CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP020828	Listeria monocytogenes strain CFSAN022990 chromosome, complete genome	4 crisprs	DinG,cas3,WYL,casR,cas6,cas8b2,cas7,cas5,cas2,DEDDh,csa3	2	22	5	1
NZ_CP020829	Listeria monocytogenes strain CFSAN022990 plasmid pCFSAN022990, complete sequence	0 crisprs	csa3	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP020828_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020828_1

209958-210109

Unclear

Consensus_repeat	Method
CCGCCACCACCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGAGAC	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP020828_1

>merge|NZ_CP020828|1|209958-210109|CRISPRCasFinder
CCGCCACCACCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGAGACACCGATGCTTCTCGGTTTTAATGCTCCTACTCCATCGGAACCGAGCTCATTCGAATTTCCGCCACCACCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGAGAC

>NZ_CP020828|1|1|209958-210109|CRISPRCasFinder
CCGCCACCACCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGAGAC	ACCGATGCTTCTCGGTTTTAATGCTCCTACTCCATCGGAACCGAGCTCATTCGAATTT
CCGCCACCACCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020828.1\|WP_003722739.1\|214178_215120_-\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|178836
NZ_CP020828.1\|WP_003722729.1\|203332_204046_-\|listeriolysin-transcriptional-regulator-PrfA	unknown	unknown	gnl\|CDD\|223736
NZ_CP020828.1\|WP_003722723.1\|197205_197898_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP020828.1\|WP_014600409.1\|204316_205270_-\|phosphatidylinositol-specific-phospholipase-C	unknown	unknown	gnl\|CDD\|176497
NZ_CP020828.1\|WP_014600414.1\|216816_217377_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_CP020828.1\|WP_003722735.1\|212058_212382_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340321
NZ_CP020828.1\|WP_003722736.1\|212516_212978_+\|YehR-family-lipoprotein	unknown	unknown	gnl\|CDD\|227145
NZ_CP020828.1\|WP_003722726.1\|200215_200524_+\|septation-protein-SpoVG	unknown	unknown	gnl\|CDD\|237321
NZ_CP020828.1\|WP_009930499.1\|213427_214102_-\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|378033
NZ_CP020828.1\|WP_003722725.1\|199787_200096_+\|septation-protein-SpoVG	unknown	unknown	gnl\|CDD\|237321
NZ_CP020828.1\|WP_003725735.1\|213028_213361_-\|putative-heavy-metal-binding-protein	unknown	unknown	gnl\|CDD\|179228
NZ_CP020828.1\|WP_003722740.1\|215413_216037_+\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534
NZ_CP020828.1\|WP_003733150.1\|216125_216710_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP020828.1\|WP_003722731.1\|205511_207101_+\|cholesterol-dependent-cytolysin-listeriolysin-O	unknown	unknown	gnl\|CDD\|366559
NZ_CP020828.1\|WP_003722727.1\|200909_202283_+\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184643
NZ_CP020828.1\|WP_023548120.1\|217491_221031_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NZ_CP020828.1\|WP_003722728.1\|202333_203290_+\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_CP020828.1\|WP_003722732.1\|207431_208964_+\|zinc-metalloproteinase-Mpl	unknown	unknown	gnl\|CDD\|225768
NZ_CP020828.1\|WP_003722724.1\|197894_199103_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|182528
NZ_CP020828.1\|WP_003733966.1\|211117_211987_+\|phosphatidylcholine-phospholipase-C	unknown	unknown	gnl\|CDD\|214813

Protein	Function_ID	Function_description	E-value
NZ_CP020828.1\|WP_003722739.1\|214178_215120_-\|L-lactate-dehydrogenase	gnl\|CDD\|178836	PRK00066, ldh, L-lactate dehydrogenase; Reviewed.	0
NZ_CP020828.1\|WP_003722729.1\|203332_204046_-\|listeriolysin-transcriptional-regulator-PrfA	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	9.59942e-12
NZ_CP020828.1\|WP_003722723.1\|197205_197898_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	7.27113e-121
NZ_CP020828.1\|WP_014600409.1\|204316_205270_-\|phosphatidylinositol-specific-phospholipase-C	gnl\|CDD\|176497	cd00137, PI-PLCc, Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C. This subfamily corresponds to the catalytic domain present in prokaryotic and eukaryotic phosphoinositide-specific phospholipase C (PI-PLC), which is a ubiquitous enzyme catalyzing the cleavage of the sn3-phosphodiester bond in the membrane phosphoinositides (phosphatidylinositol, PI; Phosphatidylinositol-4-phosphate, PIP; phosphatidylinositol 4,5-bisphosphate, PIP2) to yield inositol phosphates (inositol monosphosphate, InsP; inositol diphosphate, InsP2; inositol trisphosphate, InsP3) and diacylglycerol (DAG). The higher eukaryotic PI-PLCs (EC 3.1.4.11) have a multidomain organization that consists of a PLC catalytic core domain, and various regulatory domains. They play a critical role in most signal transduction pathways, controlling numerous cellular events, such as cell growth, proliferation, excitation and secretion. These PI-PLCs strictly require Ca2+ for their catalytic activity. They display a clear preference towards the hydrolysis of the more highly phosphorylated PI-analogues, PIP2 and PIP, to generate two important second messengers, InsP3 and DAG. InsP3 triggers inflow of calcium from intracellular stores, while DAG, together with calcium, activates protein kinase C, which then phosphorylates other molecules, leading to altered cellular activity. In contrast, bacterial PI-PLCs contain a single catalytic domain. Although their precise physiological function remains unclear, bacterial PI-PLCs may function as virulence factors in some pathogenic bacteria. They participate in Ca2+-independent PI metabolism. They are characterized as phosphatidylinositol-specific phospholipase C (EC 4.6.1.13) that selectively hydrolyze PI, not PIP or PIP2. The TIM-barrel type catalytic domain in bacterial PI-PLCs is very similar to the one in eukaryotic PI-PLCs, in which the catalytic domain is assembled from two highly conserved X- and Y-regions split by a divergent linker sequence. The catalytic mechanism of both prokaryotic and eukaryotic PI-PLCs is based on general base and acid catalysis utilizing two well conserved histidines, and consists of two steps, a phosphotransfer and a phosphodiesterase reaction. This superfamily also includes a distinctly different type of eukaryotic PLC, glycosylphosphatidylinositol-specific phospholipase C (GPI-PLC), an integral membrane protein characterized in the protozoan parasite Trypanosoma brucei. T. brucei GPI-PLC hydrolyzes the GPI-anchor on the variant specific glycoprotein (VSG), releasing dimyristyl glycerol (DMG), which may facilitate the evasion of the protozoan to the host#s immune system. It does not require Ca2+ for its activity and is more closely related to bacterial PI-PLCs, but not mammalian PI-PLCs.	1.54768e-114
NZ_CP020828.1\|WP_014600414.1\|216816_217377_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	1.9854e-107
NZ_CP020828.1\|WP_003722735.1\|212058_212382_+\|hypothetical-protein	gnl\|CDD\|340321	pfam17606, DUF5502, Family of unknown function (DUF5502). This is a family of unknown function found in Listeria.	5.76244e-49
NZ_CP020828.1\|WP_003722736.1\|212516_212978_+\|YehR-family-lipoprotein	gnl\|CDD\|227145	COG4808, COG4808, Uncharacterized protein conserved in bacteria [Function unknown].	5.22035e-59
NZ_CP020828.1\|WP_003722726.1\|200215_200524_+\|septation-protein-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	5.03804e-54
NZ_CP020828.1\|WP_009930499.1\|213427_214102_-\|DNA-alkylation-repair-protein	gnl\|CDD\|378033	pfam08713, DNA_alkylation, DNA alkylation repair enzyme. Proteins in this family are predicted to be DNA alkylation repair enzymes. The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.	1.81561e-21
NZ_CP020828.1\|WP_003722725.1\|199787_200096_+\|septation-protein-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	2.92652e-53
NZ_CP020828.1\|WP_003725735.1\|213028_213361_-\|putative-heavy-metal-binding-protein	gnl\|CDD\|179228	PRK01119, PRK01119, putative heavy metal-binding protein.	8.98192e-61
NZ_CP020828.1\|WP_003722740.1\|215413_216037_+\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	2.38585e-63
NZ_CP020828.1\|WP_003733150.1\|216125_216710_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.15404e-10
NZ_CP020828.1\|WP_003722731.1\|205511_207101_+\|cholesterol-dependent-cytolysin-listeriolysin-O	gnl\|CDD\|366559	pfam01289, Thiol_cytolysin, Thiol-activated cytolysin.	1.50399e-178
NZ_CP020828.1\|WP_003722727.1\|200909_202283_+\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184643	PRK14354, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NZ_CP020828.1\|WP_023548120.1\|217491_221031_+\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NZ_CP020828.1\|WP_003722728.1\|202333_203290_+\|ribose-phosphate-diphosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0
NZ_CP020828.1\|WP_003722732.1\|207431_208964_+\|zinc-metalloproteinase-Mpl	gnl\|CDD\|225768	COG3227, LasB, Zinc metalloprotease (elastase) [Amino acid transport and metabolism].	3.90486e-139
NZ_CP020828.1\|WP_003722724.1\|197894_199103_+\|FtsX-like-permease-family-protein	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	4.34799e-62
NZ_CP020828.1\|WP_003733966.1\|211117_211987_+\|phosphatidylcholine-phospholipase-C	gnl\|CDD\|214813	smart00770, Zn_dep_PLPC, Zinc dependent phospholipase C (alpha toxin). This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.	6.00128e-87

>NZ_CP020828.1|WP_003722732.1|207431_208964_+|zinc-metalloproteinase-Mpl
MKSKLICIIMVIAFQAHFTMTVKADSVGEEKLQNNTQAKKTPADLKALPDSCEAKDFYKNFKILDMTKDKLGVTHYTLALSSGGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYVGNPVKEKEIILNSRTKRLVYNIKLIFAEPEVASWIVQVDAETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRTHKGLIRTFDLKHNTDTSFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYEYYKNVHQLESLDGKGGEIDSFVHYGLNCNNAFWDGQEILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGSRDGRIRSIKDPDKYNQAAHMKDYESLPITEEGDWGGVHYNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKSQFTDAKKALQQAAKDLYGEDASKKVAEAWEAVGVN
>NZ_CP020828.1|WP_003722731.1|205511_207101_+|cholesterol-dependent-cytolysin-listeriolysin-O
MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE
>NZ_CP020828.1|WP_014600409.1|204316_205270_-|phosphatidylinositol-specific-phospholipase-C
MYKIYLRRTLVLVLCFILCFFTFPLGGKAYSLNNWNKPIKNSVTTKQWMSALPDTTNLAALSIPGTHDTMSYNGDMTWTLTKPLAQTQTMSLYQQLEAGIRYIDIRAKDNLKIYHGPIYLNASLSGVLETITQFLKKNPKETIIMRLKDEQNSNDSFDYRIQPLINIYKDYFYTTPRTDTSNKIPTLKDVRGKILLLSENHTKKPLVINSRKFGMQFGAPNQVIQDDYNGPSVKTKFKEIVQTAYQASKADNKLFLNHISATSLTFTPRQYAAALNNKVEQFVLNLTSEKVRGLGILIMDFPEKQTIKNIIKNNKFN
>NZ_CP020828.1|WP_003722729.1|203332_204046_-|listeriolysin-transcriptional-regulator-PrfA
MNAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGIAHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN
>NZ_CP020828.1|WP_003722728.1|202333_203290_+|ribose-phosphate-diphosphokinase
MSNEYFDPKLKIFSLNSNRELAEEIAKEVGIELGKSSVTHFSDGEIQINIEESIRGCHVYVIQSTSNPVNQNLMELLIMIDALKRASAATINIVMPYYGYARQDRKARSREPITAKLVANLIETAGATRMITLDMHAPQIQGFFDIPIDHLNAVRLLSDYFSERHLGDDLVVVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVAEVMNIVGNVEGKVCIIIDDIIDTAGTITLAAKALREAGATKVYACCSHPVLSGPAMKRIEESPIEKLVVTNSIALPEEKWIDKMEQLSVAALLGEAIVRVHENASVSSLFE
>NZ_CP020828.1|WP_003722727.1|200909_202283_+|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MSKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLNVDKVVTIVGHGAEKVQEHLAGKSEFVKQDEQLGTAHAVLQAKAELAGKDGVTLVVCGDTPLIEASTMEALLKYHHEKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDATEKEQRISEINTGTYCFDNKALFEALENVSNDNVQGEYYLPDVIKILKDSDEVVAAYRMESFEESLGVNDRIALAEASKLMQRRINENHMRNGVTLVNPESTYIDIDVKIGQDTVIEPGVMLRGKTVIGDDCVVTSGSEIVNSVIGERVHVRTSSIFESKVGDDVQIGPYAHLRPESDIHDHVKIGNYVETKKAVVGEGTKLPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDNVFVGCNSNLIAPVKVGDRAFIAAGSTITKDVPEDALGIARAKQDNKLGYAKHLNHGK
>NZ_CP020828.1|WP_003722726.1|200215_200524_+|septation-protein-SpoVG
MQVTDVRLRRVETDGRMRAIASITLDEEFVVHDIRVIDGNNGLFVAMPSKRGVDGEFRDIAHPINSDTRAKIQEVVLAEYERVGEEEATAVTEEESESVSAE
>NZ_CP020828.1|WP_003722725.1|199787_200096_+|septation-protein-SpoVG
MEITDVRLRRVETDGRMKAISSITIDGEFVIHDIRVIDGNEGLFVAMPSKRTPDGEFRDIAHPINSGTRAKIQEAVLAAYEVADEPAVNEESSADESIVEEN
>NZ_CP020828.1|WP_003722724.1|197894_199103_+|FtsX-like-permease-family-protein
MNVLQSMKMAWKQLKASKLRSFLTMLGIIIGVASVILLVSLGNGVTQEVDDQMGDLGSNLITVVNSSVNPNDKYTYDEVMKYQNIDGVKSVSPELSGQVNATFDYKSSSNKVIGTNDQYKAARSLEMKEGRFLLPIDTEYGQKVAVIGSTVASDLFGFGDPIGETIRLNGMPYKVVGVLKEKGASMMGSSDDQIFIPISSAQRLLKDTNVRTIYVETKSAEDVDFVVNTLESRLAIKFGDEKEQEKNASSAQMGPSYQVINQQEILNAFNTISTTLTTALGAIAAISLVVGGIGIMNIMLVSVSERTREIGIRKALGAKKRAILLQFLIESIVISVCGGVIGIIIGVSGALIFGSVAGISSGITAGTIIFSFVFSLCIGVIFGIAPANKASKLRPIDALRSE
>NZ_CP020828.1|WP_003722723.1|197205_197898_+|ABC-transporter-ATP-binding-protein
MPKPLIDMKNLTKTYTLGGETFKALDDVTFTVEQGEFLSIVGPSGSGKSTLMNMIGCLDVPDEGSYHLDDVDVFKLSDNKLSEIRNKKIGFIFQQFNLLPKLSAFENVELPLIYAGLSVSAREKAAIECLEKVGLLEKRRNLPTQLSGGQQQRVAIARALAGKPQILLADEPTGALDSKTGKEVMGILQELNRAGNTIVMITHDPTIASYGTRSIRIQDGKLFHEEATQA
>NZ_CP020828.1|WP_003733966.1|211117_211987_+|phosphatidylcholine-phospholipase-C
MKFKKVVLGMCLTASVLVFPVTIKANACCDEYLQTPAAPHDIDSKLPHKLSWSADNPTNTDVNTHYWLFKQAEKILAKDVNHMRANLMNELKKFDKQIAQGIYDADHKNPYYDTSTFLSHFYNPDRDNTYLPGFANAKITGAKYFNQSVTDYREGKFDTAFYKLGLAIHYYTDISQPMHANNFTAISYPPGYHCAYENYVDTIKHNYQATEDMVAKRFCSDDVKDWLYENAKRAKADYPKIVNAKTKKSYLVGNSEWKKDTVEPTGARLRDSQQTLAGFLEFWSKKTNE
>NZ_CP020828.1|WP_003722735.1|212058_212382_+|hypothetical-protein
MYIKGRLIFFFVMFVIALCSVLILLIIKISVWKDEPFHLSDAKEIECLGSCEIKNTNQKIHFFSIKENLFEEKGDIAGILNEDEQKVADKSIFIVILDDEKGIANEE
>NZ_CP020828.1|WP_003722736.1|212516_212978_+|YehR-family-lipoprotein
MKMLKKGTAVLFVMIMAVMLVACGDKEETKTYTLSQNGVDSKLTYTYKGDKVTKQTAENTMSYASLGVASKEDAEKMLKATSDKFQGIDGLKEKIEYKDDKAIETLEVDYTKISSEDMNKIPGMSSNGDTSKGISMEESAKMLESQGYKEVSK
>NZ_CP020828.1|WP_003725735.1|213028_213361_-|putative-heavy-metal-binding-protein
MIVTTSPNIEGKQIIEYKKIVFGEVITGVNFMKDIGAGLRNFFGGRSQGYEDELINAREEAIREMEQRAKDIGANAVIGVDIDYEVLGADNGMLMVTASGTAVVIEAQDY
>NZ_CP020828.1|WP_009930499.1|213427_214102_-|DNA-alkylation-repair-protein
MITFDQLDTELQALENPNTIKIFRNHGCPDSLDLYGLKIGDLKKIIRREKLTKNHELAVKLIESNNSDLIYLGLLAINPNKITTEQIEKWNIAFRETWSQLTFGLASIVSKRDDALLFAKTWIESDYDLTKSMGWQIYSEHINNLPEAETLLQRAKETLQTETNRTRYSMNGFIITCGIYKDDLHEKAMEAAKSVGKVHVNLGNTACKVPDAISYIEKARNRTK
>NZ_CP020828.1|WP_003722739.1|214178_215120_-|L-lactate-dehydrogenase
MKDHQKIILVGDGAVGSSYAFACVNLSIGQEFGIIDIDKDRTIGDAMDLSHAVPFSTPKKIYSANYSDCHDADLVVVTAGTAQKPGETRLDLVNRNIKIMKGIVDEVMASGFDGIFLIASNPVDILTYATWKFSGLPKERVIGSGTSLDTARFRMSIADYLKVDARNVHGYILGEHGDTEFPAWSHTTVGGLPITEWISEDEQGAMDTIFVSVRDAAYEIINKKGATFYGVAAALARITKAILNNENAILPLSVYLDGHYGMNDIYIGAPAVVNRQGVRHIVEMNLNDKEKEQMKNSADTLKKVLDDAMKQID
>NZ_CP020828.1|WP_003722740.1|215413_216037_+|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MATTLEVQKRETTQHSEVTRLRSEGKVPGIIYGYKSENVPVSVDSLELIKAVRDNGRNAVFSVTVDGKKLNVLLHEYQVDPLKDVLVHVDLLAVDMNEEVETDVRVVLVGDAPGVKAGGVLQQIIHDVKVSATPEKLPETIELDISSLEIGDVLTTNDLPENKDYVVQAEEEETVVTVSAPRAEEEPTTTEAPEPEAVHGKDEEPVE
>NZ_CP020828.1|WP_003733150.1|216125_216710_+|GNAT-family-N-acetyltransferase
MLDKSVPHISVIMVNHDATNYPEFHLPAGYSFCFYKDGLEEDWCRLQLETGQVLSMDSIRARFETEFGNEKEKLTKRCIFVKAPNGEIIGTAMLWDGNTFGKMESRIHWVAVLDSHGGKGIAKALLSKILGLNKSKFVYLTTQTGSYQAIYLYRKFGFEKYVGKTPENWKTVNFQEEKETAWQIIENKIAEHQA
>NZ_CP020828.1|WP_014600414.1|216816_217377_+|aminoacyl-tRNA-hydrolase
MKLIAGLGNPGKKYERTRHNVGFVVVDELSFRHQTPWKKSKFNGMTSEIIVGGEKMILVKPLTFMNASGECIRPLMDYYNIPIEDVVIVYDDLDLPVGKIRLRQKGSAGGHNGMKSIIQHVKTQEFNRIRVGVSRPLKGEVINYVLGDFPKAEQPDIIAAIQKSADAIEDFAQTPFIEVMNKYNQK
>NZ_CP020828.1|WP_023548120.1|217491_221031_+|transcription-repair-coupling-factor
MKGLQQLIYEQKDIRAVLNALDEKEKAQLVTGLTGSSRALFASVVEGASKRPVVFVTHNLYHAQKLYDDLLSLMDVDRLFLYPADELISSELSISSPELRGQRVEALDFLLSGKPGIVIVPVAGLRKMLPPVSLWKHFNISIVEGEEIDPDVLRQKLVTMGYTMSGMVNTPGEFSVRGGIIDIYPITEEFPIRIELFDTEVDSLRFFDVETQRSTTRVEEFRLLPATEIILDQSYYPDIVKRLEKKMMLTLNELKEQEDKQALIENLEEDLEMLRSGVKPDMFFKYIGLAYPDPASLFDYLPKNTAILLDEFGRILETEESLEREEAEWQTETLSRMETVRDVQVSHSFKKLLEGNHSPKIYLSLFQKQMASMRVSKTTNIVYKQMQQFHGQMNVLKTELESWHKNNYAVVILAPNLERAEKMQQTLTDYDMESTILKKESDVPKYGMVQFVIGTFQNGFELPLAKVAIISETELFNKKIKKVKKRQKLSNAERIQSYSELKVGDYVVHVNHGIARYVGMETLDINGVHKDYLLLVYQGEDKLFIPVDQLDLVQKYVGAEGKSPRLNKLGGAEWKRVKKKVQASVQDIADDLIKLYAEREAEKGYAYSADDEMQREFEEAFPYQETEDQLRSISEIKKDMERPRPMDRLLVGDVGYGKTEVALRAAFKAIMDGKQVAFLVPTTILAQQHFETMKERFQGFPIEIGLLSRFRTKKQQTETLKGMKNGTVDVVVGTHRLLSKDVEYQDLGLLIVDEEQRFGVTHKEKIKQMRSKIDVLTLTATPIPRTLHMSMLGVRDLSVIETPPANRFPVQTYVAEQNNVLVREAIERELARDGQVYYLYNRVESITQKADEISAMVPDARVATAHGQMGESELESVILSFLEGEFDVLVTTTIIETGVDIPNVNTLFVQDADRMGLSQLYQLRGRVGRWNRIAYAYFMYQKDKILREEAEKRLSAIKEFTELGSGFKIAMRDLSIRGAGNILGAQQHGFIDSVGFDLYSQMLKEAIEAKKPKEEQKQIVPVEIDIQADAYIPEYYITDGRQKIEMYKRFRNIETLSELEDLQSDMIDRFGEYPEEVEYLFTMTELKVHALEVGIESVKQEQNKITMLFSESGTAGIRGDIVMQIIGEFGRMVGVGMEGTQLKITINVQNKPLKEWLYQVKSLAEKLRGAMKEKASTEN

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Crispr_ID: NZ_CP020828_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020828_2

523546-524130

Orphan

Consensus_repeat	Method
GATGTAAGTAATTTTGATACNAGTTCNGTAACTNATATG	CRT

7 spacers

The CRISPR arrays of NZ_CP020828_2

>merge|NZ_CP020828|2|523546-524130|CRT
GATTTGAGTGGTCTTGATACTAGTGCGGTAACTACTATGTGGGATATGTTTAACAGCTGTAGGGAACTTGAGGAACTGGATGTAAGTCATTTTGATACAAGTTCAGTAACTAATATGTCTTACATGTTTTATGATAATAGAAATCTTGAGGTGCTGGATGTAAGCAACCTTGATACCAGTTCTGTAACTAATATGTATGCCATGTTTGAAGATTGTACTAGTCTTGAAGAGCTGGATGTAAGTAATTTTGATACGAGTTCAGTAACTGATATGTATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTAGATGTAAGTAATTTCGATACCAGTTCCGCTACTGCAATGGTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTGGATGTAAGTAATTTTAATACGAGCTTAGTAACTGATATGCGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGCGTTAGATGTAAGTAATTTTGATACGAGTTCAGTAACTAATATGGCTGCCATGTTTTCTGATAATGAAAAAGTGGAGAAGCTTGATTTAAGTACCTTTGATACCAGTTCAGTGACTAACATG

>NZ_CP020828|2|1|523546-524130|CRT
GATTTGAGTGGTCTTGATACTAGTGCGGTAACTACTATG	TGGGATATGTTTAACAGCTGTAGGGAACTTGAGGAACTG
GATGTAAGTCATTTTGATACAAGTTCAGTAACTAATATG	TCTTACATGTTTTATGATAATAGAAATCTTGAGGTGCTG
GATGTAAGCAACCTTGATACCAGTTCTGTAACTAATATG	TATGCCATGTTTGAAGATTGTACTAGTCTTGAAGAGCTG
GATGTAAGTAATTTTGATACGAGTTCAGTAACTGATATG	TATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTA
GATGTAAGTAATTTCGATACCAGTTCCGCTACTGCAATG	GTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTG
GATGTAAGTAATTTTAATACGAGCTTAGTAACTGATATG	CGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGCGTTA
GATGTAAGTAATTTTGATACGAGTTCAGTAACTAATATG	GCTGCCATGTTTTCTGATAATGAAAAAGTGGAGAAGCTT
GATTTAAGTACCTTTGATACCAGTTCAGTGACTAACATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020828.1\|WP_009911497.1\|514321_515605_+\|cytosine-permease	unknown	unknown	gnl\|CDD\|271377
NZ_CP020828.1\|WP_031665242.1\|516698_518249_+\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NZ_CP020828.1\|WP_003721239.1\|507307_508063_-\|DUF4866-domain-containing-protein	unknown	unknown	gnl\|CDD\|379782
NZ_CP020828.1\|WP_031671594.1\|527461_527830_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020828.1\|WP_009912377.1\|529524_529872_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020828.1\|WP_003721260.1\|529224_529497_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020828.1\|WP_010989471.1\|506621_507287_-\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|226146
NZ_CP020828.1\|WP_003721245.1\|515605_516706_+\|DUF917-domain-containing-protein	unknown	unknown	gnl\|CDD\|226065
NZ_CP020828.1\|WP_003721242.1\|511489_512437_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP020828.1\|WP_077310202.1\|527826_529203_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368093
NZ_CP020828.1\|WP_047932815.1\|512592_514188_+\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225306
NZ_CP020828.1\|WP_003733213.1\|530275_530518_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020828.1\|WP_014931172.1\|508180_510340_-\|transglutaminase	unknown	unknown	gnl\|CDD\|376628
NZ_CP020828.1\|WP_060588157.1\|525023_525497_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020828.1\|WP_031674415.1\|530600_531578_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004
NZ_CP020828.1\|WP_003721253.1\|525516_526002_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020828.1\|WP_060588155.1\|527176_527461_+\|DUF3130-domain-containing-protein	unknown	unknown	gnl\|CDD\|288220
NZ_CP020828.1\|WP_014931173.1\|510336_511485_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP020828.1\|WP_003733941.1\|526029_526335_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NZ_CP020828.1\|WP_060587965.1\|518895_520434_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|368260

Protein	Function_ID	Function_description	E-value
NZ_CP020828.1\|WP_009911497.1\|514321_515605_+\|cytosine-permease	gnl\|CDD\|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	7.88402e-95
NZ_CP020828.1\|WP_031665242.1\|516698_518249_+\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.01074e-105
NZ_CP020828.1\|WP_003721239.1\|507307_508063_-\|DUF4866-domain-containing-protein	gnl\|CDD\|379782	pfam16160, DUF4866, Domain of unknown function (DUF4866). This family consists of uncharacterized proteins around 250 residues in length and is mainly found in various human gut Firmicute species and abundant in human gut metagenomic datasets. The function of this family is unknown.	1.0462e-120
NZ_CP020828.1\|WP_010989471.1\|506621_507287_-\|DUF1275-domain-containing-protein	gnl\|CDD\|226146	COG3619, COG3619, Predicted membrane protein [Function unknown].	6.55182e-68
NZ_CP020828.1\|WP_003721245.1\|515605_516706_+\|DUF917-domain-containing-protein	gnl\|CDD\|226065	COG3535, COG3535, Uncharacterized conserved protein [Function unknown].	0
NZ_CP020828.1\|WP_003721242.1\|511489_512437_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	7.47241e-102
NZ_CP020828.1\|WP_077310202.1\|527826_529203_+\|hypothetical-protein	gnl\|CDD\|368093	pfam04740, LXG, LXG domain of WXG superfamily. This domain is present is the N-terminal region of a group of polymorphic toxin proteins in bacteria. It is predicted to use Type VII secretion pathway to mediate export of bacterial toxins.	7.82982e-36
NZ_CP020828.1\|WP_047932815.1\|512592_514188_+\|PucR-family-transcriptional-regulator	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	2.29435e-59
NZ_CP020828.1\|WP_014931172.1\|508180_510340_-\|transglutaminase	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	6.06551e-28
NZ_CP020828.1\|WP_031674415.1\|530600_531578_-\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	1.15494e-45
NZ_CP020828.1\|WP_060588155.1\|527176_527461_+\|DUF3130-domain-containing-protein	gnl\|CDD\|288220	pfam11328, DUF3130, Protein of unknown function (DUF3130. This bacterial family of proteins has no known function.	1.03117e-41
NZ_CP020828.1\|WP_014931173.1\|510336_511485_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	7.68035e-53
NZ_CP020828.1\|WP_003733941.1\|526029_526335_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	4.04229e-05
NZ_CP020828.1\|WP_060587965.1\|518895_520434_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|368260	pfam05043, Mga, Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins. This is presumably a DNA-binding domain.	9.14647e-20

>NZ_CP020828.1|WP_060587965.1|518895_520434_+|helix-turn-helix-domain-containing-protein
MREYLDSKSQKKVALLEKIFYAENHTSTQEELLNDLNITYPTLISTIKTINFDIERFGYKAFSIVHSAPNLSYTLKISDNCSIQLIINAYIRESPKFQILETLLLASFPNLQALAKKVHVSYSGIKKEIKELNEELRERNLSISTGNQVEITGDEFSLRIFYAFLFLVTYSGDRWPFSFVQYDEITDLLESCPKEIYRANSIDKGMMIHYYVAMHLLRDRMNCQIDTTRQFKVALYKACTEESKKSESAFIKKVAKQLPNRNYKEITYTTQIILSTIVAFGSYSSIEKMPSFFYMDEQLEEMGFMKLVDFAGERVNDNLSIPFSEREMELLRYSFASINYRYFLLDNLINRFNNIVPGYTDLDRNIRKIHKVNHLEPLISQLVNLKEMRLLKPFEERLASDYLIILDKRIDFSIHTLPIKVTILSTISNETAVFDFMRYFSSYYNLEIINQVDPVVDLYISDFSVSPEVLTSLRINQPIVYVNTRWLESDYVKINDNLAKIARKKFIANKKD
>NZ_CP020828.1|WP_031665242.1|516698_518249_+|hydantoinase/oxoprolinase-family-protein
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTHAMLGTTQCTNAIVERKKLAKVGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYEYDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKNDQELAVQKIIEEELGADIPVSISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIEHAEIYLCQNDGTLMSLNYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDVGGVRTNFRMPDIISIGLGGGSIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAVRLGMAEIGNPELVAHIPTDFAEKAYKKIAEMTEDAIDKMKTSSGSVSLVLVGGGSVIIPDEISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLAGAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV
>NZ_CP020828.1|WP_003721245.1|515605_516706_+|DUF917-domain-containing-protein
MRYLDEQAIENIAIGAAFLGTGGGGDPYIGKMMALTAIKKHGPIKLLSPEEIADDDYFIPAAMMGAPSVLIEKFPKGDEFVRVFEKLGRYVGKEVKGTFPMEAGGVNSMIPIVVAAQLGLPMVDCDGMGRAFPELQMVTFHLDGISATPMAITDEKGNIGIMETIDNKWTERLARVTTVEMGASSLVSLYPCNGAQIKQSSIKNIVTLSEEIGKVIRETSMDEAEKLQKLLDVTHGYHLFEGKITDVVRETRAGFNFGRVKIDGLNKDTNSEVIVHFQNENLVAEKNGEPIAITPDLICMVDLETLMPVTTEALKYGKRVRVMALPADDAWRTDKGIETVGPRYFGYDVDFEPLEELVKKEERRHV
>NZ_CP020828.1|WP_009911497.1|514321_515605_+|cytosine-permease
MTENKTVEQAQSWQSLAFVWTGAMICVPSLLVGGTLISGMPLWEAILIALLGYGVIVVFMIYQGMQSSDLGIPAVSVASQVFGEQGSKKIISILLAIACLGWFGIQANVCGAAFSQFLGIYGINLPVPVSSLIWGVIMLLSAIYGIRILSILNYIAVPILLFVCIYGLVVSLNNGGLAVVENYKPAGSMSFMTGLAITIGSFALGAVIAGDYSQYTKSRKDVVKAAIVGILPSGVLMIAVGAILALTAGTADISVVFTNLGLPVLGIIGLILAAWTTNAVNAFSGGIAIINVFNISEKYHKVAVAIAGGLGTVLAVIGILNHFVPIMSVLSAMVPPVAGVMIASYWIVQKGDKSKWAPVPGVNWLGVTSWLVGAVIAGIPVILTFFPALPQLPNQPLIGIILSLAVYLVGAKVLSGKTNNVENLEGK
>NZ_CP020828.1|WP_047932815.1|512592_514188_+|PucR-family-transcriptional-regulator
MSVKLADLMKLPSLKEARVVSGKSGLSKLVSSISVLEYTEVALLEDDLFDNDEFYGSEIVVSAFVNIREDVEAQCRTIERLHKVGEVALILYYVGIFVPKIDQKLIDFANELDFTIIVMPENEMSLRYSEVIYEVVEAIVKQEMTDTNFVTESLEQISSVRPPQRNIDTTLKILSDRTHSSLVLTDNSFQVINSITWPRTRHWDFERIIEASKQIGEHELVQLHLDERDFYTARKPIFQDGMQAMHLFMMKEKGVLTADVVMQITEVVQVFMNLWGRNYVEISTAELMKAILNDESVKMRRLGKILNVDVSSIKWMWLVKTEEIRNNEQVLAELKSFVASHFQVSLIDLFEDNIVVLLDNSVAQRDRTHTANEFAMMMKEHGIDLKITVCQGMAQTSDVQSAYSLVNEYKNAANAIYANKSIYSLQEIDFAAKCVEIVDRGELAIAEQMRPLKSLEDNDELIETLSVFLLEGESNYNQAAELLFLHKNTIKYRIQRINELLQYPATKIPESYNLYLAVAIRRLLGGNNNNK
>NZ_CP020828.1|WP_003721242.1|511489_512437_-|MoxR-family-ATPase
MSIEPSIKIEEIINEVEKVIVGKRHVVKLSLTALLAGGHVLLEDVPGVGKTMMVRTLSKTIGVSFKRIQFTPDLLPADVTGVSIFNPETRDFEFRPGPVMGNIVLADEINRTAPRTQAALLEGMAENSVTVDGITRKLANPFFVMATQNPIEYEGTYALPEAQLDRFLLKINIGYPTVEEEMQLLTLKQYQDPLDQTQQVVTLSELLDLKNKAKQVFIDDVLKNYIIRLVDATRKHPSVALGISPRGSLAFMQAAQAFALIEGRDYVIPDDIQYLAPYIFTHRLILKSEAYYNEETAESIIASILKNTSVPVEKR
>NZ_CP020828.1|WP_014931173.1|510336_511485_-|DUF58-domain-containing-protein
MLKKRLLLASRWIIMLIIYAGLWTYTLFQGDTASWFLTYFFSFILLLLFLSSIYPLKAWKVNRSFVKNTYHDGDLIDMQVSFTRKSRYPVGYLLFQQKIPATFGKVRARQQVVYPLFKKQFTVTLAGFVGVRGIHSFPPVDVETSDAFGLLERSRQLSSEKSLTIYPTYFPNVLEKISEASPENERNAAYWTLKKNSNLHSLREFSSGDRISLIDWKSSAKSDQLMTREFENSATSRLSVIFYGASHPNFELSLRAAYSFIRKISEENGEIRVTLLGDQTSKFAPAKGTSRLQDISTAFAEIAPVDSLTLQESLDSNLQSGEKILLFTPCMDTMLMQKVTRLTDNKQLQIITFQSEHSKAMDAPAIFLEQASLLGRWEREAK
>NZ_CP020828.1|WP_014931172.1|508180_510340_-|transglutaminase
MKRYLTLIMLFILSVLLISEWIYPFAELTELSTATWIILFITLSLGSFFLRLKYYWTIPLHVVMIIIISGIYYAKGGILAGNWLGSFFQITFNGFRDMVQFRSSDISMDFILIVFLIALWLLSYITTYSILRKQRIMSVLVLTVAYLAVINTFTDYNSNWAIVRTVLEGFLLLHLALASRIAAPNRISADSLKRNGLFYHIFVILLLAVFVFSSLMLPKKAPIFPDPIPTIKNALGINTTRTVGYSEDDTTLGGALKKDNATVFTARAEKGHYWRVESKTVYTGTGWANANSGDVISFSSGDNFPIQLTEQTTGATNTAEISFASSSDYMPYPYGAQAVNGAVDSFSANLTIERVGPVDTIKNYTVQLKTPVYNIEKMQNADFSTLSNAFVSQYTQTPKDLPDRVTKLANKVTEDADSIYDKTKAIERYLSASGTFTYSTDDAKETPRGADYVDQFLFETQIGYCDNFSTSMVVMLRSLGIPARWAKGYTPGEGEKKENDAKTTYTITNNNAHSWPEVFFPGTGWVPFEPTATFSNPENFQEPTTETANKPETPNDSTSTPETPNTPDKTPEQDNGSSSTGETPKKEEPKTETATSNVEIPSWVWWIPAGLVVALLALAIVFRRRIRGYLLLRSLRNSPEFGKTYHRLMKLLASYGYVRESSETLRHFSARVDADLTTSEFSRLTKMYETQLYSKNLTEKVIAAEETQLVQQIIARLTK
>NZ_CP020828.1|WP_003721239.1|507307_508063_-|DUF4866-domain-containing-protein
MTTIFPKEQNVTPLFEQILANPTACRRFKDVFLDNLESYQETRGFEKDDTLFAKIILSAYRQSDVSALLLGVCGRTLFELLRQAFLIPKKLTVDNPFFLTDKEGNFIAKKDDISNREQEKFQEIYQSDLHHSETTIFLVDDDDIVHSYEPDFSISTKRINKKRGILVLYSLPNTLKLEMTESEVYAFIWKTFLHIQEIIPSSRIFYGQETSENADELGVFLPIHHFEKKMLQNIEQVNELVDALREQMVNK
>NZ_CP020828.1|WP_010989471.1|506621_507287_-|DUF1275-domain-containing-protein
MARTRQISESIGLGLLLALAGGFMDAYSYIERGQVFANAQTGNILLFGINISEGNWAIAIQYFWPVVSFTVGIALSEVIHRRDIRRLHWRQLSVLIEAVILIGVAFIPLDHNLIANSLISFVCGIQVESFRKMHGRGVATTMCIGNLRSATQNLCDYFEYKEKQYLHNSFLYFSVILSFIIGAVVGNFFIQLFAQYAILVCAFLQLIAFMMMFIDRESKII
>NZ_CP020828.1|WP_060588157.1|525023_525497_+|hypothetical-protein
MKKKKVVVISLLLLLVSVIGISSYFLFKDKINLLDVDHSAVDWNGKKQKDTSGEENKIAIPGFEKVTLYANETKQAVNFHNPEINDCYFKISLIHPDGSVLWISDLIEPGKGMYSIELEKTLAVGEYENAVLKYECFSLNDQSPLNGSEINLKLVVV
>NZ_CP020828.1|WP_003721253.1|525516_526002_+|hypothetical-protein
MNKLVLSTLSVAAMGMVFFSGGTAYAADKEGNTVVEYSVEGDYTLVVPEKVNLSNDNATEMSVKTINRNLEPGKEVEVTLSSGLSADGEIELQRVGAISDVITSSFKSNNSVVPMANPVIGSFSGYAMEETEVSKIQIGNPQGDKKAGAYQTTLTFTAAFK
>NZ_CP020828.1|WP_003733941.1|526029_526335_+|LPXTG-cell-wall-anchor-domain-containing-protein
MKRKLVLAMVLISFCGMFLLSPERVQASQTVVEVFISEDDLDVSEENIQEIPKKELAASSDKDNKQHMLPKAGDTVTNYTLLGLVLVLIWLIMQRKRKKKE
>NZ_CP020828.1|WP_060588155.1|527176_527461_+|DUF3130-domain-containing-protein
MREIKVDERTFQQHATKLASESTGSYLPLKNGNMAYSKANSIDQLRSALIELVDVVENFQHVTKKDASRLKKMGIAYAKQDQLMGQKINQLEVR
>NZ_CP020828.1|WP_031671594.1|527461_527830_+|hypothetical-protein
MDSAHSQLEQQLQQIKKAKITAETDADQTRRKQNEQDWLEEDSNQLTQEKRVLLDFLRSGWQGEEASGFHRYLEEQQHEESQAWRRDLQDKRTDLDKELQENKDKLHTLETKQATLQKEWSK
>NZ_CP020828.1|WP_077310202.1|527826_529203_+|hypothetical-protein
MSRIDIAELNDFLHGLRSSNAEAKAMIRKIKEAAMDYAQDNSLKGEAVSTSKRYFSSTYKSICQSIIEALDESEERLAQYIREFGSQVDSSPSARIDAEILQEAMAKVSQLQRKEEDLHRQLTAPNTKPDMQQVYAVKSRSVHTQLLKAIEQENILEKYLAFEQSHGQFFSALDELIRATARAVQELLHHVSFNDKTGTYSVPKSAANSLLLMKKARDKARKENDKDPYPKAFEDYTVLAYTYVNDQGETVTMWLLEKDGKRVENKELQDFLEKHGQELDPLLYTNLSGEELERKVNDSWKEGINYLNGQKVSGVSGATLRSSAYVASMKDWTDDAGLTDMALGLGFGIAAARNKVIIPKKTSTAKSSGKDIFNYTDKVNEHMANLDRAVPVQTLKEAIKGGIPMPDPRGSRATMYYSEIYINGKKYNFEVLYDNTTNTIYHFKYDRRPLGPLSAISK
>NZ_CP020828.1|WP_003721260.1|529224_529497_+|hypothetical-protein
MTKKEQLYFLLNGLDNGEIEINNFTNQFMKIFDLEIDYDELSKEEYTILGNVSDMAARFSDSEEDLKLPNVYYSEKQIREEVTRSLEALA
>NZ_CP020828.1|WP_009912377.1|529524_529872_+|hypothetical-protein
MQKDTYNGIRLSVIQLIDSKKENLKENNIKLTIIKNEKDGYVVELDNDKCMAEIVVEEPTYTPYRYISFEVVSLMDGKVKIIYSWYDDETSQWSDIEKELNKGIQFLNNFKTMEQ
>NZ_CP020828.1|WP_003733213.1|530275_530518_+|hypothetical-protein
MKRIILTSTLIVWTIVCIYMSISMVSNNTGIAFPIWLHIILLICFLATSIVNVKKKEYLWSTMLFEGELVVLLSLIIVLV
>NZ_CP020828.1|WP_031674415.1|530600_531578_-|HD-domain-containing-protein
MKMTDPLYGTFEIEPVLAELIQSPLVSRLAHVHQGGSSYLVNPLWDLSRLDHSIGVMLFIRKFGGSLEEQIAGLLHDVSHTAFSHVVDYALDFEEEDYHEQIFEDFVKTSTIPAILEKYGYSFEGIFEDISKWEILEQEAPELCADRIDYTLQDLYRHGKISLAEVEGFLQALVMVNGRLYLANISSAEWFVKQYYSEVIDYFYDPLNVYSYEILAEAMRIAFQQESITTADLRLTDAELLAKLNANSDAREKIQLLASPHLEENEVDFTYHHKKKMRLINPSVLVDGRLIPADELSEKVREMNDWASERSKHGIYIKATKKSKQ

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Crispr_ID: NZ_CP020828_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020828_3

561972-562456

Unclear

I-A

Consensus_repeat	Method
GTTTTAGTTACTTATTGTGAAATGTAAAT	PILER-CR
GTTTTAGTTACTTATTGTGAAATGTAAAT	CRISPRCasFinder
GTTTTAGTTACTTATTGTGAAATGTAAAT	CRT

7 spacers

cas6

The CRISPR arrays of NZ_CP020828_3

>merge|NZ_CP020828|3|561972-562456|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGTTACTTATTGTGAAATGTAAATTTGGATGCAAAAACTTTAATAGCCTCTGCATCAAGGTTTTAGTTACTTATTGTGAAATGTAAATAAATCAACGGGTAAATATTTACTCACAGAGCTTCGTTTTAGTTACTTATTGTGAAATGTAAATCTGGTCCTGTGCTGATGATTGGCGGAAAACTAGTAACAGTTTTAGTTACTTATTGTGAAATGTAAATGTTGAACTAGAAAAACTGCTTGCTTGGGTAGATGAGTTTTAGTTACTTATTGTGAAATGTAAATCATTTCAATAGCTTCCTTTGATGTAACATTAAGCTCAGTTTTAGTTACTTATTGTGAAATGTAAATAGCGGTGTAGACAAAATAACTACAATTAAATTTTCCGGTTTTAGTTACTTATTGTGAAATGTAAATAGAACAGGTGCTGGGTCAACTTGCCCTCCCATTTTTTGTTTTAGTTACTTATTGTGAAATGTAAAT

>NZ_CP020828|3|1|561972-562456|PILER-CR
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTGGATGCAAAAACTTTAATAGCCTCTGCATCAAG
GTTTTAGTTACTTATTGTGAAATGTAAAT	AAATCAACGGGTAAATATTTACTCACAGAGCTTC
GTTTTAGTTACTTATTGTGAAATGTAAAT	CTGGTCCTGTGCTGATGATTGGCGGAAAACTAGTAACA
GTTTTAGTTACTTATTGTGAAATGTAAAT	GTTGAACTAGAAAAACTGCTTGCTTGGGTAGATGA
GTTTTAGTTACTTATTGTGAAATGTAAAT	CATTTCAATAGCTTCCTTTGATGTAACATTAAGCTCA
GTTTTAGTTACTTATTGTGAAATGTAAAT	AGCGGTGTAGACAAAATAACTACAATTAAATTTTCCG
GTTTTAGTTACTTATTGTGAAATGTAAAT	AGAACAGGTGCTGGGTCAACTTGCCCTCCCATTTTTT
GTTTTAGTTACTTATTGTGAAATGTAAAT

>NZ_CP020828|3|2|561972-562456|CRISPRCasFinder
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTGGATGCAAAAACTTTAATAGCCTCTGCATCAAG
GTTTTAGTTACTTATTGTGAAATGTAAAT	AAATCAACGGGTAAATATTTACTCACAGAGCTTC
GTTTTAGTTACTTATTGTGAAATGTAAAT	CTGGTCCTGTGCTGATGATTGGCGGAAAACTAGTAACA
GTTTTAGTTACTTATTGTGAAATGTAAAT	GTTGAACTAGAAAAACTGCTTGCTTGGGTAGATGA
GTTTTAGTTACTTATTGTGAAATGTAAAT	CATTTCAATAGCTTCCTTTGATGTAACATTAAGCTCA
GTTTTAGTTACTTATTGTGAAATGTAAAT	AGCGGTGTAGACAAAATAACTACAATTAAATTTTCCG
GTTTTAGTTACTTATTGTGAAATGTAAAT	AGAACAGGTGCTGGGTCAACTTGCCCTCCCATTTTTT
GTTTTAGTTACTTATTGTGAAATGTAAAT

>NZ_CP020828|3|2|561972-562456|CRT
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTGGATGCAAAAACTTTAATAGCCTCTGCATCAAG
GTTTTAGTTACTTATTGTGAAATGTAAAT	AAATCAACGGGTAAATATTTACTCACAGAGCTTC
GTTTTAGTTACTTATTGTGAAATGTAAAT	CTGGTCCTGTGCTGATGATTGGCGGAAAACTAGTAACA
GTTTTAGTTACTTATTGTGAAATGTAAAT	GTTGAACTAGAAAAACTGCTTGCTTGGGTAGATGA
GTTTTAGTTACTTATTGTGAAATGTAAAT	CATTTCAATAGCTTCCTTTGATGTAACATTAAGCTCA
GTTTTAGTTACTTATTGTGAAATGTAAAT	AGCGGTGTAGACAAAATAACTACAATTAAATTTTCCG
GTTTTAGTTACTTATTGTGAAATGTAAAT	AGAACAGGTGCTGGGTCAACTTGCCCTCCCATTTTTT
GTTTTAGTTACTTATTGTGAAATGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020828.1\|WP_003733192.1\|555847_556450_+\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223865
NZ_CP020828.1\|WP_033920547.1\|562847_563426_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020828.1\|WP_003721297.1\|563533_564214_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_CP020828.1\|WP_069007931.1\|567858_569289_-\|CapA-family-protein	unknown	unknown	gnl\|CDD\|225399
NZ_CP020828.1\|WP_003721290.1\|556961_557360_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020828.1\|WP_003721293.1\|559079_559373_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NZ_CP020828.1\|WP_031644460.1\|570577_571300_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CP020828.1\|WP_003733190.1\|560798_561734_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_CP020828.1\|WP_069007934.1\|553024_553675_+\|TalA-family-protein	unknown	unknown	gnl\|CDD\|223254
NZ_CP020828.1\|WP_003733191.1\|556477_556945_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129
NZ_CP020828.1\|WP_003721291.1\|557370_558021_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NZ_CP020828.1\|WP_003721294.1\|559387_560659_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CP020828.1\|WP_003721298.1\|564238_564598_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131113
NZ_CP020828.1\|WP_010989498.1\|553783_555844_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP020828.1\|WP_069007932.1\|564604_565063_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378956
NZ_CP020828.1\|WP_003721303.1\|569409_570225_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_CP020828.1\|WP_049961575.1\|571774_572500_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|273848
NZ_CP020828.1\|WP_033920546.1\|565444_567280_+\|lmo0514-family-class-1-internalin	unknown	unknown	gnl\|CDD\|380190
NZ_CP020828.1\|WP_069007933.1\|558017_559064_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_CP020828.1\|WP_003721301.1\|567380_567812_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180

Protein	Function_ID	Function_description	E-value
NZ_CP020828.1\|WP_003733192.1\|555847_556450_+\|SIS-domain-containing-protein	gnl\|CDD\|223865	COG0794, GutQ, Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane].	1.15952e-75
NZ_CP020828.1\|WP_003721297.1\|563533_564214_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	7.71833e-60
NZ_CP020828.1\|WP_069007931.1\|567858_569289_-\|CapA-family-protein	gnl\|CDD\|225399	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane].	2.2626e-101
NZ_CP020828.1\|WP_003721293.1\|559079_559373_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	3.06007e-27
NZ_CP020828.1\|WP_031644460.1\|570577_571300_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.57817e-31
NZ_CP020828.1\|WP_003733190.1\|560798_561734_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	1.26262e-153
NZ_CP020828.1\|WP_069007934.1\|553024_553675_+\|TalA-family-protein	gnl\|CDD\|223254	COG0176, MipB, Transaldolase [Carbohydrate transport and metabolism].	1.36452e-61
NZ_CP020828.1\|WP_003733191.1\|556477_556945_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	2.76446e-37
NZ_CP020828.1\|WP_003721291.1\|557370_558021_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	4.74405e-108
NZ_CP020828.1\|WP_003721294.1\|559387_560659_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	7.01085e-178
NZ_CP020828.1\|WP_003721298.1\|564238_564598_-\|hypothetical-protein	gnl\|CDD\|131113	TIGR02058, lin0512_fam, conserved hypothetical protein. This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N-terminus. [Hypothetical proteins, Conserved].	5.62162e-67
NZ_CP020828.1\|WP_010989498.1\|553783_555844_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	5.36772e-80
NZ_CP020828.1\|WP_069007932.1\|564604_565063_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	1.00447e-12
NZ_CP020828.1\|WP_003721303.1\|569409_570225_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.01016e-50
NZ_CP020828.1\|WP_049961575.1\|571774_572500_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.25366e-25
NZ_CP020828.1\|WP_033920546.1\|565444_567280_+\|lmo0514-family-class-1-internalin	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	6.04732e-120
NZ_CP020828.1\|WP_069007933.1\|558017_559064_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	0
NZ_CP020828.1\|WP_003721301.1\|567380_567812_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.03126e-27

>NZ_CP020828.1|WP_003733190.1|560798_561734_+|ribose-phosphate-pyrophosphokinase
MAGKMKLFSVTSERPLATKIADYLDIPLCEVELQKFSDGEVKINIEESIRGTNAYVVQSMNSNVNERLMELLIMVDALKRASVHSINIIMPYYGYARQDRKARSREPITAKLMANLIQRAGANRLITVDLHAAQIQGFFNIPIDHLSAIPLIGDYLIENYGEKDVVVVAPDHSGVVRARRIADRLNAPIAILNRKPRPHEDEIMSVIGDVKGKVAIVVDDIIDTGVRATTSADILLEKGAVEVIACATHSVMAGNATERLQNSNIKEVITSDSIDLPEDKQFDKLTTISIGRILGRAIEGVQENRSLHPLF
>NZ_CP020828.1|WP_003721294.1|559387_560659_+|PTS-galactitol-transporter-subunit-IIC
MDIILDFFKYIIGLGVTVMMPIIITILGVIFRKKISVAFKAGLTVGVGFVGLGVITSLMLTTITPVTKALVENYNFKLTATDIGWGVGSSLAWGTEVVPFVFVAIIATNILMIAFKWTKTMDVDIWNYWQPLFIASALYLTTGSMIIAVLSSIINMAIIFKIADWTQKDVEDVLGLEGISLPQIQTTGWALVGYPMNWLLGKIPGVRKINWSTEKVQSRLGIFGEPMLMGLIIGGGLAAIAQMPLSQVLQTGVTIAASLVLIPRMVSLLMDGLTVISEAAHEFMEKRFPGRELFIGLDSAVGIGHPFVLSLGLLMIPITLILAFILPGNKVLPLADLTALPFYMIFAIVPSKGNLFRGIFTGIVIVIITLYLSGAAAPLMTELAGQIGYNIPKDAVEVTSLAVGTQWYTWIVYYGLHWFGGIL
>NZ_CP020828.1|WP_003721293.1|559079_559373_+|PTS-sugar-transporter-subunit-IIB
MKKKRIYVCCGTGIATSTVISKKVRAVLDEKRIPYEISQCTVQEVASKVSTSKPDIIVSSTTVTGDVGDVPVVIGRSFLTGLKKQETIDEILAILQD
>NZ_CP020828.1|WP_069007933.1|558017_559064_+|galactitol-1-phosphate-5-dehydrogenase
MKALKLYGKRDLRYEEADMPTIEEPDDVILKVKTVGICGSDISRYSKLGPYVPGMVWGHEFSGEVIEVGSEVTDIEIGDRAAGCPALYCGECEYCKKGEFARCRKLTVIGARHPGAYAEYIKLPAENVVKIPDELDYEAAALVEPSAVVVHGFYHTKLQAGDDVVVVGSGNIGLLAIQWAKVFGARRVIAIDVDDKKLALAKEVGADVVINSLKEDPLEVVAAHTDGLNADLVVEAAGSPITSAQVFAYAKKGGGVVFLGIPYVDVTIERFYFEKIVRSELTVWGSWNAISAPFPGKEWQTTIHFLANKQINIEPMITHRLSLAEGPEVFERIYERNEFFGKVLFFPE
>NZ_CP020828.1|WP_003721291.1|557370_558021_+|ribulose-phosphate-3-epimerase
MAKIVPSVFGADIGRINEQLQVLEKNDIDLLHVDMMDGSFVPNIAFGPDQIKMMKKGTKLQFDVHMMVYEPDRYIPRLVEAGAHMITVHQEATTHLHRTIQLIKSYGVRAGVVLNPGTPPSTLEYVLDDIDCILLMTVNPGLGGQKFFQSSLEKIRKTKAYIGNRPIQIEVDGGVNDELAKECTLAGADLIVVGSYLFEGDIEANLEKLAKGVLTE
>NZ_CP020828.1|WP_003721290.1|556961_557360_+|hypothetical-protein
MGSFFASFVDWLIGSPGRFVVNLIEDNMLIFMVVVMIYATTILYAKWTLAYYLPKKMSQLAEMKTWELDELYAAWQTEKKALPWYILVPSRNEFWVKSARNAPESTKLLHFSQQKLKLSDKEKLQKIIEIQS
>NZ_CP020828.1|WP_003733191.1|556477_556945_+|PTS-sugar-transporter-subunit-IIA
MDVLEYFKEEMVRFSNEQNKEKLLAEMAEQLCEVGAVKPSYKDAVIKREKVFPTGLLTAHAGVAIPHTDSEHVIRPVVAVRILKKPVSFIEMASDNEAIDVRIVFMMALRSADEQLDMLQTLIQLIQDEEVMTTLLKAQETGDVLSAIEHFSKNN
>NZ_CP020828.1|WP_003733192.1|555847_556450_+|SIS-domain-containing-protein
MDKQAILNNIHQTWQEEANAISRLPEVTSEEALVKTVEKIAECTGKIVVAGCGTSGVAAKKLVHSFNCIERPAVFLTPSDAVHGTLGVLQKEDILILISKGGNTGELLNLIPACKTKGSTLIGVTENPDSVIAKEADIFFPVSVSKEPDPFNMLATASTMAVIASFDAVIVCLMTYMNYTKEQFSVIHPGGAVGNKLLNK
>NZ_CP020828.1|WP_010989498.1|553783_555844_+|BglG-family-transcription-antiterminator
MYLDNRSKTLFQEVIKNPNITNKQLEVKYKLSRYQISYSFQKVNEWLKWKNYPEVKRSKNGRFILEPELTALFSEKETRDPSVEYLPSENERANLILLMLLTSKEELSLAHFTTKIQVSKNTILRDLKVAQKLLPKETTVTYSRASGYQLAGSEWELRKVLTQVVSSVKEMFRGEHYFLSYSGIEKVQLMEIRRTLEEAEAMMQIKFTYEQIELLPYLLSVMFLRIRDRRLIDTAFHIDEKSLSDTREYHITDILLEKTGPVPEQERLFITLQLLTTNIFSGEILTEKLTEDLEKVVLTCLDLFEKKALVSLKNKHILIEKLLLHLKPAYYRIKYQMNLEDTLYEKFNQEFEALNFIVKEAFDPLAKFIGREIPAGEIFFISLFIGSDMIPQNDIYHKQKRAIVLCPSGVTFSKIMENILVKLFPEIHFYPTISVREYAFFKAEVDIVFSSIPLKDGENVFVVQPFMNDIEKTQLRQHVLQNLFGMGNQLTSIDKIMEVVERNADIKDPNAIRDGIIDILSANIATDENKRVKKVYLHDLITEDNIMICEDVKNYQEAIRLASQPLLLQQAITANYVKTMIDNHKFHDPYIIIGEDIAIPHAMPNAGVNRLAMSLLVVKNGVYFSETEQVHFVIVIAPVDKEQHIEALYQIVHLAENHQILDDLLENVTKEKIMQTINQLVIREDE
>NZ_CP020828.1|WP_069007934.1|553024_553675_+|TalA-family-protein
MHLDSANLDDVKKIQASSIFKGITTNPTILVKEKCNRQTAINRILELTDKQVFVQTVGFTYEEILADARMLLTMFGKDKIAIKIPAHEAGTNVIDTLKKEDKTIQILGTAIYSADQAITAALAGADFVAPYVNRMSAANIDPFKEITQMRHFFDKKALKTQIMAASFKHSGQVMQAYESGADTVTIPYEIYSQMTNKVLGVEAIRVFNEDAVLYEK
>NZ_CP020828.1|WP_033920547.1|562847_563426_+|hypothetical-protein
MKKILVPILLLATILASCSSPNEKITKDTKISKTITIRADYKVPKDIKELEDDSANIVKVKFLQNKTIGKDGSTISEIEILTSYKGNLEKGSKVDISEPWYLSDGKYVAVENYIALDKEQEYTIFLGEKDKDTYPLSSLGYGKFGGSLKEDQAVLADFTILGEVQKFDFISENTEEVKNYQLIKEQVAGKYK
>NZ_CP020828.1|WP_003721297.1|563533_564214_+|type-1-glutamine-amidotransferase
MIIDVLQHVPHEGPGLIANWARENQHQLKIHSLFEENAHVPNDSDFLIVLGGPMGINDTAEFPWLKDERKLIKRLSEQHKPVFGVCLGAQQIAATFGSEITVNKEKEVGWFPVKRTSDKLLFFPESLNVFHWHQDTFALPTGSTRLFASEGCLNQAFLYGENIIGLQFHFEMEKAGIETILRIDEAFITPGKYVQSVEVMREKDVPEDNKQMLEAILDYLINPKTI
>NZ_CP020828.1|WP_003721298.1|564238_564598_-|hypothetical-protein
MEQILFIQTGFGVDVHGQNITKAAERAVRNAIFTNSMPGIQGLLPDGDLQNMVVNIKLALPCDADQLDEDTIRAIIPYGTVTIEKMAGGMMTTSGIFLEDKEDKNDLMYIVNASVETGY
>NZ_CP020828.1|WP_069007932.1|564604_565063_-|MarR-family-transcriptional-regulator
MNNEQNMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERELLTIEQGRRDKRQRCIFLTAAGKELENELGAAQRKQMSEIFTNSADTDGMHFTEVMKGYAKNRPGAAFIKDFKE
>NZ_CP020828.1|WP_033920546.1|565444_567280_+|lmo0514-family-class-1-internalin
MKKALKLFLATICMFIMIYPSTAAHAEETNIVNIPDANLKTYLNGLLKQASDAPITKTQMNTIQTVTLSGSTYTDLTGLEEAGNLVTLSINNTNIQTLEPIKNQTSLTYLTVGGDNVKDSLFVDLNGLVNLQSLSINGSEVTHNVFKTFNKLPKLTYLYAQNSMKITDISALASLPALTTLFLQFDGIDDFRPLNDFESFKNGNLKALAAFGQNTGRTNPRITLKSGKLDYNETNQTLYLPFSMMPKPLTSFDGTVAPFSKSTSASNTYLGFNDVALPSSRLSITDDGITVSGVTKEEFDNLDEIEYNARYDFPTGSYPTPPSMTSYTISSGTYDQYFDISHTLDLTADESFDYNQYDATSEEQFLKDVHAETDDGTAVKSDFDQVVKLDVPGEYTVTLNAENAAGLKATPVTVKVTVHEKPVITSDSQISYKKETTKSVDEFLKEIHGSVTGNAVLTSDFDKVVDLNTPGEYTVTLNAINDRGQKADPVTVVVTVTTSDSGHVNPVPPTPEVKPTPQEETDQTIIPEPQSETTEDSVKEDQAKDGQAKSEEKADKTSLTTKENKVEKSEKTNQPKTKALPQTGDTNKTALPIAGVMLSLAALLIFRKSKS
>NZ_CP020828.1|WP_003721301.1|567380_567812_+|universal-stress-protein
MEKYHRILVAVDGSEPAKLAFEKGLELALKLDGVLGIASIVDLRAFSPNVSYDGSLEEKAELELKTSVNEYAEKARTAGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NZ_CP020828.1|WP_069007931.1|567858_569289_-|CapA-family-protein
MKKLTYVIITGLVLVFIAGAFWITNSTNQSDQKATQTEPLKKTSPANVKTISSEAKKTLNSLASSGADKASISDLKQLIKELKSYPTEKNDSGVYLQNLTACLEAVKSYTTGKADEKALGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTVINAESAFTNATKAENKKWRIKSDPAHVAFLPASGVEAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNADAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDVKKYKKEDTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
>NZ_CP020828.1|WP_003721303.1|569409_570225_-|histidine-phosphatase-family-protein
MKKNIFKLLMALCAVLLIAGCGNSTSADKKETKETKEDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVKSAGKGLKDVDFSAAYSSDSGRAIQTANLILKESDKSADKEVQTDPRFREFNFGSYEGDLNENMWTDIAKSQGKTLEEWQKAGLSPKDFANSVAALDKTRVKEGENWPAEDYATIQARLKEGLTDVAKKESKNGDSNVLLVSHGLSIGALLDTIEPGYKLPAEGIKNASVTKITYKDGKFTIGDVNDLSYVEKGSK
>NZ_CP020828.1|WP_031644460.1|570577_571300_+|CRISPR-associated-endoribonuclease-Cas6
MRLKINCDFDSKIIPKDFQSKVVSLFKAGIMKSSPERYENLFGGNKHKQYTFSVYLPKPQNKGAEIQLNEANCIINFSTGDAETGIIFYNALISLRGSKVLFGAGNHITVKNIQIVPEKKIIGKQTILRTLSPVVSRDHNRETFKNWFYSFEDEEFEPTLKRNMLPYLMDAFGEQARYDLEKLKITPISMKKVVVYCHEIHIESSVGIFELEAEAYLQKYLVENGIGTMTGSGFGHLDFA
>NZ_CP020828.1|WP_049961575.1|571774_572500_+|CRISPR-associated-endoribonuclease-Cas6
MRLKILCHLSSEEFPLDYRRKIMMIIKKGMKREYPTIFADLYGQNTQKNFTFSVYFNHPTFEDDLIKVKDKTCIINFSTGEAELAIVFFNIFTLLKGENIKITENVDLKIHSVEVIPVRKIKNNIIKFKTLSPIVIRDHNQITQKDWFYTLEEDEAIMILKRNMIGKLAAKDYGESIEKEIKNIQIKPLKFKKTVVRFYKMQIATSLGEYEIKASPRLLNILIQNGIGTFTGNGFGMIEQL

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Crispr_ID: NZ_CP020828_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020828_4

578859-581087

Unclear

I-A

Consensus_repeat	Method
GTTTTAACTACTTATTATGAAATGTAAAT	PILER-CR
GTTTTAACTACTTATTATGAAATGTAAAT	CRISPRCasFinder
GTTTTAACTACTTATTATGAAATGTAAAT	CRT

34 spacers

cas2,cas3,cas5,cas7,cas8b2,cas6

The CRISPR arrays of NZ_CP020828_4

>merge|NZ_CP020828|4|578859-581087|PILER-CR,CRISPRCasFinder,CRT
GTTTTAACTACTTATTATGAAATGTAAATTCATTTAGAAATGAGTGGGAACGGTTTAGTGAAAAGTTTTAACTACTTATTATGAAATGTAAATTTCTTACTCTGTTTCAACATCTAAGGATAAAATCTCGTTTTAACTACTTATTATGAAATGTAAATTCCCCCTTAAGATACAAACTCGATTTGACAGGTGCAGGTTTTAACTACTTATTATGAAATGTAAATTCGTTTATGACCTTATGAAAGAGTTAACACCTCGACGTTTTAACTACTTATTATGAAATGTAAATCTTCCTACTTTTTGACATAAAAAATAAGCCGAGTTGGTTTTAACTACTTATTATGAAATGTAAATAAGTTCAAAACCTCCCACACCCGCTATGAATAAATTGTTTTAACTACTTATTATGAAATGTAAATGTCTTTGCATTTGATGATGATTACTTTTTTAAAGTCTGTTTTAACTACTTATTATGAAATGTAAATACGAGTATCAGCGCTAAAAGAGATTGTTAAGCGCCGTTTTAACTACTTATTATGAAATGTAAATTTAAGAACATAAGCTTCACTCTTTAAAGGGAGTAAAGTTTTAACTACTTATTATGAAATGTAAATAGTATCGCCTTCGCTAGGCGTTTCGGGCGGCGTTTCCGTTTTAACTACTTATTATGAAATGTAAATTGCCGCAAAAACGTTGGGGAACGTTGTTCAAGGTATTGTTTTAACTACTTATTATGAAATGTAAATACTTTAGAGAAAGAAAAACAAGAAAAAGTAAAACTGGTTTTAACTACTTATTATGAAATGTAAATTTCGTAATTTTACGATTATACTTTTTAGTCAAATTACGTTTTAACTACTTATTATGAAATGTAAATGTAACAAGTAGTGTTATACCTGCAACAATACCAGCGTTTTAACTACTTATTATGAAATGTAAATGTCCACATCGACAATAAAAAACACATTGTATCACTTGTTTTAACTACTTATTATGAAATGTAAATCTGGTTACTCAACTGGCGACAGTAATACACCTCAATGTTTTAACTACTTATTATGAAATGTAAATTTTGGATAGGTTGTTTCTGATAAATAGGTTCACGGTTTTAACTACTTATTATGAAATGTAAATAGAAAAAAAACATCTTTCCAATTTGTTGTTTTGCGTTTTAACTACTTATTATGAAATGTAAATACAAGTGCTAGAACAGAAGTTATAATTTGAACATTACGTTTTAACTACTTATTATGAAATGTAAATAGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTAGTTTTAACTACTTATTATGAAATGTAAATTTGTTCGACGGCTTAGACAACCATCACGCTTCTTTAGTTTTAACTACTTATTATGAAATGTAAATGCTTTTTTCAACAATTTTATCACCAGATGTCATTAGTTTTAACTACTTATTATGAAATGTAAATAAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGGGTTTTAACTACTTATTATGAAATGTAAATGTGTAATTCTTAATTCCGTATTGATTCGCTAGTTTTGTTTTAACTACTTATTATGAAATGTAAATTTAGAGATAACGTTAGCATCCGTGATAACTTAGTTGTTTTAACTACTTATTATGAAATGTAAATATAAATTATCCGTATGTTCTTGAATTGTTTCTTCGTTTTAACTACTTATTATGAAATGTAAATAAATTTTTTGTTGATAAGCATGCAGGAGCAAACAAGTTTTAACTACTTATTATGAAATGTAAATCAGTGATTATGCTAAGACCTACACAATCGTTATCACTGTTTTAACTACTTATTATGAAATGTAAATTAAGGTCATATAAGAAAAAATGTATTTTTTCCCGTTTTAACTACTTATTATGAAATCTAAATCAAGATATGCTAGAAATGGCGCAAATAGCGCGCGGTTTTAACTACTTATTATGAAATGTAAATGGCTTTCTGGAATTGTTTCGCTGACATCCCTGCCAGGTTTTAACTACTTATTATGAAATGTAAATCAAAACAGAGAACGCGTGTTCATTATCGGACATCTTAGTTTTAACTACTTATTATGAAATGTAAATTTTTGAAATATGAGGACTTAGAAAATGAAAAAAATGTTTTAACTACTTATTATGAAATGTAAATAAAAACTATGCAATTAGCAAAGTGATTTTATGTAATTGTTTTAACTACTTATTATGAAATCATAAA

>NZ_CP020828|4|2|578859-581021|PILER-CR
GTTTTAACTACTTATTATGAAATGTAAAT	TCATTTAGAAATGAGTGGGAACGGTTTAGTGAAAA
GTTTTAACTACTTATTATGAAATGTAAAT	TTCTTACTCTGTTTCAACATCTAAGGATAAAATCTC
GTTTTAACTACTTATTATGAAATGTAAAT	TCCCCCTTAAGATACAAACTCGATTTGACAGGTGCAG
GTTTTAACTACTTATTATGAAATGTAAAT	TCGTTTATGACCTTATGAAAGAGTTAACACCTCGAC
GTTTTAACTACTTATTATGAAATGTAAAT	CTTCCTACTTTTTGACATAAAAAATAAGCCGAGTTG
GTTTTAACTACTTATTATGAAATGTAAAT	AAGTTCAAAACCTCCCACACCCGCTATGAATAAATT
GTTTTAACTACTTATTATGAAATGTAAAT	GTCTTTGCATTTGATGATGATTACTTTTTTAAAGTCT
GTTTTAACTACTTATTATGAAATGTAAAT	ACGAGTATCAGCGCTAAAAGAGATTGTTAAGCGCC
GTTTTAACTACTTATTATGAAATGTAAAT	TTAAGAACATAAGCTTCACTCTTTAAAGGGAGTAAA
GTTTTAACTACTTATTATGAAATGTAAAT	AGTATCGCCTTCGCTAGGCGTTTCGGGCGGCGTTTCC
GTTTTAACTACTTATTATGAAATGTAAAT	TGCCGCAAAAACGTTGGGGAACGTTGTTCAAGGTATT
GTTTTAACTACTTATTATGAAATGTAAAT	ACTTTAGAGAAAGAAAAACAAGAAAAAGTAAAACTG
GTTTTAACTACTTATTATGAAATGTAAAT	TTCGTAATTTTACGATTATACTTTTTAGTCAAATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	GTAACAAGTAGTGTTATACCTGCAACAATACCAGC
GTTTTAACTACTTATTATGAAATGTAAAT	GTCCACATCGACAATAAAAAACACATTGTATCACTT
GTTTTAACTACTTATTATGAAATGTAAAT	CTGGTTACTCAACTGGCGACAGTAATACACCTCAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTGGATAGGTTGTTTCTGATAAATAGGTTCACG
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAAAAAAACATCTTTCCAATTTGTTGTTTTGC
GTTTTAACTACTTATTATGAAATGTAAAT	ACAAGTGCTAGAACAGAAGTTATAATTTGAACATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TTGTTCGACGGCTTAGACAACCATCACGCTTCTTTA
GTTTTAACTACTTATTATGAAATGTAAAT	GCTTTTTTCAACAATTTTATCACCAGATGTCATTA
GTTTTAACTACTTATTATGAAATGTAAAT	AAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGG
GTTTTAACTACTTATTATGAAATGTAAAT	GTGTAATTCTTAATTCCGTATTGATTCGCTAGTTTT
GTTTTAACTACTTATTATGAAATGTAAAT	TTAGAGATAACGTTAGCATCCGTGATAACTTAGTT
GTTTTAACTACTTATTATGAAATGTAAAT	ATAAATTATCCGTATGTTCTTGAATTGTTTCTTC
GTTTTAACTACTTATTATGAAATGTAAAT	AAATTTTTTGTTGATAAGCATGCAGGAGCAAACAA
GTTTTAACTACTTATTATGAAATGTAAAT	CAGTGATTATGCTAAGACCTACACAATCGTTATCACT
GTTTTAACTACTTATTATGAAATGTAAAT	TAAGGTCATATAAGAAAAAATGTATTTTTTCCC
GTTTTAACTACTTATTATGAAATCTAAAT	CAAGATATGCTAGAAATGGCGCAAATAGCGCGCG
GTTTTAACTACTTATTATGAAATGTAAAT	GGCTTTCTGGAATTGTTTCGCTGACATCCCTGCCAG
GTTTTAACTACTTATTATGAAATGTAAAT	CAAAACAGAGAACGCGTGTTCATTATCGGACATCTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTGAAATATGAGGACTTAGAAAATGAAAAAAAT
GTTTTAACTACTTATTATGAAATGTAAAT

>NZ_CP020828|4|3|578859-581087|CRISPRCasFinder
GTTTTAACTACTTATTATGAAATGTAAAT	TCATTTAGAAATGAGTGGGAACGGTTTAGTGAAAA
GTTTTAACTACTTATTATGAAATGTAAAT	TTCTTACTCTGTTTCAACATCTAAGGATAAAATCTC
GTTTTAACTACTTATTATGAAATGTAAAT	TCCCCCTTAAGATACAAACTCGATTTGACAGGTGCAG
GTTTTAACTACTTATTATGAAATGTAAAT	TCGTTTATGACCTTATGAAAGAGTTAACACCTCGAC
GTTTTAACTACTTATTATGAAATGTAAAT	CTTCCTACTTTTTGACATAAAAAATAAGCCGAGTTG
GTTTTAACTACTTATTATGAAATGTAAAT	AAGTTCAAAACCTCCCACACCCGCTATGAATAAATT
GTTTTAACTACTTATTATGAAATGTAAAT	GTCTTTGCATTTGATGATGATTACTTTTTTAAAGTCT
GTTTTAACTACTTATTATGAAATGTAAAT	ACGAGTATCAGCGCTAAAAGAGATTGTTAAGCGCC
GTTTTAACTACTTATTATGAAATGTAAAT	TTAAGAACATAAGCTTCACTCTTTAAAGGGAGTAAA
GTTTTAACTACTTATTATGAAATGTAAAT	AGTATCGCCTTCGCTAGGCGTTTCGGGCGGCGTTTCC
GTTTTAACTACTTATTATGAAATGTAAAT	TGCCGCAAAAACGTTGGGGAACGTTGTTCAAGGTATT
GTTTTAACTACTTATTATGAAATGTAAAT	ACTTTAGAGAAAGAAAAACAAGAAAAAGTAAAACTG
GTTTTAACTACTTATTATGAAATGTAAAT	TTCGTAATTTTACGATTATACTTTTTAGTCAAATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	GTAACAAGTAGTGTTATACCTGCAACAATACCAGC
GTTTTAACTACTTATTATGAAATGTAAAT	GTCCACATCGACAATAAAAAACACATTGTATCACTT
GTTTTAACTACTTATTATGAAATGTAAAT	CTGGTTACTCAACTGGCGACAGTAATACACCTCAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTGGATAGGTTGTTTCTGATAAATAGGTTCACG
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAAAAAAACATCTTTCCAATTTGTTGTTTTGC
GTTTTAACTACTTATTATGAAATGTAAAT	ACAAGTGCTAGAACAGAAGTTATAATTTGAACATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TTGTTCGACGGCTTAGACAACCATCACGCTTCTTTA
GTTTTAACTACTTATTATGAAATGTAAAT	GCTTTTTTCAACAATTTTATCACCAGATGTCATTA
GTTTTAACTACTTATTATGAAATGTAAAT	AAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGG
GTTTTAACTACTTATTATGAAATGTAAAT	GTGTAATTCTTAATTCCGTATTGATTCGCTAGTTTT
GTTTTAACTACTTATTATGAAATGTAAAT	TTAGAGATAACGTTAGCATCCGTGATAACTTAGTT
GTTTTAACTACTTATTATGAAATGTAAAT	ATAAATTATCCGTATGTTCTTGAATTGTTTCTTC
GTTTTAACTACTTATTATGAAATGTAAAT	AAATTTTTTGTTGATAAGCATGCAGGAGCAAACAA
GTTTTAACTACTTATTATGAAATGTAAAT	CAGTGATTATGCTAAGACCTACACAATCGTTATCACT
GTTTTAACTACTTATTATGAAATGTAAAT	TAAGGTCATATAAGAAAAAATGTATTTTTTCCC
GTTTTAACTACTTATTATGAAATCTAAAT	CAAGATATGCTAGAAATGGCGCAAATAGCGCGCG
GTTTTAACTACTTATTATGAAATGTAAAT	GGCTTTCTGGAATTGTTTCGCTGACATCCCTGCCAG
GTTTTAACTACTTATTATGAAATGTAAAT	CAAAACAGAGAACGCGTGTTCATTATCGGACATCTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTGAAATATGAGGACTTAGAAAATGAAAAAAAT
GTTTTAACTACTTATTATGAAATGTAAAT	AAAAACTATGCAATTAGCAAAGTGATTTTATGTAATT
GTTTTAACTACTTATTATGAAATCATAAA

>NZ_CP020828|4|3|578859-581087|CRT
GTTTTAACTACTTATTATGAAATGTAAAT	TCATTTAGAAATGAGTGGGAACGGTTTAGTGAAAA
GTTTTAACTACTTATTATGAAATGTAAAT	TTCTTACTCTGTTTCAACATCTAAGGATAAAATCTC
GTTTTAACTACTTATTATGAAATGTAAAT	TCCCCCTTAAGATACAAACTCGATTTGACAGGTGCAG
GTTTTAACTACTTATTATGAAATGTAAAT	TCGTTTATGACCTTATGAAAGAGTTAACACCTCGAC
GTTTTAACTACTTATTATGAAATGTAAAT	CTTCCTACTTTTTGACATAAAAAATAAGCCGAGTTG
GTTTTAACTACTTATTATGAAATGTAAAT	AAGTTCAAAACCTCCCACACCCGCTATGAATAAATT
GTTTTAACTACTTATTATGAAATGTAAAT	GTCTTTGCATTTGATGATGATTACTTTTTTAAAGTCT
GTTTTAACTACTTATTATGAAATGTAAAT	ACGAGTATCAGCGCTAAAAGAGATTGTTAAGCGCC
GTTTTAACTACTTATTATGAAATGTAAAT	TTAAGAACATAAGCTTCACTCTTTAAAGGGAGTAAA
GTTTTAACTACTTATTATGAAATGTAAAT	AGTATCGCCTTCGCTAGGCGTTTCGGGCGGCGTTTCC
GTTTTAACTACTTATTATGAAATGTAAAT	TGCCGCAAAAACGTTGGGGAACGTTGTTCAAGGTATT
GTTTTAACTACTTATTATGAAATGTAAAT	ACTTTAGAGAAAGAAAAACAAGAAAAAGTAAAACTG
GTTTTAACTACTTATTATGAAATGTAAAT	TTCGTAATTTTACGATTATACTTTTTAGTCAAATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	GTAACAAGTAGTGTTATACCTGCAACAATACCAGC
GTTTTAACTACTTATTATGAAATGTAAAT	GTCCACATCGACAATAAAAAACACATTGTATCACTT
GTTTTAACTACTTATTATGAAATGTAAAT	CTGGTTACTCAACTGGCGACAGTAATACACCTCAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTGGATAGGTTGTTTCTGATAAATAGGTTCACG
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAAAAAAACATCTTTCCAATTTGTTGTTTTGC
GTTTTAACTACTTATTATGAAATGTAAAT	ACAAGTGCTAGAACAGAAGTTATAATTTGAACATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TTGTTCGACGGCTTAGACAACCATCACGCTTCTTTA
GTTTTAACTACTTATTATGAAATGTAAAT	GCTTTTTTCAACAATTTTATCACCAGATGTCATTA
GTTTTAACTACTTATTATGAAATGTAAAT	AAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGG
GTTTTAACTACTTATTATGAAATGTAAAT	GTGTAATTCTTAATTCCGTATTGATTCGCTAGTTTT
GTTTTAACTACTTATTATGAAATGTAAAT	TTAGAGATAACGTTAGCATCCGTGATAACTTAGTT
GTTTTAACTACTTATTATGAAATGTAAAT	ATAAATTATCCGTATGTTCTTGAATTGTTTCTTC
GTTTTAACTACTTATTATGAAATGTAAAT	AAATTTTTTGTTGATAAGCATGCAGGAGCAAACAA
GTTTTAACTACTTATTATGAAATGTAAAT	CAGTGATTATGCTAAGACCTACACAATCGTTATCACT
GTTTTAACTACTTATTATGAAATGTAAAT	TAAGGTCATATAAGAAAAAATGTATTTTTTCCC
GTTTTAACTACTTATTATGAAATCTAAAT	CAAGATATGCTAGAAATGGCGCAAATAGCGCGCG
GTTTTAACTACTTATTATGAAATGTAAAT	GGCTTTCTGGAATTGTTTCGCTGACATCCCTGCCAG
GTTTTAACTACTTATTATGAAATGTAAAT	CAAAACAGAGAACGCGTGTTCATTATCGGACATCTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTGAAATATGAGGACTTAGAAAATGAAAAAAAT
GTTTTAACTACTTATTATGAAATGTAAAT	AAAAACTATGCAATTAGCAAAGTGATTTTATGTAATT
GTTTTAACTACTTATTATGAAATCATAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020828.1\|WP_069007930.1\|575896_578080_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP020828.1\|WP_026749766.1\|589039_590371_+\|DUF1254-domain-containing-protein	unknown	unknown	gnl\|CDD\|227659
NZ_CP020828.1\|WP_003721303.1\|569409_570225_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_CP020828.1\|WP_003721310.1\|578382_578661_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP020828.1\|WP_003721320.1\|590416_591157_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CP020828.1\|WP_031644460.1\|570577_571300_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CP020828.1\|WP_069007931.1\|567858_569289_-\|CapA-family-protein	unknown	unknown	gnl\|CDD\|225399
NZ_CP020828.1\|WP_003721307.1\|575046_575829_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|273860
NZ_CP020828.1\|WP_069007928.1\|592854_594351_+\|DUF2334-domain-containing-protein	unknown	unknown	gnl\|CDD\|227617
NZ_CP020828.1\|WP_031644454.1\|581673_583089_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP020828.1\|WP_045131588.1\|583220_584225_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_CP020828.1\|WP_003721321.1\|591386_592862_+\|membrane-protein	unknown	unknown	unknown
NZ_CP020828.1\|WP_031644458.1\|572515_574210_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	cas8b2	cd09754_cas8b2_CAS-I-B	gnl\|CDD\|187884
NZ_CP020828.1\|WP_069007929.1\|581158_581527_-\|DUF1304-domain-containing-protein	unknown	unknown	gnl\|CDD\|226282
NZ_CP020828.1\|WP_003721306.1\|574199_575069_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|274215
NZ_CP020828.1\|WP_049961575.1\|571774_572500_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|273848
NZ_CP020828.1\|WP_003726690.1\|585774_586527_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP020828.1\|WP_003726689.1\|584256_585573_-\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|133432
NZ_CP020828.1\|WP_009911276.1\|586633_587077_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020828.1\|WP_003721301.1\|567380_567812_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180

Protein	Function_ID	Function_description	E-value
NZ_CP020828.1\|WP_069007930.1\|575896_578080_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	6.89223e-59
NZ_CP020828.1\|WP_026749766.1\|589039_590371_+\|DUF1254-domain-containing-protein	gnl\|CDD\|227659	COG5361, COG5361, Uncharacterized conserved protein [Function unknown].	5.15204e-73
NZ_CP020828.1\|WP_003721303.1\|569409_570225_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.01016e-50
NZ_CP020828.1\|WP_003721310.1\|578382_578661_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.1393e-30
NZ_CP020828.1\|WP_003721320.1\|590416_591157_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	2.56491e-51
NZ_CP020828.1\|WP_031644460.1\|570577_571300_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.57817e-31
NZ_CP020828.1\|WP_069007931.1\|567858_569289_-\|CapA-family-protein	gnl\|CDD\|225399	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane].	2.2626e-101
NZ_CP020828.1\|WP_003721307.1\|575046_575829_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|273860	TIGR01895, conserved_hypothetical_protein, CRISPR-associated protein Cas5, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family is represented by TM1800 from Thermotoga maritima. It is related to TIGR01868 (CRISPR-associated protein, CT1976 family).	1.37797e-23
NZ_CP020828.1\|WP_069007928.1\|592854_594351_+\|DUF2334-domain-containing-protein	gnl\|CDD\|227617	COG5298, COG5298, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP020828.1\|WP_031644454.1\|581673_583089_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.42897e-80
NZ_CP020828.1\|WP_045131588.1\|583220_584225_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.15304e-20
NZ_CP020828.1\|WP_031644458.1\|572515_574210_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	gnl\|CDD\|187884	cd09754, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	1.65879e-25
NZ_CP020828.1\|WP_069007929.1\|581158_581527_-\|DUF1304-domain-containing-protein	gnl\|CDD\|226282	COG3759, COG3759, Predicted membrane protein [Function unknown].	1.01266e-40
NZ_CP020828.1\|WP_003721306.1\|574199_575069_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	1.33672e-55
NZ_CP020828.1\|WP_049961575.1\|571774_572500_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.25366e-25
NZ_CP020828.1\|WP_003726690.1\|585774_586527_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	7.01666e-64
NZ_CP020828.1\|WP_003726689.1\|584256_585573_-\|6-phospho-beta-glucosidase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CP020828.1\|WP_003721301.1\|567380_567812_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.03126e-27

>NZ_CP020828.1|WP_003721310.1|578382_578661_+|CRISPR-associated-endonuclease-Cas2
MYVILIYDISIENGGAKVWRNVFKICKKYLTHVQKSVFEGEITPALLVKLRMELDKYIRDDQDSVIVFSSRQQRWLEKEFWGLTDEKTSNFF
>NZ_CP020828.1|WP_069007930.1|575896_578080_+|CRISPR-associated-helicase/endonuclease-Cas3
MHKYLAKSNPEETIQEHTDNLLKNYQRLKKLYPAVEIDWYLLELVCLLHDLGKMNLLFQTKLGNASGKGKEIPHGYLSVAFVPDSKLEEMGYSEDEIKVVYQAIARHHERKYDFSDSEWKKEIIKLEEQWAGFIYSQLGGNAEYSSEVEMLYFYPGSRIFEGNSAADAETFKKYVLLKGLLNRIDFAASGGIDVELENDFLMDSMEVQLSHFKAENPEADWNALQKYMMQHQNENIVVIAETGMGKTEAGLLWLGNNKGFFTLPLRAAINAIYERITKNIVTTNQAERVGLLHSETYSQYLLHEGNAEMDIDEYYTRTRQMSLPITICTLDQLFDFVFRYAGFEHKLATLSYSKVIIDEIQMYSSDLLAYLILGLSYIDKFGGKFCIMTATLPGIVTDLLLENGVDFVQPEDKFVSSRIRHSMEMVHTEIESEFIKPFFNNNRILVICNTISKAKKIYSELKEHFQGEEIHLIHSQFIKKDRSAKEDAIFKDGQKDSTKKCIWVATQVVEASLDIDFDLLFTELSDVNGLFQRMGRCYRNRALDVDTNVYVFDGGAKVCSGIGTFIDKLIFVNSKTILNEHAGVLKEEKKMELVEQVYSTEALSGSEFYNDLIDKLNYVKAFESYLMNKADVRMRFRNINSVSVIPEEVWQDNAEEINSYFVTLRKTSKEISTKEKMIARTNLAEFMVSIPDYLYKKGESVVREINRYESVIEFKCGYSSDVGVFMR
>NZ_CP020828.1|WP_003721307.1|575046_575829_+|type-I-B-CRISPR-associated-protein-Cas5
MLIMKAIRVRLWQDLVNFKKPTSFQLKETYPLPPYSTVIGMVHTLCGFTSYHEMKISIQGKYFSKVNDLATRYEFKNGMTYDASRHQIKVDKYGVSRGVSTVELLVDLELLLHIIPEDPSLVPIIEKAFREPIEFPSLGRREDIATIQKVEVVDVEKRQPKKSTEISDGYNAYVPISLTENNSVHFKSHESSVGRDKLLGTRYLLTEKYERVNHGTEKAPKFFRKWRKKDVIYSSRIFVSKKDVFFFDEDDYLVFIEEEE
>NZ_CP020828.1|WP_003721306.1|574199_575069_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MKNKGLAMTIIFQAESANYGESLGNISSLKKISRNNGDQYTYISRQAIRYNLMDQIGEKEAPVKAEGGGDKKVIQFLSEATITDFPELDFFGYLKTEKGSGGQKRSAKVRLSNAISLETFKGDLDFLTNKGQADKLNENMNIAQAEIHKSYYRYTITIDLDQIGIDGEIALDNKEKARRVKKLMDTVAFLYRDIRGRREDLKPLFVIGGVYDVKNPVFQNIVDVADNNIVIKNIKDLLTYEDIKENTRVGIIDGQFANSDEVKVELKAESVPAFFNDIKGKIDAYYESN
>NZ_CP020828.1|WP_031644458.1|572515_574210_+|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1
MQTEIEVRSNDWLINAGLVGFLNIVGKDNVKIDGQSIYFTADLLEDFETKYFNFFIQEYKETLAWSKIVSYKEAMERFRADGFASFDEDALNNLNKYVKNVVKFYLKKANYIKVFPLINSDANVNKWLENLNTINLTKKQKWEEVKPDIVEKVEQIYTQLDVIIDFCTSEKGLRYLGAKNLIYSVINKGWSGVSFLFKQTKFIDPYLDYKTTFVDPVIEHLDTDLSKAKYNCFNCNQPIKNLKLDLSFMNEVGFDTARKTSHVWDFNNDVATCPICRLVYSCVPAGFTYVYGEGMFVNDSYGVNELHHVNERMRKSILRFNKDGINSTNTYQALVESITSEHENNRRYELADIQLIRYENEHYHFNLLSKKMLHIMNDSKEILKSLIRCGYNEGNLNINLYKEVIQHLMNNENLFTLIHKLIFYKQSSVNGLYYNMWNVSGVLEINTKFLKEIEVMTNIEERDLTNAQKSGGDFKQAYVDKNSENKVSSITYKLLNALKLNDKNGFMDILLNSYSYLGKPVPTVFMSSFSSKETFKSIGYAFMIGVSANKTKSKNKDGGNTDEK
>NZ_CP020828.1|WP_049961575.1|571774_572500_+|CRISPR-associated-endoribonuclease-Cas6
MRLKILCHLSSEEFPLDYRRKIMMIIKKGMKREYPTIFADLYGQNTQKNFTFSVYFNHPTFEDDLIKVKDKTCIINFSTGEAELAIVFFNIFTLLKGENIKITENVDLKIHSVEVIPVRKIKNNIIKFKTLSPIVIRDHNQITQKDWFYTLEEDEAIMILKRNMIGKLAAKDYGESIEKEIKNIQIKPLKFKKTVVRFYKMQIATSLGEYEIKASPRLLNILIQNGIGTFTGNGFGMIEQL
>NZ_CP020828.1|WP_031644460.1|570577_571300_+|CRISPR-associated-endoribonuclease-Cas6
MRLKINCDFDSKIIPKDFQSKVVSLFKAGIMKSSPERYENLFGGNKHKQYTFSVYLPKPQNKGAEIQLNEANCIINFSTGDAETGIIFYNALISLRGSKVLFGAGNHITVKNIQIVPEKKIIGKQTILRTLSPVVSRDHNRETFKNWFYSFEDEEFEPTLKRNMLPYLMDAFGEQARYDLEKLKITPISMKKVVVYCHEIHIESSVGIFELEAEAYLQKYLVENGIGTMTGSGFGHLDFA
>NZ_CP020828.1|WP_003721303.1|569409_570225_-|histidine-phosphatase-family-protein
MKKNIFKLLMALCAVLLIAGCGNSTSADKKETKETKEDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVKSAGKGLKDVDFSAAYSSDSGRAIQTANLILKESDKSADKEVQTDPRFREFNFGSYEGDLNENMWTDIAKSQGKTLEEWQKAGLSPKDFANSVAALDKTRVKEGENWPAEDYATIQARLKEGLTDVAKKESKNGDSNVLLVSHGLSIGALLDTIEPGYKLPAEGIKNASVTKITYKDGKFTIGDVNDLSYVEKGSK
>NZ_CP020828.1|WP_069007931.1|567858_569289_-|CapA-family-protein
MKKLTYVIITGLVLVFIAGAFWITNSTNQSDQKATQTEPLKKTSPANVKTISSEAKKTLNSLASSGADKASISDLKQLIKELKSYPTEKNDSGVYLQNLTACLEAVKSYTTGKADEKALGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTVINAESAFTNATKAENKKWRIKSDPAHVAFLPASGVEAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNADAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDVKKYKKEDTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
>NZ_CP020828.1|WP_003721301.1|567380_567812_+|universal-stress-protein
MEKYHRILVAVDGSEPAKLAFEKGLELALKLDGVLGIASIVDLRAFSPNVSYDGSLEEKAELELKTSVNEYAEKARTAGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NZ_CP020828.1|WP_069007929.1|581158_581527_-|DUF1304-domain-containing-protein
MAILAFILTFIVMIEHIYIMILEMFFANTKLAAKTFGVEKELLANKKVQTLFANQGLYNGFLAAGLAWGLFFAGAGFAETVQIFFLSCVVVAALFGGATSSKGILVKQGLPAVLALVAVLLV
>NZ_CP020828.1|WP_031644454.1|581673_583089_+|multidrug-efflux-MFS-transporter
MQQEATGGQKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAALSPTFAMLMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGMKFMQNVSVVTKPKIDILSIILSTLGFGGVVFAFSSAGESGWGSATVLVSIIVGGLALGLFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVVALFFLTRIEVGTSALTIIVLHSVLMIGISMVMMPAQTNGLNQLPPKLYPDGTAIMNTLQQVSGAIGTAVAITIMSAGQKAYMETAQGMGPEQMVASLTAGIQNAFVFGLIMACIGLLCSLFIRKAK
>NZ_CP020828.1|WP_045131588.1|583220_584225_+|ROK-family-transcriptional-regulator
MAIPRDLKELNKKNIKSILRQQGAMTKAEIAEVTGLSVVTVNKLIRDLVENEEILEQDNSVATGGRRAVSYEINPNFQQVLVISLQEKWKKITYSFSVYNLLGEPEFVEDMSGEDLDITALKRNTKDIICAFPKISCVVIGVPGIEIGGKLRAMDFPLLLNVQLRETLEAEVNLPVLVETDTNAAILGYKNRPVKEENIVGLYYPERFPPGAGLLMNGEILKGQNGLAGEIKHMPLQVDWDNFDFSVDEIKAHIRKMALLTMSFYDPETIVLYTNFYFGQKDFMEELKEELKQVYPYAVLPEIVLSRKFTTDYRIGLLAFGIDYLENNMTDWRI
>NZ_CP020828.1|WP_003726689.1|584256_585573_-|6-phospho-beta-glucosidase
MTKGIKIATIGGGSSYTPELIEGFIKRQDELPVRELWLVDVEAGREKLEIVGNLAKRMVEKAGVDMEVHLTLDREEALKDADFVTTQLRVGLLDARVKDERIPNSYGVVGQETNGPGGMFKGLRTIPVILDICKDMERLCPDAWLINFANPAGMVTEAVLRYSNQKKVVGLCNGPIGIERNIAETLGVDVSEIYVEFVGLNHMVFAKTVYHNGKDVTKDVVFKMTEDEAGSSLKNINATGWDKTFLRTLNMIPIDYLRYYWQTKQQLEDQARAYAEHGTRAEVVKKVEAELFELYKQEELAEKPKQLEQRGGAYYSEAACNLINSIYNDKRDIQIVNTRNNGAILDIDPDSAVETNCVITRQGPIPLASGRLPIAINGIIQEIKTFERLTAEAAVTGDYDKALLAMTINPLTPSESVAREMLDELLEAHKEYLPNFFK
>NZ_CP020828.1|WP_003726690.1|585774_586527_+|MurR/RpiR-family-transcriptional-regulator
MLFLDKNLELNDTELDIYNYIVANLDKVVYMRIRDLATEAHVSTTTILRFCRKFGCNGFSEFRVKLQLYLEEQKLAQIDMADETTYIDFLKRTAQPEFKAQIQNAVEILRDRELVLFAGVGSSGVIAEYGAIYFSSLFTLALHIEDPLNHPFYHLSSKLSDKICMIAISVEGENEDIIRYIHQLKAQNCKVISITNSAKSTIARLSDANIAYYINKEMYQEANITSQLPALYTIENIAREIRTQIDKEKM
>NZ_CP020828.1|WP_009911276.1|586633_587077_+|hypothetical-protein
MYSNMKEKVVFTLIMCSLMILCMSSYNIFLENGIGTDSLMIILKAFVPFLFIGFLLDFFVVGKIANRLHALLVSEDASKFKKIIMMQLLMVTFMCVLMSTLSLIVNQGEWSHLGILILRNYFVALFLQIFIVSPFVRLISPRIFALL
>NZ_CP020828.1|WP_026749766.1|589039_590371_+|DUF1254-domain-containing-protein
MATQKNLVDLATKAYIYGFPFIFNTQQIERYVTVGIGGTKQVPFNNFTHASRLAEPSDKFVSVNNDTIYSNAPIDVSAGPVVLSVPDTSGRYYVLQFVDAWSNNFAYVGKRATGTSAGKFLLTPPNWNGDVPADMIEIKFPTNIGIIIGRLACDGEADLPTVRELQEQLKITPLNEGKEVDGFPEYDRSLGKELAFFEQLRVYMAQFPPAERDLVKQESFAPIGLMEKGVSPYSNPSEELKNALIEGAKAGLANIKKATTNFKSENGWGLTQHLFDYNADFFEIGTKKSLDWVIEDREEAYIIRAVSAITALWGNHGYEAVYLMTWTDTDGNALNGKNKYTLELNPIPPVDSFWSITMYDLPEYFLCENPINRYSIGDRTPGIQYNDDGGIAIVVSKDEPTDPKERANWLPAPDAEFRPMFRLYNPQQPLVDGSYHFPGFEKK
>NZ_CP020828.1|WP_003721320.1|590416_591157_-|MerR-family-transcriptional-regulator
MQIKELAELTGVSVRTLHHYDKIGLLVPQKDDWNGYRIYSEKDVDKLQQILFFKELDFPLKKIQQILDDPLFDKNVALDMQRHLLIEKKQRIETMLATLDLTIKNEKGEITMTNKEKFTGFDFSSNPYEEEARKLWGDKVVEKANEKVNNMSEKEQLTLKESFDAEFRHLASVRKLTPESEEAQLEIDHFFHYLNDTHGNIYSLEAFASLGEMYVNDERFTKNIDQFGDGLSQFLQEAMTIYAKNK
>NZ_CP020828.1|WP_003721321.1|591386_592862_+|membrane-protein
MIRKVKSISMWLWHHLTPQIFAVICVFIITIIALFMPPYIGMADNGDFFRIFSSNGLFVNNTNYDALQFGHFVKEFGIYQYFNENQVAIYSSQSIFIQMALLLNKLFWSTTVFDVRFLGGLQLALLLPAIYLLVAGLTAKMKGWPGYVVAALTVFIFADTAYTAYFNSFFSEGLILIMMLYISAGFLLLYQHKYNDYAMLGLIFVASLILITAKQQNAPIAVVIAVCGILVFFIRKNRAFRISAAATFLVIFLSGVVMYAFIPGEFVTINQYQTMTRGVLLDSENPEKSLEEMGMNSEFALLKGTNFYQKYKMIDLDSKLMEKEFYPNYNFVTVLSYYLENPKQFGKMLDLSAQNSFSIRPFEMGNFEKATGYKFKEKTHFFSAYSDVKEKFAPAKFTFLILWALVFLICYGVSAFKHFREKNIRGTLLFDLIVLLIGSGFAVILVTIVGDGEADLTKHNFLFNVCFDLTMLIGAASLLEVYLKKRGERNA
>NZ_CP020828.1|WP_069007928.1|592854_594351_+|DUF2334-domain-containing-protein
MRKKMIISILLAFVIFIVGGHSAIAKTDDGVVVFYDSLATGTENEGNMDALLRMLNSLGKRVTIYSWEENPDLSQTSEIIVLQNKNDGLANDWTKKLAKSKAKIAYIGGNPPTFLTDKLQLKTKAITDASITIQTEAGLSGKPQLVNETNLITSYKGTSFGEMDAAENGQAAYGVQAGNYAYAPLFQTDNTSEFTLMDVLKALFDIKTTTNQYAFITGVNPFVDFDLLKKTADTFYEKGIPFIVSAGPVFYNQDFQAAKNYAEILRYVQAKNGTIMMNVPAVTYGDSPAGELESIMQKSVNFFAENDIAPIGVTAELYWNFDKVYGVEGFAPFNTGILLPNQKIIHTTKVNNGSAFEKSPYSVANDFYATTTEGRNFPVDIAITYSFFDNEKELKAAAEELANDNISDFRFQNHGVKTNKDTIESSAGSLYINNQPVALDGDLNYIKTKNKAVKQTGSLEGFFGYQNTFFTIVIVLSLGIIGVLFVFGYRLYMKKYMK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP020828_4	4.26\|580509\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580509-580542	34	NZ_CP020828.1	575927-575960	0	1.0
NZ_CP020828_2	2.6\|523975\|39\|NZ_CP020828\|CRT	523975-524013	39	NZ_CP020828.1	521770-521808	1	0.974

1. spacer 4.26|580509|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to position: 575927-575960, mismatch: 0, identity: 1.0

ataaattatccgtatgttcttgaattgtttcttc	CRISPR spacer
ataaattatccgtatgttcttgaattgtttcttc	Protospacer
**********************************

2. spacer 2.6|523975|39|NZ_CP020828|CRT matches to position: 521770-521808, mismatch: 1, identity: 0.974

cgtgccatgtttgctggttgtactagtcttgaagcgtta	CRISPR spacer
cgtgccatgtttgctggctgtactagtcttgaagcgtta	Protospacer
*****************.*********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP020828_3	3.1\|562001\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562001-562035	35	KJ094023	Listeria phage LP-101, complete genome	6873-6907	0	1.0
NZ_CP020828_3	3.2\|562065\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562065-562098	34	NZ_CP011399	Listeria monocytogenes strain CFSAN008100 plasmid pCFSAN008100, complete sequence	60292-60325	0	1.0
NZ_CP020828_3	3.2\|562065\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562065-562098	34	KJ094023	Listeria phage LP-101, complete genome	27168-27201	0	1.0
NZ_CP020828_3	3.4\|562195\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562195-562229	35	NC_003216	Listeria phage A118, complete genome	34139-34173	0	1.0
NZ_CP020828_3	3.4\|562195\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562195-562229	35	AJ242593	Bacteriophage A118 complete genome	34139-34173	0	1.0
NZ_CP020828_3	3.4\|562195\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562195-562229	35	MH341452	Listeria phage PSU-VKH-LP040, complete genome	32598-32632	0	1.0
NZ_CP020828_3	3.4\|562195\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562195-562229	35	DQ003642	Listeria phage A006, complete genome	31434-31468	0	1.0
NZ_CP020828_4	4.6\|579213\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579213-579248	36	KJ094023	Listeria phage LP-101, complete genome	18341-18376	0	1.0
NZ_CP020828_4	4.16\|579865\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579865-579900	36	NC_003216	Listeria phage A118, complete genome	18563-18598	0	1.0
NZ_CP020828_4	4.16\|579865\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579865-579900	36	AJ242593	Bacteriophage A118 complete genome	18563-18598	0	1.0
NZ_CP020828_4	4.20\|580122\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580122-580155	34	NC_003216	Listeria phage A118, complete genome	19172-19205	0	1.0
NZ_CP020828_4	4.20\|580122\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580122-580155	34	AJ242593	Bacteriophage A118 complete genome	19172-19205	0	1.0
NZ_CP020828_3	3.1\|562001\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562001-562035	35	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	216400-216434	1	0.971
NZ_CP020828_3	3.3\|562128\|38\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562128-562165	38	MH341451	Listeria phage PSU-VKH-LP019, complete genome	10625-10662	1	0.974
NZ_CP020828_4	4.5\|579148\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579148-579183	36	KJ094023	Listeria phage LP-101, complete genome	17910-17945	1	0.972
NZ_CP020828_4	4.8\|579344\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579344-579378	35	MH341452	Listeria phage PSU-VKH-LP040, complete genome	377-411	1	0.971
NZ_CP020828_4	4.8\|579344\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579344-579378	35	KP399678	Listeria phage vB_LmoS_293, complete genome	330-364	1	0.971
NZ_CP020828_4	4.27\|580572\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580572-580606	35	NC_009813	Listeria phage B054, complete genome	21546-21580	1	0.971
NZ_CP020828_4	4.32\|580892\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580892-580928	37	KY705255	Streptococcus phage P0095, complete genome	33666-33702	1	0.973
NZ_CP020828_4	4.32\|580892\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580892-580928	37	KY705251	Streptococcus phage P0091, complete genome	32778-32814	1	0.973
NZ_CP020828_4	4.32\|580892\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580892-580928	37	KX879643	Streptococcus phage CHPC1151, complete genome	31697-31733	1	0.973
NZ_CP020828_4	4.32\|580892\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580892-580928	37	MK202161	Streptococcus phage CHPC1282, complete genome	32484-32520	1	0.973
NZ_CP020828_4	4.32\|580892\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580892-580928	37	KY705252	Streptococcus phage P0092, complete genome	31845-31881	1	0.973
NZ_CP020828_4	4.32\|580892\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580892-580928	37	MH937506	Streptococcus phage CHPC1148, complete genome	35552-35588	1	0.973
NZ_CP020828_4	4.32\|580892\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580892-580928	37	KY705253	Streptococcus phage P0093, complete genome	32631-32667	1	0.973
NZ_CP020828_4	4.32\|580892\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580892-580928	37	KY705254	Streptococcus phage P0094, complete genome	31034-31070	1	0.973
NZ_CP020828_3	3.2\|562065\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562065-562098	34	NC_021539	Listeria phage LP-030-2, complete genome	23033-23066	2	0.941
NZ_CP020828_3	3.2\|562065\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562065-562098	34	AJ312240	Bacteriophage PSA complete genome	22756-22789	2	0.941
NZ_CP020828_3	3.3\|562128\|38\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562128-562165	38	DQ003642	Listeria phage A006, complete genome	10641-10678	2	0.947
NZ_CP020828_4	4.15\|579800\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579800-579835	36	MH341453	Listeria phage PSU-VKH-LP041, complete genome	26132-26167	2	0.944
NZ_CP020828_4	4.21\|580185\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580185-580220	36	KJ094022	Listeria phage LP-030-3, complete genome	38302-38337	2	0.944
NZ_CP020828_4	4.28\|580636\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580636-580672	37	KJ094023	Listeria phage LP-101, complete genome	37501-37537	2	0.946
NZ_CP020828_4	4.32\|580892\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580892-580928	37	MN689509	Lactococcus phage CHPC1175, complete genome	29544-29580	2	0.946
NZ_CP020828_4	4.32\|580892\|37\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580892-580928	37	MK448735	Streptococcus phage Javan349, complete genome	11483-11519	2	0.946
NZ_CP020828_4	4.8\|579344\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579344-579378	35	DQ003637	Listeria phage A500, complete genome	334-368	3	0.914
NZ_CP020828_4	4.8\|579344\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579344-579378	35	KJ094022	Listeria phage LP-030-3, complete genome	8756-8790	3	0.914
NZ_CP020828_3	3.4\|562195\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562195-562229	35	KP399677	Listeria phage vB_LmoS_188, complete genome	31932-31966	4	0.886
NZ_CP020828_3	3.4\|562195\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	562195-562229	35	KP399678	Listeria phage vB_LmoS_293, complete genome	33169-33203	4	0.886
NZ_CP020828_4	4.5\|579148\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579148-579183	36	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	227438-227473	4	0.889
NZ_CP020828_4	4.24\|580380\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580380-580415	36	FW590615	JP 2010534058-A/25: ANTIBIOTIC RESISTANCE FREE LISTERIA STRAINS AND METHODS FOR CONSTRUCTING AND USING SAME	3844-3879	4	0.889
NZ_CP020828_4	4.24\|580380\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580380-580415	36	HI504184	Sequence 26 from Patent EP2147092	3844-3879	4	0.889
NZ_CP020828_4	4.24\|580380\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580380-580415	36	AJ417489	bacteriophage U153 int gene for U153 integrase	3844-3879	4	0.889
NZ_CP020828_4	4.18\|579993\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579993-580026	34	NC_022111	Prevotella sp. oral taxon 299 str. F0039 plasmid, complete sequence	1764851-1764884	6	0.824
NZ_CP020828_4	4.33\|580958\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580958-580992	35	MN694189	Marine virus AFVG_250M578, complete genome	47879-47913	6	0.829
NZ_CP020828_4	4.12\|579605\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579605-579640	36	AP013647	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C72-MedDCM-OCT-S41-C96, * SEQUENCING IN PROGRESS *	13305-13340	8	0.778
NZ_CP020828_4	4.24\|580380\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580380-580415	36	NC_019743	Microcoleus sp. PCC 7113 plasmid pMIC7113.08, complete sequence	4997-5032	8	0.778
NZ_CP020828_4	4.26\|580509\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580509-580542	34	KT070867	Bacillus phage PBC2, complete genome	75389-75422	8	0.765
NZ_CP020828_4	4.18\|579993\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579993-580026	34	NZ_CP038863	Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence	39302-39335	9	0.735
NZ_CP020828_4	4.22\|580250\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580250-580284	35	NC_014533	Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence	491525-491559	9	0.743
NZ_CP020828_4	4.33\|580958\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580958-580992	35	MK448625	Streptococcus satellite phage Javan738, complete genome	5960-5994	9	0.743
NZ_CP020828_4	4.33\|580958\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580958-580992	35	MK448449	Streptococcus satellite phage Javan356, complete genome	4490-4524	9	0.743
NZ_CP020828_4	4.33\|580958\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580958-580992	35	MK448636	Streptococcus satellite phage Javan749, complete genome	6112-6146	9	0.743
NZ_CP020828_4	4.33\|580958\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580958-580992	35	NZ_CP045037	Lactobacillus mali strain LM596 plasmid unnamed2, complete sequence	34734-34768	9	0.743
NZ_CP020828_4	4.33\|580958\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580958-580992	35	NZ_CP018177	Lactobacillus hordei strain TMW 1.1822 plasmid pL11822-1, complete sequence	11325-11359	9	0.743
NZ_CP020828_4	4.33\|580958\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580958-580992	35	NZ_CP018181	Lactobacillus nagelii strain TMW 1.1827 plasmid pL11827-1, complete sequence	63608-63642	9	0.743
NZ_CP020828_4	4.12\|579605\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579605-579640	36	NZ_AP015030	Pseudomonas putida strain KF715 plasmid pKF715A, complete sequence	410342-410377	11	0.694
NZ_CP020828_4	4.12\|579605\|36\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	579605-579640	36	NZ_CP018048	Pseudomonas aeruginosa strain DN1 plasmid unnamed1, complete sequence	142304-142339	11	0.694
NZ_CP020828_4	4.25\|580445\|35\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580445-580479	35	AP014250	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S40-C9, * SEQUENCING IN PROGRESS *	20129-20163	11	0.686
NZ_CP020828_4	4.30\|580764\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580764-580797	34	NZ_CP034816	Paracoccus sp. Arc7-R13 plasmid unnamed6, complete sequence	26153-26186	11	0.676
NZ_CP020828_4	4.26\|580509\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580509-580542	34	NC_031922	Synechococcus phage S-CAM9 isolate 1109NB16, complete genome	146996-147029	12	0.647
NZ_CP020828_4	4.26\|580509\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580509-580542	34	KU686204	Synechococcus phage S-CAM9 isolate 0808SB05, complete genome	146978-147011	12	0.647
NZ_CP020828_4	4.26\|580509\|34\|NZ_CP020828\|PILER-CR,CRISPRCasFinder,CRT	580509-580542	34	KU686205	Synechococcus phage S-CAM9 isolate 0908SB82, complete genome	146825-146858	12	0.647

1. spacer 3.1|562001|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 0, identity: 1.0

ttggatgcaaaaactttaatagcctctgcatcaag	CRISPR spacer
ttggatgcaaaaactttaatagcctctgcatcaag	Protospacer
***********************************

2. spacer 3.2|562065|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011399 (Listeria monocytogenes strain CFSAN008100 plasmid pCFSAN008100, complete sequence) position: , mismatch: 0, identity: 1.0

aaatcaacgggtaaatatttactcacagagcttc	CRISPR spacer
aaatcaacgggtaaatatttactcacagagcttc	Protospacer
**********************************

3. spacer 3.2|562065|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 0, identity: 1.0

aaatcaacgggtaaatatttactcacagagcttc	CRISPR spacer
aaatcaacgggtaaatatttactcacagagcttc	Protospacer
**********************************

4. spacer 3.4|562195|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NC_003216 (Listeria phage A118, complete genome) position: , mismatch: 0, identity: 1.0

gttgaactagaaaaactgcttgcttgggtagatga	CRISPR spacer
gttgaactagaaaaactgcttgcttgggtagatga	Protospacer
***********************************

5. spacer 3.4|562195|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to AJ242593 (Bacteriophage A118 complete genome) position: , mismatch: 0, identity: 1.0

gttgaactagaaaaactgcttgcttgggtagatga	CRISPR spacer
gttgaactagaaaaactgcttgcttgggtagatga	Protospacer
***********************************

6. spacer 3.4|562195|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MH341452 (Listeria phage PSU-VKH-LP040, complete genome) position: , mismatch: 0, identity: 1.0

gttgaactagaaaaactgcttgcttgggtagatga	CRISPR spacer
gttgaactagaaaaactgcttgcttgggtagatga	Protospacer
***********************************

7. spacer 3.4|562195|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to DQ003642 (Listeria phage A006, complete genome) position: , mismatch: 0, identity: 1.0

gttgaactagaaaaactgcttgcttgggtagatga	CRISPR spacer
gttgaactagaaaaactgcttgcttgggtagatga	Protospacer
***********************************

8. spacer 4.6|579213|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 0, identity: 1.0

aagttcaaaacctcccacacccgctatgaataaatt	CRISPR spacer
aagttcaaaacctcccacacccgctatgaataaatt	Protospacer
************************************

9. spacer 4.16|579865|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NC_003216 (Listeria phage A118, complete genome) position: , mismatch: 0, identity: 1.0

ctggttactcaactggcgacagtaatacacctcaat	CRISPR spacer
ctggttactcaactggcgacagtaatacacctcaat	Protospacer
************************************

10. spacer 4.16|579865|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to AJ242593 (Bacteriophage A118 complete genome) position: , mismatch: 0, identity: 1.0

ctggttactcaactggcgacagtaatacacctcaat	CRISPR spacer
ctggttactcaactggcgacagtaatacacctcaat	Protospacer
************************************

11. spacer 4.20|580122|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NC_003216 (Listeria phage A118, complete genome) position: , mismatch: 0, identity: 1.0

agaagcgttagcggcattgttcgaaagtaattta	CRISPR spacer
agaagcgttagcggcattgttcgaaagtaattta	Protospacer
**********************************

12. spacer 4.20|580122|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to AJ242593 (Bacteriophage A118 complete genome) position: , mismatch: 0, identity: 1.0

agaagcgttagcggcattgttcgaaagtaattta	CRISPR spacer
agaagcgttagcggcattgttcgaaagtaattta	Protospacer
**********************************

13. spacer 3.1|562001|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 1, identity: 0.971

ttggatgcaaaaactttaatagcctctgcatcaag	CRISPR spacer
ttggatgcaaaaactttaatagcttctgcatcaag	Protospacer
***********************.***********

14. spacer 3.3|562128|38|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MH341451 (Listeria phage PSU-VKH-LP019, complete genome) position: , mismatch: 1, identity: 0.974

ctggtcctgtgctgatgattggcggaaaactagtaaca	CRISPR spacer
ctggtcctgtgctgatgattggcggaaaactagtatca	Protospacer
*********************************** **

15. spacer 4.5|579148|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 1, identity: 0.972

cttcctactttttgacataaaaaataagccgagttg	CRISPR spacer
cttcctactttttgacataaaaaataagccgaattg	Protospacer
********************************.***

16. spacer 4.8|579344|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MH341452 (Listeria phage PSU-VKH-LP040, complete genome) position: , mismatch: 1, identity: 0.971

acgagtatcagcgctaaaagagattgttaagcgcc	CRISPR spacer
acgggtatcagcgctaaaagagattgttaagcgcc	Protospacer
***.*******************************

17. spacer 4.8|579344|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KP399678 (Listeria phage vB_LmoS_293, complete genome) position: , mismatch: 1, identity: 0.971

acgagtatcagcgctaaaagagattgttaagcgcc	CRISPR spacer
acgggtatcagcgctaaaagagattgttaagcgcc	Protospacer
***.*******************************

18. spacer 4.27|580572|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NC_009813 (Listeria phage B054, complete genome) position: , mismatch: 1, identity: 0.971

aaattttttgttgataagcatgcaggagcaaacaa	CRISPR spacer
aaattttttgttgataagcatgcaggagcaaacat	Protospacer
**********************************

19. spacer 4.32|580892|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KY705255 (Streptococcus phage P0095, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

20. spacer 4.32|580892|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KY705251 (Streptococcus phage P0091, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

21. spacer 4.32|580892|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KX879643 (Streptococcus phage CHPC1151, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

22. spacer 4.32|580892|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MK202161 (Streptococcus phage CHPC1282, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

23. spacer 4.32|580892|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KY705252 (Streptococcus phage P0092, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

24. spacer 4.32|580892|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MH937506 (Streptococcus phage CHPC1148, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

25. spacer 4.32|580892|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KY705253 (Streptococcus phage P0093, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

26. spacer 4.32|580892|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KY705254 (Streptococcus phage P0094, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

27. spacer 3.2|562065|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NC_021539 (Listeria phage LP-030-2, complete genome) position: , mismatch: 2, identity: 0.941

aaatcaacgggtaaatatttactcacagagcttc	CRISPR spacer
aaatcaacgggcaaatacttactcacagagcttc	Protospacer
***********.*****.****************

28. spacer 3.2|562065|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to AJ312240 (Bacteriophage PSA complete genome) position: , mismatch: 2, identity: 0.941

aaatcaacgggtaaatatttactcacagagcttc	CRISPR spacer
aaatcaacgggcaaatacttactcacagagcttc	Protospacer
***********.*****.****************

29. spacer 3.3|562128|38|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to DQ003642 (Listeria phage A006, complete genome) position: , mismatch: 2, identity: 0.947

ctggtcctgtgctgatgattggcggaaaactagtaaca	CRISPR spacer
ctggtcctgtgctaatgattggcggaaaactagtatca	Protospacer
*************.********************* **

30. spacer 4.15|579800|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 2, identity: 0.944

gtccacatcgacaataaaaaacacattgtatcactt	CRISPR spacer
gtccacattgacaacaaaaaacacattgtatcactt	Protospacer
********.*****.*********************

31. spacer 4.21|580185|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KJ094022 (Listeria phage LP-030-3, complete genome) position: , mismatch: 2, identity: 0.944

ttgttcgacggcttagacaaccatcacgcttcttta	CRISPR spacer
cttttcgacggcttagacaaccatcacgcttcttta	Protospacer
.* *********************************

32. spacer 4.28|580636|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 2, identity: 0.946

cagtgattatgctaagacctacacaatcgttatcact	CRISPR spacer
cggtgattatgctaagacctacacaatcgttatcatt	Protospacer
*.*********************************.*

33. spacer 4.32|580892|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MN689509 (Lactococcus phage CHPC1175, complete genome) position: , mismatch: 2, identity: 0.946

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaaccgagaacgtgtgttcattatcggacatctta	Protospacer
****** *******.**********************

34. spacer 4.32|580892|37|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MK448735 (Streptococcus phage Javan349, complete genome) position: , mismatch: 2, identity: 0.946

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgggtgttcattgtcggacatctta	Protospacer
************** *********.************

35. spacer 4.8|579344|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to DQ003637 (Listeria phage A500, complete genome) position: , mismatch: 3, identity: 0.914

acgagtatcagcgctaaaagagattgttaagcgcc	CRISPR spacer
acgagtatcagcattaaaagagattgttaagcgtc	Protospacer
************..*******************.*

36. spacer 4.8|579344|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KJ094022 (Listeria phage LP-030-3, complete genome) position: , mismatch: 3, identity: 0.914

acgagtatcagcgctaaaagagattgttaagcgcc	CRISPR spacer
acgagtatcagcattaaaagagattgttaagcgtc	Protospacer
************..*******************.*

37. spacer 3.4|562195|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KP399677 (Listeria phage vB_LmoS_188, complete genome) position: , mismatch: 4, identity: 0.886

gttgaactagaaaaactgcttgcttgggtagatga	CRISPR spacer
atcgaactcgaaaaactacttgcttgggtagatga	Protospacer
.*.***** ********.*****************

38. spacer 3.4|562195|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KP399678 (Listeria phage vB_LmoS_293, complete genome) position: , mismatch: 4, identity: 0.886

gttgaactagaaaaactgcttgcttgggtagatga	CRISPR spacer
atcgaactcgaaaaactacttgcttgggtagatga	Protospacer
.*.***** ********.*****************

39. spacer 4.5|579148|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 4, identity: 0.889

cttcctactttttgacataaaaaataagccgagttg	CRISPR spacer
cttcctactttttgacataaaaaataagccttgctc	Protospacer
******************************  *.*

40. spacer 4.24|580380|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to FW590615 (JP 2010534058-A/25: ANTIBIOTIC RESISTANCE FREE LISTERIA STRAINS AND METHODS FOR CONSTRUCTING AND USING SAME) position: , mismatch: 4, identity: 0.889

gtgtaattcttaattccgtattgattcgctagtttt	CRISPR spacer
ttataatccttaattccgtattgatttgctagtttt	Protospacer
 *.****.******************.*********

41. spacer 4.24|580380|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to HI504184 (Sequence 26 from Patent EP2147092) position: , mismatch: 4, identity: 0.889

gtgtaattcttaattccgtattgattcgctagtttt	CRISPR spacer
ttataatccttaattccgtattgatttgctagtttt	Protospacer
 *.****.******************.*********

42. spacer 4.24|580380|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to AJ417489 (bacteriophage U153 int gene for U153 integrase) position: , mismatch: 4, identity: 0.889

gtgtaattcttaattccgtattgattcgctagtttt	CRISPR spacer
ttataatccttaattccgtattgatttgctagtttt	Protospacer
 *.****.******************.*********

43. spacer 4.18|579993|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NC_022111 (Prevotella sp. oral taxon 299 str. F0039 plasmid, complete sequence) position: , mismatch: 6, identity: 0.824

agaaaaaaaacatctttccaatttgttgttttgc	CRISPR spacer
agcaaaaaaacatctttcctatttgttttatcac	Protospacer
** **************** ******* * *..*

44. spacer 4.33|580958|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MN694189 (Marine virus AFVG_250M578, complete genome) position: , mismatch: 6, identity: 0.829

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
taataaaaaatgagggcttagaaaatgaaaaaatt	Protospacer
*  *.*** ******.***************** *

45. spacer 4.12|579605|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to AP013647 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C72-MedDCM-OCT-S41-C96, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.778

actttagagaaagaaaaacaagaaaaag----taaaactg	CRISPR spacer
tctttagaaaaagaaatacaagaaaaaagatttaaa----	Protospacer
 *******.******* **********.    ****

46. spacer 4.24|580380|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NC_019743 (Microcoleus sp. PCC 7113 plasmid pMIC7113.08, complete sequence) position: , mismatch: 8, identity: 0.778

gtgtaattcttaattccgtattgattcgctagtttt---	CRISPR spacer
gtgtaattcttactgccgtattgatt---taactctgaa	Protospacer
************ * ***********   **..*.*

47. spacer 4.26|580509|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KT070867 (Bacillus phage PBC2, complete genome) position: , mismatch: 8, identity: 0.765

ataaattatccgtatgttcttgaattgtttcttc	CRISPR spacer
ataatttatccatatgttcttgaatcttgtttat	Protospacer
**** ******.*************. * *.* .

48. spacer 4.18|579993|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP038863 (Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

agaaaaaaaacatctttccaatttgttgttttgc-----	CRISPR spacer
aagaaaaaaacatatttccaatt-----ttttccaaaaa	Protospacer
*..********** *********     **** *

49. spacer 4.22|580250|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NC_014533 (Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence) position: , mismatch: 9, identity: 0.743

gcttttttcaacaattttatcaccagatgtcatta	CRISPR spacer
agttttttcaacaattttatgaacagataattttt	Protospacer
. ****************** * *****. . **

50. spacer 4.33|580958|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MK448625 (Streptococcus satellite phage Javan738, complete genome) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
gtatgaactatgaggacttagaaagtgaagacctg	Protospacer
 * **** ****************.****.*

51. spacer 4.33|580958|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MK448449 (Streptococcus satellite phage Javan356, complete genome) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
gtatgaactatgaggacttagaaagtgaagacctg	Protospacer
 * **** ****************.****.*

52. spacer 4.33|580958|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to MK448636 (Streptococcus satellite phage Javan749, complete genome) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
gtctgaactatgaggacttagaaagtgaagacctg	Protospacer
 *.**** ****************.****.*

53. spacer 4.33|580958|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045037 (Lactobacillus mali strain LM596 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
ttaagaaatataaggacttagtaaatgaagttatg	Protospacer
**  *******.********* *******.  *

54. spacer 4.33|580958|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018177 (Lactobacillus hordei strain TMW 1.1822 plasmid pL11822-1, complete sequence) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
ttaagaaatataaggacttagtaaatgaagttatg	Protospacer
**  *******.********* *******.  *

55. spacer 4.33|580958|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018181 (Lactobacillus nagelii strain TMW 1.1827 plasmid pL11827-1, complete sequence) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
ttaagaaatataaggacttagtaaatgaagttatg	Protospacer
**  *******.********* *******.  *

56. spacer 4.12|579605|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP015030 (Pseudomonas putida strain KF715 plasmid pKF715A, complete sequence) position: , mismatch: 11, identity: 0.694

actttagagaaagaaaaacaagaaaaagtaaaactg	CRISPR spacer
gaaaaagagaaagagaaacaagagaaagtaacaagc	Protospacer
.    *********.********.******* *

57. spacer 4.12|579605|36|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018048 (Pseudomonas aeruginosa strain DN1 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.694

actttagagaaagaaaaacaagaaaaagtaaaactg	CRISPR spacer
gaaaaagagaaagagaaacaagagaaagtaacaagc	Protospacer
.    *********.********.******* *

58. spacer 4.25|580445|35|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to AP014250 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S40-C9, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 11, identity: 0.686

ttagagataacgttagcatccgtgataacttagtt	CRISPR spacer
caggttctaacgttagtatccttgataacttaaca	Protospacer
. .*   *********.**** **********..

59. spacer 4.30|580764|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034816 (Paracoccus sp. Arc7-R13 plasmid unnamed6, complete sequence) position: , mismatch: 11, identity: 0.676

caagatatgctagaaatggcgcaaatagcgcgcg	CRISPR spacer
gtccggctgcttgaaatggcgcagatagcgcgtc	Protospacer
    .  **** ***********.********.

60. spacer 4.26|580509|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to NC_031922 (Synechococcus phage S-CAM9 isolate 1109NB16, complete genome) position: , mismatch: 12, identity: 0.647

ataaattatccgtatgttcttgaattgtttcttc	CRISPR spacer
caggattatccgtatcttcttggattgtagaagg	Protospacer
  ..*********** ******.*****

61. spacer 4.26|580509|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KU686204 (Synechococcus phage S-CAM9 isolate 0808SB05, complete genome) position: , mismatch: 12, identity: 0.647

ataaattatccgtatgttcttgaattgtttcttc	CRISPR spacer
caggattatccgtatcttcttggattgtagaagg	Protospacer
  ..*********** ******.*****

62. spacer 4.26|580509|34|NZ_CP020828|PILER-CR,CRISPRCasFinder,CRT matches to KU686205 (Synechococcus phage S-CAM9 isolate 0908SB82, complete genome) position: , mismatch: 12, identity: 0.647

ataaattatccgtatgttcttgaattgtttcttc	CRISPR spacer
caggattatccgtatcttcttggattgtagaagg	Protospacer
  ..*********** ******.*****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

122709 : 129234

Listeria_phage(33.33%)

tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003721739.1\|122709_123162_-	ImmA/IrrE family metallo-endopeptidase	A0A059T7S0	Listeria_phage	4.0e-31	47.9
WP_003721740.1\|123167_123503_-	helix-turn-helix transcriptional regulator	A0A2H4JAR9	uncultured_Caudovirales_phage	4.0e-20	52.5
WP_003732219.1\|123719_124148_+	hypothetical protein	NA	NA	NA	NA
WP_003732220.1\|124159_124576_+	hypothetical protein	A8ASQ1	Listeria_phage	1.3e-20	39.3
WP_009930418.1\|124853_125243_+	DUF5072 domain-containing protein	NA	NA	NA	NA
WP_003721744.1\|125255_125768_+\|tail	phage major tail protein, TP901-1 family	A0A097PBF4	Streptococcus_pyogenes_phage	1.2e-47	62.7
WP_009911446.1\|125815_126118_+	hypothetical protein	NA	NA	NA	NA
WP_009911444.1\|126159_126564_+	hypothetical protein	NA	NA	NA	NA
WP_069007725.1\|126550_128419_+	hypothetical protein	A0A097PAU2	Streptococcus_pyogenes_phage	3.5e-20	45.8
WP_009911828.1\|128415_129234_+\|tail	phage tail family protein	A0A060AFE1	Staphylococcus_phage	7.2e-39	35.0

DBSCAN-SWA_2

1153905 : 1161327

Hokovirus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003721506.1\|1153905_1154289_+	glycerol-3-phosphate cytidylyltransferase	A0A1V0SGE7	Hokovirus	1.4e-16	40.7
WP_003732709.1\|1154310_1155294_+	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	4.1e-12	34.6
WP_058876248.1\|1155308_1156322_+	glycosyltransferase	A0A1V0SAH6	Catovirus	4.6e-11	32.0
WP_003721509.1\|1156530_1158021_+	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	9.5e-114	49.7
WP_003727000.1\|1158032_1158857_+	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	9.7e-68	52.6
WP_061111005.1\|1158869_1159178_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_003730540.1\|1159237_1159642_+	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_010989661.1\|1159770_1161327_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	2.3e-17	28.1

DBSCAN-SWA_3

1251592 : 1356456

108

Listeria_phage(68.42%)

protease,capsid,terminase,portal,tail,integrase,tRNA,holin

attL 1277278:1277299|attR 1318759:1318780

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003736387.1\|1251592_1252645_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2K9L3A8	Tupanvirus	1.3e-29	34.9
WP_069007870.1\|1252644_1255053_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_014600776.1\|1255213_1255915_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.0e-33	35.4
WP_031674597.1\|1255928_1259339_+	FtsX-like permease family protein	NA	NA	NA	NA
WP_069007869.1\|1259436_1259889_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_069007868.1\|1259904_1263105_+	MMPL family transporter	NA	NA	NA	NA
WP_069007867.1\|1263211_1263886_+	uracil-DNA glycosylase	A0A172DS90	Canid_alphaherpesvirus	1.7e-49	47.3
WP_072217174.1\|1263923_1264850_-	ribonuclease HIII	NA	NA	NA	NA
WP_003740576.1\|1265003_1265267_+	cell division protein ZapA	NA	NA	NA	NA
WP_003723849.1\|1265266_1265809_+	CvpA family protein	NA	NA	NA	NA
WP_003723851.1\|1265901_1267614_+	DNA polymerase/3'-5' exonuclease PolX	A0A2H4UV14	Bodo_saltans_virus	5.1e-18	24.8
WP_003732776.1\|1267636_1269994_+	endonuclease MutS2	Q94M10	Lactobacillus_phage	1.0e-21	50.4
WP_003723853.1\|1270074_1270386_+	thioredoxin	A0A1X9I9P5	Staphylococcus_phage	5.4e-19	39.6
WP_014600780.1\|1270461_1272273_+	excinuclease ABC subunit UvrC	NA	NA	NA	NA
WP_003732778.1\|1272461_1273676_+	aspartate kinase	NA	NA	NA	NA
WP_003733801.1\|1273731_1274226_-	YslB family protein	NA	NA	NA	NA
WP_003723856.1\|1274373_1275174_+	glutamate racemase	NA	NA	NA	NA
WP_014601941.1\|1275186_1275933_+	ribonuclease PH	NA	NA	NA	NA
WP_069007866.1\|1275936_1276548_+	XTP/dITP diphosphatase	NA	NA	NA	NA
WP_012951515.1\|1276584_1277109_+	metallophosphoesterase	NA	NA	NA	NA
1277278:1277299	attL	NA	NA	NA	NA
WP_031660124.1\|1277394_1278549_-\|integrase	site-specific integrase	A0A059T688	Listeria_phage	1.1e-207	94.8
WP_003730990.1\|1278680_1279295_-	hypothetical protein	A0A059T7Z1	Listeria_phage	7.7e-78	77.0
WP_003730991.1\|1279345_1279798_-	ImmA/IrrE family metallo-endopeptidase	R4IBK9	Listeria_phage	4.8e-77	90.0
WP_014601389.1\|1279814_1280138_-	helix-turn-helix transcriptional regulator	Q8W5Y0	Listeria_phage	6.3e-39	73.8
WP_025370566.1\|1280981_1281305_+	hypothetical protein	NA	NA	NA	NA
WP_003730994.1\|1281452_1281656_-	hypothetical protein	NA	NA	NA	NA
WP_003730995.1\|1281722_1281914_+	helix-turn-helix transcriptional regulator	A0A059T5F8	Listeria_phage	5.4e-22	87.1
WP_003730996.1\|1281935_1282178_+	hypothetical protein	A8ATD2	Listeria_phage	3.9e-41	93.8
WP_003730997.1\|1282180_1282366_+	hypothetical protein	A8ATD3	Listeria_phage	3.7e-28	98.4
WP_012951522.1\|1283103_1283346_+	hypothetical protein	NA	NA	NA	NA
WP_003731843.1\|1283631_1283847_+	hypothetical protein	NA	NA	NA	NA
WP_069007865.1\|1283924_1284476_+	DUF1642 domain-containing protein	Q8W5X2	Listeria_phage	2.7e-37	45.0
WP_009912778.1\|1284534_1285050_+	hypothetical protein	C9E2P0	Enterococcus_phage	1.8e-32	45.5
WP_068997557.1\|1285228_1285699_+	DUF1642 domain-containing protein	R4IBV9	Listeria_phage	2.5e-28	69.2
WP_031669126.1\|1285699_1286122_+	hypothetical protein	Q8W5W4	Listeria_phage	1.5e-69	95.0
WP_012951535.1\|1286288_1286672_+	hypothetical protein	A8ATE8	Listeria_phage	5.3e-61	92.9
WP_003731665.1\|1286673_1287153_+	siphovirus Gp157 family protein	R4IBM0	Listeria_phage	7.6e-57	76.7
WP_012951536.1\|1287172_1287862_+	AAA family ATPase	R4IDY8	Listeria_phage	3.1e-128	96.9
WP_077310975.1\|1287940_1289182_+	DEAD/DEAH box helicase	A8ATF1	Listeria_phage	1.2e-207	92.4
WP_069007862.1\|1289206_1289692_+	DUF669 domain-containing protein	A0A059T5G4	Listeria_phage	1.6e-86	97.5
WP_069011928.1\|1289714_1291988_+	DNA primase	R4IBW2	Listeria_phage	0.0e+00	94.8
WP_031669964.1\|1292322_1292637_+	VRR-NUC domain-containing protein	Q8W5V6	Listeria_phage	1.7e-52	98.1
WP_031659886.1\|1292749_1293283_+	DUF3310 domain-containing protein	A8ATF5	Listeria_phage	2.2e-76	78.9
WP_003731655.1\|1293500_1293728_+	hypothetical protein	NA	NA	NA	NA
WP_009917712.1\|1293740_1294166_+	DUF722 domain-containing protein	A0A059T6H4	Listeria_phage	8.0e-74	100.0
WP_031669127.1\|1294263_1295007_+	DUF559 domain-containing protein	NA	NA	NA	NA
WP_026749920.1\|1295466_1295793_+	hypothetical protein	A0A059T5G5	Listeria_phage	8.3e-55	98.1
WP_009928009.1\|1295792_1296107_+	HNH endonuclease	A8ATF8	Listeria_phage	3.8e-57	99.0
WP_061107421.1\|1296155_1296512_+	hypothetical protein	A8AT94	Listeria_phage	2.0e-46	99.0
WP_061107420.1\|1296508_1298152_+\|terminase	terminase large subunit	A8AT95	Listeria_phage	0.0e+00	98.7
WP_069011925.1\|1298163_1299294_+\|portal	phage portal protein	A0A059T6F0	Listeria_phage	2.3e-213	98.7
WP_061107162.1\|1299290_1300088_+\|protease	Clp protease ClpP	A0A059T5F2	Listeria_phage	2.6e-134	93.6
WP_061107418.1\|1300114_1301266_+\|capsid	phage major capsid protein	A8AT98	Listeria_phage	2.7e-201	93.0
WP_003731645.1\|1301452_1301752_+	hypothetical protein	A8ATA0	Listeria_phage	5.3e-48	100.0
WP_045552979.1\|1301735_1302101_+	hypothetical protein	A8ATA1	Listeria_phage	2.3e-61	94.2
WP_045552980.1\|1302097_1302499_+	hypothetical protein	A8ATA2	Listeria_phage	2.0e-66	97.0
WP_012581455.1\|1302899_1303487_+\|tail	phage tail protein	A8ATA4	Listeria_phage	4.0e-108	100.0
WP_069011922.1\|1304104_1309030_+\|tail	phage tail tape measure protein	A0A059T5F4	Listeria_phage	0.0e+00	95.7
WP_023553822.1\|1309022_1310672_+\|tail	phage tail protein	A0A059T682	Listeria_phage	0.0e+00	99.6
WP_031669134.1\|1310684_1312979_+	hypothetical protein	A0A059T7Y6	Listeria_phage	0.0e+00	98.3
WP_077600797.1\|1312968_1314060_+	carbohydrate-binding protein CenC	A0A059T7R4	Listeria_phage	2.2e-192	93.4
WP_003722523.1\|1314098_1314464_+	hypothetical protein	Q9T1A0	Listeria_phage	7.4e-12	100.0
WP_003722522.1\|1314476_1314758_+\|holin	holin	A8ASL4	Listeria_phage	3.4e-41	94.6
WP_033919168.1\|1314757_1315603_+	peptidase M15	A0A059T7Y8	Listeria_phage	2.6e-140	95.8
WP_060869024.1\|1315759_1316662_+	ATP-binding protein	J7KDG8	Streptococcus_phage	2.0e-37	33.1
WP_031667948.1\|1316655_1316955_+	STAS-like domain-containing protein	NA	NA	NA	NA
WP_003723291.1\|1317029_1317479_-	anti-CRISPR protein AcrIIA1	Q9T196	Listeria_phage	1.3e-71	94.6
WP_003723290.1\|1317483_1317747_-	anti-CRISPR protein AcrIIA4	A0A2D0TCG7	unidentified_phage	1.9e-41	100.0
WP_069007859.1\|1318259_1318493_+	hypothetical protein	A8ATC5	Listeria_phage	3.1e-35	96.1
WP_069007858.1\|1319140_1320499_+	DUF1254 domain-containing protein	NA	NA	NA	NA
1318759:1318780	attR	NA	NA	NA	NA
WP_023548894.1\|1320539_1321133_-	hypothetical protein	NA	NA	NA	NA
WP_009914084.1\|1321286_1321694_-	glyoxalase/bleomycin resistance/extradiol dioxygenase family protein	NA	NA	NA	NA
WP_031674609.1\|1321858_1322458_+	histidine phosphatase family protein	A0A1X9IGJ2	Lactococcus_phage	1.2e-30	41.5
WP_003723543.1\|1322489_1322750_-	hypothetical protein	NA	NA	NA	NA
WP_069007857.1\|1322873_1324283_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	8.3e-51	31.8
WP_003723545.1\|1324310_1324574_+	DUF3116 domain-containing protein	NA	NA	NA	NA
WP_003723546.1\|1324741_1325218_+	8-oxo-dGTP diphosphatase	NA	NA	NA	NA
WP_003723547.1\|1325255_1325501_-	hypothetical protein	NA	NA	NA	NA
WP_003732784.1\|1325497_1326703_-	MFS transporter	NA	NA	NA	NA
WP_003723549.1\|1326907_1327567_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_003723550.1\|1327608_1327803_-	hypothetical protein	NA	NA	NA	NA
WP_003723551.1\|1327869_1328718_-	YitT family protein	NA	NA	NA	NA
WP_003732787.1\|1329336_1330050_+	trehalose operon repressor	NA	NA	NA	NA
WP_031664857.1\|1330080_1331727_-	alpha,alpha-phosphotrehalase	NA	NA	NA	NA
WP_003723556.1\|1331745_1333230_-	PTS system trehalose-specific EIIBC component	NA	NA	NA	NA
WP_003723557.1\|1333345_1333798_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_003723558.1\|1333844_1334309_-	hypothetical protein	NA	NA	NA	NA
WP_003723559.1\|1334497_1335418_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_014931389.1\|1335437_1336685_-	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	7.2e-107	51.8
WP_003723561.1\|1336668_1337499_-	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	4.3e-47	42.4
WP_003732792.1\|1337634_1338774_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_014931390.1\|1338854_1339250_-	helix-turn-helix transcriptional regulator	A9D9J6	Lactobacillus_prophage	1.3e-14	57.4
WP_003727524.1\|1339400_1339616_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014931391.1\|1339734_1340268_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_003732795.1\|1340285_1340951_+	hypothetical protein	NA	NA	NA	NA
WP_014601429.1\|1341212_1341566_+	hypothetical protein	NA	NA	NA	NA
WP_140442807.1\|1341847_1342150_+	hypothetical protein	NA	NA	NA	NA
WP_003723884.1\|1342264_1343548_+	trigger factor	NA	NA	NA	NA
WP_069007856.1\|1343732_1344992_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.0e-145	63.2
WP_134799498.1\|1345127_1345676_+	type I signal peptidase SipX	NA	NA	NA	NA
WP_003723888.1\|1345710_1346280_+	type I signal peptidase SipY	NA	NA	NA	NA
WP_003723889.1\|1346381_1346924_+	type I signal peptidase SipZ	NA	NA	NA	NA
WP_003723892.1\|1348710_1349571_+	DNA-protecting protein DprA	NA	NA	NA	NA
WP_009924617.1\|1349842_1351921_+	type I DNA topoisomerase	A0A1V0SB35	Catovirus	1.4e-107	37.7
WP_009924616.1\|1351983_1353288_+\|tRNA	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	NA	NA	NA	NA
WP_009911635.1\|1353570_1354473_+	tyrosine recombinase XerC	A0A097EYL9	Mycobacterium_phage	1.2e-13	28.6
WP_003724001.1\|1354493_1355033_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_061387996.1\|1355046_1356456_+\|protease	ATP-dependent protease ATPase subunit HslU	W6AS21	Erwinia_phage	7.5e-44	27.8

DBSCAN-SWA_4

1886789 : 1895075

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_031665594.1\|1886789_1887356_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.0e-25	35.9
WP_031665593.1\|1887352_1888402_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	9.2e-63	44.4
WP_031665592.1\|1888420_1889848_-	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	1.4e-53	31.9
WP_085379164.1\|1889832_1892052_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.4e-158	41.0
WP_003733240.1\|1892044_1892728_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_003722248.1\|1892731_1892977_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_014931516.1\|1892988_1893702_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	8.8e-41	37.8
WP_003729814.1\|1893782_1895075_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	2.5e-17	33.0

DBSCAN-SWA_5

2555973 : 2563817

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003722604.1\|2555973_2556945_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	5.2e-52	39.4
WP_003722605.1\|2556952_2557921_-	YvcK family protein	A1IMD5	Streptococcus_phage	6.7e-68	43.3
WP_010990001.1\|2557922_2558798_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.2e-08	29.7
WP_069007711.1\|2558905_2560636_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	3.0e-175	54.0
WP_009930954.1\|2560677_2561739_-	galactose mutarotase	NA	NA	NA	NA
WP_009924988.1\|2561755_2562739_-	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	2.6e-51	37.2
WP_003722610.1\|2562857_2563817_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.0e-88	53.7

Anti-CRISPR protein detection

Acr_ID: NZ_CP020828.1|WP_003723290.1|1317483_1317747_-|anti-CRISPR-protein-AcrIIA4

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP020828.1|WP_003723290.1|1317483_1317747_-|anti-CRISPR-protein-AcrIIA4

1317483_1317747_-

87 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|14	1.0	1	1.0

1251592-1356456

2. NZ_CP020829

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

12391 : 50887

Streptococcus_phage(26.67%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_031641563.1\|12391_12718_+	hypothetical protein	A0A2K9V3N4	Faecalibacterium_phage	3.2e-06	40.8
WP_003731676.1\|12717_13380_+	DUF2786 domain-containing protein	NA	NA	NA	NA
WP_003728521.1\|13392_13776_+	DUF3850 domain-containing protein	C9E2N9	Enterococcus_phage	2.2e-14	53.4
WP_031669356.1\|13934_14423_+	hypothetical protein	NA	NA	NA	NA
WP_096832442.1\|15025_17203_+	hypothetical protein	A0A1B1IUG5	uncultured_Mediterranean_phage	1.2e-19	25.0
WP_003728511.1\|17416_18025_+	recombinase family protein	A0A1W5LU24	Ralstonia_phage	1.0e-21	42.9
WP_003728510.1\|18014_18242_+	hypothetical protein	NA	NA	NA	NA
WP_003731679.1\|18361_18640_-	hypothetical protein	NA	NA	NA	NA
WP_003728509.1\|18602_18839_+	helix-turn-helix transcriptional regulator	A0A097PBE6	Streptococcus_pyogenes_phage	6.7e-14	53.4
WP_003728507.1\|19266_21381_+\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	3.4e-117	39.1
WP_013315188.1\|21655_22996_+\|transposase	IS3 family transposase	A0A0C5AC89	Paenibacillus_phage	1.1e-31	38.6
WP_003728505.1\|23170_23905_+	AAA family ATPase	NA	NA	NA	NA
WP_003728504.1\|24109_24454_+	hypothetical protein	NA	NA	NA	NA
WP_077418289.1\|24441_25722_+	Y-family DNA polymerase	O64031	Bacillus_phage	4.0e-92	45.1
WP_003726389.1\|26086_26419_-	hypothetical protein	NA	NA	NA	NA
WP_026747205.1\|26411_27257_-	ParA family protein	F0PIG8	Enterococcus_phage	3.4e-52	42.6
WP_012952135.1\|27919_29569_+	plasmid replication protein	NA	NA	NA	NA
WP_031669350.1\|30537_33453_-\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	3.2e-174	36.7
WP_003728468.1\|33456_34011_-	recombinase family protein	A0A0F7LA37	Escherichia_phage	7.0e-38	53.4
WP_003728467.1\|34290_34650_+	Cd(II)-sensing metalloregulatory transcriptional repressor CadC	E4ZFI8	Streptococcus_phage	3.1e-26	50.0
WP_003728466.1\|34649_36785_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.6e-247	64.5
WP_012952148.1\|37484_37676_+	hypothetical protein	NA	NA	NA	NA
WP_031669346.1\|37682_38069_+	hypothetical protein	NA	NA	NA	NA
WP_077418284.1\|38084_39344_+	type II/IV secretion system ATPase subunit	NA	NA	NA	NA
WP_031669342.1\|39315_40128_+	hypothetical protein	NA	NA	NA	NA
WP_009912433.1\|40127_40901_+	hypothetical protein	NA	NA	NA	NA
WP_012952153.1\|40901_41258_+	hypothetical protein	NA	NA	NA	NA
WP_009911416.1\|41653_41896_+	hypothetical protein	NA	NA	NA	NA
WP_012952155.1\|41949_42153_+	hypothetical protein	NA	NA	NA	NA
WP_031669339.1\|42169_42808_+	hypothetical protein	NA	NA	NA	NA
WP_031669337.1\|42819_43323_+	DUF669 domain-containing protein	NA	NA	NA	NA
WP_009911422.1\|43420_43606_+	hypothetical protein	NA	NA	NA	NA
WP_012952158.1\|43629_43917_+	hypothetical protein	NA	NA	NA	NA
WP_072240426.1\|44002_44704_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_157105794.1\|44724_44886_+	hypothetical protein	NA	NA	NA	NA
WP_002354485.1\|44919_45606_-\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	2.0e-127	99.6
WP_069007946.1\|45637_45913_-	hypothetical protein	NA	NA	NA	NA
WP_077951035.1\|46272_46380_+	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	NA	NA	NA	NA
WP_009917198.1\|47056_47401_-	quaternary ammonium compound efflux SMR transporter BcrC	NA	NA	NA	NA
WP_003725293.1\|47418_47736_-	quaternary ammonium compound efflux SMR transporter BcrB	NA	NA	NA	NA
WP_003725294.1\|47747_48287_-	efflux transporter transcriptional regulator BcrA	NA	NA	NA	NA
WP_069007945.1\|48838_49429_+	hypothetical protein	NA	NA	NA	NA
WP_157105795.1\|49958_50102_-	hypothetical protein	NA	NA	NA	NA
WP_002354485.1\|50200_50887_-\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	2.0e-127	99.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP020828

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

2. NZ_CP020829

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection