CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP019721	Staphylococcus epidermidis strain NBRC 100911	1 crisprs	csa3,WYL,DEDDh,cas3,DinG	1	1	5	0
NZ_AP019722	Staphylococcus epidermidis strain NBRC 100911 plasmid pSEP1, complete sequence	0 crisprs	NA	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP019721_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019721_1

2365418-2365506

Orphan

Consensus_repeat	Method
CAGTGAAATTCTCTTTGTTGGGACCCCATCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019721_1

>merge|NZ_AP019721|1|2365418-2365506|CRISPRCasFinder
CAGTGAAATTCTCTTTGTTGGGACCCCATCCCCAACTTGCTTTGCTTGTTGAATTTCTCAGTGAAATTCTCTTTGTTGGGGCCCCATCC

>NZ_AP019721|1|1|2365418-2365506|CRISPRCasFinder
CAGTGAAATTCTCTTTGTTGGGACCCCATCC	CCAACTTGCTTTGCTTGTTGAATTTCT
CAGTGAAATTCTCTTTGTTGGGGCCCCATCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019721.1\|WP_002437166.1\|2360585_2361365_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226480
NZ_AP019721.1\|WP_002437170.1\|2361809_2362379_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|211789
NZ_AP019721.1\|WP_001829411.1\|2355642_2356050_+\|general-stress-protein	unknown	unknown	gnl\|CDD\|378584
NZ_AP019721.1\|WP_001831355.1\|2371049_2371241_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019721.1\|WP_001829400.1\|2356177_2356843_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019721.1\|WP_002437175.1\|2364165_2364789_+\|NDxxF-motif-lipoprotein	unknown	unknown	gnl\|CDD\|380196
NZ_AP019721.1\|WP_001831345.1\|2369485_2369782_-\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NZ_AP019721.1\|WP_001832461.1\|2367461_2367716_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NZ_AP019721.1\|WP_002437208.1\|2370166_2370976_+\|lysozyme	unknown	unknown	gnl\|CDD\|119383
NZ_AP019721.1\|WP_001830914.1\|2366355_2366988_-\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_AP019721.1\|WP_002437162.1\|2358179_2359568_+\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
NZ_AP019721.1\|WP_002437172.1\|2362393_2363917_+\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942
NZ_AP019721.1\|WP_002437189.1\|2365744_2366335_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_AP019721.1\|WP_001831333.1\|2368953_2369463_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|168659
NZ_AP019721.1\|WP_001829387.1\|2356968_2357871_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380149
NZ_AP019721.1\|WP_001831354.1\|2368666_2368909_-\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NZ_AP019721.1\|WP_002437185.1\|2365008_2365386_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019721.1\|WP_002437194.1\|2367937_2368198_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019721.1\|WP_001831336.1\|2371473_2372571_-\|redox-regulated-ATPase-YchF	unknown	unknown	gnl\|CDD\|236583
NZ_AP019721.1\|WP_002455899.1\|2359689_2360445_-\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|380322

Protein	Function_ID	Function_description	E-value
NZ_AP019721.1\|WP_002437166.1\|2360585_2361365_+\|hypothetical-protein	gnl\|CDD\|226480	COG3971, COG3971, 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism].	7.67998e-54
NZ_AP019721.1\|WP_002437170.1\|2361809_2362379_+\|peroxiredoxin	gnl\|CDD\|211789	TIGR03137, AhpC, peroxiredoxin. This peroxiredoxin (AhpC, alkylhydroperoxide reductase subunit C) is one subunit of a two-subunit complex with subunit F(TIGR03140). Usually these are found as an apparent operon. The gene has been characterized in Bacteroides fragilis, where it is important in oxidative stress defense. This gene contains two invariant cysteine residues, one near the N-terminus and one near the C-terminus, each followed immediately by a proline residue. [Cellular processes, Detoxification, Cellular processes, Adaptations to atypical conditions].	1.42852e-125
NZ_AP019721.1\|WP_001829411.1\|2355642_2356050_+\|general-stress-protein	gnl\|CDD\|378584	pfam11181, YflT, Heat induced stress protein YflT. YflT is a heat induced protein.	1.18912e-16
NZ_AP019721.1\|WP_002437175.1\|2364165_2364789_+\|NDxxF-motif-lipoprotein	gnl\|CDD\|380196	NF033193, lipo_NDxxF, NDxxF motif lipoprotein. Members of this family are lipoproteins, about 200 amino acids long in precursor form, found in Staphylococcus aureus, Bacillus cereus, and various other Firmicutes. The protein family is named for one of its several highly conserved motifs.	3.08114e-79
NZ_AP019721.1\|WP_001831345.1\|2369485_2369782_-\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	4.8221e-36
NZ_AP019721.1\|WP_002437208.1\|2370166_2370976_+\|lysozyme	gnl\|CDD\|119383	cd06523, GH25_PlyB-like, PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for effective catalytic activity. Endolysins are produced by bacteriophages at the end of their life cycle and participate in lysing the bacterial cell in order to release the newly formed progeny. Endolysins (also referred to as endo-N-acetylmuramidases or peptidoglycan hydrolases) degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.	5.24151e-55
NZ_AP019721.1\|WP_001830914.1\|2366355_2366988_-\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	4.9097e-35
NZ_AP019721.1\|WP_002437162.1\|2358179_2359568_+\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
NZ_AP019721.1\|WP_002437172.1\|2362393_2363917_+\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0
NZ_AP019721.1\|WP_002437189.1\|2365744_2366335_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	6.36506e-46
NZ_AP019721.1\|WP_001829387.1\|2356968_2357871_+\|hypothetical-protein	gnl\|CDD\|380149	NF012181, MSCRAMM_SdrD, MSCRAMM family adhesin SdrD. Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.	0.000708705
NZ_AP019721.1\|WP_001831354.1\|2368666_2368909_-\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	1.06497e-43
NZ_AP019721.1\|WP_001832461.1\|2367461_2367716_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	1.06396e-07
NZ_AP019721.1\|WP_001831333.1\|2368953_2369463_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|168659	PRK06751, PRK06751, single-stranded DNA-binding protein; Provisional.	7.31904e-63
NZ_AP019721.1\|WP_001831336.1\|2371473_2372571_-\|redox-regulated-ATPase-YchF	gnl\|CDD\|236583	PRK09601, PRK09601, redox-regulated ATPase YchF.	0
NZ_AP019721.1\|WP_002455899.1\|2359689_2360445_-\|NADPH-dependent-oxidoreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	5.49022e-90

>NZ_AP019721.1|WP_002437185.1|2365008_2365386_+|hypothetical-protein
MKIRLTFIILAILSTIGLVLVLAKYPTGPHTINYNEPYTVLIAITTIVIMALPALILGIFNHLACRIISAILQISALMMWGFLVIISLIMGQIVIMLMASLTILALLVSSIVTLSVHPSTSDKIN
>NZ_AP019721.1|WP_002437175.1|2364165_2364789_+|NDxxF-motif-lipoprotein
MKKRVITYLILALSLTLAACSNTNDNNNQEHHSNAHAPKNAKTLKEKDIFSSNKKGQKISEKEMKQALEKYLQANSDVLDNKYVMQHKLDKQSDSNPKITESQADRLSKLSNLAVKNDLHFKKFIKNNHIPEEYKDPTDRIINYFHALNSTISNVDEDIEKLNYQPQNSINVVDVPTKYSGDVNKKQQDKITTFLKKKGIDTEVFNK
>NZ_AP019721.1|WP_002437172.1|2362393_2363917_+|alkyl-hydroperoxide-reductase-subunit-F
MLNADLKQQLQQLLELMEGDVEFVASLGSDDKSNELKELLNEMAEMSAHITITEKSLKRTPSFSVNRPGEETGITFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKGLEGPFHFETFVSLTCQKCPDVVQALNLMSVINPNITHTMIDGAVFREESENIMAVPAVFLDGQEFGNGRMTVQDILTKLGSTQDASEFNDKDPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGGQVNDTAGIENFITVKETTGSEFSSNLAEHIAQYDIDTMTGIRATNIEKTDSAIRVTLENDAVLESKTVIISTGASWRKLNIPGEDRLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEAAIDLAGIVKHVTLFEYASELKADSVLQERLRSLPNVDIKTSAKTTEVIGDDYVTGISYEDMTTGESQVVNLDGIFVQIGLVPNTSWLQNAVELNERGEVMINRDNATNVPGIFAAGDVTDQKNKQIIISMGAGANAALNAFDYIIRN
>NZ_AP019721.1|WP_002437170.1|2361809_2362379_+|peroxiredoxin
MSLINKEILPFTAQAYDPKKDEFKEVTQEDFKGSWNVVCFYPADFSFVCPTELEDLQNQYAKLQELGVNVYSVSTDTHFVHKAWHDHSDAISKLEYSMIGDPSQTITRNFDVLDEETGLAQRGTFIIDPDGVVQAAEINADGIGRDASTLVNKIKAAQYVRQHPGEVCPAKWEEGSESLQPGLDLVGKI
>NZ_AP019721.1|WP_002437166.1|2360585_2361365_+|hypothetical-protein
MTLTNKEVAKVLFKAYRYKKPIDFISENYQLNEEEAYHVQEELIDQLTFKDRSTVTGYKVSMTSKATQAIANTNEPAYGTLLSNQIVNDGASVSLSELFSPLLEPEIIFIVQEDLPYDADLETIRYHTRIAPGIEIPDARYKNWFPNFTLSDLISDNTATGLVVVGDPVDGLDNDAFANVHLNLYKDDKCIATGESSKVLGNPLNAIHWLIKKLHTHGKQLKKGDIISSGTFISPLKLEYGTYRAEYSGIGKVSFSVNK
>NZ_AP019721.1|WP_002455899.1|2359689_2360445_-|NADPH-dependent-oxidoreductase
MSDYVYELMKQHHSVRKFKNQPLGSETVEKLVEAGQSASTSSYLQTYSIIGVEDPSIKARLKEVSGQPYVLDNGYLFVFVLDYYRHHLVDEVAASNMETSYGSAEGLLVGTIDVALVAQNMAVAAEDMGYGIVYLGSLRNDVARVREILNLPDYTFPLFGMAVGEPSDEENGSPKPRLPFKHIFHKDQYDANQHQQRKELEAYDQVVSEYYKERTHGVRTENWSQQIETFLGRKTRLDMLDELKKAGFIQR
>NZ_AP019721.1|WP_002437162.1|2358179_2359568_+|L-cystine-transporter
MEILFTVINVIVLLVFLIMLNIMARKHVSFPKRVFTALAIGIVFGIVLHLIYGAESKTLEQSTDWFSIVGDGYVALLQMIVMPLIFISIVAAFSKIQIGEKFAKIGSYIFMFLIGTVAIAAIVGIFYALIFGLDASSIDLGSAEHSRGTEISKQAKDLTANTLPQQILEVFPSNPFLDFTGQRTTSTIAVVIFATFVGFAYLRVARKQPEHGSLLKRGIEAIYSIVMAIVTFVLRLTPYGILAIMASTLATSDFSAIWTLGKFLIASYAALITMYIIHLIILSVLGINPVKYVKKTIEVLIFAFTSRSSAGALPLNVQTQTKRLGVPEGIANFSATFGLSIGQNGCAGIYPAMLAVMVAPVANVEIDFQFVVTLITVVIISSFGVAGVGGGATFASILVLSTLNLPVALAGVLISIEPLIDMGRTALNVNDSMLAGTGTARLTNHWDKKTFDSNDYGDLSAN
>NZ_AP019721.1|WP_001829387.1|2356968_2357871_+|hypothetical-protein
MLTKEFAQRVELSEKQVRKIVQHLEERGYHLSKTEYRGREATDFKEDDIELFTDIANKVKQTNSYDLAFEELEKEKDFLQVIVKDEDSQLPTDQNVAQLVEDLRSEIQKMREERQMLGQMINQVHQQQQELKELQTDITTKLDSNAQSLKSIQNSQEAIQSAQEQQSKDIAKANELKDSELRSHFDSMSNSASISQSNVASQSTTASLSQSESANDSMSSSLSESNSITSESNTNSKSEIESKSTSTSEFLSESGSVSNSEKSESISHSQSTSATPSSQSTYQQQPKEEKKGFFARLFNL
>NZ_AP019721.1|WP_001829400.1|2356177_2356843_+|hypothetical-protein
MEFKVIESAKDPLFNEALKLYDDKLDIGLDEDSKIFKRSLENNKTENDYAFIVGIENQTVVSLATAHYEATTNSAFLIYLIAKESPNHDERMSLTLEAIEKQLNLLSQEVHNRDINFIMLEVPKEPSTANIDDKLRNALEHRRQFLFENQFEKQDDIDYIHPNQNQEETPQKVDLFIKANIELTKDIYGTSVKSNYILKYVFANGISREIIYPLLKEMNLR
>NZ_AP019721.1|WP_001829411.1|2355642_2356050_+|general-stress-protein
MAKITVVNNQDELYKVINQKKSEGYLETELAVISKSKLHLDDLHNSQISLMATSGSFSDRMSRLLTGEDGEETVLSRYDLTDNELEGYKQDILNDKMLVVANSDRSSHDEVEDNNAAYKEVDITHYAAESEGPKA
>NZ_AP019721.1|WP_002437189.1|2365744_2366335_-|histidine-phosphatase-family-protein
MEIYLVRHGESQSNYDNKHGYLYFCGQLDVPLTERGIKSAKELSVYFKNKYIDNVYVSDLKRTRQTYEELFPYDIPTIYTKTLRERSLGVFEGKNKEEVCKDKRFEKYFRDPNYKYFRHSFSQKAPQGESYQHVYDRVVTFIENELNQQQRRVVIVAHQVVIRCFFVYFKMITKEEALATEIHNCYPYLIKKEMKF
>NZ_AP019721.1|WP_001830914.1|2366355_2366988_-|LysE-family-translocator
MDGLITFIIITLLIIIVPGPDFIIVMKNTINSSKMNGFMAAFGITTGHILYSSLAIFGIIYILTSLHFVFLTIKILGACYLIYLGIKSILSAHSSVDFSKQALADVRNVSYITSFRQGFLSTSLNPKALLFYVSIFPQFLSNGNIHMKSEVALFAFSVVVVICLWFLFCVFIFQYIKLLFSRPRFKAIFDYIVGFVLIGLSINLLLSKSS
>NZ_AP019721.1|WP_001832461.1|2367461_2367716_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MFGLIGMIIVGGIIGWIAGLILGKDVPGGILGNIIAGIVGSWVGTMILGEWGPQLGKIHIFPALLGSIILIFIISLILKALRKK
>NZ_AP019721.1|WP_002437194.1|2367937_2368198_+|hypothetical-protein
MQHKNKFQRINQIIQIIGFLSFLAILTIITLNFFIKGHLQGHFEIGFNIQSNQVYVVTTLIIVTIICTILSAILNMLSNKKQNYKH
>NZ_AP019721.1|WP_001831354.1|2368666_2368909_-|30S-ribosomal-protein-S18
MAGGPRRGGRRRKKVCYFTANGITHIDYKDTELLKRFISERGKILPRRVTGTSAKYQRMLTTAIKRARHMALLPYVKEEQ
>NZ_AP019721.1|WP_001831333.1|2368953_2369463_-|single-stranded-DNA-binding-protein
MLNRVVLVGRLTKDPEYRTTPSGVSVATFTLAVNRTFTNAQGEREADFINCVVFRRQAENVNNYLSKGSLAGVDGRIQSRSYENQEGRRIFVTEVVCDSVQFLEPKNAQHGGQRSQNNNFQDYGQGFGGQQSGQNTSYNNNNSSNSNQSDNPFANANGPIDISDDDLPF
>NZ_AP019721.1|WP_001831345.1|2369485_2369782_-|30S-ribosomal-protein-S6
MRTYEIMYIVRPNIEEDAKKALVERFNGILASEGSEVLEEKDWGKRRLAYEINDFKEGFYNIVRIKTDNNKSTDEFQRLAKINDDIIRYIVIREDQDK
>NZ_AP019721.1|WP_002437208.1|2370166_2370976_+|lysozyme
MLKKFSYSIISLSIFATSLNFIDTQAQASSSSVSEKGTMGYGYQQYLKDHPKKQPHKTQNRSTFSAESNITETNNGERVLDISEWQGLLTNEQIKQLKKNYDFIILRAQYGSEYVDKTFEKNAELLEQNKMKYGVYSYSMYESPKDARYEANTLSQRAPKAAFYINDYEEQTVKSGDDETATQAWANEMRKLAGNKKILFYSYENFMLNHASNAVSSYDGYWLAAYQAEEPNREKVLWQYTNSYYSPELNQNVDANYIDENVNSSWFTS
>NZ_AP019721.1|WP_001831355.1|2371049_2371241_+|hypothetical-protein
MRLNLDWNKDFQEFQDILNSGIHPEWLYCAKANLVLEPAYTGEGKQFFSTQDIIKASKIIPFF
>NZ_AP019721.1|WP_001831336.1|2371473_2372571_-|redox-regulated-ATPase-YchF
MALTAGIVGLPNVGKSTLFNAITKAGALAANYPFATIDPNVGIVEVPDSRLIKLEEMVQPKKTIPTTFEFTDIAGIVKGASKGEGLGNKFLSHIREVDAICQVVRAFDDENVTHVSGRVNPLDDIEVINMELVLADLESVEKRLPKIEKMARQKDKTAEMELRILTQIKEALEDGKPVRSIDFNEDDQKWVNQAQLLTSKKMLYIANVGEDEIGDKDNDKVKAIREYAANEDSEVIVISAKIEEEIATLDDEDKEMFLEDLGIEEPGLDRLIRTTYDLLGLSTYFTAGVQEVRAWTFKQGMTAPQCAGIIHTDFERGFIRAEVTSYEDYVQHGGENGAKEAGRQRLEGKDYIMQDGDIVHFRFNV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_AP019721.1	958817-958843	2	0.926
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_AP019721.1	958875-958901	2	0.926
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_AP019721.1	1194556-1194582	2	0.926
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_AP019721.1	2090200-2090226	2	0.926
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_AP019721.1	2305138-2305164	2	0.926

1. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to position: 958817-958843, mismatch: 2, identity: 0.926

ccaacttgctttgcttgttgaatttct	CRISPR spacer
ccaacttgctttgtctgttgaatttct	Protospacer
*************..************

2. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to position: 958875-958901, mismatch: 2, identity: 0.926

ccaacttgctttgcttgttgaatttct	CRISPR spacer
ccaacttgctttgtctgttgaatttct	Protospacer
*************..************

3. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to position: 1194556-1194582, mismatch: 2, identity: 0.926

ccaacttgctttgcttgttgaatttct	CRISPR spacer
ccaacttgctctgcctgttgaatttct	Protospacer
**********.***.************

4. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to position: 2090200-2090226, mismatch: 2, identity: 0.926

ccaacttgctttgcttgttgaatttct	CRISPR spacer
ccaacctgctttgcctgttgaatttct	Protospacer
*****.********.************

5. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to position: 2305138-2305164, mismatch: 2, identity: 0.926

ccaacttgctttgcttgttgaatttct	CRISPR spacer
ccaacttgctttgtctgttgaatttct	Protospacer
*************..************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	MN694027	Marine virus AFVG_250M455, complete genome	27746-27772	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	MN694088	Marine virus AFVG_250M454, complete genome	24349-24375	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	MN694007	Marine virus AFVG_250M456, complete genome	24394-24420	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP034911	Ensifer alkalisoli strain YIC4027 plasmid unnamed, complete sequence	337057-337083	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP040783	Bacillus thuringiensis strain HM-311 plasmid p1, complete sequence	80159-80185	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NC_020394	Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-233, complete sequence	137021-137047	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP014283	Bacillus thuringiensis strain Bt185 plasmid pBT1850636, complete sequence	280870-280896	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP031069	Bacillus sp. JAS24-2 plasmid pl626, complete sequence	622506-622532	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP020005	Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed3, complete sequence	75068-75094	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP022446	Bacillus cereus C1L plasmid pC1L1, complete sequence	414799-414825	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP032614	Bacillus thuringiensis strain QZL38 plasmid p.1, complete sequence	454459-454485	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP007513	Bacillus bombysepticus plasmid pBb, complete genome	88318-88344	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_AP014865	Bacillus thuringiensis serovar tolworthi strain Pasteur Institute Standard strain plasmid pKK1, complete sequence	382031-382057	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP053952	Bacillus cereus strain FDAARGOS_798 plasmid unnamed1, complete sequence	247116-247142	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	CP046512	Bacillus cereus strain JHU plasmid p1, complete sequence	459206-459232	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP023246	Bacillus cereus strain HBL-AI plasmid unnamed1, complete sequence	513161-513187	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP011154	Bacillus cereus strain CMCC P0011 plasmid pRML05, complete sequence	310868-310894	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	CP020755	Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence	374432-374458	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP021062	Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence	5344-5370	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP053657	Bacillus cereus strain CTMA_1571 plasmid p.1, complete sequence	330728-330754	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP053949	Bacillus cereus strain FDAARGOS_799 plasmid unnamed1, complete sequence	377266-377292	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP044979	Bacillus thuringiensis strain BT62 plasmid pBT62A, complete sequence	497400-497426	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP042875	Bacillus cereus strain 09 plasmid unnamed1, complete sequence	258660-258686	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP011152	Bacillus cereus strain CMCC P0021 plasmid pRML04, complete sequence	236021-236047	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP040345	Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence	500605-500631	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP045607	Bacillus cereus strain SB1 plasmid p1, complete sequence	543659-543685	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP050184	Bacillus thuringiensis strain HER1410 plasmid pLUSID1, complete sequence	314628-314654	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	NZ_CP016589	Bacillus thuringiensis strain KNU-07 plasmid pBTKNU07-01, complete sequence	124810-124836	5	0.815
NZ_AP019721_1	1.1\|2365449\|27\|NZ_AP019721\|CRISPRCasFinder	2365449-2365475	27	MN693811	Marine virus AFVG_250M463, complete genome	40836-40862	6	0.778

1. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to MN694027 (Marine virus AFVG_250M455, complete genome) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
ctaagttgctttgcttgttgaattaaa	Protospacer
*.** *******************

2. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to MN694088 (Marine virus AFVG_250M454, complete genome) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
ctaagttgctttgcttgttgaattaaa	Protospacer
*.** *******************

3. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to MN694007 (Marine virus AFVG_250M456, complete genome) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
ctaagttgctttgcttgttgaattaaa	Protospacer
*.** *******************

4. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP034911 (Ensifer alkalisoli strain YIC4027 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cttgcttgctttgccttttgaatttct	Protospacer
*. .**********.* **********

5. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP040783 (Bacillus thuringiensis strain HM-311 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

6. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NC_020394 (Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-233, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

7. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP014283 (Bacillus thuringiensis strain Bt185 plasmid pBT1850636, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

8. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP031069 (Bacillus sp. JAS24-2 plasmid pl626, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

9. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP020005 (Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

10. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP022446 (Bacillus cereus C1L plasmid pC1L1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

11. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP032614 (Bacillus thuringiensis strain QZL38 plasmid p.1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

12. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP007513 (Bacillus bombysepticus plasmid pBb, complete genome) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

13. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_AP014865 (Bacillus thuringiensis serovar tolworthi strain Pasteur Institute Standard strain plasmid pKK1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

14. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP053952 (Bacillus cereus strain FDAARGOS_798 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

15. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to CP046512 (Bacillus cereus strain JHU plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

16. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP023246 (Bacillus cereus strain HBL-AI plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

17. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP011154 (Bacillus cereus strain CMCC P0011 plasmid pRML05, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

18. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to CP020755 (Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

19. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP021062 (Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

20. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP053657 (Bacillus cereus strain CTMA_1571 plasmid p.1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

21. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP053949 (Bacillus cereus strain FDAARGOS_799 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

22. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP044979 (Bacillus thuringiensis strain BT62 plasmid pBT62A, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

23. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP042875 (Bacillus cereus strain 09 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

24. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP011152 (Bacillus cereus strain CMCC P0021 plasmid pRML04, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

25. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP040345 (Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cgctcttgttttgcttgttgtatttct	Protospacer
*   ****.*********** ******

26. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP045607 (Bacillus cereus strain SB1 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

27. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP050184 (Bacillus thuringiensis strain HER1410 plasmid pLUSID1, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

28. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to NZ_CP016589 (Bacillus thuringiensis strain KNU-07 plasmid pBTKNU07-01, complete sequence) position: , mismatch: 5, identity: 0.815

ccaacttgctttgcttgttgaatttct	CRISPR spacer
cggtcttgttttgcttgttgtatttct	Protospacer
* . ****.*********** ******

29. spacer 1.1|2365449|27|NZ_AP019721|CRISPRCasFinder matches to MN693811 (Marine virus AFVG_250M463, complete genome) position: , mismatch: 6, identity: 0.778

ccaacttgctttgcttgttgaatttct	CRISPR spacer
tgattctgctttgcttgttgaatatct	Protospacer
. * ..***************** ***

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

49525 : 81469

Staphylococcus_phage(55.56%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_134943505.1\|49525_50200_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.3e-126	98.7
WP_164071529.1\|50227_50680_-	signal peptidase II	NA	NA	NA	NA
WP_057504659.1\|50839_51241_+	winged helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	1.9e-21	45.6
WP_057504658.1\|51494_52262_+	ZIP family metal transporter	NA	NA	NA	NA
WP_002485759.1\|52518_54927_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	8.1e-256	64.9
WP_142191172.1\|54907_56602_-\|transposase	IS1182-like element ISSep1 family transposase	A0ZS58	Staphylococcus_virus	1.5e-243	77.6
WP_049374229.1\|57022_58444_+	dihydrolipoyl dehydrogenase	NA	NA	NA	NA
WP_057504655.1\|58671_59334_+	CadD family cadmium resistance transporter	NA	NA	NA	NA
WP_001105987.1\|59841_60516_-\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	6.8e-128	99.6
WP_000163428.1\|60798_62145_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_000425271.1\|62444_62852_+	Hg(II)-responsive transcriptional regulator MerR	NA	NA	NA	NA
WP_000746201.1\|62868_63222_+	TlpA family protein disulfide reductase	NA	NA	NA	NA
WP_000010351.1\|63218_63899_+	cytochrome c biosynthesis protein	NA	NA	NA	NA
WP_000968575.1\|64033_64372_+	hypothetical protein	NA	NA	NA	NA
WP_057504652.1\|64429_66073_+	mercury(II) reductase	A0A2K5B2C5	Erysipelothrix_phage	1.7e-50	29.4
WP_000790334.1\|66154_66805_+	organomercurial lyase MerB	NA	NA	NA	NA
WP_000377077.1\|66999_67515_-	hypothetical protein	NA	NA	NA	NA
WP_001802813.1\|67984_68266_+	hypothetical protein	NA	NA	NA	NA
WP_002409346.1\|68331_69006_-\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	3.4e-127	99.1
WP_001053439.1\|69205_69835_+	hypothetical protein	NA	NA	NA	NA
WP_000931963.1\|69849_70092_+	hypothetical protein	NA	NA	NA	NA
WP_000832687.1\|70490_71342_+\|transposase	IS3 family transposase	A0A0N9SIX5	Staphylococcus_phage	1.4e-69	95.7
WP_000036756.1\|71441_72371_-	carbamate kinase	NA	NA	NA	NA
WP_000793596.1\|72390_73389_-	ornithine carbamoyltransferase	NA	NA	NA	NA
WP_000272781.1\|73426_74116_-	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_000344142.1\|74157_75579_-	arginine-ornithine antiporter	NA	NA	NA	NA
WP_000249804.1\|75664_76900_-	arginine deiminase	NA	NA	NA	NA
WP_000711815.1\|77168_77615_-	ArgR family transcriptional regulator	NA	NA	NA	NA
WP_078147993.1\|78557_78869_+	DUF3387 domain-containing protein	NA	NA	NA	NA
WP_000475804.1\|79139_79571_-	universal stress protein	NA	NA	NA	NA
WP_000916431.1\|80452_80779_-	hypothetical protein	NA	NA	NA	NA
WP_001106065.1\|80794_81469_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	9.6e-122	95.5

DBSCAN-SWA_2

1016727 : 1064953

Staphylococcus_phage(81.82%)

transposase,tRNA,integrase

attL 1006857:1006873|attR 1049628:1049644

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1006857:1006873	attL	NA	NA	NA	NA
WP_002456422.1\|1016727_1017222_-\|integrase	site-specific integrase	B7T092	Staphylococcus_virus	3.8e-67	76.1
WP_002456423.1\|1017380_1017593_+	hypothetical protein	A0A2H4JCA1	uncultured_Caudovirales_phage	7.3e-20	72.9
WP_002456424.1\|1017972_1018707_-	hypothetical protein	NA	NA	NA	NA
WP_049387519.1\|1019233_1019521_-	hypothetical protein	A0A2H4JGN1	uncultured_Caudovirales_phage	1.6e-17	50.0
WP_002456427.1\|1019682_1020348_-	Ltp family lipoprotein	A0A2H4J5B8	uncultured_Caudovirales_phage	7.0e-08	41.8
WP_002456429.1\|1021598_1023023_+	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	6.6e-173	63.9
WP_001829851.1\|1023012_1024014_+	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	6.9e-92	50.2
WP_002457867.1\|1024010_1024259_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	6.5e-36	83.1
WP_002456430.1\|1024329_1024797_+	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	5.5e-44	57.4
WP_002456431.1\|1024783_1025569_+	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	2.0e-99	71.3
WP_002489635.1\|1025799_1027392_-	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	2.1e-268	83.4
WP_001829830.1\|1027761_1028961_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	4.1e-192	85.4
WP_002474706.1\|1029063_1029972_+	hypothetical protein	A0A2H4PQQ8	Staphylococcus_phage	1.8e-102	80.6
WP_001829832.1\|1030152_1030989_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.0e-120	73.3
WP_162154154.1\|1031291_1031429_+	hypothetical protein	A0A146ICT8	Staphylococcus_phage	4.0e-11	76.7
WP_141651809.1\|1031658_1032837_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	7.4e-61	37.2
WP_001830729.1\|1033315_1033669_-	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	8.5e-05	32.5
WP_001830726.1\|1033665_1034031_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	4.1e-34	57.0
WP_002446728.1\|1034069_1034378_-	hypothetical protein	NA	NA	NA	NA
WP_001830731.1\|1034654_1035368_+	transaldolase	M1PR54	Cyanophage	4.1e-22	37.4
WP_002485267.1\|1035507_1035951_+	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	5.3e-20	43.5
WP_001830734.1\|1035937_1036381_-	competence protein ComK	NA	NA	NA	NA
WP_001830724.1\|1036386_1036866_-	sigma-70 family RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	2.7e-25	42.3
WP_002456441.1\|1037073_1037289_+	hypothetical protein	NA	NA	NA	NA
WP_001830727.1\|1037666_1038518_+	glucosaminidase domain-containing protein	A0A1J0MFB0	Staphylococcus_phage	1.0e-32	35.6
WP_002484471.1\|1038865_1040350_+	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	2.5e-13	65.6
WP_002495598.1\|1040786_1041830_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	8.9e-135	66.8
WP_002467848.1\|1041836_1042469_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.1e-87	77.6
WP_002456445.1\|1042481_1043663_+	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	2.5e-178	76.1
WP_002456446.1\|1043675_1044137_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.2e-59	84.2
WP_001832688.1\|1044393_1045395_-	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	1.3e-130	69.4
WP_001830886.1\|1045637_1046465_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_001830809.1\|1046954_1047356_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_001830894.1\|1047592_1048156_-	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	1.9e-67	66.5
WP_001830802.1\|1048152_1049106_-	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	3.3e-67	84.7
WP_001830884.1\|1049212_1050427_+	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	4.6e-183	83.7
1049628:1049644	attR	NA	NA	NA	NA
WP_002493961.1\|1050718_1053133_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	87.4
WP_001830891.1\|1053158_1053470_+	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	4.1e-35	71.8
WP_001832672.1\|1053874_1064953_+	YSIRK signal domain/LPXTG anchor domain surface protein	A0A2H4PQU6	Staphylococcus_phage	7.8e-27	25.7

DBSCAN-SWA_3

1774006 : 1782476

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001831672.1\|1774006_1774573_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.1e-29	40.0
WP_001831685.1\|1774572_1775604_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	2.1e-64	43.4
WP_002485328.1\|1775596_1777081_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	7.2e-45	31.9
WP_002467589.1\|1777059_1779249_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.1e-139	40.4
WP_001831727.1\|1779241_1779913_-	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_001831728.1\|1779914_1780175_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_001831723.1\|1780174_1780879_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	H8ZMN3	Synechococcus_phage	1.6e-47	42.5
WP_002486052.1\|1780879_1782007_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_002486053.1\|1781993_1782476_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.6e-20	42.7

DBSCAN-SWA_4

2015855 : 2026289

uncultured_Caudovirales_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001829596.1\|2015855_2016635_-	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	5.1e-18	33.6
WP_002438903.1\|2016631_2017591_-	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	4.1e-17	100.0
WP_001829651.1\|2017574_2018549_-	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	1.0e-164	99.4
WP_002456931.1\|2018564_2018828_-	hypothetical protein	A0A2H4IYB4	uncultured_Caudovirales_phage	5.5e-17	100.0
WP_001829597.1\|2018802_2019771_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	3.9e-185	100.0
WP_001829582.1\|2019889_2021995_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	100.0
WP_001829589.1\|2021957_2022356_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	2.0e-71	100.0
WP_002468673.1\|2023116_2023986_+	DMT family transporter	NA	NA	NA	NA
WP_001832596.1\|2023999_2024500_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	1.1e-50	70.1
WP_001832607.1\|2024783_2026289_+	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	5.5e-61	34.0

DBSCAN-SWA_5

2046152 : 2056687

Staphylococcus_phage(22.22%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001830323.1\|2046152_2047304_-	anthranilate synthase component I family protein	A0A0B5J984	Pandoravirus	7.5e-26	39.6
WP_001830349.1\|2047293_2047881_-	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.4e-38	42.9
WP_057504650.1\|2048177_2048849_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	1.2e-63	55.2
WP_001830341.1\|2048853_2049273_+	6-carboxytetrahydropterin synthase QueD	NA	NA	NA	NA
WP_001830330.1\|2049273_2049987_+	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	1.6e-55	44.8
WP_001830331.1\|2050088_2050688_+	hypothetical protein	NA	NA	NA	NA
WP_162152262.1\|2051055_2051193_+	hypothetical protein	A0A146ICT8	Staphylococcus_phage	1.1e-11	79.1
WP_001830329.1\|2051788_2052226_+	DM13 domain-containing protein	NA	NA	NA	NA
WP_001830332.1\|2052276_2052750_+	DoxX family protein	NA	NA	NA	NA
WP_001830352.1\|2052724_2053414_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.4e-34	35.2
WP_025987135.1\|2053416_2054469_+	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	2.0e-17	30.6
WP_057504638.1\|2054538_2055645_-	glycosyltransferase family 2 protein	A8CG95	Salmonella_phage	9.1e-61	42.9
WP_054828590.1\|2055847_2056687_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.2e-60	43.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage