CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP016431	Bordetella bronchiseptica strain I328 chromosome, complete genome	7 crisprs	csa3,WYL,DEDDh,cas3,DinG	1	3	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016431_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016431_1

843188-843294

Orphan

Consensus_repeat	Method
GATGGTGCCTGGGGAGCCAGGCACCGGAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016431_1

>merge|NZ_CP016431|1|843188-843294|CRISPRCasFinder
GATGGTGCCTGGGGAGCCAGGCACCGGAGGAAGTCAGCCGGAGCCTGGCTCCCGTGGGGCGTTGTGGGCCCGCGGGAGATGGTGCCTGGGGAGCCAGGCACCGGAGG

>NZ_CP016431|1|1|843188-843294|CRISPRCasFinder
GATGGTGCCTGGGGAGCCAGGCACCGGAGG	AAGTCAGCCGGAGCCTGGCTCCCGTGGGGCGTTGTGGGCCCGCGGGA
GATGGTGCCTGGGGAGCCAGGCACCGGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016431.1\|WP_068925031.1\|846198_847107_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176148
NZ_CP016431.1\|WP_033466455.1\|850987_852874_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP016431.1\|WP_033466480.1\|836898_837510_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP016431.1\|WP_094771198.1\|841145_843107_+\|LTA-synthase-family-protein	unknown	unknown	gnl\|CDD\|224287
NZ_CP016431.1\|WP_068925027.1\|843297_844611_-\|fumarylacetoacetase	unknown	unknown	gnl\|CDD\|162276
NZ_CP016431.1\|WP_068925029.1\|844717_846016_-\|homogentisate-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|235421
NZ_CP016431.1\|WP_033466463.1\|847116_847326_-\|DUF2783-domain-containing-protein	unknown	unknown	gnl\|CDD\|371304
NZ_CP016431.1\|WP_068925023.1\|839742_841065_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP016431.1\|WP_068925033.1\|847337_849017_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|236158
NZ_CP016431.1\|WP_033466476.1\|839035_839746_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP016431.1\|WP_033466453.1\|852870_853470_+\|lipoprotein-localization-protein-LolB	unknown	unknown	gnl\|CDD\|234578
NZ_CP016431.1\|WP_033466482.1\|835236_836619_-\|phosphomannomutase/phosphoglucomutase	unknown	unknown	gnl\|CDD\|100091
NZ_CP016431.1\|WP_068925035.1\|850161_850989_-\|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	unknown	unknown	gnl\|CDD\|234899
NZ_CP016431.1\|WP_033466491.1\|830256_831378_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340847
NZ_CP016431.1\|WP_094771197.1\|831374_832529_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340836
NZ_CP016431.1\|WP_033466484.1\|833663_835229_-\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234679
NZ_CP016431.1\|WP_068925021.1\|837602_839018_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_CP016431.1\|WP_033466450.1\|853517_854417_+\|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	unknown	unknown	gnl\|CDD\|234731
NZ_CP016431.1\|WP_068925019.1\|832525_833656_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340837
NZ_CP016431.1\|WP_033466459.1\|849118_850072_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293840

Protein	Function_ID	Function_description	E-value
NZ_CP016431.1\|WP_068925031.1\|846198_847107_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176148	cd08459, PBP2_DntR_NahR_LinR_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold. This CD includes LysR-like bacterial transcriptional regulators, DntR, NahR, and LinR, which are involved in the degradation of aromatic compounds. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. DntR from Burkholderia species controls genes encoding enzymes for oxidative degradation of the nitro-aromatic compound 2,4-dinitrotoluene. The active form of DntR is homotetrameric, consisting of a dimer of dimers. NahR is a salicylate-dependent transcription activator of the nah and sal operons for naphthalene degradation. Salicylic acid is an intermediate of the oxidative degradation of the aromatic ring in soil bacteria. LinR positively regulates expression of the genes (linD and linE) encoding enzymes for gamma-hexachlorocyclohexane (a haloorganic insecticide) degradation. Expression of linD and linE are induced by their substrates, 2,5-dichlorohydroquinone (2,5-DCHQ) and chlorohydroquinone (CHQ). The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.88079e-71
NZ_CP016431.1\|WP_033466455.1\|850987_852874_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	1.37052e-18
NZ_CP016431.1\|WP_033466480.1\|836898_837510_+\|hypothetical-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	3.82507e-06
NZ_CP016431.1\|WP_094771198.1\|841145_843107_+\|LTA-synthase-family-protein	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	5.34076e-83
NZ_CP016431.1\|WP_068925027.1\|843297_844611_-\|fumarylacetoacetase	gnl\|CDD\|162276	TIGR01266, fum_ac_acetase, fumarylacetoacetase. This enzyme catalyzes the final step in the breakdown of tyrosine or phenylalanine to fumarate and acetoacetate. [Energy metabolism, Amino acids and amines].	2.78402e-171
NZ_CP016431.1\|WP_068925029.1\|844717_846016_-\|homogentisate-1,2-dioxygenase	gnl\|CDD\|235421	PRK05341, PRK05341, homogentisate 1,2-dioxygenase; Provisional.	0
NZ_CP016431.1\|WP_033466463.1\|847116_847326_-\|DUF2783-domain-containing-protein	gnl\|CDD\|371304	pfam10932, DUF2783, Protein of unknown function (DUF2783). This is a bacterial family of uncharacterized protein.	4.00804e-29
NZ_CP016431.1\|WP_068925023.1\|839742_841065_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.6207e-35
NZ_CP016431.1\|WP_068925033.1\|847337_849017_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|236158	PRK08132, PRK08132, FAD-dependent oxidoreductase; Provisional.	0
NZ_CP016431.1\|WP_033466476.1\|839035_839746_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.88249e-66
NZ_CP016431.1\|WP_033466453.1\|852870_853470_+\|lipoprotein-localization-protein-LolB	gnl\|CDD\|234578	PRK00022, lolB, lipoprotein localization protein LolB.	8.51454e-50
NZ_CP016431.1\|WP_033466482.1\|835236_836619_-\|phosphomannomutase/phosphoglucomutase	gnl\|CDD\|100091	cd03089, PMM_PGM, The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a bisphosphorylated sugar intermediate. The reaction involves two phosphoryl transfers, with an intervening 180 degree reorientation of the reaction intermediate during catalysis. Reorientation of the intermediate occurs without dissociation from the active site of the enzyme and is thus, a simple example of processivity, as defined by multiple rounds of catalysis without release of substrate. Glucose-6-phosphate and glucose-1-phosphate are known to be utilized for energy metabolism and cell surface construction, respectively. PMM/PGM belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the phosphoglucomutases (PGM1 and PGM2). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP016431.1\|WP_068925035.1\|850161_850989_-\|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	gnl\|CDD\|234899	PRK01103, PRK01103, bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase.	3.67058e-154
NZ_CP016431.1\|WP_033466491.1\|830256_831378_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340847	cd03820, GT4_AmsD-like, amylovoran biosynthesis glycosyltransferase AmsD and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.	4.80172e-144
NZ_CP016431.1\|WP_094771197.1\|831374_832529_+\|glycosyltransferase	gnl\|CDD\|340836	cd03807, GT4_WbnK-like, Shigella dysenteriae WbnK and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.	6.9492e-113
NZ_CP016431.1\|WP_033466484.1\|833663_835229_-\|glucose-6-phosphate-isomerase	gnl\|CDD\|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NZ_CP016431.1\|WP_068925021.1\|837602_839018_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	2.84923e-127
NZ_CP016431.1\|WP_033466450.1\|853517_854417_+\|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	gnl\|CDD\|234731	PRK00343, ipk, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional.	1.48798e-159
NZ_CP016431.1\|WP_068925019.1\|832525_833656_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340837	cd03808, GT4_CapM-like, capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.	2.69613e-149
NZ_CP016431.1\|WP_033466459.1\|849118_850072_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293840	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	5.66516e-73

>NZ_CP016431.1|WP_094771198.1|841145_843107_+|LTA-synthase-family-protein
MRVFFCNEADEAPARPPPTRNPVRRLTIRFAIAILVLLTLSRLGLSAWQWDRVQAAGGLGPIMLGGLRMDLRLLALVLALPAVLAPWFGHRAWAATVTAWWYRVWWMLFVLLEVSTPQFIAEYDTRPNRLYFEYLVHPREVASMLWEGYKGVLLAAFVVLVLAAWLAVRLFPTGRQDGFMKWWKRPFVTLAVLAVVVLAARGTLQHRPINAAMVAFSSDAMVNTLPLNSLGNVLDAAYRLQDERSSAALYPPMKTEEMNRIVRAVAGLEDPPLDARYPSLHKQIATVRRDKPLNLVIILQESLGAQYVGSLGGRDLTPQLDRLAKDGWMFNRAYATGTRSVRGLEAVTAGFLPTVAEAVLKLPRSQTGFFTLADLLGRHGFHSRFIYGGEAHFDNMRGFFLGNGFNEVIDRQSFVDPVFVGSWGASDEDMFNQLDRLLRADDGKSTFTLAFSVSNHSPWEYPEGRIEPVGDPASVDNTVRYADWAMGQFFDKARKAPYWDNTVFLVIADHDSRVYGANLVPVRHFQIPALILGGTVAPRSDDRIVSQIDMGPTLLSLIGLDNVNPMLGADLTQRDPNRAIMQYGDNFGYLKGDSLLVIEPGKDPREYRYTAAASMSDEKYAPIDIDPALRDEALAFALWPSWAYREERYKLPK
>NZ_CP016431.1|WP_068925023.1|839742_841065_+|HAMP-domain-containing-histidine-kinase
MSSRPVSGNGAGSLTQRVVWALTGSVALFVTALVLLSYLTFDKMEDDLVNDILSTETDRLIQHVAADDHFLPERGARELGGAMRAWLVRAGAAQPDLPQALHGLGVGMHLLEPGAETWHVMVAEVEGARIYVLYDATDNEARVHDFGLFVLGVGAICIVAAYGISRRVAGVAVGPLVELTRRLANWAPGAPDLAVTRDDEAGRLVEAFNRGQNQVDRSIAREREFSVNLSHEVRTPLAAIRSDSEMMLLAATLDAGQRTRLARIVANVDNVSAALESARAMARDEPRAPERVDLAACMDDAWRGLELNAEAAGLAFANRIPAGSEHVLDRYAMLTVLRNLVRNAIEHAAPATLTAALRPDGALELRDDGRGIAAEELPFVFQRFYSGRLRDTADNGSHELPRGLGLAIAKRVCDMQGWRLSVDSERDGPARGTRFVLRFT
>NZ_CP016431.1|WP_033466476.1|839035_839746_+|response-regulator-transcription-factor
MSATPASRHYRILIVEDDLTIAANLYDYLQARGFVPDAAYDGRSALALLDEHGFDAMVLDVGLPGMDGHAVLHAVRVERRAALPVLMLTARDGLDDKLAGFAHGADDYLTKPFALAEVEARLLALIQRSRGAVVDSLRSFGPLQFDSATREVAVHGKPVHLTRKCGMIVEALLRDPGRVVSREQLETALWGDDPPSSDALRSQVHLLRRALADAGFDGIETVHGTGWRLTLPAGGA
>NZ_CP016431.1|WP_068925021.1|837602_839018_+|FAD-binding-oxidoreductase
MTLPSELQALLGPSHVLTGDDAEPFLLDWRRRYRGRALAVVRPGSAEEVAAVVRLCQAHGAPLVPQGGNTGLCGGATPDDSGSAVVLSTTRLNRVRAIDTDNDTITVEAGCVLQAVQQAAEQAGRLFPLSLAAEGSCTIGGNLATNAGGTQVLRYGNARELTLGLEVVTAEGEIWNGLRGLRKDNTGYDLRDLYVGSEGTLGIITAATLKLFPLPVATCTALLALDSIDAAVEVLSRARGGFGASLTGFELMAADCLQAVTRLFPQQRLPFDGASAQAPWFALLELSDSESEEHARARFEAVVGAAIEDGLVADAAIAENLAQSQALWHLRESIPLAEAELGKSIKHDVSIPISAIAAFVHQTNGLLQARFPGVRNVIFGHLGDGNLHYNVARGPGQTEADLLALQSRVYDVVHDSVQAFAGSISAEHGVGQLKRDELPRYKSAVELALMKRLKTALDPRGLLNPGKVLQA
>NZ_CP016431.1|WP_033466480.1|836898_837510_+|hypothetical-protein
MSADISFVSTRRRMAPGRVDLAAGGERRLDIPVHAGVDGSVEAGRAWERCVWRAARVLIAECPAPRLSARLEETLRGVAVRIARDRGWCGIGTVVFSLDVGTGMFRMIEARLCGLQQGEPAADAASGGHALEVRISACADSGRRGAHLLTYGATRGEALRRAYQALAKLPGLAQADRAFLMDRIASPAFCSGLTGSQLDRIAS
>NZ_CP016431.1|WP_033466482.1|835236_836619_-|phosphomannomutase/phosphoglucomutase
MAHPFPASVYKAYDIRGSVPDQLDPVFARALGRALAASARAQGIGALVVGRDGRLSSPDLAGALQEGIMEGGVDTLDIGQVPTPLVYFAAHTQGTGSGVAVTGSHNPPQYNGFKMMMGGHALYGPAVQALRPAMLAPAPAPGTWGERRQLDVVPAYVERIVSDVKLARPMKIAIDCGNGVAGALAPQLFRALGCDVDELYCEVDGTFPNHHPDPAEPRNLQDLIAHVTGTDCELGLAFDGDGDRLGVVTKSGQIIWPDRQLILFARDVLARCPGATIIYDVKCSRHVGVAIEQSGGVPLMWQTGHSLVKAKLAETGAPLAGEMSGHIFFKERWYGFDDGLYTGARLLEIVSREADASRPLEALPQALSTPELKLEMAEGEPHALIAALQQQGEFASASRLVTIDGVRAEYPDGFGLARASNTTPVVVLRFEAETEPGLARIQQEFRQQLLRLAPQAKLPF
>NZ_CP016431.1|WP_033466484.1|833663_835229_-|glucose-6-phosphate-isomerase
MPTPLPSSSAWLAFADAARHSSRRGARLRIIEAAGLRVDLTAQAHSDDLDSAAEDLLAQQDFDNARAQLFDGGQANWTEHRPAWHTALRAARPPAPVAGAILGERDRLRRFVQDADMRGAYRHVLHLGIGGSDWGPRMVTRALRHNGLKREVRFASNVDSHAVADALHHLDPHDTLIIVASKSFTTTEPLANAEVAMNWLRNAGVADPVRQVVAITANVDAALDFGISPQHIFRFWDWVGGRYSLWSAIGLPVALALGCDALDELLAGAAAMDQHFLHTPMRRNAPLQMALAGVANRSVLGYGSLAITPYDSRLTHLVPWAQQLEMESLGKVAGHDGSPAGVPTGPVVWGMTGTDCQHTFFQWLHQDTAGAPVDFIVCEQADHPYDHFHKLLIANCLAQRAALLRGKPFDEALKEARLVESDPQQAEILAHHRVHPGGRPSTLVMLPRLSAHALGALLAMYEHKVFAQGVLWGINPFDQWGVEYGKALARNIIRELENPSSEVNQQDPSTRYWIDALRKQP
>NZ_CP016431.1|WP_068925019.1|832525_833656_+|glycosyltransferase-family-4-protein
MTPPRRLLFVVNNPAFFLSHRLPLAEAARADGYEVHVATMDGPSVPDIVARGFTHHAIPMTRSGKQPLQELRSVWALARLFRRLRPGLVHLVTIKPVLYGGIAARLAGVPAMVAAISGLGFVFVAGGLKGRLLRAAVGRLYRLALGHRNSRIVFQNTADRDVPARLGAVRAEQVVMIRGSGVDLGQYRVVPEPAAPVTALMAARLLRDKGVREFVEAARLLRERGLAVRMQLAGGVDPGNPASITPEQAAQWRDEGCVEMLGERKDVAALYGAAHMAVLPSYREGLPKSLLEAAACGRAVVTTDVPGCRDAIDPGVTGLLVPPRDAPALAEAIARLAEDASLRQRMGAAGRALAEREFGIEDVCRRHLAIYRALTR
>NZ_CP016431.1|WP_094771197.1|831374_832529_+|glycosyltransferase
MTRILRVMHVITGLGQGGAESVLFRLAAWPDQRVRHSVISLTDEGVYGTRLRAAGVPVHALGMPRGRVTLAGMLALRALLRRERPDAVQTWMYHADLIGGVAARLAGIRAVAWGIRNSGEHLDRSSRSARLVLKLCARLSARLPAAIVCAAQDAATRHRQHGYDGARMVVIPNGYDLSRYAPDAQARERVRALWGVAPDTPLVGCVARWDPLKDHANLLAALGGLVREGRDRGLQCALVGRGMSPGNEGLAALIDAEGLRGRVLLAGPSDDVPAVMNALDLHVLSSCAEGFPNVVAEAMACGTPSVATDVGDAAYIIGDTGRVAPAQQPAALAAAIAAALAEIAAHGREAAGAAGRQRVLAEFDLRRMVESYEAVWRRISGERA
>NZ_CP016431.1|WP_033466491.1|830256_831378_+|glycosyltransferase-family-4-protein
MKILLLVSSMHAGGAERVAATLANGWAARGDQVTLMPTYSSKGTCFYPLSDDVELLWLADRAGTRSGGVVAAWQRLRALRAVVRERAPDVVVSFLTNVNVAAILATRGLKTPLIVCERTNPVVDTSIGRVWRLLRRVLYPLADMVTVQADATVEPFARQVPGLKQLCVIPNPLPPELFDAAPATGSGAAPAVRKRLMAMGRMVPDKRFDLLIDAYAGLADEFPDWDLWIWGEGPLRDDLQAQVAARGLATRIHMPGRTTAPWDELAKADAFVLSSAVEGFPNVLLEAMSLGLPCAAFDCPSGPAEMTRGGRDALLVPAGQRDALRDALGRLMRDPGLRRDLGRRAAQSVRQRYALPAVLAQWDALFERVRGGA
>NZ_CP016431.1|WP_068925027.1|843297_844611_-|fumarylacetoacetase
MSKLNETHDPALQSWVASANAADTSFPIQNLPYAAFRRKGTQEPFRPGVAIGEAIVDLAALAAQAPFDGAAAAALAACQGERLNALMALDQAHWSALRLALSRALRAGSALQARIEPLLVAQAEAEYTTPAHIGDYTDFYISVHHATAVGKQFRPDNPLLPNYKWVPIGYHGRASSIGVDQRFARPVGQTRPAAEGQAPQFGPCQRLDYELELGIFVGRGNAQGERIALGEAESHVFGLCILNDWSARDIQAWEYQPLGPFLAKNFASTISPWIVTLEALEPFRTAWTRDAADPQPLPYLESAENRAHGAFDVQMEVLISTEQSRAKQAQPALLSRSNFRDAYWNVAQLVAHHTVNGCNLQPGDMMGTGTLSGPQASEAGSLLELTNGGKQPLDLPWGEQRTFLQDGDQIIMRAECSKPGYPRIGFGDCVGTVLAAK
>NZ_CP016431.1|WP_068925029.1|844717_846016_-|homogentisate-1,2-dioxygenase
MSLQYQTGFGNACATEALPGALPAGRNSPQICPYGLYAEQLSGTAFTAPRAENRRSWLYRIRPGVQHLPFAPFAGAQRWLSDFGRQPVTPNQLRWSPLPMPDAPTDFIDGMHTWGGNGSPEEQGGVGIHLYAANRSMQGRFFYNADGEMLIVPQQGRLRLATEMGLIDIEPYEIAVVPRGVRLRVELLDDVARGYVLENFGTAMRLPELGPIGSNCLANARDFQIPVAWYEDVEGDFELIAKFTGGFWRAPITHSPLNVVAWHGTHAPYKYDLRNFNTVGSISYDHPDPSIFTVLTSPSDTPGTANMDFAIFPPRILAMENTFRPPWFHRNIASEFMGLIHGVYDAKAEGFAPGGASLHNCMSGHGPDADTFEKASHADTSQAHYIRDTMAFMFETRRVIRPTAQALASPQRQDDYYQCWQGLQKHFNPEQA
>NZ_CP016431.1|WP_068925031.1|846198_847107_+|LysR-family-transcriptional-regulator
MAELRNIDLNLLVIFQRLLQERSISAVARQLDLSQPAVSNALRRLRAACGDDLFVRTAQGMQPTPHAERLGGPVGEALALLSHALDATQDFDPRASTRRFRIAMSDVGEIHFMPRLMDQCARHAPGVRIDSLRLQGADLQREMDAGRVDLAIGAFADLGGAVMQRMLFRQGYATLYRQGHPSAHEGMGLKAFRAAHHLVVSHATPYGQVNQSLERAGVTLGEHFSVPHFAAVPYIVSTTDLLATVPQKLAASAAPHFGLGLLTPPLRMPTLQTNLYWHRRFQRDSGSQWLRALIVQAFADAP
>NZ_CP016431.1|WP_033466463.1|847116_847326_-|DUF2783-domain-containing-protein
MPLITTPNLAGPDNFYEALIDTHRDLSDEQSRELNAALILLLANHIGDMAVLREALQQARQSVVAPPAA
>NZ_CP016431.1|WP_068925033.1|847337_849017_-|FAD-dependent-oxidoreductase
MGDIDYQAIEFAYTKCADQERDTPARHGVIVVGAGPVGLTTALDLARQGLRVVVLDDDYRLSTGSRAICFAKRTLEIWDRLGVGQRMVDKGVSWNVGKVFFRDQEVWRFDLLPEPGHRRPAFINLQQYYAEGYLHELASAQPGIELRWKSKVVGVAQQADGVQVTVDTPDGAYALHADWLVACDGARSPVRKLLDLETHGRVFKDRFLIADVKMAADYPAERWFWFDPPFHPNQSVLLHMQPDNVWRIDFQLGWNADPVEAVKPENVLPRIRALLGPDADFELEWVSVYTFACERMDHFRHGRVVFAGDSAHRVSPFGARGANSGVQDAENLAWKLRLVLAGHAPESLIDSYAAEREYAADENILNSSRSTDFITPKSEVSRTFRNAVLNLARQHPFARTLVNSGRLSVPAAYADSPLNTPDSDPFAGTMRPGAVALDAPVRADAQPGWWLSQLDGGFALALFCGAETPRADMLDALRALQQDEVPVQPILVCDAGAAPAAAPAGVRVVEDSEGWLARRYDARPGTCYLIRPDQHIAARFRAFDAQAVRRALARAIGRA
>NZ_CP016431.1|WP_033466459.1|849118_850072_-|MBL-fold-metallo-hydrolase
MSKQFASHADLEDKVVSFEKLSDNAYAYTAEGDPNTGIIVGDDAVMVVDTQATPVMAQDVIRRVREVTDKPIKYILLSHYHAVRVFGASAYGAQEILASRDTYDLIAERGEQDKASEIGRFPRLFRNVESIPPGLVWPTMTFKGEMTVDLGNLEVRLLQVGRGHTKGDTIAWLPEQKILFAGDLVEYQSTPYCGDCYFREWPATLDALAGFAAEKMVPGRGPALKSAAEVRQGLAGTRAFLTDLYAAVNRGVADGKDLKTIYREVYDFMKPRYSQWVIFDHCMPFNVSRAYDEATGYNDPRIWTDKRDIEMWKQLEG
>NZ_CP016431.1|WP_068925035.1|850161_850989_-|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase
MPELPEVETTRRGIDTVITGRTLRRLVVREARMRWPIPPALPDLLAGRTVLECGRRGKYLLLRFDHGVQIVHLGMSGSLRRVPEQEAPRKHDHVDWVFDHAILRLHDPRRFGAVLWHPGEAGPVAAHPLLARLGIEPFDPRFDGRWLHAYFRGRRVAIKQALLAGDAVVGVGNIYASESLFRAGIDPRTAAQRVSAARCDRLAAAIRATLSDALESGGSTLRDYVGASGEPGAYFAIHAAVYERAGLPCRVCGTPIRRLVQGQRATYFCPNCQKR
>NZ_CP016431.1|WP_033466455.1|850987_852874_+|tetratricopeptide-repeat-protein
MSQCKIINCVYEDCAINRTGRVKLSLKHINFGVAALALALAGLQSLPAQAAEVRPRDATGPRLIQPSKQPETEVIRLRPGQLPYVSLTADIFYRIVGAELAAQRGMYGTAAATLVTLARETGDPRLARRGLEFQLAGGNLPGALDAARAWSSLAPNDIEASSTELALAAANGETAGLAAALRKRIDTARDKPAAIVQAMGVLSRLNDRRLALRILDESLSDSARKLPAAHLALADVAQAAGDYPRAASEAYAALAADPRSEAAAQRVLEYGAKVDATRAQHQARAFISRNPDARKLRLMLAGQIADGGDYDGALAELQSMARRSPEDFDLMFMQAQLAYKAGRLDQARGYLQQYLDVQNQRQMATAPGATDAGAAAADAHVLLSRIAEDQGRYDEAIRELGRIDDPAMRYSAHMRQATLRARQGRIDDALAMVDRADPQDDEERTLGVLTKAQILRDADQVDRAVAILVAADKAMPDTVEIKYELAMLYERQGRIDQLERLLREVIALDPDHAHAYNALGYTLADRNQRLPEALDLITQALELSPEDPFILDSMGWVKFRMGEPAAAIEYLKRAYALRPEADIAAHLAEVLWVQGERDSATELLRTAYAKDPKNHALLDTMRRLEVRP
>NZ_CP016431.1|WP_033466453.1|852870_853470_+|lipoprotein-localization-protein-LolB
MSACPAPRLPVRWLHAFTLLLLLAVLAGCVSVPKPMAGAGEDAFSRVGRFAITVTESDGRQQAVQGGFAWRDDGGSYLLDLTNPLGSTEARVEGRPGMAVLTRANGERLAAEHPDALAEDALGSPVPVTGLRDWLRGRLMAGAAPDGLQRDAQGRPTAFEQDGWSARLSRYDAQGPQLLVLQRQEPGRRILVRLVITQP
>NZ_CP016431.1|WP_033466450.1|853517_854417_+|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase
MTLYDVPAPAKLNLFLHVVGRRADGYHLLQTVFRFIDLADTLHFEARADGAIGRAYELPGVAESDDLVVRAARSLQQATGTRQGAQIGLRKRIPQGGGLGGGSSDAATTLIALNRLWGTGLSRSQLMRLALPLGADVPVFVFGQSAFAQGVGEDLTAVALPPAAYLVVQPDAGVPTAAVFSDPDLTRDSASVTIADFLALPTSCFGRNDLEPVVLRRYPEVSGSVRWLVEHGLRVRMSGSGACLFAEFPTLPEAVLAQEEITATMRVAGKTTSLTHPGFRLVQASTGLTEHPLRNWIAS

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Crispr_ID: NZ_CP016431_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016431_2

1137993-1138085

Orphan

Consensus_repeat	Method
CAGGCACCCGCGGCATGCAGCCTGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016431_2

>merge|NZ_CP016431|2|1137993-1138085|CRISPRCasFinder
CAGGCACCCGCGGCATGCAGCCTGCTGCTTGCCGCGGCCCGCGTGGCGGGAGCCAGACACCCTCTCCAGGCACCCGCCGCATGCAGCCTGCTG

>NZ_CP016431|2|2|1137993-1138085|CRISPRCasFinder
CAGGCACCCGCGGCATGCAGCCTGCTG	CTTGCCGCGGCCCGCGTGGCGGGAGCCAGACACCCTCTC
CAGGCACCCGCCGCATGCAGCCTGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016431.1\|WP_068925247.1\|1139755_1140259_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NZ_CP016431.1\|WP_068925241.1\|1129038_1130205_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NZ_CP016431.1\|WP_050458146.1\|1139070_1139766_+\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NZ_CP016431.1\|WP_068925250.1\|1140255_1141488_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340968
NZ_CP016431.1\|WP_033447129.1\|1128520_1129042_-\|acyl-dehydratase	unknown	unknown	gnl\|CDD\|239530
NZ_CP016431.1\|WP_033447495.1\|1144911_1145613_-\|riboflavin-synthase	unknown	unknown	gnl\|CDD\|183846
NZ_CP016431.1\|WP_033447166.1\|1134396_1135446_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP016431.1\|WP_033464717.1\|1142490_1143462_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP016431.1\|WP_033447147.1\|1141435_1142338_-\|transcriptional-regulator-GcvA	unknown	unknown	gnl\|CDD\|182990
NZ_CP016431.1\|WP_033447124.1\|1126873_1127614_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP016431.1\|WP_033447497.1\|1145922_1146912_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP016431.1\|WP_033464715.1\|1143500_1144874_+\|amidase	unknown	unknown	gnl\|CDD\|223232
NZ_CP016431.1\|WP_033447139.1\|1133410_1134385_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP016431.1\|WP_068925243.1\|1131247_1133356_+\|acetate--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|223972
NZ_CP016431.1\|WP_068925245.1\|1136084_1137836_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173842
NZ_CP016431.1\|WP_033447127.1\|1127742_1128519_-\|citryl-CoA-lyase	unknown	unknown	gnl\|CDD\|235748
NZ_CP016431.1\|WP_033447142.1\|1138130_1139000_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|237907
NZ_CP016431.1\|WP_003809010.1\|1147010_1147472_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP016431.1\|WP_033447134.1\|1130234_1130987_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NZ_CP016431.1\|WP_033464725.1\|1135446_1136070_+\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766

Protein	Function_ID	Function_description	E-value
NZ_CP016431.1\|WP_068925247.1\|1139755_1140259_+\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	5.46481e-36
NZ_CP016431.1\|WP_068925241.1\|1129038_1130205_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	9.88796e-111
NZ_CP016431.1\|WP_050458146.1\|1139070_1139766_+\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	2.25503e-19
NZ_CP016431.1\|WP_068925250.1\|1140255_1141488_+\|MFS-transporter	gnl\|CDD\|340968	cd17410, MFS_CynX_like, Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.7743e-95
NZ_CP016431.1\|WP_033447129.1\|1128520_1129042_-\|acyl-dehydratase	gnl\|CDD\|239530	cd03446, MaoC_like, MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.	5.90508e-45
NZ_CP016431.1\|WP_033447495.1\|1144911_1145613_-\|riboflavin-synthase	gnl\|CDD\|183846	PRK13020, PRK13020, riboflavin synthase subunit alpha; Provisional.	9.30426e-109
NZ_CP016431.1\|WP_033447166.1\|1134396_1135446_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	2.02789e-93
NZ_CP016431.1\|WP_033464717.1\|1142490_1143462_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	3.99161e-136
NZ_CP016431.1\|WP_033447147.1\|1141435_1142338_-\|transcriptional-regulator-GcvA	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	2.85654e-93
NZ_CP016431.1\|WP_033447124.1\|1126873_1127614_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	8.31105e-43
NZ_CP016431.1\|WP_033447497.1\|1145922_1146912_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	3.75849e-150
NZ_CP016431.1\|WP_033464715.1\|1143500_1144874_+\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	3.24953e-79
NZ_CP016431.1\|WP_033447139.1\|1133410_1134385_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	9.79009e-121
NZ_CP016431.1\|WP_068925243.1\|1131247_1133356_+\|acetate--CoA-ligase-family-protein	gnl\|CDD\|223972	COG1042, COG1042, Acyl-CoA synthetase (NDP forming) [Energy production and conversion].	1.6895e-118
NZ_CP016431.1\|WP_068925245.1\|1136084_1137836_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	2.32174e-141
NZ_CP016431.1\|WP_033447127.1\|1127742_1128519_-\|citryl-CoA-lyase	gnl\|CDD\|235748	PRK06224, PRK06224, citryl-CoA lyase.	2.59617e-109
NZ_CP016431.1\|WP_033447142.1\|1138130_1139000_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|237907	PRK15092, PRK15092, DNA-binding transcriptional repressor LrhA; Provisional.	2.65005e-43
NZ_CP016431.1\|WP_003809010.1\|1147010_1147472_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	6.17932e-44
NZ_CP016431.1\|WP_033447134.1\|1130234_1130987_-\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	1.02972e-101
NZ_CP016431.1\|WP_033464725.1\|1135446_1136070_+\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	1.25976e-31

>NZ_CP016431.1|WP_068925245.1|1136084_1137836_+|acyl-CoA-dehydrogenase
MSQYRAPWGDIEFLLEHVFARDGQAALDLDLARSVAHEAGKFAQAFLEPVNRRGDQAGARLEQGAVVTPPGFARAYAAFCEAGWNGLRHPERFGGQGLSAVLSTLTEEIWHACNASFALCPMLTGGAIEALLAAADPVLQARLLPRLVSGEWTGTMNLTEPGAGSDLGAVKTRAVARGDGTYAITGQKIFITYGDHDMAANIIHLVLARIPDAPAGVKGLSLFAVPRHLLRDDGSPGEPNRVACVALEHKLGIHGSPTAVMQFGDDEGATGYLVGAPNDGLKTMFVMMNEARHAVGIQGLALSERAYQHAVWYAGERRQGRIVGEDGSRGDTILRHPDVRRLLLGIKSRIDAMRALAIYLALQRDQAHGGAQASPRAAAQARLDLLVPVMKGWFTETAQRATYDAMQVFGGMGYIEETGAAQYYRDARILTIYEGTTAIQANDLVGRKTVRDQGAEARRLLDEIAAAARPGLDGEGLGEALGAACADLRAAVDAILEQAGSAPRAAYAGGVPYLELWGVVAGGWMHALRARAAARLPEARRQAVLASAAFYARHVLPQAAALRQAIVQGGTQADAYPDDCWVG
>NZ_CP016431.1|WP_033464725.1|1135446_1136070_+|flavin-reductase-family-protein
MDAPRTGLDAAGLSARETYRLLTSCLVPRPIAWVSTCDARGTGNLAPFSFYTMVSTVPPLIALSISLHQGQEKDTLANIRQTGEFVVNVVTRELLAPMHACGERHAPGVDEAQLLGVRMRPSQRVRPAGVALSPVRLECRLSQVLEFGVHAARLVVGEVLHFSIDSEYMRDGRLDGARLDPVCRLGGPWYGVLGERLAAPDPSTPST
>NZ_CP016431.1|WP_033447166.1|1134396_1135446_+|CoA-transferase
MTRAAPLAGISVVDFSELLPGPFLTQNLLELGATVVKVERPPHGDNARRLYPGVYASVNRGKRGEMLDLKQAEGRARARELVAGADVLVEGFRPGVMARLGLDYEQARALNERLVYVSLSGYGQDGPQARQPGHDINYLAAAGALALAGSDPAEPAPGAGLPVADLCGAMYALSSTLAALLQRQHTGRGQWLDVALADCVMHWMNPRLGQFASAGLATLAQQRHDVLCKPAYGVFRTADDAHVAIAALEDHFWQALRGALPLAGLAGPLATYREREAQAGPINDALARAVRGRTCQALMEVLTAADVPVSRVELPGELGQSALARQRGLFDAGDGYARYPVRLDHMGAA
>NZ_CP016431.1|WP_033447139.1|1133410_1134385_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MFNKHAFIAALAALAACIAAPAQAAEAYPERPIRFVVPFTAGGITDNVARTVGARAAELLGQPIIVENRAGAGGNIGTEYAANSKPDGYVIFLGTQGTQVTNPLLYTSAPSSADRLQAVQGLTAIPNIVVVNAERPYDTLAKVVDYARANPGKLNNSSAGAGTGTHLAAELFQSVVDVKFSHIPFKGSAPSITALIGGQVDLSFDYPVSTEAYVKAGKIRAVAVTGEARLGSLPDVPTLAELGYPQATSVSWMGVFVPAGTPDAVTARLRQAFAAAIAEPQVAAKLVEFGGVPLQKSGADFTAFVQDEAVKWGKVVKAAGVKLD
>NZ_CP016431.1|WP_068925243.1|1131247_1133356_+|acetate--CoA-ligase-family-protein
MFQNLAPLFAPESLVLIGASDRPASIGQRTLVNIVEHSRFDGELFLVNATKDEVMGRRAYRSVLDLPYAPQTAIVVVSAKAAVEVLAECGRKGVRFAIVLSSGFGETGEAGRQLEEQMRAIVRETGLRIYGPNCPGMTNNNRGLGFTFSPAYQYDRMAGPIGLVTQGGGLGRTFLQACGRGVGIGLWCSSGNEADLTASDYINHMVEMPEIKVIVALLEGINDPPRFARAALNAARQGKPIVALKVGKSAYGVQATQSHTAALSGSAEVNSAAFRQLGIVEVDDIDELIDTAALLARGAPARPIRAAVYSFSGGTVALAADMLGSAGLELSRFEPATRQALAGMLPSYAAIDNPVDTTAEILVQSDISYGSLLCVARDPNVDVVLYPIPMEYGDTTLAACRNMVKAQAEVAVPIVPVWMSDKLGAGFQCLVDAGLTPVRTLGKSVKALAHWNRYGQWMRRFERDWEPSVVKTAAADAAARSEPRAYAEREAKQMLADAGVAVPFGQVCRSADEAVRAAAQCQGPVVAKIVSAQILHKSDIGGVAVGLRTPQQVRDAWETIDANARAACPDARIDGILIEQMIGGPGVETLVGVHEDPLFGHVMTFGLGGVYVEVFKDVSRRLLPLTPQDARDMIRETRCHQLLQGCRGQAAADIEALERLLLAVSGFVVDGPWHIKELDLNPVLAGPAGATALDAVLIGAPR
>NZ_CP016431.1|WP_033447134.1|1130234_1130987_-|SDR-family-oxidoreductase
MDLKIAGKVAVVTGSGRGIGAQTVRTLAEEGARVVVTDINEETARETAARLSADGHEAIGVKCDVCRREDVDALVAAATKAYGGVDILVNNAGFTRDQYLGKMSEDDWDAVVDTIIKGAFHCSRAVLPGMMQKRWGRIVNIASRSVFGNPGQTNYTTAKLGLVGFTRALSLEQAKFGITVNAIAPGFVETELMRSLPTYERLRDGALARNPVGFLGQPGDIADAVAFIASERARYITGVTLYVTGGRFSS
>NZ_CP016431.1|WP_068925241.1|1129038_1130205_-|acyl-CoA-dehydrogenase
MDFDFDSNQQALRDSIRRYLKAEVAPRIDACEAERRIPQDLLQGLAQFGYIGGLLPEDAGGFDLDFVTWAMMVEEAGYCWGSLRTIVNITNIFLRLVQGHGTTRQRERFLAPVLASEKSVCVAISEPNHGSNVAGIECRADDRGDHYLLNGSKLWITNGVNADCAIVLARTYSDTCQGKPSLFLVERAASPYAARLVDKMVLKASGTSELSFDDVRVPKENLLGAEGVALKTMLAGLNYGRLNIAMGAVGAAQAALDLSVEYAKTRRQFGRPIGEFQLIQKHIVDMMVRTEAARALGYKAAAAMQKGQPARIECSIAKLYAAEAAHEVARIALSVHGGLGYSTEYPLERIFRDTSGGIIPEGTAEVQTLIVGREVLGMSAINAAENKA
>NZ_CP016431.1|WP_033447129.1|1128520_1129042_-|acyl-dehydratase
MTVIDTLPPAALEALRYDWEDLEPGLMVESAARTITESDVVSFAALSGDYNRLHTDAVYAGASKFGQRIAHGMLVASIMSGLNTRTVLNQCLEPSILGLLEMTYRFTRPTFVGDTIKVRITVTARRPSSDPGRGVVEFERLGINQHGDTVCACVAKLLVARRAPSPNSQPNEA
>NZ_CP016431.1|WP_033447127.1|1127742_1128519_-|citryl-CoA-lyase
MVKTEIGYTTPERITVRGKDLANELLGQVDFVDMMLMTIFGHLPSAAEKTMVNHILVTACDHGLTPSAMSARLTYLGAPEAMQAAVAAGLLGAGSVFLGTTQNCAEILAAGGAGLAPEAPQEEVDAAARALMAASREKKQPIYGIGHPIHIDGDPRVPTLRRLARELGYYGKHWRLMEAVQRVFLQDKGKNLPMNAVGAVGAIICDMGLDPMIARGLMLVGRAGGLVAHLYEERQDPIGQQLWDLVLAQDPRNVAPAR
>NZ_CP016431.1|WP_033447124.1|1126873_1127614_-|IclR-family-transcriptional-regulator
MPTFVSAAARAMAVFEVFAREKRELSNSDLARLLELPDSSCLDLLHTLHQLGYLLRTQSRRYYPTGKLLQAAQQISTFDLVVHATRDALEQLSQQTGETAYVGRIEGAAVKIVAVREGRYPLRYILNLGERIALHASAMGKALLGRLPPDEARRLLKTKQLRRLTPTTVTEPEDLLEEVLASRERGWYHTRGEGSDGADALAVSGLLSNEPIAIAISGPSDRFSANRDDYVAALRAVAARLFPDDA
>NZ_CP016431.1|WP_033447142.1|1138130_1139000_-|LysR-family-transcriptional-regulator
MLDPVLLRSFVTVVDTGNFTRASEHLHLTQSTVSQHVIRLEENLGCRLLDRGQRHVLPTEEGERLLGYARSILRLADEARESVAAAQGNAVLRLGAPEDFMGAALMPVLAPLLARYPLLRLEFDSGLSHQLLRRYRDGELDLLLVKQWEVDADCQAHWPEPLRWVAARDGPTLPAGEAVPLVVFPAGALYRQEMTRTLEAGGRPWHIRYASTSLAGLVAAVGAGLGVSLLPAASAGSQLRVLRKRDGFAPVDGLQLGLYARARLGAAGRDLRDALAAHCGQRATAMAGA
>NZ_CP016431.1|WP_050458146.1|1139070_1139766_+|ankyrin-repeat-domain-containing-protein
MFKHGGLDMSIIRFYRCWLAAFLVSLGGASVAAGDAGQALLRAAADGDAARVKTLLADGAPLEARDAQGNTPLLRATQGNHVEAAGALVEAGADVNAQNRFQDSAYLLAGARGYRDILALTLAHGADLKSTNRYGGTALIPACERGHVEVVDMLLRAGVDPDHVNRLGWTGLLEAIILGDGGTRHQAIVARLIEGGADVNLADGDGVSPLRHARQRGQAAIVQLLEAAHAR
>NZ_CP016431.1|WP_068925247.1|1139755_1140259_+|nucleoside-deaminase
MRADSNPGVAAPDDDTLLREAIALARANARAGGRPFGALVARDGVVLARGVNRMLADHDPTAHAELLALREAGRALRSARLDGCVVYASGQPCPMCLAAMRMSGVARAVYAYSNEQAEPYGLSTAALAAELELPPQRQPGFAFEHRPGATGPDADLYREWRDGPHAP
>NZ_CP016431.1|WP_068925250.1|1140255_1141488_+|MFS-transporter
MTAARWGAAPRAWAMLALVALIGLNLRPFLTGPGTVLAGIEADTGLGHLGASMLTVLPMLLMGVGALLAPAIQARVGTRRGVLAALLALALGSALRLAAWDGALLVGTAALCGLGVAYIQAVFPGVIKDRFPGRMAAVMGVYSAMMMGGGALGARLTSRLAGGAGDSWRVALAWLAVPALIAFAAAWRCLAETPAARRDGALAGTLMRRPRTWLLIAAFGLVNGGYSSMVAWLAPAVQAQGWSIAQSGDLMVAMTIAQAAAALALPVLAARRADRRPWLYATLSMQAAGFAGMAFWPAAAPLAWAVIGGAGLGGCFALTFIAALDHFSQAEPAGVLAALMQGGGFLIAALAPFAVAALRAATGGFAAGWAMHLACVAIACLLYRRLDPARYARVMAAEPGAAATRRAPSA
>NZ_CP016431.1|WP_033447147.1|1141435_1142338_-|transcriptional-regulator-GcvA
MDGLPPLNAVRTFEVAGRLCSITEAAAELCVTPSAVSRQIRLLEEHLGRKLFVRQHRGVVLTTIGHQYLGDISKALVEVRRATSEAARPRQRAVFTVRAPHSIAMRWLLPRLARFHAAHPHIDVKLHTSLTPPDFEREDLDAGVMLGRGQWKGLVSHMLIRNELIPVCAPHKARALRDPADLADETLLHVFGRPDDWVAWLGAAGVRHVDVQRGMKYESSALAYEAALEGYGIAIAQKALIDKDLQEGRLVTPFDLSVDQGDYTYYFVLPPEGYKRRSPALDTFRRWVRDVSLPRQAPPP
>NZ_CP016431.1|WP_033464717.1|1142490_1143462_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MRLACARWLLACMAPLAGAAAVAETYPARPVTIVVPTTAGGTADILARLIGPKLTALWGQPVVVENRSGAGTLIGTEFAARAQPDGYTLMITYSELATLPALNKNARIDVVKDLTRVGKIGSLPVLILAHPSMPANTMDELVARLRADPGKYTYASNGIGSALQLYTEMFRQAAKVDIMHVPYRGALEASRAVLGGEVDLLVQLGNGNVIGYVTSGKAKAYAVASPQRLAALPDVPTTAEAGLPGLQLEAWYGLFAPAGLPPEQVEKLNRDLATVLAMPEIRDRLVSFGMQVQPGTPQQFDAFFHDEYQRWTRLIEDAGIQIN
>NZ_CP016431.1|WP_033464715.1|1143500_1144874_+|amidase
MNYHPSTHTPLTFHDRTQAFLDGGDSPRDYLERCLDTIARREPVVQGWVVLNEAGAREAADASARRYREGRPLSAIDGMPVGIKDLIETRDMPTQMGSPAYTGNFPKRDSAVVRALREAGAIVLGKTVTTALGFLDPGPTTNAFDPERTPGGSSSGSGAVVGANMVPVAVGSQLVGSMLRPASFNANWVLKPTYGGMNRGERQGFSQSHVGIHAGSAQDMWTTSIEIVRRVGGDPGHPGLYGEAAPPAGRKPARLAVIETEGWERLDAASRAAFEAALERIAGQGVRIVRRADCSLVDGLERAIAQAGALSMRLISWEHHWSLKNMAEQHPGTLGPSLVRQLELGQAMTLERYRHDILEREAARQRLAALATQCDALLSLASSGPAPRIADLRGTPYPTGDYSFSCVSSLLGAPAISVPALGVDGMPVGLQVIGQPHRDEQVTAIGRWLHELLAAPR
>NZ_CP016431.1|WP_033447495.1|1144911_1145613_-|riboflavin-synthase
MFTGIVQGTATIAGIADRQGLRTFTIDFPAGFCVDLAIGASVSVDGVCLTVTRIVSADTATFDVMLQSLDITTLGGYAVGARVNVERAARDGAEIGGHPLSGHIDFAAAVERVRNMDNNRVLRIGIPPAFRKYVFAKGYIAVNGASLTVSEVDREEGWFEVWLIPETRRMTVFEEKQAGDALNIEIERSTQVVVDTVREAVQESLGRLQPVLEAILKEKGLSLEDFVRPPALK
>NZ_CP016431.1|WP_033447497.1|1145922_1146912_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MKSIQSRLLATWAVCAAAGMLAGPAVASGAAYPSKPVTMIVSFPPGGSSDFFTRLVANNLSKMWGQPVVVENRPGAGGNIGAQAGAHAPADGYTLYMSSINTHAINPGLYQNPGYDHIKDFAPISEIATVMNVLVVNPSVPAKSVGELLAYFKADPSKAFYASPGAGTSPHLSSELFKRMTDTPITHVPYKGSNAALTDVMAGMVPMAIDNLPAALAHIKAGKLRALAVTSPKRSPDLPDVPTMDEAGVKGYDVTTWWALFAPAGTPQPIIAKINKDVNALLALPDVKQSIARQGAEPAPSTPGELAQLVEKETARWGKVIKDAKVTID
>NZ_CP016431.1|WP_003809010.1|1147010_1147472_+|Lrp/AsnC-family-transcriptional-regulator
MDATDRKIIAILQENAETPIQSIADQVSLSTTPCWRRVQKLKESGVIRRQVALCDPVALNVGVTVFISVKTNQHSQAWLDRFADHVTDIPEVVEFYRMSGDIDYLIRVVVPDISTYDTVYKKLIRIADLHDVSSSFAMEQLKYTTALPVDYAS

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Crispr_ID: NZ_CP016431_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016431_3

1328812-1328898

Orphan

Consensus_repeat	Method
TCGGTGCCTGTCCCCGCGGGGACAGGCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016431_3

>merge|NZ_CP016431|3|1328812-1328898|CRISPRCasFinder
TCGGTGCCTGTCCCCGCGGGGACAGGCACCCGGGGAAGTGGCAGGCGTGACGGTGGTTCGGTGCCTGTCCCCACGGGGACAGGCACC

>NZ_CP016431|3|3|1328812-1328898|CRISPRCasFinder
TCGGTGCCTGTCCCCGCGGGGACAGGCACC	CGGGGAAGTGGCAGGCGTGACGGTGGT
TCGGTGCCTGTCCCCACGGGGACAGGCACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016431.1\|WP_080699832.1\|1323385_1324852_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341030
NZ_CP016431.1\|WP_033447624.1\|1327359_1327665_+\|DUF4148-domain-containing-protein	unknown	unknown	gnl\|CDD\|379321
NZ_CP016431.1\|WP_033447630.1\|1328157_1328748_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP016431.1\|WP_033447622.1\|1325883_1326891_-\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|273075
NZ_CP016431.1\|WP_033465028.1\|1329653_1330547_-\|isocitrate-lyase/PEP-mutase-family-protein	unknown	unknown	gnl\|CDD\|119340
NZ_CP016431.1\|WP_033465021.1\|1337769_1339155_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273816
NZ_CP016431.1\|WP_068925364.1\|1317851_1321292_+\|DUF748-domain-containing-protein	unknown	unknown	gnl\|CDD\|377502
NZ_CP016431.1\|WP_003809348.1\|1322870_1323374_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239311
NZ_CP016431.1\|WP_033465019.1\|1339151_1340528_+\|MmgE/PrpD-family-protein	unknown	unknown	gnl\|CDD\|377179
NZ_CP016431.1\|WP_033447620.1\|1325011_1325887_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016431.1\|WP_068925368.1\|1333456_1334830_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238627
NZ_CP016431.1\|WP_068925369.1\|1335592_1336594_+\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|223597
NZ_CP016431.1\|WP_080704184.1\|1321288_1322194_+\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223489
NZ_CP016431.1\|WP_050458152.1\|1336731_1337751_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|270296
NZ_CP016431.1\|WP_033465023.1\|1334862_1335582_+\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238497
NZ_CP016431.1\|WP_015064338.1\|1322202_1322634_-\|lipoprotein	unknown	unknown	unknown
NZ_CP016431.1\|WP_068925366.1\|1330747_1333432_+\|aconitate-hydratase-AcnA	unknown	unknown	gnl\|CDD\|236445
NZ_CP016431.1\|WP_033447627.1\|1327728_1328034_+\|DUF4148-domain-containing-protein	unknown	unknown	gnl\|CDD\|379321
NZ_CP016431.1\|WP_080699852.1\|1340596_1341592_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP016431.1\|WP_033465016.1\|1343007_1343706_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715

Protein	Function_ID	Function_description	E-value
NZ_CP016431.1\|WP_080699832.1\|1323385_1324852_+\|MFS-transporter	gnl\|CDD\|341030	cd17477, MFS_YcaD_like, YcaD and similar transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.87185e-93
NZ_CP016431.1\|WP_033447624.1\|1327359_1327665_+\|DUF4148-domain-containing-protein	gnl\|CDD\|379321	pfam13663, DUF4148, Domain of unknown function (DUF4148).	0.000248775
NZ_CP016431.1\|WP_033447630.1\|1328157_1328748_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.59284e-12
NZ_CP016431.1\|WP_033447622.1\|1325883_1326891_-\|biotin-synthase-BioB	gnl\|CDD\|273075	TIGR00433, biotin_synthase, biotin synthase. Catalyzes the last step of the biotin biosynthesis pathway. All members of the seed alignment are in the immediate gene neighborhood of a bioA gene. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	1.16834e-174
NZ_CP016431.1\|WP_033465028.1\|1329653_1330547_-\|isocitrate-lyase/PEP-mutase-family-protein	gnl\|CDD\|119340	cd00377, ICL_PEPM, Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate lyase (ICL), and 2-methylisocitrate lyase (MICL). Isocitrate lyase (ICL) catalyzes the conversion of isocitrate to succinate and glyoxylate, the first committed step in the glyoxylate pathway. This carbon-conserving pathway is present in most prokaryotes, lower eukaryotes and plants, but has not been observed in vertebrates. PEP mutase (PEPM) turns phosphoenolpyruvate (PEP) into phosphonopyruvate (P-pyr), an important intermediate in the formation of organophosphonates, which function as antibiotics or play a role in pathogenesis or signaling. P-pyr can be hydrolyzed by phosphonopyruvate hydrolase (PPH) to from pyruvate and phosphate. Oxaloacetate acetylhydrolase (OAH) catalyzes the hydrolytic cleavage of oxaloacetate to form acetate and oxalate, an important pathway to produce oxalate in filamentous fungi. 2-methylisocitrate lyase (MICL) cleaves 2-methylisocitrate to pyruvate and succinate, part of the methylcitrate cycle for the alpha-oxidation of propionate.	1.99842e-95
NZ_CP016431.1\|WP_033465021.1\|1337769_1339155_+\|FAD-binding-protein	gnl\|CDD\|273816	TIGR01813, Fumarate_reductase_flavoprotein_subunit, flavocytochrome c. This model describes a family of redox proteins related to the succinate dehydrogenases and fumarate reductases of E. coli, mitochondria, and other well-characterized systems. A member of this family from Shewanella frigidimarina NCIMB400 is characterized as a water-soluble periplasmic protein with four heme groups, a non-covalently bound FAD, and essentially unidirectional fumarate reductase activity. At least seven distinct members of this family are found in Shewanella oneidensis, a species able to use a wide variety of pathways for respiraton. [Energy metabolism, Electron transport].	1.39056e-56
NZ_CP016431.1\|WP_068925364.1\|1317851_1321292_+\|DUF748-domain-containing-protein	gnl\|CDD\|377502	pfam05359, DUF748, Domain of Unknown Function (DUF748).	1.73228e-36
NZ_CP016431.1\|WP_003809348.1\|1322870_1323374_+\|peroxiredoxin	gnl\|CDD\|239311	cd03013, PRX5_like, Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 suggests that it may have an important antioxidant role in organelles that are major sources of reactive oxygen species (ROS), as well as a role in the control of signal transduction. PRX5 has been shown to reduce hydrogen peroxide, alkyl hydroperoxides and peroxynitrite. As with all other PRXs, the N-terminal peroxidatic cysteine of PRX5 is oxidized into a sulfenic acid intermediate upon reaction with peroxides. Human PRX5 is able to resolve this intermediate by forming an intramolecular disulfide bond with its C-terminal cysteine (the resolving cysteine), which can then be reduced by TRX, just like an atypical 2-cys PRX. This resolving cysteine, however, is not conserved in other members of the subfamily. In such cases, it is assumed that the oxidized cysteine is directly resolved by an external small-molecule or protein reductant, typical of a 1-cys PRX. In the case of the H. influenza PRX5 hybrid, the resolving glutaredoxin domain is on the same protein chain as PRX. PRX5 homodimers show an A-type interface, similar to atypical 2-cys PRXs.	1.07728e-77
NZ_CP016431.1\|WP_033465019.1\|1339151_1340528_+\|MmgE/PrpD-family-protein	gnl\|CDD\|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	4.33833e-94
NZ_CP016431.1\|WP_068925368.1\|1333456_1334830_+\|amidohydrolase-family-protein	gnl\|CDD\|238627	cd01302, Cyclic_amidohydrolases, Cyclic amidohydrolases, including hydantoinase, dihydropyrimidinase, allantoinase, and dihydroorotase, are involved in the metabolism of pyrimidines and purines, sharing the property of hydrolyzing the cyclic amide bond of each substrate to the corresponding N-carbamyl amino acids. Allantoinases catalyze the degradation of purines, while dihydropyrimidinases and hydantoinases, a microbial counterpart of dihydropyrimidinase, are involved in pyrimidine degradation. Dihydroorotase participates in the de novo synthesis of pyrimidines.	5.85914e-141
NZ_CP016431.1\|WP_068925369.1\|1335592_1336594_+\|GTP-binding-protein	gnl\|CDD\|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	1.17813e-65
NZ_CP016431.1\|WP_080704184.1\|1321288_1322194_+\|dienelactone-hydrolase-family-protein	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	3.68512e-65
NZ_CP016431.1\|WP_050458152.1\|1336731_1337751_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	5.31641e-115
NZ_CP016431.1\|WP_033465023.1\|1334862_1335582_+\|isochorismatase-family-protein	gnl\|CDD\|238497	cd01015, CSHase, N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.	9.01286e-40
NZ_CP016431.1\|WP_068925366.1\|1330747_1333432_+\|aconitate-hydratase-AcnA	gnl\|CDD\|236445	PRK09277, PRK09277, aconitate hydratase AcnA.	0
NZ_CP016431.1\|WP_033447627.1\|1327728_1328034_+\|DUF4148-domain-containing-protein	gnl\|CDD\|379321	pfam13663, DUF4148, Domain of unknown function (DUF4148).	0.000241234
NZ_CP016431.1\|WP_080699852.1\|1340596_1341592_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	2.4627e-151
NZ_CP016431.1\|WP_033465016.1\|1343007_1343706_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	2.60657e-41

>NZ_CP016431.1|WP_033447630.1|1328157_1328748_+|TetR/AcrR-family-transcriptional-regulator
MDTPSTNSTRDQLLDYAQKLIRTRGCNGFSYRDLADHVGVKTSSVHYYFPCKDDLLYEAVENYTGSALETLRGISPTLPAKERLDAYIAMVESHSCQADQLCLGGMLAAELNTLPERVRAALQAFFTVEENWLANVLADGAREGTLRYASTPEKAARALFATVQGCLLGARLFQRPPDLREALGALYVQCGESPAH
>NZ_CP016431.1|WP_033447627.1|1327728_1328034_+|DUF4148-domain-containing-protein
MNRIATALILSASVFGVAQAGELDYPPAIESAGTLSHAQVQAELQAARTQGLMAAGEQDYPVTAYAAASAVSREQVRNELAAARAQGLTESGELAYPPVAG
>NZ_CP016431.1|WP_033447624.1|1327359_1327665_+|DUF4148-domain-containing-protein
MNRIATALILSASVFGAAQAGELDYPPAIESASTLSHAQVQDELLAARAAGQMNSAELAYPPVVEQAAAQVSRSQIRQELSAAKAQGLDASGELDYPPVAG
>NZ_CP016431.1|WP_033447622.1|1325883_1326891_-|biotin-synthase-BioB
MHTAYIPVPTPVRPPSAERWPLAAVAELFELPFLDLLHRAQQVHRQHFDANTVQLSSLLSIKTGGCPEDCAYCPQSAHYDTGVDADKLMPLDEVVRAARAAQANGAQRFCMGAAWRSPKPHHLEAVAEMIGAVKALGMETCVTLGMLRDGQAGQLKAAGLDYYNHNLDTAPEFYGKIISTRTYQDRLDTLQQVREAGINVCCGGIVGMGESRRDRAGLVAQLANMEPYPESVPINNLVQVEGTPLAGAETLDPFEFIRTIAVARITMPLAKVRLSAGRETMSDSEQALCFMAGANSIFYGDVLLTTGNPQVEADRRLLQRLGMRAEGLPCAAGQA
>NZ_CP016431.1|WP_033447620.1|1325011_1325887_-|hypothetical-protein
MNQGLLYLAASVACSVTVAVLLKLARRHAIDVRQAIAVNYAVAAALCWLLLRPDAQALRQAMQGAPVLAALAVLLPTVFVAMARSVRHAGIVKSDAAQRLSLFIPLLAAFVLFGESLTARKLAAIALAFAALACLLRRRAPAGAAMQDAPEDRRAAWMWPLAVWAGYGVIDILFKQLARSGTAFSAGLLTTFVAAGLLTLAYLCIRRTRWQARHALAGVALGLANFGNILTYVRAHQSLPDHPALVFGAMNMGVITVGTLVGALAFRERLSALNLAGLALALAAIAAMLPW
>NZ_CP016431.1|WP_080699832.1|1323385_1324852_+|MFS-transporter
MLYAAGHRGPRPVLPQADIRVPMLTTISSFSSLYFATLLMLIGTGLFNTYMGLRLTAQSVNEIWIGALIAGYYLGLVCGARLGHRLIIRVGHIRAFVACAAVATSMILAQALVDHLPLWLLLRLISGIVMVTEFMVIESWLNEQTENHQRGRVFSVYMVVSGLGTVLGQLALTAYATLDDGPLTLVAMCLVLCLVPIAVTARSHPPTPLPAPLDLRFFASRVPLSLTVLFVAGNLSGAFYGLAAVYAAKHGLSTSQSAIFVAAAVTAGLLSQWPMGWLSDRINRAGLIRFNAAVLVLLPVLMWGWIVLPYWAMVALSCVFGVLQFTLYPLGAAFANDHVEPERRVGLSAILLMTYGVGACLGPLIAGVMMSLGGPGMYYVFISACAVILVWQVRPARVTGAHQVDEAPVHFVPMPDTLQSSPAAVALDPRVDPDVDITMEMADPGPDVVEPPAPAGPPAPSADSESTSAPQAGEQVAPDDAAARRTGT
>NZ_CP016431.1|WP_003809348.1|1322870_1323374_+|peroxiredoxin
MTIKVGDRVPDGTLTEFIETETAGCTLGPNAFQVADLVKGKKIALFAVPGAFTPTCSAKHLPGYVEQAAALRAKGIDEIWCVAVNDAFVMGAWGREQQAGGKVRMLADGSALWTTALGLELDLVQRGMGVRSQRYSALIDDGVVKQLNIEAPGKFEVSDAATMLAQA
>NZ_CP016431.1|WP_015064338.1|1322202_1322634_-|lipoprotein
MTRHFLAALLLAAASGAASAQAGADPAGQAIFDQIVLTSGAANGAARTCGASPPDLAQHAETWRLNLRRYADEYHYAFDSFDERYARGQQEGAEMMADMRASGVDGCTGALASFQRERTMTYDEMKQAIAEATDGLPEDQPAD
>NZ_CP016431.1|WP_080704184.1|1321288_1322194_+|dienelactone-hydrolase-family-protein
MTHRRFPMTDADPHFDSLLPPLTLTRRGFVVTSLAAGFSLAAGAAAAQSAIHTDAAGLTAGKVDIPTPDGKMPAYRAAPAGKKDLPTLLVVSEIFGVHEYIQDVCRRLARLGYQAVAPELFARYGDPTGYTDIGRLRAEVVDKAGDRQVLADLDAAAAWAAANGGNPSRLGILGFCWGGRIVWLYAAHNPGLKAGAAWYGQLAGQASELKPRSVLESIGDLKAPVLGAYGGKDAGIPLSDVDRMRLALAKGPQAARDSRIDVYPEAPHAFHADYRPSYRKAEAEQAWQRMLDWFGQHGLAA
>NZ_CP016431.1|WP_068925364.1|1317851_1321292_+|DUF748-domain-containing-protein
MPVRMPGVRLTRRTVKVLLATVLVVLLLAGLAAWQVPRIVRGALTQDVSAMLGRDVSVGKIRFNPFTLTLRAHDLALAQPEGAAPLLQVAELDVSASWMSLFWFAPVVDSLVVRQPRIALVREDVTRFNFSDIQQKVADMAAQAPPEPEPRPGLPRFSLNNMVLEGGEITLDDKVSGRQQRIDEIALGVPFISTFGYATDIDVQPRVHMRINGSPFDLTGVARPFDTVPSSTLDVSFAGLELEKWADAWPLPLPVKLERALLDSNLQVLFEQPRDAAPRIKVVGELGLRQLDVRESSGDVLAQWGALAVRRIAFEPMQRSLYIGEVELWSPQIQTRRYADQRLNWLDIAQKLQKLGAGDAPARPAAAPAPTPAPATPAPAPAPAPAAEAAAAPQASAASAPPDAWHVAVDAINVRDAELHLRDAVTKLDYVMNGVGATVEGLELPQPPDRPIGLWLTMDSTIDGSWLRAKGPLTLEPLNLDVKVELDRLALARLAPAVRASAPILVEDGRLGAQARVRLAQREGGTQVVAEGVALRLSDLSLRDESVKPAVPVSVKQFEARFDRLAPDAQPSPFTLKVDGVQGEGALAMQGALTAQPLALKSSVDLARLDLAPFAPYIASSLNATVRAINLSARGDAEFAAAAGAAPMKAAWRGAVDVNDLDLADRVNRDDFMQWKRLGLAGMQVSVNGDAFAANLGDITLEDFYGRVLLNAEGRLNVMDLVAEPGQAGGSITQDTQTRARAAAPAKPGPMPDIAIGSVTLKGGKMTFTDRFVKPNYTAELSRIEGSVSAVSSRQPKPAKVNVAGRVYTSAPFSISGTVQPFAQFLSLDLKASAKGVDLPRFTTYSAKYVGYPIKRGKLSLDVQYQIKDRALQASNRVVLNQLTFGDKTDSPDAVKLPVLLAVALLKDSRGNIDINLPISGSLDDPQFSVGGIIVRVLVNLVVKAVTSPFTLLASAFGGGEELSYIEFDPGSAALTPDAESRIETLAKALNDRPGLKLDVAGRADPASDEEGLRQAWVERQIRLAKARDTAGRGKKPAPDGVEVAPAEREKYLEEVYDDTKIEGKPRNFIGMAKSIPAEQMEALLRGAAPVGADDLRKLADARAQAVYEKLQAAGPADRIFVVAPQLDADGIKDDGKPTRVDFSLK
>NZ_CP016431.1|WP_033465028.1|1329653_1330547_-|isocitrate-lyase/PEP-mutase-family-protein
MSSAAKKFRDLLNSAEFIVSPGVYDGYSLRLVQAAGFKTACTSGAALSNALLGIADIGVMGLMENVNHCRMLARSVDIPLTADADTGYGNPVNVFHTVQMFEEAGVAGVNLEDQVSPKRCGHMPGKDVIPLEEMVKKIEAACLARRDDNFVIIARTDALAVEGIEGAARRAQAYAAAGADVIFPDAVRTAEDIGRIVEAAGVPVSVNMGFGVRQRPTTPLIPLPELKRLGVKRISLPRMLPAAAIHGMRSALEEMKNVIATGTPAHRPDLLVGIEDIMELMDYETMRALEKKLTTLD
>NZ_CP016431.1|WP_068925366.1|1330747_1333432_+|aconitate-hydratase-AcnA
MLSRMTDRGYMNASFLHQGTPIHYADVAAAAARCGVELASLPYVIRILLENLLRHRGRGRPVQEAEIEAVAHWQAHISEQISLHVERVILPDSSGLPVLQDLAALRDAVRAGGGDPARVDTRVPVDLIVDHSLQVDAWSREDAVRRNLDAEFARNEERYRFLKWAQQAFDGLRVYAPGTGIIHQVNLEKLASVVSTGEHGGQQWACPDFVIGGDSHTPMVNGLGVLGWGVGGIDAESALLGRAYTFPIPEVVGVELKGAFRSPVTTTDAALLVTQRLRAEGVTGCMVEFFGEALPGLSVADRATIANMAPEYGATCGFFPVDGQTLDYLRLTGRPAEHIELVRAYCQANGLWRADPTASAVRYARVVRIDLTQAEPCMSGPRRPQDRLPIGQLAEDFRQRLPRPAAEGGFGLDAAALARAPGSAGLRHGSIVVAALTSCTNTSNPSVMLTAALVARAARQRGIAPPAWVKRSLAPGSRTVTDYLAATGLLEDLEALGFGVIGYGCTTCGGKSGPLAPEVAQDIADNQWVVCTVLSGNRNFEGRIHKLARANYIGSPPLVVAYALAGRIDIDFSREPIATDAQGQPVWLHELWPSEAQLDGIMARALSPQGFRKVWGLEPEGASQWRALAEVSGQHWHWDDSSYLVEPPFFKAPAQQFGQRLGGARVLGLYGDSLTTDHISPSGEIPAEAPAGQYLLSLGVAQRDFNTYVARRSNFEVMTRATFGNIRIRNLLVPGTEGGYTRHFPSGELLSIYDASRRYMAAGTPTIVLAGEEYGTGSSRDWAAKGTALLGVRAVLAKSYERIHRANLVGMGVIPFQFERGQGWRELGLDGSETFEFFDVLDGIRQGRPVRVAASRDDGMRVEFSVMPQALTESERELLLQGGIPASVLADYLQ
>NZ_CP016431.1|WP_068925368.1|1333456_1334830_+|amidohydrolase-family-protein
MARPLDTLLANTLVFLEGQGLVSGSIGIVDGRIAVIGSHGQDMPAARETIDCQGLWTLPGVIDPHVHFGFGSPETDFETESRNAALGGTTSVISFHRSADIRESFDAVRERAESQSCIDFGFHFGITSRLHVDTLDEISRRFGVSSYKLYMMYKGAAGLSKGFTDIDDGLLWGALNATRAIPGAVLGVHCENVEVIPWLRDPLRAAGRDDLAAWNEQSPDFLEAENVHRVCYFAGKTGTPVNIVHLSSREALREVRRHRHEGRAAPIYVETCPHYLFLDDRSPAGTYAKVNPPVRSAADIDAMWEGVCDGAITTIGSDHVPRKRATKDKDIWAASNGFPGTGMILPILLHEGYHRRQVPLETLMRVASGATARIYGMPGKGRIAVGNDADLVIVDPDLEKTVDPGELESHADYSPYEGMRLKGWPVRTLVRGRTVARDGRIVDEARQTPGGRYLRRL
>NZ_CP016431.1|WP_033465023.1|1334862_1335582_+|isochorismatase-family-protein
MSETKRIWDAFLTERDKEVYKAAGYGKRGGFGKRPALFIIDVQYNFCGDKPEDILEGLKQYRTHCGAEAWDAVKHIVPLLELAREKNLPVFYTESGRRNDLLDSGVQVGKNHRGGEKTVLANTHATRTVEELAPLPQDIRIVKQKPSCFFGTIFMSHLNFFDVDTLILVGCTTSGCLRATTVDAYSYNFKVIIPEEASFDRFQSSHAMSLFDLNCKYADVIPTAEVAEYLKALPAREAG
>NZ_CP016431.1|WP_068925369.1|1335592_1336594_+|GTP-binding-protein
MSTIPITLLTGFLGSGKTSLLRRLIHQPGFARCAVIINEFGEVGLDQALVADQSDDRDIQLLDSGCLCCLASSAIQDTLASLYYRRLRGEIPWFDRVLIETSGLAEPGPIINAVYGDGALARQFRFAGIVTTFDAGFGQGDVQAYAEAKTQLLMADTVVLTKLDLHPEARHLAAWLGELNPTARIYDNSLPDETLARLLLDPAADRPVPAAQGHVPAGAPQASALRHLLAYGIHSVTVDVPDAIGWPAWAAFVHEVQRTFADRLLRLKGVLAFAGQGRMVVHAVHHVFSAPELAGAVPPGLVGKLVFIVRDMEREEVAHAARHLTGAPPADDA
>NZ_CP016431.1|WP_050458152.1|1336731_1337751_+|LacI-family-transcriptional-regulator
MNFYNFGFLPGAARTRRRVTATVLALAAWAALPAQQAAAQPQWPQRPVTLIVPFAPGGPTDITARVLGEALGKEWKQTVVIENRAGAGGTVGAGFAAKAAPDGYTLLLGVTGSHGIAGSLYPSLTYDPKGDFEAISKVVFYPNAIIANPDVPANNLQELIALAKKDPKYQVYGTDGNGTASHLTMELLRERGGFPMQAVQYKGASPLINDIVAGFVPVGITGFPSAEPQVKAGKLKLIALTTDKDYSGNGYPTIAGQGFPGFAAAPWSGVFAPKGTPAPVVQKIAADIKTVMASPDVVEKMEKLGLTPSAVTLADFETELDRERASWATAVKISGAKVQ
>NZ_CP016431.1|WP_033465021.1|1337769_1339155_+|FAD-binding-protein
MQFDMEFDVVIVGAGGCGLTAAVAIHDAYPQASIAVLDKAERACGNTVLSSGSIPAAGTRFQQAAGVHDTPRMFQEDLLTIAGEHEAMDLTRALTETSARLVEWLVDSAHVRLTLVETYKHIGHRVHRLHSPPSRRGADLVDDLLRECERRDIPVAWSNAVTGLIASEGRPRGVECATPDGAVTRVGARHVVLASNGYAANKTLLARFVPEVAAAPYGGGTGSEGEAILWGESLGAGLANMKAYQGHASLADPHGSLVTWTVIEKGGIIVDRSGRRFGDESIGYSAFAALELARTGPFWVIADTRVRDVTAAGQEEYAELVAHGGVLEGGLEELCARTGIDAAGLAATLRAARQCAADGGADAHGRAQWGLGPLGERLTATRIGPAIFHTQGGLRVDIDGRVLTDQAGVIDGLWAGGGAACGISGNRGSLGYMSGNGLLSALGLGLRIGQAIASRLGEEQA
>NZ_CP016431.1|WP_033465019.1|1339151_1340528_+|MmgE/PrpD-family-protein
MTHDFSGSLMAGGTPTRALADWCAALRDGRPSEAVLRESARHVLDTLAACAAGMRQPLVRAAIELERGINAQPGPVALFGGPERWTVLESAGLMAVACHALEMDDGNREGSIHPATTVVPAVLALGWRQGADYLEFLCAVVAGFEVAVSIAEALHPHASQRGFQTTPVAGVVGAAAACATLLGLDSAGIESAMGLAASASGGLFAYLAGGGNVKKFHPGHAAREGLRAALMARQGAAQGPRGVIEGHAGLLQAFGGLAQWDGSRARERAAPAIVRSYLKPYPCCRHIHPAVDAVLALKAGAAWQAADVAAIEVETYGAAMPHARLPWDTLEVAQLSFPWVMALACADGAVTLAGFSEAARARPDLNALAARVSVTQTQECDSLYPASGPARVTLRLRSGESLSEWVADPLGSADRPLADEALDRKAEEAFGLVFPAAKVQALIGQLRRLEPWPLAELY
>NZ_CP016431.1|WP_080699852.1|1340596_1341592_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MSRKFLSALRNAGMCGVMMLGGLSAAPAAAADAWPGQPIRMVVPFAPGGAVDTLGRLVARQLTEVLGQSVVVENKPGAGGNIGSNIVAKAAPDGYTLLFGAAGNITINPSLFDNMPYDVEKDLAPAALAGQSMNVLVVPAALPVNSVAELIDYARKHPDKLNYGSSGNGGTTHLAGELFNAMAGTRITHVPYQGSGPAMIDLLAGRVQLMFDNLPSAMPHIQRGDLKALGVTGAMRSPQLPDVPTIAETGLAGFEATTWFGVFAPAGTPQAVLERLNGAVNKVMQSAPVEQKLQSMAAYFQPTSRAQFQTLIHDDTAKWARVIKAAGIKLN
>NZ_CP016431.1|WP_033465016.1|1343007_1343706_-|GntR-family-transcriptional-regulator
MKEKSITAIDKNGIDAPLTDVVYQRMLDGIYAGGLPPGGVINEVELAREFGVSRGPVREAVRRLQGIQIVTREPYMKARVVAMSAESALELFQMRMGLEGVACFLATQRMSDADIAQLQRDMDAHYQSWAARREGAPNGEERHFDLHERIVRASGNKRIIAALCEDLYHLLRIYRRHSGSALERKDDAYDEHWQIVRAIASRDARLAESLMRSHIERAANHVASQLSEPAIQ

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Crispr_ID: NZ_CP016431_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016431_4

2262993-2263155

Orphan

Consensus_repeat	Method
GTCGTGCCGCGGCCCAAGGTTGAAACGGCGCAGCCGCTTCCGCCCCGGCCGGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016431_4

>merge|NZ_CP016431|4|2262993-2263155|CRISPRCasFinder
GTCGTGCCGCGGCCCAAGGTTGAAACGGCGCAGCCGCTTCCGCCCCGGCCGGTGGCGGCCCAGACGGTGCCGGTGACGTCTCCCAAGGTGGACGTCGCCAAGGTGGACGTCGTGCCGCGGCCGAAGGTTGAAACGGCGCAGCCGCTTCCGCCCCGGCCGGTGG

>NZ_CP016431|4|4|2262993-2263155|CRISPRCasFinder
GTCGTGCCGCGGCCCAAGGTTGAAACGGCGCAGCCGCTTCCGCCCCGGCCGGTGG	CGGCCCAGACGGTGCCGGTGACGTCTCCCAAGGTGGACGTCGCCAAGGTGGAC
GTCGTGCCGCGGCCGAAGGTTGAAACGGCGCAGCCGCTTCCGCCCCGGCCGGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016431.1\|WP_068925963.1\|2269543_2271298_+\|filamentous-hemagglutinin-transporter-protein-FhaC	unknown	unknown	gnl\|CDD\|377148
NZ_CP016431.1\|WP_068925947.1\|2241318_2242368_+\|TRAP-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270320
NZ_CP016431.1\|WP_033462271.1\|2274328_2275627_-\|TRAP-transporter-large-permease-subunit	unknown	unknown	gnl\|CDD\|129868
NZ_CP016431.1\|WP_033467892.1\|2246585_2247380_+\|putative-hydro-lyase	unknown	unknown	gnl\|CDD\|180100
NZ_CP016431.1\|WP_086092757.1\|2244399_2245119_+\|DUF2848-domain-containing-protein	unknown	unknown	gnl\|CDD\|371339
NZ_CP016431.1\|WP_068927766.1\|2273124_2274099_-\|TRAP-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270320
NZ_CP016431.1\|WP_068925957.1\|2248443_2252154_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|182169
NZ_CP016431.1\|WP_033462270.1\|2272617_2273118_-\|TRAP-transporter-small-permease	unknown	unknown	gnl\|CDD\|377284
NZ_CP016431.1\|WP_068925965.1\|2271323_2272625_-\|TRAP-transporter-large-permease-subunit	unknown	unknown	gnl\|CDD\|129868
NZ_CP016431.1\|WP_033462272.1\|2275619_2276111_-\|TRAP-transporter-small-permease	unknown	unknown	gnl\|CDD\|377284
NZ_CP016431.1\|WP_068925959.1\|2252162_2252792_-\|virulence-factors-two-component-system-response-regulator-BvgA	unknown	unknown	gnl\|CDD\|225107
NZ_CP016431.1\|WP_068925955.1\|2247514_2248390_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|376350
NZ_CP016431.1\|WP_068925949.1\|2243093_2244377_+\|TRAP-transporter-large-permease	unknown	unknown	gnl\|CDD\|224509
NZ_CP016431.1\|WP_068925968.1\|2276124_2277090_-\|TRAP-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270320
NZ_CP016431.1\|WP_033462263.1\|2268420_2269551_+\|fimbrial-protein	unknown	unknown	gnl\|CDD\|226069
NZ_CP016431.1\|WP_068925953.1\|2245179_2246529_+\|amidase	unknown	unknown	gnl\|CDD\|235921
NZ_CP016431.1\|WP_033462260.1\|2264163_2264769_+\|fimbrial-protein	unknown	unknown	gnl\|CDD\|339870
NZ_CP016431.1\|WP_068927765.1\|2242476_2243097_+\|TRAP-transporter-small-permease	unknown	unknown	gnl\|CDD\|377284
NZ_CP016431.1\|WP_033467907.1\|2240066_2240975_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP016431.1\|WP_141218012.1\|2265042_2265756_+\|molecular-chaperone-FimB	unknown	unknown	gnl\|CDD\|225663

Protein	Function_ID	Function_description	E-value
NZ_CP016431.1\|WP_068925963.1\|2269543_2271298_+\|filamentous-hemagglutinin-transporter-protein-FhaC	gnl\|CDD\|377148	pfam03865, ShlB, Haemolysin secretion/activation protein ShlB/FhaC/HecB. This family represents a group of sequences that are related to ShlB from Serratia marcescens. ShlB is an outer membrane protein pore involved in the Type Vb or Two-partner secretion system where it is functions to secrete and activate the haemolysin ShlA. The activation of ShlA occurs during secretion when ShlB imposes a conformational change in the inactive haemolysin to form the active protein.	2.59195e-91
NZ_CP016431.1\|WP_068925947.1\|2241318_2242368_+\|TRAP-transporter-substrate-binding-protein	gnl\|CDD\|270320	cd13602, PBP2_TRAP_BpDctp6_7, Substrate-binding domain of a pyroglutamic acid binding DctP subfamily of the tripartite ATP-independent periplasmic transporters; contains the type 2 periplasmic binding protein fold. DctP6 and DctP7 groups of the TRAP transporters that involved in pyroglutamic acid transport. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.54109e-118
NZ_CP016431.1\|WP_033462271.1\|2274328_2275627_-\|TRAP-transporter-large-permease-subunit	gnl\|CDD\|129868	TIGR00786, TRAP_transporter_permease_protein_SiaT, TRAP transporter, DctM subunit. The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family (TC 2.A.56)- DctM subunit TRAP-T family permeases generally consist of three components, and these systems have so far been found in Gram-negative bacteria, Gram-postive bacteria and archaea. Only one member of the family has been both sequenced and functionally characterized. This system is the DctPQM system of Rhodobacter capsulatus (Forward et al., 1997). DctP is a periplasmic dicarboxylate (malate, fumarate, succinate) binding receptor that is biochemically well-characterized. DctQ is an integral cytoplasmic membrane protein with 4 putative transmembrane a-helical spanners (TMSs). DctM is a second integral cytoplasmic membrane protein with 12 putative TMSs. These proteins have been shown to be both necessary and sufficient for the proton motive force-dependent uptake of dicarboxylates into R. capsulatus. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	4.4406e-99
NZ_CP016431.1\|WP_033467892.1\|2246585_2247380_+\|putative-hydro-lyase	gnl\|CDD\|180100	PRK05463, PRK05463, putative hydro-lyase.	0
NZ_CP016431.1\|WP_086092757.1\|2244399_2245119_+\|DUF2848-domain-containing-protein	gnl\|CDD\|371339	pfam11010, DUF2848, Protein of unknown function (DUF2848). This bacterial family of proteins has no known function.	6.17313e-91
NZ_CP016431.1\|WP_068927766.1\|2273124_2274099_-\|TRAP-transporter-substrate-binding-protein	gnl\|CDD\|270320	cd13602, PBP2_TRAP_BpDctp6_7, Substrate-binding domain of a pyroglutamic acid binding DctP subfamily of the tripartite ATP-independent periplasmic transporters; contains the type 2 periplasmic binding protein fold. DctP6 and DctP7 groups of the TRAP transporters that involved in pyroglutamic acid transport. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.76228e-122
NZ_CP016431.1\|WP_068925957.1\|2248443_2252154_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|182169	PRK09959, PRK09959, acid-sensing system histidine kinase EvgS.	1.57629e-151
NZ_CP016431.1\|WP_033462270.1\|2272617_2273118_-\|TRAP-transporter-small-permease	gnl\|CDD\|377284	pfam04290, DctQ, Tripartite ATP-independent periplasmic transporters, DctQ component. The function of the members of this family is unknown, but DctQ homologs are invariably found in the tripartite ATP-independent periplasmic transporters.	8.32595e-16
NZ_CP016431.1\|WP_068925965.1\|2271323_2272625_-\|TRAP-transporter-large-permease-subunit	gnl\|CDD\|129868	TIGR00786, TRAP_transporter_permease_protein_SiaT, TRAP transporter, DctM subunit. The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family (TC 2.A.56)- DctM subunit TRAP-T family permeases generally consist of three components, and these systems have so far been found in Gram-negative bacteria, Gram-postive bacteria and archaea. Only one member of the family has been both sequenced and functionally characterized. This system is the DctPQM system of Rhodobacter capsulatus (Forward et al., 1997). DctP is a periplasmic dicarboxylate (malate, fumarate, succinate) binding receptor that is biochemically well-characterized. DctQ is an integral cytoplasmic membrane protein with 4 putative transmembrane a-helical spanners (TMSs). DctM is a second integral cytoplasmic membrane protein with 12 putative TMSs. These proteins have been shown to be both necessary and sufficient for the proton motive force-dependent uptake of dicarboxylates into R. capsulatus. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	3.5875e-122
NZ_CP016431.1\|WP_033462272.1\|2275619_2276111_-\|TRAP-transporter-small-permease	gnl\|CDD\|377284	pfam04290, DctQ, Tripartite ATP-independent periplasmic transporters, DctQ component. The function of the members of this family is unknown, but DctQ homologs are invariably found in the tripartite ATP-independent periplasmic transporters.	1.35226e-16
NZ_CP016431.1\|WP_068925959.1\|2252162_2252792_-\|virulence-factors-two-component-system-response-regulator-BvgA	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	7.04344e-63
NZ_CP016431.1\|WP_068925955.1\|2247514_2248390_+\|EAL-domain-containing-protein	gnl\|CDD\|376350	pfam00563, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.	3.05132e-41
NZ_CP016431.1\|WP_068925949.1\|2243093_2244377_+\|TRAP-transporter-large-permease	gnl\|CDD\|224509	COG1593, DctQ, TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism].	1.02288e-87
NZ_CP016431.1\|WP_068925968.1\|2276124_2277090_-\|TRAP-transporter-substrate-binding-protein	gnl\|CDD\|270320	cd13602, PBP2_TRAP_BpDctp6_7, Substrate-binding domain of a pyroglutamic acid binding DctP subfamily of the tripartite ATP-independent periplasmic transporters; contains the type 2 periplasmic binding protein fold. DctP6 and DctP7 groups of the TRAP transporters that involved in pyroglutamic acid transport. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.04581e-122
NZ_CP016431.1\|WP_033462263.1\|2268420_2269551_+\|fimbrial-protein	gnl\|CDD\|226069	COG3539, FimA, P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion].	1.46507e-07
NZ_CP016431.1\|WP_068925953.1\|2245179_2246529_+\|amidase	gnl\|CDD\|235921	PRK07056, PRK07056, amidase; Provisional.	0
NZ_CP016431.1\|WP_033462260.1\|2264163_2264769_+\|fimbrial-protein	gnl\|CDD\|339870	pfam16970, FimA, Type-1 fimbrial protein, A. FimA is a family of Gram-negative fimbrial component A proteins that form part of the pili. There are usually up to 1000 copies of this subunit in one pilus that form a helically wound rod onto which the tip fibrillum (FimF.FimG, FimH) is attached. Pilus subunits are translocated from the cytoplasm to the periplasm via the general secretory pathway SecYEG.	5.44593e-64
NZ_CP016431.1\|WP_068927765.1\|2242476_2243097_+\|TRAP-transporter-small-permease	gnl\|CDD\|377284	pfam04290, DctQ, Tripartite ATP-independent periplasmic transporters, DctQ component. The function of the members of this family is unknown, but DctQ homologs are invariably found in the tripartite ATP-independent periplasmic transporters.	1.9702e-16
NZ_CP016431.1\|WP_033467907.1\|2240066_2240975_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	7.81536e-42
NZ_CP016431.1\|WP_141218012.1\|2265042_2265756_+\|molecular-chaperone-FimB	gnl\|CDD\|225663	COG3121, FimC, P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion].	4.48157e-75

>NZ_CP016431.1|WP_068925959.1|2252162_2252792_-|virulence-factors-two-component-system-response-regulator-BvgA
MYNKVLIIDDHPVLRFAVRVLMEKEGFEVIGETDNGIDGLKIAREKIPNLVVLDIGIPKLDGLEVIARLQSLGLPLRVLVLTGQPPSLFARRCLNSGAAGFVCKRENLHEVINAAKAVMAGYTYFPSTTLSEMRMGDNAKSDSTLISVLSNRELTVLQLLAQGMSNKDIADSMFLSNKTVSTYKTRLLQKLNATSLVELIDLAKRNNLA
>NZ_CP016431.1|WP_068925957.1|2248443_2252154_-|transporter-substrate-binding-domain-containing-protein
MPVLHRLFPRSLICLAQALLAWTLLAWAPAHASQEMTLVGKAALPDVEVALDGDDWRWLARKRVLTLGVYAPDIPPFDVTHDERYEGLTADYMAIIAHNLGVQAKVLRYPTREQAVSALESGQIDLVGTVNGIEGRQQSLRLSVPYAIDQPVLATPIGARRAPPPDLAGLRLAVDVNYLPRETLERIYPQATLRYYPSSEQALAAVAYGQADVFIGDALTTSHLVSQSYFNDVRVVAPAQVVTGGESFGVRADNTRLLRVVNAVLEAVPASERRSLIYRWGLGSSISLDFERPAYSQREQQWMERHPVVKVAVLNLFAPFTLFRTDEQFGGISAAVLQLLQLRTGLEFEIIGVDTVEELMAKLRSGEADMAGALFVNTARESFLSFSRPYVRNGLVIVTRQDPAAPADADHLDGRTVAMVRNSAAIPLLKQRYPQAKVVTADNPTEAMLLVADGQADAVVQTQISASYYVNRYFAGKLRIASALDLPPAEIALATARGQTELMSILNKALYSISNDELASIVSRWRGSDGDPRTWYAYRNEIYLLAGLGLLSALLFLSWIIYLRRQIRQRKRAERALNDQLEFMRVLIDGTPNPIYVRDMEGRMLLCNDAYLDTFGVTADAVLGKTIPEANVVGDPSLAREMHEYLLARMTAEREPRFEDRDFALHGRTRHVYQWTVPYGDSLGELKGVIGGWVDITERTELLRELHDAKESADAANRAKTTFLATMSHEIRTPMNAIIGMLELALLRPADQEPDRKSIQVAYDSARSLLDLIGDILDIAKIEAGKFDLAPTRTTLRTLPEGVVRVFDGLARQKGIRLALKTDITGVDDVLIDPLRMKQVLSNLVGNAIKFTTEGQVTLTLTARAEGDTAHVQFSVSDTGCGISEADQQKLFKPFSQVGGGSEAGPAPGTGLGLSISRRLVELMGGTLVMRSAPGVGTTVSVDLQLTMLEKPAQATPPAPAEQAAPQQPRASLRVLVVDDHKPNLMLLRQQLDYLGQRVIAADSGEAALALWHEHAFEVVITDCNMPGMSGYELARRIRAAEAAPGYARAPCVLFGFTASAQMDEAQRCRAAGMDDCLFKPIGVDTLSQHLSEAAARTQPPLPQAAATATDDAPPTFSAESILALTQNDDALIRQLLEEVIRTNRADVTQLQRLHQQADWPKVSDMAHRLAGGARVVSAKTMIDTALALEKKAQGQAAGPSPEIDGLVQALAAQSAMLEAQLTAWLEERPRPEEHA
>NZ_CP016431.1|WP_068925955.1|2247514_2248390_+|EAL-domain-containing-protein
MIHWTNRARSSFEASLSSCRRAVRARQAPVEGLTGAELRAALKRDEFIPAFQPVVDAGTGNLFGVATAMQWAHRYWGLVPEHRYMAAVMRDNLHIVLAQQLLAQVFDLAAAMRRGNRHVGLFIQPEPICLMSRTYSDDVLRNLDNRGLPAFGLTLAVSPSLLQSPYGQQSLLSLRRLQRAGCNLVFTISTFDAESPLQLDTLEICGIALMPELMYALCQGGRAGEACHAIAQLASARRIPVMATGVADEAAAQVAGLLPCRYLLGDHVAPPMTDQRFLYWYYHREMPPNYP
>NZ_CP016431.1|WP_033467892.1|2246585_2247380_+|putative-hydro-lyase
MTILSLAGAGHQARLDARGGKLTGPTANLAPGHVQANLAILPQAVAGDFLRFCQRNPKPCPLLAVSEPGDPSLPELGLDIDIRTDVPRYRVWRDGKLVDEPLDVRGLWRDDLVAFLIGCSFSFEEAMLENGLPVRHIEQGRNVPMYRTDIATHPAGPFSGPLVVSMRPLKAADAIRAIQVTSRFPSVHGAPVHLGDPALIGIADLGRPDYGDAVDIRAGEIPVFWACGVTPQSVVAAVRPEFCITHAPGHMLVTDLLNSRLAAF
>NZ_CP016431.1|WP_068925953.1|2245179_2246529_+|amidase
MQPTLTQQSLALQEGRDTSTGLTEAALARAADPAGEGARVFTRVYAEQARAEARAADALRAAGVTRSAIDGLPISIKDLFDVAGETTMAGSVARQGEPAAARDAVVVRRLRAAGAVIVGRTNMTEFAYSGLGLNPHYGTPRNPWDRGTGRIPGGSSSGAAVSVTDGMASGAIGSDTGGSVRIPAALCGLAGFKPSAQRVSMQGVLPLSANLDSIGPLAPSVRCCATLDAILAGDDDADTPAPAALRGLRLAVPTTLALDGLDAHVSATFAATLAKLAEAGAHIEEIAVPEFAQLADINSKGGFTAAEAWAWHRGLIERAADRYDPRVVARIRRGAEMSAADYIDLLAARQAWREQVEARIAGFDALVLPTVPVVAPAIADLEASDALFGSTNLLILRNPTLINFLDGSALSLPCHEAGTAPVGLMIAAANGSDRRVLAIGMAIEDLLRG
>NZ_CP016431.1|WP_086092757.1|2244399_2245119_+|DUF2848-domain-containing-protein
MAAARFTARYQMKIAFQVQADGATRTVETEIRNLVVAGWAGRDRAAIEHHIEELAELGVPRPSSVPLYYRIAENQLSQAARVQAVGPDSSGEAETFVFSAGGELYVSLASDHTDRKLEAHSVALSKQVCVKPVASDAWRHADVAEYWDELVLRSYIVENGAEVLYQEGTLASLRTPQDLIAGYTQGQASLPEGTGMTCGTVAAIGGIRASTTFIMELHDPRRQRSLRHRYDVEVLPEIA
>NZ_CP016431.1|WP_068925949.1|2243093_2244377_+|TRAP-transporter-large-permease
MIATALILLLVLIGISIPVGAALGVLGLILDPLYSMLPLTRAIGEVTWSANNEFLLVAIPLFIMLGEVLLRAGFAERMYAAMSLWLSWLPGGLMHANIGASTLFSATSGSSVATAATVGTVAIPQIKKYGYNEPLFLGSLAAGGTLGILIPPSINLVIYGVLTNSSVPKLYLAGIIPGFAMAALFMATVVVACVARPSWGGHRIQASWAERIASLVHLGPPMAIFFLVVGSIYAGLATPTEAAALGVLGALILAAWFRRLTWTMLREAIEGTMRSTAMIMLIVLAASFLNFVMSATGLTDALVQSITGLGLSPGWMLLIVVIFYLVLGCFMETLSMMITTIPIVAPIMIALGYDPIWLGILIIVLVEAALITPPVGLNLFVVQSLRKSGSMTAVINGALPFVLAMFVMLALLAFFPDLALWLPRVFG
>NZ_CP016431.1|WP_068927765.1|2242476_2243097_+|TRAP-transporter-small-permease
MTRSEHFRALGGLLRRAESLSRLAVWVGGALTIASVLLISFDVLARKFFGFTTGGADELSSYAFAISTSWALAFATLQRANVRVDVVYQYLPVRVSAVLDWIALVALGVFMVFMTYYAYEVVQTSWAQKSAANTPLATPLWVPQGLWALGLAWMCVTVALMLVRASAALITGDLDLVKEICGVRSAQEEAEEEAAAGERMVKGASA
>NZ_CP016431.1|WP_068925947.1|2241318_2242368_+|TRAP-transporter-substrate-binding-protein
MKKPLIFAAAFAVAALTGAAHAQDLPKTKVKVVGGLSNLTAYNDYEKPFWTKTVPELSKGQVTADIKGFNEMGLKGPEILRLMSQGVIEFGTATLAYFASDNPINEAIDLAGLAPDAKTARQVTDAFEPVYAKLYGEGANVKLLGISTYPAQVLFCNAEIKGLADIKGKKVRTSSRTTAEFVEALGGSSVTMAFGEVVPALQNKVVDCAITGSLSGYSAKWYEVSTHLYALPINWNQQIHAVNQKAWDKLDPKVRTFLQDNITNLVDQIWDAAARQTQEGYDCNTGAAACPYPVKGKMVLVQPTDADRALLKKVTEEAVLPKWAARCSAQCVSDFNATIGKTLGLVAKK
>NZ_CP016431.1|WP_033467907.1|2240066_2240975_+|LysR-family-transcriptional-regulator
MIDLKHIETFFWVSTLGSFRAAAEKLNTTQPAISQRIASLEADLGVRLFERDARGVSLTGKGQELLSHAERMLQMRHDLMQAAREQNVMSGTVRIGVAETIVQTWLPALIEHVHAAYPALVLQIEVDTTHVLRGQLMARQIDVAFLMGPILEARMENIPLCAYPLAWVASPLLDLGPEPLTLERIGTLPVITYPSSSEPYRQVRDMLTRAGVAAPRMYGSASLSMVVRMTKDGIGTSVIAPVFLDEELARGELRLLNVQADPLPELAFTATWVQGPDSHAARAIALLAQRAAAEHGGAIGAG
>NZ_CP016431.1|WP_033462260.1|2264163_2264769_+|fimbrial-protein
MNLKFAGIALGLSACALTYQHQALAADGTLVITGAITDTTCKINGTEPPTNVAVQLPTISRTALKDVGSTAGGTVFDVKLTECPQVLNGQQVGLFFEPGGTVDYTSGNLFAYKADGNGAQQVPQTKADNVQFQLANLDGSAIHLGRNKGDQAAQTFLVSQTAGASTYGTTLRYLARYIRSGAGPIVAGNLRSQVGFSVMYP
>NZ_CP016431.1|WP_141218012.1|2265042_2265756_+|molecular-chaperone-FimB
MGAAALGAAVLAGLAPAARASLVITGTRVIYNAGSPETTVKMSNEGQAPALMQAWIDDGNAEAKPDEVQVPFFLTPPLARVDPGKGQTLRIFFNGYPDGKTLPSDRESVFWLNVLEVPPKATPEEGHGVLQLTIRSRLKLFYRPKGLPGNPLTAAADLTFKRKANGVLEVHNPTPYYVNLQKLEVGENGVHGSKTPWMLAPLSSDELRLKGTGAKSVQYWAIDDFGGVTPYQAAIAN
>NZ_CP016431.1|WP_033462263.1|2268420_2269551_+|fimbrial-protein
MSQIFTDRRVAGPARAFSFWGAVLAVWAGLAAQPAMAVDPPVDCGRAIGLHFWSSTSIISDQTPDGTLIGTPVVGRALLSKSCETPDDIKDELSDKHDGEPVDIVLELGSGYQIRPQSYGHPGIVVDLPTGSTEETGIAIYIDFGSSPMQKVGERQWLYPQKGEVLFDALAINGDNSEIRYQAIKVGPLKRPRKLVLSQFPNLFTYKWVFMRGTSQERVLATGTISTDVATSTIDLKTCRYTSQTVSLPTIQRSALTGVGTTLGTTDFHMPFWCYGRPKVSVYLSAAKTQTGVDGVALPATGQAAGMASGVGVQLINGRTQQPVELGLQGKIALPEAQQTDSATFSLPMKAQYYQTSTSTSAGKLSVTYTVTLNYD
>NZ_CP016431.1|WP_068925963.1|2269543_2271298_+|filamentous-hemagglutinin-transporter-protein-FhaC
MTDATTRFAPGRSAVRAIVRASLLFAVAACAQAQLLPGARDLNRIDDRQRKEQLQRDIERALTRPPVELNPQSEAASPAPGPDAASGHTVTVHAVDLDFGVEGRLFDPAPLVQDYLNRPLDNEQLFLLVKALSAALYDRGYATSIVTFVPPGVVDGVLKLKVEWGRIKGWLIDGKPLEGTRDRMMVFSAMPGWQDKVLNVFDIDQAIYNINNGGKTGNITIVPADEYGYSYLDLQLQRRALPRVSLGMDNSGPGTPENGRYKYNASVTANDLLGVNDTLGLYFGNRYYRDAGHDAERNYDLMYSVPLGRTRLDFQAGYSTYRNLLKTRYGQYQSAGNSRSFGLKATRLLYRDTRSQFSVYGGLKLRQNKNYLAGTRLDVSSKHYSDVTVGMQYSTQRGVNAYFGDLSFTRGVGINNGKYAAYDERGPQGNVSRLNGSLAWTRYMALAGQPIQWASQLGFQYSRQQLLNSYQITVGDEYTVRGYNLRTSQSGDSGVYLSNTLTVPVQFSLLGKQASMAPFVGVDVGALKSNHPDARTMHMAGLAAGVRFDLPYARMSFTYSKPVGAQPGDAPRAPVWYINAGLSF
>NZ_CP016431.1|WP_068925965.1|2271323_2272625_-|TRAP-transporter-large-permease-subunit
MNEILIVTLLVVSIFALLGCGVWVGLTLAGTAWIGMEILSSRPAGDAMAVTIWGASSSWTLTALPLFLWMGEILFRTRLSEDLFKGLAPWLNRLPGRLLHTNVIGCAIFAAVSGSSAATCATVGKMTIPELTRRGYPEDKILGTLSGAGTLGLLIPPSIIMIVYGVAADVSIAKLFIAGIFPGLLLGLLFMGYIAWWALRNPGAVPAADAGISFVQKLKQSRHLIPVLLLIGAVLGSIYTGIATATEAAAVGVVGALILSALQGSLTRASFMTSLLGATRLYCMIALILAGAQFLTLAMGYIGLPRALAEWIGGLGLSQFGLVMALMVFFIVLGCFLDGISIVVLTMGVLLPTVQAAGFDLIWFGIFIVFVVEMAQITPPVGFNLFVLAGMSGRELPYIARASLPMFILMILAVLLLYYLPGIATWLPRHMTL
>NZ_CP016431.1|WP_033462270.1|2272617_2273118_-|TRAP-transporter-small-permease
MRRLLDRLYGAAGLLAGLCTIGVLVSVLAAIIARQLGLNIPGTDAYAGYFMAAAGFLALASTFKHGEHIRVTLLLNALSAPGHRRLDIFALFVGTILAAAFAWFSVKLAHDSWLFNDVSTANDATPLWIPQLTMAAGTVLFFVALVDELVRRIRGQGFATSQQIHE
>NZ_CP016431.1|WP_068927766.1|2273124_2274099_-|TRAP-transporter-substrate-binding-protein
MYKKLSLLAGTIVLAFGAGAQAQTKWDLPTAYPASNLHVENLTQFVKDVDSLSGGKLKITLHNNASLYKAPEIKRAVQGNQAQIGEILLTNFANEDPVYELDGLPFLATGYDASFKLYQAQKPFLEKKLASQGMMLLYSVAWPPQGIFANRDIKQVSDMKGLKWRAYSPVTAKIAELVGAQPVTVQQAELAQAMATGVIDSYMSSGSTGFDTKTYEYIKKFYDTEAWLPKNAVLVNKKAFDALDPATQQALKKAGAQAEERGWKLSQEKNSWYKEQLAKNGMAIIAPTAELKSGLSEVGKRMLDDWLKKAGPDGQAMIDAYRKQ
>NZ_CP016431.1|WP_033462271.1|2274328_2275627_-|TRAP-transporter-large-permease-subunit
MGDLAQSLVLIASLLLLLAAGVWVSLALVASGLVALLLFTDAPAGIIFATKSWDASANWALTALPLFIWMGEILYRTRLAEDMFSGLGPWVRRLPGRLVHVNVLGCGIFAAVSGSSAATAATIGRISLPELKARGYDDGLAIGSLAGAGTLGLLIPPSIVMIVYGVAAQVSLIKLFIAGILPGLLLMALFSGYIGVWSLRNPARVPPREPAVPWLAMLARLRLLLPVVALIAGVIGSIYAGIATATEAATIGVIGALAIAAWGKSLNRKSFVDSLMGATRTSCMISFILLGAAYLTSAMSFTGLPANLAEWISSLGLSQYGLIAVLTVFFILMGAFLDGISIVVLTTAVLMPAIQAANIDPIWFGIYLILVVEMAQITPPVGFNLFVIQGITGRNLFELVRMAFPFFLLLVLATALITVFPAIVTALPLAMR
>NZ_CP016431.1|WP_033462272.1|2275619_2276111_-|TRAP-transporter-small-permease
MPILDRIAVASGAVAALFLALIGAIIAAQIASRLLGMQIPAADDFAAWSMAASVFLALPYAMLRGDHIRVTLLLQFLPKAAHRPYELAATALGLALSAWAAWQAAGFVHESFAYDEVAQGMLRVPLWIPQLCMPIGLALLTLMLARRLAMVARGRQPEETPHG
>NZ_CP016431.1|WP_068925968.1|2276124_2277090_-|TRAP-transporter-substrate-binding-protein
MKTPFAVLAAALAFSAGAQAATSWTMTAEQPDANYLTQNARQFADEVKAATAGALEIKVQSNSTLLKRPEVKRGVQQGVVQIGEVLVSALGNEDPLFEIDSVPFLASSFDESEKLWKATRPLLAQRLDKQGIVLVYGSPWPPQGIYTKKPVAALADLKGTRFRAYSASTSHMAALMGAVPTTVQTPEVPQAFSTGVIDAMLTSPATGVDSQAWDYVKYYYDAQAFIPQSFVIANKRAFQRLPAEVRQAVLDAGAKAETRGWQTARAKTRELTDTLARNGMTVEPLPPQLAKELQAIGTTMVSDWSKKADAEGQQLLDAYRK

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Crispr_ID: NZ_CP016431_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016431_5

4258672-4258758

Orphan

Consensus_repeat	Method
GCCAAGGAAGAGGCCGCCAAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016431_5

>merge|NZ_CP016431|5|4258672-4258758|CRISPRCasFinder
GCGCTGGAAGAGGCGCGCAAGAAGCGCGAGCAGGAAGAAAAGGCCCGCCAGGCGGCCGAAGCCGCCAAGGAAAAGGCGCGCCTGGAT

>NZ_CP016431|5|5|4258672-4258758|CRISPRCasFinder
GCGCTGGAAGAGGCGCGCAAGAA	GCGCGAGCAGGAAGAAAAGGCCCGCCAGGCGGCCGAAGCC
GCCAAGGAAAAGGCGCGCCTGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016431.1\|WP_033463928.1\|4261378_4262068_+\|tol-pal-system-protein-YbgF	unknown	unknown	gnl\|CDD\|224643
NZ_CP016431.1\|WP_033450566.1\|4253625_4254312_-\|response-regulator	unknown	unknown	gnl\|CDD\|185376
NZ_CP016431.1\|WP_010931417.1\|4259446_4260763_+\|Tol-Pal-system-protein-TolB	unknown	unknown	gnl\|CDD\|235083
NZ_CP016431.1\|WP_033463934.1\|4263113_4263905_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP016431.1\|WP_033463942.1\|4266675_4267131_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP016431.1\|WP_068927108.1\|4260794_4261292_+\|peptidoglycan-associated-lipoprotein-Pal	unknown	unknown	gnl\|CDD\|274307
NZ_CP016431.1\|WP_094771339.1\|4267226_4268489_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NZ_CP016431.1\|WP_033463919.1\|4254292_4254865_-\|RNA-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|234820
NZ_CP016431.1\|WP_033463939.1\|4265063_4266665_+\|gamma-glutamyltransferase-family-protein	unknown	unknown	gnl\|CDD\|223482
NZ_CP016431.1\|WP_068927105.1\|4257826_4258285_+\|protein-TolR	unknown	unknown	gnl\|CDD\|274306
NZ_CP016431.1\|WP_068927103.1\|4256715_4257144_+\|tol-pal-system-associated-acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|274304
NZ_CP016431.1\|WP_033463947.1\|4268501_4269002_-\|YbaK/EbsC-family-protein	unknown	unknown	gnl\|CDD\|239825
NZ_CP016431.1\|WP_068927101.1\|4254930_4256661_+\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NZ_CP016431.1\|WP_068927098.1\|4249438_4249840_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341115
NZ_CP016431.1\|WP_068927100.1\|4250080_4252057_+\|DUF3120-domain-containing-protein	unknown	unknown	gnl\|CDD\|151953
NZ_CP016431.1\|WP_033463937.1\|4264072_4265059_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP016431.1\|WP_094771338.1\|4252082_4253594_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|273593
NZ_CP016431.1\|WP_068927110.1\|4262067_4263117_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223682
NZ_CP016431.1\|WP_003814641.1\|4257146_4257827_+\|protein-TolQ	unknown	unknown	gnl\|CDD\|131843
NZ_CP016431.1\|WP_068927096.1\|4247754_4248384_-\|FMN-dependent-NADH-azoreductase	unknown	unknown	gnl\|CDD\|234675

Protein	Function_ID	Function_description	E-value
NZ_CP016431.1\|WP_033463928.1\|4261378_4262068_+\|tol-pal-system-protein-YbgF	gnl\|CDD\|224643	COG1729, COG1729, Uncharacterized protein conserved in bacteria [Function unknown].	7.65637e-31
NZ_CP016431.1\|WP_033450566.1\|4253625_4254312_-\|response-regulator	gnl\|CDD\|185376	PRK15479, PRK15479, transcriptional regulator TctD.	2.87323e-80
NZ_CP016431.1\|WP_010931417.1\|4259446_4260763_+\|Tol-Pal-system-protein-TolB	gnl\|CDD\|235083	PRK02889, tolB, Tol-Pal system protein TolB.	0
NZ_CP016431.1\|WP_033463934.1\|4263113_4263905_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.20539e-82
NZ_CP016431.1\|WP_033463942.1\|4266675_4267131_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.85425e-15
NZ_CP016431.1\|WP_068927108.1\|4260794_4261292_+\|peptidoglycan-associated-lipoprotein-Pal	gnl\|CDD\|274307	TIGR02802, Peptidoglycan-associated_lipoprotein, peptidoglycan-associated lipoprotein. Members of this protein are Pal (also called OprL), the Peptidoglycan-Associated Lipoprotein of the Tol-Pal system. The system appears to be involved both in the maintenance of outer membrane integrity and in the import of certain organic molecules as nutrients. Members of this family contain a hydrodrophobic lipoprotein signal sequence, a conserved N-terminal cleavage and modification site, a poorly conserved low-complexity region, together comprising about 65 amino acids, and a well-conserved C-terminal domain. The seed alignment for this model includes only the conserved C-terminal domain.	6.04549e-54
NZ_CP016431.1\|WP_094771339.1\|4267226_4268489_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	5.34833e-40
NZ_CP016431.1\|WP_033463919.1\|4254292_4254865_-\|RNA-pyrophosphohydrolase	gnl\|CDD\|234820	PRK00714, PRK00714, RNA pyrophosphohydrolase; Reviewed.	6.38944e-95
NZ_CP016431.1\|WP_033463939.1\|4265063_4266665_+\|gamma-glutamyltransferase-family-protein	gnl\|CDD\|223482	COG0405, Ggt, Gamma-glutamyltransferase [Amino acid transport and metabolism].	0
NZ_CP016431.1\|WP_068927105.1\|4257826_4258285_+\|protein-TolR	gnl\|CDD\|274306	TIGR02801, Protein_TolR, TolR protein. The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	1.03484e-45
NZ_CP016431.1\|WP_068927103.1\|4256715_4257144_+\|tol-pal-system-associated-acyl-CoA-thioesterase	gnl\|CDD\|274304	TIGR02799, Acyl-CoA_thioesterase_YbgC, tol-pal system-associated acyl-CoA thioesterase. The tol-pal system consists of five critical genes. Inner membrane proteins TolQ and TolR convert protomotive force to energy that is transduced through TolA to an outer membrane complex of TolB and Pal. The system is known to be required to maintain outer membrane integrity. In a system with several homologous parts, ExbB and ExbD transduces energy through TonB to a variety of outer membrane proteins, many of which are siderophore receptors. The tol-pal system therefore may also be involved in transport. This family consists of a protein nearly always found in operons with the genes of the tol-pal system. The significance of this thioesterase to the tol-pal system is unclear, but either of two observations may be relevant. First, Pal, or peptidoglycan-associated lipoprotein, has a conserved N-terminal cleavage and acylation that makes it a lipoprotein. Second, the tol-pal system is implicated not only in the import of certain organics but also in the maintenance of outer membrane integrity (by an unknown mechanism).	6.3702e-67
NZ_CP016431.1\|WP_033463947.1\|4268501_4269002_-\|YbaK/EbsC-family-protein	gnl\|CDD\|239825	cd04333, ProX_deacylase, This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro) deacylase and also the cis-acting prolyl-tRNA synthetase-editing domain (ProRS-INS). While ProX and ProRS-INS hydrolyze misacylated Ala-tRNA(Pro), the E. coli YbaK hydrolyzes misacylated Cys-tRNA(Pro). A few CD members are N-terminal, YbaK-ProX-like domains of an uncharacterized protein with a C-terminal, predicted Fe-S protein domain.	5.9449e-60
NZ_CP016431.1\|WP_068927101.1\|4254930_4256661_+\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NZ_CP016431.1\|WP_068927098.1\|4249438_4249840_-\|hypothetical-protein	gnl\|CDD\|341115	cd17032, T3SC_IA_SycT-like, Class IA type III secretion system chaperone protein, similar to Yersinia enterocolitica SycT. This family includes type III secretion system (T3SS) chaperone proteins similar to Yersinia enterocolitica SycT and similar proteins. In Y. enterocolitica, a food-borne pathogen causing gastroenteritis and mesenteric lymphadenitis, chaperone SycT promotes translocation of effector YopT (Yersinia outer protein T), a cysteine protease that inactivates the small GTPase RhoA of targeted host cells by cleaving its C-terminal, prenylated cysteine, thereby releasing the GTPase into the host cytosol.	1.01893e-32
NZ_CP016431.1\|WP_068927100.1\|4250080_4252057_+\|DUF3120-domain-containing-protein	gnl\|CDD\|151953	pfam11516, DUF3220, Protein of unknown function (DUF3120). This family of proteins with unknown function appears to be restricted to Bordetella.	2.85885e-59
NZ_CP016431.1\|WP_033463937.1\|4264072_4265059_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	2.27674e-102
NZ_CP016431.1\|WP_094771338.1\|4252082_4253594_-\|sensor-histidine-kinase	gnl\|CDD\|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	1.03135e-45
NZ_CP016431.1\|WP_068927110.1\|4262067_4263117_+\|iron-ABC-transporter-permease	gnl\|CDD\|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	7.46256e-71
NZ_CP016431.1\|WP_003814641.1\|4257146_4257827_+\|protein-TolQ	gnl\|CDD\|131843	TIGR02796, Protein_TolQ, TolQ protein. TolQ is one of the essential components of the Tol-Pal system. Together with TolR, it harnesses protonmotive force to energize TolA, which spans the periplasm to reach the complex of TolB and Pal at the outer member. The tol-pal system proves to be important for maintaining outer membrane integrity. Gene pairs similar to the TolQ and TolR gene pair often number several per genome, but this model describes specificially TolQ per se, as found in tol-pal operons. A close homolog, excluded from this model, is ExbB of the ExbB/ExbD/TonB protein complex, which powers transport of siderophores and vitamin B12 across the bacterial outer membrane. The Tol-Pal system is exploited by colicin and filamentous phage DNA to enter the cell. It is also implicated in pathogenesis in several bacterial species [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	5.36586e-98
NZ_CP016431.1\|WP_068927096.1\|4247754_4248384_-\|FMN-dependent-NADH-azoreductase	gnl\|CDD\|234675	PRK00170, PRK00170, azoreductase; Reviewed.	1.21229e-83

>NZ_CP016431.1|WP_068927105.1|4257826_4258285_+|protein-TolR
MPSVRSNGRAGRRMKADINVVPYIDVMLVLLVIFMVTAPLITPGLIELPSVGQASDVPAKPLEVQISEDGKIALRMREPGATPQDIARTELVNQVRSRITAETPVVIAADGKVPYESVVKVMDELRSSGITRLGLLVDQGAGAETQQPARKR
>NZ_CP016431.1|WP_003814641.1|4257146_4257827_+|protein-TolQ
MQVTNDMSLLSLISHASVPVQLIMLLLLGISIMSWTYIFAKRLAIKRAHQQTRRFEDDFWSGGDLAMLQQAVATRRDEQGALARIFDAGMTEFLKARRTSAAGDVNAVLDGPRRAMRAAYQREMDSLESHLNFLASAGSVSPYIGLLGTVWGIMHAFIGLSNMQQATLAAVAPGIAEALIATAIGLFAAIPAVVAYNRFTNDIDRLSIRFDSFVDEFLNILQRQVR
>NZ_CP016431.1|WP_068927103.1|4256715_4257144_+|tol-pal-system-associated-acyl-CoA-thioesterase
MTDPKFSESVLDIRVYYEDTDAGGVVFYANYLKFLERARTEWLRGLGVNQSDLAEREHRLFVVHSLDMSYRKPARLDDLITIRSRITRIGRASIHFAQRAERNGELLAEGNIQICCVDSIRMRPAELPDDIRAKLKFIQIQE
>NZ_CP016431.1|WP_068927101.1|4254930_4256661_+|proline--tRNA-ligase
MRASKYHLNTLKEAPAEAEIASHQLMTRAGMIRKLAGGIYTYMPLGLKVIRKIEGIVREEMNAAGAIELLMPVVQPAELWMESGRWEQYGAELLRIKDRHQRDFVLQPTSEEVITDIARNEIQSYRQLPLNFYHIQTKFRDERRPRFGLMRGREFTMKDAYSFDRDEAGAQRSYDIMYAAYQRIFQRLGLEFRAVAADTGSIGGSRSHEFQVIADTGEDLIVYNPESDYAANIELAEAPALLATRPAPAQDLEAVPTPGAAKCEDVAKLLGLPLARTIKSIVLAVDQPEGPAQVWLLLLRGDHELNEIKAGKLAGLAGFRFATETEITDHFGCKPGYLGPIKTARPVRVVADRTVANMADFVCGANREDYHYQGANWGRDMPEPELVADLRNVVEGDPSPDGKGTLSIQRGIEVGHVFFLGTKYSEALKATFLDDNGKPAVLQMGCYGIGVTRIVGAAIEQNHDARGIIWPRAIAPYEVVICPVGWGKSETVRDTAVALYEALRARGVDVMLDDRDSRPGVMFAEWELIGVPLRVTVGERGLNEGVVELQARREAEAAKVPVDQALAQTLAKLDLL
>NZ_CP016431.1|WP_033463919.1|4254292_4254865_-|RNA-pyrophosphohydrolase
MLDREGYRPNVGIILVNGKNEVFWGKRIREHAWQFPQGGIKYGESPVQAMYRELHEEVGLKPEHVRILGRTRDWLRYNVPDHFVRREWRGHYKGQKQIWFLLRLVGRDSDVCLRATQHPEFDAWRWSQYWVPLDAVIEFKRDVYTQALNELAVILFRRHHETRYLRQRVHGPRSTDNPSSETDDHAHIAG
>NZ_CP016431.1|WP_033450566.1|4253625_4254312_-|response-regulator
MRILLVEDERDMAAWLMRALAQSGFMPDHAPDARTAEGLMAGNEYDAVVMDLRLPDKHGLVLLREMRNRDDRTPVLLLTAQGALQDRVRGLNLGADDFLTKPFALEELEARLTALVRRSRGRQPPRLQCGSLSYDGESRAFTLDGALLFLTPREHAALAALLTRSGYPVDKSQLFGKVFTHESEANPDAIEVVLHRLRKKLTGSDVRIVTVRGLGYMLESTVSESSES
>NZ_CP016431.1|WP_094771338.1|4252082_4253594_-|sensor-histidine-kinase
MGIRALLISLLLPGVVVLLVIDSWNDYRTLAAITNEAYDSALLEPARVLESSLEFAADGTLQVATPLYAQVMLESKAGMRKYYRIEEIDPPWPENLPGMPREPGRALSGMPEMPRPPYWPRSNGQPVFFDAVYRNDPVRAVAVVRDLYYRNQHRQVLVVVAESIGKRVEAEASAQRQEVLRDARMLALVALLVWWGVNWALRPLVRLRNDIRTRRPDDLTPLDATRVPSEVAPLVEAVNHHIARHRRVLDEQSQFLADASHQLRTPLAIMLTQAQYALRERDPVRAQEGLRAIVDQLGRTRRLTEQLLSLAHASQADAPPRQELDLNDVARDVVLQYLPLAHEKQQDLGWVDARGDKAEGASDTAVVPVWGSEVELHEALSNLVHNAINYAPAGAHITVSVVRYADRAEVQVADDGPGIEPLLRARAFARFDRMAGDRHASSSGSGLGLSIARAYARRNDGDIELRDGEPNAQGGVGLCAVFWIPLYDRGAPADEAEAPRRYG
>NZ_CP016431.1|WP_068927100.1|4250080_4252057_+|DUF3120-domain-containing-protein
MLSNNVNPVVGLSYRPLPETPPSGQAAAHPSMRLLEPNNDEFVRSVASPRLRHSSEALREVKHDVRQFQASGDRSLQQLRDLEVALDHWEASQPREFAKRGGMVAELRTAIDAYKQQLREHAPSHANLDVKWLDGLRAGSMALQNDVKVWMQNLEDLRTRRPDEFAARLQQSTDALYSHLEAQWATQHGAPPTASDVAGTPQWREYTAMLRERFAGLGTIRPNLTAEENAVAILNTQTQLLALQRAQEALQASLADGVSHQGDVGLLRTQLLAGMVEGLIALQQSDDDSALWSRPPAADSGGRLSVETGAKTSTDFEAPAGKAEWLRGKGISGEAVLEAFANIEMSVSGSRAGAAGEAEGSLRLYGESTARAEVSGSFEPFALSGNIGREEADGDTETSSNAVLSLNVSAELSSKLGLEAQGSVTLGRLLKLDAEGRAEVGASAEVSGTAAIEKRSDGVGVRLEGQAEAFMGMKAEGTLTANLLHSKYAETHGLTASVTGSANVGLGATAEGKLVASPGQFEMGGEVGTTLGVGGNIGWNSKVDVNASAAYAYELASAAMARFDALRASQLDHDAKTSGNDSQLNRLADNLQSHIDATSHKLDALNSAGIENRIRKVDGAAAGDGAQAAARLAAQMALVGTGADLSHDIKITALNLRA
>NZ_CP016431.1|WP_068927098.1|4249438_4249840_-|hypothetical-protein
MFPLLIRNLRHLLGLPAGADEPVTSLAIDEQWVVHIGCEDDMVTVLLPLGPAPDPLPGTALANSLAQWPPVLLDLSEQGEAILWAREHVGRLTAEQLHALLARLAARAAALMAPDAAPPASPQGTAEVAGRKA
>NZ_CP016431.1|WP_068927096.1|4247754_4248384_-|FMN-dependent-NADH-azoreductase
MKTLVILSSILGDRSNSKQLADHLLARLKQSESGGTVKIRDLAANPVPYFDGATVGALFTPAEARNAEQQRIAALSDELVAELFDADRIVFAVPVYNFNLPAQFKSYIDHIARAGVTFRYTAEGKPEGLVQGKQVLVLIARGGKSEGTPDDTMTPYLKQMLAFLGMTDVTFIAAEGMAMGELAAQEGLALARQRIDALSLDARQGLAAA
>NZ_CP016431.1|WP_010931417.1|4259446_4260763_+|Tol-Pal-system-protein-TolB
MTPAFRRADLTGFLRTYGAALILLLAAMLAWQPAQAQLRVDISGTGATQYPVAIADFAVDDTHGRALAEVIRADLTRTGQFRLINAAGSGLNVDSQVAHDDWRAKGADFLAYGSITRGPDGRYDVRYRLADTVKKGQLDGVAFSGTEQELRRVAHQIADRIYEKITGVRGVFSTRIAYVLKRGSTYELQVADADGQNPQVALRSREPIISPSWSPDGSRLAYVSFESGKPVVYVHTLATSARIPVANFKGNNSAPAWSPDGSQLAVALTRDGLSQIYIVSAGGGSNMRRITRSPGIDTEPNFTPDGRSIIFTSDRSGGPQIYQTGLDGGDARRLTFNGGYNISPRISPDGSTLLYVARRDGAFRIASLNLSSGSETLLTDGRDDQSPSFAPNGMQVLYAAIQNGRSVLAGVSSDGRVRQTLSVLNGEIREPTWGPFTR
>NZ_CP016431.1|WP_068927108.1|4260794_4261292_+|peptidoglycan-associated-lipoprotein-Pal
MKSRIAKSLTIAALAATLAACSSVPLDDKAGQAGGSGQGSATGQILDPFNPQSILAQQRSVYFDFDSYTVSDQYRGLVETHARYLASNNQQRIKIEGNTDERGGAEYNLALGQRRADAVRRMMTLLGVSDNQIETISFGKEKPKATGSSEADFAENRRADIVYQR
>NZ_CP016431.1|WP_033463928.1|4261378_4262068_+|tol-pal-system-protein-YbgF
MRDQALPLRTLVITASLALAAMAAPAHAFADDEARRAILDLRQQVQQQNEQNQRARLQLADQLHAMQQEIAQLRDQLELISRQQPNAQGGQPQHAGNPPGVTAVDQQEQAAYDGAIDLFRKGQYKDAAESLAAFIALYPNSQLAPTAQFYLGSSRYAMKDFKGAIEQLNNLVQNAPTNARAPDALLVIAGSQIELNNRAGAKTTLQRIVRDYPTTPAANTAKSRLQLLQ
>NZ_CP016431.1|WP_068927110.1|4262067_4263117_+|iron-ABC-transporter-permease
MAAAAPDAVRAYGRLLRRRRWLMAALAAAACAALAADAALGPAGLTLAELWRALLQPGAADTAARVIVWDIRLPQAAMAAIVGMALGLAGAEMQTILNNPLASPFTLGVSSAAALGASLAIVLHVGLPGVAGAWLVPLYAFLFAALAGLLLDQVARRRAIGAPAIVLFGIALVFTFNALISLIQFTASAQALQNLVFWTMGSMARADWASVGILAAACALALPLALRHAWRLTALRLGETRAASFGVDVRRLRLAALCRISLLAALAVAFAGTIGFIGLVAPHIARRLFGEDHRFYLPGSALTGALILSLAASVSKSLVPGVIVPVGIVTSLVGIPFFVAVLLRRPQSL
>NZ_CP016431.1|WP_033463934.1|4263113_4263905_+|ABC-transporter-ATP-binding-protein
MNAPGLAIEGLGVAYGARTVIASLDLGPLPHGTLTALLGPNGSGKSTLLKAVAGLLPARGGAIALDGLRLDQAGLAQRAQHVAYLPQGLPADVHLRVFESVLVAARAHGEAAGQAGPPAVAALLERLGIGHLALQFLDELSGGQKQLVGLAQALIRRPRVLLLDEPLSALDPNYQFHVMDLLRQETRRHGLITIAALHDINVALRHADQALLIRAGELAAAGEPAAVIDAPMLARVYGIQARVERCSRGHPHVLVDGVAGPVR
>NZ_CP016431.1|WP_033463937.1|4264072_4265059_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MSGSRCFTLARLIAPVFAAAALAAAPASAADFPSRPIKLVVPAPPGGAGDISARAIAEGMGAKLGQPVIVENRPGAATLLGLRAVVRDQPDGYTMALLPVTGVAIATTMYDNVPSLEKDFSYVAGVVNAPHMLVAPAGQQSATVTELVARLKAAPGRYNYASQGVGSLSHLESALFLDGSKAQAEHVPYKGSAEALPGLMSGETAFMFDSVASVRTHVAAGKLVALATSASGRVPQFPDIPTMAELGVTDLKADNPFAFVTPAGTPPAVVAVLTDAVRTALEDPKIIETLTRAGMVPAFHPPKDIARIAADDLAFWPGLARRVGAKKE
>NZ_CP016431.1|WP_033463939.1|4265063_4266665_+|gamma-glutamyltransferase-family-protein
MTASHPLDWTFPYVSQRMPALGENMVCTEQPLANQAAMRMLAAGGNAVDAAIAAAITMTVVGPCMNGIGGDLFAIIWDGRQLHGLNASGRAPQAWTREYFSRHDAMPARGWDAVTVPGAVSGWVALSRKFGKLDFARLFEPALHYARHGFLVTPITARQWADQAEPIMQGPGFRDAFAPNGRTPQPGERFICPGQADTLQDIADTHGESFYRGALAARIAAFARETGGALTEADLAAHQADWVDPIGAQYGELTLHEIGPSGQGIGALMALGMLDGLSGKLGQPDSTDFYHYQIEAMKLAFADINRYVADPASMREVSAEMLLDRAYLAARAGAISPTEARYPGPGKPHNGGTTYLTAADADGMMVSLIQSNFKGFGSGVVVPGTGIALHNRGWGFNLIEGHPNEVGPGKRPFHTIIPGFLMRGGAPLMSFGVMGGSLQAQGHVQVTVRTAAGQNPQAVVDAPRWRILEDNRTVMVEWNFPDAAVAGLRGRGHAVTVAPRFSDEFGGSQAIMRIEGGYLGASDHRKDGQASAL
>NZ_CP016431.1|WP_033463942.1|4266675_4267131_-|MarR-family-transcriptional-regulator
MDKSTQAASRLLAFRFLSTSQLLYRSLELMMGRELGLSVRQWRVMFFLANDGVGSVQEIADFCRYDKSQVSRALQELTDKAYVNRVPSAHDRRKVLASLTPAGIEVYRQGLRISLARDERMKRALSADELAAFNATLDKLAEQAQAIMDEL
>NZ_CP016431.1|WP_094771339.1|4267226_4268489_+|FAD-binding-oxidoreductase
MGSMSKEIIVLGAGMVGVCAALHLQRRGHRVTLVDRREPGLETSYGNAGIIQREAVEPYAFPRGLATLLRVALRRGFDIRYHWGALPALLPRLAAYYAASAPRRYRPIALAYGQIIAHCTHEHQALIDASGCGDLIRRTGFRSLFRGAAGLAAATREARRLADECGVALAIESATDLEQAEPALRPGVSAGAIHWQEPWSVADPGALVAAYAERFQAEGGTLARGDAGTLQRTGAGWSVQIEEAAGPARREAGHAVVALGPWSDGLLRRFGYRLPLFVKRGYHRHYQCAAMPSMPVQDADCGFVLSPMRRGLRLATGAELARQDAPPTPVQLARAETAARDLYALGEPAEPDFWMGSRPCTVDMLPVIGAAPRHPGLWFNLGHGHQGFTLGPVSGRLLAELVDGAPTVVDAAPYSPARFG
>NZ_CP016431.1|WP_033463947.1|4268501_4269002_-|YbaK/EbsC-family-protein
MAEDEPNSLPESALRVARLLREMGHDRPVIMLPQTGKTSAEAAAGLGCEVAQIAKSIIFRRAADDAPVLVIASGVNRVDEAKVAARVGGLAKADAKFVRAMTGYAIGGVCPIGHAVRPVMLLDEDLFRYDSLWAAAGHPHAVFSLTPRQLADMTGAPVADVAQRAA

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Crispr_ID: NZ_CP016431_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016431_6

4258819-4259063

Orphan

Consensus_repeat	Method
GCCAAGGAAGAGGCCGCCAAGAA	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP016431_6

>merge|NZ_CP016431|6|4258819-4259063|CRISPRCasFinder
GCCGAGAAAGCCGCGGCGGAGAAGGCGGCCGCCGAGAAGCAGGCCGCCGAAAAGAAAGCCAAGGAAGAGGCCGCCAAGAAAGCCGAGGCCGAGAAGAAGGCCGAAGCGGAGAAGAAAGCCGAGGCCGAGAAAAAGGCCAAGGAAGAGGCGGCCAAGAAGGCTGCCGCGGAGAAAGCCGCGGCCGAGAAGGCGGCCGCCGAGAAGAAAGCCAAGGAAGAAGCCGCCAAGAAGGCGGCCGCCGACAA

>NZ_CP016431|6|6|4258819-4259063|CRISPRCasFinder
GCCGAGAAAGCCGCGGCGGAGAA	GGCGGCCGCCGAGAAGCAGGCCGCCGAAAAGAAA
GCCAAGGAAGAGGCCGCCAAGAA	AGCCGAGGCCGAGAAGAAGGCCGAAGCGGAGAAGAAAGCCGAGGCCGAGAAAAAG
GCCAAGGAAGAGGCGGCCAAGAA	GGCTGCCGCGGAGAAAGCCGCG
GCCGAGAAGGCGGCCGCCGAGAA	GAAAGCCAAGGAAGAAGCC
GCCAAGAAGGCGGCCGCCGACAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016431.1\|WP_033463928.1\|4261378_4262068_+\|tol-pal-system-protein-YbgF	unknown	unknown	gnl\|CDD\|224643
NZ_CP016431.1\|WP_033450566.1\|4253625_4254312_-\|response-regulator	unknown	unknown	gnl\|CDD\|185376
NZ_CP016431.1\|WP_010931417.1\|4259446_4260763_+\|Tol-Pal-system-protein-TolB	unknown	unknown	gnl\|CDD\|235083
NZ_CP016431.1\|WP_033463934.1\|4263113_4263905_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP016431.1\|WP_033463942.1\|4266675_4267131_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP016431.1\|WP_068927108.1\|4260794_4261292_+\|peptidoglycan-associated-lipoprotein-Pal	unknown	unknown	gnl\|CDD\|274307
NZ_CP016431.1\|WP_094771339.1\|4267226_4268489_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NZ_CP016431.1\|WP_033463919.1\|4254292_4254865_-\|RNA-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|234820
NZ_CP016431.1\|WP_033463939.1\|4265063_4266665_+\|gamma-glutamyltransferase-family-protein	unknown	unknown	gnl\|CDD\|223482
NZ_CP016431.1\|WP_068927105.1\|4257826_4258285_+\|protein-TolR	unknown	unknown	gnl\|CDD\|274306
NZ_CP016431.1\|WP_068927103.1\|4256715_4257144_+\|tol-pal-system-associated-acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|274304
NZ_CP016431.1\|WP_033463947.1\|4268501_4269002_-\|YbaK/EbsC-family-protein	unknown	unknown	gnl\|CDD\|239825
NZ_CP016431.1\|WP_068927101.1\|4254930_4256661_+\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NZ_CP016431.1\|WP_068927098.1\|4249438_4249840_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341115
NZ_CP016431.1\|WP_068927100.1\|4250080_4252057_+\|DUF3120-domain-containing-protein	unknown	unknown	gnl\|CDD\|151953
NZ_CP016431.1\|WP_033463937.1\|4264072_4265059_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP016431.1\|WP_094771338.1\|4252082_4253594_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|273593
NZ_CP016431.1\|WP_068927110.1\|4262067_4263117_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223682
NZ_CP016431.1\|WP_003814641.1\|4257146_4257827_+\|protein-TolQ	unknown	unknown	gnl\|CDD\|131843
NZ_CP016431.1\|WP_068927096.1\|4247754_4248384_-\|FMN-dependent-NADH-azoreductase	unknown	unknown	gnl\|CDD\|234675

Protein	Function_ID	Function_description	E-value
NZ_CP016431.1\|WP_033463928.1\|4261378_4262068_+\|tol-pal-system-protein-YbgF	gnl\|CDD\|224643	COG1729, COG1729, Uncharacterized protein conserved in bacteria [Function unknown].	7.65637e-31
NZ_CP016431.1\|WP_033450566.1\|4253625_4254312_-\|response-regulator	gnl\|CDD\|185376	PRK15479, PRK15479, transcriptional regulator TctD.	2.87323e-80
NZ_CP016431.1\|WP_010931417.1\|4259446_4260763_+\|Tol-Pal-system-protein-TolB	gnl\|CDD\|235083	PRK02889, tolB, Tol-Pal system protein TolB.	0
NZ_CP016431.1\|WP_033463934.1\|4263113_4263905_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.20539e-82
NZ_CP016431.1\|WP_033463942.1\|4266675_4267131_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.85425e-15
NZ_CP016431.1\|WP_068927108.1\|4260794_4261292_+\|peptidoglycan-associated-lipoprotein-Pal	gnl\|CDD\|274307	TIGR02802, Peptidoglycan-associated_lipoprotein, peptidoglycan-associated lipoprotein. Members of this protein are Pal (also called OprL), the Peptidoglycan-Associated Lipoprotein of the Tol-Pal system. The system appears to be involved both in the maintenance of outer membrane integrity and in the import of certain organic molecules as nutrients. Members of this family contain a hydrodrophobic lipoprotein signal sequence, a conserved N-terminal cleavage and modification site, a poorly conserved low-complexity region, together comprising about 65 amino acids, and a well-conserved C-terminal domain. The seed alignment for this model includes only the conserved C-terminal domain.	6.04549e-54
NZ_CP016431.1\|WP_094771339.1\|4267226_4268489_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	5.34833e-40
NZ_CP016431.1\|WP_033463919.1\|4254292_4254865_-\|RNA-pyrophosphohydrolase	gnl\|CDD\|234820	PRK00714, PRK00714, RNA pyrophosphohydrolase; Reviewed.	6.38944e-95
NZ_CP016431.1\|WP_033463939.1\|4265063_4266665_+\|gamma-glutamyltransferase-family-protein	gnl\|CDD\|223482	COG0405, Ggt, Gamma-glutamyltransferase [Amino acid transport and metabolism].	0
NZ_CP016431.1\|WP_068927105.1\|4257826_4258285_+\|protein-TolR	gnl\|CDD\|274306	TIGR02801, Protein_TolR, TolR protein. The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	1.03484e-45
NZ_CP016431.1\|WP_068927103.1\|4256715_4257144_+\|tol-pal-system-associated-acyl-CoA-thioesterase	gnl\|CDD\|274304	TIGR02799, Acyl-CoA_thioesterase_YbgC, tol-pal system-associated acyl-CoA thioesterase. The tol-pal system consists of five critical genes. Inner membrane proteins TolQ and TolR convert protomotive force to energy that is transduced through TolA to an outer membrane complex of TolB and Pal. The system is known to be required to maintain outer membrane integrity. In a system with several homologous parts, ExbB and ExbD transduces energy through TonB to a variety of outer membrane proteins, many of which are siderophore receptors. The tol-pal system therefore may also be involved in transport. This family consists of a protein nearly always found in operons with the genes of the tol-pal system. The significance of this thioesterase to the tol-pal system is unclear, but either of two observations may be relevant. First, Pal, or peptidoglycan-associated lipoprotein, has a conserved N-terminal cleavage and acylation that makes it a lipoprotein. Second, the tol-pal system is implicated not only in the import of certain organics but also in the maintenance of outer membrane integrity (by an unknown mechanism).	6.3702e-67
NZ_CP016431.1\|WP_033463947.1\|4268501_4269002_-\|YbaK/EbsC-family-protein	gnl\|CDD\|239825	cd04333, ProX_deacylase, This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro) deacylase and also the cis-acting prolyl-tRNA synthetase-editing domain (ProRS-INS). While ProX and ProRS-INS hydrolyze misacylated Ala-tRNA(Pro), the E. coli YbaK hydrolyzes misacylated Cys-tRNA(Pro). A few CD members are N-terminal, YbaK-ProX-like domains of an uncharacterized protein with a C-terminal, predicted Fe-S protein domain.	5.9449e-60
NZ_CP016431.1\|WP_068927101.1\|4254930_4256661_+\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NZ_CP016431.1\|WP_068927098.1\|4249438_4249840_-\|hypothetical-protein	gnl\|CDD\|341115	cd17032, T3SC_IA_SycT-like, Class IA type III secretion system chaperone protein, similar to Yersinia enterocolitica SycT. This family includes type III secretion system (T3SS) chaperone proteins similar to Yersinia enterocolitica SycT and similar proteins. In Y. enterocolitica, a food-borne pathogen causing gastroenteritis and mesenteric lymphadenitis, chaperone SycT promotes translocation of effector YopT (Yersinia outer protein T), a cysteine protease that inactivates the small GTPase RhoA of targeted host cells by cleaving its C-terminal, prenylated cysteine, thereby releasing the GTPase into the host cytosol.	1.01893e-32
NZ_CP016431.1\|WP_068927100.1\|4250080_4252057_+\|DUF3120-domain-containing-protein	gnl\|CDD\|151953	pfam11516, DUF3220, Protein of unknown function (DUF3120). This family of proteins with unknown function appears to be restricted to Bordetella.	2.85885e-59
NZ_CP016431.1\|WP_033463937.1\|4264072_4265059_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	2.27674e-102
NZ_CP016431.1\|WP_094771338.1\|4252082_4253594_-\|sensor-histidine-kinase	gnl\|CDD\|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	1.03135e-45
NZ_CP016431.1\|WP_068927110.1\|4262067_4263117_+\|iron-ABC-transporter-permease	gnl\|CDD\|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	7.46256e-71
NZ_CP016431.1\|WP_003814641.1\|4257146_4257827_+\|protein-TolQ	gnl\|CDD\|131843	TIGR02796, Protein_TolQ, TolQ protein. TolQ is one of the essential components of the Tol-Pal system. Together with TolR, it harnesses protonmotive force to energize TolA, which spans the periplasm to reach the complex of TolB and Pal at the outer member. The tol-pal system proves to be important for maintaining outer membrane integrity. Gene pairs similar to the TolQ and TolR gene pair often number several per genome, but this model describes specificially TolQ per se, as found in tol-pal operons. A close homolog, excluded from this model, is ExbB of the ExbB/ExbD/TonB protein complex, which powers transport of siderophores and vitamin B12 across the bacterial outer membrane. The Tol-Pal system is exploited by colicin and filamentous phage DNA to enter the cell. It is also implicated in pathogenesis in several bacterial species [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	5.36586e-98
NZ_CP016431.1\|WP_068927096.1\|4247754_4248384_-\|FMN-dependent-NADH-azoreductase	gnl\|CDD\|234675	PRK00170, PRK00170, azoreductase; Reviewed.	1.21229e-83

>NZ_CP016431.1|WP_068927105.1|4257826_4258285_+|protein-TolR
MPSVRSNGRAGRRMKADINVVPYIDVMLVLLVIFMVTAPLITPGLIELPSVGQASDVPAKPLEVQISEDGKIALRMREPGATPQDIARTELVNQVRSRITAETPVVIAADGKVPYESVVKVMDELRSSGITRLGLLVDQGAGAETQQPARKR
>NZ_CP016431.1|WP_003814641.1|4257146_4257827_+|protein-TolQ
MQVTNDMSLLSLISHASVPVQLIMLLLLGISIMSWTYIFAKRLAIKRAHQQTRRFEDDFWSGGDLAMLQQAVATRRDEQGALARIFDAGMTEFLKARRTSAAGDVNAVLDGPRRAMRAAYQREMDSLESHLNFLASAGSVSPYIGLLGTVWGIMHAFIGLSNMQQATLAAVAPGIAEALIATAIGLFAAIPAVVAYNRFTNDIDRLSIRFDSFVDEFLNILQRQVR
>NZ_CP016431.1|WP_068927103.1|4256715_4257144_+|tol-pal-system-associated-acyl-CoA-thioesterase
MTDPKFSESVLDIRVYYEDTDAGGVVFYANYLKFLERARTEWLRGLGVNQSDLAEREHRLFVVHSLDMSYRKPARLDDLITIRSRITRIGRASIHFAQRAERNGELLAEGNIQICCVDSIRMRPAELPDDIRAKLKFIQIQE
>NZ_CP016431.1|WP_068927101.1|4254930_4256661_+|proline--tRNA-ligase
MRASKYHLNTLKEAPAEAEIASHQLMTRAGMIRKLAGGIYTYMPLGLKVIRKIEGIVREEMNAAGAIELLMPVVQPAELWMESGRWEQYGAELLRIKDRHQRDFVLQPTSEEVITDIARNEIQSYRQLPLNFYHIQTKFRDERRPRFGLMRGREFTMKDAYSFDRDEAGAQRSYDIMYAAYQRIFQRLGLEFRAVAADTGSIGGSRSHEFQVIADTGEDLIVYNPESDYAANIELAEAPALLATRPAPAQDLEAVPTPGAAKCEDVAKLLGLPLARTIKSIVLAVDQPEGPAQVWLLLLRGDHELNEIKAGKLAGLAGFRFATETEITDHFGCKPGYLGPIKTARPVRVVADRTVANMADFVCGANREDYHYQGANWGRDMPEPELVADLRNVVEGDPSPDGKGTLSIQRGIEVGHVFFLGTKYSEALKATFLDDNGKPAVLQMGCYGIGVTRIVGAAIEQNHDARGIIWPRAIAPYEVVICPVGWGKSETVRDTAVALYEALRARGVDVMLDDRDSRPGVMFAEWELIGVPLRVTVGERGLNEGVVELQARREAEAAKVPVDQALAQTLAKLDLL
>NZ_CP016431.1|WP_033463919.1|4254292_4254865_-|RNA-pyrophosphohydrolase
MLDREGYRPNVGIILVNGKNEVFWGKRIREHAWQFPQGGIKYGESPVQAMYRELHEEVGLKPEHVRILGRTRDWLRYNVPDHFVRREWRGHYKGQKQIWFLLRLVGRDSDVCLRATQHPEFDAWRWSQYWVPLDAVIEFKRDVYTQALNELAVILFRRHHETRYLRQRVHGPRSTDNPSSETDDHAHIAG
>NZ_CP016431.1|WP_033450566.1|4253625_4254312_-|response-regulator
MRILLVEDERDMAAWLMRALAQSGFMPDHAPDARTAEGLMAGNEYDAVVMDLRLPDKHGLVLLREMRNRDDRTPVLLLTAQGALQDRVRGLNLGADDFLTKPFALEELEARLTALVRRSRGRQPPRLQCGSLSYDGESRAFTLDGALLFLTPREHAALAALLTRSGYPVDKSQLFGKVFTHESEANPDAIEVVLHRLRKKLTGSDVRIVTVRGLGYMLESTVSESSES
>NZ_CP016431.1|WP_094771338.1|4252082_4253594_-|sensor-histidine-kinase
MGIRALLISLLLPGVVVLLVIDSWNDYRTLAAITNEAYDSALLEPARVLESSLEFAADGTLQVATPLYAQVMLESKAGMRKYYRIEEIDPPWPENLPGMPREPGRALSGMPEMPRPPYWPRSNGQPVFFDAVYRNDPVRAVAVVRDLYYRNQHRQVLVVVAESIGKRVEAEASAQRQEVLRDARMLALVALLVWWGVNWALRPLVRLRNDIRTRRPDDLTPLDATRVPSEVAPLVEAVNHHIARHRRVLDEQSQFLADASHQLRTPLAIMLTQAQYALRERDPVRAQEGLRAIVDQLGRTRRLTEQLLSLAHASQADAPPRQELDLNDVARDVVLQYLPLAHEKQQDLGWVDARGDKAEGASDTAVVPVWGSEVELHEALSNLVHNAINYAPAGAHITVSVVRYADRAEVQVADDGPGIEPLLRARAFARFDRMAGDRHASSSGSGLGLSIARAYARRNDGDIELRDGEPNAQGGVGLCAVFWIPLYDRGAPADEAEAPRRYG
>NZ_CP016431.1|WP_068927100.1|4250080_4252057_+|DUF3120-domain-containing-protein
MLSNNVNPVVGLSYRPLPETPPSGQAAAHPSMRLLEPNNDEFVRSVASPRLRHSSEALREVKHDVRQFQASGDRSLQQLRDLEVALDHWEASQPREFAKRGGMVAELRTAIDAYKQQLREHAPSHANLDVKWLDGLRAGSMALQNDVKVWMQNLEDLRTRRPDEFAARLQQSTDALYSHLEAQWATQHGAPPTASDVAGTPQWREYTAMLRERFAGLGTIRPNLTAEENAVAILNTQTQLLALQRAQEALQASLADGVSHQGDVGLLRTQLLAGMVEGLIALQQSDDDSALWSRPPAADSGGRLSVETGAKTSTDFEAPAGKAEWLRGKGISGEAVLEAFANIEMSVSGSRAGAAGEAEGSLRLYGESTARAEVSGSFEPFALSGNIGREEADGDTETSSNAVLSLNVSAELSSKLGLEAQGSVTLGRLLKLDAEGRAEVGASAEVSGTAAIEKRSDGVGVRLEGQAEAFMGMKAEGTLTANLLHSKYAETHGLTASVTGSANVGLGATAEGKLVASPGQFEMGGEVGTTLGVGGNIGWNSKVDVNASAAYAYELASAAMARFDALRASQLDHDAKTSGNDSQLNRLADNLQSHIDATSHKLDALNSAGIENRIRKVDGAAAGDGAQAAARLAAQMALVGTGADLSHDIKITALNLRA
>NZ_CP016431.1|WP_068927098.1|4249438_4249840_-|hypothetical-protein
MFPLLIRNLRHLLGLPAGADEPVTSLAIDEQWVVHIGCEDDMVTVLLPLGPAPDPLPGTALANSLAQWPPVLLDLSEQGEAILWAREHVGRLTAEQLHALLARLAARAAALMAPDAAPPASPQGTAEVAGRKA
>NZ_CP016431.1|WP_068927096.1|4247754_4248384_-|FMN-dependent-NADH-azoreductase
MKTLVILSSILGDRSNSKQLADHLLARLKQSESGGTVKIRDLAANPVPYFDGATVGALFTPAEARNAEQQRIAALSDELVAELFDADRIVFAVPVYNFNLPAQFKSYIDHIARAGVTFRYTAEGKPEGLVQGKQVLVLIARGGKSEGTPDDTMTPYLKQMLAFLGMTDVTFIAAEGMAMGELAAQEGLALARQRIDALSLDARQGLAAA
>NZ_CP016431.1|WP_010931417.1|4259446_4260763_+|Tol-Pal-system-protein-TolB
MTPAFRRADLTGFLRTYGAALILLLAAMLAWQPAQAQLRVDISGTGATQYPVAIADFAVDDTHGRALAEVIRADLTRTGQFRLINAAGSGLNVDSQVAHDDWRAKGADFLAYGSITRGPDGRYDVRYRLADTVKKGQLDGVAFSGTEQELRRVAHQIADRIYEKITGVRGVFSTRIAYVLKRGSTYELQVADADGQNPQVALRSREPIISPSWSPDGSRLAYVSFESGKPVVYVHTLATSARIPVANFKGNNSAPAWSPDGSQLAVALTRDGLSQIYIVSAGGGSNMRRITRSPGIDTEPNFTPDGRSIIFTSDRSGGPQIYQTGLDGGDARRLTFNGGYNISPRISPDGSTLLYVARRDGAFRIASLNLSSGSETLLTDGRDDQSPSFAPNGMQVLYAAIQNGRSVLAGVSSDGRVRQTLSVLNGEIREPTWGPFTR
>NZ_CP016431.1|WP_068927108.1|4260794_4261292_+|peptidoglycan-associated-lipoprotein-Pal
MKSRIAKSLTIAALAATLAACSSVPLDDKAGQAGGSGQGSATGQILDPFNPQSILAQQRSVYFDFDSYTVSDQYRGLVETHARYLASNNQQRIKIEGNTDERGGAEYNLALGQRRADAVRRMMTLLGVSDNQIETISFGKEKPKATGSSEADFAENRRADIVYQR
>NZ_CP016431.1|WP_033463928.1|4261378_4262068_+|tol-pal-system-protein-YbgF
MRDQALPLRTLVITASLALAAMAAPAHAFADDEARRAILDLRQQVQQQNEQNQRARLQLADQLHAMQQEIAQLRDQLELISRQQPNAQGGQPQHAGNPPGVTAVDQQEQAAYDGAIDLFRKGQYKDAAESLAAFIALYPNSQLAPTAQFYLGSSRYAMKDFKGAIEQLNNLVQNAPTNARAPDALLVIAGSQIELNNRAGAKTTLQRIVRDYPTTPAANTAKSRLQLLQ
>NZ_CP016431.1|WP_068927110.1|4262067_4263117_+|iron-ABC-transporter-permease
MAAAAPDAVRAYGRLLRRRRWLMAALAAAACAALAADAALGPAGLTLAELWRALLQPGAADTAARVIVWDIRLPQAAMAAIVGMALGLAGAEMQTILNNPLASPFTLGVSSAAALGASLAIVLHVGLPGVAGAWLVPLYAFLFAALAGLLLDQVARRRAIGAPAIVLFGIALVFTFNALISLIQFTASAQALQNLVFWTMGSMARADWASVGILAAACALALPLALRHAWRLTALRLGETRAASFGVDVRRLRLAALCRISLLAALAVAFAGTIGFIGLVAPHIARRLFGEDHRFYLPGSALTGALILSLAASVSKSLVPGVIVPVGIVTSLVGIPFFVAVLLRRPQSL
>NZ_CP016431.1|WP_033463934.1|4263113_4263905_+|ABC-transporter-ATP-binding-protein
MNAPGLAIEGLGVAYGARTVIASLDLGPLPHGTLTALLGPNGSGKSTLLKAVAGLLPARGGAIALDGLRLDQAGLAQRAQHVAYLPQGLPADVHLRVFESVLVAARAHGEAAGQAGPPAVAALLERLGIGHLALQFLDELSGGQKQLVGLAQALIRRPRVLLLDEPLSALDPNYQFHVMDLLRQETRRHGLITIAALHDINVALRHADQALLIRAGELAAAGEPAAVIDAPMLARVYGIQARVERCSRGHPHVLVDGVAGPVR
>NZ_CP016431.1|WP_033463937.1|4264072_4265059_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MSGSRCFTLARLIAPVFAAAALAAAPASAADFPSRPIKLVVPAPPGGAGDISARAIAEGMGAKLGQPVIVENRPGAATLLGLRAVVRDQPDGYTMALLPVTGVAIATTMYDNVPSLEKDFSYVAGVVNAPHMLVAPAGQQSATVTELVARLKAAPGRYNYASQGVGSLSHLESALFLDGSKAQAEHVPYKGSAEALPGLMSGETAFMFDSVASVRTHVAAGKLVALATSASGRVPQFPDIPTMAELGVTDLKADNPFAFVTPAGTPPAVVAVLTDAVRTALEDPKIIETLTRAGMVPAFHPPKDIARIAADDLAFWPGLARRVGAKKE
>NZ_CP016431.1|WP_033463939.1|4265063_4266665_+|gamma-glutamyltransferase-family-protein
MTASHPLDWTFPYVSQRMPALGENMVCTEQPLANQAAMRMLAAGGNAVDAAIAAAITMTVVGPCMNGIGGDLFAIIWDGRQLHGLNASGRAPQAWTREYFSRHDAMPARGWDAVTVPGAVSGWVALSRKFGKLDFARLFEPALHYARHGFLVTPITARQWADQAEPIMQGPGFRDAFAPNGRTPQPGERFICPGQADTLQDIADTHGESFYRGALAARIAAFARETGGALTEADLAAHQADWVDPIGAQYGELTLHEIGPSGQGIGALMALGMLDGLSGKLGQPDSTDFYHYQIEAMKLAFADINRYVADPASMREVSAEMLLDRAYLAARAGAISPTEARYPGPGKPHNGGTTYLTAADADGMMVSLIQSNFKGFGSGVVVPGTGIALHNRGWGFNLIEGHPNEVGPGKRPFHTIIPGFLMRGGAPLMSFGVMGGSLQAQGHVQVTVRTAAGQNPQAVVDAPRWRILEDNRTVMVEWNFPDAAVAGLRGRGHAVTVAPRFSDEFGGSQAIMRIEGGYLGASDHRKDGQASAL
>NZ_CP016431.1|WP_033463942.1|4266675_4267131_-|MarR-family-transcriptional-regulator
MDKSTQAASRLLAFRFLSTSQLLYRSLELMMGRELGLSVRQWRVMFFLANDGVGSVQEIADFCRYDKSQVSRALQELTDKAYVNRVPSAHDRRKVLASLTPAGIEVYRQGLRISLARDERMKRALSADELAAFNATLDKLAEQAQAIMDEL
>NZ_CP016431.1|WP_094771339.1|4267226_4268489_+|FAD-binding-oxidoreductase
MGSMSKEIIVLGAGMVGVCAALHLQRRGHRVTLVDRREPGLETSYGNAGIIQREAVEPYAFPRGLATLLRVALRRGFDIRYHWGALPALLPRLAAYYAASAPRRYRPIALAYGQIIAHCTHEHQALIDASGCGDLIRRTGFRSLFRGAAGLAAATREARRLADECGVALAIESATDLEQAEPALRPGVSAGAIHWQEPWSVADPGALVAAYAERFQAEGGTLARGDAGTLQRTGAGWSVQIEEAAGPARREAGHAVVALGPWSDGLLRRFGYRLPLFVKRGYHRHYQCAAMPSMPVQDADCGFVLSPMRRGLRLATGAELARQDAPPTPVQLARAETAARDLYALGEPAEPDFWMGSRPCTVDMLPVIGAAPRHPGLWFNLGHGHQGFTLGPVSGRLLAELVDGAPTVVDAAPYSPARFG
>NZ_CP016431.1|WP_033463947.1|4268501_4269002_-|YbaK/EbsC-family-protein
MAEDEPNSLPESALRVARLLREMGHDRPVIMLPQTGKTSAEAAAGLGCEVAQIAKSIIFRRAADDAPVLVIASGVNRVDEAKVAARVGGLAKADAKFVRAMTGYAIGGVCPIGHAVRPVMLLDEDLFRYDSLWAAAGHPHAVFSLTPRQLADMTGAPVADVAQRAA

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Crispr_ID: NZ_CP016431_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016431_7

4561941-4562024

Orphan

Consensus_repeat	Method
GGTGCCTGTCCCCGCGGGGACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016431_7

>merge|NZ_CP016431|7|4561941-4562024|CRISPRCasFinder
GGTGCCTGTCCCCGCGGGGACAGATACCGTCTTGGCCGTCAAGCGTTCTGGCGTATGACGGGGTGCCTGTCCCCGCGGGGACAG

>NZ_CP016431|7|7|4561941-4562024|CRISPRCasFinder
GGTGCCTGTCCCCGCGGGGACAG	ATACCGTCTTGGCCGTCAAGCGTTCTGGCGTATGACGG
GGTGCCTGTCCCCGCGGGGACAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016431.1\|WP_033466584.1\|4564029_4564776_+\|pyrimidine-5'-nucleotidase	unknown	unknown	gnl\|CDD\|319791
NZ_CP016431.1\|WP_033466579.1\|4560690_4561434_+\|BON-domain-containing-protein	unknown	unknown	gnl\|CDD\|182907
NZ_CP016431.1\|WP_068927294.1\|4559564_4560092_+\|YraN-family-protein	unknown	unknown	gnl\|CDD\|173148
NZ_CP016431.1\|WP_033461704.1\|4557990_4558563_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NZ_CP016431.1\|WP_068927296.1\|4567117_4568173_+\|Ldh-family-oxidoreductase	unknown	unknown	gnl\|CDD\|376860
NZ_CP016431.1\|WP_003815188.1\|4560091_4560694_+\|phosphoheptose-isomerase	unknown	unknown	gnl\|CDD\|237567
NZ_CP016431.1\|WP_003815183.1\|4556174_4557047_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|235450
NZ_CP016431.1\|WP_033461707.1\|4558559_4559498_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NZ_CP016431.1\|WP_086094502.1\|4555250_4556003_-\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|225418
NZ_CP016431.1\|WP_033466585.1\|4564825_4565401_+\|nucleoid-occlusion-factor-SlmA	unknown	unknown	gnl\|CDD\|181894
NZ_CP016431.1\|WP_033466596.1\|4571843_4572728_-\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560
NZ_CP016431.1\|WP_033466582.1\|4562078_4562867_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP016431.1\|WP_033466588.1\|4565613_4567107_+\|DASS-family-sodium-coupled-anion-symporter	unknown	unknown	gnl\|CDD\|279307
NZ_CP016431.1\|WP_003815201.1\|4569327_4571280_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_CP016431.1\|WP_003815193.1\|4563127_4564030_+\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|234869
NZ_CP016431.1\|WP_033466581.1\|4561430_4561922_+\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_CP016431.1\|WP_033466594.1\|4571293_4571857_-\|rod-shape-determining-protein-MreD	unknown	unknown	gnl\|CDD\|274574
NZ_CP016431.1\|WP_068927292.1\|4553953_4555240_-\|cytochrome-c	unknown	unknown	gnl\|CDD\|224921
NZ_CP016431.1\|WP_033461702.1\|4557043_4557994_+\|septal-ring-lytic-transglycosylase-RlpA-family-protein	unknown	unknown	gnl\|CDD\|223868
NZ_CP016431.1\|WP_068927298.1\|4568194_4569331_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033

Protein	Function_ID	Function_description	E-value
NZ_CP016431.1\|WP_033466584.1\|4564029_4564776_+\|pyrimidine-5'-nucleotidase	gnl\|CDD\|319791	cd02604, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to Saccharomyces cerevisiae Phm8p and Sdt1p. This family includes Saccharomyces cerevisiae Phm8p (phosphate metabolism protein 8) and Sdt1p (Suppressor of disruption of TFIIS). Phm8p participates in the ribose salvage pathway, it catalyzes the dephosphorylation of nucleotide monophosphates to nucleosides, its preferred substrates are nucleotide monophosphates AMP, GMP, CMP, and UMP. Phm8p is also a lysophosphatidic acid phosphatase, dephosphorylating lysophosphatidic acids (LPAs) to monoacylglycerol in response to phosphate starvation. Sdt1p is a pyrimidine and pyridine-specific 5'-nucleotidase; it is an NMN/NaMN 5'-nucleotidases involved in the production of nicotinamide riboside and nicotinic acid riboside, and is a pyrimidine 5'-nucleotidase with high specificity for UMP and CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.1321e-47
NZ_CP016431.1\|WP_033466579.1\|4560690_4561434_+\|BON-domain-containing-protein	gnl\|CDD\|182907	PRK11023, PRK11023, divisome-associated lipoprotein YraP.	3.14241e-43
NZ_CP016431.1\|WP_068927294.1\|4559564_4560092_+\|YraN-family-protein	gnl\|CDD\|173148	PRK14685, PRK14685, hypothetical protein; Provisional.	1.06733e-75
NZ_CP016431.1\|WP_033461704.1\|4557990_4558563_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	2.06235e-53
NZ_CP016431.1\|WP_068927296.1\|4567117_4568173_+\|Ldh-family-oxidoreductase	gnl\|CDD\|376860	pfam02615, Ldh_2, Malate/L-lactate dehydrogenase. This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyzes the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyzes the reactions: (S)-malate + NAD(+) <=> oxaloacetate + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively.	2.93188e-126
NZ_CP016431.1\|WP_003815188.1\|4560091_4560694_+\|phosphoheptose-isomerase	gnl\|CDD\|237567	PRK13936, PRK13936, phosphoheptose isomerase; Provisional.	1.25469e-125
NZ_CP016431.1\|WP_003815183.1\|4556174_4557047_+\|RNase-adapter-RapZ	gnl\|CDD\|235450	PRK05416, PRK05416, RNase adapter RapZ.	1.18739e-149
NZ_CP016431.1\|WP_033461707.1\|4558559_4559498_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	7.39318e-109
NZ_CP016431.1\|WP_086094502.1\|4555250_4556003_-\|c-type-cytochrome	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	7.90654e-13
NZ_CP016431.1\|WP_033466585.1\|4564825_4565401_+\|nucleoid-occlusion-factor-SlmA	gnl\|CDD\|181894	PRK09480, slmA, division inhibitor protein; Provisional.	1.36894e-107
NZ_CP016431.1\|WP_033466596.1\|4571843_4572728_-\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	8.35973e-90
NZ_CP016431.1\|WP_033466582.1\|4562078_4562867_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	2.87828e-136
NZ_CP016431.1\|WP_033466588.1\|4565613_4567107_+\|DASS-family-sodium-coupled-anion-symporter	gnl\|CDD\|279307	pfam00939, Na_sulph_symp, Sodium:sulfate symporter transmembrane region. There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.	8.79928e-116
NZ_CP016431.1\|WP_003815201.1\|4569327_4571280_-\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP016431.1\|WP_003815193.1\|4563127_4564030_+\|acetylglutamate-kinase	gnl\|CDD\|234869	PRK00942, PRK00942, acetylglutamate kinase; Provisional.	1.71108e-158
NZ_CP016431.1\|WP_033466581.1\|4561430_4561922_+\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	3.46157e-41
NZ_CP016431.1\|WP_033466594.1\|4571293_4571857_-\|rod-shape-determining-protein-MreD	gnl\|CDD\|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	3.69381e-19
NZ_CP016431.1\|WP_068927292.1\|4553953_4555240_-\|cytochrome-c	gnl\|CDD\|224921	COG2010, CccA, Cytochrome c, mono- and diheme variants [Energy production and conversion].	1.24489e-08
NZ_CP016431.1\|WP_033461702.1\|4557043_4557994_+\|septal-ring-lytic-transglycosylase-RlpA-family-protein	gnl\|CDD\|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	1.40267e-54
NZ_CP016431.1\|WP_068927298.1\|4568194_4569331_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	2.85531e-160

>NZ_CP016431.1|WP_033466581.1|4561430_4561922_+|TlpA-family-protein-disulfide-reductase
MKKIALVLIIAVAAGIGGWFMWRPAQTAPDVAFTTLEGQKITMQDLRGKVVLVKFWATSCVTCVKQMPDNIANYNQYHPQGYETIAVAMNYDPPNYVLNFAQTRKLPFPVALDTSGELAQAFGNVRLTPTAFLIDKHGQIIKRYLGEYDKAEFQATVQKALAG
>NZ_CP016431.1|WP_033466579.1|4560690_4561434_+|BON-domain-containing-protein
MMPDAKTAARPLLLAAALSAAALTLSACAPLVIGGAAATTAVVVTDRRTSGVQLEDQNIAFKAESQIAQKLGNTARVNAMVYGGHVLLTGDAPTEEAKAQATSIAQSIENVKAVTNQLTVGPAADFSTRSNDTWLTSKVKTALINTKYVPSGTISVTTSRGVVYLMGKVTQAEGDYAANAAAGVGGVVRVVKLFETISREEAIRLSGSGTKSGEGSSDGTAPQKAPIESGAAPAGGGSSGVEAIPIK
>NZ_CP016431.1|WP_003815188.1|4560091_4560694_+|phosphoheptose-isomerase
MRAMDMTSRMTSHFRDAMALCEQSADALAAPLAAAVDLLFAALANNGRILACGNGGSAADAQHFIAELVGRFERERLPLAGIALNTDTSIMTAVGNDYGFDEIFERQVHALGQPGDVLVAISTSGNSPNVVRAMETAREREMHVIALTGKGGGVMGELITPHDVHLCVPHDRTMRIQEVHIILLHALCDGIDALLLGDTE
>NZ_CP016431.1|WP_068927294.1|4559564_4560092_+|YraN-family-protein
MTDTATRLAFDRAAQAQRRLRHRPPPPSRTGPGAGGSPTQRRGQAHESAALRWLVTQGLRPLARNLRCRAGEIDLAMRDGGVLVLVEVRARAHAGYGGAAASVGASKQGRLARAAALLLPGLLRRHWPGAPPPVRFDVVAFEAGRPRWLRGAFWLAEHGPARRRRGQDTEDWRVR
>NZ_CP016431.1|WP_033461707.1|4558559_4559498_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MNQDVLSPAPGDAWSRVADRVAAQHWPAATLYVIATPIGNLGDLGLRAWQALVRADVIAAEDTRASRTLLDAWGVTTPLMAAHRHNEASAAQAICERLAQGQRVALVSDAGAPAVSDPGARIVRAVREAGHAVVPVPGPSAVIAALMGSGATSDENPAFAFAGFPPAKAVARQRWLRQWCALPAPVVMFESPHRLAATLADLREAGGPARLLTVARELTKRFEEIATMPLGEAADWLAADAHRGQGEFVLIVHQAPGAQDDEADPADPRTDALLDALLESLSVRDAARVAAKVTGLARDVLYARALARKEQA
>NZ_CP016431.1|WP_033461704.1|4557990_4558563_-|methylated-DNA--[protein]-cysteine-S-methyltransferase
MNPPSEQATDILYCDTDTPLGPMRLAARAQALCGAWFVDQRDCPAAAGWTLDAAHPALRQAAAELEQWFAGQRREFEVAMQPEGTPFQRQVWQALLELPFGATISYGELARRVGRPKAARAVAGAVGRNPISILIPCHRIIGHDTSLTGFGGGLPRKQALLAHEGHRYLSRAARARRVSTTQMELPFGAV
>NZ_CP016431.1|WP_033461702.1|4557043_4557994_+|septal-ring-lytic-transglycosylase-RlpA-family-protein
MIRSRPLALLSTLLLALAIAGCSTPGKKRGGYYKDDGPDANPPSNLDNIPDATPRLEPLASGPNRPYVVFGKRYVPDTSERPFRQQGLASWYGKKFHGNSTSNGESYDMYAMTAAHPTMPIPSYARVTSKLNGRTVIVRVNDRGPFHSDRIMDLSYVAAHKLGIIGPGSGPVTVERILPAEILAMNGGTPAPRPGSAPASGALPIAAPSAAAAVELPAATQLASNAPTPPRPATGADSGIYLQLGAFSQPANAESLVSRINGQLDPASGIPPAVVEQANNLYRVRIGPYATREAALGAVQPVADRTGILPSLSATP
>NZ_CP016431.1|WP_003815183.1|4556174_4557047_+|RNase-adapter-RapZ
MLRVVLITGISGSGKSVALRLLEDAGFTCIDNLPVRFLAEFIANARDDAMERVAVAIDVRSPGELAELPDVITASRAMGTSLSVIFLDANTDTLVQRYSESRRRHPLTDRLARGGKTPSLAECIALERELMAPLRDQEHVIDTSDLTPGQLRAWIRDLIQADRPPLVLTFESFAYKRGVPSDADLMFDVRCLPNPYYDRTLRPLTGRDEPVATWLGGFDIVTQMIDDIAAFIRRWLPQYTQDTRNYLTVAIGCTGGQHRSVYVVEQLARRFSDHDPLLVRHRTQLPDDPA
>NZ_CP016431.1|WP_086094502.1|4555250_4556003_-|c-type-cytochrome
MLAFKSDLRIAMRAWRAACGALAAAAGMLAMSQAAAQGEAVLRPDTMAARVAACTACHGEQGRAGPDGYYPRLAGKPQDYLYHQLLNFRDARRQYPPMEHLLDGLPDAYLREMAAYFAGQDVPYPAPARIEASAALVERGRLLVREGDPARDIPSCASCHGASLAGVAPAIPGLLGLPRDYLVAQIGSWQNGLRRAAAPDCMAQVSLKLTPEDIGAVSAWLAGQPVGHPYTPQPAGSLALPLECGSQAGH
>NZ_CP016431.1|WP_068927292.1|4553953_4555240_-|cytochrome-c
MKIVKRVLVVIILALLAAAATLYWLGTRDHVPAGPQAAPATGSADELVEQGRYLARAGNCMACHTARGGQAYAGGTPIPTPFGTLYGPNITPDAETGIGGWSADDFWQALHNGKGPDGRLLYPAFPYTEYTRMTRADADALYAFLRTVEPVRQPSRPHALESPYDQRLLLAAWRALYFEPGGPQPDPGQSLQWNRGRYLTEGLGHCAACHTPRNSLGATRAAEALGGGMIDGLGWYAPPLTGQPGTGLGDWSAQDIAALLTTGIAPHSTVAGPMAEVVLGSTQYLSDDDALAIGAYLKSLPAAAQPPARRGAPSATVMELGGKMYSKSCAQCHQADGKGSFPAWPALAGNPSVIAAEPANVIRMVLDGGFAPATATNPRPHGMPPFAQALPDNDIAMLVSYVRNSWGNQAGAVTPLDVKRTRESGAGR
>NZ_CP016431.1|WP_033466582.1|4562078_4562867_-|ABC-transporter-substrate-binding-protein
MRINFVRSALLASALLLAGGAAQAEKLVVGATQVPHAEILEVVKPVLAKEGVELDIKVFTDYVQPNLQLADKQLDANFFQHQPYLDTFNKDRKTDLVSVGLVHVEPFGGYSKKIKSLAELKDGATIAIPNDPSNSGRALLLLQKQGLLKLKDPANIVATPIDIAENPKKLKFRELEAAMLPRSLDDLDLALINTNYALEAGLVPTRDALFIEGADSPYANLVAARPDNKDAPAVKKLVNALHSEAVRKFIIEKYKGAVVPAF
>NZ_CP016431.1|WP_003815193.1|4563127_4564030_+|acetylglutamate-kinase
MTDTPDPAAVLSPAVKAAVLSEALPYIRRFHGKTIVVKYGGNAMTEERLQRSFAHDVVLLKLVGLNPVVVHGGGPQIDDALRRIGKQGTFVQGMRVTDAETMEVVEWVLGGQVQQDIVMMINEVGGKAVGLTGKDGMLIQATKKLMVNKDDPSQPLDIGFVGDITRVEPAVVKALQDDQFIPVISPIGYGEDGTAYNINADVVAGKMAEVLGAEKLLMMTNTPGVLDKGGKLLRSLSAQTIDELFADGTISGGMLPKISSSLDAAKNGVNSVHIVDGRVPHCLLLEILTDQGVGTMISSH
>NZ_CP016431.1|WP_033466584.1|4564029_4564776_+|pyrimidine-5'-nucleotidase
MLARRYLLRPAARLRRSRRIATAAPERLWLFDLDNTLHDTSHAIFPLIDRGMTEAVAETLAVDEATANRLRAEYWRRYGATVIGLVRHHGVDADAFLHRSHNFEVAPLVRAETALADKLRRLPGRKVLLTNAPQHYARAVLRHLGLLRQFDSIWAIEQMRMHGQFRPKPSDALLRYVLAREGVPAARAVLIEDTLDNLRSARRVGLRTVHVFHPGTPFARGHRQRPGYVDLRVNSVSDLLLRRRPLRG
>NZ_CP016431.1|WP_033466585.1|4564825_4565401_+|nucleoid-occlusion-factor-SlmA
MASKPGERKTQILHTLAEMLEQPHAARITTSALAARMQVSEAALYRHFASKAQMFEGLIEFIETSIFTVVNQIAVSEPYGMGQARKTVSMLLAFAERNRGITRVLTGDALVTEDNRLQERINHINDRIEASLKQCLRVAVSDGALPADANIAAHASLLTHLVLGRWLRYAQSGWRVAPTTHLEEHLRLALG
>NZ_CP016431.1|WP_033466588.1|4565613_4567107_+|DASS-family-sodium-coupled-anion-symporter
MTAPAAVPAPQSPPKVKVPIGLIAGIVAMVAVLLLPLPAELPPAGHRMLAILAFAVVVWITEAVSYEASAIMITTLMAFLLGTAPSVKNPEVLYGTSAAISMALTGFSNSALALVTGALFIAAAMTFTGLDKRIALVTLARVGTSTRRILLGAIAVTIVLSLVVPSATARSAAVVPIMLGVIAAFGVDKRSNIAAGIMIIVAQATSIWNVGIQTAAAQNLLTVGFMDKMLGERVAWSDWLIAGVPWSLLMSAVLVFVVLKLLPPESDAIAGGKEAVEASLRELGPMTSAQKRLMLVSIMLLLFWSTEGKLHRFDTTSTTYFGLVLLMLPRFGVMTWKDVQTRIPWGTVIVFGVGISLGTALLTTQAGQWLGAQVVAHTGLDHLGPLGIFAILSAFLILIHLGFASATALTSAMLPILIAVLQTLPGDFNRLGMTMLLGFVVSYGFILPINAPQNMVALGTETFTAKQFAKVGILLTIVGYLLMLLMSVTYWRWLGWM
>NZ_CP016431.1|WP_068927296.1|4567117_4568173_+|Ldh-family-oxidoreductase
MKLPIAQAIAFGQRLLTAQGVPDDIARDVAEHLVESDRVGYTSHGLSILPNYRRVLAEGFVKADGRARLLNDRGAMLAFDGDNGFGQHVGKAVMQQAIERARQYGQCIVTLRRTHHLGRMGYYGEMAAEAGLILLAFTNVVNRPPTVAPYGGAQACLTTNPLCFAGPLPGGRRPFLVDMATSSIAVNKARVLAAKGEPAPDGALIDAQGNPTSDPNALFADPPGALLPFGGHKGYAMGLVAELLAGVLSGGGTIQPEHPRNGVATNNMFAILLDPQVDFNADWRTQEVGAFIDYLHACPPQPGVDRVQYPGEYEAMNRARHAEAIEFEGAIWDSLARLAQDLGVTDALPGA
>NZ_CP016431.1|WP_068927298.1|4568194_4569331_-|rod-shape-determining-protein-RodA
MKRLGLILLRVFTAFDWPLLLILILFTLLGLTVMHSAVGSTDWRFAEQSRNFLIAFAAMWAMALVPPNTLMKLALPFYVLGVILLLGVEFFGETSKGATRWLNLGVTRIQPSEMMKIAVPMMLAWYFQRHDGAVRIRDFFVAAAMLAAPFVLIVLQPDLGTALLVFGAGFFVIYFAGLSFKLLVPCLLAGIIAIGTLIYYEDQLCEPEVDWVVLHDYQKHRVCTLLNPSSDPLGKGFHTIQSMIAVGSGGLYGKGYMQGTQTHLDFIPERTTDFIFAVYAEEFGLYGGVALLVLYGLFMARGLAIAARATSQFGRLLAGAITMMMFIYVFVNVGMVTGILPVVGVPLPFMSYGGTALLTMGIACGILMSISRRRPAPA
>NZ_CP016431.1|WP_003815201.1|4569327_4571280_-|penicillin-binding-protein-2
MFEFKKTGQQQKQRFRLRAWVGGLFALACFGVLAGRFWYLQVDRYEGFSERADRNRIAVVPIPPRRGEILDRNGEVLARNYRTYTLEVVPAQAGNLDQLFDRLARVVYISPSDQRRFKRRVGESSRYASLQLRNNLNDTEAAWFSAHSFEFPGVELRARWVREYPQGEAAAHVVGFIGRIAENDIEELDKAGQLGNYRGTDVIGKKGIEKTWEAALHGRTGLEEVEVTAGGRPMRTLRRIDPVPGSDIMLSIDLELQKLAEQAFEGRRGALVALDPDTGEVLAFVSQPSFDPNLFVDGIDVENWRRLNESPDHPLINRPLYGTYPIGSTYKPFVALAALELGKRRATDRMPDPGYFEFGGQKFRNAGGAAYGMTDMHRAIVVSSDTYFYSLGPEIGVNALHDFSKQFGFGQITGIDLEGEKAGVLPSTEWKRKAYKDRDRQRWYAGETISVAVGQGYNSFTLLQLAQATSTLANSGLYRRPHLVHAIRDSRSGSVNPTEIAPDYRIPLKQENVDVIKRAMADVVRAGTARRAFAGAPYQAAGKTGTAQVFSLRGGQYRASAIDERLRDHALFMGFAPVEQPRIAVALIVENAGWGASAAAPIARTLFDNWLGRADAPSVVRAGAKPVAAEPEAAALELGATDGPMQERRQ
>NZ_CP016431.1|WP_033466594.1|4571293_4571857_-|rod-shape-determining-protein-MreD
MERTKVSVPARRKLGTPSNVEPERLARPAHGVFVWGTVLLVWLLSLLPWRQWPGSPDVLVLVIAFWCVHEPRRVGLLTAFVFGLLLDVHDAGLLGGHALSYTLTAYGAIALHRRLQRFDLWSQAMHMLPVFFVAQLVTQIILAWLAGKWPGWQWAVSVGLTAAIWPLAGWVLHMPQRRYDDVESSAV
>NZ_CP016431.1|WP_033466596.1|4571843_4572728_-|rod-shape-determining-protein-MreC
MQRQATPPLFRRGPPAEVRLAVLVILALALLIVDSQLRVLEPVRRAVSVALYPFQRAVMAPRDLVQQVDEWINAASLIRSENEALQRQRIELAQVATHAAQLAAENAQLRRLLGVTDTVAQSAVVVEVLYEPPNAFHQRLVFNKGAKSGLAPGMPVIDEGGVVGQIVRVTPMTAEAALVTDERVSIPVQVLRNGLRLIAFGANTPGVIEVRYLAANADIKVGDTIVTSGVGGLFPAGLPVAKVASVERDTASGFARALGEPLAHPERYRHFLVLQVDVDQAESNRQEADVDGTD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP016431_6	6.4\|4259022\|19\|NZ_CP016431\|CRISPRCasFinder	4259022-4259040	19	NZ_CP016431.1	2939647-2939665	2	0.895

1. spacer 6.4|4259022|19|NZ_CP016431|CRISPRCasFinder matches to position: 2939647-2939665, mismatch: 2, identity: 0.895

gaaagccaaggaagaagcc	CRISPR spacer
gaaagccctggaagaagcc	Protospacer
*******  **********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP016431_6	6.3\|4258977\|22\|NZ_CP016431\|CRISPRCasFinder	4258977-4258998	22	NZ_CP024426	Paracoccus yeei strain TT13 plasmid pTT13-4, complete sequence	59405-59426	2	0.909
NZ_CP016431_6	6.3\|4258977\|22\|NZ_CP016431\|CRISPRCasFinder	4258977-4258998	22	NZ_CP020445	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed5, complete sequence	173376-173397	2	0.909
NZ_CP016431_6	6.3\|4258977\|22\|NZ_CP016431\|CRISPRCasFinder	4258977-4258998	22	NZ_CP044079	Paracoccus yeei strain FDAARGOS_643 plasmid unnamed2, complete sequence	13049-13070	2	0.909
NZ_CP016431_6	6.3\|4258977\|22\|NZ_CP016431\|CRISPRCasFinder	4258977-4258998	22	NZ_CP031079	Paracoccus yeei strain CCUG 32053 plasmid pYEE1, complete sequence	408309-408330	2	0.909
NZ_CP016431_3	3.1\|1328842\|27\|NZ_CP016431\|CRISPRCasFinder	1328842-1328868	27	NZ_CP022417	Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-2, complete sequence	207997-208023	5	0.815
NZ_CP016431_3	3.1\|1328842\|27\|NZ_CP016431\|CRISPRCasFinder	1328842-1328868	27	NZ_CP035511	Haematobacter massiliensis strain OT1 plasmid pOT1-1, complete sequence	363793-363819	6	0.778
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NZ_CP045122	Rubrobacter sp. SCSIO 52915 plasmid unnamed1, complete sequence	48810-48843	7	0.794
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NZ_CP040937	Hymenobacter sp. DG01 plasmid unnamed, complete sequence	10459-10492	8	0.765
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NZ_CP026517	Deinococcus sp. NW-56 plasmid unnamed1, complete sequence	312591-312624	9	0.735
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NC_016587	Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence	330686-330719	10	0.706
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MN693112	Marine virus AFVG_25M205, complete genome	33502-33535	10	0.706
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MN693088	Marine virus AFVG_25M204, complete genome	33652-33685	10	0.706
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NZ_CP029833	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence	71748-71781	10	0.706
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NZ_CP040096	Pantoea sp. SO10 plasmid unnamed1, complete sequence	483969-484002	10	0.706
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MF140406	Mycobacterium phage DarthP, complete genome	59842-59875	10	0.706
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NZ_CP013109	Sinorhizobium americanum strain CFNEI 73 plasmid B, complete sequence	540870-540903	11	0.676
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NZ_CP024309	Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3b, complete sequence	33093-33126	11	0.676
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NZ_CP013054	Sinorhizobium americanum CCGM7 plasmid C, complete sequence	222765-222798	11	0.676
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MH271308	Microbacterium phage Percival, complete genome	23422-23455	11	0.676
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MH271298	Microbacterium phage Floof, complete genome	22428-22461	11	0.676
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MG812490	Mycobacterium phage Holeinone, complete genome	25723-25756	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MH001452	Mycobacterium phage Kheth, complete genome	25743-25776	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MH697584	Mycobacterium phage FrenchFry, complete genome	25861-25894	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MN813678	Mycobacterium phage Lephleur, complete genome	25741-25774	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	KT365402	Mycobacterium phage Tres, complete genome	25738-25771	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NC_043767	Mycobacterium virus TA17a, complete genome	25725-25758	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MN234225	Mycobacterium phage Rhinoforte, complete genome	25851-25884	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	KR997932	Mycobacterium phage Godines, complete genome	25741-25774	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MH590591	Mycobacterium phage Sabella, complete genome	25735-25768	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	JN618996	Mycobacterium phage Arbiter, complete genome	25819-25852	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	KX443696	Mycobacterium phage Laurie, complete genome	25732-25765	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	MH727546	Mycobacterium phage Eaglehorse, complete genome	25771-25804	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	KT880194	Mycobacterium phage Glass, complete genome	25861-25894	12	0.647
NZ_CP016431_6	6.1\|4258842\|34\|NZ_CP016431\|CRISPRCasFinder	4258842-4258875	34	NZ_CP032678	Pseudomonas sp. Leaf58 plasmid pBASL58, complete sequence	137214-137247	12	0.647

1. spacer 6.3|4258977|22|NZ_CP016431|CRISPRCasFinder matches to NZ_CP024426 (Paracoccus yeei strain TT13 plasmid pTT13-4, complete sequence) position: , mismatch: 2, identity: 0.909

ggctgccgcggagaaagccgcg	CRISPR spacer
cgctgccgcggaggaagccgcg	Protospacer
 ************.********

2. spacer 6.3|4258977|22|NZ_CP016431|CRISPRCasFinder matches to NZ_CP020445 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed5, complete sequence) position: , mismatch: 2, identity: 0.909

ggctgccgcggagaaagccgcg	CRISPR spacer
cgctgccgcggaggaagccgcg	Protospacer
 ************.********

3. spacer 6.3|4258977|22|NZ_CP016431|CRISPRCasFinder matches to NZ_CP044079 (Paracoccus yeei strain FDAARGOS_643 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.909

ggctgccgcggagaaagccgcg	CRISPR spacer
cgctgccgcggaggaagccgcg	Protospacer
 ************.********

4. spacer 6.3|4258977|22|NZ_CP016431|CRISPRCasFinder matches to NZ_CP031079 (Paracoccus yeei strain CCUG 32053 plasmid pYEE1, complete sequence) position: , mismatch: 2, identity: 0.909

ggctgccgcggagaaagccgcg	CRISPR spacer
cgctgccgcggaggaagccgcg	Protospacer
 ************.********

5. spacer 3.1|1328842|27|NZ_CP016431|CRISPRCasFinder matches to NZ_CP022417 (Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-2, complete sequence) position: , mismatch: 5, identity: 0.815

cggggaagtggcaggcgtgacggtggt	CRISPR spacer
caccgaagtggcaggcgtgaccgtggc	Protospacer
*.  ***************** ****.

6. spacer 3.1|1328842|27|NZ_CP016431|CRISPRCasFinder matches to NZ_CP035511 (Haematobacter massiliensis strain OT1 plasmid pOT1-1, complete sequence) position: , mismatch: 6, identity: 0.778

cggggaagtggcaggcgtgacggtggt	CRISPR spacer
cggggaagtgacaggcgagacggcccc	Protospacer
**********.****** *****.  .

7. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NZ_CP045122 (Rubrobacter sp. SCSIO 52915 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.794

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
tgcggcagccgagcagcaggccgccgagcagcag	Protospacer
 ***** ****** *************. ** *.

8. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NZ_CP040937 (Hymenobacter sp. DG01 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.765

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
ctcgcccgccgagcagcaggccgccggtctgaaa	Protospacer
  ** ******** ************.   ****

9. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NZ_CP026517 (Deinococcus sp. NW-56 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
cacggccgccgggcagcaggccgccgcgctggaa	Protospacer
 .*********.* ************ .  *.**

10. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NC_016587 (Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence) position: , mismatch: 10, identity: 0.706

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
gcaggccgccgacaagctggccgccgagggcgga	Protospacer
*  ********* **** *********... ..*

11. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MN693112 (Marine virus AFVG_25M205, complete genome) position: , mismatch: 10, identity: 0.706

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
agtagccgccgagaagaaagccgccgaagcagac	Protospacer
.*..************ *.*********. ..*

12. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MN693088 (Marine virus AFVG_25M204, complete genome) position: , mismatch: 10, identity: 0.706

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
agtagccgccgagaagaaagccgccgaagcagac	Protospacer
.*..************ *.*********. ..*

13. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NZ_CP029833 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence) position: , mismatch: 10, identity: 0.706

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
gcaggccgccgacaagctggccgccgagggcgga	Protospacer
*  ********* **** *********... ..*

14. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NZ_CP040096 (Pantoea sp. SO10 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.706

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
gcacgccgccgagcagcaggccgacgaacatgcc	Protospacer
*   ********* ********* **** * .

15. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MF140406 (Mycobacterium phage DarthP, complete genome) position: , mismatch: 10, identity: 0.706

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
cctggccgccgagtggcaggccgccgacgaggcc	Protospacer
  .********** .************ .**.

16. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NZ_CP013109 (Sinorhizobium americanum strain CFNEI 73 plasmid B, complete sequence) position: , mismatch: 11, identity: 0.676

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
tgcggccggcgagaagcaggctgccaagcccgcc	Protospacer
 ******* ************.***.*.   .

17. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NZ_CP024309 (Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3b, complete sequence) position: , mismatch: 11, identity: 0.676

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
tgcggccggcgagaagcaggctgccaagcccgcc	Protospacer
 ******* ************.***.*.   .

18. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NZ_CP013054 (Sinorhizobium americanum CCGM7 plasmid C, complete sequence) position: , mismatch: 11, identity: 0.676

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
tgcggccggcgagaagcaggctgccaagcccgcc	Protospacer
 ******* ************.***.*.   .

19. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MH271308 (Microbacterium phage Percival, complete genome) position: , mismatch: 11, identity: 0.676

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
cgtggccgccgagcagaaggccgccgaccccggc	Protospacer
 *.********** ** **********    ..

20. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MH271298 (Microbacterium phage Floof, complete genome) position: , mismatch: 11, identity: 0.676

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
cgtggccgccgagcagaaggccgccgaccccggc	Protospacer
 *.********** ** **********    ..

21. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MG812490 (Mycobacterium phage Holeinone, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

22. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MH001452 (Mycobacterium phage Kheth, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

23. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MH697584 (Mycobacterium phage FrenchFry, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

24. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MN813678 (Mycobacterium phage Lephleur, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

25. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to KT365402 (Mycobacterium phage Tres, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

26. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NC_043767 (Mycobacterium virus TA17a, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

27. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MN234225 (Mycobacterium phage Rhinoforte, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

28. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to KR997932 (Mycobacterium phage Godines, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

29. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MH590591 (Mycobacterium phage Sabella, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

30. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to JN618996 (Mycobacterium phage Arbiter, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

31. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to KX443696 (Mycobacterium phage Laurie, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

32. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to MH727546 (Mycobacterium phage Eaglehorse, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

33. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to KT880194 (Mycobacterium phage Glass, complete genome) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
acaggccgccgagcagctggccgccgatgccgtt	Protospacer
.  ********** *** ********* .  .

34. spacer 6.1|4258842|34|NZ_CP016431|CRISPRCasFinder matches to NZ_CP032678 (Pseudomonas sp. Leaf58 plasmid pBASL58, complete sequence) position: , mismatch: 12, identity: 0.647

ggcggccgccgagaagcaggccgccgaaaagaaa	CRISPR spacer
aatcgctgccgagcagcaggccgccgaactcgcc	Protospacer
... **.****** **************   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

923211 : 932562

uncultured_Caudovirales_phage(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033464441.1\|923211_924855_-	chaperonin GroEL	A0A219YK78	uncultured_virus	3.9e-169	59.5
WP_003808621.1\|924887_925175_-	co-chaperone GroES	A0A221S4A8	uncultured_virus	1.2e-20	52.1
WP_033464438.1\|925416_925743_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_033464436.1\|925834_926335_+	arsenate reductase ArsC	A0A2H4J8A6	uncultured_Caudovirales_phage	2.0e-28	45.8
WP_033464433.1\|926393_927581_+	MFS transporter	NA	NA	NA	NA
WP_068925083.1\|927612_928035_+	arsenate reductase (glutaredoxin)	A0A2H4J8T1	uncultured_Caudovirales_phage	2.0e-53	75.0
WP_068925085.1\|928027_928750_+	arsenical resistance protein ArsH	A0A2H4J5V6	uncultured_Caudovirales_phage	1.1e-88	69.5
WP_068925088.1\|928806_929436_-	hypothetical protein	NA	NA	NA	NA
WP_033464421.1\|929432_930101_-	hypothetical protein	NA	NA	NA	NA
WP_068925090.1\|930173_930809_-	hypothetical protein	NA	NA	NA	NA
WP_068925093.1\|930852_932562_-	FAD-dependent oxidoreductase	A0A2P0ZL82	Lactobacillus_phage	5.9e-27	28.4

DBSCAN-SWA_2

2218429 : 2226593

Moraxella_phage(28.57%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033467958.1\|2218429_2219017_+	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	2.1e-16	46.8
WP_003811007.1\|2219035_2219419_-	thioredoxin family protein	V9SJ74	Achromobacter_phage	8.1e-09	25.8
WP_033467955.1\|2219554_2220580_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_033467952.1\|2220783_2222076_-	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	2.2e-66	35.8
WP_033467949.1\|2222208_2223249_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	9.3e-92	51.3
WP_080699987.1\|2223401_2224049_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_033467943.1\|2224174_2224933_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.1e-68	51.2
WP_080699991.1\|2225001_2225691_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	4.2e-32	46.9
WP_033467937.1\|2225708_2226593_+	peptidoglycan DD-metalloendopeptidase family protein	A0A292GJG6	Xanthomonas_phage	3.5e-15	49.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP016431

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection