264251.1\|3723232_3724003_-\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|182677	PRK10723, PRK10723, polyphenol oxidase.	1.48462e-87
NZ_CP040438.1\|WP_080291790.1\|3724002_3724992_-\|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD	gnl\|CDD\|183020	PRK11180, rluD, 23S rRNA pseudouridine(1911/1915/1917) synthase RluD.	7.07678e-148
NZ_CP040438.1\|WP_154264253.1\|3727573_3729208_-\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NZ_CP040438.1\|WP_154264261.1\|3745876_3746791_+\|transposase	gnl\|CDD\|226077	COG3547, COG3547, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	5.33342e-24
NZ_CP040438.1\|WP_154264255.1\|3735117_3736845_-\|type-IV-A-pilus-assembly-ATPase-PilB	gnl\|CDD\|274186	TIGR02538, Type_IV_pilus_assembly_protein_PilF, type IV-A pilus assembly ATPase PilB. This model describes a protein of type IV pilus biogenesis designated PilB in Pseudomonas aeruginosa but PilF in Neisseria gonorrhoeae; the more common usage, reflected here, is PilB. This protein is an ATPase involved in protein export for pilin assembly and is closely related to GspE (TIGR02533) of type II secretion, also called the main terminal branch of the general secretion pathway. Note that type IV pilus systems are often divided into type IV-A and IV-B, with the latter group including bundle-forming pilus, mannose-sensitive hemagglutinin, etc. Members of this family are found in type IV-A systems. [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP040438.1\|WP_154264260.1\|3744997_3745609_+\|dephospho-CoA-kinase	gnl\|CDD\|234620	PRK00081, coaE, dephospho-CoA kinase; Reviewed.	5.66399e-87

>NZ_CP040438.1|WP_154264254.1|3733592_3734966_+|response-regulator
MNETRSALVVDDERDIRELLVLTLGRMGLRISTAANLAEARELLASNPYDLCITDMRLPDGNGIELVSEIAQHYPRTPVAMITAFGSMDLAVEALKAGAFDFVSKPVDISVLRGLVKHALELNNTERPAPGPATEQAARLLGASPAMDVLRTTIGKVARSQAPVYILGESGVGKELVARTIHAQGARAAGPFVPVNCGAIPGELMESEFFGHRKGSFSGAHADKPGLFQAAHGGTLFLDEVAELPLQMQVKLLRAIQEKSVRAVGAANEEPVDVRILSATHKDLAELVEDGRFRHDLYYRINVIELKVPPLRERRQDLPELAAAVLARLARSHGRATPLLAPSALEALAQYTFPGNVRELENILERALALAEEDCIGADDLRLPQHAPRAPGSAAPAEAVADLQPGGAALPSYIEQLERSAIQRALEENRWNKTRTAAQLGITFRALRYKLKKLGME
>NZ_CP040438.1|WP_049401617.1|3731918_3733532_+|PAS-domain-containing-protein
MSPSASLIDRIESIPRRELYFFALYRVLIAAVIAGLLYSPLSGMVGEAHHPRLADTVAAIYLLLSLLALAIGRNERWLRPIVVSSVLVDIIAATLLAHALPGASAGISMSLLFNIAAAATLLPLSWGLGLAVAASLATGTEYLWKVLEGGDPTRTLAELAMFATSYLALAFISYQVGNRARRNQQLANQRGDEVANLFQINELIIRRMRTGVLVVDADNRITLANEAASMLLGDNDGIGETGRLDLASAAPELARRLQRWRNGWAQDELPLQLNPDQPEVQPRFARLLAGSELALVFLDDSSVVSRRAESLTLSAMGRFSASLAHEIRNPLAAINYAVQLLEEGTGFNESDRRLLQIIRQQCQRTNGIVESVLGLARRERATPENVDLVAFVRRFVLEYKQGQTLETDSIEPIISDTAVMAQVDSKHLYQVLTVLVHNALKYGRIGQQPARVRLRVAQHERSAVIDVMDRGPGIPESVAAQLFRPFFTTSEHGTGLGLYIARELCRANQARLDYIPVPAGGSCFRLVLPGPHTLLPT
>NZ_CP040438.1|WP_004154430.1|3730343_3731513_-|ADP-forming-succinate--CoA-ligase-subunit-beta
MNFHEYQSKQLLAEYGIPVPAGKVAATPDEAVAAANSLGQGPWMVKAQIHAGGRGKAGGVKFCKTTDDVKAAAAKMLGTKMATYQTAGVELPVNLVLVTTAGEIVKELYLSVLVDRGTKTITYIASSEGGVEIEQVAAETPELIHSLNVDFVEGVQGYHGRDFGFKLGLTAKQAGQFASIMVNLYRLFNEKDLALVEINPLAILDDGNLYALDGKFDSDDNAAFRQKALVAMRDKTQEDPTEVIASELDINYVTMDGNIGCMVNGAGLAMATMDVIKLNGGEPANFLDVGGGANKQRVIEAFKLILSSDKVEGIFVNIFGGIVRCDMIAEGIIAAVKEVGVKVPVVVRLEGTNVEEGKQLLRDSGMAIIPADNINDGAKKIVEAVKNAA
>NZ_CP040438.1|WP_005410793.1|3729447_3730323_-|succinate--CoA-ligase-subunit-alpha
MSVLINKNTKVIVQGFTGQQGTFHATQMIEYGTQVVGGVTPGKGGTTHIDLPVFNTVADAVQSTGANASVIYVPPPYAADAILEAAAAGIKVIVCITEGIPVLDMLRVKNVLTRSHPDTVLIGPNCPGVITPGECKIGIMPGHIHQPGKIGIVSRSGTLTYEAVKQTTEVGLGQSTCIGIGGDPINGLNFVDCLKLFNEDPQTEGIIMVGEIGGDAEEAGAEYIKNHVKKPVVGFIAGASAPAGKRMGHAGAIASGGKGTAEGKFAAMEAAGVVTVRSPGDLGAAIAKLVK
>NZ_CP040438.1|WP_154264253.1|3727573_3729208_-|NAD+-synthase
MASIRIAMAQFDFPVGDVAGNTERIIEMIGQARDEYGAELVMFPELAVSGYPPEDLLLRPGFLYECEQAMARIAAACRGITAVVGWPQAAGAVVYNAASVLRDGLVEQTYRKRELPNYAVFDERRYFDVDPDGGSCVFEVNGIPVGLLICEDLWFAEPLADTVRAGAQLVVVPNASPYERGKHAQRDAVLAARTRESGAAIAYLNVVGGQDALVFDGASVVADGDGTVHPAAAAFVDQWLVVEYDGESRRFMPHVWMDDGDESMDALAWRAVTRGIQDYCRKNGFKKVWLGLSGGIDSALVLAMAVDAMGAENVTAVRLPSRYTAGLSNDLAAEQCQALGVKLEAVSIEPAFKGLMEALAPMFEGTAPDVTEENLQSRSRGVILMALANKFGGLLLTTGNKSEYAVGYATIYGDMCGGYAPLKDLYKTEVFGLSKWRNTVGGAPVIPPAVISRPPSAELRENQLDQDSLPAYDVLDGILYRYIDQEQSRTEIVAAGYDAAVVDRVLRLVRISEWKRHQAAPGPKVSRRAFGRERRYPISNGYKG
>NZ_CP040438.1|WP_154264252.1|3726201_3727404_+|lipase
MTLPPRRFRPLACLLATALLALSSGPLAAAPGAPGDLLSAAPYRASWVPSKAAQAYKLHYRTPDLRGQLAEGTGLLYLPAGAAPAGGWPVVSWAHGTQGIADRCAPSVSGPYQPERDRRFLDQFLAQGYAVVAADYQGLGSPGEHAYLHVRTAARNAIDLVKASRQYLGNAALSPRWVSVGHSQGGAAALTAGHLAPTYGGPSLHYRGSFTTGTPTAVELTALVMKPDNRTANPGALNAYHAYLLDGLLQVAPQIDRVLSDTGRARVAVAREQCLGELATTLDGADTGSMFTAPLTSVPGIWAVLYDYLGVPRRGFSQPLMLGHGSEDRDVPYLTTLLYAAGLALRGEPVAFRRYPVDHRGTLDAAATDGLAFVRARLGDGRFNDAAETASLEQLLEDAR
>NZ_CP040438.1|WP_029379759.1|3725105_3725993_+|outer-membrane-protein-assembly-factor-BamD
MIRRSAMLSAPVRLTALLLVLVIAATGCHRGAKKGDRPDEGTPVEQLYEKSHKLMQGGNWSGAEASFRRLVAQYPYGPYTEQAMIETAYAQYKAGKHDDAVSSIDRFIRTYPTHRNIAYLYYLRGLANSNRSTVFLRRVWSLDASRRDLSTPHQAYSDFNIVVDRYPNSRYAADARQRMLELRDVFAQHELDNALYYMRRGAWVSAAGRANYLLETYPQSAFQYDAVAVLADSYTHLGNKTLADDARRVLQLNQPDHPWLEGKWPKYPWMIRKLNPFAGEKSASTGQRNARLEKK
>NZ_CP040438.1|WP_080291790.1|3724002_3724992_-|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD
MSEQPSESARQAIVPDTAAGRRFDAVVAELFPEYSRSRLTEWIKAGEVLLDGAQVRPRDPLRGGELVTLNVVLETQTDAQPEDIPLDVLFEDEHLLVINKPVGLVVHPGAGNHSGTLVNALLFRDPSVAVLPRAGIVHRLDKDTSGVMVVAKTLEAQTALVEQLAARDVHRQYLAIVMGALVAGGTADAPIDRHPRDRLKMAVREDGKEAITHYRLRERFRAHTALECRLETGRTHQIRVHMAHVRHPIIGDPLYGGALKLPKGASDELVAALRGFKRQALHAETLEFTHPITGEPVRNTAPVPDDMLHLMKVLREDSEAFAARERDRW
>NZ_CP040438.1|WP_154264251.1|3723232_3724003_-|peptidoglycan-editing-factor-PgeF
MAAALPLLQADWPAPPGVHALTTRRHGAGISPAPFAQFNLGNRHAADGDTPANVEHNRQLLQQGLALPSAPHWLRQVHSSTVLRFSAPPVVGASEPVADAAVTSVPGVVLAILTADCLPVVFAAADGSEVGAAHAGWRGLADGMLEATVAAMQTPPAQLRAWLGPAAGPADYEIGEEVFHAFVGHDPAAEAAFVATRQGHWKVDLFALARQRLQAAGMDPAQVYGGTVSTMADPDLYSHRRDRRTGRMATLAWIAP
>NZ_CP040438.1|WP_154264250.1|3722705_3723212_-|DUF4166-domain-containing-protein
MLGPAFATLATPVQALHAAPLPCRYVGQARIVRGRHWLVPLLAALARLPKDGDALPTEVAFSAHGQGEQWARRFGRWPMVSRLWAHEGYLREQLGAVRFEFDLQAREGGIDWSVRRVWAFGLLPLPKRWFGGVRCREAWHGQRYTFLVDVTLPWAGALIRYEGWLEPQ
>NZ_CP040438.1|WP_154264255.1|3735117_3736845_-|type-IV-A-pilus-assembly-ATPase-PilB
MSAVTTPNLVGITGLARRLVQDGALDEASARDAMAKATAARQPLPTWFAQNKLVSASQLAAANAVEFGMPLFDVSTFDTSQNAMSLVSEELLRKHNVLPLFKRGGKLFVGTSNPTHALDEIKFHTNLVVEPILVDEDQIRRTLEQWHASHDTIGDALGGDDEGMANLDVGLGDEDNAGGDSGIDAKGDDTPVVKFVNKVLVDAIRKGASDIHFEPYEDDYRVRLRIDGLLKMVARAPVKLNQRIAARLKVMAQLDIAEKRVPQDGRIKLNLSKSKQIDFRVSTLPTLFGEKVVLRILDGSAAKLGIDKLGYEPDQQKLFHDAIHKPYGMVLVTGPTGSGKTVSLYTALGILNDETRNISTAEDPVEIRLPGVNQVQQNNKRGMTFAAALRSFLRQDPDIIMVGEIRDLETAEIAIKAAQTGHMVLSTLHTNDAPQTIARLMNMGIAPYNITSSVTLVIAQRLARRLCGNCKRPANLPEHALLAEGFTQAQLDAGIQLYEAVGCDECTEGYKGRTGIYQVMPMTDEIATIVLAGGNALQIAEAAQQIGVNDLRQSALKKAAAGVTSLAEINRVTKD
>NZ_CP040438.1|WP_154264256.1|3738036_3739581_-|FAD-dependent-oxidoreductase
MSKHVVIIGAGPAGLTAALELVGQPGIQVTVLEADDCVGGISRTVNHNGNRIDIGGHRFFSKSDWVMQWWANLMPIEHTGDVPLNLRYQGQAREGLPTGAPVAESSQSTAMLVRNRLSRIYFNRRFFSYPLKLNADSFRNLGVGKSVLFGFSYLRSQVTKIEPELSLEDFLVNRFGQRLYRQFFKEYTEKVWGVPCNQISAEWGAQRIKSLSITKAVLHAARSALGLNGKAEQTSLIENFLYPKHGPGEMWETAAAQFVARGGTLLMKHRAVGLEVGEGLVHSVTVQSGTGEAFKLECSHVVSTMPVRELVSASRKSWPEDVAAIADGLQYRDFITVGLLYDAADLPRALGDNWIYIQEPGVNVGRVQVFNNWSPHMVRDASKVWMGLEFFCRETDPLWNMDDADLQALAQREMLQIGLVTTERAQDAVVIRVPKAYPGYFGEAYAQFDRLRSALDQVQNLFLVGRNGMHRYNNQDHSMLTAKEAADQILSGNVDKSRLWSINVDDEYHEEAKA
>NZ_CP040438.1|WP_154264257.1|3739577_3740042_-|hypothetical-protein
MKPERAARALLLHMQARFAIVAEGTRYLMASAVALCVDLGTFALFSWWWGGWYYAAAGGFLAGSVVAYLISVRWVFARRVVSSASAELAIFVLIGCFGLLVVQGVMWVGIEWLGMPGSIARLVAVGFSFTSNFALRKLILFRSRVRERAIGEVA
>NZ_CP040438.1|WP_154264258.1|3740031_3741969_-|hypothetical-protein
MSTLRRLAPWCFALALVIYLRPYTGIRHDATLYLAQALRLLDPDIFNRDLFFVAGSQADFTLFPQLLASLLRHFQPGDLFLVLSLLGRITFYGASWYLIRALFPPAWRWPSLLALIVMPTRYGAYSIFAYAEPFLTSRPYAEAIALLGLGLLVRRKHMAGILALGAAGILHPLQGFAAVLLAWCWLVLHDRRWLWSLLALVPVIALAAFRVGPFAGLVTAIDYDWWELIYMSSGQIYLGTWEPRDWCIVLADFYFLYLLSRRAQADSLLAQFCAAALAAFAIGMTFSAVLADLLQLVLPVGLQSWRVLWLVHWLAMAGIPYLVWEQWQRTPREWVPVALLVAIALTGASISRITLPWAVLGLIPLHILWPRVTLKVSAPTKAIVLVGLVAVVVAATFRYQMRAWLVFEVFGGDFERVRQDVVILGYPLFAGVLSFGLVWLYGRGPRWGALLGALSIVGLVGSLLLWDSRSPWTRVMEGSHGANVFGVALPRDASVYWYATEPSPLGPWLVLNRANYFSIFQLSGQMFNRGTSMQGIQRQLQVGPVNSQGEICDMVNAVNKDPHACWIGKPGLQYMCSPYRDVPAPDYFVLPFRQQEHVLGRWTPRHPDSGTPLGTFYLYRCSDWAGQGVPESENRLLAPEGLNEA
>NZ_CP040438.1|WP_088479593.1|3742082_3742493_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MKNQKGFTLIELMIVVAIIAILAAIALPAYSDYTKKSKVSEVVLAASALRTAVAEYASSNNSLPGSGWSGFEAQSSKYVSSVGWNGSVITATAQGIGAGVDTSTITLTASLNSTNGTVGWTCGGSIPAKYRPGSCQ
>NZ_CP040438.1|WP_154264259.1|3742854_3744114_+|type-II-secretion-system-F-family-protein
MSVSRSAIKKEPVARSTMELQPFVWEGTDKRGIKMKGEQLAKNANLVRAELRKQGINPGQVKPKPKPLFGAAGKAVNAKDIAFFSRQMATMMKSGVPIVSALEIIASGHKNPRMKKMVDGIRADIEGGSSLNEAISRHPVQFDELYRNLVRAGESAGVLETVLDTIASYKENIEALKGKIKKALFYPAMVLVVAFLVSTILLVWVVPQFEEVFTSFGADLPAFTKMVVGLSRFMVSWWLPIVIVIVAAVVGTIMAYKRSPKMQHGLDRAILKVPVIGQIMHNSSIARFARTTAVTFKAGVPLVEALGIVAGATGNKVYEEGVLRMRDDVSVGYPVNMAMKQLNLFPHMVIQMTGIGEEAGALDAMLFKVAEYYEQEVNNAVDALSSLLEPMIMVFIGTIVGGMVIAMYLPIFKLGAVVG
>NZ_CP040438.1|WP_032128827.1|3744122_3744986_+|prepilin-peptidase
MAFLDQHPGLGYPAAAALGLLLGSFLNVVILRLPKRLEWQWKRDAREVLEEPDFYEPPPPGIVVEPSHCPHCKHKLSWYENIPLFSWIIQGGKCRHCKAPISLQYPLVEALTSVLVLACVWQFGFGWQGFGAIVLTCFLIALSGIDLRTQLLPDQLTLPLMWLGLIGSIDNLYMPAKPALVGAAVGYLSLWTVWWLFKQLTGKEGMGHGDFKLLAALGAWCGLKGILPIILLSSVLGAIIGSIWLYSRGRDRATPIPFGPYLAIAGWLYFMWGAPLVEQYLVMSGLR
>NZ_CP040438.1|WP_154264260.1|3744997_3745609_+|dephospho-CoA-kinase
MSRYVVGLTGGIASGKSEVTRRFEALGIVVADADLAARAVVAAGSPALARIAERFGADMLLADGSLDRGRLRAHVFADPAERTALEAITHPAIRLLMQQQCEQATSAYAIAAIPLLTEVGGRKAYPWLDRVLLVDAPEAVQHARLMQRDGIDAALADRMIAAQASRAQRLALADDVVVNDGQPEDLQVQVEQLHARYLGLAVG
>NZ_CP040438.1|WP_154264261.1|3745876_3746791_+|transposase
MFGIGIDVSKATLDVAVHGEQFRQFSNDKRGFVRLIRWLKKWPIKQVVLEASGGYERAALDVLHAAGLPMVRINPARARRFAQGTGRAAKTDRLDATVLAQMAHLLPLTRYVPPAPWQQRLSEFAQCRRHLVQMRVSEMQRLRRLVDPDLIAMKQRHISQLSDDLKQLDKAIAEQLEGQPGWKNIGALKGVGPILISTLACELPELGSLGSKAIASLVGLAPMNRESGTWQGQRRISGGRAVVREALYMAALTAIRYEPRLRAFYAGLKAKGKASKVALVAVMRKMLVILNARKRDAEVTPGCP
>NZ_CP040438.1|WP_049481722.1|3746802_3747189_-|hypothetical-protein
MSTRPLFPQLHALIGDAANLLPADVAERVEVLLDDPKDLLPALLARMDGRDAADGQPLDVQGASPAQAAMMAGLSRTLAGLHTLIQLLHAAELAREQGGARQQLNPDVVDGLLLGARELARYARLQLE

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Crispr_ID: NZ_CP040438_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_9

3827569-3827718

Unclear

Consensus_repeat	Method
GCCAACCTTGGTTGGCGCCCCGTGCCGACCAAGGTCGGCACCTACCAAAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040438_9

>merge|NZ_CP040438|9|3827569-3827718|CRISPRCasFinder
GCCAACCTTGGTTGGCGCCCCGTGCCGACCAAGGTCGGCACCTACCAAAGCGTTGGTGGGTGCCAACCTTGGTTGGCACCGATGCTGCCCCGGTAGCCGCCAACCTTGGTTGGCGCCCCGTGCCGACCAAGGTCGGCACCCACCAAAGCG

>NZ_CP040438|9|9|3827569-3827718|CRISPRCasFinder
GCCAACCTTGGTTGGCGCCCCGTGCCGACCAAGGTCGGCACCTACCAAAGCG	TTGGTGGGTGCCAACCTTGGTTGGCACCGATGCTGCCCCGGTAGCC
GCCAACCTTGGTTGGCGCCCCGTGCCGACCAAGGTCGGCACCCACCAAAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_154264297.1\|3822938_3823835_-\|fimbrial-protein	unknown	unknown	gnl\|CDD\|225707
NZ_CP040438.1\|WP_154264984.1\|3828649_3829393_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154264294.1\|3817175_3817625_-\|DUF4381-family-protein	unknown	unknown	gnl\|CDD\|379552
NZ_CP040438.1\|WP_154264299.1\|3829462_3833722_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240612
NZ_CP040438.1\|WP_154264296.1\|3819757_3821731_-\|type-IV-pilus-secretin-PilQ	unknown	unknown	gnl\|CDD\|274173
NZ_CP040438.1\|WP_032127838.1\|3841267_3842545_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|180164
NZ_CP040438.1\|WP_049422629.1\|3817621_3818551_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP040438.1\|WP_049432619.1\|3838406_3838910_-\|fimbrial-protein	unknown	unknown	gnl\|CDD\|367947
NZ_CP040438.1\|WP_154264303.1\|3839243_3839606_-\|NirD/YgiW/YdeI-family-stress-tolerance-protein	unknown	unknown	gnl\|CDD\|225653
NZ_CP040438.1\|WP_154264983.1\|3821752_3822259_-\|fimbrial-protein	unknown	unknown	gnl\|CDD\|377322
NZ_CP040438.1\|WP_049400744.1\|3822285_3822942_-\|type-4a-pilus-biogenesis-protein-PilO	unknown	unknown	gnl\|CDD\|225708
NZ_CP040438.1\|WP_154264304.1\|3839905_3840976_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP040438.1\|WP_154264302.1\|3835635_3838356_-\|usher-protein	unknown	unknown	gnl\|CDD\|185210
NZ_CP040438.1\|WP_154264293.1\|3816174_3817179_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238744
NZ_CP040438.1\|WP_154264301.1\|3834505_3835639_-\|pilin-protein	unknown	unknown	gnl\|CDD\|284778
NZ_CP040438.1\|WP_154264300.1\|3833789_3834488_-\|pilus-assembly-protein	unknown	unknown	gnl\|CDD\|237939
NZ_CP040438.1\|WP_010484061.1\|3823834_3824893_-\|pilus-assembly-protein-PilM	unknown	unknown	gnl\|CDD\|378558
NZ_CP040438.1\|WP_154264295.1\|3818559_3819585_-\|AAA-domain-containing-protein	unknown	unknown	gnl\|CDD\|223786
NZ_CP040438.1\|WP_012511978.1\|3827793_3828438_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154264298.1\|3825112_3827536_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|227342

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_154264297.1\|3822938_3823835_-\|fimbrial-protein	gnl\|CDD\|225707	COG3166, PilN, Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion].	1.71287e-51
NZ_CP040438.1\|WP_154264294.1\|3817175_3817625_-\|DUF4381-family-protein	gnl\|CDD\|379552	pfam14316, DUF4381, Domain of unknown function (DUF4381). This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 158 and 180 amino acids in length.	2.591e-21
NZ_CP040438.1\|WP_154264299.1\|3829462_3833722_-\|hypothetical-protein	gnl\|CDD\|240612	cd12820, LbR_YadA-like, YadA-like, left-handed beta-roll. This group contains the collagen-binding domain virulence factor YadA an adhesion proteins of several Yersinia species, and related cell surface proteins, including Moraxella catarrhalis UspA-like proteins. The collagen-binding portion is found in the hydrophobic N-terminal region. YadA forms a matrix on the bacterial outer membrane, which mediates binding to collagen and epithelial cells. YadA inhibits the complement-activating pathway with the coating of the cell surface with factor H, which impedes C3b molecules. These domains form a left handed beta roll made up of a series of short repeated elements. UspA1 and UspA2 are part of a class of pathogenicity factors that act as cell surface adhesion molecules, in which N-terminal head and neck domains extend from the bacterial outer membrane. The UspA1 head domain of Moraxella catarrhalis, is formed from trimeric left-handed parallel beta-helices of 14-16 amino acid repeats. The UspA1 head domain connects to a neck region of large extended, charged loops that maybe be ligand binding, which is in turn connected to an extended coiled coil domain that tethers the head and neck region to the cell surface via a transmembrane region.	1.01831e-12
NZ_CP040438.1\|WP_154264296.1\|3819757_3821731_-\|type-IV-pilus-secretin-PilQ	gnl\|CDD\|274173	TIGR02515, Putative_DNA_transport_protein_HofQ, type IV pilus secretin (or competence protein) PilQ. A number of proteins homologous to PilQ are involved in type IV pilus formation, competence for transformation, type III secretion, and type II secretion (also called the main terminal branch of the general secretion pathway). Members of this family include PilQ itself, which is a component of the type IV pilus structure, from a number of species. In Haemophilus influenzae, the member of this family is associated with competence for transformation with exogenous DNA rather than with formation of a type IV pilus; the surface structure required for competence may be considered an unusual, incomplete type IV pilus structure. [Cell envelope, Surface structures].	0
NZ_CP040438.1\|WP_032127838.1\|3841267_3842545_-\|citrate-synthase	gnl\|CDD\|180164	PRK05614, gltA, citrate synthase.	0
NZ_CP040438.1\|WP_049422629.1\|3817621_3818551_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	3.92667e-23
NZ_CP040438.1\|WP_049432619.1\|3838406_3838910_-\|fimbrial-protein	gnl\|CDD\|367947	pfam04449, Fimbrial_CS1, CS1 type fimbrial major subunit. Fimbriae, also known as pili, form filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometres. They enable the cell to colonise host epithelia. This family constitutes the major subunits of CS1 like pili, including CS2 and CFA1 from Escherichia coli, and also the Cable type II pilin major subunit from Burkholderia cepacia. The major subunit of CS1 pili is called CooA. Periplasmic CooA is mostly complexed with the assembly protein CooB. In addition, a small pool of CooA multimers, and CooA-CooD complexes exists, but the functional significance is unknown. A member of this family has also been identified in Salmonella typhi and Salmonella enterica.	1.13955e-31
NZ_CP040438.1\|WP_154264303.1\|3839243_3839606_-\|NirD/YgiW/YdeI-family-stress-tolerance-protein	gnl\|CDD\|225653	COG3111, COG3111, Periplasmic protein with OB-fold [Function unknown].	2.45716e-26
NZ_CP040438.1\|WP_154264983.1\|3821752_3822259_-\|fimbrial-protein	gnl\|CDD\|377322	pfam04351, PilP, Pilus assembly protein, PilP. The PilP family are periplasmic proteins involved in the biogenesis of type IV pili.	1.43085e-65
NZ_CP040438.1\|WP_049400744.1\|3822285_3822942_-\|type-4a-pilus-biogenesis-protein-PilO	gnl\|CDD\|225708	COG3167, PilO, Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion].	1.58454e-76
NZ_CP040438.1\|WP_154264304.1\|3839905_3840976_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.000254243
NZ_CP040438.1\|WP_154264302.1\|3835635_3838356_-\|usher-protein	gnl\|CDD\|185210	PRK15310, PRK15310, fimbrial outer membrane usher protein TcfC; Provisional.	0
NZ_CP040438.1\|WP_154264293.1\|3816174_3817179_-\|VWA-domain-containing-protein	gnl\|CDD\|238744	cd01467, vWA_BatA_type, VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.	5.85793e-76
NZ_CP040438.1\|WP_154264301.1\|3834505_3835639_-\|pilin-protein	gnl\|CDD\|284778	pfam07434, CblD, CblD like pilus biogenesis initiator. This family consists of several minor pilin proteins including CblD from Burkholderia cepacia which is known to CblD be the initiator of pilus biogenesis. The family also contains a variety of Enterobacterial minor pilin proteins.	2.52374e-37
NZ_CP040438.1\|WP_154264300.1\|3833789_3834488_-\|pilus-assembly-protein	gnl\|CDD\|237939	PRK15308, PRK15308, fimbrial protein TcfA.	8.86269e-48
NZ_CP040438.1\|WP_010484061.1\|3823834_3824893_-\|pilus-assembly-protein-PilM	gnl\|CDD\|378558	pfam11104, PilM_2, Type IV pilus assembly protein PilM;. The type IV pilus assembly protein PilM is required for competency and pilus biogenesis. It binds to PilN and ATP.	4.36463e-170
NZ_CP040438.1\|WP_154264295.1\|3818559_3819585_-\|AAA-domain-containing-protein	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.83917e-90
NZ_CP040438.1\|WP_154264298.1\|3825112_3827536_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|227342	COG5009, MrcA, Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane].	0

>NZ_CP040438.1|WP_154264298.1|3825112_3827536_+|PBP1A-family-penicillin-binding-protein
MTRLRRWLRWIFLIVLVLALIGAAAVGGLYYAVSSKLPDVQTLRDVEMQEPMYVYAADGKLMAVFGETRRTPITMKDVPERLKQAFLATEDARFYEHGGVDYMGIGRAVWLLATTNDKRVPGGSTITQQVARQFFLSSEYSYTRKLAEILLARKIESELSKDEIFELYLNKSFFGNRAYGVAAAAEFYYGKKLNELDLDEMASLAGIPKFPSSGNPISNPERARQRRDNYVLQRMADLKFVSQAEADAAKAVPMHATAHEPPVQVDAPYVAELVRQEMIARFGGDVVNKGYHVTTTIDATLQASANLAVRDGLLLYDHRHGWHGVEKQVQVGAGEDAAALAEHLRGMFGQAGLLPAIVASTGADGSATVVLANRSEIVLPAGAAKWTNKTPGKLVQRGDIVRVRAGAKEGEWLLDQIPRGQSALVSLDAHNGALKALVGGFSFSGNKFNRATQARRQPGSSFKPFVYAAAFDKGYNPASIVLDAPVVFRDRRGKTWAPQNDGGGFRGPMRLREALVQSRNLVSVRLLDGMGVDYARKYISEFGFAESELPPNLSMSLGTASLTPLSVARGYAVFANGGSRVDTWLIDQVNDRDGNLVFKENPALACRDCAGSSDQPVNQVVDGFNFGAPAPKVDPAAAAKAEAKTETPAAPVNPDARTAPRAIDARTAYQLVSMMRDVVQRGTGAQAKVLGREDVGGKTGSTNDHRDAWFSGFGGPYVTTVWVGRDDFRSLGYREYGGKAALPIWIDYMRTALKDTPIAQNDPPSGMVQATLNGATEWVKVEDMDRLTDYDLNLNTPQADAAAFDIF
>NZ_CP040438.1|WP_010484061.1|3823834_3824893_-|pilus-assembly-protein-PilM
MGLIPKSQSPLVGVDISSTAVKLLQLSRSGNRFRVEHYAVEPLPPNAVVEKNIVEVEAVGEAIRRAMNRSGSKAKLAAAAVAGSAVITKVIPMPAELDENDMEAQIELEAVNYIPYPIEEVNLDFEVIGAIPNNPEMVQVLLAASRSENVELRQSALELGGLQAKVMDVEAFAVENAYALVASELPVSIEGVVALVDIGATMTTLNVLRGGRSLYSREQVFGGKQLTDEIMRRYGLSYEEAGLAKRQGGLPESYEMEVLEPFKEATVQQISRLLQFFYAGSEFNRVDHIVLAGGCAVLGGLPEMVEEQLGVPTVVANPLAQMTLGPKVNAHALAQDAPALMIATGLALRSFD
>NZ_CP040438.1|WP_154264297.1|3822938_3823835_-|fimbrial-protein
MARINLLPWRAERRKQRQREFYAMLGMAAMGGLLLSLVIWFYYDRQVSGQMDRNAYLEAEIEKVKEQNKEIDRLDAQKERLLARKKVIEELQAKRSQMVHLFDALVRTIPDGLVLTALKQEGDVLTLEGRTQSNARVSAYMRNLETSGWMTNPELSIIEARDPEKDKDGKVGPLADIKALPYVFVVKVKLPAQSEEVAGTPGLNADGSVATPAPPAVAPLAAGPDAAAPAAPAAGQPAAAPAAPAPAAAPVNAPAATPAPATPNQPAAPAAKPAPKPEGSRLAQPPQAFNAPLQGDRA
>NZ_CP040438.1|WP_049400744.1|3822285_3822942_-|type-4a-pilus-biogenesis-protein-PilO
MSQKIDLKNLDFNDIGNWPQKAKIVFCSLLALVIMFVAWMLLISGKREELAGLESKEVELRSEFTKQQERAVNLAPLKQQLAQMEQVLQQMLRQLPSKTEMPDLIIDISQTALSSGLTNELFEPEQEQVKEFYAEKPIKLRMVGSYHQFGAFVSGVASLPRVVILTMHDINLKPKDKTSGNARSGALELSGTVKTYRYLDETEVQAQQAADAGKEEKK
>NZ_CP040438.1|WP_154264983.1|3821752_3822259_-|fimbrial-protein
MAAVVLMLAGCGRDVTSTPGDAPNLEKWVEGERARPAQPLEPLPVMQQFETFEYSAQGLRDPFTDAWTNPQQGNGGLRPDPNRRKEPLEGFPLDALDMVGTIGTGAATVALVMGPDKVTYRVRPGGYLGQSDGRVTAVFEDHVELIELVPDGAGGWLERPATLSLEDQ
>NZ_CP040438.1|WP_154264296.1|3819757_3821731_-|type-IV-pilus-secretin-PilQ
MTFHQAKGLRPIRRFTLNRVSALGVALMLACAPALAAAPAEKPVGATVAPAAAPAGLSVAKIDFKRGDDGAGRLIVQFDGQGAVPDLRTQGNSVVVDVGNARLPANLQKPMNVIDFATPVQRIDAKPSGAGTQLVLSTGGAVESLAYQSGNEYVVEISPRQAPAAVGAVTAGSVTQAAKAVGQRGFTGKPVTFNFQDVPVRTVLQLIAEESNLNVVASDSVQGNVTLRLVNVPWDQALDIVLRAKGLDKRRDGSVIWVAPQAELAKFEQEKEDARIAIENREDLVTDYVQINYHSATQIFKALTEAKGIGGGSGGGNGGGGGSSQEESGFLSGRGRIVADERTNTLMISDIPKKIARMRELISVIDRPVDQVLIESRIVIATDTFARELGAKFGISGSRDNVYFSGNLDSNAETRKSQVDTALANAKAVREWQAGGSVGPAPIPSGPTIKRGLNWNLPVAAASNPGSLALSILNAGYLLDVELSAMQEESRGEVISNPRVVTTNQREAMIKQGKEIGYVTISGTGAAGGAGSTPNVQFKEVVLELRVTPTITNDNRVFLNMQVKKDEVDQLIELDGYGTVPSINRREVTTAVLVEDGQTVVIGGVYEFTDRSSISKVPFLGDVPFLGNLFKKRGRNKDKAELLVFVTPKVLRVAKQN
>NZ_CP040438.1|WP_154264295.1|3818559_3819585_-|AAA-domain-containing-protein
MNLPPPMPETVSPPSAPATSRLHAAFSQLRDALSAEIVGQAALVERLLIALLADGHLLVEGAPGLAKTTAIRALASRLEADFARVQFTPDLLPADLTGTEIWRPQEGRFEFVPGPIFHPILLADEINRAPAKVQSALLEAMGERQVTVGRHTYALPPLFLVMATQNPIEQEGTFPLPEAQLDRFLMHVRIGYPDQAAESEILRLARERARGALGEAAQAPEKLPMQDVFDARREVLDLHMAPALERFLIELVLASRDPSRYDAGLGRRIAWGASPRGSIALERCARARAWLAGRDFVTPDDVRAVAADVLRHRVLPSYEATAEGWDGERLVQELLARVPAP
>NZ_CP040438.1|WP_049422629.1|3817621_3818551_-|DUF58-domain-containing-protein
MTDPSLHHASSVSDGDGLRPQLSELVALRRLAQRPPPPRRGRAGNAGQAPSPLRGRGMEYAESREYVAGDDARHIDWRVTARTGRAHTKLFQAERERVSLIVADTSPALYFGTRVRFKSVQAARAGAVAAWSAQRRGDRIGALRGSDREPPIAPAGGPRGVLRVLDALTRWYAQPPADDLGLERALDHAGRVLRPGARVLVLADPQQAIRIPPARWSALAQHHDLSLVLLVDPLELQPPSAALQFQTLQQRIGLDLRRSEVQAHWQAHFVEPLQDLRRQLGARRVDVQVLSTDAPSDAWLAPSPTEVPA
>NZ_CP040438.1|WP_154264294.1|3817175_3817625_-|DUF4381-family-protein
MSANLPLRDVQVPPAPSWWPPAPGYLMIGGVVLLLLVVAAFFWWQRRRRRQRWLQLFDQELASTADAAAELAAIAGLLRRAARQAQPGSESLRDDAWWQRVDPKGTLPAARRSLLAEGAYRPRVDANDVAALRSWARERYLTMLLERRR
>NZ_CP040438.1|WP_154264293.1|3816174_3817179_-|VWA-domain-containing-protein
MNLLASYWPWPDLQLAWPLALLALPLPLLMRWWKRRADPGAALRVPYAATELEALAGGGRVDVSWLRTLLLWLGWCALCVALARPQQLGEAITPPQEGRQMMLAMDVSGSMGEGDMVLGGQAVDRLTAAKAVLADFLDRRAGDRIGLLIFGDRAYTLTPLTADLASVRDQLRDSVVGLAGRETAIGDAIGLAVKRLRSQPEGQRVLILLTDGVSNAGVLEPLRAAEVARAEGVRIHTVAFGGDGSMRLFGIPISADQDPVDEATLKKIASMTGGQFFRARDTAQLAGIYAELDRLEPIAAKGPSLRPREERYAWALGLALLLGALAWLWPERRR
>NZ_CP040438.1|WP_012511978.1|3827793_3828438_+|hypothetical-protein
MHRARQHAASQTRERRHRLAHEAARLMAEGGIRDYHQAKLKAASRLGIHDDASLPRNTEIEDALREYQRLFSGPQHGNELQRRREAAMRALEFLHGFAPRLAGPVLDGTADANSPVQLHLHSDDPEAVHRFLDEHGIPAESRTRRLRMDRERCLDVPVWVFSAEELTFDLAVLPYDALRQAPLSPVDEKPMRRASVAQLRQVLAEAEITAYIGG
>NZ_CP040438.1|WP_154264984.1|3828649_3829393_-|hypothetical-protein
MYRWVKGIISYRTFYIWRARYRYYTRNLDLWTLMSGLCIAGLLLVLWYMWRMLSVPTPRVHPETAALRIEGVTREAIHRIVLVRHAGSTPGAPFTTPEEVRASTLRTIRVRQVMDSEVVWRLKADMLADIADYIMATGGCFPYDCRRVLDRLDYVRQAGVENAQINAALSTILEVSLDQMPSLEADEHERVKSGWSDGFNDIYYQSWVLRDLQAMHAQMMREYPQRAPAPWLPRLLSDPLRDTRFVW
>NZ_CP040438.1|WP_154264299.1|3829462_3833722_-|hypothetical-protein
MNRIYRRIWCTARQCWVVASELATARGKRAASSGAIVLPVVASTLMAFSAAAENMPVEEDESVEAAAYLSPKGFNSFGAIPLGLGVRREDAMGTAAAPIYTQVALTSDHYYRNSTINGDLLLMLGSRSSMTGNRSVAYGSLITANGDDNTAIGYGVDITRGGYATGVGARAIASGIGTTALGNDARAYSQNSIAIGSGSRTVESHAGVARIAIGGNAFAGSAGYSGAVALGGSARADYNGVAIGHHAKALAVGSVALGLNSEATESNSVSVGSSSTKRRVVNVADARLSTTSSDAVTGKQLHATNQNVTTATNTANAAKTAADQALVNTRLVTQTSASSAVRVGGDNTGTQLDIRNKSNANRKLTGVADATLSTTSTEAVTGKQLHATNTAVTTAQTTATAAKTAADNALGQVTTVAGLVGQVSASGNVRLGAQNTGTVLDVSNRNGAARRISNVANATLSASSTDAVTGQQLHATNTAVTTAQTTATTAKTTADNALGQVTTVVGLVGQVSASGQVRLGAENTGTVLDVSNKNGARRRIQNIANGILGAGSTDAVTGQQLFATNVRLSTVEVRNDAQDLQLVDHADRLADHRVDLDRLRADFDAFEPDLEGVVKFNADRTLVDLEGAVVKGVGPGDISSAASTDAVNGGQLFATNARIEQMEQGSRFLQVGYDEFSEDASAGWLGVAIGDSAESSPTGEGGTAVGSFSKALGINSVALGRASWVVEGATEGFALGASSHVQASGGVALGARSVVEAGADGSVALGHASIADEMNTVSVGTKGRQRRIVNVDRGHAESDVVTVAQLRESLATLGGGASLDASGNIIAPTYAIQGGNHSTVGDALTALDGAVVVTDARVGSLEGKLRSVFQDTGIRADGLNQLTLSGAQGAVLTNLADGRIAAGSRDAVTGSQLHDAKQEIARNRSDLDALRDSQVTGNDLARLSAAETGSVIDYGGATLTGVADGELSAGSKDVVNGGQLYVVNSRIDGIEQYGRYISIWSDNLSEAAISGMMGVALGDGSIAGPDTDGATAIGSYTSAFGKDSLAIGRGANVASDAVRGMAAMVGSNVYAIDGIALGAFSRVMAGAQGSIALGAGSIADEMDVLSLGHAGLKRRIVNVANGRNAQDATTVAQLNATLATLGGGAHIDSNGNIIGPHFTVQGQQQSTLNDALQSLDGAVTTQGSRVEQVETQLRSVFQDTTTRSDGLNQLTLAGAQGMVISNVANGLVAAGSRDAVNGGQLHDVQQQLNGRMDGLEQRIDGQPQARVAANAAGAPEAPTPPAETPTVADAGKAPNATPETPKEPTPQVDTADLEKMLARANEYSDGISREVDRRLDKMDKRFNRMAAMSSAQSAMAMNTAGLNTYNRLGAGVGYSDGESAMAVGYQRVLNEKGSATFSLNGAFTNSGERSMGVGVGIGW
>NZ_CP040438.1|WP_154264300.1|3833789_3834488_-|pilus-assembly-protein
MHPALSCLFTCALLLAVAPAHANLTVHPMRTSVEARKGAQIRVYSQSTTAQYVQATVRRIDDPASTDEQEIEIEPADAAIAITPGKFALAGGGNRLIRVIPLQPVEKETAYRVYFEGVRGPDDAEPDDPATRAAVGMSLIWGALVNVVPANGHVDVRVRGNSLINAGTLRVGLTSVADCDAAGACTAHDVSRSLYPGASLQLPFTPKPGHRLQLRYRLTRDGYREHVQALAL
>NZ_CP040438.1|WP_154264301.1|3834505_3835639_-|pilin-protein
MSPRLWWWLVLFSALVLVVPQAMAQRPPETHPTDEHRDIVMSWDRSAMPGDIVLMPPRTLLAYDHVDLGKRYGELHLTCVSDSSAERGRCPVEGIRDPDLGLRNIALTFVEKRSQMRMDLNVRGGLERALTNRACMGDFWQLGIMAPWSTHVTGCPGANAAGIGAQLALEIPETRKLVAGIWSATLELRANTPDARNLATYTYRFELTITDYDAVSIYLPEFQEATPTVGLNLSYDPIARTVGGRAHLDMCLYDGLGSQSEYLGVTVRDSGTRPPGPTGYSVWHTDGAGGDSQRMDYTVTLDHNGARIPLRNGVEEQLRNIDTARLRLVMLPGMSQPVFCVPTPLTLDTPRVPIDGKRSGAYQGDLKVELRLPTSRP
>NZ_CP040438.1|WP_154264302.1|3835635_3838356_-|usher-protein
MKASAPAVTRLALALALSLSAPLVAARGVPAGFEDLVEGQTEQLDVRLFGRSTGLMPVRVTLDHVQLEAPAEALQALQLPAEAQAALLPALSQPLPRNSHLACRYGGAAAGCGYLDPPEDPTAVRALYDEGEGAVRLFVARQWIPGEPAAQRHHQVSANAENAFLHQQTVNLSGGRDYQALAAQGAGVLGVFERGHLSANWTFSHQRYRNQRTRHDFQLDNAYYRHDIGPEHYLQAGRMDRRNLSSPQGGTFSFSMLPLDRFQGLRIGTTQAYVDSEAAVQATPLTVLLARDARVDAFDGQRLLQTYYLQAGINQIDTRRFPFGNYTVTLRIYEEGVLVRSEEAPFDKGGDWADSSVQWFMQGGRRSERRSDQFDGEMAAMAGVRVPLGRGATVTAGVADLAGFSYGELRVDLRRVFATQEIRASFSGMQGSDGSRGQQHQLSYRRHASWNLYQQRMRGKACEFRDDARDQLGCADSLSASVALPVAGGHAYLAYTRRQTWRQGVGIPGDIDDPLYGLDPLLPPWAPRPSREPQLSRTWQASYNRSERWGDFSASTRVGVWQQHNDGSLRSSRDRGVFLTLTLTRLQQGERGTAQRRYGLDLRQPQHQRPDVTYSVAQSLRQDNDDQFRELSAELRGNNSDRYSATLSGQLQNRIGHTGATVSHYQQRGRDELAYSATHSSGVALGARGLYWGGGLGADAGLAVQVDGTDDLELTGVAAELQVGGLRRQRLKLGDRRLLPVSAYQSHRAEVQDASALDSIASIRVTGVGGARPLFLPPGKLLRMPVPIEVTYTFIGNAHDLAGTPLRGARILNAPVPGTGSNGGFVADFPRREAVLYLLQDDRLLQCPLQVRERRQVVLLVGAVQCEPLNVAQLPADIRQQARVTRLLQEKALVASSQQAAAGGAR
>NZ_CP040438.1|WP_049432619.1|3838406_3838910_-|fimbrial-protein
MHMLKKAALAAALVTASLSANAAETHITVLADVDPTLALLQADGSPLPDAVKLDHAPGRGLIPWSQQVRIYSNDIDKDIEVRLINEPVLIGNAPGTPSVPLSVSLNSRELGLAATDYLAADLFDGALPGASVAMPLQIAQKTPGAIDVADSFQGMVSIAMKQKTTSP
>NZ_CP040438.1|WP_154264303.1|3839243_3839606_-|NirD/YgiW/YdeI-family-stress-tolerance-protein
MNRLLAIALIATPLTLLSPQGFAQYTGPGAGVAASTVADARAQRDDHPVVLRGTLVAKLGHERYQFRDASGQIEVEIDDDDLPPQAIGADTVVELHGKVDTHRFKPTDIDVDRVTVVPAG
>NZ_CP040438.1|WP_154264304.1|3839905_3840976_-|hypothetical-protein
MSTRFDPPERGPLGPDVGTVVAAPIVAPPSESAVSWGAIFAGAAAAAALSLILLILGVGLGLSSVSPWSFEGVSKETFGWSSIGWLTFTALAASGLGGYLAGRLRTKWTQIHGDETYFRDTAHGFVSWAVATLLTAGLLTSAIGGVLGTGAKVAGATAGAAVSTAGVAAASAGSAAAAAPEGDLNYWVDSLFRSATSAGPSDPATPPPPGAPMDPNAAPPPPVASVGPRDARMAAPPRPMPGNGPVADRREVRAEVNRIIVNSLQGDGLDPADTQYLSQLIARETGMSQAEAQARVTDVQTRMRAALEKAKNTAKQAADDARKAAAYAALWLFITLLIGAFFASLSATWGGRRRDL
>NZ_CP040438.1|WP_032127838.1|3841267_3842545_-|citrate-synthase
MSDLDQVTLNAGDKSVVLPVIKPTLGNDCVDIAKLTKETGYFTYDSGFTATASCKSAITYIDGDKGVLLYRGYPIEQLSEKSSYVEVAYLLINGERPSAEQLKAFTDELAAEANVDESINTLIGSFAKDAHPMAILTAAIAQLSGIYHASLDLSDAEQRRQAAVRLIAKVPTLSALIYRHGKGLPANKPDTSLDYVSRFLKQTFESADGQYDLNPDVVKALDLLFILHADHEQNASTSTVRLVGSTGANPYASVAAGVTALWGPAHGGANEAVLKMLEEIGSADNVESAVVKAKDKTSGFRLMGFGHRVYKNFDPRAKVIGEMTSKVLKQLGVQDPLLDVAVKLEQAALQDEYFVARKLYPNVDFYSGIIYKALQIPTEMFTVMFALGRTSGWVSHWLEQQVDPEMKIGRPRQVYTGSDVRDYQG

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Crispr_ID: NZ_CP040438_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_10

3841088-3841202

Unclear

Consensus_repeat	Method
AGCGTGCCAACCAACGTTGGCACCTACC	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP040438_10

>merge|NZ_CP040438|10|3841088-3841202|CRISPRCasFinder
AGCGTGCCAACCAACGTTGGCACCTACCGAAGGCGGATGCGGTGGTAGATCCACGCCATGCGTGGATGATTTTTCACGGGCGCCGAAAGCGTGCCAACCAAGGTTGGCACCTACC

>NZ_CP040438|10|10|3841088-3841202|CRISPRCasFinder
AGCGTGCCAACCAACGTTGGCACCTACC	GAAGGCGGATGCGGTGGTAGATCCACGCCATGCGTGGATGATTTTTCACGGGCGCCGAA
AGCGTGCCAACCAAGGTTGGCACCTACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_154264984.1\|3828649_3829393_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_049457374.1\|3843172_3844111_-\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239115
NZ_CP040438.1\|WP_154264299.1\|3829462_3833722_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240612
NZ_CP040438.1\|WP_032127838.1\|3841267_3842545_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|180164
NZ_CP040438.1\|WP_154264303.1\|3839243_3839606_-\|NirD/YgiW/YdeI-family-stress-tolerance-protein	unknown	unknown	gnl\|CDD\|225653
NZ_CP040438.1\|WP_049432619.1\|3838406_3838910_-\|fimbrial-protein	unknown	unknown	gnl\|CDD\|367947
NZ_CP040438.1\|WP_005410871.1\|3842841_3843084_-\|type-B-50S-ribosomal-protein-L31	unknown	unknown	gnl\|CDD\|234969
NZ_CP040438.1\|WP_019661980.1\|3847291_3849454_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NZ_CP040438.1\|WP_154264298.1\|3825112_3827536_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|227342
NZ_CP040438.1\|WP_154264308.1\|3854005_3854923_+\|formate-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|273705
NZ_CP040438.1\|WP_154264304.1\|3839905_3840976_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP040438.1\|WP_154264302.1\|3835635_3838356_-\|usher-protein	unknown	unknown	gnl\|CDD\|185210
NZ_CP040438.1\|WP_154264306.1\|3849970_3850636_-\|guanylate-kinase	unknown	unknown	gnl\|CDD\|234719
NZ_CP040438.1\|WP_049461736.1\|3846724_3847111_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|129116
NZ_CP040438.1\|WP_154264307.1\|3850926_3853995_+\|formate-dehydrogenase-N-subunit-alpha	unknown	unknown	gnl\|CDD\|273689
NZ_CP040438.1\|WP_154264301.1\|3834505_3835639_-\|pilin-protein	unknown	unknown	gnl\|CDD\|284778
NZ_CP040438.1\|WP_154264300.1\|3833789_3834488_-\|pilus-assembly-protein	unknown	unknown	gnl\|CDD\|237939
NZ_CP040438.1\|WP_154264305.1\|3844605_3846717_-\|ATP-dependent-DNA-helicase-RecG	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236794
NZ_CP040438.1\|WP_012511978.1\|3827793_3828438_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_005410877.1\|3849560_3849860_-\|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl\|CDD\|234744

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_049457374.1\|3843172_3844111_-\|nucleoside-hydrolase	gnl\|CDD\|239115	cd02649, nuc_hydro_CeIAG, nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal proteins similar to the purine-preferring nucleoside hydrolase (IAG-NH) from C. elegans and the salivary purine nucleosidase from Aedes aegypti. C. elegans IAG-NH exhibits a high affinity for the substrate analogue p-nitrophenylriboside (p-NPR). .	5.96387e-120
NZ_CP040438.1\|WP_154264299.1\|3829462_3833722_-\|hypothetical-protein	gnl\|CDD\|240612	cd12820, LbR_YadA-like, YadA-like, left-handed beta-roll. This group contains the collagen-binding domain virulence factor YadA an adhesion proteins of several Yersinia species, and related cell surface proteins, including Moraxella catarrhalis UspA-like proteins. The collagen-binding portion is found in the hydrophobic N-terminal region. YadA forms a matrix on the bacterial outer membrane, which mediates binding to collagen and epithelial cells. YadA inhibits the complement-activating pathway with the coating of the cell surface with factor H, which impedes C3b molecules. These domains form a left handed beta roll made up of a series of short repeated elements. UspA1 and UspA2 are part of a class of pathogenicity factors that act as cell surface adhesion molecules, in which N-terminal head and neck domains extend from the bacterial outer membrane. The UspA1 head domain of Moraxella catarrhalis, is formed from trimeric left-handed parallel beta-helices of 14-16 amino acid repeats. The UspA1 head domain connects to a neck region of large extended, charged loops that maybe be ligand binding, which is in turn connected to an extended coiled coil domain that tethers the head and neck region to the cell surface via a transmembrane region.	1.01831e-12
NZ_CP040438.1\|WP_032127838.1\|3841267_3842545_-\|citrate-synthase	gnl\|CDD\|180164	PRK05614, gltA, citrate synthase.	0
NZ_CP040438.1\|WP_154264303.1\|3839243_3839606_-\|NirD/YgiW/YdeI-family-stress-tolerance-protein	gnl\|CDD\|225653	COG3111, COG3111, Periplasmic protein with OB-fold [Function unknown].	2.45716e-26
NZ_CP040438.1\|WP_049432619.1\|3838406_3838910_-\|fimbrial-protein	gnl\|CDD\|367947	pfam04449, Fimbrial_CS1, CS1 type fimbrial major subunit. Fimbriae, also known as pili, form filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometres. They enable the cell to colonise host epithelia. This family constitutes the major subunits of CS1 like pili, including CS2 and CFA1 from Escherichia coli, and also the Cable type II pilin major subunit from Burkholderia cepacia. The major subunit of CS1 pili is called CooA. Periplasmic CooA is mostly complexed with the assembly protein CooB. In addition, a small pool of CooA multimers, and CooA-CooD complexes exists, but the functional significance is unknown. A member of this family has also been identified in Salmonella typhi and Salmonella enterica.	1.13955e-31
NZ_CP040438.1\|WP_005410871.1\|3842841_3843084_-\|type-B-50S-ribosomal-protein-L31	gnl\|CDD\|234969	PRK01678, rpmE2, type B 50S ribosomal protein L31.	3.97798e-51
NZ_CP040438.1\|WP_019661980.1\|3847291_3849454_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NZ_CP040438.1\|WP_154264308.1\|3854005_3854923_+\|formate-dehydrogenase-subunit-beta	gnl\|CDD\|273705	TIGR01582, Formate_dehydrogenase_iron-sulfur_subunit, formate dehydrogenase, beta subunit, Fe-S containing. This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport].	6.7588e-157
NZ_CP040438.1\|WP_154264304.1\|3839905_3840976_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.000254243
NZ_CP040438.1\|WP_154264302.1\|3835635_3838356_-\|usher-protein	gnl\|CDD\|185210	PRK15310, PRK15310, fimbrial outer membrane usher protein TcfC; Provisional.	0
NZ_CP040438.1\|WP_154264306.1\|3849970_3850636_-\|guanylate-kinase	gnl\|CDD\|234719	PRK00300, gmk, guanylate kinase; Provisional.	6.43874e-120
NZ_CP040438.1\|WP_049461736.1\|3846724_3847111_-\|RidA-family-protein	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	1.91579e-58
NZ_CP040438.1\|WP_154264307.1\|3850926_3853995_+\|formate-dehydrogenase-N-subunit-alpha	gnl\|CDD\|273689	TIGR01553, Formate_dehydrogenase_major_subunit, formate dehydrogenase-N alpha subunit. This model describes a subset of formate dehydrogenase alpha chains found mainly in proteobacteria but also in Aquifex. The alpha chain contains domains for molybdopterin dinucleotide binding and molybdopterin oxidoreductase (pfam01568 and pfam00384, respectively). The holo-enzyme also contains beta and gamma subunits of 32 and 20 kDa. The enzyme catalyzes the oxidation of formate (produced from pyruvate during anaerobic growth) to carbon dioxide with the concomitant release of two electrons and two protons. The electrons are utilized mainly in the nitrate respiration by nitrate reductase. In E. coli and Salmonella, there are two forms of the formate dehydrogenase, one induced by nitrate which is strictly anaerobic (fdn), and one incuced during the transition from aerobic to anaerobic growth (fdo). This subunit is one of only three proteins in E. coli which contain selenocysteine. This model is well-defined, with a large, unpopulated trusted/noise gap. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport].	0
NZ_CP040438.1\|WP_154264301.1\|3834505_3835639_-\|pilin-protein	gnl\|CDD\|284778	pfam07434, CblD, CblD like pilus biogenesis initiator. This family consists of several minor pilin proteins including CblD from Burkholderia cepacia which is known to CblD be the initiator of pilus biogenesis. The family also contains a variety of Enterobacterial minor pilin proteins.	2.52374e-37
NZ_CP040438.1\|WP_154264300.1\|3833789_3834488_-\|pilus-assembly-protein	gnl\|CDD\|237939	PRK15308, PRK15308, fimbrial protein TcfA.	8.86269e-48
NZ_CP040438.1\|WP_154264305.1\|3844605_3846717_-\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NZ_CP040438.1\|WP_154264298.1\|3825112_3827536_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|227342	COG5009, MrcA, Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane].	0
NZ_CP040438.1\|WP_005410877.1\|3849560_3849860_-\|DNA-directed-RNA-polymerase-subunit-omega	gnl\|CDD\|234744	PRK00392, rpoZ, DNA-directed RNA polymerase subunit omega; Reviewed.	1.39874e-21

>NZ_CP040438.1|WP_154264304.1|3839905_3840976_-|hypothetical-protein
MSTRFDPPERGPLGPDVGTVVAAPIVAPPSESAVSWGAIFAGAAAAAALSLILLILGVGLGLSSVSPWSFEGVSKETFGWSSIGWLTFTALAASGLGGYLAGRLRTKWTQIHGDETYFRDTAHGFVSWAVATLLTAGLLTSAIGGVLGTGAKVAGATAGAAVSTAGVAAASAGSAAAAAPEGDLNYWVDSLFRSATSAGPSDPATPPPPGAPMDPNAAPPPPVASVGPRDARMAAPPRPMPGNGPVADRREVRAEVNRIIVNSLQGDGLDPADTQYLSQLIARETGMSQAEAQARVTDVQTRMRAALEKAKNTAKQAADDARKAAAYAALWLFITLLIGAFFASLSATWGGRRRDL
>NZ_CP040438.1|WP_154264303.1|3839243_3839606_-|NirD/YgiW/YdeI-family-stress-tolerance-protein
MNRLLAIALIATPLTLLSPQGFAQYTGPGAGVAASTVADARAQRDDHPVVLRGTLVAKLGHERYQFRDASGQIEVEIDDDDLPPQAIGADTVVELHGKVDTHRFKPTDIDVDRVTVVPAG
>NZ_CP040438.1|WP_049432619.1|3838406_3838910_-|fimbrial-protein
MHMLKKAALAAALVTASLSANAAETHITVLADVDPTLALLQADGSPLPDAVKLDHAPGRGLIPWSQQVRIYSNDIDKDIEVRLINEPVLIGNAPGTPSVPLSVSLNSRELGLAATDYLAADLFDGALPGASVAMPLQIAQKTPGAIDVADSFQGMVSIAMKQKTTSP
>NZ_CP040438.1|WP_154264302.1|3835635_3838356_-|usher-protein
MKASAPAVTRLALALALSLSAPLVAARGVPAGFEDLVEGQTEQLDVRLFGRSTGLMPVRVTLDHVQLEAPAEALQALQLPAEAQAALLPALSQPLPRNSHLACRYGGAAAGCGYLDPPEDPTAVRALYDEGEGAVRLFVARQWIPGEPAAQRHHQVSANAENAFLHQQTVNLSGGRDYQALAAQGAGVLGVFERGHLSANWTFSHQRYRNQRTRHDFQLDNAYYRHDIGPEHYLQAGRMDRRNLSSPQGGTFSFSMLPLDRFQGLRIGTTQAYVDSEAAVQATPLTVLLARDARVDAFDGQRLLQTYYLQAGINQIDTRRFPFGNYTVTLRIYEEGVLVRSEEAPFDKGGDWADSSVQWFMQGGRRSERRSDQFDGEMAAMAGVRVPLGRGATVTAGVADLAGFSYGELRVDLRRVFATQEIRASFSGMQGSDGSRGQQHQLSYRRHASWNLYQQRMRGKACEFRDDARDQLGCADSLSASVALPVAGGHAYLAYTRRQTWRQGVGIPGDIDDPLYGLDPLLPPWAPRPSREPQLSRTWQASYNRSERWGDFSASTRVGVWQQHNDGSLRSSRDRGVFLTLTLTRLQQGERGTAQRRYGLDLRQPQHQRPDVTYSVAQSLRQDNDDQFRELSAELRGNNSDRYSATLSGQLQNRIGHTGATVSHYQQRGRDELAYSATHSSGVALGARGLYWGGGLGADAGLAVQVDGTDDLELTGVAAELQVGGLRRQRLKLGDRRLLPVSAYQSHRAEVQDASALDSIASIRVTGVGGARPLFLPPGKLLRMPVPIEVTYTFIGNAHDLAGTPLRGARILNAPVPGTGSNGGFVADFPRREAVLYLLQDDRLLQCPLQVRERRQVVLLVGAVQCEPLNVAQLPADIRQQARVTRLLQEKALVASSQQAAAGGAR
>NZ_CP040438.1|WP_154264301.1|3834505_3835639_-|pilin-protein
MSPRLWWWLVLFSALVLVVPQAMAQRPPETHPTDEHRDIVMSWDRSAMPGDIVLMPPRTLLAYDHVDLGKRYGELHLTCVSDSSAERGRCPVEGIRDPDLGLRNIALTFVEKRSQMRMDLNVRGGLERALTNRACMGDFWQLGIMAPWSTHVTGCPGANAAGIGAQLALEIPETRKLVAGIWSATLELRANTPDARNLATYTYRFELTITDYDAVSIYLPEFQEATPTVGLNLSYDPIARTVGGRAHLDMCLYDGLGSQSEYLGVTVRDSGTRPPGPTGYSVWHTDGAGGDSQRMDYTVTLDHNGARIPLRNGVEEQLRNIDTARLRLVMLPGMSQPVFCVPTPLTLDTPRVPIDGKRSGAYQGDLKVELRLPTSRP
>NZ_CP040438.1|WP_154264300.1|3833789_3834488_-|pilus-assembly-protein
MHPALSCLFTCALLLAVAPAHANLTVHPMRTSVEARKGAQIRVYSQSTTAQYVQATVRRIDDPASTDEQEIEIEPADAAIAITPGKFALAGGGNRLIRVIPLQPVEKETAYRVYFEGVRGPDDAEPDDPATRAAVGMSLIWGALVNVVPANGHVDVRVRGNSLINAGTLRVGLTSVADCDAAGACTAHDVSRSLYPGASLQLPFTPKPGHRLQLRYRLTRDGYREHVQALAL
>NZ_CP040438.1|WP_154264299.1|3829462_3833722_-|hypothetical-protein
MNRIYRRIWCTARQCWVVASELATARGKRAASSGAIVLPVVASTLMAFSAAAENMPVEEDESVEAAAYLSPKGFNSFGAIPLGLGVRREDAMGTAAAPIYTQVALTSDHYYRNSTINGDLLLMLGSRSSMTGNRSVAYGSLITANGDDNTAIGYGVDITRGGYATGVGARAIASGIGTTALGNDARAYSQNSIAIGSGSRTVESHAGVARIAIGGNAFAGSAGYSGAVALGGSARADYNGVAIGHHAKALAVGSVALGLNSEATESNSVSVGSSSTKRRVVNVADARLSTTSSDAVTGKQLHATNQNVTTATNTANAAKTAADQALVNTRLVTQTSASSAVRVGGDNTGTQLDIRNKSNANRKLTGVADATLSTTSTEAVTGKQLHATNTAVTTAQTTATAAKTAADNALGQVTTVAGLVGQVSASGNVRLGAQNTGTVLDVSNRNGAARRISNVANATLSASSTDAVTGQQLHATNTAVTTAQTTATTAKTTADNALGQVTTVVGLVGQVSASGQVRLGAENTGTVLDVSNKNGARRRIQNIANGILGAGSTDAVTGQQLFATNVRLSTVEVRNDAQDLQLVDHADRLADHRVDLDRLRADFDAFEPDLEGVVKFNADRTLVDLEGAVVKGVGPGDISSAASTDAVNGGQLFATNARIEQMEQGSRFLQVGYDEFSEDASAGWLGVAIGDSAESSPTGEGGTAVGSFSKALGINSVALGRASWVVEGATEGFALGASSHVQASGGVALGARSVVEAGADGSVALGHASIADEMNTVSVGTKGRQRRIVNVDRGHAESDVVTVAQLRESLATLGGGASLDASGNIIAPTYAIQGGNHSTVGDALTALDGAVVVTDARVGSLEGKLRSVFQDTGIRADGLNQLTLSGAQGAVLTNLADGRIAAGSRDAVTGSQLHDAKQEIARNRSDLDALRDSQVTGNDLARLSAAETGSVIDYGGATLTGVADGELSAGSKDVVNGGQLYVVNSRIDGIEQYGRYISIWSDNLSEAAISGMMGVALGDGSIAGPDTDGATAIGSYTSAFGKDSLAIGRGANVASDAVRGMAAMVGSNVYAIDGIALGAFSRVMAGAQGSIALGAGSIADEMDVLSLGHAGLKRRIVNVANGRNAQDATTVAQLNATLATLGGGAHIDSNGNIIGPHFTVQGQQQSTLNDALQSLDGAVTTQGSRVEQVETQLRSVFQDTTTRSDGLNQLTLAGAQGMVISNVANGLVAAGSRDAVNGGQLHDVQQQLNGRMDGLEQRIDGQPQARVAANAAGAPEAPTPPAETPTVADAGKAPNATPETPKEPTPQVDTADLEKMLARANEYSDGISREVDRRLDKMDKRFNRMAAMSSAQSAMAMNTAGLNTYNRLGAGVGYSDGESAMAVGYQRVLNEKGSATFSLNGAFTNSGERSMGVGVGIGW
>NZ_CP040438.1|WP_154264984.1|3828649_3829393_-|hypothetical-protein
MYRWVKGIISYRTFYIWRARYRYYTRNLDLWTLMSGLCIAGLLLVLWYMWRMLSVPTPRVHPETAALRIEGVTREAIHRIVLVRHAGSTPGAPFTTPEEVRASTLRTIRVRQVMDSEVVWRLKADMLADIADYIMATGGCFPYDCRRVLDRLDYVRQAGVENAQINAALSTILEVSLDQMPSLEADEHERVKSGWSDGFNDIYYQSWVLRDLQAMHAQMMREYPQRAPAPWLPRLLSDPLRDTRFVW
>NZ_CP040438.1|WP_012511978.1|3827793_3828438_+|hypothetical-protein
MHRARQHAASQTRERRHRLAHEAARLMAEGGIRDYHQAKLKAASRLGIHDDASLPRNTEIEDALREYQRLFSGPQHGNELQRRREAAMRALEFLHGFAPRLAGPVLDGTADANSPVQLHLHSDDPEAVHRFLDEHGIPAESRTRRLRMDRERCLDVPVWVFSAEELTFDLAVLPYDALRQAPLSPVDEKPMRRASVAQLRQVLAEAEITAYIGG
>NZ_CP040438.1|WP_154264298.1|3825112_3827536_+|PBP1A-family-penicillin-binding-protein
MTRLRRWLRWIFLIVLVLALIGAAAVGGLYYAVSSKLPDVQTLRDVEMQEPMYVYAADGKLMAVFGETRRTPITMKDVPERLKQAFLATEDARFYEHGGVDYMGIGRAVWLLATTNDKRVPGGSTITQQVARQFFLSSEYSYTRKLAEILLARKIESELSKDEIFELYLNKSFFGNRAYGVAAAAEFYYGKKLNELDLDEMASLAGIPKFPSSGNPISNPERARQRRDNYVLQRMADLKFVSQAEADAAKAVPMHATAHEPPVQVDAPYVAELVRQEMIARFGGDVVNKGYHVTTTIDATLQASANLAVRDGLLLYDHRHGWHGVEKQVQVGAGEDAAALAEHLRGMFGQAGLLPAIVASTGADGSATVVLANRSEIVLPAGAAKWTNKTPGKLVQRGDIVRVRAGAKEGEWLLDQIPRGQSALVSLDAHNGALKALVGGFSFSGNKFNRATQARRQPGSSFKPFVYAAAFDKGYNPASIVLDAPVVFRDRRGKTWAPQNDGGGFRGPMRLREALVQSRNLVSVRLLDGMGVDYARKYISEFGFAESELPPNLSMSLGTASLTPLSVARGYAVFANGGSRVDTWLIDQVNDRDGNLVFKENPALACRDCAGSSDQPVNQVVDGFNFGAPAPKVDPAAAAKAEAKTETPAAPVNPDARTAPRAIDARTAYQLVSMMRDVVQRGTGAQAKVLGREDVGGKTGSTNDHRDAWFSGFGGPYVTTVWVGRDDFRSLGYREYGGKAALPIWIDYMRTALKDTPIAQNDPPSGMVQATLNGATEWVKVEDMDRLTDYDLNLNTPQADAAAFDIF
>NZ_CP040438.1|WP_032127838.1|3841267_3842545_-|citrate-synthase
MSDLDQVTLNAGDKSVVLPVIKPTLGNDCVDIAKLTKETGYFTYDSGFTATASCKSAITYIDGDKGVLLYRGYPIEQLSEKSSYVEVAYLLINGERPSAEQLKAFTDELAAEANVDESINTLIGSFAKDAHPMAILTAAIAQLSGIYHASLDLSDAEQRRQAAVRLIAKVPTLSALIYRHGKGLPANKPDTSLDYVSRFLKQTFESADGQYDLNPDVVKALDLLFILHADHEQNASTSTVRLVGSTGANPYASVAAGVTALWGPAHGGANEAVLKMLEEIGSADNVESAVVKAKDKTSGFRLMGFGHRVYKNFDPRAKVIGEMTSKVLKQLGVQDPLLDVAVKLEQAALQDEYFVARKLYPNVDFYSGIIYKALQIPTEMFTVMFALGRTSGWVSHWLEQQVDPEMKIGRPRQVYTGSDVRDYQG
>NZ_CP040438.1|WP_005410871.1|3842841_3843084_-|type-B-50S-ribosomal-protein-L31
MKADIHPNYRDVVFHDVTSDFKILTRSTMATKETIQWEDGNEYPLVKVEISSASHPFYTGKHKVIDTSGRIDKFQKRYAR
>NZ_CP040438.1|WP_049457374.1|3843172_3844111_-|nucleoside-hydrolase
MTHKIPLLIDTDPGVDDALALLMAFADERHDVVALTIAAGNVGLQYTVRNALKLCDIVGRADVPVFAGSPDPLLHPSVDAAHVHGRDGYGDVDLPPPSRQAEAEHAALAILRLSHEHAGELMLVMLGPLTNLALALKLDPTLPQRIKRIVVMGGAVTCHGNITPAAEFNIAFDPEAAHVVFTSFKHLLVSDWEATVAHGLPLQDAEKWLQADSDRARFYELISRKTRGLSEDSKGGRWYTADAVAMAWALNPEGQLQVESRPLNVELNGTFSRGATIVDWNRQTGQPDNCDLLMAYDQQRFEALVRQALGAD
>NZ_CP040438.1|WP_154264305.1|3844605_3846717_-|ATP-dependent-DNA-helicase-RecG
MARKAAVTPVLSPSGEASLAMLAGVGPAVAAKLQARGLATLQDLWLHLPLRYEDRTRLTRIEDLRNGVPAQVEGRVVAVERGMRYRPMLKVAVEDEGQGTLVLRFFHFRQQQVGQFAVGNRLRCFGTPKPGHLGLEIVHPSYQVLGRNDHPELGDRLDPVYPTVEGVGPMTMRKLISQALDRLPEESTLELLPSGWLDGLGLPSLRSALLTVHRPPPDADLAALAAGTHPAQRRLAMEELLAHHLSLRRQRIALQAHHAPPLAGPGKLAKALLKQLPFALTGAQAHVFKQIREDLARPSPMLRLVQGDVGSGKTVVAALAAMLAVEQGKQVALAAPTELLAEQHLNNLRGWLEPLGVRIAWLAGKVTGKARAKVMEQVANGEAQVVVGTHALMQEAVVFQDLALAIVDEQHRFGVHQRLALRDKGAGGNSVPHQLVMTATPIPRTLAMSEYADLDVSAIDELPPGRTPVQTVALNNDRRPELIERIALACQEGRQVYWVCTLIEESEELDATPAQATYESLQALLPGVRVGLVHGRLKAAEKLATMVAFKAGEIDLLVATTVIEVGVDVPNASLMVIENAERLGLAQLHQLRGRVGRGSAVSRCVLLYQAPLSQMARERLQTMRETNDGFVIAEKDLELRGPGELLGTRQTGLAGFRIADLARDAGLLPGVHDLAERLLAQQPALADRVVQRWIGTAVRYASA
>NZ_CP040438.1|WP_049461736.1|3846724_3847111_-|RidA-family-protein
MSRQIINTEKAPAAIGPYSQAVRAGNTVYFSGQIPLDPATGDVVGAGDVEAQARRAFDNLKAVAEAAGGSLDKVVRLGLYLTDLGEFAKVNAVMQDYFQAPYPARSTIEVSGLPKGANFEVDAVMVID
>NZ_CP040438.1|WP_019661980.1|3847291_3849454_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MNPGPTAKVAAAPAAAVPDYVLQLERAAHYLPPEQLPLLRRAWEVGAAAHAGQTRKSGEPYITHPVAVAQVLAELGLDVEALIAAILHDTIEDTPLTREALAAEFGEAVAELVDGVTKLDKLKFRDRQEAAAESFRKMLLAMSRDLRVIMIKLADRLHNMRTLGAQSREARGRIARETLEIYAPIAQRLGMSLVKSELQNLGFKALYPWRHAILEKHIRSQPVVRREALAQVEVQLSQRLAKEGIEHRLVSRIKTPWSIYNKMRDENKTFDQVMDVFGFRLVVRSVPSCYHALGSVHATFKPLDGRFRDFIAIPKANGYQSLHTVLFGPYGSPIEVQIRTEEMDLIAERGVAAHWTYKFGGDSPNSAQSRAHAWIVELIDSQRAAGSSLEFLDNVKVDLFPDEVYLFTPKGKILALPRNSTALDFAYAVHTDVGNMAVASRVDKKLVPLRTKLVSGQSVEIITARSATPKPQWLEFVVTSKARTAIRHQLKQLEHEDAVQLGHRMLDRALEAMDSSLERLPKGRLDAFLAEHRFPRLEALLAEVALGNWMPTQAAQALMAYAELRGGPHSRHHSQEKILINGSERGVVTFAGCCQPIPGDEIMGYHTAGKGIVVHRMDCPNLAELRKSPERWVPIGWDTTVSGDYDTSLVVEVENGTGVLAQLAAAIAQSHSNIERVDYLDRDFNAAVLAFNIQVRDRNHLAEVMRRLRRLSVVQSVRRQ
>NZ_CP040438.1|WP_005410877.1|3849560_3849860_-|DNA-directed-RNA-polymerase-subunit-omega
MARITVEDCLEVVNNRFELVMMASKRARQLANGVQATLDNSETEDKPTVLALREIAARKIDNALIDEVEKAERERAEREALEWAAAEVVADEDMSKNDD
>NZ_CP040438.1|WP_154264306.1|3849970_3850636_-|guanylate-kinase
MSAPSKPSDAVARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEEMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRMRKRGQDSEAVIAQRLGAARDEMLHFNEFDYVIVNEMFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLTPDSGATD
>NZ_CP040438.1|WP_154264307.1|3850926_3853995_+|formate-dehydrogenase-N-subunit-alpha
MPLMSRRQFLKVTGTTLVGSSLALMGFAPGIALAEVRQYKLTRATETRNTCTYCSVACGILMYSLGDGAKNAEPSIFHIEGDPDHPVNRGTLCPKGAGLADIIHSKSRLLYPEYRAPGSNEWKRLSWDDALDRIARLMKEDRDANFVQKNEAGQTVNRWLTTGMLAASATSNETAVLTHKVVRSLGMLAFDNQARVUHGPTVAGLAPTLGRGAMTNHWVDIKNADLILIMGGNAAEAHPCGFKWVTEAKAHNKARLIVVDPRFNRSAAVADVYAPIRTGTDIVFLGGLINYLLTEDRIQHEYVLNYTDMSFLVKDEFAFKDGLYSGYNEEKRSYDRSSWDYAYGDDGFVRSDPTLKDPHCVYNLLKQHYARYTVEMVERICGTPADSIRQVWEMIASTAGKDKAMTILYALGWTQHSVGAQNVRAGTMVQLLLGNIGVAGGGMNALRGHSNIQGLTDIGLMSDLLPGYLTLPKQDEQDYDAYIAKRTQKPLRANQMSFWQNYPKFHVSLMKSWWGDAATADNNWCFDHLPKLDKPYDMLQAYELMNEGKIHGYICQGFNPLASAPNKGKLISAFSKLKFMVSMDPLETETIAFWQNHGALNDVDPSTIQTEVFRLPTTSFAEENGAVVNSSRWLQWHWKGANPPGEARSDIEIMSELFHRIKALYEKDGGAWWEPVRDLAWKYSNPELPTPEELAMEYNGKALADVFDPKDPTKLVRKAGEQLAAFGDLRDDGSTSSGCWIYIGAWGPTGNMMARRDNSDPTGIGNTLGWAWAWPANRRVMYNRASCDVAGQPFDPRRTLLAWNGKNWGSVDVPDFKADEDPAGGMGPFIMNPEGIARFFAKAGMAEGPFPEHYEPFDTPLRSNPLSPGQALTLNNPAARVFASDRAQIGSPDEFPHVATTYRLTEHFHFWTKHGKLNAIIQPEQFVEIGAALADELGINNGSRVRVSSKRGHIEAVAMVTKRIKALQIDGRTVHQVGVPIHWGFLGAAKPGYIANTLTNAIGDGNSQTPESKCILVKVEKV
>NZ_CP040438.1|WP_154264308.1|3854005_3854923_+|formate-dehydrogenase-subunit-beta
MSLQSLDIIRRSATTTPSPEARGAHTGQVAKLIDVSKCIGCKACQVACMEWNDLRDEVGSCVGSYDNPPDLSEQSWTVMKFREYEDEKGKLEWLIRKEGCMHCSDPGCLKACPSPGAIIQYANGIVDFQEENCIGCGYCVTGCPFDVPRISKKDHKAYKCTLCSDRVAVGQEPACVKTCPTGAITFGSKQAMTEHAAGRVEDLKSRGYENAGLYDPQGVGGTHVMYVLQHVDKPELYADLPKDPRISPMVEVWKGVAKPLGALAIAATAFAGFLHYIGIGRNTVNDEEEEEAEHEAKKIEEEQRP

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Crispr_ID: NZ_CP040438_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_11

4085925-4086111

Orphan

Consensus_repeat	Method
GCGCCTCGGGCGCAGGCCAACCAAGGTTGGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP040438_11

>merge|NZ_CP040438|11|4085925-4086111|CRISPRCasFinder
GCGCCTCGGGCGCAGGCCAACCAAGGTTGGCCTCTACCGGAATGGCGGCGGATGCGGTACGGGCGGCCGGGGCTGCGCCGCGCCTCGGGCGCATGCCAACCAAGGTTGGCTTCTACAGGTAGGTGCCAACCTTGGTTGGCACGGATGTGTCAGCGCCCGGTGCAAGCGTGTGCCAACCAAGGTTGGC

>NZ_CP040438|11|11|4085925-4086111|CRISPRCasFinder
GCGCCTCGGGCGCAGGCCAACCAAGGTTGGC	CTCTACCGGAATGGCGGCGGATGCGGTACGGGCGGCCGGGGCTGCGCC
GCGCCTCGGGCGCATGCCAACCAAGGTTGGC	TTCTACAGGTAGGTGCCAACCTTGGTTGGCACGGATGTGTCAGCGC
CCGGTGCAAGCGTGTGCCAACCAAGGTTGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_154264454.1\|4087620_4087881_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154264451.1\|4083026_4083758_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154264448.1\|4076185_4078261_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_CP040438.1\|WP_154264455.1\|4088345_4088768_+\|low-affinity-iron-permease-family-protein	unknown	unknown	gnl\|CDD\|377225
NZ_CP040438.1\|WP_154264456.1\|4088807_4091921_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|273335
NZ_CP040438.1\|WP_106469147.1\|4075076_4076189_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NZ_CP040438.1\|WP_154264452.1\|4083880_4085806_-\|aminopeptidase	unknown	unknown	gnl\|CDD\|341062
NZ_CP040438.1\|WP_154264459.1\|4094911_4098034_-\|multidrug-efflux-RND-transporter-permease-subunit-SmeE	unknown	unknown	gnl\|CDD\|273335
NZ_CP040438.1\|WP_154264447.1\|4073833_4074928_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NZ_CP040438.1\|WP_154264457.1\|4091933_4093130_-\|multidrug-efflux-RND-transporter-periplasmic-adaptor-subunit-SmeD	unknown	unknown	gnl\|CDD\|184990
NZ_CP040438.1\|WP_154264458.1\|4093400_4094801_-\|multidrug-efflux-RND-transporter-outer-membrane-subunit-SmeF	unknown	unknown	gnl\|CDD\|182103
NZ_CP040438.1\|WP_014038526.1\|4087956_4088283_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_005419402.1\|4080031_4081078_-\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237562
NZ_CP040438.1\|WP_154264460.1\|4098047_4099232_-\|multidrug-efflux-RND-transporter-periplasmic-adaptor-subunit-SmeD	unknown	unknown	gnl\|CDD\|184990
NZ_CP040438.1\|WP_094002387.1\|4086969_4087422_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|238612
NZ_CP040438.1\|WP_154264450.1\|4082403_4083027_-\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_CP040438.1\|WP_154264453.1\|4086128_4086890_-\|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	unknown	unknown	gnl\|CDD\|234689
NZ_CP040438.1\|WP_154264449.1\|4078746_4079910_-\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560
NZ_CP040438.1\|WP_049421386.1\|4081361_4082300_+\|carbohydrate-kinase-family-protein	unknown	unknown	gnl\|CDD\|238917
NZ_CP040438.1\|WP_005419400.1\|4078264_4078750_-\|rod-shape-determining-protein-MreD	unknown	unknown	gnl\|CDD\|225444

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_154264448.1\|4076185_4078261_-\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP040438.1\|WP_154264456.1\|4088807_4091921_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|273335	TIGR00915, Probable_aminoglycoside_efflux_pump, The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family. Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate].	0
NZ_CP040438.1\|WP_106469147.1\|4075076_4076189_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	9.67015e-147
NZ_CP040438.1\|WP_154264452.1\|4083880_4085806_-\|aminopeptidase	gnl\|CDD\|341062	cd09599, M1_LTA4H, Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain. This model represents the N-terminal catalytic domain of leukotriene A4 hydrolase (LTA4H; E.C. 3.3.2.6) and the close homolog cold-active aminopeptidase (Colwellia psychrerythraea-type peptidase; ColAP), both members of the aminopeptidase M1 family. LTA4H is a bifunctional enzyme, possessing an aminopeptidase as well as an epoxide hydrolase activity. The two activities occupy different, but overlapping sites. The activity and physiological relevance of the aminopeptidase is poorly understood while the epoxide hydrolase converts leukotriene A4 (LTA4) into leukotriene B4 (LTB4), a potent chemotaxin that is fundamental to the inflammatory response of mammals. It accepts a variety of substrates, including some opioid, di- and tripeptides, as well as chromogenic aminoacyl-p-nitroanilide derivatives. The aminopeptidase activity of LTA4H is possibly involved in the processing of peptides related to inflammation and host defense. Kinetic analysis shows that LTA4H hydrolyzes arginyl tripeptides with high efficiency and specificity, indicating its function as an arginyl aminopeptidase. Thermodynamic characterization using different biophysical methods shows that structurally distinct inhibitors of the LTA4H occupy different regions of the binding site; while some (RB202, ARM1 and SC57461A) bind to the hydrophobic hydrolase side, both bestatin and captopril are located at the hydrophilic peptidase side. LTB4H overexpression is associated with different pathological conditions and diseases such as cystic fibrosis, coronary heart disease, sepsis, shock, connective tissue disease, and chronic obstructive pulmonary disease. It is also overexpressed in certain human cancers, and has been identified as a functionally important target for mediating anticancer properties of resveratrol, a well-known red wine polyphenolic compound with cancer chemopreventive activity.	0
NZ_CP040438.1\|WP_154264459.1\|4094911_4098034_-\|multidrug-efflux-RND-transporter-permease-subunit-SmeE	gnl\|CDD\|273335	TIGR00915, Probable_aminoglycoside_efflux_pump, The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family. Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate].	0
NZ_CP040438.1\|WP_154264447.1\|4073833_4074928_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	1.5887e-142
NZ_CP040438.1\|WP_154264457.1\|4091933_4093130_-\|multidrug-efflux-RND-transporter-periplasmic-adaptor-subunit-SmeD	gnl\|CDD\|184990	PRK15030, PRK15030, multidrug efflux RND transporter periplasmic adaptor subunit AcrA.	9.33303e-119
NZ_CP040438.1\|WP_154264458.1\|4093400_4094801_-\|multidrug-efflux-RND-transporter-outer-membrane-subunit-SmeF	gnl\|CDD\|182103	PRK09837, PRK09837, Cu(I)/Ag(I) efflux RND transporter outer membrane protein.	2.14655e-118
NZ_CP040438.1\|WP_154264455.1\|4088345_4088768_+\|low-affinity-iron-permease-family-protein	gnl\|CDD\|377225	pfam04120, Iron_permease, Low affinity iron permease.	4.12599e-64
NZ_CP040438.1\|WP_005419402.1\|4080031_4081078_-\|rod-shape-determining-protein	gnl\|CDD\|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0
NZ_CP040438.1\|WP_154264460.1\|4098047_4099232_-\|multidrug-efflux-RND-transporter-periplasmic-adaptor-subunit-SmeD	gnl\|CDD\|184990	PRK15030, PRK15030, multidrug efflux RND transporter periplasmic adaptor subunit AcrA.	2.77965e-116
NZ_CP040438.1\|WP_094002387.1\|4086969_4087422_+\|nucleoside-deaminase	gnl\|CDD\|238612	cd01285, nucleoside_deaminase, Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on the substrate. The functional enzyme is a homodimer. Cytosine deaminase catalyzes the deamination of cytosine to uracil and ammonia and is a member of the pyrimidine salvage pathway. Cytosine deaminase is found in bacteria and fungi but is not present in mammals; for this reason, the enzyme is currently of interest for antimicrobial drug design and gene therapy applications against tumors. Some members of this family are tRNA-specific adenosine deaminases that generate inosine at the first position of their anticodon (position 34) of specific tRNAs; this modification is thought to enlarge the codon recognition capacity during protein synthesis. Other members of the family are guanine deaminases which deaminate guanine to xanthine as part of the utilization of guanine as a nitrogen source.	2.47056e-42
NZ_CP040438.1\|WP_154264450.1\|4082403_4083027_-\|HAD-IA-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	2.15096e-28
NZ_CP040438.1\|WP_154264453.1\|4086128_4086890_-\|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	gnl\|CDD\|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	2.32597e-138
NZ_CP040438.1\|WP_154264449.1\|4078746_4079910_-\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	1.13459e-87
NZ_CP040438.1\|WP_049421386.1\|4081361_4082300_+\|carbohydrate-kinase-family-protein	gnl\|CDD\|238917	cd01942, ribokinase_group_A, Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.	1.14818e-117
NZ_CP040438.1\|WP_005419400.1\|4078264_4078750_-\|rod-shape-determining-protein-MreD	gnl\|CDD\|225444	COG2891, MreD, Cell shape-determining protein [Cell envelope biogenesis, outer membrane].	1.52102e-28

>NZ_CP040438.1|WP_154264452.1|4083880_4085806_-|aminopeptidase
MRNPLMLLPLAVALAAGCSQEAAAPAAPTAAKAPAAPVNAENRSHDESSYAQPDKVVIKDIALDLKLDFDQKQIGGTATYTLEWKQKDARQLVLDTRELTVSKVEAVAADGARSPLKFELAAADKVFGSKLTIEAPEQPAKVEVTYHTAPTASGLQWLAPSMTEGKKLPFMFSQSQAIHARSWVPLQDTPSVRFTYSAHVVSRPDVMVLMSADNDPKAARDGDYTFKMPQPIPSYLLAIAAGDLVFEPISGRSGVWAEPTMVNKAAKEFEDTEKMIGAAEKLYGEYRWGRYDMLVLPPSFPFGGMENPRLTFATPTVIVGDKSLVSLVAHELAHSWSGNLVTNASWKDIWLNEGFTTYVQGRITEALYGKEMAEMEKQIDQTDLLAEVKDMSPADQALALPPLNERDPDEALSQVAYVKGSWFLEFLEQRFGRETFDPFLRGWFDDHAFQSANTDQFVEYLKKNLLPKNPSAVTEAELKAWLDEPGIPAFAAKAQSRNFSSVDTARIAFASAGTVPSSQVIADWSTQEWVRFIDGLGATQPLDKLATLDKAFHFTGTPNGEIAMRWYPLAIRSGYEQANEGAAAFIERVGRRKLIMPIYAELVKTPKGLELAKQAFEKAKPGYHPITTASVQDMLAKAEAK
>NZ_CP040438.1|WP_154264451.1|4083026_4083758_-|hypothetical-protein
MKRLILLTACTLALAACSNPEEERKAQEAAAAAVQAQKEAKAEDVAKQYDMAVAAQDWERARLHGASLLDQYKDTAAAERIAAGFDEVKAKGDAARDLRRMQALWQYNQIPVGNKGNQVSAQIYSKERVDVDGSGAKPVQLVFRDHPEWKRHAYLVLQAGDFRCPQCTVKVTVDDGKPISMAAWRPKTDEAIALFITDQKALWKLARKGKSISIEFPVKAGGTRTAVFETGGVDASSMPQWWQ
>NZ_CP040438.1|WP_154264450.1|4082403_4083027_-|HAD-IA-family-hydrolase
MIATGSAVHALSAIRHWVFDMDGTLTVAVHDFAAIRRALEIAAEEDILDHISALPDAPAQAKREWLLDHERALAEDALPAPGAVTLLRALAEAGCRLGILTRNDHALAKLTLDAIGVGELFDDADIIGRDEAVPKPSPDGLQQHLRRWGIAAAEAVMVGDHAYDLECGRAAGTHTVLVNLSENPWPGSADWHFADCRALLAAWQQKG
>NZ_CP040438.1|WP_049421386.1|4081361_4082300_+|carbohydrate-kinase-family-protein
MSALICGSLAFDTIMVFPDQFKNHILPDKVHILNVSFLVPRMRREFGGCAGNIAYNLHLLGGQPIPMGTVGSDFGPYREYFDGLGIDLSRVRVIDELFTPQAFITTDHDNNQITAFHPGAMMRSYENHVRGVPGVTLGLVGPDGREGMIQNAQEFHEDGIPFIFDPGQAMPLFNGPELREFIEQADYVVVNDYESNLLQERTGWDEKEIVSRVKAYITTRGPKGAVIHTPEKSYDIPPAHERRVVDPTGCGDAFRAGLIYGIQKGYDWLTIGRMGNLMGALKVEHPGTQNQRFTFDEFNEQFKQQFGYALGA
>NZ_CP040438.1|WP_005419402.1|4080031_4081078_-|rod-shape-determining-protein
MFKKLRGMFSNDLSIDLGTANTLIYVRGQGIVLNEPSVVAVRQDRAIGGTRSVAAVGAEAKQMLGRTPGHITTIRPMKDGVIADFTYTEAMLKHFIKKVHKSRVLRPSPRVLVCVPAGSTQVERRAIKESAEEAGARDVFLIEEPMAAAIGAGMPVTEARGSMVIDIGGGTTEVAVISLNGIVYSASVRIGGDRFDESITNYVRRNHGMLIGEATAERIKVELGCAYPQAEVIEMEISGRNLAEGVPKMIKISSNEVLEALHEPLSGIVSAVKLALEQTPPELCADVAERGIVLTGGGALLRDLDRLISEETGLHVQVADDPLTCVARGGGRALELVDMHGNEFFAPE
>NZ_CP040438.1|WP_154264449.1|4078746_4079910_-|rod-shape-determining-protein-MreC
MPPYAGPPVASRSGDAASPLRLLAYLALAITLIVLDDQAGWLAQLRGQANSLVQPVWALAGLPGKLGNQVKDSAASHGQLVNENRELRNQLLLANARLTRLQTAALDNAQLRELLNVAERSGLDVQLAPILDIDLDPVKQRLVLDAGSREGVHVGQAVIDAGGLMGQVISVTGGTSTVLLLTDPDHAVPVTVARNGVRLIVYGRGDKLELRDIPLSAGVEVGDEIVTSGLGGRFPAGFPVGTITGLRPDDTHAFLVGELKPAAQLDRGRDVLLLRPGAAIRLPAASELPQPSLPSANQAAGGASHLTPAPSARPPQQEGGSPPAGSTVVPAAGRQPALSSTKPVAPASSLTPAPSARPPQQEGGSPPADAPVVPAAGRQPITPEAQR
>NZ_CP040438.1|WP_005419400.1|4078264_4078750_-|rod-shape-determining-protein-MreD
MSRLRDNPWVLPASLVVALLLGLLPLPALLQPLRPYWLALVLAYWVIEAPERVGLGIAFASGVVADLLYGGVLGEQALRLVMLAFILQRFRARIRFFPMSQQMLAIGGLLFNDRIVSALVHIVVDEPTLPWSYWWAPLLGMGLWPLVFVLLDAVRFGKRGR
>NZ_CP040438.1|WP_154264448.1|4076185_4078261_-|penicillin-binding-protein-2
MIPRRQVKNPHAEAEQFRRRAALGFLGVLVCLLGLGGWYFKLQVLDHDVYATRSEANRIKPRPVVPGRGMIYDRNGRLLAENVPAFRLDVTPDKVKDMDATLEGLAKIISISPEELEAFNKSRKARRKFLPVTLKLRMSDEEMARFAVDRWRFPGVELEPYLTRRYPYGDLFAHIIGYVGRVDDKDLEILGEGNAALTHIGKSGLERYYEQQLRGKVGYEQVETNVQGRAIRTIGRVAAQSGADLRLSIDADLQRAMVAAFGDQEGSAVAMDPRTGEVLAMVSLPSYDPNLFVNGISHADFKALNDNPSRPQFNRLVLGGVAPGSTLKPLIGLAGLDSGVRRPEDKVLSTGMFYLPGTSRGWGDSHRGGHGWTDLRKSIAQSVNTYYYKLALDLGIERFDHYMEYYGFGQPTGIDLTGEIGGILPSPAYKRKSRKEAWYPGDTVNISIGQGDWKVTPLQLARGVSGLANGQLRTPHLVIQQRAGFDHDWMATDPGESKPISPNPNNLQAVREGMMATMLPGGSAARMAAGAPYTMAGKTGTAQVISRKGTAAVNPKSLPMHLRHRALFVGFAPVEQPVIALAIAVEGGGYGGAAAAPIARKVFDAYLLGKMPEGMQPLDSERGTTAIGATAFDNEDVGARQAGDLAAAQLGEHPVLVGVPAPEPAPAPQPGAPAAAPLPATPRPTTAEPAR
>NZ_CP040438.1|WP_106469147.1|4075076_4076189_-|rod-shape-determining-protein-RodA
MRVFLRWAGDMLRRFFSTLDWVLCLALGALMVIGLATLKSAGGDSLVMAQGVRFAVGMAALWGISRVPILRIRSATPMIYAISMIPLLAVFVLGTGKYGRQWLDLKFFYLQPAELLKVSLPMMVAWYLHKMPLPPRFNTVLVSLVIIGVPTGLVMLQPDFGTGVLIAASGVFVLLLAGLPWWWVGLGVGGVAAVAPVAWFWLLRPYQKDRIMMFLDPEMDALGAGWNIIQSKIAIGSGGFDGKGWGEGSQSHLNFIPEQTTDFAFSVLSEEFGWIGVATVLALYLVVIGRCLWIASQSRDSYSRLLAGATGLAFFVYVLVNGGMISGLLPVVGVPMPLISYGGTSAVSLLAGFGLVMAVRSHNPVHGGYG
>NZ_CP040438.1|WP_154264447.1|4073833_4074928_-|rod-shape-determining-protein-RodA
MEWKRVFGICREAVRTIDLPLLLALLLLMAAGLAVLHSVSGPVAGQAARFAGGLLAMWLLSRVSLLRLRAWTPALYALSLLPLMAVYVIGTGKYGQRWLNLGVFYLQPSELLKLSLPLMMAWYLHRQPLPPSPRTVLTAAVLIGVPAVLILMQPNLGTATLVTASGVFALLLAGLHWGWVATGATGLAVAAPLAWFGLLRQYQKDRVLTFLDPAADPLGTGWNILQSRIAIGSGGWQGRGWGQGTQATLDFLPEYTTDFAFSVLAEEFGWIGVATLFALYLFVVGRCLWIAVHARDTHARLLAGSLGLAFFVYVLVNGGMISGLLPVVGIPMPLISYGGTSAVSLLAGIGLVMAVRGHRPVHGG
>NZ_CP040438.1|WP_154264453.1|4086128_4086890_-|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE
MSESPYKAGTTHFGFRDVAAKDKQKLVGQVFTSVARNYDLMNDLMSLGVHRAWKRYYVATAQVKPGDRVLDLAGGTGDIAALLKERVGAEGSVVLGDINAGMLSVGRDRLTNRGLVLGLDYVQCNAEALPFPDNSFDLVTIAFGLRNVTDKDAGLREMYRVLKVGGQARVLEFSEVTADWFKPIYDFHSFKILPKLGKLFANDSDSYQYLAESIRKHPPQEELKAMMGQAGFERCHYKNLTGGIVSIHSGYKL
>NZ_CP040438.1|WP_094002387.1|4086969_4087422_+|nucleoside-deaminase
MITTPDYQALLQTAIAEARQGLAEGGVPIGAALYHNDGRLLGCGHNRRVQEGDPSVHGETDAFRKAGRQRRYQDTIMVTTLAPCWYCSGLVRQFNIGTVVVGESRTFQGGIDWLRENGVNVIDLDSQECVDLLGGFIAQYPEIWNEDIGE
>NZ_CP040438.1|WP_154264454.1|4087620_4087881_+|hypothetical-protein
MCAHAVRPTPDPILDAIRDRLQQQYTLHQRGALFWTAYQGLQLELVRGRPLDHERLCNAMADIAEDLGAVEHAQLIGNRNAGSTSR
>NZ_CP040438.1|WP_014038526.1|4087956_4088283_+|hypothetical-protein
MHAEVPTIPPVINVDAELDHWRRQHADGALPHNSFGSYVPWIKFACDSLITQPRASNAQRDEMFQTQYALQIMPRLSEAQAREFVDRCWQHVYQTSPVRLQDAPRLRA
>NZ_CP040438.1|WP_154264455.1|4088345_4088768_+|low-affinity-iron-permease-family-protein
MKARNLFNTIAKKAAAATGSPWTFLAAVAIVVLWGISGPVFGFNDTWQLVINTGTTIITFLMVFLIQHTQNADTAAMQIKLDELIRATAEANNELLDLEELDEERLEEIRAEYERMAREAGDALLRVRACRAAPRDDEAV
>NZ_CP040438.1|WP_154264456.1|4088807_4091921_-|efflux-RND-transporter-permease-subunit
MARFFIDRPIFAWVIAIIIMLAGGLALFKLPVEMYPDVAPPTITLTAIHPGASARIIEETVTQIIETQLVGIDGLQYFTSQSYSYAGYSNVTLVFHTGTDLDAALVQVQNRVQQAMPALPEQVRMRGVSAAKASSGFLQIVAFVSTDGALDAADVADFVGSSVVDTLSRVPGVGHVREFAGKYALRIWLDPAKLQAYAVSAEDIAQAVRGRTLQPAFGELGGGPAVNGQPISAYIEGEPSARTAEDVGGIVIRASTDGSELRLRDVARVELGAESYEFSNRLNGRPAAGVGITLAPGANALQTRAAVDQVLEGLSASLPAGVEVVVPYDATPFVRMSIKGVVQTLIEAIVLVFVVMYLFLQNFRATLIPTIAVPVVLLGTFGVLAMLGFSVNMLTMFAMVLAIGLLVDDAIVVVENVERIMSEEGLSPLEATRKSMGQITGALVGIGLVLSAVFVPMAFMSGSTGVIYRQFSATIVSAMALSVLVAIVLTPALCATMLKPLKKGEHHVAHRGLAGRFFNGFNRGFDRTSESYQRGVRGIIHRPWRFMGMVAALFMLMGVLFVRLPSAFLPNEDQGTLVVLVNGVAGSTLQQTTHALQAVEHYFLESDPMAEAMFTVAGYSYSGMGQNAGLAFIRLKDWARRGSADNAEAIALRATRALATQGMADFHVLAPPPIPALGNASGFGFFLKDDAGQGHSHLAQARDTLLAAASQSPLLQQMRANGMEDVAALQVRIDDAKARAHGLTAERIGNELGAGWGGRYVADFLDRGRVKRIIMQADASSRGLPQDFSQWAVRNDQARMVPFDTLGSTHWIQSSPRLERFNGTAAMEIHGQPAPGTSSGEAMREIERLVALLPPGFSIEWTGAASQERDSRSQLPLLYVLSLLMVFLCLAAMYESWIVPVAVLLAAPLGILGAVLANTINGLERDIYFQVAMLTTVGLTSKNAILIIEFAKEHMEHGAGLINAIMHAVRDRLRPIVMTSLAFGMGVIPLAVSSGAGSGAKQAIGIGVLGGMVAGTSLGLLFVPLFFVVVQRAFKRG
>NZ_CP040438.1|WP_154264457.1|4091933_4093130_-|multidrug-efflux-RND-transporter-periplasmic-adaptor-subunit-SmeD
MCLSHSLLCSSRRWLIFVSSILLVACQPSAMGHDPGPMAVQMVTLKSETVGLTRELPGRTNAFLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRLQDNQTLPVSILMEDGSTFEHKGTLEFSEVSVDPATGSFGLRVKVDNPDGLLMPGTYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATEKGAAPAKPAAAAQPAAPAGGAK
>NZ_CP040438.1|WP_154264458.1|4093400_4094801_-|multidrug-efflux-RND-transporter-outer-membrane-subunit-SmeF
MEVIPMKSASLFLSIAAALALAGCSTLVPKNTAVAPAIPAQWPAEAAQGEVADVAAVGWRDFFTDARLQQVIDQSLQNNRDLRVAVLNVERARGQYRVQRADRVPGVAVTGQMDRRGTDAGVTEQFTAGVGVAEFELDLFGRVRNLSEAALQQYFAVAANRRNAQLSLVAETATAWLTYGADAQRLKIADATLKTYEDSLRLAEARHERGGSSALELTQTRTLVETARTDAARLRGQLAQDRNALALLAGGPLDPALLPDSIEPQLLALAPPPAGLPSDVLLQRPDIMAAEHQLLAANANIGAARAAFFPSISLTGSIGSGSSELSNLFDSGTRVWSFLPKITLPIFQGGKLRANLAIANADRDIALAQYEKSIQVGFRETADALALNVSLDEQVSAQQRLVEAAEQANRLSQARYDAGLDSFVTLLDARRTAYTAQQTRLQAELAQQSNRITLYKVLGGGWHERS
>NZ_CP040438.1|WP_154264459.1|4094911_4098034_-|multidrug-efflux-RND-transporter-permease-subunit-SmeE
MARFFIDRPIFAWVIAIIIMLAGGLALFKLPVSMYPNVAPPAVEISATYPGASAKVVEDSVTQIIEQNMKGLDGLIYFSSNSSSNGQATITLTFESGTNPDIAQVQVQNKLQLAMPLLPQEVQRQGINVAKSSSGFLNVIAFVSENGSMDANDIADYVGSNVVDRLSRVPGVGNIQVFGGKYAMRIWLDPNKLHTYGLSVAEVTAAVKAQNAQVAIGQLGGAPSIKGQQLNATINAQSRLQTPEQFRNIIVRGAQDGAELRLGDVARVELGAESYDFVTRYNGQPASGLAVTLATGANALDTAAGVDAALQDMKSFFPAGLKAEIPYDTTPFVRVSIKGVVQTLIEAIVLVFVVMYLFLQNFRATLIPTIAVPVVLLGTFGVLAMLGFSVNMLTMFAMVLAIGLLVDDAIVVVENVERIMSEEGLSPLEATRKSMGQITGALVGIGLVLSAVFVPMAFMSGSTGVIYRQFSATIVSAMALSVLVAIVLTPALCATMLKPLKKGEHHVAHRGLAGRFFNGFNRGFDRTSESYQRGVRGIIHRPWRFMGIVAALFVLMGVLFVRLPSSFLPNEDQGVLMALVQAPVGATQERTLESIAALENHFLQNEKDAVDSVFSVQGFSFAGMGQNAGMAFVKLKDWSERDADNGVMPITGRAMAALGQIKDAFIFAFPPPAIPELGTASGYTFFLKDNSGQGHEALVAARNQLLGLAAGSKKLANVRPNGQEDTPQFRIDIDAAKATSLGLSIDQINGTLAAAWGSSYIDDFVDRGRVKRVFVQADQPFRMVPEDFDLWSVKNDKGEMVPFSAFATKHWDYGSPRLERYNGVSAMEIQGEPAPGVASGDAMAEIEQLAKQLPAGFGIEWTAMSYQERQAGSQTPLLYTLSLMIVFLCLAAMYESWSVPTAVLLAAPLGILGAVLANTFKGLERDIYFQVAMLTTVGLTSKNAILIVEFAKENLEKGASLIESIMHAVRDRLRPIVMTSLAFGMGVVPLAISTGAGSGAKQAIGTGVLGGMIVGTVLGVFFVPLFFVVVQRVFKRKSTT
>NZ_CP040438.1|WP_154264460.1|4098047_4099232_-|multidrug-efflux-RND-transporter-periplasmic-adaptor-subunit-SmeD
MLLSRIRPFALSLAIAATVAACGGQPQAPEQGPGDVTVVTLKSETVGLTRELPGRTNAFLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKAALDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRLQDNQTLPVSILMEDGSTFEHKGTLEFSEVSVDPATGSFGLRVKVDNPDGLLMPGTYVRAVIGGGVRSDAVLVPMAGIARDPKGDTSAMVVDKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATEKGAAPAKPAAAAQPAAPAGDAK

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Crispr_ID: NZ_CP040438_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_12

4394749-4394859

Orphan

Consensus_repeat	Method
GGTAGTGCCGGCCGCTGGCCGGCAACCTCGCGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040438_12

>merge|NZ_CP040438|12|4394749-4394859|CRISPRCasFinder
GGTAGTGCCGGCCGCTGGCCGGCAACCTCGCGAACCTGCAGCCAGGCATGGCCTGGCTCTACTGCCGGTTGCCTGGGGTAGTGTCGGCCGCTGGCCGGCAACCTCGCGAAC

>NZ_CP040438|12|12|4394749-4394859|CRISPRCasFinder
GGTAGTGCCGGCCGCTGGCCGGCAACCTCGCGAAC	CTGCAGCCAGGCATGGCCTGGCTCTACTGCCGGTTGCCTGG
GGTAGTGTCGGCCGCTGGCCGGCAACCTCGCGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_154264658.1\|4402264_4403230_-\|sodium:calcium-antiporter	unknown	unknown	gnl\|CDD\|223604
NZ_CP040438.1\|WP_154264651.1\|4393773_4394706_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NZ_CP040438.1\|WP_154264656.1\|4400491_4400998_+\|Na+/H+-antiporter-subunit-E	unknown	unknown	gnl\|CDD\|181598
NZ_CP040438.1\|WP_014038745.1\|4393308_4393638_-\|DnaJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|236512
NZ_CP040438.1\|WP_154264660.1\|4404085_4404619_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154264648.1\|4390902_4391838_-\|lipid-kinase-YegS	unknown	unknown	gnl\|CDD\|237281
NZ_CP040438.1\|WP_154264645.1\|4386612_4387644_-\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NZ_CP040438.1\|WP_154264654.1\|4398570_4398963_+\|Na+/H+-antiporter-subunit-C	unknown	unknown	gnl\|CDD\|236377
NZ_CP040438.1\|WP_154264646.1\|4388250_4389030_-\|DUF541-domain-containing-protein	unknown	unknown	gnl\|CDD\|377344
NZ_CP040438.1\|WP_154264650.1\|4392603_4393278_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|136958
NZ_CP040438.1\|WP_005411334.1\|4400994_4401279_+\|K+/H+-antiporter-subunit-F	unknown	unknown	gnl\|CDD\|180435
NZ_CP040438.1\|WP_154264652.1\|4394923_4395409_+\|DUF962-domain-containing-protein	unknown	unknown	gnl\|CDD\|226914
NZ_CP040438.1\|WP_154264653.1\|4395742_4398571_+\|monovalent-cation/H+-antiporter-subunit-A	unknown	unknown	gnl\|CDD\|237157
NZ_CP040438.1\|WP_154264655.1\|4398959_4400495_+\|monovalent-cation/H+-antiporter-subunit-D	unknown	unknown	gnl\|CDD\|237166
NZ_CP040438.1\|WP_154264647.1\|4389097_4390573_-\|anthranilate-synthase-component-I	unknown	unknown	gnl\|CDD\|184146
NZ_CP040438.1\|WP_049424046.1\|4387660_4388248_-\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|235552
NZ_CP040438.1\|WP_154264649.1\|4392061_4392544_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP040438.1\|WP_154264657.1\|4401275_4401665_+\|Na+/H+-antiporter-subunit-G	unknown	unknown	gnl\|CDD\|237169
NZ_CP040438.1\|WP_154264644.1\|4385743_4386538_-\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_CP040438.1\|WP_154264659.1\|4403303_4403960_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_154264658.1\|4402264_4403230_-\|sodium:calcium-antiporter	gnl\|CDD\|223604	COG0530, ECM27, Ca2+/Na+ antiporter [Inorganic ion transport and metabolism].	4.60868e-43
NZ_CP040438.1\|WP_154264651.1\|4393773_4394706_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NZ_CP040438.1\|WP_154264656.1\|4400491_4400998_+\|Na+/H+-antiporter-subunit-E	gnl\|CDD\|181598	PRK08965, PRK08965, putative monovalent cation/H+ antiporter subunit E; Reviewed.	3.23374e-62
NZ_CP040438.1\|WP_014038745.1\|4393308_4393638_-\|DnaJ-domain-containing-protein	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	1.53677e-18
NZ_CP040438.1\|WP_154264648.1\|4390902_4391838_-\|lipid-kinase-YegS	gnl\|CDD\|237281	PRK13054, PRK13054, lipid kinase; Reviewed.	2.49659e-157
NZ_CP040438.1\|WP_154264645.1\|4386612_4387644_-\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	0
NZ_CP040438.1\|WP_154264654.1\|4398570_4398963_+\|Na+/H+-antiporter-subunit-C	gnl\|CDD\|236377	PRK09094, PRK09094, putative monovalent cation/H+ antiporter subunit C; Reviewed.	1.61679e-62
NZ_CP040438.1\|WP_154264646.1\|4388250_4389030_-\|DUF541-domain-containing-protein	gnl\|CDD\|377344	pfam04402, SIMPL, Protein of unknown function (DUF541). Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	2.17861e-19
NZ_CP040438.1\|WP_154264650.1\|4392603_4393278_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|136958	PRK08745, PRK08745, ribulose-phosphate 3-epimerase; Provisional.	1.64255e-152
NZ_CP040438.1\|WP_005411334.1\|4400994_4401279_+\|K+/H+-antiporter-subunit-F	gnl\|CDD\|180435	PRK06161, PRK06161, putative monovalent cation/H+ antiporter subunit F; Reviewed.	1.64199e-36
NZ_CP040438.1\|WP_154264652.1\|4394923_4395409_+\|DUF962-domain-containing-protein	gnl\|CDD\|226914	COG4539, COG4539, Predicted membrane protein [Function unknown].	4.04086e-15
NZ_CP040438.1\|WP_154264653.1\|4395742_4398571_+\|monovalent-cation/H+-antiporter-subunit-A	gnl\|CDD\|237157	PRK12648, PRK12648, putative monovalent cation/H+ antiporter subunit A; Reviewed.	0
NZ_CP040438.1\|WP_154264655.1\|4398959_4400495_+\|monovalent-cation/H+-antiporter-subunit-D	gnl\|CDD\|237166	PRK12666, PRK12666, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0
NZ_CP040438.1\|WP_154264647.1\|4389097_4390573_-\|anthranilate-synthase-component-I	gnl\|CDD\|184146	PRK13565, PRK13565, anthranilate synthase component I; Provisional.	0
NZ_CP040438.1\|WP_049424046.1\|4387660_4388248_-\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|235552	PRK05670, PRK05670, anthranilate synthase component II; Provisional.	2.04723e-132
NZ_CP040438.1\|WP_154264649.1\|4392061_4392544_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.8354e-14
NZ_CP040438.1\|WP_154264657.1\|4401275_4401665_+\|Na+/H+-antiporter-subunit-G	gnl\|CDD\|237169	PRK12674, PRK12674, putative monovalent cation/H+ antiporter subunit G; Reviewed.	9.69248e-33
NZ_CP040438.1\|WP_154264644.1\|4385743_4386538_-\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	6.79269e-152

>NZ_CP040438.1|WP_154264651.1|4393773_4394706_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MPVPTTLLQSDLPGLPLRHRGKVRDVFDIPRERLPAGTPPGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAHLMPNHLTGIDVASVLPEGVDPVLYAKRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKVSGIDLPDGLRQAEQLPEPIFTPSTKAAVGDHDENIDFDAMVKQVGADLAERVRDATLRIYKFAADYARERGIILADTKFEFGTDADGRLYIMDEMLTPDSSRYWPADEYEVGTSPPSYDKQFVRDYLETLDWGKTAPGPTIPAEIIERTRAKYAEALQRLAGISVD
>NZ_CP040438.1|WP_014038745.1|4393308_4393638_-|DnaJ-domain-containing-protein
MRWYGKLLGFIAGALLFRPNPLFGAVVGLLIGHAFDSDWFRLNKENPYRELGLTSEATDAEVERAYRRLISQYHPDKLGGAAPELQQQAEQKSRRINAAYDRIKTLRKR
>NZ_CP040438.1|WP_154264650.1|4392603_4393278_-|ribulose-phosphate-3-epimerase
MSNCLIAPSILSANFARLGEEVDNVLAAGADWVHFDVMDNHYVPNLTIGPMVCQALRKHGVTAPIDVHLMVEPVDRIIPDFAEAGATYISFHPEASRHVHRTIQLIRSLGCKPGIVLNPATPVDILDWVLDDLDLVLLMSVNPGFGGQAFIPSALDKLRVVRKMIDASGKDIRLEIDGGVKADNIGEIAAAGADTFVAGSAIFNAKASYQDVIAQMRANVAAAR
>NZ_CP040438.1|WP_154264649.1|4392061_4392544_-|GNAT-family-N-acetyltransferase
MALLNIRPATVADAGLILQFIRELAIYEKAEHSVQTDEIGIAESLFGADATARALICEADGEAIGYAVYFYNYSTWLGRKGIYLEDLYVSQEKRGVGAGKALLKYIARQAVAEGCGRFEWSVLDWNTPAIEFYTAAGATPQDEWTVYRLQGQALHDFANG
>NZ_CP040438.1|WP_154264648.1|4390902_4391838_-|lipid-kinase-YegS
MAAPRWRLILNGKSAGNDELRDAVGHWRGQGVQLEVRVTWEDGDAERYVAEAIDHGVDVIVAAGGDGTLSAVAETLAHREEPADALPSLALIPMGTANDFATAAGIPTEPKAAFALIGQATPHAIDLLGVDADGTQWWCANLASGGFGTQVTVETDAGLKKMLGGLAYVITGIAKLGRIEPIHARLSGPDFAWEGDFIALGIGNGRQAGGGQQLCPQALIDDGLLDVTVLPELEGEVTATLGQMLKSGTQAALEQLATRARLPWLQVESERPLTLNLDGEPVQARQFRIACVPGRVRMHLPAGCPLLGGQG
>NZ_CP040438.1|WP_154264647.1|4389097_4390573_-|anthranilate-synthase-component-I
MNSHAQFQQQAAEGHTHIPVVREVLSDLDTPLSVYLKLADGPNTYLFESVEGGERFGRYSIIGLPARRVYAFHGHTLTVREDGQVVDTREVADPFAEVEALRSAHSVPKLEGLPGFTGGLVGWFGFECIGYIEPRLAPPAGRDELGTPDILLLDSNELAVFDNLKGRLYLIVHADPRVEGAFEQAQARLDALTTKLRAPGAGYPAPLNSDVLDESDFVSGFTREGFVDAVQRSKEYIRAGDIFQVVLSQRLSVPFKARPVDVYRALRALNPSPYMYFLDVGDLQVVGSSPEILVRLQDGEVTVRPIAGTRPRGATPELDQALEAELLADPKERAEHLMLIDLGRNDAGRVSKAGTVEVGEQFVIERYSHVMHIVSEVTGQLQPGLSYADVLRATFPAGTVSGAPKIRALEVIRELEPIKRNVYAGSIGYIGWHGDADTAIAIRTAVIKDGRLYVQAGAGIVYDSDPDKEWDETMNKGRALFRAVAQAAKGL
>NZ_CP040438.1|WP_154264646.1|4388250_4389030_-|DUF541-domain-containing-protein
MKLLSALLWSSLLATMAPSAWAQANTIPSQPHLLVKGQGTRTVMPDRFGLQLNIEETDMDADAARRRVQDNVARALALFRQHKAVDGSVRADNLRIGPATRYEDSRQVFIGTRVSRQLRASFASVKQMQDVLAALKANEHVQVSSMAPTYSGEVALRRELKGEAAASTRESAQGLANAYGTKLRGLYSISDVAPNFAYGVQAGNWPRSDDMVTPPSPPSPAAQMDMIETTGSRLRESIEAGPITYTENVYAIFLISDGT
>NZ_CP040438.1|WP_049424046.1|4387660_4388248_-|aminodeoxychorismate/anthranilate-synthase-component-II
MLWMIDNYDSFTYNLVQYLQTLGAEVKVVRNDAMSVDEIAAQKPERIVISPGPCTPNEAGVSLELIQRLGPTTPILGVCLGHQGIGQVYGGTVIRAGNIMHGKTSPIRHQGKGVFAGLPDRYQATRYHSLVVDKNSLPDVLEVTAWTENDDGSIEEIMGLRHRQFPVEGVQFHPESILTEHGHALLRNFLQRPAA
>NZ_CP040438.1|WP_154264645.1|4386612_4387644_-|anthranilate-phosphoribosyltransferase
MSFSPQEALQRTIEHREIFFDEMVDLMRQIMRGDVSPMMTAAILTGLRVKKETIDEIAAAATVMREFALAVPVADTTHLVDIVGTGGDGSHTFNISTCAMFVAAAAGARVAKHGNRSVSSKSGSADAVEALGAAIELQPTQVAAAIDRTGIGFMFAPIHHPSMKVVAPVRREMGVRTIFNILGPLTNPASAPSVLMGVFHPDLVGIQARVLRELGTERAMVVWGRDNMDEISLGAGTLVGELRDGKVREYEIHPEDFGIAMSASRNLRVDGPEQSIAMLRAVLDNEPGPALDIVALNAGAALYVAGVASDIGDGLARARAAIANGSARQRLQQYVETTRALVA
>NZ_CP040438.1|WP_154264644.1|4385743_4386538_-|indole-3-glycerol-phosphate-synthase-TrpC
MSDILQTILARKAEEVAQRRAQRPLEALQAALASAPPVRGFVSALQAAVANGDPAVIAEVKKASPSKGVIRADFRPADIAVSYEFGGASCLSVLTDVDFFQGADAYLQQAREACTLPVLRKDFVIDAYQVYEARVLGADCILLIVAALDDTQLATLSELAMSLGMDVLVEVHDIDELERALQVPAPMIGINNRNLRTFEVSLQTTLDMQNAVPRDRLLVTESGILGPKDVALMRDAGIHAFLVGEAFMRVEEPGEGLRQLFFAA
>NZ_CP040438.1|WP_154264652.1|4394923_4395409_+|DUF962-domain-containing-protein
MQTTTQLARPIDRYFASYSDDHRNVINQRIHVVAVPAILWSVVALLWCLPPLITWFQYGIWSAFAMFSAWCFYNKLSRPLGIGMLIQFFVFGCLCRLLEAEIGLHNLFWLAVGVFVVAWIAQFIGHKFEGRKPSFLTDLTYLLIGPAWVMAKFYRKLDWRY
>NZ_CP040438.1|WP_154264653.1|4395742_4398571_+|monovalent-cation/H+-antiporter-subunit-A
MLPSLPLLLALPFLMAAAVAAFPRSSRSTAAWLAALAPLGGLAILGWLTPSVLDGQVVRTMVPWLPQIGLDFTLRLDGLAWMFAGLVLGIGALVVLYARYYLSQQDNAHRFYCYLLLFMGAMLGMVLSGNLLLLMIFWEMTSISSFLLIGFWSHRQDAREGARMALVITGGGGLALLGGVLLIGRIVGSFDLDVVLAAGEQIRASALYPYALFLVLAGIFTKSAQFPFHFWLPHAMAAPTPVSAYLHSATMVKAGVFLLARLHPALAGSDLFFYTVSGIGALTLLIGAWNAIFQHDLKGLLAYSTISHLGLITLLFGLSTPMAVVAGVFHILNHATFKASLFMAAGIIDHETGTRDMRKLGGLRRLMPFTSALAIIASLAMAGIPLLNGFLSKEMLFAEAITAGGPGIMRAAVSIAALLAGVFGVAYSLRFVHDTFFGPGPHDLDRVPHEPPRWMKVPVELLVVICIAVGVAPALTVAPVLHAAAASILGPAMPEYSLAVWHGFNLPLAMSAMGVVGGVVLYFGLRKLINLHGVTNVSTGRNVFHAQLDAVSALAMRLTNGIANGSLQRMLLGLVLVAIAVAAAPFVANPASPNWTAPQPIPLLGWALWLVMMSCAVATLRVYKQRLLAVLLVGGVGLMVALTFVFLSAPDLALTQLLVEMVTLVLMLLGMNYLPAQSGPERPRWRKRRDAVIAIIAGAGLGALAYSAMTLPPNTMAGELLARALPEAYGQNVVNVILVDFRGFDTFGEITVFGIAALVVHALLRRTRMAPEQIMPGPPIKLPVPADLAQIMFPLTLTVSIFLFLRGHNAPGGGFIAGLVLAVPLLIQYVIQGTASVESRFGFDYIRCIGMGLLIALLSGSASMLFGVPFLTSGHLDLHLPLIGDVPLASAIGFDIGVYLVVFGGAMLMLSMMGTIKPSRTRTARKGEIDLQRRSARTGEMH
>NZ_CP040438.1|WP_154264654.1|4398570_4398963_+|Na+/H+-antiporter-subunit-C
MELALATAIGVLTAIGIYLLLRARSFDVILGMTFLSYATNLLIFAGGRVVLGKAPVLQEGVDSHLGNYTDPLPQALVLTAIVIAFAMTAVSIVLAMRSRSDNHSDHVDAHEPEDDLQDESVLPRQGEDRA
>NZ_CP040438.1|WP_154264655.1|4398959_4400495_+|monovalent-cation/H+-antiporter-subunit-D
MNHLVILPILIPLLGAALSLFVEHRRYGPRVQRAVAWTALSALALAVGLLFAATATGEINVYLLGDWPSRLGIALVADRLSAWMLLTTLLLAIPCLLHACSGWDRRAPHFHALFQFQLAGLNGAFLTGDIFNLFVFFEVMLIASYGLLLSGGRGLRMRIGLHYVVFNVTASTLFLIALGLLYASLGSLNMAELSQRIAEVPPAQLTLVKATMGLLLLVFCAKAALMPLYLWLPEAYSRAPAAVAALFAIMTKVGLYSVLRIQMLWFGDDAGAMAGYGRDWLLWAGVATLVLGGLGALAATRLRVLISYLVIVSAATLFIAFSIGTPQVLSAGLYYLPHSSFVAAALFLIADLIRRRRGGASDRKEVVAPMPGKETPAVLFLIGAVSVAGLPPLSGFLAKAALLAGMPAQYTAPVWTAVLVSSLLVIMGLTRGGIRLFWRVPPVEADAPKPRKARLRRVELYAACILLAYGIGMTLAAAPLMRYTDATAAQLLHPSEYVQQLRATTPEIRQP
>NZ_CP040438.1|WP_154264656.1|4400491_4400998_+|Na+/H+-antiporter-subunit-E
MTAQRSLFRRVIPSPMLSIMVVAFWLLMSDSFTLGQFLLGLVLGVVVPLFAARLDREFARIGTLRPLPKLLCVTLWDILMSNIRVAVQVLGPEKNIHPGFIWLPLDIANIHGIAALTSMITLTPGTVSAALSDDRKFLLVHVLHLEDPQDLIDTIKRRYEAPLMEIFP
>NZ_CP040438.1|WP_005411334.1|4400994_4401279_+|K+/H+-antiporter-subunit-F
MTGFEVIQTTLVVCMHVVGLAMLLATWRLLRGPTVPDRILALDTLSVTAIAELMLFGMYLNSPIYFEAALIIAMLGFGSTVVLSKFVLRRDIVE
>NZ_CP040438.1|WP_154264657.1|4401275_4401665_+|Na+/H+-antiporter-subunit-G
MITAIQIGLSILLLFGCFFILVGALGLVKLSTFFKRLHAPTKASTLGVGCVLVCSVCYHIFLGQDPQPRELLITVFLFITAPISAHMMAKAALSLLMETRPSLPGNEPAAEEQLPPPEPVREEEATQNR
>NZ_CP040438.1|WP_154264658.1|4402264_4403230_-|sodium:calcium-antiporter
MIAIAIAWFLLGLLLLALGGDSIVKAVSGLAQRFGASPFTAGLLLLGVTTSLPELAVNARALAVGQPELALGNAMGSSIVNLGLTLAVAAMAAPLLLRARLQTVLWWSLLAAGVLLILFGLDGGLARWEGGVLLAGFIVVQVLLLRRGRSESAEVQAAIAESALSRTSLPLNVLRVLIAALALYWGARLVVGAAADFGTALGWTPLLVGLLPVAIGTALPEVATAIAAARRGHGDMVLGHVLGSSVVNLLLVIGAMAVLQPLALPASFVRLELPALLAFALVLYPMLRGDLKISRGEGAILLVAFVGWFVLELLLVGAPAL
>NZ_CP040438.1|WP_154264659.1|4403303_4403960_-|hypothetical-protein
MKHLPLAGLLLLSLTACSAGSDKQGAAGSGSDTPAETASATGPAQSTDPDLAARPANDRREDSPARLDGFGGAKLGAGIAEVRSGFGEPLQGLGTDASGKPLPADDSNDGCYFLRPQNAEDPRLMIEGRKLVRYDVRSAAIIAPGGGKVGMTLGELQVLYPERGDVVPDKYDEKAQHLRVRPAQEGGAVIDFALGADGRVGAWRVGQTPQVDYVEGCG
>NZ_CP040438.1|WP_154264660.1|4404085_4404619_+|hypothetical-protein
MQPRKTDLARTALQAHRAPLDMRQRRLLILCDGQRTIADLTGLLGQDAPAMVIQLVQAGYLSTGTPTPSPAAAAAPVPTPPAAAPAALAAPAVERRRSLVAARIYVLGILEMQRHPQAAALFRDLQQARAEDEVLQRLQSAMQMLPALTSDGYCQRVRQRLLEALPLEHCDAFAEVA

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Crispr_ID: NZ_CP040438_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040438_13

4645702-4645807

Orphan

Consensus_repeat	Method
GTGTGCCAACCAAGGTTGGCACCTAC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP040438_13

>merge|NZ_CP040438|13|4645702-4645807|CRISPRCasFinder
GTGTGCCAACCAAGGTTGGCACCTACCGAGTGAGGAAACATCGTGTCGACCAAGGTCGACATCTACCGGGGGCTGGATAGGTGTGCCAACCAAGCTTGGCACCTAC

>NZ_CP040438|13|13|4645702-4645807|CRISPRCasFinder
GTGTGCCAACCAAGGTTGGCACCTAC	CGAGTGAGGAAACATCGTGTCGACCAAGGTCGACATCTACCGGGGGCTGGATAG
GTGTGCCAACCAAGCTTGGCACCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040438.1\|WP_154265010.1\|4644201_4645620_-\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|234967
NZ_CP040438.1\|WP_006402522.1\|4645921_4646086_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|179075
NZ_CP040438.1\|WP_154264825.1\|4650002_4650338_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154264818.1\|4639882_4640437_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154264824.1\|4649410_4649812_+\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100005
NZ_CP040438.1\|WP_094002267.1\|4633895_4634792_+\|oxygen-dependent-coproporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|235413
NZ_CP040438.1\|WP_154264815.1\|4632224_4633841_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040438.1\|WP_154264822.1\|4647842_4648352_-\|DNA-polymerase-III-subunit-epsilon	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99835
NZ_CP040438.1\|WP_154264819.1\|4640532_4642725_-\|DNA-helicase-II	unknown	unknown	gnl\|CDD\|236976
NZ_CP040438.1\|WP_005411638.1\|4646099_4646336_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NZ_CP040438.1\|WP_154264823.1\|4648407_4649301_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176161
NZ_CP040438.1\|WP_154264828.1\|4652860_4656070_+\|CusA/CzcA-family-heavy-metal-efflux-RND-transporter	unknown	unknown	gnl\|CDD\|129992
NZ_CP040438.1\|WP_154264816.1\|4634875_4635355_-\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NZ_CP040438.1\|WP_154264827.1\|4651644_4652850_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273386
NZ_CP040438.1\|WP_154264821.1\|4646614_4647829_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340817
NZ_CP040438.1\|WP_154264817.1\|4635725_4638500_-\|DNA-polymerase-I	unknown	unknown	gnl\|CDD\|235591
NZ_CP040438.1\|WP_005411629.1\|4639020_4639467_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP040438.1\|WP_154264826.1\|4650394_4651648_+\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NZ_CP040438.1\|WP_154264820.1\|4642734_4644156_-\|SidA/IucD/PvdA-family-monooxygenase	unknown	unknown	gnl\|CDD\|226906
NZ_CP040438.1\|WP_005411628.1\|4638598_4638883_+\|DUF2782-domain-containing-protein	unknown	unknown	gnl\|CDD\|378588

Protein	Function_ID	Function_description	E-value
NZ_CP040438.1\|WP_154265010.1\|4644201_4645620_-\|cardiolipin-synthase	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	3.0823e-140
NZ_CP040438.1\|WP_006402522.1\|4645921_4646086_-\|50S-ribosomal-protein-L33	gnl\|CDD\|179075	PRK00595, rpmG, 50S ribosomal protein L33; Validated.	2.12202e-19
NZ_CP040438.1\|WP_154264821.1\|4646614_4647829_+\|glycosyltransferase	gnl\|CDD\|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	2.98934e-46
NZ_CP040438.1\|WP_154264824.1\|4649410_4649812_+\|RidA-family-protein	gnl\|CDD\|100005	cd02198, YjgH_like, YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	7.20251e-48
NZ_CP040438.1\|WP_094002267.1\|4633895_4634792_+\|oxygen-dependent-coproporphyrinogen-oxidase	gnl\|CDD\|235413	PRK05330, PRK05330, oxygen-dependent coproporphyrinogen oxidase.	0
NZ_CP040438.1\|WP_154264819.1\|4640532_4642725_-\|DNA-helicase-II	gnl\|CDD\|236976	PRK11773, uvrD, DNA-dependent helicase II; Provisional.	0
NZ_CP040438.1\|WP_005411638.1\|4646099_4646336_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	9.01893e-37
NZ_CP040438.1\|WP_154264823.1\|4648407_4649301_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176161	cd08472, PBP2_CrgA_like_3, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 3. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.39632e-95
NZ_CP040438.1\|WP_154264828.1\|4652860_4656070_+\|CusA/CzcA-family-heavy-metal-efflux-RND-transporter	gnl\|CDD\|129992	TIGR00914, Nickel-cobalt-cadmium_resistance_protein_NccA, heavy metal efflux pump, CzcA family. This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds].	0
NZ_CP040438.1\|WP_154264816.1\|4634875_4635355_-\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	1.05995e-37
NZ_CP040438.1\|WP_154264827.1\|4651644_4652850_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273386	TIGR00999, Nickel-cobalt-cadmium_resistance_protein_NccB, Membrane Fusion Protein cluster 2 (function with RND porters). [Transport and binding proteins, Other].	7.44673e-38
NZ_CP040438.1\|WP_154264822.1\|4647842_4648352_-\|DNA-polymerase-III-subunit-epsilon	gnl\|CDD\|99835	cd06131, DNA_pol_III_epsilon_Ecoli_like, DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins. This subfamily is composed of the epsilon subunit of Escherichia coli DNA polymerase III (Pol III) and similar proteins. Pol III is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. It is a holoenzyme complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	2.99315e-92
NZ_CP040438.1\|WP_154264817.1\|4635725_4638500_-\|DNA-polymerase-I	gnl\|CDD\|235591	PRK05755, PRK05755, DNA polymerase I; Provisional.	0
NZ_CP040438.1\|WP_005411629.1\|4639020_4639467_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	5.41846e-31
NZ_CP040438.1\|WP_154264826.1\|4650394_4651648_+\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	4.23414e-27
NZ_CP040438.1\|WP_154264820.1\|4642734_4644156_-\|SidA/IucD/PvdA-family-monooxygenase	gnl\|CDD\|226906	COG4529, COG4529, Uncharacterized protein conserved in bacteria [Function unknown].	2.14892e-84
NZ_CP040438.1\|WP_005411628.1\|4638598_4638883_+\|DUF2782-domain-containing-protein	gnl\|CDD\|378588	pfam11191, DUF2782, Protein of unknown function (DUF2782). This is a bacterial family of proteins whose function is unknown.	9.525e-20

>NZ_CP040438.1|WP_154265010.1|4644201_4645620_-|cardiolipin-synthase
MLFEWLLGSYLLLIDWLIRLVALCWIPTRTTPGAARSWLLLVGFVPLLGLPLYLLFGHPWLSRERIRRQAEASQVIREEQALQHRLRWTPQPDTASAEIVPLVQRQGDFMPVHGNAVDLLTDYDESLHTLIADIDQAEDRVHLLYYLMFDDAVGEAVVEALQRAAARGVQCRVLLDAVGAKRGLRAYRKRLQARDIEVRAMLPGGLRWRRSGRMDLRNHRKIAVIDNEVAYVGSQNLAGPQFVPGHPNRELVARVRGPAVAHLEAVFASDWYMETGQRLDVITDVPECGDDIATQLLPSGPAYPYSNARDAVAALIHLARRRLVMVTPYFVPDEATLSALRIAALSGVQVQLILSASNNQRLTSWAQEAYYDELLRCGVRIALYEPQFLHAKHMSVDEDIAVLGSINMDIRSFALNAEIGLICYDHVLVKQLCGIEDGYLRESRQLDLQQWRSRPTWRRSREGIARLADALM
>NZ_CP040438.1|WP_154264820.1|4642734_4644156_-|SidA/IucD/PvdA-family-monooxygenase
MAYNRHMTDSPRNGELDLAIIGGGAAGVLVAIQVLRQAKAPLALAIFEPASQLAQGIAYATPWPEHLLNVPAAKMSAFADQPGDFLDYLMAANAYPGEAREVLGERYVCRHYFGAYLQQRLQEATAGSPAQLQVIAQPVLGLQPDDHGYQLTLGDGHTLHAAQVVLATGNSMRPLPVAGAEALPADDVIEAWDYDGVRTLAGEQAVAIVGSGLSMADTVLALGAAGHTGPLHVISRHGLLPLPHAHGGLPSFDPAVLLPMNLRQRLRALRGFARQAQADGLPWQGVMDRIRPHGQALWCSLDEADQRRFLRHVVRYWDVHRHRIAEEVDAQLQALTESGQLRIHRSRLQSVGREGDALRLSGRDATGNEQQWTIGGVINATGVETRASALRNPLLQQLQADGLARPGPHGLGLDSTVPGDRLRAVGGQPQARLGVLGSLRIGSLWESLAVPELRQQAQALATQVVAGAATAMP
>NZ_CP040438.1|WP_154264819.1|4640532_4642725_-|DNA-helicase-II
MDVSHLLDGLNPAQREAVSAPPGHHLVLAGAGSGKTRVLTHRIAWLHEVDGVPTHGIFAVTFTNKAAGEMRHRIDAQLPNGSRGMWIGTFHGLANRLLRLHWQDAKLPEGFQVMDSDDQLRLVKRVVQALELDDGKYPAKQIAWWINAQKDEGRRPQHIQPEPHDAWLETMRQAYIEYQARCDRAGLVDFAELLLRAHELLRDNPALLAHYRARFREILVDEFQDTNAIQYAFVRVLAGDSGHVFVVGDDDQAIYGWRGAKVENVQGFLRDFPGAQTIRLEQNYRSTANILGAANAVIAHNPDRIGKQLWTDSGDGEPIDLYAAYNEMDEARYIVERGRQWVRDGGSYTEVAVLYRSNAQSRALEEALLSEQVPYRVYGGMRFFERAEIKDALAYLRLLSNRNDDAAFERAVNTPTRGIGDRTLDEVRREARAQGISLWEATMLVTQGSALAARARNALAGFLVLINELQAQTLHMTLAERVDHVLARSQLREHWSKESRNALDSESRTDNLDELVSVASRFVRRADDIEEVGEDMDELVAFLAYAALEAGEGQAQAGEDGVQLMTLHSAKGLEFPLVFLAGLEEGLFPSARSLEESGRLEEERRLAYVGITRARQKLVLSYAESRRIHGQDNYSLPSRFLREIPRELLHEVRPKVQVSRPASMGASRVMGHASIEAPPIKLGALVTHPKFGEGMVTDYEGNGAHARVQVEFADAGSKWLVMAYANLTVI
>NZ_CP040438.1|WP_154264818.1|4639882_4640437_-|hypothetical-protein
MTEPTLHVTVKLNARLQPEHRHELFEDPLDALLQAAQVGELTGGGTAMSDLGEVEYGDIEVALADAAGVPKLIDLLEQLGAPKGSQLQGAGEADRSFGVTEGLGIYLDGLNLPDDVYEQCDSNHVFEQLSENIDGLGEICSWWQGPTETALYMYGESFEAMRDAIAEFVASYPLCQNARVVQIA
>NZ_CP040438.1|WP_005411629.1|4639020_4639467_-|universal-stress-protein
MYKRILIATDGSELADKGLAKGLELAKDLNAEVDIVTVSEPWAVGMYDAMGWSVGYMNSPEYKADREEGAQKVLQPALAKAAEQGITANPVHVLDRYAADGIIETAGERNSDLIVMTSHGRRGVTRVLLGSQTAEVLARSTLPVLVIR
>NZ_CP040438.1|WP_005411628.1|4638598_4638883_+|DUF2782-domain-containing-protein
MKTLMLASLLLLAGCASMGGAGAPPVDVKGADVSKRTMDNGDVIEEYRVSGQLRMVKVTPSRGAPFYMYDKNGDGRFDNDKDGVSPVYWKLYSW
>NZ_CP040438.1|WP_154264817.1|4635725_4638500_-|DNA-polymerase-I
MSRLVLIDGSSYLYRAFHALPPLSNAQGEPTGALFGVVNMLRSTLKERPAYVAFVVDAPGKTFRDDLYDQYKANRPPMPDELRSQVEPMCRIVEALGISILRIPGVEADDVIGTLALQGLAQDLKVTISTGDKDFAQLVRPGIELVNTMTGSRMDSDAAVMDKFGVRADQIIDLLALMGDTVDNVPGVEKCGPKTAAKWLAEYQHLDGVMAAAPTMKGKIGENLRAALERLPLNRELVTIRTDVELDASPTTLALREQDVPKLTELYARYGFTQALKELGAPLPAPTAASEATPSLRGTAAGFARGSAEAPTAGTLDPALAAPGEYETVLTAEQLQAWVERLQQADLISFDTETDALDAMRARLVGISLAVEPGKAAYIPVGHDYPGAPAQLPMQQVLDALRPALQDPAKKKLGQHGKYDLHVLRRHGVEVQGYHDDTMLESFVLNSTATRHDMDSLALRYLGYNTLKFEDVAGKGAKQIPFSQVGIDEASRYAAEDADITLRLHRALQPQLLAEPALDSVYRDIEMPLVPVLTTIEANGVRIDTDELRRQSQDLSSRMLAAQQKATELAGRSFNLDSPKQLQAVLFDELKLPAVVKTPKGQPSTNEEALEAIADQHELPRVILDYRGLAKLRSTYTDKLPEMVNPDTGRVHTSYHQSGAATGRLSSSDPNLQNIPIRTEDGRRIRRAFIAPDGFRLLAADYSQIELRIMAHLSEDPGLVGAFEKGADVHRATAAEVFGRTLEEVTPNERRAAKAINFGLMYGMSAFGLARNLGIDRGQAQDYVALYFSRYPGVRDFMERMRQQARDQGYVETLFGRRLYLNDIHARNQGLRAGAERAAINAPMQGTAADIIKRAMVDVDQWLRDSGAPARMILQVHDELVFETESSFVEELRLQVVERMSQAAKLRVPLVVDTGIGNNWDEAH
>NZ_CP040438.1|WP_154264816.1|4634875_4635355_-|DUF421-domain-containing-protein
MPDLFALAMPWWEFILRAVVVYVVVLGMVRLGGKRALGQITPFDVLLIVLLGNAVQNALLGTDTSLGGGLLLAATLILLNYGVGWLTTRNRRMERMIEGEPTVIARDGRLLDGVLRRELISPADFDAALRQQGGLRIEDVQVALLETTGHITIIARKHT
>NZ_CP040438.1|WP_094002267.1|4633895_4634792_+|oxygen-dependent-coproporphyrinogen-oxidase
MNEFERVRAYLTDLQDRICAAIEAVDGQARFQEDLWQRAEGGGGRTRVLRDGAVFEQAGIGFSDVAGSRLPPSASANRPELAGASWRATGVSLVFHPLNPYVPTTHANVRFFQAQRDGEVVASWFGGGFDLTPFYPFDEDVQHWHRVARDLCAPFGDERYAAHKRWCDEYFFLRHRNETRGVGGLFFDDLHGDFERDFDYLRAVGDGFLDAYLPIVQQRKDTAYGEREREFQLYRRGRYVEFNLVYDRGTLFGLQSGGRSESILMSLPPRVRWEYGFSPEAGSAEARLADYLVPRDWL
>NZ_CP040438.1|WP_154264815.1|4632224_4633841_+|hypothetical-protein
MHSPAPRRRWLAWALLLAAPTAFAQSPQCGLFKADEGSATLRISSPNRGEQKHFGSAPSPVAFQQIDEKLQLVNLEYGLPSTLQVRDRGRTVEVDGTVYLLQAPAQCAAAATPADGSCLADAAACLDNRREATPTALEAGCREGVPGMCLQLADRWHDEAKPTVEADPALAKAALEAALSGIKLPAACNNGGFEQGTPACAAALEADPAVQEQLVKAAMTAAMTEAMVTMTAPTVPVIIPAERRQQLLRLCREVPHGGFCTRVAELSWDAGDPQQAVQALAAACTPGNDTATCERLPALQAVGASLQPQAATVLPCGNYRSDGGLMDTLDFGDAGLVGVGWGSHLRARVEAGDIRIHHDRGGDFVLRPLPGGQLLGLDTWTRFQVFSPTGEGPARCSAPKQFNVLPLPQDCPLALANEDSAEACCTQGKLQGCNILGNRLALSGNWLQAAEHYTTVCRAGVREGCENLVTAQGNGAELDARATLEQLCKADRSGLHVACDVLGTQNWELITLGGALQKAVDEAAVDDAPAPRNSNRKR
>NZ_CP040438.1|WP_006402522.1|4645921_4646086_-|50S-ribosomal-protein-L33
MAGKRDKVRMISTAGTGHFYTTDKNKKNTPGKMEFSKYDPVVRKHVPYKEGKIK
>NZ_CP040438.1|WP_005411638.1|4646099_4646336_-|50S-ribosomal-protein-L28
MSRVCQVSGKRVQTGNNVSHANNKTRRRFLPNLHERRFWVASENRWVKLRVSAHALRTIDKNGIDSVLAELRARGEKV
>NZ_CP040438.1|WP_154264821.1|4646614_4647829_+|glycosyltransferase
MRLLALTYGTEGDTRPLAMLCHGLIGAGHEVTLLADGGTLGSAQALNVPHASLEGDIHDEVVALVSRGNGVAAASSGLARMALQHVTGWMRQADAAAEGCDAILTGGLAAFVGMSVGERRGLPVIGTGMIPLTPTRAFRSPFLPPGRSPGWLNRASYGLVNGLIWRQFRQPINEARKQLGQSPRRSLWSGLPMLYGISPQLLPPPTDWPADHIVCGQWRFPDAPWTPPADLQAFLDAGPPPVYLGFGSMTGFDRERVLPALLQALAPRRVLLFPGWVGLPAMRLPDSAFVLGPTPHEALFPRCALVIHHGGSGTTHSACRAGIPSLVMPFAADQFFWADRLYRLGVAPAPLSPKRLDAATLAAAITFAEAEATRARAAALGVAMSSEDGVACGVAMIERWLRPM
>NZ_CP040438.1|WP_154264822.1|4647842_4648352_-|DNA-polymerase-III-subunit-epsilon
MSRIVALDTETTGISHRLGHRVIEIGAVELIDGQLTGRQFHTYLQPQRKVDWGAQRVHGISDAMLVGKPLFSSKAAELLEFLRGSEMVAHNATFDVGFLDNELRLAGIPGTLAQHCRITCSLKLARGRWPGQGNKLDDVLQRLRIPGNRGLHGALKDAHLLAQVIPYLR
>NZ_CP040438.1|WP_154264823.1|4648407_4649301_-|LysR-family-transcriptional-regulator
MDRFEAMRAFARVVETGSFTRAAKTLQISRTTVTQLVQQLEAHLRLRLLNRTTRRVSVTADGAAYYPRIARLLAELEEVEGGLGDAATQPRGRLRVDVPGPYARLRLVPALPDFQARYPEIQLDIGVSDREVDVIADNVDCVIRGGTPADPALVARALGALPIGFHASPGYVQRFGLPADPRALEGPDHHMVGFLSPRSGRARVFSAQRGDERVEVQGRHTVGFDDGNAYLAAALAGLGVVALPSYMADPHVARGELLPLLQDWQLPPMPMHVMFPPNRHMSQRLRVFIDWVVEALG
>NZ_CP040438.1|WP_154264824.1|4649410_4649812_+|RidA-family-protein
MSQRDVVFPTGRQALYERNRYSPAIRSNGFLFVSGQVGSREDGSPEPDFETQVRRAFDNLNAVLAASGCSFDAVVDVTVFLVDPGKNFEKAWAIVPEYWGEAPHPTLTGIGVTWLYGFQFEIKVIAKLPADRR
>NZ_CP040438.1|WP_154264825.1|4650002_4650338_+|hypothetical-protein
MRRITRQLRTYLMMLLMAAFVVVPVADALVCAVEPHSSSAHVESLADEEGGDSDSKHTGACTHNHCHHSTLSLPANDFAAFGTPLPARWMNAGDVATYAVAQDELTRPPRA
>NZ_CP040438.1|WP_154264826.1|4650394_4651648_+|TolC-family-protein
MSILTPRSPRAAGLLVAVLLGLAPAMQASAQAAPSYDTLLERLDQLPGTRVGTALAEAADARADQARALPNPSLSYSAENAWGTGSYGGMGKADTVLTLSQPLEVWGQRGARVRAARAEAQAANLRGAQSRSDVASQLAVVYAQAESALRRYSLAEEALALTRDDANAVNAMVKQGREPQLRAVQAQSEVANASAALDEAQAFRDAALARLASAALLDAPVQSIDNSLLDRVPPLPRGATDVALAVRIAEAEADAAGKLVDVERKRALPDLSVTAAQTRFREGGERAYNLGVSLSIPLFDRNRGGIRAANADQRAAEARLDQQRRDSEAARLSAVAGLKAAGSRTRAADESVVAAEEAYRLARVGFDAGRISQLELRSTRSALIAARGTAVDARLSRVGAEIDLARLEGRAPFVEAP
>NZ_CP040438.1|WP_154264827.1|4651644_4652850_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MTLSRTFPLIGGVLLTMLLAGCAGNAQTPANDDPAAAKAGTDDGHGHAADSKEAKAEAAKAPADADEGVVQLTPEQIKASGIEVVAIGRGGGGSTRLSGRVEPTVGARASVASTVTGRVERVLVAPGTAVKQNQALAIVVSGEAAVFRANALAASAEAEAARLAYGRDRALVDQGVVARQEMEASRARSLAAQAQAAAAQAQAAANGSPDSSGRVRITSPVAGIVGNVQVTPGGVVAAGSAVADVTDPSMNELVFTAPPALAAQVTPGMKLEVSVPGGSFTATVTGSAADVRQQGGVAVIRATPVDAALPPAGSPVSAVVVTEGQDGSLSVPADAVQNVDGSSAVFVAVEGGFKAQPVLAGRRAGDRIEILGGLAGNERIVGANAFLLKAELAKGEAEHGH
>NZ_CP040438.1|WP_154264828.1|4652860_4656070_+|CusA/CzcA-family-heavy-metal-efflux-RND-transporter
MFKLIIETAVRHRWLVVFMAALIAAVGLFQLGKLPIDAVPDITNRQVQINTVAPALTPEQIERQVTYPLETALAGIPGLTTTRSLSRNGFSQVTAIFTDATDIYFARQQVAERMREASEDLPDGASPMLSPVTTGLGEVLMWTVDFTAFDPAKLSKPGEAGWQAGEFYRTPEGNLLRTPEERATYLRTVQDWIIAPQMRSSPGLAGVDTVGGYVKEYGVHPDSAKLAAHGLGLADLVTALQRSNVQAGAGFVQRAGEGLVVRADGLALTTDDLAQAPVATRNGVVVRVADVADVDLSRAPRLGAASRNGHEAVLGTALMIAGGNSRTVAQAAAARLEQVNKSLPADIVAAPVLDRSVLVNSTIKTVARNLTEGALLVVVVLFLLLGNLRAATITALVIPLSFLFAVIGMNRFGISGNLMSLGALDFGILVDGAVIVVESTLLMLGQRRAELGRALTAMERLRVAADSAMKMARPAAFGQLIILLVFAPILTLEGVEGKTFHPMAATFMLALVGAFIFSFTFVPAMAALLVREPKVKDGDAHADDGEHETKLIRVLRARIEPAVRKAVGHPRTVLAGAVMMVVVGIGSFSLLGREFMPTLDEGNVAMQALRVPSTSLEQSLAMQLALEKAIAKQPEVETVFSRTGTAEAAIDPMPTNISDSVIVLKPRKDWPDPKLGKDALVARFEKLAGQQLGNSFEFSQPIELRFNELISGVRTDLAVMIFGDDFNQLQKVADQVALKLRAVNGAADVRVEQISGLPTLNVAIDHVAAAQYGLTAADVSDALSTGIGGTAAGKIFEGDRRFNVVVRLDDASRNDPDQLASLPIATPSGLVIPLSSVARITVSEGPNQISRNNGSRRVVVQANVRGRDLGGFVGEAQAAVADVALPPGAYLTWGGQFENLQRAEKRLATVVPVVFLLIGSLLFMALRSGKEAILVFSCVPLALVGGILALLLRGMPFSVSAAVGFIAVSGVATLNGLVLMQAIRERLDAGDLPLQAAINGASSRIRAVLTTALVAIVGFIPMAIASGSGAEVQKPLATVVIGGLITATVLTLLVLPTFAARVAKPRAVG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP040438_4	4.1\|1420910\|19\|NZ_CP040438\|CRISPRCasFinder	1420910-1420928	19	NZ_CP040438.1	1846819-1846837	2	0.895

1. spacer 4.1|1420910|19|NZ_CP040438|CRISPRCasFinder matches to position: 1846819-1846837, mismatch: 2, identity: 0.895

gagcccgggaacaatgagg	CRISPR spacer
gagccggggaacaacgagg	Protospacer
***** ********.****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

652727 : 662359

Enterobacteria_phage(28.57%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_154262223.1\|652727_653783_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	1.7e-80	46.5
WP_154262224.1\|653797_654685_+	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	1.3e-97	60.0
WP_154262226.1\|654681_655239_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	2.1e-45	50.3
WP_154262227.1\|655235_656129_+	dTDP-4-dehydrorhamnose reductase	A0A1D7XFA3	Escherichia_phage	4.1e-27	36.5
WP_049398411.1\|656181_657585_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	3.8e-48	29.1
WP_154262229.1\|657597_658944_-	phosphomannomutase	A0A127AWJ1	Bacillus_phage	1.6e-30	26.8
WP_154264897.1\|659041_662359_-	helicase	Q9YNZ9	Choristoneura_fumiferana_nuclear_polyhedrosis_virus	5.3e-48	30.7

DBSCAN-SWA_2

1821313 : 1832939

Pseudomonas_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_154263137.1\|1821313_1821820_-	DUF1320 domain-containing protein	J9SN75	Pseudomonas_phage	3.9e-27	45.9
WP_154263138.1\|1821819_1822176_-	hypothetical protein	NA	NA	NA	NA
WP_154263140.1\|1822243_1823137_-	hypothetical protein	M4SRT6	Rhodobacter_phage	5.4e-88	55.2
WP_154263141.1\|1823174_1823582_-	hypothetical protein	A0A0M4TU84	Ralstonia_phage	2.0e-18	46.4
WP_154263143.1\|1823614_1824742_-	hypothetical protein	J9SH47	Pseudomonas_phage	6.3e-94	52.8
WP_154263144.1\|1825000_1825552_-	hypothetical protein	M4ST99	Rhodobacter_phage	2.5e-11	30.4
WP_154263146.1\|1825690_1826926_-	hypothetical protein	A0A2H4IYU7	uncultured_Caudovirales_phage	4.3e-51	35.1
WP_154263147.1\|1826882_1828466_-	DUF935 family protein	J9SVY0	Pseudomonas_phage	4.2e-168	58.4
WP_154263148.1\|1828459_1830028_-	hypothetical protein	A0A2H4JF57	uncultured_Caudovirales_phage	5.3e-155	57.9
WP_100552825.1\|1830024_1830603_-	DUF3486 family protein	J9SH37	Pseudomonas_phage	2.2e-26	55.2
WP_049436663.1\|1830608_1830914_-	hypothetical protein	NA	NA	NA	NA
WP_049436662.1\|1830913_1831192_-	hypothetical protein	NA	NA	NA	NA
WP_154263150.1\|1831188_1831404_-	hypothetical protein	NA	NA	NA	NA
WP_154263152.1\|1831565_1831979_-	hypothetical protein	NA	NA	NA	NA
WP_154263153.1\|1832249_1832939_-	transglycosylase SLT domain-containing protein	J9SHG5	Pseudomonas_phage	8.8e-38	47.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP040438

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection