CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP022682	Staphylococcus aureus strain 78 chromosome, complete genome	7 crisprs	cas3,DEDDh,DinG,csa3,WYL	2	2	10	0
NZ_CP022683	Staphylococcus aureus strain 78 plasmid pPS00085.1A.1, complete sequence	0 crisprs	RT	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022682_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022682_1

526213-526302

Unclear

Consensus_repeat	Method
AGTTGGGGTGTGGGCCCCAACACAGAAGCTG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP022682_1

>merge|NZ_CP022682|1|526213-526302|CRISPRCasFinder
AGTTGGGGTGTGGGCCCCAACACAGAAGCTGACGAAAAGTCAGCTTACGATAAAGTGCAAGTTGGGGTGTGGGCCCCAACATAGAAGCTG

>NZ_CP022682|1|1|526213-526302|CRISPRCasFinder
AGTTGGGGTGTGGGCCCCAACACAGAAGCTG	ACGAAAAGTCAGCTTACGATAAAGTGCA
AGTTGGGGTGTGGGCCCCAACATAGAAGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022682.1\|WP_001176701.1\|521799_523095_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|366502
NZ_CP022682.1\|WP_000148607.1\|526577_527459_+\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|234643
NZ_CP022682.1\|WP_047213187.1\|530943_532431_+\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NZ_CP022682.1\|WP_000649791.1\|513656_514229_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|223271
NZ_CP022682.1\|WP_047213184.1\|527637_528570_+\|cysteine-synthase-A	unknown	unknown	gnl\|CDD\|273465
NZ_CP022682.1\|WP_000799253.1\|544980_546363_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP022682.1\|WP_000034728.1\|546466_547354_+\|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	unknown	unknown	gnl\|CDD\|179769
NZ_CP022682.1\|WP_001790128.1\|530798_530891_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_001167888.1\|523896_525990_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	unknown	unknown	gnl\|CDD\|273520
NZ_CP022682.1\|WP_000613714.1\|529928_530405_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NZ_CP022682.1\|WP_000167928.1\|528785_529589_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NZ_CP022682.1\|WP_000951460.1\|519250_520444_+\|nucleotide-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|226465
NZ_CP022682.1\|WP_000690439.1\|547357_547918_+\|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	unknown	unknown	gnl\|CDD\|237411
NZ_CP022682.1\|WP_001154302.1\|529566_529932_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|238298
NZ_CP022682.1\|WP_000021445.1\|521218_521620_+\|RNA-binding-protein-S1	unknown	unknown	gnl\|CDD\|236305
NZ_CP022682.1\|WP_000792417.1\|520721_521114_+\|septum-formation-initiator-family-protein	unknown	unknown	gnl\|CDD\|225471
NZ_CP022682.1\|WP_001234988.1\|520440_520704_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NZ_CP022682.1\|WP_115288348.1\|523099_523639_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP022682.1\|WP_031927781.1\|517724_519251_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NZ_CP022682.1\|WP_000154242.1\|514228_517735_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118

Protein	Function_ID	Function_description	E-value
NZ_CP022682.1\|WP_001176701.1\|521799_523095_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|366502	pfam01171, ATP_bind_3, PP-loop family. This family of proteins belongs to the PP-loop superfamily.	3.10271e-78
NZ_CP022682.1\|WP_000148607.1\|526577_527459_+\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|234643	PRK00114, hslO, Hsp33 family molecular chaperone HslO.	1.29884e-159
NZ_CP022682.1\|WP_047213187.1\|530943_532431_+\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NZ_CP022682.1\|WP_000649791.1\|513656_514229_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|223271	COG0193, Pth, Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis].	5.81135e-97
NZ_CP022682.1\|WP_047213184.1\|527637_528570_+\|cysteine-synthase-A	gnl\|CDD\|273465	TIGR01139, Cysteine_synthase, cysteine synthase A. This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family].	3.8342e-167
NZ_CP022682.1\|WP_000799253.1\|544980_546363_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.73424e-131
NZ_CP022682.1\|WP_000034728.1\|546466_547354_+\|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	gnl\|CDD\|179769	PRK04180, PRK04180, pyridoxal 5'-phosphate synthase lyase subunit PdxS.	0
NZ_CP022682.1\|WP_001167888.1\|523896_525990_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP022682.1\|WP_000613714.1\|529928_530405_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	9.12434e-73
NZ_CP022682.1\|WP_000167928.1\|528785_529589_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	1.16187e-122
NZ_CP022682.1\|WP_000951460.1\|519250_520444_+\|nucleotide-pyrophosphohydrolase	gnl\|CDD\|226465	COG3956, COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only].	0
NZ_CP022682.1\|WP_000690439.1\|547357_547918_+\|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	gnl\|CDD\|237411	PRK13525, PRK13525, pyridoxal 5'-phosphate synthase glutaminase subunit PdxT.	9.71225e-112
NZ_CP022682.1\|WP_001154302.1\|529566_529932_+\|dihydroneopterin-aldolase	gnl\|CDD\|238298	cd00534, DHNA_DHNTPE, Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is DHNA which catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. Though it is known that DHNTPE catalyzes the epimerization of dihydroneopterin triphosphate to dihydromonapterin triphosphate, the biological role of this enzyme is still unclear. It is hypothesized that it is not an essential protein since a folX knockout in E. coli has a normal phenotype and the fact that folX is not present in H. influenza. In addition both enzymes have been shown to be able to compensate for the other's activity albeit at slower reaction rates. The functional enzyme for both is an octamer of identical subunits. Mammals lack many of the enzymes in the folate pathway including, DHNA and DHNTPE.	1.74147e-48
NZ_CP022682.1\|WP_000021445.1\|521218_521620_+\|RNA-binding-protein-S1	gnl\|CDD\|236305	PRK08582, PRK08582, RNA-binding protein S1.	4.42227e-78
NZ_CP022682.1\|WP_000792417.1\|520721_521114_+\|septum-formation-initiator-family-protein	gnl\|CDD\|225471	COG2919, COG2919, Septum formation initiator [Cell division and chromosome partitioning].	3.2193e-21
NZ_CP022682.1\|WP_001234988.1\|520440_520704_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	2.63429e-32
NZ_CP022682.1\|WP_115288348.1\|523099_523639_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	1.3254e-93
NZ_CP022682.1\|WP_031927781.1\|517724_519251_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	7.21495e-87
NZ_CP022682.1\|WP_000154242.1\|514228_517735_+\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0

>NZ_CP022682.1|WP_001167888.1|523896_525990_+|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein
MQKAFRNVLVIVIIGVIIFGLFSYLNGNGNMPKQLTYNQFTEKLEKGDLKTLEIQPQQNVYMVSGKTKNDEDYSSTILYNNEKELQKITDAAKKQNGVKLTIKEEEKQSVFVSILSTLIPVVVIALLFIFFLSQAQGGGSGGRMMNFGKSKAKMYDNNKRRVRFSDVAGADEEKQELIEIVDFLKDNKKFKEMGSRIPKGVLLVGPPGTGKTLLARAVAGEAGAPFFSISGSDFVEMFVGVGASRVRDLFDNAKKNAPCIIFIDEIDAVGRQRGAGVGGGHDEREQTLNQLLVEMDGFGENEGIIMIAATNRPDILDPALLRPGRFDRQIQVGRPDVKGREAILHVHAKNKPLDETVDLKAISQRTPGFSGADLENLLNEASLIAVREGKKKIDMRDIEEATDRVIAGPAKKSRVISKKERNIVAHHEAGHTIIGMVLDEAEVVHKVTIVPRGQAGGYAMMLPKQDRFLMTEQELLDKICGLLGGRVSEDINFNEVSTGASNDFERATQIARSMVTQYGMSKKLGPLQFGHSNGQVFLGKDMQGEPNYSSQIAYEIDKEVQRIVKEQYERCKQILLEHKEQLILIAETLLTEETLVAEQIQSLFYEGKLPEIDYDAAKVVKDEDSEFNDGKFGKSYEEIRKEQLEDGQRDESEDRKEEKDIAEDKKEADKSDEKDEPAHRQAPNIEKPYDPNHPDNK
>NZ_CP022682.1|WP_115288348.1|523099_523639_+|hypoxanthine-phosphoribosyltransferase
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRRVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYRELYRNLPYIGTLKPEVYSN
>NZ_CP022682.1|WP_001176701.1|521799_523095_+|tRNA-lysidine(34)-synthetase-TilS
MQLNSNGWHVDDHIVVAVSTGIDSMCLLYQLLKDYKDSYRKLTCLHVNHGVRSASIEEARFLEAYCERHHIDLHIKKLDLSHSLNRNNSIQNEARIKRYEWFDEMMNVLEADVLLTAHHLDDQLETIMYRIFNGKSTRNKLGFDELSKRKGYQIYRPLLAVSKKEIKQFQERYHIPYFEDESNKDNKYVRNDIRNRIIPAIDENNQLKVSHLLKLKQWHDEQYDILQYSAKQFIQEFVKFDEQSKYLEVSRQSFNDLPNSLKMVVLDCLLSKYYELFNISAKTYEEWFKQFSSKKAQFSINLTDKWIIQIAYGKLIIMAKNNGDTYFRVQTIEKPGNYIFNKYRLEIHSNLPKCLFPLSVRTRQSGDTFKLNGRDGYKKVNRLFIDCKVQQWVRDQMPIVLDKQQRIIAVGDLYQQQTIKQWIIISKNGDE
>NZ_CP022682.1|WP_000021445.1|521218_521620_+|RNA-binding-protein-S1
MSIEVGNKLKGKVTGIKKFGAFVELPEGKSGLVHISEVADNYVENVEEHLSVGDEVDVKVLSIADDGKISLSIKKAKDRPRRQHTSKPSHQKPVQKAEDFEKKLSNFLKDSEDKLTSIKRQTESRRGGKGSRR
>NZ_CP022682.1|WP_000792417.1|520721_521114_+|septum-formation-initiator-family-protein
MKNKVEHIENQYTSQENKKKQRQKMKMRVVRRRITVFAGVLLAIIVVLSILLVVQKHRNDIDAQERKAKEAQFQKQQNEEIALKEKLNNLNDKDYIEKIARDDYYLSNKGEVIFRLPEDKDSSSSKSSKK
>NZ_CP022682.1|WP_001234988.1|520440_520704_+|RNA-binding-S4-domain-containing-protein
MRLDKYLKVSRLIKRRTLAKEVSDQGRITINGNVAKAGSDVKVEDVLTIRFGQKLVTVKVTALNEHASKDNAKGMYEIIEERRLEEA
>NZ_CP022682.1|WP_000951460.1|519250_520444_+|nucleotide-pyrophosphohydrolase
MAHTITIVGLGNYGIDDLPLGIYKFLKTQNKVYARTLDHPVIESLQDELTFQSFDHVYETHDQFEDVYNDIVAQLVEAANEKDIVYAVPGHPRVAETTTVKLLALAKDNTDIDVKVLGGKSFIDDVFEAVNVDPNDGFTLLDATSLQEVTLNVRTHTLITQVYSAMVAANLKITLMERYPDDYPVQIVTGARSDGADNVVTCPLYELDHDENAFNNLTSVFVPKITTPTYLYHDFDFATEVIDTLVDEDKGCPWDKVQTHETLKRYLLEETFELFEAIDNEDDWHMIEELGDILLQVLLHTSIGKKEGYIDIKEVITSLNAKMIRRHPHIFGDANAETIDDLKEIWSKAKDAEGKQPRVKFEKVFAEHFLNLYEKTKDKSFDEAALKQWLEKGESNT
>NZ_CP022682.1|WP_031927781.1|517724_519251_+|polysaccharide-biosynthesis-protein
MKHKEAFNGVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEAYAKAVAYIQLVGILLFIAIFVFANNIAYMMGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIVTIVIFVDRGWTIYEAGTIAILASTIGFLGSSIYLVAHRPFKFKMVNNTAKIVWKQFALSVLIFAISQLIVILWQVIDSVTIIKSLQAIRVPFDVAITEKGVYDRGASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKITILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMMAGLVIKFILNIILIRLSGIIGASISTVVSLIIFGTIIHIAVTRKYHLHAMRRFFINVVLGMVFMSIVVQCVLNIVTTHGRITGLIELLCAAVLGIIALFFYIFRFNVLTYKELTYLPFGSKLYQIKKGRR
>NZ_CP022682.1|WP_000154242.1|514228_517735_+|transcription-repair-coupling-factor
MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFVDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRDFDVETQRSKDNIEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIDYFQKDAIIAVDEFNRIKETEESLTVESDTFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA
>NZ_CP022682.1|WP_000649791.1|513656_514229_+|aminoacyl-tRNA-hydrolase
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDHVMNEFNGEVK
>NZ_CP022682.1|WP_000148607.1|526577_527459_+|Hsp33-family-molecular-chaperone-HslO
MTHDYIVKALAFDGEIRAYAALTTETVQEAQTRHYTWPTASAAMGRTMTATAMMGAMLKGDQKLTVTVDGQGPIGRIIADANAKGEVRAYVDHPQTHFPLNEQGKLDVRRAVGTNGSIMVVKDVGMKDYFSGASPIVSGELGEDFTYYYATSEQTPSSVGLGVLVNPDNTIKAAGGFIIQVMPGAKDETISKLEKAISEMTPVSKLIEQGLTPEGLLNEILGKDHVQILEKMPVQFECNCSHEKFLNAIKGLGEAEIQNMIKEDHGAEAVCHFCGNKYKYTEEELNVLLESLV
>NZ_CP022682.1|WP_047213184.1|527637_528570_+|cysteine-synthase-A
MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLDYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIGLAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGPELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEVVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYDSIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERYLSTPLYSFDD
>NZ_CP022682.1|WP_000167928.1|528785_529589_+|dihydropteroate-synthase
MTKTKIMGILNVTPDSFSDGGKFNNVESAVTRVKAMMDEGADIIDVGGASTRPGHEMISLEEELNRVLPVVEAIVGFDVKISVDTFRSEVAEACLKLGVDIINDQWAGLYDHRMFQVVAKYDAEIVLMHNGNGNRDEPVVEEMLTSLLAQAHQAKIAGISSNKIWLDPGIGFAKTRNEEAEVMARLDELVATEYPVLLATSRKRFTKEMMGYDTTPVERDEVTAATTAYGIMKGVRAVRVHNVELNAKLAKGIDFLKENENARHNLS
>NZ_CP022682.1|WP_001154302.1|529566_529932_+|dihydroneopterin-aldolase
MQDTIFLKGMRFYGYHGALSAENEIGQIFKVDVTLKVDLAEAGRTDNVIDTVHYGEVFEEVKSIMEGKAVNLLEHLAERIANRINSQYNRVMETKVRITKENPPIPGHYDGVGIEIVRENK
>NZ_CP022682.1|WP_000613714.1|529928_530405_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MIQAYLGLGSNIGDRESQLNDAIKILNEYDGINVFNISPIYETAPVGYTEQPNFLNLCVEIQTTLTVLQLLECCLKTEECLHRVRKERWGPRTLDVDILLYGEEMIDLPKLSVPHPRMNERAFVLIPLNDIAANVIEPRSKLKVKDLVFVDDSVKRYK
>NZ_CP022682.1|WP_001790128.1|530798_530891_+|hypothetical-protein
MVNDKVLETSKEMYVEQKCLIFYKTLKENV
>NZ_CP022682.1|WP_047213187.1|530943_532431_+|lysine--tRNA-ligase
MSEEMNDQMLVRRQKLQELYDLGIDPFGSKFDRSGLSSDLKEEWDQYSKEELVEKEADSHVAIAGRLMTKRGKGKAGFAHVQDLAGQIQIYVRKDQVGDDEFDLWKNADLGDIVGVEGVMFKTNTGELSVKAKKFTLLTKSLRPLPDKFHGLQDIEQRYRQRYLDLITNEDSTRTFINRSKIIQEMRNYLNNKGFLEVETPMMHQIAGGAAARPFVTHHNALDATLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYHDIMDLTESMVRHIANEVLGSAKVQYNGETIDLESAWTRLHIVDAVKEATGVDFYEIKSDEEAKALAKEHGIEIKDTMKYGHILNEFFEQKVEETLIQPTFIYGHPTEISPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQKGRFEAQLVEKAQGNDEAHEMDEDYIEALEYGMPPTGGLGIGIDRLVMLLTDSPSIRDVLLFPYMRQK
>NZ_CP022682.1|WP_000799253.1|544980_546363_-|PLP-dependent-aminotransferase-family-protein
MKNTLYHQLYEKLKKQIIEGQFKEGDKFYSKRQLSKHLSISQTTVEHAYQLLLDEGYIYSRPRSGYFVSEIESLTILNNQPIPSLFDDDSYKPKASDEAYDYAFNLDEIDTKHFPIELFRKYSKDLYDTNHLNQLRRGHFQGELHLRFQLAFYLFTNRGVICDPNQIIIGSSTEQLVNQLVDLLYTSTFIIEKPSYPPIKNILDKKQVEYEQIEVEDNGINVDEVIKSQKNIVYITPSHQFPTGYVMDLKKRTQLIQWAQEKEERFIIEDDYDSEFRYFGKPIPAIQGLYSRGEKVIYISTFSKSIFPSCRVAYMVLPYSIMKKYHSQNHIEGNTVPVHMQNLIATFISSGGFERHLNKMRRIYRRKLTYILNRLKPYKEQLDIQGAETGMHFTITVKNGLTLQECLDRANKVKLKLQVYNFDDDQDYKKTPKFILGFGGIDDDALKPHVDALIKSLIIK
>NZ_CP022682.1|WP_000034728.1|546466_547354_+|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS
MSKIIGSDRVKRGMAEMQKGGVIMDVVNAEQARIAEEAGAVAVMALERVPSDIRAAGGVARMANPKIVEEVMNAVSIPVMAKARIGHITEARVLEAMGVDYIDESEVLTPADEEYHLRKDQFTVPFVCGCRNLGEAARRIGEGAAMLRTKGEPGTGNIVEAVRHMRQVNSEVSRLTVMNDDEIMTFAKDIGAPYEILKQIKDNGRLPVVNFAAGGVATPQDAALMMELGADGVFVGSGIFKSEDPEKFAKAIVQATTHYQDYELIGRLASELGTAMKGLDINQLSLEERMQERGW
>NZ_CP022682.1|WP_000690439.1|547357_547918_+|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT
MKIGVLALQGAVREHIRHIELSGHEGIAVKKVEQLEEIEGLILPGGESTTLRRLMNLYGFKEALQNSTLPMFGTCAGLIVLAQDIVGEEGYLNKLNITVQRNSFGRQVDSFETELDIKGIATDIEGVFIRAPHIEKVGQGVDILCKVNEKIVAVQQGKYLGVSFHPELTDDYRVTDYFINHIVKKA

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Crispr_ID: NZ_CP022682_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022682_2

1042680-1042776

Orphan

Consensus_repeat	Method
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022682_2

>merge|NZ_CP022682|2|1042680-1042776|CRISPRCasFinder
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGGTAAAAGAGGGATACTTGCGCTGAGCGCATGCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG

>NZ_CP022682|2|2|1042680-1042776|CRISPRCasFinder
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG	TAAAAGAGGGATACTTGCGCTGAGCGCAT
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022682.1\|WP_000032747.1\|1031141_1033331_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	unknown	unknown	gnl\|CDD\|234921
NZ_CP022682.1\|WP_000064214.1\|1042785_1042920_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_000514290.1\|1051910_1052573_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NZ_CP022682.1\|WP_000437472.1\|1046746_1047013_+\|phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
NZ_CP022682.1\|WP_000505962.1\|1046050_1046593_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368297
NZ_CP022682.1\|WP_001289618.1\|1048969_1049203_-\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|239274
NZ_CP022682.1\|WP_000921977.1\|1040210_1041611_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP022682.1\|WP_000009069.1\|1043071_1044367_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_000666799.1\|1030477_1031149_+\|phosphoribosylformylglycinamidine-synthase-I	unknown	unknown	gnl\|CDD\|235140
NZ_CP022682.1\|WP_031927753.1\|1035817_1036384_+\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|223376
NZ_CP022682.1\|WP_031927754.1\|1037898_1039146_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|237507
NZ_CP022682.1\|WP_000638453.1\|1050758_1051778_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224213
NZ_CP022682.1\|WP_000273259.1\|1039411_1040218_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NZ_CP022682.1\|WP_000483713.1\|1033309_1034794_+\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235984
NZ_CP022682.1\|WP_000033477.1\|1041626_1042202_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|227065
NZ_CP022682.1\|WP_000709282.1\|1036398_1037877_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_CP022682.1\|WP_000030808.1\|1034786_1035815_+\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NZ_CP022682.1\|WP_115288377.1\|1049400_1050762_+\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NZ_CP022682.1\|WP_031927757.1\|1047015_1048734_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NZ_CP022682.1\|WP_115288376.1\|1044791_1045997_+\|class-I-SAM-dependent-rRNA-methyltransferase	unknown	unknown	gnl\|CDD\|224017

Protein	Function_ID	Function_description	E-value
NZ_CP022682.1\|WP_000032747.1\|1031141_1033331_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	gnl\|CDD\|234921	PRK01213, PRK01213, phosphoribosylformylglycinamidine synthase subunit PurL.	0
NZ_CP022682.1\|WP_000514290.1\|1051910_1052573_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	4.35421e-66
NZ_CP022682.1\|WP_000437472.1\|1046746_1047013_+\|phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	2.44795e-51
NZ_CP022682.1\|WP_000505962.1\|1046050_1046593_+\|hypothetical-protein	gnl\|CDD\|368297	pfam05128, DUF697, Domain of unknown function (DUF697). Family of bacterial hypothetical proteins that is sometimes associated with GTPase domains.	0.00760449
NZ_CP022682.1\|WP_001289618.1\|1048969_1049203_-\|glutaredoxin-family-protein	gnl\|CDD\|239274	cd02976, NrdH, NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase activity that is dependent on TRX reductase, not glutathione (GSH). It is part of the NrdHIEF operon, where NrdEF codes for class Ib ribonucleotide reductase (RNR-Ib), an efficient enzyme at low oxygen levels. Under these conditions when GSH is mostly conjugated to spermidine, NrdH can still function and act as a hydrogen donor for RNR-Ib. It has been suggested that the NrdHEF system may be the oldest RNR reducing system, capable of functioning in a microaerophilic environment, where GSH was not yet available. NrdH from Corynebacterium ammoniagenes can form domain-swapped dimers, although it is unknown if this happens in vivo. Domain-swapped dimerization, which results in the blocking of the TRX reductase binding site, could be a mechanism for regulating the oxidation state of the protein.	1.21197e-16
NZ_CP022682.1\|WP_000921977.1\|1040210_1041611_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	9.64258e-65
NZ_CP022682.1\|WP_000638453.1\|1050758_1051778_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|224213	COG1294, AppB, Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion].	1.67944e-76
NZ_CP022682.1\|WP_000666799.1\|1030477_1031149_+\|phosphoribosylformylglycinamidine-synthase-I	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	1.77638e-140
NZ_CP022682.1\|WP_031927753.1\|1035817_1036384_+\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|223376	COG0299, PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism].	1.64347e-91
NZ_CP022682.1\|WP_031927754.1\|1037898_1039146_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|237507	PRK13790, PRK13790, phosphoribosylamine--glycine ligase; Provisional.	0
NZ_CP022682.1\|WP_000273259.1\|1039411_1040218_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	1.09792e-29
NZ_CP022682.1\|WP_000483713.1\|1033309_1034794_+\|amidophosphoribosyltransferase	gnl\|CDD\|235984	PRK07272, PRK07272, amidophosphoribosyltransferase; Provisional.	0
NZ_CP022682.1\|WP_000033477.1\|1041626_1042202_-\|ECF-transporter-S-component	gnl\|CDD\|227065	COG4721, COG4721, ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism].	4.34592e-70
NZ_CP022682.1\|WP_000709282.1\|1036398_1037877_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_CP022682.1\|WP_000030808.1\|1034786_1035815_+\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	0
NZ_CP022682.1\|WP_115288377.1\|1049400_1050762_+\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	8.59307e-165
NZ_CP022682.1\|WP_031927757.1\|1047015_1048734_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NZ_CP022682.1\|WP_115288376.1\|1044791_1045997_+\|class-I-SAM-dependent-rRNA-methyltransferase	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	2.04466e-145

>NZ_CP022682.1|WP_000033477.1|1041626_1042202_-|ECF-transporter-S-component
MSKGLKLSEILVTVLISVVFAVIYNLWWFVYNGVQATGLHLEQLTNGVWFMAAIVCYLIIPKPGIALLAEFAAGAGETIIMGRFDIPTIVYAFIQGLACELVFAIFKYQSRSVMVAMLAGFCTAIAAFPIDYFYGYLNEVAGWNLTLFIVFRLISGAVVAGVLSYLLVKALDKTGVTKLFRPAAKEDYDNL
>NZ_CP022682.1|WP_000921977.1|1040210_1041611_-|ABC-transporter-ATP-binding-protein
MLKVSDLRLKYPSGQRKIFDHLNITIQDKEKVLLLGPSGCGKSTLLNVLSGIVPNLIELPMKYDELIVDPLSGVIFQDPDSQFCMPKVYEELAFVLENRQVPREDMDALIINALNMVNLNVTPETYIKDLSGGMKQKLAIVETILQQSKTLFLDEPTAMLDVQATEDLWTKLIELWENQTVVIVEHKVKHIWNHVDRVILMDYNGNIIADECPEIILQKYVHLLSEYGVWHPRAWEFAPSRVDFPTANSHLLQFKNGRIIRGKSTLLSFSDLEIGLGEWITITGANGSGKTTLLESIMQLIKYQGDVYFENQRLTKIKHAAKHMYLVYQNPELQFITNSVYDEINIHFNHLSKDQSDDETMQLLKLLDLENVKDQHPYELSIGQKRRLSVATALSSKADIIFLDEPTFGLDSHNTFQLIKLFQKRINLGQSIVMVTHDDEIIERYPSRRLKISDGALLDCDGDTNV
>NZ_CP022682.1|WP_000273259.1|1039411_1040218_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MYEQWKVRQSFVDDVNIITKLFLGIILFFFIIFVHNFDFMLYITILMLVFLLMFNGTQFKITAIFITISIGFALLSSLFMILYGNGSHTILKFGFIHITTESLVRGLHVSLRTIAISFFGILIALTSQVVMIFYSLMQHLKVKSKVAYAFMAAIRMIPLMISSLIQLRRSLKMRYQMIDASNYRGLKRFKHLIIPLLSQNIRKAHQLSVAMESKGFRDGPRTYYYNVPFSYKDVIFIIVLIAIITLAYYCSINLPITGIDDVRLGRVG
>NZ_CP022682.1|WP_031927754.1|1037898_1039146_+|phosphoribosylamine--glycine-ligase
MNVLVIGAGGREHALAYKLNQSNLVKQVFVIPGNEAMTPIAEVHTEISESDHQGILDFAKQQDVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMEKYNIPTADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFVNGDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDGPKVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVSGLKKQGDTFVTSGGRVILAIGKGDNVHDAQRDAYEKVSQIQSDHLFYRHDIANKALQLK
>NZ_CP022682.1|WP_000709282.1|1036398_1037877_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MKKAILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGRVKTLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQQTVANPDVTMDEAIENIDIGGPTMLRAAAKNYKHVTTIVHPADYQEVLTRLRNDSLDESYRQSLMIKVFEHTAEYDEAIVRFFKGDKETLRYGENPQQSAYFVRTSNAKHTIAGAKQLHGKQLSYNNIKDADATLALVKKFDTPAAVAVKHMNPCGVGIGDTIEQAFQHAYEADSQSIFGGIVALNRAVTPELAEQLHSIFLEVIIAPKFTDEALDILKQKKNVRLLEIDMTIDSNEEEFVSVSGGYLVQDKDNYVVPKEEMKVVTEVAPTDEQWEAMLLGWKVVPSVKSNAIILSNNKQTVGIGAGQMNRVGAAKIALERAIEINDHVALVSDGFFPMGDTVELAAQHGIKAIIQPGGSIKDQDSIDMANKHGIAMVVTGTRHFKH
>NZ_CP022682.1|WP_031927753.1|1035817_1036384_+|phosphoribosylglycinamide-formyltransferase
MVKIAIFASGSGSNFENIVEHVESGKLENIEVTALYTDHQNAFCIDRAKKHDIPVYINEPKKFDSKAAYEQHLVTLLNEDKVEWIILAGYMRLIGPDLLASFEGKILNIHPSLLPKYKGIDAIGQAYHSGDTITGSTVHYVDSGMDTGEIIEQRQCDIRPDDSKEQLEEKVKKLEYELYPSVIAKIVK
>NZ_CP022682.1|WP_000030808.1|1034786_1035815_+|phosphoribosylformylglycinamidine-cyclo-ligase
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSIGIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAVEKDDYVDGSEVEEGQVVIGLASSGIHSNGYSLVRKLINESGIELASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKAMNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDVSRALKILAEQNVEAYQIGHIVKNESTAIELLGV
>NZ_CP022682.1|WP_000483713.1|1033309_1034794_+|amidophosphoribosyltransferase
MFNYSGLNEECGVFGIWNHPEAAQLTYMGLHSLQHRGQEGAGIVVSDQNELKGERGLGLLTEAIKDDQMERLKGYQHAIGHVRYATSGNKGIENIQPFLYHFYDMSVGICHNGNLINAKSLRQNLEKQGAIFHSSSDTEVIMHLIRRSKAPTFEEALKESLRKVKGGFTFAILTKDALYGAVDPNAIRPLVVGKMKDGTYILASETCAIDVLGAEFVQDIHAGEYVVINDKGITVKSYTHHTTTAISAMEYIYFARPDSTIAGKNVHAVRKASGKKLAQESPVNADMVIGVPNSSLSAASGYAEEIGLPYEMGLVKNQYVARTFIQPTQELREQGVRVKLSAVKDIVDGKNIILVDDSIVRGTTIRRIVKMLKDSGANKVHVRIASPEFMFPSFYGIDVSTTAELISASKSPEEIKDYIGADSLAYLSVDGLIESIGLDYDAPYSGLCVESFTGDYPAGLYDYEANYKAHLSHRQKQYISKNKHFFDSEGNLNV
>NZ_CP022682.1|WP_000032747.1|1031141_1033331_+|phosphoribosylformylglycinamidine-synthase-subunit-PurL
MSKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHSKPFLKQFPTSGEHVLMGPGEGAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSLRFGELDNKQNQRLLKGVVKGIGGYGNCIGIPTTAGEIEFDERYDGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESKRPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQVPTREPGISPYEMMLSETQERMLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLTYDDEVYADIPVEPLADEAPVYILEGEEKNYNTSKNDYTHIDVKDTFFKLLKHPTIASKHYLYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAYRNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNETKGTSIFPTPVVGMVGLIENVNYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHEFESLDLSSEVEKGESIKTAIREGVLSHVQTVGKGGLLITLAKLSAHYGLGLKSSIDITNAQLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGAIAQCLTTQD
>NZ_CP022682.1|WP_000666799.1|1030477_1031149_+|phosphoribosylformylglycinamidine-synthase-I
MKFAVLVFPGSNCDRDMFNAAIKSGVEAEYVDYRETSLSGFDGVLIPGGFSFGDYLRSGAMASVAPIISEVKRLAAEGKPVLGVCNGFQILTEIGLLPGALLHNDSHLFISRNEELEIVNNQTAFTNLYEQGEKVIYPVAHGEGHYYCTDEIYQQLKANNQIILKYVNNPNGSYDDIAGIVNEKGNVCGMMPHPERALETLLGTDSGVKLFEAMVKSWREQHV
>NZ_CP022682.1|WP_000064214.1|1042785_1042920_-|hypothetical-protein
MSNENQNKKAAEKAKEVEEKLKDKKEEKTEDINQTKQDIQDTLN
>NZ_CP022682.1|WP_000009069.1|1043071_1044367_+|hypothetical-protein
MSFLRKHAEIIFSYLIGIVSLFTGLIILINLPLIKQLNGGKKVDTHVHNVWEFLNAFFSEIIKVMSRFIGNFPIVSAIVIIIFGILVMLIGHTLLRTIKYDYDISIFFLVIGIMYFIITLILMTQVYGFFAVIFIIPFTIHIGYIVYKDELNQENVKNHFMWIIVSYGISYLITQIALYGRIDANEIESIDILSVNAFFIIMWLLGQMAIWNFLFLRRALPLTKQELGEEEPELSRTSKGNVTNQTKIHLKQLQDKTTEYARKTRRSVDLDKIRAKRDKFKKKVNDIIDIQEDDIPDWMRKPKWVKPMYVELFCGVVIFLFTFLEFNNRNALFVSGDWKLSQTQYVIEWVTLLILLFIIIAYIATTLTFHLKGKFYYLQLFMGSILFFKLLTEFINIMIHGLLLSVFITPTLLLMLLAIIISYSLQLRERP
>NZ_CP022682.1|WP_115288376.1|1044791_1045997_+|class-I-SAM-dependent-rRNA-methyltransferase
MKIATLNKGKETKYFNGYPLIEEEDIYSQDHLKEEDIYSQDHLKEGDIFQIVTDKSQFVATAYVGRQHKGLGWVLTYDKAQEINTAFFVKLFKTALAERDYYFNIDGTNAFRLFNAEGDGVGGLTIDNYDGHLLIQWYSKGIYKFKYAILEAVRKVFDYKSIYEKVRFKDSEYSGGFVEGDAPEFPIVIEENFTFYNVDLEDGLMTGIFLDQKEVRKKLRDQYAKERHVLNLFSYTGAFSVIAASEASSTTSVDLANRSRSLTEENFGLNAIDPKSQYIYVMDTFDFYKYAARHGHSYDTIVIDPPSFARNKKRTFSVQKDYDKLINGALNILSSEGTLLLCTNASVYPLKQFKNTIKKTLEESGVDYELTEVMGLPKDFKTHPHYKPSKYLKAVFVNIRH
>NZ_CP022682.1|WP_000505962.1|1046050_1046593_+|hypothetical-protein
MGFKNNLTSNLTNKIGNSVFKIENINEKGAMPTTIKELNERRQRAEAIVKRKSLMSSTMSVVPIPGLDFGVDLKLMKDIIEDVNKIYGLDHKQVNSLGDDVKERVMSAAAIQGSQFIGKRISSAFLKIVIRDVAKRTAAKQTKWFPVVGQAVSASISYYFMNKIGKDHIQKCENVIKNVM
>NZ_CP022682.1|WP_000437472.1|1046746_1047013_+|phosphocarrier-protein-HPr
MEQNSYVIIDETGIHARPATMLVQTASKFDSDIQLEYNGKKVNLKSIMGVMSLGVGKDAEITIYADGSDESDAIQAISDVLSKEGLTK
>NZ_CP022682.1|WP_031927757.1|1047015_1048734_+|phosphoenolpyruvate--protein-phosphotransferase
MSKLIKGIAASDGVAIAKAYLLVEPDLTFDKNEKVTDVEGEVAKFNGAIEASKVELTKIRNNAEVQLGADKAAIFDAHLLVLDDPELIQPIQDKIKNENANAATALTDVTTQFVTIFESMDNEYMKERAADIRDVSKRVLSHILGVELPNPSMIDESVVIVGNDLTPSDTAQLNKEFVQGFATNIGGRTSHSAIMSRSLEIPAIVGTKSITQEVKQGDMIIVDGLNGDVIVNPTEDELIAYQDKRERYFADKKELQKLRDADTVTVDGVHAELAANIGTPNDLPGVIENGAQGIGLYRTEFLYMGRDQMPTEEEQFEAYKEVLEAMNGKRVVVRTLDIGGDKELSYLNLPEEMNPFLGYRAIRLCLAQQDIFRPQLRALLRASVYGKLNIMFPMVATINEFREAKAILLEEKENLKNEGHDISDDIELGIMVEIPATAALADVFAKEVDFFSIGTNDLIQYTLAADRMSERVSYLYQPYNPSILRLVKQVIEASHKEGKWTGMCGEMAGDETAIPLLLGLGLDEFSMSATSILKARRQINGLSKNEMTELANRAVDCATQEEVIELVNNYVK
>NZ_CP022682.1|WP_001289618.1|1048969_1049203_-|glutaredoxin-family-protein
MSEIIVYTQNDCPPCTFVKNYLNEHQIDFEERNINNQQYRNEMIDFDAFSTPFILLNGNPMYHVDLDEINKVLNIQD
>NZ_CP022682.1|WP_115288377.1|1049400_1050762_+|cytochrome-ubiquinol-oxidase-subunit-I
MDTVEISRFLTAMTLAVHIIFATIGVGMPLMFAIAEFLGIRKNDFQYIAMAKRWAKAYTITVAVGVVTGTIIGLQLSLIWPTFMEMGGHVIALPLFMETFAFFFEAIFLSIYLYTWDRFKNKWTHFLISIPVIIGGSFSAFFITSVNSFMNTPAGFELKNGKMVNVQPIEAMFNPSFIVRSFHVITTAGMTMAFVIASIAAFKLLRNRQPKDTVYHKKALKMSMIVGFFSTLLSMLAGDLSAKFLHKFQPEKLAAYEWHFDTSSHAKLLLFGVLDEKTQQVKGAIELPGLLSFLADNSVKTKVQGLNDFPKSLHPPMIVHYFFDLMVTMGILCFVISGVYVLTLMFKKLRKFSTHKWMLYGILLTGPASMLAIEFGWFLTEMGRQPWIVRGYMRVAEAATQAGGITFVTILFGVLYIILMYTCAYVLIRMFKNKPAYEDVNRLAKKQGGEIEK
>NZ_CP022682.1|WP_000638453.1|1050758_1051778_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MIYAFIGITVLWLFLFCYIIIASIDFGAGFFALHSKLTGDEKKINHLISRYLNPVWEVTNVFFVFFFVGFVGFFPESIKYLGTVLLIPGSIALIMISLRNSFYAFENYGQDTKLAWMIMYGVSGLLIPASLSTALTITEGGYINVRNNVIDLDWVQLLLSPFAWSVVFLAIISVLYISSGFLTYYAKKANDEPAYNLTRQWHIFLGPPMIIICLFVFLSLRIQNSEHFYSAVFDYWWMFAISFLFFALASLLTFFKKKHGLAFVFVILQMMFAFFGYGISKLPYLLYPFVKITDAYVNPEMGWTLVIVFILGLLLLLPSLILLLRLFVFDKEYVEGKKS
>NZ_CP022682.1|WP_000514290.1|1051910_1052573_+|TrkA-family-potassium-uptake-protein
MGKEYVVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYSDIATHAVVADTTDEAVMKSLGIRNFDHVIVAIGENIQSSTLTTLILKELGVKKVTAKAQNDYHAKILNKIGADTVVHPERDMGRRIAHNVASASVLDYLELADEHSIVELKATEKMAGQSIIDLDIRAQYGINIIAIKRGKEFIISPNPNINLEIGDILIMIGHDNDLNRFEKNIATR

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Crispr_ID: NZ_CP022682_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022682_3

1764099-1764181

Orphan

Consensus_repeat	Method
TGCAAGTTGGGGTGGGGCCCCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022682_3

>merge|NZ_CP022682|3|1764099-1764181|CRISPRCasFinder
TGCAAGTTGGGGTGGGGCCCCAACACAGAAGGTGACGTAATGTCAACTTACTATAATGTGCAAGTTGGGGTGGGGCCCCAACA

>NZ_CP022682|3|3|1764099-1764181|CRISPRCasFinder
TGCAAGTTGGGGTGGGGCCCCAACA	CAGAAGGTGACGTAATGTCAACTTACTATAATG
TGCAAGTTGGGGTGGGGCCCCAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022682.1\|WP_047213534.1\|1773719_1774490_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_CP022682.1\|WP_000160435.1\|1764224_1765523_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226594
NZ_CP022682.1\|WP_000829167.1\|1749789_1750911_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|184468
NZ_CP022682.1\|WP_000777192.1\|1766528_1767218_-\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
NZ_CP022682.1\|WP_000136257.1\|1773127_1773622_-\|thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055
NZ_CP022682.1\|WP_000634175.1\|1770021_1770522_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP022682.1\|WP_000277602.1\|1765727_1766141_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP022682.1\|WP_000040069.1\|1770767_1771970_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP022682.1\|WP_000689995.1\|1768762_1769881_-\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_CP022682.1\|WP_000058379.1\|1757981_1759211_-\|NAD-dependent-malic-enzyme-4	unknown	unknown	gnl\|CDD\|235976
NZ_CP022682.1\|WP_000883646.1\|1755985_1756930_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NZ_CP022682.1\|WP_000717564.1\|1754748_1755717_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP022682.1\|WP_000840576.1\|1772057_1773005_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|223897
NZ_CP022682.1\|WP_000161654.1\|1767392_1768448_+\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NZ_CP022682.1\|WP_000226939.1\|1759662_1762860_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
NZ_CP022682.1\|WP_000123175.1\|1748472_1749741_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|180792
NZ_CP022682.1\|WP_000818525.1\|1751258_1752620_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP022682.1\|WP_000471571.1\|1756929_1757787_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NZ_CP022682.1\|WP_000626082.1\|1762880_1763822_-\|pApA-hydrolase-Pde2	unknown	unknown	gnl\|CDD\|223691
NZ_CP022682.1\|WP_001232650.1\|1752969_1754727_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784

Protein	Function_ID	Function_description	E-value
NZ_CP022682.1\|WP_047213534.1\|1773719_1774490_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	6.72678e-38
NZ_CP022682.1\|WP_000160435.1\|1764224_1765523_-\|CBS-domain-containing-protein	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
NZ_CP022682.1\|WP_000829167.1\|1749789_1750911_-\|citrate-synthase	gnl\|CDD\|184468	PRK14035, PRK14035, citrate synthase; Provisional.	0
NZ_CP022682.1\|WP_000777192.1\|1766528_1767218_-\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	2.522e-133
NZ_CP022682.1\|WP_000136257.1\|1773127_1773622_-\|thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	5.93419e-100
NZ_CP022682.1\|WP_000634175.1\|1770021_1770522_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.27306e-36
NZ_CP022682.1\|WP_000277602.1\|1765727_1766141_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.00154e-19
NZ_CP022682.1\|WP_000040069.1\|1770767_1771970_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP022682.1\|WP_000689995.1\|1768762_1769881_-\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_CP022682.1\|WP_000058379.1\|1757981_1759211_-\|NAD-dependent-malic-enzyme-4	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NZ_CP022682.1\|WP_000883646.1\|1755985_1756930_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NZ_CP022682.1\|WP_000717564.1\|1754748_1755717_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
NZ_CP022682.1\|WP_000840576.1\|1772057_1773005_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	3.79172e-57
NZ_CP022682.1\|WP_000161654.1\|1767392_1768448_+\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	2.79772e-126
NZ_CP022682.1\|WP_000226939.1\|1759662_1762860_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
NZ_CP022682.1\|WP_000123175.1\|1748472_1749741_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
NZ_CP022682.1\|WP_000818525.1\|1751258_1752620_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_CP022682.1\|WP_000471571.1\|1756929_1757787_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
NZ_CP022682.1\|WP_000626082.1\|1762880_1763822_-\|pApA-hydrolase-Pde2	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	9.95606e-99
NZ_CP022682.1\|WP_001232650.1\|1752969_1754727_-\|pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0

>NZ_CP022682.1|WP_000626082.1|1762880_1763822_-|pApA-hydrolase-Pde2
MISTLNEIMKCIEDNDTIIIHRHVRPDPDAYGSQLGLKYYIQQKFPQKQVFAVGEAESSLSFIGELDNIDDKTYQDALVIVCDTANAPRIDDERYSTGSKLIKIDHHPAVDQYGDINLVNTNASSTSEIIYDLISHFNDEAIVNKDIASVLYLGIVGDTGRFLFNNTSEHTMEIAGKLIGHDIDHNALLNKMMEKDPKMLPFQGYVLQHFELMDDGFCQVKITEDVLEQFGIQPNEASQFVNTIADIKGLKIWVFAVDEGSEIRCRLRSKGQLIINDIAQDFGGGGHPNASGVSVNSWDEFEQLATALRTKLN
>NZ_CP022682.1|WP_000226939.1|1759662_1762860_-|DNA-polymerase-III-subunit-alpha
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVEALAITDTNVLYGFPKFYDACIANNIKPIFGMTIYVTNGLNTIETVVLAKDNNGLKDLYQLSSKIKMNSMENVSFELLQQFSSNLIIIFKNVADEHRDIVQVFDSHEDTYLDHQSVLVQGIKHVWIQNVCYQTRQDADTISALAAIRDNTKLDLIHDQEDFGAHFLTEKEIKQLDINQEYLTQVDVIAQKCNAELKYHQSLLPQYQTPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRRERVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDNQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIPTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVDERYQNGKFKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVTLNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDHRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVVLSFYDETIKQMTTLGYINQKDSMFNNFIQSFNPSDIRLI
>NZ_CP022682.1|WP_000058379.1|1757981_1759211_-|NAD-dependent-malic-enzyme-4
MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGLGNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKETNIPVFHDDQHGTAIVTIAGLVNALRVVNKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSYGMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGARVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVARNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ
>NZ_CP022682.1|WP_000471571.1|1756929_1757787_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYLEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLKRHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNDMRQTLSEILKIHQEVTK
>NZ_CP022682.1|WP_000883646.1|1755985_1756930_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVEQLDSLESLSRDEIANDRFEKFRNIGSYIE
>NZ_CP022682.1|WP_000717564.1|1754748_1755717_-|6-phosphofructokinase
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTVQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
>NZ_CP022682.1|WP_001232650.1|1752969_1754727_-|pyruvate-kinase
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVTNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
>NZ_CP022682.1|WP_000818525.1|1751258_1752620_+|amino-acid-permease
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAFKTQFGHASFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRILIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGKYMGYLIFVFFIFVFGLLFINVDTRRAIYFIPIWFILLAFMYLRYKRIAAKSNK
>NZ_CP022682.1|WP_000829167.1|1749789_1750911_-|citrate-synthase
MAELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEELAHLKGKLNQYMTLNPRVYTHFEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYERAMRIQAKVASLVTAFARVRQDKEPLKPNPDLSYAANFLYMLRGELPTDIEVEAFNKALILHADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVDAYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAEEKGLIPNVDFYSASVYHCMEIPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIGETNRKYIPLEERK
>NZ_CP022682.1|WP_000123175.1|1748472_1749741_-|NADP-dependent-isocitrate-dehydrogenase
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK
>NZ_CP022682.1|WP_000160435.1|1764224_1765523_-|CBS-domain-containing-protein
MTKHEQILDYIESLSIGSKISVRKIAKFLNVSEGTAYRAIKDADKMGMVATIDRVGTVRIEKRNRNEIEHLTFNEIVNIIDGQVLGGNKGITKMVSKFAIGAMELKDILKYIGPKTLLIVGNREDVQIEALKRGTAILITGGFKPSNKVINFANEHDLPVLSSSYDTFLVANIINKALFNQKIRKDILIVQDIMTPLDDLSVLFDTMKIADYKRMANRTGHTRFPVVNESYKLVGIVTSREMINTKDDDEIDKVMTRNPIYVNAMSTVASCAHMMIWEGIELIPVVSSNKKTVGVINRQDVLKSMQLLGRQPQMGETINDQIAKYITMNQDGITVEVSPLLINHYGTVSKAAFVSIIEETIQYEMRKFKKGNVMIENLNIVYIKTVPIESHITVRFGILDVGRNFAKIEVNMHSQNDKVASALVICQMFDEV
>NZ_CP022682.1|WP_000277602.1|1765727_1766141_+|universal-stress-protein
MYKNILLGVDTQLKNEKALKEVSKLAGEGTVVTVLNAISEQDAQASIKAGVHLNKLTEERSKRLEKTRKALEDYGIDYDQIIVRGNAKEELLKHANSGKYEIVVLSNRKAEDKKKFVLGSVSHKVAKRATIPVLIVK
>NZ_CP022682.1|WP_000777192.1|1766528_1767218_-|metal-dependent-hydrolase
MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKNTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF
>NZ_CP022682.1|WP_000161654.1|1767392_1768448_+|aminopeptidase-P-family-protein
MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLISGFNVNSFGDIDLTIKQLRNIKSEDEISKIRKAAELADKCIEIGVSYLKEGVTEREVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGDRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPNKEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISEKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGFEVLTHYEK
>NZ_CP022682.1|WP_000689995.1|1768762_1769881_-|alanine-dehydrogenase
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEDKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>NZ_CP022682.1|WP_000634175.1|1770021_1770522_+|universal-stress-protein
MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
>NZ_CP022682.1|WP_000040069.1|1770767_1771970_-|acetate-kinase
MSKLILAINAGSSSLKFQLIRMPEEELVTKGLVERIGLKDSIFTIEVNGEKVKTVQDIKDHVEAVDIMLDAFKAHNIINDINDIDGTGHRVVHGGEKFPESVAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLLRGKEGFINYPHSPVKVVVIPTDEESMIARDVMTFGGLK
>NZ_CP022682.1|WP_000840576.1|1772057_1773005_-|class-I-SAM-dependent-methyltransferase
MAEQQTIMERLFHTLDEKAKTLNNENGQSFIENLGLAMEQVYTNERGLLEQSTLQDRRKAFQFAYLSLMQEEKIQANHQITPDSIGLILGFLVERFMNNQEELHIVDIASGAGHLSATVKEVLPEIAVMHHLIEVDPVLSRVSVHLANFLEIPFDVYPQDAIMPLPLEEADIVIGDFPVGYYPIDERSKEFKLGFEEGHSYSHYLLIEQAINALKDAGYAFLVVPSNIFTGEHVKQLEKYIATETEMQAFLNLPPTLFKNEKARKSILILQKKKSGETKPVEVLLANIPDFKNPSQFQGFMTELNQWMDTNRPKK
>NZ_CP022682.1|WP_000136257.1|1773127_1773622_-|thiol-peroxidase
MTEITFKGGPIHLKGQQINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSEASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
>NZ_CP022682.1|WP_047213534.1|1773719_1774490_-|TSUP-family-transporter
MDLNLTMIIIIILFGFIAAFIDSVVGGGGLISTPALLAIGLPPSVALGTNKLASSFGSLTSTIKFIRSGKVDLYVVAKLFGFVFLASACGAYIATMVPSQILKPLIIIALSSVFIFTLLKKDWGNTRTFTQFTFKKAILFAALFILIGFYDGFVGGGTGSFMLFVLLVFGFDFLSAAGNAKVLNFASNIGALVLFMVLGQVDYVIGLIMASSMIAGSYTGAHFAIKQGVGYVKVLFIIITAILILKNAFDYIQQFL

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP022682_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022682_4

2090071-2090150

Orphan

Consensus_repeat	Method
GGCCCCACCCCAACTTACATTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022682_4

>merge|NZ_CP022682|4|2090071-2090150|CRISPRCasFinder
GGCCCCACCCCAACTTACATTGTTTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCACCCCAACTTGCATTGT

>NZ_CP022682|4|4|2090071-2090150|CRISPRCasFinder
GGCCCCACCCCAACTTACATTGT	TTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGG
GGCCCCACCCCAACTTGCATTGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022682.1\|WP_000791409.1\|2084372_2085428_-\|bi-component-leukocidin-LukGH-subunit-H	unknown	unknown	gnl\|CDD\|369625
NZ_CP022682.1\|WP_000191459.1\|2080181_2080796_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_000857174.1\|2080903_2081941_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP022682.1\|WP_000867953.1\|2098639_2099425_+\|carbon-nitrogen-family-hydrolase	unknown	unknown	gnl\|CDD\|143607
NZ_CP022682.1\|WP_000201394.1\|2092792_2092972_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_000120321.1\|2096434_2097583_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275319
NZ_CP022682.1\|WP_000206632.1\|2085863_2087087_+\|ArgE/DapE-family-deacylase	unknown	unknown	gnl\|CDD\|181490
NZ_CP022682.1\|WP_000197641.1\|2095666_2096410_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP022682.1\|WP_031918283.1\|2095207_2095492_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NZ_CP022682.1\|WP_031927406.1\|2088456_2089659_-\|5-aminolevulinate-synthase	unknown	unknown	gnl\|CDD\|236370
NZ_CP022682.1\|WP_000694770.1\|2079820_2080003_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_001013104.1\|2080038_2080185_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_000874712.1\|2078986_2079625_+\|LexA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376540
NZ_CP022682.1\|WP_001045081.1\|2090290_2091598_+\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|273349
NZ_CP022682.1\|WP_000240648.1\|2093515_2095132_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP022682.1\|WP_000522380.1\|2097779_2098406_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|226090
NZ_CP022682.1\|WP_047213641.1\|2092169_2092796_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_001108473.1\|2087584_2088454_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP022682.1\|WP_047213639.1\|2083334_2084351_-\|bi-component-leukocidin-LukGH-subunit-G	unknown	unknown	gnl\|CDD\|369625
NZ_CP022682.1\|WP_000046023.1\|2100022_2100103_-\|delta-hemolysin	unknown	unknown	gnl\|CDD\|173213

Protein	Function_ID	Function_description	E-value
NZ_CP022682.1\|WP_000791409.1\|2084372_2085428_-\|bi-component-leukocidin-LukGH-subunit-H	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.31423e-77
NZ_CP022682.1\|WP_000120321.1\|2096434_2097583_-\|hypothetical-protein	gnl\|CDD\|275319	TIGR04526, predic_Ig_block, putative immunoglobulin-blocking virulence protein. Members of this family are putative virulence proteins of Mycoplasma and Ureaplasma species. Members share a region of sequence similarity (see TIGR04524) with protein M, a Mycoplasma genitalium protein that binds a conserved light chain region of IgG and blocks its protective function of antigen-specific binding. The seed alignment for this model includes an N-terminal signal-anchor domain and a proline-rich linker domain, and a C-terminal extension, in addition to the protein M-like domain recognized by TIGR04524. [Cellular processes, Pathogenesis].	1.67862e-06
NZ_CP022682.1\|WP_000240648.1\|2093515_2095132_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP022682.1\|WP_000522380.1\|2097779_2098406_+\|nitroreductase-family-protein	gnl\|CDD\|226090	COG3560, FMR2, Predicted oxidoreductase related to nitroreductase [General function prediction only].	5.0673e-115
NZ_CP022682.1\|WP_000046023.1\|2100022_2100103_-\|delta-hemolysin	gnl\|CDD\|173213	PRK14752, PRK14752, delta-lysin family phenol-soluble modulin.	2.50854e-06
NZ_CP022682.1\|WP_000206632.1\|2085863_2087087_+\|ArgE/DapE-family-deacylase	gnl\|CDD\|181490	PRK08588, PRK08588, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NZ_CP022682.1\|WP_000197641.1\|2095666_2096410_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	2.23687e-11
NZ_CP022682.1\|WP_031918283.1\|2095207_2095492_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	1.20776e-44
NZ_CP022682.1\|WP_031927406.1\|2088456_2089659_-\|5-aminolevulinate-synthase	gnl\|CDD\|236370	PRK09064, PRK09064, 5-aminolevulinate synthase; Validated.	0
NZ_CP022682.1\|WP_047213639.1\|2083334_2084351_-\|bi-component-leukocidin-LukGH-subunit-G	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	7.62134e-98
NZ_CP022682.1\|WP_000874712.1\|2078986_2079625_+\|LexA-family-transcriptional-regulator	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	3.3604e-11
NZ_CP022682.1\|WP_000857174.1\|2080903_2081941_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.6482e-25
NZ_CP022682.1\|WP_001045081.1\|2090290_2091598_+\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	9.80292e-81
NZ_CP022682.1\|WP_001108473.1\|2087584_2088454_-\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.86916e-09
NZ_CP022682.1\|WP_000867953.1\|2098639_2099425_+\|carbon-nitrogen-family-hydrolase	gnl\|CDD\|143607	cd07583, nitrilase_5, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	2.11308e-126

>NZ_CP022682.1|WP_031927406.1|2088456_2089659_-|5-aminolevulinate-synthase
MYKTLFFDKIAELKEKGSYRIFTEINRIANKYPLAKGEDGKEVVVFCSNDYLGMSQNQEVINVMSDALKEYGAGAGGSRNIGGSHKYFKLLENEIAKWHKKDSALVFPTGYSSNDAALQGLLRIFPEMIVFSDSKNHASIINALRSVKNKIEIFEHNNVKHLNELLNQYDINIPKLIVFESVYSMDGDIAPIVEIVELAKEYNSLTFLDEVHAIGMYGEEGRGYSDVVGVQEDIDIIQSTMAKGIGIIGGYITGDQLLIDVIRSYSSGFIFTTALPPVIAAGCLTSIKIVRSNDKLREELQDKTKYLKEKFKENGIEVLKQSKTHILPVIIGDSKKCEEAAKLLLDKFNIYVQAINSPTVEIGTERFRINVTPNHTKEQMDLLVSSIVYVFDFLNIRRSV
>NZ_CP022682.1|WP_001108473.1|2087584_2088454_-|DMT-family-transporter
MNYLMYLFCMFIWGLNFIAVKIQGDSLPLEVALLYRSLIAFSLFGVMFIFIFKKLKLNNTNWFTIIGFGLCNFTISYLLLYYGTFYSSAAIVTLIFSMKAILTPIFISMVFKRKISNRIYIGGGLGVVSVVVILYPDLNSLTNEFIIGVAFALLGTIITSIGDVLSLYNSESKVHPVLSNTIGMLSAVIFLLIYTSFKGYRYSFPLELNFWFGLLYLSILASFLAWFFYLKLINNIGAAESGYMVAMFPAIGGIASVIMGETHLSINLVVGIILACMGAYLALYKPKPS
>NZ_CP022682.1|WP_000206632.1|2085863_2087087_+|ArgE/DapE-family-deacylase
MTTFSEKEKIQLLADIVELQTENNNEIDVCNYLKDLFDKYDIKSEILKVNEHRANIVAEIGNGSPILALSGHMDVVDAGNQDNWTYPPFQLTEKDGKLYGRGTTDMKGGLMALVITLIELKEQNQLPQGTIRLLATAGEEKEQEGAKLLADKGYLDDVDGLIIAEPTGSGIYYAHKGSMSCKVTATGKAVHSSVPFIGDNAIDTLLEFYNQFKEKYSELKKHDTKHELDVAPMFKSLIGKEISEEDANYASGLTAVCSIINGGKQFNSVPDEASLEFNVRPVPEYDNDFIESFFQNIINNVNSNKLSLDIPSNHRPVTSDKNSKLITTIKDVASSYVNKDDIFVSALVGATDASSFLGDNKDNVDLAIFGPGNPLMAHQIDEYIEKDMYLKYIDIFKEASIQYLKEK
>NZ_CP022682.1|WP_000791409.1|2084372_2085428_-|bi-component-leukocidin-LukGH-subunit-H
MKNKKRVLIASSLSCAILLLSAATTQANSAHKDSQDQNKKEHVDKSQQKDKRNVTNKDKNSTVPDDIGKNGKITKRTETVYDEKTNILQNLQFDFIDDPTYDKNVLLVKKQGSIHSNLKFESHKEEKNSNWLKYPSEYHVDFQVKRNPKTEILDQLPKNKISTAKVDSTFSYSSGGKFDSTKGIGRTSSNSYSKTISYNQQNYDTIASGKNNNWHVHWSVIANDLKYGGEVKNRNDELLFYRNTRIATVENPELSFASKYRYPALVRSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDILKNRPGIHYAPPILEKNKDGQRLIVTYEVDWKNKTVKVVDKYSDDNKPYKEG
>NZ_CP022682.1|WP_047213639.1|2083334_2084351_-|bi-component-leukocidin-LukGH-subunit-G
MIKQLYKNITICSLAISTALTVFPATSYAKINSEIKAVSEKNLDGDTKMYTRTATTSDSQKNITQSLQFNFLTESNYDKETVFIKAKGTIGSGLRILEPNGYWNSTLRWPGSYSVSIQNVDDNNNTNVTDFAPKNQDESREVKYTYGYKTGGDFSINRGGLTGNITKESNYSETISYQQPSYRTLLDQSTSHKGVGWKVEAHLINNMGHDHTRQLTNDSDNRTKSEIFSLTRNGNLWAKDNFTPKDKMPVTVSEGFNPEFLAVMSHDKKDKGKSQFVVHYKRSMDEFKIDWNRHGFWGYWSGENHVDKKEEKLSALYEVDWKTHDVKFVKVLNDNEKK
>NZ_CP022682.1|WP_000857174.1|2080903_2081941_+|site-specific-integrase
MKTRCYDGKKWQYEFKHEGKRYRKKGFRTKREANSAGLDKLNELRSGFNIDNYITLAEYFENWIKTYKQPVVKENTYRHYRNALQHIQKHKIGKMELSKINRQVYQKFINDYSKEHAKETIRKTNGAIRSALDDALYDGLIFKNPAYKVNYKAGKPTKSEQEKFISVTEYEILKDHVRKKRTRSSLALFIMICTGCRVSGARNIKIEHINQVKNTIFIDERKTDTSPRYISIAKSDMKHIMDVISTFAISYDGYIFKEAGFIINLQAINNALKSACRVNNIPIITSHALRHTHCSYLLAKGVSIHYISKRLGHKNIAITTSVYSHLLEEKFNEEDKKTTKILESM
>NZ_CP022682.1|WP_000191459.1|2080181_2080796_-|hypothetical-protein
MTQFLGALLLTGVLGYIPYKYLTMIGLVSEKNKIINTPVLLIFSIETCLIWFYTFIIFNNVDLKNLSLLQLLTGLKANIWFLIIFVLTVLVFNPLIVKFIIWLINETRKFMNLDCISLLDKRDKLFNNNGKPVFIVIKDFENRIIEEGELKTYNSAGSDFDLLEVERQDFKVSDLPSNDELYIKHTLVDLKQQIKLDLYLMNEY
>NZ_CP022682.1|WP_001013104.1|2080038_2080185_+|hypothetical-protein
MNGGENFMADKNKKQEATRSNPINKSFEKPGASENLKSTLSEKAKKKD
>NZ_CP022682.1|WP_000694770.1|2079820_2080003_+|hypothetical-protein
MKIKNCKIKKETIVYEVLTSGNQPFTYELPKDLSSHNARKYLEFISQKIDGDKLTKEDSL
>NZ_CP022682.1|WP_000874712.1|2078986_2079625_+|LexA-family-transcriptional-regulator
MAFKNSIKEIRLNNRLSKVEMARKLDVSEGTIRMWESGRTEPRMGMVEKISSLFNVSKGYLLGEIEEIVLPEFDSEIEVPYFGKVSAGNFEEVAIDNEKLKVPPLAFNGRKPSECIALKINGDSMNKILANGSYIIVHDYRKSCDHKLNSNDILVLRLGGEYTVKRVRRTETKLHLDPVSYSDEFKTNSYDLDSIDEIEVIGKVIYNYRIFD
>NZ_CP022682.1|WP_001045081.1|2090290_2091598_+|TrkH-family-potassium-uptake-protein
MNKVHKPLYFYLMLFFSTTIIGALLLYLPFTGKKPISFLDALFIASSAFTVTGLSPVDIGSQFNILGEIVILLLIQIGGLGIVTVTLLTLVFLNRKISMKNRFLIMVTWNIDEPGGVIKLIKHLAIYSLVTELIGMICLCLSFIPKFGIGKGLFLSLFTSVSAFNNAGFALFKNNLIDYSSDPIVIITISILIIFGGIGHFVVIDFINCKKLSKLSLHSKLVLTTTSILIIIGAITFFLLEQFNTMQNMGLVEKIGNSFFQSVTTRTAGFNSIDIASINKSTALMLMLLMFIGGAPLSASGGIKITTFAVAFIFVLNYIRKENNVSVFNKEISDKHIKLSIVTINISFLFISIITFILSIINPNISLIKLLFEVVSAFGTVGLSMNLTTEYHGITKIIIIFVMLCGKVGLLTLLRTFIPPKSPKNYRYTKGQIYL
>NZ_CP022682.1|WP_047213641.1|2092169_2092796_-|hypothetical-protein
MTVKVISLSELLTGDKQEVKRKIPSVLNILNSFETISISGSESAHDVDLFLKNKSIAFDRQNLSRTHLVFSQFKSKQILVGYFTISNKPLVFTKRMLDKISNTLKKKLYQKGKTHSGNDNLIIQGYLIAQIGKNYSEEALATKSINGNDLLTLAYEKVLEGANIFGGSYIWIDYEDVDRLREFYRKFGFTEIKDHTSENNLKMAILKI
>NZ_CP022682.1|WP_000201394.1|2092792_2092972_-|hypothetical-protein
MATISITTDYKFTKKSAQKLIDAMEINENKSNVNKTNIKATKIKSTCEIENLLKDYRSN
>NZ_CP022682.1|WP_000240648.1|2093515_2095132_-|chaperonin-GroEL
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQSNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNVYQKVSEIKAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATNEWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
>NZ_CP022682.1|WP_031918283.1|2095207_2095492_-|co-chaperone-GroES
MLKPIGNRVIIEKKEQEQTTKSGIVLTDSAKEKSNEGVIVAVGTGRLLNDGTRVTPEVKKGDRVVFQQYAGTEVKRDNETYLVLNEEDILAVIE
>NZ_CP022682.1|WP_000197641.1|2095666_2096410_+|CPBP-family-intramembrane-metalloprotease
MTRLWASLLTVIIYILSQFLPLLIVTKLPFVQYSGIELTKAVIYIQLVLFLIAATTIILINLKIKNPTKLELEVKEPKKYIIPWALLGFALVMIYQMVVSIVYTQIFGTQQTSPNTERLIVIARKIPLFIFFVSIVGPLLEEYVFRKVIFGELFNAIKGNRIVAFAIATTVSSLIFALAHNDYKFIPIYFGMGVIFSLAYVWTKRLAVPIIIHMLQNGFVVIFQLLNPEALKKATEQANFIYHIFIP
>NZ_CP022682.1|WP_000120321.1|2096434_2097583_-|hypothetical-protein
MSYHWFKKMLLSTSILILSSSSLGLATHTVEAKDNLNGEKPTTNLNHNVTSPSVNSEINNNETGTPHESNQTGNEGTNSNSRDANPDSNNVKPDSNNQNPSSDSKPDPNNPNPGPNPKPDPDKPKPNPDPDPKPDPDKPKPNPNPKPDPNKPNPNPSPDPNQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGNSQNPTGNDFVSQRFLALANGAYKYNPYILNQINQLGKEFGEVTDEDIYNIIRKQNFSGNAYLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRSFEPHEKDDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNESQRR
>NZ_CP022682.1|WP_000522380.1|2097779_2098406_+|nitroreductase-family-protein
MGLFKKDKKAMTFDNAMEERRSIYNLKDSISISDDELESMIAHAVKHVPSSFNSQSTRIVLLLNDNNNKFWDNTKAILKEVMGENRDFEPTEQKIDNFKHSYGTILFYEDQDVVSGLQEQMPNYYDNFAIWSTQTNAMHQFAIWTALATKGIGASLQHYNPLVDEITSNEFNIPKSWKLIAQMPFGDIREAAGEKTFNPVEDRFVIKK
>NZ_CP022682.1|WP_000867953.1|2098639_2099425_+|carbon-nitrogen-family-hydrolase
MKVQIYQLPIIFGDSSKNETQITQWFEKNMNDEVDVVVLPEMWNNGYDLEHLNEKADNNLGQSFSFIKHLAEKYKVDIVAGSVSNIRNNQIFNTAFSVNKSGQLINEYDKVHLVPMLREHEFLTAGENVAEPFQLSDGTYVTQLICYDLRFPELLRYPARSGAKIAFYVAQWPMSRLQHWHSLLKARAIENNMFVIGTNSTGFDGNTEYAGHSIVINPNGDLVGELNESADILTVDLNLNEVEQQRENIPVFKSIKLDLYK
>NZ_CP022682.1|WP_000046023.1|2100022_2100103_-|delta-hemolysin
MAQDIISTISDLVKWIIDTVNKFTKK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP022682_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022682_5

2218575-2218660

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTTATGCA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP022682_5

>merge|NZ_CP022682|5|2218575-2218660|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTATTTTTCAACTTTAGTTGTTAGGGGCTCTTATGCA

>NZ_CP022682|5|5|2218575-2218660|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCA	TGCGCTTAGCGCAGGCGCTCCTATTTTT
CAACTTTAGTTGTTAGGGGCTCTTATGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022682.1\|WP_000083812.1\|2226476_2228015_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NZ_CP022682.1\|WP_000908193.1\|2222976_2223759_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NZ_CP022682.1\|WP_047213687.1\|2219875_2221003_-\|SAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|366887
NZ_CP022682.1\|WP_031927658.1\|2223990_2225796_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP022682.1\|WP_000160304.1\|2209058_2209769_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_CP022682.1\|WP_000648717.1\|2230627_2231734_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NZ_CP022682.1\|WP_047213683.1\|2213711_2214650_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NZ_CP022682.1\|WP_000370936.1\|2222051_2222909_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP022682.1\|WP_000808822.1\|2213450_2213681_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_001024091.1\|2215084_2215750_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NZ_CP022682.1\|WP_000019731.1\|2216223_2217201_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NZ_CP022682.1\|WP_047213685.1\|2217466_2218558_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_001802298.1\|2219063_2219168_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_115288427.1\|2232052_2239486_-\|DUF1542-domain-containing-protein	unknown	unknown	gnl\|CDD\|275089
NZ_CP022682.1\|WP_000123394.1\|2211403_2212777_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NZ_CP022682.1\|WP_115288426.1\|2215901_2216222_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP022682.1\|WP_001123308.1\|2210532_2210946_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NZ_CP022682.1\|WP_000070865.1\|2209889_2210333_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NZ_CP022682.1\|WP_000927349.1\|2228049_2230182_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP022682.1\|WP_001292149.1\|2230193_2230628_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014

Protein	Function_ID	Function_description	E-value
NZ_CP022682.1\|WP_000083812.1\|2226476_2228015_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NZ_CP022682.1\|WP_000908193.1\|2222976_2223759_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.56485e-106
NZ_CP022682.1\|WP_047213687.1\|2219875_2221003_-\|SAP-domain-containing-protein	gnl\|CDD\|366887	pfam02037, SAP, SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.	5.97077e-06
NZ_CP022682.1\|WP_031927658.1\|2223990_2225796_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP022682.1\|WP_000160304.1\|2209058_2209769_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NZ_CP022682.1\|WP_047213683.1\|2213711_2214650_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	1.46752e-128
NZ_CP022682.1\|WP_000370936.1\|2222051_2222909_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	2.43638e-59
NZ_CP022682.1\|WP_000019731.1\|2216223_2217201_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.21832e-107
NZ_CP022682.1\|WP_000648717.1\|2230627_2231734_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NZ_CP022682.1\|WP_001024091.1\|2215084_2215750_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.86209e-48
NZ_CP022682.1\|WP_115288427.1\|2232052_2239486_-\|DUF1542-domain-containing-protein	gnl\|CDD\|275089	TIGR04263, cell_wall_surface_anchor_family_protein, SasC/Mrp/FmtB intercellular aggregation domain. This domain, about 375 amino acids long on average, occurs only in Staphylococcus and Streptococcus. It occurs as a non-repetitive N-terminal domain of LPXTG-anchored surface proteins, including SasC, Mrp, and FmtB. This region in SasC was shown to be involved in cell aggregation and biofilm formation, which may explain the methicillin resistance seen for Mrp and FmtB.	1.28538e-108
NZ_CP022682.1\|WP_000123394.1\|2211403_2212777_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.92966e-06
NZ_CP022682.1\|WP_115288426.1\|2215901_2216222_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	2.34998e-17
NZ_CP022682.1\|WP_001123308.1\|2210532_2210946_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	2.52292e-44
NZ_CP022682.1\|WP_000070865.1\|2209889_2210333_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	5.87929e-68
NZ_CP022682.1\|WP_000927349.1\|2228049_2230182_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	5.9991e-68
NZ_CP022682.1\|WP_001292149.1\|2230193_2230628_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62

>NZ_CP022682.1|WP_047213685.1|2217466_2218558_+|hypothetical-protein
MFTYFKSALKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQNIVIYSQFGQKPPGDVYLKVIAVLLIAAIVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGIYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKDNKVVTEPKNTKVETDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NZ_CP022682.1|WP_000019731.1|2216223_2217201_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNATATKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>NZ_CP022682.1|WP_115288426.1|2215901_2216222_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIYHANHPKESGL
>NZ_CP022682.1|WP_001024091.1|2215084_2215750_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSIIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFEGKGEIPREDVATVLKEIVTSNHFNHQEFQVISGEQDIKDALTQFENETD
>NZ_CP022682.1|WP_047213683.1|2213711_2214650_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGKSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQRGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYA
>NZ_CP022682.1|WP_000808822.1|2213450_2213681_-|hypothetical-protein
MKQFLYIALVCSVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NZ_CP022682.1|WP_000123394.1|2211403_2212777_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQINAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NZ_CP022682.1|WP_001123308.1|2210532_2210946_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIQLITSLPNRTKLLGIGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NZ_CP022682.1|WP_000070865.1|2209889_2210333_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLEKAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NZ_CP022682.1|WP_000160304.1|2209058_2209769_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NZ_CP022682.1|WP_001802298.1|2219063_2219168_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NZ_CP022682.1|WP_047213687.1|2219875_2221003_-|SAP-domain-containing-protein
MSVNARDLLVLHNNVNRLVGEEIFANKCLANNDVQIMNSIKKLIEAELLTTTNDFEVSIYKKTRPELQSILKSFGIKTTGNKPDLIKRIDDNFHIINNLDLPYVYIPTKKGEEILKKTEYLTSFIYSYKISLERAYYMVENYIDENCDDKVAEIYKFEFQRKYDNGEFDFNHGYNFELNMLIDHYKRDVKDYDNARKYSNFYLYFGLRDFLKKLMSNYSYYDSKGNIDLNEIQNDLNRFINSSASGMYERLIYNENLSNNIMFELFKKDTQDYSDLEEQLIEKFINYVVSYVKKESRSNTLIELSKMLEKGYTIDKEKFKKEDEYLSRYIITDINYLKNLESKIGVAIDSRNGEIHLVLDDDSLDKLIKNQKNRQ
>NZ_CP022682.1|WP_000370936.1|2222051_2222909_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPEDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NZ_CP022682.1|WP_000908193.1|2222976_2223759_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINGGDKWILYGLNGAGKTTLLNILNVYEPPTTGDVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEIRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NZ_CP022682.1|WP_031927658.1|2223990_2225796_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKSEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>NZ_CP022682.1|WP_000083812.1|2226476_2228015_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIVGFKVLAPIMKFIMYILSVAVESLVHAHLLPVVSILVEPAKILFLNNAINHGVFTPLGTDQAAKVGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKTPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NZ_CP022682.1|WP_000927349.1|2228049_2230182_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGEDSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHIETKDIDGNTSFENEQTSNLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLALPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NZ_CP022682.1|WP_001292149.1|2230193_2230628_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>NZ_CP022682.1|WP_000648717.1|2230627_2231734_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFADKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKVFLSEYAKVDDGLADEIIEAYNSLS
>NZ_CP022682.1|WP_115288427.1|2232052_2239486_-|DUF1542-domain-containing-protein
MNLFRQQKFSIRKFNVGIFSALIATVTFISTNPTTASAAEQNQPAQNQPAQPADANTQPNANAGAQANPTAQPAAPANQGQPAAQPANQGGQANPAGGAAQPNTQPAGQGNQADPNNAAQAQPGNQAAPANQAGQGNNQATPNNNATPANQTQPANAPAAAQPAANAQTQDPNASNTGEGSINTTLTFDDPAISTDENRQDPTVTVTDKVNGYSLINNGKIGFVNSELRRSDMFDKNNPQNYQARGNVAALGRVNANDSTDHGNFNGISKTVNVKPDSELIINFTTMQTNSKQGATNLVIKDAKKNTELATVNVAKTGTAHLFKVPTDADRLDLQFIPDNTAVADASRITTNKDGYKYYSFIDNVGLFSGSHLYVKNRDLAPKATNNKEFTINTEIGNNGNFGASLKADQFKYEVTLPQGVTYVNDSLTTTFPNGNEDSTVLKNMTVNYDQNANKVTFTSQGVTTARGTHTKEVLFPDKSLKLSYKVNVANIDTPKNIDFNEKLTYRTASDVVINNAQPEVTLTADPFSVAVEMNKDALQQQVNSQVDNSHYTTASIAEYNKLKQQADNILNEDANHVETANRASQAAIDGLVTKLQAALIDNQAAIAELDAKAQEKVTAAQQSKKVTQDEVAALVTKINNDKNNAIAEINKQTTSQGVTTEKDNGIAVLEQDVITPTVKPQAKQDIIQAVTTRKQQIKKSNASLQDEKDVANDKIGKIETKAIKDIDAATTNAQVEAIKTKAINDINQTALATTAKAAALEEFDEVVQAQIDQAPLNPDTTNEEVAEAIERINAAKVSDVKAIEATTTAQDLERVKNEEISKIENITDSTQTKMDAYNDVKQAATARKAQNATVSNATNEEVAEADAAVEAAQKQGLHDIQVVKSKQEVADTKSKVLDKINAIQTQAKVKPAADTEVENAYNTRKQEIQNSNASTTEEKQAAYTELDTKKQEARTNLDAANTNSDVTTAKDNSIAAINQVQAATTKKSDAKAEIAQKASERKTAIEAMNDSTTEEQQAAKDKVDQAVVTANTDIDNAAANTDVDNAKTTNEATIAAITPDANVKPTAKQAIADKVQAQETAIDAYNGATTEEKAAAKQQVQTEKTTADAAIDGAHSNAEVEAAKNAEIAKIEAIQPATTTKDDAKQAITTKANERKAAIAQTQDITAEEIAAANADVDNAVTQANSNIEAANSQNDVDQAKTTGETSIDQVTPTVNKKATARNEITTILNNKLQAIQATPDATDEEKQAADAEANTENGKANQAISAATTNAQVDEAKANAEVAINAVTPKVVKKQAAKDEIDQLQVAQTSVINNDQNATNEEKEAAIQQLATAVTDAKNNITAATDDNGVDQAKDAGKNSIQSTQPATAVKSNAKNEVDQAVTTQNQAIDNTTGATTEEKNAAKDLVLKAKEKAYQDILNAQTTNDVTQIKDQAVADVQGITADTTIKDVAKDELATKANEQKALIAQTADATTEEKEQANQQVDAQLTQGNQNIENAQSIDDVNTAKDNAIQAIDPIQASTDVKTNARAELLTEMQNKITEILSDNTTTNEEKGKDIEPVRATYEEGLNNINTANTTGDVTTAKDTAVQKVQQLHANPVKKPAGKTALDQAAADRKTQIEQTPNASQQEINDAKQEVDATLNQAKTNVDQSSTNEYVDNAVKEGKAKINAVKTFSEYKKDALAKIEAAYNSKVNEADNSNASTSSEIAEAKQKLAELKQTADQNVNQATSKDDIEVQIHNDLDNINDYTIPTGKKETATTDLYAYADQKKNNISADTNATQDEKQQAIKQVDQNVQTALESINNGVDNGDVDDALTQGKAAIDAIQVDATVKPKANQAIEAKAEDTKESIDHSDQLTAEEKTEALAMIKQITDQAKKGINDATTTAEVEKAKAQGLEAFDNIQIDSTEKQKAIEELETALDQIEAGVNVDADATTEEKEAFTNALEDILSKATEDISDQTTNAEIATVKNSALEQLKAQRINPEVKKNALEAIREVVNKQIEIIKNADASAKEIARTDLGRYFDRFADNLDKTQTNAEVAELQNVTIPAIEAIVPQNDPDANDTNNGTDNNDATANSNANATPENTGQPNVSETTDNGKADASPTTPNNSDAATGETTATSTNNPSTDDANNKPTANNNSSVDASTDNSATGNGTIDKPEVESTNNGTTDKPATETDNVTPAESTTNNNSTTATNENAPTGSTATAPTTASTEAASSADSKDNAFVNDSKQNAEVNNSAESQSTNGMVVQPKSENKAKAEKDGRDSTNQSMVESTTETLPSADITEPKVPSNTSKDKEESTTNQTDAGHLKSETNVASNEVDKSEGNVDTDVSNKPSTSKPSEAKDKATSTEDSQKADMATADTKDNQAAIGATADVNNKATQNDGANASPATVSNGSNSTNQDMLNVTKTEENKANVKSAQQGKVNKPKQQAKTLPDTGMSHNDDLPYAELALGAGMAFLIRRFTKKDQQTEE

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Crispr_ID: NZ_CP022682_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022682_6

2335903-2335991

Orphan

Consensus_repeat	Method
GTTCCCCAACTTGCACATTATTGTATGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022682_6

>merge|NZ_CP022682|6|2335903-2335991|CRISPRCasFinder
GTTCCCCAACTTGCACATTATTGTATGCTGACTTTTGTCAGCTTCTGTGTTGGGGCCCCGTTCCCCAACTTGCACATTATTGTAAGCTG

>NZ_CP022682|6|6|2335903-2335991|CRISPRCasFinder
GTTCCCCAACTTGCACATTATTGTATGCTG	ACTTTTGTCAGCTTCTGTGTTGGGGCCCC
GTTCCCCAACTTGCACATTATTGTAAGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022682.1\|WP_001161080.1\|2326882_2327200_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_000076926.1\|2341357_2342362_-\|molybdopterin-biosynthesis-protein-MoeB	unknown	unknown	gnl\|CDD\|181084
NZ_CP022682.1\|WP_000602951.1\|2338520_2339006_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|224677
NZ_CP022682.1\|WP_000184421.1\|2333928_2335140_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NZ_CP022682.1\|WP_000866967.1\|2337821_2338055_-\|molybdopterin-converting-factor-subunit-1	unknown	unknown	gnl\|CDD\|340452
NZ_CP022682.1\|WP_000051210.1\|2326483_2326648_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_001566779.1\|2332324_2332576_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_031927354.1\|2335717_2335888_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_000951066.1\|2333495_2333936_+\|winged-helix-DNA-binding-protein	unknown	unknown	gnl\|CDD\|197670
NZ_CP022682.1\|WP_000413855.1\|2330670_2331936_-\|lipid-II:glycine-glycyltransferase-FemX	unknown	unknown	gnl\|CDD\|225224
NZ_CP022682.1\|WP_000066900.1\|2335241_2335592_-\|HTH-type-transcriptional-regulator-SarV	unknown	unknown	gnl\|CDD\|130944
NZ_CP022682.1\|WP_000259726.1\|2339002_2340262_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NZ_CP022682.1\|WP_000643988.1\|2337215_2337815_-\|molybdenum-cofactor-guanylyltransferase-MobA	unknown	unknown	gnl\|CDD\|234725
NZ_CP022682.1\|WP_000134534.1\|2340324_2340819_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NZ_CP022682.1\|WP_047212897.1\|2327386_2330554_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP022682.1\|WP_000913013.1\|2342530_2343136_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226628
NZ_CP022682.1\|WP_000808500.1\|2338060_2338507_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|223391
NZ_CP022682.1\|WP_000503814.1\|2340820_2341327_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	unknown	unknown	gnl\|CDD\|223595
NZ_CP022682.1\|WP_000230173.1\|2336173_2337196_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|274250
NZ_CP022682.1\|WP_000600967.1\|2332567_2333332_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|379203

Protein	Function_ID	Function_description	E-value
NZ_CP022682.1\|WP_000600967.1\|2332567_2333332_-\|VOC-family-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	1.50083e-38
NZ_CP022682.1\|WP_000602951.1\|2338520_2339006_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl\|CDD\|224677	COG1763, MobB, Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism].	1.7369e-49
NZ_CP022682.1\|WP_000184421.1\|2333928_2335140_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.81635e-72
NZ_CP022682.1\|WP_000076926.1\|2341357_2342362_-\|molybdopterin-biosynthesis-protein-MoeB	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	1.97922e-131
NZ_CP022682.1\|WP_047212897.1\|2327386_2330554_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP022682.1\|WP_000951066.1\|2333495_2333936_+\|winged-helix-DNA-binding-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.06862e-14
NZ_CP022682.1\|WP_000413855.1\|2330670_2331936_-\|lipid-II:glycine-glycyltransferase-FemX	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	8.95714e-143
NZ_CP022682.1\|WP_000066900.1\|2335241_2335592_-\|HTH-type-transcriptional-regulator-SarV	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.64009e-20
NZ_CP022682.1\|WP_000643988.1\|2337215_2337815_-\|molybdenum-cofactor-guanylyltransferase-MobA	gnl\|CDD\|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	5.68918e-67
NZ_CP022682.1\|WP_000134534.1\|2340324_2340819_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	2.70933e-97
NZ_CP022682.1\|WP_000259726.1\|2339002_2340262_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	9.192e-158
NZ_CP022682.1\|WP_000913013.1\|2342530_2343136_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226628	COG4148, ModC, ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism].	1.84496e-113
NZ_CP022682.1\|WP_000808500.1\|2338060_2338507_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	5.56799e-58
NZ_CP022682.1\|WP_000503814.1\|2340820_2341327_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	1.92933e-64
NZ_CP022682.1\|WP_000230173.1\|2336173_2337196_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.0538e-165
NZ_CP022682.1\|WP_000866967.1\|2337821_2338055_-\|molybdopterin-converting-factor-subunit-1	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	5.99629e-25

>NZ_CP022682.1|WP_031927354.1|2335717_2335888_+|hypothetical-protein
MFRFISFGQLVVYSTTFIPKKDILQLNGMECDTNVKEPLKIYYVVILKSGIEMIFS
>NZ_CP022682.1|WP_000066900.1|2335241_2335592_-|HTH-type-transcriptional-regulator-SarV
MSNKVQRFIEAERELSQLKHWLKTTHKISIEEFVVLFKVYEAEKISGKELRDTLHFEMLWDTSKIDVIIRKIYKKELISKLRSETDERQVFYFYSTSQKKLLDKITKEIEVLSVTN
>NZ_CP022682.1|WP_000184421.1|2333928_2335140_+|MFS-transporter
MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLFIVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAVVTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILGILGLIISLFIKVDFEVTNNKTETNVIDKPSFSIHQFIAKEAIPVAVIMLLIGVTYASILTYLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCLISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPSFLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
>NZ_CP022682.1|WP_000951066.1|2333495_2333936_+|winged-helix-DNA-binding-protein
MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKYQPTTLIEISHRRAIEKPTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNISQDQMQETINVMNQIHEILLKEAHND
>NZ_CP022682.1|WP_000600967.1|2332567_2333332_-|VOC-family-protein
MILKFDHIIHYIDQLDRFSFPGDVIKLHSGGYHHKYGTFNKLGYINENYIELLDVENNEKLKKMAKTIEGGVAFATQIVQEKYEQGFKNICLRTNDIEAVKNKLQSEQVEVVGPIQMERDTHKDGKVKWQLLYIMNQDDDEIKPPFFIQWEESDSMRTKKLQKYFQKQFSIETVIVKSKNRSQTVSNWLKWFDMDIVEENDHYTDLILKNDDIYFRIEDGKVSKYHSVIIKDAQATSPYSIFIRGAIYRFEPLV
>NZ_CP022682.1|WP_001566779.1|2332324_2332576_+|hypothetical-protein
MRTIILSLFIIMNIVAIIMTLSQPLTVNYFSLRVILIFFTFILSIFFILIKSSRLNNILTILSIVLAIIHMGILAHSTYVYLY
>NZ_CP022682.1|WP_000413855.1|2330670_2331936_-|lipid-II:glycine-glycyltransferase-FemX
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEIQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKRK
>NZ_CP022682.1|WP_047212897.1|2327386_2330554_-|efflux-RND-transporter-permease-subunit
MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLTLAGGQGQSQSQSDNKQNSAMSDVNQASPQQNSKASASNNISGMPTAKLGDLADITVGDVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMIEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWIVIILSTLILLATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHADGFKHPGEWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR
>NZ_CP022682.1|WP_001161080.1|2326882_2327200_+|hypothetical-protein
MQFYLILLAILYLIVSFISIFKMEVIFTRILRIIMGVLLLFVLALTTMSFPKENWWVFIVLLLLVGNVEVTGFKMLKKDLKGVNILNLMSLFIFVIYFILTIVLF
>NZ_CP022682.1|WP_000051210.1|2326483_2326648_+|hypothetical-protein
MSLENQLAELKYDYVRLQGDLEKRESLNLDTSALVRQLKDIENEIRNVRAQMQD
>NZ_CP022682.1|WP_000230173.1|2336173_2337196_-|GTP-3',8-cyclase-MoaA
MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
>NZ_CP022682.1|WP_000643988.1|2337215_2337815_-|molybdenum-cofactor-guanylyltransferase-MobA
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
>NZ_CP022682.1|WP_000866967.1|2337821_2338055_-|molybdopterin-converting-factor-subunit-1
MKVLYFAEIKDILQKAQEDIMLEQALTVQQFEDLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
>NZ_CP022682.1|WP_000808500.1|2338060_2338507_-|molybdenum-cofactor-biosynthesis-protein-MoaE
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>NZ_CP022682.1|WP_000602951.1|2338520_2339006_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MILQIVGYKKSGKTTLMRYIVSFLKSHGYTVATIKHHGHGKEDIQLQDSDVDHMKHFEAGADQSIVQGFQYQQTVTRVDNQNLTQIIEKSVTIDTNIVLVEGFKNADFEKVVVYRNEEELQVLQQLSNVCYSINVREHEDFTAFEQWLLNKIKNDCDTQLT
>NZ_CP022682.1|WP_000259726.1|2339002_2340262_-|molybdopterin-molybdotransferase-MoeA
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETTTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQQDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
>NZ_CP022682.1|WP_000134534.1|2340324_2340819_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIYKQISNNTNTKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSGQ
>NZ_CP022682.1|WP_000503814.1|2340820_2341327_-|molybdenum-cofactor-biosynthesis-protein-MoaB
MGEHQNVKLNRTVKAAVLTVSDTRDFDTDKGGQCVRQLLQADDVEVSDAHYTIVKDEKLAITTQVKKWLEEDIDVIITTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPELNHLIHELTK
>NZ_CP022682.1|WP_000076926.1|2341357_2342362_-|molybdopterin-biosynthesis-protein-MoeB
MSQERYSRQILFKQIGEIGQSKINQKCALIIGMGALGTHVAEGLVRAGIAKLIIVDRDYIEFSNLQRQTLFTEEDALKMMPKVVAAKKHLLALRSDVDIDDYIAHVDYYFLETHGQDVDVIIDATDNFETRQLINDFAYKHRIPWIYGGVVQSTYTEAAFIPGKTPCFNCLVPQLPALNLTCDTVGVIQPAVTMATSLQLRDAMKVLTEQPIDTKITYGDIWEGSHYSFGFSKMQRSACTTCGDVPSYPYLNKNEQRYATLCGRDTVQYENASITHDILVQFLKQHQLNYRSNSYMVMFEFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG
>NZ_CP022682.1|WP_000913013.1|2342530_2343136_-|ATP-binding-cassette-domain-containing-protein
MLKINLKYQLKNTLIRININDTEPKIYAVRGPSGIGKTTVLNMIAGLRKADEAIIEVNGQLLTDTAKNVNVKIQQRRIGYLFQDYQLFPNMTVYKNITFMAEPSEHIDQLIQTLNIDHLMKQYPMTLSGGEAQRVSLARALSTKPDLILLDEPFSSLDDTTKDESITLVKRIFNEWQIPIIFVTHSNYEAEQMAHEIITIG

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Crispr_ID: NZ_CP022682_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022682_7

2485629-2485720

Orphan

Consensus_repeat	Method
TGCGTTCCTTTATTTTCTGCGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022682_7

>merge|NZ_CP022682|7|2485629-2485720|CRISPRCasFinder
TGCGTTCCTTTATTTTCTGCGAATTTTATGAGCTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCAACTGCGTTCCTTTATTTTCTGCGAA

>NZ_CP022682|7|7|2485629-2485720|CRISPRCasFinder
TGCGTTCCTTTATTTTCTGCGAA	TTTTATGAGCTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCAAC
TGCGTTCCTTTATTTTCTGCGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022682.1\|WP_000825931.1\|2480783_2481563_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270429
NZ_CP022682.1\|WP_031927725.1\|2494689_2496048_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NZ_CP022682.1\|WP_000792566.1\|2486130_2487441_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|288473
NZ_CP022682.1\|WP_000971544.1\|2492587_2493703_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
NZ_CP022682.1\|WP_000615459.1\|2479355_2480087_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP022682.1\|WP_031927724.1\|2491884_2492577_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342
NZ_CP022682.1\|WP_000479576.1\|2480083_2480803_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP022682.1\|WP_001807148.1\|2485916_2486036_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_000200954.1\|2491406_2491874_-\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|377623
NZ_CP022682.1\|WP_001125208.1\|2483554_2484241_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518
NZ_CP022682.1\|WP_047212943.1\|2489428_2490376_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	unknown	unknown	gnl\|CDD\|369625
NZ_CP022682.1\|WP_001012216.1\|2478008_2479259_+\|FemA/FemB-family-glycyltransferase-FmhA	unknown	unknown	gnl\|CDD\|367067
NZ_CP022682.1\|WP_000594519.1\|2487930_2488860_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	unknown	unknown	gnl\|CDD\|369625
NZ_CP022682.1\|WP_000762708.1\|2483296_2483401_+\|putative-metal-homeostasis-protein	unknown	unknown	unknown
NZ_CP022682.1\|WP_001046645.1\|2493680_2494688_-\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NZ_CP022682.1\|WP_000038972.1\|2481683_2483123_-\|multidrug-efflux-MFS-transporter-MdeA	unknown	unknown	gnl\|CDD\|129794
NZ_CP022682.1\|WP_000162805.1\|2476773_2477373_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565
NZ_CP022682.1\|WP_047212940.1\|2484567_2485434_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP022682.1\|WP_000783428.1\|2490377_2491355_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	unknown	unknown	gnl\|CDD\|273388
NZ_CP022682.1\|WP_000819846.1\|2477391_2477754_-\|DUF4467-domain-containing-protein	unknown	unknown	gnl\|CDD\|291399

Protein	Function_ID	Function_description	E-value
NZ_CP022682.1\|WP_000825931.1\|2480783_2481563_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.35689e-100
NZ_CP022682.1\|WP_031927725.1\|2494689_2496048_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NZ_CP022682.1\|WP_000615459.1\|2479355_2480087_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.20318e-144
NZ_CP022682.1\|WP_031927724.1\|2491884_2492577_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	2.10153e-129
NZ_CP022682.1\|WP_000479576.1\|2480083_2480803_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.98247e-78
NZ_CP022682.1\|WP_000971544.1\|2492587_2493703_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	9.08937e-138
NZ_CP022682.1\|WP_000200954.1\|2491406_2491874_-\|QueT-transporter-family-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.00118414
NZ_CP022682.1\|WP_001125208.1\|2483554_2484241_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167
NZ_CP022682.1\|WP_047212943.1\|2489428_2490376_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.1102e-93
NZ_CP022682.1\|WP_001012216.1\|2478008_2479259_+\|FemA/FemB-family-glycyltransferase-FmhA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0
NZ_CP022682.1\|WP_000594519.1\|2487930_2488860_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.31899e-97
NZ_CP022682.1\|WP_000819846.1\|2477391_2477754_-\|DUF4467-domain-containing-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	3.44071e-31
NZ_CP022682.1\|WP_001046645.1\|2493680_2494688_-\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NZ_CP022682.1\|WP_000038972.1\|2481683_2483123_-\|multidrug-efflux-MFS-transporter-MdeA	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.56422e-92
NZ_CP022682.1\|WP_000792566.1\|2486130_2487441_+\|hypothetical-protein	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	1.01337e-26
NZ_CP022682.1\|WP_047212940.1\|2484567_2485434_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	7.66469e-90
NZ_CP022682.1\|WP_000783428.1\|2490377_2491355_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	5.50766e-128
NZ_CP022682.1\|WP_000162805.1\|2476773_2477373_-\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	6.8825e-31

>NZ_CP022682.1|WP_047212940.1|2484567_2485434_-|cation-transporter
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNALRLFKEDDVVPNAITIIVSLISGLVMLIVFAVNQRLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>NZ_CP022682.1|WP_001125208.1|2483554_2484241_-|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>NZ_CP022682.1|WP_000762708.1|2483296_2483401_+|putative-metal-homeostasis-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>NZ_CP022682.1|WP_000038972.1|2481683_2483123_-|multidrug-efflux-MFS-transporter-MdeA
MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGITIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGIALVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFSPTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
>NZ_CP022682.1|WP_000825931.1|2480783_2481563_-|transporter-substrate-binding-domain-containing-protein
MKRLLFVMIAFVFILAACGNNSSKDKEASKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKEEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSRSAFAFSKKVDDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>NZ_CP022682.1|WP_000479576.1|2480083_2480803_-|amino-acid-ABC-transporter-permease
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>NZ_CP022682.1|WP_000615459.1|2479355_2480087_-|amino-acid-ABC-transporter-ATP-binding-protein
MIQLNNIHKSFNDVEVIKGIDLSVEQGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVYVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKDEARGKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAKEVSNNIVFIHEGMIGEQGAPEEMFNRPKTEELKRFLNVINEE
>NZ_CP022682.1|WP_001012216.1|2478008_2479259_+|FemA/FemB-family-glycyltransferase-FmhA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHKVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKQNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDTLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPLLYKVKTYLNHKRR
>NZ_CP022682.1|WP_000819846.1|2477391_2477754_-|DUF4467-domain-containing-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYNFSDKRVSYKQDFDSRRYYQQHDADYHEENMTN
>NZ_CP022682.1|WP_000162805.1|2476773_2477373_-|DsbA-family-protein
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPYCKELDEKVMPKLRKNYIDDHKVEYQFVNLAFLGKDSIVGSRASHAVLMYAPKSFLDFQKQLFAAQQDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKDNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>NZ_CP022682.1|WP_001807148.1|2485916_2486036_-|hypothetical-protein
MLTNRLTSVNYVKKRLIQNIQRILSKEVLYGEMQWFANK
>NZ_CP022682.1|WP_000792566.1|2486130_2487441_+|hypothetical-protein
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVQKHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYTDKYFKYKGTIDKTVLSVFGNGYKSYIQPLKVEDQKNYVSKSYAQVRNYVTETLNTGKVLYAFYQNPKVVKAAITTAETASSIKNIFSSFTSFFK
>NZ_CP022682.1|WP_000594519.1|2487930_2488860_+|bi-component-gamma-hemolysin-HlgAB-subunit-A
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>NZ_CP022682.1|WP_047212943.1|2489428_2490376_+|bi-component-gamma-hemolysin-HlgCB-subunit-C
MLRNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN
>NZ_CP022682.1|WP_000783428.1|2490377_2491355_+|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B
MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>NZ_CP022682.1|WP_000200954.1|2491406_2491874_-|QueT-transporter-family-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSVLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTLRKRMAVLLR
>NZ_CP022682.1|WP_031927724.1|2491884_2492577_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQKLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDDRIDLHHYISFLESTPKQVVYETV
>NZ_CP022682.1|WP_000971544.1|2492587_2493703_-|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIQKIIISDSVFSTNGDLVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDVDRLFEILHQED
>NZ_CP022682.1|WP_001046645.1|2493680_2494688_-|biotin-synthase-BioB
MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYDTCENKENKNDVSRAN
>NZ_CP022682.1|WP_031927725.1|2494689_2496048_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGSSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGAVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMTAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYDAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRNLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRNCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP022682_4	4.1\|2090094\|34\|NZ_CP022682\|CRISPRCasFinder	2090094-2090127	34	NZ_CP022682.1	813357-813390	0	1.0
NZ_CP022682_4	4.1\|2090094\|34\|NZ_CP022682\|CRISPRCasFinder	2090094-2090127	34	NZ_CP022682.1	857770-857803	0	1.0
NZ_CP022682_1	1.1\|526244\|28\|NZ_CP022682\|CRISPRCasFinder	526244-526271	28	NZ_CP022682.1	641521-641548	1	0.964
NZ_CP022682_1	1.1\|526244\|28\|NZ_CP022682\|CRISPRCasFinder	526244-526271	28	NZ_CP022682.1	813234-813261	1	0.964
NZ_CP022682_1	1.1\|526244\|28\|NZ_CP022682\|CRISPRCasFinder	526244-526271	28	NZ_CP022682.1	1974931-1974958	1	0.964
NZ_CP022682_4	4.1\|2090094\|34\|NZ_CP022682\|CRISPRCasFinder	2090094-2090127	34	NZ_CP022682.1	374711-374744	1	0.971
NZ_CP022682_4	4.1\|2090094\|34\|NZ_CP022682\|CRISPRCasFinder	2090094-2090127	34	NZ_CP022682.1	767245-767278	1	0.971
NZ_CP022682_4	4.1\|2090094\|34\|NZ_CP022682\|CRISPRCasFinder	2090094-2090127	34	NZ_CP022682.1	1124905-1124938	1	0.971
NZ_CP022682_1	1.1\|526244\|28\|NZ_CP022682\|CRISPRCasFinder	526244-526271	28	NZ_CP022682.1	822333-822360	2	0.929
NZ_CP022682_1	1.1\|526244\|28\|NZ_CP022682\|CRISPRCasFinder	526244-526271	28	NZ_CP022682.1	1214824-1214851	2	0.929
NZ_CP022682_4	4.1\|2090094\|34\|NZ_CP022682\|CRISPRCasFinder	2090094-2090127	34	NZ_CP022682.1	861937-861970	2	0.941
NZ_CP022682_4	4.1\|2090094\|34\|NZ_CP022682\|CRISPRCasFinder	2090094-2090127	34	NZ_CP022682.1	1379093-1379126	2	0.941

1. spacer 4.1|2090094|34|NZ_CP022682|CRISPRCasFinder matches to position: 813357-813390, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

2. spacer 4.1|2090094|34|NZ_CP022682|CRISPRCasFinder matches to position: 857770-857803, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

3. spacer 1.1|526244|28|NZ_CP022682|CRISPRCasFinder matches to position: 641521-641548, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

4. spacer 1.1|526244|28|NZ_CP022682|CRISPRCasFinder matches to position: 813234-813261, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

5. spacer 1.1|526244|28|NZ_CP022682|CRISPRCasFinder matches to position: 1974931-1974958, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

6. spacer 4.1|2090094|34|NZ_CP022682|CRISPRCasFinder matches to position: 374711-374744, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctttgttgg	Protospacer
*************************** ******

7. spacer 4.1|2090094|34|NZ_CP022682|CRISPRCasFinder matches to position: 767245-767278, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctttgttgg	Protospacer
*************************** ******

8. spacer 4.1|2090094|34|NZ_CP022682|CRISPRCasFinder matches to position: 1124905-1124938, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattatctgtgttgg	Protospacer
*********************** **********

9. spacer 1.1|526244|28|NZ_CP022682|CRISPRCasFinder matches to position: 822333-822360, mismatch: 2, identity: 0.929

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacaataatgtgca	Protospacer
*****************.**** *****

10. spacer 1.1|526244|28|NZ_CP022682|CRISPRCasFinder matches to position: 1214824-1214851, mismatch: 2, identity: 0.929

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacaataatgtgca	Protospacer
*****************.**** *****

11. spacer 4.1|2090094|34|NZ_CP022682|CRISPRCasFinder matches to position: 861937-861970, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaatcctctatgttgg	Protospacer
**********************.****.******

12. spacer 4.1|2090094|34|NZ_CP022682|CRISPRCasFinder matches to position: 1379093-1379126, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtgggatttcttttcgaaattctctgtgttgg	Protospacer
****.*.***************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP022682_1	1.1\|526244\|28\|NZ_CP022682\|CRISPRCasFinder	526244-526271	28	NC_021536	Synechococcus phage S-IOM18 genomic sequence	159754-159781	5	0.821
NZ_CP022682_1	1.1\|526244\|28\|NZ_CP022682\|CRISPRCasFinder	526244-526271	28	LN846932	Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome	10627-10654	6	0.786
NZ_CP022682_2	2.1\|1042714\|29\|NZ_CP022682\|CRISPRCasFinder	1042714-1042742	29	NZ_CP015322	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence	703321-703349	6	0.793
NZ_CP022682_1	1.1\|526244\|28\|NZ_CP022682\|CRISPRCasFinder	526244-526271	28	NZ_CP015319	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123a	9464-9491	7	0.75

1. spacer 1.1|526244|28|NZ_CP022682|CRISPRCasFinder matches to NC_021536 (Synechococcus phage S-IOM18 genomic sequence) position: , mismatch: 5, identity: 0.821

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaactcaccttacgataaaattta	Protospacer
******* *** ***********.* .*

2. spacer 1.1|526244|28|NZ_CP022682|CRISPRCasFinder matches to LN846932 (Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome) position: , mismatch: 6, identity: 0.786

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaaatcagattacgataaattagt	Protospacer
*******.**** ********** *.

3. spacer 2.1|1042714|29|NZ_CP022682|CRISPRCasFinder matches to NZ_CP015322 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence) position: , mismatch: 6, identity: 0.793

taaaagagggatacttgcgctgagcgcat	CRISPR spacer
gatcaaagggttccttgcgctgagcgcat	Protospacer
 *  *.**** * ****************

4. spacer 1.1|526244|28|NZ_CP022682|CRISPRCasFinder matches to NZ_CP015319 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123a) position: , mismatch: 7, identity: 0.75

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
tcgaaatgtcagcttacgaaaaagcttt	Protospacer
 ***** ************ ****. .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

310292 : 353163

Staphylococcus_phage(85.94%)

plate,holin,terminase,head,integrase,protease,tail,portal,capsid

attL 310182:310199|attR 355365:355382

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
310182:310199	attL	NA	NA	NA	NA
WP_112367435.1\|310292_311498_-\|integrase	site-specific integrase	A7YGM7	Staphylococcus_virus	1.0e-219	98.8
WP_000191466.1\|311623_312238_+	hypothetical protein	A0A2I6PEZ0	Staphylococcus_phage	6.7e-106	100.0
WP_001013104.1\|312234_312381_-	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	1.1e-14	89.6
WP_000705240.1\|312417_312600_-	hypothetical protein	A0A2I6PDR4	Staphylococcus_phage	5.3e-27	100.0
WP_000511090.1\|312670_313402_-	helix-turn-helix transcriptional regulator	S4SVC5	Staphylococcus_phage	1.3e-132	99.2
WP_000213811.1\|313553_313766_+	helix-turn-helix transcriptional regulator	A7TWF1	Staphylococcus_phage	1.6e-30	100.0
WP_000435357.1\|313813_314257_+	hypothetical protein	A7TWF2	Staphylococcus_phage	8.9e-76	100.0
WP_000362644.1\|314461_314674_-	hypothetical protein	D2JGJ1	Staphylococcus_phage	7.6e-33	100.0
WP_001148860.1\|314743_314941_+	hypothetical protein	A7TWF5	Staphylococcus_phage	4.6e-24	100.0
WP_000773059.1\|314927_315308_-	DUF2513 domain-containing protein	Q4ZCQ5	Staphylococcus_virus	5.8e-68	100.0
WP_001025401.1\|315374_315620_+	DUF2829 domain-containing protein	A0A2I6PF15	Staphylococcus_phage	5.1e-41	100.0
WP_001128433.1\|315588_315954_-	hypothetical protein	A0A2I6PF07	Staphylococcus_phage	2.4e-63	100.0
WP_001097552.1\|316008_316224_+	hypothetical protein	A0A2I6PF01	Staphylococcus_phage	1.9e-31	100.0
WP_001124160.1\|316248_316512_+	helix-turn-helix domain-containing protein	A7TWG0	Staphylococcus_phage	5.7e-46	100.0
WP_001285954.1\|316524_316686_+	DUF1270 domain-containing protein	A7TWM3	Staphylococcus_phage	8.6e-21	100.0
WP_000175000.1\|316764_317088_+	hypothetical protein	A0A2I6PDL5	Staphylococcus_phage	1.3e-52	100.0
WP_000985985.1\|317102_317465_+	hypothetical protein	Q4ZCP8	Staphylococcus_virus	1.4e-55	99.2
WP_000762532.1\|317461_318628_+	DUF2800 domain-containing protein	A0A2I6PDL4	Staphylococcus_phage	8.3e-222	100.0
WP_115288336.1\|318653_319211_+	DUF2815 family protein	A0A2K9VBT2	Staphylococcus_phage	2.0e-96	99.5
WP_115288463.1\|319279_321232_+	DNA polymerase	Q4ZCP5	Staphylococcus_virus	0.0e+00	98.9
WP_001164629.1\|321244_321430_+	DUF3113 family protein	A0A2I6PEM8	Staphylococcus_phage	7.0e-27	100.0
WP_000113974.1\|321429_321831_+	PVL family protein	A0A2I6PEL5	Staphylococcus_phage	1.2e-68	100.0
WP_000022738.1\|321830_322085_+	DUF3310 domain-containing protein	Q6R831	Staphylococcus_virus	8.2e-42	97.6
WP_000178883.1\|322084_322333_+	hypothetical protein	A0A2I6PF06	Staphylococcus_phage	3.6e-42	100.0
WP_001566727.1\|322504_322657_+	DUF1024 family protein	Q9G015	Staphylococcus_virus	3.3e-22	100.0
WP_001566726.1\|322653_322938_+	hypothetical protein	Q9G014	Staphylococcus_virus	8.0e-46	98.9
WP_115288337.1\|322930_323185_+	DUF1024 family protein	A7TWH5	Staphylococcus_phage	1.4e-36	91.7
WP_072433467.1\|323147_323342_+	hypothetical protein	M1SVE4	Staphylococcus_phage	1.3e-23	93.4
WP_031927912.1\|323334_323862_+	dUTP pyrophosphatase	A0A2I6PE85	Staphylococcus_phage	3.0e-94	99.4
WP_031823832.1\|323898_324105_+	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	8.4e-21	77.9
WP_031870647.1\|324101_324296_+	hypothetical protein	S4SX95	Staphylococcus_phage	1.9e-27	95.3
WP_001072795.1\|324292_324496_+	hypothetical protein	A0A0N9BAX5	Staphylococcus_phage	5.2e-31	100.0
WP_000608278.1\|324488_324725_+	hypothetical protein	Q4ZDP0	Staphylococcus_virus	2.8e-36	100.0
WP_001799187.1\|324708_325104_+	hypothetical protein	A7TWI1	Staphylococcus_phage	3.3e-66	100.0
WP_000595260.1\|325100_325253_+	transcriptional activator RinB	A7TWI2	Staphylococcus_phage	2.6e-19	100.0
WP_000265258.1\|325320_325521_+	DUF1514 family protein	A0A2I6PF41	Staphylococcus_phage	2.9e-26	100.0
WP_000884844.1\|325572_328020_+	hypothetical protein	R4WAL1	Staphylococcus_phage	0.0e+00	100.0
WP_078092494.1\|328128_328227_-	hypothetical protein	A0A2I6PDP6	Staphylococcus_phage	1.1e-10	96.9
WP_000665203.1\|328360_328651_+	VRR-NUC domain-containing protein	A0A2I6PEN7	Staphylococcus_phage	6.5e-51	100.0
WP_000513699.1\|330007_330445_+	transcriptional regulator	A0A2I6PDC2	Staphylococcus_phage	4.6e-77	100.0
WP_000160689.1\|330601_330916_+	HNH endonuclease	A0A2I6PDC4	Staphylococcus_phage	2.5e-56	100.0
WP_000778932.1\|331044_331350_+\|terminase	terminase	A0A2I6PE27	Staphylococcus_phage	2.9e-49	100.0
WP_000153555.1\|331339_333031_+\|terminase	terminase large subunit	A0A2I6PE44	Staphylococcus_phage	0.0e+00	100.0
WP_001100671.1\|333035_334274_+\|portal	phage portal protein	A0A2K9VBP0	Staphylococcus_phage	2.6e-234	99.8
WP_000061866.1\|334257_335031_+\|protease	Clp protease ClpP	A0A2I6PEQ7	Staphylococcus_phage	2.4e-137	100.0
WP_001142733.1\|335042_336206_+\|capsid	phage major capsid protein	A0A2I6PE62	Staphylococcus_phage	6.1e-217	99.7
WP_000050975.1\|336274_336553_+\|head,tail	phage gp6-like head-tail connector protein	A0A2I6PE36	Staphylococcus_phage	2.1e-46	100.0
WP_000395501.1\|336564_336897_+	hypothetical protein	A0A2I6PDD6	Staphylococcus_phage	6.2e-58	100.0
WP_000110020.1\|336893_337295_+	hypothetical protein	A0A2I6PDD3	Staphylococcus_phage	6.2e-68	100.0
WP_001023802.1\|337295_337691_+	DUF3168 domain-containing protein	A0A2I6PDD8	Staphylococcus_phage	2.6e-66	100.0
WP_000807539.1\|337725_338367_+\|tail	tail protein	A0A2I6PE59	Staphylococcus_phage	2.2e-120	99.5
WP_000169131.1\|338458_338914_+	Ig domain-containing protein	Q9B0D4	Staphylococcus_phage	2.8e-77	100.0
WP_000589165.1\|338971_339322_+	hypothetical protein	A0A2I6PDE6	Staphylococcus_phage	1.1e-55	100.0
WP_000438833.1\|339363_339522_+	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
WP_115288338.1\|339535_345736_+\|tail	phage tail tape measure protein	A0A2I6PF36	Staphylococcus_phage	0.0e+00	98.8
WP_115288339.1\|345735_346560_+\|tail	phage tail family protein	A0A2I6PER3	Staphylococcus_phage	3.5e-158	99.6
WP_000384474.1\|346568_348152_+	peptidase	A0A2I6PEQ5	Staphylococcus_phage	9.3e-309	100.0
WP_000179860.1\|348151_348442_+	hypothetical protein	A0A2I6PF46	Staphylococcus_phage	2.1e-49	100.0
WP_031887117.1\|348457_350368_+	hypothetical protein	U5U4Q1	Staphylococcus_phage	0.0e+00	99.8
WP_000067140.1\|350367_351834_+\|plate	BppU family phage baseplate upper protein	A7TWK6	Staphylococcus_phage	7.6e-257	100.0
WP_001166599.1\|351833_352223_+	DUF2977 domain-containing protein	A0A2I6PER1	Staphylococcus_phage	2.2e-62	100.0
WP_000916020.1\|352215_352380_+	XkdX family protein	A0A2I6PES4	Staphylococcus_phage	4.9e-24	100.0
WP_000466784.1\|352425_352725_+	DUF2951 domain-containing protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
WP_000339144.1\|352860_353163_+\|holin	phage holin	B7T0L0	Staphylococcus_virus	4.1e-48	100.0
355365:355382	attR	NA	NA	NA	NA

DBSCAN-SWA_2

745639 : 753459

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244415.1\|745639_746695_-	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_115288360.1\|746694_747381_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037811.1\|747355_747829_-	DoxX family protein	NA	NA	NA	NA
WP_001093557.1\|748170_748611_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637683.1\|748890_749475_-	hypothetical protein	NA	NA	NA	NA
WP_115288361.1\|749573_750287_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941334.1\|750290_750710_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446721.1\|750711_751380_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.1
WP_000604509.1\|751730_752324_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	1.5e-38	44.0
WP_001217797.1\|752307_753459_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	2.1e-23	36.1

DBSCAN-SWA_3

765431 : 779624

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663031.1\|765431_766490_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	2.3e-21	26.4
WP_000197262.1\|766647_767190_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429016.1\|767795_768713_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	2.1e-07	22.4
WP_000193751.1\|768994_770500_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930020.1\|770839_771340_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.2e-51	70.8
WP_001068497.1\|771359_772226_-	DMT family transporter	NA	NA	NA	NA
WP_000692523.1\|773026_773425_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	4.3e-53	72.7
WP_000855505.1\|773387_775493_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|775610_776582_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000499194.1\|776757_776913_+	hypothetical protein	NA	NA	NA	NA
WP_047213721.1\|776951_777920_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	8.0e-138	79.1
WP_001245577.1\|777909_778866_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000616870.1\|778862_779624_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	5.0e-18	31.6

DBSCAN-SWA_4

1027911 : 1036384

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001807178.1\|1027911_1028394_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	3.4e-20	43.3
WP_115288375.1\|1028380_1029505_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174052.1\|1029508_1030213_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	2.8e-47	42.1
WP_000848351.1\|1030212_1030476_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666799.1\|1030477_1031149_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032747.1\|1031141_1033331_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.8e-140	39.7
WP_000483713.1\|1033309_1034794_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.2e-45	31.7
WP_000030808.1\|1034786_1035815_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	3.8e-61	41.4
WP_031927753.1\|1035817_1036384_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	8.0e-29	40.1

DBSCAN-SWA_5

1275989 : 1329302

Bacillus_phage(27.59%)

tRNA,terminase,head,transposase,protease,tail,portal,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001001521.1\|1275989_1277534_+\|tRNA	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	NA	NA	NA	NA
WP_000282386.1\|1277534_1277900_+	hypothetical protein	NA	NA	NA	NA
WP_000842277.1\|1277926_1278418_+	energy coupling factor transporter S component ThiW	NA	NA	NA	NA
WP_000073332.1\|1278720_1281339_+	DNA mismatch repair protein MutS	E3T5Q7	Cafeteria_roenbergensis_virus	5.0e-41	23.7
WP_000516257.1\|1281351_1283361_+	DNA mismatch repair endonuclease MutL	A0A1B2LRQ5	Wolbachia_phage	5.3e-59	29.5
WP_001077635.1\|1283366_1283909_+	glycerol-3-phosphate responsive antiterminator	NA	NA	NA	NA
WP_001103747.1\|1284383_1285202_+	aquaporin family protein	M1H4F4	Acanthocystis_turfacea_Chlorella_virus	3.1e-26	35.1
WP_000417379.1\|1285330_1286827_+	glycerol kinase GlpK	NA	NA	NA	NA
WP_001218598.1\|1286984_1288658_+	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_000136955.1\|1288807_1289722_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_001798536.1\|1289739_1290675_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_000561359.1\|1290689_1290923_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_001807150.1\|1291185_1292505_-\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
WP_000448078.1\|1292665_1293142_-	glutathione peroxidase	Q70H87	Fowlpox_virus	1.2e-22	38.0
WP_031927515.1\|1293253_1294492_+	GTPase HflX	NA	NA	NA	NA
WP_000652044.1\|1294510_1295749_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000624945.1\|1295991_1296360_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_001126603.1\|1296378_1297719_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_115288387.1\|1299037_1299733_-	hypothetical protein	A0A2H4J5B8	uncultured_Caudovirales_phage	3.4e-05	34.5
WP_000554410.1\|1299744_1300128_-	hypothetical protein	NA	NA	NA	NA
WP_001807150.1\|1300323_1301643_+\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
WP_000664916.1\|1301799_1302192_-	helix-turn-helix domain-containing protein	A0A2I6PE55	Staphylococcus_phage	2.7e-28	53.6
WP_001209962.1\|1302359_1302578_+	DUF739 family protein	A0A2I6PE94	Staphylococcus_phage	4.9e-19	62.5
WP_000932237.1\|1302604_1302880_+	hypothetical protein	NA	NA	NA	NA
WP_000800340.1\|1303303_1303510_-	hypothetical protein	A1BTY8	Staphylococcus_virus	4.3e-25	75.0
WP_001157026.1\|1303569_1304253_+	phage repressor protein	A9CR56	Staphylococcus_phage	8.0e-108	86.0
WP_000072840.1\|1304351_1304513_+	DUF1270 family protein	R4IH12	Staphylococcus_phage	1.1e-12	69.8
WP_031927615.1\|1304600_1304918_+	DUF2482 family protein	W5RAK4	Staphylococcus_phage	9.0e-30	74.5
WP_000786635.1\|1304907_1305174_+	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	3.9e-18	53.6
WP_001002734.1\|1305178_1306429_+	helicase SNF2	A0A1B1P7L4	Bacillus_phage	1.8e-134	57.8
WP_025174483.1\|1306419_1306737_+	hypothetical protein	A0A2P0ZLA7	Lactobacillus_phage	7.1e-19	43.2
WP_000160835.1\|1306729_1307035_+	hypothetical protein	A0A1B1P7M6	Bacillus_phage	5.8e-26	59.3
WP_031927619.1\|1307024_1308851_+	AAA family ATPase	A0A1B1P7N0	Bacillus_phage	2.6e-166	56.3
WP_001250666.1\|1308868_1309075_+	hypothetical protein	NA	NA	NA	NA
WP_000140895.1\|1309120_1309603_+	DUF669 domain-containing protein	A0A2H4J1S8	uncultured_Caudovirales_phage	2.9e-19	37.3
WP_000560476.1\|1309884_1311603_+	hypothetical protein	A0A1B1P7M5	Bacillus_phage	1.9e-211	63.6
WP_000394569.1\|1311706_1312096_+	hypothetical protein	U3PG42	Staphylococcus_phage	4.5e-07	51.9
WP_000792984.1\|1312171_1312477_+	hypothetical protein	A0A2H4JF73	uncultured_Caudovirales_phage	6.2e-36	73.7
WP_000231299.1\|1312499_1312970_-	hypothetical protein	NA	NA	NA	NA
WP_000584491.1\|1313390_1313582_+	hypothetical protein	NA	NA	NA	NA
WP_115288388.1\|1313613_1315419_+	DNA primase	A0A1B1P7L5	Bacillus_phage	1.6e-208	58.8
WP_000933402.1\|1315792_1316284_+	hypothetical protein	S5MAA9	Brevibacillus_phage	7.4e-07	30.0
WP_000870118.1\|1316716_1317007_+	HNH endonuclease	D2XR61	Bacillus_phage	1.3e-19	43.2
WP_000868798.1\|1317325_1317658_+	hypothetical protein	NA	NA	NA	NA
WP_046463075.1\|1317641_1319285_+\|terminase	terminase large subunit	A0A0U4B089	Bacillus_phage	8.4e-180	57.3
WP_000523761.1\|1319300_1320437_+\|portal	phage portal protein	A0A2H4JBZ5	uncultured_Caudovirales_phage	7.8e-84	41.4
WP_115288389.1\|1320436_1321123_+\|protease	Clp protease ClpP	A0A2H4J8Y7	uncultured_Caudovirales_phage	4.0e-43	49.5
WP_115288390.1\|1321149_1322319_+\|capsid	phage major capsid protein	A0A0U4JIF4	Bacillus_phage	1.3e-97	50.3
WP_000406284.1\|1322340_1322646_+	hypothetical protein	A0A059T7R0	Listeria_phage	6.0e-15	44.8
WP_000744618.1\|1322620_1322965_+\|head	phage head closure protein	NA	NA	NA	NA
WP_000114215.1\|1322948_1323287_+	hypothetical protein	NA	NA	NA	NA
WP_000072314.1\|1323286_1323724_+	hypothetical protein	NA	NA	NA	NA
WP_000213868.1\|1323729_1324413_+	hypothetical protein	NA	NA	NA	NA
WP_000021684.1\|1324440_1324791_+	hypothetical protein	NA	NA	NA	NA
WP_000159313.1\|1324838_1325063_+	hypothetical protein	NA	NA	NA	NA
WP_031927625.1\|1325120_1329302_+\|tail	phage tail tape measure protein	Q9T0X1	Lactobacillus_phage	3.2e-58	42.6

DBSCAN-SWA_6

1333490 : 1339936

Staphylococcus_phage(83.33%)

capsid,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000569801.1\|1333490_1333901_+	hypothetical protein	A0A1I9KKA6	Lactobacillus_phage	3.9e-09	32.8
WP_000665466.1\|1333935_1334250_+	hypothetical protein	NA	NA	NA	NA
WP_047213423.1\|1334233_1334617_+\|holin	phage holin family protein	H9A0W5	Staphylococcus_phage	4.3e-18	39.2
WP_031927627.1\|1334681_1335602_+	N-acetylmuramoyl-L-alanine amidase	A0A1W6JQL2	Staphylococcus_phage	1.2e-66	50.2
WP_115288391.1\|1336078_1336276_+	hypothetical protein	A0A1W6JNK0	Staphylococcus_phage	9.9e-11	50.0
WP_001019311.1\|1336469_1336973_+	hypothetical protein	NA	NA	NA	NA
WP_000459699.1\|1336985_1337300_+	hypothetical protein	NA	NA	NA	NA
WP_000907423.1\|1337299_1337728_+	hypothetical protein	NA	NA	NA	NA
WP_000997672.1\|1338131_1338341_+	helix-turn-helix domain-containing protein	A0A1W6JNK0	Staphylococcus_phage	1.9e-12	59.4
WP_115288392.1\|1338595_1339936_+\|capsid	minor capsid protein	A0A1J0MFV1	Staphylococcus_phage	1.2e-139	58.7

DBSCAN-SWA_7

1613790 : 1622102

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1613790_1614576_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924216.1\|1614701_1615592_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_001062177.1\|1615601_1616948_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	2.4e-55	34.0
WP_000683926.1\|1617061_1618162_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	2.3e-08	30.6
WP_000624574.1\|1618164_1618842_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283055.1\|1618972_1620079_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217266.1\|1620302_1622102_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	1.3e-53	36.3

DBSCAN-SWA_8

1691574 : 1700617

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1691574_1692093_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_042908036.1\|1692114_1694388_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	8.1e-64	29.3
WP_115288409.1\|1694590_1696870_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1697144_1697405_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1697423_1698563_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019170.1\|1698585_1699611_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005767.1\|1699612_1700617_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_9

1829451 : 1910486

Staphylococcus_phage(94.12%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_115288412.1\|1829451_1835991_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	8.9e-289	92.1
WP_000836469.1\|1836316_1836628_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	4.5e-50	96.1
WP_162805395.1\|1836649_1839064_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.2
WP_001025061.1\|1839354_1840536_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
WP_000526539.1\|1840645_1841599_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
WP_000764419.1\|1841595_1842159_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
WP_000757543.1\|1842278_1842680_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266089.1\|1843251_1844079_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_072357767.1\|1844081_1844201_-	hypothetical protein	NA	NA	NA	NA
WP_001196354.1\|1844312_1845314_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
WP_001008551.1\|1845435_1845900_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
WP_115288415.1\|1845912_1847094_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	6.6e-227	99.7
WP_000493884.1\|1847104_1847737_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.4e-111	98.6
WP_000384178.1\|1847743_1848775_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	6.9e-196	98.8
WP_001261666.1\|1849267_1850770_-	FAD-dependent oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	8.6e-30	98.6
WP_000221188.1\|1851290_1851605_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	2.8e-52	97.1
WP_111228746.1\|1851604_1852897_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	3.4e-224	97.4
WP_000163240.1\|1852914_1853310_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	2.4e-72	99.2
WP_047212960.1\|1853713_1855033_-\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
WP_001032833.1\|1855179_1856034_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1856309_1856534_-	hypothetical protein	NA	NA	NA	NA
WP_000671048.1\|1856732_1857203_+	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	4.8e-80	96.8
WP_001153740.1\|1857315_1857759_+	competence protein ComK	NA	NA	NA	NA
WP_001030469.1\|1857745_1858189_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-57	98.6
WP_001168909.1\|1858486_1859122_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_001096494.1\|1859558_1860272_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091445.1\|1860529_1860832_+	hypothetical protein	NA	NA	NA	NA
WP_001200550.1\|1861087_1861453_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.2e-59	98.3
WP_000623473.1\|1861449_1861803_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	4.2e-20	77.8
WP_000453315.1\|1862052_1862886_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.2e-158	99.6
WP_000366163.1\|1863097_1864006_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.4e-138	100.0
WP_000933822.1\|1864130_1865324_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000109907.1\|1865695_1867288_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.8
WP_072357842.1\|1867582_1868329_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	1.3e-140	97.6
WP_000672018.1\|1868333_1868807_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	1.0e-82	97.5
WP_000718107.1\|1868872_1869130_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778513.1\|1869126_1870128_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	8.2e-186	97.3
WP_000348367.1\|1870132_1871611_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	6.9e-282	96.7
WP_072357839.1\|1871769_1872225_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	1.4e-79	98.6
WP_072357764.1\|1872527_1873178_+	calcium-binding protein	A0A2H4PQM8	Staphylococcus_phage	9.5e-34	67.6
WP_000070657.1\|1873259_1874255_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	2.9e-74	96.8
WP_047213559.1\|1874329_1874956_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	2.8e-75	92.4
WP_000627546.1\|1874996_1875338_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	3.0e-55	94.7
WP_000414223.1\|1875438_1876011_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	7.1e-25	93.1
WP_000864137.1\|1876208_1876766_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	2.0e-77	96.2
WP_000747794.1\|1877393_1877837_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000742593.1\|1878156_1878606_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_047213567.1\|1879241_1880432_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	1.5e-45	34.7
WP_000028660.1\|1880424_1881981_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	1.2e-287	99.2
WP_001038741.1\|1882344_1883064_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	4.0e-126	95.8
WP_001038864.1\|1883189_1883909_-\|protease	serine protease	A0A2H4PQP7	Staphylococcus_phage	2.4e-123	92.9
WP_001039451.1\|1883966_1884689_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	8.1e-127	95.8
WP_001092761.1\|1886475_1887054_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	1.5e-67	74.0
WP_025174462.1\|1887527_1887746_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	4.1e-26	83.3
WP_000550245.1\|1887999_1888473_+	hypothetical protein	NA	NA	NA	NA
WP_031927813.1\|1888477_1889269_+	DUF1828 domain-containing protein	NA	NA	NA	NA
WP_000782462.1\|1889637_1890621_-	beta-channel forming cytolysin	A0A2H4PQH7	Staphylococcus_phage	3.4e-184	98.8
WP_000473594.1\|1890622_1891558_-	beta-channel forming cytolysin	A0A2H4PQI5	Staphylococcus_phage	5.1e-174	99.7
WP_000617702.1\|1892521_1892758_+	hypothetical protein	NA	NA	NA	NA
WP_115288416.1\|1892778_1893555_+	DUF1828 domain-containing protein	NA	NA	NA	NA
WP_031927816.1\|1894718_1895888_+	hypothetical protein	NA	NA	NA	NA
WP_031927817.1\|1897172_1897949_-	staphylococcal enterotoxin type G	NA	NA	NA	NA
WP_001236367.1\|1898232_1898988_-	staphylococcal enterotoxin type N	A0A075M4C7	Staphylococcus_phage	3.9e-39	41.0
WP_031927818.1\|1899026_1899812_-	staphylococcal enterotoxin type C1/U	A0A097PAT7	Streptococcus_pyogenes_phage	3.8e-45	42.7
WP_031927819.1\|1899962_1900694_-	staphylococcal enterotoxin type I	A0A1X9H080	Staphylococcus_phage	5.1e-28	39.2
WP_000821651.1\|1900728_1901448_-	staphylococcal enterotoxin type M	A0A1X9H080	Staphylococcus_phage	5.8e-24	34.3
WP_129754921.1\|1901726_1902509_-	staphylococcal enterotoxin type O	A0A1X9H080	Staphylococcus_phage	6.7e-34	37.9
WP_000132893.1\|1903968_1904523_-	serine hydrolase family protein	NA	NA	NA	NA
WP_000167553.1\|1904842_1906243_-	protoporphyrinogen oxidase	NA	NA	NA	NA
WP_000162881.1\|1906266_1907190_-	ferrochelatase	NA	NA	NA	NA
WP_000233535.1\|1907247_1908285_-	uroporphyrinogen decarboxylase	NA	NA	NA	NA
WP_047213579.1\|1908546_1909077_+	signal transduction protein TRAP	NA	NA	NA	NA
WP_115288411.1\|1909166_1910486_+\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA

DBSCAN-SWA_10

1985922 : 2085428

119

Staphylococcus_phage(76.62%)

holin,tRNA,terminase,head,integrase,transposase,protease,tail,portal,capsid

attL 2020193:2020210|attR 2085531:2085548

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001807150.1\|1985922_1987242_-\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
WP_115288418.1\|1987439_1988867_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_000027928.1\|1988879_1990337_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_000170162.1\|1990338_1990641_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_000957020.1\|1991006_1992545_+	sodium/proline symporter PutP	NA	NA	NA	NA
WP_000238681.1\|1992703_1993057_-	transcriptional regulator	NA	NA	NA	NA
WP_031927678.1\|1993181_1994141_+	nitronate monooxygenase	NA	NA	NA	NA
WP_000831693.1\|1994423_1995623_-	CamS family sex pheromone protein	NA	NA	NA	NA
WP_000774565.1\|1995635_1997639_-	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	5.8e-114	36.1
WP_000992924.1\|1997642_1999835_-	DNA helicase PcrA	A7KV33	Bacillus_phage	1.0e-135	42.2
WP_000272064.1\|1999831_2000524_-	heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
WP_001165363.1\|2000695_2000998_-	hypothetical protein	NA	NA	NA	NA
WP_000572880.1\|2001106_2002402_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.6e-16	32.9
WP_000827765.1\|2003261_2004428_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434533.1\|2004458_2004785_+	staphostatin A	NA	NA	NA	NA
WP_000669861.1\|2005075_2005249_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011539.1\|2005229_2005832_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040872.1\|2006100_2006922_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	7.9e-70	53.1
WP_000284433.1\|2006914_2008384_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	3.5e-108	45.1
WP_000897635.1\|2008567_2009644_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177828.1\|2009663_2010458_+	prephenate dehydratase	NA	NA	NA	NA
WP_001802312.1\|2010529_2010637_+	hypothetical protein	NA	NA	NA	NA
WP_000323164.1\|2010647_2012210_-	SLC13 family permease	NA	NA	NA	NA
WP_000275712.1\|2012414_2013512_-	pectate lyase	U5PWM6	Bacillus_phage	1.5e-47	34.6
WP_000149686.1\|2013883_2014444_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|2014496_2015426_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001790680.1\|2015618_2015792_-	hypothetical protein	NA	NA	NA	NA
WP_042908133.1\|2015843_2017223_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_115288419.1\|2017342_2018371_-	lactonase family protein	NA	NA	NA	NA
WP_001284658.1\|2018830_2019211_-	penicillinase repressor BlaI	NA	NA	NA	NA
WP_001096367.1\|2019200_2020958_-	beta-lactam sensor/signal transducer BlaR1	NA	NA	NA	NA
2020193:2020210	attL	NA	NA	NA	NA
WP_000733622.1\|2021064_2021910_+	penicillin-hydrolyzing class A beta-lactamase BlaZ	A0A1B0VBP7	Salmonella_phage	4.4e-31	33.9
WP_000612779.1\|2022223_2022634_+	YolD-like family protein	U3PG23	Staphylococcus_phage	3.1e-30	53.5
WP_000410574.1\|2024051_2024417_-\|transposase	transposase	NA	NA	NA	NA
WP_000026850.1\|2024425_2026489_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_000706213.1\|2026491_2027604_-\|integrase	tyrosine-type recombinase/integrase	P97010	Streptococcus_pyogenes_phage	1.7e-11	31.6
WP_000267034.1\|2028149_2028323_-	hypothetical protein	NA	NA	NA	NA
WP_001188066.1\|2028773_2029814_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000713075.1\|2029870_2030713_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001033968.1\|2030709_2031267_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966288.1\|2031326_2031851_-	membrane protein	NA	NA	NA	NA
WP_000182842.1\|2031971_2032535_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221656.1\|2032600_2033341_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_115288420.1\|2033340_2034213_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_000645727.1\|2034209_2034890_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991298.1\|2034890_2035787_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	1.1e-16	30.2
WP_000691584.1\|2035783_2036164_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681972.1\|2036421_2036598_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|2036840_2036939_-	hypothetical protein	NA	NA	NA	NA
WP_001068524.1\|2037138_2038425_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000671713.1\|2038695_2038986_-	MAP domain-containing protein	NA	NA	NA	NA
WP_115288421.1\|2039000_2040437_-	MAP domain-containing protein	NA	NA	NA	NA
WP_000669791.1\|2041394_2041574_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	1.4e-24	98.3
WP_001791826.1\|2041884_2042145_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000702263.1\|2042196_2042547_-	complement inhibitor SCIN-A	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
WP_001110821.1\|2043056_2043353_-	peptidoglycan hydrolase	A0A1P8L6B4	Staphylococcus_phage	1.1e-48	94.9
WP_000920038.1\|2044042_2044534_-	staphylokinase	A0A1W6JQ12	Staphylococcus_phage	4.7e-86	99.4
WP_000861038.1\|2044724_2045480_-	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
WP_000611512.1\|2045491_2045746_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_031762631.1\|2045797_2045905_+	hypothetical protein	NA	NA	NA	NA
WP_072357969.1\|2045957_2046134_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	6.5e-22	96.6
WP_000340977.1\|2046276_2046651_-	hypothetical protein	G4KNR3	Staphylococcus_phage	3.3e-39	100.0
WP_001040255.1\|2046706_2046994_-	hypothetical protein	A0A075LZJ6	Staphylococcus_phage	5.8e-44	100.0
WP_000654329.1\|2047040_2047193_-	hypothetical protein	D2JLG0	Staphylococcus_phage	1.2e-19	98.0
WP_031927805.1\|2047182_2050968_-	phage minor structural protein	D2JLF9	Staphylococcus_phage	0.0e+00	99.4
WP_115288422.1\|2050983_2052474_-\|tail	phage tail protein	D2JLF8	Staphylococcus_phage	1.8e-298	99.8
WP_042908137.1\|2052473_2057123_-\|tail	phage tail tape measure protein	A0A1V0E5H1	Staphylococcus_phage	0.0e+00	98.2
WP_000570353.1\|2057178_2057301_-	hypothetical protein	D2JLF6	Staphylococcus_phage	6.9e-15	100.0
WP_000442602.1\|2057360_2057807_-	hypothetical protein	O80053	Staphylococcus_phage	1.9e-73	96.6
WP_000570652.1\|2057871_2058825_-\|tail	phage tail protein	A7TWD0	Staphylococcus_phage	6.2e-175	100.0
WP_000611452.1\|2058825_2059206_-	hypothetical protein	D2JLF3	Staphylococcus_phage	5.8e-68	100.0
WP_000501244.1\|2059202_2059580_-	HK97 gp10 family phage protein	D2JLF2	Staphylococcus_phage	1.1e-61	100.0
WP_000975314.1\|2059579_2059915_-\|head,tail	head-tail adaptor protein	A7TWC7	Staphylococcus_phage	1.1e-59	100.0
WP_001177483.1\|2059901_2060234_-\|head,tail	phage head-tail adapter protein	D2JLF0	Staphylococcus_phage	2.1e-58	100.0
WP_001252099.1\|2060242_2060401_-	hypothetical protein	D2JLE9	Staphylococcus_phage	3.2e-20	100.0
WP_000849950.1\|2060436_2061684_-\|capsid	phage major capsid protein	A7TWC4	Staphylococcus_phage	5.0e-209	100.0
WP_000032525.1\|2061771_2062356_-\|head,protease	HK97 family phage prohead protease	D2JLE7	Staphylococcus_phage	9.8e-107	100.0
WP_011447040.1\|2062348_2063539_-\|portal	phage portal protein	D2JLE6	Staphylococcus_phage	1.8e-224	100.0
WP_000644965.1\|2063604_2063844_-	membrane protein	A7TWC1	Staphylococcus_phage	7.0e-35	100.0
WP_000133304.1\|2063818_2065513_-\|terminase	phage terminase large subunit	D2JLE4	Staphylococcus_phage	0.0e+00	100.0
WP_000919026.1\|2065515_2065983_-\|terminase	phage terminase small subunit P27 family	D2JLE3	Staphylococcus_phage	1.1e-81	100.0
WP_000817289.1\|2066112_2066457_-	HNH endonuclease	D2JLE2	Staphylococcus_phage	4.2e-65	100.0
WP_115288423.1\|2066472_2066925_-	nucleoside triphosphate pyrophosphohydrolase family protein	D2JLE1	Staphylococcus_phage	5.1e-79	99.3
WP_000282747.1\|2067039_2067519_-	hypothetical protein	D2JLE0	Staphylococcus_phage	3.8e-72	100.0
WP_000265043.1\|2067541_2067742_-	DUF1514 family protein	A0A2I6PDV9	Staphylococcus_phage	1.4e-28	100.0
WP_000573772.1\|2067882_2068083_-	hypothetical protein	NA	NA	NA	NA
WP_000195827.1\|2068079_2068286_-	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.4e-20	76.5
WP_000185669.1\|2068322_2068859_-	hypothetical protein	R4IG63	Staphylococcus_phage	9.4e-96	100.0
WP_001057953.1\|2068851_2069100_-	DUF1024 family protein	A0A2K9VBU0	Staphylococcus_phage	1.3e-36	97.6
WP_000399886.1\|2069092_2069368_-	hypothetical protein	Q4ZCN9	Staphylococcus_virus	8.0e-43	96.7
WP_001808043.1\|2069367_2069778_-	hypothetical protein	Q4ZCP0	Staphylococcus_virus	8.0e-71	100.0
WP_001126836.1\|2069788_2070037_-	hypothetical protein	A0A2I6PDI0	Staphylococcus_phage	3.2e-43	100.0
WP_000536056.1\|2070037_2070400_-	hypothetical protein	B7T0B4	Staphylococcus_virus	2.0e-49	80.0
WP_001187268.1\|2070400_2070586_-	DUF3113 family protein	Q4ZA46	Staphylococcus_virus	4.6e-26	96.7
WP_069631884.1\|2070590_2070995_-	DUF1064 domain-containing protein	Q9G020	Staphylococcus_virus	2.6e-66	97.0
WP_001123673.1\|2071004_2071226_-	DUF3269 family protein	A7TWN4	Staphylococcus_phage	1.3e-35	100.0
WP_000628837.1\|2071238_2071397_-	hypothetical protein	A0A0H3U301	Staphylococcus_phage	3.4e-22	100.0
WP_000443353.1\|2071393_2072179_-	ATP-binding protein	A0A0H4J332	Staphylococcus_phage	1.9e-145	100.0
WP_015978328.1\|2072974_2073667_-	hypothetical protein	A0A0H4ISQ1	Staphylococcus_phage	8.0e-132	100.0
WP_015978330.1\|2073679_2074231_-	hypothetical protein	A0A0H4IPV5	Staphylococcus_phage	3.4e-101	100.0
WP_001288251.1\|2074260_2075034_-	AAA family ATPase	A0EWP9	Staphylococcus_virus	3.1e-140	99.6
WP_000002516.1\|2075033_2075513_-	siphovirus Gp157 family protein	A0A0H4J328	Staphylococcus_phage	1.1e-82	100.0
WP_000291067.1\|2075527_2075788_-	DUF1108 family protein	A1KX65	Staphylococcus_virus	8.9e-44	100.0
WP_000165365.1\|2075792_2076095_-	DUF2482 family protein	A0A0F6N3N3	Staphylococcus_phage	7.0e-48	99.0
WP_000066020.1\|2076187_2076349_-	DUF1270 domain-containing protein	A0A2I6PDF7	Staphylococcus_phage	1.9e-20	100.0
WP_001120935.1\|2076345_2076666_-	DUF771 domain-containing protein	Q4ZDR7	Staphylococcus_virus	1.5e-56	100.0
WP_000801108.1\|2076724_2076952_+	hypothetical protein	A7TWL9	Staphylococcus_phage	1.7e-38	100.0
WP_000389906.1\|2076953_2077145_-	hypothetical protein	A7TWL8	Staphylococcus_phage	2.8e-26	100.0
WP_064138580.1\|2077194_2077551_+	DUF2513 domain-containing protein	A0A1P8L6H1	Staphylococcus_phage	2.3e-58	99.2
WP_001148859.1\|2077545_2077740_-	hypothetical protein	A0A1P8L6G6	Staphylococcus_phage	4.3e-19	100.0
WP_001148551.1\|2077756_2078527_-	phage antirepressor KilAC domain-containing protein	Q4ZCB0	Staphylococcus_virus	3.5e-128	90.6
WP_115288424.1\|2078542_2078797_-	helix-turn-helix transcriptional regulator	C5I625	Staphylococcus_phage	6.9e-41	97.6
WP_000874712.1\|2078986_2079625_+	LexA family transcriptional regulator	A0A0E3TAG1	Staphylococcus_phage	5.7e-116	99.5
WP_000694770.1\|2079820_2080003_+	hypothetical protein	A0A2I6PDF8	Staphylococcus_phage	9.1e-27	98.3
WP_001013104.1\|2080038_2080185_+	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	1.1e-14	89.6
WP_000191459.1\|2080181_2080796_-	hypothetical protein	A7TW88	Staphylococcus_phage	7.9e-107	100.0
WP_000857174.1\|2080903_2081941_+\|integrase	site-specific integrase	A7TWL3	Staphylococcus_phage	1.7e-178	99.7
WP_047213639.1\|2083334_2084351_-	bi-component leukocidin LukGH subunit G	A0A1X9IGW5	Staphylococcus_phage	1.1e-25	30.2
WP_000791409.1\|2084372_2085428_-	bi-component leukocidin LukGH subunit H	A0A1X9IGW5	Staphylococcus_phage	1.9e-36	34.6
2085531:2085548	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP022683

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 14639

Staphylococcus_phage(42.86%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012816664.1\|2770_3868_+	zinc-binding alcohol dehydrogenase family protein	NA	NA	NA	NA
WP_010994055.1\|3882_4752_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	6.7e-27	34.5
WP_012816665.1\|4735_5461_+	hypothetical protein	NA	NA	NA	NA
WP_010994057.1\|5489_5663_+	hypothetical protein	NA	NA	NA	NA
WP_115288471.1\|5989_6664_-\|transposase	IS6-like element ISSau6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.4e-112	87.9
WP_010994058.1\|6893_7460_-	recombinase family protein	E5FFF9	Burkholderia_phage	4.2e-30	42.0
WP_162007740.1\|7811_8333_-	replication-associated protein RepA family protein	NA	NA	NA	NA
WP_012816646.1\|8329_8710_-	replication initiator protein A	Q9MCM7	Streptococcus_virus	7.7e-20	47.1
WP_010994021.1\|10457_11201_-	hypothetical protein	A0A143FPS7	Mycobacterium_phage	9.5e-06	27.3
WP_010994022.1\|11773_12604_-	hypothetical protein	NA	NA	NA	NA
WP_012816649.1\|12680_12995_-	hypothetical protein	NA	NA	NA	NA
WP_010994024.1\|13147_13564_+	hypothetical protein	A0A2H4JEH6	uncultured_Caudovirales_phage	3.8e-28	55.9
WP_010994026.1\|13805_14639_+	exfoliative toxin B	A0A0E3T8P7	Staphylococcus_phage	2.7e-49	40.6

DBSCAN-SWA_2

18474 : 19281

Clostridium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010994033.1\|18474_19281_-	ParA family protein	E2ELL2	Clostridium_phage	4.2e-15	27.1

DBSCAN-SWA_3

31286 : 31916

Staphylococcus_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012816661.1\|31286_31916_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	2.0e-105	88.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP022682

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP022683

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection