CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP016350	Vibrio natriegens strain CCUG 16373 chromosome 2, complete sequence	0 crisprs	csa3,cas3,DEDDh,RT	0	0	3	0
NZ_CP016349	Vibrio natriegens strain CCUG 16373 chromosome 1, complete sequence	4 crisprs	cas3,DinG,csa3,RT,cas5f,cas7f,cas6f,csx1,cas4,cas2,cas1,cas9,DEDDh	1	1	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016349_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016349_1

1069110-1069193

Unclear

Consensus_repeat	Method
GTGTTCCGCCGAGTAGGCGGCTAA	CRISPRCasFinder

1 spacers

cas6f,cas7f,cas5f

The CRISPR arrays of NZ_CP016349_1

>merge|NZ_CP016349|1|1069110-1069193|CRISPRCasFinder
GTGTTCCGCCGAGTAGGCGGCTAAAAATTTTGTCTGAGGAATTTCAAGCGGAATGGAACCGTGTTCCGCCGAGTAGGCGGTTAA

>NZ_CP016349|1|1|1069110-1069193|CRISPRCasFinder
GTGTTCCGCCGAGTAGGCGGCTAA	AAATTTTGTCTGAGGAATTTCAAGCGGAATGGAACC
GTGTTCCGCCGAGTAGGCGGTTAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016349.1\|WP_065299331.1\|1076157_1076844_-\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|239321
NZ_CP016349.1\|WP_065299324.1\|1064015_1065227_+\|TniQ-family-protein	unknown	unknown	gnl\|CDD\|377670
NZ_CP016349.1\|WP_065299319.1\|1060090_1060609_-\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP016349.1\|WP_065300428.1\|1076840_1077254_-\|disulfide-bond-formation-protein-B	unknown	unknown	gnl\|CDD\|179540
NZ_CP016349.1\|WP_065299322.1\|1062014_1062821_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP016349.1\|WP_065299329.1\|1073062_1073386_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299318.1\|1059230_1059812_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299327.1\|1068367_1068979_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	cas6f	pfam09618_cas6f_CAS-I-F	gnl\|CDD\|187870
NZ_CP016349.1\|WP_065299330.1\|1073419_1074334_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299332.1\|1077271_1077997_-\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
NZ_CP016349.1\|WP_065299326.1\|1067327_1068368_+\|type-I-F-CRISPR-associated-protein-Csy3	cas7f	cd09737_cas7f_CAS-I-F	gnl\|CDD\|187868
NZ_CP016349.1\|WP_081280047.1\|1061208_1061835_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP016349.1\|WP_065299323.1\|1062957_1063728_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP016349.1\|WP_065299320.1\|1060605_1061202_-\|sugar-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100047
NZ_CP016349.1\|WP_055467088.1\|1075121_1075454_+\|YnfA-family-protein	unknown	unknown	gnl\|CDD\|235016
NZ_CP016349.1\|WP_065299325.1\|1065230_1067321_+\|hypothetical-protein	cas5f	cd09736_cas5f_CAS-I-F	gnl\|CDD\|187867
NZ_CP016349.1\|WP_065299334.1\|1078930_1079707_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380379
NZ_CP016349.1\|WP_065299328.1\|1071300_1072719_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|350690
NZ_CP016349.1\|WP_065299333.1\|1078066_1078474_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|133412
NZ_CP016349.1\|WP_053394458.1\|1069561_1071304_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379114

Protein	Function_ID	Function_description	E-value
NZ_CP016349.1\|WP_065299331.1\|1076157_1076844_-\|thioredoxin-domain-containing-protein	gnl\|CDD\|239321	cd03023, DsbA_Com1_like, DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC motif, assumed to be imbedded in a DsbA-like structure. Its homology to DsbA suggests that the protein is a protein disulfide oxidoreductase. The role of such a protein in pathogenesis is unknown.	1.18991e-26
NZ_CP016349.1\|WP_065299324.1\|1064015_1065227_+\|TniQ-family-protein	gnl\|CDD\|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	4.80858e-13
NZ_CP016349.1\|WP_065299319.1\|1060090_1060609_-\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	2.58708e-33
NZ_CP016349.1\|WP_065300428.1\|1076840_1077254_-\|disulfide-bond-formation-protein-B	gnl\|CDD\|179540	PRK03113, PRK03113, putative disulfide oxidoreductase; Provisional.	2.25887e-23
NZ_CP016349.1\|WP_055467088.1\|1075121_1075454_+\|YnfA-family-protein	gnl\|CDD\|235016	PRK02237, PRK02237, YnfA family protein.	2.49126e-46
NZ_CP016349.1\|WP_065299322.1\|1062014_1062821_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	4.79062e-43
NZ_CP016349.1\|WP_065299327.1\|1068367_1068979_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	gnl\|CDD\|187870	cd09739, Cas6_I-F, CRISPR/Cas system-associated RAMP superfamily protein Cas6f. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6f is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-F subtype; Possesses RRM fold; also known as Csy4 family.	2.58574e-40
NZ_CP016349.1\|WP_065299333.1\|1078066_1078474_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|133412	cd04785, HTH_CadR-PbrR-like, Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators. Helix-turn-helix (HTH) CadR- and PbrR-like transcription regulators. CadR and PbrR regulate expression of the cadmium and lead resistance operons, respectively. These proteins are comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains have three conserved cysteines which comprise a putative metal binding site. Some members in this group have a histidine-rich C-terminal extension. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	6.62871e-53
NZ_CP016349.1\|WP_065299332.1\|1077271_1077997_-\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	2.95578e-41
NZ_CP016349.1\|WP_065299326.1\|1067327_1068368_+\|type-I-F-CRISPR-associated-protein-Csy3	gnl\|CDD\|187868	cd09737, Csy3_I-F, CRISPR/Cas system-associated RAMP superfamily protein Csy3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas7 ortholog.	1.22841e-128
NZ_CP016349.1\|WP_081280047.1\|1061208_1061835_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.53603e-29
NZ_CP016349.1\|WP_065299323.1\|1062957_1063728_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	7.71492e-67
NZ_CP016349.1\|WP_065299320.1\|1060605_1061202_-\|sugar-O-acetyltransferase	gnl\|CDD\|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	7.31184e-101
NZ_CP016349.1\|WP_065299325.1\|1065230_1067321_+\|hypothetical-protein	gnl\|CDD\|187867	cd09736, Csy2_I-F, CRISPR/Cas system-associated RAMP superfamily protein Csy2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas5 ortholog.	3.29652e-15
NZ_CP016349.1\|WP_065299334.1\|1078930_1079707_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|380379	cd06124, cupin_NimR-like_N, AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain. This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.29347e-27
NZ_CP016349.1\|WP_065299328.1\|1071300_1072719_+\|AAA-family-ATPase	gnl\|CDD\|350690	cd17932, DEXQc_UvrD, DEXQD-box helicase domain of UvrD. UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	2.74352e-13
NZ_CP016349.1\|WP_053394458.1\|1069561_1071304_+\|AAA-family-ATPase	gnl\|CDD\|379114	pfam13304, AAA_21, AAA domain, putative AbiEii toxin, Type IV TA system. Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.	1.79902e-19

>NZ_CP016349.1|WP_065299327.1|1068367_1068979_+|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4
MEPRYYFSIRFIPEHTDNELLAGRCVSNMHGFLSHERNRAFKNSLGVCFPRWSDKTVGNEIAFVSPHESILTGLSYQPYFSTMVNEGLFDISDIKIVPDDVEEVRFVFNKRIQKIFNGSKKRRIKRSMQRAEMQGRIYTPISTEEREFELFHEIPISSQSSGHAFVLHIQRQFPVYPEIGNSFNGYGFAANQRWRGTVPLVTF
>NZ_CP016349.1|WP_065299326.1|1067327_1068368_+|type-I-F-CRISPR-associated-protein-Csy3
MELCSQLNYVRSLSPGKAYFYYLDDNQRMCPLQIDRTHLRAPKSGYAEAYTGNFKAKNVAPQDLAFSNPQYIEECYVPPGVDDIYCAFSLRIRANSLFPEVCADAATRETLTGLAETYKELDGYKELAKRYAKNILIATWVWRNRECRNIEIEVKTEKKNWKIADARHLEWYGTWDRKSQSALDGLTDYLEKALSDRSDYFNMDIKAKLTVGWGDEVYPSQEFLDVKESGKPTKQLAKVVLNGEEESAAYHSQKVGAAIQLIDDWWDEEADKPLRVNEYGADKEYVIARRHSSLKRDFYSLISKTEDHIESMRKSNDISNDIHFIMAVLAKGGVFSGASKKSKKEE
>NZ_CP016349.1|WP_065299325.1|1065230_1067321_+|hypothetical-protein
MTTLQQLIEIDDDKLRFSELKKAFMPYTRPIEIDGNEKQALTILLNLSLGKPVAKDSLDISRAERYFADPENLAKAEQEIQWFHTHNLKFPDCRVAEQRILATPLPSETPTLTSQSLEQAYGWAHNSAVYKHTVWSLNTFLWRGKTENVLSLIRLGDEFWQALLAEFGFTPTGQFQFKTLVERQLPGTHFPEEVSRYSKQVRFPWRNDYLSVTPVVSHAMQQELAVLSRHRECSLRFKSMNYPNSASIGNLCGSLAGHINVLNYPVDVVPDSYQTLAASRERTSRYFDDYQLTSKRTCDVLAHLAGFEQLKSRKAQKHVRQYQLKIIRKQIARWLLPLIELRDNLVTEPLGINYEFDDQLAKQFLTIKEDDFLDWTTSLNQRLNLALQNNRFSSRFAYHPKLMRVLKTELIWVLTQLSRPEPGLPNISNDSVQYIYLSSMRAFDVAALSCPYLSGAPSMTAIWGFIHRYQKELEAQMSDEQCRISFNEFAFFIRHESVQTSAKLTEPSVLAKAREVSPVKRTTIIREDYADLVFDLVIRVESNQRISDYHDQLKAALPTNFAGGTLLQPEIDLNIPWLRTYTTKSELFQVVKGLPGYGTWLSPYSYQPQNLTELENTLAKDASLIPIVNGFHLLEKPINRKNGLTNRHAYAENNIALAKRVNPIEVRFGGRDHFFEQAFWSLDVTEQTILIKNLRN
>NZ_CP016349.1|WP_065299324.1|1064015_1065227_+|TniQ-family-protein
METDIQLYPDESLESFLLRLSQEQSYERFSHFAEDIWQNTLLQHEAISGAFPFELSRINIYKAQTTSQMRVRVLIDLEKQLGLTNFGVLRLALAHSKASFSPEYKAVHRFGVDYPQAFLRKRFAPVCSQCLEESPYIRQLWQFIPYQACHKHHCKLVHQCPECGNRLEYQHSELIEHCDCGFRLASCQAETANHASLTVAQWLAGEEVDKSGIFNQLLTQSSRFGFLLWYVNRYGDVDNISLEDFVRCCETWPQRLNEDLDAIVEKADMLRIQPWHKTYFCEVFSELLKECRHLPSREIGKNPVLQSVVQYFTELVTKYPRTKAANIADMLLSPLEASTLLSCSTDEILRLYQFGQLKAQFTPKLHGKIENHHSVFILRSIIELKLSRMCSETDGLMHYLPEW
>NZ_CP016349.1|WP_065299323.1|1062957_1063728_+|DeoR/GlpR-transcriptional-regulator
MEKFSPEERHQLILNLLESHNKVMATDLAVQLGTTEATIRRDLRFLANEGLCKRIHGGVLSLVPPTGTQEQRLENRNSEKQALALAALTIIKAEEVIFLDASSTHMLLASLLPNDIGLTVVTNSPAIATRLLERQHIRTILIGGELNYSVGGAIDITAVEALSKFRFDLCFMGICGWSSEAGFSAIHYQDGEFKRHAASKAGAIVALCTEDKIEALGPYPFMTSEDVDYLICSPNNTVAKDYFSQLDCTVITSNPF
>NZ_CP016349.1|WP_065299322.1|1062014_1062821_+|Cof-type-HAD-IIB-family-hydrolase
MIKLIISDMDGTFLNSHGDYNRELFQEVVTSMQEHGVKFAPCTGKQVERVEELFGEQSKDFWILGDSATRIKHQGEFIYQSLLNNTLGLSIIQQLESIEGSHIVIACTPEFAAIKRDTPEHLRTLVRRSYAEVKLVDSYEDIASDFVKITVYDENKQCPTIRPQLSHFDEQAYIVVSEAAWIDIANAGVHKGTTVEKLQSIVGATEAETMVFGDGFNDIELMERAHFSFAMRNAFEQTKAAANYITRSNDEDGVMHTILQFLALQKKS
>NZ_CP016349.1|WP_081280047.1|1061208_1061835_-|LacI-family-transcriptional-regulator
MESCAMVTMQDVAISAGVSKSSVSRVVNGLAVSPEITHKVTAAMEGLGYRPNALARALTTRKNSVIGVIISESLNTNPVVTEFLSQLLEIMSQLNKPLIVLRDQNEHFSRLKSFQALIEQRCEGIIHVSTGNNPYLDSSLFESRLCDDIPMIVIQSREEQASSCFQRHEKLLVSTTDYSIVNNSIRRQSLTIDESINYIISVFSIQTR
>NZ_CP016349.1|WP_065299320.1|1060605_1061202_-|sugar-O-acetyltransferase
MDEFKKMLAGEQYNPSDNNLSLMRARARKLIDKFNHSSFEEEESRLKLLKSLLGKAGDNISIHQNFYCDYGCNIYVGSNFFANYDCVILDCAEVHFGDNCLLGPQVGIYTATHPLDPIKRASGLESAKPIHIGNDCWIGGHATINPGVTLGNNAVVASGSVVTKSFGDNLVIGGNPARVIRELKCSLDTTPEDKDVKQ
>NZ_CP016349.1|WP_065299319.1|1060090_1060609_-|hypoxanthine-phosphoribosyltransferase
MKTNTYIGEVVLNEVQIQEGVKQVAQQLNQRFDDAVVITVVPGGILFTADLVRQLSFDISMDYISCPHTPGDKNNRSEIVYHQNINIMGRDVILIDDAIESGGTMKRLTEHLSNNFDIKSLSIATLFVKPSRVDIPVPQYFAYEMENDELLIGYGLPWKDKSRNLPFISKVI
>NZ_CP016349.1|WP_065299318.1|1059230_1059812_-|hypothetical-protein
MDAAVVAKRPLKTVGKWLGVTIASAVLLKFTDPLTDWIIDTIVSVSSRLSDSYMDGIYTKSANVYLESSVSIVIPLIFALVLLISATYAAARFSSKPEYNRTPFFMWLSANVCLVLVSASAVKYTSSNAIRSSTLSQLEIIKPYTDNTDELYSQFLLVQGKEDYIKVWSEIYTIAAKNDVVLPRFEVQGEQGE
>NZ_CP016349.1|WP_053394458.1|1069561_1071304_+|AAA-family-ATPase
MSVIRHIDIQNFRSIKNLSWNPKPGLNCLIGPGDSGKSTILDAIDLVLGARRSYSFNDADFYQLDTSSPLTITVTIGELDDELKNVERYGFFLRGFNFETKEIFDEPQPNCETVLTFKLYVDADLAPDWRLYSDRADADGLERRLPWKHRELLSPARLGTTSHQNLAWGHRSVLNKLSEDTLDVSSVLAQLGRQTREAFAAQPVQGVTEVLTQVQQIANGLGVPLGQLSALLDVNGISMSNGAISLHNSDGTPLRQLGTGSSRLLISGLQKATSSSSILIVDEAEYGLEPYRISRLLNELGSKDIEPQKQVFITTHSPYVLRELQAAQLHVLRKQSIAAQVFEFPLYSHHIYSLLGGEQQQATLRACAEAFFSKAIIVGEGSTEVGFIRGLDLYKQDNQQLGIQSKGGFCTDGGGGDNYFQRAKVFASLGYPVALLKDSDINSQAHQAQTEQCTQAGVTIFEWGHGMSTEGAIFSWCRVDILPLLVKVAADLNGHQEVDQHIKNKSNNQYDLAACLSNPLDEMRGSLALAAGHYKWFKNITKSETIIRNVVAPNMPLFNEHFQSILNGLLNWVEANGDIR
>NZ_CP016349.1|WP_065299328.1|1071300_1072719_+|AAA-family-ATPase
MNVETVLDTNRGAIVAPAGCGKTHIITETLSVNNTKSILVLTHTTAGVSALKKRLRKLSVPTSNYVITTIDGWALRIANSFPMTCPVHHSPEMPQLFYPEIRQTVLRLLNTGSISDILQSSYSRLLVDEYQDCDVNQHNLIASLSNILPTVIFGDPMQCIFNFGGPMPDWGSGVLKQFPLIGELNTPWRWNNAGAPLLGRWILETREALKQGTRVDLRTCPAHVILHQLTDVVRTDITNQHNAQHSILNHYPTDSLLVIGSSMDERSRHGYAQGNSRIEVVEPVQLASVTSAASQFDDNTGVALSASILQVASTMMTNVEMATTSKRVDSILNRRNRTPATTTEQALCNVAINSSRSNILAALQHLELKPGTRVYRKGAYNALKDSLALSITSPTISIFEAASAVRERLRQQGDQRIPNRAIGSTLLLKGLEADHCMILDAQARGMNANHLYVALSRGAKTITIFSRDVYIP
>NZ_CP016349.1|WP_065299329.1|1073062_1073386_+|hypothetical-protein
MNVNSFILSSLALSFLAGCAEPKPVVMKTATITVQNLTSDKISRIVFRQCGTSDDNLVFENIRVGQVVYMPLSVNCADFYAYDRNGKVIGKQLKVEMPPSLQWKITN
>NZ_CP016349.1|WP_065299330.1|1073419_1074334_+|hypothetical-protein
MKKRYLIVPSALLFLAGCSTTDFYQVQSQFRVNDAGEDPASVTRARGFDAEFNNIEVIAVKAPDRCISETETQSTGRATSASTVMKTECGVEMAQIERELAKAGYSVISWKILQNQMTASSTHLEAANSLGADALFQINSLERTTSAKGQDARWDRRYFKSDAKGIKGVPASVKEDTANRLNTIASYEEKVLVPSSDALSATINANVTLVKNARNIWFYDWSHQEAIAEDGVIEHYSLVRCSDETDYYVCLPYVAKVEQSSEEALVQGSSQGFSRTVNLEDQKRYKHDLLMKEVISDMVKNFSN
>NZ_CP016349.1|WP_055467088.1|1075121_1075454_+|YnfA-family-protein
MVEAKTIGLFFITAVAEILGCYLPYLWLKDGKSVWLLLPAALSLALFAWLLSLHPTAAGRVYAAYGGVYIFVAILWLWIVDGIRPTLWDIVGVTVALIGMAIIMFAPRHV
>NZ_CP016349.1|WP_065299331.1|1076157_1076844_-|thioredoxin-domain-containing-protein
MNRRVLIVVICLALIAAFGAAVLFKPQPQSSTASTEQPLATAQWAANQQALVRFHSPTFGPADAPVTIVEFFDPSCEACRAFYPIVKQILSEYQGQVRLVLRYTLFHQGSEKVSRILEAARLQNVYEPVLEAVLEVQPAWHDDPEVTSAWEAAEAAGLDLIKAREDMQSDRISAILEKDMQDVKTIGIQGTPTFFVNGRQLTEFGPKPLLNLVQESLPGSEPSRTVSE
>NZ_CP016349.1|WP_065300428.1|1076840_1077254_-|disulfide-bond-formation-protein-B
MPWTLLLAAWLLAAVSSLSAIYIGEVLGQAPCVLCWFQRAFMFPLAVILAIACYYSDLNVWRYALPLAVIGSLLALTHSLLYVGLLPQPIQPCTATGPSCSGAGMTIFGGLPLPFLSLGIFVAIIILLLEIRRRIRL
>NZ_CP016349.1|WP_065299332.1|1077271_1077997_-|cation-transporter
MDSCCENKAGELAQLRASQSRVLYIALAINAVMFVVEFGAGWIAGSTALLGDSLDMFGDASVYALTLFVLDRSQRARAGAALFKGGFMLLFGIVVVADAIRKVLIQEIPAADWMGAVGVLALLANGICFALLYRHRADDLNMRSTWLCSRNDLIANSSVIIAAGLVAVTNTLWPDIIVGLAIAALFLHSAWQVIREAWKEWRTSGAETAEQSSKGPIEASSDSCCSSSKRTCGSQSGEQSR
>NZ_CP016349.1|WP_065299333.1|1078066_1078474_+|helix-turn-helix-domain-containing-protein
MRKESYTIGQLAHDTGIKPVTIRYYEKMGLLPEAIRSASGYRMYSVTDHSRLVFIRRSRGLGFTLDDIRELLSLADRQQESCAGVDAKVDQQLEQVRSRLRDLRAMEVELERLSECCEGGVIMDCRIIETLSSEA
>NZ_CP016349.1|WP_065299334.1|1078930_1079707_+|AraC-family-transcriptional-regulator
MKFCDETLAPPILAYAHNYSHGDVEPPHTHQCAQFLHALNGVIRVDTQSESWVVTTNQGLWIPAGISHSLRITGDVRVRTLFVDPMARADLPNTCVLSKVSSLLTSLIVEAVSLPDIRIAGTREERIFELILDELRLLNPIDFYLPNPRTEALVMLCKNVSKRLSHPWTASDAAKYLGQSERTVSRRFQQELGLTFTEWLRQKRLLHASELLASGCSVLDTALAIGYDSPSAFSAMFKSRTGLSPREYCPMVNPLEQD

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Crispr_ID: NZ_CP016349_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016349_2

1285616-1286012

TypeII

Consensus_repeat	Method
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	PILER-CR
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	CRISPRCasFinder
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	CRT

5 spacers

cas4,cas2,cas1,cas9

The CRISPR arrays of NZ_CP016349_2

>merge|NZ_CP016349|2|1285616-1286012|PILER-CR,CRISPRCasFinder,CRT
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAACTTTGATGATGAAACCAGGTTCTATGTATATACGTGTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAACCGACTCAACACACTTGTCAGAAATCACTTGTTCGGCAAGTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAACTGGGGAGTCTTCGACTTTCTCGCTAGTAATTACTGGTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAACGTCCACACGCTGACAGCGCTCCGTATGATTACTGTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAACGCGTTGTCCTACGTTGCTCCTATCGCGTATGCGGCGTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC

>NZ_CP016349|2|1|1285616-1286012|PILER-CR
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	TTTGATGATGAAACCAGGTTCTATGTATATACGT
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	CGACTCAACACACTTGTCAGAAATCACTTGTTCGGCAA
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	TGGGGAGTCTTCGACTTTCTCGCTAGTAATTACTG
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	GTCCACACGCTGACAGCGCTCCGTATGATTACT
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	GCGTTGTCCTACGTTGCTCCTATCGCGTATGCGGC
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC

>NZ_CP016349|2|2|1285616-1286012|CRISPRCasFinder
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	TTTGATGATGAAACCAGGTTCTATGTATATACGT
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	CGACTCAACACACTTGTCAGAAATCACTTGTTCGGCAA
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	TGGGGAGTCTTCGACTTTCTCGCTAGTAATTACTG
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	GTCCACACGCTGACAGCGCTCCGTATGATTACT
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	GCGTTGTCCTACGTTGCTCCTATCGCGTATGCGGC
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC

>NZ_CP016349|2|1|1285616-1286012|CRT
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	TTTGATGATGAAACCAGGTTCTATGTATATACGT
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	CGACTCAACACACTTGTCAGAAATCACTTGTTCGGCAA
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	TGGGGAGTCTTCGACTTTCTCGCTAGTAATTACTG
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	GTCCACACGCTGACAGCGCTCCGTATGATTACT
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC	GCGTTGTCCTACGTTGCTCCTATCGCGTATGCGGC
GTTTCAGTGGCTGACTTGTTGAGATAAGCTGTGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016349.1\|WP_065299422.1\|1286699_1286987_-\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0128_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_CP016349.1\|WP_014231399.1\|1294502_1294709_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299415.1\|1278560_1279289_+\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|307807
NZ_CP016349.1\|WP_065299419.1\|1283207_1283441_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299423.1\|1286995_1287979_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NZ_CP016349.1\|WP_065299414.1\|1275396_1278561_+\|HsdR-family-type-I-site-specific-deoxyribonuclease	unknown	unknown	gnl\|CDD\|273028
NZ_CP016349.1\|WP_065299420.1\|1283537_1284302_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299421.1\|1286131_1286713_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NZ_CP016349.1\|WP_081280052.1\|1296873_1297500_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NZ_CP016349.1\|WP_065299424.1\|1288140_1292565_-\|hypothetical-protein	cas9	cd09704_cas9_CAS-II-B	gnl\|CDD\|274401
NZ_CP016349.1\|WP_065299416.1\|1281439_1282177_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299417.1\|1282257_1282863_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299418.1\|1282894_1283152_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299428.1\|1298741_1301132_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173799
NZ_CP016349.1\|WP_014231384.1\|1280868_1281207_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299427.1\|1295422_1296154_-\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|270349
NZ_CP016349.1\|WP_014231390.1\|1284434_1285448_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372340
NZ_CP016349.1\|WP_065299426.1\|1294895_1295240_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016349.1\|WP_065299413.1\|1273345_1275400_+\|DUF262-domain-containing-protein	unknown	unknown	gnl\|CDD\|377008
NZ_CP016349.1\|WP_065299425.1\|1293124_1294309_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP016349.1\|WP_065299422.1\|1286699_1286987_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.65226e-09
NZ_CP016349.1\|WP_081280052.1\|1296873_1297500_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	4.7185e-11
NZ_CP016349.1\|WP_065299415.1\|1278560_1279289_+\|M48-family-metallopeptidase	gnl\|CDD\|307807	pfam01863, DUF45, Protein of unknown function DUF45. This protein has no known function. Members are found in some archaebacteria, as well as Helicobacter pylori. The proteins are 190-240 amino acids long, with the C-terminus being the most conserved region, containing three conserved histidines. This motif is similar to that found in Zinc proteases, suggesting that this family may also be proteases.	2.14584e-67
NZ_CP016349.1\|WP_065299414.1\|1275396_1278561_+\|HsdR-family-type-I-site-specific-deoxyribonuclease	gnl\|CDD\|273028	TIGR00348, R_protein, type I site-specific deoxyribonuclease, HsdR family. This gene is part of the type I restriction and modification system which is composed of three polypeptides R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognize specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. They also catalyse the reactions of EC 2.1.1.72 and EC 2.1.1.73, with similar site specificity.(J. Mol. Biol. 271 (3), 342-348 (1997)). Members of this family are assumed to differ from each other in DNA site specificity. [DNA metabolism, Restriction/modification].	1.37708e-152
NZ_CP016349.1\|WP_065299423.1\|1286995_1287979_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	8.23863e-77
NZ_CP016349.1\|WP_065299424.1\|1288140_1292565_-\|hypothetical-protein	gnl\|CDD\|274401	TIGR03031, cas_csx12, CRISPR system subtype II-B RNA-guided endonuclease Cas9/Csx12. Members of this family of CRISPR-associated (cas) protein are found, so far, in CRISPR/cas loci in Wolinella succinogenes DSM 1740, Legionella pneumophila str. Paris, and Francisella tularensis, where the last probably is an example of a degenerate CRISPR locus, having neither repeats nor a functional Cas1. The characteristic repeat length is 37 base pairs and period is about 72. One region of this large protein shows sequence similarity to pfam01844, HNH endonuclease.	1.75744e-93
NZ_CP016349.1\|WP_065299427.1\|1295422_1296154_-\|prephenate-dehydratase	gnl\|CDD\|270349	cd13631, PBP2_Ct-PDT_like, Catalytic domain of prephenate dehydratase from Chlorobium tepidum and similar proteins, subgroup 2; the type 2 periplasmic binding protein fold. Prephenate dehydratase (PDT, EC:4.2.1.51) converts prephenate to phenylpyruvate through dehydration and decarboxylation reactions. PDT plays a key role in the biosynthesis of L-Phe in organisms that utilize the shikimate pathway. PDT is allosterically regulated by L-Phe and other amino acids. The catalytic PDT domain consists of two similar subdomains with a cleft in between, which hosts the highly conserved active site. In gram-postive bacteria and archaea, PDT is a monofunctional enzyme, consisting of a catalytic domain (PDT domain) and a regulatory domain (ACT) (aspartokinase, chorismate mustase domain). In gram-negative bacteria, PDT exists as fusion protein with chorismate mutase (CM), forming a bifunctional enzyme, P-protein (PheA). The CM in the P-protein catalyzes the pericycle isomerization of chorismate to prephenate that serves as a substrate for PDT. The CM and PDT are essentail enzymes for the biosynthesis of aromatic amino acids in microorganisms but are not found in humans. Thus, both CM and PDT can potentially serve as drug targets against microbial pathogens. The PDT domain has the same structural fold as the type 2 periplasmic binding proteins (PBP2), many of which are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	8.40942e-16
NZ_CP016349.1\|WP_014231390.1\|1284434_1285448_+\|hypothetical-protein	gnl\|CDD\|372340	pfam12835, Integrase_1, Integrase. This is a family of DNA-binding prophage integrases found in Proteobacteria.	6.96836e-05
NZ_CP016349.1\|WP_065299428.1\|1298741_1301132_+\|S8-family-serine-peptidase	gnl\|CDD\|173799	cd07473, Peptidases_S8_Subtilisin_like, Peptidase S8 family domain in Subtilisin-like proteins. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	4.72258e-120
NZ_CP016349.1\|WP_065299421.1\|1286131_1286713_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	2.83186e-24
NZ_CP016349.1\|WP_065299413.1\|1273345_1275400_+\|DUF262-domain-containing-protein	gnl\|CDD\|377008	pfam03235, DUF262, Protein of unknown function DUF262.	7.84102e-25

>NZ_CP016349.1|WP_014231390.1|1284434_1285448_+|hypothetical-protein
MRKRNYVGHLAKAPRDFNKPNFNLGSRDMVKALINASFENQGGMVTNTHRARLPALKHFISFIKTHTPVKRLNEIEKQHVVSFGEFLKNNADEELLSPATARDYLSHVNRALAQARGDEACVVNATRDLGFTPKSGIATLDGSVKEGLHEKVLPQVTPEVGFVMQLQRTFGVRFREGALLDASRVLEELHRGRAPMLLRGTKGGQSRPLPVDSEEKYRLLVRVAAFQQSLGQDSLIPSNLSFKAFQSDAWRQTKQADTSYLSHGERKHFACETYYQLMGVRCPVQSNVAHGKKHHQYIASELNISEEEAKQRDCDVRLTISKLLGHHRVSITNAYLG
>NZ_CP016349.1|WP_065299420.1|1283537_1284302_+|hypothetical-protein
MGQGVTLNRSVYLCLIVLILFGCKVEDLNSDYLCFNADNHYIDGSTGTSAVFRVDSGHGTQIGYSANGGLVLHSECAAALTIRDDVSTTYAWFEYGREVEYDSIQSLRFFTANQRINLHARRKIRPGIPTEEYSERSFDYNSRPQRTRTVFYGEFPYSEIDVRDHYNQGSIRQVSASIGSASKVYRWSNNTDQFDCLYTSHTDTAFDIGCQNEASLDQQYLGLRAPLEDYFQSLSQPFLYETEEAEIQRHIDRY
>NZ_CP016349.1|WP_065299419.1|1283207_1283441_+|hypothetical-protein
MTEEEKAEVKKLINEQNKAIDQRIESQERKLDALLSRAPWWHCFFNETLDVILATLCKGIILGILVFYLLINPIISG
>NZ_CP016349.1|WP_065299418.1|1282894_1283152_+|hypothetical-protein
MTTDRKETEVQPIKPGIEIMAITILTILTVIFLLANHISESTFQARCRGYEERIEKSLKQTMAGEDELHLIQTNFQQYKKDCSAH
>NZ_CP016349.1|WP_065299417.1|1282257_1282863_+|hypothetical-protein
MLLVLRIGLTLYCFLTVGSVSEWLAISLSGVLTVLISLFIIVPSFKLPFWRTLQQLTCSRLVLTGISAFVIATFVYGQLTLLVELNQPLLKGLHRPDFTGYWAAARAYDTFFVWVGLFLVLTILLEEWRVLFSRPPTFNCYYLQGVSVTLAFAVVACGEYLGSATQAWLSAVVSYVVIVLFHIGGFRFEQKQPKRNTRWLV
>NZ_CP016349.1|WP_065299416.1|1281439_1282177_+|hypothetical-protein
MTMFISRTINFFNLMKRLGLVLLLFVLGACLLTLSTYLVSASGQWGWLAFGILVGTLPFLGFYLAGFLLAPKRFYQTKMWKNQSSSLRWGVVIVCAVSSYLSMGELNSVADLSVVEQPMPLLEQLLITVGAVILLTGVYMPLRAIILFRCLGMGRTNAIGEVFDEHNKDTYSSLAIPPLPMSIMMLVMMCYSLTALSTSNAPEGANYLLFFLLEITAALDIAYVYRNRTKGGPHFHLKDPLAPQA
>NZ_CP016349.1|WP_014231384.1|1280868_1281207_+|hypothetical-protein
MPKRAGEFLVKFFGVTMNRDTKKQILTVMAPYHKRGIPFRRKQIKRLIAILDDIFIHEPYLGERLQKVGKRQIIGYWQRTRCETAQVRAEKYAILKLFFETAQLTGRVPRPK
>NZ_CP016349.1|WP_065299415.1|1278560_1279289_+|M48-family-metallopeptidase
MATTDSFEVTIAGIELTVNRKAITNIHLSVLPPNGAVRLSVPVETSDQAIRLAVINKLAWIKQQQADFASQRRQSVREMISGESHYLWGQRYLLRVVEAPGKHHVAVKSNRIELGVASKTTTENRLKLLNEFYRSEIKATLSNLLPLWQEKLGVEANALGIKKMKTKWGSCNSSDKRIWLNLELAKKPPECLEFILVHELTHLLERHHNDRFRALMDEHLPDWRERRRLLNSLPLAYEDWSY
>NZ_CP016349.1|WP_065299414.1|1275396_1278561_+|HsdR-family-type-I-site-specific-deoxyribonuclease
MSRVGQKERVTQTRLRRFFVDQLDYDYLGDWEYREGNRNIETALLTDWLAERGVSEALIKRTLRKLDVAAALGEGKKLYDANKEVYRLLRYGVKEKEGTGQQNQTVWLIDWKNPEANHFAIAEEVTIQGEKKKRPDIVIYVNGIALGVIELKRSSVSVSEGIRQNLDNQKKDFIRNFFTTMQLVMAGNDTQGLRYGTIETSEKYYLEWKEQPSAHQLLNATVKTETLLDEHTAQLCEKKRFLQLLHDFIVFDAGIKKTCRHNQFFGIQAAKKHITSRQGGIIWHTQGSGKSLTMVWLAKWIRENVTDSRVLVITDRTELDEQIEKVFTGVDEDIYRTKSGSDLVATLNQPNPWLMCSLVHKFGRNGEEPTESEKNETTDEFLKDLKGALPDDFSAKGNLFVLVDECHRTQSGKLHEAMKAILPEAMFIGFTGTPLMKKDKKKSLEVFGPYIHTYKFDEAVSDGVVLDLRYEARDIDQHLTSSKGVDTWFDTNTQGLSNLAKIQLKEKWGTMQKVLSSKSRLERIVMDIWLDMKRKPALLSGRGNAMLVCASVHQACVVFDLFSKTDLAGKCAIVTSYQPTASSSKGEESGEGQTEKLFKYETYRKMLADYFEQSEEEAAKRVEEFELKVKERFIKEPGQMRLLIVVDKLLTGFDAPSATYLYIDKKMADHNLFQAICRVNRLDGDDKEYGYIVDYKDLFRSLDKAIKDYTAEAFDGYDDEDVAGLLKDRLKEARADLDNALEVARALCEPVKAPRDTQAFMHYFVGESGAESTNEDERGEKEALRLTLYQAVAKLIRSYTNLANEMAQAGYTAKEAQSIKQEVAYFEKVRDEVKLSSGDLLEMKRFEPAMRQLLDMYIRADDSETLMDFEEYGLIDLVVNNGGKGLDSLPEDIRKNEEAMAEAIENNVRKTIVDENPVNPKYFESMATLLDELIKQRREQVISYQEYLEQIRALAKKVVNPTSNTAHNYPDSVDTLAKQALYDNFGNDEVLTTQVDTAVRLNKEADWLGDTFKERKIENAILEATNDFGMDDDDAIDEQLDRMMDIIKAQREYH
>NZ_CP016349.1|WP_065299413.1|1273345_1275400_+|DUF262-domain-containing-protein
MNNGLGAKAHDGIHSFRVKELLADTSRYLVPMYQRNYAWGEGEINQLIQDVQDYQQHKPNQPYYIGTLVVFERPDGQFEVIDGQQRFTTLTLLAFALKRIAEGNISMESKRTAPQSIDMSWYDAPNLDFESRPKSSDTFSALKQGVALENLINDEFNLDVVEGYHLLEKGLLALVDKLDDFCSYLFNQVEIARVSVPKDTDLNHYFEVMNNRGEQLEKHEVVKARLMSVLNNIEDKTEREQSIDVLAKVWDATANMERYIQYGFSKPVRHELFGTNDWGQFTPQSFEDVQSIIASGEQQTDNSLSADSISLCDMLANPPPTKSRGDTELTPERFNSVINFSNFLLHVLRVSTKQDVALDDKRLLEQFEQYLLKKDLLDNEARIEAVKAFVFALLKAKYLFDQYIIKREFAQGEDKWSLKRLHFYNDKSQSYINTFDSSAKNDSEDGFEGINRRILMLLSALHVSTPTLVYKHWLNGALYQLYYMDEISPVAYLERLEHLARQFVFGRFLQPEGAEYFAMIYQGEGYRALDSDDESVMDLLRYGAIENNLVFNYLDYLLWCNGIESSTDAVINQFEFTFRSSVEHFYPQHPLDGHKKLDNSELHRFGNLCLISHSKNSKLSNVQPSAKRDHFKAAINDKNIDTLKLYEMIQHLNSSGEWGVKQILEHEQQMIEVLKKDSRTGANG
>NZ_CP016349.1|WP_065299421.1|1286131_1286713_-|CRISPR-associated-protein-Cas4
MEYSDDLIPISHIRQHLFCPRVPWFKHVMQFEPPEQGWVTQGKRWHEAHHPRHKRRLCSYLAPPTERTLDVYVVSTRLKIHGYVDELITNGQQSVVMEYKVDSGKPTLAQKLQLMAYVMALEESTNQKVVAAILLKGDATKQYKVQLNDELKHILLDVLYKLRKTIASHRMPNSSASSAQCDQCEYLRYCNDR
>NZ_CP016349.1|WP_065299422.1|1286699_1286987_-|CRISPR-associated-endonuclease-Cas2
MAKTTEVIISYDIEDNKTRTRLFNQLKDVGMISIQKSVMWGRLLPADIKLAKRILSSEIESDTDKAFILVSKLSENAQFYGLAPDFEEYDGHGIF
>NZ_CP016349.1|WP_065299423.1|1286995_1287979_-|CRISPR-associated-endonuclease-Cas1
MQHIVIREYGKSLGVTSERLVVKEGNFPTKEIPLRKISTLSIQKSGVSLSSNLLAACAKYGIKVFIGNRAQELCCLQGNAQHAVVQNRIHQFRFLEEDEQRYRIARAFIYGKIRNQRSTILYFHKQKCSSVKKAAAARLSDELGQLSVQVRDLPYSANWNAVLMGLEGRAAASYWQVLGEHQWLGPTFHTRIGRGAQDPANQALNYGYGILSSVVWNALTNAGLEVYLGALHAVRPGKPALVLDVMEEYRAWVVDRAVIKLRSELKGDELKPKTRKKLTADILSTLAKPIPYKGKKIRLESVIQRQCYRLCGLFADERKYRPLLFRW
>NZ_CP016349.1|WP_065299424.1|1288140_1292565_-|hypothetical-protein
MYAASYPAGTTLKDFSTDMVSKIAFAATSYAPDKGGYVLLQNGRTANRHMSRNRTRNRQAKKLFKTMLECLVGFDVEKHKEAIAHFLNRRGYSYVERQVSLEDLAALTTEQLLPLMRELTKLGHKGIVEEFELTDPIEALRCVASQGAFQLEALIEAFKKLPVKQSKPMLALRDSAKLYLKDQTDGALHRSEYFENLAHDFNKLRKHPERHCRRFFHALNDLKQAKHGYQKDDVLRLLCHVSNFDLKLLNRILRALPESPTETLLNAVLTEHVSKWILKQWVLSESNGQARLQEIRELRRALKQHLTLKPNEIVSFLLNTPPEQTIPPYESHTNRRPPSCQTLILNPKCLDDAYKDWRNWLSELIQASPRKSEIYSYREQLAALISNQEQPLITTEELDARTLQLILDTSKAIDPFKLNCIWSHLKKCHKQARSGQDTSSVIHKLEEALKSSVLPEAFKQVDMAEALQGSFWHLVNRYYQARRKCRDGRYFIPIDKTQKSRHKRWQNDGKLLAMCRHRPKQIKHQALQDVRVLLGLNQQQLPKKVVLNQNGEVDLGAYLLQVKGLKKACDDARKAQKQWGAELNDNLTTDNTLIELTAKIQVLLPALSQHLQLDDSSSAAFIERNQSIYQFAQLYQLTWGDRSGFASTCPVCATDNAVRMADNSAKAQAARLSTLSMHLIDGGLKRHLNHQAHHIANRIWDKLLKPALLKGDKVTMPLILEQNRFDFAENLHMLKGTLKPKGSSAPDQFQPKVERIKQASHVFCPYDKQVTSLGDDGDVDHIIPRSGRYGTLNDEANLIYASRNGNRKIKGNRELTLSDLSDAYLEHQFATTDRAAIQHTIEQRLTGEREEIFRFGRYRQFRALTPENQVAFRHALFLPADHPLRTLVISTLQHRSKSRVNGTQRFMAQLLADIFWQKAKELGKQGNLAFDYFEVSSDPNNEASTVALRRHLESSTLASGFDLQPFAKQTYQPQQAYSHVIDATLAFMLSVQAHPNEGAMRIHLAKGETIWSQVDEDGVYLNTAFEQVVVLPEQLSPVVEVKPRPTHTKVKQLLDGAKPHQVFNRRIFNQNALGLEFYDFQVISGQLFRGWVVVDNGQAEFVKHSGDKSKPADKNLDKIQRLVELGLFRLQRIQGLPIYRANKQALLGYIFDALSQAKVAPQPKQEQSQLVSWLLGKGAGNLYYYTSSKELTKAPSVLKSKGASPFKQHWLNFYTGWEYRAQHPVKQSNGVLEIASDEQANWQAYCETFLKWTPIQETNEVFQPAHAASRAFTMRAPGTPSGVPSLIRKLSAEGSKSYNVMDIDNGVLGKEQAPALALASPNVVLFDRNVLQNGYMADTSPKQVLEATEIPVRAALNTENCNNAGLDLESIKVVIEANKLHIKNIERQWFETNLLLENEVAEKPWQEKLRIFCSGQTKAYGDHAVAEDSFKKLLKRSAKHDKGMALKVEDDKVSVTLVLDKKVTQKILEEITQN
>NZ_CP016349.1|WP_065299425.1|1293124_1294309_+|hypothetical-protein
MSNGPIIVSPASSVQRLQRVELHATGIYDEKWLQQLIFANADLLPFYEIDADYTGAVPVCMELATKSGRVDCIYVTPSGRLVIAETKLYRNPQSRREVIGQILDYAKDLMNWSYDELDTKVCAINGGLSLFELVKADGHEVLEASFIDTVQRNLSKGRFLLLVVGDGIREGAFEIKDFLNTYASMEFSFAMVEVQIFHMPGEQLLVNPQVMRKTEITERRVISINQVSSEVTEKLESTNEQNESATNKGSGQSYEYWSALLDYLELEDTSVRLPTPSTQGHLWFELPPRAHNSWITTYRSKPNEVGVFVKFRNDALGQYLFEYLSERRESLMPLLPEGAEFVPDKLKISIPAITLDWQNEESWKEAFDFYQLRLNQIYPVVKPLLLQALNAYEN
>NZ_CP016349.1|WP_014231399.1|1294502_1294709_-|hypothetical-protein
MKKVFWKIVFSLMSLGSVAAVIAPNAPKVFYWLGWLYIILMLGVGVLTFYAARIIAWCDKKLEINKDE
>NZ_CP016349.1|WP_065299426.1|1294895_1295240_+|hypothetical-protein
MKKVNIGLTLAVVTVILTFIGSTNKTFIGHWGQGVLVMIWVYYPPLILVGIFHIFSHRKVIYSFKNNLWVMGALANILLLISPLSLLRDDIGVGWLLLFTVTVIDMVILFTKKK
>NZ_CP016349.1|WP_065299427.1|1295422_1296154_-|prephenate-dehydratase
MLKPLGIAIAASTLMFSTLTTASESVFAQASRGSFNDAAITKLFEQQPSLSASVTFSGTPSNTFKQSIDHGALAFSAVENSTIDGRLVQATVEAFQQYRLLSVKAFIQTPIEMCVLMNQQDVANDTAITMIASHPAALKQINAWKAGIQPKELEIPEGTAAAAKLVADRDLPTGTAAIGACVLDTVYTNLKVVEKGVQDNKNNKTSFLLMKVEPREQTISEAEARKELTAAIEMGKKLAKVSQ
>NZ_CP016349.1|WP_081280052.1|1296873_1297500_+|methyltransferase-domain-containing-protein
MVAWFMSVNISDYDKNAVELAKQYDSLSFESVHRSWKQYWPEKGANVLDVGAGSGRDAQWFSDQGCFVVAVEPASNLRQLAISNSSAQIVWVGESLPDLTRVSELPYQYDLILLSAVWMHLTTKQRAEAMRVLSLLLSDRGNLVITLRHGSFDDGRETYGVSVAEIENMGRKLGLSVCHVVDGEDALNRPEVKWQSVILENIKTLEGK
>NZ_CP016349.1|WP_065299428.1|1298741_1301132_+|S8-family-serine-peptidase
MFTSTFVKTIRAQTKKLWCVLFLALTSIPIHAASPSARAELENNPSLAYSSESVLIRFKPEASAANKQQARQLVNGKTMRQFAIVNALEHLQLGPGRSVEKAIETLQRLPFVDFVEPDYVIRAYMVPDDYYYTEGLQWAPDNDGSFYLNLWGPFLGTLFPIKAGADIDANLAWDITTGSSDVIVAVIDTGVDYNHEDLAGNMWSNTGSSSGVHGYDFYNDDNNPMDEHGHGTHVAGTICAQGNNQVGVAGVAWQCQIMALRFLGADGSGYTSDAISAIEYAVENGAKISNNSWGGEPEFSDGLYTAIQSAAKSGHLFIAAAGNGGSDGVGDNNDSTADYPSSFDLNNIISVASTNAADDLSSFSNYGSNRVDLGAPGEDIVSTYTIAGDYEIASGTSMAAPHVAGVAVLVASMHPEWGYADIKNRILSTTRPLTSLAGKTVTGGVLNALDAVQEPATLPTAPTSLSATAVSDTEIMLTWEDNSNNEQGFRIERNSGSGWEVDFASVGANVTTYSDTGLTAENSYDYQVVAYNEVGDSAYTDVAPATTQSTPSDTVQTTVASSEIFGAGTVTGTYVDTAEANDGNVQTIVERLSGGKPANRYYYLQHTWVFTNVPIGTSTLYLKASASSASSNVELFDFSFSLDGSLYTSIPNTQDGESPVIYRAEFTLPESSDGTVYIRVTDNNSEASDTVADEISVDQLVIETQVDDSTPVDAFGLTAYPNTAKSGWHDVILSWTASTSVDVLRSEGTGEMGMIATGVSGGTYTDARISKGSATYTYKVCEAGTNNCSSEVVVIF

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Crispr_ID: NZ_CP016349_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016349_3

2993950-2994206

Orphan

Consensus_repeat	Method
GTGCCTCCTTAGCTCAGTAGGTAGAGCAACGGACTGATAATCCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP016349_3

>merge|NZ_CP016349|3|2993950-2994206|PILER-CR
GTGCCGACTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGGTCACCAGTTCGATTCCGGTAGTCGGCACCATTCTTTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTGTCGGTGGTTCGATTCCGCCTCGAGGCACCATTATTTGGTGCACTTGCTTAATTTAATTGATTAGCAAGACACAAACAGAATAGTTCCTCCTTAGCTCAGTTGGTAGAGCGACGGACTGTTAATCCG

>NZ_CP016349|3|2|2993950-2994206|PILER-CR
GTGCCGACTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAG	TAGGTCACCAGTTCGATTCCGGTAGTCGGCACCATTCTT
TTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCT	CGTGTCGGTGGTTCGATTCCGCCTCGAGGCACCATTATTTGGTGCACTTGCTTAATTTAATTGATTAGCAAGACACAAACAGAATA
GTTCCTCCTTAGCTCAGTTGGTAGAGCGACGGACTGTTAATCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016349.1\|WP_065300230.1\|3006645_3007584_-\|bile-acid:sodium-symporter-family-protein	unknown	unknown	gnl\|CDD\|223462
NZ_CP016349.1\|WP_014233036.1\|2984964_2985255_+\|YggU-family-protein	unknown	unknown	gnl\|CDD\|179931
NZ_CP016349.1\|WP_065300478.1\|2986514_2987690_+\|radical-SAM-family-heme-chaperone-HemW	unknown	unknown	gnl\|CDD\|235550
NZ_CP016349.1\|WP_020334002.1\|2985329_2985761_+\|DUF4426-domain-containing-protein	unknown	unknown	gnl\|CDD\|379616
NZ_CP016349.1\|WP_020334476.1\|3013785_3015294_+\|leucyl-aminopeptidase	unknown	unknown	gnl\|CDD\|234863
NZ_CP016349.1\|WP_065300231.1\|3008594_3009260_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187643
NZ_CP016349.1\|WP_065300226.1\|2990741_2991818_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|182805
NZ_CP016349.1\|WP_020334475.1\|3012484_3013585_-\|LPS-export-ABC-transporter-permease-LptF	unknown	unknown	gnl\|CDD\|185075
NZ_CP016349.1\|WP_065300229.1\|3004276_3005530_-\|HD-GYP-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP016349.1\|WP_065300227.1\|2992202_2993345_+\|membrane-bound-lytic-murein-transglycosylase-MltC	unknown	unknown	gnl\|CDD\|183271
NZ_CP016349.1\|WP_065300224.1\|2985894_2986497_+\|XTP/dITP-diphosphatase	unknown	unknown	gnl\|CDD\|234648
NZ_CP016349.1\|WP_065300232.1\|3009438_3010707_+\|DUF2254-domain-containing-protein	unknown	unknown	gnl\|CDD\|378351
NZ_CP016349.1\|WP_014233039.1\|2987769_2988690_-\|glutaminase-B	unknown	unknown	gnl\|CDD\|234880
NZ_CP016349.1\|WP_014233043.1\|2991837_2992110_+\|oxidative-damage-protection-protein	unknown	unknown	gnl\|CDD\|180059
NZ_CP016349.1\|WP_014233051.1\|3010900_3011380_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP016349.1\|WP_065300225.1\|2988778_2989807_-\|DNA-methylase	unknown	unknown	gnl\|CDD\|223971
NZ_CP016349.1\|WP_065300228.1\|2994505_2996131_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NZ_CP016349.1\|WP_014233047.1\|3005831_3006506_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP016349.1\|WP_014233041.1\|2989818_2990538_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP016349.1\|WP_014233052.1\|3011410_3012481_-\|LPS-export-ABC-transporter-permease-LptG	unknown	unknown	gnl\|CDD\|237900

Protein	Function_ID	Function_description	E-value
NZ_CP016349.1\|WP_065300230.1\|3006645_3007584_-\|bile-acid:sodium-symporter-family-protein	gnl\|CDD\|223462	COG0385, COG0385, Predicted Na+-dependent transporter [General function prediction only].	2.65185e-83
NZ_CP016349.1\|WP_014233036.1\|2984964_2985255_+\|YggU-family-protein	gnl\|CDD\|179931	PRK05090, PRK05090, hypothetical protein; Validated.	6.66239e-61
NZ_CP016349.1\|WP_065300478.1\|2986514_2987690_+\|radical-SAM-family-heme-chaperone-HemW	gnl\|CDD\|235550	PRK05660, PRK05660, radical SAM family heme chaperone HemW.	0
NZ_CP016349.1\|WP_020334002.1\|2985329_2985761_+\|DUF4426-domain-containing-protein	gnl\|CDD\|379616	pfam14467, DUF4426, Domain of unknown function (DUF4426). Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.	3.41423e-65
NZ_CP016349.1\|WP_020334476.1\|3013785_3015294_+\|leucyl-aminopeptidase	gnl\|CDD\|234863	PRK00913, PRK00913, multifunctional aminopeptidase A; Provisional.	0
NZ_CP016349.1\|WP_065300231.1\|3008594_3009260_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187643	cd08939, KDSR-like_SDR_c, 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR. These proteins include members identified as KDSR, ribitol type dehydrogenase, and others. The group shows strong conservation of the active site tetrad and glycine rich NAD-binding motif of the classical SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.64531e-69
NZ_CP016349.1\|WP_065300226.1\|2990741_2991818_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|182805	PRK10880, PRK10880, adenine DNA glycosylase.	0
NZ_CP016349.1\|WP_020334475.1\|3012484_3013585_-\|LPS-export-ABC-transporter-permease-LptF	gnl\|CDD\|185075	PRK15120, PRK15120, lipopolysaccharide ABC transporter permease LptF; Provisional.	2.71332e-132
NZ_CP016349.1\|WP_065300229.1\|3004276_3005530_-\|HD-GYP-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	1.07828e-67
NZ_CP016349.1\|WP_065300227.1\|2992202_2993345_+\|membrane-bound-lytic-murein-transglycosylase-MltC	gnl\|CDD\|183271	PRK11671, mltC, membrane-bound lytic murein transglycosylase MltC.	6.38057e-147
NZ_CP016349.1\|WP_065300224.1\|2985894_2986497_+\|XTP/dITP-diphosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	4.63161e-124
NZ_CP016349.1\|WP_065300232.1\|3009438_3010707_+\|DUF2254-domain-containing-protein	gnl\|CDD\|378351	pfam10011, DUF2254, Predicted membrane protein (DUF2254). Members of this family of bacterial proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.	5.17961e-119
NZ_CP016349.1\|WP_014233039.1\|2987769_2988690_-\|glutaminase-B	gnl\|CDD\|234880	PRK00971, PRK00971, glutaminase; Provisional.	0
NZ_CP016349.1\|WP_014233043.1\|2991837_2992110_+\|oxidative-damage-protection-protein	gnl\|CDD\|180059	PRK05408, PRK05408, oxidative damage protection protein; Provisional.	3.33891e-59
NZ_CP016349.1\|WP_014233051.1\|3010900_3011380_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.51369e-15
NZ_CP016349.1\|WP_065300225.1\|2988778_2989807_-\|DNA-methylase	gnl\|CDD\|223971	COG1041, COG1041, Predicted DNA modification methylase [DNA replication, recombination, and repair].	1.57202e-08
NZ_CP016349.1\|WP_065300228.1\|2994505_2996131_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	6.7791e-59
NZ_CP016349.1\|WP_014233047.1\|3005831_3006506_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.14472e-59
NZ_CP016349.1\|WP_014233041.1\|2989818_2990538_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	4.68784e-109
NZ_CP016349.1\|WP_014233052.1\|3011410_3012481_-\|LPS-export-ABC-transporter-permease-LptG	gnl\|CDD\|237900	PRK15071, PRK15071, lipopolysaccharide ABC transporter permease; Provisional.	0

>NZ_CP016349.1|WP_065300227.1|2992202_2993345_+|membrane-bound-lytic-murein-transglycosylase-MltC
MKKIVFIVAALLLTAGCSREVVEKFYDVEYEPTNRFANNLAELPGQFEKDTAALDSLINSFSGNIQKKWGKREVKLAGKSNYVKYIDNYLSRAEVDFQKGVITIETVSPTEPQKHLKNAIITTLLTPDDPAHVDLFSSKDIKLEGQPFLYKQVVDQDNKPIQWSWRANRFADYLISHEIKTKDVDFKKAYYVEIPMVEDHFIQRSYQYANIVRQAAEKYDIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFALVKNRSGQPSPEYLFNPENNIDTGTAYFYILKNRYLKEVSHPTSLEYSMISAYNGGTGGVLNTFNRSDRKRAMRDLNSLQPNQVYWALTKKHPNAEARRYLEKVTNFKKEFNSVQTF
>NZ_CP016349.1|WP_014233043.1|2991837_2992110_+|oxidative-damage-protection-protein
MSRTVFCARLKKEGEGLDFQLYPGELGKRIFDNISKEAWAEWQHKQTMLINEKKLNMMDPEHRKLIETEMVNFLFEGKDVHIDGYTPPSE
>NZ_CP016349.1|WP_065300226.1|2990741_2991818_+|A/G-specific-adenine-glycosylase
MTPFASAILEWYDAYGRKDLPWQQNKTAYSVWLSEIMLQQTQVTTVIPYYQRFLERFPTVVDLANAEQDEVLHLWTGLGYYARARNLHKAAKEVAQTYNGEFPLDIEQMNALPGIGRSTAAAVLSSVHKQPHAILDGNVKRTLSRCFAVEGWPGQKKVENQLWEIAEAHTPQTDVDKYNQAMMDMGAMVCTRSKPKCTLCPVADLCVAKKQGNILDYPGKKPKKDKPVKQTRFVMLHHKNANGHEVWLEQRPQTGIWGGLFCFPQTEHVDVESDIDLLLEQRGIQANDIKEQQTLITFRHTFSHYHLDITPILIDLSKQPDVIMEGNKGLWYNLSKPEEVGLAAPVKLLLETLPHELR
>NZ_CP016349.1|WP_014233041.1|2989818_2990538_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSEVTTNEYNEDGKLIRKIRSFVRREGRLTKGQESAMNECWPTMGIDYKAELLDWKEVFGNDNPVVLEIGFGMGASLVEMAKNAPEKNFIGIEVHSPGVGACLADAREAGLTNLRVMCHDAVEVFEHMIPNDSLATLQLFFPDPWHKKRHHKRRIVQLEFAEMVRQKLIPNEGIFHMATDWENYAEHMIEIMNQAPGFENIAEEGDFVPRPEERPLTKFEARGHRLGHGVWDIKFKRTA
>NZ_CP016349.1|WP_065300225.1|2988778_2989807_-|DNA-methylase
MYHYAILANPGHNRIYFDSAMTIACSELKAMLASEGVEVTEIGSKDVGLPAALVFSCAEALNEAQARKIAASSIYYALFEVREDGLLRPIQAPAFNTFPESMSQILRYTGKTNEQFTRLMVNLGVSAANTDSAQLTLMDPMCGKGTTLFEGLIHGLNVVGVEINQKWVQEIQTFVVKFMKNGRFKHKVSKEKRTSGGKKVADGFVVEAAATKEDYNQGNLQTMKLYSADTRIADQVVKKNSVDVMVSDLPYGVQHGSKNAKDSKLNRSPLELLKEALPAWKVVLKKQGSVVLSFNEFTLKWKDVAALFEEQGWKVLSEDPYIGYLHRVDQSINRNIIVAVKP
>NZ_CP016349.1|WP_014233039.1|2987769_2988690_-|glutaminase-B
MKPTVEILTDILTEVRPLIGQGKVADYIPALAKVPSNKLGIAVYTNDGEVIKAGDADEPFSIQSISKALSLTLAMCLYKQEEIWARVGKEPSGQAFNSLIQLEMEQGIPRNPFINAGAIVVADLLQSRLSAPRQRLLEFVRQLSGDTHIVYDKVVAASEMMHGDRNAAIAYLMRSFGNFENEVIPVLQNYFHACALKMSCVDLAKTFSYLANKGTSVHTGKPIVSPTQTKQLNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVPGDMTIAVWSPELDPAGNSLAGTKALELLSERIGRSIF
>NZ_CP016349.1|WP_065300478.1|2986514_2987690_+|radical-SAM-family-heme-chaperone-HemW
MLTPPALSLYVHIPWCVQKCPYCDFNSHELKAEIPEEQYINALLEDLDTDIEKYRLNDAPRPLHSIFIGGGTPSLISAQGIERLLKGIEERIPFKTDIEITMEANPGTIEAERFAGYRKAGVTRISIGVQSFEQEKLERLGRIHGKDEAVNAANLAHQIGLNSFNLDLMHGLPDQSIEQALADLDKAIELAPPHLSWYQLTIEPNTMFYYKPPTLPDDDDLWDIFELGHKKLAAAGYVQYEISGYSKPGFQCQHNLNYWRFGDYLGIGCGSHGKLSFADGRIIRTTKVKHPRGYLAAYQNMVKPHLHTEQFVEDEDRPFEFFMNRFRLMEACPKQDFIDTTGLPLSSIQDTINWALELGYLSETETHWQITEKGKLFLNDLLEAFMAEEDE
>NZ_CP016349.1|WP_065300224.1|2985894_2986497_+|XTP/dITP-diphosphatase
MKKIVLATGNQGKVREMADLLSDFGFEVLAQSEFNVSEVAETGTTFIENAIIKARHAAQETGLPAIADDSGLEVDYLNGAPGIYSARYAGEGATDQENLEKLLKAMEGVPEAERTARFHCVLVLMRHKDDPTPVVCHGKWEGRILTEAHGENGFGYDPVFFVPEDDCASAELEPARKKQLSHRGKALKSLFAQLSEQAAQ
>NZ_CP016349.1|WP_020334002.1|2985329_2985761_+|DUF4426-domain-containing-protein
MNKWITALLISLLSFPTFAEQFKNMKDIEVHYVAFNSTFLTPKIARSYDIKRNGYLAIINISVLDRASLGKPALEAQVAGQAKNLIGQTQQLTFREVKEGDAIYYLAELPVTHEETFTFDIDVKSGNKGSGKLQFTQKFYVEE
>NZ_CP016349.1|WP_014233036.1|2984964_2985255_+|YggU-family-protein
MSAAVWRDGEDIVLRLYIQPKASRDKIVGLHGEELKIAITAPPVDGKANAHLTKFLAKQFKVAKGLVHIEKGELGRHKQIRIESPTQIPTDIEAIL
>NZ_CP016349.1|WP_065300228.1|2994505_2996131_+|methyl-accepting-chemotaxis-protein
MKLKTQAYLLSAIILLALLALTATGLWTLRVASNLDNKARVTELFKSAYSILTEVEAMAASGELPEDEAKALATRLLRNNIYKDNEYVYVADENMIFVAAPLDPQLHGTSFHDFKDSNNNSVGQLILDILDNKTGQIVEYTWSQTQTDGSIEEKHSIAEKTPHWGWVVGTGIGFNEVNARFWVTAQWQLILCLFIAGAILTSLIIAIRKMLNVLGGEPHDVRQAVQAVSQGNIQTSFDTVAPKDSIYDAVQNMSQSLATMVTNLDSSMLALRSELSAVESRSGTIADLTLSQQESTAMIATAMTEMASSANQVATSANDTARNTDEADKQSQQTQSLICSTVDNIQGLANQLSTASLAVANLDQDVNNIVKVLDVIGDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAGRTQDSTKEIQNMISNLQQGSRHAIQTMEICAETSQSTVTQSQSASEALQQIVTALEAITTMSQQIATAAAEQTHVSDDIAHRINLIEESGYQLNSVVTESQSSTQSLASLANDLEGWVNKFSVKH
>NZ_CP016349.1|WP_065300229.1|3004276_3005530_-|HD-GYP-domain-containing-protein
MAAIKLTVDRIQPGLHIRLPLKWNDHPFLLNSFKIKDQGQVEMIRHLGVKFVYFNPEQSDSLPLPVNQDREDKVKSDDSLDLETKALWQEKQKRIEKLSAYRRRVIQCEKEFERSLARMRSVMMKIRNRPVAAVNEAKQLTEDIVDKLMCDDNVTLHLMNGKNEYEDIYFHSLNVAVIAMMIGRAKGYSANQLKELSFAALFHDMGKVKIPTAILRKQEPLTVPEENYLKLHTKYGLDLANQIEDFPETAKTVIEQHHELRDGSGYPKGLQGDEINEFAQIIIVANAFDNLCHTRITSEQKIPYTALSHLYKNCKHLYKEENLKFLIKFMGVFPPGTVVQLTNNMIGLVISVNASNLLFPNVLVYDPSVPRTQAPILDLASKDLRIVNAIHPSKLPENIKEYLNPRSRISYFFDTDA
>NZ_CP016349.1|WP_014233047.1|3005831_3006506_+|SDR-family-oxidoreductase
MKILVTGASSGIGFELVKQLCADHHDVFATGRNKNKLTELHQLTGCKFASYDLTESQQVMDMFKQATEELGGLDVLINNAGMNTRKCAIDEFSLEEFEQQYAINLRAPAILCREALSLMKEQKSGYIINVTSTVAKRASETMAVYTTMKQGLAGFTGVLMKEAQPHGIKVTNLFPGGTDTNFRAASRPEYMQPESVARTILGLLKLPEDVVVHEMVFRPLVELE
>NZ_CP016349.1|WP_065300230.1|3006645_3007584_-|bile-acid:sodium-symporter-family-protein
MIGRLTQLFPVWAVIFALTAYFSPSLFVDLKSQIVPLLTIIMLAMGISLSPGDFLNVLKHKKAVGVGVFLQFLIMPLAALLISFLLGFSTELTVGMVLVGSVAGGTSSNVMVFLAKGDVALSISMTAISTLLGVILTPLLVEGLIGQSVDVPVSGMLMSLVKIVLLPVSIGVIINTFIPKAVAKVNAILPLISMLAIVVIIAIVVALNAENLNTIGPLVALAVILHNGLGLTAGYYCCRLLGFNESTCRTIAFEVGLQNSGLATALAMKFFSPASAIAGTIFSVWHNISGSLLAGYWASKKARKAKAVTNSL
>NZ_CP016349.1|WP_065300231.1|3008594_3009260_-|SDR-family-NAD(P)-dependent-oxidoreductase
MILITGASSGLGAELAKLYDCDGQPTYLTGRSEGKLSEITNRLSNNIGYQACDLSLHQDVEQLFDQLGQPPQTVIHSAGSGYFGLLEDQEPEQIQKLINNNLNSAINVLRELVKRYKDHSVNVVVIMSTASQQPKAQESTYCAVKWAVKGLIESVRLELKGKPMKIIAVYPGGMATEFWETSGKSLDLSSFMQAEDAAQMIHDAVSSIGNGYVSDITVNRL
>NZ_CP016349.1|WP_065300232.1|3009438_3010707_+|DUF2254-domain-containing-protein
MTGSKWQWLLKQVTRKLWVRTSLFALLAVATALMSIVLNEFVVLPPAINVSSELLNNILNILATSMLAVTTFSLNIMVSAYTAASAGVTPRATKLLMEDSTTQNALATFLGSFLFSLVGIIALGVGAYHEQARIYLFIVTMVVIVMIILTLLRWIQHLSVLGRVSETTSKVEQALISAIRKRGNEPWLGARPWSHPEHKPRGSKPIYSQEIGYLQHIDMHHLDGIAEENQCTIYIERQPGNFVYSGQPIAWLCGELEEESEVSAAFTIRTERSFDQDPRFGLVVLAEIASRALSPAVNDNGTAIDVLGRAIRALSLWGELLKQRPIKTRFPRLFVPSLSCQDLFDDVFLPIAHDGAAQLQVQIRLQKSLLAISSMHPKLFASPAQKLSEKALELALSQHYTEDEKHQLSQLSHQVIDQKFHG
>NZ_CP016349.1|WP_014233051.1|3010900_3011380_+|RDD-family-protein
MTTSTTLPTAGLFRRLAALVYDSLIVIAIEMMAAGVVMAIVFALNAAGLLSYGEYVDAADMLSKHPVISPIFTLYLAVVWIYFFVFFWTRAGQTLGMRAWKLQVRNAADDAPITVTQALIRIATSGFGLANLTVPIDPQKRGFHDMWAKTKVVVLPKAQ
>NZ_CP016349.1|WP_014233052.1|3011410_3012481_-|LPS-export-ABC-transporter-permease-LptG
MFKILDLYIGRTIISTTALVLATFVGLSGIIKYVEQLRKVGRGVYDLMHALYFVLLSIPRDIEMFFPMAALLGALIGLGMLASSSELVVMQAAGFSKLDIGLSVLKTAVPLMLIVMTLGQWGAPEAQKMARDLRSFAISGGSIVSVRAGVWARDANDFIFIGKVEDDKLYALNMWRFDEDKNLQKVIFAEEVDYEQDNNWVMKDVQITDMQGETVISKQSVDQMEWQTSLAPDKLAVVTVKPEELSLSGLYDYVTYLKASEQDASRYELAFWRKLTQPLSIAVMMLMALSFVFGPLRSVTMGARVLSGVVAGFTFYISSEFFGPLTLVYGIPPVFGALAPSLVFLAIAVSLLRRKL
>NZ_CP016349.1|WP_020334475.1|3012484_3013585_-|LPS-export-ABC-transporter-permease-LptF
MIIVRYLIRETLKSQFAIFFVLFLVFLSQKFISVLADASDGDIPAGLIFSIVGLNMPAMGLLMLPLSLYIGILITFGRLYAESEIVVMNATGIGNKFLVQAALYLALITSAVAAFNALWLSPWSQERVEQLYEQVAAENSVDLLQKGQFQGTPDGSSVVFIDDIKDNTLSNVFVAQMRPRDSVLPSVMFSSSGEVKELSDGRQIITMKEGTRYEGVPTRVEYMITKFDQYEGVIGQREVKKKGRDWEAYPTADLIGHPDPEAQAELQWRISLFVCIPLLTMLVIPLSAVNPRQGRFAKMGPAILIYLAYFLAISATKSALEDGSIPTTVGMWPINAMLLIVAILANMMDSVPARRMKEKFRKKRLA
>NZ_CP016349.1|WP_020334476.1|3013785_3015294_+|leucyl-aminopeptidase
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPVAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHQVPGVLSERVLLVGCGKERELGERQYKEIIQKTISTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVEATKDGLYTFNQFKSVKPETRRPLRKLVFNVPTRRELSLGEKAITHGLAIASGVKASKDLGNMPPNVANPAYLASQARRLADDYETVTTKIIGEQEMEKLGMTSYLAVGRGSKNESMMSIIEYKGNPDSDAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGAASVFGTMKALAKLNLPINVIGVLAGCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDVATLTGACVIALGHHISGVLSNHNPLAHELVNASEQASDRAWRLPMADEYHEQLKSPFADMQNIGGRPAGTITAGCFLSKFAKKYNWAHLDIAGTAWKSGAAKGSTGRPVSMLVQFLLNRSGQETEE

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Crispr_ID: NZ_CP016349_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016349_4

3218433-3218547

Orphan

Consensus_repeat	Method
TTGGTTGCGGGGGCCGGATTTGATCCGA	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP016349_4

>merge|NZ_CP016349|4|3218433-3218547|CRISPRCasFinder
TTGGTTGCGGGGGCCGGATTTGATCCGAGCGGCGCATCCGTCGACGACCTGAGGGTTATGATAAATAACAATCAAACTGTCTTGAATTTGGTTGCGGGGGCCGGATTTGAACCGA

>NZ_CP016349|4|3|3218433-3218547|CRISPRCasFinder
TTGGTTGCGGGGGCCGGATTTGATCCGA	GCGGCGCATCCGTCGACGACCTGAGGGTTATGATAAATAACAATCAAACTGTCTTGAAT
TTGGTTGCGGGGGCCGGATTTGAACCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016349.1\|WP_065300302.1\|3214292_3216008_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|236692
NZ_CP016349.1\|WP_014233202.1\|3207039_3207225_+\|DUF2065-domain-containing-protein	unknown	unknown	gnl\|CDD\|225782
NZ_CP016349.1\|WP_014233204.1\|3208282_3209485_-\|FtsH-protease-activity-modulator-HflK	unknown	unknown	gnl\|CDD\|236799
NZ_CP016349.1\|WP_065300301.1\|3212244_3214275_-\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|234630
NZ_CP016349.1\|WP_065300303.1\|3216001_3216466_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl\|CDD\|182615
NZ_CP016349.1\|WP_065300304.1\|3216779_3217907_+\|tRNA-epoxyqueuosine(34)-reductase-QueG	unknown	unknown	gnl\|CDD\|272993
NZ_CP016349.1\|WP_020336194.1\|3228817_3229855_+\|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|234629
NZ_CP016349.1\|WP_020336188.1\|3219979_3220525_-\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
NZ_CP016349.1\|WP_014233219.1\|3228136_3228607_+\|protein-export-chaperone-SecB	unknown	unknown	gnl\|CDD\|180234
NZ_CP016349.1\|WP_014233206.1\|3210858_3211122_-\|RNA-chaperone-Hfq	unknown	unknown	gnl\|CDD\|179001
NZ_CP016349.1\|WP_014233203.1\|3207299_3208280_-\|protease-modulator-HflC	unknown	unknown	gnl\|CDD\|273883
NZ_CP016349.1\|WP_065297472.1\|3221835_3222693_+\|phosphatidylserine-decarboxylase	unknown	unknown	gnl\|CDD\|234591
NZ_CP016349.1\|WP_014233205.1\|3209530_3210820_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|182934
NZ_CP016349.1\|WP_014233218.1\|3227495_3227930_+\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP016349.1\|WP_065300305.1\|3222871_3224287_+\|SLC13/DASS-family-transporter	unknown	unknown	gnl\|CDD\|238535
NZ_CP016349.1\|WP_065297471.1\|3220654_3221719_+\|small-ribosomal-subunit-biogenesis-GTPase-RsgA	unknown	unknown	gnl\|CDD\|237039
NZ_CP016349.1\|WP_065300306.1\|3224451_3225339_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|307170
NZ_CP016349.1\|WP_014233221.1\|3229927_3230749_+\|serine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|182987
NZ_CP016349.1\|WP_014233217.1\|3225410_3226943_-\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|235463
NZ_CP016349.1\|WP_014233207.1\|3211315_3212248_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626

Protein	Function_ID	Function_description	E-value
NZ_CP016349.1\|WP_065300302.1\|3214292_3216008_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|236692	PRK10431, PRK10431, N-acetylmuramoyl-l-alanine amidase II; Provisional.	5.30935e-84
NZ_CP016349.1\|WP_014233202.1\|3207039_3207225_+\|DUF2065-domain-containing-protein	gnl\|CDD\|225782	COG3242, COG3242, Uncharacterized protein conserved in bacteria [Function unknown].	1.42113e-18
NZ_CP016349.1\|WP_014233204.1\|3208282_3209485_-\|FtsH-protease-activity-modulator-HflK	gnl\|CDD\|236799	PRK10930, PRK10930, FtsH protease activity modulator HflK.	8.92183e-163
NZ_CP016349.1\|WP_065300301.1\|3212244_3214275_-\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	0
NZ_CP016349.1\|WP_065300303.1\|3216001_3216466_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl\|CDD\|182615	PRK10646, PRK10646, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE.	5.03842e-85
NZ_CP016349.1\|WP_065300304.1\|3216779_3217907_+\|tRNA-epoxyqueuosine(34)-reductase-QueG	gnl\|CDD\|272993	TIGR00276, iron-sulfur_cluster-binding_protein, epoxyqueuosine reductase. This model was rebuilt to exclude archaeal homologs, now that there is new information that bacterial members are epoxyqueuosine reductase, QueG, involved in queuosine biosynthesis for tRNA maturation. [Protein synthesis, tRNA and rRNA base modification].	0
NZ_CP016349.1\|WP_020336194.1\|3228817_3229855_+\|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase	gnl\|CDD\|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	0
NZ_CP016349.1\|WP_020336188.1\|3219979_3220525_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	4.65735e-139
NZ_CP016349.1\|WP_014233219.1\|3228136_3228607_+\|protein-export-chaperone-SecB	gnl\|CDD\|180234	PRK05751, PRK05751, preprotein translocase subunit SecB; Validated.	1.48292e-85
NZ_CP016349.1\|WP_014233206.1\|3210858_3211122_-\|RNA-chaperone-Hfq	gnl\|CDD\|179001	PRK00395, hfq, RNA-binding protein Hfq; Provisional.	5.06895e-49
NZ_CP016349.1\|WP_014233203.1\|3207299_3208280_-\|protease-modulator-HflC	gnl\|CDD\|273883	TIGR01932, Protein_HflC, HflC protein. HflK and HflC are paralogs encoded by tandem genes in Proteobacteria, spirochetes, and some other bacterial lineages. The HflKC complex is anchored in the membrane and exposed to the periplasm. The complex is not active as a protease, but rather binds to and appears to modulate the ATP-dependent protease FtsH. The overall function of HflKC is not fully described. [Protein fate, Degradation of proteins, peptides, and glycopeptides, Regulatory functions, Protein interactions].	9.60243e-152
NZ_CP016349.1\|WP_065297472.1\|3221835_3222693_+\|phosphatidylserine-decarboxylase	gnl\|CDD\|234591	PRK00044, psd, phosphatidylserine decarboxylase; Reviewed.	0
NZ_CP016349.1\|WP_014233205.1\|3209530_3210820_-\|GTPase-HflX	gnl\|CDD\|182934	PRK11058, PRK11058, GTPase HflX; Provisional.	0
NZ_CP016349.1\|WP_014233218.1\|3227495_3227930_+\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	1.29091e-25
NZ_CP016349.1\|WP_065300305.1\|3222871_3224287_+\|SLC13/DASS-family-transporter	gnl\|CDD\|238535	cd01115, SLC13_permease, Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.	9.5452e-67
NZ_CP016349.1\|WP_065297471.1\|3220654_3221719_+\|small-ribosomal-subunit-biogenesis-GTPase-RsgA	gnl\|CDD\|237039	PRK12288, PRK12288, small ribosomal subunit biogenesis GTPase RsgA.	0
NZ_CP016349.1\|WP_065300306.1\|3224451_3225339_+\|DMT-family-transporter	gnl\|CDD\|307170	pfam00892, EamA, EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.	9.8736e-10
NZ_CP016349.1\|WP_014233221.1\|3229927_3230749_+\|serine-O-acetyltransferase	gnl\|CDD\|182987	PRK11132, cysE, serine acetyltransferase; Provisional.	0
NZ_CP016349.1\|WP_014233217.1\|3225410_3226943_-\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	gnl\|CDD\|235463	PRK05434, PRK05434, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase.	0
NZ_CP016349.1\|WP_014233207.1\|3211315_3212248_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	2.09395e-169

>NZ_CP016349.1|WP_065300304.1|3216779_3217907_+|tRNA-epoxyqueuosine(34)-reductase-QueG
MNYEQLAQQIKIWGKELGFQKVGICDVDLSEHEAALQQWLDAGYHGSMDWMARHGMMRARPHELLPGTIRVISARMDYLPPEAQFASNLANKNHAYISRYALGRDYHKLVRKQLNKLGKLIEEEVGKFGYRPFVDSAPILERPLAQKAGLGWTGKHSLILDKDCGSWFFLGELLIDLPLPVDKPSVEQCGKCKACITSCPTQAIVDDKVVDARRCISYLTIEFDGIIPEEFRKPMGNRIYGCDDCQLVCPWNRYADITEQEDFHRRDSFQHPDLVDMFGWDEATFLKNMEGSAIRRIGHLQWLRNIAVALGNAEYSQRVIDALVSRQGESDLLDEHIIWALNQQLNQTPVNETESVETKKNRLIRIVEKGLPRDA
>NZ_CP016349.1|WP_065300303.1|3216001_3216466_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MSTKQFNLKDEHETVALGTALAQLCSQQTTIYLHGDLGAGKTTFSRGFVRALGHQGNVKSPTYTLVEPYQLDKWQVYHFDLYRLADPEELEFMGIRDYFTDDAICLVEWPEKGQGLLPEPDLDVNIRYQGEARIAELTANNDYGVQLLSRLELC
>NZ_CP016349.1|WP_065300302.1|3214292_3216008_-|LysM-peptidoglycan-binding-domain-containing-protein
MLSFSNFRVVATFVATFLLIIPSLAFANVVKSFRVWPSPDETRVVIDLGSEADYSYFSLSEPDRLVVDLKDATMQAKLPVTVSDSPVLTRVRKSSPPETGTYRLVFELKKSVQAELFKLSPTPGGQYGHRLVIDLPHGTKTATTATKSEEKTTTSKDMSSVQRAQEVLIVIDPGHGGEDPGSIGPSRRKYEKDAVLSISRKIAAQLNATPGIKTRLTRSGDYFVNLNRRVAIARENDAHLLISIHADAFTSPRPRGGSVFVLNTRRANTEISRWVENHERQSELLGGSGNAFVSNTKDRNVNQTLLDLQFSHSQKEGYKLATEILGEMGRVAHLHNTKPINTSLAVLRSPQIPSVLVETGFISNPTEEKLLFQRAHQDKLAQSISKAVVKYLKDNPPEGTVFSPSSKPMVHIVKRGESLSVIANKYGTSSKAIMAENNLKSSGLGIGQKLRIPSAGNIKVPSKPITVETETITHTVKSGEFLGKIASHYKVKVSDIRRENNLKSDTLWVGQKLKVTVAVKDKPIRKHKVSRGEYLGKIASKYDVSVQSIREANNLRSDELAVGQVLIIPNK
>NZ_CP016349.1|WP_065300301.1|3212244_3214275_-|DNA-mismatch-repair-endonuclease-MutL
MTIKILPARLANQIAAGEVVERPASVIKELVENSLDSGATRIDIDIEKGGAKLIRVRDNGKGIAKDELGLALSRHATSKIHSLDDLEAIMSLGFRGEALASISSVSRLTLTSRPAAQEEAWSAYSEGREMQVKLQPAAHPIGTTVEVLDLFFNTPARRKFLRTEKTEFSHIDELLKRIALSRFDVSITVRHNGKIIRQYRAAKNQLQTEKRIAAVCGNAFVRNMLRIELEHQGLKLHGWITTPDGARQQSDLQYCYVNGRMMRDKLINHAIRQSYEMSLKPDQFAAYVLFIELDPHQVDVNVHPAKHEVRFHQARLVHDFIYQALTDALVQSAVIEQPHVNESAFHHAEPSSPVEERDVDSAPSISEASIKEDKVSSPVPERVYQAIDKTPAYPGRSDYEAKPRERSSSESSVREARQSDSYHRSDWIESKPAPKPTQSKERHAEPAPSKQEVRAYHELLKTPDLEPKPIENAVVATSREQATLPQVTALGKALAVVDEQFVLMSSDSGVALVSLPRAEFYRVKGQLTPSEGALKAQPLLVPLSLKLDAELVKLAEDYQQDFSQLGIQLKARNDKALMVMGVPAPLRQQNLQNLVPDLLSYAQTWVKGEKTTTQMLSALIDWLALRVTTVKSNYTLSEAIQIIAELEQLRHGQLPLEDTQFVSAVDFSATIAKLTP
>NZ_CP016349.1|WP_014233207.1|3211315_3212248_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MTEKLPLALFLMGPTASGKTELAIRLRQKFPVEIISVDSALIYKGMDVGTAKPDERELSLAPHRLIDILDPSESYSAADFRRDALQAMDDIVAEGKIPLLVGGTMLYYKALLEGLSPLPAANPEIRQQIEQEALTKGWSVLHDELKEIDPVSAERIHPNDPQRLSRALEVFRISGKTLTELTQTKGERLPYRVKQFAIAPKDRAELHRRIELRFEKMMEAGFEDEMKALYARKDLHPDLPSIRCVGYRQMWEYLDGECTREEAIFRGVCATRQLAKRQITWLRSWDDLTWLDSDNIEQSLETISEAIASD
>NZ_CP016349.1|WP_014233206.1|3210858_3211122_-|RNA-chaperone-Hfq
MAKGQSLQDPFLNALRRERIPVSIYLVNGIKLQGQIESFDQFVILLKNTVNQMVYKHAISTVVPARPVSHHSGERTQGDRPQEKSED
>NZ_CP016349.1|WP_014233205.1|3209530_3210820_-|GTPase-HflX
MFDRYESGERAVLVHINFTQEGEWEDLAEFEMLVSSAGVETLQVVTGSRQSPHPKYYVGEGKAQEIATAVQLTGAEIVIFNHSLSPAQERNLETLCKCRVLDRTGLILDIFAQRARTHEGKLQVELAQLRHISTRLIRGWTHLERQKGGIGLRGPGETQLETDRRLLRDRIKAILRRLEKVAKQREQGRRARNRAEIPTISLVGYTNAGKSTLFNRITEAGVYAADQLFATLDPTLRKIELADVGPAILADTVGFIRHLPHDLVAAFKATLQETQEADILLHVVDASDERFRENIQAVHEVLEEIDAHEVPSLVVMNKIDNLESQNPRIERDEEGVPRSVWVSAMEGMGIELLFEALTERLASQMVEHQLCIPPQYQGRFRSTFFQMNCIQREEYDQEGNLLIDIRMQQVDWSRLEKREGAVLTGFIVT
>NZ_CP016349.1|WP_014233204.1|3208282_3209485_-|FtsH-protease-activity-modulator-HflK
MAWNEPGNNNGNDGRDNDPWGNNNRGGQRPGGRDQGPPDLDEVFNKLSQKLGGKFGKKGGGGSPLGGGGSAIGFGVIALIAVAVWFFAGFYTIGEAERGVVLRLGKYDRIVEPGLNWRPRFIDEYEAVNVQAIRSLRASGLMLTKDENVVTVGMDVQYRVTDPYKYLYRVTNADDSLRQATDSALRAVIGDSLMDSILTSGRQQIRQTTQETLNQIMDSYDMGLVLVDVNFQSARPPEQVKDAFDDAIAAREDEERFIREAEAYKNEILPKATGRAERLKKEAQGYSERVTNEALGQVAQFEQLLPEYQAAPGVTRDRLYIDAMEEVYTSTSKVLIDSESSGNLLYLPIDKLSGQEGQTDTKRKSKSSSTYDQIQLESERTQEDTSNTQSRSTGSRQGRY
>NZ_CP016349.1|WP_014233203.1|3207299_3208280_-|protease-modulator-HflC
MRKLMIPVLVIALALMLMSLFVIPEGERGIVVRFGRVLKDNNDITRIYEPGLHFKMPLFDRVKTLDARIQTMDGRADRFVTSEKKDVIIDTYVKWRIEDFGRYYLATGGGNSLTAEALLERKVTDVLRSEIGAREIKQIVSGPRNNDVLPEDASSDEVTTEAAREALEIDGERDLIMSNVLKDTRESAMKDLGVRVVDFRMKKINLPDEISESIYRRMRAERESVARKHRSQGREKAEVIRAQAELEVATILAEADKTARVTRGGADAEAAKIYSNAYNKDPEFFSFLRSLRAYEKSFSSKNDILVLDPKSDFFQYMNNSKGVKAE
>NZ_CP016349.1|WP_014233202.1|3207039_3207225_+|DUF2065-domain-containing-protein
MSESIWLAVGLVLIVEGIGPLVAPNGWRNMVAQLSEQPNNQLRRIGGCLVVAGAVIAIMMS
>NZ_CP016349.1|WP_020336188.1|3219979_3220525_-|oligoribonuclease
MSFSDQNLIWVDLEMTGLDPETHKIIEIASIVTDSELNILAEGPVLAVHQPEEELAKMDDWCTNTHTASGLVERVRNSKVTEQDAVAQTIAFLEQWVPKGASPICGNSIGQDRRFLYKHMPELEEYFHYRYLDVSTLKELTRRWKPEVLDGFSKQGTHLALDDIRESIAELKYYRETIFKI
>NZ_CP016349.1|WP_065297471.1|3220654_3221719_+|small-ribosomal-subunit-biogenesis-GTPase-RsgA
MAKKKKLTKGQVRRVRNNQQKRLKKQEESIQWDENMLGASKQGLVITRFGQHADIEDLETGQVQRCNLRRGVESLVSGDRVLWREGLESMAGISGVVEAVEPRTSMLTRPDYYDGLKPVAANINQMVIVSSVLPELSLNIIDRYLVAAETLSIAPLLVLNKVDLLEDDDRATYEEWLKEYERIGYKVLFVSKKSGEGIKELEAQLRDRINIFVGQSGVGKSSLVNALMPELEQEVEEGEISENSGLGQHTTTAARLYHIPTGGDLIDSPGVREFGLWHLEAEEVTKAFVEFRPYLGGCKFRDCKHNDDPGCILREAVEKGEVSEVRFENYHRILESMGENKANRQYSRSKKADL
>NZ_CP016349.1|WP_065297472.1|3221835_3222693_+|phosphatidylserine-decarboxylase
MDKIKVGLQYWIPQHGLTRLMGKLASSKAGSLTTAVIRWFIKQYNVNMDEAKHSDPKHFKTFNEFFVRELKEGARPIAEGEAVITHPADACVSQFGPIEDGQLIQAKGHNFSAQELLGGDAKLAEEFQDGSFATLYLSPRDYHRVHMPCDGTLRQMIYVPGDLFSVNPLTAENVPNLFARNERVVCIFDTEFGPMAQVLVGATIVGSIEQVWAGTITPPRGNTVYKWDYPAEGNKAVILKKGEEMGRFKLGSTVINLFAKDAITFDESMENGKTTVMGTPYAHKQ
>NZ_CP016349.1|WP_065300305.1|3222871_3224287_+|SLC13/DASS-family-transporter
MPKMSVSTLVKLLVCFLIPLGVLMMPIDAIPIDDLTLIQHRLLAIFLLAALLWVLEPVPVFATSILIIALELIMISDKGLHLFRAPPAGHDLGDLIAYTDIFSAFSSPIIILFMGGFALAIAASKYDLDNNLARVLLKPFGTQPKFIMLGLMLITAVFSMFMSNTATTVMMLALLGPIVASAPKGDLGIKALVLCIPIAANTGGIATPIGTPPNAIALQYLTGENTIDFLSWMMMGLPFVLIQLTIAWFLLQKLFPSSEAEMKLKLNGTFKRSWRAYVVYVTFAMTILLWMTTKAHGMNTYVVAIIPLAIFTLTGIMGKEELKLINWDVLWLVAGGIAIGIALDKTGLAEALAHAIDYESLSPFAVVIALSIVCWLMANFMSNTATANLLMPIAAAIGASMPSLASIGGLQGLLVVVAFSASLGMILPVSTPPNSLAYSTGLIESKDMAKVGLILGLVGLFIVYGAVLILF
>NZ_CP016349.1|WP_065300306.1|3224451_3225339_+|DMT-family-transporter
MGYEWLALCAAFLWAISSLISVIPAQHLGAFAYSRWRMGCTAVILTTMAWITGGWLSVSMEHVTPMMASGLIGIFIGDTALFACMNRMGPRQAGLLFSCHAVFSTILGYFLFSESMTNTELLGSALVFSGVVMAIFFGRRGQTNNVLEEVKGNIWLGIGLGLTAAMCQALGGIIAKPVMQTSVDPVAASAIRMISAFIAHCLLLVIGVKVARPTQNITWRVFGITALNGFLAMAVGMTLILYALREGNVGMVALLSSTTPIMLLPLLWIYTKRRPNRFAWLGAALAVIGAGILVH
>NZ_CP016349.1|WP_014233217.1|3225410_3226943_-|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase
MSAKKPLALVILDGYGYREDTASNAIANAKTPVMDALIANNPNTLISASGMDVGLPDGQMGNSEVGHTNIGAGRVVYQDLTRITKSIADGEFAETPALVEAIDAAVKAEKAVHIMGLMSPGGVHSHEDHIYAAVEMAAARGAEKIYLHCFLDGRDTPPRSAENSLQRFQDLFAKLGKGRVASLVGRYYAMDRDNNWERVQVAYDLLTQAKAEFTAETAVAGLEAAYAREENDEFVKATAIKAEGEEDAIMQDGDAVIFMNYRADRARQITRAFVPEFDGFEREAFPSLHFVMLTQYAADIPLAIAFPPASLENTYGEWLSKQGQTQLRISETEKYAHVTFFFNGGVESEFDGEERQLVASPKVATYDLQPEMSSPELTEKLVAAIKSGKYDTIICNYPNADMVGHTGVYEAAEKAIEALDESVGKVVEAIKEAGGQLLITADHGNAEMMVDPETGGTHTAHTNLPVPLIYVGDKAVEFKEGGKLSDLAPTMLSLAGLEIPAEMSGDILVK
>NZ_CP016349.1|WP_014233218.1|3227495_3227930_+|rhodanese-like-domain-containing-protein
MQEYIEFFQQNMILSLVWVGLLIAFILNIVKSATAAYKEINVNQLTHLINRENGVVVDIRTQDEYKKGHITDSLHILPSDIKSGSFGSLENHKSDPIILVCKTGQTAQESANLLAKAGFTNVSLLKNGLIAWNEANLPLVRGKK
>NZ_CP016349.1|WP_014233219.1|3228136_3228607_+|protein-export-chaperone-SecB
MAEATPQDAQQNFAIQRIFLKDVSFEAPNSPVVFQKEWNPDVKLDLDTQSRELGEGVYEVVLRLTVTVKNEEETAFLCEVQQGGIFTAEKMEAGQLAHCLGAFCPNILFPYARETISSLVVKGTFPQLNLAPVNFDALFMNYLQQQAQQSEGEAEA
>NZ_CP016349.1|WP_020336194.1|3228817_3229855_+|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase
MTQANTNNAYGKDIAMTVIGAGSYGTSLAISLARNGANVILWGHDPEHMARLEADRANHEFLPDIDFPESLIIESDLEKAVQASRDLLVVVPSHVFGIVLKSCKPFLREDTRICWATKGLEPETGRLLKDVAFDIIGENYSLAVLSGPTFAKELAMGLPTAISVASPDAEFVADLQEKIHCSKTFRVYANSDFIGMQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGAKPETFMGMAGLGDLVLTCTDNQSRNRRFGLALGQGKDVDTAQEEIGQVVEGYRNTKEVWMLSQRMGVEMPIVDQIYQVLYQGKDARLAAQDLLARDKKSEGK
>NZ_CP016349.1|WP_014233221.1|3229927_3230749_+|serine-O-acetyltransferase
MKHCEKQKVWNKIVAEAREMSEQEPMLASFYHATIIKHESLGAALSYILANKLDTASMPAMAVREVIEEAFIADPNITDCAACDICATVNRDPAVSMYSMPLLYLKGYHALQGYRVANWLWSQGRHALATYLQNQISVACQVDIHPAARIGCGIMLDHATGIVIGETAVVEDDVSILQDVTLGGTGKECGDRHPKIREGVMIGAGAKILGNIEVGEGAKIGSCSVVLQPVPPHTTVAGVPAKIVGRPKTDKPSLDMDQGFNGKSQSFIHGDGI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NZ_CP016349.1	2993618-2993656	0	1.0

1. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to position: 2993618-2993656, mismatch: 0, identity: 1.0

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccattctt	Protospacer
***************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NZ_CP041417	Escherichia coli strain STEC711 plasmid pSTEC711_1, complete sequence	296499-296537	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NZ_LN868946	Salmonella enterica subsp. enterica serovar Senftenberg strain NCTC10384 plasmid 4, complete sequence	103821-103859	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	KU052038	Escherichia phage SerU-LTIIb, partial genome	1164-1202	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	KU052038	Escherichia phage SerU-LTIIb, partial genome	3070-3108	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	LN997803	Escherichia coli phage phi467	15124-15162	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NZ_CP023526	Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence	1927-1965	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NZ_CP022660	Salmonella enterica subsp. enterica strain RM11060 plasmid pRM11060-2, complete sequence	52076-52114	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NZ_CP045061	Salmonella enterica subsp. enterica serovar Muenchen strain LG26 plasmid pLG26p2, complete sequence	52082-52120	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NZ_CP045054	Salmonella enterica subsp. enterica serovar Muenchen strain LG24 plasmid pLG24p2, complete sequence	52087-52125	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NZ_CP045058	Salmonella enterica subsp. enterica serovar Muenchen strain LG25 plasmid pLG25p2, complete sequence	52086-52124	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NC_021742	Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence	35426-35464	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	MH791411	UNVERIFIED: Escherichia phage Ecwhy_1, complete genome	13643-13681	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	MH494197	Escherichia phage CMSTMSU, complete genome	196770-196808	4	0.897
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NZ_CP054057	Scandinavium goeteborgense strain CCUG 66741 plasmid pSg66741_1, complete sequence	85815-85853	5	0.872
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	KY653118	Morganella phage IME1369_01, complete genome	696-734	5	0.872
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	LC494302	Escherichia phage SP27 DNA, complete genome	76611-76649	7	0.821
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	LT603033	Escherichia phage vB_Eco_slurp01 genome assembly, chromosome: I	17117-17155	7	0.821
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NC_027364	Escherichia phage PBECO 4, complete genome	207830-207868	7	0.821
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	NC_049942	Escherichia phage JLK-2012, complete sequence	23524-23562	7	0.821
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	MK817115	Escherichia phage vB_EcoM_phAPEC6, complete genome	52943-52981	8	0.795
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	MH383160	Escherichia phage UB, complete genome	272122-272160	8	0.795
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	MK327931	Escherichia phage vB_EcoM_G17, complete genome	77927-77965	8	0.795
NZ_CP016349_3	3.1\|2993994\|39\|NZ_CP016349\|PILER-CR	2993994-2994032	39	KM507819	Escherichia phage 121Q, complete genome	77938-77976	9	0.769

1. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NZ_CP041417 (Escherichia coli strain STEC711 plasmid pSTEC711_1, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgc	Protospacer
*********************************** . .

2. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NZ_LN868946 (Salmonella enterica subsp. enterica serovar Senftenberg strain NCTC10384 plasmid 4, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatcaag	Protospacer
***********************************.

3. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to KU052038 (Escherichia phage SerU-LTIIb, partial genome) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgc	Protospacer
*********************************** . .

4. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to KU052038 (Escherichia phage SerU-LTIIb, partial genome) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgc	Protospacer
*********************************** . .

5. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to LN997803 (Escherichia coli phage phi467) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgc	Protospacer
*********************************** . .

6. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NZ_CP023526 (Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccagaatg	Protospacer
**********************************   *

7. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NZ_CP022660 (Salmonella enterica subsp. enterica strain RM11060 plasmid pRM11060-2, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttac	Protospacer
**********************************.*. .

8. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NZ_CP045061 (Salmonella enterica subsp. enterica serovar Muenchen strain LG26 plasmid pLG26p2, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttac	Protospacer
**********************************.*. .

9. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NZ_CP045054 (Salmonella enterica subsp. enterica serovar Muenchen strain LG24 plasmid pLG24p2, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttac	Protospacer
**********************************.*. .

10. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NZ_CP045058 (Salmonella enterica subsp. enterica serovar Muenchen strain LG25 plasmid pLG25p2, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttac	Protospacer
**********************************.*. .

11. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NC_021742 (Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagccggcaccaatcaa	Protospacer
*************************.******** **

12. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to MH791411 (UNVERIFIED: Escherichia phage Ecwhy_1, complete genome) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcacaaatcag	Protospacer
******************************** * **

13. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to MH494197 (Escherichia phage CMSTMSU, complete genome) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcacaaatcag	Protospacer
******************************** * **

14. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NZ_CP054057 (Scandinavium goeteborgense strain CCUG 66741 plasmid pSg66741_1, complete sequence) position: , mismatch: 5, identity: 0.872

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccaaatgc	Protospacer
**********************************  . .

15. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to KY653118 (Morganella phage IME1369_01, complete genome) position: , mismatch: 5, identity: 0.872

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgactccggtagccggcaccatatta	Protospacer
****************.********.********* .*

16. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to LC494302 (Escherichia phage SP27 DNA, complete genome) position: , mismatch: 7, identity: 0.821

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aaggtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 ******************************* *  .

17. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to LT603033 (Escherichia phage vB_Eco_slurp01 genome assembly, chromosome: I) position: , mismatch: 7, identity: 0.821

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aaggtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 ******************************* *  .

18. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NC_027364 (Escherichia phage PBECO 4, complete genome) position: , mismatch: 7, identity: 0.821

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aaggtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 ******************************* *  .

19. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to NC_049942 (Escherichia phage JLK-2012, complete sequence) position: , mismatch: 7, identity: 0.821

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
caggtcgccagttcgattccggtagccggcaccatatgc	Protospacer
.*****.******************.********* . .

20. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to MK817115 (Escherichia phage vB_EcoM_phAPEC6, complete genome) position: , mismatch: 8, identity: 0.795

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aatgtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 * ***************************** *  .

21. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to MH383160 (Escherichia phage UB, complete genome) position: , mismatch: 8, identity: 0.795

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aatgtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 * ***************************** *  .

22. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to MK327931 (Escherichia phage vB_EcoM_G17, complete genome) position: , mismatch: 8, identity: 0.795

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aatgtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 * ***************************** *  .

23. spacer 3.1|2993994|39|NZ_CP016349|PILER-CR matches to KM507819 (Escherichia phage 121Q, complete genome) position: , mismatch: 9, identity: 0.769

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aatgtcaccagttcaattccggtagtcggcacaaaataa	Protospacer
 * ***********.***************** *  .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

69324 : 124202

Escherichia_phage(25.0%)

transposase,integrase

attL 104407:104422|attR 116769:116784

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065298946.1\|69324_70161_+\|transposase	transposase	NA	NA	NA	NA
WP_065298948.1\|72259_73699_+	ATP-binding protein	NA	NA	NA	NA
WP_065298949.1\|73726_75319_+	hypothetical protein	NA	NA	NA	NA
WP_065298950.1\|75390_77028_+	SAM-dependent DNA methyltransferase	NA	NA	NA	NA
WP_065298951.1\|77027_78215_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_065298952.1\|78211_79897_+	ATP-binding protein	NA	NA	NA	NA
WP_065298953.1\|79896_80763_+	hypothetical protein	NA	NA	NA	NA
WP_065298954.1\|80775_83970_+	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	4.9e-59	25.1
WP_065298955.1\|83984_85454_+	hypothetical protein	NA	NA	NA	NA
WP_065298956.1\|85518_86538_-	RelA/SpoT domain-containing protein	NA	NA	NA	NA
WP_065298957.1\|86534_87605_-	hypothetical protein	NA	NA	NA	NA
WP_065298958.1\|88431_89769_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_065298959.1\|89761_91504_+	hypothetical protein	NA	NA	NA	NA
WP_065298960.1\|91503_93552_+	hypothetical protein	A0A2H4J185	uncultured_Caudovirales_phage	8.5e-12	23.5
WP_065298961.1\|93548_94007_+	hypothetical protein	NA	NA	NA	NA
WP_065298962.1\|94307_95228_-	DMT family transporter	NA	NA	NA	NA
WP_065298963.1\|95233_95866_-	aldolase	A0A077SK32	Escherichia_phage	3.2e-63	59.2
WP_065297590.1\|95862_97113_-	four-carbon acid sugar kinase family protein	A0A077SLJ7	Escherichia_phage	1.8e-102	48.9
WP_065297589.1\|97180_98731_-	transporter	NA	NA	NA	NA
WP_081280027.1\|98749_99238_-	tripartite tricarboxylate transporter TctB family protein	NA	NA	NA	NA
WP_065297587.1\|99283_100249_-	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_065297586.1\|100320_101394_-	isocitrate/isopropylmalate dehydrogenase family protein	NA	NA	NA	NA
WP_065297585.1\|101440_102097_-	hypothetical protein	NA	NA	NA	NA
WP_155759745.1\|102392_103343_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_065298965.1\|103374_104601_-	MFS transporter	NA	NA	NA	NA
104407:104422	attL	NA	NA	NA	NA
WP_065298966.1\|104863_105760_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_065297582.1\|105909_106362_-	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_065298967.1\|106469_107369_+	EamA family transporter RarD	NA	NA	NA	NA
WP_065298968.1\|107538_108135_-\|integrase	tyrosine-type recombinase/integrase	A0A090C6M9	Clostridium_phage	6.5e-05	31.3
WP_065298969.1\|108294_109047_-	SDR family oxidoreductase	F2NZ40	Diadromus_pulchellus_ascovirus	9.6e-22	32.9
WP_081280029.1\|109443_110415_-	DMT family transporter	NA	NA	NA	NA
WP_065298970.1\|110498_111383_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_065298971.1\|111465_111645_+	hypothetical protein	NA	NA	NA	NA
WP_081280098.1\|112123_113317_+\|transposase	ISL3 family transposase	A9YX10	Burkholderia_phage	2.5e-101	49.2
WP_065298972.1\|114166_114571_+	DUF2000 domain-containing protein	NA	NA	NA	NA
WP_065298973.1\|114567_115320_+	formylglycine-generating enzyme family protein	NA	NA	NA	NA
WP_065298974.1\|115334_115973_+	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_065300413.1\|115985_116594_+	LysE family translocator	NA	NA	NA	NA
WP_065298975.1\|116610_117411_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
116769:116784	attR	NA	NA	NA	NA
WP_065298976.1\|117732_118749_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_025767079.1\|119562_119808_+	DUF1040 family protein	NA	NA	NA	NA
WP_153904563.1\|119870_120047_-	hypothetical protein	NA	NA	NA	NA
WP_053349801.1\|120401_120653_+	hypothetical protein	NA	NA	NA	NA
WP_081280099.1\|121252_121363_+	DUF3265 domain-containing protein	NA	NA	NA	NA
WP_065298977.1\|121389_122160_+	hypothetical protein	NA	NA	NA	NA
WP_081280030.1\|122156_122267_+	DUF3265 domain-containing protein	NA	NA	NA	NA
WP_048625638.1\|122295_122760_+	hypothetical protein	NA	NA	NA	NA
WP_017449629.1\|122912_123197_+	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_050550131.1\|123230_124202_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	2.9e-47	36.9

DBSCAN-SWA_2

738105 : 747700

Shigella_phage(16.67%)

transposase,integrase

attL 724815:724828|attR 749022:749035

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
724815:724828	attL	NA	NA	NA	NA
WP_155759965.1\|738105_739283_-\|transposase	IS3 family transposase	Q716C2	Shigella_phage	6.1e-124	69.5
WP_155760019.1\|739338_739449_+	AlpA family phage regulatory protein	NA	NA	NA	NA
WP_065299192.1\|739538_740018_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_065299193.1\|740021_741119_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_065299194.1\|741276_741864_+	resolvase	A0A219Y9V9	Aeromonas_phage	1.3e-21	39.9
WP_065299195.1\|742107_743745_+	RNA-directed DNA polymerase	A0A0H4TEY7	Erysipelothrix_phage	4.7e-05	24.8
WP_155759966.1\|743771_744479_+	hypothetical protein	NA	NA	NA	NA
WP_065299197.1\|744697_745165_+	DUF4065 domain-containing protein	Q0H268	Geobacillus_phage	2.0e-09	31.2
WP_065299198.1\|745161_746373_+	hypothetical protein	A0A1B0VBT5	Salmonella_phage	1.4e-30	30.1
WP_065299199.1\|746452_747700_-\|integrase	tyrosine-type recombinase/integrase	A0A1V0E8G8	Vibrio_phage	1.3e-119	52.2
749022:749035	attR	NA	NA	NA	NA

DBSCAN-SWA_3

781505 : 788159

Staphylococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014231006.1\|781505_782645_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.7e-62	41.7
WP_014231007.1\|782662_783913_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	6.1e-98	47.4
WP_014231008.1\|784029_784479_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_065299214.1\|784485_785604_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	5.8e-47	37.7
WP_020333699.1\|785621_786275_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	3.1e-32	37.0
WP_014231011.1\|786410_787520_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	2.7e-65	39.3
WP_014231012.1\|787688_788159_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	3.7e-32	48.0

DBSCAN-SWA_4

1500245 : 1551381

Vibrio_phage(22.73%)

capsid,terminase,portal,tail,tRNA,integrase

attL 1500684:1500698|attR 1549272:1549286

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065299506.1\|1500245_1502174_+\|tRNA	threonine--tRNA ligase	A0A2K9L297	Tupanvirus	8.8e-128	37.6
1500684:1500698	attL	NA	NA	NA	NA
WP_076633413.1\|1502177_1502729_+	translation initiation factor IF-3	A0A2L0UZ54	Agrobacterium_phage	2.7e-13	34.4
WP_005377932.1\|1502850_1503045_+	50S ribosomal protein L35	NA	NA	NA	NA
WP_004727974.1\|1503085_1503439_+	50S ribosomal protein L20	NA	NA	NA	NA
WP_020333032.1\|1504080_1504890_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014231614.1\|1505268_1506252_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2H4UW22	Bodo_saltans_virus	5.6e-38	39.9
WP_065299507.1\|1506270_1508673_+\|tRNA	phenylalanine--tRNA ligase subunit beta	A0A1L3IZU3	BeAn_58058_virus	5.1e-08	26.5
WP_065299508.1\|1508950_1510582_+	glycoside hydrolase family 32 protein	NA	NA	NA	NA
WP_065299509.1\|1510646_1511564_-	aminoimidazole riboside kinase	NA	NA	NA	NA
WP_065299510.1\|1511808_1512804_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_065299511.1\|1512821_1513700_-	AEC family transporter	NA	NA	NA	NA
WP_005462650.1\|1514242_1514539_+	integration host factor subunit alpha	A0A0H3UZA0	Geobacillus_virus	2.7e-12	38.9
WP_065299512.1\|1514656_1515433_-	phosphoribosylglycinamide formyltransferase	NA	NA	NA	NA
WP_065299513.1\|1515748_1516399_+	thiopurine S-methyltransferase	NA	NA	NA	NA
WP_065299514.1\|1516491_1517667_-	formate-dependent phosphoribosylglycinamide formyltransferase	NA	NA	NA	NA
WP_065299515.1\|1517814_1518702_-	cytidine deaminase	NA	NA	NA	NA
WP_014231625.1\|1519028_1519706_-	LrgB family protein	NA	NA	NA	NA
WP_020333045.1\|1519707_1520082_-	membrane protein	NA	NA	NA	NA
WP_065299516.1\|1520140_1521562_-	exodeoxyribonuclease I	NA	NA	NA	NA
WP_065299517.1\|1521744_1522941_+\|integrase	site-specific integrase	K7P7J2	Enterobacteria_phage	1.4e-104	47.8
WP_065299518.1\|1523101_1524085_+	hypothetical protein	NA	NA	NA	NA
WP_065299519.1\|1524144_1524993_+	DUF2971 domain-containing protein	NA	NA	NA	NA
WP_065299520.1\|1525147_1525885_+	DUF4062 domain-containing protein	NA	NA	NA	NA
WP_065299521.1\|1525997_1526345_+	hypothetical protein	NA	NA	NA	NA
WP_065299522.1\|1526504_1526984_+	hypothetical protein	NA	NA	NA	NA
WP_065299523.1\|1527119_1527455_+	hypothetical protein	NA	NA	NA	NA
WP_065299524.1\|1527572_1527878_-	hypothetical protein	NA	NA	NA	NA
WP_065299525.1\|1528042_1528315_-	hypothetical protein	NA	NA	NA	NA
WP_065299526.1\|1528494_1529160_-	helix-turn-helix domain-containing protein	A0A1V0E8B5	Vibrio_phage	1.8e-64	55.2
WP_081280061.1\|1529269_1529506_+	helix-turn-helix transcriptional regulator	A0A1V0E8C7	Vibrio_phage	7.4e-13	49.3
WP_020333062.1\|1529608_1530157_+	hypothetical protein	NA	NA	NA	NA
WP_065299527.1\|1530369_1531143_+	helix-turn-helix domain-containing protein	R9TPU9	Vibrio_phage	4.2e-12	31.9
WP_065299528.1\|1531139_1531871_+	DNA biosynthesis protein	A0A1W6JP39	Morganella_phage	4.9e-39	42.2
WP_065299529.1\|1531871_1532453_+	hypothetical protein	NA	NA	NA	NA
WP_065299530.1\|1532568_1532892_-	hypothetical protein	NA	NA	NA	NA
WP_065299531.1\|1533108_1533720_+	hypothetical protein	NA	NA	NA	NA
WP_065299532.1\|1533860_1534316_+	hypothetical protein	NA	NA	NA	NA
WP_065299533.1\|1534508_1534967_+	hypothetical protein	E3T4R8	Cafeteria_roenbergensis_virus	2.6e-06	33.0
WP_155759979.1\|1535279_1535609_+	hypothetical protein	NA	NA	NA	NA
WP_065299535.1\|1535609_1535936_+	hypothetical protein	NA	NA	NA	NA
WP_065299536.1\|1536017_1536230_+	hypothetical protein	NA	NA	NA	NA
WP_065299537.1\|1536337_1536787_+	hypothetical protein	NA	NA	NA	NA
WP_065299538.1\|1537016_1537298_+	hypothetical protein	NA	NA	NA	NA
WP_155760023.1\|1537357_1537729_+	M15 family peptidase	A0A219Y9Z2	Aeromonas_phage	1.7e-16	45.7
WP_065299540.1\|1537769_1537955_+	hypothetical protein	M4SS40	Pseudoalteromonas_phage	6.2e-07	53.3
WP_065299541.1\|1538074_1539289_+\|integrase	tyrosine-type recombinase/integrase	A0A067ZJC5	Vibrio_phage	3.1e-54	32.1
WP_020333076.1\|1539727_1540297_+	hypothetical protein	B0ZSE9	Halomonas_phage	9.2e-25	37.5
WP_076633411.1\|1540307_1542245_+\|terminase	terminase	A2I2W6	Vibrio_virus	1.7e-211	58.2
WP_065299542.1\|1542238_1542766_+	hypothetical protein	A0A193GYL8	Enterobacter_phage	1.3e-25	42.9
WP_020333079.1\|1542765_1544319_+\|portal	phage portal protein	A0A1W6JT60	Escherichia_phage	1.6e-119	43.3
WP_065299543.1\|1544290_1546261_+\|capsid	phage major capsid protein	A0A1W6JT82	Escherichia_phage	4.9e-166	49.8
WP_065299544.1\|1546321_1546513_+	hypothetical protein	NA	NA	NA	NA
WP_065299545.1\|1546505_1546784_+	sugar transporter	NA	NA	NA	NA
WP_065299546.1\|1546780_1547413_+\|tail	phage tail protein	A0A2R9YJK4	Escherichia_phage	1.3e-27	36.9
WP_065299547.1\|1547402_1547849_+\|tail	phage tail protein	NA	NA	NA	NA
WP_065299548.1\|1547851_1548340_+\|tail	phage tail protein	Q687F6	Enterobacteria_phage	2.5e-39	51.0
WP_065299549.1\|1548342_1548816_+	hypothetical protein	NA	NA	NA	NA
WP_065299550.1\|1548839_1549169_+\|tail	phage tail protein	NA	NA	NA	NA
WP_065299551.1\|1549149_1551381_+	hypothetical protein	A0A2I7R469	Vibrio_phage	7.2e-33	34.0
1549272:1549286	attR	NA	NA	NA	NA

DBSCAN-SWA_5

2396486 : 2415805

Vibrio_phage(88.46%)

capsid,terminase,portal,tail,head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065299972.1\|2396486_2397089_-	hemolysin	A0A2I7RNJ4	Vibrio_phage	2.6e-102	85.5
WP_065299973.1\|2397075_2398263_-	hypothetical protein	A0A2I7RNJ7	Vibrio_phage	6.3e-193	82.5
WP_025589745.1\|2398262_2398604_-	DUF2590 family protein	A0A2I7RNH9	Vibrio_phage	4.0e-44	80.9
WP_065299974.1\|2398603_2400442_-\|tail	phage tail tape measure protein	A0A2I7RNI7	Vibrio_phage	5.6e-241	70.6
WP_065299975.1\|2400635_2400899_-	hypothetical protein	A0A1D9C9R9	Salinivibrio_phage	1.7e-18	55.3
WP_065299976.1\|2400895_2401180_-	hypothetical protein	NA	NA	NA	NA
WP_065299977.1\|2401182_2401413_-	hypothetical protein	W6B371	Vibrio_phage	3.5e-07	42.9
WP_045588198.1\|2401409_2401907_-	hypothetical protein	A0A2I7S7C4	Vibrio_phage	2.0e-23	49.6
WP_031856783.1\|2401903_2402122_-	molecular chaperone DnaK	A0A2I7RNJ6	Vibrio_phage	1.2e-22	73.5
WP_047508653.1\|2402134_2402590_-	DUF2597 family protein	A0A2I7RNI0	Vibrio_phage	1.3e-77	94.7
WP_065299978.1\|2402593_2403724_-	DUF2586 family protein	A0A2I7RNI8	Vibrio_phage	8.9e-181	84.0
WP_065299979.1\|2403748_2404417_-	hypothetical protein	A0A1D9C9S1	Salinivibrio_phage	3.7e-41	42.3
WP_065299980.1\|2404406_2404892_-\|tail	phage tail protein	A0A2I7RNH2	Vibrio_phage	5.0e-64	73.0
WP_065299981.1\|2404888_2405308_-\|head	head protein	A0A2I7RNH7	Vibrio_phage	3.8e-52	75.5
WP_065299982.1\|2405422_2406139_-\|terminase	terminase	A0A2I7RNJ0	Vibrio_phage	5.6e-104	83.3
WP_065299983.1\|2406149_2407154_-\|capsid	phage major capsid protein, P2 family	R9TPZ5	Vibrio_phage	4.3e-110	62.8
WP_065300466.1\|2407153_2408011_-\|capsid	phage capsid protein	A0A2I7RNH1	Vibrio_phage	5.5e-98	65.9
WP_065299984.1\|2408177_2409953_+\|terminase	terminase	A0A2I7RNI3	Vibrio_phage	9.4e-302	88.8
WP_025517542.1\|2409949_2410978_+\|portal	phage portal protein	A0A2I7RNI9	Vibrio_phage	1.4e-148	73.8
WP_045607465.1\|2411056_2411308_+	ogr/Delta-like zinc finger family protein	R9TNQ2	Vibrio_phage	1.1e-30	75.9
WP_065299985.1\|2411302_2411566_-	hypothetical protein	Q8HA64	Vibrio_phage	9.8e-14	56.9
WP_065299986.1\|2411647_2413528_-	replication endonuclease	A0A218M4H2	Erwinia_phage	1.5e-63	38.0
WP_025517534.1\|2413533_2413770_-	hypothetical protein	NA	NA	NA	NA
WP_065299987.1\|2413766_2413994_-	hypothetical protein	U3PIK2	Vibrio_phage	4.8e-17	54.7
WP_042765728.1\|2413993_2414194_-	hypothetical protein	A0A2I7RNH0	Vibrio_phage	1.5e-11	67.3
WP_031821624.1\|2414222_2414762_-	phage regulatory protein (CII)	A0A2I7RNI1	Vibrio_phage	9.8e-53	58.1
WP_042765725.1\|2414876_2415089_-	hypothetical protein	U3PFJ1	Vibrio_phage	6.6e-13	52.9
WP_025517523.1\|2415178_2415805_+	phage repressor protein CI	A0A2I7RNF9	Vibrio_phage	1.0e-37	37.9

DBSCAN-SWA_6

2925499 : 2933889

uncultured_Mediterranean_phage(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_024372916.1\|2925499_2926423_-	peptidoglycan DD-metalloendopeptidase family protein	D7RWE0	Brochothrix_phage	1.8e-06	36.4
WP_014232979.1\|2926436_2927063_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	6.7e-37	52.7
WP_014232980.1\|2927062_2927839_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.7e-66	50.6
WP_065300198.1\|2927838_2928882_-\|tRNA	tRNA pseudouridine(13) synthase TruD	NA	NA	NA	NA
WP_014232982.1\|2928924_2929404_-	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	NA	NA	NA	NA
WP_065300199.1\|2929417_2930125_-	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	A0A2H4UTB4	Bodo_saltans_virus	3.1e-06	26.2
WP_014232984.1\|2930126_2930408_-	cell division protein FtsB	NA	NA	NA	NA
WP_014232985.1\|2930865_2932167_-	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	2.7e-136	60.3
WP_020333971.1\|2932248_2933889_-	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	6.5e-156	52.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP016350

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

661 : 16163

Vibrio_phage(78.95%)

integrase

attL 8827:8839|attR 15044:15056

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065300487.1\|661_1039_+	hypothetical protein	A0A2H4J9F9	uncultured_Caudovirales_phage	8.2e-14	45.2
WP_065300488.1\|1155_1788_+	hypothetical protein	NA	NA	NA	NA
WP_065300489.1\|1869_2844_-	DUF968 domain-containing protein	R9TRM9	Vibrio_phage	8.8e-60	43.3
WP_065300490.1\|2836_3148_-	hypothetical protein	R9TNL4	Vibrio_phage	5.7e-45	84.3
WP_065300491.1\|3144_3837_-	DNA-binding protein	R9TMN1	Vibrio_phage	1.1e-85	74.7
WP_081280109.1\|3830_4043_-	hypothetical protein	A0A1V0E856	Vibrio_phage	1.1e-10	50.0
WP_065300492.1\|4053_5010_-	helix-turn-helix domain-containing protein	R9TPU9	Vibrio_phage	1.1e-123	73.2
WP_155760033.1\|5009_5264_-	hypothetical protein	NA	NA	NA	NA
WP_065300494.1\|5253_5454_-	hypothetical protein	A0A0K1LJE4	Vibrio_phage	5.5e-09	55.7
WP_065300495.1\|5614_5884_-	hypothetical protein	NA	NA	NA	NA
WP_065300496.1\|5880_6333_-	hypothetical protein	R9TRN6	Vibrio_phage	5.9e-43	66.4
WP_065300497.1\|6322_6589_-	helix-turn-helix transcriptional regulator	A0A0M4RTV8	Salmonella_phage	7.1e-12	47.7
WP_065301586.1\|6697_7363_+	helix-turn-helix domain-containing protein	Q37946	Enterobacteria_phage	9.3e-69	59.0
WP_155760034.1\|7375_7999_+	hypothetical protein	NA	NA	NA	NA
WP_065300499.1\|8145_8541_+	hypothetical protein	R9TMP0	Vibrio_phage	1.1e-61	88.5
WP_065300500.1\|8580_9399_+	DUF2303 family protein	R9TRN9	Vibrio_phage	7.0e-127	82.4
8827:8839	attL	NA	NA	NA	NA
WP_065300501.1\|9448_9661_+	hypothetical protein	A0A1V0E8D5	Vibrio_phage	3.1e-10	43.3
WP_065300502.1\|9670_10255_+	hypothetical protein	R9TPV7	Vibrio_phage	1.2e-80	76.7
WP_065300503.1\|10336_10600_+	hypothetical protein	R9TNM3	Vibrio_phage	1.4e-33	82.8
WP_065300504.1\|10599_11121_+	single-stranded DNA-binding protein	R9TR60	Vibrio_phage	7.5e-66	72.3
WP_065300505.1\|11194_11380_+	hypothetical protein	NA	NA	NA	NA
WP_065300506.1\|11358_12576_+\|integrase	tyrosine-type recombinase/integrase	R9TMP3	Vibrio_phage	5.1e-190	78.5
WP_065300507.1\|12625_13498_-	hypothetical protein	NA	NA	NA	NA
WP_065300508.1\|13769_14801_-	L-threonine 3-dehydrogenase	R9TPW0	Vibrio_phage	4.5e-22	92.3
WP_020333441.1\|14969_16163_-	glycine C-acetyltransferase	V5LQ39	Emiliania_huxleyi_virus	1.5e-40	29.9
15044:15056	attR	NA	NA	NA	NA

DBSCAN-SWA_2

901277 : 908795

Escherichia_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065300988.1\|901277_902222_+	carbon-nitrogen hydrolase family protein	M1I5Z5	Acanthocystis_turfacea_Chlorella_virus	6.4e-07	26.5
WP_081280141.1\|902253_903639_-	guanine deaminase	NA	NA	NA	NA
WP_065300989.1\|904053_904893_+	aldo/keto reductase	A0A1V0SDE7	Indivirus	2.9e-11	24.8
WP_065300990.1\|904901_905675_-	DeoR/GlpR transcriptional regulator	A0A077SK06	Escherichia_phage	1.7e-53	46.8
WP_065300991.1\|905955_906855_+	NAD(P)-dependent oxidoreductase	A0A077SLF7	Escherichia_phage	1.2e-98	67.0
WP_065300992.1\|906879_908136_+	four-carbon acid sugar kinase family protein	A0A077SLJ7	Escherichia_phage	1.0e-129	56.7
WP_065300993.1\|908147_908795_+	aldolase	A0A077SK32	Escherichia_phage	1.2e-68	62.4

DBSCAN-SWA_3

2036665 : 2050408

Vibrio_phage(69.23%)

terminase,lysis,portal,capsid,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065301569.1\|2036665_2038879_-	hypothetical protein	A0A2H4PI09	Pseudomonas_phage	3.0e-07	49.1
WP_065301570.1\|2038859_2039186_-\|tail	phage tail protein	NA	NA	NA	NA
WP_065301571.1\|2039209_2039653_-	hypothetical protein	NA	NA	NA	NA
WP_065301572.1\|2039655_2040141_-\|tail	phage tail protein	A5LH35	Enterobacteria_phage	4.0e-37	52.9
WP_065301573.1\|2040140_2040584_-\|tail	phage tail protein	S5MW30	Escherichia_phage	5.7e-06	36.2
WP_065301574.1\|2040596_2040875_-	sugar transporter	NA	NA	NA	NA
WP_065301575.1\|2041128_2042952_-\|capsid	phage major capsid protein	R9TPU0	Vibrio_phage	7.9e-288	84.2
WP_065301576.1\|2042929_2044372_-\|portal	phage portal protein	R9TNK3	Vibrio_phage	3.1e-234	82.9
WP_065301577.1\|2044376_2044622_-	hypothetical protein	R9TR37	Vibrio_phage	5.5e-27	80.2
WP_065301578.1\|2044622_2046518_-\|terminase	phage terminase large subunit family protein	R9TMM4	Vibrio_phage	0.0e+00	90.0
WP_065301579.1\|2046489_2047032_-	hypothetical protein	R9TRM5	Vibrio_phage	4.0e-70	74.4
WP_065301580.1\|2047124_2047865_-	hypothetical protein	NA	NA	NA	NA
WP_065301581.1\|2047878_2048364_-\|lysis	lysis protein	A0A1V1FD30	Vibrio_phage	8.1e-22	42.1
WP_065301582.1\|2048345_2048825_-	lysozyme	A0A1U9GSH3	Vibrio_phage	8.5e-48	58.7
WP_005376950.1\|2048811_2049003_-	hypothetical protein	A0A1V1FD92	Vibrio_phage	1.7e-12	54.1
WP_065301583.1\|2049157_2049826_-	hypothetical protein	R9TRM8	Vibrio_phage	1.7e-83	66.5
WP_065301584.1\|2049949_2050408_-	helix-turn-helix domain-containing protein	A0A0P0IRJ4	Acinetobacter_phage	2.1e-19	37.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP016349

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP016350

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection