CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP036523	[Clostridium] hiranonis strain DSM 13275 chromosome, complete genome	3 crisprs	cas14i,cas3,c2c10_CAS-V-U3,WYL,DEDDh,csa3,cas14k,cas2,cas1,cas4,cas5,cas7b,cas8b1,cas6	0	5	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP036523_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036523_1

1451724-1452418

Unclear

Consensus_repeat	Method
ATTTACATTCCAATATGGTTCTAATCAAAT	CRISPRCasFinder
ATTTACATTCCAATATGGTTCTAATCAAAT	CRT
ATTTACATTCCAATATGGTTCTAATCAAAT	PILER-CR

10 spacers

c2c10_CAS-V-U3,WYL

The CRISPR arrays of NZ_CP036523_1

>merge|NZ_CP036523|1|1451724-1452418|CRISPRCasFinder,CRT,PILER-CR
ATTTACATTCCAGTATGGTTCTAATCAAATGACTTTCATTATAACTTTATTACAGTTTTCTATAACATTTACATTCCAATATGGTTCTAATCAAATGATATCCATTCTTCTATTTGTATCGAATACAAGATGATTTACATTCCAATATGGTTCTAATCAAATCCTCATATCTTTGTCTATCTTGCTCGATATAATCTCTAATTTACATTCCAATATGGTTCTAATCAAATCATATCATCTTTATTTTTAATTTTGCTAATATCTATATTTACATTCCAATATGGTTCTAATCAAATTCAACCTATGCTGATGATAAGTTCGACGATTATCAAAATTTACATTCCAATATGGTTCTAATCAAATTGGGACCCGAAATAATGCGTGGCTTTACTGTTTTAAATTTACATTCCAATATGGTTCTAATCAAATCAACGTTAAACACTTCTTTGAGTTTTTCAATTACTTATTTACATTCCAATATGGTTCTAATCAAATGACAGAAGAAGAACAAAAAGCTGCAGAACAACAGATGCATTTACATTCCAATATGGTTCTAATCAAATTAAACCAGAAACTGTAACTCTTAAAAATAATATAATATTTACATTCCAATATGGTTCTAATCAAATGCATCAATCTCATTGCATCCTTTTCTATTCCATCATATTTACATTCCAATATGGTTCTAATCAAAT

>NZ_CP036523|1|1|1451724-1452418|CRISPRCasFinder
ATTTACATTCCAGTATGGTTCTAATCAAAT	GACTTTCATTATAACTTTATTACAGTTTTCTATAAC
ATTTACATTCCAATATGGTTCTAATCAAAT	GATATCCATTCTTCTATTTGTATCGAATACAAGATG
ATTTACATTCCAATATGGTTCTAATCAAAT	CCTCATATCTTTGTCTATCTTGCTCGATATAATCTCTA
ATTTACATTCCAATATGGTTCTAATCAAAT	CATATCATCTTTATTTTTAATTTTGCTAATATCTAT
ATTTACATTCCAATATGGTTCTAATCAAAT	TCAACCTATGCTGATGATAAGTTCGACGATTATCAAA
ATTTACATTCCAATATGGTTCTAATCAAAT	TGGGACCCGAAATAATGCGTGGCTTTACTGTTTTAA
ATTTACATTCCAATATGGTTCTAATCAAAT	CAACGTTAAACACTTCTTTGAGTTTTTCAATTACTT
ATTTACATTCCAATATGGTTCTAATCAAAT	GACAGAAGAAGAACAAAAAGCTGCAGAACAACAGATGC
ATTTACATTCCAATATGGTTCTAATCAAAT	TAAACCAGAAACTGTAACTCTTAAAAATAATATAAT
ATTTACATTCCAATATGGTTCTAATCAAAT	GCATCAATCTCATTGCATCCTTTTCTATTCCATCAT
ATTTACATTCCAATATGGTTCTAATCAAAT

>NZ_CP036523|1|1|1451724-1452418|CRT
ATTTACATTCCAGTATGGTTCTAATCAAAT	GACTTTCATTATAACTTTATTACAGTTTTCTATAAC
ATTTACATTCCAATATGGTTCTAATCAAAT	GATATCCATTCTTCTATTTGTATCGAATACAAGATG
ATTTACATTCCAATATGGTTCTAATCAAAT	CCTCATATCTTTGTCTATCTTGCTCGATATAATCTCTA
ATTTACATTCCAATATGGTTCTAATCAAAT	CATATCATCTTTATTTTTAATTTTGCTAATATCTAT
ATTTACATTCCAATATGGTTCTAATCAAAT	TCAACCTATGCTGATGATAAGTTCGACGATTATCAAA
ATTTACATTCCAATATGGTTCTAATCAAAT	TGGGACCCGAAATAATGCGTGGCTTTACTGTTTTAA
ATTTACATTCCAATATGGTTCTAATCAAAT	CAACGTTAAACACTTCTTTGAGTTTTTCAATTACTT
ATTTACATTCCAATATGGTTCTAATCAAAT	GACAGAAGAAGAACAAAAAGCTGCAGAACAACAGATGC
ATTTACATTCCAATATGGTTCTAATCAAAT	TAAACCAGAAACTGTAACTCTTAAAAATAATATAAT
ATTTACATTCCAATATGGTTCTAATCAAAT	GCATCAATCTCATTGCATCCTTTTCTATTCCATCAT
ATTTACATTCCAATATGGTTCTAATCAAAT

>NZ_CP036523|1|1|1451990-1452418|PILER-CR
ATTTACATTCCAATATGGTTCTAATCAAAT	TCAACCTATGCTGATGATAAGTTCGACGATTATCAAA
ATTTACATTCCAATATGGTTCTAATCAAAT	TGGGACCCGAAATAATGCGTGGCTTTACTGTTTTAA
ATTTACATTCCAATATGGTTCTAATCAAAT	CAACGTTAAACACTTCTTTGAGTTTTTCAATTACTT
ATTTACATTCCAATATGGTTCTAATCAAAT	GACAGAAGAAGAACAAAAAGCTGCAGAACAACAGATGC
ATTTACATTCCAATATGGTTCTAATCAAAT	TAAACCAGAAACTGTAACTCTTAAAAATAATATAAT
ATTTACATTCCAATATGGTTCTAATCAAAT	GCATCAATCTCATTGCATCCTTTTCTATTCCATCAT
ATTTACATTCCAATATGGTTCTAATCAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036523.1\|WP_006440230.1\|1456874_1457090_+\|HTH-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP036523.1\|WP_050754658.1\|1457887_1458778_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP036523.1\|WP_006440232.1\|1454353_1455739_-\|PTS-mannitol-transporter-subunit-IICBA	unknown	unknown	gnl\|CDD\|225123
NZ_CP036523.1\|WP_006440227.1\|1458833_1459268_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|236715
NZ_CP036523.1\|WP_050754659.1\|1452777_1453986_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	c2c10_CAS-V-U3	-	gnl\|CDD\|284650
NZ_CP036523.1\|WP_006440241.1\|1440597_1442412_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NZ_CP036523.1\|WP_006440231.1\|1456067_1456838_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379530
NZ_CP036523.1\|WP_006440239.1\|1443577_1443973_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374053
NZ_CP036523.1\|WP_006440240.1\|1442580_1443564_-\|DUF4065-domain-containing-protein	unknown	unknown	gnl\|CDD\|274805
NZ_CP036523.1\|WP_006440237.1\|1444920_1445955_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP036523.1\|WP_006440242.1\|1439917_1440595_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP036523.1\|WP_006440226.1\|1459475_1460273_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP036523.1\|WP_040410444.1\|1462973_1463900_-\|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl\|CDD\|372574
NZ_CP036523.1\|WP_040410446.1\|1449210_1451592_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|376899
NZ_CP036523.1\|WP_006440229.1\|1457507_1457858_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036523.1\|WP_006440238.1\|1444232_1444928_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP036523.1\|WP_006440225.1\|1460431_1462792_-\|ferrous-iron-transport-protein-B	unknown	unknown	gnl\|CDD\|223447
NZ_CP036523.1\|WP_040410552.1\|1438810_1439845_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP036523.1\|WP_006440235.1\|1446791_1449185_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|376899
NZ_CP036523.1\|WP_006440236.1\|1446114_1446780_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222

Protein	Function_ID	Function_description	E-value
NZ_CP036523.1\|WP_006440230.1\|1456874_1457090_+\|HTH-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	5.09022e-15
NZ_CP036523.1\|WP_050754658.1\|1457887_1458778_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.73738e-25
NZ_CP036523.1\|WP_006440232.1\|1454353_1455739_-\|PTS-mannitol-transporter-subunit-IICBA	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NZ_CP036523.1\|WP_006440227.1\|1458833_1459268_-\|N-acetyltransferase	gnl\|CDD\|236715	PRK10562, PRK10562, putative acetyltransferase; Provisional.	1.61569e-45
NZ_CP036523.1\|WP_050754659.1\|1452777_1453986_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|284650	pfam07282, OrfB_Zn_ribbon, Putative transposase DNA-binding domain. This putative domain is found at the C-terminus of a large number of transposase proteins. This domain contains four conserved cysteines suggestive of a zinc binding domain. Given the need for transposases to bind DNA as well as the large number of DNA-binding zinc fingers we hypothesize this domain is DNA-binding.	4.38064e-27
NZ_CP036523.1\|WP_006440241.1\|1440597_1442412_+\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	2.16722e-10
NZ_CP036523.1\|WP_006440231.1\|1456067_1456838_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379530	pfam14268, YoaP, YoaP-like. The YoaP-like domain is found at the C-terminus of the B. subtilis YoaP protein. It is found in bacteria and archaea, and is approximately 40 amino acids in length. The family is found in association with pfam00583. There is a single completely conserved residue A that may be functionally important.	1.32603e-10
NZ_CP036523.1\|WP_006440239.1\|1443577_1443973_-\|hypothetical-protein	gnl\|CDD\|374053	pfam15723, MqsR_toxin, Motility quorum-sensing regulator, toxin of MqsA. MqsR_toxin is a family of bacterial toxins that act as an mRNA interferase. MqsR is the gene most highly upregulated in E. coli persister cells and it plays an essential role in biofilm regulation and cell signalling. It forms part of a bacterial toxin-antitoxin TA system, and as expected for a TA system, the expression of the MqsR toxin leads to growth arrest, while co-expression with its antitoxin, MqsA, rescues the growth arrest phenotype. In addition, MqsR associates with MqsA to form a tight, non-toxic complex and both MqsA alone and the MqsR:MqsA2:MqsR complex bind and regulate the mqsR promoter. The structure of MqsR shows that is is a member of the RelE/YoeB family of bacterial RNases that are structurally and functionally characterized bacterial toxins.y characterized bacterial toxins.	0.00128688
NZ_CP036523.1\|WP_006440240.1\|1442580_1443564_-\|DUF4065-domain-containing-protein	gnl\|CDD\|274805	TIGR03830, transcriptional_regulator_XRE_family, putative zinc finger/helix-turn-helix protein, YgiT family. This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.	1.2498e-20
NZ_CP036523.1\|WP_006440237.1\|1444920_1445955_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.12502e-45
NZ_CP036523.1\|WP_006440242.1\|1439917_1440595_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.09471e-110
NZ_CP036523.1\|WP_006440226.1\|1459475_1460273_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.38587e-78
NZ_CP036523.1\|WP_040410444.1\|1462973_1463900_-\|DUF4097-family-beta-strand-repeat-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	7.25684e-15
NZ_CP036523.1\|WP_040410446.1\|1449210_1451592_+\|FtsX-like-permease-family-protein	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	5.08131e-09
NZ_CP036523.1\|WP_006440238.1\|1444232_1444928_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.25911e-63
NZ_CP036523.1\|WP_006440225.1\|1460431_1462792_-\|ferrous-iron-transport-protein-B	gnl\|CDD\|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	0
NZ_CP036523.1\|WP_040410552.1\|1438810_1439845_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.43309e-41
NZ_CP036523.1\|WP_006440235.1\|1446791_1449185_+\|FtsX-like-permease-family-protein	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	1.11049e-07
NZ_CP036523.1\|WP_006440236.1\|1446114_1446780_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.05334e-106

>NZ_CP036523.1|WP_040410446.1|1449210_1451592_+|FtsX-like-permease-family-protein
MKWPFENDTNNIVKKLAKKNMKSEKRRNIMVIISVVLSTFLVCLSMDLTTSLIKIQRDKAVDTYEACYTNITEQNVTDLKNLPEFARVGEYYIFGEERDSNGYNASYVYCDKDMIYTARNQLNLVSGEIPLKKNEIAVSNGWLSKYNSNKKIGDFIQLNSKNLKGKYKIVGLVDSLDDEKSSTYSFLISKATLKSLNGYNEKGYRAYVHFKNDTHLNKDTMSTQCKEISEKLNLSMPSMNTNYFKFYENRASFSSLFIISILVLAGGYVVIQSIFRISINDKIQNYGQLRTIGTTSKQVRKMVKKEGHWLASIGILLGVLMASITCYIMLPKGFDPLMYAIAAILSIIVCWIMVSISIRKPVKIATKVSPIEAVTFSFNSDNTITSRRKNIKLNPISMGVENFKRDKKRMVSIIASLSFGGILLLIISAVFLTRSPEKFVRQYFPNSDYRVYVDSDISEIELFSSGNPLNDNLKKKILSIDGVTDVIEDREAIFARMTSSKTFSGIAGMCDIITDENFSEIQDYLIEGKMPTDSNSILVAKLISNRFPEIKVGSKVNLILDEKSITVTVSGLYDHLKVTNGHDKLAIDSTQFFTTKSTINKLFPNVDNYNYSWSVVIDPEKEKSVEKTLDNIVAESNNLSLDKFKDRVEYEKMVNEISFGGLQILSWLIFLFGVINLINTTLSNQISRKVENSILRSIGLTEKQLYKMYVTEGLCYLFAATIVTVIVGTPISIVACRKVSTAAFAGRVLPYQFPIFDMGLFVLVLFILEFVLATWSIRKYRQQSLIEQMQSRE
>NZ_CP036523.1|WP_006440235.1|1446791_1449185_+|FtsX-like-permease-family-protein
MKWPFENDTQYSIKKLSYAQLKNNHLKKRLSIFAISLATFLISSVLLLLSGIIVVNQNGGNSITGSYHALIPNITHSQFENLSKDIRVESCGLTSHIESLKFNKDRLNVSFSNKDSLALNGLSISEGKMPTKENEILIEKEFLTSQNINAKIGEQITIPFSDKVTNNKFTITGYLKTSTKGTNRSLYAAMVSEKYFDKLNGWNKLSPAVMLKVNSNNLSSSNDIKNLVLSILKDNNMNQSPSFNEAFIKLSQPSILMILSAIVGLAIIIIASVLVIYCIFYISIINSIKSYGQLRTIGMTSKQIKKLINREGNLLAIIAIPIGLILGVVFSYLLIPKGFKFINLLWISPVVIVLTYITVRISIRKPAKIASTVSPIEASKFESNNQLSYKHNFNKLTPFSLACNQLIRYKKKNLLTLLSISLTGVLLIGFSSILSSIDAREMSLSGFKRGQFVIKINDFELRENPLEKIQVNNPLTEEVYKQLKQISGLKKIEIDKHLPASNNLKSNESDAEIIGFYKEDMPLLEKCNNEKSLPKYYDLSSKDKIVVGRPSDFEEYFGFKAKIGNIVTLKIFDGNTSRNVDFEIAAVLDESKIENNGDKIDMLILPVDSMNRISDANLIYQYVVKVDNNFENLAEKDIEQILLLNPKLGYNSLSSAISQNENFLQSSKLVLISIIILIGCFSIMNLLNTILTGVLVRRKEFALMRSVGMSKSQLFKMVYFETLIVVVSGLVLSVILGGCVGYIVCMILKNSLMSYLNYHFPLMITFIYSLIVIFLSLIISNMSLKHQNELSIIESLR
>NZ_CP036523.1|WP_006440236.1|1446114_1446780_+|ABC-transporter-ATP-binding-protein
MSILQTINLKKYYGTEPNITRAVDDVNFSVEEGEFVAVVGTSGSGKSTLLHMIGGLDKPTSGTVIVRGDDLANKNDEELTIFRRRNIGFVFQNYNLVPILNVYENIVLPVELDGNKVDENFLIEIVGMLGLEDKLKSMPNNLSGGQQQRVAIARALISKPAIILADEPTGNLDSKTSADVLGLLKNSSTKFNQTIVMITHNNDIAQLADRIVRIEDGKIVE
>NZ_CP036523.1|WP_006440237.1|1444920_1445955_+|HAMP-domain-containing-histidine-kinase
MNKFNISDKNLFYFIQFLSIITTLIIGFVGFLISKQSIVMIITFSLVICNIFWMFCLVGILSKKLSIFTSDICDLIDNIVNGKYNPANIKDEDTLFSKINHHLSRLYLIVEQNKNRLDKERNELQSLISDISHQVKTPISNLKMVTETMLTVPISDDDKVEFLNGIQTETDKLDFLINALVKTSRLETGIIHFKKVKNRIYDTIAQAMSGIIYSAEKKNIFVSVECPNDLFLYFDSKWTSEAIFNILDNAVKYTQPGGKISVSVEKHEMYAEIKIADNGKGISESNQATIFKRFYREENVHDQPGVGIGLYLSREIISKQGGYIKVNSKVDKGSIFSIMLPVRQ
>NZ_CP036523.1|WP_006440238.1|1444232_1444928_+|response-regulator-transcription-factor
MRKILIVEDDKFLNKMLTYNLTSDGYDVSSIFNVKSAKDAIEKNEFDLAILDINLPDGNGYDLCDYIKSIHEETLIIFLTANDQESDQIRGYEVGAIDYITKPFVISALQRKIKAMFNILSRNKPKNDIYDDGRLFLDFSEQVASLNGNSINLSPMEYKILNLFCKNKKLVLTRQTLIEKLWDIKGKYIDEHTLTTSISRIRSKIESDGGAPYIKTIYGMGYQWTGGEGNE
>NZ_CP036523.1|WP_006440239.1|1443577_1443973_-|hypothetical-protein
MREYDSVSEILSTIKESVSKGKYFISLNKNRGDNIAFRNKYELSSKDQKQIILNLTEEDYEKSVSNYKEGYENEKLHIFGPILNLKNEEGKSKKVQVYIKFNIIKDNDNLVVVVSFHEARRPMILASCKNK
>NZ_CP036523.1|WP_006440240.1|1442580_1443564_-|DUF4065-domain-containing-protein
MSFSFCEECRKMVEYKIEHKEITEYLKGSCYTYNGEIATCNECGAEVYVPEVLDGNMEKLYSEYRKKNGILNKEEIKLIPEKYKISKKKLSLMLGWGEATFTRYYDGKTPSKRYSKTLEKILKNPNEYLKILEENKEKLKSSEYLKSKEAVMNLIKCENEKKILLFSKYIIKKCGDVTPLSLQKMLYYVQGFYYAFFNSFLFEEDCEAWIHGPVYKDVYDRFKDYRYNQIESEENLDELLFTSLEISILDSVIKNFGCYSGKILEEFTHTEKPWLVARGNIPQNKKSQNIISKESIGEYFISVKNRYSMINPSDIKYYSKEMFNTYN
>NZ_CP036523.1|WP_006440241.1|1440597_1442412_+|FtsX-like-permease-family-protein
MKSYLSLIPISSKIHKRENRLTIMCIICSVFLVTAIFSMAEMGVRMEYENLASTHVDFNIDYLLKNSSTVQSLFSVAIFLFILVSIASILMISSSINSTVVRRIKFFGMMSCIGMSKKQIKTFVRLEALNWCKIGIPIGLVLGILCTWVLCGILKYFVGFEFSTIPMFKISYIGIISGIVLGVVTVLISSNSPAKKASKISPITAVNTNSSNLENKPKSINSRFLKIETALGVNHATSGKKNMWIMSGSFALSIILFLSFSVLIDFVEHIVPQFSNSYNLSISSEDGTNSVDRNLISKLEKINGVQKVFARRSVFDVPTNLGKNLDVNNKSDLISYGNFDLECLEKDDLLEKGSDLSKLFSKGNYVLAISDDKNNVNIGDKILLNGKNFEIAGRLKLNPFSQDGVSDGKITFIASDKVFKNLTGMSDYSLVMIKTSRAFSEKDILSIENILNNRYIFNDMRDQDTSATFFAFKLFIYGFLAVIIVVSVLNIMNSISMSVSARMNQYGSMRAIGVSNKQIVRMISSEAFTYSLCGCFIGCVIGLPISKFIYDFLISSHFAYAKWTLPVTSLVFIFLFVVGASILAVYYPIKRICNTDIRDTINEL
>NZ_CP036523.1|WP_006440242.1|1439917_1440595_+|ABC-transporter-ATP-binding-protein
MDLLEVKSISKTYGAGDTKVEALKDATFSVSKGEFVAIVGESGSGKSTLLNILGGIDTPTSGKVFIDGNDIFNMDNEKLTIFRRRNIGFIFQNFNLIPELTVEQNIIFPILLDYKKTDMDYLEEILSVLNLTERRNHLPSQLSGGQQQRVAIGRALITRPALILADEPTGNLDSKNSSEVITLLKNAAKKYKQTIIMITHSNGIAQAANRIIEVSDGVLTDFGRY
>NZ_CP036523.1|WP_040410552.1|1438810_1439845_+|HAMP-domain-containing-histidine-kinase
MNILSDKDISSLFKKLIFILIVFNVTALFILFSIKSNTYLFIMADYLIMGLLMIYLVYKYFVKQDKIINNASKQIQSYINGNQNARINCNYEGSIYKLFHEINSIVSILNANAKNEEKSKVFLKNTISDISHQLKTPIASLNIYNGIIQGEADGLDTIQEFSNLSEKELDRIENLVQNLLKITKLDAGTLAFEKNPENLSDIMYSIENDFSYRASSEDKSLTFTGDDMEILCDKSWLIEALENIIKNSFDHTKSGNSINVEWRKLPTIIQIVIKDNGSGIHPQDLHHIFKRFYRSRFSKDTQGIGLGLPLAKSIIEEHNGTIEVDSSLGHYTKFTINFSIPTKL
>NZ_CP036523.1|WP_050754659.1|1452777_1453986_-|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MITVRKLKLTIINDDETKRNEQYKFIRDSQYAQYQGLNLAMSVLTNAYLSSNRDIKSDLFKETQKNLKNSSHIFDDITFGKGTDNKSLINQKVKKDFNSAIKNGLARGERNITNYKRTFPLMTRGTALKFSYKDDCSDEIIIKWVNKIVFKVVIGRKDKNYLELMHTLNKVINGEYKVGQSSIYFDKSNKLILNLTLYIPEKKDDDAINGRTLGVDLGIKYPAYVCLNDDTFIRQHIGESLELSKQREQFRNRRKRLQQQLKNVKGGKGREKKLAALDKVAVCERNFVKTYNHTISKRIIDFAKKNKCEFINLEQLTKDGFDNIILSNWSYYELQNMIKYKADREGIKVRYVNPAYTSQKCSKCGYIDKENRPTQEKFKCIKCGFELNADHNAAINISRLEE
>NZ_CP036523.1|WP_006440232.1|1454353_1455739_-|PTS-mannitol-transporter-subunit-IICBA
MKEKIQVMGRFLSGMVMPVIGAFIAWGLITALFIETGWAPNERLAALVSPMSTFLLPLLIAYTGGKMVHGERGGVIGAIATMGVIVGADIPMFMGAMIMGPLSAWIMKKFDQAIEGKVKAGFEMLVNNFSLGILGAILAAVALLGVTPLVEMLNSAMEAGVNFFVQRGLLPLASILIEPAKVLFLNNAINHGIFSPMGIQQVEEVGKSIFFLLEANPGPGLGILLAYCLAGKGSAKSSAPGAVIIEFLGGIHEIYFPYILMNPILIVAAIAGGATGVFVNQMLGSGLTAPASPGSIIAILAMCPKGGYLPVLAGVAAATAVSFAVALPLLKFAGKDADLEESQKKVSDMKSESKGIAVNAEKSEVKSASEVHKIVFACDAGMGSSAMGATVLRKKLKEAGIEDIEVVHAPVSSIPADADMVVTHHELGERAAHSNPNAQLVLIQNFLGAPEYDEVVAQLSK
>NZ_CP036523.1|WP_006440231.1|1456067_1456838_+|GNAT-family-N-acetyltransferase
MDKTFINLTLDNIDSEHICCAISDKKHQIGVSCKKEWLKSQFNSSHVFRKLNERGKVFIEYCDIEDAWVPILGENFVYIHCLWVAGSFKGNGYANELLNYCIEDAKNRGKSGICVLSSKKKKPYLSDKKFFAKYGFKVLDSINNEYELLGLIFDNTDILDKNIPHFSDSAKKMSIDEDILTIYYSHQCPFVVNSIEEVSSYCSENNIDVNIILVDSLEKAKNLPCVFNNWAAFLNGKFESCSLLNKNSLKKLLNSK
>NZ_CP036523.1|WP_006440230.1|1456874_1457090_+|HTH-domain-containing-protein
MSDSRLFKILYYLLKNGTTPVKELAEIFEVSTRTIHRDIDSLGSAGIPICTSRGRHGGVYRISILRAAKSI
>NZ_CP036523.1|WP_006440229.1|1457507_1457858_-|hypothetical-protein
MEIMGFVIWVICGLLFVGIGIYDYMSKKQVGFWANFDVPEVEDVIGFNKAVGRLFITYGVVFILIGIPLIPSIFYKNVLLVFIPIIGTVFETIWLMVYFVMKIEKKYYPKKVYKKR
>NZ_CP036523.1|WP_050754658.1|1457887_1458778_-|alpha/beta-hydrolase
MYFNYRGINIHYECIGEGIPFFMIHGFECDKELMKGCMEPVMEKYDGYKRIYIDLPGMGKSESASWISSSNSILDMLCEFISVIVAGEKFIIAGESYGGYLTRGILSRFTDRVYGMFLICPLILSDYSKMDISRTNLKFMDDNFYEENKDDEDFKEFMKNAVIVNEYTYERYKNEILCGLKIADSKFLNQLSRNYRFPFDVDEKVQNMRFDQPVTILCGRQDNSVGYRDLLKISEDYKRCSISVVDMAGHNLQIERPEVFNLELQDFLKRVEIEIEEQKAKKEGDYSNMKYSKHRR
>NZ_CP036523.1|WP_006440227.1|1458833_1459268_-|N-acetyltransferase
MKIDNIREYKSKDLDNIMEIWVNTNIEAHNFIDENYWRNNFDMVKEMMPSAELYVFDEDGEIKGFVGLMENYIAGIFVKGNNKSKGIGKSLLDFIKEKREELNLSVYEKNTRAIEFYKREGFVVVDKNIEEDNDEVEFLMSWSK
>NZ_CP036523.1|WP_006440226.1|1459475_1460273_-|SDR-family-oxidoreductase
MRLDGKVVLITASTRGIGLACVERFAKEGAKVYMGARNLERAQGVADRLNAEGCKVDIVYNDATEKESYQTMVDEVVAKEGRIDVLVNNFGTSNPKKDLDIKETEYETFIKTVDINLASVFLTSQAVIPHMAKNGGGSIINISSVGGIRPDISQIAYGTSKAAINYLTKIIATHAARDNVRCNAVLPGMTATDAVSDNLSDDFKEFFLKHTPIKRMATPEEIAGTVLYFASDDGAFTTGQVVDVSGGFGMPTPVYGDMIEMKSRR
>NZ_CP036523.1|WP_006440225.1|1460431_1462792_-|ferrous-iron-transport-protein-B
MTLKDLPIGKSAQIVSVGGEGQLRQHFLDMGLIPGVEVSVVKYAPMGDPIELKIHGYELTIRLADAEKIEIIENHHHRAKKDENLEDMKIKKVLNIEKDHPGYGEDGKYHDKKTENPLPDDEVLTFALVGNQNCGKTTLFNQLTGSNQHVGNFPGVTVDRKDGVIRGYSNTLITDLPGIYSMSPYSSEEVVTREFLLNNRPKGIINILDATNIERNLYLTMQLLELDIPMVVALNMMDELKKNDGSVLVSDLEELLGVPVVPISAAKNEGIDELTRHAVHVAKYQEQPLRHDFCTPKGELHRGLHAVMHLIEDHAEEKNIPVRFAATKIVEGDNRILEELELSDTEKRILNDIVKQIEEETGLDASASIAKMRFEFILSVCDATVIKPKESRERVRSKEIDKFLTGKYTGIPIFIGIMGIIFWLTFNVIGSFLQGLLEMGIASLTEVVDQFLTNSNVNDALHSLIIEGIFNGVGGVLSFLPIIVTLFFFLSILEDSGYMARVAFIMDKLLRKLGLSGRSIVPMLIGFGCTVPGVMASRTLPSERDRKVTILLTPFMSCTAKLPIYAFFTAIFFPDNGALVMIGLYVLGMALGILMALLMKKTMFKGEAVPFVMELPNYRLPAAKNIMHLLWDKSKDFLQRAFTVIFLATMVIWFLQNFDYNFNMVADSQQSILAHIAGMMAPIFTPVGFGDWRITTSLISGFLAKESVVSSLTVLFGSTDALLKTLTTAGAGSLLVFCLLYTPCVAAVASIKRELGLKWAIGVVLWQCLLAWLASFATYSILTLII
>NZ_CP036523.1|WP_040410444.1|1462973_1463900_-|DUF4097-family-beta-strand-repeat-protein
MNKKAVAIVCAICIIGAVGYGMRDKFGKDHSDEPSVKKEEKTEDLKEYSDDHIALNDLKEIKADVLDANINIKRSEDNKFYMSYNFEGENGKDPLVYKTEGDNGDKLVIKDKRRDDPNKEGDFEKKDTKTEKTDKDKKDNADTNKEESKDKKEVKNNITIYVPEGAELKKTKVDLLSGKISVEDLHSKELKIKLSSGDVDLNRCLIKDSGVEVSDGNITATESKFEGKTVLESSTGDLSAKFMKEDLDHMNINADTTAGVVKQNLGGSTSEDEYSSNSSYVWKAKDPKHSLEMYTVDGDISLDLVNKN

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Crispr_ID: NZ_CP036523_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036523_2

2369007-2369212

Orphan

Consensus_repeat	Method
CANCCACATTCTTCTCCATG	CRT

4 spacers

csa3

The CRISPR arrays of NZ_CP036523_2

>merge|NZ_CP036523|2|2369007-2369212|CRT
CATCCACATTCTTCTCCATGATCGTGGTGATGGTGTTCTCCACAGCCACATTCTTCTCCATGATCGTGGTCATGTTCGTGATGGTGGTGTTCTTCGCAGCCACATTCTTCTCCATGGTCGTGATTGTGATGATGTTCTCCACAGCCACATTCTTCTCCGTGGTCGTGATCGTGATGATGTTCTCCACATCCACAACTTTCACCATG

>NZ_CP036523|2|2|2369007-2369212|CRT
CATCCACATTCTTCTCCATG	ATCGTGGTGATGGTGTTCTCCA
CAGCCACATTCTTCTCCATG	ATCGTGGTCATGTTCGTGATGGTGGTGTTCTTCG
CAGCCACATTCTTCTCCATG	GTCGTGATTGTGATGATGTTCTCCA
CAGCCACATTCTTCTCCGTG	GTCGTGATCGTGATGATGTTCTCCA
CATCCACAACTTTCACCATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036523.1\|WP_006441112.1\|2364465_2364933_+\|DUF1097-domain-containing-protein	unknown	unknown	gnl\|CDD\|368942
NZ_CP036523.1\|WP_006441111.1\|2365146_2366541_-\|sodium:alanine-symporter-family-protein	unknown	unknown	gnl\|CDD\|224040
NZ_CP036523.1\|WP_006441108.1\|2370527_2371268_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP036523.1\|WP_040410731.1\|2376033_2376777_+\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|319796
NZ_CP036523.1\|WP_040410736.1\|2377373_2377796_-\|'four-disulfide-core'-protein	unknown	unknown	gnl\|CDD\|372602
NZ_CP036523.1\|WP_006441109.1\|2369958_2370330_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NZ_CP036523.1\|WP_006441113.1\|2363724_2364375_+\|hemolysin-III-family-protein	unknown	unknown	gnl\|CDD\|273425
NZ_CP036523.1\|WP_050754681.1\|2355702_2356065_-\|energy-coupling-factor-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|179494
NZ_CP036523.1\|WP_006440553.1\|2351664_2353932_-\|DUF3553-domain-containing-protein	unknown	unknown	gnl\|CDD\|273429
NZ_CP036523.1\|WP_118549247.1\|2356027_2356684_-\|energy-coupling-factor-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|181384
NZ_CP036523.1\|WP_006440552.1\|2354071_2354887_-\|energy-coupling-factor-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224047
NZ_CP036523.1\|WP_006441107.1\|2371283_2371949_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP036523.1\|WP_006441101.1\|2376827_2377337_-\|DUF2232-domain-containing-protein	unknown	unknown	unknown
NZ_CP036523.1\|WP_006441106.1\|2371963_2372770_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270427
NZ_CP036523.1\|WP_006440551.1\|2354919_2355600_-\|cobalt-ECF-transporter-T-component-CbiQ	unknown	unknown	gnl\|CDD\|185382
NZ_CP036523.1\|WP_006441114.1\|2362470_2363430_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270271
NZ_CP036523.1\|WP_006441105.1\|2372795_2373464_-\|DUF169-domain-containing-protein	unknown	unknown	gnl\|CDD\|376845
NZ_CP036523.1\|WP_006441103.1\|2374807_2375905_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036523.1\|WP_006440554.1\|2350316_2351609_-\|M18-family-aminopeptidase	unknown	unknown	gnl\|CDD\|235073
NZ_CP036523.1\|WP_006441104.1\|2373456_2374293_-\|DUF169-domain-containing-protein	unknown	unknown	gnl\|CDD\|376845

Protein	Function_ID	Function_description	E-value
NZ_CP036523.1\|WP_006441112.1\|2364465_2364933_+\|DUF1097-domain-containing-protein	gnl\|CDD\|368942	pfam06496, DUF1097, Protein of unknown function (DUF1097). This family consists of several bacterial putative membrane proteins.	1.5454e-13
NZ_CP036523.1\|WP_006441111.1\|2365146_2366541_-\|sodium:alanine-symporter-family-protein	gnl\|CDD\|224040	COG1115, AlsT, Na+/alanine symporter [Amino acid transport and metabolism].	8.48712e-170
NZ_CP036523.1\|WP_006441108.1\|2370527_2371268_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	3.28837e-136
NZ_CP036523.1\|WP_040410731.1\|2376033_2376777_+\|HAD-IB-family-hydrolase	gnl\|CDD\|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	8.53773e-46
NZ_CP036523.1\|WP_006441109.1\|2369958_2370330_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	6.07572e-23
NZ_CP036523.1\|WP_006441113.1\|2363724_2364375_+\|hemolysin-III-family-protein	gnl\|CDD\|273425	TIGR01065, Hypothetical_UPF0073_protein_yqfA., channel protein, hemolysin III family. This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.	9.8114e-56
NZ_CP036523.1\|WP_050754681.1\|2355702_2356065_-\|energy-coupling-factor-ABC-transporter-substrate-binding-protein	gnl\|CDD\|179494	PRK02898, PRK02898, energy-coupling factor ABC transporter substrate-binding protein.	3.27602e-44
NZ_CP036523.1\|WP_006440553.1\|2351664_2353932_-\|DUF3553-domain-containing-protein	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP036523.1\|WP_118549247.1\|2356027_2356684_-\|energy-coupling-factor-ABC-transporter-permease	gnl\|CDD\|181384	PRK08319, PRK08319, energy-coupling factor ABC transporter permease.	1.73645e-120
NZ_CP036523.1\|WP_006440552.1\|2354071_2354887_-\|energy-coupling-factor-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224047	COG1122, CbiO, ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism].	1.39421e-96
NZ_CP036523.1\|WP_006441107.1\|2371283_2371949_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	8.30704e-64
NZ_CP036523.1\|WP_040410736.1\|2377373_2377796_-\|'four-disulfide-core'-protein	gnl\|CDD\|372602	pfam13432, TPR_16, Tetratricopeptide repeat. This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.	0.000319333
NZ_CP036523.1\|WP_006441106.1\|2371963_2372770_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270427	cd13709, PBP2_YxeM, Substrate binding domain of an ABC transporter YxeMNO; the type 2 periplasmic binding protein fold. This group contains cystine-binding domain (YxeM) of a periplasmic receptor-dependent ATP-binding cassette transporter and its closely related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.59253e-53
NZ_CP036523.1\|WP_006440551.1\|2354919_2355600_-\|cobalt-ECF-transporter-T-component-CbiQ	gnl\|CDD\|185382	PRK15485, PRK15485, energy-coupling factor ABC transporter transmembrane protein.	7.56859e-64
NZ_CP036523.1\|WP_006441114.1\|2362470_2363430_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270271	cd13553, PBP2_NrtA_CpmA_like, Substrate binding domain of ABC-type nitrate/bicarbonate transporters, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes nitrate (NrtA) and bicarbonate (CmpA) receptors. These domains are found in eubacterial perisplamic-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. These binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.79304e-39
NZ_CP036523.1\|WP_006441105.1\|2372795_2373464_-\|DUF169-domain-containing-protein	gnl\|CDD\|376845	pfam02596, DUF169, Uncharacterized ArCR, COG2043.	1.37696e-50
NZ_CP036523.1\|WP_006440554.1\|2350316_2351609_-\|M18-family-aminopeptidase	gnl\|CDD\|235073	PRK02813, PRK02813, putative aminopeptidase 2; Provisional.	0
NZ_CP036523.1\|WP_006441104.1\|2373456_2374293_-\|DUF169-domain-containing-protein	gnl\|CDD\|376845	pfam02596, DUF169, Uncharacterized ArCR, COG2043.	1.40365e-35

>NZ_CP036523.1|WP_006441111.1|2365146_2366541_-|sodium:alanine-symporter-family-protein
MELFLDNLLEVVVAVNGFLWNFLLLFILCGVGIYYTFKLKFIQVRKFGEGFRLVFGNLKLNGEKKEHGEMTPFQSLATAIAAQVGTGNLTGAATALLSGGPGAIFWMWLSAFFGMATIYSEATLAQKYKTVVDGEVTGGPVYYIRAAFTGKFGKILAATFSVLIILALGFMGNMVQSNSIGAAFSEVFASRNINIPPITVGLLIAVVAGFVFIGGTQRLASVVEKIVPIMAFVYIIGSLALIGMNISEVPEAFKMIIVGAFNPKAVLGGAVGISIKEAIRYGVARGLFSNEAGMGSTPHAHARAAAKNPHEQGLTAMVSVFIDTFIILNLTAFSILTSGVLDSGKEGIALTQTAFVNTFGSGGDIFIAVCLLFFAFSTILGWHFFGRINVKYLFGQKAVKIYSLIVILFIIVGSTLKVELVWQLADCFNGLMVIPNAIALFALSGVVMGIYKKYVNGDSNKDEK
>NZ_CP036523.1|WP_006441112.1|2364465_2364933_+|DUF1097-domain-containing-protein
MSKKLSNNTLSAFATALLCTIWMVIANATGLLGWAGFAGCTAYFAGPKKGVSALPLTFACVGSGVAYALISVHLGSQIDFAQIGLVFTFVTTFLMCAGGKIGIISFVPGAFMGSFSTFAAGGDFMIIPSIAAGIILGLCCDTLGKKLCAIFGSEE
>NZ_CP036523.1|WP_006441113.1|2363724_2364375_+|hemolysin-III-family-protein
MSFNYVREPGNGFTHLFGAILSFIGLLALVIKTSIVMPTPLAIASVIIFGISMILLYTASTVYHLVISSDKVIAWLRKIDHSMIFVLIAGSYAPFCMISLKGNGGYALFAIVSIAAIAGVCFKLIWFKCPRWISTIIYIAMGWVSVALIVPLYHALSFSGLMLLVGGGLFYTIGAVIYATKPKLLEFKHFGFHEIFHIFIILGSLCHFLCVFFYVL
>NZ_CP036523.1|WP_006441114.1|2362470_2363430_-|ABC-transporter-substrate-binding-protein
MNKKLLSVILSSAIVAGALVGCSGKSVSSDSKKMTVGALESVNIIQPFFYDEFSDESENLEVNTFEGYDEMKDTVISGKLDIAATNWISAIKAAEKGEDIKVIAGMSNGGSALVVKKDSGIENIEDLKGKTIGYFPESIEYVKLANELKEKGIDIKKDVKFKEMDLESMTKELSGGNIDAFCGEEPYVSIALEDGFGKVIDYKSDEIVPLNTAIIATEENIKDNPEKMRELMDKHVKSTNHLMMSKEDRINKVAEFGIDKKYLEKSIDNIELSTDISPEMIEEVKKLAEKMKEIGMIDNIPNIENMFDLSMLENSMMKR
>NZ_CP036523.1|WP_118549247.1|2356027_2356684_-|energy-coupling-factor-ABC-transporter-permease
MHIMEGFLPKQWSLIWTIVFIPFFIVGIRSINKIVKEEPKKKVLLALCGAFVFVLSALKIPSVNGSCSHPTGVGLSAILFGPGVTVVLGTIVLLFQAILLAHGGLTTLGANAFSMAIVGPIVSYLIFKGMEKVCKNRKVNVFLAAALGDLATYTVTSFQLAFAFPAATGGVMASAIKFLGIFFVTQVPIAIAEGILTVIVYNLIVENVEGVDFNVKNN
>NZ_CP036523.1|WP_050754681.1|2355702_2356065_-|energy-coupling-factor-ABC-transporter-substrate-binding-protein
MWKELILMSKTTKTNILLIILAIALIVLPLVVNPGAEYGGADGHAEEAITEINPEYEPWFASFYEPPSGEIESLLFSTQAAFGAGIIGYILGNLKGKKSGREEMRKELEAKTSEKSDDKE
>NZ_CP036523.1|WP_006440551.1|2354919_2355600_-|cobalt-ECF-transporter-T-component-CbiQ
MLIIDKYAYTNSLSEKNPYIKTIFSILFLIISLIIENPVYQIAIIATMSIIILSTSKMGISEYLKLLSIPLIFMIMSILAIIISISTEKTDMLTYFTIGSTYIGISKFGLSSALKILARSISCLTCVYFLMLTTPFNQLIQVFKKLHIPDNVIEIAMLIYRFIFIFLEEVHEIYKSQEMKMGYMGMKNSYNSLGLLVNMLYKRMMKRYEDMSIALDMKLFDGKFHI
>NZ_CP036523.1|WP_006440552.1|2354071_2354887_-|energy-coupling-factor-ABC-transporter-ATP-binding-protein
MYKIENLSFKYEKNKNALKNINMDFSKGDIIGVIGENGCGKSTLFMNMTGILKPESGEILYNGEKIKYGKKDLYSLRKRVGMVFQDPEKQIFYSKVYDDIAFTMRNIGIDEEEIKIRIEKALEAVNGSEFIDKPVQFLSYGQKKRVAIASVIAMQNETVLLDEPTSGLDPRSTDAVVEIIKNMKKNGTKVVISSHDMDLIYEICDYVYVMNKGEIIKEGNSDDVFMDEKMIKNAGLKTPWIIKIYNELKNNEANDKEIKLDTIKIKFAQYK
>NZ_CP036523.1|WP_006440553.1|2351664_2353932_-|DUF3553-domain-containing-protein
MNLDTLNPSQRRAVERTEGPVLILAGAGSGKTRVLTTRIAHLIDKGVQPANILAITFTNKAANEMRERVEETVESDTKDMWISTFHSCCVRILRKDINKIGYNRSFVIYDAADQVTLIKDCLKELNISDKAFEPKTVISYISGAKDKLKSPKQYKDDCAGDPRMSKIADIYSLYQDRLKRNSALDFDDLIIKTVELFKKNPEVLDYYRSRFRYIMVDEYQDTSMAQYEFIKQLAMGHKNICVVGDDDQSIYGWRGADIRNILEFEKDYDDVFVVKLEQNYRSTQVILDAANHVISNNIERKRKKLWSEKTEGEKIKIELAENELEEGRFIAETIIDKVQGEGRKYSDCAVLYRANAQARPIEDALNRAGVPYNIYGGTKFYERKEIKDLIAYLRIIANPQDDISLKRIINVPRRGIGLRTIEKIEDRASLKQESMYSVLLDIDSNSEISTKAKKQINGFVDLVGTLRAIKEVYPVSKLIEKVLDSTGYIYELEEEMKKNQNSMNGKYEEAQDRIDNLNEFISIALEFENSDDENLEDKSLETFLTSVALTSEATEDEEPNRVSLMTMHTSKGLEFPVVFITGMEEGLFPISRAIKSMKDSDIEEERRLCYVGITRAREELYLTMTEKRTLYGKTNHAIQSRFIEELPDECIEKLYMGKRELTYTKSSYNILDKYTKKYMNSMNREEVAKKMNATNKNENTMAEPEDIKLGSKVYHPKFGVGTVVAMAGSDVTIAFENQGIKKINKEYTTLDLVKE
>NZ_CP036523.1|WP_006440554.1|2350316_2351609_-|M18-family-aminopeptidase
MKKFAENMLDFIYESPTQFNAVEVSAETLEKNGFEKLNPKENWKLEVGKKYYTTKNSSALVAFKINSDEIEKEGFRIIGSHTDSPGFRIKPNAEMESCGAYLKLNTEGYGGMILSTWLDRPLAMAGRVFLRGENPFKPVEKIVNINKPVCIIPNLAIHMNRSINDGYKYNKQTDMLPLVGLINEQLEKDNYMVKLLASELEVEVEEIIDFDIFLYEYEKGCFTGANGEFISTGRLDNLSMYYSSVEALLDSDSKSGISIAVGFDNEEVGSSTKQGADSNMLLNILERICISLGKDRQQFFEAIENSFIISSDLAHAVHPNVNGMADPTNRPVMGKGPVIKVHAGQAYTSDGYSISVYKEICRACGVEYQEFVNKSDQRGGSTIGPISSTHIDIPSVDIGAPILSMHSIRELGCSEDFYNTYKTFVKFYEI
>NZ_CP036523.1|WP_006441109.1|2369958_2370330_-|helix-turn-helix-transcriptional-regulator
MKNKEIDCCTEKKIHEEVVDKTKKEMPDEEVLADLSDLFRVFGDTTRVKIIFALFSNEMCVCDIAELLGMTQSAISHQLRVLKNARLVKFRKEGKTVFYSLDDEHISEILKCGLEHVNETYKR
>NZ_CP036523.1|WP_006441108.1|2370527_2371268_-|amino-acid-ABC-transporter-ATP-binding-protein
MLKLKNIKKQFGDLTVLDGIDLELKKGEVAAIIGPSGTGKSTLLRCINLLETPTKGTIEIDGFSVDSKNLSPKDCIELRKKTAMVFQNYSLFKNKTVLENIMMPMTLVQKKDKKVAEEEAMALLKKVGLADKRDYYPSRLSGGQQQRIGIARALAVHPEIILFDEPTSSLDPELVNEVLELIRELSNEHECTMLIVTHEMRFALEIANKIIFMEKGKVVEEGSPNELLYNSTNERTRSYFKQFIDN
>NZ_CP036523.1|WP_006441107.1|2371283_2371949_-|amino-acid-ABC-transporter-permease
MRFNFEFFFSCFPALIAKIPFTLYLGVISFIASMALAIVLLIMRNSKISIFKGFATLFISFFRSTPYITQLFIFYYGLPQLIPSLVNLSAEVSFVISVALNSSAFIVEILRGGLLAVDKGQREAALSIGLNKFQVMTQVVIPQAFVSILPSLGNTFVGAVKNTAIAFTIGVVEILSESKILAARGFNYMEAYIAAGIVYWILILAIDLVQNRLEKRVCKFL
>NZ_CP036523.1|WP_006441106.1|2371963_2372770_-|transporter-substrate-binding-domain-containing-protein
MKFGKKLLSCILVGAVVMGSLVGCGNKEASGGDEKAPIKVATAPIFPPCSYKDDEGNLAGFEHDVFEEIGKRCGRKIEWIEGDSQDALFGAVDSGKADTIAFQISITDERKETYDFSEVYGYNKIFFAVRDDFDYKDLDDLQGKKANVPPVHSFYPTLEKYNESLPEDKKIIIIPSDSGSMYEALEQGRYDACPITEAAFKEAMSKKPYKVKIAGEPIVLEENAYPFSKDADPELVKDVNDAIKSMLEDGTMKKLSEQHYKIDVTAKN
>NZ_CP036523.1|WP_006441105.1|2372795_2373464_-|DUF169-domain-containing-protein
MNKETILKVQDCLGLERQIVGVRFLVYEKDFENSPAEEFNGKIRLCGFISKAGKGRKFKVTKENFGCSGGPTQTGMSVVSEGFKSGQVHKYSGLYSDLAIARNISDSLMRIPQKIYGLEIMPLSEMDDADVVVVIGFAESIMKLVQGYTYSYGVPQNYISVGNAAACSDMVSKPFMKNDINLSFMCCGARTSTLSDHGELGMGIPMNKFYGIADGVLAIYSK
>NZ_CP036523.1|WP_006441104.1|2373456_2374293_-|DUF169-domain-containing-protein
MDNLQITRVSKALGLENKILGLRFLVLEKEYNDSLAEEHEGLSLCSLVKLACRGKSVKCNASTIGCDDAAYAMGLKEVPEYVYSGRKEYEDRKYLSKSIAFQVQNEKKYIPQKIYGAIISPLEEIENPDLVIVIATAKDMMRLTQGYSRYYGVNKNLLSIGVQGICSELVSKPFMNNDLNVSLLSNCCRKLTDFSAGCMGASFPIHLVENIFRGILETVNLTENNIPKKKILERLDSPDELGFEIVMNYDYAIQASKYEEYCEECIKACSNDKEGSNE
>NZ_CP036523.1|WP_006441103.1|2374807_2375905_-|hypothetical-protein
MELKFNFAKITQSRLMGSMGMIIDSTDENGDDIKQYFLLDSEGLGLCDYVKLINPSEKKAYMEEERLMGGLGSDRIEISEEEAKFLIQHFGSRNIRYGKELAGEVEDYIDIINDFKSDLNIYDLYPKICKEVKEEIEFVNYMVMRLVAWDREALTYYSESEEIGSMHITNINGALLKTDVTSRGNGKYVVETIYEDNDGYYFCKVALSIEKNEKGFKLNSMVVSESEPMYDFEVFDEISKEEFVDIYTVEDGEEFVEKFYEDNPFVLRSDMDEDAVFFTRFNFNNDHVKRMSYVINNDIKAIYYYLDGMFFVGTYSERDRDYINGLLKVNYKGLEYQDSMFFEQNALYDFVESGNDDFYDFLDEE
>NZ_CP036523.1|WP_040410731.1|2376033_2376777_+|HAD-IB-family-hydrolase
MKKRAAFFDIDGTLYRDSLMVEHFKKLIKYEIIDEKTWIDHARGTFLNWDKRQGNYDDYLLEVCNLYVDSLTGVDWRSIDFAADQVIKTKADRVYKYTRSQIERHLKNGDIVIFISGSPDFLVKKMAEKYNVTDYLGSKYIMEDGKFSGKLVPMWDSESKNKAINELIEKYDIDLDESFAYGDTNGDINMLRKVGHPVAINPTNELLSKLREDPVLKKKADIIVERKDILYKLKPDVQVLSYDDLSD
>NZ_CP036523.1|WP_006441101.1|2376827_2377337_-|DUF2232-domain-containing-protein
MENVSKKMAFGGILLALEAIFFMLINFVPMNTIFFMVLASFISSIIIIEFGEKTGTIFTFASILLSFMIIGNKVQWFIYAISFALYGLVKSLIERGRSMGTEYCIKLVFANIVFAIMYFVLKSFLTEVQYMFVLFIGLNATFLIYDLFYSQFIRMYENKLRKNISKYLD
>NZ_CP036523.1|WP_040410736.1|2377373_2377796_-|'four-disulfide-core'-protein
MNRNVYIEARNLIANRRFADAYRMLKEVVSSDRNAEWFFLTGTAAMKMGRYEEGEDYIKRARFMEPENKEYDEAYNQFSSYRNNYDDRARYYNESRRYDSSGCCPCCCCCCGDDCTDTCCQLWCLDSCCECMGGDFISCC

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Crispr_ID: NZ_CP036523_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036523_3

2495708-2497784

TypeI-B

Consensus_repeat	Method
ATTTAAATACATCAAATGTTATTAATAAGC	CRISPRCasFinder
ATTTAAATACATCAAATGTTATTAATAAGC	CRT
ATTTAAATACATCAAATGTTATTAATAAGC	PILER-CR

31 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

The CRISPR arrays of NZ_CP036523_3

>merge|NZ_CP036523|3|2495708-2497784|CRISPRCasFinder,CRT,PILER-CR
CATTAAATACATCAAATGTTATTAATACGCTCTTTTAGCTAATTCACATAACAAGCAGGCAGTTATATTTAAATACATCAAATATTATTAATACGCACAAAGTTAATGTATCAATTTATGCAAAACCTGAATTATTTAAATACATCAAATGTTATTAATAAGCAGGTATAGCTAGAAGGGAAAGCTTCCTATCTGTATCATTTAAATACATCAAATGTTATTAATAAGCAGTAACTATAATAATGGCAGTGGTTGGAGTATTTACATTTAAATACATCAAATGTTATTAATAAGCATGTTTCTGGATTAAGTGATGCACCTGTATGGACTGAATTTAAATACATCAAATGTTATTAATAAGCTCGTTCATTTTGAATGTTTTCTTTATAGCAACATAAATTTAAATACATCAAATGTTATTAATAAGCACAGGACAAATTAGTAGAAGCAGGATTAAGTCTGAAATTTAAATACATCAAATGTTATTAATAAGCATTGAATGATTATAATATTGAAATAAATTCTTTAAAATTTAAATACATCAAATGTTATTAATAAGCCAAAGCTAACTTTTAGCACTGTAACTCCTTTTTCTAATTTAAATACATCAAATGTTATTAATAAGCTACTTCTTCTAGCAATATCATCATCTGGAAAATTTTTATTTAAATACATCAAATGTTATTAATAAGCGAGCTTTTAATGCTTCTATTTCTTGATTTATTTTCATTTAAATACATCAAATGTTATTAATAAGCATTTATAAATCATTCTTTCATGATCTGTATAAAGCATTTAAATACATCAAATGTTATTAATAAGCATGGACCTTTGCTAGAGTTAGGATGTCCTCCACACGATTTAAATACATCAAATGTTATTAATAAGCTTCTCTAGTCCACTTTCTTATACCTAGTACTATTGCATTTAAATACATCAAATGTTATTAATAAGCGTATAGTTATTATAATATTTCTACTAATTTCATTTATTTAAATACATCAAATGTTATTAATAAGCCTATATGTTTATGTTTATAACTATATCCTGATGGAGAATTTAAATACATCAAATGTTATTAATAAGCCCTTCTATTCCAGCTTTTCGGTTAGAAGGTGTGTGATTTAAATACATCAAATGTTATTAATAAGCTGTGCAGTTTTAGTCAAATAACCACTACTAAAGCTTATTTAAATACATCAAATGTTATTAATAAGCTTAGAAATAGAAAATGCAGAAATGAAGCCAAAAGCGAATTTAAATACATCAAATGTTATTAATAAGCATAGCTCTAAACTCCCTAGCATCAGTGTTCTTAAGATTTAAATACATCAAATGTTATTAATAAGCAGTTGTAATCTTTGGAAATAGCAATACCGCAGTAGAATTTAAATACATCAAATGTTATTAATAAGCATAGAAATCAAAAGCGTTCATATCACGATAAGATCCAATTTAAATACATCAAATGTTATTAATAAGCAAGATTGGAGGTGGAATGAATGGCGAATGGTAGAACATTTAAATACATCAAATGTTATTAATAAGCCTGTGATATTCTATACAGATTTATCCCAACATCTATATTTAAATACATCAAATGTTATTAATAAGCTCCAGAACAGGCTAAGTATATTTTCGGTGATTCTTAATTTAAATACATCAAATGTTATTAATAAGCTTCGCAGCCCATTTTTGTGACTTCATAACATTTATTATTTAAATACATCAAATGTTATTAATAAGCGCGTTCAGAGATGATGCCAGAAGTAAAAGAATTCTAATTTAAATACATCAAATGTTATTAATAAGCCCTCTTTAACATCTGTTATATTCATAAATTTACTTAAATTTAAATACATCAAATGTTATTAATAAGCTATAAGATGCCCAATCTTCAATAGTTAATTTATATCATTTAAATACATCAAATGTTATTAATAAGCCTGCTTTGTTTATCGACGTCTGCAGCTGCTCCACCATTTAAATACATCAAATGTTATTAATAAGCCATCTAACTCGGCATTAACGGAATCTAAATTACCAAATTTAAATACATCAAATGTTATTAATAAGC

>NZ_CP036523|3|2|2495708-2497784|CRISPRCasFinder
CATTAAATACATCAAATGTTATTAATACGC	TCTTTTAGCTAATTCACATAACAAGCAGGCAGTTAT
ATTTAAATACATCAAATATTATTAATACGC	ACAAAGTTAATGTATCAATTTATGCAAAACCTGAATT
ATTTAAATACATCAAATGTTATTAATAAGC	AGGTATAGCTAGAAGGGAAAGCTTCCTATCTGTATC
ATTTAAATACATCAAATGTTATTAATAAGC	AGTAACTATAATAATGGCAGTGGTTGGAGTATTTAC
ATTTAAATACATCAAATGTTATTAATAAGC	ATGTTTCTGGATTAAGTGATGCACCTGTATGGACTGA
ATTTAAATACATCAAATGTTATTAATAAGC	TCGTTCATTTTGAATGTTTTCTTTATAGCAACATAA
ATTTAAATACATCAAATGTTATTAATAAGC	ACAGGACAAATTAGTAGAAGCAGGATTAAGTCTGAA
ATTTAAATACATCAAATGTTATTAATAAGC	ATTGAATGATTATAATATTGAAATAAATTCTTTAAA
ATTTAAATACATCAAATGTTATTAATAAGC	CAAAGCTAACTTTTAGCACTGTAACTCCTTTTTCTA
ATTTAAATACATCAAATGTTATTAATAAGC	TACTTCTTCTAGCAATATCATCATCTGGAAAATTTTT
ATTTAAATACATCAAATGTTATTAATAAGC	GAGCTTTTAATGCTTCTATTTCTTGATTTATTTTC
ATTTAAATACATCAAATGTTATTAATAAGC	ATTTATAAATCATTCTTTCATGATCTGTATAAAGC
ATTTAAATACATCAAATGTTATTAATAAGC	ATGGACCTTTGCTAGAGTTAGGATGTCCTCCACACG
ATTTAAATACATCAAATGTTATTAATAAGC	TTCTCTAGTCCACTTTCTTATACCTAGTACTATTGC
ATTTAAATACATCAAATGTTATTAATAAGC	GTATAGTTATTATAATATTTCTACTAATTTCATTT
ATTTAAATACATCAAATGTTATTAATAAGC	CTATATGTTTATGTTTATAACTATATCCTGATGGAGA
ATTTAAATACATCAAATGTTATTAATAAGC	CCTTCTATTCCAGCTTTTCGGTTAGAAGGTGTGTG
ATTTAAATACATCAAATGTTATTAATAAGC	TGTGCAGTTTTAGTCAAATAACCACTACTAAAGCTT
ATTTAAATACATCAAATGTTATTAATAAGC	TTAGAAATAGAAAATGCAGAAATGAAGCCAAAAGCGA
ATTTAAATACATCAAATGTTATTAATAAGC	ATAGCTCTAAACTCCCTAGCATCAGTGTTCTTAAG
ATTTAAATACATCAAATGTTATTAATAAGC	AGTTGTAATCTTTGGAAATAGCAATACCGCAGTAGA
ATTTAAATACATCAAATGTTATTAATAAGC	ATAGAAATCAAAAGCGTTCATATCACGATAAGATCCA
ATTTAAATACATCAAATGTTATTAATAAGC	AAGATTGGAGGTGGAATGAATGGCGAATGGTAGAAC
ATTTAAATACATCAAATGTTATTAATAAGC	CTGTGATATTCTATACAGATTTATCCCAACATCTAT
ATTTAAATACATCAAATGTTATTAATAAGC	TCCAGAACAGGCTAAGTATATTTTCGGTGATTCTTA
ATTTAAATACATCAAATGTTATTAATAAGC	TTCGCAGCCCATTTTTGTGACTTCATAACATTTATT
ATTTAAATACATCAAATGTTATTAATAAGC	GCGTTCAGAGATGATGCCAGAAGTAAAAGAATTCTA
ATTTAAATACATCAAATGTTATTAATAAGC	CCTCTTTAACATCTGTTATATTCATAAATTTACTTAA
ATTTAAATACATCAAATGTTATTAATAAGC	TATAAGATGCCCAATCTTCAATAGTTAATTTATATC
ATTTAAATACATCAAATGTTATTAATAAGC	CTGCTTTGTTTATCGACGTCTGCAGCTGCTCCACC
ATTTAAATACATCAAATGTTATTAATAAGC	CATCTAACTCGGCATTAACGGAATCTAAATTACCAA
ATTTAAATACATCAAATGTTATTAATAAGC

>NZ_CP036523|3|3|2495708-2497784|CRT
CATTAAATACATCAAATGTTATTAATACGC	TCTTTTAGCTAATTCACATAACAAGCAGGCAGTTAT
ATTTAAATACATCAAATATTATTAATACGC	ACAAAGTTAATGTATCAATTTATGCAAAACCTGAATT
ATTTAAATACATCAAATGTTATTAATAAGC	AGGTATAGCTAGAAGGGAAAGCTTCCTATCTGTATC
ATTTAAATACATCAAATGTTATTAATAAGC	AGTAACTATAATAATGGCAGTGGTTGGAGTATTTAC
ATTTAAATACATCAAATGTTATTAATAAGC	ATGTTTCTGGATTAAGTGATGCACCTGTATGGACTGA
ATTTAAATACATCAAATGTTATTAATAAGC	TCGTTCATTTTGAATGTTTTCTTTATAGCAACATAA
ATTTAAATACATCAAATGTTATTAATAAGC	ACAGGACAAATTAGTAGAAGCAGGATTAAGTCTGAA
ATTTAAATACATCAAATGTTATTAATAAGC	ATTGAATGATTATAATATTGAAATAAATTCTTTAAA
ATTTAAATACATCAAATGTTATTAATAAGC	CAAAGCTAACTTTTAGCACTGTAACTCCTTTTTCTA
ATTTAAATACATCAAATGTTATTAATAAGC	TACTTCTTCTAGCAATATCATCATCTGGAAAATTTTT
ATTTAAATACATCAAATGTTATTAATAAGC	GAGCTTTTAATGCTTCTATTTCTTGATTTATTTTC
ATTTAAATACATCAAATGTTATTAATAAGC	ATTTATAAATCATTCTTTCATGATCTGTATAAAGC
ATTTAAATACATCAAATGTTATTAATAAGC	ATGGACCTTTGCTAGAGTTAGGATGTCCTCCACACG
ATTTAAATACATCAAATGTTATTAATAAGC	TTCTCTAGTCCACTTTCTTATACCTAGTACTATTGC
ATTTAAATACATCAAATGTTATTAATAAGC	GTATAGTTATTATAATATTTCTACTAATTTCATTT
ATTTAAATACATCAAATGTTATTAATAAGC	CTATATGTTTATGTTTATAACTATATCCTGATGGAGA
ATTTAAATACATCAAATGTTATTAATAAGC	CCTTCTATTCCAGCTTTTCGGTTAGAAGGTGTGTG
ATTTAAATACATCAAATGTTATTAATAAGC	TGTGCAGTTTTAGTCAAATAACCACTACTAAAGCTT
ATTTAAATACATCAAATGTTATTAATAAGC	TTAGAAATAGAAAATGCAGAAATGAAGCCAAAAGCGA
ATTTAAATACATCAAATGTTATTAATAAGC	ATAGCTCTAAACTCCCTAGCATCAGTGTTCTTAAG
ATTTAAATACATCAAATGTTATTAATAAGC	AGTTGTAATCTTTGGAAATAGCAATACCGCAGTAGA
ATTTAAATACATCAAATGTTATTAATAAGC	ATAGAAATCAAAAGCGTTCATATCACGATAAGATCCA
ATTTAAATACATCAAATGTTATTAATAAGC	AAGATTGGAGGTGGAATGAATGGCGAATGGTAGAAC
ATTTAAATACATCAAATGTTATTAATAAGC	CTGTGATATTCTATACAGATTTATCCCAACATCTAT
ATTTAAATACATCAAATGTTATTAATAAGC	TCCAGAACAGGCTAAGTATATTTTCGGTGATTCTTA
ATTTAAATACATCAAATGTTATTAATAAGC	TTCGCAGCCCATTTTTGTGACTTCATAACATTTATT
ATTTAAATACATCAAATGTTATTAATAAGC	GCGTTCAGAGATGATGCCAGAAGTAAAAGAATTCTA
ATTTAAATACATCAAATGTTATTAATAAGC	CCTCTTTAACATCTGTTATATTCATAAATTTACTTAA
ATTTAAATACATCAAATGTTATTAATAAGC	TATAAGATGCCCAATCTTCAATAGTTAATTTATATC
ATTTAAATACATCAAATGTTATTAATAAGC	CTGCTTTGTTTATCGACGTCTGCAGCTGCTCCACC
ATTTAAATACATCAAATGTTATTAATAAGC	CATCTAACTCGGCATTAACGGAATCTAAATTACCAA
ATTTAAATACATCAAATGTTATTAATAAGC

>NZ_CP036523|3|2|2495774-2497784|PILER-CR
ATTTAAATACATCAAATATTATTAATACGC	ACAAAGTTAATGTATCAATTTATGCAAAACCTGAATTATT
TAAATACATCAAATGTTATTAATAAGCAGG	TATAGCTAGAAGGGAAAGCTTCCTATCTGTATCATT
TAAATACATCAAATGTTATTAATAAGCAGT	AACTATAATAATGGCAGTGGTTGGAGTATTTACATT
TAAATACATCAAATGTTATTAATAAGCATG	TTTCTGGATTAAGTGATGCACCTGTATGGACTGAATT
TAAATACATCAAATGTTATTAATAAGCTCG	TTCATTTTGAATGTTTTCTTTATAGCAACATAAATT
TAAATACATCAAATGTTATTAATAAGCACA	GGACAAATTAGTAGAAGCAGGATTAAGTCTGAAATT
TAAATACATCAAATGTTATTAATAAGCATT	GAATGATTATAATATTGAAATAAATTCTTTAAAATT
TAAATACATCAAATGTTATTAATAAGCCAA	AGCTAACTTTTAGCACTGTAACTCCTTTTTCTAATT
TAAATACATCAAATGTTATTAATAAGCTAC	TTCTTCTAGCAATATCATCATCTGGAAAATTTTTATT
TAAATACATCAAATGTTATTAATAAGCGAG	CTTTTAATGCTTCTATTTCTTGATTTATTTTCATT
TAAATACATCAAATGTTATTAATAAGCATT	TATAAATCATTCTTTCATGATCTGTATAAAGCATT
TAAATACATCAAATGTTATTAATAAGCATG	GACCTTTGCTAGAGTTAGGATGTCCTCCACACGATT
TAAATACATCAAATGTTATTAATAAGCTTC	TCTAGTCCACTTTCTTATACCTAGTACTATTGCATT
TAAATACATCAAATGTTATTAATAAGCGTA	TAGTTATTATAATATTTCTACTAATTTCATTTATT
TAAATACATCAAATGTTATTAATAAGCCTA	TATGTTTATGTTTATAACTATATCCTGATGGAGAATT
TAAATACATCAAATGTTATTAATAAGCCCT	TCTATTCCAGCTTTTCGGTTAGAAGGTGTGTGATT
TAAATACATCAAATGTTATTAATAAGCTGT	GCAGTTTTAGTCAAATAACCACTACTAAAGCTTATT
TAAATACATCAAATGTTATTAATAAGCTTA	GAAATAGAAAATGCAGAAATGAAGCCAAAAGCGAATT
TAAATACATCAAATGTTATTAATAAGCATA	GCTCTAAACTCCCTAGCATCAGTGTTCTTAAGATT
TAAATACATCAAATGTTATTAATAAGCAGT	TGTAATCTTTGGAAATAGCAATACCGCAGTAGAATT
TAAATACATCAAATGTTATTAATAAGCATA	GAAATCAAAAGCGTTCATATCACGATAAGATCCAATT
TAAATACATCAAATGTTATTAATAAGCAAG	ATTGGAGGTGGAATGAATGGCGAATGGTAGAACATT
TAAATACATCAAATGTTATTAATAAGCCTG	TGATATTCTATACAGATTTATCCCAACATCTATATT
TAAATACATCAAATGTTATTAATAAGCTCC	AGAACAGGCTAAGTATATTTTCGGTGATTCTTAATT
TAAATACATCAAATGTTATTAATAAGCTTC	GCAGCCCATTTTTGTGACTTCATAACATTTATTATT
TAAATACATCAAATGTTATTAATAAGCGCG	TTCAGAGATGATGCCAGAAGTAAAAGAATTCTAATT
TAAATACATCAAATGTTATTAATAAGCCCT	CTTTAACATCTGTTATATTCATAAATTTACTTAAATT
TAAATACATCAAATGTTATTAATAAGCTAT	AAGATGCCCAATCTTCAATAGTTAATTTATATCATT
TAAATACATCAAATGTTATTAATAAGCCTG	CTTTGTTTATCGACGTCTGCAGCTGCTCCACCATT
TAAATACATCAAATGTTATTAATAAGCCAT	CTAACTCGGCATTAACGGAATCTAAATTACCAAATT
TAAATACATCAAATGTTATTAATAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036523.1\|WP_006441125.1\|2499738_2502324_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|350688
NZ_CP036523.1\|WP_006441119.1\|2508419_2509325_-\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|224868
NZ_CP036523.1\|WP_006441120.1\|2507152_2508340_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NZ_CP036523.1\|WP_006441139.1\|2479659_2480364_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|273761
NZ_CP036523.1\|WP_006441132.1\|2491377_2491929_-\|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein	unknown	unknown	gnl\|CDD\|379137
NZ_CP036523.1\|WP_006441123.1\|2503129_2504092_-\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP036523.1\|WP_006441130.1\|2494783_2495614_-\|formate/nitrite-transporter-family-protein	unknown	unknown	gnl\|CDD\|376497
NZ_CP036523.1\|WP_006441131.1\|2491971_2494338_-\|anaerobic-ribonucleoside-triphosphate-reductase	unknown	unknown	gnl\|CDD\|235937
NZ_CP036523.1\|WP_006441136.1\|2482147_2483020_-\|stage-0-sporulation-family-protein	unknown	unknown	gnl\|CDD\|224688
NZ_CP036523.1\|WP_040410738.1\|2504107_2505907_-\|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	unknown
NZ_CP036523.1\|WP_006441127.1\|2498205_2499204_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP036523.1\|WP_170239666.1\|2505939_2506617_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CP036523.1\|WP_006441124.1\|2502376_2503126_-\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_CP036523.1\|WP_040410751.1\|2484673_2486161_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|224893
NZ_CP036523.1\|WP_040410740.1\|2483973_2484648_-\|deoxynucleoside-kinase	unknown	unknown	gnl\|CDD\|223203
NZ_CP036523.1\|WP_006441138.1\|2480397_2481231_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|381175
NZ_CP036523.1\|WP_006441137.1\|2481287_2482043_-\|tRNA1(Val)-(adenine(37)-N6)-methyltransferase	unknown	unknown	gnl\|CDD\|226608
NZ_CP036523.1\|WP_040410741.1\|2483016_2483952_-\|DNA-polymerase-III-subunit-delta'	unknown	unknown	gnl\|CDD\|273213
NZ_CP036523.1\|WP_006441126.1\|2499216_2499705_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP036523.1\|WP_006441128.1\|2497921_2498203_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856

Protein	Function_ID	Function_description	E-value
NZ_CP036523.1\|WP_006441125.1\|2499738_2502324_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	8.10342e-31
NZ_CP036523.1\|WP_006441119.1\|2508419_2509325_-\|nucleoside-hydrolase	gnl\|CDD\|224868	COG1957, URH1, Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism].	2.07157e-30
NZ_CP036523.1\|WP_006441120.1\|2507152_2508340_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	2.11299e-177
NZ_CP036523.1\|WP_006441139.1\|2479659_2480364_-\|HD-domain-containing-protein	gnl\|CDD\|273761	TIGR01693, UTase_glnD, [Protein-PII] uridylyltransferase. This model describes GlnD, the uridylyltransferase/uridylyl-removing enzyme for the nitrogen regulatory protein PII. Not all homologs of PII share the property of uridylyltransferase modification on the characteristic Tyr residue (see Prosite pattern PS00496 and document PDOC00439), but the modification site is preserved in the PII homolog of all species with a member of this family. [Central intermediary metabolism, Nitrogen metabolism, Regulatory functions, Protein interactions].	2.9676e-08
NZ_CP036523.1\|WP_006441132.1\|2491377_2491929_-\|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein	gnl\|CDD\|379137	pfam13353, Fer4_12, 4Fe-4S single cluster domain. This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	1.89234e-52
NZ_CP036523.1\|WP_006441123.1\|2503129_2504092_-\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	3.49226e-39
NZ_CP036523.1\|WP_006441130.1\|2494783_2495614_-\|formate/nitrite-transporter-family-protein	gnl\|CDD\|376497	pfam01226, Form_Nir_trans, Formate/nitrite transporter.	1.23083e-80
NZ_CP036523.1\|WP_006441131.1\|2491971_2494338_-\|anaerobic-ribonucleoside-triphosphate-reductase	gnl\|CDD\|235937	PRK07111, PRK07111, anaerobic ribonucleoside triphosphate reductase; Provisional.	0
NZ_CP036523.1\|WP_006441136.1\|2482147_2483020_-\|stage-0-sporulation-family-protein	gnl\|CDD\|224688	COG1774, COG1774, Uncharacterized homolog of PSP1 [Function unknown].	7.42771e-98
NZ_CP036523.1\|WP_006441127.1\|2498205_2499204_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.42565e-150
NZ_CP036523.1\|WP_170239666.1\|2505939_2506617_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	4.94385e-14
NZ_CP036523.1\|WP_006441124.1\|2502376_2503126_-\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	3.55249e-47
NZ_CP036523.1\|WP_040410751.1\|2484673_2486161_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|224893	COG1982, LdcC, Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism].	6.63133e-109
NZ_CP036523.1\|WP_040410740.1\|2483973_2484648_-\|deoxynucleoside-kinase	gnl\|CDD\|223203	COG0125, Tmk, Thymidylate kinase [Nucleotide transport and metabolism].	4.01755e-30
NZ_CP036523.1\|WP_006441138.1\|2480397_2481231_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|381175	cd11648, RsmI, Ribosomal RNA small subunit methyltransferase I (RsmI), also known as rRNA (cytidine-2'-O-)-methyltransferase. RsmI is an S-AdoMet (S-adenosyl-L-methionine or SAM)-dependent methyltransferase responsible for the 2'-O-methylation of cytidine 1402 (C1402) at the P site of bacterial 16S rRNA. Another S-AdoMet-dependent methyltransferase, RsmH (not included in this family), is responsible for N4-methylation at C1402. These methylation reactions may occur at a late step during 30S assembly in the cell. The dimethyl modification is believed to be conserved in bacteria, may play a role in fine-tuning the shape and functions of the P-site to increase the translation fidelity, and has been shown for Staphylococcus aureus, to contribute to virulence in host animals by conferring resistance to oxidative stress.	5.03829e-126
NZ_CP036523.1\|WP_006441137.1\|2481287_2482043_-\|tRNA1(Val)-(adenine(37)-N6)-methyltransferase	gnl\|CDD\|226608	COG4123, COG4123, Predicted O-methyltransferase [General function prediction only].	2.39499e-91
NZ_CP036523.1\|WP_040410741.1\|2483016_2483952_-\|DNA-polymerase-III-subunit-delta'	gnl\|CDD\|273213	TIGR00678, DNA_polymerase_III_subunit_delta', DNA polymerase III, delta' subunit. This model describes the N-terminal half of the delta' subunit of DNA polymerase III. Delta' is homologous to the gamma and tau subunits, which form an outgroup for phylogenetic comparison. The gamma/tau branch of the tree is much more tighly conserved than the delta' branch, and some members of that branch score more highly against this model than some proteins classisified as delta'. The noise cutoff is set to detect weakly scoring delta' subunits rather than to exclude gamma/tau subunits. At position 126-127 of the seed alignment, this family lacks the HM motif of gamma/tau; at 132 it has a near-invariant A vs. an invariant F in gamma/tau. [DNA metabolism, DNA replication, recombination, and repair].	4.28444e-50
NZ_CP036523.1\|WP_006441126.1\|2499216_2499705_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.67098e-53
NZ_CP036523.1\|WP_006441128.1\|2497921_2498203_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.05064e-22

>NZ_CP036523.1|WP_006441130.1|2494783_2495614_-|formate/nitrite-transporter-family-protein
MGFQTITEVIEQNIQNGIKKTNLTTKKLILLGIAAGFFIGIGAEASSLAMHGISNVGLARTVAGAVFPIGLMLIVLLGGELFTGNCLISMAVYDKKAKLKGMIRNLTIVYISNFIGAALMAWMINNCGQLNFSDGGAGAFTIKVALGKVGIDPIQAIVSGILCNVLVCLAIFMAATAKDVAGKCIAIFFPIFVFVISGFEHCVANMYYIPAGIFAAHNPLYAAKATELYGITAEQLSGLNFGTMFSNLVPVTIGNIIGGMVFVGLLYWYLYRKKEV
>NZ_CP036523.1|WP_006441131.1|2491971_2494338_-|anaerobic-ribonucleoside-triphosphate-reductase
MIEFIKKRDGRTIPFNENKITRAIFLAASDVAKKEGKAPDFKMAEDLTQEVIALLERRFGEEVPSVEDVQDAVVKVLIETGHAKTSEEYILYRAERTRVRNSKTRLMKAIEKITFSDAGDADIKRENANIDGNTAMGTMLQYGSAVSKEFCKTNVLKPEHAMAHDSGDIHIHDMDFLNMGTLTCCQIDVEKLFEGGFSTGHGFLREPNDIMSYGALAAIAIQSNQNDQHGGQSIPFFDYGLAEGVHKTFRKLYISNLTKGLVLLDELDDEATNESVKEIVYNVEKETNVKASLDINKSEEFTTRVIEKLAAKFSITVVEAEKIEKFAYREAYKETDRKTYQSMEAFIHNLNTMHSRAGAQVPFSSINFGTDTSSEGRMVSKNLLLSQEKGLGNGETPIFPILIFKVKEGVNLNPGDPNYDLFKLSCRVSAKRLFPNFSFLDAPFNAKYYVPGNPETEATYMGCRTRVIGNVCGPETVSGRGNLSFTTINLPRLGIIHGCVDGSNPDIDGFFKDLDEKIDLVIDQLLERMEIQGKKKMKNFPFLMGQGVWMGSDELGPEDELEDVIKQGTLTVGFIGLAECLIALIGKHHGESEDAQKLGLAIVSHMKDRMDEATEKYGLNFSLIGTPAEGLSGRFTEIDKKKYGEIKGVTDKEYYTNSFHVPVYYNISAYEKINIEAPYHEYTNGGHITYVELDGDPTNNLDAFESVVRAMKDAGIGYGSINHPVDRDPVCGYSGIINGDICPACGRNEKDSDIKFERIRRITGYLVGTVDRFNNAKRAEVRDRVKHM
>NZ_CP036523.1|WP_006441132.1|2491377_2491929_-|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein
MDIRIASDVTFDSIVDGPGLRAVVWTQGCKHNCIGCHNPQTHSTMGGKVVDTSEIIDKIKSKKLQSGVTLSGGEPFLQPEAVGEIASAVKEMGMNVWSFTGFTFEQLIDKKNKNYFSNIRLLNNIDVLVDGKFEFDKKDISLKFRGSSNQRIIDVKKSLKLGRVVIREKYTENYIDNFLPMAK
>NZ_CP036523.1|WP_040410751.1|2484673_2486161_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MNKNNDELFINNGLKKILDEKIVSFHMPGHKCGKIYDRLKYTEMLEGLYKTDTTEIPGTDNLHSPEDIIKESILKAEKVFESGKTYYLINGSTCGIEAAIMATCNPGEKLILSRDSHQSAVNACILGDIVPIYVKSEIDKYTNIQRGNSFEDVKKAIDENEDTKVLFLTYPTYYGITFELEKIISYAHDKEMVVVIDEAHGAHLGLSEKLPKTALECGADIVIQSTHKTLPAFTQSSMMHISKEALKSGRVDTDRIEKMLKMTETSSPSYILMQSLEIAVDIYEKYGKELMEELINNINEFKIKIEEINEYTNKTKIKNVDFFKIHNEKDLTKIFISSLEVGLTGYEFEEILRKEHNIQVELSNYSGALMIATIGNEKEDFEKLENALIEIYIKSLEEGRKKIEPVDYPYELIPQMALTPREAFYSRKKKNVKIEESIGKICGENIVPYPPGVCMIAAGEIIPQEIMDYLKYCKKEGMEITGVKDSRFEYIQIID
>NZ_CP036523.1|WP_040410740.1|2483973_2484648_-|deoxynucleoside-kinase
MNGKLIIIESGSDASGKATQSEELLKKLTADGYNVRKVEYPNYKSESSTLVKMYLRGDFGKHADDVDAYIASTFFTADRYASFKTEWEEFYRSGGIVIADRYTTSNMVHQASKMEIEERDKYLDWLEDYEYNLFKIPRPDEVIFLNVPVDYSIKLMENRKNKFTGEEEKDIHESDKNYLRKTYNNSLYIADKYNWKRVECVENEQLRTIEDISNEIYEIVKNIL
>NZ_CP036523.1|WP_040410741.1|2483016_2483952_-|DNA-polymerase-III-subunit-delta'
MYFDQIKGQDFAKRYISNAMNKNMLNNAYIFEGIKGIGKKTFAREFAKILIGVSPENSPDFNVIAKEEGSHRIKIEKIRKMKEDVYEKPISDYKIYVIENAELMSEEAQNAILKTIEEPPGYAIFILIAENKEALLNTIKSRCDIVKFVPLSNDIVKNHLIENLGLDEEYAKMCANFSKGSITRAIELANDEEFKEMREFIQNCISIISEKKKLEIERLADGVEKYEKQIMNFLDIMVNYFRDIIMFKEGINLLTNTDRITFIENMSDKINGSQIAKIIDIIEDTKKKLKGFCSFKMSMQVMFLNIYEVIK
>NZ_CP036523.1|WP_006441136.1|2482147_2483020_-|stage-0-sporulation-family-protein
MIKIVGVRFKKAGKIYYFDPAGLDIEVNQDVIVETARGLEFGHVVVGGKEISEEELVSPLKPIIRIATEEDKKVYNENKEKAKETFVLCQEKIKEHGLTMCLIDCEYTFDRNKLIFYFTAEGRIDFRELVKDLASIFKTRIELRQIGVRDEAKSIGGLGPCGRKLCCSAWLGDFQPVSIKMAKDQSLSLNPTKISGICGRLFCCLKYEHDVYAEALEKLPVVGALVQTSEGKGKVIEVNPLLEQVRVEFQDKTIRVYLKDDVQILKEPRRERNGEYIDAETMKELKRLED
>NZ_CP036523.1|WP_006441137.1|2481287_2482043_-|tRNA1(Val)-(adenine(37)-N6)-methyltransferase
MNVEIKEQERVDDLQLKGLKIIQNTDGFCFGTDAVLLANFARVKNGARVADLGTGTGIIPLIIYGKNNVEKIYGVEIQEEVFEMASRTVKMNEIEDKIEIVNADLKEIKEVLPQNTFDVVTSNPPYMHSEGVKNPNDKKMISRHEVKCNLDDVIKAASILLKERGKFFMIHRPTRLIDIVTIGRKYRLEPKIMRFIHPRADKAPNLLLVEFTKGGKPDLKIMDPLYVYDNEGNYTQEILDIYSEDYKTPSR
>NZ_CP036523.1|WP_006441138.1|2480397_2481231_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MAGKLYICPTPIGNLEDITYRTLRILNEVDLIAAEDTRHSLQLLNHFDISKPLTSYHEHNKDSKGGYLITKLLEGENIALISDAGMPGISDPGQDIISEAIENNIEIEVLPGATAFVTALVGAGMDTHKFVFEGFLDRDKKLRRKRLEEIKNEKRTIIFYESPHRLKETLKDMLKYLGNRKIAVNRELTKKYQEIIREDIETVIEIFNNREVKGEFVLIVEGFSGEVEEIGKYDDLNEREYVIQLMEEGINKKDAIKIVCKDRKLKKDIVYKQVLDL
>NZ_CP036523.1|WP_006441139.1|2479659_2480364_-|HD-domain-containing-protein
MEKIRRKFLEALKAQNTSEIIEQMDKDGELEKIFPHIIEMKKIGKCRYHVVDSFTHSMNALKELEKVINERFFPNHLVEFVRDDIETQVDDEFKKVELLKLATFLHDMGKPKSMTIGEDGNAHFKGHEKLGADMLHDVIADFGISEEAENIVHKYIEYHMMLLEFYKNDNMGKKVLYKAFRKVGADIAGIMIIGYSDVVCTRRLIYENENYGVLRTYIDYALTSYYYRFDEESE
>NZ_CP036523.1|WP_006441128.1|2497921_2498203_-|CRISPR-associated-endonuclease-Cas2
MKNKNYNYAFLFYDVGEKRVRKVFKICKKYLVHYQNSVFRGDITPSKIISLKSELKKVVNEDDFICIIKMMNDSCFEEDVIGEKRYKDDELIL
>NZ_CP036523.1|WP_006441127.1|2498205_2499204_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MGSTKYITSMGELTRKDNSICFRKNSKNVYIPIENTKEIYILNEVSINTKLLDYLSRNNIIVHFFNYYEGYSGTFYPKEKYRSGKLLLKQVEKFNSSRIEVAKAIVLGIGENISELLQHYYKHGKKEVKEVIDWIKKELPGKVSEAATVPEVMAYEGELWYRFYASFKYFVNEEFIMNKRVKRPPDNPMNAMISFGNSLLYSKVISVIYQTHLDQRISFLHEPSEGRFSLSLDLSEVFKPIIVFKTIFNLVNNKRIKVEKHFEKSVNYCVLNEEGREIFIKEFESRMEAVFKHDRLKRKISYKTAIKLDCYKLIKYILEDKEFVPFSAKEGV
>NZ_CP036523.1|WP_006441126.1|2499216_2499705_-|CRISPR-associated-protein-Cas4
MINGTLINYYFHCKRQCYLHGNKINLEDNSEEVKIGRAIHEEKLDSGNVELAIDNIKIDKITRDYLVEVKKSDADLEAAKWQTLYYLKVLKEKGIVKKGKIEFCEKNKSDKKTMIVELNEENERELDEYILKIEKLLEGDEVPKVEKKPKCKKCAYYYYCYI
>NZ_CP036523.1|WP_006441125.1|2499738_2502324_-|CRISPR-associated-helicase/endonuclease-Cas3
MDIYAHRKGNKEKELLSEHQDLCLDYFKRIDKEKGILDKVEKCVLKYLERNLTKDEMQIFKDAFVDAIWHHDEGKRNPVFQREKMKNNNIMKEKELDKISEDIGEGSKHSLISALIYIKKYFYKIREFEFEDEELEKDFKLFIFINAYIISKHHGNLDEFYKFIGVDGKSSRLKEITGAIRGNYEILKPILEDGLSEEELCKGLNYKNAMSNTRSRIDEKDNKESSIAIYIYAKLLYSSLVSCDYYSTSQYMSDSKMNSFGSTEDPAGYDKIFEETELTKIIRKYEKDSYGKRDDFSDEKNINVMRSEMFLDAERKYIENKDKRVYLLEAPTGSGKSNAAVNLSLKMMKEGFKKLYYVYPFNNLVEQNRESLDKIFKNTALENDIAVVNSLEEIVVNETKDEDICNKYQRALLDRQFLNYPFILTTHVSLFDTLFGDTAASCFGFIQLIDSVIVFDEIQSYKSTIWEEIIQFLYTFSEILNMKIIIMSATLPDLTKLIGEKGYSVELIDDREKYFSHKLFKNRVEVSYELLSEEIEKDDLDKVLFEHISDNLKKYDKIMIEFIKKQSAMDFYNMFIEENEIDGLNIALMTGDDNIHERKKIINEVKAESGKILLIATQVVEAGVDIDMDIGYKDTSKIDSEEQFMGRINRSAKKNNSIVYFFNKDKADDIYRNDIAVKYNLTIEKNEEMRKALMNKEFSKYYSEIIKFIREKNKNLYEGTNKFFKNSVGKLNFNDVKNRMKLIDYSKKRQRIFLNRTIPNDNGNMLVGKDVWNDYKKLLLGYEYYNEEGEKVSKELDYAQWKVELSRINKKMNYFIYEINDVNGNEYNDSIGDILYFEDGEDYIKNDKLDREKFSNEQLFY
>NZ_CP036523.1|WP_006441124.1|2502376_2503126_-|type-I-B-CRISPR-associated-protein-Cas5
MKVLKFKLSGNTAFFKNNEVNAYYYFTYGNIHKVALLGMLGAIMGYGGYQKQQNENAIYPEFYDRLKDLKIAIEPLTEVGQFAKKIHTFNNSVGYASDENGRNLIVKEQWLEEPAWNIYFLIDSEVGEELAEKIINRECVYIPYLGKNDHPANIEDVEIIENVEKVSDKNLIINSLFKYEERESYMIEDDDEEEEEDLKIIYRYTEYLPIGLDEKNNMYELAKFVFTNERIIKFNSQVFKAGEKNIVFY
>NZ_CP036523.1|WP_006441123.1|2503129_2504092_-|type-I-CRISPR-associated-protein-Cas7
MAKLARRVYGVLGVSAINAMMNADFNGYPKSLANGTIYASDKSLKYPIKKTWQLEGKNVLYIKTMRMEAGKKGEVIIVPRALKEGFENIFGIEDLSKVKDVNEILKNLFSAIDVKNFGATFAEKGNNIAITGAVQIGQGMNKYESTSIEEQQILSPFRDPKAKPGKDDQDDEIAKNSTLGTKIMTDEAHYFFPFSINPNVYKEFEEMGVTEGYTEEDYLEFKRAALSAMTAFDTNSKSGCDNEFGLFIETDNKTYLPNLDKFIEFEKAEKNTIRVNIKDLISGIEDKINSMEIYYNPLTTNIETDLEGVKMFNIVTQKEV
>NZ_CP036523.1|WP_040410738.1|2504107_2505907_-|hypothetical-protein
MLKDLVDVYNNMKKNCENPERLILDGYVPKNGTYVLVEVDREKNNFEIQEPVEINNTKKNDEEDVVIRDYDYIKFLDYNSSLISMNKPIDSKKKIHSNNYLTLFFKKETITTDDEKKKLDDDVIVGYYALLKDIEKKYTNKKAKESYESAAKDLEEIDLELLEKIENWVLKNKFWENEKYNLKDKNYFKIFFVLKDDEKRTKELYENEGKRYLLPNIYNKNDYNVKIEDEVIGLSGNNMGMNSKKPFLENKTRKTKVPILITQEEALNYSELFKLISNMLSEKKYNIYIDYDRNTIKGYRNGEIPDQEIKSGAYIMAQIGQNEPEIQHFDTISNFGDKTCKSFQYNQVIKTNLEDDKYEYITYERYSSIQRLINGVLFENKLIENYFRGSSDIKVKNLKIKEELLMTRDIYLNWFYKGVTNGICNTLDKSILKIIKANILEGKIIAAKKQMNLRYSLISYFTNNKKEEELMEEIREYLIEKILLEKEEQDNWDIENDDVYSYLVGQIVSGLLSFSKAKTVPASSINQFLNTDNDKIIKNKLIRLYEKYNYSIDARYYNRMSSVLGKVLRYEVKNKINKNLLLAGFLDSKIFFMKKEENK
>NZ_CP036523.1|WP_170239666.1|2505939_2506617_-|CRISPR-associated-endoribonuclease-Cas6
MLKVYTLQEINRSDEKEKSGYFIDQTLLSDGYFKKFHESVGFKYYSFNTLYPFKNEKYEKGNVYELKIRTVDYNLANFLLENLPNTTTKELKGLEARARILEERPIEKLYSLSPIIVKTAQKKYWKECMNVEEYMERIKINLIKKYNSFFNTKIDENFELFTSIVIKNKCPIGFKYKGIKLPGDKIELTIAVNEQAQKLANFAQAVALGDLGPRGAGFVNAKYIK
>NZ_CP036523.1|WP_006441120.1|2507152_2508340_+|pyridoxal-phosphate-dependent-aminotransferase
MKLATKLDTLTPSFTIGISSKVKEMKANGIDVLNLSIGEPDFTVPEKAKAYGKKSLDEDCTKYDLVPGLKILREEIVKKLKRENNCDYTIDEIVLSSGAKNSITNALLAVTNPGEEVLIPKPYWVSYPEMVKLTGAVPKFIDTKRENGFKLTKEELEAAITEKSKMLILTNPSNPTGNVYTKEELIDIVNVCIEKEIFILADEIYERICYVDGFTSVASLSEEAKDITITINGFAKSVAMTGLRLGYTASNKEVAKAMSSIQGHLVSHPCLTAQYIGYGALVECEEDIKHMVSVYKSRRDMLVERLDAIDHVSYIQPSGAFYMFIDLSEVAEKYDWKESFSIEFCEELLNKYHVAGVPGIAFGLDNYMRISYACNEETFMTAMDRLEEFVKAIFA
>NZ_CP036523.1|WP_006441119.1|2508419_2509325_-|nucleoside-hydrolase
MKKVIYDCDNTMGLDNRDIDDGLALVYLVENKNMELLGVCTTYANDSLEYVHKQTLELVEDLGINLKVYKGRGKFEMNDYTGFGYKRFEDDGNFESNEAAKFIVEMANKYPNEIDLLATGSMQNLYDAYMIDNEIGEKLSSVVLMGGITGDLYFGDKIMKELNFSVCPKGAEVAIKKYKNVSILTGNRCMDVEFGTNELDKVKALGSNIKNEFIIQKIEKWMREFKEKYNYDSIVLWDVIAAIYLMNPDMFRDDFMSVVSTEEDLFEGRLVEGESAARINIPVVLDDKKVNDEMIKVVFER

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP036523_2	2.1\|2369027\|22\|NZ_CP036523\|CRT	2369027-2369048	22	NZ_CP026305	Streptomyces lunaelactis strain MM109 plasmid pSLUN1, complete sequence	114356-114377	2	0.909
NZ_CP036523_2	2.4\|2369168\|25\|NZ_CP036523\|CRT	2369168-2369192	25	NZ_CP007796	Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence	229505-229529	3	0.88
NZ_CP036523_2	2.3\|2369123\|25\|NZ_CP036523\|CRT	2369123-2369147	25	NZ_CP009113	Rhodococcus opacus strain 1CP plasmid pR1CP2, complete sequence	56044-56068	4	0.84
NZ_CP036523_2	2.4\|2369168\|25\|NZ_CP036523\|CRT	2369168-2369192	25	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	1927412-1927436	4	0.84
NZ_CP036523_2	2.4\|2369168\|25\|NZ_CP036523\|CRT	2369168-2369192	25	NZ_CP048637	Rhizobium oryzihabitans strain M15 plasmid p5, complete sequence	14763-14787	5	0.8
NZ_CP036523_2	2.4\|2369168\|25\|NZ_CP036523\|CRT	2369168-2369192	25	NZ_CP048637	Rhizobium oryzihabitans strain M15 plasmid p5, complete sequence	1356-1380	5	0.8
NZ_CP036523_2	2.4\|2369168\|25\|NZ_CP036523\|CRT	2369168-2369192	25	NZ_CP012886	Mycobacterium chimaera strain AH16 plasmid unnamed1, complete sequence	349049-349073	5	0.8
NZ_CP036523_2	2.4\|2369168\|25\|NZ_CP036523\|CRT	2369168-2369192	25	NZ_CP048638	Rhizobium oryzihabitans strain M15 plasmid p6, complete sequence	3184-3208	5	0.8
NZ_CP036523_2	2.2\|2369069\|34\|NZ_CP036523\|CRT	2369069-2369102	34	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	67311-67344	8	0.765
NZ_CP036523_2	2.2\|2369069\|34\|NZ_CP036523\|CRT	2369069-2369102	34	NZ_KU140623	Sinorhizobium sp. M14 plasmid pSinB, complete sequence	224778-224811	8	0.765
NZ_CP036523_2	2.2\|2369069\|34\|NZ_CP036523\|CRT	2369069-2369102	34	NZ_CP032676	Rhodococcus rhodochrous strain ATCC BAA870 plasmid pNit, complete sequence	168700-168733	8	0.765
NZ_CP036523_2	2.2\|2369069\|34\|NZ_CP036523\|CRT	2369069-2369102	34	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	979907-979940	8	0.765
NZ_CP036523_1	1.8\|1452219\|38\|NZ_CP036523\|CRISPRCasFinder,CRT,PILER-CR	1452219-1452256	38	NC_022883	Enterococcus mundtii QU 25 plasmid pQY082, complete sequence	55427-55464	10	0.737

1. spacer 2.1|2369027|22|NZ_CP036523|CRT matches to NZ_CP026305 (Streptomyces lunaelactis strain MM109 plasmid pSLUN1, complete sequence) position: , mismatch: 2, identity: 0.909

atcgtggtgatggtgttctcca	CRISPR spacer
atcgaggtgatggtgttctccg	Protospacer
**** ****************.

2. spacer 2.4|2369168|25|NZ_CP036523|CRT matches to NZ_CP007796 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence) position: , mismatch: 3, identity: 0.88

gtcgtgatcgtgatgatgttctcca	CRISPR spacer
ggcgtgatcgttctgatgttctcca	Protospacer
* *********  ************

3. spacer 2.3|2369123|25|NZ_CP036523|CRT matches to NZ_CP009113 (Rhodococcus opacus strain 1CP plasmid pR1CP2, complete sequence) position: , mismatch: 4, identity: 0.84

gtcgtgattgtgatgatgttctcca	CRISPR spacer
ctcgtgattgtgaagttgttctccg	Protospacer
 ************ * ********.

4. spacer 2.4|2369168|25|NZ_CP036523|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 4, identity: 0.84

gtcgtgatcgtgatgatgttctcca	CRISPR spacer
cgcgtgatcgtgctgatgttcttca	Protospacer
  ********** *********.**

5. spacer 2.4|2369168|25|NZ_CP036523|CRT matches to NZ_CP048637 (Rhizobium oryzihabitans strain M15 plasmid p5, complete sequence) position: , mismatch: 5, identity: 0.8

gtcgtgatcgtgatgatgttctcca	CRISPR spacer
atcgtgatcgtgatgatgtcctatc	Protospacer
.******************.** .

6. spacer 2.4|2369168|25|NZ_CP036523|CRT matches to NZ_CP048637 (Rhizobium oryzihabitans strain M15 plasmid p5, complete sequence) position: , mismatch: 5, identity: 0.8

gtcgtgatcgtgatgatgttctcca	CRISPR spacer
atcgtgatcgtgatgatgtcctatc	Protospacer
.******************.** .

7. spacer 2.4|2369168|25|NZ_CP036523|CRT matches to NZ_CP012886 (Mycobacterium chimaera strain AH16 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.8

gtcgtgatcgtgatgatgttctcca	CRISPR spacer
gtcgtgatcgtgatgatgatcgtgg	Protospacer
****************** ** . .

8. spacer 2.4|2369168|25|NZ_CP036523|CRT matches to NZ_CP048638 (Rhizobium oryzihabitans strain M15 plasmid p6, complete sequence) position: , mismatch: 5, identity: 0.8

gtcgtgatcgtgatgatgttctcca	CRISPR spacer
atcgtgatcgtgatgatgtcctatc	Protospacer
.******************.** .

9. spacer 2.2|2369069|34|NZ_CP036523|CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.765

atcgtggtcatgttcgtgatggtggtgttcttcg	CRISPR spacer
ttggagttggtgttggtgttggtggtgttcttcg	Protospacer
 * * * * .**** *** ***************

10. spacer 2.2|2369069|34|NZ_CP036523|CRT matches to NZ_KU140623 (Sinorhizobium sp. M14 plasmid pSinB, complete sequence) position: , mismatch: 8, identity: 0.765

atcgtggtcatgttcgtgatggtggtgttcttcg	CRISPR spacer
gccgtggtcatgcccgtgatggtggtcgtccttg	Protospacer
..**********..************  **.*.*

11. spacer 2.2|2369069|34|NZ_CP036523|CRT matches to NZ_CP032676 (Rhodococcus rhodochrous strain ATCC BAA870 plasmid pNit, complete sequence) position: , mismatch: 8, identity: 0.765

atcgtggtcatgttcgtgatggtggtgttcttcg	CRISPR spacer
cccgcgatgttgatcgtgatggtggtggtcttcg	Protospacer
 .**.*.*  ** ************** ******

12. spacer 2.2|2369069|34|NZ_CP036523|CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 8, identity: 0.765

atcgtggtcatgttcgtgatggtggtgttcttcg	CRISPR spacer
ttggagttggtgttggtgttggtggtgttcttcg	Protospacer
 * * * * .**** *** ***************

13. spacer 1.8|1452219|38|NZ_CP036523|CRISPRCasFinder,CRT,PILER-CR matches to NC_022883 (Enterococcus mundtii QU 25 plasmid pQY082, complete sequence) position: , mismatch: 10, identity: 0.737

gacagaagaagaacaaaaagctgcagaacaacagatgc	CRISPR spacer
atacaagaaagaacaaaaagcagcacaacaacagatgg	Protospacer
.   .*..************* *** ***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

369549 : 375442

Streptococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_006439013.1\|369549_370281_+	methyltransferase domain-containing protein	A0A0B5IWU9	Pandoravirus	1.1e-06	27.4
WP_006439014.1\|370382_371219_+	DNA adenine methylase	A0A1S5PRR3	Streptococcus_phage	1.3e-56	43.8
WP_006439015.1\|371223_372027_+	site-specific DNA-methyltransferase	M1Q227	Streptococcus_phage	1.5e-25	32.5
WP_006439016.1\|372016_372883_+	type II restriction endonuclease	A0A2H4JAL2	uncultured_Caudovirales_phage	2.3e-27	29.8
WP_006439017.1\|372900_374367_+	Eco57I restriction-modification methylase domain-containing protein	A0A1J0F9H0	Only_Syngen_Nebraska_virus	9.0e-08	23.4
WP_040410180.1\|374332_375442_+	DUF262 domain-containing protein	A0A0R6PKN1	Moraxella_phage	6.8e-16	31.1

DBSCAN-SWA_2

1314747 : 1336394

Clostridium_phage(70.59%)

head,terminase,plate,capsid,portal,tail,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_040410575.1\|1314747_1315149_-\|holin	phage holin family protein	M9Q253	Clostridium_phage	2.6e-34	54.9
WP_006440394.1\|1315150_1315720_-	glucosaminidase domain-containing protein	NA	NA	NA	NA
WP_040410462.1\|1315788_1315974_-	hypothetical protein	NA	NA	NA	NA
WP_006440392.1\|1315998_1316385_-	hypothetical protein	S6C455	Thermus_phage	3.7e-17	39.3
WP_006440391.1\|1316401_1316890_-	hypothetical protein	NA	NA	NA	NA
WP_006440390.1\|1316902_1317370_-	hypothetical protein	NA	NA	NA	NA
WP_006440389.1\|1317380_1317857_-	hypothetical protein	NA	NA	NA	NA
WP_006440388.1\|1317868_1318333_-	hypothetical protein	NA	NA	NA	NA
WP_006440387.1\|1318347_1318998_-	DUF2313 domain-containing protein	S6BFJ0	Thermus_phage	8.3e-22	39.0
WP_148881816.1\|1318998_1319964_-\|plate	baseplate J/gp47 family protein	A0A090D841	Clostridium_phage	2.5e-75	46.2
WP_006440385.1\|1320049_1320487_-	DUF2634 domain-containing protein	A0A0A8WJ32	Clostridium_phage	2.2e-42	57.0
WP_006440384.1\|1320486_1320789_-	DUF2577 family protein	NA	NA	NA	NA
WP_006440383.1\|1320800_1322168_-	C40 family peptidase	A0A0K2SUC1	Clostridium_phage	7.2e-84	36.8
WP_006440382.1\|1322178_1322820_-	LysM peptidoglycan-binding domain-containing protein	A0A1V0DZX0	Clostridioides_phage	3.3e-39	40.4
WP_006440381.1\|1322822_1324469_-	hypothetical protein	A0A1V0DZX3	Clostridioides_phage	2.3e-15	39.5
WP_170239659.1\|1324482_1324626_-	hypothetical protein	NA	NA	NA	NA
WP_006440379.1\|1324649_1325102_-	hypothetical protein	NA	NA	NA	NA
WP_006440378.1\|1325159_1325606_-\|tail	phage tail tube protein	NA	NA	NA	NA
WP_006440377.1\|1325610_1326714_-\|tail	phage tail sheath subtilisin-like domain-containing protein	A0A1V0DZX4	Clostridioides_phage	9.3e-66	41.1
WP_006440376.1\|1326713_1327160_-	hypothetical protein	NA	NA	NA	NA
WP_006440375.1\|1327152_1327596_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_006440374.1\|1327597_1327942_-	hypothetical protein	NA	NA	NA	NA
WP_006440373.1\|1327941_1328352_-\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_006440372.1\|1328344_1328608_-	Rho termination factor N-terminal domain-containing protein	A0A090D801	Clostridium_phage	6.3e-05	39.1
WP_006440371.1\|1328625_1329567_-	hypothetical protein	A0A090D825	Clostridium_phage	3.9e-89	51.5
WP_006440370.1\|1329595_1330132_-	phage scaffolding protein	A0A0A8WFU8	Clostridium_phage	9.0e-06	43.1
WP_006440369.1\|1330481_1330691_-	hypothetical protein	NA	NA	NA	NA
WP_006440368.1\|1330704_1332078_-\|capsid	minor capsid protein	A0A090D822	Clostridium_phage	1.7e-69	44.7
WP_148881817.1\|1332067_1333414_-\|portal	phage portal protein	A0A090DBP3	Clostridium_phage	2.2e-117	50.9
WP_006440365.1\|1333428_1334832_-\|terminase	phage terminase large subunit	A0A090EUA8	Clostridium_phage	1.4e-188	71.2
WP_006440364.1\|1334824_1335283_-	hypothetical protein	A0A0A7RTH0	Clostridium_phage	9.9e-46	65.6
WP_006440363.1\|1335470_1335890_-	hypothetical protein	NA	NA	NA	NA
WP_040410569.1\|1335971_1336394_-	DUF1064 domain-containing protein	A0A0A8WFH8	Clostridium_phage	1.1e-35	58.4

DBSCAN-SWA_3

1343635 : 1351909

Clostridium_phage(50.0%)

integrase

attL 1345236:1345250|attR 1359154:1359168

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_006440341.1\|1343635_1344466_-	hypothetical protein	A0A1B1P7G4	Bacillus_phage	1.4e-29	53.7
WP_040410567.1\|1344479_1345094_-	ERF family protein	A0A090D840	Clostridium_phage	1.7e-48	52.2
WP_006440339.1\|1345151_1345673_-	siphovirus Gp157 family protein	A0A0A8WFY3	Clostridium_phage	6.7e-22	39.3
1345236:1345250	attL	NA	NA	NA	NA
WP_006440338.1\|1345854_1346091_-	hypothetical protein	NA	NA	NA	NA
WP_006440337.1\|1346090_1346327_-	hypothetical protein	NA	NA	NA	NA
WP_006440336.1\|1346301_1346658_-	hypothetical protein	NA	NA	NA	NA
WP_006440335.1\|1346737_1346893_-	hypothetical protein	NA	NA	NA	NA
WP_050754664.1\|1346897_1347707_-	phage antirepressor KilAC domain-containing protein	A0A1W6JNH2	Staphylococcus_phage	2.3e-77	63.0
WP_050754663.1\|1347708_1347936_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_006440332.1\|1348107_1348533_+	helix-turn-helix domain-containing protein	A0A0S2MVI1	Bacillus_phage	2.9e-07	28.5
WP_006440331.1\|1348554_1348980_+	ImmA/IrrE family metallo-endopeptidase	D2XR38	Bacillus_phage	7.6e-24	44.7
WP_006440330.1\|1348992_1350573_+	DUF4041 domain-containing protein	X5JAC1	Clostridium_phage	3.7e-100	66.5
WP_006440329.1\|1350775_1351909_+\|integrase	site-specific integrase	A0A0A8WIF9	Clostridium_phage	6.0e-60	35.9
1359154:1359168	attR	NA	NA	NA	NA

DBSCAN-SWA_4

1568296 : 1647259

Clostridium_phage(55.88%)

head,terminase,plate,protease,transposase,capsid,portal,tail,integrase,holin,tRNA

attL 1634312:1634328|attR 1647479:1647495

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148881830.1\|1568296_1568887_-\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_118549764.1\|1569108_1569336_-	hypothetical protein	NA	NA	NA	NA
WP_170239654.1\|1569423_1570683_-\|transposase	IS91 family transposase	NA	NA	NA	NA
WP_006440130.1\|1570786_1572061_-	glucose-6-phosphate isomerase	NA	NA	NA	NA
WP_006440129.1\|1572252_1572459_-	hypothetical protein	NA	NA	NA	NA
WP_006440128.1\|1572546_1574220_-	ribonuclease J	NA	NA	NA	NA
WP_040410431.1\|1574731_1575469_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_083780557.1\|1575560_1576016_-	transcriptional repressor	NA	NA	NA	NA
WP_050754671.1\|1576112_1576379_-	DUF1292 domain-containing protein	NA	NA	NA	NA
WP_006440123.1\|1576552_1576975_-	Holliday junction resolvase RuvX	NA	NA	NA	NA
WP_006440122.1\|1576961_1579181_-	hypothetical protein	NA	NA	NA	NA
WP_006440121.1\|1579185_1579443_-	IreB family regulatory phosphoprotein	NA	NA	NA	NA
WP_040410430.1\|1579472_1582109_-\|tRNA	alanine--tRNA ligase	A0A2K9L3D8	Tupanvirus	2.6e-61	33.1
WP_006440119.1\|1582488_1583562_-\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_040410429.1\|1583597_1584038_-	Fe-S cluster assembly scaffold protein NifU	A0A2H4N7M4	Lake_Baikal_phage	4.1e-33	55.9
WP_040410428.1\|1584137_1585334_-	cysteine desulfurase NifS	H7BUW1	unidentified_phage	2.0e-37	37.3
WP_006440116.1\|1585451_1585919_-	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_040410427.1\|1586008_1587301_-	replication-associated recombination protein A	G3MBE0	Bacillus_virus	2.0e-88	40.9
WP_040410426.1\|1587396_1588182_-	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_040410425.1\|1588486_1590562_-	type I DNA topoisomerase	A0A1V0SB35	Catovirus	2.0e-101	36.9
WP_040410424.1\|1590590_1591712_-	DNA-protecting protein DprA	NA	NA	NA	NA
WP_006440107.1\|1591764_1593321_-	YifB family Mg chelatase-like AAA ATPase	NA	NA	NA	NA
WP_006440106.1\|1593333_1593681_-	YraN family protein	NA	NA	NA	NA
WP_006440105.1\|1593847_1594354_+	hypothetical protein	NA	NA	NA	NA
WP_006440104.1\|1594471_1594717_-	hypothetical protein	NA	NA	NA	NA
WP_118549764.1\|1594953_1595181_-	hypothetical protein	NA	NA	NA	NA
WP_170239654.1\|1595268_1596528_-\|transposase	IS91 family transposase	NA	NA	NA	NA
WP_006440103.1\|1596626_1597643_-	alpha-hydroxy-acid oxidizing protein	NA	NA	NA	NA
WP_006440102.1\|1597737_1598508_-	ribonuclease HII	V5LS49	Emiliania_huxleyi_virus	9.2e-28	41.9
WP_006440101.1\|1598654_1599926_-	branched-chain amino acid transport system II carrier protein	NA	NA	NA	NA
WP_040410423.1\|1600332_1601616_-	branched-chain amino acid transport system II carrier protein	NA	NA	NA	NA
WP_040410537.1\|1602268_1603564_-	branched-chain amino acid transport system II carrier protein	NA	NA	NA	NA
WP_006440098.1\|1604235_1605129_-	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_040410422.1\|1605241_1605595_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_040410421.1\|1605713_1606400_-\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_006440095.1\|1606409_1606928_-	16S rRNA processing protein RimM	NA	NA	NA	NA
WP_040410536.1\|1607019_1607247_-	KH domain-containing protein	NA	NA	NA	NA
WP_040410420.1\|1607270_1607522_-	30S ribosomal protein S16	NA	NA	NA	NA
WP_006440092.1\|1607561_1608923_-	signal recognition particle protein	NA	NA	NA	NA
WP_040410419.1\|1608919_1609288_-	YlxM family DNA-binding protein	NA	NA	NA	NA
WP_006440090.1\|1609509_1610862_-	signal recognition particle-docking protein FtsY	NA	NA	NA	NA
WP_006440089.1\|1610885_1614440_-	chromosome segregation protein SMC	NA	NA	NA	NA
WP_040410418.1\|1614481_1615549_-	radical SAM protein	E3T5G2	Cafeteria_roenbergensis_virus	3.0e-08	26.7
WP_148881831.1\|1615558_1616218_-	ribonuclease III	M1PMQ4	Moumouvirus	1.4e-21	31.8
WP_148881763.1\|1616265_1617588_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.7e-29	35.7
WP_006439318.1\|1617664_1618555_-	YegS/Rv2252/BmrU family lipid kinase	NA	NA	NA	NA
WP_006439317.1\|1618571_1619213_-	lactate utilization protein	NA	NA	NA	NA
WP_006439316.1\|1619313_1619853_-	hypothetical protein	NA	NA	NA	NA
WP_006439315.1\|1619888_1621358_-\|tRNA	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	NA	NA	NA	NA
WP_006439314.1\|1621923_1622721_-	N-acetylmuramoyl-L-alanine amidase	E5G068	Clostridium_phage	2.2e-08	30.3
WP_006439313.1\|1622722_1623136_-\|holin	phage holin family protein	A0A0A7S099	Clostridium_phage	2.8e-31	52.3
WP_006439312.1\|1623234_1623408_-	hypothetical protein	NA	NA	NA	NA
WP_006439311.1\|1623438_1623858_-	hypothetical protein	S6C455	Thermus_phage	5.5e-11	36.5
WP_006439310.1\|1623873_1624440_-	hypothetical protein	NA	NA	NA	NA
WP_148881832.1\|1624450_1624825_-	hypothetical protein	NA	NA	NA	NA
WP_006439308.1\|1624983_1625346_-	hypothetical protein	NA	NA	NA	NA
WP_006439307.1\|1625502_1625826_-	hypothetical protein	NA	NA	NA	NA
WP_006439305.1\|1625982_1626456_-	hypothetical protein	NA	NA	NA	NA
WP_006439304.1\|1626455_1627049_-	YmfQ family protein	J9QD29	Clostridium_phage	9.2e-28	42.4
WP_006439303.1\|1627041_1628097_-\|plate	baseplate J/gp47 family protein	A0A090EU53	Clostridium_phage	1.0e-77	44.9
WP_006439302.1\|1628089_1628521_-	DUF2634 domain-containing protein	J9QE34	Clostridium_phage	1.3e-31	52.3
WP_006439301.1\|1628520_1628823_-	DUF2577 family protein	NA	NA	NA	NA
WP_006439300.1\|1628832_1630524_-	C40 family peptidase	A0A0K2SUC1	Clostridium_phage	3.0e-124	45.9
WP_006439299.1\|1630524_1631160_-	LysM peptidoglycan-binding domain-containing protein	A0A0A8WJR4	Clostridium_phage	4.9e-35	38.8
WP_006439298.1\|1631175_1632924_-	hypothetical protein	A0A0K2SUF9	Clostridium_phage	2.3e-95	54.3
WP_006439297.1\|1632924_1633074_-	hypothetical protein	NA	NA	NA	NA
WP_006439296.1\|1633097_1633481_-	hypothetical protein	A0A0A8WIB2	Clostridium_phage	9.5e-18	41.7
WP_006439295.1\|1633497_1633944_-\|tail	phage tail tube protein	A0A0A8WF55	Clostridium_phage	1.5e-43	62.8
WP_006439294.1\|1633957_1635031_-\|tail	phage tail sheath subtilisin-like domain-containing protein	A0A0A8WJR2	Clostridium_phage	1.3e-88	47.5
1634312:1634328	attL	NA	NA	NA	NA
WP_006439293.1\|1635033_1635444_-	hypothetical protein	A0A0K2SUF6	Clostridium_phage	2.4e-19	42.3
WP_006439292.1\|1635447_1635900_-	HK97 gp10 family phage protein	A0A0A8WIW8	Clostridium_phage	4.4e-38	54.1
WP_006439291.1\|1635892_1636231_-\|head	phage head closure protein	A0A0K2SU81	Clostridium_phage	2.1e-24	55.4
WP_006439290.1\|1636230_1636527_-\|head,tail	phage gp6-like head-tail connector protein	A0A0K2SUB5	Clostridium_phage	2.4e-16	43.2
WP_006439289.1\|1636602_1637805_-\|capsid	phage major capsid protein	R9TQG7	Paenibacillus_phage	3.9e-17	27.8
WP_050754633.1\|1637794_1638523_-\|protease	Clp protease ClpP	A0A0A8WFA4	Clostridium_phage	8.9e-57	52.1
WP_006439287.1\|1638515_1639688_-\|portal	phage portal protein	J9QE83	Clostridium_phage	5.5e-141	64.6
WP_006439286.1\|1639700_1641386_-\|terminase	terminase large subunit	A0A290GJW3	Caldibacillus_phage	3.7e-231	68.6
WP_006439285.1\|1641386_1641746_-	hypothetical protein	A0A290GJQ7	Caldibacillus_phage	2.7e-30	62.3
WP_006439284.1\|1641904_1642201_-	HNH endonuclease	R9TNN2	Paenibacillus_phage	9.9e-23	53.7
WP_006439283.1\|1642390_1642939_-\|integrase	site-specific integrase	E2ELN7	Clostridium_phage	1.1e-59	61.0
WP_006439282.1\|1642925_1643081_-	hypothetical protein	NA	NA	NA	NA
WP_006439281.1\|1643187_1643706_-	hypothetical protein	NA	NA	NA	NA
WP_006439279.1\|1643968_1644124_-	hypothetical protein	NA	NA	NA	NA
WP_006439278.1\|1644123_1644513_-	hypothetical protein	NA	NA	NA	NA
WP_006439277.1\|1644512_1644794_-	hypothetical protein	NA	NA	NA	NA
WP_006439276.1\|1644806_1645208_-	single-stranded DNA-binding protein	E2ELN0	Clostridium_phage	1.9e-32	51.8
WP_006439275.1\|1645218_1645593_-	hypothetical protein	NA	NA	NA	NA
WP_006439274.1\|1645607_1645922_-	hypothetical protein	NA	NA	NA	NA
WP_148881873.1\|1645936_1647259_-	AAA family ATPase	A0A191ZDG5	Pseudoalteromonas_virus	5.1e-18	22.9
1647479:1647495	attR	NA	NA	NA	NA

DBSCAN-SWA_5

2381541 : 2391961

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148881850.1\|2381541_2385327_-	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	4.8e-29	23.3
WP_040410730.1\|2385358_2386609_-	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_006441093.1\|2386628_2388164_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	2.1e-63	43.6
WP_006441092.1\|2388156_2388753_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.2e-21	37.0
WP_006441091.1\|2388746_2389823_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	1.0e-61	39.2
WP_006441090.1\|2389994_2391350_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.2e-45	29.5
WP_006441089.1\|2391487_2391961_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	3.3e-28	49.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP036523

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection