CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP040750	Plantibacter sp. M259 chromosome, complete genome	23 crisprs	WYL,csa3,DEDDh	4	1	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP040750_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_1

21606-21694

Orphan

Consensus_repeat	Method
CGGTCACTGAGCTTGTCGAAGTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_1

>merge|NZ_CP040750|1|21606-21694|CRISPRCasFinder
CGGTCACTGAGCTTGTCGAAGTGCGGCACAGCTCGGGGACCGAAGCGGTGCGGACAGACTTCTCACGGTCGCTGAGCTTGTCGAAGTGC

>NZ_CP040750|1|1|21606-21694|CRISPRCasFinder
CGGTCACTGAGCTTGTCGAAGTGC	GGCACAGCTCGGGGACCGAAGCGGTGCGGACAGACTTCTCA
CGGTCGCTGAGCTTGTCGAAGTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138944508.1\|16693_17467_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|315383
NZ_CP040750.1\|WP_138944506.1\|13722_14937_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP040750.1\|WP_079706328.1\|17666_18626_+\|NAD(+)/NADH-kinase	unknown	unknown	gnl\|CDD\|223139
NZ_CP040750.1\|WP_138944505.1\|12883_13618_-\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP040750.1\|WP_138944515.1\|26194_27418_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP040750.1\|WP_138944516.1\|27439_28483_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176186
NZ_CP040750.1\|WP_138944504.1\|9320_10301_-\|Ku-protein	unknown	unknown	gnl\|CDD\|238408
NZ_CP040750.1\|WP_124769427.1\|23639_24065_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319899
NZ_CP040750.1\|WP_138944511.1\|20626_21352_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP040750.1\|WP_064295440.1\|28744_29065_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223393
NZ_CP040750.1\|WP_138944517.1\|30273_30822_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|223340
NZ_CP040750.1\|WP_086475369.1\|29129_30155_-\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|240135
NZ_CP040750.1\|WP_138944512.1\|21739_23011_-\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP040750.1\|WP_064296128.1\|20045_20561_-\|CarD-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224248
NZ_CP040750.1\|WP_138944510.1\|19580_19979_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138947149.1\|30843_32235_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP040750.1\|WP_138944513.1\|24201_25434_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340830
NZ_CP040750.1\|WP_138944514.1\|25430_26198_+\|GlcNAc-PI-de-N-acetylase	unknown	unknown	gnl\|CDD\|274584
NZ_CP040750.1\|WP_138944507.1\|16189_16651_+\|DUF3817-domain-containing-protein	unknown	unknown	gnl\|CDD\|378962
NZ_CP040750.1\|WP_138944509.1\|18673_19513_-\|SIP-domain-containing-protein	unknown	unknown	gnl\|CDD\|99790

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138944508.1\|16693_17467_-\|alpha/beta-hydrolase	gnl\|CDD\|315383	pfam12695, Abhydrolase_5, Alpha/beta hydrolase family. This family contains a diverse range of alpha/beta hydrolase enzymes.	9.11268e-42
NZ_CP040750.1\|WP_138944506.1\|13722_14937_+\|hypothetical-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	4.73535e-19
NZ_CP040750.1\|WP_079706328.1\|17666_18626_+\|NAD(+)/NADH-kinase	gnl\|CDD\|223139	COG0061, nadF, NAD kinase [Coenzyme metabolism].	7.29292e-52
NZ_CP040750.1\|WP_138944505.1\|12883_13618_-\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.82763e-32
NZ_CP040750.1\|WP_138944515.1\|26194_27418_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.13044e-61
NZ_CP040750.1\|WP_138944516.1\|27439_28483_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176186	cd05283, CAD1, Cinnamyl alcohol dehydrogenases (CAD). Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NZ_CP040750.1\|WP_138944504.1\|9320_10301_-\|Ku-protein	gnl\|CDD\|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	1.77934e-111
NZ_CP040750.1\|WP_124769427.1\|23639_24065_-\|VOC-family-protein	gnl\|CDD\|319899	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins. The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.	3.33216e-39
NZ_CP040750.1\|WP_138944511.1\|20626_21352_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.06753e-08
NZ_CP040750.1\|WP_064295440.1\|28744_29065_+\|hypothetical-protein	gnl\|CDD\|223393	COG0316, sufA, Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones].	0.000437315
NZ_CP040750.1\|WP_138944517.1\|30273_30822_+\|dihydrofolate-reductase	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	1.15864e-17
NZ_CP040750.1\|WP_086475369.1\|29129_30155_-\|ATP-dependent-DNA-ligase	gnl\|CDD\|240135	cd04865, LigD_Pol_like_2, LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The Pol domains of PaeLigD and Mycobacterium tuberculosis (Mt)LigD are stimulated by manganese, are error-prone, and prefer adding rNTPs to dNTPs in vitro; however PaeLigD and MtLigD belong to other subgroups, proteins in this subgroup await functional characterization.	1.8407e-109
NZ_CP040750.1\|WP_138944512.1\|21739_23011_-\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.27822e-16
NZ_CP040750.1\|WP_064296128.1\|20045_20561_-\|CarD-family-transcriptional-regulator	gnl\|CDD\|224248	COG1329, COG1329, Transcriptional regulators, similar to M. xanthus CarD [Transcription].	4.90036e-53
NZ_CP040750.1\|WP_138947149.1\|30843_32235_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.96739e-60
NZ_CP040750.1\|WP_138944513.1\|24201_25434_+\|glycosyltransferase	gnl\|CDD\|340830	cd03800, GT4_sucrose_synthase, sucrose-phosphate synthase and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.	7.26323e-99
NZ_CP040750.1\|WP_138944514.1\|25430_26198_+\|GlcNAc-PI-de-N-acetylase	gnl\|CDD\|274584	TIGR03445, mycothiol_MshB, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase. Members of this protein family are N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, also called 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, the MshB protein of mycothiol biosynthesis in Mycobacterium tuberculosis and related species. [Cellular processes, Detoxification].	5.75599e-34
NZ_CP040750.1\|WP_138944507.1\|16189_16651_+\|DUF3817-domain-containing-protein	gnl\|CDD\|378962	pfam12823, DUF3817, Domain of unknown function (DUF3817). This domain is of unknown function. It is sometimes found adjacent to pfam07690 and pfam03176 which are both transporter domains.	1.69098e-21
NZ_CP040750.1\|WP_138944509.1\|18673_19513_-\|SIP-domain-containing-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.25755e-85

>NZ_CP040750.1|WP_138944511.1|20626_21352_-|TetR-family-transcriptional-regulator
MPRTSGVPALGVEQSTTERPAPPSRVEGFAPVLRVTGDPRAERTRQTIFDAVATILVGRPERVSVGDIVRVAGISRSSFYAHFSSLDDLTAAYLRVQFAGLAASGVSVRPAGESLGSAERAREAYRRLVAQLLEDAPLYSSVLELPVARSAFDDLVGEHADHLIGSLLERTEVPVGIPAGLVSAYVAGGTLSLVDGWRRGRIDVSDDELVEALVALLPAWLLDERPVGASPPPPTPEPSGR
>NZ_CP040750.1|WP_064296128.1|20045_20561_-|CarD-family-transcriptional-regulator
MQFIVGETLVYPHHGAVTITELSKVTIKGVEQDVMTLRVHTSELTIKLPIANADLVGVRDVIDHDGVQAVYGVLREPFVEEPGNWSRRYKANQEKMASGNVHRVGEVVRDLWRRDQDSGVSAGEKRMLQKARQVLVSELALAQSMTDEEASAGLDEVLASSIATPEAVAAK
>NZ_CP040750.1|WP_138944510.1|19580_19979_+|hypothetical-protein
MATTAGWYPHPDDPTKELHFDGEAWGDSRVLRFQRDKPSQADAAGWYPHPTDEERQVHFDGRAWTDMRVLQLSGGASGDGGQAPVYVSPAELPAPERESRAWTITKAALSFGPIIAIAVVGVLAIVSGNTGG
>NZ_CP040750.1|WP_138944509.1|18673_19513_-|SIP-domain-containing-protein
MTTTPRPRAPRPQIILEVVRSSWVTPHLVRLTLGGPGFADFQPKDATDSYVKISFAKPELGLEPPYDLAALRETLAPADLPVTRTYTVRRVDQAAGTIDIDFVVHGDEGIAGPWAAAAQPGDRVVLAGPGGAYRPEPTADWHLFAGDESAIPAIAAALEALPADAKGLAFLEIGGRDDLVDLDHPAGVQLIWVGRAARDESTAALLATAISGHPWPDGRVQVFAHGERESMKALREVFLTQRGLDRSQLSLSGYWAYGRTEDRFQAEKREPIGVVLPTS
>NZ_CP040750.1|WP_079706328.1|17666_18626_+|NAD(+)/NADH-kinase
MTIGLITHPTKNIDDSVRILRSWQLEHGARLVGLRAEANRLGDDVELLDEDAFASSVDVAVAMGGDGTMLGAMRLLAGRSAPVLGVNYGNVGFLVEVEPAALAEALQRVSDNEFSLEPHHGLEVTITTGEQVAHLLAFNDVSIARRPGTGVVMADLAVDGTAYGYFKADAIVIATPTGSTAYNYAAGGPVLSPAVAATVVTPVAPMSGIDRSFILGPAERLQFSIGTATKQAAVEIDGQVLADVASGAVVTVRLVRDAANVVRLDPSRHSRKGRMKLSLLDLPLRRDQLLDLVPPDIRARVERPSRVRRTRSKPADPSH
>NZ_CP040750.1|WP_138944508.1|16693_17467_-|alpha/beta-hydrolase
MSDVTEHPGRPRRAGRLKPILIGILCAVLVVVLGFVVWTQIVMQGTRPAALTVWENPAVSVTDVGDAVVLAPTADAERPASGTGLVFIPGAKVDPYAYLYKLSGVVEEAGVTVVITKPTLNLAFFDQRPLETFTAAAADVDTWFVGGHSLGGVRACQLAEDPAVTGLVLFGSYCANDLSGSALEVLSLAGSDDGLSTPDKVADARVRLPADATMIEIDGANHASFGDYGVQPGDGSATISSDEARSEITRDLVELLG
>NZ_CP040750.1|WP_138944507.1|16189_16651_+|DUF3817-domain-containing-protein
MSPRRLFRLIAIAEAITWTLLIIGMILKYVTKTTDVGVSIGGALHGFVFLVYGATVLLIGINQRWPIGTILVGLVSAVVPYATIPFDLWADRTGRLDGAWRREAGADPRDQRVLDRLTRWLVRHPILLVVVGGLVVVAVFTALLVVGPPVPKG
>NZ_CP040750.1|WP_138944506.1|13722_14937_+|hypothetical-protein
MTQEARTARAERWSDSRAFITASGAMAAVFGLAVSFQSVYIYTWVAPGGTRGMLAERVTANLVSLSAAILVLALLLWSRWGPSLHEWWRPKVLAGVLLVAMLTGLLRSGLQLLLGVYRDPSLQTVIVEAGTTTLALAVCATFGFSLSAARRRAREEERAHADQRHRADLALQSLQGEELRVKREVAEGLHGTLQQHLVLISAQLASVTTALEQGGPDVGSDAARTLRSLGEELRTVRERDVRELSRLLSPPLLEVGIAPSIRAILQRLPPSITTSLDVSPDFRLLDDPIDNVFTTAERAVVVRTLEEGVTNALTHGAADRLVVDLRVSSPATERRGTMAGAVELRVVDNGSGLRDDAEPSGGLLQLDRRAGAFGGSLRVGPAPDDETGGTVLTLTMPYRSPAIR
>NZ_CP040750.1|WP_138944505.1|12883_13618_-|response-regulator
MHHQSHSDPSPAALSTVGDATTAAATTRPLRVGVIEDQPLLGGMLAELLEGAPGVEFVGRAGTVAEARRLFLPGTVDVLTMDIELPDGNGVSLGVSLRRAQPGLGVVLLSAYDLMDMLLEMPADVRDGWSYLSKTSSLTREILLEAIRVSARGETMLDPELIDRTRPRAGSSLESLTDRQYAVLQLLATGRSNTGIATRLGIAEKSVQNHLTAIYAALGIEHDTSSNPRVSAVLALLAESGRLS
>NZ_CP040750.1|WP_138944504.1|9320_10301_-|Ku-protein
MRAIWKGAVTFGLVNVPVKVYSATEDHDVSLHQVHDADGGRIRYQRKCEVCGKVVTYDHIDKAYQDGEQTVVLTADDLASLPEERSREIEVVEFVPSDDLDPIMFDRSYFLEPDSSSSKAYVLLRRTLEETDRTAIVRFALRQKTRLGALRVREDVILLQTLLWEDEVREVRFPALEERVRISAKELEMSEALVESFSSRFRPDAFVDEYQAQLRKLIDAKLEQGDALDTAATFGEQPEPDDDTGAEPIDLMEVLQRSIERQRGTTGAKTASGAKRSGAAKPAARSGSAKAGTAKTGTAKTSGAKTGTDKTAASKPSTATKRKKSA
>NZ_CP040750.1|WP_138944512.1|21739_23011_-|DUF222-domain-containing-protein
MTETTLTAIRVGDEHAAQLAEFSDEWTEIHRQQALLDARKARLLARSAAYADAFADVAVPASFPPAERRALSRRSTCAALAMATRMPERTVQRATNDAERLVNDAPAVLASLEAGRISARHAQVITDQLCDVPTAGRAVFLEQVLVVAERSTAAGLRMSARVLRERLHPESITARATRSEADRRVEFEPAADGMAWVHLFTTAPIAQGIVERVETAAAESRNAGDTRTCAQLQADALTALALTGVTPEDVMSSPVLPHPIEVQEHIKPTVQITVPALTMAGVSDAPATLYGYGPIDPETAARIAVNAPSFTRILVQPETSAVLSVGRNQYRVPADLQRAVRLRDGTCRAPGCGRRARACDLDHSVAWEDGGTTDVGNLACLCRHHHRMKHLPGWNLDHGPGGVLEWTTPDGKHHRTEPDPAPF
>NZ_CP040750.1|WP_124769427.1|23639_24065_-|VOC-family-protein
MMTTLNPYLGFRGTAREAMEFYQGVFGGELLLSTFRDFGAEVEPDELDLVMHAQLTGDAGVVFMASDTPKHMDYSRGSDFSMSLSGPNEDEAQLTGYFDSLAAGGTVQQPLTVAPWGDSFGMLQDRFGVAWMVNIAAPAAA
>NZ_CP040750.1|WP_138944513.1|24201_25434_+|glycosyltransferase
MPSQPQPLRIAMISLHTSPGDEPGSGDAGGMNVVVRHQAVAMGAAGHEVDVITRRSSADQPSAASLAPGVTLRFLDAGPAEPVAKGRHEEFVEDFRSELARLPRYDVLHAHHWFSGMAALPLARELGIPHVQSFHSIAAESTTPLSHGERAESPGRLAGEARLAAESDAVVAISAAEADTAITRLGASPDRVSIVPPGVDGTLFHPLDGPRAGRPTAVVAGRLHPLKGFDLAIETIAAVAPELRPELVIAGDVSVDYDRYAEELAALARDLGVADDVRFVGPQSRIGLATLFRESMLVLVPSHSETYGLVALEAAASGVPTVVAASGGLREAVVDGGTGIVIDSRDPQVWGAAVSSILGDPGRLAQLGSAARRRAERFDWQRSGDALVDVYRTLLDTTPAVVTAPATSAS
>NZ_CP040750.1|WP_138944514.1|25430_26198_+|GlcNAc-PI-de-N-acetylase
MNRGLLPLVDSGHTVLFTHAHPDDETLASGALIAELADRGARVVLVTATRGERGEVVDGPLRSLAGTAALASHRESELAAACRTLGVAEQFWLGTTPAARPGTSTRYVDSGMRWVREGLAGPADDVSPGAFSLAPLDDVADDLVALIGHVSPDLVISYDHGGGYGHPDHLRMHEAAIVAARRSGVPFAELVHHRTDLEPSGDDAVWFPLEHRLPIVAAALAEHASQLTVDGEQLVHSGGQREDITTSVGLRLRSR
>NZ_CP040750.1|WP_138944515.1|26194_27418_-|MFS-transporter
MIRLPFRRPGGAGAVPREPLGREVLVLGGVAFFVMLGFGVVIPVLPVYVRSFGVGYLEVGAVVSVFALMRLIANPFVGALVDRIGERVVLATGIGIVAVSSALVGLAADYPQLLLLRGVGGIGSAMFSVAAMTLLLRTSPPHRRGRAVGFYQGGFLVGGMAGPAVGGLLSTISLTAPFFFYAGTLAVAGVLGLVMLRGSRIAAPVETATQAEPFRTVLADRRYQAALLANFANGWASMGVRGALVPVLVVEALHEEAAWTGIAFAIAAVAQTLALGPAGRFVDTVGRRPAMLVAFPVAAAALLAMPFVGELWLLVVALCVYGVAAAFLGTAPAAAVGDAAGGRGGRAVAVFQATSDLGAIVGPLVAGALLDAFSFPAAFGSAVVLMLLVPVLAARMPREHRNQSATA
>NZ_CP040750.1|WP_138944516.1|27439_28483_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MTTVAAIIKPTADAPFEVGTIVRRAPRANDVVIDVHYAGICHSDIHQAREEWGKAIFPMVPGHEIAGIVTEVGDAVTKHQVGDRVGIGCFVDSCRECENCLAGEEQFCLKGNVATYNGREYDGEPTYGGYSKQIVADENYVLSIPEGIELDVAAPLLCAGITTYSPLKHWGAGPGKQVAIVGMGGLGHMGVKIAHALGAEVTVLSQTTSKEEDGKRFGADHYYATGEEGTLKSLRGRFDLIINTVSADLDIDAYLSTLKLNGSMVFVGLPENTQQFRVFSLVGGRRSLAGSNIGGIRETQEMLDYCAEHGIGSQIELIGADEVEGAYDRVVRSDVRYRFVIDTATIG
>NZ_CP040750.1|WP_064295440.1|28744_29065_+|hypothetical-protein
MLTLTENAGRVVKTLAENAPLTPGLVVPDDASSLTHGAGLRISSSSDDNNFEVTMTATPHEADQVIESAGATVFLEESAAVALSDAVLDAQIDEQGGVRFALGKAE
>NZ_CP040750.1|WP_086475369.1|29129_30155_-|ATP-dependent-DNA-ligase
MASTAIVLTVPGPHGDREVRLSSPDRVLWEESGVTKRELAEYLIEVAPAFLAANGDRPVSLQRFPGGVDGEWFFSKNPPKGAPEYVRAVDVVYPSGRRHPQLVLDEAAAVVWAAQMNTVVFHPWPSRASDTDHPDELRIDLDPQPGTDFADAVRVAGSLRELLTEVGLTGFVKTSGNRGVHVFAPIEPEHEFLDVRHAVIAAARELERRDPDRVTTSWWKEERGERIFVDYNQANRDRTMAGAYSPRALASATVSCPVTWDELPEIDPGAFTVRTVPERLRTTGDPWAGMHDTAGRIDVLLQWWERDLEQGLGELPFPPDFPKMPGEPPRVQPSRARHSED
>NZ_CP040750.1|WP_138944517.1|30273_30822_+|dihydrofolate-reductase
MREVHASLFQSVDGVVESPDQWQFDHFDADMGAMMTEAIAPIDDVLLGRVSYEQWSGFWPTVGDDDPFGSFINPVRKHVASRTLAGPLSWENATLIPGTLESFVEELKQQDGGRIAVQASISVVRQLLFAGLLDRLTLMIHPVVAGAGRHLFEPSDPVTRLELVHSVRTSSGNVLSTYAPRA
>NZ_CP040750.1|WP_138947149.1|30843_32235_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MTQLIVVLDGTIVNIALPAAQQELELSDTQRQWVVTAYALAFGALLLLGGRIADYWGRKRTYLVGMVGFGAASAFGGFAQSGTELIVARGLQGVFAALMAPAALALLTVTFSHGRDRNTAFAVFGTVAGAGAAVGLILGGVLTEFVDWRWCLLVNVPFVIVGLIAGLILVTESKAEGDNRYDWLGAITVILGLGSLVYGFTLAEGGWGSADTIGFLALGAGLLSLFVFIEMRVAQPLLPLRIVADRVRGGAFLMQMIVGSVMIGALLYLTFHLQIVLGFPPLEAGIATLPMTVAIMIVAPIATKLLPAIGPRPLLIVGPLIAAAALVYLSRITADGDYFVQVLPALLVLGIGMAMIFVPMQNLALTGVAPHDAGAASATANASMQIGGSIGLSVFTTVYASVIDQATVTDQTSQLVAFTQGYSAAFIAAAVGLVIASVIAVVCIRGRKEDLLPSGDQQAVHLG

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Crispr_ID: NZ_CP040750_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_2

249280-249368

Orphan

Consensus_repeat	Method
GCGAACGGGTTGTTCCCCGGACGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_2

>merge|NZ_CP040750|2|249280-249368|CRISPRCasFinder
GCGAACGGGTTGTTCCCCGGACGCGGCGTGCCGGTCGGGCGCTGGCCCATGCCCTGCGAGGACGCGAACGGGTTGTTCCCCGGACGCGG

>NZ_CP040750|2|2|249280-249368|CRISPRCasFinder
GCGAACGGGTTGTTCCCCGGACGCGG	CGTGCCGGTCGGGCGCTGGCCCATGCCCTGCGAGGAC
GCGAACGGGTTGTTCCCCGGACGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138944644.1\|251606_253316_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP040750.1\|WP_138944643.1\|250123_250393_-\|DUF448-domain-containing-protein	unknown	unknown	gnl\|CDD\|377288
NZ_CP040750.1\|WP_138944651.1\|260063_260531_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138944646.1\|254092_255019_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380141
NZ_CP040750.1\|WP_168223266.1\|243821_245039_-\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|235113
NZ_CP040750.1\|WP_064294502.1\|242005_242938_-\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NZ_CP040750.1\|WP_138944637.1\|240776_242006_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340897
NZ_CP040750.1\|WP_083397443.1\|239628_240630_-\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_CP040750.1\|WP_071262338.1\|238609_239632_-\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|188646
NZ_CP040750.1\|WP_138944638.1\|242934_243354_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138944652.1\|260517_261444_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP040750.1\|WP_138944645.1\|253312_253993_+\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_CP040750.1\|WP_168223448.1\|245567_246419_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP040750.1\|WP_138944650.1\|259074_260073_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238744
NZ_CP040750.1\|WP_138944636.1\|237106_238603_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143429
NZ_CP040750.1\|WP_079707160.1\|250398_251400_-\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061
NZ_CP040750.1\|WP_138944639.1\|243456_243825_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138944649.1\|258037_259078_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|379234
NZ_CP040750.1\|WP_138944647.1\|255066_256824_-\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NZ_CP040750.1\|WP_079707157.1\|246511_246949_-\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138944643.1\|250123_250393_-\|DUF448-domain-containing-protein	gnl\|CDD\|377288	pfam04296, DUF448, Protein of unknown function (DUF448).	2.40798e-22
NZ_CP040750.1\|WP_138944646.1\|254092_255019_+\|hypothetical-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	0.000248453
NZ_CP040750.1\|WP_168223266.1\|243821_245039_-\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|235113	PRK03287, truB, tRNA pseudouridine synthase B; Provisional.	5.69315e-139
NZ_CP040750.1\|WP_064294502.1\|242005_242938_-\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	2.26819e-128
NZ_CP040750.1\|WP_083397443.1\|239628_240630_-\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	6.8917e-88
NZ_CP040750.1\|WP_138944637.1\|240776_242006_-\|MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.0678e-100
NZ_CP040750.1\|WP_168223448.1\|245567_246419_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	2.5468e-86
NZ_CP040750.1\|WP_071262338.1\|238609_239632_-\|deoxyribose-phosphate-aldolase	gnl\|CDD\|188646	cd00959, DeoC, 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. DERA belongs to the class I aldolases and catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. DERA is unique in catalyzing the aldol reaction between two aldehydes, and its broad substrate specificity confers considerable utility as a biocatalyst, offering an environmentally benign alternative to chiral transition metal catalysis of the asymmetric aldol reaction.	3.52564e-69
NZ_CP040750.1\|WP_079707160.1\|250398_251400_-\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	3.17347e-167
NZ_CP040750.1\|WP_138944652.1\|260517_261444_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.88801e-24
NZ_CP040750.1\|WP_138944645.1\|253312_253993_+\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.22322e-77
NZ_CP040750.1\|WP_138944644.1\|251606_253316_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.17363e-49
NZ_CP040750.1\|WP_138944650.1\|259074_260073_-\|VWA-domain-containing-protein	gnl\|CDD\|238744	cd01467, vWA_BatA_type, VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.	3.24966e-17
NZ_CP040750.1\|WP_138944636.1\|237106_238603_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143429	cd07111, ALDH_F16, Aldehyde dehydrogenase family 16A1-like. Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.	0
NZ_CP040750.1\|WP_138944649.1\|258037_259078_-\|VWA-domain-containing-protein	gnl\|CDD\|379234	pfam13519, VWA_2, von Willebrand factor type A domain.	1.67808e-09
NZ_CP040750.1\|WP_138944647.1\|255066_256824_-\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NZ_CP040750.1\|WP_079707157.1\|246511_246949_-\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	1.36818e-46

>NZ_CP040750.1|WP_079707157.1|246511_246949_-|30S-ribosome-binding-factor-RbfA
MAENPRARKLADRIKEVIAKRLDKGIRDPRLGFVTITDVQVTGDLQHANVFYTVYGSDEERADTSAALESAKGLLRAEIGRNINTRLTPSLDFFLDAIPENAQHIEDLLREAKNRDTEVAGLAAGAAYAGDEDPYVKPRDVDAED
>NZ_CP040750.1|WP_168223448.1|245567_246419_+|A/G-specific-adenine-glycosylase
MTGWFRTNARDLPWRRPGFPAWGTLVSEFMLQQTQVSRVIPRLEEWLGRWPTPADLAAEPPAEAVRAWGRLGYPRRALWLHAAATQIAERHDGIVPSDVDQLLALTGIGDYTARAVAVFAYGDRHPVVDTNTRRVIARAVRGQGEPGPPNAKVDLPAMEALLPESRSEAAVFNAGLMEIGAVVCTARAPRCEECPLREVCAWRAAGYPAYDGPVKTKQKQFAGSDRQVRGIIMAELRSTHRSLSDEELRALWPDGEQFDRALAGLVADRLAVCVDGGYALPHD
>NZ_CP040750.1|WP_168223266.1|243821_245039_-|tRNA-pseudouridine(55)-synthase-TruB
MRRSGSTSRWRRPTSGCTSASASTATRRRRPTHATWAGRRSTARTTTRPRGRPPSWTTRTSGTHGGSSPTSAERRRPGVLRAPGCADRRWYRCRVVENSTAAPGSASARPGILLIDKPQGHTSHDAVARVRRLAGTRKVGHAGTLDPMATGLLVLGTRSSTRLLTFIVGLDKEYTATIRLGAATSTDDAEGEVTERADQAAVAAVDDDAIIAAIRPLTGDIEQVPSTVSAIKVGGKRAYALAREGIEVELKSRAVTVSAFDVLTIRRDGAAVDVDVRVVCSSGTYIRALARDLGASLSVGGHLTALRRTRIGPFDVTDASTIDDLDVETALLHPADVAKRLFGALELTEQEAVDLGHGKRLERDLPAGHTGPIAAVAPDGRLVGLVERRGGSLKSVVNFPAEETA
>NZ_CP040750.1|WP_138944639.1|243456_243825_-|hypothetical-protein
MIEWFTIAQIAVAVVAGLLCIVLGFAGRAPNDLTMGATALVEVLLIAQLVVAIAAPAFGNTATGSVPEFYTYLVSAMILPIAGGFWALVERTRWSTVVLGVVCLAIAVMLYRMEQIWTVQLG
>NZ_CP040750.1|WP_138944638.1|242934_243354_-|hypothetical-protein
MPLPTAAPARPRVRGVGVVLVAVYGILALAATGRSVVQITTKFDEAPLAYLLSAVAAVVYILATVSLVAPGAVWRRIAWATISFELAGVLIVGLLSLLDPELFPHDTVWSGFGRGYVYIPLVLPVLGLWWLAGHRRTGK
>NZ_CP040750.1|WP_064294502.1|242005_242938_-|bifunctional-riboflavin-kinase/FAD-synthetase
MITFTELDQVPDAFGPSAVTIGKFDGVHTGHRAVVAALLEEAAAAGLSSVAVTFDRNPLSLINPDRCPASLVSNEQKLGLLADAGVDAALLLRFDQTLAQLTPEEFVTSILVGALHAKTVLVGEDFRFGHRGLGTVATLESFGEVYGFSVRVVDDVRPGGGRRVSSTWIRELLEEGDVREASRLLGRPPGVRGVVVHGAKRGRELGFPTANLSPDSQGLIPADGVYAGWLFWRGRRYPAAISVGNNPTFDGVPQKQVEAYVLDETDLDLYDDEVEVQFVERIRGMVAFTGIEPLIVQMTDDVERARRMLS
>NZ_CP040750.1|WP_138944637.1|240776_242006_-|MFS-transporter
MGPRPLWRGRALALVGIVLVAANLRTAVTSLSPIFAEIDGDIGVGSVGLGLLGMLPPLCFALFGVFTPRLVRRLHLEPVLLIALGSIVAGHLMRSLAPDFAVLAIGSALCFAGIGIGNVMLPPLVKKYFPDRVGLVTSLYATVLSVSTFIPPLIAVPVADAAGWQVSLGVWSIVAMLAVLPWITLIVRERRDARAAAATEPEIEEVPRAGRVLVHRSPIAWAIAAVFATSSLNAYAMFTWLPTIVGDVAGVTPAQGGLLLSLFSAMGVPASLIVPMLVARLRNVAVLVYVASACFVLGYLGLLLWPATLTWLWVLLAGLGPLLFPLALVLINLRTATHEGAVALSGFVQSVGYTLGALGPLVVSLLHAVTGSWTVPLLLLLATGALCAIAGRITGRPTTIEADLAARGR
>NZ_CP040750.1|WP_083397443.1|239628_240630_-|sugar-binding-transcriptional-regulator
MIESDELLAVRAAELYYDETKTQDEIGALLGITRWKVGRLLAQARELGYIRIEIVHPRARRLPLERALRERFGLADAVVVPSPSDSADLHERVARAAADYLGAMRPVPRTLGVSWGRTLRDIADHLSDGWATGLSVVQINGGVSLNQRVGTAAATAARIAEKGRGDVTLLPSPAIFERLETKLSIESDRTVAEVLRTAAAADTYLYGAGVAGPDSALVHSGYLTAADVDVLVARGAVGDVVGRYIDAEGMIVDPTLDERTVGLGLEALRRAGRSIAVIAGAQKHAVARAVVSSGLCTVLVTDEATATALLADHEPSSAKQHTPEQELLGRNAP
>NZ_CP040750.1|WP_071262338.1|238609_239632_-|deoxyribose-phosphate-aldolase
MTTPPGDLVAKPTALELVDGPVTDASLRRYLDGLAGVDAVGLEQRAADLGTRSIKTTSKAWALDRIIELIDLTTLEGADTPGKVRSLVAKAITPDAGDPSTPRVAAVCVYGDMVPYAVEALGAAHTQPGAAHDAGGINVAAVATAFPSGRASLAVKLADTADAVDAGADEIDMVIDRGAFLSGRYGQVFDEIVAVKEACRRSDGTSAHLKVILETGELNTYDNVKRASWLAILAGGDFIKTSTGKVAPAATLPVTLLMLEVVRDWHRLTGEQIGVKPAGGIRSSKDAIKYLVTVAETVGEEWLQPHLFRFGASSLLNDVLLQRQKLTTGHYSGPDYVTID
>NZ_CP040750.1|WP_138944636.1|237106_238603_-|aldehyde-dehydrogenase-family-protein
MSFLEYAPAPESTSVLHLRSEYGLFIDGEFTEGTGGSFQTISPSTEQSIATISAASDADVDRAVTAARRAYDRVWSKLSGADRGKYLFRIARLVQERARELAVAESLDNGKPIKESRDVDVPLVAAWFFYYAGWADKLDYAGLGANPRALGVAGQVIPWNFPLLMLAWKVAPALAAGNTVVIKPAETTPLTALIFAEILQQAELPAGVVNIVTGAGATGAAIVRHPDVNKVAFTGSTAVGREIAKTIAGSDTRLTLELGGKAANIVFDDAPIDQAIEGIVNGIFFNQGHVCCAGSRLLVQESIHDEVVDRLKSRLQTLRVGDPLDKNTDVGAINSAEQLARIRELSDIGELEGAERWSPDCELPENGFWFAPTIFTNVSTSHRIAREEIFGPVLSVMSFRTPAEAIAKANNTPYGLSAGIWSDKGSRILAVADKLRAGVIWANTFNRFDPASPFGGYQESGYGREGGRHGLGAYLAPAGSSAAATVAPSTSTTKEEQR
>NZ_CP040750.1|WP_138944643.1|250123_250393_-|DUF448-domain-containing-protein
MEPVRTCVGCRRREPRSALLRVVAVEGALVPDAAARLPGRGSWVHPTSVCVDQAVQRRAFTRALRLSEGPDASAVQAFVSTEPAAPTAE
>NZ_CP040750.1|WP_079707160.1|250398_251400_-|transcription-termination/antitermination-protein-NusA
MDIDLGLLKSIEREKEIPFEELVVIIEQAILSAYLKSTEGTDTTARGDVPAARVQLDRKTGHVGVFVPEFDDEGVLIGEAESTPDDFGRIAAFAAKQVIFQRLRDIQDDAVLGEFKGREGDIIAGVIQQGPNPRMIHVDLGTIEAILPPEEQVAGEEYPHGARIRVYVTSVTKGLKGPQITVSRTHPGLVRKLFALEVPEIASGIVEIVSLAREAGHRTKIAVKANDPSINAKGACIGELGRRVRAVTDELGAEKIDIVDYSPDLPTFVANALSPAKVTSSYVIDQSLKAVRALVPDYQLSLAIGKEGQNARLAAKLTGAKIDIQPDSILESD
>NZ_CP040750.1|WP_138944644.1|251606_253316_+|HAMP-domain-containing-protein
MVLGELRNVMRSTRVRILVAILLATTLAMTLVGVSTYTLGRQQTLATIDARLEHSAELIAFMVVGSGDSADAPATSDAAVDAVMRRWIFAEDETAIGVRADGSTVAPSAPSAFRLDDDPQLLDTITARSSRGVVTGEATGDRTVRYAIIPVQVVGDPSVAHVVIATDVHAALAESRGILAVEIVVAVVCLLLLGLVGWQLAGGLLHPIRLLRDAAARITESDLDERIPVVGRDDVSELTTTVNGMLDRLDEAFTSQRQLLDDVGHELKTPLTIVRGHLELLDPSDPAEVAATRDLALDELDRMSSLVADITELSTAGLASTLDREPVDIEAFTASVHEKATAISTEHEWTLGEQAALTADVDAGRLAQAWLQLADNAAKYSPAGSTIVISSRFDESDDPALVLSVADDGPGVPEALRERIFDRFTRVSGGRGVAGSGLGLSIVQAIAAAHGGWAEVEDTQETGSLFSIRLPLAVADDDDGSDADLDLDPDETAAIPRSAMAQAIALREAQAAQEAAEAQTSAAMQAGPTPGDARPAIDASPHSRAPSPEDDFPDLVDTSARRSAPEDHA
>NZ_CP040750.1|WP_138944645.1|253312_253993_+|response-regulator
MSRILVAEDETRISAFVSKGLRAAGHTADVTVDGSQVVELAESGDFDLLVLDIGLPGVDGFEVLRRLRDDGSELPVIILTARDSARDLVAGLDGGANDYMSKPFRFEELLARIRRRLAERGPASTAAVQERLSVGHLELELRERRVLVDGVPVELSTREFALAEEFFRHPDQILSREELLSRVWGYDFDPGSNVVDVYVRYLRNKIGKDAIATVRGAGYRLSTRAQ
>NZ_CP040750.1|WP_138944646.1|254092_255019_+|hypothetical-protein
MRPPRPLPTHLVGRAFTTDDVGLHGQSIGRLRGRDLSAPHRGVRTVGVDLDTVRGRCRAYEPLLGRSRVFSHVTAALLLDLPLPPRVASAPELHVGARDGTTPPRARGIVGHRLAPDTVVAFAHGHPVTAALDTWRSLADVLPQEELVAVGDRIVSGVRTGTDRTDVLASVADLRQAALEHRGRRGAAALRWAAARVRTGVDSRPESLLRLAVVEAGLPEPLVGHPVVVDHGGLTLHPDLADTRARLLYEYEGDFHRTERHRFRDDIHRRELLEDAGWRVIRVTADDLFARRQQFIRRIRHLHAARAQ
>NZ_CP040750.1|WP_138944647.1|255066_256824_-|proline--tRNA-ligase
MVTRLSNYFLRTLREDPSDAEVTSHRLLVRAGYIRRQAPGVFAWLPLGLRVKNKIEAIVREEMANAGAFEVHFPALLPREPYEVTGRWEEYGDALFRLHDRKGADYLLAPTHEEVFTLLVKDLYSSYKDLPLSIYQIQDKYRDEARPRAGLLRGREFTMKDAYSFDVSDAGLDASYQAQRDAYERIFTRLGLEYEIVQADAGAMGGSRSEEFLHPTAVGEDTFVRSAGGYAANVEAYATEVPEARPIEGLAPATVFDSPNTPTISTLVDLANERHPRDDGRAWTAADTLKNVVLALRHLDGTRELVVIGLPGDRDVDLKRVEVAFSPAEVEAATEADFAANAGLVKGYIGPWSPQGPVLGEESATEIRYFLDPRVVDGTEWITGANVDQQHVFGLVAGRDFTADGFVEAAEVRAGDPAPDGSGPVELARGMEIGHVFQLGRKYAEALGLKVLDENGKLVTVTMGSYGIGITRILAIIAEGNNDERGLIWPKAVAPFDVHVVAAGRDAAIFEVAEELVASLEASGKDVLYDDRTGKVSPGVKFGDAELIGVPVVVVVGREATEGFVELWDRAAGTKDRVAIADLAL
>NZ_CP040750.1|WP_138944649.1|258037_259078_-|VWA-domain-containing-protein
MTINPVLPIWAVAVLGTVLAAFAVWQFLAGARRPGAWHWIARLAMVVVLVIIALRPTIPGNHRPPSAMGDLDVYFVVDTTSSMAAEDWPDETASGTDENGAPKPPTRLDGAKADITGIADRLAGARYALVTFDAVAVQRMPLTTDATALRSAAEAMTQEITTYSRGSSIDAPVEFMTTLLTQAEEQEPGRNRIMFYLGDGEQTSGAAPGSFESIAPLIGGGGVLGYGTEAGGTMREFSGYQDGSVRYIQDYSTGEPAVSRLDPGALETIASQLGVEAEIRTPGASLDDALDGLAVGGVTVEDEVDIRRTDELYWVFALGFGVLLLTELPGLVGALGELRRTKGGQA
>NZ_CP040750.1|WP_138944650.1|259074_260073_-|VWA-domain-containing-protein
MELIYWWMPLVWLLAVAAVVAAVVLVARTGRRRKANAEPLWVAHSERLTALPGYRRALSRYRRLIIATIAALGVLLLAGMALGSRVVSTTVFQPELRNRDIVLCLDVSGSMTEYDAALVGVFEKLVQRFDGERIALVLFNASATTYFPLTSDYDYVAAQLDHLVEDLTSPESDYEYWNGTDLGNGSSLIGDGLGSCVMRFDQVGEERSRSIVLATDNYVAGEPILTLKEAGAYAKAQDVTVYGINPGDVSSKDYLDDLAAEMDEVVTSTGGDYYALADPGAVGGIVQQITAEQTKTLKGAKQLVQVDEPFVFVLAAFGGLAALMLLAWRLRR
>NZ_CP040750.1|WP_138944651.1|260063_260531_-|hypothetical-protein
MPGDNGYYAPVQYTLLWPVLGLVLIALVIGWYVWMLAHVRRRARGSAPRPAPQPSPTVLRDRYLALIGEIEREHGDGALSTRRAHQRLGAILRMYAHESSGVRAQVMTLADLDRAGLAPLSRAVSAYYPVEFREAETGSVAEAASLARQVVTTWS
>NZ_CP040750.1|WP_138944652.1|260517_261444_-|DUF58-domain-containing-protein
MPSSERSRHRRPVSAPLLHRVKSKLFIHAHRRVRGMLDGEYRSVFQGRSLDFDDLREYTPGDEIKDIDWKATARHGAPLVKRFIATRKHQVLFVVDTGRDLAALAEGGSTKREVAILAVGILGYLAIRHGDLVGLVAGDAAAPELVRPAGTESALERLLQHIDRRASLAAPQSDLDELLGYAARSVKQRCLLVIVSDDEEITPKRSEILRRLHVQHEVLWISVGDADLMRAEYTGRAMVDVADERSLPAFIRSDDALRREFTEAVTSATARLLDQLEELGISGQRVTGADDVVPVLFHLLEAHRHARR

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Crispr_ID: NZ_CP040750_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_3

611592-611704

Orphan

Consensus_repeat	Method
CCGCCCTTCGACAAGCTCAGGGACCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_3

>merge|NZ_CP040750|3|611592-611704|CRISPRCasFinder
CCGCCCTTCGACAAGCTCAGGGACCGGGAGAGGTGCACCGGGACCGCCCTTCGACAAGCTCAGGGACCGGAAGAAATGCTCCGGGACCGCCCTTCGACAAGCTCAGGGACCGG

>NZ_CP040750|3|3|611592-611704|CRISPRCasFinder
CCGCCCTTCGACAAGCTCAGGGACCGG	GAGAGGTGCACCGGGACCGCCCTTCGACAAGCTCAGGGACCGGAAGAAATGCTCCGGGA
CCGCCCTTCGACAAGCTCAGGGACCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138944857.1\|611775_613548_-\|glycoside-hydrolase-family-3-protein	unknown	unknown	gnl\|CDD\|224389
NZ_CP040750.1\|WP_138944855.1\|609303_610380_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238571
NZ_CP040750.1\|WP_138944860.1\|615165_616362_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP040750.1\|WP_138944858.1\|613684_614638_-\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|369561
NZ_CP040750.1\|WP_138947176.1\|618272_619307_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182464
NZ_CP040750.1\|WP_138944851.1\|605264_605816_-\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|378444
NZ_CP040750.1\|WP_138944862.1\|620590_621241_-\|DUF2975-domain-containing-protein	unknown	unknown	gnl\|CDD\|378586
NZ_CP040750.1\|WP_138944849.1\|603131_604115_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224525
NZ_CP040750.1\|WP_138944853.1\|607160_608339_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP040750.1\|WP_138944848.1\|601446_602145_-\|nucleoside/nucleotide-kinase-family-protein	unknown	unknown	gnl\|CDD\|236442
NZ_CP040750.1\|WP_138944850.1\|604283_605225_-\|linear-amide-C-N-hydrolase	unknown	unknown	gnl\|CDD\|238885
NZ_CP040750.1\|WP_138947175.1\|617316_618255_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP040750.1\|WP_138944854.1\|608335_609178_-\|aldolase	unknown	unknown	gnl\|CDD\|224743
NZ_CP040750.1\|WP_138944852.1\|606434_606761_+\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198403
NZ_CP040750.1\|WP_138944859.1\|614678_615044_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133388
NZ_CP040750.1\|WP_064296395.1\|602366_603095_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|180817
NZ_CP040750.1\|WP_138944856.1\|610405_611428_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224525
NZ_CP040750.1\|WP_138947177.1\|619339_620332_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182463
NZ_CP040750.1\|WP_138944861.1\|616412_617264_+\|SIP-domain-containing-protein	unknown	unknown	gnl\|CDD\|99790
NZ_CP040750.1\|WP_079002926.1\|620351_620591_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|226181

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138944857.1\|611775_613548_-\|glycoside-hydrolase-family-3-protein	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	1.10234e-48
NZ_CP040750.1\|WP_138944855.1\|609303_610380_+\|hypothetical-protein	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	9.14906e-21
NZ_CP040750.1\|WP_138944860.1\|615165_616362_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	5.02227e-50
NZ_CP040750.1\|WP_138944858.1\|613684_614638_-\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	6.54291e-27
NZ_CP040750.1\|WP_138947176.1\|618272_619307_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	4.01955e-89
NZ_CP040750.1\|WP_138944851.1\|605264_605816_-\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|378444	pfam10544, T5orf172, T5orf172 domain. This domain was identified by Iyer and colleagues.	0.00297081
NZ_CP040750.1\|WP_138944862.1\|620590_621241_-\|DUF2975-domain-containing-protein	gnl\|CDD\|378586	pfam11188, DUF2975, Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	0.00292126
NZ_CP040750.1\|WP_138944849.1\|603131_604115_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.69169e-92
NZ_CP040750.1\|WP_138944853.1\|607160_608339_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.27739e-24
NZ_CP040750.1\|WP_138944848.1\|601446_602145_-\|nucleoside/nucleotide-kinase-family-protein	gnl\|CDD\|236442	PRK09270, PRK09270, nucleoside triphosphate hydrolase domain-containing protein; Reviewed.	6.52615e-85
NZ_CP040750.1\|WP_138944850.1\|604283_605225_-\|linear-amide-C-N-hydrolase	gnl\|CDD\|238885	cd01902, Ntn_CGH, Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that inhabit the gut. CGH has an N-terminal nucleophilic cysteine, as do other members of the Ntn hydrolase family to which CGH belongs.	4.52783e-105
NZ_CP040750.1\|WP_138947175.1\|617316_618255_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	3.96924e-55
NZ_CP040750.1\|WP_138944854.1\|608335_609178_-\|aldolase	gnl\|CDD\|224743	COG1830, FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism].	6.24563e-64
NZ_CP040750.1\|WP_138944852.1\|606434_606761_+\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198403	cd10456, GIY-YIG_UPF0213, The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1. This family contains a group of uncharacterized proteins found mainly in bacteria and several in dsDNA viruses. Although their function roles have not been recognized, these proteins show significant sequence similarities with the N-terminal GIY-YIG endonuclease domain of structure-specific endonuclease subunit SLX1, which binds another structure-specific endonuclease subunit SLX4 to form an active heterodimeric SLX1-SLX4 complex. This complex functions as a 5' flap endonuclease in yeast, and has also been identified as a Holliday junction resolvase in human.	6.3035e-31
NZ_CP040750.1\|WP_138944859.1\|614678_615044_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133388	cd01282, HTH_MerR-like_sg3, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 3). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	8.19945e-38
NZ_CP040750.1\|WP_064296395.1\|602366_603095_+\|SDR-family-oxidoreductase	gnl\|CDD\|180817	PRK07060, PRK07060, short chain dehydrogenase; Provisional.	2.45582e-91
NZ_CP040750.1\|WP_138944856.1\|610405_611428_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.27013e-83
NZ_CP040750.1\|WP_138947177.1\|619339_620332_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182463	PRK10440, PRK10440, iron-enterobactin ABC transporter permease.	2.42506e-93
NZ_CP040750.1\|WP_138944861.1\|616412_617264_+\|SIP-domain-containing-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.05998e-51
NZ_CP040750.1\|WP_079002926.1\|620351_620591_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|226181	COG3655, COG3655, Predicted transcriptional regulator [Transcription].	2.91002e-19

>NZ_CP040750.1|WP_138944856.1|610405_611428_+|substrate-binding-domain-containing-protein
MRSSRPPTMNDVAAAAGVGLKTVSRYVNGATNINQELSERIGAAIEALGYRHNLAAASIRPGRSSKVIGLIISDLANPYYSVLARSVERVCTEHGYLLMSASSEEDADRHRLLVDRLVAQRVDGLVVVPPRQATTAWATSTIVHVPMVLVDRPTGPLESVEVHTVLADNAGGATRATAAMLAAGARRVAFLGDSLELYTMRERLAGYHRALAEADLGGATGTGPIEPIVSDGAHSVEDAAAVVAGFLASGEVDAVFAANNRAAIGAMQAFATAGRRLPLVGFDDFEAAPLVTPAVSVVAQDVALMGRVAAETLLALIAGEAGPPVTHTLDVRLELRGSER
>NZ_CP040750.1|WP_138944855.1|609303_610380_+|hypothetical-protein
MGEIVVAGHICVDLSPGLSASARIDPGALIDTGPLRISLGGCVANTGLALADLGSTVRLHATVGDDELGAIVASRIAAHDRLHPALEVTNRAATSYSVVVEPAGLDRTFWHHTGANEVFTGEHLAVGDADLVHLGYPPLLPGIVADDAAPLAKLLERIHRHGATTSMDLAVVDPTSAVGRLDWEAILRRTLPLTDVVSPSVDDLRSALGTLRLPAGTSASPLAQAAAFADLLLAWGAGVVGISAGEDGLLLRAAGVDRLRSGGRMLAPLAEAWADVDLVAPPVPAPAFVSTNGAGDASTAGLLFAMSRGAAPAEAAELAGASAAATIAGRRPTAAVITRLRPGLSGLFGVAGADEPVA
>NZ_CP040750.1|WP_138944854.1|608335_609178_-|aldolase
MSLYRLNRLFNARSGRALDVAVDHGFFGERSFITGIEDMGEVVRTLVAAGPDAVQLTLGQARLLQQVPGKDKPALVLRTDVANVYGNPLDSILYSHHVPHAIEEAVRLDAVAVCVNLMQIPEHPEVREANIRSIMALRREATRYGMPLMIEPLVMQDNTTAGGYQVDGDIEKIVTLVRQAVELGADLIKADPSSDITEYARVVQVAGDIPVLVRGGGRVDDRTLLERTVAVLDAGVSGIVYGRNIIQHEHPAAITAALMAVLHDGADADAGLAILEAARA
>NZ_CP040750.1|WP_138944853.1|607160_608339_-|Gfo/Idh/MocA-family-oxidoreductase
MSGDQVTADRATAERVNVAIIGGGLMGREIAAAIQRWPALIDHPVRPRLTAVCDINPAALDWFDEIDTVVTKTTDYHELLADPSVDVVYVAVRHDLHEQIYTDVIRAGKGLLAEKPFGIDAAAAQSVLAAMAEHPESFVRCSSEMPFFPGAQLAIEYVRSGALGTIVEARNSFLHSSDIDRDKQINWKRQTQFCGEAGVMNDLGMHTWHVPLRLGWAPESVYGVLQNIVTERPGPDGSLVPCDTWDNAVLHSWATHDGVRFPLTTETKRIDPGQKNTWEFEAIGLDGGVRFSTKNPKLVEVFAVRDIPGVGREQVWQQLDAGSQSVWPTVTGPNFESGFSDTILQMWAVFLAERHGSLGDRFGAARPEEAALTHDIYRAAIRSHEEGRAIAL
>NZ_CP040750.1|WP_138944852.1|606434_606761_+|GIY-YIG-nuclease-family-protein
MPHVYILKCADGSFYTGSTIDLARRVAEHMDGLGATYTRERLPVTLVWSAEYDRVDDAFFIEKRLQGWSRAKKQAVIDGRFDDLPRLSCSRITAWRDPEPGSTPVAGP
>NZ_CP040750.1|WP_138944851.1|605264_605816_-|GIY-YIG-nuclease-family-protein
MPHRRCVQPGCDAVAPVDAPVALCEDHLALAADWAEQRWGVVDALPSPCIMCGSRLGRRYPTAWLCAACEWRQGDVPDDDLARPRIDVVYYLRHGDRVKIGTTTNPRQRFAAIWHDELLALERGDRHVERARHEQFARERLERSEWFTGSPRLLAHVASVARDVDPWDCYSRWLSEAAALRGR
>NZ_CP040750.1|WP_138944850.1|604283_605225_-|linear-amide-C-N-hydrolase
MCTRIFWNDNAVAKTVSRCMDWSESDEPELWFVPSGTDRGGTGDATSHRWTSRYGSVVTSMWGMGTVDGLNTAGLGAHALYLDPEDVTFAEPDGRPTVSNALWVQYLLDTYGSVAEAVADIDTVRITSPMFRGLQMGIHIALEDASGDSAIIEPIDGRLVVHHGREYTVMANSPSLDEQITNRDRYRPFGGELPPPGDITSVDRFVRASYFLHYLPEPADTVEAVAGVFQLIANVSVPYGAPYSTGDVYPTWWRAGADLTNRVYYFGSTRSPNIFWIELDELADVGEVRRLDPRDPSRVGDQTAELAPVTLSY
>NZ_CP040750.1|WP_138944849.1|603131_604115_+|substrate-binding-domain-containing-protein
MATMRQIAAAAGVSAKTVSRVFNDDPHVLPATRERVESIMRELDYVPNSLATAFRSGRPSVIGVAVPDIVDPFFAEIARAVERTARDHDMSTLVTSLGDDPDRERAVLEPMLRRQLAGVVLAPISDDQSSLSAWASRTPFVFVDRAPGGLAADAFTQDDFGGAFAATSHLVEHGHRRIGFVGDELALPTTAERLRGYRAALTEAGLPADEEIIALGAATREGAARALAAVDSRATALFSSNAVCTMALLPALAEQPLPLVAFGDFPLAELLRPSVSVITQDPEALGRLAAERIIDRLDRPDARYRRSTVLPVHLVERDSCRSAPAVV
>NZ_CP040750.1|WP_064296395.1|602366_603095_+|SDR-family-oxidoreductase
MTDFNGRTILVTGASGGIGGATVRHLVAAGAQVIASGRNVEHLDAIAAETGAEPLPFDLTSEDSIRDAIEGRDIWGVVNSGGWGGEIASPQETDIDVFDKVISINARGSLLVTKYASREMIRQERGGAIVNVSSQASLVALSGHISYGSSKAALDNITRVSALELGKYGIRVNAVNPTVVMTPMSAWYWGRPDIEGPFLEAMPLGKWATEDDIAGPITFLLSDAAGMISGVSLPIDGGYTAR
>NZ_CP040750.1|WP_138944848.1|601446_602145_-|nucleoside/nucleotide-kinase-family-protein
MSGTTTTAGTGLDGLIDHARSLAATGSRRILGIVGAPGAGKSTVSDAIAAALGDQAVIVGMDGFHLDNAELVRLGRRDRKGAPDTFDVDGYIALLSRLARAGRTAESPGTPIYAPRFDRSLEASIGSAVLVRPEVPLVITEGNYLLFDDHGWQGVAAHLDESWYVDVDDEVRRDRLIARRLGHGHPRDEAEAWVLGVDEPNARLVDATKQRATRIVTLDASTLVESESTHGT
>NZ_CP040750.1|WP_138944857.1|611775_613548_-|glycoside-hydrolase-family-3-protein
MSEHEPALPYRDASLPVEDRVEDLLGRMTVAEKAGMLFQTMIAPGPIDEANPHMGLASGEHMIGEQLMSHFNVLGTAPDTTALAEWTNALQERASRTRLGIPVTLSTDPRNHFTDNVGTAARAGAFSQWPETLGLAAIGSPDLVEAFADTARQEYLAVGIRLALHPQVDLATEPRWSRIGGTFGEDAELSAELVAGYIRGFQGAELGPQSVSTMTKHFPGGGPQLDGEDPHFAYGREQVYPGDNFDYHLIPFRVAIAAGAAQMMPYYGMPVGTGHEEVAFAFNHGIITGLLREELGFAGIVCTDWGLVTDTSIMGQDMPARAWGLEHLDELSRVERILQAGCDQFGGEARPELVVELVEQGRVTEDRIDASVRRLLREKFLLGLFEQPYVDAGAASGIVGRADFVAAGEAAQRRAFTVLTNVEETLPVRSPRPRLYLEGVDPEVAGAYGEVVADPASADVALVRMQTPYEPRPGGFEAMFHAGSLDIPADEVERLRALALTVPTVLDMHLDRPAILTGVADAVAALVASFGGSDAAFLDVVFGRALPEGRLPFDLPRSMAAVEASRSDVPYDTEDPLFRFGHGLTYPAGL
>NZ_CP040750.1|WP_138944858.1|613684_614638_-|alpha/beta-hydrolase-fold-domain-containing-protein
MSLDPYYRDRLSLFDGFSNADRAAAGGTLDEAFQERLAAYGDDGPWSPPSDVVITDEVVDGPHGAVPIRRYVPADPSGAALLWVHGGGFAAGTLDWPEAHVVSAELAARAGAEVVSVDYRLADGTTRYPVPLDDVLAVWEQLDDERSAVPGARTAIGGASAGAALALAASLRSDRRADAVLLAYPFLHAAVPALPADVLAEMAVLPDFMRFPTESIDWMVENYVGRLEDVPELALPGIVPVTPDRPPLSVLLSEFDDLRPSGELLIAASEAAGAPVRSRLEPGVLHGHLNRHPVAPGVSPSLDWLADGLRAMGNHAD
>NZ_CP040750.1|WP_138944859.1|614678_615044_-|MerR-family-transcriptional-regulator
MRIGELAAATGSTPRLLRYYEEQGLLRPTRCPNGYREYGDHLVAKVQRIRELIAVGMPTALILQVLPCFEDDDTIYQVTPSAEVLERLLEHRERLDAKLGCIQESRDAIDLYLHRVGGIVV
>NZ_CP040750.1|WP_138944860.1|615165_616362_+|MFS-transporter
MTTDSVRTARSTTPPAARTRPPVPTALLLAAVGFVTLLTEVLPAGVLPAMAADLGVSESIAGQSVAVFALGCIVAAIPLSRALAKLDRRTVVLLALIVSALANAGAAVAPDLLTHLATRFVAGLVAGVVWAILPGYTRGFTTPERFGSTLGVVLSGATLGFALGVPAGAVLGEGFGWRTVFGIVAAATALLGVLAVVVAPRVAGSAPGRSTRMGAALRIPAVVTILVALAVCIIGQNIAYTYLAPVLSSRGTPVPLGLLLATFGVASVVGTLGAGRLANLRLGTTIVTAALLGTVGLAVVAWDPPVVVLLIAAAGWGLAFGAYSVLFQVAIARVAGNTADAAQSALVTVWNCSIAIGGAVGGIILGTWGPALLLPAAAALTVVAIPLCAVIARAVRRG
>NZ_CP040750.1|WP_138944861.1|616412_617264_+|SIP-domain-containing-protein
MPVPFLHSPNILFDTVVDRTERLSPGFVRLTLAGASLADFAPYERDQRIKILLPGEDGAYPDGLHGGLPEHAWRRAWRALPPADRPVMRSYTAHRVRPALQEVDLDVFIHEPAGPASRWALAARPGDRLLVSGPDVRRGDPTHGVQWAPGTATTVLIAADETAFPAVHGILRSLDEDVRAHALLELGDPADTALLGPLLERHTVEVHERAGRAGGDALVAGVEQWLHLHGSSAATLGTDFAAWLVTESTRIPLLRAATTDHGIDPERVHGQGYWNARPRATPE
>NZ_CP040750.1|WP_138947175.1|617316_618255_+|ABC-transporter-substrate-binding-protein
MRAPPLAHRRRLVAVAALSIAALGLSACSSSSASTPSDTATSATHVMEHAHGETSIPDAPKRVVVLEPVQLDTTVALGITPVGAAVLNETAGVPAYLGEQAADIPTVGTVAEPNVQLIAAAKPDLIIGTESRHSALYDQLSEIAPTVFMATQTDPWRDNVQFVAEALGDPDGADELLDAYDARCAEIAKEHDTAGKTAQLIRPRDGVLTLYGPTSFAGSTLECAGFTTPEHAWEDISLDLSPERVLEAKADQVFVTSVDPDDTSTLPASLTANTDAFPELHLVDQSFWITGVGPLGGMAVLDDLDRLLSDGS
>NZ_CP040750.1|WP_138947176.1|618272_619307_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTARDTSVSGRAPQRHRLLLVLLAGVAVLAVAILLSLFVGANPIAPDDVRAALLGAGSDEADFVVWDQRVPRTVAALAVGAALGVAGALMQAFTRNPLADPGILGVNAGAGFAVAVGLAFLGVRAPGDIAWLACGGALVVTLVVYAIGSGGREQSSTARLTVTGVAFGAVLAGLTTGIAITHPDAFDRMRGWNAGSLLERDLGVVVPVLPFLVVGLVLAAASARSLNAIALGPDVARAQGVSVTRSRILVLAAVTLLAGGATAIAGPIAFVGLVVPHLVRWSVGSDQRRILGGSVLVGCVLVLCSDVVGRIAVLPGEMPVGLVTAFVGAPVLIALARRRTASGL
>NZ_CP040750.1|WP_138947177.1|619339_620332_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTGRRPAPRTLLVCAAVVLAIVVAAIAGLALGDYPLTTDEVIGVLTGRVDGLARTVVLDWRLPRVLAAIGFGAALGVSGAIFQTLTRNPLASPDIIGLANGSFTGMLVALLLLGGSWPALMAGSLIGGLAAAAAIFLLALRQGLSGFRFIVVGIGVSAMLAAFNSWLLLRADLDVALFAAAWGAGTLNTATATVVWPALACLVVLFAVLPLAARPLRQLELGDDVAAATGVRLTRERAILIGLAVALVSAVTAVAGPIAFIALAAPQIARRLTHSPGIPLVATGLIGGVVLLASDLVAQHLIPLTVPVGVVTVVVGGLYLTQLLLRERRR
>NZ_CP040750.1|WP_079002926.1|620351_620591_-|helix-turn-helix-domain-containing-protein
MVPTPEEDVATGVHCNLDRLLADRGLTLARLSELVGVSVVNLSVLKNDRAKAIRFSTLTAICRVLDCTVGELLELDDAR
>NZ_CP040750.1|WP_138944862.1|620590_621241_-|DUF2975-domain-containing-protein
MTESTDRPTPSGFDHAAWQAAKTQRSTRNDLVSVLGAAVVAAGAVVVTLVLRLLEIFGTDGTRVPVFFDAVDAVLPGAAGAGSFTIDQGSVVVADLPVVTFVCVLLAAILPAIANLLVIVCAFRFFRRLLRGDAFAPGNARLLSIASIAILCGWIADTWFGTMASNGALAAATDGAVEGTPYPLTWIPFFVAMAVGGLAIAFRAGERLRADTEGLV

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Crispr_ID: NZ_CP040750_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_4

646577-646660

Orphan

Consensus_repeat	Method
CGTGGGCACTTCGACAGGCTCAG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP040750_4

>merge|NZ_CP040750|4|646577-646660|CRISPRCasFinder
CGTGGGCACTTCGACAGGCTCAGTGACCGGGAAACGTACACCCGGAACGATGGGGCGTCCTCGTGGACACTTCGACAGGCTCAG

>NZ_CP040750|4|4|646577-646660|CRISPRCasFinder
CGTGGGCACTTCGACAGGCTCAG	TGACCGGGAAACGTACACCCGGAACGATGGGGCGTCCT
CGTGGACACTTCGACAGGCTCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138944874.1\|639017_640460_+\|glycoside-hydrolase-family-32-protein	unknown	unknown	gnl\|CDD\|350134
NZ_CP040750.1\|WP_138944878.1\|643802_644261_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319899
NZ_CP040750.1\|WP_138944875.1\|640542_642120_+\|glycoside-hydrolase-family-32-protein	unknown	unknown	gnl\|CDD\|214757
NZ_CP040750.1\|WP_138944887.1\|653411_654452_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380511
NZ_CP040750.1\|WP_079706939.1\|649288_650557_+\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NZ_CP040750.1\|WP_138944888.1\|654602_655985_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP040750.1\|WP_138944877.1\|642696_643704_-\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP040750.1\|WP_138944873.1\|637056_637971_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NZ_CP040750.1\|WP_138944881.1\|646729_647260_-\|DUF805-domain-containing-protein	unknown	unknown	gnl\|CDD\|377540
NZ_CP040750.1\|WP_086474331.1\|634773_636108_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|224567
NZ_CP040750.1\|WP_138944882.1\|647447_648791_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374201
NZ_CP040750.1\|WP_079706940.1\|648798_649110_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379642
NZ_CP040750.1\|WP_138944884.1\|651230_651722_-\|DUF4188-domain-containing-protein	unknown	unknown	gnl\|CDD\|316352
NZ_CP040750.1\|WP_138944879.1\|644349_644940_-\|DUF805-domain-containing-protein	unknown	unknown	gnl\|CDD\|377540
NZ_CP040750.1\|WP_138944876.1\|642155_642743_+\|DUF1349-domain-containing-protein	unknown	unknown	gnl\|CDD\|377771
NZ_CP040750.1\|WP_138944885.1\|651791_652424_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133407
NZ_CP040750.1\|WP_138947179.1\|636178_637060_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP040750.1\|WP_138944886.1\|652457_653375_-\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|238572
NZ_CP040750.1\|WP_138944880.1\|645271_646543_+\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP040750.1\|WP_138944883.1\|650603_651227_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138944874.1\|639017_640460_+\|glycoside-hydrolase-family-32-protein	gnl\|CDD\|350134	cd18622, GH32_Inu-like, glycoside hydrolase family 32 protein such as Aspergillus ficuum endo-inulinase (Inu2). This subfamily of glycosyl hydrolase family GH32 includes endo-inulinase (inu2, EC 3.2.1.7), exo-inulinase (Inu1, EC 3.2.1.80), invertase (EC 3.2.1.26), and levan fructotransferase (LftA, EC 4.2.2.16), among others. These enzymes cleave sucrose into fructose and glucose via beta-fructofuranosidase activity, producing invert sugar that is a mixture of dextrorotatory D-glucose and levorotatory D-fructose, thus named invertase (EC 3.2.1.26). These retaining enzymes (i.e. they retain the configuration at anomeric carbon atom of the substrate) catalyze hydrolysis in two steps involving a covalent glycosyl enzyme intermediate: an aspartate located close to the N-terminus acts as the catalytic nucleophile and a glutamate acts as the general acid/base; a conserved aspartate residue in the Arg-Asp-Pro (RDP) motif stabilizes the transition state. These enzymes are predicted to display a 5-fold beta-propeller fold as found for GH43 and CH68. The breakdown of sucrose is widely used as a carbon or energy source by bacteria, fungi, and plants. Invertase is used commercially in the confectionery industry, since fructose has a sweeter taste than sucrose and a lower tendency to crystallize. A common structural feature of all these enzymes is a 5-bladed beta-propeller domain, similar to GH43, that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	3.03026e-123
NZ_CP040750.1\|WP_138944878.1\|643802_644261_+\|VOC-family-protein	gnl\|CDD\|319899	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins. The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.	1.23424e-29
NZ_CP040750.1\|WP_138944875.1\|640542_642120_+\|glycoside-hydrolase-family-32-protein	gnl\|CDD\|214757	smart00640, Glyco_32, Glycosyl hydrolases family 32.	2.94963e-107
NZ_CP040750.1\|WP_138944887.1\|653411_654452_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|380511	cd06288, PBP1_sucrose_transcription_regulator, ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors. This group includes the ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.70461e-84
NZ_CP040750.1\|WP_079706939.1\|649288_650557_+\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	8.41778e-140
NZ_CP040750.1\|WP_138944888.1\|654602_655985_+\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.62222e-50
NZ_CP040750.1\|WP_138944877.1\|642696_643704_-\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	7.13294e-40
NZ_CP040750.1\|WP_138944873.1\|637056_637971_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.92302e-71
NZ_CP040750.1\|WP_138944881.1\|646729_647260_-\|DUF805-domain-containing-protein	gnl\|CDD\|377540	pfam05656, DUF805, Protein of unknown function (DUF805). This family consists of several bacterial proteins of unknown function.	7.23849e-21
NZ_CP040750.1\|WP_086474331.1\|634773_636108_+\|extracellular-solute-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	4.37972e-41
NZ_CP040750.1\|WP_138944882.1\|647447_648791_+\|hypothetical-protein	gnl\|CDD\|374201	pfam15892, BNR_4, BNR repeat-containing family member. BNR_4 is a family which carries the unique sequence motif SxDxGxTW which is so characteristic of the repeats of the BNR family, pfam02012. It is unclear whether or not this unit is repeated throughout the sequences of this family, but if it is then the family is likely to be bacterial neuraminidase.	3.6923e-06
NZ_CP040750.1\|WP_079706940.1\|648798_649110_-\|N-acetyltransferase	gnl\|CDD\|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	6.83835e-29
NZ_CP040750.1\|WP_138944884.1\|651230_651722_-\|DUF4188-domain-containing-protein	gnl\|CDD\|316352	pfam13826, DUF4188, Domain of unknown function (DUF4188).	7.86516e-49
NZ_CP040750.1\|WP_138944879.1\|644349_644940_-\|DUF805-domain-containing-protein	gnl\|CDD\|377540	pfam05656, DUF805, Protein of unknown function (DUF805). This family consists of several bacterial proteins of unknown function.	5.65027e-21
NZ_CP040750.1\|WP_138944876.1\|642155_642743_+\|DUF1349-domain-containing-protein	gnl\|CDD\|377771	pfam07081, DUF1349, Protein of unknown function (DUF1349). This family consists of several hypothetical bacterial proteins but contains one sequence from Saccharomyces cerevisiae. Members of this family are typically around 200 residues in length. The function of this family is unknown.	1.76194e-66
NZ_CP040750.1\|WP_138944885.1\|651791_652424_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133407	cd04780, HTH_MerR-like_sg5, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 5), N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.011e-20
NZ_CP040750.1\|WP_138947179.1\|636178_637060_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.00712e-72
NZ_CP040750.1\|WP_138944886.1\|652457_653375_-\|carbohydrate-kinase	gnl\|CDD\|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	2.58522e-64
NZ_CP040750.1\|WP_138944880.1\|645271_646543_+\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.95473e-19

>NZ_CP040750.1|WP_138944880.1|645271_646543_+|DUF222-domain-containing-protein
MTEATAAAICAGDEYAAQLAEFSDEWAELHRQQAALDAKKARLLARSAAYADAFADATVPAIFPPAERQGLSRRSTCAALAMATRTPERTIQRATNDAERLVNDAPAVLASLEAGRISARHAQVITDQLCDVPAAGRAAFLQAVLPVAERMTAAGLKSRARVLRERLHPESITARAVRSEADRRVEFEPAADGMAWVHLFTTAPIAQGIIERVEAAAAGSRNAGDTRTCAQLQADALAALALTGVTPEDVMSSPVLPHPIEVQEHIVPTVQITVPALAMAGVSDAPATLDGYGPIDPETAARIAVNAPSFTRILVQPETGAVLSVGRNQYRVPADLQRAVRLRDGTCRAPGCGRRARACDLDHSVAWEDGGTTDVGNLACLCRHHHRMKHLPGWNLDHGPGGVLKWTTPDGKHHRTEPDPAPF
>NZ_CP040750.1|WP_138944879.1|644349_644940_-|DUF805-domain-containing-protein
MSSNTTPEYPATPTYGQPYAPAPIRGAAPPDDLTLPLYGATFPQAIKRYLRKYATFTGRASRSEYWWATLFVFLVALIPNALLFTGVAIGASSAAAQREAVVFDSSTGSRTYYTQPGILEIPGAAPLILTGVVLLGLIGLATIVPNLALAWRRLHDANFPGPFYFLSLIPSIGGLILFVLFLLPSKPEGQRFDRVR
>NZ_CP040750.1|WP_138944878.1|643802_644261_+|VOC-family-protein
MSITTTTHLNFQGDARAALEFYQSVFGGRTTIASYSDFGMPKDAPGAELVVFGQVESEDGFRVMAYDSPGSTAGSLIGAGSTRREHGTTVTEQSCFVAVRGETLAEVETFWDRLVVGGSVVEQLAASAWSPGFGMVTDRFGVTWVLDVSAAN
>NZ_CP040750.1|WP_138944877.1|642696_643704_-|WYL-domain-containing-protein
MASPTSRLLQLLSLLQARRDWPGALLADRLDVSHRTIRRDVDRLREMGYRIEATMGPDGGYHLDAGSELPPLLFDDEQIVALTIALQTAAVAGSGFEEPALRALTTVRQVLPSRLRHRLDALDVTSVPRSGDGPTPQVAVPVLLALSAAIRAREVLRFGRSDDDPEPPRRVEPHHLVTSQGRWYLVAWDLDRDDWRIFRADRIVPRTPTGPRFRPRQVPGGDVQAFVAARFKGSEQTDAWPCVGTVVLHLPFDAVRPFMGDGTAEPLGPDRTRYTAGAWSWVALAASVNRFDTDVDVVEPPELAAAFAQLAERNAATVQTVSRGARRPADRDGRR
>NZ_CP040750.1|WP_138944876.1|642155_642743_+|DUF1349-domain-containing-protein
MDLQNLAEHGRWTTAPAAVTTEPDGSLLVTAVEGSDAWRHTSYGFVHDTEHALIAPMQRRAAIEVSFVLDGSEQFDQAGVFLRVSETTWIKAGVEVSDGVAQLGAVVTHGTSDWSVAPVPDWLGRTVTVRASRDGDAVTVRARVDGEAWRLVRVAHLDPETDVEAGLFCAAPTRAGLTVRFTAVRLGPPDDALHG
>NZ_CP040750.1|WP_138944875.1|640542_642120_+|glycoside-hydrolase-family-32-protein
MTHDLSRRTVLQGAGLGALALFASAGTPLAAQAATTTQAQASLRSVFHMTPPSGWLCDPQRPVFTNGAYQLYYLHSGQNNGPGGWDHATTTDGVAFTHHGTVMPLQPDFPVWSGSAVVDTANTAGFGAGAVIALATQPTDGVRKYQEQYLYWSTDGGFTFTMLPDPVIVNTDGRAAQTTAEIENAEWFRDPKVHWDAARNEWVCVIGRARYAAFYTSPDLTTWQLQHNFDFPNHDLGGIECPDLFQMRAGDGSWHWVLGASMDAYSIGLPMTYAYWTGTWDGTRFIADDLTPQWLDWGWDWYAAVTWPKAESPDDRRLAIAWMNNWKYAARDVPTDASDGYNGQNSVVRELRLEAQSGGRYSLLSSPVDALAGYATSTVSLPDQTVTGSAVLPWSGRAYEIELDLTWDTATNVGLSVGRSADGSRHTNIGKAGAELYVDRAPSDLAGFSLQPYTRAAAPIDAAARSVHLRVFVDTQSVEVFVNAGHTVVSQQVHFAEGDTGISLYTDGGPLTASGITIREFGTAI
>NZ_CP040750.1|WP_138944874.1|639017_640460_+|glycoside-hydrolase-family-32-protein
MHDEQHALPRPGFHLTPERNWMNDPNGLVFHRRRWHAFFQYNPEGGDWGNMSWGHASSIDLQHWDEHPVALRYTAEEQVYSGSVVAAGPDGRLTAYYTSVFTDGRQAQSRATSDDDGLTWQRDPENPILDRGSHAFRDPKIIRYEDAAGFRWIMLTVEAVERQVLVYSSTDLRTWELVSTVGPFGPTGVVWECPDLIPLAVDGRPDEVRWVLLLSTNPVGDAQDPDGSSMSYLLGDFDGTVFTPERAELQRLDHGRDFYAAVGFDGAPDGEAVILGWMGNWRYAADLPASPWRGAMSLPRRLSLTTVDGEPRLVQEPPAFVRERLAAIEPTTVVLSSDAVDLALEGDGVVELHWDPSITGELRLRLTADTDGAVLIAHDPAAASLAVTRSGGAMDTVHPDFASTSIVPLAGDRTARLLLSLDGPLLELFVDGGLATVSDLVLLGSGRPTLTLASERASPVSVAVIVLDRAPATDQVHALA
>NZ_CP040750.1|WP_138944873.1|637056_637971_+|ABC-transporter-permease-subunit
MTATLPARPTEHVAPPAAQAPKRKPRHTPRVRVQRTILTVTVVAIVLVQVYPLVWLLLTSFRTAADFAGGNPFALPSEWTLDNYARAFSTGNLGLNIVNSLIVTLGSSALIVIAGMMAAYALQVLGFRFSGLVRGLFLLGIIVPVQIALVPLFIDYSQVGLLDTHLSMIIPLAAFALPMAVYLFSSFYEYIPREMYEAASLDGAGPYRIFGQITFPLSVNTIITVVLVNSIFIWNDFIFANTFVLSDGLKTIPLGLQNYIGAMGNTDWTATFAAVCVTVTPLLLVFLVLNKAMISGLESGATKG
>NZ_CP040750.1|WP_138947179.1|636178_637060_+|ABC-transporter-permease-subunit
MLPRRSTLSVLVFLVPPLVLYGVAVLLPIVQSLFLSLFSWDGITDMAFVGLDNYVKMLTRDDVFWTSFGNALGYLAICLVLQLGGALLVAGLLTALPRARELVKTLYLLPAVISTVAIAILFQRLYALEPVGLINQLLAWVGLGDLQTAWLSNVQTVLAAVSIPEGWRFTGLYMLIIYAALMAVPRDLEEAARLDGASWWQIFWRIRFPYIRPVWITTTVMATTFALRGFDIPYLLTNGGPGQSSELLTTYMYKTAFVHTDYGYASAISMFIVVECLVAVGLIFLLLRRKDQS
>NZ_CP040750.1|WP_086474331.1|634773_636108_+|extracellular-solute-binding-protein
MRPTRGTAFVALVAAAALALSGCAGGSSATDPTDVDPKGDIVPREISWLLSRPADGGVITAMEQIADEYAKDHPGFSLNLITTPDRPSYIQKYETLAAANKLPELFDTDATPFAQKLAKQGRMVDVDLLLEDLGLADSYREAALNYQRFDDGSLYMVPFEFQLEFFWYNRSLLEDAGVTVPATLDDFPAMCKALRAKGVTPIALDGQDQWPLERYMAYYPFRMAGPEYIQDLKAGKASFSDPAGKAAAEWLYDLGQAGCFQEGFSSTGYADAQALFTSGKAAVYNIGTWELSNLATDALDPGVRDAVGTFTLPTIDGAVTADNEYVTPSGIGMAVNAKTYDPLVRDFLAFALERYPELYAATGALSPTTSAQTTVPANATELYASSVAQADGVGPAIAMPWDTQLDPATNTRLQQELTLLVQGDITPDEFITTMDAALTENVDD
>NZ_CP040750.1|WP_138944881.1|646729_647260_-|DUF805-domain-containing-protein
MSSDSSLGCASAPSGGRSAVKPPVPAAGVLPSPALPLPGATMSAAVGRFFRQYTTFSGRASRSEYWWTVLFLVLVWLIPTVLFGPGLAIAGIAAMQREPVVDDGSRLLSAALVIVGLLVAVTVLPSLAMLWRRLHDAGFPGPLFFLSAIPLIGCIVVFVLVLMPSRPSGRRFDRRR
>NZ_CP040750.1|WP_138944882.1|647447_648791_+|hypothetical-protein
MLRRHDTSTTPIVVNDNAAWCWFQDERALVDPVSNLLVVGSIASTGGIDGEQRGGNVEVTVVDLSTGTADVVVLHERLESDDHDVPALWRRRDGRWLAMYTRHKTDDLTRWRISEPHDPRRWGPEHTFDWSAHTGGLGVTYSNLHELDGRLYCFARAVNDDQCALVSDDDGDTWSYIGKLFTRPKVGYVNGYTRYVSSPGRIDLITTDHHPRDYDNSVYHGFLDADGLHRTDGAVVDPHPLRGDAPSQVELTTLVAAGSRMPDGGSWAGDLLSHCWTVDVRRAPDGTVAAVVSARADDGPAHPDEATERLRPVLDHRFLFARLTPGGSWQVHPLALAGPGLLPHEQDYTGLAAIDPDDLDSLYVSTPVDPRDDRPLAHHEIFHGRTDDDGATWTWTPVTEGSDVDNLRPIVAPGDPSTVSLLWFRGDMASSQDYRCEAVLLRLPRAE
>NZ_CP040750.1|WP_079706940.1|648798_649110_-|N-acetyltransferase
MSTSSTPEDGPQVVRNDERHEYEILVGERVAGIAGYREEPGRILFTHTEIDPDFGGQGLGSVLAAAALDDAVERGLTIVPYCPFIQAYLRKHPDFSGEVSWPE
>NZ_CP040750.1|WP_079706939.1|649288_650557_+|ammonium-transporter
MDQGNTAFILISAALVLLMTPGLAFFYGGLVKAKSVISMMMMSFGALGLIGVLWVLYGYAIAFPGSEGTVAPWAIDTGNIGLTAALETPEGAAYPPLAFVAFQATFAIITVALVSGAIADRAKFGSWMIFAGIWATVVYFPVASWVFNFGLADDGSFAYGGWITHGLQDVFGVGVIDFAGGTAVHINAGAAALALALVLGRRVGFKKGVHVPHNPPFVLLGAGLLWFGWFGFNAGSELAADGTAALVFVNTIAAPAAALLAWLVVEKIKDGKPTSVGAASGAVAGLVAITPACGSLHPIWAIVLGLVAGVVCALAIELKFKLGFDDSLDVVGIHLVGGLIGTLYLGFFANGTGLFMGGDASQLLVQAIAAFAVLIYSFVLAFIIGFAIEKTIGFRVKNEDEIAGIDTVVHGEEGYVLVDTKA
>NZ_CP040750.1|WP_138944883.1|650603_651227_+|hypothetical-protein
MRGAAGPEPAATPAHLVLVDVASRPPADPGPPRLVRFADLVRQPLDRGRGSVRDVWTSTDVDRRIRWRLQVVELRDAAGLIAAPDDMNHAIVGFAGPQVAVRAGGNELNGPGRILHRDEVLTVRESSVRLSRPRLRASGSSSMILLSYSTSEDPPTLNFEHPETAHDPADGLRITLALRGPIRRGEGEVPQGAALVSAPLAVPPRYR
>NZ_CP040750.1|WP_138944884.1|651230_651722_-|DUF4188-domain-containing-protein
MSRVVVGRITHRHEGELVVFHIGMTINQWWRVDKWLPIFGDMPRMLQELMSDPESGLLGSHILLGSSGPYLVQYWSSIDKLYAYASAPASAHRPAWSRFNKRARTAPKAVGVWHETFLVDRAESIYVSTPSMGLPAATEAVPVGSRQQHARQRFADGRTAGQR
>NZ_CP040750.1|WP_138944885.1|651791_652424_+|MerR-family-transcriptional-regulator
MRISELAAVSEVPVATIKYYLREQLLPEGERTSATQASYGDAHVSRLRVIRALLTAGVSIAETRNVVAALDSPPAGPYDLLGVAHTAVTPRPSGPVDTTRALELYERLGGVEAHCDPGLLAGLAGALDTLERAGFTVPPAVLDRYVDAARRIAEAEIDGIPADSPELAVQYIVLGTVLTEPLILALRRAAQQVVSSERFDGTEAPASQPS
>NZ_CP040750.1|WP_138944886.1|652457_653375_-|carbohydrate-kinase
MHAAPTTDVLIAGETLIDIVRRLDGTQAESPGGSPANVGITLGRLGRAPALVTHVGDDERGAAIRSWLDASAVTLVSAPTGRTSTAQATLDAEGAATYEFDLSLDLEASGAPDAAVVHTGSIASVLEPSADRLRELVEARRPSALITYDPNIRPSLIDDAARVRQAALDCIARAHVVKASDEDVAFLLPGVAPVDAAREWVAAGPGLVVVTMGGDGAVAVRDGSVLEIETPRVQVADTVGAGDTFMGALIDGLLTAGIAGPGAEERLREVSDEVLQQLLDRAAWAASITVSRPGANPPTSAELDA
>NZ_CP040750.1|WP_138944887.1|653411_654452_-|substrate-binding-domain-containing-protein
MSTQRRRTTLADVAERAGMSKAAVSMIMNDRPGSRLSADAVERVRAAAAELDYRPNPAAQVLRRGKTRTIGFISDEVTLTRHASGLIGGALEVSKAHDHTMLIAETEGIEGGLARAFETMIDHRVDGILIGLLGARLIDLPTTSTGVPVVVLNGASSSGHANVLPDERAAGYAVAKRLVDAGHRRIGVVGDLPQDVIDDPRQTATVALRFAGIAAAFAEAGIEPARVDIVEWQPEPGYEATAALLERHPDVTAILAANDGVAFGAYQVLLELGRRIPQDVSVVSFDDEILAGYLRPGLTTARLPYQEIGALGASMLLGQHALGHELVTMPIIERDSLIAAVSTDAG
>NZ_CP040750.1|WP_138944888.1|654602_655985_+|extracellular-solute-binding-protein
MVDLSRRAALALLGLGLAGTAISWPRLTGGDIPGRGDDALTVALFGTAQDAAARQSLVDGFQKLHPDIPVRIIAIQGQDWGNFFAKILTMVAAGTPPDIVSVATEGTQLFAERLAHPIDEYVQRDAAELQEYFDDVNPSLIESFMYKGNLFQLPDNFNAANMYYNTSAFERAGLERPRDDWSVDDFFTVGRTMQASAPGSFLPYFWNNRLWGGVVPWLYINDTSFLTEEKAPGGDWMWSKFYPNETPRGGGYLWENADALSDRTVESFEVLQRMVSEGIAANPAQGGGNELVSLFSRGSVGMTPAGGFWVKGLNDAGLGNDEYDVTYFPKMRGQRHQFGAGGYAMMQTSERKDEAWEWMKYCISVEGMSIAHSQPDSSLPRRSLNAELYGGDIGPKHWEVFYDTLDRFPTTGPMPAPPQQAAVESALIKNVVGTITNGPNGVRRGLETMQRDLELALKGR

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Crispr_ID: NZ_CP040750_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_5

872116-872211

Orphan

Consensus_repeat	Method
GACGGCTGCGTCGACGAGGCAGGCTCGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_5

>merge|NZ_CP040750|5|872116-872211|CRISPRCasFinder
GACGGCTGCGTCGACGAGGCAGGCTCGGGCGCGGACGCGGGCCCTTCGACAGGCTCAGGGACCGAGGACGGCTGCGTCGACGAAGCAGGCTCGGGC

>NZ_CP040750|5|5|872116-872211|CRISPRCasFinder
GACGGCTGCGTCGACGAGGCAGGCTCGGGC	GCGGACGCGGGCCCTTCGACAGGCTCAGGGACCGAG
GACGGCTGCGTCGACGAAGCAGGCTCGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138945031.1\|867444_868512_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NZ_CP040750.1\|WP_138945027.1\|863069_864380_-\|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|223936
NZ_CP040750.1\|WP_138945038.1\|890187_892230_-\|PTS-transporter-subunit-EIIA	unknown	unknown	gnl\|CDD\|182066
NZ_CP040750.1\|WP_138945035.1\|878530_880288_-\|beta-galactosidase	unknown	unknown	gnl\|CDD\|366567
NZ_CP040750.1\|WP_138945036.1\|880405_881758_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP040750.1\|WP_138945029.1\|865096_866563_-\|malate:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|377591
NZ_CP040750.1\|WP_138945032.1\|870123_870876_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|378940
NZ_CP040750.1\|WP_056014479.1\|871010_871610_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP040750.1\|WP_138945028.1\|864376_865024_-\|thymidine-kinase	unknown	unknown	gnl\|CDD\|235272
NZ_CP040750.1\|WP_138945026.1\|862656_863094_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_CP040750.1\|WP_064296092.1\|868624_869911_-\|aspartate-kinase	unknown	unknown	gnl\|CDD\|235843
NZ_CP040750.1\|WP_138945034.1\|874404_878388_-\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350146
NZ_CP040750.1\|WP_138945037.1\|885333_889242_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373145
NZ_CP040750.1\|WP_086475053.1\|883989_884979_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380488
NZ_CP040750.1\|WP_085512471.1\|881914_882865_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP040750.1\|WP_138945030.1\|866678_867410_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238141
NZ_CP040750.1\|WP_138945039.1\|892348_893350_-\|hexose-kinase	unknown	unknown	gnl\|CDD\|238570
NZ_CP040750.1\|WP_138945025.1\|860677_862477_-\|DUF4012-domain-containing-protein	unknown	unknown	gnl\|CDD\|379067
NZ_CP040750.1\|WP_064296050.1\|882864_883788_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP040750.1\|WP_056014456.1\|889838_890108_-\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|376329

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138945031.1\|867444_868512_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NZ_CP040750.1\|WP_138945027.1\|863069_864380_-\|nucleotide-sugar-dehydrogenase	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	6.44002e-175
NZ_CP040750.1\|WP_138945038.1\|890187_892230_-\|PTS-transporter-subunit-EIIA	gnl\|CDD\|182066	PRK09765, PRK09765, PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional.	1.22776e-121
NZ_CP040750.1\|WP_138945035.1\|878530_880288_-\|beta-galactosidase	gnl\|CDD\|366567	pfam01301, Glyco_hydro_35, Glycosyl hydrolases family 35.	5.71586e-149
NZ_CP040750.1\|WP_138945036.1\|880405_881758_-\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.99462e-64
NZ_CP040750.1\|WP_138945029.1\|865096_866563_-\|malate:quinone-oxidoreductase	gnl\|CDD\|377591	pfam06039, Mqo, Malate:quinone oxidoreductase (Mqo). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.	0
NZ_CP040750.1\|WP_138945032.1\|870123_870876_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|378940	pfam12746, GNAT_acetyltran, GNAT acetyltransferase. Many of the members are annotated s being Zwittermicin A resistance proteins, whereas others are listed as being GNAT acetyltransferases. The family has similarities to the GNAT acetyltransferase family.	1.14777e-07
NZ_CP040750.1\|WP_056014479.1\|871010_871610_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	3.02225e-120
NZ_CP040750.1\|WP_138945028.1\|864376_865024_-\|thymidine-kinase	gnl\|CDD\|235272	PRK04296, PRK04296, thymidine kinase; Provisional.	2.76335e-80
NZ_CP040750.1\|WP_138945026.1\|862656_863094_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	2.01779e-09
NZ_CP040750.1\|WP_064296092.1\|868624_869911_-\|aspartate-kinase	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	0
NZ_CP040750.1\|WP_138945034.1\|874404_878388_-\|family-43-glycosylhydrolase	gnl\|CDD\|350146	cd18825, GH43_CtGH43-like, Glycosyl hydrolase family 43 protein similar to Clostridium thermocellum exo-beta-1,3-galactanase CtGH43 and Ruminococcus champanellensis arabinanase Ara43A. This uncharacterized glycosyl hydrolase family 43 (GH43) subgroup belongs to a subgroup which includes characterized enzymes with exo-beta-1,3-galactanase (EC 3.2.1.145, also known as galactan 1,3-beta-galactosidase) activity such as Clostridium thermocellum (Ct1,3Gal43A or CtGH43) and Phanerochaete chrysosporium 1,3Gal43A (Pc1, 3Gal43A), and arabinanase (EC 3.2.1.99) activity such as Ruminococcus champanellensis Ara43A. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	3.84068e-126
NZ_CP040750.1\|WP_138945037.1\|885333_889242_+\|hypothetical-protein	gnl\|CDD\|373145	pfam14587, Glyco_hydr_30_2, O-Glycosyl hydrolase family 30.	2.58644e-18
NZ_CP040750.1\|WP_086475053.1\|883989_884979_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380488	cd01574, PBP1_LacI, ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of LacI is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	9.94848e-109
NZ_CP040750.1\|WP_085512471.1\|881914_882865_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.34458e-69
NZ_CP040750.1\|WP_138945030.1\|866678_867410_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238141	cd00229, SGNH_hydrolase, SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.	9.13372e-16
NZ_CP040750.1\|WP_138945039.1\|892348_893350_-\|hexose-kinase	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	9.05363e-87
NZ_CP040750.1\|WP_138945025.1\|860677_862477_-\|DUF4012-domain-containing-protein	gnl\|CDD\|379067	pfam13196, DUF4012, Protein of unknown function (DUF4012). This is a family of uncharacterized proteins found in archaea and bacteria.	6.3791e-51
NZ_CP040750.1\|WP_064296050.1\|882864_883788_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.24412e-64
NZ_CP040750.1\|WP_056014456.1\|889838_890108_-\|HPr-family-phosphocarrier-protein	gnl\|CDD\|376329	pfam00381, PTS-HPr, PTS HPr component phosphorylation site.	3.37194e-23

>NZ_CP040750.1|WP_056014479.1|871010_871610_-|recombination-protein-RecR
MYEGIVQDLIDEFGRLPGIGPKSAQRIAFHILQTESFDVSKLAELLTVVREKVKFCEICGNISEQNLCSVCRDPRRNPALICVVEEPKDVVAIERTREFRGFYHVLGGAISPIDGVGPDDLNIRRLMQRLADGTVTEVIIATDPNLEGEATATYLSRLLLPMGIRITRLASGLPVGGDLEYADEVTLGRAFEGRTVVSG
>NZ_CP040750.1|WP_138945032.1|870123_870876_+|GNAT-family-N-acetyltransferase
MQQEDARVLATVRRLWQGLASPTARFSAGRVAVVVNAGSMACPPGWIGVVEIDGSALLIVPDEDTARRLAIEDESPRSVGTVEFLRSRVQVAEVLGPATLDYLLPGRFRPAEEIDVVASKASDPAIESLLSKVGDDEASESGIFGITSPLFSVREHGRVLAVAGYRSWPLGVAHVTALTAPEARGTGLATRLASTAVEHALAAGLLPQWRAADTNPGSRAVARKLGFSAIGRQLSARPVVAEWPAPSADA
>NZ_CP040750.1|WP_064296092.1|868624_869911_-|aspartate-kinase
MALIVQKFGGSSVADAESIKRVAKRIVETRKAGNEVVVAVSAMGDTTDELLDLAHEVTPIPAPRELDMLLSSGERISMALLAMAISSMGYVARSFTGSQAGMITDAQHGAARIVDVTPVRLREALDDGAIVIVAGFQGFNRDTRDITTLGRGGSDTTAVALAAALDADVCEIYTDVDGIFTSDPRVVPKARKIDRISSEEMLELAASGAKVLYIRAVEYARRHGVTLHVRSSFNNNEGTLVLNDAGRNNPGAGEAPMEQPIVAGVATDLSEAKITVVGVPDLPGKAAEIFTIVAKSGGNVDMIVQNVSTAVSGVTDISFTLPKPEAQQVLRALAAEQERVGFSAIQHDDQIGKLALVGAGMRTNTGVSAKLFEALSAAGINIEMISTSEIRISVVTRADTLNKAANVVHSAFGLDGEDEAVVHGGTGR
>NZ_CP040750.1|WP_138945031.1|867444_868512_-|aspartate-semialdehyde-dehydrogenase
MSNGVRVGVVGATGQVGKVMRRLLEEREFPISEIRFFATARSAGTTLPFRGQDIVVEDVETADPSGIDIALFSAGATGSRTQAPRFAAAGALVIDNSSAWRMDPEVPLVVSEVNPHAIKDAVKGIVANPNCTTMAAMPVLKVLDAEAGLTRLIVNTYQAVSGSGLAGAAELAGQIEAAVAQGDLTRLVHDGSAIDFPAPEKYVAPIAFDVIPLAGSIVDDGLGETDEEKKLRNESRKILELPELLVSGTCVRVPVFTGHSLSINAEFSRDLSPERAIELLSDAPGVQLSDVPTPLEAAGADPSFVGRIRPDQSAPAGKGLALFISNDNLRKGAALNAVQIAELVAAELLAQPATV
>NZ_CP040750.1|WP_138945030.1|866678_867410_-|SGNH/GDSL-hydrolase-family-protein
MARQRPRLRRRWLAAFIAAAIAVTAVITVSGLRADVQQTTVARADTSGSEVAVGPLVAFYGDSYTKGSAASSPAARWSSLVAKAEGWTEYNAGYPGLGFVRKRDKVGDVTADVIAQHPEVLIVALGINDNFEWTGNEQAIQEAILPEFQRLRDGLPGTRIIVVEPWWYTAERPASVEQIIGWVHDAADTIGADYISGASHWLDEDPATWISADGLHPSDAGYAHLAQRMLEELDALTPALPGR
>NZ_CP040750.1|WP_138945029.1|865096_866563_-|malate:quinone-oxidoreductase
MTETIDVALIGGGIMSATLAALIHQVQPDWKVEVYERLSDVALESSNPWNNAGTGHAALCELNYMPQDAHGQVDPAKAIGINEQFQLSRQFWSHLVEEGLLGAPDTFINPTPHMTFVRGDKDVEYLRKRYEALKDQPLFAGIEFSEDPAVIAEWAPLLINRRAVGERIAATRITAGTDVDFGSLTHKLFGAAPNAHVRTNHEVRSLKRLKDGTWRIRGRQTLGRSPMEINARFVFVGAGGWALKLLQKSGIPEIKGYGVFPIGGQFLRTDNPAVVSKHQAKVYSQASVGAPPMSVPHLDTRVVDGQASLLFGPYATFSPKFLKRGSMLDLVTQVRPHNLLPMLAVAKDNPSLITYLIGQLLQSRTQKMDSLREFLPTAKDEDWYLIEAGQRAQVMKKDKAKGGVLQFGTEVITGADGTIAGLLGASPGASTAVPIMLDVLRKCFPDRMTAWEPRLREMIPTYGSTLNDVPETAAKVLENTAEALDISL
>NZ_CP040750.1|WP_138945028.1|864376_865024_-|thymidine-kinase
MAKLYFRYGAMNSGKSTALLQAAFNYEERGHRVLLAKPSLDTKGDAAIVSRLGVTRDADFLLGPDDDAVRVFAEHRRRVVRETGEDVSCLLVDEAQFLHGEQVDDLLRIALLEGIPVLAYGIRTDFQTVAFPGSRRLLEVAHSLEELKTICRCGRKAIFNGRRFGDTFVFDGDQVAIDGTTVTYESLCGVCYLQESGGRLSSTPTAPPTSEGSHA
>NZ_CP040750.1|WP_138945027.1|863069_864380_-|nucleotide-sugar-dehydrogenase
MKLSVIGCGYLGAVHAAAMASIGHEVVGIDVDPAKIEALAAGRSPIFEPGLPELLLAGVESGRLRFSTDMADAAGATMHFVAVGTPQKAGSNAADLRYVDAAVTALLPHLSAGDVVVGKSTVPVGTAARLAELVAPTGAVLAWNPEFLREGFAVQDTIAPDRLVYGLPPAPEDAAVARAAFDEVYAQALSTGTPLVATGYSTAELVKVAANAFLATKISFINAMAEIAEVTDADVTELADAIGYDARIGRRFLNAGVGFGGGCLPKDIRAFTARAEELGRGESVAFLKEVDAINLRRRQRVIDLVVEELGGSAYQKRVAVLGLAFKPDSDDVRDSPALDVAVGLNGLGAKVLAFDPEAVPNARRLHPQLTFADSAEQAVTDADIVVVVTEWKAFRALDPSAVAELTAGKTIVDGRNCLDVDAWRGAGWRYVGLGRP
>NZ_CP040750.1|WP_138945026.1|862656_863094_+|VanZ-family-protein
MTRTPRIVIGILLLLCLSVMLGIAFWPTPVDADGRTTLLAILDRLQAAGAPTWFDYRFVESAANVVLFIPLGALLALELPLRLWWIAPLTTTLFSVAIELGQTLLPERVATIADVYANAAGGLLGATIVLVVRLLVTGHGRPRPT
>NZ_CP040750.1|WP_138945025.1|860677_862477_-|DUF4012-domain-containing-protein
MADPRPATAGIRLPGRRRSRLWWIALAVLLVVLALGAWLGVRASLAKNALEAAQSEAKSLQSAVLAGDASNTEATQRALTKHTGEAVSLTSDPIWRAAEAVPFLGVNFSAVRQAAAATDDVAVDVVPKVVEIADQVNLSSLLPGDGSIATEPLRAVAPTVAEAAAAADTIAGRVDTIGTDGALPVVADAVEKLTRTITGASTMLDTAARATALLPDMAGGAGPRNIMVMIQNNAELRSSGGIAGAVALIHAENGVISFVGTRGSDDFSGFPAPVLPLTPFEQNVYTENLGRYIQDTNLTVDFSRTGELAAAMGTQVFGVPIDTVVAVDPYVLAHLLEATGPVALPDGTELTADNAAKTLLSDVYARFPDRLVQDAFFAAVSGAVFEGMISRSPDPGALVQALSESGAENRLHVWSAVPAEQALIAQTSLAGIPPATDDAAVYTGVYLEDLTRAKMDYYLATKVDIRDARCTKQGAEYVVAVTLTSTAPADAATSLPDYVTAGGRFGTPAGDIATRVVIHGPLGATLLGASDGEDLPVKAVTDPNGRLYAQTDVTLTPGATRELVFTVLAPKASDVPPNLVTTPGITGKTTISAFPRCGS
>NZ_CP040750.1|WP_138945034.1|874404_878388_-|family-43-glycosylhydrolase
MRRATRRTDRSTPDGGAAVLRRGGLAAGLLTVAIVGTTALTAGSASAAEAPTAALLSWGDPAAPAELVGTPVTGVAAGLGHAVALGADGTVLAWGADGFGQATVPSLTGTITQVAAGTNHSLALAADGTVTAWGRDADGQATVPAGLDRVLRIAAGGPNSAAVRADGTLALWGDDAFGQNDLPTALDGARVTDVAIGSGFTVALTDDGDVVPWGRSDAGQLELPPALADEDVVQLAAGADHALALADDGTVLAWGADGSGQTEVPASLDGVDVVRVFAGPYLSGAIAADGSVTVWGADDARSALPDGLLAAGVALGETGAVAAAGAVPVAGGTNGGPGNTVESLPGGTDPGTGPGGEPGVNPGAGQPGSGTNAGGAGGLAVSGVSITAAVIVAAVLLLAGALLILRRRRVAASNSAEDASSSGGVGRSGVAGAVVLALGLSGALVTADAPRAEAAPSYPSPTVDELVANDFVLYFANAGSTVTDAVSAGDHIGLYQSRTDQSYGVDAATGASWGFVADANSNPTANSSSGTEKTASLRYDAPPAGSSLPTRSVDYAFDLPAGDYEVTLGFNLPSGWAARPLDLKAEGETLAQVTAPAGALLEQQLTVSVDDGTLDLEVHSPAGRTNTYTDPAVNYLVIRAPHTASTEVLAAKIRAVTLDEGQRAGYVADSLAVLDAAIADAQALVDAGSTDTAALTAAYDALGAALTALRPIVTYDSFRPGQAWVDDQGNPIQAHGGQVVPSTDADGQPIYYWYGEDRWNGYASSRGVHVYSSRDLYNWTDEGLALQALSTADQLTTDPAAAELYADYTAQQRAAVVRDLLTVPSDPAVPAAILERPKVMYNAATEQWVMWIHTDGPSATSDAQYAKATAGVAVSDSPTGPFRYVDSYRLNVAPEGEPNYQPDSPGMARDMNLFTDVDGTGYIIYASEENLTLFISKLSSNFMFLSAPVDRAVKGEDFTRTYIGGQREAPAVFVYDGTYYLITSGATGWNPNAAKYATAESMLGEWTDHGNPVTGSGASTTHGSQSTSVIPIDAAAGKFIYMGDRWTPSDLRNAPAVWLPLEFGDDGSLSLKWYDEWTLADLEGKGKVAVDVDVPATVRLGDASTLPSEAQVTEGGTTTTRAITWDTAALAVPGPVSLTGTVEGVSRPVTRQVTVVPKDLVYLVDAGGSASPEYDAIRSVADADGTLLNSTFDRTLGADAATGANWGVVGAETGTTDGPFSESLRYVASSATDRTLEYAFDSLDAGSYDVYVGLYDPWSQWADNRRADIGANGTTLLSAQPITGTPTVATLSSVQPDADGRLSITLDPVGSGGGTDVQLSWIMIVRR
>NZ_CP040750.1|WP_138945035.1|878530_880288_-|beta-galactosidase
MPTFSIGADDFLLDGQPFRILSGALHYFRVHPEQWADRIAKAKLMGLNTIETYVAWNQHSPERGVFDTTGVNDLERFLGLVADAGMYAIVRPGPYICAEWDNGGLPGWLLHDPELGLRRSEPRYLAAVREYFEALLPIVAPLQIDRGGPVILVQVENEYGAYGDDHDYLRTLTDWTRELGITVPLTTVDQPTAQMLEDGSIPELHKTGSFGSRSLERLATLREHQPTGPLMCSEFWDGWFDHWGEHHHTTPIAETAADLDALLAAGASVNIYMFHGGTNFGFTGGANDKGQYRSHVTSYDYDAPLDEAGHPTEKFFAFRDVIAKYAEVPTEIPPAATDAPAFTVSFEQEVPFADVADEIAPLQAFDRIPTMDELGAFSGLARYRASLGGRGGVLRFAEVRDRVVVSVDGVPVGALTREFKERSIVIPAGETLELLLENQGRVNYGKRLGEPKGIIGPVSLDSVELTSWGIAPVALDRLDAVVDAAATRTSGATISGAGPVLLTATVTLDAPTDLFLDTAAWGKGLVWVNGFLLGRYWSRGPQHTLYVPGGQLRAGENRFTVFEFHALTTPTLSFLARPSLGPTEF
>NZ_CP040750.1|WP_138945036.1|880405_881758_-|extracellular-solute-binding-protein
MKRISPSRTVLRRAATAAVASAMIGASLVACSSGGGSTASGDAKDIESALEAGGEITYWSWTPSAEAQVAAFEKAYPKVKVNLVNAGTNTTEYTKLQNAIKAGKGAPDVAQVEYYAIPQFALSDSLVDLNAYGFGDLKDDYSPGPWSSVNIGDGLYALPQDSGPMAMFYNKTVFDQYGIAVPTTWDEYIAAAAQLHTADPSKYITNDSGDSGFATSMIWQAGGRPFTADGTKVSVNLADEGSKKWADTWNQLVEGDLLSDVPGWSDDWYKSLGNGSIATLITGAWMPGVLESSVAEASGQWRVAPIPTYDGKPANAENGGGGQVVLKQSKNPALAAGFLKWLNNDEDSVKVFLDNGGFPATTADLNSDEFLSAAPEYFGGQKINEVLVQGAKDVSTGWQYLPYQVYANSIFADTVGQSYANKADLNDGLADWQKQLVEYGNTQGFTVTEK
>NZ_CP040750.1|WP_085512471.1|881914_882865_-|carbohydrate-ABC-transporter-permease
MATVSNPTVRPQTVSTRTARNPRAFDRPTRKRHDPRRKRSIVLTIVMAVFLIYSVVPILWLVINATKSQPDLFSSFGLWFGDGGFNLWQNIVDTLTYRDGQFVGWFGNTLLYVVVGAGGATLLATIGGYGLAKFRFPGKRAVFAIILGSIAVPGTALAVPTFLMFSQLGLTNTPWAVILPSLVSPFGLYLIWTYAVDAVPTELLEAARMDGAGEFRTFFTISLRLLGPGIVTVLLFAIVATWNNYFLPLIMLSEPTWYPLTVGLSQWSAQATGVAAQPIFNLVITGSLLTIVPIVIAFLFLQRFWQSGLSAGSVKG
>NZ_CP040750.1|WP_064296050.1|882864_883788_-|sugar-ABC-transporter-permease
MTTTTARTGRPPAVRVHRRDRRDWKGWAFIAPFMIVFALMIIAPLVYALYLSFFQEKLIGGNAFVGFENYAQVLQDPKFWEPFGRVALFFVVQVPIMLALSLTAALALDSARLHGAAFFRIALFLPYAVPGVVAALIWGFIYGDQFGLAGSFNDLVGAQILEPFSSQAVLASIGNIVTWEFMGYNMLIFYAALRVVPGEIYEAAEIDGAGQFRTVFSIKIPALRGALVIATIFSVIGSFQLFNEPNLLKNLAPNVITSNFTPNMYAYNLSFAGQQFNLAATVAIIMGVITAVIAYVVQVRGSRQENS
>NZ_CP040750.1|WP_086475053.1|883989_884979_+|LacI-family-DNA-binding-transcriptional-regulator
MADVAAHAGVSSQTVSRVANGLTNVDDGTRDRVLEAMTELGYRPNKAARALRSGRTRSIGITMFTLSSYGNMRTLDAITVQAARAGYSVTVVPVEYPTQRDVAVALDSLREQDVDGLIIVIESHIVDGADVELPAGLPVVVIDSAARTDYPVVDNDQAQGAALATQHLLDLGHQGVWHIAGPRTSYSAARREQSWADTLREAGITPPPAFRGDWSTTSGYEIGLEIAERPEITAVFASNDQMALGLLRALHERGRAVPESISVVGFDDTPESDSFWPPLTTVHQDFDEIGRRAITTLLREIEEGPQLSTEPLTPTSLVVRASTAPPPAR
>NZ_CP040750.1|WP_138945037.1|885333_889242_+|hypothetical-protein
MTLPSPVRRRTIGATVAVALGIAAIAPALATVEAAPAAAAESTPLTITPNPAYQNEAFEGWGTSLVWFANATGDYPADVRQDLFDKVFGEDGLNLNIARYNIGGGNASDVPPYLRAGGAVDGWWNPDLAASDADGPITSDYADRDRYAAAWDADDPASYDFDADETQRWWLTALKDKITKWEAFSNSPPYFMTESGYASGNFNAADEQLKPESVDDFVAYLTTVVDHLEADTGIDFDTIDPFNEPNTNYWGTTIDQSTGWPSGGRQEGAHIGPAMQDTVIKALAERLAAEGTSTDAVIAAMDETNPGIFATNWNGWSQTAKDLVTQLNVHSYGQGGSVVARDIAKTAGKPLWMSEVEGNWDSSGKHNLTNIDNGIGMATHLIDDLRNLEPTAWVLWQPVEDLYNMEKVEKLNWGSVLIDFDCNAEGGSERRIADGDADPSCSVKTNAKYNTLRNFTHYVQPGDHLIPSTDAQTTTALRADGTGATLVHANPSTSVRTITIDLSKFADIAPGATVTPIVTTESPADDVTANALVQGDAVSIDPVTKQATLTVPAKSVTTFLVDGATGVAADAAPFQDGHAYQLVGKQSAKAFTAAATTGTVPAGTITPRASDATTGAAQVWTAERLSGGGTNTDRYAVRSSSGALLSANSAGTSLVAATREQAAADPSLQWIPTTTNGSDWSLVNVGTSQALEVGGQSTTTGAAVGVYQSNNGANQTWSFVDTALTGVQPVTLQTVAGVPAALPTTVVPLYGAVQGAPVPVTWDTSAVDWNTPGTIVVNGSGTDGWGAAFTAQATVDIGGFTTTEPVSLTVAAGSPASAVIAAAPTTVPAQIGASTNRFDTPVTWDFSTLDDADLADTGVVQVRGAAASNDPAAAPIDAVLSIIVTAPGERNIAPDTTTVASATSTESGYPASNTKNGVRNDKGWSNWRSSNKPASDTLSYELGGQHTIEHVTFYAYKDGNTNSWPSALTVQVRDADGAWIDAPGGAVAVPVPTDGTAPIVDVDLGGVTTSAVRVVMTAYANTHLVVSEVEIYALAPSVATEASLAALRVNGTPVEGFDADVLEYEVPLAGSADPVVDAIPADRDATVTIEPLEAAPAAAARAAADASDGVVITVTAADGVTTQSTTITFARTAVATAMLSSVAREGVPTTAAVVVDPEDATVVYAWLLDDEVVDGADTATFTPPTGSAGAALAVRVTVSADGFAPVETTSTPVTVLAAAVDPGTDPGTDPGTNPGTGPGTGSGGGTAGGGDGTSSPSGGSAAGADSLSRTGVDVSSIGLVALLLGLVGFASVLLARRRRSAE
>NZ_CP040750.1|WP_056014456.1|889838_890108_-|HPr-family-phosphocarrier-protein
MAERQATIASRVGLHARPAKLFIETVKRQPVPVTIELGDSGPLDASSILTIMSLGATNGDVVTLRAEGEGADEALAELAGLLETDLDAE
>NZ_CP040750.1|WP_138945038.1|890187_892230_-|PTS-transporter-subunit-EIIA
MSTPLITPGLVALDADLGTDRAGVIRALAELVVRAGRATDTEALFADAWARESKTDTGIPGGIAIPHCRSAAVTEPTLAMARVSPLVDFGSDDGPADLLFFIAAPDGADQAHLALLSKLARSLIKPEFVTSLREAPDAAAVVALVEGALSDAPKPASAPAAERAATAPVEAGDQAARPVLIAVTSCATGIAHTYMAADSLAATAKRLGVELHVETQGASGATPLPADVVAKAQAVIFAVDVDVRDVTRFAGKPVIKAPVKRGIDAPEQLINDAVAAISNPNAPRVAAAAGDASASTSDKKDANVGQSIKRWLLTGVSYMIPFVAGGGLLIALGFLLGGYNITENAGKIIVENSLVNLPAGGLGAYLGAVAFSIGNASMAFLVPALAGYIAYAIADRPGIAPGFVAGAVALLMSAGFLGGLVGGLLAGGVAYGLGRLNVPRWLRGLMPVVIIPLIGSIVASGLMILVLGGPIAALMGGLNSWLSGLTGVSAILLGVILGTMMAFDLGGPVNKVAYSFAVAGLGAGTLANQAPWQIMAAVMAAGMVPPLAMALASTVLSRRSFTAVERENGKAAWLLGAAFISEGAIPFAAADLFRVIPASILGGAATGALIMATGVTSQAPHGGIFVFFAIGNIGMFILSVAVGTVITAIAVILLKRFARRRPVEGVDTAAPAVATAPATV
>NZ_CP040750.1|WP_138945039.1|892348_893350_-|hexose-kinase
MIITLTANPSLDHTVELPGVVERGEVLRALASREQPGGKGVNVSRAIAAAELATIAVLPGESTDPMIESLRAQGIDVLAVPTGQPVRRNITLTEPDGTTTKINEPGPLLTEDDAARLVDATARAAATAEWLVIAGSLPPGLPADFYARIVRAARALTDGTRPLVAVDSSGEPLAALLDAFAATGERVDLIKPNGAELAELTGTASGDEIEADPALAASVAATLIGTTDRPGPVAAVLVTLGSRGAVLVEGDTAWSARAPKIVARSTVGAGDSSLAGYLIARTAGLPPAARLAQAVAHGAAAAALPGSDVPALSGTDAAAIDVVQLPQRIPSAP

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Crispr_ID: NZ_CP040750_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_6

945524-945621

Orphan

Consensus_repeat	Method
TATCGGTCACTGAGCCTGTCGAAGTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_6

>merge|NZ_CP040750|6|945524-945621|CRISPRCasFinder
TATCGGTCACTGAGCCTGTCGAAGTGCACACGAGAAACCTTGCCCTCCGACAAGCTCAGGGAGCAGAGGGATATCGGTCACTGAGCCTGTCGAAGTGC

>NZ_CP040750|6|6|945524-945621|CRISPRCasFinder
TATCGGTCACTGAGCCTGTCGAAGTGC	ACACGAGAAACCTTGCCCTCCGACAAGCTCAGGGAGCAGAGGGA
TATCGGTCACTGAGCCTGTCGAAGTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_168223309.1\|951994_952261_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NZ_CP040750.1\|WP_138945076.1\|955769_957161_+\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP040750.1\|WP_138945069.1\|943667_945266_+\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|238038
NZ_CP040750.1\|WP_138945061.1\|933517_934621_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|223515
NZ_CP040750.1\|WP_138945077.1\|957147_959634_+\|transglutaminase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376628
NZ_CP040750.1\|WP_086475010.1\|954662_955706_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP040750.1\|WP_138945064.1\|937252_938479_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945066.1\|939833_940925_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224748
NZ_CP040750.1\|WP_138945073.1\|950855_951998_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237865
NZ_CP040750.1\|WP_064294959.1\|952725_953376_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NZ_CP040750.1\|WP_138945062.1\|934624_935884_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377422
NZ_CP040750.1\|WP_138945065.1\|938501_939728_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225153
NZ_CP040750.1\|WP_138945067.1\|941068_942835_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|293737
NZ_CP040750.1\|WP_138945072.1\|948469_950638_-\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|235537
NZ_CP040750.1\|WP_138945060.1\|932633_933530_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|224137
NZ_CP040750.1\|WP_138945070.1\|945787_946900_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945068.1\|943116_943470_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945063.1\|936149_937220_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
NZ_CP040750.1\|WP_138945075.1\|954039_954666_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378809
NZ_CP040750.1\|WP_138945071.1\|947233_948457_-\|acetate/propionate-family-kinase	unknown	unknown	gnl\|CDD\|234680

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_168223309.1\|951994_952261_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	0.00346329
NZ_CP040750.1\|WP_138945076.1\|955769_957161_+\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	2.6269e-24
NZ_CP040750.1\|WP_138945069.1\|943667_945266_+\|DUF222-domain-containing-protein	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	4.33297e-10
NZ_CP040750.1\|WP_138945061.1\|933517_934621_+\|glycosyltransferase	gnl\|CDD\|223515	COG0438, RfaG, Glycosyltransferase [Cell envelope biogenesis, outer membrane].	1.13797e-13
NZ_CP040750.1\|WP_086475010.1\|954662_955706_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.01961e-85
NZ_CP040750.1\|WP_138945066.1\|939833_940925_+\|acyltransferase-family-protein	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	2.24541e-42
NZ_CP040750.1\|WP_138945073.1\|950855_951998_+\|hypothetical-protein	gnl\|CDD\|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	6.37393e-07
NZ_CP040750.1\|WP_064294959.1\|952725_953376_+\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.21008e-50
NZ_CP040750.1\|WP_138945062.1\|934624_935884_-\|hypothetical-protein	gnl\|CDD\|377422	pfam04932, Wzy_C, O-Antigen ligase. This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.	0.000561779
NZ_CP040750.1\|WP_138945065.1\|938501_939728_+\|hypothetical-protein	gnl\|CDD\|225153	COG2244, RfbX, Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only].	2.49333e-08
NZ_CP040750.1\|WP_138945067.1\|941068_942835_+\|hypothetical-protein	gnl\|CDD\|293737	cd16013, AcpA, acid phosphatase A. Acid phosphatase A catalyzes the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at low pH. AcpA hydrolyzes a variety of substrates, including p-nitrophenylphosphate (pNPP), p-nitrophenylphosphorylcholine (pNPPC), peptides containing phosphotyrosine, inositol phosphates, AMP, ATP, fructose 1,6-bisphosphate, glucose and fructose 6-phosphates, NADP, and ribose 5-phosphate. AcpA is distinct from histidine ACPs and purple ACPs, as well as class A, B, and C bacterial nonspecific ACPs.	6.21531e-66
NZ_CP040750.1\|WP_138945072.1\|948469_950638_-\|phosphate-acetyltransferase	gnl\|CDD\|235537	PRK05632, PRK05632, phosphate acetyltransferase; Reviewed.	0
NZ_CP040750.1\|WP_138945060.1\|932633_933530_+\|glycosyltransferase	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	3.03739e-45
NZ_CP040750.1\|WP_138945077.1\|957147_959634_+\|transglutaminase-domain-containing-protein	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	3.64764e-24
NZ_CP040750.1\|WP_138945063.1\|936149_937220_+\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	6.21431e-19
NZ_CP040750.1\|WP_138945075.1\|954039_954666_+\|hypothetical-protein	gnl\|CDD\|378809	pfam12089, DUF3566, Transmembrane domain of unknown function (DUF3566). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 136 to 304 amino acids in length. This region represents a transmembrane region found at the C-terminus of the proteins.	0.00548489
NZ_CP040750.1\|WP_138945071.1\|947233_948457_-\|acetate/propionate-family-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0

>NZ_CP040750.1|WP_138945069.1|943667_945266_+|DUF222-domain-containing-protein
MSSSPRVPLGPVSADPLGTLGETVSELLRTWSGALDPIRPGDDAIEQLAGMNDAGVVRVLDQLGAVQHVVEVLAARVMGSVSERSRGGIVGHDPLARSHGYATPAVMLSERWRISRGRAATITSVAQAIAPKLALTGDVIECDRPEIAAAIEPRPAVDAPCLPLGEGDNPTCTVDHDEATSPSGFVRSALSVEGAGILLRELRLVKSGVDDERVHRSVSAGIEHCDGAPLAEVSSLAKLVRTGLDQDGPVPREIALRKQQRCTLRELPDGMTELRAFLAPEAAGWVRATMDAVVGKQLRQVRFVDPSDETAGAATASSELPSDDPFDDAYVPPAEMPDTRTMDERRVEALVGVFRHAAGCESAVMELAPVSLVIRMDEPDLADDGQWSDGKAYIDGVSEPISAGTARCMAADGRIIPMVLGGPSQVLDLGVGTRLFTKGQKMALAERDGGCAWTGCTHPPSYTEAHHLVWWSRGGPTDLSNGILLCSFHHHRIHNDGWEVLVRDHVPWFIPPAHIDPHRIPRRGGKPRLRAA
>NZ_CP040750.1|WP_138945068.1|943116_943470_-|hypothetical-protein
MRPLTVRERDLMVALIARGTEPGADRAIAASDRERWAGQLPGVMVHGTCGCGTCPSIDLTSDRGDRPTATRQTVLEASTSNAFLLLFIEDDRPTYLELAPFGDEPITEFPLVADVEF
>NZ_CP040750.1|WP_138945067.1|941068_942835_+|hypothetical-protein
MAHDEEPRPDTVHEAEPSPRPKRPTSRRDFFRAAGFGVAGLAAGGAVAGGIAAATASNPQEDYGFTPLPKRSEPGFDHVVVVMFENRSFDHMLGWLYPAGGEPAGQTFDGLAQGDYSNPGESGEAVPAHVYTGPTDQIMAQPDPDPGEFYPHVNTQLFGTIDPESNGDLRNPLQPPWNLPADTSSPKNDGFVKDYIVNSTLARGRKPTPEEYSTVMGGFSPEMLPVLSTLAKNFGVYDHWYAAVPSQTFCNRSFFHASTSHGYVTNIEGDGIGKWLSAPAVPTVFNRLEEAGKTWRVYYDAQQVVSLTGLLSAPSIEQYWKSNFRSMEQFHEDAANGNLPDYAFVEPRMVFDHNDMHPPVVRPDNPSRDDVDPELDSAYSDMRAGEQLLGEVYTAIKHGASTTGSNAMNTVMLVTFDEHGGIYDHVAPPKATPPSGKPEAGEMGFTFDRLGLRVPTIVISAYTKAGSVINEEMHHGSLMKTLAELHGLDPLTERDRTATSIFNAVNLTSPRQPVLWPTVTPAYVPPNPEANARADKDKDRKRPLTPPALGLIGILLAKYEPGAPLPDNYADAYEVLTKHGEGLFGTRD
>NZ_CP040750.1|WP_138945066.1|939833_940925_+|acyltransferase-family-protein
MNSRFHGIDGLRAFAVIAVIAAHAHVPWLPGGGVGVDIFFGISGFLITYLLIQEQKKNGRIALGLFWLRRLLRLMPALILLVVCVNGFALLIAPFTSNDYLNQSAVATPAVLFYFANWMVVGTNSAFLGWFGPLWSLSVEEQFYLVWPLVVLLCFRFRHSLRIIGITAAAIAIGATINRFVIFDGTNLYRTFGTDFRVDMLLAGVLLAIGFQAGGGQAIKKASAFLAAPAALFLIVICVVVPEFASADSADGARLYYTVGLPFVALATVSIIGYLVTHQSSRVARALSWRPFEYTGQISYGMYLWHYPVVELLRAALSNTTLIFVLCLLGTYVAAALSWKLVEQPLQRRFHQRLKPRATAVTT
>NZ_CP040750.1|WP_138945065.1|938501_939728_+|hypothetical-protein
MRRLRQASNLLLYLLIPGLGAATPLLVYPALTAQYGSTGFAAVAVAQSLGLAGATICELGWSVLGPQRVARAQTAERASLYQSALATKLLATLVGAPVAAVAAAVIATDYKPAAAVLAAASVATCLSPGWFLVGANRPLAILAFEGIPRLLIMAGVAGLLLAGAPLLVYGIGTLVAVIFTQVAVALRFGQRVLPRLSAFTSGGAIIKQQLPLTGGRAVSVVYTSLPIAIVGLVNPSAVAVFAAVDRLMRMALAILGGVPSRLQSWVGSAPEDGRVKRSRQSLLMNAALGAISGIGFAVLVPFVANLVFSGTIDIVWQVAVLGGAILFAICASRGFGLSLVAEGRANWIALANVLAAIAGVATTFALTGPLGAPGAQLGGLCAELVGIAVQAFCLFLLKRPPHNTNLTI
>NZ_CP040750.1|WP_138945064.1|937252_938479_+|hypothetical-protein
MRARRKAKRDRVERGFIEASTRVPGANAFAGLNPMSLAVASVRPSDQVRSRVSLIVPEIKAEAIFAGIRTALEVSVGVANSLELPLRIFSLWDEPNPRASASIREFLRDEFGLSRWAEAEVLHVSALTGLAVSADELWIGTHWTTVHPLDVAARLNVIRPDRVIYLAQDYEPGFYPWSTEFALARATYHAGFRMVVNSEPLAAYLRDAEQLDVDPALVFAPSLDLGRLEESAANRRKAAQPSVMFYGRPNKPRNLFAIGISALKLSATSPAGGGVSYSSVGESHATIALSGTATLASRGKLSWQGYFELLSNTDVMFSLQHSPHPSHPPLDSVVSGGITVTNELAGTRAALHPRLLTAEPDPTLLGQRLNDAIEMARSSEPAGFDSTFITKLGAPLTDVVKHASALVA
>NZ_CP040750.1|WP_138945063.1|936149_937220_+|glycosyltransferase
MKIAIFTPDITSNSLGRAYCLWLLMRANSWETEVFAPRGGEIWGPLRGGDFAANCRAVDEDDPELVAAVEAADLVLAVKPVETSFGRARRLARAAQRPLLLDVDDPDLEAALSWRRPLRRFAKGILKFNAVRKNTELKRLALQADTIVSNPVLQAIYGGPVVPHVRDDRGFGAPHTSSKPSIAFVGTNRKHKGVDILREAVANRQDLGITLKLTDEAPEDARPWEQWVGMTSFDEGLALVENADIVVIPSKDDGYAHGQLPAKLMDAMLAGRAVIVSDIEPMTWAVGSGGLTVEPSSVSALASALGEVASPGTRTSLGQEARERALALFTVEAHQDAFREICEGAVRRFSQETGTK
>NZ_CP040750.1|WP_138945062.1|934624_935884_-|hypothetical-protein
MHAVTVKPQRPRIFVWLLGVALLFLIVARSSLMPESIAFITPVIVAVALILALVSFGGGLRIPLSMLGVLALTIILVVSTGAREGTSDTVKALGIGLMWSSALLCGMAMDANVRRFLVRFLLVVATVETGVAVLETLVGLEAIRGSVAGTTSDVYIVRANTILGDWTNRAQGTLGYPIPLAHFLSIAWILTAVSDAIRGRWRWVLLVWLTLGILLTGTRTALVAVAVGLVVAVLVRSRRRVIPVFIVIVAAFGGAGFLANYLAQADESNDASFTHRFGVIQAAQQLFGRDIAYVLFGSGVNSQGSLFGGVIFQDGVTGAIDNTYLTMFICAGLLGFIIFIGFFVTAFIAASAPTRAVLAIFGVFFFSYDAVWWHLIATLFWITIGMAFAERRDRRLNAVEDTTETSPSRVTAVVSGPRR
>NZ_CP040750.1|WP_138945061.1|933517_934621_+|glycosyltransferase
MAPMTQKPIARYYRGARTTHLERLHDSAPGDFFYQKPMYDFDMTRAPAGVQVEQTSFVRIAALVLKGTYSRLEIVEPYAPSALPQNLVLSAAARIGRLFHRQPTQLVTYAIENADLPRKVAASTHLPVAVTRALLRLTVGFCYRSLTRVVFGTADAETNYEALLGARMKRRPPETTLIWGLPTAHPSALTVDSDGPASKVLFVGALDERKGIRQLMDSWSEMLAASPSAELLILGKGPLEAEVLTWAETAPRTTVIIDPTRDVIFEAQRHADVAVLLSQPFTNWKEQIGLPIVEGLSVGTEIVASTETGIADWLIQQGHSVISPSATKDELADAITGVLRTRRPRVEVLRTLPAVDGRLAADQWLFA
>NZ_CP040750.1|WP_138945060.1|932633_933530_+|glycosyltransferase
MDRPEAVSSPQPSIAAVVLNWRDAANTTACIASLAQDGGLKQTVIVDNEADGTLRQALDTSDAPDHVLLERSENGGFSAGVNVGLRYALEAGADFVLVINNDARLHEGALSAMLATFERDASVGIVGPAILNEDGSLQALGPAIGFPLRIDETAGSTSPDFVTWACVLVSRRLLETVGLLDETFFMYWEDVEFGYRARAAGFGIAIAPDATVAHAVSSSHSIAGDRVQLYSAYGLGRVAARQRHFLLASVIRATLRVGKRVAAGRFRFAGDLWLAYRDGLRQTEQPAFERVTKDAWPR
>NZ_CP040750.1|WP_138945070.1|945787_946900_-|hypothetical-protein
MNLKTSRRTAALATGLAVVAGSTLLIAGPASAAEIQVTDDQVAANETVYTGWHEGYGLPGSTTPPGADAVVTDAGLEMTGPSQIINGYAAPVAVDGTTATFAAIAATAGVVSTNNLAYFQIPVYAETGDTNTFTTLRPENPGAAGLTGNWVASSDDIAGIAANTPTSIADLSAALGSFDLLAFGVLVIAGGDDVVQTISFNGDNYNFAAPVVAPVFDPLVVVDPDTIYFSDVRPGGAGFAVTVTGFTPGDTLTISVIDPNGEVFGSADGGDTVIADADGGFAVADLTFVGEGIQVGTYTFRVTDSAGVFAEDAIAVIADPVAAGAPVVPTLADTGSDSGVLVGGAAALLLLGAAGMLFAAARRKGAQVTA
>NZ_CP040750.1|WP_138945071.1|947233_948457_-|acetate/propionate-family-kinase
MPTVLVVNSGSSSFKYQLIDVETERTLASGLVERIGDATGAAEHRSYLPDAAGATTPPIEERWVIEREIPDHTAGFRVMLDAFAEHGPSLDEHAPIAVGHRVVHGGKRFFEPPVVTDLVKINIEDISELAPLHNPANLQGINAAQVAFPDVPHVAVFDTAFHQTIPAAAYTYAIDAELAAKHRVRRYGFHGTSHKFVSEAAAAFLDRPLGELKQIVFHLGNGASACAIDGGRSVDTSMGMTPLEGLVMGTRSGDLDPAVLFHLHRKAGLGFDELDTLLNRRSGLLGLSGTGDMRDVTESASKGDEAAQLALDVTVHRLRHYLGAYLAVLGGLDVVVFTAGVGENAPLIRAGAVQGLEGLGIILDEDRNAERARGIRVISTDDSPVTVLVVPTNEELEIARQTVAALA
>NZ_CP040750.1|WP_138945072.1|948469_950638_-|phosphate-acetyltransferase
MARSIYIISAEGHSGKSTVALGVLDTLSHQIERIGVFRPIARSTTKPDYVLQLLLEHDGVDLAYEDCIGVSYDDVHTDPEAALSRIVQRYKHIEAQCDAVVILGSDYTDVGSPTELGYNARIATNLGAPVLLVLGGRAGQGAGEQLGQSVARTPDDMRNIAELALGELADAHAQLLAVVANRADPDKLLEITAAISDAIHPNGSANGSVVAPAGHAAGAAMVPVWAIPEDTFLIAPTMDSILEAVDGTLVKGSEELLTREALGVVVAGMSMVNVLPRITEGSVIVIPADRTEVLLAALMANASGTFPSIAGIVLNGGFPLPAVVEELISGLGEIPPIVSTDLGTYDTAVRVMNTRGRLAADSQRKYDTALALFEQNVDAPLLLELLNVARADVVTPLMFEYGLLERARSNRKHIVLPEGDDDRILRAAGTLLAREVADLTILGEEIEVRSRAIELGIDLSKATIVSPFDAVLRLKFAEEYARLRAHKGVTIDMASDAVTDVSYFGTMMVHLGLADGMVSGAAHTTAHTIRPSFEIIKTKPGVSVVSSVFLMALADRVLVYGDCAVNPDPTDAQLADIAISSAETAEQFGIEQRIAMLSYSTGDSGAGADVEKVRSATRQVRERRPDLLVEGPIQYDAAADAAVAATKMPDSQVAGRATVFIFPDLNTGNNTYKAVQRSAGAVAIGPVLQGLNKPINDLSRGALVQDIVNTVAITAIQAQEQE
>NZ_CP040750.1|WP_138945073.1|950855_951998_+|hypothetical-protein
MSRTSSWRKALSLPVVISLALGGALLTAGPASAATEPVPSVSATATPTESPAPAESPTPTESEPSASSDAPAPADDAPPVTDEPTVPGEDAPAAPSAAAAPAPAFEVLTPEMGDVFTTQTITFSGVGESGTLVDIAAKDWNYFELEPFAEDVPVVDGAWSVTLDLPLVESVEVAISSTQQTDGADTVVEFNITLPSQAELWGLKMLTPTPMQQFDTRTVTISGVTETDVELRLTVFTAAGESSPITVTGGAWSYTQVFPETSGRVQTVSVVATDGFSRGSTGVTFLLPEPELFPAPVIETPTPGQALVGDVVTFSGTATPNHYIAVALLPTAFYNALQNELEDIANGTGDNARLALPEGRMQHRSTRARRSSSAKTAAGP
>NZ_CP040750.1|WP_168223309.1|951994_952261_+|LPXTG-cell-wall-anchor-domain-containing-protein
MTVAIAPGDYTAVASLVYDPNAAVPQVTSLPSAPVQFTLAATAPATSGHGPTLAETGADTTAPLGLAAMLLLGGLALVAVRKRRAQLS
>NZ_CP040750.1|WP_064294959.1|952725_953376_+|SDR-family-oxidoreductase
MTDVVIAGGHGQIALHLQRLLAEAGHSPAGIIRNPEQVGELQGIGSRAIVLDLEHSSAAELADELAGADVVVFAAGAGPNSGADRKLTLDRDGAILLAEAAELAKVPRYVMVSAMSTDDFDPESDDVFQVYLRAKSEADADLRGRDLDWTIVRPGGLTDDAPTGTITAATTTDRGSIPRADVAAVLFALIESGAASRTQFEVIGGETPIREALAAL
>NZ_CP040750.1|WP_138945075.1|954039_954666_+|hypothetical-protein
MDQRYDPAFQRGHTDERTRPNAADAGRRSHLASLEEIAPQLIQPPSDGRPVRPPTDDRFDDGPRARPSRGMPSQPDRRIHPFEARTGDTTAVADQPGAAGPEAQQTQFDQERYDEYLDAADAHRVRAVVWERVLWIVGVVFTLGGGVGLWQSFTLLYRGFVGDSGPTDNYLWMQFLGALAPTLITIGLATIVALLFKRMLDHDRRSRP
>NZ_CP040750.1|WP_086475010.1|954662_955706_+|MoxR-family-ATPase
MTEQSNTSRAPRDTVAELKPALNAEEFQVLAERILDNVERVLDGKPFAARMALIVMLAEGHLLIEDVPGVGKTVLAKALAASVGSTVRRIQFTPDLLPSDVTGVSIFNQVDREFEFKPGAVFANIVIADEINRSSPKTQSALLESMEERQVTVDGETHALPSPFTVVATQNPLEMEGTYALPEAQRDRFMARISMGYPDASAELAMLRQRDTVNPLDTIGPVASRGDVERLIAWARGVFVSPIVEQYCVSLVQATRVHPELRLGASPRATLQLVRAAKVLAALDGREFVLPDDIDQLLAPVLAHRLIPTRRAVSAHDRSGVQAVSEVLVELLERTPVPHSGRTELRS
>NZ_CP040750.1|WP_138945076.1|955769_957161_+|DUF58-domain-containing-protein
MKRRVPLTRRAVGVLIAAGVCLIFARGIGSPELLAAAGLLVALVAASFGAVYLERPSLRVDRITRPDLVAVGGRISVEVTIAETSALPHVHTEWKDRVPAGLAGSAEGTLPSTGVAGIGSRRRTAEYTVTALRRGEHDLGPLGLTVSDPFGLVVRRRDVGGTHAVVVLPEVVVLPEIPALTASRDGSTRPSSLHVGAGEDDIIARPYLPGDAIRRLHWRASAHHGELMVRQEEQRNDPETTVLLDTAAAHWAWPDDDPSYLPAFEQAVSLAASITAHLVDADYRVNLVGAGTEELFREIGARSASGGLRSSPVGDMGDALARGGQHLEEDDLDAALLDLALLRPSVQPNRFLDLSPVIAARRSQPVIAILGDVEEGDLGELTAVAHLSPLPVALLPAGARRRSIELLESAGWRCHVGERGASFQALWSGTSGPATTTLAPSTGRSDRSGRGGRRGAGGAHVRR
>NZ_CP040750.1|WP_138945077.1|957147_959634_+|transglutaminase-domain-containing-protein
MSVAEERRAAATRDAAARLQAARSGVGPGARSSNPRRPSPGGTSGGSWSGSAGGRRDDPRDTANVGDLRLGLAAFLLLATGGLGFGRVLDALDWWFVTNLVIAIVLATAILLRRTRLPAVFVWLGTGVAWLLTITLFFASETAIIGIVPTPTTLGAFERLRDAGFQTFHDGSAPLDTDAGVVFVMAAGGGLVALVIAWLVLGRHAPVLAAVLVFAVYAGPTVAVSFPLDPWVFAFVALSFLWLLREDVRRRELLRALASARAAGDGRGAGPSAMTGVGRFGGLGPAVLVSAVAVVVALLTPAVLPDLAVRDVTAGARGSGPFVNGINPLISLGQSLRRPANTTALEYTTTADEPPYLKVTDLNEFTGTVWGPDNSGYNDGNTLDAFPAPAGLSEAIPVETFETTVTVDSLSSPWLPLPYPTQKVDGLRGDWRFEAAGLTAMAERGSTRGQTYTATSTAILPTAQQMRDVPPVADPASAAPYLELPDDLPQIIRDTAADVTATASTDYDRAIALQRYFRSTFEYSESAPVEEGFDGSGAEVIATFLERKAGYCIHFSSAMAVMSRVLGIPARIAIGYLPGTTIDNTPANRDTYIVTSDQLHAWPELYFEGVGWVPFEPTASRGVVTQFSDASTATPGSGSVSPDSRPAPTAASTPTPTADALGGPTSTQSGGAFTAALVPLAILLGVLVLLATPSIARGLRRAAGRRRALAEGTSAGWAWAEFLDTARDLGFPVTSAESPRGFASRLRGQFRIESPAVDRLVAAVERESYAPSTGGAASAGSVDAALADAKAALRSASQPLERALAAVLPRSLVLRRNQRVDWRPPAAS

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Crispr_ID: NZ_CP040750_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_7

971105-971216

Orphan

Consensus_repeat	Method
CCCGGTCCCTGAGCCTGTCGAAGGGCGGTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_7

>merge|NZ_CP040750|7|971105-971216|CRISPRCasFinder
CCCGGTCCCTGAGCCTGTCGAAGGGCGGTGTTCGCCCATGCACCGGCCCGCCACCGCGACCGGTCCCTGAGCTCCCACCCTCCCGGTCCTTGAGCCTGTCGAAGGGCGGTGT

>NZ_CP040750|7|7|971105-971216|CRISPRCasFinder
CCCGGTCCCTGAGCCTGTCGAAGGGCGGTGT	TCGCCCATGCACCGGCCCGCCACCGCGACCGGTCCCTGAGCTCCCACCCT
CCCGGTCCTTGAGCCTGTCGAAGGGCGGTGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138945094.1\|977326_978169_-\|TIM-barrel-protein	unknown	unknown	gnl\|CDD\|224007
NZ_CP040750.1\|WP_138945097.1\|980713_982222_-\|alpha-N-arabinofuranosidase	unknown	unknown	gnl\|CDD\|226064
NZ_CP040750.1\|WP_138945099.1\|983287_984244_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP040750.1\|WP_138945091.1\|972484_974482_-\|DUF853-family-protein	unknown	unknown	gnl\|CDD\|283518
NZ_CP040750.1\|WP_168223310.1\|962567_963068_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|182099
NZ_CP040750.1\|WP_138945084.1\|964992_966444_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376836
NZ_CP040750.1\|WP_138945089.1\|970387_970990_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|273701
NZ_CP040750.1\|WP_138945088.1\|969751_970285_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945098.1\|982367_983288_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NZ_CP040750.1\|WP_138945083.1\|964279_964993_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133013
NZ_CP040750.1\|WP_138945086.1\|967794_968805_-\|1-aminocyclopropane-1-carboxylate-deaminase	unknown	unknown	gnl\|CDD\|183494
NZ_CP040750.1\|WP_138945081.1\|963114_963474_-\|DUF4406-domain-containing-protein	unknown	unknown	gnl\|CDD\|379581
NZ_CP040750.1\|WP_138945096.1\|979924_980521_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP040750.1\|WP_138945092.1\|974549_976061_-\|cryptochrome/photolyase-family-protein	unknown	unknown	gnl\|CDD\|225588
NZ_CP040750.1\|WP_138945087.1\|968904_969573_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP040750.1\|WP_138945093.1\|976163_977327_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP040750.1\|WP_138945090.1\|971456_972332_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226100
NZ_CP040750.1\|WP_138945095.1\|978257_979619_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP040750.1\|WP_138945082.1\|963530_964295_+\|DeoR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP040750.1\|WP_138945085.1\|966443_967466_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173838

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138945094.1\|977326_978169_-\|TIM-barrel-protein	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	9.14233e-12
NZ_CP040750.1\|WP_138945097.1\|980713_982222_-\|alpha-N-arabinofuranosidase	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	0
NZ_CP040750.1\|WP_138945099.1\|983287_984244_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.94655e-58
NZ_CP040750.1\|WP_138945091.1\|972484_974482_-\|DUF853-family-protein	gnl\|CDD\|283518	pfam05872, DUF853, Bacterial protein of unknown function (DUF853). This family consists of several bacterial proteins of unknown function. BMEI1370 is thought to be an ATPase.	0
NZ_CP040750.1\|WP_168223310.1\|962567_963068_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|182099	PRK09831, PRK09831, GNAT family N-acetyltransferase.	5.35392e-31
NZ_CP040750.1\|WP_138945084.1\|964992_966444_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|376836	pfam02585, PIG-L, GlcNAc-PI de-N-acetylase. Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyzes the second step in GPI biosynthesis.	1.2089e-18
NZ_CP040750.1\|WP_138945089.1\|970387_970990_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR\|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	1.17464e-10
NZ_CP040750.1\|WP_138945098.1\|982367_983288_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.59647e-76
NZ_CP040750.1\|WP_138945083.1\|964279_964993_-\|glycosyltransferase	gnl\|CDD\|133013	cd02522, GT_2_like_a, GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function. Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.8588e-15
NZ_CP040750.1\|WP_138945086.1\|967794_968805_-\|1-aminocyclopropane-1-carboxylate-deaminase	gnl\|CDD\|183494	PRK12390, PRK12390, 1-aminocyclopropane-1-carboxylate deaminase; Provisional.	0
NZ_CP040750.1\|WP_138945081.1\|963114_963474_-\|DUF4406-domain-containing-protein	gnl\|CDD\|379581	pfam14359, DUF4406, Domain of unknown function (DUF4406). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 98 and 145 amino acids in length.	0.00270368
NZ_CP040750.1\|WP_138945096.1\|979924_980521_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.65871e-11
NZ_CP040750.1\|WP_138945092.1\|974549_976061_-\|cryptochrome/photolyase-family-protein	gnl\|CDD\|225588	COG3046, COG3046, Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only].	2.31187e-147
NZ_CP040750.1\|WP_138945087.1\|968904_969573_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	3.21324e-37
NZ_CP040750.1\|WP_138945093.1\|976163_977327_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	5.79858e-55
NZ_CP040750.1\|WP_138945090.1\|971456_972332_+\|hypothetical-protein	gnl\|CDD\|226100	COG3570, StrB, Streptomycin 6-kinase [Defense mechanisms].	7.45357e-61
NZ_CP040750.1\|WP_138945095.1\|978257_979619_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.60347e-26
NZ_CP040750.1\|WP_138945082.1\|963530_964295_+\|DeoR-family-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.00806e-73
NZ_CP040750.1\|WP_138945085.1\|966443_967466_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	9.40458e-10

>NZ_CP040750.1|WP_138945089.1|970387_970990_-|GNAT-family-N-acetyltransferase
MTDIRAYRPSDRAAVAMICTRTGDSGADATGQFSTDDLLPDIYALPYVEHGPELALLVDAGAGPIGYILGTADTTAFDRWFVERWWPTVEAKYAAAAASGVASESERGIVRSATDRGGLAPELLAQYPAHLHIDLLPETQGMGLGRRLIDAFCELLAERGVPGVHLGVGVSNTGAQQFYQRTGFTRVDGDPGAHWYAKTL
>NZ_CP040750.1|WP_138945088.1|969751_970285_+|hypothetical-protein
MTVRPHPRVLWSAVLSAAIVVLPVWGVSLWLVGPSPSVERTWVITLGIVGMVVLLGVAALSRRQRIVVCRDGFIEQPIVGRQRFVPREAIGRSLLFEFRGRGLSASSQFFVCDSENRPLLRMRSNRWSTDSIAAVVAAYDGPVERPRQPVSLDDLREDHPDLLTPLERLRWARAELL
>NZ_CP040750.1|WP_138945087.1|968904_969573_-|GntR-family-transcriptional-regulator
MPAPAEANPHRRALLRDDVYQSLRNAIVDGTFNPGEKLVDTELERWLGVSRTPIREAVLRLARSGLVIAKPGRSTVVAPLDSRATLQAQAVAAAMHELAVREAVPHLSAADLDRMRAANRDFAAALQRDDADAALAADDAFHAVAVDVAGNPFIRDALEAVTPLLRRIERLRFSSVAARGSIAQHDAVIERCAERDVDAAAALVRGNWTTLADLVLAHLEDD
>NZ_CP040750.1|WP_138945086.1|967794_968805_-|1-aminocyclopropane-1-carboxylate-deaminase
MSLSDFPRYPLTFGPSPVHELNRLTAHLGGATIWAKREDVNSGLAYGGNKTRKLEYLIPDAIAQGADTLVSIGGYQSNHTRQVAAVAAKLGMQAVLVQENWVDWPDSVNDRVGNIMLSRIMGAEVRLDPAGFGIGFKSSWERALDDVRERGGTPYAIPAGASDHRLGGLGFANWAAEVEQQERELGVFFDTIVVCSVTGSTHAGMIAGFAGQDRPRRVIGIDASAKIQETRDQVARIARNTAELIGLERELRDDEITVLEGWAGDLYGIPVESTMEAIRLTGRLEGVIIDPVYEGKSMAGLIDLVTSGDIPASSNVLYAHLGGQPAINAYSALFRD
>NZ_CP040750.1|WP_138945085.1|966443_967466_-|acyl-CoA-dehydrogenase
MIRLQSTAWPTSVTALDLDALHDAATGSLASIESRLAFTSTATRLVGPLQQHTAGRVFAGLGAIAAVDVTLARVVEPHLDALAILHQADLEPPAVSTWGVFAAEAPGLRLNATLVDDAWQLSGTKPWCSLASHLSDALVTAHTAPGERRLFAVALTDPGVTTDDTAWLARGLPLVPSGPVGFDGVPASPVGDDGWYLRRPGFSWGGIGVAACWWGGAVTLVDRLLAAARTRPDADLLLRTLGAAAIDLSIAEQAIADAAQAIEHGHADDAAGPRLAQRVRSTVRGRVDAIRAGVLGALGPGPLTSEPAYLARMSDLELYVQQDHGDRDLARYGRMLVEAD
>NZ_CP040750.1|WP_138945084.1|964992_966444_-|methyltransferase-domain-containing-protein
MPAFDHRDPGTSAAAWATRLHDLDLPAWDGWRHATGVVVLSPHPDDESLGAGGLIAAAAAAGIPVEVLLVTLGEGSHPDSPTTTPEELAPRREAEFVDAVGRLHPTVGYDVLHIPDGGLDAERAGIAERLRAAVATAGSRPLIVAPWRGDGHRDHRIAGELATALATELDLALVEFPIWLWHWADTDDATLPWAEARIVPLDAAAHGAKIAAMDAYPSQTEPLSDAPGDEAIVDHHHLQHYARRFEVLFPNGRALDLAPGSDTEAGAAADSDTETDTATDAVSADTTSRSKESFEDHYRDHPDGWDFGSWYEERKRRVLLAALPRQRYGSVLELGCATGVLTERLADRSDDVLGVDIAEAPLEIARRRVPAARFERGTLPDDWPSGTFDLVVMSEVGYYLSATDLDRVIDHLLGSLTPGGSIVACHWRHPDDHATTSAEFVHRRLLERWPGRRSIQHVEDDFLLDVLVPADEASVAAVDGLTG
>NZ_CP040750.1|WP_138945083.1|964279_964993_-|glycosyltransferase
MLRRIDAVVPAHDEEELIGACLDALLVARAAVLRLRPELQVGIVVVLDDCRDDTARIVRERLAGFDPEEAVTVVIDERSVGAARRAGVAAAVRSGAVDVSERWIANTDADSRVPEDWFSVHADAFDDGVDVLLGTVRPDFTDFSERDIERWMETHPPGHLPGNVHGANLGVRADRLDELGGFRELAEHEDVDLVERARAAGLRVVPTLDAPVETSGRRRGRTPGGYAAFLAETYPRS
>NZ_CP040750.1|WP_138945082.1|963530_964295_+|DeoR-family-transcriptional-regulator
MLSAQRRSHLLDLLDRDGRIVAKDAAAALGLSEDSIRRDLRELAEAGLCVRVYGGALPVPAADRPFRDRLSLGTASKERVARIAAERIRPGSTVIIDAGTTALALARLLPDDPTLTVITPSPAVALAVAEHSPARVIMIGGELGRHSMVAGGALAAEAIRHLSADACFLGVTGFHPEHGLTTGDLDDAATKRALAERSTDVYVLASEEKVGAVSRYPVLDVGEVTEVIVDPQSDRPDPSTRAGGSDALDRQDLG
>NZ_CP040750.1|WP_138945081.1|963114_963474_-|DUF4406-domain-containing-protein
MTTPLLILIAGPYRSGTGGDPDAIARNLERLEAAAAPIYALGHVPMIGEWVALPILRGMDTASGDGDVMYETARRLLQHCDAVLRLPGESSGADTDVAIARERGIPVYTDLSEIPALED
>NZ_CP040750.1|WP_168223310.1|962567_963068_-|GNAT-family-N-acetyltransferase
MLDDARIRRYRDTDARATRSIFERAVRVTAAAHYTAEQLAAWVPDDPPGAVLDDWAARRAAVKTWVAELDDSVVGFTDLDLETGYLDMLFVDPGAGRRGVGSALIRQVLDEARVVGLHEVTVQASRTAQPVFERHGFVVVREQRVERRGVLIENAVMRMPLDASAG
>NZ_CP040750.1|WP_138945090.1|971456_972332_+|hypothetical-protein
MTWRPGGIDAAVEQWRLVPDGELIVTPSSRLLPVTHEGRPAMLKVPLVEEEALGGRLLAAWAGAGCAAVFASDDHAIVLERATGGRGLSSLTRAGDDLGAVAILCSVLDTLHAAIPAPVPIGADGVIAELPTLRRWFRELLADDASALGALLGDPASAAFLERGRELAGRLLDTTTPTDVVVLHGDLHHMNVLEFAAGDWRAIDPKGIVGHRAFDATALFSNPDPATARNPRLFAERVGLVSRSLGLSRTILLEWVVARSALSAVWSLQDGLLDDARATIELGRLAEDGLR
>NZ_CP040750.1|WP_138945091.1|972484_974482_-|DUF853-family-protein
MTPSDAASDPQIAALQAAAAHAQAELEAAQAQAALAAAKVKAAEAAAALAGAGITASGGVTASASPVEPAGPGSASDAPTAEAPSDTPADVSTDDAVGAEPSSTATGTDDLSADTIGPGPLGLDDVLKIRDGYLVHGPALEMGALVNGEPLPGVQVRIPLSVMNRHGLVAGATGTGKTRTLQGLVEQLSAAGVPVFAADIKGDLSGIATPGESNEKLLDRTRGIGQDWTPAATPTEYFALGGVGKGVPIRATIAAFGPLLLSKVLGLNATQESSLGLVFHYADKAGLPLLDLSDLRAVLTYLASDDGKGELQELGGLSGATVGVILRELITFADQGADVFFGEPEIDTADFIRLDPSGKGIVSLLEVPGVQNQPALYSTFLMWLLADLFNTLPEVGDPEKPKLVFFFDEAHLLFRDASKDFLAQITQTVRLIRSKGVGIFFVTQTPKDVPGEVLAQLGSRVQHALRAFTPDDAKALKATVSTYPTSGYELGEVLTSLGTGEAVVTVMNEKGAPSPVAWTRLRAPQGLMSPSSDTAIDAAIAASPLLARYGTPVDRESAREILTAKLEEANQAALAAEAELERQRIAAELAKQQAAADKAQAAAQKKADAEYERLLRKTAGTTRRTSTRSSSTSSKSPLEEILGSKATRSILTGVVEGIFGTRRRR
>NZ_CP040750.1|WP_138945092.1|974549_976061_-|cryptochrome/photolyase-family-protein
MDTTGRRAAEHPDDATPRRRWILTGQLGPAFDDGGPILLIESKSTFTKRPMHRAKAHLFLSAIRHRAAELGDRAEFHQVDRYEEVVEAGADLEVIDPPSWTARRFVRERGLRVLPSRGFVTSEPDFAAWASTRDGKRLLLEDFYRTVRERTGILMRGDQPEGGRWNYDHDNRNPPPKGAARLGLPEPLWPEEDAIDAEVREDLDRWQRDGLVQLVGDDGPRRFAVTAAEAEAALADFIETRLGDFGPFEDAMLGGDWTMAHSLLSAPLNLGLLDPRDAVDTVVAEYHAGRAPLSSVEGFTRQIIGWRDYVWHLYWHLGEPYRTSHNALGAHEPLPRQFRELDAAAIQSNCLRETIDGMRRHGWAHHIQRLMVLGNWALQHGYDPVALNDWFIDMFVDGTPWVMPANVIGMSQHADGGIVATKPYASGGAYIDKMSDYCGGCVFNPKVRLGEDACPFTAGYWAFLDRVEPRIRHNTRMAQPLAGLRRLSDLRAVVDQERTREQW
>NZ_CP040750.1|WP_138945093.1|976163_977327_-|Gfo/Idh/MocA-family-oxidoreductase
MPAAAQGTTARAPQGSGPVGVGFIGTGMISDTYLEHLTAFPDVRVVILGDLDVDRAKAQAEKWGVGEWGTADDVLAHPDVELVVNLTIPAVHAQVASQVLAAGKHVWTEKPISVDRASGLALLEQADAAGLLVGIAPDTVLGPGVQSARRAIARGDIGQPLTAQTVMQYAGPDIFHPNPEFLFAKGGGPLFDMGPYYLTTLVQVFGSVASVSAAGSRGRATRTIQQGDRVGTEFAVEVPTHVSAIARFVDGGVSQSVFSFESPLAKMGVVEITGTEGTLVIPDPNMFTGEVRITRAAPIERMQQDPEWEVVPTEGVLAGRGTGVLDLARAIRSGGTPLASGALGYHVLDTLVSIDESVVSGQTVDVASRVAPVPLVAEDWDPFAATL
>NZ_CP040750.1|WP_138945094.1|977326_978169_-|TIM-barrel-protein
MTAPALSVQLYSIKEHLDQGLDDALARLAGMGLREVEAFDFVSRAPALREAFDRHGLAARTGHATLLSDEIRFGDQVMPVASQEDVFAAATTLGLEIVIDSFVSPDRWLDQAAVADTAARLNAAAERAADHGLRVGYHNHSQEFVASFGGRSAFEVFADQLRDDVALEVDLFWAATAGQDVPALLGRLGDRVQALHVKDGLLPADPFAPGAAPFVPTSLDQRPFGQGEVPLRESLAAAPSARFAIIEFDHYGAGDIFDGVQASVDALVAEQLVSTEAVVR
>NZ_CP040750.1|WP_138945095.1|978257_979619_-|MFS-transporter
MSNPPRRPKPTGQRASSGPYVSLVTGPSGPTERASKRVVTTMALAQFGLFVALLAPVTVSLALKTQQLVPGDQAAVVNGNVLSIAALFALVANPVIGRLSDITLSRFGRRRPWMFLGAIGFVASLTIVALAPNVPVLIAGWCLAQLTGNAILGPLLATIADQVPPEQRGSVSANVGVMQNVGILAAAFVASWFVTDMLLLFVAPAVFALITVWLYCFVLPDRAITTRPDVGGWRGLLFTFWVNPLKHPDFGWVWLSRFLLTLASFLFVAFRLFFLQEEVGLSQQGAVDTLTMGVLIYTIALVITAKLGGWLSDRMLNRKVFVIGSTVVFAVGLVLLAHTTTVPMFYVVEAIMGAAYGVYVAVDTALVVDVLPNPDDAAKDLGVLNIANALPQSLAGAVGAFLLGLGAVGNNYTALFWGAGVIAVLGALTILPVRHRMTRNADGTITGSIATRG
>NZ_CP040750.1|WP_138945096.1|979924_980521_-|TetR-family-transcriptional-regulator
MTARGSYAKGVARREEILRVALAVFAREGYRGTSLREVAREVGVSLPGLMHYFESKEHLFAAILRERDAVDYEEFAAAGSQDAIEGLVAVMRHNSDVPGLVELYLTMAAAAGDAEHPARAFLVEHVAGVRRSIADVVRDRQASGRVAAGIDPDHVARVMVALADGLQVQWTLDPSVDMAGDLERAWALLVGDDAGAVR
>NZ_CP040750.1|WP_138945097.1|980713_982222_-|alpha-N-arabinofuranosidase
MTTARIAIDPNVTVAPVNRRIFGSFVEHLGRCVYDGIYEPGHPTADADGFRGDVVDLVTELGTSTIRYPGGNFVSGYRWEDGVGPRENRPVRRDLAWHSLETNQVGVDEFAKWCKLTGSEMMMAVNLGTRGVLEALDLLEYTNHPSGTALSDQRIANGAPEPYGISMWCLGNEMDGPWQVGAMSADDYGKLAARTASAMKMVDPKLELVVCGSSSSSMPTFGDWERTVLEHSFDSVDYISCHAYYQERDGDLGSFLASSLNMEYFIRTVVAAADHVQHKRHSDKQIQLSFDEWNVWYLDEWNAIEGTIEEWAYAPRLIEDVYSVADAVVFGNLLMTLLKHSDRVGSASLAQLVNVIAPIMTEPGGGAWRQTTFFPFSVTSRLASGVVIAPRIEVGSYTTKVHGDAPLVDSVATYDAEAGTAAVFLVNRHQDEAITVTIDVSALGVGSIVEANGIHDEDVYAKNTIDDRERVGLVANESASLADGTLTITLPPVSWTAVALGA
>NZ_CP040750.1|WP_138945098.1|982367_983288_-|ABC-transporter-permease-subunit
MSATTAIPAVNPKAGRRRQGPEARTGGRRVGSHLFLLALVIYFILPLWWLIVAATKDTSGLFTGSGGPLWFDGEFNFFDNVAELSTHQGGIYWRWLGNSFLYAFSGGIGATVLAVLAGYGFAKYRFRGRSLFFNLLLGAVMVPLTALVIPTFVLLSQVGLVNTIWAVILPSLLSPFGVYLMRIYTQDAIPDEILDAARVDGAGELRTFFQVALPLLRPAIVTVLLLSIVGTWNNFFLPLAVLSDPNLLPVTVGLNNWTALSNAGAGGEQVWNLIVTGAFISIVPLIIAFLSLQRYWQGGLSLGSVK
>NZ_CP040750.1|WP_138945099.1|983287_984244_-|ABC-transporter-permease-subunit
MALTTGSASTAVSAARIVRPRRGGIGAIDRRRQRWGWLFVAPFAVVFAAFLIFPLCYAFWMSLQTSTLATGTEFTGLANYAKAFTDPIFLSGLARVAMFALVMIPAQMLVALVAALVLDNLATVLSKFSRLMIFVPYAIPVVIGALMWGFLYSPRFGPATDVFALFGATAPSFLDQSSIFGSLVNIVTWQWSGYYMIIIYAALRGIDPSIYEAARIDGANAFQTALRIKVPMISSSMVMVLIFAMIGTLQFFTEPQVLRGVAQGAIPISYTPNMYAYSLAFSYSQFNYASAISFALGIIVFIGSYVFLFLTRKQSGLK

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Crispr_ID: NZ_CP040750_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_8

1020772-1020874

Orphan

Consensus_repeat	Method
GCTGCCCACAGCAGGCCCCTTTCGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_8

>merge|NZ_CP040750|8|1020772-1020874|CRISPRCasFinder
GCTGCCCACAGCAGGCCCCTTTCGATCATGGCGCGGCCGGCGTTTCGGCACCGGTCCTCGACGATCCCGTTCAGCGTGCTGCCCACAGGAGGCCCCTTTCGAT

>NZ_CP040750|8|8|1020772-1020874|CRISPRCasFinder
GCTGCCCACAGCAGGCCCCTTTCGAT	CATGGCGCGGCCGGCGTTTCGGCACCGGTCCTCGACGATCCCGTTCAGCGT
GCTGCCCACAGGAGGCCCCTTTCGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_064294998.1\|1015262_1016282_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380488
NZ_CP040750.1\|WP_138945123.1\|1034199_1035360_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP040750.1\|WP_138947196.1\|1033150_1034107_-\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|223085
NZ_CP040750.1\|WP_064295008.1\|1027478_1028669_+\|xylose-isomerase	unknown	unknown	gnl\|CDD\|237170
NZ_CP040750.1\|WP_064295024.1\|1010837_1012346_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP040750.1\|WP_079003218.1\|1022539_1023415_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP040750.1\|WP_079706775.1\|1012483_1013596_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380649
NZ_CP040750.1\|WP_138945120.1\|1028799_1030233_+\|xylulokinase	unknown	unknown	gnl\|CDD\|198375
NZ_CP040750.1\|WP_138945118.1\|1021586_1022540_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NZ_CP040750.1\|WP_138945119.1\|1023473_1024784_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NZ_CP040750.1\|WP_138945117.1\|1019616_1020759_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP040750.1\|WP_138947195.1\|1024834_1025989_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP040750.1\|WP_168223312.1\|1013703_1013844_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945113.1\|1014109_1015129_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP040750.1\|WP_138945115.1\|1018347_1018959_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945116.1\|1019091_1019595_+\|YfcE-family-phosphodiesterase	unknown	unknown	gnl\|CDD\|223695
NZ_CP040750.1\|WP_138945122.1\|1032033_1033146_-\|glycerate-kinase	unknown	unknown	gnl\|CDD\|376844
NZ_CP040750.1\|WP_138945114.1\|1017793_1018267_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP040750.1\|WP_138947194.1\|1016506_1017655_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP040750.1\|WP_138945121.1\|1030947_1031991_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176215

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138945119.1\|1023473_1024784_-\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	9.46362e-53
NZ_CP040750.1\|WP_138945123.1\|1034199_1035360_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	6.36079e-28
NZ_CP040750.1\|WP_138947196.1\|1033150_1034107_-\|M24-family-metallopeptidase	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	2.54156e-14
NZ_CP040750.1\|WP_064294998.1\|1015262_1016282_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380488	cd01574, PBP1_LacI, ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of LacI is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	7.36328e-107
NZ_CP040750.1\|WP_064295024.1\|1010837_1012346_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_CP040750.1\|WP_079003218.1\|1022539_1023415_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.01524e-59
NZ_CP040750.1\|WP_079706775.1\|1012483_1013596_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380649	cd19994, PBP1_ChvE, periplasmic sugar binding protein ChvE that interacts with a bacterial two-component signaling system. Periplasmic aldose-monosaccharides binding protein ChvE that belongs to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	8.60083e-155
NZ_CP040750.1\|WP_138945120.1\|1028799_1030233_+\|xylulokinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	8.26899e-142
NZ_CP040750.1\|WP_138945118.1\|1021586_1022540_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.22198e-75
NZ_CP040750.1\|WP_138945117.1\|1019616_1020759_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	6.85993e-64
NZ_CP040750.1\|WP_138947195.1\|1024834_1025989_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.26647e-63
NZ_CP040750.1\|WP_064295008.1\|1027478_1028669_+\|xylose-isomerase	gnl\|CDD\|237170	PRK12677, PRK12677, xylose isomerase; Provisional.	0
NZ_CP040750.1\|WP_138945113.1\|1014109_1015129_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	3.94668e-48
NZ_CP040750.1\|WP_138945116.1\|1019091_1019595_+\|YfcE-family-phosphodiesterase	gnl\|CDD\|223695	COG0622, COG0622, Predicted phosphoesterase [General function prediction only].	2.45174e-37
NZ_CP040750.1\|WP_138945122.1\|1032033_1033146_-\|glycerate-kinase	gnl\|CDD\|376844	pfam02595, Gly_kinase, Glycerate kinase family. This is family of Glycerate kinases.	2.07246e-122
NZ_CP040750.1\|WP_138945114.1\|1017793_1018267_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.76759e-10
NZ_CP040750.1\|WP_138947194.1\|1016506_1017655_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.32593e-39
NZ_CP040750.1\|WP_138945121.1\|1030947_1031991_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176215	cd08253, zeta_crystallin, Zeta-crystallin with NADP-dependent quinone reductase activity (QOR). Zeta-crystallin is a eye lens protein with NADP-dependent quinone reductase activity (QOR). It has been cited as a structural component in mammalian eyes, but also has homology to quinone reductases in unrelated species. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.55938e-118

>NZ_CP040750.1|WP_138945117.1|1019616_1020759_-|Gfo/Idh/MocA-family-oxidoreductase
MSETTGGSVLRVGVIGVGNISKQYFAEFPKLPNLELVVVADLDLARAAEVAAEQGVRSSSVDELLADPEVDVVLNLTIPAAHAEVALRALQAGKHVYGEKPLALSTAEARPVLELAAAKGLRVGSAPDTVLGSGVQTALAVLDSGAIGRPIAAAVAWSAPGHELWHPAPAFYYQPGGGPLLDMGPYYLTSLVSFFGPVVRVSGAVARSDRERSVATGALAGTPIPVHEEVDTHVTAILEHANGVVSTVTVSFEVWASRVPLFEVYGTGGTVAVPDPNRFSDPVEIATADDRTWRAVPDSAGFVDAGRGVGLSDLAEAIEQDRPHRASGDLAFHVLEIMEAIIVAGREHRVVELTSTVPVRHPWPANCHSGTVPAARTSVE
>NZ_CP040750.1|WP_138945116.1|1019091_1019595_+|YfcE-family-phosphodiesterase
MPTSLLLLADTHLPKRAKVLPDAVWAAVDAADLVVHAGDWVDEATLDALEARAARLVGVFGNNDGPGLRARLPEVARFELDGLRFAVVHETGAATGRERRADEAFPDTDVLVFGHSHIPWDSVSPAGLRLLNPGSPTDRRRQPECTMMTARVTDGTLTDVRLIPVAR
>NZ_CP040750.1|WP_138945115.1|1018347_1018959_-|hypothetical-protein
MPAIDLRFSGRIAGYGTTGGVRIVLGLWSTSPFGSFADAMIEDSRGKRLLLAPTQEIADFISSTYTFDDVEIGTVGWTRLPTGLRFVGGPLDTTLRIGGSSPLGRALRVVPKPVAVNPVWLQTIDPLARVLQPGARTAGSAGNGRREYYGVTGARRITAATASWSGADLGTLARLDPPVRFGFGSAPADPHLVDIVTTVRQPA
>NZ_CP040750.1|WP_138945114.1|1017793_1018267_+|GNAT-family-N-acetyltransferase
MPAAWTLRPATIDDSTWTAELRAVVMRPDLERLGRYDETRVRRRFLDGYRPEHTSVIEVDGVAAGLVALRPEPGERWLEHFYLAPEHQGAGLGTAVLARFLSDDGDPRPFRLNVLQGSPARRLYERHGFTLEREDEVDVWMVRGTGAGDRHGSRTFG
>NZ_CP040750.1|WP_138947194.1|1016506_1017655_-|ROK-family-protein
MGSGLDSVRRRNLGRIVELVHQGGVQSRSALTRATGLNRSTVAALVTELASTGIVTESVPVGGQGVGRPSPLVSAGPRAVAFAANPELDAITVAAVRLGGEVVERVRREVDTTPTAAEATAIIAELVAELAARLPDEARGGGGIGLAIPGLVRDADGVVRLAPHLGWVDEPLVERLRAATGRAVFAANDASLGARAERTFGAGRGIDDLVYLNGGASGIGGGIIAGGRPVGGARGYAGEFGHTSATAAGNALEDAVRRSELLRVAGLTAGDDAVLEAALAEGIAADPAGAMREEVVRQARTLGRALAGTVNILDPELVVLGGHLGIVLELASEELHDAVRERALVPPFEDVTIVRAELGQDLLLIGAAELAFDRLIADPAAW
>NZ_CP040750.1|WP_064294998.1|1015262_1016282_+|LacI-family-DNA-binding-transcriptional-regulator
MSDDAERGRAPNIRDVARLAGVSHQTVSRVLNNHPSIRDSTRDRVLAVMDEVNYRPNRAARALVTSRSRTIGVLASQRSQYGPASMIQAIENASKDAGYLVSTANLPDVSDASIVAAVEHLLAQSVDGIVVIAPQVRVFRAIEELQVRVPFIAVQSGGDLDDHSIGVDQVAGGRLATRHLIELGHRNIYHLAGPQDWIEAEARMHGFLAEMSAQDVPTTAPILGDWTADFGYRAGIELMRVRDFTAIFSSNDQMALGLIHAIRDEGYDVPRDVSIVGFDDIPEAPHFWPPLTTVRQDFDELGRRCVARLLGNLEVDAVGYRGTIEPELIVRKSTGRPAF
>NZ_CP040750.1|WP_138945113.1|1014109_1015129_-|serine-hydrolase
MDTESVARVIEATDFSGVVLVKRGDETLFEAARGLASRERDEPITLDTRFDTASITKLFTAAAVLQQVDAGHIDLDESIHEYVDLDGTTIRRDVQLLHLLTHTSGIADDADETAGESYDDLWAERPASSIRETADLLPLFADKEPLAAPGEEANYVNAGYVLLGLALEGVTGLPYRQLIEQQVFALVGMDHSGFVDRRTGEPGLAEGGDVDDDGVWHSNADAFPPLGGPDAGAQSTAADLITFLRAARDAKILTAELTEEFTSPQIEVDEEISYGFGFEFDVDEDGQVRSMYLDGVNPGASGIVRTYFGPTAADAIDVVVLSNSEDGAWDVIRAIDAEL
>NZ_CP040750.1|WP_168223312.1|1013703_1013844_-|hypothetical-protein
MSHLPIHGTDRSDHSSLSARLSAGHLSLHPRRHHDEASAPAPANAT
>NZ_CP040750.1|WP_079706775.1|1012483_1013596_-|sugar-ABC-transporter-substrate-binding-protein
MLLATLAAGTMVVSLAGCSGGASGGSGGGEGDGKLVGVAMPTKSSERWIQDGNAVKEQLEKEGFKVDLQYAEDDIPTQVSQIENMITKGASVLIIASIDGTTLTSVLQEAKDGDIPVIAYDRLIRDSENVDYYASFDNYKVGVQQANSVLNGLGLVDLEGKPTEGAPAGPFNIEMFAGSPDDNNATFFWDGAQDTLKPFIDAGTLKVASGQTSFEQAATLRWDGETAQKRMENILTSTYSDGSKVNAVLSPYDGISRGIISALTDAGYSVGDGWPVISGQDAELDSVKAIESGEQYATIFKDTRQLASEAVKMAVAVLNGEKPEVNNTEDYDNGKKVVPSFLLESQIVVKDNIQEVLVDSGYWTEDEIKG
>NZ_CP040750.1|WP_064295024.1|1010837_1012346_-|sugar-ABC-transporter-ATP-binding-protein
MRNIIKTFPGVKALSNVTLDVQRGTVHAICGENGAGKSTLMKVLSGVYPFGTYEGDIVFEGETMEFKDIRDSESKGIVIIHQELALSPYLSIAENIFLNNELKGPLGLIDWNRTNQEAAALLARVGLRENPTTKILEIGVGKQQLVEIAKALSKRVKLLILDEPTAALNDEDSDHLLDLILHLKEQGITSIIISHKLNEIKKVADTVTVIRDGKTIETIVKNDVTEERIIKDMVGRDLEHRYPDHTPNIGEEILRVEDWTAHHPQDPTRVMVDAVNLNVRAGEIVGIAGLMGAGRTEFAMSLFGQSYGSRISGKVFKNGTEIRTRTVSEAIDNGLAYATEDRKYYGLNLIEDIKRNISMASLKKLERGGLVNDNEEYKVAEEYRKSMNIKAPNVLAKTGKLSGGNQQKVVLSKWIYSDPDVLILDEPTRGIDVGAKYEIYTIINRLAAEGKGVIVISSELPELIGICDRIYALSEGRITGELPIEEANPEALLKLMTMEKPR
>NZ_CP040750.1|WP_138945118.1|1021586_1022540_-|ABC-transporter-permease-subunit
MSATNPLTKPGALPTGSLDTVSVSTAGSKRGRPGEHETRGKRPRGARRKPNIIGGIGAWIWLLIIVLPIYYIVITSVRPQAGFFSSNQLIPPSDPTLDGYALVLQSDFFLYLGNSVIITVASVAVTVFVCLMASYAIVRTNSRFTRGAFSFFLLGLAIPLQATIIPLFYMLSKAGLYDTLLALILPSIGFAVPVTVLILSNFIRDIPKELFESMTVDGASSWRTLVSLVLPLARPAIVTVALYNALNVWNGFLFPLVLTQSPSNRVLPLSLWTFQGSFSVNVPAVLAAVVLSTLPIFILYLFGRRQLISGMTAGFSK
>NZ_CP040750.1|WP_079003218.1|1022539_1023415_-|sugar-ABC-transporter-permease
MRRRTGPSGWMVAPALGFFLVFAIIPLIVALYLSFTRWDAITDPAWVGLDNWASVLVDPVAIDALVLTLKVIVISWIVQTPISLLLGTWTAGKQRNRAVLGAIFFLPLLLSSAATAIAFKAILDPNFGLSASLGIPFLKQDWLGNQQLVLFVVIFIIAWQFVPFHTLLFQGGVRQIPASLYEAAEIDGAGTVKQFFHITLPQLRYTLVTSSTLMIIGSLTYFDVIFVLTGGVPSAGTRILPILMYVTGFSASQFGQASVMAIILAVIGLAIALLLTKLSGFAKMDSQQEGL
>NZ_CP040750.1|WP_138945119.1|1023473_1024784_-|extracellular-solute-binding-protein
MTLRTSSRRRTRLAAVALGVSALMLGATACSSGGGAPRGSATLWGLTGTDEDTVLGPSLKEWNGANADGQVAATYFQNDAYKTKIRTAVGAGSAPTIIYSWAGGTLNSYVDAGKVADITSETADAKGKFLESVWNQGVIDDKVYAVPMNATTPIMFYYNKDVLKAAGVEVPTNFDEIVDAIPKLKAAGVAPFSLAGASKWPSLMWEEYLVDRVAGPEAFNKIMAGEADAWSDPGIIEANEKIQELVKAGAFVDGYASVTADSNADVALLYTGKAAMMLQGAWVMTTFKQQAAEFAEKGLGYTTFPAVTGGKGDPSNIVGNPSGYFSISASATKEQKASALKYLTEGVFDKGYIDRMVEAGQVPPITGIDDQIADAGGDFGTTVYDLTKNAKNFQMSWDQALPPAQATALLTNLDQLFNLQITPQEFSDDMNKTIGQ
>NZ_CP040750.1|WP_138947195.1|1024834_1025989_-|Gfo/Idh/MocA-family-oxidoreductase
MIGYGFMGAAHSQAWRTAPRFFDLDAEPVMATIVGRNPEALEAARVKFGWESASTNWRSVIADPSIDIVDVCTPGSSHVEIAIAALEAGKHVLCEKPLANSVEEAELMVAAAEAARARGVRSMVGFSYRRVPAIGYARQLIAEGALGDVRQIRALYLQDWLSDAEGPMTWRLDKDQAGSGSLGDIGAHAIDLVQHLTGARLDTVSGTLATFVTERPLLGETVGLSGTASEERGAVTVDDAAWFTAKLTGGLADGAIGAFEATRYATGRKNALRIELSGSRGAIAFDLERMNELEVYDATAPAGKQGFTRIVVTEPEHPYMAAWWPTGHGIGYEHPFSHQVRDLVQAITAGTDPEPSFADGLQVQRVLRAVESSAANGSAWTPTD
>NZ_CP040750.1|WP_064295008.1|1027478_1028669_+|xylose-isomerase
MSLTPTKADRFSFGLWTIGYNGTDPFGGPTRPDLDVVEAVTRLNDLGAYGLTFHDDDLFAFGSTDAERQKQIDRLKQALADTGVIVPMVTTNLFSAPVFKDGGFTSNDRAVRRFALRKVLRNLDLAAELGAKTFVMWGGREGAEYDSAKDVQAALERYREAVNFLGDYVTDKGYDIRFAIEPKPNEPRGDILLPTLGHAMAFIETLERPELVGINPEVGHEQMAGLNFTAGIAQALYQGKLYHIDLNGQRGIKYDQDLVFGHGDLQNAFSLVDLLEHGGVNGGPAYDGPRHFDYKPSRTEDITGVWDSAAANMRMYLLLKERAEAFRADPEVQEALAAARVPELREPTLNPGETVEQLLADRSSYEDFDADAYFGGKGFGFVRLQQLAVDHLMGAR
>NZ_CP040750.1|WP_138945120.1|1028799_1030233_+|xylulokinase
MTLVAGIDSSTQSCKVVIRDAETGALVREGRAAHPAGTEVDPAAWWQALQEAAAAAGGLADVAAVSVAAQQHGMVALDVDGRVIRPALLWNDTRSAQAATDLITEFGAAELAQRTGCVPVASFTITKLRWLRDAEPGNAAEVAAVALPHDWLSWRLRGFGPADESPLGADLAELTTDRSDASGTGYWSPADGEYDRELLVAALGHDAILPRVLPPEESAGTGVDGGLIGTDTVIGAGAGDNAGAALGLGAMAGDVVVSIGTSGTVFAVTPAVVRDSSGTVAGFASADGAFLPLIATLNAARILDAVAALLGVDHAELGRLALEAPAGARGLVLQPYFEGERTPNRPDATATLFGMTLESTTREGLARAAIEGLLCGLADGLDAVLAQGVTAERVLLIGGAAQNPAVQAIAREVFDVPVVVPAPGEYVADGAAVQAAWALSGTRPAWAAVGAGDGADQADAVAADTSGIAREQYAARA
>NZ_CP040750.1|WP_138945121.1|1030947_1031991_+|zinc-binding-dehydrogenase
MRSIVYSTNGDPSVLHLVERELPEPGPGEVRVKLAFSGVNPTDWKTRRGGGPSGGMPFPEVVPNLDGAGVIDAVGPAAGDAASTTTFAVGDRVWVYLAAHESPLGTAQEFTVQPVSRVVPLPDAASFELGASLGVPAMTAHRALTVAQDGPTRLSPGALDGRTVLVQGGAGAVGNAAIQLARWAGATVISTISSDEKARLATAAGAHHVVNYREGDTAAAIREVAPDGVDLVVEVAIAQNLPLDQAVLAPRGTVVSYANNGGDQITLDIRPHMGLNTRLQFMLLYTVGDAALQAAAEDITAAIEDGALHVGEDHGLALTVFPLAETAAAHAAVEDDTVGKVLIDVTA
>NZ_CP040750.1|WP_138945122.1|1032033_1033146_-|glycerate-kinase
MTRHIVIAPDSFKGTATAAEVAEAIADGWRTVRPDDLLQSLPMADGGEGTLDAFAAAVPGARRHPITVTGPVGDPVVAEWLELPDGSAVVELAQTSGLTLLDPLQPFAAHTAGFGEAIAAALDHGVRRLLLAIGGSSSTDGGAGLLTALGARLLDADGGSAAVGNAGLATLRDIDTAGLRALPPDGAVILSDVTNPLLGDRGAAAVFGPQKGATTSDVAALDANLARFVSRAAEAFGTGRAERAAVEPGAGAAGGAGYGLLLWGATATSGARGVGEAIALPEAAAAASIVITGEGRFDDQTADGKVASWVAGLASDRTMLVAGAIQAPTEGIFLAAASLTELAGGVEAAMAEPLVHLRAAGAALANQYRP
>NZ_CP040750.1|WP_138947196.1|1033150_1034107_-|M24-family-metallopeptidase
MLRSAAAVSWYLDGSRVHVSLAADPIVAVVVSPGDAWLVATSNEVDRLQAEELPDIRVRTVPWHTPIDAVLPSGDGVLQEADVAAELRAARASLLPAELARFRSLGRETTSALETLVDELDPARTERAVAADLAGRLVAAGIDPLVLLVAGEGRLAHRHPLPTEGRLGSRAMLVACGRRDGLIVNLTRWFDEGGTPAEPFATDMQCIRAVERAYLDATVPGASLADILRAGSAAYAEQGFDADEWTRHHQGGAAGYAGRDPRATPEANDVVQPWQAFAWNPTAPGVKVEDTVVVTPDGIEVLTTSTASAHPIPSTVGG
>NZ_CP040750.1|WP_138945123.1|1034199_1035360_-|Gfo/Idh/MocA-family-oxidoreductase
MTSTDHPTAPTVVVVGIHGHGASHVAAARALAATGAIRLVGLVDRTFTEEDRAAGDAPLCDSLEECFAAGRVDVVILSTPIHTHLDLAVAALEHGADVLLEKPPVTSNDELDRLQATAARTGGLVQVGFQSLGSHAIDEIANVVTGGEIGAVTALEARGTWVRTVGYWTRAAWSGRRTLDGTPVVDGVVTNPFAHAVQTMLRLGGTTDRAAIATIDLDQYRANDIEADDTSVVRITPQRGPIMTAALTLCAQETTDPVVTVHGELGSIRFHYTRDEVELVVDGVTLRRWTTGRTDLLPDLLRAREAVRAGEDAALVSSLADASAFTAVLDAVRSAPAPHRIPADLVEWLGAGDERRPVIPRIEELVAEAAASGSTFAELGTDWARR

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Crispr_ID: NZ_CP040750_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_9

1245488-1245584

Orphan

Consensus_repeat	Method
TCGACCCTTCGACAGGCTCAGGGACCGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_9

>merge|NZ_CP040750|9|1245488-1245584|CRISPRCasFinder
TCGACCCTTCGACAGGCTCAGGGACCGGGATTCGGCTCAGTGACCGGGTGGATCGGACCCCGAGTCAGTCGACCCTTCGACAAGCTCAGGGACCGGG

>NZ_CP040750|9|9|1245488-1245584|CRISPRCasFinder
TCGACCCTTCGACAGGCTCAGGGACCGGG	ATTCGGCTCAGTGACCGGGTGGATCGGACCCCGAGTCAG
TCGACCCTTCGACAAGCTCAGGGACCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138945289.1\|1246322_1247588_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP040750.1\|WP_138945282.1\|1238379_1238565_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945285.1\|1240608_1240893_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_CP040750.1\|WP_138945292.1\|1249667_1250066_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_168223331.1\|1250169_1250466_-\|pyrimidine/purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|377724
NZ_CP040750.1\|WP_138947209.1\|1241680_1243165_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225080
NZ_CP040750.1\|WP_138945295.1\|1252784_1253636_-\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|236477
NZ_CP040750.1\|WP_085513978.1\|1241141_1241573_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP040750.1\|WP_168223329.1\|1238073_1238229_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945284.1\|1240242_1240479_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|376540
NZ_CP040750.1\|WP_138945288.1\|1245673_1246330_-\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP040750.1\|WP_168223330.1\|1238561_1238708_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945283.1\|1239703_1240246_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|379158
NZ_CP040750.1\|WP_137243990.1\|1254308_1254992_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319828
NZ_CP040750.1\|WP_138945286.1\|1243161_1243722_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NZ_CP040750.1\|WP_138945296.1\|1253788_1254298_+\|DUF1622-domain-containing-protein	unknown	unknown	gnl\|CDD\|377914
NZ_CP040750.1\|WP_138945290.1\|1247764_1248850_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|223650
NZ_CP040750.1\|WP_138945287.1\|1244099_1245470_+\|deoxyribodipyrimidine-photo-lyase	unknown	unknown	gnl\|CDD\|223492
NZ_CP040750.1\|WP_138945294.1\|1250513_1252082_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|237797
NZ_CP040750.1\|WP_138945291.1\|1248911_1249616_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224059

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138945289.1\|1246322_1247588_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.71474e-51
NZ_CP040750.1\|WP_138945285.1\|1240608_1240893_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	1.14593e-05
NZ_CP040750.1\|WP_168223331.1\|1250169_1250466_-\|pyrimidine/purine-nucleoside-phosphorylase	gnl\|CDD\|377724	pfam06865, DUF1255, Protein of unknown function (DUF1255). This family consists of several conserved hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown.	8.41628e-42
NZ_CP040750.1\|WP_138947209.1\|1241680_1243165_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225080	COG2169, Ada, Adenosine deaminase [Nucleotide transport and metabolism].	1.0413e-55
NZ_CP040750.1\|WP_138945295.1\|1252784_1253636_-\|hydroxyethylthiazole-kinase	gnl\|CDD\|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	5.60683e-110
NZ_CP040750.1\|WP_085513978.1\|1241141_1241573_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	8.51704e-13
NZ_CP040750.1\|WP_138945284.1\|1240242_1240479_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	1.31255e-07
NZ_CP040750.1\|WP_138945288.1\|1245673_1246330_-\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.76214e-58
NZ_CP040750.1\|WP_138945290.1\|1247764_1248850_+\|FtsX-like-permease-family-protein	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	4.08051e-11
NZ_CP040750.1\|WP_138945283.1\|1239703_1240246_-\|HNH-endonuclease	gnl\|CDD\|379158	pfam13392, HNH_3, HNH endonuclease. This is a zinc-binding loop of Fold group 7 as found in endo-deoxy-ribonucleases and HNH nucleases.	8.46252e-10
NZ_CP040750.1\|WP_137243990.1\|1254308_1254992_-\|HAD-family-hydrolase	gnl\|CDD\|319828	cd07526, HAD_BPGM_like, subfamily of beta-phosphoglucomutase-like family, similar to Escherichia coli 6-phosphogluconate phosphatase YieH. This subfamily includes Escherichia coli YieH/HAD3 an 6-phosphogluconate phosphatase, which can hydrolyzed purines and pyrimidines as secondary substrates. It belongs to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), Saccharomyces cerevisiae phosphatases GPP1 and GPP2 that dephosphorylate DL-glycerol-3-phosphate, and DOG1 and DOG2 that dephosphorylate 2-deoxyglucose-6-phosphate. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.26836e-48
NZ_CP040750.1\|WP_138945286.1\|1243161_1243722_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	6.05874e-36
NZ_CP040750.1\|WP_138945296.1\|1253788_1254298_+\|DUF1622-domain-containing-protein	gnl\|CDD\|377914	pfam07784, DUF1622, Protein of unknown function (DUF1622). This is a family of 14 highly conserved sequences, from hypothetical proteins expressed by both bacterial and archaeal species.	8.52932e-23
NZ_CP040750.1\|WP_138945294.1\|1250513_1252082_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|237797	PRK14713, PRK14713, bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase.	0
NZ_CP040750.1\|WP_138945287.1\|1244099_1245470_+\|deoxyribodipyrimidine-photo-lyase	gnl\|CDD\|223492	COG0415, PhrB, Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair].	6.12048e-169
NZ_CP040750.1\|WP_138945291.1\|1248911_1249616_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	1.76922e-82

>NZ_CP040750.1|WP_138945287.1|1244099_1245470_+|deoxyribodipyrimidine-photo-lyase
MAAAPTIVWFRDDLRLADNPALHAAVELDAPILCLFVLDDSEALRPLGGASRWWLHHSLEALGDDIRGLGGTLLLRSGSAATIVPELAHSIGAGAVLWNRRYGAAEREIDAGIKSELKDAGLDARSFAANLLAEPWEIVTGQGQPYSVFTPFWKASLQRYAANPPRHPLPAPSALTAMADPPSGDELGSWNLLPTKPDWAAGLREQWTPGEAGADERLADFIDGGVTGYAEDRDFPAQPSTSGLSPHLRFGEISSPQIWHAARDGRRHLGDDGATFLKELGWRDFAYHCLFAFPDLATRNWRQAFDRFPWPDVDQDAFEAWTAGRTGIPLVDAGMRELWATGTMHNRIRMVTASFLTKNLLIHWKLGEDWFWDTLVDADPASNPFNWQWVAGSGFDASPYFRIFNPERQRERFDADDAYIKRWVPEFGTPDYPEPIVDLGETRQAALAAYEHVKGA
>NZ_CP040750.1|WP_138945286.1|1243161_1243722_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MTTIISSTSARRDDGRAPAAQLTATSQTVDTPDGPFTILAREDGAVLSSGWSDDIGVMLERIRPTDRPGETVAGTVAAMDAVRAYYDGDLTAIDLVPVAQFGGPFRTHAWTVLRTIAAGHPVTYTEFAAASGRPSAVRAAASACATNAPALFVPCHRVLRTDGTLGGFAWGLDVKRSLLDREAALS
>NZ_CP040750.1|WP_138947209.1|1241680_1243165_+|helix-turn-helix-domain-containing-protein
MDFAERYRAIQARDQRFDGQFITAVSSTGIYCRPSCPARTPKPENVTFYATSAAAHEAGFRACKRCLPEAVPGTPAWNLGNDVAARSMRLIADGVVEREGVPGLASRLGYSSRHLTRILSAELGAGPLALARAHRAQGARQLLTGTDLPFGDIAFAAGFSSIRQFNDTMREVFELTPGELRAKHRTVGEHAPGSITLSLPFRRPFDAAGVFAWLAPRAVDGVELAGPDHYARLLALPGGTAWFEVRQVGDDLRLTAEVTDLADLPVLVSRVRRLFDLDADPTSADAVLAADPRLATSVAATPGIRLPGAVDPEEMLVRAMVGQQITVAAARTQLRRLADEVSTTVPERHGLHRLFPRAAQIADGGEAALVGPRARIDSLLGVARALVSGELTIGFGDDRDELRTRLLAMKGIGPWTADYVSMRVLGNPDAFLPGDVAVRTGAGRLGLSSDARSLTAEADAFAPWRSYLCLHLWKAASTPAPSAAPSALEKGPAA
>NZ_CP040750.1|WP_085513978.1|1241141_1241573_+|MarR-family-transcriptional-regulator
MDERRLAIAAWESLFRAQVDVMRHISHDFPSHGISLNEYDVLHTMSREPDRRIRLRDLNSSVLLSQPSISRLVDRLVARGLVGKCPDPDDGRGTLVRMTDAGYDVYRAVAIAHGATIAERVTTSLSPQEMATLAALSDKLRGA
>NZ_CP040750.1|WP_138945285.1|1240608_1240893_+|helix-turn-helix-transcriptional-regulator
MSHSLDIKPATTNVRHEIAAAVRAHFAVRSTNDSKVARAIGKSQSWMSRRTNGDTPFDADDLGAIADLFGISYLELAQMPTGRPNPENPMQNSF
>NZ_CP040750.1|WP_138945284.1|1240242_1240479_-|helix-turn-helix-domain-containing-protein
MAKTTPAKRVIQELGGIYRFNRVSQKTAAARTGISASAISRRLNGDTSPTIDELFAMASAAGVNVRIEFLPAEAESVA
>NZ_CP040750.1|WP_138945283.1|1239703_1240246_-|HNH-endonuclease
MTTNTETPRRQPGRFEEPERNTVSDTHTVPRPTGIDNEVRAWDLPENWWNKVAITATCWLWTGAKNGNGYASVKSGNGGTALAHRMSYELFVGPIPEGLTIDHLCGIHRCINPTHLEPVTNAVNNRRRWEKVVKCPRGHELTADNVKTHTRKNGHTSQDCKRCAADASKRYRDRAKGKAA
>NZ_CP040750.1|WP_168223330.1|1238561_1238708_-|hypothetical-protein
MAQDIDWILALADEIGRRMDAGQLPPQDENGMYVMDGAARDAAEAVSS
>NZ_CP040750.1|WP_138945282.1|1238379_1238565_-|hypothetical-protein
MTFSADDLDEPNARHIESALRLAMAQIAAVERLAKLASKRAVPTVSAKELRRALAVRPTDV
>NZ_CP040750.1|WP_168223329.1|1238073_1238229_-|hypothetical-protein
MSKHYMSCDECDLTFWTTSPESGVRVMGEHKRVMHITPVPASAHAANGGAR
>NZ_CP040750.1|WP_138945288.1|1245673_1246330_-|response-regulator
MRDDATDAGEPRVIRVVVADDHPIVRAGLLAVLAPIADIEVVGTASTAAEAVAAAPGADLVLMDLSFGDGPTGIDATREIASLPGGPSVLVLTNYDSDADILGAIEAGAAGYLLKDAAPEDLIDGIRSAAGGNSVLGPAVATRLVARVSAPQQALSAREIEVLARAAEGLTNLEIAGRLHVGETTVKSHLAHIYTKLDVSNRSAAIAAAQRAGLFRTR
>NZ_CP040750.1|WP_138945289.1|1246322_1247588_-|sensor-histidine-kinase
MKHSALSPVFTGLQLGLHGLVTALIVLVIARSVSVGGQTALAAIVLAVVMLLTYAAGAILGGRVRRAVVATGGTDRATAPAGVRRGRVSVLVWLVLLSVEWVVLVLLSPDAAYLVFPLFFLYLHLLPRAVAVPAVVIATIAAVVAIGLHAGFSVGGVVGPLVGAAVAVAIGLGYEALAREAAERERLIAELVAAREELAERGRQAGKLAERERLAADLHDTVAQALSSIQLLLHAAERSAVEQPGTEQLRSHIGLARDAAATALAETRSLIDELSPPALTGATIADALGRLAETTTAESGTPVSTTVTGDAFVLGTPVTTALLRAAQSSLANVVRHAGASRADVTLTYLDEEVILDIDDDGAGFDPASVAERTAGGSFGMMSMRRRITELGGEVEVRSAPGAGTTITVRFAAPGVEGDVHA
>NZ_CP040750.1|WP_138945290.1|1247764_1248850_+|FtsX-like-permease-family-protein
MFVAWRDMRFATGRFVLIGAVVALITLLVGFLSGLTAGLANQNISAITGLGASSIVLAAPTDGEQATFADSAIDADAATTWAAVPGVDGVQELGISQTRMTTDDARTSVALFGISGDAVAGRAADVPTDGTVRLSRTAAEALHVSRGDTVSIGGSELEVGSVVDDQWYSHTPVVWTSLSEWRSLQAAQGSPGDGATALAITGNPSADAVTGAEQATGTVSKDVLSSLLAIGSFRSEIGSLLLMVAMLFGISALVIGAFFTVWTMQRAGDVAILKALGATTRRLSLDALGQALVLLVLGVGLGIGITAALGSAAGTALPFVLSPLTTLVPGVIMIALGLIGAAFALRSILSADPLTALGGNR
>NZ_CP040750.1|WP_138945291.1|1248911_1249616_+|ATP-binding-cassette-domain-containing-protein
MISLTDVTLTFPDGDHRVTAVDHATLTVPAGTVTALTGPSGSGKSSVLAVAAGLIRPDSGLVEVAGVDVTSLDRRAATDFRRTRLGIVFQQANLLPSLTALEQLCVLETLGGRASRADRTRTRERAAMLLAAVGLADQADKRPHQLSGGQRQRVNIARALMNEPDALVVDEPTSALDHERGSAIIELILELTATSGAATLLVTHDRSHLDRMDQVLVMEDGRLSAAADALALRS
>NZ_CP040750.1|WP_138945292.1|1249667_1250066_+|hypothetical-protein
MRRATRGLTVIAIVGAALGTSACTGGADSPSGQSSASEADVIAPVIVQLVDQDGRTVTVGLDNVVDLVAVDPTVWSAEVEDPSIAEYVPGGSRGGASFNPGLQPLEVGSTTVTLTNSSDDSTVVLTLEVVDS
>NZ_CP040750.1|WP_168223331.1|1250169_1250466_-|pyrimidine/purine-nucleoside-phosphorylase
MLTSNEYFDGNVKSIGFTTNEPGAESASVGVMEPGEYTFTTGKAEEMSVISGKLRVLLPNTSAWQDFGPDAQFSIPGSSSFQVEVEVTTAYLCRYLNI
>NZ_CP040750.1|WP_138945294.1|1250513_1252082_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MSAAEQTLTPASSSSNRVHGRRPVTTRETPRVLSIAGTDPTGGAGIQADLKSIAANGGYGMAVVTALVAQNTRGVRSVHTPPVGFLREQLDAVADDVVIDAVKIGMLGDVAIIHTVSTWLQETVTGPVVLDPVMVATSGDRLLHRDAEAAMRELLPHVDLVTPNLPELAVLADEPVATSWADALAQAERVSAQAGVIVLVKGGHLTGTAACPDALVDATGGLGGGRSLVEFDGLRVDTPNTHGTGCSLSSAMATLVARSGSWTEALGEAKSWLTSSLRHADALEVGSGNGPISHFAELWASAGMTSGRQDGAGILTGWWEDIAELRDRIDHLPFVTTLADGTLDPARFAWYLQQDAIYLRAYSRVLARASALAPTAEEQVFWATGAAGSIKAEMELHRTWLRTYAVSGMDVEPSATTTAYLDHLHAATVDGDYGRVVAAVLPCYWIYQDLGERLVDASHVEHPFAAWLDTYADPAFATANARAIEIVAGAAARADEAGRDTMRRAFLASAAHEEAFFAEPIR
>NZ_CP040750.1|WP_138945295.1|1252784_1253636_-|hydroxyethylthiazole-kinase
MSIRTPQQSAHPSTDDSSVGEFASASGDLLDRLRERTPLVQSITNAVVTNFTANVLLAIGAAPAMTDIPTEAGPFARIASGVLLNLGTPQAEQREAMVEAATAANDAGTPWVLDPVAVGFLPVRTALAAELLALRPTIVRGNASEIIALAGLGAGGRGVDSTDSVDSAVEAATAIARTSGAVVAISGPTDVITDGERIVRCSNGHAWLTLVTGGGCALGAVLAAFASLDDDRLLTTVAATTAYTVAAQLAAAESRGPGSFAPAFLDHLHLLDADTVRSLAVIA
>NZ_CP040750.1|WP_138945296.1|1253788_1254298_+|DUF1622-domain-containing-protein
MDFFELVTIVFEVAGVGAMVVGFVIAVTLSARLWWSTRDGARAFRMLRETIGSVILLGLEILVAADLVKTVTSTPSLTDALVLAIIVVIRTLLSFSLQIEIEGTLPWRRLATTGPQLFDRAVKRGGERTRRRAEEQDASASPDAAPAPIVTTQPVPDDEDGFPELRSRS
>NZ_CP040750.1|WP_137243990.1|1254308_1254992_-|HAD-family-hydrolase
MPVDYPDLVIFDCDGTLVDTERISVRVNLQLLNEVGGDYTEAEVRELFVGASLETYATLVEQRLGKPLEADWIQRWSDMFRGICERELEAVDGVVDALDGIAATGVPLCVASNGMLHDVVRNLGQVGIHDRFDGRIFSATDVAVGKPAPDLFLHAAADFDTAPERCAVIEDSVVGVLAARAAGMTVYAYAGGMTPAERLVGDGTHVFDDMRLLPDLIRDTWATSAAR

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Crispr_ID: NZ_CP040750_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_10

1492670-1492768

Orphan

Consensus_repeat	Method
TGCCAGCGCGGTGCGCTGACGTGAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_10

>merge|NZ_CP040750|10|1492670-1492768|CRISPRCasFinder
TGCCAGCGCGGTGCGCTGACGTGAGCGAGGGGTGACCGCCGCCAGCGCACCGCGCTGAAGGGGTCATCCGGGTGCCAGCGCGGTGCGCTGACGTGAGCG

>NZ_CP040750|10|10|1492670-1492768|CRISPRCasFinder
TGCCAGCGCGGTGCGCTGACGTGAGCG	AGGGGTGACCGCCGCCAGCGCACCGCGCTGAAGGGGTCATCCGGG
TGCCAGCGCGGTGCGCTGACGTGAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138945471.1\|1490859_1492653_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP040750.1\|WP_138945479.1\|1500201_1501698_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274522
NZ_CP040750.1\|WP_168223342.1\|1501815_1502700_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378820
NZ_CP040750.1\|WP_138945467.1\|1486341_1486587_+\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	gnl\|CDD\|372613
NZ_CP040750.1\|WP_138945476.1\|1497884_1498385_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945472.1\|1492926_1494405_+\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NZ_CP040750.1\|WP_138945468.1\|1486583_1487030_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350245
NZ_CP040750.1\|WP_138945477.1\|1498457_1499003_-\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|379311
NZ_CP040750.1\|WP_138947221.1\|1488722_1489493_-\|D-alanyl-D-alanine-carboxypeptidase-family-protein	unknown	unknown	gnl\|CDD\|350624
NZ_CP040750.1\|WP_138945473.1\|1494541_1495555_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224525
NZ_CP040750.1\|WP_079706442.1\|1495633_1496500_-\|site-specific-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|334588
NZ_CP040750.1\|WP_168223341.1\|1485040_1486216_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|283837
NZ_CP040750.1\|WP_138945474.1\|1496570_1496864_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379642
NZ_CP040750.1\|WP_138945475.1\|1496924_1497845_+\|polyphosphate-kinase-2	unknown	unknown	gnl\|CDD\|213852
NZ_CP040750.1\|WP_138945478.1\|1499094_1500144_-\|lipoate--protein-ligase-family-protein	unknown	unknown	gnl\|CDD\|223173
NZ_CP040750.1\|WP_138945470.1\|1489655_1490750_+\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|223730
NZ_CP040750.1\|WP_138945463.1\|1482607_1483276_+\|FCD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224715
NZ_CP040750.1\|WP_138945462.1\|1479688_1481044_-\|NADP-specific-glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|181834
NZ_CP040750.1\|WP_138945464.1\|1483396_1484359_-\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|237013
NZ_CP040750.1\|WP_138945469.1\|1487058_1488678_+\|alpha-D-glucose-phosphate-specific-phosphoglucomutase	unknown	unknown	gnl\|CDD\|236050

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138945471.1\|1490859_1492653_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.45272e-65
NZ_CP040750.1\|WP_138945479.1\|1500201_1501698_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|274522	TIGR03329, Phn_aa_oxid, putative aminophosphonate oxidoreductase. This clade of sequences are members of the pfam01266 family of FAD-dependent oxidoreductases. Characterized proteins within this family include glycerol-3-phosphate dehydrogenase (1.1.99.5), sarcosine oxidase beta subunit (1.5.3.1) and a number of deaminating amino acid oxidases (1.4.-.-). These genes have been consistently observed in a genomic context including genes for the import and catabolism of 2-aminoethylphosphonate (AEP). If the substrate of this oxidoreductase is AEP itself, then it is probably acting in the manner of a deaminating oxidase, resulting in the same product (phosphonoacetaldehyde) as the transaminase PhnW (TIGR02326), but releasing ammonia instead of coupling to pyruvate:alanine. Alternatively, it is reasonable to suppose that the various ABC cassette transporters which are also associated with these loci allow the import of phosphonates closely related to AEP which may not be substrates for PhnW.	2.39329e-56
NZ_CP040750.1\|WP_168223342.1\|1501815_1502700_-\|alpha/beta-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	6.95644e-42
NZ_CP040750.1\|WP_138945467.1\|1486341_1486587_+\|ribbon-helix-helix-protein,-CopG-family	gnl\|CDD\|372613	pfam13467, RHH_4, Ribbon-helix-helix domain. This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.	0.000224863
NZ_CP040750.1\|WP_138945472.1\|1492926_1494405_+\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NZ_CP040750.1\|WP_138945468.1\|1486583_1487030_+\|PIN-domain-containing-protein	gnl\|CDD\|350245	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC25, VapC29, VapC33, VapC37, and VapC39 toxins. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.32716e-39
NZ_CP040750.1\|WP_138945477.1\|1498457_1499003_-\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	1.38438e-05
NZ_CP040750.1\|WP_138947221.1\|1488722_1489493_-\|D-alanyl-D-alanine-carboxypeptidase-family-protein	gnl\|CDD\|350624	cd14852, LD-carboxypeptidase, L,D-carboxypeptidase DacB and LdcB, and related proteins. This L,D-carboxypeptidase family includes LdcB LD-Carboxypeptidase from Streptococcus pneumoniae, Bacillus anthracis, and Bacillus subtilis, and L,D-carboxypeptidase DacB from Streptococcus pneumonia and Lactococcus lactis. These enzymes are active against cell-wall-derived tetrapeptides and synthetic tetrapeptides lacking the sugar moiety but are inactive against tetrapeptides terminating in L-alanine. L,D-carboxypeptidase DacB plays a key role in the remodeling of S. pneumoniae peptidoglycan during cell division. It adopts a zinc-dependent carboxypeptidase fold and acts as an L,D-carboxypeptidase towards the tetrapeptide L-Ala-D-iGln-L-Lys-D-Ala of the peptidoglycan stem. This family also includes vanY D-Ala-D-Ala carboxypeptidase which is vancomycin-inducible and penicillin-resistant. VanY hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors; it is insensitive to beta-lactams. All these enzymes belong to the MEROPS family M15 subfamily B.	2.16879e-67
NZ_CP040750.1\|WP_138945473.1\|1494541_1495555_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.69387e-95
NZ_CP040750.1\|WP_079706442.1\|1495633_1496500_-\|site-specific-DNA-methyltransferase	gnl\|CDD\|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	4.4209e-47
NZ_CP040750.1\|WP_168223341.1\|1485040_1486216_+\|hypothetical-protein	gnl\|CDD\|283837	pfam06259, Abhydrolase_8, Alpha/beta hydrolase. Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile.	7.75406e-10
NZ_CP040750.1\|WP_138945474.1\|1496570_1496864_+\|N-acetyltransferase	gnl\|CDD\|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	7.00493e-22
NZ_CP040750.1\|WP_138945475.1\|1496924_1497845_+\|polyphosphate-kinase-2	gnl\|CDD\|213852	TIGR03707, PPK2_P_aer, polyphosphate kinase 2, PA0141 family. Members of this protein family are designated polyphosphate kinase 2 (PPK2) after the characterized protein in Pseudomonas aeruginosa. This family comprises one of three well-separated clades in the larger family described by pfam03976. PA0141 from this family has been shown capable of operating in reverse, with GDP preferred (over ADP) as a substrate, producing GTP (or ATP) by transfer of a phosphate residue from polyphosphate. Most species with a member of this family also encode a polyphosphate kinase 1 (PPK1). [Central intermediary metabolism, Phosphorus compounds].	2.83125e-159
NZ_CP040750.1\|WP_138945478.1\|1499094_1500144_-\|lipoate--protein-ligase-family-protein	gnl\|CDD\|223173	COG0095, LplA, Lipoate-protein ligase A [Coenzyme metabolism].	6.80661e-58
NZ_CP040750.1\|WP_138945470.1\|1489655_1490750_+\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	8.66871e-28
NZ_CP040750.1\|WP_138945463.1\|1482607_1483276_+\|FCD-domain-containing-protein	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.08347e-39
NZ_CP040750.1\|WP_138945462.1\|1479688_1481044_-\|NADP-specific-glutamate-dehydrogenase	gnl\|CDD\|181834	PRK09414, PRK09414, NADP-specific glutamate dehydrogenase.	0
NZ_CP040750.1\|WP_138945464.1\|1483396_1484359_-\|prephenate-dehydratase	gnl\|CDD\|237013	PRK11898, PRK11898, prephenate dehydratase; Provisional.	7.32087e-88
NZ_CP040750.1\|WP_138945469.1\|1487058_1488678_+\|alpha-D-glucose-phosphate-specific-phosphoglucomutase	gnl\|CDD\|236050	PRK07564, PRK07564, phosphoglucomutase; Validated.	0

>NZ_CP040750.1|WP_138945471.1|1490859_1492653_+|MFS-transporter
MSSSSPASTEPSGSAPVLSHRQILFIIFGLMAGMFLSALDQTIVGTSMRTIADDLDGMALQAWVTTAYLITSTVSTPIYGKLSDIFGRRPLFIIAISIFLIGSLLAGMSGSMYELAIFRAIQGLGAGGLMALPLTIMGDMLAPRERAKYQGYFLAVFGVSSVIGPLIGGLFAGAPELLFITGWRWVFLINLPIGVIALAIVLRFLHIPHTRHSVRIDWWGAATVVLAVVPLLLVAEQGRIWGWASAGSIACYAIGVAGIIGFILVERAMRDDALIPLKLFKNSTFRVATILGVLVGFGMFGAMMTVPLFLQLVEGATPTESGLLMLPMILGLMISSIASGQIIARTGKYKAFPIVGTFLLLSGFFYFSFATADKPVWWMMGGMLLVGLGLGQLMQTLTIASQNAVEARDIGVATSSSTFFRQIGGTLGTAVIFSVLYTRLPDTIGAAFKDPTLLANAQAAAQDPAVLSDPANTGILDVLSKVQSGGSAGSALDGDTSFLVGANHDLAAPFLTGFADATVTVFWVSFAVVAVAFVLSWFLKAPPLRAKSALQERTDAQAAEDAEDELSLAAQRAAELAGSQLSPDTASNRVVDPSARR
>NZ_CP040750.1|WP_138945470.1|1489655_1490750_+|alpha/beta-hydrolase-fold-domain-containing-protein
MTAGTPAHHAPTHRKRPRFRRLLTAAAVVIGLGLVVAVIAAITPWPSALLIRSVFERGGAATVAEMEPYVPDTKLTEFRDITYAAPSGGRPQVDTTLDVFTPAAGTEPLTTIVWIHGGAWISGEKGNVEPYLRILAAAGYTTIAVNYTIAPEAVYPTAVNQLNDALAYISEHAAEWNGNPDRLVLAGDSAGSQLASQLAVLTTNPDYATLSGMTPGIEADQLVGAILNCGVYDLPAMAELDGIGAWGLQTALWAYAGTKDWSETSTGTLMSTVDFVTADFPPTFITGGNGDALTWLQSVPMSRALEDAGVDVTKLFWAADHEPALPHEYQFHLDLDDAHVALTATLDYLAALDANLDAAPTTTP
>NZ_CP040750.1|WP_138947221.1|1488722_1489493_-|D-alanyl-D-alanine-carboxypeptidase-family-protein
MAAALAILLVVLVVNIAGGATPTPAAATKTPSATPSVTPTPTPTPTPTETVPVAPPAPPAFDKAAYSIDDPLSPWVVVNKTRPLNPVDYTPPDLVSVPVAHTWDPLLRAEAAAAIVQLFDTASAEAGLSLASNSAYRSYSSQVSVYDSEPDDSTTARPGYSEHQTGWTMDIGAESGNCSLNTCFGDTAEGQWLAANAYRFGFLLRYPADKVDVTGFSFEPWHYRYIGVPLATEMHNTGVTTLEEFFGLPAAPGYLS
>NZ_CP040750.1|WP_138945469.1|1487058_1488678_+|alpha-D-glucose-phosphate-specific-phosphoglucomutase
MNDRAGTPATEADLIDVPSLIDAYYTLKPDVSIPEQRVVFGTSGHRGSSLNTAFNQDHIAATTQAIVEYRAGQGITGPLFIGSDTHALSGPAQTTALEVLVANGVRVLVDEFDDFVPTPALSHAILKYNAEGNGDQADGIVVTPSHNPPADGGFKYNPPHGGPADSDATSWIANRANELIAGGLHDVKMAEPSAVETYDFRGNYVDDLKHIINLDAIKRSGIRIGADPLGGASVHYWQAIADRYEIDLTVVNPHVDPAWAFMTLDWDGKIRMDPSSPSAMAALVARRDEFDLLTGNDADADRHGIVTPDAGLMNPNHYLAVAIDYLYANRPGWRDDAAVGKTLVSSSVVDRVAESLGRRLWEVPVGFKWFVPGLVDGSVGFGGEESAGASFLRFDGSVWTTDKDGILLCLLAAEILAVTGKTPSVLYRELTERFGDPVYERVDAAASKEQKARLGKLDGDAITATELAGDPIVAKLSHAPGNDAAIGGVKVVTEHAWFAARPSGTEDVYKIYAESFKGAEHLKLVQAEAKQIVDAALGA
>NZ_CP040750.1|WP_138945468.1|1486583_1487030_+|PIN-domain-containing-protein
MKVPDVNVLVGAFRDDDPNHLALVRWLESAVAADEPLGVSDSVLAAYVRIVTNRRIFDPPTPLLQALESADDLRRADGVRPVHPGPSFWRLFVRLCQESGVAGPQVADAAHAALAIEHRATFVTLDRDFARFPDLRWESPLATGQAPS
>NZ_CP040750.1|WP_138945467.1|1486341_1486587_+|ribbon-helix-helix-protein,-CopG-family
MRTTIRLADEFYEAVREHASQEGKTVTAYIEEALRAKLAAAATPPEREPYKVVPFRGGRGPRPGIDLTNNAQLQDIMDGLE
>NZ_CP040750.1|WP_168223341.1|1485040_1486216_+|hypothetical-protein
MDRAHPGVPRVAHHRVPGDHRQPRGCRLHGPGDGQRLPPRRPPRRHRGELPLADGEQRPGRRAGGLGGARHDPVAPGRDQATRRPVHAGRDRRPPPARVPHHPAGGRLRTPRVAVAVGDVDTAAYVTVLVPGMNSSALELDDYLRGAKRIQTAAADSAVILWIGGHSPSALEVPSNDRAVEGAPLLAGVLAGYDAVRSAHGVVSQLSVVAHSYGTATASLALASGDYHVDDFVMLGSAGIPTEIGIDDLHIPASRVYASQASADTLAGLGQLLSGRADPATSSWGATTFGSDGLTLGDGDHLGAVDGHNAVGSSNADDRGKYLGPATESLYAIQRIVTGQGYAVADLTTPGSSHQRASVPDAAGAGAGTSTTNTSTTASASASAAALLATR
>NZ_CP040750.1|WP_138945464.1|1483396_1484359_-|prephenate-dehydratase
MPAAPADDALRSYSFLGPSGTFTEVALGQVEEARGQIWKPVSNVGEALGDVLEGRSTAAVIAIENSVDGGVSVAQDALATMPGLRIVGEVLVPVNFVLVARPGTRLEHVSVVNAHPVAYGQCHLWLDAKLPSHGHIPASSNVAAAASLLDGTSTADAAVAPPGIVNHYDLDVLAENIGDNPNAVTRFVVVSRSREIPARTGADKTSLIVELPNDESGSLLGMLEQFSTRGVNLSLIESRPIGDALGRYRFVIDALGHIEDERMADALLGLRRFSPNVIFLGSYPSADRTAVDYHSRYNDEVFIEARDWLRGLLSAEPLDD
>NZ_CP040750.1|WP_138945463.1|1482607_1483276_+|FCD-domain-containing-protein
MSTPTQTTQLYERLRGAILTLDLAPGQPLTERGLEQRFAASRTPVRAALTRLEAEGLARRDGRGWIVAPIDLEEIGLIAEVREALETGGVRLAAERASEAQLAAIRTLLDEPRPDDGHTVLRVGGDFHEELAALSANHLLAEGVHGAMVRLARTRWLEVRTPEAREQAASEHRAILDAVAARDPERAAELVARHIRGTNERLIASLTADQRRLRGHGVDIVS
>NZ_CP040750.1|WP_138945462.1|1479688_1481044_-|NADP-specific-glutamate-dehydrogenase
MTGTTTSTDPVHAVAEAALRRNAGEPEFHQALLEVLESIRPALDEHPEYLEAGVLERLVEPERQVVFRVPWTDDRNRVQVNRGFRVQFNSALGPYKGGLRFHPSVNLSIVKFLGFEQIFKNALTAQGIGGAKGGSDFDPHGRSDAEIMRFCQSFMNELYRHLGEHTDVPAGDIGVGAREIGFLFGQYRKITNRHESGMFTGKGVGWGGAEVRTEATGYGTVFFVDEMLAVDGRGVEGKRVIVSGSGNVATYAIEKVHQLGGTAVTASDSSGYVVDDAGIDLELLKQIKEVERGRISEYAARRQGAHFVAGGSVWDVPGEIALPSATQNELHERDAIALVKHGVIAVAEGANMPSTPEAVRVFQQAGVLFGPGKAANAGGVATSALEMSQNAARQRWSFDDSEVKLRGIMHGVHRAAYEAAERYGRPGDYVVGANTAAFVKVADAMLAQGVI
>NZ_CP040750.1|WP_138945472.1|1492926_1494405_+|beta-glucosidase
MGVHPATRSFDDARPQPTTRPALILPPFIWGSATAAAQVEGAAHEDGKEDSIWDAFARVPGAIANGDDLEVAVDHYHRTAGDVAIMSELGLDAYRFSTSWARIKPGDRDVNPAGLDFYSRLVDQLLDAGILPWLTLYHWDLPQALEEQGGWTNRDTALRFVDYAEATYEALGDRVRHWTTFNEPFCSSLLGYAVGVHAPGRRDEAAALAAIHHQHLAHGLATTRLRELGAEQIGITLNLTNAIPADPTDPADIDAARRVDGIMNRIFLEPIVLGEYPADVAQDLEGLGLDTLVHDGDLETTSAPIDFLGVNHYHDDLVSGHPDDSGADGGHSGATEREAGSPWLASPDISFPSRGLPRTAMDWEVHPAGLRTLLVRLGREYPTLPPLYVTENGAAYDDVVAEDGRIHDVDRDAFIQDHIDQVELAIADGADVRGYFVWSLLDNFEWAYGYDKRFGIVRVDYDTQERTIKDSGLAYARRIAASRVVPAVAELP
>NZ_CP040750.1|WP_138945473.1|1494541_1495555_+|substrate-binding-domain-containing-protein
MMQSGQGAPTLEMVAARAGVSRATVSRVVNGSPKVTAEVVAVVNEAIAALDYVPNRAARSLASRRTQVIALVVPESTARVFSDPFFASVVQGVALELAETDYTLNLLIASEANSEKTRRYLLGGNVDGALVVSHHSGDHSYTRLGQELPIVFGGRPMGADVVDSTYVDVDNVEGARTAARHLIEAGRTRIATIAGRQDMPGGVDRLAGWRAELELAGLPHDLVEVGDFSPADGAAAMRRLLARGVPIDGLFAANDQMAAGAYSVIREAGLTIPGDIAVVGYDDDRYGETAAPPLTTIAQSPVDLGAEMARVLVRRLAGEPVERVTMMPTRLVPRASV
>NZ_CP040750.1|WP_079706442.1|1495633_1496500_-|site-specific-DNA-methyltransferase
MSLAAAADEVPLRWTPDGPDLVLEGDNLDVVAQLPDESFTLIYLDPPFNTGRVQRRHSSTSVRTAETGVNRFAGFKGQAYERIRGDLRRFDDAFDDYWGFLEPRLVEAWRVLAADGTLYLHLDYREAHYAKVLLDALFGRECFLNEIIWAYDYGAKAQSRWPTKHDTILVYVKDPKGYHFDNATVDREPYMAPGLVTAEKAARGKLPTDVWWHTIVSPTGREKTGYPTQKPEGILRRIVQASSREGDWVLDFFAGSGTTGAVAKALGRRYVLVDENPQALEIIRARLS
>NZ_CP040750.1|WP_138945474.1|1496570_1496864_+|N-acetyltransferase
MTTEFTNETDAQRYTMHVDGQLVSVVDYRISGDSISFPRTFTTPPFRGKGYAGELVTYAVDDVEQHSERRIVPMCWYVGEWFDAHPERQDLLTRSAG
>NZ_CP040750.1|WP_138945475.1|1496924_1497845_+|polyphosphate-kinase-2
MQQLVSHYAPPPALDQVDGYQVVDVDDDDPILLDAAGSHIDTWREGYPYAERMSREQYESDKRLLQIELLKLQNWIKANDRRLVVVFEGRDAAGKGGTIKRFTEHLNPRGARVVALEKPTTRESTQWYFQRYVQHLPAAGEIVLFDRSWYNRAGVERVMGFCNPAQYDEFMRQAPLFEQMLVGDGVDLVKFWFSVSADEQRTRFAIRQVDPVRQWKLSPMDLASLDKWGDYTRAKEAMLEATDTADAPWTIVKSNDKKRARVEAMRHVLHRFDYDNKDHEVVGTPDTNIVGPAASVYERGERNVGD
>NZ_CP040750.1|WP_138945476.1|1497884_1498385_+|hypothetical-protein
MQPNPSPLRRLTSSSAIYGTVVYAGLVGASSVYEEDDVEQVLITSALTLIVFWLAHVYSAALAHHGDDRHEALVTLGASIRHGFQESSGMLLSAVLPTIPLVFGVAGVLSHEHAVILALQVSTLMLFVLGCAAFVVRGSRWWWCLLGGVATALFGIVIILLEAGTH
>NZ_CP040750.1|WP_138945477.1|1498457_1499003_-|HEAT-repeat-domain-containing-protein
MTAQNETPDPSTPATQASLEQRLADAVAAESETRVVERCVSLLAGRYEGEDFLRVVGGHHAEGILGGAPALYWPELWGTRALLHVWDDSATAPVVGALGNQAWRVREMAARVCAERRIGDVAAIAPLLSDDHARVRAAGARTLAVVGGDNAKPLLEALLRDPDREVRRAAQQSAKALAARR
>NZ_CP040750.1|WP_138945478.1|1499094_1500144_-|lipoate--protein-ligase-family-protein
MHGEYKVPGGKLVVVDLEVVDDRIADFRLAGDFFLEPDDALALIDRAVTGLPATTDAAGLAAAIRGALPEDAVLLGFTPEAVATAIRRSLAKATGWGDYDWQLIHEGSVSPQLHLALDEVLTNEVGEGRRGPTLRIWEWDQSAVVIGSFQSLKNEVDLDNAKANGFEVVRRVSGGGAMMMQRGGIITYSLYVPAELVNGMTFADSYAYLDDWVLVALRSLGIEATYQPLNDITSPSGKIGGAAQKRLGNGAVLHHVTMSYDMDGELMTQVLRIGREKLSDKGTTSAAKRVDPLRSQTGLSRAEIIDRMKDTFVEITGATPGHVTAAERAAAEQLVADKFATDAWLTRVP
>NZ_CP040750.1|WP_138945479.1|1500201_1501698_-|FAD-dependent-oxidoreductase
MAGHPVTSPEAAGYSRGTHTRRRGDPVTSDGPTYSHRRRNSAERIARSLAGASTVPYWLDSPDRPTPEPRLVGQITADLLVVGGGYSGLWTALIAKEADPSRDVVLVEGKEVGWAASGRNGGFFEESLTHGVDNGERHFADELPELDRLADENFDEFVATLDRLGIDAEFEHTGVLTVATEPHQVDALREVSGDGVFLDREAVQALVHSPVYLAGQREWKSTALVHPAKLAWGLKRACIELGVRVFEHTPATRLRRSGDGVAVTTKQGGVQARQVALATNGFPSLLKRTELLTIPVYDYVLMTEPLSAEQLESIGWTDRFGIADSSREFHYSRRSADDRILYGGFDAVYHRGGRIRPEHDQRRETFETLADHFFTTYPQLDVRFTHAWGGMIDMCSRLSAFQGTALGGRVAYSAGFTGLGVGATRFGARVMLDLLSGESTELTRLKMVRSKPIPIPPEPIANPAIQTVRRAVARSDANEGRDGLLLKVMDRFGIGFDS
>NZ_CP040750.1|WP_168223342.1|1501815_1502700_-|alpha/beta-hydrolase
MSEQTPPPVDDANRPVEPRPYATETIVDDDGVTVYVYLWEVPNPRAVVHIAHGAGEHALRYGRLAARLNDAGYTVAADDHRGHGRTGLEHLGLGKLGPRTTRGAIDSVAAVGRYLRTRFPESRLALLGHSWGSLMAQKVVAEHDLYELLILSGTSLAMPGVINAGDLNKRWRKTGKTGLEWLNRDPAAWAAFAADERNFDIGVTPVWNPIQAFAFLGRPPKRLPRAVPVLILGGSDDSLGGVRGLTLLRDAYVKRSKLKDVTLVIYPEARHEIFNELNREDVERDVVEWLDKRT

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Crispr_ID: NZ_CP040750_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_11

2007243-2007349

Orphan

Consensus_repeat	Method
CGGTTCCTGAGCCTGTCGAAGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_11

>merge|NZ_CP040750|11|2007243-2007349|CRISPRCasFinder
CGGTTCCTGAGCCTGTCGAAGGGCAGTGACCGACGGTCCGGTCCCTGAGCCTGTCGAAGGGTGGTGACCGGCGGCCGTGTTGCCGGTCCCTGAGCCTGTCGAAGGGC

>NZ_CP040750|11|11|2007243-2007349|CRISPRCasFinder
CGGTTCCTGAGCCTGTCGAAGGGC	AGTGACCGACGGTCCGGTCCCTGAGCCTGTCGAAGGGTGGTGACCGGCGGCCGTGTTGC
CGGTCCCTGAGCCTGTCGAAGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138945816.1\|2005514_2006240_-\|3-oxoacid-CoA-transferase-subunit-A	unknown	unknown	gnl\|CDD\|224702
NZ_CP040750.1\|WP_138945818.1\|2008337_2009228_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP040750.1\|WP_138945809.1\|1997205_1998171_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP040750.1\|WP_138945814.1\|2002880_2003450_+\|deaminase	unknown	unknown	gnl\|CDD\|334719
NZ_CP040750.1\|WP_138945819.1\|2009317_2012791_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143443
NZ_CP040750.1\|WP_138945817.1\|2006434_2007184_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224332
NZ_CP040750.1\|WP_064293956.1\|2004816_2005512_-\|CoA-transferase-subunit-B	unknown	unknown	gnl\|CDD\|188219
NZ_CP040750.1\|WP_138947258.1\|2014090_2015095_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381377
NZ_CP040750.1\|WP_138945823.1\|2015670_2016771_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945811.1\|1999026_2000355_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|181163
NZ_CP040750.1\|WP_138945810.1\|1998229_1999030_+\|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|143605
NZ_CP040750.1\|WP_138945820.1\|2013046_2013622_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945825.1\|2018014_2019772_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368264
NZ_CP040750.1\|WP_138945815.1\|2003647_2004820_-\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|180261
NZ_CP040750.1\|WP_138945821.1\|2013631_2013895_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945813.1\|2001369_2002797_+\|beta-glycosidase	unknown	unknown	gnl\|CDD\|307945
NZ_CP040750.1\|WP_138945822.1\|2015192_2015660_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240035
NZ_CP040750.1\|WP_138945812.1\|2000463_2001180_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|184971
NZ_CP040750.1\|WP_079000486.1\|2007359_2008229_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|381314
NZ_CP040750.1\|WP_168223361.1\|2016767_2017925_-\|acyltransferase	unknown	unknown	gnl\|CDD\|224748

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138945816.1\|2005514_2006240_-\|3-oxoacid-CoA-transferase-subunit-A	gnl\|CDD\|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	3.78104e-103
NZ_CP040750.1\|WP_138945818.1\|2008337_2009228_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.73552e-35
NZ_CP040750.1\|WP_138945809.1\|1997205_1998171_+\|EamA-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.36558e-16
NZ_CP040750.1\|WP_138945814.1\|2002880_2003450_+\|deaminase	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	1.6653e-14
NZ_CP040750.1\|WP_138945819.1\|2009317_2012791_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143443	cd07125, ALDH_PutA-P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA. The proline catabolic enzymes of the aldehyde dehydrogenase (ALDH) protein superfamily, proline dehydrogenase and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH, (EC=1.5.1.12 )), catalyze the two-step oxidation of proline to glutamate; P5CDH catalyzes the oxidation of glutamate semialdehyde, utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA) These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis. In certain prokaryotes such as Escherichia coli, PutA is also a transcriptional repressor of the proline utilization genes.	0
NZ_CP040750.1\|WP_138945817.1\|2006434_2007184_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	7.42431e-50
NZ_CP040750.1\|WP_064293956.1\|2004816_2005512_-\|CoA-transferase-subunit-B	gnl\|CDD\|188219	TIGR02428, 3-oxoadipate_CoA-transferase_subunit_B, 3-oxoacid CoA-transferase, B subunit. Various members of this family are characterized as the B subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The A subunit represents a different clade in pfam01144.	1.66514e-119
NZ_CP040750.1\|WP_138947258.1\|2014090_2015095_-\|aldo/keto-reductase	gnl\|CDD\|381377	cd19151, AKR_AKR14A2, Salmonella enterica aldo-keto reductase (AKR) and similar protein. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).	0
NZ_CP040750.1\|WP_138945811.1\|1999026_2000355_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|181163	PRK07906, PRK07906, hypothetical protein; Provisional.	0
NZ_CP040750.1\|WP_138945810.1\|1998229_1999030_+\|carbon-nitrogen-hydrolase-family-protein	gnl\|CDD\|143605	cd07581, nitrilase_3, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	6.79892e-112
NZ_CP040750.1\|WP_168223361.1\|2016767_2017925_-\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	3.33805e-28
NZ_CP040750.1\|WP_138945825.1\|2018014_2019772_+\|hypothetical-protein	gnl\|CDD\|368264	pfam05048, NosD, Periplasmic copper-binding protein (NosD). NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ). This region forms a parallel beta helix domain.	9.56961e-05
NZ_CP040750.1\|WP_138945815.1\|2003647_2004820_-\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	1.73853e-178
NZ_CP040750.1\|WP_138945813.1\|2001369_2002797_+\|beta-glycosidase	gnl\|CDD\|307945	pfam02055, Glyco_hydro_30, Glycosyl hydrolase family 30 TIM-barrel domain.	2.64845e-40
NZ_CP040750.1\|WP_138945822.1\|2015192_2015660_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240035	cd04679, Nudix_Hydrolase_20, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	4.67122e-49
NZ_CP040750.1\|WP_138945812.1\|2000463_2001180_-\|NUDIX-domain-containing-protein	gnl\|CDD\|184971	PRK15009, PRK15009, GDP-mannose pyrophosphatase NudK; Provisional.	7.7325e-56
NZ_CP040750.1\|WP_079000486.1\|2007359_2008229_-\|oxidoreductase	gnl\|CDD\|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	2.11171e-145

>NZ_CP040750.1|WP_138945817.1|2006434_2007184_+|helix-turn-helix-domain-containing-protein
MRGAQVVSRVSRILKIVSEHPGGASSSAVAAAAGLTRPTAHRLLASLAAEGFLDHDARAARWHLGPELFLLGSLAAERYDVAELARESVRILAHESGESAFLSVRRGFETVCLLREEGSFPVRSFVLTEGVRFPLGVASAGLAILAFSSDEEIDDYLGRADLVERWGEAHAADRVRERTRETRERGYAVNPALILEGSWGMGAAVFDAAGKPAWALSLTGIESRFRPERQAFLGGLLLEQAHELSKRLR
>NZ_CP040750.1|WP_138945816.1|2005514_2006240_-|3-oxoacid-CoA-transferase-subunit-A
MTKHWSSAAEALHEVVRDGATIAVGGFGLSGNPTDLIEALRDTGATDLTIVSNNMGVDGKGLGILLENRQVRKVVASYVGENKLFAKQFLDGELEVEFTPQGTLAERLRAGGAGIAGFYTKTGVGTPVAEGKPTEVFDGETYVLERGIVADVALVHAFRADSEGNLVFRHTARNFNPIVATAGRLTIAEAEEVLEDGYLDPNTVVTPGIFVQRIVTATPRVKDIEQRTVRPAAAATTPAGA
>NZ_CP040750.1|WP_064293956.1|2004816_2005512_-|CoA-transferase-subunit-B
MMWTRDDMAAIAATELRDGEYVNLGIGIPTLVANHVPPGVHVTLQSENGLLGMGPFPIEGEEDADLINAGKQTVTLLEGGSYFDSATSFGMIRGGHVQLAILGALQVSGAGDLANWTIPGKLVKGMGGAMDLVAGTPRVVVVTEHVAKDGSPKIVEQCDLPLTGVGVVDRIISDRAVFDIVEGALVLRAFAPDTSVAELRTLTGAEFSVELDPTTTGEVPTAPATPQEAHA
>NZ_CP040750.1|WP_138945815.1|2003647_2004820_-|acetyl-CoA-C-acyltransferase
MSTVIVGYARTPFVKFNGAFASVPATELGAHAIRAALSRAGVDAADVQQVIAGQVLQGAAGQNPARQSAVGADIPFTVPAITVNAVCLSGMEAIVSGTRLIDAGEVDVVVALGQESMSLAPHAWSGSRAGKRYGAIELVDTLDHDGLTDAFEHRSMGSSTEERNGSLGIARPEQDAWAAGSHQRLAAAADVQAEEIEPFSVPGRKGPTIVSADDGLRADTTAESLAGLRPAFGGEGTITAGNSSQITDGAAAVVLMSEEAAAARGLTPIARVVAHALVAGPDVSLHAQPSNAIVAALAKTSHTTGDLAAVEINEAFAAVSVHSTDELGVDPAIVNANGGAIALGHPIGASGTRIVGHLARRLAAAGSGSIGAAGICGGGGQGSAIILEAV
>NZ_CP040750.1|WP_138945814.1|2002880_2003450_+|deaminase
MGRLIYSAISSLDGYLADEEGHFDWSAPDAEVHAFVNELSRPIGTYLFGRRMYEIMTFWETADELPDEPREIADFAALWLAADKVVYSTSLDAVSTARTTLERSFDPEAVRRWKAESDRDLSVGGPHLAAEAMAAGLVDEVQLFLSPVIVGGGLRALPVNLRRRLELVDERRFEAGVVHLRYTVTGEPV
>NZ_CP040750.1|WP_138945813.1|2001369_2002797_+|beta-glycosidase
MTSSSPASSPVASGGTTPSARSVSWVVTTQDAPWQEQEPLGFGRLAGMPNVMVDVTNPQQTVDGIGGCFNELGWTALGLLPEADREGILSDLFTPGAGLNLSLCRMPVGANDFSTDWYSYDEVDGDFDLEHFSIDHDRATLVPFIQAAQRYQGDLRLWASPWSPPTWMKTNGHYAAARPWPGSGVDNGIRDDQLGSEGTDLFILEDRYLEAYARYFARFVEAYGEEGIRVEMVMPQNEFNSAQVFPSCVWTAEGLARFIAVLGPEMDRLGVRVFLGTQERPHDAQIETVLQDPAAGPWVAGVGFQWAGKGAIAAVHHAHPDLALYQTEQECGDGRNDWRFVRHTWGLMRHFFTHGAQAYTYWNLALTEGGVSRWGWAQNSLVVVDPETRTFRYTHEYFLMRHLGHFLQPGAQRLATMSWTGHENLLAFRNPDGGVVLVMQNDLGEPLPVQIVVGDDVITPTLPADSFATLVIPPA
>NZ_CP040750.1|WP_138945812.1|2000463_2001180_-|NUDIX-domain-containing-protein
MADSTTVREPQPGADLPDARGRTGLHRTGLDLTGNPRVQVTDVELVAAAWHVLRRTTLRVQDRSGAWSTQQRETYDRGNGATILLYHGDSRKVLLTRQFRYPAYVNGHPTGELIETAAGLLDDDDPETAVAREAREETGFAVEAVQHVFDAFMSPGSVTERLHFYAAEYDPAARLGDWGGLAEEGEEIELLELDIDDAIARIGDDIIDAKTIMLLQWARLSGPFATAPTPVPPAPPAR
>NZ_CP040750.1|WP_138945811.1|1999026_2000355_+|M20/M25/M40-family-metallo-hydrolase
MSVGERVSDPVGLSEVVSITRDLIRIDTSNYGGGRAVGESRAADLVERLLGEVGIVCERFEAEPGRTNLVARWPGRDRTLPGLLLHGHLDVVPVDAAAWTVDPFGGEIADGMLWGRGAVDMKNMVAMIVASVRRMVTAGEQPERDVVLAFFADEEAGCVLGSQWMVEHHPEQFAGVRDAISEGGGYSVTLGDRADTRAYLLNTGEKGVLWLRLTAHGAAGHASLASQDSAIVKLAAAVGRIGALDWPVSFTETTTHLFQRLRELTGASSELSPFELAALVGPSASRLRAGLQNVANVTMISGGYKENVIPESATATVDARFLPGQRDEVIARIREAAGEGVDVEVQLELIAMESPNDGELVSVIEAVIERHDPGATVLPHLIPGGTDAKALSRLGITGYGFIPLRLPADFDFPGMFHGVDERVPLDALDFGCAVLTDVIRSA
>NZ_CP040750.1|WP_138945810.1|1998229_1999030_+|carbon-nitrogen-hydrolase-family-protein
MRIASGQFSAGTDIDENLASVVALLGEAAAGGAELLVLPEMSSYATSEPPSALAAIAQPLDGPFITGVAAAAAARSLPTVVGTIEENPGGLPYNTLVAIDAEGDITATYRKVHLYDAFGYAESDGISAGELTEPFVLELGDLRIGAFTCYDLRFPESARRLIDAGANVILLPAMWIVGPGKEDAWTTLVRARAIENTAYVVSANQTGPLATGNSIIVDPAGVVIAAAGEAPGVVFAELDPARLDAVRARVPSLANRRFTVVPRTAE
>NZ_CP040750.1|WP_138945809.1|1997205_1998171_+|EamA-family-transporter
MSTAAPNTRVTALVAPGSRRVLGAYLGAALIWGASFLFMKTGLTGLAPAQVALSRVVLGALTLCIIMLVTRRRWPRERRLWAHLAVVSVFLCVAPFLLFSWAGQFLPSGLSSILNATTPIMTLAVGAVFLPKERLNRLQVFGIFVGALGVAIVVGPWRVLADPAILESIPAQLACLGATLCYGIAFVYLRKFVLGTHSYDAVVISAVEISLAAVIMLVLSPFIAMQPVSLDAPVVLSMLALGALGTGVAYIWMTTIVDSWGPTAASTVTYLTPLVGVVLGILVLGEILHWNEPVGGVIVVLGILVSQGRLRLRRRTPPLSA
>NZ_CP040750.1|WP_079000486.1|2007359_2008229_-|oxidoreductase
MTDTTTRPATAAGTFSLGGDLTVNRLGYGTMQLTGEGVWGEPDDRDGAIRLIKRAAELGVNFFDSADAYGPDVTDTLLREALHPYDDIVIATKVGQTRQGPGEWTPTGVPAYLRQQVELGLRRLAVDRIDLLQLHRIDPTVPFEDQIGELRKLQDEGKIRHIGLSQVSVAEVEAAQQIAPIASVQNLYNLTDRSSEDLLDWSTEHGVAFIPWFPLATGALSKEDGPLTQLAERHDATPSQLALAWLLKRSPVMLPIPGTSSIEHLEDNLQGATIELTDDEFEELSAVSE
>NZ_CP040750.1|WP_138945818.1|2008337_2009228_-|LysR-family-transcriptional-regulator
MLDVRRLRLLRELKIRGTIAEVAAALNFSPSSVSQQLSVLEQETGVELLRKVGRRVQLTPQAEILVGHTDALLDTLERAEADLGASLTTVSGTIRVAVFQSAALALMPAALSAMRRDHPDVRVEMVQHEPETALAETWARDFDVVVAEQYPAHAAPRHPGLDRRQLATDPIRLACPPVANEIHPVLRIEDAADLPWVMEPRGAASRHFAEQLCRRAGFEPDVRYQTADLQAQIRLIESGNAVALIPDLQWAGEPASCRLVDLPDLPRRTIFTSAREAGVTRPAIVAFRAALEDAAA
>NZ_CP040750.1|WP_138945819.1|2009317_2012791_+|aldehyde-dehydrogenase-family-protein
MTDTLASTQQLDRDALATEAIALVRRWLRTASTIPADASAQQLAGVLKDPTGLEFTVGFVDGVVRPEDLRVAARTLQTIAPKVPAFLPWYLKAAVRCGGAFAPILPGVVIPISRKVLRNMVGHLVVDATDKKLGPAIAKIKTPGTRLNVNLLGEAVLGTGEAARRLEGTHKLLARPDVDYVSIKVSSTVSPHSVWAFDEAVEHVVTSLTPLFERAATASPKKFINLDMEEYKDLDLTIAVFTKLLDLPQFRDLEAGIVLQAYLPDALSAMIRLQEWSAGRRAAGGAGIKVRIVKGANLPMEQVESSLHDWPLATWSTKQDSDTNYKRVVEYALHPDRIDNVRIGVAGHNLFDIAFAWLLAKQRGVERGVEFEMLLGMAQGQAEAVKRDVGELLLYTPVVHPQEFDVAIAYLIRRLEEGASQDNFMSAVFELSENETLFAREEQRFLASLAELDATVPAPNRRQDRTKPAEASPVDAFENTPDTDPSLPANRVWGRDILTRVTESRLGNDTVAASILDSVEALDAVIDGATAAGASWGSLSGAERAVILHRAGDVLEQRRADLMEVMASETGKTLDQSDPEVSEAIDFAHYYAERARELDHVDGATFTPAKLTVVTPPWNFPVAIPAGSTLAALAAGSPVIIKPARQARRSGAVMIEALWEAGVPREVLRFAQLADNSLGERLIAHPAVERVILTGGYETAELFRSFRPELPLLAETSGKNAIIVTPSADLDLAVKDVVASAFGHAGQKCSAASLVILVGSVASSRRFRHQLVDAVTSLKVGYPVDPTTQMGPIIEPAKGKLLGGLTTLGSGESWLVEPKQLDDSGKLWSPGVRAGVARGSEYHLTEYFGPILGIMTAETLEEAIAIQNEIDYGLTAGLHSLNPAELRLWLDGIQAGNLYVNRGITGAIVQRQPFGGWKKSAVGAGTKAGGPNYLIGLGSWSSAESTAERTVGRSAERRGPKPAVASLLRAADAVLTADEFAFLRRSVASDAAAWADEFGVATDVSKLTAERNVFRYVPREVHVRLVDGGSVAELLRVVAAGATAGATVHVSSAVALPPKLVPAVEAIAGGITVESEDRWYVTAASLVGTKSGARVRIIGGTTEGVAHATSGSPDVAIYAGDVTEAGRIELLPFLQEQAVSITAHRFGTPNHLSDDLI
>NZ_CP040750.1|WP_138945820.1|2013046_2013622_+|hypothetical-protein
MKVRAYLATLAIAALLSGGSAVLTPSDASAVPLISEATSDGGFAIRGTDDAVRSIIPDGKNTSSVSGMSAKVSMEPTDRIVLSADARLLVLQDQDGGVLLSSANPTLEQGTETVPAKFVLEDGHLIVTPIEHTPNLARAACASSFWGNLIFNIGIAGVCAMLDIATAGPGGVACTMAVIGANLGIDWDRPC
>NZ_CP040750.1|WP_138945821.1|2013631_2013895_+|hypothetical-protein
MSHSRKLRSTRIDWKNMRQFGWFLGLLWGLTVLGTFVGLLVQALLGARTWSDVPSDMVPVLLGTSLGYGLLWLGSNIATRRRKHPPE
>NZ_CP040750.1|WP_138947258.1|2014090_2015095_-|aldo/keto-reductase
MPYEAAETRYDDMTYRRVGRSGLRLPALSLGLWHNFGEGRSIEVQRAIVRRAFDLGITHFDLANNYGPPAGSAETAFGRIFAEDLAAHRDEIVITSKAGYYMWQGPYGEWGSRKTMLSSLDQSLGRIGVEYVDVFYSHRPDPETPIEETMGALATAVKQGKALYAGISNYSPEQTIAAAAALREHGVPLLVHQPRYSMFSREVEDGLLDTLDDLGLGAVVFSPLAQGMLTDRYLGGTVPSDSRAATSHFLNEESITDTYLQRARGLQAIAEERGQTLAQLALSWVLRRDTVTSAIIGASSVEQLEGNYAAIHRLDFDDAELARIDEFAVHGTLR
>NZ_CP040750.1|WP_138945822.1|2015192_2015660_+|NUDIX-domain-containing-protein
MSSTSLPSAEGPAPHPRSGCGVAIVREGRILLLERLREPEAGSWGIPGGKVDWMERLEDAVRREAMEETGLDLGSIELLCVVDHFEEALHQHWISPVYLAADTVGEPELREPEKHGGLRWFPLDALPERVTVSTVAAVEAIARPRGSRRPDGADS
>NZ_CP040750.1|WP_138945823.1|2015670_2016771_+|hypothetical-protein
MTDHPSSDARNDFITFDALRAEAVEQPVRRGAGAWGFFGTVAIVIGALLIPVALVSTWADTMLRDTDAFVDTLAPLATDPAVQAFVGEQALAVLESQVDLDAAAAAPADLAATLALPPAISEVLGAIGGDTADALREVLRRNVAEFAASPAFATAWTEALRVTHEQLVAGVSGSRGAVIDVSAEQGLGVQLGPIVSATRTWLVDAGFGFAAVIPDVDRVVDVVPAAQVAPVLDGIRVIETAAGWSPWLAIGLLVLGVILLWLGRRNPSRTVAGAAIGMLLAAGLTLILLGAARLALVFAVSVAIPGGVGDAAASLLLGPPTDAAWSVLWVSLVVAVLAFVSAALRLPERIAQGVRAARRPLSGTNA
>NZ_CP040750.1|WP_168223361.1|2016767_2017925_-|acyltransferase
MPSPENRATGHRRRNRRTAPRVDHTAFAGARAIAAWWVVFSHSADWLFSVLPELSWLAPMAHTGLAVDVFFVLSGYTIARAYLDRRWNWPAYGRYLRNRVARLYPAHVAMLLAFVMLCVGGAVVGIAADDGAFPPIGLIAELTLTRAWFGDALWWNPPAWSLSAQFLAFILFPVFALAFRGRMRGPGPMIALSVGLVSTTTIAAAVAPSAMNGMAPPALRVLCCFALGICVAEWTAALPVTRRAAWVAAGGAVGLVVAAIALEPGAPRAWAAITFAGIIVGGLAVASPRSTAVLRSRPARFLGRLSFSTYLVHVFVLILLAKAITPSAVDGMPLLLRAPIILAWFGSILAASWLLHTLVEVPWHRRLAAPRTSRAIHADGSATDA
>NZ_CP040750.1|WP_138945825.1|2018014_2019772_+|hypothetical-protein
MDRTSRRGGTVRWRTTGAEPEPVPEPEPTAAEPEPDREAPSSPSDPAPSAPTGSADPQAAPSVELVLEGPGIDPTGASVSTTAVLAWFAAVPSGSTVIVRGGDVIAVDATIRIDRRVHLRGRGELRFVGGVEAAPALKLIVSGSSVTGVRVSYAGPPASSTGERNTGISIWASDVLIDGVTVDGFQNGIAVQPSGEFEGVVISACHVLNVVGSGGGRGSTSSAGEDRGDGITVWGARSAVVGNIVSAAPGIDARVGIHAENLPDFAVDPGSWADSMVTIEGNVVTGPFRRSIAVEGMAHAVVTGNTVSDATWWGLAVIDTRSVTLVANTVRWTRTADDDQGSAWGPKRCPVMIYRDAQGTVVSGNVIEIRGVAAAGIMAQAATPPRGSTTVIGAVDALITDNVVRIAGGTCPIGIALDRTRQPVVSGNRVAITLASGSVGGVVSYLAEDAVVSDNSITGAATSNGFGVLHQGAGSIVVIGNRIDRIRVAVAVSNCTGGATIIGNTARECEYGLDTFGTTGHSVVQGNRWETSNTAHANAQPNTSYLSTRHMGLARPYGGRSGDILVGNGRLWVNDQGTWRSTTLS

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Crispr_ID: NZ_CP040750_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_12

2168182-2168309

Orphan

Consensus_repeat	Method
GCTCCTCGCCGAGCGGAGCTACCGCTCGGTCTGGGAGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_12

>merge|NZ_CP040750|12|2168182-2168309|CRISPRCasFinder
GCTCCTCGCCGAGCGGAGCTACCGCTCGGTCTGGGAGGTGTGAGACCTGGTCTCGCCAGGACGGTGGCCGTGCACGCGGAGCTATCGGGGCTCCTCGCCGAGCGGAGCTACCGCTCGGTGTGGGAGGT

>NZ_CP040750|12|12|2168182-2168309|CRISPRCasFinder
GCTCCTCGCCGAGCGGAGCTACCGCTCGGTCTGGGAGGT	GTGAGACCTGGTCTCGCCAGGACGGTGGCCGTGCACGCGGAGCTATCGGG
GCTCCTCGCCGAGCGGAGCTACCGCTCGGTGTGGGAGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_124768057.1\|2162121_2162325_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138947266.1\|2166506_2167298_-\|GrpB-family-protein	unknown	unknown	gnl\|CDD\|377252
NZ_CP040750.1\|WP_138945907.1\|2158624_2159977_-\|cytosine-permease	unknown	unknown	gnl\|CDD\|271377
NZ_CP040750.1\|WP_138945915.1\|2168323_2169439_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176211
NZ_CP040750.1\|WP_138945918.1\|2171365_2171671_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_085511274.1\|2164915_2165122_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945919.1\|2171682_2172828_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_168223368.1\|2173512_2173797_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240291
NZ_CP040750.1\|WP_138945908.1\|2160271_2161000_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP040750.1\|WP_138945911.1\|2163579_2164488_-\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP040750.1\|WP_168223367.1\|2169539_2170106_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP040750.1\|WP_138945917.1\|2170563_2171247_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197666
NZ_CP040750.1\|WP_085511262.1\|2176445_2177363_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP040750.1\|WP_138945909.1\|2161062_2161350_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_085511268.1\|2170189_2170588_+\|glyoxalase	unknown	unknown	gnl\|CDD\|319901
NZ_CP040750.1\|WP_138945912.1\|2164557_2164770_-\|HVA1-family-protein	unknown	unknown	gnl\|CDD\|378576
NZ_CP040750.1\|WP_138945910.1\|2161403_2161961_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP040750.1\|WP_138945913.1\|2165172_2166447_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NZ_CP040750.1\|WP_085511264.1\|2173868_2174915_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP040750.1\|WP_138945920.1\|2172900_2173485_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138947266.1\|2166506_2167298_-\|GrpB-family-protein	gnl\|CDD\|377252	pfam04229, GrpB, GrpB protein. This family has been suggested to belong to the nucleotidyltransferase superfamily. It occurs at the C-terminus of dephospho-CoA kinase (CoaE) in a number of cases, where it plays a role in the proper folding of the enzyme.	6.21831e-62
NZ_CP040750.1\|WP_138945907.1\|2158624_2159977_-\|cytosine-permease	gnl\|CDD\|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	3.34561e-78
NZ_CP040750.1\|WP_138945915.1\|2168323_2169439_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176211	cd08249, enoyl_reductase_like, enoyl_reductase_like. Member identified as possible enoyl reductase of the MDR family. 2-enoyl thioester reductase (ETR) catalyzes the NADPH-dependent dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the alcohol dehydrogenases in this family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. Candida tropicalis enoyl thioester reductase (Etr1p) catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis. Etr1p forms homodimers with each subunit containing a nucleotide-binding Rossmann fold domain and a catalytic domain.	4.17453e-109
NZ_CP040750.1\|WP_085511264.1\|2173868_2174915_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.02292e-93
NZ_CP040750.1\|WP_085511268.1\|2170189_2170588_+\|glyoxalase	gnl\|CDD\|319901	cd07235, MRD, Mitomycin C resistance protein (MRD). Mitomycin C (MC) is a naturally occurring antibiotic, and antitumor agent used in the treatment of cancer. Its antitumor activity is exerted primarily through monofunctional and bifunctional alkylation of DNA. MRD binds to MC and functions as a component of the MC exporting system. MC is bound to MRD by a stacking interaction between a His and a Trp. MRD adopts a structural fold similar to bleomycin resistance protein, glyoxalase I, and extradiol dioxygenases; and it has binding sites at an identical location to binding sites in these evolutionarily related enzymes.	1.36027e-49
NZ_CP040750.1\|WP_168223368.1\|2173512_2173797_-\|hypothetical-protein	gnl\|CDD\|240291	PTZ00146, PTZ00146, fibrillarin; Provisional.	0.00239342
NZ_CP040750.1\|WP_138945913.1\|2165172_2166447_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	5.38552e-26
NZ_CP040750.1\|WP_138945911.1\|2163579_2164488_-\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.57646e-26
NZ_CP040750.1\|WP_085511262.1\|2176445_2177363_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.97794e-70
NZ_CP040750.1\|WP_138945917.1\|2170563_2171247_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.8107e-15
NZ_CP040750.1\|WP_168223367.1\|2169539_2170106_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.96831e-11
NZ_CP040750.1\|WP_138945912.1\|2164557_2164770_-\|HVA1-family-protein	gnl\|CDD\|378576	pfam11160, DUF2945, Protein of unknown function (DUF2945). This family of proteins has no known function.	2.08107e-17
NZ_CP040750.1\|WP_138945910.1\|2161403_2161961_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.01361e-19
NZ_CP040750.1\|WP_138945908.1\|2160271_2161000_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	6.51285e-09

>NZ_CP040750.1|WP_138947266.1|2166506_2167298_-|GrpB-family-protein
MGAHALGAAAYAAKAAELQQAGAGAAEIAWQLDHLSDPIRSALSLLPALGTDPSGPLGSGLLASGALGANIRALQDGLRRRPRHQDVTALELVGGPEPVRVELHDADPQWPERYLEHRQRILDALGASAVAIEHIGSTSVPGLAAKPIVDIVVAVEDITAEEEYLDPLLAAGYVLRVREPRHRMVRTPERDVHVHLYEQGAPEIDEYLLLRDHLRSDADDRALYERTKRELLGRSWDDMNDYADAKTEVILAIKARARAARSR
>NZ_CP040750.1|WP_138945913.1|2165172_2166447_+|threonine/serine-exporter-family-protein
MSDDTATEEHRRTAAHAYSALGCLLLDAGTSVTDVRDSLERATVASGDEGLAFSVLPQLIIVNDVRTGAVLAAGNTHGELSFRGAARANRLMRELELGHWPVGDLPARIQSIRETPRPHASMHWVVGNLLLAGGLALLFRCPWWAIVASMLVGAFVGLVITLLARWRGAVAIAPFVTAFVSTTLVGTLASAMDLGPVPLFAVCAPIAILVPGALITNALLELTATDIVTGSARLMYGLIVLAFMAAGISAGALLTGLSIDPDSTALVGQVVRGSSDLVGWESVPPLWFTWIGVVMLAAGIGIAFGSGRSLTLLTICVMALTYAGIVLFAPLVGNAVATGLTAGLVFVVARIVERYSAAVPSNVTFQPALLMLVPGTVGLVSLATLEGSAVTAALTVFISLCVGVKTAAVLTGVVIPPVRATVRP
>NZ_CP040750.1|WP_085511274.1|2164915_2165122_+|hypothetical-protein
MASFTPGRPRLALGIGIVAVVLGVALIPVAIANAHGEYGFHFWWIVIVPILAGLYFGVAGAVGLRNRR
>NZ_CP040750.1|WP_138945912.1|2164557_2164770_-|HVA1-family-protein
MADVRVGDRVSWGTSQGRTQGKVVERKTADFQFDGQHFTASKDEPAFIVESEKTGAKAAHKSSALRVLKS
>NZ_CP040750.1|WP_138945911.1|2163579_2164488_-|cation-diffusion-facilitator-family-transporter
MTVVIAFLANIVVAIAKSIVAALTGSASMLAEAAHSWADAGNEIFLLIADKRADKQRDAAHPLGYGRDAYIFSLFAAFGIFTVGAVVSIQHGIQSLTAPEAMENYALSYLVLGVAFLLEGFSFTQSILEGRRTAKKYGRGFFDYIVNGSNTTLRSVFFEDSAALLGLIIAGAGIGLHQVTGDPVWDAIGSIAIGVLLGGVALLLINRNRRYLLGASPSPAYRAQTITALLSHPEIERVTALYLEFSGPERLFLVASVDLVGDDRENDVARQLRRLEGDLEQDDLIGKAVLTLSVSDEPSITV
>NZ_CP040750.1|WP_124768057.1|2162121_2162325_+|hypothetical-protein
MSQVERERPLLRKGSEASFVRWAFDGRSWCADLVSGQYRGATKTGWLLQTENEQRELSNQEWAPCMA
>NZ_CP040750.1|WP_138945910.1|2161403_2161961_+|GNAT-family-N-acetyltransferase
MTDATPPTLTERLTLARPTERDLPELHELHADPAVWTHLPSARHTTLDETRALIERYQAGWEANGLDVWVARDTATGALVGIGGPSLRGGLAWNLYYRLAPAAWGRGYAQELIAAARAAASASAPDLPVVAFLLEHNEGSRRAAERAGLEVVWRGADAGNPDPDAVRLVFADRALSDEALRVFVG
>NZ_CP040750.1|WP_138945909.1|2161062_2161350_-|hypothetical-protein
MAAKNEPISARACAILSIAIAAFSIYLVAATARDGGSWTFSVLACFVPLLFAAQGIRMSRQPGARWPTFSLIGSIVGAALGLVSFAAFAWLLVRS
>NZ_CP040750.1|WP_138945908.1|2160271_2161000_-|alpha/beta-fold-hydrolase
MRLHVEERGHGPVRIALIHGFLADGAAWTDVVAASDPERYTFLLVDLRGHGSSPRADRTRGERYDIASLAADLVDTLPTGLDAIVGHSLGGRLLIDIVGPLRPAHAIYLDPGFGLKLPGRGFGARLFWAIPGLPRLLAWLYDRTDPATGPANVALAEAAHAAWDRSMVAEVLQDVAANPVTPSAPTVPSTLVLSDDAKLVLPRADVERYERFGWTVTRFPGIRHDMAALDGARTFEVIQASL
>NZ_CP040750.1|WP_138945907.1|2158624_2159977_-|cytosine-permease
MARMAHADDFALSRVRPDAQKPWFGIAVQRFGQVSALSQFLLGATLGYSMTFGEAFLALLLGSIILEVIMCIVGIIGQKEGLNTALLARWTGFGEVGASLVGLAIGISLIGWFGIQSAISAESLDALLPGFMPVWAWSLIFGLAVTAIVAYGFKGMQWLANITVPLFLILVGWSIISELTQHDFMELVTGPAPGPTMSVWAGTGIVAGGLIVGAIITADMTRFNRSRADVIKQTVVGVSLGEFVIGLSGVLLAHAAASGNVVAIVTSSVGLIGLIIVITGTLKINDWNLYSSTLGLVNFISTAFGKNLNRVTTTIVLGVVGSILAAVGILGQFSGFLIILGVAFPPIAGIMVAEYFIVKRWRGELDETRASGRLPTTAPRIVPATIIIWAVSAITGYFVTWGIPAVLSLILSMVLYIAAGKLGLVRGVGVAHTSQIEADVTTDTPATASS
>NZ_CP040750.1|WP_138945915.1|2168323_2169439_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MPTNTAAWLPAPRADLVVGPAAMHEPGPGELLIRNRAVAVNPLDDVKQRTGNLMYRWLPSPAVLGEDVAGEVVAVGPDVRRFAVGDRVVAYAVGMERGRRHDAEGGFQQFTVVRADLAAPIPDGLRDEDAVVLPLGISTAATALFQRDHLALPHPSEHPVPTGTTVVVWGGATSVGSNAIQLAVASGHRVATTASPHNHDRMRELGADLVFDYRSPTVVADLVSALRGSSVVGVLAVGTGSAEPAVAAAAATGARRVALASPSVSFGSLPRRAGPSLTFVRTMTRLVAANVALQVRARRAGISARYVWGSSLMTNEVGPMLWEDYLPGALAGGRHVCAPAPEVVGEGLEAIQPALDRLHGGVSARKLVVRL
>NZ_CP040750.1|WP_168223367.1|2169539_2170106_+|TetR-family-transcriptional-regulator
MARWAPDAALRLESAAMALFAERGFTATTVPEIAEAAGLTTRTFFRHFADKRDVLFLRERELPTVVGGLVAVAPPGLDPLALVMSGLETVAAGELQRWRDDIAARRAVVRSEPQLRERERLKSAVLTDAMRDALMESGVTSADAALAASIGSALFDASLEQWLAGPDDVLLVDVLRAMRARLGDLAGR
>NZ_CP040750.1|WP_085511268.1|2170189_2170588_+|glyoxalase
MTLRLGFIGIVTNDMAASLAFYRALGVPIEPGQDDAPHVDALLDGGVALAWDTVETIRGFDPTFVPASGGHRIALAFDQGSPAAVDATFATLVDAGYAGHVEPWDAVWGQRYATLLDPDGNSVDLYAALAAN
>NZ_CP040750.1|WP_138945917.1|2170563_2171247_-|helix-turn-helix-domain-containing-protein
MYSERVLLSGDALWRSEDSAGGAAVPADGCVDLILRDGRVEVAGPSTRWLATGPDGAAGSFGFRMQPGRARLLLGLDLAAIADQLVLLGDVTDRRTAARLREAMIPLEAGPSPIGTLATFAAQLAEASRWSDAVRRAASEATPARDVAATLSGSERSFRRRMLATFGYGYATLVRLDRAHHARSMLRSGSSIADVAASAGYADQPHLSREFRRLVGSSPAQFAASAA
>NZ_CP040750.1|WP_138945918.1|2171365_2171671_-|hypothetical-protein
MNSTSASSQAWLALSWSTSALSAAFLGAGVVSISTYASFLDFPQDDPGWISHHDWLASTGTAALIIGAALAVCSVVAFILWQVGLPQQPVGQGGRSSAEHR
>NZ_CP040750.1|WP_138945919.1|2171682_2172828_-|hypothetical-protein
MGESRGALARRNARRAIAIGLGAVTAAVLLTGCGSSAGADAARASIVEAVEDLPDVADVSGTVEASNGGGLETYYNARITVEMADGAPPESYTDVATAAARSTDGKESGEVIVEDAAGGSVTFDTGAPPETIDATVTAWRDWAADGDPAEVDAVRVELVEVELIALSARENRPASSELKVLFVYADPLTPTDAARLVGGFQAELPMPLASAEISLVLSNPDPGSAGVHVLAWGLPVPASVLETIAVIEGTTAVLAPLGGSVAGIDWYAEQLDHGLDRPDELIVSVAFPEDAPLGGVPLAELQASPQWAAYQQVTTLANTSATAISFSMSADNPRIAGFTAQPCGSADDELDPPRDPSEADQAIAAWWLAQAPACPGVGRHE
>NZ_CP040750.1|WP_138945920.1|2172900_2173485_+|hypothetical-protein
MPNREPSSTNPYRMSRRRISTLSGALIGSLVLLVVVALVGAAIGGDDAESWVAIVLYVAFGLPLAVGAVLGGLAISRWGWVAGTVFGLGWLTILVVVFDNGFGLFYDGEAVGPVVFDNAIWQLIGVAGLVVGGALFFVAGWLSQVPMWIGGPAGGVDVSRRKRSGEGNAVVPPAKRKPRQKQQPKRRSKQQRRR
>NZ_CP040750.1|WP_168223368.1|2173512_2173797_-|hypothetical-protein
MDSSTVIMIAVLAVVAVIVVTITVQARRRAGGSKHRGGTTSDSGMPFIVDSDGHHGGGHHGGGHHGGSDSGGWDGGGGGDSGGGGDGGGGGGGD
>NZ_CP040750.1|WP_085511264.1|2173868_2174915_-|LacI-family-transcriptional-regulator
MPDSDVGASVTGTPGRAATLGDVARIAGVSMATASKAINGRSEVAPKTRQRVLDAAKEVAFTPNELARSLINGRTGTVGLLTSDLEGRFVIPILMGAEDAFGAGQVNVFLCDARGDAIREQHHLNALLTRRVDGIIVVGRTTDPRPSLGHKLPVPVVYAYAPSDDPTDVSITPDNRDGGRLAVEHLIACGRSRIAMITGEPQYAAARDRVTGVQNALAAAGLDLVGTPMFSEWTEHWGRDAAAMLLAQHPEIDGIVAGSDQIARGVLDTVRDLGRDVPSDVAVVSFDNWEILATNSRPELSSIDANLQQLGRLAATRIFEAIEGTDVAPGVEYLPGRLVLRGSTIPRR
>NZ_CP040750.1|WP_085511262.1|2176445_2177363_+|sugar-ABC-transporter-permease
MSTTLARRGPTDSVGARKRRAVHARTGWLFALPTAVFVILLFLVPLGLVFQMAASDWPLLGGNQGVNFPENFPKAIDNRFFLDSVVFTLKYTAIATVLLIGLGLGLALLVQESSRWKGFLRTAFLIPSALGLASASLLFYVLYSPIAGPFADLTKAMGFTFLGTPDAALWSTVFLIVWRFAGFYMLLMLVGLQGIPEEVYEAARIDGASRWQTFRDITVPLLKPTLALTTVMCVTGSLLAFEQFYILTKGGPDNSTITIVQLIYNVAFQGPNNLGVAGALSVIVLAALIVINIVQIRAFSKKVED

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Crispr_ID: NZ_CP040750_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_13

2257464-2257590

Orphan

Consensus_repeat	Method
CGGCGGGCGTCGAGGGCCCGCCGAGCGTGAGTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_13

>merge|NZ_CP040750|13|2257464-2257590|CRISPRCasFinder
CGGCGGGCGTCGAGGGCCCGCCGAGCGTGAGTCCCGTCGATGGTGCCGACGGTGCCGACGGCGCTGCCGATGCCACCGGGGCAGGGGGTGCGGCGGCGGGCGTCGACGGCCCGCCGAGCGTGAGTCC

>NZ_CP040750|13|13|2257464-2257590|CRISPRCasFinder
CGGCGGGCGTCGAGGGCCCGCCGAGCGTGAGTCC	CGTCGATGGTGCCGACGGTGCCGACGGCGCTGCCGATGCCACCGGGGCAGGGGGTGCGG
CGGCGGGCGTCGACGGCCCGCCGAGCGTGAGTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138945988.1\|2263841_2265362_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227621
NZ_CP040750.1\|WP_138945977.1\|2250157_2250835_+\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|133000
NZ_CP040750.1\|WP_079704610.1\|2258870_2260082_-\|toxic-anion-resistance-protein	unknown	unknown	gnl\|CDD\|377557
NZ_CP040750.1\|WP_138945975.1\|2246867_2249159_-\|FdhF/YdeP-family-oxidoreductase	unknown	unknown	gnl\|CDD\|273765
NZ_CP040750.1\|WP_138945980.1\|2251702_2252338_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238452
NZ_CP040750.1\|WP_085511191.1\|2253159_2254329_-\|cysteine-protease-StiP-family-protein	unknown	unknown	gnl\|CDD\|378594
NZ_CP040750.1\|WP_138945978.1\|2250831_2251104_+\|molybdopterin-guanine-dinucleotide-biosynthesis-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138945976.1\|2249155_2250064_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl\|CDD\|234823
NZ_CP040750.1\|WP_138945983.1\|2255701_2256895_-\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	unknown	unknown	gnl\|CDD\|379744
NZ_CP040750.1\|WP_079704611.1\|2260134_2260713_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NZ_CP040750.1\|WP_064295863.1\|2257749_2258301_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NZ_CP040750.1\|WP_138945987.1\|2263339_2263837_-\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|377229
NZ_CP040750.1\|WP_079704613.1\|2261491_2262715_-\|TerC-family-protein	unknown	unknown	gnl\|CDD\|274743
NZ_CP040750.1\|WP_138945979.1\|2251100_2251739_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238452
NZ_CP040750.1\|WP_138945989.1\|2265568_2266222_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_168223369.1\|2254310_2255705_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379740
NZ_CP040750.1\|WP_086472760.1\|2262837_2263329_+\|winged-helix-DNA-binding-protein	unknown	unknown	gnl\|CDD\|197670
NZ_CP040750.1\|WP_138945985.1\|2260771_2261362_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NZ_CP040750.1\|WP_138945981.1\|2252350_2253163_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319822
NZ_CP040750.1\|WP_079704609.1\|2258300_2258816_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138945988.1\|2263841_2265362_-\|hypothetical-protein	gnl\|CDD\|227621	COG5305, COG5305, Predicted membrane protein [Function unknown].	7.6084e-24
NZ_CP040750.1\|WP_138945977.1\|2250157_2250835_+\|NTP-transferase-domain-containing-protein	gnl\|CDD\|133000	cd02503, MobA, MobA catalyzes the formation of molybdopterin guanine dinucleotide. The prokaryotic enzyme molybdopterin-guanine dinucleotide biosynthesis protein A (MobA). All mononuclear molybdoenzymes bind molybdenum in complex with an organic cofactor termed molybdopterin (MPT). In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). This GMP attachment step is catalyzed by MobA, by linking a guanosine 5'-phosphate to MPT forming molybdopterin guanine dinucleotide. This reaction requires GTP, MgCl2, and the MPT form of the cofactor. It is a reaction unique to prokaryotes, and therefore may represent a potential drug target.	2.37749e-24
NZ_CP040750.1\|WP_079704610.1\|2258870_2260082_-\|toxic-anion-resistance-protein	gnl\|CDD\|377557	pfam05816, TelA, Toxic anion resistance protein (TelA). This family consists of several prokaryotic TelA like proteins. TelA and KlA are associated with tellurite resistance and plasmid fertility inhibition.	4.5237e-93
NZ_CP040750.1\|WP_138945975.1\|2246867_2249159_-\|FdhF/YdeP-family-oxidoreductase	gnl\|CDD\|273765	TIGR01701, Hypothetical_protein_Rv2900c/MT2968/Mb2924c., oxidoreductase alpha (molybdopterin) subunit. This model represents a well-defined clade of oxidoreductase alpha subunits most closely related to a group of formate dehydrogenases including the E. coli FdhH protein (TIGR01591). These alpha subunits contain a molybdopterin cofactor and generally associate with two other subunits which contain iron-sulfur clusters and cytochromes. The particular subunits with which this enzyme interacts and the substrate which is reduced is unknown at this time. In Ralstonia, the gene is associated with the cbb operon, but is not essential for CO2 fixation.	0
NZ_CP040750.1\|WP_138945980.1\|2251702_2252338_+\|hypothetical-protein	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	2.01832e-34
NZ_CP040750.1\|WP_085511191.1\|2253159_2254329_-\|cysteine-protease-StiP-family-protein	gnl\|CDD\|378594	pfam11202, PRTase_1, Phosphoribosyl transferase (PRTase). This PRTase family is fused to a C-terminal RNA binding Pelota domain, pfam01248. These genes are found in the biosynthetic operon associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	4.67997e-142
NZ_CP040750.1\|WP_138945976.1\|2249155_2250064_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl\|CDD\|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	2.00636e-113
NZ_CP040750.1\|WP_138945983.1\|2255701_2256895_-\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	gnl\|CDD\|379744	pfam15617, C-C_Bond_Lyase, C-C_Bond_Lyase of the TIM-Barrel fold. This family of TIM-Barrel fold C-C bond lyase is related to citrate-lyase. These genes are found in the biosynthetic operon, with other enzymatic domains, associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	1.92909e-150
NZ_CP040750.1\|WP_079704611.1\|2260134_2260713_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	2.60097e-107
NZ_CP040750.1\|WP_064295863.1\|2257749_2258301_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	1.17588e-58
NZ_CP040750.1\|WP_138945987.1\|2263339_2263837_-\|GtrA-family-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	6.4213e-24
NZ_CP040750.1\|WP_079704613.1\|2261491_2262715_-\|TerC-family-protein	gnl\|CDD\|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	3.09458e-139
NZ_CP040750.1\|WP_138945979.1\|2251100_2251739_+\|hypothetical-protein	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	2.53143e-43
NZ_CP040750.1\|WP_168223369.1\|2254310_2255705_-\|hypothetical-protein	gnl\|CDD\|379740	pfam15609, PRTase_2, Phosphoribosyl transferase. This PRTase family, and C-terminal TRSP domain, are related to OPRTases, and are predicted to use Orotate as substrate. These genes are found in the biosynthetic operon associated with the Ter stress-response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	4.50585e-61
NZ_CP040750.1\|WP_086472760.1\|2262837_2263329_+\|winged-helix-DNA-binding-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.97665e-17
NZ_CP040750.1\|WP_138945985.1\|2260771_2261362_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	1.10531e-59
NZ_CP040750.1\|WP_138945981.1\|2252350_2253163_-\|HAD-family-hydrolase	gnl\|CDD\|319822	cd07520, HAD_like, uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.06502e-09

>NZ_CP040750.1|WP_138945983.1|2255701_2256895_-|HpcH/HpaI-aldolase/citrate-lyase-family-protein
MRHFSYVDDKRASRLFHKLPSPISIDSPPEHVAAALGATLYSPGTRPTLAKDVVKQAKHGCLSMVLCLEDSVPDDAVEFAETNVAEAMQQLAAKSSGSKRPVLPLLFIRVRTPEQLERVAGLLGPGLDLLSGFVIPKYENSDGVADRFFEALGRVQRDYGQDGSNGARRLRVMPILESPRMIHRETRDDTLSGIVDVTKAHREDVLAVRIGATDLSSAFSLRRSRDLTVYDVKLVSSVIADVVNVFGRPGDDFVITGTVWEHFHNAERLMRPQLRMTPFQDANEAQLRQKLLLKGLDGLIREIALDQANGLLGKTVIHPSHVPVVHAMSVVSHEEYVDALSVVGDVGGGANASPYRNKMNEMKPHQAWARKTLLRADAFGVAAEETTFVDLLETSMR
>NZ_CP040750.1|WP_168223369.1|2254310_2255705_-|hypothetical-protein
MTAWTGRFVSDAVGIGLRSDASRSLIPVEDLVGLALRDNPKRAQLLVSTVLAKHVPTVPGLALTAGELLGLLVRSALDDSDPETAPFDTVAQLLARRERPDAEGLAALTAVREHLAQLRDAAPAAGPELVTVGYAETATGLGHIVADALGSPYLHSTRHEADVPFTPFEEEHSHASDHRLYPSDPAWATVGGTTVLVDDELSTGRTVRNTITALHATTPQAHWVVAGLIDLRSDADRQRFDDLAHHLGTRITVVALGVGAVDLPEDVLARARAVIDAAPAASVAGSTAAGDVVVVDASDLPPVRSARFGAPGRLDGAVTAAIADRVLPELPDGEVVVLGSEEFIAVPLAVAAHLDRARGATRFSTTTRSPIAVIDRDDYAIASAVSFTSHDRTIDGFGPRFAYNLSRGGSRFAAVVLFPEPGADRELLLRPDGVVEALRTVTEHVIVVLLTESVPTPAEWNPAP
>NZ_CP040750.1|WP_085511191.1|2253159_2254329_-|cysteine-protease-StiP-family-protein
MEPRTVTIDAAALPEPLTGPDFGSYDASEVRWLLTDLGDTRLEADASEREAAIQSGRAHYAESLPIEYLPSPEYEELYRDALARSSRRLAVAVGVVTDLVLASRANRPVLVSLARAGTPIGILMRRWAKEVRGIDVPHYTMSIVRGVGVDGTALRYLAAHHDPEQIAFVDGWTGKGAIARELTAALELFAETDGIRFSDELAVLADPGHCVPVYGTRDDYLIPSACLNSTVSGLVSRTVYNRELLSDDQFHGAKFYRELSSHDVSGAFLDAVSSRFAEVVDDVAAGVEEASAADREPSWIGWEAVERIREQYDIPTVNLVKPGVGETTRVLLRRVPWKVLVSPDALDDVAHVLLLAEQRGVPVEVVPGLPYSCVGLINPLSDAAAGDAQ
>NZ_CP040750.1|WP_138945981.1|2252350_2253163_-|HAD-family-hydrolase
MSALVACDLDRTLIYSPKAFWLETPDPEAPSIIVSELWNGVPISFMTRESERLLIELRSHAVFMPVTTRTVAQYQRVQLPGGAPAYAITSNGGEILVDGVPDADWRDRVRAHLTDHTAPLDEALARFEELASPTWILKTNVADALFFYSIVERDAIPAGWLEQVEQECERLGWTVSLQGRKLYCVPRTLTKHDAVSEVARRLDGPLVLAAGDSLLDQSMLETADLAFRPAHGELDDEGFTIDTLTVTERRGILAGEELLRLMTAAAVRGR
>NZ_CP040750.1|WP_138945980.1|2251702_2252338_+|hypothetical-protein
MRDSFGPSLPGVIASLGGVVTSSVRVGDDASTTADALGLTSAVGAPACHQRDLIVTTGGTGDSRADHVRALLRDAGADFLVDGVDVRPGGPALLARLPDGRLFVGLPGNPLAALLSVLTLVHPVLAGLQGLELPALRPAVLASPVDGVRSGTVLRPYRSVHDPDSATPHAEPTPWHGAAMLRGLADADGVLVCPGSGAAAGGLVPSLDLPW
>NZ_CP040750.1|WP_138945979.1|2251100_2251739_+|hypothetical-protein
MTRSSWSDARSIAHAAGAAQRSDVVDTLALAEALGHVLAAPLVSPIAIPHYASSAMDGWAVAGNGPWTLLTGDDAERGRSVGLSDGVAVDVLTGGLIPAGADAVLQLEHGVVEQGSGSARLHLAPSAPSGEPRPGRHIRPAGTESPAGSTVLDAGTRLGPVHLAVAASAGFDRVSVMPLPRVRLVLTGDEVVTSGVPAPGSCATASVHHSRE
>NZ_CP040750.1|WP_138945978.1|2250831_2251104_+|molybdopterin-guanine-dinucleotide-biosynthesis-protein
MTDDLHAVLADWTERVSAELELGDVVVDIDAVLGLAGTAAHAVLRPAAPLTTYLVGIAVGKALASGADPVAAAEAATAAVERLVASDSTA
>NZ_CP040750.1|WP_138945977.1|2250157_2250835_+|NTP-transferase-domain-containing-protein
MSVDAIILAGGRSSRLGGVAKASLLRDGRTLLQLAIDAARVADGRVVVVGPEVEMTDPVRFVRERPVFGGPAAAIAAGLDALRDDVAAEGPAQVAVLACDMPDAAPALAAVLDAATAATGTDTDGWVAVDDSGREQSLLAVYRREALERRVAALRASQPSGDLAGVSVRQLLAGLVLRQVPIPAGGSADVDTWADATELGVVTAVESPAPTASTTPTADPEERLP
>NZ_CP040750.1|WP_138945976.1|2249155_2250064_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MTRITARRRVTRITVGQPARTREDVLAVEEPLEIRVGGRSLAITMRTPGHDVDLAIGFLVSEGVIARGDDVRTARYCAGATDEGVNTYNVLDVALSPGVPAPDPSLERNFFTTSSCGLCGKASIDAVRTSSRYTVADDDFRLDPALLVTFPDRLRAQQAVFERTGGLHAAGLFDARTGEMLVLREDVGRHNAVDKVVGWAAKEGLLPLRSMVLMVSGRASFELTQKASMAGIPMLAAVSAPSSLAAELATELGMTLVGFLRGDSMVVYSGAHRLADPAASDTDGSARSDGSASAALQTGANA
>NZ_CP040750.1|WP_138945975.1|2246867_2249159_-|FdhF/YdeP-family-oxidoreductase
MSAEPPVEDVTDADIEVTHPKHVAVGLPGILHSMEPALRQLGPKRTAELFTSINQRGGFDCMSCAWPDPDDRKKLEFCENGAKAVIWEATPVVVPSAFWAEHSLTDLADKSEYWLGMQGRLSEPVYKPAGSDHYRPVSWDEAFAIVGDQLRGQESPDEAVFYTSGRASNEAAFVYQLFVRAFGTNNLPDCSNMCHESTGTALGEVIGVGKSTIRYEDFEQADLIIVMGQNPGTNHPRMLTALEDAKQAGATIVSVNPLPEAALERYKNPQTVRGMVGRGTVISDQFLQIRLGGDMALLQAVSKRVLEAEAAAPGTILDHAFLAEHCLGLEELTAHLADLDEAAVLEATGLTSEQIDELAERYIASNATIVTWAMGLTQHKAAVNGIKEIINLLLLRGNIGKPGAGASPIRGHSNVQGDRTMGIWEQMPESFLAAMEREFAVPMPREHGVDAVNAIRAMQRGEVRTWISLGGNFVAAISDTAAAEAAIRGTQLSVQISTKLNRSHAVTGEAAIILPTLGRTEIDLQASGPQMVSVEDSVCAVHASHGRIPPAAPGLLSEVAIITRLARATLGEDSGIAWQAFEDDYDTIREHIGRVVPGCEGYNEQIRREDGFVLPNGPRDSRTFTNPEGRALLTVNELEPIHCPPGRLLLQTLRSHDQFNTTIYSLNDRYRGIKKGRNVVFVNPDDLRDLGLEDGQTVDVFSEWAGQPDRELRGFRVVSYPTARGCAAAYFPEANVLVPLDSTADRSNTPVSKAIVVRLQPAA
>NZ_CP040750.1|WP_064295863.1|2257749_2258301_-|TerD-family-protein
MASLIAGANAALTAENPGLDAVLIGFGWDVIASRGPQSEPVPLAIMCGDDGKALSDDHLVFFNQVESQDGAVTFSSEADDEEIDVELSRVPDAVSKIAFLLYIDPDVRGPGDFSPVRSAFVRVATPDGRELVRFDVPIAEVRSSQALLLAELYRHRSDWKFRALGQGYAGGLAGVARDFRIDL
>NZ_CP040750.1|WP_079704609.1|2258300_2258816_-|hypothetical-protein
MAFGRLLNALRTGGAEPLGVVDATPAPVGETEDEQTARHLDELRDSVRSVGRDLPTLLTSQLRQIDDQLRLVVATIADQGASTEQRVLLAAMVTDYLPSPLRSFLALPAADRTDDSRSTIVFARQLELIEETIRDLLNQIRIGAIAELSTHGRFLSDKFQEPDAGLVLGAH
>NZ_CP040750.1|WP_079704610.1|2258870_2260082_-|toxic-anion-resistance-protein
MSTPLTPPDANEQAAASLVLHAPDAPDVVQAEEAPGMVPVPAERQTEIQQQARSFVTEVATLDPRSPEFTQKIEGISQIGGKEMVQSSGYSSRMLDRSSTSVAGAKRSGDSAQIKVATTLGDLRSTVEDLTPNQADLGVGRKILGFIPGGNKLAKYFQKYESAQTQLDKIIKSLMAGQDELLKDNAALAGEKVQLWETMQALSEYAVFAKALDAACVAKIDEARSSGRIEEAQKLEADVLFPVRQRHQDILTQLAVSVQGYLAMDLIRKNNLELIKGVDRARTTTIAALRTAVVVAQALANQKMVLDQIDAINTTTNNMILQTSEMLKDQTTRIHQQASTAGVSVETLQRAFDNVFQTMDAIDTFRAEAAKNMEGTVNALESGLEKAKPYLERSRQAEQRELR
>NZ_CP040750.1|WP_079704611.1|2260134_2260713_-|TerD-family-protein
MAGLTLEKGNNLSLTKTSPGLTVATVGLGWDPRTTSGEAFDLDASALLVGANGKVRSSADFIFYNQPASADGSVKHLGDNRTGDGEGDDEQISVDLNAVGADVERVIIAVSIDKADERRQNFGQVRGAYCRIVDQDGTEIVRFDLSEDAAPETAMLFSELYRNGSEWKFKAVGQGYTTGLAGIAGDFGVPLG
>NZ_CP040750.1|WP_138945985.1|2260771_2261362_-|TerD-family-protein
MGLSLEKGQSLSLTKQDGGSLTRIRLGLGWDGVAPVKRGFFGRSSAPDIDLDASAIFFDATGKVLDTIWFQQLASKDGSASHTGDNLTGAGDGDDETILVDLSKVAPSVQQIVFVISSYSRQTFDTVQNAFSRIIDDSTPGSPEVARYQLTDSGPHTAMIMSKVSREGNGWTFKAIGERANGRSVMDLLGPAAQAL
>NZ_CP040750.1|WP_079704613.1|2261491_2262715_-|TerC-family-protein
MEIPGYVWLLTIVGILALLAFDFIFHVRKAHEPTLPEAAKWSALYVGIAIVFGLGVLFFGGGTLGSEYFAGYITEKALSVDNLFVFLIIMSSFRVPRADQQKVLLFGIVFALIARTGFIFLGAAAVNAWSWLFYIFGAFLIFTAIKLLRPEEESDDANNFVIRLAKRLFKTTDRYDGDKLVTIENGKKVLTPMLLVMVAIGGTDLLFALDSIPAIFGLTQNPYIVFTATAFSLLGLRQLYFLIDGLLDRLIFLSYGLAAILGFIGVKLVLHALHENTLPFLNGGEHIPVFEISTGLSLIVIIGILTVTVLASLLSPAGRAHTIISDARTQAKKIVDHADSPEDIPDGHHVDEVELETSYTRMVERQKSFANLKPKHQAKAADDEELQRLLARAHELQAKSSDSRGLL
>NZ_CP040750.1|WP_086472760.1|2262837_2263329_+|winged-helix-DNA-binding-protein
MSDDVDPAEAGAVIQASLATVLRWSTRADNRRSLHDAEGAALTATDAWLLEYVITAGPIRMSTVAGWMDVDKSTATAEVRRLEEGGLVVRATDPSDRRAVLVSATEEGRTALERHRQAAQQVYNTLVGKWSERDRAELARLLSRFVDEFSWVSDAVSQHNASR
>NZ_CP040750.1|WP_138945987.1|2263339_2263837_-|GtrA-family-protein
MVIRALPDPRALLRRPIVREVAAFGLVGGAGFLVDVGVFNLLAYTVFLHTGTSGLLVAKGISTTLAIVANWVGNRLLTFRAHRRSDVAREALEFGLVSLAGGAIALACLWVSHDAMHLTTPLADNVSANIVGLALGSAFRFVLYRFWVYGPRAERTGPIPVRIDP
>NZ_CP040750.1|WP_138945988.1|2263841_2265362_-|hypothetical-protein
MTATITVPTAPSRRRWDALHTLLGGRVAPWVVGLFATLVSLIGIGTPSYWGDEAASVLAAERPLPVMFGMIGHIDAVHGLYYAFLHVWTGAFGTAEAVTRFPSAVGVGLAAAGTVVLARALFTPAIGITAGLVFAVIPQVTRMGAETRSYALGMAAVVWLTVWFVSLVRRRSTSRRSWALFAIASAASMYLFLYLAMLLFVHATWMVLQRPGRQVMRAWGWSLVGALVLGAPIVIAGIAQREQIAFLGRRDYATPESVLVGQWFQTPAFAVLAWLLIVLAPIGVLVVRRSSRQRRALAMIAVWALAPTALLIIGNTLVTPMYNLRYVTFCVPAVAIMMALGLRTIVDLLPKQVDRAVATAAGVALVLALAIPVLAEQRGPFAKDDGSDLRQTAEVVEAHASPGDAVVFDQSVKPSRKSRLAIDLYPQAFAGLDDVALETSYRDRPELWDLAAPLSEIHDRLIGHDTVWVVEGSSTSPNVADLEALGYHVEQRIPVHRSIVFELVRS
>NZ_CP040750.1|WP_138945989.1|2265568_2266222_+|hypothetical-protein
MQLSRATALITLPVAAMLVLAGCSTPSAPDAKPTEKASSSATSKPTSTGSADGEVTEPGAQVGIDEPIVYESQGTDGVTALISAKLTEVTPATADQVAFLKTQFDGGELDGYDITLIRLEMSKVSGDPVAFNSDATSFSPVDADGEKVQEATLIGWDECGSESFTEEFDAGAPITQCYVAAAPAGGKAPAGLMYDGGFTDPNPYDSFDGDPILLIKD

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Crispr_ID: NZ_CP040750_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_14

2459565-2459662

Orphan

Consensus_repeat	Method
GAGTCGTCCGCGCTGCATGGTGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_14

>merge|NZ_CP040750|14|2459565-2459662|CRISPRCasFinder
GAGTCGTCCGCGCTGCATGGTGTTCAGTTCTCCTTGAGCATGGCGCTCTGCCTGCCGACCCCGGGGGCCGCGCTGTGTCGTCCGCGCTGCATGGTGTT

>NZ_CP040750|14|14|2459565-2459662|CRISPRCasFinder
GAGTCGTCCGCGCTGCATGGTGTT	CAGTTCTCCTTGAGCATGGCGCTCTGCCTGCCGACCCCGGGGGCCGCGCT
GTGTCGTCCGCGCTGCATGGTGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_168223381.1\|2464618_2465308_-\|phosphotriesterase	unknown	unknown	gnl\|CDD\|238295
NZ_CP040750.1\|WP_168223378.1\|2451272_2452694_-\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP040750.1\|WP_079704770.1\|2456403_2457090_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP040750.1\|WP_138946142.1\|2466685_2467636_-\|manganese-catalase-family-protein	unknown	unknown	gnl\|CDD\|226076
NZ_CP040750.1\|WP_138946139.1\|2462554_2464228_-\|potassium-transporting-ATPase-subunit-KdpA	unknown	unknown	gnl\|CDD\|235494
NZ_CP040750.1\|WP_138946132.1\|2448566_2451254_+\|family-78-glycoside-hydrolase-catalytic-domain	unknown	unknown	gnl\|CDD\|379971
NZ_CP040750.1\|WP_138947288.1\|2465576_2465990_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|131478
NZ_CP040750.1\|WP_138946143.1\|2467770_2468448_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP040750.1\|WP_138946134.1\|2454304_2455534_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NZ_CP040750.1\|WP_168223379.1\|2452728_2454294_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NZ_CP040750.1\|WP_138946131.1\|2447555_2448470_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NZ_CP040750.1\|WP_138946141.1\|2466058_2466607_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378696
NZ_CP040750.1\|WP_138947289.1\|2468586_2470257_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_CP040750.1\|WP_138946144.1\|2470307_2471474_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378641
NZ_CP040750.1\|WP_138946130.1\|2446666_2447551_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP040750.1\|WP_138946138.1\|2460302_2462468_-\|potassium-transporting-ATPase-subunit-KdpB	unknown	unknown	gnl\|CDD\|234905
NZ_CP040750.1\|WP_071261691.1\|2445295_2446597_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NZ_CP040750.1\|WP_056009336.1\|2464227_2464317_-\|K(+)-transporting-ATPase-subunit-F	unknown	unknown	unknown
NZ_CP040750.1\|WP_138946135.1\|2455796_2456249_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176859
NZ_CP040750.1\|WP_168223380.1\|2455666_2455807_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_168223381.1\|2464618_2465308_-\|phosphotriesterase	gnl\|CDD\|238295	cd00530, PTE, Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site is located next to a binuclear metal center, at the C-terminal end of a TIM alpha- beta barrel motif. The native enzyme contains two zinc ions at the active site however these can be replaced with other metals such as cobalt, cadmium, nickel or manganese and the enzyme remains active.	6.53618e-38
NZ_CP040750.1\|WP_168223378.1\|2451272_2452694_-\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	5.9587e-15
NZ_CP040750.1\|WP_079704770.1\|2456403_2457090_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.03057e-73
NZ_CP040750.1\|WP_138946142.1\|2466685_2467636_-\|manganese-catalase-family-protein	gnl\|CDD\|226076	COG3546, COG3546, Mn-containing catalase [Inorganic ion transport and metabolism].	1.47737e-78
NZ_CP040750.1\|WP_138946139.1\|2462554_2464228_-\|potassium-transporting-ATPase-subunit-KdpA	gnl\|CDD\|235494	PRK05482, PRK05482, potassium-transporting ATPase subunit A; Provisional.	0
NZ_CP040750.1\|WP_138946132.1\|2448566_2451254_+\|family-78-glycoside-hydrolase-catalytic-domain	gnl\|CDD\|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	1.99351e-135
NZ_CP040750.1\|WP_138947288.1\|2465576_2465990_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|131478	TIGR02425, putative_gamma-carboxymuconolactone_decarboxylase, 4-carboxymuconolactone decarboxylase. Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other].	4.3067e-11
NZ_CP040750.1\|WP_138946134.1\|2454304_2455534_-\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.80533e-70
NZ_CP040750.1\|WP_168223379.1\|2452728_2454294_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	3.13323e-36
NZ_CP040750.1\|WP_138946131.1\|2447555_2448470_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.92665e-66
NZ_CP040750.1\|WP_138946141.1\|2466058_2466607_+\|hypothetical-protein	gnl\|CDD\|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	5.14901e-12
NZ_CP040750.1\|WP_138947289.1\|2468586_2470257_+\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_CP040750.1\|WP_138946144.1\|2470307_2471474_+\|hypothetical-protein	gnl\|CDD\|378641	pfam11335, DUF3137, Protein of unknown function (DUF3137). This bacterial family of proteins has no known function.	0.00555608
NZ_CP040750.1\|WP_138946130.1\|2446666_2447551_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	7.25315e-66
NZ_CP040750.1\|WP_138946138.1\|2460302_2462468_-\|potassium-transporting-ATPase-subunit-KdpB	gnl\|CDD\|234905	PRK01122, PRK01122, potassium-transporting ATPase subunit KdpB.	0
NZ_CP040750.1\|WP_071261691.1\|2445295_2446597_+\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	8.74794e-33
NZ_CP040750.1\|WP_138946143.1\|2467770_2468448_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	6.51044e-41
NZ_CP040750.1\|WP_138946135.1\|2455796_2456249_-\|SRPBCC-family-protein	gnl\|CDD\|176859	cd07817, SRPBCC_8, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	6.08212e-49

>NZ_CP040750.1|WP_079704770.1|2456403_2457090_-|response-regulator-transcription-factor
MKILIADDDPQILRALRITLTARGYEIITAEDGTAALNAATTHRPDLYLLDLGMPGLDGRQVIEGLRGWTDAPILVVSGRAGSTDKVEALDAGADDYVTKPFAIDELLARIRALTRRVPGAEAEPTVRFGDIVVDLAAKQVTKQTPGASPATVRLTPTEWQVLELLIRNAGKLVTRQMLLTEIWGPTHVTDTGYLRLYIAQLRKKLEPEPATPRHLLTEAGMGYRFQL
>NZ_CP040750.1|WP_138946135.1|2455796_2456249_-|SRPBCC-family-protein
MTQVIETIDVDVPVSVAYNQWTRFEDFPKFLDEVDSITQVTDTLTEWTVSVAGQTRTFEAEITEQHPDERVAWNSTGGEADHAGVVTFHRLEDAKTRVTVQLDWEPKGLLEHLGSAVGVAGHAVKKDLGNFKQLVESEGQTGQGWRGDVE
>NZ_CP040750.1|WP_168223380.1|2455666_2455807_-|hypothetical-protein
MSSDGPRPGPPHTHDDDVKHDVPKPEEVDPEKGTDAEGDPVENPSG
>NZ_CP040750.1|WP_138946134.1|2454304_2455534_-|MFS-transporter
MSARAGQANPRPALSAPLRRRRGAIFVFMLTVGVGLSSFIVRTPAVRDLVHASTAEMGLILFGISVGSMTGILSSAALVRRFGARRPIVIGGAAFVIGLALLALMAGAGQGVGVFLGLIGIGLGFGLAEIAINIEGAMIEQLSGRSILPVLHGCYSLGSVIGSVAGIALTAIAFPVTIHLLIVATVALVALLWAIPKIPAETGRQSDTGAGSPGIRAQLAVWRQQRVIFLGLIVLALALAEGAAGDWLPLIMVDGHGTTAAVGSIVFAGFALAMTIGRFAGEPLLARFGKANVLRVSALVSAVGIALVVFSDSVLVAGLAVLLWGLGAALGFPVTLSAAGESDDPTTTVGAVASAGYVAFLVGPPLLGFLGEHFGLRGAMIVVLAVVVLASFLTSAAKPQERQVTPAGP
>NZ_CP040750.1|WP_168223379.1|2452728_2454294_+|threonine/serine-exporter-family-protein
MITSIRPLGPAHRLAQTTAEHQGEPAVTGGSYDERVGMRSLLSQLAGGVRGAAPEGVDEQAVVRLNAERPVREVLELAGRIGESMLALGAAAAEVTDAIRRVCRAFDLECQVDLTFTSILIAHDGSELSPGVTVLRVVRSPSADFDRLAKVVVVAEGITNRSEPIMTVTDVARDDEADLRDELHARLGAAHRDLDRILTARRTYRRGFVTVLLSTMAAAVAVLLGGGVVSMLLAAATTALIDSAFRALNVWKLPVFFLQLTGAAIATTVAVLISILSPYVPDDLSALPPALIVASGIVVLLAGASLVGAADDAINGFPVTASGRLVEVMLLTIGIVVGIGGVLDLARRLGISLVLFDLPVSPWPVAVQIVGAAVASAAWAMASQAALRAAFFAGVTGAIAFSVFVFVSGSGVAPAAASALAALIIGFAAEALGPRLRIPAIILTICGIVPLLPGLAIYRGMLALVNGEQGSEGVEQLLQAGLTGLALAAGVTLGEILARRTGVSGRVLLPGYIRRARRHPR
>NZ_CP040750.1|WP_168223378.1|2451272_2452694_-|DUF222-domain-containing-protein
MTETATFDGPEVHERSGYPGHPEHPSDVFAARMASFTDRFVDLARRRAALEAEEAQLLAEAFSYADATASALVSASTTSTDARDLARRSMCASLAIATRMSEPTLQARVGDAEALVHHAPAVLEALAEGSISGGHARAITDQLRDVPAEGRAVFLEQVLPVARRSTTARLRQRARVVRERLHPESFTARRTRSIFDRRVELEAAADGMAWVHLFTTAPLAHAIRNRLDAVAVPARIAGDARTLAQLRADALASLAVAGTVSDDVGPIPVDPETTGTFTWLPGSAPLDDAAKIAEEAVAAEADPLLAEPVGIEARIRATVQMTVPALSTLGVTDEPGVLDGYGPIDPDTAARLAVTAPSMTRILTQPETGAVVSVGREQYRVPADLARAVRLRDSTCRAPGCGRAARNCDLDHSVAWQDGGTTAVDNLACLCRHHHRLKHLPGWNLEHHPGGVLTWTTPDGRRHETRPELAETG
>NZ_CP040750.1|WP_138946132.1|2448566_2451254_+|family-78-glycoside-hydrolase-catalytic-domain
MTTSITATTADQAGRPPAAAAEQVTVTAPRFEHLREPLGIDVASPRLSWKLTAPSGFEPSAYQVEAVRAGGRSETDPVASSEQVLVDWPFDPLASREAAVVRVRVQGRDGAWSAWSESATVEAGLLEPSDWTAAPVGGAWEEDPEAERRPSLVRREFSLPDDVVSARLYVTAHGLAEVEINGVRIGADALAPDWTVYGERLTYRTYDVLDALRAGGNAIGAWLGDGWYRGRIGFHGGYPNLYGADLSLIAQLEVMHADGTRTTIATDADWTAGFGPILRSNLYFGEHYDAREEVAGWSLPGFDGEGFSPVAVGSRDTGTLVAPQGPPVRNTQVVSPVEVTTSPSGATVLDFGQNLVGRLRIRVSGARGTTVQLRHAEVMQDGEIYTRPLRGALATDRYTLRGPASDADAADGTDGPDHVEVWEPRFTFHGFRYAEITGWPGAFDPSAVEALVYHSDMERTGWFESSDPLLDRLHENVVWGMRGNFVGLPTDCPQRDERLGWTGDIQVFAPTASFLYDCAGFLGGWLRDVEAEQIDDGTIPWYVPVIPGGSEWTPIRPGAVWGDVAVLTPWTLFERFGDRGVLATQYESAKRWVDLVDRLAGPGHLWNTGFQLGDWLDPAAPPNDPADAATDRYLVATAYFAWSAKRLGETAAELGLTADAEHYGRLAAAVRDAFAAEYVLDSGELASDAQTAYSLGLEFGLFPTPEQRDWAGRRLAELVAAAGNRIATGFAGTPLITDALTDSGHLSTAYDLLFEDECPSWLYTVKQGGTTIWERWDSLRPDGTVNPGGMTSFNHYALGAVADWMHRTIGGLTSVAPGYRRVRIAPRPDPRLTSAAVAHESPYGRISVSWRVVGEALEVDVVVPVGVTTEIALPGAEEQVVAHGEHRFVVPVVSD
>NZ_CP040750.1|WP_138946131.1|2447555_2448470_+|ABC-transporter-permease-subunit
MTSSTLPVTAVPTKTPERRPRVSPGARRFRRGLVKLPLNVLVAVILVITIYPLFWLVISSFKTNDEFINGDAFALPSSIAWGNYVEAWTTGNMGQYLTNSALAVFPALALIIVLGTAAGFALEVMVWKGRNGVLLAFLAGIMVPGQMILLPLFTVYFQTGLSGTLWPLIITYTAIGLPLTVFMMATFFRAIPREVFEASTLDGASIIRSFFVIGFPMVRNGIFTIALVQFFFIWNDLLIALTFTNSSDLRTIQVGLLNFTGEFGATQYGPLFAAICINVFGTLVLYLVLNQRVMKGLTAGSVKG
>NZ_CP040750.1|WP_138946130.1|2446666_2447551_+|ABC-transporter-permease-subunit
MKHVLGDKRAIAILLGPALLVYTLVMLVPVIWSLGYTVFEGNAITGFTFVGVDNFVRAAGDPKVWDAVLFTVKYALVVTIGQVFIGYLMSLLYVFVLKRSSGIIRTLVFFPVVLPTVAVALLFQKMFEVAPSTGVVNTVITSFGGDSVDWFGSGTNAFLVIAIMDIWRSIGFYGVLLYAGIVEIPEDTLESARLDGATGWSLVRHIVIPLSLPVLLSAIIFSINGTLKVFDSIIALTNGGPGNATSPLTLYMFQTSFSYGEYGYGSTIALLLTIICLVVTVFIFRSSRRDLTKA
>NZ_CP040750.1|WP_071261691.1|2445295_2446597_+|extracellular-solute-binding-protein
MTRPMRRKAVLAPLAASAGALALVLTGCGGGGGSTTATSFTYLINSENTMIPGQITALSENQCKAENTALPLKVETVPQTNLDQKLQLLAGQNSLPVMYAAGNAPDLTKTLDGSGNVVDFEQALTDLDALDDIEPAAISTIKALYGGKFNVLPYQYNIEGIWYNKQIFADAGVEIPQTWDELVTAADTISKTGVTPFSASGEQGWPLTRLVGDYLFRDLGADALQKVADGDAKLTDPEYVEAAAAVADLGAKGYFGQGVGSIDYDTAAQQFLTGKAAMFYMGSWILESMNDETANQIGIDNVGFMPFPAVEGGKGSIDEYPANVGLPTTMNAKLYDDKVGDWLGCIAENYGSAALQDQGTISGFKTNTEVTGVAPLTQEIQTTISESTSSVLWFEALFSTKATTTSQTNAAQLVTGAISPEEFMQLVQADLDN
>NZ_CP040750.1|WP_138946138.1|2460302_2462468_-|potassium-transporting-ATPase-subunit-KdpB
MSTTHTLPAPAEPEQEQDHHHEPAKAAFGPAQLLAATPGAFRKLDPRLMVKNPVMFIVEAGAALTTVLAIAEPFLGGAQESGGSAVPGSFTWGIAIWLWLTVVFANLAESVAEGRGKAQADSLRKTRTSTMANQVTAYDASADPSAEHAAIGQVSSADLTLGDVVVVTAGELVPGDGDIVWGIASVDESAITGESAPVVRESGGDRSAVTGGTRVLSDRIVVRITSKPGETFVDRMIGLVEGAARQKTPNEIALNILLASLSIVFVVVALTLNPIASYAAAPVSVPVLIALLVCLIPTTIGALLSAIGIAGMDRLVQRNVLAMSGRAVEAAGDVTTLLLDKTGTITYGNRQAVEFIALRGVTPEELAQAAARSSLSDPTPEGKSIVDLAAERGIHLDGSGAGEIVPFTAQTRMSGLDQPDGAQIRKGAGSAVLAWVESFGSLAEATRAELQEHVEAVSAGGGTPLVVAQTDTTGTARVLGVVRLKDVVKAGIAERFAELRAMGIRTVMITGDNPLTAKAIAAEAGVDDFLAEATPEQKLELIRKEQEGGNLVAMTGDGTNDAPALAQADVGVAMNTGTSAAKEAGNMVDLDSDPTKLIDIVRIGKQLLITRGALTTFSIANDVAKYFAIIPAMFAGVFPGLALLNIMQLHSPASAILSAIIFNAIIIVILIPLALRGVKYRPLSASKVLSRNLLVYGLGGVIAPFIGIKLIDLVVTLIPGF
>NZ_CP040750.1|WP_138946139.1|2462554_2464228_-|potassium-transporting-ATPase-subunit-KdpA
MQTLFAILQVSTLVLVLVLLYRPLGEYLARVYTSGKDFAVERGFYRVIGVDARSEQTWQAYLRGVLAFSLVGVLLVYALQRAQAVLPFALGLPAVPEGLSFNTAASFVANTNWQSYSPEVTMGYTVQLTGLAVQNFVSAAVGIAVAIALVRGFASRRSGTIGNFWVDLTRGTLRVLLPLSVVMAVVLIAGGTIQNLNGFTDVTTITGATQTIPGGPVASQEAIKLLGTNGGGFFNANSAHPFENPTAWTSLVQNILMLAIPFSLPRTFGRMVGDHKQGYTILAVMGVIFLASFSILTALEARGLGAAPMAAGGAMEGKEQRFGVFASTLFGSTSTLTSTGAVNSMHDSYTALGGMMPMINMMLGEIAPGGVGSGLYGMLVLAVIAVFIGGLLVGRTPEYLGKKIGPREIKLASLYILVTPTLVLAGTALSFAIPGVRSDVETTSIWNPGLHGLSEVLYAFTSAANNNGSAFAGLTANTPWFNTALGVAMLLGRFVPIVLVLALAGSLAAQDRVPSTAGTLPTNRPQFVGLLTGVAVIITALTYFPVLALGPLAEGLS
>NZ_CP040750.1|WP_056009336.1|2464227_2464317_-|K(+)-transporting-ATPase-subunit-F
MIVFELLAAVLAVAAVVYLVYALVKPERF
>NZ_CP040750.1|WP_168223381.1|2464618_2465308_-|phosphotriesterase
MAATGRHLRRVYPDGAVEPTRSADELAAAFVDDVDRHGCGLIKIGVGPDRLTEDERDALRAAAVAHHATGAPIAVHLEQGAAADLVLAALDADEVDPRSIVLGHLGRNPHVEQILEAARSGAWVCLDTPSPGHPMDPARLARVLELLIDDGRLPALLLGADTTTATSRARPEEYGPAALLTTVAPQLARALGAEAVSTITRDNPARAWAFEPGDSTPEQKISPRLSATG
>NZ_CP040750.1|WP_138947288.1|2465576_2465990_-|carboxymuconolactone-decarboxylase-family-protein
MHEVFDVAAGRERLAELQDETTTAAWRATVDAAAPGFDEWIVGAVFGGTYQREGLTPRDRQLLIIGALTALGGVDPQLSGHLTTSLRIGMTRMELAEALVHLVPYVGLPRVMAALRLLPEPEPAAGPAATDRDADAR
>NZ_CP040750.1|WP_138946141.1|2466058_2466607_+|hypothetical-protein
MTTETDFRFDGGATWLNLLATQGQRFGTRPVERIGTPEAGRRWLGLVGFGVDGELSADDLHRLVRLRESLRELAMASVAGREPAPDDLAQVRGHASRSAGALWSGPAPDGVPLDAALAGIAVQALVMLQGPDRELLRQCAEVDCRWVFLDTSGRRHWCPSPACASRGRVRAHRARQGAPSAD
>NZ_CP040750.1|WP_138946142.1|2466685_2467636_-|manganese-catalase-family-protein
MYFHVQRFINEIAEDEPDPAAAAALQEGLGGQFGEMRTMMQYLFQAMNFRGPAGKPYRDLIQGIGTEEISHVELIGTTISRLLDGSPAYQGKQTDPVDQPGAGGATPLSIALSEVNTHHYLVAAQGAMPVDAAGNPWNGSWVYNSGNLVLDLLYNLMLESTGRLQKCRLYEMTSNKTARSTIAYLIVRDQAHENAYAKALETLGVNWKNSLPIPKTNAEQFPEVKLLVDQGLQSKQFSFDLAGQSEAGRIFQGMSPSNDGTELDASEQAPEGVPSTIAPERFEEFSPGADKDLLALIQATAEMELADIDATFGPLK
>NZ_CP040750.1|WP_138946143.1|2467770_2468448_-|GntR-family-transcriptional-regulator
MDTVHRESLSDQVARLLLQRIQAGEWEIGQKLPGETTLAPQLGVGRSTMREAIRQLAGQGVLSSRQGSGNFLRSRTPVQDWDALVLRTAIGSVIEARIAIECEAAALAAQRHTASDLTAIRAALAHRNADRVTIEGRVDADTALHRSIVAASGNEILTELFDTFAERSREAMIQMLRLSGEPGTDHDQLVHERIVQAVVDRDAAAAFDRSRTHLVALRDGIARSD
>NZ_CP040750.1|WP_138947289.1|2468586_2470257_+|2-isopropylmalate-synthase
MPSHRYQDLYSRVDVPLLDRTWPSRRLTEAPLWVPVDLRDGNQALAEPMDPERKRAFFELMVTMGYKEIEVGYPSASQTDYDFVRLIAETDIAPDDVTIVVFTPARRDLIERTVESIRGIRNPVVIHLYTATAPLWREVVLGHDRDSLRALILAGGSDVLEFAGDLDGVRFEFSPEVFNLTEPDYALELCDAMTTLWDASPDRPVILNLPATVEAASPNVYADQIEYMHRNLDRRDAVILSVHPHNDRGTGIACAELAVLAGAQRVEGCIFGNGERTGNVDLATLALNLHAQGVDPMIDFSDIDHIRRVVEHSNRIEIHPRHPYVGELVHTAFSGTHQDAIKKGFAEHRARAEATGSRPEDLPWRVPYLPVDPADLGRSYEAVIRVNSQSGKGGIAYLLERDYGIEMPRRLQVDFSRRVQQQADETGRELDAEALLAAFERSYLSATPSRVELLEVDVATSGETSRTTIGLRIDGDRHEATFVGIGPVEAATRLLADHGIPVEIVSLHQTSLSAGSGAEALTLLEVRRGAETVWTAGRHHSVLEASVRAVVNAASR
>NZ_CP040750.1|WP_138946144.1|2470307_2471474_+|hypothetical-protein
MELRWLTAPEHEVAAAMADERRSGRSKWVPTGRRVLFHLYFSLVLWYLAIALVSVGVSVDEYHDRRVEADDVVGLVVIVLVLVGLLVGAWLLYRWSRRPPSPKARLAEWRRHLTAVANGFEEEPKGRAMFSSLITTTGKYNNAFISTPGPQVQSHPRFVGDRVEFGNLVDDVKRSRDWHYLTVQLPAPLPHLLLDATTNDTVRSDLPPGLDRGLRISLEGDFDRWFRVYAPSGYGTDARYVLTPDVMSSLVSTAAYYNVEMVDDRVVFFSRPAADFSYAAPWVAIDAILTDLVPRLITRAERYRDERVAGQDAESVLEAARDAMEAEQVWTRKETVVGEEGRRLTVRARFHAIWVAVGAVSWLVTRTLLYIIPGAFAFAGFMSVVDGR

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Crispr_ID: NZ_CP040750_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_15

2462474-2462581

Orphan

Consensus_repeat	Method
ATGACAGCCCTTCCGCCAGGGGACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_15

>merge|NZ_CP040750|15|2462474-2462581|CRISPRCasFinder
ATGACAGCCCTTCCGCCAGGGGACCTGGCGCGAGTACGGGGAAGTGGGTGAGAGCGGTGATGATCACGCGGTGTGCGTCGTTCATGACAGCCCTTCCGCCAGGGGACC

>NZ_CP040750|15|15|2462474-2462581|CRISPRCasFinder
ATGACAGCCCTTCCGCCAGGGGACC	TGGCGCGAGTACGGGGAAGTGGGTGAGAGCGGTGATGATCACGCGGTGTGCGTCGTTC
ATGACAGCCCTTCCGCCAGGGGACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138946137.1\|2459660_2460269_-\|potassium-transporting-ATPase-subunit-KdpC	unknown	unknown	gnl\|CDD\|376890
NZ_CP040750.1\|WP_168223378.1\|2451272_2452694_-\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP040750.1\|WP_138947290.1\|2471962_2472454_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NZ_CP040750.1\|WP_079704770.1\|2456403_2457090_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP040750.1\|WP_138946142.1\|2466685_2467636_-\|manganese-catalase-family-protein	unknown	unknown	gnl\|CDD\|226076
NZ_CP040750.1\|WP_138946132.1\|2448566_2451254_+\|family-78-glycoside-hydrolase-catalytic-domain	unknown	unknown	gnl\|CDD\|379971
NZ_CP040750.1\|WP_138947288.1\|2465576_2465990_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|131478
NZ_CP040750.1\|WP_168223381.1\|2464618_2465308_-\|phosphotriesterase	unknown	unknown	gnl\|CDD\|238295
NZ_CP040750.1\|WP_138946143.1\|2467770_2468448_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP040750.1\|WP_056009336.1\|2464227_2464317_-\|K(+)-transporting-ATPase-subunit-F	unknown	unknown	unknown
NZ_CP040750.1\|WP_168223379.1\|2452728_2454294_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NZ_CP040750.1\|WP_138946145.1\|2472479_2473706_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP040750.1\|WP_138946141.1\|2466058_2466607_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378696
NZ_CP040750.1\|WP_138947289.1\|2468586_2470257_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_CP040750.1\|WP_138946144.1\|2470307_2471474_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378641
NZ_CP040750.1\|WP_138946136.1\|2457086_2459582_-\|DUF4118-domain-containing-protein	unknown	unknown	gnl\|CDD\|225115
NZ_CP040750.1\|WP_138946138.1\|2460302_2462468_-\|potassium-transporting-ATPase-subunit-KdpB	unknown	unknown	gnl\|CDD\|234905
NZ_CP040750.1\|WP_138946134.1\|2454304_2455534_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NZ_CP040750.1\|WP_138946135.1\|2455796_2456249_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176859
NZ_CP040750.1\|WP_168223380.1\|2455666_2455807_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_168223381.1\|2464618_2465308_-\|phosphotriesterase	gnl\|CDD\|238295	cd00530, PTE, Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site is located next to a binuclear metal center, at the C-terminal end of a TIM alpha- beta barrel motif. The native enzyme contains two zinc ions at the active site however these can be replaced with other metals such as cobalt, cadmium, nickel or manganese and the enzyme remains active.	6.53618e-38
NZ_CP040750.1\|WP_168223378.1\|2451272_2452694_-\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	5.9587e-15
NZ_CP040750.1\|WP_138947290.1\|2471962_2472454_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.17554e-25
NZ_CP040750.1\|WP_079704770.1\|2456403_2457090_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.03057e-73
NZ_CP040750.1\|WP_138946142.1\|2466685_2467636_-\|manganese-catalase-family-protein	gnl\|CDD\|226076	COG3546, COG3546, Mn-containing catalase [Inorganic ion transport and metabolism].	1.47737e-78
NZ_CP040750.1\|WP_138946132.1\|2448566_2451254_+\|family-78-glycoside-hydrolase-catalytic-domain	gnl\|CDD\|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	1.99351e-135
NZ_CP040750.1\|WP_138947288.1\|2465576_2465990_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|131478	TIGR02425, putative_gamma-carboxymuconolactone_decarboxylase, 4-carboxymuconolactone decarboxylase. Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other].	4.3067e-11
NZ_CP040750.1\|WP_138946137.1\|2459660_2460269_-\|potassium-transporting-ATPase-subunit-KdpC	gnl\|CDD\|376890	pfam02669, KdpC, K+-transporting ATPase, c chain. This family consists of K+-transporting ATPase, c chain, KdpC. KdpC forms strong interactions with the KdpA subunit, serving to assemble and stabilize the Kdp complex. It has been suggested that KdpC could be one of the connecting links between the energy providing subunit KdpB and the K+-transporting subunit KdpA. The K+ transport system actively transports K+ ions via ATP hydrolysis.	4.68923e-94
NZ_CP040750.1\|WP_138946134.1\|2454304_2455534_-\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.80533e-70
NZ_CP040750.1\|WP_168223379.1\|2452728_2454294_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	3.13323e-36
NZ_CP040750.1\|WP_138946145.1\|2472479_2473706_-\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	2.13646e-71
NZ_CP040750.1\|WP_138946141.1\|2466058_2466607_+\|hypothetical-protein	gnl\|CDD\|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	5.14901e-12
NZ_CP040750.1\|WP_138947289.1\|2468586_2470257_+\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_CP040750.1\|WP_138946144.1\|2470307_2471474_+\|hypothetical-protein	gnl\|CDD\|378641	pfam11335, DUF3137, Protein of unknown function (DUF3137). This bacterial family of proteins has no known function.	0.00555608
NZ_CP040750.1\|WP_138946136.1\|2457086_2459582_-\|DUF4118-domain-containing-protein	gnl\|CDD\|225115	COG2205, KdpD, Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms].	0
NZ_CP040750.1\|WP_138946138.1\|2460302_2462468_-\|potassium-transporting-ATPase-subunit-KdpB	gnl\|CDD\|234905	PRK01122, PRK01122, potassium-transporting ATPase subunit KdpB.	0
NZ_CP040750.1\|WP_138946143.1\|2467770_2468448_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	6.51044e-41
NZ_CP040750.1\|WP_138946135.1\|2455796_2456249_-\|SRPBCC-family-protein	gnl\|CDD\|176859	cd07817, SRPBCC_8, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	6.08212e-49

>NZ_CP040750.1|WP_138946138.1|2460302_2462468_-|potassium-transporting-ATPase-subunit-KdpB
MSTTHTLPAPAEPEQEQDHHHEPAKAAFGPAQLLAATPGAFRKLDPRLMVKNPVMFIVEAGAALTTVLAIAEPFLGGAQESGGSAVPGSFTWGIAIWLWLTVVFANLAESVAEGRGKAQADSLRKTRTSTMANQVTAYDASADPSAEHAAIGQVSSADLTLGDVVVVTAGELVPGDGDIVWGIASVDESAITGESAPVVRESGGDRSAVTGGTRVLSDRIVVRITSKPGETFVDRMIGLVEGAARQKTPNEIALNILLASLSIVFVVVALTLNPIASYAAAPVSVPVLIALLVCLIPTTIGALLSAIGIAGMDRLVQRNVLAMSGRAVEAAGDVTTLLLDKTGTITYGNRQAVEFIALRGVTPEELAQAAARSSLSDPTPEGKSIVDLAAERGIHLDGSGAGEIVPFTAQTRMSGLDQPDGAQIRKGAGSAVLAWVESFGSLAEATRAELQEHVEAVSAGGGTPLVVAQTDTTGTARVLGVVRLKDVVKAGIAERFAELRAMGIRTVMITGDNPLTAKAIAAEAGVDDFLAEATPEQKLELIRKEQEGGNLVAMTGDGTNDAPALAQADVGVAMNTGTSAAKEAGNMVDLDSDPTKLIDIVRIGKQLLITRGALTTFSIANDVAKYFAIIPAMFAGVFPGLALLNIMQLHSPASAILSAIIFNAIIIVILIPLALRGVKYRPLSASKVLSRNLLVYGLGGVIAPFIGIKLIDLVVTLIPGF
>NZ_CP040750.1|WP_138946137.1|2459660_2460269_-|potassium-transporting-ATPase-subunit-KdpC
MSASRSGIAQYWVAIRAMLALTVVLGVGYPLVVTGIGQATMSWQANGSAVTEGGKTVGSALIGQSFTDADGKPLPQWFQSRPSAAGDGYDGGASSGSNLGPENTDLVASIEERRAAIASFEDVDPSTIPADALTASASGLDPHISPAYALLQVPRVAAERGLDEGEVRALIERLTQGPDLGYLGESTVNVLQLNLAVAGLDG
>NZ_CP040750.1|WP_138946136.1|2457086_2459582_-|DUF4118-domain-containing-protein
MQRGRLRVLLGAAPGVGKTYAMLEEGHRLASEGVDVVVAVVETHGRAATAALTEGLETLPRRGVEHRGVTLDEMDLEAVLARRPGLALVDELAHTNAPGSTNDKRWQDVEALLAAGVSVLSTVNIQHIESLNDVVRQITGAPQRETIPDAVLRAADQIELIDLAPQALRDRLAGGRVYPAERIDAALSNYFRLGNLTALRELALLWLADEVDSALRDYRAEHGIDSTWEARERVVVALTGGPEGETLLRRGARIAARSSGGELIAVHVTTQDGLRTANPGALAQQRALVDTLGGTFHQVVGDDVPRALVDFAKAANATQLVIGVSRRSRLSAAVTGPGIGNTVIRESGNIDVHIVNHEAAGGRFRLPKLGGALSARRHIAGFALALIGGPLVTWLLHLARTEESITSEVLSYQLLVVLVALVGGFWPAVFAAVLSGVTLDFVFVQPLYTVTIDDPAHLVALVLYVVIAVIVSGVVDLSARRARTARRAAAESELLATVAGSVLRGEGALQALVSRTRESFSLAGVRLVAGEQVLAVDGEPTRGGDFTSIPIGTRAVLELHGGVLAASDRRLLAVIAAQLDASLEHTDLRATAQEVGPLAATDRVRSALLSAVSHDLRRPLAAATAAVTGLRATDVELTTADRQDLLETADDSLRTLAALVTNLLDVSRLQAGVLAVTVAPIDVEDAILPAFDELGIGPHDAELDLAPDLPPVLADAGLLQRVIVNLLTNAQRFSPDDTPVRIATSGFRDAVEIRIVDHGPGIAPDRREDVFVPFQRLGDTDNLTGLGLGLALSKGFVEGMGGTLEPEDTPGGGLTMVVSLPAARDQEGTAR
>NZ_CP040750.1|WP_079704770.1|2456403_2457090_-|response-regulator-transcription-factor
MKILIADDDPQILRALRITLTARGYEIITAEDGTAALNAATTHRPDLYLLDLGMPGLDGRQVIEGLRGWTDAPILVVSGRAGSTDKVEALDAGADDYVTKPFAIDELLARIRALTRRVPGAEAEPTVRFGDIVVDLAAKQVTKQTPGASPATVRLTPTEWQVLELLIRNAGKLVTRQMLLTEIWGPTHVTDTGYLRLYIAQLRKKLEPEPATPRHLLTEAGMGYRFQL
>NZ_CP040750.1|WP_138946135.1|2455796_2456249_-|SRPBCC-family-protein
MTQVIETIDVDVPVSVAYNQWTRFEDFPKFLDEVDSITQVTDTLTEWTVSVAGQTRTFEAEITEQHPDERVAWNSTGGEADHAGVVTFHRLEDAKTRVTVQLDWEPKGLLEHLGSAVGVAGHAVKKDLGNFKQLVESEGQTGQGWRGDVE
>NZ_CP040750.1|WP_168223380.1|2455666_2455807_-|hypothetical-protein
MSSDGPRPGPPHTHDDDVKHDVPKPEEVDPEKGTDAEGDPVENPSG
>NZ_CP040750.1|WP_138946134.1|2454304_2455534_-|MFS-transporter
MSARAGQANPRPALSAPLRRRRGAIFVFMLTVGVGLSSFIVRTPAVRDLVHASTAEMGLILFGISVGSMTGILSSAALVRRFGARRPIVIGGAAFVIGLALLALMAGAGQGVGVFLGLIGIGLGFGLAEIAINIEGAMIEQLSGRSILPVLHGCYSLGSVIGSVAGIALTAIAFPVTIHLLIVATVALVALLWAIPKIPAETGRQSDTGAGSPGIRAQLAVWRQQRVIFLGLIVLALALAEGAAGDWLPLIMVDGHGTTAAVGSIVFAGFALAMTIGRFAGEPLLARFGKANVLRVSALVSAVGIALVVFSDSVLVAGLAVLLWGLGAALGFPVTLSAAGESDDPTTTVGAVASAGYVAFLVGPPLLGFLGEHFGLRGAMIVVLAVVVLASFLTSAAKPQERQVTPAGP
>NZ_CP040750.1|WP_168223379.1|2452728_2454294_+|threonine/serine-exporter-family-protein
MITSIRPLGPAHRLAQTTAEHQGEPAVTGGSYDERVGMRSLLSQLAGGVRGAAPEGVDEQAVVRLNAERPVREVLELAGRIGESMLALGAAAAEVTDAIRRVCRAFDLECQVDLTFTSILIAHDGSELSPGVTVLRVVRSPSADFDRLAKVVVVAEGITNRSEPIMTVTDVARDDEADLRDELHARLGAAHRDLDRILTARRTYRRGFVTVLLSTMAAAVAVLLGGGVVSMLLAAATTALIDSAFRALNVWKLPVFFLQLTGAAIATTVAVLISILSPYVPDDLSALPPALIVASGIVVLLAGASLVGAADDAINGFPVTASGRLVEVMLLTIGIVVGIGGVLDLARRLGISLVLFDLPVSPWPVAVQIVGAAVASAAWAMASQAALRAAFFAGVTGAIAFSVFVFVSGSGVAPAAASALAALIIGFAAEALGPRLRIPAIILTICGIVPLLPGLAIYRGMLALVNGEQGSEGVEQLLQAGLTGLALAAGVTLGEILARRTGVSGRVLLPGYIRRARRHPR
>NZ_CP040750.1|WP_168223378.1|2451272_2452694_-|DUF222-domain-containing-protein
MTETATFDGPEVHERSGYPGHPEHPSDVFAARMASFTDRFVDLARRRAALEAEEAQLLAEAFSYADATASALVSASTTSTDARDLARRSMCASLAIATRMSEPTLQARVGDAEALVHHAPAVLEALAEGSISGGHARAITDQLRDVPAEGRAVFLEQVLPVARRSTTARLRQRARVVRERLHPESFTARRTRSIFDRRVELEAAADGMAWVHLFTTAPLAHAIRNRLDAVAVPARIAGDARTLAQLRADALASLAVAGTVSDDVGPIPVDPETTGTFTWLPGSAPLDDAAKIAEEAVAAEADPLLAEPVGIEARIRATVQMTVPALSTLGVTDEPGVLDGYGPIDPDTAARLAVTAPSMTRILTQPETGAVVSVGREQYRVPADLARAVRLRDSTCRAPGCGRAARNCDLDHSVAWQDGGTTAVDNLACLCRHHHRLKHLPGWNLEHHPGGVLTWTTPDGRRHETRPELAETG
>NZ_CP040750.1|WP_138946132.1|2448566_2451254_+|family-78-glycoside-hydrolase-catalytic-domain
MTTSITATTADQAGRPPAAAAEQVTVTAPRFEHLREPLGIDVASPRLSWKLTAPSGFEPSAYQVEAVRAGGRSETDPVASSEQVLVDWPFDPLASREAAVVRVRVQGRDGAWSAWSESATVEAGLLEPSDWTAAPVGGAWEEDPEAERRPSLVRREFSLPDDVVSARLYVTAHGLAEVEINGVRIGADALAPDWTVYGERLTYRTYDVLDALRAGGNAIGAWLGDGWYRGRIGFHGGYPNLYGADLSLIAQLEVMHADGTRTTIATDADWTAGFGPILRSNLYFGEHYDAREEVAGWSLPGFDGEGFSPVAVGSRDTGTLVAPQGPPVRNTQVVSPVEVTTSPSGATVLDFGQNLVGRLRIRVSGARGTTVQLRHAEVMQDGEIYTRPLRGALATDRYTLRGPASDADAADGTDGPDHVEVWEPRFTFHGFRYAEITGWPGAFDPSAVEALVYHSDMERTGWFESSDPLLDRLHENVVWGMRGNFVGLPTDCPQRDERLGWTGDIQVFAPTASFLYDCAGFLGGWLRDVEAEQIDDGTIPWYVPVIPGGSEWTPIRPGAVWGDVAVLTPWTLFERFGDRGVLATQYESAKRWVDLVDRLAGPGHLWNTGFQLGDWLDPAAPPNDPADAATDRYLVATAYFAWSAKRLGETAAELGLTADAEHYGRLAAAVRDAFAAEYVLDSGELASDAQTAYSLGLEFGLFPTPEQRDWAGRRLAELVAAAGNRIATGFAGTPLITDALTDSGHLSTAYDLLFEDECPSWLYTVKQGGTTIWERWDSLRPDGTVNPGGMTSFNHYALGAVADWMHRTIGGLTSVAPGYRRVRIAPRPDPRLTSAAVAHESPYGRISVSWRVVGEALEVDVVVPVGVTTEIALPGAEEQVVAHGEHRFVVPVVSD
>NZ_CP040750.1|WP_056009336.1|2464227_2464317_-|K(+)-transporting-ATPase-subunit-F
MIVFELLAAVLAVAAVVYLVYALVKPERF
>NZ_CP040750.1|WP_168223381.1|2464618_2465308_-|phosphotriesterase
MAATGRHLRRVYPDGAVEPTRSADELAAAFVDDVDRHGCGLIKIGVGPDRLTEDERDALRAAAVAHHATGAPIAVHLEQGAAADLVLAALDADEVDPRSIVLGHLGRNPHVEQILEAARSGAWVCLDTPSPGHPMDPARLARVLELLIDDGRLPALLLGADTTTATSRARPEEYGPAALLTTVAPQLARALGAEAVSTITRDNPARAWAFEPGDSTPEQKISPRLSATG
>NZ_CP040750.1|WP_138947288.1|2465576_2465990_-|carboxymuconolactone-decarboxylase-family-protein
MHEVFDVAAGRERLAELQDETTTAAWRATVDAAAPGFDEWIVGAVFGGTYQREGLTPRDRQLLIIGALTALGGVDPQLSGHLTTSLRIGMTRMELAEALVHLVPYVGLPRVMAALRLLPEPEPAAGPAATDRDADAR
>NZ_CP040750.1|WP_138946141.1|2466058_2466607_+|hypothetical-protein
MTTETDFRFDGGATWLNLLATQGQRFGTRPVERIGTPEAGRRWLGLVGFGVDGELSADDLHRLVRLRESLRELAMASVAGREPAPDDLAQVRGHASRSAGALWSGPAPDGVPLDAALAGIAVQALVMLQGPDRELLRQCAEVDCRWVFLDTSGRRHWCPSPACASRGRVRAHRARQGAPSAD
>NZ_CP040750.1|WP_138946142.1|2466685_2467636_-|manganese-catalase-family-protein
MYFHVQRFINEIAEDEPDPAAAAALQEGLGGQFGEMRTMMQYLFQAMNFRGPAGKPYRDLIQGIGTEEISHVELIGTTISRLLDGSPAYQGKQTDPVDQPGAGGATPLSIALSEVNTHHYLVAAQGAMPVDAAGNPWNGSWVYNSGNLVLDLLYNLMLESTGRLQKCRLYEMTSNKTARSTIAYLIVRDQAHENAYAKALETLGVNWKNSLPIPKTNAEQFPEVKLLVDQGLQSKQFSFDLAGQSEAGRIFQGMSPSNDGTELDASEQAPEGVPSTIAPERFEEFSPGADKDLLALIQATAEMELADIDATFGPLK
>NZ_CP040750.1|WP_138946143.1|2467770_2468448_-|GntR-family-transcriptional-regulator
MDTVHRESLSDQVARLLLQRIQAGEWEIGQKLPGETTLAPQLGVGRSTMREAIRQLAGQGVLSSRQGSGNFLRSRTPVQDWDALVLRTAIGSVIEARIAIECEAAALAAQRHTASDLTAIRAALAHRNADRVTIEGRVDADTALHRSIVAASGNEILTELFDTFAERSREAMIQMLRLSGEPGTDHDQLVHERIVQAVVDRDAAAAFDRSRTHLVALRDGIARSD
>NZ_CP040750.1|WP_138947289.1|2468586_2470257_+|2-isopropylmalate-synthase
MPSHRYQDLYSRVDVPLLDRTWPSRRLTEAPLWVPVDLRDGNQALAEPMDPERKRAFFELMVTMGYKEIEVGYPSASQTDYDFVRLIAETDIAPDDVTIVVFTPARRDLIERTVESIRGIRNPVVIHLYTATAPLWREVVLGHDRDSLRALILAGGSDVLEFAGDLDGVRFEFSPEVFNLTEPDYALELCDAMTTLWDASPDRPVILNLPATVEAASPNVYADQIEYMHRNLDRRDAVILSVHPHNDRGTGIACAELAVLAGAQRVEGCIFGNGERTGNVDLATLALNLHAQGVDPMIDFSDIDHIRRVVEHSNRIEIHPRHPYVGELVHTAFSGTHQDAIKKGFAEHRARAEATGSRPEDLPWRVPYLPVDPADLGRSYEAVIRVNSQSGKGGIAYLLERDYGIEMPRRLQVDFSRRVQQQADETGRELDAEALLAAFERSYLSATPSRVELLEVDVATSGETSRTTIGLRIDGDRHEATFVGIGPVEAATRLLADHGIPVEIVSLHQTSLSAGSGAEALTLLEVRRGAETVWTAGRHHSVLEASVRAVVNAASR
>NZ_CP040750.1|WP_138946144.1|2470307_2471474_+|hypothetical-protein
MELRWLTAPEHEVAAAMADERRSGRSKWVPTGRRVLFHLYFSLVLWYLAIALVSVGVSVDEYHDRRVEADDVVGLVVIVLVLVGLLVGAWLLYRWSRRPPSPKARLAEWRRHLTAVANGFEEEPKGRAMFSSLITTTGKYNNAFISTPGPQVQSHPRFVGDRVEFGNLVDDVKRSRDWHYLTVQLPAPLPHLLLDATTNDTVRSDLPPGLDRGLRISLEGDFDRWFRVYAPSGYGTDARYVLTPDVMSSLVSTAAYYNVEMVDDRVVFFSRPAADFSYAAPWVAIDAILTDLVPRLITRAERYRDERVAGQDAESVLEAARDAMEAEQVWTRKETVVGEEGRRLTVRARFHAIWVAVGAVSWLVTRTLLYIIPGAFAFAGFMSVVDGR
>NZ_CP040750.1|WP_138947290.1|2471962_2472454_+|helix-turn-helix-domain-containing-protein
MVALIAGMGCPQAAGRPRAGDTVICSRIATTIVSAALRTWNEAGCAPDRWLQRIGDPHIGAVLDALHAEPGRPWTFETLARIAMMSRSAFAERFREVVGHTPRAYLTTVRMETAKGLILTGDATVAELAGALGYVSEDGFARAFQRYTGLTPARWRVEAALAA
>NZ_CP040750.1|WP_138946145.1|2472479_2473706_-|MFS-transporter
MTTDEKLDAPRTGSVPTTNTAASDAPHTRTAWAAVAVMMATSFVLVLAEFLPPSLLPSMASSLGITEGQAGQAVTATAFIGFLTAPTIGILVPRLDRRLLLVLLAAAAAVSSALVAISADFVMLLIARLLLGAALGAFWAMSIAIAARLSAPHHLGRAIMLVNTGTTVATVAGVPVGTYLGSVMDWRLIFAGVAVITAVVAVALRLVLPPVAPAPSSGGLRSLVDTLRVPGIRVGLTGHILTVLGHFIAFTYIRLAIERVPDLDAAGVAVLLAAFGLGGVVGNFVIGLLVDRHLAALRYVVPAFIGISIALVTLFPGQPWIVTIAITTWGMGFGAWLTTLSTWMGRLVPDRMESGGGLVVAGFQLAITVGAGAGGLLVDAVGIVPALTVAAISAIVGGIVFGSARTAR

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Crispr_ID: NZ_CP040750_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_16

2519199-2519609

Orphan

Consensus_repeat	Method
CCCTTCGACAGGCTCAGGGACCG	PILER-CR

5 spacers

The CRISPR arrays of NZ_CP040750_16

>merge|NZ_CP040750|16|2519199-2519609|PILER-CR
CCCTTCGACAGGCTCAGGGACCGGGGCGTTCCGGGCGCACTTCTTCCGGTCACTGAGCCTGTCGAAGTGCGCACGAGGAACCCTTCGACAGGCTCAGGGACCGGGTGCATCCGGGTGATCCTCTTCGGTTGACCGAGGTTGCGCGGCTTGGCTGCCCTTCGACAGGCTCAGGGACCGAAATGGTTCGGGCGCACTTCTTCCGGTCACTGAGCTTGTCGAAGTGCGCACGAGGAACCCTTCGACAGGCTCAGGGACCGGGTGCATCCGGGTGATCCTCTTCGGTTGACCGAGGTTGCGCGGCTTGGCTGCCCTTCGACAGGCTCAGGGACCGAAATGGTTCGGGCGCACTTCTTCCGGTCACTGAGCTTGTCGAAGTGCGCACGAGGAACCCTTCGACAGGCTCAGGGACCG

>NZ_CP040750|16|1|2519199-2519609|PILER-CR
CCCTTCGACAGGCTCAGGGACCG	GGGCGTTCCGGGCGCACTTCTTCCGGTCACTGAGCCTGTCGAAGTGCGCACGAGGAA
CCCTTCGACAGGCTCAGGGACCG	GGTGCATCCGGGTGATCCTCTTCGGTTGACCGAGGTTGCGCGGCTTGGCTG
CCCTTCGACAGGCTCAGGGACCG	AAATGGTTCGGGCGCACTTCTTCCGGTCACTGAGCTTGTCGAAGTGCGCACGAGGAA
CCCTTCGACAGGCTCAGGGACCG	GGTGCATCCGGGTGATCCTCTTCGGTTGACCGAGGTTGCGCGGCTTGGCTG
CCCTTCGACAGGCTCAGGGACCG	AAATGGTTCGGGCGCACTTCTTCCGGTCACTGAGCTTGTCGAAGTGCGCACGAGGAA
CCCTTCGACAGGCTCAGGGACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138946181.1\|2522294_2522942_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP040750.1\|WP_138946180.1\|2521720_2522152_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138946175.1\|2515081_2515588_+\|sodium:proton-antiporter	unknown	unknown	unknown
NZ_CP040750.1\|WP_056009243.1\|2525705_2526503_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NZ_CP040750.1\|WP_138946178.1\|2518308_2518914_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP040750.1\|WP_138946183.1\|2524836_2525709_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP040750.1\|WP_138946173.1\|2511518_2512997_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_CP040750.1\|WP_138946182.1\|2523074_2524733_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173874
NZ_CP040750.1\|WP_085512050.1\|2530925_2531228_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138946184.1\|2528533_2530846_+\|beta-glucosidase	unknown	unknown	gnl\|CDD\|185053
NZ_CP040750.1\|WP_138946179.1\|2519919_2521191_-\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP040750.1\|WP_138947292.1\|2513742_2515011_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
NZ_CP040750.1\|WP_138946174.1\|2513029_2513614_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176854
NZ_CP040750.1\|WP_138946172.1\|2510514_2511513_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235935
NZ_CP040750.1\|WP_056009241.1\|2526499_2527483_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP040750.1\|WP_079704857.1\|2527484_2528537_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP040750.1\|WP_085512058.1\|2516110_2516650_+\|flavin-reductase	unknown	unknown	gnl\|CDD\|376575
NZ_CP040750.1\|WP_138946176.1\|2515628_2516051_+\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|238608
NZ_CP040750.1\|WP_138947293.1\|2516650_2517607_-\|proline-dehydrogenase	unknown	unknown	gnl\|CDD\|376577
NZ_CP040750.1\|WP_138946177.1\|2517715_2518288_+\|bacteriocin-protection-protein,-YdeI/OmpD-associated-family	unknown	unknown	gnl\|CDD\|226851

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138946181.1\|2522294_2522942_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.44216e-10
NZ_CP040750.1\|WP_138946172.1\|2510514_2511513_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235935	PRK07109, PRK07109, short chain dehydrogenase; Provisional.	2.58008e-151
NZ_CP040750.1\|WP_056009243.1\|2525705_2526503_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	7.53168e-106
NZ_CP040750.1\|WP_138946178.1\|2518308_2518914_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	1.94896e-20
NZ_CP040750.1\|WP_138946183.1\|2524836_2525709_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.8847e-118
NZ_CP040750.1\|WP_138946173.1\|2511518_2512997_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	8.5651e-83
NZ_CP040750.1\|WP_138946182.1\|2523074_2524733_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173874	cd08509, PBP2_TmCBP_oligosaccharides_like, The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold. This family represents the substrate-binding domain of a cellulose-binding protein from the hyperthermophilic bacterium Thermotoga maritima (TmCBP) and its closest related proteins. TmCBP binds a variety of lengths of beta-1,4-linked glucose oligomers, ranging from two sugar rings (cellobiose) to five (cellopentose). TmCBP is structurally homologous to domains I and III of the ATP-binding cassette (ABC)-type oligopeptide-binding proteins and thus belongs to the type 2 periplasmic binding fold protein (PBP2) superfamily. The type 2 periplasmic binding proteins are soluble ligand-binding components of ABC or tripartite ATP-independent transporters and chemotaxis systems. Members of the PBP2 superfamily function in uptake of a variety of metabolites in bacteria such as amino acids, carbohydrate, ions, and polyamines. Ligands are then transported across the cytoplasmic membrane energized by ATP hydrolysis or electrochemical ion gradient. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	9.33448e-133
NZ_CP040750.1\|WP_138946184.1\|2528533_2530846_+\|beta-glucosidase	gnl\|CDD\|185053	PRK15098, PRK15098, beta-glucosidase BglX.	5.76862e-163
NZ_CP040750.1\|WP_138946179.1\|2519919_2521191_-\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	5.80555e-17
NZ_CP040750.1\|WP_138947292.1\|2513742_2515011_+\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.03092e-49
NZ_CP040750.1\|WP_138946174.1\|2513029_2513614_+\|SRPBCC-family-protein	gnl\|CDD\|176854	cd07812, SRPBCC, START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket; they bind diverse ligands. Included in this superfamily are the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), as well as the SRPBCC domains of phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of this superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	6.57612e-08
NZ_CP040750.1\|WP_056009241.1\|2526499_2527483_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.03004e-101
NZ_CP040750.1\|WP_079704857.1\|2527484_2528537_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.80197e-71
NZ_CP040750.1\|WP_085512058.1\|2516110_2516650_+\|flavin-reductase	gnl\|CDD\|376575	pfam01613, Flavin_Reduct, Flavin reductase like domain. This is a flavin reductase family consisting of enzymes known to be flavin reductases as well as various oxidoreductase and monooxygenase components. VlmR is a flavin reductase that functions in a two-component enzyme system to provide isobutylamine N-hydroxylase with reduced flavin and may be involved in the synthesis of valanimycin. SnaC is a flavin reductase that provides reduced flavin for the oxidation of pristinamycin IIB to pristinamycin IIA as catalyzed by SnaA, SnaB heterodimer. This flavin reductase region characterized by enzymes of the family is present in the C-terminus of potential FMN proteins from Synechocystis sp. suggesting it is a flavin reductase domain.	6.98115e-36
NZ_CP040750.1\|WP_138946176.1\|2515628_2516051_+\|HIT-domain-containing-protein	gnl\|CDD\|238608	cd01277, HINT_subgroup, HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.	7.06549e-33
NZ_CP040750.1\|WP_138947293.1\|2516650_2517607_-\|proline-dehydrogenase	gnl\|CDD\|376577	pfam01619, Pro_dh, Proline dehydrogenase.	2.13126e-26
NZ_CP040750.1\|WP_138946177.1\|2517715_2518288_+\|bacteriocin-protection-protein,-YdeI/OmpD-associated-family	gnl\|CDD\|226851	COG4430, COG4430, Uncharacterized protein conserved in bacteria [Function unknown].	1.63365e-38

>NZ_CP040750.1|WP_138946178.1|2518308_2518914_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MRVSPGTVWPVVHEERRRLVADLSMMGEEQWGTPSLCSGWDVHDVVAHLVDSAKTTRLGFARRLIAARFDFDLDNARGVERERRNDPQETLRALADAAELTCTPPANLATRLVEAIVHGEDVRRPLGIRADYPTAAVLVALEYQLRTGVSMGGGKERAQGVRLVAEDTGTSWGEGDEVRGSALDLLLAVSGRPTGLALPGR
>NZ_CP040750.1|WP_138946177.1|2517715_2518288_+|bacteriocin-protection-protein,-YdeI/OmpD-associated-family
MASFEEKPILDLTLDEWEAYLAGAPSDAGVRLKLRKKTSKASGITWSEALDVALCYGWIDGQSKRLDDDYTLQAFTPRRKSSPWSQINREHVARLIEEGRMRPGGLAEIERAKADGRWDVAYRQKDAVAPDDLQVALDANPEAAAYFATLKRTERFRVFFRLSNIKTPAVRAARIADVVEKAARGEQHYR
>NZ_CP040750.1|WP_138947293.1|2516650_2517607_-|proline-dehydrogenase
MNDETLSRAADTLRAWALDEDLKARVLAHPEAAAVAKRAALRYIAGEDAASALRLLEANADRGHRWSIELVGESVRDARVADEQTAEFIDLARRISESDQTATISLDLSHIGSVVSPELGLRNGLALAQAARDAGTSLMISAEGSDRTDLVLSIYEQIADAFPETGITLQARLHRTPADLDRVLDRPGPIRVVKGAFLESTEVAYPRDSAPMTAAYLSMVTRLVGSGHRVNLATHDANLVAALEGALGDDLRQPHVEFEMLQGLGTELLDDLRRRGFTTREYLVYGPEWWLYVLNRIAEHPERVIEAIADIGPIALLA
>NZ_CP040750.1|WP_085512058.1|2516110_2516650_+|flavin-reductase
MTIPTTPSADPDALARAATVDGFKTAFRDHPAGVALISASTDRGDVGLTASSVASVAVDPPMLSFSVTRATGSAGGLLSAGTVVVHLLADHHLEVAKAFAKTGEPRFTPEQHWERLATGEPYLPSARAALRCRIVQTVPAGSSMLVIAEVLEVVPPGTDAPALVYQNRNFHRLESDPLG
>NZ_CP040750.1|WP_138946176.1|2515628_2516051_+|HIT-domain-containing-protein
MPETCTFCRILRDEPDDITWVEREDEAVAFRPLPESELAPGHTLVVPRAHSVGLLDADPRALQATTALAQRVGRAMRAALGATGVVVLSASGADAGQSVPHLHLHVVPCWDDDGVTFWPEGRSKHRVDGDPHELLAEMFE
>NZ_CP040750.1|WP_138946175.1|2515081_2515588_+|sodium:proton-antiporter
MPDGKDTADASPGDGRDETLNERSDRNWSELLQEFRVLQTGTQILAGFLLTLPFQPRFTELTGFDHVLYLALVILAVTVTLLALAPVIMHRLVFRQLAKPQLVRLSSRILMVCLGAASLLFAGIVLFVFDFVASPAVGLWAGGAVVVVIGLVWIVGPRLIRGARDRVS
>NZ_CP040750.1|WP_138947292.1|2513742_2515011_+|amino-acid-permease
MLYLFILGDVLGAGIYALIGQIAGEVGGVTWVPMIVALLLALLTAASYAELVTKYPKAGGSAVFAERAYKRPIISFLVGYCMLAAGVVSASGLALAFAGDYLATFIDLPPVLGAVLFLLVIALINARGIKESVRANLVMTMIETTGLVLVVVAVAMMLGGGRGDLGRATQFAEGGSPVIAVFGAALLAYYSFVGFETSANVIEEVKDPSRVYPKALFGALATAGVLYVLVGTAASIAVPSDELGESTGPLLTVIQATGVGIPAWLFSIIALVAVANGALLTMIMSSRLAYGMGSQGLLPSVFTKVLPKRGTPWVAIIVTTGVAMVLTATGSIATLAETVVLLLLIVFLSTNIAVLVLRRERVEHAHFRAWTVLPVLAVLSCLVLLTQQSAEVWLRGGIIVVVGVVLYAITRVVRRRKAPEAA
>NZ_CP040750.1|WP_138946174.1|2513029_2513614_+|SRPBCC-family-protein
MSHTTRILDCPPDRVFAVLADGWLFPAWVVGASRMRDVGDRWPHVGGKLHHSFGVWPAVLNDETTVLQWDAPHRFVIQPKGWPLGEARVAVEVEPHERGCIIHLHEHAVTGPGALIPVWLLDIGLHLRNIETLRRLAHLAEGGAGGTHLVEAAEPTAADRKNAEFPKRSLFARVASVLVVAVPVVAVARKLLRG
>NZ_CP040750.1|WP_138946173.1|2511518_2512997_+|FAD-dependent-oxidoreductase
MARREQFDAVVVGAGPNGLAAAVTLARAGLHVQVVERGDTIGGGARTAELTLPGFHHDICSAVHPMALASGFFRSFGLERRIDLVVPEISYAHPLDGGRAGIAYRDIDRTADALGRDGDAWRSLMGPLAADADRVSQFTGGKLLQVPRHPVTVARFGLRALEQGSPAWNLRFREETAPAMLSGVAAHSIRPMPSLSTSAAALSLGAYAHARGWPIPVGGSQAIVDALAADLLAHGGEIVTGTEVRSIDELPSARAVLFDTTPKALAEIAGSRLPDAYLRRLSRFRYGDGVAKVDFALSGPVPWTNPELARAGTLHLGGTRPEIAAAERDVARGRHSESPYVLVSQPDVGDPGRAPGDAQVLWAYTHVPSGSGLDQTEAIIRQIERFAPGFRDVILTSASMTARDMARYNPNYVLGDIAAGAASFAQLVARPVLSNDPWRTPTPGIFLCSSSTPPGPGVHGLAGWHAARSALRSVFGRDRMPSLAPDRPRPNS
>NZ_CP040750.1|WP_138946172.1|2510514_2511513_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSRGVAVVTGGTAGLGRATVRELAARGWDVAVLARGEDGLAATIAEVEQAGRRGLGVPTDVADREAVEHAADRVEAELGPIELWVNCAMVGVFGDFLTTEPADFERAVAVNFFGFVNGTRAALSRMVPRDRGHVIQVGSALAHRGIPLQAAYCGSKFGARGFTESVTAELLHDGSNVKLSTVDMPALNTIQFSWVKSQLPEHPQPVPPIYQPEVGATAIADVADRPRRRTWVGESTVGTILGDRFAGGFLDWFLARTGYSGQLAPDKDDPRMPDNVYTPAPGDHGARGVFSDKAHSWSPQTWAIRHRRAVYATAAGTLAAGVAMVAGAAKRR
>NZ_CP040750.1|WP_138946179.1|2519919_2521191_-|DUF222-domain-containing-protein
MTETTSAAIRVCDEHAAQLAEFSDQWAELHRQQAVLDARKTRLLARSAAYADAFADATVPAIFPPAERQALSRRSTCAALAMATRTPERTIQRATNDAERLVNDAPAVLESLEAGRISARHAQVITDQLSDVPTTGRAAFLEQVLPVAESTTVSYLQQRARVIRERLHPESITARAVRSEADRRVEFEPAADGMAWVHLFTTAPIAQGLVERVEAAAAESRAAGDTRTCAQLQADALAALALTGVTPEDVMSSPVLPHPIEVQEHITPTVQITVPALSMAGVSDAPATLDGYGPIDPETAARIAVNAPSFTRILVQPETGAVLSVGRNQYRVPADLQRAVRLRDGTCRAPGCGRRARACDLDHSVAWEDGGTTDVGNLACLCRHHHRMKHLPGWNLDHRPGGVLDWTTPDGKHHRTEPDPAPF
>NZ_CP040750.1|WP_138946180.1|2521720_2522152_-|hypothetical-protein
MAEKQSSTKSGFSAEERAAMKERAKELKAAASREEALQAVVDAIADMEDADRAIAEPLHELIMGGDSGLAAKTWYGMPAYVGADGKAVVFFQAAAKFKARYATIGFNDSAKLDDGDLWPTAFGVTAWNDAVAKRVAELLARAV
>NZ_CP040750.1|WP_138946181.1|2522294_2522942_-|TetR-family-transcriptional-regulator
MSTVKRQNTAKRPAQPRPATVARRAEVVRSALDVFGAKGYANGTLIDIAELVDMTPAGILHHFGSKDQLLLEVLSYRDATDVQDLDDQHIPGGIDLFKHLIRTAAANAQRAGIVQAFVVLSAESVTEDHPARHYFDDRYRTLRREIAEAFEVVCAERGVDAPETIHRAAASILAVMDGLQVQWLIDPADVDLAETSEYAIRVIVESVLEPGALDG
>NZ_CP040750.1|WP_138946182.1|2523074_2524733_+|ABC-transporter-substrate-binding-protein
MKLRTPLLAAFAATALLLTGCTGGGGSSDGPESGAALTIAKPDGSIATESNNPYVGDSSAMKLGYINAILEPLAIVNLVDPSAEVKPWLASEIAWSDDYTSVALTARDGVTWNDGEAFSADDIAFTFQQFIDHPELDNSALGLTSVATEGDTVTLSFTNPMFVKQDKVLLKQIVPKHVWESVDDPATFENPEPVGTGPYTLTSFSTESVELTARDDYWGEQPAVPTLYYVSYNDNTALTTALANGDADWAQAFIPNVQSAYLDKDKEHNVYWAAAGLAVDAMFVNTQTKPFNDPAFRQAVNLVIDREQHQQIAREGGVPELSSVTGLPTPAGDAFIASEFEGEDYTVDAKAAKQVLTDAGYTWEDDVLTDPSGEAVTFTLSVPQGWNDYVTGISLIADSVKTLGVTATVDTPDQDTWWAAKSDGDFQAILHWTDTGATPYDLYSDIMDGRWLVAEGEAADFNFGRYDSPEATAALAAYANATDDATRTAALETVQKLFVSDVPAMPIGTRPFIGSYNTRNYTGWPSEDDPYAPADPTQPTAVYILTQLKAAK
>NZ_CP040750.1|WP_138946183.1|2524836_2525709_+|ATP-binding-cassette-domain-containing-protein
MTNDDLLTVSSFSVTYDVEPPVEAVRDVSLTLRRGEILGLAGESGCGKTTLAYGLQRLLKPPAVITGGTAVFHDESGEDIDLGRLGEEEMRAFRWDKASMVFQGAMNALNPVTSIGRQLDDVFTTHRRGMSRAERREEAGKLLDIVGVGRDRLKSYPHELSGGMRQRVMIAMALALKPQLMIMDEPTTALDVLVQREILQQISELRTEFGFSVIFITHDLPLLLEISDRIAVMRAGRLVEIDTAERIYRQAKDPYTRKLLASFPSLTGERGDFVRGTGAATSATQAGVTA
>NZ_CP040750.1|WP_056009243.1|2525705_2526503_+|ABC-transporter-ATP-binding-protein
MTTLEFSHVSKRYRVRGSGHMLALDDVSFTLRSGQTLALVGQSGSGKSTIAKILTQLERATSGDILLDGKAIPRRGRALRRYRQQVRMVFQDPFASLNPSHTIRHHLERPLRLDHVVPEAEVEDEVHRLLERVQLDPAGTIDRRPHELSGGQRQRVAIARALASRPSLLIADEPVSMLDVSIRLGVLNLLAELQRESQLGVLYITHDLATARHFSDEIMVLHHGEVVERGPADDVILRPQHPYTLALRNASPDPDRHFAGTETIA
>NZ_CP040750.1|WP_056009241.1|2526499_2527483_+|ABC-transporter-permease
MTFFLRRAAFYAFTAWAAITINFFLPRMLKGDPVSAYIAKNQGRISPEAADSLRTLFGLDADKSMLEQYLDYWRLLFSGDLGRSFSKGLAPVTDVIAAALPWTVGLVGIATILSFVLGTSIGALIGWRRGSKADFIVPLSTFFSTVPYFWMGLIAIAVFSTLLGWFPASHAYGKGSRPEFTLDFIGQVIAHGFLPAATIVLASLGGWILGMRNMMVTVLDEDYVTVAQAKGLPTRRVLVDYAARNAMLPQLSSFALSLGFIVGGTIVMEMVFSYPGVGKLLLDATTAKDYPLMQGLFLVITLTVLVANILADVAYAVLDPRTRQMES
>NZ_CP040750.1|WP_079704857.1|2527484_2528537_+|ABC-transporter-permease
MTIPTTEALATAEAPKPTPAGRSFAARFASSFAMFRNGKSIAGLCILGFFVLVAVFGDLIAPYGPLEKDFTALRQAPSAAHLLGTTHMGEDVLSQLIYGTRGVLLVGFLAGIFATIIAVAIGVTAGYVSGFTSESLSALTNVFLVIPGLPLMIIVASQYDNPSLFLIAGVLALTGWAWGGRVLRAQTMSLRNRDFIQAAKANGESLFRIITVEMLPNLTAIIASSFVGTVTAAVLGLTTLAFIGVIPITNLNWGTILFWAQQNGAFPDFWWWYVPAGVCIALLGVALSLINFGIDEYVNPRLRSAGERARALRKRGIKPGASVTAVRTETTGPSTITDTTHTERAGATER
>NZ_CP040750.1|WP_138946184.1|2528533_2530846_+|beta-glucosidase
MKTDTAPHLEDARYLDATLPIAARVDDLVERMTVREKVGQMMQLDARDDIEAHVLETHVGSILHASPERLAVAHELVGRTRLRIPLIVGEDCIHGHSFHLGATIFPTQLAMAASWDAELLERVARATAVEVAATGVHWTFSPVLCIARDLRWGRVGETFGEDPFLIGELASAMVRGYQGDGLSDPTAILATAKHFAGYSETQGGRDASEADISPRKLRSWFLPPFERVAREGCASFMLGYQSIDGVPITVNEWLLNDVLRGEWGYEGTLITDWDNVGRMVWEQHVSPDYVHASAAAIRAGNDMVMTTPGFFAGALEALERGLLEEADLDRAVRRILTLKFALGLFELPRHPDAAEQLAVIGSPEHTELNLETARRSLVLLRNKGVLPLAGGYRADEAGRAIATPEAGPQRIAVVGPLADDAQMQLGDWAGNSGQAGWLPDGQPREMITTVVDGLRAVAPAGSTVTTAFGADILTLSPDPAGATFPDGQPRPPLVTPARPDEALIAEAVALAEDADVVVAVVGDRIELVGEGRSTATLELIGGQVALLDALAATGKPLVVVLLASKPLVLPPSALHADAIVWAASPGMQGGRAIAELLLGLIEPTGRLPISFARHAGQQPTYYNQIRGQHGDRYADLTQEPAFAFGDGLSYSSVEYGEPRLDQVVYGRDATVRAEVEVHNSGSRPVLETVQVYVSDLVTSVSWADQELKTFRQVAIEPGDTATVTIELPVADCSIVDARGRRVVEAGEFELRVGGSSRADALHAVRFTIAD
>NZ_CP040750.1|WP_085512050.1|2530925_2531228_-|hypothetical-protein
MGAIVYGTGENRFHLEDRMLAHVKTITLMKLRRNESFSVTLRDTSTERGRVTLWLHPSIPLQFSFDSDETFEMDRPLLEDLMHGANGGEVTVRADADELA

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Crispr_ID: NZ_CP040750_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_17

2722063-2722123

Orphan

Consensus_repeat	Method
GAGCCCGCCACCGGTCCCTGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_17

>merge|NZ_CP040750|17|2722063-2722123|CRISPRCasFinder
GAGCCCGCCACCGGTCCCTGAGCCCAACTCCGGTCCCTGAGCCCAACTCCGGTCCCTGAGC

>NZ_CP040750|17|16|2722063-2722123|CRISPRCasFinder
GAGCCCGCCACCGGTCCCTGAGC	CCAACTCCGGTCCCT
GAGCCCAACTCCGGTCCCTGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138946320.1\|2720952_2722050_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP040750.1\|WP_138946319.1\|2720143_2720956_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224098
NZ_CP040750.1\|WP_138947308.1\|2728448_2729735_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138946315.1\|2715567_2715861_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225080
NZ_CP040750.1\|WP_138946321.1\|2722153_2723308_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP040750.1\|WP_138946318.1\|2718069_2719179_+\|solute-binding-protein	unknown	unknown	gnl\|CDD\|270267
NZ_CP040750.1\|WP_168223395.1\|2715903_2717019_+\|lactonase-family-protein	unknown	unknown	gnl\|CDD\|378416
NZ_CP040750.1\|WP_064295554.1\|2714247_2715534_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NZ_CP040750.1\|WP_138946322.1\|2723435_2723750_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138946323.1\|2723852_2724761_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP040750.1\|WP_138946317.1\|2717068_2717701_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP040750.1\|WP_138946327.1\|2732070_2733012_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235737
NZ_CP040750.1\|WP_138946325.1\|2727513_2728446_-\|zinc-ABC-transporter-solute-binding-protein	unknown	unknown	gnl\|CDD\|376518
NZ_CP040750.1\|WP_064295553.1\|2713242_2713995_-\|HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319784
NZ_CP040750.1\|WP_138947306.1\|2719325_2720147_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226616
NZ_CP040750.1\|WP_138947307.1\|2724841_2726152_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NZ_CP040750.1\|WP_138946326.1\|2731467_2731812_+\|chorismate-mutase	unknown	unknown	gnl\|CDD\|181719
NZ_CP040750.1\|WP_138947309.1\|2730773_2731406_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224046
NZ_CP040750.1\|WP_138946324.1\|2726237_2727485_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138946314.1\|2712686_2713163_+\|DUF3151-family-protein	unknown	unknown	gnl\|CDD\|378646

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138946320.1\|2720952_2722050_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	2.63142e-150
NZ_CP040750.1\|WP_138946319.1\|2720143_2720956_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	3.91164e-26
NZ_CP040750.1\|WP_138946315.1\|2715567_2715861_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225080	COG2169, Ada, Adenosine deaminase [Nucleotide transport and metabolism].	1.47042e-07
NZ_CP040750.1\|WP_138946321.1\|2722153_2723308_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	6.12314e-40
NZ_CP040750.1\|WP_138946318.1\|2718069_2719179_+\|solute-binding-protein	gnl\|CDD\|270267	cd13549, PBP2_Fbp_like_3, Substrate binding domain of an uncharacterized ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. This periplasmic domain (Fbp) has high affinity for ferric iron and serves as the primary receptor for transport. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.47625e-31
NZ_CP040750.1\|WP_168223395.1\|2715903_2717019_+\|lactonase-family-protein	gnl\|CDD\|378416	pfam10282, Lactonase, Lactonase, 7-bladed beta-propeller. This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyze 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.	1.14971e-53
NZ_CP040750.1\|WP_064295554.1\|2714247_2715534_+\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NZ_CP040750.1\|WP_138946323.1\|2723852_2724761_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	6.67919e-87
NZ_CP040750.1\|WP_138946317.1\|2717068_2717701_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	4.04469e-18
NZ_CP040750.1\|WP_138946327.1\|2732070_2733012_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	4.8662e-65
NZ_CP040750.1\|WP_064295553.1\|2713242_2713995_-\|HAD-IIB-family-hydrolase	gnl\|CDD\|319784	cd02585, HAD_PMM, phosphomannomutase, similar to human PMM1 and PMM2, Saccharomyces Sec53p, and Arabidopsis thaliana PMM. PMM catalyzes the interconversion of mannose-6-phosphate (M6P) to mannose-1-phosphate (M1P); the conversion of M6P to M1P is an essential step in mannose activation and the biosynthesis of glycoconjugates in all eukaryotes. M1P is the substrate for the synthesis of GDP-mannose, which is an intermediate for protein glycosylation, protein sorting and secretion, and maintaining a functional endomembrane system in eukaryotic cells. Proteins in this family contains a conserved phosphorylated motif DxDx(T/V) shared with some other phosphotransferases. This family contains two human homologs, PMM1 and PMM2; PMM2 deficiency causes congenital disorder of glycosylation type I-a, also known as Jaeken syndrome. PMM1 can also act as glucose-1,6-bisphosphatase in the brain after stimulation with inosine monophosphate; PMM2 on the other hand, is insensitive to IMP and demonstrates low glucose-1,6-bisphosphatase activity. Arabidopsis thaliana PMM converted M1P into M6P and glucose-1-phosphate into glucose-6-phosphate, with the latter reaction being less efficient. Arabidopsis thaliana and Nicotiana benthamian PPMs are involved in ascorbic acid biosynthesis. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.21384e-40
NZ_CP040750.1\|WP_138947306.1\|2719325_2720147_+\|ABC-transporter-permease-subunit	gnl\|CDD\|226616	COG4132, COG4132, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.18122e-68
NZ_CP040750.1\|WP_138947307.1\|2724841_2726152_+\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	2.52213e-06
NZ_CP040750.1\|WP_138946326.1\|2731467_2731812_+\|chorismate-mutase	gnl\|CDD\|181719	PRK09239, PRK09239, chorismate mutase; Provisional.	5.12801e-47
NZ_CP040750.1\|WP_138947309.1\|2730773_2731406_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	5.9502e-69
NZ_CP040750.1\|WP_138946325.1\|2727513_2728446_-\|zinc-ABC-transporter-solute-binding-protein	gnl\|CDD\|376518	pfam01297, ZnuA, Zinc-uptake complex component A periplasmic. ZnuA includes periplasmic solute binding proteins such as TroA that interacts with an ATP-binding cassette transport system in Treponema pallidum. ZnuA is part of the bacterial zinc-uptake complex ZnuABC, whose components are the following families, ZinT, pfam09223, pfam00950, pfam00005, all of which are regulated by the transcription-regulator family FUR, pfam01475. ZinT acts as a Zn2+-buffering protein that delivers Zn2+ to ZnuA (TroA), a high-affinity zinc-uptake protein. In Gram-negative bacteria the ZnuABC transporter system ensures an adequate import of zinc in Zn2+-poor environments, such as those encountered by pathogens within the infected host.	1.33853e-80
NZ_CP040750.1\|WP_138946314.1\|2712686_2713163_+\|DUF3151-family-protein	gnl\|CDD\|378646	pfam11349, DUF3151, Protein of unknown function (DUF3151). This family of proteins with unknown function appears to be restricted to Actinobacteria.	8.77851e-52

>NZ_CP040750.1|WP_138946320.1|2720952_2722050_+|ATP-binding-cassette-domain-containing-protein
MTTIDQSAPAATPGDGRLAGAAVRFDRVVKDYGSGARALDGVSLDLAPGEFVALLGPSGCGKTTALRSLAGLEDITSGSVLIDGVDVVSVPTNRRDLGMVFQSYSLFPHLTVLENVEFGLRMRKVPAAERRTRAAESLDLVGLGHLAARYAHQLSGGQQQRVALARALVTRPRVLLLDEPLSALDAKVRVQLRDEIRRIQSELQITTLFVTHDQEEALAVADRVAVMRAGVIEQIGTPEELYSRPSSPFVAEFIGLSNRIPGELVPGGVEVLGQVLPVIGEQPGDGAVVALVRPEDVVFTDATEPAVGSAAVVLTSSFLGPVRRTTVELPDGTLVAVQHGATERLEAGESVRIRFAGRPVPVQTA
>NZ_CP040750.1|WP_138946319.1|2720143_2720956_+|ABC-transporter-permease-subunit
MSAVRDSATPSKLTSRIILVVVAVVFAVPILSMVEFTLRAGIDGGHDLGHWAAILDPENSRKYRVLFQGIGNSVVLAAVTVLIVVVLLLPTMILVKLRFPKLQRVLEFVCIIPITVPAIVLVVGLAPVYSVVAKLLGSAPWTLAFAYGITVLPYAYRAIAANLQSVDVGTLAEAARTLGADWGTVLVRVLLPNLRRGVLTASVISVAVVLGEYTIASLLGRNTLQTSLVQVSKSDPFVAVAFALLALAFAFVLLFIIGRVGSIRRIRETP
>NZ_CP040750.1|WP_138947306.1|2719325_2720147_+|ABC-transporter-permease-subunit
MTPFALYALLFLAVPTFLALATGFFDGDGAFTLDNLTALAEPAVLGAFASSFWVSAVTAVAGAVIGALVCYALLAVRPDGLIRTFVDAASSVLAQFGGVMLAFAFIATIGIQGLVTVFLKDRLGVDLFADGVWLYQVPGLLLPYLYFQVPLMVITFMPAMEGLKRTWSEANATLGGTRLTYWTRIAMPILAPSFLGSLLLLFANAFSSYATAAALISQGAQIVPLQIRGALISETVLGRENLAGSLAIGMIVVMVVMMTAYSALQARTERWQR
>NZ_CP040750.1|WP_138946318.1|2718069_2719179_+|solute-binding-protein
MTALAIVALAATALTACSAGADTGAGSDVDAKQATSAEDFGGMDALVKAAKAEGQLNVIALPDTWANYGKIISAFEDKYDITVNSADPDVSSAEEITAAKNQQGQDTAPDVFDLGSAVALDNLDQFAPYQVANWDDIPEGSKEKTGLWVYDYTGLVSIGYDADAVPAPKSLDDLLGSEFAGKVALNGDPTQAGAAAAGVYLAALQSGGSADDIQPGVDFFQKLNQAGNFLPLDPTPATIASGETPVVIDWSYNNLAAATENEGQRNWKTTVLPGSAVGSYYNQAINVDAPHPAAARLWQEFIFSPEAQNLYLAAGAYPSTLAAMVEADTVDQKALDAVGEMPADLVQFTPEQTEQATSLLAEKWAAAIS
>NZ_CP040750.1|WP_138946317.1|2717068_2717701_+|GNAT-family-N-acetyltransferase
MTARRPEPRPIDGRTIRLEPLDRAHYPELFTAIAHPEVFAGGYGGGPAGLPTTQAEFDAFADGYFTTGVRNTYVIRLVGGEHDGLLVGTSTLGDFDEPGEAAHLGWTAYDPRVWGTAVNAETKLLLLGLAFDAGFGRVKIQADERNERSRTAILRLGATFEGLIRRDKQRADGTWRTTALFSVLAEEWPEVRAGLEERLTRSPGPVALRG
>NZ_CP040750.1|WP_168223395.1|2715903_2717019_+|lactonase-family-protein
MSDDNPYLLLGSYTSEADGTGAGISLLRQDEAGTLRLVQSSEAQSPSFLTLHPTLPIVYAASESTGAVEAFKRSGEFGLAPFGKPIEAGGSVCHVATVPGADVLIASCYGDGRVVTVPLAENAAFAGDPRLGEASVDSWASPTALAAESADAGEDALTLLALEAAVGEALPSRPSRAHASALLPDGRIATTDLGHDTVRIWQLRGSRLVLDHTVVFPRGTGPRHLVVHPSGHLHVITEYSVEVFTLGVDGTDGHWHILAATVATSEGVSEGDTGAEISLAASREQLHVGVRGSDRIATLRVTGDGSRVEAVADVECGGTMPRHHRESGRFLHVANQLSNSIASFRLDERTGVPTTLLGTLDAGSPTCLILA
>NZ_CP040750.1|WP_138946315.1|2715567_2715861_+|winged-helix-turn-helix-transcriptional-regulator
MVDESSQPSLPGLPPVEELTNGEVRPRPAVRAQRDAGALDPRVRRALATLDDDPDLSLVTLANALGITRATLIRIVREAIGMTPKEYAAGVRARRIS
>NZ_CP040750.1|WP_064295554.1|2714247_2715534_+|adenylosuccinate-synthase
MPAIVIVGAQWGDEGKGKATDLLGDRIDYVVKFNGGNNAGHTVVIGDEKYALHLLPSGILTSGVVPVISNGVVIDIEVLFHELEALQARGIDVSRLLVSANAHVITQYHRTIDKVTERFLGKRQIGTTGRGIGPAYADKINRVGIRIQDLFDENILRQKVEGALDQKNHLLVKVFNRRAITVDEIVADLLAYAERLRPMVADTALVLNEALDDGKIVLFEGGQATMLDVDHGTYPFVTSSNATSGGAATGSGVAPNRLDRVIGIVKAYTTRVGAGPFPTELFDESGDYLRSKGFEFGTTTGRPRRVGWYDAPIARYAARINGVTDFVLTKLDILDDLATIPVCVAYEVDGVRVDEVPVSQTDFHHAVPIYEEFPGWQEDITGVRRFEDLPKNAQDYVLALEAMSGSRISAIGVGPGRDAIVVRHDLVD
>NZ_CP040750.1|WP_064295553.1|2713242_2713995_-|HAD-IIB-family-hydrolase
MTSLPRLVAFDLDDTLAPSKSALDPRMAELFVALLERTSVCIISGGQIVQFQNQVLDRLGAASPEALGRLHLMPTCGTRYDRFDGTAWVTVYKHDLTDDQKARAMGALETEAKRLGLWADETWGPILEDRGSQITFSALGQAAPVAEKTAWDPDGAKKESLRAAVQALLPDLEVRSGGSTSVDITMAGVDKAFGMTRLAEHTGIPLEEMVFVGDRLDEGGNDYPVLALGVPSVAVHGWQDTAAYLESLGL
>NZ_CP040750.1|WP_138946314.1|2712686_2713163_+|DUF3151-family-protein
MTGENLMATPPTLLPDDSATDAEFHAAVGSIEALADLLAAHPRSSLGWALLADAVHDPQSPIPGYAAARVGYHRGLDSLRAAGWRGQGPIPWSHAPNRGVLRSLYALRRSAKAIGETEEVERLDTFLREADPTASDEIEYLVAAAAPPTSAIVILGSD
>NZ_CP040750.1|WP_138946321.1|2722153_2723308_-|AI-2E-family-transporter
MTSAPHRHQPLRPAARQQRVRFRAHRPAAVTTAVRTTLQRPFAIGFVGALGALAAILLVLTLGSLSTILVSIAVGLFIALGLDPVVVRLEARGIKRPFAIAIVFAVFAVLLALLLALVIPVVTRQAVELVSNAPAFLTGIQDQEWFRSLSDYLGPGVDLQGALDWLYGVAADPKTWVVLAGGALNLGIGIANGFFGGFIALVLALYFLASMQAMKNAFYSLVPRRSRPRVVSITDQITASIGGYVSGMVVLAGINAVLGLIMMLIVGVPYAGILAVVIFFVTLIPLVGSIIATVVVATVGLFDSPTTALIVIVYYLVYMQIESYVLTPRVMNKAVAVPGALVVIGAMVGGSLIGLLGALVSIPVTASILLIIKQVVVPRQNAKA
>NZ_CP040750.1|WP_138946322.1|2723435_2723750_+|hypothetical-protein
MSSITRSHAVHTRVTAPLRAVPLTEPVPSRGDEATEQGVVAERVSATAHVAAGAAGVDLTASVEPTQAPAAGTGGTDAGTGLRFLGAGWAADAAVFAQYRRRGN
>NZ_CP040750.1|WP_138946323.1|2723852_2724761_+|ATP-binding-cassette-domain-containing-protein
MNTSILSARGLTKQYGPTVALAGVDLDILPGESVAIMGASGSGKTTLMHALAGIVTPDTGSIAFNTPTGVVRVDQLDERHRSQLRRESFGFVFQQGLLIPELTAVENVAIALMLGGTPRIAAETSAAAWLAALGLAGMETRRIGELSGGQAQRVAIARAQVTGAPIVFADEPTGALDSRTSADVMGALLHATTGQGRTLVLVTHDETVAARCSRTIRLADGRIVGQPGGVGAPTPPQQFATGQAPVPQQMQQPYPPQQLPYQQQPAGQPFPQQPYAQPAAQPYPPQAYPGQATGVVQNGARP
>NZ_CP040750.1|WP_138947307.1|2724841_2726152_+|FtsX-like-permease-family-protein
MLARPGAQSPATIVLPAVAFAVTTALVLTVLGGAMMFWRWTGETAFIYQVLSVLALALLLVPLGSLGGAAARLSARRRDDRLATLRLLGATPGTVTAMTVLESAGVALLGAFAGILLYLGMLPLVGLIPFGGSPIGVEGVWVGVPIIAAVVLGVVLLAAASAAIGLRAVNVSPLGVRTKQQAPTVHWLRIVVGAVVVIVAYGMLSVVTGLQEVAAIVAVLGVGFAAGVGVLGLIGPWVVGVIGRGSAKRAKTPERLLAARTILESPKAAWRQVSGVAMTSFVAVVAGTGVALMDAAGGSELDRESAILIDDIRTGVIITLVASFLMVACSVGVNQASAVLDRRDLYVSLDRLGVPRDVMERARGRAVMLPLRVVALGSAGLGVLLVLPMASISVILAPLSVLVIVGCFAGGIGLVWAALRATRPVVSGVLRAPERV
>NZ_CP040750.1|WP_138946324.1|2726237_2727485_-|hypothetical-protein
MQQHHRSPLAPRLKRGRVPFLAVGTAAALLLTGCSTASGSAPDPSASTSADPQSRITLTYDGGLLVLDAASLEVVGDLPLAGFNRVNAAGDGRHVLVTTTKGFQVLDTGTWTDEDGTSKQADPVLTDLVFPADTAGHVVRHADKTILFADGSGDTTIFDSADLLEATDELPETETIPSEAAHHGVAIELEDGTVLSTIGTPDARTGVRVLDDSRTEIARNEQCPSVHGEGTVKDEVVVFGCSDGVLVYDSGVFTKIQAPDAYGRTGNQYVSETSSIAVGDYNSDPDAEGYDLRQLAFTDTVTKTTKIVDLPEGVGYTWRDVARGPSDEVIVLGNDGSLHILDEQTGAVTDTIEVIDAWEPPAEWQDAHPALVVQDGVAYVTDPATKSIHAVDLASGDITTGELPGVPNEIAVVTG
>NZ_CP040750.1|WP_138946325.1|2727513_2728446_-|zinc-ABC-transporter-solute-binding-protein
MRATIPRTTVLLRTTAVLAAGLVLGTGLTSCAASADDRPLVVVTTNILGDVVGELVGDQAEVMTLMPPDADPHSFEISARQAARITGAQLLVSNGLGLEEGLTQHLETAADEGVPIVEAGSLVDVLETASGASDPHFWTDPTQMTSVVDGVTEALLEEIPTLDAAELQANAATYTAELEALDAEMAEAFAAIPAEQRKLVTNHHVFGYLAARYDFQVIGAVIPSGTTLAAPSASDLDELSTAIEEAGVRTIFADSSQPDRLVQVLADEADVDVAVVPLFTESLTAESGDAPTYLTMMRANTERIATGLSP
>NZ_CP040750.1|WP_138947308.1|2728448_2729735_-|hypothetical-protein
MRPTDDRLTRATRTALALGALALTLSACAPQGSASPTATASDEPRGHGYVEGASELPEPQLHLATADVDGTVELTDLLSEERTTLAELGPISALTGDGRFVAAQSEPAGTVTIIDTGVWTVDHEDHQHYYRAEARVVGEIEGDGQATITAGSTTTAVRFAGSGETLLLDTAALGTGDITQSGRIRTSPGAPGITVPIGETVVATDGTGKLHLHGLDGDLLDPSSASVTAADAVLAGCTDPAGSITTNVGVVIGCAEGAVLAVVDRSSGEADPVPTFEAIPYPQAVAAADRATSFHARPGRPTVAAVAGTSGAWLLDTRERSWALLPTPTPLQLVTAVDDRDQHVVGLTTTGDLLVIDGATGSVTGTAAALVGAADLATGVQLEVDQNRAYLNTPGTRTVSEIDYGDAARIARTFTFDTAPAFLAETGR
>NZ_CP040750.1|WP_138947309.1|2730773_2731406_+|ATP-binding-cassette-domain-containing-protein
MRLHDVSAEYDGARVLHGISVEVGAAAITVVTGANGAGKSTLLAVIAGLHRPTSGGVDGLDGRSAAYVPQRSAVPERFPVTVRDVASMGRWPTLRRWWGRLGAGDRRIVDESLARLDVLHLAGRSFGELSGGQRQRVLVAQALAREADLLLLDEPTVGLDRAAGLAIREVLRAEADRGATVVEVTHDPVAVAEADARVHLEAGRLVEGPR
>NZ_CP040750.1|WP_138946326.1|2731467_2731812_+|chorismate-mutase
MSQAEQEPESTTAAPAADDQAATERLGRLRSSIDNIDAALVHLLAERFKCTQEVGRLKAEHDMPASDPAREQRQITRLRALAEESHLDPAFAEKWFNFVVAEVIHHHERLANQH
>NZ_CP040750.1|WP_138946327.1|2732070_2733012_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTWNADSLPDQTGRVVLVTGANAGLGFWTSLGLARAGAEVILASRSATKTQAAMRAIRVKVPDARLGHLPFDTSSLDSVRSAGERLAGLDRLDALVANAGMVHMPKERQETADGIELVFATNVVGHAALLAEALPVLQRTADAHDSAPRVVLLGSLSTLLVRFHGDDLQLRDGYSGWQAYAQSKIALSSLGFELDRRLAASHSTVRALVAHPGYSVNGLDRRVPGVNEPTRGRRFSDTLQSVYAQSKQRGAEPTLRAVTDESADGGWFFGPQWLTKGDAVRQTPAAITTDRDVAAALWTDLERLIGTPILPAS

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Crispr_ID: NZ_CP040750_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_18

2768554-2768892

Orphan

Consensus_repeat	Method
CCCTTCGACAGGCTCAGGGACCG	PILER-CR

4 spacers

The CRISPR arrays of NZ_CP040750_18

>merge|NZ_CP040750|18|2768554-2768892|PILER-CR
CCCTTCGACAGGCTCAGGGACCGGGGCCATCCGGGTGCTCCTCTCCCGCTCATCGAGGCGGCGCGAACCGAGTGCCCTTCGACAGGCTCAGGGACCGAAAGCTTGCGAGCGCAGTCCAGCCCGGTCACTGAGCCTGTCGAAGTGCCCACGAAGAACCCTTCGGCAGGCTCAGGGACCGAATCGGTTCCGGGTGCACCTCTCCCGGTCACTGAGCTTGTCGAAGTGCCCACGAGGAACCCTTCGACAGGCTCAGGGACCGAAATGGTTCGGGTGCACTTCCTCCGGTCACTGAGCTTGTCGAAGTGCCCACGAGGAACCCTTCGACAAGCTCAGGGACCG

>NZ_CP040750|18|2|2768554-2768892|PILER-CR
CCCTTCGACAGGCTCAGGGACCG	GGGCCATCCGGGTGCTCCTCTCCCGCTCATCGAGGCGGCGCGAACCGAGTG
CCCTTCGACAGGCTCAGGGACCG	AAAGCTTGCGAGCGCAGTCCAGCCCGGTCACTGAGCCTGTCGAAGTGCCCACGAAGAA
CCCTTCGGCAGGCTCAGGGACCG	AATCGGTTCCGGGTGCACCTCTCCCGGTCACTGAGCTTGTCGAAGTGCCCACGAGGAA
CCCTTCGACAGGCTCAGGGACCG	AAATGGTTCGGGTGCACTTCCTCCGGTCACTGAGCTTGTCGAAGTGCCCACGAGGAA
CCCTTCGACAAGCTCAGGGACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138946360.1\|2775246_2776605_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366721
NZ_CP040750.1\|WP_138946363.1\|2780832_2781654_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379258
NZ_CP040750.1\|WP_138946350.1\|2759211_2759823_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380217
NZ_CP040750.1\|WP_138946359.1\|2772556_2774134_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP040750.1\|WP_064294182.1\|2772191_2772452_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl\|CDD\|235659
NZ_CP040750.1\|WP_168223398.1\|2769041_2770316_-\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP040750.1\|WP_138946356.1\|2767493_2768381_-\|NAD-binding-protein	unknown	unknown	gnl\|CDD\|224995
NZ_CP040750.1\|WP_138946353.1\|2762913_2764617_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238625
NZ_CP040750.1\|WP_064294172.1\|2759974_2760193_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378012
NZ_CP040750.1\|WP_138946355.1\|2766243_2767497_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215463
NZ_CP040750.1\|WP_138946354.1\|2765802_2766177_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP040750.1\|WP_079705049.1\|2774130_2775027_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NZ_CP040750.1\|WP_138946351.1\|2760268_2761045_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP040750.1\|WP_138946362.1\|2780059_2780836_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377939
NZ_CP040750.1\|WP_064294181.1\|2771493_2772195_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	unknown	unknown	gnl\|CDD\|235140
NZ_CP040750.1\|WP_138946349.1\|2758606_2759215_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138947310.1\|2762018_2762897_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270225
NZ_CP040750.1\|WP_138946361.1\|2776888_2778355_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143421
NZ_CP040750.1\|WP_138946352.1\|2761041_2762016_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
NZ_CP040750.1\|WP_138946358.1\|2770588_2771296_-\|FCD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225097

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138946363.1\|2780832_2781654_+\|hypothetical-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	2.72137e-15
NZ_CP040750.1\|WP_138946350.1\|2759211_2759823_+\|hypothetical-protein	gnl\|CDD\|380217	NF033218, anchor_AmaP, alkaline shock response membrane anchor protein AmaP. The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.	0.00113744
NZ_CP040750.1\|WP_138946359.1\|2772556_2774134_-\|amino-acid-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.47108e-29
NZ_CP040750.1\|WP_138946360.1\|2775246_2776605_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	2.29337e-79
NZ_CP040750.1\|WP_168223398.1\|2769041_2770316_-\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	4.53107e-17
NZ_CP040750.1\|WP_138946356.1\|2767493_2768381_-\|NAD-binding-protein	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	6.90976e-61
NZ_CP040750.1\|WP_138946353.1\|2762913_2764617_-\|amidohydrolase-family-protein	gnl\|CDD\|238625	cd01300, YtcJ_like, YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.	2.26769e-148
NZ_CP040750.1\|WP_064294172.1\|2759974_2760193_+\|hypothetical-protein	gnl\|CDD\|378012	pfam08496, Peptidase_S49_N, Peptidase family S49 N-terminal. This domain is found to the N-terminus of bacterial signal peptidases of the S49 family (pfam01343).	0.00799664
NZ_CP040750.1\|WP_138946355.1\|2766243_2767497_-\|hypothetical-protein	gnl\|CDD\|215463	PLN02858, PLN02858, fructose-bisphosphate aldolase.	1.64531e-48
NZ_CP040750.1\|WP_138946354.1\|2765802_2766177_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	9.69031e-37
NZ_CP040750.1\|WP_079705049.1\|2774130_2775027_-\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	2.31836e-13
NZ_CP040750.1\|WP_138946351.1\|2760268_2761045_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	3.01001e-151
NZ_CP040750.1\|WP_138946362.1\|2780059_2780836_+\|hypothetical-protein	gnl\|CDD\|377939	pfam07905, PucR, Purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.	2.89078e-26
NZ_CP040750.1\|WP_064294181.1\|2771493_2772195_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	2.33712e-133
NZ_CP040750.1\|WP_064294182.1\|2772191_2772452_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl\|CDD\|235659	PRK05974, PRK05974, phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed.	1.14465e-25
NZ_CP040750.1\|WP_138947310.1\|2762018_2762897_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270225	cd01004, PBP2_MidA_like, Mimosine binding domain of ABC-type transporter MidA and similar proteins; the type 2 periplasmic binding protein fold. This subgroup includes the periplasmic binding component of ABC transporter involved in uptake of mimosine MidA and its similar proteins. This periplasmic binding domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.12138e-78
NZ_CP040750.1\|WP_138946361.1\|2776888_2778355_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	0
NZ_CP040750.1\|WP_138946352.1\|2761041_2762016_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.89095e-72
NZ_CP040750.1\|WP_138946358.1\|2770588_2771296_-\|FCD-domain-containing-protein	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	3.60433e-27

>NZ_CP040750.1|WP_138946356.1|2767493_2768381_-|NAD-binding-protein
MASTPQPAHTITFVGIGAIGLPMATQLAAAGHRVTGVDPFPAARERAAAAGISAVASITEAPQADTVVVMVATPDQLAELVTLALADTDPAGQTWIIMSTVGPASVVEQAARLEAAGAAVVDAPVTGGVARASTGELTMFVSGSPTAIAAATEPLAALGTARIVGEAIGDGQAIKVVNQHLCAVHIAAAAEALALASSLGLDPAAVLPLVESGAAASWMLSDRGPRMLQDTDAPVMSRVDIFVKDTGLVADAASAAGAATPVLDAARERFLAAAASGLGARDDSRVIETYQGPHA
>NZ_CP040750.1|WP_138946355.1|2766243_2767497_-|hypothetical-protein
MKTLILDDDPTGTQSASGVDVLLEWDADLIEEALGGADAVYLLTNTRAVSEADAVALLERTRTEAEEAGRRLGERVHVVLRGDSTLRGHVFPETAVFTGPASVIVFVPAFPEGGRTTIDGTHYVRIGDETLPAHETEYAQDPVFPFRSGHLPDYVREQSGRETAHFGLAGLRDGAAEFRAALREAVPGTVLLPDAETGDDVRIIAQAITAAWADGADVVVRSASPLAAAIAGVESDGLLPSPLVAEPVAALLVCGSHTIGATRQLAPVEAAFGPAEIVPTSDALQDAVATGRAAAEAARARLTATGFAAISSERERDASHNTLDHGERVMIALTSATAVLRRSVEVVVSKGGITSAEVARVGLGARRARVLGQVLPGVSVWSVVTPEDEEKLYVVVPGNVGDPSTLVDVLAALGRTA
>NZ_CP040750.1|WP_138946354.1|2765802_2766177_+|helix-turn-helix-transcriptional-regulator
MTSVDTQLGRRPGFTDGVLPAACPSRTVLDHVTSKWGVLVLLALSDGTHRWGELRRVVQGISEKMLAQTLRTLEEDGLVVRVAHPEIPPRVEYSLSDRGRDLNEHLMPLMAWIDHNASEILGRA
>NZ_CP040750.1|WP_138946353.1|2762913_2764617_-|amidohydrolase-family-protein
MTSNADTVFTGGTVFRNALLTPQSGAVAVADGRIVALDADAYAAIDPDTEIVDLRGGLLLPGFVDAHVHPVEAGLEQLACDLSAERTPEGYLATIAAYAETHPERPWIVGGGWQQAAFPGGTPLAADLDRVVPDRPVFLQNRDHHGAWVNTAALRLAGIDHATPDPADGRIERDANGTPNGMLHEGARSLVSRFVPVDTDEDVAAALGAAQRTLHSFGVTGWQDAIVGDYGSHTDTSDAYLQAMADGSLTSDVVGALWWDRDRGLEQIDDLVARRDAIARHAAALGTTTGRFTAGTVKIMQDGIPENRTAAMIDPYLRTCHCGDTAPEHGISFLEPAILIEAVTRLDAAGFQVHFHAIGDRAVRECLDALEAARERNGESDNRHHIAHVQIVHPDDLPRFARLGVTMNMQALWATWEPQMLELNLPLLGDERASWQYPFGDAARLGTLLCAGSDWPVTTPDPWQALHVAVNRTLPADDPDHHPEPLNPGQSLTLGAAIAAYTRGSNRIDHRDDTGVIEVGAVADLVLVDRDPFAGPTSEIAHTRTVGTWIAGRRVFTSTTTSTEQGT
>NZ_CP040750.1|WP_138947310.1|2762018_2762897_-|transporter-substrate-binding-domain-containing-protein
MLPAALTAAAALLLTGCVNNEVATPDATGSAPAVTVDKAAEALLPDDIRQAGKLILGTDATYAPNEFKDANGDPIGWEIELADAMAGKLGLTTDYQVAKFDNIIPSITGGKYDVGLSSFFDTKERQQQVDMVDYFTAGIQWATLAGKSVDPDNSCGLKVAVQNGTTEALDDVPAKSQACTDAGKPAIEALGYDTQDEATAAVTLGRADAMTADSPVVQYAVQQSDGKLELSGDVYSTFLYGMPIAKDRGDLGKALQAALQSLMDDGTYGSILSKWGVESGAIDKIDINGATS
>NZ_CP040750.1|WP_138946352.1|2761041_2762016_-|ABC-transporter-permease-subunit
MSDSRTTGTASTPPVPLKVVKLRHPWRNVFAVIIVLLLVAFVVDAATRPAYDWPAVGKYVFDRRITMAALITLQLTVYSMIGAIVLGVVLAIMRLSPNPVLKAIAWGFVWLFRGTPVYVQLVFWGLLATIYPTLNIGLPFLPPIAQLPTDAALNTFWIAVIGLALNEAAYMSEIVRAGLLSVDRGQEEASTALGMSWAQTMRRVILPQSMRIIIPPTGNEVISMLKTTSLVTAVPFTQELYTRSRDISSETFNPIPLLIVASLWYLLFTSILMVGQYFLEKRFARGLTRIDAGAPVTTEAIQVQEAEAARAKQSPVDGESGERR
>NZ_CP040750.1|WP_138946351.1|2760268_2761045_-|ATP-binding-cassette-domain-containing-protein
MTNTDTTDMVRAEGVVKSFGSNTVLKDISLTVRRGEVMCLVGPSGSGKSTFLRCINHLERVDGGRLLVEGDLIGYRERGDKLYELKPKEAAKQRRDIGMVFQRFNLFPHMTALENIIEAPMQVKGQRRVVAEQRGRELLDRVGLSDKAAAYPGHLSGGQQQRVAIARALAMDPKLMLFDEPTSALDPELVGEVLDVMKGLAKDGMTMIVVTHEMGFAREVADSLVFMDGGVVVETGAPREVLADPQHARTRAFLSKVL
>NZ_CP040750.1|WP_064294172.1|2759974_2760193_+|hypothetical-protein
MGKKILLIIVGLIAFGAYTLGAKAGRTRYREIKHAAEEFWNDPRVEKARKKAVKNAKKATAKAQKEVQKKLH
>NZ_CP040750.1|WP_138946350.1|2759211_2759823_+|hypothetical-protein
MNSTNRGLNRLLILFIGLVLVVIGAAALAVVTVPVVADWWRDNRAAVLDTIDGWFAWNPFGADAGQTAPLLVPIVGIVLLVLVAALLISFILRQGRGRSGVVHRATVEHGDIVLETDVAANALGDALDDTEAFSSVRVSAWDVKRSQALKVAVTCRRGVSPRTAVETVSTAVESLDRLLGVELPVLVEVDGGLRAAKPKRVLQ
>NZ_CP040750.1|WP_138946349.1|2758606_2759215_+|hypothetical-protein
MTATAATTPVAGPTRVLRRLARRELHSPRSTAAILLAVLLVLVALWIAVETVLALIGLRPLLVAPGEIPAAAASLPTTQPVILGVAGALVLLLGVILIGIALGPGRRHRHLLSTGRVLAVVDDEVIASALAQRASTTAATHPDGTSVAVGRRTAAIRITPASGMPVDRSEVDRAVAADLDAFGLQPSLRATTSISSNGKVGQ
>NZ_CP040750.1|WP_168223398.1|2769041_2770316_-|DUF222-domain-containing-protein
MTETTAAAAVRAGDEYAAQLAEFSDRYADIQRRRAALDAEEARLLARSAAYADAFADATVPAIFPPAERLALSRRSTCAALAMATRTPEQTVQRATNDAERLVNDAPAVLASLEAGRISARHAQTIIDQLSDVPVEGRSAFLAEVLTVAEESTNANLRRRARVLRERLHPESITARAVRSEADRRVEFEPAADGMAWVHLFTTAPIAQGIIERVEAAAAESRAAGETRTCAQLQADALAALALTGVTPDDVMTRPVLAHPIEVQEHIKPTVQITVPALSMAGVSDAPATLDGYGPIDPETAARIAVNAPSFTRILVQPETGAVLSVGRNQYRVPADLQRAVRLRDGTCRAPGCGRRARACDLDHSIAWEDGGTTDVGNLACLCRHHHRLKHLPGWNLDHGPGGVLDWTTPDGKHHRTEPDPAPF
>NZ_CP040750.1|WP_138946358.1|2770588_2771296_-|FCD-domain-containing-protein
MAEPLEALVARLVELATPEPGTTARRLPPERELGEALQMSRGALREQLAVLERLGFLHRTQGRGTSIDAPGNDFVRSWFTISRQLGYLSDDQFARSRMMLEETVAEAAAGLVTDEAVAVLRDDVDRMIAATLAGDHDAALEADVDFHSRLNAIVDDPIFRLMHEGFSHVLRETIRQRRLRAIEVEQPDERGVRRTDSVHYAVVDALAARDAEAARRAMRQHFEDWLQLDADDGAS
>NZ_CP040750.1|WP_064294181.1|2771493_2772195_-|phosphoribosylformylglycinamidine-synthase-subunit-PurQ
MTTRIGVITFPGSLDDRDAQRAVRMAGAEPVALWHGDHDLQGVDAVILPGGFSYGDYLRAGAIAAVSPIMTELKDAAGKGMPILGICNGFQMLVEAHLLPGGLIRNAHQQFIRRDQLLTVENADTAWTHQFSKGQEITIPLKNADGGYIADAETLARVEGEGLVAFRYAGVNPNGSLDDIAGLTNPAGNVVGLMPHPEHAIEPGFGPDTPLAMRSGVDGLAFFTSAVQALQAV
>NZ_CP040750.1|WP_064294182.1|2772191_2772452_-|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MPTIVVEVMPKAELLDPQGKAVAGALARLGKSEFTDVRIGKRFELTVDGPITDATRATVQQIADDILSNAVIEDVVAIHYPEGSEA
>NZ_CP040750.1|WP_138946359.1|2772556_2774134_-|amino-acid-permease
MTPPETTPPRDIAHPETTATGALSKKGLGAGTVGLVGAIVIGISCIAPAYTLTGALGPTVAEVGTHVPAIFLVGFIPMLLVAFGYRELNSRMPDSGTSFTWATRAFGPWVGWMAGWGLIAATIVVLSNLAGIAVDFFYLMLSQIFQNPDIAGLTSNPFINVITCLAFMLGATLISYRDMQTTQKLQYVLVGFQLLVMVLFGIVAFAHVAGGDAFDALPISLDWFNPFAVGSFSAFAAGLSLSIFIFWGWDVTLTMSEETKGSSSTPGKAATATVVIIVVLYLFLSVALINYAGVGDGEFGLGNEDIQGNVFFSLAGPILGPLAILVSIAVLSSSAASLQSTFVSPARTLLAMGHYGALSPKFSKVHPKFFTPGYATIVSSVVASVFYAVMRFISEDVLWDTITTLGMMICFYYGLTAFACVWYFRKQWFSSARNFFFQFFSPLVGGLILGVLFFTTIIESADPSYGSGSNIGGVGLVFILGMIIIVAGIVIMLIQAKLRPDFFRNKTLARGIAGDANEADAALPE
>NZ_CP040750.1|WP_079705049.1|2774130_2775027_-|universal-stress-protein
MRYIVGYTDTPAGRDALALGIRIARTTGARLDIVLVLANEERPTITPADPGYERFLRETADRWLAEALDAVPADITAKTHLVYDESFAEGLLEASRILEGGLIIIGAARGGLLGRFTLGSVANTLLHSAVVPVALAPVGSRDLLDAQPTGGTVSRITCAIGTRAGAHQLLDAAIVVAKNAVIPLRLVSLVALDQPEGAEHPEATARAESHAAEVLAYATEHLPKDIDVTTEIASGTRIEDAVSHLEWKPAEIVLVGSSRLATPKHLFLGSTAAKMLRELPVPMVVVPRDSVLTLGDPT
>NZ_CP040750.1|WP_138946360.1|2775246_2776605_-|FAD-dependent-oxidoreductase
MSAIERDVVIIGAGASGLTAATKLRAAGLSVAVLEARDRVGGRLWTNHIDGAMLELGGQWVSPDQTALLATLEELGLDTYSRYREGDSVYVNAEGVRTRFTGDIFPVAESTAAEMERLITLLDELVEQVGVTEPWAHARAKEYDRISWSAWLAEQTDDVEARDNIALFIAAAMLTKPSHSFSLLQALLMAASAGSFTHLVEADFILDKRVVGGLQQVPIKLAEALGDDVHLSSPVRRLEWSDAGVSAEADSVTVNARYAIVAVPPNLYSRIDFQPPLPRLSHQMHQHMSLGLVIKVHAVYETPFWREDGLSATAFSPYELVHEAYDNTNHEDPRGTLVGFVSDERADEVFKLSAEERRERILTSLSHYYGEQALSPVVYYESDWGSEEWTRGAYAASFDLGGLSRYGAMQSTPVGPIFWSTSDLAAEGYQHVDGAIRKGADTAEAIIARHQA
>NZ_CP040750.1|WP_138946361.1|2776888_2778355_-|aldehyde-dehydrogenase-family-protein
MTDARETDLLAKVPNGLFIGGVWRDASEGATLDVSDPSTGDVIKTIADASVADGTAALDAAVAAQDEWAATAPRTRSNILRKAFDLLQERREEFALLMTLEMGKPLAEANGEVTYGGEFLRWFSEEAVRISGRYGSNPEGTGMMTVSQHPVGPCFLITPWNFPLAMATRKIAPALAAGCTVVVKPAELTPLTTLYFVKLLEDAGLPAGVVNVITTSSSSAVSGPIIADPRLRKLSFTGSTAVGQKLIEQSAKNVLRTSMELGGNAPFVVFEDADLDKAVEGAMAAKFRNIGQACTAANRFIVHRDVADEFAKRVTDKVNAFRIGRGTEDGVTIGPLIDDRAVTKAKTLVGDAVERGAEVLTGGEAVDGPGTFFQPTVVTGVVPGSDILREEIFGPVLAIVPFDDEDEAVRLANDTEYGLVSYVFTTDLARGQRMIGRLQTGMMGLNVGVISNAAAPFGGVKQSGIGREGGLEGIHEYLYTKYTMTPIG
>NZ_CP040750.1|WP_138946362.1|2780059_2780836_+|hypothetical-protein
MAPTLQDLLDHRALGLKLVVAGSEGALDRQVAWVSGSDLPDPTPFLLADQVLLTTGTQFGTAVSTTQVEAYVARLADAGVAGLGFGTEVITAGTPPELAEACAAHGMPLIEVPYRTPFIAVIRYAADLLTEAARARDAWALGAQRAIAFAALRPDATVAVVTELARSLGAWVVLFDAHATPVAISGDGPTAGPETERLLERVAGEATMLLSRGQRSGATLASRTRTVSLQTLGRRGDLRGVLAIAGTDGPWTPRPKAS
>NZ_CP040750.1|WP_138946363.1|2780832_2781654_+|hypothetical-protein
MTSVVAIAGLTLEQGGALGRAGRSLRTGVWQLLRAGQTTAAREVAEQLGTPLPTGAVRVGVCSGPTEGREALLTELERAETLSPGSLFVAEQDGRPVLLLAAAEGDTETDVDRAVEAVIAAAPARRLGLSRAVALAELTTGIDQAVSAHEQAVSAGEAVVRFGALAAAGMAGLLDPVRAAAVAEELLEPVLRVDREEGSDLVPSLRGWLEANGQWESAARRLGVHRHTLRNRITRVEQVLGRPLDTFAARAEVWLALVSLPDGDALRSRAAVL

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Crispr_ID: NZ_CP040750_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_19

2776637-2776755

Orphan

Consensus_repeat	Method
TGCTCGGGGGCCGGGGTGGTGCTGTCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_19

>merge|NZ_CP040750|19|2776637-2776755|CRISPRCasFinder
AGCTCAGGGACCGGGGTGATGCTCGGGGGCCGGGGTGGTGCTGTCGGTACCGGGTGGTGCTCGGGGACCGGGTGGTGGTGCTGTCGGGTGGTGCTCGCGGGCCGGGGTGGTGCTGTCGG

>NZ_CP040750|19|17|2776637-2776755|CRISPRCasFinder
AGCTCAGGGACCGGGGTGATGCTCGGGG	GCCGGGGTGGTGCTGTCGGTACCGGGTGGTGCTCGGGGACCGGGTGGTGGTGCTGTCGGGTGG
TGCTCGCGGGCCGGGGTGGTGCTGTCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138946363.1\|2780832_2781654_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379258
NZ_CP040750.1\|WP_138947312.1\|2790450_2791698_+\|TIGR03364-family-FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|132407
NZ_CP040750.1\|WP_138946359.1\|2772556_2774134_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP040750.1\|WP_168223398.1\|2769041_2770316_-\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP040750.1\|WP_138947311.1\|2785262_2786399_-\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|369561
NZ_CP040750.1\|WP_138946365.1\|2783774_2785205_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223092
NZ_CP040750.1\|WP_138946356.1\|2767493_2768381_-\|NAD-binding-protein	unknown	unknown	gnl\|CDD\|224995
NZ_CP040750.1\|WP_138946360.1\|2775246_2776605_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366721
NZ_CP040750.1\|WP_138946355.1\|2766243_2767497_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215463
NZ_CP040750.1\|WP_138946354.1\|2765802_2766177_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP040750.1\|WP_079705049.1\|2774130_2775027_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NZ_CP040750.1\|WP_138946358.1\|2770588_2771296_-\|FCD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225097
NZ_CP040750.1\|WP_138946362.1\|2780059_2780836_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377939
NZ_CP040750.1\|WP_064294181.1\|2771493_2772195_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	unknown	unknown	gnl\|CDD\|235140
NZ_CP040750.1\|WP_138946364.1\|2781708_2783760_+\|DUF2156-domain-containing-protein	unknown	unknown	gnl\|CDD\|378310
NZ_CP040750.1\|WP_138946366.1\|2786669_2787590_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270232
NZ_CP040750.1\|WP_138946361.1\|2776888_2778355_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143421
NZ_CP040750.1\|WP_064294182.1\|2772191_2772452_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl\|CDD\|235659
NZ_CP040750.1\|WP_138946367.1\|2787687_2788683_+\|phosphonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213223
NZ_CP040750.1\|WP_138947313.1\|2791667_2792495_+\|HAD-hydrolase-like-protein	unknown	unknown	gnl\|CDD\|274534

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138946363.1\|2780832_2781654_+\|hypothetical-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	2.72137e-15
NZ_CP040750.1\|WP_138947312.1\|2790450_2791698_+\|TIGR03364-family-FAD-dependent-oxidoreductase	gnl\|CDD\|132407	TIGR03364, putative_secreted_oxidoreductase, FAD dependent oxidoreductase TIGR03364. This clade of FAD dependent oxidoreductases (members of the pfam01266 family) is syntenically associated with a family of proposed phosphonatase-like enzymes (TIGR03351) and is also found (less frequently) in association with phosphonate transporter components. A likely role for this enzyme involves the oxidative deamination of an aminophosphonate differring slightly from 2-aminoethylphosphonate, possibly 1-hydroxy-2-aminoethylphosphonate (see the comments for TIGR03351). Many members of the larger FAD dependent oxidoreductase family act as amino acid oxidative deaminases.	3.91862e-115
NZ_CP040750.1\|WP_138946359.1\|2772556_2774134_-\|amino-acid-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.47108e-29
NZ_CP040750.1\|WP_168223398.1\|2769041_2770316_-\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	4.53107e-17
NZ_CP040750.1\|WP_138947311.1\|2785262_2786399_-\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	5.84554e-47
NZ_CP040750.1\|WP_138946365.1\|2783774_2785205_-\|hypothetical-protein	gnl\|CDD\|223092	COG0013, AlaS, Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].	4.88153e-148
NZ_CP040750.1\|WP_138946356.1\|2767493_2768381_-\|NAD-binding-protein	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	6.90976e-61
NZ_CP040750.1\|WP_138946360.1\|2775246_2776605_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	2.29337e-79
NZ_CP040750.1\|WP_138946355.1\|2766243_2767497_-\|hypothetical-protein	gnl\|CDD\|215463	PLN02858, PLN02858, fructose-bisphosphate aldolase.	1.64531e-48
NZ_CP040750.1\|WP_138946354.1\|2765802_2766177_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	9.69031e-37
NZ_CP040750.1\|WP_079705049.1\|2774130_2775027_-\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	2.31836e-13
NZ_CP040750.1\|WP_138946358.1\|2770588_2771296_-\|FCD-domain-containing-protein	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	3.60433e-27
NZ_CP040750.1\|WP_138946362.1\|2780059_2780836_+\|hypothetical-protein	gnl\|CDD\|377939	pfam07905, PucR, Purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.	2.89078e-26
NZ_CP040750.1\|WP_064294181.1\|2771493_2772195_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	2.33712e-133
NZ_CP040750.1\|WP_138946364.1\|2781708_2783760_+\|DUF2156-domain-containing-protein	gnl\|CDD\|378310	pfam09924, DUF2156, Uncharacterized conserved protein (DUF2156). This domain, found in various hypothetical prokaryotic proteins, has no known function.	8.38252e-66
NZ_CP040750.1\|WP_138946366.1\|2786669_2787590_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270232	cd01071, PBP2_PhnD_like, Substrate binding domain of phosphonate uptake system-like, a member of the type 2 periplasmic-binding fold superfamily. This family includes alkylphosphonate binding domain PhnD. These domains are found in PhnD-like proteins that are predicted to function as initial receptors in hypophosphite, phosphonate, or phosphate ABC transport in archaea and eubacteria. PhnD is the periplasmic binding component of an ABC-type phosphonate uptake system (PhnCDE) that recognizes and binds phosphonate. PhnD belongs to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. The PBP2 have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.55149e-60
NZ_CP040750.1\|WP_138946361.1\|2776888_2778355_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	0
NZ_CP040750.1\|WP_064294182.1\|2772191_2772452_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl\|CDD\|235659	PRK05974, PRK05974, phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed.	1.14465e-25
NZ_CP040750.1\|WP_138946367.1\|2787687_2788683_+\|phosphonate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213223	cd03256, ABC_PhnC_transporter, ATP-binding cassette domain of the binding protein-dependent phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	3.71402e-105
NZ_CP040750.1\|WP_138947313.1\|2791667_2792495_+\|HAD-hydrolase-like-protein	gnl\|CDD\|274534	TIGR03351, PhnX-like, phosphonatase-like hydrolase. This clade of sequences are the closest homologs to the PhnX enzyme, phosphonoacetaldehyde (Pald) hydrolase (phosphonatase, TIGR01422). This phosphonatase-like enzyme and PhnX itself are members of the haloacid dehalogenase (HAD) superfamily (pfam00702) having a a number of distinctive features that set them apart from typical HAD enzymes. The typical HAD N-terminal motif DxDx(T/V) here is DxAGT and the usual conserved lysine prior to the C-terminal motif is instead an arginine. Also distinctive of phosphonatase, and particular to its bi-catalytic mechanism is a conserved lysine in the variable "cap" domain. This lysine forms a Schiff base with the aldehyde of phosphonoacetaldehyde, providing, through the resulting positive charge, a polarization of the C-P bond necesary for cleavage as well as a route to the initial product of cleavage, an ene-amine. The conservation of these elements in this phosphonatase-like enzyme suggests that the substrate is also, like Pald, a 2-oxo-ethylphosphonate. Despite this, the genomic context of members of this family are quite distinct from PhnX, which is almost invariably associated with the 2-aminoethylphosphonate transaminase PhnW (TIGR02326), the source of the substrate Pald. Members of this clade are never associated with PhnW, but rather associate with families of FAD-dependent oxidoreductases related to deaminating amino acid oxidases (pfam01266) as well as zinc-dependent dehydrogenases (pfam00107). Notably, family members from Arthrobacter aurescens TC1 and Nocardia farcinica IFM 10152 are adjacent to the PhnCDE ABC cassette phosphonates transporter (GenProp0236) typically found in association with the phosphonates C-P lyase system (GenProp0232). These observations suggest two possibilities. First, the substrate for this enzyme family is also Pald, the non-association with PhnW not withstanding. Alternatively, the substrate is something very closely related such as hydroxyphosphonoacetaldehyde (Hpald). Hpald could come from oxidative deamination of 1-hydroxy-2-aminoethylphosphonate (HAEP) by the associated oxidase. HAEP would not be a substrate for PhnW due to its high specificity for AEP. HAEP has been shown to be a constituent of the sphingophosphonolipid of Bacteriovorax stolpii, and presumably has other natural sources. If Hpald is the substrate, the product would be glycoaldehyde (hydroxyacetaldehyde), and the associated alcohol dehydrogenase may serve to convert this to glycol.	2.06772e-56

>NZ_CP040750.1|WP_138946360.1|2775246_2776605_-|FAD-dependent-oxidoreductase
MSAIERDVVIIGAGASGLTAATKLRAAGLSVAVLEARDRVGGRLWTNHIDGAMLELGGQWVSPDQTALLATLEELGLDTYSRYREGDSVYVNAEGVRTRFTGDIFPVAESTAAEMERLITLLDELVEQVGVTEPWAHARAKEYDRISWSAWLAEQTDDVEARDNIALFIAAAMLTKPSHSFSLLQALLMAASAGSFTHLVEADFILDKRVVGGLQQVPIKLAEALGDDVHLSSPVRRLEWSDAGVSAEADSVTVNARYAIVAVPPNLYSRIDFQPPLPRLSHQMHQHMSLGLVIKVHAVYETPFWREDGLSATAFSPYELVHEAYDNTNHEDPRGTLVGFVSDERADEVFKLSAEERRERILTSLSHYYGEQALSPVVYYESDWGSEEWTRGAYAASFDLGGLSRYGAMQSTPVGPIFWSTSDLAAEGYQHVDGAIRKGADTAEAIIARHQA
>NZ_CP040750.1|WP_079705049.1|2774130_2775027_-|universal-stress-protein
MRYIVGYTDTPAGRDALALGIRIARTTGARLDIVLVLANEERPTITPADPGYERFLRETADRWLAEALDAVPADITAKTHLVYDESFAEGLLEASRILEGGLIIIGAARGGLLGRFTLGSVANTLLHSAVVPVALAPVGSRDLLDAQPTGGTVSRITCAIGTRAGAHQLLDAAIVVAKNAVIPLRLVSLVALDQPEGAEHPEATARAESHAAEVLAYATEHLPKDIDVTTEIASGTRIEDAVSHLEWKPAEIVLVGSSRLATPKHLFLGSTAAKMLRELPVPMVVVPRDSVLTLGDPT
>NZ_CP040750.1|WP_138946359.1|2772556_2774134_-|amino-acid-permease
MTPPETTPPRDIAHPETTATGALSKKGLGAGTVGLVGAIVIGISCIAPAYTLTGALGPTVAEVGTHVPAIFLVGFIPMLLVAFGYRELNSRMPDSGTSFTWATRAFGPWVGWMAGWGLIAATIVVLSNLAGIAVDFFYLMLSQIFQNPDIAGLTSNPFINVITCLAFMLGATLISYRDMQTTQKLQYVLVGFQLLVMVLFGIVAFAHVAGGDAFDALPISLDWFNPFAVGSFSAFAAGLSLSIFIFWGWDVTLTMSEETKGSSSTPGKAATATVVIIVVLYLFLSVALINYAGVGDGEFGLGNEDIQGNVFFSLAGPILGPLAILVSIAVLSSSAASLQSTFVSPARTLLAMGHYGALSPKFSKVHPKFFTPGYATIVSSVVASVFYAVMRFISEDVLWDTITTLGMMICFYYGLTAFACVWYFRKQWFSSARNFFFQFFSPLVGGLILGVLFFTTIIESADPSYGSGSNIGGVGLVFILGMIIIVAGIVIMLIQAKLRPDFFRNKTLARGIAGDANEADAALPE
>NZ_CP040750.1|WP_064294182.1|2772191_2772452_-|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MPTIVVEVMPKAELLDPQGKAVAGALARLGKSEFTDVRIGKRFELTVDGPITDATRATVQQIADDILSNAVIEDVVAIHYPEGSEA
>NZ_CP040750.1|WP_064294181.1|2771493_2772195_-|phosphoribosylformylglycinamidine-synthase-subunit-PurQ
MTTRIGVITFPGSLDDRDAQRAVRMAGAEPVALWHGDHDLQGVDAVILPGGFSYGDYLRAGAIAAVSPIMTELKDAAGKGMPILGICNGFQMLVEAHLLPGGLIRNAHQQFIRRDQLLTVENADTAWTHQFSKGQEITIPLKNADGGYIADAETLARVEGEGLVAFRYAGVNPNGSLDDIAGLTNPAGNVVGLMPHPEHAIEPGFGPDTPLAMRSGVDGLAFFTSAVQALQAV
>NZ_CP040750.1|WP_138946358.1|2770588_2771296_-|FCD-domain-containing-protein
MAEPLEALVARLVELATPEPGTTARRLPPERELGEALQMSRGALREQLAVLERLGFLHRTQGRGTSIDAPGNDFVRSWFTISRQLGYLSDDQFARSRMMLEETVAEAAAGLVTDEAVAVLRDDVDRMIAATLAGDHDAALEADVDFHSRLNAIVDDPIFRLMHEGFSHVLRETIRQRRLRAIEVEQPDERGVRRTDSVHYAVVDALAARDAEAARRAMRQHFEDWLQLDADDGAS
>NZ_CP040750.1|WP_168223398.1|2769041_2770316_-|DUF222-domain-containing-protein
MTETTAAAAVRAGDEYAAQLAEFSDRYADIQRRRAALDAEEARLLARSAAYADAFADATVPAIFPPAERLALSRRSTCAALAMATRTPEQTVQRATNDAERLVNDAPAVLASLEAGRISARHAQTIIDQLSDVPVEGRSAFLAEVLTVAEESTNANLRRRARVLRERLHPESITARAVRSEADRRVEFEPAADGMAWVHLFTTAPIAQGIIERVEAAAAESRAAGETRTCAQLQADALAALALTGVTPDDVMTRPVLAHPIEVQEHIKPTVQITVPALSMAGVSDAPATLDGYGPIDPETAARIAVNAPSFTRILVQPETGAVLSVGRNQYRVPADLQRAVRLRDGTCRAPGCGRRARACDLDHSIAWEDGGTTDVGNLACLCRHHHRLKHLPGWNLDHGPGGVLDWTTPDGKHHRTEPDPAPF
>NZ_CP040750.1|WP_138946356.1|2767493_2768381_-|NAD-binding-protein
MASTPQPAHTITFVGIGAIGLPMATQLAAAGHRVTGVDPFPAARERAAAAGISAVASITEAPQADTVVVMVATPDQLAELVTLALADTDPAGQTWIIMSTVGPASVVEQAARLEAAGAAVVDAPVTGGVARASTGELTMFVSGSPTAIAAATEPLAALGTARIVGEAIGDGQAIKVVNQHLCAVHIAAAAEALALASSLGLDPAAVLPLVESGAAASWMLSDRGPRMLQDTDAPVMSRVDIFVKDTGLVADAASAAGAATPVLDAARERFLAAAASGLGARDDSRVIETYQGPHA
>NZ_CP040750.1|WP_138946355.1|2766243_2767497_-|hypothetical-protein
MKTLILDDDPTGTQSASGVDVLLEWDADLIEEALGGADAVYLLTNTRAVSEADAVALLERTRTEAEEAGRRLGERVHVVLRGDSTLRGHVFPETAVFTGPASVIVFVPAFPEGGRTTIDGTHYVRIGDETLPAHETEYAQDPVFPFRSGHLPDYVREQSGRETAHFGLAGLRDGAAEFRAALREAVPGTVLLPDAETGDDVRIIAQAITAAWADGADVVVRSASPLAAAIAGVESDGLLPSPLVAEPVAALLVCGSHTIGATRQLAPVEAAFGPAEIVPTSDALQDAVATGRAAAEAARARLTATGFAAISSERERDASHNTLDHGERVMIALTSATAVLRRSVEVVVSKGGITSAEVARVGLGARRARVLGQVLPGVSVWSVVTPEDEEKLYVVVPGNVGDPSTLVDVLAALGRTA
>NZ_CP040750.1|WP_138946354.1|2765802_2766177_+|helix-turn-helix-transcriptional-regulator
MTSVDTQLGRRPGFTDGVLPAACPSRTVLDHVTSKWGVLVLLALSDGTHRWGELRRVVQGISEKMLAQTLRTLEEDGLVVRVAHPEIPPRVEYSLSDRGRDLNEHLMPLMAWIDHNASEILGRA
>NZ_CP040750.1|WP_138946361.1|2776888_2778355_-|aldehyde-dehydrogenase-family-protein
MTDARETDLLAKVPNGLFIGGVWRDASEGATLDVSDPSTGDVIKTIADASVADGTAALDAAVAAQDEWAATAPRTRSNILRKAFDLLQERREEFALLMTLEMGKPLAEANGEVTYGGEFLRWFSEEAVRISGRYGSNPEGTGMMTVSQHPVGPCFLITPWNFPLAMATRKIAPALAAGCTVVVKPAELTPLTTLYFVKLLEDAGLPAGVVNVITTSSSSAVSGPIIADPRLRKLSFTGSTAVGQKLIEQSAKNVLRTSMELGGNAPFVVFEDADLDKAVEGAMAAKFRNIGQACTAANRFIVHRDVADEFAKRVTDKVNAFRIGRGTEDGVTIGPLIDDRAVTKAKTLVGDAVERGAEVLTGGEAVDGPGTFFQPTVVTGVVPGSDILREEIFGPVLAIVPFDDEDEAVRLANDTEYGLVSYVFTTDLARGQRMIGRLQTGMMGLNVGVISNAAAPFGGVKQSGIGREGGLEGIHEYLYTKYTMTPIG
>NZ_CP040750.1|WP_138946362.1|2780059_2780836_+|hypothetical-protein
MAPTLQDLLDHRALGLKLVVAGSEGALDRQVAWVSGSDLPDPTPFLLADQVLLTTGTQFGTAVSTTQVEAYVARLADAGVAGLGFGTEVITAGTPPELAEACAAHGMPLIEVPYRTPFIAVIRYAADLLTEAARARDAWALGAQRAIAFAALRPDATVAVVTELARSLGAWVVLFDAHATPVAISGDGPTAGPETERLLERVAGEATMLLSRGQRSGATLASRTRTVSLQTLGRRGDLRGVLAIAGTDGPWTPRPKAS
>NZ_CP040750.1|WP_138946363.1|2780832_2781654_+|hypothetical-protein
MTSVVAIAGLTLEQGGALGRAGRSLRTGVWQLLRAGQTTAAREVAEQLGTPLPTGAVRVGVCSGPTEGREALLTELERAETLSPGSLFVAEQDGRPVLLLAAAEGDTETDVDRAVEAVIAAAPARRLGLSRAVALAELTTGIDQAVSAHEQAVSAGEAVVRFGALAAAGMAGLLDPVRAAAVAEELLEPVLRVDREEGSDLVPSLRGWLEANGQWESAARRLGVHRHTLRNRITRVEQVLGRPLDTFAARAEVWLALVSLPDGDALRSRAAVL
>NZ_CP040750.1|WP_138946364.1|2781708_2783760_+|DUF2156-domain-containing-protein
MRIRTVVARVPVTIALVLIVLVVGVVGRGLWESTTAQPWWDAVAYGLPAFEAGRWWTPVTGTFLVVEPWAYVFAVVGFAWVGLLEWWRGSKVALITFAAGQLVAVLATAGFLWAASQLPWPWATSLAGMLDVGPSGGTMACFAACVSLFASPWRQRGWIIVASYAAIGVLFIGSLADLEHAFAVLFVLAVNRSFRIQRASIRERRLLAFTTSVALGVVQIVALLVPTNGPFGPTAPAEGPWLDVAIDTVVIILVANGLRLGRRWAWVLSVVWAILNVLVAVLYLALSPLDPADLPIDWGDTDVFLATSVLWLAFLVYLLATRSAFSSHRRRQLGVGRKQQQDLPSSDDARALIRTDGGGSLSWMATWDGMEYFRTSVGLVPYQKHAGVAIVLADPLGPPEHLQASVEEFVQAAERDSLIPCFFSSSKPTKDAMPDGWRDLIIADDTIVDLPGLAFTGKAWSNIRTALNKAEREGMVFRMSTYAAETWGVRQQIRAISEGWVGDKGLPEMRFTLGTLQEADDQEVRLALAISPDGDVDGFLSWLPVFGPDGEHRGWTLDLMRRREEGFGSVMEFLIASSAKVFAEEGAQILSLSGAPLAHRVEDDEGRIAHLLGQLSGILEPVYGFSSLHRFKQKFNPRSEPIYLLYRDEGDLTRIAAALTRAFLPDATLRQFAGAGIDMLKRD
>NZ_CP040750.1|WP_138946365.1|2783774_2785205_-|hypothetical-protein
MDAHEIRNAYLDFLERNGHALIKRAPLVPRGDTSTLFNGSGMQALLPYLLGQDHPDGRRLTDSQPCVRAQDIEDVGDNRHTTFFEMLGNWSLGDYFKETQIRQFFAFLVDIVGLDPERISVTCFIGDPANGIPRDDEAASIWASVFAERGVSSGIAEIGSQADGDARGVRPGERIFFYDGGENWWSRGGSLEGTPIGDPCGPDSEVFYDFGPEFQDPSYGLAHPASDGGRFMEIGNQVFMQYRRREDGSFEELARRNVDFGGGLERIAAASIDSDDVFRISLLWPIVERLQELTGKRYEDETAAMRIIADHLRGATFLAVDGVRPSNKEQGYVMRRLLRRAIRLALSLDLHENFFGEIVPVIAGLYADDYPEVAAARDEVVAVLVKEEQSFRRTLGAGLQMVQGYAGRVMTGHDVFRLSDTNGFPKELTIEEAGRLGIEVVSDWETEFAAALAEQRARSRGATHLGAAGLPGGETA
>NZ_CP040750.1|WP_138947311.1|2785262_2786399_-|alpha/beta-hydrolase-fold-domain-containing-protein
MPLDPIFVERARTHRAYLISTALEQAKAFFLRPKTTTVARPKPAPAADPTATPSNATGPKAKPSSATAKATTATPRRKKTRAQHRKAARNWDKKELATVGVPGPELRIEEHTIPVAGFPDVRIRLYHPPTADGDQAVPAVLSFFGGAFRIGGIDYPTTDAGFRRRSADAGVVIAAVDYALAPEHRYPTQLEQAHAALEWLFAEAATLGVDAGRVAVAGVSAGGSIAAALTLVNRERGRLPIRLQLLEVPVTDLTGGHIDLRPVREMGIPRIFAIKELRSVAKTYLLDRRQAKEPHASPLLARSHADLPRAVILTAEYDPLRGDGAAYLAALRADGVDASGTMYLGATHDTPIFGGVLPAARRWHEDVVTALRSLHDAD
>NZ_CP040750.1|WP_138946366.1|2786669_2787590_+|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein
MKLSLTRVAALGAAVLLSIGLAACSSATASDTGSAAAGTFAVDDQTLVFGVVPDSVDTQTNYQPLMDYIAKETGKKVEYHESTDYAALIEAAVAGKIDVASFSGFTYVTALNNGAKITPISSIITDKGQEPGYYSEAIVPKDSSITKIEEFKGKKVCFVDPSSTSGYLFPSYNLLEAGIDPEKDITPVFAGKHDVSVTKTAEGVECEAGFAEDSEVEKNDGVKVIDRTMVPGAPIVESDSLPADVKEKLEKALSEVTIDQIIDSGVKSADSDAFRATFYGTSPVDDAYYDTIRDICKKTNAKQCQA
>NZ_CP040750.1|WP_138946367.1|2787687_2788683_+|phosphonate-ABC-transporter-ATP-binding-protein
MSVTEQQARRTAPDGAEPLVRLRGVTKRFDRTVALQRVDLDIRRGEIVVLLGLSGSGKSTLLRHLDGLERPTAGSVSVLGDEVPSLGQRALRRLRARVGFVFQQFELVPSLTVLENVLTGSLAGVRGPRLGIFGYGRTLKLRALGHLDRVGLLERAYQRADTLSGGQQQRVAIARALMQDPEILLADEPVASLDPESSEQVMALIREIAIDRGLTVVCSLHQVDLALSWGDRIVGLRHGEVVLDTTTDGLSKTEVMEIYGRVATSTRELQAIAVELESDELLGDPDDDLRGLLGVEERVGEDELPDDPEWEFDADVDGREPDELRRPGRTR
>NZ_CP040750.1|WP_138947312.1|2790450_2791698_+|TIGR03364-family-FAD-dependent-oxidoreductase
MSGGVSAPRVGLGVGSLGASADRADVVIVGAGIVGLSAALAAVDAGAEVVVVERSAEAQGASVRNFGHLAATPQAGLASRLAARSAEIWQRLEQDAGLWVRRSGTHVVARHLDELRVLEDFAASRAQAGAAADIRLYDAAEFLQQVPVSADDVVGGAWLPRDLQVNPRQALGAVTAYLERRGVEFRRRTTVTGLRSGFVDTSRGVIAAGLTVVAVNHDIDTLLPELAERAAVRRCALDMVRVRGELPMPMPAPLLTGWSLLRYGGFADSPAIPALRERLQQDHPGLASLDVNLMATQLPDGSIILGDTHSRGEAVSPFQSEHAFDELLRAGSTLFGTRLDVLERWQGVYATAPEELLIDEPTPGVRVVAATTGIGMTTGPALGELAVAEHLGPTFSPAQPPSIRAASAHLQKGLS
>NZ_CP040750.1|WP_138947313.1|2791667_2792495_+|HAD-hydrolase-like-protein
MSPPSERPLVTSIDRPQQDSTAAPDLDDDVETDLADLDELEDGFDDAHEDDLLLELVVLDLAGTTVSDDGVVEDAFRVAAETIGIDTEDALDAAIELVRDTMGQSKLDVFLMLTDGDEARAASGNAAFEEAYERLVGEGRVDAIPGAEDTVRRLRELGVGVVFTTGFAPATRDALLASLGWSELAEDALSPADAGRGRPAPDLPLTALLRFGASAVDTMVVVGDTASDMLSGVNAGAGLVVGVLTGAHDEETLLAAGADEIITSIAELPALLGLD

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Crispr_ID: NZ_CP040750_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_20

3252575-3252669

Orphan

Consensus_repeat	Method
TCCTCGTGGGCACTTCGACAGGCTCAGTGACCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_20

>merge|NZ_CP040750|20|3252575-3252669|CRISPRCasFinder
TCCTCGTGGGCACTTCGACAGGCTCAGTGACCGGAAGCGGTGTGCCCGGAACGATGAAGCGTCCTCGTGGGCACTTCGACAAGCTCAGTGACCGG

>NZ_CP040750|20|18|3252575-3252669|CRISPRCasFinder
TCCTCGTGGGCACTTCGACAGGCTCAGTGACCGG	AAGCGGTGTGCCCGGAACGATGAAGCG
TCCTCGTGGGCACTTCGACAAGCTCAGTGACCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_079705400.1\|3254266_3254947_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP040750.1\|WP_079001938.1\|3258176_3258428_-\|response-regulator	unknown	unknown	unknown
NZ_CP040750.1\|WP_138946609.1\|3254960_3256424_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|365860
NZ_CP040750.1\|WP_138946611.1\|3258453_3259437_-\|galactose-mutarotase	unknown	unknown	gnl\|CDD\|185699
NZ_CP040750.1\|WP_138946605.1\|3246959_3247613_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP040750.1\|WP_138946610.1\|3256653_3258114_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP040750.1\|WP_138946615.1\|3263732_3264923_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP040750.1\|WP_124768909.1\|3244313_3244760_-\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|376605
NZ_CP040750.1\|WP_138946612.1\|3259491_3261063_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|273327
NZ_CP040750.1\|WP_064296530.1\|3263426_3263705_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376835
NZ_CP040750.1\|WP_138946606.1\|3247697_3248723_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236545
NZ_CP040750.1\|WP_138946608.1\|3251271_3252543_+\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP040750.1\|WP_138946614.1\|3262065_3263343_-\|DUF445-family-protein	unknown	unknown	gnl\|CDD\|377281
NZ_CP040750.1\|WP_138946604.1\|3245191_3245791_-\|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl\|CDD\|274270
NZ_CP040750.1\|WP_138946613.1\|3260967_3262053_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370676
NZ_CP040750.1\|WP_137242059.1\|3248830_3249484_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP040750.1\|WP_138946602.1\|3244061_3244277_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_124768911.1\|3245944_3246838_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|133021
NZ_CP040750.1\|WP_138946603.1\|3244811_3245159_-\|FmdB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225210
NZ_CP040750.1\|WP_138946607.1\|3249759_3250935_+\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240658

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_079705400.1\|3254266_3254947_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	9.83798e-15
NZ_CP040750.1\|WP_138946615.1\|3263732_3264923_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	2.21921e-43
NZ_CP040750.1\|WP_138946611.1\|3258453_3259437_-\|galactose-mutarotase	gnl\|CDD\|185699	cd09022, Aldose_epim_Ec_YihR, Aldose 1-epimerase, similar to Escherichia coli YihR. Proteins similar to Escherichia coli YihR are uncharacterized members of aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	4.1606e-132
NZ_CP040750.1\|WP_138946605.1\|3246959_3247613_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	2.53187e-28
NZ_CP040750.1\|WP_138946609.1\|3254960_3256424_-\|MFS-transporter	gnl\|CDD\|365860	pfam00083, Sugar_tr, Sugar (and other) transporter.	7.16592e-38
NZ_CP040750.1\|WP_138946612.1\|3259491_3261063_-\|MFS-transporter	gnl\|CDD\|273327	TIGR00895, transport_protein, benzoate transport. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	4.30711e-70
NZ_CP040750.1\|WP_064296530.1\|3263426_3263705_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|376835	pfam02583, Trns_repr_metal, Metal-sensitive transcriptional repressor. This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression.	1.30231e-20
NZ_CP040750.1\|WP_138946606.1\|3247697_3248723_+\|hypothetical-protein	gnl\|CDD\|236545	PRK09510, tolA, cell envelope integrity inner membrane protein TolA; Provisional.	0.000124816
NZ_CP040750.1\|WP_138946608.1\|3251271_3252543_+\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	8.97743e-18
NZ_CP040750.1\|WP_138946614.1\|3262065_3263343_-\|DUF445-family-protein	gnl\|CDD\|377281	pfam04286, DUF445, Protein of unknown function (DUF445). Predicted to be a membrane protein.	7.68372e-128
NZ_CP040750.1\|WP_138946604.1\|3245191_3245791_-\|5-formyltetrahydrofolate-cyclo-ligase	gnl\|CDD\|274270	TIGR02727, Uncharacterized_protein_YqgN, 5,10-methenyltetrahydrofolate synthetase. This enzyme, 5,10-methenyltetrahydrofolate synthetase, is also called 5-formyltetrahydrofolate cycloligase. Function of bacterial proteins in this family was inferred originally from the known activity of eukaryotic homologs. Recently, activity was shown explicitly for the member from Mycoplasma pneumonia. Members of this family from alpha- and gamma-proteobacteria, designated ygfA, are often found in an operon with 6S structural RNA, and show a similar pattern of high expression during stationary phase. The function may be to deplete folate to slow 1-carbon biosynthetic metabolism. [Central intermediary metabolism, One-carbon metabolism].	5.01851e-48
NZ_CP040750.1\|WP_138946613.1\|3260967_3262053_+\|hypothetical-protein	gnl\|CDD\|370676	pfam09770, PAT1, Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.	3.63212e-13
NZ_CP040750.1\|WP_124768909.1\|3244313_3244760_-\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	2.10239e-46
NZ_CP040750.1\|WP_137242059.1\|3248830_3249484_+\|hypothetical-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	0.00971921
NZ_CP040750.1\|WP_138946610.1\|3256653_3258114_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.76573e-47
NZ_CP040750.1\|WP_124768911.1\|3245944_3246838_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|133021	cd02541, UGPase_prokaryotic, Prokaryotic UGPase catalyses the synthesis of UDP-glucose. Prokaryotic UDP-Glucose Pyrophosphorylase (UGPase) catalyzes a reversible production of UDP-Glucose and pyrophosphate (PPi) from glucose-1-phosphate and UTP. UDP-glucose plays pivotal roles in galactose utilization, in glycogen synthesis, and in the synthesis of the carbohydrate moieties of glycolipids , glycoproteins , and proteoglycans. UGPase is found in both prokaryotes and eukaryotes, although prokaryotic and eukaryotic forms of UGPase catalyze the same reaction, they share low sequence similarity.	3.49319e-146
NZ_CP040750.1\|WP_138946603.1\|3244811_3245159_-\|FmdB-family-transcriptional-regulator	gnl\|CDD\|225210	COG2331, COG2331, Uncharacterized protein conserved in bacteria [Function unknown].	1.80129e-27
NZ_CP040750.1\|WP_138946607.1\|3249759_3250935_+\|alanine-dehydrogenase	gnl\|CDD\|240658	cd12181, ceo_syn, N(5)-(carboxyethyl)ornithine synthase. N(5)-(carboxyethyl)ornithine synthase (ceo_syn) catalyzes the NADP-dependent conversion of N5-(L-1-carboxyethyl)-L-ornithine to L-ornithine + pyruvate. Ornithine plays a key role in the urea cycle, which in mammals is used in arginine biosynthesis, and is a precursor in polyamine synthesis. ceo_syn is related to the NAD-dependent L-alanine dehydrogenases. Like formate dehydrogenase and related enzymes, ceo_syn is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. These ceo_syn proteins have a partially conserved NAD-binding motif and active site residues that are characteristic of related enzymes such as Saccharopine Dehydrogenase.	2.48043e-146

>NZ_CP040750.1|WP_138946608.1|3251271_3252543_+|DUF222-domain-containing-protein
MTETTLTAIRASDEYAAQLAEFSDHYADIQRRRAALDAEEARLLARSAAYADAFADVTVPSIFPPAERQALSRRSTCAALAMATRTPEQAVQRATNDAERLVNDAPAVLASLEAGRISARHAKTITDQLCDVPTDGRAVFLAHVLPVAEQATDAELGRRARVLRERLHPESITARAKRSEADRRVEFEPAADGMAWVHLFTSAPIAQGLIERVEAAAAESRQAGDTRTCAQLQADALAALALTGVTPEDVMSSPVLPHPIEVQEHIRPTVQITVPALSMAGVSDTPATLDGYGPIDPETAARIAVNAPSFTRILVQPETGAVLSVGRNQYRVPADLQRAVRLRDGTCRAPGCGRRARACDLDHSVAWEDGGATDVGNLACLCRHHHRMKHLPGWNLDHGPGGVLEWTTPDGKQYRTEPDPAPF
>NZ_CP040750.1|WP_138946607.1|3249759_3250935_+|alanine-dehydrogenase
MPAASEPTVQHDAVLGVIGTSLKPDERRVPIHPAHFERIPEEFRSRIVVEHGYGARFGVSDEEIAPYVRSFATRAEVVAQADVVLLPKPQLEDVQELRDGQTLWGWPHCVQDTALTQLAIDKRLTLIAFEAMNHWAADGSFGLHVFHKNNELAGYSSVIHALELCGSTGSYGRRLTAVVIGFGATARGAVTALNAHGIHDVRVLTNRRVAAVAAPIHSARMIQFDHDDGPYLSEVITDEGRVPLAPFLAESDIVVNCTLQDPNAPLLYLREDDLGAFRPGSLIVDVSCDEGMAFEWARTTGFDDPMFTVGRGEINYYAVDHSPSLLWNSSSWENSEALLPFLPTVLAGPDAWVDSLTVQRAVEIQDGVILNPAITEFQHRSAEYPHEVQPG
>NZ_CP040750.1|WP_137242059.1|3248830_3249484_+|hypothetical-protein
MTMGVWRKSRRKPMKPYVAPPEVAPPPVEHAVEEGLLIARSWTVVEVTNWIIERALRDGASYDAEATQAAVRRELGRMADEQEEYADLAREARQTAFQRRGSARHQHDYRAGDLSALSRRREVYSGLAAELRRVSKDEEFVAAIAESARERAWGDLERAIQAKLDRVLDEPVVDEHYRRARSQRLRWFRDLDLAALIAANPKDGSMPVDDGPNPYED
>NZ_CP040750.1|WP_138946606.1|3247697_3248723_+|hypothetical-protein
MDGGFLSGGVIILVAAMLWLVYLVPSWVRDSQFSASERNAIRLQQTLRVLAETAEVPEAVRLEATSREVAAQRKLLKQLEARTKATAEAAARVELAEADRIRREEEARAVQAEAAARAAEDARRAAAAAARAVQRNARAAKLARSRRRSRLLATTVLVASIIGFCSGVTAFLAGGGLVLGITSTVVGLLALSALSRMSRIAHRAVAPVPAVAVTTRRVESALFEYNEPVKAASQAQTWTPTSIPKPLHLSEGSSAAAELAKADAYDRLRQAAMQEAIASRAERLAPVVPTIVRRPEPVAAPKPERVEPQQAPSRFASMGVIDEGEIAAGGSTLLQRRRAAG
>NZ_CP040750.1|WP_138946605.1|3246959_3247613_+|GNAT-family-N-acetyltransferase
MAQVVPVLSSGRVSIRPIKVRDARPLERELAENRAWLRRWEATSPYGPVPADSRAAIRSLQNHARSGAGLPFVIEVDGEFAGQLNVSGITYGSLASASIGYWVSQRFAGLGATPIATALATDHCFTALQLHRLEICIRPENAPSLRVVEKLGFRYEGLRRRFIHIDGDWRDHFCFGLVREEVPGGVLNRWLDGQVPKDACVIPESDRLAAASPFPTR
>NZ_CP040750.1|WP_124768911.1|3245944_3246838_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MTTRVTKAVIPAAGLGTRFLPATKALPKEMLPVVDKPAIQYVVEEAVSAGLADVLMIIGRNKNALANHFDRVTELELNLAKKGDTQRLEKVNESSELADIHFLRQGDPKGLGHAVLRAKRHVGHEPFAVLLGDDLIDARDVLLERMLDEQDKRNATIIALMEVDPDSIHMYGAAAVEATDDPDVVRVTGLVEKPAKEDAPSNLAIIGRYVLKPEVFEILERTEPGKGGEIQLTDALQEMAADVEGTGGVYGVIFRGRRYDTGDRLDYIKAIVQLAVDREDLGPELRPWLKGFAGNLD
>NZ_CP040750.1|WP_138946604.1|3245191_3245791_-|5-formyltetrahydrofolate-cyclo-ligase
MTSPAEHEKRALRAELRERRELLTSLEKERSTTGLTDNLRALVSRFGASSIACYLSSPSEPDTRPFLQWAQEAGIRILFPITRTDGLLDWTIGEEGIETVGFAGTPEVVGTTLGPIAINDVDLILVPAAAVDARGMRMGWGRGYFDKTLGSMERCPPVYAVLYDTEILDEVPSEIHDEPVGGAVTPSRILDFDQVRPRR
>NZ_CP040750.1|WP_138946603.1|3244811_3245159_-|FmdB-family-transcriptional-regulator
MPTYAYRCTECGNAFDVQQSFTDDSLTECPACSGKLRKLFSAVGVTFNGSGFYRTDSRAGAGKGSSSIPASSKSSEGSSSSSSSDAKSGSSSSSGSSSSSSGSSATPASAGSTAS
>NZ_CP040750.1|WP_124768909.1|3244313_3244760_-|large-conductance-mechanosensitive-channel-protein-MscL
MLKGFKEFILRGNVIDLAVAVVIGAAFTAIVNSLVENIFNPLLGALFRAESLNDAFNVSIPTVDGDPAVIHFGAFIGATIQFLLVAAVVYFVIVLPMNHFKRVTTKPTIADEAAAPSELSLLTEIRDVLKTGTSAPLPPARDDTTDGR
>NZ_CP040750.1|WP_138946602.1|3244061_3244277_+|hypothetical-protein
MHDDQEPRIVRPRGSRRAIRPGAPGTDPAPQLPAGPVKAAEDTDAAWGGTTKPAGGGGNDDELQRNVPPHW
>NZ_CP040750.1|WP_079705400.1|3254266_3254947_+|MurR/RpiR-family-transcriptional-regulator
MRRRPRVNDDTLFLTDEDTAVPGERPEQRLERRSASVLKHRLLEQERKQFEESLASAKADGALERAAALIVSARRRFLIGASKSFTYASLLAADLSYGLANVTLIDGTIVRPLDVLSDVRTSDVMIAVSLQRYRKYTIDSVVPFAEAGGSLVLITDAPDAPLTPYADETIVLGRAEDGHPSSSIGIALTLHILATLTTASAKGAGRRAVERERLAETLGVYVSDED
>NZ_CP040750.1|WP_138946609.1|3254960_3256424_-|MFS-transporter
MSNTSTSGRPAPVRSLVPARMDRLPWTRFHWMIVVGLGFSWVLDGLEIQIVASAGFQKSLGLSAAEVGLLGTIYLLGQVTGALVFGRMADRLGRKKLFILTLAIYLVASGIAGLSPTFWFLAIFRFFAGMGIGGEYAAINSAIDELIPSKYRGHVDIAINGTYWGGAALGSAANLFLLNTDYFAEDVGWRIGFFIGPVLGLAIIFLRRHIPESPRWLMTHGREQEAEATVDDIEATVRKQGGTIEPVDESKALTVQAQGHIPIRTIFGVLFSKYPKRTFVGLAMMITQSFLYNAIFFTYALVLQNFYGTSPSSTQYYFFPFAIGNLLGPLLLGRLFDTWGRRQMIFLTYGVSGAVLAVSAVLFNAGALDATTQTIFWCVSFFFASAGASSAYLTVSEIFPLELRSQVIGYFFAIGQIAGSVAPLLYGILIGDGTDRGPLTVGYIVGAGVMVLGGLIALIFGVDAARKSLEDITEPLSIVREGKGSGS
>NZ_CP040750.1|WP_138946610.1|3256653_3258114_+|serine-hydrolase
MHLVEDSTETDITRVFQDRIASGVAPGSYVAVFDRERVRFEQGFGGVTVGGPVPDADTLFRIASCTKSFTAAVLLILRDAGRLDLDAPVDGFVPEFAPVLPDGIAVRPTVRMLLTMSGGLGTDDPWGDRQESISVDEFRRLLVRGVRCVTTPGTAFSYSNLGYALLGQVIERVTGGSYIDAVTSLLLEPLGLGAVFERPEGDGAVTATGHRVRRERAVDEDGRFVEVPFSGPGVFSSIGGLFASASTLIGWARWLDGAWTGDETGPLSSASRREMQQLHRLAPSRPTLDGVPPRLALGYGFGLFVEEDADLGTLVSHSGGYPGYSAHMRWHPTSGFGVVAFENAGYAAVAKPAEQALRLAIAGAQASGELPEPAIRPWPETLVASMTATGLLSHWDDRVAASLFAENVALDRPLDERREAVDTAVTAVGGIAEVASGRATPICDSPDHLVWFVEGTEGRLRLEVRMTPVLPLRVQTFTVTVDDQGE
>NZ_CP040750.1|WP_079001938.1|3258176_3258428_-|response-regulator
MSQTLAKLTGGPLDSEIIPLEDGQDGELVLPYGEGQLIYRPVGEATNTGDHDGPTTTDYEYVESTEDISPTNRNGNGDDDSIG
>NZ_CP040750.1|WP_138946611.1|3258453_3259437_-|galactose-mutarotase
MRQNGAVTESTSAVSPSASVDRRPISGRRVDLEHGAYTASIASVGASLRFLRHEGRDLVVPFDAEEVRPAFRGAMLAPWPNRVVDGRYTFAGVDHQLTLTEPARGHALHGLAAWSEWDLVASSAASAAFRVIIEAQEGYPFRVQVTATYTLDDDGLRTDVEALNLGDVDAPYGTGPHPYLVAGEGRVDDWTLELPAAEVLTVTPDRLIPVSLEPVDTEATEHFDFREPRTIGDTFIDHAYTALDRDVDGRVTVRVTTPSGSGVAMHWGDGLPWVQVHTADQPVAELNRLGLAVEPMTCPPDAFSTGTDLVVLAPNTPHRVSWTIAAL
>NZ_CP040750.1|WP_138946612.1|3259491_3261063_-|MFS-transporter
MLTGGVLRLLTRRPLRRAAVRLLRVGRRCIGHGSGLSTERRAERVNCPAARLQFVSSAYLRRTGAGGHILHQNGDVSTAPTTPRTRSERLDALPFTKAHGRLLVGSGVGWALDAMDVGLVSFVLAQLAVQWQLGNTELSWIASAGFLGMAIGATLGGLLADRVGRRHVFAITLLVFGIATGASALAWGLGVLIVLRFIVGLGLGAELPVASTLMSEFAPPRIRGRIIVFLEAFWAIGWIAAALIGYLVVPTSDDGWRWALAIGALPAVYAAIVRTRLPESVRFLESRGRHREAEDVVREFEASAGVAHPEAAGETTTDTLVSVGLSAGQRLRGLWVPTHRRDTGALWIVWFCVNFSYYGAFIWIPTILVASGFSLVRSFGFTLIITLAQIPGYAVSAWLIEAWGRKQTLATFLAGSAVSAVLFGTATTEPMIIVFGMCLSFCNLGAWGALYATTPELYPTALRATGAGWAAGIGRIASIIAPLSVPVLLLAGQALLFSVFAAFFVVAAVAALFLSDMRGRSLD
>NZ_CP040750.1|WP_138946613.1|3260967_3262053_+|hypothetical-protein
MTDAPPPDPQQPDGRPPQWPTGQQPQHPSGQHPQQPYGQQQNPYGQQQPQHGQGPQQQNPSGQQPQPPYGQGPQQQNPYQQNPYGGQQNPSGGQPQQPYQPQQAPYQQQPPQGPPGYGQQPPPPGAPKRKRTGLIIALAVGVPLMLAAIITVVALVLTQGGAPVADPSPTRSATPTKTASPTPTETDSTPEPTKTYVSIPPDLDFAAGQDVPAEWTAYLTNDLDSSWAAIGPDRNGVEIYRNAATSCDVGLGDIALTPDEIAVGDDEKSSDAYMAKYVGADYVKADGTTEQLNYNSGGGLIEFRVLSWTQPSGERTYWGVRSLTKMGILVVFTFTCKDQGSLDLLANDVVNLISVELLPKR
>NZ_CP040750.1|WP_138946614.1|3262065_3263343_-|DUF445-family-protein
MTSSPTLELTAADADRARALRAMKRLATGLLLVMAVIFAVAFALEGRYPWLAYVRAAAEGGMVGALADWFAVTALFRHPLGIPIPHTAIIPKRKDEIGVSLGEFVETNFLSEEVVRQKLASVSVSEKLGGWLSEPANAERVTAEGSIAVRGLLETLSDDDVREVIEALASKHLIDPQWAPNIGRWVEHIVGVGAHHDAVDLLLDRTGEWLSTNPKAFERLVSSRLPTWVPSFVDRLVDDKLYREAVSFVQAVRADPDHQLRHALDGYLGELAEQLQHDDATITRFENAKHEVIDSPRVREVAGKTWTAAKSAFLEALDAPDSDLRVRIAGTIADFGRRLSTDRAFSTRVDTRVADALSYVVTRYRHDIASIITETVERWDARETTQKIELLVGRDLQFIRLNGTIVGALAGLAIFTVAQAVLRAF
>NZ_CP040750.1|WP_064296530.1|3263426_3263705_+|metal-sensitive-transcriptional-regulator
MIEDIKKRALHRTKILEGQMRGLEKMIENEDYCMDIITQSLAIQKSLGSLNKLLVENHLLTHVTQMFEEGGDSKDAAVGELLRIFELSNNRG
>NZ_CP040750.1|WP_138946615.1|3263732_3264923_-|acyl-CoA-dehydrogenase
MTAQAQHHPSDRSFDPASILSDGLVERIRERAAVADRENAFFDEDLAELRACGYLRAFVPEEFGGLGLGLSEVTLLQSRLATAAPATALAINMHLVWTGVARLLHTRGDDSLRFVLEGAAGDELYAFGVSEAGNDLVLFGSDTEARPGPDGSYRFHGRKIFTSLSPAWTWLGTTGLDTTSADGPKVVYGFIERSRGGFEILDDWDTVGMRASQSRTTLLQGAESTAEHIVRRLDPGPNPDPIVFGIFACFETLIAAVYTGIGERALRLAVETAHRKTSKKAGGASYAADPDIRRRIAAAAIAYDGMLPQLAGIARDLDDGVDHGALWFPKLVGLKVRATETAREVVDQAIRVAGGGSYFAASELGRLYRDVLAGMFHPSDDESAHATVANAWLGPV

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Crispr_ID: NZ_CP040750_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_21

3281187-3281445

Orphan

Consensus_repeat	Method
CCGGTCCCTGAGCCTGTCGAAGGGC	CRT

4 spacers

The CRISPR arrays of NZ_CP040750_21

>merge|NZ_CP040750|21|3281187-3281445|CRT
TCGGTCCCTGAGCTTGTCGAAGGGCGCACGAGGGGCCTCCCGCTCCAGGTGGTCCTCCGCCGGTCCCTGAGCCTGTCGAAGGGCCCACGAGGGGCCTCCCGCTCCGGTGATCTTCTCCCGGTCCCTGAGCCTGTTGAAGGGCACACGGAGCACCCCACGAATCCGGCGCCCTTCCACCGGTCGCTGAGCCTGTCGAAGGGCACACGAGGGACCTCCCGCTCTGGTGATCTTCTTCCGGTCCCTGAGCCTGTCGAAGGGC

>NZ_CP040750|21|1|3281187-3281445|CRT
TCGGTCCCTGAGCTTGTCGAAGGGC	GCACGAGGGGCCTCCCGCTCCAGGTGGTCCTCCG
CCGGTCCCTGAGCCTGTCGAAGGGC	CCACGAGGGGCCTCCCGCTCCGGTGATCTTCTC
CCGGTCCCTGAGCCTGTTGAAGGGC	ACACGGAGCACCCCACGAATCCGGCGCCCTTCCA
CCGGTCGCTGAGCCTGTCGAAGGGC	ACACGAGGGACCTCCCGCTCTGGTGATCTTCTT
CCGGTCCCTGAGCCTGTCGAAGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138946623.1\|3277196_3281141_-\|ATP-dependent-RNA-helicase-HrpA	unknown	unknown	gnl\|CDD\|182986
NZ_CP040750.1\|WP_138946629.1\|3287786_3288656_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224050
NZ_CP040750.1\|WP_079705431.1\|3290252_3291188_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270324
NZ_CP040750.1\|WP_138946622.1\|3276278_3277130_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NZ_CP040750.1\|WP_138946625.1\|3283243_3283894_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_056007615.1\|3269883_3270117_+\|glutaredoxin-like-protein-NrdH	unknown	unknown	gnl\|CDD\|131249
NZ_CP040750.1\|WP_056007612.1\|3272993_3273968_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|275027
NZ_CP040750.1\|WP_138946626.1\|3284204_3285116_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP040750.1\|WP_138946627.1\|3285115_3285871_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NZ_CP040750.1\|WP_079705419.1\|3274969_3275350_-\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|226720
NZ_CP040750.1\|WP_124770142.1\|3275446_3276022_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|214900
NZ_CP040750.1\|WP_138946620.1\|3274098_3274608_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_079706251.1\|3270638_3272744_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|236179
NZ_CP040750.1\|WP_079705429.1\|3288652_3289363_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP040750.1\|WP_079705432.1\|3291320_3292100_+\|DUF1684-domain-containing-protein	unknown	unknown	gnl\|CDD\|377941
NZ_CP040750.1\|WP_138946630.1\|3289359_3290163_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224095
NZ_CP040750.1\|WP_064296523.1\|3270201_3270615_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	unknown	unknown	gnl\|CDD\|179603
NZ_CP040750.1\|WP_138946621.1\|3274613_3274841_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138946624.1\|3281515_3282787_+\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP040750.1\|WP_168223415.1\|3286082_3287570_+\|aromatic-amino-acid-lyase	unknown	unknown	gnl\|CDD\|176460

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138946623.1\|3277196_3281141_-\|ATP-dependent-RNA-helicase-HrpA	gnl\|CDD\|182986	PRK11131, PRK11131, ATP-dependent RNA helicase HrpA; Provisional.	0
NZ_CP040750.1\|WP_138946629.1\|3287786_3288656_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	1.72868e-126
NZ_CP040750.1\|WP_079705431.1\|3290252_3291188_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.20351e-121
NZ_CP040750.1\|WP_138946622.1\|3276278_3277130_+\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	2.54585e-84
NZ_CP040750.1\|WP_168223415.1\|3286082_3287570_+\|aromatic-amino-acid-lyase	gnl\|CDD\|176460	cd00332, PAL-HAL, Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL). PAL and HAL are members of the Lyase class I_like superfamily of enzymes that, catalyze similar beta-elimination reactions and are active as homotetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. PAL, present in plants and fungi, catalyzes the conversion of L-phenylalanine to E-cinnamic acid. HAL, found in several bacteria and animals, catalyzes the conversion of L-histidine to E-urocanic acid. Both PAL and HAL contain the cofactor 3, 5-dihydro-5-methylidene-4H-imidazol-4-one (MIO) which is formed by autocatalytic excision/cyclization of the internal tripeptide, Ala-Ser-Gly. PAL is being explored as enzyme substitution therapy for Phenylketonuria (PKU), a disorder which involves an inability to metabolize phenylalanine. HAL failure in humans results in the disease histidinemia.	1.04021e-72
NZ_CP040750.1\|WP_056007615.1\|3269883_3270117_+\|glutaredoxin-like-protein-NrdH	gnl\|CDD\|131249	TIGR02194, Glutaredoxin-like_protein_NrdH, Glutaredoxin-like protein NrdH. NrdH-redoxin is a representative of a class of small redox proteins that contain a conserved CXXC motif and are characterized by a glutaredoxin-like amino acid sequence and thioredoxin-like activity profile. Unlike other the glutaredoxins to which it is most closely related, NrdH aparrently does not interact with glutathione/glutathione reductase, but rather with thioredoxin reductase to catalyze the reduction of ribonucleotide reductase.	1.01477e-31
NZ_CP040750.1\|WP_056007612.1\|3272993_3273968_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	gnl\|CDD\|275027	TIGR04171, ribonucleotide-diphosphate_reductase_subunit_beta, ribonucleoside-diphosphate reductase, class 1b, beta subunit. Members of this family are NrdF, the beta subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	0
NZ_CP040750.1\|WP_138946626.1\|3284204_3285116_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	7.60901e-74
NZ_CP040750.1\|WP_138946627.1\|3285115_3285871_+\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	1.71896e-06
NZ_CP040750.1\|WP_079705419.1\|3274969_3275350_-\|DoxX-family-membrane-protein	gnl\|CDD\|226720	COG4270, COG4270, Predicted membrane protein [Function unknown].	8.77628e-12
NZ_CP040750.1\|WP_124770142.1\|3275446_3276022_-\|flavin-reductase-family-protein	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	4.91118e-32
NZ_CP040750.1\|WP_079706251.1\|3270638_3272744_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|236179	PRK08188, PRK08188, ribonucleotide-diphosphate reductase subunit alpha; Validated.	0
NZ_CP040750.1\|WP_079705429.1\|3288652_3289363_+\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	4.6896e-41
NZ_CP040750.1\|WP_079705432.1\|3291320_3292100_+\|DUF1684-domain-containing-protein	gnl\|CDD\|377941	pfam07920, DUF1684, Protein of unknown function (DUF1684). The sequences featured in this family are found in hypothetical archaeal and bacterial proteins of unknown function. The region in question is approximately 200 amino acids long.	8.63866e-46
NZ_CP040750.1\|WP_138946630.1\|3289359_3290163_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	4.69583e-46
NZ_CP040750.1\|WP_064296523.1\|3270201_3270615_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	gnl\|CDD\|179603	PRK03600, nrdI, class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI.	4.38964e-78
NZ_CP040750.1\|WP_138946624.1\|3281515_3282787_+\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	7.68617e-16

>NZ_CP040750.1|WP_138946623.1|3277196_3281141_-|ATP-dependent-RNA-helicase-HrpA
MGSPDQEARSGSTPRPARYDGGLMSDLRISYPPELPVSAARADIARAISENQVVIVAGATGSGKTTQLPKICLELGRESIGHTQPRRLAARTIAERISEELGQELGGIVGYQVRFTDQASKATKIKLMTDGILLNEIHRDRMLRKYDTIIIDEAHERSLNIDFLLGYLKQLLPQRPDLKVIITSATIDPESFSKHFDGAPIVEVSGRTYPVEIRYRPLVADEPTDDDEDAPESEAADRDYLEGINAALDELARESMGDVLVFLSGETEIRDAADAIRGRNLPGTEVLPLYGRLSSADQHRVFQPSTVAGLRRRIILATNVAETSLTVPGIKYVIDAGTARISRYSVRSKVQRLPIEAISQASANQRSGRSGRTSDGIAIRLYSEDDFAKRPEFTEPEILRTNLAAVILQMISLGLGDIAAFPFLQPPDARGIKDGVDLLSELGAIETRTFADGSPRGGGPRLTRVGRDLSRLPIDPRFARMVVESKQHGVSREVLAIVAALTIQDPRERPLEHRQKADELHRRFVDPTSDFLALLNLWNYLEEKQDELSSSAFRRLCKNEFLNYLRVREWHDVYRQLRQLAKPLGLTINEPAVKPDGIHKSLLAGLLSHIGLKDQTVAPVVKGRNAPPATKTAKKGDYIGARQTRFVLFPGSALAKKQPNAVMSAELVETSRLFARTNASIDPAWAEQIAGDLCKRSYSEPHWEKNQGSAVAFEKVTLFGVPIVPRRRVQFGRIDQEQARELFLRHALVDGEWTHDIGRDKLFDFHRANRRLRKELSELEERTRRRDILFDDEAVFDFYDARVPAEISTTRGFESWWRKTRVDQPELLTMRQEDLLPEDAPAVDEDRFPAEWVQADQRLKLSYRFEPGSDDDGVTVIVPLALLDRLSPAGFDWQVPGLRRDLITAMIKALPKALRRNIVPAADWAAKLLAELPADVPAVAPGSPAAEDSFATRLANAIKRLSYMDITASDFEMERVPEHLLVTFRVIDERGRTLASGKDLVELQQRLKQRTRASVAKVAAARVPNAIERSGFTRWDFDDLPRFIDIRQEDGVIRGYPAIVDDGTSVSIRIMSTEADQARAMPAGVRRLLLLAIPSPTAYVQQHLKANEKLALATSPYRSTPALFEDCLAACIDDVLFRVVPDGQVFSRLQYETLRDRVSASVMDRMFQTVAIVARILQAARDTEKAMKAATSMTLLAALTDMRGQLDGLVFPGFVSRTGSARLEHLPRYLAGIRYRAERLTDNPNRDRVWMTEAQTALARFEAAGGTIPLPAEAPEHLVKARWMLEELRISLFAQQLGTAESVSLQRLQKVLAD
>NZ_CP040750.1|WP_138946622.1|3276278_3277130_+|sulfurtransferase
MPILIAPDDLAALIASETPVRVLDVRWRLDAPDGRPAYLEGHLPGAVYVDLDHELADHVPPGEPAVRGRHPLPDRQALQASARSWGVDDGDVVVVYDDLTSLSAARAWWVLRNAGIADVRILDGAFRAWTDAGLPVERGEVVPEPGTVTLTTGVLPTIDIDTAATWAGEGRVLLDARAGERYRGDVEPIDPRAGHIPGALSTPTTANVGTDGRFLPPETLREQFLAAGVPEDATVATYCGSGVTAAHNAVALTLAGFEPVLYPGSWSEWANHPERPVATGPDA
>NZ_CP040750.1|WP_124770142.1|3275446_3276022_-|flavin-reductase-family-protein
MSPDDFKAAFRQHPAGVSVITADDGSGPVGLTATSVFSVSAEPPLLVFSVSSLSSSAPTITASDTVVVHLLGSEQLHIAKLCATSGIDRFADTSIWDRLPTGEPYFTGNGVWIRGRIVNRMEAGTSTVIAVHALESSVSQPQAAEEPVRAEPAAEAPAPAAPTFSPSFDGAPLVYHNRTWHRLDANSQIDG
>NZ_CP040750.1|WP_079705419.1|3274969_3275350_-|DoxX-family-membrane-protein
MAGSKARTAARLLLGGALVFAGISHLTFARKDFQAQVPEWVPIDEDTTVLASGVVEIALGAALASGVKRTAVGNLAAAFFTAIFPGNLSQWLNRRDAFGLDTDSRRFTRLFFQPVLIAWALWSTRR
>NZ_CP040750.1|WP_138946621.1|3274613_3274841_-|hypothetical-protein
MLTTEATMDELLVAEPVETPSAGRNGVVSLVSLVVILTIVVTAIAALFLPVVQGATAFFYFFLAGFGGISTALGG
>NZ_CP040750.1|WP_138946620.1|3274098_3274608_+|hypothetical-protein
MSATLEQHREAIGPELPGTDVIRAIRALLIWAVLASLVYTALTHATEGICPGGFDGSGGFIDADGGPTDTAPTCLTVSLLPSPIVYGIIGGTIIGVLSVILRRASSQVRALRFISRARWIVCGVALVSILVAQLWFAQLDVTNWDGGPIDVLFPFPFASGSVEISPLHD
>NZ_CP040750.1|WP_056007612.1|3272993_3273968_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta
MSEKLKLVDRVQAINWNKIEDEKDVEVWNRLVNNFWLPEKIPLSNDVQSWNTLTPQEQQLTMRVFTGLTLLDTIQGTVGAVALIPDAITPHEEAVYTNIAFMESVHAKSYSSIFSTLSSTKEIDEAFRWSVENPNLQKKASIVLDRYHGDDPLKRKAASTLLESFLFYSGFYLPMHWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQKGLEKLTQAERDDVKDYTFSLLYELYDNEVQYTQDLYDEVGLTEDVKKFLHYNANKALMNLGYEAMFPKTVTDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVVTEDEDWDF
>NZ_CP040750.1|WP_079706251.1|3270638_3272744_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha
MDYHSLNAMLNLYGPNGEIQFDKDREAAREYFLQHVNQNTVFFHSLKERLDYLVEKEYYEQAVLDKYSFDFIQELNDLAYSKKFRFQTFLGAFKYYTSYTLKTFDGKRYLERFEDRVVMTALGLADGDQQLAVALVEEIIAGRFQPATPTFLNSGKAQRGELVSCFLLRIEDNMESIARGINSALQLSKRGGGVALSLSNIRESGAPIKQIENQSSGIIPVMKLLEDSFSYANQLGARQGAGAVYLNAHHPDILRFLDTKRENADEKIRIKTLSLGVVVPDITFDLAKKGEDMYLFSPYDVERVYGVPFGDISVSEKYHEMVDDSRIKKTKINAREFFQTIAEIQFESGYPYIVFEDTVNKANPIKGRINMSNLCSEILQVNTPTTYNEDLSYKEIGKDISCNLGSLNIALTMDSPDFGRTVETAIRGLTSVSDQSHISSVRSIEDGNDKSHAIGLGQMNLHGYLARERVHYGSPEGIDFTNIYFYTVVFHALRASNLIAKERGETFDGFADSQYASGEFFDKYIDQVWEPETARGRELFEQAGVQIPTQADWTALKASIQEYGIYNQNLQAVPPTGSISYINNSTSSIHPIASKIEIRKEGKLGRVYYPAPFMTNDNLEYYEDAYEIGAEKIIDTYAAATQHVDQGLSLTLFFKDTATTRDINKAQIYAWKKGIKTIYYIRLRQLALEGTEVDGCVSCML
>NZ_CP040750.1|WP_064296523.1|3270201_3270615_+|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI
MQPRLIYFSSISGNTHRFMQKLDLPSLQIPLYAKDEAVHATAPYVLVTPTYGGGNGDGAVPKQVIRFLNVEANRSLIRGVIAAGNTNFGEAYGLAGDVIASKCKVPHLYRFELFGTQDDVTTVHNGLESFWQQRQFQ
>NZ_CP040750.1|WP_056007615.1|3269883_3270117_+|glutaredoxin-like-protein-NrdH
MAITVYTKPSCVQCTATYRALDNKGIEYNILDLSVDENALEQVKALGYLQAPVVITEEDHWSGFRPDKIEELAARLA
>NZ_CP040750.1|WP_138946624.1|3281515_3282787_+|DUF222-domain-containing-protein
MTETTATAIRVGDEYAAQLAEFSDEWAELHRQQAALDARKARLLARSAAYADAFADATVPTVFPPAERQDLSRRSTYAALAMATRTPERTIQRATNDAERLVNDAPAVLASLEAGRISARHAQVITDQLCDVPTAGRAAFLEQVLVVAERTTATGLRTSARVLRERLHPESIIVRAVRSEADRRVEFEPAADGMAWVHLFTTAPIAQGLIERVEAAAAESRQAGDTRTCAQLQADALATLALTGVTPDDIMSSSVLPHPIEVQEHITPTVQITVPALSMAGVSDTPATLDGYGPIDPETAARIAVNAPSFARILVQPETGAVLSVGRNQYRVPADLQRAVRLRDGTCRAPGCGRRARACDLDHSVAWEDGGTTDVGNLACLCRHHHRLKHLPGWNLDHEPGGVLDWTTPDGKHHRTEPDPAPF
>NZ_CP040750.1|WP_138946625.1|3283243_3283894_+|hypothetical-protein
MEPTDGSDALDPAAMLALQERQASRVDDIFTRPTIAIVYIWGVAWTVGFLALWSASDENPWFTTPPTVAGWLFGILMVGGIVSSSIIGSRVSRGIQGAQQVQGTMYGIAWAIGCTAAAVFGGALFAAGMAPALAAIFYPAIYSLVVGLLYLAGGAVWRDRLMYGMGIWIIVVGMAAPFFGSPGNALIMSIAGGGGFLVYATFLEATRRRRAHRSAA
>NZ_CP040750.1|WP_138946626.1|3284204_3285116_+|ATP-binding-cassette-domain-containing-protein
MTITPLATLEGVTRRYGEVTALHDVDLRIEPGSLVGLLGPNGAGKSTVLSLLQGTRRPTTGTVTLFGGDPAQAVNRTRLGSTPQETALPPTLRVGEVVDFVGRHFADRVPTAALAEQFGFGDLLRRQTGSLSGGQQRRLAVALAFVGRPRLVLLDEPTTGLDVDARRTLWDAIRRQHELGATIVLTSHYLEEIEALAERVVVLGGGRVVTDAPLRDVLGLVGIHRVRLRTTDPGAMERLAGVVQASHDGDAVELDVRDADAFVRELVRSEAPFTDLAVRGATLEEAFLTLTADAREDVERSAA
>NZ_CP040750.1|WP_138946627.1|3285115_3285871_+|ABC-transporter-permease
MATTLQLTALHARYSLLETVRVPIALIGSLVFPALSLLFFVVPQAQVAGDPVIATQAVISLIVFAVLANSLFGFGLTIAQAREQAWDPYLRTLPVTGVARVLSHLCSVGLLGFAAVIPVVVLGALLTAATTTPMGLLGSIVALPVGALPFMLIGTAIGYALPSKAAIAVVQVVMFSLAFAGGLFIPPFLFAPWLDRLSMFLPSRQTRELVVWAVQGGELPWWSWVGVLAWTLVLTVVVLALYRRDEGRRYR
>NZ_CP040750.1|WP_168223415.1|3286082_3287570_+|aromatic-amino-acid-lyase
MVFGTGPISVDDLVAVSRDDAIVVLDTPALDRIGAGRAIVDRQTTPVGVGAPGPRSQGPRIPGPAGGRAAPRTATLDASAVEERVVHDRRGGIGLPLSVDRARAVVAARLAGWTRGASGIRLETAVFVAELLNRGVTPVIPSVGSLGDGDETHLASVATLVMGQGEAVLAGERLPAQVALSRVGLAPLDLAVHEGLAFVHHNAYSLGVGALALHRLGALSRLTDTTSALSSRAAARSGLGGWGPAFDPRVLAGSPSAGTRASGERISEVLATSVRSEGARGGRDLDGLRLGSTPQINGALADEVAAAVLLVEATLGTASEDPLVDQASGVLRTGGLLHGARLARTFDGLRAAIAYTAAAAERRLGRIDGGGADRRGTGHGLVPGRLGQSAADLVAELRVLATPVVAAGVPNEDSDAPASFAGTSLRLLERSTALLADVLAVEAVVAADALGPAEHDGWSVGFSVAHAGLRSAIEQELQGQQLVTAALAALGVDRS
>NZ_CP040750.1|WP_138946629.1|3287786_3288656_+|ATP-binding-cassette-domain-containing-protein
MISFEHVSKRFDDGTLAVDDFSLTIPSRSTTVFVGSSGCGKTTLLRMINRMVDPSEGRIVIDDEVVSAVDPVRLRRRIGYVMQNSGLLPHRTVIDNVATVPMLTGVNKKQARADALTLLDTVGLDRALADRYPSQLSGGQQQRVGVARGLAIDPNILLMDEPFGAVDPLVRAELQRELLRLQRDIAKTIVFVTHDIDEAFLLGDQVVILQKGGHIAQVGTPSEIVANPADDFVAQFIGADRGQRTLHVERVDGRDVVVDESGRPAGVLGAGPGAGDRPGLDVRKDGAST
>NZ_CP040750.1|WP_079705429.1|3288652_3289363_+|ABC-transporter-permease
MSWVIANWDMIWDLTLTHVQLSLPPIILGFLISLPLGWLAHRYRWSRGVLLTLSGILYAIPSLPLFVLMPSLIGTKILDPANVVIALTIYAVALLVRTVADALDAVDAGVRQSAQAVGFSTGQRFWRVEFPLAGPLMLAGIRVVSASTISLLSVGALIGVTNLGYLFTDGYNRQFPIEILTGIVGTVVIAIVFDVLLVLLGRLLMPWTRISSKGAIRRRRAATEARELATAGGGAA
>NZ_CP040750.1|WP_138946630.1|3289359_3290163_+|ABC-transporter-permease-subunit
MINFLAAFAWIFDPAHWDGPGGIPVRVLQHLAVTGLTVLIACVIAIPLGLLIGHTGKGREVAVAITGALRALPTLGLLSLLALITLGWGFSSTSLVPAITALVVLAVPPVLAGAYGGVESIDRQTIDAARAVGMNEWQILGKVEIPLALPLMIGGVRSAVLQTIATATVVAFLTNGPGLGRYILDGLPVRDYAQMLAGSIIIIVLALLLEGVFSLLQRAVVPRGVQATHTRVDETRGHATGGDRSTAPDPVVAEAEANMQTAAYRND
>NZ_CP040750.1|WP_079705431.1|3290252_3291188_+|ABC-transporter-substrate-binding-protein
MFTVRQGRRLAVGIAATAVAALALSACSAGDPTAGETAASDTITVGSAGFPESEIIAQIYIQALEANDIKTAESLNIGARDVYIAALEDGSIDLVPDYSGNLLQFFDDSATATSSDEVYSALQEATPKGYEVLDQSKAEDKDSYNVTKEFSEANNVTSLADLAALTIPLAIGGAPELAERPYGPKGLTEVYGVPADKLTFVPISDGGGAQTTAALLDGTVQLADIYTTTPSITENDFVTLEDPENLILPQNVLPLINSAKASDKVKEVLNAVSAELTTEDLIELNARNQGDEKAAPKTLAADWLKDKKLFS
>NZ_CP040750.1|WP_079705432.1|3291320_3292100_+|DUF1684-domain-containing-protein
MSSETPAEFIASWTAWHTARERSVRAPHGIAALRFTHWLTEEATALEGAPGTWRADATGIVGERLTGTGLTTPSGAQIMTDRVELVHGDELHFGDALLRGMERDGVYALRVLDPEAPTRTSLAGISAFAPDVAWIRPARFVPSPDVTVETESIDGHVTTETPVGRVEFELGDEAVSLTVTGGPNGLWAVFSDGTSGDESYRFRFISMPAPTADGHVLVDFNRAYLPPCAFSDHYVCPLPAPNNRLRTRITAGERLPLGQ

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Crispr_ID: NZ_CP040750_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_22

3714349-3714449

Orphan

Consensus_repeat	Method
TCGGTCCCTGAGCTTGTCGAAGGGT	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP040750_22

>merge|NZ_CP040750|22|3714349-3714449|CRISPRCasFinder
TCGGTCCCCGAGCTTGTCGAAGGGTCAGGGTCCTGTTATCGGTCCCTGAGCTTGTCGAAGGGTCAGGGTCCTGTTATCGGTCCCTGAGCTTGTCGAAGGGT

>NZ_CP040750|22|19|3714349-3714449|CRISPRCasFinder
TCGGTCCCCGAGCTTGTCGAAGGGT	CAGGGTCCTGTTATCGGTCCCTGAGCTTGTCGAAGGGTCAGGGTCCTGTTA
TCGGTCCCTGAGCTTGTCGAAGGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_079705686.1\|3710329_3710659_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226391
NZ_CP040750.1\|WP_138946857.1\|3713761_3714334_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235825
NZ_CP040750.1\|WP_085510661.1\|3716115_3716937_+\|ammonia-dependent-NAD(+)-synthetase	unknown	unknown	gnl\|CDD\|234831
NZ_CP040750.1\|WP_138946852.1\|3707613_3708939_-\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|376607
NZ_CP040750.1\|WP_138946856.1\|3712964_3713765_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NZ_CP040750.1\|WP_064295131.1\|3714594_3714819_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138946860.1\|3719389_3720835_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP040750.1\|WP_079705689.1\|3715673_3716024_+\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240572
NZ_CP040750.1\|WP_064295136.1\|3717801_3718002_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_138946859.1\|3718284_3718737_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|239942
NZ_CP040750.1\|WP_138946853.1\|3709021_3710320_+\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|176459
NZ_CP040750.1\|WP_138946861.1\|3720848_3722531_+\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NZ_CP040750.1\|WP_138946850.1\|3705431_3706931_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NZ_CP040750.1\|WP_064295132.1\|3714871_3715492_+\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
NZ_CP040750.1\|WP_138947359.1\|3718804_3719284_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236669
NZ_CP040750.1\|WP_138946858.1\|3717006_3717669_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040750.1\|WP_137241850.1\|3703916_3705428_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NZ_CP040750.1\|WP_138946855.1\|3711159_3712968_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP040750.1\|WP_064295120.1\|3703620_3703920_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NZ_CP040750.1\|WP_138946851.1\|3707046_3707643_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_079705686.1\|3710329_3710659_+\|hypothetical-protein	gnl\|CDD\|226391	COG3874, COG3874, Uncharacterized conserved protein [Function unknown].	0.00316292
NZ_CP040750.1\|WP_138946857.1\|3713761_3714334_+\|hypothetical-protein	gnl\|CDD\|235825	PRK06547, PRK06547, hypothetical protein; Provisional.	4.81212e-32
NZ_CP040750.1\|WP_085510661.1\|3716115_3716937_+\|ammonia-dependent-NAD(+)-synthetase	gnl\|CDD\|234831	PRK00768, nadE, ammonia-dependent NAD(+) synthetase.	1.72049e-173
NZ_CP040750.1\|WP_138946852.1\|3707613_3708939_-\|acyltransferase-family-protein	gnl\|CDD\|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	2.37756e-16
NZ_CP040750.1\|WP_138946856.1\|3712964_3713765_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	8.18929e-25
NZ_CP040750.1\|WP_138946860.1\|3719389_3720835_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	2.11973e-144
NZ_CP040750.1\|WP_079705689.1\|3715673_3716024_+\|metallopeptidase-family-protein	gnl\|CDD\|240572	cd12952, MMP_ACEL2062, Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein. The subfamily includes an uncharacterized protein from Acidothermus cellulolyticus (ACEL2062) and its homologs from bacteria. Although its biological role remains unclear, ACEL2062 contains a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets and a HExxHxxGxxD/S (x could be any amino acid) motif. It may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD motif.	3.15122e-39
NZ_CP040750.1\|WP_138946859.1\|3718284_3718737_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|239942	cd04496, SSB_OBF, SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date oligomerize to bring together four OB folds in their active state. The majority (e.g. Escherichia coli SSB) have a single OB fold per monomer, which oligomerize to form a homotetramer. However, Deinococcus and Thermus SSB proteins have two OB folds per monomer, which oligomerize to form a homodimer. Mycobacterium tuberculosis SSB varies in quaternary structure from E. coli SSB. It forms a dimer of dimers having a unique dimer interface, which lends the protein greater stability. Included in this group are OB folds similar to Escherichia coli PriB. E.coli PriB is homodimeric with each monomer having a single OB fold. It does not appear to form higher order oligomers. PriB is an essential protein for the replication restart at forks that have stalled at sites of DNA damage. It also plays a role in the assembly of primosome during replication initiation at the bacteriophage phiX174 origin. PriB physically interacts with SSB and binds ssDNA with high affinity.	2.87816e-25
NZ_CP040750.1\|WP_064295132.1\|3714871_3715492_+\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	3.24187e-110
NZ_CP040750.1\|WP_138946861.1\|3720848_3722531_+\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NZ_CP040750.1\|WP_138946850.1\|3705431_3706931_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP040750.1\|WP_137241850.1\|3703916_3705428_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_CP040750.1\|WP_138946853.1\|3709021_3710320_+\|DNA-polymerase-IV	gnl\|CDD\|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	2.36245e-158
NZ_CP040750.1\|WP_064295120.1\|3703620_3703920_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	1.87506e-34
NZ_CP040750.1\|WP_138947359.1\|3718804_3719284_+\|hypothetical-protein	gnl\|CDD\|236669	PRK10263, PRK10263, DNA translocase FtsK; Provisional.	0.00143935
NZ_CP040750.1\|WP_138946855.1\|3711159_3712968_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	1.68634e-79

>NZ_CP040750.1|WP_138946857.1|3713761_3714334_+|hypothetical-protein
MSAVPPVLLIDGRSGTGKTTLASSVASALTASTVVHMDDLYPGWEGLDEGARLLVEWILKPFAERRAGEWRRWDWERSARAEAHLVPSDRPLIVEGCGSSSRSSRVCADTVLWLDAPVVQRTDRLIGRGDGVDWLAGWTLQEDTFIERERPDLDAGLRIEATGAPDQVATLVLEVLRRDHTERWSPWLRS
>NZ_CP040750.1|WP_138946856.1|3712964_3713765_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MTSLTAAERSTVLHRRPPLDRVNPVTKVLAVLILSVPLLLTIDWVSASTAVLLEVMLFPLSGLRFTALLKRALPVLVFAPIGGISMLLYAKPGGTEYLSLGFVRVTDNSIELAVAVTIRVLALGLPTILLFARVDPTDLADGLSQIAKLPSRFVLGILAGARMLGLFIDDWRSLALARRARGLGDRGVVRRFASMAFVLLVFAIRRGSKLATAMEARGFGAPIERTWARPSRLGRADLIAVLVTIVIMALALSTAVLAGTFRVVGQ
>NZ_CP040750.1|WP_138946855.1|3711159_3712968_+|ATP-binding-cassette-domain-containing-protein
MGRHDGVLRPRSGPGGRADVRGARVQALRPRSGDPRRGRRRGRRVAPRARDVGQPREGCRVQRDLPRFAARLGRDPRRCRRLGTRQGTRVDRSAQSVRVGAGRSARGLIVPGAAATGPARIVARDWGWRHAGRKAWAVRDLDLVIEPGERVLLLGASGAGKSTLIHALAGVLGGADEGESHGSLLVDGVPPERARGRIGLVLQDPDSQVILSKVGDDVAFGCENLGVEREEIWRRVDASLEAVGLDLPLDHSTSALSGGQKQRLALAGVLAMHPSLLLLDEPTANLDPAGVAEVRDAVARLVDDGSSTLVVIEHRVDIWRELMTRVVVLDADGGVLADGPPDLVLDDVGQRLADAGVWVPGIPLGLAPRPVSGPSAAVLTTDDLAVGRTRAQPVQEHLRLAVPEGAATVIVGPNGAGKSTLALTLAGLLSEITGTVTAAPQLAGRLGPRPIRWKSTELLTRIGTVFQDPEHQFVSSTVRNELGVGLQALRWSRTAIDERVSEILEALGLGRLAEANPFSLSGGQKRRLSVATVLAARPAVMVLDEPTFGQDRRTWLSLVRLLQHELERGATIVSVTHDAGVVEHLGDHRILLEPLELGRRAA
>NZ_CP040750.1|WP_079705686.1|3710329_3710659_+|hypothetical-protein
MTNLVEKLAEQAKGLGVSAAYGEQQDVDGTKLVPVALTYYGFGGGSEGDGDDAPSGGGGGGVSIPVGAYIKTDEGLRFDPNLISLIAVAIPFIWVSGKALAGLIKALKK
>NZ_CP040750.1|WP_138946853.1|3709021_3710320_+|DNA-polymerase-IV
MSRQDGASRRVSAHDADDSGTPILHVDMDAFFVSVELLERPELRGLPIIVGNKEGRSVVTSASYEARRYGVRAAMPVSQAMRLCPSAVVLPPHHGRYREYSDRVMEVFESVTPLVEPLSIDEAFLDVSGAVRLLGSPRTIAALVKQRVLDATGLPCSVGLASTKYVAKLASGLSKPDGLLVVPADETLAFLHPLPVGALWGVGGRTEEQLTNRGIRTIGQLASTPLSMLQRAVGEASGRRLLELANGIDPRGIELARREKSVSHEVTFPTDVSDPTILKRELLNLAGLVAIRLRKGGYAGRTISIRVRYADFSVVTRSRTIGEATNVGRRVYDEAASLFDDLDRGGRLVRLVGVKVDQLVPADEAGAGLWDPDEEWREAEQTIDRVASRFGDLAIAPASLLGKPRRRGLGSRGDSQGAGSTDQPLGPADTER
>NZ_CP040750.1|WP_138946852.1|3707613_3708939_-|acyltransferase-family-protein
MSTRTRTGSAPAVPDLSGRDLALDLVRVACVVTVVIVHLLMVAVAVEPDGTIGISRALEQQPWFDTGTWFGQIMPLFFIVGGFATITGWRSTVRRGGGTSDFLRSRVFRLALPTIPVLLFLAVGLWLAGALGVDPAIIEAVAAGVGSPLWFLAAYLLCQAVAPFLATCHDRHPFLTCAALLAGVILVDVVRYSTGLLGIGLVNLVFVWPLLQQFGFFLADGRLRSVPRLVLVAVVLVSYGALVPITTWLPYSTSMLGNLNPPTLPLVVLGVGQLALLALVHPLLTAIMRTRAARAVVFLIGSRLMTVYLWHLPLIIAVAGLQLALGIPFAEPLSAAWWWTRPVVLLVVAVLLAGVGTLLGRVEHPRKLRLDPERKPAYVAVWIALTSAFIMPFAEISHPLTAAMAAAGAVGSIIAVVLLNPTRRPVERVASGSDQAVDQRS
>NZ_CP040750.1|WP_138946851.1|3707046_3707643_+|hypothetical-protein
MLVEGTMRWQVTEDAPMALMLALAFRDMAGLGDRCVAQLPAVTPGLERIDVAGLDLDALAVQFDGWWTGIARRDTRLFMAEVRPPHFEVFDRALDLQELAYRAYDEAHQWASARIREYERALAGRSPSRLTDVYELIRERQFELRRQSSSFRLDLEVLPICRPGAWVVAPDTIVVSESLRDDREAFREWLRPLVHGLV
>NZ_CP040750.1|WP_138946850.1|3705431_3706931_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MAKDKLLSYEEALELYEPVLGFEVHVELNTKTKMFSSAPNGFGDAPNTNISPVCLGLPGSLPVVNEQAVRYSISLGLALGCSIAPSSRFARKNYFYPDLAKNYQISQFDEPIAFEGSVDVELADGTIVTVPIERAHMEEDAGKLTHIGGSTGRIQGAEYSLVDYNRAGVPLVEIVTKPIYGTEHRAPEIAKAYVSAIRDIVVALGISDAKMERGNLRCDANISLRPRGQEKLGTRTETKNVNSLRSVERAVRYEIQRQAAILKDGGSIVQETRHWHEDTGATSAGRPKSDADDYRYFPEPDLLPVVPSPELIEELRAALPEQPAVRRRRLKSEWGFTDLEFQDVVNGGLLNEITATVEAGAAPAAARKWWTGEISRIANQRDVEATSLVSPEHVAALAALVEEGTLNDKLARQVLEGVIDGEGTPQEVIDARGLALVSDDGPLIAAIDEALAAQPDVLAKIRDGKVQAAGAVIGAVMKAMRGQADAARVRELVLERASQ
>NZ_CP040750.1|WP_137241850.1|3703916_3705428_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MSGLIGLTAAELSSKLRAREVSSVEATQAHLDRIAQVDGDVHAFLHVSDHALDVAADIDARRAAGEDLGELAGVPLAIKDVLVTTDMPSTSGSKILEGYLSPFDATVVARSRAAGLVPLGKTNMDEFAMGSSTEHSAYGPTHNPWDLDRIPGGSGGGSAAAVAAFEAPIALGSDTGGSIRQPAHVTGTVGVKPTYGAVSRYGAIALASSLDQVGPVSRTVLDSGLLHDVIAGHDALDSTSLRDAWPSMAAAAREGARGDVLRGLRVGVVTELNGEGFQAGVKSRFQEALAVLEANGAEIVEVSAPNFEYAVAAYYLILPAEASSNLAKFDSVRFGMRVTPEGGGTVEQVMSATREAGFGPEVKRRIILGTYALSAGYYDAYYGSAQKVRTLIQRDFAAAFDQVDVLVSPSAPTTAFKLGERIDDPLAMYLNDVTTIPANLAGVPGISVPIGLAPEDGLPVGIQFMAPAREDARLYRVGAALEALLESTWGHTLISQAPALGGR
>NZ_CP040750.1|WP_064295120.1|3703620_3703920_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MSEITTEQVAHLANLARIALSQDEIAHLTTELDSIVDNIQKVQQVATPDVPATSHPIPLENVYRDDVVGNTLTREQALQNAPESADGRFKVSAILGEEQ
>NZ_CP040750.1|WP_064295131.1|3714594_3714819_-|hypothetical-protein
MIIAISVLLLVNGVYNVVVWPRFLKRIVADPRARDDQGRATTFLRVHVILISIALVLAALSLVFGVLGLLGVGA
>NZ_CP040750.1|WP_064295132.1|3714871_3715492_+|oligoribonuclease
MSTAGDRLVWIDCEMTGLELEVDELVEIAVVITDFELNILDPGYSVVIKPDQSALDNMGEFVTNMHRTSGLLEEIPNGVSVADAEFQVIEYIQRFVPDESKAPLAGNTIGTDRGFLARYMPRLDAHLHYRNVDVSSIKELARRWYPRVYFNAPSKHGGHRALADILESIRELAYYRGALFVDLPGPSSDDAKQVSEAVVSRYAPNM
>NZ_CP040750.1|WP_079705689.1|3715673_3716024_+|metallopeptidase-family-protein
MLELDTEAFEALVVDELDRLPDEMVDGLDNLVFVVEDRPENGTLDTLGLYDGVALTERDRYGFGEMPDRIIVYREPHLAACETLDELADEIHTTLVHEIAHFYGIDDERLHELGWA
>NZ_CP040750.1|WP_085510661.1|3716115_3716937_+|ammonia-dependent-NAD(+)-synthetase
MREIQARIIAELHVSPTIDPAAEVRSRIDFLKSYLRATHTKGFVLGISGGQDSSLAGRLCQLAAEEVRAEGGEARFVAVRLPYAVQHDEDDAQLALSFIRPDDSVVFNIQRAVDGFEAEYADATGEPLSDFVKGNAKARARMVAQYAIAGQQGLLVVGTDHAAEAVTGFFTKFGDGGADVLPLSGLTKRQGRALLESLDAPERLYLKAPTADLLDGTPGQTDEENLGLSYQQIDDFLEGSEIDPVAAEAIEARYAATEHKRQVPVSKFDTWWR
>NZ_CP040750.1|WP_138946858.1|3717006_3717669_-|hypothetical-protein
MLFAAALFIVAVVVSSLVAAGASRRALRAIVDQRDREQKNVAILALVDAATEASVWNSLTPQEQVLSDRAVAQADTLVRLSPIKGAAVAADWANHQLHEMKRNSATFGYELDPVVEDFRDRLVEWSKKPVRARKDFDGDLRRWRAESSGSEQALVAEQESWVAKQHHEQYAEVKPASTAPASRPGDITRSTGGTINTSTTQRIIDDVAVLEAERKQSSVS
>NZ_CP040750.1|WP_064295136.1|3717801_3718002_-|hypothetical-protein
MPNALSIRPGYWRVTTPDGRVLGNIEAVGADGVPEYRANRFRPAVLGYAPLGSFSDLAVAIDAFRN
>NZ_CP040750.1|WP_138946859.1|3718284_3718737_+|single-stranded-DNA-binding-protein
MNDQITVCGHVATDPKHHRTTSGLDITSFRLASQQRRYDQKQGSWVAQETNWYTVSAFRGLATASATSLVKGQRVIVLGRLRIRDWEQGERRGTSVDIEADHIGPDIGWQPKGSGESPVGAAASPTSAASESTGTGTGEWAPGPPQDTPF
>NZ_CP040750.1|WP_138947359.1|3718804_3719284_+|hypothetical-protein
MRRRSSIAGVRVGVVLGLLGIAVTGCTQPAPEPTATPSQTPTATETAPAAPVLLPEGTATDNLPFFDAVNAATLAANPAAGGQAIIDGLVAAGFPKAEMEVSSDTTSIGEPADSIQFAIRWQGQCILGQNGPATGYHSSVVSQLDTGRCLIGVTRAIDW
>NZ_CP040750.1|WP_138946860.1|3719389_3720835_+|amino-acid-permease
MTANPSPGGEPATEAVFLADKRLAVAPTALAHTLEPRHLALIALGGMIGAGLLVASSTAILAAGPGVILAYALAGVVVVLVMRMLGEMASASPETGSFSAYASRFIGPWAGLAIGWLYWWFWVVVVGIEATAAAQIVSQWVPGLPQWIPALVITVAFLAANLVSVKSFGEFEFWFSSIKIMAVVLFIALGSLIIVGVIPTETATVANLAPTDGGFLPFGIGGVLAALLPIIFSMFGAEVATIAAGESVDPKGAVRRAVNSVVWRILLFYIGSILVVLIVVPWTEITPGISPFVTMLHAAGIPGAGVAMDIIVFTALLSTLNASLYTASRMLFSLGGRGEAPRAVRATTRRGTPAVAILCSAVIGLVCVLLNYLAPDEVFTFLVNSTGAIAIFVWIVIAVAQLRSRRFDQVSASERGDRIGGIRMWGHPWLTVVVVVALVALLVSMFFGGPARLLEVTTSCAIAAAAVIAGVLVQRKRRVRP
>NZ_CP040750.1|WP_138946861.1|3720848_3722531_+|energy-dependent-translational-throttle-protein-EttA
MAEYIYSMVRARKAVGDKLILDDVTMAFLPGAKIGVVGPNGAGKSTILKIMAGIDTPSNGEAKLTPGFSVGILMQEPELDEDKTVLENVQEGVGEIKGKIDRFNEISLAMAEPDADFDALLAEMGVLQEAIDAADAWDLDSQLEQAMDALRCPPSDATVAHLSGGEKRRVALCKLLLQKPDLLLLDEPTNHLDAESVLWLEQHLAQYAGAVLAVTHDRYFLDHVAEWICEVDRGRLYPYEGNYSTYLEKKGERLNVQGKKDAKLAKRLASELEWVRSNAKGRQAKSKARLARYEEMATEAERTRKLDFEEIQIPAGPRLGSTVLEAKKLEKGFDGRVLINDLSFSLPRNGIVGIIGPNGVGKTTLFKTIVGIEPLDAGELKVGETVKLSYVDQSRGGIDPNKTLWEVVSEGLDYIQVGNQEIPSRAYVSTFGFKGPDQQKKAGVLSGGERNRLNLALTLKQGGNLLLLDEPTNDLDVETLSSLENALLEFPGCAVVITHDRWFLDRIATHILSYEGTEENPSNWHWFEGNFESYEEDKIKRLGPDAAKPRRSAYRKLTRD

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Crispr_ID: NZ_CP040750_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040750_23

4309521-4309609

Orphan

Consensus_repeat	Method
CGGTCACTGAGCTTGTCGAAGTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040750_23

>merge|NZ_CP040750|23|4309521-4309609|CRISPRCasFinder
CGGTCACTGAGCTTGTCGAAGTGCGGCACAGCTCGGGGACCGAAGCGGTGCGGACAGACTTCTCACGGTCGCTGAGCTTGTCGAAGTGC

>NZ_CP040750|23|20|4309521-4309609|CRISPRCasFinder
CGGTCACTGAGCTTGTCGAAGTGC	GGCACAGCTCGGGGACCGAAGCGGTGCGGACAGACTTCTCA
CGGTCGCTGAGCTTGTCGAAGTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040750.1\|WP_138944506.1\|4301681_4302896_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP040750.1\|WP_138947148.1\|4296766_4297246_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|369157
NZ_CP040750.1\|WP_138947145.1\|4294491_4296675_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223588
NZ_CP040750.1\|WP_138947144.1\|4292981_4294484_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP040750.1\|WP_138947147.1\|4310004_4310916_-\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP040750.1\|WP_138947143.1\|4292080_4292866_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224049
NZ_CP040750.1\|WP_138947142.1\|4291262_4292084_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP040750.1\|WP_138944505.1\|4300842_4301577_-\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP040750.1\|WP_138947146.1\|4303948_4304608_+\|DUF3817-domain-containing-protein	unknown	unknown	gnl\|CDD\|378962
NZ_CP040750.1\|WP_138944504.1\|4297281_4298262_-\|Ku-protein	unknown	unknown	gnl\|CDD\|238408
NZ_CP040750.1\|WP_168223259.1\|4308793_4308994_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP040750.1\|WP_138944506.1\|4301681_4302896_+\|hypothetical-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	4.73535e-19
NZ_CP040750.1\|WP_138947148.1\|4296766_4297246_-\|VOC-family-protein	gnl\|CDD\|369157	pfam06983, 3-dmu-9_3-mt, 3-demethylubiquinone-9 3-methyltransferase. This family represents a conserved region approximately 100 residues long within a number of bacterial and archaeal 3-demethylubiquinone-9 3-methyltransferases (EC:2.1.1.64). Note that some family members contain more than one copy of this region, and that many members are hypothetical proteins.	6.04643e-63
NZ_CP040750.1\|WP_138947145.1\|4294491_4296675_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	3.72481e-129
NZ_CP040750.1\|WP_138947144.1\|4292981_4294484_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.17124e-45
NZ_CP040750.1\|WP_138947147.1\|4310004_4310916_-\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	7.19673e-10
NZ_CP040750.1\|WP_138947143.1\|4292080_4292866_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224049	COG1124, DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.78203e-98
NZ_CP040750.1\|WP_138947142.1\|4291262_4292084_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.63648e-102
NZ_CP040750.1\|WP_138944505.1\|4300842_4301577_-\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.82763e-32
NZ_CP040750.1\|WP_138947146.1\|4303948_4304608_+\|DUF3817-domain-containing-protein	gnl\|CDD\|378962	pfam12823, DUF3817, Domain of unknown function (DUF3817). This domain is of unknown function. It is sometimes found adjacent to pfam07690 and pfam03176 which are both transporter domains.	5.51845e-25
NZ_CP040750.1\|WP_138944504.1\|4297281_4298262_-\|Ku-protein	gnl\|CDD\|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	1.77934e-111

>NZ_CP040750.1|WP_168223259.1|4308793_4308994_+|hypothetical-protein
MLADEVVERAAGDGELEHARIERCVFEELGDEASVGFAGALGAAQRLAGGRTETPEAARPANCTRR
>NZ_CP040750.1|WP_138947146.1|4303948_4304608_+|DUF3817-domain-containing-protein
MGSPTSCGSPRALTAIVCVCIHIGEPRRSDGYSRSTQGGRTGRPLGAPSQPSLASWNTCTPSLGAPVSPRRLFRLIAIAEAITWTLLIIGMILKYVTKTTDVGVSIGGALHGFVFLVYGATVLLIGINQRWPIGTILVGLVSAVVPYATIPFDLWADRTGRLDGAWRREAGADPRDQRVLDRLTRWLVRHPILLVVVGGLVVVAVFTALLVVGPPVPKG
>NZ_CP040750.1|WP_138944506.1|4301681_4302896_+|hypothetical-protein
MTQEARTARAERWSDSRAFITASGAMAAVFGLAVSFQSVYIYTWVAPGGTRGMLAERVTANLVSLSAAILVLALLLWSRWGPSLHEWWRPKVLAGVLLVAMLTGLLRSGLQLLLGVYRDPSLQTVIVEAGTTTLALAVCATFGFSLSAARRRAREEERAHADQRHRADLALQSLQGEELRVKREVAEGLHGTLQQHLVLISAQLASVTTALEQGGPDVGSDAARTLRSLGEELRTVRERDVRELSRLLSPPLLEVGIAPSIRAILQRLPPSITTSLDVSPDFRLLDDPIDNVFTTAERAVVVRTLEEGVTNALTHGAADRLVVDLRVSSPATERRGTMAGAVELRVVDNGSGLRDDAEPSGGLLQLDRRAGAFGGSLRVGPAPDDETGGTVLTLTMPYRSPAIR
>NZ_CP040750.1|WP_138944505.1|4300842_4301577_-|response-regulator
MHHQSHSDPSPAALSTVGDATTAAATTRPLRVGVIEDQPLLGGMLAELLEGAPGVEFVGRAGTVAEARRLFLPGTVDVLTMDIELPDGNGVSLGVSLRRAQPGLGVVLLSAYDLMDMLLEMPADVRDGWSYLSKTSSLTREILLEAIRVSARGETMLDPELIDRTRPRAGSSLESLTDRQYAVLQLLATGRSNTGIATRLGIAEKSVQNHLTAIYAALGIEHDTSSNPRVSAVLALLAESGRLS
>NZ_CP040750.1|WP_138944504.1|4297281_4298262_-|Ku-protein
MRAIWKGAVTFGLVNVPVKVYSATEDHDVSLHQVHDADGGRIRYQRKCEVCGKVVTYDHIDKAYQDGEQTVVLTADDLASLPEERSREIEVVEFVPSDDLDPIMFDRSYFLEPDSSSSKAYVLLRRTLEETDRTAIVRFALRQKTRLGALRVREDVILLQTLLWEDEVREVRFPALEERVRISAKELEMSEALVESFSSRFRPDAFVDEYQAQLRKLIDAKLEQGDALDTAATFGEQPEPDDDTGAEPIDLMEVLQRSIERQRGTTGAKTASGAKRSGAAKPAARSGSAKAGTAKTGTAKTSGAKTGTDKTAASKPSTATKRKKSA
>NZ_CP040750.1|WP_138947148.1|4296766_4297246_-|VOC-family-protein
MEHRVTPFLWYDSQAEEAATFYVSLFPGSRITSVSRYPEGGPMPAGQAMVVEFELEGLPVSAMNAGPIFSFTEAFSFSVRADTQDEIDRLWDALIADGGAPSQCGWLKDRWGLSWQIVPGILAELQNDPDRERAARAMQCMMGQTKLVIAELVAAADGR
>NZ_CP040750.1|WP_138947145.1|4294491_4296675_-|DEAD/DEAH-box-helicase
MSHPSAPTPAHLEPAPTGTVAEATAALAALTGVPGATFHDGQLEAILALVDEHRRALVVQRTGWGKSAVYFIATALLRRRGAGPTLLVSPLLALMRDQVAAAERAGVRAVAINSANAHEWDDVRARLEADEVDVLLVSPERLNNPRFRDEQLPTLVARAGMLVVDEAHCISDWGHDFRPDYRRLAELIGRLPAEVPVLATTATANARVVRDIAEQLTAPGAAGSHGAEVLTIRGSLARASLRLGVLRLPESRDRLTWLLSHLGGLTGSGIIYTLTVSAAEDTARLLREAGHEVRAYTGRTDPDEREESERLLKENRLKALVATSALGMGFDKPDLGFVVHLGAPSSPVAYYQQVGRAGRATEHADVLLLPGAEDEEIWQYFATASMPDEARATAVLDALDSQPRSTPALEALVNLRRTPLELLLKVLDVDGAVQRVAGGWVSTGQPWVYDRERYRRIAEARVAEQQAMLAYERGDECRMLVLQRELDDASAVPCGRCDRCAGPWFPTELDSAAAASASEALGRVGVELEPRAQWPTGADRLGVTADGSAVKGRIALEDRLEPGRALARLTDLGWGGVLRELFAAGAPDAPASRAVIDASVRVLADWPWTQRPAAVVSVPSRSRPQLVDSVARGIASLGRLPYLGELDLVGDGPRGGPGGNSAYRLAGVWDAFSIGSELRAQLAALEGAPVLLVDDRADSRWTLTVAGRALRRAGSGPVLPFALGIVG
>NZ_CP040750.1|WP_138947144.1|4292981_4294484_+|MFS-transporter
MTQDSAQPDDHDEDQAGAEQSWLSDEERAALSKPLPERAVVTSLAFTGLVAAFMMTLVSPLVPSLPTILGVHASDSMWVVTATLLSAAVATPIAGRLGDLYGKRRMVLVLLGIMMAGSVLAAFSSTIVPLIVARALQGMAMGVIPLGISILRDVLHAKRLGPAVALVSATLGIGGAVGLPISAVISQYLDWHVLFWVAGALGLIGFVLVARFVPVSTLRSEGGFDWIGAIGLAAGLVPILLAVSKGNEWGWTSVGTLSCLIGGVVVLLLWGWFEVRSASPLVDLRIAARRTVLFTNLASITVGFAFFGSTVVLPGILEAPVGTGVGLGQNMLIASLCLMPSGLIMWAMSPVAARLTAAKGARLSLLIGIAIIAVGYAIAIGLMTEVWHTVLTATAVGFGVGFAYAAMPTLIMGAVPPSETAASNGLNSVMRTLGSTIASAVIGAILASQVVTDGAVTTPSADAFRLSFAICAAAAVVGLVCTILLPRHLAKDTRSSLHEG
>NZ_CP040750.1|WP_138947143.1|4292080_4292866_+|ATP-binding-cassette-domain-containing-protein
MTTDAPITTPPILELDAVGFRYRGGQEALDDVSLAVGAGEAVGIVGQSGAGKSTLLRLLLGLDRPTTGSVRFDGGALDPRDRTRVRRFRASVQAVFQDPYSSLDPRQRIGRIVAEPLRSLRLATTEQAAVRASEALEAVGLPADAASRFPHEFSGGQRQRIAIARAIVPNPRLLLADEPVSALDMSTRIQIIELLAELRASNGLALVMVSHDLGTVAALCERTMVLRHGQVVEAGATAQILHDPAEAYTKQLIAAIPRLPR
>NZ_CP040750.1|WP_138947142.1|4291262_4292084_+|ATP-binding-cassette-domain-containing-protein
MSDLLDISGLTITRGIRRGAPDGADRPLLDGLDLTIAAGGRLGLIGGSGSGKSLTSLAVIGLLGEQLSASGSVELDGTQVIGAPDRALRPLRGRVAGLVFQEPLTALDPLMRVGAQLAEPLRRHLGLRGERLKAAVEAALVEVSLTDTARIAASYPHELSGGQRQRIAIAIALAGRPQLLIADEPTTALDVTVQAEVLALIDRLVRERGMALLFISHDLAVVSTMVDEVVVLSEGRAVERGPVAQVLTAPRHEDTRRLVASARALDDALEDPR
>NZ_CP040750.1|WP_138947147.1|4310004_4310916_-|DUF222-domain-containing-protein
MTETTLTAIRVGDEHAAQLAEFSDEWTEIHRQQASWMHARRALARSAAYADAFADVAVPASFPPAERRALSRRSTCAALAMATRMPERTVQRATNDAERLVNDAPAVLASLEAGRISARHAQVITDQLCDVPTAGRAVFLEQVLVVAERSTAAGLRMSARVLRERLHPESITARATRSEADRRVEFEPAADGMAWVHLFTTAPIAQGIVERVETAAAESRNAGDTRTCAQLQADALTALALTGVTPEDVMSSPVLPHPIEGPGAHQADRADHGAGVDHGRRERRPGHLYGYGPSTRRPPRVSR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP040750_16	16.2\|2519302\|51\|NZ_CP040750\|PILER-CR	2519302-2519352	51	NZ_CP040750.1	2519610-2519660	0	1.0
NZ_CP040750_16	16.4\|2519456\|51\|NZ_CP040750\|PILER-CR	2519456-2519506	51	NZ_CP040750.1	2519610-2519660	0	1.0
NZ_CP040750_16	16.3\|2519376\|57\|NZ_CP040750\|PILER-CR	2519376-2519432	57	NZ_CP040750.1	2519684-2519740	1	0.982
NZ_CP040750_16	16.5\|2519530\|57\|NZ_CP040750\|PILER-CR	2519530-2519586	57	NZ_CP040750.1	2519684-2519740	1	0.982

1. spacer 16.2|2519302|51|NZ_CP040750|PILER-CR matches to position: 2519610-2519660, mismatch: 0, identity: 1.0

ggtgcatccgggtgatcctcttcggttgaccgaggttgcgcggcttggctg	CRISPR spacer
ggtgcatccgggtgatcctcttcggttgaccgaggttgcgcggcttggctg	Protospacer
***************************************************

2. spacer 16.4|2519456|51|NZ_CP040750|PILER-CR matches to position: 2519610-2519660, mismatch: 0, identity: 1.0

ggtgcatccgggtgatcctcttcggttgaccgaggttgcgcggcttggctg	CRISPR spacer
ggtgcatccgggtgatcctcttcggttgaccgaggttgcgcggcttggctg	Protospacer
***************************************************

3. spacer 16.3|2519376|57|NZ_CP040750|PILER-CR matches to position: 2519684-2519740, mismatch: 1, identity: 0.982

aaatggttcgggcgcacttcttccggtcactgagcttgtcgaagtgcgcacgaggaa	CRISPR spacer
aaatggttcgggcacacttcttccggtcactgagcttgtcgaagtgcgcacgaggaa	Protospacer
*************.*******************************************

4. spacer 16.5|2519530|57|NZ_CP040750|PILER-CR matches to position: 2519684-2519740, mismatch: 1, identity: 0.982

aaatggttcgggcgcacttcttccggtcactgagcttgtcgaagtgcgcacgaggaa	CRISPR spacer
aaatggttcgggcacacttcttccggtcactgagcttgtcgaagtgcgcacgaggaa	Protospacer
*************.*******************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP040750_21	21.1\|3281212\|34\|NZ_CP040750\|CRT	3281212-3281245	34	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	253686-253719	7	0.794
NZ_CP040750_21	21.1\|3281212\|34\|NZ_CP040750\|CRT	3281212-3281245	34	NZ_CP022791	Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence	1128767-1128800	11	0.676
NZ_CP040750_21	21.1\|3281212\|34\|NZ_CP040750\|CRT	3281212-3281245	34	NZ_CP016905	Ralstonia solanacearum strain KACC 10709 plasmid unnamed1	1957816-1957849	11	0.676
NZ_CP040750_21	21.1\|3281212\|34\|NZ_CP040750\|CRT	3281212-3281245	34	NC_011887	Methylobacterium nodulans ORS 2060 plasmid pMNOD02, complete sequence	304453-304486	12	0.647

1. spacer 21.1|3281212|34|NZ_CP040750|CRT matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.794

-gcacgaggggcctcccgctccaggtggtcctccg	CRISPR spacer
agctcga-cggcctcccgctccagccggtcctcgc	Protospacer
 ** ***  *************** .*******

2. spacer 21.1|3281212|34|NZ_CP040750|CRT matches to NZ_CP022791 (Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.676

gcacgaggggcctcccgctccaggtggtcctccg	CRISPR spacer
atcagcatggcctccagctccacgtggtcctcgc	Protospacer
..  * . ******* ****** *********

3. spacer 21.1|3281212|34|NZ_CP040750|CRT matches to NZ_CP016905 (Ralstonia solanacearum strain KACC 10709 plasmid unnamed1) position: , mismatch: 11, identity: 0.676

gcacgaggggcctcccgctccaggtggtcctccg	CRISPR spacer
atcagcatggcctccagctccacgtggtcctcgc	Protospacer
..  * . ******* ****** *********

4. spacer 21.1|3281212|34|NZ_CP040750|CRT matches to NC_011887 (Methylobacterium nodulans ORS 2060 plasmid pMNOD02, complete sequence) position: , mismatch: 12, identity: 0.647

gcacgaggggcctcccgctccaggtggtcctccg	CRISPR spacer
aggatgcgggcctgccgctgcaggtggtcctgga	Protospacer
. .  . ****** ***** ***********  .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1177820 : 1225570

Gordonia_phage(18.75%)

tRNA,terminase,tail,capsid,portal,protease,integrase

attL 1192800:1192815|attR 1201034:1201049

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085514014.1\|1177820_1179161_+\|tRNA	aspartate--tRNA(Asn) ligase	A0A2K9L0E9	Tupanvirus	5.8e-70	34.8
WP_138945216.1\|1179179_1179632_+	nitric oxide synthase	NA	NA	NA	NA
WP_138945217.1\|1179721_1180498_+	putative protein N(5)-glutamine methyltransferase	NA	NA	NA	NA
WP_079706641.1\|1180516_1180825_-	Dabb family protein	NA	NA	NA	NA
WP_138945218.1\|1180865_1181126_-	glutaredoxin family protein	NA	NA	NA	NA
WP_064294610.1\|1181318_1181618_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_137243973.1\|1181660_1181969_-	hypothetical protein	NA	NA	NA	NA
WP_003792170.1\|1182215_1182314_-	AURKAIP1/COX24 domain-containing protein	NA	NA	NA	NA
WP_079706638.1\|1182453_1182648_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_064294613.1\|1182774_1183179_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_079003294.1\|1183251_1184694_+	potassium transporter Trk	NA	NA	NA	NA
WP_056013885.1\|1184686_1185358_+	TrkA family potassium uptake protein	NA	NA	NA	NA
WP_138945219.1\|1185365_1185824_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_138945220.1\|1185887_1186487_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_138945221.1\|1186483_1186987_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_138945222.1\|1187003_1187846_-	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.6e-25	32.8
WP_168223320.1\|1187894_1189016_-\|protease	MarP family serine protease	NA	NA	NA	NA
WP_137244306.1\|1189193_1189640_-	nucleoside deaminase	S4VYZ2	Pandoravirus	4.8e-05	39.8
WP_079003301.1\|1190855_1191563_+	winged helix-turn-helix transcriptional regulator	W8CYM9	Bacillus_phage	2.2e-07	44.3
WP_138945224.1\|1191643_1192651_-	DMT family transporter	NA	NA	NA	NA
1192800:1192815	attL	NA	NA	NA	NA
WP_138945225.1\|1194024_1194669_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_138945226.1\|1194665_1195283_+	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_138945227.1\|1195275_1195644_+	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_138945228.1\|1195704_1199391_-	hypothetical protein	NA	NA	NA	NA
WP_138945229.1\|1199782_1200586_+\|integrase	tyrosine-type recombinase/integrase	A0A0K0N6I5	Gordonia_phage	4.2e-23	32.0
WP_138945230.1\|1200664_1201060_+	hypothetical protein	NA	NA	NA	NA
1201034:1201049	attR	NA	NA	NA	NA
WP_138945231.1\|1201059_1201350_+	hypothetical protein	NA	NA	NA	NA
WP_138945232.1\|1201384_1202596_+	hypothetical protein	NA	NA	NA	NA
WP_138945233.1\|1202592_1204518_-	hypothetical protein	NA	NA	NA	NA
WP_138945234.1\|1204553_1204844_-	hypothetical protein	NA	NA	NA	NA
WP_138945235.1\|1204946_1205318_-	hypothetical protein	NA	NA	NA	NA
WP_138945236.1\|1205314_1205767_-	hypothetical protein	A0A2R4A2L0	Microbacterium_phage	2.1e-11	27.2
WP_138945237.1\|1205795_1206680_-	N-acetylmuramoyl-L-alanine amidase	A0A2P1CFS5	Microbacterium_phage	3.5e-15	35.9
WP_138945238.1\|1206682_1207225_-	hypothetical protein	NA	NA	NA	NA
WP_138945239.1\|1207286_1208186_-	hypothetical protein	NA	NA	NA	NA
WP_138945240.1\|1208182_1209286_-	hypothetical protein	NA	NA	NA	NA
WP_138945241.1\|1209285_1210188_-	hypothetical protein	NA	NA	NA	NA
WP_138945242.1\|1210348_1212871_-\|tail	phage tail tape measure protein	I3NL90	Bifidobacterium_phage	7.6e-71	41.8
WP_138945243.1\|1213169_1213331_+	MoaD/ThiS family protein	NA	NA	NA	NA
WP_138945244.1\|1213495_1213717_+	hypothetical protein	NA	NA	NA	NA
WP_138945245.1\|1213713_1213938_+	hypothetical protein	NA	NA	NA	NA
WP_138945246.1\|1213971_1214328_-	hypothetical protein	NA	NA	NA	NA
WP_138945247.1\|1214396_1214996_-	hypothetical protein	NA	NA	NA	NA
WP_168223321.1\|1215078_1215468_-	hypothetical protein	NA	NA	NA	NA
WP_168223322.1\|1215559_1215721_-	hypothetical protein	NA	NA	NA	NA
WP_138945249.1\|1215777_1216167_-	hypothetical protein	NA	NA	NA	NA
WP_138945250.1\|1216183_1216588_-	hypothetical protein	NA	NA	NA	NA
WP_138945251.1\|1216596_1217004_-	hypothetical protein	NA	NA	NA	NA
WP_138945252.1\|1217000_1217474_-	hypothetical protein	NA	NA	NA	NA
WP_138945253.1\|1217639_1218536_-\|capsid	phage major capsid protein	A0A2H4IYA3	uncultured_Caudovirales_phage	4.4e-114	69.2
WP_138945254.1\|1218551_1219022_-	hypothetical protein	A0A2H4PEW6	Gordonia_phage	1.7e-16	39.9
WP_138945255.1\|1219104_1219764_-	hypothetical protein	G1BSM8	Mycobacterium_virus	3.2e-21	37.8
WP_138945254.1\|1220097_1220568_-	hypothetical protein	A0A2H4PEW6	Gordonia_phage	1.7e-16	39.9
WP_138945255.1\|1220650_1221310_-	hypothetical protein	G1BSM8	Mycobacterium_virus	3.2e-21	37.8
WP_138945256.1\|1221296_1222700_-\|portal	phage portal protein	A0A2H4J2P6	uncultured_Caudovirales_phage	7.0e-143	58.4
WP_168223323.1\|1222696_1224133_-\|terminase	terminase	G9FH27	Rhodococcus_phage	4.1e-98	45.1
WP_138945257.1\|1224161_1224458_-	hypothetical protein	NA	NA	NA	NA
WP_138945258.1\|1225276_1225570_-	HNH endonuclease	A0A222ZN30	Mycobacterium_phage	2.8e-17	50.0

DBSCAN-SWA_2

1230370 : 1236493

Mycobacterium_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_138945268.1\|1230370_1230787_-	single-stranded DNA-binding protein	A0A1L6BYK5	Mycobacterium_phage	2.3e-09	34.0
WP_138945269.1\|1230783_1231005_-	hypothetical protein	NA	NA	NA	NA
WP_138945271.1\|1231204_1231642_-	hypothetical protein	NA	NA	NA	NA
WP_138945272.1\|1233062_1233488_-	hypothetical protein	S5W0K5	Mycobacterium_phage	3.2e-06	33.6
WP_138945273.1\|1233484_1233703_-	WhiB family transcriptional regulator	A0A2H4PFS1	Mycobacterium_phage	2.1e-09	42.2
WP_138945274.1\|1233699_1233930_-	hypothetical protein	NA	NA	NA	NA
WP_168223326.1\|1233926_1234103_-	hypothetical protein	NA	NA	NA	NA
WP_138945275.1\|1234387_1234750_-	hypothetical protein	A0A249XSN8	Mycobacterium_phage	1.9e-20	49.6
WP_138945276.1\|1234746_1235301_-	hypothetical protein	A0A142KB10	Gordonia_phage	5.0e-44	65.6
WP_138945277.1\|1235300_1235609_-	hypothetical protein	A0A1B3B021	Gordonia_phage	1.3e-22	53.8
WP_168223327.1\|1235605_1236493_-	hypothetical protein	A0A1P8VV67	Rathayibacter_phage	3.0e-46	44.8

DBSCAN-SWA_3

2910598 : 2917769

Mycobacterium_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_168223452.1\|2910598_2911792_+	M23 family metallopeptidase	G8I8L5	Mycobacterium_phage	3.6e-15	45.9
WP_064294335.1\|2911879_2912371_-	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	5.5e-34	46.1
WP_138946446.1\|2913568_2914120_+	hypoxanthine phosphoribosyltransferase	A0A1V0SEQ1	Hokovirus	1.8e-09	29.7
WP_079705154.1\|2914274_2916293_+	ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein	G8DDJ2	Micromonas_pusilla_virus	5.3e-107	44.2
WP_138946447.1\|2916298_2916961_+	GTP cyclohydrolase I FolE	E7DN69	Pneumococcus_phage	4.3e-34	44.9
WP_138946448.1\|2916965_2917769_+	dihydropteroate synthase	S4VNV0	Pandoravirus	6.2e-19	32.1

DBSCAN-SWA_4

3746166 : 3756867

Gordonia_phage(33.33%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064295154.1\|3746166_3747444_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	3.3e-131	58.0
WP_138946877.1\|3747516_3749550_-	M3 family metallopeptidase	A0A1V0SID3	Klosneuvirus	8.6e-33	23.0
WP_138946878.1\|3749583_3749838_-	hypothetical protein	NA	NA	NA	NA
WP_064295157.1\|3749837_3750284_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_138946879.1\|3750280_3752878_-\|tRNA	valine--tRNA ligase	A0A2K9KZB8	Tupanvirus	7.9e-156	37.5
WP_138946880.1\|3753010_3753829_+	acyltransferase family protein	A0A166XZF2	Gordonia_phage	8.8e-45	45.1
WP_168223431.1\|3753825_3755214_+	acyltransferase	A0A166XZF2	Gordonia_phage	3.2e-23	29.7
WP_138946882.1\|3755193_3756867_-	dipeptide ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.3e-14	29.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP040750

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection