CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP013420	Burkholderia ubonensis strain MSMB0783 chromosome 1, complete sequence	1 crisprs	DEDDh,csa3,cas3,WYL	0	1	4	0
NZ_CP013422	Burkholderia ubonensis strain MSMB0783 chromosome 2, complete sequence	1 crisprs	DEDDh,cas3,csa3,DinG	0	0	0	0
NZ_CP013421	Burkholderia ubonensis strain MSMB0783 chromosome 3, complete sequence	2 crisprs	PD-DExK,RT	2	2	3	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013420_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013420_1

1709939-1710046

Orphan

Consensus_repeat	Method
TGCCGAGTGCGCCGGTCAATGCGCCGGCCGGGTTACCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013420_1

>merge|NZ_CP013420|1|1709939-1710046|CRISPRCasFinder
TGCCGAGTGCGCCGGTCAATGCGCCGGCCGGGTTACCGCCACCAGCGTTGCCCAATGCGCCGGTCACCGTGCCGAGTGCTCCGGTCAATGCGCCGGCCGGGTTACCGC

>NZ_CP013420|1|1|1709939-1710046|CRISPRCasFinder
TGCCGAGTGCGCCGGTCAATGCGCCGGCCGGGTTACCGC	CACCAGCGTTGCCCAATGCGCCGGTCACCG
TGCCGAGTGCTCCGGTCAATGCGCCGGCCGGGTTACCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013420.1\|WP_060234311.1\|1715241_1717074_-\|peptidase-S1	unknown	unknown	gnl\|CDD\|225490
NZ_CP013420.1\|WP_069238999.1\|1705019_1705529_-\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|176866
NZ_CP013420.1\|WP_060234310.1\|1712731_1714174_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP013420.1\|WP_069239004.1\|1723966_1724368_-\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|226867
NZ_CP013420.1\|WP_060234308.1\|1711191_1711839_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225512
NZ_CP013420.1\|WP_060234313.1\|1722236_1722875_+\|2-hydroxychromene-2-carboxylate-isomerase	unknown	unknown	gnl\|CDD\|239320
NZ_CP013420.1\|WP_029226429.1\|1714332_1715121_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP013420.1\|WP_069238998.1\|1702665_1704306_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP013420.1\|WP_060234351.1\|1720699_1722124_+\|C4-dicarboxylate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270238
NZ_CP013420.1\|WP_069239003.1\|1707988_1708348_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226765
NZ_CP013420.1\|WP_029226428.1\|1719886_1720261_-\|BON-domain-containing-protein	unknown	unknown	gnl\|CDD\|335963
NZ_CP013420.1\|WP_069239002.1\|1707423_1707939_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|237123
NZ_CP013420.1\|WP_004186709.1\|1701262_1701433_-\|rubredoxin	unknown	unknown	gnl\|CDD\|224687
NZ_CP013420.1\|WP_060234312.1\|1717677_1719777_-\|D-(-)-3-hydroxybutyrate-oligomer-hydrolase	unknown	unknown	gnl\|CDD\|313759
NZ_CP013420.1\|WP_069239001.1\|1706632_1707424_-\|anti-sigma-factor	unknown	unknown	gnl\|CDD\|227949
NZ_CP013420.1\|WP_060234309.1\|1711896_1712628_+\|DsbA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|239322
NZ_CP013420.1\|WP_069239000.1\|1705552_1706185_-\|DUF1571-domain-containing-protein	unknown	unknown	gnl\|CDD\|377879
NZ_CP013420.1\|WP_004186661.1\|1704352_1704646_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NZ_CP013420.1\|WP_069239416.1\|1706181_1706601_-\|quinol-oxidase	unknown	unknown	gnl\|CDD\|259885
NZ_CP013420.1\|WP_069238997.1\|1701652_1702519_+\|hydroxymethylpyrimidine/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|238574

Protein	Function_ID	Function_description	E-value
NZ_CP013420.1\|WP_060234311.1\|1715241_1717074_-\|peptidase-S1	gnl\|CDD\|225490	COG2939, COG2939, Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism].	1.86511e-128
NZ_CP013420.1\|WP_069238999.1\|1705019_1705529_-\|polyketide-cyclase	gnl\|CDD\|176866	cd07824, SRPBCC_6, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	7.67747e-70
NZ_CP013420.1\|WP_060234310.1\|1712731_1714174_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.86981e-66
NZ_CP013420.1\|WP_069239004.1\|1723966_1724368_-\|polyketide-cyclase	gnl\|CDD\|226867	COG4460, COG4460, Uncharacterized protein conserved in bacteria [Function unknown].	4.16064e-20
NZ_CP013420.1\|WP_060234308.1\|1711191_1711839_+\|hypothetical-protein	gnl\|CDD\|225512	COG2964, COG2964, Uncharacterized protein conserved in bacteria [Function unknown].	2.51646e-69
NZ_CP013420.1\|WP_060234313.1\|1722236_1722875_+\|2-hydroxychromene-2-carboxylate-isomerase	gnl\|CDD\|239320	cd03022, DsbA_HCCA_Iso, DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-dihydroxynapthalene by a dioxygenase, into cis-o-hydroxybenzylidenepyruvate (cHBPA). This is the fourth reaction in a six-step pathway that converts napthalene into salicylate. HCCA isomerase is unique to bacteria that degrade polycyclic aromatic compounds. It is closely related to the eukaryotic protein, GSH transferase kappa (GSTK).	3.62946e-40
NZ_CP013420.1\|WP_029226429.1\|1714332_1715121_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.51538e-24
NZ_CP013420.1\|WP_069238998.1\|1702665_1704306_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP013420.1\|WP_060234351.1\|1720699_1722124_+\|C4-dicarboxylate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270238	cd13520, PBP2_TAXI_TRAP, Substrate binding domain of TAXI proteins of the tripartite ATP-independent periplasmic transporters; the type 2 periplasmic binding protein fold. This group includes Thermus thermophilus GluBP (TtGluBP) of TAXI-TRAP family and closely related proteins. TRAP transporters are ubiquitous in prokaryotes, but absent from eukaryotes. They are comprised of an SBP (substrate-binding protein) of the DctP or TAXI families and two unequally sized integral membrane components. Although TtGluBP is predicted to be an L-glutamate and/or an L-glutamine-binding protein, the substrate spectrum of TAXI proteins remains to be defined. A sequence-homology search also shows that TtGluBP shares low sequence homology with putative immunogenic proteins of uncharacterized function. The substrate-binding domain of TAXI proteins belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and tworeceptor cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.08858e-30
NZ_CP013420.1\|WP_069239003.1\|1707988_1708348_-\|hypothetical-protein	gnl\|CDD\|226765	COG4315, COG4315, Uncharacterized protein conserved in bacteria [Function unknown].	1.63879e-36
NZ_CP013420.1\|WP_029226428.1\|1719886_1720261_-\|BON-domain-containing-protein	gnl\|CDD\|335963	pfam04972, BON, BON domain. This domain is found in a family of osmotic shock protection proteins. It is also found in some Secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes.	1.02577e-10
NZ_CP013420.1\|WP_069239002.1\|1707423_1707939_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|237123	PRK12511, PRK12511, RNA polymerase sigma factor; Provisional.	1.61268e-41
NZ_CP013420.1\|WP_004186709.1\|1701262_1701433_-\|rubredoxin	gnl\|CDD\|224687	COG1773, COG1773, Rubredoxin [Energy production and conversion].	1.12689e-20
NZ_CP013420.1\|WP_060234312.1\|1717677_1719777_-\|D-(-)-3-hydroxybutyrate-oligomer-hydrolase	gnl\|CDD\|313759	pfam10605, 3HBOH, 3HB-oligomer hydrolase (3HBOH). D-(-)-3-hydroxybutyrate oligomer hydrolase (also known as 3HB-oligomer hydrolase) functions in the degradation of poly-3-hydroxybutyrate (PHB). It catalyzes the hydrolysis of D(-)-3-hydroxybutyrate oligomers (3HB-oligomers) into 3HB-monomers.	0
NZ_CP013420.1\|WP_069239001.1\|1706632_1707424_-\|anti-sigma-factor	gnl\|CDD\|227949	COG5662, COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription].	1.23176e-21
NZ_CP013420.1\|WP_060234309.1\|1711896_1712628_+\|DsbA-family-oxidoreductase	gnl\|CDD\|239322	cd03024, DsbA_FrnE, DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	8.82393e-82
NZ_CP013420.1\|WP_069239000.1\|1705552_1706185_-\|DUF1571-domain-containing-protein	gnl\|CDD\|377879	pfam07608, DUF1571, Protein of unknown function (DUF1571). A family of paralogous proteins in Rhodopirellula baltica.	1.8799e-10
NZ_CP013420.1\|WP_004186661.1\|1704352_1704646_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	2.59054e-54
NZ_CP013420.1\|WP_069239416.1\|1706181_1706601_-\|quinol-oxidase	gnl\|CDD\|259885	cd04223, N2OR_C, The C-terminal cupredoxin domain of Nitrous-oxide reductase. Nitrous-oxide reductase participates in nitrogen metabolism and catalyzes the last step in dissimilatory nitrate reduction, the two-electron reduction of N2O to N2. It contains copper ions as cofactors in the form of a binuclear CuA center at the site of electron entry and a tetranuclear CuZ centre at the active site. The C-terminus of Nitrous-oxide reductase is a cupredoxin domain.	0.00155881
NZ_CP013420.1\|WP_069238997.1\|1701652_1702519_+\|hydroxymethylpyrimidine/phosphomethylpyrimidine-kinase	gnl\|CDD\|238574	cd01169, HMPP_kinase, 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of the hydroxyl group of HMP to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate (HMP-P) and then the phophorylation of HMP-P to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine pyrophosphate (HMP-PP), which is the substrate for the thiamine synthase coupling reaction.	8.68892e-72

>NZ_CP013420.1|WP_069239003.1|1707988_1708348_-|hypothetical-protein
MKTMMVALALTAAIARPAAAELPQVSGGKLVDEDRMTLYAFDHDAPGKSTCTGACVANWPPALADGYDHAAGPLTLVARDDGSKQWAYRGRPLYRWKMDGKPGEAGGDGMGGMWHVARP
>NZ_CP013420.1|WP_069239002.1|1707423_1707939_-|sigma-70-family-RNA-polymerase-sigma-factor
MSYESDLLVWLPRLTRYARALTGDPAWADDLVQDTLERALNKPPRVDGNLRAWLLTLLRHRFIDQLRARREIAVDDATAPWQTMAAPAGEISGLLLRDVQRALYRLPVEQREVLLLVALEELSYQEAAQVLAVPVGTVMSRLARAREHMRALLSGEPPTHGTAALRVIGKT
>NZ_CP013420.1|WP_069239001.1|1706632_1707424_-|anti-sigma-factor
MDDEPRTPSHDADETASAQLLSALLDGELSGPERREVLERLRSDPQSADRFAHYRAQRAALQALFPLPGAAPVLFVQRRASRRHAAAYAFAGLAAGLLLGLALHAGWTAFGAAPAFAARADIAYAVYALDRDHPVEVGAHDAGDAARLTGWLSARLGRPVRAPSLAEYGYTLIGGRLLPGDAGPAAQLMYQRADGARVTLYMTAYDARRLAPRALSSQGRHTYFWSDRGIGYALSGDGDERRLREIAMEACGALGGSTDAWKG
>NZ_CP013420.1|WP_069239416.1|1706181_1706601_-|quinol-oxidase
MNPKILKLLTAGALAAGTALARADATVPTRVPVDADGVQRVAIVGGSYFFRPALVIVRADVPVELTVSAEPGVVPHSFEIDAPQAGIAVRTELSTTPRTFRFTPTQAGRFAYYCTHRLLFFKSHRDRGMEGVLEVEGAP
>NZ_CP013420.1|WP_069239000.1|1705552_1706185_-|DUF1571-domain-containing-protein
MIAALLAASLIGASMTADPVTVAHAHFEQVHSYRATIRSSARSGEHAEIHYAYLKPGFVRMDFVSPHHGAVLAYDPGDGKVRVRPFGAHLPPALSLAPTNPLVRDPSGHRVDQSDVGELLRNVRALQEGGVTVLQGEEPVGGRTALRVTVTGAPAHAVAGVHRYQLWLDAEDGFPLKVVSFADGDDRPLETVTLDDVEIDVAFPARFFAP
>NZ_CP013420.1|WP_069238999.1|1705019_1705529_-|polyketide-cyclase
MAEYRFSTTWRVDAPLAAVWNAIYQADMWPDWWKGAERTVEVECGDPHGVGALHRYTWKGALPYRLSFDMRVLRVEPMRVLEGRASGAVEGDGRWSFAGDAERTVVRYDWHIRTHVRWMNWLAPLARPLFKWNHDVVMREGARGLAQRLGTTVETDGRTFRPVAGCPDM
>NZ_CP013420.1|WP_004186661.1|1704352_1704646_-|co-chaperone-GroES
MNLRPLHDRVIVKRLDQETKTASGIVIPDAAAEKPDQGEVLAIGPGKRDDKGAPIALDVKVGDRVLFGKYAGQTVKVDGQELLVMREEDIMAVVNAK
>NZ_CP013420.1|WP_069238998.1|1702665_1704306_-|chaperonin-GroEL
MAAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGSISANSDSSIGDRIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQVAKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAANIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALIRARTAIAGLTGVNADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNAATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEEAPMPGGMPGGMGGMGMDM
>NZ_CP013420.1|WP_069238997.1|1701652_1702519_+|hydroxymethylpyrimidine/phosphomethylpyrimidine-kinase
MSSNAPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDVVAAQARMLLEDMPVAAFKIGATTRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNLDAALAHLLSQGCEYILASEAGSHRLVNTLYGEEGQIREDMWDRTPHRLMGLTDTLGAAIAALLANGQEPPEAVREAQEYLYQAVRDAFRPGMGAYLPDRFFWARSNEETDTPRATKVEPVPRTSHRH
>NZ_CP013420.1|WP_004186709.1|1701262_1701433_-|rubredoxin
MEYKSWMCLICGWIYDEEAGLPEEGIAPGTRWEDVPINWTCPECGARKEDFEMVQI
>NZ_CP013420.1|WP_060234308.1|1711191_1711839_+|hypothetical-protein
MRKKKSPVKDLLLSRYAPLADGIATLFFPYAEVVIHDLRDQTVLYLANNLSKREVGDDSALEEIDHSARERVIGPYEKLNWDGRRMRCVSNILFDDEGHPAGMMCINFNIAVFDDVRATLDLFIKGAGVVAQPDELFRDDWQERINTFLHGWLRERQIGLNGLTREHRRELVEALYAEGAFRGKSAANYVANVLGMGRATVYKHLKHLKDTQGDA
>NZ_CP013420.1|WP_060234309.1|1711896_1712628_+|DsbA-family-oxidoreductase
MPTASSPALRPTLTVEIWSDLICPWCWIGKRRFDEALAAFAHADRVDVALRAYRLFPGQPVEPVEAMLAGKYRLAPAQVDQMLRQVTDAAASVGLRYDLPGTLVGDTLDGHRLVKLAETTGRAHALTERLYRAYFSEHGVLFDHGALADLAVDAGLERAAVEAVLRSDAYRNEVDADVARAEQIGGRGVPLFVFGGRYAVSGAQPADVFAQALEQAWQDGIVAIGGDDAAACGPDGCALPQRA
>NZ_CP013420.1|WP_060234310.1|1712731_1714174_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MTHGIHGEKRWYTLIVLCLGVLMIVLDNTIVNVALPSISADLHFSETALVWVVNAYMLTFGGCLLLGGRLGDLYGHRRMFLAGLTVFTLASLACGVAQSQAMLIAARAVQGFGGAIVSAVSLSLIMNLFTETGERARAMGVYGFVCAGGGSIGVLLGGLLTSALSWHWIFLVNLPIGIAVYALCTALLPRTRAPAASARLDVAGAVTVTASLMLAVYGIVNGNEAGWLSTQTVALVGAAAALLALFVAIEARVAHPLMPLTLFAKRNVALANVIGVLWAAAMFAWFFLSALYMQRVLGYQPLQVGLAFLPANLIMAAFSLGLSARIVMRFGIRGPIAAGLLLAACGLALFARAPVDGGFVWHVLPGMALLGVGAGVAFNPVLLAAMGDVDPADSGLASGIVNTAFMMGGALGLAVLASLAAARTDALAASQAAPLDALNGGYHVAFAFGAVFAAAAALIGLALRIRRQALAGSGVGSAMH
>NZ_CP013420.1|WP_029226429.1|1714332_1715121_+|sulfite-exporter-TauE/SafE-family-protein
MSLPHIDLLYSLSGLFVGILVGLTGVGGGSLMTPILVLLFGVHPATAVGTDLLYAAATKATGTLVHGLKGSVDWRITGRLAAGSVPASAVTLWILHTYGMHTPAAARLIQLVLGGALLLTSLALIFRPQLTALAARNPLAPSPARTLWSTVLTGAVLGVLVSMTSVGAGAIGVTVLLLLYPALATTRIVGSDIAHAVPLTLIAGMGHWLLGSVDWSMLLSLLIGSLPGIVIGSVLSTRAPERLLRNLLASTLVAVGLRLVLA
>NZ_CP013420.1|WP_060234311.1|1715241_1717074_-|peptidase-S1
MTTLKSLKDGFALFGTTLSGPLVAATAAALLVTGCGGDDGASPSAAAAAATAANTPASGAATNAAQADQPFVDTDVYGTGPNDAVTDATEGAAVVHRQVSIGGKVVKYTATAGHLTTIDPVTSQPNAKMFYVAYTQDNPDPSKPRPVTFFYNGGPGSSSVYLLLGSFGPKRLQSSFPNFTPPAPYKLLDNPDSLLDRSDLVFINPVGTGYSAAIAPAKNKDFWGVDQDARSIDRFIQRYLTKYSRWNSPKFLFGESYGTARSAVVSWALHEDGIELNGITLQSSILDYANALSAVGTFPTLAADAFYWKKSTVTPTPTDLDAYMVQARNYADNVLAPLAQAPNPQDGGFVNVRLNLNLQTAQQMGSYIGTDPVSLIQTFGNPAALGNVPSSNDNPPYTFFLTLVPGIQIGQYDGRANYTGKGIAPYILPNSGGNDPSINNIGGAYTVLWNSYLNTDLKYTSTSSFVDLNDQVFNNWDFSHTDPTGANRGGGNTLYTAGDLASSMSLNPDLKVLSANGYFDAVTPFHQTELTLAQMPLDPTIKAQNLTIKNYPSGHMIYLNDASRTALKGDLGNFYDGILANRAALQRVQKLQMRAQQLRQQKLEQQQQLH
>NZ_CP013420.1|WP_060234312.1|1717677_1719777_-|D-(-)-3-hydroxybutyrate-oligomer-hydrolase
MTKLRWGRRVGFGAALAAVVTLFGACNGNETRDGNPLPGFIAGSVRTTAYDGASDDLLTAGLGKSGLASAVPPAFANPARPTAAELRRLAIWSNYRAIVDMSANGGYGRFWGPNVDLDGNDTLGEGRIAGTEYIAYSDDGSGRRNVTLLVQVPTGFDPTQPCIVTATSSGSRGVYGAISAAGEWGLKRGCAVAYNDKGGGNGAHELGSDTVTLIDGTLANAVLAGNASLFTANVSSGELAAYNAQFPNRYAFKHAHSQQNPEQDWGRVTLQAVEFAYWALNEQFGPLIDGTRHGVRYRPGDITTIAASVSNGGGAALAAAEQDTRNWITAVVVGEPQVNVRLAPNAVVRQGGAPVPSFGRPLADYATFANLMQPCAAAASALAGAPYLTALPSTVTQSIRAQRCATLAAAGLVAGADQQSQAADALAQLHAAGYLADSDMLQAPMWDSQAIPAIAVTYANAYTRSRVVDNLCNFSFATTNAATGAVAPPAASPMPSVFGAGNGVPPTNGINLVFNTGPASGVDHRLATPDASFAGALCLRQLWTNGQLNMPANVDAVRVNANLQGKPAIIVHGRSDALVPVNHASRAYVAQNSISEGGRSQLAFYEVTNGQHFDAFLPVAGFDTRFVPVHYYDLQALNLMWRHLKNGAPLPPSQVIRTVPRGGTPGAAPALTTANLPPISAAPGGNAITVGAGALDVPF
>NZ_CP013420.1|WP_029226428.1|1719886_1720261_-|BON-domain-containing-protein
MKSIVSRALGALGVAAVAACLSGSVYAQSSEPAAPEAPAAAKSASKAAAKSAKQANRKLGYAVRKAISKENGVDVANIVVRSKGGAITLEGSVPDAAQIEKAEAAAKGVPGVTSVSNKLSVQPQ
>NZ_CP013420.1|WP_060234351.1|1720699_1722124_+|C4-dicarboxylate-ABC-transporter-substrate-binding-protein
MKPLLRPRRPPRILARFVAVSWRDLALSVGPTVLLAVAAVWLAIRMIQPAPPSTLVISSGPPGSTYWNAAQKYKAILAKNGVTLDVESSEGSAQNLERLSNPKATVDVGFVQSGIGPKTRDEHLVALGSIGYVPLAIMYRGPIVARLSDFNGKRLALGPEGSGARELSLALLKMNGIAPGGTTALLPIAGEDAADALLAGKIDAAFLSGDSTQIPVMAKLFRAPGVHVYSFTQAEAYARRFPYLTAITLPEGVYDLGRNLPPADIHTVAPTIELVARDALHPALSDLLIEAAREVHGHATILQHAGEFPSALTRSFPLSDDAARYYKSGKTFLYRRLPFWVASLVDRLLVIVVPLIVVLIPGVRVVPALYGWRVRSRIYRWYGALIALERNALGEHTAAERVELLDRLDDIEDSVNRMKMPLAYAGQFYVLREHIGFVRERLTAHEADPHGRPHDAPHASGGDGAPPRATPGSA
>NZ_CP013420.1|WP_060234313.1|1722236_1722875_+|2-hydroxychromene-2-carboxylate-isomerase
MTTGLDTAQPAWFFDFVSPFSYLLLEQYERWPDVPFAPVAVSLYDLQRHWGQRPSADVPAKRVFTYRHALFRAEQLGIRFKMPPAHPFDSDKALRLAIALRADLATVREMFRFVWRDGNDPSTPDGFAALCERVGVGHGDQLIEFEETAAQLRRHIDDAIALGVFGVPTFWMSKQLFWGEDALPMVLYCARTPTWLETREVKRISALPKGRA
>NZ_CP013420.1|WP_069239004.1|1723966_1724368_-|polyketide-cyclase
MSDPQIYLDALAASVVAIERWLSGADSEPAAVDALLADFAADFTMILTDGRELDHDGMRALFAKLAGAKPGLRIGLSETHVLVSDDRHAVITYLEAQHAAAGELPARRATAVFERDAAGAVRWTHLQETFCTA

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP013420_1	1.1\|1709978\|30\|NZ_CP013420\|CRISPRCasFinder	1709978-1710007	30	NZ_CP035000	Rhizobium acidisoli strain FH23 plasmid pRapFH23b, complete sequence	175761-175790	5	0.833
NZ_CP013420_1	1.1\|1709978\|30\|NZ_CP013420\|CRISPRCasFinder	1709978-1710007	30	NC_011368	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence	1079785-1079814	5	0.833
NZ_CP013420_1	1.1\|1709978\|30\|NZ_CP013420\|CRISPRCasFinder	1709978-1710007	30	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	223423-223452	5	0.833
NZ_CP013420_1	1.1\|1709978\|30\|NZ_CP013420\|CRISPRCasFinder	1709978-1710007	30	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	223552-223581	5	0.833
NZ_CP013420_1	1.1\|1709978\|30\|NZ_CP013420\|CRISPRCasFinder	1709978-1710007	30	NZ_CP030263	Ensifer adhaerens strain Corn53 plasmid AA, complete sequence	786510-786539	8	0.733
NZ_CP013420_1	1.1\|1709978\|30\|NZ_CP013420\|CRISPRCasFinder	1709978-1710007	30	NZ_CP015881	Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence	1386732-1386761	8	0.733
NZ_CP013420_1	1.1\|1709978\|30\|NZ_CP013420\|CRISPRCasFinder	1709978-1710007	30	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	225944-225973	8	0.733
NZ_CP013420_1	1.1\|1709978\|30\|NZ_CP013420\|CRISPRCasFinder	1709978-1710007	30	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	226529-226558	8	0.733
NZ_CP013420_1	1.1\|1709978\|30\|NZ_CP013420\|CRISPRCasFinder	1709978-1710007	30	NZ_CP024310	Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence	269207-269236	8	0.733
NZ_CP013420_1	1.1\|1709978\|30\|NZ_CP013420\|CRISPRCasFinder	1709978-1710007	30	NZ_CP048428	Rhizobium daejeonense strain KACC 13094 plasmid unnamed4, complete sequence	45382-45411	9	0.7

1. spacer 1.1|1709978|30|NZ_CP013420|CRISPRCasFinder matches to NZ_CP035000 (Rhizobium acidisoli strain FH23 plasmid pRapFH23b, complete sequence) position: , mismatch: 5, identity: 0.833

caccagcgttgcccaatgcgccggtcaccg	CRISPR spacer
aatcggcattgccctatgcgccggtcaccg	Protospacer
 *.*.**.****** ***************

2. spacer 1.1|1709978|30|NZ_CP013420|CRISPRCasFinder matches to NC_011368 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence) position: , mismatch: 5, identity: 0.833

caccagcgttgcccaatgcgccggtcaccg	CRISPR spacer
aatcggcattgccctatgcgccggtcaccg	Protospacer
 *.*.**.****** ***************

3. spacer 1.1|1709978|30|NZ_CP013420|CRISPRCasFinder matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 5, identity: 0.833

caccagcgttgcccaatgcgccggtcaccg	CRISPR spacer
cgccgacgttgcccagagcgccggtcaccg	Protospacer
*.**..*********. *************

4. spacer 1.1|1709978|30|NZ_CP013420|CRISPRCasFinder matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 5, identity: 0.833

caccagcgttgcccaatgcgccggtcaccg	CRISPR spacer
cgccgacgttgcccagagcgccggtcaccg	Protospacer
*.**..*********. *************

5. spacer 1.1|1709978|30|NZ_CP013420|CRISPRCasFinder matches to NZ_CP030263 (Ensifer adhaerens strain Corn53 plasmid AA, complete sequence) position: , mismatch: 8, identity: 0.733

caccagcgttgcccaatgcgccggtcaccg	CRISPR spacer
gttgggcgttgcccaaagcgccggtcacgc	Protospacer
  . .*********** ***********

6. spacer 1.1|1709978|30|NZ_CP013420|CRISPRCasFinder matches to NZ_CP015881 (Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence) position: , mismatch: 8, identity: 0.733

caccagcgttgcccaatgcgccggtcaccg	CRISPR spacer
gttgggcgttgcccaaagcgccggtcacgc	Protospacer
  . .*********** ***********

7. spacer 1.1|1709978|30|NZ_CP013420|CRISPRCasFinder matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 8, identity: 0.733

caccagcgttgcccaatgcgccggtcaccg	CRISPR spacer
gcgtgtcgttgcccaatccgccggtcagcg	Protospacer
   .. *********** ********* **

8. spacer 1.1|1709978|30|NZ_CP013420|CRISPRCasFinder matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 8, identity: 0.733

caccagcgttgcccaatgcgccggtcaccg	CRISPR spacer
gcgtgtcgttgcccaatccgccggtcagcg	Protospacer
   .. *********** ********* **

9. spacer 1.1|1709978|30|NZ_CP013420|CRISPRCasFinder matches to NZ_CP024310 (Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence) position: , mismatch: 8, identity: 0.733

caccagcgttgcccaatgcgccggtcaccg	CRISPR spacer
gcgcggcgttgcgcaatgcgccggtcgctc	Protospacer
   *.******* *************.*.

10. spacer 1.1|1709978|30|NZ_CP013420|CRISPRCasFinder matches to NZ_CP048428 (Rhizobium daejeonense strain KACC 13094 plasmid unnamed4, complete sequence) position: , mismatch: 9, identity: 0.7

caccagcgttgcccaatgcgccggtcaccg	CRISPR spacer
ggccagcattgcccaatgcgccgagcgtac	Protospacer
 .*****.***************. *..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

859102 : 951395

101

Burkholderia_virus(28.57%)

tRNA,head,terminase,tail,protease,portal,capsid,holin

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_069239392.1\|859102_861034_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_010092449.1\|861388_862693_-	MFS transporter	Q6JIH2	Burkholderia_virus	3.7e-45	28.6
WP_010092450.1\|862926_864606_-	SpoVR family protein	NA	NA	NA	NA
WP_010092451.1\|864602_865871_-	YeaH/YhbH family protein	A0A219UQP6	Bacillus_phage	2.4e-09	37.2
WP_010092452.1\|865995_867918_-	PrkA family serine protein kinase	NA	NA	NA	NA
WP_069239393.1\|868446_870240_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	3.4e-09	32.3
WP_060238819.1\|870433_871375_-	ribokinase	NA	NA	NA	NA
WP_060238823.1\|871371_872403_-	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	1.8e-34	31.5
WP_060238826.1\|872470_873490_-	ABC transporter permease	NA	NA	NA	NA
WP_060238828.1\|873486_875091_-	sugar ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.1e-11	29.3
WP_010092460.1\|875235_876186_-	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_060238830.1\|876537_877464_-	CysB family HTH-type transcriptional regulator	NA	NA	NA	NA
WP_060238832.1\|877539_878595_-	sulfate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.1e-28	35.1
WP_060238836.1\|878608_879556_-	sulfate ABC transporter permease subunit CysW	NA	NA	NA	NA
WP_042583970.1\|879552_880458_-	sulfate ABC transporter permease subunit CysT	NA	NA	NA	NA
WP_010092465.1\|880548_881586_-	sulfate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_010092466.1\|881870_882518_+	transcriptional repressor LexA	A0A2H4JG58	uncultured_Caudovirales_phage	3.6e-09	50.0
WP_010092467.1\|882544_882880_+	hypothetical protein	NA	NA	NA	NA
WP_069238768.1\|882909_883617_+	DUF2939 domain-containing protein	NA	NA	NA	NA
WP_069238769.1\|883728_884226_-	universal stress protein	NA	NA	NA	NA
WP_060238840.1\|884579_885494_+	nodulation factor ABC transporter ATP-binding protein NodI	W6JKT0	Anomala_cuprea_entomopoxvirus	7.1e-27	28.0
WP_060238843.1\|885500_886334_+	nodulation protein NodJ	NA	NA	NA	NA
WP_088580180.1\|886382_886868_-	hypothetical protein	NA	NA	NA	NA
WP_060238848.1\|886957_888016_-	hypothetical protein	NA	NA	NA	NA
WP_069238770.1\|888012_889152_-\|tRNA	tRNA 2-selenouridine(34) synthase MnmH	NA	NA	NA	NA
WP_060237313.1\|889655_890708_-	NADP(H)-dependent aldo-keto reductase	NA	NA	NA	NA
WP_069238772.1\|890943_891567_+	phospholipase D family protein	A0A1B2LRT6	Wolbachia_phage	1.0e-16	35.0
WP_046427098.1\|891727_891943_-	hypothetical protein	NA	NA	NA	NA
WP_011884713.1\|892171_893143_+	sensor domain-containing diguanylate cyclase	NA	NA	NA	NA
WP_069238773.1\|893244_893718_-	VOC family protein	A0A2K9L1J4	Tupanvirus	1.8e-18	37.4
WP_011884709.1\|893988_894297_-	hypothetical protein	NA	NA	NA	NA
WP_014722976.1\|894417_895161_+	DUF695 domain-containing protein	NA	NA	NA	NA
WP_011884706.1\|895773_896238_+	hypothetical protein	NA	NA	NA	NA
WP_034193189.1\|896317_897757_-	PAS domain S-box protein	NA	NA	NA	NA
WP_080484218.1\|898215_899133_+	hypothetical protein	NA	NA	NA	NA
WP_080484219.1\|899906_900731_+	TIR domain-containing protein	K7PLZ9	Enterobacterial_phage	2.1e-62	58.4
WP_069238774.1\|900762_901449_-	hypothetical protein	Q8W6R8	Burkholderia_virus	4.7e-100	74.3
WP_059461727.1\|901527_901782_+	hypothetical protein	NA	NA	NA	NA
WP_069238775.1\|901878_902697_-	hypothetical protein	Q3HQV2	Burkholderia_phage	8.0e-46	42.8
WP_069238776.1\|902829_903318_-	DUF2514 family protein	Q3HQV1	Burkholderia_phage	7.8e-57	75.9
WP_069238777.1\|903317_903815_-	lysozyme	Q3HQU9	Burkholderia_phage	2.2e-75	83.6
WP_034193187.1\|903807_904020_-\|holin	holin	Q3HQU8	Burkholderia_phage	2.0e-17	65.7
WP_080484221.1\|904061_904778_-	hypothetical protein	C7BGD6	Burkholderia_phage	7.9e-90	65.5
WP_069238778.1\|905088_908481_-\|tail	phage tail protein	A4JX16	Burkholderia_virus	0.0e+00	64.3
WP_069238779.1\|908482_909058_-\|tail	tail assembly protein	Q6JIL3	Burkholderia_virus	7.2e-70	68.7
WP_059694696.1\|909061_909805_-	C40 family peptidase	A4JX14	Burkholderia_virus	3.3e-107	72.1
WP_059694698.1\|909851_910532_-\|tail	phage minor tail protein L	Q6JIL5	Burkholderia_virus	1.6e-95	73.6
WP_080484223.1\|910528_912019_-\|tail	tail fiber domain-containing protein	NA	NA	NA	NA
WP_069238781.1\|912015_912357_-\|tail	phage tail protein	C7BGC9	Burkholderia_phage	5.7e-30	57.3
WP_155121855.1\|912357_915201_-\|tail	phage tail tape measure protein	Q6JIL8	Burkholderia_virus	3.9e-55	34.6
WP_080484224.1\|915193_915634_-	hypothetical protein	A0A1W6JP15	Morganella_phage	6.4e-10	32.2
WP_155121856.1\|915626_915806_-	hypothetical protein	NA	NA	NA	NA
WP_034193080.1\|915919_916342_-	hypothetical protein	NA	NA	NA	NA
WP_034193184.1\|916381_917020_-	hypothetical protein	NA	NA	NA	NA
WP_051974404.1\|917065_917467_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_051974403.1\|917459_917792_-\|head	phage head closure protein	NA	NA	NA	NA
WP_069238783.1\|917788_918463_-	hypothetical protein	NA	NA	NA	NA
WP_034193077.1\|918466_918745_-	hypothetical protein	NA	NA	NA	NA
WP_059461710.1\|918808_920065_-\|capsid	phage major capsid protein	C7BGH0	Burkholderia_phage	4.0e-105	53.4
WP_069238784.1\|920159_920906_-\|protease	Clp protease ClpP	C7BGG9	Burkholderia_phage	1.2e-48	55.3
WP_059568126.1\|920899_922258_-\|portal	phage portal protein	Q6JIM9	Burkholderia_virus	1.7e-53	36.3
WP_059723478.1\|922254_923910_-\|terminase	terminase large subunit	A0A0P0ZEI4	Stx2-converting_phage	1.5e-232	71.6
WP_069238785.1\|923913_924396_-\|terminase	terminase small subunit	Q3HQS6	Burkholderia_phage	4.4e-36	61.0
WP_080484318.1\|924509_924770_-	HNH endonuclease	NA	NA	NA	NA
WP_069238787.1\|924851_925199_-	hypothetical protein	A2I2Y8	Vibrio_virus	5.8e-30	63.2
WP_059461704.1\|925305_925884_-	hypothetical protein	Q3HR05	Burkholderia_phage	3.1e-20	35.4
WP_034193070.1\|925938_926184_-	hypothetical protein	Q3HR04	Burkholderia_phage	8.5e-12	46.9
WP_131929091.1\|926180_926495_-	hypothetical protein	NA	NA	NA	NA
WP_069239395.1\|926479_926917_-	DUF1364 family protein	Q6JIF7	Burkholderia_virus	5.0e-63	81.6
WP_059461701.1\|926949_927204_-	hypothetical protein	NA	NA	NA	NA
WP_069238788.1\|927200_927557_-	DUF4406 domain-containing protein	H2BD42	Pseudomonas_phage	4.7e-27	53.8
WP_059495995.1\|927553_927901_-	winged helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_155121907.1\|927900_928260_-	DUF1064 domain-containing protein	A4JX56	Burkholderia_virus	7.3e-28	57.7
WP_069239396.1\|928460_929453_-	helix-turn-helix domain-containing protein	Q8W6P0	Burkholderia_virus	4.4e-107	67.1
WP_069238791.1\|929464_930286_-	hypothetical protein	Q6JIG3	Burkholderia_virus	2.7e-70	56.2
WP_155121857.1\|930296_930473_-	hypothetical protein	NA	NA	NA	NA
WP_069238792.1\|930469_931165_-	hypothetical protein	A0A1V1FD44	Vibrio_phage	3.8e-41	43.6
WP_034193061.1\|931165_931612_-	hypothetical protein	Q3HQZ3	Burkholderia_phage	5.1e-63	77.7
WP_155121858.1\|931743_931911_-	hypothetical protein	NA	NA	NA	NA
WP_069246224.1\|931912_932143_-	hypothetical protein	NA	NA	NA	NA
WP_131929090.1\|932369_932639_-	hypothetical protein	NA	NA	NA	NA
WP_081335133.1\|933084_933900_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_069239398.1\|934172_934676_+	hypothetical protein	NA	NA	NA	NA
WP_069238795.1\|934998_935265_+	acyl carrier protein	A0A1P8VVJ5	Erythrobacter_phage	2.2e-05	37.9
WP_069238798.1\|938612_939143_+	hypothetical protein	NA	NA	NA	NA
WP_155121859.1\|939163_939403_-	hypothetical protein	NA	NA	NA	NA
WP_059723449.1\|939438_940146_+	hypothetical protein	A0A0U1SZL2	Pseudomonas_phage	7.1e-35	44.3
WP_155121860.1\|940058_940391_+	DUF4224 domain-containing protein	NA	NA	NA	NA
WP_069238800.1\|940387_941509_+	hypothetical protein	NA	NA	NA	NA
WP_080484227.1\|941787_942807_-\|tRNA	tRNA dihydrouridine(20/20a) synthase DusA	NA	NA	NA	NA
WP_069238801.1\|942895_943150_-	hypothetical protein	NA	NA	NA	NA
WP_010091415.1\|943193_943391_-	hypothetical protein	NA	NA	NA	NA
WP_006400187.1\|943530_943746_-	transporter	NA	NA	NA	NA
WP_069238802.1\|943801_944758_-	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	3.0e-28	37.0
WP_060001454.1\|944754_945564_-	aliphatic sulfonate ABC transporter permease SsuC	NA	NA	NA	NA
WP_069239399.1\|947081_947510_+	hypothetical protein	NA	NA	NA	NA
WP_069238803.1\|947629_948772_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_010092483.1\|948801_949140_-	multidrug efflux SMR transporter	NA	NA	NA	NA
WP_060237339.1\|949143_949641_-	heme-degrading domain-containing protein	NA	NA	NA	NA
WP_010092485.1\|950075_950621_+	NUDIX hydrolase	NA	NA	NA	NA
WP_010092486.1\|950630_951395_+\|tRNA	leucyl/phenylalanyl-tRNA--protein transferase	NA	NA	NA	NA

DBSCAN-SWA_2

1775491 : 1784515

unidentified_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060236159.1\|1775491_1777012_+	polynucleotide adenylyltransferase PcnB	H7BUW3	unidentified_phage	2.5e-24	33.3
WP_060236161.1\|1777045_1777591_+	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_060236163.1\|1777587_1778274_+	deoxynucleoside kinase	A0A0M3UL55	Enterococcus_phage	8.8e-06	23.7
WP_042583171.1\|1778315_1779131_+	3-methyl-2-oxobutanoate hydroxymethyltransferase	A0A0N7HVJ8	Ostreococcus_lucimarinus_virus	2.8e-35	30.5
WP_069239021.1\|1779275_1781171_-	aminodeoxychorismate synthase component I	S4VT78	Pandoravirus	3.2e-58	36.6
WP_010091447.1\|1781175_1782309_-	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	1.1e-24	38.2
WP_069239022.1\|1782565_1784515_-	molecular chaperone DnaK	A0A1V0SH73	Hokovirus	1.1e-146	50.5

DBSCAN-SWA_3

2026294 : 2086857

Acinetobacter_phage(28.57%)

transposase,plate,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060232647.1\|2026294_2027593_+\|tRNA	glutamyl-tRNA reductase	NA	NA	NA	NA
WP_059477809.1\|2027674_2028757_+	peptide chain release factor 1	A0A0S4KWG0	Pseudomonas_phage	8.7e-08	44.8
WP_060232650.1\|2028767_2029610_+	peptide chain release factor N(5)-glutamine methyltransferase	NA	NA	NA	NA
WP_010092833.1\|2029687_2029999_+	Grx4 family monothiol glutaredoxin	NA	NA	NA	NA
WP_060232652.1\|2030012_2030609_+	UbiX family flavin prenyltransferase	NA	NA	NA	NA
WP_060232655.1\|2030742_2031534_+	dioxygenase	NA	NA	NA	NA
WP_060232658.1\|2031643_2033242_-	APC family permease	NA	NA	NA	NA
WP_006400508.1\|2033664_2033868_+	cold-shock protein	A0A2H4N7Y6	Lake_Baikal_phage	1.4e-20	71.6
WP_060232661.1\|2033941_2035192_-	Hsp70 family protein	NA	NA	NA	NA
WP_042583007.1\|2035472_2036078_-	nitroreductase family protein	NA	NA	NA	NA
WP_010092839.1\|2036224_2037508_-	MFS transporter	NA	NA	NA	NA
WP_059931714.1\|2037728_2038349_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_060232664.1\|2038434_2039016_+	DUF1415 domain-containing protein	NA	NA	NA	NA
WP_059555435.1\|2039064_2039943_-	methyltransferase	NA	NA	NA	NA
WP_060232667.1\|2040035_2041169_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_069239066.1\|2041267_2041762_-	Water stress and hypersensitive response domain-containing protein	NA	NA	NA	NA
WP_069239067.1\|2042405_2044571_+	peptidase M1	A0A0P0IY26	Acinetobacter_phage	8.6e-47	25.7
WP_029226619.1\|2044687_2045704_-	transporter	NA	NA	NA	NA
WP_060232672.1\|2045902_2046874_-	hypothetical protein	NA	NA	NA	NA
WP_060232674.1\|2046997_2047843_+	M15 family metallopeptidase	NA	NA	NA	NA
WP_069239068.1\|2048145_2052060_+	type VI secretion system membrane subunit TssM	NA	NA	NA	NA
WP_010092853.1\|2052056_2053049_+	type VI secretion system-associated protein TagF	NA	NA	NA	NA
WP_088508897.1\|2053098_2054001_+	OmpA family protein	NA	NA	NA	NA
WP_045578564.1\|2054142_2054718_+	hypothetical protein	NA	NA	NA	NA
WP_069239069.1\|2054917_2056039_-	type VI secretion system protein TssA	NA	NA	NA	NA
WP_069239070.1\|2056094_2058770_-	type VI secretion system ATPase TssH	A0A223W0B1	Agrobacterium_phage	6.5e-89	31.7
WP_069239071.1\|2058808_2059909_-\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_010096523.1\|2059872_2061708_-\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_010096524.1\|2061773_2062259_-\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA
WP_010096526.1\|2062321_2062825_-	type VI secretion system tube protein Hcp	NA	NA	NA	NA
WP_010096528.1\|2062893_2064384_-	type VI secretion system contractile sheath large subunit	NA	NA	NA	NA
WP_060232690.1\|2064399_2064915_-	type VI secretion system contractile sheath small subunit	NA	NA	NA	NA
WP_069239072.1\|2064967_2065600_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_010099666.1\|2065976_2066588_+	type VI secretion system lipoprotein TssJ	NA	NA	NA	NA
WP_010099665.1\|2066690_2068037_+\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_069239073.1\|2068033_2068813_+	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_069239074.1\|2068905_2069223_-	hypothetical protein	NA	NA	NA	NA
WP_059606722.1\|2069956_2071192_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011883097.1\|2072544_2072874_-	hypothetical protein	NA	NA	NA	NA
WP_059460809.1\|2073414_2073840_-	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_080484274.1\|2073836_2078456_-	sugar-binding protein	A0A2H4JFP5	uncultured_Caudovirales_phage	7.4e-40	43.5
WP_069239076.1\|2078506_2081686_-	type VI secretion system tip protein VgrG	A0A2H4JCD4	uncultured_Caudovirales_phage	2.4e-61	27.0
WP_124259952.1\|2081684_2081975_+	hypothetical protein	NA	NA	NA	NA
WP_045566772.1\|2082000_2082801_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_155121888.1\|2083138_2083825_+	hypothetical protein	NA	NA	NA	NA
WP_069239078.1\|2084660_2085011_-	methylmalonyl-CoA epimerase	NA	NA	NA	NA
WP_155121863.1\|2085682_2086857_-\|transposase	IS3-like element ISBvi4 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.9e-75	48.9

DBSCAN-SWA_4

2863522 : 2907213

Acinetobacter_phage(15.38%)

transposase,integrase,protease,tRNA

attL 2883821:2883837|attR 2920925:2920941

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010090652.1\|2863522_2864125_-\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_060235991.1\|2864235_2864841_-	50S ribosomal protein L25/general stress protein Ctc	NA	NA	NA	NA
WP_059888343.1\|2865002_2865965_-	ribose-phosphate pyrophosphokinase	A0A2K9L2G2	Tupanvirus	5.3e-41	34.6
WP_060235993.1\|2866138_2867020_-	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	NA	NA	NA	NA
WP_060235995.1\|2867051_2867669_-	lipoprotein localization protein LolB	NA	NA	NA	NA
WP_069239270.1\|2869587_2870421_+	bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase	NA	NA	NA	NA
WP_060235999.1\|2870446_2871553_+	A/G-specific adenine glycosylase	NA	NA	NA	NA
WP_069239271.1\|2871580_2872222_-\|protease	ATP-dependent protease	NA	NA	NA	NA
WP_010090663.1\|2872248_2873157_-	RNase adapter RapZ	A0A1P8D5W0	Corynebacterium_phage	5.2e-06	32.5
WP_010090664.1\|2873241_2874210_-	HPr kinase/phosphorylase	NA	NA	NA	NA
WP_029226338.1\|2874346_2874859_-	PTS sugar transporter subunit IIA	NA	NA	NA	NA
WP_010090666.1\|2875053_2875422_-	ribosome-associated translation inhibitor RaiA	NA	NA	NA	NA
WP_060236000.1\|2875580_2877086_-	RNA polymerase factor sigma-54	NA	NA	NA	NA
WP_010090668.1\|2877251_2878028_-	LPS export ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	1.3e-18	30.1
WP_060236002.1\|2878024_2878690_-	lipopolysaccharide transport periplasmic protein LptA	NA	NA	NA	NA
WP_010090670.1\|2878710_2879325_-	LPS export ABC transporter periplasmic protein LptC	NA	NA	NA	NA
WP_042586336.1\|2879328_2879865_-	HAD family hydrolase	E3T535	Cafeteria_roenbergensis_virus	1.2e-10	28.7
WP_010090672.1\|2879864_2880848_-	KpsF/GutQ family sugar-phosphate isomerase	A0A2P0VNK5	Tetraselmis_virus	5.8e-43	37.5
WP_060236055.1\|2880974_2882981_+	potassium transporter	NA	NA	NA	NA
WP_010090674.1\|2883057_2883624_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	1.5e-27	41.1
WP_060236004.1\|2883650_2884265_+	LysE family translocator	NA	NA	NA	NA
2883821:2883837	attL	NA	NA	NA	NA
WP_069239272.1\|2884270_2885128_+	DUF4743 domain-containing protein	NA	NA	NA	NA
WP_060236007.1\|2885203_2886088_+	formyltetrahydrofolate deformylase	M4QRX9	Synechococcus_phage	2.8e-12	33.9
WP_155121911.1\|2886189_2887224_-	hypothetical protein	NA	NA	NA	NA
WP_060236015.1\|2887522_2890408_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	1.8e-302	54.4
WP_033354983.1\|2890604_2891792_+	MFS transporter	NA	NA	NA	NA
WP_069239274.1\|2891894_2892446_+	single-stranded DNA-binding protein	C5IHK5	Burkholderia_virus	4.7e-50	70.5
WP_069239275.1\|2892702_2893902_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_080484308.1\|2893898_2895521_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_069239276.1\|2895843_2897517_+\|integrase	integrase	NA	NA	NA	NA
WP_155121863.1\|2897713_2898888_-\|transposase	IS3-like element ISBvi4 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.9e-75	48.9
WP_069239277.1\|2899273_2899564_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_069239278.1\|2900854_2901160_+	helix-turn-helix transcriptional regulator	E5E3S9	Burkholderia_phage	6.4e-17	46.9
WP_080484309.1\|2901140_2902127_+	RNA-directed DNA polymerase	E5E3S8	Burkholderia_phage	5.4e-41	37.2
WP_069239279.1\|2902271_2903342_+	hypothetical protein	NA	NA	NA	NA
WP_155121863.1\|2906038_2907213_-\|transposase	IS3-like element ISBvi4 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.9e-75	48.9
2920925:2920941	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP013422

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013422_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013422_1

2029084-2029305

Orphan

Consensus_repeat	Method
GCCTGCGCCGCCGCCGAGCGCGCCGCCGAT	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP013422_1

>merge|NZ_CP013422|1|2029084-2029305|CRISPRCasFinder
GCCCGCGCCGCCGCCGACGGCCGCGCCGAGGAGGCCGCCCGTGCGGCCGCCCATCGCGTTGCCCGCCGCGGTGCCTGCGCCGCCGCCGAGCGCGCCGCCGATGATCGCGCCGGTGCGCTCGCGACGGTTCGACGTGACCGCGCCGCCTGCGCCGCCGCCGATCGCGCCGCCGATCACCGAGCCGGTGCTGCCGCCGACGGCGCCGCCGACTGCCGCGCCGGC

>NZ_CP013422|1|1|2029084-2029305|CRISPRCasFinder
GCCCGCGCCGCCGCCGACGGCCGCGCCGAG	GAGGCCGCCCGTGCGGCCGCCCATCGCGTTGCCCGCCGCGGT
GCCTGCGCCGCCGCCGAGCGCGCCGCCGAT	GATCGCGCCGGTGCGCTCGCGACGGTTCGACGTGACCGCGCC
GCCTGCGCCGCCGCCGATCGCGCCGCCGAT	CACCGAGCCGGTGCTGCC
GCCGACGGCGCCGCCGACTGCCGCGCCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013422.1\|WP_042584887.1\|2020176_2021292_+\|succinylglutamate-desuccinylase/aspartoacylase-family-protein	unknown	unknown	gnl\|CDD\|349468
NZ_CP013422.1\|WP_069240536.1\|2037392_2037869_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176904
NZ_CP013422.1\|WP_069240669.1\|2024224_2024602_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013422.1\|WP_010090100.1\|2023874_2024135_+\|DUF2866-domain-containing-protein	unknown	unknown	gnl\|CDD\|378547
NZ_CP013422.1\|WP_045577637.1\|2035534_2036320_-\|YhfC-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|337619
NZ_CP013422.1\|WP_034193383.1\|2034843_2035422_-\|membrane-protein	unknown	unknown	unknown
NZ_CP013422.1\|WP_069240530.1\|2030045_2030234_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013422.1\|WP_069240526.1\|2024673_2024901_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013422.1\|WP_069240528.1\|2027542_2028379_-\|(S)-ureidoglycine-aminohydrolase	unknown	unknown	gnl\|CDD\|183011
NZ_CP013422.1\|WP_069240533.1\|2032619_2033243_-\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|198289
NZ_CP013422.1\|WP_069240527.1\|2025448_2026060_-\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NZ_CP013422.1\|WP_059904680.1\|2021386_2022196_-\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP013422.1\|WP_069240537.1\|2038005_2038644_+\|2-hydroxychromene-2-carboxylate-isomerase	unknown	unknown	gnl\|CDD\|239320
NZ_CP013422.1\|WP_069240525.1\|2022512_2023661_+\|porin	unknown	unknown	gnl\|CDD\|238208
NZ_CP013422.1\|WP_060044260.1\|2026070_2026442_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013422.1\|WP_069240532.1\|2031160_2032567_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|224594
NZ_CP013422.1\|WP_069240535.1\|2036377_2036911_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP013422.1\|WP_069240531.1\|2030488_2030908_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NZ_CP013422.1\|WP_069240534.1\|2033555_2034758_+\|trans-2-enoyl-CoA-reductase-family-protein	unknown	unknown	gnl\|CDD\|237460
NZ_CP013422.1\|WP_059623687.1\|2026660_2027464_+\|3'-kinase	unknown	unknown	gnl\|CDD\|226100

Protein	Function_ID	Function_description	E-value
NZ_CP013422.1\|WP_042584887.1\|2020176_2021292_+\|succinylglutamate-desuccinylase/aspartoacylase-family-protein	gnl\|CDD\|349468	cd06250, M14_PaAOTO_like, Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO. An uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the the M14 family of metallocarboxypeptidases. This subgroup includes Pseudomonas aeruginosa AotO and related proteins. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD. The gene encoding P. aeruginosa AotO was characterized as part of an operon encoding an arginine and ornithine transport system, however it is not essential for arginine and ornithine uptake.	1.17963e-131
NZ_CP013422.1\|WP_069240536.1\|2037392_2037869_+\|SRPBCC-family-protein	gnl\|CDD\|176904	cd08895, SRPBCC_CalC_Aha1-like_2, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	9.57156e-70
NZ_CP013422.1\|WP_010090100.1\|2023874_2024135_+\|DUF2866-domain-containing-protein	gnl\|CDD\|378547	pfam11065, DUF2866, Protein of unknown function (DUF2866). This bacterial family of proteins have no known function.	3.39767e-26
NZ_CP013422.1\|WP_069240535.1\|2036377_2036911_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	9.75001e-09
NZ_CP013422.1\|WP_069240528.1\|2027542_2028379_-\|(S)-ureidoglycine-aminohydrolase	gnl\|CDD\|183011	PRK11171, PRK11171, (S)-ureidoglycine aminohydrolase.	0
NZ_CP013422.1\|WP_045577637.1\|2035534_2036320_-\|YhfC-family-intramembrane-metalloprotease	gnl\|CDD\|337619	pfam10086, DUF2324, Putative membrane peptidase family (DUF2324). This domain, found in various hypothetical bacterial proteins, has no known function. This family appears to be related to the prenyl protease 2 family pfam02517, suggesting this family may be peptidases.	1.49399e-32
NZ_CP013422.1\|WP_069240527.1\|2025448_2026060_-\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	5.6565e-63
NZ_CP013422.1\|WP_059904680.1\|2021386_2022196_-\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	3.57455e-120
NZ_CP013422.1\|WP_069240537.1\|2038005_2038644_+\|2-hydroxychromene-2-carboxylate-isomerase	gnl\|CDD\|239320	cd03022, DsbA_HCCA_Iso, DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-dihydroxynapthalene by a dioxygenase, into cis-o-hydroxybenzylidenepyruvate (cHBPA). This is the fourth reaction in a six-step pathway that converts napthalene into salicylate. HCCA isomerase is unique to bacteria that degrade polycyclic aromatic compounds. It is closely related to the eukaryotic protein, GSH transferase kappa (GSTK).	8.66347e-55
NZ_CP013422.1\|WP_069240525.1\|2022512_2023661_+\|porin	gnl\|CDD\|238208	cd00342, gram_neg_porins, Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers are stabilized by hytrophillic clamping of Loop L2. Loop 3 bends into the pore, creating an elliptical constriction of about 7 x 11A, large enough to allow passage of a glucose molecule without steric hindrance. Removal of the C-terminal residue (usuallly F) destabilizes the trimer and removal of the 16th beta-sheet abolishes trimerization. Unlike typical membrane proteins, porins lack long hydrophobic stretches. Short turns are found at the smooth, periplasmic end, longer irregular loops are found at the rough, extracellular end. C-terminal residue forms salt bridge with N-terminus.	3.87094e-84
NZ_CP013422.1\|WP_069240533.1\|2032619_2033243_-\|glutathione-S-transferase	gnl\|CDD\|198289	cd03180, GST_C_2, C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, unknown subfamily 2; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain.	2.69188e-49
NZ_CP013422.1\|WP_069240532.1\|2031160_2032567_+\|serine-hydrolase	gnl\|CDD\|224594	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms].	6.40938e-40
NZ_CP013422.1\|WP_069240531.1\|2030488_2030908_-\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	8.52632e-48
NZ_CP013422.1\|WP_069240534.1\|2033555_2034758_+\|trans-2-enoyl-CoA-reductase-family-protein	gnl\|CDD\|237460	PRK13656, PRK13656, enoyl-[acyl-carrier-protein] reductase FabV.	0
NZ_CP013422.1\|WP_059623687.1\|2026660_2027464_+\|3'-kinase	gnl\|CDD\|226100	COG3570, StrB, Streptomycin 6-kinase [Defense mechanisms].	1.03281e-84

>NZ_CP013422.1|WP_069240528.1|2027542_2028379_-|(S)-ureidoglycine-aminohydrolase
MSKTTYYAPHGGHPPQTDLLTDRAMFTEAYAVIPKGVMRDIVTSWLPFWANTRLWVIARPLSGFAETFSQYIVEVNPGGGSDKPEQDKEAEAVLFVVEGEVELTLQGSKHVLKPGGYAFIPPGANWTLHNVSDAAARFHWIRKRYQAVDGIALPEAFVTNEQDVEPIPMPGTDGAWVTTRFVDMSDMRHDMHVNIVTFQPGGVIPFAETHVMEHGLYVLEGKAVYRLNQDWVEVEAGDFMWLRAFCPQACYSGGPGRFRYLLYKDVNRHMNLTLNPAR
>NZ_CP013422.1|WP_059623687.1|2026660_2027464_+|3'-kinase
MFDTYLRRWDLVPDGGPILSASGGVLPVTRHAQPAMLKVATCDEERRGNALMTWWNGNGAARVWLHDRDAVLLERACATPTLGELSAAGHDDDAIRIACDAVARLHAHRAPQPPATVPLRDWFHALLAHAHDDGHDEVLRVSAEIAQRLLAAPVDEAVLHGDIHHGNVLNFGDRGWLAIDPKGLHGERAFDYANLFCNPAHDLAVDRARFERRVALVADAAQIDRQRLLQWIVAWAGLSAVWSIDDGRTADTPLQVAMLAAGSLGLK
>NZ_CP013422.1|WP_060044260.1|2026070_2026442_-|hypothetical-protein
MIHRTADPSSRPPVCAALPRRCVRRIPLAVTVSPDYMKTTDDGTLSVAVKPPRMARVDRRDFAHARSARSTRSDDFAPLIRRVVALGASGTIERHAQRKPATPLPAIDAAGRARVRGLFRIES
>NZ_CP013422.1|WP_069240527.1|2025448_2026060_-|trimeric-intracellular-cation-channel-family-protein
MHTLYLIAIVAEAMSGALMGMRRGMDRFGLALVGAVTALGGGTVRDVLLGHYPLGWIAHPEYLVITLAAATFASWAARRLARMKTLFVTVDAVGLAAFTIIGCDIGATTGSAPVIVVLAGAITGVCGGMLRDLLCNEMPLILREELYASVAFCTGALYVGMQYLGIGADVATVVALAAGFAMRMLAVRLGWKLRTFAVADVER
>NZ_CP013422.1|WP_069240526.1|2024673_2024901_+|hypothetical-protein
MNAQSLSGMLRAQELLLVSMIRALPPDTRSAVVDLYAEQLAFAEQGGFEGHGDRATHDAFIAHARNLLIRIESLA
>NZ_CP013422.1|WP_069240669.1|2024224_2024602_+|hypothetical-protein
MENAFNERGVTVTRNGLSAAGQVFPLRDIRRVDVVKIPKNKLVPSLISLIGAAVAGGLFGSTAALVVGVMLVVVGYLAWTTQDVTYRLIVEMPDGKREALSSVDVEFVERVARTVRDARAATAAG
>NZ_CP013422.1|WP_010090100.1|2023874_2024135_+|DUF2866-domain-containing-protein
MIEDTVFSHLHAILTREHSLPVQSCRVSVEMQRPWGRPYRLVEWTMHLDAPARRQVVPAESTDAEIAEVVASHVPGRLYGDGRLQF
>NZ_CP013422.1|WP_069240525.1|2022512_2023661_+|porin
MNKKLLTAAILAATAGAAQAQSSVTLYGLIDAGISFANHSKTATGNDRLFKYDDGVAQGSRWGLRGTEDLGGGLKAIFVLENGFNSGTGALGQGGAIFGRQAYVGLSTAQYGTVTFGRQYSFSTDILGANYSTGGNTVAGNYAYHVNDVDQLTSSRINNAVKFQSANYAGFTFGALYGFSNSTDFAGSAGTGTPATGGSSRAYSFGLNYANGPFSLGAAYTDIRFPGQSAPAFSTTIANLALSNIRDLRSYGVGGRYIWGPATAWLLWTRTQFTPVSGSGSFYNAYEAGVKYAITPALSAAAGYTYTNATLPGQSAHWNQGDLALDYALSKRTDVYGLVIYQDASGDGAQAAIGSSTSSYFGTSGTNSQNQLAVRVGIRHKF
>NZ_CP013422.1|WP_059904680.1|2021386_2022196_-|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MRRSNWLTGFAALGAALMFAAPGAHADPQALKIGTMSGPDADIWAVVTKVAARDGLAIKVIEFNDYVQPNAALDAGDLEANGFQHQPFLDSQIKQRGYKIVSVGLTYTMPMAFYSKKIKSIKDLPVGAKVGIQNDPSNGNRALLLLQKYGVIKLKPGAGTNGVNATPLDVAENPKKIKLVELDAAQLPRALPDLDAASINTDYAVKAGLTPVKDAIAIEDLKGPYANLIAVRAQDRDKPWVKKLVAAYESNDVRRFIETKFGGAIVPAF
>NZ_CP013422.1|WP_042584887.1|2020176_2021292_+|succinylglutamate-desuccinylase/aspartoacylase-family-protein
MQTQTHPLISPAVGTERHITSFHYGPRGGTKIYIQSSLHADELPGMLVAALLRRKIAALETAGKLRGEIVIVPVPNPIGLAQHVFGDHLGRFELGSMQNFNRNFYDLAALVLPRVEARLTKDGARNVAAVRAAMREALDEQAPRTELESQRLALQKLSYDADIVLDLHCDNDAVMHLYTNPDLWEDVEPLARYLDAQASLLALNSVGNPFDEIHSFCWSDLRERFGDRFPIPNGAISVTVELRSERDVSYEFAEKDAQAIVEYLTARGVIEGTPAPLPPLAYPATPLAGTDPLVAPVSGVIVFRTPVGAWIEVGQEVADIVDPLTDRVVTLKSSVSGVLYARQVVRFATAGMEVARIAGATPIRTGSLLSA
>NZ_CP013422.1|WP_069240530.1|2030045_2030234_-|hypothetical-protein
MYKVLISFALIAGLSGCYVAPPYGYAPAPAYGYAPAPAYYGYAPAYYAPPVSVGIGGHFRIR
>NZ_CP013422.1|WP_069240531.1|2030488_2030908_-|HIT-family-protein
MSYDTNNPFAKILRGDLPCVKVAEDDATLVIMDLMPQADGHVLVIPKEPAAEIFDLSADAAAACIRMTQRVAAAVRDALRPDGMFIGQFNGRAAGQTVAHVHFHVIPRWEGVELRMHARDVADAATLEALAQRIRARFV
>NZ_CP013422.1|WP_069240532.1|2031160_2032567_+|serine-hydrolase
MTLPFKSLILRGAAVAVAVTLGYAGYTLSRLAPIATGYAAKTLCSGVFVSGRPAASVIDVDIMAGVHPLLKLVRPSLDPEHRRAVATFAGFARREADFRPGLGCTLALGPAHDVLPAALPPVADPPHAVAVAAPAALSGIDTGKLQHALDRAFDEPDPARPRRTRAVVVLHRGRVIAERYAPGFSADMPLPGWSMTKSVTAALIGMLVAQHKLSPDASALLPEWRDAGDPRARITLDELLRMTSGLRFNEDYDDPLSDVAVMLFTQPDTARFASAMPLAAPPGTRWHYSSGTSAILARVMRDAMGGTETDYLAFPQHALFAPLGMRNAFFEPDASGTLASASFMYASARDWAQFGQLLLQDGVWDGKRLLPEGWVRYMARATPQAPRREFGAHLWVKVPEPFNDPDPHAPALPADAFHAVGHEGQFVSVVPSRQLVIVRLGVSRPEAAWNHEAFLARVLDAVPAAAAR
>NZ_CP013422.1|WP_069240533.1|2032619_2033243_-|glutathione-S-transferase
MLHILGKIPSINVRKVLWLCAELDLPFEREDWGAGFRSTDDPAYLALNPHGLVPVIKDGDFVLWESNTIIRYLANRYGGESLYPAEPQARARIDQWLDWQASDLNRSWVFAFQGLVRKSPDHQDPDGIAKSIADWTKHMRVLNAQLDATGAFVAGDRFTLADIPIGLSVNRWLGTPFERPDLPAVQRYVERLATREGFKKYAGSANP
>NZ_CP013422.1|WP_069240534.1|2033555_2034758_+|trans-2-enoyl-CoA-reductase-family-protein
MIIKPRVRGFICVTTHPVGCEANVKEQIDYVTSHGPIAGGPKKVLVIGASTGYGLAARITAAFGSGADTLGVFFERAGSETKPGTAGWYNSAAFEKFAAAKGLYARSINGDAFSDAVKQVTIDTIKRDLGKVDLVVYSLAAPRRTHPKTGETISSTLKPIGKSVSFRGLDTDKEVIRETVLEPATQEEIDGTVAVMGGEDWQMWIDALHDAGVLADGAKTTAFTYLGEQITHDIYWNGSIGAAKKDLDKKVLAIRDTLSPTGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKEQGTHEGCIEQVYGLLKDSLYGATPHVDDEGRLRADYKELDPQVQAKVAALWDQVTNENLYELTDFAGYKTEFLRLFGFAIAGVDYEADVNPDVQIPGIIDTTA
>NZ_CP013422.1|WP_034193383.1|2034843_2035422_-|membrane-protein
MKRTPIAVALAGLLVALPVAAWALVKPLRVIAPALVPGVSCAGADICIDDPAKLGEARQLYRDGYARAAAVTGAFRSAPRVVFCSTRACADRFGLGERAALTLGDFGVVFAPRGWQTYFVAHELIHHRQAEALGNLAVATKPRWLIEGMAYSLSGDPRHPLTEPFESWRTRFDAWHAALGRQPLWDAAAAVQ
>NZ_CP013422.1|WP_045577637.1|2035534_2036320_-|YhfC-family-intramembrane-metalloprotease
MHIIDPVLLFATFCAGVTALAGPPLLALVWRHRAGVPWRAFFCGMLIFFVFQPVLRLSWQIPLFRWLGDDPRWHMPMLVFAALTAALFEECGRWVAFRYLLAGQRDPRTAVMYGLGHGGLEAMLLVGVGFVALCGGYLLARAGLVTSAGVQTLIASQFAGMTLASPFLAVLERVSAVAAHVGMSLMVMQTFVRGTKRWLLGAIAVHFAIDLVVVLLSRYWHLDSTLLEALLLGCSVAILWLGIRSSRWGAAADGLRGGQAT
>NZ_CP013422.1|WP_069240535.1|2036377_2036911_-|GNAT-family-N-acetyltransferase
MTEPVTVRRVDAREAHACADALADVLIDCVEGGASVSFMLPIARATAVAFWKQVAEGVARGERILLVAEDAAARIVGTVQIVTAQAENQPHRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKAVLVLDTVTGSDAARLYERAGWQRVGDVPNYALMPDGTPCATTYFHKQLVS
>NZ_CP013422.1|WP_069240536.1|2037392_2037869_+|SRPBCC-family-protein
MLHMHTHSTRVSRHLNAPRGRVYRALLDPHAIEQWKAPDGMTCRVDAFDAREGGALRVSLSYDAPSDGTGKTTAHTDTYHGRFVTLVPNELVVEIDAFETDDPALRGAMTITITLSDDAGSTRIDAVHDGLPPGVPAADNETGWRMALAKLAALVEHG
>NZ_CP013422.1|WP_069240537.1|2038005_2038644_+|2-hydroxychromene-2-carboxylate-isomerase
MNATRTATWYFDFVSPFAYLQLERFDTLPPDIAFEPKPIVLGALLAHWGQKAPAEIAAKRVFTYRHAQYRADKLGIAFRMPPAHPFNPIRPLRLAIAMGGSLDAIRRIFRHIWRDGHDVASPEGFAALCDAVGFPEGVTAVDAQEVKDALRAHTDHAIAHGVFGVPTFELDGDLFWGEDATAMFVDCVASRAWLDSPEVRRISALPDGIRRG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP013421

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013421_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013421_1

135533-135620

Orphan

Consensus_repeat	Method
GCCCGACCTGCGACGGCGATGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013421_1

>merge|NZ_CP013421|1|135533-135620|CRISPRCasFinder
GCCCGACCTGCGACGGCGATGCGGAGCAATTCATGGTGCTGAGGGACTGACGTTGACCACGCGAAGCCCGACCCGCGACGGCGATGCG

>NZ_CP013421|1|1|135533-135620|CRISPRCasFinder
GCCCGACCTGCGACGGCGATGCG	GAGCAATTCATGGTGCTGAGGGACTGACGTTGACCACGCGAA
GCCCGACCCGCGACGGCGATGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013421.1\|WP_011880077.1\|141334_142411_+\|hydrogenase-expression/formation-protein-HypE	unknown	unknown	gnl\|CDD\|100033
NZ_CP013421.1\|WP_011880067.1\|133937_134471_+\|hydrogenase	unknown	unknown	gnl\|CDD\|239263
NZ_CP013421.1\|WP_045579643.1\|133590_133941_+\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	unknown	unknown	gnl\|CDD\|376549
NZ_CP013421.1\|WP_011880079.1\|144030_145068_+\|NADH-ubiquinone-oxidoreductase	unknown	unknown	gnl\|CDD\|224654
NZ_CP013421.1\|WP_011880073.1\|137747_138785_+\|hydrogenase-nickel-incorporation-protein-HypB	unknown	unknown	gnl\|CDD\|182479
NZ_CP013421.1\|WP_011880061.1\|127372_128440_-\|HoxN/HupN/NixA-family-nickel/cobalt-transporter	unknown	unknown	gnl\|CDD\|225911
NZ_CP013421.1\|WP_011880072.1\|137370_137718_+\|hydrogenase-maturation-nickel-metallochaperone-HypA	unknown	unknown	gnl\|CDD\|376468
NZ_CP013421.1\|WP_014725812.1\|132922_133600_+\|HyaD/HybD-family-hydrogenase-maturation-endopeptidase	unknown	unknown	gnl\|CDD\|129246
NZ_CP013421.1\|WP_011880075.1\|139947_140205_+\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	unknown	unknown	gnl\|CDD\|376549
NZ_CP013421.1\|WP_059475439.1\|142531_144034_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP013421.1\|WP_011880076.1\|140201_141338_+\|hydrogenase-formation-protein-HypD	unknown	unknown	gnl\|CDD\|237892
NZ_CP013421.1\|WP_080484346.1\|124884_125367_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|379098
NZ_CP013421.1\|WP_011880080.1\|145076_146534_+\|nickel-dependent-hydrogenase-large-subunit	unknown	unknown	gnl\|CDD\|380187
NZ_CP013421.1\|WP_034192889.1\|129098_130172_+\|hydrogenase-small-subunit	unknown	unknown	gnl\|CDD\|224654
NZ_CP013421.1\|WP_046424893.1\|125730_127341_-\|carbamoyltransferase	unknown	unknown	gnl\|CDD\|225103
NZ_CP013421.1\|WP_011880063.1\|130229_132086_+\|nickel-dependent-hydrogenase-large-subunit	unknown	unknown	gnl\|CDD\|366057
NZ_CP013421.1\|WP_011880068.1\|134488_135352_+\|hydrogenase-expression/formation-protein	unknown	unknown	gnl\|CDD\|377409
NZ_CP013421.1\|WP_011880071.1\|136129_137383_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225798
NZ_CP013421.1\|WP_011880074.1\|138781_139957_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223146
NZ_CP013421.1\|WP_011880064.1\|132204_132915_+\|Ni/Fe-hydrogenase,-b-type-cytochrome-subunit	unknown	unknown	gnl\|CDD\|273985

Protein	Function_ID	Function_description	E-value
NZ_CP013421.1\|WP_011880077.1\|141334_142411_+\|hydrogenase-expression/formation-protein-HypE	gnl\|CDD\|100033	cd02197, HypE, HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the ATP-binding domains of the AIR synthases, selenophosphate synthetase (SelD), and FGAM synthase and is thought to bind ATP.	9.76796e-174
NZ_CP013421.1\|WP_011880067.1\|133937_134471_+\|hydrogenase	gnl\|CDD\|239263	cd02965, HyaE, HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the sole energy source. The E. coli HyaE protein is a chaperone that specifically interacts with the twin-arginine translocation (Tat) signal peptide of the [NiFe] hydrogenase-1 beta subunit precursor. Tat signal peptides target precursor proteins to the Tat protein export system, which facilitates the transport of fully folded proteins across the inner membrane. HyaE may be involved in regulating the traffic of [NiFe] hydrogenase-1 on the Tat transport pathway.	1.19404e-47
NZ_CP013421.1\|WP_045579643.1\|133590_133941_+\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	gnl\|CDD\|376549	pfam01455, HupF_HypC, HupF/HypC family.	7.79732e-22
NZ_CP013421.1\|WP_011880079.1\|144030_145068_+\|NADH-ubiquinone-oxidoreductase	gnl\|CDD\|224654	COG1740, HyaA, Ni,Fe-hydrogenase I small subunit [Energy production and conversion].	1.62496e-67
NZ_CP013421.1\|WP_011880073.1\|137747_138785_+\|hydrogenase-nickel-incorporation-protein-HypB	gnl\|CDD\|182479	PRK10463, PRK10463, hydrogenase nickel incorporation protein HypB; Provisional.	3.54357e-128
NZ_CP013421.1\|WP_011880061.1\|127372_128440_-\|HoxN/HupN/NixA-family-nickel/cobalt-transporter	gnl\|CDD\|225911	COG3376, HoxN, High-affinity nickel permease [Inorganic ion transport and metabolism].	1.0005e-127
NZ_CP013421.1\|WP_011880072.1\|137370_137718_+\|hydrogenase-maturation-nickel-metallochaperone-HypA	gnl\|CDD\|376468	pfam01155, HypA, Hydrogenase/urease nickel incorporation, metallochaperone, hypA. HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.	3.26172e-39
NZ_CP013421.1\|WP_014725812.1\|132922_133600_+\|HyaD/HybD-family-hydrogenase-maturation-endopeptidase	gnl\|CDD\|129246	TIGR00140, Hydrogenase_expression/formation_protein_HupD, hydrogenase expression/formation protein. valid names: hupD, hynC, hoxM. C at 64 and 67 are believed to be metal binding. Postulated to be involved in processing or hydrogenase. Superfamily suggests that it is a peptidase/protease. [Protein fate, Protein modification and repair].	4.13993e-68
NZ_CP013421.1\|WP_011880075.1\|139947_140205_+\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	gnl\|CDD\|376549	pfam01455, HupF_HypC, HupF/HypC family.	5.78658e-32
NZ_CP013421.1\|WP_059475439.1\|142531_144034_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.4706e-149
NZ_CP013421.1\|WP_011880076.1\|140201_141338_+\|hydrogenase-formation-protein-HypD	gnl\|CDD\|237892	PRK15062, PRK15062, hydrogenase isoenzymes formation protein HypD; Provisional.	0
NZ_CP013421.1\|WP_080484346.1\|124884_125367_-\|IS3-family-transposase	gnl\|CDD\|379098	pfam13276, HTH_21, HTH-like domain. This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.	2.59849e-05
NZ_CP013421.1\|WP_011880080.1\|145076_146534_+\|nickel-dependent-hydrogenase-large-subunit	gnl\|CDD\|380187	NF033181, NiFeSe_hydrog, nickel-dependent hydrogenase large subunit. Members of this family are the large subunit of the periplasmic nickel-dependent hydrogenase. Some members contain a selenocysteine residue.	5.6028e-128
NZ_CP013421.1\|WP_034192889.1\|129098_130172_+\|hydrogenase-small-subunit	gnl\|CDD\|224654	COG1740, HyaA, Ni,Fe-hydrogenase I small subunit [Energy production and conversion].	0
NZ_CP013421.1\|WP_046424893.1\|125730_127341_-\|carbamoyltransferase	gnl\|CDD\|225103	COG2192, COG2192, Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones].	4.22664e-133
NZ_CP013421.1\|WP_011880063.1\|130229_132086_+\|nickel-dependent-hydrogenase-large-subunit	gnl\|CDD\|366057	pfam00374, NiFeSe_Hases, Nickel-dependent hydrogenase.	0
NZ_CP013421.1\|WP_011880068.1\|134488_135352_+\|hydrogenase-expression/formation-protein	gnl\|CDD\|377409	pfam04809, HupH_C, HupH hydrogenase expression protein, C-terminal conserved region. This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown.	1.08896e-49
NZ_CP013421.1\|WP_011880071.1\|136129_137383_+\|hypothetical-protein	gnl\|CDD\|225798	COG3259, FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion].	8.21225e-05
NZ_CP013421.1\|WP_011880074.1\|138781_139957_+\|hypothetical-protein	gnl\|CDD\|223146	COG0068, HypF, Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones].	5.28621e-76
NZ_CP013421.1\|WP_011880064.1\|132204_132915_+\|Ni/Fe-hydrogenase,-b-type-cytochrome-subunit	gnl\|CDD\|273985	TIGR02125, CytB-hydogenase, Ni/Fe-hydrogenase, b-type cytochrome subunit. This model describes a family of cytochrome b proteins which appear to be specific for nickel-iron hydrogenase complexes. Every genome which contains a member of this family posesses a Ni/Fe hydrogenase according to Genome Properties (GenProp0177), and most are gene clustered with other hydrogenase components. Some Ni/Fe hydrogenase-containing species lack a member of this family but contain other CytB homologs (pfam01292) which may substitute for it.	6.27348e-76

>NZ_CP013421.1|WP_011880068.1|134488_135352_+|hydrogenase-expression/formation-protein
MQMKTFPVPVVPFGPGSQPEGDAVLDYMPMPQAMHTFVAPSLPERADARALDVVRGILLTVLDALDACRRGEQPAPIDLTACDADALRILNAVLGEGEVSARIDTADAGSVLIQETVFAGVWRIAEDGPAGRAERIEVGGAPAALAAAAHAAAAPELPVSDTHPSGVMNAPAILTEVRDQVARWRAGAAPHVINLTLLPLSSEDGAFIDAVLGGGPVSVLSRGYGNCRIASTGVVHCWRIAYFNSQDTLILNTIEITDLPEIVQAAPEDIDDSHERLAQLIDWVEEA
>NZ_CP013421.1|WP_011880067.1|133937_134471_+|hydrogenase
MSETSGSVPGATQADAPNVPNVPNAAAAGQDCPAVVQRLIEQAHATFVDEHTLDGWLADGGECVVLLMGDPVRFPESLDVAAVLPELAHVAAVRFGRALRLAVATRAGENAIARRFGSLRWPALLWLRDGQYVTVLSGMMDWDDYVKCVADALAGPTTRAPSIGIPVNVAGGSSGCH
>NZ_CP013421.1|WP_045579643.1|133590_133941_+|HypC/HybG/HupF-family-hydrogenase-formation-chaperone
MCIGLPMQVVEAQPGHAWCVGRGVRRRVDTALVGPCAPGDWLLVFLDAARERLDAARAAEIDATLALIESVMAGEGGAASPAAFALPSALGVDELNRLVGGPQRAAGSLAVPEESK
>NZ_CP013421.1|WP_014725812.1|132922_133600_+|HyaD/HybD-family-hydrogenase-maturation-endopeptidase
MDTSPQTIPSAQDGAAIVALGIGNVLWADEGFGVRCIEALQQRFECAPNVTLMDGGTQGLYLIQHVQAADFLLIFDAVDYGLAPGELKIVEDDEVPKFLGVRKMSLHQTGFQEVLMLAQLTGKYPRRVVLIGCQPEEIEDYGGSLRPCVKAALERALDAGVAYLREWGGAPLPRRTALRDDEAVTLHHLALARYEGERPSEADACRIGDERVLVRALAKEPPSCA
>NZ_CP013421.1|WP_011880064.1|132204_132915_+|Ni/Fe-hydrogenase,-b-type-cytochrome-subunit
MTMQTQSRRGRAPDTVPAAKAIYVYEAPVRIWHWMNAASIAVLSITGYLIGSPLATQPGEASAHFLMGYIRFAHFAAAYLFAVGLAGRAYWALVGNHHAREMFWVPVFTRDYWLDVFGMLRYYMFLGPCPRQYSGHNPLSRFAMFFVFLTVSLFMVVTGFALYGEGAQAGSWQQRTFGWIRPLLGQSQGVHTWHHLGMWAILLFVILHVYAAIREDIMGRQSVVGSMISGYRTFKD
>NZ_CP013421.1|WP_011880063.1|130229_132086_+|nickel-dependent-hydrogenase-large-subunit
MTAYSTQGFQLDNSGRRIVVDPVTRIEGHMRVEVNVDSNNVIRNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGCHALASVRAVEDALDIRIPPNAHLIREIMAKTLQVHDHAVHFYHLHALDWVDVVSALKADPKLTSELQQRVSPSHPMSSPGYFRDIQTRLRKFVESGQLGPFMNGYWGNPAYLLPPEANLMAVTHYLEALDLQKEWVKIHTIFGGKNPHPNYLVGGVPCAINIDGDLAAGAPINMERLNFVRSLIDQAETFCRNVYVPDLLAIGTIYKARGWLHGGGLAATNVMDYGTYPLVNYDPSTNQMPGGAILNGDWDNILPVDARDPEQVQEFVTHSWYQYPDNDRGLHPWDGMTEPHYELGPNTKGTRTAIESVDESAKYSWVKAPRWRGHAMEVGPLARYILGYAHAKQGNPHGARIKEQIDAALQSVNQDMPKLLGLPETTLGAKQLLPTTIGRTLARALEAQYCAEMMSDDWQRLVDNIRNGDTSTANVEKWDPSTWPAEAKGVGTVAAPRGALGHWIKIKDGRIENYQCVVPSTWNGGPRDAKGQIGAFEASLMNTPMANPEQPVEILRSLHSFDPCMACSTHVMSEDGAEMTTVTVR
>NZ_CP013421.1|WP_034192889.1|129098_130172_+|hydrogenase-small-subunit
METFYEVMRRQGISRRSFLKFCSLTATSLGLGPAFMPRIVEAMETKPRTPVLWLHGLECTCCSESFIRSAHPLAKDVVLSMISLDYDDLLMASAGHQAEAILEEVMTKYKGNYILAVEGNPPLNQDGMSCIIGGKPFVDQLRRVSKDAKAVISWGSCASWGCVQAAKPNPTQAVPIHKVITDKPIIKVPGCPPIAEVMTGVITYMLTFDRVPELDRQGRPKMFYSQRIHDKCYRRPHFDAGQFVEAWDDDAARRGYCLYKVGCKGPTTYNACSTVRWNGGTSFPIQAGHGCIGCSEDGFWDKGSFYDRLTHINQFGVEANADKIGGTAAVVLGAAAAAHAAASAIQRVSSKRDRDGR
>NZ_CP013421.1|WP_011880061.1|127372_128440_-|HoxN/HupN/NixA-family-nickel/cobalt-transporter
MTAPVPPGAGVRASGARGKLVLLLAALAAFNLAAWGWAVAVFGGQPTLMGACVLAYTFGLRHAVDADHIAAIDNVTRKLMHEGRRPLTVGLMFSLGHSTIVIVASAAIAAAAFGLRERLAAFHDIAGTIGTLVSTTFLLAIAVANLVTLHSVVRTLRRVKRGERYADAHADTALHHHGFLARLLRPVLRMVTKSWHMYVLGALFGLGFDTATEIGVLGISATSAAHGMSAWSIMVFPALFTASMSLVDTADSMLMLGVYGWAFREPVRKLYYNVGITALSAAVALLIGCVEGFALLGDTFGIRGAFRDVVDALNAHLGALGYAIVVLCAASWLVCAAIYRFRRGSFAPLAEHDHG
>NZ_CP013421.1|WP_046424893.1|125730_127341_-|carbamoyltransferase
MSHRIPPAPADGVLGVQTGPAPNTGAAWVATAAGARRIAHAGQERFDRIKQSRAYPAAAVDACRIALDLPADARPSLVACVDTGQAAPLPPYVDTVPQLRVEHALCHAAAAYYCSPFDEAAILVVDGHRREQGATPSSHSVWIGWNGRIEPVMRSASCGIGALYEAVTVAIGFGAHETGKTMGLAPYGDDAAAPDLGGRLDGLAVDYGARCDADGVRLFGLSPLAGATDDESLAARATLARAAQRECERAMLHLARAVREMTGMRRLCLAGEVSLNGRANDLVWRDAGFDAVFAGPAGADCGTSLGAALWGYHGVQGVPFRPGPVSPYGGRPYSDADVDAALAALPDRARYRDTRGTIDELAERTAALLAAGQCVALHAGRAEMGPRALGNRSLLMSPAHADARDRMNLRVKRREAFRPFAPCVPVEDAARYFELDTPSPYMLRICAVRPQWRARIAAITHVDGTARPQTVSPQDNPHLHRLLRAFERVAGIPVLLNTSFNVAGEPLVETPADALRGFARNDIDALWIGDRLLEKR
>NZ_CP013421.1|WP_080484346.1|124884_125367_-|IS3-family-transposase
METAVAGARCGCVRRSGPGIERIAGRCEDAACEDRPVDTGEPFFVRSARQGRTAERKAMIDRTHALPVSRQTRLVGIARSSVYYRPQPVSEVDRLLMRRIDEQHMEFPFSGARMLARLLRREGHEVGRRRVRTLMKRMGVEALCRDRKFCQLASVELLAE
>NZ_CP013421.1|WP_011880071.1|136129_137383_+|hypothetical-protein
MTGVASTSEDTSGFAALAGRYVVRPGRSPSIDGGRPPLAGLLLAGQPAALAAPRLSAVFSLCGRAHALCAELAVTAAGAYANAGGAAGDCGGKGDADGNVDRNGAGDDHDASRGEGERDGEDARSATLARETIAEHLRRIWLDWPARLVGGAPCALPDVRAAGTREWIERHVLGEPADGWLARWDQDPRACLSAWTARATSFPASLLLHCRTVADALRMPPRALRIDGADRARLRRIGAAIAGDPRFAQRPEQDGAPAETGVWTRCGDPHAAAYDSAWLRLGARVAELARLAAGGPAAFALRSGALALAPGEALAWCETARGVLIHWVRLVPGDAARVADYRVASPTEWNFHPDGTLAHALARVDVRPDGGGDAGLAARVGALMGAFDPCIAYALETAAPVRRDDDHTNGNRSTCMK
>NZ_CP013421.1|WP_011880072.1|137370_137718_+|hydrogenase-maturation-nickel-metallochaperone-HypA
MHEVSLAGGVLAAVEAAAARERFARVNVLRLEVGRLAGVEVDALRFALDAMAPGTCLAGARIEIAEPPGRAWCLNCHCDVPLAARGEPCGRCGGYWLQPNGGTELRIVDMLVDDA
>NZ_CP013421.1|WP_011880073.1|137747_138785_+|hydrogenase-nickel-incorporation-protein-HypB
MCVVCGCDSPDGAHLDRHDAHHAHHDAQAHVRADAASGDLHYGLGPAGVTVHGLDQGRTVRIEQDVLGENDRHAAHNRRHFAAHGVRALNLVSSPGSGKTTLLCATIAALRARAPTLPIAVIEGDQQTANDAERIRAAGAPAIQVNTGKGCHLDAAMVAAAYERLPLHAHGHDHGHAHGHGHEHHHHDHDHHHPHDAHASSERRGAAQQPDSVLFIENVGNLVCPALWDLGEDAKVAILSVTEGEDKPLKYPDMFAAARLMIVNKTDLLPYVQFDVERCIEYARRINPALDVICVSATTGDGIDAWLDWVLRTGDARGPLAARIGELEAELAALRAQQRRAGDAA
>NZ_CP013421.1|WP_011880074.1|138781_139957_+|hypothetical-protein
MTLRRERLPRAWGADTVLATGAWLKNAACVYVDGDVYWSPLHGDLDDPRHCVALEASVASLVDAARQAGRPVRAIAHDLHPDFHSSRLAVEWSERLGVPAIAVQHHHAHIGAVAAEHGLAEPVVGLALDGVGLGTDGAAWGGELLEVAPDGWRRLGHLTPLALPGGDVAAREPWRMAAAALHTLGRADEIEARLGGDVGTRAARTIGTMLARGLNCPPSTGAGRWFDAAAGLLGVCRHQCTEAEAAIALERHAADYLRDHPEPDTDGLWRIADDGELDLRPLLVRVLELADAGASAHGAALFHLALADALAAWAAAAAHGRAVLLGGGCFANRLLSARLRAALDARGVRSCAPSSVPCGDAGLALGQAWVAAHTLTSGAVRATSEGVSTCV
>NZ_CP013421.1|WP_011880075.1|139947_140205_+|HypC/HybG/HupF-family-hydrogenase-formation-chaperone
MCLAIPARVVELRDADMGVVDLGGVRKTISLALVPDARLGEYVIVHVGYALGRIDPDEAERTLALFGELAHAAGDGDVHPSGAPQ
>NZ_CP013421.1|WP_011880076.1|140201_141338_+|hydrogenase-formation-protein-HypD
MKYIDEFRDRALAERISARIQAEAQPGTRYHFMEFCGGHTHAISRYGVTDLLPDNVRMIHGPGCPVCVLPVGRIDLAVQLALERGVIVCTYGDTMRVPASGGMSLMRAKAHGADIRMVYSPLDALKIARLNPDREVVFFAIGFETTTPPTALIVRDAAAAGVDNFSVLCCHVLTPAAITHLLAAPAVAADAVPLDGFIGPAHVSIVIGSAPYEGFARDYRKPVVIAGFEPLDVMQAILMLIRQVNDGRAEVENEFSRAVTRAGNAAAQALMDDVFEARESFEWRGLGEVPASALRIRAKYARHDAEARYGLVYRPVADHRKCECGAILRGLKQPRDCSLFGTVCTPENPMGSCMVSSEGACAAHYSYGRFKDIPLVPA
>NZ_CP013421.1|WP_011880077.1|141334_142411_+|hydrogenase-expression/formation-protein-HypE
MSSTPTPRTKPAYVRPLNFRDGRIDMGHGAGGRASAQLIRELFVAAFDNEWLRQGNDQAAFAPPATAPGERVVMATDAHVVSPLFFPGGDIGSLAVHGTVNDVAMSGARPLYLAASFIIEEGFALADLKRIVESMANASRECGVPIVTGDTKVVERGKGDGVFITTTGVGVVPAGIRIDGALARPGDAVLLSGTIGEHGVAIMSTREALEFDVEISSDSAALHTLVASMLAAVPGVRVLRDPTRGGLATTLNEIASQSGVGMLIREDAIPVLPQVDAACELLGLDPLYVANEGKLVAVCAAEDAPALLAAMRAHPLGAHAVQIGEVTEDAHGFVQVETKFGGRRIADWLSGEQLPRIC
>NZ_CP013421.1|WP_059475439.1|142531_144034_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MSSPLPVHPSTDPEPDPAPLRRPPTVLVVDDELRAQETIRRVLDEEFEVLTASSADEARAILQQQPVAVILCDQRMPGRTGVEFLSEVRETWPDTVRIIVSGYTDSEDIVAGINQAGIHRFVLKPWMPDHLLHTVRQAAEAQSLQQDMHRLDLELRNSVPLLRQRSHEKLAQVQNTLGFDAIVRAPGSPLDPICKLASKLARYDLSILILGESGTGKEMLARAIHYASPRAAGPFVVENCAAVADTLLESELFGHKRGAFTGAVHDHAGLFQRANGGTIFLDEIGDTSLAFQVRLLRVLQEGEVRPVGATRAVPVDVRVIAATHRDLEREVEAGRFREDLYYRIATATLALPPLRERSGDLVPIAHRLLQAIAEHESRPAGLDFARDALAVLLGYAWPGNIRELRNEIYRAVALSDDDLIRADAFSPKVLRGQSGPAARRPEAQIASAGTLQERLDAMETMLIKEALLRHRWNKTRAASELGLSRAGLRQKMQRFGLEKK
>NZ_CP013421.1|WP_011880079.1|144030_145068_+|NADH-ubiquinone-oxidoreductase
MSVDTRAPDGTGAFNVLWLQSGGCGGCNMSLLCADTPDFSGMLSRAGIRLLWHPSLSLETGADARDVLLACLDGTVELHALCVEGAMLRGPNGTGRFHVLAGTGVPMIDWVARLASVAHYTVAIGTCAAYGGITAAGANPADACGLQYDGDQPGGLLGAAYRSRSGFPVVNVAGCPTHPDWVVETLSALSMSLLDPAALDTLGRPRFYADQLVHHGCTRNEFYEYKASAVRPSDLGCMMEHMGCKGTQAHADCNTRLWNGDGSCTRGGYACINCTEPGFEEPGHAFHRTPNVAGIPIGLPSDMPKAWFVALASLSKAATPKRVRENATADHLKVAPAVRSRPRNK
>NZ_CP013421.1|WP_011880080.1|145076_146534_+|nickel-dependent-hydrogenase-large-subunit
MSRLVIGPFNRVEGDLEVRIEVVDGRVSDAHVNATMFRGFEQILLDRDPLDALVYVPRICGICSVSQGVAAARALADLAGVTPAPNGQIATNLMLAAENLADHLSHFYLFFMPDFVRPVYAARAWHAEAVSRFTPYQGERHRASLAARQRWLRLMGTLGGKWPHTGSIQPGGSARAIDNAERIRLLGFIGEFRQFLEEVLFDAPLEEIAQLDSEAALAAWRARGERRGDLRFFLTLADDLGLDRLGAGPDLYLSYGAYPQPDGAHAFRGGVWDAQRKQADALDLDAITEDATHAWLDDAGGARHPFAGLTEPRADKPGAYTWNKAPRLNGAVLETGAIARQLADGHPLIADAVARCGGSVYTRVLARLLELARVVPMMEQWVRALAPGMPYCAAFALPDEGRAVGLNEAARGSLGHWLAVKDGRIANYQIIAPTSWNFSPRDAGGRPGALEAALIGAPVEPGETTPVAVQHIVRSFDPCMVCTVH

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Crispr_ID: NZ_CP013421_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013421_2

322412-322662

Orphan

Consensus_repeat	Method
GCCCGTGGAGAGCGAGCTCACGCCGGTCGACAGCGAGCTGGCCGTCGTCGACGTCGAGG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP013421_2

>merge|NZ_CP013421|2|322412-322662|PILER-CR
GCCCGTGGAGAGCGAACTCACGCCGGTCGACAGCGAGCTGGCCGTCGTCGACGTGGAAGTCGACAGCGACGCCACATTGCTGTTCGTCGTGGAGAGGCCCGTGGAGAGCGAGCTCACGCCGGTCGACAGCGAGCTGGCCGTCGTCGACGTCGAGGTCGACAGCGACGCAACGTTGCTGTTTGTCGTGGAGACGCCCGTCGAGAGCGAGCTCACGCCGGTCGACAGCGAGCTGGCCGTCGTCGACGTCGAGG

>NZ_CP013421|2|1|322412-322662|PILER-CR
GCCCGTGGAGAGCGAACTCACGCCGGTCGACAGCGAGCTGGCCGTCGTCGACGTGGAAG	TCGACAGCGACGCCACATTGCTGTTCGTCGTGGAGAGGCC
CGTGGAGAGCGAGCTCACGCCGGTCGACAGCGAGCTGGCCGTCGTCGACGTCGAGGTCG	ACAGCGACGCAACGTTGCTGTTTGTCGTGGAGACGCC
CGTCGAGAGCGAGCTCACGCCGGTCGACAGCGAGCTGGCCGTCGTCGACGTCGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013421.1\|WP_155121863.1\|334861_336036_-\|IS3-like-element-ISBvi4-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP013421.1\|WP_106919390.1\|307674_309543_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP013421.1\|WP_059460898.1\|312292_312919_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013421.1\|WP_080484362.1\|332158_333001_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP013421.1\|WP_155121933.1\|328142_329516_+\|galactosyl-transferase-GMA12/MNN10-domain-protein	unknown	unknown	gnl\|CDD\|368535
NZ_CP013421.1\|WP_059461598.1\|329488_330901_+\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|223864
NZ_CP013421.1\|WP_059460897.1\|312915_314037_-\|DUF2827-domain-containing-protein	unknown	unknown	gnl\|CDD\|371305
NZ_CP013421.1\|WP_045579737.1\|309936_310284_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013421.1\|WP_052691595.1\|326265_326973_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|376350
NZ_CP013421.1\|WP_060235538.1\|338169_338991_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371541
NZ_CP013421.1\|WP_045579740.1\|314033_315167_-\|DUF2827-domain-containing-protein	unknown	unknown	gnl\|CDD\|371305
NZ_CP013421.1\|WP_155121930.1\|307317_307554_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013421.1\|WP_069239529.1\|310297_311149_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131971
NZ_CP013421.1\|WP_045579745.1\|327475_328099_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP013421.1\|WP_045579738.1\|311153_312296_-\|DUF2827-domain-containing-protein	unknown	unknown	gnl\|CDD\|371305
NZ_CP013421.1\|WP_059669413.1\|309587_309899_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013421.1\|WP_069239534.1\|337229_338186_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NZ_CP013421.1\|WP_045579741.1\|315355_316051_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_CP013421.1\|WP_106919380.1\|331637_331874_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367555
NZ_CP013421.1\|WP_155121932.1\|325747_326221_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP013421.1\|WP_060235538.1\|338169_338991_-\|hypothetical-protein	gnl\|CDD\|371541	pfam11459, AbiEi_3, Transcriptional regulator, AbiEi antitoxin, Type IV TA system. AbiEi_3 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	5.25336e-39
NZ_CP013421.1\|WP_106919390.1\|307674_309543_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	3.77308e-16
NZ_CP013421.1\|WP_155121933.1\|328142_329516_+\|galactosyl-transferase-GMA12/MNN10-domain-protein	gnl\|CDD\|368535	pfam05637, Glyco_transf_34, galactosyl transferase GMA12/MNN10 family. This family contains a number of glycosyltransferase enzymes that contain a DXD motif. This family includes a number of C. elegans homologs where the DXD is replaced by DXH. Some members of this family are included in glycosyltransferase family 34.	1.82576e-05
NZ_CP013421.1\|WP_155121863.1\|334861_336036_-\|IS3-like-element-ISBvi4-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.6293e-72
NZ_CP013421.1\|WP_059460897.1\|312915_314037_-\|DUF2827-domain-containing-protein	gnl\|CDD\|371305	pfam10933, DUF2827, Protein of unknown function (DUF2827). This is a family of uncharacterized proteins found in Burkholderia.	0
NZ_CP013421.1\|WP_052691595.1\|326265_326973_-\|EAL-domain-containing-protein	gnl\|CDD\|376350	pfam00563, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.	1.54705e-24
NZ_CP013421.1\|WP_045579740.1\|314033_315167_-\|DUF2827-domain-containing-protein	gnl\|CDD\|371305	pfam10933, DUF2827, Protein of unknown function (DUF2827). This is a family of uncharacterized proteins found in Burkholderia.	6.86669e-158
NZ_CP013421.1\|WP_080484362.1\|332158_333001_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	1.21081e-55
NZ_CP013421.1\|WP_069239529.1\|310297_311149_-\|hypothetical-protein	gnl\|CDD\|131971	TIGR02925, hypothetical_protein_Nmul_A0241, peptidyl-prolyl cis-trans isomerase, EpsD family. Members of this family belong to the peptidyl-prolyl cis-trans isomerase family and are found in loci associated with exopolysaccharide biosynthesis. All members are encoded near a homolog of EpsH, as detected by TIGR02602.	4.15571e-08
NZ_CP013421.1\|WP_045579745.1\|327475_328099_+\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	1.31421e-50
NZ_CP013421.1\|WP_045579738.1\|311153_312296_-\|DUF2827-domain-containing-protein	gnl\|CDD\|371305	pfam10933, DUF2827, Protein of unknown function (DUF2827). This is a family of uncharacterized proteins found in Burkholderia.	1.03576e-173
NZ_CP013421.1\|WP_059461598.1\|329488_330901_+\|S41-family-peptidase	gnl\|CDD\|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	1.34797e-95
NZ_CP013421.1\|WP_069239534.1\|337229_338186_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	1.87094e-23
NZ_CP013421.1\|WP_045579741.1\|315355_316051_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	1.05543e-40
NZ_CP013421.1\|WP_106919380.1\|331637_331874_-\|hypothetical-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	2.86078e-06

>NZ_CP013421.1|WP_045579741.1|315355_316051_-|OmpA-family-protein
MLQRTKVVLLSAAVLAGCSASGPTFNAYSLRLANGEQAYRVDCYGIFEGQGTCHKKAEEICGNQPVRALEDAAPLGSTSDGKPNTRILTFQCGVPSAPPPVVAPVPVPVPPPPPPPPAKVVLGGDANFDTAKWTLRPEARAKLDKLVSDASGATFALVTVKGYTDSRGSDAYNLNLSQHRAETVAAYLRDHGLQAQRYAAHGYGKADPVASNDTVEGRAKNRRVEIQLDQR
>NZ_CP013421.1|WP_045579740.1|314033_315167_-|DUF2827-domain-containing-protein
MRIGISILTHAGQNIWENGLGQNVFFLARLLRALPFVTDVVLLNCGDQTSVAANAQDGGQPLRLIPMREATECIDVAIEMGGGLDVEWLDYLRARGKRVVFFCCGQPYVGLIEPSVFKRSGYFTRANRCDAIWILSKDRDFAPMLRTLHRCPVIEVPYLWDPVFVEQRAAEIERAGLHFGYQARQEHERGLRVAIFEPNISVVKNCAIPLLVCEAAARAEPESVSRVHVLNSVQMQRHPTFEFLTRSLELARDNKLQLDQRHDFVGYMSQFANAVVSHQWHNDQNILYLDALYGDYPLIHNAPWIAELGYYYPDSDIEQGASQLVSAASDHDDQLSHYRHRSRAFLSALSSQTRANRIAYAQCLLHLVGRTAQEGAR
>NZ_CP013421.1|WP_059460897.1|312915_314037_-|DUF2827-domain-containing-protein
MSVTKRLKIGVTIFLRKGHQSIWENGIFQNCYFLAQLLQRSPLIDSVVLVNGGDGEPHEAQAFLEHSPAPVIDLETARMELDVVIELSAQLNPDWARAFCARGGHVIGMRVANDYVIDIERMMFDLPHGMLASGTPYSAIWTLPAFERSCASYYGAALRAPVRAMQHLWSPALLERTLASSGNEGFGYAPGRARWRLAILEPNICMVKTSHVPMLLADLAHRQDPSFIEHLRVFNTLHLKDDAQFAGFARSLDLVNHGRATFEPRVPIYEILNRQADAIVAHHWENAQNYVYYEALYGGYALIHNSAFLSGCGYRYADFDCEDGALALRRAFAEHDVDLVRYRDEARQFLATLDPLAESNVAQYGAAIAELYE
>NZ_CP013421.1|WP_059460898.1|312292_312919_-|hypothetical-protein
MSTAMKRHGLVRGVGPAIRASLVSAAVAASVLAHAQGLAGDGAATPTPTPTPPTSVATTPATVLGRAAHAIGIRRCAGAIDAVASRAFVNAQRQDVVLDWDRSNPDGAPFFSLSGIEYRESSAILSLTTSPALQGGCTILAERISSAPLACREVARAELTGYQAAALVRGVTVYVDPHHSRETVTLVEAPPSCVIVRRQVQFSWGVSR
>NZ_CP013421.1|WP_045579738.1|311153_312296_-|DUF2827-domain-containing-protein
MNGQQQRQHPRALRIGITIGLHNEAESLWVNGIKQNALYLMRVFQHSPLKHAVCLVNTTQVAITPQLPWDLTQFPVKPFEAAKDDLDVLVELGGQINEAQCKYLQSRGARVVSYCCGPEYVQMMEAMIFRRRMTDQVFINQCYDQVWVIPQVMETSAHFFQTLRRKPVHQVPFVWDPMCLDARTVNLPNGGQYRPHAGPKRLSIMEPNIDVMKFCLYPLLIAEQAYRRVGAQIAHVHVTNADWLALGSPEFIGVMQYLDLVREHKASFVGRYETPQFLSELTDVVISHQWGLALNYYYFDVCWNGYALVHNAQLCAGLGYFYQGNDVEAGARQLVTALTRHDEQWQDYRTRQREVIGGFLATNPKVVAQYDQLLAGLFRG
>NZ_CP013421.1|WP_069239529.1|310297_311149_-|hypothetical-protein
MKHRAYMAGWMLVGCLAAAMGRAAESSASAQVALPTGTVALVNDVPIVRGEVDDVLAKTHLPDSPEMREVAVRGLIGRELVRQAALGEGLDRAPTVAGLTGTTRVNAENRLYLERHLQVPAVTDAQVKSAYDAMVAEQGPREYQTRIIAVRDAASAAGVLEKLKAGVAFDEVARETSMDSTREAGGALPWVSFKTPPAEGKTMGVALPIAQEIARLQPGHVSSTPIAVAGQFVIVKLEASRPTQTPSYDVAAPGVRKFLEARGRNAAFERLVAGLAEHARIVR
>NZ_CP013421.1|WP_045579737.1|309936_310284_-|hypothetical-protein
MRSFDSTDRFVANVFGAGAMTCAMTMMVGLLEMVWPTMNRISGWQRLALTTVVTVAFVTLVYAMATGLAYRTRKRSWLHRDSGARRAARQGRVVGIVAGLLMGNAFVLWWGSPLP
>NZ_CP013421.1|WP_059669413.1|309587_309899_-|hypothetical-protein
MTDYTDRFVGNTLIGIALTIAIVVVGMGLLDDLAGHWIARAWTQFGVTFVVAGGLLFTQPLVSRRLHRHEVLSSPVDAAVWLGRSVGWLVGALMGAVLASQFN
>NZ_CP013421.1|WP_106919390.1|307674_309543_-|tetratricopeptide-repeat-protein
MESLTQVEDLLETGDLLGAQRALNHYRPRNDDAQAYTLMSQLLRLRGRADQARALLDVYCVHYPSTRAMEIERARVALSLGDLKAADEAFAHASVEDAFDEDWVQEWIEVSSQLGHHANAIRLALMRCQHKPGEATRWFALGLVYQRARMHQQAMDAYAEVAQRDPHAPMLHNNIGAAHLELKAYASAQHELGLALRLDPGNALAWTNLATAALKQGKLDDALVAVERACALAPNYPTALQTYSYVLKECQQWQAALHVAQRALSLEPSNASMMWSVAMLELLLGDYSNGWLHHEARWAGSPELRDVAPNLPMPRWQGEPLAGKTLFVWGEQGHGDVFQFVRFVPALAERVEREGGSLIYSGFQHLQTLLARSLHGVVDTVVPHDQAELPRADFHLPLASIPFMQGITPEQLPVRTNYLRANPAKLDAWRRRLQKASSALKVGLVWSGSRSHQRNALRSVPPQALAQVFASAQAIEWFSLQLDAAEDVAALRAGGMTLVDVSEELHSFDDTAAIIANLDLVITVCTSVAHLAAAMGRPTWVLLDVNPHWVWMTERRDSPWYPSVTLYRQADYGDWTPVLEQVVKDLSALAVKRGPVPDYSPKRTSKGNSNDASTTRRAREST
>NZ_CP013421.1|WP_155121930.1|307317_307554_-|hypothetical-protein
MSARDSRARGNIRHIARAWCDRMVRAARRLSTSRQLGLGVLLGFALGLIAMLVIVLQSAEPPVPRVVASPRGAAVRWR
>NZ_CP013421.1|WP_155121932.1|325747_326221_-|hypothetical-protein
MSAMARPTKWKPIPGKELNLAGEAGGDVLQALSDCLGRCGESAPSMDRAEDWLEGLRRCAHLLVALHLPEWVSQATQAYDAGLAQGFYGTASAIGVGMEECLPGTGSGNSHVPLREPESSGHSDDQTIENQVRELTKSLRVLGREHGDELRRWLGLG
>NZ_CP013421.1|WP_052691595.1|326265_326973_-|EAL-domain-containing-protein
MTDMRVAEQIWDAMRTHRIQLHFSRIHRADDPNDVLYRECLARIPVADGQWRAASALLPALTRLNLVSTFERYVLRRVIQFLRDHPDEIVGVNFQCDGFDSAWTAALLELEVETDVAKRLIVEVPETSHVSREFVQFIRRAGCRIAIDGYGVAYGMRADIAIGHPDIVKFDPSLLTEARQADAGLEQLSRLIRLASDVATEAVVLTGVRGPQDLSVAARAGAPWVQPARDEPGAP
>NZ_CP013421.1|WP_045579745.1|327475_328099_+|recombinase-family-protein
MKVGYARVSTDEQDLALQIDALHDARCDALFTDQGVSGAVFDRPGLDSALATLQPGDALVVWRLDRLGRSLSKLVELIERLNKRGVEFISLMESINTQSSGGVLVFHVLAALAEFEKRLISERTRAGLAAARARGQRLGRRHSLDPGQRQRALEMLQTCSLTEVAREFDVHTRTLKRLVQEHTASTESAEPIAPIDPSGETGGDRES
>NZ_CP013421.1|WP_155121933.1|328142_329516_+|galactosyl-transferase-GMA12/MNN10-domain-protein
MPTCFVLSFLAEHSPTSVANHRAYADSRGYPHYVVDACDGPRGPQALALHKYQTLLDRLHVCANDDVVLLLTESALIVGDYPIEPLVAGRDELLVRTTETLPQVNLQIWRNGAASRERLARVVARCRLGGEPFPGEPALFADAAAHDWYQPLANICVVMNSSPNVDPAWARTPTLAISLGTAEQSPPELLAVPRFRRVLAEHIQSCRTTGRPFFHFEPPAQPDPDERSTYDAGQPIALVTLYTPEIARYGAIAEHNLRQYCARHGYTLYVHRGMPQEVGLSGTGNWIKPWLLHAYLQHHSWVVWVDADVLIHAPAQRLEPLLADRTVLLARDIGQWPFNSGVMGFAQIPANLELLALLMQRIASLADRSSVYAGNGDQHYFIQTMRELGLLDETAILSPRILNTPWFFAEPDSFLVHYYGMWLEMRTLMMDYDERRRLAAQPVRIGSLPCAPSLPSC
>NZ_CP013421.1|WP_059461598.1|329488_330901_+|S41-family-peptidase
MRAFVAFLLITAAGLARADGLPADVRRSLEQAFNLIKQDYAGRVDDATLMTAAIKGMVADLDPHSQFFERAEFAKLQEHLNGGFAGVGLQVGLSDGALRVAAPVDESPAAHAGIQAGDLVTRIDDVPTPGLTLENAVKHLRGEAGTRVRLALMRPSEDRSWTVVLTRAFIRTPSVTMARPAPGYGYVRISSFGEQTVPELADRLRTLAIAEPRLRGLVLDLRDNGGGVLQDAVGVASAFVPENTLVATVVDRNPEKSHAYRTTYADYRRPAYAADPLAGIAPRFKTVPLVVLTNAQSQSVTEVFAAALQDTKRAVVMGQPTFGKGTIQVTGGLSDGAGLMLTVARYYTPTGRSIQNRGVIPDIVVDEHRSGSPIGLPPLREVDLANRLPNPLDPDDDASRAAHEREVVAQLRAIETQRTRGTRIGNQADAPARNSKSGDALLRQALNWLRRNAAMQAADQSVMVTPRAIE
>NZ_CP013421.1|WP_106919380.1|331637_331874_-|hypothetical-protein
MDRLLRQAGAQDCGRRRVIARVLLDERGHVQDVVLKHSCGDSELDARALDALREQRYGVTRTGKRAVRRWQEVAYPVD
>NZ_CP013421.1|WP_080484362.1|332158_333001_-|recombinase-family-protein
MRIGYARVSTEEQNLDLQIDALRGSGCESIYSDQGISGAKINRPGLAEALRVLKAGDTLVVWKLDRLGRSIRDLISVMSDLNRSGIRFVSLTELIDTESSTGRFTFHMIAALAEFERALISERTRAGLEAARRRGSRLGRPKALQNNEIWHARELLAAHSESVVARSLQVHPRTLSRSLKIGEAQERGSEAPEEQKLDRHVNQMKCMQSDRLELYNGLQINNTICMECTGMLIPLGSMLFLSRRIGAKNHAVRDGAAKKPLSGVTVRMAANCVASKLGRP
>NZ_CP013421.1|WP_155121863.1|334861_336036_-|IS3-like-element-ISBvi4-family-transposase
MNRIPRAVYTKELRDEAVKLALAEGVGVSEASRRLSIPIKTLANWVRAAKAGKLKDVGRHQRPLTEMEAELAQVKRELAEVKMERDLPKKVRDVLREGVAVKYGVIEQMRQDYPVPPMCRVLGVSVSGYYAWRKRGPSERTQQEPRLEAEVLAAHQRTRESFGPERLKQHLDERGVRIGVHRIRRLRRKLGLRCKQKRRFKATTNSKHDLPVAPNLLNQDFSVTAPNQAWCGDITYIATDEGWLYLAGLKDLYSGEIVGYAMSERMTKNLVMQALFRAVATRRPPAGLIHHSDRGSQYCALAYQALIGQFDMRASMSRRGNCYDNAPIESFWGTLKNELVYHQRFATREQARLAISEYIEIFYNRQRTQARLNYQSPVAFTQRFYLNQIAA
>NZ_CP013421.1|WP_069239534.1|337229_338186_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MNTWLDHWDRRYTDRVRLLVEILPVLAEEPRFALKGGTAINLFEHDLPRLSVDIDLAWLPVRDYAEDARLIAEALGRLADVLRAWPLQLQVQLSAGGGAGVTRLVASRGRARVQIETTPVMRGTVHPARNMVVRPKVEEAFGFASAQVLDFADLYAGKLAAALSRQHPRDLFDVGLLLEDERADQMLWRTFLVYLTCSPKPAWEMLAPRVPADFAATFEAHFRGMTAEPVEAGVLLDIHVRLLSRVAGWLDEPSRAFLRSIEDERPDFDLIGLPHAAGLPAVRRKLLNLAQRTDAKRAADRGLLEEALTRIVGARSSR
>NZ_CP013421.1|WP_060235538.1|338169_338991_-|hypothetical-protein
MSEQNSGKLNLLLAELGDTSLVSSRWLRVHRYSSSLVARYVRSGWLVSPARGVYMRKGGRLQWEGVVRSLQVGEGMPLHVGGRFALSLQGHEHYLRLGDAGTITLYGVERPPAWLGKLSLAQRFEYLGKGPFDLPPVSFTVEVSATTLSEQGLAWNQAAPGADALVCSTPERAMLELCDGVSDVALIYEVDALMQAMTTLRPQRVGMLLRVCRSIKAKRLFLALAERHRHAWLSHVPLDGVDLGRGKRALVPGGRLHPTYQITLPGDLDEHLA

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP013421_2	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	NZ_CP013421.1	319624-319663	0	1.0
NZ_CP013421_2	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	NZ_CP013421.1	319912-319951	0	1.0
NZ_CP013421_2	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	NZ_CP013421.1	320296-320335	1	0.975
NZ_CP013421_2	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	NZ_CP013421.1	320647-320686	1	0.975
NZ_CP013421_2	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	NZ_CP013421.1	323713-323752	1	0.975
NZ_CP013421_2	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	NZ_CP013421.1	320392-320431	2	0.95
NZ_CP013421_2	2.2\|322570\|37\|NZ_CP013421\|PILER-CR	322570-322606	37	NZ_CP013421.1	320491-320527	0	1.0

1. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to position: 319624-319663, mismatch: 0, identity: 1.0

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacgccacattgctgttcgtcgtggagag	Protospacer
****************************************

2. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to position: 319912-319951, mismatch: 0, identity: 1.0

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacgccacattgctgttcgtcgtggagag	Protospacer
****************************************

3. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to position: 320296-320335, mismatch: 1, identity: 0.975

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacgccacattgctgttcgtcgtcgagag	Protospacer
********************************** *****

4. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to position: 320647-320686, mismatch: 1, identity: 0.975

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacgccacattgctgttcgtcgtcgagag	Protospacer
********************************** *****

5. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to position: 323713-323752, mismatch: 1, identity: 0.975

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacaccacattgctgttcgtcgtggagag	Protospacer
**************.*************************

6. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to position: 320392-320431, mismatch: 2, identity: 0.95

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacgcaacattgctgttcgtcgtcgagag	Protospacer
**************** ***************** *****

7. spacer 2.2|322570|37|NZ_CP013421|PILER-CR matches to position: 320491-320527, mismatch: 0, identity: 1.0

tcgacagcgacgcaacgttgctgtttgtcgtggagac	CRISPR spacer
tcgacagcgacgcaacgttgctgtttgtcgtggagac	Protospacer
*************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP013421_2	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	NC_010553	Burkholderia ambifaria MC40-6 plasmid pBMC401, complete sequence	75901-75940	6	0.85
NZ_CP013421_2	2.2\|322570\|37\|NZ_CP013421\|PILER-CR	322570-322606	37	NC_010553	Burkholderia ambifaria MC40-6 plasmid pBMC401, complete sequence	75904-75940	6	0.838
NZ_CP013421_2	2.2\|322570\|37\|NZ_CP013421\|PILER-CR	322570-322606	37	NZ_CP013412	Burkholderia thailandensis strain 2002721643 plasmid p2002721643, complete sequence	115791-115827	6	0.838
NZ_CP013421_2	2.2\|322570\|37\|NZ_CP013421\|PILER-CR	322570-322606	37	NZ_CP010016	Burkholderia thailandensis 34 plasmid unnamed, complete sequence	6913-6949	6	0.838

1. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to NC_010553 (Burkholderia ambifaria MC40-6 plasmid pBMC401, complete sequence) position: , mismatch: 6, identity: 0.85

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
cggtcgacagcgacgccacgttgctgttcgtcgtgctcag	Protospacer
 .*****************.***************   **

2. spacer 2.2|322570|37|NZ_CP013421|PILER-CR matches to NC_010553 (Burkholderia ambifaria MC40-6 plasmid pBMC401, complete sequence) position: , mismatch: 6, identity: 0.838

tcgacagcgacgcaacgttgctgtttgtcgtggagac	CRISPR spacer
tcgacagcgacgccacgttgctgttcgtcgtgctcag	Protospacer
************* ***********.******   *

3. spacer 2.2|322570|37|NZ_CP013421|PILER-CR matches to NZ_CP013412 (Burkholderia thailandensis strain 2002721643 plasmid p2002721643, complete sequence) position: , mismatch: 6, identity: 0.838

tcgacagcgacgcaacgttgctgtttgtcgtggagac	CRISPR spacer
tcgacagcgacgcgacgttgctgttggtcgtgctcag	Protospacer
*************.*********** ******   *

4. spacer 2.2|322570|37|NZ_CP013421|PILER-CR matches to NZ_CP010016 (Burkholderia thailandensis 34 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.838

tcgacagcgacgcaacgttgctgtttgtcgtggagac	CRISPR spacer
tcgacagcgacgcgacgttgctgttggtcgtgctcag	Protospacer
*************.*********** ******   *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

29605 : 67632

Synechococcus_phage(25.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_081333277.1\|29605_29926_+\|transposase	transposase	NA	NA	NA	NA
WP_011880403.1\|30213_31377_-	GGDEF domain-containing protein	NA	NA	NA	NA
WP_069239456.1\|31778_33536_-	SulP family inorganic anion transporter	NA	NA	NA	NA
WP_069239457.1\|33737_33959_-	hypothetical protein	NA	NA	NA	NA
WP_155121916.1\|34099_35140_-	TIGR00730 family Rossman fold protein	F4YCQ1	Synechococcus_phage	2.0e-09	37.6
WP_069239459.1\|35162_35498_-	cytochrome C	NA	NA	NA	NA
WP_069239460.1\|35517_36519_-	nitroreductase	NA	NA	NA	NA
WP_069239461.1\|36695_37685_+	zinc-dependent alcohol dehydrogenase family protein	A0A0G2YAX3	Acanthamoeba_polyphaga_mimivirus	1.7e-18	30.9
WP_069239462.1\|37810_38584_-	fumarate/nitrate reduction transcriptional regulator Fnr	NA	NA	NA	NA
WP_060236567.1\|38966_39614_-	response regulator transcription factor	NA	NA	NA	NA
WP_069239463.1\|40226_40697_+	universal stress protein	NA	NA	NA	NA
WP_069239464.1\|40757_41591_-	universal stress protein	NA	NA	NA	NA
WP_069239465.1\|41587_42091_-	universal stress protein	NA	NA	NA	NA
WP_069239466.1\|42160_43360_-	acetate/propionate family kinase	NA	NA	NA	NA
WP_069239467.1\|43368_44208_-	universal stress protein	NA	NA	NA	NA
WP_011880389.1\|44396_44927_+	hypothetical protein	NA	NA	NA	NA
WP_069239468.1\|44916_45663_+	beta-ketoacyl-ACP reductase	NA	NA	NA	NA
WP_080484337.1\|45796_47611_+	poly-beta-hydroxybutyrate polymerase	NA	NA	NA	NA
WP_069239469.1\|47630_48671_+	zinc-dependent alcohol dehydrogenase family protein	E3SJ82	Synechococcus_phage	2.4e-15	26.7
WP_059464014.1\|48908_50360_-\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_059474834.1\|50528_50714_+	barstar family protein	NA	NA	NA	NA
WP_069239470.1\|50765_52304_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	6.3e-44	35.2
WP_155121917.1\|52302_52638_+	hypothetical protein	NA	NA	NA	NA
WP_080484338.1\|52647_54480_+	LysM peptidoglycan-binding domain-containing protein	Q6A204	Oenococcus_phage	2.4e-05	36.5
WP_155121918.1\|54492_55098_+	hypothetical protein	NA	NA	NA	NA
WP_080484339.1\|55163_55421_+	PAAR domain-containing protein	NA	NA	NA	NA
WP_155121919.1\|55689_55884_-	hypothetical protein	NA	NA	NA	NA
WP_043292613.1\|56660_57095_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011879997.1\|57204_57822_+	FMN-dependent NADH-azoreductase	NA	NA	NA	NA
WP_069239473.1\|58407_59319_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_080484340.1\|59342_60008_+	DsbA family protein	NA	NA	NA	NA
WP_069239475.1\|62091_63906_+	diguanylate cyclase	A0A127AWB9	Bacillus_phage	1.8e-21	35.1
WP_046429363.1\|64057_64465_+\|transposase	transposase	NA	NA	NA	NA
WP_069239476.1\|64923_66144_+\|transposase	ISL3 family transposase	A9YX10	Burkholderia_phage	9.5e-229	93.6
WP_069239477.1\|66639_67632_+\|transposase	IS5 family transposase	E5E3P6	Burkholderia_phage	1.4e-158	86.0

DBSCAN-SWA_2

243641 : 282698

Bacillus_phage(16.67%)

transposase,integrase

attL 250700:250759|attR 277836:278327

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_069239509.1\|243641_245339_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_126221107.1\|245435_245840_-	hypothetical protein	NA	NA	NA	NA
WP_126221193.1\|245966_247400_-	TolC family protein	NA	NA	NA	NA
WP_059475418.1\|247431_248850_-	HlyD family type I secretion periplasmic adaptor subunit	NA	NA	NA	NA
WP_080484351.1\|248861_250757_-	type I secretion system permease/ATPase	W8CYL7	Bacillus_phage	1.3e-38	27.8
250700:250759	attL	NA	NA	NA	NA
WP_155121863.1\|250759_251933_+\|transposase	IS3-like element ISBvi4 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.9e-75	48.9
WP_080484352.1\|252753_253428_-	response regulator transcription factor	NA	NA	NA	NA
WP_155121926.1\|253684_254665_+	hypothetical protein	NA	NA	NA	NA
WP_069239513.1\|254664_256752_+	hybrid sensor histidine kinase/response regulator	A0A1V0SGX0	Hokovirus	1.6e-42	34.1
WP_069239515.1\|258053_258605_+	type 1 fimbrial protein	NA	NA	NA	NA
WP_069239516.1\|258673_259393_+	fimbria/pilus periplasmic chaperone	NA	NA	NA	NA
WP_080484353.1\|259566_262002_+	fimbrial biogenesis outer membrane usher protein	NA	NA	NA	NA
WP_080484354.1\|262537_263215_+	type 1 fimbrial protein	NA	NA	NA	NA
WP_080484355.1\|264021_264726_+	response regulator transcription factor	NA	NA	NA	NA
WP_069239518.1\|265045_266158_+	EAL domain-containing protein	NA	NA	NA	NA
WP_045579196.1\|267797_268541_-	carbonic anhydrase	NA	NA	NA	NA
WP_069239519.1\|269143_270223_-	linear amide C-N hydrolase	A0A2K9L5Y5	Tupanvirus	2.2e-19	28.9
WP_045579193.1\|270613_270922_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_045579192.1\|270918_271161_+	hypothetical protein	NA	NA	NA	NA
WP_045579191.1\|271747_273214_+	amidohydrolase family protein	NA	NA	NA	NA
WP_155121927.1\|273335_273509_+	hypothetical protein	NA	NA	NA	NA
WP_144410671.1\|273514_273712_+	hypothetical protein	NA	NA	NA	NA
WP_045579190.1\|274010_275648_+	Na+/H+ antiporter	NA	NA	NA	NA
WP_069239520.1\|275877_277569_-\|integrase	tyrosine-type recombinase/integrase	A0A2K9VH72	Gordonia_phage	6.3e-05	30.9
WP_155121928.1\|278366_279454_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.2e-42	35.2
277836:278327	attR	NA	NA	NA	NA
WP_155121929.1\|280325_280718_+	hypothetical protein	NA	NA	NA	NA
WP_069239522.1\|281561_282698_+\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

288081 : 348775

Burkholderia_phage(16.67%)

transposase,integrase

attL 343975:343992|attR 361525:361542

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_069239522.1\|288081_289218_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_043291788.1\|289907_290900_+\|transposase	IS5 family transposase	E5E3P6	Burkholderia_phage	1.1e-158	86.0
WP_080484358.1\|290874_291321_+	H-NS histone family protein	NA	NA	NA	NA
WP_069239526.1\|291756_292800_-	DUF1016 domain-containing protein	Q9JMP5	Wolbachia_phage	2.5e-105	51.9
WP_069239527.1\|294001_298387_-	hemagglutinin	NA	NA	NA	NA
WP_043291788.1\|299345_300338_+\|transposase	IS5 family transposase	E5E3P6	Burkholderia_phage	1.1e-158	86.0
WP_045579729.1\|301008_301458_-	hypothetical protein	NA	NA	NA	NA
WP_059460903.1\|301566_302907_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_045579731.1\|303273_303969_-	aquaporin Z	NA	NA	NA	NA
WP_045579732.1\|304064_304577_-	OmpA family protein	NA	NA	NA	NA
WP_144410687.1\|304573_304843_-	hypothetical protein	NA	NA	NA	NA
WP_045579734.1\|304861_305443_-	hypothetical protein	NA	NA	NA	NA
WP_059460901.1\|305469_305799_-	H-NS histone family protein	NA	NA	NA	NA
WP_144410688.1\|305890_306085_-	hypothetical protein	NA	NA	NA	NA
WP_059669414.1\|306081_306837_-	class I SAM-dependent methyltransferase	A0A1V0S9B9	Catovirus	1.2e-35	39.5
WP_045579969.1\|306833_307274_-	hypothetical protein	NA	NA	NA	NA
WP_155121930.1\|307317_307554_-	hypothetical protein	NA	NA	NA	NA
WP_106919390.1\|307674_309543_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_059669413.1\|309587_309899_-	hypothetical protein	NA	NA	NA	NA
WP_045579737.1\|309936_310284_-	hypothetical protein	NA	NA	NA	NA
WP_069239529.1\|310297_311149_-	hypothetical protein	NA	NA	NA	NA
WP_045579738.1\|311153_312296_-	DUF2827 domain-containing protein	NA	NA	NA	NA
WP_059460898.1\|312292_312919_-	hypothetical protein	NA	NA	NA	NA
WP_059460897.1\|312915_314037_-	DUF2827 domain-containing protein	NA	NA	NA	NA
WP_045579740.1\|314033_315167_-	DUF2827 domain-containing protein	NA	NA	NA	NA
WP_045579741.1\|315355_316051_-	OmpA family protein	G3M9Z1	Bacillus_virus	5.6e-08	33.7
WP_155121931.1\|316141_325645_-	hemagglutinin	NA	NA	NA	NA
WP_155121932.1\|325747_326221_-	hypothetical protein	NA	NA	NA	NA
WP_052691595.1\|326265_326973_-	EAL domain-containing protein	NA	NA	NA	NA
WP_045579745.1\|327475_328099_+	recombinase family protein	A0JC18	Ralstonia_phage	1.4e-34	41.4
WP_155121933.1\|328142_329516_+	galactosyl transferase GMA12/MNN10 domain protein	NA	NA	NA	NA
WP_059461598.1\|329488_330901_+	S41 family peptidase	A0A0R6PIZ1	Moraxella_phage	8.4e-19	27.0
WP_106919380.1\|331637_331874_-	hypothetical protein	NA	NA	NA	NA
WP_080484362.1\|332158_333001_-	recombinase family protein	A0A0F7LA37	Escherichia_phage	2.4e-37	56.3
WP_155121863.1\|334861_336036_-\|transposase	IS3-like element ISBvi4 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.9e-75	48.9
WP_069239534.1\|337229_338186_-	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_060235538.1\|338169_338991_-	hypothetical protein	NA	NA	NA	NA
WP_059461595.1\|340235_341408_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_059460485.1\|341488_343027_-\|transposase	IS3-like element ISBmu11 family transposase	A0A1B1P773	Bacillus_phage	2.8e-44	35.2
WP_155121948.1\|343124_344322_+\|transposase	IS3 family transposase	A0A1B0Z042	Pseudomonas_phage	7.2e-104	65.5
343975:343992	attL	NA	NA	NA	NA
WP_155121934.1\|345358_345544_+	hypothetical protein	NA	NA	NA	NA
WP_155121935.1\|345600_346470_+	hypothetical protein	NA	NA	NA	NA
WP_155121936.1\|346601_347969_+	hypothetical protein	NA	NA	NA	NA
WP_059461600.1\|348148_348775_-\|integrase	tyrosine-type recombinase/integrase	A0A1S5SFL0	Streptococcus_phage	9.2e-10	28.4
361525:361542	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_CP013421.1|WP_106919380.1|331637_331874_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP013421.1|WP_106919380.1|331637_331874_-|hypothetical-protein

331637_331874_-

78 aa aa

288081-348775

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP013421_2	Orphan	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	319624-319663	0
NZ_CP013421_2	Orphan	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	319912-319951	0
NZ_CP013421_2	Orphan	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	320296-320335	1
NZ_CP013421_2	Orphan	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	320647-320686	1
NZ_CP013421_2	Orphan	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	323713-323752	1
NZ_CP013421_2	Orphan	2.1\|322471\|40\|NZ_CP013421\|PILER-CR	322471-322510	40	320392-320431	2
NZ_CP013421_2	Orphan	2.2\|322570\|37\|NZ_CP013421\|PILER-CR	322570-322606	37	320491-320527	0

1. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to NZ_CP013421 position: 319624-319663, mismatch: 0

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacgccacattgctgttcgtcgtggagag	Protospacer
****************************************

2. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to NZ_CP013421 position: 319912-319951, mismatch: 0

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacgccacattgctgttcgtcgtggagag	Protospacer
****************************************

3. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to NZ_CP013421 position: 320296-320335, mismatch: 1

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacgccacattgctgttcgtcgtcgagag	Protospacer
********************************** *****

4. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to NZ_CP013421 position: 320647-320686, mismatch: 1

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacgccacattgctgttcgtcgtcgagag	Protospacer
********************************** *****

5. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to NZ_CP013421 position: 323713-323752, mismatch: 1

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacaccacattgctgttcgtcgtggagag	Protospacer
**************.*************************

6. spacer 2.1|322471|40|NZ_CP013421|PILER-CR matches to NZ_CP013421 position: 320392-320431, mismatch: 2

aagtcgacagcgacgccacattgctgttcgtcgtggagag	CRISPR spacer
aagtcgacagcgacgcaacattgctgttcgtcgtcgagag	Protospacer
**************** ***************** *****

7. spacer 2.2|322570|37|NZ_CP013421|PILER-CR matches to NZ_CP013421 position: 320491-320527, mismatch: 0

tcgacagcgacgcaacgttgctgtttgtcgtggagac	CRISPR spacer
tcgacagcgacgcaacgttgctgtttgtcgtggagac	Protospacer
*************************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP013420

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP013422

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP013421

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information