CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP022318	Brachybacterium avium strain VR2415 plasmid unnamed2, complete sequence	0 crisprs	NA	0	0
NZ_CP022317	Brachybacterium avium strain VR2415 plasmid unnamed1	0 crisprs	DEDDh	0	1
NZ_CP022316	Brachybacterium avium strain VR2415 chromosome, complete genome	4 crisprs	Cas9_archaeal,DEDDh,cas3,csa3,WYL,DinG	2	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

50162 : 57226

Mycobacterium_phage(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_089066527.1\|50162_50765_+	hypothetical protein	A0A1B3B013	Gordonia_phage	1.0e-21	38.2
WP_089066528.1\|50761_51478_+	HNH endonuclease	A0A1S6L216	Vibrio_phage	4.4e-16	32.9
WP_089066529.1\|51477_51747_+	hypothetical protein	NA	NA	NA	NA
WP_089066530.1\|51737_52547_-	hypothetical protein	NA	NA	NA	NA
WP_089066531.1\|52654_52903_-	glutaredoxin family protein	C3U2K9	Lactococcus_phage	1.2e-08	33.8
WP_089066532.1\|53057_53303_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_089066533.1\|53384_54191_-	hypothetical protein	A0A2P1CEV6	Mycobacterium_phage	5.1e-05	40.0
WP_157697282.1\|54263_54467_-	hypothetical protein	NA	NA	NA	NA
WP_157697283.1\|55211_55559_-	hypothetical protein	NA	NA	NA	NA
WP_089066536.1\|55611_56007_-	DUF3846 domain-containing protein	NA	NA	NA	NA
WP_089066537.1\|56105_56468_-	hypothetical protein	NA	NA	NA	NA
WP_089066551.1\|56606_56801_-	hypothetical protein	A0A0Y0C4W7	Mycobacterium_phage	7.0e-09	50.8
WP_089066538.1\|56845_57226_-	hypothetical protein	A0A2D1GQ59	Mycobacterium_phage	3.1e-13	40.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP022316

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022316_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022316_1

39540-39692

Orphan

Consensus_repeat	Method
TCGGCCTCGGATCCCTACGGCCAG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP022316_1

>merge|NZ_CP022316|1|39540-39692|CRISPRCasFinder
TCGGCCTCGGATCCCTACGGCCAGCAGATGGGCGGGCAGGATCCCTTCGCGCAGCCGTCCGCCGGTTCGGCCTCGGATCCCTACGGCCAGGGCCAGCAGGCCTGGTCGGCCGCCCCGGGCTCCGGACCGTCGGCCTCGGAGCCCTTCGCGCAG

>NZ_CP022316|1|1|39540-39692|CRISPRCasFinder
TCGGCCTCGGATCCCTACGGCCAG	CAGATGGGCGGGCAGGATCCCTTCGCGCAGCCGTCCGCCGGT
TCGGCCTCGGATCCCTACGGCCAG	GGCCAGCAGGCCTGGTCGGCCGCCCCGGGCTCCGGACCG
TCGGCCTCGGAGCCCTTCGCGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022316.1\|WP_089066216.1\|45526_46786_+\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|236437
NZ_CP022316.1\|WP_089063772.1\|42399_44604_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP022316.1\|WP_089066214.1\|37051_39313_+\|bifunctional-cytidylate-kinase/GTPase-Der	unknown	unknown	gnl\|CDD\|236546
NZ_CP022316.1\|WP_089063773.1\|44718_45324_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP022316.1\|WP_089063766.1\|34132_35005_+\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293
NZ_CP022316.1\|WP_089063776.1\|49480_50866_+\|MmgE/PrpD-family-protein	unknown	unknown	gnl\|CDD\|377179
NZ_CP022316.1\|WP_089063768.1\|35921_37031_+\|prephenate-dehydrogenase	unknown	unknown	gnl\|CDD\|235824
NZ_CP022316.1\|WP_157697193.1\|40302_40779_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240032
NZ_CP022316.1\|WP_089063769.1\|39985_40276_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022316.1\|WP_089063775.1\|48019_49396_+\|NAD-dependent-succinate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143418
NZ_CP022316.1\|WP_157697011.1\|41424_42357_-\|formyltetrahydrofolate-deformylase	unknown	unknown	gnl\|CDD\|235676
NZ_CP022316.1\|WP_089063761.1\|26660_28214_-\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|235579
NZ_CP022316.1\|WP_089063767.1\|35004_35925_+\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NZ_CP022316.1\|WP_089063765.1\|32957_33956_+\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
NZ_CP022316.1\|WP_089063764.1\|32010_32961_+\|protoheme-IX-farnesyltransferase	unknown	unknown	gnl\|CDD\|235293
NZ_CP022316.1\|WP_089063774.1\|46785_47994_+\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NZ_CP022316.1\|WP_089063762.1\|28285_29401_-\|transaldolase	unknown	unknown	gnl\|CDD\|235117
NZ_CP022316.1\|WP_089063771.1\|40775_41393_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022316.1\|WP_089063760.1\|24948_26664_-\|6-phosphogluconolactonase	unknown	unknown	gnl\|CDD\|378404
NZ_CP022316.1\|WP_089063763.1\|29570_31676_-\|transketolase	unknown	unknown	gnl\|CDD\|223100

Protein	Function_ID	Function_description	E-value
NZ_CP022316.1\|WP_089063772.1\|42399_44604_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.72649e-85
NZ_CP022316.1\|WP_089066214.1\|37051_39313_+\|bifunctional-cytidylate-kinase/GTPase-Der	gnl\|CDD\|236546	PRK09518, PRK09518, bifunctional cytidylate kinase/GTPase Der; Reviewed.	0
NZ_CP022316.1\|WP_089066216.1\|45526_46786_+\|aspartate-aminotransferase-family-protein	gnl\|CDD\|236437	PRK09264, PRK09264, diaminobutyrate--2-oxoglutarate transaminase.	0
NZ_CP022316.1\|WP_089063766.1\|34132_35005_+\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	9.05543e-85
NZ_CP022316.1\|WP_089063776.1\|49480_50866_+\|MmgE/PrpD-family-protein	gnl\|CDD\|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	1.57363e-124
NZ_CP022316.1\|WP_089063768.1\|35921_37031_+\|prephenate-dehydrogenase	gnl\|CDD\|235824	PRK06545, PRK06545, prephenate dehydrogenase; Validated.	1.06207e-116
NZ_CP022316.1\|WP_089063773.1\|44718_45324_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.56427e-12
NZ_CP022316.1\|WP_157697193.1\|40302_40779_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240032	cd04676, Nudix_Hydrolase_17, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.73775e-37
NZ_CP022316.1\|WP_089063775.1\|48019_49396_+\|NAD-dependent-succinate-semialdehyde-dehydrogenase	gnl\|CDD\|143418	cd07100, ALDH_SSADH1_GabD1, Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like. Succinate-semialdehyde dehydrogenase 1 (SSADH1, GabD1, EC=1.2.1.16) catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde (SSA) to succinate. SSADH activity in Mycobacterium tuberculosis (Mtb) is encoded by both gabD1 (Rv0234c) and gabD2 (Rv1731). The Mtb GabD1 SSADH1 reportedly is an enzyme of the gamma-aminobutyrate shunt, which forms a functional link between two TCA half-cycles by converting alpha-ketoglutarate to succinate.	0
NZ_CP022316.1\|WP_157697011.1\|41424_42357_-\|formyltetrahydrofolate-deformylase	gnl\|CDD\|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	9.05806e-129
NZ_CP022316.1\|WP_089063761.1\|26660_28214_-\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0
NZ_CP022316.1\|WP_089063767.1\|35004_35925_+\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	5.95972e-90
NZ_CP022316.1\|WP_089063765.1\|32957_33956_+\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	2.69409e-124
NZ_CP022316.1\|WP_089063764.1\|32010_32961_+\|protoheme-IX-farnesyltransferase	gnl\|CDD\|235293	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional.	1.16936e-130
NZ_CP022316.1\|WP_089063774.1\|46785_47994_+\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	1.66398e-81
NZ_CP022316.1\|WP_089063762.1\|28285_29401_-\|transaldolase	gnl\|CDD\|235117	PRK03343, PRK03343, transaldolase; Validated.	0
NZ_CP022316.1\|WP_089063760.1\|24948_26664_-\|6-phosphogluconolactonase	gnl\|CDD\|378404	pfam10128, OpcA_G6PD_assem, Glucose-6-phosphate dehydrogenase subunit. Members of this family are found in various prokaryotic OpcA and glucose-6-phosphate dehydrogenase proteins. The exact function of the domain is, as yet, unknown.	2.88203e-72
NZ_CP022316.1\|WP_089063763.1\|29570_31676_-\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0

>NZ_CP022316.1|WP_089066214.1|37051_39313_+|bifunctional-cytidylate-kinase/GTPase-Der
MHTSAPHGPSDPASPRPAEGITIAIDGPAGSGKSTVSRLVADALDGGILDTGAMYRSVTWWCLDQGIDLADREGVARAAEEIDLVQGTDPSGATVVVAGTDITAEIRTERISQQVSTVATNTLVRAILQRRQRELFFAAAAERGFCVAEGRDITTVVAPDAHVRVLLTASDEERMRRRAVELELDDTEDTRERMADQVLRRDRDDATVSEFRTAAEGVETVDTTGLGIEDVVEQVLMLVAAAESAQEEALHGRPEPAARESVLVSGGEPRADGATGPTDEDVEAALRAGLSDYSLDDEDLALLTGHEDEAPYSAAPRNLPVVAVVGRPNVGKSTLVNRILGRREAVVEDRPGVTRDRVFYEAEWTGKDFWLVDTGGWEDRVQGMAYRVAEQAEVAVSLADVVMFIVDANVGITTTDEQLLKVLRKAKVPLVLVANKVDDQRGELEAAALWNLGLGEPHAVSALHGRGSGDLLDAVVAAMPEEGRGAAADHGPRRVALLGRPNVGKSSLLNRLAKEQRVVVDDIAGTTRDPVDEKITLGGKEWTFVDTAGIRRRILQAQGADYYASLRTRAALDRAEVAVVLLEASEPISTQDLKIIDMVLESGRALVLAFNKWDLLDEERHKALEHEIERDLAHVAWAPRVNISAQTGRHAEKLVPAIETSLESWDRRIATGRLNAFLGQLVAAHPHPLRGGKQSRILFATQARTRPPRFVIFASGFLEHGYRRFIERRLREDFAFTGSPIVIGVRIREKRRR
>NZ_CP022316.1|WP_089063768.1|35921_37031_+|prephenate-dehydrogenase
MTALVPSPVRIIGTGLIGGSLGLALRRAGVEVQVEDASPGTAALAVELGVGALPGAEAPDPSLVLVAAPPDVAAALVDRALRSWPDALVADVASVKATVLDGVRQRARPGDLPRYIGAHPMAGREVSGVIAARADLFLGRPFVVVPHQGTAPRAVSILRGLATEIGSVPTTMDAAAHDIAVAQVSHVPQVMSSLMAATLLQPSEPALGLAGQGLRDTTRIADSDTRLWVEILGANAGAVGHVLAEVRDRLEGVLTALGTLEGDPDPGTGSRRALADLISAGNRGVRRIPGKHGGATDAFATVVVLVPDRPGELARLLTEIGQIGVNLEDLRLEHELERAVGLAHIAIDASREDLLTRELAERGWRVADA
>NZ_CP022316.1|WP_089063767.1|35004_35925_+|rRNA-pseudouridine-synthase
MAADRSGRGGSGGRGAGAGRTGGRPPRRRSAFTPPRQVRLRDGEGKPVVPDAEPNGEPTEAHRTDGERLQKVLAGAGFGSRRACEALISGGRVRVDGEIVQEQGVRVDPAAQVIHVDGRRLQLDESKLTLVLNKPRAVVSAMSDPEGRRDLSEFTAAHSQRLYHVGRLDYETEGLLLLTNDGELAHRLTHPSFEVDKTYVCRFDAPGGPPRGLVKVLREGVELDDGPARADRARVLAQDGREAVVEVTLHEGRNRIVRRMFASQGFELTALMRTRIGPVVLGDLPTGTTRELTGRELGTLMAEVGL
>NZ_CP022316.1|WP_089063766.1|34132_35005_+|ParA-family-protein
MSPTSSQQLDIDLGPTGRPMPELPEPAPLDGHGPARIISMVNQKGGVGKTTSVINLGAALAELGRKVLLVDLDPQGALSAGTGVNPYELDVTVYNLLMERGHDVREVIQETHTENLDVLPANIDLSAAEVTLVNEVAREMALARVLRPVADDYDVIIIDCQPSLGLLTVNALAASHGVIIPLEAEYFALRGVALLVETIEKVQDRINPRLELDGILITMFDPRTLHAREVCQRVVEAFPDQVLHTTINRTVKFPDASVAAEPIISFATSNKGAAAYRQLARELISRGAAA
>NZ_CP022316.1|WP_089063765.1|32957_33956_+|site-specific-tyrosine-recombinase-XerD
MTPGGASRPAQEQALRPGDRRILEQYLSHLRIERGLSTNTLAAYERDLRRYLCDLARQEIDPATVQSQQLGTWLQALRTGADGGSVLSPASAARSLAAVRGLHAFLDSERVSTTGDPSRLVPTPALPQRLPHPLSIEQVEALIEAAGRPGTGRDSAARALRDRALLEVLYGLGARISEATGLDIDDVEVQERAAVLRGKGDKHRIVPVGRYALEALEAYLTRGRPALAARGRGTPAVFLGSRGTRLTRQAAWQLIQRAAEAAELTDLPEPISPHTLRHSYATHLLHGGADVRSVQELLGHASVTTTQLYTQVTVDSLRETHAGAHPRARRGA
>NZ_CP022316.1|WP_089063764.1|32010_32961_+|protoheme-IX-farnesyltransferase
MTATQGASVRNSGRDGDRTPRTPLSVLRGYVALTKPRIIELLLITTIPTMFLAAGGFPSLWLILTTMIGGYLAAGGANALNMYLDRDIDAKMKRTKNRPLVTGEISPRAGLIFGIVLSIVSTLWLGLLVNWMSAALGAGAILLYVVFYTILLKRRTSQNIVWGGVAGCMPVLIGWSAVTGTVSWTAVLLFLVIFFWTPPHYWPLAEKFSRDYADAGVPMLPVVASRGKVAGQMIMHTALMVFASLAIIPLGATGWVYGVGAVAAGAWFGFLVVRYALRVRRGLSGKALGPMVVFHGSITYLTVLFVALAIDPFVTL
>NZ_CP022316.1|WP_089063763.1|29570_31676_-|transketolase
MTETFKAPEGWTALDKRAVDTARVLAADAVEKVGSGHPGTAVSLAPAAYLLYQDLMRHDPADPTWLGRDRFILSAGHSSLTQYIQLFLGGFGLEKQDLEELRTWGSKTPGHPENFLTKGVEMTTGPLGQGISSAVGFAMAQRRERGLLDPSAAAGTSPFDHFTYVIASDGDLQEGVSSEASSIAGTQQLGNLIVLWDDNEISIEGDTSIAFTEDTAARYEAYGWDVRTVDWTAGGADGSTYVEDVAALKAEILEAQKVTDKPTFIRLHTVIGWPIPELAGSASVHGAKLGPEGVKGLKEAIGFDPEQQFQVDEDVLAHTRGLAERAAAAKAEWETGYQAWRSANADAAALLDRLRARELPTGFAQAFPSFEADEKGIATRAASGAVLNALAPVMPELWGGSADLAGSNNTSMKGEPSFLPAELSSAEFTGDKFGRTMHFGIREHAMGAILSGISLHGLTRPYGGTFFQFADYMRGAVRLASLMKVPATYVWTHDSIGLGEDGPTHQPVEHLAAYRAIPNLSIVRPADANEAAQAWKALLERDHGPVGLILSRQAMPTFDRTEYAGAENLVKGGYIMKEASAEPAVILIATGSEVQYAAAAQKQLEAAGTPTRLVSMPSVEWFDEQDEEYRESVLPAAVTARVSVEAGIAMPWYRFLGTHGRAVSLEHYGASADAKTLFREFGFTAEAVVEAAKESLTAAGA
>NZ_CP022316.1|WP_089063762.1|28285_29401_-|transaldolase
MAQNTNTQALSDAGVSIWLDDLSRQRMSSGNLQELIDTRNIVGVTTNPSIFQSAISGRSEYDEDINRLTGEGKDVEQIVEVLTTDDVRHAADLFADLHASTHGFDGRVSIEVDPRLAHDTDKTIAQAKHLFAVVDRENVFIKIPATEAGLPAITAAIAEGISINVTLIFSIERYLAVMDAYLTGLERAAKAGKDLAKIHSVASFFVSRVDTEIDGRLETLDTEDALALRGQAGVANAQVAFGKYLEVFASKRFEALQAEGANVQRPLWASTGVKNPEYPDTLYVDSLVADPSVNTMPEKTLEAVADHSEPQASLNAELATSAESVLERLTEAGVDLTDVFAVLEREGVEKFEKAWNELLDTVSESVEAARA
>NZ_CP022316.1|WP_089063761.1|26660_28214_-|glucose-6-phosphate-dehydrogenase
MTDSPTRQTGADAPNPLRDPRDRRLPLIAGPSSMVMFGVTGDLARKKLLPAIYDLTHRGLLPPSFGLVGFGRRDWSHDDFAEYVRKSVSEHSRTGFDESVFEQLRGGLRFVTGTFDDTAAFETLTEVVGELDRTRSTGGNHAFYLSIPPDAFPTVLSQLADSGLNSAENGSWRRAVIEKPFGHDLASARALNDVVEKAFRPEEVFRIDHYLGKETVQNILALRFSNQLYEPLWNANYVDHVQITMAEDIGIGSRAGYYDGIGTARDVIQNHLLQLLALTAMEEPVTFRASDLRAEKEKVLSAVELPEDLASHTSRGQYVGGWQGGEEVRPYLEEDGIPADSTTETFAAMRLDIATRRWAGVPFYLRAGKRLGRRVTEIAVVFKQAPFLPFRSTDTADLGQNAIVIRVQPDEGVTMRFGSKVPGTQMEVRDVTMDFAYGMNFTEESPEAYERLILDMLLGDPPLFPRQKEVELSWKILDPITEYWEQNLDPAPYRPGTWGPDTAHEMLARDGRTWRRP
>NZ_CP022316.1|WP_089063760.1|24948_26664_-|6-phosphogluconolactonase
MITTLTDTTASTINKQMIEMRETFGENTIGRVLTLIIISTGDVEKPLEAAVAASHEHPARVIVVDAEPEVDATGLDAEIRVGRDAGAAEVVILRARGDVLSSLDTLVMPLLLPDAPIVTWWPESAPSSPIHDVLGSMSQRRITDSAACADPLGTLKRLRRGYASGDSDLAWTRLTRWRGLVASAYEVPPVAVPQLVQVSGTIDNPSVALMAGWLTHTLGVDVEVLPPHEDAPDCPGVHSVRLVREDGTIDLTRVDDDSIVMKLPGDDTGQHVTMPRRILPELVTEELRRLDPDEVYGEVLASTYSSIDDAATFATGKPEPRDVVGPDGDAVAAAAASAAAAQLAAALEERPLAHLVLTGGTVGTKTAAALPEALLAAGVDCSRLHLWWGDERYVDHDSADRNEVGVREALLAPLQSSAGLPARHIHVMPSPADGMSLEDAAAWYGQQLDQMGGDEPFRTRGRAFFDVLLLGMGPDGHIASLFPQHPGQRGVGASAIGVTDSPKPPAERISLTWPVLNSSRHVALLVAGAEKADAARDGHGKIDPWRVPASAVRGLESTTWYLDEAAAQSLR
>NZ_CP022316.1|WP_089063769.1|39985_40276_+|hypothetical-protein
MTSQPSGPLPDRSSLQTSAIILIVVGFLCGGTIPAIFGIISLVQLDSDPFTAQKMNKVGWIIFWVMLALLILFAIVYVLFFVVMLGAFTLPFMTGG
>NZ_CP022316.1|WP_157697193.1|40302_40779_+|NUDIX-domain-containing-protein
MATPDFVLSLREHIGHELLWMPGVTALVLNRARTRMLAVRRADDGEWTPVTGIIDPGEEPARAAVREVAEEAMISCRVLRLLDVRTLPPITYPNGDRAQYLDLCFLCEADGGATPFPADGENTAARWFPIDAPPPMNERFTRQLSLALEDHAETRFRR
>NZ_CP022316.1|WP_089063771.1|40775_41393_+|hypothetical-protein
MSAQAPLPGTRVRITLSDRPGDQAVVRVIAAPRRDLAHGGRLSPALAPFADALLVDVSVAGTTLLPGAWVEREVLERGAPIAPTPVTAADLRPPAVIAGSSERAALCWGETVWPLELGGVVAIPDSARAGPHPLSRLRRLVLVAGGRRSEIGLTLWRDPGFEIPWQDVRLLPRAAAWFELAQVPPGMRYADAERAQRVGRARPFS
>NZ_CP022316.1|WP_157697011.1|41424_42357_-|formyltetrahydrofolate-deformylase
MGPVLRVFLEWAHERHCTPPQNAADSSGTETEYVLTVVCAEAPGIVHAISGAILEVEGDITESRQFVSSTTHRYYLRMQVRTASAAQELEAALAPAVERFGLELRIDEVGRPVRTLILGSTTLHCVNDLLFRMESGHLPIEVPLILANHPTLEKLAGFYDVPFEHRSTRGPGAKAAFEDRVREAVAEHDIELVVLARYMQILSPELCAELAGRCINIHHSFLPGFKGANPYRQAHARGVKQIGATAHFVTTDLDEGPIIEQEVLRVDHTRSPEELMAIGQDAEIRTLRQAVAWYAQSRVLLDGSRTIVFR
>NZ_CP022316.1|WP_089063772.1|42399_44604_-|MMPL-family-transporter
MTSPDHPPAGEGPTHRRARASFPRALRVLVPALLILGWLIAAGIGGPYFGRVDEVSSNDRTAYLPDSAAATEVAQRAADFTGAEAIPAILVITSPQEMDEETLASLTDVTEALGERKAVTGEVSPPIPSEDGLAVQVFVPLDPDADLAAAIDGIDAELGTDLPPDLTAYVTGPAGFSADLGAAFAGIDGLLLGVALAAVLVILLIVYRSLLLPLIVLLTSLIALCAALLTIWHLAAADVLLLSGQTQGILFILVIGAATDYSLLYVARYRDELRHTRERGRATLAALRGTIAPVLASGGTVIAGLLCLLLSDLKSNSTLGPVAAIGIGFAMAAALTFLPAVLFATGRVAFWPRRPHYAPNAPATGADPAAHGVWGRIALAVRRRPRRLWLLTAAVLAVGCLGVTQLEADGVPQSDLVLTSSSAREGQAALGEHFPGGSGSPVQVITKDSSLQQVADLLLRQDGIESVSVTAEDSPSGSAPVTADGIQAQGQPGTPAPEPTVVDGDVLVQATLTDAADSAAAEATVREVRADLSADDVDALVGGVTATSIDTNDASLHDRTLIIPVVLVVIMLILMLLLRSLLAPVLLIATTVLSFGTAMGVSALVFDHVFAFPGADPSVPLFGFVFLVALGIDYNIFLMTRVREESLIHGTREGVVRGLSVTGGVITSAGMVLAATFAALGVIPILFLAQIAFIVAFGVLLDTFVVRTLLVPALALDLGKVIWWPSALWRRGRD
>NZ_CP022316.1|WP_089063773.1|44718_45324_+|MarR-family-transcriptional-regulator
MSSSPRGEGDHDPPTVVPSLFSIDSSDPQQELIDRRGLDEQDIAQIDALMAALARLRAAEQELAEASLRYMQLGRTDMRALHVLIVAENTGTLATPGAIAQALGISSASTTKLLDRLEAAGHLRRERHPRDRRAVVVTIEPATRSSAMRTVGATQARRVEAARHLLPAEREVVLGFLEDMAEQISVAGVDWEAPGSGAGSS
>NZ_CP022316.1|WP_089066216.1|45526_46786_+|aspartate-aminotransferase-family-protein
MDTTIFEQHESEIRGYCRAYPTVFASASNARQVDEEGTSYIDFFAGAGVLNFGHNNPAMKEAMIDFLQADGVAHSLDTYTTTKRDFIAKFHEVILAPRGMNHKMQFMGPTGSNAIEAALKLARLATGRREVVAFSHGFHGMTLGSLAATANQAFRQWAGVPLTDVVRLPFETAPGGSTGIADYRAALQDPSSGVTPPAAFLVEPVQAEGGVNVASREWLHEIQDLAREVGALFIIDDIQAAVGRTGGYFSFDGMDLDPDIIALAKGLGGFGTPIAMTLNKPEVDAHWSPGAHTGTFRGQGLSFVAGTVALDYFTDEAFLADVLAKGETMREALEAIAAKHSERGWEVRGRGMMQALDTGDGAFAKRIQQECFERGLLVGPCGSGGRVIKLIPPLTIPEEDLRDGLGLLAQAIDAAAGAP
>NZ_CP022316.1|WP_089063774.1|46785_47994_+|aminopeptidase-P-family-protein
MRLRSDMTFAPEEYQRRIAELRERMAERELDAVIITDPENLMYLTDYQTTGYSFFQALVVPLEADSVMITRALEESNVIARTWVENSRPYPDDGDAILELVSTLRDLRLGDSRVGYERNSYYFPAYQQDRIHDAFGEGLVDCFGIVEEGRIRKSPAEIEVMQLAAYAGEAGMAAGLHTAMAGATENDVAAAITSAMFRAGGEFPAVLPYVASGPRSMIGHSTWEGRMIRPGEHVFLEVGGCYRRYHTAMMRTVVNGALSDSMHSAQELMKQTLAELRALMKPGVTISEIAELTRSRIESNEVGAKLVTRAGYSIGIAFPPSWDEGYIVSLLEGDERELEEGMTFHLLPWMWGVDGDKTVGISDTVHITKDGCESFFTLPADFTVHESSARSVPTGAVFAPRF
>NZ_CP022316.1|WP_089063775.1|48019_49396_+|NAD-dependent-succinate-semialdehyde-dehydrogenase
MAMLTAIDPTTGRVVREVPAATPAEITALIDRSQSAYASWKDTTLAERADVLRRVAAYLREHTEELAPLMTEEMGKPIGEARGEVAKSAWAAEHYAEFGPEYLADEHLDSDATSSYVQYLPLGPVLGILPWNAPFWVAFRFCAPALMAGNTCIMKHDPHVPGCAAALEEVFRKAGAPDGVFQTLLAQTEDVEQAIRDPRVQAVSFTGSDRAGATVASIAASEIKPAVLELGGSDPCIVLADADLAKAAEVSALSRIINAGQSCIAAKRMIVERSVHDEFVELLAAQLRDLVVGDPRDPATKVGPIAREQLREGLHRQVTASVEAGATLVLGGELPAGEGFFYPVTLLTGVQPGMTVCAEETFGPIAVVIAADDAEHALALANDTPYGLGAAIWTETERGVAMARRIEAGQVSVNGIVKSDPRLPSGGIKRSGYGRELGPHGIREFTNAQQVWVGPVRA
>NZ_CP022316.1|WP_089063776.1|49480_50866_+|MmgE/PrpD-family-protein
MTRVHELAEFVYESSYEQLSGAAAEQLRIRVLDTIGVAIAAQAAAPMRAIRSLLADLGGREDATFIGGGRGPIDRVAFYNGALSRYLDFMDSYLAAGETNHPSDNLGAVLAAAESVDASGADLLAALAVCYQVQTRLSDVAPVRARGFDHTVQGAYAAAAGVSRALGLDLDQTQQAISISGTANNALRVTRTGDLSHWKGLAYPNMAKEATFAALLAQRGLTGPAEVFEGNKGLQETITGPFEIDWSREDLEKVRETIVKKHNSEIHSQTALDAALEVRLQDGFLARAIDRVELRTFDVAHSIIGGGEEGDKRSIRTKEEADHSLPWLLAVALLDGQVEPEQYHHERIIADDVQDLMRRVHITPDAGYSARFPREMVADLTVTLADGTVLTAFETAYEGFHTDPLDWDGALRKYRRLALPVVGPEVTEEIAGIVRELERHPVRRLTDALSRAGSTHGEESS

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Crispr_ID: NZ_CP022316_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022316_2

1134720-1134835

Orphan

Consensus_repeat	Method
TCAGTGCTGCGGTGGCCGTCGGTTCTCTGGTGGCGGTCAGTGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022316_2

>merge|NZ_CP022316|2|1134720-1134835|CRISPRCasFinder
TCGGTTCTCTGGTGGCGATCAGTGCTGCGGTGGCCGTCGGTTCTCTGGTGGCGGTCAGTGCTGCGGTGGCCGTCGGTTCTCTGGTGGCGGTCAGTGCTGCGGTGGCCGTCAGTTCT

>NZ_CP022316|2|2|1134720-1134835|CRISPRCasFinder
TCGGTTCTCTGGTGGCGATCAGTGCTGCGGTGGCCGTCGGTTCT	CTGGTGGCGGTCAGTGCTGCGGTGGCCG
TCGGTTCTCTGGTGGCGGTCAGTGCTGCGGTGGCCGTCAGTTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022316.1\|WP_089066297.1\|1140220_1141327_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_CP022316.1\|WP_089064570.1\|1139234_1140224_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP022316.1\|WP_089064560.1\|1120548_1121124_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP022316.1\|WP_089064569.1\|1136649_1137063_-\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|223317
NZ_CP022316.1\|WP_089064564.1\|1129032_1130727_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP022316.1\|WP_157697072.1\|1126640_1127345_-\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|223710
NZ_CP022316.1\|WP_089064566.1\|1131980_1132991_+\|N-acetylglucosamine-kinase	unknown	unknown	gnl\|CDD\|225518
NZ_CP022316.1\|WP_089064575.1\|1148457_1148820_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP022316.1\|WP_089064571.1\|1141512_1142373_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP022316.1\|WP_089066295.1\|1125936_1126644_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223710
NZ_CP022316.1\|WP_089064561.1\|1123727_1125743_-\|redoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|271321
NZ_CP022316.1\|WP_157697073.1\|1148970_1149954_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP022316.1\|WP_089064567.1\|1133155_1134583_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NZ_CP022316.1\|WP_172805691.1\|1137059_1137581_-\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|376809
NZ_CP022316.1\|WP_089064574.1\|1146885_1148187_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270450
NZ_CP022316.1\|WP_089064565.1\|1130858_1131833_-\|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl\|CDD\|235467
NZ_CP022316.1\|WP_172805692.1\|1145090_1145861_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NZ_CP022316.1\|WP_089064573.1\|1145914_1146889_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP022316.1\|WP_089064559.1\|1120009_1120303_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379233
NZ_CP022316.1\|WP_089064563.1\|1127538_1128879_-\|PLP-dependent-transferase	unknown	unknown	gnl\|CDD\|273555

Protein	Function_ID	Function_description	E-value
NZ_CP022316.1\|WP_089066297.1\|1140220_1141327_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	3.91174e-151
NZ_CP022316.1\|WP_089064570.1\|1139234_1140224_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	1.83716e-145
NZ_CP022316.1\|WP_089064560.1\|1120548_1121124_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.39464e-10
NZ_CP022316.1\|WP_089064569.1\|1136649_1137063_-\|CrcB-family-protein	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	9.11918e-18
NZ_CP022316.1\|WP_089064564.1\|1129032_1130727_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	4.69179e-115
NZ_CP022316.1\|WP_157697072.1\|1126640_1127345_-\|HAD-IA-family-hydrolase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	9.71093e-44
NZ_CP022316.1\|WP_089064566.1\|1131980_1132991_+\|N-acetylglucosamine-kinase	gnl\|CDD\|225518	COG2971, COG2971, Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism].	8.29332e-29
NZ_CP022316.1\|WP_089064575.1\|1148457_1148820_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.94022e-25
NZ_CP022316.1\|WP_089064571.1\|1141512_1142373_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	3.17231e-67
NZ_CP022316.1\|WP_089066295.1\|1125936_1126644_-\|HAD-family-phosphatase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	7.32364e-37
NZ_CP022316.1\|WP_089064561.1\|1123727_1125743_-\|redoxin-domain-containing-protein	gnl\|CDD\|271321	cd14951, NHL-2_like, NHL repeat domain of NHL repeat-containing protein 2 and similar proteins. NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.	3.4155e-116
NZ_CP022316.1\|WP_157697073.1\|1148970_1149954_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	4.91012e-06
NZ_CP022316.1\|WP_089064567.1\|1133155_1134583_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	1.20173e-33
NZ_CP022316.1\|WP_172805691.1\|1137059_1137581_-\|CrcB-family-protein	gnl\|CDD\|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	3.10954e-26
NZ_CP022316.1\|WP_089064574.1\|1146885_1148187_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.91746e-111
NZ_CP022316.1\|WP_089064565.1\|1130858_1131833_-\|N-acetylmuramic-acid-6-phosphate-etherase	gnl\|CDD\|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	1.59657e-122
NZ_CP022316.1\|WP_172805692.1\|1145090_1145861_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	9.79256e-76
NZ_CP022316.1\|WP_089064573.1\|1145914_1146889_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.68206e-67
NZ_CP022316.1\|WP_089064559.1\|1120009_1120303_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379233	pfam13518, HTH_28, Helix-turn-helix domain. This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.	1.04902e-07
NZ_CP022316.1\|WP_089064563.1\|1127538_1128879_-\|PLP-dependent-transferase	gnl\|CDD\|273555	TIGR01326, Includes:_O-acetylhomoserine_sulfhydrylase, OAH/OAS sulfhydrylase. This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family].	0

>NZ_CP022316.1|WP_089064567.1|1133155_1134583_+|NAD(P)/FAD-dependent-oxidoreductase
MPDLHDQIPTREKVLIIGAGPAGLAAAAALKALEVPFDLVDRAPHVGGIWNPQREDSPVWPTLEMISSREFTQYEDMLQPVSFPEYLSPTQMAKYLRAYAHRHELTEHFRPRTAVRSARPFDEGVWEVELSTGEVGIYRAVISAHGISEHPHRPAWAADVPSSVRVIHARDWDGADGLEGQRVLVVGSGQSAADISVDAARRALDVRWSMRTGHWVVPRRIAGIPGDVAASREPTVLGGLNAKIAETIIRRAVGHPAEVGLPAPVAPLLEDTVIVSDDVLDRVREGRITPAGDVTGVDADGIVTHLGTGSHAGHLSFAPDLIVLATGYESRADHFPQDLVPRTASGAPDLFLGAFARGRDDLVILGQQRVSGGVLPILVEQADIAAYMLAATRDGSSPALEQFRRVRAGSEVAVPAKPAPAPGGVRGRVEGLLGAQKVTTRGGAVPAHEAEGQLVPQVDRDTLLARLRSVRELFA
>NZ_CP022316.1|WP_089064566.1|1131980_1132991_+|N-acetylglucosamine-kinase
MVDASATGGADGSAAPLLVIAGDIGGTSSRLVLAPLDGAVIAEAEGPGANLRSSGAQAFDHVAAATREVLERGRAALGGRGEIAAVALGISGAGPARAAEVRLAVGERLRELGIETGQVLITDDLHTAFLAGGVGDDGLLVLAGTGAVAVRFRDREAVARRDGMGWLLGDIGSAVWLGRRTLEAVAADLDGRGPRTRLTEEIGAMIDLDLREGRVPPSTTGDPRQDLIRALDEQLPAGAPAALGRFAPVPGRIPEDPVARGILDTAIAHVLDTVQALDPRAELPVVLAGSVLTGAGPIHDEVTEALRAEHRRSSIARTGLPGALLLAREQAGASPP
>NZ_CP022316.1|WP_089064565.1|1130858_1131833_-|N-acetylmuramic-acid-6-phosphate-etherase
MSQPPRDEPTLDVSLVDLSSPTEERNPLSTELDALDARGMVDVILGEDATVAAAVQARAGEIAALVEVCVEAISAGHTVHYLGAGTSGRLAVLDAVELAPTFNADESMVTAHLAGGEGAFLTAVEGAEDSTTAGAELVRDRCVAGDVVIGLAASGRTPFVGGALQAARDAGMPTALISANPQASLAALADHPILLDVGPEVVTGSTRMKAGTAQKLTLNALSTATMVRLGTTFGNLMIDVRPTNAKLVARTVRMLVQASGRSPQHAAAMLEAAGGGVRLALVALLADTEVEAAAEVLEQFPRDARRVGDPAGIRSAVAALDARG
>NZ_CP022316.1|WP_089064564.1|1129032_1130727_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MPAHPPAAATPAAADPSLHLRADGISFSFPDRRVLTDVSLVVPAGRPTGLLGENGSGKSTLLRILAVQLAADTGSCTAPGPVGVLHQELPFGPATSLAEVLADALERSRRLEQALIAAGEALASGDDGPTAAAAHRFDTLLAEATLADIWNADRRAEEVLAGLSLDVLAPTTALGRISGGQRERLALAHLLIARPTSWLLDEPTNHLDDAGAAFLTATIAAHPGPVLIASHDRAFLDEATVAQLDLDPAESPAQAEPGGLTAYTGGFSDYLLARFEARDRWEHRYRTEQEELRALRAAVKDSATVGHVDAAPRTEARASKKFYADRNAAVVSRRLRESRARLARLEQHQVRRPPAELQLTHLPAAASRAASGTVQLAVSEVAVTERLAPVSFSVSAGQRLLVTGSNGSGKSTLLDVIAGSLDPTSGTVDRPRSLLIGHLGQDDVAVPGRTVRRHLREAAGLAGTEDAAVPELFGLVAPRDLDRPLALLSRGQLRRVMLTAVLLDPPELLVLDEPTNHLALLTATRLEAALEGWDGTVLIASHDRWLRRRWQGEVLELSAAGGGG
>NZ_CP022316.1|WP_089064563.1|1127538_1128879_-|PLP-dependent-transferase
MTEQTQKFETLTIHAGQVPDTDAGSRALPIHQTTSFVFPSAQSAADRFALAEAAPIYTRITNPTQAVVEDRVAALEGGAAGLLLASGQSAITLSILNLAGSGDSVAVSPSLYGGSFNLFKHTLSRLGITAQWVQDPTDPESWRAAADETTRAFFVESIPNPKQDIPDIRAIADIAHDIGVPLIVDNTVATPFLLRPLEHGADIVVHSATKFLGGHGTSIAGVIVDGDSFDFAAHAEKYPHFNQPDESYNGLVFAGLPAAFATRARTNLLRDLGPAVSPFNAFLIGQGLETLPLRMERHLENTHQVAAVLEADDRVGPVTWASLDSSPYKATADKYLPRGAGSVLGFVLPGGLEAGKRFVDALTLHSHVANIGDVRSLVIHPASTTHSQLSEEEQRAAGIEPGFVRLSVGIEHIDDILADIEQGLAAAAAGATTATADATATAHATA
>NZ_CP022316.1|WP_157697072.1|1126640_1127345_-|HAD-IA-family-hydrolase
MTSDPVAPPVSPLDQWPPRWSPAAVIFDCDGLLVDTEGQWVALQEEYLARHGAALDPVTRRQITGRAADLVVLAIAEAVGKDPHQVGAELLAEHRGHIGEGLTPLPGALETLRSIAAVRPVAVASNSPRDMLDTKLETLELTELVDVSIAIEDVAEAKPAPDMYLAAARELGADPTDCLGFEDSETGADAARAAGLQLIAVPSIPGQEPCAPRRLTSLDDPVLARWISAWEPRR
>NZ_CP022316.1|WP_089066295.1|1125936_1126644_-|HAD-family-phosphatase
MSAGTPSRAVAAEIPARFAAAFGDWTPQAVVFDCDGLLLDTESIWQLTEDRVVAAHGAVLQDGDQALLHGSTIEVASELIARRAGHAEQAVREDLHREFDRELAAGIRTLPGAAEILQLAGSKVPLACASNSWLDSLEDKLRLGGLRDHFTVLEASDTVERPKPAPDMYAAAARALGAEPSRVLAFEDSGTGARAAREAGLRLIAVPTGGHPAPPADLALTALTDPELRAWITLW
>NZ_CP022316.1|WP_089064561.1|1123727_1125743_-|redoxin-domain-containing-protein
MSTTPDPSTPLTARAHGSALRGRGWLNTGGTELDLETLRGKIVLLDFWTFCCVNCLHVLDELRPLEEKWADELVVIGVHSPKFEFEKDPEALAANIERYEVTHPVIDDPDLLTWSEYGARAWPTLMVLDSHGRIAGNLSGEGHAANLDQLVAQLVAEAEADGSLRRGPAPTVLPERTPQTLRYPSKLTLLPDGRLVVSDAGQHRLVVFQNDGSTVDAVIGTGERGHADGDEGTAQFAEPNGVLALPTEVADEVGYDLLVADTANHRLRAVKVGQDRWLRSRTATEVSTVAGSGSQWMQGEPLPRGEGDARTYALSTPWDLTWSHVLDRAVIAMAGIHQLWTFDPVTGAIMVLAGTTQEGLVDGPAVTSWWAQPSGLDELPDGRIVVADSETSAVRVLDPRTMQVSTLVGEGLFDFGHVDGPAAIARLQHPLAVTALPDGRIAVSDTYNGAIRILEEPATDGAGTATGGITALDGVVSLAGPGDAGGAEAEAGPGEAHVVTVATDLDEPSDAIVGPPVDGIGQLIVVESGLHRITWVPVAKAAERMIDKGAQRSERPVTEVGPGPLTVRVLFTPPAGHKLDDSLGPSTQVTISTTPTSMLTSGAGVDTALERTLELDPAYLEGVLHVSARAASCDADPTIEFPACHMHQQDWGVPIRVVQGAPAHLDLSLLD
>NZ_CP022316.1|WP_089064560.1|1120548_1121124_+|TetR/AcrR-family-transcriptional-regulator
MPKIIGGSLEEHRQRTREKIFAALADLLETQEFETVTFSRIATAAGVGRTAMYNHFPDRESLLVEYAIHETTDYIAQLRAGVSDSATPRDAAIAYVHTQLDLNVSFHVPQTSGGATLSPETAARMRDHVVLIEDVLRTIVTDGVASGDFAADLDVDATVRIINGLLVGSSAKRYSRTALEAFVLRGLGTGS
>NZ_CP022316.1|WP_089064559.1|1120009_1120303_-|helix-turn-helix-domain-containing-protein
MSKNTAIVLSVIEAGMSTSEAAQKFHVSPRWVQILVARYRKGGVEALDPDSRRRPPWEEPARGTTPCAPTESTPTAKSPCATPARCATSASAAPTPD
>NZ_CP022316.1|WP_089064569.1|1136649_1137063_-|CrcB-family-protein
MSAGGFLAAALLVGVGGGLGSVARWGVRVLALRLVAARRGEHLNDEIRPASTVLANLLACFLLGLVVARLGSSGGTAEFFYLMLAVGFCGGLSTLSTAALDVVDLVRRRTFSLALAYLLLSAGSGMAALWLGLVLAS
>NZ_CP022316.1|WP_172805691.1|1137059_1137581_-|CrcB-family-protein
MQTVEMAALRFEEVTESEILDSGPVPHESVPWRIAMLVMAGGTVGAMLRFALSMLSPTVTTPTLVELPWATLWVNLLGCLGLGLLNGVLEVRAPRPWLQPLLGTGLCGGFTSFSAVVLEGSAMIGADFPVLAMTYTAATIVLCLSGIVLGLLGGRRLARWQQARRAADEGGTA
>NZ_CP022316.1|WP_089064570.1|1139234_1140224_-|alpha-ketoacid-dehydrogenase-subunit-beta
MSSTASNLPIAKAITAGLRDAMTADDKVLLMGEDIGPLGGVFRVTDGLHAEFGSQRVVDTPLAEAGIVGTAVGLAVRGYRPVVEIQFDGFVYPAYNQITTQVAKMHNRTSGAVNLPIVIRIPHGGGIGAVEHHSESPEALFAPTAGLRILAPSNAQDAYWMTRQAIECEDPVIMLEPKRRYWVKGDVDPDHRPELSPWQAQVVRPGTDATLLAWGPSMPLALESAQVAAEDGIDLEVIDARSLSPVDFPTIAASVRRTGRLLIAHEAPVLGGLGGEIAARISEQCFYHLEAPVLRVGGYHLPYPPARMEHAYLPDLDRVLDGVDRLLEH
>NZ_CP022316.1|WP_089066297.1|1140220_1141327_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MVQLLAADGTRTPHEQLDAVLEESGLATPERLRGYYRDMVMIRAADLEATSLQRQGQLGLWASALGQEAAQIGAGHAARTQDYLVPTYREHGVAWARGIEPWRLLELFRGISHGGWDPNALRTHPYMIVLGSQAPHAVGYAMGLQRDGVVGTGDPSTDTAVLALFGDGASSEGEVAESFTFAASFQAPVVFYTQNNQWAISVPTSVQSRVPLAQRSRGWGIPSVRVDGNDVLAVLGAVRTALDSARSGNGPMFVEALTYRMAAHTTSDDASRYRPAAEEEEWAAKDPILRLRSHLEQQGEIDQQYVSRCDEEAHDLAMQLHHHIHGMEDPDPVRMFDHPYAEPHPIVDAERAEYLEYIAQFEDEEERA
>NZ_CP022316.1|WP_089064571.1|1141512_1142373_-|MurR/RpiR-family-transcriptional-regulator
MATPVLPRLHSRSEDLQPVQRRIAEVILADPLGAGRLTIDQLAAAAACAQSSVVNFARELGFTGYREFRAELAEEAVRATAREGEHAFPTDIDPTDPLATSVARIAAADARAVRDTVRLLDLAVLEESARALSSSRRILLVGVGASGLAATDLQYKLTRLGFSAQALTSAHDALPAVTALGDQDCLLAISDSGRTTDVLDAVEIAARSGARTIAITGSPVGPLARSCEFVLLTASREPSFRAGATSSRIAQLTIADCLLVAISATLPDAGAEALARTRAALEGRRR
>NZ_CP022316.1|WP_172805692.1|1145090_1145861_-|ABC-transporter-permease-subunit
MSLSLFPFYWMISTAVDTSPLSRGASLLPSGFTLEHFRYVLVDAGFLRYVRVSVIVAVGTVLLSAIVALLSAVAVARFRFRLRTQVLIMVLMVQMVPLEALVIPLFLQARNLHMLNSLLGLIIVYLGFSLAFAIWNLRGFVAAVPRELEEAAYIDGATWFRMFRSILLPLVAPGLVATSVFSFITAWNEFIFALTFMQDSSKYTVGVGLRTFFTQNTADWGSVMAASTIITLPVVIFFVLVQRHLAEGMTAGAVKG
>NZ_CP022316.1|WP_089064573.1|1145914_1146889_-|sugar-ABC-transporter-permease
MSSPSTVDERRRDGADGFIPRTVPLGRRLRRGAAPWLLLAPGLIVLGVLLLWPMLRVLNLSLQDYELRNLLRGDTDYVGLDNYVQVLTDPFLWKTVLPNTVGFALVCVVLTMIVGTVVALFLNSLGTLWRSLSTTAIMVAWAVPALTGTYIFVWLFDAQSGLVISTLDGLGLMEAGSYNWFTNRWTFYGIATLNVVYHGFPFIAVTMLAGLMTVPREHYEAAAMDGATAWGRFWNVTVPTLRPIIAVCVILSTIWDFKVFVQIYLMPGGDGTTRSVMNLGVWSYTQSFAQGEYGMGSTIAVLLTALLLVISVIYIRTLMKEEEL
>NZ_CP022316.1|WP_089064574.1|1146885_1148187_-|sugar-ABC-transporter-substrate-binding-protein
MITRRHVLSAGAAGSAALALAACGGDSGSSGGSGGAVDGEGKTLTMWLMEGTNASADTYIEELKTAFSDATGATLDVQVQPWEGAHDKFVTAMAGGTGPDVAEVGTTWVPEFADAGGLDVLTEDIEAAGLSDGMIEGLVEAGTLDGEMYGMPWYAGVRSILGNRDMLEEAGVNSQPQNWDDLLTMITTLEEHDSDWISFPVPGASIFSATPFIWGAGGEIAENADGAWTATINAPEAVEGLTWYTDLALKHNSSTAAASTWVETEALAEFLQEKVPMFITGSWVPATIREDNPELAEKLVAFTIPAKDSPVAPSFLGGSLMCRFTETQEPELAFELIKLVTTGDFATRWAEETNYFPGTVDAVDEVVAGGDELTKVFATQMIDGGKSVPVTPAWGKIEGAKTMTTLVGTILEGTSVQDAADTAAAEMDGFFSG
>NZ_CP022316.1|WP_089064575.1|1148457_1148820_+|response-regulator-transcription-factor
MAHILFVDDDADLVELVSLRLRSCGHEVTAVGSVDAARNALAAHSDVDLVVVDRTMPGRSGADLLRGLRAEGSTPQVLMLTARDREHGPEDGRTPGAEDCMTEPFTPDELATRIISLLAC
>NZ_CP022316.1|WP_157697073.1|1148970_1149954_+|CPBP-family-intramembrane-metalloprotease
MTSSQTSLHGPRTPVPAERRRVRWRSVLVFGAVAYGLFALCAAPFWVLDEGITHPLYTLVIGAGMFAPTIASVVVAKLVDRTSWRDAVGLRFRGRWKRILLWAPLATLLVLALNLATAVIMVLRGVPGDLTGSTWAAEVSRSMSEQGAEMPTGAAVALVLAISAFGLLLTVVPALGEEIGWRGWLRRELAPLGPWPAIVLGGAIWSLWHLPVTLIGHNYTGQPRWAAVAMFLPASIALHYLFSAITERAGGNPIPAAFAHATLNSTLGVAIGVVATSETASELNWFLDTPMGLTGIVLIAATAFAIMPRTGRGAGRGDQQRTAPEAG

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Crispr_ID: NZ_CP022316_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022316_3

1325626-1325721

Orphan

Consensus_repeat	Method
CCTGTCTCAGCTGTCGCCACGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022316_3

>merge|NZ_CP022316|3|1325626-1325721|CRISPRCasFinder
CCTGTCTCAGCTGTCGCCACGCCCTGCTGATCGCGACAGTTGAAGCAGTCTCGATCTGCGCGGCCCAGCTCATCCTGTCTCAGCTGTCGCCACGCC

>NZ_CP022316|3|3|1325626-1325721|CRISPRCasFinder
CCTGTCTCAGCTGTCGCCACGCC	CTGCTGATCGCGACAGTTGAAGCAGTCTCGATCTGCGCGGCCCAGCTCAT
CCTGTCTCAGCTGTCGCCACGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022316.1\|WP_089064716.1\|1332984_1333734_-\|AzlC-family-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224215
NZ_CP022316.1\|WP_089064710.1\|1322945_1324682_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP022316.1\|WP_157697082.1\|1327082_1328021_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NZ_CP022316.1\|WP_089064706.1\|1316873_1317827_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380141
NZ_CP022316.1\|WP_172805645.1\|1333850_1334324_+\|AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP022316.1\|WP_157697230.1\|1318029_1318833_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP022316.1\|WP_089064713.1\|1329906_1332009_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP022316.1\|WP_089064704.1\|1313406_1314183_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_CP022316.1\|WP_157697231.1\|1318856_1319774_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
NZ_CP022316.1\|WP_089064715.1\|1332665_1332992_-\|AzlD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224601
NZ_CP022316.1\|WP_177348987.1\|1325924_1326962_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022316.1\|WP_172805646.1\|1335364_1338565_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238517
NZ_CP022316.1\|WP_089064714.1\|1332005_1332641_-\|DUF456-domain-containing-protein	unknown	unknown	gnl\|CDD\|377293
NZ_CP022316.1\|WP_089064711.1\|1324891_1325605_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022316.1\|WP_089066307.1\|1312409_1313162_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP022316.1\|WP_089064705.1\|1314328_1316632_+\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|187547
NZ_CP022316.1\|WP_089064709.1\|1319839_1320772_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270225
NZ_CP022316.1\|WP_089064703.1\|1310706_1312413_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_CP022316.1\|WP_089064712.1\|1328017_1329910_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP022316.1\|WP_089064717.1\|1334399_1335071_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417

Protein	Function_ID	Function_description	E-value
NZ_CP022316.1\|WP_089064716.1\|1332984_1333734_-\|AzlC-family-ABC-transporter-permease	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	6.17942e-39
NZ_CP022316.1\|WP_089064710.1\|1322945_1324682_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.98767e-147
NZ_CP022316.1\|WP_157697082.1\|1327082_1328021_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	4.34228e-14
NZ_CP022316.1\|WP_089064706.1\|1316873_1317827_+\|hypothetical-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	1.83597e-06
NZ_CP022316.1\|WP_172805645.1\|1333850_1334324_+\|AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	5.19269e-42
NZ_CP022316.1\|WP_157697230.1\|1318029_1318833_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.02733e-153
NZ_CP022316.1\|WP_089064713.1\|1329906_1332009_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.88333e-119
NZ_CP022316.1\|WP_089064704.1\|1313406_1314183_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	3.1308e-73
NZ_CP022316.1\|WP_157697231.1\|1318856_1319774_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.94214e-67
NZ_CP022316.1\|WP_089064715.1\|1332665_1332992_-\|AzlD-domain-containing-protein	gnl\|CDD\|224601	COG1687, AzlD, Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism].	2.63028e-13
NZ_CP022316.1\|WP_172805646.1\|1335364_1338565_+\|hypothetical-protein	gnl\|CDD\|238517	cd01083, GAG_Lyase, Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. These are broad-specificity glycosaminoglycan lyases which recognize uronyl residues in polysaccharides and cleave their glycosidic bonds via a beta-elimination reaction to form a double bond between C-4 and C-5 of the non-reducing terminal uronyl residues of released products. Substrates include chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, and hyaluronic acid. Family members include chondroitin AC lyase, chondroitin abc lyase, xanthan lyase, and hyalurate lyase.	1.58379e-57
NZ_CP022316.1\|WP_089064714.1\|1332005_1332641_-\|DUF456-domain-containing-protein	gnl\|CDD\|377293	pfam04306, DUF456, Protein of unknown function (DUF456). This family is a putative membrane protein that contains glycine zipper motifs.	1.02219e-18
NZ_CP022316.1\|WP_089066307.1\|1312409_1313162_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	1.67476e-34
NZ_CP022316.1\|WP_089064705.1\|1314328_1316632_+\|HAD-IB-family-hydrolase	gnl\|CDD\|187547	cd05236, FAR-N_SDR_e, fatty acyl CoA reductases (FARs), extended (e) SDRs. SDRs are Rossmann-fold NAD(P)H-binding proteins, many of which may function as fatty acyl CoA reductases (FAR), acting on medium and long chain fatty acids, and have been reported to be involved in diverse processes such as biosynthesis of insect pheromones, plant cuticular wax production, and mammalian wax biosynthesis. In Arabidopsis thaliana, proteins with this particular architecture have also been identified as the MALE STERILITY 2 (MS2) gene product, which is implicated in male gametogenesis. Mutations in MS2 inhibit the synthesis of exine (sporopollenin), rendering plants unable to reduce pollen wall fatty acids to corresponding alcohols. This N-terminal domain shares the catalytic triad (but not the upstream Asn) and characteristic NADP-binding motif of the extended SDR family. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.46901e-57
NZ_CP022316.1\|WP_089064709.1\|1319839_1320772_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270225	cd01004, PBP2_MidA_like, Mimosine binding domain of ABC-type transporter MidA and similar proteins; the type 2 periplasmic binding protein fold. This subgroup includes the periplasmic binding component of ABC transporter involved in uptake of mimosine MidA and its similar proteins. This periplasmic binding domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.84445e-66
NZ_CP022316.1\|WP_089064703.1\|1310706_1312413_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.86433e-56
NZ_CP022316.1\|WP_089064712.1\|1328017_1329910_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.69795e-133
NZ_CP022316.1\|WP_089064717.1\|1334399_1335071_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	5.05131e-12

>NZ_CP022316.1|WP_089064711.1|1324891_1325605_+|hypothetical-protein
MNRPVQRLVVIALALLLVVPLGVMGIGQLLGPRGGDQATESSAVENPENRPTADPAEQPPRPELPRPEEPAGLTTQSAEGAQATLTYLLDSYDFMMSSGDTSVWEDSVDPNCQVCMRFLDNAQVLGEQGGYLVGGAFEVHSTTFSGNGEPPATGTVVAQFTQEESILVDDPHLQANQLASVTGQLIATVAWDGERWRVTDMTIAPPEGAAPSDGGGAGDAGGAGDGGSAGDGGSATG
>NZ_CP022316.1|WP_089064710.1|1322945_1324682_-|ABC-transporter-ATP-binding-protein
MTLLRLVLRALKPYWIWVLLVVLFQIVGVLAALYLPTLNADIIDDGVAKADIPVIWQLGRLMLVISFGNIIALVAANFFAARSAMRVGKDLRSTVFSQVASFSPRELAEFGTPSLITRSTNDVQQVQMLVFFSLNMLVQAPVTGIGGVILALRVEPGMAWLIAVMVPVMLVAVGILIVRAAPLFKQMQGKIDDINSVLREQITGIRVLRAFVREDRERERYAVVNGQLTDLNRRIGLLMILINPIIMFILNVSSVMVLLVAAPRIDAGQMEIGSITAFIAYLMQILIAVMMATFMTMMIPRAMVSAERIWEVLDTETSVHQRTDGVRDLEGPIELTFEDVSFTYPGAERPVLENISFSARAGQSVAIIGGTGAGKTTLINLVPRLMDASEGRVLLNGHDVRDLDARVLWDRVGLVPQRPYLFSGTIASNLRFGNPSADEQELWHALTVAQGRDFVAAMPTELESPIAQGGTNVSGGQRQRLCIARALAAKPSLYLFDDSFSALDLTTDARLRAALVPETREALMLIVAQRVSTITGADLILVLDNGRVVAQGTHAELLESSETYQEIVRSQGVEEEVA
>NZ_CP022316.1|WP_089064709.1|1319839_1320772_-|ABC-transporter-substrate-binding-protein
MMSYRPRRRTLLRAAPLALATGLLAPSLASCTRASERLDAESNTVPEVDLSDIAEVPEIAALVPAAIRERGELINGAALNYAPGEFVGSSGEAVGYDIDILAAIGAVLGLATRTEAAVFAQIIPAVGSTYDLGISSFTVNEERLEAVSMVSYFQAGISYAVKTGNPYDIDPGDLCGKRVALQVGTYQEELSIERSAECREIDQSAYDLLAYTSNSDAATNVAGGKGDILMADSPVTAYAIARSRGTLEAIGEIEESALNGIVVAKDQPELAEALRAALQHLIDSGHMERILAAWGNDAGMIPTSEVNPQP
>NZ_CP022316.1|WP_157697231.1|1318856_1319774_-|ABC-transporter-permease-subunit
MRARAASRPGTWISAVVVAVLALGLVWFLVTNPVLEWGTVATYLLDVKVIQGVGWTLLLTVLSMVLGTAVALTAAIMRRSDNPVLRGVSWAYIFVFRGIPVYTQLVFWGLFTVIVPKIVIGVPFGPELLSFSTRDLLTAFWAAVIGLGLNEGAYLAEIIRSGLNSVDRGQSEASKALGMSNGTILRRIIVPQAMRVIVPPLGNETIGMLKTTSLVLAVPFTLDLTFATNGIANKLFTPIPLLIVAALWYLAITSVLMVGQYYLEKYFGRGFDARTPTTGRGGRSRQAAVNRAGTTPNDPLPEVEL
>NZ_CP022316.1|WP_157697230.1|1318029_1318833_-|ATP-binding-cassette-domain-containing-protein
MPGTDWTPATPPRPVIEVEAVHKSFGDLHVLKACDLTVRAGEVAVLVGPSGSGKSTLLRCINQLEEPTAGRVLIDGEVQGYQSDPLPDGRWQKLPSAQIAAQRSRIGMVFQRFHLFPHLTALGNVMEAPVQVRGLPKAAAEQKARTLLERVGLAERADHYPSELSGGQQQRVAIARALAMDPELMLFDEPTSALDPELVSEVLAVLKDLAADGMTMVVVTHEMGFAREVADQVVFMDEGRILERGTPEQVIDHPESERLQGFLASVL
>NZ_CP022316.1|WP_089064706.1|1316873_1317827_+|hypothetical-protein
MYGPSHVILPASADRPYRPSSQPTRRPPGALHLTPEQLGVARRHEISALGLTQWTMRGALERGELRRIARGWTALPTADAAVVRALTAGYRLTCVDAARLHGLWIPEDTSPERHHLHVYRGGSGGSLPPRMKQHSPRGRSWPETDAVASLPLALAHSLRCCSGETSAILLESAMQRGLLSPAEVQQILEAAPAAVRSRIGTVSSASDSGSETRVVRWLRRRKFHVEQQVHVEGVGFLDAYVGGLFLEIDGKEFHSGESAFGRDRRRDLHAIRHGLQVLRISYDQVWHHWPATQQNILRTIAEVGGFGRRKVAQLAAA
>NZ_CP022316.1|WP_089064705.1|1314328_1316632_+|HAD-IB-family-hydrolase
MSNSTPSADQSASSGGHRDGDRRILLTGVTGFLGQAVLRSLLETTENTRITAVVRPKGSLSGLKRLEQLLRKPVFSSWADAISENAQDSQDGLDGKAVVKAAFDARVSVIEGDLTDMPAIEDPFDVVIHSASSVSFDPPIDVAFRTNVGGAQNLYEALLASGQDPHVIHVSTAYVGGIAKGLRQEGSLRTDVDWRAEYQAALDARTRVDAESRRPETLRSQIRGATLRTGRMGPKAVASASEEARRNWVDERLVDFGRTRAQSVGWTDIYTFTKAMAEQVAEELWAAGGHRVSFVRPSIIESAVQNPYPGWIDGYKVADPLIMAYGRGALPEFPGLADSILDVIPVDFVVNVIVALATQDVSRRGDDAYYQVVSGASNPLPFHEMFTAVREYFVEHPLEDDEGKAIEVPAWTFPAVEMVEQRFRAKELAAKAGATAVAYLPATKRTRAWTSDLHKATSGLTTLRMYIELYRQYTKTEMVFDDANTRALRDELSADFLANHDFDVTGIDWSEYFTKQHLPAVTDLTKAYSRAKSAQRKRSARPAPELKQNENALAVFDLDGTVLATNIVQQYFAVVRATRPRRSWPGEIGGLLAAVPGYLRAEKRDRSELIRTVNRRYKGYRGDELRSLMQGEAGRRIRASVRPEALETIERHRAAGHRTVLVSGALDVLVEPLADLFDEVVATHMDEDSSGVMTGYLATPPLVDEARANWLSKYADLHSADLAASYGYGDSHADASWLELVGTPAAVSPDLGLYGVAKKKRWQILEW
>NZ_CP022316.1|WP_089064704.1|1313406_1314183_-|SDR-family-NAD(P)-dependent-oxidoreductase
MHRALITGGTAGIGAAFARAFAARGASLVLVARDASRLDETAAQLRREYGVEVETLIADLADRAAQQRVADRLEAATEPVDVLVNNAGFSVRASLLEEDISAHDLGFEVMIRAVLKLGGAAGRGMRERGRGWIINVGSVSALVTQNNYSAIKAWVGNYSESLGVQLAGTGVQVTALMPGWVRTEFHDRAGIKGSSIPGVLWLDADRLVEECLRDVARGKPVSIPSLRWKGIAGVLRTTPRGIVARLSALLSHRRSREK
>NZ_CP022316.1|WP_089066307.1|1312409_1313162_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MQSLSARSRGEGWEKPEGELAKYRSRWRSGLRFVLQRVIFRMVVRSAVNPQVVMHRRVKSVRGPFVLVANHTSHVDGPLLALSLPWAQGRLLSTGVATDYWFEHGWPRRFFVRTMLNAFPIDRGGGRKHSGTSRKLLRVGVPILVFPEGGRQSSGQMSSFKPGGAALAISVGVPVIPAAIVGGYEAMPKGRSWPKGRPPVRVVFGEPMISHVDESAVEFSTRIRARVKDLYDEHHDEVLGGAAEDEEGSA
>NZ_CP022316.1|WP_089064703.1|1310706_1312413_-|FAD-binding-oxidoreductase
MSERLSAREVKRHKWWGWGLDSVTFRYDNKPAFPPLAKNKVGVDLDSQQPVEPELSEFEVPPSRLPQELKGELAAVVGEENVLADDEYRVVHSFGRSLPDLFRVRSGDFARLVDAIVYPASEEEVAAVLRLVLEHDLVLIPYGGGSSISGSVTPDLSEQRPVISLNLGRMRDVLEIDDTAGLARVEAGAYGPDLEEQLNAEGWTVGHFPDSFTYSTLGGWAATRSSGMQSDKYGDIEDIVRGLRLIHPDGVAVTKPIPGRDSGPSVHEMILGSEGRLGVITEATVQVHRLAPVRQVIAYMYPDWEHGIRGMHAIARSTDVTPTFTRLSDGPETEFSLSMVKEPSSTKGRIAAKVQDGLFAYLRSQGWDTTEEMSISYVCFEGSKAAVEQQKALVKKIVKRNGGITLGAGPGAIYDQKKFDTPYLRDFLMDYQVFGDVCDTGATWSMLNELHTKAYEAFYAVQEEQGLPGFMFCHMSHSYHAGACLYFTFAFPYSSKEQALEQYYAAKSAVQQTFVDLGSTVSHHHAVGTEHQPWITEDIGEVGVRMVKGLFADNDPGRNLNPGKVTTP
>NZ_CP022316.1|WP_177348987.1|1325924_1326962_+|hypothetical-protein
MPSPPAPLPDTVPWRVFTRAEALRAGVSAERLRRSDLRRLRPGLLARTGWGFTESDIAAAICRTDPGAVVVGASAARMQRIPLPQDEDSWTPEVPVQIAIPGGRRGSDDVVRWRGPVLHDGEVRSTRYRLPVTPDGAALPLAPMRLTTRARTWRDLAPSLSHSWLVVVADHLVRRPRPQLEHGRDAPWCTLEELDRACTGRRAGALRRALEQVRIGADSPQETLLRLALVKAGLPEPALNVPLIGADGLPRHEPDFLWPQYRVCAEYEGKHHNEPAQIERDIARARRVASAGWTEVRLSARDTRHDCADAVRVVREALSARGWGSSADAPPHLRPLGTDDAPRRP
>NZ_CP022316.1|WP_157697082.1|1327082_1328021_-|methyltransferase-domain-containing-protein
MNGTDGASGAADPLHPPVPPISSRDEPRFRDRERKNALAAAFQEQGEDYDRLRPGYPGAVLEAMLAQMPARAAGGEGRAIDLGAGTGKLSWALAERGLSVTAVDTSAAMLETARRGGASLPTPSGTASPAAALATSPAAALATHLAPAEATGLPAGSAELVTVAQAWHWFDAATASAEAARLLAPGGVLALVWNMLDVTIPWVHRLSRIMHAGDIHREDFTPTVGPELELTARSVHQWEDPMPTGDLIDLARTRSYVITAPEERRAKVLANLDWYLHEHLGHAPGDLVGVPYRTDLFLYRAARQSLVGLRGC
>NZ_CP022316.1|WP_089064712.1|1328017_1329910_-|ABC-transporter-ATP-binding-protein
MTAAPAAPAKTESSALGAEATTEESALHTVRRGLALTPNALQGLWITILLAVIATAGKVVVPISVQAILDRGIIEPETPDIAFVAAAAGLAALVLLSTAVCNIVMNRRLFRLAETSLATLRKRAFRHIHDLSLLTQGTEQRGALVSRVTSDVDTVSQFMSFGGIMLVVMSMQLVLATAVMLFYSWPLAIVVWLCYIPILLVMGTLQRRIRARFQLVRTEVGRMLGSVSEALVGSATVRAYGIEARTRGTQTARVRDVRDAQFSVLKPQSASFFLSETADGLATAIVVVVGIVLGTGALGISLPGSDLTAGGVIAFVFLVSLFSQPVRMGIEMLMQAQNAVAGWRRVLGVLDTPADVADPAGAIDPHTGRRDDPVPGARDLPEGLLDIEIRELRYSYPTGPEVLHGLSVDLPARSRIAIVGETGSGKTTFAKLLTRMMDPASGEILIGGIPLHLIPYESLRSRVIMVPQEGFLFDTTIGGNLDYGEPGASEAEMSRALDELGLGTWVQELPEGLDTPVGQRGESLSAGERQLVALARAYLADPDIIVLDEATSAVDPAADVRLQQAIDGLARGRTTITIAHRLSTAERADRIMVLDGGDLVEHGTHDELVDLAGGIYAGLHRSWVAHRSAR
>NZ_CP022316.1|WP_089064713.1|1329906_1332009_-|ABC-transporter-ATP-binding-protein
MTRTAAPSRPRRSTAPAAAPAAPALSARQHPAVLVPGLKRLLKGSWEQRRWFALAVLGATAFALLQIATSAVIGRVTEQVIVPSFQRGEATPALLIGGGLAILGIAVARAVTVMARRVFAAATQFELFGLYRERIAAVYAKVPLLWHRRQATGTLLSSVYADVEATFFAMAPFPFALSTIVMLVYATVVVARIDPVILLVMLALIVLLIILNVLLQRFATPIAMRSQQLRAEVAEIAHESFDGANVVKSLGREDIEEERFNRAADDLREAGIRFGYVRGWFDPLIDALPNLGILAVAVLGAWRIGDGHLTTGQLVEVAYLFTLMSLPIRSFGWVLGDLSRTVVGGGRVQQILDVTEERTYGPDPLPEGPGVLTLDEVTFVYLDDPAQVILGRETRSTDLQVREGHALHGVSLRADPRTGTRVLAVVGATGSGKSTLALVAAGLVHPTSGAVRLDGADLRSLTADALTDDVALVLQQAFVFDETVRWNVTLGDDIDEATVRWALRVAQAEDFVDALPDGLDTELGERGGSLSGGQRQRIALARALARRPRLLILDDATSACDPSVELAILDGIRREMTASTLLLIAYRKSTISLADQVVFLDHGRVEAAGTHEELRGRSEGYRSLVDAYDEAAISHNLLESSGPQPSDGPDPSVAVPAARARTVADAREHHSSSRFRYEDDNGMVDHCQDDSPQDDQEEDR
>NZ_CP022316.1|WP_089064714.1|1332005_1332641_-|DUF456-domain-containing-protein
MDPAPIRGRRPALPPPCILVVNAHAACRGAPATAHPAPPGGPVDSLTVQIIVTVLVGLAYAVGLSGIVVPVLPGTITIVIASLVWAIVIGGWTGWVMFSIVLLLGAIGMTTSYVLTGRRLHAAEVPMWPIYVAIASGIVGIFVIPFVGLPLGFLLGLYICEALRQQDWRKGFTSAWIAMKALGTGILIEFSLAMLSTITFAVAVLVHFVTA
>NZ_CP022316.1|WP_089064715.1|1332665_1332992_-|AzlD-domain-containing-protein
MPETGYLLAVMGIGFAITFALRAAPFVILQPLRDSRAVATMALWMPVGILAILTVSTLRTSLEAGPDRLVPAAIATVVTAVVHLLGGRRTVLSVGLGTATFVVLVNLL
>NZ_CP022316.1|WP_089064716.1|1332984_1333734_-|AzlC-family-ABC-transporter-permease
MPVPAPPVGDLPAHPALPADSTPRTEIATGVRLSFAAGLGMFPLGVAFGVLVMQTGLPWWVAPGLSIALFAGSVELLLVGLMVVGTPLATIALTILLVNFRHVFYAFSFPLRVVRHPLARFYSLYALIDEAYAVTAASPGTWNRFRLLALQASFHSYWVGGGIVGVAIASFLPGRIEGLEYALCALFITLTLDACRSRRQIPSLLLAGLAYASAAVVAPGSALFLGLLVFVALLLGRYQLQRHRERRHA
>NZ_CP022316.1|WP_172805645.1|1333850_1334324_+|AsnC-family-transcriptional-regulator
MDLDDIDRAIIDHLRTDGRLSNVALAEKVHLTPGPCLRRVQRLEAEGVILGYTAQVDPAALDQGFAVFLDVELTAYDRGTVEGFESSMRAFTEVVELYRLFGAPDYFVRVAVADLEAYEHFLTEQVITLPGVSRVASRFAMKVLKSQGPAPVTARRR
>NZ_CP022316.1|WP_089064717.1|1334399_1335071_+|VanZ-family-protein
MNELLRLALVGIAGGLGLFAVILLPAMWLQRRRFGRARPSRLAGVAAICVYTMSLAGLTIAPAYDVAVTCRSRSGGALRLDPFHTAAEVLGMQRGGAGLLELATSFPVLQLLLNMALFLPLGLILRGVFRLDATTSLALAVLLSALIEITQFTGAFGLYPCGVRIADIEDLLANSLGAWIGALLAPLLARWGVPLFAREDHHRGPGGGPESRSGVEDLFRRWF
>NZ_CP022316.1|WP_172805646.1|1335364_1338565_+|hypothetical-protein
MKTPSIGRRGFLAGGTLAAAAGTLPFTLPGATPAAMAAPQDGLEEELASLDAPIYLLETFVPDSFSTDAGSSLEISATHGKVGSHSLQWDHEPGARMRINGDIGYTPRSSGNMDHFSAWVYNETPTDDVLRFEFGRGAEVDAYLDFHLDFTGWRTFWLRYDKDVQGEAQAGLDRISLRAPSTAGTLWIDQVVTNMTMRGDLGHSDMQVPDTYPELESNSNFHWMGVLEFWHQRTDPGFDSSDVTPAEIEDAKLVYDRLLERQRENRDYDSAALDVFEANLDGYDIPELADPDAMGAALRPARPGAFILDKQTEIIPSSYRAAVEEFADTIQLRKVWDETGQPLAQAYDCARRAGDEDAAERAGGLLLRILAHLDDQGWAAGSGQGSLHHVGYQFRSWVKSLLMMEPLLRERELWGQVGSTLEWIAGTGRLLNDFTRKRDRSGMADVMNTYTEGLLSTCFAPGSWEERVGRLRAFKSWNDHVFSYSHGTNGGFKPDGSLYHHVGPYPLYGRDGLVGTTPVATDVAGTAFALDPSAQEVLKQGLHHQLILANVLDYPLSQTGRQQTGTNGIAALIEPFARTGLTRLDGAPGYDEEQAALFLYLLPPDPADWSAFQTETRQLFLEAGIEEASPPNGYWALPYASTGLRREGSWSVTMRTHNRYIWATEIYTNNNSYGRYQTYGQLTVFADTDDEDYVTMLENGVTQPGYDWRFIPGATTKTIPFEQLKQPLSGRTTSLALTDSRFGGSGVLQDKAVVVGMELREHPYYDYSHTARISALMVGDRVIALGSGINNDDADFPTRTTLYQASPELMSAPQEVRSGKNWVTDPTGNGYVVLEGPGITHTLAEQTTPDQTSKKEGTLLMALGYLDHGTSPDDAGYAYTLLVQGGAEATEALAQSMSGEDAPVSILQRDRTAHVVTDAASQITAHVVFEPETALADGSVVRSIDRQAMVLTHPSGDGRATEFSVTDPDLHLYEGRDESAYDEDGTFLGNQNPYEAEWRYQESLKTETTLVLEGRWRVRHARVARELGLSLTMLSSGDTAVTLSTQHGKSVEFSLIQTANPPGNDK

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Crispr_ID: NZ_CP022316_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022316_4

1629819-1629898

Orphan

Consensus_repeat	Method
GGCCGACGCCCCAGCCCCGGCCGACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022316_4

>merge|NZ_CP022316|4|1629819-1629898|CRISPRCasFinder
GGCCGACGCCCCAGCCCCGGCCGACGTCTGAGGTCCGGCGGGCGCCCCGCCGTAGGCCGACGCCCCGGCCCCGGCCGACG

>NZ_CP022316|4|4|1629819-1629898|CRISPRCasFinder
GGCCGACGCCCCAGCCCCGGCCGACG	TCTGAGGTCCGGCGGGCGCCCCGCCGTA
GGCCGACGCCCCGGCCCCGGCCGACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022316.1\|WP_089064911.1\|1612297_1613386_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176218
NZ_CP022316.1\|WP_089064926.1\|1635594_1636293_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP022316.1\|WP_089064916.1\|1625649_1626120_-\|ASCH-domain-containing-protein	unknown	unknown	gnl\|CDD\|119345
NZ_CP022316.1\|WP_089064913.1\|1615036_1616524_+\|FGGY-family-carbohydrate-kinase	unknown	unknown	gnl\|CDD\|198372
NZ_CP022316.1\|WP_089064921.1\|1630557_1631502_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270324
NZ_CP022316.1\|WP_089064920.1\|1629931_1630420_-\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|176867
NZ_CP022316.1\|WP_089064914.1\|1621638_1622358_-\|aquaporin-family-protein	unknown	unknown	gnl\|CDD\|223653
NZ_CP022316.1\|WP_089064929.1\|1638403_1639204_-\|hydroxymethylpyrimidine/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561
NZ_CP022316.1\|WP_089064919.1\|1628623_1629106_-\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|176907
NZ_CP022316.1\|WP_172805696.1\|1637479_1638205_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP022316.1\|WP_089064923.1\|1632210_1632861_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224095
NZ_CP022316.1\|WP_089064922.1\|1631542_1632214_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP022316.1\|WP_089064924.1\|1632857_1633724_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213262
NZ_CP022316.1\|WP_089064915.1\|1624408_1625368_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_CP022316.1\|WP_089064917.1\|1626239_1627322_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022316.1\|WP_089064927.1\|1636378_1637362_-\|glutamate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270408
NZ_CP022316.1\|WP_089064918.1\|1627650_1628523_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl\|CDD\|234823
NZ_CP022316.1\|WP_157697098.1\|1622335_1624273_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223651
NZ_CP022316.1\|WP_089064912.1\|1613751_1614705_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_CP022316.1\|WP_089064925.1\|1634764_1635598_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836

Protein	Function_ID	Function_description	E-value
NZ_CP022316.1\|WP_089064921.1\|1630557_1631502_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.23713e-123
NZ_CP022316.1\|WP_089064926.1\|1635594_1636293_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.61631e-62
NZ_CP022316.1\|WP_089064916.1\|1625649_1626120_-\|ASCH-domain-containing-protein	gnl\|CDD\|119345	cd06553, ASCH_Ef3133_like, ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation.	2.37891e-63
NZ_CP022316.1\|WP_089064913.1\|1615036_1616524_+\|FGGY-family-carbohydrate-kinase	gnl\|CDD\|198372	cd07804, FGGY_XK_like_1, uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases. This subgroup is composed of uncharacterized bacterial and archaeal xylulose kinases-like proteins with similarity to bacterial D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17), which catalyze the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. The presence of Mg2+ or Mn2+ is required for catalytic activity. D-XK exists as a dimer with an active site that lies at the interface between the N- and C-terminal domains. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	0
NZ_CP022316.1\|WP_089064911.1\|1612297_1613386_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176218	cd08256, Zn_ADH2, Alcohol dehydrogenases of the MDR family. This group has the characteristic catalytic and structural zinc-binding sites of the zinc-dependent alcohol dehydrogenases of the MDR family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.	0
NZ_CP022316.1\|WP_089064920.1\|1629931_1630420_-\|polyketide-cyclase	gnl\|CDD\|176867	cd07825, SRPBCC_7, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	1.49486e-58
NZ_CP022316.1\|WP_089064914.1\|1621638_1622358_-\|aquaporin-family-protein	gnl\|CDD\|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	2.19796e-61
NZ_CP022316.1\|WP_089064929.1\|1638403_1639204_-\|hydroxymethylpyrimidine/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	1.25463e-122
NZ_CP022316.1\|WP_089064919.1\|1628623_1629106_-\|polyketide-cyclase	gnl\|CDD\|176907	cd08898, SRPBCC_CalC_Aha1-like_5, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	7.98254e-17
NZ_CP022316.1\|WP_172805696.1\|1637479_1638205_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.12778e-149
NZ_CP022316.1\|WP_089064923.1\|1632210_1632861_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	2.87509e-28
NZ_CP022316.1\|WP_089064922.1\|1631542_1632214_-\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	1.11008e-46
NZ_CP022316.1\|WP_089064924.1\|1632857_1633724_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213262	cd03295, ABC_OpuCA_Osmoprotection, ATP-binding cassette domain of the osmoprotectant transporter. OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	5.00876e-130
NZ_CP022316.1\|WP_089064915.1\|1624408_1625368_+\|transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	2.53182e-75
NZ_CP022316.1\|WP_089064927.1\|1636378_1637362_-\|glutamate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.54758e-79
NZ_CP022316.1\|WP_089064918.1\|1627650_1628523_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl\|CDD\|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	1.67212e-101
NZ_CP022316.1\|WP_157697098.1\|1622335_1624273_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	5.40549e-135
NZ_CP022316.1\|WP_089064912.1\|1613751_1614705_-\|transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.00485e-67
NZ_CP022316.1\|WP_089064925.1\|1634764_1635598_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.29073e-54

>NZ_CP022316.1|WP_089064919.1|1628623_1629106_-|polyketide-cyclase
MADASVLPADRPVPDEIVRSALIHATAERVFAIISEPGWFINDGEYREHTITRQGAVTQVVDPVHGSFQIAVEVREAPYRVRFRWLGGGLGEISDAPNNTVEFIIDPAGTAKRNLVRLTVRERGFAKLGLDDAVRRRNYEENYRGWEQQLGVARTLAEGR
>NZ_CP022316.1|WP_089064918.1|1627650_1628523_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MGRVTEATRIRTVRVREGRLYAGRRGDHVAVEEPLDIRLNGQQLSLTMRTPGHDVELIHGFLHGEGLIAHREDIREARYCDGAVIDDGTGFAQNTYNVMDFTTSRPQLLPLAGRNFSAGSACGVCGAESIDAVRKRSRFVLEHDWQVDPRTILAAARGLDRQQAVFARTGGVHAAALVDLTGELLVVREDVGRHNAVDKVIGWALLEDRLPLRDCFLLVSSRASFEIAQKACMAGIPLLACVSAASSLAVETAEEFGQTLIGFTRTAEDGDGRMNVYTHPERLDLAAAEG
>NZ_CP022316.1|WP_089064917.1|1626239_1627322_-|hypothetical-protein
MARDLTRFHGALLHRSEWISLGLHPRDLASGRFITAFPGYLTLTDHPASFNGLAWALQNSVRPGSVLSHTTAALLWGIPLPWRLEDGVGMLRQPEPEGGAEDPLIPSVRPGSALGSGASLPLLHCRVLPGASSSVGRGVIVHRHPEAATARRGRLLVSSQAETLRELATLLPLWDVVAAVEAVISPDAVHPGETLESLRAEVEARRGAAGTARIRRALELAREGVRSPGESVMRLMLMDAGFPEPEPNLPVEDPRTGKIRYVDLAWASIRFGLEYDGDGHRTTKEQWREDETRRDELAAQGWTLARSHGGDLRQPLRMLLRLQRSAGERGLRVPTERRVRRAARRLAADQPSLRLDGQPS
>NZ_CP022316.1|WP_089064916.1|1625649_1626120_-|ASCH-domain-containing-protein
MVNTAECASFWSDVRREVPDLPTAVPEAWAFGATPAHADELLALVLAGTKTATASSLGDYEEDGDPLPAAGDLSIILDGAGRPRAVLEVTSIQIVPFDQVGADHARAEGEGDRTLRSWRRIHEQFWGEHSARGFAPDMPVVCETFRVVFPAAHRNG
>NZ_CP022316.1|WP_089064915.1|1624408_1625368_+|transcriptional-regulator
MTRESRLEGLYAVARMYYGEERTMESIAGELRVSRSTVSRMLRDAREAELVTISLRPPEAQRVEELARLISRQYGVQVQVVPAVPGDDQRERLRTVTEAGGALLDEMLEPGTTLGIAWGTTMAALLGAVRSRPVPGLRIVQLNGAINTEGSGLTYIATVLARAATRWDATVHQFPVPAFFDYPATREAMWRERSVQRVLATQREATVAVFSVGAFDAEVPSHVYTHNYLTREDLSSLRADGAVGDVCTVFLRADGTYRDIAMNQRGSGTAPDRLLRIPRRLLVASGSRKALPLRAALRAGVATDLVVDEVTARSLVALR
>NZ_CP022316.1|WP_157697098.1|1622335_1624273_-|FAD-dependent-oxidoreductase
MRRSSQVSDQQRSALTPAGRAEHLSRLRAATAEEPLDVLVVGGGVNGAGAAFDATTRGLSVGLVETHDWASGTSSRSSKLMHGGLRYLQMLDFSLVAEALRERDLLLTHTAPHLVKPIKFVFPFFKKVVDRAFIGSGVMLYDAMQSVGRKRAVPMHRHLLHGKMLEVFPGLDGEKAVGALEYYDAQVDDARFVMMLVRSAAERDAAVANYTTVVDYLHEGGRVIGARVRDEETGEEFDIHARQTILAGGVWTQDQQELAGADAGLEVLASKGIHITIARERIPAVPDTGIITQTEKSVLFIIPWDEYWVIGTTDTPWTQDPRDVGATDDDIEYVIEHANEVLQEDLHREDVIGVYSGLRPLLQPVKKSGKDGGSTKVSREHTVMEIEPGLTAIAGGKYTTYRVMAEDVVDFAIKDSQPGRPSLTRSIPVIGAQGHLTLVRDKQEIGRRYGFDEIRMDRLLYRYGALLSDVLALIDEDPDLAAPLEHAPRYLRAEVLYAVRAEGARHLSDVLERRTRLDYETRDRGVAAADEIAALLAPSSAGTGAPPSARSRRTAPSSRRDWPARPRPRIPRPRPGSRAHRRCPPRTDRTPAPAVTRSERVSHHPAGDRLRDDCGRGPHPSPDATGPARMRDRSTRRPHGNHFPV
>NZ_CP022316.1|WP_089064914.1|1621638_1622358_-|aquaporin-family-protein
MATIFLYEIAGTAMLTLLGGGVVANVILGKTKGNGGGWLLINFGWGLAVFAGVWTAYKTGAHINPAVTIGLLANGASEYAPGIAVTFGHTIAYFAAQMIGAFLGAVLAWLAYKNHYDQEKDAGTILGTFSTGPEIRHRGWNLVTEIIATFVLVFIIVMFGRTPHELGPLAVSLLVLSIGASLGGPTGYAINPARDLGPRIAHALLPIPNKGGSDWGYSWVPVVGPLIGGALGGLVSAAF
>NZ_CP022316.1|WP_089064913.1|1615036_1616524_+|FGGY-family-carbohydrate-kinase
MAETASAVLGVDVGTASTKGVLVALDGTILRSTVREHSVQRPAPGHVEMDPEIWWSEFVSIAQELTAPGDATVTAVGVSGMGPCVALTDADGAPVRPAILYGVDTRAEEQIHQLTNVLGREEVLAHCGALLTSQSAGPKISWVAQNEPAAYARARRVFMPASYLAFRLTGEYVMDHISASQSPPLYCLRRQDWHTDWAEHVAPGLELPALRWAGEAAGTVSAEITDLVPGLPAGIPVISGTIDAWAEAVSAGATRPGDLMLMYGTTTFLVATTDEPVASRTLWPTSGLTEGAFSLAGGMAASGAITGWLRDLTGEVEFTDLVIEAEQSEPGANGLVMLPYFSGERSPIADPSARGVVAGLTLSHTRGDLYRAALEAAAYGVRHHLETLEAAGLPISRVTAVGGGAQHDLWPQIVSDVTGLTQQIPRSTVGASYGGARLAAELAHGTDTSGWNPSDHRCIPNPAHRERYDELYRLYRELYPATRDISHALARLQQD
>NZ_CP022316.1|WP_089064912.1|1613751_1614705_-|transcriptional-regulator
MLETSMDMHLLHRAATAYYLDGLRQAEVADRVGVSRPSVSKLLAEARRIGMVRFEVLDVPTVDLVELASLLREVLGIASVRIAPGDQVQRGFRGIGDLLAAELGELEVGAGEVVLISSGETIYAVTGMGGMPQMPGAFIVPTVGGQQEPDPSFQTNETVRRLAERTGAQPRFLFAPALTSPSLWASLQADPGFRSVVDLWDGARAAVVGIGAPYRDRTSLTSVVPRHEPTLENAAGDICLHFFDADGVTLTFPGSEFLVRPPLETLRAIPSTIALAAGREKAPSIRAGAKTGLFTSLVTDVPTAEAVLLEAGVDLPS
>NZ_CP022316.1|WP_089064911.1|1612297_1613386_-|zinc-binding-dehydrogenase
MTDIPTTMQAVVMHGPEDYRLEERPVPTPAADELLIEVAAVGVCASDLKAYAGAAKFWGDENRERWVEPGIIPGHEITGEVVSGSQEALARHGVALGDRIVVEQIVPCEECMYCRRGWYWMCAPHDMFGFKQYDGGMAEYMIVPPLARAHRVSKDIAPQHAAYAEPLSCSMHAVERAELQFDDVAVIAGAGPIGLGAIIGAAHKNPKLVIALDFDDDKLALAKKCGADLTLNPSKVDIYEEIRNLTGGYGADVYIECTGHPSAVPQGLNLLRKLGRFVEYSVFKENVSVDWSIISDDKELDVRGAHLGPHTWPGAIKIIEKGDLPLEEICTHQFGLADFQKALDAVADSAGSSVKVSILPGL
>NZ_CP022316.1|WP_089064920.1|1629931_1630420_-|polyketide-cyclase
MNSNQTHLTVTRTVDVPAKDIFDLLTLPARHHEFDGSGMVRNSDDTERIDKVGEKFVMNMHHEGRGDDYRTHNFVTAYDENKMIGWQPGNEAEDGTAPTEPLGWEWLYELKPQGAGSTEVSLTYDWSKVTDPKLLEHVGFPMIPQEDLEQSLNLLAAAVTKP
>NZ_CP022316.1|WP_089064921.1|1630557_1631502_-|ABC-transporter-substrate-binding-protein
MTIHSTRRHLLGVFGAGSLALGAAACGSSDPFEEGGEEGGGASDGGSGAGTLAIGSQAYYSNEIIAELFAQALEAEGFTVDRQYQIGQREVYMPELESGSLDLLPEYLGNLLQYYDADAPSASPEEIHSALDEALPEGLRVLDFAEASDQDSYTTTSDFASTHSLAAIGDLADVDEALKIAANSEFDVRPYGPEGAKEIYGVDVTVVPVEDSGGPLTVQALLDGDVQLADIYTADPAIAENDLVVLEDPESMILPQNVVPVVSEKIDETAVAAIEGVIAQLSADDLVELNRQSVVDQASSADIAEGWLTEKGLL
>NZ_CP022316.1|WP_089064922.1|1631542_1632214_-|ABC-transporter-permease
MTDSPFLGSLRWLGDATHWTGPDGIPLRTLEHLGYTALGVLVAALLAVPLGLYVGHTGRFKTVAVAAAGAARALPTLGLVTLFALLVGIGLTAPLLSFVILAIPSLLAGAYSAVESADPATVDAARAQGMTEWQILTRVEIPLGMPLLVGGFRGATVQVVATAMLAAYVGSGGLGRFIFQGLGSQNYPQMIAGSLLVIALALVLDLTLLLAQRLSTPRGARAS
>NZ_CP022316.1|WP_089064923.1|1632210_1632861_-|ABC-transporter-permease-subunit
MTWVLENLDVIAGYTGAHLLQALPPILVAFLLSLPLAKLANSRGWLRTSVTTTSSLMYAIPSLPLFVLLPGLIGTGVRSPLNIAVALSLYGLALMVPAAADAFRSVSRDVLGSATAQGYAPRARFFQVELPLAGPVLLAGVRVVAVSTISLVTVGGVLGVPSLGMLFVDGVRRGILAEIAAGIVATVVLALLTDTLLVLLGRAVMPWARRQGVGTP
>NZ_CP022316.1|WP_089064924.1|1632857_1633724_-|ATP-binding-cassette-domain-containing-protein
MIGFENVRKEYPGGTLAVQDFSLEIASHESVVLVGTSGSGKTTLMRMINRMVAPTSGRVHIDGDDVAALDPVQLRRSIGYVMQASGLLPHRTVLDNITTVPVLRGTTKREARARAHELMEIVGLDAALAGRYPSQLSGGQQQRVGVARGLAADPNILLMDEPFGAVDPIVRRELQQELQHLQRDLRKTIVFVTHDIDEAFLLGDRVVILRPGGIIAQVGTPQEILADPADDFVASFVGADRGARTLHVERVDGRDVVVDADGRPAGVLAAGDDRPADAADAVTQQGSS
>NZ_CP022316.1|WP_089064925.1|1634764_1635598_-|amino-acid-ABC-transporter-permease
MSATAGSSTATQVLFDAPGPKGRRRILLLSILSVVLIAALLAGALWQFHANGQLDPNKWVVYLRADYLAFLGHGLWGTLKVTALAAVIAFPFGLLLALARLSRFLLLRSVAVTWIEFFRGIPMLLVVYAFLLALPAFGVTFPRFWMLVIPMILVSSATTAEVFRAGIRAVDIGQHEAADAIGLSRRDSLVYVVLPQAVRLVLPSLILALVTLLKDSTLGYVVSYNELQFQGKTLVSITRYLVQTYLVVSVIYIVINLLLTRIALSLDARMKARAAAS
>NZ_CP022316.1|WP_089064926.1|1635594_1636293_-|amino-acid-ABC-transporter-permease
MDAIRENLPLLAQGIGTTIALTVLGYAFALILGTVLAVARVSPIPPLRGAATVYVEIFRNIPLLSLLILIAFGLPDVGLLLPYFWCGVLGLTLSSAAFVCENVRSGINTVPVGHAEAARSIGLGFFGTLRFVVLPQAFRSMVQPLVNVFIGTVIGSALCSAIAVQEVTWVTQTLNIRYAQAVLMFMIAGAVYLLLSLGGAALGGVIERAVAPGGKDRSSGRAALDVTAGAQA
>NZ_CP022316.1|WP_089064927.1|1636378_1637362_-|glutamate-ABC-transporter-substrate-binding-protein
MTPTTFRPGRRAVVAAAATALPLLGLAACSSDTGDGPDLGGGEGGDEGDGDSVPQADALASGPVAADDVIAASAWATAIKEKGQLVRGGTVANQVFSLASTTGGMPTGFDAGITQLLAKYILGEGGEEKVEYIDTTVETRETMVQNDTVDCVIATYSITAERLEVIDFAGPYYLSGTSIQVRAEDKDTISGPEDLTGLKLVTQANSTGIQAIEENVTDPADVQTLPDNESCVAALKQGRADAYVLDQGVLLGNSAADPDVVVVGEPFVDDPYGIGLSQENEDALDFCNTFLQEIIDSGSWESLWTATVGEVIDGEAPEPPVPGDLPV
>NZ_CP022316.1|WP_172805696.1|1637479_1638205_-|ATP-binding-cassette-domain-containing-protein
MSARGVDKFFGDFQALKNIDLDIHRGEVVALIGASGSGKSTLCRCLNRLETITSGEITIDGERLPEEGRDLTRLRADVGMVFQSFNLFPHLKAIDNVTLGPRRVRGISKPEADQQARELLERVGLADKANSLPTALSGGQQQRVAIARALAMRPKAMLFDEPTSALDPEVINEVLDVMTELAEQGMTMLVVTHEMGFARHVCDRVVYLDQGEIVEQGEPEEFFTAPRTDRARAFLSKILAH
>NZ_CP022316.1|WP_089064929.1|1638403_1639204_-|hydroxymethylpyrimidine/phosphomethylpyrimidine-kinase
MTHVALTIAGSETTGGAGAQTDLKTFHQLGTFGTAALTCIVSFDPKNDWGHRFVPLDPQVIADQIETTTAVHDIDTVKIGMLGTPATIDTVAASLGERSFTNVVLDPVLICKGQEPGAALDTDTALKEKILPLATFVTPNHFEALTLSGMERIDSVEDLTEAARRIHDTYGVIVLAKGGVVLEGEDAVDVFYDGEQTVELRSPKIGEHRVSGAGCTLAAAVTAELAKGATPLEAARTAKAVVTSSIEHRQEGATPFDAVYQGAYRA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	NC_017957	Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence	285111-285138	4	0.857
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	NZ_CP025548	Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence	80807-80834	4	0.857
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	KX576640	Arthrobacter phage RcigaStruga, complete genome	17664-17691	6	0.786
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	MK660714	Arthrobacter phage MrGloopy, complete genome	17602-17629	6	0.786
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	MG210949	Arthrobacter phage Huntingdon, complete genome	17664-17691	6	0.786
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	MK279880	Arthrobacter phage Savage2526, complete genome	17662-17689	6	0.786
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	MG198782	Arthrobacter phage MeganNoll, complete genome	17668-17695	6	0.786
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	KU160662	Arthrobacter phage RAP15, complete genome	17668-17695	6	0.786
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	NC_041940	Arthrobacter phage Glenn, complete genome	17668-17695	6	0.786
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	NZ_CP029452	Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence	1065409-1065436	6	0.786
NZ_CP022316_4	4.1\|1629845\|28\|NZ_CP022316\|CRISPRCasFinder	1629845-1629872	28	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	405235-405262	6	0.786
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	NC_016158	Escherichia phage HK639, complete genome	39720-39747	7	0.75
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	CP000385	Mycobacterium sp. MCS Plasmid1, complete sequence	204074-204101	7	0.75
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	NZ_CP020372	Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence	194900-194927	7	0.75
NZ_CP022316_2	2.1\|1134764\|28\|NZ_CP022316\|CRISPRCasFinder	1134764-1134791	28	NC_008704	Mycobacterium sp. KMS plasmid pMKMS02, complete sequence	11501-11528	7	0.75
NZ_CP022316_4	4.1\|1629845\|28\|NZ_CP022316\|CRISPRCasFinder	1629845-1629872	28	NZ_CP029777	Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed3, complete sequence	350474-350501	7	0.75
NZ_CP022316_4	4.1\|1629845\|28\|NZ_CP022316\|CRISPRCasFinder	1629845-1629872	28	CP054934	Nocardiopsis flavescens strain NA01583 plasmid unnamed1, complete sequence	94677-94704	8	0.714

1. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to NC_017957 (Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence) position: , mismatch: 4, identity: 0.857

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
ccggtggcggtcagcgcttcggtggccc	Protospacer
*.************.*** ********

2. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to NZ_CP025548 (Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.857

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
cgggtggcgatcagtgcttcggtggcgg	Protospacer
* *******.******** ******* *

3. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to KX576640 (Arthrobacter phage RcigaStruga, complete genome) position: , mismatch: 6, identity: 0.786

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
gaggtggcggttactgctgcggtggcgt	Protospacer
  *********.* ************

4. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to MK660714 (Arthrobacter phage MrGloopy, complete genome) position: , mismatch: 6, identity: 0.786

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
gaggtggcggtcactgctgctgtggcgt	Protospacer
  *********** ****** *****

5. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to MG210949 (Arthrobacter phage Huntingdon, complete genome) position: , mismatch: 6, identity: 0.786

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
gaggtggcggttactgctgcggtggcgt	Protospacer
  *********.* ************

6. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to MK279880 (Arthrobacter phage Savage2526, complete genome) position: , mismatch: 6, identity: 0.786

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
gaggtggcggtcactgctgctgtggcgt	Protospacer
  *********** ****** *****

7. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to MG198782 (Arthrobacter phage MeganNoll, complete genome) position: , mismatch: 6, identity: 0.786

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
gaggtggcggtcactgctgctgtggcgt	Protospacer
  *********** ****** *****

8. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to KU160662 (Arthrobacter phage RAP15, complete genome) position: , mismatch: 6, identity: 0.786

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
gaggtggcggtcactgctgctgtggcgt	Protospacer
  *********** ****** *****

9. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to NC_041940 (Arthrobacter phage Glenn, complete genome) position: , mismatch: 6, identity: 0.786

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
gaggtggcggtcactgctgctgtggcgt	Protospacer
  *********** ****** *****

10. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to NZ_CP029452 (Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence) position: , mismatch: 6, identity: 0.786

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
cggagatcggccagtgctgcggtggccg	Protospacer
* *. . ***.*****************

11. spacer 4.1|1629845|28|NZ_CP022316|CRISPRCasFinder matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 6, identity: 0.786

tctgaggtccggcgggcgccccgccgta	CRISPR spacer
gacgaggtccggcaggcgctccgccgga	Protospacer
  .**********.*****.****** *

12. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to NC_016158 (Escherichia phage HK639, complete genome) position: , mismatch: 7, identity: 0.75

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
taactggcgctcagtgctgcggtggcgc	Protospacer
. . ***** ****************

13. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to CP000385 (Mycobacterium sp. MCS Plasmid1, complete sequence) position: , mismatch: 7, identity: 0.75

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
gccgtggcggtccgtgcggcggtggcgc	Protospacer
 . ********* **** ********

14. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to NZ_CP020372 (Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence) position: , mismatch: 7, identity: 0.75

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
ggtctggcggtcggtgccgcggtggcct	Protospacer
    ********.****.*********

15. spacer 2.1|1134764|28|NZ_CP022316|CRISPRCasFinder matches to NC_008704 (Mycobacterium sp. KMS plasmid pMKMS02, complete sequence) position: , mismatch: 7, identity: 0.75

ctggtggcggtcagtgctgcggtggccg	CRISPR spacer
gccgtggcggtccgtgcggcggtggcgc	Protospacer
 . ********* **** ********

16. spacer 4.1|1629845|28|NZ_CP022316|CRISPRCasFinder matches to NZ_CP029777 (Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.75

tctgaggtccggcgggcgccccgccgta	CRISPR spacer
ggagaggtccggcgtgcgccgcgccgcg	Protospacer
   *********** ***** *****..

17. spacer 4.1|1629845|28|NZ_CP022316|CRISPRCasFinder matches to CP054934 (Nocardiopsis flavescens strain NA01583 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.714

tctgaggtccggcgggcgccccgccgta	CRISPR spacer
cacctggtccggtgggcgccccgccgcc	Protospacer
. .  *******.*************.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP022317

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP022316

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection