CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP017689	Thalassotalea crassostreae strain LPB0090 chromosome, complete genome	5 crisprs	cas3,DEDDh,csa3,DinG	0	0	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP017689_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017689_1

1155337-1155489

Orphan

Consensus_repeat	Method
AATGCCGCGGTCACATGGACGTGAAAGAGCGGTCTTACATCCTGTAAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017689_1

>merge|NZ_CP017689|1|1155337-1155489|CRISPRCasFinder
AATGCCGCGGTCACATGGACGTGAAAGAGCGGTCTTACATCCTGTAAGGCGTCAAAAAATTAAACATCCATGTATTTTTTGCATACGATGTATAGGACATACAAATGCCGAGGTCACATGGACGTGAAAGAGCGGTCTTACATCCTGTAAGGC

>NZ_CP017689|1|1|1155337-1155489|CRISPRCasFinder
AATGCCGCGGTCACATGGACGTGAAAGAGCGGTCTTACATCCTGTAAGGC	GTCAAAAAATTAAACATCCATGTATTTTTTGCATACGATGTATAGGACATACA
AATGCCGAGGTCACATGGACGTGAAAGAGCGGTCTTACATCCTGTAAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017689.1\|WP_068546916.1\|1152059_1152401_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|226219
NZ_CP017689.1\|WP_068546904.1\|1165438_1165735_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017689.1\|WP_068546906.1\|1162196_1162655_-\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|234575
NZ_CP017689.1\|WP_068546918.1\|1149713_1150388_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187586
NZ_CP017689.1\|WP_068546936.1\|1163734_1165177_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237673
NZ_CP017689.1\|WP_068546905.1\|1162654_1163671_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224616
NZ_CP017689.1\|WP_082897206.1\|1152802_1153597_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP017689.1\|WP_068546917.1\|1150518_1152042_+\|VCBS-repeat-containing-protein	unknown	unknown	unknown
NZ_CP017689.1\|WP_068546921.1\|1146013_1147261_+\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|224771
NZ_CP017689.1\|WP_068546922.1\|1145331_1145967_+\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|225418
NZ_CP017689.1\|WP_068546912.1\|1155637_1156096_-\|Hsp20-family-protein	unknown	unknown	gnl\|CDD\|182691
NZ_CP017689.1\|WP_068546910.1\|1157135_1157726_-\|thiol-peroxidase	unknown	unknown	gnl\|CDD\|239312
NZ_CP017689.1\|WP_068546908.1\|1159664_1161206_-\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP017689.1\|WP_068546920.1\|1147262_1148765_+\|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl\|CDD\|163517
NZ_CP017689.1\|WP_157726642.1\|1153639_1154854_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|274866
NZ_CP017689.1\|WP_068546907.1\|1161283_1162165_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226910
NZ_CP017689.1\|WP_068546911.1\|1156430_1157045_+\|DUF924-domain-containing-protein	unknown	unknown	gnl\|CDD\|377592
NZ_CP017689.1\|WP_068546915.1\|1152407_1152659_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017689.1\|WP_068546919.1\|1148916_1149465_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP017689.1\|WP_068546909.1\|1157842_1159516_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238625

Protein	Function_ID	Function_description	E-value
NZ_CP017689.1\|WP_068546916.1\|1152059_1152401_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	3.55357e-29
NZ_CP017689.1\|WP_157726642.1\|1153639_1154854_-\|glycosyltransferase	gnl\|CDD\|274866	TIGR03937, Poly-beta-16-N-acetyl-D-glucosamine_synthase, poly-beta-1,6 N-acetyl-D-glucosamine synthase. Members of this protein family are biofilm-forming enzymes that polymerize N-acetyl-D-glucosamine residues in beta(1,6) linkage. One named members is IcaA (intercellular adhesin protein A), an enzyme that acts (with aid of subunit IcaD) in Polysaccharide Intercellular Adhesin (PIA) biosynthesis in Staphylococcus epidermis). The homologous member in E. coli is designated PgaC. Members are often encoded next to a polysaccharide deacetylase and involved in biofilm formation. Note that chitin, although also made from N-acetylglucosamine, is formed with beta-1,4 linkages.	6.90642e-59
NZ_CP017689.1\|WP_068546906.1\|1162196_1162655_-\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	3.18987e-56
NZ_CP017689.1\|WP_068546936.1\|1163734_1165177_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237673	PRK14325, PRK14325, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NZ_CP017689.1\|WP_068546905.1\|1162654_1163671_-\|PhoH-family-protein	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	6.45991e-162
NZ_CP017689.1\|WP_082897206.1\|1152802_1153597_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	8.18736e-24
NZ_CP017689.1\|WP_068546918.1\|1149713_1150388_+\|SDR-family-oxidoreductase	gnl\|CDD\|187586	cd05325, carb_red_sniffer_like_SDR_c, carbonyl reductase sniffer-like, classical (c) SDRs. Sniffer is an NADPH-dependent carbonyl reductase of the classical SDR family. Studies in Drosophila melanogaster implicate Sniffer in the prevention of neurodegeneration due to aging and oxidative-stress. This subgroup also includes Rhodococcus sp. AD45 IsoH, which is an NAD-dependent 1-hydroxy-2-glutathionyl-2-methyl-3-butene dehydrogenase involved in isoprene metabolism, Aspergillus nidulans StcE encoded by a gene which is part of a proposed sterigmatocystin biosynthesis gene cluster, Bacillus circulans SANK 72073 BtrF encoded by a gene found in the butirosin biosynthesis gene cluster, and Aspergillus parasiticus nor-1 involved in the biosynthesis of aflatoxins. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.99346e-73
NZ_CP017689.1\|WP_068546910.1\|1157135_1157726_-\|thiol-peroxidase	gnl\|CDD\|239312	cd03014, PRX_Atyp2cys, Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a bacterial periplasmic peroxidase which differs from other PRXs in that it shows substrate specificity toward alkyl hydroperoxides over hydrogen peroxide. As with all other PRXs, the peroxidatic cysteine (N-terminal) of Tpx is oxidized into a sulfenic acid intermediate upon reaction with peroxides. Tpx is able to resolve this intermediate by forming an intramolecular disulfide bond with a conserved C-terminal cysteine (the resolving cysteine), which can then be reduced by thioredoxin. This differs from the typical 2-cys PRX which resolves the oxidized cysteine by forming an intermolecular disulfide bond with the resolving cysteine from the other subunit of the homodimer. Atypical 2-cys PRX homodimers have a loop-based interface (A-type for alternate), in contrast with the B-type interface of typical 2-cys and 1-cys PRXs.	6.36073e-71
NZ_CP017689.1\|WP_068546922.1\|1145331_1145967_+\|c-type-cytochrome	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	1.88993e-14
NZ_CP017689.1\|WP_068546912.1\|1155637_1156096_-\|Hsp20-family-protein	gnl\|CDD\|182691	PRK10743, PRK10743, heat shock chaperone IbpA.	6.96805e-54
NZ_CP017689.1\|WP_068546908.1\|1159664_1161206_-\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	5.71068e-180
NZ_CP017689.1\|WP_068546920.1\|1147262_1148765_+\|right-handed-parallel-beta-helix-repeat-containing-protein	gnl\|CDD\|163517	TIGR03805, beta_helix_1, parallel beta-helix repeat-containing protein. Members of this protein family contain a tandem pair of beta-helix repeats (see TIGR03804). Each repeat is expected to consist of three beta strands that form a single turn as they form a right-handed helix of stacked beta-structure. Member proteinsa occur regularly in two-gene pairs along with another uncharacterized protein family; both protein families exhibit either lipoprotein or regular signal peptides, suggesting transit through the plasma membrane, and the two may be fused. The function of the pair is unknown. [Unknown function, General].	7.35717e-58
NZ_CP017689.1\|WP_068546921.1\|1146013_1147261_+\|c-type-cytochrome	gnl\|CDD\|224771	COG1858, MauG, Cytochrome c peroxidase [Inorganic ion transport and metabolism].	1.85247e-80
NZ_CP017689.1\|WP_068546907.1\|1161283_1162165_-\|CBS-domain-containing-protein	gnl\|CDD\|226910	COG4535, CorC, Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism].	1.25164e-129
NZ_CP017689.1\|WP_068546911.1\|1156430_1157045_+\|DUF924-domain-containing-protein	gnl\|CDD\|377592	pfam06041, DUF924, Bacterial protein of unknown function (DUF924). This family consists of several hypothetical bacterial proteins of unknown function. Structurally, this family resembles TPR-like repeats.	1.21517e-83
NZ_CP017689.1\|WP_068546919.1\|1148916_1149465_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	4.43993e-29
NZ_CP017689.1\|WP_068546909.1\|1157842_1159516_-\|amidohydrolase-family-protein	gnl\|CDD\|238625	cd01300, YtcJ_like, YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.	1.84258e-164

>NZ_CP017689.1|WP_157726642.1|1153639_1154854_-|glycosyltransferase
MNLVRIVLFMLLLPLLIKYITQLVALCFYPRINNKHNIDEQNLPSVSILVPAYNEEVGITKTLRSVVNTHYNKLQIIVINDGSTDNTDDIISEFQRQHQQSDSLIEFIYLSITNAGKANALNHALKSATGDIIMTIDGDCLIDKDAVINTVKHFHQENVAAVAGNVVIGNKRRSIEIMQQLEYLFGFFLRRADSVFNAVFIIGGAAAAYRHSVLKKLGGFNHDIVTEDIEMSLRILNAGYRTRYAADAITYTEGPSDWRGLFNQRLRWKFGRFQTLLKFKNMFFSVDTKHSVYLTWLVLPLAIYGEVILMLEAVIISLFYGYSVYYNDYLPILTMIGFISVLLCLQVFLDSKPKYHRNLIMLAPVAWLIFYIVDIVELQALYRSLKRLLRKQSLTWQKWIRVGL
>NZ_CP017689.1|WP_082897206.1|1152802_1153597_+|alpha/beta-fold-hydrolase
MMKEKILPGIKVTGDGPAVLFLHSSLSSSKQWQPLISVLSDSFRCINVDLLGYGRAPQVSNPDNYSLATELNRIFNALEHIIGNHPFHLVGHSFGGANALKIAVENPKRILSLSLYEPVAFHLLEEGTDVRARVIDFANTVARLDAESAARHFTDMWNSKGFFDSLPRKMQTLMSDDIAKVNLDFIGLISEKYGLQECQIVTCPVTLIHGSQSPDISREIIDRLANSFSNVIEYEIDAGHMAPISHAEQVASIINNAIRGGDNF
>NZ_CP017689.1|WP_068546915.1|1152407_1152659_-|hypothetical-protein
MAKPNKKLPQKSVDIQCSSCKARLFKYKKGGKGALIKCFKERIVKDYTVTPCTCPNCQSVFARETLVRGTPAYKIVGNKVSYK
>NZ_CP017689.1|WP_068546916.1|1152059_1152401_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MANPDYEKIWQTVRLIPVGKIACYGQVADLAGLPGRARMVGRALGDAPSTMEVPWHRVINSQGKISFPIGSEHFEKQKGLLQSEDVVVINGRIKLGQFQWQPDLAELLFTLKY
>NZ_CP017689.1|WP_068546917.1|1150518_1152042_+|VCBS-repeat-containing-protein
MPYFGKFTLLLSTLLGSLLLAPMATAQINFNHFQVNAPFNISQEPIRVNLLTNKGKEIIVIGDKDGQAKLALFAFDEAEQSYQLQVNVDLPKTLFAYDYHDSHLESEKQADLPLQHLYFLSSDSVVQFTPNNEQVFTDVADVESIYINQQTPYLRRLSFLEDINADGLDDIILPDFRTINVFINQDIGGFVRNSLPVFPTVEIFSNGITYTEQRYFLADANFDQKLDILLVENNQLVVYQQDNNSFETGPIYIDLKQPISGVNWWDDRGADGNSLDQSDLKHRMVERIEDINGDGIVDLVVRYTQSSGVLERQNDYEIYLGKEQNKQLVYTNKAHTTIKSEGTLAGLNIVDLNNDKQQEIVLSSFDISVSQIIGALLSGSVDQDVLIFSLDKNQTYKERVSKQVQLKFSLSSGKSGSPVVALADLNGDGVKDLILSSDDDELSIYPGNRKTGLVGRDYQQLDIRLPTNGVLLITDDLDYDGRDEMIIRYGSEDGESKQNRLLIVEAK
>NZ_CP017689.1|WP_068546918.1|1149713_1150388_+|SDR-family-oxidoreductase
MSEQARTIVITGANRGIGLAMATQFVANGDNVVALCRESSEALAALNIEVITNVELTNQQSLDMVSEKLKGRCIDLLINNAGILKNETLSDLNSQTITEQFLVNALAPLKLTQALLNNLFDGSKVAFITSRMGSISDNGSGGRYGYRMSKAALNIAAVSLAKDLAPNNIAIGIFHPGYVQTDMTGQRGEITTKQSATGLIKLMDKLSLENSGEFFHSNGQALPW
>NZ_CP017689.1|WP_068546919.1|1148916_1149465_-|GNAT-family-N-acetyltransferase
MIELPTLETSSLILRPVSSEDWPVVLEIQSNKELQRHVKEILDLEAIKAMYNELLEPWQAEDNQWTMFVAVEKATDQPIGAFSLRIVSKYHGNAEMGYIILTNHQRKGFASEGALAVKDYIFNHLNVRRIEAICNVDNIASWKIMEKIGLQREALQRSNYRIYDTWYDSYIYAALNPSLKLT
>NZ_CP017689.1|WP_068546920.1|1147262_1148765_+|right-handed-parallel-beta-helix-repeat-containing-protein
MSKGKILSLVLVAGAFAVGNYYGGINSDPVITASGGASFQGGYDKSQDSSVDAQVITPIAGETRIVNEGESIMAAVKAANPGDTIQVMPGSYHETVYIDKENITIRGVIKAGERATLDGKGVLNDAILYSGNNFVVENMKITGYKGNGIMGQAGNNFIIRNNLIVDTGVYGIFPQLGKNGIVNHNIISGIEDAAIYVGMSDNIQVAHNEVFDSVAGIEIENSRHAIVENNYVHDNTGGILAFITPGLPIKTTYDVIIRNNFVVNNNHKNFAIPGSTVSMIPAGSGIIIWAADDVIVEGNIITNNKTGGIIIADHNSFGTGSNDPDSEPNPDRTMILDNFMVNNGYDSIDEVKALLLAEFKGTDKADIIRVGPGVDSCIINRHRYTTAGVSDWKECDFTNTNNIKTYLLDKPVPPRVIDPTERGKIAYLGICAGCHTYTDRMIGPPVNIIQALYMDNPQGIADFIAKPTKKREDYPEMPPQDYLDVETRLAVAEYMLKVKN
>NZ_CP017689.1|WP_068546921.1|1146013_1147261_+|c-type-cytochrome
MKSFIFYLSVLLMSLASVNSYANDGEFELSSNCPPSFELTEQGVCKLLNMYQFYDSVQGRGLGGTQTSLPDHRDGFTPEQIDLGRFLFFDPALSKDGSISCASCHQPDKGFSDDLDRSVGITGEKVARSAPTLWNVAFLDKFFWDGRSDTLEAQAIGPLFDPKEMGNTPEHLITSLSSIDTYQQMFATAFEDKQISVENISAALAAFQSTLISLNSRYDRYAHGYHQALTENEIKGLNIFRSFVARCAECHQPPLFTNNQIAVIGTEDPEGMPFDVGAEKTFNNKSNRGGFKVPTLRNIAKTAPYMHSGGYKTLREATEFYNKGRGHGIPEGEELIIHWHIWEPNLQDEEIDLIVEFLHTLNDESLMPATPDRVPSGLPVIDAKIAQLKQQQKQPIQQQKNKPENHKQQQVMGGE
>NZ_CP017689.1|WP_068546922.1|1145331_1145967_+|c-type-cytochrome
MSTICKRVFVFITLTLMSVFSVSAKAADTEEGKKLYQSCVACHGDQGQGVDDLNGAALAGQYEWYLKRQLTFYKTGVRGSKPDDVIGQQMSAMSTILSEADIENVSAYLASLPVVTKVEAVAGDAAKGDNKYNAQCGACHGPDAKGNVSLNAPNLSMLSAKYLTQQMKSFQKDLRGFHQDDKYGRQMKMMANTVTNDKDLNDIVAYIKSLK
>NZ_CP017689.1|WP_068546912.1|1155637_1156096_-|Hsp20-family-protein
MRTISKDFSPLYRSFIGAEHLASLMEKASRAEKQPAYPPYNIESIADDKYRITMAVAGFVEAELDIESEENSLTVTGIKAPQDGDENRTFVYQGIAERNFERKFQIADHVKVIAAHMENGLLHIDLEREIPEALKPRKIAIHSKSLLEGDTK
>NZ_CP017689.1|WP_068546911.1|1156430_1157045_+|DUF924-domain-containing-protein
MNGNISKVLDFWFGEINDQLSDDKQTILWYQSTNEMDENIRNEFEHLYEQAFSGQLTSWLDTAQGCMALIILLDQMPRNMYRGSAQAFASDHLALDYCLLGLNKGYDKLLPLVQRCFFYHPLEHAEDIELQQLCVTEFQRLQQVYNGEKQQLFIRNGLEFAKKHLEIIEQFGRFPYRNEVLGRESIKEELEFLKTGVNFGQSKS
>NZ_CP017689.1|WP_068546910.1|1157135_1157726_-|thiol-peroxidase
MKKLLSLTIAAAMCCSTLAFAEEVTESTGLVVAGGKPITLIGKQVYKGNTAPNFKVVDERFTKVKLSDFAGKTVVVSVVPSLDTGVCSLQTKRFNEEVANLPDNIVMLTISNDLPFAQKRFCKTEGVESIKVLSDSVWRDFGHKYGLLIKDMGLLSRSIFVIDKSGKIFYKELVADISTHPDYDAALVAAKEANSL
>NZ_CP017689.1|WP_068546909.1|1157842_1159516_-|amidohydrolase-family-protein
MNKYLAPILVFALLLTSPSSLAKTKIIYNVNGYTLTGNAQDNSGELTKFHALQINNDIIEKIYSHGEKLPNDSKIERVDGHGNTMLPGLIDAHGHVKSYGLSLMQVKLEQTISEQDAVEKAKQYQLENPTLTWIEGRGWNQVNWPDKQFPSKQLLDKYFPDTPVLLRRVDGHAIWVNSKAMEIAGVNRSTADLPGGQILKDDQGEPTGVFIDNAMSLIYKAKPKLNQDELEHVLFTAMTSLASKGLTSVHDAGIDLANITAYQALVKQNRMPIRVNAMVDVKDKNWLNTLAKGPYKSADNMLAINSVKISVDGALGSRGAALVEDYSDLPHHKGLLLYSPEQLTSVMKTAMEFGFQVNTHAIGDNANKQALDNYQTLIEQTNSKHLRHRIEHAQVLLPADIVRFKQMNIIASMQATHATSDKNMAEDRIGQHRIKSAYAWRTLLDNKIMIAAGSDFPVEYPNPFFGLHASVTRQDKDNQPNGGWYGEQRMNLQEALQSFTLNAAYAGHQEHIIGSLEVGKKADFILIKDDIFNIEPSTIWQIPVEQTWVNGETVRIK
>NZ_CP017689.1|WP_068546908.1|1159664_1161206_-|apolipoprotein-N-acyltransferase
MNNKTSLLSIEHSLWKRYVPNFLLGAIMVFSYAPFSLWFVSIAALSIWIYLLNEQDKKQAFRSAFAFGLGFFGVGISWVHVSIEQFGGLPLIVSILLMVLLCAYLALFTGLAAYLAARFNQNKVSLVYLPFTWLIAETLRGVVLTGFSWLSIGYSQIDGPFAALAPIIGEIGISFIVILIACLLVSIVNKQRLKLNSAILASVVIVTIIASQLSFVEKTGKVINTALVQGNIKQELRWDKQAEQNIIDLYIDQTTELYKNNDLIIWPEAAIPRLEPLSQDILSKLNHEAAQANTALITGIINYEPDSSAFFNRLIVLGNKNVDDNEGDYYWRNSNHYDKHHLLPIGEFIPFQELLRPIAPLFNLPMSSFSRGDYVQKNLIANGIQIAPLICFEVVFSKQLAANFDNDTEILLTVSNDAWFGASHGPDQHLEIARMRALEYARPMLRATNNGLTAVIDHNGRISADIEQFTLSTLQTKVDVVTGTTFYSDYGIHLDKLLFVVFALMLIIRRYRN
>NZ_CP017689.1|WP_068546907.1|1161283_1162165_-|CBS-domain-containing-protein
MSDDNPHSGNGSSKTLMEKIVQVFTGEPKNKEELVEVLNDAQDRDLIKPATKQMLEGVLEVSDMRVRDIMIPRSHMVTIDIEQSVSEFLPTVLESAHSRFPVINDDIDHIEGVLLAKDLLAYGFNADAAEVSLKDIIRPAIIIPESKKVEPLLKEFRQQRYHMAVVVDEYGGVSGLVTIEDILELIVGEIEDEHDDMLEREIRHLSGNVYQVKALTEIDNFNEYFNAGFNEEEADTIGGIVIHQFGHMPNRGESINILGFEFKVVSADKRRIQQLQVAVPKDHEVNGKLADDR
>NZ_CP017689.1|WP_068546906.1|1162196_1162655_-|rRNA-maturation-RNase-YbeY
MATITLDIQRPYQTENLPSDEQFQQWADIALLPYNKDFELTIRVVNNDESQQLNKQYRDKDKPTNVLSFPFEVPDGIELDLLGDLVVAADVVSTEAIDQNKQIHAHWAHMIIHGCLHLLGYDHITQDEAEEMEAIEIRLMAELGHNNPYIAS
>NZ_CP017689.1|WP_068546905.1|1162654_1163671_-|PhoH-family-protein
MSKDNQSHEVLLEPLDNNRLANLCGPLDDNLRKIERRLGVEIGYRGNKFKIHGKEQVCVAVVKLLKDLYVQTAPVKGKVGTVSAEELHLALTELNMLEQETAETAAEFDQMVTIRTKRGVIKPRNENQGEYVQNVLTNDISFGVGVAGTGKTYLAVACAVDALERQEVRRILLTRPAVEAGEKLGFLPGDLSQKVDPYLRPLYDALFEMLGFEKVEKLIERNVIEVAPLAYMRGRTLNDAFIILDESQNTTVEQMKMFLTRIGFNSKAVVTGDITQVDLPRGQRSGLRHAIEVLTDIKGVSFNYFQSKDVVRHPVVGRIVEAYERHESVNTPNAEYKR
>NZ_CP017689.1|WP_068546936.1|1163734_1165177_-|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MSKKLYIKTWGCQMNEYDSQKMADLLDSTHGFIEVKEPEEADVLLLNTCSIREKAQEKVFHQLGRWKNMKNDNPELIIGVGGCVASQEGDAIRQRAPFVDIVFGPQTLHRLPEMINQVNGEHTSVVDVSFPEIEKFDRLPEPKAEGPTAFVSIMEGCSKYCTFCVVPYTRGEEVSRPLDDVLYEIAQLAEQGVREVNLLGQNVNAYRGDTHDGDICRFSDLLRLVATIDGIDRIRYTTSHPVEFTNDIIEAYNDIPELVDHLHLPVQSGSDRILNMMKRNHTAIEYKSKIRALKKVRPELCMSSDFIIGYPGETDADFEATMNLIKAIDFDLSFSFIYSARPGTPAADAIDDVSEETKKQRLQILQDRITQQALSIARRMLGTEQRILVEGPSKKNPMELRGRTENNRIVNFEAPHTVIGQFVDVEITDVYSNSLRGKLVRTEDEMGLRIAHSPADILANQHHGKPNYETDDLGVATFTP
>NZ_CP017689.1|WP_068546904.1|1165438_1165735_-|hypothetical-protein
MNILTKSLIAISLVSSSTFALANTADPQMPVFEVTYVENVDVVKQQTRHLLQQMDYKLTLDISRQARNSIETEILNLAQESNLYAISAKAQTTKLYSE

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Crispr_ID: NZ_CP017689_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017689_2

1171996-1172097

Orphan

Consensus_repeat	Method
GCCACGTCCGCAATTTGATTTTTATTACTTCAATAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017689_2

>merge|NZ_CP017689|2|1171996-1172097|CRISPRCasFinder
GCCACGTCCGCAATTTGATTTTTATTACTTCAATAACACAAGCGCGTCTACCGCTAATACCCATGCCACGTCCGCAATTTGATTTTTATCACTTCAATAACA

>NZ_CP017689|2|2|1171996-1172097|CRISPRCasFinder
GCCACGTCCGCAATTTGATTTTTATTACTTCAATAACA	CAAGCGCGTCTACCGCTAATACCCAT
GCCACGTCCGCAATTTGATTTTTATCACTTCAATAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017689.1\|WP_082897204.1\|1186356_1189032_+\|carbohydate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|119337
NZ_CP017689.1\|WP_068546893.1\|1185192_1185903_+\|SapC-family-protein	unknown	unknown	gnl\|CDD\|377801
NZ_CP017689.1\|WP_068546895.1\|1181101_1181794_-\|aquaporin-Z	unknown	unknown	gnl\|CDD\|235453
NZ_CP017689.1\|WP_068546902.1\|1168381_1169179_-\|collagen-like-protein	unknown	unknown	gnl\|CDD\|189968
NZ_CP017689.1\|WP_068546906.1\|1162196_1162655_-\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|234575
NZ_CP017689.1\|WP_068546936.1\|1163734_1165177_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237673
NZ_CP017689.1\|WP_068546905.1\|1162654_1163671_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224616
NZ_CP017689.1\|WP_068546892.1\|1185951_1186242_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017689.1\|WP_068546901.1\|1169653_1171483_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|227903
NZ_CP017689.1\|WP_068546890.1\|1189289_1190177_+\|ATPase	unknown	unknown	gnl\|CDD\|225518
NZ_CP017689.1\|WP_068546903.1\|1167295_1168099_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|131480
NZ_CP017689.1\|WP_068546904.1\|1165438_1165735_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017689.1\|WP_068546908.1\|1159664_1161206_-\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP017689.1\|WP_068546894.1\|1182385_1185052_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|273804
NZ_CP017689.1\|WP_068546907.1\|1161283_1162165_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226910
NZ_CP017689.1\|WP_068546935.1\|1166109_1167276_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|181199
NZ_CP017689.1\|WP_068546896.1\|1179334_1180978_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234679
NZ_CP017689.1\|WP_068546899.1\|1176093_1177266_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP017689.1\|WP_068546897.1\|1178094_1179111_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380487
NZ_CP017689.1\|WP_068546900.1\|1173000_1176078_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911

Protein	Function_ID	Function_description	E-value
NZ_CP017689.1\|WP_082897204.1\|1186356_1189032_+\|carbohydate-binding-domain-containing-protein	gnl\|CDD\|119337	cd06569, GH20_Sm-chitobiase-like, The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	0
NZ_CP017689.1\|WP_068546893.1\|1185192_1185903_+\|SapC-family-protein	gnl\|CDD\|377801	pfam07277, SapC, SapC. This family contains a number of bacterial SapC proteins approximately 250 residues long. In Campylobacter fetus, SapC forms part of a paracrystalline surface layer (S-layer) that confers serum resistance.	2.35818e-83
NZ_CP017689.1\|WP_068546895.1\|1181101_1181794_-\|aquaporin-Z	gnl\|CDD\|235453	PRK05420, PRK05420, aquaporin Z; Provisional.	3.15773e-136
NZ_CP017689.1\|WP_068546902.1\|1168381_1169179_-\|collagen-like-protein	gnl\|CDD\|189968	pfam01391, Collagen, Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.	6.05416e-05
NZ_CP017689.1\|WP_068546906.1\|1162196_1162655_-\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	3.18987e-56
NZ_CP017689.1\|WP_068546936.1\|1163734_1165177_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237673	PRK14325, PRK14325, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NZ_CP017689.1\|WP_068546905.1\|1162654_1163671_-\|PhoH-family-protein	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	6.45991e-162
NZ_CP017689.1\|WP_068546900.1\|1173000_1176078_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP017689.1\|WP_068546901.1\|1169653_1171483_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|227903	COG5616, COG5616, Predicted integral membrane protein [Function unknown].	7.61777e-47
NZ_CP017689.1\|WP_068546890.1\|1189289_1190177_+\|ATPase	gnl\|CDD\|225518	COG2971, COG2971, Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism].	3.18277e-67
NZ_CP017689.1\|WP_068546903.1\|1167295_1168099_+\|alpha/beta-hydrolase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	8.86248e-24
NZ_CP017689.1\|WP_068546908.1\|1159664_1161206_-\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	5.71068e-180
NZ_CP017689.1\|WP_068546894.1\|1182385_1185052_+\|TonB-dependent-receptor	gnl\|CDD\|273804	TIGR01782, TonB-dependent_receptor, TonB-dependent receptor. This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins].	0
NZ_CP017689.1\|WP_068546907.1\|1161283_1162165_-\|CBS-domain-containing-protein	gnl\|CDD\|226910	COG4535, CorC, Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism].	1.25164e-129
NZ_CP017689.1\|WP_068546935.1\|1166109_1167276_+\|FAD-dependent-monooxygenase	gnl\|CDD\|181199	PRK08020, ubiF, 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed.	4.48081e-172
NZ_CP017689.1\|WP_068546896.1\|1179334_1180978_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NZ_CP017689.1\|WP_068546897.1\|1178094_1179111_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380487	cd01545, PBP1_SalR, ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators. The SalR binds to glucose based compound Salicin which is chemically related to aspirin. The ligand-binding of SalR is structurally homologous to the periplasmic sugar-binding domain of ABC-transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	3.96452e-115
NZ_CP017689.1\|WP_068546899.1\|1176093_1177266_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	1.42222e-25

>NZ_CP017689.1|WP_068546901.1|1169653_1171483_+|tetratricopeptide-repeat-protein
MSASLFEELKRRNVFRVGVSYLVLAWIVIQVTSIAVPALHLPDWVNSLVFYFGLIGFPFALFFAWAFEITPDGIKREADVDRSQSIAPQTGRYLDYTIIALLSVALLYFVWESRFETDTLTQPEVAAEHTPASISKVISIAVLAFENMSSDKEQSFFSDGISEEILNVLVKVPGLDVSSRTSSFQFKGRDIGIPAIAKELKVRYVVEGSVRKAGDNIRVTAQLIDSTNDKHLWSDTYDRPLNIENVFVIQDEIAGSIVQALSDVLGTNQIAVKVDKSTNNLDAYELYLKARTLFHARIDLDIADQLLVQAIDKDANFSKAWGIRSALQSLMVEYGYSDNSIDNVDRLTVEYAKTAIGLNPNSATAFAAMGLMMYNSNVDLRTQYNWEEIFELYEKALSIEPTSASALNWQGLSYLSVGELDEALKSFKQCIEYEPYYTPCVDNQMVMLGYMGTDDEAVKAFLDALDSGLVKLDQASYFLPLLARLNKELVFKSVTNLQTVLFGWRRHDELYDAYRNPGEIYTELITDIKRFSESNRVSEPTYLRMILLYIGDYDALPFTLSMWDKSLYNYRQSPQFHSFIKKSNVLKYWQNNGFPKQCKPQGKVDFYCD
>NZ_CP017689.1|WP_068546902.1|1168381_1169179_-|collagen-like-protein
MKSKILTILITSFTLFACDGDNGSTGTAGASGEQGPQGVMGEQGVQGESGINCWDLNLNRVNEADEDVNKDGAWNAFDCTANVTSSQTSEVMYSHQQFCEAFANLGQYPEGCPSDTHTMPTGTITEMNSAQFFEDEMGNYNSCSASPEDGLLTIKHRESTNADGTPSRQAWFEVKGAYIAKEQIVSIFDEINSSACKTICENDSKCVAANASKSTDEAFSCRIFYHSDTVDKYEKICGVDTDFANAAELCILSLGGSQRWASMCQ
>NZ_CP017689.1|WP_068546903.1|1167295_1168099_+|alpha/beta-hydrolase
MTTSLLYHKTYLQSKSKEWIVLVHGAGGSSSIWFKQIKEFKKHFNLLLIDLRGHGRSASFTAKASNRRGYSFNDVSLDIIQILDHLSITKAHFVGISLGTILIHKLAEIAPSRVDVMILGGAITRFDVRSLALVKLGNLFKDVIPYMWLYRLFAYILMPQKGQVEARSLFIKDAKKLCQKEFKRWFKLANGVNPLMQHYKKNELTKPVLYLMGANDYMFITPVIDMVTHHENSKLIKIQDCGHVCNVEKPAEFNKHAIDFIHHHAGD
>NZ_CP017689.1|WP_068546935.1|1166109_1167276_+|FAD-dependent-monooxygenase
MKSFDCVIVGGGMVGGATALALSDLGLSVAIVEAHTPKSFDREQDFDLRVSAISVASEQLLEQLQAWQQISEWRTCPYKRLGVFEDDIAYAEFNSDEIGQSHLGHIIENRLIQLSIWQQIETRANIHLYCPQTLVGFEQTAESITVELNNENITSKLLIGADGANSKVRQLANIGTTGWDYKQSAMLINVETQLPQQDITWQQFINGAPVAFLPMPGNNGSLVWYDSRDEINRLVKLTNEQLQDEIAAHFPVKLGSIVVKDKGAFPLTRRHANQYVENRVVLLGDSAHTINPLAGQGVNLGFKDVAALQSVIAKAIGDGENFDDAKVLQRYQQKRKPDNLVMQGAMDAIYATFNNPSTPIKLLRNIGMFAAHRVPLLKQKALKYACGL
>NZ_CP017689.1|WP_068546904.1|1165438_1165735_-|hypothetical-protein
MNILTKSLIAISLVSSSTFALANTADPQMPVFEVTYVENVDVVKQQTRHLLQQMDYKLTLDISRQARNSIETEILNLAQESNLYAISAKAQTTKLYSE
>NZ_CP017689.1|WP_068546936.1|1163734_1165177_-|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MSKKLYIKTWGCQMNEYDSQKMADLLDSTHGFIEVKEPEEADVLLLNTCSIREKAQEKVFHQLGRWKNMKNDNPELIIGVGGCVASQEGDAIRQRAPFVDIVFGPQTLHRLPEMINQVNGEHTSVVDVSFPEIEKFDRLPEPKAEGPTAFVSIMEGCSKYCTFCVVPYTRGEEVSRPLDDVLYEIAQLAEQGVREVNLLGQNVNAYRGDTHDGDICRFSDLLRLVATIDGIDRIRYTTSHPVEFTNDIIEAYNDIPELVDHLHLPVQSGSDRILNMMKRNHTAIEYKSKIRALKKVRPELCMSSDFIIGYPGETDADFEATMNLIKAIDFDLSFSFIYSARPGTPAADAIDDVSEETKKQRLQILQDRITQQALSIARRMLGTEQRILVEGPSKKNPMELRGRTENNRIVNFEAPHTVIGQFVDVEITDVYSNSLRGKLVRTEDEMGLRIAHSPADILANQHHGKPNYETDDLGVATFTP
>NZ_CP017689.1|WP_068546905.1|1162654_1163671_-|PhoH-family-protein
MSKDNQSHEVLLEPLDNNRLANLCGPLDDNLRKIERRLGVEIGYRGNKFKIHGKEQVCVAVVKLLKDLYVQTAPVKGKVGTVSAEELHLALTELNMLEQETAETAAEFDQMVTIRTKRGVIKPRNENQGEYVQNVLTNDISFGVGVAGTGKTYLAVACAVDALERQEVRRILLTRPAVEAGEKLGFLPGDLSQKVDPYLRPLYDALFEMLGFEKVEKLIERNVIEVAPLAYMRGRTLNDAFIILDESQNTTVEQMKMFLTRIGFNSKAVVTGDITQVDLPRGQRSGLRHAIEVLTDIKGVSFNYFQSKDVVRHPVVGRIVEAYERHESVNTPNAEYKR
>NZ_CP017689.1|WP_068546906.1|1162196_1162655_-|rRNA-maturation-RNase-YbeY
MATITLDIQRPYQTENLPSDEQFQQWADIALLPYNKDFELTIRVVNNDESQQLNKQYRDKDKPTNVLSFPFEVPDGIELDLLGDLVVAADVVSTEAIDQNKQIHAHWAHMIIHGCLHLLGYDHITQDEAEEMEAIEIRLMAELGHNNPYIAS
>NZ_CP017689.1|WP_068546907.1|1161283_1162165_-|CBS-domain-containing-protein
MSDDNPHSGNGSSKTLMEKIVQVFTGEPKNKEELVEVLNDAQDRDLIKPATKQMLEGVLEVSDMRVRDIMIPRSHMVTIDIEQSVSEFLPTVLESAHSRFPVINDDIDHIEGVLLAKDLLAYGFNADAAEVSLKDIIRPAIIIPESKKVEPLLKEFRQQRYHMAVVVDEYGGVSGLVTIEDILELIVGEIEDEHDDMLEREIRHLSGNVYQVKALTEIDNFNEYFNAGFNEEEADTIGGIVIHQFGHMPNRGESINILGFEFKVVSADKRRIQQLQVAVPKDHEVNGKLADDR
>NZ_CP017689.1|WP_068546908.1|1159664_1161206_-|apolipoprotein-N-acyltransferase
MNNKTSLLSIEHSLWKRYVPNFLLGAIMVFSYAPFSLWFVSIAALSIWIYLLNEQDKKQAFRSAFAFGLGFFGVGISWVHVSIEQFGGLPLIVSILLMVLLCAYLALFTGLAAYLAARFNQNKVSLVYLPFTWLIAETLRGVVLTGFSWLSIGYSQIDGPFAALAPIIGEIGISFIVILIACLLVSIVNKQRLKLNSAILASVVIVTIIASQLSFVEKTGKVINTALVQGNIKQELRWDKQAEQNIIDLYIDQTTELYKNNDLIIWPEAAIPRLEPLSQDILSKLNHEAAQANTALITGIINYEPDSSAFFNRLIVLGNKNVDDNEGDYYWRNSNHYDKHHLLPIGEFIPFQELLRPIAPLFNLPMSSFSRGDYVQKNLIANGIQIAPLICFEVVFSKQLAANFDNDTEILLTVSNDAWFGASHGPDQHLEIARMRALEYARPMLRATNNGLTAVIDHNGRISADIEQFTLSTLQTKVDVVTGTTFYSDYGIHLDKLLFVVFALMLIIRRYRN
>NZ_CP017689.1|WP_068546900.1|1173000_1176078_-|efflux-RND-transporter-permease-subunit
MIELFVKNGRLMVLMIAIIIVAGLASLSVLPRAEDPTMVNRAASVITPFPGASAERVEALVTEKIEQKLRRLAEIDYLESTSRPGISVIQVKLKGEVSDSDPVFSRIRDLLNDVDHELPQSAMSPILEDERSFAYTQLVAVKWADDSPVNQIILGRYATELKSQLRLVSNTDIVEIHGQNDEEILVELNQQLAAQSSISLQQVSNAIARADVKVPAGKLVNDYNQMQIELTGALISLDRIRNIPIYSDSNSSLLVGDVANIKRQIISPHDEAAIINGRPAIVVGTRMLTGVRIDQWSIKVAEKIAEFEQSLPENIELEVLFDQNTYTSVRLSDLVNNIFIGFGIIAAVLLVSLGFRSALIVVASLPLTVFFTLSVMNFYGLPIHQMSVTGLVVALGIMVDNAIVMTDTIQQKKMKGIRGLQAVLESVKHLWMPLMGSTLTTVLAFMPIVLMPGDAGEFVGGIALSVIFALIGSYIISHTIVAGLSGRFIKIDNSKTGWLYQGITLPKLHVLFEKSLAKSLHKPKLTIAIVLLLPIAGFFSASQLHEQFFPASDRDMFQIELYMPAQTSINATTTMTQQISEYLNQYNEIKALNWFIGKSAPSFYYNLMSSKDGMQNYAQAMVSAADFEVANKLIPQLQFDLDNHFPEAQILVRKLEQGPPFNAPIEIRLFGPNLDILQSKGNEIRKVFSETDHIIHSRATLMPGTPKVWLEADEETVNRLGLNLADIANQLNLALDGSKQGSVIEATESINVRVKIADSEHQSINDLANFPIVNNKDGSSFPLSAVSKSVVSPSRGAIPHRDGMRVNVIEGYVRTGVLPSMVLAEIQQKLEQQDFNLPNGYSIQIGGESGARDEAVGKLMSSVGIIAILLITVVVLSFNSFRISSIIFISGFMSTGLGLLSVYMFNHPFGFTVIIGLLGLMGLAINSAIVILAELKADSKAISGDNNAIIHAVLSCTRHISSTTITTVGGFLPLILAGGGFWPPFAIAIAGGTVLTTLLSFYFVPAIFCLMSKSKPFEQTNTVMA
>NZ_CP017689.1|WP_068546899.1|1176093_1177266_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MIFKLNNFPLSNRKTSFIVTFIFLAVLLLIAGCGEDPTKSSSKIIDSSQPFYHQVQSEALVKQSSYLVNRKFAGTVVSKQTASLNFEIQGRVDQVLVDEGAKVEQGQLLAQLDSELLSIELKQLKAQLMQVSADMDLVKANLTRNNSLLEQGYTSAQRLDELNAQQNVLLANEQQLNASIEAKQYQINHSQIRAPFAGTVNKRMINNGEVVNQQIIAFEIQRRGNNELKVGVPKSLIPYVKDQKQYHLSINEQDYIVDNLAINSNINLQSRTVQLRFELVDNIEVFNNQIAYFKFQQEHQEQGFWVPLAALTDGIRGTWNIYILKPLENDPELFEIKSHSIVLLHSEQDKAFIQVDLPSGTEILKSGIQRFVPGQKVRKSKTVINTALAH
>NZ_CP017689.1|WP_068546897.1|1178094_1179111_-|LacI-family-DNA-binding-transcriptional-regulator
MKVTINDVAKLSGVSIKTVSRVINKEASVRQATREKVLAAVSELNYQPNLAARSLAGTSSYTIAYIYDNPNAYYIIDMQNGILNECRKQDFELVIHPCNSKSGDIVDEISNMIRHSRIAGVVLTPPFSEMEDVIQKLHDMGVKFVRIFSGNKSKDNLSSCIMVNDFDASYELTKHLIELKHKDIGFICGGKEHKSTDERLNGYKAALTDHDIAINNDYIVDGEYSFESGVKGSEALLQLKNKPTAIFGCNDEIAAGALFGSRLQNIKIPDQLAVVGFENSPFSRQTWPQITTADQPNQTIAENATSMLISDIRGTNKELVCEQFVPKLVVRGSSNKEE
>NZ_CP017689.1|WP_068546896.1|1179334_1180978_+|glucose-6-phosphate-isomerase
MTSRTQLNSWKKLQSLAEDIKSTHLNQLFEQNPDRFDNFSLKLDNMLFDYSKNLINQEILDTLIELANDVQLSHWREKMFNAERINLTENRAVLHTALRNRSLSPIMLDGENVTEQVEAQLEKMKGFVQQVRQGSWLGYSNKRITDIVNIGVGGSNLGPQMVTEALKHESDQSVNVHYVSNVDGTQISEVLAPLNPEKVLFIISSKTFTTTETITNANTAVAWLLNKSQDKASIAKHFVAVTANKENAMKFGIDGDSIFSMWDWVGGRFSLWSAIGLPIALDIGFEKFIQLLEGAHEMDEHFKHAPFDQNAPVLLALISLFNCTFLGFKSQAILPYDQSLHMLSAYLQQAEMESNGKSVNWHGEQVPYATVASIWGELGINGQHAFYQYLHQSNNVVPADFIGSIEPVSGLKHHHTTLMANFFAQTQALMTGVNEQQVRQDLKAKGRVQQVIDKIAPHKVHEGNRPTNTLLMSKITPHTIGQLIALYEHKIFSQGILLQICSFDQWGVELGKGLAANIEDELNSDSSCADHDGSTANLIKHYKALAS
>NZ_CP017689.1|WP_068546895.1|1181101_1181794_-|aquaporin-Z
MTLTNKLAAEFFGTFWLVLGGCGSAVLAANVDLGIGYVGVSLAFGLTVMTMAYAIGHVSGCHLNPAVSFGLWSGGRFPANELLPYIGAQVIGGIAGAAVLYSIASGAPGFDVAGGFASNGYGAHSPESYSMVAVLIAEVVMTFMFLMVILGATDKRAPAGFAPIAIGLCLTLIHLITIPVSNTSVNPARSTGVAVFVGDWATAQLWLFWVAPIVGALLAGKVYSWVSAEK
>NZ_CP017689.1|WP_068546894.1|1182385_1185052_+|TonB-dependent-receptor
MSSFKFQKNILATTVAMVITGASAPVLAAEEAASDVEVIEVRGIRGSMKENINAKRFSDSVVDVITSEDIGKFPDKNVAESLSRITGVGVSREYGEGEKITIRGAGPTKNRTLLNGQNVATADWFILDNPSRGFNFTLLPSSLVKGLEVYKTPEASIDEGSIGGTVVMNTRKPLELDANHISIGLQGQYSETSEETDPQIDALYSWKNEAENFGVLVSVTKQDRTVQREGVEVLGWTPADANGMKAPKDIGNPIFIQDRERETIFASIQYAPSDNLDFTLNILDSSMDANNANVNLLIRPQNNLDTLVNTKSNGNNIYAGEVTAAGSYEWDFINRESSTETSSYDLEMNYSGDGYSIHAQVGTTEAEGGTYNEASWSFVPNVDDANKTYAFDLSGTPSIDIGVDPLDGSQWGQNWTWGGNKPTTDEETYAQLDLTFDVDYGAFYEIKTGIKYRDHDRSQGRQAYSWHGPETLPEGVEGNYMEWIFEQCPTLADCGQSTGSHKVADDVVNGNVVEQLKGSRSQFMTLAFDGYGDVPADYAVSNVLSEIWDINESILALYAQGNFSGDGFRGNLGIRVVQTEQESSSYNFSQDSWGFHTVDREWLTPTYMEWVTEDRDYTEILPSFNIAFDVTEDQIVRFGAARVMARPNFSDLAPIETTGALNVEFPTGTAGNPNLDPQIADQFDMAWEWYFDESALLSVTYFYKDIQSYRTSGTTVKPFYDQENDQLVDVTLTRPDNGLGGSTDGIELGYQQAFGNFGLSANYTYTNADTDQTRDEMVAGSGLVEGASEHMYNVTAYYENDTFGARLMYNFRTEWYKGLHFSGDEVWNDEYGQLDFSSSYKLTENVSLSFEAVNISDEEVIEYNTDPARLMSVYQNGRRFVAGVNLTF
>NZ_CP017689.1|WP_068546893.1|1185192_1185903_+|SapC-family-protein
MSQQNIQPLNKNIHGKIKIKQQSNFAHIKGQHLAPVVVHEFSRAGSEFPVCFVKNSDSGSFQPVALFGVKPGENAYTETERWEGTYVPAVVTHFPLALVADGKEEDKFMVVIATENEVVNEEDGAALFDDNGDETEFLARRKEALGKYLEHTHMTKMFTEVLVEKDLLVQQNLEITVKEEKIQINGLYLVDEKKLNELSDEDYLDLRKRGLIGPIYAHLNSMHQINRLVTKKAALS
>NZ_CP017689.1|WP_068546892.1|1185951_1186242_+|hypothetical-protein
MKNHIVKSITIVDGSSSRWVSALYLIKLYSHASIQIQTSVIESKYIIDRIKHKLNETVKAVAFFNQLDQHSKSLVTQLPEHRALIEKVKKYGLSKV
>NZ_CP017689.1|WP_082897204.1|1186356_1189032_+|carbohydate-binding-domain-containing-protein
MGIENVKKSFALTLATSLIISACFDNKTPQPGTSIDSQQSIISQESLNQFADSVDVKYQLVTNIPTEQCDENRGDGNCFVVEMSFTAKQDFYGKGWAIYFSQINPVQSVDSDIFTIEHVNGDLHKITATDKFTGFKAGQKYSMQYRVDFWSLSETDALPNYIVHAPELDAQVIKSTQTVINPETGLEKYPFVENYTSVEKQFNRTATEQTKWATAELLFERNAAKEMATKNIKEQLIPTPKSIKVSSGTIDLSKGISIEFNADKAPLNSALQRLETLGIKQSKNGVNVSLAIEKSNNVLGSYQLVSGDTGIAISANDISGLYYGLQSIAALVAVDDLSIPFVHIDDEPHYQFRGMMVDVARNFHSKQFVLDLLDQMAAYKLNKLHLHLGDDEGWRLEIDGLPELTDISSKRCFDLSEQTCLLPQLGAGVDSSSSVNGYYSKQDYIDILKYASERHIQVIPSLDMPGHSRSSIVAMKARYKRLMAAGDEQGAKQYLLHDENDTTVYSSVQYYNDNTINGCMESSYDFIGKVMDEVKSLHEQAGQPLSRYHIGADETAGAWVESPICKAFIANNDAGVTKPEQVGSYFIERVAKILTERGIETAGWNDGMMHTNPENMPDVVQANSWGLTYWQGHQAAHKLANQNWEIVVSSPDATYFDFPYEADPKEHGYYWASRHSNTEKLFQFMPDNLPVHAEFWLDREDKPYQTDDSLVIGDKGEISSAPMKVGKKFVGIQGQLWSENTRNDDLAEYKIFPRLFALAERAWHLPNWSVPYPYKGKKYSQETSNFTDEKRQQRDQNWAEFANVITNKELNKLDRANIFYRIPTVGGKIIDGKLYINSTLPGLALEYKTAESKWTSWTQPVTVTTDVLVRARSKDLTRAGRELEVKFVAIK
>NZ_CP017689.1|WP_068546890.1|1189289_1190177_+|ATPase
MMESNNNQLYLGIDGGGSKCKAIIMNADMQVLGEGISGAANPFHNLERAQRSVENAAELALENAGLDIATKKSLIAGVGLAGVNLPKYFALMNAWQHPFKSMHLATDLHIACLGAHGGNDGAIMITGTGSCGYVTVNGEQLIIGGHGFPHGDICSGAWLGFKAVEHVLLSLDGVIEPTVLTNKILTLLDCHDASTLIETIAGNNATYYAKLAISVFDAADNGDAVAIDIINQGCQYFSAVYKKLKAKGDVPLSLIGGLKPRLMEWLNSDIAKQIQEPQNPPEVGAVLFARQQSGL

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Crispr_ID: NZ_CP017689_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017689_3

1405802-1405892

Orphan

Consensus_repeat	Method
AATACTAAATGAGGTTCAGTTAATGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017689_3

>merge|NZ_CP017689|3|1405802-1405892|CRISPRCasFinder
AATACTAAATGAGGTTCAGTTAATGGAGCAATGACTACCGAAACTATTACATAGAGAGGCGTCGAATACTAAATGAGGTTCAGTTAATGGA

>NZ_CP017689|3|3|1405802-1405892|CRISPRCasFinder
AATACTAAATGAGGTTCAGTTAATGGA	GCAATGACTACCGAAACTATTACATAGAGAGGCGTCG
AATACTAAATGAGGTTCAGTTAATGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017689.1\|WP_068545067.1\|1407528_1407951_+\|protein-TolR	unknown	unknown	gnl\|CDD\|274306
NZ_CP017689.1\|WP_068545073.1\|1415220_1416276_+\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NZ_CP017689.1\|WP_068546610.1\|1397194_1397929_-\|carboxy-S-adenosyl-L-methionine-synthase-CmoA	unknown	unknown	gnl\|CDD\|273244
NZ_CP017689.1\|WP_068546608.1\|1395460_1396045_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017689.1\|WP_070795903.1\|1401044_1402232_+\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NZ_CP017689.1\|WP_068545069.1\|1410386_1410938_+\|peptidoglycan-associated-lipoprotein-Pal	unknown	unknown	gnl\|CDD\|182744
NZ_CP017689.1\|WP_068545064.1\|1404645_1405629_-\|XdhC-family-protein	unknown	unknown	gnl\|CDD\|224886
NZ_CP017689.1\|WP_068546611.1\|1398353_1400135_+\|aspartate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234775
NZ_CP017689.1\|WP_068545063.1\|1404081_1404645_-\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|133025
NZ_CP017689.1\|WP_068545333.1\|1408002_1408959_+\|cell-envelope-integrity-protein-TolA	unknown	unknown	gnl\|CDD\|368950
NZ_CP017689.1\|WP_068545061.1\|1402363_1402990_+\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NZ_CP017689.1\|WP_068545065.1\|1406421_1406838_+\|tol-pal-system-associated-acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|274304
NZ_CP017689.1\|WP_068545066.1\|1406827_1407520_+\|protein-TolQ	unknown	unknown	gnl\|CDD\|131843
NZ_CP017689.1\|WP_068545071.1\|1412992_1413859_-\|glutathione-dependent-disulfide-bond-oxidoreductase	unknown	unknown	gnl\|CDD\|183298
NZ_CP017689.1\|WP_068546609.1\|1396220_1397186_-\|tRNA-5-methoxyuridine(34)/uridine-5-oxyacetic-acid(34)-synthase-CmoB	unknown	unknown	gnl\|CDD\|237898
NZ_CP017689.1\|WP_068545068.1\|1408979_1410335_+\|Tol-Pal-system-protein-TolB	unknown	unknown	gnl\|CDD\|235312
NZ_CP017689.1\|WP_068546612.1\|1400317_1400845_+\|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl\|CDD\|234587
NZ_CP017689.1\|WP_068545062.1\|1403015_1404023_+\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NZ_CP017689.1\|WP_068545070.1\|1410981_1411740_+\|tol-pal-system-protein-YbgF	unknown	unknown	gnl\|CDD\|224643
NZ_CP017689.1\|WP_068545072.1\|1414209_1415145_+\|MASE1-domain-containing-protein	unknown	unknown	gnl\|CDD\|283013

Protein	Function_ID	Function_description	E-value
NZ_CP017689.1\|WP_068545067.1\|1407528_1407951_+\|protein-TolR	gnl\|CDD\|274306	TIGR02801, Protein_TolR, TolR protein. The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	3.91355e-52
NZ_CP017689.1\|WP_068545073.1\|1415220_1416276_+\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	0
NZ_CP017689.1\|WP_068546610.1\|1397194_1397929_-\|carboxy-S-adenosyl-L-methionine-synthase-CmoA	gnl\|CDD\|273244	TIGR00740, tRNA_cmo5U34-methyltransferase, tRNA (cmo5U34)-methyltransferase. This tRNA methyltransferase is involved, together with cmoB, in preparing the uridine-5-oxyacetic acid (cmo5U) at position 34. [Unknown function, Enzymes of unknown specificity].	7.27751e-105
NZ_CP017689.1\|WP_070795903.1\|1401044_1402232_+\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	1.23573e-06
NZ_CP017689.1\|WP_068545069.1\|1410386_1410938_+\|peptidoglycan-associated-lipoprotein-Pal	gnl\|CDD\|182744	PRK10802, PRK10802, peptidoglycan-associated lipoprotein Pal.	3.07988e-54
NZ_CP017689.1\|WP_068545064.1\|1404645_1405629_-\|XdhC-family-protein	gnl\|CDD\|224886	COG1975, XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones].	2.86102e-46
NZ_CP017689.1\|WP_068546611.1\|1398353_1400135_+\|aspartate--tRNA-ligase	gnl\|CDD\|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP017689.1\|WP_068545063.1\|1404081_1404645_-\|nucleotidyltransferase-family-protein	gnl\|CDD\|133025	cd04182, GT_2_like_f, GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	7.22943e-42
NZ_CP017689.1\|WP_068545333.1\|1408002_1408959_+\|cell-envelope-integrity-protein-TolA	gnl\|CDD\|368950	pfam06519, TolA, TolA C-terminal. This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.	1.55117e-26
NZ_CP017689.1\|WP_068545061.1\|1402363_1402990_+\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	6.56384e-99
NZ_CP017689.1\|WP_068545065.1\|1406421_1406838_+\|tol-pal-system-associated-acyl-CoA-thioesterase	gnl\|CDD\|274304	TIGR02799, Acyl-CoA_thioesterase_YbgC, tol-pal system-associated acyl-CoA thioesterase. The tol-pal system consists of five critical genes. Inner membrane proteins TolQ and TolR convert protomotive force to energy that is transduced through TolA to an outer membrane complex of TolB and Pal. The system is known to be required to maintain outer membrane integrity. In a system with several homologous parts, ExbB and ExbD transduces energy through TonB to a variety of outer membrane proteins, many of which are siderophore receptors. The tol-pal system therefore may also be involved in transport. This family consists of a protein nearly always found in operons with the genes of the tol-pal system. The significance of this thioesterase to the tol-pal system is unclear, but either of two observations may be relevant. First, Pal, or peptidoglycan-associated lipoprotein, has a conserved N-terminal cleavage and acylation that makes it a lipoprotein. Second, the tol-pal system is implicated not only in the import of certain organics but also in the maintenance of outer membrane integrity (by an unknown mechanism).	4.49402e-57
NZ_CP017689.1\|WP_068546609.1\|1396220_1397186_-\|tRNA-5-methoxyuridine(34)/uridine-5-oxyacetic-acid(34)-synthase-CmoB	gnl\|CDD\|237898	PRK15068, PRK15068, tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB.	0
NZ_CP017689.1\|WP_068545071.1\|1412992_1413859_-\|glutathione-dependent-disulfide-bond-oxidoreductase	gnl\|CDD\|183298	PRK11752, PRK11752, putative S-transferase; Provisional.	0
NZ_CP017689.1\|WP_068545066.1\|1406827_1407520_+\|protein-TolQ	gnl\|CDD\|131843	TIGR02796, Protein_TolQ, TolQ protein. TolQ is one of the essential components of the Tol-Pal system. Together with TolR, it harnesses protonmotive force to energize TolA, which spans the periplasm to reach the complex of TolB and Pal at the outer member. The tol-pal system proves to be important for maintaining outer membrane integrity. Gene pairs similar to the TolQ and TolR gene pair often number several per genome, but this model describes specificially TolQ per se, as found in tol-pal operons. A close homolog, excluded from this model, is ExbB of the ExbB/ExbD/TonB protein complex, which powers transport of siderophores and vitamin B12 across the bacterial outer membrane. The Tol-Pal system is exploited by colicin and filamentous phage DNA to enter the cell. It is also implicated in pathogenesis in several bacterial species [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	2.18202e-110
NZ_CP017689.1\|WP_068545068.1\|1408979_1410335_+\|Tol-Pal-system-protein-TolB	gnl\|CDD\|235312	PRK04792, tolB, Tol-Pal system protein TolB.	0
NZ_CP017689.1\|WP_068546612.1\|1400317_1400845_+\|crossover-junction-endodeoxyribonuclease-RuvC	gnl\|CDD\|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	8.05735e-91
NZ_CP017689.1\|WP_068545062.1\|1403015_1404023_+\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NZ_CP017689.1\|WP_068545070.1\|1410981_1411740_+\|tol-pal-system-protein-YbgF	gnl\|CDD\|224643	COG1729, COG1729, Uncharacterized protein conserved in bacteria [Function unknown].	6.60775e-48
NZ_CP017689.1\|WP_068545072.1\|1414209_1415145_+\|MASE1-domain-containing-protein	gnl\|CDD\|283013	pfam05231, MASE1, MASE1. Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins. This entry also includes members of the 8 transmembrane UhpB type (8TMR-UT) domain family.	1.72369e-09

>NZ_CP017689.1|WP_068545064.1|1404645_1405629_-|XdhC-family-protein
MQLTDIPVFVAAKHLIAQNQHFWLCTILNTYGSAPRPIGSVFITDGEHRYGSISGGCLEDAFVEMLNQNKFKKHNQLFTYGDHATEQGVVRELPCGGTIELLIEYIEVNNSSTEHFLQCSNHAVNRLPFKRQMTLQSNTRECLELKDFAVKQVEKSADTVGLNYSKVFTLLLIGIGQVTEEIARLGLQAGFEVKVCDMRKQLASSWTFDKENGGVDIIWMSPDLFVEQYADEQSAVLALAHDPSIDDAALMSVFDTKAFYIGAMGSHRTTENRIERLTRICEIKQQQLSRLHAPIGLNIGSKTPFEIAISTLADIIRIKNHVSKEQL
>NZ_CP017689.1|WP_068545063.1|1404081_1404645_-|nucleotidyltransferase-family-protein
MNVALILAAGSSARYGADKRLSGNPPLIMQTISMVQKHFNHVYVLHRHIDPKLQSLLAPLELNLVAAPVDSQDMGDNIAHGVKTIESDIANVNNISVFLGDMPFMESSTIKSLLCLLASDNIVRPTFKGQQGHPVCFGNEFFDSLKTLNNVDGAKSVIQANLNRLNLLEVDDIGVIKDIDTKPDWHQ
>NZ_CP017689.1|WP_068545062.1|1403015_1404023_+|Holliday-junction-branch-migration-DNA-helicase-RuvB
MIEADRLIQPTITREEETVDRAIRPKMLDDYTGQDHVKEQMEIFIEAAKKRNEPLDHLLIFGPPGLGKTTLANIVANEMGVNIRTTSGPVLEKAGDLAALLTNLEENDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYKVGDLKDIIARSAHFLNVDLNDEGALEVAKRSRGTPRIANRLLRRVRDYAEVKSQGVVGQDTASKALNMLEVDNEGFDLMDRKLLLAIIDKFGGGPVGLDNVAAAIGEERETIEDVIEPFLIQQGFLQRTPRGRIVTDNAYLHFGLDKPSS
>NZ_CP017689.1|WP_068545061.1|1402363_1402990_+|Holliday-junction-branch-migration-protein-RuvA
MIGRLRGILVEKQAPEILIECNGIGYEVTLPMTSFYHLPQLEQETIIYTHFVVREDAQLLYGFANPTERKLFRLLIKVNGVGPKLALAILSNMSAGQFVHCVNLDDVATIVKIPGVGKKTAERLLIEMRDRLKDWGNDIATPMTDTISVDNQAEEAKFVIASSNKDDAITALVSLGYKPAQADKAVKAVYKQDLSSEELIRDALKSMV
>NZ_CP017689.1|WP_070795903.1|1401044_1402232_+|IS4-family-transposase
MNVDHILNQTLSFVTPKMHKVRRNSLKCLITSLIRGADLSVTNLGRNILSETSEKHQIKRSDRLCSNVHLHAEIPSIYETLTRKLVGTQKHPVILVDWSDLDARQENFLIRAAIAVNGRSLTLYEEVHPQSSKEKPKVHKDFMMVLKNMLPSTCRPIIVTDAGFRTPWFNMIQSLNWDYVGRMRNRTFCKQDKDWLPVKALYKLATTRPKSLGRFDVARCNPITCNFVIFKSRNKGRKDLVAKGNRRRRSGKSKANAKREREPWLLTTSLCSKQLGFAKKVVKIYTTRMQIEESFRDVKTGLNMNVCNSRKRLRILVLLVIALIAQYILMLIGMALVIQGKNRQYQANSVKSRAVLSYQFIALRAVRNLRFCIEKEEWKSAIKQLNKFMLEPLNV
>NZ_CP017689.1|WP_068546612.1|1400317_1400845_+|crossover-junction-endodeoxyribonuclease-RuvC
MSIILGIDPGSRLTGYGVIEKQGRKFSYLGSGCIKTLSAGDNHPERLQIIFAGVSELILQFKPDMFAIEQVFMGVNPGGALKLGQARGAAIVAATNNGIEVAEYSARQIKQAVVGTGAADKEQVQHMVTSFLKLPAPPQADAADALAVAICHAHSYDSLIKMSGQAKKTVRGRLR
>NZ_CP017689.1|WP_068546611.1|1398353_1400135_+|aspartate--tRNA-ligase
MRSVFCGEVNESHVGQEVTLCGWVNRRRDLGAVIFVDMRDREGIVQVVFDPDLPEVLAIANTLRNEFCIQVKGKVRARPESQVNKDMKTGAIEVLGLELTILNKAAPLPLDSNQENSEENRLKYRYLDLRRPEMTERLRFRSKVTSQVRESLESQGFMDIETPILTAATPEGARDYLVPSRTQKGNFFALPQSPQLFKQLLMMSGMERYYQIVKCFRDEDLRADRQPEFTQIDIETSFMTADQVMDVAETMIQELFKSLLNVDLGKFPHMTYEEAMTRFGSDKPDLRNPLEIVDIADIVKDVEFKVFSGPANDAKGRVSVIKVPGAAAGLSRKKLDDYTKYVGIYGAKGMPWLKVNDIDAGREGLQSPILKFLSDEAVAELLSRVNAASGDIIVFGADSYNVVTESLGALRLKLGEDLGLTTDEWKPLWVVDFPMFEEIEGGLHALHHPFTAPTKLTAEELEANPIGALSNAYDMVLNGCELGGGSVRIHDSEMQAAVFRILGISDEEAEEKFGFLLEALRYGTPPHAGLAFGLDRIVMLMTGATSIRDVMAFPKTTTAACPLTNAPGKANPAQLVELGIQAIPQEPSADEAE
>NZ_CP017689.1|WP_068546610.1|1397194_1397929_-|carboxy-S-adenosyl-L-methionine-synthase-CmoA
MSSQDKDLIYSSPQSVVNDFRFDAQVVEVFPDMIKRSVPGYSTIIETIGQLSARYAQDNTNIYDLGCSLGAASLAMRQNIVAENCNIIAIDNSKDMVERCQMHVNAFKATTPCEVKQGDILTENMQNASMIVLNFTLQFIAPEQRQTLLNNIANALVPGGILVLSEKIYDHDPVCRDLLNDLHHNFKRANGYSDLEIAQKRAAIENVMKPDELSTHIERLTQAGFNHATPWFQCFNFFSLIAIK
>NZ_CP017689.1|WP_068546609.1|1396220_1397186_-|tRNA-5-methoxyuridine(34)/uridine-5-oxyacetic-acid(34)-synthase-CmoB
MSFFNKFYQQIAANRLSHWLTCLPKQLSDWQQNELHGEYAKWQKTLDALPPLEPTDVDLINSVSVGANSGIPEGQQKRIENLLKNFKPWRKGPYQVHGVDIDTEWRSDFKWDRLLPHISDLNNRYVLDIGCGSGYHLWRMRGAGAKFVVGVDPTQLFMMQFRSIQHFIQDDNVNLLPLGVEHLPELKAFDTVFAMGVLYHRKSPIDFLQQLKAQLAPGGELILETLIIEGDENTVLVPGERYAKMRNVWFLPSGAALVHWMERLGFKNVRVVNTDQTAYEEQRKTDWIDTESLQDFLDPNDPNKTIEGYPAPLRAIVIANV
>NZ_CP017689.1|WP_068546608.1|1395460_1396045_-|hypothetical-protein
MLRIIALILPLLLMSYNANGIVRQRYPILPPNFDKISQGIMHSVCDRAMQGKNSGGFDGLMNDIRKYYGDPREFFYKYVMSLPCRSPSVSLADSILKKDFINTAFSNIFMKFGGVDPNSFVVIKREGLIFEGPLHVVYKHLEKHFKDSPNYGPEYRGVVMRLTVKRFVNGTPKSCKELQKEDPRMPCILPLPKK
>NZ_CP017689.1|WP_068545065.1|1406421_1406838_+|tol-pal-system-associated-acyl-CoA-thioesterase
MTNNNNAFTYQIRVYYEDTDAGGIMYYANYLKFAERARTEWLRSLNINQSFFLEQNLGFVVRKVEMDNKASAKLDDLLTITSTITNLKKASMVFEQTITNQQGVILCELSVLIASVNLQRGRPCAIPEQILGALDSAR
>NZ_CP017689.1|WP_068545066.1|1406827_1407520_+|protein-TolQ
MHAELSFFDLFLQASLLVKSVMLCLLGFSIASWTMIIQRSKALNSAQVNAQNFEDKFWSGADLSKLYKEISARGHADGLELLFVAGFKEFARIRKSSNASPQAVVDGTHRAMRVALSREVDTLETHLSFLATVGSISPYIGLFGTVWGIMNSFIALGAVEQATLAMVAPGIAEALIATAMGLFAAIPAVMAFNRFSHTVEKLENSYGNFMEEFSSILQRQSVASNQQQAQ
>NZ_CP017689.1|WP_068545067.1|1407528_1407951_+|protein-TolR
MYVRVKRKRVAEINVVPYIDVMLVLLIIFMVTAPLITQGVKVDLPKADSESLSQDSKTPLVASVDINGKFYLNVGDSKSEALAPDELATLVQARLQVEPDTPVVVNGDGNVSYNAIIQLMVLLQDAGVPSVGLMTESPEQ
>NZ_CP017689.1|WP_068545333.1|1408002_1408959_+|cell-envelope-integrity-protein-TolA
MSVFTYLPDGKTVKQEYIIAISAAVAVHIVMGIVLMLNTDFTPKPKPTPKPQMQVIDAVVIDQAKLNKQVEKLRKEKQAIADREAARIKELERRADDARKKRQKEADRIKKLEADRKKKEVEKKKADDAAKKAKALALKEENNRKKKVEERKKAEKAAADAKAKRIKEEKAAEERRRKKIEDEKKRKAEAERKKKEAAERAEQERLLEQQMLEEMASRNSARSQQVMSEVDKYSALIKQAIQRNFIDDPSYAGKHCQLKINLAASGFVIDVKSAGGDQFVCREAIKAVNKTGTLPVSEDPEVFKKLKNISLKYQSEYE
>NZ_CP017689.1|WP_068545068.1|1408979_1410335_+|Tol-Pal-system-protein-TolB
MFKKLSVSLVLFLAVVSKSHAELELVITGGVNTARPIAVLPFSYEGTTALPENVSKVISDDLLRSGKFNPLPAMDLPAMPTSLDNIDYQAWINTGVEAIVTGSIKETPDGRFLVSFKLIDVVRAQMTGGNSKALQNGKLVQSNDHILIDSKPTQYVPSNLLRTKAHQISDVVYEKLTGTKGAFLTKIAYVIVRDSGDKKYQLVMADYDGYNEQVLLRSSEPLMSPSWSPDARKLAYVTFEDRQAQIFIQDIYTAERELLSSFKGINGAPRWSPDGKKMAMVLSKDGNPEVYVMDIASKNITRITNHRAIDTEPNWSPDGNSLVFTSERGGKAQLYRVNLDNGRVRRLTYDGEMNLGGSFTPDGRHLIMVNRTQGQYHLAKQELDSMNPVQVLTKTRLDESPSIAPNGGMIIYSTLHGNRQVLGLVSVDGRFKARLPVKNGQVKAPSWSPYL
>NZ_CP017689.1|WP_068545069.1|1410386_1410938_+|peptidoglycan-associated-lipoprotein-Pal
MRLNKLVKSIAIALPLSVLAACSSNDTTDEDQAQIAANQAAAEEQAKQEQAAAEAAAAQKAAEMEAIKAEKEAQLAASSTVYFDFDTSALPADVAQILDLHAAFLTENSNARIVVEGHADERGTPEYNIALGERRAQAVQKYLENSGVMPSQIETVSYGEEKPAVSDRSEGAFAKNRRAVLVY
>NZ_CP017689.1|WP_068545070.1|1410981_1411740_+|tol-pal-system-protein-YbgF
MKSNNIVVGFALAVSAFSALAEEGAPVLDINQTTSVETNTVNPSNDVATLQRALQVRNRALNDMQQQINELQTEVSQLRGTTEEQAYTIQQILQRQRELYQDIERRLSAANTTPVATNSNESVNYSSNLSENQLYDRAVNLVLKERKYELAIAEFKSFNQKYPNSSYSANAHYWLGQLLFNKGDLSGAETEFSNVIDNYEDSTKRPDAMLKLGMVAQKQNNNAKAKSIYTKLISEYTGSSAAKLAETRLSSL
>NZ_CP017689.1|WP_068545071.1|1412992_1413859_-|glutathione-dependent-disulfide-bond-oxidoreductase
MTEKTYTPPKVWQWKKDNGGKFANINRPISGATHDTQLQSGNHPFQLYSLATPNGVKVTILFEELLALGIKEAEYDAYLIDIGEGDQFGEGFVNVNPNSKIPALIDRSGEKDIRIFESGAILMHLAEKFSQFIPSDPAEKAECLSWLFWQVGSGPYLGGGFGHFYAYAPEHFEYPIDRFTMEVKRQLDVLDKHLANNQFLCGDNYTIADMANWPWYGSLILGRLYDAAEFLQVDSYKHVTRWANEINEREAVIRGRMVNRNWGELTEQLHERHDSSDFENKTQDKLES
>NZ_CP017689.1|WP_068545072.1|1414209_1415145_+|MASE1-domain-containing-protein
MTQDFYNNKKSSKSILSIIVLSILYIIIAKVGMTLFSLKPTNITLFWLPAGLALIMYIKYKQVALPFIIVASFVANYSGMQLDNTASSIIHTTVASIIDGFAPYLGYVFMRFFKIDELDDYKSLSLFLCFVCILPSLVAGLLLTQNMVWGGYITSGEMFNMMINISFSDTVGMLLVYGIYSEMLSADQATNRSISENFNALIATSLLSLLLVWVAYEIFSLAILLIPVLLSVLAFKRLYVDLPLAQLAVICFILIMSILHMGPFESDNYYDSILLMMLFIFACNVCTNYMVIYCKVSDKKNNDKGNSIDIP
>NZ_CP017689.1|WP_068545073.1|1415220_1416276_+|quinolinate-synthase-NadA
MLETTLAVDFDYTFPAKPVPLNETEKADYKEKIKQLLIEKNAVLVAHYYTDPEIQALAEETGGCVADSLEMARFGREHPATTLIVAGVKFMGETAKVLTPEKTVLMPTLEATCSLDLGCPIEQFSNFCDQHPDRTVVVYANTSTEVKARADWIVTSSCALEIVEHLDDQGEKILWGPDKHLGAYIEKQTDADMIMWDGACIVHDEFKTKALSDMKALHPDAAILVHPESPLSVVALADAVGSTSQLIKAAQDMPHKKFIVATDRGIFYKMQQLCPDKEFFEAPTAGEGATCRSCAHCPWMAMNGLQAIHDSLIDGSGREIFVDMDVRDGALKSLGRMLDFSAELKKQQQGK

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Crispr_ID: NZ_CP017689_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017689_4

1894440-1894566

Orphan

Consensus_repeat	Method
GATTTAAAATCCCTCGTATTCTTTATACCGAGACGTGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017689_4

>merge|NZ_CP017689|4|1894440-1894566|CRISPRCasFinder
GATTTAAAATCCCTCGTATTCTTTATACCGAGACGTGGTTGTTCAAGTCCGGCCCCGGGTACCATTTTATGGTGTTCGCCTTAATCAGGATTTAAAATCCCTCGTACTCTTTATACCGAGACGTGGT

>NZ_CP017689|4|4|1894440-1894566|CRISPRCasFinder
GATTTAAAATCCCTCGTATTCTTTATACCGAGACGTGGT	TGTTCAAGTCCGGCCCCGGGTACCATTTTATGGTGTTCGCCTTAATCAG
GATTTAAAATCCCTCGTACTCTTTATACCGAGACGTGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017689.1\|WP_068546407.1\|1889965_1890610_+\|UvrY/SirA/GacA-family-response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|236538
NZ_CP017689.1\|WP_068546395.1\|1904498_1905191_+\|6-phosphogluconolactonase	unknown	unknown	gnl\|CDD\|238694
NZ_CP017689.1\|WP_068546399.1\|1899352_1900384_-\|ATP-dependent-6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP017689.1\|WP_068546405.1\|1892613_1893222_+\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|182763
NZ_CP017689.1\|WP_068546411.1\|1886971_1887784_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_CP017689.1\|WP_068546412.1\|1885059_1886823_+\|DUF3466-family-protein	unknown	unknown	gnl\|CDD\|378770
NZ_CP017689.1\|WP_162272306.1\|1896404_1897295_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|270700
NZ_CP017689.1\|WP_068546398.1\|1900452_1901886_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235619
NZ_CP017689.1\|WP_068546406.1\|1890615_1892475_+\|excinuclease-ABC-subunit-UvrC	unknown	unknown	gnl\|CDD\|234792
NZ_CP017689.1\|WP_068546404.1\|1895611_1895965_+\|purine-nucleoside-phosphoramidase	unknown	unknown	gnl\|CDD\|182648
NZ_CP017689.1\|WP_068546414.1\|1882920_1883166_+\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|368604
NZ_CP017689.1\|WP_068546396.1\|1903032_1904499_+\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|235579
NZ_CP017689.1\|WP_068546410.1\|1887937_1888885_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP017689.1\|WP_068546401.1\|1897422_1898493_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NZ_CP017689.1\|WP_068546400.1\|1898492_1899317_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|236956
NZ_CP017689.1\|WP_068546403.1\|1896048_1896315_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017689.1\|WP_068546413.1\|1883152_1885063_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236861
NZ_CP017689.1\|WP_068546397.1\|1901900_1902758_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|183082
NZ_CP017689.1\|WP_068546408.1\|1889675_1889939_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017689.1\|WP_068546409.1\|1888941_1889457_-\|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA	unknown	unknown	gnl\|CDD\|179953

Protein	Function_ID	Function_description	E-value
NZ_CP017689.1\|WP_068546407.1\|1889965_1890610_+\|UvrY/SirA/GacA-family-response-regulator-transcription-factor	gnl\|CDD\|236538	PRK09483, PRK09483, response regulator; Provisional.	1.35303e-134
NZ_CP017689.1\|WP_068546395.1\|1904498_1905191_+\|6-phosphogluconolactonase	gnl\|CDD\|238694	cd01400, 6PGL, 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.	2.24692e-73
NZ_CP017689.1\|WP_068546399.1\|1899352_1900384_-\|ATP-dependent-6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	1.7647e-126
NZ_CP017689.1\|WP_068546405.1\|1892613_1893222_+\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl\|CDD\|182763	PRK10832, PRK10832, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase.	7.77405e-57
NZ_CP017689.1\|WP_162272306.1\|1896404_1897295_+\|phosphotransferase	gnl\|CDD\|270700	cd05151, ChoK-like, Choline Kinase and similar proteins. This subfamily is composed of bacterial and eukaryotic choline kinases, as well as eukaryotic ethanolamine kinase. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. Bacterial ChoK is also referred to as licA protein. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	2.74281e-12
NZ_CP017689.1\|WP_068546412.1\|1885059_1886823_+\|DUF3466-family-protein	gnl\|CDD\|378770	pfam11949, DUF3466, Protein of unknown function (DUF3466). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 564 to 612 amino acids in length.	1.80661e-98
NZ_CP017689.1\|WP_068546398.1\|1900452_1901886_-\|pyruvate-kinase	gnl\|CDD\|235619	PRK05826, PRK05826, pyruvate kinase; Provisional.	0
NZ_CP017689.1\|WP_068546404.1\|1895611_1895965_+\|purine-nucleoside-phosphoramidase	gnl\|CDD\|182648	PRK10687, PRK10687, purine nucleoside phosphoramidase; Provisional.	1.80592e-67
NZ_CP017689.1\|WP_068546414.1\|1882920_1883166_+\|glutaredoxin-family-protein	gnl\|CDD\|368604	pfam05768, DUF836, Glutaredoxin-like domain (DUF836). These proteins are related to the pfam00462 family.	1.79454e-09
NZ_CP017689.1\|WP_068546396.1\|1903032_1904499_+\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0
NZ_CP017689.1\|WP_068546410.1\|1887937_1888885_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.22683e-52
NZ_CP017689.1\|WP_068546401.1\|1897422_1898493_+\|histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	7.70218e-55
NZ_CP017689.1\|WP_068546400.1\|1898492_1899317_+\|response-regulator-transcription-factor	gnl\|CDD\|236956	PRK11697, PRK11697, two-component system response regulator BtsR.	5.16897e-52
NZ_CP017689.1\|WP_068546397.1\|1901900_1902758_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|183082	PRK11302, PRK11302, DNA-binding transcriptional regulator HexR; Provisional.	0
NZ_CP017689.1\|WP_068546413.1\|1883152_1885063_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|236861	PRK11147, PRK11147, ABC transporter ATPase component; Reviewed.	0
NZ_CP017689.1\|WP_068546409.1\|1888941_1889457_-\|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA	gnl\|CDD\|179953	PRK05174, PRK05174, bifunctional 3-hydroxydecanoyl-ACP dehydratase/trans-2-decenoyl-ACP isomerase.	3.23847e-124
NZ_CP017689.1\|WP_068546406.1\|1890615_1892475_+\|excinuclease-ABC-subunit-UvrC	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
NZ_CP017689.1\|WP_068546411.1\|1886971_1887784_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	1.79647e-37

>NZ_CP017689.1|WP_068546405.1|1892613_1893222_+|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MWTIPNQVTLFRIILIPVFIVVYYMHDMMPDLFSKNWSNFAAFGVFWVASVSDALDGYLARRLKQSSRFGAFMDPVADKLMVTIALVLIVSEYRNIWVTIPAVIMIAREIVISALREFMADLGKRGDVAVSELGKWKTAAQMLALMGLIWQPNYPIPLILFDLPADVIIWAAWMFYFFATVFAFVSMFQYLKASWPQLSGKK
>NZ_CP017689.1|WP_068546406.1|1890615_1892475_+|excinuclease-ABC-subunit-UvrC
MNETENKSAIDPKTVFDHQGFLKSVTAQSGVYRMYDEQQTIIYVGKAKDLKKRLSSYFRKDLGSVKTQALVNQIQAIDVTVTHTEGEALILENNYIKKYQPKYNILLRDDKSYPYLVITDHKHPKLGAHRGGKRIKGEYFGPFPTAGAVWESLRLMQKLFPIRQCEDSYYRARSRPCLQYQLKRCSAPCVDKISEQDYKQQVNLARMFLQGKNEQVISTLVSKMEQASVGLEFEQAANFRDQIATLRKVQQQQFVTGITAELDVVGFYRLKNQACIHLLFVRDQKILGSKSYFPNIPAQTSDEEIVQAFISQHYLGQAVEQSHIAKEIVLPIAIESQAELAKLLSEQAEHDVKLSVNVRSERSRYLKLATTNAENALNVKNAHKESMQARFAELHKVFELTQPIERIECFDISHTMGQQTIASCVVFNTEGPLKSDYRRYNVVGITPGDDYAAMSFALNKRYGKVKDGENMPDIIFIDGGKGQLARAEAFFAESSLTKTPMLIGVAKGESRKPGLETLIMAGSHQLISLPATSGALHLVQHVRDESHRFAIAGHRAKRGKVAKKSTIEDIPGIGAKKRQALLKYLGGLQEVKKASVDELTKVPGISTELAKTIHQHFQA
>NZ_CP017689.1|WP_068546407.1|1889965_1890610_+|UvrY/SirA/GacA-family-response-regulator-transcription-factor
MIKVLLVDDHDLVRMGVSRLLADAKGIEVVAEVATGEEAISYCKEQSVDVVLMDMNMPGIGGMEATKRIIRYHPDIKIIVLTVHVEEPFPTKVMQIGASGFLTKNAGPEQMVHAIKAVKAGQRYLTPEIAQQMALSQFNAPDESPFASLSERELQIMMMITRGEKVVDISKQLNLSSKTINSYRYRMFEKLSISNDVELTHLAIRYGMLNSESI
>NZ_CP017689.1|WP_068546408.1|1889675_1889939_+|hypothetical-protein
MNDKPSKKIALTNAEKQKRYRDKQKDQGKKEVRGYLSNEAMECYEKICSQTDWTDSTVLSNAIRITYAAYKNGQIGLLNRWLNENKL
>NZ_CP017689.1|WP_068546409.1|1888941_1889457_-|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA
MEQKNSYDKAGLIQAGTGELFGPGNSKLPSDNMLMMDRIIKITDEGGKYGKGEIIAELDINPDLWFFDCHFKGDPVMPGCLGLDAMWQLVGFFLAWSGGPGLGRALGVGEVKFTGQILPTASKVTYRIDLKRVIKRKLFMGLADGTVEVDGRVIYQATDLKVGLFEDTSKF
>NZ_CP017689.1|WP_068546410.1|1887937_1888885_+|LysR-family-transcriptional-regulator
MDLASRLLLLLEVSELGSFTKVAEHRNVNRSAISKQIVRLEQELGVQLLNRTTRALSLTVAGTEMVSQAIHLRDLLNNSIRLAENYHSEPRGELKISSSTLFGRQYVQQAILKFQVLYPDIRVELLLEDRMVDIVGEGFDLGFRIGKPKESNLMSKQIARNRLLIVAAPEFIEKYGLATTIPKLENMPAVVYSAQGLLIDRFQYLDNSGNEEYFQLNPSYKVNDVEMLINTVLDGNMLTVITAQMVENEILEGKLVPIMTHINLTDYGTFYAVYPHRNAPLKTKLFLDTIKEIVGENVPIWETRIPNFDKMYGRS
>NZ_CP017689.1|WP_068546411.1|1886971_1887784_-|enoyl-CoA-hydratase/isomerase-family-protein
MNKLIITKEAGIATVLIKNPPVNILTIDLINELNQFILSLKDDRETKAVVFKSFHHAFFIAHLDLNVINGTQGGQAASIEFNHMIANIKAMKQLSIAIVDGVARGGGNEFVMACDLAYGTENSAFAQPELFINIPTGGQGAVQFARRLGKGKALQALLTGADFTPQQAERLNIITQYVAKNDMERFLEQLLSTVTAWEVRDIVMYKEIIAASIVDENVGAELELRYFLDRAKEEKTQMIIAAFLKHGGQTEREANDIQGIFVDTANELSV
>NZ_CP017689.1|WP_068546412.1|1885059_1886823_+|DUF3466-family-protein
MRSLIKTTLALSITATLLSPSANAATYSVQDLGLIDKVKHIYGIEYNNLGQVVLSGNTTYNFPVQFENLDLDEDNYDDIINFSERYDESYFYLEEIKGDQKDMLRAGQPDANALEWTKLWLTTRNTEYQQVGDAQVYLFDGQTTEEFIVYDQVIPGTDQLTRSVRDLPKGITDDGWIYGSSPAPAMPLEPFVDDEGDTYVHWIREFNQRAWVSINGAPVVSIMPPEATYGGLSAINDLSNGIAVGSASFEMNPEILKEITDEDEECYKQTGDGDPDDPGNMPLEACISIFRANLYNAQAYKWTLDASGNVIDTEVLGTGIVNQDKDDERVFRSEAVSINSSGIAVGMSHFWWDEDETTPSENERVGLFAAIFADGKVYDFTDRDDWSQSRAVKISDQGIMIGLAYSRTIYPYPSKFYYVDVNKTPFEPIYPDDFFNSSNSEPFDINNNGKIVGRGEHNTDSNPRRHHGFVYDIETDVFADVNDLLSCEDQLAYTIIEARSINDSDQILGTAWYTETRRDSKGELIYDENGEPVIENVLRAVYLDPIAEGEIEDCGEELEENVERKGASFGLLGIFAFMVAGWRRRLS
>NZ_CP017689.1|WP_068546413.1|1883152_1885063_+|ABC-transporter-ATP-binding-protein
MELIRITNAELAFGEGKILDNTELRIKTGERVCLVGRNGAGKSSLMKILMRMQNLDDGQLVISNDVQVAMLAQDPPQSSDQTIFNYVADGLKANGELIRQYHEIIHLVAEDPSEANLEKMSRVQTQLEQNNAWDDEQRIEQVLSKLSLDADQNIGELSGGWRRKIALAQALVTNPDVLLLDEPTNHLDIESVLWLEGFLKQYSGTIVFISHDRAFIRSLSTRIVDLDRGKLTSYPGDYDKYLEQKEHDLQVEEQQNQLFDKRLAEEEVWIRQGIKARRTRNEGRVRSLEKLRLERKARRDVKKQGEMVLSQGERSGKLVFECFNLNMSFNDKTIIDDLDLLINRGDRLALIGANGTGKSTLLKLITEQLVQTSGKMRHGVNLEVAYFDQHRAQLDVDMTVQDAVSDGKQEVAVNGKTRHVLGYLQDFLFSPKRARTPVRALSGGERNRLLLAKLFLKPSNLLILDEPTNDLDIETLELLEMVVGNYPGTVLLVSHDRDFVNNCVNSCLYFNGSGQIEQIVGGYSDVEDYLAYKAEQKKQFDVKPKAPEKIVEKTQNNKSKLSYKEKREFELLPALVEELENKIDELQQEVNSAEFFSKDSDYTKNVLSNLEKAENDLETAYDRWQELEELQEKSSK
>NZ_CP017689.1|WP_068546414.1|1882920_1883166_+|glutaredoxin-family-protein
MENVIYNLYGTEGCHLCDDAELLCQQLLNKDDYRNVDIVSDDTLVELYSTSIPVLEHIESHTALYWPFNLQQLQEFIRGTN
>NZ_CP017689.1|WP_068546404.1|1895611_1895965_+|purine-nucleoside-phosphoramidase
MAEETIFSKIIRQEIPTPLLYQDDLVTAFRDISPQADTHILIIPNKLIPTVNDVQESDELALGRMITVAKKLAADEGIAEDGYRLIMNCNSHGGQEVYHIHMHLVGGQPLGRMLSIK
>NZ_CP017689.1|WP_068546403.1|1896048_1896315_+|hypothetical-protein
MKISIEISLYPLAEEKFKKEIWNFIYKLRDNEQLKVITNGMSTQVFGDYDIAVKTVMDEIKVVHETVGTAVFVCKFIGGDRSEIEDEL
>NZ_CP017689.1|WP_162272306.1|1896404_1897295_+|phosphotransferase
MSNSPLLSEITQGLSHCCFRAIADKQTLFVKVFSERNASVNDHSFIEQQAMIAKLTGDCGLSPKLIDVDKEHRLLINEYVAGQSPKLTASDTEADKEADKQSTQTIKILAECAYRTHQLVLPVSAIKLQKVIQQLLRAVNLSDEQNSDILGRVNQIVDEIAIDKSNLVSCHGDINLNNILLTDHTNCHIGSNLIQLVDWEYACLAEREYEVAMCASINQLSRSQTADLVHYYQQLSSINGVATVKLDNNKVTRYLVICNIINHLWFCLYDLDNAESDSSISGFAIYKFILTTLHQS
>NZ_CP017689.1|WP_068546401.1|1897422_1898493_+|histidine-kinase
MNWKDFIENRNRFFWLLHLGGWLGFALVNYLGSLLHDVRDLFTWMIFLSAYAGALFSIPLRYIYKKAWSFKPIYIALVVFAASYMSGLLWQIVKNITHWEIYKHGFRPDNLLYYTQSAVWSFYIMLSWSLLYFGIKYYQMLEAEKQKVLKANSMANQAQLKMLRYQLNPHFLFNTLNAISTLVMIDDNKTANSMVTKLSDFLRYSLDMDPMKKVTLANEIKALSLYLEIEKVRFEERLTLKFEIQNNCQNALVPSMIFQPLVENAIKHAIAVQEQGGCISISVSRFANDLQLEIADNGPGADIKDGSLSRENGVGLANTQERLATLYDNNYSLVVSDNIPSGVKINIRIPFQVDNS
>NZ_CP017689.1|WP_068546400.1|1898492_1899317_+|response-regulator-transcription-factor
MEKTIKTIIVDDEPLARKGLAIRLGAFEQVDIVAQCTNGREAIEAIINISPDLVFLDIQMPQTNGFEVLKQLNERGIEMPMIVFVTAFDQYAIKAFEVHALDYLLKPVDHERLELALNKVSSRLNRHKDSEHKGKLVKLVSHVTGQDCEQILQDLAQNSEVNITQYSDVLAIKDVGETKLVPTEDILCIDAAGDYMVVHTHTETHILRKTMKELEEILDPKKFIRIHRSTIINKGFIDKFGNHVNGEYYVVLTNLKELKVSRSYKDKVKHAVLG
>NZ_CP017689.1|WP_068546399.1|1899352_1900384_-|ATP-dependent-6-phosphofructokinase
MTKQVKNKTIAVLCSGGDAPGMNAAIRAVTLASLHFNHRIIGFQHGYNGLIDNDYIELDEAKVRDIIHLGGTILKSGRSKEFLTQAGQAKAAENLNANNIDALIVIGGDGSFSGLLNLNKIYQGQLIGIPGTIDNDIDGTENTIGFATAVNTGLDAIDKIRDTADAFERIFLVEVMGRHSGFLALNVGIASAAEQVLTFESFTNPGKELRNISEHIHACREQRGLSSYIIVVAENLWPGGLDKLASDLKEYANIDSTPCVLGYIQRGGSPVAKDRILATKLSIAAISAINEGKHMVMTAESSGNVLFVDINDAIQHKKQVNGSLLTAQNSILDIAEIVKAHKL
>NZ_CP017689.1|WP_068546398.1|1900452_1901886_-|pyruvate-kinase
MPRRTKIVATLGPATDDYNVLRDVIAAGVNVVRLNFSHGVPADHIERANNVRKVAKELNTYVGILGDLQGPKIRVSTFKDGPITLEIGDKFVLDADLGKGLGTKDSVGIDYKELPNDVTAGDILLLDDGRVQLKVESIEGNKVNTITTVGGPLSNNKGINRQGGGLSAAALTDKDKEDIKLAAKIDVDFLAVSFPRDAADMREARLLANEANCNARLVSKIERAEAVNDEKVLDEIILASDVVMVARGDLGVEIGDAELVGKQKHIIARSRQLDRVVITATQMMETMISQPMPTRAEVMDVANAVLDGTDAVMLSAETAAGKYPVETVQAMSKVCLGAEKQRSVNKSGHRNELNFTDISETLAMSAMYAANHLEGVRAIISLSESGKTAKLMSRITSGLPIFCLSRHVKTLSKSAIYRGVYPVSFDSTVSNALSKDVLQAVRTAGLVDFAEGDLVIFTRGDAMETIGATNTLKVLTM
>NZ_CP017689.1|WP_068546397.1|1901900_1902758_-|MurR/RpiR-family-transcriptional-regulator
MNILEKINNEFETFSKSERKVAEVILASPSTVIHASIAALAKQADISEPTVNRFCRRLDTKGYPDFKLHLAQSLANGTPYVNRHVDENDSADEYTTKIFESTMANLEMARKSLDTSLINRAVDVLTQAKKISFFGLGASAIVAHDAQNKFFRFNVPVVYFDDILMQRMSSINSIQGDVVVMISHTGRTKPLVEVAHIARENDAIVIGITDAGSPLAKECNIVLSPVVSEDTDLYMPMASRIAQLTLIDVLATGFTLRRGDKFRDNLKKVKDSLRSSRFDIVNKHL
>NZ_CP017689.1|WP_068546396.1|1903032_1904499_+|glucose-6-phosphate-dehydrogenase
MPEQNLKNAENIVLLGAGGDLSRRKLFAALYQLERENQLATVNKIIGVARNDFDKEQFQQFVIDCLNEFIPKDIEEKPLTRFISRFDYAKVDFSDKKAFKKIKDLIPSKSETLYYLATPPSVYGLICEGLNAHGLDNEYARVIMEKPIGHDLASSKVINDQVNEYFEESQIYRIDHYLGKETVLNLLALRFANSLFSTNWDHNCIDHVQITVAESVGIEGRWGFYDGVGQMRDMVQNHLLQILSLLAMEPPTDLSSENIRDEKLKVLKALRPIDRTNIHEKTVRGQYAKGHLNGGVVPGYLEEEGANKKSTTETFVAIKAEIDNWRWAGVPFYMRTGKRMPCKHSEVVIQFKHQPHNIFGHSFSQLPANKLTIRLQPDEGVELTVMNKVPGMTKNLEISETKLDLSFSDVHDNERVIDAYERLVLSAIHGSQALFIRRDEIEAAWTWADGVLDAWEASNEPPKSYSAGSWGPVSSIALIARDDRSWEE
>NZ_CP017689.1|WP_068546395.1|1904498_1905191_+|6-phosphogluconolactonase
MHHLNEFQSKAELDNQFADVVTANLSQAIAKNGKASIAFSGGSTPKGFFQALSNTDLDWSKVTVTLADDRWVDVDHNDSNTKLIRENLLVNKAKDASFFVLKQGDELDDNSLEALNEQALQVLPLDVVILGMGEDGHTASLFPCSQQISVGLSDTAQPALMKVVPTTAPYERITFNFSALINTSSLYLHVVGDNKKQVLEQALASDNALEMPIRAFLSHPQKTCEIYWTK

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Crispr_ID: NZ_CP017689_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017689_5

3391762-3391855

Orphan

Consensus_repeat	Method
CTTCGGGGCTCACTCCGTTCGAAGAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017689_5

>merge|NZ_CP017689|5|3391762-3391855|CRISPRCasFinder
CTTCGGGGCTCACTCCGTTCGAAGAAAAAATATTCCCGATAATTTTTGATTTTATGGATTCAAGTCCCTTCGGGGCTCACTCCGTTCGAAGAAA

>NZ_CP017689|5|5|3391762-3391855|CRISPRCasFinder
CTTCGGGGCTCACTCCGTTCGAAGAAA	AAATATTCCCGATAATTTTTGATTTTATGGATTCAAGTCC
CTTCGGGGCTCACTCCGTTCGAAGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017689.1\|WP_157726573.1\|3397879_3398332_+\|META-domain-containing-protein	unknown	unknown	gnl\|CDD\|377111
NZ_CP017689.1\|WP_068544309.1\|3393566_3394307_-\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|223619
NZ_CP017689.1\|WP_068544306.1\|3390299_3391367_-\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NZ_CP017689.1\|WP_068544312.1\|3397079_3397655_-\|PhnA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377140
NZ_CP017689.1\|WP_082896999.1\|3394574_3394814_+\|SlyX-family-protein	unknown	unknown	gnl\|CDD\|377222
NZ_CP017689.1\|WP_068544297.1\|3380803_3381703_-\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NZ_CP017689.1\|WP_068544307.1\|3391898_3392774_+\|S1/P1-nuclease	unknown	unknown	gnl\|CDD\|211382
NZ_CP017689.1\|WP_068544299.1\|3383306_3383927_-\|2-dehydro-3-deoxy-6-phosphogalactonate-aldolase	unknown	unknown	gnl\|CDD\|181670
NZ_CP017689.1\|WP_068544300.1\|3384021_3384963_-\|2-dehydro-3-deoxygalactonokinase	unknown	unknown	gnl\|CDD\|377446
NZ_CP017689.1\|WP_068544308.1\|3392974_3393442_+\|Rsd/AlgQ-family-anti-sigma-factor	unknown	unknown	gnl\|CDD\|377324
NZ_CP017689.1\|WP_068544310.1\|3394829_3395021_-\|YheV-family-putative-metal-binding-protein	unknown	unknown	gnl\|CDD\|226060
NZ_CP017689.1\|WP_068544315.1\|3399388_3399613_+\|YheU-family-protein	unknown	unknown	gnl\|CDD\|179903
NZ_CP017689.1\|WP_068544314.1\|3398414_3399389_+\|hydrolase	unknown	unknown	gnl\|CDD\|182883
NZ_CP017689.1\|WP_068544298.1\|3381709_3383272_-\|sodium/solute-symporter	unknown	unknown	gnl\|CDD\|271360
NZ_CP017689.1\|WP_068544305.1\|3389109_3390141_-\|UDP-N-acetylmuramate-dehydrogenase	unknown	unknown	gnl\|CDD\|234593
NZ_CP017689.1\|WP_068544311.1\|3395106_3397020_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|236729
NZ_CP017689.1\|WP_068544302.1\|3385950_3386643_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP017689.1\|WP_068544303.1\|3387407_3388136_-\|type-III-pantothenate-kinase	unknown	unknown	gnl\|CDD\|237350
NZ_CP017689.1\|WP_068544301.1\|3384962_3385718_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP017689.1\|WP_068544304.1\|3388135_3389110_-\|bifunctional-biotin--[acetyl-CoA-carboxylase]-ligase/biotin-operon-repressor-BirA	unknown	unknown	gnl\|CDD\|237010

Protein	Function_ID	Function_description	E-value
NZ_CP017689.1\|WP_157726573.1\|3397879_3398332_+\|META-domain-containing-protein	gnl\|CDD\|377111	pfam03724, META, META domain. Small domain family found in proteins of of unknown function. Some are secreted and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene. Over-expression in L.amazonensis increases virulence. A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.	5.62865e-27
NZ_CP017689.1\|WP_068544309.1\|3393566_3394307_-\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	4.21235e-70
NZ_CP017689.1\|WP_068544306.1\|3390299_3391367_-\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NZ_CP017689.1\|WP_068544312.1\|3397079_3397655_-\|PhnA-domain-containing-protein	gnl\|CDD\|377140	pfam03831, PhnA, PhnA domain.	1.48329e-25
NZ_CP017689.1\|WP_082896999.1\|3394574_3394814_+\|SlyX-family-protein	gnl\|CDD\|377222	pfam04102, SlyX, SlyX. The SlyX protein has no known function. It is short less than 80 amino acids and is found close to the slyD gene. The SlyX protein has a conserved PPH(Y/W) motif at its C-terminus. The protein may be a coiled-coil structure.	6.47903e-16
NZ_CP017689.1\|WP_068544297.1\|3380803_3381703_-\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	1.52606e-87
NZ_CP017689.1\|WP_068544307.1\|3391898_3392774_+\|S1/P1-nuclease	gnl\|CDD\|211382	cd11010, S1-P1_nuclease, S1/P1 nucleases and related enzymes. This family summarizes both S1 and P1 nucleases (EC:3.1.30.1) which cleave RNA and single stranded DNA with no base specificity. S1 nuclease is more active on DNA than RNA. Its reaction products are oligonucleotides or single nucleotides with 5' phosphoryl groups. Although its primary substrate is single-stranded, it may also introduce single-stranded breaks in double-stranded DNA or RNA, or DNA-RNA hybrids. It is used as a reagent in nuclease protection assays and in removing single stranded tails from DNA molecules to create blunt ended molecules and opening hairpin loops generated during synthesis of double stranded cDNA. P1 nuclease cleaves its substrate at every position yielding nucleoside 5' monophosphates, and it does not recognize or act on double-stranded DNA. It is useful at removing single stranded strands hanging off the end of double stranded DNA and at completely cleaving melted DNA for simple DNA composition analysis.	2.60433e-47
NZ_CP017689.1\|WP_068544299.1\|3383306_3383927_-\|2-dehydro-3-deoxy-6-phosphogalactonate-aldolase	gnl\|CDD\|181670	PRK09140, PRK09140, 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed.	5.62028e-67
NZ_CP017689.1\|WP_068544300.1\|3384021_3384963_-\|2-dehydro-3-deoxygalactonokinase	gnl\|CDD\|377446	pfam05035, DGOK, 2-keto-3-deoxy-galactonokinase. 2-keto-3-deoxy-galactonokinase EC:2.7.1.58 catalyzes the second step in D-galactonate degradation.	2.07554e-83
NZ_CP017689.1\|WP_068544308.1\|3392974_3393442_+\|Rsd/AlgQ-family-anti-sigma-factor	gnl\|CDD\|377324	pfam04353, Rsd_AlgQ, Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ. This family includes bacterial transcriptional regulators that are thought to act through an interaction with the conserved region 4 of the sigma(70) subunit of RNA polymerase. The Pseudomonas aeruginosa homolog, AlgQ, positively regulates virulence gene expression and is associated with the mucoid phenotype observed in Pseudomonas aeruginosa isolates from cystic fibrosis patients.	1.06068e-75
NZ_CP017689.1\|WP_068544310.1\|3394829_3395021_-\|YheV-family-putative-metal-binding-protein	gnl\|CDD\|226060	COG3529, COG3529, Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only].	1.48235e-21
NZ_CP017689.1\|WP_068544315.1\|3399388_3399613_+\|YheU-family-protein	gnl\|CDD\|179903	PRK04966, PRK04966, hypothetical protein; Provisional.	7.7654e-34
NZ_CP017689.1\|WP_068544314.1\|3398414_3399389_+\|hydrolase	gnl\|CDD\|182883	PRK10985, PRK10985, putative hydrolase; Provisional.	1.14444e-119
NZ_CP017689.1\|WP_068544298.1\|3381709_3383272_-\|sodium/solute-symporter	gnl\|CDD\|271360	cd10325, SLC5sbd_vSGLT, Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain. vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NZ_CP017689.1\|WP_068544305.1\|3389109_3390141_-\|UDP-N-acetylmuramate-dehydrogenase	gnl\|CDD\|234593	PRK00046, murB, UDP-N-acetylmuramate dehydrogenase.	0
NZ_CP017689.1\|WP_068544311.1\|3395106_3397020_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|236729	PRK10636, PRK10636, putative ABC transporter ATP-binding protein; Provisional.	0
NZ_CP017689.1\|WP_068544302.1\|3385950_3386643_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	4.03903e-56
NZ_CP017689.1\|WP_068544303.1\|3387407_3388136_-\|type-III-pantothenate-kinase	gnl\|CDD\|237350	PRK13322, PRK13322, pantothenate kinase; Reviewed.	5.40465e-55
NZ_CP017689.1\|WP_068544301.1\|3384962_3385718_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.40267e-67
NZ_CP017689.1\|WP_068544304.1\|3388135_3389110_-\|bifunctional-biotin--[acetyl-CoA-carboxylase]-ligase/biotin-operon-repressor-BirA	gnl\|CDD\|237010	PRK11886, PRK11886, bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA.	7.37498e-153

>NZ_CP017689.1|WP_068544306.1|3390299_3391367_-|uroporphyrinogen-decarboxylase
MTNLKNDTYLRALMRQPVDYTPVWMMRQAGRYLPEYKETRKDAGDFMSLCRNTELATEVTIQPLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPKFERPITCAADVKKIGHPDPEGELQYVMNAVRSIRKALDGQVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMMFAEPQTLHLLLDKLADSVISYLNAQIAAGAQSVMVFDTWGGVLSPAMYKEFSLQYMAKIVDGLTRENEGRRVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIEDAKARVGDKVALQGNMDPSMLYAPKERIEQEVKTILNGFGDTGTGHVFNLGHGIHPDVNPEHAGYFIDAVHKFSKPYHK
>NZ_CP017689.1|WP_068544305.1|3389109_3390141_-|UDP-N-acetylmuramate-dehydrogenase
MHYQNYSLEQLNSFALKANAKSVVIAESVDAVRQFSEQLPEQFYILGGGSNSLFIDNYQGTIFCPNIKGIEISETNEDYLLHVSSGEDWHDLVEYCLANNMPGLENLALIPGNCGAAPIQNIGAYGVELAHFCDYVQWFDFQTNKEVRLTAEQCQFGYRDSIFKGALKNKGVIIAIGLRLTKKWQPTLKYQGLNQLGETPTAKQVFDAVVNIRQSKLPDPEVLPNAGSFFKNPVVSHQVYAKIKAQYEQVPAYPANGCDMKLAAGWLIEQSGLKGVSIGGAAVHTLQALVLVNKNNATGQDVVALAQHVQRVVNEKFNVMLEPEVRVIGESGEQLIADIEVVK
>NZ_CP017689.1|WP_068544304.1|3388135_3389110_-|bifunctional-biotin--[acetyl-CoA-carboxylase]-ligase/biotin-operon-repressor-BirA
MAKVVREELIRRLSEGKFVSGQLLAEQLDVSRTAISKHIKALGEMGLDIFSVQGKGYKLASPIHLLNQQQMQDNLRELDCNNMVEVHSIIDSTNSYLMRRLPNNVVHGQACVSEFQSAGRGRRGKQWVSPFSSHLYLSMYWRLEQGIAAAMGVSVVVGLAVSDVLQRHYNLDVELKWPNDIYVEGKKLAGILVELEGQSIGPGNCVIGLGLNINMPQMMAEQIDQPWTDLNRELARQVDRNLLAAQLIASISARLEQHLQFGLAPMILEWQRQDYFYNKPVKLIAGSNETRGICKGINASGALLLEVDGKVQPVYGGEVSLRGG
>NZ_CP017689.1|WP_068544303.1|3387407_3388136_-|type-III-pantothenate-kinase
MDLLVDVGNTQVKFTKVESGVFANIERCLATDFLDIIGQYTNIKRIMLVSVANQSFSQSLQTWAGLNDVEFTQVNTQSETFGIQNSYLQYSTMGADRWLAVLAAEALYPNRNILIIDAGTATTFDLLDANKQHQGGWILPGIDMMMQSLFQNTDNVFGETGVIDSVAFGKSTADNVKYGAWSTTAGAIQTALNVAQQQNLTIDEIILTGGYGEELEKLCKQLGLNNCHFIEQLIFVGLQRFL
>NZ_CP017689.1|WP_068544302.1|3385950_3386643_+|FadR-family-transcriptional-regulator
MAQKHNLTYQLTHDLGKAIVTGRYQIGQGLPTEAELCEQYDVSRSATREAVKMLAAKGLIASRPKKGIQVLPESDWNMFDTDVLGWILSSNPSLTLLKSFTEVRAAIEPQAAALAAVNATFEELEEIEKALARMEAAEKGLDDPLDSDIAFHTGVLKASGNPFIMQLTEFISTALKVSIRYTNATKGESGDIEKHAHILNTIKSRNPEKAHLAVKEILDEALALIESNLS
>NZ_CP017689.1|WP_068544301.1|3384962_3385718_-|SDR-family-oxidoreductase
MSYSSHYPCIKNKVVFITGGASGIGAEMVRCFVGQGAKVAFIDLDEEAGRSLCDELQDKVWFHALNATDENALQQSVQDAAKELGTINVLINNVANDMRHHVSEITEKQWHNCMKINLDPTFFASQAVYPYLKENGGGSIINFSSINAIVGLANMSGYVTAKAGIIGMTRGMAKDFGDDNIRVNAILPGWVATERQLDTWLNAEVEAQWMESMAIKKRILASDVAKLALFLASDDSSMITGQKLVIDGGKI
>NZ_CP017689.1|WP_068544300.1|3384021_3384963_-|2-dehydro-3-deoxygalactonokinase
MTSQYVITVDWGTSFLRAYLCEVSDQTQLKLIDTQIARGVCKCDGEFEKELMTCIAVWEAQYGKLPVYLAGQISSSLGWHNTQYLPCPLKPKDIAFGGINFTANGHDLYILPGTSCQYPDQSFDVMRGEELQILGWLQLDPTHAQGRHMLCLPGTHTKWVLVEDGIIKLFKTAMTGELFDIISNNSIIIEEPSQDFNQDAFNDGANYVLAGDIGDFSHDLFSVRTKQVMEHLSKQKATSYLSGVLIGTDVRAAQRSSHWKLDHVESIHIIGSIKLSECFATVLNLIDCPSKIYDAKQTSIQGFTSIIMQRNNT
>NZ_CP017689.1|WP_068544299.1|3383306_3383927_-|2-dehydro-3-deoxy-6-phosphogalactonate-aldolase
MLQLSINPCIAILRGLQPAQAKDIGDLLYQAGIRIMEVPLNRDNAYKSIEVLQQEMPENCLIGAGTVTTIEQLETLHTMQVKLAISPNTDIAIIKKANDFGMIHTPGVATPSEVYHAYNSGARWLKLFPAGSYGTGHLKALISIAPQDANFVAVGGINANNMQQWMETGAKGVGIGDSIYNEKDSYQQSKVKIEKFSNFTDEINLK
>NZ_CP017689.1|WP_068544298.1|3381709_3383272_-|sodium/solute-symporter
MNLSTLDISVFVFYVVSLIAVAYMVSREKAGHEKNSNDYFLAGNSLPWWAIGASLIAANISAEQIIGMSGSGYKIGLAIASYEWMAAITLMIVGKYFLPIFLEKKIYTMPQFLEQRFDHRVRTVMAVFWLGVYVFVNLTAILWLGALAINTITGVDVVYGMIFLGAFSVAYSLYGGLKAVALTDIIQVVLLVAGGLFLSYMALDLIGGGQGIVAGFNSLVEQTPEKFDMILAEESEHYMDLPGLSVLVGGMWIMNLSYWGFNQYIIQRTLGAKNLREGQKGIAFAAFLKLLMPVIVVLPGIAAVLLVPELQKPDQAYPALLNMMPEGLKGLVFAALVAAIVSSLASMTNSIATIFTMDLYKNDNKPKSEEHYVKVGRIVSLSALVIAMLVAKPLLGQFDQAFQYIQEFTGFFTPGIVVLFFLGMFWKKTTANAGLVAAVGSAVLSFALKMLWPELPFMDRVGLVFVLCMLLAVIVSLIEKKGEHEHAVDLKGIDFSTSKSFNVSTVAVTLILIGFYSAWW
>NZ_CP017689.1|WP_068544297.1|3380803_3381703_-|SMP-30/gluconolactonase/LRE-family-protein
MANVTVGKLLNVIDVTNTLGEGVQWHALSQCIWWTDIQESCLYSYSTKSSQLNKHTMPERVGCFAFIENDPRIIVAFASGIAFYDFSSKSLEWIDKPEEHIKGNRFNDGRVDRQGRFWYGSLVENKESSEQSAFLYMLNSRGKSIAKETNIEIANGLCWSPDGKTLYHADSPQQKIHQYDFNTATTELSNKKLFAKTAPGSFPDGSTIDSDGYLWNAQWGGSRVVRYNPQGEIDLCIDVPVSQPSCVAFGGPNLDWLMITSARQDLSENELSQQPLAGNLFIYQVNGTTGLEENKFILP
>NZ_CP017689.1|WP_068544307.1|3391898_3392774_+|S1/P1-nuclease
MLNKFYLLIFILITSYAWGDKAYALGEKGHYLVCQLAYQQLSAAQQTDVKQLMSYFPESERKRLKKHLRLPKKHQLTFADACSWPDSIKQLKQYKQFNQWHFINVGRDRTIIDSSFVKSNCKLNCIIDAISYHQKQLQSQQKGWLKLQALLFLGHWLGDIHQPLHVSFKSDLGGNKSLIKDASKYCSNLHRVWDSCLINHLNRKTYVIDQTFKIDSKDHYSQDNINYWATQSLKISRLPKTMYCQIIDSHCQPHKQPIILPKNYQLEQQEVLLTQINLAAKRLFLMINSDL
>NZ_CP017689.1|WP_068544308.1|3392974_3393442_+|Rsd/AlgQ-family-anti-sigma-factor
MLTRLEQAQQQWGGSLSAIDNWLNERQEVLVSYYQLAGLAPSDQTDRALPNAADIQAFCQLLMDYLSAGHFEVFDQIVAQCKKNGPDSLALAQKIYPEISKTTDIALAFNDKFAEPEDDSFLESFDASLSVLGQALEERFELEDQLIEALYKKHS
>NZ_CP017689.1|WP_068544309.1|3393566_3394307_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MKFIVKPTLVAVAVMAMMGCQEKEAKPAVLETDLQKQAYALGSSMHLNIADLDEMGIQLDHDLIMAGFEESAAGNGQVDKEQIQQLLMALGQTVQTKQQELAAIEAEKAQAASAAFLSTNAQVDGVVTTESGLQYQVLTAAEGAKPAATDTVKVHYHGTLTDGTIFDSSVDRGEPIEFPLNRVIPGWTEGVQLMSVGSKYKFVIPSNLGYGANPAGQIPANSTLIFEVELLDITTPAPAAEDAAAK
>NZ_CP017689.1|WP_082896999.1|3394574_3394814_+|SlyX-family-protein
MNIMTEQNLLATMQQQIESLETKTAFQDHIIEQLNNEIAVHQEQIRDLVEQLHLIGQRVKDMNSSPVGKVEDETPPPHY
>NZ_CP017689.1|WP_068544310.1|3394829_3395021_-|YheV-family-putative-metal-binding-protein
MKKRFISGAKCPKCNALDTMALYKEHDVEKVTCVSCDFEMTQPDENVEQEVRSTEQVIGVFKP
>NZ_CP017689.1|WP_068544311.1|3395106_3397020_+|ATP-binding-cassette-domain-containing-protein
MIFASEMGLYRGVKTLIKSSSFTVHPGHKVGLVGANGCGKSSLFASLLGELQIDSGSLEIPRNWKIATVKQETPALTQSALDYVIDGDTEYRLLEQKLEQARANNNGSEEAHLLNQIDVIQGYSLPARAGELLHGLGFMQAQLSDSVSSFSGGWRMRLNLAQALISRADLLLLDEPTNHLDLDAVLWLQRWLKRFEGTLVLISHDRDFLDDVIGQILHIEHQHAKMYNGNYSAFERQRAEHLAQQDAMYQKQQREVKHLTSFVDRFRAKATKAKQAQSRLKRLQKLPDLMPAHVDSQFSFQFENPEYMPYPLLSLEHSDCGYSEQAKILTDVKINLVPGSRIGLLGRNGAGKSTLIKSLAGDLALLQGTRFCAQELTIGYFSQHQLEQLRTDETALNQILLAKPEYTELQARNHLGRFGFSGDQALNVIHTMSGGEKARLVLALIVLEKPQLLLLDEPTNHLDLEMRQALVLALQEFSGAIILIAHDRYLLESCVDEFYIVGNGRVEEFDGDIDDYQKWLSDENKAAKSKSKADGQSERQGKEKVDKKEQRKQQAELRQKAAPMRKKTQKLEQQVEKWQQQLEEIESQLALPETYEAENKAKLNELMQQQAKIKPQLEEAEEQWMELEEQIEEIING
>NZ_CP017689.1|WP_068544312.1|3397079_3397655_-|PhnA-domain-containing-protein
MSIEQTLKTRCDSKCELCGSVDSLSVYEVPPVAEPNSDKSVLVCALCESQINSTDGKYDTNHWRCLNDSMWSQVPAVQVMAYRMLKRLDSEGWAQDLLDMMYLEDDVRAWADSAAGDALEADEPTLDNNKAPLAAGDNVVLIKDLVVKGANFTAKRGTAVRGISLTSNPLHIEGRVNGTRIVIISDYVKKM
>NZ_CP017689.1|WP_157726573.1|3397879_3398332_+|META-domain-containing-protein
MNFKNIIAIITAMTITMGCQNNNAAENEENLTLEGHYWVLKTIAGKSAIKGENNKPVSIEFLAENNIYRGFGGCNNYSGSFEKEQNTISFGPARATRKFCQTTMDQESALFEILSKASSYKLSKDTLTVGSDVNQVLAVFVMQGPTPSSK
>NZ_CP017689.1|WP_068544314.1|3398414_3399389_+|hydrolase
MKQTSQFTPAWWLANRHLQTMAGKILRRKQQLPVIEEVLELPDGDFVELAWTEDPDKYPTKPIVFVLHGLEGSIDSHYAKGMMSSIKARGFVGMLMHFRGCGSKPNRQGPSYHSGDTFDVHYCVDWLSKRFAQRQMGILGFSLGGNVLAKYLAEDTSNPFKCAAVLCAPLHLASCAERINRGFSKVYQKYLVDMLKDSTSEKIKLGLVNHLTLNELEGIKTLYDFDHKVTALINGFESANDYYEKASGIYVLNDIQTPTLVIHALDDPFLCHNYIDNLNLDNALVHFEVSKYGGHVGFIGGNNPLKPQYYLEQRVLDFFAGEFS
>NZ_CP017689.1|WP_068544315.1|3399388_3399613_+|YheU-family-protein
MIIPIDQINAETLDNIIESFILREGTDYGLHEWSLDEKKQQLNQQLINGEIVVVYSELHETVNLMPISQFNAQT

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

878723 : 890991

uncultured_Mediterranean_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_068546162.1\|878723_879362_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	6.9e-37	50.3
WP_068546091.1\|879358_879937_+	DedA family protein	NA	NA	NA	NA
WP_068546090.1\|879977_880829_+	peptidoglycan DD-metalloendopeptidase family protein	D7RWE0	Brochothrix_phage	5.4e-05	32.1
WP_082897133.1\|880888_881839_+	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	2.5e-35	34.9
WP_068546089.1\|881922_884499_-	DNA mismatch repair protein MutS	E3T5Q7	Cafeteria_roenbergensis_virus	7.3e-37	22.2
WP_068546088.1\|884960_885983_+	recombinase RecA	A0A2D1GPX2	Mycobacterium_phage	6.1e-112	60.7
WP_068546087.1\|886354_887302_+	homoserine O-succinyltransferase	NA	NA	NA	NA
WP_082897132.1\|887298_890991_+	methionine synthase	A0A140XBC7	Dickeya_phage	1.8e-20	78.0

DBSCAN-SWA_2

2540523 : 2546197

Escherichia_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_068546665.1\|2540523_2541621_-	dTDP-glucose 4,6-dehydratase	A0A291LAD7	Escherichia_phage	1.5e-84	45.8
WP_068546664.1\|2541636_2542509_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	4.8e-33	34.7
WP_068546663.1\|2542520_2543069_-	dTDP-4-dehydrorhamnose 3,5-epimerase	A0A291LA62	Escherichia_phage	1.0e-49	54.5
WP_068546662.1\|2543068_2543944_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	1.5e-95	58.7
WP_068546661.1\|2543946_2544975_-	NAD-dependent epimerase	A0A2K9L4U8	Tupanvirus	7.4e-33	30.1
WP_068546660.1\|2545030_2546197_-	nucleotide sugar dehydrogenase	M1I798	Paramecium_bursaria_Chlorella_virus	9.7e-114	54.2

DBSCAN-SWA_3

2951395 : 2960407

Bacillus_phage(33.33%)

holin,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_068545615.1\|2951395_2952892_+	sulfatase	A0A2K9L727	Tupanvirus	1.0e-22	27.7
WP_068545614.1\|2952912_2954427_+	sulfatase	NA	NA	NA	NA
WP_068545613.1\|2954690_2955062_-	hypothetical protein	NA	NA	NA	NA
WP_068545612.1\|2955142_2955400_-	YfhL family 4Fe-4S dicluster ferredoxin	A0A1B1IWY9	uncultured_Mediterranean_phage	4.3e-22	58.8
WP_068545611.1\|2955425_2956856_-\|tRNA	tRNA 5-hydroxyuridine modification protein YegQ	Q6DW11	Phage_TP	1.6e-134	64.1
WP_068545610.1\|2957014_2957932_-	recombination-associated protein RdgC	A0A067ZG66	Vibrio_phage	1.0e-65	41.3
WP_068545609.1\|2957999_2958329_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_068545608.1\|2958371_2959664_-	phosphate regulon sensor histidine kinase PhoR	W8CYF6	Bacillus_phage	4.3e-30	34.1
WP_068545607.1\|2959714_2960407_-	phosphate regulon transcriptional regulator PhoB	W8CYM9	Bacillus_phage	3.7e-36	36.7

DBSCAN-SWA_4

2973551 : 2981599

Indivirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_068545793.1\|2973551_2974661_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	5.4e-45	34.3
WP_068545597.1\|2974770_2975223_-	transcriptional regulator NrdR	NA	NA	NA	NA
WP_068545596.1\|2975322_2976579_-	serine hydroxymethyltransferase	A0A240F3L3	Aeromonas_phage	2.4e-94	50.5
WP_068545595.1\|2976788_2977127_-	ISC system 2Fe-2S type ferredoxin	NA	NA	NA	NA
WP_068545594.1\|2977129_2978995_-	Fe-S protein assembly chaperone HscA	F2Y2E1	Organic_Lake_phycodnavirus	2.5e-103	38.9
WP_068545593.1\|2979047_2979572_-	co-chaperone HscB	NA	NA	NA	NA
WP_068545592.1\|2979621_2979945_-	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	1.3e-23	47.7
WP_068545591.1\|2979954_2980338_-	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	6.8e-56	81.5
WP_068545590.1\|2980384_2981599_-	IscS subfamily cysteine desulfurase	A0A1X7C038	Faustovirus	4.5e-29	29.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP017689

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection