CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP041202	Vibrio parahaemolyticus strain Vb0624 chromosome 1, complete sequence	0 crisprs	cas3,DinG,csa3,DEDDh,csx1,WYL	0	0	4	0
NZ_CP041201	Vibrio parahaemolyticus strain Vb0624 chromosome 2, complete sequence	3 crisprs	cas3,csa3,WYL,DEDDh	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

747186 : 753888

Staphylococcus_phage(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005483011.1\|747186_748326_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.3e-62	41.7
WP_141179879.1\|748343_749594_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	2.3e-97	47.7
WP_005482986.1\|749721_750171_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_141179880.1\|750178_751303_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	5.2e-48	36.0
WP_005483039.1\|751315_751969_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.6e-33	37.5
WP_025521214.1\|752138_753248_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.5e-63	39.6
WP_005440184.1\|753417_753888_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.7e-32	49.3

DBSCAN-SWA_2

1032929 : 1057964

Vibrio_phage(46.15%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_141179923.1\|1032929_1033838_-	hypothetical protein	G8CLB2	Synechococcus_phage	1.8e-35	34.1
WP_065297113.1\|1033827_1034274_-	hypothetical protein	NA	NA	NA	NA
WP_141179924.1\|1034273_1034705_-	DUF1320 family protein	A0A0M3VI88	Ralstonia_phage	2.6e-19	40.9
WP_141179925.1\|1035349_1036243_-	hypothetical protein	L7P7Y9	Pseudomonas_phage	9.2e-72	49.3
WP_141179926.1\|1036289_1036682_-	hypothetical protein	NA	NA	NA	NA
WP_141179927.1\|1036682_1037840_-	hypothetical protein	A0A0C4UQU6	Shigella_phage	1.2e-71	44.7
WP_141179928.1\|1037887_1038601_-	hypothetical protein	A0A1L5C2A8	Pseudoalteromonas_phage	1.4e-17	32.7
WP_141179929.1\|1038769_1038958_-	hypothetical protein	NA	NA	NA	NA
WP_141179930.1\|1039203_1039662_-	phage virion morphogenesis protein	Q5ZQY1	Pseudomonas_phage	2.7e-19	39.1
WP_141179931.1\|1039661_1039859_-	hypothetical protein	NA	NA	NA	NA
WP_141179932.1\|1039868_1041272_-	F protein	A0A2H4IYU7	uncultured_Caudovirales_phage	5.9e-65	47.9
WP_141179933.1\|1041386_1042961_-	DUF935 family protein	C9DGN6	Escherichia_phage	5.5e-128	48.8
WP_141179934.1\|1042981_1044532_-	hypothetical protein	M1NVQ0	Vibrio_phage	7.0e-184	64.4
WP_141179935.1\|1044531_1045113_-	DUF3486 family protein	A0A2I7S9D1	Vibrio_phage	2.1e-32	43.4
WP_065297126.1\|1045270_1045561_-	hypothetical protein	A0A2I7S9D8	Vibrio_phage	1.4e-21	54.3
WP_081280737.1\|1045547_1045874_-	DUF2730 family protein	A0A2I7S9E2	Vibrio_phage	1.4e-09	37.2
WP_141179936.1\|1045870_1046089_-	TraR/DksA family transcriptional regulator	NA	NA	NA	NA
WP_141179937.1\|1046085_1046592_-	hypothetical protein	A0A2I7S9B5	Vibrio_phage	1.8e-24	44.2
WP_141179938.1\|1046847_1047294_-	hypothetical protein	M4M9N1	Vibrio_phage	5.7e-46	60.0
WP_141179939.1\|1047439_1047841_-	transcriptional regulator	A0A0C4UR27	Shigella_phage	1.1e-19	40.2
WP_141179940.1\|1047988_1048285_+	hypothetical protein	NA	NA	NA	NA
WP_141179941.1\|1048321_1048636_-	hypothetical protein	NA	NA	NA	NA
WP_141179942.1\|1048651_1048918_-	hypothetical protein	NA	NA	NA	NA
WP_141179943.1\|1048926_1049466_-	hypothetical protein	A0A2P9JZH6	Alteromonadaceae_phage	2.4e-27	45.8
WP_141179944.1\|1049476_1049797_-	hypothetical protein	NA	NA	NA	NA
WP_141179945.1\|1049793_1050372_-	DUF1018 domain-containing protein	A0A0C4UQU3	Shigella_phage	7.6e-27	38.0
WP_141179946.1\|1050568_1051015_-	hypothetical protein	M4MHH2	Vibrio_phage	2.9e-34	54.0
WP_141179947.1\|1051014_1051290_-	hypothetical protein	R9TR78	Vibrio_phage	3.1e-26	54.9
WP_115206381.1\|1051359_1051554_-	hypothetical protein	A0A2I7S9A9	Vibrio_phage	1.9e-06	39.0
WP_122069545.1\|1051550_1051751_-	ANR family transcriptional regulator	NA	NA	NA	NA
WP_122069547.1\|1051762_1052386_-	DUF3164 family protein	A0A2H4IYN0	uncultured_Caudovirales_phage	5.9e-41	43.3
WP_122069549.1\|1052373_1052571_-	hypothetical protein	NA	NA	NA	NA
WP_141179948.1\|1052555_1052828_-	hypothetical protein	NA	NA	NA	NA
WP_141179949.1\|1052889_1053243_-	hypothetical protein	NA	NA	NA	NA
WP_141179950.1\|1053229_1054180_-	AAA family ATPase	M4M9P4	Vibrio_phage	7.5e-80	49.7
WP_141179951.1\|1054197_1056189_-	DDE endonuclease	M4M9R2	Vibrio_phage	4.4e-199	53.7
WP_141179952.1\|1056185_1056668_-	hypothetical protein	Q6QID6	Burkholderia_phage	7.0e-42	49.7
WP_141179953.1\|1056791_1057043_-	transcriptional regulator	A0A0C4UQU0	Shigella_phage	1.3e-20	66.7
WP_141180535.1\|1057244_1057964_+	helix-turn-helix transcriptional regulator	A0A2I7S9A5	Vibrio_phage	4.0e-57	70.0

DBSCAN-SWA_3

2868755 : 2885939

Klosneuvirus(20.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005455546.1\|2868755_2871338_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	1.0e-78	37.9
WP_141180414.1\|2871480_2871948_-	recombination regulator RecX	NA	NA	NA	NA
WP_005478550.1\|2872071_2873115_-	recombinase RecA	A0A2D1GPX2	Mycobacterium_phage	8.1e-112	60.7
WP_017449151.1\|2873315_2873798_-	nicotinamide-nucleotide amidase	B5TK85	Pseudomonas_phage	1.7e-27	48.7
WP_141180415.1\|2873882_2876444_+	DNA mismatch repair protein MutS	A0A1V0SJ67	Klosneuvirus	2.9e-33	24.8
WP_005455560.1\|2877593_2878517_-	peptidoglycan DD-metalloendopeptidase family protein	D7RWE0	Brochothrix_phage	4.1e-06	35.2
WP_005455562.1\|2878531_2879158_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	1.3e-35	52.1
WP_140166594.1\|2879157_2879934_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	8.6e-66	52.4
WP_140166593.1\|2879933_2880977_-\|tRNA	tRNA pseudouridine(13) synthase TruD	NA	NA	NA	NA
WP_005380896.1\|2881023_2881500_-	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	NA	NA	NA	NA
WP_047734140.1\|2881517_2882222_-	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	A0A2H4UTB4	Bodo_saltans_virus	1.0e-04	22.2
WP_005455577.1\|2882223_2882505_-	cell division protein FtsB	NA	NA	NA	NA
WP_005455579.1\|2882918_2884220_-	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	4.2e-134	59.2
WP_141180416.1\|2884298_2885939_-	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	7.2e-155	52.4

DBSCAN-SWA_4

3025006 : 3086397

Salmonella_phage(50.0%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023624214.1\|3025006_3026350_-\|protease	metalloprotease PmbA	NA	NA	NA	NA
WP_005457057.1\|3026460_3026988_+	ribosome-associated protein	NA	NA	NA	NA
WP_141180443.1\|3027060_3028023_-	D-2-hydroxyacid dehydrogenase	M1HMI7	Paramecium_bursaria_Chlorella_virus	3.3e-27	29.9
WP_140281998.1\|3028057_3028810_-\|tRNA	bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA	NA	NA	NA	NA
WP_005478846.1\|3028856_3028973_-	hypothetical protein	NA	NA	NA	NA
WP_141180444.1\|3029137_3030403_+	divalent metal cation transporter	NA	NA	NA	NA
WP_141180445.1\|3030472_3033382_-	RNA polymerase-associated protein RapA	A0A1B1IUI1	uncultured_Mediterranean_phage	2.9e-21	36.1
WP_005461836.1\|3033939_3035316_+	PhoH family protein	A0A2I7SAD7	Vibrio_phage	1.3e-104	44.4
WP_020835343.1\|3035386_3036832_-\|protease	metalloprotease TldD	NA	NA	NA	NA
WP_025533072.1\|3036843_3037665_-	carbon-nitrogen hydrolase family protein	NA	NA	NA	NA
WP_141180446.1\|3037699_3041578_-	TIGR02099 family protein	NA	NA	NA	NA
WP_005461826.1\|3041589_3043059_-	ribonuclease G	NA	NA	NA	NA
WP_141180447.1\|3043077_3043647_-	septum formation inhibitor Maf	NA	NA	NA	NA
WP_005461823.1\|3043651_3044140_-	rod shape-determining protein MreD	NA	NA	NA	NA
WP_005461822.1\|3044129_3045026_-	rod shape-determining protein MreC	NA	NA	NA	NA
WP_005381144.1\|3045163_3046207_-	rod shape-determining protein	F2Y0P3	Organic_Lake_phycodnavirus	2.7e-06	20.3
WP_141180448.1\|3046358_3050930_-	hypothetical protein	NA	NA	NA	NA
WP_025579232.1\|3050934_3051357_-	MSHA biogenesis protein MshP	NA	NA	NA	NA
WP_140289726.1\|3051346_3052135_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_025579235.1\|3052134_3052695_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_025579237.1\|3052691_3053159_-	type II secretion system protein	NA	NA	NA	NA
WP_141180572.1\|3053274_3053508_-	MSHA biogenesis protein MshA	NA	NA	NA	NA
WP_005497282.1\|3053569_3054031_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_025592230.1\|3054325_3054787_-	MSHA biogenesis protein MshF	NA	NA	NA	NA
WP_021484749.1\|3054790_3056014_-	type II secretion system F family protein	NA	NA	NA	NA
WP_020835334.1\|3056022_3057747_-	type II/IV secretion system protein	NA	NA	NA	NA
WP_031791808.1\|3057743_3058832_-	MSHA biogenesis protein MshN	NA	NA	NA	NA
WP_005456312.1\|3058816_3059662_-	AAA family ATPase	NA	NA	NA	NA
WP_005456314.1\|3059705_3061349_-	pilus (MSHA type) biogenesis protein MshL	NA	NA	NA	NA
WP_005481006.1\|3061369_3061699_-	MSHA biogenesis protein MshK	NA	NA	NA	NA
WP_005497276.1\|3061691_3062342_-	MSHA biogenesis protein MshJ	NA	NA	NA	NA
WP_025611168.1\|3062338_3063784_-	MSHA biogenesis protein MshI	NA	NA	NA	NA
WP_011106082.1\|3063795_3065805_-	RNase E specificity factor CsrD	NA	NA	NA	NA
WP_141179716.1\|3066005_3067199_-\|transposase	ISL3 family transposase	A9YX10	Burkholderia_phage	1.1e-101	48.7
WP_141180449.1\|3067606_3068569_+\|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_141180450.1\|3068612_3071768_-	DEAD/DEAH box helicase family protein	NA	NA	NA	NA
WP_141180451.1\|3071838_3072423_-	DUF2971 domain-containing protein	NA	NA	NA	NA
WP_141180573.1\|3072419_3073763_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_141180452.1\|3073777_3075751_-	N-6 DNA methylase	A0A220A2U5	Liberibacter_phage	6.6e-30	24.9
WP_001138014.1\|3076176_3079143_-\|transposase	Tn3-like element TnAs1 family transposase	A0A1B0V7H9	Salmonella_phage	0.0e+00	100.0
WP_001161490.1\|3079146_3079707_-	recombinase family protein	A0A1B0V7I5	Salmonella_phage	1.1e-59	100.0
WP_013362812.1\|3081774_3082743_-\|transposase	IS5-like element IS903B family transposase	A0A1B0VFY5	Salmonella_phage	1.6e-186	100.0
WP_001617865.1\|3082777_3083653_-	class A extended-spectrum beta-lactamase CTX-M-14	A0A1B0VBP7	Salmonella_phage	6.1e-153	99.6
WP_000608644.1\|3083902_3085165_-\|transposase	IS1380-like element ISEc9 family transposase	A0A1B0VDR3	Salmonella_phage	1.3e-39	100.0
WP_014342102.1\|3085365_3086397_+	methyl-accepting chemotaxis protein	A0A1B0VAH3	Salmonella_phage	1.2e-51	100.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP041201

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP041201_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP041201_1

200004-200219

Orphan

Consensus_repeat	Method
CCACGCCCTGATTATCAGGCTGTGG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP041201_1

>merge|NZ_CP041201|1|200004-200219|CRISPRCasFinder
AGAGGGCCTGATATTCAGGCGCTGGGTTACTTTTTGACCATCCACGGCCTTATTATCAGGCTGTGGATTGCAAGTGTCTGTAATTCCTAAATTATCACTATCAAAAACCACGCCCTGATTATCAGGCTGTGGGATATTTTCATCATTACCACGGCCTGATATATCGTCTCCGGTTTCTAGGCCCTGGTTTTCCACGCCCTGATTATCAGGCTGTGG

>NZ_CP041201|1|1|200004-200219|CRISPRCasFinder
AGAGGGCCTGATATTCAGGCGCTGG	GTTACTTTTTGACCAT
CCACGGCCTTATTATCAGGCTGTGG	ATTGCAAGTGTCTGTAATTCCTAAATTATCACTATCAAAAA
CCACGCCCTGATTATCAGGCTGTGG	GATATTTTCATCATTACCACGGCCTGATATATCGTCTCCGGTTTCTAGGCCCTGGTTTT
CCACGCCCTGATTATCAGGCTGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP041201.1\|WP_128413544.1\|205154_205418_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_128413547.1\|207862_208174_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_141179267.1\|205417_207139_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_128413539.1\|199218_199749_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182057
NZ_CP041201.1\|WP_140330020.1\|204126_204624_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368503
NZ_CP041201.1\|WP_088581846.1\|200946_201258_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP041201.1\|WP_088581854.1\|197586_197769_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_128413541.1\|200529_200796_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374243
NZ_CP041201.1\|WP_088581843.1\|204726_204927_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225848
NZ_CP041201.1\|WP_141179261.1\|196540_196951_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_141179263.1\|197366_197582_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_141179266.1\|201394_204130_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_088581839.1\|207650_207860_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_088581852.1\|197985_198231_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_128413533.1\|195871_196066_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_141179264.1\|197765_197993_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_128413538.1\|198833_199226_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_141179262.1\|197118_197367_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_140330018.1\|207156_207624_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_141179265.1\|198236_198578_-\|hypothetical-protein	unknown	unknown	unknown

>NZ_CP041201.1|WP_128413539.1|199218_199749_-|hypothetical-protein
MASEWVLSGIDDVQQIAGYVCDYFELSEYENPPPLRVQITKKNNGTLPMLKLWRMWMADIAKFQVRRGATIPILAPQTNANGVIEWKAIGERPYNENDAHEAYTYLLLGCDERGVRYSWAVHTDNYEGRKVASLSRKLHAMQKFHQFCIENSIPIRIPERSEYQELQDKQNGIKHD
>NZ_CP041201.1|WP_128413538.1|198833_199226_-|hypothetical-protein
MINLRSKKFHGHFEPTAKQEKEWLQRITLYAQQHGSFPQRSQGNFDRHHVKGRTFAHKKVHLGRWLVIPVEEEFHHVMSNNPLNVTHYKSRYEEAFGTQIEQFLEMCEQIKNEDGFLPMADQVIIAAKSL
>NZ_CP041201.1|WP_141179265.1|198236_198578_-|hypothetical-protein
MGNYIPKYYPEVWYGGNRYMESDWDFIVKHLACLSEEKQKFVSDVYENIYRRHFNKKNYRDARLFANKYLQDYTRDNWDVNPQFENVKNPKQERINQVMQAQKDSKMKINLDR
>NZ_CP041201.1|WP_088581852.1|197985_198231_-|hypothetical-protein
MACSSANPLGKIRRYLDLTQVKADEKCGLKPGAFVKRESGENLYWSTFVSTLNAFELDSYLVIECPNGDKLKIKLTENQNG
>NZ_CP041201.1|WP_141179264.1|197765_197993_-|hypothetical-protein
MAKIIIEIERVQGPMFDASEISMPMEVKISVKGSKDRHDLIPTAVAHKLAACYSESISLGISSAFKSVIIEAAKK
>NZ_CP041201.1|WP_088581854.1|197586_197769_-|hypothetical-protein
MSDINGFNDWKHKKEKQDNGFALPNTSKLKPNLKKLRTRRSIEAIAEESKLNKEFNYLEK
>NZ_CP041201.1|WP_141179263.1|197366_197582_-|hypothetical-protein
MKSCEMPEVTLNGIELQSNNVTANEIETDITFSSVGDYVNAFKEMAEKISDETLIKMLADRDQAYISEDYQ
>NZ_CP041201.1|WP_141179262.1|197118_197367_-|hypothetical-protein
MANKGIKTLAKFTALRLAAVQLNHQCSAHDTFYEFDGVTDELKNEINKEISKIVNSLEVRAKKLSNSTPIGLIDLVDISQSV
>NZ_CP041201.1|WP_141179261.1|196540_196951_-|hypothetical-protein
MSELKNHYGENVGWFCYEASLIDADFKHDDLIPDVLEIICDNGGSIDVDVRNLFESAHVVIEEQQDKIKELKENDKRSFFSGLAVALQSVAMFDHATMAEEIINGLGSEKEAFYSYLKSEGGVDFETLAYLKSNGL
>NZ_CP041201.1|WP_128413533.1|195871_196066_-|hypothetical-protein
MKKYSEISELPMAIKEIDRLNKINSELMNAINQTIGFVESTNGDEESIRLLRSAIIKVQSHAKQ
>NZ_CP041201.1|WP_128413541.1|200529_200796_-|hypothetical-protein
MGNKVDKKNALLNAIDAVGGKKALAESIGCSVRNINLMLSGDGATSKLALKISMASGVHVCELCPEFYPPEIFSEMSIPGRNSEHANN
>NZ_CP041201.1|WP_088581846.1|200946_201258_+|helix-turn-helix-transcriptional-regulator
MSGYGERMKKLMDERGMSTEQLAARVGLSQRAINMIISGETTRTRKSPEIAKALGTTHEYLMYGSNAKGSDATWIDELKALNLGKEQIDSLLNVAKMMSKVIK
>NZ_CP041201.1|WP_141179266.1|201394_204130_+|hypothetical-protein
MSKVFKATCKSFKGQHPAGLVIHEVYVTDKFAKDAVEKAKIELKFWDPEHFDKYQAPKVVAVKENAETELETYLLKKENHGQEEINEQPGEAELPTNTTNLFDEPSATVAEFAIAYPYVVRVAIALSKGSFLSSYSILNSEDNAVAVGFISSFNPRSFKEIDNAISFAIGNAIEAINKHMGNVFIDADLESSIKMLKNYSSDAESEFIDNYVDDIDLQSAIITEVVAEVEKLTTSNKTDEISIIADAVICHRDYKNCADPHEPEEFIGQVKSNFKEISDEYGELPGKSIAEHIQSMSSVRDLYNLGPCEEIAGLYITHQSNELSEAAKDALDKTIATSQENADKDWPKGEPLAYDSSNEWQRLAFTILSKTNEAGEPTPQQYKEIAAKLCGVFAERGLELMSGEFYSEVATQLITNAINADSVISTLFNLRELRKLISEITESPSSNESESKHGLKPNHNTENEHECFIAEILSRLQTDGANFLTSEQFEEAGEKFNIILDEANKTYGNEFDRVSTLENIRNIDWDNISEATKVFLNIRSLRACFRENVEVIKTTETASNEVEKPEVATNEASSGNNEQINGNSEPKQQESLPEEAKQVVEPGNAVPASNDDTVSDNGDGNGEAVKQVDVDALESKWSNNANMRIWAKVHKTDSEYTKRDHNGRNSISTQYRIMKMTEAFGPAGFGWGYKVLREWTTQGAPIVVNNEPTGMHEIIHHCEVEIWYKHQGQKSEPITHYGDTRQFYYSRGWQDKPGYFVNDDEVHKKSLSDALGKAMSMLGVCADVYLGEHDDAHIETLNHNLVEAAKKVRHLEEEEKIRKEVNEKVAAIVDEMQEEKTKVGVNTLRAKALHVISGLPDISDEQKRRKSSVIQQLQVRYNQRLNEVVEEQERKKQEKAAKAAANKEAAEKEEA
>NZ_CP041201.1|WP_140330020.1|204126_204624_+|hypothetical-protein
MIMANIFELAADRKEMFKILEENDYDISFIQDTLDGDGFDEKINDWLRVIANAEGTAKMLKAEKEAIAARQTQFENQAKNMKAALHQVMKNLNYQTYKVPLGTLSRSEIKPAIKFDESNLSESYIIIDTVKTPDKQKIESDMNAGIEVPGAYFEMQPERFSIRKK
>NZ_CP041201.1|WP_088581843.1|204726_204927_+|hypothetical-protein
MERFLTAKDIRDLLSIAPATFNNMVKDGRFPEPDFGGGMGAARRWKESTYNQWCEQGCSNGNKIAS
>NZ_CP041201.1|WP_128413544.1|205154_205418_+|hypothetical-protein
MSTLPMETNDTNDWKLYPNSSNFSGMVQNGCDYPIYLYVTASGATPAEPNGVVLKGGIGESLPVSIPDTEELHFKPVTKGPVKLRLA
>NZ_CP041201.1|WP_141179267.1|205417_207139_+|hypothetical-protein
MSGNFLKPLDIMDNGNFGLITDKPESPSIRVSSVTINETLNLLLPGDNGTLTATVKYSDNSEITSTDDPSIVGWESSDESILTVNSNGGYIANGSGDATITARSSESPTVFDSLNITVVGSFDEFNFGIFDKAESDGGTLVYDSGYIEKQPWLTINEYENNLSDLGAVLIAQDGDVVNGGAIIFSSGGERAIVALYKKVTDGYELVVESDVLSANSGETQFHIVDFSTEETPLEPGESYFFCVINSSTDETGAAVVSSIGDLSNKYPLVTEAAAPPALLDSAIDSSSTWSRAAVFKLQRPSNDWHILIASRIVTGDVNGFTSTKGSIRPTNVNGATMVALEANVAGGYIRATINTDAIGEPFALVVIEYEGNVYSMPYYSGFRYELHDAAKTQLLFDDLDSYIEIESAIKISAIKSDSYDFNMTIGEHTLTELDNTGFNVNWSMGNCNGVFPESSGSVAMLYASSGTDAGGEPQYKIFFSNESSEQWLGAGSVKVTFSFEDMITLETPALPWLSTKYQIIDPLAQETFDALKSRLGQSVKVHVEVFDAIRVTKDNPRDYKPNFILVDGKIKIE
>NZ_CP041201.1|WP_140330018.1|207156_207624_+|hypothetical-protein
MSGNFFKPSALGDSGNFGLIDSSGGGSIVISDTIKMTVGFIPFSTAYGYDGDFSLGSLEPGTVEIFGGNIKSLYFRASGGSHVMSLHVSETTATENLSTTMTIDDISFDANFVYSSDFATLTNDPIDGTIAGQIFSYLESKVDQVVTVKIVQKLV
>NZ_CP041201.1|WP_088581839.1|207650_207860_-|hypothetical-protein
MDLLHRIWTTQKAWLSSVFSLFASLGLQGTLQIVILLFGVIAGYFAFKRNRDEAKIAEIKLKKLSGANK
>NZ_CP041201.1|WP_128413547.1|207862_208174_-|hypothetical-protein
MSMKIFKKIISTFIGSLIDFIDEKVDDKEEANKLKAILEAYQKSAYLRLAETQASLIMAEYNGTWLQKNWRAIVMIIIAIAIVALGRTDLIDMLKIGLSGFIG

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Crispr_ID: NZ_CP041201_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP041201_2

671489-671622

Orphan

Consensus_repeat	Method
GGCGGTCGTCGTGAAGGTGGTTTCCGTGGTAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP041201_2

>merge|NZ_CP041201|2|671489-671622|CRISPRCasFinder
GGTGGTCGCCGTGACGGTGGTCGTCGCGATGGCGGTCGTCGTGAAGGTGGTTTCCGTGGTAACCGCGAAGGTGGCAACCGTGGTGGTGAGCGTCGTGAAGGCGGTCGTCGTGAAGGTGGCTTCCGTGGTAACCG

>NZ_CP041201|2|2|671489-671622|CRISPRCasFinder
GGTGGTCGCCGTGACGGTGGTCGTCGCGATGGCGG	TCGTCGTGAAGGTGGTTTCCGTGGTAACCGCGAAGGTGGCAACCGTGGTGGTGAGCGTCGTGAA
GGCGGTCGTCGTGAAGGTGGCTTCCGTGGTAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP041201.1\|WP_021450763.1\|675198_676512_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|206779
NZ_CP041201.1\|WP_005483343.1\|673567_673693_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_141179389.1\|680070_681675_-\|methylcrotonoyl-CoA-carboxylase	unknown	unknown	gnl\|CDD\|178415
NZ_CP041201.1\|WP_141179380.1\|659846_661019_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_CP041201.1\|WP_047725631.1\|678288_679191_-\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|180206
NZ_CP041201.1\|WP_023624680.1\|665117_665945_-\|phosphate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270371
NZ_CP041201.1\|WP_141179387.1\|677701_678253_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227700
NZ_CP041201.1\|WP_141179382.1\|662559_663774_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271184
NZ_CP041201.1\|WP_141179385.1\|667434_669441_-\|exoribonuclease-II	unknown	unknown	gnl\|CDD\|179920
NZ_CP041201.1\|WP_141179386.1\|671826_673428_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP041201.1\|WP_141179384.1\|666559_667363_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NZ_CP041201.1\|WP_141179723.1\|657752_658820_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP041201.1\|WP_141179383.1\|664383_665064_+\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239534
NZ_CP041201.1\|WP_021486992.1\|681709_682879_-\|isovaleryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173845
NZ_CP041201.1\|WP_017448087.1\|666156_666555_+\|DUF3024-domain-containing-protein	unknown	unknown	gnl\|CDD\|371425
NZ_CP041201.1\|WP_141179379.1\|658819_659863_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP041201.1\|WP_141179381.1\|661584_662445_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366451
NZ_CP041201.1\|WP_141179388.1\|679187_680033_-\|gamma-carboxygeranoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|235664
NZ_CP041201.1\|WP_005483382.1\|673725_674919_+\|acetate/propionate-family-kinase	unknown	unknown	gnl\|CDD\|183528
NZ_CP041201.1\|WP_005485953.1\|676797_677676_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769

Protein	Function_ID	Function_description	E-value
NZ_CP041201.1\|WP_021450763.1\|675198_676512_+\|PAS-domain-containing-protein	gnl\|CDD\|206779	cd11386, MCP_signal, Methyl-accepting chemotaxis protein (MCP), signaling domain. Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.	3.20812e-45
NZ_CP041201.1\|WP_047725631.1\|678288_679191_-\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|180206	PRK05692, PRK05692, hydroxymethylglutaryl-CoA lyase; Provisional.	9.09899e-179
NZ_CP041201.1\|WP_141179389.1\|680070_681675_-\|methylcrotonoyl-CoA-carboxylase	gnl\|CDD\|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
NZ_CP041201.1\|WP_141179380.1\|659846_661019_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	2.88786e-24
NZ_CP041201.1\|WP_023624680.1\|665117_665945_-\|phosphate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270371	cd13653, PBP2_phosphate_like_1, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.04054e-86
NZ_CP041201.1\|WP_141179387.1\|677701_678253_+\|hypothetical-protein	gnl\|CDD\|227700	COG5413, COG5413, Uncharacterized integral membrane protein [Function unknown].	2.74425e-23
NZ_CP041201.1\|WP_141179382.1\|662559_663774_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271184	cd01184, INT_C_like_1, Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain. Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain containing six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	3.97054e-58
NZ_CP041201.1\|WP_141179385.1\|667434_669441_-\|exoribonuclease-II	gnl\|CDD\|179920	PRK05054, PRK05054, exoribonuclease II; Provisional.	0
NZ_CP041201.1\|WP_141179386.1\|671826_673428_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	5.29061e-91
NZ_CP041201.1\|WP_141179384.1\|666559_667363_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.31096e-25
NZ_CP041201.1\|WP_141179723.1\|657752_658820_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.46504e-69
NZ_CP041201.1\|WP_141179383.1\|664383_665064_+\|MaoC-family-dehydratase	gnl\|CDD\|239534	cd03450, NodN, NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their legume hosts, a symbiotic process that requires production of Nod factors, which are signal molecules involved in root hair deformation and meristematic cell division. The nodulation gene products, including NodN, are involved in producing the Nod factors, however the role played by NodN is unclear.	2.34373e-68
NZ_CP041201.1\|WP_021486992.1\|681709_682879_-\|isovaleryl-CoA-dehydrogenase	gnl\|CDD\|173845	cd01156, IVD, Isovaleryl-CoA dehydrogenase. Isovaleryl-CoA dehydrogenase (IVD) is an is an acyl-CoA dehydrogenase, which catalyzes the third step in leucine catabolism, the conversion of isovaleryl-CoA (3-methylbutyryl-CoA) into 3-methylcrotonyl-CoA. IVD is a homotetramer and has the greatest affinity for small branched chain substrates.	0
NZ_CP041201.1\|WP_017448087.1\|666156_666555_+\|DUF3024-domain-containing-protein	gnl\|CDD\|371425	pfam11225, DUF3024, Protein of unknown function (DUF3024). This family of proteins has no known function.	5.55354e-20
NZ_CP041201.1\|WP_141179379.1\|658819_659863_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.75314e-56
NZ_CP041201.1\|WP_141179381.1\|661584_662445_-\|hypothetical-protein	gnl\|CDD\|366451	pfam01076, Mob_Pre, Plasmid recombination enzyme. With some plasmids, recombination can occur in a site specific manner that is independent of RecA. In such cases, the recombination event requires another protein called Pre. Pre is a plasmid recombination enzyme. This protein is also known as Mob (conjugative mobilisation).	5.1958e-26
NZ_CP041201.1\|WP_141179388.1\|679187_680033_-\|gamma-carboxygeranoyl-CoA-hydratase	gnl\|CDD\|235664	PRK05995, PRK05995, enoyl-CoA hydratase; Provisional.	7.16993e-96
NZ_CP041201.1\|WP_005483382.1\|673725_674919_+\|acetate/propionate-family-kinase	gnl\|CDD\|183528	PRK12440, PRK12440, acetate/propionate family kinase.	0
NZ_CP041201.1\|WP_005485953.1\|676797_677676_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	5.12613e-12

>NZ_CP041201.1|WP_141179385.1|667434_669441_-|exoribonuclease-II
MFQDNPLLAQLKQQIQENLPKKEGSIKATDKGFGFLEVDSKTSFFIPPAYMKKCIHGDKVVAIIRTENEREVAEPQELIEQSLTRFIGRVKMFKGKLNVVPDHPQLKKLSLKAKLKKGLKPDNFAEGDWVVAHLVRHPLKGDNTFFVEISEKITDADDKIAPWWVTLAQNDLPNSEPAGIENWELKDDADLERIDMTHVPFVTIDGESTKDMDDALYAKKTESGDFELTIAIADPTAYITPEDDMDKVARERGYTIYLPGRNIPMLPRDLADNLCSLIEGEIRPAICCTVTVSKDGVIGDDIKFFAANIKSHARLAYDHVSDWLENGNSDAWQPSEEIATIVRDLYEFSLARAEWREKNAVVFPDRPDYRFELSEDNDVIAIHADMRRSANRLVEESMITANICAGRTLREKFETGVFNTHAGLKPEKIEEVVQLVNPEGTLEFTAESIATLEGFAALRRWLAVQETSYLDNRIRKFQAYSEVGNQPLPHYAMGLDIYATWTSPIRKYGDMINHRMLKAVILDKEPVQKPDDQVGEELALHRKHHKIAERNVSDWLYARTLADEPSKQTCFTGEIFDINRAGARVRLLENGAAAFIPGALILDNKERIECNGDNGTISIDKEVVYKLGDTLEIVLADVNQENRSLVAKPTQVFADQPAAQTEQTVSEE
>NZ_CP041201.1|WP_141179384.1|666559_667363_-|helix-turn-helix-domain-containing-protein
MPNIEIIRFNHFTARKSERYTATHNGLYVVEEGALVVHQPNGEQFELKAGDFTLYNSSDLRSAEAIPGENGFKAVALVFDISLFCEFKKAHPGLHSEAEHRRFYPFSPESNSEITQLKNTLLVLASRNAPDYTQSHIAMALLSLMVEVQPDILSIIDDASSLTASQKAIKYIEKNIEKDITLEGLAAHMSMSIATLKRRLAAENLSFSQILKVKRINYAATQLRVSQKSITEIAFESGFKSTAHFSTAFKSIYNITPKDFRNQVVRG
>NZ_CP041201.1|WP_017448087.1|666156_666555_+|DUF3024-domain-containing-protein
MALGCILKTTYQENVMSVSQMATSRLYKLVQILCSARNANLPVEQGKCLYEPIENGVELHHAHFLLDSQHSEYTSPIAKILFDSQTQLWRFYVPASRSEEIRWIPYKKLPHSHTLEDLLAELESDPQACFWE
>NZ_CP041201.1|WP_023624680.1|665117_665945_-|phosphate-ABC-transporter-substrate-binding-protein
MLRFTVATLLAMAVSLPSAMAKEVNISGSTSVARVMDVLAEEYNKTHPDNYIAVQGIGSSAGITMVNKGVVKLGMSSRYLTESEKGEDLNVFPIAYDGLAVVVNRTNSVTNLSAQQLFDIYKGEIKNWKEVGGADQPIAVVTREASSGSRYSFESLLGLTKIINDRLVSDISPNNLVVNSNSMVKTIVNHNTRAIGFISVGSVDLSVKAIQFNGIEPTAANIANHKYKLARPFLVLYKVDSLDQAGKDFVAFLKSKAGQKTIADYGYIPVKNFNQ
>NZ_CP041201.1|WP_141179383.1|664383_665064_+|MaoC-family-dehydratase
MKVTNLFKDKVDAISAHQSEFMNWMSPTLRDYWSDFLGKAQNSFLFSNVRDHNQPAVNEEVAPQPAPIVLQPEAQKLYDELSGKIGEVIHTGGWVHVSQERINQFGAVTEDMQWIHTDPERASVESPFKTTIAHGFLTLALLPKLTDSVDADKPLFPTAKLVVNLGLNQVRFPYPVKAGNNVRAVSTLTKVTPIKKGLEIEREIKVEIEGVRRPGAVVVSVIQLHF
>NZ_CP041201.1|WP_141179382.1|662559_663774_-|tyrosine-type-recombinase/integrase
METKNRSEGLDRSLPIAIVARQWFKEMTDTPPTSVQSALQQLRLSVAHIKHNSYVSISKDAPRRLMSPHSIKPEKSEVTTRKRNDECSNEKWLEQFLSYKTHEGIRYSSVQQLGARSRLFLSLLNKPISQITSKDAINFKTYLITSSKAYKTQKETLSAVKQFVKWLKLQNVLSTSPFDGVIIKQPAVKASAERQRWSHDALARLFKHDNFKTIPSELTPQAKREDFWIPLILLLSGARTGEICQLMTRDIIRHNGTWCIDINDLGEDRHLKTAASKRLVPIHHKLIDWGLLEYVEYRRKHGKVNLFDLTPKGADKDWYKSFSVRFSRVLSAMGFIGKHRPTLHSFRHTFIDELQQQGIPEHETSELVGHTKLGISYGRYGKTVNIERLNKVIQTLSFNFPFAF
>NZ_CP041201.1|WP_141179381.1|661584_662445_-|hypothetical-protein
MNTTILRFEKHKHFANIRQAGAHQHRHHANTLNADKCRSNRNRIFIGSSNLVSDVKNRLKILQKKTRKNAVLAVDGVLTLSPALFRQGNREDQYQTLKKFAIASKRWLIQTFGENVVNAVLHLDETSPHVHFTVVPIERTLSGEYKLNARNMFNKQTLHDFQRNYFELMQQCFPELVPPKYREKATHTTLRAFYAGLNRLDGKITDFIETEFNQQKDKLRVEAETLIRQHIEEWLEQRFVNMPDDKIDSWVASVQKNLGWELDVLVDQPTFKPSLNETIKTKIILN
>NZ_CP041201.1|WP_141179380.1|659846_661019_-|serine/threonine-protein-phosphatase
MFQELLQKHLARGVLSRGLHSIDSGAIAIASDLGLRRTENQDRAAVMKFRSPTALYTLVAVVDGMGGMRDGEQAAELAISTFFNSVMESIHLGSEQAITQATLAANNAVFAFANGKGGSTLSALLLCSDDVNVTVNVGDSRIYAKDSVLSKLVRLSVDDSLAEAVGGSGTELLQFIGMGEGIKPHVAPLKSEISQVYLTTDGVHYIEPKTLSDIVENAGRVNQIVERLIATARWCGGPDNASICAVDLELLTFEEHVDDTTVIQVSDPYTSMQFIWGHSPVDQQAASHVSNQQINIEEKTTKVSNADELDNSVVDQADDEEPSDAEQKADSQEQLEAEPKTANKERPKRKSRTSKKKVDKKDSDEEVQIKMTICDDVSDDNGEVNNDSSN
>NZ_CP041201.1|WP_141179379.1|658819_659863_-|protein-kinase
MTLPTRYELSGTNDSGGMGDILYCKDKHLQRDVVIKLLKGDAEQRRLFDEQRSLIQLRSKHVVQLYDVVEVGEQIGLVLEFIQGEDLSGGAYQSDMNGLVETLWQVACGLSDIHAAGIIHRDIKPNNIRRDCSDVIKVFDFGLARKLDTAKTNSVIGTVGFMAPELWKQGEVEFTTAVDVYAFGITAMALANASVPRELLEYPPLPAPHKNWVQVSLPNLDADIVEILEQCLAYSPTARPSIVEVEKVLRRHLLKDKHKGLLVMGIQVKELNSQNRRANITSSVGAEITIEYDGYDFKVVAYVGDVTVNNDPVSIGYVMPGASVITLGPRSNRGFVTFDISNPEVVS
>NZ_CP041201.1|WP_141179723.1|657752_658820_-|protein-kinase
MIAPNTLIGDRYVVLEHVGAGGMQDVYRAKDNFLGGEVALKTPQPGQKTRRFQASAVIAGKVNHHNVAKTLDYFEENSEVYLIEEFVNGQTLEDKIQHRDFLDPHLAARTLHLLAKGIRASHLQGVIHRDLKPSNIMIDSSAGIEELKITDFGIATFTEEVFNEEAQSGDITRSTSGTVKGALPFMAPEMMFRKKGDQLTCALDIWSIGAMMFKLMTGEYPFGVFLDAAVNVKNQERLDWPTFMTANAQFAPLCRELQSIVDSCLEYDPAQRPSADDLVKMCQNLCYQTSERHEATVYRLIQNGYSGFAENQEHNVYFSIHSLYGATSVPTGSKISYSKFPGLPRDRAHPVIIEK
>NZ_CP041201.1|WP_141179386.1|671826_673428_-|EAL-domain-containing-protein
MPTIAFLLVILGLILLCWGWQMTKNICSKTEVPGWTWLLMLISCFIFAYAAFLHAIMKKPVASLLETGVSLLLFGGSIFVVLVIKWSNDSILELHSVAEREKRNAVHDSLTGLPNSKYCFELIDDRIQSGDPFSVILFDVVNFKQVNDAMGHFCGDQLLIQIGQRLQDKLKGNDKIFRVGGDEFVILTSSACEKTGTELIESLDCALSARFHLDEFQVSSRVVFGISTYPYDAISNDLLIKHADIAMYHAKRNGNLFAFYHDDMNVGAKYQLEISSRIQCALEKEEFQLYYQPLIDANTNLAVGFEAVIRWHDENGKTISPNDFIPIAERSNQVHNITMWVLGQVEKDLKTFIEKGIKLPVHVNLSAKDLSSNLLFHRLEKLLENNPQFADLISLEITETMAIDRVVELNPLIHQIKGLGIKISLDDFGTGYSSLSLLRDLPVDQIKIDRSFLCTANRTAGSRSIVENTIALAHGLGYSVVAEGVQDMDTLYFLRSRGCDIIQGYLFCPALPLNEVINWVNEHDDKQSHTRRA
>NZ_CP041201.1|WP_005483343.1|673567_673693_-|hypothetical-protein
MRFRAAYFLFAPLLFNNFLIFQQSFSESDLIEQILLIYSKF
>NZ_CP041201.1|WP_005483382.1|673725_674919_+|acetate/propionate-family-kinase
MSNSFVLVINSGSSSLKFAVIDSVSGDAVLSGLGECFGLSDARMSWKFNGEKKEISIEGDDSHHKIAIGKLVGLTEELGLAQDIVAVGHRIVHGGEKFTKTVRITEEVTQEIEKLADLAPLHNPAGAIGIRAAVEAFPSLPQFAVFDTAFHQTMPQRAFTGAIAKELYTDFGIRRYGFHGTSHYFVSREAAKMINKPIEESSFISVHLGNGASVCAINNGESVDTSMGFTPLSGLMMGTRCGDLDPGIIEYLLKKGWSQEKVFNSLNKASGFLGVSGLTSDARGILEAMEEGHEGAALAFQVFTYRVSKYIASYLAALDSFDGIIFTGGIGENSMPIRREILKNLKLLGFVEDVKGNEDARFGNAGVIATSELLGAKALVIPTNEEWVIAQQSVELL
>NZ_CP041201.1|WP_021450763.1|675198_676512_+|PAS-domain-containing-protein
MFFNKSLQQENQRLKQELYSLQQIQQSLDEEMLRLTLDAKGKVTSANQKFLQQLSLSDKDILAKHISDLVPSNVRNTDHFYRMKQSVQAKAFWNGAFQITKGDGEEAWLRVVIQPVRNTSDQVESFFVFASELTRTITTSREYEDMLNALSRSMAVIEFTLDGTVLKANDNFLSTMGYKHEQIVGKHHRIFCLPEEANSSAYHDFWKRLASGQFVTDRFKRVDQYGSVVWLEASYNPIHNDRGELYKVVKFATNITQQVLQEQSMAQAAQLANEVSQETGTQTVQGRQVIGSTLEKMQTLSEQMQQANAAIEDLKAHSSKISELVNSISGIADQTNLLALNAAIEAARAGDHGRGFAVVADEVRQLAMRTNTTTDEIVSMVTENLERTNNAVALISQCQKEALDTLELSEKAGNVMNDIQDGASRVVEAVAQFNRTL
>NZ_CP041201.1|WP_005485953.1|676797_677676_+|DMT-family-transporter
MFNSERKATVILVATTMIAALGWIFSKETIQGLPPFGFIGLRFTIASLCLLPLCYRPLKAARLKDVLAASGVGLLLGGAVMTWIYAISISDTLGEGAFIMSLSMLFVPIVAWVMFQQRPQRIFWISLPIAVIGLACLSLAGGWKQSASQLWFLGAALILALHFNVNSKYSQKLPVLLLTCVQLFSAGCLGLLVSFLMESRPEQVDSSIWWWFALSTLLATSLRYVMQTMGQKFVQAGNAALIMILEPVWTVVLSILWYGEVLTANKLVGCLLILFSLVIYRTGGRFRFPKRA
>NZ_CP041201.1|WP_141179387.1|677701_678253_+|hypothetical-protein
MANTEHQETLDFLDKLSVCLYRAGISVFAIELLGLAALESQWLDGMDGRYRAVFAVFTIAGAMSASNIHVYSKSVRTIISWSGWIGAILMVCDPELNRVWLALGFIFVTFSGIALKESFCFKVLGLKLVPMLLVVTTFALWFEQSTIVAISALLAGLIMAYLSIAKWCMPLHFDIGIKANYEV
>NZ_CP041201.1|WP_047725631.1|678288_679191_-|hydroxymethylglutaryl-CoA-lyase
MTLPTNVNIVEVGPRDGLQNESPVSTRTKIRLIDLLSDTGLSHIEAGSFVSPKWVPQMADSKEVMQNITRRASVTYSALTPNLQGLEQALDAGANQVAIFTSASEGFCQHNINCSIAESLKRFEPLMVQADKYHVPVRGYLSCVVDCPYDGATSPTQVANISQALIELGCYEVSLGDTIGTGTPNRVKEMLESVLASIPNQRLAVHFHDTWGQALANIYQALSMGITTVDSSVAGLGGCPYAHGASGNVATEDVLYLCQGLGIETGVDLELLAKAGWMISDELQRQPTSKVSQALRHRME
>NZ_CP041201.1|WP_141179388.1|679187_680033_-|gamma-carboxygeranoyl-CoA-hydratase
MQERQPSIVPNAQRHNDVLWQVDEFGVATLTLNRTKKHNAFDACMIDLIIHRLDYLALRTDVRCLVLRSNGKHFSSGADLAWMQSMANSTRKENLVDAQSLARLMETLDAFPQPTIAVVQGSAFGGALGLICCSDIAIASHSAQFCLSEVKLGLVPATIAPYVMRAMGNRQARRYILSGEVIPAVKAQQFGIAHEVKKDNELESCVSEVVASLLLNSPDAMRKAKALCEQCHQNPIDSQLIRYTSQLIADIRVSPQGQDGLQAFLEKRPPSWVHQPDAEEE
>NZ_CP041201.1|WP_141179389.1|680070_681675_-|methylcrotonoyl-CoA-carboxylase
MAIIKSKTKPTDELFLSNQAAMEMLVEKLQKDVATIKLGGGERAIAHQRQKGKLSVRERISHLLDDGSNFLEIGQFAAWQVYDESIPCAGVVAGIGMIEGIQCMVIANDPSVKGGTYYPLTVKKHLRAQEIAQRCQLPCVYLVDSGGANLPHQSDVFPDKDHFGRIFFNQARMSAKGIPQIAVVMGLCTAGGAYVPAMADVSIMVKEQGTIFLAGPPLVKAATGEVVTGEELGGADVHCRKSGVADYYAENDEHALGLAREAIANANRPKPPKSDSAILPPRYDAEEMYGIVNANLRLSFDVREIIARIVDDSDFDEFKALFGRTLVCGFARIHGQLIGIVANNGILFSDSSQKGAHFIELCAKRKTPLLFLQNITGFMVGKKVEEEGIAKHGAKLVMAVACADVPKFTVIIGGSYGAGNYGMCGRAYDPTMMWMWPNARISVMGGEQAAGVLTQVRKEINQRRGEEWSEQEEHTFKESIIDLYETQGHPYFASARLWDDGIIDPKETRNVLAQALMAALNAPIPDSEFGIFRM
>NZ_CP041201.1|WP_021486992.1|681709_682879_-|isovaleryl-CoA-dehydrogenase
MKTSYIPLNFGLGETIDMLRDHVNAFASEHIAPIAADIDHYNQFPSHLWPLLGEMGLLGVTVSEEYGGAEMGYLAHVVAMEEISRASASVALSYGAHSNLCVNQIFRNGTPTQREKYLPKLVDGSHIGALAMSEVNSGSDVVSMQLKAEDKGDHFLLNGTKMWITNGPDADVVVVYAKTDADAGSRGITAFIVERSFTGFSDAQKLDKLGMRGSNTSELVFNNCKVPKENILGALNCGVEVLMSGLDYERVVLAAGPLGIMQACMDIVVPYVHERKQFGKSIGEFQLVQGKLADMYSRMSAAKAYVYTVAAACDRGECTRKDAAGVILYSAELATQMALDAIQLLGGNGYINEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFEESR

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Crispr_ID: NZ_CP041201_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP041201_3

1763043-1763140

Orphan

Consensus_repeat	Method
TTTTTGAAAAGGCGTTTTAAAAATA	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP041201_3

>merge|NZ_CP041201|3|1763043-1763140|CRISPRCasFinder
TTTTTGAAAAGGCGTTTTAAAAATATTGATTGCGATCTTGTTTTTCTGGATTCTTTAATTGCGCGGTTTCAAATTTTTGAAAAGGCATTTTAAAAATA

>NZ_CP041201|3|3|1763043-1763140|CRISPRCasFinder
TTTTTGAAAAGGCGTTTTAAAAATA	TTGATTGCGATCTTGTTTTTCTGGATTCTTTAATTGCGCGGTTTCAAA
TTTTTGAAAAGGCATTTTAAAAATA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP041201.1\|WP_141179701.1\|1756057_1757797_+\|transporter	unknown	unknown	gnl\|CDD\|271371
NZ_CP041201.1\|WP_005482833.1\|1771191_1771653_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|226429
NZ_CP041201.1\|WP_005464966.1\|1769906_1770746_+\|S-formylglutathione-hydrolase	unknown	unknown	gnl\|CDD\|178061
NZ_CP041201.1\|WP_140082011.1\|1764064_1765933_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|225457
NZ_CP041201.1\|WP_005497706.1\|1761638_1762163_-\|YgjV-family-protein	unknown	unknown	gnl\|CDD\|378474
NZ_CP041201.1\|WP_141179700.1\|1755250_1755928_-\|porin	unknown	unknown	gnl\|CDD\|368776
NZ_CP041201.1\|WP_141179699.1\|1753006_1755235_-\|exopolygalacturonate-lyase	unknown	unknown	unknown
NZ_CP041201.1\|WP_005482884.1\|1758617_1759547_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|238571
NZ_CP041201.1\|WP_005464972.1\|1766646_1767516_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176159
NZ_CP041201.1\|WP_065787529.1\|1765935_1766646_+\|DNA-polymerase-III-subunit-epsilon	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236392
NZ_CP041201.1\|WP_005460834.1\|1757982_1758606_-\|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	unknown	unknown	gnl\|CDD\|235577
NZ_CP041201.1\|WP_141179702.1\|1759645_1760557_-\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|223730
NZ_CP041201.1\|WP_005464962.1\|1768696_1769845_+\|S-(hydroxymethyl)glutathione-dehydrogenase/class-III-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176260
NZ_CP041201.1\|WP_005467181.1\|1761310_1761631_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380366
NZ_CP041201.1\|WP_005497702.1\|1763183_1763981_+\|DNA-binding-transcriptional-regulator-KdgR	unknown	unknown	gnl\|CDD\|185046
NZ_CP041201.1\|WP_005464959.1\|1771652_1772744_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP041201.1\|WP_005460779.1\|1760634_1761270_-\|RpiB/LacA/LacB-family-sugar-phosphate-isomerase	unknown	unknown	gnl\|CDD\|181746
NZ_CP041201.1\|WP_141179703.1\|1767596_1768403_-\|arylamine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366312
NZ_CP041201.1\|WP_031822518.1\|1772753_1773158_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041201.1\|WP_005482916.1\|1762181_1762943_-\|2-dehydro-3-deoxy-D-gluconate-5-dehydrogenase-KduD	unknown	unknown	gnl\|CDD\|181605

Protein	Function_ID	Function_description	E-value
NZ_CP041201.1\|WP_141179701.1\|1756057_1757797_+\|transporter	gnl\|CDD\|271371	cd11477, SLC5sbd_u1, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	1.65659e-108
NZ_CP041201.1\|WP_005464966.1\|1769906_1770746_+\|S-formylglutathione-hydrolase	gnl\|CDD\|178061	PLN02442, PLN02442, S-formylglutathione hydrolase.	5.2905e-143
NZ_CP041201.1\|WP_140082011.1\|1764064_1765933_+\|CBS-domain-containing-protein	gnl\|CDD\|225457	COG2905, COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms].	2.84814e-139
NZ_CP041201.1\|WP_005497706.1\|1761638_1762163_-\|YgjV-family-protein	gnl\|CDD\|378474	pfam10688, Imp-YgjV, Bacterial inner membrane protein. This is a family of inner membrane proteins. Many of the members are YgjV protein.	9.00507e-50
NZ_CP041201.1\|WP_141179700.1\|1755250_1755928_-\|porin	gnl\|CDD\|368776	pfam06178, KdgM, Oligogalacturonate-specific porin protein (KdgM). This family consists of several bacterial proteins which are homologous to the oligogalacturonate-specific porin protein KdgM from Erwinia chrysanthemi. The phytopathogenic Gram-negative bacteria Erwinia chrysanthemi secretes pectinases, which are able to degrade the pectic polymers of plant cell walls, and uses the degradation products as a carbon source for growth. KdgM is a major outer membrane protein, whose synthesis is strongly induced in the presence of pectic derivatives. KdgM behaves like a voltage-dependent porin that is slightly selective for anions and that exhibits fast block in the presence of trigalacturonate. In contrast to most porins, KdgM seems to be monomeric.	1.34733e-23
NZ_CP041201.1\|WP_005482833.1\|1771191_1771653_+\|oxidoreductase	gnl\|CDD\|226429	COG3915, COG3915, Uncharacterized protein conserved in bacteria [Function unknown].	3.9997e-40
NZ_CP041201.1\|WP_005482884.1\|1758617_1759547_-\|sugar-kinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	1.15929e-102
NZ_CP041201.1\|WP_005464972.1\|1766646_1767516_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176159	cd08470, PBP2_CrgA_like_1, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 1. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.14139e-108
NZ_CP041201.1\|WP_065787529.1\|1765935_1766646_+\|DNA-polymerase-III-subunit-epsilon	gnl\|CDD\|236392	PRK09146, PRK09146, DNA polymerase III subunit epsilon; Validated.	4.69512e-40
NZ_CP041201.1\|WP_005460834.1\|1757982_1758606_-\|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	gnl\|CDD\|235577	PRK05718, PRK05718, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	4.28455e-121
NZ_CP041201.1\|WP_141179702.1\|1759645_1760557_-\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	5.97248e-18
NZ_CP041201.1\|WP_005464962.1\|1768696_1769845_+\|S-(hydroxymethyl)glutathione-dehydrogenase/class-III-alcohol-dehydrogenase	gnl\|CDD\|176260	cd08300, alcohol_DH_class_III, class III alcohol dehydrogenases. Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding.	0
NZ_CP041201.1\|WP_005467181.1\|1761310_1761631_-\|cupin-domain-containing-protein	gnl\|CDD\|380366	cd02238, cupin_KdgF, pectin degradation protein KdgF and related proteins, cupin domain. This family includes bacterial and archaeal pectin degradation protein KdgF that catalyzes the linearization of unsaturated uronates from both pectin and alginate, which are polysaccharides found in the cell walls of plants and brown algae, respectively, and represent an important source of carbon. These polysaccharides, mostly consisting of chains of uronates, can be metabolized by bacteria through a pathway of enzymatic steps to the key metabolite 2-keto-3-deoxygluconate (KDG). Pectin degradation is used by many plant-pathogenic bacteria during infection, and also, pectin and alginate can both represent abundant sources of carbohydrate for the production of biofuels. These proteins belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	1.13072e-54
NZ_CP041201.1\|WP_005497702.1\|1763183_1763981_+\|DNA-binding-transcriptional-regulator-KdgR	gnl\|CDD\|185046	PRK15090, PRK15090, DNA-binding transcriptional regulator KdgR; Provisional.	0
NZ_CP041201.1\|WP_005464959.1\|1771652_1772744_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	5.06677e-44
NZ_CP041201.1\|WP_005460779.1\|1760634_1761270_-\|RpiB/LacA/LacB-family-sugar-phosphate-isomerase	gnl\|CDD\|181746	PRK09273, PRK09273, hypothetical protein; Provisional.	2.15977e-144
NZ_CP041201.1\|WP_141179703.1\|1767596_1768403_-\|arylamine-N-acetyltransferase	gnl\|CDD\|366312	pfam00797, Acetyltransf_2, N-acetyltransferase. Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.	1.51131e-96
NZ_CP041201.1\|WP_005482916.1\|1762181_1762943_-\|2-dehydro-3-deoxy-D-gluconate-5-dehydrogenase-KduD	gnl\|CDD\|181605	PRK08993, PRK08993, 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD.	0

>NZ_CP041201.1|WP_005482916.1|1762181_1762943_-|2-dehydro-3-deoxy-D-gluconate-5-dehydrogenase-KduD
MILDSFNLEGKVAIVTGCDTGLGQGMALGLAKAGCDIVGVNISEPTETIEKVEAEGRKFVDIRANLMKLDDIPTIVDRAVTELGRIDILVNNAGIIRRNDAIEFSEQDWDDVMNINVKSVFFMSQAVAKQFIAQGEGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWASHGINVNAIAPGYMATNNTAALRADEQRNKEIVDRIPAARWGTPEDLAGPCVFLASKAADYINGYTIAVDGGWLAR
>NZ_CP041201.1|WP_005497706.1|1761638_1762163_-|YgjV-family-protein
MVDTTILAQALGFISFGLGFSVFYQKNDRHLKILMLIFNLNHLLHFLLLGSMVSALSALLSALRTTTAIFVSSKRVAAVFIVISLVSGFWVAEQWRDLWPIIGTVIGTYSVFCLSGIRMRIGFLLGASCWLTNNILVGSIGGTLLEMTVIVMNLLTIYRLHRQQSESMINQSSY
>NZ_CP041201.1|WP_005467181.1|1761310_1761631_-|cupin-domain-containing-protein
MFVFNQDIPMEDLGEGISRKVLAHSDNMMSVEVHFEEGAIGAMHSHPHEQLTYVLSGEFEFTIGDEKKIVKTGDTMYKEPNIEHGCVCLKAGVLIDTFTPMRKDFV
>NZ_CP041201.1|WP_005460779.1|1760634_1761270_-|RpiB/LacA/LacB-family-sugar-phosphate-isomerase
MKIALMMENSQAAKNAMVAGELNSVAGGLGHDVFNVGMTDENDHHLTYIHLGIMASILLNSKAVDFVVTGCGTGQGALMSCNLHPGVVCGYCLEPSDAFLFNQINNGNAISLAFAKGFGWAGELNVRYIFEKAFTGKRGEGYPIERAAPQQANAAILNNVKSAVAKDVVEGLRAIDQELVKTAVGSTQFQECFFAHCQVPEIAEYVKSLLD
>NZ_CP041201.1|WP_141179702.1|1759645_1760557_-|alpha/beta-hydrolase-fold-domain-containing-protein
MHVAPITSLQTWFPEHPVLPLWSEPQIPSHLVQSYQERNLNELLPDRAVFEITHPEIVVFEPEQSNGIGILLMPGGGYQRVSVDKEGADSARVLNQAGFTVFVMTYRMPNEGHEFGAWTPLADAQRAMRLVRQLPLASHLSSIGVLGFSAGGHVAASLATSHALDIYPLQDEADRVSAKPDFCALMYPVISMNTDIAHMGSRAELLANLERESDLLRFSLEKQVTSDMPPCFLLHASDDTAVSAENSLVFWQALRQHEIATEMHLFEQGKHGFGIRDAQGLPVAAWPQLLSAWLQNLAEKARR
>NZ_CP041201.1|WP_005482884.1|1758617_1759547_-|sugar-kinase
MNPISRVAIIGECMVELKKHDGVLQQGFGGDTLNTAVYLSRLTKQHGVETSYVTGLGHDPFSREMLTAWREEGINTDMVYLSEDKLPGIYAIETAEDGERSFFYWRNDAAAKYWLRERALLSLVKDLCQHQMIYLSGISLAIISDDCRQMLIELLTMCRKEGVKIAFDNNFRPKLWPNIEQARDFYSKILSVTDMAFLTFDDEVMLWGDKHEDEAISRTKNFGVKEIIVKRGADDCFVVTQDQQHTVAALKVDAVVDTTAAGDSFSAGYLAKRILGGDVAESALAGHKVAGTVIQHRGAIIPSQAMPTI
>NZ_CP041201.1|WP_005460834.1|1757982_1758606_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase
MKDLNQQLSEIKVVPVIAIKDAGKAVKLAQVLIENGLPCAEVTFRTEDAALAIKNMREAYPEMLIGAGTVLTSAQVDEAIDAGVDFIVSPGFNPTTVKYCQQRNVTIVPGVNNPSLVEQAMEMGLRTLKFFPAEPSGGVAMLKALSAVYPVKFMPTGGVSPSNVKDYLSISSVLACGGTWMVPGDLIDNEQWDELAKLVREVAGIIE
>NZ_CP041201.1|WP_141179701.1|1756057_1757797_+|transporter
MTLLDSMIVMIYLLFIGIAAWLFRRFSTSSNDFLQGGGTMMWWMAGATAFMTQFSAWTFTGAAAKAYEDGISVMFIFWGNALGFFVAAAFFARRYRRLRVETAMEVIRVRFGHTSEQLFTWLSFPLTLIACAIWMNGLASFFSAVFSIEMSTTILAMGVIVTLIAVSGGAWTVSVTNVIQLILLIAITLVIGYTALQRFDSPSEVFAYTTPIYGEQIRMPSLFVMWAIAMLLQQTMSNNHTLSCYRFLTTANDKDATKAAFVAGVLFVFAPVLWFMPAWFVAAQNIDLLAIYPALEQSANNAAYLYYIQHYMPQGLLGLVMVALVAATIAPLSSAHNRNAGIVVKSLYQVWFNPSATNRQQLMVGKIATIVSGVLATVTALLLASVESYSLFDMMIVFAAFIQMPINIPSLLALVSLKTPNWSGWATVMVGCAVSLFMIFIFDVQWLSSSPLTPRESKDLSVVATLAVHLLVTGGFFLFTRVFYAKEPPSIQQSRTALAIQLATPISDEEQSPINHKQGLYVGSITALAGMLLILAGVVLAGSSQSIFVAIGCIVLLFSLFLLQPTLHSKRAWQKQKTK
>NZ_CP041201.1|WP_141179700.1|1755250_1755928_-|porin
MKVRYLTSALLLAMTSGLAAAASVDIRHEYVPDRDGDEHRDRIYVSHRFDNQIGFSVEAKWNYKDGHMGNAGHETGVSYRWKATENFSLTPGINIDASPSGASVFKYNLTGAYKINDEWDVAARIRHGYKNTDDSRYNQLNLYANRKFEWGKLGVEAEYKDIHGGEGGWKDKGHDQLIDFKGEYTKLESGVIPFFAIAAITHKGDGSEFKDEYVPRFRVGLKYNF
>NZ_CP041201.1|WP_141179699.1|1753006_1755235_-|exopolygalacturonate-lyase
MKKHTLALCLAAILAPAAHAAEIKVEDLTWKAITFGQSTDMNFGSTILPEKVGVNQVTVNGDVVAAGTLASTFTIESRGGKLANSHEGLTFYYTELPTDVNFTLSADVVLEQLGPETGATPNRQEGAGLMVRDILGAERLVPQPEGHEEFPSASNMVMNLMRSHTRTNDGMTNINASFREGVYQPWGTPGNRLSRVDYVEGVPYGTAETYRMTLTRTNDGFKVSYRNGEKFVEQAVKGANANIVEMQNSDSQYVGFFASRNAKMTVSNVDLQLAAADTVDAPKYAAKQGELVFQIASSPRSATKEYPVQARANYSGEFEVLHNDKVVAKQTVTAGELFSQWLTLDSGANQMEVRFTAIDGPNKETQAHRYSVDVVSLPDPMTLYVAPNGSDKGNGSQAQPLDLATAVELLPAGGTIILKDGDYQGMEIPLTASGSVDKLKHLRAEGDNVRFVSELRHEGNYWHYQGIEVAGAQFIVHGSHNTFEKMVTHGAPDTGFVITSPENIGRALWASYNQVIESESYNNMDPSQINADGFAAKMRIGDGNTFIRCLSHHNIDDGWDLFNKVEDGANGAVTILDSISFSNGRTLDVANKGGTIGNGFKLGGEGIPVPHVVKNSLSFNNNMDGFTDNFNPGALVLSDNVSIDNKRFNYLFRKSPYSGEIEQGTFTNNRSYRFHVNSKYDDVINSAKSTGNALVENGTTYTSDGKAVDSKTLAPLKQASVIDTQQAIPGKQEAMQLKQLIH
>NZ_CP041201.1|WP_005497702.1|1763183_1763981_+|DNA-binding-transcriptional-regulator-KdgR
MKGATMEKSTQPEAVSSVLKVFHILQALGEQKAIGVSELSQRLMMSKATTYRFLQTMKSLGYVSQEGEADKYSLTLKLFELGAKSLEYVDLIELADKEMRHISEQTNEALHLGALDENAIIYIHKIDSGYNLRMQSRIGRRNPLYSTAIGKVLLSERDESFVRDVLSDVEFIKHTEKTLENTDQVLEELAKVRDFHYAEDNEEQEPGLRCIAAPIYDRFGQIIAGLSISFPTIRFDEERMEYYVGLLHQAGKNISEQLGYHDYPA
>NZ_CP041201.1|WP_140082011.1|1764064_1765933_+|CBS-domain-containing-protein
MGTSVTPNIFDFLIKIDPFDKLPEPVVESIANSVKVKYLVRGETIGFSALCDQRYLYIIRTGAIEQRTPNGELRARLGQDDQFGFTFLDPLENAEDGYQAEAIEDSLLYLIPHSELKLVSEEHPEFADYFAAQANVRLSSAVKYVCRKEEKGLFFRTVGEIASENIAIVDVNDSIRSVAQTMCGKQRSSCAVVMKEGEIIGLVTDRDMTKSVVAQDMDTNQPIADVMTPNPVLIEDDAKVIQAISLMLQYNIRCLPVVHGKQVKGLLTTTHLVHNHRTQSLFLIEKIKYASSLNALAALKEERQTIFQALVESGVSAEIQGRVMSMIMDAFTRRIIQLNEELLGPPPCDYAWLVAGSHARNEVHMLSDQDSAIVLSDDVTEEHKLYFTHLAMRVCNGLAACGYPLCDGKYMAASPKWCQPIRRWKEYYQKWVASPEYNKLLSISVFLEVRAIHGNREFVDQIQQHLHDCIQKSPSFIPALVRDAIDTQPPLGIFNNLVLEKGGENSNTLNIKKYALNLIIDLARIFSLAAGGSLTGTEERFRYAAQHGTLSKDSVENIIGAYRFITQVRFRHQLNAILAGTTPDNHIAPDDFSSFERKHLKDAFKIISELQDVAKLKFVKGA
>NZ_CP041201.1|WP_065787529.1|1765935_1766646_+|DNA-polymerase-III-subunit-epsilon
MIKRWFKRWETPLSPEQKRQAIHVVDDWPMVLKDYLQQPLVDDSTTLKDLSFVALDFETTGVDAQGDKILSIGVVDLTLDGIDIASSKEWYICHGQFIKPETAKINGLTPQDLAKGLPLDEGMNRLLERITGKVVLAHGCCIEKAFIHAYFSSRYQVEDFPAYFIDTLQIEKQFSYAGKSGAHSSYQLDDLRRYYHLPGYLSHSAASDALACAELFLVQSKKLTALPDVTLRQLMR
>NZ_CP041201.1|WP_005464972.1|1766646_1767516_-|LysR-family-transcriptional-regulator
MANWEGVSEFVAVAETNSFTGAAAKLKTSVAQISRRVSALEERLAVKLLHRTTRKVSLSEAGQLYYQQCKHLVEGLELAELAVTQMQTEPRGLLRVTAPVTYGEMNLAPLLHQFLEKYPRVDLDLVLTNQKLDLIEQGVDVAIRLGRLQDSSMIAKRLSSRQTYVCASPMYLERFGEPHTLSELGRHQCLVGSVDYWHFKENKRDKSLRVSGRIKCNSGFALVDAAKRGLGLVQLPDYYVQEALDSGELVEVLTDYRDDREGIWALYPQSRNLSPKVRLLIDFLAQELA
>NZ_CP041201.1|WP_141179703.1|1767596_1768403_-|arylamine-N-acetyltransferase
MNKTDLNAYLTKLGLPSELPADLESLHKIHVAQHRCLPFENFDISLQRGISVEIEDIIQKTVYHSRGGYCFELNGLMLDVLKTLGFEARSLLGRVHVMGTPTGRSHQITLVMLDEQAWIVDVGFGSNTPRAPLPFILNQVIQTDLQTFRFVEDAQFGYFLQVLSTDGTDTWNNLYSFDLEFVFAGDIACGNFFTSTSPHSRFTSARVAAKATESGLVTLLNYTLKYTSEGEQTELELEPGQAYLDALKEYFGIELDAQYSDLRPLPDA
>NZ_CP041201.1|WP_005464962.1|1768696_1769845_+|S-(hydroxymethyl)glutathione-dehydrogenase/class-III-alcohol-dehydrogenase
MTLEIKPGQTHIKSKAMVAWAAGEPLKMEEVDVQLPKAGEVLVRIVATGVCHTDAFTLSGDDPEGIFPSILGHEGGGIVEMVGEGVTSVEVGDHVIPLYTAECGECKFCKSGKTNLCQAVRETQGKGLMPDGTSRFSINGETIFHYMGCSTFSEYTVLPEISLAKVNKQAPLEEVCLLGCGVTTGMGAVLNTAKVEKGDTVAIFGLGGIGLSAIIGARMAGASRIIGIDINESKFDLAKQLGATDVINPQKFDKPIQEVIVEMTDGGVDYSFECIGNVNVMRQALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKGRSELPEIVNRYMAGEFGLQEFITHTMGLEDVNKAFDLMHEGKSIRTVIHMDK
>NZ_CP041201.1|WP_005464966.1|1769906_1770746_+|S-formylglutathione-hydrolase
MTIENVSQTKVFGGWHKQYTHDSKALNCTMRFAIFLPPNATKSNPVPALYWLSGLTCTDENFMQKAGAFRMAAELGIAIIAPDTSPRGEGVADDASYDLGQGAGFYLNATQAPWSLHYHMYDYVTQELPAIIEANFPVSDVKSISGHSMGGHGALTIGLKNPTLYRSISAFSPISNPMQCPWGQKAFTAYLGTDIESWKQYDASELLKKEKSPLPILVDQGDADGFLSEQLKPEVLLAAAKQHGSELNLRMQSGYDHSYYFISSFIDNHLNFHAKYLFA
>NZ_CP041201.1|WP_005482833.1|1771191_1771653_+|oxidoreductase
MKKIVSLSLLLFAPFLSANSITFSSPQQPSVTLKLEELQSLPTTSYTTDLPWIQQSSEFLGVKLSTLLTHVYGSIPEQVDIGSLNNYHSTLSRKDIVRYQPILAYQQDHHYIKVRNKGPYWVIYPLSQYPELDHNEYHAQMVWQVNEMKIKQK
>NZ_CP041201.1|WP_005464959.1|1771652_1772744_+|GGDEF-domain-containing-protein
MKLSEAYPIKQKNYSTTSKMLLLVFATSLLLANVILLQQTRVLAQSFTDEQKQATWFLFQLSKELSELVSEARRLDENVLKIEGAELQYELAWSRFDLLINSKDVYTFFSRNHIQQYFLQLFNEFKELEPLLVEAKTGDSQAAAQFYRATQTLYLNLVEFVNQNFRLTSQVYETQKDESQRLMKAQYMLFATFVLSILSLTYFFYRESHFHRKLALSDPLTGLGNRNALFVTLRNNTRNRTAFSLCLLDLNGFKNVNDTYGHQAGDTVLCEIAKRLKDMNIDSFSTYRMGGDEFAVVIESSDVDAEEAKKHIHSVFDTPVLNANNVSSLSTSIGVAHYPSDSDNVDFLISIADKRMYKMKFQR
>NZ_CP041201.1|WP_031822518.1|1772753_1773158_+|hypothetical-protein
MMRKFMQILLLLAVIAAGVLAWVFIPSHETIGQKTLEQALNDDYSLVGHRIYSTDPDAGNRFGYFVLATGQSIEEQEPFLVTSDQFIRMEQTGDNTLSVTVNGRIYQYHNDLWVPKSDGKLQHFLVSATTNYVR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP041202

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CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP041201

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection