CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP021257	Legionella pneumophila subsp. fraseri strain Lansing 3 chromosome, complete genome	4 crisprs	cas2,cas1,cas9,RT,WYL,cas3,PD-DExK,DinG,DEDDh,csa3	0	2	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021257_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021257_1

206564-207540

TypeII

Consensus_repeat	Method
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CRISPRCasFinder
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CRT
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	PILER-CR

13 spacers

cas4,cas2,cas1,cas9

The CRISPR arrays of NZ_CP021257_1

>merge|NZ_CP021257|1|206564-207540|CRISPRCasFinder,CRT,PILER-CR
ATTTCATTAGTTAAATTTTTAGATGGGGGATTTTTGGAAGAAGTCAGGCTACGACCATGAAAACGATGCGACGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTAAAGATGTGACGCTGTACCCTGGGGAATGTCAAAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGGTCTTGAGTGGGGTATTGACGTTCGCACTTACGAACGAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGGAAAAAGGAAAACATGAGATAGGGCAAGTCTACGAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGAAGATTTTCCGCACCCAGGGCCACCGACAAAAAGGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCAGACACAGCTAAATGCAAAAGAGTCTACGGCTGTTACGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGAAGCGAGCAGAGACAAGCTCTTAAAATCGAAAGAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCTTACATACCCGCACACGCTAATTGTCGTTGTACGGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTCAAGTTGAAAATGCCAAAGAAGCCTTAAAAGACGGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGATTGATTATCTCTTCGGCCTTATACGGGTAAATTCGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGAAATAAGCATTTCACAAGCTCAAAGAATTGAAAGCGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTCTAACACAGGTACGTATCTTGGCACTAGTCGCGGGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTATTATGCATATAGTAAATAATTAACTGATATAAAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

>NZ_CP021257|1|1|206564-207540|CRISPRCasFinder
ATTTCATTAGTTAAATTTTTAGATGGGGGATTTTTGG	AAGAAGTCAGGCTACGACCATGAAAACGATGCGAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TAAAGATGTGACGCTGTACCCTGGGGAATGTCAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	GTCTTGAGTGGGGTATTGACGTTCGCACTTACGAACGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	GAAAAAGGAAAACATGAGATAGGGCAAGTCTACGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGATTTTCCGCACCCAGGGCCACCGACAAAAAG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CAGACACAGCTAAATGCAAAAGAGTCTACGGCTGTTAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGCGAGCAGAGACAAGCTCTTAAAATCGAAAGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CTTACATACCCGCACACGCTAATTGTCGTTGTACG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCAAGTTGAAAATGCCAAAGAAGCCTTAAAAGACG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	ATTGATTATCTCTTCGGCCTTATACGGGTAAATTC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAATAAGCATTTCACAAGCTCAAAGAATTGAAAGC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCTAACACAGGTACGTATCTTGGCACTAGTCGCGG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TATTATGCATATAGTAAATAATTAACTGATATAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

>NZ_CP021257|1|1|206564-207540|CRT
ATTTCATTAGTTAAATTTTTAGATGGGGGATTTTTGG	AAGAAGTCAGGCTACGACCATGAAAACGATGCGAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TAAAGATGTGACGCTGTACCCTGGGGAATGTCAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	GTCTTGAGTGGGGTATTGACGTTCGCACTTACGAACGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	GAAAAAGGAAAACATGAGATAGGGCAAGTCTACGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGATTTTCCGCACCCAGGGCCACCGACAAAAAG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CAGACACAGCTAAATGCAAAAGAGTCTACGGCTGTTAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGCGAGCAGAGACAAGCTCTTAAAATCGAAAGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CTTACATACCCGCACACGCTAATTGTCGTTGTACG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCAAGTTGAAAATGCCAAAGAAGCCTTAAAAGACG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	ATTGATTATCTCTTCGGCCTTATACGGGTAAATTC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAATAAGCATTTCACAAGCTCAAAGAATTGAAAGC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCTAACACAGGTACGTATCTTGGCACTAGTCGCGG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TATTATGCATATAGTAAATAATTAACTGATATAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

>NZ_CP021257|1|1|206636-207540|PILER-CR
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TAAAGATGTGACGCTGTACCCTGGGGAATGTCAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	GTCTTGAGTGGGGTATTGACGTTCGCACTTACGAACGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	GAAAAAGGAAAACATGAGATAGGGCAAGTCTACGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGATTTTCCGCACCCAGGGCCACCGACAAAAAG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CAGACACAGCTAAATGCAAAAGAGTCTACGGCTGTTAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGCGAGCAGAGACAAGCTCTTAAAATCGAAAGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CTTACATACCCGCACACGCTAATTGTCGTTGTACG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCAAGTTGAAAATGCCAAAGAAGCCTTAAAAGACG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	ATTGATTATCTCTTCGGCCTTATACGGGTAAATTC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAATAAGCATTTCACAAGCTCAAAGAATTGAAAGC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCTAACACAGGTACGTATCTTGGCACTAGTCGCGG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TATTATGCATATAGTAAATAATTAACTGATATAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021257.1\|WP_027228130.1\|208635_209628_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NZ_CP021257.1\|WP_032832055.1\|208329_208629_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_CP021257.1\|WP_027228132.1\|213914_214133_-\|AlpA-family-phage-regulatory-protein	unknown	unknown	gnl\|CDD\|225848
NZ_CP021257.1\|WP_028378717.1\|203394_203676_-\|VirB3-family-type-IV-secretion-system-protein	unknown	unknown	gnl\|CDD\|368285
NZ_CP021257.1\|WP_027228128.1\|205549_206215_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224885
NZ_CP021257.1\|WP_028378712.1\|209624_213743_-\|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12	cas9	cd09704_cas9_CAS-II-B	gnl\|CDD\|187835
NZ_CP021257.1\|WP_106331205.1\|216486_218001_+\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP021257.1\|WP_028378713.1\|204516_205386_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_050598121.1\|214593_214926_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_027228134.1\|214915_215866_+\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NZ_CP021257.1\|WP_028378718.1\|200927_203408_-\|VirB4-family-type-IV-secretion/conjugal-transfer-ATPase	unknown	unknown	gnl\|CDD\|273346
NZ_CP021257.1\|WP_027228129.1\|207755_208349_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NZ_CP021257.1\|WP_028378720.1\|199667_200063_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_028378715.1\|203972_204176_-\|carbon-storage-regulator	unknown	unknown	gnl\|CDD\|376847
NZ_CP021257.1\|WP_028378719.1\|200220_200931_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271354
NZ_CP021257.1\|WP_028378828.1\|218012_218759_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|366760
NZ_CP021257.1\|WP_080274090.1\|200059_200206_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_028378716.1\|203685_203976_-\|TrbC/VirB2-family-protein	unknown	unknown	gnl\|CDD\|368210
NZ_CP021257.1\|WP_028378714.1\|204188_204551_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_161499081.1\|216098_216440_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP021257.1\|WP_027228130.1\|208635_209628_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	8.09137e-79
NZ_CP021257.1\|WP_028378712.1\|209624_213743_-\|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12	gnl\|CDD\|187835	cd09704, Csx12, CRISPR/Cas system-associated protein Cas9. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II.	0
NZ_CP021257.1\|WP_027228132.1\|213914_214133_-\|AlpA-family-phage-regulatory-protein	gnl\|CDD\|225848	COG3311, AlpA, Predicted transcriptional regulator [Transcription].	1.23875e-05
NZ_CP021257.1\|WP_027228128.1\|205549_206215_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224885	COG1974, LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms].	1.51213e-17
NZ_CP021257.1\|WP_028378717.1\|203394_203676_-\|VirB3-family-type-IV-secretion-system-protein	gnl\|CDD\|368285	pfam05101, VirB3, Type IV secretory pathway, VirB3-like protein. This family includes the Type IV secretory pathway VirB3 protein, that is found associated with bacterial inner and outer membranes. The family also includes the conjugal transfer protein TrbD family that contains a nucleotide binding motif and may provide energy for the export of DNA or the export of other Trb proteins.	9.39624e-19
NZ_CP021257.1\|WP_106331205.1\|216486_218001_+\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	3.17347e-35
NZ_CP021257.1\|WP_032832055.1\|208329_208629_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.27967e-05
NZ_CP021257.1\|WP_027228134.1\|214915_215866_+\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	1.72252e-20
NZ_CP021257.1\|WP_028378718.1\|200927_203408_-\|VirB4-family-type-IV-secretion/conjugal-transfer-ATPase	gnl\|CDD\|273346	TIGR00929, CAG_pathogenicity_island_protein_23, type IV secretion/conjugal transfer ATPase, VirB4 family. Type IV secretion systems are found in Gram-negative pathogens. They export proteins, DNA, or complexes in different systems and are related to plasmid conjugation systems. This model represents related ATPases that include VirB4 in Agrobacterium tumefaciens (DNA export) CagE in Helicobacter pylori (protein export) and plasmid TraB (conjugation).	0
NZ_CP021257.1\|WP_027228129.1\|207755_208349_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	4.12817e-15
NZ_CP021257.1\|WP_028378715.1\|203972_204176_-\|carbon-storage-regulator	gnl\|CDD\|376847	pfam02599, CsrA, Global regulator protein family. This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay. In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes. RmsA binds to RmsB regulatory RNA.	4.27589e-15
NZ_CP021257.1\|WP_028378719.1\|200220_200931_-\|hypothetical-protein	gnl\|CDD\|271354	cd14262, VirB5_like, VirB5 protein family. This family contains VirB5 domains, including TraC, a VirB5 homolog encoded by the pKM101 plasmid, and similar proteins. VirB5 is one of 11 conserved proteins (VirB1-VirB11) in Agrobacterium tumefaciens, the causative agent of crown gall disease, that span the inner and the outer membrane, and is involved in type IV DNA secretion systems (T4SS) which mediate the translocation of virulence factors (proteins and/or DNA) from Gram-negative bacteria into eukaryotic cells. VirB5 assembles extracellular pili by interacting with several essential proteins. VirB2-VirB5 complex formation precedes incorporation into pili; it depends on the inner membrane protein VirB4 to interact directly with and stabilize VirB8 in order for VirB5 to bind to VirB8 and VirB10. Mutagenesis studies show that VirB5 proteins participate in protein-protein interactions important for pilus assembly and function.	1.7025e-17
NZ_CP021257.1\|WP_028378828.1\|218012_218759_+\|ATP-binding-protein	gnl\|CDD\|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	2.54556e-68
NZ_CP021257.1\|WP_028378716.1\|203685_203976_-\|TrbC/VirB2-family-protein	gnl\|CDD\|368210	pfam04956, TrbC, TrbC/VIRB2 family. Conjugal transfer protein, TrbC has been identified as a subunit of the pilus precursor in bacteria. The protein undergoes three processing steps before gaining its mature cyclic structure. This family also contains several VIRB2 type IV secretion proteins. The virB2 gene encodes a putative type IV secretion system and is known to be a pathogenicity factor in Bartonella species.	2.11384e-12

>NZ_CP021257.1|WP_027228128.1|205549_206215_+|helix-turn-helix-domain-containing-protein
MNIKKEIGKRILEARKAKGLTLKALGELAGGLKQTRLTNWEQGVRTPGPEEIKSLAQALDVSPAYLMCLSDEKRFKEVQSPSQLVPLLTHYQACEALLHIQTIREQENPNNITLISVSMALLPVLSADAFALKMLDDSMIPEIRINDIQVIDPNAQPNPGDYVAVKVRGKEEAIICVYKKLSYTSSQFELLTLNDNWPDIKVSDIAEVNILGKLVLNIRTY
>NZ_CP021257.1|WP_028378713.1|204516_205386_-|hypothetical-protein
MMDFVINGDELEAMCGLPHIQQLTYLRGIRPYMDVKTGIVGIKRRISHQSISEQLYVEPHQGIKNQSFSRDQVRRAVSGLVRAGLIEVQSEGMHLILKCLLASQHYSVQNKAAINPPQKATIKPREESLENTGLSEVEALKADTVEPPKAAIPHKDNYYIYLLSQFEKFWSLYPEKKSRNNAQAVFEELNPDAELFHTIINALNAQINHRETMKLQGTWVPPWKYPANWLAQRCWEDELPTDALQEKHHAEHTKNTRKRHTTEDLFCPPCDVEERGNNNVIQLQRYLQS
>NZ_CP021257.1|WP_028378714.1|204188_204551_-|hypothetical-protein
MSSSSKDTFKAERRIDLLFSKFAAFYGHVWRSQFKDEVFLRFAKKEWQEALADFTDAVLAKAILNCREFYELPPTLPQMLYCCRQIRKQVTFYVIKDEYQPANKAVVSSCLQKCKELLAK
>NZ_CP021257.1|WP_028378715.1|203972_204176_-|carbon-storage-regulator
MLVLTRKAGQQILIGKGLIQMKVLKVDDDIISIGIKAPQHIDIDREEIYLKKLQKEQAESSLQKVAL
>NZ_CP021257.1|WP_028378716.1|203685_203976_-|TrbC/VirB2-family-protein
MSKFNRLSQSISDLYLVAVCTLLPSLSHAQSIESIINRTINYLQGGLARTVGVFCIIIAGYLCLARQKFPKEYFVMILVGMGIIFGGSSLYSTLIG
>NZ_CP021257.1|WP_028378717.1|203394_203676_-|VirB3-family-type-IV-secretion-system-protein
MSDLEISPIFNALTRPAMIAGVTFEYHMLNLIVSMCVFIGLSPLYGLIFIPLHVFGWLVCRYDTHFFTICAKRYLLPEAPNASIWRVRAYEPF
>NZ_CP021257.1|WP_028378718.1|200927_203408_-|VirB4-family-type-IV-secretion/conjugal-transfer-ATPase
MNLSKTLKQVYQEAKVSDLFPITHLNTPSIFESQSGFVGSVLKVDGAAFEIEEADTLNHQRFLLHQALVSLDSRFIIYVTTHRQKISCPLIGEFKPGFAKDLDERYQQRFTDKNLYKNTLYITVILKGDDSGKTGSWLQWAKRFSIQGNSELAEHHREQNIQTLNRAVEQLQANLAPFRASLLGQQDDALGFSELLQFLGLVVNAGHPALFKHPFYSPPIANSIPNTFKHETRYPEGHIGQYLSGCQILFGECIQFQGNTQDDCLFGAMLSLKKYPTHTASILLDSLLSLDCEFIATHSFAPIGRDSALDTISKKRSKLLNAEDKALSQTSALTDLEDGIASETLLLGAHHHTLMLLAPSKSLLDAAILEATKRYGSAGIVVVKETLGQEPAFWSQLPCNQHFITRASLITSQNFVDFCPLHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTLVNFLDAQMGRFGGRSFFIDRDESSKIYVLASGNSSYIKVEPSNPIAMNPLQLPDTAENRSFLKSWFATLVQEEGERVIPSDIAEIINDCIDYNFEQLAPEFRTLSYLSQFLPVDFPRWPHLRRWLKRNDSRIDGEFHWLFDNPNDALNLDFDKVGFDVTYLMDQVQSIIATPVYLYLLHRMRQCLDGRLTSFIIAEAWQLFASPFWEKCLKEWLPTIRKKNGHFIFDTQSPKTITDSPIKHIVLDNLATLIAFPNPLADRETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHEAFLCKLDLSGLSQYIRVLSANTQSVKLLDEIIEEVGQEPELWLPVFFERSNK
>NZ_CP021257.1|WP_028378719.1|200220_200931_-|hypothetical-protein
MKRTACFLIAALSLSSVSHADILGVEDAQLILLAMKQLSELQEQYRVLSDTYQTAKNQLDNLNQLKSMNSGHYGFGDINNSLDSLQSWQSPVSTWQDALQNLSGGNQQRYQALVDAYEKNHPALDEASYSRFTTPANAMRFKEDKAVNRAVMVQTTESYNEINKHMEALHKLSQQIEKTPNTKGAIDLNSRLITEIGFIQLMSLRLQALISQQSAQENLSALQDRAEMAKFNRLPK
>NZ_CP021257.1|WP_080274090.1|200059_200206_-|hypothetical-protein
MKWLLSVLMMVVLSGCSKPPDLDSPCHHFGQYCPQYPINDEPIMELTK
>NZ_CP021257.1|WP_028378720.1|199667_200063_-|hypothetical-protein
MNHLLKSLMVVLMAAAISACQHENPLKTQPAKTSVTFLINASANAEKRLHFAIHKDAYGFAYLECMEGKQSPEIRCDALYQGMIAFAKEGHYSGFQKITLADLTDKNLFESLADEYAETAATTWPHLVSGT
>NZ_CP021257.1|WP_027228129.1|207755_208349_-|CRISPR-associated-protein-Cas4
MDTSSYKLPVNMIRQYCFCPRIVYYHMVIGLKVAYPGWVQYGEEYQHKQQILDKRRTLSKFKPISEQAILRQNTMLEHPSYPFYGICDGIIEDELEIIPIELKSFASKISLGQKMQLTAYGMLSELIFEKSCTRGYIITGEKAKAKLIKIDEKSKFKVLEIYAKIKKIFDTETLPYSTANGLQCIQCEFLNHCNDRF
>NZ_CP021257.1|WP_032832055.1|208329_208629_-|CRISPR-associated-endonuclease-Cas2
MQTRLYKEYIVSYDIRDNSIRRTIYERLKDIGLTPVQKSVFWGYLNEPEKRYLTNVLKKELAKQDTAFITPCKLAQEYEVNLINLELDELRKPDGHIIV
>NZ_CP021257.1|WP_027228130.1|208635_209628_-|CRISPR-associated-endonuclease-Cas1
MKHLTLSEQGSSCKLQGERILVFNKDHMVFEGTLNRLKTISIAKQGVTLTSNLLVACAMRGIQIFILDYSGKAVCSLQGGLHRTAKVRENQFKYIYTKEASNMAARFILAKIKNQSAVLKYFAKAKNRPENEKIILHTASQKIAGIVSNITETNWIKLQDWRFTLLGFEGSAAKIYWETVKEVNLVCSDFEGRRPRVNKDITNSMLNYAYSILSSWVWQAITNAGLELYAGILHTSKPGKPSLVLDLMEEFRPWCADRIIFKLRARAQKQNELTPALKKALIDEMANLYAKPLPYHKRRISLESIIQRQVYHLSAVFSGEGKYKGYLFKW
>NZ_CP021257.1|WP_028378712.1|209624_213743_-|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12
MESSQLLSPIGIDLGGKFTGVCLSHLESFAELPNHANTKYSVILMDHNNFQLSQAQRRITRHRVRNKKRNQFVKRVALQLFQHMLSRELNVKEEIALCHYLNNRGYTYVDTDLDEYLKDETTVNLLKELLPPESEHNFIDWLLQKMQSSKFREILGSRVEEKKDDKELKNAVKNIKNFITGFEKNSVEGHRHRKVYFENIKSDITNDNQLDGIKKKIPSVCLSNLLGHLSNLQWKNLHRYLAKNPKQFDEQTFGNEFLRMLKNFKHLKGSQESLAVRDLIQQLEQSKDYISILEKTPPEITIPPYEARTNTGMEKDQSLLLNPEKLNNLYPKWRNLIPGIIDAHPFLEKDLEHTKLRDRKRIISPSKQDEKRDSYILQRYLDLNKKIDKFKIKKQLSFLGQGKQLPANLIETHKEMETHFSSSLVSALIQIASAYNKEREDAAQGIWFDNAFSLCELSNINPPRKQKILPLLVGAILSEDFINNKDKWAKFKSFWNTHKIGRTLLKYKCKEIEEARKNSGNAFKIDYEEALNHPEHSNNKALTKIIQTIPDIIQAIQSHLGHNDSQALIYNNPFSLSQLYTILETKRDGFHKNCVAVTCENYWRSQKTEIDPEISYASRLPADSVRPFDGVLARMMQRLAYEIAMAKWEQIKHIPDNSSLLIPIYLEQNRFEFEESFKKIKGISRDKTLEQAIEKQNIRWEEKFQRIINASMNVCPYKGTLIGGQGEIDHIYPRSLSKKHFGTIFNSEANLIYCSSQGNREKKEEHYLLEHLSPIYLKHQFGTDNVSDIKNFISQNVANIKKYISFHLLTPEQQKAARHALFLDYDDEAFKTVTKFLMSQQKARVNGTQKFLGKQIMEFLSTLADSKQLQLEFSIKQINAEEVHNHRELLSKQEPKLAKSQQQSFPSHAIDATLTMGIGLKEFPQFSQELDNSWFINHLMPDEVHLNPVQSKEKYNKPNISSIPLFKDSLYAERFIPVWVKGETFAIGFSEKDLFEIKPSNKEKLFTLLKTYSTKNPGESLQELQAISKAKWLYFPINKTLALEFLHHYFHKETVTPDDTTVCHFINSLRYYTKKESITVKILKESMPVLSVRFESSKKNVLGTFKHTIALPATKDWERLFNHPNFLALKANPNPNPKEFNEFIKKYFLSENNPNSDIPNNDHTIKPQKHKTVRKVFSLPVIPGNAGTMMRIRRKDNKGQPLYQLQTIDDTPSMGIQINEGKLVKQEVLMDAYKTRNLSTIDGINNSERQAYAAFDNWLTLPVSTFKPEIIKLEMKPHSKTRRYIRITQSLADFIKTIDEALMIKPSDSIDDPLNMPNEIVCKNKLFGNELKPRDGKMKIVSTGKTVTYEFESDSTPQWIQKLYVTQLKKHP
>NZ_CP021257.1|WP_027228132.1|213914_214133_-|AlpA-family-phage-regulatory-protein
MTKLPEIGFLRANQIIGDKNANPPIPALIPIGKSTWWAGVKSGRFPKPIKFGSRITVWRVEDIREFIEKASL
>NZ_CP021257.1|WP_050598121.1|214593_214926_+|hypothetical-protein
MASPRQISRCFADLVEMGKLVKIGYGIYAKAYRSEYLNKPVIKGGFSQICKEALTKLGVEWIPGSAEQAYNSGLSTQVPVRTIVQLKSRFRGHLKYGNRQLVVEKGINAR
>NZ_CP021257.1|WP_027228134.1|214915_215866_+|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MLGKPLLELITTTGEILELEDLVIEKDYYVAQVINALSKVENDYFRLVFCGGTCLAKAHKVIYRMSEDIDFKIQIKEIDEHLSKTRLLKELKIFRSLIQSKLTHLDLSIGNTVVRNEGQYSRIELDYPSVFPFNSRLRPHILLEFTLSNIRLATSSLPIKTLIEETLENIILFAPCFTHCISVNETAIEKWAGLTRRVVAIERNYHPDDETLIRHVYDLNAIKQASKIDENFFTLAKTIVSNDAKQFKNQHPEYADNPSEEIKQSLSLLKNKLIWKARYQEFIETMVYDNINTIDYETAIANIEHISTKIMGFLSE
>NZ_CP021257.1|WP_161499081.1|216098_216440_-|hypothetical-protein
MYKNCLIVSVGGDQIRPESLIKCSGIGDQVTSESLIKCFRNQRSNAAGIGDHFAPEYTVENKNALQYGVFTPKAFKFFGQILGTFSKILGTFWVIFEPTENHKRQPYQPENWI
>NZ_CP021257.1|WP_106331205.1|216486_218001_+|IS21-family-transposase
MRKIQEVFRQHEQGHSNRDIGRSLNISSGTVSNYLYRARVAGLTLAETLSLGEQQLYERLFLPSKASSTRRVLPDWECIHAELRKKGMTLMLLWREYRECHPDGVGYSQFCDRYKRYVKQISPVMRQVHKAGEKVFVDYAGMTVPWIEPSTGEIHEAQVFVASLGASQFTFVDITESQSLEHWITSHIRMWNYFGGVTKIVVPDNLKSGVSKSHRYDPDINANYQHVSEHYGVAIVPARAAEPKDKAKVENAVGCIERQILAPLRHHTFTSIAEIKKAIAPKLVAFNKQSFQKMNTSRLELFEALDKPALQPLPSEPYHYAEWKRAKVNIDYHFVFDEHYYSVPYQYIHKTIEVRTSGSMVECFHEGKRIALHTRSKKRFTHTTLAEHMPSSHKAHAEWTPERIHRWALKTGEDTVRYIEYMIAARAFPEQAFRSCLGLMRLAQRFGADRLENACAIALEAGMTRYQQVERLLKNNMDLVRTSSKTTTPVIPHHNNLRGSNYYQ
>NZ_CP021257.1|WP_028378828.1|218012_218759_+|ATP-binding-protein
MLNNPTLDKLRSLKLTGMADEFTEQLKRPVNDLDFEERLGLLVEREYLLRDNRKMERRLKQAKLQLNACMEDIDFKHPRGLNKSAMLELFRCQWVSQHLNLLITGPTGCGKTYIACALAHKACITGFSSRYYRLPRLWNELKIAKANGSYPNWLASIAKVDVLVLDDWGLVAPDEEQRRDLLEILEDRYQKRSTIITSQLAVALWHEHLGDATLADAVLDRLVHNSIRIELNGESMRKTKKSLQTKPL

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Crispr_ID: NZ_CP021257_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021257_2

628265-628437

Orphan

Consensus_repeat	Method
AAATTACTGTTATGGCGGTAAATTTACTCGA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP021257_2

>merge|NZ_CP021257|2|628265-628437|CRISPRCasFinder
ATATTACTGTTATAGCAGTAAAAATGATTAAAATAAATTTATTATTGCATTTTTTTGCATTAATTCACCATAAATTACTGTTATGGCGGTAAATTTACTCGATTTTCTAATTTTCTGTGTATTTATTTATGTTAAATTTATAAAATTACTGTTATGGCGGTAAATTTATTCGA

>NZ_CP021257|2|2|628265-628437|CRISPRCasFinder
ATATTACTGTTATAGCAGTAAAAATGATTAA	AATAAATTTATTATTGCATTTTTTTGCATTAATTCACCAT
AAATTACTGTTATGGCGGTAAATTTACTCGA	TTTTCTAATTTTCTGTGTATTTATTTATGTTAAATTTATA
AAATTACTGTTATGGCGGTAAATTTATTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021257.1\|WP_032832101.1\|636693_637914_-\|type-II-toxin-antitoxin-system-HipA-family-toxin	unknown	unknown	gnl\|CDD\|341492
NZ_CP021257.1\|WP_011214444.1\|623847_624015_+\|DUF3309-domain-containing-protein	unknown	unknown	gnl\|CDD\|378708
NZ_CP021257.1\|WP_027227422.1\|621882_622524_+\|RsmD-family-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|370496
NZ_CP021257.1\|WP_031301595.1\|630570_630819_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180883
NZ_CP021257.1\|WP_027227415.1\|628015_628243_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|213767
NZ_CP021257.1\|WP_028378585.1\|625318_626482_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_028378828.1\|632036_632783_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|366760
NZ_CP021257.1\|WP_063720028.1\|622892_623249_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_027227407.1\|637900_638128_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|213767
NZ_CP021257.1\|WP_027227423.1\|620436_621339_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_027227417.1\|626775_627714_-\|lpg2370-family-Dot/Icm-T4SS-effector	unknown	unknown	gnl\|CDD\|377920
NZ_CP021257.1\|WP_027227408.1\|636302_636659_+\|preprotein-translocase	unknown	unknown	gnl\|CDD\|271182
NZ_CP021257.1\|WP_106331205.1\|632794_634309_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP021257.1\|WP_027227419.1\|624139_625327_+\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|224316
NZ_CP021257.1\|WP_027227409.1\|635357_636263_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP021257.1\|WP_027227414.1\|628683_629601_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176109
NZ_CP021257.1\|WP_027227411.1\|630834_631146_+\|cupin	unknown	unknown	gnl\|CDD\|380355
NZ_CP021257.1\|WP_027227416.1\|627710_628019_-\|HipA-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|274416
NZ_CP021257.1\|WP_027227413.1\|629790_630264_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_027227424.1\|618820_620275_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP021257.1\|WP_032832101.1\|636693_637914_-\|type-II-toxin-antitoxin-system-HipA-family-toxin	gnl\|CDD\|341492	cd17793, HipA, type II toxin-antitoxin sytem toxin HipA and similar proteins. This family contains type II toxin-antitoxin (TA) system HipA family toxins similar to Escherichia coli and Shewanella oneidensis HipA, which is a serine/threonine-protein kinase that phosphorylates Glu-tRNA-ligase (GltX), preventing it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. HipA is the toxin component of the HipA-HipB TA module that is a major factor in persistence and bioflim formation; its toxic effect is neutralized by its cognate antitoxin HipB. HipA, with HipB, acts as a a corepressor for transcription of the hipBA promoter. Structures of HipAB:DNA complexes from both Escherichia coli and Shewanella oneidensis reveal distinct complex assembly.	6.24156e-164
NZ_CP021257.1\|WP_011214444.1\|623847_624015_+\|DUF3309-domain-containing-protein	gnl\|CDD\|378708	pfam11752, DUF3309, Protein of unknown function (DUF3309). This family is conserved in bacteria but its function is not known.	1.02464e-06
NZ_CP021257.1\|WP_027227422.1\|621882_622524_+\|RsmD-family-RNA-methyltransferase	gnl\|CDD\|370496	pfam09445, Methyltransf_15, RNA cap guanine-N2 methyltransferase. RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.	4.41586e-28
NZ_CP021257.1\|WP_031301595.1\|630570_630819_+\|hypothetical-protein	gnl\|CDD\|180883	PRK07206, PRK07206, hypothetical protein; Provisional.	4.2641e-28
NZ_CP021257.1\|WP_027227415.1\|628015_628243_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	3.72777e-23
NZ_CP021257.1\|WP_028378828.1\|632036_632783_-\|ATP-binding-protein	gnl\|CDD\|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	2.54556e-68
NZ_CP021257.1\|WP_027227417.1\|626775_627714_-\|lpg2370-family-Dot/Icm-T4SS-effector	gnl\|CDD\|377920	pfam07804, HipA_C, HipA-like C-terminal domain. The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.	1.15502e-59
NZ_CP021257.1\|WP_106331205.1\|632794_634309_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	3.17347e-35
NZ_CP021257.1\|WP_027227419.1\|624139_625327_+\|fatty-acid-desaturase	gnl\|CDD\|224316	COG1398, OLE1, Fatty-acid desaturase [Lipid metabolism].	9.99483e-86
NZ_CP021257.1\|WP_027227409.1\|635357_636263_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.11546e-52
NZ_CP021257.1\|WP_027227414.1\|628683_629601_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176109	cd08417, PBP2_Nitroaromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of dinitrotoluene and similar compounds, such as DntR, NahR, and LinR. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. Also included are related LysR-type regulators clustered together in phylogenetic trees, including NodD, ToxR, LeuO, SyrM, TdcA, and PnbR. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.49817e-54
NZ_CP021257.1\|WP_027227411.1\|630834_631146_+\|cupin	gnl\|CDD\|380355	cd02226, cupin_YdbB-like, Bacillus subtilis YdbB and related proteins, cupin domain. This family includes bacterial proteins homologous to YdbB, a Bacillus subtilis protein of unknown function. It also includes protein Nmb1881 From Neisseria meningitidis, also of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.62088e-10
NZ_CP021257.1\|WP_027227408.1\|636302_636659_+\|preprotein-translocase	gnl\|CDD\|271182	cd00801, INT_P4_C, Bacteriophage P4 integrase, C-terminal catalytic domain. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. The P4 integrase mediates integrative and excisive site-specific recombination between two sites, called attachment sites, located on the phage genome and the bacterial chromosome. The phage attachment site is often found adjacent to the integrase gene, while the host attachment sites are typically situated near tRNA genes. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.84214e-13
NZ_CP021257.1\|WP_027227407.1\|637900_638128_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	2.73488e-18
NZ_CP021257.1\|WP_027227416.1\|627710_628019_-\|HipA-N-terminal-domain-containing-protein	gnl\|CDD\|274416	TIGR03071, couple_hipA, HipA N-terminal domain. Although Pfam models pfam07805 and pfam07804 currently are called HipA-like N-terminal domain and HipA-like C-terminal domain, respectively, those models hit the central and C-terminal regions of E. coli HipA but not the N-terminal region. This model hits the N-terminal region of HipA and its homologs, and also identifies proteins that lack match regions for pfam07804 and pfam07805.	2.48908e-43

>NZ_CP021257.1|WP_027227415.1|628015_628243_-|helix-turn-helix-transcriptional-regulator
MRTHEIANLVHYYRKQSGLSQQELARLAGVGKTVIYDIEKGKESVRLNTLLKVLDVLNIQMKFETPFPQTTDNNS
>NZ_CP021257.1|WP_027227416.1|627710_628019_-|HipA-N-terminal-domain-containing-protein
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYQGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRNDYFGQLVIVGQDVVGAVTIEELR
>NZ_CP021257.1|WP_027227417.1|626775_627714_-|lpg2370-family-Dot/Icm-T4SS-effector
MKRCPITYERISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNGHYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNRKLALEDFAQLSGEDRHTKYKSSMEKVIAVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALSLKGKKNNLTKSDFLKYFAIEKLGLNQKVIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKRLNFFD
>NZ_CP021257.1|WP_028378585.1|625318_626482_-|hypothetical-protein
MYSLPLKSKSLRFFNLVFIALVLSFYLLANANAAGIKRYDFGEMSSKVTKAWDQDVALYVARRFAAENGFDEKEITVKKLEAGATNHFIYLMFINNQLKFVLKGLGTEKEAEALFALQNYSKIPDIQSNPQAATVTLSKTINSYEVKNDRKTYYFAILEAAQGKELFKIMTYELLQHKDINTLKDVFYRIGQQTSELHKTIIGHDQFITPRDLVTVIHDDFHPENTFYNLETNVFSLIDNESMGDSITNPLPIIRELYGFYEVPIIRWPSEKITVDLLKDADPHDIASIYYDFVLGMASVYHDSQDAKRVLIAAIIDLNNMAIAFLKDRYSEPWMLNPSDKNEAHIVWGKLAKVADNPQLAELYINKLAIINTDLQSLSGLWLQQLH
>NZ_CP021257.1|WP_027227419.1|624139_625327_+|fatty-acid-desaturase
MFFGILNLTLWGYVLATFVLTQITIAAVTLYLHRYQTHRALTMHPIVSHFFRFWIWLTTGMVTRVWVAIHRKHHAMTDVEGDPHSPQIFSIKKVFWQVPELYREAAKDKDMIEKYSHGTPNDWIERKLYSRYSSKGILLMFLIDLLLFGFPGITIWAIQMIWIPLSAGVVNGLGHYWGYRNFECPDRSTNVFPLGILIGGEELHNNHHTYASSAKFSVKWWEFDLGWFYIRCLSFLGLAKVKKLPPKLAREDTKQCVDLNTVKAIISNRFQIMSDYYKRVTIPILKNEKRNCNYIKNRKEWHLFKEAKRLLRQETTKANAHLQVLLNRFEQLQLVYNYRQSLQQIWLKKVSSQKELIESLNQWCKKAEQSGLDVLHQFSLRLKSYVLIGTDGSSV
>NZ_CP021257.1|WP_011214444.1|623847_624015_+|DUF3309-domain-containing-protein
MLGTILLILLILLLLGSVPRWGYSRSWGYTPMGLIGLILVIYLILVLLGKVPIGF
>NZ_CP021257.1|WP_063720028.1|622892_623249_-|hypothetical-protein
MNLSVFSASELFAGADPEKVIQELTMVSKSYGSAISYHRLPAGSTKDLSEHSKYYLNLIDKAIEDVNLSLDDNSKATYSLRFALLQPLLVNLVAAAEVLKNEKTQEQEQKSSHSVRFM
>NZ_CP021257.1|WP_027227422.1|621882_622524_+|RsmD-family-RNA-methyltransferase
MKSSEICPFGPKLQQYWDKRYDYFHRFDEGIQTDSEGLHTVMPEEAALTQAKLFNNEKIVVDGFCGIGGSAIALARTGKKVIAIEMDSVRLAMAKNNARVYGVEHLITFVHGDFFDVAAEIKADAVLIDPPWGWPRYRKIEEFHLQHFNPNGSKLISYVLDHFNKIVLRAPKTFITSELDQFNVNYEIHSDKLHHSIISISVCITNHSKRKPG
>NZ_CP021257.1|WP_027227423.1|620436_621339_+|hypothetical-protein
MFPPLQDPWSELEKLGFNPDYLERLKKRAATSIELTKNIEMLAGYYERFKAAGFTDRDLARIVSLVSFTSDNRLSNIGSRMMLTLVCGGLDLLKAPLNFNSHNLTNMMVSLNGLEKLRQLVKINQSYMIPFKNQAEFKAVFEKKCKKYPMLRVVWCYSDKEELYLENRRQDAIYKDWLSEEELHQLFRLRRVSKSQDLYYWERDKLRPAFLSDNYYSREDLGQTREEFEKALDNADAVESWCDSWANPFDQNPIPKLAKILVPSNQKNTSKIPFFTAVDNNEKSSVIDERYSKYFSNCSK
>NZ_CP021257.1|WP_027227424.1|618820_620275_-|hypothetical-protein
MKNKTRALNFLNRIERCIVPQSNPQIMKQLLSALGLDNINTGNEEYKFFIQTIKRKAIDLNPLINKIKSDILKNKSLCTLLAYIEENELIDDAEIENASSTIQLQINLLCLLEAITITMANSNDFAHDIYNHMMKQRGGGATGNPFYNFLFGIPSRATLFERLKLISIDPGLTSIIFHRQMGANPETQADLNDFVSQNRLSGWNADIELANFDVASTSTLPAMGVNILEAVWEDSTGHNKNTSGIPNAQAGLGLIAIMEEKEYTTSFKLAETTLPQGTKLDSDLGYSLIPELKVDNSPKKVSQFHIDEQWMNLYNSWNLCFVIANIDPVFVPLKLLIPSVFSAEPSNYKETRVLTLFLVANLFLNQQTLNNPLFSNKFSFQNGAAILKKWGEINRNHASELMQQCSPKTGKEPEALYNRVLGKHAHLNFGLKLLSYFQDSHQFRLTKKAKQSALNDHSFFSGTAASADNSDQLNLASQPSLNKV
>NZ_CP021257.1|WP_027227414.1|628683_629601_-|LysR-family-transcriptional-regulator
MDKLNLNLLRALYALLTCRHLTLASKKMGISQSSMSIYLKQLREHFHDDLLVRGQGSIMQLTPLANSLIGKARQALSLIETLFNTIETFNPLISERSFSIGMTDLMSILLTPSLIKRLEQEAPGVKLNIKHPSYLNTVEVFESGDIDLMIGMFERVPESLKQQKLFQDEAVIVGGSNHPGIQKGKICIEELFKYPLIQFSLRETPFYNYFDRYLRQLGHDKRVSISLGQGIMPLFVLTDSHYLTLSIRKVAEKLSHLIPLSIASVPFEVDSFNCYQYWHQKDDADPGHRWLREMVLSIAKKSHLK
>NZ_CP021257.1|WP_027227413.1|629790_630264_-|hypothetical-protein
MRSRTEKLSSKRSIINHDHLITDEVCMIGIYREGGDLSIYAESPEGIEHFSINRGNNLDMVILPHTLVGTWRHHQLLRTVEQAAQIRTLRIRSHDYIEQSVTRTELEQFKEVFMLACKEEISNQPEIEDYLQTALGKLHGEAEMTYKPKFTEQCSIL
>NZ_CP021257.1|WP_031301595.1|630570_630819_+|hypothetical-protein
MLDEHQNLEYIKKLISFVTLKLNVRPGKYLKKTVDLFSMPGLLILSHESKEQVESDYNLVRKLEQKGLFVLAASQESKTTKI
>NZ_CP021257.1|WP_027227411.1|630834_631146_+|cupin
MQIIKSSLFTGDFTWQALDIAQISDASIRLHWADQPYIWHKNDGDEVFVVLSGKVIMHYREGGVENQKELNSGDICYLKEGCEHVAYPKGAARILVIEKAGSI
>NZ_CP021257.1|WP_028378828.1|632036_632783_-|ATP-binding-protein
MLNNPTLDKLRSLKLTGMADEFTEQLKRPVNDLDFEERLGLLVEREYLLRDNRKMERRLKQAKLQLNACMEDIDFKHPRGLNKSAMLELFRCQWVSQHLNLLITGPTGCGKTYIACALAHKACITGFSSRYYRLPRLWNELKIAKANGSYPNWLASIAKVDVLVLDDWGLVAPDEEQRRDLLEILEDRYQKRSTIITSQLAVALWHEHLGDATLADAVLDRLVHNSIRIELNGESMRKTKKSLQTKPL
>NZ_CP021257.1|WP_106331205.1|632794_634309_-|IS21-family-transposase
MRKIQEVFRQHEQGHSNRDIGRSLNISSGTVSNYLYRARVAGLTLAETLSLGEQQLYERLFLPSKASSTRRVLPDWECIHAELRKKGMTLMLLWREYRECHPDGVGYSQFCDRYKRYVKQISPVMRQVHKAGEKVFVDYAGMTVPWIEPSTGEIHEAQVFVASLGASQFTFVDITESQSLEHWITSHIRMWNYFGGVTKIVVPDNLKSGVSKSHRYDPDINANYQHVSEHYGVAIVPARAAEPKDKAKVENAVGCIERQILAPLRHHTFTSIAEIKKAIAPKLVAFNKQSFQKMNTSRLELFEALDKPALQPLPSEPYHYAEWKRAKVNIDYHFVFDEHYYSVPYQYIHKTIEVRTSGSMVECFHEGKRIALHTRSKKRFTHTTLAEHMPSSHKAHAEWTPERIHRWALKTGEDTVRYIEYMIAARAFPEQAFRSCLGLMRLAQRFGADRLENACAIALEAGMTRYQQVERLLKNNMDLVRTSSKTTTPVIPHHNNLRGSNYYQ
>NZ_CP021257.1|WP_027227409.1|635357_636263_+|LysR-family-transcriptional-regulator
MINNSLNLNDLAIFALVVKKRSFTQAALEAGISKAWVSQKISQLEGKLDIKLLNRTTRSLSLTLGGEILFEHCQTMLKEVIHAENHLREYAKAPSGKLVITCPEISGLDLFPTLLHQFKLLYPQIKIRLIITDQFVDLTQQGIDFAFRTGKLTDSGLVSRYIGAVPRCLVASPEYLSNNSPIKNPADLFNHQLLKHSSLPDWLLKKEEEVFKIHVKNPVIESNSLIFLHKISCLHHGIAFLPYYLCSDALKHKTLVKVLPDWLNVDNEYYMVYHKEKSVLYIHQLFKDFILQSDLNKMISN
>NZ_CP021257.1|WP_027227408.1|636302_636659_+|preprotein-translocase
MSDFVCVLMERRGRNKTSEFVFPDESRTGYIYEPQKAVNRVVELYGVPFTKHDFRRTFVTIADSLDLPADALKRLVNHKMNNDVTAGYIMKDVERLRKPMQQVANFILEHMMETAELS
>NZ_CP021257.1|WP_032832101.1|636693_637914_-|type-II-toxin-antitoxin-system-HipA-family-toxin
MKNHKLDIYLNQTLAGQLRIDTHGEMSFVYDEGYLENNKNLPLSHSLPLQQAPYSTKQCRPFFSGLLPEAHMRTAIARQLGISEKNDFALLAAIGGECAGAVMILPQDTSITQLKPDYKIIKKQDVLEILQTMHQRPMIVGEDGIRLSLAGAQDKLPVAIIEGNLAIPMNGAPSTHILKPINRDVPSLIENESFCLNLAQKIGLNAVDASIHYADGTPYLLVKRYDRVETKQGIQRLHQEDFCQAMGISPEMKYQREGGPQISECFGLIREISSLPVLDIKELLQGILFNVIIGNNDAHSKNFSLLYHGSKVRLAPFYDLISTVYYPNLASKMAMKVGSKYDFDGLFPRHFIQMAEEARLSGALVRKEVLNLISKIQKNITASPFTSIILQRADKLFQKFQKASTG
>NZ_CP021257.1|WP_027227407.1|637900_638128_-|helix-turn-helix-transcriptional-regulator
MIQSPENIGRYIRKVRKELNVTQKDLALTAGTGLRFIIDLENGKPTCQIGKMLQVLQVLGIQLNLSHTDFENEKS

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Crispr_ID: NZ_CP021257_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021257_3

664204-664309

Orphan

Consensus_repeat	Method
GAGTGCCCCCGTAATTGGGAAAGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021257_3

>merge|NZ_CP021257|3|664204-664309|CRISPRCasFinder
GAGTGCCCCCGTAATTGGGAAAGACCCCAATTTTATCTGATAATTATAGAACAAGTGTTAGGGTGTTGTGTTGTTAATTGGGGAGTGCCCCCGTAATTGGTAAAGA

>NZ_CP021257|3|3|664204-664309|CRISPRCasFinder
GAGTGCCCCCGTAATTGGGAAAGA	CCCCAATTTTATCTGATAATTATAGAACAAGTGTTAGGGTGTTGTGTTGTTAATTGGG
GAGTGCCCCCGTAATTGGTAAAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021257.1\|WP_028378768.1\|672511_672715_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_181049475.1\|652810_653035_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379306
NZ_CP021257.1\|WP_028378774.1\|666226_666664_-\|conjugal-transfer-protein-TraM	unknown	unknown	gnl\|CDD\|184378
NZ_CP021257.1\|WP_106331205.1\|650420_651935_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP021257.1\|WP_027227397.1\|652353_652806_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_028378827.1\|663022_664198_+\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|376574
NZ_CP021257.1\|WP_028378772.1\|667388_667733_-\|TraK-family-protein	unknown	unknown	gnl\|CDD\|379959
NZ_CP021257.1\|WP_028378769.1\|671262_672363_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_028378775.1\|665315_666185_+\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NZ_CP021257.1\|WP_080274386.1\|668478_670077_+\|relaxase/mobilization-nuclease-domain-containing-protein	unknown	unknown	gnl\|CDD\|237539
NZ_CP021257.1\|WP_027227392.1\|655835_657587_+\|DUF927-domain-containing-protein	unknown	unknown	gnl\|CDD\|336282
NZ_CP021257.1\|WP_027227395.1\|653105_653924_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|227186
NZ_CP021257.1\|WP_027227394.1\|653892_654873_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227198
NZ_CP021257.1\|WP_027227393.1\|655493_655769_+\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP021257.1\|WP_027227391.1\|658845_659100_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_028378771.1\|668128_668482_+\|conjugal-transfer-transcriptional-regulator-TraJ	unknown	unknown	gnl\|CDD\|184361
NZ_CP021257.1\|WP_028378770.1\|670561_671230_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_027227389.1\|660983_662825_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379050
NZ_CP021257.1\|WP_028378776.1\|664710_665319_+\|AbiEi-antitoxin-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379128
NZ_CP021257.1\|WP_028378773.1\|666663_667389_-\|conjugal-transfer-protein-TraL	unknown	unknown	gnl\|CDD\|184370

Protein	Function_ID	Function_description	E-value
NZ_CP021257.1\|WP_181049475.1\|652810_653035_-\|hypothetical-protein	gnl\|CDD\|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	0.00349557
NZ_CP021257.1\|WP_028378774.1\|666226_666664_-\|conjugal-transfer-protein-TraM	gnl\|CDD\|184378	PRK13895, PRK13895, conjugal transfer protein TraM; Provisional.	9.47181e-62
NZ_CP021257.1\|WP_106331205.1\|650420_651935_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	3.17347e-35
NZ_CP021257.1\|WP_027227393.1\|655493_655769_+\|DNA-binding-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	0.00413771
NZ_CP021257.1\|WP_028378827.1\|663022_664198_+\|ISL3-family-transposase	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	1.10492e-70
NZ_CP021257.1\|WP_028378772.1\|667388_667733_-\|TraK-family-protein	gnl\|CDD\|379959	pfam17273, DUF5338, Family of unknown function (DUF5338). This is a family of unknown function which can be found mostly in Proteobacteria.	6.01933e-25
NZ_CP021257.1\|WP_028378775.1\|665315_666185_+\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	4.02262e-42
NZ_CP021257.1\|WP_080274386.1\|668478_670077_+\|relaxase/mobilization-nuclease-domain-containing-protein	gnl\|CDD\|237539	PRK13878, PRK13878, conjugal transfer relaxase TraI; Provisional.	0
NZ_CP021257.1\|WP_027227392.1\|655835_657587_+\|DUF927-domain-containing-protein	gnl\|CDD\|336282	pfam06048, DUF927, Domain of unknown function (DUF927). Family of bacterial proteins of unknown function. The C-terminal half of this family contains a P-loop motif. The N-terminal domain appears to have a unique fold, which contains three Helices and two strands. Structural analyses show that helicases containing this domain form a hexameric ring with a positively charged central pore threading a single DNA strand through suggestive of a replicative function for this helicase.	6.57265e-137
NZ_CP021257.1\|WP_027227395.1\|653105_653924_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|227186	COG4849, COG4849, Predicted nucleotidyltransferase [General function prediction only].	1.33123e-38
NZ_CP021257.1\|WP_027227394.1\|653892_654873_-\|hypothetical-protein	gnl\|CDD\|227198	COG4861, COG4861, Uncharacterized protein conserved in bacteria [Function unknown].	1.72608e-36
NZ_CP021257.1\|WP_028378771.1\|668128_668482_+\|conjugal-transfer-transcriptional-regulator-TraJ	gnl\|CDD\|184361	PRK13877, PRK13877, conjugal transfer transcriptional regulator TraJ.	1.73225e-58
NZ_CP021257.1\|WP_027227389.1\|660983_662825_-\|AAA-family-ATPase	gnl\|CDD\|379050	pfam13175, AAA_15, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	1.07186e-20
NZ_CP021257.1\|WP_028378776.1\|664710_665319_+\|AbiEi-antitoxin-N-terminal-domain-containing-protein	gnl\|CDD\|379128	pfam13338, AbiEi_4, Transcriptional regulator, AbiEi antitoxin. AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	3.61645e-10
NZ_CP021257.1\|WP_028378773.1\|666663_667389_-\|conjugal-transfer-protein-TraL	gnl\|CDD\|184370	PRK13886, PRK13886, conjugal transfer protein TraL; Provisional.	1.28665e-176

>NZ_CP021257.1|WP_028378827.1|663022_664198_+|ISL3-family-transposase
MPKHNLILNLPGFTIQKVSGYQPLILDISYHRLPRCAHCHSKAVRKKSSYIRTVAHELIGHRRSLLRFKAYKLYCNTCKRYGNQQFPGINKHQRSTWRLQSAVFHDHTRGISQKDLAQQFKKGKATIERWYHRQYQEQAKELMNTPCPIVLGIDEHFFSKKQGFATTLCDLKKHKIFDIVKGRSEADLSSYLASLVGKERVKVVCMDLSSTYRSIVKKHFPNAKIVADRFHVIRLLQHQCMMTYRELSSQVKSNRGILALLRTRPDRLTPQRRLKRDAFLEDNPAINAIYQFQQQVHTLLLHKSMNKDWCKKMIPQFLNMLDDLKSSPFKALAALGKTFCLWKEEIVRMWRFRKSNGITEGFHRKMKLIQRRAYGFRNFENYRTRVRVLCC
>NZ_CP021257.1|WP_027227389.1|660983_662825_-|AAA-family-ATPase
MRACRIDIKNFRGISKATILFPKHGVLIGDNNTGKTTTLEALDLVLGPDRLNKYPPIDEHDFFRGKYRTEPTDVTDKTVNSDKSSNTQEEIKDKSTEIPHIEIEVTITDLTEEQQAKFGDYIEFWDSTTNTLYVKPDPAGIDQVHISEALRVTFHGQYNEEEDDFEGKTFFTRSLTENDTPQPFTKKDKQVCGFLYLRSIRTGSRALSLERGSLLDIILRLKEIRPQMWEDTLQVLSQTEVASNPDLGISPVLESINKSLKKYVPSEWGIEPHLRVSSLTREHLRKIITAFITTDDGNHSAPFYRQGSGTINMLMLAMLSQIAERKQNVIFAMEEPETAIPPYAQKRIVHEVRKLASQTLFTSHSPYVLEEFDIEETIILGRNSDGLLIQKKISLPSNVKLKRYRQEFRTRFCEGLLARRVLIAEGPTEASAFPAVCRRLAELNPDTYASLEELGICTLDADGESNISGMAQLYRDLGKKTFALCDKQSDESKTLIESQVEVILMHQEKGFENLILNNTTETALQRFARLIDWPQHLLQKYPNPEQQASTAVPEYLRKHKGEGVCADFLAQCYETEIPKWLRDACIQLKATCTSSLIAEEAQASSRVDENATD
>NZ_CP021257.1|WP_027227391.1|658845_659100_+|hypothetical-protein
MAKYPALLKSSEICIAKRAIKCAFNKKHVMKKGDIYLLIKSSTIKFPFSLEKKYCNQCATHILNDAEMNLKSIIAARIELQGKI
>NZ_CP021257.1|WP_027227392.1|655835_657587_+|DUF927-domain-containing-protein
MSQNHVIELDNTLKQRPIVCDYAGGRFRLTAEGLTFIGIDKDGTPLPPRWICPPLYVVAKTRDAQSGEWGRLLEWQDDDGVTHQWAMPLALLQGDASDVRRELARLGLSISPNRTARDLLASYLQVFPVDARARCVDKLGWYGDVFVTASQCIGNSTEKIVFQNTNAIEPAVSVKGSVEEWRDSIGRLASGNSRLVFAISVALAPVLAKIVGEDSGGFHFRGASSSGKSTALSLAASVWGNPQSYCRLWRSTTNGLEGLAALHNDGLLILDELSQMDPREAGEAAYLLANGQGKTRASRTGTVRQSSRWSLFFLSAGEESLTALMAKSGQRINAGQEIRLADIEADAGSQIGIFEMIHDQLSPASMALSLKKYSSRYHGAIGLAWLNQVVANRQTISRYITDTIQTFIDSVIQPDATGQIIRVARRFALVAAAGELASQFGLTGWQKGESFQAAKACFIAWQDTFGVDGQREDRAIMAQVRAFFESHGASRFDNANSPNNDKILNRAGFYHTDNEGFRVYMVLTETYKNELCKGFEQRAVTRVLLQAGWLKPASDGKASHKPRIKGVGTPRLYVFTGKIWGGE
>NZ_CP021257.1|WP_027227393.1|655493_655769_+|DNA-binding-protein
MSLQKPTRLHLLNEFESAPHSALFNQQTIAAVLSCSTQLLERNRWAGGGVPYLKIGRKVLYRKSDVVNFLQQQKIYYSTSDEGQLQLVENA
>NZ_CP021257.1|WP_027227394.1|653892_654873_-|hypothetical-protein
MNTEQLISNIKDKLGFQCKYDKKINQLYIYIKPHTELSFNPEMIGNIDQTNVGAIIQHMHHLDKKSILITKYINKNLAEKLQNANIEYIDFSGNMFINTDPVYISIKGETPQKSNQLDTNSFTLSVASIKIIFTLLTMKSALNHNYRDIAKMSDVALGSVSKTFSILEKYGYITEKTHGEKVLLNKENLLSKWCIGYNEKLRPKLMIEKFNSDSLEKLKETNPIDFNFLWGGEIAAAKLTQYLKPKIITLYAENELPLLQYKYRLKKNINGNIELIKKFWNFDTKLYNHNVVPFILIYADLLSSSDERNQETAEIIYDKFIKEQME
>NZ_CP021257.1|WP_027227395.1|653105_653924_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MTNSLKNKWNSFSEENIDLFKLINKISLINNCTYFLIGAKARDILLEYFGKNEAQRATLDTDIAICCKSWEEFYKIKNTLIEKSDFVVYQKSEHRLQSNKYGYLDIVPFGDIKDENSTLKWPPEYDIEFSLTGFDDAYQRSMDISISDLTIKVASPLGLALLKLFSWLSRKANKDASDLAYIISNYFDFDDQDRLNGKHHDLLEKDFDYTLSGCRLLGRDFKELSLETKIRLKELFDDPILMDNLAISITHSQLEYVHALSMLEMIKKGFND
>NZ_CP021257.1|WP_181049475.1|652810_653035_-|hypothetical-protein
MLKKVDFILENHARKIIGIEVKASQTILNQDFRSLRKLASLADKNWVSGIVLYSGDKCLSFGDNLWAVPFTFLD
>NZ_CP021257.1|WP_027227397.1|652353_652806_+|hypothetical-protein
MPPVEVIQSCKNNNPANKSVLMTEIEGIGYNKDSEPNCKNQFDTEIGGKLYGSATCDDKPYLIIADHKIKVESANNYSTNPAIKPTTAIAQVAGWWKIVDSKKQTYICIESPLSNTGTASNAYQYFIVADPFNEKKSNFDVSFYFFEKKE
>NZ_CP021257.1|WP_106331205.1|650420_651935_-|IS21-family-transposase
MRKIQEVFRQHEQGHSNRDIGRSLNISSGTVSNYLYRARVAGLTLAETLSLGEQQLYERLFLPSKASSTRRVLPDWECIHAELRKKGMTLMLLWREYRECHPDGVGYSQFCDRYKRYVKQISPVMRQVHKAGEKVFVDYAGMTVPWIEPSTGEIHEAQVFVASLGASQFTFVDITESQSLEHWITSHIRMWNYFGGVTKIVVPDNLKSGVSKSHRYDPDINANYQHVSEHYGVAIVPARAAEPKDKAKVENAVGCIERQILAPLRHHTFTSIAEIKKAIAPKLVAFNKQSFQKMNTSRLELFEALDKPALQPLPSEPYHYAEWKRAKVNIDYHFVFDEHYYSVPYQYIHKTIEVRTSGSMVECFHEGKRIALHTRSKKRFTHTTLAEHMPSSHKAHAEWTPERIHRWALKTGEDTVRYIEYMIAARAFPEQAFRSCLGLMRLAQRFGADRLENACAIALEAGMTRYQQVERLLKNNMDLVRTSSKTTTPVIPHHNNLRGSNYYQ
>NZ_CP021257.1|WP_028378776.1|664710_665319_+|AbiEi-antitoxin-N-terminal-domain-containing-protein
MKTEATYKQKVLQMASKSGIVRMSDLTERGITRATISRLVSENKLEKLASGLYCLPETEFSEKESLVIIASRVPQAVFCLLTALQIHDLTTQLPRKVWIAMPKGSHAPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYNFAKTIADCFKHRNKIGLDVAIEALKEAYTKNKVTVDELWHYAKICRVANVMRPYIEAIQ
>NZ_CP021257.1|WP_028378775.1|665315_666185_+|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MTKNIGESVRSRLKNIAVKEGSDFNAVLTRYGLERLLYRIGESEYSKQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDNDLAYIKQTFSKICRISADDGISFLSESVTADTIKKDGGYTGARVELFGELAKAKIKIQIDIGYGDAVTPGPIDAHYPVLLSDLPAPKIRTYPIYTVIAEKLHAIALLGMTNSRLKDYLDLYVLLGNEQIDNQILAKAIHATFNRRSMDLPEELPIGLTDEFANDPSRESMWKAFLRKNELEQKSLTEVIAVIRNLIQVPYSLSTHPNFSR
>NZ_CP021257.1|WP_028378774.1|666226_666664_-|conjugal-transfer-protein-TraM
MSEKLDKIIQDISIKHGVLLGKDDPILMLQTMNAQLIEEHRKAQQDLLVQFREEMEGISSQWKDDAKEKAEKVLNAALASSKEAITRLLNESTKESVQAMQKLILNSLTEAHSLTRKTQKFSQFVLVLSATLFVASCMIFLLFYK
>NZ_CP021257.1|WP_028378773.1|666663_667389_-|conjugal-transfer-protein-TraL
MAKIHITLQGKGGVGKSFISATTAQYKQHKGHTPLCIDTDPINSTFHGFKALNVDHIQVMSGDEINPRLFDALIEKIASTTNDVVIDNGASSFVPLSHYLISNQVPALLKELGHEMVIHTVITGGQALFDTINGFAQLIDQFSNEAQFVVWLNPYWGAIEHEGKAFEQLKAYRDNKDRISALIQIPDLKKETYGRDLTEMLQQKLTFDEVLGMPEKSIMTRQRLKIVRDQLFGQLDSARVI
>NZ_CP021257.1|WP_028378772.1|667388_667733_-|TraK-family-protein
MGNSLSERIAAKQMLRKASAKSVNKAAFLALKNDIASALADGWSIKLVWETLVEEGKISFSYKTFCGYVARLIAAEKKPSMQENTKDDEKAKSKAKTEIRGFTFNPKPNLEELL
>NZ_CP021257.1|WP_028378771.1|668128_668482_+|conjugal-transfer-transcriptional-regulator-TraJ
MDKKLKTPTRKNGRHLRVPVLPSEEIQIKSNAAKAGLSIAEYLRRVSLGYPIQSTVDKDCILQLSKINADMGRLGGLLKLWLSQDKRVAHFDQRLVMSLLSKIRLTQDAMLDVVKKL
>NZ_CP021257.1|WP_080274386.1|668478_670077_+|relaxase/mobilization-nuclease-domain-containing-protein
MIIRHIPMKSARLSSFSSLVRYIIDTQNKQERVGKIRLSNCNSFDPIWAVQEVLATQAKNQRATGDKTYHMLISFAPGENPSAQVLQEIEDTVASSIGFKEHQRISVVHHDTDNLHIHVAINKIHPQTFNMIEPYRAYKTFAQAASKLEIELGLQITNHQTRKNHSENLADDMEHHSGIESLINWMKRYCKEKIEAASSWKEIHSILAEHGLIIRIKANGFVFCNIQGLTVKASSISRTFSKKNLESKLGSFVPSYPEDDRPASNVYHYEPLNKKVLGTNLYAKYQYEKSHNKCFVSDQLKKLREARTKLIEKAKKRGRIKRVALKLMNLSKAQRKYLHQHINKTLHNEIENIRKNYAKERGQLLNSHQKKTWADWLKQQAQGGNQDALMAMRCRNRKNTHKNSISGLGSTFSSSLNFGQIDSITKEGTEIYKKDNSVIRDNGKEIIISKDGSIPTLKRALEMARQRYGDCICVNGSPLFKKIILQIVIQYQMPITFADLDLENQRQKPNFEQEKSHEQSRSNGQSHRGRTS
>NZ_CP021257.1|WP_028378770.1|670561_671230_+|hypothetical-protein
MGIKIAVWGVGSLINPVVFKSNEDLPKSDNPADFIIANKPFLKLTLDILHQNNITSVMGSQRVQRNEEDKVYGKYIKNIYIGLDRIFGKKRPYLREVDEIFQKVNSDGIIFIDDSDEYNQSLKQAGQIFVNVSREAKPGSVEGNAFLYETLLRTIPSSKIHEAIKNSKESGTVKKEFKKQLLTFQLDNLDKVKLWQQQILSEENILSVESSKKLSSVRRKKP
>NZ_CP021257.1|WP_028378769.1|671262_672363_+|hypothetical-protein
MNTRWDIGYFGGLKVTDRETGIKNTVPKGMGKILQEIDKVQNGDSTWNKAFENIEEILKKSAEENEHGFFNRRGETTQIFYEKSKKILSDLRSKPEVVVKQLSISPEKHDLGIVISEPEENTSNNNRALEQPVAVKVKNSIGGISSDKLFISESGYAYNVDDIIKNFRKLDGPVIFVDYLNPDSQESTIHFTTNDIQQLLDFPSIKEAVYKLCSPKDQQEDRLIELAELANNIPQEVLDAMYEVHKIGVAIPFQKRANESEYSVLMSPSMIALNEAVNKMTPAEKLSLKLFMDIMPYNYEIMRSVSRTPPTGPSMLEEDLRKQLNEGKCGNGFAEAMKVLPDIIRSFQEIQKVSEQGYFTQSKITP
>NZ_CP021257.1|WP_028378768.1|672511_672715_+|hypothetical-protein
MKDEAFKLVRDRSKKEWKIKSKYQPRSFAETGVFLVKTLMRNKLTACTFECHYNEWFYGVTSLIKSL

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Crispr_ID: NZ_CP021257_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021257_4

1633154-1633357

Orphan

Consensus_repeat	Method
CTCATAAAGGTCATTACATCTCAAATCAAG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP021257_4

>merge|NZ_CP021257|4|1633154-1633357|CRISPRCasFinder
AATAAAAAGCCCATTACTGCTTAAATCAAGCTCAGTGACATTGTTTGGAATATTTTTTAGAACCTTACCCAGGCCGTCAGCACCTAGCTCATAAAGGTCATTACATCTCAAATCAAGTATGACGATGCTCTTTGGAAGTACAGTTAGCATGGTTGTCAGACCATCAGCACCTAACTCACAAAGGTCATTACATCTCAAATCAAG

>NZ_CP021257|4|4|1633154-1633357|CRISPRCasFinder
AATAAAAAGCCCATTACTGCTTAAATCAAG	CTCAGTGACATTGTTTGGAATATTTTTTAGAACCTTACCCAGGCCGTCAGCACCTAG
CTCATAAAGGTCATTACATCTCAAATCAAG	TATGACGATGCTCTTTGGAAGTACAGTTAGCATGGTTGTCAGACCATCAGCACCTAA
CTCACAAAGGTCATTACATCTCAAATCAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021257.1\|WP_027227105.1\|1628389_1629370_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_027227096.1\|1641572_1642997_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021257.1\|WP_027221798.1\|1627091_1628039_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CP021257.1\|WP_027227099.1\|1637029_1639345_-\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|225227
NZ_CP021257.1\|WP_027227109.1\|1624472_1625429_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|377252
NZ_CP021257.1\|WP_028378125.1\|1621234_1622695_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP021257.1\|WP_027227102.1\|1631347_1632601_+\|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|234685
NZ_CP021257.1\|WP_027227095.1\|1643821_1644886_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375919
NZ_CP021257.1\|WP_028378124.1\|1626018_1626768_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CP021257.1\|WP_027227094.1\|1645049_1646369_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|181265
NZ_CP021257.1\|WP_027227097.1\|1640784_1641462_+\|RES-family-NAD+-phosphorylase	unknown	unknown	gnl\|CDD\|378053
NZ_CP021257.1\|WP_027227098.1\|1639565_1640222_-\|methyltransferase	unknown	unknown	gnl\|CDD\|226608
NZ_CP021257.1\|WP_027221790.1\|1640408_1640783_+\|Y4oB-family-protein	unknown	unknown	gnl\|CDD\|378249
NZ_CP021257.1\|WP_106331205.1\|1634238_1635753_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP021257.1\|WP_027227110.1\|1622687_1624469_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP021257.1\|WP_050598509.1\|1635951_1636470_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238064
NZ_CP021257.1\|WP_028378123.1\|1630268_1631339_+\|glutamate-5-kinase	unknown	unknown	gnl\|CDD\|235460
NZ_CP021257.1\|WP_028378828.1\|1633480_1634227_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|366760
NZ_CP021257.1\|WP_027227104.1\|1629659_1630085_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP021257.1\|WP_027227108.1\|1625425_1625953_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181

Protein	Function_ID	Function_description	E-value
NZ_CP021257.1\|WP_027221798.1\|1627091_1628039_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	1.42202e-39
NZ_CP021257.1\|WP_027227099.1\|1637029_1639345_-\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|225227	COG2352, Ppc, Phosphoenolpyruvate carboxylase [Energy production and conversion].	1.9644e-56
NZ_CP021257.1\|WP_027227109.1\|1624472_1625429_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|377252	pfam04229, GrpB, GrpB protein. This family has been suggested to belong to the nucleotidyltransferase superfamily. It occurs at the C-terminus of dephospho-CoA kinase (CoaE) in a number of cases, where it plays a role in the proper folding of the enzyme.	2.95879e-75
NZ_CP021257.1\|WP_028378125.1\|1621234_1622695_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.55237e-85
NZ_CP021257.1\|WP_027227102.1\|1631347_1632601_+\|glutamate-5-semialdehyde-dehydrogenase	gnl\|CDD\|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	0
NZ_CP021257.1\|WP_027227095.1\|1643821_1644886_+\|hypothetical-protein	gnl\|CDD\|375919	pfam18493, DUF5617, Domain of unknown function (DUF5617). This is a C-terminal domain of unknown function found in gammaproteobacteria.	0.00124043
NZ_CP021257.1\|WP_028378124.1\|1626018_1626768_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	1.4447e-48
NZ_CP021257.1\|WP_027227094.1\|1645049_1646369_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|181265	PRK08170, PRK08170, acetyl-CoA C-acetyltransferase.	0
NZ_CP021257.1\|WP_027227097.1\|1640784_1641462_+\|RES-family-NAD+-phosphorylase	gnl\|CDD\|378053	pfam08808, RES, RES domain. This presumed domain contains 3 highly conserved polar groups that could form an active site. These are an arginine, glutamate and serine, hence the RES domain. The domain is found widely distributed in bacteria. The domain is about 150 residues in length.	1.67994e-28
NZ_CP021257.1\|WP_027227098.1\|1639565_1640222_-\|methyltransferase	gnl\|CDD\|226608	COG4123, COG4123, Predicted O-methyltransferase [General function prediction only].	9.4923e-17
NZ_CP021257.1\|WP_027221790.1\|1640408_1640783_+\|Y4oB-family-protein	gnl\|CDD\|378249	pfam09722, DUF2384, Protein of unknown function (DUF2384). Proteins in this family are found almost exclusively in the Proteobacteria, but also in Gloeobacter violaceus PCC 7421, a cyanobacterium. The function is unknown.	1.89824e-05
NZ_CP021257.1\|WP_106331205.1\|1634238_1635753_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	3.17347e-35
NZ_CP021257.1\|WP_027227110.1\|1622687_1624469_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	6.81973e-134
NZ_CP021257.1\|WP_050598509.1\|1635951_1636470_-\|hypothetical-protein	gnl\|CDD\|238064	cd00116, LRR_RI, Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).	1.70844e-08
NZ_CP021257.1\|WP_028378123.1\|1630268_1631339_+\|glutamate-5-kinase	gnl\|CDD\|235460	PRK05429, PRK05429, gamma-glutamyl kinase; Provisional.	6.41605e-128
NZ_CP021257.1\|WP_028378828.1\|1633480_1634227_-\|ATP-binding-protein	gnl\|CDD\|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	2.54556e-68
NZ_CP021257.1\|WP_027227104.1\|1629659_1630085_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.29365e-12
NZ_CP021257.1\|WP_027227108.1\|1625425_1625953_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.74582e-10

>NZ_CP021257.1|WP_027227102.1|1631347_1632601_+|glutamate-5-semialdehyde-dehydrogenase
MNTHVVNQLRAAKKATTDLSLIQSDTRTEVLKTLAANLEKHLENIIQENQKDLSLMPEQDPRYDRLLLSKERILSLANDVRKVADLPNPLGVNLLEKSMPSGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVSILKGGKEAYFTNSYLVLLIKNTLKNFNINTDLVCLLPPERALMTQLLNATGFVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLEKGKKIINNAKTRRVSVCNALDTLIIHTDRLKDLPELVEALSKNNVIIYADKEAYQALDKSYPEQLLMRAKPQDFGHEFLDYKLAIKTVPNIQAAIDHIQQFSSHHSEAIIAEEESAIDKFLIEVDAAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLDALTSYKWVIRGTGQIRN
>NZ_CP021257.1|WP_028378123.1|1630268_1631339_+|glutamate-5-kinase
MKIIIKVGTQSILSADGSPIYSVLNNLVNQIIYLKNLGHQVILVSSGAVGSGRKIAKNSLGKTYGDTVGEKQLLASIGQPELMNLYSNLFKNENILVSQLLLTKQDFHTRQHYLNIARLLTELLKHQNIIPIVNENDSVAIEELMFTDNDELAGLIAAQINADYLILLTNVDGVFTSHPNDPGAKLINRIDPNLAWPNVSAVTSKLGRGGMVSKLDTARKMAGLGINTAIANVNVESIVLKILDREAVGTIILASKRKSSIKRWIAFSHRTCLPSIVINDNLIALLRNGNRVMSILPIGIEDFRGECKKGDLIDILNSNNEKIGVGIARYDFLRLKDYLRLQNKPAFIHYDHLHIL
>NZ_CP021257.1|WP_027227104.1|1629659_1630085_+|GNAT-family-N-acetyltransferase
MNYQFELVVDTKLLEQQDKMIRDGIVNFNAPFTGSKPERYSIYVKDNENNIVGGAIVYAHKSSIYVDVLWVSEKYRGQGIGAELLRSVETEAVKRGILESTLDTFSFQAEGFYLKQGYKHLGTIKNYLEGHDRIYLRKKLK
>NZ_CP021257.1|WP_027227105.1|1628389_1629370_+|hypothetical-protein
MQLKSETKSTFHGKYSKSSPVVGARVKELELIYTHKEIFANYQKVVYDQQKLNVIPLAFKEKADEISKEIYAAYIKKYSDHGLTIENSVDWNNVGFTRTYLSDLENEWNTWSVDPLVATPNDKSHIEGQMYRPAYICALHELMHVEEMTPGILKGQYARFKSVVEVLTVTKTIILMDEVYKKTLNLPMDIEVDYENSFKLFGKTIKQGEFANFYRTLEAKYPSLAEALVSKQSLTFLNQTNVEPMNINMQVLGGFLAVVGYAAVALAFLLNNASFGTVGLVVTGLGVASIFGGVGLFANGIYKNERTTDNEILDASACLVRNTNSP
>NZ_CP021257.1|WP_027221798.1|1627091_1628039_+|MerR-family-transcriptional-regulator
MTQWFVKDLSQLTGVSVQTLHHYDRIGLLKPSLRLANGYRVYSEKDLLKLQQIIALKFFGFELSQIKTLLAEESNALSHFNSQARLLEQKASTLLEGAKTLRRIIDTVDKNQSIPWETIIQLIEVYKMTEHLEHGWVKEIFTPDELKQYVEFEKEMKANATPEQKAAMENNWSQLVNEVKNNLKQDPDSKTGVYLGKKIMDWVNGVYGKKYAHLRTKKFEQGFGEGKGLDEVGLTPEIVSWMDKAMDAYWRDRIYGILEQVGKTSSSIVLNLWNEMLVDMYGEETSRKNAIYEIALNDDKVSPEAKAWLRNILNS
>NZ_CP021257.1|WP_028378124.1|1626018_1626768_+|MerR-family-transcriptional-regulator
MAYTVKQLAKISNVSVRTLHWYDEIGLLKPAYQGANGYRYYEEKQCLKLQQILFFRELGFPLNDIQKLLMQNDFDHIKALRAHKQILERDINRKNQLIATIDKTIQHLRGKHKMSNEELYYGFDSQRQKQYERELVKEGVVSQDWMDKYKKKINQWTQADKDRFIQEGKEINQLLISAINNQLKPSSPEVQAIIHRHHAWVGWNPTKEGYIGLSQRYLTPEFRKFYEQQHPALLEFIIEGMLFYANKNL
>NZ_CP021257.1|WP_027227108.1|1625425_1625953_+|GNAT-family-N-acetyltransferase
MTQIEIVIKTQELSDIPVLVDAFQKANWQKPASLFEAYYQEQRKSLRIVWLAYSRDQIAGYATLKWISQYQPFAHQQIPEIMDLNVLPSFRKQGVGTALMQAAEEKAAGESDVVGIGVGLYGGHDGGYGQAQRLYVNRGYIPDGLGVTYGYKPTVPGQTYPLDDDLILWFTKKLR
>NZ_CP021257.1|WP_027227109.1|1624472_1625429_+|GNAT-family-N-acetyltransferase
MSVKQEQHLIKVVPYDSSWSMQFEQEAEQIKKALGNNCIDIHHIGSTSVPGLAAKPVIDMIPVILDLSKVDSANTAMRTLGYEAKGEYGIPFRRYFQKGDNQRTHHAHVFELGNSEIERHLKFRDWMRSHPEDREAYARLKQELARQYSDDITAYCLGKEDFIAIIDKKAGFNGLRMVKALTPREWDKVRHFRQFYFFDKAGLSDPYTWTFEHDAHVHFVLFQGSEIIGYTHLQLWPHNRAALRIIVIDELKRNHQYGNRFLTLCEKWLKSQGYQSLHVESSPDALRFYRNNGYIDMSFDDPDGYEGDPRDTAVGKIL
>NZ_CP021257.1|WP_027227110.1|1622687_1624469_+|ABC-transporter-ATP-binding-protein
MTNRLPNHLGSFVWHFLKPYRNIVMLFILFALLAGFWGPFNSLLVKSFINTLAAKASKDLSSLYWIAGLLVLNFIVFDNITWRTLGYLNYKYEAVIKNQIISQTFEYVLGGSTQFFQDNLSGRIADQITTLADNLEIILHRVSVDFLRGASLLVVSFITAYFVNVLFFYILFLWFIAFASFSIWMSARLVQLSDNHASSESQLSGQLVDSLANQSNIRIFSRKIYEVERMNAFFRMVQRAFQRKELFIVLLCCAQGGMIAVMMGFASITLIHLYGKGLVSIGDFALILGLSMELGHMMWYTMYQVDQFNQALGKAKQSLNALVIPHEIKDKGNASQLVVTQGQIEFSRVKFHYQGGYSLFQNKSVTIKAGQKVGLVGYSGSGKSTFVNLILRLYEVVEGQILIDGQNLSEVTQESLRQAIAMIPQDPTLFHRSLMDNIRYGRTDATDEEVILASRKAHAHEFISLLPEGYKTLVGERGVKLSGGQRQRIAIARAILKNAPILMLDEATSQLDSITESNIQESLWELMQGKTTLVIAHRLSTLLHMDRILVFDKGHIVEDGNHDELLKRGGLYKTLWNAQVGGFLPDQQNEKGE
>NZ_CP021257.1|WP_028378125.1|1621234_1622695_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MNHKPIQFKDISLNFSHKSCFQNFSGEIHFGDRIALIGRNGSGKSMLLKMLCGLSLAPAGEIKVPRDVRFGHLPQVLEDYPDLSGGQRLNQVLSKILSDKPNVLLLDEPTNHLDSRNRRSLMRMLKYYPGTLIIASHDTEFINTVTDILWHIDLGQVTVFRGAYFDYQQMLEDKKASIKQGLSRIAQQKKESHLALMKEQERNKRARVQGEKKIAQRKWPTIRSHTKLGSAITTGNKRLSHINYKKQQLIEELSSLNLTEVIQPKFKLKGLEHHKLLIRIQDASIAYESGVILKDIYFHLSGCERVALHGNNASGKSTFVKAILGDSQIKRTGEWAVPNCNTIGYLDQHYQHLNLNETVLDLMSSKMPHATYAEIRAHLNDFLFRKNEEVEIKVKSLSGGEKARLSLALIAAQPPKLLILDEITNNVDLETRTHIIEVLSEFPGAMLVISHDHDFLESIHIETKYQIHQGKLYGFNDAYLEVIHHD
>NZ_CP021257.1|WP_028378828.1|1633480_1634227_-|ATP-binding-protein
MLNNPTLDKLRSLKLTGMADEFTEQLKRPVNDLDFEERLGLLVEREYLLRDNRKMERRLKQAKLQLNACMEDIDFKHPRGLNKSAMLELFRCQWVSQHLNLLITGPTGCGKTYIACALAHKACITGFSSRYYRLPRLWNELKIAKANGSYPNWLASIAKVDVLVLDDWGLVAPDEEQRRDLLEILEDRYQKRSTIITSQLAVALWHEHLGDATLADAVLDRLVHNSIRIELNGESMRKTKKSLQTKPL
>NZ_CP021257.1|WP_106331205.1|1634238_1635753_-|IS21-family-transposase
MRKIQEVFRQHEQGHSNRDIGRSLNISSGTVSNYLYRARVAGLTLAETLSLGEQQLYERLFLPSKASSTRRVLPDWECIHAELRKKGMTLMLLWREYRECHPDGVGYSQFCDRYKRYVKQISPVMRQVHKAGEKVFVDYAGMTVPWIEPSTGEIHEAQVFVASLGASQFTFVDITESQSLEHWITSHIRMWNYFGGVTKIVVPDNLKSGVSKSHRYDPDINANYQHVSEHYGVAIVPARAAEPKDKAKVENAVGCIERQILAPLRHHTFTSIAEIKKAIAPKLVAFNKQSFQKMNTSRLELFEALDKPALQPLPSEPYHYAEWKRAKVNIDYHFVFDEHYYSVPYQYIHKTIEVRTSGSMVECFHEGKRIALHTRSKKRFTHTTLAEHMPSSHKAHAEWTPERIHRWALKTGEDTVRYIEYMIAARAFPEQAFRSCLGLMRLAQRFGADRLENACAIALEAGMTRYQQVERLLKNNMDLVRTSSKTTTPVIPHHNNLRGSNYYQ
>NZ_CP021257.1|WP_050598509.1|1635951_1636470_-|hypothetical-protein
MITTEILYIKNELIKRINACSTQSDSRLDLSSLDLDRLSIDGLIETMQKIPKSVTTLNLSDNGLYQLSTEHLAAALISIPKSVTTLNLSDNGFYQLSADRLAAALTSIPKSITTLNLSDNYLYYLGADDMAKALKGIPENVTTLNLSWNHLNKLSTDGLVIALTGLVYSGAK
>NZ_CP021257.1|WP_027227099.1|1637029_1639345_-|phosphoenolpyruvate-carboxylase
MKQDVSHLPRELSRMVFWSLTRLKKAIAEVYGKETYERIEQIRLSMQDTIGSESFALGKVLHNLQMELSKLDKKQLYQIAHGFSLMMELINTCENAYRIFRINQRKEQIYSDFPQGIHYVLTAHPTEARTNEFLKLFKEIRDYLVEVLKSPYLMNESHLDQMLKISLQINISYHEKPSVEDEAQYIYQYALHPLNIKLYHSFLEKGVPIQLRTWVGGDKDGHSGVNEKIMLKSLELSRSFFIAYIQECLKEVLGIIKLSTALNKNKFLADQIDQLVKKANGLKKIQPKDHEKVSAFKKELTAIQSNTLKFLNFEPEQFSIISSIFHLYPALVMPIELREDSAIVKESLTSIKKTTITKMLEQVHSITHGTDPKNYIRGFILSMVESAEDIKNGINLVKQVFKSYALPVVPLFENQLALTNADTILNDSITEDIRQKHLRQWDGNYEVMLGYSDSSKENGVLPSRLMIAKSLKNIQSTLENKNLRPIFFHGSGGSIERGGGDIKEQTASWSKEMMSNYKVTVQGEMVARLFGSSSILKSQIDKFLDIYSQKGKSNDNDYPEELSLFSTRVSQKYKTLIQSDWFWQIVEQASPYHFLKELKIGSRPTKRKSGPDQRKLRAIPWILCWTQTRLLFPTWWGIGSTWSELNGIEKNRLKALYKENALFAAFVKQLGVTLSKVYLPIWEQYLYQLTGSNEYLKPFQSELESTVLFFYQITGEKDFCFHQPWLGESIQLRSTLIHPLNLIQIEAMKRKDLPLLRKTVTGISCGMLTTG
>NZ_CP021257.1|WP_027227098.1|1639565_1640222_-|methyltransferase
MIDAVQNEPNIHFTYNYKQPDEYHFSLDSIHLAKFVAKQLKPYRDLGSLRVLDLCAGCGVIGIELSWHLQAIRQIDFIEIQDIYTEYFYQNIANVNRPELQLRWHLLNYDELHEKKWEGTFDLIISNPPYFQPGHGMLSPSKFKNRCRFYLDSSFQHYIRALENSLANKGRAYFLLRPLQQHGLDLFSDIQKVLQETSVTAKKISHIRGSDIILLEKR
>NZ_CP021257.1|WP_027221790.1|1640408_1640783_+|Y4oB-family-protein
MQTNTSSLQNIPDDVVWKSLTNLVERFDLKESEARILMGDMPRSTYTSHKAKLNRDQKERVSYLLGIYKSLRILFEDGEQARTWINRKNNLPPFNGLTPKEYMLEGGIVRLADVRKFLDFWRGY
>NZ_CP021257.1|WP_027227097.1|1640784_1641462_+|RES-family-NAD+-phosphorylase
MYSYIDFSEKVHRLIPSKFPPVTLFDWADSAEELEQIALLEGLTNERILAELGKINLIDKEDWIGGPGSTPIMAAFTHTGFESRFSDGSFGVYYAASSLETAIKETCFHRARFYSASNEKPCSISMREYVATIKKPLIDIRDKRYKELFNPDPAYYGKSQEFGKKVHEKKEWGLLYPSVRNLNGLCMAVLRPPALTLPRQGCHLRYIWDGEKISDVYKESKIANV
>NZ_CP021257.1|WP_027227096.1|1641572_1642997_-|hypothetical-protein
MIVIFVHGWSVTHTNTYGELPQWLENQSKQGKLDIQVGNVYLGRYISFDDTVTVDDIARAFDQALRDEIADKLRDGERFACITHSTGGPIVRKWMDLYFKNNLAKCPLSHFIMLAPANHGSALAQLGKSRLARIKSFFEGVEPGKYVLDWLELGSNMSWQLNESWLDYDCTANGIYCFVLTGQKIDRQLYDALNSYTGEAGSDGVVRVAATNMNYSLLKLHQEGDNGESLVVAKMTRTQPMAFGVLPGLSHSGKNIGIIRSITIANAATHPTAIWVLRCLQVKSRDSYNTLVQELDKITKETQKNEHTEFVKTLVFKREYITNRYSMIIFRLIDDRGNHLVDYDLYLTAGPQYSEQALPAGFFIDRQRNLNNRGKLTYFLDYDIMEGGINTPKMQGNLGFRVKAYPESSDQALAYYRLLDFHSSLADIHKILHPNETVMVEIMLQRRVDRTVFRITNNLAPAKISVKTTGKKVD
>NZ_CP021257.1|WP_027227095.1|1643821_1644886_+|hypothetical-protein
MWYDILLEYLGEKICPSNKEKARLLISQLLKLLKEDPDFGENFEPEFIFGVMVALYDYSTNHGNQNVSLDEFGKYCIGLIMVFSKISDDLSIYCSDFTYILSDKTILQELKIEGELATIRKDYLKKKRTNPEVTPFVDQKDVANPFEIYKKIGELAKIDLLKDLENRTLAYLNFSVKIQTEKIADMLNDLLNRVQNQQVIVSELYQYLLPYKGKDDLFDALIFSLKRELKKLSHNNFSPKTQPSSISKINLVLVPSLKIDQLPRHNPEIVNICEKLENYVFKGSSKKGSFFSAKNYCNHTKEVNEIVQKILKGDLLTIEAILDELAKINIENRKDELILLIKELQNERGCIRKL
>NZ_CP021257.1|WP_027227094.1|1645049_1646369_+|acetyl-CoA-C-acetyltransferase
MKHQSNLSGRNVYVVDGSRTPFLKAKGVGPFSGSDLAVAAGTTLLNRQPFSPDELDEVIIGSAMPGPDEANIARVIALRLGCGDKVPAFTVMRNCASGMQALDNAAIQIATGRSNLVLAGGTDAMSHAPLLFNEKMASWLANWFAAKSMGQKLALITKFKPSYLAPVIALLRGLTDPIVGLNMGQTAEKVAYRFGITREQMDEFATQSHLRIAKAYAENRMSEVAPIIDYKGCIYPQDDGIRADSTVEKLSKLKPFFDKKYGMVTPGNSSQITDGACLLLLASAEAVKKYALPVLGRIVDSQWAALDPSQMGLGPVHAATPILERHNLKPQDLDCWEINEAFAAQVLGCLAAWDDEEYCKTQLGLKEAIGAPSLERLNRDGGAIALGHPIGASGARIVLHVLKSLEQRNESRGMAAICIGGGQGGAMYLERVTEVKGHE

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP021257_2	2.1\|628296\|40\|NZ_CP021257\|CRISPRCasFinder	628296-628335	40	NZ_LR134418	Legionella adelaidensis strain NCTC12735 genome assembly, plasmid: 9	257659-257698	1	0.975
NZ_CP021257_1	1.9\|207181\|35\|NZ_CP021257\|CRISPRCasFinder,CRT,PILER-CR	207181-207215	35	JX094500	Cronobacter phage CR5, complete genome	89715-89749	8	0.771

1. spacer 2.1|628296|40|NZ_CP021257|CRISPRCasFinder matches to NZ_LR134418 (Legionella adelaidensis strain NCTC12735 genome assembly, plasmid: 9) position: , mismatch: 1, identity: 0.975

aataaatttattattgcatttttttgcattaattcaccat	CRISPR spacer
aataaatttattattgcatttatttgcattaattcaccat	Protospacer
********************* ******************

2. spacer 1.9|207181|35|NZ_CP021257|CRISPRCasFinder,CRT,PILER-CR matches to JX094500 (Cronobacter phage CR5, complete genome) position: , mismatch: 8, identity: 0.771

tcaagttgaaaatgccaaagaagccttaaaagacg	CRISPR spacer
aaaactggctaaagccaaagaagcgttaaaagacg	Protospacer
  ** * *  ** *********** **********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

216486 : 246233

Acidithiobacillus_phage(40.0%)

transposase,integrase

attL 216267:216326|attR 246394:248986

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
216267:216326	attL	NA	NA	NA	NA
WP_106331205.1\|216486_218001_+\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	1.0e-115	43.4
WP_028378828.1\|218012_218759_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	2.7e-64	50.4
WP_106331209.1\|218745_218940_-	hypothetical protein	NA	NA	NA	NA
WP_027228012.1\|219658_220174_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_032830280.1\|220563_220818_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_027228014.1\|220834_221062_-	hypothetical protein	NA	NA	NA	NA
WP_027228015.1\|222863_224495_-	murein biosynthesis integral membrane protein MurJ	NA	NA	NA	NA
WP_014843136.1\|224517_225435_-	carbon starvation induced protein CsiD	NA	NA	NA	NA
WP_027228017.1\|225436_225880_-	hypothetical protein	NA	NA	NA	NA
WP_014843134.1\|226094_226334_-	hypothetical protein	NA	NA	NA	NA
WP_027228018.1\|226708_227743_-	TfuA-like protein	NA	NA	NA	NA
WP_027223256.1\|227735_228797_-	YcaO-like family protein	NA	NA	NA	NA
WP_027228019.1\|228793_229816_-	ThiF family adenylyltransferase	A0A291ATS8	Pandoravirus	5.3e-07	31.4
WP_027228020.1\|229820_230072_-	MoaD/ThiS family protein	NA	NA	NA	NA
WP_027228021.1\|230219_231383_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_027228022.1\|231354_232617_-	hypothetical protein	NA	NA	NA	NA
WP_014843127.1\|232801_232996_+	hypothetical protein	NA	NA	NA	NA
WP_027223252.1\|233108_234563_-	MFS transporter	NA	NA	NA	NA
WP_028378789.1\|236186_236594_+\|integrase	tyrosine-type recombinase/integrase	I6PDJ1	Cronobacter_phage	6.3e-20	45.0
WP_080272285.1\|236772_237795_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	2.5e-81	46.8
WP_014844325.1\|237791_238586_+	AAA family ATPase	A0A2L1IVB6	Escherichia_phage	1.6e-75	53.9
WP_106228964.1\|238769_240197_+\|transposase	IS4 family transposase	Q9JMP3	Wolbachia_phage	1.3e-51	30.6
WP_027228136.1\|240698_242066_+	ATP-binding protein	NA	NA	NA	NA
WP_027228135.1\|242254_243460_-\|integrase	site-specific integrase	A0A1W6JTA0	Pseudomonas_phage	2.8e-92	48.6
WP_011214455.1\|243408_243615_-	hypothetical protein	NA	NA	NA	NA
WP_028378828.1\|243960_244707_-	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	2.7e-64	50.4
WP_106331205.1\|244718_246233_-\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	1.0e-115	43.4
246394:248986	attR	NA	NA	NA	NA

DBSCAN-SWA_2

573988 : 651935

Acidithiobacillus_phage(50.0%)

transposase,integrase,protease

attL 631936:631995|attR 649562:652155

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_106331205.1\|573988_575503_-\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	1.0e-115	43.4
WP_028378598.1\|576111_576939_+	Dot/Icm T4SS effector Lem24	NA	NA	NA	NA
WP_028378597.1\|577041_579039_-	patatin-like phospholipase family protein	M1I2P3	Paramecium_bursaria_Chlorella_virus	2.3e-06	26.0
WP_028378596.1\|579398_581096_+	diguanylate cyclase	NA	NA	NA	NA
WP_028378595.1\|581219_582041_-	DUF4116 domain-containing protein	NA	NA	NA	NA
WP_028378594.1\|582321_582981_-	hypothetical protein	NA	NA	NA	NA
WP_028378593.1\|583381_583642_+	hypothetical protein	NA	NA	NA	NA
WP_028378592.1\|583847_584945_-	hypothetical protein	NA	NA	NA	NA
WP_050598492.1\|585249_586371_+	hypothetical protein	NA	NA	NA	NA
WP_028378591.1\|586386_586788_-	NUDIX hydrolase	NA	NA	NA	NA
WP_028378590.1\|586775_587699_-	hypothetical protein	NA	NA	NA	NA
WP_028378589.1\|587995_589510_+	cytochrome P450	NA	NA	NA	NA
WP_027227441.1\|589641_590580_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_027227440.1\|590538_592053_-	serine hydrolase	NA	NA	NA	NA
WP_027227439.1\|592461_593817_+	YdgA family protein	NA	NA	NA	NA
WP_027227438.1\|594007_594583_+	acetyltransferase	NA	NA	NA	NA
WP_027227437.1\|594637_595837_+	M23 family metallopeptidase	NA	NA	NA	NA
WP_028378588.1\|596207_597278_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_027227435.1\|597405_597765_-	hypothetical protein	NA	NA	NA	NA
WP_027227434.1\|598064_598529_+	bacterioferritin	NA	NA	NA	NA
WP_027227433.1\|598661_599546_-	hypothetical protein	NA	NA	NA	NA
WP_027227432.1\|599813_601118_+	Dot/Icm T4SS effector SdbC	NA	NA	NA	NA
WP_027227431.1\|601159_602392_+	MFS transporter	NA	NA	NA	NA
WP_028378587.1\|604597_606763_-	catalase/peroxidase HPI	NA	NA	NA	NA
WP_032832017.1\|607093_608701_+	APC family permease	NA	NA	NA	NA
WP_027227428.1\|608828_609755_+\|protease	omptin family outer membrane protease Leo	NA	NA	NA	NA
WP_027227427.1\|609869_610433_-	hypothetical protein	NA	NA	NA	NA
WP_050598491.1\|610597_613336_-	cation-transporting P-type ATPase	M1HX51	Paramecium_bursaria_Chlorella_virus	4.4e-72	29.8
WP_027227426.1\|615518_617408_-	KUP/HAK/KT family potassium transporter	A7K9V6	Acanthocystis_turfacea_chlorella_virus	1.1e-74	31.3
WP_027227425.1\|617544_618453_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_027227424.1\|618820_620275_-	hypothetical protein	NA	NA	NA	NA
WP_027227423.1\|620436_621339_+	hypothetical protein	NA	NA	NA	NA
WP_027227422.1\|621882_622524_+	RsmD family RNA methyltransferase	NA	NA	NA	NA
WP_063720028.1\|622892_623249_-	hypothetical protein	NA	NA	NA	NA
WP_011214444.1\|623847_624015_+	DUF3309 domain-containing protein	NA	NA	NA	NA
WP_027227419.1\|624139_625327_+	fatty acid desaturase	NA	NA	NA	NA
WP_028378585.1\|625318_626482_-	hypothetical protein	NA	NA	NA	NA
WP_027227417.1\|626775_627714_-	lpg2370 family Dot/Icm T4SS effector	NA	NA	NA	NA
WP_027227416.1\|627710_628019_-	HipA N-terminal domain-containing protein	NA	NA	NA	NA
WP_027227415.1\|628015_628243_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_027227414.1\|628683_629601_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_027227413.1\|629790_630264_-	hypothetical protein	NA	NA	NA	NA
WP_031301595.1\|630570_630819_+	hypothetical protein	NA	NA	NA	NA
WP_027227411.1\|630834_631146_+	cupin	NA	NA	NA	NA
631936:631995	attL	NA	NA	NA	NA
WP_028378828.1\|632036_632783_-	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	2.7e-64	50.4
WP_106331205.1\|632794_634309_-\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	1.0e-115	43.4
WP_027227409.1\|635357_636263_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_027227408.1\|636302_636659_+	preprotein translocase	NA	NA	NA	NA
WP_032832101.1\|636693_637914_-	type II toxin-antitoxin system HipA family toxin	NA	NA	NA	NA
WP_027227407.1\|637900_638128_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_027227406.1\|638623_639646_+	hypothetical protein	NA	NA	NA	NA
WP_027227404.1\|640239_641028_-	hypothetical protein	NA	NA	NA	NA
WP_071974648.1\|641216_641405_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_027227403.1\|641466_642333_+\|transposase	transposase	NA	NA	NA	NA
WP_146077525.1\|642811_645298_+	hypothetical protein	NA	NA	NA	NA
WP_027227401.1\|646519_647749_+\|integrase	integrase family protein	A0A0P0IKP2	Acinetobacter_phage	1.5e-48	32.3
WP_027227400.1\|647812_648106_+	type II toxin-antitoxin system HigB family toxin	NA	NA	NA	NA
WP_027227399.1\|648102_648528_+	helix-turn-helix domain-containing protein	A0A0P0ZCT8	Stx2-converting_phage	9.9e-08	36.9
WP_028378828.1\|649662_650409_-	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	2.7e-64	50.4
WP_106331205.1\|650420_651935_-\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	1.0e-115	43.4
649562:652155	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1175420 : 1185536

Micromonas_pusilla_virus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_027229223.1\|1175420_1177355_+	molecular chaperone DnaK	G8DDB7	Micromonas_pusilla_virus	1.3e-147	49.6
WP_027229222.1\|1177542_1178682_+	molecular chaperone DnaJ	A0A1V0SBY2	Catovirus	1.6e-23	26.7
WP_027229221.1\|1178780_1179893_+	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	4.7e-49	34.4
WP_027229220.1\|1180095_1181244_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.7e-126	58.2
WP_028378862.1\|1181262_1182588_+	adenosylhomocysteinase	S4VPF6	Pandoravirus	6.2e-48	31.4
WP_027229218.1\|1182712_1183717_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_027229217.1\|1183853_1185536_+	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	6.1e-16	30.4

DBSCAN-SWA_4

2073908 : 2083404

Staphylococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_027227762.1\|2073908_2074733_-	3-deoxy-8-phosphooctulonate synthase	E3T537	Cafeteria_roenbergensis_virus	2.1e-54	44.3
WP_028378484.1\|2074729_2076367_-	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	3.2e-155	52.5
WP_050598205.1\|2076493_2076961_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	7.0e-23	49.1
WP_028378485.1\|2076968_2078177_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	4.1e-99	48.7
WP_028378486.1\|2078173_2078788_-	riboflavin synthase	A0A2I2L4R9	Orpheovirus	2.1e-22	38.4
WP_028378487.1\|2078772_2079846_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	1.8e-29	26.9
WP_028378488.1\|2079908_2081345_+	M48 family metallopeptidase	NA	NA	NA	NA
WP_011213531.1\|2081655_2081901_-	hypothetical protein	NA	NA	NA	NA
WP_028378489.1\|2082075_2083404_-	sigma-54-dependent Fis family transcriptional regulator	W8CYM9	Bacillus_phage	4.8e-08	31.1

DBSCAN-SWA_5

2351326 : 2358209

Acinetobacter_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_028377931.1\|2351326_2352124_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.0e-21	33.8
WP_027227555.1\|2352534_2353497_+	KpsF/GutQ family sugar-phosphate isomerase	A0A2P0VNK5	Tetraselmis_virus	4.2e-38	32.3
WP_027227554.1\|2353510_2354038_+	3-deoxy-manno-octulosonate-8-phosphatase KdsC	A0A140XBD6	Dickeya_phage	2.4e-27	47.7
WP_028377930.1\|2354034_2354604_+	LPS export ABC transporter periplasmic protein LptC	NA	NA	NA	NA
WP_027227552.1\|2354584_2355094_+	lipopolysaccharide transport periplasmic protein LptA	NA	NA	NA	NA
WP_027221199.1\|2355090_2355816_+	LPS export ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.1e-18	25.1
WP_028377929.1\|2355849_2356428_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	1.1e-54	52.6
WP_027227550.1\|2356405_2357440_+	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	1.4e-76	48.2
WP_028377928.1\|2357432_2358209_+	indole-3-glycerol phosphate synthase TrpC	A0A0P0IR83	Acinetobacter_phage	8.6e-58	48.6

DBSCAN-SWA_6

3115113 : 3121821

Acidithiobacillus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_028378322.1\|3115113_3115536_+	single-stranded DNA-binding protein	A0A077SK05	Escherichia_phage	6.2e-18	39.8
WP_106331223.1\|3115572_3117000_-\|transposase	IS4 family transposase	Q9JMP3	Wolbachia_phage	4.9e-51	30.4
WP_028378821.1\|3117127_3117634_+	antirestriction protein ArdA	G9FHQ1	Rhodococcus_virus	1.0e-19	35.6
WP_027229142.1\|3117851_3118298_+	SocA family protein	I6R0L8	Salmonella_phage	3.8e-42	54.4
WP_050598505.1\|3118393_3118711_+	hypothetical protein	NA	NA	NA	NA
WP_106331205.1\|3119548_3121063_+\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	1.0e-115	43.4
WP_028378828.1\|3121074_3121821_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	2.7e-64	50.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP021257

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection