CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP021555	Bifidobacterium breve strain 082W48 chromosome, complete genome	4 crisprs	cas3,c2c9_V-U4,WYL	0	3	1	0

1. NZ_CP021555

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021555_1

• CRISPR_ID: NZ_CP021555_1
• CRISPR_location: 149557-149893
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 6 spacers

Consensus repeat of NZ_CP021555_1

Consensus_repeat	Method
TACTGGTGGTTTTGCCCCGCTGAGG	CRISPRCasFinder

spacers of NZ_CP021555_1

>1.1|149582|27|NZ_CP021555|CRISPRCasFinder
CGTTGTTAGCGGTGCTTTTTTACCAGC
>1.2|149634|27|NZ_CP021555|CRISPRCasFinder
AGCTGTCAGCGGTGCAAAACTTCCAGT
>1.3|149686|27|NZ_CP021555|CRISPRCasFinder
ATTAGTAAGCGGTGTAGAGCTGCCAGC
>1.4|149738|27|NZ_CP021555|CRISPRCasFinder
GGTTGTGGATGGTGCGGAGCCCCCATG
>1.5|149790|27|NZ_CP021555|CRISPRCasFinder
AGCTGTCAGTGGCACGAAGTTTCCAGT
>1.6|149842|27|NZ_CP021555|CRISPRCasFinder
GGTGCTGAGCAACGCTTTTATGCCAAT

CRISPR arrays and Neighbor proteins around NZ_CP021555_1

CRISPR arrays

The CRISPR arrays of NZ_CP021555_1

>merge|NZ_CP021555|1|149557-149893|CRISPRCasFinder
TACTGGTGGTTTTGCTCCGCTGGTGCGTTGTTAGCGGTGCTTTTTTACCAGCTCTTGGCGGGATAGCTCCGTTGAGGAGCTGTCAGCGGTGCAAAACTTCCAGTTATTGGTAGTCTGGCCTCATTGAGTATTAGTAAGCGGTGTAGAGCTGCCAGCTACTGGTGGTTTTGCCCCGCTGAGGGGTTGTGGATGGTGCGGAGCCCCCATGTACTGGTGGTTTTGCCCCGCTGAGGAGCTGTCAGTGGCACGAAGTTTCCAGTTACTGGTGGTTTTGCGTCGTTGAGGGGTGCTGAGCAACGCTTTTATGCCAATTGCTGGCGATTTTGCGCCGCACAGG

>NZ_CP021555|1|1|149557-149893|CRISPRCasFinder
TACTGGTGGTTTTGCTCCGCTGGTG	CGTTGTTAGCGGTGCTTTTTTACCAGC
TCTTGGCGGGATAGCTCCGTTGAGG	AGCTGTCAGCGGTGCAAAACTTCCAGT
TATTGGTAGTCTGGCCTCATTGAGT	ATTAGTAAGCGGTGTAGAGCTGCCAGC
TACTGGTGGTTTTGCCCCGCTGAGG	GGTTGTGGATGGTGCGGAGCCCCCATG
TACTGGTGGTTTTGCCCCGCTGAGG	AGCTGTCAGTGGCACGAAGTTTCCAGT
TACTGGTGGTTTTGCGTCGTTGAGG	GGTGCTGAGCAACGCTTTTATGCCAAT
TGCTGGCGATTTTGCGCCGCACAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021555.1|WP_003832420.1|163144_164176_-|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP021555.1|WP_016462059.1|138537_139824_+|adenylosuccinate-synthase	unknown	unknown	gnl|CDD|234904
NZ_CP021555.1|WP_025341500.1|143328_144414_+|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380514
NZ_CP021555.1|WP_115775863.1|141567_142659_+|CrcB-family-protein	unknown	unknown	gnl|CDD|376809
NZ_CP021555.1|WP_106622142.1|137302_138370_+|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl|CDD|236406
NZ_CP021555.1|WP_015438246.1|155971_157093_+|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP021555.1|WP_106622146.1|153399_154404_+|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP021555.1|WP_014483285.1|150315_151683_+|MHS-family-MFS-transporter	unknown	unknown	gnl|CDD|340927
NZ_CP021555.1|WP_050824532.1|158154_159555_+|beta-glucosidase	unknown	unknown	gnl|CDD|274539
NZ_CP021555.1|WP_003827968.1|152077_153130_+|ketol-acid-reductoisomerase	unknown	unknown	gnl|CDD|235491
NZ_CP021555.1|WP_015438243.1|146571_148206_+|MFS-transporter	unknown	unknown	gnl|CDD|349949
NZ_CP021555.1|WP_023658006.1|143097_143256_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_015438247.1|157100_158048_+|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_CP021555.1|WP_106622144.1|141986_143054_+|CrcB-family-protein	unknown	unknown	gnl|CDD|376809
NZ_CP021555.1|WP_106622461.1|165083_169496_+|hypothetical-protein	unknown	unknown	gnl|CDD|380024
NZ_CP021555.1|WP_106622147.1|161058_162873_-|glycoside-hydrolase-family-13-protein	unknown	unknown	gnl|CDD|200471
NZ_CP021555.1|WP_003832411.1|159819_160872_+|ketol-acid-reductoisomerase	unknown	unknown	gnl|CDD|235491
NZ_CP021555.1|WP_106622143.1|139847_141431_+|ClC-family-H(+)/Cl(-)-exchange-transporter	unknown	unknown	gnl|CDD|238504
NZ_CP021555.1|WP_003827964.1|144840_146367_+|sucrose-phosphorylase	unknown	unknown	gnl|CDD|237528
NZ_CP021555.1|WP_106622145.1|148275_149328_+|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380514

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP021555.1|WP_016462059.1|138537_139824_+|adenylosuccinate-synthase	gnl|CDD|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NZ_CP021555.1|WP_025341500.1|143328_144414_+|LacI-family-transcriptional-regulator	gnl|CDD|380514	cd06291, PBP1_Qymf-like, ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs. This group includes the ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus metalliredigens (strain Qymf) and its close homologs. Qymf is a strict anaerobe that could be grown in the presence of borax and its cells are straight rods that produce endospores. This group is a member of the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.0934e-78
NZ_CP021555.1|WP_115775863.1|141567_142659_+|CrcB-family-protein	gnl|CDD|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	2.20639e-22
NZ_CP021555.1|WP_106622142.1|137302_138370_+|class-II-fructose-bisphosphate-aldolase	gnl|CDD|236406	PRK09197, PRK09197, fructose-bisphosphate aldolase; Provisional.	0
NZ_CP021555.1|WP_015438246.1|155971_157093_+|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	6.8801e-72
NZ_CP021555.1|WP_106622146.1|153399_154404_+|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.20554e-90
NZ_CP021555.1|WP_014483285.1|150315_151683_+|MHS-family-MFS-transporter	gnl|CDD|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.74298e-176
NZ_CP021555.1|WP_050824532.1|158154_159555_+|beta-glucosidase	gnl|CDD|274539	TIGR03356, BGL, beta-galactosidase.	0
NZ_CP021555.1|WP_003827968.1|152077_153130_+|ketol-acid-reductoisomerase	gnl|CDD|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NZ_CP021555.1|WP_015438243.1|146571_148206_+|MFS-transporter	gnl|CDD|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	1.33917e-14
NZ_CP021555.1|WP_003832420.1|163144_164176_-|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.72239e-78
NZ_CP021555.1|WP_015438247.1|157100_158048_+|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.05843e-66
NZ_CP021555.1|WP_106622144.1|141986_143054_+|CrcB-family-protein	gnl|CDD|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	1.07274e-24
NZ_CP021555.1|WP_106622461.1|165083_169496_+|hypothetical-protein	gnl|CDD|380024	pfam17802, SpaA, Prealbumin-like fold domain. This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.	1.26193e-11
NZ_CP021555.1|WP_106622147.1|161058_162873_-|glycoside-hydrolase-family-13-protein	gnl|CDD|200471	cd11332, AmyAc_OligoGlu_TS, Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomaltooligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. Trehalose synthase (EC 5.4.99.16) catalyzes the isomerization of maltose to produce trehalulose. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP021555.1|WP_003832411.1|159819_160872_+|ketol-acid-reductoisomerase	gnl|CDD|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NZ_CP021555.1|WP_106622143.1|139847_141431_+|ClC-family-H(+)/Cl(-)-exchange-transporter	gnl|CDD|238504	cd01031, EriC, ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked proton utilization. As shown for Escherichia coli EriC, these channels can counterbalance the electric current produced by the outwardly directed virtual proton pump linked to amino acid decarboxylation. The EriC proteins belong to the ClC superfamily of chloride ion channels, which share a unique double-barreled architecture and voltage-dependent gating mechanism. The voltage-dependent gating is conferred by the permeating anion itself, acting as the gating charge. In Escherichia coli EriC, a glutamate residue that protrudes into the pore is thought to participate in gating by binding to a Cl- ion site within the selectivity filter.	7.49223e-155
NZ_CP021555.1|WP_003827964.1|144840_146367_+|sucrose-phosphorylase	gnl|CDD|237528	PRK13840, PRK13840, sucrose phosphorylase; Provisional.	0
NZ_CP021555.1|WP_106622145.1|148275_149328_+|LacI-family-transcriptional-regulator	gnl|CDD|380514	cd06291, PBP1_Qymf-like, ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs. This group includes the ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus metalliredigens (strain Qymf) and its close homologs. Qymf is a strict anaerobe that could be grown in the presence of borax and its cells are straight rods that produce endospores. This group is a member of the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	7.41196e-76

Protein sequences

>NZ_CP021555.1|WP_106622145.1|148275_149328_+|LacI-family-transcriptional-regulator
MVGMRDVAKTAGVSLSTVSLVVNNTGYVSDDMRAKVEAAMRQLNYIPNELARNLYRNRTNTIGVIMPTIAHPFFATLTAHLQREFAARDLKTLLCSIADADKGEGEYVDMLQRHMMDGIVMAAHTEHPGGYWTSIHRPIVAFDRTLGEGVPAVRSNHEQGGRLIARQLIDSGARHVVLVGGPRSQFAEATTFPTIRYHLTVERMLADAGIACDYVEAGIVADICAHEATARAIFERYSDVDAIVGSDLVASVALQEALRRGISVPRDLQIIAYDGTFMAETAGMRLTAVRQDFPAVAAALASRMDSQIAADNGTTSAAAAEGGNAVAANGGQSTSEDIISVTLIPGETTR
>NZ_CP021555.1|WP_015438243.1|146571_148206_+|MFS-transporter
MLEPYVRPGIDDRPDLDKALSPEDKDAVARLAIKDRRRPPEASADQPEAQAVRLAAAGSSAAAAAAASVDAPAPDLSSAYLDMRDPMVAANGQRPTAVQISRLNWGFFVASILVGAPWAALNTIAMPNAVARLFDYDTASAISVTINPSTGRPLPVATDLVVPLAVLVVVGVVASMFAMPLVSALSDRTRIPLGRRTPWMVAGGVLCALITLVLGQNTGLVVLCFFWALMQFAYAMISVPLASAISERVPDKFRPRIERWHGIGVMLGQALGVCMGALGVMFDSFTPFAYTAVLFAVSGILTVIVLPKEPSSQEQPHQRFESSQVFDQLRPPAHAPAFARVFAARVCMMTGVGLTGVFLWYLVRFWVYGKAVVFTSAPLTIPAGLLIAGMAAATLIGAALASWAAGPISEKIEERNIATTAVVAASCLLYAIGVAVAWGLGVWSTGTARENGMLLFALISGFAFGVYDALGLELVMNALPDPRNAGHDLGIYALANSVGLALAAIIGAVLVSAFASSFGYYLLFPSAIVMVFLAGIITLSSKAE
>NZ_CP021555.1|WP_003827964.1|144840_146367_+|sucrose-phosphorylase
MKNKVQLIAYADRLGDGTLSSMTDILRTRFDGVYDGVHVLPFFTPFDGADAGFDPIDHTKVDPRLGSWDDVAELSKTHGIMVDAIVNHMSWESAQFQDVLKNGEHSEYYPMFLTMSSVFPNGATEEDLAGIYRPRPGLPFTHYKFAGKTRLVWVSFTPQQVDIDTDSAKGWEYLMSIFDQMAASHVRYIRLDAVGYGAKEAGTSCFMTPKTFKLISRLREEGVKRGLEILIEVHSYYKKQVEIASKVDRVYDFALPPLLLHSLFTGHVEPVVHWTEIRPNNAVTVLDTHDGIGVIDIGSDQLDRSLKGLVPDEDVDNLVNTIHANTHGESQAATGAAASNLDLYQVNSTYYSALGCNDQHYLAARAVQFFLPGVPQVYYVGALAGRNDMELLRKTNNGRDINRHYYSTAEIDENLERPVVKALNALAKFRNELPAFNGEFSYEADGDTSITFRWIAADGKTKAALIFEPGRGLGTDNTTPVASLAWTDAAGDHETDDLLSNPPIADID
>NZ_CP021555.1|WP_025341500.1|143328_144414_+|LacI-family-transcriptional-regulator
MVGMRDVAKKAGVSLSTVSLVVNGNGYVSDDMRERVRKAMQLLNYVPNELARNLYHNRTNLVGVIVPTIRHPFFATFTAHLQHALAAQGLRTMLCSTADEADGEIQYVDMLRRHMMDGIVMCAHTSHPGDYWTSIHRPIVAFDRVLGDGISSIGSDHEQGGRLIAQMLIRNGAKHVVMIGGPRDQFFDLAARGEVEEGPFDLGKTTFPTVRYCLTLEQELTSAGVKYEYVEAGEVMDFAGYHRAVSNALDKVTTDGVDAVVSSDIGASFCVREALSRGISIPDELQIVAYDGTYLTDLAGMKLTAVAQDFSAIAQSTADHIVQAIANEEVAAANASRRDIPKPFEPNVLIPMTLVPGDTTR
>NZ_CP021555.1|WP_023658006.1|143097_143256_+|hypothetical-protein
MSATAIKAASPDATLVIAFDQTKPLLKAFASAGVDTKKLYFVAGLSNRFERM
>NZ_CP021555.1|WP_106622144.1|141986_143054_+|CrcB-family-protein
MAASPGAAGCQPWRWARLARRAFDDVRRDAGNDGRSARAAYRQCAWLSCGKFCRRFAHCRRRRGSDAGTAVTEYSKAGSGCVFSCFRVRFCRIGHAGRTPCESGRRGAFCRAGRNGSRADGPADCTDGTGSASRNANRAADCHPAYADRPRSADSSAGRSSAGTVIAAVVARAGYSRLGAAARADSAVAADPAAGQPASAQLRAQTDHCGDFACRRPGYRGGALMMWMICLFGGLGAMARYVLDVSIQRGWNRENRRTNRNFPLSTLVINGVASLCAGIAMMSYYSQSVDMDTVMMFVVGFLGGFSTFSTALNEVVSLIRQRRFTLALGYGIATVAVPLICVAAGFGIALLANPA
>NZ_CP021555.1|WP_115775863.1|141567_142659_+|CrcB-family-protein
MGGNNAVRGRPVQGSAMESQEQSPGDVVTAGEDSHPITQAIDTVEVTHAGATAPAANTMDPPTIPLAPMKRMQARFNPLADGLMYVVVFVGGFVGVGCRHALDMLLPSVSGTPFVVGTFVSNMVACFLFAMLTEFMATASWLRRRVRQVVSRGVGLGLLGGLSTMSGVMLETMAGLHERHIASALGYLAGNFAGGLLTAAAGVVLMQALLSRSTRKRVRGAFSAVSVSDSAESDTQGVRHVKVADVARSAAQAAMEAAQTAQQIAQTGQVPRVETPTVPPTAIQPMQTGHVPQIPPLVVPQLAQSSQPLLREPDTPDLGQLPEPIQQSQPIQQPANPLPPSFEPKPITAEISLVADLATGEVR
>NZ_CP021555.1|WP_106622143.1|139847_141431_+|ClC-family-H(+)/Cl(-)-exchange-transporter
MTGNDAAHDIRRLIPRFDHLKWKMAAAGIVIGLVSGLLVVVYRLGIEYGTDASRWIYARIRETPWLIAPWAVAAVAAALAIAWMVGKEPMAGGSGIPQTNGVVICGLKMRWQTILPVRFVGGLLGALFGLSLGREGPSIQIGASGAQCVSHRLRGRRREDMQEHYLVTAGAAAGLSAAFSAPLSGMMFALEGVHRSFSPAILMGATAASLTADFVSKYCFGLRPVLDFGDIGQLSLEEYVWLIPLGLVAGLVGSLMNRSLLGFQTLYCKLPAWSRPMIAIAIALPVGIWLPDVLGGGSNLIDTAEHARVGLGMLCLLFVAKMLFTSTSFGSGAPGGIFMPILAVGSLAGGICGEVLHRFGNLPSDAVAVFAVCVMTGTLAASVKTPITSILLAVEMSGTLTHMLPVAAVAFIALLVSDLLRTKPIYGELLERYVRAQGMQMAIASHVGSGIMELPLEMGAIADGKRVRDVRWPSGCLIIGLRRGESEIVPRGDTRLRAGDYLVVLFSGEEEREVRPAMRRLCDARLD
>NZ_CP021555.1|WP_016462059.1|138537_139824_+|adenylosuccinate-synthase
MPGIVLIGAQWGDEGKGKATDLIGTKVDYVARFNGGNNAGHSVVVGDESYALHLLPSGIINPNLTPVIGNGVVVDPEVLFEEIDGLESRGIDCSHLLVSEAAHIIAPYHRTLDKVTERFLGKHKIGTTGRGIGPAYADKINRIGIRVHDLFNADHLHDKVEASLHQKNQMLVKLYNRRAIDVDQTTDELLKLGERLKPYVANTGLILNKALDEGKTVLFEGAQATMLDVDHGTYPFVTSSNPTAGGACTGTGVGPTKITRVIGVAKAYVTRVGEGPFPTELLDESGEWLRQQGHEFGVTTGRPRRCGWFDAVVNRYASQVNGLTDIVLTKLDVLTGLKEIPICVAYDVDGERHDDMPTDQAEFAAAKPIYESMPGWDEDISQIHDFNDLPKTCQDYVKRLEDLSGCRISAIGTGPQRDHVIQINSLVD
>NZ_CP021555.1|WP_106622142.1|137302_138370_+|class-II-fructose-bisphosphate-aldolase
MTIATPERYAEMLDAARRGGYAYPAINVSSSQTLNAALKGFADAESDGIIQVSVGAAAYLSGIGVNDRVTGSLALAAFAHEVAAKYPNITIALHTDHCAKQYLDEWVRPLLAHEADQVAHGQEPTFQSHMWDGSTVPLKENLDIAEELLDKSQAAHTVLEIEIGAVGGEEDGYSAKIDERLYSTPADGLEVARRLGLGEHGRYMAAFTFGNVHGSYKPGVVKLRPALLGDIQSRVARAVVEGELPSAAGIVDFPNGKPFELVFHGGSGSRPEEIAEAVSHGVIKMNIDTDTQYSFTRPIADHVFENYDKVLKIDGEVGEKKFYDPRSWGRKAEESMSARVAEACKQLGSAGKALR
>NZ_CP021555.1|WP_014483285.1|150315_151683_+|MHS-family-MFS-transporter
MTAAVEETGLGQAASKATAMVRDSVKTVIAASMVGTAIEFYDFYAYGTAAANYFPHIFFSDKANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTYTLFYTLATWSLAWGTKDTANGGGNLGFNNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGQVVGQRNFFANMVFLCVGFALMGIAFGPIGAFLPELFDANVRYSGSGIGYNLAAIVGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLVSVLTCKETKDVDFTK
>NZ_CP021555.1|WP_003827968.1|152077_153130_+|ketol-acid-reductoisomerase
MAATIWYEKDADLSVFDGKKVAILGYGSQGHAHALNLRDSGVDVVVGLRPSSKSVEFAKEQGLEVKPVGEAVAEADVVMILLPDQYQAKVYEEEVEPNLKPGAALAFAHGFNIHYGYIKPSEDHPVFMVAPKGPGHIVRREYAAGRGVPVVVAVEQDPDGKTWPLCLAYAKALGALRAGAIKTTFTEETETDLFGEQDVLMGGINHLCDLGFDVLTEAGYQPEIAYFEVFHELKMLVDLANEGGLNKARWSCSDTAQYGDYTSTVITDETKKRMQYQLKRIQDGSFAKEFMDDQAAGAPKFKKLQEEFSHPHLETVGPKLRAMFSWNNAEAKDKDEAESFNGKIARTQVQ
>NZ_CP021555.1|WP_106622146.1|153399_154404_+|LacI-family-transcriptional-regulator
MANGQKATIRDVAKRAGVAVSTASRALSHGSASKATREKVFCAAGELNFVPNPAARQLMSGRSNIVAIAIPEHTDFIFRDMFVAGILGELSRAFSERRMLPFLALTELQDTESLERLLRDSSADGVVVLSFHYSRQLAQVFHDFDKPTVFIGRPFPRMRYPYVDVDNEGAAYCAAELLVERGRRNIGIIAGPDDMMAPKQRTMGCVNGLADQGMKPLAVISGEYTAEHGFEACERILEQYPEVDGVFAQSDQIAVGVLQALAKHGRQVPNDVSVIGFDDFPVATMTNPKLTTFAQPLHDMAQVIAEMLCWRLEHGEWNTVAQVLPASLIKRDSV
>NZ_CP021555.1|WP_015438246.1|155971_157093_+|sugar-ABC-transporter-permease
MTARQSHGQAKSKQDWHSRLEMFEWKASPYLYIAPFFILFLIVGLFPLLYTMWIATRQFNTLTGDAGFAVCGSTCGTTNASWFGNFMWVLHQPTFYVALRNSVSIFLLSSVPQIIIALWLAWVLDANLKAKTFWRMGVLLPYIVAPSAAGIIFSQVFSDKMGAINVLLQQIGMQPIMWHGNTFWSHVAIATIVNWRYIGYNTLILLAAMQAIPRDVLEAAVVDGAGKWRTFRSVTLPMLRPTLIFVIITSTIGGLQIFDEPQMFHNGASAGGGANNQYLTVSLYLYKLGFVSVTPGQPNLGRAAAVAWILFLIVVAISLLNYALTQRLATGGQSRESKEAARLSAQRDEAERQKAIRTGVNGRMDAQQVAERK
>NZ_CP021555.1|WP_015438247.1|157100_158048_+|carbohydrate-ABC-transporter-permease
MVDLTNESDKREVGVPALEQVYGKSVARAAKRQRNARLGMTSEGRKPGWGSYAILIVTLLIFVFPLYYALSIASQNTPSNQYGVRALIPGTALLHNLSRALGELKFWQALGGTVTVAVVVSVSTVFFSTLAGYSFAKLHFRGRSVLLTAVVATMTIPQQLTVVPLYIMANKAGLYGNLLAVIIPGLVSAFGVFWMTQYITDALPYELIEAARVDGCSMFRTFISVGVPAARPAASMLFLFTFIGQWTNYFWPMLVLGANKSYMLTTAAAALKGAYFTDYTIVMSGVILTTAPLLLLFFVAGKQLVAGIMAGAVKG
>NZ_CP021555.1|WP_050824532.1|158154_159555_+|beta-glucosidase
MTFVFPKNFTWGVATASYQVEGAIHEDGRAPSIWDAFCAVPGAIEDHSSGEVACDEYHRYPEDITLLKELGVNAYRLSIAWPRIVPLADGKVNSKGVEHYIKVLDALRDAGIRPVVTLYHWDLPQYLEDQGGWANRDTALRYGDYVHALAEAFGDRVDTWTTLNEPWCAAYLGYGNGIHAPGVRDYGKALSAVHHLNLAHGLGALAVHDTLGERAKVSVTLNLSACVAQSDSEADRMAKHRNDLLSNEVFLGPMLDGAYDPEIFDVTTDYTDWSFIRDDDLKTIRQPVQCLGINYYSSTHVKGVTDPAECERRRNDHMQAVPAQDIVDALPPEGELTDMGWNQEPRVLTEMLVGLAKRYPGLDLMVTENGSAWKDEVTEDSSAPGGRIIHDPKRVAYLNHHIRAIADAIEAGVPVVGYFAWSLLDNFEWAFGYSKRFGIIGVDYETQKRIWKDSAYRYRQIIQEGI
>NZ_CP021555.1|WP_003832411.1|159819_160872_+|ketol-acid-reductoisomerase
MAAQIWYENDGDLSVLEGKKVAIIGYGSQGHAHALNLRDSGVDVVVGLRPTSKSVDFAKEQGLEVKSVAEASAEADVIMILAPDQYQRTIWANDIEPNIKPGAAVAFAHGFNIHYGYIKPTEDHPVFMVAPKGPGHIVRREYAAGRGVPVVVAVEQDPRGDGWALTLAYAKALGALRAGAIKTTFKEETETDLFGEQNVLMGGVNKLVEMGFEVLTDAGYQPEIAYFEVCHELKMLVDLMNEGGLNKARWSCSDTAQYGDYTNTVINEDCRKRMEYHLQRIQDGSFAKEFIDDQDAGAPHFKELQEKYSNERIETVGPKLRAMFSWNKDGVKDADEANSFTGKIARAQVQ
>NZ_CP021555.1|WP_106622147.1|161058_162873_-|glycoside-hydrolase-family-13-protein
MTANNLNDDWWKQAVVYQIYPRSFKDVNGDGIGDIAGVTEKMDYLKNLGVDAIWLSPFYPSDLADGGYDVIDYRNVDPRLGTMDDFDTMAKAAHEAGIKVIVDIVPNHTADKHVFFKEALAAEPGSPARDRYIFRDGRGEHGELPPNDWQSFFGGPAWARVADGQWYLHLFDKAQPDVNWKNPDIHEEFKKTLRFWSGHGTDGFRIDVAHGLAKDLESKPLEELGREYSVVGVLNHDFSHPLFDRREVHDIYREWRKVFNEYDPPRFAVAEAWVVPEHQHLYASMDELGQSFNFDFAQASWYADEFREAIDAGLKAAAETGGSTTTWVMNNHDVPRSPSRYGLPQVKGAPYHQLPHDWLLRNGTTYPEDRELGTRRARAAALMELGLPGAAYIYQGEELGLFEVADIPWDRLEDPTAFHTAQATMDKGRDGCRVPIPWTAANEPTLADFSRPIPADDGTGENHVPLCAAGQFGTGASFGFSPAVRADGVTSSADPHLPQPLWFKDYAVDVEQADPDSMLALYHAALAIRQESLTATRDTTAEQVDMGPDVVAYTRAAVGGSTFTSITNFGTEPVELPGGSVVLTSGPLTPDGQLPTDTSAWVIQ
>NZ_CP021555.1|WP_003832420.1|163144_164176_-|LacI-family-transcriptional-regulator
MAKASIQAVAKEAGVSVSTVSRTFAKPDLVLPETRDKVMAAAEKLDYSISRSAAALKSGQSFRIALLASETITTWFNANIFAGLDSVLRPAGYDTVAYPMRNAEERHDFFADLPVRRNADAVIVSSFNIEPAEVERLKHMHVPIIGINIPSTDGFDSGVSIDDRTATRAAVEHLIALGHRGIAFVGGTPAETNMRYSAESRLQGVLDAQAAHPELTVTNLQVPRGATETSAALNAVLTAPAGTTAFCFEDDELALPVLYRLRQYGKRVPQDISIVGFDDVEMSQAVGLTTMHQDPFAMGADAGRMALEAIAGGPIEPAFIQPDAPLVLRETTAPPAAPVPAQG
>NZ_CP021555.1|WP_106622461.1|165083_169496_+|hypothetical-protein
MGTEANPATERDSGVATWVGGDMYVGKKSDNLTNADGPDASYSAEAEGLTVVNGKLMLHPQKNSWNGQGFRFGVAGFGTQYRPAEGSTALVVGGNTGTVMDSATSTADVKAWNKPGFIDGHSHVGSLSGSQSDVWGRDGTSSIGSYNGASVNWQKDKSGNTQNQDAGNLTKVSVKATDGAAATDKDFSKDTFYQGYVVDDIVSPLAKQNKTGTVSSSISPLSELPRHKYNYYKEGTNAASGISYTFKYDDTTKYGTGRGIAPTTPYTNREKLITFTGTNNASMEVFNLDASMLSDTDENGTLYRGVGFAFTNIADTASVVINVTGNASNISFHNGWQFWWNGAEISDGYSNYNNTDELKKKSAAYDKASQKILWNFSNTDNLTIYGGVANEDGTNTNADKITQDDAAAAMMGSIIVRGNFESHVSTNGRVYTGGDFSMYNPYKAWTFNQAGANDGDSASVLDMDQERHNFPWNGSYTESCSAIAWQKADESGTLLGGTTWAVYGKYDDAASGKNALLTVQDNAFYDKDSADGRFTVEGLKPNATYYIKEVSAGNDYQLNTNVYYVATGDSSATPVDVTRSVTKTDGAYTYGKADMTDGKIVNKKNGHEVSWSKVDADTNKELAGSQWQIQQVKDGAATKSWNVTDNTSKATGVTVNPTSATLDSTNGWKTDLTAAVDPKDALQEVAWTFTDKDGNAVDSSTVAVLTRTGNLKTTVTGISSIDTTVYVKACSVSNPEVCSALVTIKVKAMSVKDFTVKDSSNRTVENNSTITAAAVDSTLTFTASSTPAVPITWESSNKSVATVTSSGENGQKATVTMTGFGSAVITAKAGDKKVSFTVKVPSTTVYFKKSLMNWSKYYVYYNAGNNNWKFVEMSQSCGDYVYAILPKQSPGTDFLFHGDDENTSTNKWYQGSNKSDFKFTGNEVQVVNQYNDSQVSTAPAGCPASAAAAAQSNDAAVLNENAVVTPADDPQPSDADGVAENAIDDGAKAISCTAADGENGRPGVKCDMDTAAGKFKVGGLDAGTYWLHETTAPDGYTINKTLYQFTIDANGNVTWNGGWASGEATGAIDEKLKPGDNNAISDTPTEVTWNKVDTKGGKLAGSQWKIVGPSPAMDVYCVADNVTVDANGATTPAGIEFTGCTGEKLSDAANTADEAGVITVRGLPVGTYTLTETKAPDGYVATTTVYTLTISDTEASTVVAQTATDRPTTRSGGNREAAANVPNASAPVNIQIPVKKSVKYTSWPKDSNGNYVNFNFKIEATKSTVDANPAAPMPAECSSSDATKNDCTISLAPKSDADDLSNVIAKFGKMTFTDANLAAAAGDASDYAKTYTYKITEIVPDSADAVENLRYSKAEYQVVVTVKQAKDSSGKLSGLSVSATMTRIKDDSGNAEAGGGKMIGTWSSTSTGSSAGTAVEATFVNTKVLTGLPTTGADWTGRLVLLVGDGFILAGVLIAGGYQLAKRRREEDSD

Crispr_ID: NZ_CP021555_2

• CRISPR_ID: NZ_CP021555_2
• CRISPR_location: 450942-451246
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of NZ_CP021555_2

Consensus_repeat	Method
CGTCCGCGTCGCCGTCGCTCCGA	CRISPRCasFinder

spacers of NZ_CP021555_2

>2.1|450965|34|NZ_CP021555|CRISPRCasFinder
CCGTGACGATCGCGACTTCGACGATCGCGACGAC
>2.2|451022|25|NZ_CP021555|CRISPRCasFinder
CGATTTCGAGGATGACTACGAGGAT
>2.3|451070|46|NZ_CP021555|CRISPRCasFinder
TGATCGCGACTTCGACCGTGACGACCGCGATTCCCGCGATGATGAT
>2.4|451139|25|NZ_CP021555|CRISPRCasFinder
CGATTTCGAGGATGACTACGAGGAT
>2.5|451187|37|NZ_CP021555|CRISPRCasFinder
TGACCGTGGCGATCGTGATGACCGCCGTGGTTCTCGT

CRISPR arrays and Neighbor proteins around NZ_CP021555_2

CRISPR arrays

The CRISPR arrays of NZ_CP021555_2

>merge|NZ_CP021555|2|450942-451246|CRISPRCasFinder
GGTGGCCGTGGCCGCCGCTCCGACCGTGACGATCGCGACTTCGACGATCGCGACGACCGTCCGCGTCGCCGTCGCTCCGACGATTTCGAGGATGACTACGAGGATCGTCCGCGTCGCCGTCGCTCCGATGATCGCGACTTCGACCGTGACGACCGCGATTCCCGCGATGATGATCGTCCGCGTCGCCGTCGCTCCGACGATTTCGAGGATGACTACGAGGATCGTCCGCGTCGCCGTCGTTCCGATGACCGTGGCGATCGTGATGACCGCCGTGGTTCTCGTGGTGGCCGTGGCCGTGGCTCCGA

>NZ_CP021555|2|2|450942-451246|CRISPRCasFinder
GGTGGCCGTGGCCGCCGCTCCGA	CCGTGACGATCGCGACTTCGACGATCGCGACGAC
CGTCCGCGTCGCCGTCGCTCCGA	CGATTTCGAGGATGACTACGAGGAT
CGTCCGCGTCGCCGTCGCTCCGA	TGATCGCGACTTCGACCGTGACGACCGCGATTCCCGCGATGATGAT
CGTCCGCGTCGCCGTCGCTCCGA	CGATTTCGAGGATGACTACGAGGAT
CGTCCGCGTCGCCGTCGTTCCGA	TGACCGTGGCGATCGTGATGACCGCCGTGGTTCTCGT
GGTGGCCGTGGCCGTGGCTCCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021555.1|WP_003828242.1|462505_462979_-|30S-ribosomal-protein-S16	unknown	unknown	gnl|CDD|184724
NZ_CP021555.1|WP_025262747.1|443884_445432_+|isopeptide-forming-domain-containing-fimbrial-protein	unknown	unknown	gnl|CDD|380024
NZ_CP021555.1|WP_025299550.1|452646_453549_-|hypothetical-protein	unknown	unknown	gnl|CDD|380149
NZ_CP021555.1|WP_019727801.1|437546_438245_-|transporter	unknown	unknown	gnl|CDD|223551
NZ_CP021555.1|WP_157824037.1|432643_433198_+|transposase	unknown	unknown	gnl|CDD|290319
NZ_CP021555.1|WP_003828229.1|448110_448380_+|30S-ribosomal-protein-S15	unknown	unknown	gnl|CDD|180170
NZ_CP021555.1|WP_106622190.1|435568_436105_-|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl|CDD|223427
NZ_CP021555.1|WP_106622470.1|436427_436862_+|holo-ACP-synthase	unknown	unknown	gnl|CDD|234610
NZ_CP021555.1|WP_052792399.1|456909_457152_+|hypothetical-protein	unknown	unknown	gnl|CDD|378333
NZ_CP021555.1|WP_025262755.1|459351_460215_+|aldo/keto-reductase	unknown	unknown	gnl|CDD|381314
NZ_CP021555.1|WP_003828240.1|461611_462226_-|ribosome-maturation-factor-RimM	unknown	unknown	gnl|CDD|234650
NZ_CP021555.1|WP_014483444.1|433210_433876_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP021555.1|WP_106622194.1|454654_456910_+|DUF2207-domain-containing-protein	unknown	unknown	gnl|CDD|378333
NZ_CP021555.1|WP_003828239.1|460482_461538_+|nucleoside-hydrolase	unknown	unknown	gnl|CDD|239116
NZ_CP021555.1|WP_003831475.1|447294_447981_+|teichoic-acid-transporter	unknown	unknown	unknown
NZ_CP021555.1|WP_003828241.1|462248_462482_-|RNA-binding-protein	unknown	unknown	gnl|CDD|179479
NZ_CP021555.1|WP_106622191.1|439948_443677_+|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|377553
NZ_CP021555.1|WP_106621377.1|433947_435285_-|DUF2974-domain-containing-protein	unknown	unknown	gnl|CDD|371412
NZ_CP021555.1|WP_016462228.1|454010_454589_+|LemA-family-protein	unknown	unknown	gnl|CDD|377192
NZ_CP021555.1|WP_106622193.1|451801_452512_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213222

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP021555.1|WP_003828242.1|462505_462979_-|30S-ribosomal-protein-S16	gnl|CDD|184724	PRK14520, rpsP, 30S ribosomal protein S16; Provisional.	3.01239e-64
NZ_CP021555.1|WP_106622191.1|439948_443677_+|VWA-domain-containing-protein	gnl|CDD|377553	pfam05738, Cna_B, Cna protein B-type domain. This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.	1.59042e-09
NZ_CP021555.1|WP_157824037.1|432643_433198_+|transposase	gnl|CDD|290319	pfam13586, DDE_Tnp_1_2, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.02886e-09
NZ_CP021555.1|WP_052792399.1|456909_457152_+|hypothetical-protein	gnl|CDD|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	0.00239717
NZ_CP021555.1|WP_025299550.1|452646_453549_-|hypothetical-protein	gnl|CDD|380149	NF012181, MSCRAMM_SdrD, MSCRAMM family adhesin SdrD. Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.	0.00038069
NZ_CP021555.1|WP_003828240.1|461611_462226_-|ribosome-maturation-factor-RimM	gnl|CDD|234650	PRK00122, rimM, 16S rRNA-processing protein RimM; Provisional.	2.4629e-48
NZ_CP021555.1|WP_003828229.1|448110_448380_+|30S-ribosomal-protein-S15	gnl|CDD|180170	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed.	1.16189e-53
NZ_CP021555.1|WP_025262747.1|443884_445432_+|isopeptide-forming-domain-containing-fimbrial-protein	gnl|CDD|380024	pfam17802, SpaA, Prealbumin-like fold domain. This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.	1.03224e-09
NZ_CP021555.1|WP_106622470.1|436427_436862_+|holo-ACP-synthase	gnl|CDD|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	3.51058e-24
NZ_CP021555.1|WP_106622190.1|435568_436105_-|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl|CDD|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	7.36759e-44
NZ_CP021555.1|WP_025262755.1|459351_460215_+|aldo/keto-reductase	gnl|CDD|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	9.92055e-89
NZ_CP021555.1|WP_014483444.1|433210_433876_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.1451e-06
NZ_CP021555.1|WP_106622194.1|454654_456910_+|DUF2207-domain-containing-protein	gnl|CDD|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	4.67189e-81
NZ_CP021555.1|WP_003828239.1|460482_461538_+|nucleoside-hydrolase	gnl|CDD|239116	cd02650, nuc_hydro_CaPnhB, NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. .	2.56495e-132
NZ_CP021555.1|WP_003828241.1|462248_462482_-|RNA-binding-protein	gnl|CDD|179479	PRK02821, PRK02821, RNA-binding protein.	8.71349e-36
NZ_CP021555.1|WP_019727801.1|437546_438245_-|transporter	gnl|CDD|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	3.86809e-07
NZ_CP021555.1|WP_106621377.1|433947_435285_-|DUF2974-domain-containing-protein	gnl|CDD|371412	pfam11187, DUF2974, Protein of unknown function (DUF2974). This bacterial family of proteins has no known function.	9.38205e-117
NZ_CP021555.1|WP_016462228.1|454010_454589_+|LemA-family-protein	gnl|CDD|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	1.44236e-78
NZ_CP021555.1|WP_106622193.1|451801_452512_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.90017e-80

Protein sequences

>NZ_CP021555.1|WP_003828229.1|448110_448380_+|30S-ribosomal-protein-S15
MALTAEEKTQIINEYATHEGDTGSPEVQVALLSKRIADLTDHLKEHKHDHHSRRGMQLMIGDRRRLLDYLKRVDINRYRSLIERLGLRR
>NZ_CP021555.1|WP_003831475.1|447294_447981_+|teichoic-acid-transporter
MEQEPNEQEPNEATEIVGSKVETVEVSKHPEASIPETDLSLADIERRRSHPVRWAVTILAVLAAIIAPYWLGRSFAVNNTEAVVAALGDVSAQGIALVGWTVVVIAYVGLVMAIVVSPSWPWLIVFVVGLAAEQFIAGLSMLNLHFWYSTYVVYGEQSNIANAANLGILAAAIGVAVYAVIFVGLLVVIKKTSPLNVLTKSWASFILYFVIEGVALFVVLFGGLLTAV
>NZ_CP021555.1|WP_025262747.1|443884_445432_+|isopeptide-forming-domain-containing-fimbrial-protein
MKLRKLFAGVAAAATLLGGMAFGATAANAADTASITLSGKTVKGTVYTAYKIGSYDTASAKVEKDKLASVGVTTDQAWKTDAENVLGSTVTNTPEYKGYGDPLAYVAGTTGYYTNTPATLPNASATMESFVQSLAGKLDGKTAVDPSQTVANDNDKVVFSGLDEGLYLIVSKTDTEPATDAGSPLAIVGTQVTVNGTAYTKLGANNQTLGKAVVKPSTPQKPSKSASDLNPYVGATITYTLEGTVPAKANSFKFVDTPSAGLTVKLDTLKVNVQGETDPLANTEYTVDPASGDFNTSAAKPSFTIALNNATKYQGKHIVVKYNALVNKKANVNGTNNDVRFDNSNQTTTTTITPQLNTVTFTKKGVDADTNALKGVVFQIVADTNNATPLPDGTATEATSGDKGVVTFSGLPNGTYTITEKTPADGYLTTALPSFTVTVENGKVTNVTPTGVGAGLVTFENGYANIVVKNVKKITQLPLTGAAGTMLFTVVAVLLAGVAATVFAKSRFTKRALDA
>NZ_CP021555.1|WP_106622191.1|439948_443677_+|VWA-domain-containing-protein
MKRIAEWFAAVGAAASKSGKRLVAVVAAVAMLGGVAGVSATAMADDQSAADTQQSTAQTETPANTDSKDAGTDTGNKDDSTKADATKSDDAASADTDAAASELTEQTAPAPTSTLNTQAAEATNGSCVYAGNVASGLNNVCWLDMTNFTADKDQLQPMSVKLSDSLTMKFNIKYTGGRKLRSAAVPTWNKAAFGHYGYAGFPEGTKPALYQITGSYNTESTVELTDIKIVNADGSEITGNYSFMMADAESTNNDESISFTSSNEIEQVAQFPQQGDANYKNYAFGDQTFSADHKTVTGGGVRTGANPGIYLYKTKSPDTVSVTMGVHYGREIQAAIFGVLFSNAETTVTTNNASDTFAGKVESQTYGSEQTGGVTGSNSATSKVVNMLSDTDTSEQVKFTLSASENTNWNDYNVSFTCDGDCGEYDATPQIDTATGNRYVTVSVASEKSAHGKWVVTKKVKLDTPKIQKSISKDEVDSAATGQKDSYTLSLNVKGNTVSGTTTSGEKAKIDVAFVLDTSGSMNDKVGNSTRLKNMQNAITDNGGLSSVLFNSPDKIDAQAHVITFASGLGLDGTSVLSTKADLDEVVNGLTANGATHWEKGLERVSNISTRPGATKYVVFLTYGDPGNKGWKETNVYSCGVLGLQTCDDNDSARSVYNASVIAGKQLAKAGWNILNVGVDMPTTVYVNPEADSVSGSNHKLHNHSFSPTAGWVSPLEALTARENDNKSTTVKDQLIKAYPKTTSSELAQVFKDLGQIITTTTTKSYGKVSIVDTLSDYADPLFEYDKQSGEITSGVTVVTSDRSNVDAEVASKTYDVATRTVTVTFRDGFTLAKDVTYSVQFKVKPSDKAYETYASNKQSEKGGYTDTDNTVHQGETGTGTDSENKDGFYSNAEAHLAYSECTAVNNVAKDCVSKDNVTYQKPVLQVKTGKIQVTKKWDPTDSEPKDGSKVTVNIYKGDHADDGQKVDTLTLAKDGGWTGSLGNLAPGTYFVEETNVDGYTASYSQSQTVTITADDLWKAEPNMTKFDNVKTYDVTITNTLNRVDLDVNANVKVSKTVQGAAASKDFTFNLTCAKSNAACKDGVTWPKDSNGSLTATASKSDLQTIGTPADAKFPDGSTLQLKAPTGTTSAVYEFTVSEDQSGNPAGWKYDTDTVTVKVTVSKKTDGSGYKTNVEYVYADGDSDKTDNPKSADFTNVFVAVSSLPVTGGRSARDWLIYGGGLGLLALLAGAGYTVWRKRQLV
>NZ_CP021555.1|WP_019727801.1|437546_438245_-|transporter
MTYDLVSLSIIMMIAVACPIITQLIPGKPMPQTVLLLVFGAIFGPFILDKIWVTKAVELLSELGLAFLFLLDVVLGAFAAGFILRFITPNGNHTLNLKLEGVGYGFLIPVFFVVSSTSIDVKAVVANPALLITFIIMLLLVRAVPIFAATTLDHRVNPLDPQDKLTVSLYCTTALPLIVAVTSLAVQGGTMHQTTASTLVAAGAVTVFLMPLLGGLTSKLMKGETRLIAPTA
>NZ_CP021555.1|WP_106622470.1|436427_436862_+|holo-ACP-synthase
MGHDVVDVAAFAEQLGQPGSHMRALFSVREVRQAADRARQKNDGEAVHLAAKWAGKEAFLKAWCDFLESAPFPFTLDNFPWREIEILDDSRGVPHVSLSGDASPAFQTDYSGSIPDVHISLSHDGPVASAVVMIQSGNNSREIR
>NZ_CP021555.1|WP_106622190.1|435568_436105_-|methylated-DNA--[protein]-cysteine-S-methyltransferase
MRTIVETPIGRMIMASDGEALTELCLEDWWWAAKNQQHDNGTPDSELEVFRITRDWLQAYFADERPSLSQAPPMNPAGTPFQHEVWQLVAEIPYGMTASYGEIAAELSERRGGGRMAAQAVGGAVKHNPITIIVPCHRVVGSGRAFGGYGGRLDIKAELLEHEGVDMTRFDLPNIRLA
>NZ_CP021555.1|WP_106621377.1|433947_435285_-|DUF2974-domain-containing-protein
MTGIIDYARTELRPFSELPFNEIDALIIATLIYEDVANICPTLMLDEQQQSGSFATRIRAFEPEHPLIWLKGLWHPAMESISLEEANQELHRSIDTSEDDKPHEAQMVSVIDPHLTHTLFEEAGNNPRFAGIRLGAVVEHVNRGEQTQFAAATFQLPDGRNRRNPTHKGTMVLSFRGTDDSLIGWKEDFNMAFQYPVPAQRAASAYLDTVARLWDGPIVLVGHSKGGNLAIYAAMNADAKVQNRIRHIYSLDGPGFPSEIVTSPAYRRIQPKVTKIVPSSSIVGMIFETPEPCRVVSSDSDGIMQHSAFTWLVDGDQFVTEPDLSSSSQLFNEELNHWVGALTPEQRERAVDALFTVLHSNGATTFSEVMGNFPASIPSMLGAFVGLTPEDRRHLAEAVPILIKAATAKHKTDSANAKAAADADEPNGTPATEQKNEPNDKPINV
>NZ_CP021555.1|WP_014483444.1|433210_433876_-|TetR/AcrR-family-transcriptional-regulator
MPRPRHDSEVLPAKERLENAFWELLADRDYRKITVTDVVSEAGVNRNSFYYHFSGLPELADSAILHQVESIPINRTPDPNGNPEEQWRERITATLANPEQRQRLDRLALLAGPHSTLELTESLRDFCRLQMISMLQRDPEHLDLTTDLMIEFTVGGMLAVLQRWPKLSGTIEIKDLLKEDVAVLAMGIYLAMSREDMLDYWNRIFAHGPQNSNNTAAGHHN
>NZ_CP021555.1|WP_157824037.1|432643_433198_+|transposase
MESAAAWLASCFPIAVFLCLATENRTQDTGHAPIPSPNQSSQNLGRYPTEVHVVSDGESTVVEIHLSPGNEHDAAHGRRSMAALGASVGAHLLMGRAYEGDSTRLPAESFGLAPVVSPKRNRTAPWDYDREAHKGRNMVERVFNRMKHHRKAATRYDRLDATFLANLQLILIAVYLKNTAKNPT
>NZ_CP021555.1|WP_106622193.1|451801_452512_-|ATP-binding-cassette-domain-containing-protein
MNTAIETNTATIVEPTTEPALQLEHVSYSYSKGGKRVLIDKNYAFHPGTVVSITGPSGAGKTTLLSLLSGLTTPTKGRVLHNGEDLAKADRYRFRSHGIGVIFQSFNLLPALTVAENIILSVDASGKTFDRPKKQIAAELIEKVRLQPEYLNERILHLSDGEQQRVAIARALSYDPQIILADEPTGNLDLATQDDIMGIFKDLAHAEGKCVIIVTHSPEVAAQSDEVFQLAPLRER
>NZ_CP021555.1|WP_025299550.1|452646_453549_-|hypothetical-protein
MFVLNNAWKTVIRNKGRNILIVLIVAIIAAADTIGLAIRNAADNARETGLANTSVTATISVDRSKLMEQARESQSSDSSFGSSDSSDSSDSDSAPDFDAMRGALGSSNLTSADYQKYAKASSVSVSSCYSESTGVSGTDSFQPVETSTANAANSSDSSSDSGSSNQQGQGGPGGDMGGGPGGSGASGGNTSTGNGDSSSNSSGDSGSSSVDGSDSYNSESGSSGNDSSSGNGDSQGGQPGGMCGVMSQAVDYVSEINATVNLAVVGQLILIGLGLTLISALVGIVFVMRYEPLQILADRS
>NZ_CP021555.1|WP_016462228.1|454010_454589_+|LemA-family-protein
MSAGLIITIVVVVVIVALIAWAVGAYNNLVTLKNRVKNGWAQIDVQLKQRADLIPNLVNTVKGYATHESEVFTQVTAARAGVVAAANDPNATTAQRAAAENQLSRALVNLQATAEAYPQLQANQNFMDLQAQLKDLENKIAYARQFYNDVVLKLNTAIETVPTNIIAGLFHFEQAQYFEADDASRQAPQVKF
>NZ_CP021555.1|WP_106622194.1|454654_456910_+|DUF2207-domain-containing-protein
MKKRFIRAGVISALITFAVVCFAALMMVIMPAGDSADLSYRTLDYDVTATADGNLKVTQRIDVKLRDRSDDDGDRPWKQLFQQYSLAPGNLTDITDISVRNVTDGIDYAQQTEPKLPSAVSSNEAWNSDYANHWYIADVSASSDNPQPYTPGTDGIQVGESSKSAKTVEIGWNIPVTTEANSMKFEVSFTMHNVATKWQDVASFQWEPFGKKNQVPIGTVTGTVHFPEDITGKTSWAWLHTERTSETKRESDGSYTFTAYNIRTGDYLDVVAAFDSSKAGDMARTQPGDHLNDLKTSEYNQQQRWLDRQRLAARIRLIGWIATIVIGLALCVWGVWAAIASNRRAQYHGDIEYWRDQPGISPASAARLITLVDASATGSSSDRELTATMLSLAVKKAIAIYPGPADMYRGIDMSQATPVGLIQMITADPGKMNAARNTSTIVILPASLDAASNIEQLGLSQSEEALLALLITISQRVGCPVFDLNQMKNVCKDWASGYLELNKFTDSCAAEYSPLTSTASSQWAVAGVLAVVLGLGSLIVNGTTGFMVAGMITGSPLLLVGLFCLLGGTSTALTEPGHEMAGRCLGLKRYMQDFSNFADRGAADIAMWDWYMVYAAAFGISERVMKELAKAYPQVNDPAWLDANAAGTLFYWNYRPYGWYGGRYYGDSATADQGNLGAAGPVPAYGGISFAGGFSDLGSQLSAGFADISSTIQAAAPSSDSGGDFGSFGSGGGSGFGGSFGGSGGGSFGGR
>NZ_CP021555.1|WP_052792399.1|456909_457152_+|hypothetical-protein
MSHRTIHSIIATLIAAATITAILIVTLLIFNWFTADHPKRSYRSLDYEVAVQPNGDLKVTQHIDMKLDSRGKNKPWKQLY
>NZ_CP021555.1|WP_025262755.1|459351_460215_+|aldo/keto-reductase
MTLFRQLGPFSTTAIGHGEMPLTIENNRGHEVGIETLHASLDAGCRHIDTAWAYYCSGGEEQTGEKLVREALETWKGPKDEVLVATKVGHFRNFTDDRPTWDVDGRPENLIRRGKESALALGVDTIDLLYFHRPDPKVPYSESVEAIKQLVDEGVAREAGISNASIEQIDIARGILGDKLVAVQNQYSPIHLHTQDTLDYCAKVGLAFVCWSPLGGYRHPYDETKFDPFREVAAAHGVSYQQVVLAWELAKGDHMFVIPGAHHPETILDSLKADQLELTPEELAKLG
>NZ_CP021555.1|WP_003828239.1|460482_461538_+|nucleoside-hydrolase
MRKKLILDLDTGIDDALAIAYALGSAGDADLIGITATYGNVAVPLAARNALAVLHAFGRDDIPVYPGIDHPIAPAKLPLMRGTTPDERAEAYRRWQEGGEDGWQTDTPWSPSPGSVAVHHPNGIGGAVLPDSPRQPEAPGSAVDFIIAAARECGPDLTIVPTGAMTTMATVFRNAPDLKDSGINVTLMGGSLTLPGNVSPAAEANISQDPEAADYLFKCGARTTMIGLDVTHQTALTREKAHEWAALGTPAGDFLVTMTDYYIDFYVKNQPEIHGCGLHDPLAVAAALDPSLVTTFGFNLQVDLEGPFRGRTIGDRSRVQDPDKHTQVALGVNVPAFLDRFMQRVTAVVRG
>NZ_CP021555.1|WP_003828240.1|461611_462226_-|ribosome-maturation-factor-RimM
MAEQDMHDDPQQLELLRVARIGRAQGLKGEVTVRLYTDDPEWRFEPDSVLYSQDGETEYIVENSRTFKDRWILKLEGTDDRTAAEALNGVELYGEADDAEEMLEADEWYPKDLIGLEARLSEGNGLGLPAGQVVGKVVDVVDSPAQSLLKIRLVEPVVTGQDSKGEDVIEKTALVPFVEALVPEIDLDEQYLTLDPPGGLIPGL
>NZ_CP021555.1|WP_003828241.1|462248_462482_-|RNA-binding-protein
MLAQAVEHLIKNIVDFPDDVSVKSHENARGELLRVRVNPEDIGRVIGRSGRTANAIRTVVQALSDHKVRVDIMDVRR
>NZ_CP021555.1|WP_003828242.1|462505_462979_-|30S-ribosomal-protein-S16
MATKIRLKRQGKKFYAFYRVVVVDSRKKRDGKVIEEIGTYNPNTQPSTIQIKSDRAQYWLGVGAQPSEPVFKLLNITGDWQKFKGLDGAEGTLKTVEAGPDAEARIAAVENQAQKLKAAKSEADAKAKAEAEAAAAAEETPAEEAPAEAAEEAPAEA

Crispr_ID: NZ_CP021555_3

• CRISPR_ID: NZ_CP021555_3
• CRISPR_location: 1221832-1221933
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP021555_3

Consensus_repeat	Method
GTTTGCTTCGGTTTTGCTTCATGGTTTGCTT	CRISPRCasFinder

spacers of NZ_CP021555_3

>3.1|1221863|40|NZ_CP021555|CRISPRCasFinder
CGTCTTTTGCTTCATGGTTTGCTTCGGTTTTTGCTTCATG

CRISPR arrays and Neighbor proteins around NZ_CP021555_3

CRISPR arrays

The CRISPR arrays of NZ_CP021555_3

>merge|NZ_CP021555|3|1221832-1221933|CRISPRCasFinder
GTTTGCTTCGGTTTTGCTTCATGGTTTGCTTCGTCTTTTGCTTCATGGTTTGCTTCGGTTTTTGCTTCATGGTTTGCTTCGGTTTTGCTTCGTGGTTTGCTT

>NZ_CP021555|3|3|1221832-1221933|CRISPRCasFinder
GTTTGCTTCGGTTTTGCTTCATGGTTTGCTT	CGTCTTTTGCTTCATGGTTTGCTTCGGTTTTTGCTTCATG
GTTTGCTTCGGTTTTGCTTCGTGGTTTGCTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021555.1|WP_106622312.1|1224886_1225156_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_106622309.1|1222346_1223765_-|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|275105
NZ_CP021555.1|WP_032734780.1|1216054_1216591_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_106622306.1|1219978_1220566_-|hypothetical-protein	unknown	unknown	gnl|CDD|99838
NZ_CP021555.1|WP_106622307.1|1220796_1221201_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_106622305.1|1219644_1219839_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_032746516.1|1220562_1220772_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_106622310.1|1223897_1224299_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_016462991.1|1214937_1216062_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_060618548.1|1226643_1227261_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_157825985.1|1226021_1226477_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_052829184.1|1225170_1225434_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_016462985.1|1218934_1219219_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_008783515.1|1227468_1227723_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NZ_CP021555.1|WP_016462983.1|1219331_1219652_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_016462971.1|1225689_1225935_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_106622304.1|1217905_1218682_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP021555.1|WP_106622311.1|1224308_1224884_-|single-stranded-DNA-binding-protein	unknown	unknown	gnl|CDD|236092
NZ_CP021555.1|WP_016462966.1|1227837_1228251_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_CP021555.1|WP_106622303.1|1217647_1217851_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP021555.1|WP_016462966.1|1227837_1228251_+|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.54397e-05
NZ_CP021555.1|WP_106622309.1|1222346_1223765_-|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	1.24424e-34
NZ_CP021555.1|WP_106622311.1|1224308_1224884_-|single-stranded-DNA-binding-protein	gnl|CDD|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	4.60669e-82
NZ_CP021555.1|WP_106622306.1|1219978_1220566_-|hypothetical-protein	gnl|CDD|99838	cd06135, Orn, DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins. Oligoribonuclease (Orn) is a DEDDh-type DnaQ-like 3'-5' exoribonuclease that is responsible for degrading small oligoribonucleotides to mononucleotides. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. Orn is essential for Escherichia coli survival. The human homolog, also called Sfn (small fragment nuclease), is able to hydrolyze short single-stranded RNA and DNA oligomers. It plays a role in cellular nucleotide recycling.	8.56284e-26
NZ_CP021555.1|WP_008783515.1|1227468_1227723_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.58489e-07

Protein sequences

>NZ_CP021555.1|WP_106622307.1|1220796_1221201_-|hypothetical-protein
MSDQPTAATLRLVEGRENNRCIVCDRYLRGGEWPGSSHHHRKRRSQTYGDPERHSPSNVIDVCGTDNSTGCHGWIHRHPEQARALGYLLKSYDPEPSTVPVYSVRRGWILLDTDGQWHSCPPPEGMPNHPQTNR
>NZ_CP021555.1|WP_032746516.1|1220562_1220772_-|hypothetical-protein
MNAYAVTVPGELDNVDFTREDGTSVTMLIPPDIPVSTRTIIIPQGFTREETRTIQGAIVQALAGKEKTL
>NZ_CP021555.1|WP_106622306.1|1219978_1220566_-|hypothetical-protein
MIPEKPEALLWMDVETTGLDANMCSILEIGLRCTSLDAMHEYGRFEAVVHIGRETLLTVQPSALELHLNNGLLAQCESCDPLANSPRVIAEQALRFIQGMATTYTLHPAGTNISRFDLPMVERFCMTGFGELLHYRMLDVTALRLAAKACGQDPYQHRMKPTHRVHDCLDRDINEYRHYLTLMTPPALAAKEDRS
>NZ_CP021555.1|WP_106622305.1|1219644_1219839_-|hypothetical-protein
MSCTARIWTQDQLEQALASACVLEGVSILHRFQQADKDRRNLKAVVKTMYETTGMPTIVEDDDE
>NZ_CP021555.1|WP_016462983.1|1219331_1219652_-|hypothetical-protein
MSDLTQQALTALADAGLGNESAAEAFVLGYQAGYDAALTLAISIETHINSNEPTDEEIETCARGFFQGTPGPTNWDDCSEVSKQAWLHAAKKALAAVNAMKTKEQQ
>NZ_CP021555.1|WP_016462985.1|1218934_1219219_-|hypothetical-protein
MNVSESIDWRHAKPWELDLHRFIAITNSGQTLDGWLKYFPRAYGYWTIQDSDFFTDIFRPDPIDKTISLYTGAFKSINVLKETRKPCKERTAES
>NZ_CP021555.1|WP_106622304.1|1217905_1218682_-|hypothetical-protein
MNCQNCKTITEEGYSLCESCELRFAGTLLRLARDVTPLHDSLDATLHPGGHSPTRIQTATPPTPIRLDVLDLIDMLDATARELWRCLDGIDALDWRKDKRNEDLKATLIACAGHPRLATFADAGFYMHVVDGIARKVDAALDPPEQRREIGTCELCETMLTAGAADQWVTCPVCGREQRAQTVKLRRLKTLCWDDSRRGSAAEIAKVFTDAGITVKRHTLTVWKSRGKLDVTPQGISYSSVYRLVISGGLDKELTVTA
>NZ_CP021555.1|WP_106622303.1|1217647_1217851_+|hypothetical-protein
MATEYLGVKQVAERLGITSGGLLNLKLPEPDATIGRTRGWLPETIDEWNAQRPGRGVGVGRPRKNKA
>NZ_CP021555.1|WP_032734780.1|1216054_1216591_-|hypothetical-protein
MNIMPSGGKRVRSGPAKDPNSEKSRRLGYTLQSLPNTECRMKPPEWPLEPADDERVRELEAEKWGWLWKLPQARAWHLPQFKWMIHELALYARLSTACEIAPAPTALTVLLRISDRVGMSAAGLQALGWKIEAEAERKPVDSEFTRRRAKELNRESAAERSPMDETRHVYQRRMSGNG
>NZ_CP021555.1|WP_016462991.1|1214937_1216062_-|hypothetical-protein
MADEDSWLIDFPTLGHLVCAWIERHCRQPDGPLRGRPVVLSDWQYWLAANRWRIREDAPYVPPEEVTVDNPMVLNQAFEYRMTLTVGPQKWGKGPCTAFFTAAEGCGPTIFDGWAREGDVYRCADNGCPCGWEWPYNPGEPKGRRHPSPLIQLTANSEEQVRNIYRPLVATILLGPLKELMRVRDTFIRILQPGREGEADALDLDRIDVVTASAKSRLGNPITDAEQDEAGLYTKSNGMIAVATTQRRGAAGMGGRTHAWTNAWDPGEDSYAQQVFENAEDDVFVFYRNPDLAKSLRHRDGRPLDFNLKSERLKMLEYVYRGSPWVDLNSIESEAKALMKTDPTQAERFFGNRLVQGGGAWLEDGLWESCYADA
>NZ_CP021555.1|WP_106622309.1|1222346_1223765_-|ParB/RepB/Spo0J-family-partition-protein
MSINIIDINVTNLIPNPNNPRRDVGDVTELADSIREQGLQQALVVTPDHEEHGERLFRVVIGHRRLAACKLAGIERVPCIVRELDAKTERELMLVENCQRSDLTPLEEADGYQGLLDLGANVGELASKTGRSESFVRGRLRIARIPAEVRSGSKGFAQFSLSQLDELAEFEDHPDMMRELASQAGSNNWAWKANQLRQRLKDEAWRVAVRAVLRELHVVVEEPESGSVWSVPDGCLFCDVFHGRPEDLADWWKQWRVKHPTDGPVVRVADTTVYAFPRMSAAQIAERDARDAARERENALAEERLDRRKRFEHDATQLRLVWIREHATRFNGGQLRKANTRLSLLVLTGTDGYSGLIASRRWDNDERVLDAYNALTTPLPVIEDGDVELYCEQNLTELHRRQNVEGAANRELLLILCAQMEAIIDHSTWADKDDITIAQAYYQALEDLGYPISDEENKALKGEYLPEDDEAE
>NZ_CP021555.1|WP_106622310.1|1223897_1224299_-|hypothetical-protein
MPRKKKTDGVQDALIPDEITPLMLLALTAKASRMKDAAAAFRIAASKMLDLATKDEYIEKYKNIDPITDALYDACDLSQHIFDAANAVNDLINYPVEARERVVKADIERSLLDPWRDLPTGGVDPKTGEIKED
>NZ_CP021555.1|WP_106622311.1|1224308_1224884_-|single-stranded-DNA-binding-protein
MAGETVITIVGNLTADPELRTIASGAVVCGFTIASTPRIWNRQTNQYEDGQALFLRCSAWRDLANHCAQSLSKGMRVIATGRLQQRSYQAQDGTNRTVIDMTIDEIGPSLRYATAQVTRTQSGRGYSGGSTYGDPAKPANQQQGWQNGSPASAQNPGMQEGDQWAQPAPASLGAAFDASDDFQSNDSDPEF
>NZ_CP021555.1|WP_106622312.1|1224886_1225156_-|hypothetical-protein
MTSQPDDYDYREEGESLFEWPLDAAGMRMGTGELLDSLLEVIQHLNRADAWPLTILPPRFGDVVVDRGRRTISAVCLWKRKPSNDSKEV
>NZ_CP021555.1|WP_052829184.1|1225170_1225434_-|hypothetical-protein
MSAMIPPDVIQDGVAYWKADKVSAYFGGSPTVGTLGVWRYRGEGPRFVKLGGKREHRQRDTRRVVYPVREVIAWGERNGLQQQTVAA
>NZ_CP021555.1|WP_016462971.1|1225689_1225935_-|hypothetical-protein
MNAKDYGRHASGFRTADGGPSKRFMRRLVFWGVVFAACLAWVMTHEACRYPLANGVCSLVAFLGVPLRLLCLVASEAGADE
>NZ_CP021555.1|WP_157825985.1|1226021_1226477_+|hypothetical-protein
MNWTEPSVLVAIAALLWNCVQQRQINKIRRSDRIAAQHLVATLDSESLRCIHFRNEGTMTLYRPKVDSDFFLSSGIPIANAEICLNIPPNTEAVFSLTNASDIPRLPDFLRIQWIEWTRLKKRTHYMSVSMVEVKRAYVERVRSHEGQARS
>NZ_CP021555.1|WP_060618548.1|1226643_1227261_+|hypothetical-protein
MMVTWLWNLIQGDFAQNPTAWMDLAITVLGIVLSPVAWFTSKCLEGKAAKREAKDAQEKFDAQLEVLKGQLKAANDSADALRAQVKTVEDSADALRGQLAAQRTQARLAEETASVPKWDIYQVQNLKYAVANENAFDAHDVRVVLSSGKEYELGNISKGSSIGFMFMEKAIMCEDGYADIRITWSLPGESGERHSVTKPSPQYLH
>NZ_CP021555.1|WP_008783515.1|1227468_1227723_-|helix-turn-helix-transcriptional-regulator
MSNVNAWVGNRVDEKIREKGMTKRFVSEKSGMPYSSLNSKLKGYRGFDLDDILALAEAIGESPSELLPPQFTKDVPALAEGEVK
>NZ_CP021555.1|WP_016462966.1|1227837_1228251_+|helix-turn-helix-domain-containing-protein
MSKIQDERSHRFSQLIGLELKASFARHETSQADVAEKLGHSKSGYSRWLNAKPSMPMEALINTCELLGVDPREVFNAAYRRLIEEMGECKTALAGERLVDDEQARIDETLKKLHRGDMDIVALEDEHKYDGDGDEPA

Crispr_ID: NZ_CP021555_4

• CRISPR_ID: NZ_CP021555_4
• CRISPR_location: 2180140-2180216
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP021555_4

Consensus_repeat	Method
GCAAATCCCCCAACCAATCGAAGAA	CRISPRCasFinder

spacers of NZ_CP021555_4

>4.1|2180165|27|NZ_CP021555|CRISPRCasFinder
CCACCCCGTCCACGGACCCTCAACGGG

CRISPR arrays and Neighbor proteins around NZ_CP021555_4

CRISPR arrays

The CRISPR arrays of NZ_CP021555_4

>merge|NZ_CP021555|4|2180140-2180216|CRISPRCasFinder
GCAAATCCCCCAACCAATCGAAGAACCACCCCGTCCACGGACCCTCAACGGGGCAAATCCCCCAACCAACCGAAGAA

>NZ_CP021555|4|4|2180140-2180216|CRISPRCasFinder
GCAAATCCCCCAACCAATCGAAGAA	CCACCCCGTCCACGGACCCTCAACGGG
GCAAATCCCCCAACCAACCGAAGAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021555.1|WP_106622492.1|2187666_2188365_-|histidine-phosphatase-family-protein	unknown	unknown	gnl|CDD|366010
NZ_CP021555.1|WP_021648767.1|2189857_2192605_+|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl|CDD|224428
NZ_CP021555.1|WP_025341952.1|2173618_2175142_-|amino-acid-permease	unknown	unknown	gnl|CDD|224038
NZ_CP021555.1|WP_015439324.1|2181870_2182476_-|DUF624-domain-containing-protein	unknown	unknown	gnl|CDD|377412
NZ_CP021555.1|WP_015439323.1|2180346_2181819_+|amino-acid-permease	unknown	unknown	gnl|CDD|224038
NZ_CP021555.1|WP_003829602.1|2182626_2183469_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_CP021555.1|WP_103619685.1|2175394_2179153_-|FtsX-like-permease-family-protein	unknown	unknown	gnl|CDD|274008
NZ_CP021555.1|WP_042994364.1|2168158_2169988_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP021555.1|WP_106622447.1|2185917_2187246_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|379175
NZ_CP021555.1|WP_014484409.1|2183468_2184323_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP021555.1|WP_042994362.1|2167208_2168150_+|FAD:protein-FMN-transferase	unknown	unknown	gnl|CDD|376782
NZ_CP021555.1|WP_015439311.1|2165685_2167104_-|hypothetical-protein	unknown	unknown	gnl|CDD|340890
NZ_CP021555.1|WP_106622446.1|2184693_2185710_+|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP021555.1|WP_103619680.1|2164006_2165056_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl|CDD|223390
NZ_CP021555.1|WP_052788289.1|2170119_2171988_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP021555.1|WP_050825218.1|2172171_2172693_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP021555.1|WP_014484412.1|2188451_2188829_+|DUF4235-domain-containing-protein	unknown	unknown	gnl|CDD|379422
NZ_CP021555.1|WP_003829607.1|2179162_2179864_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222
NZ_CP021555.1|WP_052788286.1|2192601_2194941_+|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl|CDD|224428
NZ_CP021555.1|WP_100218455.1|2163617_2163887_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP021555.1|WP_021648767.1|2189857_2192605_+|YhgE/Pip-domain-containing-protein	gnl|CDD|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	2.95062e-89
NZ_CP021555.1|WP_025341952.1|2173618_2175142_-|amino-acid-permease	gnl|CDD|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	2.17319e-154
NZ_CP021555.1|WP_015439324.1|2181870_2182476_-|DUF624-domain-containing-protein	gnl|CDD|377412	pfam04854, DUF624, Protein of unknown function, DUF624. This family includes several uncharacterized bacterial proteins.	1.2616e-07
NZ_CP021555.1|WP_015439323.1|2180346_2181819_+|amino-acid-permease	gnl|CDD|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_CP021555.1|WP_003829602.1|2182626_2183469_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.68174e-62
NZ_CP021555.1|WP_103619685.1|2175394_2179153_-|FtsX-like-permease-family-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	4.51797e-20
NZ_CP021555.1|WP_042994364.1|2168158_2169988_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.74447e-179
NZ_CP021555.1|WP_106622447.1|2185917_2187246_-|ABC-transporter-substrate-binding-protein	gnl|CDD|379175	pfam13416, SBP_bac_8, Bacterial extracellular solute-binding protein. This family includes bacterial extracellular solute-binding proteins.	3.47244e-34
NZ_CP021555.1|WP_014484409.1|2183468_2184323_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.2199e-52
NZ_CP021555.1|WP_042994362.1|2167208_2168150_+|FAD:protein-FMN-transferase	gnl|CDD|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	5.09687e-23
NZ_CP021555.1|WP_015439311.1|2165685_2167104_-|hypothetical-protein	gnl|CDD|340890	cd17332, MFS_MelB_like, Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily. This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.54925e-45
NZ_CP021555.1|WP_106622446.1|2184693_2185710_+|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.76783e-77
NZ_CP021555.1|WP_103619680.1|2164006_2165056_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl|CDD|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	4.41629e-106
NZ_CP021555.1|WP_052788289.1|2170119_2171988_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	7.33136e-142
NZ_CP021555.1|WP_050825218.1|2172171_2172693_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.527e-14
NZ_CP021555.1|WP_014484412.1|2188451_2188829_+|DUF4235-domain-containing-protein	gnl|CDD|379422	pfam14019, DUF4235, Protein of unknown function (DUF4235). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 88 and 119 amino acids in length.	3.00217e-11
NZ_CP021555.1|WP_003829607.1|2179162_2179864_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	6.59092e-99
NZ_CP021555.1|WP_052788286.1|2192601_2194941_+|YhgE/Pip-domain-containing-protein	gnl|CDD|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	6.56924e-89
NZ_CP021555.1|WP_106622492.1|2187666_2188365_-|histidine-phosphatase-family-protein	gnl|CDD|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.3181e-50

Protein sequences

>NZ_CP021555.1|WP_003829607.1|2179162_2179864_-|ABC-transporter-ATP-binding-protein
MAYIEFDKVVKEYPSGGTSIRALDEASFTADQGELTVILGQSGAGKTTALNILGGMDTATSGRVVVGERDITGLRKRDLITYRRNDVGFVFQFYNLVPNLTALENVELASQICPDHFDPAETLRKVGLGERMNNFPGQLSGGEQQRVSIARAIAKKPKLLLCDEPTGALDYETGKEVLQLLQDICRDEGMTVMIITHNSALAPMAHKVIHFRSGTVTSEEINTAPQPIADIEW
>NZ_CP021555.1|WP_103619685.1|2175394_2179153_-|FtsX-like-permease-family-protein
MATARHSHTGFPGGRPVKHLVKQRSQSVKRPVKQSESDDRGSSVSAVFVKDALRCWLRSWKRFVSIAVITLLGVAVLTGIYAGCRDAFLAASRFYDQQGLHDLQVLSTYGLTGDDVAALRRVEGVETVQPERSQTVTATVKGTKKTVTMQEIGTEGLDQPYLQQGDMPSKAGEVAVTQQFLNDSGLEIGDDLTVTPRSASSTVLVGAEDKSNSGSSKSSDGDTGTVGAAEDATTSNNEKEQSPQFPTELTITAVVLDPSDLNNPAGYSGMTAFRSTSSEDYVFFAPSDVVTGNVYTAISIAVAGASQYDTFSDDYDAAIKTVADRIESQIQTQRQKARRQQIVTSAQNTLDAAKADALKQLDEGQQQIDSNRAELEANETKLAESRTQLEQNKASITDGERQIAEGRAQIASARQQIAQGRQQIAGARAQLESGKTQLTSARQQLDAARAELTANRSKVEQGIAQIDQGVAQLDQMLQLIQQADDLLSQLDPNIDIDSSTWQTVKQLLTSLGITVPDVPSISSLRQQLDAKQNELQSQRSDAIKQKTELQQTLDGTIAPAQNALDQQNAQLTAKEQEAAAGEAELNAKLAELESNTAQLETQSAQLEAQAAQLASGKQQLEEGEKQLKDGEQQLEDGKQQLEDAQQELDEKRSEAESEFAKQQRRIDDVVNARWYMQTRSSIDGFSSLKSDVSSIESIGRAFPVVFLLVAVLMSLTTMTRMVEEDRGLIGTYLGLGYGGVVVSLRYLLFALLACLFGGGVGLLVGFLGIPAFLLIVIKGLYILPDVRLEYDWGYGTAGILLFVVGVGVATALACRSEIRHTPAALMRPKAPKAGARILLERIRPVWSRLSFLGKVTARNIFRFKSRLLMTVGGVAGCTALIICGFAINDTVDTIGVKQYGQIYQYDLMVVSNDDDAAAMRKQVKKDGRTTETLNLRVDSAEMSNAAQESETIQLMAVPNNSLNKLNDMVTLEEAGDEGWFGLSNFFGASGGGTVTLDDSGVIVAQSAANSLGVHAGDTVTVSNGGSSRAKIKVAAVVRNLIGSDVYISERLYDQKFAARGIDSSASDGESSTLTWNAMLAKLKGPDGEQAEYADRLGEESSVVKAVSCAHLEATFKFDLMAAVVALIVGLAGGLALVVLFTLANTNVSERVREMATLKVLGFYDREVHNYVNREMMILTGMGVVVGLPLGRWIGGLLTAALNMPSLYFEVEVHWYSYAIAVAVTLAFALLVQLFTNPVLDRIEPVSSLKSVE
>NZ_CP021555.1|WP_025341952.1|2173618_2175142_-|amino-acid-permease
MADTNANGNAQQSGSKLKSVESLDQTNAMERGLSNRHVQFIAIGGTIGTGLFLGSGKSISLTGPSIVFVYILVGVIMFFLMRAIGEMMYRDPSQHTFINFITRYLGNGWGHFAGWTYWAALVLLGMTEITAVSTYFITFFDTFGIDLTHWKWLIELCFLVSLVSVNLIAVKVFGEVEFWFSMIKITLIGAMIATAVVMIVIGYHYPAARIHGVDHVSPAGHAGLDNLFAGFSFAPNGWMAFLMSFQMVFFAYELLEFVGVTVSETKNPREVLPKAVNEIIVRVLIFYVGALVAIMCIVPWTSFKPNEDGSFASPFIMVFQYAGLNWASALVFFVVITAASSSLNSLLYSAGRHLYQLSEVSPSPMLNKIGQVSDRKVPARAILVSAVLILLSPIVNAIPGVSGAFVLFSSASSAVFLFIYILTLVAHRKYRRSDDFIPDGFVMPAWKVLNTVAIAFFVFIYLTLFLADDTRNSAIAGLVWLIGFGGFSLLRERYRSRDLKAALEHKE
>NZ_CP021555.1|WP_050825218.1|2172171_2172693_-|MarR-family-transcriptional-regulator
MGFEQEAVGELYASVWGNRSKMQREFTRGAHGEQFVLRELSLKGTQTPSQLATALQASSGRISTVLSSLEKKGWITRDIDSNDRRIIRVSLTDSGREESHRMIDEMRSAICWIFSQMGERRTREFVDLLSEFTTYMSICHPGQPRPTPEQVRGAFAERDKRVAEHMAAKHAEG
>NZ_CP021555.1|WP_052788289.1|2170119_2171988_-|ABC-transporter-ATP-binding-protein
MFRIMKYLSKAEIGQMLIALVSIVGQIWFDLELPDYMSDITTLVETPGSAMADIWTAGGKMLLISLGSVCCAIITGYIAARVASSFGQRLRSLEFRKVESFGPAEMSKFSTASLITRSTNDITQIQMFITMGLQLIVKSPIMAVWAVCKIAGEGFEWTVATAIAVVILLVAVVILMALVMPKFKAMQGLTDNINLVARENLTGLRVVRAYNAEDYQESKFTKANKDLTDTQLFTNRTMAIMMPLMNTVMNGLMLAVYWIGAYLIEAAELTDKLTVFSNMVVFSSYSVQVIMSFLLMSMVFVLWPRADVSAQRVMEVLNTEPIVKNGTKRVADIAKTGQTGTVEFKDVSFTYPDSREAMLQGINFKAEKGQTVAFIGSTGSGKSSLINLVPRFYDVSAGQVLVDGVDVRDYDMVALRDKIGYVPQRSVLFKGTVAGNISYGDKPGENDAVELADTSTPAGRKREALQLAADAANDGKLTDEQMSRVKAAADVAQASEFVNRMDGGFDSPIAQGGSNVSGGQKQRLSIARAVYRHPEILIFDDSFSALDFKTDRAVRDALAEEAKDSTKLIVAQRIGTIMNADRIVVLDEGKVVGQGTHKELLENCEVYRQIAESQLSESELTA
>NZ_CP021555.1|WP_042994364.1|2168158_2169988_-|ABC-transporter-ATP-binding-protein
MPRGPMGRGGAVEKPQDFGKVMGKLVRFCRKYVPAIIIALVLGAAGTICQIIGPDKLKDMTNEITKGLPAVVHGKPVLNSIDMGAVARIGWLLVVLYVGYALLSYIQSWMMATVTQRTAQELRESISKKINKLPLSYFDKVSYGDVLSRITNDVDAIGQTLGQSLGSLITSATLFVGALVMMFYDNWIMALCAIGSSIIGLIIMMVIMKASQKYFTRQQVALGDVNGHVEEMYAGHTIVKAYNGEADSIRRFERYNADLYDSGWKSQFLSGLMMPLMNFVGNFGYVVVCVVGAALAMDGQIEFGVIVAFMMYIRLFTQPLSQFAQAFQNLQRCAAASERVFGFLEESEMADESGKQALLGAQGHEVHGDVEFSHVRFEYEAGKPIINDFSASVSSGQKVAIVGPTGAGKTTMVNLLMRFYEIAGGSIAIDGVDTKSVPRWNVHDQFSMVLQDTWIFNGTVRENIAYSKPGVTDERIISACKAVGLHHYIMSLPNGYDTVLDENSSLSAGQKQLLTIARAMVQDAPILILDEATSSVDTRTEELIQKAMDALTVDRTSFVIAHRLSTIRDADMILVMNHGDVIERGTHEELLAAGGFYADLYNSQFALSD
>NZ_CP021555.1|WP_042994362.1|2167208_2168150_+|FAD:protein-FMN-transferase
MTGLTEQLPHTAAFPNALGTGLLLHTASALGGDLHQHIEDLISDYENVLSRFKGDSIVGQMRVATHGGTFDFPDWTLNLFDLYDHLFSATNGAIDPCVGEDLIRLGYDKSYSSVNEPNAAEHTGAIHGRATWDHAIEHHGTTLVTHGPVALDFGACGKGYLVDLIAERLGAAQSDLRYVIDAGGDLLVHTSEPITIALEDPSDPANAVGVAEISQGAFCASSPSRRHWTDAAGHQLHHLLNAIDGVPVNSVAATWVAATPPSLATAQADGLATALFTTPAAQLRAHFPFECAILTADRSAAQSPDFPGSFFMR
>NZ_CP021555.1|WP_015439311.1|2165685_2167104_-|hypothetical-protein
MDNATAVSATNVSGGSLQSTIKDLPIAKVWAFAVGQFGWALLSGIISNWLVYFYQPDQETISQGQTVFVPQGLVVLGLVTVVGGITAFARFFDAFVDPAVASLSDRCDSKAGRRMPFLKFAALPLAVVTVLVFWSPINGTSWVNAAFLFVTVIGYYIALTFYCTPYNALIAELGHDSKQQLTISTAISFTWVAGTAIAYVAPVIWGAFVPMMGRITAIRVTFTIMAAVAFACMLVPPLAIREKDYVNSQPTSESTIESLKQTFSDGEFRKFVCSDVVYWVAITTFQTGLPFFVTSLLKLPETTTTIYFVLMTGVSVLFYLPVNILANRVGKKRLLLIAFVIFTCAFAFAGALGSGVLALMPAMAQGLTLSVVGAIPMAAFGILPQAIVANIADASSKTTGQDRQGMFYAARTFAMKMGQSVAMLLFTGVSTIGMASGAGYRIAAVCAAVLCGLGGIVFAFYNEKKVLHVLGA
>NZ_CP021555.1|WP_103619680.1|2164006_2165056_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MLFGLGNTGSMTSADELNEQRDAEQSVAQVFERNDGNDGIDAGGPAASQTRESAVTIPAGTVVLAATPIGNVGDASARLVAFLERADIVAAEDTRRLFDLARRLGVYVNGRVVAYHDHNERDKADGLLDQVETGATVLVVSDAGMPTINDPGLAIVRRAIERGLPVTCAPGPSAVLDALALSGLPTDRFCYEGFLPRKHAERVQYLRTLLGERRTIVFYETPHRIADSMDDLLDAFGPNRPMALCRELTKDYEQIRRGPIGEIRQSVIDDPPRGEMVLVIGGASSEEAEAAAPSTLSVEDMAVLAIDRALEDGLRIKDAIAQVVQEHPLADGSLANRKQVYAAVLEIKG
>NZ_CP021555.1|WP_100218455.1|2163617_2163887_+|hypothetical-protein
MQSHSPHASAAVNHDAPPSPPIALTPSVACSPDTPIEVLWHIAQHAPELRRWLIANPRADAALLEFISQAGGPGVKRALAVLLESMEEE
>NZ_CP021555.1|WP_015439323.1|2180346_2181819_+|amino-acid-permease
MSTTDAPKKPRETDDVPVPATLRKSLKNRHIQLIALGGAIGTGLFYGSSESIALAGPSILLAYLIGGFAIFMIVRALSEMSVEDPKAGAFSYYATRYWSKRAGFISGWNYWFNYILVSMVELAVVGSFVNYWFPAIPTWVSAAVFLVLITAANLLGVSKFGEFEFWFAIIKIVAVIAMIIGGLAVIIFALPTASGIKASFANWFTVGGGFFPNGLMGHTDNGWTGLLMALVVVMFSFGGTELIGITAGETEDPKITIPRATNDIIWRILVFYIGALGVIMAVVPWNTIDGKSSPFVQIFDSVGIHAAAGILNFVCLTAVMSVYNSGLYANSRMLYSLAKQGNAPAYLGKLNSKGVPVAGVLTSAVITAIAVVVVFVWPEFAFNYLMSIATIAGIINWTMIMFTEMKFRKVVEAGGAPEDSDLAGKSGQEALDAIHFKLPFAKVTPWVVLVFLALVVVLMCFSASYRIAVIAGVIWLAILFVAYQITQAKK
>NZ_CP021555.1|WP_015439324.1|2181870_2182476_-|DUF624-domain-containing-protein
MNWLAPDSKFMRAWSNLIDGIWVNILMLVTSIPIITIGAALTAGHDACRRSIEGEGKGVTANYFRSFKANFVKATLLWLPFLVVLIALAWSWIVLQFTPLLIIKFALTIIWLIGFEWVFALQARFENTVAGTLKNAFIFGISHIAMTAALVVVDAVFVALLVGSWFYMPGGLFLLVILGYGTMLMLHIPVTERVFKPYLQQ
>NZ_CP021555.1|WP_003829602.1|2182626_2183469_-|carbohydrate-ABC-transporter-permease
MNENKPVKHGALWTVLFAVVSLFWIFPIVLVLINSFKQKAYISKNAFSLPAGKAFVGFENYVRGVETTQFFASFGWTLLITVGSVILILVCTSMCAWWIVRVNNWAAKLLYTLFLFNMIVPFQMVMFTLSKIADMLKLNTPWGLCIVYLGFGAGLAVFIFTGVIKGIPAELEESAMIDGASVPRIFFQIVVPIMKPSIVSVAILEAMWIWNDYLLPYLTLDLGKYKTISVAVQYLKGGYGSVDMGAMMACLVLAIIPIIVFYLVCQKYIVSGVMAGAVKG
>NZ_CP021555.1|WP_014484409.1|2183468_2184323_-|sugar-ABC-transporter-permease
MISMAGKAIRRWWALFALPTFAAFIIGFLVPFIMGVYLSFCEFTTVTDGEWIGLKNYTKALKDKEFLHALGFSTAFTIVTTIVINVIAFAIAYMLTKAIKGSTLFRSVFFMPNLIGGIILGYIWLLLLNGVLAHWGRALTYKASYGFWGLVILVCWQQIGYMMIIYIAGLQALPTDVLEAAAVDGANGRQTMFRIIIPLMMPSITVCSFLTVTNGFKLYDQNLALTNGAPSNMSEGLALNITRTFYGRMGWEGVGQAKAVLFFILVAVIALIQNKLTTSKEVAA
>NZ_CP021555.1|WP_106622446.1|2184693_2185710_+|LacI-family-transcriptional-regulator
MTTSIQDVAQKAGVSISTVSRSFTRPDLVSTKTRERVLAIADELNFSLSRSAAALKSGRSLRIAVLMSGHIRLWFTASVIEGLNEVLHAAGYDISVFQISSIEERREFFEMLPVRRNADAVIVVSFDIDNNEITQLASADVPIIGINSVDPEVRGFTAAVNINDVQGSTLAARHLINLGHRDIAYISTDRDVSLSFSVQNRFGAFTECCRNEGIEPQVIVCKVDDAGRYQISDVVTQLMSLPKLPTAIACQEDGIALPLMFQLERNGLSVPGDVSLIGWDDSFYTDDIGLTTIRQDPVDMARKAAHMTLDLIEEKPVDEPYIVAPAHLVVRSSTAKIR
>NZ_CP021555.1|WP_106622447.1|2185917_2187246_-|ABC-transporter-substrate-binding-protein
MMNRTVKSAVAVAAIAAMSLGTLAACGSSTSGDDSKGKVYYLNFKPEAADQWAALAKEYTKEKGVEVKVQTAASGTYEQTLKSEIAKTEAPTLFQVNGPVGYQNWKKYTADMSKTDVYKELTNQDVALKDGDKVVGVPYVMETYGLIYNKDILNKYFALDGAKATSMDEIDNFDTLKAVADDMQSRKDELGIKGAFTSAGFDSSSDWRFKTHLANLPLYYEFKDDNVTEQPAKIKGTYLPNYKKIFDLYITDSTTEPTQLSAKTGDDANSEFALGEAAFYQNGTWAWTDLQKAGMKAESVGMMPIYSGVKGEEKQGLATGSENYWCINDKASDADKKATEDFLSWVITSDTGKKAISQDMGFTTPFKTFDDVKFDNPLTEAAVEDQKSGKTQVSWNFTMMPSEEWKNKVGQALLEYAQGTGKWDAVKTAFVDGWASEYEASH
>NZ_CP021555.1|WP_106622492.1|2187666_2188365_-|histidine-phosphatase-family-protein
MDGTVAVDASCGKAGFLVLLRHGQTFWSESGQHTGRTNIPLTEVGRQQAMDAGARLREAFPEGFDPECVFSSPLKRACQTAELAGFAQHGILDGIAEWDYGRAEGRTRQQVSEASGFSWDVWRDGPRSLTPTLEGDWVDTLPDGEQVNVHSGAGETLDEVAARARAAIEEVTPLLQSGRNVLLVAHAHILRILTSQWLNVDPQFARLLRLDTAHYSVLSVYKGDNVIERWNA
>NZ_CP021555.1|WP_014484412.1|2188451_2188829_+|DUF4235-domain-containing-protein
MSDETNTGIASDADRVVEGLHRIDQKVDDLRNQRLNDPDSLGDKLVKSAVPALAGLVAGKLFQIAWDKGAARRNVIKGLAADAPQGLAMSLAFAAISAAFGAIVSQLSNQGSQAFVERRHRKASR
>NZ_CP021555.1|WP_021648767.1|2189857_2192605_+|YhgE/Pip-domain-containing-protein
MRTVWQVFLRDCKRILRNPVAAVVTLGVAVLPSLYAWFNILANWDPYSATGNLQVAVANEDRGTTNDLVGHLNAGKQVVIKLKHNDQLGWRFVSNEEQAVQGVQTGDYYAAIVLPKDFSASLVDSLTGTSKQPKIKYYVNEKKNAIAPKITDTGATTIDEQINSTFVTTVSNTVAAAISQAGDDLDQATNSTQNNVVADLGSVLSTIATVQDALTDLRTTLDQSDTALADARSTTASLQRSITAAQQASQQSGALLAETQDGSQVFAASLVSALDTSSAQLSGLTVNVNNAAGTINQSFNTAQNSVDTITNALNSPLDKTATSLDTLKDALNKAGISADTTDPTGKRIWDHINAVDDAISTQQAKINTFHEDTTRFIDSGKSATTNLSGAMSGTATGGIAALNTARSSLTGTVMPSLTSSLNSFAALNGTLGGTLTSLSGTLDQTNGLFDQLSSTIAQTRTTIGSAQDSLNQIIDDVSTVRTDVATLDSSAVYQKIRDTMHLDDKGFGEFMGSPVTLTTKVVYAIDNYGSAVTPFYTNLALWVGGFVLIAIYKLEVDRESIRRINAKQAYLGRWMLLVTIGFLQAIIATVGDLVLGIQCEHPLLFILAGIFCSFIYINIIYALAVAFRHIGKAIAVILVIVQIPGASGLYPIEMMPDFFRKLHPWLPFTYGINAMRGPIAGTYSNHYWLDMLHLFWYLPAALFVGLVVRRYAMNLNALFDRRLGDTDLMITEHNSMVNEQVSLASVFRTVSDSKELKAIITRRAHRFFARYPMMIVAGLALLTILPFVFLILLFVTQEKIAMLTSWILSIILIDAYLIVVEYTRESYAMQLGVSAMNADEFRDVMLNGYVWRRFRSHGRHEAASAESAVDTDPDIGEVTEQLTPFERTGSTDSSDSSKSSESTITDTNPAQGGAR
>NZ_CP021555.1|WP_052788286.1|2192601_2194941_+|YhgE/Pip-domain-containing-protein
MKLIWKIFARDVRQATRNVIAVIVAMGLVIVPALYAWYNIAASWDPYGNTKALKVAVANVDKGYKSDLMPITINVGETVTNTLRANHDLDWQFVDKDEAIDGVNSGAYYAALIIPKSFSADMMTVFSPTIKHAKIEYYLNEKINPIAPHITDQGASTVATTIDQTFVKTLASVALDLVSNVSNYAQSPQMAQYVNNATSHISTMSSRLTVAASQMDSYANLLGAANGIIDSTDKLLGSTGSAANTAKKALKQTRDGVNSLDSALSGAASGVETALQQAGASYDTVSKQLDTAFASIGSQSDQISGTLTDMQTKVNDQSASFGAYASALRELAGKSSSLPAGGDTIAKRLNAAADQATQTQQDLKNVADDLGRAAQSLVDGTADTDQTLKDIKAQIAAAKQSVTQAANDYQSTLKPQLNNLTASMGDVADQASSVIDGLSSTVNSVSNLSGGISASLRDIQTTLTDAAGNLNHSASKLDDLSAQLSGIASGSSTDLDSITTADPNAIASLLSAPVAVDRIPLYPVANYGSAMAPFYTILSIWVGAIILVAMMKVSVSDHEKAKILGFGNDLPLGSEVGLREAMIAGRVAGPAAALDVLTKPRADSPGNARQFGLHLYQEYFGRYMLFGFLALLQGTLVCLGDMFYLGVQCEHPVQFMMVGWLSALVFSNIVYTLTLSFGDIGKAIAVVLLVMQVAGSGGTFPIETLPSFFQAASKWLLFPYAVDAMHSAMAGSYGMEYWVSMGKLALFLVPSLLLGLLLRRPVIRFNDWIIRNLESTKVM

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP021555_2	2.2|451022|25|NZ_CP021555|CRISPRCasFinder	451022-451046	25	NZ_AP022849	Bosea sp. ANAM02 plasmid pANAM02, complete sequence	158326-158350	4	0.84
NZ_CP021555_2	2.4|451139|25|NZ_CP021555|CRISPRCasFinder	451139-451163	25	NZ_AP022849	Bosea sp. ANAM02 plasmid pANAM02, complete sequence	158326-158350	4	0.84
NZ_CP021555_2	2.1|450965|34|NZ_CP021555|CRISPRCasFinder	450965-450998	34	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	139667-139700	6	0.824
NZ_CP021555_2	2.1|450965|34|NZ_CP021555|CRISPRCasFinder	450965-450998	34	NC_016626	Burkholderia sp. YI23 plasmid byi_1p, complete sequence	1786163-1786196	7	0.794
NZ_CP021555_2	2.1|450965|34|NZ_CP021555|CRISPRCasFinder	450965-450998	34	NC_016654	Rhodococcus phage REQ3, complete genome	8845-8878	9	0.735
NZ_CP021555_2	2.1|450965|34|NZ_CP021555|CRISPRCasFinder	450965-450998	34	CP006880	Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence	671609-671642	10	0.706
NZ_CP021555_2	2.1|450965|34|NZ_CP021555|CRISPRCasFinder	450965-450998	34	NZ_CP017244	Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence	1652187-1652220	10	0.706
NZ_CP021555_2	2.1|450965|34|NZ_CP021555|CRISPRCasFinder	450965-450998	34	NZ_CP048421	Sphingomonas insulae strain KCTC 12872 plasmid unnamed3, complete sequence	166344-166377	11	0.676

1. spacer 2.2|451022|25|NZ_CP021555|CRISPRCasFinder matches to NZ_AP022849 (Bosea sp. ANAM02 plasmid pANAM02, complete sequence) position: , mismatch: 4, identity: 0.84

cgatttcgaggatgactacgaggat	CRISPR spacer
cgatttcgaggatgactgcgagcgc	Protospacer
*****************.**** ..

2. spacer 2.4|451139|25|NZ_CP021555|CRISPRCasFinder matches to NZ_AP022849 (Bosea sp. ANAM02 plasmid pANAM02, complete sequence) position: , mismatch: 4, identity: 0.84

cgatttcgaggatgactacgaggat	CRISPR spacer
cgatttcgaggatgactgcgagcgc	Protospacer
*****************.**** ..

3. spacer 2.1|450965|34|NZ_CP021555|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 6, identity: 0.824

ccgtg-acgatcgcgacttcgacgatcgcgacgac	CRISPR spacer
-cgtgcgcggacgcgacttcaccgatcgcgacgac	Protospacer
 **** .**. *********. *************

4. spacer 2.1|450965|34|NZ_CP021555|CRISPRCasFinder matches to NC_016626 (Burkholderia sp. YI23 plasmid byi_1p, complete sequence) position: , mismatch: 7, identity: 0.794

ccgtgacgatcgcgacttcgacgatcgcgacgac	CRISPR spacer
gcgtggccatcgcgacttcgacgatcgtgctgcc	Protospacer
 ****.* *******************.* .* *

5. spacer 2.1|450965|34|NZ_CP021555|CRISPRCasFinder matches to NC_016654 (Rhodococcus phage REQ3, complete genome) position: , mismatch: 9, identity: 0.735

ccgtgacgatcgcgacttcgacgatcgcgacgac	CRISPR spacer
ccgtgacgaccgcgacctcgacgacgacaccacc	Protospacer
*********.******.*******. .*. *. *

6. spacer 2.1|450965|34|NZ_CP021555|CRISPRCasFinder matches to CP006880 (Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence) position: , mismatch: 10, identity: 0.706

ccgtgacgatcgcgacttcgacgatcgcgacgac	CRISPR spacer
cttttgtccccgcgacttcgacgatggcgtcgac	Protospacer
*. * ..  .*************** *** ****

7. spacer 2.1|450965|34|NZ_CP021555|CRISPRCasFinder matches to NZ_CP017244 (Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence) position: , mismatch: 10, identity: 0.706

ccgtgacgatcgcgacttcgacgatcgcgacgac	CRISPR spacer
cttttgtccccgcgacttcgacgatggcgtcgac	Protospacer
*. * ..  .*************** *** ****

8. spacer 2.1|450965|34|NZ_CP021555|CRISPRCasFinder matches to NZ_CP048421 (Sphingomonas insulae strain KCTC 12872 plasmid unnamed3, complete sequence) position: , mismatch: 11, identity: 0.676

ccgtgacgatcgcgacttcgacgatcgcgacgac	CRISPR spacer
tcaaagcgatcgcgaccacgacgatcgcgatcgg	Protospacer
.*. ..**********. ************. . 

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	1200264 : 1214295	15	Bifidobacterium_phage(70.0%)	portal,tail	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP021555|1200264:1214295|DBSCAN-SWA
GTCATTTGACGTTCGGGTCGGCCGTCACATCGAACGTGAGGTCGACCCGGTCGGTTTCGTCGCCCGCCATGCGCATCAGACGCGAACGGTATACGCCGTCGGGCAGGCTGGGAAAGCCGTCGAGGGCGATCTCCACGGTCTCGCCCGGCCACATGCTTCCGAGCGGGTGCAGCGGCGTGCCGTCCTGGTTGGCGTCGTTCGCGTGGATGCTGCCCTTGATCTGCATCACCGGGCAGCGGTTCGCGGCCAGCATGCCGGCGGCGTGGGCGCGCAGCAGGTCAAGCTGGTCGGTGTCCGGATCCGACCACGCCGCCTCCCTCAAAGGCCACGGCTCGGTCTGCTCGCACAATGACATGTCCTCGCCCATGCAGGTCAGCTGCGCCTTGTCGGTGCCGGACCCGGAGGCGTAGACCCGCATCACCGGGCCGACGTGATCCACCGTGACGTCCTCCAAGTCGCCTCCGAAACGCCGGCAGGCCAAACGGTGCACGCGATCCTGGCCTATGTACACATCGGCGTCGGAACCCGCCTCGAAGCGCAGGCGCACGTGCTGCCCGTCGGCCAGATACGGGCGGAACCGCATATCCGGGCCGCCCTGCACGTCGGACAGTTTCGACAGGATCCCCGCGCAGGAGAGGTTCTGCACGTCGAACCCGTTGTACGTGCGCTCGTGGCCGCCCCCCTCGCCCCGGTACTGCCAGTCGATCGGGAGCATGCCGCCGGGCTTGCCCGTGGTGCACTGCCATCCGACCTCGCTGGCGATGCCGCGCAGGCTCATGCCCGACCAGCTGAACACGCTGGACGTGGTGCCGTTCTTGTCCGCGCCGTAGGTGCCCTCGCGCACCAGGTAGCGCGACGACAGGATCCCCATCGGCGAGTCGAGGCTGAAGCTCGTGTCCAGCCACGTGTCGGTGCGCGGCGTGATCGCCCCCATCATGACCGGCGTGCCGAGCTCGCCCTCCGGGGTCCACGAGCTCCGCCAGAACAACACGACCGAACGCCTGTCGGCGCACACCTCCCGGGCTCGCGCCGATGGCGTCGAACCGGGGATGGCGTTCCACGGCACCCGGATCCCCGAGGCCTCGCCCTCGCCCACATCCTTGCCCCTCGTGGTCGTCAGGGCGAAATCGCCGATGCTCATGGACCAGGAAAACGAAGGCAGATCCAACGGCGAGTCGATCAGGCCGGTCATCGTGTCGGCCAGGTACGCGCGCCACATCACGCGTCCAATCCGCGGTCGATCACCTCGAGCCGGCGACGGTACAGCGTCACCGGGTACGTCAGGGGCGATTTGTTGCCGTACGCCCAGACGCTGACCTGGTGCACGCCGGCGGGCACGTCAAGATCAAGCTCCACGATGCGGCTGCACATGTACCGGTTCACGTCTATCTCGTCGCACACCTCGTTGTTCAGGCCGCTGCCCGAATGTGCCATATCCCCTTTGATCTGCCCGTCAAGGCGGACCTGGATGTAATAGGATCCCATCCGGTCGTTCGCCGCCTGCCCGGGATCCTCCCCGACCGAGGCGAAGGCCTTCCATCTGAGGGATATGTGCCTGTTCGTGGCCAAGGCGAACGACACCCTGACCTGCTCGTGCCACGCCTGGTCCTCGTCTACCGTGTAGGCGGCGTCCACGACGCCGTACGCGATCAGGCCGTTCGCCGCGCCGCGTGGCTTCGCGTAATCCACGCGATCGCCCGTGGCCGGACGGCTCTCGGTCGCGGACGAGCCGGCGGGTGCCTGCCGGTAGGCGATCGGCACGCACCCGGCTGGAGCCGCGCCTCGCGAGCACCCCAGTTGCACCGAATTGTCGGAATCGCCCTGCGAGGCGTCGTTCGCCCTGATCCAAACCACGTCCACGCCGCCCGCGCCGCCCTCCGGCGCCGTGACCCGGCCTCCGTCGCTCCACGCGATCGAATACCCATCCTGCGCGTTGCGCTGGCAGACGGCGGCGCCCGCGCCGACGTTGTATTCCAATCCGCTGGTGCCGGTCACGTCCAGCCCGTAAAGGATGCCCGTGTTCTCGAACAAACCCTGTATGGCCCGCCGATGCTCGACCGGCGTGCAGCCGGCCCCCTTGGAATCAGGCGGCACTCCCAAAGCACCCATGTCAAAACCTCCGGAATCTACGAATATGAATCAAAATAAAAAACGGCGGGCTCACATCCACGTGTCATGCAGCTCCACGTCGCACCAGCCCGAACCCGAGCCGGTGAACACGCAACGCAACGCCCCGCCCGCCTCCACGTGCGGGAACGCGCGCTCGGACAGGCTCCGGCCAACCGACACGCCGCCCTGCACGGCCGTGCCCTCACGGCAATCCAGAACGACAGACCCGCTGACCGGAGCCTCATACCTGATGCGCCCGAAACCGGGGAACTGCAGCGTGCAGCCCGCGTCCAACGGCCCGTGCATGGTGAACACCGGATACGCGCGGGAGGAACCGTCATTGGCCAACGAGCACACGTTGCGCCCGTCGCTCATGACCACGCCATACGAAACCGGATAAGCCAAGCCCCCGCGACCATCGCCGTACCGGATCCCGCCTGACCAATTGCCCGCGAAGATCGGAAACAACTGGAACCGTTTCGCACGCCACGACAAACGCTCAGGACGAGGACACACGAAATGCAATGTCAGATTGTTCTCCAACAGTGGATTCCACTGCGAGTCGCGGCCCATCTGCGCCACGTAGCCCTCACAGTATGTGTCCTCGTCGCCGTCGACCATGCGCAGCCTGCAGGAGCGGTGCGCCGCGGTGTTGATGCGGCGCATCAGGGAGAGTAGATCCGCACGGCTGTAGCCGACCGCCTCGTAGTACACGGTCACGGTGCGGGCCGAATACAGGATATCCGTTTCGGGCACGTCATGCGCGCCGTCGCCCTGGCCGCGTTCGTGCAGCTCCACCTTCGCGTCCGGCAGCGTATCCCAGCCCTCCACGCCGTTGGCGGTGATGTACAGGCCCCGGTCGGACGAATCCGCGGGATTGAACCGGCAGACAAGCTCGTCACCGGCCCACAGCTCCCCGTAACGCGGGCTCAAAGTCCACAGGTCGTTCATCTTGAGAGCCTTCCCACGAGCTGAGCGGCGTTGCGGTACATGATCGACGCCGCCGTATACATGTCATCCGCCGGACGCACGATCTTCTGCTGGAACACGGGCGCTATCGTCTGGTTGACGGTCTGGTTGTTCGTCACCGGCTGGCTCAGCATCATCGGCGAGGGCTTGTAGAACCTCTCACGTGGAATCTGACGACGGTTCATGGCCGCGTACAAATCGGCACCGTAATAGCCGACCGATTTCACGTTGCTGACGAATTCGCCGCTTTTGACGCGCGCGTTCAACAGGGTGATATTGTCGTCCCCCGTGTAGGTGGCCTTGCCGGGCAGCAGCCCCTCGACGACACGGCCGCCACCGGCGTAGCCGCGCATCGAAACCCCGTAGCCGGCGAACAGGCCACCGGTCTTGCCGCCCGGGCGAACGCCAACGCTTGTATCCGGCACGTTCTTTGTCATGTGGGTCTCGATGAAGTTGCGGACGATGTTCGTGGTTATCGTGACCTCCCTCGGGGTTTCCAAGGGTTCGTTGTTAACATCGCGAATGGCCTGCAAAGCCTGATCGTTCTTGCCATAGATGTAACCGGTTTTGGGATCTATATGCCAGCCGTTCGCTTCGACCATTTTGTCGAACAGGGGAGTGTTGTTGCCCTTGAGGATGCCGGTCTTGTCATCGATCTTGGCTCCGCCGGCAATGGCCATCGCCACGTCGAACTGGCTCTTATCCAGATCAAGGTAGCCGGTTTTGGGGTCGATCTTCGCGTTGGTGGCGTCGGCGATCTTGTCCATGAGGTCTTTGTCGTCACCGGTCAAACGCACGGTCTTGTCATCGATTTTCTCGGCTTTCACCTTCACCTTGTCCAGCACGTCGCTGGCCTCGTCCGTAATCGTAATCTTTACGTCAACAGGGTTAGCGGCAGTGCTGTTCATATCCTCGATGCTCTGACGCAGGTTGTCGGCCTCACTGCGGGCCAACCCGTATCGGTCGGCCTGGGCAGCGGCCGCGTCGGCGCTCATGCCAGCTGCGGTCGCGTTGTCGATGTACGCCTGACGTGCCCGTTCGAGGATATCGCCCGCCTGCTGGGTAGCAGCAGCGGCATCGCCGTGGGCCTGACCCTCCTCGATGATCTTCTGCGCCGTGCTCTGCGCGGTGGACGCAAGGCCCTGCAGAGCGGACTGGCTGTCATACGCCTGAGACTCATAGCCCGCCAGAGCGTTGCCGTTGTCATCGAGCACTCGGCCGTTCTTCGCGATGCTCGTGTTAAGATCGAGTATGCCCTGATTGAATTGGGTGACGGCCTGATCCGCGGACAACTGCACTCCCGGCAGGCTGAGGAAGCCTTTCACCAGATCGTCAATGGCGTCGGAGAGGTCTTCGGCGCTTGTGGTGGCGTTGTCTGCGCTGTCGGCGTAGTTGTTGGTGCCTTCGGCGGCCGTGTCTCCGCTGTCCTTCGCTTTGGCTACTTCCGTGTTGGTTTTGCTGACCTGTTCCTTGGCTTTGCTGACCTGATCGGAGAGCTTATTGTAACTGTCTCGGATACTGTCTGTCTGCATGATGGACATGTTGTTTTCGGCGTTTTTCATCTGTTCGTTGAACAGTTTTTGCGCTTCCTTGGATCCGTTGACGGCCTTTGCGAACGTGCTGTATTCGATGCCGGCTTTGTCGAGTGCTTCTCCAAGAGAGCCTAAGCCGGTGGCGAACTTGTCTCCGAAGTCCCAGGTTTTGTCCTCGCCGCTGGCGATTTTCTTGATGAGTGTTTCGACAGCGTTCCCGGACTGGTTGATTGCGCTGGAGAATTCTTTGATGTTGGCTTTAGCGTCCTGTGCGGATTGGGCGAACCCCACAAGCAATGCCCCCGCGACCGTCAAGGCGATGCCCCATGGTCCGCCTAAGGCGGCGAACAGCCCGCTGCCGATGCTTTTCATGCCGTTCATCGCGGTCTGGCCTCGTGTCAGTCCGTTGGCAAGCGTGCCGGCGTTGGTTGATGTGCCAAGCATGGAGGTGCCAAGTTGGATGACGCCTTCCTTGAGCAGTGGTATGGCGGTGATGCCTCGCTGGAACGGGTCGAGCATCAGGCCGAAGTTCCGTGCCGTCTGCGAGCTGCTGGCGTTCAATGGCCCCATGGCGGAGTGCAGGGCGGTGAAGCCTCCTGCGAGCGCGGTCATCAGTACTATGCCCTGTTGTACTGGTGCGGGCAGTTGGCTGAACGCATCCACCAAGGTGTCGAGCGTTTGCACGAGGGAGCGCAATGGTCCCTGACCGCCCTCGCCCAAAGAGATCATGAGGGATTCGAAAGAGCCGCTCAGATTCTCCAGATCGCCTTTCAGGTTGTCGTTCTTCTTGGCGGCGAGGTCCGCGGCGTAGCCGGATTGGCTGACCTTCTTGGTCCATTCGTCGATGCCGCTCGCGCCCTCCGCGTAGAGCACGTTCGCTCCTTGGATGGCGTAACTGCCGAACATGGTCGCCATGGCGCTGTTGCGCTGTTCCTGGGTGAGTCCGCCGAGCTTCTCCTTGAGCTGTCCGGCGAGACTGCTCATGCCGACGAAGTTGCCTTGCGCGTCGTACAGGGTTATCCCGTATTCCTCGGTGGCCTTCCGCTGTTTTTCGGTCTGGTTGGTCAGGGCGAGCAGCACGGAGCGCAGTTGGGTGCCGGCTTCGGCTCCGATGATGCCTTGGTGCGCGAATGCGGCCAATGTGCCGACGGTGGTGTCGATGCTCAGGCCGAACTTGTTGGCGGTGGAGCCCACGTTGTTCAACGCCTCGCCGAAATCGCTTACGTTGCCGAGGGCTTCTCCGGCTCCTGCGGCGAGCAGGTCGGCGATATGCGTGGCGTCGGCGCCGGTCAAATTGAATTGCGCCATGGCCGAGCTCATGTATTCGGCGGCTTGGCCGACTTCCATGCCGTCGGACGCTGCGAGGTTCAATGCGCCGCTCAAACCGCCGGAGAGAATATCGGAGGTCGACAGGCCGGCTTTGCCGAGTTCGTTGATGGCGTCGGCGGATTCGGTGGCCGAGTATATGGTGTCGGCGCCGGCGTCGATGGCGGCCTGACGCAGTTGGGCCATCTCGTCGGCGGAGGCACCGGTGTTGGCCTGCACGGTGCTCATCGATGCGTCGAAGTCCGCCGCCATCTTGATTGCGGCCACGCCCAGCGCGGTGGCGGCCACACCGGCTGCGGCCACACCGGTGGTGATGAGCTTGGTCTTACCTCCGGCGGCTTCCATGGTGGTCGCAGCCTTCTGGCTTTCGCCGCTGACTTTGGCCATGCCGGCCGTGAAGTTCGAAGTGTCCGCGAGCAGGCGGACTGTGATGTTGCGGTTCAATCCGCCAGCCATAGCGGCCTCCTGAGATTTATCTTGGTTTGATTCCCACCGTCAATGCGGACTGCTTCAGCTCGTTCTCGTCCGCATGGTCTTTCTTCCACTCGTCGAGCTTGAGGGATTGCATGAGCGATATCTGGCATATGCCGACGTCGGCCGTGAAATGGAAGGGTGTCTGCTCGTCGTGGCAGACGCTTATGGGCATGCCGCATTGGGGGCATAATGAGTGTTCGTATTCGTCGAGCGCGAGCATCCATTCGCGTTCGGTCGCATCCCATTCGGTTTCCGGCGTGTAGCCGGTGATGCGCCGATGTTCGTCTCGTTCCACCCGATACGATGGTTCCCAGCCGAGCCAGCGTTTGTAGCTGATGCCGAGCTTCTGGCAGATTCGCAGTTCCCTTACTGTCTGCGGATTATCCGCGAGGCTGATTCGAGTGCGTCTTTTGGGTCGATGAGCTTCGCATTCAGGTCACGGATCGCATACCAGATGGGGCTGATCTGGCCGTCGGACAGTTCGGTCATGACGTTCGCCAGATCATCCACAGGGGTTTCCGGCACGGTCTTCCTGACCATGAGTCTGACGGCGTCGGCGCAGATGTCCTCGATGCGCTGCTTCGGTACGCCGTTCTCGGTGACGGTGTTCGCTTCGAGTACCTGACGCCACTGGGAGAGCGGCAGCGCCTCCAGGGTGATGCGGACGGTGTCGTCCTTCACCTCGCCTCGCAGCTTGTCGATTTGTTCGGCGATGCGTTTGGCGGCGGCGTTGCCGCCCTCGGTCACATGCTGCGCCATGGCGCGCTCCAGGTCGGCTCCCAATGCGGCGACCTTTTCGGCCTTCTCCTGATCCAATATGAGGTCGACGTCCACGCGCTTGCGCTTCACTTCCAAAGCCATGATTATCCCTTTCTGAAAGTCTGAAAACCTTTCTGAGAGAGAAGAGAGAATGCCCGTGCGGGGCCAGAAAGGTTTAGAATCCCCGCACGGAAGAATTGTCAGCCGCCGGCGATGGCCTCTTTCACCGTGACCGTCCGGCCTCCCTCACGGGCTGCGGCGGTCACGGTCGGAGGCGTCAGCCTTTTGGGCTCGAGATCTCTGCGGTCTCGGACTCCCAGCCGGGGGCCTTCGCGAACAGCGGAATCTTCGAGCGGATCATGGTGCTCGCGTCCGGGTTGATGACCTGCTTCTCACCGCAGATGACGCTCACGACGGTGAGCTTCTGCCCTACGGCGAGGGGTGTGTCGGTGGCTATGCCGCGACGGCGCACGATATAACCTGAGGCACCCTCGTGCATGAGGGTGACGGCCTCGTTCTGTTCCTGGTGCTCCGTGTTCGTGTTGTCGATGACCTCGATGCTGATGTCGCCGGCGCTCTTGCGGCCGGGGGCCCCGAAGTCCTGCACGGCGTTCTCGCGCTGGTCGGACACGGCGTCCTGCGACGGGTCGAAGCTCCATCCGCCGAGCATGACGTAGTTCGAGATGTCGGTGCCGGCTTCTAGCTCGGCCATGGTGGGGGCCTTGATGTCCTTGATCGTCGGCACCCATAGTGTGGTGATGTTGCCATCGGCGCTGGTGCCAGGAATCTCTGTACCCAGTTTCAGGGTCATAATGTGCTCCTTGAAGCAAAAGGCCACCCCGTGTGGGATGGCGTTGAAGACTTTTGGTAAATGATTGGTTGACTATGGTCGGCTCCACGTGAAGCGGAACCGGAGGACGCGCACCTGGTAGCGGCGCGCGGTGTCGTCGGCGGTCAGACCGGCCGCGTACGCGCCGGAATCCTCGTACAGGGTGAGCTGGCCGACCGTGTAGCCAGACGGCCGGGTGGGGGAGCGGTTCGCCAACGCGGGAATCAGCATGTCGTCACACCAGATGTTCACGCTGTCGACGGTGGTGCTGACGGCGCGAACCTCCAACAGGGCGGAGTGGGCGGTGAACCGCATCGTCTCCGCCGCCACATGACGGTCGGTGGAGACGCGCGCGATGATCCACGGCGGCATCTCCGACTCCAGCGGCTCCTCCTGCCGGTAGACCTTCACGCCGGACGGCATGGAGGGCAGCAGGTCGAGAACCGCATTGGTCAGGTCCATGACGCTCATAATCCGATGGCTCCTATCAGCATGTCGTCGGCGGCGTCGCCCACGTATTCGGCGAGCGTGGGCAGCTCCGTCTCCGCATGTTCGTAGAAGTCATGGGTTCCGCCGCCTTTCGCGGTGCCGAAGAACGCGATGTTGGCCAGATCGGAAGCTCCGCCGTCACGCGGGCTCACGTCCGCGTACACAGTGGTGCCGGTACTGCCCATCTCGTAGGCGACCTGCACCTTGCGGATGCCGGCGTTGCCGGAACCGGCAACGTCCTCCTGAATGGACTCCTTGACGTTCTGCGCGCCCTTCTTCACCGCCTTCGCGACGGCGATTGAGGCCTTGGCATGCGCGGCGGCGATCCGGCGGCCGAAAGAGGTCAGCTCCGAAGCGTCGATGGTCACGTCACTCATTGCTGTTGCCCACCTCCTTCACGTTCCACCGGCATGCGGTCGCATGCGACTTCTCGGACTGCATGTTCAACAACCTGAGCTTCCGCCCCTTGAGGTTCGGGTCGGCGGCTTCGGTCAGCTCACACACGTCACCCGGCAACAATCCCGTGGTGCCGTAGGGGAAGTGCACGTACATGCTCCACACGGGGGTGACGGCACCCAACGCTTCGACGATGCCGCCCTCCGTGTTCTCGGCGGCCAAGCCGCCGGAGGTCTGCACCTTGCACTTGCCCTCATACACGGTGTTCACGTCCGGTGCCACCAGTCCCGTTTCAGGGTCGGTGACCGGCTTGCCCATGTGAGTGACACGGCATTGGTCGGTCATCAACGATTCGGCGAGCTGTCGGCCTCGGTTGAGGATGTGCTGCACGTTCATCGGAACACCCCTATGGCGATGCCGCGCATGCCGAACCTGTTGCGGAGGGCTCGTTTCGTGCCCTCCGGCAGTTCGAGTGCGTCGATGATCTCGGAGTCGCCCTGACGGTAGCCGATCTGCACGTCGTCGATTCGCGCGTACGATTCGTCGCGGTGAGCGCCGGGGCCGCCGTTCGACTGCTGGACGAGTCCGGCTGCGACCATGCTGCACACGAGGCGCACGATGTCCGGGGGAACTGGGTCATAACCGGCGAGCATGGTGACGGTGACGGAACAGGGGACCATGTTCGGCAGGCTCCACAGGCTTTCCCTGTACAGGGCGTTGCCGAGCAGCTTCCAATCCCCGGTCTCCTCGCCGTCCACGAGCACGCGGCTCACGGAAATCACGGGGCGCATGGGCAAATCGAGCCTGCGTGAGGTCTCGCCGGGGATGGTCACCGTGTAGTCGCCACGTGTGATGGGGCAGCCTGCGGCGTCGCGTACCGCTGCGGAAACCGATTCGAGCAGCTTGTCCGCGAGCTTTTCGTCCGCGTATTCGATGCCGTATGAATCAAGGTCCTTGATCGTTGCCAGCGTGTCCATGAGGCACCCCTATGCGGTTATTCGACTTCGCCCACGTAGGGCATGGCCTCGTAGCTGCCGGCCATCACTTGCCCACCTTGAAGTGTACGGTGGCCAGCGCTTCGGGGCGCACGACCTTCGCGCCGTACAGGTGCAGGCCCTTGACGATGTCGTCGAAGCCCTTCTCCTTGCGGGTGGCCTCGACCTTGGCGATCTGCTCCGCGAACGTGGTGGCCGCGTTGGTGCCGGCGATGATGACGTTGCCCTCATCGGTCTGAGCCGAGGCAGAGCCGCCCTTGGCTGCGGGAGCGTTGTTGGACTTGAGGATGGTCATGCCCGCGGCCTCGCCGACCACGCCGTTGAGCAGCGTGGAATGAGCGGACTCGGCGCCAGCGACGAAACGGCTGTCCTTGCGCAGCAGGCCATAGAAGTCCGGGTTGACGATGACCCAACGGCCCGCGTCTGGCACGTTCTGCTTATCCAATGCGGTGGCCAGATCCACGATGGTGTCGTACGCCTTGGTGGCGGTGGCTCCGGAAATCGGGTCGAGCTTGCTCTTCGCGCCTGCTGCCATCAGGCCGGCCAGGTACTGGTCGGTCAGGTCGCGCAGCTTGTAGGCTGCGTCCCGGGAATATGCGGCGGTCAGGTTGTTCATGGCCTGGCGCTTCTCCACGTCGTCGATTTCGAACGCGAAGTACTTGCTCTGGTTGATGACGAGTTCGCCGGCGTCCTTGTCGGTGGCCGGTTCGATGGTGATGTCGGTGTGGGCCGTGTAGTCGCCGATGCTGATGTGCGCGATGCCGGTGATGTGCACGGTGTCGCCGTAGTTGGCGATGTCGCCCTCGTAGTCGCGGTTCACGGCGGAACCGTAGACGAGGTTCTTCTGGAGTTCCAGCAGGATGTTGGCGCTCCAGAGTTCGGGAATGAAATTGGTGATGGCCATTTAAGGCCTCCTTCCGTTAGTTGGCTCCGAGCAGGTCCTTCAGTCGCCCGTCCTGTTGGGCTTTGACGATTTCTGCGGGGCTCATGGTTTTCAGGTCGTCTCGGGTGAGCTGACCCTGATGGCGGTCGCCGTCCCGTGTTCCGCTGGGCGGCGTGATGTTCGCACCCGAGGGTGCTTGCTCGGCTTTCCCGAGATAAGGTTTCTGTTCCAGCAGTTCGCCGATGGAGTCGGCGATGGCCTGCGTGTCCACGCCGCCGTCATCCGTGACGGTGAATTTGGACAGGTCGAGGTAGCGCAGGGCGTCGGCCGGGTCGGTGAGCTTGCCGCTGGCTGCGGCGCGGACTTCGGCCTTGAGGATGCGCTGGTTGGCGGCGGCAAGGGCCTCGTCCTTGACGGCCTGTTCCTTCCGGGCGGCCTCGTATTCGGCTTCCTTGCCCTGCAGGGCGGCGATCTGTTTTTCGAGTTCGTCGACCTTGTCGGCCTTGGCGTAGGCTTCGTTCAGTTTCTTTTCGAGGTCGCGGTTGACTTTCCGCTGTCCTTCGAACTTCGACTGCCAATCCTCGCCGCCGGTGTTCTCCGGCTTCTTGGACTCGTTGTCGCCTGTCTGCTGGTTCTGGTTTGCGGGATCCATGTTCTTCCTTTCGATTCGCTGGATCATTGCTGGAAAATCTGGCCGCCGGAGGTGACCCATCGGCGGTATTCGCGTTCGCACTGGGCCGCGATCTCGGGGGTGAGGGGCATGCGGCCATCGTTGGGGTTGCGGCCCTCCAATACGGCCTCGTAGCGGAGCTTCGCGGTCTGCACGCGCTTCTCGGCGGCGGTCAACAGTTCGACGCGCCCCTGCCGGTACGTGTTGTCGTGCAGCCACATGCTTTTGCGGATCTCGGGCACCTTGCCGCGCCAGTCGTTGTCCACGTAGTAGCCGTTGGCCTTCAACGCGGCGATGGTCTTCTCCCGGTCGCCTCCGGTCAGCGAGTAGATGCCGTCGATGGACAGGCGGCGTTTCATTTTCCGGCCGGACTGCTGAGCGTATTGCATGTTGGCCCACCCGTATCGGGTGGTGCCCTCGCTGGTGGTCAGCGCCGTATAGCCTTTTCCCACCCTTTGCATGCCGCGTTTCGAGTTGACGACCTGGTAGATGTCGGCGCCGTCGCGGATGGCCTGCGCGTAGTTCGCGCCGAAACGCTTGTCCTGCTCCTCACGGGAGAGGCTTTTGAAACCCTCCATGGGGTCGCTGATCCACCCCTGTTGTTTGGCCATGCCATGGCTGCAGGGCACGTGGCGGCCGTGGCAGTGGGGGTGGCGCAGGAACCCCTCGTTGAAGCGGAACCATTTGCCGGCCAGCAGCATGCATCGGTCGCAGCAGGTGGCGGACTCGACGCGGATGTAGCCGACCTTGGGGCGGCTGGTGATGTCCAGTGATTCCGCCTGGCGGGCGGTGTCCATGACCGCCAGAGAGGTGAGCATGACCAGCAGGTTGCGCCCATATTCCAATGCCTCCAACGGCGAGCTGCCGGTGCGTATCGCGTGCAGGGCGGCGAACACGGGGGATTGGAAGTAGGATGCGATGTCGAGGCCGGACGGAGCCCAGCCCGCGAATGCGTTCGGGTTGGCCAAAGCATGGGGAGTGACGTACACGCCCTGTTCGGCGAGCATCATGCCGCTCGCGTCGATGGCCGTCTCCGCCGACTTGGTTTGGATGGTGGAGAACAGGGTGAGGAAGTCGCGGCTTATCGACTTCCACGACGCCTGGATGTTATTGGCGTCGACCCTGTTCCATGTTCTGCGCGCGGCCCTGTCCGCCGCCAGCTCCAACGTCGCCAGCCGTTTCTGACTGTAGGCCAGCACCTGCGATTCGACCGCCATCAGCGCCTCCGATCTGCAGGGCACGGTTCAACGATTCGAGTTCGGGGTCGGCCAGGGCGACGGCGCGCATGCGCATGATGCGCTGCACCTCGTCCGAGCTTTGCCCCATCTGCTCCGCGACCCATTGGATCGGGAAGCCGAGCTGCTTGTACTTGAGCATCGCGTCCGCCATCAGCGTCTCGCTGCGATACTGCGGGGTCGCGAACTGCACCTTTGAGTCGGCGATGATGTCCGCCTCATTCGCGTCGTTCTCGTAGCGCATGGCGATGCTGCAGATGTCGCGGATGGGGGATTTCAGGAAGCTGATGCGTTCGATGGTCTTGGATACGAGGCCGGCTTCGGCGACCTCGTATCCGGTGGCCGGAACCTCCGCGTTCGTCAGCAGGTAATGGCCGGGGGTGCGTGTTTCGGCGGCGATATGTTCCACGGCCTTCTCGATGACCGGGATGAACACGTTCAGGTTCGAGCTTGACCATTCGCCCAGGTTCACGTTGTCGCCGGTGAACTGGTAAATGCGCTCCAGCACCTGCTTGTCGAGTTCGATGGGCTTCTCGCCGACCTGCTGCCCCTCCTCGTTGTAGACGGGCTCGACGAGCGGGTCTCCGCCGAGGATGACTCGTGCCGGCAGTGAGGCGTAGTCCAATGCGTTCAGCAGGTAGGCCCATACGACGTTGACCGTGTCCTGCATCGATTCGACGTGCGCGATGTCGCTGATCGGCGCATTGTCCAATAGCATCTGGTTGCGGAACTCGCGCAATGGAATCGTGTCCAGACCGGTGGGCTGAGGGTCATTCATCTTCCAGCCATACACGTCGGGCGGCACGCGCTGGTCGGTCAGATCGAGCATCTTCTTACGTTCCATGCTGACCGTCCAGCCGGGCACCATGAGGGTGCCGTACTCCTTGTCGTCGCCCTGCTGGATGAGGAACCCGGCTGACGGCTGGCCGGTGCGCGCATCGTAGATGACTGCGGCGCTGTCCGGGTGCTCGAACGTGATGCGGGCCCTGCCGTCGACCTGCGTGACCAAGGCGAACGCGCGGCCCGTGGTGGTCATCATCAGCGCGGCTTCCTGCAGTCCGCGTTCGAAGTCGTTGCGGTCGAGGCATTTCATGATGCCGGTGCCGAGCTTCACGTCATCATATGGGACGAAGCCCTTGAACTTGATGCGTTCCACCGGGGCCTGCGCCACCGGGAGGCACCAGTTGTCCGAGAAATCGGAGAACCGGTCGCTCATGTAGCGCTTGAATTCCTTGGACGCGAACTTGAGCTTGCCGCGTTTGCCCAAGACGTAATCGGTGTGGGTGCCGATGCTGGGTCGACGGAACTGGATTTTGTCGGCCATACGGTTCGCCAATGAGGACAGTTCCTGCTGGCTGTATTCCAT

Protein sequences of DBSCAN-SWA_1

>NZ_CP021555|1200264:1214295|1211699_1212860_-|WP_016462994.1|DBSCAN-SWA
MELAADRAARRTWNRVDANNIQASWKSISRDFLTLFSTIQTKSAETAIDASGMMLAEQGVYVTPHALANPNAFAGWAPSGLDIASYFQSPVFAALHAIRTGSSPLEALEYGRNLLVMLTSLAVMDTARQAESLDITSRPKVGYIRVESATCCDRCMLLAGKWFRFNEGFLRHPHCHGRHVPCSHGMAKQQGWISDPMEGFKSLSREEQDKRFGANYAQAIRDGADIYQVVNSKRGMQRVGKGYTALTTSEGTTRYGWANMQYAQQSGRKMKRRLSIDGIYSLTGGDREKTIAALKANGYYVDNDWRGKVPEIRKSMWLHDNTYRQGRVELLTAAEKRVQTAKLRYEAVLEGRNPNDGRMPLTPEIAAQCEREYRRWVTSGGQIFQQ
>NZ_CP021555|1200264:1214295|1202423_1203323_-|WP_106622298.1|DBSCAN-SWA
MNDLWTLSPRYGELWAGDELVCRFNPADSSDRGLYITANGVEGWDTLPDAKVELHERGQGDGAHDVPETDILYSARTVTVYYEAVGYSRADLLSLMRRINTAAHRSCRLRMVDGDEDTYCEGYVAQMGRDSQWNPLLENNLTLHFVCPRPERLSWRAKRFQLFPIFAGNWSGGIRYGDGRGGLAYPVSYGVVMSDGRNVCSLANDGSSRAYPVFTMHGPLDAGCTLQFPGFGRIRYEAPVSGSVVLDCREGTAVQGGVSVGRSLSERAFPHVEAGGALRCVFTGSGSGWCDVELHDTWM
>NZ_CP021555|1200264:1214295|1212801_1214295_-|WP_106622301.1|portal|DBSCAN-SWA
MEYSQQELSSLANRMADKIQFRRPSIGTHTDYVLGKRGKLKFASKEFKRYMSDRFSDFSDNWCLPVAQAPVERIKFKGFVPYDDVKLGTGIMKCLDRNDFERGLQEAALMMTTTGRAFALVTQVDGRARITFEHPDSAAVIYDARTGQPSAGFLIQQGDDKEYGTLMVPGWTVSMERKKMLDLTDQRVPPDVYGWKMNDPQPTGLDTIPLREFRNQMLLDNAPISDIAHVESMQDTVNVVWAYLLNALDYASLPARVILGGDPLVEPVYNEEGQQVGEKPIELDKQVLERIYQFTGDNVNLGEWSSSNLNVFIPVIEKAVEHIAAETRTPGHYLLTNAEVPATGYEVAEAGLVSKTIERISFLKSPIRDICSIAMRYENDANEADIIADSKVQFATPQYRSETLMADAMLKYKQLGFPIQWVAEQMGQSSDEVQRIMRMRAVALADPELESLNRALQIGGADGGRIAGAGLQSETAGDVGAGGGQGRAQNMEQGRRQ
>NZ_CP021555|1200264:1214295|1203319_1206655_-|WP_106622299.1|tail|DBSCAN-SWA
MAGGLNRNITVRLLADTSNFTAGMAKVSGESQKAATTMEAAGGKTKLITTGVAAAGVAATALGVAAIKMAADFDASMSTVQANTGASADEMAQLRQAAIDAGADTIYSATESADAINELGKAGLSTSDILSGGLSGALNLAASDGMEVGQAAEYMSSAMAQFNLTGADATHIADLLAAGAGEALGNVSDFGEALNNVGSTANKFGLSIDTTVGTLAAFAHQGIIGAEAGTQLRSVLLALTNQTEKQRKATEEYGITLYDAQGNFVGMSSLAGQLKEKLGGLTQEQRNSAMATMFGSYAIQGANVLYAEGASGIDEWTKKVSQSGYAADLAAKKNDNLKGDLENLSGSFESLMISLGEGGQGPLRSLVQTLDTLVDAFSQLPAPVQQGIVLMTALAGGFTALHSAMGPLNASSSQTARNFGLMLDPFQRGITAIPLLKEGVIQLGTSMLGTSTNAGTLANGLTRGQTAMNGMKSIGSGLFAALGGPWGIALTVAGALLVGFAQSAQDAKANIKEFSSAINQSGNAVETLIKKIASGEDKTWDFGDKFATGLGSLGEALDKAGIEYSTFAKAVNGSKEAQKLFNEQMKNAENNMSIMQTDSIRDSYNKLSDQVSKAKEQVSKTNTEVAKAKDSGDTAAEGTNNYADSADNATTSAEDLSDAIDDLVKGFLSLPGVQLSADQAVTQFNQGILDLNTSIAKNGRVLDDNGNALAGYESQAYDSQSALQGLASTAQSTAQKIIEEGQAHGDAAAATQQAGDILERARQAYIDNATAAGMSADAAAAQADRYGLARSEADNLRQSIEDMNSTAANPVDVKITITDEASDVLDKVKVKAEKIDDKTVRLTGDDKDLMDKIADATNAKIDPKTGYLDLDKSQFDVAMAIAGGAKIDDKTGILKGNNTPLFDKMVEANGWHIDPKTGYIYGKNDQALQAIRDVNNEPLETPREVTITTNIVRNFIETHMTKNVPDTSVGVRPGGKTGGLFAGYGVSMRGYAGGGRVVEGLLPGKATYTGDDNITLLNARVKSGEFVSNVKSVGYYGADLYAAMNRRQIPRERFYKPSPMMLSQPVTNNQTVNQTIAPVFQQKIVRPADDMYTAASIMYRNAAQLVGRLSR
>NZ_CP021555|1200264:1214295|1208315_1208732_-|WP_016463000.1|DBSCAN-SWA
MSVMDLTNAVLDLLPSMPSGVKVYRQEEPLESEMPPWIIARVSTDRHVAAETMRFTAHSALLEVRAVSTTVDSVNIWCDDMLIPALANRSPTRPSGYTVGQLTLYEDSGAYAAGLTADDTARRYQVRVLRFRFTWSRP
>NZ_CP021555|1200264:1214295|1200264_1201485_-|WP_106622296.1|DBSCAN-SWA
MMWRAYLADTMTGLIDSPLDLPSFSWSMSIGDFALTTTRGKDVGEGEASGIRVPWNAIPGSTPSARAREVCADRRSVVLFWRSSWTPEGELGTPVMMGAITPRTDTWLDTSFSLDSPMGILSSRYLVREGTYGADKNGTTSSVFSWSGMSLRGIASEVGWQCTTGKPGGMLPIDWQYRGEGGGHERTYNGFDVQNLSCAGILSKLSDVQGGPDMRFRPYLADGQHVRLRFEAGSDADVYIGQDRVHRLACRRFGGDLEDVTVDHVGPVMRVYASGSGTDKAQLTCMGEDMSLCEQTEPWPLREAAWSDPDTDQLDLLRAHAAGMLAANRCPVMQIKGSIHANDANQDGTPLHPLGSMWPGETVEIALDGFPSLPDGVYRSRLMRMAGDETDRVDLTFDVTADPNVK
>NZ_CP021555|1200264:1214295|1207709_1208243_-|WP_106622300.1|DBSCAN-SWA
MTLKLGTEIPGTSADGNITTLWVPTIKDIKAPTMAELEAGTDISNYVMLGGWSFDPSQDAVSDQRENAVQDFGAPGRKSAGDISIEVIDNTNTEHQEQNEAVTLMHEGASGYIVRRRGIATDTPLAVGQKLTVVSVICGEKQVINPDASTMIRSKIPLFAKAPGWESETAEISSPKG
>NZ_CP021555|1200264:1214295|1208728_1209118_-|WP_106622479.1|DBSCAN-SWA
MTIDASELTSFGRRIAAAHAKASIAVAKAVKKGAQNVKESIQEDVAGSGNAGIRKVQVAYEMGSTGTTVYADVSPRDGGASDLANIAFFGTAKGGGTHDFYEHAETELPTLAEYVGDAADDMLIGAIGL
>NZ_CP021555|1200264:1214295|1210187_1211045_-|WP_016462996.1|DBSCAN-SWA
MAITNFIPELWSANILLELQKNLVYGSAVNRDYEGDIANYGDTVHITGIAHISIGDYTAHTDITIEPATDKDAGELVINQSKYFAFEIDDVEKRQAMNNLTAAYSRDAAYKLRDLTDQYLAGLMAAGAKSKLDPISGATATKAYDTIVDLATALDKQNVPDAGRWVIVNPDFYGLLRKDSRFVAGAESAHSTLLNGVVGEAAGMTILKSNNAPAAKGGSASAQTDEGNVIIAGTNAATTFAEQIAKVEATRKEKGFDDIVKGLHLYGAKVVRPEALATVHFKVGK
>NZ_CP021555|1200264:1214295|1209119_1209542_-|WP_016462998.1|DBSCAN-SWA
MNVQHILNRGRQLAESLMTDQCRVTHMGKPVTDPETGLVAPDVNTVYEGKCKVQTSGGLAAENTEGGIVEALGAVTPVWSMYVHFPYGTTGLLPGDVCELTEAADPNLKGRKLRLLNMQSEKSHATACRWNVKEVGNSNE
>NZ_CP021555|1200264:1214295|1206671_1206968_-|WP_016463003.1|DBSCAN-SWA
MERDEHRRITGYTPETEWDATEREWMLALDEYEHSLCPQCGMPISVCHDEQTPFHFTADVGICQISLMQSLKLDEWKKDHADENELKQSALTVGIKPR
>NZ_CP021555|1200264:1214295|1207039_1207534_-|WP_016463002.1|DBSCAN-SWA
MALEVKRKRVDVDLILDQEKAEKVAALGADLERAMAQHVTEGGNAAAKRIAEQIDKLRGEVKDDTVRITLEALPLSQWRQVLEANTVTENGVPKQRIEDICADAVRLMVRKTVPETPVDDLANVMTELSDGQISPIWYAIRDLNAKLIDPKDALESASRIIRRQ
>NZ_CP021555|1200264:1214295|1201481_1202372_-|WP_106622297.1|DBSCAN-SWA
MGALGVPPDSKGAGCTPVEHRRAIQGLFENTGILYGLDVTGTSGLEYNVGAGAAVCQRNAQDGYSIAWSDGGRVTAPEGGAGGVDVVWIRANDASQGDSDNSVQLGCSRGAAPAGCVPIAYRQAPAGSSATESRPATGDRVDYAKPRGAANGLIAYGVVDAAYTVDEDQAWHEQVRVSFALATNRHISLRWKAFASVGEDPGQAANDRMGSYYIQVRLDGQIKGDMAHSGSGLNNEVCDEIDVNRYMCSRIVELDLDVPAGVHQVSVWAYGNKSPLTYPVTLYRRRLEVIDRGLDA
>NZ_CP021555|1200264:1214295|1211061_1211676_-|WP_016462995.1|DBSCAN-SWA
MDPANQNQQTGDNESKKPENTGGEDWQSKFEGQRKVNRDLEKKLNEAYAKADKVDELEKQIAALQGKEAEYEAARKEQAVKDEALAAANQRILKAEVRAAASGKLTDPADALRYLDLSKFTVTDDGGVDTQAIADSIGELLEQKPYLGKAEQAPSGANITPPSGTRDGDRHQGQLTRDDLKTMSPAEIVKAQQDGRLKDLLGAN
>NZ_CP021555|1200264:1214295|1209538_1210123_-|WP_016462997.1|DBSCAN-SWA
MDTLATIKDLDSYGIEYADEKLADKLLESVSAAVRDAAGCPITRGDYTVTIPGETSRRLDLPMRPVISVSRVLVDGEETGDWKLLGNALYRESLWSLPNMVPCSVTVTMLAGYDPVPPDIVRLVCSMVAAGLVQQSNGGPGAHRDESYARIDDVQIGYRQGDSEIIDALELPEGTKRALRNRFGMRGIAIGVFR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_106622296.1|1200264_1201485_-	hypothetical protein	A0A2H4P925	Arthrobacter_phage	1.4e-09	27.0
WP_106622297.1|1201481_1202372_-	hypothetical protein	NA	NA	NA	NA
WP_106622298.1|1202423_1203323_-	hypothetical protein	NA	NA	NA	NA
WP_106622299.1|1203319_1206655_-|tail	phage tail tape measure protein	I3NL90	Bifidobacterium_phage	1.0e-192	48.6
WP_016463003.1|1206671_1206968_-	hypothetical protein	I3NL91	Bifidobacterium_phage	2.3e-35	65.3
WP_016463002.1|1207039_1207534_-	hypothetical protein	I3NL92	Bifidobacterium_phage	4.6e-57	71.2
WP_106622300.1|1207709_1208243_-	hypothetical protein	I3NL93	Bifidobacterium_phage	1.3e-81	87.2
WP_016463000.1|1208315_1208732_-	hypothetical protein	I3NL94	Bifidobacterium_phage	1.0e-41	61.6
WP_106622479.1|1208728_1209118_-	hypothetical protein	I3NL95	Bifidobacterium_phage	3.2e-37	62.3
WP_016462998.1|1209119_1209542_-	hypothetical protein	I3NL96	Bifidobacterium_phage	6.3e-39	86.4
WP_016462997.1|1209538_1210123_-	hypothetical protein	NA	NA	NA	NA
WP_016462996.1|1210187_1211045_-	hypothetical protein	E5DV53	Deep-sea_thermophilic_phage	6.4e-62	49.0
WP_016462995.1|1211061_1211676_-	hypothetical protein	NA	NA	NA	NA
WP_016462994.1|1211699_1212860_-	hypothetical protein	NA	NA	NA	NA
WP_106622301.1|1212801_1214295_-|portal	phage portal protein	D7NW49	Streptomyces_phage	5.1e-59	32.0