CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP041626	Dolosigranulum pigrum strain 83VPs-KB5 chromosome, complete genome	1 crisprs	RT,cas3,cas9,cas1,cas2,csn2,DinG,DEDDh,csa3	2	5	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP041626_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP041626_1

802439-803201

TypeII

II-A,II-B

Consensus_repeat	Method
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	PILER-CR
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CRISPRCasFinder
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CRT

11 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_CP041626_1

>merge|NZ_CP041626|1|802439-803201|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACCGTTGAAGAGTTGGAGGTGGAAGAAGATGAGTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACTGGTATTCTAGCAAGTCATCAAGGAAATAAGTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACCGGCCAGAGATTAAAGAGGATTACCTCAGAGTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACCTTTTGATGAATTTAATGACCATATGGCTAGTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACTGCATCATGTCGAAGATGAACAGATTAGGGGTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACGAGCGCATTTGAAGTTGCTCAATCCCAAGAGTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACTACCAAAGGGAACAGTATGTGCGACTGCTGGTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACTGAGTTATTAACCAATAGACTGGATCACATGTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACAAAGTGTATCGGCTGTTTTCTAAGTTAGTTGTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACTCTTCCCGACAAACGATGCGAATAAGGCGGAGTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAACTTGTGCAGAACAGAGGGCTTCCCGGAACAAGTTTTAGAGCTGTGTTGTTTTGAATGACTCTAAATT

>NZ_CP041626|1|1|802439-803201|PILER-CR
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CGTTGAAGAGTTGGAGGTGGAAGAAGATGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TGGTATTCTAGCAAGTCATCAAGGAAATAA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CGGCCAGAGATTAAAGAGGATTACCTCAGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CTTTTGATGAATTTAATGACCATATGGCTA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TGCATCATGTCGAAGATGAACAGATTAGGG
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	GAGCGCATTTGAAGTTGCTCAATCCCAAGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TACCAAAGGGAACAGTATGTGCGACTGCTG
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TGAGTTATTAACCAATAGACTGGATCACAT
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	AAAGTGTATCGGCTGTTTTCTAAGTTAGTT
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TCTTCCCGACAAACGATGCGAATAAGGCGGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TTGTGCAGAACAGAGGGCTTCCCGGAACAA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCTAAATT

>NZ_CP041626|1|1|802439-803201|CRISPRCasFinder
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CGTTGAAGAGTTGGAGGTGGAAGAAGATGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TGGTATTCTAGCAAGTCATCAAGGAAATAA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CGGCCAGAGATTAAAGAGGATTACCTCAGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CTTTTGATGAATTTAATGACCATATGGCTA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TGCATCATGTCGAAGATGAACAGATTAGGG
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	GAGCGCATTTGAAGTTGCTCAATCCCAAGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TACCAAAGGGAACAGTATGTGCGACTGCTG
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TGAGTTATTAACCAATAGACTGGATCACAT
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	AAAGTGTATCGGCTGTTTTCTAAGTTAGTT
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TCTTCCCGACAAACGATGCGAATAAGGCGGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TTGTGCAGAACAGAGGGCTTCCCGGAACAA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCTAAATT

>NZ_CP041626|1|1|802439-803201|CRT
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CGTTGAAGAGTTGGAGGTGGAAGAAGATGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TGGTATTCTAGCAAGTCATCAAGGAAATAA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CGGCCAGAGATTAAAGAGGATTACCTCAGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	CTTTTGATGAATTTAATGACCATATGGCTA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TGCATCATGTCGAAGATGAACAGATTAGGG
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	GAGCGCATTTGAAGTTGCTCAATCCCAAGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TACCAAAGGGAACAGTATGTGCGACTGCTG
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TGAGTTATTAACCAATAGACTGGATCACAT
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	AAAGTGTATCGGCTGTTTTCTAAGTTAGTT
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TCTTCCCGACAAACGATGCGAATAAGGCGGA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCCAAAAC	TTGTGCAGAACAGAGGGCTTCCCGGAACAA
GTTTTAGAGCTGTGTTGTTTTGAATGACTCTAAATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP041626.1\|WP_143333310.1\|812756_813056_+\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
NZ_CP041626.1\|WP_143333306.1\|801633_802311_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd09758_csn2_CAS-II-A	gnl\|CDD\|213408
NZ_CP041626.1\|WP_112787495.1\|806981_807944_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|182727
NZ_CP041626.1\|WP_143333308.1\|808126_810955_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP041626.1\|WP_004636536.1\|791491_792175_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP041626.1\|WP_143333309.1\|811105_812773_+\|daptomycin-sensing-surface-protein-LiaX	unknown	unknown	gnl\|CDD\|372574
NZ_CP041626.1\|WP_143333303.1\|792149_793193_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|340424
NZ_CP041626.1\|WP_112787496.1\|806325_806799_-\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|238207
NZ_CP041626.1\|WP_112787580.1\|804387_806187_+\|oligoendopeptidase-F	unknown	unknown	gnl\|CDD\|341072
NZ_CP041626.1\|WP_040376839.1\|801305_801653_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_CP041626.1\|WP_004636521.1\|813167_813350_+\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|224894
NZ_CP041626.1\|WP_143333302.1\|790288_791029_-\|cyclase-family-protein	unknown	unknown	gnl\|CDD\|224790
NZ_CP041626.1\|WP_077862206.1\|793279_794020_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP041626.1\|WP_111949368.1\|800439_801309_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NZ_CP041626.1\|WP_143333307.1\|803418_804372_+\|hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240632
NZ_CP041626.1\|WP_077862218.1\|813370_813673_+\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
NZ_CP041626.1\|WP_143333305.1\|796441_800440_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226044
NZ_CP041626.1\|WP_143333301.1\|789087_790245_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-methyltransferase	unknown	unknown	gnl\|CDD\|180482
NZ_CP041626.1\|WP_143333304.1\|794021_795917_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|376899
NZ_CP041626.1\|WP_004636519.1\|813777_814131_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377198

Protein	Function_ID	Function_description	E-value
NZ_CP041626.1\|WP_143333310.1\|812756_813056_+\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	8.75746e-24
NZ_CP041626.1\|WP_143333306.1\|801633_802311_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	1.00105e-107
NZ_CP041626.1\|WP_112787495.1\|806981_807944_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|182727	PRK10783, mltD, membrane-bound lytic murein transglycosylase D; Provisional.	1.48934e-14
NZ_CP041626.1\|WP_143333308.1\|808126_810955_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP041626.1\|WP_004636536.1\|791491_792175_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.60541e-55
NZ_CP041626.1\|WP_143333309.1\|811105_812773_+\|daptomycin-sensing-surface-protein-LiaX	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	3.3112e-16
NZ_CP041626.1\|WP_143333303.1\|792149_793193_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|340424	cd16948, HATPase_BceS-YxdK-YvcQ-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ. This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.	4.97915e-41
NZ_CP041626.1\|WP_112787496.1\|806325_806799_-\|glutathione-peroxidase	gnl\|CDD\|238207	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per subunit, which is involved in catalysis. Different isoenzymes are known in mammals,which are involved in protection against reactive oxygen species, redox regulation of many metabolic processes, peroxinitrite scavenging, and modulation of inflammatory processes.	2.92202e-74
NZ_CP041626.1\|WP_112787580.1\|804387_806187_+\|oligoendopeptidase-F	gnl\|CDD\|341072	cd09609, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and is similar to oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid.	0
NZ_CP041626.1\|WP_040376839.1\|801305_801653_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.83946e-42
NZ_CP041626.1\|WP_004636521.1\|813167_813350_+\|PspC-domain-containing-protein	gnl\|CDD\|224894	COG1983, PspC, Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms].	1.20677e-14
NZ_CP041626.1\|WP_143333302.1\|790288_791029_-\|cyclase-family-protein	gnl\|CDD\|224790	COG1878, COG1878, Kynurenine formamidase [Amino acid transport and metabolism].	2.902e-58
NZ_CP041626.1\|WP_077862206.1\|793279_794020_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	2.67284e-101
NZ_CP041626.1\|WP_111949368.1\|800439_801309_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.10434e-113
NZ_CP041626.1\|WP_143333307.1\|803418_804372_+\|hydroxyacid-dehydrogenase	gnl\|CDD\|240632	cd12155, PGDH_1, Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family. Phosphoglycerate Dehydrogenase (PGDH) catalyzes the NAD-dependent conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first step in serine biosynthesis. Over-expression of PGDH has been implicated as supporting proliferation of certain breast cancers, while PGDH deficiency is linked to defects in mammalian central nervous system development. PGDH is a member of the 2-hydroxyacid dehydrogenase family, enzymes that catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	2.6058e-113
NZ_CP041626.1\|WP_077862218.1\|813370_813673_+\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	8.69558e-20
NZ_CP041626.1\|WP_143333305.1\|796441_800440_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|226044	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms].	0
NZ_CP041626.1\|WP_143333301.1\|789087_790245_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-methyltransferase	gnl\|CDD\|180482	PRK06233, PRK06233, vitamin B12 independent methionine synthase.	1.74274e-82
NZ_CP041626.1\|WP_143333304.1\|794021_795917_+\|FtsX-like-permease-family-protein	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	6.89668e-09
NZ_CP041626.1\|WP_004636519.1\|813777_814131_+\|phage-holin-family-protein	gnl\|CDD\|377198	pfam04020, Phage_holin_4_2, Mycobacterial 4 TMS phage holin, superfamily IV. These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.	3.30899e-23

>NZ_CP041626.1|WP_143333306.1|801633_802311_+|type-II-A-CRISPR-associated-protein-Csn2
MPMKLNSHLLEAPIEINGCTQFVVEDVAAYAATVLACHRYGEESDLKLFNNDCKSLKSSEVITITDIFNYNINTSAILKQIHSEIEDQLNEKSAVKTEIEQLTNQITELINAEVLNHELDLELDEITIQEVLIALGVKIEVDTDTLFEKVLEIFQVFKYLRNKKLLILVNVASYFTTEELNEMAQFVSLLQMNVLMIEPKPTDSEITQYILDSDFFLTIKHGKMK
>NZ_CP041626.1|WP_040376839.1|801305_801653_+|CRISPR-associated-endonuclease-Cas2
MSYRFMRMLVMFDMPTETANDRKAYRQFRKFLINEGFIMHQFSVYTKILLNNTAKNAMVKRLEANTPKNGHITALTVTEKQFSRMIYLSGTQDKRVAQSDQRLIFLGDDYADEIK
>NZ_CP041626.1|WP_111949368.1|800439_801309_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRTIVVNQHSKLNYKNNHLVYKTSTQTEMIHLSEVDILIAETTDINITTMLLKRLVDYRVLVIFCDDHRLPASMLQPFYGSHDSSLQLKQQIDWSIDKKEYTWTKIIEQKIMNQAEFLASIDYKKQSEKILKLVDSLEVLDPTNREGHAARMYFNTLYGNDFSRKHTDNDINAALNYGYTLILSIFAREIVKTGCLTQFGLKHANQFNQFNLASDIMEPFRVLVDRIVYQNRNRSFDGMKRQLFNLFHDTYPYGSQNMYLTNIASDYTKKIIKVLNGEITDVPEFRL
>NZ_CP041626.1|WP_143333305.1|796441_800440_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MQRNYTIGLDIGTNSVGWAVMKDDYTLIRKRMKVLGNTDIKKIKKNFWGVRLFDEGETAKETRLKRGTRRCYQRRRNRLIYLQDIFQQPMLAIDKNFFHRLDDSFFVPDDKSYDRHPIFGSLEEEVTYHNTYPTIYHLRKHLADNPEKADLRLVYTALAHIVKYRGHFLIEGELNTENTSISETFEQFLDTYNDIFKEQLVGDISKVEEILSSKQSRSRKHEQIMALFPNENKLGNFGRFMILIVGNISNFKPVFDLDDEYKLKLSDETYEEDLDTLLGMTDDVFLDVFMAAKNVYDAVEMSAIISTDTGNSKAVLSNQMINFYDEHKVDLTQLKQFFKTHLPDKYYECFSDSSKNGYAGYIDGKTNQEDFYKYIEKVIKTVKSDEKDYFLDKIDREVFLRKQRSFYNSVIPHQIHLQEMQAILDRQSQYYPFLAENRDKIESLVTFRIPYYVGPLTASDQSEFAWMERQSDEPIRPWNFDEIVNKERSAEKFIERMTNMDTYLLEEKVLPKRSLLYQTFEVYNELTKVRYTNEQGKTEKLNRQQKTEIIETLFKQKNRVREKDIANYLEQYGYVDGTEIKGLEDKFNASLSTYNDLVKIDGAKAYLDDPEYADMWEEIIKILTVFEDKAMRKKQLQTYSDTLSPEILKKLERKHYTGWGRFSKKLINGLRDEGSNKTILDYLKSDEGSSGPTNRNFMQLIRDNTLSFKKKIEDAQTIEDTTHIYDTVADLPGSPAIKKGIRQALKIVEEIIDIIGYEPENIVVEMARESQTTKKGKDLSKERLEKLTEAIKEFDGPTDIKVKDLKNENLRNDRLYLYYLQNGRDMYTNEPLDINNLSKYDIDHIIPQSFTTDNSIDNKVLVSRTKNQGNKSDGVPSINIVHKMKPFWRQLHKAGLISDRKLKNLTKTEHGGLTEADKAHFLNRQLVETRQITKHVANLLDSQYNTAEEQRINIVLLKSSMTSRFRREFEMYKVREINDYHHGHDAYLNAVVATTIMKVYPNLKPQFVYGQYKKTSMFKEEKATARKHFYSNITKFFKKEKVVNEETGEILWDTERHLSTIKRVLSWKQMNIVKKVEKQKGQLWKETIYPKGDSSKLIPVKEGMDPQKYGGLSQVSEAFAVVITHEKGKKKQLKSDLISIPIVDQKAYEQHPTAYLEEAGYNNPTVLHELFKYQLFELEDGSRRMIASAKEFQKGNQMVLPLELVELLYHANRYDKVKFPDSIEYVHDNLAKFDDLLEYVIDFSNKYINADKNVQKIQKIYKEHGTEDVELTVESFVNLMTFTAMGAPATFKFYGESITRSRYTSITEFRGSTLIFQSITGLYETRYKLEDN
>NZ_CP041626.1|WP_143333304.1|794021_795917_+|FtsX-like-permease-family-protein
MTLGKFSFKNIKEHLEQYMGYWLSCVTTVFIFFIFSMNQYHPELNQGPGAIATIMQGAQLIVLIFAIFFLSLSINAFLTDRKKDFGVLLMMGMSKRSLRQLILFENMLLGLTALGVGIGLGLIFGHLLILMMGYIIRVSEITYHFPAMSIVITVSLFSLIFLLLAVVQGRRITKQSIYDLMRVDTNEYEQVIYSKPLAYLGVISLVSGYLIANISLINRLFGGQIAWIQRMVHFTELHLVIGGLVTIGMFLLFSQFFKYFMDVLRRNKSFYFSGLNALWIAELKYRLSSNAVTMFVAALLLSSAFVTTIGTISLIATTEEEVSEEMPYDLMYYSDYPNNKLEAELTIVQQEHDRQNLPYTERLIRLYYDEASEVRFISQTDYNDAVSTNEQIQLSIGEVALIEAGEEELNEQLRIAGETLTVTDTAHQLFDSYRYNKLFVLNDASSLLTEQFLEGQAYLFHYEAGYDQTAARQISASLRDKLGPTLPDGGTYLLASKIERIDIEIYSYQLLTYVGSLLSFIFMVASGSLIYFRLLKNISRSKQIYTNLFKLGLDKKALWTIQLKQFRFLFFAPVVMAFINCFFAINMLQELLHTSIWTLVLMIGVALLTFQFAFYYFAKEKLKEKIMLQIG
>NZ_CP041626.1|WP_077862206.1|793279_794020_+|ABC-transporter-ATP-binding-protein
MSILQLENVSVIYGDNLQTKGLNNLSLETKAGEFVAIMGPSGSGKSTLLNTVAGILPATSGRIQVAGRAIDGLSDEEAAQFRREELGFVFQEFNLVETLNVKENIVLPLMFQHQSVDVMEERMTKLAEALGISAILDKRVTEISGGQRQRVAIARAVIHQPALLLADEPTGNLDSKNSKEVMSVFKELNEQLNLSIFLVTHDAMTATYSDRIIFIKDGRLYNEIYRGDDELGYKQSIINVLEMMGE
>NZ_CP041626.1|WP_143333303.1|792149_793193_+|HAMP-domain-containing-histidine-kinase
MVTAWNVCRGVRLNLVKEFVMLRIFLKQHRSYIIVYVLNFILISYLVFVTGAAIDDRLISYAGLLSFVLLVLFLVWRFWQMRPLYEELSKSVMQLEDMKVNLPKKDAVTAQFVQYMDQQYKVGREALLEAEANNEQWRLLIINWVHHMRSPINGLRLALENKREGAYYELLLECDRLDQQLDTILNLARVSSIASDLVIEELDLNDVLKTAINNHKRQFIYKQITPAFKSITDAYVYSDRKWLTFIIEQLLRNALKFSRMNSVMTCTVTRTDGAISLIITDQGVGIPASDLPRVFELYFTGYNGRHNKSSTGIGLYLVKQVATELNIKVGIESEEQVGTQITLTFPQ
>NZ_CP041626.1|WP_004636536.1|791491_792175_+|response-regulator-transcription-factor
MAKLVAIVEDDVTLASSMRQGLQKYGYDVWVAEEFQQIAQDIVAVDPDLVLLDINLPNFDGYHWCREIRKQSRVPIIIVSSRDSKMDQILGIEFGADDYILKPFDMEILLSKIQGLMRRVYGELAMKDLELEVNQVMLNKEALQLHYGELIADLTVVECRVFQTLMERFPEAARREELMIAVWDDDTLIEENTLNVNMKRCRDVLKTCQLPLQIKTIRSYGYRLECL
>NZ_CP041626.1|WP_143333302.1|790288_791029_-|cyclase-family-protein
MTTLYKLLEQLKSHNWIDLTHPVHTDIPRFSAFNPIIVESIATIDTDGFLGQQVTIGTQYGTHIDAPNHFAKGRRELTELTLKERTLPLYVIHKVAAAKENPDYELTIQDIKAFEAEHGQIQPDSFVAFATGWSDRFDSPEAFYNRDEDGVEHTPGWSVEALQFLHEERNVTAIGHETLNTDSGTAIAKHQALPAELYWLEQDKYQVEVIKGLADLPATGALIHIAAPRIEGLGGFNTEVFAILPN
>NZ_CP041626.1|WP_143333301.1|789087_790245_-|5-methyltetrahydropteroyltriglutamate---homocysteine-methyltransferase
MTYTSNRFLTVGSLLRPEDLLNYKEQIRQAEDITYPFYNDFDGYKETETAAVKSVIEKQVEVDLPELTDGEYSKALWHTDFVWGLNGARRYIAEQGYFFRDKDSKESTYETRRDIGVDFVDAIDGKNHPFLDHFRRLAELSPDDATLKQCIPSPSHIYGENLVFGKLSGTYYEGKEEQFRQDLAQAYKDFLDEFKQVGGKIIQFDDCLWELFSDDDHPFIDDKEKFEALAQEFIDLNNEVIAFAHDLGLKVYTHNCRGNYDSRNMSDGTYESISHLFLKQLNYDRFYLEWDDERAGSLNALEAFSDRPDTEVVLGLLSSKTDHLDDEERVQSALKEATQYVAKDKLYLSHQCGFASCDNGNQLSHDQQWAKIKQGQKIALDFWGE
>NZ_CP041626.1|WP_143333307.1|803418_804372_+|hydroxyacid-dehydrogenase
MAVSKELLVLIDYEVDVLETFREMASEYQLVSEFEEADFSKVEIVLGWDERLVDVLESGQHQLKWIQLSTAGVDKLPLDLLAQEGVRLTSASGMHTHSLAESIFGMLLARTRGILQSVEANQQKQWVQEEIEPVVLFDKSVTIIGAGKIGTEVAHMAKAFGMQTTGVNRSGGQIDGFDKVYTNDNLAEAVADADVVINILPLTPETTGLFNLSLFKQFKPGAMFVNVGRGESVVTADLLTALDQELLSFAALDVFEEEPLPAESPVYTHSKILATPHIAGFMDDYLGTLRPIIEENLQAFIDREELPVSEVNLDRKY
>NZ_CP041626.1|WP_112787580.1|804387_806187_+|oligoendopeptidase-F
MSEKLQERSQVSAALKWDLSAIFESERAFEETLEQLGGKAKEFKEQYAGRLTEAGIILESIQVYESIQSLTSRVYDYAFLPTSVDITDAKSQKRVQRVSNELAKLGAILSFYESELMEAEEATLDAVVALDECYEPFIREVKKGKAHKLPAVVEEALANLSPVLDSHAELFEQIRSADADFGTFEANGKQHDLSFVGYEEGYMYSEDGEIRRQSYDQFNQVLGQYQHTAATNYYNHVMKEKTLATMRGYDSVIDYLLDSQDVDRAMYDRQIDLIMSDFAPVMRKYITHVKEEQGLDKMTYADLKLDLDPDYTETLTIAESREVIAQAVEVLGDDYVDIMMRAYDENWIDFARNKGKRSGAFCSTPADTHPYIMLSYSGLLSDAYTLIHELGHAGHFHYVYQEQVLTAGRPSLYLIEAPSTFNELLLSDYLRKDADSPRKERSIIAKMISKTYFHNFVTHLLEADFQRKVYERIDAGQGFDANVLNELKRETLEAFWGDAVEIEPGAELTWMRQVHYFYGLYPYTYSAGLTIATQAFLKLKAGELEAENWLDFLKLGGRQLPKDAAKVAGVDVGSDQALKDTIAYLDESVDRMIELTTQL
>NZ_CP041626.1|WP_112787496.1|806325_806799_-|glutathione-peroxidase
MNLYDIKVKPIDQPAITLNNYKNQTILIVNTASNCGLKNQLEELETLYQDYKDCGFTVLGFPCNQFLGQEPLDGMEIQNFCATNFNVTFPLFEKVKVNGKHTHPLFATLKERTGLKLIKWNYNKFLISPNADVVKQFSPITSPLDLREEIKALLPAD
>NZ_CP041626.1|WP_112787495.1|806981_807944_+|LysM-peptidoglycan-binding-domain-containing-protein
MKKQINVKSLSTIALVALTSSIIGVSTVSASSGETGNINQPALYTVQEGDNLYRISQRYNMSIEELKQLNALGEAYMLHPGDQLKVERNQSNSDKKVYEVKAGDSPYKIAQKFGVTVADIYQWNHIDAGTMLYPGNTVVVSGGTKKTTDTAEKGIDRIHEVTNNKYNSDSYEVRVERKQADHTVIYSLADKTPEKLTVFKWFKYDTATDRVFESTDAAPNSWARLHDGEPVASIEQTGQEKALSEEGIRKVHDLTDYAYNTENYFITSEVIDEHTVKFDVSDDSAEKITPIKAFKYDAKTGKVYVQEIEDRAADKWHLIN
>NZ_CP041626.1|WP_143333308.1|808126_810955_+|excinuclease-ABC-subunit-UvrA
MGKDEIIIRGARSHNLKDIDVVIPRDKFVVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGQMDKPDVDSIDGLSPAISINQKTTNNNPRSTVGTVTEINDYLRLLYARIGVPICPNDGHEITSQSVEQMVDTIMELPERTKLQILSPVVKAKRGQHKRLLDKIKADGYVRVRVNGEIVDITEVPELDKNKQHDIDVVVDRIVVKDGIRSRLFDSLETALNRSDGYATIDVIDGETLQFSEHHACPYCDFTVPELEPRLFSFNAPFGSCPECEGIGTKLEVDYSLVVPDESLTLEEGAMAPWQPISSDYYPEMLKQACDQFDIDMTVPFKDLPKEDQELVLHGSGEREFKFSYTNNYGNVRDSVMPFEGVIENVSRRYYETSSDFTRRTMKEYMTELTCPNCHGKRLNEQALSVKVLGKDIGDVNELSIDKAKDFFGEMDLSDKDLAIAKPIRKEISDRLTFLKNVGLEYLTLSRKAGTLSGGEAQRIRLATQIGSNLSGILYILDEPSIGLHQRDNDRLIDSLRQMRNLGNTLIVVEHDEDTMRAADYLIDMGPGAGSEGGCVVAAGTPEEVSQSKDSITGDYLSGQRRIHVPEERRVEDQGAIAIRGAAENNLKEVDVDIPLGRLNVVTGVSGSGKSSLVNLVMKKVLAREVGRSKDKPGKHRSVTGYEGLDKIIDIDQSPIGRTPRSNPATYTKVFDDVRELFAQTNEAKKRGYKKGRFSFNVKGGRCEACKGDGTLQIEMHFLPDVYVPCEVCKGKRYNSETLEVEYKGKNIAEVLDMNARDAADFFENIPKLKRKLDTIIDVGLGYITLGQSATTLSGGEAQRMKLASELQKRQNGHNFYILDEPTTGLHTHDIAKLLEVLQRLVDVGNTVVVIEHNLDVIKVADYVVDLGPEGGVGGGTIIGAGTPEEIAKIPESYTGQYLKPLLTPSS
>NZ_CP041626.1|WP_143333309.1|811105_812773_+|daptomycin-sensing-surface-protein-LiaX
MMNERERILDLVKQGVLSTDEGLELLENLAKQENKRMEAKEFDKEITTETEWDSYDETADYQQELEELANEMTQYSAELDRLNASITQQKQKRQAVKAELDQLKARAESEYTQAIEKQQDRLADLREELTLVQAIDEVDNHDEVASLKEKIQAREEQLVDLKEDAYEATEQMIDLEEDLQDIDQELAELDEEKRELSDELNSLKMRKWSTKAKEVTSQFDFSPDEWKEDTEKALKKAGQTVGSASKDLGELIKTTIESARGLFDNFEWSEQVIKVPTLASDSFDKEWIIAENPTILDFKNANGNISFESTTDEQMRISANITIYGKYDEATVEEAFAVRHQYVVDEDKLTFHIPNKRIKADIIVALPKQTYDYLTVNVLNGNISLSHIDLKDLYMKSTNGDFKLNKIKATMIEIKGTHGDIYQKDVDIQDLIINTVNGDIQIRGDVISSALTTTNGDIRMTLFNPEATQLEAITVNGDVKVALPSTSDIDVEGKAAFGKVKSRLNDVEEDPNGKKNFRSFKRLKYGNPMTVQAKTTSGSIYFKDTDEKVGNSDES
>NZ_CP041626.1|WP_143333310.1|812756_813056_+|PspC-domain-containing-protein
MLMNRKLTKSPHKKIAGVAGGLAEYFGIDPSAVRLAWVIATVFSGGSAIPVYIILAILMPKSDNHHARRYRSRQKSKQFGNKRSAPRQARVDDDEFADF
>NZ_CP041626.1|WP_004636521.1|813167_813350_+|PspC-domain-containing-protein
MKKLTKSRDKWLCGIIGGLAEYFGWDRDMSRLLFILVVAFGAGSPLLLYVLLYFIMPEAD
>NZ_CP041626.1|WP_077862218.1|813370_813673_+|PspC-domain-containing-protein
MSSQKLYKSKNNSILFGVLGGLSEYFKVDPVLCRVLFVIAVVMLDTLSGLFILVYIVLAFVMPEKPVDYSDQPLDHSHYNQTPKQPIDVDEMDEDEWSNF
>NZ_CP041626.1|WP_004636519.1|813777_814131_+|phage-holin-family-protein
MKWLQTTLLNTVMFLALAGFFSGLVIDTWQTALMAALVFGILNAIIKPILVILSLPLTILTLGLFYFIVNGAVLYMTSYFVSGFYISSLGWATFLAIIISLVNSLFVAQTDIQYRRF

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Identity
NZ_CP041626_1	1.8\|802937\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802937-802966	30	NZ_CP041626.1	1959014-1959043	1.0
NZ_CP041626_1	1.8\|802937\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802937-802966	30	NZ_CP041626.1	2011732-2011761	1.0
NZ_CP041626_1	1.8\|802937\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802937-802966	30	NZ_CP041626.1	2064450-2064479	1.0
NZ_CP041626_1	1.9\|803003\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	803003-803032	30	NZ_CP041626.1	336465-336494	1.0

1. spacer 1.8|802937|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to position: 1959014-1959043, mismatch: 0, identity: 1.0

tgagttattaaccaatagactggatcacat	CRISPR spacer
tgagttattaaccaatagactggatcacat	Protospacer
******************************

2. spacer 1.8|802937|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to position: 2011732-2011761, mismatch: 0, identity: 1.0

tgagttattaaccaatagactggatcacat	CRISPR spacer
tgagttattaaccaatagactggatcacat	Protospacer
******************************

3. spacer 1.8|802937|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to position: 2064450-2064479, mismatch: 0, identity: 1.0

tgagttattaaccaatagactggatcacat	CRISPR spacer
tgagttattaaccaatagactggatcacat	Protospacer
******************************

4. spacer 1.9|803003|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to position: 336465-336494, mismatch: 0, identity: 1.0

aaagtgtatcggctgttttctaagttagtt	CRISPR spacer
aaagtgtatcggctgttttctaagttagtt	Protospacer
******************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP041626_1	1.4\|802673\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802673-802702	30	NZ_CP010312	Geoalkalibacter subterraneus strain Red1 plasmid pGSUB1, complete sequence	222502-222531	5	0.833
NZ_CP041626_1	1.4\|802673\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802673-802702	30	NZ_CP047806	Staphylococcus aureus strain UP_1654 plasmid unnamed, complete sequence	25448-25477	6	0.8
NZ_CP041626_1	1.5\|802739\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802739-802768	30	NC_023688	Aeromonas phage PX29, complete genome	48756-48785	6	0.8
NZ_CP041626_1	1.5\|802739\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802739-802768	30	MH791401	UNVERIFIED: Aeromonas phage AsFcp_2, complete genome	218914-218943	6	0.8
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NC_019290	Periwinkle little leaf phytoplasma plasmid pPLLHn-1, complete sequence	558-587	7	0.767
NZ_CP041626_1	1.5\|802739\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802739-802768	30	CP018841	Staphylococcus phage HOB 14.1.R1, complete genome	3414-3443	7	0.767
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NC_018516	Bacillus thuringiensis HD-789 plasmid pBTHD789-1, complete sequence	203466-203495	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP053970	Bacillus thuringiensis strain FDAARGOS_796 plasmid unnamed2, complete sequence	226982-227011	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP053979	Bacillus thuringiensis strain FDAARGOS_795 plasmid unnamed3, complete sequence	135194-135223	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP013277	Bacillus thuringiensis serovar israelensis strain AM65-52 plasmid pAM65-52-2-350K, complete sequence	3916-3945	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP039723	Bacillus thuringiensis strain BT-59 plasmid p2, complete sequence	120917-120946	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP009348	Bacillus thuringiensis HD1002 plasmid 2, complete sequence	3916-3945	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP009334	Bacillus thuringiensis strain HD1011 plasmid 2, complete sequence	137663-137692	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP045024	Bacillus thuringiensis strain JW-1 plasmid p2, complete sequence	3916-3945	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP004876	Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB299, complete sequence	13797-13826	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NC_017203	Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281, complete sequence	49565-49594	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NC_020384	Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-285, complete sequence	53788-53817	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP011350	Bacillus thuringiensis strain YC-10 plasmid pYC1, complete sequence	511340-511369	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP015152	Bacillus thuringiensis strain Bc601 plasmid pBTBC2, complete sequence	52183-52212	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP013056	Bacillus thuringiensis strain YWC2-8 plasmid pYWC2-8-1, complete sequence	150401-150430	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP004861	Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB293, complete sequence	14867-14896	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	CP020755	Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence	221831-221860	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP010091	Bacillus thuringiensis serovar galleriae strain 4G5 plasmid pBMB267, complete sequence	10804-10833	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	NZ_CP021062	Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence	437231-437260	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	MK448735	Streptococcus phage Javan349, complete genome	22794-22823	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	MK448915	Streptococcus phage Javan350, complete genome	24524-24553	8	0.733
NZ_CP041626_1	1.2\|802541\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802541-802570	30	NZ_CP012644	Rufibacter tibetensis strain 1351 plasmid 1, complete sequence	143344-143373	8	0.733
NZ_CP041626_1	1.2\|802541\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802541-802570	30	NZ_CP026319	Vibrio campbellii strain BoB-90 plasmid unnamed 3, complete sequence	50239-50268	8	0.733
NZ_CP041626_1	1.3\|802607\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802607-802636	30	MT586120	Synechococcus phage S-CAM7 isolate 0809CC03, complete genome	18140-18169	8	0.733
NZ_CP041626_1	1.3\|802607\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802607-802636	30	NC_031927	Synechococcus phage S-CAM7 isolate 0910CC49, complete genome	18389-18418	8	0.733
NZ_CP041626_1	1.3\|802607\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802607-802636	30	KU686213	Synechococcus phage S-CAM7 isolate 0910SB42, complete genome	19307-19336	8	0.733
NZ_CP041626_1	1.5\|802739\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802739-802768	30	NC_014824	Ruminococcus albus 7 = DSM 20455 plasmid pRUMAL01, complete sequence	197236-197265	8	0.733
NZ_CP041626_1	1.5\|802739\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802739-802768	30	NZ_CP019438	Thioclava nitratireducens strain 25B10_4 plasmid unnamed1, complete sequence	127327-127356	8	0.733
NZ_CP041626_1	1.1\|802475\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802475-802504	30	JB137888	Sequence 7 from Patent WO2012159774	64231-64260	9	0.7
NZ_CP041626_1	1.4\|802673\|30\|NZ_CP041626\|PILER-CR,CRISPRCasFinder,CRT	802673-802702	30	NZ_CP035407	Bacillus subtilis strain SRCM103612 plasmid unnamed1	31079-31108	9	0.7

1. spacer 1.4|802673|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP010312 (Geoalkalibacter subterraneus strain Red1 plasmid pGSUB1, complete sequence) position: , mismatch: 5, identity: 0.833

cttttga--tgaatttaatgaccatatggcta	CRISPR spacer
--ttggacttgaatttaatgaccatatcggta	Protospacer
  ** **  ****************** * **

2. spacer 1.4|802673|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP047806 (Staphylococcus aureus strain UP_1654 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.8

cttttgatgaatttaatgaccatatggcta---	CRISPR spacer
attttgatgaatttaatgaaca---ggataaag	Protospacer
 ****************** **   ** **

3. spacer 1.5|802739|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NC_023688 (Aeromonas phage PX29, complete genome) position: , mismatch: 6, identity: 0.8

tgcatcatgtcgaagatgaacagattaggg	CRISPR spacer
cgcattatgtcgaagatgaaaagattcgaa	Protospacer
.****.************** ***** *..

4. spacer 1.5|802739|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to MH791401 (UNVERIFIED: Aeromonas phage AsFcp_2, complete genome) position: , mismatch: 6, identity: 0.8

tgcatcatgtcgaagatgaacagattaggg	CRISPR spacer
cgcattatgtcgaagatgaaaagattcgaa	Protospacer
.****.************** ***** *..

5. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NC_019290 (Periwinkle little leaf phytoplasma plasmid pPLLHn-1, complete sequence) position: , mismatch: 7, identity: 0.767

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
agatgaagagttggatgaggaagaagaatt	Protospacer
 * ************ * *********

6. spacer 1.5|802739|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to CP018841 (Staphylococcus phage HOB 14.1.R1, complete genome) position: , mismatch: 7, identity: 0.767

tgcatcatgtcgaagatgaacagattaggg	CRISPR spacer
gtaagcaactcgaagatgaacagaataggg	Protospacer
   * **  *************** *****

7. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NC_018516 (Bacillus thuringiensis HD-789 plasmid pBTHD789-1, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
tgaggaagagttggaagaggaagaagagtc	Protospacer
.*  ***********.* *********

8. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053970 (Bacillus thuringiensis strain FDAARGOS_796 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
tgaggaagagttggaagaggaagaagagtc	Protospacer
.*  ***********.* *********

9. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053979 (Bacillus thuringiensis strain FDAARGOS_795 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
tgaggaagagttggaagaggaagaagagtc	Protospacer
.*  ***********.* *********

10. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013277 (Bacillus thuringiensis serovar israelensis strain AM65-52 plasmid pAM65-52-2-350K, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
tgaggaagagttggaagaggaagaagagtc	Protospacer
.*  ***********.* *********

11. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039723 (Bacillus thuringiensis strain BT-59 plasmid p2, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
tgaggaagagttggaagaggaagaagagtc	Protospacer
.*  ***********.* *********

12. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009348 (Bacillus thuringiensis HD1002 plasmid 2, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
tgaggaagagttggaagaggaagaagagtc	Protospacer
.*  ***********.* *********

13. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009334 (Bacillus thuringiensis strain HD1011 plasmid 2, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
tgaggaagagttggaagaggaagaagagtc	Protospacer
.*  ***********.* *********

14. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045024 (Bacillus thuringiensis strain JW-1 plasmid p2, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
tgaggaagagttggaagaggaagaagagtc	Protospacer
.*  ***********.* *********

15. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP004876 (Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB299, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gattgaacagttggaggtggaaaaatgttt	Protospacer
 .***** **************.** .*

16. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NC_017203 (Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gattgaacagttggaggtggaaaaatgttt	Protospacer
 .***** **************.** .*

17. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NC_020384 (Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-285, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gattgaacagttggaggtggaaaaatgttt	Protospacer
 .***** **************.** .*

18. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011350 (Bacillus thuringiensis strain YC-10 plasmid pYC1, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gattgaacagttggaggtggaaaaatgttt	Protospacer
 .***** **************.** .*

19. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015152 (Bacillus thuringiensis strain Bc601 plasmid pBTBC2, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gattgaacagttggaggtggaaaaatgttt	Protospacer
 .***** **************.** .*

20. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013056 (Bacillus thuringiensis strain YWC2-8 plasmid pYWC2-8-1, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gattgaacagttggaggtggaaaaatgttt	Protospacer
 .***** **************.** .*

21. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP004861 (Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB293, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gattgaacagttggaggtggaaaaatgttt	Protospacer
 .***** **************.** .*

22. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to CP020755 (Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gattgaacagttggaggtggaaaaatgttt	Protospacer
 .***** **************.** .*

23. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP010091 (Bacillus thuringiensis serovar galleriae strain 4G5 plasmid pBMB267, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gattgaacagttggaggtggaaaaatgttt	Protospacer
 .***** **************.** .*

24. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021062 (Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gattgaacagttggaggtggaaaaatgttt	Protospacer
 .***** **************.** .*

25. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to MK448735 (Streptococcus phage Javan349, complete genome) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gtttgaagatttggaagtggaagaactttt	Protospacer
  ******* *****.*********  *

26. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to MK448915 (Streptococcus phage Javan350, complete genome) position: , mismatch: 8, identity: 0.733

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
gtttgaagatttggaagtggaagaactttt	Protospacer
  ******* *****.*********  *

27. spacer 1.2|802541|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012644 (Rufibacter tibetensis strain 1351 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.733

tggtattctagcaagtcatcaaggaaataa	CRISPR spacer
actaaatctagcaagccatcaaggaagtag	Protospacer
    * *********.**********.**.

28. spacer 1.2|802541|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026319 (Vibrio campbellii strain BoB-90 plasmid unnamed 3, complete sequence) position: , mismatch: 8, identity: 0.733

tggtattctagcaagtcatcaaggaaataa	CRISPR spacer
ctaaaacctagcaagtcatcgagtaaataa	Protospacer
. . * .*************.** ******

29. spacer 1.3|802607|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to MT586120 (Synechococcus phage S-CAM7 isolate 0809CC03, complete genome) position: , mismatch: 8, identity: 0.733

cggccagagattaaagaggattacctcaga	CRISPR spacer
gcgccagagaataaagaggattattttcta	Protospacer
  ******** ************..*.  *

30. spacer 1.3|802607|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NC_031927 (Synechococcus phage S-CAM7 isolate 0910CC49, complete genome) position: , mismatch: 8, identity: 0.733

cggccagagattaaagaggattacctcaga	CRISPR spacer
gcgccagagaataaagaggattattttcta	Protospacer
  ******** ************..*.  *

31. spacer 1.3|802607|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to KU686213 (Synechococcus phage S-CAM7 isolate 0910SB42, complete genome) position: , mismatch: 8, identity: 0.733

cggccagagattaaagaggattacctcaga	CRISPR spacer
gcgccagagaataaagaggattattttcta	Protospacer
  ******** ************..*.  *

32. spacer 1.5|802739|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NC_014824 (Ruminococcus albus 7 = DSM 20455 plasmid pRUMAL01, complete sequence) position: , mismatch: 8, identity: 0.733

tgcatcatgtcgaagatgaacagattaggg	CRISPR spacer
gtgatttcatcgaagatgaacagcttaggg	Protospacer
   **. ..************** ******

33. spacer 1.5|802739|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019438 (Thioclava nitratireducens strain 25B10_4 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tgcatcatgtcgaagatgaacagattaggg	CRISPR spacer
atcatccggtcgaagatgaacagatcgtag	Protospacer
  ****  *****************.. .*

34. spacer 1.1|802475|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to JB137888 (Sequence 7 from Patent WO2012159774) position: , mismatch: 9, identity: 0.7

cgttgaagagttggaggtggaagaagatga	CRISPR spacer
tattgaagaattggaggcggaagaatgaac	Protospacer
..*******.*******.******* . .

35. spacer 1.4|802673|30|NZ_CP041626|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035407 (Bacillus subtilis strain SRCM103612 plasmid unnamed1) position: , mismatch: 9, identity: 0.7

cttttgatgaatttaatgaccatatggcta	CRISPR spacer
ttgaagatgaatttattgaccatatgagac	Protospacer
.*   ********** **********.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

553014 : 559910

Clostridium_phage(33.33%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_143333180.1\|553014_553854_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	6.3e-22	31.8
WP_143333181.1\|553979_554357_-	helix-turn-helix domain-containing protein	A0A090D830	Clostridium_phage	1.5e-10	44.0
WP_143333182.1\|554527_554737_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_112779660.1\|554791_555094_+	DUF771 domain-containing protein	A0A1Q1PW00	Staphylococcus_phage	9.5e-05	34.3
WP_143333183.1\|555771_556119_-	hypothetical protein	NA	NA	NA	NA
WP_143333184.1\|556263_557094_+	AAA family ATPase	E2ELL2	Clostridium_phage	1.2e-12	31.9
WP_143333185.1\|557096_557339_+	hypothetical protein	NA	NA	NA	NA
WP_143333186.1\|557527_558481_+	DnaD domain protein	A0A2H4JAS0	uncultured_Caudovirales_phage	4.0e-25	26.7
WP_143333187.1\|558530_558749_+	hypothetical protein	NA	NA	NA	NA
WP_143333188.1\|558784_559057_+	hypothetical protein	NA	NA	NA	NA
WP_143333189.1\|559091_559910_+	ATP-binding protein	F0PII2	Enterococcus_phage	1.5e-36	33.9

DBSCAN-SWA_2

817574 : 829979

Bacillus_virus(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_111950375.1\|817574_818513_+	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	1.1e-94	55.8
WP_143333311.1\|818601_820326_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	1.8e-172	51.8
WP_143333312.1\|820360_821251_+	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	1.9e-08	32.2
WP_077862225.1\|821247_822276_+	uridine diphosphate-N-acetylglucosamine-binding protein YvcK	A1IMD5	Streptococcus_phage	1.8e-95	55.0
WP_077862226.1\|822313_823237_+	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	3.9e-49	37.7
WP_004636505.1\|823329_823923_+	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	7.5e-54	54.2
WP_143333313.1\|824512_826438_+\|tRNA	threonine--tRNA ligase	A0A2K9L297	Tupanvirus	2.1e-113	37.3
WP_143333314.1\|826561_827824_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_143333315.1\|827839_828400_+	IDEAL domain-containing protein	G3MAV7	Bacillus_virus	6.5e-23	36.4
WP_143333316.1\|828409_828766_+	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_112787483.1\|828752_829979_+\|tRNA	CCA tRNA nucleotidyltransferase	G3MAR3	Bacillus_virus	9.2e-38	30.4

DBSCAN-SWA_3

1689077 : 1697809

Moraxella_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_143333719.1\|1689077_1690175_-	DUF262 domain-containing protein	A0A0R6PKN1	Moraxella_phage	1.4e-16	25.7
WP_143333720.1\|1690390_1690720_-	hypothetical protein	NA	NA	NA	NA
WP_143333721.1\|1691257_1691599_-	hypothetical protein	E5DQ16	Aeromonas_phage	2.8e-05	35.2
WP_035516820.1\|1691628_1691832_-	helix-turn-helix transcriptional regulator	A0A2K5B261	Erysipelothrix_phage	6.8e-15	59.7
WP_143333722.1\|1692068_1692320_-	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_143333909.1\|1692754_1694344_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	4.2e-19	34.3
WP_143333723.1\|1694518_1695268_-	hypothetical protein	NA	NA	NA	NA
WP_004636928.1\|1695251_1695995_-	ABC transporter permease	NA	NA	NA	NA
WP_143333724.1\|1695975_1696908_-	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	7.9e-42	42.6
WP_143333910.1\|1697098_1697809_+	response regulator	W8CYM9	Bacillus_phage	2.7e-34	36.6

DBSCAN-SWA_4

1900514 : 1956160

Streptococcus_phage(31.03%)

capsid,head,terminase,tail,protease,tRNA,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_111974311.1\|1900514_1902401_-\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	NA	NA	NA	NA
WP_143333915.1\|1902555_1903938_-\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	NA	NA	NA	NA
WP_143333795.1\|1904328_1905351_+	zinc ABC transporter solute-binding protein	NA	NA	NA	NA
WP_077862980.1\|1905365_1906151_+	metal ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.3e-13	31.4
WP_004635459.1\|1906143_1907061_+	metal ABC transporter permease	NA	NA	NA	NA
WP_111974315.1\|1907057_1907912_+	metal ABC transporter permease	NA	NA	NA	NA
WP_004635457.1\|1908304_1908979_-	AAA family ATPase	W6JKT0	Anomala_cuprea_entomopoxvirus	3.1e-11	27.4
WP_143333796.1\|1908990_1909728_-	hypothetical protein	NA	NA	NA	NA
WP_143333797.1\|1910539_1912165_-	ATP-binding cassette domain-containing protein	A0A1V0SE00	Indivirus	2.1e-21	30.4
WP_077862985.1\|1912360_1913239_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_143333798.1\|1913418_1916463_-	pneumococcal-type histidine triad protein	NA	NA	NA	NA
WP_077862987.1\|1916466_1917399_-	zinc ABC transporter solute-binding protein	NA	NA	NA	NA
WP_143333799.1\|1917735_1918539_+\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_143333800.1\|1918642_1919098_-	hypothetical protein	NA	NA	NA	NA
WP_143333801.1\|1919212_1919455_-	hypothetical protein	NA	NA	NA	NA
WP_004635433.1\|1919767_1920733_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A096XT60	Enterococcus_phage	8.6e-124	65.7
WP_143333802.1\|1920744_1922913_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	1.3e-260	64.2
WP_004635429.1\|1923024_1923417_-	ribonucleotide reductase stimulatory protein NrdI	A0A1W6JL40	Lactococcus_phage	4.0e-11	31.7
WP_004635426.1\|1923418_1923640_-	glutaredoxin-like protein NrdH	A0A166YAI3	Gordonia_phage	8.2e-06	41.8
WP_143333803.1\|1924012_1924612_-	AP2 domain-containing protein	A0A0U4II26	Bacillus_phage	1.7e-13	27.6
WP_143333804.1\|1924785_1925130_+	hypothetical protein	NA	NA	NA	NA
WP_143333805.1\|1925144_1925522_+	hypothetical protein	A0A240FHV6	Streptococcus_phage	6.3e-30	55.2
WP_111950506.1\|1925523_1925745_+	hypothetical protein	NA	NA	NA	NA
WP_143333916.1\|1925804_1926983_+	DEAD/DEAH box helicase	A0A220GFH1	Streptococcus_phage	7.0e-120	56.6
WP_143333806.1\|1926951_1928235_+	DUF3440 domain-containing protein	L0P6Z6	Lactobacillus_phage	5.4e-57	32.1
WP_077862040.1\|1928231_1928771_+	ParB-like nuclease domain-containing protein	A0A220GKT8	Streptococcus_phage	3.3e-48	57.9
WP_143333807.1\|1928757_1929222_+	hypothetical protein	NA	NA	NA	NA
WP_143333808.1\|1929314_1929659_+	hypothetical protein	NA	NA	NA	NA
WP_143333809.1\|1930176_1930380_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_143333810.1\|1930807_1931794_-	hypothetical protein	Q6E4B1	Enterococcus_sp._phage	1.7e-05	40.7
WP_143333811.1\|1931797_1932805_-	hypothetical protein	NA	NA	NA	NA
WP_143333812.1\|1932808_1933075_-	hypothetical protein	NA	NA	NA	NA
WP_143333813.1\|1933058_1933439_-	hypothetical protein	NA	NA	NA	NA
WP_143333814.1\|1933486_1933771_-	hypothetical protein	NA	NA	NA	NA
WP_143333815.1\|1933772_1934201_-	hypothetical protein	NA	NA	NA	NA
WP_143333816.1\|1934206_1934650_-	DUF1617 family protein	NA	NA	NA	NA
WP_143333817.1\|1934636_1936700_-	hypothetical protein	Q38355	Lactococcus_phage	2.3e-09	61.0
WP_112790470.1\|1936719_1937067_-	hypothetical protein	NA	NA	NA	NA
WP_112790469.1\|1937111_1937483_-	hypothetical protein	NA	NA	NA	NA
WP_143333818.1\|1937486_1939064_-	hypothetical protein	A3F657	Streptococcus_phage	1.7e-07	47.5
WP_143333819.1\|1939064_1941260_-	hypothetical protein	A1EAB2	Streptococcus_phage	4.5e-112	51.4
WP_143333820.1\|1941256_1942024_-\|tail	phage tail family protein	NA	NA	NA	NA
WP_143333821.1\|1942035_1945677_-	tape measure protein	D7RWD8	Brochothrix_phage	9.6e-67	49.2
WP_143333822.1\|1945677_1945998_-	hypothetical protein	NA	NA	NA	NA
WP_077862072.1\|1946051_1946471_-	hypothetical protein	O34069	Streptococcus_phage	2.9e-12	35.0
WP_077862071.1\|1946532_1947063_-\|tail	phage major tail protein, TP901-1 family	Q6SEC7	Lactobacillus_prophage	2.0e-26	38.6
WP_077862070.1\|1947076_1947463_-	DUF3168 domain-containing protein	A0A0P0I3C8	Lactobacillus_phage	1.8e-11	29.0
WP_143333823.1\|1947462_1947807_-	HK97 gp10 family phage protein	A0A097BYB8	Leuconostoc_phage	4.2e-17	40.2
WP_143333824.1\|1947807_1948098_-	hypothetical protein	NA	NA	NA	NA
WP_143333825.1\|1948100_1948427_-\|head,tail	phage head-tail connector protein	A0A2P1JTX2	Anoxybacillus_phage	2.9e-15	45.5
WP_143333826.1\|1948416_1948695_-	Rho termination protein	Q4ZCE7	Staphylococcus_virus	3.2e-15	48.4
WP_143333827.1\|1948707_1949787_-\|capsid	major capsid protein E	A0A2H4J022	uncultured_Caudovirales_phage	8.2e-99	54.4
WP_111950535.1\|1949790_1950147_-	hypothetical protein	W6LM71	Streptococcus_phage	5.6e-12	38.3
WP_143333828.1\|1950149_1950731_-	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_143333829.1\|1950851_1951067_-	hypothetical protein	NA	NA	NA	NA
WP_112787424.1\|1951259_1951472_-	hypothetical protein	NA	NA	NA	NA
WP_143333830.1\|1951452_1953084_-	hypothetical protein	A0A2P1JTW9	Anoxybacillus_phage	9.3e-54	37.9
WP_143333831.1\|1953055_1954453_-\|portal	phage portal protein	A0A2P1JTZ3	Anoxybacillus_phage	4.4e-105	45.9
WP_143333917.1\|1954449_1955619_-\|terminase	PBSX family phage terminase large subunit	M1PG09	Streptococcus_phage	9.0e-144	65.3
WP_143333832.1\|1955677_1956160_-\|terminase	terminase	A0A1S5SA53	Streptococcus_phage	7.7e-41	58.7

DBSCAN-SWA_5

1965392 : 2008878

Streptococcus_phage(31.25%)

capsid,head,terminase,tail,integrase,portal

attL 1958736:1958795|attR 2011454:2013028

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1958736:1958795	attL	NA	NA	NA	NA
WP_143333847.1\|1965392_1966973_-	DEAD/DEAH box helicase family protein	Q5YA94	Bacillus_phage	3.0e-198	64.6
WP_143333848.1\|1966984_1967464_-	DUF669 domain-containing protein	Q5YA95	Bacillus_phage	2.6e-28	49.6
WP_143333849.1\|1967466_1968615_-	AAA family ATPase	A0A097BY66	Enterococcus_phage	1.6e-81	45.3
WP_143333850.1\|1968614_1969934_-	AAA family ATPase	Q5YA97	Bacillus_phage	2.5e-118	62.4
WP_143333851.1\|1969920_1970154_-	hypothetical protein	NA	NA	NA	NA
WP_143333852.1\|1970146_1970326_-	hypothetical protein	NA	NA	NA	NA
WP_143333853.1\|1970326_1970629_-	DUF771 domain-containing protein	A0A0D4DD43	Staphylococcus_phage	2.0e-07	27.3
WP_143333854.1\|1970729_1971089_+	hypothetical protein	NA	NA	NA	NA
WP_077862001.1\|1971779_1972016_-	helix-turn-helix transcriptional regulator	A0A2H4J9X2	uncultured_Caudovirales_phage	1.0e-14	54.5
WP_143333855.1\|1972204_1972828_+	helix-turn-helix domain-containing protein	A0A1B2APZ3	Phage_Wrath	1.8e-42	48.3
WP_143333856.1\|1972857_1973829_+	HNH endonuclease	F5B475	Synechococcus_phage	1.6e-08	47.8
WP_143333857.1\|1973969_1975076_+	hypothetical protein	A0A141E0C6	Streptococcus_phage	1.0e-72	41.8
WP_143333858.1\|1975398_1976505_+\|integrase	tyrosine-type recombinase/integrase	A8ATX2	Listeria_phage	4.7e-49	34.6
WP_143333803.1\|1976730_1977330_-	AP2 domain-containing protein	A0A0U4II26	Bacillus_phage	1.7e-13	27.6
WP_143333804.1\|1977503_1977848_+	hypothetical protein	NA	NA	NA	NA
WP_143333805.1\|1977862_1978240_+	hypothetical protein	A0A240FHV6	Streptococcus_phage	6.3e-30	55.2
WP_111950506.1\|1978241_1978463_+	hypothetical protein	NA	NA	NA	NA
WP_143333916.1\|1978522_1979701_+	DEAD/DEAH box helicase	A0A220GFH1	Streptococcus_phage	7.0e-120	56.6
WP_143333806.1\|1979669_1980953_+	DUF3440 domain-containing protein	L0P6Z6	Lactobacillus_phage	5.4e-57	32.1
WP_077862040.1\|1980949_1981489_+	ParB-like nuclease domain-containing protein	A0A220GKT8	Streptococcus_phage	3.3e-48	57.9
WP_143333807.1\|1981475_1981940_+	hypothetical protein	NA	NA	NA	NA
WP_143333808.1\|1982032_1982377_+	hypothetical protein	NA	NA	NA	NA
WP_143333809.1\|1982894_1983098_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_143333810.1\|1983525_1984512_-	hypothetical protein	Q6E4B1	Enterococcus_sp._phage	1.7e-05	40.7
WP_143333811.1\|1984515_1985523_-	hypothetical protein	NA	NA	NA	NA
WP_143333812.1\|1985526_1985793_-	hypothetical protein	NA	NA	NA	NA
WP_143333813.1\|1985776_1986157_-	hypothetical protein	NA	NA	NA	NA
WP_143333814.1\|1986204_1986489_-	hypothetical protein	NA	NA	NA	NA
WP_143333815.1\|1986490_1986919_-	hypothetical protein	NA	NA	NA	NA
WP_143333816.1\|1986924_1987368_-	DUF1617 family protein	NA	NA	NA	NA
WP_143333817.1\|1987354_1989418_-	hypothetical protein	Q38355	Lactococcus_phage	2.3e-09	61.0
WP_112790470.1\|1989437_1989785_-	hypothetical protein	NA	NA	NA	NA
WP_112790469.1\|1989829_1990201_-	hypothetical protein	NA	NA	NA	NA
WP_143333818.1\|1990204_1991782_-	hypothetical protein	A3F657	Streptococcus_phage	1.7e-07	47.5
WP_143333819.1\|1991782_1993978_-	hypothetical protein	A1EAB2	Streptococcus_phage	4.5e-112	51.4
WP_143333820.1\|1993974_1994742_-\|tail	phage tail family protein	NA	NA	NA	NA
WP_143333821.1\|1994753_1998395_-	tape measure protein	D7RWD8	Brochothrix_phage	9.6e-67	49.2
WP_143333822.1\|1998395_1998716_-	hypothetical protein	NA	NA	NA	NA
WP_077862072.1\|1998769_1999189_-	hypothetical protein	O34069	Streptococcus_phage	2.9e-12	35.0
WP_077862071.1\|1999250_1999781_-\|tail	phage major tail protein, TP901-1 family	Q6SEC7	Lactobacillus_prophage	2.0e-26	38.6
WP_077862070.1\|1999794_2000181_-	DUF3168 domain-containing protein	A0A0P0I3C8	Lactobacillus_phage	1.8e-11	29.0
WP_143333823.1\|2000180_2000525_-	HK97 gp10 family phage protein	A0A097BYB8	Leuconostoc_phage	4.2e-17	40.2
WP_143333824.1\|2000525_2000816_-	hypothetical protein	NA	NA	NA	NA
WP_143333825.1\|2000818_2001145_-\|head,tail	phage head-tail connector protein	A0A2P1JTX2	Anoxybacillus_phage	2.9e-15	45.5
WP_143333826.1\|2001134_2001413_-	Rho termination protein	Q4ZCE7	Staphylococcus_virus	3.2e-15	48.4
WP_143333827.1\|2001425_2002505_-\|capsid	major capsid protein E	A0A2H4J022	uncultured_Caudovirales_phage	8.2e-99	54.4
WP_111950535.1\|2002508_2002865_-	hypothetical protein	W6LM71	Streptococcus_phage	5.6e-12	38.3
WP_143333828.1\|2002867_2003449_-	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_143333829.1\|2003569_2003785_-	hypothetical protein	NA	NA	NA	NA
WP_112787424.1\|2003977_2004190_-	hypothetical protein	NA	NA	NA	NA
WP_143333830.1\|2004170_2005802_-	hypothetical protein	A0A2P1JTW9	Anoxybacillus_phage	9.3e-54	37.9
WP_143333831.1\|2005773_2007171_-\|portal	phage portal protein	A0A2P1JTZ3	Anoxybacillus_phage	4.4e-105	45.9
WP_143333917.1\|2007167_2008337_-\|terminase	PBSX family phage terminase large subunit	M1PG09	Streptococcus_phage	9.0e-144	65.3
WP_143333832.1\|2008395_2008878_-\|terminase	terminase	A0A1S5SA53	Streptococcus_phage	7.7e-41	58.7
2011454:2013028	attR	NA	NA	NA	NA

DBSCAN-SWA_6

2018110 : 2061596

Streptococcus_phage(31.25%)

capsid,head,terminase,tail,integrase,portal

attL 2011454:2011513|attR 2064172:2065746

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2011454:2011513	attL	NA	NA	NA	NA
WP_143333847.1\|2018110_2019691_-	DEAD/DEAH box helicase family protein	Q5YA94	Bacillus_phage	3.0e-198	64.6
WP_143333848.1\|2019702_2020182_-	DUF669 domain-containing protein	Q5YA95	Bacillus_phage	2.6e-28	49.6
WP_143333849.1\|2020184_2021333_-	AAA family ATPase	A0A097BY66	Enterococcus_phage	1.6e-81	45.3
WP_143333850.1\|2021332_2022652_-	AAA family ATPase	Q5YA97	Bacillus_phage	2.5e-118	62.4
WP_143333851.1\|2022638_2022872_-	hypothetical protein	NA	NA	NA	NA
WP_143333852.1\|2022864_2023044_-	hypothetical protein	NA	NA	NA	NA
WP_143333853.1\|2023044_2023347_-	DUF771 domain-containing protein	A0A0D4DD43	Staphylococcus_phage	2.0e-07	27.3
WP_143333854.1\|2023447_2023807_+	hypothetical protein	NA	NA	NA	NA
WP_077862001.1\|2024497_2024734_-	helix-turn-helix transcriptional regulator	A0A2H4J9X2	uncultured_Caudovirales_phage	1.0e-14	54.5
WP_143333855.1\|2024922_2025546_+	helix-turn-helix domain-containing protein	A0A1B2APZ3	Phage_Wrath	1.8e-42	48.3
WP_143333856.1\|2025575_2026547_+	HNH endonuclease	F5B475	Synechococcus_phage	1.6e-08	47.8
WP_143333857.1\|2026687_2027794_+	hypothetical protein	A0A141E0C6	Streptococcus_phage	1.0e-72	41.8
WP_143333858.1\|2028116_2029223_+\|integrase	tyrosine-type recombinase/integrase	A8ATX2	Listeria_phage	4.7e-49	34.6
WP_143333803.1\|2029448_2030048_-	AP2 domain-containing protein	A0A0U4II26	Bacillus_phage	1.7e-13	27.6
WP_143333804.1\|2030221_2030566_+	hypothetical protein	NA	NA	NA	NA
WP_143333805.1\|2030580_2030958_+	hypothetical protein	A0A240FHV6	Streptococcus_phage	6.3e-30	55.2
WP_111950506.1\|2030959_2031181_+	hypothetical protein	NA	NA	NA	NA
WP_143333916.1\|2031240_2032419_+	DEAD/DEAH box helicase	A0A220GFH1	Streptococcus_phage	7.0e-120	56.6
WP_143333806.1\|2032387_2033671_+	DUF3440 domain-containing protein	L0P6Z6	Lactobacillus_phage	5.4e-57	32.1
WP_077862040.1\|2033667_2034207_+	ParB-like nuclease domain-containing protein	A0A220GKT8	Streptococcus_phage	3.3e-48	57.9
WP_143333807.1\|2034193_2034658_+	hypothetical protein	NA	NA	NA	NA
WP_143333808.1\|2034750_2035095_+	hypothetical protein	NA	NA	NA	NA
WP_143333809.1\|2035612_2035816_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_143333810.1\|2036243_2037230_-	hypothetical protein	Q6E4B1	Enterococcus_sp._phage	1.7e-05	40.7
WP_143333811.1\|2037233_2038241_-	hypothetical protein	NA	NA	NA	NA
WP_143333812.1\|2038244_2038511_-	hypothetical protein	NA	NA	NA	NA
WP_143333813.1\|2038494_2038875_-	hypothetical protein	NA	NA	NA	NA
WP_143333814.1\|2038922_2039207_-	hypothetical protein	NA	NA	NA	NA
WP_143333815.1\|2039208_2039637_-	hypothetical protein	NA	NA	NA	NA
WP_143333816.1\|2039642_2040086_-	DUF1617 family protein	NA	NA	NA	NA
WP_143333817.1\|2040072_2042136_-	hypothetical protein	Q38355	Lactococcus_phage	2.3e-09	61.0
WP_112790470.1\|2042155_2042503_-	hypothetical protein	NA	NA	NA	NA
WP_112790469.1\|2042547_2042919_-	hypothetical protein	NA	NA	NA	NA
WP_143333818.1\|2042922_2044500_-	hypothetical protein	A3F657	Streptococcus_phage	1.7e-07	47.5
WP_143333819.1\|2044500_2046696_-	hypothetical protein	A1EAB2	Streptococcus_phage	4.5e-112	51.4
WP_143333820.1\|2046692_2047460_-\|tail	phage tail family protein	NA	NA	NA	NA
WP_143333821.1\|2047471_2051113_-	tape measure protein	D7RWD8	Brochothrix_phage	9.6e-67	49.2
WP_143333822.1\|2051113_2051434_-	hypothetical protein	NA	NA	NA	NA
WP_077862072.1\|2051487_2051907_-	hypothetical protein	O34069	Streptococcus_phage	2.9e-12	35.0
WP_077862071.1\|2051968_2052499_-\|tail	phage major tail protein, TP901-1 family	Q6SEC7	Lactobacillus_prophage	2.0e-26	38.6
WP_077862070.1\|2052512_2052899_-	DUF3168 domain-containing protein	A0A0P0I3C8	Lactobacillus_phage	1.8e-11	29.0
WP_143333823.1\|2052898_2053243_-	HK97 gp10 family phage protein	A0A097BYB8	Leuconostoc_phage	4.2e-17	40.2
WP_143333824.1\|2053243_2053534_-	hypothetical protein	NA	NA	NA	NA
WP_143333825.1\|2053536_2053863_-\|head,tail	phage head-tail connector protein	A0A2P1JTX2	Anoxybacillus_phage	2.9e-15	45.5
WP_143333826.1\|2053852_2054131_-	Rho termination protein	Q4ZCE7	Staphylococcus_virus	3.2e-15	48.4
WP_143333827.1\|2054143_2055223_-\|capsid	major capsid protein E	A0A2H4J022	uncultured_Caudovirales_phage	8.2e-99	54.4
WP_111950535.1\|2055226_2055583_-	hypothetical protein	W6LM71	Streptococcus_phage	5.6e-12	38.3
WP_143333828.1\|2055585_2056167_-	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_143333829.1\|2056287_2056503_-	hypothetical protein	NA	NA	NA	NA
WP_112787424.1\|2056695_2056908_-	hypothetical protein	NA	NA	NA	NA
WP_143333830.1\|2056888_2058520_-	hypothetical protein	A0A2P1JTW9	Anoxybacillus_phage	9.3e-54	37.9
WP_143333831.1\|2058491_2059889_-\|portal	phage portal protein	A0A2P1JTZ3	Anoxybacillus_phage	4.4e-105	45.9
WP_143333917.1\|2059885_2061055_-\|terminase	PBSX family phage terminase large subunit	M1PG09	Streptococcus_phage	9.0e-144	65.3
WP_143333832.1\|2061113_2061596_-\|terminase	terminase	A0A1S5SA53	Streptococcus_phage	7.7e-41	58.7
2064172:2065746	attR	NA	NA	NA	NA

DBSCAN-SWA_7

2070828 : 2081941

Bacillus_phage(30.0%)

integrase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_143333847.1\|2070828_2072409_-	DEAD/DEAH box helicase family protein	Q5YA94	Bacillus_phage	3.0e-198	64.6
WP_143333848.1\|2072420_2072900_-	DUF669 domain-containing protein	Q5YA95	Bacillus_phage	2.6e-28	49.6
WP_143333849.1\|2072902_2074051_-	AAA family ATPase	A0A097BY66	Enterococcus_phage	1.6e-81	45.3
WP_143333850.1\|2074050_2075370_-	AAA family ATPase	Q5YA97	Bacillus_phage	2.5e-118	62.4
WP_143333851.1\|2075356_2075590_-	hypothetical protein	NA	NA	NA	NA
WP_143333852.1\|2075582_2075762_-	hypothetical protein	NA	NA	NA	NA
WP_143333853.1\|2075762_2076065_-	DUF771 domain-containing protein	A0A0D4DD43	Staphylococcus_phage	2.0e-07	27.3
WP_143333854.1\|2076165_2076525_+	hypothetical protein	NA	NA	NA	NA
WP_077862001.1\|2077215_2077452_-	helix-turn-helix transcriptional regulator	A0A2H4J9X2	uncultured_Caudovirales_phage	1.0e-14	54.5
WP_143333855.1\|2077640_2078264_+	helix-turn-helix domain-containing protein	A0A1B2APZ3	Phage_Wrath	1.8e-42	48.3
WP_143333856.1\|2078293_2079265_+	HNH endonuclease	F5B475	Synechococcus_phage	1.6e-08	47.8
WP_143333857.1\|2079405_2080512_+	hypothetical protein	A0A141E0C6	Streptococcus_phage	1.0e-72	41.8
WP_143333858.1\|2080834_2081941_+\|integrase	tyrosine-type recombinase/integrase	A8ATX2	Listeria_phage	4.7e-49	34.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage