CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP041646	Rhodococcus hoagii strain WY plasmid pWY, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP041647	Rhodococcus hoagii strain WY chromosome, complete genome	2 crisprs	csa3,WYL,cas3,DinG,cas4,DEDDh,c2c9_V-U4	0	1	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP041647_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP041647_1

3348517-3348598

Orphan

Consensus_repeat	Method
CGGCAAGGGCCTGCAGATGAAGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP041647_1

>merge|NZ_CP041647|1|3348517-3348598|CRISPRCasFinder
CGGCAAGGGCCTGCAGATGAAGGGCCTCGCCAAGGCTCCCGGCGCGAAGGCACCGGGCGGCAAGGGCCTCCAGATGAAGGGC

>NZ_CP041647|1|1|3348517-3348598|CRISPRCasFinder
CGGCAAGGGCCTGCAGATGAAGGGC	CTCGCCAAGGCTCCCGGCGCGAAGGCACCGGG
CGGCAAGGGCCTCCAGATGAAGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP041647.1\|WP_084846881.1\|3349955_3350579_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041647.1\|WP_084869980.1\|3355000_3356323_+\|YibE/F-family-protein	unknown	unknown	gnl\|CDD\|377940
NZ_CP041647.1\|WP_084869976.1\|3339461_3341963_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP041647.1\|WP_143524900.1\|3334897_3337381_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041647.1\|WP_005517683.1\|3328533_3329430_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182137
NZ_CP041647.1\|WP_084869982.1\|3356333_3357512_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|198373
NZ_CP041647.1\|WP_084866225.1\|3332906_3334751_-\|Isoniazid-inducible-protein-iniA	unknown	unknown	gnl\|CDD\|206739
NZ_CP041647.1\|WP_022597906.1\|3358090_3359524_-\|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl\|CDD\|349772
NZ_CP041647.1\|WP_013417187.1\|3344999_3345635_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041647.1\|WP_084844644.1\|3350680_3352630_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP041647.1\|WP_084870266.1\|3329553_3331362_+\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223839
NZ_CP041647.1\|WP_005517658.1\|3353454_3354717_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|181738
NZ_CP041647.1\|WP_143524901.1\|3359586_3378309_-\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|237108
NZ_CP041647.1\|WP_022597898.1\|3352678_3353101_+\|TIGR03668-family-PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|132707
NZ_CP041647.1\|WP_084869968.1\|3331362_3332910_-\|Isoniazid-inducible-protein-iniC	unknown	unknown	gnl\|CDD\|206739
NZ_CP041647.1\|WP_084869985.1\|3357607_3358123_+\|low-molecular-weight-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|319972
NZ_CP041647.1\|WP_084869989.1\|3378516_3380364_+\|DUF4012-domain-containing-protein	unknown	unknown	gnl\|CDD\|379067
NZ_CP041647.1\|WP_064059149.1\|3343583_3344900_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|365866
NZ_CP041647.1\|WP_084869974.1\|3337676_3339458_+\|Hsp70-family-protein	unknown	unknown	gnl\|CDD\|212667
NZ_CP041647.1\|WP_005517675.1\|3342045_3343422_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP041647.1\|WP_084869976.1\|3339461_3341963_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.94835e-14
NZ_CP041647.1\|WP_005517683.1\|3328533_3329430_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|182137	PRK09906, PRK09906, DNA-binding transcriptional regulator HcaR; Provisional.	1.7938e-29
NZ_CP041647.1\|WP_084869982.1\|3356333_3357512_-\|hypothetical-protein	gnl\|CDD\|198373	cd07805, FGGY_XK_like_2, uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases. This subgroup is composed of uncharacterized proteins with similarity to bacterial D-Xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17), which catalyze the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. The presence of Mg2+ or Mn2+ is required for catalytic activity. D-XK exists as a dimer with an active site that lies at the interface between the N- and C-terminal domains. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	5.73562e-06
NZ_CP041647.1\|WP_064059149.1\|3343583_3344900_+\|hypothetical-protein	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	0.00165803
NZ_CP041647.1\|WP_084866225.1\|3332906_3334751_-\|Isoniazid-inducible-protein-iniA	gnl\|CDD\|206739	cd09912, DLP_2, Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins. The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.	1.61299e-23
NZ_CP041647.1\|WP_022597898.1\|3352678_3353101_+\|TIGR03668-family-PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|132707	TIGR03668, Rv0121_F420, PPOX class probable F420-dependent enzyme, Rv0121 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	9.27857e-50
NZ_CP041647.1\|WP_084844644.1\|3350680_3352630_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	7.96362e-56
NZ_CP041647.1\|WP_084870266.1\|3329553_3331362_+\|penicillin-binding-protein	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	3.91244e-54
NZ_CP041647.1\|WP_143524901.1\|3359586_3378309_-\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NZ_CP041647.1\|WP_084869980.1\|3355000_3356323_+\|YibE/F-family-protein	gnl\|CDD\|377940	pfam07907, YibE_F, YibE/F-like protein. The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE and YibF. Most of the members of this family are annotated as being putative membrane proteins, and in fact the sequences contain a high proportion of hydrophobic residues.	9.45677e-84
NZ_CP041647.1\|WP_084869968.1\|3331362_3332910_-\|Isoniazid-inducible-protein-iniC	gnl\|CDD\|206739	cd09912, DLP_2, Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins. The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.	4.77446e-15
NZ_CP041647.1\|WP_084869985.1\|3357607_3358123_+\|low-molecular-weight-phosphatase-family-protein	gnl\|CDD\|319972	cd16344, LMWPAP, low molecular weight protein arginine phosphatase. Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.	2.16712e-36
NZ_CP041647.1\|WP_084869989.1\|3378516_3380364_+\|DUF4012-domain-containing-protein	gnl\|CDD\|379067	pfam13196, DUF4012, Protein of unknown function (DUF4012). This is a family of uncharacterized proteins found in archaea and bacteria.	1.44748e-57
NZ_CP041647.1\|WP_005517658.1\|3353454_3354717_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0
NZ_CP041647.1\|WP_084869974.1\|3337676_3339458_+\|Hsp70-family-protein	gnl\|CDD\|212667	cd10170, HSP70_NBD, Nucleotide-binding domain of the HSP70 family. HSP70 (70-kDa heat shock protein) family chaperones assist in protein folding and assembly and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). Some HSP70 family members are not chaperones but instead, function as NEFs to remove ADP from their HSP70 chaperone partners during the ATP hydrolysis cycle, some may function as both chaperones and NEFs.	7.37692e-38
NZ_CP041647.1\|WP_022597906.1\|3358090_3359524_-\|polysaccharide-biosynthesis-tyrosine-autokinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	9.76955e-71

>NZ_CP041647.1|WP_013417187.1|3344999_3345635_-|hypothetical-protein
MKLRKFAATSALVIAAMGVGAGTAYAQPAPAQDGVGYQAHIDGRSVVTVLDAGGFHVTSDGRFVEIRNDAGQVIQTLPLTYRLGDREFSIAPVVEGRQLTLTPETDPAKATMADVAGPTLPPLPIDLSMLDKLAEGVDSAVTVGSLIGTVIGAVIGCVGGGSTGPAACLGGIATGATAGGIIGTIVAAGPVLAYNGWQVYQTMNTPAPAAG
>NZ_CP041647.1|WP_064059149.1|3343583_3344900_+|hypothetical-protein
MRSSLARRAAVFGSAALLLVAPAVAQAAPGPDTSGVSDQAAHLPIQLIDALQRDLQLTPGQYLERSEAAQKLAEFAAMAGVEFPDAFGGTWLDTAGVPVVGVAGPDGAALRDAAAQAGFTPQEVARSAHRLDADHTALTDWIATLPPEIANLVNGVSVDIAANTVVLRTENAAEPLLDLLPPGLREAARVVLGPALGSLEPAPTGLQTAYFSTDALLGGDSYEARSGGNGLRCSLGFNAVDQAGAPVNISAGHCDPSPASAGTPSASVANTMVGGLTGPTVGTFEKTVLRGMDYSIIRPNRTSASLLANNMVRVPNAEALRITGTANPVVGAPVCKAGSTTGFNCGVVTNVGRSITVGDRVIDNGFDTDICALRGDSGGPVVTGTQALGISSASNLAAVATCDATAVQQATGGMGPMLSATPINSILGANPGLAVRTS
>NZ_CP041647.1|WP_005517675.1|3342045_3343422_+|hypothetical-protein
MRIPLAPRAAVHSFARRVAVVGSSALLVLVPLSASAQAEPAASGSQVSQLSADQLPDELVEAITRDLKITPQEYLDRAARAQELVSYADDFRAERPHEFAGAWMALDGHPVVSVTTAEAALTAARDGYRTQMAAVSSEGLEKSLADFNHWVTELPREISSQIGRATVDVLNNQIVVDVANSPVGRALDLPTLLANIKVQVQSFGPVPVASGPLGGDTYITSPQRLVDTPEGGISVCSFGFNGVDRGGNAVNISAGHCDPAPGRNAAVFLPNRANVPDSLEVGRFARSEVGDVDGLDYSLIRLNDAGVRAGLDRPVIRGAGGSALTVTGTAVPVVGAPICKSGQTSSFTCGVVTAERVEALLAVAPNDIRVVRGFSGTACTLGGDSGGAIVTGTLALGITSGSNSTDAPSCGEANIVYAFDGGASNLGIPIQSILDSANATSGGGLGAGLTVRTGTAAH
>NZ_CP041647.1|WP_084869976.1|3339461_3341963_+|LuxR-family-transcriptional-regulator
MRTGPTTSPPGADVLAGVRGAQGLLDTADSDPSALVLVRGRSGSGKSLVLNVIREHLIAHGHDVVTTVAAAETGDAVLVIDGAHTLPADDLAALHRLVQRNDRGVVVAVEPRPHDPALCALGTTMQTLGSVFDLGALTPADIADRARARGIEPTPSLARSLHEWTGGALTHVDAGLGAARHGEAGVRAAVIAHLQDVLQHLDGDVVAALALHLYGGGTDAGDLAPALDISPAQAQALADRVRASSVVTRSGSVLPLARQLLTSAVGVTRLRDLQSRLLATRLDAGTLDTRTACTLAESGLDDPRLAEFLCTRAHSADPSEAYTIYDCAILAGADADALALHRCEAGALSGNLDTAHALADALLTRADDLDPAEVCAAVRISSSIAAQRGELGHSADLYEWLGPDRAGVDAPIAATVLLAAGRPEPAEAMLARGRQGPPTSAAAGTALLADGLAQSIAGSGAVAMNSLTRAMAMLSSSARSRILPDTAPAVTALLCLHSGELAHAEAVLRQALELDPIAGITRSRHLVLSAWTAMIGGDLAGAGTILDGLPTDRALPAREAFFLHGLRIGLARRQGDVGALQREWTQAQPVVAGYSADLFGLLPLGELWLAAVRLGDEQRILHLVEQAQDLLVRLGEPALWGATLHWYGVQAAILGENPAALLPHARALAASAEVSSYAAGLAAAGRVWLRVLREEAESAEVEAAARTLDRIGLPWDGARLAGEAALRVSDTRGATALLQVARSLRGAAAAQSGGEITATDPAVGTLTDREADVAELLVLGLTHREIGARLYIAPKTVEHHVARIRRRLGANSRSELLSMLRALGHGGPETSAS
>NZ_CP041647.1|WP_084869974.1|3337676_3339458_+|Hsp70-family-protein
MDMTAGLGIAVGTANSDAAVTRAGDVGEDGTASVIASRSTIVQLSPDGTATLGSSGTGRAGLTGFVERVADPVGLLGPDGRAHSGEDLFAAAVTCLVDEVRADTESVPDERTPIVVTHPTPWNSHTVRALESALERIGLPPVILASEATACLRWLESARGPQDDGVVVLYDLGDASLDVSVMRTGAEAGLLGRTLRSEDVTGAQFDHLVTRHVLDDLTGRTPGFDPFDPAVLEALTMLRRNCSAAKEALSTDTEAVIPVALPDLETDVRLVRSELEDLVRAPLTTSLDLIREALRSADVEPGDVHHVLLAGGGGAIPLLAELVSSELGMTVVAAPNPAHTAALGAALLAADAEAHVAAPAVPTAPTGITRGSDSTEPLTPVFPSRLHSTRSGTNVRRRIAIIAASAAAIGVLAAGGLSIGTAADPAPEQSTPPASSVPLAENAATGAGPTGEGSPTGTVTVVGSTGGNSTNPATVAARGGSTATGVDPTGRALPQGVASPAPFSEAAPAPTADNPAPGETPTQPVYTPPPAAGGGTAPAPVQGPSPAQIGTGFGNAAEGVGNGVGAVLNGVGGVVGGVVGAVVDPVTGLLIGK
>NZ_CP041647.1|WP_143524900.1|3334897_3337381_-|hypothetical-protein
MASNAVLDFILRLLRDEEAAAAYCANPQASLAAAGLGDLCHADIAAVAPMVAESGLFGSAAGDLGAILAAGTTAAGTIGATAGGGLGLGGGLGGSAGLGLGAGAGLGLGAAAGGGFTGDFDFGGDIAAALGAALAAGGSIGAQLGAALGGAFEAALGLGGGLDLGGLADIGGSIDLGGALATALGGVLDVNGSLVTDLGAALNAAFAGVGSLDLDGLLSVDGGLSAALESAFGIGGALGGELGAALGALLGAAVEAGAELGGGLGAGFDAALDSALALGGSLGGALGGDLAAQLGTSLSGLLESALSIGGSIGGDLGAALGGALELGGMIDIADLVNIDGALDLGASLGALLGGSLGVDGALTTELAAALGAALDGLGSLDLTGLLATGGGLTAALESAFGIGGDLGAQLGAAFGGVLDGVVEAAGGLGGSLETALGGALGIGGDLSAALNGALESALSVGGRLGTELAGNIGGDLTAALSGALESVLAAGGSVGADLGAALGGALEGGIGGSLDLDGLIGAGGDLGAAISAALGSALDVDGALTTTLGTALGSALELGGSLEVGAGADLGGLLEGAFGVGGSAGADLGAALGGVLGGGLESGGSLDLGSVLAGDGGFGTELGGALSGLLGAGGSLGGDLGAALDAAIGAGGGLGSTVDPGDQVGGGLGSTGDLGAGLGGGLDLGGNILGDVSGALDGALGGAVDAATTAIGNAQIGGDFGSSAGFDAGVDTGLDTGFETGVGAATGEGVAGTGDIVADLTGGVNSALQGALDAAGNAWSSIDVDAFGSGQSDAGLFANGLGDLGGHIDPVVVDPAAALDPGHDLLP
>NZ_CP041647.1|WP_084866225.1|3332906_3334751_-|Isoniazid-inducible-protein-iniA
MDNVGSATSESALTSLLDRTSEIASSAGRADLVDRLAVVRRRVVDPRFRVVVVGQLKQGKSQFVNSLLNLSVCSVGDDETTAVPTVVQHAEQASAELVLAEPGGETRRVEVPLAELDSVTPSTPLAQGREVLRLEVGVPSPLLADGLVFVDTPGVGGHGNPHAAATLGLLPGADAVLVLSDASQEFTEPELAFLRQVTGLCPAVACLITKTDLYPHWRRIVEADAGHLTRAGIDVPLLPVSSLLRSHAMRLDDRSLHDESGFAALYDFLRERVVDHAAGGLRRAVSLDVHAVVEHLMLSLGSELAALRDPAKGAAAVAELQRAKAVTEELQKKTSRWQQTLADGIADLASDIDHDLRDRLRQVTREAERAVDECDPGKEWDELGEWLEQQIAQSVGDNFVWAHERALWLAEVVAEHFADAGTVELPHLDVGDLDSVLDPVAALSDLESGRIGIAQKVLVGMRGSYGGVLMFGLITTLMGMTLLNPISVGAGVLLGTKAYRDDRETRVVKRRADAKVAIRRFTDDVSFQVGKESKDRLRLIQRLLRDHFTAIAEQTLRSLGDSLRAAQEAAKVESTGRTRRAGEVEQQMAVLETLKGRAAQLFPVDSAENEELSA
>NZ_CP041647.1|WP_084869968.1|3331362_3332910_-|Isoniazid-inducible-protein-iniC
MTAAMTLGRARDLIAAAKAAYSDNPEARAQLAECAARLEEPLRVALAGSLKAGKSTLLNAFVGQDIAPTDATECTRVVTWYRSGTTPTVTARYDGNASANVAVRRHEGRLTFDLGDLTADRVDRLDVEWPASALAQTTIIDTPGTSSLSKDVSARTFRMLTPENAVSGADAVVYLLRSLSASDVQFLGRIGAHVGGESGPLGVVGVVSRADEVGAGRADAMMSAQEVAARFTDELELTGLCQAVVPVAGLLALGARTLRQSEFAAFEALARVPDADLQLAMLSADRFCRDDAALPVDAAMRRQLADRFGLFGIRLAIMLIRLGVNDSPGLAAELVARSGLDELRQVIDVQFGQRAEQLKTHSALVALERVLTAHPSDATTHLLDEVGRLLADVHGFQELRMLGRLRSAETGLSAEDLTELQRLIGGFGIDPAQRLGLAADASIEDGREAGLTAVRKWRERAAHPLVDQFTARACRVAARSAEGVLADLGGVGGAGGYGGAMRLDLDTGSVRVTPA
>NZ_CP041647.1|WP_084870266.1|3329553_3331362_+|penicillin-binding-protein
MTPIGTNPVGPVGWRRGALVLSAALTLTSCGMLGGPDSGEKVAKKFVGALGGADVAAAAALTDDPDGASDVLRRTFDGLGEETDADFTVEHADDTAFTYRSDWDFGGGRTWSYSTTVPLTTADGSRRVDWSASVVNERLRGDQALQYTPVTDTRAVLDANGMALMEPRTVTVVAVESSALVPTVRTRLGALLAKAVPGFELAPPDPGAPTAPDARIDLVTLRQEDVEPIRADLERIPGIHLSDQLRLLTVDREMTSPVVAGLRATWEARQKDSAGWRVQAVDADGGVTGTLAGGDPPAGTAMRTTLDPRLQYLAQRSVDTEPRAAALVALDSGNGQVLAVAQNEPADRSGPIALTGLYPPGSTFKTVTTMAALQSGAVNADSVVDCPGTANISGRVIPNENEFDLGRVPLHTAFAHSCNTTMGRLAVDLPADALQNQAREFGLGVDYVTPGLTTVTGSVPSADTPAQRVEAAIGQGENLASPFGMAMVAAAIARGSAPLPQFIGGETTTADHEPDKLDPAHVRDLKAMMTEAVRSGTATSLSDISGLMGKTGTAEFGDGKHSHGWFVGIRGTVAFAVLVVSGESSGPALDIAGHFLRPLDEQ
>NZ_CP041647.1|WP_005517683.1|3328533_3329430_-|LysR-family-transcriptional-regulator
MNLLLHLEFFVAVAEEQHFGRAAARLGMTQPPLSQGVKKLERELGVTLFHRGSKGVVLTASGHALLPDAIDLVRQAGRFTDTARRRRVQDRTLRVGVMPKVPTALVADVAATLRTFDEPARVEVSIAPSTDLVDQLAAGALDLGVIEHPALVDPLTGTDVVSLPLTLLVPASHPAAAQDPCGLSRLTGLRFASPPRSDGPAAYDLLDDAFARVGADLDVVNAPDDRWALALVAAGQAFALTADRTLDATGVARVRPGDDSIRLRLRCLRSSSADVPDGVLDAVATRIAVYAAGGQVTS
>NZ_CP041647.1|WP_084846881.1|3349955_3350579_+|hypothetical-protein
MLRPEEIADVDGLPVTTVARTVADLARTLPFEQAVVAGDHALHAAGLTSEDVAAAANALPPHAGRQRVHRILAQLDGRSESVGESRSRVLMLREQLPVPECQPNLYSADGDHLGRVDFLFEECAVVGEFDGRGKYGRLVPDGQVPADVVWAEKVREDAIRDAGWQVARWTWDELEVPGVVARRILDAVRRARLSPPPTGRVEHTPRR
>NZ_CP041647.1|WP_084844644.1|3350680_3352630_-|S9-family-peptidase
MTSAAAATAPYGSWISPISAADLAASGHPVDGGRFVGEQVWWSELRPTEGGRTAIRRRGDDGDVVDVLPAPWNARTRVHEYGGGAWTVTGDGVLVFAEFSDQRLYRFDPRTDVAPVPITPLPSVPASDRYGDLAIVGDEVWCVRERHGVSASPVRDICAVPLDGSAAVDAAAVRSIVGGSDFLAYPRLSPDRTYLAWIAWNHPQMPWDGTELRVLRLDTGEVDVLLGGTEESVLQPEWIDDETLRVISDRSGWWNLYRVNLFGEVAPVRPIDADFGAPLWQLGAVWHVELDAGTVLTTRTVGTDTLALLDPATGALRDIELEDISSVQICDTDGRRILLRCGGARVASGLRLLDLGVGTLTDVRLSVDDLPDVEYLPEAQALTFEGPEREVHALVYAPRNPNFVAPEGELPPYVAFVHGGPTAHVAPAVHLVYAYFTSRGIGVVDVNYGGSSGFGREYRNRLRGQWGIVDVEDTVAAVRGLADAGLADPDRLAIEGGSAGGWTVLSALTTSDVFACGVSYYGVAELMEFVKETHDFESRYIDGLIGPLPDAADLYVRRAPVNNVDGLSCPVLLLQGLSDPIVPPSQAERFRTALLDKKIPHAYLAYEGEAHGFRRVETIVSAREAELSFYGQVMGFETPGVPRLELWRP
>NZ_CP041647.1|WP_022597898.1|3352678_3353101_+|TIGR03668-family-PPOX-class-F420-dependent-oxidoreductase
MAPEMPGPLPSRFVDAPVARMATVSADGGPHLVPVVFAAVGDVVFTAVDDKPKSTRRLRRLANIAATGRVSLLVDHYDDDWSRLWWIRVDGTGEVLEPDSDVGVAAIDALVAKYHQYASMRPTGPVIEVRVSGWREWSAS
>NZ_CP041647.1|WP_005517658.1|3353454_3354717_+|pyridoxal-phosphate-dependent-aminotransferase
MEAVSTPEPARPRRPHRALEQSTKLQNVLYEIRGPVHAHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDMIAALPYAQGYSESKGILSARRAIVTRYELVPGFPELDVDDIYLGNGVSELITMTMQALLDDGDEVLIPAPDYPLWTAMTSLSGGTPVHYLCDEQNDWNPDIADIESKITDKTKALLVINPNNPTGAVYSAEVLTQLVDLARRHQLLLLADEIYDKILYDDAKHISLATLAPDLLCLTFNGLSKAYRVAGYRSGWVAITGPKEHAAGFLEGLDLLASTRLCPNVPGQHAIQVALGGHQSIEDLILPGGRLLEQRDVAFERLNMIPGVSCVKPRGALYAFPRLDPNVYEIHDDEKLVQDLLLQEKILMVQGTGFNWPNHDHLRIVTLPWARDLAVAIERFGNFLSSYKQ
>NZ_CP041647.1|WP_084869980.1|3355000_3356323_+|YibE/F-family-protein
MTPELFSRRERSPDRGHGHGHGHGHFDGPAPVGPTAARVVVGLLAAIAIAVVAGAALLWPNKQQIDIPLPFQNAGGGAVTTEAGTVVAQDIAPCGSPSAGRAFPGDPAPAPDVGAGFDCHRSVVTIDSGPHAGTRTLLEIVPGPGQPNLSVGEHLRLVRQTDSSGAPIYSFNDYARGFPLLLIVAAFVVAIVAVARWRGVRALLGLGIAFGVLVVFTLPALLDGKPAMPVALVSGAAILFAVLYLAHGVNLRTSSALLGTLASMLVAAVLSVIAIRMTHLTGLSEQQNADVQAYIQHVSITGLLLAGFIIGSLGVLNDVTITQASAAFEIASMDESATRRTIFASAMRVGRDHIASTVYTLVLAYAGGALPLLLLFSVAGGSMGDVLTGDAVAIEIVRSSVGGIALALSVPLTTAIAALLARPRSAASPSERRRGGRHAR
>NZ_CP041647.1|WP_084869982.1|3356333_3357512_-|hypothetical-protein
MGGVLGVSVGSGFVRIVRHPSPGAHSDAVGLRECRTLVVGDHDPEKLAAEAVGVLLAGDEYAGSADAVAIAYTDESQAAALDAAMRREGVADYRLIPELSAVLEQLAATGLLSGLGAVVVLDLGYTGSTVSVVDVESGTVRATERTALCVAEIGGVVDLADELLTQTGCGADAVVLVGGGATAAAIRERVADLAGLPVVVPEDPELSAASGAALVASSAQAPAESSQHPTAHRRTGHRPGARRRGSRRAVSRRQVRSAGAAGVMLALLAVIGFGLGYGRTLFGSAPDESAGKPVTSSVTIASAPPSAPPSSPVATPESLPVEAPLLAPPAGSRPVANGAPRQSPSAQPAPDPLGTVLDALTGLPNLPPLPPLDALPPLESLPLPPIPQVPGL
>NZ_CP041647.1|WP_084869985.1|3357607_3358123_+|low-molecular-weight-phosphatase-family-protein
MQLLFVCTGNICRSPIAERLASAWSARSDTIDLTVASAGTRAVVGSPMEPKAAQVLSDLGGSPDGFVARQINPAVASSADLVLTMTEEHRDAVLKLSPRHLKRTFTLLEAAHIARALGRGTVAELSAARGSVGQPETTDVPDPIGRSAIVFGDVGSRIESALLDLLPRLDG
>NZ_CP041647.1|WP_022597906.1|3358090_3359524_-|polysaccharide-biosynthesis-tyrosine-autokinase
MEVQDYVRIVQSRWRIIALATVVGLLAALAASLVSTPMYQASSRLFVSTAAGASVNEAYQGNLFSQQRVASYTKLATGEDVLQDAIESRGLDLTPSDLGGRVKATAVPDTVLFDISVLDAKPELARDLADAIAAQLVVKIEGLEAPAAGVEPVARATVVEAAKTPSSAVSPKTKRNVALGFVVGLLAGIALAIVRDRLDNTVKSREVLDDLAGVGLVGSVPFDKEREQKAAIAFHDGYSGSAEAFRELRTNLQFLEVDNPPRVLAITSSLPGEGKTTTAINLSLAIAEAGYSVALVDADLRRPRVAKYLDLIGSVGLSTVLAGQADLDDVLQSSAYPNVSVLASGALPPNPSELLGSTHAEKLIADLRSRFDFVVIDASPLLPVTDAAVLAVKVDGALVVVRHGQTKKEQVTRAVGNLRSVGATVLGTILTMTPSKGKGAYEYSYYYDSDAPVQKIESPATQVSPAPLPVQAGKQVQ
>NZ_CP041647.1|WP_143524901.1|3359586_3378309_-|amino-acid-adenylation-domain-containing-protein
MRPFPLAPAQNALLVAQQLLPNIAMTVAEYLEVRGGIDSQMFIEACDQAARDIGSGTVVLVEVDDEVLQTPVPDIDDRPHFLDLSGADDPHAAALAWMTERTARPIDPFSDRLAEMTLIRLRDDLHYLHYFAHHIVMDGSAAQVLTDRISEVYGALVEGAAPPPTSTAPVEEVWRSVVAYNGSTREASDREYWRERLLDLPPSVSIADRPGPVTTPALRSPGELPAGTLTGSGSGSTMPDVPVIVAGFAAYLSRVLGVGDIVLSLPVSARTTALLRRSAGSVSNVVPLRVRVEPSDTVADLVRRVQIEMTGALRHQRFRYEDMLRELPDGEGRTGLGGVFGPVVNILQFPQTVEFGPVTGELFVLSTGPVEDLSLTVYPGGADRVTRLDFEANPSRYSTESLHRHHSRLLAFLTEFAASGAQLVSDVPFGLPGETAGLTPAAGRPVPGREELLPNVLIRHAGSGGVAVRAAGVEITYAELDARSSALARRLISLGCGPEDAVAVLLPRSIDSVVALWAIAKTGAAYVPVDPELPPLRLAQHLDVVGFAIGRGVELPGSVLLVDPDAPGFSTAPVTDAERLRPLRAENPAWIVHTSGSTGQPKAVVVSHRGIAGLLSTLRTTYAATPDSRVLHVASLSFDASIQEILTAADAGATLVIADGDVVAGDPLAQLIAAEGVTHVVSSPAVLAATPSDAVPTLRMLDSGGEVLPVPVARRWSENRAMVNAYGPTETTILAAVSGRIDDAMLAGATSVPVGRPVDGSSIVVLDPRLRACPPGVVGEVYVLGPSLARGYARDAGSTAGRFVASPFGGGRMYRTGDLARWRANGTLDIVGRVDHQIQLRGIRVEPGEVDALLVTHRGVRAATTAAIDERLVTFACGDGLRPDRLREWLAERLPAHAVPSRVVLLDSLPLTASGKVDRAVLVARAPTPDGAHGRSVHGVVEELVADEMQRILGIEVNASTDFFDHGGNSLSATRLAARVSAVTGRSVSVRDVFTRRTAAGLAAVVAGAAERPALVAADDRSAPLAPAQRRLWLQHKLDPSSTAYHVPFVVELVGELSEEALRDALGDVLRRHAPLRTVLTENADGEPRPRLVEVDRAAVLGTRDVRDRDESQQLIDDFVSEPFDLATDVPIRFALHRIGDRCHELVVVAHHIALDGLSFAPLIADLTAAYTARRAGGTPPWAPLPVDYADYARWQHELLDSGIRDSDLAFWEGVLEGAPAVPGVPLDRSRSAVRGRAERVTASLDSEVWTALGAVARGIDATPFMVLHSAVAVLLSAITGTPDTLVGTAESGRNDPLLDELVGMFVGTVALRAHVHGDATFPDLVDAVRASDIDAFVHATTPFDVVQERCGGVRLQAMLAYESFADPALVWPGLEVRGQAVPGTDARSDLEIAVRETAAGLEIGFVYDSSVLDRRTVQGWASLLGNILDRVAVDPYRRIADLVTGGTPDVGPVAPRTPVTLSEIANGATRVVDAEGPARNIAPAAEALARHLSARGVASGEFVGILLPRSVEAVTAVVAVARAGAAFVPIDPHQPAHRIATILADSGARFVIARADADLPDGVHRIDPDALVDANHAEHEPFPTPHPDSAAYAIYTSGSSGTPKGVVVTHRGLGPLTTTLRRAFAITERSRVLHAASPAFDASILEYLLALGSGATLVVVPDGVYGPDEIADIVRTQRVTHWFSTPAVPAQIDPDDLDDLRVLGLGGEAWAWDTAARWAPGRTLLNLYGPTESSIVATISRPLDGLSNPPIGVPVDGSTVAVLDAELRPVGVGAVGELYLAGPGLARGYLGRPGLTAERFVASVLGPGRMYRTGDLVRRRVDGQYEYVGRSDRQIQIRGFRVELGEVEAVLTAHPDVDTAIAVEHAGTVAAFVHGRGHLDVERLRGFAAARLPRHMVPGVVTVLDTVPLTVAGKIDRAALPAPAAPRPDAREFHTAGQRTVARLMSEVLGGDALGRDSDFFVYGGNSLLATQLVSRIGSETGVRIDVRDVFENPTVAGLAGILDGIDGSPVPWQPSDSDEPAPLSPAQQRMWVLARRHTSAADNIAFALEIEGELDTGVLRTAVSDVLERHEALRTVFREIDGRPVQVVESAASVPEVIEAPNGCADRLQELAARPIDITSTAPVRLALYRTGNTSHTLAVVAHHAVLDGLSVVPLYRDLTEAFEARRRGTEPGWSPVRMRYTDYARWQRELLGDSSEPGSRAHEDLAYWTERLETAPQVLELPSDRSRSGEYGSAAGTVTFTIPAELHAALEKVALEYDATPFMVVHAALVVLLARLSGSDDVSVGTPVSGRSGPGLHDLVGMLVGTVVLRATVDQTRSFVDLLGRIRRDDLDALAHAETPFDQVVARVAPRTSGAHHPLFQVMLAYENFVPAEVPVPGLDIRVHEIHSGQTRFDLEVTLRERDLRMGEAAGIDGVLTYSRDLFDHETVARWAAWLVRVLETVTDDPTVVVDAIDPVARGGVLGGRPEAVAESRSGVCAGVTSLGELFVQRAAEHPDAVAVVAGDERITYAELDARSRLLAGRLAEAGVATEDVVALVLPRSVDLIVAMIAVVRAGAAYLPLDSTQPRDRLDMLIDQVGAALILHDGGFGGDGPSLEIASPPGRPDLDRCGPLDVAVRDDQAAYVIYTSGSTGRPKGVTVSHANVLALLANTFAGFGFGPSDVWTMFHSPAFDFSVWEIWGPLGTGGSIVVVDHFVARSPRELRELLVRERVSVLNQTPTAFAQLVDVAGEPDDLALRLLIFGGEALDVHRVSPWLDRHPTVRAVNMFGITETTVHATWTDIAPAEPADRSVIGVPLPGLQVDLLDRSLRPVPPGVVGEMYVGGPQVARGYRGRPGLTAGRFVAAPDGRIRYRTGDLARLRNDGTYEYRGRSDDQLQVRGHRIEPGEIVRALRGTTGVVDAAVAVRGGRLVAYVVGAARAEHSLAHRTIIQALRRVLPDYMVPATVVTMEALPLNANGKVDAAALPDPVDATVPSVVTGGARSPLEAVVLDVWSDLLGAPDLGRDDDFFDVGGNSLLATQVAGRLTSTTGVEIGVRDVFDAATAADLARTIETRVARPVGSSELRASTTPLDAGPLSPAQRRLWFQHLLDPASDVYNLAFTLRFSGDLVIGALEEAVRDVLRRHRVLRTTYTTGPDGPLQRVGDGPAVDLTPVAVPSGGLDDFVRSLARKSFDLEASAPLRFRLYRTADTEHVLAIVVHHIVADGWSLDPLSTDLAEAYRARVEGRCPQWSPLPLDYLDHARWQNTHVDANLDDWVEILDGAPTESSLPPDRVRSETVNPEVGAVHVALHGEPAERVAATARRHRSTTFMTIHAALAAVLARHNDTDDIVIGTAVAGRGDPRLDSLVGMFASTLPLRTDVAAGQAFADLLEHVRERDIEAFARVDTPFERIVERVAPERYSARHPIFQVALAVRRPGRVRFTLPGLEVSAAPIESASTQFDLHVTVTEKPDGLDFEFAYRSDLYEAATIEAFAARLILFLDHVTADPGLPIGDVGLLTATERRGLVPASGADGSVAGLWQVLAAGAAEHPDRVAVAAGDRTVTYRQLVVRAESLARELVARGAGPGVRVACAVPRSLDSVTAVWAIARTGAAPVMIDPEHPAARIQLMLEACGVRTGVTTAEGVVSLPSRVEWVDVAASGTGVLGEPAIHPDDAAYVVFTSGTTGHPKAVVLTARGLGAFGDDLAEIFAADADSRVLHVAGPGFDMALLEMLLAGMSGARLVVAPGSAYGGPELTELIAAERVTHACLTPSVASSVAAGSFPNLATLMLGGERVTDDVSARWGEGRRLFIGYGPAEATAFATWAGPLAPSDRPLIGRPARGIDAVVLDRRLQPAPPGVTGELYLAGDRLAAGYDGDGARTAERFVAAPGGRRLYRTGDLVRWIETPAGAMLDFRGRSDDQVKIRGVRVEPAEVDAVLRSLPGVRSAVTVPREHGDGHALYSYVVPESCDPARLRAALVDRLPAPMIPTAILTTESIPLTANGKVDAGRLPKPVRERSGAPTNPTEALVAEAYSAALGTDVDRLDDFFVVGGDSLLATAVVSQLRARLGREVPLRLLFDEPTVAGLAAAIEGGRFAASDGGPVAGTRPERLPLSRAQQRMWTQRRTGGVERYRLGARVELRGPLVPDALHAALTDVVERHEILRTFYSHDAAGPYASIGTAGRTDPHDDAVPLRVTLRADGPRTHTLEVELDHLAADGASVAILVTDLVTAYEARLVGDAPRWAPLPVQYVDYALWERDTASRSRDTEFWTHALADFDPALLPSVTNPGTEPGPVGSIDFEIDADVTAHLAHLAASRGATEFMVLHAALAATVARLSGQTDVGIAAVVSGRRYPQLIPVVGPFVDTVVLRARVEPGMPFAGLLGQVRDFDVAALDRAAAPIEDVLRSTGLSTPQVALALQDFTIPALHVGDLSIEAHETEPTTADFDIRFTLWHNESGGLTGRLLHDVSRFARPDAELLARQFTAVVGAAAAAPGTTVGHLPLLTAPARVSEADCEPTTLASMLRATAAAFPDRHAVTDGENTLTYRELDERSDASARRMSDEEGIGPEDVVALPPTRSIERVVQLWAVAKTGAAFGAHDHRSTRGSKSLVDAASAVDTLAYVITTSGSTGTPKQVAVTHRGLAALAAEARRRYRVGPGDRVLHGYDPAFDAALLEMLLAHTSGATLVVAPPDVFAGAPLHDLLRRQQVTHFLSTPAVLATLDADGLDHLQVVASGGESLAPETVRAWRTGRRMLDAYGPTESTVVALLADIGDEILLGEPIPGTGVLVLDTALHPVPLGGVGEMYLTGDGLARGYLDAPGETAARFVASTHGTGRMYRTGDRVRVGFDGRLRFLGRVDRQLKIRGARVEPAMVESALLQDSAVRRAAVTAVDGALVAFVCGDRIDPEEVLRAVTRTLPPTSVPSRLHVLDRLPTTSNGKTDFRSLTELARELADTSSDRPLSGTESVVAAVVSDVLGHRVDVDAGFFAVGGHSLAAVEVAGRLAQSLGRDVAPRAVLEAPTLAALARTIDTGAASARSELVRTDTEPVPIAPAQRRLWLLHRAEPDSADYVMPIVVRFGESLDPRALAAAVRDVVDRHEALRTYYPDETRQAVASSGDVEVAIVHEPLSRNELDRWIGRMASRPFDLTSRPPLRAALLRAESAEWILVVVTHHIAVDGASVAPLLGDGARAYAARAGGVAPQWESLPLRYRDFAHWQVRLLGDLDDPDSVGGRQLAYWARALTGAPDGPLALPFDRPRPAVPTHVGGTVHAVVGPELHAALVDSARRQGVTVFMILHAALAALLARYGGRDDVTIGTVVSGRPDARLDSVVGMFVGTLALRTVVDRAESFGEFLRRVRDVDLGALAHADVPFDDVVARVAPHRNRAHHPLFQVLLAHSAAAPELPDLPGLDLADAGPGAPPAQFDLVWDTTERADGQGVDARVVYATDLFDAATVDGLAAAWVGLLAQAAADMSRAVGDLALPEHPPLTVDTAPPELGLAEILAETVQRYPDREALRCGDESWTYTELAAAAEDRSQELKARGVQAGDIVPVDAVRGARWVVEVWALSRLGAAWVPIDPSHPEQRRRNLLDGAASASGDGLAYLLFTSGSTGVPKGVAVTHGGLSTLVDVQRRELDVTPEAVVLQAATPTFDACVFELLAAHAHGATLVCAPASIYAGTDLQGLVEREGVTHVNLTPTVLATLDPAAFSRSLTVVSAGEVLSERTAAAWAGHRLYNGYGPTECTVGATLGPVAHRGPVTIGLPMAGKTVRILDPRLRPVPTGVVGELYVGGAGLARGYHGAPGATAGRFVADPFAPGARLFRTGDLARVRADGSVEYVGRSDDQVQINGVRVEPSEVDAALAAAPSIRTSATVPIRQSNGERTLVSYVVARAGADLDAAQVRADLARLLPRHLVPSAVVHVERIPTTPGGKVDRAALPDPYLGVLDQETTPPQGPVERAVAAAMADVLGRGSVPRDRNFFELGGTSLGIVRLAARLRDDHGYDVALRELLADPSVASIADRVVAGSVEADPLATVVALNDPVNPAEPPLFCVHPLSGLAWSYAGLAGSTGGRPLYGLQATGEDGMPDGIGGLAARYVDRVRAIQPQGPYHLLGWSLGGNIAHEMAVRLQDIGEDVASLTILDAMPATAVPNAGAPDTAPVTELPDGLDPGTAERVLRTGEALETMAYRHRPRVFDGDVTLFVATRESDGRPALGKLWEPFVRGTVAEQLVDCAHADMSSAAVLDRVGKFLEGATGGEP
>NZ_CP041647.1|WP_084869989.1|3378516_3380364_+|DUF4012-domain-containing-protein
MEQTKSEESSVETATEAPSRRRTNRRRTVQPAATQRKRRRRIVIGTASAAAVAVAWGGYVAYEATQIKLNLEEAAEFATQTKDALLAGNSEEAVRSADDAARYAGRAKDATDSVSWRIAAAIPGIGGPFDTTRQISDVVQGLASDVLRPAVEAGSALSPDQLLLDGARIDLTGLRDAAPVLAETAAAADELAVRASEIDSTFVSQIDGPRQELVGQTTDLSSLLGNVSTAAEIAPAMLGADGPRSYFIGFQTNAEARGTGGLLGGFGELHAVDGAVRVDELASNRELSLAGRQGIDLGPDFERQYGQSRPTTDFRNSNASSHFPYAAQIWRSLWAQESGTQVDGVIATDPVALSYVLKVVGPVVMPDGEKVTADNVVELTESTAYTRFGTDNNARKQYLQNIAGKVVERMTGKISQPQALLEALGRAASEGRLAVWSSQPDEQDVLADTPLGHIVPDDDAPYAGVVVNNLGGNKLDYYLQREIDYTADSCSGDTRATTVKVRLTNTLPPGDYTKYVAGMFDNPMGAPAGTNLTNLSLVATQGAKLGKVTVDGKPAFAFTGAERGHPVFDLQFPIPQGKTVEVVYQLTEPASAKAPVVPVQPLVDAPTVAIDVPLC

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Crispr_ID: NZ_CP041647_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP041647_2

3439878-3440065

Orphan

Consensus_repeat	Method
CGCGTTTTGCGCACTTATCGCGCG	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP041647_2

>merge|NZ_CP041647|2|3439878-3440065|CRISPRCasFinder
CGCGTTTTGCGCACTTATCGCGGGATCCGGGGCCCACCCCTCGCGTTTTGCGCACTTATCGCAGGATCCGGGGGCCGCCCCTCGCGTTTTGCGCACTTATCGCGCGGGGAGGGACCTCCGCGGCGCGCTTTGCGCACTTATCGCAGGATCCGGGGCCCCTTTCCCGCGCTTTGCGCACTTATCGCGCG

>NZ_CP041647|2|2|3439878-3440065|CRISPRCasFinder
CGCGTTTTGCGCACTTATCGCGGG	ATCCGGGGCCCACCCCT
CGCGTTTTGCGCACTTATCGCAGG	ATCCGGGGGCCGCCCCT
CGCGTTTTGCGCACTTATCGCGCG	GGGAGGGACCTCCGCGG
CGCGCTTTGCGCACTTATCGCAGG	ATCCGGGGCCCCTTTCC
CGCGCTTTGCGCACTTATCGCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP041647.1\|WP_084870269.1\|3433151_3437396_+\|DUF3367-domain-containing-protein	unknown	unknown	gnl\|CDD\|378735
NZ_CP041647.1\|WP_013417244.1\|3446237_3447686_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143457
NZ_CP041647.1\|WP_013417248.1\|3451600_3452455_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187589
NZ_CP041647.1\|WP_013417231.1\|3427038_3427356_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133394
NZ_CP041647.1\|WP_084870062.1\|3441296_3443060_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041647.1\|WP_084870070.1\|3447788_3448742_+\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP041647.1\|WP_084870064.1\|3442976_3444206_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP041647.1\|WP_084870054.1\|3429836_3431039_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|366376
NZ_CP041647.1\|WP_084870067.1\|3444362_3445118_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP041647.1\|WP_084870057.1\|3431671_3432811_+\|isochorismate-synthase	unknown	unknown	gnl\|CDD\|224091
NZ_CP041647.1\|WP_084870073.1\|3448785_3450804_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP041647.1\|WP_013417232.1\|3429149_3429752_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP041647.1\|WP_005517572.1\|3432850_3433024_+\|DUF2613-domain-containing-protein	unknown	unknown	gnl\|CDD\|378543
NZ_CP041647.1\|WP_064079300.1\|3445263_3446151_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP041647.1\|WP_005517582.1\|3428543_3428843_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP041647.1\|WP_005517586.1\|3427550_3427925_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041647.1\|WP_005517564.1\|3438672_3439809_+\|DUF3068-domain-containing-protein	unknown	unknown	gnl\|CDD\|371444
NZ_CP041647.1\|WP_143524903.1\|3431148_3431616_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP041647.1\|WP_041674447.1\|3450866_3451460_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041647.1\|WP_005517529.1\|3452611_3453190_-\|serine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|223975

Protein	Function_ID	Function_description	E-value
NZ_CP041647.1\|WP_084870269.1\|3433151_3437396_+\|DUF3367-domain-containing-protein	gnl\|CDD\|378735	pfam11847, DUF3367, Domain of unknown function (DUF3367). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.	0
NZ_CP041647.1\|WP_013417248.1\|3451600_3452455_-\|SDR-family-oxidoreductase	gnl\|CDD\|187589	cd05328, 3alpha_HSD_SDR_c, alpha hydroxysteroid dehydrogenase (3alpha_HSD), classical (c) SDRs. Bacterial 3-alpha_HSD, which catalyzes the NAD-dependent oxidoreduction of hydroxysteroids, is a dimeric member of the classical SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.24926e-51
NZ_CP041647.1\|WP_013417231.1\|3427038_3427356_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|133394	cd04766, HTH_HspR, Helix-Turn-Helix DNA binding domain of the HspR transcription regulator. Helix-turn-helix (HTH) transcription regulator HspR, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	3.03521e-35
NZ_CP041647.1\|WP_084870070.1\|3447788_3448742_+\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	7.47571e-24
NZ_CP041647.1\|WP_084870067.1\|3444362_3445118_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	6.05764e-17
NZ_CP041647.1\|WP_084870054.1\|3429836_3431039_-\|beta-glucosidase	gnl\|CDD\|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	4.73145e-76
NZ_CP041647.1\|WP_013417244.1\|3446237_3447686_+\|aldehyde-dehydrogenase	gnl\|CDD\|143457	cd07139, ALDH_AldA-Rv0768, Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like. The Mycobacterium tuberculosis NAD+-dependent, aldehyde dehydrogenase PDB structure, 3B4W, and the Mycobacterium tuberculosis H37Rv aldehyde dehydrogenase AldA (locus Rv0768) sequence, as well as the Rhodococcus rhodochrous ALDH involved in haloalkane catabolism, and other similar sequences, are included in this CD.	0
NZ_CP041647.1\|WP_084870057.1\|3431671_3432811_+\|isochorismate-synthase	gnl\|CDD\|224091	COG1169, MenF, Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	2.30588e-118
NZ_CP041647.1\|WP_084870064.1\|3442976_3444206_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.21294e-55
NZ_CP041647.1\|WP_084870073.1\|3448785_3450804_+\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	3.07193e-25
NZ_CP041647.1\|WP_013417232.1\|3429149_3429752_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.16159e-17
NZ_CP041647.1\|WP_005517572.1\|3432850_3433024_+\|DUF2613-domain-containing-protein	gnl\|CDD\|378543	pfam11021, DUF2613, Protein of unknown function (DUF2613). This is a family of putative small secreted proteins expressed by Actinobacteria. The function is not known.	2.8313e-14
NZ_CP041647.1\|WP_005517582.1\|3428543_3428843_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.80103e-23
NZ_CP041647.1\|WP_064079300.1\|3445263_3446151_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.05591e-50
NZ_CP041647.1\|WP_005517564.1\|3438672_3439809_+\|DUF3068-domain-containing-protein	gnl\|CDD\|371444	pfam11271, DUF3068, Protein of unknown function (DUF3068). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	4.39005e-118
NZ_CP041647.1\|WP_143524903.1\|3431148_3431616_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	3.82419e-20
NZ_CP041647.1\|WP_005517529.1\|3452611_3453190_-\|serine-O-acetyltransferase	gnl\|CDD\|223975	COG1045, CysE, Serine acetyltransferase [Amino acid transport and metabolism].	1.66242e-80

>NZ_CP041647.1|WP_005517564.1|3438672_3439809_+|DUF3068-domain-containing-protein
MAERSGPSRILACILVGLGTFLLAVAVLIPTYTVDKLKKTPLDLEVTTVATGNGDVLDSKALLAGKAEVNTNVPIVAQRYVITEQPSDADVISLQAGQTLIRTDKQGESGLLTATVDRLTADRVSSMPVEPPVGTIQTSSTEPAEEVSHTGLQYKWPFDAEKKSYPYFDLNSRTTQDINFVEETEINGMKVYHYNQVIEPVDLSKVVPSAPTNKLTLPAKTWGVPGDDQPVTMIRWYANERDVWVDPITGVVIKGQEKLYQYYARDKAKPEVTVLKATLPFDENTIEYQIGQAKDGQDKLSLFGRTLPIVAGILGVIALIAGIFLGLRGGRGNKGATAGGPANPPAGSAGNDWTTDKTEEFPTVNMDKGGFTEPPRQQ
>NZ_CP041647.1|WP_084870269.1|3433151_3437396_+|DUF3367-domain-containing-protein
MVLSLLQSPGLVVADTKYDLTENPIGFLTRAAHQWSSIAPLGQVQNQAYGYFFPHGLFFAAGEFLHVPPWITQRVWWALLIVAGFWGVIRVAEALGIGSRSSRIVAAVAFALSPRVLTTIGSISSESLPMMLAPWVLLPVVLATSSPGRLSGGPSYQKGARVLAAQSALAVALMGAVNAVATAAACLVAGLWWIAHRPNRRWWVFTAWWIPSLLLATLWWIVPLLLLGRVSPPFLDYIESSGVTTQWTSLTEVLRGTDSWTPFVSPERVAGTVLVTQPVAVVATGLIAAAGLAGLCMRRMPAKGRLTLILLVGIAGLGAGYIGELGSPIADQVRAFLDGTGAPLRNVHKLEPLVRLPLVLGLAHLLAKVPLPGSVPVRRWRSAFAHPEREPLVAVTTLILVALTLTTSLAWSGRLAPRGAYDEVPAYWHEAAQWLEDNAAGSGSGADAERALVVPGAPFGAQVWGLTRDEPLQALASTPWAVRDAVPLVPPGAIRALDSVQRIISDGRPSAGLADTLLGQGIRYVVVRNDLDPDTSRSTRPLLVHQTVDGSPGLEKVAEFGEEIVPDTVDDVVIDSDLRPGYPAVEIYRVTSPDGATPAAGPYAVDLDRVPVVQGGSESLLRLAENGTVTGPALLASDAARAGIDATSVTVTDTPTNRETDFGQVDNHSSALRGPDDERRTYNAVPDYPVPGAALVEGEWSGATLSVSSAASDATQLGGTAPGSGPAATVDGDPATAWLSNGLETARGQWLRLDFDTPITRGMLHLTTSPAAFGPPVKWIRVETPNGSTSVRVDEPGKPVDVSLPSGTTPWLRILATHTEDGSPGYQFGISEISVDDYSTGTALPVPIVHRTVLPATPAGAQVRGWDLGQELPGRAGCADGPDRVHCSGSLVLPPEEPGTFTRTLSVPESTSVTPQLTLRPRPGAALEGLVTDPAAVSATGAADGVELRGTAAAAVDGDVATSWTAPTDSAQRKGGLPTLTIRLPQPTLVTGLQLTPSPGSLPAAPSRVAVNLGNGPQTRDLDTEGAAPQTVPLDPHVTDTIVLSLVQWDDVLDRTALGFLQRQPAGLSEVAVLGDGGRPVPGTATATTDRTVTVGCDIGPTISVGGTVVRTSVTATARQLASGQPVTATVCDPAPVPLPTGRQDVVVAPGPAFTVDNLRLDAAPAPAAAPVSSPAVGRWTENLRELDVAASDADQLLVVPESTNIGWVATAPDGTELQPVVVGGWQQGWIVPAGTDGVVTLTFPSDRWYRAGIAFGLLLLIPLALLALVPRRRNREPEPEGSAAPPRPWHSVVAAALGVTAVATVVAGPVGTGVTLLVAATAFGLARWRGDAFASRFLVGTAGVSLVIASVLLSTGPWRAADGYVGHSFLIQLFALIGVVCVGVSALPLRRSPMWRRFSQRLTARRAGSSTSA
>NZ_CP041647.1|WP_005517572.1|3432850_3433024_+|DUF2613-domain-containing-protein
MAKFLVPGVASAVIGAVVGAGAVLGVTAAAQDNTLPDIDRSGNANSSILNQVEYGSR
>NZ_CP041647.1|WP_084870057.1|3431671_3432811_+|isochorismate-synthase
MDGFLLSRSDRTLRTAGTRDRYDTVAAAAAALADGRVELVVGALPFDPSAPTALTAPASAAWTDGPWRPDTVVPLPRVTIAGEVPSPAEHVARVRRLVDRLRGGEFDKVVAARAVRLTADAPIDPEALAARMIRRHETANGFAVDLTASGEAYRGHTLVGASPEILLGRRGDVVTCRPLAGSAPRRADPDADQAEGAELLASAKNLAEHAYVVEWIREVLAPLCAELDVPASPELTRTGELWHLASPIRGRLLDGSVSSLELARRLHPTPAVCGTPTDRALDAIRDVEGDRRFYGGAVGWCDGAGDGDWVVAIRCAEIDADGTSALAWAGGGIVAASDPDTELAETTTKLGTLLGALGVDAHAAAPAGDTLTRTSRTHE
>NZ_CP041647.1|WP_143524903.1|3431148_3431616_+|universal-stress-protein
MPADLMLIAYDGSDNAKRAIQHAGRFLAANRAVVVTAWEPMVRQAARMSGLSGVMQPEWVPDEQSEDVALIDARTTNDEGVDLALAAGLNAEGRCCESSTAIWAAIVKCADELDADIIVTGTRGTTGLRSLLQSSVADHVLRHSHRPVLIVPPGK
>NZ_CP041647.1|WP_084870054.1|3429836_3431039_-|beta-glucosidase
MSTTVGTMRIRHAFALVLCAGLAAGCSSGNGTDTTATSQPSTSESAASSTSTTSQAAAPGPFGSAVCGPGFLKSLTERQKLAQLLTVGVTGTADALDVVKSEGIGGIFIGSWTDESMLANGEAAQVAEASAVPLMVTIDEEGGRVSRVDQLFGPDPSAREVARTMTTDQAYEMALERGRKLRSVGITVNFAPDVDVSSQPDDSVIGDRSFSDDPEVVTRYADAYARGMRDAGILPVIKHFPGHGSASGDSHTGAVTTPPLDQLQNTDLVPFRNLVDTEVGVMLGHLSVPGLTTGGLPASLSPQAVDLLRKGTGYDAPPFEGVIFTDDLSGMKAITDRFDIADAVEQALKSGVTSALWLTTDDVPRVLDHLEDAVAKGRLPQSQVDESVLTVARAKGAVSC
>NZ_CP041647.1|WP_013417232.1|3429149_3429752_-|TetR/AcrR-family-transcriptional-regulator
MAGGTKRLPRAVREQQMLDAAIEVFSDNGFHDASMDAIAARANISKPMLYLYYGSKDELFAACIHREGVRFVEAISPAGDPNLPPREQLRAALAGFLGFVDANRRSWMVLYRQAIGQQTFASQVSSSRDRLIELTAKLLESSTKDPEPGTDFSIMAVALVGAGEAVADRVAGGEIDVDAAVDLLENLAWRGLAGTSKKKQ
>NZ_CP041647.1|WP_005517582.1|3428543_3428843_+|WhiB-family-transcriptional-regulator
MTGISPNLAPLADTWEWQQHGRCQGMDESIFFPPTGERGNARMMRERRAKAICATCPVMKKCLEHSLALPEPFGVWGGMGESERAIALRGRRVRHRPAA
>NZ_CP041647.1|WP_005517586.1|3427550_3427925_-|hypothetical-protein
MPRTREHADHYADALTALAAATHRPANVVNTGAGYAIRVDFEYNRFLLATNHEVDGLSDDHASVERWTVRFFQAVADGSAEELVSVEHEWLVDAFDRAIAELDRTGNRIEADMELGELSPPSEV
>NZ_CP041647.1|WP_013417231.1|3427038_3427356_-|helix-turn-helix-transcriptional-regulator
MKATMTQQSPPRSTRGVYGISVTSELTGIGPQTLRLYERRGLINPSRTGGGTRRYSEDDIYRLSRVSELVEAGVNLTGIRQILDLEATNAELAAENERLRTELGQ
>NZ_CP041647.1|WP_084870062.1|3441296_3443060_+|hypothetical-protein
MTPRHPSLARAVPSLYSLVLAVLILGPLLGPGYLLLRDAVSTPRSYVTDSALGLTDAAARAVPQDWLIAVLSSVVDGGIVVKAILVAALWLAGWGAARMVAVLLPGVGVGPQLVASTVMLWNPYVAERLLQGHWSLLTGYAALPWVVCAAVAIRRGRPGAWWSMALCLAAAGLTPTGAILAAVVAAALLVRTSGSWDYRKGARAACCLVAASAPWLAATALSGGGGTSDPAGVAAFAARAEPGLGTVGSLAGLGGVWNSAAVPGSRTSLWALAGTMLLLAVVVCGLPALWRRRRHPVIATLAVLAGLAVLLPALGATGWGLSVGEWAVVHVPGAGLLRDSQKWVALAAPLYALAAAAGVRSLSKRASLPGAVPVAAIAAVVLALPDLVWGVGGALKPVQYPPAWRQVAQHLELSKEAGDVAVLPAGMFRKFPYSGDAPVLDPAPRMLPRDVLQTGQLVVGQAATVGGEGARATRVEQLLLAGAGPQALVDEQVRWVLVERTTPGPLGDSQRTLDQLEPVFADDELALYRVPGGIPPDPREGRGEALAAHLLWAALLVGGGLGVLQARRRGRSGFGAGDQPRHVPSGR
>NZ_CP041647.1|WP_084870064.1|3442976_3444206_-|glycosyltransferase-family-4-protein
MREVLLLCWRDTGHPQGGGSERYLEEVGAGLARRGIKVTLRTAGYPGAPREETVDGIRIVRGGGRLTVYPRALGAIVAGRLGLGPLAGLRPDAVIDTQNGIPFFSRTVAGAPVTVLVHHCHREQWPVAGRLMGHVGWWIESWLSPRVHRESQYLTVSLPSADELTDLGVERERIAVVRNGADAIPAGVEPGDDATRTTHPSVCVLSRLVPHKQIEDALAAVAQLRRTIPELHLDVIGGGWWEHNLRERAHELGIGDAVTFHGHVPEDRKHELLARSWVHVMPSRKEGWGLAVIEAAQHGVPTVGYRSSKGLTDSIIDGVTGLLVGGDDVAGQVDAVPALASAVESLLLDADLRADLGRKARLRANEFSWEQTAAGVHAVLASSAAGRHVSGLISGAEAAPTPSPGLQDA
>NZ_CP041647.1|WP_084870067.1|3444362_3445118_+|class-I-SAM-dependent-methyltransferase
MTRYFARRATLKRSVGLLSDFRYEQTDPDLFYGALARDSVELIGDLYRGHTERDLTGTTVLDVGGGPGYFADAFARAGARYVPVEPDPSEMHAAGLSVGDSIRGSGLALPIRSDAVDVCFSSNVAEHVAQPWVMAEEMLRVTKPGGLMVLSYTLWWGPFGGHETGPWHYLGGEYAARRYERKLGKEPKNRFGVSLFDIGAKDGLRWAKAQTGGDVLAAFPRYHPRWAWWMVKIPVLRELLVSNLVLVIRKR
>NZ_CP041647.1|WP_064079300.1|3445263_3446151_+|ROK-family-protein
MTALALDVGGTKMAAALVGADGRPLDTRTVPTPESGVWDACAALLRKVAGGTEVRGVGIASAGPVDLASGTVAPVNIGEWRDGFPIVDAVGALFPSATVRLALDGAAAALAEHRQGAGRGVPDLLGVVVSTGVGGGLIRGGRIESGRTGNAGHIGHMVVAGGEELCGCGAAGCLETVASGSAAMRWARAHGWTGATGADLAVDAELGEPTAAAALERAGVALGRAFASAAALLDVDLVVVGGGFAQSGPALWRPMTATAAAHAQLSFVRELRLVPAELGVLGTLTGAGLIAIDAV
>NZ_CP041647.1|WP_013417244.1|3446237_3447686_+|aldehyde-dehydrogenase
MTDYDKLFIGGRWVAPATDQRLEVFSPATEERVGSVPVAAPADIDAAVAAARAAFESGAWAETTPAQRGEILAKAAKLIEERSAELISTISDEMGAPASGVETMQKIMSLATLNYYANLANEFAWEETRNGAFGQTKVYREPVGVVGAVVAWNVPLFLAVNKLAPALLAGCTVVLKPAPETPLNANMLADIFTEAGLPEGVLSVVPGGAETGEYLVSHPDIDKVTFTGSTAVGRKIGAIAAEQLKRCSLELGGKSAAILLEDMDVAATMPMLVMSGLMNTGQACVGQTRILAPRSRYDEIIEAMVQFAGFMPVGMPDDPGAQLGPIITEKQRDKVLGYIEKGKAEGARVVLGGGVPAGLEKGWFVEPTIFADVDNSMTIAREEIFGPVLAVIPYDTVDEAVKIANDSDYGLAGSVYTTDIEKGLEVAKQIRTGTYAINWYAFDPGSPFGGYKNSGIGRESGPEGLEAYCELKSVLMPPGYTG
>NZ_CP041647.1|WP_084870070.1|3447788_3448742_+|cation-diffusion-facilitator-family-transporter
MATSPERTGGGESTLTVVVAFAANALIALAKSVAAVITGSASMVAEATHSWADTGNEVLLLVADRRARKAPDHAHPLGFGREAYIWSLFAALGLFAVGAGVSITHGIQELAHPELASDFGVAYAVLGIAFVLEAISFRQAFKQLRGEAHDAHRDVLEHALLTSDPTVRAVFAEDAAALIGLVIAFAGVLAHQLTGSPIPDAIGSIAVGVLLGVIALVLLDRNRRFLVGEPGTPELRTQAIRKLLTYDEVERVTYLRMEFLGPHQVYLVASVDLVGDYAESRIAHTLRALEDRITSETSAVRRAVLTLSTAEEPDLTV
>NZ_CP041647.1|WP_084870073.1|3448785_3450804_+|APC-family-permease
MAETDGAAVDPPDSATSRDAETSGRLEPVLPERLGYRIKCRLLGPPLTSARLHQERLSKTTALGVLSPDCISSSAYGPEQVLIELLPFAALAAFTLLLPITGVILVILLLLTLSYRQVVMLYTHAGGSYVVARDNFGPRTAQIAAVALLIDYVVTVAVQSAAGTVAVVSAVPALGPYSLEITIGAVLLLAYGNLRGLKEAGRAFAFPMYFFAASIGAVIVIGVIQALTGNLDRIDPTALDGTVDIAHGDGLVMGATVLVILRAFANGGTSLTGLEAISNGVSAFQKPEGVNARRALVIMASILAFLVSGVSLLAYLTHATPYAAGYPSVISQEARIVFGSGALGDVLFIVVQTATALILFTGANTSFNGFPFLASFVADDAFLPRQLRRRGHRLVFSNAIITLTAIAIVLLIATDAKVNSLVPFYAIGVFTGFTMAGLGMARHYQREKGRNWRRNMTLNLAAGITSAIVVGIFAIAKFTEGAWVVVIVFPTLVYVLIRLNREYREEAAELRELGDAEADAEAVYSHHIVIVMVDAFDLATIEALRYGRSLRPSELRAVHFVLDDAHAAHLKREWEASDLEVPLELIECPDRRLGHATLEMIARAGAPRTEISILLPRRIYRAPLGRVLHDRTADHIARIVSDLPHAVAIIVPYDTSSRRGVLRSPPPPPASS
>NZ_CP041647.1|WP_041674447.1|3450866_3451460_-|hypothetical-protein
MKKVAGGVVASAALVLGLAAGTGTAVAADRYDGPTLETAQGDFNGKNVELTLTNPKKAVGAFSETTCTSALLDGQQGLDAFIAFNAKDYGKLISIMTSPNLHLGPAASNNLISPGPNSNSKTVQVAEGVYIYLGTCGGWNSVLDPSNVGVSMQVLIVPDGIGSLSPALTFGSTALEAGVDLASLLPLLGSVGGGAGS
>NZ_CP041647.1|WP_013417248.1|3451600_3452455_-|SDR-family-oxidoreductase
MGVYAVTGSASGMGRAVVDKLTAAGHTVIGVDIQGADVVADLSTEAGRRQAIRDVLSRAGGTLDGAVLAAGVGPLPGAEKLPLIASVNYLGVVELLDGWRTALAASGSAKVVVFGSNSTTTTPAVPGRTVRALLARDVAKAARSVRLFGKGAAPMMYAGSKIAVSRWVRRNAVTRDWAGAGIRLNVLAPGAIMTPLLEKQLATPAEAKMIKRFPVPVGGFGDAGQLADWVVFMLSDAANFLCGSVVFVDGGSDAYFRPDAWPRTVPVTRLVPYVRKFLGFRGNR
>NZ_CP041647.1|WP_005517529.1|3452611_3453190_-|serine-O-acetyltransferase
MSVLRTIREDLQAARGQDPAARSNAENAVVYSGLHAIWSHRVAHRMWAKPALRGPARVLAQFTRFLTGVEIHPGATIGRRFFIDHGMGVVIGETTEIGDDVMIYHGVTLGGRSLAKAKRHPTIGNRVTIGAGAKVLGPLLIGDDSAIGANAVVTRDVPSDHIATGIPASVRPRKQHEQLVDPTSYIDPAMYI

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP041647_1	1.1\|3348542\|32\|NZ_CP041647\|CRISPRCasFinder	3348542-3348573	32	NZ_CP042915	Rhodococcus qingshengii strain RL1 plasmid unnamed2	27805-27836	8	0.75
NZ_CP041647_1	1.1\|3348542\|32\|NZ_CP041647\|CRISPRCasFinder	3348542-3348573	32	NZ_CP016313	Thermus brockianus strain GE-1 plasmid pTB1, complete sequence	188621-188652	8	0.75
NZ_CP041647_1	1.1\|3348542\|32\|NZ_CP041647\|CRISPRCasFinder	3348542-3348573	32	NZ_CP011481	Hoeflea sp. IMCC20628 plasmid, complete sequence	38504-38535	8	0.75

1. spacer 1.1|3348542|32|NZ_CP041647|CRISPRCasFinder matches to NZ_CP042915 (Rhodococcus qingshengii strain RL1 plasmid unnamed2) position: , mismatch: 8, identity: 0.75

ctcgccaaggctcccggcgcgaaggcaccggg	CRISPR spacer
gccgccaaggcacccggcgcgaaggctgcacc	Protospacer
 .********* **************  *.

2. spacer 1.1|3348542|32|NZ_CP041647|CRISPRCasFinder matches to NZ_CP016313 (Thermus brockianus strain GE-1 plasmid pTB1, complete sequence) position: , mismatch: 8, identity: 0.75

ctcgccaaggctcccggcgcgaaggcaccggg	CRISPR spacer
gtcgccaagactcccggtgcgaaggtgatcgg	Protospacer
 ********.*******.*******.. . **

3. spacer 1.1|3348542|32|NZ_CP041647|CRISPRCasFinder matches to NZ_CP011481 (Hoeflea sp. IMCC20628 plasmid, complete sequence) position: , mismatch: 8, identity: 0.75

ctcgccaaggctcccggcgcgaagg--caccggg	CRISPR spacer
aacgccaaggctcttggcgcgaagggtggccg--	Protospacer
  ***********..**********   .***

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

4076957 : 4084358

Planktothrix_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013417691.1\|4076957_4077683_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.8e-33	38.6
WP_005516643.1\|4077713_4078307_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_064076442.1\|4078513_4079503_+	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	5.2e-76	52.4
WP_013417694.1\|4079555_4079879_+	thioredoxin	A0A1J0GW78	Streptomyces_phage	4.2e-27	56.3
WP_005516639.1\|4080021_4081224_+	N-acetylmuramoyl-L-alanine amidase	U5PWQ2	Bacillus_phage	1.2e-05	27.2
WP_022598717.1\|4081273_4081963_-	hypothetical protein	NA	NA	NA	NA
WP_084870774.1\|4082197_4083349_-	ParB/RepB/Spo0J family partition protein	S5VTK0	Leptospira_phage	2.9e-09	30.7
WP_013417697.1\|4083350_4084358_-	ParA family protein	Q8JL10	Natrialba_phage	1.2e-24	32.4

DBSCAN-SWA_2

5088371 : 5104741

Rhodococcus_phage(55.56%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_143524932.1\|5088371_5088857_+	single-stranded DNA-binding protein	A0A2H4JEL4	uncultured_Caudovirales_phage	4.5e-57	71.3
WP_084969249.1\|5088865_5089396_+	hypothetical protein	NA	NA	NA	NA
WP_084980961.1\|5089392_5089656_+	hypothetical protein	NA	NA	NA	NA
WP_143524933.1\|5089652_5089964_+	hypothetical protein	NA	NA	NA	NA
WP_143524934.1\|5089960_5090725_+	hypothetical protein	A0A0K0NKV0	Gordonia_phage	1.5e-33	37.6
WP_143524935.1\|5091062_5091263_+	hypothetical protein	NA	NA	NA	NA
WP_143524936.1\|5091259_5091706_+	hypothetical protein	NA	NA	NA	NA
WP_143524937.1\|5091702_5092191_+	hypothetical protein	A0A159B6G0	Gordonia_phage	4.6e-33	54.9
WP_143524938.1\|5092187_5092418_+	hypothetical protein	A0A142KCZ0	Gordonia_phage	5.2e-11	48.8
WP_143524939.1\|5092587_5093256_+	hypothetical protein	NA	NA	NA	NA
WP_143524940.1\|5093252_5093693_+	hypothetical protein	NA	NA	NA	NA
WP_084969258.1\|5094153_5094345_+	hypothetical protein	NA	NA	NA	NA
WP_084956543.1\|5094370_5094736_+	hypothetical protein	G9FH25	Rhodococcus_phage	9.0e-42	79.4
WP_143524941.1\|5094876_5095233_+	hypothetical protein	G9FH26	Rhodococcus_phage	5.5e-36	73.0
WP_084956545.1\|5096718_5097984_+	DUF935 family protein	A0A142K8P5	Gordonia_phage	3.3e-115	54.2
WP_143524942.1\|5097980_5099126_+	hypothetical protein	A0A142KCI1	Gordonia_phage	3.4e-63	40.9
WP_143524943.1\|5099128_5099539_+	hypothetical protein	A0A142KCI2	Gordonia_phage	3.1e-30	61.5
WP_064077842.1\|5099552_5100476_+	hypothetical protein	A0A0U4KJL6	Gordonia_phage	1.2e-101	60.1
WP_064077844.1\|5100929_5101292_+	hypothetical protein	G9FH33	Rhodococcus_phage	6.2e-27	52.9
WP_143524944.1\|5101284_5101617_+	hypothetical protein	G9FH34	Rhodococcus_phage	2.1e-45	82.7
WP_064077846.1\|5101609_5101939_+	hypothetical protein	G9FH35	Rhodococcus_phage	3.2e-30	67.9
WP_064077847.1\|5101940_5102354_+	hypothetical protein	G9FH36	Rhodococcus_phage	4.6e-58	77.5
WP_084956557.1\|5102421_5103108_+	hypothetical protein	G9FH37	Rhodococcus_phage	3.9e-94	74.3
WP_064077849.1\|5103213_5103549_+	hypothetical protein	G9FH40	Rhodococcus_phage	2.4e-09	63.8
WP_087586966.1\|5103545_5103929_+	hypothetical protein	G9FH41	Rhodococcus_phage	9.5e-34	60.7
WP_064077850.1\|5103931_5104741_+	hypothetical protein	G9FH42	Rhodococcus_phage	5.2e-82	53.9

DBSCAN-SWA_3

5110867 : 5120238

Rhodococcus_phage(62.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_143524946.1\|5110867_5112442_+	hypothetical protein	G9FH45	Rhodococcus_phage	5.6e-290	90.1
WP_143524960.1\|5112886_5113966_+	hypothetical protein	A0A160DH52	Gordonia_phage	8.5e-80	46.0
WP_143524947.1\|5114651_5115131_+	hypothetical protein	NA	NA	NA	NA
WP_143524948.1\|5115117_5115849_+	hypothetical protein	G9FGX0	Rhodococcus_phage	3.0e-137	92.6
WP_143524949.1\|5115841_5117524_+	hypothetical protein	G9FGX1	Rhodococcus_phage	1.3e-103	79.2
WP_143524950.1\|5117523_5118408_+	hypothetical protein	G9FGX2	Rhodococcus_phage	7.6e-127	79.9
WP_143524956.1\|5118480_5118723_-	hypothetical protein	NA	NA	NA	NA
WP_143524951.1\|5118731_5119601_-	hypothetical protein	A0A1B0VBT5	Salmonella_phage	1.7e-14	31.1
WP_143524817.1\|5119756_5120035_-	hypothetical protein	G9FGX3	Rhodococcus_phage	1.3e-13	67.1
WP_143524818.1\|5120031_5120238_-	transcriptional regulator	A0A1U9WS04	Gordonia_phage	7.1e-20	68.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP041647

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection