CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP016979	Brucella sp. 2002734562 chromosome 1, complete sequence	0 crisprs	csa3,WYL,DEDDh	0	0	2	0
NZ_CP016980	Brucella sp. 2002734562 chromosome 2, complete sequence	1 crisprs	csa3,cas3,DEDDh	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

542036 : 648195

100

Paenibacillus_phage(10.0%)

portal,capsid,tail,holin,transposase,protease,head,integrase

attL 640775:640789|attR 650666:650680

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_109790517.1\|542036_542793_+\|transposase	IS5 family transposase	A0A0N9SJT9	Paenibacillus_phage	2.7e-16	41.0
WP_002968716.1\|543164_544283_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_077281774.1\|545040_545193_-	hypothetical protein	NA	NA	NA	NA
WP_126358176.1\|545427_545790_-	hypothetical protein	NA	NA	NA	NA
WP_094866392.1\|545952_546715_+\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	1.3e-21	40.8
WP_002975117.1\|546612_546930_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_002963688.1\|547540_548896_+	phosphomannomutase	NA	NA	NA	NA
WP_002963689.1\|548966_550391_+	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	9.0e-53	30.8
WP_002963690.1\|550423_551596_+	AGE family epimerase/isomerase	NA	NA	NA	NA
WP_002969456.1\|551678_552788_+	glycosyltransferase	NA	NA	NA	NA
WP_109790518.1\|553136_553340_+	hypothetical protein	NA	NA	NA	NA
WP_002963692.1\|553479_555015_+	sugar ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.4e-14	25.3
WP_002963693.1\|555035_556037_+	ABC transporter permease	NA	NA	NA	NA
WP_002969455.1\|556115_557078_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_002963695.1\|557135_558188_+	sugar phosphate isomerase/epimerase	NA	NA	NA	NA
WP_002969454.1\|558195_559293_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_002966715.1\|559334_560642_-	xylose isomerase	NA	NA	NA	NA
WP_002966716.1\|560688_562140_-	xylulokinase	NA	NA	NA	NA
WP_069141972.1\|562172_563204_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_002971540.1\|563465_563984_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_002969452.1\|563890_564460_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_002963701.1\|564997_566461_-	betaine-aldehyde dehydrogenase	NA	NA	NA	NA
WP_002966717.1\|566612_568295_-\|holin	choline dehydrogenase	A0A1V0S9M4	Catovirus	7.9e-40	30.6
WP_002969060.1\|568297_568894_-	transcriptional regulator BetI	NA	NA	NA	NA
WP_002963705.1\|569084_570107_+	asparaginase	NA	NA	NA	NA
WP_002963706.1\|570151_570622_+	transcription elongation factor	NA	NA	NA	NA
WP_002963707.1\|570618_571008_-	type II toxin-antitoxin system death-on-curing family toxin	A0A1B3AYM0	Gordonia_phage	3.5e-07	44.6
WP_002963708.1\|571004_571235_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_002963709.1\|571295_572288_-	magnesium transporter CorA family protein	NA	NA	NA	NA
WP_002969451.1\|572443_572806_+	FadR family transcriptional regulator	NA	NA	NA	NA
WP_002969450.1\|572802_573123_+	FadR family transcriptional regulator	NA	NA	NA	NA
WP_002963712.1\|574454_574817_-	hypothetical protein	NA	NA	NA	NA
WP_002963713.1\|575152_576664_+	DUF853 domain-containing protein	A0A248XCZ8	Klebsiella_phage	1.4e-83	44.3
WP_002963714.1\|576853_577570_-	L,D-transpeptidase	NA	NA	NA	NA
WP_002971536.1\|577628_577871_+	hypothetical protein	NA	NA	NA	NA
WP_002963715.1\|577872_578526_-	haloacid dehalogenase type II	NA	NA	NA	NA
WP_002963716.1\|578748_579348_+	superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	1.2e-38	42.6
WP_002963717.1\|579519_579855_-	hypothetical protein	NA	NA	NA	NA
WP_002963718.1\|579972_582081_-	S9 family peptidase	NA	NA	NA	NA
WP_002963720.1\|582653_583082_+	MucR family transcriptional regulator	A0A1P8VVG0	Erythrobacter_phage	1.0e-20	47.6
WP_002969861.1\|583289_583601_-	hypothetical protein	NA	NA	NA	NA
WP_002966719.1\|583781_584237_+	hypothetical protein	NA	NA	NA	NA
WP_002969449.1\|584233_585028_+	hypothetical protein	NA	NA	NA	NA
WP_002966720.1\|585138_586455_+	amidase	NA	NA	NA	NA
WP_002963725.1\|586495_586921_-	SufE family protein	NA	NA	NA	NA
WP_002963726.1\|587000_587450_-	hypothetical protein	NA	NA	NA	NA
WP_002969448.1\|587740_589570_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	4.7e-22	28.9
WP_002971535.1\|589544_590513_+	peptidoglycan-binding protein	NA	NA	NA	NA
WP_002963729.1\|590526_590874_+	DUF1491 family protein	NA	NA	NA	NA
WP_002969865.1\|590884_591961_-	DUF2336 domain-containing protein	NA	NA	NA	NA
WP_002963731.1\|592158_592701_-	hypothetical protein	NA	NA	NA	NA
WP_002963732.1\|592693_593305_-	DUF1214 domain-containing protein	NA	NA	NA	NA
WP_002969866.1\|593311_595486_-	penicillin-binding protein 1A	NA	NA	NA	NA
WP_002963734.1\|595825_596338_+	hypothetical protein	NA	NA	NA	NA
WP_002970982.1\|596276_597524_+	DNA-packaging protein	A0A1V0DY66	Dinoroseobacter_phage	4.9e-71	40.4
WP_002963736.1\|597555_598749_+\|portal	phage portal protein	W8ECU7	Geobacillus_phage	7.0e-67	40.0
WP_002963737.1\|598745_599123_+	hypothetical protein	NA	NA	NA	NA
WP_002963738.1\|599109_599778_+\|head,protease	HK97 family phage prohead protease	A0A2H4JAI0	uncultured_Caudovirales_phage	1.7e-30	41.1
WP_002966724.1\|599799_601074_+\|capsid	phage major capsid protein	Q8HAD2	Salmonella_phage	2.8e-82	43.6
WP_002963740.1\|601238_601805_+	hypothetical protein	NA	NA	NA	NA
WP_002963741.1\|601801_602140_+\|head	phage head closure protein	NA	NA	NA	NA
WP_006072374.1\|602262_602670_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_002963743.1\|602710_603124_+\|tail	phage major tail protein, TP901-1 family	NA	NA	NA	NA
WP_002963744.1\|603120_603462_+	gene transfer agent family protein	NA	NA	NA	NA
WP_002963745.1\|603505_603676_+\|tail	phage tail assembly chaperone	NA	NA	NA	NA
WP_002970984.1\|603680_604226_+\|tail	phage tail tape measure protein	A0A0S2SYD9	Pseudomonas_phage	2.8e-07	46.4
WP_002963747.1\|604228_604861_+	TIGR02217 family protein	A0A0B5A2K3	Paracoccus_phage	2.9e-48	47.6
WP_002963749.1\|605728_606151_+	peptidase P60	NA	NA	NA	NA
WP_002969445.1\|610082_610289_+	hypothetical protein	NA	NA	NA	NA
WP_002971526.1\|610450_610747_+	hypothetical protein	NA	NA	NA	NA
WP_002963753.1\|610825_611515_+	response regulator transcription factor	NA	NA	NA	NA
WP_002969444.1\|611589_612900_+	hypothetical protein	NA	NA	NA	NA
WP_002971524.1\|612993_613446_+	hypothetical protein	NA	NA	NA	NA
WP_002969443.1\|613546_614686_+	c-type cytochrome biogenesis protein CcmI	NA	NA	NA	NA
WP_002963757.1\|614682_615180_+	cytochrome c maturation protein CcmE	NA	NA	NA	NA
WP_002963758.1\|615199_617191_+	heme lyase CcmF/NrfE family subunit	NA	NA	NA	NA
WP_002963759.1\|617187_617664_+	cytochrome c-type biogenesis protein CcmH	NA	NA	NA	NA
WP_002963760.1\|617805_619347_+\|protease	DegQ family serine endoprotease	A0A1B1IT49	uncultured_Mediterranean_phage	1.7e-28	29.8
WP_002969442.1\|619440_620148_+	response regulator transcription factor	NA	NA	NA	NA
WP_002966726.1\|620144_621551_+	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_002969873.1\|621673_624625_+	bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase	NA	NA	NA	NA
WP_002966727.1\|624669_626781_-	hypothetical protein	NA	NA	NA	NA
WP_002969440.1\|627051_629403_-	PAS domain-containing protein	A0A1V0SGX0	Hokovirus	6.3e-27	34.8
WP_002968720.1\|629793_632445_-	aminopeptidase N	NA	NA	NA	NA
WP_002963767.1\|632670_633630_+	DMT family transporter	NA	NA	NA	NA
WP_002970986.1\|633634_634891_-	MFS transporter	NA	NA	NA	NA
WP_002963769.1\|635052_635925_-	uracil-DNA glycosylase	NA	NA	NA	NA
WP_002963770.1\|636313_638005_+	electron transfer flavoprotein-ubiquinone oxidoreductase	NA	NA	NA	NA
WP_002969439.1\|638120_639089_-	AP endonuclease	NA	NA	NA	NA
WP_002963772.1\|639257_640760_-	AMP nucleosidase	NA	NA	NA	NA
640775:640789	attL	NA	NA	NA	NA
WP_002963775.1\|641326_642037_+	thiol:disulfide oxidoreductase	NA	NA	NA	NA
WP_002963776.1\|642095_642443_-	DUF2147 domain-containing protein	NA	NA	NA	NA
WP_002969438.1\|642439_642673_-	hypothetical protein	NA	NA	NA	NA
WP_002963778.1\|642942_643200_+	hypothetical protein	NA	NA	NA	NA
WP_002963779.1\|643259_644030_-	YitT family protein	NA	NA	NA	NA
WP_154018645.1\|644089_644362_-	hypothetical protein	NA	NA	NA	NA
WP_002963780.1\|644685_645336_+	hypothetical protein	NA	NA	NA	NA
WP_002963781.1\|645380_645755_-	DUF423 domain-containing protein	NA	NA	NA	NA
WP_002963782.1\|645772_646906_-	pyridoxal phosphate-dependent aminotransferase	A0A1X7QHI1	Faustovirus	9.1e-16	23.9
WP_002967515.1\|647268_648195_-\|integrase	site-specific integrase	A0A076YL28	Mesorhizobium_phage	2.9e-28	36.3
650666:650680	attR	NA	NA	NA	NA

DBSCAN-SWA_2

872157 : 884085

uncultured_Mediterranean_phage(90.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002968731.1\|872157_873009_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	4.4e-31	33.5
WP_002964011.1\|873001_873727_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	1.5e-43	45.7
WP_002964012.1\|873872_874091_+	twin-arginine translocase TatA/TatE family subunit	A0A1B1IVR9	uncultured_Mediterranean_phage	1.5e-07	65.1
WP_002969412.1\|874201_874783_+	twin-arginine translocase subunit TatB	NA	NA	NA	NA
WP_002964014.1\|874779_875604_+	twin-arginine translocase subunit TatC	A0A1B1IVR7	uncultured_Mediterranean_phage	9.8e-44	41.1
WP_002964015.1\|875680_876964_+\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	1.2e-104	47.2
WP_002966786.1\|877112_877880_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.0e-39	40.2
WP_002964017.1\|877876_878545_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	4.2e-13	37.8
WP_002964018.1\|878689_878875_+	hypothetical protein	NA	NA	NA	NA
WP_002964019.1\|878923_880222_+	peptidoglycan DD-metalloendopeptidase family protein	Q8SBN9	Clostridium_phage	1.0e-18	41.1
WP_002964020.1\|880270_881137_-	ATP-binding protein	NA	NA	NA	NA
WP_002964021.1\|881297_881639_+	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	9.1e-12	40.2
WP_002969969.1\|881757_884085_+	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	6.2e-51	43.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP016980

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016980_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016980_1

182015-182115

Orphan

Consensus_repeat	Method
ATGGACTTCTTGGAAGTCCATGCCGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016980_1

>merge|NZ_CP016980|1|182015-182115|CRISPRCasFinder
ATGGACTTCTTGGAAGTCCATGCCGCCCCCGCGCCGCTTTGCGGCGCAGGCATTTAGTTCATGGGCGAGCTTTATGGACTTCTTAGAAGTCCATGCCGCCC

>NZ_CP016980|1|1|182015-182115|CRISPRCasFinder
ATGGACTTCTTGGAAGTCCATGCCGCCC	CCGCGCCGCTTTGCGGCGCAGGCATTTAGTTCATGGGCGAGCTTT
ATGGACTTCTTAGAAGTCCATGCCGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016980.1\|WP_002966383.1\|185540_186530_+\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NZ_CP016980.1\|WP_002972153.1\|175625_176756_+\|ATP-phosphoribosyltransferase-regulatory-subunit	unknown	unknown	gnl\|CDD\|183413
NZ_CP016980.1\|WP_002966392.1\|177520_178759_-\|sugar-MFS-transporter	unknown	unknown	gnl\|CDD\|340952
NZ_CP016980.1\|WP_002967192.1\|190999_191560_+\|cytochrome-b	unknown	unknown	gnl\|CDD\|225580
NZ_CP016980.1\|WP_002971287.1\|189983_190655_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016980.1\|WP_002972147.1\|184604_185453_+\|TIGR01459-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|319827
NZ_CP016980.1\|WP_002966379.1\|191613_192087_-\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NZ_CP016980.1\|WP_002966391.1\|179044_179446_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP016980.1\|WP_002966386.1\|183827_184124_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NZ_CP016980.1\|WP_002966378.1\|192227_193973_+\|pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NZ_CP016980.1\|WP_002966390.1\|179548_180940_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NZ_CP016980.1\|WP_002966396.1\|173380_173998_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP016980.1\|WP_002972151.1\|181089_181344_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016980.1\|WP_002968994.1\|170529_171357_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381357
NZ_CP016980.1\|WP_002966393.1\|176752_177448_+\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|237438
NZ_CP016980.1\|WP_002969286.1\|194602_196147_+\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NZ_CP016980.1\|WP_002966377.1\|193953_194517_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|223813
NZ_CP016980.1\|WP_002967189.1\|172605_173262_+\|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl\|CDD\|377025
NZ_CP016980.1\|WP_002966382.1\|186873_189792_+\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237514
NZ_CP016980.1\|WP_002968826.1\|174108_175617_+\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|223202

Protein	Function_ID	Function_description	E-value
NZ_CP016980.1\|WP_002966383.1\|185540_186530_+\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	2.77791e-157
NZ_CP016980.1\|WP_002966391.1\|179044_179446_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	2.4232e-20
NZ_CP016980.1\|WP_002966392.1\|177520_178759_-\|sugar-MFS-transporter	gnl\|CDD\|340952	cd17394, MFS_FucP_like, Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.18971e-166
NZ_CP016980.1\|WP_002967192.1\|190999_191560_+\|cytochrome-b	gnl\|CDD\|225580	COG3038, CybB, Cytochrome B561 [Energy production and conversion].	7.89145e-52
NZ_CP016980.1\|WP_002972147.1\|184604_185453_+\|TIGR01459-family-HAD-type-hydrolase	gnl\|CDD\|319827	cd07525, HAD_like, uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.51221e-90
NZ_CP016980.1\|WP_002966379.1\|191613_192087_-\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	5.96751e-65
NZ_CP016980.1\|WP_002972153.1\|175625_176756_+\|ATP-phosphoribosyltransferase-regulatory-subunit	gnl\|CDD\|183413	PRK12295, hisZ, ATP phosphoribosyltransferase regulatory subunit; Provisional.	2.67267e-157
NZ_CP016980.1\|WP_002966386.1\|183827_184124_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	5.80408e-54
NZ_CP016980.1\|WP_002966378.1\|192227_193973_+\|pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	6.08227e-83
NZ_CP016980.1\|WP_002966390.1\|179548_180940_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_CP016980.1\|WP_002966393.1\|176752_177448_+\|ATP-phosphoribosyltransferase	gnl\|CDD\|237438	PRK13583, hisG, ATP phosphoribosyltransferase.	1.16784e-135
NZ_CP016980.1\|WP_002968994.1\|170529_171357_-\|aldo/keto-reductase	gnl\|CDD\|381357	cd19131, AKR_AKR5C2, Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins. Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.	3.08102e-178
NZ_CP016980.1\|WP_002966396.1\|173380_173998_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	9.51794e-45
NZ_CP016980.1\|WP_002969286.1\|194602_196147_+\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	4.11164e-117
NZ_CP016980.1\|WP_002966377.1\|193953_194517_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|223813	COG0742, COG0742, N6-adenine-specific methylase [DNA replication, recombination, and repair].	1.21532e-78
NZ_CP016980.1\|WP_002967189.1\|172605_173262_+\|DNA-3-methyladenine-glycosylase-I	gnl\|CDD\|377025	pfam03352, Adenine_glyco, Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.	3.88001e-109
NZ_CP016980.1\|WP_002966382.1\|186873_189792_+\|isoleucine--tRNA-ligase	gnl\|CDD\|237514	PRK13804, ileS, isoleucyl-tRNA synthetase; Provisional.	0
NZ_CP016980.1\|WP_002968826.1\|174108_175617_+\|histidine--tRNA-ligase	gnl\|CDD\|223202	COG0124, HisS, Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].	2.87411e-159

>NZ_CP016980.1|WP_002972151.1|181089_181344_-|hypothetical-protein
MRKELPIETAPKDGRKITVIWIDDDDQRNESIAQYRTLEQLRAGGGQWDEADTGWWTFTDNKTQRKIEPTAWIRETDDDESQED
>NZ_CP016980.1|WP_002966390.1|179548_180940_-|class-II-fumarate-hydratase
MAATRTETDTFGPIDVPADRYWGAQTQRSLQNFRIGGERMPLPLVHALGVVKRAAAETNIALGKLDPVLGQVIAVAASEVIEGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGEMGSKKPIHPNDHVNMSQSSNDSFPTAIHIATAVETVNRLYPALEHLTKALKVKEEAFKDIIKIGRTHTQDATPVTLGQEFSGYRAALEYARHRLEQSLADVFLLAQGGTAVGTGLNAPVGFDKGFAEAVSEITGLSFKTAPNKFEALASHGAVLNFHGSLNALAADLFKIANDIRFLGSGPRSGLGELSLPENEPGSSIMPGKVNPTQAEAMTMVATQVFGNQTAVTVAASQGHFELNVFKPVIAYNVLQSIRLLSDTMVSFADHCVEGIEPNTARIKELLERSLMLVTALAPAIGYDNAARIAKTAHKNGTTLREEALASGLVSEEDYDRLVRAERMIAPQ
>NZ_CP016980.1|WP_002966391.1|179044_179446_-|DoxX-family-protein
MSSITPKANGAATLIIRVFLSVLFIIAGYNKLTALDGTADYFASIGLPMPIVTAVVVGLIEFVGGLAILFGFKTRIAAVIVGLFTLGATLVAHMDFAEGMNLLIAQKNLAIAGGLFLLFLHGAGSLSIDARRG
>NZ_CP016980.1|WP_002966392.1|177520_178759_-|sugar-MFS-transporter
MATSIPTNNPLHTETSSQKNYGFALTSLTLLFFMWGFITCLNDILIPHLKNVFQLNYTQSMLIQFCFFGAYFIVSLPAGQLVKRISYKRGIVVGLIVAAIGCALFIPAASYRVYALFLGALFVLASGVTILQVAANPYVTILGKPETAASRLTLTQAFNSLGTTVAPVFGAVLILSAATDATVNAEADAVRFPYLLLALAFTVLAIIFAILKPPDVQEDEPALSDKKEGSAWQYRHLVLGAIGIFVYVGAEVSVGSFLVNFLSDPTVAGLSETDAAHHVAYFWGGAMVGRFIGSAAMRYIDDGKALAFNAFVAIILLFITVATTGHIAMWSVLAIGLFNSIMFPTIFSLALHGLGSHTSQGSGILCLAIVGGAIVPLIQGALADAIGIHLAFLMPIICYAYIAFYGLIGSKS
>NZ_CP016980.1|WP_002966393.1|176752_177448_+|ATP-phosphoribosyltransferase
MSVTLALPSKGRLKEKTLAVLEKAGYKVVLPDDDRNYRARVEGEDDLDILFLSASEIARELGYGSVDLGVTGEDLVRETLAHADERVAIEAQLGFGHADVVVAVPEVWRDVTTMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGSADMIVDITSTGSTLRANRLKVLEDGIILRSQACLVSARRSHTSRRVEEIAARIRAGLEI
>NZ_CP016980.1|WP_002972153.1|175625_176756_+|ATP-phosphoribosyltransferase-regulatory-subunit
MVGSRTSPIFNALRVELNAREAELVEIPLIQPADPFLDMAGEDLRRRIFLTENENGDSLCLRPEFTIPVCRNHIALNAATPKRYAYLGEVFRQRRDGAAEFLQAGIEDLGAADEAASDARSLADALSCVKAIAPDAPLEIVLGDQSVFAGMLKALGLPQGWRKKLLRSFGDAHSMDLALAELTGTQRRDPLPESLAVLVAEGDEIGLARMLEAEMLEAGISPGAGRTPVEIARRLIEKEDLAATHFPAAALDLLRQFLAIRVSLDMAAVTLRAFAADNALDLGAVLQKFEARADAIAQAGIEMKDIIYDASFGRPLDYYTGLVYEIRDASNRQDGVLAGGGRYDRLLTMLGACEAIPGVGFSIWLDRLQALAGEKQ
>NZ_CP016980.1|WP_002968826.1|174108_175617_+|histidine--tRNA-ligase
MADKADKMKARLPRGFVDRVPDDLRAAEKMMATIREVYDLYGFEPVETPLVEYTDALGKFLPDQDRPNEGVFSFQDDDEQWLSLRYDLTAPLARYVAENFETLPKPYRSYRNGWVFRNEKPGPGRFRQFMQFDADTVGAPNVSADAEMCMMMADTLERLGIQRGDYAIRVNNRKVLDGVLDAIGLEGEGNAAKRLNVLRAIDKLDKFGPEGVRLLLGKGRLDESGDFTKGAQLPEAAIEKVLAFTAAGGADGAQTIANLQAVVAGNAKGEEGVQELADMQALFFAGGYEGRVKIDPSVVRGLEYYTGPVFEAELLFDVTNEDGQKVVFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSRLMTALKNLGKLDVSDTVGPVVVLVMDKDTQNLGRYQKMVSDLRKAGIRAEMYVGGSGMKAQMKYADRRAAPCVVIQGSQEREAGEVQIKDLVEGKRLSAEIEDNVTWLESRPAQITVREDGLVDAVREILDAQARDRAEQSK
>NZ_CP016980.1|WP_002966396.1|173380_173998_+|LysE-family-translocator
MDLMSLVAFAGILVVAAGTPGPKVGALVARVISRGHKGVFPFMFGLWLGDAVWLSLAVWGLSALAHTFQTAFLVLKYAGVAYLIYLSWKMWFAPVDEEADENTIPRQGEGKRLFLSALGVTLGNPKIMVFYLAILPTVVDITHVSLTGWVELLLVMFMVLAAVDTAWVVLAAQARKFLRSPRMMRLANRTSAGMMAGAAVAIAAR
>NZ_CP016980.1|WP_002967189.1|172605_173262_+|DNA-3-methyladenine-glycosylase-I
MSDMAEARAGLVVGADGRTRCFWPGELPDYLAYHDNEWGVPVADDFRLFEKICLEGFQSGLSWLTILRKRENFRAAFDGFNFHRIATYDESDVERLLADKGIVRHRGKIVSVINNAGRAIELIEEKGSLAAYFWSFEPGAENRPAVVDYPTLVANPITATSTRISKDLKKRGWSFVGPTTVYAFMQAMGLVNDHIEGCHCRATIEKLRQNFKRPGKKL
>NZ_CP016980.1|WP_002968994.1|170529_171357_-|aldo/keto-reductase
MTVPTVKLNDGNHIPQLGYGVWQISNDEAVSAVSEALKAGYRHIDTATIYGNEEGVGKAINGSGIARADIFLTTKLWNSDQGYESTLKAFDTSLKKLGTDYVDLYLIHWPMPSKDLFMETWRAFIKLKEEGRVKSIGVSNFRTADLERLIKESGVTPVLNQIELHPQFQQDELRLFHGKHDIATEAWSPLGQGKLLEDPTLKSIAEKHAKSVAQIILRWHIETGNIVIPKSITPARIKENFDIFDFTLNGTDHDAITKLDMADGRIGPNPSVFSA
>NZ_CP016980.1|WP_002966386.1|183827_184124_-|co-chaperone-GroES
MADIKFRPLHDRVVVRRVESEAKTAGGIIIPDTAKEKPQEGEVVAAGAGARDEAGKLVPLDVKAGDRVLFGKWSGTEVKIGGEDLLIMKESDILGIVG
>NZ_CP016980.1|WP_002972147.1|184604_185453_+|TIGR01459-family-HAD-type-hydrolase
MILPERLDDLTDRYDAIFCDVWGVVHNGETSFAPAIAALQRARAKGVTIILVTNSPRPHPGVVAQMSLLGVPEDAYDRVVTSGDVTRDLIAEGPRRIFHIGCERELAIYDGLDVELVEEFEAAGVVCTGLYDDEVETPEDYRELLQRLRARNLPFICANPDIMVERGPRLIWCAGALAREYGQLGGRTLIAGKPHRPIYEAALRAVESIRGGSVDKSRILGIGDGVLTDVKGAADFGLDVLYISGGVHAADYAVNGDLDMAKMEAFLEKHGHRPIASLHALV
>NZ_CP016980.1|WP_002966383.1|185540_186530_+|bifunctional-riboflavin-kinase/FAD-synthetase
MKKSSFQRLTGTEGLPPALHDCVVAIGNFDGVHRGHQAVLERALELAERESRPAVVLTFEPHPRSFFKQDQPVDRLTDAAEKAEILRLMGFDAVMEQPFTAEFSQRSAEDFVQHILVEKLRASRVVTGYDFHFGKGRRGTPEFLCEAGKKAGFSVTLVDAFTDEGGMLVSSTRIRNLLSEGEVAEAAGLLGYRYRICGEVIHGKKLGRTLGFPTANMALAPQTSLKHGIYAVRFRLDDAMLYDGVASFGRRPTVDDEGAPLLETFLFDFSGDLYGKTAAVSFFGFLRGEVKFDGLDPLIDQMKQDEAQARALLADVRPISGLDRMLSFN
>NZ_CP016980.1|WP_002966382.1|186873_189792_+|isoleucine--tRNA-ligase
MTDTTKIDYSKTLYLPQTEFPMRAGLPQREPLFVQRWEEMNLYKKLREQAKDRPLYVLHDGPPYANGNIHIGHALNKILKDVITRSFQMRGYNSNYVPGWDCHGLPIEWKIEEKYRAAGKNKDEVPINEFRKECREFASNWIKVQTEEFKRLAILGDFENPYTTMNFHAEARIAGELLKFAASGQLYRGSKPVMWSVVERTALAEAEVEYHDIESDMIWVKFPVAGEVATENDLSGSAVVIWTTTPWTIPGNRAVSYSSRIEYGLFEITEAENDFGPRPGERLVFADKLVEECCAKAKLQFKRLRSVSAEELGKIVLDHPLKGFGGGYEFVVPMLDGDHVTDDAGTGFVHTAPSHGREDFEAWMDNARQLEARGIDPNIPFPVGDDGFYTKDAPGFGPDREGGPARVIDDNGKKGDANKVVIEQLIAADKLFARGRLKHSYPHSWRSKKPVIFRNTPQWFVYMDKNLGDGTTLRSRALKAIDETRFVPAAGQTRLRSMIEGRPDWVLSRQRAWGVPICVFVDEEGNILQDDAVNKRIMDAFEKEGADAWFADGARERFLGARAGEGWTQVRDILDVWFDSGSTHTFTLEDRPDLKWPADVYLEGSDQHRGWFHSSLLESCGTRGRAPYNAVVTHGFTMDEHGKKMSKSLGNTVTPQDVIKESGADILRLWVMTTDYWEDQRLGKSIIQTNIDAYRKLRNTIRWMLGTLAHDEGENVAYADLPELERLMLHRLTELDELVRSGYDTFDFKRIARALVDFMNVELSAFYFDIRKDALYCDAPSSIRRKAALQTVREIFVRLTTWLAPMLPFTMEEAWLDRYPQSVSIHAEQFRPTPAEWRDDVLAEKWRKVRAVRRVVTGALELERADKRIGSSLEAAPVVYIADKSLSDSLEGLDFAEICITSGISVSDAAAPEGAFTLGDVKGVAVVPERAKGEKCARSWRYTTDVGADPEFPEVSARDAAALRELQALGKL
>NZ_CP016980.1|WP_002971287.1|189983_190655_+|hypothetical-protein
MKIEGRVLVLMTALAGLSLSGCVSSPTYGTDKSAGAQLLDDVSNMASFGQGKKKERIDYKPRPDLVRPAPGDKGYLPAPQQSLASSSDPNWPESPEQRRKRVRDEITAHRDDPNYVSPVLQDAPVADNIRTALPRGNSRREDYASRTPTSDPAKVAALKAARAQQNQGSATTRRYLSEPPLAYRQPASTAAVGELGPDEAQKERERKKAASGSRGWRDYLPWN
>NZ_CP016980.1|WP_002967192.1|190999_191560_+|cytochrome-b
MSSKTYIWDDRSGYGLVSRGFHWLMALLFLWQFASAILRVFAKDTPIYSFFWSAHFQLGFALLVLALLRGVWGLMNIHRRPHKDGAIGKLAVLGHLAIYVLMITIPSLALLRAYGSGRGFSFLGMPIFAKTDIQNAMLTAPANALHGPLGWALLAAIVGHVAMALVYHFALRDDTLRYMTGHGTPN
>NZ_CP016980.1|WP_002966379.1|191613_192087_-|nucleoside-deaminase
MRKAASITKANSATPMDIALEEAHAAGERGEVPIGAVIVRDGEIIARAGNRTREFNDVTAHAEILTIRQAGEMLGSERLIDCDLYVTLEPCAMCAAAISFARIRRLYYGASDPKGGGIEHGGRFYTQPTCHHAPEIYPGFCEADARKILKDFFREKR
>NZ_CP016980.1|WP_002966378.1|192227_193973_+|pseudouridine-synthase
MMAQGDAVTLLKGLYQMTTEDDNKGGKPPHGRKGHSDRPGRPDWDSRPRREGGDRDKPRKFGSRGAPVEEETSERIAKRLARAGIASRREAETMIAAGRIAVNGKVLESPAVNVKRTDIITVDGKPLRQTERTRLWLYHKPAGLVTTNRDPEGRPTVFEALPPEMPRVLSVGRLDINTEGLLLLTNDGGLSRVLELPSTGWLRRYRVRAHGKVTQQQLDELKNGIAVDGVFYGSVEAELERVQGANVWISIGLREGKNREVKNILGALGLTVGRLIRVSFGPFQLGDLEEGAVREIKGRTLRDQLGDKLIEESGADFDAPVLNEFSNAAVQGRTRREMEEGELPQEGERRRAPREREWISSTGERRRGREEKTEKVEPRRRGNANVWMAPGARPKGEKEAAKPARVEHQQPHRSAKFSGDLQMRPRRFSEEERGGEESGERRYKRPEGRFEREGGRPDNREKYEKHEGAGKERRPGKRERAELRNAEGQTTERGKGGFEGRKPGKPGGPRSEGRFGGADRDTRSGPRGSGPRGAGDGPRRGHDGKPGGKPGGKPTGRPGGKPGTKPGGGGRSGGGGADRRR
>NZ_CP016980.1|WP_002966377.1|193953_194517_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MRIVGGKFRGRALVTPSTNAIRPTTDRTRESLFNILAHSFPDKVEGVRVLDLFAGTGALGLEALSRGARYATFVEESAEGRGILRQNIEALGLQGHTKILRRDACQLGIVGTMEPFDLVFADPPYGRRMGEKAFLSALQGGWLNPDALLVLEEDAQAALELDDRFAVREERNYGGTVIRLIELKAAS
>NZ_CP016980.1|WP_002969286.1|194602_196147_+|insulinase-family-protein
MNTPHSGCLLLSTVLGFALALPLAGGAVRAEMQPAAPAETQPAPAAPAAPVAPAALPEIFRLDGVSNFTLPNGMQVVVIPDHRAPVVTQMVWYHVGAADEAPGVSGIAHFLEHLMFKGTKNHPAGEFSARIASIGGQENAFTSYDYTAYFQRVSPEALEMVMDFESDRMENLVLDEEAVKTEREVILEERRMRIDSNPGAMLMENTDAVLFYNHPYRKPVIGWQQEMEKLSLKNAIDFYNQYYTPNNATLVIAGDVTPERVRELAMKTWANVHKRAEVLLRERPQEPAKHAARVVTLHDERVSTPSFRISWLVPSYANEKRFANAKPGDAPALDLLSEILGGSQLSQLYQQLIVKQGIAAETGASYDGDALDDGTFSVYGVPRNGASLGDVEKAVAAQVDRIIRDGVTQAELDQARNRFLKAVIFARDSQTGMARIYGSALSVGQTVDDIQKWPDLIKSVTVDQIKDVARRYLVKDQAVTSYLLPPDTEAESARKKPNAPANDASASGAGGAIQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP016979

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CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP016980

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection