CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP028498	Streptomyces chartreusis strain WZS021 chromosome 7	1 crisprs	DinG,csa3,DEDDh	0	0
NZ_CP028508	Streptomyces chartreusis strain WZS021 chromosome 17	1 crisprs	csa3,Cas14u_CAS-V,c2c9_V-U4	0	1
NZ_CP028512	Streptomyces chartreusis strain WZS021 chromosome 21	0 crisprs	NA	0	0
NZ_CP028495	Streptomyces chartreusis strain WZS021 chromosome 4	0 crisprs	Cas14u_CAS-V	0	0
NZ_CP028499	Streptomyces chartreusis strain WZS021 chromosome 8	0 crisprs	csa3	0	0
NZ_CP028511	Streptomyces chartreusis strain WZS021 chromosome 20	0 crisprs	c2c9_V-U4	0	0
NZ_CP028513	Streptomyces chartreusis strain WZS021 chromosome 22	0 crisprs	NA	0	0
NZ_CP028504	Streptomyces chartreusis strain WZS021 chromosome 13	1 crisprs	Cas14u_CAS-V	0	1
NZ_CP028492	Streptomyces chartreusis strain WZS021 chromosome 1	4 crisprs	csa3,cas3	1	0
NZ_CP028502	Streptomyces chartreusis strain WZS021 chromosome 11	0 crisprs	NA	0	0
NZ_CP028494	Streptomyces chartreusis strain WZS021 chromosome 3	1 crisprs	Cas9_archaeal,DEDDh,cas3,csa3	0	1
NZ_CP028496	Streptomyces chartreusis strain WZS021 chromosome 5	0 crisprs	NA	0	0
NZ_CP028500	Streptomyces chartreusis strain WZS021 chromosome 9	0 crisprs	NA	0	0
NZ_CP028493	Streptomyces chartreusis strain WZS021 chromosome 2	0 crisprs	NA	0	0
NZ_CP028507	Streptomyces chartreusis strain WZS021 chromosome 16	0 crisprs	WYL,csa3	0	0
NZ_CP028506	Streptomyces chartreusis strain WZS021 chromosome 15	0 crisprs	NA	0	0
NZ_CP028509	Streptomyces chartreusis strain WZS021 chromosome 18	0 crisprs	casR,csa3,WYL	0	0
NZ_CP028505	Streptomyces chartreusis strain WZS021 chromosome 14	1 crisprs	WYL,cas4,DEDDh	0	0
NZ_CP028503	Streptomyces chartreusis strain WZS021 chromosome 12	0 crisprs	NA	0	0
NZ_CP028501	Streptomyces chartreusis strain WZS021 chromosome 10	0 crisprs	NA	0	0
NZ_CP028510	Streptomyces chartreusis strain WZS021 chromosome 19	0 crisprs	NA	0	0
NZ_CP028497	Streptomyces chartreusis strain WZS021 chromosome 6	2 crisprs	RT,WYL,csa3,DEDDh	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP028498_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028498_1

101404-101480

Orphan

Consensus_repeat	Method
CCGCCGCCAAGAAGACGACCGCCAAGAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028498_1

>merge|NZ_CP028498|1|101404-101480|CRISPRCasFinder
CCCCCGCGAAGAAGGCCGCCGCCAAGAAGACGACCGCCAAGAAGACTGCGGCGAAGAAGACGACGGCAGCCAAGAAG

>NZ_CP028498|1|1|101404-101480|CRISPRCasFinder
CCCCCGCGAAGAAGGCCGCCGCCAAGAAG	ACGACCGCCAAGAAGACTG
CGGCGAAGAAGACGACGGCAGCCAAGAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028498.1\|WP_107908332.1\|94413_96330_+\|glycogen-debranching-protein	unknown	unknown	gnl\|CDD\|225942
NZ_CP028498.1\|WP_107907474.1\|88761_89397_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028498.1\|WP_107907478.1\|99713_100601_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP028498.1\|WP_107907482.1\|111708_112653_-\|sucrase-ferredoxin	unknown	unknown	gnl\|CDD\|227101
NZ_CP028498.1\|WP_107907485.1\|114015_115323_+\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|223597
NZ_CP028498.1\|WP_107907480.1\|104362_106486_+\|type-IIA-DNA-topoisomerase-subunit-B	unknown	unknown	gnl\|CDD\|235501
NZ_CP028498.1\|WP_030945102.1\|103686_103917_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028498.1\|WP_107907472.1\|87029_87731_+\|ribonuclease-HII	unknown	unknown	gnl\|CDD\|234574
NZ_CP028498.1\|WP_107907473.1\|87799_88441_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP028498.1\|WP_107907486.1\|115319_117776_-\|DNA-topoisomerase-IV-subunit-A	unknown	unknown	gnl\|CDD\|235503
NZ_CP028498.1\|WP_107907484.1\|113287_113839_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028498.1\|WP_107907470.1\|84589_86137_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340879
NZ_CP028498.1\|WP_107907475.1\|89711_91877_-\|RecQ-family-ATP-dependent-DNA-helicase	unknown	unknown	gnl\|CDD\|223588
NZ_CP028498.1\|WP_107907483.1\|112897_113134_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028498.1\|WP_107907476.1\|92020_93805_+\|DUF4192-domain-containing-protein	unknown	unknown	gnl\|CDD\|379390
NZ_CP028498.1\|WP_107907481.1\|106734_107196_+\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NZ_CP028498.1\|WP_107907471.1\|86323_86947_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NZ_CP028498.1\|WP_107907477.1\|97564_99550_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP028498.1\|WP_107907479.1\|102714_103572_+\|serine-protease	unknown	unknown	gnl\|CDD\|238113
NZ_CP028498.1\|WP_030945089.1\|108966_109647_-\|HTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|226931

Protein	Function_ID	Function_description	E-value
NZ_CP028498.1\|WP_107908332.1\|94413_96330_+\|glycogen-debranching-protein	gnl\|CDD\|225942	COG3408, GDB1, Glycogen debranching enzyme [Carbohydrate transport and metabolism].	6.795e-24
NZ_CP028498.1\|WP_107907478.1\|99713_100601_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	4.48354e-45
NZ_CP028498.1\|WP_107907482.1\|111708_112653_-\|sucrase-ferredoxin	gnl\|CDD\|227101	COG4759, COG4759, Uncharacterized protein conserved in bacteria containing thioredoxin-like domain [Posttranslational modification, protein turnover, chaperones].	1.29446e-27
NZ_CP028498.1\|WP_107907472.1\|87029_87731_+\|ribonuclease-HII	gnl\|CDD\|234574	PRK00015, rnhB, ribonuclease HII; Validated.	6.85486e-86
NZ_CP028498.1\|WP_107907473.1\|87799_88441_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	7.1162e-06
NZ_CP028498.1\|WP_107907486.1\|115319_117776_-\|DNA-topoisomerase-IV-subunit-A	gnl\|CDD\|235503	PRK05561, PRK05561, DNA topoisomerase 4 subunit A.	0
NZ_CP028498.1\|WP_107907485.1\|114015_115323_+\|GTP-binding-protein	gnl\|CDD\|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	4.55159e-68
NZ_CP028498.1\|WP_107907470.1\|84589_86137_-\|MFS-transporter	gnl\|CDD\|340879	cd17321, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.68511e-68
NZ_CP028498.1\|WP_107907480.1\|104362_106486_+\|type-IIA-DNA-topoisomerase-subunit-B	gnl\|CDD\|235501	PRK05559, PRK05559, DNA topoisomerase IV subunit B; Reviewed.	0
NZ_CP028498.1\|WP_107907471.1\|86323_86947_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	6.498e-17
NZ_CP028498.1\|WP_107907476.1\|92020_93805_+\|DUF4192-domain-containing-protein	gnl\|CDD\|379390	pfam13830, DUF4192, Domain of unknown function (DUF4192).	1.06838e-74
NZ_CP028498.1\|WP_107907481.1\|106734_107196_+\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	6.15457e-27
NZ_CP028498.1\|WP_107907475.1\|89711_91877_-\|RecQ-family-ATP-dependent-DNA-helicase	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	8.28061e-127
NZ_CP028498.1\|WP_107907477.1\|97564_99550_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.03936e-40
NZ_CP028498.1\|WP_107907479.1\|102714_103572_+\|serine-protease	gnl\|CDD\|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	1.22259e-62
NZ_CP028498.1\|WP_030945089.1\|108966_109647_-\|HTH-domain-containing-protein	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	1.59607e-70

>NZ_CP028498.1|WP_107907478.1|99713_100601_+|FadR-family-transcriptional-regulator
MSTLAHTMMTAARAADSGLAGPGDLDRYPYAEASVADRVGVPAWDSAEPELGRVGRRAAGSRGRGLHGQLVQQLGQMIVSGDLGADRPLVPEEIGQRFEVSRTVVRESLRVLEAKGLVSARPNVGTRVRPVSDWNLLDPDIIEWRAFGPQRDDQRRELSELRWTIEPLAARLAAGHGRDDVQQRLADMVEIMSHAMGQGDVLTFSRADTEFHSLLIQVAGNRMLEHLSGIVSAALQVSGGPVTGCDRPNETSLTLHSRIVDALATGDGAAAENAMRQLLTVHPEVERVVPAPREH
>NZ_CP028498.1|WP_107907477.1|97564_99550_+|ABC-transporter-ATP-binding-protein
MIQAIGLTSNPRKEFPPALDDVSFEAQAGCVTALLGGAGAGKTTALRLMLELQQGRGVTFFRGRPLHRMAHPSREVGVLLGDVPGHPARSVRGHLRMLCAAAGVPARRADEVLEVVGLVSLRDERLGTLSRGMDRRLGLACTLLADPHTLVLDDPAEGLTTRERRWLHGALRAHAAQGGTVLLTTADAKEAARTADRVVTLERGRLVADQDAAEFARTRLRPRVAVRTPHASRLATLLGKQARTAHRSVEVVRESGNRLSVYGSSCADVGEIAFRNGILVHQLADEIGDMGPGPDTDPDGIEPRADEESRSAYRDAAPAKADAGVSSRRRRGAAPRRGERRTPAGDLASAPELSQAPDEGQDGVAAHETSQGTVGEPSGRDDGSRVSDHPAHDLPDLPPPISVRPAPSPLRPLRYELRRALGVGTGFVTAGVVLVVSALTAVVLARIGHTPHARLLAAWPRELPLPPAALGAGLLGAIAFGDEFRHPALAADRGTVPRRLGLLAAKLLVASATALVLAVLTVGCNIEVLYLVYGRELAEVPAGWLSLSASWIGLVVGCSWAGVLAAGLFRSTTAGLAAVVTVPIVVVPLVQQVLEGPSVRTAAGFPLRLREVLLSQWPFGGERYLAAVARVVGQPVGGAMTLSLAALLCAYLFTTLRSRVR
>NZ_CP028498.1|WP_107908332.1|94413_96330_+|glycogen-debranching-protein
MCVALPGLAISTDQGQLTGQGLDGFYRAGRRMLSRCQIRVAGREPLALQAWMTTADCVRFVGTLRTSPHAGPDPDVVVERTRHANGTERITLRSAAVRPLRLPVEVALATDLADLGSIACGNAGPELPATVHDSGLRWSSDRGSSTVTADPPPTDALASAGLLRWEFELPPGGVAYIELRVRSDGVGPMRAVGRAATSPLPPARAAGDDPRGEALLRTSIDDLQGLLVRDPTHPSDTHLAAGAPWRCGMASADALAAARMTLPLGTRLAAGTLRTLARTQLRDKGPQSGMIPGPRRDAGTHLPPGCTGTEATLLFPALLAEARRWGLPEPEVEELLPAAERCLSWLRTTVGDGAYLPDPHPGGPVRCETQAHAHRAALLGADLLDTCGRSGGDELRHWAGELRAAFRTDFWIDDLGGGRPAAARTPDGRPVPHLGAAAAHLLDTGLLGGGELAPGLLDKVQTEQLARLLGAPAMDSGWGLRGLSVKEAGYNPFGHRSGAVRVHETAIAVAGLAAADYEKEASALLRGVLAAAEAFGHRLPDMYAGEARTEGSAPLPHPAACRPAATSAAAGVLLLTTLAGIRPDAPAGTVTLRPMRGAPLGEIVLTGLRVAGAPFSVRVSRLGLAMVEEAADGLQLRA
>NZ_CP028498.1|WP_107907476.1|92020_93805_+|DUF4192-domain-containing-protein
MTNHSEATGSHENDGTTGQEQPLAPRATDQNEARDMRGGHGESPGTARRENPLDCTEYKGRLPEHQVTLRTPAELADALPYLLGYRPEDSMVLAALHDRDGRGRFGGRARLGIPASADDWDAAATQLAHGLVTGSERRGARPEQIVAFLCQEPAQGETGRQVMERLRPLSQKMRLACGGLDVPVVEALCISDGRYWSYCCDRTECCPAEGRPMGLPGTSVLAAAAAYAGVQVRGTLSELRARLLPWETTAALEQEIALDRGAMALVPRILDGEQRAGVAEETLELAVLLRNRFAAAPAVPGTLTADLRDDELLDHEEAARLILGLQDRATRDRVAEWMEGDEAPPALRLWRALARRCVGPYREHGAAPLTLAGWVAWSTGDEVEAREAFAMALGADADYLFARLLHQACNEGLDPESIRRCLRTERAGREGAAEAGQQDVLGDGEEPADGSKRGEAVKHASTSDVGDRRRSRHSMRSPGGLSRVARSVVRKRAASASRARTAAGSHPSAARPCGNASEVSKDAGSRTAKGASPRSGSDSATRAGKTTAPRTARHSAPSEVKGSAPRIPKQRAVRQSEVGPDGTSPKNTGVEGEA
>NZ_CP028498.1|WP_107907475.1|89711_91877_-|RecQ-family-ATP-dependent-DNA-helicase
MEHTSNADLRTAADAVLARLVGDDTGAARLREDQWRAIEALVADRRRALVVQRTGWGKSAVYFVATSLLRSQGSGPTVIVSPLLALMRNQVEAAARAGIHARTINSSNTEEWDTIQSEIAAGEVDVLLVSPERLNNPDFRDQVLPKLASATGLLVVDEAHCISDWGHDFRPDYRRLRTMLADLPPGVPVLATTATANARVTADVAEQLGTGGTSDALVLRGPLDRDSLSLSVLRLPDAAHRMAWLADHLDDLPGSGIIYTLTVAAAEEVTAFLRHRGHTVASYTGKTENADRQQAEDDLLANRVKALVATSALGMGFDKPDLGFVVHLGSPSSPIAYYQQVGRAGRGVEHAEVLLLPGQEDEAIWQYFASLAFPSEDLVHRTLDVLARSDRPLSLPALEPLVELRRSRLETMLKVLDVDGAVHRVKGGWIATGQPWVYEAERYDWVARQRKAEQQAMREYASTTGCRMEFLQRQLDDEGAKPCGRCDNCAGARFTADMSSVALDAARVDLGRAGVEVEPRRMWPTGLPAIGVDLKGRIPAGELAAPGRALGRLSDIGWGNRLRPMLAPHAPDGPVPDDVAKAVVGVLVDWAKGPDGWASGAQDAVPRPVGVVTIASRTRPQLINSLGARIAEVGRLPLLASLEYAGEGSSVSRSNSAQRLKALDGALNVPGDLASALSENPGPVLLVDDFTETGWTLAVAARMLRRAGAQGVMPLVLAVQG
>NZ_CP028498.1|WP_107907474.1|88761_89397_-|hypothetical-protein
MTFGFAPSSAASMSTSADLSAASANSLARMLEPAEWAAAGIPLLRNPREIVSGLHSRHRPRPATAIVAVLDAEERLRASASFTRRAAPADGWMFRNALLSQLRRVIPHDLRRRTPVRTAVLLYCREGDARWTEEDGAWMWGLRDACTLHGLRCGAYITLTNDGWQVLGEGRGGRRPNADSSPEPFATSESPVPLPRTGGAASEVLRRAAAR
>NZ_CP028498.1|WP_107907473.1|87799_88441_+|hypothetical-protein
MPLIPEEPQIHESAQGPRATPATGRTAPTPRPVPGPRPAAPSRPGRPGPVRPAPPVQRAPRDVAGAKPGPSGPAASVAPAPASATPQIQLIPASPEGALDAAEEAVDLLLDSGRAPGEVLVITTGEQHPWATHELSFGDTSYWAQHDAGDDVFYADASAASRATARPVIVVAVNGGSDTAAADVLPLALGKAGALLIVCGDAQRINSVLGAGV
>NZ_CP028498.1|WP_107907472.1|87029_87731_+|ribonuclease-HII
MPYEPPTHTVERSLRATTGAKIIAGVDEVGRGAWAGPVTVCAAVTGLRRPPEGLTDSKLLTVKRRNELAVVLRTWVTSYALGHASPEEIDKLGMTAALRLAACRALEALPVRPDAVILDGKHDYLGAPWKVRTVIKGDQSCVAVAAASVIAKVQRDKMMAELGIDHADFGFADNAGYPSPVHKAALAERGPTPYHRLSWAYLDALPQWQHLKKVRTWVDGSVPEIEGQLGFDF
>NZ_CP028498.1|WP_107907471.1|86323_86947_+|TetR-family-transcriptional-regulator
MVTSRWTAAPAQAASLRRRGAVLERAILEAALEQLSTVGWNGLTMEGVAAGAQTGKAAVYRRWPSKEDLVADALRAGLPNFESAPDLGSVREDLLALCRQAREAMYSRPGFALRSVIHECDTLQAERFHGVIFEGVVEPTIALLREVITRGIERGEVREDAANSYVFDAIPAMMMYRSKMCGSEWGDGDLEEMIDQLMVPLLRPTAD
>NZ_CP028498.1|WP_107907470.1|84589_86137_-|MFS-transporter
MTTSQLIKDQIPGAARRQGHPGIALTVIAACQLMVVLDATIVNIALPHIQDALKFSTTDLTWVVSSYTLTFGGLLLLGGRAGDILGRRRVFMTGILLFTLASLLGGLAQEPWQLLAARVLQGMGGAIASPTSLALITTTFPEGPERNRAFGVFAAVSAGGGAIGLLAGGMLTEWLDWRWVLFVNVPIGIVIAVLAPLYINESERHSGRFDIAGAVTSTAGMASLVYGFIRAADEGWRDSLTIGSFAAAVVLLLAFAFIESRAKEPITPLKMFADRNRSGTYVIMLSLAAAMFGMFFYVVLFVQNVLQYSPIEAGLAFLPVTVVIALGAGLSQRFLPVLGPKPFMLAGSALAAIGLAWQTLITADSSYAGGVLGPMLVFGFGMGLNFVTLTITAVSGVAQHEAGAASGLLNATQQVGGSLGLSILTTVFGTASKDEAEKQLPKFMAEGSAEQKAEFAKTHQLPGSWGHEVLTQGISTGFVAAASMAVIALATAWLVIRVRKSDLDALSGTAGPMAG
>NZ_CP028498.1|WP_107907479.1|102714_103572_+|serine-protease
MRRPFARALARPLVMAAVATAVPLATAAPAAADSVVVGGFPVDVSDSPWTVALSSRDRFGGTRAGQFCVGVAVGRTTVLTAAHCLSEGVLGSAPEQVRDFKVITGRSDLLSGSGHEIPVRGAWVNPDYDEDSNSGDFAVVSLSQALPASAVIGMAGPGDPAYVPGTPALVYGWGDVTGAGDYPRGLRAARVHVLPDALCSQAYPGGGDGRYMAGSMLCAGERTGGRDACQGDSGGPLVAQGKLIGLVSWGNGCGRAGSPGVYTRVSEIVRAMGSRAGAQESAAGG
>NZ_CP028498.1|WP_030945102.1|103686_103917_-|hypothetical-protein
MTTVLTPASPLTAADRCDRCGAQAYVRVVLLSGGELLFCAHHGRKFEPELKKIAAEIQDETERLTSVPASASEEER
>NZ_CP028498.1|WP_107907480.1|104362_106486_+|type-IIA-DNA-topoisomerase-subunit-B
MTAETSVPSTALLAGADRDGSNYTARHLLVLEGLEAVRKRPGMYIGSTDSRGLMHCLWEIIDNSVDEALGGYCDHIEVILHDDGSVEVRDNGRGIPVDVEPKTGMSGVEVVMTKLHAGGKFGGGSYAASGGLHGVGASVVNALSARLDVEVDRSGHTHAISFRRGVPGAFATDGPDAKFEAKSGLRKTKKIPKTRNGTRVRYWADRQIFLKDAKLSLENLHQRARQTAFLVPGLTIVVRDEFGLGDGGSKGEESFRFDGGISEFCEYLATDKPVCDVLRFTGQGTFKETVPVLDEHGQMTPTQVTRELVVDVAMRWGTGYDTTLKSFVNIIATPKGGTHVAGFETAVAATMNEVLRTKKMLRVAEDDIVKDDALEGLTAVVTVRLAEPQFEGQTKEVLGTSAARRIVNTVIAKELKAFLTSTKRDAAAQARVVLEKAVAAARTRIAARQHKDAQRRKTALESSSLPAKLADCRSDDVDRSELFIVEGDSALGTAKLARNSEFQALLPIRGKILNVQKSSVTDMLKNAECGAIIQVIGAGSGRTFDIDAARYGKIIMMTDADVDGSHIRTLLLTLFQRYMRPMIEAGRVFAAVPPLHRIELVQPKKGQDKYVYTYSDRELRDKLMEFQSKGVRYKDTIQRYKGLGEMDADQLAETTMDPRHRTLRRISLTDLEAAERVFDLLMGNDVAPRKEFISSSAATLDRSRIDA
>NZ_CP028498.1|WP_107907481.1|106734_107196_+|DUF485-domain-containing-protein
MHSSDGRPREATGARYDDPWYDALASGWGESDGPDTPEAAPPPAGDVYLEVQRSAAFREVRSRYRRFVVPAVVVFLSWYVAYVVAATTAPGLMARPVMGAVNVAMLAGLGQFLTTFLLTWAYARHARLRRDRAALELRWDTQELTRVAKGGAA
>NZ_CP028498.1|WP_030945089.1|108966_109647_-|HTH-domain-containing-protein
MIEVLVVDDDTRVARVNAAYVEKVPGFHVAGEAHNAAEALRRVEELPQLDLVLMDHYLPDETGLAVVQEMRRRGHQTDVIMVTAARDITTVQAAMRQGALQYLVKPFAFAGLRAKLEAYAELRRTLDGGGEAEQAEVDKIFGALSAPTEPDLPKGHSPTTAELVRQALMNSEGPLSAQEIAERTGVSRQTAQRYLKLLERTGRARLTLKYGDAGRPEHRYVWATRA
>NZ_CP028498.1|WP_107907482.1|111708_112653_-|sucrase-ferredoxin
MSTCSTVSQDLDEPIAGTAATATTWLLLEQPGPWGAKALTQSHLDPALGRALEAAAQGTGVRIALIRRPGRHADCGGPAERQVYVAHTVPGNVWLHAATITDPQHLLDLDFTALGMGDHHTFDSVLQGQPHTGDPLALVCTNGKRDRCCALLGRPLAAELAASGVDGVWEVTHLGGHRFSPTLLVLPYGYAYGRAQAHAVKEVLHSVQEGRIVVEGCRGNSAWERPGQAAELAVRRATGEAAAEALSVVRTDGAAPRWEVTVAHVDGRHWRVSVAQGTSAPPRPESCGTSVLGSPARMDVVALRELRPTTALAS
>NZ_CP028498.1|WP_107907483.1|112897_113134_-|hypothetical-protein
MKIVRRIGVPPSARGSTSGANCPDVFELSDGNFAVIGTEATEALDPELPADAARADYERIVIVSRETLIRAKADIPDA
>NZ_CP028498.1|WP_107907484.1|113287_113839_-|hypothetical-protein
MATRKIMAGRLATTAAGLLLATATLTLASRQRRLEEARLQMRQLELEELASRRKALEHQQRMHWQLLSKAIDDPSLAAVIDTYDKSIPAEKRRQFFYANAWYVNLYHLYRMGILDLDGLFGRLREIFQSPVLREYWEASRGQRATLDPSSDEAKIGRMVDALIKDLDEADTDEWWVVGNPPPT
>NZ_CP028498.1|WP_107907485.1|114015_115323_+|GTP-binding-protein
MPNVCPASAANNRSLRGDSSGSYPGSAFRSSYVRRAASRCTRRREKGRTLSQQSPGPQQIPVVVLAGFLGSGKTTLLNHLLHRSGGTRVGAIVNDFGAIEIDAMAVAGALGDSTVSLGNGCLCCAVDASELDVYLERLARPSTGIDVIVIEASGLAEPQELVRMLLASEHPGIVYGGLVEVVDAAEFDGTRAKHPEIDRHLALADLVVVNKLDRAPDGGRVLGLVRELADRAAVVPATHGRIDPEFLFDCRPSEERVGQLSFDDLHEHTGDGDGDDHDGHHAHLHTAYDSLSFVSEQPLDPRRLMGFLDSRSEGLYRIKGYVDFGPYDAANRYAVHAVGPFLRFYPEPWAGVDVDAGTRLTQLVLIGSGIDSDALAKDLEGCKSDAPHAADEHGMWGVLRYVQDPDGQDPDGQDPDAQDSGEQGTDEQGPDGPPA
>NZ_CP028498.1|WP_107907486.1|115319_117776_-|DNA-topoisomerase-IV-subunit-A
MARRSTKTPPPDDTYEEKILDIDVVDEMQGSFLEYAYSVIYSRALPDARDGLKPVHRRIVYQMNEMGLRPERGYVKCARVIGEVMGKLHPHGDASIYDALVRMAQPFSMRVPLVDGHGNFGSLGNDDPPAAMRYTECRQAQATSLMTESIDEDTVDFTPNYDGQEREPVALPAAFPNLLVNGASGIAVGMATNMPPHNLGEVIGAARHLIRHPNADLETLMKHVPGPDLPTGGRIVGLAGIRDAYETGRGTFKIRATVEIETVTARRKGLVVTELPFTVGPEKVIAKIKDLVGSKKIQGIADVKDLTDREHGLRLVIEIKNGFVPEAVLEQLYKLTPMEESFGINNVALVDGQPLTLGLKELLEVYLDHRFEVVRRRSEFRRSKRRDRLHLVEGLLTALVDIDEVIRLIRSSENSAQAKERLMERFSLSEIQTQYILDTPLRRLTKYDRIELESEKERLNAEIAELTRILDSDAELRKLVSAELAAVAKKFGTERRTVLLESAGTPVSAVPLQVADDPCRVLLSSTGLLARTANGDPFAEDDDARRSKHDVIVSAVPATARGEVGAVTSAGRLLRINVIDLPQLPETASRPNLAGGVPLAEFVSLDDGETLVCLITLDESSPGLALGTAQGVVKRVVPDYPSNKEELEVITLKEGDRIVGAIELRTGEEDLVFITDDAQLLRYQAAQVRPQGRAAGGMAGIKLTEGAKVISFTAVDPAVDAVVFTVAGSRGTLDDSVQTTAKLTPFDQFPRKGRATGGVRCQRFLKGEDCLSLAWAGATPARAAQKNGTPAELPEMDPRRDGSGVSLAKTVSVVAGPV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP028504_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028504_1

208246-208345

Orphan

Consensus_repeat	Method
TGTGACCTAGCTGCCGCGCGGAGTGCTGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028504_1

>merge|NZ_CP028504|1|208246-208345|CRISPRCasFinder
TGTGACCTAGCTGCCGCGCGGAGTGCTGGCGGCTGGTGCACGACTACAGTGAGCTCATCACGGGCCGAGTTGTGACCTAGCTGGCGCGCGGAGTGCTGGC

>NZ_CP028504|1|1|208246-208345|CRISPRCasFinder
TGTGACCTAGCTGCCGCGCGGAGTGCTGGC	GGCTGGTGCACGACTACAGTGAGCTCATCACGGGCCGAGT
TGTGACCTAGCTGGCGCGCGGAGTGCTGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028504.1\|WP_107909039.1\|217884_218196_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379062
NZ_CP028504.1\|WP_107909043.1\|222524_225101_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP028504.1\|WP_107909030.1\|196042_198895_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP028504.1\|WP_107909038.1\|215614_217876_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP028504.1\|WP_107909031.1\|199168_200881_-\|polyketide-synthase	unknown	unknown	gnl\|CDD\|238429
NZ_CP028504.1\|WP_107909037.1\|211347_214236_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197715
NZ_CP028504.1\|WP_107909026.1\|188246_189386_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NZ_CP028504.1\|WP_107909032.1\|201694_202129_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226415
NZ_CP028504.1\|WP_107909028.1\|190209_190719_-\|nucleoside-2-deoxyribosyltransferase	unknown	unknown	gnl\|CDD\|377443
NZ_CP028504.1\|WP_107909034.1\|206337_207987_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP028504.1\|WP_107909029.1\|190715_191726_-\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|238211
NZ_CP028504.1\|WP_107909040.1\|218249_218543_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028504.1\|WP_107909033.1\|202225_204172_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197715
NZ_CP028504.1\|WP_107909044.1\|226253_226484_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028504.1\|WP_107909042.1\|221475_222462_-\|sphingomyelin-phosphodiesterase	unknown	unknown	gnl\|CDD\|132436
NZ_CP028504.1\|WP_107909027.1\|189378_190197_-\|hydroxymethylpyrimidine/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|238574
NZ_CP028504.1\|WP_107909036.1\|209370_210768_-\|cytosine-permease	unknown	unknown	gnl\|CDD\|224374
NZ_CP028504.1\|WP_107909041.1\|219487_220054_+\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238496
NZ_CP028504.1\|WP_107908981.1\|204239_205424_+\|IS701-family-transposase	unknown	unknown	gnl\|CDD\|379252
NZ_CP028504.1\|WP_107909035.1\|208652_209042_-\|ASCH-domain-containing-protein	unknown	unknown	gnl\|CDD\|119345

Protein	Function_ID	Function_description	E-value
NZ_CP028504.1\|WP_107909039.1\|217884_218196_-\|ATP-binding-protein	gnl\|CDD\|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	1.08911e-06
NZ_CP028504.1\|WP_107909043.1\|222524_225101_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	1.11328e-13
NZ_CP028504.1\|WP_107909030.1\|196042_198895_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.03507e-14
NZ_CP028504.1\|WP_107909038.1\|215614_217876_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	1.71528e-15
NZ_CP028504.1\|WP_107909031.1\|199168_200881_-\|polyketide-synthase	gnl\|CDD\|238429	cd00833, PKS, polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.	1.08621e-174
NZ_CP028504.1\|WP_107909037.1\|211347_214236_+\|hypothetical-protein	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	3.18209e-16
NZ_CP028504.1\|WP_107909026.1\|188246_189386_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	1.05506e-43
NZ_CP028504.1\|WP_107909032.1\|201694_202129_+\|hypothetical-protein	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	1.63637e-10
NZ_CP028504.1\|WP_107909028.1\|190209_190719_-\|nucleoside-2-deoxyribosyltransferase	gnl\|CDD\|377443	pfam05014, Nuc_deoxyrib_tr, Nucleoside 2-deoxyribosyltransferase. Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyzes the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides.	3.8598e-06
NZ_CP028504.1\|WP_107909034.1\|206337_207987_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.98687e-80
NZ_CP028504.1\|WP_107909029.1\|190715_191726_-\|thymidylate-synthase	gnl\|CDD\|238211	cd00351, TS_Pyrimidine_HMase, Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the biosynthesis of DNA precursors and are active as homodimers. However, they exhibit distinct pyrimidine base specificities and differ in the details of their catalyzed reactions. TS is biologically ubiquitous and catalyzes the conversion of dUMP and methylene-tetrahydrofolate (CH2THF) to dTMP and dihydrofolate (DHF). It also acts as a regulator of its own expression by binding and inactivating its own RNA. Due to its key role in the de novo pathway for thymidylate synthesis and, hence, DNA synthesis, it is one of the most conserved enzymes across species and phyla. TS is a well-recognized target for anticancer chemotherapy, as well as a valuable new target against infectious diseases. Interestingly, in several protozoa, a single polypeptide chain codes for both, dihydrofolate reductase (DHFR) and thymidylate synthase (TS), forming a bifunctional enzyme (DHFR-TS), possibly through gene fusion at a single evolutionary point. DHFR-TS is also active as a dimer. Virus encoded dCMP-HMase catalyzes the reversible conversion of dCMP and CH2THF to hydroxymethyl-dCMP and THF. This family also includes dUMP hydroxymethylase, which is encoded by several bacteriophages that infect Bacillus subtilis, for their own protection against the host restriction system, and contain hydroxymethyl-dUMP instead of dTMP in their DNA.	1.60997e-44
NZ_CP028504.1\|WP_107909033.1\|202225_204172_+\|hypothetical-protein	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	3.60911e-15
NZ_CP028504.1\|WP_107909042.1\|221475_222462_-\|sphingomyelin-phosphodiesterase	gnl\|CDD\|132436	TIGR03395, Sphingomyelinase_C, sphingomyelin phosphodiesterase. Members of this family are bacterial proteins that act as sphingomyelin phosphodiesterase (EC 3.1.4.12), also called sphingomyelinase. Some members of this family have been shown to act as hemolysins. [Cellular processes, Pathogenesis].	5.24027e-93
NZ_CP028504.1\|WP_107909027.1\|189378_190197_-\|hydroxymethylpyrimidine/phosphomethylpyrimidine-kinase	gnl\|CDD\|238574	cd01169, HMPP_kinase, 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of the hydroxyl group of HMP to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate (HMP-P) and then the phophorylation of HMP-P to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine pyrophosphate (HMP-PP), which is the substrate for the thiamine synthase coupling reaction.	1.03795e-64
NZ_CP028504.1\|WP_107909036.1\|209370_210768_-\|cytosine-permease	gnl\|CDD\|224374	COG1457, CodB, Purine-cytosine permease and related proteins [Nucleotide transport and metabolism].	3.70247e-81
NZ_CP028504.1\|WP_107909041.1\|219487_220054_+\|cysteine-hydrolase	gnl\|CDD\|238496	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.	1.47974e-32
NZ_CP028504.1\|WP_107908981.1\|204239_205424_+\|IS701-family-transposase	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.07944e-53
NZ_CP028504.1\|WP_107909035.1\|208652_209042_-\|ASCH-domain-containing-protein	gnl\|CDD\|119345	cd06553, ASCH_Ef3133_like, ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation.	3.98759e-32

>NZ_CP028504.1|WP_107909034.1|206337_207987_-|serine/threonine-protein-kinase
MGDWKVPGYVETRELGHGASGRVVMAIAPETGAHVAIKYLSPSLATDPSFIDVFRSEASLLGELDSPYVVRLHRYIESSDGAAIVMELVEGPTLRAVLQADGALEPEAALTVLKGSLIGLSSAHAVQIVHRDYKPENVLLTIDGISKLADFGIATHGSAAHPAAGTPYYMAPEQWRGEQPTYAGDVYAATVTFFECVAGKRPFYGDSLPELALQHTTAYPPLDQIPAHLQPLIMTGMAKDPLTRPATAEAFLTELENVACEAYGENWEERGRQALAAAALVLLCLHALHETDPSITTSLAETTLPSQDSSRRPSKVRRALAATGVAVGGLTVLAVSISGTGDITSNPTTNRSADPASVASPASSARGTASLTPSIPASASPVTPTSSFGPHLDPSSRPTSPAVGAPVPGRPASSRSSDADPVVPPASTEPTPEAAPLSVDNASAQLSTDSTGDRATALVRVTANSRAEIVLRLTWYRSDTTGTPGQQDGDVQTVRLQGKRAYELTIDHEFDSSSCPLYWGLQLQITPAAPDGPIYSQSPAPACTIPGRG
>NZ_CP028504.1|WP_107908981.1|204239_205424_+|IS701-family-transposase
MGGDLAGVRLWAGELDALHERFVHRFNREEPRQSALAYMRGLVAPLQRKNGWTLAEEAGHAGPDRIHRLLNRIEWEADEVLNDVRDYVVEHLGDREAVLVVDDTGFLKKGIRSAGVQRQYSGTAGRTENCQIGVFLAYATDRGRTLIDRRLYLPTSWTDDRDRCRRAGIDDTVGFETKVAMAKAMVRRAIADRVPFGWVTADAAYGYSKGWRFELEQANVFHVMATTRHDTVVTRWSIDHPVHDLFPGLPRQKWKRRSCGEGAHGRRIYDWARVEVRPWHREDRGHWVLARRSVSRPEEISYYIAYCPAGTTLDQLIRIAGSRWAVEECFQTAKQECGLDDYQVRRYPGWHRHMTLAMAAHACLTVLRARELDADKAETDPPSSSTSASPRSDD
>NZ_CP028504.1|WP_107909033.1|202225_204172_+|hypothetical-protein
MQTVASLTSLTQEQAREGLATLQSASLAEVPEPGVSQQGVYRLAHPLVRAAVYDQMSAGQRISAHRKAAQLLIARRDPAQDVAAHLLRLPPRGDAETVAVLRQAAADAFSKGMGEAALPYLRRALAEPPSEETLLPLLLEAGSAALQTNLVEATQNLKAAFDHSKDVQTRASLASGLGLALMWIGNVNEAIIVLNAALRELPPTDNDLRRALEATLLDVPFVAVGQQHLFSSLPRLRALPAAQTSGSGLLDCMIGAAAAHVGDPSGLPYLRRGLSNPRLLESISRGALLAVSGPFALAAYNPGEAIRVFASVMNEARSTGSIAMLCVCYMYRGMAWLRKGELTEAESDLKESLRLQSIAHVSVGNPSLAGFLVESLVEQGRLSDAEEILRDLKSLGDYASSGTLYYMLQGEARLLSAQGKHEESLKAALSAGARYTEHAGSNPAFVAWRSQAALSLHALGRTDEANAYARAECELARAWGAAFSLGRALRIAGRVAPGKDGLILLEESVDVLRSAEVPLEYAYALVEFGAEMRRARSRSKSRECLNEGLAVALQCGAKPLAELAQTELEAAGSHMRKPEKTPGMTILTLTPSEKRVAMLAAKGLANREIAQQLFITTKTVEFHLSNAYRKLQVNTRRDLKTRLVECEG
>NZ_CP028504.1|WP_107909032.1|201694_202129_+|hypothetical-protein
MLNGLAWLTSNLCQDSPLVLIVDDLHWIDEASLRFLSFLLPHQQDLPLMLLTATRPSEATASKLVNALITDPSCQLLQPAPLTSRASAALVGSIFGEEPALSFAQACHDATGGNPLLLVELARAVKRQGAVPGHPAAMRLLRSG
>NZ_CP028504.1|WP_107909031.1|199168_200881_-|polyketide-synthase
MTATKPAGAVAIVGIAGRFPGADDVDSLWAMLLEGREAVQQFTRTELETAGVPSDHMNDPNYRPVAACLADITHFDAACFGISPAEARLMDPQHRIFLECVWAALEDAGAAPYTCQRKIGVFGSSALSSYLLHHILPSDEYRGQAHSHHVLMGNDRDFLATSVSYRLGLRGPSMTVQSGCSSSLVAVDMAKTALLAGQCEVAVAGGVRISTPQTAGYHYQSDGTLSFDGHCRPFDAGASGMVRGSGCGVVVLKRLERALADRDNIYAVIAGSAVNNDGALKASYTTPSVAGQVEVIQQALAASSLPAADIGYVEAHGTGVYLGDPIEVTALAQAYTGAPNPMRVCALGSIKANIGHLGSAAGITGLIKAALVLHHQTIPPQINFSKPNPELALTETPFSIHTRSHQPLRPLRGAAVTSLGIGGTNAHCILAPAPTVPGHYRPPADGEYVLLLSAADEKRLADTAGDLAVYLDHSPTIRLDDLSYTLAFGREPLPHRAAVTAVTLREAVIGLKGLAAGAKSRMDDPRVHAWLHHAPAEAVSVGEVGTARKIRIPGVRLHRTHYWIDAPAPS
>NZ_CP028504.1|WP_107909030.1|196042_198895_-|LuxR-family-transcriptional-regulator
MDGSTFDLLEREAETASIVEAIQSVLTDHHGALLFIDAPAGIGKTSLLGRVKSVAGEQGMLVASARATSLEQNFAFGVVRQLFEPLLVELGPRNEEELWAGPAAAAREVFAPTGSLAGLGDFAVMQGLFWLAANIGQQRFLAMTIDDIQWCDVPSLRFFTHLLPRLDGIGMLLAVTQRSGEPTADDDLVDRLATDSTARLLRPQPLSKQATGEFLRRRFNDDLVDNFMSACYAATAGNPLLMSEVTRTIKAQGQNPEDASGHMHASVMGPQSVARLVSVRLARYPEASALAKAVAILGSDADLALAAELAYQEVSTAAENLSVLEQLEVLETQQNSQILSFIHPLVQAAFYESVGLAERANMHHRASELLMSRRADVEKVAAHKLRTAPAGDKVALAILESAAEQAMRRGAAQSALTYLDRALQEVQAESQRSRELKRQAGMVGLLVDLPKAADYLLQVLSTSRDPIERAALSEALGDALYLLGRAHQAVPLLEDAINGLGDGHEAVRQRLQSCLIHVTMSDAQLHDVSDRVAQQVRNSPSRPELGGRCLDAIVSLHSALTSTSMRPVVTRALRAVEGDLLITGANGTPAFFDAGYSLVVADRPEAMPFLDQAWADAQQRGGTHLVFVDLLLRSLAWYRRGHLAEAESDAAAAWELRGVIRPAGPFLAHFYADILLDLGRSEQAGEVLDWASTSGLPPTAGHWAWQSAGRGRYLLEQGRHAEALQQLSDAEGLLQPISWCNPAFLSWRSDMALCLSALGQYDDARRYAQEELALARDWGAPWALGRSLRVAGTVADRLTAMPYLEEAVSVLLPSPARLELAKAQLALGAAWRRAGHRQAARPYLRQAADTAELCGAAPLATEARLELSASGEKTERRPPAGLHALTPSERRVAELAAQKLTNRQIAQILHVTPKTVEIHLTSTYRKLEIADRRHLAAAMGTPAPPTVSKG
>NZ_CP028504.1|WP_107909029.1|190715_191726_-|thymidylate-synthase
MKHTGLTEAYLCNLDNLLSEAEYRNAPRGFASQENLGVSFSIEDPRRRLVPTKVRRSNIVFNFAEVLWYFAGREDLEYMSYYAPGISRFVNGAGVLTGTAYGPKIFDFGDTRLDQWASTALTLRQDSDTKRAVIQIYQPEELTVPGNPDVSCTLGLQFLARDGHLHLVSYMRANDAYRGMLSDIFSFTFLQELMARELGLELGRYTHMVGSLHLYEPDVRSAQRLLAACDGTEAEEDRMPPMPTGDQRPYVERVMWFEQRLRTDSVRLGISGIAALDLPEYWRQVVTLFELYRRYRYGTHAPEDALVDELNPLYRTMLINRFPNLLPTSHAKAAVA
>NZ_CP028504.1|WP_107909028.1|190209_190719_-|nucleoside-2-deoxyribosyltransferase
MTQHHRPIVFIGGPFKGAVDPETGVLAGDLRDRYDRLITFYENEGWDVLNAHREEGWGLSMVSAEACTERDFQWMRECDLFVAFPGDPASPGTHVEIGWASAMGRPTILLLEEAGSHAALVTGLAGIAPSTAYLTYSERPDFLMSLARATADLGDRVRASWPAVLASAG
>NZ_CP028504.1|WP_107909027.1|189378_190197_-|hydroxymethylpyrimidine/phosphomethylpyrimidine-kinase
MATAPLVCLTVGSSDSSGGAGIQGDIKTCMALGAYCATAIVGITAQNPGGVRSRADVPLDMISDQISTVMDELRIDVIKIGTVWSAEVMHLLADHFESLDVPVVFDPVMKTSAGSPMHTGDKALRAARQRLMAISTVVTPNVTEAQILADAPDIHMPFTLAQLVFSRGAKAVLITDAMGARGGDWLYDGEHHQPIAARQRYTTRCEHGAGCAHSTILAVLLARRHDLLSAAQEAHRLAAAAVRHGTVSVGSQDHPVDVAAGLTQLVAGSQHG
>NZ_CP028504.1|WP_107909026.1|188246_189386_-|FAD-binding-oxidoreductase
MAEVTVVGAGVVGLSVAWMLAEAGAAVTVVDSGPPGRGASGYAHGEIIPPSSDLQSLWRQSLAVYQRLAQHGDFGWDGQPIGTVILAHHHETGLLIARNRAYNAHGVETQLVDAGQLRGMEPSIAPAGGGALVLAEGRRVNPRQTVAALAGSARSVGVELNCDITVVGLRRAAGRWQLLFADGRRTQARKVVLATGLHTSQLAQGVGCRIPLVGVRGRILVTEPLPQTLSRIVSSVAAGPAALAATRTTLGDLAAGAPAIVAALMHQRRDGRFAIGASWSPALGPEDKYSPSRIAQAAVRRLPALADAAAEDSWSGVRPYAVDGRPVIDEIEEDLYACCGHGGEGFILGPGSAQLMAQIVLDRDGTHAAAASFSADRFT
>NZ_CP028504.1|WP_107909035.1|208652_209042_-|ASCH-domain-containing-protein
MWPRINDLRAMELGTPDDFRTELNSLVLCGKKTATTGLLTEYIKEGEILEHAGERLALLDVRGTQVATIEITDVQLLNFIDVSWEHVIAEGEGDVSLDGWRVAHTRYWRRLGTIVEDSTQVVCLMFRLI
>NZ_CP028504.1|WP_107909036.1|209370_210768_-|cytosine-permease
MAPSTRSDSGLIETHSIDHIPERDRHGKVWHQGPFWFTGNFVLTTMVIGFLGPTLGLNLTWSILSPLLGAAFGTFFMAFHANQGPRLGLPQMIQSRAQFGIKGAILPFTAVIFVYVGFNVFNVILATQGLQTLLPGGKVFWYLTTVILATVIAIIGHDLIHLVQRYLTYFLIASFAAITIYAFTRNGHAHPAGGFSWTAFLTAFSAAAGYQISYAVYVSDYSRYLPSHVSSKKVIWWTYIGACGSAAWLMTLGAVVGHLTPAPDVVDSLRTLGNDLFPGFGTGIVILSSIALISIMSVNAYGAMLTGASAVQAFRKVSPTRGTRVVGVLLTELTVLLIALALPDDYLGSFNTFVLLMLYFLIPWTAINLADFYWIRKGSYNIEAIYDPAGIYGNWSRNGLLSYVAGFLSMVPFFSTSLYTGPIAKSLDGADLSFAVGLVVSAGVYIILTRTRLPAQGKHPLEMVR
>NZ_CP028504.1|WP_107909037.1|211347_214236_+|hypothetical-protein
MLSVVRLLTEREDEGYLLVEAVAPMAVEAPGLIERDAELAAVGGALERAEAGEGSLIIVEGAPGLGKTSLLKSVEAAAERRGWLVMSARGGEMEQTLTFGVVRQLMRPMLVTSSAAQQEGYFTGPAQQAWSVLNAPGVDEAGDFAVLHGLYWLTVNLAQTRPVLMVVDDLHWLDPPSLRFLLYLQPRLGGLPVVVMTASRMVSGATGDLVEQLIADPECSLLRPRPLTEDGTARLLREQFQMEADPEFSIACHKAAGGNPLLLHELSSFAVKRNVQPHAQNASVVEELGPQSVAQHVAARASRLSSSALALMRAVAVLGDGTQVTSAAELANLGSTEALKAAEELSTTDILQQEGAGSFGVPVLSFVHPLVRAVLSQQMPTVERAEGHRRAADLLIAAGADAERVASHLLRTPSTGAPRHAEVLREAAAAAVSHGAPETAYAYLTRCLDEPLNSRERLDVLIRAGRTAHHVDASAGVHFLEEAAKSVPDGEQYAHIAQVLGDLYHLTGLFDAATDVRLQALRGLPDDQSDASRRLYAGLLATSIVTGLEPDIRARISELVRIASPSSVTGCELASVIACIKCIQGDPEAVSLALRGLTNDLLVQQTQVPMGLVCAWYTLAFADHPHALASVESAISHVHRHGGVGGLVGTLVYRALCRLRRGELREAIADGQQCMRATDASGISIARLHIGPWLAEAYLEQGALEEARTVLRWAGRNTSTAVPPQQYLQLATARLLREEGHYEEAFRSTEAAGASFEAVGGDNAAVLPWRSEAALSLHALGRQEEAVQYAEHDVVSARRWQSPVGIGRALRAAGVVAAGSDRLALLEEAVDLLSDTPARLYQAQALIDFGTELFIADKVDDARDRLRSGVDLAEMCGAPALVERGIAQLRATGARPRRTKLTGRAALTPSEVRVAQLAAEGHTNRAIAQELYVTPKTVEVHLSSVYRKLGIRDRKHLQEALD
>NZ_CP028504.1|WP_107909038.1|215614_217876_-|LuxR-family-transcriptional-regulator
MASAGFGSPSSSNEAAATLGRVAGQKPMVVCIDDIDRLDPVSLGVLVQVSKNKTTLLACTVTDNSSASEGVTALMRDGAVHRIQVSRLSEPHLAGICAAWFPQPIAHTSALALARLACGQVTTLRELLSGALEEGVLRNRHGIWYSDDRLPVRRLTELMRPRLAEIGPPHRAALELVSLVGSLSYETALVLAECSTWEALEASGLVETSSSSDGLLVTPVDDMVTQGLVATLPTLRRHRLLRSLLDAQSADVGTKSISTLQSALWRRELGLPVSDQHLVAAAHQAWWSYQWSVAEDLLRQAWGCSKDASVAELLDQILWAQEKVDDEIEKATSRPHPSQRSSWFARETYDSSAAVKAAQLLEEGACAAAWRLVEPVVSFDEDARRVVDAGSVALTALLRMGRPRTCVELGPRLLRMLDELRASRTAMPDASAITVLLAYARGACGERSGAILELRALMDVASGTHNAVLAARAGTMLALLLFEDGNVREAHRILAGGSARVAGPFRDMAQWGLAVTAAHLGDVEALRKASVDAASRQTDRQLALALREHHEGDTEAAVTRLVTSTKAAIASGAFGDAAKAVHLLGRLDRARVGSELCGTWTTSLEGPSDLLGVSFTQGTAKGAIERVQAAAEGFESAGTALYAAEAWAVCSRLHRKAGQARHATAATRRCSAARANYDGRPPVLLHVVENSETLTRREREIALMAAGGHTDQAIAELLVLSVRTVSNHLYSIYRKLGVSNRRALKGHFDQQGS
>NZ_CP028504.1|WP_107909039.1|217884_218196_-|ATP-binding-protein
MTVLTSQPAALPVVVPETFGQSAPASPDIRLRPHARLVGREENVAHIKAVLNEHRWRGLLLTGPAGTGKSRLLQEVEQMAREAGSRTLWVQSQGPCLSAPSLL
>NZ_CP028504.1|WP_107909040.1|218249_218543_-|hypothetical-protein
MFEIVESARRFPVSGLFLEAALTGRTVDLAVREQSDTGWAHPARLDRHGLSLPHERPGTVETQPVPGGTNYAIVARLQLQHFAGDAVIPVQKAHATP
>NZ_CP028504.1|WP_107909041.1|219487_220054_+|cysteine-hydrolase
MKSGPWRPALLVIDPQKSFEALPAWETRNNPQFEENVLTLIDHFKSQSFPIYYFMDGDFDARSVFHPTSPHYEFMDFVPVGDEDVVIHKLSRNCFTSTDLDLRLRTESVDEIVVTGIKTEQCCETTARVGSDLGYSVSFVTEATMTFDVPDYRNPERIFKAADIVEKTELLLANRFAKIVTVSELLVE
>NZ_CP028504.1|WP_107909042.1|221475_222462_-|sphingomyelin-phosphodiesterase
MKRKKRFSTALCALSLTPFALLHSHASAAAAPSPPQPFSIMTYNVMLLPSGLTDWEPDKRARAIGTSPHLAAEDVLVLSEMFDNSASDELLHRTTNTYPQRTPVIGRSSAGWDKTTGGYYGTPLEDGGVAILSKWPILRKEQHIFGGGCGADYWAAKGFAYAVVNISGQRVHVIGTHLQANDSGCSAGEAAQERSRQLGEITQFLESKRIPREELIAVAGDFNIRKGEAEHSRLLETLKVSSPQATAGAVASHDPATNSVAHYRDPGSRPSRLDYVFLKTGGSPAAPPNWVNKVDVTHTAPFRMHGRNFSDLSDHYPVRGFFDPPKNP
>NZ_CP028504.1|WP_107909043.1|222524_225101_-|helix-turn-helix-transcriptional-regulator
MLSHLARRHIDGVVIYGSEGVGKTRLVKEFAHQATRQGYRCDRIYANSLTKTIPLGALAHLLPANFNPANPLAVFHLAAANIREQRRRRLVLVVDDMHNLDSASTILLTQLVDAGLIFLAGTIRPSQTKIEVRRMLDSRESISRIYLSNLDHETTADVLSQALAGVVDGRTVFELHKASDGNILFLHELTDQAVNEGKLIRQKDGVWHLRAPLTVPQRLNALVARRIDETGPDQKDILHLLALSGPTSIKDLESVSGSGILMQMEDDGLIETHASGRRITADLAHPIYREVIAGQLSELQAREILRNRLSALESYGNRRSEDSLMIVSLRLAIGQPADPKLILRAAEFARFGHDYERVISLLALLSPEEISLGSQLLLGEALYELGEFQEADAVFIAALGRCESEEERVSVTIERTQNLAWGAAVPEQGIHTNSEILCNVTDPGLRRSLKVNEGAMRILAGRPKLGLQLIEDNLSADMNERIALYGAGLTVIGMSAVGTTEKAVSVGQKNSVRHTEASQRVVIQHSAAALSALSLAYMAYGDLEEARSTATEGYTRAVAEKAVQPSAWLAFDRARCEWLAGRLKTAYRWFARSLFMAKSNNLALVVGLAESGMRACGVLLDETVPSADDSGMTVQSEALFLAGETALGRAWALAAEGSMLPARNMLLNAASQARDAEFFTSEMLLLTEVVRLGGAEQIVDRLAQLGDICDGPFAQARKSLAIGMATTDPELLLSVSASLEKIGANLLAAEAAAAAARMLQRRNKTDISAYAVQTVARLTAYCECTTTPGLSLVDSPQPLTERELEIAYIASRGSSSKEIADTLALSVRTVDNHLHRVYGKLGITSRRQIAPALRAMEG
>NZ_CP028504.1|WP_107909044.1|226253_226484_+|hypothetical-protein
MREFCRRWIGRACVRIYRWMDSGAHEARQMLGLPAATVGAGWWSPSSSSMPKVEVDERHDHNLAGNRLVTLRLRRT

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

41143 : 205424

Mycobacterium_phage(14.29%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_107908953.1\|41143_42385_+\|transposase	transposase	A0A1D8ETH9	Propionibacterium_phage	3.2e-91	48.7
WP_107908954.1\|42996_45189_-	endonuclease I	A0A2P0VMP9	Tetraselmis_virus	2.5e-09	31.7
WP_107908955.1\|45312_46014_-	hypothetical protein	NA	NA	NA	NA
WP_107908956.1\|46027_46711_-	peptidase	D7RWE0	Brochothrix_phage	3.8e-17	38.3
WP_107909104.1\|47783_48479_-	SARP family transcriptional regulator	NA	NA	NA	NA
WP_107908957.1\|48680_49430_-	hypothetical protein	NA	NA	NA	NA
WP_107908958.1\|50035_51013_+	hypothetical protein	NA	NA	NA	NA
WP_107908959.1\|52159_52645_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_107908960.1\|53644_53920_+	hypothetical protein	NA	NA	NA	NA
WP_107908961.1\|54286_54862_+	hypothetical protein	NA	NA	NA	NA
WP_107908962.1\|55872_56685_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_107909105.1\|57338_58334_+	glycosyltransferase	A8CG95	Salmonella_phage	1.9e-57	37.0
WP_107908963.1\|58330_58765_+	GtrA family protein	NA	NA	NA	NA
WP_107908964.1\|58766_60302_+	hypothetical protein	NA	NA	NA	NA
WP_107908965.1\|60551_60911_+	hypothetical protein	NA	NA	NA	NA
WP_107908966.1\|61203_61842_+	hypothetical protein	NA	NA	NA	NA
WP_107908967.1\|62135_64073_+	hypothetical protein	NA	NA	NA	NA
WP_107909106.1\|64153_64348_+	hypothetical protein	NA	NA	NA	NA
WP_107908968.1\|64573_65923_+	glycosyl hydrolase	V9XSJ5	Choristoneura_murinana_nucleopolyhedrovirus	5.2e-34	28.8
WP_107908969.1\|66086_66332_+	hypothetical protein	NA	NA	NA	NA
WP_107908970.1\|67073_68009_-	KR domain-containing protein	NA	NA	NA	NA
WP_107908971.1\|68576_69416_-	DUF899 domain-containing protein	NA	NA	NA	NA
WP_107908972.1\|70120_70468_-	glyoxalase	NA	NA	NA	NA
WP_107908973.1\|70793_71840_-	bacillolysin	NA	NA	NA	NA
WP_107908974.1\|72109_72568_+	polyketide cyclase	NA	NA	NA	NA
WP_107908975.1\|72564_72915_+	ArsR family transcriptional regulator	NA	NA	NA	NA
WP_107908976.1\|72917_73373_+	SRPBCC domain-containing protein	NA	NA	NA	NA
WP_107908977.1\|76009_76348_+	hypothetical protein	NA	NA	NA	NA
WP_107908978.1\|77007_77238_-	hypothetical protein	NA	NA	NA	NA
WP_107908979.1\|77461_77707_+	hypothetical protein	NA	NA	NA	NA
WP_107908980.1\|77951_78530_-	N-acetyltransferase	NA	NA	NA	NA
WP_107908981.1\|84420_85605_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_107908982.1\|85863_86271_-	hypothetical protein	NA	NA	NA	NA
WP_107909107.1\|86525_87050_-	SigE family RNA polymerase sigma factor	NA	NA	NA	NA
WP_107908983.1\|87228_87792_-	hypothetical protein	NA	NA	NA	NA
WP_107908984.1\|88782_90963_+	hypothetical protein	NA	NA	NA	NA
WP_107908985.1\|90977_92906_+	VCBS repeat-containing protein	NA	NA	NA	NA
WP_107908986.1\|93711_94482_+	hypothetical protein	NA	NA	NA	NA
WP_107908987.1\|94621_95674_+	hypothetical protein	NA	NA	NA	NA
WP_107908988.1\|95912_96203_-	hypothetical protein	NA	NA	NA	NA
WP_107908989.1\|97995_98916_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_107909108.1\|100025_101311_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.1e-46	45.7
WP_107908990.1\|101370_102654_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_107908981.1\|102763_103948_+\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_107908991.1\|105223_106040_-\|transposase	IS5 family transposase	A0A0M5M147	Mycobacterium_phage	8.6e-24	34.4
WP_107908992.1\|107216_108056_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_107909109.1\|112366_112627_-	WhiB family transcriptional regulator	A0A023ZXD5	Mycobacterium_phage	1.6e-05	50.0
WP_107908993.1\|114758_116387_-	protein translocase subunit SecD	NA	NA	NA	NA
WP_107908994.1\|117886_118657_-	AAA family ATPase	U5N3V8	Enterobacteria_phage	2.6e-54	46.0
WP_107908995.1\|120328_121567_+\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_107908996.1\|122701_122911_+	hypothetical protein	NA	NA	NA	NA
WP_107908997.1\|122859_123288_+	hypothetical protein	NA	NA	NA	NA
WP_107908998.1\|123226_124144_-	NADP-dependent oxidoreductase	A0A2K9L339	Tupanvirus	5.3e-06	26.2
WP_107909110.1\|127355_127856_+	ATP-binding protein	NA	NA	NA	NA
WP_107908999.1\|132555_132765_+	hypothetical protein	NA	NA	NA	NA
WP_107909000.1\|137162_137987_+	enoyl-CoA hydratase	NA	NA	NA	NA
WP_107909001.1\|139279_139825_+	cytochrome P450	V5L3A3	Hirudovirus	4.1e-14	28.9
WP_107909002.1\|141779_143279_+	MFS transporter	NA	NA	NA	NA
WP_107909003.1\|145639_146584_+	hypothetical protein	NA	NA	NA	NA
WP_107909004.1\|146580_146922_+	divalent-cation tolerance protein CutA	NA	NA	NA	NA
WP_107909005.1\|147015_147252_-	hypothetical protein	NA	NA	NA	NA
WP_107909006.1\|152853_153105_+	hypothetical protein	NA	NA	NA	NA
WP_107909007.1\|153685_154654_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_107909008.1\|155165_156263_+	hydroxyneurosporene dehydrogenase	NA	NA	NA	NA
WP_107909009.1\|156522_156987_+	PaaI family thioesterase	NA	NA	NA	NA
WP_107909010.1\|159507_160278_-\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_107909011.1\|160366_161134_+\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_107909012.1\|161170_162115_-	sulfurtransferase	NA	NA	NA	NA
WP_107909111.1\|163253_164006_-\|transposase	transposase	NA	NA	NA	NA
WP_107909013.1\|164666_165878_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	2.3e-126	58.1
WP_107909112.1\|166494_167331_+\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_107908981.1\|167455_168640_+\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_107909014.1\|170378_171620_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_107909015.1\|171927_172380_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_107909016.1\|174150_175608_-\|transposase	transposase	NA	NA	NA	NA
WP_107909017.1\|176521_176890_+	hypothetical protein	NA	NA	NA	NA
WP_107909018.1\|177152_178736_+	MFS transporter	NA	NA	NA	NA
WP_107909019.1\|180798_180954_-	hypothetical protein	NA	NA	NA	NA
WP_107909020.1\|181657_182425_+\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_107909021.1\|183457_183883_-	hypothetical protein	NA	NA	NA	NA
WP_107909022.1\|184211_184733_-	hypothetical protein	NA	NA	NA	NA
WP_107909023.1\|184802_185726_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_107909024.1\|185733_186921_-	cytochrome P450	NA	NA	NA	NA
WP_107909025.1\|187462_188221_-	hypothetical protein	NA	NA	NA	NA
WP_107909026.1\|188246_189386_-	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_107909027.1\|189378_190197_-	hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	NA	NA	NA	NA
WP_107909028.1\|190209_190719_-	nucleoside 2-deoxyribosyltransferase	NA	NA	NA	NA
WP_107909029.1\|190715_191726_-	thymidylate synthase	G3MA60	Bacillus_virus	2.1e-27	27.7
WP_107909030.1\|196042_198895_-	LuxR family transcriptional regulator	NA	NA	NA	NA
WP_107909031.1\|199168_200881_-	polyketide synthase	D0R7J2	Paenibacillus_phage	1.2e-40	35.5
WP_107909032.1\|201694_202129_+	hypothetical protein	NA	NA	NA	NA
WP_107909033.1\|202225_204172_+	hypothetical protein	NA	NA	NA	NA
WP_107908981.1\|204239_205424_+\|transposase	IS701 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP028505

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP028505_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028505_1

67775-67878

Orphan

Consensus_repeat	Method
AGGGGCGCGGGGAACTGCGCGAAC	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP028505_1

>merge|NZ_CP028505|1|67775-67878|CRISPRCasFinder
AGGGGCGCGGGGAACTGCGCGAACGGTGGTGATGCCTGCGGTCACGTCTGGGCGCCGGTCGGCTGCAACGCCCTTCTTTTAGGGGCGCGGGGAACTGCGCGATC

>NZ_CP028505|1|1|67775-67878|CRISPRCasFinder
AGGGGCGCGGGGAACTGCGCGAAC	GGTGGTGATGCCTGCGGTCACGTCTGGGCGCCGGTCGGCTGCAACGCCCTTCTTTT
AGGGGCGCGGGGAACTGCGCGATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028505.1\|WP_107909161.1\|60469_61660_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173840
NZ_CP028505.1\|WP_107909173.1\|78733_79351_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP028505.1\|WP_107909167.1\|73553_73928_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380433
NZ_CP028505.1\|WP_107909171.1\|76890_77790_-\|DUF4436-domain-containing-protein	unknown	unknown	gnl\|CDD\|379624
NZ_CP028505.1\|WP_107909166.1\|72568_73537_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176459
NZ_CP028505.1\|WP_030954768.1\|61694_62132_-\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|377370
NZ_CP028505.1\|WP_107909164.1\|65226_66126_+\|slipin-family-protein	unknown	unknown	gnl\|CDD\|259808
NZ_CP028505.1\|WP_107909169.1\|74678_75551_+\|lipase	unknown	unknown	gnl\|CDD\|224001
NZ_CP028505.1\|WP_107909159.1\|56970_57186_+\|proteinase-inhibitor-I78	unknown	unknown	gnl\|CDD\|288556
NZ_CP028505.1\|WP_107909162.1\|62523_63750_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368211
NZ_CP028505.1\|WP_107909157.1\|53442_53889_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028505.1\|WP_107909172.1\|77975_78425_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|173926
NZ_CP028505.1\|WP_093745465.1\|78452_78593_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028505.1\|WP_107909160.1\|57276_58305_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NZ_CP028505.1\|WP_107909170.1\|75630_76662_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|376983
NZ_CP028505.1\|WP_107909168.1\|74058_74505_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP028505.1\|WP_107909174.1\|79373_79877_-\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|377233
NZ_CP028505.1\|WP_107909158.1\|53896_54937_+\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP028505.1\|WP_107909165.1\|66403_67486_+\|S1-family-peptidase	unknown	unknown	gnl\|CDD\|365866
NZ_CP028505.1\|WP_107909163.1\|64156_65062_+\|S1-family-peptidase	unknown	unknown	gnl\|CDD\|365866

Protein	Function_ID	Function_description	E-value
NZ_CP028505.1\|WP_107909161.1\|60469_61660_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173840	cd01151, GCD, Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.	0
NZ_CP028505.1\|WP_107909173.1\|78733_79351_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	4.47343e-26
NZ_CP028505.1\|WP_107909167.1\|73553_73928_-\|cupin-domain-containing-protein	gnl\|CDD\|380433	cd20299, cupin_YP766765-like, Rhizobium leguminosarum YP_766765.1 and related proteins, cupin domain. This family includes mostly bacterial proteins homologous to Rhizobium leguminosarum YP_766765.1, a protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.29542e-24
NZ_CP028505.1\|WP_107909171.1\|76890_77790_-\|DUF4436-domain-containing-protein	gnl\|CDD\|379624	pfam14494, DUF4436, Domain of unknown function (DUF4436). This is a family of membrane and transmembrane proteins from mycobacterial and related species. The function is not known.	1.20614e-56
NZ_CP028505.1\|WP_107909166.1\|72568_73537_+\|hypothetical-protein	gnl\|CDD\|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	6.4785e-49
NZ_CP028505.1\|WP_030954768.1\|61694_62132_-\|cell-division-protein-SepF	gnl\|CDD\|377370	pfam04472, SepF, Cell division protein SepF. SepF accumulates at the cell division site in an FtsZ-dependent manner and is required for proper septum formation. Mutants are viable but the formation of the septum is much slower and occurs with a very abnormal morphology. This family also includes archaeal related proteins of unknown function.	7.45649e-27
NZ_CP028505.1\|WP_107909164.1\|65226_66126_+\|slipin-family-protein	gnl\|CDD\|259808	cd08826, SPFH_eoslipins_u1, Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes a subgroup of the stomatin-like protein family (SLPs or slipins) that is found in bacteria and archaebacteria. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Bacterial and archaebacterial SLPs remain uncharacterized. This subgroup contains PH1511 from the hyperthermophilic archaeon Pyrococcus horikoshi.	3.96906e-90
NZ_CP028505.1\|WP_107909169.1\|74678_75551_+\|lipase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	1.20699e-26
NZ_CP028505.1\|WP_107909159.1\|56970_57186_+\|proteinase-inhibitor-I78	gnl\|CDD\|288556	pfam11720, Inhibitor_I78, Peptidase inhibitor I78 family. This family includes Aspergillus elastase inhibitor and belongs to MEROPS peptidase inhibitor family I78.	0.00210495
NZ_CP028505.1\|WP_107909162.1\|62523_63750_+\|hypothetical-protein	gnl\|CDD\|368211	pfam04959, ARS2, Arsenite-resistance protein 2. Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.	2.042e-07
NZ_CP028505.1\|WP_107909172.1\|77975_78425_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	1.67845e-09
NZ_CP028505.1\|WP_107909160.1\|57276_58305_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	6.00752e-31
NZ_CP028505.1\|WP_107909170.1\|75630_76662_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|376983	pfam03067, LPMO_10, Lytic polysaccharide mono-oxygenase, cellulose-degrading. This domain is found associated with a wide variety of cellulose binding domains. This is a family of two very closely related proteins that together act as both a C1- and a C4-oxidising lytic polysaccharide mono-oxygenase, degrading cellulose. This domain is also found in baculoviral spheroidins and spindolins, protein of unknown function.	1.86948e-64
NZ_CP028505.1\|WP_107909168.1\|74058_74505_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	3.33639e-14
NZ_CP028505.1\|WP_107909174.1\|79373_79877_-\|DUF402-domain-containing-protein	gnl\|CDD\|377233	pfam04167, DUF402, Protein of unknown function (DUF402). Family member FomD is a predicted protein from a fosfomycin biosynthesis gene cluster in Streptomyces wedmorensis. Its function is unknown.	4.49209e-17
NZ_CP028505.1\|WP_107909158.1\|53896_54937_+\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.15754e-54
NZ_CP028505.1\|WP_107909165.1\|66403_67486_+\|S1-family-peptidase	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	2.21295e-12
NZ_CP028505.1\|WP_107909163.1\|64156_65062_+\|S1-family-peptidase	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	5.33826e-12

>NZ_CP028505.1|WP_107909165.1|66403_67486_+|S1-family-peptidase
MKHRRIPKRRAAVAGAGIAALVAAGVTLQTANASETPETSAPKTLSVSAAGKLASTLVKDLGGDAAGSYYDTQAKSLVVNVLDEAAADAVEAAGAKARVVENSLAELKSARTTLKQDATIPGTAWVTDPATNRVVVTADRTVSDAEWAKLGKVVDGLGAKAELKRSKGEYKPFIAGGDAITGGSGRCSLGFNVVKGGEPFFLTAGHCTESIKDWSDSSGTQIGSNESSSFPDNDYGLVKYTAEVEHPSEVNLYNGSTQAISGAAEATVGMEVTRSGSTTQVHDGKVTGLDATVNYGNGDIVNGLIQTDVCAEPGDSGGSLFSGDKAIGLTSGGSGDCTAGGETFFQPVTEALSATGTEIG
>NZ_CP028505.1|WP_107909164.1|65226_66126_+|slipin-family-protein
MVEELVAAGVTLASAGLVYVAAAARVVKQYERGVVFRLGKLRPEVRGPGFTMIVPGVDKLRKVNMQIVTMPIPAQEGITRDNVTVRVDAVVYFKVTAPAEAVVRVEDYRFAVSQMAQTSLRSIIGKSELDDLLSSRERLNQGLELMIDSPAVEWGVTIDRVEIKDVSLPETMKRSMARQAEADRERRARVINADAELQASKKLAEAAHQMSDAPAALQLRLLQTVMAVAAEKNSTLVLPIPVELLRFLEKGAQVAVPGQGSGGDAQRAAPVESRTVQDELPSGEARLDPEPDVSILRQE
>NZ_CP028505.1|WP_107909163.1|64156_65062_+|S1-family-peptidase
MRIKRTTPRSGITRRTRLIAVSTGLVAAAAIAIPNATAAETPATFSAAQLKSASGSVLKADVPGTAWSVDSKTNRVTVTVDSTVSKAEIAKIKEQAGANADALTIKSVPGKFSKFIQGGDAIYASSWRCSLGFNVQDSSGNQYFLTAGHCTDGAGTWWSNSGHTSVIGSTAGSSFPGNDYGIVRYSGSVSRPGTANGVDITRAATPSVGTTVIRDGSTTGTHSGRVTALNATVNYGGGDVVGGLIQTTVCAEPGDSGGSLYGSNGTAYGLTSGGSGNCSSGGTTFFQPVTEALSAYGVSVY
>NZ_CP028505.1|WP_107909162.1|62523_63750_+|hypothetical-protein
MCGLCLSLRGDHGQFARIVTNYDGLLISVLTEAQAENAGGLRRTAGPCPLRGMRTASVAQGEGARLAAAVSLVLASAKVRDHVTDGDGLLARKPVALAARRVAAGWGAAGARGGSAVGFDTAVLVDAVDRQVGIETLAGLGTSVLTVTEPTETATAAAFAHTAILAGRPGNAEPLAEAGRMFGRLAHLLDAVEDRAADAEAGAWNPLTATGTSLAEARRLADDAVHGVRLALREVEFTDPGLAHLLLVHELRRSVDRAFGTVPTCGSHASHASHQPGQPGRPGPYGQPPQQPGPYGAPQNPYAGGGNPYAGGNPYAGGGGAPGGGAGGSGGGGGDFGGFGGFGGGPAPQPPKRRGFWAGCGMFWLLCCTCELCCAKEYEGPWSRKKREGCCRDCDCDGCDCCCPCDGC
>NZ_CP028505.1|WP_030954768.1|61694_62132_-|cell-division-protein-SepF
MGSVRKASAWLGLVDDNDDERYYDDDYSEGTEPGEAWVTDPRVKVATDVAEEKGRRIGTVTPDSFRDARAIGELFRDGVPVIMNLTAMEPADAKRVVDFAAGLIFGLRGSIDRVSNRVFLLTPADTEIISGERAAHREDGFYNQS
>NZ_CP028505.1|WP_107909161.1|60469_61660_+|acyl-CoA-dehydrogenase
MSASSKLPPFDPADPLGVDDLLEPEDLAVRGTVRAWAADRVLPYVAEWYEKGELPGIRELARELGEIGALGMSLEGYGCAGASAVQYGLACLELEAADSGIRSLVSVQGSLAMYAIHRFGSEEQKQAWLPRMASGEVIGCFGLTEPDHGSDPGSMRTYAKRDGSDWVLNGRKMWITNGSVSGVAVVWAQTDEGIRGFVVPADSAGFSAPEIKHKLSLRASVTSELVMDDVRLPADAVLPEVVGLKGPLSCLSHARYGIVWGAMGAARSCFEAAVDYAKTREQFGRPIGGFQLTQAKLADMALELHKGILLAHHLGRRMDAGRLRPEQVSFGKLNNVREAIDICRTSRTILGANGISLEYPVMRHATNLESVLTYEGTVEMHQLVLGKALTGLDAFR
>NZ_CP028505.1|WP_107909160.1|57276_58305_-|phosphatase-PAP2-family-protein
MRTERKLTRLDRVFARLDREPERPAHIDVPRMTRHRIVLFSATLAFYGAIVWAVVITSWLVRLDWQVMFFRPYQQWAEIHAFVDYYVVLGQRGPTAVMVAAWLGWRSWRQHTLRPLLALGVSLLLLNITVGAAKIGMGRLGPHYATTIGSNEMGLGGDIFPSGHTANAVVTWGILAYLASTPRARRWLSALSAVTSLGVGLSTVYLGTHWLSDVLLGWAAGLLILLALPWFEPLIARSEAWLFALRDRLRARRAGALPATAPVPVEAPVLLKPRPTASGDEAAACEASPPARSPRAPVYLAPGPHTARGERTPVTPAGSRRPPHTDRIGRGGTPTARPLTGG
>NZ_CP028505.1|WP_107909159.1|56970_57186_+|proteinase-inhibitor-I78
MAPIPKPPADPQDNPDAYVGLDADGAERLARERGWSTVRSLPPGAIITMEYRVGRLNFEVKDGQVARAWKG
>NZ_CP028505.1|WP_107909158.1|53896_54937_+|YafY-family-transcriptional-regulator
MLDTSARLLRLLSLLQAHRDWSGAELAGRLGVTPRTVRRDVDRLRELGYPVNASPGTGGGYQLGAGAELPPLLLDDDEAVAVAVGLRTAAGQGIEGIGETSVRALAKLEQVLPNRLRRRVSALNAFTVPMLRGPQPSAVDPAVLTELANLCRDSERLRFEYRDHEGASTRRSVEPHRLVCSERRWYLVAWDLDREDWRTFRVDRVIPKPPHGPRFAPRTPPAEDLAAYVSRGVSTRAYAAQAVVRLLVPLAEAAERVSPTAGQLEAEGPDSCLLRTGAGSLDVMVIHVMLMGFEFEVLEPVELVETIRTAQSRLARSLARAAEPPARAADGADRTPGTPSGPSAAS
>NZ_CP028505.1|WP_107909157.1|53442_53889_+|hypothetical-protein
MTPVSHAVPLRADCIADSAGGLTFDVSATGAPDTAHLVLRHREGPEEVTLPLAPATKGRLRAALPSSVSLLEGHWDAYASVTEEESDHRVASGAMDVHPHASRVPYETRQGNLSVECRLPVAPSGARGTAGSATMDPHSPARSALPSC
>NZ_CP028505.1|WP_107909166.1|72568_73537_+|hypothetical-protein
MTILCVRFQLPPTHEAALPGLLGLLEDFTPVVQALPPDAALADLRGAERYFGRDAVELASVIRVRALAHHGVDCAIGAGPGPMLARVALGEARPGVTCAVPEDAATEFLADKPVAALPGVGAATARTLCEYGLDTLGLVAAAPLSTLQRLIGAKAGRELREKASGIDRGRVVPDGVSRSLATERPFTRDELDPDRHRRALLSAAEELGARLRALDKVCRTLTLTVRYADRSSTTRSRTLKEPTAHSAALTRAAYGMYEALGLQRARVRALALRAEGLDPAEQASYQLTFDPLDEKARRIEEVADRARAKFGPHAVMPGSLAA
>NZ_CP028505.1|WP_107909167.1|73553_73928_-|cupin-domain-containing-protein
MPVIRASEAVTHEIHGARFVSYATPGTGSKELCAWRGEIPAGTKAPAHTVNREEILHLLDGELLVTLDDRTDRITAGDTLIINPGATLTVENPTGRTAVTWVTTSIGLTAELADGTLITPPWAN
>NZ_CP028505.1|WP_107909168.1|74058_74505_+|MarR-family-transcriptional-regulator
MQNSEAMALSAALLAVAGELTQRINDGVVARGFEGVRPAHGFAFARLAPAGATATDLAVHLGVTKQAASQLVDEIVRKGYAERRPHPDDARARLVVLTERGWACTRAAEEAAADAVRGWADVLGDVQVRALLGQLARIAPNGPVRPAW
>NZ_CP028505.1|WP_107909169.1|74678_75551_+|lipase
MLPWKRVLRPLAALLLTAAVAVVPAATTAQAAETAAAPSSGWNDYSCKPSAAHPRPVVLVHGTFANSVDNWLGLAPYLKDRGYCVFSLDYGQLPGVPFFHALGPIDKSAEQLSAYVDKVLAATGAAEADLVGHSQGGMMPRYYLKFLGGAGKVNALVGIAPNNHGTTLSGIANLLPYFPGAEDLLSAATPALAQQVVGSDFMTKLNAGGDTVPGVRYTVIATKYDEVVTPWRTQFLTGPDVKNVLIQDLCAVDISEHALIGITDRIAFHEVANALDPAHARPTTCASVFS
>NZ_CP028505.1|WP_107909170.1|75630_76662_-|LPXTG-cell-wall-anchor-domain-containing-protein
MSARRKAAAVATLGLTPLALTALAAAPASAHGSMGDPVSRVSQCYAEGPESPKSDACKAAVAAGGTQALYDWNGIRIGDAAGRHQELIPDGKLCSANSEEFKGLDLARADWPATSVSSGSYTFKYRVTAPHKGTFKVYITKAGYNPAKPLAWGDLDLSNPVATVTDPAASGGFYTFSGTLPQRSGKQLLYAVWQRSDSPEAFYSCSDVTFGGASGGGTSNGGGSTGSGSGDSNTDASAAPSASAPSEEQIEAGADQSTIEHHGHGDQDASTSAEPAAAAEDDASTAPANRPKAAGATENLAETGGDSSTAYLAMGGAATLALGSAVLFASVRRRAAAGGRHGR
>NZ_CP028505.1|WP_107909171.1|76890_77790_-|DUF4436-domain-containing-protein
MRPGRPAAPADSPRPRRSRRSVLRVLVLIAILIVVAVAVGSWLQFSERQTADTVHTVGSSAADRVDVEAAVQSVDAAGRELVLRVWVTPRGSLGEKGGAAPVTDLSLQTSGATLGDLEFAAHERLATKDVQVALLGGSISDYPFDAYKTDIAFRAQMGGEQVPVRMLFSNNDTLFSASAEPVPTRQEAVVALELTRSGSLLAFAVFMMVAMWALATSVLIGAWYLTTGSEGLVWPGLAWMAATLFALAAFRNTAPGTPPIGCVLDWFAFLWAESIIALCLVTVVITGVNKSLRKDAPAA
>NZ_CP028505.1|WP_107909172.1|77975_78425_+|GNAT-family-N-acetyltransferase
MTTEEIRPATAADVPAVKAVTDAAYTPYIERIGVTPVPMTADHAADVAAGKVFVTGDPVLGLVVIEAHEDHLFLDSIAVHPDAHGKGVGRRLLHFVDAHARALGLPEVRLYTNALMWENQKIYPKYGYELVERRAVGPYDRFHYRKRLT
>NZ_CP028505.1|WP_093745465.1|78452_78593_-|hypothetical-protein
MRRATVQKPLKRQSSTRRRVQEEAEESPSGRPEVRKDIARTWWPDS
>NZ_CP028505.1|WP_107909173.1|78733_79351_+|class-I-SAM-dependent-methyltransferase
MTNGEHAITGADLDWDSAAATFDDEPDHGLRDPEVRRAWASRLRSWLPDRASDVLDLGCGTGSLSLLAAEQGHRVTGVDRSPAMVDLARAKLAGRDAVFLAGDAAAPPVGEERFDVVLVRHVLWALPDPGRVLRHWRGLLRPGGRFVLVEGVWETDAGPAGIPADRLTGLLAPLAGQVRVESLSDDEALWGKPVADERYAVVATA
>NZ_CP028505.1|WP_107909174.1|79373_79877_-|DUF402-domain-containing-protein
MSANSAERPRSLEVVLVKGGRTKIRYAAELVADDGTRIAVRAPWSGDGVRDFGFVRFEPGDVFTEYYWRDRWYAVKEVRDAAGALKGWYCDVTRPAALSGTELVVEDLDLDLWRSADGTDVLRLDEDEFAESGLERSDPEAAAAAVAALDELEAFATVEGGLESLLA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_CP028492

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP028492_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028492_1

958981-959086

Orphan

Consensus_repeat	Method
CCCCAAGGGGCGCGGGGAACTGCGCGACCGGCCACGACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028492_1

>merge|NZ_CP028492|1|958981-959086|CRISPRCasFinder
CCCCAAGGGGCGCGGGGAACTGCGCGACCGGCCACGACGGACCCGCGGACACAAGACGACCACGGCACCCCAAGGGGCGCGGGGAACTGCGCGACCGGCCACGACG

>NZ_CP028492|1|1|958981-959086|CRISPRCasFinder
CCCCAAGGGGCGCGGGGAACTGCGCGACCGGCCACGACG	GACCCGCGGACACAAGACGACCACGGCA
CCCCAAGGGGCGCGGGGAACTGCGCGACCGGCCACGACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028492.1\|WP_107903750.1\|965291_965822_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_107903723.1\|948408_949092_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP028492.1\|WP_107903745.1\|963291_964422_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238868
NZ_CP028492.1\|WP_107903739.1\|960465_961326_-\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|223417
NZ_CP028492.1\|WP_107903728.1\|953278_954022_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_107903736.1\|959138_960269_-\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NZ_CP028492.1\|WP_107903719.1\|943989_944760_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|381284
NZ_CP028492.1\|WP_107903752.1\|966183_967956_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP028492.1\|WP_107903734.1\|958506_958962_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP028492.1\|WP_093747101.1\|968899_969856_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP028492.1\|WP_107903730.1\|955700_956849_-\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|128563
NZ_CP028492.1\|WP_107905241.1\|952921_953218_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_107903725.1\|952416_952770_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_107903743.1\|963085_963295_+\|acyl-CoA-carboxylase-subunit-epsilon	unknown	unknown	gnl\|CDD\|379386
NZ_CP028492.1\|WP_107905240.1\|950952_952194_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380079
NZ_CP028492.1\|WP_107903732.1\|956941_957760_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|181069
NZ_CP028492.1\|WP_107903748.1\|964702_965323_+\|septum-formation-inhibitor-Maf	unknown	unknown	gnl\|CDD\|178901
NZ_CP028492.1\|WP_107903741.1\|961436_963068_+\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NZ_CP028492.1\|WP_107905242.1\|968252_968801_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP028492.1\|WP_107903721.1\|944900_948140_-\|peptidase-S8	unknown	unknown	gnl\|CDD\|173812

Protein	Function_ID	Function_description	E-value
NZ_CP028492.1\|WP_107903723.1\|948408_949092_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.7778e-108
NZ_CP028492.1\|WP_107903745.1\|963291_964422_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.60584e-82
NZ_CP028492.1\|WP_107903739.1\|960465_961326_-\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|223417	COG0340, BirA, Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism].	1.15794e-60
NZ_CP028492.1\|WP_107903736.1\|959138_960269_-\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	5.45633e-29
NZ_CP028492.1\|WP_107903719.1\|943989_944760_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|381284	cd14775, TrHb2_O-like, Truncated hemoglobins, group 2 (O); uncharacterized subgroup. The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P).	1.27771e-58
NZ_CP028492.1\|WP_107903752.1\|966183_967956_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP028492.1\|WP_107903734.1\|958506_958962_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	1.12304e-06
NZ_CP028492.1\|WP_093747101.1\|968899_969856_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.9381e-81
NZ_CP028492.1\|WP_107903730.1\|955700_956849_-\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|128563	smart00267, GGDEF, diguanylate cyclase. Diguanylate cyclase, present in a variety of bacteria.	4.29988e-42
NZ_CP028492.1\|WP_107903743.1\|963085_963295_+\|acyl-CoA-carboxylase-subunit-epsilon	gnl\|CDD\|379386	pfam13822, ACC_epsilon, Acyl-CoA carboxylase epsilon subunit. This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes.	1.41783e-09
NZ_CP028492.1\|WP_107905240.1\|950952_952194_-\|hypothetical-protein	gnl\|CDD\|380079	pfam17964, Big_10, Bacterial Ig domain. This entry represents a bacterial Ig-like domain found associated with transpeptidase domains.	7.67597e-74
NZ_CP028492.1\|WP_107903732.1\|956941_957760_-\|enoyl-CoA-hydratase	gnl\|CDD\|181069	PRK07657, PRK07657, enoyl-CoA hydratase; Provisional.	4.02685e-73
NZ_CP028492.1\|WP_107903748.1\|964702_965323_+\|septum-formation-inhibitor-Maf	gnl\|CDD\|178901	PRK00148, PRK00148, Maf-like protein; Reviewed.	1.11333e-95
NZ_CP028492.1\|WP_107903741.1\|961436_963068_+\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NZ_CP028492.1\|WP_107905242.1\|968252_968801_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.50293e-11
NZ_CP028492.1\|WP_107903721.1\|944900_948140_-\|peptidase-S8	gnl\|CDD\|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	3.27787e-80

>NZ_CP028492.1|WP_107903734.1|958506_958962_+|hypothetical-protein
MSPDSGVGGLGAAESGPAPAPGTDAETDRSTNAAATLTPNAPKATPSATSAMGGLGTAPTTDSIVVPTPARTATTAPHGPGGAPAPTPPAARPGTQTPEPSTTTPRATAPAPETPGRPPTTPPPTQQPQPDDNSVCIPIIGLCVDPLPLDD
>NZ_CP028492.1|WP_107903732.1|956941_957760_-|enoyl-CoA-hydratase
MTEERFGEFVLVRRHGAGGAGGAGHVAELALDRPKAMNAVSTDMARSIAAACTALGADRDVRVVVLTSTHERAFCVGADLKERNSFSDADLVRQRPVARGAYTGVLELPVPTIAAVHGFALGGGFELALSCDVIVADGTAVVGLPEVSVGVIPGGGGTQLLPRRVGAARAAELIFTARRVEAAEARELGLVDVLVEDGRDREEALAMGSRMAANSPVGLRAAKRALRLGHGLDLRAGLEVEDAAWRATAFSGDRAEGVAAFNEKRKAEWPGE
>NZ_CP028492.1|WP_107903730.1|955700_956849_-|sensor-domain-containing-diguanylate-cyclase
MGEDGRLTAVVALAQGMAAAHTPRESWRAAALGACRALGGSFAALSVWERELGRLRVLVNVGDRARGEEEFPGDETYPVHQFPEITEFLHERWVAGGEPNAWVETAEGPAAGQPGYCHQRVAALRRRGRGCCVVAPIVLNGRAWGELYVARSAGVPVFDRGDADFATVLASVVAAGLAQSERLEEARRLAFTDALTGLANRRAVDVRLEEAIERHRDQGVVVSLVVCDLNGLKNVNDTRGHAVGDRLLERFGSVLSLCGAMLPGALAARLGGDEFCLLVVGSPADDVVKAADELCRRAAELELGEGVACGVASTEDPIGPVRSARRLFRLADAAQYQAKAVRADRPVVAGREGEDDPVVRLADAEPSGEDAVERRRFRGRLP
>NZ_CP028492.1|WP_107903728.1|953278_954022_+|hypothetical-protein
MRVAATVAVSALSLALVTGCGGDSGGSDAKALSAAELKKSVIAQGDVEGYKVDASGKQLPKSKDQVKSGEEKCAPLAYAMGGRAPGEAASETSVMVTQEKKKPTDGASKLEDLTESEIEDSITSAMDMTLTVVGLSSYDGDGAEETFKSVSDAVESCSGGFPVTMQGTDQKVTGIAAEKGSGSGDESVGFTAKSDAEDGDVATTHVEVVRHGSTIATYYTMNLGLMITDKPYDVPAAVIDAQSAKLK
>NZ_CP028492.1|WP_107905241.1|952921_953218_+|LPXTG-cell-wall-anchor-domain-containing-protein
MLTATAAGALLGALWFVPSANATGDEPAGADPSATPTTQVTQQARAASESTDGSTADDTRLADTGSFDTTPYVIGGTLFLSLGAGFIAYSVRRERLGF
>NZ_CP028492.1|WP_107903725.1|952416_952770_-|hypothetical-protein
MSTPETSRFVRLRVELVLEVDDADAVTTAALRRIADDSTVPVDERVHAESAVTEDTAEAVAYLVDPFDLVSEVPGVELVQASWSSERIEYDPDSPDWDLDEDDGEEDFDGEGAARVG
>NZ_CP028492.1|WP_107905240.1|950952_952194_-|hypothetical-protein
MTNSRRRKGLTVASALLGGVLALSACSSGGDASASDDDTSQAKVDEAAAKKTSEAQIKITPEDGSDNASINSSAVTVSKGSLTEVKMTTADGAAVEGQISADKASWKPSAQLERSTTYKVAVTAKDSKGLEAHENASFTTVSPNNSFLGYFTPEDGSTVGVGMPVSINFDKSISNKAAVQKGVTVTSTSGQEVACHWFNDTRMDCRPDEYWQEGSTVTLKLALDGVEGAKGVYGVQEKTVTFKIGRNQVSYVDAKTKQMKVTQDGKTVKTIPISAGSPENKTYQGVMVMSEKFKETRMNGATVGFTDDDGKGEYDIKDVPHAIRLSSSGTFIHGNYWGAKSIFGSVNTSHGCVGLSDTKGANDKGTAGYWFFNNSIVGDVVVVKNTGDKTIAPDNGLNGWNMDWAQWKAGSAV
>NZ_CP028492.1|WP_107903723.1|948408_949092_-|ABC-transporter-ATP-binding-protein
MYELRNVTKRYTRGKETINALDGVDLTIADGDRLVIQGPTGGGKSTLLQMLGGLDRPTSGEVVLDGTDLAKLPEARLTRVRSESIGFVFQSFNLIPTLTAQENVETALVPLGIKAKQRRERAAEALKSVGLGERLTHLPSEMSGGQQQRVAIARALVKEPKVLLADEPTGNLDESMRDEIMDVLERMWKELGLTFIMVTHDSAIAKKAPRLATIRKGRISVKENAGA
>NZ_CP028492.1|WP_107903721.1|944900_948140_-|peptidase-S8
MTSPASAEPEQRPTGAAASLTSPHRITLITGDRVSVDSKGRVVGLERAKGREHIPVQIRQAYGHTLVIPADAARLLAGGKLDQRLFDITELSRSATRTSQAKGLKVIVGYQGAAAGAKADVRDAGKLRRTLKSLNADAVQTPHQDTPELWDALTNGDRTASGIAHVWLDGVRKASLDKSVPQIGAPKAWAAGYDGKGVKIAVLDTGVDATHPDLKDQVIAAKNFTPAATAEDKVGHGTHVASIAAGTGAKSGGKYKGVAPGADILNGKVLDDTGSGDDSGILAGMEWAAEQGAQVVNLSLGGMDTPEIDPLEAAVNKLSADKGILFAIAAGNSGPETVGSPGSAEAALTVGAVDDKDALAPWSSTGPRVGDGAIKPDVTAPGVAITAAAAKGSLIAQEVGENPPGYLTIEGTSMATPHVAGAAAILKQQHPDWTYAELKGALTGSAKGGKYTPFQQGSGRIQVDKAIKQSVIAEPGSVSFGTQQWPHTDDKPVTKQLTYRNLGTKDVTLQLTATATNPGGQAAPAGFFKLAATKVTVPAGGKASVGFTVDTKLGGTVDGAYSAYVTATGGGQSVRTGAAVQRELESYDVTVKHIGRDGKPAPEYNTALLGFSGLAANRGYQVPLAESGVTKMRLPKGSYLLDAWIAKDWVNLEGGLDWLVQPKLNVTRNTSVTIDARTTKSADITVPDAQAKQVIASSNYFYDPAGIGIGVGLDSYANLRMAHLGPEVPTGLTQTWNGQWTKGAGAEYDVATTAKVKKIQGDKVRHFKAAELAKVTNNLGASSSNKTGALLPLGVFPDDVVFSSPIEQKLTGARTLYLSTSEKIQWTFDFEQHAGVDAEGFPIIDAYYTLGNPQTFKAGQSYTKTFNTAVFGPHINKDFGLFREGNDIYGFLPLFADGSKHAGSSEFSAVSTSLYRNGTRLATNDDPLFGEQMFRVPAGDAEYKLTTSVKRSVKVAAASTRIDASWTFRSKRSAAEQVRLPASTVRFDAKTGLDSRVEADKKVTFPVTVVGSAAGANLKSLHVYVSYDYGQTWKKLEVKNGKITVKNPAKGKAISFHAKVADKKGNKATVSIYNAYYGK
>NZ_CP028492.1|WP_107903719.1|943989_944760_-|antibiotic-biosynthesis-monooxygenase
MTAHTVEYIRYRIPEQKSAEFLAAYTRAAAQLAASPHCMDYELARCEEDFEHFVLRITWTSTEDHLEGFRKSELFPDFLAEIRPYITHIEEMRHYKPTAIRGAGASVPTLYAWAGGAEAFSRLTSAFYDKVLKDDLLAPLFEGLDPHHAEHVALWLGEVFGGPPAYSETQGGHGHMVAKHMGRGITEPQRRRWVNLIQDAADEAGLPTDAEFRSAFLAYVEWGTRLAVYFSGPDAVPPAEQPVPRWNWGAAPPYQG
>NZ_CP028492.1|WP_107903736.1|959138_960269_-|adenylate/guanylate-cyclase-domain-containing-protein
MTVDDSGSGTGADGRVDPNAADPGGDPLALRLEQLILGAERRYTPFQAARSAGVSMELASRFWRAMGFADIGQAKALTEADVLALRRLAGLVEAGLLSEAMAVQVARSTGQTTARLAEWQIDSFLEGLTEPPEPGMTRTEVTYPIIELLLPELEEFLVYVWRRQLAASAGRVIQAADDEEMVDRRLAVGFADLVGFTRLTRRMEEEELGELVEAFETTAADLVAARGGRLIKTLGDEVLYAADDAGVAAEIALRLIETMANDETMPELRVGIAFGTVTTRMGDVFGTTVNLASRLTSIAPRDAVLVDTAFAEELIRTGEAPASEAEAAEAAATAEKEGEEPPVYRFALQPMWQRPVRGLGVVEPWLLTRRASSDGE
>NZ_CP028492.1|WP_107903739.1|960465_961326_-|biotin--[acetyl-CoA-carboxylase]-ligase
MTPRDASDDSRWSDLERPPLNIAALRRGLVREGGLWRRVEVVERTGSTNTDLVDLATAGKAEEGTVLVAEEQTAGRGRLDRNWTAPPRSGLFFSVLLNPSEVPVTRWGWLPLLTGVAVATGLSRAAGVDTALKWPNDVLVTVGGEERKTGGILAERAGEAGVVIGVGINVTLRADELPVPQAASLVLAGAASTDRDPLLRGMLRSLEDWYGRWRAAVGDPLVSGLQETYAAGCATLGKTVRAELPGDRAITGEAVAIDGDGRLVLATEEGVQEPVGAGDIVHLRPA
>NZ_CP028492.1|WP_107903741.1|961436_963068_+|acyl-CoA-carboxylase-subunit-beta
MSEPEERHEIQGTPGIDIHTTAGKLADLQRRIEEATHAGSARAVEKQHAKGKLTARERVELLLDEGSFVELDEFARHRSTNFGLEKNRPYGDGVVTGYGTVDGRPVAVFSQDFTVFGGALGEVYGQKIVKVMDFALKTGCPVIGINDSGGARIQEGVASLGAYGEIFRRNTHASGVIPQISLVVGPCAGGAVYSPAITDFTVMVDQTSHMFITGPDVIKTVTGEDVGFEELGGARTHNSTSGVAHHMAGDEKDAIEYVKQLLSYLPSNNLSEPPVFEEEADLALTDEDRELDTIVPDSANQPYDMHAVIEHILDDAEFFETQPLFAPNIITGFGRVEGRPVGIVANQPMQFAGCLDIDASEKAARFVRTCDAFNVPVLTFVDVPGFLPGVDQEHTGIIRRGAKLIYAYAEATVPLITIITRKAFGGAYDVMGSKHLGADINLAWPTAQIAVMGAQGAVNILHRRTLAEAEAGGENPENAEAVRARLIREYEDALLNPYVAAERGYIDAVIMPSETRRHVVRGLRQLRTKRASLPPKKHGNIPL
>NZ_CP028492.1|WP_107903743.1|963085_963295_+|acyl-CoA-carboxylase-subunit-epsilon
MNIKVLRGNPTPEELAAALAVVRARAAAEAAIPPGAPKPRDGWSDPSRIARRRLPQPGPATWARTYWPG
>NZ_CP028492.1|WP_107903745.1|963291_964422_-|SGNH/GDSL-hydrolase-family-protein
MFTASWTASPQRPSEGFTPNWSREGFWRQSLRQVVRLSAGGGLVRVRLSNAYGESPVRVAGASVGRAGEGAAVRPGSLTPLTFGGAAGVAIPARGEVVSDAVRLAVAAGESVAVTLYFDAATGPATFHAQAFASGHRGEGDLSQASGGEGFDAVSESWYFLSAVETDAGRADAVALLGDSITDGFGSTVGADRRWSDALAKRTGRPVLNAGIGGNLLLNDSAWYGDGGVRRLRRDVLGLPGVDTLVVLLGLNDIGFSETDEQPTYKPAPVVEAAELIAGHRELLRQGRTAGLRVVGGTLLPLGGSDHWGEHAAKVSHELNEWIRCAGEYDAVVDLNRALADPEDPDRLRPAYDFGDHLHPNDAGYEVMAEVLAIAL
>NZ_CP028492.1|WP_107903748.1|964702_965323_+|septum-formation-inhibitor-Maf
MTDQPRRRLVLASQSPARLNLLRQAGLAPEVIVSGVDEDAVSAPTPAELALALAEAKASVVAARPEVKGAIVIGCDSVLDLDGEALGKPADAEEATARWKSMRGRAGTLQTGHCVYDTLSGRYTSATASTVVRFGEPTDEEIAAYVASGEPLYVAGAFTLDGRSAPFIDGIDGDHGNVIGISLPLVRRLLAQLGIGITELWEPAEG
>NZ_CP028492.1|WP_107903750.1|965291_965822_-|hypothetical-protein
MVRRPVAWLVAVVLFVEAFGIAALNWFLGVVVDRQDMSLAGLDPDVMSVSSKVGGLVFGGYFALCGLVALLVALRDRAPAGLGRILLISAAVVHGLLGAFAWGLVGWTAFVFMIVVLGLIVLLLMTYDGQSAPGRPADAAPDGGKGGDGSPVDGSPAGSSPAGGSPVTPPPAPTTP
>NZ_CP028492.1|WP_107903752.1|966183_967956_+|ATP-grasp-domain-containing-protein
MRKVLIANRGEIAVRVARACRDAGIASVAVYADPDRDALHVRAADEAFALGGDTPATSYLDIGKVLTAARESGADAIHPGYGFLSENADFAQAVLDADLIWIGPPPQAIRDLGDKVAARHIAQRAGAPLVAGTPDPVAGADEVVAFAEQHGLPIAIKAAFGGGGRGLKVARTLDEVPELYESAVREAVAAFGRGECFVERYLDKPRHVETQCLADTHGNVVVVSTRDCSLQRRHQKLVEEAPAPFLSEAQVAELYSSSKAILKEAGYVGAGTVEFLVGADGTISFLEVNTRLQVEHPVTEEVAGIDLVREMFRIADGEALGYDDPALRGHSFEFRINGEDPGRGFLPAPGTVTAFAPPSGPGVRLDAGVESGSVIGPAWDSLLAKLIVTGATREQALQRASRALEEFQVEGMATAIPFHRAVVKDPAFAPELTGSTDPFTVHTRWIETEFVNDIKPFAAPADTDADEDTGRETVVVEVGGKRLEVSLPASLGMTLARTGLAAGAKPKRRAAKKSGPVASGDTLASPMQGTIVKVAVEEGQEIKEGDLVVVLEAMKMEQPLNAHRSGTIKGLSAEVGASLTSGAAICEIKD
>NZ_CP028492.1|WP_107905242.1|968252_968801_+|TetR/AcrR-family-transcriptional-regulator
MRADARRNHERLLTEARSAFAEHGTDASLEDVARRAGVGIGTLYRHFPNRDALLSAVFEEAAGDLLARSRELLRSREPCAALMTWLREMVTHAGEYRGLARSLMSVSDDDTSALARCSGPIRQAGGALLSRAQEAGTVRPDVAVTDLLQLTHAIALAAEQTPDDPDLADRLLHLTLRGLKAP
>NZ_CP028492.1|WP_093747101.1|968899_969856_-|DeoR/GlpR-transcriptional-regulator
MFAAERRQLILEMVRANGAVSLRELARVVQTSEVTVRRDVRALEAEGLLDRRHGGAVLPGGFTRESGFPQKSHLATAEKTAIADLAANFVEEGEAIVVGAGTTTQELARRLARVPGLTVVTNSLLVAQALAHANRVEVVMTGGTLRGSNYALVGSGAEQSLQGLRVSRAFLSGSGLTAERGLSTSNMLSASVDRALVQAAAEVVVLADHTKLGTDTMFQTVPTDVITRLVTDEPPAHDDRAHTELQALADQGVQIAVAGASGASGGDEVPARRQQRALPGPRRGPSGGGPGLRPAGAAVLGEQGAERERARVADLRRR

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Crispr_ID: NZ_CP028492_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028492_2

973038-973139

Orphan

Consensus_repeat	Method
GTCGCGCAGTTCCCCGCGCCCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028492_2

>merge|NZ_CP028492|2|973038-973139|CRISPRCasFinder
GTCGCGCAGTTCCCCGCGCCCCTAAAGGCAGGGGGTTGCAGTGGGCCTGCGCCAAGCCGTGACCGCAACCGTCACAACCGTCGCGCAGTTCCCCGCGCCCCT

>NZ_CP028492|2|2|973038-973139|CRISPRCasFinder
GTCGCGCAGTTCCCCGCGCCCCT	AAAGGCAGGGGGTTGCAGTGGGCCTGCGCCAAGCCGTGACCGCAACCGTCACAACC
GTCGCGCAGTTCCCCGCGCCCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028492.1\|WP_037867721.1\|981797_982475_+\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_CP028492.1\|WP_107903750.1\|965291_965822_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_093747101.1\|968899_969856_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP028492.1\|WP_107905245.1\|976065_977025_+\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|188646
NZ_CP028492.1\|WP_030956459.1\|972148_972973_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NZ_CP028492.1\|WP_107903754.1\|970034_971483_-\|NAD(P)H-quinone-dehydrogenase	unknown	unknown	gnl\|CDD\|236112
NZ_CP028492.1\|WP_107903759.1\|978458_979358_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|365919
NZ_CP028492.1\|WP_107903762.1\|980248_980605_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_107903766.1\|984042_984648_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_107905244.1\|975170_975857_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|371225
NZ_CP028492.1\|WP_107905243.1\|971579_972017_+\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|372719
NZ_CP028492.1\|WP_107903745.1\|963291_964422_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238868
NZ_CP028492.1\|WP_107903756.1\|973399_975031_+\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_CP028492.1\|WP_107903743.1\|963085_963295_+\|acyl-CoA-carboxylase-subunit-epsilon	unknown	unknown	gnl\|CDD\|379386
NZ_CP028492.1\|WP_107903752.1\|966183_967956_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP028492.1\|WP_107903768.1\|985064_985616_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_CP028492.1\|WP_107903760.1\|979491_980178_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|223645
NZ_CP028492.1\|WP_107903748.1\|964702_965323_+\|septum-formation-inhibitor-Maf	unknown	unknown	gnl\|CDD\|178901
NZ_CP028492.1\|WP_107905242.1\|968252_968801_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP028492.1\|WP_107903764.1\|982471_984043_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715

Protein	Function_ID	Function_description	E-value
NZ_CP028492.1\|WP_037867721.1\|981797_982475_+\|DNA-binding-response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.57745e-80
NZ_CP028492.1\|WP_107903768.1\|985064_985616_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	6.52192e-22
NZ_CP028492.1\|WP_093747101.1\|968899_969856_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.9381e-81
NZ_CP028492.1\|WP_107905245.1\|976065_977025_+\|deoxyribose-phosphate-aldolase	gnl\|CDD\|188646	cd00959, DeoC, 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. DERA belongs to the class I aldolases and catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. DERA is unique in catalyzing the aldol reaction between two aldehydes, and its broad substrate specificity confers considerable utility as a biocatalyst, offering an environmentally benign alternative to chiral transition metal catalysis of the asymmetric aldol reaction.	7.99456e-76
NZ_CP028492.1\|WP_030956459.1\|972148_972973_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	8.22671e-136
NZ_CP028492.1\|WP_107903754.1\|970034_971483_-\|NAD(P)H-quinone-dehydrogenase	gnl\|CDD\|236112	PRK07845, PRK07845, flavoprotein disulfide reductase; Reviewed.	0
NZ_CP028492.1\|WP_107903759.1\|978458_979358_+\|aldehyde-dehydrogenase	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	1.49969e-42
NZ_CP028492.1\|WP_107905244.1\|975170_975857_-\|PH-domain-containing-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	8.67202e-05
NZ_CP028492.1\|WP_107905243.1\|971579_972017_+\|gamma-glutamylcyclotransferase	gnl\|CDD\|372719	pfam13772, AIG2_2, AIG2-like family. This family is found in bacteria and metazoa.	3.87517e-27
NZ_CP028492.1\|WP_107903745.1\|963291_964422_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.60584e-82
NZ_CP028492.1\|WP_107903756.1\|973399_975031_+\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP028492.1\|WP_107903743.1\|963085_963295_+\|acyl-CoA-carboxylase-subunit-epsilon	gnl\|CDD\|379386	pfam13822, ACC_epsilon, Acyl-CoA carboxylase epsilon subunit. This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes.	1.41783e-09
NZ_CP028492.1\|WP_107903752.1\|966183_967956_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP028492.1\|WP_107903760.1\|979491_980178_+\|uridine-kinase	gnl\|CDD\|223645	COG0572, Udk, Uridine kinase [Nucleotide transport and metabolism].	1.57579e-13
NZ_CP028492.1\|WP_107903748.1\|964702_965323_+\|septum-formation-inhibitor-Maf	gnl\|CDD\|178901	PRK00148, PRK00148, Maf-like protein; Reviewed.	1.11333e-95
NZ_CP028492.1\|WP_107905242.1\|968252_968801_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.50293e-11
NZ_CP028492.1\|WP_107903764.1\|982471_984043_+\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	6.59594e-52

>NZ_CP028492.1|WP_030956459.1|972148_972973_+|purine-nucleoside-phosphorylase
MNASLLPDDIQGDPHAAADAAAARLRELTGAETHDVALVMGSGWAPAVDALGAPEAEFQVTELPGFPPPAVEGHGGKVRSYRIGNKRALVFLGRTHYYEGRGVAAVSHGVRTAVAAGCKTIVLTNGCGGLREGMRPGQPVLISDHINLTATSPIIGANFVDLTDLYSPRLRALCKEIDPTLEEGVYAQFPGPHYETPAEIRMARVIGADLVGMSTVLEAIAAREAGAEVLGISLVTNLAAGMTGEPLNHEEVLQAGRDSATQMGSLLAQVLGRL
>NZ_CP028492.1|WP_107905243.1|971579_972017_+|gamma-glutamylcyclotransferase
MSLYAAYAGNLDARLMTRRAPHSPLRATGWLNGWRLTFGGEQLGWEGALATLVEDPMEQVFVALYDIAPMDEDSLDRWEGVGLGIYRRLRVRVHTLEGEEPAWTYVLNAYEGGLPSARYLGEVADAAESAGAPHDYVMELRKRPC
>NZ_CP028492.1|WP_107903754.1|970034_971483_-|NAD(P)H-quinone-dehydrogenase
MEYVTRIVIIGGGPGGYEAALVAAQLGAEVTVVDCDGLGGASVLTDCVPSKTLIATAEVMTTFDSSYEELGIIVADDTPHIDTPARVVGVDLGKVNRRVKRLALAQSHDITASVTRAGARVMRGRGRLEGMQGLDGSRKVVVRAADGTEETLVADAVLIATGGHPRELPDAQPDGERILNWTQVYDLNELPEELIVVGSGVTGAEFAGAYQALGSRVTLVSSRDRVLPGEDPDAAAVLEDVFRRRGMNVMARSRAAAAKRVGDRVEVTLADGRVISGTHCLMAVGAIPNSEGMGLEEAGVKLRDSGHIWTDKVSRTSAPGVYAAGDVTGVFALASVAAMQGRIAMYHFLGDAVAPLNLKTVSSNVFTDPEIATVGYSQADVDAGKIDARVVKLPLLRNPRAKMQGIRDGFVKIFCRPGTGIVVGGVVVSPRASELIHPISIAVDNNLTVEQIANAFTVYPSLSGSIAEVARQLHTRKSGGEL
>NZ_CP028492.1|WP_093747101.1|968899_969856_-|DeoR/GlpR-transcriptional-regulator
MFAAERRQLILEMVRANGAVSLRELARVVQTSEVTVRRDVRALEAEGLLDRRHGGAVLPGGFTRESGFPQKSHLATAEKTAIADLAANFVEEGEAIVVGAGTTTQELARRLARVPGLTVVTNSLLVAQALAHANRVEVVMTGGTLRGSNYALVGSGAEQSLQGLRVSRAFLSGSGLTAERGLSTSNMLSASVDRALVQAAAEVVVLADHTKLGTDTMFQTVPTDVITRLVTDEPPAHDDRAHTELQALADQGVQIAVAGASGASGGDEVPARRQQRALPGPRRGPSGGGPGLRPAGAAVLGEQGAERERARVADLRRR
>NZ_CP028492.1|WP_107905242.1|968252_968801_+|TetR/AcrR-family-transcriptional-regulator
MRADARRNHERLLTEARSAFAEHGTDASLEDVARRAGVGIGTLYRHFPNRDALLSAVFEEAAGDLLARSRELLRSREPCAALMTWLREMVTHAGEYRGLARSLMSVSDDDTSALARCSGPIRQAGGALLSRAQEAGTVRPDVAVTDLLQLTHAIALAAEQTPDDPDLADRLLHLTLRGLKAP
>NZ_CP028492.1|WP_107903752.1|966183_967956_+|ATP-grasp-domain-containing-protein
MRKVLIANRGEIAVRVARACRDAGIASVAVYADPDRDALHVRAADEAFALGGDTPATSYLDIGKVLTAARESGADAIHPGYGFLSENADFAQAVLDADLIWIGPPPQAIRDLGDKVAARHIAQRAGAPLVAGTPDPVAGADEVVAFAEQHGLPIAIKAAFGGGGRGLKVARTLDEVPELYESAVREAVAAFGRGECFVERYLDKPRHVETQCLADTHGNVVVVSTRDCSLQRRHQKLVEEAPAPFLSEAQVAELYSSSKAILKEAGYVGAGTVEFLVGADGTISFLEVNTRLQVEHPVTEEVAGIDLVREMFRIADGEALGYDDPALRGHSFEFRINGEDPGRGFLPAPGTVTAFAPPSGPGVRLDAGVESGSVIGPAWDSLLAKLIVTGATREQALQRASRALEEFQVEGMATAIPFHRAVVKDPAFAPELTGSTDPFTVHTRWIETEFVNDIKPFAAPADTDADEDTGRETVVVEVGGKRLEVSLPASLGMTLARTGLAAGAKPKRRAAKKSGPVASGDTLASPMQGTIVKVAVEEGQEIKEGDLVVVLEAMKMEQPLNAHRSGTIKGLSAEVGASLTSGAAICEIKD
>NZ_CP028492.1|WP_107903750.1|965291_965822_-|hypothetical-protein
MVRRPVAWLVAVVLFVEAFGIAALNWFLGVVVDRQDMSLAGLDPDVMSVSSKVGGLVFGGYFALCGLVALLVALRDRAPAGLGRILLISAAVVHGLLGAFAWGLVGWTAFVFMIVVLGLIVLLLMTYDGQSAPGRPADAAPDGGKGGDGSPVDGSPAGSSPAGGSPVTPPPAPTTP
>NZ_CP028492.1|WP_107903748.1|964702_965323_+|septum-formation-inhibitor-Maf
MTDQPRRRLVLASQSPARLNLLRQAGLAPEVIVSGVDEDAVSAPTPAELALALAEAKASVVAARPEVKGAIVIGCDSVLDLDGEALGKPADAEEATARWKSMRGRAGTLQTGHCVYDTLSGRYTSATASTVVRFGEPTDEEIAAYVASGEPLYVAGAFTLDGRSAPFIDGIDGDHGNVIGISLPLVRRLLAQLGIGITELWEPAEG
>NZ_CP028492.1|WP_107903745.1|963291_964422_-|SGNH/GDSL-hydrolase-family-protein
MFTASWTASPQRPSEGFTPNWSREGFWRQSLRQVVRLSAGGGLVRVRLSNAYGESPVRVAGASVGRAGEGAAVRPGSLTPLTFGGAAGVAIPARGEVVSDAVRLAVAAGESVAVTLYFDAATGPATFHAQAFASGHRGEGDLSQASGGEGFDAVSESWYFLSAVETDAGRADAVALLGDSITDGFGSTVGADRRWSDALAKRTGRPVLNAGIGGNLLLNDSAWYGDGGVRRLRRDVLGLPGVDTLVVLLGLNDIGFSETDEQPTYKPAPVVEAAELIAGHRELLRQGRTAGLRVVGGTLLPLGGSDHWGEHAAKVSHELNEWIRCAGEYDAVVDLNRALADPEDPDRLRPAYDFGDHLHPNDAGYEVMAEVLAIAL
>NZ_CP028492.1|WP_107903743.1|963085_963295_+|acyl-CoA-carboxylase-subunit-epsilon
MNIKVLRGNPTPEELAAALAVVRARAAAEAAIPPGAPKPRDGWSDPSRIARRRLPQPGPATWARTYWPG
>NZ_CP028492.1|WP_107903756.1|973399_975031_+|phospho-sugar-mutase
MHDDLITRAKAWLEEDPDPETRAELAKLIDAADVTELAPRFSGTLQFGTAGLRGELGAGPMRMNRTVVIRAAAGLAAYLKSQGHTDGLVVIGYDARHKSEDFARDTAAVMTGAGLRAAVLPRPLPTPVLAYAIRHLGAAAGVEVTASHNPPRDNGYKVYLGDGSQIVPPADADIAAEIDAVRSLNDVPRPDSGWETLDDSVLDAYLARTDEVLAAGSPRTARTVYTAMHGVGKDVLLAAFERAGFPAPALVAEQADPDPDFPTVAFPNPEEPGAMDLAFAKARETDPDLVIANDPDADRCAVAVKEDAEWRMLRGDEVGSLLAAHLVGRGARGTFAESIVSSSLLGRIAEKAGLPYEETLTGFKWIARVDGLRYGYEEALGYCVDPEGVRDKDGITAALLITELASALKEEGRTLLDLLDDLAVEHGLHATDQLSVRVEDLSVITDAMRRLREQPPTELAGLAITRAEDLTRGTETLPPTDGLRYTLEGARVIVRPSGTEPKLKCYLEVVVPVAKHADLPAARAEAAGLLATIKRDLSTAAGI
>NZ_CP028492.1|WP_107905244.1|975170_975857_-|PH-domain-containing-protein
MTTPEHPSPSPDPTSKDRVYRSPMGIVGGVALLVIVLWLGFDALLRGEGRTQWLALAAIILLVPLVIAFTLRPAVHANEDRLRIRNPLRVIVLPWGQVAALRSSYSNEVVAKSGTKFQLWAVPVSLRARKKAARRSARAASGRGDRGGRMGGGAGFGGLGFGAPRGDVDSDGPMRAETDKIMDDLRELLEQGENSESAQGEVTVRWAYEVAGPVVAGAVLLVILLAIG
>NZ_CP028492.1|WP_107905245.1|976065_977025_+|deoxyribose-phosphate-aldolase
MPTNASAAAHALTDVTASDSTLRRFLHGLPGVDAVGLEGRAASLGTRSIKTTAKAYAIDLAISMVDLTTLEGADTPGKVRALGAKAVHPDPTDRTTPSTAAVCVYPDMVATAKAAVAGSTVKVASVATAFPAGRAPLAVKLADVREAVAAGADEIDMVIDRGAFLAGNYMKVYDEIVAVKEASGAARLKVIFETGELSTYDNIRRASWLGMLGGADFIKTSTGKVAVNATPANTLLMLEAVRDFRAQTGIQVGVKPAGGIRTSKDAIKFLVLVNETAGEDWLDNHWFRFGASSLLNDLLMQRQKLATGRYSGPDYVTVD
>NZ_CP028492.1|WP_107903759.1|978458_979358_+|aldehyde-dehydrogenase
MSDKSEQQRLSVFKTYKLYVGGKFPRSESGRVYEVTDSKGNWLANVPLSSRKDARDAVVAARKAFGGWSGATAYNRGQILYRIAEMLEGRREQYVREVADAEGLSKSKAAAQVDAAIDRWVWYAGWTDKIAQVVGGGNPVAGPFFNLSSPEPTGVVAIVAPQESSFLGLVSVLAPVIATGNTAIVVASEKSPLPALSLGEVLATSDLPGGVVNVLSGRTAEIATPLAAHQDVNAIDLAGAGEDLAKELEIAAADNLKRVLRPQPVDHTATPGIDRMTAFLETKTVWHPTGSLGASGSSY
>NZ_CP028492.1|WP_107903760.1|979491_980178_+|uridine-kinase
MVRRVVHRPVDASHWCPVSSPSPIPTRVVLLCGPSGSGKSLLAARSGLPVLRLDDFYKEGDDPTLPLVPGSSDIDWDHPDSWDADTAVAAITELCRTGRTDVPLYDISLSARTGAESVDIGRTPLFIAEGIFAAEIVNRCRELGVLADALCLSRGPMRTFRRRFLRDLKEGRKSVPFLLRRGWRLMRLERSIVAHQTSLGAYACDRDEALGRLTAAAAGRCPATAPAA
>NZ_CP028492.1|WP_107903762.1|980248_980605_+|hypothetical-protein
MTGAPLTVRRVLPAVLLALAATGCGEGDATEPDGTAAASCAYMVTYADRTYLGTAGTDFTVGKKLGTATVPECDDTPNDPEGAVPEGKVTAYAVEGTDPAVAIAVGDTPAEVTLMKVR
>NZ_CP028492.1|WP_037867721.1|981797_982475_+|DNA-binding-response-regulator
MPSLLLIEDDDAIRTALELSLTRQGHRVATAATGEDGLKLLREQRPDLIVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARNDDIDIVVGLESGADDYIVKPVQGRVLDARIRAVLRRGERESNDAAAFGSLVIDRAAMTVTKNGEDLQLTPTELRLLLELSRRPGQALSRQQLLRLVWEHDYLGDSRLVDACVQRLRAKVEDVPSSPTLIRTVRGVGYRLDAPQ
>NZ_CP028492.1|WP_107903764.1|982471_984043_+|sensor-histidine-kinase
MTEAQGGFRGWFAARKGVWSRLRFTSLRLRLVVVFGLVALTAAVSASGIAYWLNREAVLTRTQDAVLRDFEQEMQNRAGLLPEEPTQDELQHTAGQMANSSQRFSVLLVAQDAAGAPAYGSSGGLDGFTLADVPKSLRTAVNEKQEVDSSNKAEYHLYWQRIVEDDTPYLIAGTKVNGGGPTGYMLKSLEQEAKDLNSLAWSLGIATGLALIGSALLAQAAATTVLKPVQRLGVAARRLGEGKLDTRLRVSGTDELADLSRTFNNAAAALEKRVADMASRDESSRRFVADMSHELRTPLTAITAVTEVLEEELEMESGSMDPMIEPAVRLVVSETRRLNDLVENLMEVTRFDAGTARLVLDHVDIADQITACIDARAWLDAVDLDAERGIMARLDPRRLDVILANLIGNALKHGGSPVRVAVRVTDDEIVIAVRDHGPGIPEDVLPHVFDRFYKASASRPRSEGSGLGLSIALENAHIHGGEITAANSPEGGAIFTLRLPRETSDAVASGDENPQHDPPKGDA
>NZ_CP028492.1|WP_107903766.1|984042_984648_+|hypothetical-protein
MKKRRLLTLTTLSAALLTGCGIRSTEVPTDFGPAPSRVHCSLSEPNISTQAERGLPVQVFLLCGSQLVAVDRTVRVPDGTADSARRVLVAQGLLDELEATPSATEKEAGYTTDVRGAMGVTGPRPADPDETLRLSTPPDDLTSYALAQIVCTFSDSSAAEGDGSVILGGPTRETPRRYECTNEVRTRPGSNEPPSTEVADG
>NZ_CP028492.1|WP_107903768.1|985064_985616_+|VanZ-family-protein
MQRQGSIGGSAAIRIRVTGGILLLAHLAFVAWLTLRPLDVPWVTPANLQPFAGIRADLALGWQEAARRIIEGLALLAPLGVLIPTAHGSLTASPLGSLVRTVAAGALISLGIELLQTGVPGQVVDVDSLLLNTLGVALAHAAIVPAARIHLRRRSERADRPAAPQDEPTQGRTPTIPRVGIAP

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Crispr_ID: NZ_CP028492_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028492_3

984684-984786

Orphan

Consensus_repeat	Method
TCGCGCAGTTCCCCGCGCCCCTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028492_3

>merge|NZ_CP028492|3|984684-984786|CRISPRCasFinder
TCGCGCAGTTCCCCGCGCCCCTAAAGGCAGGGGGTTGCAGCGGGCCTGCGCCGAGACGTGACCGCGAACGTCACAACCCTTCGCGCAGTTCCCCGCGCCCCTA

>NZ_CP028492|3|3|984684-984786|CRISPRCasFinder
TCGCGCAGTTCCCCGCGCCCCTA	AAGGCAGGGGGTTGCAGCGGGCCTGCGCCGAGACGTGACCGCGAACGTCACAACCCT
TCGCGCAGTTCCCCGCGCCCCTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028492.1\|WP_037867721.1\|981797_982475_+\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_CP028492.1\|WP_107903772.1\|986628_987792_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
NZ_CP028492.1\|WP_107903768.1\|985064_985616_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_CP028492.1\|WP_107905245.1\|976065_977025_+\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|188646
NZ_CP028492.1\|WP_107903764.1\|982471_984043_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP028492.1\|WP_107903759.1\|978458_979358_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|365919
NZ_CP028492.1\|WP_107903777.1\|992646_993567_+\|AEC-family-transporter	unknown	unknown	gnl\|CDD\|223751
NZ_CP028492.1\|WP_107905244.1\|975170_975857_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|371225
NZ_CP028492.1\|WP_107903775.1\|991171_992191_+\|RNA-polymerase-subunit-sigma-70	unknown	unknown	gnl\|CDD\|236196
NZ_CP028492.1\|WP_107903770.1\|986067_986490_-\|ATP-binding-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_107903766.1\|984042_984648_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_107903774.1\|987926_988688_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225496
NZ_CP028492.1\|WP_107903779.1\|993619_994903_-\|thymidine-phosphorylase	unknown	unknown	gnl\|CDD\|180276
NZ_CP028492.1\|WP_107903756.1\|973399_975031_+\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_CP028492.1\|WP_107903762.1\|980248_980605_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_093747093.1\|985724_985925_+\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
NZ_CP028492.1\|WP_107903760.1\|979491_980178_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|223645
NZ_CP028492.1\|WP_030967094.1\|994988_995396_-\|cytidine-deaminase	unknown	unknown	gnl\|CDD\|180142
NZ_CP028492.1\|WP_037866043.1\|988713_989667_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176125
NZ_CP028492.1\|WP_030956459.1\|972148_972973_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183

Protein	Function_ID	Function_description	E-value
NZ_CP028492.1\|WP_037867721.1\|981797_982475_+\|DNA-binding-response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.57745e-80
NZ_CP028492.1\|WP_107903772.1\|986628_987792_-\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	3.38265e-159
NZ_CP028492.1\|WP_107903768.1\|985064_985616_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	6.52192e-22
NZ_CP028492.1\|WP_107905245.1\|976065_977025_+\|deoxyribose-phosphate-aldolase	gnl\|CDD\|188646	cd00959, DeoC, 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. DERA belongs to the class I aldolases and catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. DERA is unique in catalyzing the aldol reaction between two aldehydes, and its broad substrate specificity confers considerable utility as a biocatalyst, offering an environmentally benign alternative to chiral transition metal catalysis of the asymmetric aldol reaction.	7.99456e-76
NZ_CP028492.1\|WP_107903764.1\|982471_984043_+\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	6.59594e-52
NZ_CP028492.1\|WP_107903777.1\|992646_993567_+\|AEC-family-transporter	gnl\|CDD\|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	5.93815e-42
NZ_CP028492.1\|WP_107905244.1\|975170_975857_-\|PH-domain-containing-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	8.67202e-05
NZ_CP028492.1\|WP_107903775.1\|991171_992191_+\|RNA-polymerase-subunit-sigma-70	gnl\|CDD\|236196	PRK08241, PRK08241, RNA polymerase subunit sigma-70.	0
NZ_CP028492.1\|WP_107903774.1\|987926_988688_+\|alpha/beta-hydrolase	gnl\|CDD\|225496	COG2945, COG2945, Predicted hydrolase of the alpha/beta superfamily [General function prediction only].	0.000356521
NZ_CP028492.1\|WP_107903779.1\|993619_994903_-\|thymidine-phosphorylase	gnl\|CDD\|180276	PRK05820, deoA, thymidine phosphorylase; Reviewed.	0
NZ_CP028492.1\|WP_107903756.1\|973399_975031_+\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP028492.1\|WP_107903759.1\|978458_979358_+\|aldehyde-dehydrogenase	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	1.49969e-42
NZ_CP028492.1\|WP_093747093.1\|985724_985925_+\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	7.58806e-20
NZ_CP028492.1\|WP_107903760.1\|979491_980178_+\|uridine-kinase	gnl\|CDD\|223645	COG0572, Udk, Uridine kinase [Nucleotide transport and metabolism].	1.57579e-13
NZ_CP028492.1\|WP_030967094.1\|994988_995396_-\|cytidine-deaminase	gnl\|CDD\|180142	PRK05578, PRK05578, cytidine deaminase; Validated.	5.95283e-73
NZ_CP028492.1\|WP_037866043.1\|988713_989667_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.36791e-88
NZ_CP028492.1\|WP_030956459.1\|972148_972973_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	8.22671e-136

>NZ_CP028492.1|WP_107903766.1|984042_984648_+|hypothetical-protein
MKKRRLLTLTTLSAALLTGCGIRSTEVPTDFGPAPSRVHCSLSEPNISTQAERGLPVQVFLLCGSQLVAVDRTVRVPDGTADSARRVLVAQGLLDELEATPSATEKEAGYTTDVRGAMGVTGPRPADPDETLRLSTPPDDLTSYALAQIVCTFSDSSAAEGDGSVILGGPTRETPRRYECTNEVRTRPGSNEPPSTEVADG
>NZ_CP028492.1|WP_107903764.1|982471_984043_+|sensor-histidine-kinase
MTEAQGGFRGWFAARKGVWSRLRFTSLRLRLVVVFGLVALTAAVSASGIAYWLNREAVLTRTQDAVLRDFEQEMQNRAGLLPEEPTQDELQHTAGQMANSSQRFSVLLVAQDAAGAPAYGSSGGLDGFTLADVPKSLRTAVNEKQEVDSSNKAEYHLYWQRIVEDDTPYLIAGTKVNGGGPTGYMLKSLEQEAKDLNSLAWSLGIATGLALIGSALLAQAAATTVLKPVQRLGVAARRLGEGKLDTRLRVSGTDELADLSRTFNNAAAALEKRVADMASRDESSRRFVADMSHELRTPLTAITAVTEVLEEELEMESGSMDPMIEPAVRLVVSETRRLNDLVENLMEVTRFDAGTARLVLDHVDIADQITACIDARAWLDAVDLDAERGIMARLDPRRLDVILANLIGNALKHGGSPVRVAVRVTDDEIVIAVRDHGPGIPEDVLPHVFDRFYKASASRPRSEGSGLGLSIALENAHIHGGEITAANSPEGGAIFTLRLPRETSDAVASGDENPQHDPPKGDA
>NZ_CP028492.1|WP_037867721.1|981797_982475_+|DNA-binding-response-regulator
MPSLLLIEDDDAIRTALELSLTRQGHRVATAATGEDGLKLLREQRPDLIVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARNDDIDIVVGLESGADDYIVKPVQGRVLDARIRAVLRRGERESNDAAAFGSLVIDRAAMTVTKNGEDLQLTPTELRLLLELSRRPGQALSRQQLLRLVWEHDYLGDSRLVDACVQRLRAKVEDVPSSPTLIRTVRGVGYRLDAPQ
>NZ_CP028492.1|WP_107903762.1|980248_980605_+|hypothetical-protein
MTGAPLTVRRVLPAVLLALAATGCGEGDATEPDGTAAASCAYMVTYADRTYLGTAGTDFTVGKKLGTATVPECDDTPNDPEGAVPEGKVTAYAVEGTDPAVAIAVGDTPAEVTLMKVR
>NZ_CP028492.1|WP_107903760.1|979491_980178_+|uridine-kinase
MVRRVVHRPVDASHWCPVSSPSPIPTRVVLLCGPSGSGKSLLAARSGLPVLRLDDFYKEGDDPTLPLVPGSSDIDWDHPDSWDADTAVAAITELCRTGRTDVPLYDISLSARTGAESVDIGRTPLFIAEGIFAAEIVNRCRELGVLADALCLSRGPMRTFRRRFLRDLKEGRKSVPFLLRRGWRLMRLERSIVAHQTSLGAYACDRDEALGRLTAAAAGRCPATAPAA
>NZ_CP028492.1|WP_107903759.1|978458_979358_+|aldehyde-dehydrogenase
MSDKSEQQRLSVFKTYKLYVGGKFPRSESGRVYEVTDSKGNWLANVPLSSRKDARDAVVAARKAFGGWSGATAYNRGQILYRIAEMLEGRREQYVREVADAEGLSKSKAAAQVDAAIDRWVWYAGWTDKIAQVVGGGNPVAGPFFNLSSPEPTGVVAIVAPQESSFLGLVSVLAPVIATGNTAIVVASEKSPLPALSLGEVLATSDLPGGVVNVLSGRTAEIATPLAAHQDVNAIDLAGAGEDLAKELEIAAADNLKRVLRPQPVDHTATPGIDRMTAFLETKTVWHPTGSLGASGSSY
>NZ_CP028492.1|WP_107905245.1|976065_977025_+|deoxyribose-phosphate-aldolase
MPTNASAAAHALTDVTASDSTLRRFLHGLPGVDAVGLEGRAASLGTRSIKTTAKAYAIDLAISMVDLTTLEGADTPGKVRALGAKAVHPDPTDRTTPSTAAVCVYPDMVATAKAAVAGSTVKVASVATAFPAGRAPLAVKLADVREAVAAGADEIDMVIDRGAFLAGNYMKVYDEIVAVKEASGAARLKVIFETGELSTYDNIRRASWLGMLGGADFIKTSTGKVAVNATPANTLLMLEAVRDFRAQTGIQVGVKPAGGIRTSKDAIKFLVLVNETAGEDWLDNHWFRFGASSLLNDLLMQRQKLATGRYSGPDYVTVD
>NZ_CP028492.1|WP_107905244.1|975170_975857_-|PH-domain-containing-protein
MTTPEHPSPSPDPTSKDRVYRSPMGIVGGVALLVIVLWLGFDALLRGEGRTQWLALAAIILLVPLVIAFTLRPAVHANEDRLRIRNPLRVIVLPWGQVAALRSSYSNEVVAKSGTKFQLWAVPVSLRARKKAARRSARAASGRGDRGGRMGGGAGFGGLGFGAPRGDVDSDGPMRAETDKIMDDLRELLEQGENSESAQGEVTVRWAYEVAGPVVAGAVLLVILLAIG
>NZ_CP028492.1|WP_107903756.1|973399_975031_+|phospho-sugar-mutase
MHDDLITRAKAWLEEDPDPETRAELAKLIDAADVTELAPRFSGTLQFGTAGLRGELGAGPMRMNRTVVIRAAAGLAAYLKSQGHTDGLVVIGYDARHKSEDFARDTAAVMTGAGLRAAVLPRPLPTPVLAYAIRHLGAAAGVEVTASHNPPRDNGYKVYLGDGSQIVPPADADIAAEIDAVRSLNDVPRPDSGWETLDDSVLDAYLARTDEVLAAGSPRTARTVYTAMHGVGKDVLLAAFERAGFPAPALVAEQADPDPDFPTVAFPNPEEPGAMDLAFAKARETDPDLVIANDPDADRCAVAVKEDAEWRMLRGDEVGSLLAAHLVGRGARGTFAESIVSSSLLGRIAEKAGLPYEETLTGFKWIARVDGLRYGYEEALGYCVDPEGVRDKDGITAALLITELASALKEEGRTLLDLLDDLAVEHGLHATDQLSVRVEDLSVITDAMRRLREQPPTELAGLAITRAEDLTRGTETLPPTDGLRYTLEGARVIVRPSGTEPKLKCYLEVVVPVAKHADLPAARAEAAGLLATIKRDLSTAAGI
>NZ_CP028492.1|WP_030956459.1|972148_972973_+|purine-nucleoside-phosphorylase
MNASLLPDDIQGDPHAAADAAAARLRELTGAETHDVALVMGSGWAPAVDALGAPEAEFQVTELPGFPPPAVEGHGGKVRSYRIGNKRALVFLGRTHYYEGRGVAAVSHGVRTAVAAGCKTIVLTNGCGGLREGMRPGQPVLISDHINLTATSPIIGANFVDLTDLYSPRLRALCKEIDPTLEEGVYAQFPGPHYETPAEIRMARVIGADLVGMSTVLEAIAAREAGAEVLGISLVTNLAAGMTGEPLNHEEVLQAGRDSATQMGSLLAQVLGRL
>NZ_CP028492.1|WP_107903768.1|985064_985616_+|VanZ-family-protein
MQRQGSIGGSAAIRIRVTGGILLLAHLAFVAWLTLRPLDVPWVTPANLQPFAGIRADLALGWQEAARRIIEGLALLAPLGVLIPTAHGSLTASPLGSLVRTVAAGALISLGIELLQTGVPGQVVDVDSLLLNTLGVALAHAAIVPAARIHLRRRSERADRPAAPQDEPTQGRTPTIPRVGIAP
>NZ_CP028492.1|WP_093747093.1|985724_985925_+|PspC-domain-containing-protein
MTALARPTNGRMIGGVCAALARRFGTSATTMRVIFLLSCLLPGPQFLLYIAMWILLPSENKTRTAW
>NZ_CP028492.1|WP_107903770.1|986067_986490_-|ATP-binding-protein
MKQSAAKTLGVAALGAAFAAAGAGAANAAPVAPDAAGSALDNVTRTLPAENLAQSAPGAGAGLAQGGAGLAQGQEALAAGLSAAQPAAEQAVAGGPTGVVAGLLGGLPVQGAAAEGLPVQGLPVQGLPTQGLPVNGLPLG
>NZ_CP028492.1|WP_107903772.1|986628_987792_-|adenosine-deaminase
MTSETAQKANTPSSDQIRRAPKVLLHDHLDGGLRPGTIVELARDTGYTHLPETDPDKLGVWFRDAADSGSLERYLETFSHTVGVMQTRDALVRVARECAEDLAEDGVVYAEVRYAPEQHLEGGLSLEEVVEAVNEGFREGELIARENGHRIRVGALLTAMRHAARALEIAELANRYRDLGVVGFDIAGAEAGHPPTRHLDAFEYLKRENNHFTIHAGEAFGLPSIWQALQWCGADRLGHGVRIIDDIQVHADGSVKLGRLASYVRDKRIPLELCPSSNLQTGAADSYAEHPIGLLRRLHFRATVNTDNRLMSHTSMSREFEHLVEAFGYTLDDMQWFSVNAMKSSFIPFDERLAMINDVIKPGYAELKSEWLFRQTSSTSDSAEEQG
>NZ_CP028492.1|WP_107903774.1|987926_988688_+|alpha/beta-hydrolase
MAQQATPVRRVRLGKAIGPEPTAVSGVVLLLPGGDETSHRKPAPLLATNYVRTLGRRLTRAGRDDGLATHVVRYRYRGWNGSAANLASDALWAADEAVRRYGDVPVCLVGVDMGARAALHAGGHEAVNSVLAIAPWLPEEDMAAAPEPVKQLAGRRVLFVHGTNDERTDPELSFRLAERAKKANRDVCRFEVHSDRHALHQHRDEVLALAQDFVMGVLFGRAFSRPVADAFAAPPPLGLRMPLASGFGKSLRR
>NZ_CP028492.1|WP_037866043.1|988713_989667_-|LysR-family-transcriptional-regulator
MEHQQRSRARLSPSSDTEDMTMLLAPRLAHFAGVARTEHVTRAAQEMRVPQSTLSRAMVRLEQDLGVDLFARHGRTVSLTPAGRTFLASVERALAEIGRAAEEVRADADPATGKVAFGFLHTMGAETVPGLIHAFRADHPRIRFSLVQNYGEAMIERLRSGELDLCLTSPVPDAPDLVARRLDEQKLRLVVPADHRLASRKRVRLAEAADETFVTLEPGYGMRRITDDLCQEAGFKPRIAFEGEEAETLRGLVAAGLGVALLPPPAVPRPGVVELTVTAPRAAREIGVAWLADRPDTPPVAAFKRFLLSRRGNLLPT
>NZ_CP028492.1|WP_107903775.1|991171_992191_+|RNA-polymerase-subunit-sigma-70
MSDGTATKTTDLDVRLEKHRVELTGYCYRMLGSSFEAEDAVQDTMVRAWRSYDKFEGRSSLRSWLYRIATNVCLDMLTAGNKRARPMDLTESTPLAQAALSPRPDNTWLEPMPDSRVLPSTEDPAEAAVAKESVRLAFMAALQQLPPKQRAVLILREVLAWRATEVAELLGTTVASVNSALQRARATLAEQQQPGAEATVSDPLDDEQQKLLDRYVAAFEGYDMTALTALLHEDAIMTMPPFDLWLTGHDDIAGFMTTLGSACEGSRLVPVEVNGLPGFAQYKPDPEAGGYTPWAVQVLEISDGRLTGFHFFLDTKRWFPLFGLPLHLEAETDQVEEGV
>NZ_CP028492.1|WP_107903777.1|992646_993567_+|AEC-family-transporter
MQGVLTGFAVIAVVIAVGYAIGRRGYLGDQGREVLTKLAFHVASPALLFTTLAQTDLSVIFSSRLLVTALSTAAAAGVFVAVGVVRHWGVGRTTIGALCSSYVNSGNLGIPIAVYVLGDASLVAPVLLFQLVGVTPVALTILDLSGKGEKGPLWRRLLTPLRNPIAVGSLAGVAVSATGLRIPAPVLDPLTLIGGMSVPAVLLAFGISLCGSTMPGRGPDRHPVFLSVALKSVGQPAAAWALAAGVFGLRGAPLLDVVVTSALPAAQNLYTYASSYRVAERLARDSILLSTVISVPVLVVVAALLG
>NZ_CP028492.1|WP_107903779.1|993619_994903_-|thymidine-phosphorylase
MAMDAISVIRTKRDRGELSDEQIDWVIDAYTRGEVADYQMAALNMAILLNGMNRREIARWTAAMIASGERMDFSSLSRPTADKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKLESIPGWRALLSNEEMLHVLDTTGAVICAAGDGLAPADKKLYALRDVTGTVEAIPLIASSIMSKKIAEGTGSLVLDVKVGTGAFMKTIEDARELASTMVGLGTDHGVKTVALLTDMATPLGLTAGNALEVRESVEVLAGGGPADVVELTIALAREMLDAAGVKDADPAKALADGSAMDVWRRMIAAQGGDPDAELPVAREQHVVKAPSSGVLTRLDAYDIGVAAWRLGAGRARKEDPVQAGAGIEMHAKPGDTVTEGQPLLTLHTDTPERFDYALQSLTESYDIAAPGTDFTASPVVLERIA
>NZ_CP028492.1|WP_030967094.1|994988_995396_-|cytidine-deaminase
MTPAASHDVDWDKLRAAALDAMSRAYAPYSGFPVGVAALVDDGRTITGCNVENASYGLALCAECGLVSELQNTGGGRLTHFTCVDGKGDVLVPCGRCRQLLFEFGGPELLLETPAGILPLSEMLPQAFGPGHLRK

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Crispr_ID: NZ_CP028492_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028492_4

2054452-2054555

Orphan

Consensus_repeat	Method
GGCGGCTACGGCTACCCTCAGCCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028492_4

>merge|NZ_CP028492|4|2054452-2054555|CRISPRCasFinder
GGCGGCTACGGCTACCCTCAGCCCGCCGCGCCCGCGGGAGCCCCGCCCATGCCGCCGTCGCCGCCCGGCGGACGCCCCGGCGGCTACGGCTACCCGCAGCCCGC

>NZ_CP028492|4|4|2054452-2054555|CRISPRCasFinder
GGCGGCTACGGCTACCCTCAGCCCGC	CGCGCCCGCGGGAGCCCCGCCCATGCCGCCGTCGCCGCCCGGCGGACGCCCC
GGCGGCTACGGCTACCCGCAGCCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028492.1\|WP_107904943.1\|2054887_2055403_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NZ_CP028492.1\|WP_107904940.1\|2051978_2052629_+\|FMN-dependent-NADH-azoreductase	unknown	unknown	gnl\|CDD\|224103
NZ_CP028492.1\|WP_107904938.1\|2049770_2051237_-\|DUF2252-domain-containing-protein	unknown	unknown	gnl\|CDD\|313268
NZ_CP028492.1\|WP_107905329.1\|2048338_2049310_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NZ_CP028492.1\|WP_107904939.1\|2051463_2051826_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP028492.1\|WP_107904947.1\|2062302_2063064_-\|class-E-sortase	unknown	unknown	gnl\|CDD\|320679
NZ_CP028492.1\|WP_107904936.1\|2046730_2047864_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP028492.1\|WP_107904948.1\|2063077_2064322_-\|class-E-sortase	unknown	unknown	gnl\|CDD\|320679
NZ_CP028492.1\|WP_107904945.1\|2058537_2060013_+\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_CP028492.1\|WP_107904944.1\|2057101_2058541_+\|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl\|CDD\|223843
NZ_CP028492.1\|WP_107904934.1\|2044497_2045724_-\|HTTM-domain-containing-protein	unknown	unknown	gnl\|CDD\|214802
NZ_CP028492.1\|WP_107904941.1\|2052904_2053267_+\|DUF1304-domain-containing-protein	unknown	unknown	gnl\|CDD\|377753
NZ_CP028492.1\|WP_107904946.1\|2060183_2062190_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP028492.1\|WP_107904933.1\|2043754_2044501_-\|TrmH-family-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|334162
NZ_CP028492.1\|WP_107904949.1\|2064318_2064957_-\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|181107
NZ_CP028492.1\|WP_107905330.1\|2055493_2057074_+\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_CP028492.1\|WP_030945481.1\|2064953_2065115_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028492.1\|WP_107904937.1\|2047951_2048281_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP028492.1\|WP_107904950.1\|2065169_2065880_-\|class-E-sortase	unknown	unknown	gnl\|CDD\|320679
NZ_CP028492.1\|WP_107904935.1\|2045720_2046527_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP028492.1\|WP_107904943.1\|2054887_2055403_+\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	5.50937e-20
NZ_CP028492.1\|WP_107904940.1\|2051978_2052629_+\|FMN-dependent-NADH-azoreductase	gnl\|CDD\|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	2.41488e-47
NZ_CP028492.1\|WP_107904938.1\|2049770_2051237_-\|DUF2252-domain-containing-protein	gnl\|CDD\|313268	pfam10009, DUF2252, Uncharacterized protein conserved in bacteria (DUF2252). This domain, found in various hypothetical bacterial proteins, has no known function.	1.57602e-163
NZ_CP028492.1\|WP_107905329.1\|2048338_2049310_-\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	0.00148419
NZ_CP028492.1\|WP_107904939.1\|2051463_2051826_-\|transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	4.72977e-32
NZ_CP028492.1\|WP_107904947.1\|2062302_2063064_-\|class-E-sortase	gnl\|CDD\|320679	cd05830, Sortase_E, Sortase domain found in the class E family of sortases. Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	3.22512e-37
NZ_CP028492.1\|WP_107904936.1\|2046730_2047864_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	6.7214e-43
NZ_CP028492.1\|WP_107904948.1\|2063077_2064322_-\|class-E-sortase	gnl\|CDD\|320679	cd05830, Sortase_E, Sortase domain found in the class E family of sortases. Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	1.14683e-49
NZ_CP028492.1\|WP_107904945.1\|2058537_2060013_+\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	1.23597e-87
NZ_CP028492.1\|WP_107904944.1\|2057101_2058541_+\|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl\|CDD\|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	2.02869e-79
NZ_CP028492.1\|WP_107904934.1\|2044497_2045724_-\|HTTM-domain-containing-protein	gnl\|CDD\|214802	smart00752, HTTM, Horizontally Transferred TransMembrane Domain. Sequence analysis of vitamin K dependent gamma-carboxylases (VKGC) revealed the presence of a novel domain, HTTM (Horizontally Transferred TransMembrane) in its N-terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is more likely caused by horizontal gene transfer than by early invention. The conservation of VKGC catalytic sites indicates an enzymatic function also for the other family members.	7.96377e-43
NZ_CP028492.1\|WP_107904941.1\|2052904_2053267_+\|DUF1304-domain-containing-protein	gnl\|CDD\|377753	pfam06993, DUF1304, Protein of unknown function (DUF1304). This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.	1.04958e-37
NZ_CP028492.1\|WP_107904946.1\|2060183_2062190_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.46212e-127
NZ_CP028492.1\|WP_107904933.1\|2043754_2044501_-\|TrmH-family-RNA-methyltransferase	gnl\|CDD\|334162	pfam00588, SpoU_methylase, SpoU rRNA Methylase family. This family of proteins probably use S-AdoMet.	1.96672e-33
NZ_CP028492.1\|WP_107904949.1\|2064318_2064957_-\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|181107	PRK07765, PRK07765, aminodeoxychorismate/anthranilate synthase component II.	1.41715e-143
NZ_CP028492.1\|WP_107904937.1\|2047951_2048281_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	1.02875e-24
NZ_CP028492.1\|WP_107904950.1\|2065169_2065880_-\|class-E-sortase	gnl\|CDD\|320679	cd05830, Sortase_E, Sortase domain found in the class E family of sortases. Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	1.14377e-56
NZ_CP028492.1\|WP_107905330.1\|2055493_2057074_+\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	1.1064e-81

>NZ_CP028492.1|WP_107904941.1|2052904_2053267_+|DUF1304-domain-containing-protein
MHAISVVLVALMALLHAYILVLEMFLWQRGPGRGLSGFDAELARATAPLAANQGLYNGFLAAGLVWGLIADDPTGRQVQIFFLSCMVVAGVYGAATANRRILFVQALPAAVTLATVVAAG
>NZ_CP028492.1|WP_107904940.1|2051978_2052629_+|FMN-dependent-NADH-azoreductase
MATLLHIDSSVFSTGASSSRAVTDAFRRIWQEQHPEGTVIHRDLAAQPVPHIDAHSHTAGFSDPATHTPEQAAAFAERVKLIEELESADAVLIGAPMYNLTIPSTLKAYLDNVVLMGRTAGDAQSIKGTPVTVVASRGGAYGPGTPREGYEYVQNYLSAILADFLGADLDFIVPELTMAPANPAMAELVPLFEASRERALDEATTKAKQLAQKLAA
>NZ_CP028492.1|WP_107904939.1|2051463_2051826_-|transcriptional-regulator
MAGEQSHDVAQCKRVDEGINRVFQLLGKRWTGPIVSVLTSGPAYFVALRRAIPGISERMLSDRLTELAAAGLVVREVYEGPPLRVVYRLTESGAALEPALAELGGWAKKYLGDGERPEGC
>NZ_CP028492.1|WP_107904938.1|2049770_2051237_-|DUF2252-domain-containing-protein
MTEVGAEAVAAEAAAAASESGEHTASAARRLPRVHGFAEWPGGGSPKEEGKELRKRVPRAEHAVFDLDASRPGAVAAVEESNLGRLTDLTPIRVGRMAATPFAFLRGSAGLMAYDLARTPMTRIRAQICGDAHAANFGLYADARGGLVIDLNDFDETLYGPWEWDLKRLATSLVLAGREAGADEDKCRKAAHDTVGSYRRTMRLLAKLPVLDAWNAIADEELVSHTDAHDLLGTLERVAEKARANTSGRFAAKSTAPTEDGGRSFVDAPPVLRRVPDEEAAAVAASLESYVTTLSEDRHPLLSRHAVHDVAFRVVGTGSVGTRSYVVLLLDHRGEPLVLQVKEARPSALVPHLVTAGFEAPGTDHEGRRVVLGQKRMQVVSDILLGWTTVDGLPFQVRQFRNRKGSVDPAALAADQIDDYARMTGALLARAHSHSADPRLIAGYCGKNEELDEAIAEFAVTYADRTEADHAELVTAVRDGRIAAEMGV
>NZ_CP028492.1|WP_107905329.1|2048338_2049310_-|hypothetical-protein
MTAAETADTAAESAGEAHQPADEAVEPAEGAVESAEEAAAVADEAVAAADEAVAAAEDAVAVEEPAERPEARLERAVRAAEQALIEYEIAVETFRVEVDNFSRLHHQKLGPMYTRLDELDARIAEAVAARTGDPEDIRKADEARARVMPMPGVEELFHGWMDGDGLFPEAAAMLTDQPVRPPQRVRPSDEARKLYRELARKAHPDLAQEEAERARREEFITRVNAAYARGDEALLRELAEEWAAGPAPKEQGPTPSEELYARLEWLAQRKEMLTLVAKDLEESAIGAMLRLAPDDPDRLLDEIAEQLLAQVAAREAELAALLG
>NZ_CP028492.1|WP_107904937.1|2047951_2048281_-|rhodanese-like-domain-containing-protein
MPTVEVTDLKDDDFLLDVREDDEWQAGHADGALHIPISEFVARYGELTEAAPQDGRVNVICRSGGRSAQVAMYLVQQGVDAVNVDGGMQVWAAAGRPVVNNEGQPGFVL
>NZ_CP028492.1|WP_107904936.1|2046730_2047864_+|acyl-CoA-dehydrogenase
MDFTFTEEQQAAAEAARGVFAGVAPDAVPSPALTPGAVADTFDRPLWDRLADADLLSLLLTEEYGGAGLDAVALCQVLRESAKALARVPLLESSAAMAAVQAYGGPELKADLLARAGRGELVLTVAAHGRTGHDPAELATTARRDGAGWVLDGVQTAVAWAYDADLVAVPARTDADLTVLALVPRDTEGVSLAQQFSTSGERLGELRLESVRLTARDVIDTEGAWEWLRELLATGTCALALGLGERVLGMTSEYASKREQFGHPIATFQAVAVQSADRYIDLRAMEATLWQAAWRITSGASGALPASGDVAVAKIWASEGVRRVVQTAQHLHGGFGADVDYPLHRYHAWAKHLELTLGPAAAHEEALGDLLAAHPLG
>NZ_CP028492.1|WP_107904935.1|2045720_2046527_-|hypothetical-protein
MDAYDAGSAARHGPDREPPLVPPPAPPAEPSLALPPPPPPEPEARTGVAALSLRYQIVAALAVAVVAIVVCVHTGMVFLHVAPPNTVTKKHSRAIDDWIYPEFEQNWKLFAPNPLQQNIAVQVRAQVGTGGDGTRTTGWYDLSAQDGEAIDGNLLPSHTQQNELRRAWDFFVATHDTENRPVGLRGALSETYLRRIVELRLDRADAAGEGGVVERVQVRSRTTNVPPPKWSEEQISDKPSYRVLPWWSVPEDRAAAADAAGIGAGGTR
>NZ_CP028492.1|WP_107904934.1|2044497_2045724_-|HTTM-domain-containing-protein
MNRFALAVSSAIARVTESALGPYQTAVIRIGFSATWVLFLLREFPHRQELYGPGGPWDFDLAQQLIGTNGSFTALMWFRGGIWFETVYLFAVLTAVLLLVGWRTRAMSVLFMVGVLSLQNRSIFMGDGGDNVLHLMCVYLVFTRCGQVWSLDERRARRAREAHARGERVAPDRVGPALWSVSGFVLVAMTAAGRLDGDLTVPLILWISWLAPAVWWIVGRRARTAEPRILLDVIGNVVHNGALLVIMAEACLIYATAGWYKIQGSRWQDGTAVYYPLHLDYFSPWPALADVLSSSGTMVMLITYGTVVVQVAFPFTLFNRRVKNVLLAAMITEHAVIAVVLGLPFFSLAMIAADAVFLPASFLRRLGDLAARARGRLAGLVRRGDHPVKPPAPRSPENPEHAHVGSSA
>NZ_CP028492.1|WP_107904933.1|2043754_2044501_-|TrmH-family-RNA-methyltransferase
MTLASWNRLAETSVLLDGFHALKHAVRFSAEVPVAVAVDREAALALADELAPDVRDALDGLLTEVPELTYKSLVPRPHPTAVAALALRPSRAAGLGKLAHTPRTAPVVVLDNPRNLGNAGAVIRLAAGFGVTGVVTTGTLDPWHPTVVRGGAGLHFATVVERLTVPELPPGPLFALDPEGDDIRGVKLPDDAVLAFGSERSGLSAELRARTDHLLSLPMRPQVSSYNLATSVAMTLYHWSLTGGAARA
>NZ_CP028492.1|WP_107904943.1|2054887_2055403_+|FHA-domain-containing-protein
MSELTLTVMRLGFLAVLWLFVIVAVQVIRSDLFGTRVTQRGSRREAGRQQQAARQAAAPPQQRGQQAGGRQRRNAPSKLVVSEGTLTGTTVALQGQTITLGRAHDSTIVLDDDYASSRHARIYPDRDGQWIVEDLGSTNGTYLDRSRLTTPTPIPLGAPIRIGKTVIELRK
>NZ_CP028492.1|WP_107905330.1|2055493_2057074_+|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase
MYPEPTGEVRMSLSLRFAAGSHKGMIREGNEDSGYAGPRLLAIADGMGGAAAGEVASSEAISTIVALDDDVPGSDILTSLGTAVQRANDQLRSMVEEDPQLEGMGTTLTALLWTGQRLGLVHVGDSRAYLLRDGVLTQITQDHTWVQRLVDEGRITEEEATTHPQRSLLMRALGSGDHVEPDLSIREVRAGDRYLICSDGLSGVVSHQTLEDTLASYQGPQETVQELIQLALRGGGPDNITVIIADVLDLDTGDTLAGQLSDTPVVVGAVAENQPHHLHDNGIMQTPAGRASGLGRQVPGQGGGGGEFGPPGSGDTTGYAPAGGFGDYTDDDFVKPRKGRKWLKRSFYSVLALAVIGGGMYGGWRWTQTQYYVGTNEEHVALYRGISQDLAWVSLSKVEKDHPEIELKYLPPYQQKLVEATIAEGGLKDAQAKIDELQLQATACKKRAEQQAAQSEQNAKTGEGEAGGTTGTTRTSLTSKATPTPNPSASTKSPPPSTSPTPTATPSPGPTLSEEEQKVVSNCGTQ
>NZ_CP028492.1|WP_107904944.1|2057101_2058541_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MSSTTNSPTHHTSTIGAIGAPSRRNTELVLLAFAVVIPVFAYANVGLAMNDEVPAGLLGYGLGLGLLAGIGHLAVRKFAPYADPLMLPLATLLNGLGLVVIWRLDQSKRLSNYADAAPRQLLYSALGVALLVAVLVFLKDHRVLQRYTYISMAGALFLLILPLVPGLGANIYGAKIWINIPGLGTVQPGEFAKIVLAVFFAGYLMVKRDALALASRRFMGLYLPRGRDLGPILVVWVISILILVFETDLGTSLLFFGMFVIMLYVATERTSWIVFGLLMSAVGAVGVASFEPHIQTRVQAWLDPAREFQLSRAGVQDGILHSEQAMQALWAFGSGGTLGTGLGQGNSDLIGFAANSDFILATFGEELGLAGVMAILLLYGLIVERGVRTALAARDPFGKLLAVGLSGAFALQVFVVAGGVMGLIPLTGMTLPFVAYGGSSVIANWALIGILLRISDTARRPAPAPAPNPDAEMTQVVRP
>NZ_CP028492.1|WP_107904945.1|2058537_2060013_+|penicillin-binding-protein-2
MNKPLRRIAIFCGLLVLALLIRDNWIQYVQADELRTDKANRRVTIERYGTPRGNIIVDGKAITGSKETSGTDFKFKRTYTNGPMWAPVTGYASQAFGANQLESIEDGILTGNDDRLFFRNTLDMLTGKEREGGNVVTTLNAAAQKAAYEGLKDRGKGAVVALEPSTGKILALASFPSYDPSSFAGNSTTTDSKAWTKLQKKNNPDDPMLNRALREVYPPGSTFKVVTAAAALEHGLYTDADAKTDSPDPWVMEGTTTKLPNEGTIPCKNATLRVALKFSCNTVFGKVGSDLGNDKMLETAKKFGFTEEQFTPTRTSASVFSDDMNPSQTALSSIGQFNTAATPLQMAMVASAVANNGTLMKPYMIDELQTNNLDAIEKTDPEEMSKPLSAENAQKLQSMMETVVEDGTGKNARISGVKVGGKTGTAQHGVDNSENPYAWFISYAKLDDGSAPVAVAVVVEDQNAVRDDISGGGLAAPIAKSVMEAVIKSKK
>NZ_CP028492.1|WP_107904946.1|2060183_2062190_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MEEPRRLGGRYELGQVLGRGGMAEVYLAHDTRLGRTVAVKTLRADLARDPSFQARFRREAQSAASLNHPAIVAVYDTGEDYIDNVSIPYIVMEYVDGSTLRELLHSGRKLLPERSLEMTIGILQALEYSHRSGIVHRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMTMTQTSAVIGTAQYLSPEQAKGEQVDARSDLYSTGCLLYELLTVRPPFVGDSPVAVAYQHVREEAQAPSVFDPEITPEMDAIVLKALTKDPNYRYQSADEMRADIEACLDGQPVAATAAMGSVGYGGYPDDQPTTALRSADAGATSMLPPMNPDDGGYGYDDRPDRRRQKKSNTSTILLAVAAVLVLVGAILIGKWVFDGDTASNSQVAVPNVVGETESSARDLLGNVDLTIGKVTPKACEDQSKGKICSQTPGSKTKVDKNTTVDIVVSTGAPKVSVPDVEGLPYEKAKSDLEDKGFDVQQKTEESDRNPGVVISQDPEGGTEQEKGSTITLTVAKEKEQSTVPDVLGKTCDEAKAQMEANDLSGNCQEVDTQDPNQVGKVISTSPTAGTQADKGDTVTIQIGKQAEQQQATVPTVTQLSLKDAKKALEQAGLSVGQISGSQDDNAVVISQDPQPNTQVAQGTAVNLVAFGQGGNNNGGGDNGGQIFGGVNGVSARTDD
>NZ_CP028492.1|WP_107904947.1|2062302_2063064_-|class-E-sortase
MAATTEGTEDHTAAPASRRPPVRRRRMGRIAMAVSVFGELLITAGLVLGLFVVYSLWWTNVIADRAADKQADKVRDIWAHQDDDSGRPAEFDAKNGIGFLHVPAMTKGEILVEKGTTSKILNDGVAGYYTDPVKATLPTSDKKGNFSLAAHRDGHGAKFHNIHKLEKGDPIVFETKDKWYVYKVYAVLPETSKYNVQVLGGIPKESGKTKAGHYITLTTCTPVYTSRYRYVVWGELERVDKVDEDRTLPEELQ
>NZ_CP028492.1|WP_107904948.1|2063077_2064322_-|class-E-sortase
MTALRPERESGAAYGESFTDSYGDTGDQGSSYGQQPYEGSGALGEWYGEESYVTQAQQAAEARAAAGYGADGYGAGGYGSEGYAGQSYQAPVAQEPHAEPYMPPPDDETVALRVPDPPPSREPISPSPASSAASASSTPTGGRAARRKAAKGRHGRHGGTHQASDAAETDSESSGAPLSRMEARRQARARKPGPATVASRAIGEVFITTGVLMLLFVSYQLWWTNVRAHAQADKEASSLQEDWASGKRNPGSFEPGQGFALLHIPKLDVVVPIAEGISNKKVLDRGMVGHYGEGKLKTAMPDAKTGNFGLAGHRNTHGEPFRYINRLAQGDEIVVETQDKYFVYKMASILPVTSPSNVSVLEPVPPGSGFTGPGRYITLTTCTPEFTSKYRLIVWGKMVEERPRSKGKPDALVS
>NZ_CP028492.1|WP_107904949.1|2064318_2064957_-|aminodeoxychorismate/anthranilate-synthase-component-II
MSARILVVDNYDSFVFNLVQYLYQLGAECEVLRNDEVSTTHAQDGFDGVLLSPGPGTPEEAGVCVEMVRHCASTGVPVFGVCLGMQSMQVAYGGVVDRAPELLHGKTSLVEHEGKGVFAGLPSPFTATRYHSLAAEPATVPADLEVTARTHDGIIMGLRHRELPVEGVQFHPESVLTEHGHRMLANWLVECGYEDAVARSAGLAPVVGRATA
>NZ_CP028492.1|WP_030945481.1|2064953_2065115_-|hypothetical-protein
MYGWIWRHLPGNAWVKALLSLALAMAVVYVLFNYVFPWAEPLLPFNDVTVDNQ
>NZ_CP028492.1|WP_107904950.1|2065169_2065880_-|class-E-sortase
MRVVVRTVSELCITAGTVIVLFVVYVLFWTGVKADNVMDDQIDQLQEQWAQSAVRPPDTAPGGAAASPGATASPPKPAPYTSDKPFAIMYIPRLGFTWNKPVLEGTATKTLKKGLGHYANTAQLGQKGNFSVAGHRRTYGDPFKDFPRLRPGDAVVLTDGTTWFTYRIDKGPYKTLPADVEVIDPVPRKSGYTREGRYLTLTTCDPEWGHSHRLIVWAHLDSTQPVEAGKPEALRR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP028492_1	1.1\|959020\|28\|NZ_CP028492\|CRISPRCasFinder	959020-959047	28	NZ_AP017899	Sphingopyxis sp. FD7 plasmid pSFD01, complete sequence	189625-189652	5	0.821

1. spacer 1.1|959020|28|NZ_CP028492|CRISPRCasFinder matches to NZ_AP017899 (Sphingopyxis sp. FD7 plasmid pSFD01, complete sequence) position: , mismatch: 5, identity: 0.821

gacccgcggacacaagacgaccacggca	CRISPR spacer
gcgcggcggagacaacacgaccacggca	Protospacer
*  * ***** **** ************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

5. NZ_CP028508

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP028508_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028508_1

556702-556785

Orphan

Consensus_repeat	Method
GTGCTACCTGAGAGTGACGGCGTAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028508_1

>merge|NZ_CP028508|1|556702-556785|CRISPRCasFinder
GTGCTACCTGAGAGTGACGGCGTAGCCCTTCAGGTCATCGAAGCGCCGTCCCGTGCGGCGTGCTACTTGAGAGTGACGGCGTAG

>NZ_CP028508|1|1|556702-556785|CRISPRCasFinder
GTGCTACCTGAGAGTGACGGCGTAG	CCCTTCAGGTCATCGAAGCGCCGTCCCGTGCGGC
GTGCTACTTGAGAGTGACGGCGTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028508.1\|WP_107910879.1\|566715_567270_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227100
NZ_CP028508.1\|WP_107910887.1\|569037_571206_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP028508.1\|WP_107910861.1\|545862_547314_-\|DUF1996-domain-containing-protein	unknown	unknown	gnl\|CDD\|370451
NZ_CP028508.1\|WP_107910885.1\|568610_569012_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028508.1\|WP_107910875.1\|564588_564969_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028508.1\|WP_107910866.1\|552133_552778_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378566
NZ_CP028508.1\|WP_107911214.1\|550949_552056_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028508.1\|WP_107910871.1\|555897_556431_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319910
NZ_CP028508.1\|WP_107910868.1\|553083_555420_-\|MEKHLA-domain-containing-protein	unknown	unknown	gnl\|CDD\|369272
NZ_CP028508.1\|WP_107911217.1\|560480_563744_+\|hydrolase	unknown	unknown	gnl\|CDD\|379971
NZ_CP028508.1\|WP_107910877.1\|565882_566524_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028508.1\|WP_107910882.1\|567397_568555_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224662
NZ_CP028508.1\|WP_107910851.1\|542404_543580_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028508.1\|WP_107910856.1\|544264_544729_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP028508.1\|WP_107910864.1\|549618_550794_-\|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase	unknown	unknown	gnl\|CDD\|234825
NZ_CP028508.1\|WP_107911219.1\|573519_574101_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028508.1\|WP_107910889.1\|571216_573520_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP028508.1\|WP_107910873.1\|564004_564592_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NZ_CP028508.1\|WP_107910854.1\|543576_544053_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380190
NZ_CP028508.1\|WP_107910859.1\|545040_545775_+\|translation-initiation-factor-IF-2	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP028508.1\|WP_107910887.1\|569037_571206_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.76538e-83
NZ_CP028508.1\|WP_107910861.1\|545862_547314_-\|DUF1996-domain-containing-protein	gnl\|CDD\|370451	pfam09362, DUF1996, Domain of unknown function (DUF1996). This family of proteins are functionally uncharacterized.	7.24712e-31
NZ_CP028508.1\|WP_107910868.1\|553083_555420_-\|MEKHLA-domain-containing-protein	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.85522e-41
NZ_CP028508.1\|WP_107910879.1\|566715_567270_-\|hypothetical-protein	gnl\|CDD\|227100	COG4758, COG4758, Predicted membrane protein [Function unknown].	0.00599005
NZ_CP028508.1\|WP_107910866.1\|552133_552778_-\|hypothetical-protein	gnl\|CDD\|378566	pfam11139, SfLAP, Sap, sulfolipid-1-addressing protein. SAP is a transmembrane transport protein with six predicted transmembrane helices, with a hydrophilic domain between helices 3 and 4. This hyrodphobic region is highly variable among identified Gap-like (GPL, peptidoglycolipid, addressing protein) proteins and may be involved in substrate recognition. SAP also belongs to the LysE protein superfamily (pfam01810), whose members have been implicated in small molecule transport in bacteria. Other Gap proteins export metabolites across the cell membrane so it is possible that Sap specifically may be involved in transport of sulfolipid-1 across the membrane.	7.31624e-27
NZ_CP028508.1\|WP_107911217.1\|560480_563744_+\|hydrolase	gnl\|CDD\|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	1.54729e-114
NZ_CP028508.1\|WP_107910882.1\|567397_568555_-\|hypothetical-protein	gnl\|CDD\|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	3.389e-18
NZ_CP028508.1\|WP_107910871.1\|555897_556431_-\|VOC-family-protein	gnl\|CDD\|319910	cd07246, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	4.61403e-41
NZ_CP028508.1\|WP_107910856.1\|544264_544729_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00153349
NZ_CP028508.1\|WP_107910889.1\|571216_573520_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.52872e-77
NZ_CP028508.1\|WP_107910873.1\|564004_564592_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	2.58129e-24
NZ_CP028508.1\|WP_107910854.1\|543576_544053_-\|hypothetical-protein	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	3.17359e-05
NZ_CP028508.1\|WP_107910864.1\|549618_550794_-\|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase	gnl\|CDD\|234825	PRK00726, murG, undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional.	1.01289e-120

>NZ_CP028508.1|WP_107910871.1|555897_556431_-|VOC-family-protein
MSEQAGAAPEGYTTVAPWIVTDDTGAFLDFATQAFGGEELARVSTEDGLIGHGEIRVGDTVVLAFDRHTDWPAMPSLLRVFVADADKVFSQAVEAGGQVVTALTDDAFGQRGGRIKDPFGNIWWVVSCVEDVSEAEMWKRLQDPVYAESMRVAQETLDAELSGHPHGRSSAPVRGSS
>NZ_CP028508.1|WP_107910868.1|553083_555420_-|MEKHLA-domain-containing-protein
MSNVITSASSDGAGTTERSDGRGDAATPAIAAIAAGQPRTAEDRFRSLLEAAPDAMVIVDDTGMIKLVNAQTEVLFGYRRDELLEHPVEMLIPGRFRAQHAAHRDGYAATRQVRPMGAGHELHGLRRDGSEFPVEISLSPLETPDGLLVSAAVRDVSERKAAEERFRGLLESAPDAMVIVDDTGIIKLVNAQTEVLFGYRRDELLEHPVELLIPYRFHAHHTQHREGYAATRQVRPMGAGLELHGLRKDGSEFPVEISLSPLETADGLLVSAAVRDVSERKAAEARINELAALVESSQDAILAKTLDGRITYWNVAAQQLYGYSAEEAIGRHVSMLAPPERKDEITLLLERLRKGEKIEHFETLRLTSTGAALDVDVTLWPTYSPDRTVIGACAIIRDISDRKRAEAELTALYEQQKHIALTLQRSLMGTPPAIPGLEAASRYRPATQGPGVGGDWFDLIPLGAGRVGILIGDVMGRGLEAASVMGQLRSAAHALAKTGMQPRQLMQALDAVVADLDVPDQLVTCCYLVIAPDSGSVTVCSAGHLPALVATPGGRVHRLVSPVNAPLGVGDILYQQTDAAIPPGATLVLYTDGLVETPGSDIEDEIDKLSTTLAGAFTRTRRLEATADHVLAALLPDPEGHDDDVTLLLAQLPAAPLAAASVELPAAASSVPAGRSFVVENLTAWDCASAADDARLLVSEILTNAVQHAEGPLVLHLRRTTTELAIEISDLSPHLPQPRLAAQDDESGRGLILVDAVADSWGVRPDERGKTTWFTLRL
>NZ_CP028508.1|WP_107910866.1|552133_552778_-|hypothetical-protein
MVLDLVVIGTAITLGPLHNSAFILLLSSRRGVRLGLAFLLSWLANLIVVIACVLLLTGGEPPARHSAPSTAATAAKLAIGLALVLYSAYRYRRPPRPHSPPRWTARIDDISTVTAGGLAWVFQPWALVGAGAATAVDADLSTLADWLALTGYCLLATLSLIAMELYVVWAPAVANARLNALRTWLEQHQEQLIVTLSLLFGLWLAARSIAELVA
>NZ_CP028508.1|WP_107911214.1|550949_552056_+|hypothetical-protein
MFVFACAECDAALTVPLSQVALPAHARQKYGNGAQLPVLMKSGTFAVDPDPWGGPWRMWDELEPGEAEARGIYAPVHALSDSAPGAFAIAPGDVRGTRMIPEMRGGACCGLDGADGPNMACETCDLPVATRIDDCSLWQAVRLSPDAVRRVRVESVHPAPLSWTELTEQEESTPPFEPISTWGGRLGTSHYWSWSPQWGAAAGHALAHLLAASEGQPVTVPTGLTADVFQRALDALLPVGPPKRRAVLAGPGRPTPDTGVDILLVPVHPQTGRTWAPDGPATSAYRVPLPLGVWLWLVSAQPYLPVPATGRLPDEVLREEPLPPRPNYLFRADWGTFQHTLVRLRAVRSPWLRKILESRPQDGTADFF
>NZ_CP028508.1|WP_107910864.1|549618_550794_-|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase
MKNEPSNPDVFRLIVTGGGTGGHTYPALTAIRTLQNRLAAEGKALDVLWIGTAEGLEARIAPAEGIAFATVATGKIRRSSNPLKMMSAANVRDMARVPLGVAQARKIISSFEPDVVLATGGYVAVPAGLAARMCRRPLVLHEQTVRLGLANRKLAGSATRIAVSSESTLPLLPQEVRGAAVVTGNPIRPEVLTGQADKAVQALGLHGFDRRLPTVYVTGGAQGSQQINGVVRDALPWLLERANVIHQCGPDNAGELRQYAATLPAGSAGRYHLAGFVGPELPDVLALADVVVSRSGAGTLAELTALGKPAVFIPLASSAGNEQAHNARHLEESGAAIALLGDVTADQLRDAVGPLLADPAGREEMARRARAHGRPDAADRLVDVILSAASG
>NZ_CP028508.1|WP_107910861.1|545862_547314_-|DUF1996-domain-containing-protein
MRHNTRKRSKTTQRAIAATAGLALGAGALIAVNVYASAHESTNGNSTKRAAQGLADPAGGATTISCPDVGAKLTSVPERARTQVDRELALLDKQVAEAYQKLRSSAKAIQQDRSFATNAIMAPLKDRRTATIDRIAIAIGRSGTGPQGLEALAACTLRATDAQQEQGPGQEQGDTAVQGNGPVAADFVDITTVRPNVKSPRKQRGASAGRFTTQCGVNENKLYNSDNIIVAPGVDNGAHHTHDYVGNQDNDAFTTNQEFAAAATSCRNQGDKSTYYWPVLRLQDGKQEFDAQELGGGAEGNTGTILTASKVTLNFVGSPRGRVVAMPKFLRIITGDAKAFTNGTANANASWSCTGFENRQLTDKYPICPQGSSLVRTSKFQSCWDGRSTDSANHRSHVAFADPRTGACPSGMKAIPQLVQRLVYDVDAPSLDDNGQSTPFYAVDGFPEQMHKPITDHGDFINVFDERLMNRMVQCINTGRACR
>NZ_CP028508.1|WP_107910859.1|545040_545775_+|translation-initiation-factor-IF-2
MRRLLLLAPLLLFTVGCGVVPSSEDEATDAAREAARHAGEVLYGQRPRTAEEVGRSASGIDGVEVMRVTGTSTHDGDGIDVIVRTSGSAYNEWRDPQEVTVRRCFAVRVSPKSEWREEPRDADCPQGPPLTFAPPPEPPQLPYEELRAKLPRVPEGGRVDEAEVRRTLAALDLDPAIRTEVKADGGRVGVLLSVKGNGFDPQDCLLARVGPGATEVWVPSRIQRMPGEGGCSIANALDPMPAPH
>NZ_CP028508.1|WP_107910856.1|544264_544729_+|hypothetical-protein
MFAAEGSGNAMSMSPSNNDTSQDSVSAKAAASKARRTTSRATAPASKAADKAADKAGDAASAAAGAAERTAKATTSVAHAAAQRVEAGRMAVVSASGQAAAFAKSTWTLIANRKILAAGVGAGLTALSAMSYAVGRRSGRRTLGPITRMTGGRI
>NZ_CP028508.1|WP_107910854.1|543576_544053_-|hypothetical-protein
MSEPVDPRLAYATAAEPSPGPTPGPTPAPPPSDPGSDGDGGPSPEPSPSPNPSPTPPAPWGTDPDVGVTSSFLRRRADDCETASEIIRKTRGVAEDANNDLARAADGWQFTSSLDELQGRWEALNNVVVQRLDQAAANFRLSADAYDANETRTASQFS
>NZ_CP028508.1|WP_107910851.1|542404_543580_-|hypothetical-protein
MSLRTTDRTGTRGQDMPGFYALLQLDVAGLETFADEWVTVHRKLTEARTGFHDDVVKPLHEDHWRGEGGRAAQDYCDRVQMDIDALDKEVRALRNFLDTEADGATGRGGVKGLAGLKLRAENLQREALTEGMNITDSGTVEWEVMYDPNDPETPKMLDERRNTADSLQTRVRTLLDDAAEDDEWLAKSLKVIFGTVGNFESENRRFGIVEPTAKDRQVYNQLNNVAAYFAVMKGWPTAAGLVQHYLDGSGKPVEVEPQQMMNDIPAFRKDVDGTLENDVRKRGDGPFTTEWSSTAPNPADGDRSMEWYYALNHFQYRLVGEKQGDEIKYHVEVQKRYDWGIPSEHRATVSGGGPGPMGMDLEQADIAHLHTSGMAQDFDVSGSSDEMTARS
>NZ_CP028508.1|WP_107911217.1|560480_563744_+|hydrolase
MPGKWDRRTFLRATAGTVGTGIPALSAATPASAVPALGPQASKADGTRGLRITRTTVEHAENVLGTDVAHPRLAWELASSGHGARQTAYRVQVRAGGAGWAGSLVWDSGKVTSANSVGVAYGGPALKPRTRYTWRVKVWDGQGKASAWSAPRWWETTLSPEEWGASWIGVDNPEPLDFTGASWIWATGASVENAPVGTRWFRSHLNLPGDGEVLKATVVATADDDFTLYLNGREAVRAPQQQDGWRSGRTADVTGEVKEAAGVVLAVSATNRAGASVNPAGLLVRLRVETSTGRTYELLSDAGWRVTDAEQQGWQEPEFDDSAWHPAVVLAPYGQGPWGTGVSVAVSEQPSPLLRREFEVPGRVSRARLYISGLAYYEARINGRRVGRQVLDPGFTDYDETVLYTVHDVTELLRRGANAIGVSLGRGFFGMTTPNVWNWHRPPWHSEPRLIARLEIEHPDGSRTALVTDDEWRITEGPILSNSLYAGETYDARREPGPWTSPGFDDSTWRTATVQSAPKGSLRAQPHDGIEVIDSFNPERTTRLAPGVHLVDMGRTMAGWARITVRNLPAGTSLQLTYGEKLKPDGSVSAETSHVPGRFQRDEYICAGREEESWEPAFSYKGFRYVQVSGLPETSDDAWRILGRLVHTPLDEVSSFTCSEPFYEWLDRAMRRTVLNNMHGIPTDTPMYEKNGWTGDAQLGTPVMTYAFAMHRMLSKWQGDLADSQTDDGQLPVIVPSGGWGYGDLGPSPEWTTVYPFLIREFYRVYGDEHAAREHWTTLTRYLDWELSRLRDGLAVTALGDYLAPGYGGNPPEDTRLTATAYLYRALLDTAEMGEVLGADDVVTRYQKAAEQLKTALNAAFLGADGHYRTAKDPDYRQTSNAIPLAFGLVPDDARDSVFASLVRDVERRGNHLNTGALGTSVLLRVLCAHGRPDLAHAVATQRTYPGWGYWHDNGADTMWEMWPLDSRSRDHYFQGTAAQWLYENVAGLRPGDAGYATFTVRPDARTGVDWARTSIRTVRGTAGVAWSQTAGGFSMEVRVPVGAIAEVHVPVEGRDKVTAPDGARHLRTDSGFAIYRVPHGTWRFTS
>NZ_CP028508.1|WP_107910873.1|564004_564592_+|TetR-family-transcriptional-regulator
MSSVPSPKGRPRDPRSHEAIVNAAIELLIEVGYAATSIGAVAARAGVGKDTVYRRWRGKPELVFEAVFTTTDQAPIPDTGTLAEDLTALLQGLVDEFHAPAAAAALPGLLADFTADPVLKSRIRSDFLAPSKERLLVVFQRAVARGEIAADTPVDLVLDTLAGAVFFHVGLVGQDPDRELAGRLAAVIAKGIEIR
>NZ_CP028508.1|WP_107910875.1|564588_564969_+|hypothetical-protein
MNGWFLAAGITSFGVAAVHLVAGHRDVVRPLLACALADDPKRVLHAVWHMVSVDLTLSAAVLVFLALADDTSTTGLVAWFVAAHFVAYAVAFLVVTLSVGWPKPLLRLPQWILLLPVAVLTVAGIG
>NZ_CP028508.1|WP_107910877.1|565882_566524_+|hypothetical-protein
MLGWIIFFAVILAPSLVGLTFAVRTARRVGKADRAMRALAARPDWEQLKRDKDGAQWSGYAIHFPWLLRAQHGTTVTGPLGEHRVTVARLVENLTSRVDAHWLVVVFDVQGSRANLRLERNWSAAELGLSFHKDAPYLPMSDDHAGTTERFHASELPARLVELAGPAVSVTKDGVCFVHHPLPDVVDMDRLLEELAGMLPDLLALAGDSAPER
>NZ_CP028508.1|WP_107910879.1|566715_567270_-|hypothetical-protein
MNPGQQMEFHASCGHLISAPADRAGQDARCPHCHQVVRVPQSDVPYASPVPVPAGATEPIALTALYVTALIGGLMGAGLIYMVMFNEFSESELVTITPLWFFPIVFGLYGFVSQRLLRRIASGRAGTLSEAARITIDVAGHWAALVLFPFLVLKWRSSLLVSLAAALFWAVLLWLFFTAVFPSL
>NZ_CP028508.1|WP_107910882.1|567397_568555_-|hypothetical-protein
MRRPLTCHRMGESNIVVVGGSGFYGRYVVADLLRRSDVRVTVVSRSAPRPAFSSDRVHWAAGDRDAPERLAELLGDAAAVVHCAGPFQALDGPGSHPLGPLRAAVSAGVPYVDIGEDRAFVRAASTLARSATAPVLTGASVVPGLQALIVHDLAHGMDRVDTVLCCAAPDTRRHRGPAMFEAMMHGAGLPFTAPRGGVPTVVHGWSEPEWTLFPPPVGRRLVHQVYEMADLDVLADLCGAGTIAFKAGTEFSAVNRALGLFAALRARTGRPRTTRHWTPLVRAVSWLVGRVGDEAGGFTVTVSGERGGRPITRRLGMTARQEGGRIPSLLAGIAVDHLLSGRLHTAGLVPLHSWLAPHELRTALRERGISLWRRDDEDEWRPWQE
>NZ_CP028508.1|WP_107910885.1|568610_569012_+|hypothetical-protein
MHRRIFVAAGVYNVVWGCYAAVDPQWLFRVAGMPPQNHPQIFMTLGMVLGLYGLLYLDVALRPAEGFPIAAVGLAGKVLGPLGWLWLAVTGEWPLASGVILVTNDLIWWVPFALYLHDCLPQWRARYLGERRG
>NZ_CP028508.1|WP_107910887.1|569037_571206_-|serine/threonine-protein-kinase
MEPLRGADPARIAGYRLFRRLGAGGMGVVYLARSGGGSLAAVKVIRAAYADDPGFRARFRREVETAGRVANPWVVPLLDADPDAESPWLATEFVPGPSLAEAVEECGPLPYRSTRVLGARLAEALEAVHGAGLVHRDVKPANVLLAVDGPRMIDFGIARPPEDTALTASGMVVGSPGFLSPEQAQGRGREIGPASDVFSLGCLLAYAVTGERPFGWGSAAEALVRTVHDEADLDAVPAPLLPLLRNCLAKEPGARPTVPEVRAALDRAGEAGGWLPESLTRLIARRSAAVLALPAVEATEVSGAPAGADTMPGGQERSKGTTRRRLLMLGSSAGVVAAGATAAWWTAGRPRRGPAQGGGTRLPEQVVALHADLTGDQKTAGLAQQNGVRLAVDHFNSRADRAFDLALQVHDDAGSTTRAQQIARQLSADDRVRAVIGPTTDACAKAVLEQYREALLPMVCVSVGLDGVSAARYRTYAATRPPDRSLAAPLVAHLVRTVRTRRTMLIDDAAQGDFSWELCADVAQALRSGQRTTTRRTLAAEDDTADDFRALAETVTDWKADAVLFAGGFERAAKLARALRAAGYSGARLATQHALDTRFFTVAGEAAEGWVFATTFLDPTRVTAAKSFVADYRHRFGTAPPWYSAEAYDATLFVARALTTLRASLTERGPLVGRLRETDYRGITKRLRYTASSTGYTTKAMYLFQASGGRFRFLGQFEDATT
>NZ_CP028508.1|WP_107910889.1|571216_573520_-|serine/threonine-protein-kinase
MEPLRNSDPSRLAGHRLLGRLGAGGMGVVYLARSAGGSLVALKVIQAEYAEDAGFRERFRREAETARRMTSPWVASLIDADPDAAQPWLATAFVPGPSLGEAVAAHGPLPVRGLRVLGTRLAQALGNLHGVGLVHRDVKPGNVLLALDGPRLIDFGVARDPQDTSLTSTGVVVGTPGFLPPEQAEGTGELGTPGDIFSLGCVLAFAATGRPPFGTGSLDALLYRTVHDAPDLEGVPRPLAEVVRSCLEKDPQLRPTAEALSETLTVTASETPPDPREALRAVRLAPPQDTDTPDAVADGEAGQAADGQFPADEAWLPEPLVLLIAERSAAGLALPAVDETEVDPASAGTAPPDTTASQPPARAVARRRFLLLAAGAAVVAAGGGLAAWAGLDGDDGGEDDATPTATGPVYTLGLHADLTGDQKADGRAQERGLRLAVHEFNSRAGKPFTLAVKTVDDGGDPTRAPKAAKELVADRSVLAVIGPTTDDTALASLATYDAASLPLIAVTPGATVLQVMGSRSFLHARVTDTLLPLYLDAYLRGTAKSRTVGIVDDRAADAYAWEISSTLADVLRKVPLPAVPKVVSALRTDFGPTLDALLDGGADSVVFAGFHDRAALLARELHRRDFPGARAAAQGVLDARFLSAAGDAADGWVIVAPAMDATVALEAKAFRAAHRGLFGAEPERYAVETYDVAQFAVKTLRSLSVGRRTRQTLATALRSGSYKGIARNLAFSKETGALVADGSGVHLWKVERGRFAYQGPAPYQVAG
>NZ_CP028508.1|WP_107911219.1|573519_574101_-|hypothetical-protein
MVESVVFAPGDWGRGFVAQDPAESRPGTWAVLDDGCRWEREKTPRGVLASLSRYSLLPAAGSKGAVKVTAVATAHYSALGADEQLSTTLEEVLRCPEQHPRADSRITGLNSLGTPFGAREQEYADDSVLEAGQYVDKGDAAQPYRWMVARLGTVVVAVSVTGAKGHTEQELQQLGADALGQMLVRVQQRLKVK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

681221 : 693549

Bacillus_phage(50.0%)

plate,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_107911027.1\|681221_683393_-\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_107911029.1\|683389_685642_-	hypothetical protein	NA	NA	NA	NA
WP_107911031.1\|685598_686075_-\|plate	phage baseplate protein	NA	NA	NA	NA
WP_107911248.1\|686071_686791_-	type IV secretion protein Rhs	NA	NA	NA	NA
WP_107911033.1\|686807_688031_-	type IV secretion protein Rhs	NA	NA	NA	NA
WP_107911036.1\|688017_688749_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_107911038.1\|688748_688976_-	hypothetical protein	NA	NA	NA	NA
WP_107911040.1\|689046_689556_-\|tail	phage tail protein	NA	NA	NA	NA
WP_107911042.1\|689552_691013_-\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	3.8e-14	25.7
WP_107911044.1\|691202_691658_-\|tail	phage tail protein	NA	NA	NA	NA
WP_107911047.1\|691695_693549_-\|tail	phage tail sheath family protein	A0A1J0GW47	Streptomyces_phage	8.7e-32	25.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

6. NZ_CP028494

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP028494_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028494_1

989960-990051

Orphan

Consensus_repeat	Method
CCCAGGGGCGCGGGGAACCGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028494_1

>merge|NZ_CP028494|1|989960-990051|CRISPRCasFinder
CCCAGGGGCGCGGGGAACCGCGCACGGCCGCCATCGCAGCGCCAACCAAACAACCGACGGCCCCGCAACCCCAGGGGCGCGGGGAACTGCGC

>NZ_CP028494|1|1|989960-990051|CRISPRCasFinder
CCCAGGGGCGCGGGGAACCGCGC	ACGGCCGCCATCGCAGCGCCAACCAAACAACCGACGGCCCCGCAAC
CCCAGGGGCGCGGGGAACTGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028494.1\|WP_107906061.1\|990098_990749_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226789
NZ_CP028494.1\|WP_107906064.1\|993210_994113_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP028494.1\|WP_107906056.1\|980811_982032_-\|TIGR00645-family-protein	unknown	unknown	gnl\|CDD\|180607
NZ_CP028494.1\|WP_107906281.1\|983871_984051_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028494.1\|WP_107906063.1\|992768_993155_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028494.1\|WP_107906283.1\|990800_991898_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP028494.1\|WP_107906068.1\|996386_997226_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP028494.1\|WP_107906065.1\|994226_995162_+\|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl\|CDD\|235467
NZ_CP028494.1\|WP_107906067.1\|996006_996270_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028494.1\|WP_107906284.1\|992505_992730_-\|DUF4031-domain-containing-protein	unknown	unknown	gnl\|CDD\|379076
NZ_CP028494.1\|WP_107906062.1\|991996_992470_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP028494.1\|WP_107906059.1\|987113_988067_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NZ_CP028494.1\|WP_107906057.1\|982182_983826_+\|helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP028494.1\|WP_107906060.1\|988133_988829_-\|copper-homeostasis-protein-CutC	unknown	unknown	gnl\|CDD\|225684
NZ_CP028494.1\|WP_107906055.1\|980618_980834_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028494.1\|WP_107906053.1\|975730_977371_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270371
NZ_CP028494.1\|WP_107906282.1\|986472_986871_-\|ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|198080
NZ_CP028494.1\|WP_107906066.1\|995187_996018_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381314
NZ_CP028494.1\|WP_107906058.1\|984344_986393_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226482
NZ_CP028494.1\|WP_107906054.1\|977579_980240_+\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|379300

Protein	Function_ID	Function_description	E-value
NZ_CP028494.1\|WP_107906061.1\|990098_990749_+\|hypothetical-protein	gnl\|CDD\|226789	COG4339, COG4339, Uncharacterized protein conserved in bacteria [Function unknown].	5.30516e-49
NZ_CP028494.1\|WP_107906064.1\|993210_994113_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	9.03351e-68
NZ_CP028494.1\|WP_107906056.1\|980811_982032_-\|TIGR00645-family-protein	gnl\|CDD\|180607	PRK06526, PRK06526, transposase; Provisional.	5.07012e-84
NZ_CP028494.1\|WP_107906062.1\|991996_992470_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.35154e-19
NZ_CP028494.1\|WP_107906283.1\|990800_991898_+\|N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	8.92681e-19
NZ_CP028494.1\|WP_107906065.1\|994226_995162_+\|N-acetylmuramic-acid-6-phosphate-etherase	gnl\|CDD\|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	6.9892e-160
NZ_CP028494.1\|WP_107906284.1\|992505_992730_-\|DUF4031-domain-containing-protein	gnl\|CDD\|379076	pfam13223, DUF4031, Protein of unknown function (DUF4031). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	6.30549e-25
NZ_CP028494.1\|WP_107906068.1\|996386_997226_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.97942e-06
NZ_CP028494.1\|WP_107906059.1\|987113_988067_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.01667e-20
NZ_CP028494.1\|WP_107906057.1\|982182_983826_+\|helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	4.02085e-108
NZ_CP028494.1\|WP_107906060.1\|988133_988829_-\|copper-homeostasis-protein-CutC	gnl\|CDD\|225684	COG3142, CutC, Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism].	1.35917e-23
NZ_CP028494.1\|WP_107906053.1\|975730_977371_-\|hypothetical-protein	gnl\|CDD\|270371	cd13653, PBP2_phosphate_like_1, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	8.77367e-39
NZ_CP028494.1\|WP_107906282.1\|986472_986871_-\|ANTAR-domain-containing-protein	gnl\|CDD\|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	1.30587e-14
NZ_CP028494.1\|WP_107906066.1\|995187_996018_+\|aldo/keto-reductase	gnl\|CDD\|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	2.77368e-114
NZ_CP028494.1\|WP_107906058.1\|984344_986393_+\|AAA-family-ATPase	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	1.69627e-66
NZ_CP028494.1\|WP_107906054.1\|977579_980240_+\|DNA-binding-protein	gnl\|CDD\|379300	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.	3.63758e-43

>NZ_CP028494.1|WP_107906060.1|988133_988829_-|copper-homeostasis-protein-CutC
MSKRAVLEVIALGVEDAVAAQAGGADRLELVTDMAADGLTPPVETFAGIRAAVDIDLRVMLRLADGFAVGDVERVVRTARAMRDAGADEFVLGFLDADGGVDLEAVERVVGVLGGCRWTFHRAIDRAADRDALRKQLDGMPGLDTYLTAGSAEGVDDGLPTLLAEAVRGGEPGYEQRILVGGGLRLDHVPTLLDAGIDAFHIGGAARPEGWTGPVSATAVAQWRAVLDGGA
>NZ_CP028494.1|WP_107906059.1|987113_988067_+|AraC-family-transcriptional-regulator
MQTLTFDSDDMGRTEEFLSRAYARMRIGNGSTGAGRARIERNAIESVSVDELDLDFDMSYSVTPLGRICLCLMHEGTIEDHTVHGVRDSFGPGDVVYFAPPELPYEGRVCGARYNITMLDPALLSQVAAGATGGGAVRLTGHRPHSREAADRLRQTIVHLRDHVLAVPAVADQPLVASTAAQHLAASVLATFPNSALTEPTGSDRQDAHPAALRRALTHIDDHADRPVTVAEIAEAAHVTVRALQYAFRRHLDTTPLAHLRTVRLSHAHQALLAADPGEGVTVTEIAARWGFHHPGRFAALYRECYGHSPHRTLHGS
>NZ_CP028494.1|WP_107906282.1|986472_986871_-|ANTAR-domain-containing-protein
MTDNKDLLDEITALQREVEQLRHALVSHAVVDQAIGVLRAVHGLDGQESWDVLQRVSQNTNVKLREVAEDVLRWAASGRLPDGIDPALREAVTAVDPTLRRPVLAPGHRGPRGTARPAPSGAEQWADGAATP
>NZ_CP028494.1|WP_107906058.1|984344_986393_+|AAA-family-ATPase
MSTPVDDPLDPLSRERSHLAGSRAALRAMREDVESLDISDVTANWVNAEVLARQIDDRIKALADLSDTPLFFGRLDYLHALGAEQAEGAEGERFYIGRRHVHDAEGDPMVIDWRAPVSQPFYRASKKDPLDIGLRRRFGYTGGDLTAYEDEHLSDPAEAARTSKLLQQEIERPRVGPMRDIVATIQPEQDEIVRSGLGGTVCVQGGPGTGKTAVGLHRVAYLLYAHRERLARTGTLVIGPNKSFLHYIEQVLPALGELSVRQATVDDLVAHVEVRGADDSTAAVVKGDARMAEVLRRAVYSHVTVPTEPVVVVRGSRRWRVPAYELEETVRELLDRGIRYGAAREALPQRIAHAVLVQMERSGEAPDDRVQDAVARNSAVKAAVKAIWPPVDPAKLVLRLLTDADFLAGHAAEILSEDEQKTILWAKPVRSVKSAKWSAADAVLIDEVNDLVSRTASLGHVVLDEAQDLSPMQYRAVGRRCTTGSATILGDLAQGTTPWATRSWDEALAHLGKSEGVIEELTAGFRVPTDVIAYASRLLPHIAPGLAPVASIRENPGFFEVREVSGTAEVVSACGELLCQEGSIGLIAADARIPALSEALTEAGLTYLAPGEETTRQTRLTLVPASLAKGLEYDYVLLDEPQAVVDGEPDERTGLRRLYVALTRAVSGLVVVHGAGLPVQLG
>NZ_CP028494.1|WP_107906281.1|983871_984051_-|hypothetical-protein
MSAATIHPAPAGARGATALQGSHRHRFGEALRAVRVFAGAAFDVIVLGEYGEEAGVRHK
>NZ_CP028494.1|WP_107906057.1|982182_983826_+|helicase
MNGPLIVQSDKTLLLEVDHEQADACRRAIAAFAELERAPEHIHTYRVTPLGLWNARAAGHDAEQVVDALVTYSRYPVPHALLVDIADTMDRYGRLTLSKHPTHGLVLTSTDRPVLEEVLRSKRIAPLVGPRIDPDTVAVHPSERGQIKQTLLKLGWPAEDLAGYVDGEAHPIELNEDGWALRPYQKQAVENFWHGGSGVVVLPCGAGKTLVGAGSMAQAKSTTLILVTNTVSARQWKHELMKRTSLTEEEIGEYSGTRKEIRPVTIATYQVLTTKRKGVYPHLELFDSRDWGLILYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTESERLAYATAEQEEKYRFCATTDTKRKVTEALVRRFAGQQILVIGQYIDQLDELGEHLNAPVIKGETSNAQREKLFGAFREGEISVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHKAHFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIVDADEILAEG
>NZ_CP028494.1|WP_107906056.1|980811_982032_-|TIGR00645-family-protein
MPNVQAIDREPSPPTTTLGFALFATRWLQAPLYFGLVAAQGVYVYKFFNELWALILRCVTGQATETYVMLAVLKLVDVVMIANLLIMVIVGGYETFVSRIGLQGHRDQPEWLSHVNSNVLKVKLATAIVGISSVHLLQMFVDVHRTSHHSLMWGTVIHMAFIASAAILAYMSGPMAAQAERAHQQTHHHEPGPEAPAAKVFVPAQSGPREDAPSAEERLRAAGFPARKLLEDFDSEHPRAFDRETVARLGKLDFVTAGRNVVFVGPPGTGKTHLAVGLGVRACQAGHSVLFASAAEWAARLAAARDAGRLARELTALDAHALLIVDEVGYTPFDPETAALFFQLVAHRYERASLIVTSDRPLARWDEVFGGPSALAMADRLAHHADLVRIEGESYRMRRATSAWAD
>NZ_CP028494.1|WP_107906055.1|980618_980834_+|hypothetical-protein
MRSERTARSRTALSVAVLSAAAALVTALAPAAAAAPSLPLPLPAAGSESLVTEGLTIEGPLINNVSLPTLR
>NZ_CP028494.1|WP_107906054.1|977579_980240_+|DNA-binding-protein
MSDPATPPRSLAEDLRVRDDASLTMLLRSRPDLITPVPTDLTQLATRAGTRASVVRALERLDRFALQTAEALAVAADPATYDELLALMAGDEGDPAVTGALPHALGTLREQALVWGADDRLRLVRTARELLTPSPQHPSPTGLGPTVQEATAGMSPGRIQEIVTTAGLPSTHDAVSAVSALTALFTDRTRMTALLADAPEESREVLARLVWGPPYGQVTADPAARLRWLLDRGLLLPTAPGTVVLPREVALHLRSGRAHRATEPLPPPVEPASTHGPQVVDTTAAGQAYTALATVEELLKDWHEGGPAVLRAGGLSVRDLKRTAVALDVPEPVAAFWTELAYAAGLLASDGEADERFAATPAYDEWLEQPAAERWARLAESWLAATRTAGVVGGRDAKDRTLSALGPGLDRSAAPEVRHRVLTLLAGLPQGASPAPESVLARLRWERPLRGPQRDDDLRARLARWTLNEAELLGVTGRGALSAQGRALLGAPEAGPGGQPGGRGRSTGPSATGPTGATTDPTTATTHDTTPAGPTPPAGASTGPGDKLPVHHEHPRPAGPSEPLSPVEQAVASAAAARLLAPLLPEPLDHVLLQADLTAVAPGPLRRPLADTLGVLADVESKGGATVYRFTPGSVRRALDAGRSASDLHAFLAEHSRTPVPQPLAYLIDDVARRHGHLRVGAASAYVRCDDDAVLNEILADKRAAGLRLRRLAPTVLAAQADPAGLLEGLRAMGFAPAAESAEGDVLITRADAHRTPPRSAPEPVPDGPPTPDATLLVAAVRAIRAGDLASTTPRKPSGAATAMTGGELPRTTPAETLATMQAAVLTGESLWIGYVNAEGSASQRVIAPVRVEGGFVTAYDHTADEVRTYPLHRITGVAELADDQI
>NZ_CP028494.1|WP_107906053.1|975730_977371_-|hypothetical-protein
MSEQAEQWIAILSLAFPVAAFLWEFAVVGRKRLGYRVQMDTLAADAADKPYADVLGDMRHDGHQLKDPSFVLLRIENAGSTKIVSEDYLADPADPYGIKVTFRDRRVAAVVLTDPSNNALRDFFFEEVTEGDSVRTVAKPGFRRNNNAVDRTGTIRLPKVTLPRGAEYKVLVVLERWPADTGTDPFPDPVVQGTDGQERWYDPLIRLLRLKATRTESHVFASRPAWWVIWILIAAVAVQANFTLFVREDKRPPLDCVKGTLYLHGSTAFAPAVRAAAQDYLARCDGADVHIPLADDTFKGSTDGVTDLDEAGKEAGIPVGEGLRDHLAFTDGLASDGHPRLIPRPVALSVFTLVVNKDAGVENLKLDQIRDVFAGRVKNWSDIGGNDVPVHLVNRDPGSGTRSTLVAKVLAGKEPPQFTETDCAALDPKRYGRCEVTSTDTMLNTTASTPGAVGYSEATAVAGHRAADGLVKVTIDGRQPTAEGVGTTNYPYWQTEFAYTYGEAPAGSVAAAFLNFLTQQSGRDILRDHGHGLCSEVQNSGECRPA
>NZ_CP028494.1|WP_107906061.1|990098_990749_+|hypothetical-protein
MPDLDTDALRTRFTRTLDSARSPLAAPAPTPYADALLTRWQEPQRRYHTLAHLTAVLDRVDELAGYADDPDVVRLAAWFHDAVYLPDRSENEERSARLAERALTEAGVPADRTAEVARLVRLTVTHDPAPNDRDGQVLCDADLAILAAPPSAYASYTAAVREEYHFVPSDAFREGRAAILRQLLDLPSLFRTPHGRKEWEATARYNLAGELEMLSP
>NZ_CP028494.1|WP_107906283.1|990800_991898_+|N-acetyltransferase
MNEAVTDAVAVLRTAVDRDWAGVKAGRLDWTCRDTAEHISSDLIAYAGQLAGRAQSAYVPFEITLDEGTDNEGLLHVIETTGALFSATIRTTPHEVRAFHPYPFRSANREGFAAMGIAEVLLHTHDIAEGLGLAYEPPAELAEFVLTTIFPHVRPGPDHWRTLLWATGRGDLPGRPPVTEWRWNNNLVIPTDRLTLQGVTPAAATDLHTGGDGGFEWVDGGPFQGTRDAAGMVVKAYGEGVHRPEWGLFVLVRRQDGRAIGGIGFHGVPDEEGHAEVGYDLTEAARGQGYATEALRALSDHSLTGAEAHALIAAIHEDNAPSQGVATRAGYVRASVEEERTAYEEHDMDRELRLYVRRSARQQRQ
>NZ_CP028494.1|WP_107906062.1|991996_992470_+|carboxymuconolactone-decarboxylase-family-protein
MSARLNALEIPTVGKFVKYIASAGKVIHDSSLPVATQNMVTLRASQINGCGFCTDMHFKDAVAAGEDTVRLNLVAAWREATVFTEAERAALELTEAGTRIADAAGGVPDDVWENAAKHYDEEQLGALVSLVALINAFNRMNVIVQQPAGSYQPGQFA
>NZ_CP028494.1|WP_107906284.1|992505_992730_-|DUF4031-domain-containing-protein
MWSHLVSDLSYDELHMFAEKLGVPRRAFERDHYDIPSHRYADAVRAGAVEVSSREVVRLLQGAGLRRPKGRDWG
>NZ_CP028494.1|WP_107906063.1|992768_993155_-|hypothetical-protein
MEPVTPLEQALHTARALVLADLVAGEAAEADVVSLVEEAVVQRRWWVEQWPDGVEYVAGLVAQDVQDALLDRFGRWPLCPVCGDGDPHALEVEPELGPDPHWVCHQAGVKVAAVGSLGPAAAGGTPAS
>NZ_CP028494.1|WP_107906064.1|993210_994113_+|MurR/RpiR-family-transcriptional-regulator
MPHEVKETFDRAPAPAALAAKVRTLAPSMTRSMQRVAEAVANDPAGCAALTVTGLAELTGTSEATVVRTARLLGYPGYRDLRLALAGLAAQQQSGRAPAITTDIAVDDPIADVVAKLAYDEQQTLADTAAGLDTVQLGAAVSAAATARRIDVYGVGASGLVAQDLAQKLLRIGLIAHAHSDPHLAVTNAVQLRAGDVAIAITHSGSTGDVIEPLRVAFEHGATTVAITGRPDGAVTQYADHILTTSTARESELRPAAMSSRTSQLLVVDCLFVGVAQRTYDTAAPALAASYEALAHRHRR
>NZ_CP028494.1|WP_107906065.1|994226_995162_+|N-acetylmuramic-acid-6-phosphate-etherase
MTSASTPRNLRAELDTLTTEAFRPELAEIDQLATLDIARLMNGEDASVPAAVASRLPEIAAAIDAVAERMARGGRLVYAGAGTAGRLGVLDASECPPTFNTDPTEVVGLIAGGPEAMVTSIEGAEDSEDLARTDLDALMLTPDDTVVGISASGRTPYAVGAVEHARGQGALTIGLSCNPGSALAAAAEHGIEVVVGPELLTGSTRLKAGTAQKLVLNMLSTITMIRLGKTYGNLMVDVRASNEKLRARSRRIVALATGATDPDIERALTEAGGEVKTAILILLADTDGPTATRLLTDSGGHLRAALKSAGE
>NZ_CP028494.1|WP_107906066.1|995187_996018_+|aldo/keto-reductase
MTASETFLIGGDLEVRRLGFGAMHLRPEPAEDRAAAVAVARRAVELGVTLIDTAHMYGWGANEDLLSEALHPYPDDLAIATKVGFRQTTTDQGWRYAGAPDELREQVDEALRRLRLDRIDLLQLHRLDPGVPLADQLGALRDLRDEGKIARIGLSEVDEGELAAARAVVDIASVQNRYNLLDREHEPVLKACEEAGIAFLPWRPVAAGASGAQSEQIATIAKELDATPTQVAIAWLLAHSPVIVPIPGTSSIAHLEENVGAAAVHLSQDQYDRLTR
>NZ_CP028494.1|WP_107906067.1|996006_996270_-|hypothetical-protein
MRSTEEVVALLREALGGVGVVLPSLCVDPVTGAGEEPFALVQLGRCNVRTAERLVAVLRGEPLEPAPAKEELLERVRRVNRAGRLPR
>NZ_CP028494.1|WP_107906068.1|996386_997226_+|XRE-family-transcriptional-regulator
MPGPKDLDPSSSPRALLGAELRHAREKAGLSQEKLGLLLFASGSFVGQLEAGTRRIQPEQARLLDAALGTGDFFQRNFRVASKSKYPEHFAEAADAETEATAIREYAPLLIPGLLQTPAYARAVNRAYDPIAPEEIIEDWVEGRMARTRLLDHPTKPLLWAVLDEAALRRVTGGRSVMAEALRHIAALARRNRVIVQVLQFSAGAHAAMKGSLKLMEFEDAPPLAYLEGVGTGRLEDDPATVAHMKFTYELLAAAALSPEKSLALIDALAQDYSHDEHP

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1117373 : 1127731

Bacillus_phage(37.5%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_107906164.1\|1117373_1118153_+	DNA-binding response regulator	W8CYM9	Bacillus_phage	1.6e-16	38.0
WP_107906165.1\|1118280_1119303_+	LacI family transcriptional regulator	C6ZCU4	Enterobacteria_phage	2.5e-25	29.7
WP_107906166.1\|1119439_1120498_+\|protease	serine protease	W5SAB9	Pithovirus	6.7e-05	34.1
WP_107906167.1\|1120509_1120698_+	hypothetical protein	NA	NA	NA	NA
WP_107906168.1\|1120763_1121501_+	DNA-binding response regulator	W8CYM9	Bacillus_phage	1.5e-35	38.2
WP_107906169.1\|1121497_1122931_+	sensor histidine kinase	W8CYF6	Bacillus_phage	3.9e-24	29.0
WP_107906170.1\|1122905_1123265_-	hypothetical protein	NA	NA	NA	NA
WP_107906171.1\|1123261_1123612_-	hypothetical protein	NA	NA	NA	NA
WP_107906172.1\|1123830_1124052_-	DUF397 domain-containing protein	NA	NA	NA	NA
WP_107906293.1\|1124048_1124831_-	XRE family transcriptional regulator	A0A1J0MCL6	Streptomyces_phage	9.1e-15	28.4
WP_107906294.1\|1125063_1125321_+	hypothetical protein	NA	NA	NA	NA
WP_107906173.1\|1125317_1125596_+	hypothetical protein	A0A291LIC9	Streptomyces_phage	2.2e-08	43.0
WP_107906174.1\|1125664_1127731_+	pectate lyase	A0A076FMJ8	Aureococcus_anophage	1.8e-14	27.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

7. NZ_CP028497

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP028497_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028497_1

491303-491382

Orphan

Consensus_repeat	Method
GAGGCCCACGGTCACGTCTCGGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028497_1

>merge|NZ_CP028497|1|491303-491382|CRISPRCasFinder
GAGGCCCACGGTCACGTCTCGGTCCTTAGGGGCGCGGGGAACTGCGCAACGTTTATGAGGCCCACGGTCACGTCTCGGCG

>NZ_CP028497|1|1|491303-491382|CRISPRCasFinder
GAGGCCCACGGTCACGTCTCGGTC	CTTAGGGGCGCGGGGAACTGCGCAACGTTTAT
GAGGCCCACGGTCACGTCTCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028497.1\|WP_107906808.1\|491455_492109_-\|deaminase	unknown	unknown	gnl\|CDD\|223340
NZ_CP028497.1\|WP_107906809.1\|492236_492872_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028497.1\|WP_107906799.1\|478105_479071_-\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|235821
NZ_CP028497.1\|WP_107906806.1\|486047_486629_+\|UPF0016-domain-containing-protein	unknown	unknown	gnl\|CDD\|225030
NZ_CP028497.1\|WP_107906811.1\|493171_493618_-\|DUF1992-domain-containing-protein	unknown	unknown	gnl\|CDD\|378159
NZ_CP028497.1\|WP_107906810.1\|492835_493183_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028497.1\|WP_107906815.1\|498326_499997_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378217
NZ_CP028497.1\|WP_107906816.1\|500285_501443_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340391
NZ_CP028497.1\|WP_107906805.1\|484992_485637_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|377857
NZ_CP028497.1\|WP_107906813.1\|494891_496013_-\|DUF2330-domain-containing-protein	unknown	unknown	gnl\|CDD\|370813
NZ_CP028497.1\|WP_107906803.1\|480938_482867_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|379196
NZ_CP028497.1\|WP_107906807.1\|486867_487545_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319829
NZ_CP028497.1\|WP_107906817.1\|501439_501841_+\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|367422
NZ_CP028497.1\|WP_107906802.1\|480410_480848_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP028497.1\|WP_107906800.1\|479107_479350_+\|DUF2277-domain-containing-protein	unknown	unknown	gnl\|CDD\|378364
NZ_CP028497.1\|WP_107906814.1\|496321_498373_+\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|379588
NZ_CP028497.1\|WP_107906801.1\|479545_480169_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP028497.1\|WP_107906804.1\|483233_484862_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|277335
NZ_CP028497.1\|WP_107906812.1\|494118_494790_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP028497.1\|WP_107906798.1\|477623_478097_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP028497.1\|WP_107906808.1\|491455_492109_-\|deaminase	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	2.65786e-09
NZ_CP028497.1\|WP_107906799.1\|478105_479071_-\|2-dehydropantoate-2-reductase	gnl\|CDD\|235821	PRK06522, PRK06522, 2-dehydropantoate 2-reductase; Reviewed.	4.34837e-50
NZ_CP028497.1\|WP_107906806.1\|486047_486629_+\|UPF0016-domain-containing-protein	gnl\|CDD\|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	2.29079e-26
NZ_CP028497.1\|WP_107906811.1\|493171_493618_-\|DUF1992-domain-containing-protein	gnl\|CDD\|378159	pfam09350, DUF1992, Domain of unknown function (DUF1992). This family of proteins are functionally uncharacterized.	1.74384e-19
NZ_CP028497.1\|WP_107906815.1\|498326_499997_-\|hypothetical-protein	gnl\|CDD\|378217	pfam09594, GT87, Glycosyltransferase family 87. The enzymes in this family are glycosyltransferases. PimE is involved in phosphatidylinositol mannoside (PIM) synthesis, a major class of glycolipids in all mycobacteria. PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of PIM. The family also includes alpha(1-->3) arabinofuranosyltransferase, invloved in the synthesis of of mycobacterial arabinogalactan.	0.000182958
NZ_CP028497.1\|WP_107906816.1\|500285_501443_+\|ATP-binding-protein	gnl\|CDD\|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	6.71055e-16
NZ_CP028497.1\|WP_107906805.1\|484992_485637_-\|HNH-endonuclease	gnl\|CDD\|377857	pfam07510, DUF1524, Protein of unknown function (DUF1524). This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	1.96264e-10
NZ_CP028497.1\|WP_107906803.1\|480938_482867_-\|FAD-binding-protein	gnl\|CDD\|379196	pfam13454, NAD_binding_9, FAD-NAD(P)-binding.	1.93076e-44
NZ_CP028497.1\|WP_107906807.1\|486867_487545_+\|HAD-family-hydrolase	gnl\|CDD\|319829	cd07527, HAD_ScGPP-like, subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). This subfamily includes Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). GPP1p and GPP2p are involved in glycerol biosynthesis, GPP1 is induced in response to both anaerobic and hyperosmotic stress, GPP2 is induced in response to hyperosmotic or oxidative stress, and during diauxic shift; overexpression of DOG1 or DOG2 confers 2-deoxyglucose resistance. These belong to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.35556e-74
NZ_CP028497.1\|WP_107906817.1\|501439_501841_+\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	1.51343e-18
NZ_CP028497.1\|WP_107906802.1\|480410_480848_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.25585e-14
NZ_CP028497.1\|WP_107906800.1\|479107_479350_+\|DUF2277-domain-containing-protein	gnl\|CDD\|378364	pfam10041, DUF2277, Uncharacterized conserved protein (DUF2277). Members of this family of hypothetical bacterial proteins have no known function.	1.8107e-25
NZ_CP028497.1\|WP_107906814.1\|496321_498373_+\|DUF2029-domain-containing-protein	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	1.39975e-44
NZ_CP028497.1\|WP_107906801.1\|479545_480169_-\|hypothetical-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	2.43566e-14
NZ_CP028497.1\|WP_107906804.1\|483233_484862_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|277335	cd07389, MPP_PhoD, Bacillus subtilis PhoD and related proteins, metallophosphatase domain. PhoD (also known as alkaline phosphatase D/APaseD in Bacillus subtilis) is a secreted phosphodiesterase encoded by phoD of the Pho regulon in Bacillus subtilis. PhoD homologs are found in prokaryotes, eukaryotes, and archaea. PhoD contains a twin arginine (RR) motif and is transported by the Tat (Twin-arginine translocation) translocation pathway machinery (TatAyCy). This family also includes the Fusarium oxysporum Fso1 protein. PhoD belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.54409e-32
NZ_CP028497.1\|WP_107906812.1\|494118_494790_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	1.59103e-57
NZ_CP028497.1\|WP_107906813.1\|494891_496013_-\|DUF2330-domain-containing-protein	gnl\|CDD\|370813	pfam10092, DUF2330, Uncharacterized protein conserved in bacteria (DUF2330). Members of this family of hypothetical bacterial proteins have no known function.	6.33541e-81

>NZ_CP028497.1|WP_107906807.1|486867_487545_+|HAD-family-hydrolase
MTATAAPTESTVITARALLLDMDGTLVNSDAVVERIWRRWAERHGLDGDEVMKVVHGRQGYASMALLLPDRPMEQNHADNARMLAEETADVDGVVPIPGAPEFLASLRGLPHALVTSADVALSTARMAAAGLELPDVRVTAESVGASKPDPEGFLKGAAELGVAPADCVVFEDSGAGIEAGRSAGMRVVGVGARAGFHGPDVLVRDLRQVRVEAVDGGGVRLFIA
>NZ_CP028497.1|WP_107906806.1|486047_486629_+|UPF0016-domain-containing-protein
MISFTVTAVVFGVVFLAELPDKTALAGLVLGTRYRASYVFAGVAAAFAVHVALAVAAGSVLTLLPQQILHALTGVLFLGGAAVLLMKKDEDEGEVRKPENQSFWKVSGAGFMLILVAEFGDLTQIMTANLAARYDDPLSVGIGAVLALWAVAGIGIVGGKALMKRVPLKLITKVAALVMLTLGLWSLYEAIAG
>NZ_CP028497.1|WP_107906805.1|484992_485637_-|HNH-endonuclease
MSKFYARRRVSILAALSGLIASVALFNAPTASAALPTPVSAATARTYLASLTVAAEDRTGYDRDLFPHWITQSGACNTREVVLKRDGTNVVQDSSCAATSGSWYSVYDGATWTAASDLDIDHLVPLAEAWDSGADSWTTSRRQSFANDLTRPQLIAVTDNVNQAKGDQDPATWMPSRTAYRCTYVRAWVQVKYYYGLSVDSAEKSALTNYLASC
>NZ_CP028497.1|WP_107906804.1|483233_484862_-|alkaline-phosphatase-family-protein
MAELRLGPLLRYVDGSTATVWVEASRPCAVRVRGADGSGGEARTFQVAGHHYALVPVTGLTPGTTTPYEVHLDGTGVWPLPGSPFPPSVIRTPADGDPVRLAFGSCRWAAPPADEKDPVGPDALDTLAARMAADPDGERPDVLVLLGDQVYADETSNATRRWLAARRDLSEPPGNEVADYEEYTRLYYESWLDPEVRWLLSTVPSCMIFDDHDVIDDWNTSAAWLADMRATPWWRERLLSGLMSYWVHQHLGNLSPAELAADPLFAAVREAPDGTDELRSFACKADADPASVRWSYRRDFGRVRLLMVDTRAARVLDEEARSMLDPGEARWLREQALDAPGSYDHLLIGTSLPWLLPHLVHDAEAWNAALCRGERGERWARFGEDLRRRADLEHWAAFPSSFDALTELIAEAGSGPDAPATVCVLSGDVHHAYIAEPAWPAGTGPDARVLQLTCSPVHNAIPLAIRLGFRFGWSGLARVLGRRFAGHGGCPKPPIDWRRTGGPWFGNQLMTLTLGRRSARLRLEQARGAARLDVVAESQLTP
>NZ_CP028497.1|WP_107906803.1|480938_482867_-|FAD-binding-protein
MRPTRPGVTPLTAPTPAPTSVSVALVGAGPRGTSVLERLCACAPELLPPGARLTVHVIDPAPPGPGRVWRTAQSPELLMNTVASQVTLFTDESVDCSGPIRPGPSLYDWAAGELGPDEYPTRAQYGRYLEWVFAKVVHEAPPTVRVETYATRAVRLDDAPDGRQTLTLDNGRVLPGLSAVVLAQGHLPTAADTAQRHLAAHAERHGLRYVAPANPADVDLSAVSPGEPVLLRGLGLNFFDHMALLTTGRGGRFVRDDEDLRYLPSGNEPRLYAGSRRGIPYQARGDNAKGPYGRHLPLVLTPEVIAGFRKRADSGEAPDFLAEIWPLVAKEVETVYYAALITGAGRPEFTERFLAVPHRDPQETLLLDEFGIPERERWSWDRVSRPYGEYGFPDRGRWRDWLLAYLREDAAQAARGNVHGPLKSALDVLRDLRNELRLIVDHAGLTGTSRRDHLDRWYTPLNAFLSIGPPRRRVEELVALMEAGVVEVLGPRPEVREEADAWVAHSPEVPGSVVRATTLVEARLPEPDLRRTADELLARLLKTGQCRPHTVDGYETGGLDVTARPYRLIDRQGQPHARRFAFGVPTEGVHWVTAAGARPGVDSVTLSDADAVARAALRAVIPGTEGDAGTQVWPNVELASID
>NZ_CP028497.1|WP_107906802.1|480410_480848_-|DoxX-family-protein
MTGRLNSAQPYAIGLFRIVVGLLFACHGANSLFGAFGGETPDTGAWPAWYAAVIELVGGSLVLLGLGTRAAAFISSGAMAYAYFKVHQPQALWPIENSGEGAAMYCWAMFLLIFTGSGAFGLDRLFTKRSTAQSSTATDQTPVAA
>NZ_CP028497.1|WP_107906801.1|479545_480169_-|hypothetical-protein
MLEGIEDVGALTAGPWIYVVVAVSVLLDVFVPVLPSGVLVITAATAAAAGSGAATGEVPGEVPDILALTLCAATASVLGDLVAYRVARRGGARLDRAIARSRRLSAAQERLGAALARGGGALVVLARFAPAGRSVVSLGAGATHRRVRDFLPWSALAGLAWAVYSVALGYFGAQWLGATWLATAVSVAALFAAGAGATYLVRREPSA
>NZ_CP028497.1|WP_107906800.1|479107_479350_+|DUF2277-domain-containing-protein
MCRSIKTLRPPVLPEEATEEEIRAAALQYVRKVSGFRAPAAHNREVFDRAVEAIAEATAELLDGLEVRGAPATARGAAAG
>NZ_CP028497.1|WP_107906799.1|478105_479071_-|2-dehydropantoate-2-reductase
MITSGAATAEGAGPTDERMRMTANDGLTVAILGPGGIGGLLAALLSRSGHRVICLAGDETAKTLSAKGIRVRSGLFGDFTAPVEADTELREPVDACLIAVKATALDASLTRVPPAVLGDGLVVPFLNGVEHPGLLRARYRADRVAPAAIRAESTRVAPGEIEHGTPFAEIDLTGDPVPDDRLAALGQVLDAAGPTTRVHADEAATLWSKMSLLAPFALLTTRYALPIGDVRTQHREELLALVDESTAVSAACGGPSDPSMAIARYDAFPATTKSSMQRDAEAGRPLELDAIGGALLRAADRHEVPVPVATRLVGELRAAGH
>NZ_CP028497.1|WP_107906798.1|477623_478097_+|hypothetical-protein
MAGPGDGFRLMRGSTGFFTSGDPGIRRTDPRACRTAWYAAARAAGGRVGEFEARQIAQTFHTATIERPDGRCCALFQAYTPLVAFVDEPHDWYTDQFREAPAWAAGLGDFGFTVLSAAVLLSPLSSADTSALSAVERRQIDYWRPETVGAVLFNSWD
>NZ_CP028497.1|WP_107906808.1|491455_492109_-|deaminase
MSLVRVHNFTISLDGFGTGEGLSLDAPFGHAGERLHEWMFATRWWRERTGESGGNGGVDDAFARQFMPGIGAEIMGAGKFGYPGWHENPDWKGWWGPNPPFHTPTFIATRHTRPSIEMEGGTTFHFLNASPAEVLAAARKAAGDQDIRIGGGVRLLRDFLSARLIDHAHIVVSPILLNRGQRLWDGLEGLEQHYATESIASPSGVTHLTLTLRDQTA
>NZ_CP028497.1|WP_107906809.1|492236_492872_+|hypothetical-protein
MSTVVIILIVIAAVVVLGVTVMALRTRGAQGGRSLKRRFGPEYERTVARHDGDAKAAERELAQRVERHGGLRERTLETTEVERYEARWTAAQERFVDSPKDAVDEADRLLAELAQARGYPDGAQYEEQLSALSVHHANRVRGYRRVHRAARAGAEGGPGTEEMREAMVEARALFEELVAVPVERHREPHEAQKKTGSHTPWSFTGRQAKGS
>NZ_CP028497.1|WP_107906810.1|492835_493183_+|hypothetical-protein
MVVHGASGEGELSHMTDVTTGSGPGHVRLVPDDESDKFELRLQHAVSGFVDGPRAAVEEADQVVEAIVARFAETVRERRRTLRTSWQDTEEKADTERLRLALRDYRELAERLLHI
>NZ_CP028497.1|WP_107906811.1|493171_493618_-|DUF1992-domain-containing-protein
MTERKPPGVPFESWVDKQIHDAQVRGDFDRLPGRGEPLPNDLEAPYDELWWVKRKMAREGLSVLPPALALRKEAEDALTAAYAAPSERAVRKIITDVNAKIRDMLLKPPPGPPLGRKPYDVEEVVRQWRERRATAGSGAPDGSRASDV
>NZ_CP028497.1|WP_107906812.1|494118_494790_-|O-methyltransferase
MSEPQVWDDVDEYFSSQLSPDDEILLAALRDSEAAGLPAISVTATQGKLLQLLAQIQGARNILEIGTLGGYSTIWMARALPSDGRLISLEYSARYAEVASRNIARAGLDKVVEVRVGPALESLPKLADENPAPFDLVFIDADKANNPHYVDWALRLTSTGSLIVVDNVVRGGRVVETDSDAPDVRGTRAAIELIGSHPRLSGTAIQTVGGKGYDGFALARVLA
>NZ_CP028497.1|WP_107906813.1|494891_496013_-|DUF2330-domain-containing-protein
MAESLRQGARGRALAIVLALLALQLGQLVAPAWACGCGAMVPGDARRVAVGREESVVRWDGAREQVVMRLTVDGDAERVAWIMPVPGRATVRLGDPALFDELHAVTAPVHRTRYHFWPQDGDWPLVAGDGAAGAPPPPGAGAPVGVVGRQRLGPFEVARLTATDPAALDGWLDANGFALPPRLADALRPYVDRRWEYVAVKLTPRAGGTALTGALDPLHLTFRTDEPVYPMRLSRLAATPQSLGLYVLAAHRMEPASRIGGERPRVTYAGRVTARTGPLAELAAGAPFLTAIGQEFPSPERISGDHVLRRAAADDTFRQVIHEDRLRTLAGVPLWLLTVTTALVAAIAAVVVFAVRRTRPRLPEVPRPPAPTG
>NZ_CP028497.1|WP_107906814.1|496321_498373_+|DUF2029-domain-containing-protein
MANADHGGRPEAIGATAVGAVQARVRVARLGLWLIVAVLALREVAVVLGTPRGERLTDLETWVGPDGVLHVKGSLYDSTEFTGTPFGGLVLKPLTRAAEQALGWGWTFGTLLLVVVLGLVAARALPQPVSRRTSLLAAPVAISLLMLSLPVRNTLYLGQTSIMPVLLVLLGCFAVRGERASGVLIGVAAALQPTLLLFTPLLWFTGRRRAALSTGATFAACTALAWVAMPSDSYTYWVHHMAGVGLGGRADDLGNQSLHGALLRLGLTGPLEIVLFLLLGAGVAALAVRRAVRYAHDGQLLLAVAITGCAAIVVSPTAWQHQLLWVLLAVVGQVGRRASDRYVWPVAIVLVMTLPAKMMVPDKLILHPLRADLVLLAAIAAAAVVPFLSRASPYWQTPVPTRYADKVPARFRHIPLVPFLRRVISRPNLLFELLLIRVTYYAYAQIRLAAAGGSNSAGRITAEEHGEEIHSVERALGIDIEHWANHAVVQVDWLRSFFDFYYESFHFGVPLAILAVLYWRRPVDYRWARTAIGFATVFALIGFWLYPLAPPRLMPGLGFIDTVHGPQDFTQPDYGTLTELTNQYAAMPSLHFGWSLWCGLVILILAPRWWMKALGLLHPLFTVTAIVVTGNHWVLDAVGGAAVVGAGFAVTYLFQGPRAKTVTARAEKVSSDSRAPVKDRTPS
>NZ_CP028497.1|WP_107906815.1|498326_499997_-|hypothetical-protein
MNVPTRNRVLAHMVPAELTRTRPAPPASEAGQSLPRTLWHRHRVPLLATLPALPLYAIWWAFLATGGGDLAAQYAWAGFAARHGDSAYNLFWYGGTHTANYSLISPYLMAAVGVRALTVVSGIAATWLAAVLMERAGLRRPLGPALLASFALWCNVASGRTTFALGVAFGLAACLMLTRDRRIVLAAAYAALATMASPVAGLFLVVVGAAFLVTRDWPRALALLLPPALTVGLTTLLFPFKGEQLMFAGRIWPPFLFGLAVTFLAPRSWRVARISGAVYAAGTVLTYLIASPIGTNVERFAELFAPAALLAVLLAQPQLAKVRRNLLVTALVLSVAWVGKKTADDLYVSTTVPAWAAETDGVVRALDHLGADRTRVEVVPARNHREASGLAPHVNMARGWNRQLDMERARLFYDGSFSATTYRAWLDRWAVGFVVLPLGKPDGYAKVEAQLVRENRPAWLEPVWQDAHWKVFRVRDAQPLVSEPATVVSTSSVDVVVRMPRPGSATVRIAYSQWLHTDGGGCLKPQGEFTRLTVSAPGEYRISSEYGPSPEPGSRC
>NZ_CP028497.1|WP_107906816.1|500285_501443_+|ATP-binding-protein
MTQYVMDPAIWGLVVGAPAAATIIVRQQKAIRKLRKRNDELKSSYVDLEGGYDAIVRQTEERAGEETKTVLKSAMRTLQGLAAEQQLVISKLQSKYGDSPILRDLLEIDHMNSQFGRRAQSIAVLCQGWLGRQRDPASVYDVIRSAQGRIRHYQRVEILSQVDYGVTSRAVESIALAVAELLDNATSYSAPETVVEINVRSVPKGICIVVDDAGVGMNEEEKARAAELLSGERAASVSDLGNPPQFGFAVIGALCERYGFTVSVDSTSPYGGVRAVVLVPEELLTSMPEPKIPNAAAHADAQADELGGDAPATTSDGLPKRRRKQRPMAVVPSSGGTARSPGRSTEETASIMSAFQRGTQTGRAAPLDAMRGSHADGRKGPETTS
>NZ_CP028497.1|WP_107906817.1|501439_501841_+|roadblock/LC7-domain-containing-protein
MKNDLSWMLDSALEIPGALHAVLVSADGLLMARTKDLGRDSADTVAAAMSGVQSLSRSLGFFVDGEHMQWRQTLVEFDGGWVFLISAGEGAYLAVSAAPEIDMADITFRMQQLVGQLGKELATSPREDIGHRS

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Crispr_ID: NZ_CP028497_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028497_2

535649-535764

Orphan

Consensus_repeat	Method
CCTGCGGCTGCCCACCGTAGGGCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028497_2

>merge|NZ_CP028497|2|535649-535764|CRISPRCasFinder
CCTGCGGCTGCCCACCCCCGAACGGCTGCCCGGCCTGCGGCTGCCCACCGTAGGGCTGCTGCGGCTGGGCGCCCGGGTACCCGTAACCACCCTGCGGCTGCCCGCCGTAGGGCTGC

>NZ_CP028497|2|2|535649-535764|CRISPRCasFinder
CCTGCGGCTGCCCACCCCCGAACGGC	TGCCCGGCCTGCGGCTGCCCACCGTAGGGCTGCTGCGGCTGGGCGCCCGGGTACCCGTAACCAC
CCTGCGGCTGCCCGCCGTAGGGCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028497.1\|WP_107906836.1\|529073_530144_+\|prenyltransferase	unknown	unknown	gnl\|CDD\|273702
NZ_CP028497.1\|WP_107906846.1\|540101_540752_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379276
NZ_CP028497.1\|WP_107906837.1\|530185_530473_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028497.1\|WP_107907366.1\|545821_546454_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP028497.1\|WP_107906840.1\|534305_535316_-\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274647
NZ_CP028497.1\|WP_107906839.1\|533561_534290_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028497.1\|WP_107906835.1\|528324_529077_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP028497.1\|WP_107906847.1\|540875_542636_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341047
NZ_CP028497.1\|WP_107906844.1\|538723_538957_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028497.1\|WP_107906832.1\|525601_525835_+\|ferredoxin	unknown	unknown	gnl\|CDD\|224064
NZ_CP028497.1\|WP_107906843.1\|538431_538737_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028497.1\|WP_107906834.1\|526930_528331_+\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP028497.1\|WP_107906848.1\|542848_544321_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP028497.1\|WP_107906838.1\|531967_533530_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|379243
NZ_CP028497.1\|WP_107906833.1\|526102_526720_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380056
NZ_CP028497.1\|WP_107906845.1\|539083_540037_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NZ_CP028497.1\|WP_107906850.1\|544924_545764_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028497.1\|WP_107907365.1\|530702_531971_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028497.1\|WP_107906842.1\|536525_538091_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|379519
NZ_CP028497.1\|WP_107906849.1\|544385_544928_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028

Protein	Function_ID	Function_description	E-value
NZ_CP028497.1\|WP_107906836.1\|529073_530144_+\|prenyltransferase	gnl\|CDD\|273702	TIGR01577, Uncharacterized_glycosyl_hydrolase_MJ1610, oligosaccharide amylase. The name of this type of amylase is based on the characterization of an glucoamylase family enzyme from Thermoactinomyces vulgaris. The T. vulgaris enzyme was expressed in E. coli and, like other glucoamylases, it releases beta-D-glucose from starch. However, unlike previously characterized glucoamylases, this T. vulgaris amylase hydrolyzes maltooligosaccharides (maltotetraose, maltose) more efficiently than starch (1), indicating this enzyme belongs to a class of glucoamylase-type enzymes with oligosaccharide-metabolizing activity.	3.92266e-14
NZ_CP028497.1\|WP_107906848.1\|542848_544321_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.48328e-68
NZ_CP028497.1\|WP_107907366.1\|545821_546454_-\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.01872e-61
NZ_CP028497.1\|WP_107906840.1\|534305_535316_-\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274647	TIGR03559, F420_Rv3520c, probable F420-dependent oxidoreductase, Rv3520c family. Members of this protein family are predicted to be oxidoreductases dependent on coenzyme F420. The family includes a single member in Mycobacterium tuberculosis (Rv3520c/MT3621) but four in Mycobacterium smegmatis. Prediction that this family is F420-dependent is based primarily on Partial Phylogenetic Profiling vs. F420 biosynthesis. [Unknown function, Enzymes of unknown specificity].	3.2246e-167
NZ_CP028497.1\|WP_107906835.1\|528324_529077_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.12316e-26
NZ_CP028497.1\|WP_107906847.1\|540875_542636_-\|MFS-transporter	gnl\|CDD\|341047	cd17504, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.64135e-74
NZ_CP028497.1\|WP_107906846.1\|540101_540752_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379276	pfam13578, Methyltransf_24, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.65978e-22
NZ_CP028497.1\|WP_107906832.1\|525601_525835_+\|ferredoxin	gnl\|CDD\|224064	COG1141, Fer, Ferredoxin [Energy production and conversion].	4.73558e-09
NZ_CP028497.1\|WP_107906834.1\|526930_528331_+\|glycosyltransferase-family-1-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	8.66885e-67
NZ_CP028497.1\|WP_107906838.1\|531967_533530_+\|VWA-domain-containing-protein	gnl\|CDD\|379243	pfam13531, SBP_bac_11, Bacterial extracellular solute-binding protein. This family includes bacterial extracellular solute-binding proteins.	1.36351e-11
NZ_CP028497.1\|WP_107906833.1\|526102_526720_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380056	pfam17925, TetR_C_20, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the transcriptional regulator KstR that regulates a large set of genes responsible for cholesterol catabolism. This is important for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma.	6.6721e-40
NZ_CP028497.1\|WP_107906845.1\|539083_540037_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	1.24838e-41
NZ_CP028497.1\|WP_107906842.1\|536525_538091_-\|HNH-endonuclease	gnl\|CDD\|379519	pfam14239, RRXRR, RRXRR protein. This domain is found in bacteria, eukaryotes and viruses, and is approximately 180 amino acids in length. It contains a conserved RRXRR motif. It is often found in association with pfam01844.	1.84881e-74
NZ_CP028497.1\|WP_107906849.1\|544385_544928_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	1.44234e-48

>NZ_CP028497.1|WP_107906840.1|534305_535316_-|LLM-class-F420-dependent-oxidoreductase
MRLGLALGYWGRGPSPDHVPLAQEAERLGFDSVWTAESWGSDAFTALTWIAARTSTIRLGTAVAQMAARSPTTTAMHALTLDHLSGGRMMLGLGLSGPQVVEGWYGRPFPKSPLTATREYVDVVRQVLRREGPVALDGRFHSHPYSGPDGTGIGKALKPITHPLRADLPVLLGAEGPKNVAQTIRIADGWLPLYWSPSRPDVYGEAVSDLPEGFLVAPMARVQVCDDVSEGLLPVKAMLGFYIGGMGHAGRNFHADLMARMGYEEEARRIQELFLSGRKEEAVLAVPDAFADEISLVGPRERIAERLELWRKGPVTDLLVLSPDRPTLRLLAELNS
>NZ_CP028497.1|WP_107906839.1|533561_534290_+|hypothetical-protein
MVVWLLTAVCVAVVAQYVVARWVAARRRRRVRDGRMFSGMCIYLHETRVEGVADILGIPKADVNVSHETSVSTGFGLFGRFTVGGRAERDTNTQTRREYWEPNTPMKTIRLIMDRLRARDMVVDADLATGQLFLTAALADELRGAEARGTPLTAVRGTYVSVSGLFTVRRDGEDVVLHARYGTGEPRAQVKITCETSWVREEEFRVDRYSADEEFPATCLGRVRAWNATTGELTLDPISVFQ
>NZ_CP028497.1|WP_107906838.1|531967_533530_+|VWA-domain-containing-protein
MKRRTLTACLTLTLLAALTSCGGGDEDVTLRVLASPELADLEPLLGDLKDDTGVELDMDYRATADLSGARGSSYDLAWPASDRSFLLRLQDKGERAARPESTPIMRSPVVVGLTPRTADTLTARAPDGRLSWADIADAAADGTVRFGMADPRSSDTGRAALVGVATAAAGTGSALREQDVSCDRLRGFRSGQTLTGASSRELIAAYPDHQGEANALIAHESELLSLNASKKLREPLRIVHPDDGMVLSDFPLLLLDADERGAYREVVDWLLKDDVQRELMRRTWRRPVNQDVTPAEPLREAVGNALSYPDRLSIVERLVAYYGDPASATTDQVVFLLDFSGSMRGERIAGLRAAFAGLSGADPTSTGKFARFYRGEHLTVVRFGGRVLQERTVTVRGDGDLRALGKVVAAGSFDDSTAVWSALDRGYRIATDAVREAPERPVAIVLMTDGESNAGISYAEFLRRYERLGADAREVPTFPVHFGEADAAALDKAARATGGRMVDANESSLSDAFKEIRGCH
>NZ_CP028497.1|WP_107907365.1|530702_531971_+|hypothetical-protein
MRTRDRNRPRARLPVHVLLALPLALAGLIALLVTGNALRPFDRVVTIEARMASKSDYFKDPEVQRLLLKHGLRVDIHRLGSRGIATQSLTGMDAVFPSGQPAAKLILDRQDRSVRSVRPFVTPLVLGTFRAYAETLEKMGVATAQPPAGGGRALYYDLDMDRFMDLLDGRTGTKDQAPTGDQDRDGVTERADTWNGIGFDRPGGRSNSGRVLVRTSSVCESNSAGAYLSILAFVANGDSTPGAGQADETKAMEEARTVARKIKPLIDLQGMWADEQADSYLSDLGESIAPISLIYEHQYLAHQIAHEREHGEADTDRVLLYPTPYALTEPQLISLSGEGDRLVRVIQDDPELRRRAIELGFRVRFSGEDGTSDQLNAYLADHGIQVPRPNRDETKVYEPDLDVLEEIIDSVGTCPPAVRDTP
>NZ_CP028497.1|WP_107906837.1|530185_530473_-|hypothetical-protein
MSPRYSSNQAGRVIAIVADVMALILGLWILMYLLDANPANDFVQFVHDAARWLAGWSHDLFTFDEEWARVVAGYGLAAVVYLFVGHAIAGRVHRH
>NZ_CP028497.1|WP_107906836.1|529073_530144_+|prenyltransferase
MTTPRTEHLVLPGVLTAEEAAATVAGILAVQREDGAIPWFRGHHLDPWDHVEAAMALDTAGEHAAAERAYTWLATHQNDDGSWYAAYADGAFDDVTDTGRETNFVAYIAVGVWHHYLSTGDDTFLDRMWPSVHAAIEFVLHLQQPGGQIGWRRDEDGTANPDALLTGSSSIHHALRCALAIAEQREEPQPDWELAAGALRHAIRRHPERFLDKDRYSMDWYYPVLGGALTGAEAKSRMEEGWERFVVPGLGVRCVVPNPWVTGGESAELALALWAMGESDRALDILQSIQHLRDAESGLYWTGYVFEDEAIWPRELTTWTAGSLLLAVAALGGHEATCAVFGGDRLPAGLDPDCCG
>NZ_CP028497.1|WP_107906835.1|528324_529077_+|class-I-SAM-dependent-methyltransferase
MLTVDFSRFPLAPGDRVLDLGCGAGRHAFECYRRGAQVVALDQNGEEIREVAKWFAAMKEAGEAPEGATATAMEGDALALPFPDESFDVVIISEVMEHIPDDKGVLAEMVRVLKPGGRIAITVPRYGPEKVCWALSDEYHEVEGGHIRIYKADELLAKIRGAGLKPYGTHHAHALHSPYWWLKCAFGVDNDKALPVRAYHKLLVWDIMKKPLATRVAEQALNPLIGKSFVAYATKPHLPRLSETSEAAAK
>NZ_CP028497.1|WP_107906834.1|526930_528331_+|glycosyltransferase-family-1-protein
MTAGAREAAASEDLAADGERPLDIALLTYKGNPFCGGQGVYVRHLSRELARLGHRVEVIGSQPYPVLDEGAEYAGRLTLTELPSLDLYRQPDPFRTPGRDEYRDWIDALEVGTMWTGGFPEPLTFSLRARRLLRARSGDFDVVHDNQTLGYGLLGDVGAPLVTTIHHPITVDRQLELDAADGWRRRISVRRWYAFTRMQKRVARRLPSVLTVSGTSRQEIVDHLGVAGDRVHVVHIGADTDLFSPDPSVRRVPGRIVTTSSADVPLKGLVFLVEALAKVRTEHPDAHLVVVGKRPTEGPVAQAVERYGLEGAVEFVKGISDAELVDLVRSAEVACVPSLYEGFSLPAAEAMATGTPLVATTGGAIPEVAGRDGETCLAVPPGDAGALAAGLSRLLGDPELRVRLGSAGRERVLRHFTWARAAEGTVARYREAVARSAGPTPDRSAAPQTFAPKQLAASNPEGRASC
>NZ_CP028497.1|WP_107906833.1|526102_526720_-|TetR/AcrR-family-transcriptional-regulator
MPAEASSASPSSPPLTERQEARRRRILHASAQLASRGGFDAVQMREVAESSQVALGTLYRYFPSKVHLLVATMQDQLEHMHGTLRKKPPQGATAAERVAETLMRAFRALQREPHLADAMVRALTFADRSVSPEVDQVSRQTTVIILDAMGLENPTPEQLSAVRVIEHTWHSALITWLSGRASIAQVKIDIETVCRLIDLTSPEER
>NZ_CP028497.1|WP_107906832.1|525601_525835_+|ferredoxin
MGDRWQVEVDRSVCIGSAQCVHHAPEGFRLDTGRQSHPADPETDANERILAAAESCPVEAIVITLLGSGEPVFPPEE
>NZ_CP028497.1|WP_107906842.1|536525_538091_-|HNH-endonuclease
MTTFSSGEKTHRAVLPQRRALESAGADTPGSRDETACGLPATVPGAGAEHGRGEILSAGSHPAGRRPAPASAGKGETREGHPVVFVLDRHHQPLMPCPPARARKLLSHGRAVVHRHTPFVIRLKDRTAATSEVTGVQLGIDPGSRFTGIALFRAVDEADVSVRHGLFAIELVHRGGPISVRLTSRATLRRARRQRNLRYRAPRFNNRARPEGWLAPSLRHRVDTITAWVNRMTRWAPVRAVHVELSVFDPHAMSAGTSASDAEYRGGTLQGMEVREYLLMKWNRACAYCGATSTPLNIDHIHPRSRGGSDRVSNLTLACLPCNTRKSNMPVEGFLKKKPAVLSKILQQAKTPLRDAAAMNATRCAVLRALEAQHPDVRASTGGRTRWNRRRTATPKSHTLDALCVGVLASVARHPKAIQVVTATGRGTYRRTAPDRYGFPRLHLPRTKQYFGYATGDLVRANVPNGKRQGSHTGRVAVRATGNFNIKTRRGLVQGISQRHVRLLQRADGYAYTTRAEGTHA
>NZ_CP028497.1|WP_107906843.1|538431_538737_-|hypothetical-protein
MTLRIDDTRSTGTVLSKHIDASKGVISAGVGWDVSKSRSITVSGSKEVPRGKHGTLTAFVKYSGKKFDVQAMLVPQGDKWIVQRNKTAYKPIGVCFKYSER
>NZ_CP028497.1|WP_107906844.1|538723_538957_+|hypothetical-protein
MRSVILPRPEAIAMGVFPHLVPMERTWINRLAMIARFPLATSALFALGVACAEVPMPSRLTDKPAMMTPRWAVWKFN
>NZ_CP028497.1|WP_107906845.1|539083_540037_-|N-acetylmuramoyl-L-alanine-amidase
MSYVGPDFDPPQPRRGRRRVLTVGLAALVPGALLGWVMYEAVGGDGGGSGNAAVQPSQAPSDETPTDSTTSDDKPPGPTPTTDSTSAPAGSGSGSLDGKVVVIDPGHNPNNFRHTSEINRKVNIGTNWKECDTTGTSTNDGYSEAEFTLDVAHRMRTLLEKQGATVKFTQDGDRSWGPCVDERAEIGNKAHADAVVSIHADGAGSGQRGFHVILPGKVDEGAANTGPVVAPSRALGERIAGSFVRVTGDAPSNYIGGGTGLVTRKDLGGLNLSTVPKVFIECGNMRDSKDAAQLTSEAWRQKAAQGISEGIMSFLVK
>NZ_CP028497.1|WP_107906846.1|540101_540752_-|class-I-SAM-dependent-methyltransferase
MAPAPKPEILAAFEAAKGFMPTGEGLALHAAAVEAGRLGLPLLEVGTYCGRSTILLADAAREAGVTALTVDHHRGSEEQQPGWEYHDPETVDPAIGLMDTLPTFRRTLHAAGLEEHVIALVGRSPQVAKAWGTPLGLVFIDGGHTDEHANADYEGWAPHVAEGGLLVIHDVFPEPEDEFTGQAPYRVYLRALESGAFTEVSVTDSLRVLKRTGTGI
>NZ_CP028497.1|WP_107906847.1|540875_542636_-|MFS-transporter
MTRTTNEQPIGRADTGTPGPSGALVPVLAFAGIVVAVMQTLLVPVIKDLPQLLGTEPSNATWVLTSTLLSGAVATPIMGRLGDLYGKRRMLIASLSVMVVGALISAFTSALLPMIVGRTLQGFAMGAIPLGIGLMRDMLPREKLGSAMALMSSSIGVGGGLALPAAALVAQHSNWHALFYGAAGLGVLSIALTLLVVPESKVRAEGTFDGLGALGLSVGLVLFLLPITKGSDWGWTSATTLGMFAGSAAVLLLWGVYELRSKAPLVDLRTTARPAVLFTNLASIMVGVSFYVVSLVLPQLLQLPKATGYGLGQSMVVAGLLVAPLGLTMMFTAPVYARLSAKYGPKTTLILGMLIIAIGYGAGLGLMSAAWQSLVIAVVLGAGIGLAYSSLPALIIGAVPASETGAANGLNTLMRSIGTSVSSAVIGMVLANTANNVGGVAIPTMHGFRVSFLIATAAVAVGLLLALFLPKQRPAAHTQLRASSEEDANLERAEEALRGFRGRVLDAGGTPVARAKVTLIDRRGRQAGATLSADDGSYALAVPAQGAYVLAARADGHAPLASSATHTGDDSPVDLDLSLPGETVTA
>NZ_CP028497.1|WP_107906848.1|542848_544321_+|MFS-transporter
MTPMFDAADVTRAPRRSAPPTWLVVALACAGQFLVVLDVAVVNVALPSMRADLGLDAQGLQWVVNAYAIAFAGFMLLGGRAGDLYGRKRMFLVGLGLFTLASLAGGLAQQDWQLLAARGVQGLGAAVLAPSTLTIVTAAVPEGAARARAIGTWTAVGAGGGAAGGLVGGVLVDLLSWRWVLLINVPVGAVVLGGAVLWLAESRAGEGRRLDLPGAVLVTAGLATLAFGISQTEAAGWTAPDTVVPLLAGLALIGAFLAVEARTAAPLMPLGLLRVRAVASANAAMFLCGSAMFCMWFFMTLYAQNVLHYTPLEAGLALAPSSLAVVLGSKLAPRLMRGAGPRAVAVAGTLVAAVGFGWQSMLSVDGGYITSIMMPGILMMLGAGLATPPLASLAMSGARPEEAGLVSGLVNTSRTMGGSLGLAVMSTIAAARSEGSGAPGALTEGYALVFRTSTVVLLVGAVLMLVWLPRKTAAASPQPSSVTSSTSSAN
>NZ_CP028497.1|WP_107906849.1|544385_544928_+|SigE-family-RNA-polymerase-sigma-factor
MGDRKAARDSEFQSFVIGRWPRLLRTAFLLTGEQHAAEDLVQSTLEQVYVAWRRVGSADDPEAYVRRVMINAHARKHRRRLREFLAPKDDSGLAREVPDTGDRIAQAEDRDALLSALAQLPPRQREAVVLRYWEDLTETQTAEAMGCSVGAVKSNAAKGIAKLRAIPGLAEMVTQGGRSR
>NZ_CP028497.1|WP_107906850.1|544924_545764_+|hypothetical-protein
MSADRETNHGMTSHDMTHTDIALLLADAADEVEIGIAPYDAVLRGGRRRRARRWAVATATALVLVGSAGTLAVAGIPGGDGDRGATLATSPPTEPAPDVRTPARTLLALGTDAGKDWRVYLDVWEAPRNEREAREERGAMAEFGHIPSDLRDASDLIGRNSYFVRREYGDATSDQVLIEDTFTAEDNMSGKDIEAVSVPLEPGSGSGPERLVVGQVAVTARSVTCTWQDGSKTEVPVVSEAGDYNSDDFVIRPADGSPVNWFVCLAPKGTEYKSVAVTR
>NZ_CP028497.1|WP_107907366.1|545821_546454_-|DNA-binding-response-regulator
MPRDHRPTKSIRVLLAEDQGMMRGALALLLGMEPDITVVAQVSAGDTIVDAALTHRPDVALLDIELPGLSGLDAAAELRDQVPDCRVLILTTFGRPGYLRRAMEAGAAGFLVKDGPVEELAVAVRRVLTGETVIDPALAAAALSAGPNPLTARERDVLNASTEGATVADIAGKLHLSESTVRNYLSSAIGKTGTRNRMEALREARQQGWL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage