CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP048406	Mesorhizobium sp. AA22 chromosome, complete genome	11 crisprs	csa3,DEDDh,WYL,cas3,cas5,cas8c,cas7	1	3	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP048406_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_1

38013-38095

Orphan

Consensus_repeat	Method
GCATGATCTTGTCCAAAAAGTCTGCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048406_1

>merge|NZ_CP048406|1|38013-38095|CRISPRCasFinder
GCATGATCTTGTCCAAAAAGTCTGCAACTTTTGGGGTGATGCTCGGTTTCTTTGCCGCATGATCTTGTCCAAAAAGTCTGCAA

>NZ_CP048406|1|1|38013-38095|CRISPRCasFinder
GCATGATCTTGTCCAAAAAGTCTGCAA	CTTTTGGGGTGATGCTCGGTTTCTTTGCC
GCATGATCTTGTCCAAAAAGTCTGCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_065006131.1\|36887_37994_-\|DUF1513-domain-containing-protein	unknown	unknown	gnl\|CDD\|226021
NZ_CP048406.1\|WP_065005898.1\|38098_39178_-\|peptidase-M75,-Imelysin	unknown	unknown	gnl\|CDD\|226020
NZ_CP048406.1\|WP_065005903.1\|44854_46132_-\|4-aminobutyrate--2-oxoglutarate-transaminase	unknown	unknown	gnl\|CDD\|236032
NZ_CP048406.1\|WP_065005895.1\|31494_32001_-\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|223396
NZ_CP048406.1\|WP_065005899.1\|39177_40785_-\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|226019
NZ_CP048406.1\|WP_065005894.1\|30393_31467_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP048406.1\|WP_065005896.1\|32013_33063_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224616
NZ_CP048406.1\|WP_156768170.1\|28470_28812_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065005893.1\|29232_30063_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP048406.1\|WP_065006128.1\|33089_34499_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237673
NZ_CP048406.1\|WP_065005900.1\|40797_41283_-\|bacterioferritin	unknown	unknown	gnl\|CDD\|225104
NZ_CP048406.1\|WP_065005905.1\|47861_48782_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP048406.1\|WP_065006130.1\|36000_36705_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl\|CDD\|224135
NZ_CP048406.1\|WP_065006132.1\|41689_42976_-\|peptidase	unknown	unknown	gnl\|CDD\|226018
NZ_CP048406.1\|WP_065006129.1\|34618_35419_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP048406.1\|WP_065005904.1\|47017_47851_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP048406.1\|WP_065005897.1\|35506_36001_-\|ribosomal-protein-S18-alanine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|223532
NZ_CP048406.1\|WP_065006133.1\|46271_47021_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224049
NZ_CP048406.1\|WP_065005901.1\|41248_41560_-\|(2Fe-2S)-binding-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065005902.1\|43447_44698_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223523

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_065006131.1\|36887_37994_-\|DUF1513-domain-containing-protein	gnl\|CDD\|226021	COG3490, COG3490, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP048406.1\|WP_065005898.1\|38098_39178_-\|peptidase-M75,-Imelysin	gnl\|CDD\|226020	COG3489, COG3489, Predicted periplasmic lipoprotein [General function prediction only].	1.33394e-153
NZ_CP048406.1\|WP_065005903.1\|44854_46132_-\|4-aminobutyrate--2-oxoglutarate-transaminase	gnl\|CDD\|236032	PRK07495, PRK07495, 4-aminobutyrate--2-oxoglutarate transaminase.	0
NZ_CP048406.1\|WP_065005895.1\|31494_32001_-\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|223396	COG0319, COG0319, Predicted metal-dependent hydrolase [General function prediction only].	1.35061e-53
NZ_CP048406.1\|WP_065005899.1\|39177_40785_-\|c-type-cytochrome	gnl\|CDD\|226019	COG3488, COG3488, Predicted thiol oxidoreductase [Energy production and conversion].	0
NZ_CP048406.1\|WP_065005894.1\|30393_31467_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.41595e-88
NZ_CP048406.1\|WP_065005896.1\|32013_33063_-\|PhoH-family-protein	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	2.21474e-152
NZ_CP048406.1\|WP_065006132.1\|41689_42976_-\|peptidase	gnl\|CDD\|226018	COG3487, IrpA, Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism].	0
NZ_CP048406.1\|WP_065005893.1\|29232_30063_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.47349e-26
NZ_CP048406.1\|WP_065006128.1\|33089_34499_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237673	PRK14325, PRK14325, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NZ_CP048406.1\|WP_065005900.1\|40797_41283_-\|bacterioferritin	gnl\|CDD\|225104	COG2193, Bfr, Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism].	3.31931e-78
NZ_CP048406.1\|WP_065005905.1\|47861_48782_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.85293e-105
NZ_CP048406.1\|WP_065006130.1\|36000_36705_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl\|CDD\|224135	COG1214, COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones].	3.35224e-51
NZ_CP048406.1\|WP_065006129.1\|34618_35419_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	8.10297e-33
NZ_CP048406.1\|WP_065005904.1\|47017_47851_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.39905e-133
NZ_CP048406.1\|WP_065005897.1\|35506_36001_-\|ribosomal-protein-S18-alanine-N-acetyltransferase	gnl\|CDD\|223532	COG0456, RimI, Acetyltransferases [General function prediction only].	1.79464e-26
NZ_CP048406.1\|WP_065006133.1\|46271_47021_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224049	COG1124, DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	7.64096e-122
NZ_CP048406.1\|WP_065005902.1\|43447_44698_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223523	COG0446, HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only].	7.58235e-76

>NZ_CP048406.1|WP_065006131.1|36887_37994_-|DUF1513-domain-containing-protein
MKTPLIDRRDFLRAAGTGFVAAMTPSAWAKTLAADAVFATAFVKRDGSYGAAILSEAGKVLHAIDLPARGHDVTFDPVSKRSVVFARQPGTFAVVFDHTGRDEPRTIASVSGRHFFGHGVFSTDGALLYATENDFDNAAGVVGVYDARAKFKRISEFPTYGMGSHELLLLGDGRTIAVANGGIETHPDYGRAELNIATMKPSYVLVDRLTGDLLEKHELPPELHQLSIRHMAADKSGTVWFGCQYRGPGTDRPLLVGRAARGKDLQLLDMPQDVLSGFRNYIGSVAANLAAGTVAVSSPEGNSLAVIDAASGGIVAISALAEVCGVAPDGPSFMATTGTGEILEAGGATRSEPGYVWDNHMLRIEEAE
>NZ_CP048406.1|WP_065006130.1|36000_36705_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MKLLAIDCAANLCAACVYDAAAGKELGRSVFDLGKGHAEHLMAVIEEALRTGGTDYAGVGPIAVSTGPGSFTGLRVGVSAARGLALALKIPAIGVTTLEALAAQAKETFPGRAVLAALDAGRDEIHAALYDEESVLRYGPAVTTLSQAVAMAVDLSPVLAGTAATQIAASAGRAFDIGPTSATADIAVYARLAAAQAAGKKAEGEKPKPLYLRGADAKPQAGFILSRKKAGKKT
>NZ_CP048406.1|WP_065005897.1|35506_36001_-|ribosomal-protein-S18-alanine-N-acetyltransferase
MRIPFLQPRRRDFALEPLTIADSAAMSVLHREDFVRPWTDDEFAALLEQDAVFGYAARETGQGAKPPVGFVLARLAAGEGEILTVAVARSHRRQGLGWQLMDAVLRELHAQRAEALFLEVDETNVAAIALYRRLGFREVGKRPNYYRSPEHGPTGALVMRRDLR
>NZ_CP048406.1|WP_065006129.1|34618_35419_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MIGKIRIFLALGLVVVGSLILVPLQILSMKTGLWRETFVLKIWHRLIIRALGMRIHLKGTLSSQRPLLVASNHISWTDIMVLGSMVDVKFIARADMAGWPLIGMLSKLQRTVFIERERKRSSGDQASEIANRMAKGDAMVLFAEGSTGDGNMILPFKSTLFGAASMAISEGAAETVFIQPVAIVYTRLHGVPLGRRHRPIAAWIGDEDLMPHLKVLMAEGGLDVEVHFGEPVAFSKGSSRKETARLMESQVRDMVQAALADPRPSR
>NZ_CP048406.1|WP_065006128.1|33089_34499_-|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MELNTIERDDIETAAESAVVPSAATRKVFVKTYGCQMNVYDSQRMTDALAADGYVATDAIGEADLVLLNTCHIREKAAEKVYSELGRIREMKAERAQAGREMLVGVAGCVAQAEGSEIIRRSPAVDLVIGPQTYHRLSDVLARVRRGEKIVETDYAIEDKFEHLPQPKRAEIIKRGVTAFLTVQEGCDKFCTFCVVPYTRGSEVSRPVAQIVAEAERLAQAGVREVTLLGQNVNAWHGEGENAEEWGLGRLLFRLAEIPGLARLRYTTSHPRDMDDELIAAHRDLPALMPYLHLPVQSGSDRILKAMNRRHTAKDYLTLLDRIRAARSDIALSGDFIVGFPGETDANFEATMDLVRQVNYASAFSFKYSPRPGTPGAEMADHVPEAVKDERLQRLQALLLKQQQDFGASLVGSTIDTLIEKPGRQAGQKVGRSPWLQPVIVDEKSGEIGEIIQVRITKTGYNSLFAELA
>NZ_CP048406.1|WP_065005896.1|32013_33063_-|PhoH-family-protein
MSAAEVKNLPQNLPSGASDMAHIVLTFDNNKLASALYGQFDENLARLEQKLGVDIRSRGNQLTIKGSASAAEQARRALDNLYGILQKGADIGQSDVDGAVRMAIAADDQLTLPTLERKGKVSAAQISTRKKTIYARSLNQDAYMRALERSELVFGIGPAGTGKTFLAVAHAAMLLERGMVERIVLSRPAVEAGERLGFLPGDMKEKVDPYLRPLYDALYEMMPADKVERAIAAEVIEIAPLAFMRGRTLAHSAVILDEAQNTTPMQMKMFLTRLGENSRMIVTGDPTQIDLPQNTKSGLVEALRILDGVTGMVTVRFNEGDVVRHPLVAEIVKAYDRDGKLARGLGAEG
>NZ_CP048406.1|WP_065005895.1|31494_32001_-|rRNA-maturation-RNase-YbeY
MAEDRKSGGEDLPVPVDIDIAVEAGDWPEEAALTRLVDRAVAAAFAETGVAGRSELSIVFSDDAHIRSLNAGWRGKDKPTNVLSFPAFPLTTGGPLPPMLGDIVLAAETVAREAALEDKPVDNHIIHLVIHGLLHLLGYDHETDAEAEEMEAVERAALARLAIPDPYA
>NZ_CP048406.1|WP_065005894.1|30393_31467_-|HlyC/CorC-family-transporter
MNDKPETAARPDAGSATKPSEQTEESSSPSTTTGSFASEPSPAGPSLFDRVLGLFRQRNGASLREEIADALAETASDAGAFSPGERAMLNNILRLREVRVEDVMVPRADIEAVEITTNLGDLLGLFEQSGHSRMPVYSETLDDPRGMVHIRDVLAHITKIARVRKGRTTRKTAAATLLDLAKVDLTRTIGDLTLIRPVLFVPPSMLASDLMGRMQAMRTQMALVIDEYGGTDGLVSLEDIVEMVVGDIEDEHDEDEPMITQTGEGVFVVDGKAEIDDVAKMIGEDFAAGEHGEYVDTIGGMIFNTLGRVPARGEVVQAIPGFEFHVLDADPRRVKRVRIMETQKGERRRRAVRAEQA
>NZ_CP048406.1|WP_065005893.1|29232_30063_-|alpha/beta-hydrolase
MPWKLDETVETSAGAVAAGRSGNGPALVLAHGWPWSSFSWHRIIPDLARRYRVHWYDMPGYGRSDKAAEQRTSLDVQGKVFAEMLAHWHLERPMVVAHDFGGATTLRAHLLHGCDFERYVLMNVVAMRPWGSEFFDHVGRHVDAFLGLPSHIHRAVVEAYIKGAIVNDIDSGDFEKLVEPWLAEEGRGSFYRQFAQADEKYTAEVEQVFGNITCPVKIICGKDDPWIPLERGKALHALIPRASFETLPGVGHLPQLEAPALVLERLNAFLSRDGED
>NZ_CP048406.1|WP_156768170.1|28470_28812_-|hypothetical-protein
MAMYAAFLCSIAIFIPSLRKQDEAAYGHLISRTARIRGFDRRKALSFERTWFAVTAFFAGLSFLVPLYALSKAVLSWSELGWRDVVGSTSGMLVGLVVLCDFHFLLRRRLGNS
>NZ_CP048406.1|WP_065005898.1|38098_39178_-|peptidase-M75,-Imelysin
MSKRLALVLVLPLVLAGALPASAAAKASDVIQQAIDGFVRPAYARLHEHAGSLTKAMRRLCDAPSQDHLDAARAEFSGTVDAWSVVEIIRIGPITQNNRLERMLFWPDRKSIGLRQVQAALANKDRTAADPAQLATKSVAMQGLGALEFVLYGDSAERLAGKDDPYRCAYGAAVAGNIETIAAEVSDAWNKPDGFAALWANPGPQNALYRDGTEVVTELVGVFINELEMVRDVRLKGFLGSNPQADKPKQAIYWRSQNTARSLTGNLSGMDALFRASQLGEALSPDARWMADSIHIQLVNGAADATAIRGPIDKALADPALRQKLDHFSLVTSSLSTLIGTRLTAEFGLTAGFSSLDGD
>NZ_CP048406.1|WP_065005899.1|39177_40785_-|c-type-cytochrome
MRRRLDFLRRLRRAEGCGLPSQENPRYSWLRGLSLAVVVPLTASAMAGAPEPAGLATSRTDLTPKDLARVIAITRPTKDFSKPEQFEPMQGGAGTSRKDPNKDAFSQSSANITFEEEGTFKLGNALFRKNWVSSPSSTQASDGLGPLFNERACQNCHLKDGRGSPPEGDSGTTSMFLRLARQASTDEERAALAARKVLNFPDPVYGSQLQDLAVPGLRGEGRMRVDYQEQKVTLPDGTVVWLRKPSYSVDDLANGPLDPHTTLSPRMTPPMIGLGLVEQIAPADILAHADPDDRNSDGISGKPNIVRDGQSGELTLGRFGWKAQTPSIRQQAADAFAGDIGISTPEVPNHSGDCTAAEKTCLAMPNGVQERLGPVEAPPPVMDLVTFYSQNLAVPARRDLDEPDVLAGKKLFYDMGCISCHTPKFVTRRGTPNKAQAFQLIWPYSDFLLHDMGPGLADGQAVGEATGSEWRTPPLWGSGLTQTVNGNSFFLHDGRARTLAEAILWHGGEGQKARDRFAAADAADRDALVKFLESF
>NZ_CP048406.1|WP_065005900.1|40797_41283_-|bacterioferritin
MKGEQQIIERLNEALFLELGAVNQYWVHFRLLEDWGYAKLAKKERAESIEEMHHADRIVARIIFLEGHPNLQSVAPLRIGQNVKEVLESDLAGEYDARTAYKRSREICDEAGDYVTMKLFEDLLSDEEGHIDFLETQLDLLASIGEEKYGQLNAASADEAE
>NZ_CP048406.1|WP_065005901.1|41248_41560_-|(2Fe-2S)-binding-protein
MLICHCNIITEKEIEQTIVGLLDQDPWQLIVPAKIYHAMQKRGRCCGCFPNVVETIIRVTENYHARSEASGVDVVSHLDRVRGLRVQYGSRTHERRTADHRAA
>NZ_CP048406.1|WP_065006132.1|41689_42976_-|peptidase
MTARYGRLAAIGATAALTAAIFVLPAKAETDAKAVIKTYSDIALAKYEDSLTTAQALDKAVDALLAKPSVETLTAAREAWKASRVPYQQTEVYRFGNAIVDDWEGKVNAWPLDEGLIDYVAAGYGTESDANALYTANVIANKSIEVDGKKIDATNLTPEFLSGTLQEAGGIEANVATGYHAIEFLLWGQDLHGTGPGAGERPYTDYDLANCTSGNCDRRAQYLKSASDLLVSDLQDMVNEWKDGGATRKNLVDGEPKVGISTILTGMGSLSYGELAGERMKLGLLLHDPEEEHDCFSDNTYDSHLYDAVGIRAAYRGSYTRLDGTVVEGPSVSDMVKEADPAIDKELSDKLDVTVAKMEAIKARALGGEAYDQQIGEGNIEGNATVQAAIDALVDQTKSIERAVGTLKLNAIAFEGSDSLDAPDKVFQ
>NZ_CP048406.1|WP_065005902.1|43447_44698_+|NAD(P)/FAD-dependent-oxidoreductase
MKNGVIIVGAGHAGVQAAASLREDGYDGPVILVGDENELPYHKPPLSKTFIKDQEAKPQPLRGEAFYTGSTIDYRPGIRVDRIDAGRRLELSGGGVLPFDRLILATGSRPRILPLPGSELSGVVSLRSLAEARLIRALSAQSEDVVILGGGFIGLEIAATLKAAGREVTVVEAVDRLLGRAVAPVIARHVRQRLEATGVRILTGTTIARLEGENGHVSAAITTSGERLPAQMVIVGIGVVPNVELAQAAGITIANGIRVDQQMRTSVPEILAIGDAASYRHWLTGSDVRLESVQNATDQARLAARTIVGHADAFAAVPWFWSDIGDMKLQMVGLISGGDSHVVLGDVNENKFSIYHYAGNRLLGIESVNRPGDHMLGRKMLGAGFSPTPQTVPTGPDGLKAALAAFQQEEPVRAAE
>NZ_CP048406.1|WP_065005903.1|44854_46132_-|4-aminobutyrate--2-oxoglutarate-transaminase
MKNSAISERKNQSISRGVGMTTQIYADRAENSEIWDVEGRRYIDFSSGIAVVNTGHRHPKVIEAVKTQLDRFTHTCHQVVPYESYVRLAERLNGMLPGNFEKKTIFVTTGAEAVENAVKIARNATGRPAVIAFAGGFHGRTFMGMALTGKVVPYKVGFGAMPADVFHAPFPVALHGISVADSLAALDRLFKADVDPARVAAIIVEPVQGEGGFYEAPREFMTALRKICDQHGMLLIADEVQTGFARTGKMFAMDHHEVAPDITTMAKSLAGGFPLSAVTGRAEIMDAPNPGGLGGTYGGSPIGVAAAHAVLDVIEEENLCDRANTLGNRLKQRLQSIRDDTPEIVDIRGPGFMNAVEFNDVKKGLPSAEIANAVRLTALDKGLILLTCGVYGNVIRFLAPITIQDGVMNEALDILESSIREVRAA
>NZ_CP048406.1|WP_065006133.1|46271_47021_-|ABC-transporter-ATP-binding-protein
MTSALSVDRLEVVFDRFRALKGVSLEVQSGESFGLVGESGSGKSTLLRAIAGLAPIASGSITVNGKKLGARRHKAFYREVQMVFQDPYGSLHPRQTVDRLLQEPLAIHGFADGEKRIQRALDEVGLGTGFRFRYSHQLSGGQRQRVAIARALILEPSILLLDEPTSALDASVQAEVLNLLEEIRRRRKLTFLMVSHDLAIITHMCERLMVMQNGEAVENLAASDLVKRHVTKGYTRNLLRASDGFVRTA
>NZ_CP048406.1|WP_065005904.1|47017_47851_-|ABC-transporter-ATP-binding-protein
MSTLLDVDDLRVTFPTRTGRIEAVRGVSFSLGRERLGIVGESGSGKSQTGRAIMGLTPPQAEVTARKLAFDGIDLLTALPRDRRALRGKRIAMILQDPKYSLDPVMSIGRQIVETLRTHEKVGKAEARDRALAMLEAVQIRDPARVFDLHPHEVSGGMGQRAMIAMMLIAGPEMMIADEPTSALDVTVQLDVLGILDRLVSERGMGLIFISHDLRLVSSFCDRVIVMYAGKVVEQLAASELGRAQHPYTRGLLNCMPKIGADRHPLPVLDRKPEWAA
>NZ_CP048406.1|WP_065005905.1|47861_48782_-|ABC-transporter-permease
MSAEAIQSRRDWLLSERPASRMQARLGRAYVAWRRFSANRLAFLGLLIIIALLMVAALADVLAPYSPTFGDLKGSRLLAPSAAHWFGTDDLGRDILSRIIFGSRWTLYVVILVAIIAAPIGLLVGAVAGYAGGWIDAILMRITDIFLAFPKLILALAFVAALGPGIENAVLAIAITSWPPYARIARAETLTVRNSDYIKAVQLMGASPFRIVLRHIMPLCISSLIVRVTLDMAGIILTAAGLGFLGLGAQPPLPEWGAMIASGRRFVLDQWWVAGAPGFAILIVSLGFNLLGDGLRDALDPRSGDQ

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Crispr_ID: NZ_CP048406_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_2

417135-417236

Orphan

Consensus_repeat	Method
GCATGATCTTGTCCGAAACCCGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048406_2

>merge|NZ_CP048406|2|417135-417236|CRISPRCasFinder
GCATGATCTTGTCCGAAACCCGGTTCCCACTTTTCGCTGCGGCGGACCCACTTTTCGGAGTCATGCTTTTTGGTTTACGCATGATCTTGTCCGAAAACCGGT

>NZ_CP048406|2|2|417135-417236|CRISPRCasFinder
GCATGATCTTGTCCGAAACCCGGT	TCCCACTTTTCGCTGCGGCGGACCCACTTTTCGGAGTCATGCTTTTTGGTTTAC
GCATGATCTTGTCCGAAAACCGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_027152031.1\|402102_402426_-\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NZ_CP048406.1\|WP_065011519.1\|406009_409129_-\|double-strand-break-repair-protein-AddB	unknown	unknown	gnl\|CDD\|274300
NZ_CP048406.1\|WP_029347441.1\|415817_416114_-\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|224836
NZ_CP048406.1\|WP_065011517.1\|401590_401872_-\|cupin	unknown	unknown	gnl\|CDD\|380387
NZ_CP048406.1\|WP_065011520.1\|409125_409896_-\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|133044
NZ_CP048406.1\|WP_029347437.1\|417244_419026_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP048406.1\|WP_065011524.1\|420156_421767_+\|phosphoenolpyruvate-carboxykinase	unknown	unknown	gnl\|CDD\|236471
NZ_CP048406.1\|WP_065011525.1\|421872_422310_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|181730
NZ_CP048406.1\|WP_065011527.1\|423077_423695_+\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	unknown	unknown	gnl\|CDD\|372627
NZ_CP048406.1\|WP_065011526.1\|422498_422978_+\|peptidoglycan-binding-protein-LysM	unknown	unknown	gnl\|CDD\|236880
NZ_CP048406.1\|WP_065011530.1\|425694_426486_-\|imidazole-glycerol-phosphate-synthase-subunit-HisF	unknown	unknown	gnl\|CDD\|234996
NZ_CP048406.1\|WP_065011672.1\|411412_413977_-\|PAS-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP048406.1\|WP_065011518.1\|402500_406013_-\|double-strand-break-repair-helicase-AddA	unknown	unknown	gnl\|CDD\|274298
NZ_CP048406.1\|WP_029347440.1\|416110_416512_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|225446
NZ_CP048406.1\|WP_082982707.1\|423761_424214_-\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|377229
NZ_CP048406.1\|WP_065011521.1\|409892_411404_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl\|CDD\|225719
NZ_CP048406.1\|WP_065011529.1\|425276_425603_-\|phosphoribosyl-ATP-diphosphatase	unknown	unknown	gnl\|CDD\|179005
NZ_CP048406.1\|WP_065011523.1\|419110_419812_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP048406.1\|WP_065011522.1\|414166_415567_-\|adenosylhomocysteinase	unknown	unknown	gnl\|CDD\|377487
NZ_CP048406.1\|WP_065011528.1\|424292_425252_-\|type-I-pantothenate-kinase	unknown	unknown	gnl\|CDD\|235466

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_027152031.1\|402102_402426_-\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	1.97392e-49
NZ_CP048406.1\|WP_065011519.1\|406009_409129_-\|double-strand-break-repair-protein-AddB	gnl\|CDD\|274300	TIGR02786, conserved_hypothetical_protein, double-strand break repair protein AddB, alphaproteobacterial type. AddAB is a system well described in the Firmicutes as a replacement for RecBCD in many prokaryotes for the repair of double stranded break DNA damage. More recently, a distantly related gene pair conserved in many alphaproteobacteria was shown also to function in double-stranded break repair in Rhizobium etli. This family consists of AddB proteins of the alphaproteobacteial type. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP048406.1\|WP_029347441.1\|415817_416114_-\|HPr-family-phosphocarrier-protein	gnl\|CDD\|224836	COG1925, FruB, Phosphotransferase system, HPr-related proteins [Carbohydrate transport and metabolism].	5.33992e-33
NZ_CP048406.1\|WP_065011517.1\|401590_401872_-\|cupin	gnl\|CDD\|380387	cd06982, cupin_BauB-like, Pseudomonas aeruginosa BauB and related proteins, cupin domain. This family includes bacterial proteins homologous to beta-alanine degradation protein BauB from Pseudomonas aeruginosa, which is involved in the degradation of beta-alanine. Also included are Rhodopseudomonas palustris Rpa4178 and Bordetella pertussis Bp2299, which are both proteins with unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.22417e-47
NZ_CP048406.1\|WP_065011520.1\|409125_409896_-\|nucleotidyltransferase-family-protein	gnl\|CDD\|133044	cd06422, NTP_transferase_like_1, NTP_transferase_like_1 is a member of the nucleotidyl transferase family. This is a subfamily of nucleotidyl transferases. Nucleotidyl transferases transfer nucleotides onto phosphosugars. The activated sugars are precursors for synthesis of lipopolysaccharide, glycolipids and polysaccharides. Other subfamilies of nucleotidyl transferases include Alpha-D-Glucose-1-Phosphate Cytidylyltransferase, Mannose-1-phosphate guanyltransferase, and Glucose-1-phosphate thymidylyltransferase.	1.09353e-95
NZ_CP048406.1\|WP_029347437.1\|417244_419026_-\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.26966e-48
NZ_CP048406.1\|WP_065011524.1\|420156_421767_+\|phosphoenolpyruvate-carboxykinase	gnl\|CDD\|236471	PRK09344, PRK09344, phosphoenolpyruvate carboxykinase.	0
NZ_CP048406.1\|WP_065011525.1\|421872_422310_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|181730	PRK09256, PRK09256, aminoacyl-tRNA hydrolase.	2.69407e-63
NZ_CP048406.1\|WP_065011527.1\|423077_423695_+\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	gnl\|CDD\|372627	pfam13532, 2OG-FeII_Oxy_2, 2OG-Fe(II) oxygenase superfamily.	8.46663e-81
NZ_CP048406.1\|WP_065011526.1\|422498_422978_+\|peptidoglycan-binding-protein-LysM	gnl\|CDD\|236880	PRK11198, PRK11198, LysM domain/BON superfamily protein; Provisional.	3.91229e-65
NZ_CP048406.1\|WP_065011530.1\|425694_426486_-\|imidazole-glycerol-phosphate-synthase-subunit-HisF	gnl\|CDD\|234996	PRK02083, PRK02083, imidazole glycerol phosphate synthase subunit HisF; Provisional.	7.87662e-176
NZ_CP048406.1\|WP_065011672.1\|411412_413977_-\|PAS-domain-containing-sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.80928e-45
NZ_CP048406.1\|WP_065011518.1\|402500_406013_-\|double-strand-break-repair-helicase-AddA	gnl\|CDD\|274298	TIGR02784, ATP-dependent_nuclease_subunit_A, double-strand break repair helicase AddA, alphaproteobacterial type. AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP048406.1\|WP_029347440.1\|416110_416512_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|225446	COG2893, ManX, Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism].	5.88593e-42
NZ_CP048406.1\|WP_082982707.1\|423761_424214_-\|GtrA-family-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	7.09361e-12
NZ_CP048406.1\|WP_065011521.1\|409892_411404_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl\|CDD\|225719	COG3178, COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only].	6.17258e-153
NZ_CP048406.1\|WP_065011529.1\|425276_425603_-\|phosphoribosyl-ATP-diphosphatase	gnl\|CDD\|179005	PRK00400, hisE, phosphoribosyl-ATP diphosphatase.	4.46577e-48
NZ_CP048406.1\|WP_065011523.1\|419110_419812_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.49032e-80
NZ_CP048406.1\|WP_065011522.1\|414166_415567_-\|adenosylhomocysteinase	gnl\|CDD\|377487	pfam05221, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.	0
NZ_CP048406.1\|WP_065011528.1\|424292_425252_-\|type-I-pantothenate-kinase	gnl\|CDD\|235466	PRK05439, PRK05439, pantothenate kinase; Provisional.	0

>NZ_CP048406.1|WP_029347440.1|416110_416512_-|PTS-sugar-transporter-subunit-IIA
MIGLVLVTHGQLAAEFRHAVEHVVGPQDSFETVAIGADDDMEQRRSDIVDAVARVDTGAGVIVLTDMFGGTPSNLAISVMESGRTEVIAGMNLPMLIKLSSIRKGDNMSAALDEAQAAGRKYINVASQLLSSK
>NZ_CP048406.1|WP_029347441.1|415817_416114_-|HPr-family-phosphocarrier-protein
MNALSAKKSDIVREFPIVNQRGLHARASAKFVQVASGFDASVQVEKDGVTVGGTSIMGLMMLAASPGYSIRVTASGPEAEQVIDALEQLVASRFGEES
>NZ_CP048406.1|WP_065011522.1|414166_415567_-|adenosylhomocysteinase
MTGSNDYMVADISLAGWGRKEIEIAETEMPGLMACREEFGKAQPLKGARITGSLHMTIQTAVLIETLKALGADIRWASCNIFSTQDHAAAAIAEAGIPVFAVKGETLEDYWVYTDKIFQWADGGTSNMILDDGGDATMYILIGARAEAGEDVLSNPGSEEEEILFAQIKKRMAASPGFFTKQKEAIRGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRGTDTMMAGKVAVVCGYGDVGKGSSASLKGAGARVKVTEVDPICALQAAMDGFEVVTLEDAAPTADIIITTTGNKDVVTIDHMRAMKDMVIVGNIGHFDNEIQVASLRNLKWTNIKPQVDMITFPDGKRMILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELYTKAGQYQNQVYVLPKHLDEKVARLHLDKLGARLTELSGEQAAYIGVTPQGPFKPEHYRY
>NZ_CP048406.1|WP_065011672.1|411412_413977_-|PAS-domain-containing-sensor-histidine-kinase
MPGDYPPCAGQAVSGGHNDSVTTGSAARGESLLWRAGSRVGKLLASSALAGPLLGLSAHAGPAAASKAGLSVSTVEVMQLAMFVGVMGAALVSAIFLIRERARTSAQNVELRARLADVNAALQRSEALLNLRGQRVVVWASENKKPELVGTLPVESGAPEDRAAFLAFGRWLMPRSAAALENAVAGLREKAKPFDLVLESQAGAPLEVHGRKGAAHVVVRFVSLSETQRSEARLKIENQRLAADYDTMIGLLNALSMPAWLRTANGRLKWVNRAYAKAVEAENAEAAVRDAKEFLGSQARDAIAAQHKSHPVFEQALSTVIEGDRRMFAVTDFAGADGSAGLACDTSAIETIRNEYERTVRSHADTLDQLNTAVAIFDTDEKLRFFNQAFQKLWGLDSGFLHSAPDNALLLDRLRSEGKIAEQPEWRRWKESLLSAYRAVESQEHWWHLPDGKTIRVVANPQPKGGVTWVFENLTEKMDLESRYQTAVRVQGETLDNLAEGVAVFGPDGRLRLSNPAFAALWGLDADAAKPNVHVSTIRDLCDRRAPDSPWRGFVAAITGFDDERRDRHGQTELNNGTVLRYAMIPLPNGQVMMTFVDVTDSVNVERALKDKNEALEKSDQLKNEFVQHVSYELRSPLTNIIGFTELLSLPSTGPLSQKQREYVEHVSSSSSVLLTIVNDILDLATVDAGIMELDISEVHVDRTIAAAAELVSERLEEHAIRLKVDAATAPKTFHGDEIRIRQILYNLLSNAANYAPEASTITLACRSLAEGVEFSVHDDGPGMPPDLLDSVFRRFEPRTNGGRRRGAGLGLSIVKSFVELHGGSVRIETGKDMGTTVICAFPDTPSGIRAAAE
>NZ_CP048406.1|WP_065011521.1|409892_411404_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MAGVVLERFLADEAATARLGEDLAMSLRPGDVLALKGDLGAGKSSLARALIRAMTDDAGLDVPSPTFTLVQSYEARIPVHHFDLYRLSSASELDELGFDEALAQGAALVEWPEQAEAYLPKTSVLIELVHQNDGRLARLSGQGAAFERAARSLAMRDFLKRAGWGEAQRRYLIGDASARSYEIVSLAGLPPRVLMNSPRLVLGPPVRDGRPYALIAHTAQSVSAFVAIDRALRAGGVSAPEVHAQDLDQGFLLLEHLGSEGFLGQQGQPVAERYAAAAELLAMMHGKAWPDRIEIAPGVFHDVPPFDRDAMMIEAELLVDWYVPAISGGPASDALRAGYNREWNAVLNRLEGREYTLMLRDFHSPNIIWRGERTGHDRLGIVDVQDALIGPSAYDLASLAMDARVTIPPEIERRTLDAYIAARHKAGAFNEDEFVETYAIMAAQRNSKILGIFVRLEKRDGKPYYLKHLPRIRDYLRRALAHPALAALRDFYTAHGLLEERSL
>NZ_CP048406.1|WP_065011520.1|409125_409896_-|nucleotidyltransferase-family-protein
MTARPKIAMVLAAGLGKRMRPITDTMPKPLVKISGKTLLDWSLDSLARAGVEKAIVNVHYFPEQIVAHVAARRAPKVVISDESERLLDSAGGIVHALPELGGAPFYIVNADTFWIDSGVPDLARLALAWDAAKMDILLMLADPQSATGHNGGTDFLMSPDGALRRSKGDPTGLIYAGAAIVHPRLFRDAPAGPHSLNAYFDAAISAGRLFGMVMQGHWITVGTPDAIPLAEAAVAAALAESSSAFTALTSAITELK
>NZ_CP048406.1|WP_065011519.1|406009_409129_-|double-strand-break-repair-protein-AddB
MSGFRRVFSIPPGAPFLPTLAKALLSGRLVPGFRFDGDPLALADATIYVPTRRAARALRGVFVDRLGSRSAILPVIRPLGEFDEDEAAFEADASAAIDLAPPIAAIERLLLLAPLVRAWKRRLPAHVAALFDEEIVVPASAADAIWLARDLARLMDEIETEDTDWTKLADLVTGNLAGWWQVTLDFLSIVTENWPNLLEERNRSNPAAHRNALIRLEAARLKRNPPAGPVIAAGSTGSIPATAELLAVIAGLPSGAVVLPGLDLKLDEPSFAAIAAPGARPALLGHPQYGLAKLIGKIGVLRGDVGEIAIAERPLALRAALVGEALRPAETTELWAETRARFTAGDITEAFADVTLLEAAGERDEAVAIAVSLKRAVEQPGQRAALVTGDRALARRVSVELLRFGVVADDSGGTQLINTPAAGLLRLALQVAFRPGDPVALLSLLKHPLLGLGLKRTSVRHAAKIVELVALRGGTGRPDVASLPVLFEARLTGLGSTRPPFWFSRLTVRNIERARELLVRLADALAPLTAFRSQAEADLAELTRASVVALESLGRTADGSLSELYAGDAGEKLAELLRGLIAASASLSFAADEWPDVMEALIAPETVKPAQGTDRNIAIWGALEGRLQSVDTLVVGGLNEGVWPRKPEGDRFMSRLMKTGIDLEPPERRIGLAAHDFQMAMGAKNVVLARSARSGDAPAVPSRWLQRLLTFIGKDHAAVLRRRGDEFLSWARALDAGERRDFAPRPQPKPPLTVRPQHFSVTEIETLRRDPYAIYARRILGLMPLDPVIRDPGAAERGTLFHAILHLFSRTVADPLVSEALDGLIAAGRACFAEAALPPDVEAVWWPRFEKLAAGIIEWERGRAFAVTMRHAEERAEKTGVGQSGVTLSGYADRVDLLAGGMADILDYKTGSSPSKAQAHTLLSPQLALEGALLRRGAFKGLAAREPSQLAFIRLKPNGEVFEESILEYNRKPRTAADLAEEAWARLEKLLIHYADPTTGYLSRALPFREGETDGDYDHLARVLEWSAGGDADDEGGEA
>NZ_CP048406.1|WP_065011518.1|402500_406013_-|double-strand-break-repair-helicase-AddA
MKKAYPIPTDTAASQASASDPQNSAWVSANAGSGKTHVLAQRVIRLLLRGTDPSKILCLTYTRAAAANMSNRVFSTLSEWTALGDVELAARVEALDGRQADRETMRRARRLFAEALETPGGLKIQTIHAFCESVLHQFPLEANIPAHFEMLDPQMEASLFAAARRDMISGTAAGDAGLAEAFATILERGGEHGLDALLAEIVRKRDGLRAFISAAADDSFRALFDEFRFRAGLTAEGLAASVWPLPGFLPDYFVTFARAAEAADARIVLNNLLPYAHLAFAEDDPVRRLQLLAKAFLRADGEPYEPAKTFKKALLDRLPDLAERYLSAADAILEISDRLALFRMVEGTRAALTIADWLIARYEHLKRARGFLDFNDLITRTVNLLARPDAGPWVQYKLDQGIDHILLDEAQDTSPDQWEVVKRLAEEFFAGLGARDTVHRTVFAVGDEKQSIYSFQGAAPDSFADSRLLFAGKVRDANAAFADLKLTWSFRSTDDVLAAVDRVFADPVVRRGISHDPDPLNHKAIRTDAPGYVEVWPSIGADVVDEPDDWTQAVDHAHAPAVRVAENVAATIAGWVGAGEIIEGRGKKLRPGDVLVLVRKRDRFVHALTRALKRRDIPVAGADRLSLPGHIAVKDLIALGHFLVQPEDDLSLAAVLRSPIFDVSEETLFALAGERPSGLSLIASLRQHAGESAALAAIAAQLDTWSDEAAFKPVFEFYAGALARDGLSKKMIARLGPEAGDILDEFLSFCLAEERTGLPGLESFLSTLENAGPEIKREMDQTRDEVRVMTVHAAKGLEAPVVFLVDGGSAPFSDQHLPRLMPFEGSGDHWDGKGYLWRSASDVANGFSRAASVRARELADDEYRRLLYVGMTRAEDRLIVCGYHGKRAPNAGTWHSIVSRALVGAPESAERQHPATGETVHRFHVTKLPPVGHAAAEEARQTTQFEPLPKSLFQPLPPFEDLPRPLSPSGASALIDEAKQAVIDTGSPVLDTEAEPGFAVIRGLALHKLLQMLPGIAEAEHRDAAERYLKRAGAQWPEIERDKALASVATILADSRFDQLFAPNSRAEVAVMGSLEVKGKLRSISGKIDRLAVTPDRVSIVDYKTNRPAPATLADVPSAYVLQLALYRALLQPLYPEHEVSAALLFTEAPRLIELPPAVMDDALARLTGA
>NZ_CP048406.1|WP_027152031.1|402102_402426_-|thioredoxin
MATVKVDKSNFQTDVLDAKEPVVVDFWAEWCGPCKMIAPALEDIAIELGSKVKIAKLNIDENPELAAQFGVRSIPTLMIFKGGEMADMKVGAAPKTALSHWINGNLA
>NZ_CP048406.1|WP_065011517.1|401590_401872_-|cupin
MTGSAKATVFIDNERVIVTEYRFAPGDNTGWHRHGHDYVIVPLMDGKLKLLTKDGESFAEMKKGAPYFRKEGVEHDVINANEGEYAFIEIELK
>NZ_CP048406.1|WP_029347437.1|417244_419026_-|HAMP-domain-containing-protein
MAVDVERVRRTGARRPSRILPAFLSKITVPMRRFLGHHIFSSLTRRILFLNLAGLAVLVTGILYLNTFRDGLIDARVESLMTQGEIIAGAIAASATVETDSISIDPEKLLELQAGESLGPGSDQLDNLDFPINPERVAPVLRRLISPTRTRARIYDRDANLLLDSRHLYSRGQILRYDLPPVDAEEPDLLERVQKFVFDFFRNTALPVYHEQPGGNGAAFPEVVKALTGSPSTIVRISEQGEQIVSVAVPIQRFRAVLGVLMLSTEGGDIDKIVAAERKAILRVFGIAALVTAILSMLLASTIANPLRRLSAAAVRVRRGVKNREEIPDFSDRQDEIGNLSIAVRDMTNALYARIEAIESFAADVSHELKNPLTSLRSAVETLPLAKNDTSRGRLMEIIQHDVRRLDRLITDISDASRLDAELAREDAGTVDLKKFITDLVDVSRTATRNKKTVDIEFKVAKLPQGVKGYFVAGHDLRIGQVITNLIENARSFVPEERGHIAISLARAGKVNIITVDDNGPGIRADNIDRIFERFYTDRPAGEAFGQNSGLGLSISRQIVEAHGGTLTAENIPGTKPGEIKGARFVVTLPAEG
>NZ_CP048406.1|WP_065011523.1|419110_419812_-|response-regulator-transcription-factor
MATIALVDDDRNILTSVSIALESEGYRVETYTDGASALEGLAARPPNLAILDIKMPRMDGMELLRRMRQKSDLPVIFLTSKDDEIDELFGLKMGADDFIRKPFSQRLLVERVRAVLRRASAREASAKTPSQQARSLERGQLVMDQERHTCTWKGEPVTLTVTEFLILHSLAQRPGVVKSRDALMDSAYDEQVYVDDRTIDSHIKRLRKKFKAVDDDFEMIETLYGVGYRFREA
>NZ_CP048406.1|WP_065011524.1|420156_421767_+|phosphoenolpyruvate-carboxykinase
MSEAGKRNPAWAIDRIGLKTTAAVRYNFGEAALYEEAVRRGEARLTAHGALVAETGQHTGRSPKDKFVVRDETTGPHVWWDNNKAISPAQFDTLLADFRAHAADKDLYVQDLVGGADADLKLTTRVVTELAWHSLFIRNLLIRPEAAELEYFVPDLTIIDLPSFRADPVRHGTRTGTVIAVDLSRMIVLIGGTSYAGEMKKSVFTVLNYLLPAKGVMPMHCSANEGAGGDAAIFFGLSGTGKTTLSADPSRTLVGDDEHGWGPHGIFNFEGGCYAKTIKLSAEAEPEIFATTQRFGTVLENVVLDAGRVPDFDDGSLTENTRCAYPLNFIPNASKTGRAGHPKNIIMLTADAFGVMPPIARLTPAQAMYHFLSGYTAKVAGTEKGVTEPEATFSTCFGAPFMPRHPSEYGNLLRELIAHHGVDCWLVNTGWTGGAYGTGKRMPIKATRALLAAALDGSLKGADFRTDANFGFDVPVAVAGVDRAILDPRSTWADTSAYDLQAARLVGMFAINFEKFEPHVDAIVLGAAPRMREAAE
>NZ_CP048406.1|WP_065011525.1|421872_422310_+|aminoacyl-tRNA-hydrolase
MNADDKIIIADDAVIHPDDLHEDFIRSSGPGGQNVNKVATAVQLRFDAANAPGLSERVRERTIKLAGQRVTKDGVIVIEAGRFRTQEQNRADARARLAELVAKAAEPPPPPRKKTRPSKGAVERRLKTKAGRGTIKKLRGRVDDD
>NZ_CP048406.1|WP_065011526.1|422498_422978_+|peptidoglycan-binding-protein-LysM
MGMFDFVKGVGKKLGFGDDEPEPTADTLKKELDSHALGTDNVEVVVEGDTAVLKGVVKDQSIFEKAVIAVGNTLGVSKVQADELQVAAPESGTPAAPAKEPTFYTVKKGDNLWKIAEKSYGKGKGAKNTIIFEANKPMLTHPDKIYPGQVLRIPDLDQA
>NZ_CP048406.1|WP_065011527.1|423077_423695_+|alpha-ketoglutarate-dependent-dioxygenase-AlkB
MLVLPKGVRHMPGYLSRAVQEALVEDVRRVVQDAPLFVPAMPRTGKEMSVRMTNCGSLGWVTDKERGYRYQPTHPVTGAPWPPIPDVLLQLWRDVSAYPHPPEACLVNFYSPDAKMGLHQDRDEIDFSAPVVSVSLGDDCLFRVGQSTREGGTKSFRLKSGDVVVLGGEGRLCFHGVDRIYPSTSALLRNGGRINLTLRRVTYPG
>NZ_CP048406.1|WP_082982707.1|423761_424214_-|GtrA-family-protein
MINMPALRRPDFSTWRGTLAPRRLLKFASVGLAATVLYALCASLFTSAGSTYLSPATASVAAYAVAAIFSYLGHKFFTFMSAGSHQFEAPRFAVLTGFGLAIAYLLPLLLVGQFGLPVVIPILLTCILIPVVNFVVLERWIFSGSVRLGP
>NZ_CP048406.1|WP_065011528.1|424292_425252_-|type-I-pantothenate-kinase
MDQLAPTEKYSPFRFFSAEQWSQFRADTPMTLGEDEVRRLRSLNDPVDLEEVKRIYLSLSRLLSAHVEASQLLFRQRQAFFNAVDVVKTPFIIGIAGSVAVGKSTTARVLKELLARWPSSPKVDLITTDGFLLPNEILRRNNLMERKGFPDSYDVGALLRFLSGIKSAQRNVRAPVYSHLTYDVVPGEFQTIDRPDILIFEGINVLQPGKLPKDGKIVPFLSDFFDFAIYIDAEEELIHQWYIARFMRLRETAFRDPDSFFHRYSQLSQAAARAIAEGLWTNINLKNLRENILPTRARADLILRKGANHLVEEVALRKL
>NZ_CP048406.1|WP_065011529.1|425276_425603_-|phosphoribosyl-ATP-diphosphatase
MAEFSLSDLETIIRERAHSGDPGSWTAKLFARGMDKAAQKLGEEAVETVIAAVGGDRQALVSESADLIYHWLVVLGVAGIPLADVLTELERRTGRSGIAEKASRQDRG
>NZ_CP048406.1|WP_065011530.1|425694_426486_-|imidazole-glycerol-phosphate-synthase-subunit-HisF
MLKARVIPCLDVKNGRVVKGVNFVDLVDAGDPVEAAKAYDAAGADELCFLDITASSENRETIFDIVARTAEQCFMPLTVGGGVRQVADIRKLLLAGADKVSINTAAVKNPDFVAEAADKFGNQCIVIAIDAKKVSGEGEADRWEIFTHGGREKTGIDAVEFAQQMVDRGAGEILLTSMDRDGTKAGYDIALTRAVADAVRAPVIASGGVGTLDHMVEGIRDGHAGAVLAASIFHFGTYSIAEAKAHMARAGLPMRLDSPGDRL

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Crispr_ID: NZ_CP048406_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_3

2103797-2103896

Orphan

Consensus_repeat	Method
TTCGGGCAAGATCATGGTCAAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048406_3

>merge|NZ_CP048406|3|2103797-2103896|CRISPRCasFinder
TTCGGGCAAGATCATGGTCAAACAAGGACCTTGATCCCGAAAAGTGGAAGCCGGTTTTTGCTGCGCTGACCTTCGGTTCGGGCAAGATCATGGTCAAACA

>NZ_CP048406|3|3|2103797-2103896|CRISPRCasFinder
TTCGGGCAAGATCATGGTCAAACA	AGGACCTTGATCCCGAAAAGTGGAAGCCGGTTTTTGCTGCGCTGACCTTCGG
TTCGGGCAAGATCATGGTCAAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_029349710.1\|2110772_2111906_+\|type-III-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|143482
NZ_CP048406.1\|WP_065007584.1\|2093599_2095135_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP048406.1\|WP_065007646.1\|2103081_2103768_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP048406.1\|WP_029349689.1\|2101307_2101688_-\|YciI-family-protein	unknown	unknown	gnl\|CDD\|226318
NZ_CP048406.1\|WP_029349704.1\|2107376_2108045_-\|DUF1007-family-protein	unknown	unknown	gnl\|CDD\|226208
NZ_CP048406.1\|WP_065007582.1\|2097496_2098135_-\|2-dehydro-3-deoxy-phosphogluconate-aldolase	unknown	unknown	gnl\|CDD\|168348
NZ_CP048406.1\|WP_065007574.1\|2106244_2107372_-\|nickel/cobalt-transporter	unknown	unknown	gnl\|CDD\|225125
NZ_CP048406.1\|WP_029349706.1\|2108131_2109031_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP048406.1\|WP_029349714.1\|2112797_2113082_-\|sterol-binding-protein	unknown	unknown	gnl\|CDD\|225794
NZ_CP048406.1\|WP_082982298.1\|2112063_2112735_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|225695
NZ_CP048406.1\|WP_065007578.1\|2101813_2102998_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NZ_CP048406.1\|WP_065007576.1\|2105026_2105233_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|212056
NZ_CP048406.1\|WP_065007645.1\|2109032_2110232_-\|amidase	unknown	unknown	gnl\|CDD\|181375
NZ_CP048406.1\|WP_065007579.1\|2100527_2101283_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP048406.1\|WP_065007581.1\|2098326_2099250_+\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|223982
NZ_CP048406.1\|WP_065007577.1\|2103958_2104963_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
NZ_CP048406.1\|WP_065007586.1\|2090385_2091189_-\|NADH-dehydrogenase	unknown	unknown	gnl\|CDD\|237082
NZ_CP048406.1\|WP_065007575.1\|2105234_2106212_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187549
NZ_CP048406.1\|WP_065007583.1\|2095514_2097389_+\|DUF882-domain-containing-protein	unknown	unknown	gnl\|CDD\|283577
NZ_CP048406.1\|WP_065007585.1\|2091567_2093406_-\|M3-family-oligoendopeptidase	unknown	unknown	gnl\|CDD\|341073

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_029349710.1\|2110772_2111906_+\|type-III-PLP-dependent-enzyme	gnl\|CDD\|143482	cd00622, PLPDE_III_ODC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase. This subfamily is composed mainly of eukaryotic ornithine decarboxylases (ODC, EC 4.1.1.17) and ODC-like enzymes from prokaryotes represented by Vibrio vulnificus LysineOrnithine decarboxylase. These are fold type III PLP-dependent enzymes that differ from most bacterial ODCs which are fold type I PLP-dependent enzymes. ODC participates in the formation of putrescine by catalyzing the decarboxylation of ornithine, the first step in polyamine biosynthesis. Members of this subfamily contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity. Also members of this subfamily are proteins with homology to ODC but do not possess any catalytic activity, the Antizyme inhibitor (AZI) and ODC-paralogue (ODC-p). AZI binds to the regulatory protein Antizyme with a higher affinity than ODC and prevents ODC degradation. ODC-p is a novel ODC-like protein, present only in mammals, that is specifically exressed in the brain and testes. ODC-p may function as a tissue-specific antizyme inhibitory protein.	8.14135e-178
NZ_CP048406.1\|WP_065007584.1\|2093599_2095135_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NZ_CP048406.1\|WP_065007646.1\|2103081_2103768_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	9.75689e-28
NZ_CP048406.1\|WP_029349689.1\|2101307_2101688_-\|YciI-family-protein	gnl\|CDD\|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	2.41158e-46
NZ_CP048406.1\|WP_029349704.1\|2107376_2108045_-\|DUF1007-family-protein	gnl\|CDD\|226208	COG3683, COG3683, ABC-type uncharacterized transport system, periplasmic component [General function prediction only].	1.23246e-78
NZ_CP048406.1\|WP_065007582.1\|2097496_2098135_-\|2-dehydro-3-deoxy-phosphogluconate-aldolase	gnl\|CDD\|168348	PRK06015, PRK06015, 2-dehydro-3-deoxy-phosphogluconate aldolase.	1.65095e-105
NZ_CP048406.1\|WP_065007574.1\|2106244_2107372_-\|nickel/cobalt-transporter	gnl\|CDD\|225125	COG2215, COG2215, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.70888e-104
NZ_CP048406.1\|WP_029349706.1\|2108131_2109031_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.09279e-83
NZ_CP048406.1\|WP_029349714.1\|2112797_2113082_-\|sterol-binding-protein	gnl\|CDD\|225794	COG3255, COG3255, Putative sterol carrier protein [Lipid metabolism].	2.97037e-21
NZ_CP048406.1\|WP_082982298.1\|2112063_2112735_+\|N-acetyltransferase	gnl\|CDD\|225695	COG3153, COG3153, Predicted acetyltransferase [General function prediction only].	5.56482e-48
NZ_CP048406.1\|WP_065007578.1\|2101813_2102998_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	4.68646e-162
NZ_CP048406.1\|WP_065007576.1\|2105026_2105233_+\|hypothetical-protein	gnl\|CDD\|212056	cd11487, SLC5sbd_SGLT2, Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain. Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.	0.00218354
NZ_CP048406.1\|WP_065007645.1\|2109032_2110232_-\|amidase	gnl\|CDD\|181375	PRK08310, PRK08310, amidase; Provisional.	0
NZ_CP048406.1\|WP_065007579.1\|2100527_2101283_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.115e-57
NZ_CP048406.1\|WP_065007581.1\|2098326_2099250_+\|rhodanese-related-sulfurtransferase	gnl\|CDD\|223982	COG1054, COG1054, Predicted sulfurtransferase [General function prediction only].	5.1669e-167
NZ_CP048406.1\|WP_065007577.1\|2103958_2104963_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.73853e-107
NZ_CP048406.1\|WP_065007586.1\|2090385_2091189_-\|NADH-dehydrogenase	gnl\|CDD\|237082	PRK12373, PRK12373, NADH-quinone oxidoreductase subunit E.	1.1836e-33
NZ_CP048406.1\|WP_065007575.1\|2105234_2106212_+\|SDR-family-oxidoreductase	gnl\|CDD\|187549	cd05238, Gne_like_SDR_e, Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs. Nucleoside-diphosphate-sugar 4-epimerase has the characteristic active site tetrad and NAD-binding motif of the extended SDR, and is related to more specifically defined epimerases such as UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), which catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup includes Escherichia coli 055:H7 Gne, a UDP-GlcNAc 4-epimerase, essential for O55 antigen synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	9.98599e-141
NZ_CP048406.1\|WP_065007583.1\|2095514_2097389_+\|DUF882-domain-containing-protein	gnl\|CDD\|283577	pfam05951, Peptidase_M15_2, Bacterial protein of unknown function (DUF882). This family consists of a series of hypothetical bacterial proteins of unknown function.	1.26917e-101
NZ_CP048406.1\|WP_065007585.1\|2091567_2093406_-\|M3-family-oligoendopeptidase	gnl\|CDD\|341073	cd09610, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and is similar to oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid.	0

>NZ_CP048406.1|WP_065007646.1|2103081_2103768_+|GNAT-family-N-acetyltransferase
MPENLKNWQPRPRPERKVLEGRTVRLEPFNAEKHGDGLFDASSVPDIDGRFAWLFDYPPQTRAAFQPWLDKAEASEDPLFFAVIDKASGKVAGRQTLMRIDPAYGVIEIGNIYWGPLISRKPAATEAQFLFMKYIFDELGYRRYEWKCNNRNEPSKRAAERFGFKFEGIFRQHLVVKGENRDTAWYSIIDKEWPALRRAYEAWLDPANFDGDGRQKRRLEDFRAEFGA
>NZ_CP048406.1|WP_065007578.1|2101813_2102998_-|pyridoxal-phosphate-dependent-aminotransferase
MLHTISAFDRLGEENAFAVLARATALAHQGRDIVNLGIGQPDFKTPQHIVEAAIKALRDGHHGYTPANGLLATREAVVRRTLTTTGVEVSPETVMILPGGKPTMFAAILMFGEPGAEILYPDPGFPIYRSMIEFTGAAPVPVPMREENGFAFSAQETLALITPKTRLLILNSPANPTGGVTPRAEIEKLVKGLEAHPDIAILSDEIYDVMTYDGETHCSLLNFPEIRDRLIVLNGWSKTWAMTGWRMGWSVWPNGDKGAHLYDKVRKLAVNCWSCVNAPSQYAGIAAIDGPQDDVDKMMRAFDRRRKVVVEGLNALSGVSCITPKGAFYAFPNVSKTGWKAKKLASALLEDAGVALIGGPDFGILGEGYIRLSYANSEENILRALERIEAFLGK
>NZ_CP048406.1|WP_029349689.1|2101307_2101688_-|YciI-family-protein
MFYAILAYHVEEVVAALTPEEDAALMTDLLQINERLYREGSLGPAARLGATQDACTLRGPGAGMVIDGPFAETKEQLLGLYVVDCATRDAAIAIARDLRRVNPTAVYEIRPISLYLPGVPLSATQS
>NZ_CP048406.1|WP_065007579.1|2100527_2101283_+|SDR-family-oxidoreductase
MTNYKTAIVTGAGTGIGKAVATALLRSGWNTVFCGRRKPVLNKAIDDAGSTQAKALAVACDISKADQVDEMFETVAAAFGRVDLLFNNAGTSYKSTLIDEIPVEVWNEVVGVNLTGSFLCARAAFGAMRRQQPMGGRIINNGSVSAYAPRPGSVPYTATKHAITGLTKTLALDGRPYDIACGQIDIGNALTDMAQAMTVGVPQANGSIAAEAVMDAQQVANAVVHMASLPLDANVLFMTVMATKMPYVGRG
>NZ_CP048406.1|WP_065007581.1|2098326_2099250_+|rhodanese-related-sulfurtransferase
MTLPNQPFRVAALYRFARLDGFEALRAPLAAFCCGRSIKGTLLLAHEGINGTVAGSEADIAALIDHLQSIEGLAGLEVKYSSAAQTPFHRMKVRLKREIVTMGVRDIDPAASAGTYVAPADWNALISDAGTIVIDTRNAYEVSIGTFKGAVDPATTSFREFPAWVEQHRAELVGRTVAMFCTGGIRCEKATAYVKSLGFADVFHLKGGILKYLEEVPAEQSLWQGECFVFDERVSVSHGLVEGEAELCRACRHPLIGQDLLSPKYAAGISCPHCFDARSDEDRARYAERQRQVELAEAQGRAPHIGR
>NZ_CP048406.1|WP_065007582.1|2097496_2098135_-|2-dehydro-3-deoxy-phosphogluconate-aldolase
MPSKTEKLLSLLNGQPVIPVLKIANVADAVPLARALARGGLPAIEITLRTADALEAIRLVASEVEDAVVGAGTILDARQFGEAAAVGSKFIVSPGITRELLATAKDSDVPLLPGAITPGEIMAAREAGLRFLKFFPAEQSGGIASLKAFASPLTDVQFCPTGGITGKNAADYLSLPNVICVGGSWVAPDDLVTAGRWDEIEALARAASKLGR
>NZ_CP048406.1|WP_065007583.1|2095514_2097389_+|DUF882-domain-containing-protein
MSVWPRWLAAVILAFGFLTAAATGASAQTRSLKLYNLHTKEKAEIVFKRGGRYDQAGLKKINVILRDWRRNEPTKMDPRLLDLVWEAYRQSGATDYIQVVCGYRSSSTNSMLRSRSRGVAKKSQHMLGKAMDFYIPGVPLKKLRDIGLRMQGGGVGYYPRSGSPFVHMDVGNVRHWPGISRQELARVFPNGKTLHVPSDGKPLPGYSQALASYKARKGAGAPAIELASAGGGFKKSGGLLAAFFGGGEDEADDSADVAAAPAPKSKSVKLATAKPAPAAKNSKLPGIAIVSPQDAKRAEIPQIADAPAPEPEEDTPETIIAALPARSVPLPDFAPRPKTDVGAQPPENVPFGVADATATTEQAVATAQAPASAPFGMAEPSAVADAAQVAANNIPLPTWRPDHSLPADLAATDLAPQDKDVLLALADTAGHGKTATDAFPVLPSARPDLAQPDLAQPDLAQTDQVQSDAVKAVLERVSATDEYQVASLSQPSSILSDAANGNAASPREAVFTRPAGSDPAAAIGAGVKTTRKAARATARDLKPGPKSVVVAAEPKAARWALNSGENVTTVSSATTAPRYAYNIVHTPPTEVYTAGFQPNDQLADANRFTGNAVKFMSVARFQTK
>NZ_CP048406.1|WP_065007584.1|2093599_2095135_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MTGSILIVDDDPVQRRLLEAAVTKFGHSAIITDGGEAGLDALDGPNARDVSVVILDLVMPGLDGIGVLKAMRERGIQVPVIVQTAQGGIETVVSAMRHGAFDFVVKPASPDRLQASIGNALKVEAVEGEVKRTSRRRGGHLTFKDMITHSPAMDRVIRLGQKAAASNIPILIEGESGVGKELVARAIQGSGDRRSKPFVTVNCGAIPDNLVESILFGHEKGSFTGATEKHTGKFVEAHSGTLFLDEIGDLPLDVQVKLLRAVQDGEVDPVGGRSTIRVDIRLISATHRNLLQQVKDGKFREDLFYRLNVYPIFVPPLRDRRDDIPYLVEHFLEKVAPTDPRHRLHGISAAALTMLQAYDWPGNIRQLENAVFRASVLCEGDVLTEEEFPQIRAQVEGTVNLDADGALHASPLAIEPPGEDVPADNGIAATELDPPARPQPRFGTLRALDERGNVRALADVELEMIKLAIDHYNGQMSEVARRLGIGRSTLYRKLKEYGIDPETGRIDRLAS
>NZ_CP048406.1|WP_065007585.1|2091567_2093406_-|M3-family-oligoendopeptidase
MRMVFGRQLAAAASGQGAAELGDLPEWDLADLYSGMDAPELKRDIARAAADAISFESRWKGTLAAEAERADSGRLGEALAEYEALEELIGRIVSYAGLIYAGNTADPQRAKLYGDIQEKMTDASAHLLFFALELNLIDDAAIETALAADPAFAHYRPWVLDLRMDKPYQLEDRVEQLFHEKSITGRGAWNRLFDETMTDLRFDIDGEELTLEPALNRLQHADGEVRRRASEALAATFRKNLRTFTLVTNTLAKDKEISDRWRGFEDIADSRHLANRVERSVVDALASAVRDAYPRLSHRYYQMKARWLGMEVMNHWDRNAPLPETPQAIIGWDEAKNTVLSAYQRFSPDMAEIARLFFDRNWIDAPVRPGKSPGAFAHPTVPSAHPYVLLNYMGKPRDVMTLAHELGHGVHQVLAAGQGALMASTPLTLAETASVFGEMLTFRSLLDQTTDKRERKAMLAQKVEDMINTVVRQIAFYEFERKVHAERKNGELTSDRLGQFWLEVQAESLGPAIKLRDGYEVFWTYIPHFIHSPFYVYAYAFGDCLVNSLYAVYQNAERGFQEKYFAMLRAGGTKHHSELLAPFGLDATDPAFWQIGLGVIGGLIDELEALDN
>NZ_CP048406.1|WP_065007586.1|2090385_2091189_-|NADH-dehydrogenase
MGTFFYMLLAFLVGVLVGWFIWGRLRGELDSLRGDMDRTRSERDRLRADADRLTGELEVCRGARADLERQLGDAHGTKTGATNAAIPAPSALMATSAPAKTAPAKSTPAKTASKNGPAKTAPATTTSKKPAAAKAAAAPKASASKASASQASAPKLPASKTGAAPKSAASAAKKAATTKAAAGKASNLRRLIGIGPANERLLNGLGVTTYAQIAAWTAADVERIEETLNFDGRIERERWIEQAKLLAAGDEEEFARRFPTGGTASNT
>NZ_CP048406.1|WP_065007577.1|2103958_2104963_+|cation-transporter
MAHTHDHGSHGHDHSHGAGPVHGSTDKKRVLIAACLTAGFMVVEALGGLFTGSLALLADAGHMLADCIALGLAWYAFHLAGRPATVRLTYGFGRVKTLVAYTNGIAIFAIALWIIYEAWERLLTPAPVLGGPMLVVAIAGLLVNIGSFFVLHGGDRDSLNMRGAILHVLGDLLGSAAAIIAALIILATGWTPIDPILSVLVSLLILSTAWSLMREAAHVLLEGVPASLDRDLIARDIEGTVKGVREVHHMHVWSLDGSSNMATLHACLNDGVDAHKAVSAIKKRLAAEHGIAHATVEPEFGHCADSHDSHDGHDGHDGEHDHAHDAAPHHGHCH
>NZ_CP048406.1|WP_065007576.1|2105026_2105233_+|hypothetical-protein
MDRDTRNAAIGALWVLLLFGIAAYYLPTVMLAVGRVSTILAAVIAAVFMVAIFVVFWLRGRSQRKKVH
>NZ_CP048406.1|WP_065007575.1|2105234_2106212_+|SDR-family-oxidoreductase
MRILITGAAGMVGRKLIARLAKDGTLSGRRIAALDLHDIVPPQAPALEGVGVTIHTGDLAAASGMERLVASRPDVIFHLAGVVSGEAEANFDLGYRVNLDGTRALFDAIRLAGFAPRVVFTSSIAVFGAPFPDIIPDEFHPTPLTSYGTQKLMGEALLADYTRRGFFDGIGIRLPTICVRPGKPNKAASGFFSGIIREPLSGQEAILPVPRSVVHTHASPRSAVNFLIHAAGIDGSAVGPRRNLTMPGVAVTVGEQIEALERIAGAEAVKLIREEPDETIWAIVKGWPTRFEARRSRELGFAAETSFDDIIRGHIEDELDGKIAG
>NZ_CP048406.1|WP_065007574.1|2106244_2107372_-|nickel/cobalt-transporter
MTKPSLRLAFGLLAVALVTTHFLGAAHAQSSLGIGTNDGMAPTTGPFAHILMWINLRQQEFYRALAGAMKAMREDGNKLWLLIGLSFAYGVFHAAGPGHGKAVISSYMVANEVALKRGIMLSFVSALLQALTAILVMMLAYFVLRGTTISMTDAAWFLEVTSFVFVTLFGAWLLWRKAGPAILRLFGANPPYSLSAAHAGHSHAGHSHTHSVHALHAHGHDGHDHHHGARDHHHDHSGHDHHHHAAGEVCETCGHSHAPDPTLLSGDRFDWRTAWSAVAAVGIRPCSGALIVLSFAMLNGLWFGGVLSVLAMALGTAITVSILATLAVTAKNWAVYFAGDGRMGNRIHSIVEIGGAAFVFLFGLLLLSASLTAGG
>NZ_CP048406.1|WP_029349704.1|2107376_2108045_-|DUF1007-family-protein
MHLKRQAIIMASAIAATFATVGPAEVHPHVFAEARLEVVLSPDHQTVKALRHLWRFDDLFSSTVMMEFDKNSDLKLDDKELKEVADTVHASLAEFNYFQLVTVDGKDEAMNPPPQLMANFENDQLIILFESEPKAPMKLAGKIDIGVYDPTFYTAIDFTEDANLQVDGMPSTCASKVVRPNPDEALAENQKTLTDAFFNDPTGTDMSKIFATKLELNCQPEG
>NZ_CP048406.1|WP_029349706.1|2108131_2109031_-|LysR-family-transcriptional-regulator
MDTLTRMRAFIDVVEAEGFSAAARKIGRSKALLSKYVRELEDELGALLLNRTTRQFSLTEAGHTYYRRASEIVREVDSLADAVRESSGDVRGRIKLSAPRTFADAPIGQSLIDFAKQHPDIVLDIHLDDRFVDLVEEGFDLAVRISRLENSSLIARRLAPFSVRLCASPELIAKHGMPVRPQDLGRVPCIIDTNGRWLTNWPFKGDSGDTVTVSVSGPIEVNSPMAARAAAVAGLGFSILPDFIAAPDIESGRLVAALDDRILPGGGIFAVYPHRRYLPAKVRVFVDFLVQWFKTIDNA
>NZ_CP048406.1|WP_065007645.1|2109032_2110232_-|amidase
MAGTCGPLNAFLDLDDIPVSNAQAGPLAGLRLAVKDIYDVAGYRTGCGNPQKHREASPASATAPAVQALLDSGARFVGKTQTDELAFSLMGLNAHFPSPVNPAAPDRVTGGSSSGSAAAVAGGLAEIAIGSDTGGSIRAPASFCGLIGLRTTHGRISLEGAMPLAPSLDTFGWFARDMATYEKVGTVLLDDDRQRHDLARALALDALDRLVLGPQQADEYRAMVRTVASLLGAPRTVAPLSHSTDDLYWCFRKLQGYEAWQNHGAWISQDDRMLGPGVKERFEHGATIDLATVQRETERRVSFRLELADLLGEDGVLVLPTAPGAAPLKAASFDELQTYRERALRLLCLSGLSGFPQITLPLGKADGAPFGLSLLGPKNSDRQLLTLAARILSAHQGSA
>NZ_CP048406.1|WP_029349710.1|2110772_2111906_+|type-III-PLP-dependent-enzyme
MATQRILDFLATRRPNGPCLVVDLDVVRDNFRAFEKALPDSKIYYAVKANPAPEILRLLAAMGSSFDTASVAEVEMAMDAGAPADRISFGNTIKKERDIQRAYQLGIRLFAVDCVEEVEKIARVAPGARVFCRVLTDGEGAEWPLSRKFGCVPAMAVDVLRHARTLGLDAYGVSFHVGSQQTDLTAWDRALGDAKKVFLALAEEGIVLKMVNMGGGFPTRYLRDVPVAQAYGQAIFSALRKHFGNAIPETIIEPGRGMVGNAGVIKSEVVLISKKADNDNVRWVFLDIGKFGGLAETMDEAIRYPIMTAHDGTETSPCVLAGPTCDSADVMYEKTPYPLPLSLTIGDEVLIEGTGAYTTTYASVAFNGFEPLRSYVI
>NZ_CP048406.1|WP_082982298.1|2112063_2112735_+|N-acetyltransferase
MAAKRPERVGSAVATSLGLCGAGASGAATPSVALGDISPSRGEIAGAFVITAETAADVSAREALLDRAMGPKRRKKSSEKLRRGRRPSEGLAFIARDASGAVTGTVRLWDVVLGEGGRAALLLGPLAVDPTIKNAGIGSALMRHAMAEAARLGHAAILLVGDAPYYERFGFSAEKTGALAMPGPYERHRLLALELVEGALAEARGTLRAAGRKLKAQRLPLAA
>NZ_CP048406.1|WP_029349714.1|2112797_2113082_-|sterol-binding-protein
MGVQEIADKISARVASAGFDRSVKFDTGSDGVIVIDGADVSTTDAPADCTIKLSLDDLESLIAGDLNPTMAFMSGKIKVEGDMSVAMALSQLIG

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Crispr_ID: NZ_CP048406_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_4

4130976-4131107

Orphan

Consensus_repeat	Method
TGCGTCGACCATGGCGTCGGTCGAACGGAGCGCCGTCCCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048406_4

>merge|NZ_CP048406|4|4130976-4131107|CRISPRCasFinder
TGCGTCGACCATGGCGTCGGTCGAACGGAGCGCCGTCCCTGCGGTCCCCACTAGGGCCGAGCCTCCCAAAACCCTCAGGACGGGACCGGCTGCGTCGACTATGGCGTCGGTCGAACGGAGCGCCGTCCCTGC

>NZ_CP048406|4|4|4130976-4131107|CRISPRCasFinder
TGCGTCGACCATGGCGTCGGTCGAACGGAGCGCCGTCCCTGC	GGTCCCCACTAGGGCCGAGCCTCCCAAAACCCTCAGGACGGGACCGGC
TGCGTCGACTATGGCGTCGGTCGAACGGAGCGCCGTCCCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_163603052.1\|4132495_4133656_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NZ_CP048406.1\|WP_065008243.1\|4123914_4125567_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NZ_CP048406.1\|WP_065008233.1\|4140715_4141861_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP048406.1\|WP_156768311.1\|4137994_4138639_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377913
NZ_CP048406.1\|WP_065008231.1\|4143334_4144990_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008246.1\|4119849_4120203_+\|Rieske-(2Fe-2S)-protein	unknown	unknown	gnl\|CDD\|225057
NZ_CP048406.1\|WP_156768312.1\|4135371_4136709_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240533
NZ_CP048406.1\|WP_082982359.1\|4136699_4137980_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP048406.1\|WP_156768309.1\|4141848_4142667_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133022
NZ_CP048406.1\|WP_082982364.1\|4127793_4128582_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP048406.1\|WP_156768313.1\|4133648_4133999_-\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|181001
NZ_CP048406.1\|WP_163603053.1\|4138739_4140719_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008240.1\|4128684_4128882_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008244.1\|4121997_4123044_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP048406.1\|WP_065008242.1\|4125836_4126070_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225046
NZ_CP048406.1\|WP_082982360.1\|4134095_4135358_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|227940
NZ_CP048406.1\|WP_029353914.1\|4123040_4123925_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP048406.1\|WP_082982365.1\|4126429_4127140_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NZ_CP048406.1\|WP_156768324.1\|4120437_4121925_+\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173868
NZ_CP048406.1\|WP_065008239.1\|4129149_4129947_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_163603052.1\|4132495_4133656_-\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	1.22884e-25
NZ_CP048406.1\|WP_065008243.1\|4123914_4125567_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	0
NZ_CP048406.1\|WP_065008233.1\|4140715_4141861_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.58923e-55
NZ_CP048406.1\|WP_156768311.1\|4137994_4138639_-\|hypothetical-protein	gnl\|CDD\|377913	pfam07760, DUF1616, Protein of unknown function (DUF1616). This is a family of sequences from hypothetical archaeal proteins. The region in question is approximately 330 amino acid residues long.	0.000149097
NZ_CP048406.1\|WP_065008246.1\|4119849_4120203_+\|Rieske-(2Fe-2S)-protein	gnl\|CDD\|225057	COG2146, {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only].	3.81903e-26
NZ_CP048406.1\|WP_156768312.1\|4135371_4136709_-\|hypothetical-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	9.88207e-11
NZ_CP048406.1\|WP_082982359.1\|4136699_4137980_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.27382e-51
NZ_CP048406.1\|WP_082982364.1\|4127793_4128582_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	7.25176e-43
NZ_CP048406.1\|WP_156768313.1\|4133648_4133999_-\|NAD(P)-binding-protein	gnl\|CDD\|181001	PRK07494, PRK07494, UbiH/UbiF family hydroxylase.	1.56654e-07
NZ_CP048406.1\|WP_156768309.1\|4141848_4142667_-\|glycosyltransferase	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	6.0164e-52
NZ_CP048406.1\|WP_065008244.1\|4121997_4123044_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	7.62463e-95
NZ_CP048406.1\|WP_065008242.1\|4125836_4126070_-\|hypothetical-protein	gnl\|CDD\|225046	COG2135, COG2135, Uncharacterized conserved protein [Function unknown].	8.38153e-13
NZ_CP048406.1\|WP_082982360.1\|4134095_4135358_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|227940	COG5653, COG5653, Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane].	1.14831e-36
NZ_CP048406.1\|WP_029353914.1\|4123040_4123925_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.577e-80
NZ_CP048406.1\|WP_082982365.1\|4126429_4127140_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.39308e-33
NZ_CP048406.1\|WP_156768324.1\|4120437_4121925_+\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173868	cd08503, PBP2_NikA_DppA_OppA_like_17, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP048406.1\|WP_065008239.1\|4129149_4129947_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	9.61409e-42

>NZ_CP048406.1|WP_065008239.1|4129149_4129947_-|response-regulator-transcription-factor
MMTRQSFITVLVGPSELLREGLSRILDAANFRILFSAACVHDLLQKPLPQHRPILLIIDVGGIDADAEFAQIADFKAIYPTCHVVALADYCRTTDIVSALRAGADGYLTKAAAYDTFVKALELVMLGQMVLPAETSTFLQDVRHGLKHATVTDELTHMAVKVENEDRELVILSNRERCILWRLIEGESNKAIAREINIAEATVKVHVKAILRKIRVRNRTQAAVWAMNHGMLTPPSGNGSSGNDKMATQQSHHPQDLLKALKGYH
>NZ_CP048406.1|WP_065008240.1|4128684_4128882_-|hypothetical-protein
MLEYEIPNRKRDQLVAVLTQIDEEAYSTKGKWFLETGFGLLSGQNFGTIEEAIGWVGRHTFPEPA
>NZ_CP048406.1|WP_082982364.1|4127793_4128582_+|response-regulator-transcription-factor
MGKSGYSTARLHNYTSANRSGVPSSGSVHGQREYLLILDGRALDRECLASALVDHELGMGVAALSSIDEWRVKKGSAPPLAAILFNLGGRKVTDHGIADEIRHISSEFKSIPVVILADTEDLVQILTALECGARGYIPTSVGIDVCVEAINLAAAGGIFVPASSVLSMRHLMDSGSRDRQPLTGIFTLRQAEVAQALRRGKANKIIAYELNLRESTVKVHIRNIMKKLKATNRTEVAYKVNDLLAEGTLVEEWTRHNTARLG
>NZ_CP048406.1|WP_082982365.1|4126429_4127140_+|Crp/Fnr-family-transcriptional-regulator
MQTLLEFMRSHPVGGTLSKNGRGNNDFFGVTAKIYKPHSVISRQDDHNDGIFVVKSGWAILYHGLPDGERQIIDTPLKGDIVGFRGVDGPRLASLASITELAVYEISSKELLKAILSQGHLGKKIACSLARLNAILAEHLMNTGRRNAMRRTAHFLLELEERLSMVGLSAHGRYECPLTQYELADILGMTAVHVNRTLRELRKADLVSFKSGYVEVINRKKLVETAGFDSEYLRYL
>NZ_CP048406.1|WP_065008242.1|4125836_4126070_-|hypothetical-protein
MANLHDRQPIILDPAAYDAWLDAATPTSAAKDLLRRDLGGQLQFNRVDRQVNLSKNKGGEELIQPIDMASEYGPFPR
>NZ_CP048406.1|WP_065008243.1|4123914_4125567_+|ABC-transporter-ATP-binding-protein
MKSKVSGLREKGTKLLSIRDLHVEGFSDERWHPIVRGVDLSLRRGEVLGLIGESGAGKSTIGLAAMGYAKPGCRITQGSILFDGIDLLAMSETARRRLRGSRIAYVAQSAAASFNPAHRLLDQTVETVVAHGIASREAANRDAIELYRRLHLPDPDTIGFRYPHQVSGGQLQRAMTAMAMACRPDLIIFDEPTTALDVTTQVEVLASIRKIVEDFNTAAIYVTHDLAVVAQMADRIMVLRHGRTVEEAETRQMLAAPTEDYTRTLWAVRKLAKPEVPAADHLLTIDNITAAYAGAVKVLQDVSIKVPLGRTVAVVGESGSGKSTLARVITGLLPPVSGSISFAGHRLPKTLKERPRDILRRIQMIYQMPDNALNPRQTVEEIISRPLEFYLGLKGAACDRRVGELMHMIEMDESFRDRLPGELSGGQKQRICIARALAANPELIICDEVTSALDQIVQEEILKLLMRLQQEFGVSYIFITHDIATVRAIADEIVVMHQGKVVEQGLKTEILTPPHAPYTELLLSSVPEVDPDWLTKLLETRERKRVGAAN
>NZ_CP048406.1|WP_029353914.1|4123040_4123925_+|ABC-transporter-permease
MTSTEHVVAVPRQRRTRASRVKTALKKAPFSAWFGVVVILGYVFVALLAPWIAPYGETQVFTEAFAPWSQEFIVGTDQLGRDVLTRLIYGARNTIGIAFATTLLSFAVGVTLGLLAAMYRGWLDQILSRAVDVLMSIPSLIFALMLLSIFGSSVTNLILIIALLDSTRVFRLARAVGLNVAVMEYVEAAQLRGEGPRWILTKEILPNVLPPLIAEFGLRFCFVFLTIAALSFLGVGIQPPTADWGSMVRENATLITYGDITPLLPAGAIALLTVSVNFVVDWFLHATSGLRDEK
>NZ_CP048406.1|WP_065008244.1|4121997_4123044_+|ABC-transporter-permease
MNPVVRTVLQRLGLGLITLFIVSIIIFSAIAMLPGDFAKAMLGQSATPGTVAAFQREIGIDRPPVERYFAWVGQIVQGDFGSSFASRTGYRRTVAEIIAPRLYNTMFLAVMTALIAVPLALGLGILAALYRNSWFDRVVNTVTLTTISFPEFFVAYMLAYLIISRDTFIGTEFAQSLPEWLAASINWVLNLVPKFPTLANISDRTPFWEHVWRAALPSITLTLVIVAHMMRMTRAAIINMLASPYIDMARLKGMSPMAIVLRHALPNAWAPIVTVIAFNLAYLIVGVVVVEVVFVYPGIGQLMVDAVKSRDVPVVQACALIFAATYILLNLTADIISIATNPRLLHPR
>NZ_CP048406.1|WP_156768324.1|4120437_4121925_+|peptide-ABC-transporter-substrate-binding-protein
MLFVSVARAAPKQGGFAKLGMAHGATTDSIDPAGYPDTFTQTAFSGAMSNSLTEVDAKGSIQPDLAESFETSDEATTWVFKLRKGATFHNGKTITADDVVASMQYHMGADTKSAAKSLLESVTNIKADGPETIVFTLNSGNADFPYIMSDYHLVVMPAKNGKADWESGVRTGAFVLENFQPGVSAKLKRNPNYFKAGKPYLDEVEFIAITDLAARMAALSTGEVDYIGRADLKTLGMLKRKPNIDILEVTGYGHYTLPMNVTVAPFDNPDVRMALKWAIDREEIAQKIFLGHATVGNDNPIAPAIKFAINPEPQHKFDPEKARFHLKKAGMENLKVDLSVADAAFAGAVDAAALIRETAAQCGIDVNVVREAEDAYWDNIWLKKPWCASYWSGRATADWMFTQAYSADSSWNETFWKNPRFNELLIQARAETDEARRSAMYAEMQQLTHDDGGAIVLVFNNFVSAKSKKLAHGELAPNWENDGLKMAERWWEANA
>NZ_CP048406.1|WP_065008246.1|4119849_4120203_+|Rieske-(2Fe-2S)-protein
MAEKTYICRVDEIETGTPYIAKIRSLSVGIFRIGDSFHALLNVCPHRGAPLCEGPQCGTTAPVDQAQFIYHRENEIVRCAWHGWEFDIKTGAALVDPGVRARTFPVTVEAGEIYVTA
>NZ_CP048406.1|WP_163603052.1|4132495_4133656_-|FAD-dependent-monooxygenase
MNNIDVAVLGGGTAGSLAAAMLGRMGISTILVDIHPVYPVEFRCEKLDGDQVDLLKKTGLVDDVLAAATPMAEIWVARRGYVIGKKQGKHGEPCEYGVAYEDLVNVIRRQIPDSVQFICAKVTKITTSSDRQEITLSNGDTWSTRLIVVATGLNNVVRGAITRSEISKCHSISVGFDLTSKAGFKFQALTYSAERPGPMGYVSMFPIGSRMRANVFVYHGDIRHPWCQEVRTSPLSALYSVMPRLKRLLGDAVVSSDIQIRPVDLYAAQNHEQQPGLVLAGDSFATSDPAAGTGLNKVLTDVDRLCHHIPTWLATPGMGIEKIQTYYRDPVKVACDEWSLGEAFYNRSLASDTTLLWRIRRMGWIGLDMMGISIPQLRLMAASAVR
>NZ_CP048406.1|WP_156768313.1|4133648_4133999_-|NAD(P)-binding-protein
MYGVDIGTVGGGLAGSIAAATLGRAGFSVVLIDAHHPYPEDFRCETIEEKQFRLLRETGRLMENQGRLFIARPGQRCSPNCVFAAIDGVLNFLRHRLVRCHDRVVNEVVGEGAGIE
>NZ_CP048406.1|WP_082982360.1|4134095_4135358_-|GNAT-family-N-acetyltransferase
MALGLGFQAEHSLAAGLAKTFVTLEHPMTTANIALQIFTDMDAVEAQWRTLEQHADCTVFQLFDWQMEWYRHIGSKEKLIPVIVLGLDDTGVAVFILPLAIERHGLIRRLVWFGSELCDYNSPILATNFSDHVKPGQFGRLWKDIIRTIQDYPQLRFDAVEFYNMPSVVGSQPNPFLDLPVLLTNCGGHVATLPEANWDRFYASKFSNSTLHTHRRKAKNLAKRGGGSIRFVDVQEQAEIECTITKLIEQKRSSYARMGVHDMFARPGFREFYLAIVANPRLCEVIHVTRLDVAGIPVATGLGLRFNSIYSLVMSSYEDEFAKYSPGRQHIQEMMQYAIAQKMQKFDFTIGDEPYKLAWSDINLPLFFHFDSRNLRGRIVIAVRMAIHYVDTWYAKTTLLNPPLRQVLRKTRRSLRRMFI
>NZ_CP048406.1|WP_156768312.1|4135371_4136709_-|hypothetical-protein
MPVDLVRTAIIRARRELRKSAALVLNSSALAIGTIAAAGLGFVYWWLAARLFPPEVIGKAAALLSVMAFVGLLGEGGLGTLLMGEIVRHPGRDRGLVAAAASIGVVLGVGLAVVFVFGDAYLNSSTESIGGWLQRVAFVLGCGLTVLAMMVDQAFVGNLRSTGRMIRQVLFSTFKLLLIACAAAAGHTSSAALLLTWVAGLLASFVGVDLLTRGGARRLVGVPDFRLLHILRRKVVDHYALDVAVQAPSVIMPYLVLVLLSPTTNAAFVALWMLVSMASLIPAAMATVLFPVIRACPKQSRHDVLVSVTASLLFSLVCAVIVFTYSQQILAVFNPAYPEIAGSSLRFLGFSLLGSTLKFHACTLARLGDRMRKASRWFALGGLLELCFVVAGAKLGGLQGLVLGWTLAVSIEGACAALILAFAVKLDSAAGPAQHERPTESPLQT
>NZ_CP048406.1|WP_082982359.1|4136699_4137980_-|glycosyltransferase-family-4-protein
MRILLLSQFYPPVIGGEERHVRNLGAALAQRGHHVSVGTLMHPGSPETELDGAVRVHRLRGTLQRLSGLHSDPERRHAPPFPDPELVLALKRLVAREEPDIVHAHNWIYASFLPLKGLSGARLVVTLHDYGLVCAKKNFMHLGANLCSGPAPAKCLPCATRHYGAVKAAATTFGNWASSFAARRAVDRFIAVSHAVARHTGLTEGSAPYEVIPNFVPDDVGVLGPENPCLRELPRDEFILFVGDMMRLKGIDVLLRAYAGLERAPQLVLIGRRVADTPTEFPPNVRVFSAWPHSAIMHAWRRSLYGVLPSVGPEACATVIMEAMASGKAVVATGVGGMPDLVDHGETGLLVPPGDAHALSHAMQTLLENRALLARLEVTSLARVGRLKAGAVVTRIEQVYRDVLRPAASRAAVPSQQGSSGEPSCR
>NZ_CP048406.1|WP_156768311.1|4137994_4138639_-|hypothetical-protein
MVLLVPGHTVLRAIGIRTTSALQHLVYAVGASFAAGIAGGFALNAAGLLTPLGWALWFWAVTAAAAVVAAGRCDTPDLPAWPAPARVRLWQVAALMLAVLVATGAYALAVRDEAAYREFKYIAFWLLPSASGQSGRITVGIRSAETRPQRFDVEITLDGQPFAVFRSIAVPPGHTWTREISVSALATRQTAEARLYRPKDNRLYRSVSTLVPRI
>NZ_CP048406.1|WP_163603053.1|4138739_4140719_-|hypothetical-protein
MMLMMPAHFTAGTRINPLQAGIRFVSAVIGPDLRGGSADTPPQRANSGWIAVLCLTVATALLLVVAGHAAGRRGYDVAPLLFWPGIVLLVAPTSLRIAWPTTARGERLFLLFLLAEALFYCKVVYSPTSFSGYDEVLHWIAAEDLITARRLFLSNPLFPIGPTYPALEILTTAIVDLTGLPLFVAGTLLLAILKGTFIGALFLFLESIAGSPRISAIACLAYMGCSTFFLFDSMFSYGSLGIVLCVLTFAVEAASKDLVGRPRLKSLGLIALLLASLAVTHHLSAAFAAIYFGALAALEALRRHEPLRNKTSIAVGVAAILAIALPSLWVQARGIPLTGYLGPVIESGFDTLLGKILGAPTPRSEHLGAPDKALYMRLTTLLALLLVALGLATGFFRSLAMAAPGGARSRWRPIQNILKRRWSDSRLVLLSLLAFGLPVSVAFRLTVAGWEIGNRMATFVFIAVGLVVAVSIVHFWQGRTPRGWRRIAPAVALVIIVLGGVTSSSINPIHGRFRVAADQESIEPMGIETARWAKEWLGAGNRFTTDRINRLLLASYGRQDVRVTIIEGIDPARIFEAETLGPDEYWALAGSDIDFLLIDLRLTTAPPVLGFYFQPWQAQRGTPLLGAALLKFNDVKGITRIYDNGWIVIYDVRGLHENS
>NZ_CP048406.1|WP_065008233.1|4140715_4141861_-|glycosyltransferase-family-4-protein
MRILMVAARCYPLIGGIETHIQEVGPRLVARGHSVDVLSTDPSGELPVEEEVRGMRVRRVRAWPRELDLYAAPGIYTAIRRGVWDLIHFQGYNSFVAPIGLLAAIRGDLPFILTFHSGGHSSRLRNAVRGTQHALLRPLVARAARLIGVSEFEADFFSVRMGLPRERFVVIPNGAAMPAASPGVKVDPNLIVSGGRLERYKGHHRAIAALPELIRRVPDVRLHIVGTGPYEGELRRLVATHGLEKRVTIGGIPGSERQKMADLLASAALFVLFSDYEAHPVAVMEALSLRRPVLVSDTSGLRELAANGLCRAIPPDAGPKELAAAMAEELRAHREVPGMALPDWDACAQALNDVYCEVLSSRSMVRLPSGGVTSWPPATRA
>NZ_CP048406.1|WP_156768309.1|4141848_4142667_-|glycosyltransferase
MNAPLSSILAPVGATSPPDPVNFALRRSVTLPRVSFVVPTLNEAKNLPWLLPRIPNWAHEIIIVDGRSTDDTVAVARRLREDVKVVMEPRRGKGAALQAGFLAATGDIIVMLDADGSMVPEEAIVFVSALMAGADLVKGSRFIQGAGTHDMSLFRMFGNKGLTLFVRLLFGGWFSDLCYGYIAFWSKHVATLDCDCDGFEIETLINVRALKNHLNIVEVASFEVPRISGVSHLRAIPDGWRILKTILRERVQPQQRRSATACDVGGQTRCES
>NZ_CP048406.1|WP_065008231.1|4143334_4144990_-|hypothetical-protein
MRICLSLDPSRLLRWHLWLTEALAEVPGNEVSCALAAGSRPLPLICRLLLELERLVYGFRGYGAIDPVEAALRCLPPPQADQVDVVIDLSGAESLPAARRVLTPVFNGAPGEIGVVAAWLNHQDLLVDLHDTARPLRPWTARPASGDREVLATRLDSALSCAVPLILKALYEETGSSASGIPGPRMAVPSFGALSALARATGTVASKAIGLLDVLARGGRMWGIGWRFDESASLLDKGEAAFRVFTGNADSYLADPFPFRHQGQDFIFVEQYLYSKNRGCIAVVTVNRDGTAGASRIVVEEPHHLSYPFVFEQDGQTWMIPESGAARNVSLYRAVEFPYRWTREACLMEGIEGYDTTPFWHAGGFWFFVSPRLWRSTSWDVLSLYRAESLTGSWTSHAANPVLLDARLSRPAGAVIRHGGRTLRPVQDCARVYGGAVTFCQIDALGASEFAQTPVGRIWSGALGCHTYNRRSGLEVIDLFGHIRGLREVTTSYRLLVPDAPVSGPREVSGPRGQSLSWPVSSGLATRSQAVEREVPRLRRAGHARPFSATE

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Crispr_ID: NZ_CP048406_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_5

5653261-5653361

Orphan

Consensus_repeat	Method
CATCAGATTTTCACCACTAGAAATCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048406_5

>merge|NZ_CP048406|5|5653261-5653361|CRISPRCasFinder
CATCAGATTTTCACCACTAGAAATCGAGCGAGCGTTCGTTTTCCTTATTCGCCTCTATCCCTTTTTGCAGCCGCCATCAGATTTTCACCACAAGAAATCGA

>NZ_CP048406|5|5|5653261-5653361|CRISPRCasFinder
CATCAGATTTTCACCACTAGAAATCGA	GCGAGCGTTCGTTTTCCTTATTCGCCTCTATCCCTTTTTGCAGCCGC
CATCAGATTTTCACCACAAGAAATCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_065007093.1\|5644845_5645304_+\|dehydratase	unknown	unknown	gnl\|CDD\|239530
NZ_CP048406.1\|WP_065007080.1\|5660741_5661794_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225052
NZ_CP048406.1\|WP_065007082.1\|5657538_5658210_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP048406.1\|WP_065007089.1\|5649590_5649896_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065007146.1\|5654685_5655633_-\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|235706
NZ_CP048406.1\|WP_065007083.1\|5656706_5657300_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|259892
NZ_CP048406.1\|WP_065007092.1\|5646765_5647419_-\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|226344
NZ_CP048406.1\|WP_065007086.1\|5652435_5652885_-\|lipocalin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|372819
NZ_CP048406.1\|WP_127208532.1\|5649973_5650999_-\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NZ_CP048406.1\|WP_065007147.1\|5645603_5646698_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|238527
NZ_CP048406.1\|WP_065007084.1\|5653726_5654689_-\|3-keto-5-aminohexanoate-cleavage-protein	unknown	unknown	gnl\|CDD\|377562
NZ_CP048406.1\|WP_065007091.1\|5647459_5648680_-\|DNA-binding-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065007094.1\|5643767_5644844_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP048406.1\|WP_065007090.1\|5648813_5649584_+\|DUF899-domain-containing-protein	unknown	unknown	gnl\|CDD\|377584
NZ_CP048406.1\|WP_065007081.1\|5658936_5660745_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|214900
NZ_CP048406.1\|WP_065007087.1\|5651034_5652246_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173844
NZ_CP048406.1\|WP_065007079.1\|5661790_5663266_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143432
NZ_CP048406.1\|WP_065007144.1\|5658356_5658944_+\|amino-acid-synthesis-family-protein	unknown	unknown	gnl\|CDD\|369036
NZ_CP048406.1\|WP_065007078.1\|5663331_5664336_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270307
NZ_CP048406.1\|WP_065007145.1\|5655643_5656465_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|183778

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_065007093.1\|5644845_5645304_+\|dehydratase	gnl\|CDD\|239530	cd03446, MaoC_like, MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.	3.66908e-49
NZ_CP048406.1\|WP_065007080.1\|5660741_5661794_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	3.24275e-63
NZ_CP048406.1\|WP_065007082.1\|5657538_5658210_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.32893e-37
NZ_CP048406.1\|WP_065007145.1\|5655643_5656465_-\|SDR-family-oxidoreductase	gnl\|CDD\|183778	PRK12829, PRK12829, short chain dehydrogenase; Provisional.	3.42243e-106
NZ_CP048406.1\|WP_065007146.1\|5654685_5655633_-\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|235706	PRK06129, PRK06129, 3-hydroxyacyl-CoA dehydrogenase; Validated.	1.44726e-178
NZ_CP048406.1\|WP_065007083.1\|5656706_5657300_-\|hypothetical-protein	gnl\|CDD\|259892	cd04230, Sulfocyanin, Sulfocyanin is a blue copper protein in archaebacterium Sulfolobus acidocaldarius. Sulfocyanin is a blue copper protein with a putative membrane anchoring hydrophobic motif at the N-terminus. It may substitute for cytochrome C in electron transfer reactions in archaea.	3.78954e-06
NZ_CP048406.1\|WP_065007092.1\|5646765_5647419_-\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|226344	COG3823, COG3823, Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones].	9.31566e-07
NZ_CP048406.1\|WP_065007086.1\|5652435_5652885_-\|lipocalin-like-domain-containing-protein	gnl\|CDD\|372819	pfam13924, Lipocalin_5, Lipocalin-like domain. This family includes domains distantly related to lipocalins. However, they do contain the important GXW motif in the first strand. The protein in this family include aln5, which is involved in biosynthesis of alnumycin. The family also includes the ZFK protein from Trypanosoma brucei which is a protein kinase. This domain is at the C-terminus of that protein. The domain is also found as the C-terminal domain in StiJ a protein involved in producing stigmatellin. This domain has been assumed to catalyze a final cyclisation reaction.	3.16657e-37
NZ_CP048406.1\|WP_127208532.1\|5649973_5650999_-\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.29674e-99
NZ_CP048406.1\|WP_065007147.1\|5645603_5646698_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|238527	cd01094, Alkanesulfonate_monoxygenase, Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).	9.94829e-70
NZ_CP048406.1\|WP_065007084.1\|5653726_5654689_-\|3-keto-5-aminohexanoate-cleavage-protein	gnl\|CDD\|377562	pfam05853, BKACE, beta-keto acid cleavage enzyme. BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyzes the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA. The family is found to have at least 14 slightly different potential new enzymatic activities, all of which can therefore be designated as beta-keto acid cleavage enzymes.	1.66984e-143
NZ_CP048406.1\|WP_065007094.1\|5643767_5644844_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.21284e-49
NZ_CP048406.1\|WP_065007090.1\|5648813_5649584_+\|DUF899-domain-containing-protein	gnl\|CDD\|377584	pfam05988, DUF899, Bacterial protein of unknown function (DUF899). This family consists of several uncharacterized bacterial proteins of unknown function.	1.08436e-122
NZ_CP048406.1\|WP_065007081.1\|5658936_5660745_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	2.56537e-49
NZ_CP048406.1\|WP_065007087.1\|5651034_5652246_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	5.45846e-106
NZ_CP048406.1\|WP_065007079.1\|5661790_5663266_+\|aldehyde-dehydrogenase	gnl\|CDD\|143432	cd07114, ALDH_DhaS, Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like. Uncharacterized aldehyde dehydrogenase from Candidatus pelagibacter (DhaS) and other related sequences are present in this CD.	0
NZ_CP048406.1\|WP_065007144.1\|5658356_5658944_+\|amino-acid-synthesis-family-protein	gnl\|CDD\|369036	pfam06684, AA_synth, Amino acid synthesis. This family of proteins is structurally similar to proteins with the Bacillus chorismate mutase-like (BCM-like) fold. This structure, combined with its genomic context, suggest that it has a role in amino acid synthesis.	3.25867e-84
NZ_CP048406.1\|WP_065007078.1\|5663331_5664336_+\|extracellular-solute-binding-protein	gnl\|CDD\|270307	cd13589, PBP2_polyamine_RpCGA009, The periplasmic-binding component of an uncharacterized ABC transport system from Rhodopseudomonas palustris CGA009 and related proteins; contains the type 2 periplasmic-binding fold. This group represents the periplasmic binding domain that serves as the primary high-affinity receptor of an uncharacterized ABC-type polyamine transporter from Rhodopseudomonas palustris Cga009 and related proteins from other bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.4836e-89

>NZ_CP048406.1|WP_065007086.1|5652435_5652885_-|lipocalin-like-domain-containing-protein
MSQLKTLLLGSWRMTSWVYEILETGEVLDALGQNPRGIISYSADGRMMVFVLRTDRSTPAALVPTSNEKIALYDSMFAYAGTYSVEHDRIVHHIDMSWNQSWEGTEQVRYLETDGRTLLYRSAPAQNPLDGKDCVHTVRFEKITSTSSH
>NZ_CP048406.1|WP_065007087.1|5651034_5652246_-|acyl-CoA-dehydrogenase
MNFDIPAQTEDYRVRIADFVEREILPLEADNMSYDAHGNITLPLLEALRAKARMAGLWCLQLKPESGGAGLGKMDMAVCYEEMNRSIFGPVVFNSAAPDDGNMMVLEALGTPAQKQKWLKPIVEGKVRSAFAMTEPHPGGGSDPSMIMTRAKRRGDKYVVTGRKWFITGAEEASHFILIARTSDDPRHGLSALMFHKDQPGWRIMRRIEIMGPEEHGGHCELEFDGLEIPVEDMLVGEGRGMKVTQVRLGPARLTHCMRWLGLSRRCVEIARAYAAERHGFGQRLADRESVQLKLGDLAMRIEIGRILVMKAAWELDRGGFARKEVSMAKVQVANVLHDAADVAIQINGARGYSKDTVLEWIYRYARQARLVDGADEVHKMVLNRFLNEEERGFWRWTVEGEA
>NZ_CP048406.1|WP_127208532.1|5649973_5650999_-|phosphotransferase-family-protein
MNADFDPAALKGFLASRFGDASMSLGRIGGGQSNPTYFVDYGAHRMVLRKKPAGPILRGAHAVDREFRVLEALAPTNVPVPGPVLYHDGAELLGTPFYLMERLDGRIFHDCSLPGLSPAQRRGIYFGMAEAMAKLHAVRPDEVGLGDYGRPGNYFERQIGRWTRQLRESPSDRIPALEAVADWLPQHMPVDDGRLSIAHGDFRLGNLLFHPDKPQVIGILDWELSTIGHPLADLGFCSMTWHSAPDEYGGILGLDHEALGIPSQREFLDHYFAHAVPTAPLQRFHLVFSLFRFAVIFVGIADRARAGSAASADAAGKWPLAGRFAVRAQEIIQGARPWSAA
>NZ_CP048406.1|WP_065007089.1|5649590_5649896_+|hypothetical-protein
MTLHSNDTQKMPPAGSGSADFPSDNVAARGAADWLSLAAAPTFAMMALQTAVAGGADMICSAAQDASPLSGMVMMYLLMSAFHLAPWLKLVASRRSAVRRS
>NZ_CP048406.1|WP_065007090.1|5648813_5649584_+|DUF899-domain-containing-protein
MPTHRTGTREEWLAARLDLLKAEKELTRQSDEVARRRQELSWVRIDKDYRFETDEGSASLADLFQGRSQLLVYHFMFGPDYTAGCPACSAIADGFDGFVIHLANHDVTLSAVSRAPLGKLKAYKRRMGWTFPWASSHGGDFNFDFDVSFTEEQQREEGIDYNYVREAPLAEIPSRTTADGSETFAAMSGTDMATYTRERPGMSTFVLEDGVVYHAYSTYARGLDGLWGMYQWLDRAPRGRNETGVWWRRHDEYGQG
>NZ_CP048406.1|WP_065007091.1|5647459_5648680_-|DNA-binding-protein
MDSLITAAARALATGDPLGALKRVALRDDAPALALRGIAMAQLGDLVRAKALLKSAARAFGPKEAVARARCVVAEAEIALVSRDLGWPAKALDAARATLEKHGDRFNAAHARNLEVRRLLLIGRLDEAERRLAGFDPTPLPPASRAAHELVIAGIAIRRLRTKAARAALARAEHAAREADIPALTAEVESASLVMNTPAARLIARGEERPLLLEEVEALLASGALVVDACRNIVRDAGMIVPLATRPVLFALARTLGEAWPADVPRSTLVARAFGGKHADESHRARLRVEVGRLRAELRSLADVSATKRGFALKPRRPRDVVVLAPPVDEQHAAVLAFLADGESWSSSALAIALGASSRTVQRSLEQLAAAGKVQSFGRGRARRWMTPPVPGFPTILLLPGSLSGY
>NZ_CP048406.1|WP_065007092.1|5646765_5647419_-|PQQ-binding-like-beta-propeller-repeat-protein
MKRSAAEVLREYGPFPGVDQVAGVTFDGQHVWFASGDRLNALDHASGKVVRAIEVAAHAGTAFDGQHLFQIAEDRIQKIDPNTGRVLATIPAPGGGGDSGLAWAEGSLWVGQNRGRKIHQIDPQTGAVLRTIDSNRIVTGVTWIDGELWHGTWEGDESDVRRIDPETGKVLEKLDMPPGTGVSGLESDGGDQFFCGGGNSGKVRAIRRPRRGSEERS
>NZ_CP048406.1|WP_065007147.1|5645603_5646698_-|LLM-class-flavin-dependent-oxidoreductase
MRKQHPLKGPNRFKLGVFSMNADGGLAMTTVPERWRARWEDNLNAACIADRAGLEFLLPIARWRGFGGLTHVREWSFETFTWAAGLAVATENIGLFMTVHVPLVHPLQAAKALATVDHISNGRAGLNIVCGWNPDEFAMFGQTVGDRTYDQAEEWINIIERAYQSREPFDFGGEFYDLKGVVSRPPSLQAPRPVTMNAAFGAPGRNYAARHCDYLFSTFSEIADGRAHVVDITNRAAEVGREVGVYTVCHVVCRETQQEAEDYYRHYALECADEGAVDEHMRKKKEFANSHDAKAFTEYRQRFAGGAGTFPLIGTPEKIVDDLTEIMDQGYSGAALTFVNYTYELPFFCDRVLPLMRQAGLRVN
>NZ_CP048406.1|WP_065007093.1|5644845_5645304_+|dehydratase
MEQTVYFEDYQIGSSRMTSGRTITETDFVVHAGHTGDFFPHHMDAEFMKTTPFGQRIAHGTLVFSVGVGLTASVINPVAFSYGYDRLRFIKPVFIGDTIKTRTTISAKEDDPKRPDSGRVIERCEVINQHGDVVLAADHIYIVERRDKPEPG
>NZ_CP048406.1|WP_065007094.1|5643767_5644844_+|Gfo/Idh/MocA-family-oxidoreductase
MTDGAFDPDSLSQSWAKPSKPRPIVIFGAGSIAGDAHFPAYGKAGFPVAGLFDPDHTKAERLAQKWGVATYRSVGEAAAIKDAVFDLATPPAHHAGVLRALPDGAVALIQKPMGSDLSEATEILEICRSKKLKAAVNFQLRFAPMMLALKDAIAKGWLGDVVDFDAWLALATPWQLWEFLVKAPRVEIAMHSIHYLDLIRQLLGDPRGVHAKTLGHPGHKVAQTRTSAILDYGGTVRCALSINHDHKFGRKHQACEFRICGTEGAAYLKLGLNLDYPRGEPDILEIYPKGGSDWVAVPLIGQWFPDAFVGRMANVHRYASGEDTELVSSVEDGWNTMALVEAAYQSSAAPATPIAARP
>NZ_CP048406.1|WP_065007084.1|5653726_5654689_-|3-keto-5-aminohexanoate-cleavage-protein
MTETSRKPGAQLPKGKVIITCAVTGAIHTPTMSPYLPITPDQIAAEAIAAAEAGAAILHLHARDPETGKPDQTPAAFARFLPRIKQATNAAINITTGGSPYMKVEERVRPAAEFKPEVASLNMGSINFGLYHLVDKYETFKFDWEKPHLEATRDLVFRNSFKDIEYILATCYDNGTRFEFECYDIAHLYNLSHFADRGLVKPPFFVQSVFGLLGGIGTHPEDVAHMKRTADRLFGDQFRWSVLGAGASQLRIAAQSAALGGNIRVGLEDSLWAGKGKLAKSNAEQVVLARKIIEGLGMEVATPDEAREILSLKGGDKVEF
>NZ_CP048406.1|WP_065007146.1|5654685_5655633_-|3-hydroxyacyl-CoA-dehydrogenase
MMKVAIVGSGFIGRAWAISFARAGHDVRMWDQSPAATAGAHDYIAGVLGDLAANDLLRGQAIDAVLDRIAVVAELGEALTDAVHIQENTPENLEVKREVFSLIDALAGPHAVIASSTSALLPSKFTDHLQGRHRCVVVHPINPPYLIPAAEVVPAPWTSPETVERTRAFLVAAGHAPLVMKHELDGFIMNRLQGALLEEAFRLVADGFASVEDVDIGIRDGLALRWSFMGPFETIDLNAPGGVRDYVERYQTIYSNIFPQMLRRVDWAGEVIETVEADRRKRLPREELVERQVWRDRRLMALAAHKKKSDQEFGR
>NZ_CP048406.1|WP_065007145.1|5655643_5656465_-|SDR-family-oxidoreductase
MSATAISKGAPTSADDFLTGLKGQRVLVTAGAGGIGLAIADTLSRLGARIVVCDVSDGALAAAPDKIALVAAVKADVSREDDVDRLFETVKQKLGGLDALINNAGIAGPTGGVDEIDPADWRRCIDICLTGQFLCARRAVPLIKAAGGGSIVSMSSAAGRHGYAFRTPYSAAKFGVIGFTQSLAKELGPHGIRVNAILPGIIEGPRIDKVIADRARQLGVSNEEMTQRYLQNISLRRMTSPYDVAAMVAFLLSDAGINISGQSLGVDGNVETL
>NZ_CP048406.1|WP_065007083.1|5656706_5657300_-|hypothetical-protein
MAMARFAHLALLAVALALLPGIALAGEPFVPSWIKNDPAAKTVAIEIVADWNQVERYRRDNIRTDIIDFNGYWGGNLTIVVPAEWSVEIEFINGSSSFRHSLMVTRVYAQSEMPVELTAEDAIWGVYTDPPEGIKINERRQLNFVAQQAGNYFLACARQTHLMDGHWIGFEVRDSIKQAVAIIDETNFPQEQPPGRP
>NZ_CP048406.1|WP_065007082.1|5657538_5658210_-|GntR-family-transcriptional-regulator
MADDTLRIERSTKTLRTLALERMRDAIMGFHFQPGERLVERPLCDQLGVSRSVVREVLRQLETEGLVQMIPGHGPAVARPDLSRTDEIYELRALMEGIAARACALTATQDQIAALEGALNVLLTAWASANPIEVMRATTKFYEVLFDAADKRIAWEIVQGLNVRINQLRSMTIASVNRRDAAIAEMTDIMNAIKSRNGDDAEAAARRHVEQAWRIAQQTLRHS
>NZ_CP048406.1|WP_065007144.1|5658356_5658944_+|amino-acid-synthesis-family-protein
MKPAIRKIVTYVENTLIEGGKVAPRALRLIGVAAVLDNPWAGRGFIEDLSPEIRAYAPVLGEMLTHEILAVAGSGEAIEGYGKAAICGTSGEIEHASALIHTLHFGNHYRRAVGAKTYLAFTNLRGGPNTPIMIPLMDKNDEGRRSHYLTVHFQIGDAPAPDELVVALGASIGGRPHHRIGDRYQDLKEVGDLHG
>NZ_CP048406.1|WP_065007081.1|5658936_5660745_+|alpha/beta-fold-hydrolase
MAELTAPGWHRGTAPDGTGFIRAGSGAPVLLIHGVGMNAAVWGPQIELMKDRWDVIAIDMLGHGRSPLPPEDASLADYAGQAIRLLDHLGLGAVSIVGHSMGALVGQEIALDAPERVRSIVSLNAVFRRPAALAQAVRERAAELNGAKNPSGTDATIARWFGNPVPDSLAEAARTTRAALQSVNREGYARTYRLFAHADAAHGDRLSGLAVPALFMTGSQDRNSSPAMSAAMARLAPRGRCVVLEGERHMMAIASPDAVTRRIVDFLESNDSTSTSGRPAMNTAFDAGEFRRALGSFLTGVTIVTAIGPEGEPRGFTANSFTSVSLDPPLVLVCIAKKALGYPVFSTSKCFAINVLSEEQRAASGVFASKSQDKFSAVEWRFGPTGSPLLGGSVATFDCDMEQLVDAGDHSILIGRVREFSHNSSQPLGYCRGAYVSPGLSQEALAAAPPDMEVGAILEDEGRVLFFETVDGFFELPAGRGLGTSGDTRSLNGRLAAQAIEAHLGFLFAVWDDAASPSRTHVYYRGTVDTPHSSNGQVQLVDIDRIAGLNIADAAVRSMLARYVRECREDAFGVYVGNEVEGEVRPLAKPAPMNTSNPGEQI
>NZ_CP048406.1|WP_065007080.1|5660741_5661794_+|LLM-class-flavin-dependent-oxidoreductase
MKFSLFVHMERSDSAKPHAELIDELEELVLMAEAAGFETAWIGEHHGMEFTISPNPFINIAYLGARTKRIRLGTGTVVAPFWHPIKLAGEAAMTDVVTGGRLDIGIARGAYSYEYQRLFPGLDAWGAGQRMREIIPAIQGLWQGDFETSGEFWSFPSTTSSPKPVQKPHPPIWVAARDPNSHDFAVSNGCNVQVTPLASGDDEVTSLMERFNAACAAHPDMARPDIMLLMHTFVAEDAADAEQLTKDLSLFYCQFGAWFQNKKPVRQGILEALTDDEIAAMPQYAPDKIRQHLVIGEAEEVIARLKAYEALGYDQYSIWIDSGLPHERKKKSLQLFVDKVMPAFRHGRPQ
>NZ_CP048406.1|WP_065007079.1|5661790_5663266_+|aldehyde-dehydrogenase
MTLAAFRNFIDGAFDTPTATFESIDPSTGAPWATMPAATEADVDRAVEAAHRTLRSAAWTSLTATARGKLLVRLGELVVANARRLAELETRDTGKIIRETRAQIAYVGDYYRYYGGLADKHEGSHLPIDKADMDVTIRREPIGVVAAVVPWNSQLFLSAVKLGPALAAGCTVVLKASEDGPAPLLAFAELVHEAGFPAGSVNILTGFGHDCGRRLTSHPLVSRVAFTGGPSTARAVVRNTAENLAYTTLELGGKSPVVVFADADLDSTANAVVAGIFAASGQSCVAGSRLLVERSIKAEFLDRLKHKAEAIRIADPQDPATEMGPLATPRQREWIEKIVAESLAKGGTLVTGGKRPDDHPRGFYYAPTIIDAEDTGLPCVREELFGPVLSVLTFDTEAEALALANDTPFGLASGVFTTNLAKAHRMARDIHAGVVWVNTYRAVSPLVPFGGYGQSGLGREGGLDAIRDYTRSKSVWIRISDEPIPDPFVMR
>NZ_CP048406.1|WP_065007078.1|5663331_5664336_+|extracellular-solute-binding-protein
MKLILTGILAGFLAATAAHADEMVFTSWGGTTQEAQTKSWAAPFEASSGIKVLQDGPTNYGKLKAMVEGGSVAWDVVDVEMDFAIKAAKDGLLEPIDFNVVPKADLDPRFTTDHAVGSFYYSFVLAWNKGAVSGEPTGWADMFDLTKFPGKRTFYKWSAPGVIEIALLADGVPADKLYPLDLDRAFKKLDTIKSEIVWWDSGAQSQQLIASGEAAFGQLWNGRVFALKQDGADVGASWNQNMTAADVLVIPKGSKNKASAMKFLATATSPKSQAMFAEASGYAPINKAAKAEMPADVVKSLPDAYVDGQINLDMNYWAENRDTIAERWYAWQAK

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Crispr_ID: NZ_CP048406_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_8

6191163-6191320

TypeI

Consensus_repeat	Method
CCCTCTCACGGGGGCGTGGATCGAAA	PILER-CR

2 spacers

cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP048406_8

>merge|NZ_CP048406|8|6191163-6191320|PILER-CR
CCCTCTCACGGGGGCGTGGATCGAAACTCCTTCGGTGGGCAGGTTTTGCTGGCGTGGAAAAGGTCGCCCTCTCACGGGGCGTGGATCGAAAGGCCTTCGACGCCTTCAAGCTGCGCGTCATGCTGAGTCGCCCCTCTCACGGGGGGCGTGGATCGAAA

>NZ_CP048406|8|3|6191163-6191320|PILER-CR
CCCTCTCACGGGGGCGTGGATCGAAAC	TCCTTCGGTGGGCAGGTTTTGCTGGCGTGGAAAAGGTCGC
CCTCTCACGGGGCGTGGATCGAAAGGC	CTTCGACGCCTTCAAGCTGCGCGTCATGCTGAGTCGCCCC
TCTCACGGGGGGCGTGGATCGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_065008552.1\|6178342_6179308_-\|toll/interleukin-1-receptor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379328
NZ_CP048406.1\|WP_156768530.1\|6207449_6207617_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_082982395.1\|6180190_6180880_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|377306
NZ_CP048406.1\|WP_065008541.1\|6200033_6201182_-\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|223157
NZ_CP048406.1\|WP_065008525.1\|6179681_6180149_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008553.1\|6201416_6203198_-\|nif-specific-transcriptional-activator-NifA	unknown	unknown	gnl\|CDD\|273817
NZ_CP048406.1\|WP_065008540.1\|6198918_6199947_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225052
NZ_CP048406.1\|WP_065011499.1\|6205936_6207001_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380530
NZ_CP048406.1\|WP_065008530.1\|6187793_6188750_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NZ_CP048406.1\|WP_065008537.1\|6194244_6196491_-\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319846
NZ_CP048406.1\|WP_065008551.1\|6177067_6177718_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238154
NZ_CP048406.1\|WP_163603096.1\|6204355_6205654_+\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|234968
NZ_CP048406.1\|WP_065008529.1\|6186051_6187797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|378245
NZ_CP048406.1\|WP_065008539.1\|6197506_6198622_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP048406.1\|WP_065011504.1\|6208659_6209121_+\|transposase	unknown	unknown	gnl\|CDD\|366690
NZ_CP048406.1\|WP_065008527.1\|6183039_6185340_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_CP048406.1\|WP_065008528.1\|6185386_6186055_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NZ_CP048406.1\|WP_065008524.1\|6177868_6178339_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008538.1\|6196561_6196984_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|133412
NZ_CP048406.1\|WP_065008523.1\|6176114_6177071_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_065008552.1\|6178342_6179308_-\|toll/interleukin-1-receptor-domain-containing-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	3.25497e-14
NZ_CP048406.1\|WP_082982395.1\|6180190_6180880_-\|ATP-binding-protein	gnl\|CDD\|377306	pfam04326, AlbA_2, Putative DNA-binding domain. This family belongs to the AlbA clan of DNA-binding domains.	4.64389e-17
NZ_CP048406.1\|WP_065008541.1\|6200033_6201182_-\|histidinol-phosphate-transaminase	gnl\|CDD\|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	3.35024e-109
NZ_CP048406.1\|WP_065008553.1\|6201416_6203198_-\|nif-specific-transcriptional-activator-NifA	gnl\|CDD\|273817	TIGR01817, Nif-specific_regulatory_protein, Nif-specific regulatory protein. This model represents NifA, a DNA-binding regulatory protein for nitrogen fixation. The model produces scores between the trusted and noise cutoffs for a well-described NifA homolog in Aquifex aeolicus (which lacks nitrogenase), for transcriptional activators of alternative nitrogenases (VFe or FeFe instead of MoFe), and truncated forms. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, DNA interactions].	0
NZ_CP048406.1\|WP_065011499.1\|6205936_6207001_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|380530	cd06307, PBP1_sugar_binding, periplasmic sugar-binding domain of uncharacterized transport systems. Periplasmic sugar-binding domain of uncharacterized transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes.	6.49906e-90
NZ_CP048406.1\|WP_065011504.1\|6208659_6209121_+\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	7.6748e-07
NZ_CP048406.1\|WP_065008540.1\|6198918_6199947_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	5.04199e-44
NZ_CP048406.1\|WP_065008537.1\|6194244_6196491_-\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319846	cd07546, P-type_ATPase_Pb_Zn_Cd2-like, P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP048406.1\|WP_065008530.1\|6187793_6188750_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.93741e-145
NZ_CP048406.1\|WP_163603096.1\|6204355_6205654_+\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|234968	PRK01663, PRK01663, C4-dicarboxylate transporter DctA; Reviewed.	0
NZ_CP048406.1\|WP_065008529.1\|6186051_6187797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NZ_CP048406.1\|WP_065008539.1\|6197506_6198622_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	2.88204e-55
NZ_CP048406.1\|WP_065008528.1\|6185386_6186055_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	5.93317e-117
NZ_CP048406.1\|WP_065008551.1\|6177067_6177718_-\|hypothetical-protein	gnl\|CDD\|238154	cd00250, CAS_like, Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases catalyze a hydroxylation reaction, which leads to the incorporation of an oxygen atom from dioxygen into a hydroxyl group and conversion of 2OG to succinate and CO2.	1.60343e-12
NZ_CP048406.1\|WP_065008538.1\|6196561_6196984_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|133412	cd04785, HTH_CadR-PbrR-like, Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators. Helix-turn-helix (HTH) CadR- and PbrR-like transcription regulators. CadR and PbrR regulate expression of the cadmium and lead resistance operons, respectively. These proteins are comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains have three conserved cysteines which comprise a putative metal binding site. Some members in this group have a histidine-rich C-terminal extension. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	4.89561e-60
NZ_CP048406.1\|WP_065008527.1\|6183039_6185340_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	6.6951e-55

>NZ_CP048406.1|WP_065008530.1|6187793_6188750_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MNALSNRYDFVLLFDVSKGNPNGDPDAGNMPRLDPETNHGLVSDVSLKRKVRNYVEFARGEHQSYNIYVKEGAILNEQHRKAYVALRPDDGKAAKDAKLNPKDDDEGRALTRFMCANFFDVRTFGAVMSTGINAGQVRGPVQMTFASSIEPIVPQEISITRMAATNEAEKKQRVEGSEEGNNRIDNRTMGRKHIVPYGLYRAHGFVSAKLAERTGFSDTDLDLLFEALSTMFEHDRSAARGEMASRKLVVFKHANALGNAPAHALFDRLRIGRNIDGLFRDVHDSGIDNYPPARKYSDYKIEIDRDGMPEGVEIIERL
>NZ_CP048406.1|WP_065008529.1|6186051_6187797_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSILASLAKAYDRLPDAPPFGYSTEKIGFVISLNQDGSVASVTDLRDGTGKKKLPRMMQVPQPTKRTAGIAPNFLWDKTSYVLGVTAGEGKRTADEHAAFVKRHRVALEDSDDTGLLALSLFLEGWAPERFVEPTWPDEMKDQNVVFALDSERRQDGYLHDRPAAKALWMARSGGGDAASICLVTGSNGAVARLHPAIKGVWGAQSSGASIVSFNLDAFMSYEHEQGDNAPVSESAAFKYSTALNTFLAGKTNRIQVGDTSTVFWADASNAEVARTAEGTFGAMFSDVDEVTQAGKVGDILARIRNGLPLKEIAPELENGVRFYVLGLAPNAARLSIRFWFENDFGVLAKNYQRFVAEMEVDPPPRDANPALWKYLAETAVLGKRENVPPNLAGEWMRSILTGSRYPLTLLSTVLMRIRADGEVNALRVSILKALLVRNFNKAIGEAPVSFQPENRNKGYLLGRLFAAYEQIQTAALGRNVNATIKDKFYSSASAQPRKVFPLLDRGSANHLSKVGKQRPGQRVNLEKAIGAILERMSPDSDPFPASLSAEEQALFGLGYYHQRGEFFRKPETVDTQDAAS
>NZ_CP048406.1|WP_065008528.1|6185386_6186055_+|type-I-C-CRISPR-associated-protein-Cas5
MSFGIMLKVSGSHACFTRPEMKVERVSYDVMTPSAARGILEAIHWKPAIRWVVDAIHVLNVIRFQSIRRNEVGSKVSARYAKTAMNRGSLEGLHLLVDEDRQQRAATVLVDVAYLIEAHFELTDKAGPDDNEGKHLDTFNRRAARGQCFHQPCLGTREFAAAFELLPPGAPLPDAIKETRDLGFMLWDIDHGAPDKPSLFFRAGLNNGVMRVPAPNSSEIRR
>NZ_CP048406.1|WP_065008527.1|6183039_6185340_+|CRISPR-associated-helicase/endonuclease-Cas3
MYYAHSTTEPVRSNWQPLDSHLIAVAGLAQQFGARIGIGRAAWLAGLLHDLGKYTPKFQARLSGAQERVDHSTAGAATIVQLAQAAKADDRIVAELIAYCIAGHHAGLPDKQGETFSTLSERLNAFSEAGLDPIWKSEIAPEIANLLPSFPNWEKTDKARAAFQLGFLGRMIFSCLIDADFKDTEQFYARTEGRQVDRNWPELQSILHGLIKSFDAHMDQKRNSDTSVNVLRTNILDHVRSRATEKPGLFTLTVPTGGGKTLASLGFALDQAKAHRLDRIIYAIPFTSIIDQAAAIFREIVGDGVVLEHHSAIEDEERRPREPPDADSTKADKDKLKLAMEDWAAPIVVTTNVQFFESLFAARTSRCRKLHNIANSVIVLDEAQTLPRQLLIPAVWALRELAENYGCSIVLCTATQPALDQRNFPGRHPAGLPLEGRELAPDPADLAEKLERVTLVHGGVMDDTAVLAELGKTNQGLVIVNSRKHALALYLQAKETGLQGLVHLTTRQYAAHRREVLAAVKQRLLNNEACRMIATSLVEAGVDLDFPRLWRAEAGLDQIAQAAGRCNREGRRPVEASIVTVFKAPENQPPPEIAGLSSDMARMMARHEKLLSPAAIEDFFGEVYWRVGPEGLDRGRNDRSAIVDKFRIGGSGTNFSYRSAAENFRMIESGMVPVIVARAEQAKAAIVKLRIETIPSGVIARDLQTYVVQVPPKARARLIACGHVKFAEERLRADQFAVLMTPGLYDPEVGLVWEDAEYLSQEAIGI
>NZ_CP048406.1|WP_082982395.1|6180190_6180880_-|ATP-binding-protein
MAYFRPRTNHDILEMKERGDAEGAALEYKSSRLFEQKNEKVFETLSKELTGFANAIGGVLIIGIEEDSERRISDIRPIQDPSRNETWLEDGLLSRISPSLQISIERIDVESGHLLVLDVPPSRNAPHQAADKRFYARRLFRIDPLLPFEVEDIRRRVSSLSSGASLSSPSKAERSPSRSRTKDSDIFSMFRSRLRASKTRVSHSNGRRAWTDLIPSLSGSFIPVRRETS
>NZ_CP048406.1|WP_065008525.1|6179681_6180149_-|hypothetical-protein
MDVHLQYTDEDGKQHQKTYTYYLKDFHSTYRIKSPNEEVLEQGIKRLENIERTLTNLSRDIKTMQESAFHPTGLNFSRTTLATLSSRAEMKWPGQFLTFQALAEVLEIDVESALRIQNEIFGASHYQGGVNKPLEDIDLPDDIKERIRQRLILPG
>NZ_CP048406.1|WP_065008552.1|6178342_6179308_-|toll/interleukin-1-receptor-domain-containing-protein
MTGVFFSYSHADEALRDQLEKQLSMLKRQGVIDTWHDRRIGAGQEIAQAIDEQINRDDIILLLVSADFLASNYCYDIEMKRAMERHEAQEAIVIPIILWACDWHHAPFGKLNAVPRDGKPITQWADIDEAFLQVAKAVREAADQRNKTAQSQAPATDASATSQPAPRTAEGPRSSNLRLAKSFTQRDKDRFQEEACEFMARFFENSLAELAERNPGIEGVFRRVDANRFFATLYRDGKDIAKATIYMGGDSFGRGINYVRGHTTASNTINESVNVEADDQTIYLTTTGMMHFGGQNEKKLSREGAAERYWENLIRPLQERW
>NZ_CP048406.1|WP_065008524.1|6177868_6178339_-|hypothetical-protein
MLAPEEFTAGTFASAPAGSLILPRNKHEASVIVGLLDGAPTALFLGDRFQFQYFPTAGSENWSGLIIPNVRVEIDESTAFDAAYGNSPLGTVVRAATQLSVYAKAERSFGHRAVPLVSNLPATYDGGVGFTKWHVVLGAGAEKRILLKIDVQTADQ
>NZ_CP048406.1|WP_065008551.1|6177067_6177718_-|hypothetical-protein
MALKAQVESNGYAFLPRHAGVADAALVAAALGVPIAPWDRTTVQQLVPRASSTPNTYSGIFGLGRFPFHTDLAHWLRPPPYLMLRCVRGFDDVPTLLVDGRSIVEAVTIDIVQRAVVRPRRPQSSEMRLLRIWETTDTGHLLRWDEVFLKPASLVGEVAFRKIREHLETVVPVPVALVDAGDTLIVDNWRMLHGRPAISAGREDRRLERVYLGSLN
>NZ_CP048406.1|WP_065008523.1|6176114_6177071_-|hypothetical-protein
MKRTINPGDLVAAWNPQALYDKAERYMQQAHGLDSDEWDHALWSGLALELLARAALANIHPALLAEPDRAGSNLISALGFNPIVKKFTPRSITVSEVFTRLAAMLPEFSAELESFGALHTGRRNAELHSGELGFDGVKGSSWQPKFYQTCAVLLASMGLTLEEFVGADEAKVAEAIIAAAADESAKAVKGDVEAHAQVWKAKSADERSILAAQAELWASRHAGHRVQCPACGSRALVVGGPVSAPVRKLAEDEIVEKQECLPSHFECIACGLKVNGLSRLAVVGLADRYTNTQVYDAAEYYAPAEDEWAGYEEDNNER
>NZ_CP048406.1|WP_065008537.1|6194244_6196491_-|cadmium-translocating-P-type-ATPase
MAATAPQTRYRVEGMDCAGCATKIDSALRRMHGVQDVNVSVTAGTMTVWHTAESDLAAIEKKVTGLGYSVAQLTSEAGQNAKPAGHGTKGGHDHAGHDHAGRHHAGTAKDGHDNGESLHGHDHTPATGPWWNSAKGRLSIASGAALAAAFAIHYVWPATRVWLFIAAMLIALVPIARRAVMAALAGIPFTIEMLMTIAAIGAVIIGAGEEAATVVFLFLVGELLEGVAAGKARSSIQSLTTLVPKTAFLEENGATREVPAEALGVGAVILVRPGDRIPADGKIIEGESAIDESPVSGESVPVRKGVDADVFAGTINGDGVLRITVTAAASDNTIARIVKLVEEAQESKAPTERFIDHFSRWYTPAVVAVGALVAVVPPMAFGDDWNEWIYKGLALLLIGCPCALVISVPAAIAASLSAGAKRGLLMKGGAVLEGLGKITAVALDKTGTLTQGKPVVTDVVAIEISEKEVLSLAAALETGSSHPLALAILRKAKADRVPVPPAAEAKALGGKGVVGRIGGKNVFLGSPIAGGEKVALPPEQAAYIAELNDQGKSVSVLLINDVLAGFIAMRDEPRLDAQAGLKALTDVGIRTVMLTGDNQRTAAAIGKHLDIEVRSELLPEDKQRIVGELKGQGLMVAKVGDGINDAPALAAADIGIAMGGGTDVALETADAAVLHGRVGDVAAMIKLSQATMANIKQNITMALGLKAVFLVTTVVGITGLWPAILADTGATVLVTANAMRLLRWKGGV
>NZ_CP048406.1|WP_065008538.1|6196561_6196984_+|helix-turn-helix-domain-containing-protein
MRSVPIGEAARQSGVKVPTIRYYEQIGLLPAPNRSEGNRRHYETSDLRRLAFIRHSRELGFGIEAIRTLLTLQDNPSQPCATADTIAQARLADVVQRIRSLTALKAELELMVEGCRHGKVGECRVIEVLADHSQCEHARH
>NZ_CP048406.1|WP_065008539.1|6197506_6198622_-|Fic-family-protein
MVWNWEQADWPHFTYDKEELEPLESEFLLRSGEFLGVFRHVGSDDRDQIRIDLISEEALKTSAIEGEYLNRESLQSSLRQQLGLGSENRRIPPAERGIAEMMADVYLHFGHALSHRTLYAWHKMVMSGELRIETIGNYRQHADVMQIVSNRLDKPKVHFEAPPSARVKAEMDAFTAWFNDTAPKGKTPLPALTRAGIAHLYFESIHPFEDGNGRIGRALCGNALAQSLGEPSLIALAYTIERHRKAYYDNLQASNKSNAVTNWLLYFANTVLEAQRVTLVRVEFSVAKAKFYERYRNQFNERQEKVIARMFREGIDGFKGGLSAENYIAITQASRATATRDLQDLVSKGAMTRTGERRHTRYALNILDERR
>NZ_CP048406.1|WP_065008540.1|6198918_6199947_-|LLM-class-flavin-dependent-oxidoreductase
MKNAFPRGLTFGIFDHLDEDGCEIARQYANRLSLAEACDQLGFYAYHLAEHHCTPHGRSPSPNLFLSSVVQRTRHLRVGPMVMLLALYHPLRAFEEICMLDQLSGGRVELGIGRGSLPVELGYFGIAAEAAPGHYTEASEILIKAMNGDTLSYRGRHFELNDVPLTLRSHQRPHPPTWIATNRPESASWAAASGANIACLGPASSVRRITDAFRACRERSADADERGPFLGMLRMVVIARSQTDAYALAAPAYERWLKSFRFLYDLNALQTPPNLPLSLDAAIESELCVVGTASSARQALLDQLEEAGANYLLCQLAFGNLSLDASLYTARTIQSEIMARVT
>NZ_CP048406.1|WP_065008541.1|6200033_6201182_-|histidinol-phosphate-transaminase
MSDAKLQTVLSSLSQVAGQLDVLLSDKPAPDPCCVKLNTNENPFPLPKAIMQSAMAALERQYLYPEDDNVSLRQAASEAYGVSKDQVIAGNGSSELLGLIYRAFLVPGDRMAMMSPGFSFNRKLARLQGAQFLEIGWCADHSLPVEDLLSGPAKDAKFILLANPNNPTGTFVPVADVERLVSQSDRLIVLDEAYVDFAPDNGLHLLDRYPNLLILRTFSKSYATAGIRVGFGLGHPEVIGRLRDLQNVFNMNVIGQAVGISVLGHRAAYAENHKHIKHERQRVTVALSKLGFSVIPSHANFLLARVPAGQEGSWWQAALERQKILVAFFEDAGLENYIRISIGTKNEMDEFLEVATEIAATAKETIPLCRPSAAAASALTSR
>NZ_CP048406.1|WP_065008553.1|6201416_6203198_-|nif-specific-transcriptional-activator-NifA
MSDQDNGRQSEDSAEQTSSSCTSLHDTKRDDSEPAILPSRASALAGIYEISKALTAPSGLEVRLAKVVDLLRSFLQMRHGIISLFDGDGELEIIAGAGRTESCSERCRTYLPRNAIDQVLATDKPLATENIAVHPAFAADMDVLGASDGIPVSFVGVPIRVDANVVGTLTIDHVLHHGSRVWLDYSLCLLPLIANLVGQAVKSHRSFEGDREQPMAKQDSLPKQKRLAPQRNTHVEGMIGDSLALRGLLEKVALVAKAKIAVLLRGESGTGKELVAKAIHELSPRAKRPFIKLNCAALPETVLESELFGHEKGAFTSAFNSRKGRFELADKGTLFLDEIGEISASFQAKLLRVLQEQEFERVGGNQTIKVDVRIIAATNKNLEEAVARNEFRADLYYRISVVPLLVPALRERRSDIPLLAAEFLKNFNDENGLMLTFDPSAIEVLVNCDFPGNIRELENCVYRTAVLAAGPSIGKDDFACCQDKCFAEALHNCRLGKVALQPSPIGPLPLVRAMPPAAGVSSAAVPPPSATEGQPPLDPVGVVHSARMADAERVIQAMERCGWVQAKAARLLGLTPRQIGYVLRKYGIEIKRL
>NZ_CP048406.1|WP_163603096.1|6204355_6205654_+|dicarboxylate/amino-acid:cation-symporter
MVSPIRSAGPAPRKAFCAQPYIQVLTAIALGVAVGYFYPDVGESLKPLGDAFIKLVKMIIAPVIFLTVTTGIAGMNDLKKVGRVAGKAMIYFLTFSSLALIVGLIVANVVQPGAGLNIDPASLDAQAVKGYAAKVHEQSVTGFLMNIIPSTIVSAFAEGDIMQVLFFSVLFGIALAMVGDTGKPVLSLLQALLAPVFKLVGILMRAAPVGAFGAMAFTIGKYGIGSVANLAMLVATFYFTAFLFVFGILGAVCRYNGFSIFSLVRYIKEELLLVLATSSSEAALPSLIAKMENAGAKRSVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATNTHLSIPDQIFLLLVAMLSSKGAAGITGAGFITLAATLSVIPSVPVAGMALILGVDRFMSECRALTNVIGNAVASLVVARWEGELDETRMKAAFYGSLPRD
>NZ_CP048406.1|WP_065011499.1|6205936_6207001_+|LacI-family-transcriptional-regulator
MTERQPIKIGATAKRPTIADLAREAGVSVATVDRVLNARLPVREETARRVHHAAHAIGYHAAGLIKQRMGKDLPRYRLGFILRKPAQHFYQEFAREVEASVSSAHCFHGIPLIEFAPSHLPGDLTALLKDLGSRCHAIAMVAPDHPKITAAVEELKAKGIPVFSLLSDFAAGVREGYIGLNNRSVGRTAAWMFSKVAKRSGKVAVFVGSHRFQGHELRESGFRSYFRENEPAFEVLDTLVNLEKRQITYEALLDLMQREPELVGFYMAGGGMEGAISALREEGKGQDLVAIVNEITPESREALADDIITMAVATPLRRLCQELMLLMDRAIRTGTAETPGQTFLPFDIYLPENI
>NZ_CP048406.1|WP_156768530.1|6207449_6207617_+|hypothetical-protein
MIAWLPERQPGVRPSAFPNLTVDITAMIGLENAPSIEPKSGLAGLQEEANTSEAA
>NZ_CP048406.1|WP_065011504.1|6208659_6209121_+|transposase
MANPLDAEPEITATQPAAKVEGPQKKKAKRSPKAKAEPRPPARKAPNAASQAEEAPAATVRTGRKIYSEKERAQMLALIQKSISGGATLKSAVKQAGISEQTYYQWKKPALPASVGDDLKDLVALEEENKRLKSLLAERLRKENAELKRKLGF

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Crispr_ID: NZ_CP048406_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_6

6189478-6189943

TypeI

Consensus_repeat	Method
GGGCGTGGATCGAAAC	PILER-CR

7 spacers

cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP048406_6

>merge|NZ_CP048406|6|6189478-6189943|PILER-CR
GGGCGAGGATCGAAACGCCTGCATCTTCTTCGTCATGACCTTGGCGGCTGTCGCCCCTCTGACGGGGGCGTGGATCGAAACCGCGTCATCGGAAAGCGCTACGGAAACTTGCTTGTCGCCCCTCTCGCTGGGCGTGGATCGAAACACATGACCATCCAGCAATCGGCCACAGCGCTTATCGTCGCCCATCCCGCGGGCGTGGATCGAAACTGGCCGATCGGCTGCAACCATGAGGGCCAGATCGAGTCGCCCCTCTCGCGGGGGCGTGGACAAACGCATGTGGGCGGCCGGTGTGACGGGAGAAAGCACGTCGCCCCTCTCACGGGGGCGTGGATCGAAACGATTGCGGTGGGCGCCAATGGCGAGGAGCCGGAAGTCGCCCCTCTCGCGGGACGTGGATCGAAACGCCCCTGCGTGGTGGGCCTCATCCGGCACGTAGAGTCGCCCCTTGGGCGTGGATCGAAAC

>NZ_CP048406|6|1|6189478-6189943|PILER-CR
GGGCGAGGATCGAAAC	GCCTGCATCTTCTTCGTCATGACCTTGGCGGCTGTCGCCCCTCTGACGG
GGGCGTGGATCGAAAC	CGCGTCATCGGAAAGCGCTACGGAAACTTGCTTGTCGCCCCTCTCGCT
GGGCGTGGATCGAAAC	ACATGACCATCCAGCAATCGGCCACAGCGCTTATCGTCGCCCATCCCGC
GGGCGTGGATCGAAAC	TGGCCGATCGGCTGCAACCATGAGGGCCAGATCGAGTCGCCCCTCTCGCGG
GGGCGTGGACAAACGC	ATGTGGGCGGCCGGTGTGACGGGAGAAAGCACGTCGCCCCTCTCACGGGGGCGTG
GATCGAAACGATTGCG	GTGGGCGCCAATGGCGAGGAGCCGGAAGTCGCCCCTCTCGCGGGACGTG
GATCGAAACGCCCCTG	CGTGGTGGGCCTCATCCGGCACGTAGAGTCGCCCCTTGGGCGTG
GATCGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_065008552.1\|6178342_6179308_-\|toll/interleukin-1-receptor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379328
NZ_CP048406.1\|WP_156768530.1\|6207449_6207617_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_082982395.1\|6180190_6180880_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|377306
NZ_CP048406.1\|WP_065008541.1\|6200033_6201182_-\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|223157
NZ_CP048406.1\|WP_065008525.1\|6179681_6180149_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008553.1\|6201416_6203198_-\|nif-specific-transcriptional-activator-NifA	unknown	unknown	gnl\|CDD\|273817
NZ_CP048406.1\|WP_065008540.1\|6198918_6199947_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225052
NZ_CP048406.1\|WP_065011499.1\|6205936_6207001_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380530
NZ_CP048406.1\|WP_065008530.1\|6187793_6188750_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NZ_CP048406.1\|WP_065008537.1\|6194244_6196491_-\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319846
NZ_CP048406.1\|WP_065008551.1\|6177067_6177718_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238154
NZ_CP048406.1\|WP_163603096.1\|6204355_6205654_+\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|234968
NZ_CP048406.1\|WP_065008529.1\|6186051_6187797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|378245
NZ_CP048406.1\|WP_065008539.1\|6197506_6198622_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP048406.1\|WP_065011504.1\|6208659_6209121_+\|transposase	unknown	unknown	gnl\|CDD\|366690
NZ_CP048406.1\|WP_065008527.1\|6183039_6185340_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_CP048406.1\|WP_065008528.1\|6185386_6186055_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NZ_CP048406.1\|WP_065008524.1\|6177868_6178339_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008538.1\|6196561_6196984_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|133412
NZ_CP048406.1\|WP_065008523.1\|6176114_6177071_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_065008552.1\|6178342_6179308_-\|toll/interleukin-1-receptor-domain-containing-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	3.25497e-14
NZ_CP048406.1\|WP_082982395.1\|6180190_6180880_-\|ATP-binding-protein	gnl\|CDD\|377306	pfam04326, AlbA_2, Putative DNA-binding domain. This family belongs to the AlbA clan of DNA-binding domains.	4.64389e-17
NZ_CP048406.1\|WP_065008541.1\|6200033_6201182_-\|histidinol-phosphate-transaminase	gnl\|CDD\|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	3.35024e-109
NZ_CP048406.1\|WP_065008553.1\|6201416_6203198_-\|nif-specific-transcriptional-activator-NifA	gnl\|CDD\|273817	TIGR01817, Nif-specific_regulatory_protein, Nif-specific regulatory protein. This model represents NifA, a DNA-binding regulatory protein for nitrogen fixation. The model produces scores between the trusted and noise cutoffs for a well-described NifA homolog in Aquifex aeolicus (which lacks nitrogenase), for transcriptional activators of alternative nitrogenases (VFe or FeFe instead of MoFe), and truncated forms. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, DNA interactions].	0
NZ_CP048406.1\|WP_065011499.1\|6205936_6207001_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|380530	cd06307, PBP1_sugar_binding, periplasmic sugar-binding domain of uncharacterized transport systems. Periplasmic sugar-binding domain of uncharacterized transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes.	6.49906e-90
NZ_CP048406.1\|WP_065011504.1\|6208659_6209121_+\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	7.6748e-07
NZ_CP048406.1\|WP_065008540.1\|6198918_6199947_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	5.04199e-44
NZ_CP048406.1\|WP_065008537.1\|6194244_6196491_-\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319846	cd07546, P-type_ATPase_Pb_Zn_Cd2-like, P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP048406.1\|WP_065008530.1\|6187793_6188750_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.93741e-145
NZ_CP048406.1\|WP_163603096.1\|6204355_6205654_+\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|234968	PRK01663, PRK01663, C4-dicarboxylate transporter DctA; Reviewed.	0
NZ_CP048406.1\|WP_065008529.1\|6186051_6187797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NZ_CP048406.1\|WP_065008539.1\|6197506_6198622_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	2.88204e-55
NZ_CP048406.1\|WP_065008528.1\|6185386_6186055_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	5.93317e-117
NZ_CP048406.1\|WP_065008551.1\|6177067_6177718_-\|hypothetical-protein	gnl\|CDD\|238154	cd00250, CAS_like, Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases catalyze a hydroxylation reaction, which leads to the incorporation of an oxygen atom from dioxygen into a hydroxyl group and conversion of 2OG to succinate and CO2.	1.60343e-12
NZ_CP048406.1\|WP_065008538.1\|6196561_6196984_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|133412	cd04785, HTH_CadR-PbrR-like, Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators. Helix-turn-helix (HTH) CadR- and PbrR-like transcription regulators. CadR and PbrR regulate expression of the cadmium and lead resistance operons, respectively. These proteins are comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains have three conserved cysteines which comprise a putative metal binding site. Some members in this group have a histidine-rich C-terminal extension. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	4.89561e-60
NZ_CP048406.1\|WP_065008527.1\|6183039_6185340_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	6.6951e-55

>NZ_CP048406.1|WP_065008530.1|6187793_6188750_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MNALSNRYDFVLLFDVSKGNPNGDPDAGNMPRLDPETNHGLVSDVSLKRKVRNYVEFARGEHQSYNIYVKEGAILNEQHRKAYVALRPDDGKAAKDAKLNPKDDDEGRALTRFMCANFFDVRTFGAVMSTGINAGQVRGPVQMTFASSIEPIVPQEISITRMAATNEAEKKQRVEGSEEGNNRIDNRTMGRKHIVPYGLYRAHGFVSAKLAERTGFSDTDLDLLFEALSTMFEHDRSAARGEMASRKLVVFKHANALGNAPAHALFDRLRIGRNIDGLFRDVHDSGIDNYPPARKYSDYKIEIDRDGMPEGVEIIERL
>NZ_CP048406.1|WP_065008529.1|6186051_6187797_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSILASLAKAYDRLPDAPPFGYSTEKIGFVISLNQDGSVASVTDLRDGTGKKKLPRMMQVPQPTKRTAGIAPNFLWDKTSYVLGVTAGEGKRTADEHAAFVKRHRVALEDSDDTGLLALSLFLEGWAPERFVEPTWPDEMKDQNVVFALDSERRQDGYLHDRPAAKALWMARSGGGDAASICLVTGSNGAVARLHPAIKGVWGAQSSGASIVSFNLDAFMSYEHEQGDNAPVSESAAFKYSTALNTFLAGKTNRIQVGDTSTVFWADASNAEVARTAEGTFGAMFSDVDEVTQAGKVGDILARIRNGLPLKEIAPELENGVRFYVLGLAPNAARLSIRFWFENDFGVLAKNYQRFVAEMEVDPPPRDANPALWKYLAETAVLGKRENVPPNLAGEWMRSILTGSRYPLTLLSTVLMRIRADGEVNALRVSILKALLVRNFNKAIGEAPVSFQPENRNKGYLLGRLFAAYEQIQTAALGRNVNATIKDKFYSSASAQPRKVFPLLDRGSANHLSKVGKQRPGQRVNLEKAIGAILERMSPDSDPFPASLSAEEQALFGLGYYHQRGEFFRKPETVDTQDAAS
>NZ_CP048406.1|WP_065008528.1|6185386_6186055_+|type-I-C-CRISPR-associated-protein-Cas5
MSFGIMLKVSGSHACFTRPEMKVERVSYDVMTPSAARGILEAIHWKPAIRWVVDAIHVLNVIRFQSIRRNEVGSKVSARYAKTAMNRGSLEGLHLLVDEDRQQRAATVLVDVAYLIEAHFELTDKAGPDDNEGKHLDTFNRRAARGQCFHQPCLGTREFAAAFELLPPGAPLPDAIKETRDLGFMLWDIDHGAPDKPSLFFRAGLNNGVMRVPAPNSSEIRR
>NZ_CP048406.1|WP_065008527.1|6183039_6185340_+|CRISPR-associated-helicase/endonuclease-Cas3
MYYAHSTTEPVRSNWQPLDSHLIAVAGLAQQFGARIGIGRAAWLAGLLHDLGKYTPKFQARLSGAQERVDHSTAGAATIVQLAQAAKADDRIVAELIAYCIAGHHAGLPDKQGETFSTLSERLNAFSEAGLDPIWKSEIAPEIANLLPSFPNWEKTDKARAAFQLGFLGRMIFSCLIDADFKDTEQFYARTEGRQVDRNWPELQSILHGLIKSFDAHMDQKRNSDTSVNVLRTNILDHVRSRATEKPGLFTLTVPTGGGKTLASLGFALDQAKAHRLDRIIYAIPFTSIIDQAAAIFREIVGDGVVLEHHSAIEDEERRPREPPDADSTKADKDKLKLAMEDWAAPIVVTTNVQFFESLFAARTSRCRKLHNIANSVIVLDEAQTLPRQLLIPAVWALRELAENYGCSIVLCTATQPALDQRNFPGRHPAGLPLEGRELAPDPADLAEKLERVTLVHGGVMDDTAVLAELGKTNQGLVIVNSRKHALALYLQAKETGLQGLVHLTTRQYAAHRREVLAAVKQRLLNNEACRMIATSLVEAGVDLDFPRLWRAEAGLDQIAQAAGRCNREGRRPVEASIVTVFKAPENQPPPEIAGLSSDMARMMARHEKLLSPAAIEDFFGEVYWRVGPEGLDRGRNDRSAIVDKFRIGGSGTNFSYRSAAENFRMIESGMVPVIVARAEQAKAAIVKLRIETIPSGVIARDLQTYVVQVPPKARARLIACGHVKFAEERLRADQFAVLMTPGLYDPEVGLVWEDAEYLSQEAIGI
>NZ_CP048406.1|WP_082982395.1|6180190_6180880_-|ATP-binding-protein
MAYFRPRTNHDILEMKERGDAEGAALEYKSSRLFEQKNEKVFETLSKELTGFANAIGGVLIIGIEEDSERRISDIRPIQDPSRNETWLEDGLLSRISPSLQISIERIDVESGHLLVLDVPPSRNAPHQAADKRFYARRLFRIDPLLPFEVEDIRRRVSSLSSGASLSSPSKAERSPSRSRTKDSDIFSMFRSRLRASKTRVSHSNGRRAWTDLIPSLSGSFIPVRRETS
>NZ_CP048406.1|WP_065008525.1|6179681_6180149_-|hypothetical-protein
MDVHLQYTDEDGKQHQKTYTYYLKDFHSTYRIKSPNEEVLEQGIKRLENIERTLTNLSRDIKTMQESAFHPTGLNFSRTTLATLSSRAEMKWPGQFLTFQALAEVLEIDVESALRIQNEIFGASHYQGGVNKPLEDIDLPDDIKERIRQRLILPG
>NZ_CP048406.1|WP_065008552.1|6178342_6179308_-|toll/interleukin-1-receptor-domain-containing-protein
MTGVFFSYSHADEALRDQLEKQLSMLKRQGVIDTWHDRRIGAGQEIAQAIDEQINRDDIILLLVSADFLASNYCYDIEMKRAMERHEAQEAIVIPIILWACDWHHAPFGKLNAVPRDGKPITQWADIDEAFLQVAKAVREAADQRNKTAQSQAPATDASATSQPAPRTAEGPRSSNLRLAKSFTQRDKDRFQEEACEFMARFFENSLAELAERNPGIEGVFRRVDANRFFATLYRDGKDIAKATIYMGGDSFGRGINYVRGHTTASNTINESVNVEADDQTIYLTTTGMMHFGGQNEKKLSREGAAERYWENLIRPLQERW
>NZ_CP048406.1|WP_065008524.1|6177868_6178339_-|hypothetical-protein
MLAPEEFTAGTFASAPAGSLILPRNKHEASVIVGLLDGAPTALFLGDRFQFQYFPTAGSENWSGLIIPNVRVEIDESTAFDAAYGNSPLGTVVRAATQLSVYAKAERSFGHRAVPLVSNLPATYDGGVGFTKWHVVLGAGAEKRILLKIDVQTADQ
>NZ_CP048406.1|WP_065008551.1|6177067_6177718_-|hypothetical-protein
MALKAQVESNGYAFLPRHAGVADAALVAAALGVPIAPWDRTTVQQLVPRASSTPNTYSGIFGLGRFPFHTDLAHWLRPPPYLMLRCVRGFDDVPTLLVDGRSIVEAVTIDIVQRAVVRPRRPQSSEMRLLRIWETTDTGHLLRWDEVFLKPASLVGEVAFRKIREHLETVVPVPVALVDAGDTLIVDNWRMLHGRPAISAGREDRRLERVYLGSLN
>NZ_CP048406.1|WP_065008523.1|6176114_6177071_-|hypothetical-protein
MKRTINPGDLVAAWNPQALYDKAERYMQQAHGLDSDEWDHALWSGLALELLARAALANIHPALLAEPDRAGSNLISALGFNPIVKKFTPRSITVSEVFTRLAAMLPEFSAELESFGALHTGRRNAELHSGELGFDGVKGSSWQPKFYQTCAVLLASMGLTLEEFVGADEAKVAEAIIAAAADESAKAVKGDVEAHAQVWKAKSADERSILAAQAELWASRHAGHRVQCPACGSRALVVGGPVSAPVRKLAEDEIVEKQECLPSHFECIACGLKVNGLSRLAVVGLADRYTNTQVYDAAEYYAPAEDEWAGYEEDNNER
>NZ_CP048406.1|WP_065008537.1|6194244_6196491_-|cadmium-translocating-P-type-ATPase
MAATAPQTRYRVEGMDCAGCATKIDSALRRMHGVQDVNVSVTAGTMTVWHTAESDLAAIEKKVTGLGYSVAQLTSEAGQNAKPAGHGTKGGHDHAGHDHAGRHHAGTAKDGHDNGESLHGHDHTPATGPWWNSAKGRLSIASGAALAAAFAIHYVWPATRVWLFIAAMLIALVPIARRAVMAALAGIPFTIEMLMTIAAIGAVIIGAGEEAATVVFLFLVGELLEGVAAGKARSSIQSLTTLVPKTAFLEENGATREVPAEALGVGAVILVRPGDRIPADGKIIEGESAIDESPVSGESVPVRKGVDADVFAGTINGDGVLRITVTAAASDNTIARIVKLVEEAQESKAPTERFIDHFSRWYTPAVVAVGALVAVVPPMAFGDDWNEWIYKGLALLLIGCPCALVISVPAAIAASLSAGAKRGLLMKGGAVLEGLGKITAVALDKTGTLTQGKPVVTDVVAIEISEKEVLSLAAALETGSSHPLALAILRKAKADRVPVPPAAEAKALGGKGVVGRIGGKNVFLGSPIAGGEKVALPPEQAAYIAELNDQGKSVSVLLINDVLAGFIAMRDEPRLDAQAGLKALTDVGIRTVMLTGDNQRTAAAIGKHLDIEVRSELLPEDKQRIVGELKGQGLMVAKVGDGINDAPALAAADIGIAMGGGTDVALETADAAVLHGRVGDVAAMIKLSQATMANIKQNITMALGLKAVFLVTTVVGITGLWPAILADTGATVLVTANAMRLLRWKGGV
>NZ_CP048406.1|WP_065008538.1|6196561_6196984_+|helix-turn-helix-domain-containing-protein
MRSVPIGEAARQSGVKVPTIRYYEQIGLLPAPNRSEGNRRHYETSDLRRLAFIRHSRELGFGIEAIRTLLTLQDNPSQPCATADTIAQARLADVVQRIRSLTALKAELELMVEGCRHGKVGECRVIEVLADHSQCEHARH
>NZ_CP048406.1|WP_065008539.1|6197506_6198622_-|Fic-family-protein
MVWNWEQADWPHFTYDKEELEPLESEFLLRSGEFLGVFRHVGSDDRDQIRIDLISEEALKTSAIEGEYLNRESLQSSLRQQLGLGSENRRIPPAERGIAEMMADVYLHFGHALSHRTLYAWHKMVMSGELRIETIGNYRQHADVMQIVSNRLDKPKVHFEAPPSARVKAEMDAFTAWFNDTAPKGKTPLPALTRAGIAHLYFESIHPFEDGNGRIGRALCGNALAQSLGEPSLIALAYTIERHRKAYYDNLQASNKSNAVTNWLLYFANTVLEAQRVTLVRVEFSVAKAKFYERYRNQFNERQEKVIARMFREGIDGFKGGLSAENYIAITQASRATATRDLQDLVSKGAMTRTGERRHTRYALNILDERR
>NZ_CP048406.1|WP_065008540.1|6198918_6199947_-|LLM-class-flavin-dependent-oxidoreductase
MKNAFPRGLTFGIFDHLDEDGCEIARQYANRLSLAEACDQLGFYAYHLAEHHCTPHGRSPSPNLFLSSVVQRTRHLRVGPMVMLLALYHPLRAFEEICMLDQLSGGRVELGIGRGSLPVELGYFGIAAEAAPGHYTEASEILIKAMNGDTLSYRGRHFELNDVPLTLRSHQRPHPPTWIATNRPESASWAAASGANIACLGPASSVRRITDAFRACRERSADADERGPFLGMLRMVVIARSQTDAYALAAPAYERWLKSFRFLYDLNALQTPPNLPLSLDAAIESELCVVGTASSARQALLDQLEEAGANYLLCQLAFGNLSLDASLYTARTIQSEIMARVT
>NZ_CP048406.1|WP_065008541.1|6200033_6201182_-|histidinol-phosphate-transaminase
MSDAKLQTVLSSLSQVAGQLDVLLSDKPAPDPCCVKLNTNENPFPLPKAIMQSAMAALERQYLYPEDDNVSLRQAASEAYGVSKDQVIAGNGSSELLGLIYRAFLVPGDRMAMMSPGFSFNRKLARLQGAQFLEIGWCADHSLPVEDLLSGPAKDAKFILLANPNNPTGTFVPVADVERLVSQSDRLIVLDEAYVDFAPDNGLHLLDRYPNLLILRTFSKSYATAGIRVGFGLGHPEVIGRLRDLQNVFNMNVIGQAVGISVLGHRAAYAENHKHIKHERQRVTVALSKLGFSVIPSHANFLLARVPAGQEGSWWQAALERQKILVAFFEDAGLENYIRISIGTKNEMDEFLEVATEIAATAKETIPLCRPSAAAASALTSR
>NZ_CP048406.1|WP_065008553.1|6201416_6203198_-|nif-specific-transcriptional-activator-NifA
MSDQDNGRQSEDSAEQTSSSCTSLHDTKRDDSEPAILPSRASALAGIYEISKALTAPSGLEVRLAKVVDLLRSFLQMRHGIISLFDGDGELEIIAGAGRTESCSERCRTYLPRNAIDQVLATDKPLATENIAVHPAFAADMDVLGASDGIPVSFVGVPIRVDANVVGTLTIDHVLHHGSRVWLDYSLCLLPLIANLVGQAVKSHRSFEGDREQPMAKQDSLPKQKRLAPQRNTHVEGMIGDSLALRGLLEKVALVAKAKIAVLLRGESGTGKELVAKAIHELSPRAKRPFIKLNCAALPETVLESELFGHEKGAFTSAFNSRKGRFELADKGTLFLDEIGEISASFQAKLLRVLQEQEFERVGGNQTIKVDVRIIAATNKNLEEAVARNEFRADLYYRISVVPLLVPALRERRSDIPLLAAEFLKNFNDENGLMLTFDPSAIEVLVNCDFPGNIRELENCVYRTAVLAAGPSIGKDDFACCQDKCFAEALHNCRLGKVALQPSPIGPLPLVRAMPPAAGVSSAAVPPPSATEGQPPLDPVGVVHSARMADAERVIQAMERCGWVQAKAARLLGLTPRQIGYVLRKYGIEIKRL
>NZ_CP048406.1|WP_163603096.1|6204355_6205654_+|dicarboxylate/amino-acid:cation-symporter
MVSPIRSAGPAPRKAFCAQPYIQVLTAIALGVAVGYFYPDVGESLKPLGDAFIKLVKMIIAPVIFLTVTTGIAGMNDLKKVGRVAGKAMIYFLTFSSLALIVGLIVANVVQPGAGLNIDPASLDAQAVKGYAAKVHEQSVTGFLMNIIPSTIVSAFAEGDIMQVLFFSVLFGIALAMVGDTGKPVLSLLQALLAPVFKLVGILMRAAPVGAFGAMAFTIGKYGIGSVANLAMLVATFYFTAFLFVFGILGAVCRYNGFSIFSLVRYIKEELLLVLATSSSEAALPSLIAKMENAGAKRSVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATNTHLSIPDQIFLLLVAMLSSKGAAGITGAGFITLAATLSVIPSVPVAGMALILGVDRFMSECRALTNVIGNAVASLVVARWEGELDETRMKAAFYGSLPRD
>NZ_CP048406.1|WP_065011499.1|6205936_6207001_+|LacI-family-transcriptional-regulator
MTERQPIKIGATAKRPTIADLAREAGVSVATVDRVLNARLPVREETARRVHHAAHAIGYHAAGLIKQRMGKDLPRYRLGFILRKPAQHFYQEFAREVEASVSSAHCFHGIPLIEFAPSHLPGDLTALLKDLGSRCHAIAMVAPDHPKITAAVEELKAKGIPVFSLLSDFAAGVREGYIGLNNRSVGRTAAWMFSKVAKRSGKVAVFVGSHRFQGHELRESGFRSYFRENEPAFEVLDTLVNLEKRQITYEALLDLMQREPELVGFYMAGGGMEGAISALREEGKGQDLVAIVNEITPESREALADDIITMAVATPLRRLCQELMLLMDRAIRTGTAETPGQTFLPFDIYLPENI
>NZ_CP048406.1|WP_156768530.1|6207449_6207617_+|hypothetical-protein
MIAWLPERQPGVRPSAFPNLTVDITAMIGLENAPSIEPKSGLAGLQEEANTSEAA
>NZ_CP048406.1|WP_065011504.1|6208659_6209121_+|transposase
MANPLDAEPEITATQPAAKVEGPQKKKAKRSPKAKAEPRPPARKAPNAASQAEEAPAATVRTGRKIYSEKERAQMLALIQKSISGGATLKSAVKQAGISEQTYYQWKKPALPASVGDDLKDLVALEEENKRLKSLLAERLRKENAELKRKLGF

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Crispr_ID: NZ_CP048406_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_9

6191517-6191989

TypeI

NA:I-C

Consensus_repeat	Method
CGCGGGGGCGTGGATCGAAAC	CRT
GTCGCCCCTCTCGCGGGGGCGTGGATCGAAAC	PILER-CR

7 spacers

cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP048406_9

>merge|NZ_CP048406|9|6191517-6191989|CRT,PILER-CR
TGTCGCCCCGTGGATCGAAACGATAAACGGAACGACGGGCAGCCCCTTCTACGGCAAATCGCCCCTCTCGCGGGGGCGTGGATCGAAACATCAAGCCGCAAGAGCCGATGCTGGTCGAAACAGGTCGCCCCTCTCGCGGGGGCGTGGATCGAAACTCGTGCTGCAGCGGTTACGACTGCCGCGAGGTGTGTCGCCCCTCTCGCGGGGGCGTGGATCGAAACAATCCGTTGACCGCCATCCGCAACGGTGGCTCGGCGTCCCCCCCCTCGCGGGGGCGTGGATCGAAACCGTTAGGCGCTGAGTACCCAGTCGCTACGCGCCTGGTCGCCCCTCTCGCGGGGGCGTGGGTCGAAACTGCCTTGCGCCGTTCCGCTCGTGCGGCATATGCTGTCGCCCGTCTCGCGGGGGGCGTGGATCGAAATCAGAACCACTACACCGAAAAGCGCATGTACCGCGGGGGCGTGGGTGGAAAC

>NZ_CP048406|9|2|6191517-6191989|CRT
TGTCGCCCCGTGGATCGAAAC	GATAAACGGAACGACGGGCAGCCCCTTCTACGGCAAATCGCCCCTCT
CGCGGGGGCGTGGATCGAAAC	ATCAAGCCGCAAGAGCCGATGCTGGTCGAAACAGGTCGCCCCTCT
CGCGGGGGCGTGGATCGAAAC	TCGTGCTGCAGCGGTTACGACTGCCGCGAGGTGTGTCGCCCCTCT
CGCGGGGGCGTGGATCGAAAC	AATCCGTTGACCGCCATCCGCAACGGTGGCTCGGCGTCCCCCCCCT
CGCGGGGGCGTGGATCGAAAC	CGTTAGGCGCTGAGTACCCAGTCGCTACGCGCCTGGTCGCCCCTCT
CGCGGGGGCGTGGGTCGAAAC	TGCCTTGCGCCGTTCCGCTCGTGCGGCATATGCTGTCGCCCGTCTC
GCGGGGGGCGTGGATCGAAAT	CAGAACCACTACACCGAAAAGCGCATGTAC
CGCGGGGGCGTGGGTGGAAAC

>NZ_CP048406|9|4|6191575-6191938|PILER-CR
TCGCCCCTCTCGCGGGGGCGTGGATCGAAACAT	CAAGCCGCAAGAGCCGATGCTGGTCGAAACAGGT
CGCCCCTCTCGCGGGGGCGTGGATCGAAACTCG	TGCTGCAGCGGTTACGACTGCCGCGAGGTGTGTC
GCCCCTCTCGCGGGGGCGTGGATCGAAACAATC	CGTTGACCGCCATCCGCAACGGTGGCTCGGCGTCC
CCCCCCTCGCGGGGGCGTGGATCGAAACCGTTA	GGCGCTGAGTACCCAGTCGCTACGCGCCTGGTCGC
CCCTCTCGCGGGGGCGTGGGTCGAAACTGCCTT	GCGCCGTTCCGCTCGTGCGGCATATGCTGTCGCC
CGTCTCGCGGGGGGCGTGGATCGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_065008552.1\|6178342_6179308_-\|toll/interleukin-1-receptor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379328
NZ_CP048406.1\|WP_156768530.1\|6207449_6207617_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_082982395.1\|6180190_6180880_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|377306
NZ_CP048406.1\|WP_065008541.1\|6200033_6201182_-\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|223157
NZ_CP048406.1\|WP_065008525.1\|6179681_6180149_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008553.1\|6201416_6203198_-\|nif-specific-transcriptional-activator-NifA	unknown	unknown	gnl\|CDD\|273817
NZ_CP048406.1\|WP_065008540.1\|6198918_6199947_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225052
NZ_CP048406.1\|WP_065011499.1\|6205936_6207001_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380530
NZ_CP048406.1\|WP_065008530.1\|6187793_6188750_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NZ_CP048406.1\|WP_065008537.1\|6194244_6196491_-\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319846
NZ_CP048406.1\|WP_065008551.1\|6177067_6177718_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238154
NZ_CP048406.1\|WP_163603096.1\|6204355_6205654_+\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|234968
NZ_CP048406.1\|WP_065008529.1\|6186051_6187797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|378245
NZ_CP048406.1\|WP_065008539.1\|6197506_6198622_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP048406.1\|WP_065011504.1\|6208659_6209121_+\|transposase	unknown	unknown	gnl\|CDD\|366690
NZ_CP048406.1\|WP_065008527.1\|6183039_6185340_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_CP048406.1\|WP_065008528.1\|6185386_6186055_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NZ_CP048406.1\|WP_065008524.1\|6177868_6178339_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008538.1\|6196561_6196984_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|133412
NZ_CP048406.1\|WP_065008523.1\|6176114_6177071_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_065008552.1\|6178342_6179308_-\|toll/interleukin-1-receptor-domain-containing-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	3.25497e-14
NZ_CP048406.1\|WP_082982395.1\|6180190_6180880_-\|ATP-binding-protein	gnl\|CDD\|377306	pfam04326, AlbA_2, Putative DNA-binding domain. This family belongs to the AlbA clan of DNA-binding domains.	4.64389e-17
NZ_CP048406.1\|WP_065008541.1\|6200033_6201182_-\|histidinol-phosphate-transaminase	gnl\|CDD\|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	3.35024e-109
NZ_CP048406.1\|WP_065008553.1\|6201416_6203198_-\|nif-specific-transcriptional-activator-NifA	gnl\|CDD\|273817	TIGR01817, Nif-specific_regulatory_protein, Nif-specific regulatory protein. This model represents NifA, a DNA-binding regulatory protein for nitrogen fixation. The model produces scores between the trusted and noise cutoffs for a well-described NifA homolog in Aquifex aeolicus (which lacks nitrogenase), for transcriptional activators of alternative nitrogenases (VFe or FeFe instead of MoFe), and truncated forms. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, DNA interactions].	0
NZ_CP048406.1\|WP_065011499.1\|6205936_6207001_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|380530	cd06307, PBP1_sugar_binding, periplasmic sugar-binding domain of uncharacterized transport systems. Periplasmic sugar-binding domain of uncharacterized transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes.	6.49906e-90
NZ_CP048406.1\|WP_065011504.1\|6208659_6209121_+\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	7.6748e-07
NZ_CP048406.1\|WP_065008540.1\|6198918_6199947_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	5.04199e-44
NZ_CP048406.1\|WP_065008537.1\|6194244_6196491_-\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319846	cd07546, P-type_ATPase_Pb_Zn_Cd2-like, P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP048406.1\|WP_065008530.1\|6187793_6188750_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.93741e-145
NZ_CP048406.1\|WP_163603096.1\|6204355_6205654_+\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|234968	PRK01663, PRK01663, C4-dicarboxylate transporter DctA; Reviewed.	0
NZ_CP048406.1\|WP_065008529.1\|6186051_6187797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NZ_CP048406.1\|WP_065008539.1\|6197506_6198622_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	2.88204e-55
NZ_CP048406.1\|WP_065008528.1\|6185386_6186055_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	5.93317e-117
NZ_CP048406.1\|WP_065008551.1\|6177067_6177718_-\|hypothetical-protein	gnl\|CDD\|238154	cd00250, CAS_like, Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases catalyze a hydroxylation reaction, which leads to the incorporation of an oxygen atom from dioxygen into a hydroxyl group and conversion of 2OG to succinate and CO2.	1.60343e-12
NZ_CP048406.1\|WP_065008538.1\|6196561_6196984_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|133412	cd04785, HTH_CadR-PbrR-like, Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators. Helix-turn-helix (HTH) CadR- and PbrR-like transcription regulators. CadR and PbrR regulate expression of the cadmium and lead resistance operons, respectively. These proteins are comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains have three conserved cysteines which comprise a putative metal binding site. Some members in this group have a histidine-rich C-terminal extension. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	4.89561e-60
NZ_CP048406.1\|WP_065008527.1\|6183039_6185340_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	6.6951e-55

>NZ_CP048406.1|WP_065008530.1|6187793_6188750_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MNALSNRYDFVLLFDVSKGNPNGDPDAGNMPRLDPETNHGLVSDVSLKRKVRNYVEFARGEHQSYNIYVKEGAILNEQHRKAYVALRPDDGKAAKDAKLNPKDDDEGRALTRFMCANFFDVRTFGAVMSTGINAGQVRGPVQMTFASSIEPIVPQEISITRMAATNEAEKKQRVEGSEEGNNRIDNRTMGRKHIVPYGLYRAHGFVSAKLAERTGFSDTDLDLLFEALSTMFEHDRSAARGEMASRKLVVFKHANALGNAPAHALFDRLRIGRNIDGLFRDVHDSGIDNYPPARKYSDYKIEIDRDGMPEGVEIIERL
>NZ_CP048406.1|WP_065008529.1|6186051_6187797_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSILASLAKAYDRLPDAPPFGYSTEKIGFVISLNQDGSVASVTDLRDGTGKKKLPRMMQVPQPTKRTAGIAPNFLWDKTSYVLGVTAGEGKRTADEHAAFVKRHRVALEDSDDTGLLALSLFLEGWAPERFVEPTWPDEMKDQNVVFALDSERRQDGYLHDRPAAKALWMARSGGGDAASICLVTGSNGAVARLHPAIKGVWGAQSSGASIVSFNLDAFMSYEHEQGDNAPVSESAAFKYSTALNTFLAGKTNRIQVGDTSTVFWADASNAEVARTAEGTFGAMFSDVDEVTQAGKVGDILARIRNGLPLKEIAPELENGVRFYVLGLAPNAARLSIRFWFENDFGVLAKNYQRFVAEMEVDPPPRDANPALWKYLAETAVLGKRENVPPNLAGEWMRSILTGSRYPLTLLSTVLMRIRADGEVNALRVSILKALLVRNFNKAIGEAPVSFQPENRNKGYLLGRLFAAYEQIQTAALGRNVNATIKDKFYSSASAQPRKVFPLLDRGSANHLSKVGKQRPGQRVNLEKAIGAILERMSPDSDPFPASLSAEEQALFGLGYYHQRGEFFRKPETVDTQDAAS
>NZ_CP048406.1|WP_065008528.1|6185386_6186055_+|type-I-C-CRISPR-associated-protein-Cas5
MSFGIMLKVSGSHACFTRPEMKVERVSYDVMTPSAARGILEAIHWKPAIRWVVDAIHVLNVIRFQSIRRNEVGSKVSARYAKTAMNRGSLEGLHLLVDEDRQQRAATVLVDVAYLIEAHFELTDKAGPDDNEGKHLDTFNRRAARGQCFHQPCLGTREFAAAFELLPPGAPLPDAIKETRDLGFMLWDIDHGAPDKPSLFFRAGLNNGVMRVPAPNSSEIRR
>NZ_CP048406.1|WP_065008527.1|6183039_6185340_+|CRISPR-associated-helicase/endonuclease-Cas3
MYYAHSTTEPVRSNWQPLDSHLIAVAGLAQQFGARIGIGRAAWLAGLLHDLGKYTPKFQARLSGAQERVDHSTAGAATIVQLAQAAKADDRIVAELIAYCIAGHHAGLPDKQGETFSTLSERLNAFSEAGLDPIWKSEIAPEIANLLPSFPNWEKTDKARAAFQLGFLGRMIFSCLIDADFKDTEQFYARTEGRQVDRNWPELQSILHGLIKSFDAHMDQKRNSDTSVNVLRTNILDHVRSRATEKPGLFTLTVPTGGGKTLASLGFALDQAKAHRLDRIIYAIPFTSIIDQAAAIFREIVGDGVVLEHHSAIEDEERRPREPPDADSTKADKDKLKLAMEDWAAPIVVTTNVQFFESLFAARTSRCRKLHNIANSVIVLDEAQTLPRQLLIPAVWALRELAENYGCSIVLCTATQPALDQRNFPGRHPAGLPLEGRELAPDPADLAEKLERVTLVHGGVMDDTAVLAELGKTNQGLVIVNSRKHALALYLQAKETGLQGLVHLTTRQYAAHRREVLAAVKQRLLNNEACRMIATSLVEAGVDLDFPRLWRAEAGLDQIAQAAGRCNREGRRPVEASIVTVFKAPENQPPPEIAGLSSDMARMMARHEKLLSPAAIEDFFGEVYWRVGPEGLDRGRNDRSAIVDKFRIGGSGTNFSYRSAAENFRMIESGMVPVIVARAEQAKAAIVKLRIETIPSGVIARDLQTYVVQVPPKARARLIACGHVKFAEERLRADQFAVLMTPGLYDPEVGLVWEDAEYLSQEAIGI
>NZ_CP048406.1|WP_082982395.1|6180190_6180880_-|ATP-binding-protein
MAYFRPRTNHDILEMKERGDAEGAALEYKSSRLFEQKNEKVFETLSKELTGFANAIGGVLIIGIEEDSERRISDIRPIQDPSRNETWLEDGLLSRISPSLQISIERIDVESGHLLVLDVPPSRNAPHQAADKRFYARRLFRIDPLLPFEVEDIRRRVSSLSSGASLSSPSKAERSPSRSRTKDSDIFSMFRSRLRASKTRVSHSNGRRAWTDLIPSLSGSFIPVRRETS
>NZ_CP048406.1|WP_065008525.1|6179681_6180149_-|hypothetical-protein
MDVHLQYTDEDGKQHQKTYTYYLKDFHSTYRIKSPNEEVLEQGIKRLENIERTLTNLSRDIKTMQESAFHPTGLNFSRTTLATLSSRAEMKWPGQFLTFQALAEVLEIDVESALRIQNEIFGASHYQGGVNKPLEDIDLPDDIKERIRQRLILPG
>NZ_CP048406.1|WP_065008552.1|6178342_6179308_-|toll/interleukin-1-receptor-domain-containing-protein
MTGVFFSYSHADEALRDQLEKQLSMLKRQGVIDTWHDRRIGAGQEIAQAIDEQINRDDIILLLVSADFLASNYCYDIEMKRAMERHEAQEAIVIPIILWACDWHHAPFGKLNAVPRDGKPITQWADIDEAFLQVAKAVREAADQRNKTAQSQAPATDASATSQPAPRTAEGPRSSNLRLAKSFTQRDKDRFQEEACEFMARFFENSLAELAERNPGIEGVFRRVDANRFFATLYRDGKDIAKATIYMGGDSFGRGINYVRGHTTASNTINESVNVEADDQTIYLTTTGMMHFGGQNEKKLSREGAAERYWENLIRPLQERW
>NZ_CP048406.1|WP_065008524.1|6177868_6178339_-|hypothetical-protein
MLAPEEFTAGTFASAPAGSLILPRNKHEASVIVGLLDGAPTALFLGDRFQFQYFPTAGSENWSGLIIPNVRVEIDESTAFDAAYGNSPLGTVVRAATQLSVYAKAERSFGHRAVPLVSNLPATYDGGVGFTKWHVVLGAGAEKRILLKIDVQTADQ
>NZ_CP048406.1|WP_065008551.1|6177067_6177718_-|hypothetical-protein
MALKAQVESNGYAFLPRHAGVADAALVAAALGVPIAPWDRTTVQQLVPRASSTPNTYSGIFGLGRFPFHTDLAHWLRPPPYLMLRCVRGFDDVPTLLVDGRSIVEAVTIDIVQRAVVRPRRPQSSEMRLLRIWETTDTGHLLRWDEVFLKPASLVGEVAFRKIREHLETVVPVPVALVDAGDTLIVDNWRMLHGRPAISAGREDRRLERVYLGSLN
>NZ_CP048406.1|WP_065008523.1|6176114_6177071_-|hypothetical-protein
MKRTINPGDLVAAWNPQALYDKAERYMQQAHGLDSDEWDHALWSGLALELLARAALANIHPALLAEPDRAGSNLISALGFNPIVKKFTPRSITVSEVFTRLAAMLPEFSAELESFGALHTGRRNAELHSGELGFDGVKGSSWQPKFYQTCAVLLASMGLTLEEFVGADEAKVAEAIIAAAADESAKAVKGDVEAHAQVWKAKSADERSILAAQAELWASRHAGHRVQCPACGSRALVVGGPVSAPVRKLAEDEIVEKQECLPSHFECIACGLKVNGLSRLAVVGLADRYTNTQVYDAAEYYAPAEDEWAGYEEDNNER
>NZ_CP048406.1|WP_065008537.1|6194244_6196491_-|cadmium-translocating-P-type-ATPase
MAATAPQTRYRVEGMDCAGCATKIDSALRRMHGVQDVNVSVTAGTMTVWHTAESDLAAIEKKVTGLGYSVAQLTSEAGQNAKPAGHGTKGGHDHAGHDHAGRHHAGTAKDGHDNGESLHGHDHTPATGPWWNSAKGRLSIASGAALAAAFAIHYVWPATRVWLFIAAMLIALVPIARRAVMAALAGIPFTIEMLMTIAAIGAVIIGAGEEAATVVFLFLVGELLEGVAAGKARSSIQSLTTLVPKTAFLEENGATREVPAEALGVGAVILVRPGDRIPADGKIIEGESAIDESPVSGESVPVRKGVDADVFAGTINGDGVLRITVTAAASDNTIARIVKLVEEAQESKAPTERFIDHFSRWYTPAVVAVGALVAVVPPMAFGDDWNEWIYKGLALLLIGCPCALVISVPAAIAASLSAGAKRGLLMKGGAVLEGLGKITAVALDKTGTLTQGKPVVTDVVAIEISEKEVLSLAAALETGSSHPLALAILRKAKADRVPVPPAAEAKALGGKGVVGRIGGKNVFLGSPIAGGEKVALPPEQAAYIAELNDQGKSVSVLLINDVLAGFIAMRDEPRLDAQAGLKALTDVGIRTVMLTGDNQRTAAAIGKHLDIEVRSELLPEDKQRIVGELKGQGLMVAKVGDGINDAPALAAADIGIAMGGGTDVALETADAAVLHGRVGDVAAMIKLSQATMANIKQNITMALGLKAVFLVTTVVGITGLWPAILADTGATVLVTANAMRLLRWKGGV
>NZ_CP048406.1|WP_065008538.1|6196561_6196984_+|helix-turn-helix-domain-containing-protein
MRSVPIGEAARQSGVKVPTIRYYEQIGLLPAPNRSEGNRRHYETSDLRRLAFIRHSRELGFGIEAIRTLLTLQDNPSQPCATADTIAQARLADVVQRIRSLTALKAELELMVEGCRHGKVGECRVIEVLADHSQCEHARH
>NZ_CP048406.1|WP_065008539.1|6197506_6198622_-|Fic-family-protein
MVWNWEQADWPHFTYDKEELEPLESEFLLRSGEFLGVFRHVGSDDRDQIRIDLISEEALKTSAIEGEYLNRESLQSSLRQQLGLGSENRRIPPAERGIAEMMADVYLHFGHALSHRTLYAWHKMVMSGELRIETIGNYRQHADVMQIVSNRLDKPKVHFEAPPSARVKAEMDAFTAWFNDTAPKGKTPLPALTRAGIAHLYFESIHPFEDGNGRIGRALCGNALAQSLGEPSLIALAYTIERHRKAYYDNLQASNKSNAVTNWLLYFANTVLEAQRVTLVRVEFSVAKAKFYERYRNQFNERQEKVIARMFREGIDGFKGGLSAENYIAITQASRATATRDLQDLVSKGAMTRTGERRHTRYALNILDERR
>NZ_CP048406.1|WP_065008540.1|6198918_6199947_-|LLM-class-flavin-dependent-oxidoreductase
MKNAFPRGLTFGIFDHLDEDGCEIARQYANRLSLAEACDQLGFYAYHLAEHHCTPHGRSPSPNLFLSSVVQRTRHLRVGPMVMLLALYHPLRAFEEICMLDQLSGGRVELGIGRGSLPVELGYFGIAAEAAPGHYTEASEILIKAMNGDTLSYRGRHFELNDVPLTLRSHQRPHPPTWIATNRPESASWAAASGANIACLGPASSVRRITDAFRACRERSADADERGPFLGMLRMVVIARSQTDAYALAAPAYERWLKSFRFLYDLNALQTPPNLPLSLDAAIESELCVVGTASSARQALLDQLEEAGANYLLCQLAFGNLSLDASLYTARTIQSEIMARVT
>NZ_CP048406.1|WP_065008541.1|6200033_6201182_-|histidinol-phosphate-transaminase
MSDAKLQTVLSSLSQVAGQLDVLLSDKPAPDPCCVKLNTNENPFPLPKAIMQSAMAALERQYLYPEDDNVSLRQAASEAYGVSKDQVIAGNGSSELLGLIYRAFLVPGDRMAMMSPGFSFNRKLARLQGAQFLEIGWCADHSLPVEDLLSGPAKDAKFILLANPNNPTGTFVPVADVERLVSQSDRLIVLDEAYVDFAPDNGLHLLDRYPNLLILRTFSKSYATAGIRVGFGLGHPEVIGRLRDLQNVFNMNVIGQAVGISVLGHRAAYAENHKHIKHERQRVTVALSKLGFSVIPSHANFLLARVPAGQEGSWWQAALERQKILVAFFEDAGLENYIRISIGTKNEMDEFLEVATEIAATAKETIPLCRPSAAAASALTSR
>NZ_CP048406.1|WP_065008553.1|6201416_6203198_-|nif-specific-transcriptional-activator-NifA
MSDQDNGRQSEDSAEQTSSSCTSLHDTKRDDSEPAILPSRASALAGIYEISKALTAPSGLEVRLAKVVDLLRSFLQMRHGIISLFDGDGELEIIAGAGRTESCSERCRTYLPRNAIDQVLATDKPLATENIAVHPAFAADMDVLGASDGIPVSFVGVPIRVDANVVGTLTIDHVLHHGSRVWLDYSLCLLPLIANLVGQAVKSHRSFEGDREQPMAKQDSLPKQKRLAPQRNTHVEGMIGDSLALRGLLEKVALVAKAKIAVLLRGESGTGKELVAKAIHELSPRAKRPFIKLNCAALPETVLESELFGHEKGAFTSAFNSRKGRFELADKGTLFLDEIGEISASFQAKLLRVLQEQEFERVGGNQTIKVDVRIIAATNKNLEEAVARNEFRADLYYRISVVPLLVPALRERRSDIPLLAAEFLKNFNDENGLMLTFDPSAIEVLVNCDFPGNIRELENCVYRTAVLAAGPSIGKDDFACCQDKCFAEALHNCRLGKVALQPSPIGPLPLVRAMPPAAGVSSAAVPPPSATEGQPPLDPVGVVHSARMADAERVIQAMERCGWVQAKAARLLGLTPRQIGYVLRKYGIEIKRL
>NZ_CP048406.1|WP_163603096.1|6204355_6205654_+|dicarboxylate/amino-acid:cation-symporter
MVSPIRSAGPAPRKAFCAQPYIQVLTAIALGVAVGYFYPDVGESLKPLGDAFIKLVKMIIAPVIFLTVTTGIAGMNDLKKVGRVAGKAMIYFLTFSSLALIVGLIVANVVQPGAGLNIDPASLDAQAVKGYAAKVHEQSVTGFLMNIIPSTIVSAFAEGDIMQVLFFSVLFGIALAMVGDTGKPVLSLLQALLAPVFKLVGILMRAAPVGAFGAMAFTIGKYGIGSVANLAMLVATFYFTAFLFVFGILGAVCRYNGFSIFSLVRYIKEELLLVLATSSSEAALPSLIAKMENAGAKRSVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATNTHLSIPDQIFLLLVAMLSSKGAAGITGAGFITLAATLSVIPSVPVAGMALILGVDRFMSECRALTNVIGNAVASLVVARWEGELDETRMKAAFYGSLPRD
>NZ_CP048406.1|WP_065011499.1|6205936_6207001_+|LacI-family-transcriptional-regulator
MTERQPIKIGATAKRPTIADLAREAGVSVATVDRVLNARLPVREETARRVHHAAHAIGYHAAGLIKQRMGKDLPRYRLGFILRKPAQHFYQEFAREVEASVSSAHCFHGIPLIEFAPSHLPGDLTALLKDLGSRCHAIAMVAPDHPKITAAVEELKAKGIPVFSLLSDFAAGVREGYIGLNNRSVGRTAAWMFSKVAKRSGKVAVFVGSHRFQGHELRESGFRSYFRENEPAFEVLDTLVNLEKRQITYEALLDLMQREPELVGFYMAGGGMEGAISALREEGKGQDLVAIVNEITPESREALADDIITMAVATPLRRLCQELMLLMDRAIRTGTAETPGQTFLPFDIYLPENI
>NZ_CP048406.1|WP_156768530.1|6207449_6207617_+|hypothetical-protein
MIAWLPERQPGVRPSAFPNLTVDITAMIGLENAPSIEPKSGLAGLQEEANTSEAA
>NZ_CP048406.1|WP_065011504.1|6208659_6209121_+|transposase
MANPLDAEPEITATQPAAKVEGPQKKKAKRSPKAKAEPRPPARKAPNAASQAEEAPAATVRTGRKIYSEKERAQMLALIQKSISGGATLKSAVKQAGISEQTYYQWKKPALPASVGDDLKDLVALEEENKRLKSLLAERLRKENAELKRKLGF

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Crispr_ID: NZ_CP048406_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_7

6190314-6191027

TypeI

Consensus_repeat	Method
GNGGGCGTGGATCGAAAC	CRT
GGGGGCGTGGATCGAAAC	PILER-CR

11 spacers

cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP048406_7

>merge|NZ_CP048406|7|6190314-6191027|CRT,PILER-CR
GGAGGCGTGGATCGAAACATGTTCGCTTCCAAGAAGGCTGTCGCCCCGCTGGCGTGGATCGAAACCGAAACCGAGCCGGAGATGAAGGCCGAGCAACGCCGCTCGCCTCTCACGGGGGCGTGGATCGAAACGTCGTCACGACGCAGGGACCCCTTCGAATGTGTCAGTCGCCCCTCTCGGGGGGGCGTGGATCGAAACCACGAGCGATGGCGCTTTGTGACACAGGCAAGGTGTCGCCCCTCTCGCGGGGGCGTGGATCGAAACATGCTCAACGTCGCGCCGTTCTTCATTGGGCGACAGTCGCCCTCTCACGGGGGCGTGGATCGAAACTTCATGGATGAGACCGAAGCCGCGACGATCAAGAGTCGCCCTCTCACGGGGCGTGGATCGAAACTGCTGCTCGGCCGGCATGGCGAGATCCATTTCGAGTCGCCCTCTCACGAGGGCGTGGATAGAAACGGGTCTTTGTCGTAGGTATCGAGCGCAATGCGTCGCCCCCTCTCACGGGGGCGTGGATCGAAACAGATGGAGGCTGTAGGAATGCCGCGCCACCTTGGTCGCCCCTCTCAGGGGGCGTGGATCGAAACATCGCCGAGGCGCAAGTGTTCCTCCCGACCGGTGGTCGCCCCTCAGGGCGTGGACCGAAACTTGCCGTCTACGCCGATCTCGCGCACCAGGCCGCGTCGCCCCCACCACGTGGGCGTGGATCGAAAC

>NZ_CP048406|7|1|6190314-6191027|CRT
GGAGGCGTGGATCGAAAC	ATGTTCGCTTCCAAGAAGGCTGTCGCCCC
GCTGGCGTGGATCGAAAC	CGAAACCGAGCCGGAGATGAAGGCCGAGCAACGCCGCTCGCCTCTCAC
GGGGGCGTGGATCGAAAC	GTCGTCACGACGCAGGGACCCCTTCGAATGTGTCAGTCGCCCCTCTCGG
GGGGGCGTGGATCGAAAC	CACGAGCGATGGCGCTTTGTGACACAGGCAAGGTGTCGCCCCTCTCGC
GGGGGCGTGGATCGAAAC	ATGCTCAACGTCGCGCCGTTCTTCATTGGGCGACAGTCGCCCTCTCAC
GGGGGCGTGGATCGAAAC	TTCATGGATGAGACCGAAGCCGCGACGATCAAGAGTCGCCCTCTCA
CGGGGCGTGGATCGAAAC	TGCTGCTCGGCCGGCATGGCGAGATCCATTTCGAGTCGCCCTCTCAC
GAGGGCGTGGATAGAAAC	GGGTCTTTGTCGTAGGTATCGAGCGCAATGCGTCGCCCCCTCTCAC
GGGGGCGTGGATCGAAAC	AGATGGAGGCTGTAGGAATGCCGCGCCACCTTGGTCGCCCCTCTCA
GGGGGCGTGGATCGAAAC	ATCGCCGAGGCGCAAGTGTTCCTCCCGACCGGTGGTCGCCCCT
CAGGGCGTGGACCGAAAC	TTGCCGTCTACGCCGATCTCGCGCACCAGGCCGCGTCGCCCCCACCAC
GTGGGCGTGGATCGAAAC

>NZ_CP048406|7|2|6190427-6190643|PILER-CR
GGGGGCGTGGATCGAAAC	GTCGTCACGACGCAGGGACCCCTTCGAATGTGTCAGTCGCCCCTCTCGG
GGGGGCGTGGATCGAAAC	CACGAGCGATGGCGCTTTGTGACACAGGCAAGGTGTCGCCCCTCTCGC
GGGGGCGTGGATCGAAAC	ATGCTCAACGTCGCGCCGTTCTTCATTGGGCGACAGTCGCCCTCTCAC
GGGGGCGTGGATCGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_065008552.1\|6178342_6179308_-\|toll/interleukin-1-receptor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379328
NZ_CP048406.1\|WP_156768530.1\|6207449_6207617_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_082982395.1\|6180190_6180880_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|377306
NZ_CP048406.1\|WP_065008541.1\|6200033_6201182_-\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|223157
NZ_CP048406.1\|WP_065008525.1\|6179681_6180149_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008553.1\|6201416_6203198_-\|nif-specific-transcriptional-activator-NifA	unknown	unknown	gnl\|CDD\|273817
NZ_CP048406.1\|WP_065008540.1\|6198918_6199947_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225052
NZ_CP048406.1\|WP_065011499.1\|6205936_6207001_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380530
NZ_CP048406.1\|WP_065008530.1\|6187793_6188750_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NZ_CP048406.1\|WP_065008537.1\|6194244_6196491_-\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319846
NZ_CP048406.1\|WP_065008551.1\|6177067_6177718_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238154
NZ_CP048406.1\|WP_163603096.1\|6204355_6205654_+\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|234968
NZ_CP048406.1\|WP_065008529.1\|6186051_6187797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|378245
NZ_CP048406.1\|WP_065008539.1\|6197506_6198622_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP048406.1\|WP_065011504.1\|6208659_6209121_+\|transposase	unknown	unknown	gnl\|CDD\|366690
NZ_CP048406.1\|WP_065008527.1\|6183039_6185340_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_CP048406.1\|WP_065008528.1\|6185386_6186055_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NZ_CP048406.1\|WP_065008524.1\|6177868_6178339_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008538.1\|6196561_6196984_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|133412
NZ_CP048406.1\|WP_065008523.1\|6176114_6177071_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_065008552.1\|6178342_6179308_-\|toll/interleukin-1-receptor-domain-containing-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	3.25497e-14
NZ_CP048406.1\|WP_082982395.1\|6180190_6180880_-\|ATP-binding-protein	gnl\|CDD\|377306	pfam04326, AlbA_2, Putative DNA-binding domain. This family belongs to the AlbA clan of DNA-binding domains.	4.64389e-17
NZ_CP048406.1\|WP_065008541.1\|6200033_6201182_-\|histidinol-phosphate-transaminase	gnl\|CDD\|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	3.35024e-109
NZ_CP048406.1\|WP_065008553.1\|6201416_6203198_-\|nif-specific-transcriptional-activator-NifA	gnl\|CDD\|273817	TIGR01817, Nif-specific_regulatory_protein, Nif-specific regulatory protein. This model represents NifA, a DNA-binding regulatory protein for nitrogen fixation. The model produces scores between the trusted and noise cutoffs for a well-described NifA homolog in Aquifex aeolicus (which lacks nitrogenase), for transcriptional activators of alternative nitrogenases (VFe or FeFe instead of MoFe), and truncated forms. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, DNA interactions].	0
NZ_CP048406.1\|WP_065011499.1\|6205936_6207001_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|380530	cd06307, PBP1_sugar_binding, periplasmic sugar-binding domain of uncharacterized transport systems. Periplasmic sugar-binding domain of uncharacterized transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes.	6.49906e-90
NZ_CP048406.1\|WP_065011504.1\|6208659_6209121_+\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	7.6748e-07
NZ_CP048406.1\|WP_065008540.1\|6198918_6199947_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	5.04199e-44
NZ_CP048406.1\|WP_065008537.1\|6194244_6196491_-\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319846	cd07546, P-type_ATPase_Pb_Zn_Cd2-like, P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP048406.1\|WP_065008530.1\|6187793_6188750_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.93741e-145
NZ_CP048406.1\|WP_163603096.1\|6204355_6205654_+\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|234968	PRK01663, PRK01663, C4-dicarboxylate transporter DctA; Reviewed.	0
NZ_CP048406.1\|WP_065008529.1\|6186051_6187797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NZ_CP048406.1\|WP_065008539.1\|6197506_6198622_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	2.88204e-55
NZ_CP048406.1\|WP_065008528.1\|6185386_6186055_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	5.93317e-117
NZ_CP048406.1\|WP_065008551.1\|6177067_6177718_-\|hypothetical-protein	gnl\|CDD\|238154	cd00250, CAS_like, Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases catalyze a hydroxylation reaction, which leads to the incorporation of an oxygen atom from dioxygen into a hydroxyl group and conversion of 2OG to succinate and CO2.	1.60343e-12
NZ_CP048406.1\|WP_065008538.1\|6196561_6196984_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|133412	cd04785, HTH_CadR-PbrR-like, Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators. Helix-turn-helix (HTH) CadR- and PbrR-like transcription regulators. CadR and PbrR regulate expression of the cadmium and lead resistance operons, respectively. These proteins are comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains have three conserved cysteines which comprise a putative metal binding site. Some members in this group have a histidine-rich C-terminal extension. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	4.89561e-60
NZ_CP048406.1\|WP_065008527.1\|6183039_6185340_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	6.6951e-55

>NZ_CP048406.1|WP_065008530.1|6187793_6188750_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MNALSNRYDFVLLFDVSKGNPNGDPDAGNMPRLDPETNHGLVSDVSLKRKVRNYVEFARGEHQSYNIYVKEGAILNEQHRKAYVALRPDDGKAAKDAKLNPKDDDEGRALTRFMCANFFDVRTFGAVMSTGINAGQVRGPVQMTFASSIEPIVPQEISITRMAATNEAEKKQRVEGSEEGNNRIDNRTMGRKHIVPYGLYRAHGFVSAKLAERTGFSDTDLDLLFEALSTMFEHDRSAARGEMASRKLVVFKHANALGNAPAHALFDRLRIGRNIDGLFRDVHDSGIDNYPPARKYSDYKIEIDRDGMPEGVEIIERL
>NZ_CP048406.1|WP_065008529.1|6186051_6187797_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSILASLAKAYDRLPDAPPFGYSTEKIGFVISLNQDGSVASVTDLRDGTGKKKLPRMMQVPQPTKRTAGIAPNFLWDKTSYVLGVTAGEGKRTADEHAAFVKRHRVALEDSDDTGLLALSLFLEGWAPERFVEPTWPDEMKDQNVVFALDSERRQDGYLHDRPAAKALWMARSGGGDAASICLVTGSNGAVARLHPAIKGVWGAQSSGASIVSFNLDAFMSYEHEQGDNAPVSESAAFKYSTALNTFLAGKTNRIQVGDTSTVFWADASNAEVARTAEGTFGAMFSDVDEVTQAGKVGDILARIRNGLPLKEIAPELENGVRFYVLGLAPNAARLSIRFWFENDFGVLAKNYQRFVAEMEVDPPPRDANPALWKYLAETAVLGKRENVPPNLAGEWMRSILTGSRYPLTLLSTVLMRIRADGEVNALRVSILKALLVRNFNKAIGEAPVSFQPENRNKGYLLGRLFAAYEQIQTAALGRNVNATIKDKFYSSASAQPRKVFPLLDRGSANHLSKVGKQRPGQRVNLEKAIGAILERMSPDSDPFPASLSAEEQALFGLGYYHQRGEFFRKPETVDTQDAAS
>NZ_CP048406.1|WP_065008528.1|6185386_6186055_+|type-I-C-CRISPR-associated-protein-Cas5
MSFGIMLKVSGSHACFTRPEMKVERVSYDVMTPSAARGILEAIHWKPAIRWVVDAIHVLNVIRFQSIRRNEVGSKVSARYAKTAMNRGSLEGLHLLVDEDRQQRAATVLVDVAYLIEAHFELTDKAGPDDNEGKHLDTFNRRAARGQCFHQPCLGTREFAAAFELLPPGAPLPDAIKETRDLGFMLWDIDHGAPDKPSLFFRAGLNNGVMRVPAPNSSEIRR
>NZ_CP048406.1|WP_065008527.1|6183039_6185340_+|CRISPR-associated-helicase/endonuclease-Cas3
MYYAHSTTEPVRSNWQPLDSHLIAVAGLAQQFGARIGIGRAAWLAGLLHDLGKYTPKFQARLSGAQERVDHSTAGAATIVQLAQAAKADDRIVAELIAYCIAGHHAGLPDKQGETFSTLSERLNAFSEAGLDPIWKSEIAPEIANLLPSFPNWEKTDKARAAFQLGFLGRMIFSCLIDADFKDTEQFYARTEGRQVDRNWPELQSILHGLIKSFDAHMDQKRNSDTSVNVLRTNILDHVRSRATEKPGLFTLTVPTGGGKTLASLGFALDQAKAHRLDRIIYAIPFTSIIDQAAAIFREIVGDGVVLEHHSAIEDEERRPREPPDADSTKADKDKLKLAMEDWAAPIVVTTNVQFFESLFAARTSRCRKLHNIANSVIVLDEAQTLPRQLLIPAVWALRELAENYGCSIVLCTATQPALDQRNFPGRHPAGLPLEGRELAPDPADLAEKLERVTLVHGGVMDDTAVLAELGKTNQGLVIVNSRKHALALYLQAKETGLQGLVHLTTRQYAAHRREVLAAVKQRLLNNEACRMIATSLVEAGVDLDFPRLWRAEAGLDQIAQAAGRCNREGRRPVEASIVTVFKAPENQPPPEIAGLSSDMARMMARHEKLLSPAAIEDFFGEVYWRVGPEGLDRGRNDRSAIVDKFRIGGSGTNFSYRSAAENFRMIESGMVPVIVARAEQAKAAIVKLRIETIPSGVIARDLQTYVVQVPPKARARLIACGHVKFAEERLRADQFAVLMTPGLYDPEVGLVWEDAEYLSQEAIGI
>NZ_CP048406.1|WP_082982395.1|6180190_6180880_-|ATP-binding-protein
MAYFRPRTNHDILEMKERGDAEGAALEYKSSRLFEQKNEKVFETLSKELTGFANAIGGVLIIGIEEDSERRISDIRPIQDPSRNETWLEDGLLSRISPSLQISIERIDVESGHLLVLDVPPSRNAPHQAADKRFYARRLFRIDPLLPFEVEDIRRRVSSLSSGASLSSPSKAERSPSRSRTKDSDIFSMFRSRLRASKTRVSHSNGRRAWTDLIPSLSGSFIPVRRETS
>NZ_CP048406.1|WP_065008525.1|6179681_6180149_-|hypothetical-protein
MDVHLQYTDEDGKQHQKTYTYYLKDFHSTYRIKSPNEEVLEQGIKRLENIERTLTNLSRDIKTMQESAFHPTGLNFSRTTLATLSSRAEMKWPGQFLTFQALAEVLEIDVESALRIQNEIFGASHYQGGVNKPLEDIDLPDDIKERIRQRLILPG
>NZ_CP048406.1|WP_065008552.1|6178342_6179308_-|toll/interleukin-1-receptor-domain-containing-protein
MTGVFFSYSHADEALRDQLEKQLSMLKRQGVIDTWHDRRIGAGQEIAQAIDEQINRDDIILLLVSADFLASNYCYDIEMKRAMERHEAQEAIVIPIILWACDWHHAPFGKLNAVPRDGKPITQWADIDEAFLQVAKAVREAADQRNKTAQSQAPATDASATSQPAPRTAEGPRSSNLRLAKSFTQRDKDRFQEEACEFMARFFENSLAELAERNPGIEGVFRRVDANRFFATLYRDGKDIAKATIYMGGDSFGRGINYVRGHTTASNTINESVNVEADDQTIYLTTTGMMHFGGQNEKKLSREGAAERYWENLIRPLQERW
>NZ_CP048406.1|WP_065008524.1|6177868_6178339_-|hypothetical-protein
MLAPEEFTAGTFASAPAGSLILPRNKHEASVIVGLLDGAPTALFLGDRFQFQYFPTAGSENWSGLIIPNVRVEIDESTAFDAAYGNSPLGTVVRAATQLSVYAKAERSFGHRAVPLVSNLPATYDGGVGFTKWHVVLGAGAEKRILLKIDVQTADQ
>NZ_CP048406.1|WP_065008551.1|6177067_6177718_-|hypothetical-protein
MALKAQVESNGYAFLPRHAGVADAALVAAALGVPIAPWDRTTVQQLVPRASSTPNTYSGIFGLGRFPFHTDLAHWLRPPPYLMLRCVRGFDDVPTLLVDGRSIVEAVTIDIVQRAVVRPRRPQSSEMRLLRIWETTDTGHLLRWDEVFLKPASLVGEVAFRKIREHLETVVPVPVALVDAGDTLIVDNWRMLHGRPAISAGREDRRLERVYLGSLN
>NZ_CP048406.1|WP_065008523.1|6176114_6177071_-|hypothetical-protein
MKRTINPGDLVAAWNPQALYDKAERYMQQAHGLDSDEWDHALWSGLALELLARAALANIHPALLAEPDRAGSNLISALGFNPIVKKFTPRSITVSEVFTRLAAMLPEFSAELESFGALHTGRRNAELHSGELGFDGVKGSSWQPKFYQTCAVLLASMGLTLEEFVGADEAKVAEAIIAAAADESAKAVKGDVEAHAQVWKAKSADERSILAAQAELWASRHAGHRVQCPACGSRALVVGGPVSAPVRKLAEDEIVEKQECLPSHFECIACGLKVNGLSRLAVVGLADRYTNTQVYDAAEYYAPAEDEWAGYEEDNNER
>NZ_CP048406.1|WP_065008537.1|6194244_6196491_-|cadmium-translocating-P-type-ATPase
MAATAPQTRYRVEGMDCAGCATKIDSALRRMHGVQDVNVSVTAGTMTVWHTAESDLAAIEKKVTGLGYSVAQLTSEAGQNAKPAGHGTKGGHDHAGHDHAGRHHAGTAKDGHDNGESLHGHDHTPATGPWWNSAKGRLSIASGAALAAAFAIHYVWPATRVWLFIAAMLIALVPIARRAVMAALAGIPFTIEMLMTIAAIGAVIIGAGEEAATVVFLFLVGELLEGVAAGKARSSIQSLTTLVPKTAFLEENGATREVPAEALGVGAVILVRPGDRIPADGKIIEGESAIDESPVSGESVPVRKGVDADVFAGTINGDGVLRITVTAAASDNTIARIVKLVEEAQESKAPTERFIDHFSRWYTPAVVAVGALVAVVPPMAFGDDWNEWIYKGLALLLIGCPCALVISVPAAIAASLSAGAKRGLLMKGGAVLEGLGKITAVALDKTGTLTQGKPVVTDVVAIEISEKEVLSLAAALETGSSHPLALAILRKAKADRVPVPPAAEAKALGGKGVVGRIGGKNVFLGSPIAGGEKVALPPEQAAYIAELNDQGKSVSVLLINDVLAGFIAMRDEPRLDAQAGLKALTDVGIRTVMLTGDNQRTAAAIGKHLDIEVRSELLPEDKQRIVGELKGQGLMVAKVGDGINDAPALAAADIGIAMGGGTDVALETADAAVLHGRVGDVAAMIKLSQATMANIKQNITMALGLKAVFLVTTVVGITGLWPAILADTGATVLVTANAMRLLRWKGGV
>NZ_CP048406.1|WP_065008538.1|6196561_6196984_+|helix-turn-helix-domain-containing-protein
MRSVPIGEAARQSGVKVPTIRYYEQIGLLPAPNRSEGNRRHYETSDLRRLAFIRHSRELGFGIEAIRTLLTLQDNPSQPCATADTIAQARLADVVQRIRSLTALKAELELMVEGCRHGKVGECRVIEVLADHSQCEHARH
>NZ_CP048406.1|WP_065008539.1|6197506_6198622_-|Fic-family-protein
MVWNWEQADWPHFTYDKEELEPLESEFLLRSGEFLGVFRHVGSDDRDQIRIDLISEEALKTSAIEGEYLNRESLQSSLRQQLGLGSENRRIPPAERGIAEMMADVYLHFGHALSHRTLYAWHKMVMSGELRIETIGNYRQHADVMQIVSNRLDKPKVHFEAPPSARVKAEMDAFTAWFNDTAPKGKTPLPALTRAGIAHLYFESIHPFEDGNGRIGRALCGNALAQSLGEPSLIALAYTIERHRKAYYDNLQASNKSNAVTNWLLYFANTVLEAQRVTLVRVEFSVAKAKFYERYRNQFNERQEKVIARMFREGIDGFKGGLSAENYIAITQASRATATRDLQDLVSKGAMTRTGERRHTRYALNILDERR
>NZ_CP048406.1|WP_065008540.1|6198918_6199947_-|LLM-class-flavin-dependent-oxidoreductase
MKNAFPRGLTFGIFDHLDEDGCEIARQYANRLSLAEACDQLGFYAYHLAEHHCTPHGRSPSPNLFLSSVVQRTRHLRVGPMVMLLALYHPLRAFEEICMLDQLSGGRVELGIGRGSLPVELGYFGIAAEAAPGHYTEASEILIKAMNGDTLSYRGRHFELNDVPLTLRSHQRPHPPTWIATNRPESASWAAASGANIACLGPASSVRRITDAFRACRERSADADERGPFLGMLRMVVIARSQTDAYALAAPAYERWLKSFRFLYDLNALQTPPNLPLSLDAAIESELCVVGTASSARQALLDQLEEAGANYLLCQLAFGNLSLDASLYTARTIQSEIMARVT
>NZ_CP048406.1|WP_065008541.1|6200033_6201182_-|histidinol-phosphate-transaminase
MSDAKLQTVLSSLSQVAGQLDVLLSDKPAPDPCCVKLNTNENPFPLPKAIMQSAMAALERQYLYPEDDNVSLRQAASEAYGVSKDQVIAGNGSSELLGLIYRAFLVPGDRMAMMSPGFSFNRKLARLQGAQFLEIGWCADHSLPVEDLLSGPAKDAKFILLANPNNPTGTFVPVADVERLVSQSDRLIVLDEAYVDFAPDNGLHLLDRYPNLLILRTFSKSYATAGIRVGFGLGHPEVIGRLRDLQNVFNMNVIGQAVGISVLGHRAAYAENHKHIKHERQRVTVALSKLGFSVIPSHANFLLARVPAGQEGSWWQAALERQKILVAFFEDAGLENYIRISIGTKNEMDEFLEVATEIAATAKETIPLCRPSAAAASALTSR
>NZ_CP048406.1|WP_065008553.1|6201416_6203198_-|nif-specific-transcriptional-activator-NifA
MSDQDNGRQSEDSAEQTSSSCTSLHDTKRDDSEPAILPSRASALAGIYEISKALTAPSGLEVRLAKVVDLLRSFLQMRHGIISLFDGDGELEIIAGAGRTESCSERCRTYLPRNAIDQVLATDKPLATENIAVHPAFAADMDVLGASDGIPVSFVGVPIRVDANVVGTLTIDHVLHHGSRVWLDYSLCLLPLIANLVGQAVKSHRSFEGDREQPMAKQDSLPKQKRLAPQRNTHVEGMIGDSLALRGLLEKVALVAKAKIAVLLRGESGTGKELVAKAIHELSPRAKRPFIKLNCAALPETVLESELFGHEKGAFTSAFNSRKGRFELADKGTLFLDEIGEISASFQAKLLRVLQEQEFERVGGNQTIKVDVRIIAATNKNLEEAVARNEFRADLYYRISVVPLLVPALRERRSDIPLLAAEFLKNFNDENGLMLTFDPSAIEVLVNCDFPGNIRELENCVYRTAVLAAGPSIGKDDFACCQDKCFAEALHNCRLGKVALQPSPIGPLPLVRAMPPAAGVSSAAVPPPSATEGQPPLDPVGVVHSARMADAERVIQAMERCGWVQAKAARLLGLTPRQIGYVLRKYGIEIKRL
>NZ_CP048406.1|WP_163603096.1|6204355_6205654_+|dicarboxylate/amino-acid:cation-symporter
MVSPIRSAGPAPRKAFCAQPYIQVLTAIALGVAVGYFYPDVGESLKPLGDAFIKLVKMIIAPVIFLTVTTGIAGMNDLKKVGRVAGKAMIYFLTFSSLALIVGLIVANVVQPGAGLNIDPASLDAQAVKGYAAKVHEQSVTGFLMNIIPSTIVSAFAEGDIMQVLFFSVLFGIALAMVGDTGKPVLSLLQALLAPVFKLVGILMRAAPVGAFGAMAFTIGKYGIGSVANLAMLVATFYFTAFLFVFGILGAVCRYNGFSIFSLVRYIKEELLLVLATSSSEAALPSLIAKMENAGAKRSVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATNTHLSIPDQIFLLLVAMLSSKGAAGITGAGFITLAATLSVIPSVPVAGMALILGVDRFMSECRALTNVIGNAVASLVVARWEGELDETRMKAAFYGSLPRD
>NZ_CP048406.1|WP_065011499.1|6205936_6207001_+|LacI-family-transcriptional-regulator
MTERQPIKIGATAKRPTIADLAREAGVSVATVDRVLNARLPVREETARRVHHAAHAIGYHAAGLIKQRMGKDLPRYRLGFILRKPAQHFYQEFAREVEASVSSAHCFHGIPLIEFAPSHLPGDLTALLKDLGSRCHAIAMVAPDHPKITAAVEELKAKGIPVFSLLSDFAAGVREGYIGLNNRSVGRTAAWMFSKVAKRSGKVAVFVGSHRFQGHELRESGFRSYFRENEPAFEVLDTLVNLEKRQITYEALLDLMQREPELVGFYMAGGGMEGAISALREEGKGQDLVAIVNEITPESREALADDIITMAVATPLRRLCQELMLLMDRAIRTGTAETPGQTFLPFDIYLPENI
>NZ_CP048406.1|WP_156768530.1|6207449_6207617_+|hypothetical-protein
MIAWLPERQPGVRPSAFPNLTVDITAMIGLENAPSIEPKSGLAGLQEEANTSEAA
>NZ_CP048406.1|WP_065011504.1|6208659_6209121_+|transposase
MANPLDAEPEITATQPAAKVEGPQKKKAKRSPKAKAEPRPPARKAPNAASQAEEAPAATVRTGRKIYSEKERAQMLALIQKSISGGATLKSAVKQAGISEQTYYQWKKPALPASVGDDLKDLVALEEENKRLKSLLAERLRKENAELKRKLGF

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Crispr_ID: NZ_CP048406_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_10

6192747-6193133

TypeI

Consensus_repeat	Method
GGGGGCGTGGATCGAAAC	CRT
GGGGCGTGGATCGAAAC	PILER-CR

6 spacers

cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP048406_10

>merge|NZ_CP048406|10|6192747-6193133|CRT,PILER-CR
GCCCCCGTGGATCGAAACCGCGTAGGCCCGATGGCAAGATCAAAAGTTCTCGTCGCCCCGGCGTGGATCGAAACTTATTTAACCGTGCGGCTTTTCCGGATCCGGAAGGTCGGGGGCGTGGATCGAAACGTTGCGCTCCTCCAATTCCTGCAGGCGCCGCTGCGTCGCCCCTCACACGGGGGCGTGGATCGAAACCTCCTGAAGGAACGCAAGCCGCTCCGTCCGCTCGTCGCCCCGCACACGGGGGGCGTGGATTGAAACTGGTACGACCCGGAGGATCCGGCATTCTTCACCGGTCGCCCCTCGGGGCGTTGATCGAAACTCGTTCTAAACCGGAACGGTACCAATTGAGATCGTCGCCCCTCACACGGGGGCGTGGATCGAAAC

>NZ_CP048406|10|3|6192747-6193133|CRT
GCCCCCGTGGATCGAAAC	CGCGTAGGCCCGATGGCAAGATCAAAAGTTCTCGTCGC
CCCGGCGTGGATCGAAAC	TTATTTAACCGTGCGGCTTTTCCGGATCCGGAAGGTC
GGGGGCGTGGATCGAAAC	GTTGCGCTCCTCCAATTCCTGCAGGCGCCGCTGCGTCGCCCCTCACAC
GGGGGCGTGGATCGAAAC	CTCCTGAAGGAACGCAAGCCGCTCCGTCCGCTCGTCGCCCCGCACACG
GGGGGCGTGGATTGAAAC	TGGTACGACCCGGAGGATCCGGCATTCTTCACCGGTCGCCCCT
CGGGGCGTTGATCGAAAC	TCGTTCTAAACCGGAACGGTACCAATTGAGATCGTCGCCCCTCACAC
GGGGGCGTGGATCGAAAC

>NZ_CP048406|10|5|6192806-6193133|PILER-CR
GGCGTGGATCGAAACTT	ATTTAACCGTGCGGCTTTTCCGGATCCGGAAGGTCGGG
GGCGTGGATCGAAACGT	TGCGCTCCTCCAATTCCTGCAGGCGCCGCTGCGTCGCCCCTCACACGGG
GGCGTGGATCGAAACCT	CCTGAAGGAACGCAAGCCGCTCCGTCCGCTCGTCGCCCCGCACACGGGG
GGCGTGGATTGAAACTG	GTACGACCCGGAGGATCCGGCATTCTTCACCGGTCGCCCCTCGG
GGCGTTGATCGAAACTC	GTTCTAAACCGGAACGGTACCAATTGAGATCGTCGCCCCTCACACGGG
GGCGTGGATCGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_065008552.1\|6178342_6179308_-\|toll/interleukin-1-receptor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379328
NZ_CP048406.1\|WP_156768530.1\|6207449_6207617_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_082982395.1\|6180190_6180880_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|377306
NZ_CP048406.1\|WP_065008541.1\|6200033_6201182_-\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|223157
NZ_CP048406.1\|WP_065008525.1\|6179681_6180149_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008553.1\|6201416_6203198_-\|nif-specific-transcriptional-activator-NifA	unknown	unknown	gnl\|CDD\|273817
NZ_CP048406.1\|WP_065008540.1\|6198918_6199947_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225052
NZ_CP048406.1\|WP_065011499.1\|6205936_6207001_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380530
NZ_CP048406.1\|WP_065008530.1\|6187793_6188750_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NZ_CP048406.1\|WP_065008537.1\|6194244_6196491_-\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319846
NZ_CP048406.1\|WP_065008551.1\|6177067_6177718_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238154
NZ_CP048406.1\|WP_163603096.1\|6204355_6205654_+\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|234968
NZ_CP048406.1\|WP_065008529.1\|6186051_6187797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|378245
NZ_CP048406.1\|WP_065008539.1\|6197506_6198622_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP048406.1\|WP_065011504.1\|6208659_6209121_+\|transposase	unknown	unknown	gnl\|CDD\|366690
NZ_CP048406.1\|WP_065008527.1\|6183039_6185340_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_CP048406.1\|WP_065008528.1\|6185386_6186055_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NZ_CP048406.1\|WP_065008524.1\|6177868_6178339_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008538.1\|6196561_6196984_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|133412
NZ_CP048406.1\|WP_065008523.1\|6176114_6177071_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_065008552.1\|6178342_6179308_-\|toll/interleukin-1-receptor-domain-containing-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	3.25497e-14
NZ_CP048406.1\|WP_082982395.1\|6180190_6180880_-\|ATP-binding-protein	gnl\|CDD\|377306	pfam04326, AlbA_2, Putative DNA-binding domain. This family belongs to the AlbA clan of DNA-binding domains.	4.64389e-17
NZ_CP048406.1\|WP_065008541.1\|6200033_6201182_-\|histidinol-phosphate-transaminase	gnl\|CDD\|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	3.35024e-109
NZ_CP048406.1\|WP_065008553.1\|6201416_6203198_-\|nif-specific-transcriptional-activator-NifA	gnl\|CDD\|273817	TIGR01817, Nif-specific_regulatory_protein, Nif-specific regulatory protein. This model represents NifA, a DNA-binding regulatory protein for nitrogen fixation. The model produces scores between the trusted and noise cutoffs for a well-described NifA homolog in Aquifex aeolicus (which lacks nitrogenase), for transcriptional activators of alternative nitrogenases (VFe or FeFe instead of MoFe), and truncated forms. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, DNA interactions].	0
NZ_CP048406.1\|WP_065011499.1\|6205936_6207001_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|380530	cd06307, PBP1_sugar_binding, periplasmic sugar-binding domain of uncharacterized transport systems. Periplasmic sugar-binding domain of uncharacterized transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes.	6.49906e-90
NZ_CP048406.1\|WP_065011504.1\|6208659_6209121_+\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	7.6748e-07
NZ_CP048406.1\|WP_065008540.1\|6198918_6199947_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	5.04199e-44
NZ_CP048406.1\|WP_065008537.1\|6194244_6196491_-\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319846	cd07546, P-type_ATPase_Pb_Zn_Cd2-like, P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP048406.1\|WP_065008530.1\|6187793_6188750_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.93741e-145
NZ_CP048406.1\|WP_163603096.1\|6204355_6205654_+\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|234968	PRK01663, PRK01663, C4-dicarboxylate transporter DctA; Reviewed.	0
NZ_CP048406.1\|WP_065008529.1\|6186051_6187797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NZ_CP048406.1\|WP_065008539.1\|6197506_6198622_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	2.88204e-55
NZ_CP048406.1\|WP_065008528.1\|6185386_6186055_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	5.93317e-117
NZ_CP048406.1\|WP_065008551.1\|6177067_6177718_-\|hypothetical-protein	gnl\|CDD\|238154	cd00250, CAS_like, Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases catalyze a hydroxylation reaction, which leads to the incorporation of an oxygen atom from dioxygen into a hydroxyl group and conversion of 2OG to succinate and CO2.	1.60343e-12
NZ_CP048406.1\|WP_065008538.1\|6196561_6196984_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|133412	cd04785, HTH_CadR-PbrR-like, Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators. Helix-turn-helix (HTH) CadR- and PbrR-like transcription regulators. CadR and PbrR regulate expression of the cadmium and lead resistance operons, respectively. These proteins are comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains have three conserved cysteines which comprise a putative metal binding site. Some members in this group have a histidine-rich C-terminal extension. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	4.89561e-60
NZ_CP048406.1\|WP_065008527.1\|6183039_6185340_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	6.6951e-55

>NZ_CP048406.1|WP_065008530.1|6187793_6188750_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MNALSNRYDFVLLFDVSKGNPNGDPDAGNMPRLDPETNHGLVSDVSLKRKVRNYVEFARGEHQSYNIYVKEGAILNEQHRKAYVALRPDDGKAAKDAKLNPKDDDEGRALTRFMCANFFDVRTFGAVMSTGINAGQVRGPVQMTFASSIEPIVPQEISITRMAATNEAEKKQRVEGSEEGNNRIDNRTMGRKHIVPYGLYRAHGFVSAKLAERTGFSDTDLDLLFEALSTMFEHDRSAARGEMASRKLVVFKHANALGNAPAHALFDRLRIGRNIDGLFRDVHDSGIDNYPPARKYSDYKIEIDRDGMPEGVEIIERL
>NZ_CP048406.1|WP_065008529.1|6186051_6187797_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSILASLAKAYDRLPDAPPFGYSTEKIGFVISLNQDGSVASVTDLRDGTGKKKLPRMMQVPQPTKRTAGIAPNFLWDKTSYVLGVTAGEGKRTADEHAAFVKRHRVALEDSDDTGLLALSLFLEGWAPERFVEPTWPDEMKDQNVVFALDSERRQDGYLHDRPAAKALWMARSGGGDAASICLVTGSNGAVARLHPAIKGVWGAQSSGASIVSFNLDAFMSYEHEQGDNAPVSESAAFKYSTALNTFLAGKTNRIQVGDTSTVFWADASNAEVARTAEGTFGAMFSDVDEVTQAGKVGDILARIRNGLPLKEIAPELENGVRFYVLGLAPNAARLSIRFWFENDFGVLAKNYQRFVAEMEVDPPPRDANPALWKYLAETAVLGKRENVPPNLAGEWMRSILTGSRYPLTLLSTVLMRIRADGEVNALRVSILKALLVRNFNKAIGEAPVSFQPENRNKGYLLGRLFAAYEQIQTAALGRNVNATIKDKFYSSASAQPRKVFPLLDRGSANHLSKVGKQRPGQRVNLEKAIGAILERMSPDSDPFPASLSAEEQALFGLGYYHQRGEFFRKPETVDTQDAAS
>NZ_CP048406.1|WP_065008528.1|6185386_6186055_+|type-I-C-CRISPR-associated-protein-Cas5
MSFGIMLKVSGSHACFTRPEMKVERVSYDVMTPSAARGILEAIHWKPAIRWVVDAIHVLNVIRFQSIRRNEVGSKVSARYAKTAMNRGSLEGLHLLVDEDRQQRAATVLVDVAYLIEAHFELTDKAGPDDNEGKHLDTFNRRAARGQCFHQPCLGTREFAAAFELLPPGAPLPDAIKETRDLGFMLWDIDHGAPDKPSLFFRAGLNNGVMRVPAPNSSEIRR
>NZ_CP048406.1|WP_065008527.1|6183039_6185340_+|CRISPR-associated-helicase/endonuclease-Cas3
MYYAHSTTEPVRSNWQPLDSHLIAVAGLAQQFGARIGIGRAAWLAGLLHDLGKYTPKFQARLSGAQERVDHSTAGAATIVQLAQAAKADDRIVAELIAYCIAGHHAGLPDKQGETFSTLSERLNAFSEAGLDPIWKSEIAPEIANLLPSFPNWEKTDKARAAFQLGFLGRMIFSCLIDADFKDTEQFYARTEGRQVDRNWPELQSILHGLIKSFDAHMDQKRNSDTSVNVLRTNILDHVRSRATEKPGLFTLTVPTGGGKTLASLGFALDQAKAHRLDRIIYAIPFTSIIDQAAAIFREIVGDGVVLEHHSAIEDEERRPREPPDADSTKADKDKLKLAMEDWAAPIVVTTNVQFFESLFAARTSRCRKLHNIANSVIVLDEAQTLPRQLLIPAVWALRELAENYGCSIVLCTATQPALDQRNFPGRHPAGLPLEGRELAPDPADLAEKLERVTLVHGGVMDDTAVLAELGKTNQGLVIVNSRKHALALYLQAKETGLQGLVHLTTRQYAAHRREVLAAVKQRLLNNEACRMIATSLVEAGVDLDFPRLWRAEAGLDQIAQAAGRCNREGRRPVEASIVTVFKAPENQPPPEIAGLSSDMARMMARHEKLLSPAAIEDFFGEVYWRVGPEGLDRGRNDRSAIVDKFRIGGSGTNFSYRSAAENFRMIESGMVPVIVARAEQAKAAIVKLRIETIPSGVIARDLQTYVVQVPPKARARLIACGHVKFAEERLRADQFAVLMTPGLYDPEVGLVWEDAEYLSQEAIGI
>NZ_CP048406.1|WP_082982395.1|6180190_6180880_-|ATP-binding-protein
MAYFRPRTNHDILEMKERGDAEGAALEYKSSRLFEQKNEKVFETLSKELTGFANAIGGVLIIGIEEDSERRISDIRPIQDPSRNETWLEDGLLSRISPSLQISIERIDVESGHLLVLDVPPSRNAPHQAADKRFYARRLFRIDPLLPFEVEDIRRRVSSLSSGASLSSPSKAERSPSRSRTKDSDIFSMFRSRLRASKTRVSHSNGRRAWTDLIPSLSGSFIPVRRETS
>NZ_CP048406.1|WP_065008525.1|6179681_6180149_-|hypothetical-protein
MDVHLQYTDEDGKQHQKTYTYYLKDFHSTYRIKSPNEEVLEQGIKRLENIERTLTNLSRDIKTMQESAFHPTGLNFSRTTLATLSSRAEMKWPGQFLTFQALAEVLEIDVESALRIQNEIFGASHYQGGVNKPLEDIDLPDDIKERIRQRLILPG
>NZ_CP048406.1|WP_065008552.1|6178342_6179308_-|toll/interleukin-1-receptor-domain-containing-protein
MTGVFFSYSHADEALRDQLEKQLSMLKRQGVIDTWHDRRIGAGQEIAQAIDEQINRDDIILLLVSADFLASNYCYDIEMKRAMERHEAQEAIVIPIILWACDWHHAPFGKLNAVPRDGKPITQWADIDEAFLQVAKAVREAADQRNKTAQSQAPATDASATSQPAPRTAEGPRSSNLRLAKSFTQRDKDRFQEEACEFMARFFENSLAELAERNPGIEGVFRRVDANRFFATLYRDGKDIAKATIYMGGDSFGRGINYVRGHTTASNTINESVNVEADDQTIYLTTTGMMHFGGQNEKKLSREGAAERYWENLIRPLQERW
>NZ_CP048406.1|WP_065008524.1|6177868_6178339_-|hypothetical-protein
MLAPEEFTAGTFASAPAGSLILPRNKHEASVIVGLLDGAPTALFLGDRFQFQYFPTAGSENWSGLIIPNVRVEIDESTAFDAAYGNSPLGTVVRAATQLSVYAKAERSFGHRAVPLVSNLPATYDGGVGFTKWHVVLGAGAEKRILLKIDVQTADQ
>NZ_CP048406.1|WP_065008551.1|6177067_6177718_-|hypothetical-protein
MALKAQVESNGYAFLPRHAGVADAALVAAALGVPIAPWDRTTVQQLVPRASSTPNTYSGIFGLGRFPFHTDLAHWLRPPPYLMLRCVRGFDDVPTLLVDGRSIVEAVTIDIVQRAVVRPRRPQSSEMRLLRIWETTDTGHLLRWDEVFLKPASLVGEVAFRKIREHLETVVPVPVALVDAGDTLIVDNWRMLHGRPAISAGREDRRLERVYLGSLN
>NZ_CP048406.1|WP_065008523.1|6176114_6177071_-|hypothetical-protein
MKRTINPGDLVAAWNPQALYDKAERYMQQAHGLDSDEWDHALWSGLALELLARAALANIHPALLAEPDRAGSNLISALGFNPIVKKFTPRSITVSEVFTRLAAMLPEFSAELESFGALHTGRRNAELHSGELGFDGVKGSSWQPKFYQTCAVLLASMGLTLEEFVGADEAKVAEAIIAAAADESAKAVKGDVEAHAQVWKAKSADERSILAAQAELWASRHAGHRVQCPACGSRALVVGGPVSAPVRKLAEDEIVEKQECLPSHFECIACGLKVNGLSRLAVVGLADRYTNTQVYDAAEYYAPAEDEWAGYEEDNNER
>NZ_CP048406.1|WP_065008537.1|6194244_6196491_-|cadmium-translocating-P-type-ATPase
MAATAPQTRYRVEGMDCAGCATKIDSALRRMHGVQDVNVSVTAGTMTVWHTAESDLAAIEKKVTGLGYSVAQLTSEAGQNAKPAGHGTKGGHDHAGHDHAGRHHAGTAKDGHDNGESLHGHDHTPATGPWWNSAKGRLSIASGAALAAAFAIHYVWPATRVWLFIAAMLIALVPIARRAVMAALAGIPFTIEMLMTIAAIGAVIIGAGEEAATVVFLFLVGELLEGVAAGKARSSIQSLTTLVPKTAFLEENGATREVPAEALGVGAVILVRPGDRIPADGKIIEGESAIDESPVSGESVPVRKGVDADVFAGTINGDGVLRITVTAAASDNTIARIVKLVEEAQESKAPTERFIDHFSRWYTPAVVAVGALVAVVPPMAFGDDWNEWIYKGLALLLIGCPCALVISVPAAIAASLSAGAKRGLLMKGGAVLEGLGKITAVALDKTGTLTQGKPVVTDVVAIEISEKEVLSLAAALETGSSHPLALAILRKAKADRVPVPPAAEAKALGGKGVVGRIGGKNVFLGSPIAGGEKVALPPEQAAYIAELNDQGKSVSVLLINDVLAGFIAMRDEPRLDAQAGLKALTDVGIRTVMLTGDNQRTAAAIGKHLDIEVRSELLPEDKQRIVGELKGQGLMVAKVGDGINDAPALAAADIGIAMGGGTDVALETADAAVLHGRVGDVAAMIKLSQATMANIKQNITMALGLKAVFLVTTVVGITGLWPAILADTGATVLVTANAMRLLRWKGGV
>NZ_CP048406.1|WP_065008538.1|6196561_6196984_+|helix-turn-helix-domain-containing-protein
MRSVPIGEAARQSGVKVPTIRYYEQIGLLPAPNRSEGNRRHYETSDLRRLAFIRHSRELGFGIEAIRTLLTLQDNPSQPCATADTIAQARLADVVQRIRSLTALKAELELMVEGCRHGKVGECRVIEVLADHSQCEHARH
>NZ_CP048406.1|WP_065008539.1|6197506_6198622_-|Fic-family-protein
MVWNWEQADWPHFTYDKEELEPLESEFLLRSGEFLGVFRHVGSDDRDQIRIDLISEEALKTSAIEGEYLNRESLQSSLRQQLGLGSENRRIPPAERGIAEMMADVYLHFGHALSHRTLYAWHKMVMSGELRIETIGNYRQHADVMQIVSNRLDKPKVHFEAPPSARVKAEMDAFTAWFNDTAPKGKTPLPALTRAGIAHLYFESIHPFEDGNGRIGRALCGNALAQSLGEPSLIALAYTIERHRKAYYDNLQASNKSNAVTNWLLYFANTVLEAQRVTLVRVEFSVAKAKFYERYRNQFNERQEKVIARMFREGIDGFKGGLSAENYIAITQASRATATRDLQDLVSKGAMTRTGERRHTRYALNILDERR
>NZ_CP048406.1|WP_065008540.1|6198918_6199947_-|LLM-class-flavin-dependent-oxidoreductase
MKNAFPRGLTFGIFDHLDEDGCEIARQYANRLSLAEACDQLGFYAYHLAEHHCTPHGRSPSPNLFLSSVVQRTRHLRVGPMVMLLALYHPLRAFEEICMLDQLSGGRVELGIGRGSLPVELGYFGIAAEAAPGHYTEASEILIKAMNGDTLSYRGRHFELNDVPLTLRSHQRPHPPTWIATNRPESASWAAASGANIACLGPASSVRRITDAFRACRERSADADERGPFLGMLRMVVIARSQTDAYALAAPAYERWLKSFRFLYDLNALQTPPNLPLSLDAAIESELCVVGTASSARQALLDQLEEAGANYLLCQLAFGNLSLDASLYTARTIQSEIMARVT
>NZ_CP048406.1|WP_065008541.1|6200033_6201182_-|histidinol-phosphate-transaminase
MSDAKLQTVLSSLSQVAGQLDVLLSDKPAPDPCCVKLNTNENPFPLPKAIMQSAMAALERQYLYPEDDNVSLRQAASEAYGVSKDQVIAGNGSSELLGLIYRAFLVPGDRMAMMSPGFSFNRKLARLQGAQFLEIGWCADHSLPVEDLLSGPAKDAKFILLANPNNPTGTFVPVADVERLVSQSDRLIVLDEAYVDFAPDNGLHLLDRYPNLLILRTFSKSYATAGIRVGFGLGHPEVIGRLRDLQNVFNMNVIGQAVGISVLGHRAAYAENHKHIKHERQRVTVALSKLGFSVIPSHANFLLARVPAGQEGSWWQAALERQKILVAFFEDAGLENYIRISIGTKNEMDEFLEVATEIAATAKETIPLCRPSAAAASALTSR
>NZ_CP048406.1|WP_065008553.1|6201416_6203198_-|nif-specific-transcriptional-activator-NifA
MSDQDNGRQSEDSAEQTSSSCTSLHDTKRDDSEPAILPSRASALAGIYEISKALTAPSGLEVRLAKVVDLLRSFLQMRHGIISLFDGDGELEIIAGAGRTESCSERCRTYLPRNAIDQVLATDKPLATENIAVHPAFAADMDVLGASDGIPVSFVGVPIRVDANVVGTLTIDHVLHHGSRVWLDYSLCLLPLIANLVGQAVKSHRSFEGDREQPMAKQDSLPKQKRLAPQRNTHVEGMIGDSLALRGLLEKVALVAKAKIAVLLRGESGTGKELVAKAIHELSPRAKRPFIKLNCAALPETVLESELFGHEKGAFTSAFNSRKGRFELADKGTLFLDEIGEISASFQAKLLRVLQEQEFERVGGNQTIKVDVRIIAATNKNLEEAVARNEFRADLYYRISVVPLLVPALRERRSDIPLLAAEFLKNFNDENGLMLTFDPSAIEVLVNCDFPGNIRELENCVYRTAVLAAGPSIGKDDFACCQDKCFAEALHNCRLGKVALQPSPIGPLPLVRAMPPAAGVSSAAVPPPSATEGQPPLDPVGVVHSARMADAERVIQAMERCGWVQAKAARLLGLTPRQIGYVLRKYGIEIKRL
>NZ_CP048406.1|WP_163603096.1|6204355_6205654_+|dicarboxylate/amino-acid:cation-symporter
MVSPIRSAGPAPRKAFCAQPYIQVLTAIALGVAVGYFYPDVGESLKPLGDAFIKLVKMIIAPVIFLTVTTGIAGMNDLKKVGRVAGKAMIYFLTFSSLALIVGLIVANVVQPGAGLNIDPASLDAQAVKGYAAKVHEQSVTGFLMNIIPSTIVSAFAEGDIMQVLFFSVLFGIALAMVGDTGKPVLSLLQALLAPVFKLVGILMRAAPVGAFGAMAFTIGKYGIGSVANLAMLVATFYFTAFLFVFGILGAVCRYNGFSIFSLVRYIKEELLLVLATSSSEAALPSLIAKMENAGAKRSVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATNTHLSIPDQIFLLLVAMLSSKGAAGITGAGFITLAATLSVIPSVPVAGMALILGVDRFMSECRALTNVIGNAVASLVVARWEGELDETRMKAAFYGSLPRD
>NZ_CP048406.1|WP_065011499.1|6205936_6207001_+|LacI-family-transcriptional-regulator
MTERQPIKIGATAKRPTIADLAREAGVSVATVDRVLNARLPVREETARRVHHAAHAIGYHAAGLIKQRMGKDLPRYRLGFILRKPAQHFYQEFAREVEASVSSAHCFHGIPLIEFAPSHLPGDLTALLKDLGSRCHAIAMVAPDHPKITAAVEELKAKGIPVFSLLSDFAAGVREGYIGLNNRSVGRTAAWMFSKVAKRSGKVAVFVGSHRFQGHELRESGFRSYFRENEPAFEVLDTLVNLEKRQITYEALLDLMQREPELVGFYMAGGGMEGAISALREEGKGQDLVAIVNEITPESREALADDIITMAVATPLRRLCQELMLLMDRAIRTGTAETPGQTFLPFDIYLPENI
>NZ_CP048406.1|WP_156768530.1|6207449_6207617_+|hypothetical-protein
MIAWLPERQPGVRPSAFPNLTVDITAMIGLENAPSIEPKSGLAGLQEEANTSEAA
>NZ_CP048406.1|WP_065011504.1|6208659_6209121_+|transposase
MANPLDAEPEITATQPAAKVEGPQKKKAKRSPKAKAEPRPPARKAPNAASQAEEAPAATVRTGRKIYSEKERAQMLALIQKSISGGATLKSAVKQAGISEQTYYQWKKPALPASVGDDLKDLVALEEENKRLKSLLAERLRKENAELKRKLGF

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Crispr_ID: NZ_CP048406_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP048406_11

6259105-6259204

Orphan

Consensus_repeat	Method
GTTGGTCTGCGGCGTAGGCATCCAACTGCAACTCATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP048406_11

>merge|NZ_CP048406|11|6259105-6259204|CRISPRCasFinder
GTTGGTCTGCGGCGTAGGCATCCAACTGCAACTCATTCGGATTAAAGAGACCTGATGAGTTCCGTTGGTCTGCGGCGTAGGCATCCAACTGCAACTCATT

>NZ_CP048406|11|6|6259105-6259204|CRISPRCasFinder
GTTGGTCTGCGGCGTAGGCATCCAACTGCAACTCATT	CGGATTAAAGAGACCTGATGAGTTCC
GTTGGTCTGCGGCGTAGGCATCCAACTGCAACTCATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP048406.1\|WP_095780357.1\|6256428_6257166_-\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|171820
NZ_CP048406.1\|WP_065010996.1\|6263179_6264382_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP048406.1\|WP_065010676.1\|6255360_6255951_-\|NodA-family-N-acyltransferase	unknown	unknown	gnl\|CDD\|179111
NZ_CP048406.1\|WP_065010993.1\|6266062_6266908_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187648
NZ_CP048406.1\|WP_065011000.1\|6268399_6269398_+\|farnesyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|182567
NZ_CP048406.1\|WP_082982652.1\|6273537_6274569_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_082982604.1\|6247555_6248866_-\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NZ_CP048406.1\|WP_141246637.1\|6250247_6250478_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP048406.1\|WP_065008438.1\|6258685_6258967_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|223314
NZ_CP048406.1\|WP_065010673.1\|6252058_6253159_-\|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|224014
NZ_CP048406.1\|WP_065010995.1\|6264476_6265766_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP048406.1\|WP_065010989.1\|6272214_6273261_+\|type-2-isopentenyl-diphosphate-Delta-isomerase	unknown	unknown	gnl\|CDD\|235465
NZ_CP048406.1\|WP_065010994.1\|6265767_6266076_+\|ferredoxin	unknown	unknown	gnl\|CDD\|379198
NZ_CP048406.1\|WP_065010672.1\|6251017_6251986_-\|GDP-L-fucose-synthase	unknown	unknown	gnl\|CDD\|187550
NZ_CP048406.1\|WP_065010992.1\|6266907_6268251_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP048406.1\|WP_065008437.1\|6257476_6258685_-\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	unknown	unknown	gnl\|CDD\|238430
NZ_CP048406.1\|WP_065010674.1\|6253301_6254291_-\|nodulation-protein-NodZ	unknown	unknown	gnl\|CDD\|283486
NZ_CP048406.1\|WP_065010670.1\|6249725_6250181_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP048406.1\|WP_065010990.1\|6269681_6271232_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215321
NZ_CP048406.1\|WP_065010997.1\|6261930_6263163_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035

Protein	Function_ID	Function_description	E-value
NZ_CP048406.1\|WP_095780357.1\|6256428_6257166_-\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|171820	PRK12936, PRK12936, 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed.	2.69864e-169
NZ_CP048406.1\|WP_065010996.1\|6263179_6264382_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.18037e-92
NZ_CP048406.1\|WP_065010676.1\|6255360_6255951_-\|NodA-family-N-acyltransferase	gnl\|CDD\|179111	PRK00756, PRK00756, acyltransferase NodA; Provisional.	4.38617e-140
NZ_CP048406.1\|WP_065010993.1\|6266062_6266908_+\|SDR-family-oxidoreductase	gnl\|CDD\|187648	cd08944, SDR_c12, classical (c) SDR, subgroup 12. These are classical SDRs, with the canonical active site tetrad and glycine-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.50158e-107
NZ_CP048406.1\|WP_082982604.1\|6247555_6248866_-\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	3.02016e-30
NZ_CP048406.1\|WP_065010992.1\|6266907_6268251_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	6.6193e-61
NZ_CP048406.1\|WP_065008438.1\|6258685_6258967_-\|acyl-carrier-protein	gnl\|CDD\|223314	COG0236, AcpP, Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	3.09466e-08
NZ_CP048406.1\|WP_065010673.1\|6252058_6253159_-\|GDP-mannose-4,6-dehydratase	gnl\|CDD\|224014	COG1089, Gmd, GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane].	0
NZ_CP048406.1\|WP_065010995.1\|6264476_6265766_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	5.77992e-88
NZ_CP048406.1\|WP_065010989.1\|6272214_6273261_+\|type-2-isopentenyl-diphosphate-Delta-isomerase	gnl\|CDD\|235465	PRK05437, PRK05437, isopentenyl pyrophosphate isomerase; Provisional.	1.02587e-160
NZ_CP048406.1\|WP_065010994.1\|6265767_6266076_+\|ferredoxin	gnl\|CDD\|379198	pfam13459, Fer4_15, 4Fe-4S single cluster domain.	2.58522e-11
NZ_CP048406.1\|WP_065010672.1\|6251017_6251986_-\|GDP-L-fucose-synthase	gnl\|CDD\|187550	cd05239, GDP_FS_SDR_e, GDP-fucose synthetase, extended (e) SDRs. GDP-fucose synthetase (aka 3, 5-epimerase-4-reductase) acts in the NADP-dependent synthesis of GDP-fucose from GDP-mannose. Two activities have been proposed for the same active site: epimerization and reduction. Proteins in this subgroup are extended SDRs, which have a characteristic active site tetrad and an NADP-binding motif, [AT]GXXGXXG, that is a close match to the archetypical form. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.61029e-156
NZ_CP048406.1\|WP_065011000.1\|6268399_6269398_+\|farnesyl-diphosphate-synthase	gnl\|CDD\|182567	PRK10581, PRK10581, (2E,6E)-farnesyl diphosphate synthase.	7.43604e-75
NZ_CP048406.1\|WP_065008437.1\|6257476_6258685_-\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	gnl\|CDD\|238430	cd00834, KAS_I_II, Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.	3.66914e-172
NZ_CP048406.1\|WP_065010674.1\|6253301_6254291_-\|nodulation-protein-NodZ	gnl\|CDD\|283486	pfam05830, NodZ, Nodulation protein Z (NodZ). The nodulation genes of Rhizobia are regulated by the nodD gene product in response to host-produced flavonoids and appear to encode enzymes involved in the production of a lipo-chitose signal molecule required for infection and nodule formation. NodZ is required for the addition of a 2-O-methylfucose residue to the terminal reducing N-acetylglucosamine of the nodulation signal. This substitution is essential for the biological activity of this molecule. Mutations in nodZ result in defective nodulation. nodZ represents a unique nodulation gene that is not under the control of NodD and yet is essential for the synthesis of an active nodulation signal.	0
NZ_CP048406.1\|WP_065010670.1\|6249725_6250181_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.58433e-07
NZ_CP048406.1\|WP_065010990.1\|6269681_6271232_+\|hypothetical-protein	gnl\|CDD\|215321	PLN02592, PLN02592, ent-copalyl diphosphate synthase.	3.41823e-16
NZ_CP048406.1\|WP_065010997.1\|6261930_6263163_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	7.92938e-88

>NZ_CP048406.1|WP_065008438.1|6258685_6258967_-|acyl-carrier-protein
MADQLATEIIATIKNRLESESGQGKSVSIIGEITTATELTSLGVDSLGLADLLWDVEQAYDIKIDMNAADAWSNLKNVGDMVEAVRGLLAKEV
>NZ_CP048406.1|WP_065008437.1|6257476_6258685_-|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein
MDRRVVITGMGGLCGLGNNAASIWKEMREGRSAIRPMVSSELHEMKGIVGTEIKELPEHDIGRNQLVSMDRVGLLAVLAAREAMQHAGLSCDQGNPNRFGATVGVCGWGWGTVEDTYRALLLGGAKRAGIYTAPRGLPSAAASQVSMSLGLRGPVFAIASACASANHAIASAADQIRLGRADVMLAGGAEAPLVCLQMKAWEAMRALAPDTCRPFSADRKGVVIGEGAGMAVLESYEHAAARGATMLAEIAGIGLSGDAFHIVAPSIEGPEAAMRACLADAGLNAEDVDYLNAHGTGTKANDQTETAAIKRVFGDYAYSMSVSSTKSMHAHCLGAASALEMIASVMAIQEGVVPPTANYREPDPDCDLDVTPNGARERKVRVALSNAFAMGGMNAVLAFKQV
>NZ_CP048406.1|WP_095780357.1|6256428_6257166_-|3-oxoacyl-[acyl-carrier-protein]-reductase
MFDLTGRKTLVTGASGGIGEAIARVLHAQGAVVGLHGTRVEKLETLAAELGDRVKLFPANLSNREEVKALGQKVEADLEGVDILVNNAGITKDGLFVRMSDADWDSVLEVNLTAVFRLTRELTHPMMRRRHGRIINITSVVGVTGNPGQTNYCASKAGMVGFSKSLAQEIATRNITVNCVAPGFIESAMTDKLNDKQKEAIMAAIPTRRMGTSAEVASAVAYLASNEAAYVTGQTIHVNGGMAMI
>NZ_CP048406.1|WP_065010676.1|6255360_6255951_-|NodA-family-N-acyltransferase
MCSDVRWRLCWENELQQADHVELSEFFRKTYGPTGAFNSEPFEDGRSWAGARPELRAISYDAHGVAAHIGILRRFIKVDEVELLVADLGLYGVRPDLEGQGISHSMRVVYPVLQQLGVPFAFGTVRHAMRNHMERFCRDGLAAIVSGVRVRSTLADVYLDLPPTRVEDVLVVVVPIGRSMSEWPSGTLIVRNGPEL
>NZ_CP048406.1|WP_065010674.1|6253301_6254291_-|nodulation-protein-NodZ
MLVDGSRMDRFVVSRRRTGFGDCLWSLASAWDYAHRTGRALAIDWRGSCYLDNPFANAFPAFFKPIEEIGGVRVICDDEINHVSFPGPFFPSWWNKPSIDCVYRPDEQIFQERDELNDLFQAQDDCEANTVVCDACLMWRCDEQAERTIFRSIRPRVEIEDRIEALYQEHFDGHSIIGVHVRHGNGEGIMDHAPYWADPKVALEQVCTAIRMAKAQPHPRPVRVFLCTDSAQVVDHLSGVFPELFTVPKRFQADQAGPLHSAALGTDGGFSALVEMYLLGRCDTVIRFPPTSAFTRYARLFVPRIVEFDLNDPRRLILIDNSFERSPAP
>NZ_CP048406.1|WP_065010673.1|6252058_6253159_-|GDP-mannose-4,6-dehydratase
MSKRKVALITGVTGQDGSYLAELLLEKGYSVHGIKRRSSLFNTGRIDHLYHDPHETGVDLTLHHGDLTDSSSLTRVIQLVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRILGLVEHTRYYQASTSELYGLVRETPQTETTPFYPRSPYAVAKLYAHWITVNYREAYNLYACNGILFNHESPARGETFVTRKITRALARVKLGMQRTLFLGNLNARRDWGHARDYVQMQWLMLQQEQPEDFVIASGEQHSVREFVTVAAAELGIDVRWVGEGVDEEGYDAKTGALIVKVDPRYFRPAEVETLLGDARKAKEKLGWAPKISFIELVREMVREDLRMAERDAVLMKQGYYSHSPRELC
>NZ_CP048406.1|WP_065010672.1|6251017_6251986_-|GDP-L-fucose-synthase
MENKKMKKVYVAGHRGLVGSATMRALEALGSYEIITRTHDQLDLFDRSETRRFFMSRRPDYVVMCAAKVGGILANASSPVDFLHNNLAIQVSVFDAAHASGVERMIFLGSSCIYPRDCPQPIREEYLLTGPLEATNRPYALAKIAGVESCWSFNRQYKARYLALMPTSLYGPGDNYHPENCHVLPALIRRFHQAKMNGDSSVEVWGSGNPRREFMYSSDVGDAIAFLLGLPDSDFDALTAPDTAPLINVGVGEDVTIREVAELVKAAVCWKGDLVFDTTKPDGTPRKLLDVTRLRNLGWKAKTSLGAGLQATYEDFLRLHGA
>NZ_CP048406.1|WP_141246637.1|6250247_6250478_-|hypothetical-protein
MVRAFTTLLQRVSLMAKRLALNQSLASAARQAVAQRDHPDALGWQWQVTAYAVSLAWLDWHYHTFYEKCCSLVRVT
>NZ_CP048406.1|WP_065010670.1|6249725_6250181_-|GNAT-family-N-acetyltransferase
MPFISTRRANATDAETVGRFSHALLDELSGGKAPTPDVVRQSAETVLADAGVVAVIASADDEPVGIMVLNECTAIYAGGKFGYISELYVRTDKRSKGIAPHLLEVASQESRARGWKRLEVGAPGQPKWKRTLDFYLRNGFEEVGPRLCRII
>NZ_CP048406.1|WP_082982604.1|6247555_6248866_-|acyltransferase
MSRAFQLTFTSVDFVGRPRRNRRIIRGRVSMNGMAAGQAGSGRFIALEGLRGLAAVGVLLSHALFAVEPGIFKTMYPLAQAAWPEIGWPAQLLTLPPFSMLINGSFAVCVFFVLSGFVLTKSFADTGNASVLVSRAIRRIPRLGIPIAASIVFAGTIFAMGLMRNLEVAPLTGSVWLTWYYPSSITAATIAQEALYESLFLGKNKLNSPLWTMSIELVGSYLAFMFAFAARWFTFALVTVFAAALSFAVHIAYLPFALSFGVGVLLTRVSAAKWPHEAKIVIFLAAIYLGGFSNAIWYEPIIKLSPIDFNPLKDAMHCVGAAFLVASVLALPSLQRAFSSYFFPLLGRLSFSVYLLHFPVLCSLGCFVYLWTIQWGHAIAASSTVVIVLVTTIIAAVPFQRLVDVKSMEVAKRVDQYLRGFCVRLRRRRLALRSTI
>NZ_CP048406.1|WP_065010997.1|6261930_6263163_+|cytochrome-P450
MRVENDHCDVIGVSVAPTQLNSLSAAILRQRGMARVSLPGNVVTWAAGRHQTLRRMFSDQRFNRDWRQWRALQDGEIPEDHPLIGMCKVDNMVTAHGADHRRLRGLLSRSFAPSRIASLAPRIEQCVDRLLAEMAQRGGSADLMCEFAVPLPTNVIAELFGLPDEQREEIVALTYSRANTSATAAEVRQTQQRIPEFFRRLIALKRGQLGDDLASALIVARDNGELVSDSELIDMLFMVLSAGFVTTTGVIGNGVLALLTHPQQLHLVRSGQVPWSQAIEEILRWGNAVANLPFRYATQDVEIDGSMVRRGDAVLMAFHAANRDEKAFGPGADRFDVTRRHNPHLSFGEGPHSCLGAELARLELRCAFPALFGRLEDLALTIAAEDVVYMPSYVIRCPQRLPVTFRPSIA
>NZ_CP048406.1|WP_065010996.1|6263179_6264382_+|cytochrome-P450
MSEQSLPTLPMWRVDHIEPSPEMLALCANGPIHRVRFPSGHEGWWVTGYDEAKAVLSDAAFRPAGMPPAAFTPDSVILGSPGWLVSHEGGEHARLRTIVAPAFSNRRVKLLAQQVEAIAAQLFETLAAQPQPADLRRHLSFPLPAMVISALMGVLYEDHAFFAGLSDEVMTHQHESGPRTASRLAWEELRTYIRGKMRDKRQDPGDNLLTDLLAAVDQGKATEEEAIGLAAGILVAGHESTVAQIEFGLLAMFRHPQQRERLVGEPFLVDKAVEEILRMYPPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPRHFDDPEIFDIGRDENPHLAFSYGPHNCTGAALARLELKVVFGSIFQRFPALRLAVSPEELKLRKEIITGGFEELPVLW
>NZ_CP048406.1|WP_065010995.1|6264476_6265766_+|cytochrome-P450
MDVQETTAACRDAFAELASPACIHDPYPFMRWLREHDPVHRAASGLFLLSRHVDIYWALKATGDAFRGPAPGELARYFPRAATSLSLNLLASTLAMMDPPTHTRLRRLISRDFTMRQIDDLRPSIARIATARLDGMAPALERGEAVDLHREFALALPMLVFAELFGMPQDDMFGLAAGIGPILEGLSPHASDPQLAAADAASAKVQAYFGDLIQRKRTDPHHNIVSMLVGAHDDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAHPEQRHWLQGDAVGVKAFVEEVLRCDAPAMFSSIPRIAQRDIELGGVVIPKNADVRVLIAAGNRDPDAFADPDRFDPVRFYGTSPGMSSDGKIMLSFGHGIHFCLGAQLARVQLAESLPRIQARFPTLALAEQPTREPSAFLRTFRALPVRLHAQGG
>NZ_CP048406.1|WP_065010994.1|6265767_6266076_+|ferredoxin
MRVVVDQDLCGTTGQCVLTLPGTFRQREPDGVAEVCVVTVPQALHAAVRLAAGQCPVAAIRVIESDSGDGERASANPAPSPAEAYRHAAKDQRNPGGHDGTV
>NZ_CP048406.1|WP_065010993.1|6266062_6266908_+|SDR-family-oxidoreductase
MGRFEGKVAVVTGAGAGIGKACALALAREGGRVVVADIDGSAAIACTAQIAAEAGHALALAMDIADAQAVAALFETAERHFGGVDLLVNNASAMHLTPRDHAILDLDLAVWDQIMATNLRGTLLCCRQAIPRMIARGGGAIVNMSSCQGLSGDTAQTSYAASKAAMNMLSASLATQYGHAQIRCNAVAPGLIMTERLLAKLDECMQRHLRRHQLLPRVGRPEDVAALVAFLLSDDAAFITGQVVCIDGGMLAHVPTYADGGNSRAARPAGDIAEAAAAPRC
>NZ_CP048406.1|WP_065010992.1|6266907_6268251_+|cytochrome-P450
MDMLLNPLDRRHRLRHKIPIVPGAFPLVGHLPAIVCDLPRLLRRAERTLGSHFWLDFGPAGHLMTCTHPDAFALLRHKDVSSALMEEIAPELLGGTLVAQDGGAHRQARDAIKAAFLPKGLTQAGIGDLFAPIILARVQAWRERGDVTILRETGDLTLKLIFSLMGIPANDLPGWHRKYRQLLQLIIAPPIDLPGLPLRRGRAARDWIDAQLRQFIRDARAHAARTGLINDMVSAFDRSDDALSDDVLVANIRLLLLGGHDTTASTMAWMVIELARQPVLWDALVEEAQRVGAVPTRHADLAQCPVAEALFRETLRVHPATTVLPRRALQELQLGQRRIPAGTHLCIPLLHFSTSALLHEAPDQFRLERWLQRTQPIRPVDMLQFGTGPHVCIGYHLVWLELVQFSIALALTMHKAGVRPRLLSGVEKGRRYYPTAHPSMTIRIGFS
>NZ_CP048406.1|WP_065011000.1|6268399_6269398_+|farnesyl-diphosphate-synthase
MQTGSTLHDDRTGVSALGGLGAQARGASGRLLPEIWMQDGAKRVEQALARLLCAEDDGETELMTAMRYATLHGGKRTRALLCLAAGALADTPAHMLDDVGAAIEMMHACTLVHDDLPAMDDDVLRRGLPTVHVKFGEATAILVGDALQAHAFLTLASLDAPDHNRIALVRELAQAVSAEGAAGGQAMDLSLVGKQVELDRIVAMHRMKSGALVRASVRMGALCAIAEDAAHAALYCALDRYSACFGLALQVVDDILDATADTATLGKIPGKDAAAQKPTCASIMGLQAARQFALDLLRDAGQAIAPLGPRAERLAQMLQRANAYLLKHAPCA
>NZ_CP048406.1|WP_065010990.1|6269681_6271232_+|hypothetical-protein
MNALSEQILSELRHLLSEMSDGGSVGPSVYDTARALQFHGNVTGRQDAYAWLLAQQQADGGWGSADFPLFRHAPTWAALLALQRADPLPGAADAVQAATRFLERQPDPYAHAVPEDAPIGAELILPQLCGEAASLLGGVAFPRHPALLPLRQACLVRLGAVATLPSGHPLLHSWEAWGTSPTTACPDDDGSIGISPAATATWRAHAVTQGSTPQVERADAYLQAASRATRSGIEGVVPNVWPINVFEPCWSLYTLHLAGLFAHPALAEAVRVIVAQLDARLGVRGLGPALHFAADADDTAVALCVLRLAGRDPAVDALRHFEIGELFVTFPGERNASVSTNIHALHALRLLGKPAADTSAYVEANRNPHGLWDNEKWHVSWLYPTAHAVAALAQGNPRWRDERALAALLQAQRDGGGWGAGRASTFEETAYALFALHVMDGSEEPTGRRRIAQAVARALEWMLARHAAHALPQTPLWIGKELYCPTRVVRVAELAGLLLALRWGRRVLAEGPGAAP
>NZ_CP048406.1|WP_065010989.1|6272214_6273261_+|type-2-isopentenyl-diphosphate-Delta-isomerase
MSDTALSRRKDDHLDIVLDRRTAPATVAGWEYIRFEHCALPELDLTQIDLRASLLGKTMRAPLLISSMTGGMPRAEAVNRHLSEAAQALGIAMCVGSQRVSLQSRNFQGLTRALRRLAPDIPLLANIGAAQLREADGLDLARRAVDALEADGLIVHLNPLQEAVQPEGDRDWRGVLAQIARAARSVGVPIVAKEVGAGLSALVACALVEAGVAVIDVAGAGGTSWAAVEGERARDAADRAVAMAFADWGIPTPASVQAVRRALPTVKLIASGGIRDGVDVAKAIHLGADIAGQAAGVLRAATVSTEAVVAHFEIVIRQLAVACFCTGSADLAALRQARLLPSAHLPAG
>NZ_CP048406.1|WP_082982652.1|6273537_6274569_+|hypothetical-protein
MLNRGMVLERIPAARLEALAQAAEAYVQHAFGRRLELTPIAPTNVPHFVLDRYMLWEGLLDGRTLVVMAICEPRQGATTDYLKHRDLVRRQLGVDLILLLLDHVPNAVRRQMVERQIGFIAPGAQLYVPEALLDLRERARTTAIAPADQISPTTQLVLLAVLQGIALEEEHLTDLAERLHVSIMSISRTLDELEALQLAKARHVGRQRRLHMLLGGHELWEAIQERLQSPVRKVRLVSGRVENQIAPLAGESALARYTMLAAPRVQTRAILSMRWKRLKERLALSPATAFDDDRLEIQTWTYDPQILARDAVIDRLSLYLSVRGSTDERVAQAAEELLERFEW

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP048406_11	11.1\|6259142\|26\|NZ_CP048406\|CRISPRCasFinder	6259142-6259167	26	NZ_CP048406.1	6259078-6259103	0	1.0

1. spacer 11.1|6259142|26|NZ_CP048406|CRISPRCasFinder matches to position: 6259078-6259103, mismatch: 0, identity: 1.0

cggattaaagagacctgatgagttcc	CRISPR spacer
cggattaaagagacctgatgagttcc	Protospacer
**************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP048406_1	1.1\|38040\|29\|NZ_CP048406\|CRISPRCasFinder	38040-38068	29	NZ_CP009123	Sphingopyxis fribergensis strain Kp5.2 plasmid pSfKp5.2, complete sequence	25435-25463	4	0.862
NZ_CP048406_7	7.1\|6190332\|29\|NZ_CP048406\|CRT	6190332-6190360	29	NC_014502	Gloeothece verrucosa PCC 7822 plasmid Cy782203, complete sequence	36669-36697	7	0.759
NZ_CP048406_7	7.1\|6190332\|29\|NZ_CP048406\|CRT	6190332-6190360	29	NZ_CP050098	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b4, complete sequence	574114-574142	7	0.759
NZ_CP048406_7	7.1\|6190332\|29\|NZ_CP048406\|CRT	6190332-6190360	29	NZ_CP053440	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eF, complete sequence	645478-645506	7	0.759
NZ_CP048406_7	7.1\|6190332\|29\|NZ_CP048406\|CRT	6190332-6190360	29	NC_012853	Rhizobium leguminosarum bv. trifolii WSM1325 plasmid pR132503, complete sequence	282120-282148	7	0.759
NZ_CP048406_7	7.1\|6190332\|29\|NZ_CP048406\|CRT	6190332-6190360	29	NC_012811	Methylorubrum extorquens AM1 megaplasmid, complete sequence	664128-664156	8	0.724
NZ_CP048406_7	7.1\|6190332\|29\|NZ_CP048406\|CRT	6190332-6190360	29	NZ_CP011519	Pandoraea oxalativorans strain DSM 23570 plasmid pPO70-2, complete sequence	34262-34290	8	0.724
NZ_CP048406_10	10.6\|6193069\|47\|NZ_CP048406\|CRT	6193069-6193115	47	FJ375326	Mesorhizobium phage AM-2008 genomic sequence	7025-7071	13	0.723

1. spacer 1.1|38040|29|NZ_CP048406|CRISPRCasFinder matches to NZ_CP009123 (Sphingopyxis fribergensis strain Kp5.2 plasmid pSfKp5.2, complete sequence) position: , mismatch: 4, identity: 0.862

cttttggggtgatgctcggtttctttgcc	CRISPR spacer
ctgcaggggtgatgctcggtttcttcgcc	Protospacer
** . ********************.***

2. spacer 7.1|6190332|29|NZ_CP048406|CRT matches to NC_014502 (Gloeothece verrucosa PCC 7822 plasmid Cy782203, complete sequence) position: , mismatch: 7, identity: 0.759

atgttcgcttccaagaaggctgtcgcccc	CRISPR spacer
gtgttcgcctccaagaaggctatcgaaaa	Protospacer
.*******.************.***

3. spacer 7.1|6190332|29|NZ_CP048406|CRT matches to NZ_CP050098 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b4, complete sequence) position: , mismatch: 7, identity: 0.759

atgttcgcttccaagaaggctgtcgcccc	CRISPR spacer
cctgtcgcttccaacaaggctatcgccgc	Protospacer
 .  ********** ******.***** *

4. spacer 7.1|6190332|29|NZ_CP048406|CRT matches to NZ_CP053440 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eF, complete sequence) position: , mismatch: 7, identity: 0.759

atgttcgcttccaagaaggctgtcgcccc	CRISPR spacer
cctgtcgcttccaacaaggctatcgccgc	Protospacer
 .  ********** ******.***** *

5. spacer 7.1|6190332|29|NZ_CP048406|CRT matches to NC_012853 (Rhizobium leguminosarum bv. trifolii WSM1325 plasmid pR132503, complete sequence) position: , mismatch: 7, identity: 0.759

atgttcgcttccaagaaggctgtcgcccc	CRISPR spacer
cccgtcgcttccaacaaggctatcgccgc	Protospacer
 .  ********** ******.***** *

6. spacer 7.1|6190332|29|NZ_CP048406|CRT matches to NC_012811 (Methylorubrum extorquens AM1 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.724

atgttcgcttccaagaaggctgtcgcccc	CRISPR spacer
cccgctgctcccaagaaggctgacgcccc	Protospacer
 .  ..***.************ ******

7. spacer 7.1|6190332|29|NZ_CP048406|CRT matches to NZ_CP011519 (Pandoraea oxalativorans strain DSM 23570 plasmid pPO70-2, complete sequence) position: , mismatch: 8, identity: 0.724

atgttcgcttccaagaaggctgtcgcccc	CRISPR spacer
tctgcggcttccaagaaggctttcgccac	Protospacer
 .  . *************** ***** *

8. spacer 10.6|6193069|47|NZ_CP048406|CRT matches to FJ375326 (Mesorhizobium phage AM-2008 genomic sequence) position: , mismatch: 13, identity: 0.723

tcgttctaaaccggaacggtaccaattgagatcgtcgcccctcacac	CRISPR spacer
tcgttctaaaccggaacggtaccgattgagatcagtagtcaccgtct	Protospacer
***********************.*********. .. .* .*.. .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3285276 : 3293178

Brucella_phage(25.0%)

capsid,head,terminase,portal,tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163603038.1\|3285276_3286875_-\|terminase	terminase large subunit	A0A141GEV8	Brucella_phage	1.3e-39	27.4
WP_065012231.1\|3286837_3287245_-\|terminase	phage terminase small subunit P27 family	NA	NA	NA	NA
WP_065012230.1\|3287244_3287559_-\|head	phage head closure protein	NA	NA	NA	NA
WP_065012229.1\|3287555_3287972_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_065012228.1\|3287968_3288220_-	hypothetical protein	NA	NA	NA	NA
WP_065012227.1\|3288216_3288582_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_065012226.1\|3288581_3288884_-\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_065012225.1\|3289010_3289199_+	hypothetical protein	NA	NA	NA	NA
WP_065012224.1\|3289610_3289994_-	hypothetical protein	A0A142K633	Streptomyces_phage	5.8e-15	46.0
WP_065012223.1\|3290048_3291629_-\|capsid	phage major capsid protein	B0VK33	Azospirillum_phage	1.7e-52	40.7
WP_065012222.1\|3291625_3291988_-	gene transfer agent family protein	NA	NA	NA	NA
WP_065012221.1\|3291984_3293178_-\|portal	phage portal protein	A0A2K5B287	Erysipelothrix_phage	4.0e-38	30.7

DBSCAN-SWA_2

3450728 : 3459317

uncultured_Mediterranean_phage(85.71%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_163603041.1\|3450728_3451571_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	2.5e-34	34.3
WP_029353166.1\|3451567_3452347_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	3.4e-38	43.9
WP_029353164.1\|3452527_3452749_+	twin-arginine translocase TatA/TatE family subunit	A0A1B1IVR9	uncultured_Mediterranean_phage	5.1e-08	65.9
WP_065007765.1\|3452777_3453455_+	twin-arginine translocase subunit TatB	NA	NA	NA	NA
WP_051695763.1\|3453499_3454309_+	twin-arginine translocase subunit TatC	A0A1B1IVR7	uncultured_Mediterranean_phage	1.3e-51	49.2
WP_065007767.1\|3454650_3456186_+\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	4.6e-95	47.0
WP_065007768.1\|3456185_3456944_+	5'/3'-nucleotidase SurE	NA	NA	NA	NA
WP_065007809.1\|3456946_3457606_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	3.9e-19	40.4
WP_065007769.1\|3457820_3459317_+	peptidoglycan DD-metalloendopeptidase family protein	S6B1Q4	Bacillus_phage	3.1e-11	37.5

DBSCAN-SWA_3

6029771 : 6080301

Acidithiobacillus_phage(22.22%)

transposase,integrase

attL 6023342:6023359|attR 6047703:6047720

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
6023342:6023359	attL	NA	NA	NA	NA
WP_095780361.1\|6029771_6030290_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A1B0Z042	Pseudomonas_phage	1.7e-30	41.3
WP_065009155.1\|6030386_6032165_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_082982466.1\|6032186_6033185_-	ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	1.0e-26	35.6
WP_065009186.1\|6033428_6034529_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_065009153.1\|6035015_6035669_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_065009151.1\|6036455_6037010_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_065009150.1\|6037777_6038953_-	aminopeptidase P family protein	NA	NA	NA	NA
WP_065009149.1\|6039711_6041007_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_141246641.1\|6041743_6042019_-	hypothetical protein	NA	NA	NA	NA
WP_065009147.1\|6042241_6042748_-	hypothetical protein	NA	NA	NA	NA
WP_065009146.1\|6042740_6045806_-	sarcosine oxidase subunit alpha family protein	NA	NA	NA	NA
WP_065009145.1\|6045802_6046069_-	sarcosine oxidase subunit delta	NA	NA	NA	NA
WP_065009144.1\|6046087_6047344_-	sarcosine oxidase subunit beta family protein	NA	NA	NA	NA
WP_065009143.1\|6048225_6049656_-	dipeptidase	NA	NA	NA	NA
6047703:6047720	attR	NA	NA	NA	NA
WP_065009141.1\|6050222_6051011_-	hypothetical protein	NA	NA	NA	NA
WP_065012429.1\|6051148_6052330_-	M24 family metallopeptidase	NA	NA	NA	NA
WP_065012430.1\|6052430_6053171_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.6e-29	36.6
WP_065012428.1\|6053290_6054265_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_065012427.1\|6054328_6055171_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_065012426.1\|6055717_6056737_-	aryldialkylphosphatase	NA	NA	NA	NA
WP_082982812.1\|6056969_6057383_-	hypothetical protein	NA	NA	NA	NA
WP_082982811.1\|6057858_6059268_-	aspartate aminotransferase family protein	A0A1V0SKB7	Klosneuvirus	5.2e-21	24.8
WP_065012424.1\|6061182_6062013_+	3-keto-5-aminohexanoate cleavage protein	NA	NA	NA	NA
WP_065012423.1\|6062128_6063091_+	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_065012422.1\|6063422_6063644_-	hypothetical protein	NA	NA	NA	NA
WP_141246659.1\|6063864_6065376_+\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	7.9e-116	44.5
WP_065008691.1\|6065388_6066144_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	1.2e-56	46.9
WP_065007546.1\|6066278_6066869_-	hypothetical protein	NA	NA	NA	NA
WP_065007547.1\|6066865_6069055_-	acetyl-CoA synthetase	NA	NA	NA	NA
WP_065007549.1\|6069057_6069840_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_163603086.1\|6069985_6070168_+	hypothetical protein	NA	NA	NA	NA
WP_163603087.1\|6070570_6071770_-	M24 family metallopeptidase	NA	NA	NA	NA
WP_141246658.1\|6071989_6072268_+	hypothetical protein	NA	NA	NA	NA
WP_065007544.1\|6073939_6074488_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_163603088.1\|6075285_6076485_+\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	1.1e-80	42.4
WP_065007842.1\|6076663_6077692_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_065008564.1\|6078169_6079042_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	8.8e-51	46.7
WP_065008565.1\|6079038_6080301_-\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	5.2e-44	36.3

DBSCAN-SWA_4

6380996 : 6438798

Caulobacter_phage(25.0%)

protease,holin,transposase,integrase

attL 6431878:6431901|attR 6434512:6434535

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065008855.1\|6380996_6381701_-\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_065008856.1\|6381714_6381954_-	hypothetical protein	NA	NA	NA	NA
WP_065008858.1\|6383812_6384091_+	WGR domain-containing protein	NA	NA	NA	NA
WP_065008859.1\|6384105_6384375_-	DUF4326 domain-containing protein	A0A1L2C8W5	Pseudomonas_phage	8.1e-24	56.3
WP_065008860.1\|6384438_6384837_-	single-stranded DNA-binding protein	A0A193GYD7	Enterobacter_phage	1.5e-10	34.3
WP_065008861.1\|6385766_6386699_-	DUF1738 domain-containing protein	A0A1V0EEV1	Caulobacter_phage	1.0e-68	46.9
WP_065008862.1\|6386978_6387164_-	hypothetical protein	NA	NA	NA	NA
WP_065008863.1\|6387356_6388514_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_023801727.1\|6388972_6389275_+	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_065008864.1\|6389271_6389733_+	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_065008865.1\|6390874_6391210_-	hypothetical protein	NA	NA	NA	NA
WP_095780349.1\|6391206_6392088_-	hypothetical protein	NA	NA	NA	NA
WP_156768364.1\|6392233_6392551_+	hypothetical protein	NA	NA	NA	NA
WP_065008868.1\|6392654_6394337_-	ParB N-terminal domain-containing protein	NA	NA	NA	NA
WP_065008869.1\|6399777_6400176_-	DUF3085 domain-containing protein	NA	NA	NA	NA
WP_065008870.1\|6400186_6400789_-	DUF1419 domain-containing protein	NA	NA	NA	NA
WP_065008903.1\|6400929_6401883_-	DUF3991 domain-containing protein	NA	NA	NA	NA
WP_065008871.1\|6402850_6403441_+	SOS response-associated peptidase	NA	NA	NA	NA
WP_065008872.1\|6403469_6404462_-	hypothetical protein	A0A291AUP8	Sinorhizobium_phage	7.6e-51	36.2
WP_065008873.1\|6406005_6406539_-	MucR family transcriptional regulator	A0A1P8VVG0	Erythrobacter_phage	3.7e-20	47.2
WP_082982435.1\|6406875_6407031_+	KTSC domain-containing protein	NA	NA	NA	NA
WP_095780346.1\|6407475_6407913_-	response regulator	NA	NA	NA	NA
WP_141246633.1\|6408045_6408471_-	hypothetical protein	NA	NA	NA	NA
WP_065008904.1\|6409065_6409275_-	hypothetical protein	NA	NA	NA	NA
WP_065008905.1\|6409394_6409601_-	KTSC domain-containing protein	NA	NA	NA	NA
WP_065008877.1\|6409923_6410112_+	hypothetical protein	F1ADP1	Caulobacter_phage	4.5e-05	45.3
WP_082982436.1\|6410533_6411313_+	hypothetical protein	NA	NA	NA	NA
WP_095780347.1\|6411392_6413189_+	methanol/ethanol family PQQ-dependent dehydrogenase	NA	NA	NA	NA
WP_082982437.1\|6413169_6414033_+	quinoprotein dehydrogenase-associated putative ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_065008880.1\|6414034_6414568_+	c-type cytochrome	NA	NA	NA	NA
WP_065008881.1\|6414585_6415578_+	cytochrome c oxidase subunit II	NA	NA	NA	NA
WP_082982438.1\|6415574_6417533_+	cytochrome c oxidase subunit I	R9VX24	Flavobacterium_phage	8.1e-12	40.0
WP_065008882.1\|6417529_6418135_+	cytochrome C oxidase subunit III	NA	NA	NA	NA
WP_065008883.1\|6418136_6418478_+	hypothetical protein	NA	NA	NA	NA
WP_065008884.1\|6418474_6419353_+	cytochrome c oxidase assembly protein	NA	NA	NA	NA
WP_065008885.1\|6419333_6419744_+	c-type cytochrome	NA	NA	NA	NA
WP_065008886.1\|6420207_6420453_-	DUF982 domain-containing protein	NA	NA	NA	NA
WP_065008887.1\|6420461_6420707_-	DUF982 domain-containing protein	NA	NA	NA	NA
WP_082982439.1\|6420810_6421020_-	hypothetical protein	NA	NA	NA	NA
WP_065008888.1\|6421542_6421728_+	hypothetical protein	NA	NA	NA	NA
WP_065008889.1\|6421724_6421952_+	hypothetical protein	NA	NA	NA	NA
WP_163603098.1\|6422069_6422531_+	hypothetical protein	NA	NA	NA	NA
WP_065006357.1\|6424545_6425574_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_141246656.1\|6426592_6426970_+	hypothetical protein	NA	NA	NA	NA
WP_065006983.1\|6427041_6428532_+	radical SAM family RiPP maturation amino acid epimerase	NA	NA	NA	NA
WP_156768225.1\|6428528_6428687_+	hypothetical protein	NA	NA	NA	NA
WP_065006981.1\|6429334_6430576_+	glycosyltransferase	NA	NA	NA	NA
WP_065006980.1\|6431013_6431844_+	alpha/beta hydrolase	A0A249XU20	Mycobacterium_phage	2.2e-11	33.9
6431878:6431901	attL	NA	NA	NA	NA
WP_163603123.1\|6432064_6432667_+	plasmid pRiA4b ORF-3 family protein	NA	NA	NA	NA
WP_065008802.1\|6432647_6432896_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_095780379.1\|6433108_6434509_+\|transposase	ISKra4 family transposase	NA	NA	NA	NA
WP_065011708.1\|6436771_6437959_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
6434512:6434535	attR	NA	NA	NA	NA
WP_065011722.1\|6437973_6438798_+\|holin	phosphocholine cytidylyltransferase family protein	NA	NA	NA	NA

DBSCAN-SWA_5

6453809 : 6499215

Tetraselmis_virus(25.0%)

transposase,integrase

attL 6484799:6484815|attR 6510601:6510617

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_095780379.1\|6453809_6455210_-\|transposase	ISKra4 family transposase	NA	NA	NA	NA
WP_065008802.1\|6455422_6455671_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_095780378.1\|6455651_6456032_-	hypothetical protein	NA	NA	NA	NA
WP_082982275.1\|6456172_6457750_+\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_065007357.1\|6457836_6458541_-	nitroreductase	NA	NA	NA	NA
WP_141246650.1\|6459755_6460130_+\|transposase	transposase	NA	NA	NA	NA
WP_065011813.1\|6461482_6461701_+	hypothetical protein	A0A2P0VMP9	Tetraselmis_virus	8.9e-05	50.0
WP_065011814.1\|6461712_6462000_+	hypothetical protein	NA	NA	NA	NA
WP_065011815.1\|6462138_6462984_-	EamA family transporter	NA	NA	NA	NA
WP_065011819.1\|6464130_6464805_+	hypothetical protein	NA	NA	NA	NA
WP_082982734.1\|6468298_6471313_+	hypothetical protein	NA	NA	NA	NA
WP_065011822.1\|6471309_6472392_+	zinc ribbon domain-containing protein	NA	NA	NA	NA
WP_065011823.1\|6472458_6473022_+	hypothetical protein	NA	NA	NA	NA
WP_065011824.1\|6473763_6474537_+	hypothetical protein	NA	NA	NA	NA
WP_095780369.1\|6477250_6478345_+\|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_141246649.1\|6478417_6478723_+	hypothetical protein	NA	NA	NA	NA
WP_065009289.1\|6479139_6479790_+	response regulator transcription factor	NA	NA	NA	NA
WP_065006357.1\|6480199_6481228_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_082982149.1\|6481452_6482502_+	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_065006362.1\|6483767_6485159_+	insulinase family protein	A0A2P1EIE5	Megavirus	1.8e-21	22.8
6484799:6484815	attL	NA	NA	NA	NA
WP_065006359.1\|6485163_6486552_+	insulinase family protein	G3MBJ8	Bacillus_virus	8.8e-13	21.8
WP_065006361.1\|6487778_6489065_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_095780374.1\|6489111_6489714_+	plasmid pRiA4b ORF-3 family protein	NA	NA	NA	NA
WP_065007981.1\|6489969_6491370_+\|transposase	ISKra4 family transposase	NA	NA	NA	NA
WP_163603100.1\|6492284_6494624_-	prolyl oligopeptidase family serine peptidase	NA	NA	NA	NA
WP_065005808.1\|6494717_6495071_-	hypothetical protein	NA	NA	NA	NA
WP_065005810.1\|6496206_6496947_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	3.3e-14	26.7
WP_065006111.1\|6496950_6497964_-	DUF1403 family protein	NA	NA	NA	NA
WP_163602977.1\|6497893_6498052_+	hypothetical protein	NA	NA	NA	NA
WP_082982083.1\|6498090_6499215_+\|integrase	site-specific integrase	NA	NA	NA	NA
6510601:6510617	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP048406

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection