CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP013652	Paenibacillus naphthalenovorans strain 32O-Y chromosome, complete genome	3 crisprs	DEDDh,cas3,cas5,cas8c,cas7,cas4,cas1,cas2,csa3,cas14k,c2c9_V-U4,cas14j,DinG	0	4	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013652_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013652_1

696977-698005

TypeI

Consensus_repeat	Method
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	PILER-CR
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CRT

15 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP013652_1

>merge|NZ_CP013652|1|696977-698005|PILER-CR,CRISPRCasFinder,CRT
GTCGCATCCCATGCGGATGCGTGGATTGAAATTCTTTTCGGTAAACAGCAAAATCAACAATGGACTTGTCGCATCCCATGCGGATGCGTGGATTGAAATTCCACCCTTTTGAGCGCCTTTCTTGAATAAAACAGTCGCATCCCATGCGGATGCGTGGATTGAAATCGGCAGCAGCTGCATAACGAAAAGCTGAAGGTTTTGTCGCATCCCATGCGGATGCGTGGATTGAAATAGCGACGGGCTGCGCACCCTTAACGTCCAGGACAAGTCGCATCCCATGCGGATGCGTGGATTGAAATCGTCCAAGTGTTGTACGGGGAGTCGGCTGGCACGTCGCATCCCATGCGGATGCGTGGATTGAAATATATACATCGGCAGCGATACACAAAAAGAATCCAGTCGCATCCCATGCGGATGCGTGGATTGAAATCTAAAATAAAAAATGATTTGCGTAAAAAACTTGACGTCGCATCCCATGCGGATGCGTGGATTGAAATGACAAAGTTACAGGAACACCGTTTCAGCCTTAAGTCGCATCCCATGCGGATGCGTGGATTGAAATTTTTCCCCTCCTGCTAGTTTTAGCCCACATGCTCGAGTCGCATCCCATGCGGATGCGTGGATTGAAATTCCCCAGGACTTGGACATAATCAATCGGGAGTTAGGTCGCATCCCATGCGGATGCGTGGATTGAAATTACTAACAAAACAGTAGGCTATAATGGGTTTAAAAGTCGCATCCCATGCGGATGCGTGGATTGAAATTACCGTGGCAGGAAATTACCTCTATCCCATACCGGGTCGCATCCCATGCGGATGCGTGGATTGAAATATCATGTACTTTGTCAGATAGGCACCCACGTTGTCGTCGCATCCCATGCGGATGCGTGGATTGAAATCAGGCGTAGAAGTCAACATGAAGGAAGGTCTGAGTCGCATCCCATGCGGATGCGTGGATTGAAATTAGACCGGCGGCCAACTCGCAGTTTACGCCGTCAGTCGCATCCCATGCGGATGCGTGAATTGAAAT

>NZ_CP013652|1|1|696977-698005|PILER-CR
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TCTTTTCGGTAAACAGCAAAATCAACAATGGACTT
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TCCACCCTTTTGAGCGCCTTTCTTGAATAAAACA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CGGCAGCAGCTGCATAACGAAAAGCTGAAGGTTTT
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	AGCGACGGGCTGCGCACCCTTAACGTCCAGGACAA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CGTCCAAGTGTTGTACGGGGAGTCGGCTGGCAC
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	ATATACATCGGCAGCGATACACAAAAAGAATCCA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CTAAAATAAAAAATGATTTGCGTAAAAAACTTGAC
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	GACAAAGTTACAGGAACACCGTTTCAGCCTTAA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TTTTCCCCTCCTGCTAGTTTTAGCCCACATGCTCGA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TCCCCAGGACTTGGACATAATCAATCGGGAGTTAG
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TACTAACAAAACAGTAGGCTATAATGGGTTTAAAA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TACCGTGGCAGGAAATTACCTCTATCCCATACCGG
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	ATCATGTACTTTGTCAGATAGGCACCCACGTTGTC
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CAGGCGTAGAAGTCAACATGAAGGAAGGTCTGA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TAGACCGGCGGCCAACTCGCAGTTTACGCCGTCA
GTCGCATCCCATGCGGATGCGTGAATTGAAAT

>NZ_CP013652|1|1|696977-698005|CRISPRCasFinder
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TCTTTTCGGTAAACAGCAAAATCAACAATGGACTT
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TCCACCCTTTTGAGCGCCTTTCTTGAATAAAACA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CGGCAGCAGCTGCATAACGAAAAGCTGAAGGTTTT
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	AGCGACGGGCTGCGCACCCTTAACGTCCAGGACAA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CGTCCAAGTGTTGTACGGGGAGTCGGCTGGCAC
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	ATATACATCGGCAGCGATACACAAAAAGAATCCA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CTAAAATAAAAAATGATTTGCGTAAAAAACTTGAC
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	GACAAAGTTACAGGAACACCGTTTCAGCCTTAA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TTTTCCCCTCCTGCTAGTTTTAGCCCACATGCTCGA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TCCCCAGGACTTGGACATAATCAATCGGGAGTTAG
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TACTAACAAAACAGTAGGCTATAATGGGTTTAAAA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TACCGTGGCAGGAAATTACCTCTATCCCATACCGG
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	ATCATGTACTTTGTCAGATAGGCACCCACGTTGTC
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CAGGCGTAGAAGTCAACATGAAGGAAGGTCTGA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TAGACCGGCGGCCAACTCGCAGTTTACGCCGTCA
GTCGCATCCCATGCGGATGCGTGAATTGAAAT

>NZ_CP013652|1|1|696977-698005|CRT
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TCTTTTCGGTAAACAGCAAAATCAACAATGGACTT
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TCCACCCTTTTGAGCGCCTTTCTTGAATAAAACA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CGGCAGCAGCTGCATAACGAAAAGCTGAAGGTTTT
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	AGCGACGGGCTGCGCACCCTTAACGTCCAGGACAA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CGTCCAAGTGTTGTACGGGGAGTCGGCTGGCAC
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	ATATACATCGGCAGCGATACACAAAAAGAATCCA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CTAAAATAAAAAATGATTTGCGTAAAAAACTTGAC
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	GACAAAGTTACAGGAACACCGTTTCAGCCTTAA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TTTTCCCCTCCTGCTAGTTTTAGCCCACATGCTCGA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TCCCCAGGACTTGGACATAATCAATCGGGAGTTAG
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TACTAACAAAACAGTAGGCTATAATGGGTTTAAAA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TACCGTGGCAGGAAATTACCTCTATCCCATACCGG
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	ATCATGTACTTTGTCAGATAGGCACCCACGTTGTC
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	CAGGCGTAGAAGTCAACATGAAGGAAGGTCTGA
GTCGCATCCCATGCGGATGCGTGGATTGAAAT	TAGACCGGCGGCCAACTCGCAGTTTACGCCGTCA
GTCGCATCCCATGCGGATGCGTGAATTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013652.1\|WP_054818007.1\|703199_703400_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013652.1\|WP_062407241.1\|700629_701328_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP013652.1\|WP_054820100.1\|696516_696807_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP013652.1\|WP_062407243.1\|701377_702673_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	unknown	unknown	gnl\|CDD\|176890
NZ_CP013652.1\|WP_062407258.1\|706576_706771_+\|YqzE-family-protein	unknown	unknown	gnl\|CDD\|372887
NZ_CP013652.1\|WP_062407224.1\|685126_686179_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP013652.1\|WP_062407240.1\|698781_699744_+\|2,3-dihydroxybiphenyl-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|274480
NZ_CP013652.1\|WP_062407228.1\|688661_691088_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP013652.1\|WP_062407230.1\|691990_693883_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	pfam09709_cas8c_CAS-I-C	gnl\|CDD\|187887
NZ_CP013652.1\|WP_062407232.1\|693898_694759_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|187820
NZ_CP013652.1\|WP_062407254.1\|704055_704496_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|223149
NZ_CP013652.1\|WP_062407236.1\|695404_696436_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NZ_CP013652.1\|WP_054820098.1\|691274_691994_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|273847
NZ_CP013652.1\|WP_062407234.1\|694748_695408_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP013652.1\|WP_062407253.1\|703513_703999_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP013652.1\|WP_062407251.1\|702665_703169_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-beta	unknown	unknown	gnl\|CDD\|238357
NZ_CP013652.1\|WP_062407256.1\|704786_706502_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|183534
NZ_CP013652.1\|WP_062407226.1\|686736_688263_+\|tripartite-tricarboxylate-transporter-permease	unknown	unknown	gnl\|CDD\|225870
NZ_CP013652.1\|WP_074727948.1\|699803_700640_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|132386
NZ_CP013652.1\|WP_054820097.1\|686262_686724_+\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815

Protein	Function_ID	Function_description	E-value
NZ_CP013652.1\|WP_062407241.1\|700629_701328_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.28677e-36
NZ_CP013652.1\|WP_054820100.1\|696516_696807_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	6.92761e-31
NZ_CP013652.1\|WP_062407243.1\|701377_702673_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	gnl\|CDD\|176890	cd08881, RHO_alpha_C_NDO-like, C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases. C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs, also known as aromatic ring hydroxylating dioxygenases). This domain binds non-heme Fe(II). RHOs utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents form the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. Proteins belonging to this subgroup include the terminal oxygenase alpha subunits of biphenyl dioxygenase, cumene dioxygenase from Pseudomonas fluorescens IP01, ethylbenzene dioxygenase, naphthalene 1,2-dioxygenase, nitrobenzene dioxygenase from Comamonas sp. strain JS765, toluene 2,3-dioxygenase from Pseudomonas putida F1, dioxin dioxygenase of Sphingomonas sp. Strain RW1, and the polycyclic aromatic hydrocarbons (PAHs)degrading ring-hydroxylating dioxygenase from Sphingomonas CHY-1. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.	2.01536e-75
NZ_CP013652.1\|WP_062407258.1\|706576_706771_+\|YqzE-family-protein	gnl\|CDD\|372887	pfam14038, YqzE, YqzE-like protein. The YqzE-like protein family includes the B. subtilis YqzE protein, which is functionally uncharacterized. It is a part of the ComG operon, which is regulated by the competence transcription factor ComK. This family of proteins is found in bacteria. Proteins in this family are typically between 49 and 66 amino acids in length.	2.52979e-18
NZ_CP013652.1\|WP_062407224.1\|685126_686179_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	9.00336e-83
NZ_CP013652.1\|WP_062407240.1\|698781_699744_+\|2,3-dihydroxybiphenyl-1,2-dioxygenase	gnl\|CDD\|274480	TIGR03211, catechol_2_3, catechol 2,3 dioxygenase. Members of this family all are enzymes active as catechol 2,3 dioxygenase (1.13.11.2), although some members have highly significant activity on catechol derivatives such as 3-methylcatechol, 3-chlorocatechol, and 4-chlorocatechol (see Mars, et al.). This enzyme is also called metapyrocatechase, as it performs a meta-cleavage (an extradiol ring cleavage), in contrast to the ortho-cleavage (intradiol ring cleavage)performed by catechol 1,2-dioxygenase (EC 1.13.11.1), also called pyrocatechase. [Energy metabolism, Other].	3.02622e-108
NZ_CP013652.1\|WP_062407228.1\|688661_691088_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.6601e-77
NZ_CP013652.1\|WP_062407230.1\|691990_693883_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	8.78352e-177
NZ_CP013652.1\|WP_062407232.1\|693898_694759_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|187820	cd09689, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csd2 family.	4.46607e-132
NZ_CP013652.1\|WP_062407254.1\|704055_704496_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	2.38006e-27
NZ_CP013652.1\|WP_062407236.1\|695404_696436_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NZ_CP013652.1\|WP_054820098.1\|691274_691994_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|273847	TIGR01876, cas_Cas5d, CRISPR-associated protein Cas5, subtype I-C/DVULG. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum. This family belongs to a set of several Cas protein families, one each for a number of different CRISPR/Cas subtypes, that share a region of N-terminal sequence similarity modeled by TIGR02593. This family represents the Dvulg subtype of CRISPR/Cas locus.	1.55216e-96
NZ_CP013652.1\|WP_062407234.1\|694748_695408_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.02165e-25
NZ_CP013652.1\|WP_062407253.1\|703513_703999_+\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	9.37502e-57
NZ_CP013652.1\|WP_062407251.1\|702665_703169_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-beta	gnl\|CDD\|238357	cd00667, ring_hydroxylating_dioxygenases_beta, Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the substrate by nonheme iron-containing dioxygenases. These enzymes consist of two or three soluble proteins that interact to form an electron-transport chain that transfers electrons from reduced nucleotides (NADH) via flavin and [2Fe-2S] redox centers to a terminal dioxygenase. Aromatic-ring-hydroxylating dioxygenases oxidize aromatic hydrocarbons and related compounds to cis-arene diols. These enzymes utilize a mononuclear non-heme iron center to catalyze the addition of dioxygen to their respective substrates. The active site of these enzymes however is in the alpha sub-unit. No functional role has been attributed to the beta sub-unit except for a structural role.	4.71994e-44
NZ_CP013652.1\|WP_062407256.1\|704786_706502_+\|arginine--tRNA-ligase	gnl\|CDD\|183534	PRK12451, PRK12451, arginyl-tRNA synthetase; Reviewed.	0
NZ_CP013652.1\|WP_062407226.1\|686736_688263_+\|tripartite-tricarboxylate-transporter-permease	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP013652.1\|WP_074727948.1\|699803_700640_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|132386	TIGR03343, 2-hydroxy-6-oxo-6-phenylhexa-24-dienoate_hydrolase, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase. Members of this family are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, or HOPD hydrolase, the BphD protein of biphenyl degradation. BphD acts on the product of ring meta-cleavage by BphC. Many species carrying bphC and bphD are capable of degrading polychlorinated biphenyls as well as biphenyl itself.	3.69932e-55
NZ_CP013652.1\|WP_054820097.1\|686262_686724_+\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	2.40285e-12

>NZ_CP013652.1|WP_054820100.1|696516_696807_+|CRISPR-associated-endonuclease-Cas2
MLVLVTYDVSTVSSSGRRRLRQVSKICQNYGQRVQNSVFECVVDATQFAVLKLKLLDIIDQEQDSLRFYQLGHNYKSKVEHIGVKESFDLEGLLIL
>NZ_CP013652.1|WP_062407236.1|695404_696436_+|type-I-C-CRISPR-associated-endonuclease-Cas1
MKKLLNTLFITQPDVYLSLDGDNIILLKEQEKLGRLPLHNLESIIAFGYTGASPALMGYCAERNISLVFFTMNGRFLARVIGESKGNVVLRKKQYAISEDEVLSAKIARNFIVGKIYNHKWIIERMTRDYPLRIDVARFKAISQQLSAIMLDVRACEDLERLRGLEGQAAVSYNKLFDSMILQQKEDFYFHSRSRRPPLDNVNAMLSFAYSLLAIDVASALEGVGLDAYVGFLHQDRPGRASLALDVMEELRGVYADKFVLSLINKKMVSNEDFLKKENGAVMMRDEARKKFLTAWQSKKQEKITHPYLGEKISWGLVPHAQALLLARYLRNDLDEYPPFLWK
>NZ_CP013652.1|WP_062407234.1|694748_695408_+|CRISPR-associated-protein-Cas4
MGNNEDDDYLMLSGIQHFQFCKRQWALIHIEQQWEENVRTIEGEYLHQNADQPFVREKRGDKLVVRAMPVKSESLKISGICDVVEFIRDDSGVEINSAEGKYIAYPVEYKRGKPKLNDEDILQLAAQAICLEEMLLCGIDQGYLFYNEIKHRVEVPLTAAIKNKVRLVVAEMQDYYKRRHTPKVKTGSFCRSCSLQHICLPELMSKRTVKSYVEGRIGE
>NZ_CP013652.1|WP_062407232.1|693898_694759_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MTTLDHKIDFAVVLSVTKANPNGDPLNGNRPRQNYDGYGEISDVALKRKIRNRLQDMGESIFVQSNDRRSDSYSSLRERADANAELAKILKSKTSSSDEFARIACREWLDVRSFGQVFAFKADKGAGVSVGVRGPVSIHTATSIDPIDITSMQITKSVNSEPGAAKGSDTMGMKHRVDSGVYVFYGSINTQLAEKTGFTNQDAEKLKQALVTLFENDASSARPEGSMEVHTVYWWEHNSKLGQYSSAKVHRSLTIEKLVEEPKSFTDYKFTVQPLEGLKVESIHGK
>NZ_CP013652.1|WP_062407230.1|691990_693883_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSWLLNLYETYEANLDLVGKIEKKHNDQEYTLLPVSHTTQNAHIEVEITEDGEFHSATVIDKSDASTLIPCTEDSANRAGSKIAPYPLHDKLSYVAGDYAAYGGEIKKEEPFTYYIKQLEDWANSPYGTSKVKSIYHYLSKGRLIQDLVEHKILFIDADNRLIDKWDDKKYEALYGSKPPIFSVISGEQASAFVRFNVYSPNKILTEVWKNQEMYDSFIQFYSSRLGKEDLCYVSGRTLPATDKHANKIRNAGDKAKLISANDTSGFTFRGRFNLSQEAASISYDVSQKAHNALKWLILRQGKTIDQRVFLVWGNDDLDVPGVNEDLYSISPAPIAAKEKKSFTNKEFAVEVAKALDGYRNRLSSSSEVNILILDSATTGRMAVLYYRNLNKELYLDKLTKWHSTCVWLHRYRKDGNGEYVQFYGAPATKDIALAAYGPSASDKTVKGVMERMLPCIIDGRDIPLDIVNSAYHRASNPVSMEKWEWEKTLSIACALINRREGYNVALDTDNNDRNYLFGRLLAVADVLERRALGAEETRATNAIRYMNSFSRHPARTWKTIQNALQPYQARLGTKGTYLSKIIDEVASRIPIAEFNNKPLSEVYLLGFYSQRHELYQKKENNDDAAAASD
>NZ_CP013652.1|WP_054820098.1|691274_691994_+|type-I-C-CRISPR-associated-protein-Cas5
MRNSIEFVVHGAYALFTDPLTKLGGEKLSYQVPTYQSLKGIVESIYWKPTLLMIVDAVRIMNPIRMESKGIRPMDYSGGNTLANYTYLRDVRYQVRAHFEFNMNRPDMAYDRNEHKHHNIMKRSLQAGGRRDIFLGARECQAYVEPCEFGEGDGFYDGYGDIHLGNMVHGINYPDETGRNQLEVRLWNPVMKDGIIQFIRPEQCTQVRVITDMEPKHFNHANVESADELFAQLEEGGNP
>NZ_CP013652.1|WP_062407228.1|688661_691088_+|CRISPR-associated-helicase/endonuclease-Cas3
MNYVAHIRESDNQIQGVEEHLLGVKDLAESYGEKIGVKHIAGLAGMLHDMGKFTHEFREYILEAVRNPDSPPKRGSVDHSTAGGKLLYQLFHTGNPSRLQWILAEVVGNAILSHHSYLHDFLNKDLESPYLKRVQEKQLNEFDRSVQCFFDHVISEAEFHQYVSKALVELEAYLMKPFAGNDESKLMFLTKFIFSALIDADRTNTRLFEENKTHEPEQNRKELFDGYYEKLMAKIHSYQIQDAAKTQMNILRRKMSEQCDQFAGKPSGIYTLSIPTGGGKTLASLRYALKHASLHGKKHIIYVVPYTTIIEQNAEEIRKILMDGGHILEHHSNVIIEDGNEDDENEDGLINTRQKLKLAKDNWDSPIIFTTMVQFLNVFYAKGSRNIRRLHNLSESVIIFDEVQKVPVSCVSLFNQALNFLKTYGHSSLILCTATQPALDFVEHKLALNADAEMIENLDRVIEAFKRVEIIDKATDETFNNNKLADFIAEKMDEVQSVLVILNTKTVVKRLYRQMAGSHVPIYYLSTSMCAAHRNHILEQVREHLEKHEKVICISTQLIEAGVDVSFDCVIRSLAGLDSIAQAAGRCNRHGEREIQQVYVIDHEEEKLDYLPEIKVGKKLSRRILVDLKHDRNHHGGHVLSAQAMDRYFKEFYTEFRSSLNYFIPKLEKDMTELLASNRTHNSYNQAYTHHKKESLPLFIVNSYRTAAEHFYVIDNHTTSVIVPYDDEGKDMIARLNGNESIEDLSRLLRKAQQYTIHLFHYEWAQLAQNGGLVSLIDGKIFALKESAYNKEFGLDLDNDSPFELGMF
>NZ_CP013652.1|WP_062407226.1|686736_688263_+|tripartite-tricarboxylate-transporter-permease
MEVLQFLGSGFITALQWHNLVFAFFGVLIGTAVGVLPGIGPISGVALLIPITASMTSGLSPAEAATSSIILLAGVYYGAMYGGSTTSILLNTPGEASSVVTTLDGHQMAKQGRAGSALSIAAIGSFVAGIVSLLFLVCLAGPLSDLALTFGPAEYFSLMALGLCAVSGLAGKSVTKALIMTILGLLLATVGMDAVSGVARFTFDNPSLYQGFEFLTVAVGLFALGEVFKTILEKDTDDGPISKINRVIPTKQDLKESAAPILRGSFLGFFIGVLPGAGATIASFFAYIMEKKLSKHPEKFGQGAIAGVASPESANNAASGGALIPMLTMGIPGSGTTAILMGALIMYNIQPGPLLFKEHPQVVWGLIASMFIGNVMLLILNMPMVRVFAKIIQTPKKFLLPMIVVISIFGVYAVQASIFDLMLLMLCGVAGIYWTRNDYPLAPLVLGLVLGPMIENNLRRALTISNGDFIIFVQKPVSAVFLLAAALWLIIPVVLKMKGKNVLQSEEG
>NZ_CP013652.1|WP_054820097.1|686262_686724_+|tripartite-tricarboxylate-transporter-TctB-family-protein
MNKSFDRCSSIVYLVTGAAFMLLSQNISTSAYGSEVGPNIFPFGLGLILVLLSLRLLYETFRYPDAAKVKKSLDYKKFGILFVSAVLYAYFLEDLGYVIGTFLFLLIGFQTLEKGKWLISIAVSALLSIGIYYVFVEILQGSLPGFPVWLGWE
>NZ_CP013652.1|WP_062407224.1|685126_686179_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MRKSNWKLGALSAVLLISLTGCGTAKEAGTANANETATKTAAKSNYPVKPITFVAPNGAGGGLDKTARLIVKGLSETKLVTETMTVENKPGGGGSVYMAEYATKETKNPYKLLVNSPPVIINNLKKEGNSPFGYKDTTPLAQLTKDYGAITVPADSKYKDLKALLEDIKADPAKVIIAGGSSPGGMDHLFAMLPVYKYGLDPKAIKYVAYDGGGEAITALLGNHATAAAKPVSLILPYVKSGHVRVLAVTSPERIHTDLLKDVPTLRELGLDADFTIWRGVLGPKEMGKDEIAYWDKVFKELSEKEEWKKLLAEDGVESEYKSAADFKPFLDEQEKLIKEILDVLGMSKN
>NZ_CP013652.1|WP_062407240.1|698781_699744_+|2,3-dihydroxybiphenyl-1,2-dioxygenase
MLVPEIAKLGHVSLVTPDLQKSLWFFKEVLGLEEIERAGGAVYLRACGEFEHHSLVLKQGDRAVVDHIGWRAKRAEDVEKFAVQLEAAGTKIQWIEAGREAGQGKAIQFKLPSQHTFEIYYEVEKPKAPQGERSGLKNQTHKSWARGISPRRIDHVNLWTSHDPGSVHQWLSEQLGFKMREYVKLNNGKVIGGWMSVTQLVHDVAMMGAHDPETPARFHHIAYWLDNAQDVLRALDILRENGIQIDLGPAKHGISQAVCAYVRDPGSGHRVELFSNGYLIFDPDWEPVEWGQEEFGVALQWWGPEYTPGHGHAMDETTEA
>NZ_CP013652.1|WP_074727948.1|699803_700640_+|alpha/beta-fold-hydrolase
MNIRKIKTGSYSTYLCESGEQNSETVIFLHGGGPGVTAESNWRDVLPGFSGSYRVVAPDLAGYGNTDHPDPVPQGGLMGWMRLRVEQILTLMDELDIAKAHLVGNSMGGALALHLVMTAPERFQSVVLMGSAGAPSTPTPEVIRMLNFYKDPTPAALGNLLKWFVYDENIIGDKLNQIVQERFEEVMRPEVRRSYESMFSTSPAEVIVPPSALRRMNMPFLLVHGRDDRFVSVDSSVYMLQHLPNVQLHVFDRCGHWAQLERKESFTKLVTDFFKGEF
>NZ_CP013652.1|WP_062407241.1|700629_701328_+|GntR-family-transcriptional-regulator
MNFKRELVGFVIAMTITPVEKGVADLKKDNAYMYIKNRILDREWDIGSAINVNEICQVLNMSRTPVLEAISRLEREGFLSIIPQVGAFVRRPTSSELFERLLMRGSLEALMVEWAARKIEKTQLDMIDAVLRRMEEPGISIVDYANLNRDFHRIIHEASGLSYIQGLVEEHWDFFEYAAALDKVFKEHRMARSLLEHRMIFHSLKDGNSTLAKQLMEQHVVRVAYLVKEESG
>NZ_CP013652.1|WP_062407243.1|701377_702673_+|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha
MKLLDHYVNLETGSISRKVNYDPEIYQDEMAKIFTKTWLFVAHESQIKHPGDYITNYMAEDPVIVTRDGTGKIHVFLNSCPHRGMKVCSVDAGNSKFFRCPYHGWTFENNGNLIGVPELQYAYYGELDKSKNGLITVPRVESYKGFIFANWDPNALPLKEYFGKDLLWYLDTAFERALGEFEVAGPIMKQKIKTNWKICTENFGDDYHVLYTHGSAFKIGFMPPYDQLGEYNAYCDHGHSVGDIPKFGVGLELDRAIAKQIGPEAEQYVEQIDQRLKERLSPEQANLHQIGQILIFPNLTFLTFGCFRGIHIFQWHPKGTDEVELWQISLYDSEAPDQAKQFARIFSQRENAPAGLFAADDGSNFEQITESTKPYVSRQHHFNYSMGIRHEGEIKVPGLPGHLGRHYSEQNQRNFYRYWLKLMKEEGIFHE
>NZ_CP013652.1|WP_062407251.1|702665_703169_+|aromatic-ring-hydroxylating-dioxygenase-subunit-beta
MNNHLELHKEIELFLYHEAHLLDQSDFEGWLDLFTDDARYWMPTTETRDVDQKQSPLKQEWHLIEDDKPFLHKRYERLQTRLAHAEQPRSRTRRLVTNILIKENHNNQKLLVLSNFIIFQSRRDNEESFFVGRREDTLDRYGDKWKISNRSIFLDQRILPRAISIFF
>NZ_CP013652.1|WP_054818007.1|703199_703400_+|hypothetical-protein
MRITNEFASVMVEIDSNGNSHRLKIQDCRTGRVIYLDALQLESLTRQSDQIFREFLQYPFGPEKEN
>NZ_CP013652.1|WP_062407253.1|703513_703999_+|N-acetyltransferase
MNIRQAVAADLPSILDIYNDAVLHTVVTFDTVPRTMEQQEQWFEQHGKSYPVLVAEDNGLVTGWASLNRYSDRLAYARTAELSLYIRDGYRGHGLGKTMLEAILREGKTAGLHTVLSRITEGNDNSIHIHRVFGFEMVGTMREVGFKFGRLLDVVLMQKML
>NZ_CP013652.1|WP_062407254.1|704055_704496_-|Hsp20/alpha-crystallin-family-protein
MALVPFEPFRRIDHLKKEMDRFFNEGLPAAFGFNQEFGAPRIDVHETENEVIAHCEIAGLDKKEDVDIQVEPHNLTISGTINRFNEVKEEQFHRKERFTGRFHRSIALPAEVMEEGTTASYKNGILEVRMPKAPKETRRRIDVQFH
>NZ_CP013652.1|WP_062407256.1|704786_706502_+|arginine--tRNA-ligase
MNYKQWLAEQLAGKLEGVSRETLAELIEYPPNPQMGDLSLPCFKLSKQLRKAPQAIAEELKAGWSGHALVSRIDAVSGYFNVYLVPEQFASQVVNEVLTQGDRYGAQDIGQGRSVVIDFSSPNIAKTFHIGHLRSTVIGNALYRIFKFMGYNSVGVNHLGDWGTQFGKLIVAYKLWGNREAVEADGIGELQRLYVKFHDEADIHPELEDEARGWFVKLEQGDEEALKLWRWFVDISLKEFQKMYDLLGVTFDSYAGESFYNDKMAAVLEELKAKQLLEEDDGALLVRLDDYQMPPALMVKKDGGTLYHTRDVTAAIYRKNTYDFDKAIYVTDAGQSLHFKQWFKVIELMGYDWAKQLVHVPFGKVSLEGAKLSTRKGNVVNLEELLTKAIEKTREIIDEKNPGMENKDEVAREVGVGAIIFNDLSNNRIKDIVFSWDEALNFDGETGPYVQYTHARACSVLRKAEADGGAAAGAGALAAAHLTNAEAQGVLRELYLFKERIEQAMDRLEPSIISRYLVDLAQKFNHFYHECPILKVEDAELRQARLALVRCVSITLKNGLSLIGLKAPEKI
>NZ_CP013652.1|WP_062407258.1|706576_706771_+|YqzE-family-protein
MEKKEELVKYVTQQVVKYIDTPKEVRKQVKAGKKVGREPWQYRWFGMLPFVLRMWMEPLRRKRG

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Crispr_ID: NZ_CP013652_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013652_2

3553741-3553950

Orphan

Consensus_repeat	Method
CCCNGGCGGACAGCCGGG	CRT

4 spacers

The CRISPR arrays of NZ_CP013652_2

>merge|NZ_CP013652|2|3553741-3553950|CRT
CCCGGGCGGACAGCCGGGCGGATTCCCCGGGGGACAGCCGGGTGGGTTCCCGGGCGGACAGCCGGGTGGATTCCCGGGCGGATTCCCAGGCGGACAGCCGGGCGGATTCCCGGGTGGATTCCCGGGCGGATTCCCAGGCGGGTTCCCGGGCGGACAGCCGGGTGGATTCCCGGGCGGATTCCCAGGCGGGTTCCCAGGCGGGTTCCCGGG

>NZ_CP013652|2|2|3553741-3553950|CRT
CCCGGGCGGACAGCCGGG	CGGATTCCCCGGGGGACAGCCGGGTGGGTT
CCCGGGCGGACAGCCGGG	TGGATTCCCGGGCGGATT
CCCAGGCGGACAGCCGGG	CGGATTCCCGGGTGGATTCCCGGGCGGATTCCCAGGCGGGTT
CCCGGGCGGACAGCCGGG	TGGATTCCCGGGCGGATTCCCAGGCGGGTT
CCCAGGCGGGTTCCCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013652.1\|WP_062409729.1\|3550495_3551446_-\|ring-cleaving-dioxygenase	unknown	unknown	gnl\|CDD\|319935
NZ_CP013652.1\|WP_062409728.1\|3549884_3550499_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223477
NZ_CP013652.1\|WP_062409724.1\|3546467_3546680_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013652.1\|WP_062411041.1\|3556635_3557937_-\|diaminobutyrate--2-oxoglutarate-transaminase	unknown	unknown	gnl\|CDD\|236437
NZ_CP013652.1\|WP_062409736.1\|3559992_3560646_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC	unknown	unknown	gnl\|CDD\|223836
NZ_CP013652.1\|WP_062409730.1\|3551495_3551960_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP013652.1\|WP_062409735.1\|3559326_3559989_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD	unknown	unknown	gnl\|CDD\|132048
NZ_CP013652.1\|WP_054817566.1\|3556229_3556631_-\|ectoine-synthase	unknown	unknown	gnl\|CDD\|183953
NZ_CP013652.1\|WP_062409725.1\|3547794_3548226_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NZ_CP013652.1\|WP_054817563.1\|3563161_3563881_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP013652.1\|WP_054818477.1\|3546755_3547619_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187578
NZ_CP013652.1\|WP_062409738.1\|3561860_3562988_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013652.1\|WP_062409723.1\|3545036_3546230_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP013652.1\|WP_062409737.1\|3560647_3561568_-\|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB	unknown	unknown	gnl\|CDD\|270223
NZ_CP013652.1\|WP_082660868.1\|3555256_3556285_-\|ectoine-hydroxylase	unknown	unknown	gnl\|CDD\|131461
NZ_CP013652.1\|WP_062409734.1\|3558510_3559296_-\|ectoine/hydroxyectoine-ABC-transporter-ATP-binding-protein-EhuA	unknown	unknown	gnl\|CDD\|224051
NZ_CP013652.1\|WP_062409733.1\|3557973_3558495_-\|diaminobutyrate-acetyltransferase	unknown	unknown	gnl\|CDD\|131459
NZ_CP013652.1\|WP_062409727.1\|3549238_3549850_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NZ_CP013652.1\|WP_062409731.1\|3552196_3552997_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319818
NZ_CP013652.1\|WP_062409726.1\|3548325_3548916_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378921

Protein	Function_ID	Function_description	E-value
NZ_CP013652.1\|WP_062409729.1\|3550495_3551446_-\|ring-cleaving-dioxygenase	gnl\|CDD\|319935	cd08347, PcpA_C_like, C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins. The C-terminal domain of Sphingobium chlorophenolicum (formerly Sphingomonas chlorophenolica) 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins. PcpA is a key enzyme in the pentachlorophenol (PCP) degradation pathway, catalyzing the conversion of 2,6-dichloro-p-hydroquinone to 2-chloromaleylacetate. This domain belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	8.50903e-64
NZ_CP013652.1\|WP_062409728.1\|3549884_3550499_-\|alpha/beta-hydrolase	gnl\|CDD\|223477	COG0400, COG0400, Predicted esterase [General function prediction only].	4.74635e-73
NZ_CP013652.1\|WP_062411041.1\|3556635_3557937_-\|diaminobutyrate--2-oxoglutarate-transaminase	gnl\|CDD\|236437	PRK09264, PRK09264, diaminobutyrate--2-oxoglutarate transaminase.	0
NZ_CP013652.1\|WP_062409736.1\|3559992_3560646_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.94774e-68
NZ_CP013652.1\|WP_062409730.1\|3551495_3551960_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.27815e-24
NZ_CP013652.1\|WP_062409735.1\|3559326_3559989_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD	gnl\|CDD\|132048	TIGR03003, ectoine_ehuD, ectoine/hydroxyectoine ABC transporter, permease protein EhuD. Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.	4.69148e-81
NZ_CP013652.1\|WP_054817566.1\|3556229_3556631_-\|ectoine-synthase	gnl\|CDD\|183953	PRK13290, ectC, L-ectoine synthase; Reviewed.	2.583e-81
NZ_CP013652.1\|WP_062409725.1\|3547794_3548226_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	1.1299e-28
NZ_CP013652.1\|WP_054817563.1\|3563161_3563881_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.13913e-30
NZ_CP013652.1\|WP_054818477.1\|3546755_3547619_-\|SDR-family-oxidoreductase	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.13513e-99
NZ_CP013652.1\|WP_062409723.1\|3545036_3546230_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.10344e-73
NZ_CP013652.1\|WP_062409737.1\|3560647_3561568_-\|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB	gnl\|CDD\|270223	cd01002, PBP2_Ehub_like, Substrate binding domain of ectoine/hydroxyectoine specific ABC transport system; the type 2 periplasmic binding protein fold. This family represents the periplasmic substrate-binding component of ABC transport systems that involved in uptake of osmoprotectants (also termed compatible solutes) such as ectoine and hydroxyectoine. To counteract the efflux of water, bacteria and archaea accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.64996e-119
NZ_CP013652.1\|WP_082660868.1\|3555256_3556285_-\|ectoine-hydroxylase	gnl\|CDD\|131461	TIGR02408, putative_L-proline_4-hydroxylase, ectoine hydroxylase. Both ectoine and hydroxyectoine are compatible solvents that serve as protectants against osmotic and thermal stresses. A number of genomes synthesize ectoine. This enzyme allows conversion of ectoine to hydroxyectoine, which may be more effective for some purposes, and is found in a subset of ectoine-producing organisms.	1.95647e-127
NZ_CP013652.1\|WP_062409734.1\|3558510_3559296_-\|ectoine/hydroxyectoine-ABC-transporter-ATP-binding-protein-EhuA	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.59166e-140
NZ_CP013652.1\|WP_062409733.1\|3557973_3558495_-\|diaminobutyrate-acetyltransferase	gnl\|CDD\|131459	TIGR02406, L-24-diaminobutyric_acid_acetyltransferase, diaminobutyrate acetyltransferase. This enzyme family is the EctA of ectoine biosynthesis. Ectoine is a compatible solute, analagous to trehalose, betaines, etc., found often in halotolerant organisms. EctA is L-2,4-diaminobutyric acid acetyltransferase, also called DABA acetyltransferase. [Cellular processes, Adaptations to atypical conditions].	4.79517e-60
NZ_CP013652.1\|WP_062409727.1\|3549238_3549850_-\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	5.32008e-44
NZ_CP013652.1\|WP_062409731.1\|3552196_3552997_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.04329e-82
NZ_CP013652.1\|WP_062409726.1\|3548325_3548916_-\|hypothetical-protein	gnl\|CDD\|378921	pfam12690, BsuPI, Intracellular proteinase inhibitor. This is a bacterial domain which has been named BsuPI in Bacillus subtilis. This domain is found in Bacillus subtilis ipi, where it has been suggested to regulate the major intracellular proteinase (ISP-1) activity in vivo. The structure of proteins in this family adopt a beta barrel topology.	8.30897e-24

>NZ_CP013652.1|WP_062409731.1|3552196_3552997_+|Cof-type-HAD-IIB-family-hydrolase
MYKMLAIDIDDTLINDKKQITEGTKQALSAAVSQGVIVTLATGRMYASAKQLAAELSLNVPLITYMGSLVKNALDGQVLYERTVPLDAARAIFEFCRDRGLHLQTYVDDVLYVQESNEKAEAYAALSKIPYTVYPDFEKLVLMPSAKLLIIDDSEVLDRIAPSLRELAGGSVHMTKSKPHFLEIVHAEGTKGHALSHLAQHFGLELSQVIAIGDSWNDREMLEVAGLGVAMGNAVDALKEIADYVTLSNNDDGIKHVVEKFILQTA
>NZ_CP013652.1|WP_062409730.1|3551495_3551960_-|MarR-family-transcriptional-regulator
MTNGNESKPANNRELSLKLLVVLSKAYKVIMDRAMRDMKKYGLSATEFTVLELLYHKGKIPLQQIGDKILVTSGSITYNIDKLEKKGYLKRVPCSEDRRVTYAVITDAGTDFIRAIFPDHADVIESIMGGLTPEEKADAIVLLKKLGLEAQKIE
>NZ_CP013652.1|WP_062409729.1|3550495_3551446_-|ring-cleaving-dioxygenase
MLQQTMGIHHITAFVTDAQDNVDFYAGVLGLRLVKKTINFDAPEVYHLYFGNEVGSPGTAITFFPWAGARRGRIGGGQVGFTTFVVPQGALAFWEERLQQFNIPFTRTERFSEEYLQFKDKDGLQLEIVEREEGPRSQWAFGGVTPDKAIKGFGGAVLYSNAPDKTMNVLQQVMGLEKIGQENGFVRFKAIGDLGNVIDINAAPVGSGIGGAGTVHHIAWRAKDDEDHQLWRNRLLQNGFQPTPVVDRQYFNAIYFREEGGILFEIATDPPGFALDEPVDALGEKLMLPEWYEPHRAAIEQGLPPIQIRVLGEDKP
>NZ_CP013652.1|WP_062409728.1|3549884_3550499_-|alpha/beta-hydrolase
MKHIFQKGTDPSLPTLVLLHGTGGTENDLLPLAQIIAPAASVLSVRGNVLENGMPRFFRRLAEGVFDEEDLLFRTKELNDFLDQAADEYGLDRHNMVAVGYSNGANIAGSLLFHHKDSLKGAVLHHPMVPRRGAELPDLTGTPVFIGAGRNDPICAPQETEELQHLLEGAGASVTVHWENRGHQLTGSEVQAAADWFSPYLVKQ
>NZ_CP013652.1|WP_062409727.1|3549238_3549850_-|flavin-reductase-family-protein
MISIDPLSQSDRDNYKLMIGSIIPRPVAFVTTLSKKGVLNAAPFSYFNIVTSNPPMVSVSVQRNQGLLKDTARNAQDTGAFVVHISDESYIEKINQTAASLGPEESEVQLAGLSPVPSEKIAVPGVAEAKIRMECVLERSIPLGGSEERPACDLLIGRVVFFHIADELVRNGQIDPEGLKPVSRLAGSSYSKLGDIFSLERPV
>NZ_CP013652.1|WP_062409726.1|3548325_3548916_-|hypothetical-protein
MRKGRMKSVLCFIVIPAVLMACSHDGQQNNFSAESSPSKTAEVHPGRTEELEKEEKQEKEPAKSVTGYFDTTLEAKQEGDRMKFSFSVRNTSGKDLQISYSSGQKYDIYVYNEANEEIYRWSVNKAFTQALIVSSLKKADTLSFTEVWDLKDNQGKRVPKGRYTIQVRVMLNLEDRHAPLSINPDDLSDKMEMELN
>NZ_CP013652.1|WP_062409725.1|3547794_3548226_-|Rrf2-family-transcriptional-regulator
MKKISSRFSIAVHILSLVSLSSSPCTSEFIAASVNTNPVIIRRIIGQLKNAGLVYVKAGTGGTYLRKELDEITLLDVYKAVEVAEKGGLFNFHEHPNPVCPVGANIESVLRKNMIEAQNAMEQRLAQVTLKQLVTELSEKKGF
>NZ_CP013652.1|WP_054818477.1|3546755_3547619_-|SDR-family-oxidoreductase
MSIFITGATGELGGLVIQHLLKKVPANQIVAVVRNVEKASALANLGVEVRHGDYSQPESLQKAFAGADKLLFISSPDSDDTLRIVQHANVVKAARDAGVKYIAYTGFAFAEESNIPLAHVHLATEYMIRTTKIPYTFLRNSLYTEVFVNPGLGASLEQGAIVTNTGSGRLNTVTRGDLALAAAEVLAGEGHENKTYNLVSNQTWSYDELAQIVSEVAGKKIVHQSVSFEEEKNILQGAGFPEPVAALFAGIYHAVSQGETSRTSDDLRKLIGSETPLKETVKQALQG
>NZ_CP013652.1|WP_062409724.1|3546467_3546680_+|hypothetical-protein
MAQRRLLTDQDFQEAMDRQVAVRVFQNDHIVDSGGIIIRFTDTSIVTQSGVSDVTYHQRNACEFFEMKKR
>NZ_CP013652.1|WP_062409723.1|3545036_3546230_-|MFS-transporter
MKQNNNAALIMLMINMFIAMLGIGLIIPVLPDFLKAFDAGGKAAGYLVAAMGLTQFLFSPIAGEWSDKYGRKLMIVSGLALFSFSNFLFAVAHEMWQLYVSRLIGGIGAAAMIPAMLAYVADITSEESRGKGLGMLGAAMSLGFVIGPGIGGFLAELGIRAPFYVSAAVGGFAMLLSLSLLKETRSVEQRQAARLSTERKENIWRQFGKSFKAPYLILLVLIFTLTFGLANFEAVFPLFVDHKYSYTSRDIAVLITVGALIGAVVQAVLIGRLINRFGEKTLINLTFFLSALTMVLMLLSGNFWYILVLTTLFFSFTSILRPAINTLLSKMAGDEQGYVAGMNNAYMSIGNIFGPAVAGILFDVHVNFPYLFGAVILIISLAMSLSWGRRKMSAAVR
>NZ_CP013652.1|WP_082660868.1|3555256_3556285_-|ectoine-hydroxylase
MTKTGCIRHLWKQLKHADKDEYYRLEKELVTVAFDGSNARTKDGIAAVHPRSYENAEDAYPSRIKPVAEFISRKDPVVYSKWTQESPIAREQSDFYEKNGYLFLEDFFTDEEVDVWRKELKRLQEAGRHSNKDEVIREPESREVRSVFAVHRDNPVFRKLSEHSKLLGIVRYLLGSDVYVHQSRINFKPGFNGKEFYWHSDFETWHVEDGMPRMRALSCSIALEDNSYFNGPLMIVPGSHRTFVTCVGETPEDHYRSSLRRQEYGVPDQTSLTELVRQGGIEAPVGKAGSILLFDCNLMHGSSSNISPMPRSNVFLVYNSTENRIVDPFSGQKPRPDYIAAR
>NZ_CP013652.1|WP_054817566.1|3556229_3556631_-|ectoine-synthase
MIVKHLEQVVHTQDDVDTPTWNSRRLLLEKDGMGFSMHDTIIKAGTETLIWYKNHVEAVYCIEGEGEIEVIGGQTYPIRPGTLYALDGHEKHYLRGKTDMRMVCVFNPPLTGREVHDKDGVYPASVEAAEARG
>NZ_CP013652.1|WP_062411041.1|3556635_3557937_-|diaminobutyrate--2-oxoglutarate-transaminase
MKETAEMTSLHVFEELESEVRSYCRSFRTVFSKASNDKLWDVAGREYIDFFAGAGALNYGHNNERIRQKLVQYLLEDGITHSLDMATKAKEDFLIRFQEVILKPRGLQYKVMFPGPTGTNAVESAMKIARKVTGRETVLCFTNAFHGMSLGSLSVTGNKFKRKGAGVALNHSVFMPYDGYFGVDTDTVAYMEKLLDDPGSGVPLPAAVIVETVQGEGGLNVASVPWLKRLEKLCDQRGILLIIDDVQMGCGRTGTFFSFDEAGIRPDIVCLSKSIGGYGLPMALTLIKPELDVWAPGEHNGTFRGNNLAFIAATEALSYWETDAFSVEVIRKAKRVRTFLEEQVKLYPQLQGEVRGKGFIQGIAFADAKKAGLLCEAAFKRRVIMETSGPDSEVAKLMPPLTIDHEVLDLGLQRVSDSMKELAASISSQEKGA
>NZ_CP013652.1|WP_062409733.1|3557973_3558495_-|diaminobutyrate-acetyltransferase
MSHTDTKIIRYRKPRKEDGGKVWELIRSAGALDLNSAYCYIMLCDYFRDTCLVAEQGGRLAGFVSAFRPSGREDTLFVWQIAVASEYRGRGIGKTLLEKLLAQCGERPVHYVEATISPSNQASRQLFGSLARRYNIAFIARKGYPAEIFPGHGSHEEESLYRIGPLQPKPVSV
>NZ_CP013652.1|WP_062409734.1|3558510_3559296_-|ectoine/hydroxyectoine-ABC-transporter-ATP-binding-protein-EhuA
MTDYPVVRYLNIRKSFGDIEVLKGIDLDIAPGEKVALIGPSGSGKTTLGRLLMTLEEPTSGTIEVNGESLWHMKSGGRQVRANEKHLHQMRSSIGMVFQHFNLFPHMTVLRNVTEAPIRVLGLAKEEARERAVLMLRKVGLEEKLDAYPAQLSGGQKQRVAIARALVMRPKVMVFDEVTSALDPELVGEVLEVIKEIASEGEMAMLLITHEMEFARDVADRVVFAADGRIVEEGTPKEVFEHPQSERLQAFLRRFRSTVSV
>NZ_CP013652.1|WP_062409735.1|3559326_3559989_-|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD
MWNWEYTLQILPELLRALKMTVMATAGGFALACAGGLVLALAARSRRKPLALAAKALTAFVRNTPLLVQVFFLYYSLPLIANISLSAFAVGIIGLGLHYSTYLSEVYRSGIEAVPKGQWEAATALNFSKPRTWFSIVLPQAIPPIVPIMGNYLIVMFKETPVLSAITLVELLLTAKNIASVSYRVFEPYTLVGILFLLISFPASLLVRRLEIRLNRQRGL
>NZ_CP013652.1|WP_062409736.1|3559992_3560646_-|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC
MDVSVMSMLPQLLEGAKVTVLVAVLAGCLAFGAAVTAGLCRLSGWRTVRTAAAVYVELFRGTSLLVQLFWLYFALPFLGVELPKLPSAVLAVGLNFGAYGSEIVRSAILAVPKGQWEAATALNMTSYDRMTRIIFPQAFVRMLPPFGNLMIELLKSTSLVYFITLADMTYQAMLLRNQYYPMTPYIFALLLLFYFVLAYIVSLCTRWAERKAASGRM
>NZ_CP013652.1|WP_062409737.1|3560647_3561568_-|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB
MWDSLRQWLNIPLILLLFAAVAGCGTVNDAGAPEGDRPAAAGGNKEGTLARAQEQGYVTVGFANEKPYAYQTADGELTGEAVEIARTVLKNLGINEMRGEFTEFGSLIAGLQAKRFDLITAGMFIHPDRCSAVAFADPEYSIGEAIAVKKGNPLALYSYKDIAGNKSARVAVMAGAVEIGYLEASGVPRDRILVVPDQATAISALQAGRAEAITMTGPSLQSMLDTANDSNLERVSDFQQPIVDGKSVRGYGATAFRQDDQEFKDAFNAELKKLKESGELLTILQKFGFTEDELPGDMTAAKLCGQ
>NZ_CP013652.1|WP_062409738.1|3561860_3562988_-|hypothetical-protein
MSNLMHVCLAALISLGMIRPVPPAAAARPQDHIKVIVKASPESEMITELSVHSRSLMKQLRNLKAGTPQRRTPTDTYIWLQSPEGDVLYAVDEQGDWYDTSRKETLLLKPALKEQMKDYIHAARTAHYGRLVPWKDAKRTVYMKSVVQVVDLETGLRFRAQRRAGSSHADMQPLTKADTGVMKRIYSGEWSWRRRAILVQIDGMSLAASMHGMPHGGDGIPDNAFSGHFCIHFLGSSTHRSANVDPDHQWMVYKAAGRLDEAFKQASPYGVIDSFFVALNQQDPELLRRSFADRENPALHYFIQTIGQIKSIRKISDFNEKDVSGQTRFELPVEVTVHAAGKRPEKQTFTFVLNKASGDAPWQIVSVTYTATSFS
>NZ_CP013652.1|WP_054817563.1|3563161_3563881_+|class-I-SAM-dependent-methyltransferase
MQYLDMLTLLGAGSAHPGGFAATLEQLRRFPLPPKSRVLEVGCGTGRTSCHLVKQGHTVTGLDIRPEMLAKARVRAENEGLQLDFVEGSITALPFDDDTFDIVLAESVTNFADIPSAIKEYHRVLKPGGMLYDREVIISESIPADVFTKLTAFFGFGGLLTEEAWIALLRDHFSDSQVQDRSAFQEHMAADQSIHPDLHQIIDQQAILDAAIWRTSLEHDELILDNRDYISYALLIARK

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Crispr_ID: NZ_CP013652_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013652_3

5034677-5034802

Orphan

Consensus_repeat	Method
GAAGTATGAGAATTGCGATCCTGAGATTTTAACATTCAGGAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013652_3

>merge|NZ_CP013652|3|5034677-5034802|CRISPRCasFinder
GAAGTATGAGAATTGCGATCCTGAGATTTTAACATTCAGGAACACTGAGCAATTTCTTTTCTGCAAAACCAATGAAGTTAAGGAAGTATGAGAATTGCGATCCTGAGATTTTAACATTCAGGAACA

>NZ_CP013652|3|2|5034677-5034802|CRISPRCasFinder
GAAGTATGAGAATTGCGATCCTGAGATTTTAACATTCAGGAACA	CTGAGCAATTTCTTTTCTGCAAAACCAATGAAGTTAAG
GAAGTATGAGAATTGCGATCCTGAGATTTTAACATTCAGGAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013652.1\|WP_062410687.1\|5033253_5034117_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl\|CDD\|274750
NZ_CP013652.1\|WP_054819623.1\|5032783_5033257_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl\|CDD\|376771
NZ_CP013652.1\|WP_054819442.1\|5046369_5046855_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|376377
NZ_CP013652.1\|WP_062410685.1\|5031409_5031592_+\|H-type-small-acid-soluble-spore-protein	unknown	unknown	gnl\|CDD\|377962
NZ_CP013652.1\|WP_062410684.1\|5030152_5031019_-\|Ku-protein	unknown	unknown	gnl\|CDD\|238408
NZ_CP013652.1\|WP_054819625.1\|5031206_5031413_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013652.1\|WP_054819619.1\|5026531_5027962_+\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|234967
NZ_CP013652.1\|WP_054819439.1\|5044130_5044979_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270620
NZ_CP013652.1\|WP_062411139.1\|5029089_5030040_+\|DNA-ligase	unknown	unknown	gnl\|CDD\|185715
NZ_CP013652.1\|WP_062410689.1\|5041545_5041743_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013652.1\|WP_062410692.1\|5043296_5043986_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213022
NZ_CP013652.1\|WP_062411141.1\|5034835_5035882_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NZ_CP013652.1\|WP_145862570.1\|5031719_5032763_+\|thiamine-phosphate-kinase	unknown	unknown	gnl\|CDD\|235583
NZ_CP013652.1\|WP_062410694.1\|5046851_5048054_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
NZ_CP013652.1\|WP_062410695.1\|5048072_5049368_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|176464
NZ_CP013652.1\|WP_062410690.1\|5041831_5042596_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226425
NZ_CP013652.1\|WP_062410688.1\|5034133_5034628_+\|ribosomal-protein-S18-alanine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|273701
NZ_CP013652.1\|WP_062410683.1\|5028079_5028988_-\|DNA-polymerase	unknown	unknown	gnl\|CDD\|182006
NZ_CP013652.1\|WP_062410691.1\|5042731_5043202_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013652.1\|WP_062410693.1\|5045282_5045999_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP013652.1\|WP_062410687.1\|5033253_5034117_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl\|CDD\|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	4.62261e-45
NZ_CP013652.1\|WP_054819623.1\|5032783_5033257_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl\|CDD\|376771	pfam02367, TsaE, Threonylcarbamoyl adenosine biosynthesis protein TsaE. This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).	8.72411e-59
NZ_CP013652.1\|WP_054819442.1\|5046369_5046855_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	4.61198e-91
NZ_CP013652.1\|WP_062410685.1\|5031409_5031592_+\|H-type-small-acid-soluble-spore-protein	gnl\|CDD\|377962	pfam08141, SspH, Small acid-soluble spore protein H family. This family consists of the small acid-soluble spore proteins (SASP) of the H type (sspH). SspH are unique to spores of Bacillus subtilis and are expressed only in the forespore compartment during sporulation of this organism. The sspH genes are monocistronic and are recognized by the forespore-specific sigma factor for RNA polymerase - sigma-G. The specific role of this protein is unclear but is thought to play a role in sporulation under conditions different from that of the common laboratory tests of spore properties.	4.96473e-17
NZ_CP013652.1\|WP_062410684.1\|5030152_5031019_-\|Ku-protein	gnl\|CDD\|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	4.65886e-123
NZ_CP013652.1\|WP_054819619.1\|5026531_5027962_+\|cardiolipin-synthase	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	7.90631e-167
NZ_CP013652.1\|WP_054819439.1\|5044130_5044979_-\|hypothetical-protein	gnl\|CDD\|270620	cd14667, 3D_containing_proteins, Non-mltA associated 3D domain containing proteins, named for 3 conserved aspartate residues. This family contains the 3D domain, named for its 3 conserved aspartates, including similar uncharacterized proteins. These proteins contain the critical active site aspartate of mltA-like lytic transglycosylases where the 3D domain forms a larger domain with the N-terminal region. This domain is also found in conjunction with numerous other domains such as the Escherichia coli MltA, a membrane-bound lytic transglycosylase comprised of 2 domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, corresponding to the 3D domain and Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial LTs, which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond.	5.47015e-33
NZ_CP013652.1\|WP_062411139.1\|5029089_5030040_+\|DNA-ligase	gnl\|CDD\|185715	cd07906, Adenylation_DNA_ligase_LigD_LigC, Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases. Bacterial DNA ligases are divided into two broad classes: NAD-dependent and ATP-dependent. All bacterial species have a NAD-dependent DNA ligase (LigA). Some bacterial genomes contain multiple genes for DNA ligases that are predicted to use ATP as their cofactor, including Mycobacterium tuberculosis LigB, LigC, and LigD. This group is composed of ATP-dependent DNA ligases similar to Mycobacterium tuberculosis LigC. ATP-dependent polynucleotide ligases catalyze phosphodiester bond formation using nicked nucleic acid substrates with the high energy nucleotide of ATP as a cofactor in a three step reaction mechanism. DNA ligases play a vital role in the diverse processes of DNA replication, recombination and repair. Members of this group contain adenylation and C-terminal oligonucleotide/oligosaccharide binding (OB)-fold domains, comprising a catalytic core unit that is common to all members of the ATP-dependent DNA ligase family. The adenylation domain binds ATP and contains many of the active-site residues. The common catalytic core unit comprises six conserved sequence motifs (I, III, IIIa, IV, V and VI) that define this family of related nucleotidyltransferases. LigD consists of a central ATP-dependent DNA ligase catalytic core unit fused to a C-terminal polymerase domain and an N-terminal 3'-phosphoesterase (PE) module. LigD catalyzes the end-healing and end-sealing steps during non-homologous end joining.	4.1045e-72
NZ_CP013652.1\|WP_062410695.1\|5048072_5049368_+\|adenylosuccinate-lyase	gnl\|CDD\|176464	cd01360, Adenylsuccinate_lyase_1, Adenylsuccinate lyase (ASL)_subgroup 1. This subgroup contains bacterial and archeal proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP).	0
NZ_CP013652.1\|WP_062410692.1\|5043296_5043986_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	3.3532e-80
NZ_CP013652.1\|WP_062411141.1\|5034835_5035882_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	0
NZ_CP013652.1\|WP_145862570.1\|5031719_5032763_+\|thiamine-phosphate-kinase	gnl\|CDD\|235583	PRK05731, PRK05731, thiamine monophosphate kinase; Provisional.	2.0222e-116
NZ_CP013652.1\|WP_062410694.1\|5046851_5048054_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	0
NZ_CP013652.1\|WP_062410690.1\|5041831_5042596_-\|AAA-family-ATPase	gnl\|CDD\|226425	COG3910, COG3910, Predicted ATPase [General function prediction only].	1.36952e-90
NZ_CP013652.1\|WP_062410688.1\|5034133_5034628_+\|ribosomal-protein-S18-alanine-N-acetyltransferase	gnl\|CDD\|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR\|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	2.91265e-48
NZ_CP013652.1\|WP_062410683.1\|5028079_5028988_-\|DNA-polymerase	gnl\|CDD\|182006	PRK09633, ligD, DNA ligase D.	1.57849e-94

>NZ_CP013652.1|WP_062410688.1|5034133_5034628_+|ribosomal-protein-S18-alanine-N-acetyltransferase
MERKQETEAIPDSDVQFRAMRREDIPVICEIERESFTTPWTAGAFENELSNNQFAQYIVIEHDGEIAGYGGMWLILEEAHVTNIAIRAKYRGRKLGERLLTEMQRTASFYGAVRMTLEVRPSNKIAQRLYEKKGFRSVGVRRGYYTDNKEDAIIMWADLPKRTV
>NZ_CP013652.1|WP_062410687.1|5033253_5034117_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MITGTGTDQTGRHGGLMLSVDTSTASMTIALTREDKLLGEMTSKAERNHSLHLIPAMKRLMTEVDVKPAELNGFAIGVGPGSYTGVRIGVTAAKTFAWTHKLSLFGVSTLEAMALGGAETAVTGASFGMTGEMSEVRDGELGALDRVLKETERARETVWLIPLIDARRGQAFTALYEAGASGWKCAVPDGIRLMAAWTEELALHAAKHQPDRIVFTGELEQHSEPIRSFASRCAGRVEEMVHGVRARHVAELGRIRWKRGETEDVHGLVPNYTQLAEAEAKLLAQRS
>NZ_CP013652.1|WP_054819623.1|5032783_5033257_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MPLYEYRSRSVGDTSRLAERLASLFIPGTVLTLDGELGAGKTTFSQSVAKAIGVKEIVNSPTFTIIKEYEGERFPFYHMDVYRLSAEEADELGLDEYFYGQGVTLIEWASIIEDLLPPERLAVRIEHDGEQGRRFQLIPYGEPYEEWCLKLKENGYL
>NZ_CP013652.1|WP_145862570.1|5031719_5032763_+|thiamine-phosphate-kinase
MALSSIEEFALIRLLTGGKQSTAFQKAKGVETGIGDDAAVVHVPHGSRLILTCDTMTEEIHFKRVTMRDTDVGYKAMASSVSDIAAMGGTPRFALVALSLPKDAPVERVRAMYEGLYDCASRYGVAIVGGDTTASAGGITLTVTVIGETEADKALLRSAARSGDVVFATGLLGRSAAGLEYLLGLAQPSDVWDTVPEMEMYRPLIQAHCRPEPQVQAGELLRQSGFRHALNDVSDGLASEAWEIAEASGVGIDLNEDQIPVAEELLSYAARVNRDPLDYILYGGEDYQLVGTVPAEHAMELQAAFKTAGLPLYLIGCVNAEHQGVRLVRSSGGALPLGKRGYNHFGS
>NZ_CP013652.1|WP_062410685.1|5031409_5031592_+|H-type-small-acid-soluble-spore-protein
MNLARAQQILNADEKIDVELNGVSVWIDSIDAEEKTAKVHAEHQPADTRVVPVEELEEVK
>NZ_CP013652.1|WP_054819625.1|5031206_5031413_+|hypothetical-protein
MTEANTSGGNNTADTSNEGRDTSFMDIDRMINEGLGGGTVSIHNGLIEESTTDTMDYPESVLNGGDEQ
>NZ_CP013652.1|WP_062410684.1|5030152_5031019_-|Ku-protein
MHTVWKGAISFGLVHVPVKMFSATEDKDISMRMIHKECSTPLNFVRKCQHCEREVEWSEIVRGYEYEPGSFVLFDKDELESLAGEATKEIKILDFVDLSDIDPIYFQKTYYLSPNETGAGAYNLLLEAMKQTGKIGIAKVSIRSKSSLAAIRIIDRCIAMETIFYPDEIRSVDQVPGLPEQVNVNDKELEMAKMLINQLSTEFEPEKYKDDYRTAVMQAIEQKISGQQIRVAPEQRKTNVIDLMAALQASLEAVKPVTPDPAAAAADKPKAAGKKGKAKTKAKETVGS
>NZ_CP013652.1|WP_062411139.1|5029089_5030040_+|DNA-ligase
MKPVIPFEPVSESLVPSEDRWIHQVKWDGVRMLTYYDGRQCRLFNRKLNERTFQYPELTEVQKYCRADSVILDGEIIALGKDGKPSFHEVMKRDGIRKLDRVPQAMRQVPVAYMLFDLLYYDGQWVLNKPLSARLELLNQTIIPGPVIQIVPSYDDGAALFQMTRQQGLEGIVSKELHSTYSINGKDRRWVKVKNYGDIAAVVGGYTLNGGIVNAVLVGVYTAEGKLWYIGHVGTGKLKKSEWVELTAKLKPATIRDKPFDNEHPEMKGAYWVEPKLVVKLQYTEWRWQEGRTLRQPSIQAFIDVPPRECVFDGVL
>NZ_CP013652.1|WP_062410683.1|5028079_5028988_-|DNA-polymerase
MAVTAKHKKTKGALRVDGHELTITNPDKPLWPEKGITKAMYLEKLAQLSPYLLTYCKNRYLTTIRFPHGWNDKSFYQKNAPEPTPDFVKTAVLESINYVHLDSLPTLLWLGNLACLEFHPSFHRIGETLPVEWLIDIDPSVDPEPRIMEAAEIIGEILEGMKIKSVPKTSGATGVQIYVPIPADRGYTFEELRGIGQFVASYAVQKHPKLFTVERLKKDRGTLIYIDYLQHWYGKTLSAPYTPRARKDATVSTPLTWEEVSLRCDPRDFHLLNIIERLQQKGDLIAQLPPQNLDHVLSFIRK
>NZ_CP013652.1|WP_054819619.1|5026531_5027962_+|cardiolipin-synthase
MLWLVIALLLFILQILTILIGEFRHPPKAMAWLFILFIIPVVGCVMYYFLAKEYNRRRKVRRRGLSARSDIRLVGSKLKASDPEWDDNQFKNWRHEQRLFALLNNIPGSQVTYRNEIEVLTNASEAYPAMLEAMEQAKDHIHFEFYTIRDDGVGKQFQDVLIRKAREGVKVRCIFDGIGSYQLSSKFTDELKQAGCEVYFFLPIMIAFFNQRINYRNHRKIVVVDGLKGFVGGINIGDEYLGGNPKLGFWRDTHLKLEGDVVYSLQHTFLVDWLFVSGNRLTDTSLFPEHECRGRKPAQIIDSGPDAHWDAILEMYFGAITAAKKRLYITTPYFIPDASICMGLKTAAISGVDVRIIFPQKSDSSIVNYASMSYFEELLQAGVRFYAYQKGFIHAKVMLIDNLLGTVGTANVDMRSFYSNFELNAVVYDRETLHRLESDFLHDLKDCREIKLEAFEKRSRWQKIKEVMGRILSPLY
>NZ_CP013652.1|WP_062411141.1|5034835_5035882_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MKSHGNEGDSAPVYILAVETSCDETSAAVVRDGREILSNVVSSQVETHKRFGGVVPEVASRKHVESITWILEEALTQAGVQPQQLAAVAVTQGPGLVGSLLVGVVAAKAFACALDLPLIGVHHIAGHIYANELVHKLEYPFMALVVSGGHTELVHVESEGSFRIIGQTRDDAVGEAYDKVGRALKLPYPGGPHIDRLAHEATEAVTLPRAWLEPDSYDFSFSGLKSAVLAVLNQANMKGQPLAPEAVARGFQDSVIDVLVEKAIRAVRKFGAKQLLLAGGVAANKGLRTALETRCRHEGVPLLAPPLSLCTDNAAMIGAAAFLKYRRGQFAALDMKAEPQLKLEGWSV
>NZ_CP013652.1|WP_062410689.1|5041545_5041743_+|hypothetical-protein
MSKVQNNNENEELAELGTHAAGATDLHHTRTTNEAVQIDPPVGNQPGAVDNRSGKFDVKKNGKPI
>NZ_CP013652.1|WP_062410690.1|5041831_5042596_-|AAA-family-ATPase
MVFREQHAYLRSIELLRDRIPSFTAYPFNLPSLRELTSLPLHPKVTYIIGENGMGKSTLLEAAAIAWGFNPEGGSLHFTFSTRSSHSELHRYIRLVRGVRKPKDGFFFRAETYYNLATNIDEMDREQSSAPPIIRSYGDKSLHEQSHGESFFAAFLHRFGGNGLYILDEPEAALSPFKQLSMLARIHALVNRNSQFIISTHSPILMGYPDALMYNLTDKGIEQITLEETDHYIIMKQFLLNRERMLKELFADVE
>NZ_CP013652.1|WP_062410691.1|5042731_5043202_-|hypothetical-protein
MLSFEEKRAVVESFPELERKNVSLGRINYHYEKSAHDKKIVVYHLHPNGNGFVYAGLLYGYDQDDKGLVNIRDFSKEQLHAIIEASIRSLSPRTTEEQAIIGDAKEERWIGPDNHTLVLLEEDEMWYVYSGLHLESAFDTYAEAIEYLHDEGFSRM
>NZ_CP013652.1|WP_062410692.1|5043296_5043986_-|polysaccharide-deacetylase-family-protein
MHRRMCRFMIALVVLFLTGAAPSNSEVVWNVETDQKLIALTFDDGPNPVYTPQILDLLNQYGAKGTFFVIGKRVQMYPAIAIREVNEGHEIANHTFDHHYLKNFPPERLVEEIRQTQEVIFDITEQMPHVFRPPGGFYNDALLQSVKKDQLTVVMWSWYQDTQDWKKPGVDKIVRQVLDNAHNGDIVLFHDLQGDCTQTVEALKQILPELTRRGYQFVTVSDLIAKTRK
>NZ_CP013652.1|WP_054819439.1|5044130_5044979_-|hypothetical-protein
MNFRFKNMLLACVFAVPSVLTASIPAHAQEPVRLADDVKVQVNKKLVAFPDAQPFVDENHKLQVPARAVTDKLGYKLQWEQDGSRFTITIQSSDKTVSLSTGDRSMTVNGKPTQITDPAKFVDGRVYVPFRLISDTFGIKTQWDKINRIAILSTDGQYHAPAWYRPVNKVSKVPNYSKVIVAKATAYTASADENGGYAGLDYMGNPLRLGTIAVDPSVIPLGSKVYVEGYTYDGLPAGGMYATATDTGGAVKGNRIDIFLPESKNKARMFGIQQVKVYILGS
>NZ_CP013652.1|WP_062410693.1|5045282_5045999_+|hypothetical-protein
MYRRDYLMRLIEQTTEVLHKVMFARKNQSLQEALELLNQAMRQLLGLNSRLIHALSTKDLLALLSKDGHVDQGKVLALGDMLNARGAAQKESGHAAAAIKDGLKALDLLLTAREMDPRDELGGMFKERIDAALALANRASMPTDTMHKLVFYYEDCGQYAKSEDVLFHLLDELNEDEHLREEWITVLDEGIRMYERWRSVEEERLAAGNLSKTEVEDGLEELKNIKIKHATIRKNLNE
>NZ_CP013652.1|WP_054819442.1|5046369_5046855_+|5-(carboxyamino)imidazole-ribonucleotide-mutase
MSVLVGVIMGSQSDWETMKHACGVLEELGVPYEKKVVSAHRTPDLMFEYAASAQERGLKVIIAGAGGAAHLPGMVASKTVLPVIGVPVKTSTLNGLDSLLSIVQMPGGVPVATVAIGHAGATNAGLLAAQMLGAFDPELQRKITQRRERIAKTVVEKSVLE
>NZ_CP013652.1|WP_062410694.1|5046851_5048054_+|5-(carboxyamino)imidazole-ribonucleotide-synthase
MTQENMASKAYNPDRVHAPGATIGILGGGQLGRMLALAGRAMGYRFVTLDPMPDAPCGQVADRQIVAEYYDAAAARQLAEQSDVITYEFENVDAGVTSLLMAESYVPQGSRLLYTTQHRLREKRAIEAAGVKVAPYAEIKNEEELREAVRRFGTPCVLKTATGGYDGKGQWIIRSLEEVQEAYDALSKAKTELVLEQFIRFEKEISVIAARSPRGEVKVFPPAENVHVNNILHLSIVPARAPEAVLKKAEAMARQIAEELDVIGLIAVEMFLTADGELYVNELAPRPHNSGHYTMEACRTSQFEQHIRAICNLPLGDTALLSSVVMVNVLGEHVQPLLDWIVNPESERVVPGVTAKLHLYGKHEAKTGRKMGHVNLLSETVEAAFHWIEASHIWESIEKN
>NZ_CP013652.1|WP_062410695.1|5048072_5049368_+|adenylosuccinate-lyase
MINRYTRPEMGAIWTEENKFKAWLEVELLSCEAWSELGVIPKEDVVELRKKASFDIERIYEIEQETRHDVIAFTRAVSETLGPERKWVHYGLTSTDVVDTALGYLLKQANEILERDIINFIDIVRDKAIAYKHTPMMGRTHGVHAEPTTFGLKMALWYEEMKRNLERFRFAADGVQYGKISGAVGTYANIDPFVEEYVCGKLGTKPALISTQTLQRDRHAEYMATLALIATSLDKFATEIRALQKSEFREVEEPFAKGQKGSSAMPHKRNPIGCESISGLARVIRGHMVSAYENVTLWHERDISHSSVERIILPDATILLNYMLNRLGSIVKNLTVFPENMKRNMQSTYGVPFSGRVMTKLIDKGFSREQAYDTVQPRAMQAWEEQRSFREIIENTPAVREVLSLEEIEDAFDPSWHLKHVDTIFKRLGLS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP013652_1	1.4\|697209\|35\|NZ_CP013652\|PILER-CR,CRISPRCasFinder,CRT	697209-697243	35	NZ_CP021083	Deinococcus ficus strain CC-FR2-10 plasmid pDFI2, complete sequence	174789-174823	7	0.8
NZ_CP013652_2	2.4\|3553903\|30\|NZ_CP013652\|CRT	3553903-3553932	30	NZ_MN433457	Pseudomonas aeruginosa strain PAB546 plasmid pNK546-KPC, complete sequence	352108-352137	7	0.767
NZ_CP013652_2	2.4\|3553903\|30\|NZ_CP013652\|CRT	3553903-3553932	30	MF344569	Pseudomonas aeruginosa plasmid p12939-PER, complete sequence	324500-324529	7	0.767
NZ_CP013652_2	2.4\|3553903\|30\|NZ_CP013652\|CRT	3553903-3553932	30	MN583270	Pseudomonas aeruginosa strain NK546 plasmid pNK546b, complete sequence	206955-206984	7	0.767
NZ_CP013652_1	1.7\|697407\|35\|NZ_CP013652\|PILER-CR,CRISPRCasFinder,CRT	697407-697441	35	MK448821	Streptococcus phage Javan623, complete genome	24237-24271	8	0.771
NZ_CP013652_1	1.7\|697407\|35\|NZ_CP013652\|PILER-CR,CRISPRCasFinder,CRT	697407-697441	35	MK448822	Streptococcus phage Javan629, complete genome	27141-27175	8	0.771
NZ_CP013652_1	1.1\|697009\|35\|NZ_CP013652\|PILER-CR,CRISPRCasFinder,CRT	697009-697043	35	NZ_CP022523	Pseudoalteromonas sp. NC201 plasmid pNC201, complete sequence	835388-835422	9	0.743
NZ_CP013652_1	1.7\|697407\|35\|NZ_CP013652\|PILER-CR,CRISPRCasFinder,CRT	697407-697441	35	NZ_CP014913	Lactobacillus paracollinoides strain TMW 1.1979 plasmid pL11979-1, complete sequence	14206-14240	9	0.743
NZ_CP013652_1	1.7\|697407\|35\|NZ_CP013652\|PILER-CR,CRISPRCasFinder,CRT	697407-697441	35	NZ_CP014925	Lactobacillus paracollinoides strain TMW 1.1995 plasmid pL11995-1, complete sequence	16940-16974	9	0.743

1. spacer 1.4|697209|35|NZ_CP013652|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021083 (Deinococcus ficus strain CC-FR2-10 plasmid pDFI2, complete sequence) position: , mismatch: 7, identity: 0.8

agcgacg-ggctgcgcacccttaacgtccaggacaa	CRISPR spacer
-gtgaagtggctgcgcaccctgaacgaccaggagca	Protospacer
 *.** * ************* **** ******  *

2. spacer 2.4|3553903|30|NZ_CP013652|CRT matches to NZ_MN433457 (Pseudomonas aeruginosa strain PAB546 plasmid pNK546-KPC, complete sequence) position: , mismatch: 7, identity: 0.767

tggattcccgggcggattcccaggcgggtt	CRISPR spacer
tggattcgcgggcggattcccaacgaggaa	Protospacer
******* **************.  .**

3. spacer 2.4|3553903|30|NZ_CP013652|CRT matches to MF344569 (Pseudomonas aeruginosa plasmid p12939-PER, complete sequence) position: , mismatch: 7, identity: 0.767

tggattcccgggcggattcccaggcgggtt	CRISPR spacer
tggattcgcgggcggattcccaacgaggaa	Protospacer
******* **************.  .**

4. spacer 2.4|3553903|30|NZ_CP013652|CRT matches to MN583270 (Pseudomonas aeruginosa strain NK546 plasmid pNK546b, complete sequence) position: , mismatch: 7, identity: 0.767

tggattcccgggcggattcccaggcgggtt	CRISPR spacer
tggattcgcgggcggattcccaacgaggaa	Protospacer
******* **************.  .**

5. spacer 1.7|697407|35|NZ_CP013652|PILER-CR,CRISPRCasFinder,CRT matches to MK448821 (Streptococcus phage Javan623, complete genome) position: , mismatch: 8, identity: 0.771

----ctaaaataaaaaatgatttgcgtaaaaaacttgac	CRISPR spacer
aacttcaaaataaa----gatttgcgtaaaaaacttaat	Protospacer
    ..********    ******************.*.

6. spacer 1.7|697407|35|NZ_CP013652|PILER-CR,CRISPRCasFinder,CRT matches to MK448822 (Streptococcus phage Javan629, complete genome) position: , mismatch: 8, identity: 0.771

----ctaaaataaaaaatgatttgcgtaaaaaacttgac	CRISPR spacer
aacttcaaaataaa----gatttgcgtaaaaaacttaat	Protospacer
    ..********    ******************.*.

7. spacer 1.1|697009|35|NZ_CP013652|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022523 (Pseudoalteromonas sp. NC201 plasmid pNC201, complete sequence) position: , mismatch: 9, identity: 0.743

tcttttcggtaaacagcaaaatcaacaatggactt	CRISPR spacer
tcttttcggttaacatcaaaatcaaaaggcaaata	Protospacer
********** **** ********* *.  .* *

8. spacer 1.7|697407|35|NZ_CP013652|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014913 (Lactobacillus paracollinoides strain TMW 1.1979 plasmid pL11979-1, complete sequence) position: , mismatch: 9, identity: 0.743

ctaaaataaaaaatgatttgcgtaaaaaacttgac	CRISPR spacer
atcaaataaaaaatgatttttgtaaaaaatcaggt	Protospacer
 * **************** .********.. *..

9. spacer 1.7|697407|35|NZ_CP013652|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014925 (Lactobacillus paracollinoides strain TMW 1.1995 plasmid pL11995-1, complete sequence) position: , mismatch: 9, identity: 0.743

ctaaaataaaaaatgatttgcgtaaaaaacttgac	CRISPR spacer
atcaaataaaaaatgatttttgtaaaaaatcaggt	Protospacer
 * **************** .********.. *..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1741365 : 1753323

Bacillus_phage(30.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062410923.1\|1741365_1742100_-	site-specific DNA-methyltransferase	A0A1W6JQ19	Staphylococcus_phage	3.3e-75	57.9
WP_062408422.1\|1742207_1742549_-	hypothetical protein	NA	NA	NA	NA
WP_062408423.1\|1742754_1743267_-	hypothetical protein	A0A143FKJ2	Bacillus_phage	1.0e-43	50.3
WP_160327355.1\|1743485_1743656_-	hypothetical protein	NA	NA	NA	NA
WP_062408424.1\|1743690_1743942_-	hypothetical protein	NA	NA	NA	NA
WP_062408425.1\|1743984_1744584_-	hypothetical protein	NA	NA	NA	NA
WP_062408426.1\|1744561_1745008_-	hypothetical protein	NA	NA	NA	NA
WP_145862577.1\|1745096_1745825_-	serine/threonine protein phosphatase	A0A127AVW0	Bacillus_phage	3.4e-48	44.6
WP_062408428.1\|1745856_1746480_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_062408429.1\|1746595_1747153_-	hypothetical protein	NA	NA	NA	NA
WP_062408430.1\|1747255_1747735_-	dihydrofolate reductase	G3MBI7	Bacillus_virus	2.3e-37	46.9
WP_062408431.1\|1747731_1748526_-	thymidylate synthase	A6M9A2	Geobacillus_virus	1.5e-110	68.9
WP_062408432.1\|1748582_1749089_-	hypothetical protein	A0A0H3UZF4	Geobacillus_virus	5.4e-37	51.2
WP_062408433.1\|1749103_1750075_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A0K2FLD5	Brevibacillus_phage	7.1e-102	58.6
WP_062408434.1\|1750102_1752202_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	R4JDX9	Bacillus_phage	1.4e-256	62.9
WP_062408435.1\|1752329_1752683_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	G3MBF1	Bacillus_virus	6.9e-31	53.9
WP_062408436.1\|1752738_1752954_-	hypothetical protein	NA	NA	NA	NA
WP_062408437.1\|1753056_1753323_-	hypothetical protein	A0A0A7RVN5	Clostridium_phage	3.1e-15	46.0

DBSCAN-SWA_2

1764258 : 1778480

Bacillus_phage(33.33%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062408459.1\|1764258_1765503_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	G3MB42	Bacillus_virus	1.3e-52	36.4
WP_062408460.1\|1765884_1766712_-\|protease	spore protease YyaC	G3M9W0	Bacillus_virus	1.3e-24	41.6
WP_062408461.1\|1766733_1767027_-	hypothetical protein	NA	NA	NA	NA
WP_062408462.1\|1767410_1768499_-	hypothetical protein	A0A218KBY7	Bacillus_phage	6.8e-61	41.2
WP_062408463.1\|1768522_1770007_-	hypothetical protein	Q332G8	Clostridium_botulinum_C_phage	1.3e-51	32.3
WP_062408464.1\|1770071_1770632_-	hypothetical protein	A0A0K2FML1	Brevibacillus_phage	1.4e-14	30.3
WP_062408465.1\|1770669_1770867_-	hypothetical protein	NA	NA	NA	NA
WP_062408466.1\|1770941_1772267_-	DNA cytosine methyltransferase	Q02778	Bacillus_phage	2.9e-61	33.1
WP_062408467.1\|1772296_1772680_-	hypothetical protein	A0A172JHZ7	Bacillus_phage	3.9e-19	43.1
WP_062408468.1\|1772843_1774013_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	Q331V1	Clostridium_botulinum_C_phage	6.1e-124	60.5
WP_062408469.1\|1773954_1774605_-\|transposase	IS607 family transposase	Q331V0	Clostridium_botulinum_C_phage	1.6e-86	72.0
WP_062408470.1\|1774792_1775308_-	siphovirus Gp157 family protein	Q9MBS3	Staphylococcus_prophage	8.6e-06	32.6
WP_062408471.1\|1775345_1775741_-	hypothetical protein	A0A191ZC55	Erwinia_phage	6.2e-12	37.7
WP_160327357.1\|1775841_1776018_-	hypothetical protein	NA	NA	NA	NA
WP_062408472.1\|1776049_1776232_-	hypothetical protein	NA	NA	NA	NA
WP_062408473.1\|1776424_1776934_-	hypothetical protein	NA	NA	NA	NA
WP_062408474.1\|1776973_1777237_-	hypothetical protein	NA	NA	NA	NA
WP_062408475.1\|1777278_1777521_-	hypothetical protein	NA	NA	NA	NA
WP_062408476.1\|1777544_1777763_-	hypothetical protein	NA	NA	NA	NA
WP_062408477.1\|1777790_1778018_-	hypothetical protein	NA	NA	NA	NA
WP_062408478.1\|1778132_1778480_-	hypothetical protein	A0A0K1LMG2	Bacillus_phage	1.2e-08	36.7

DBSCAN-SWA_3

1787826 : 1794767

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062408500.1\|1787826_1788021_-	hypothetical protein	A0A0F6WCP2	Sinorhizobium_phage	1.5e-11	60.0
WP_062408501.1\|1788017_1788224_-	hypothetical protein	NA	NA	NA	NA
WP_062408502.1\|1788757_1789309_-	hypothetical protein	A0A217ERD3	Bacillus_phage	3.5e-53	56.1
WP_062408503.1\|1789354_1790458_-	hypothetical protein	A0A0A8WIQ4	Clostridium_phage	1.8e-80	44.4
WP_062408504.1\|1790691_1791273_-	hypothetical protein	B4UTT6	Rhizobium_phage	9.4e-25	45.5
WP_062408505.1\|1791256_1791910_-	dTMP kinase	NA	NA	NA	NA
WP_062408506.1\|1791867_1792134_-	hypothetical protein	NA	NA	NA	NA
WP_062408507.1\|1792138_1792825_-	transglycosylase SLT domain-containing protein	NA	NA	NA	NA
WP_062408508.1\|1792960_1793965_-	ATP-binding protein	A0A1P8CX29	Bacillus_phage	1.1e-105	60.4
WP_062408509.1\|1794002_1794767_-	hypothetical protein	A0A0A8WEV5	Clostridium_phage	1.8e-36	40.0

DBSCAN-SWA_4

1845491 : 1860477

Bacillus_phage(40.0%)

integrase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062408591.1\|1845491_1847837_-	AAA family ATPase	A0A0H3UZA5	Geobacillus_virus	8.9e-175	43.4
WP_160327366.1\|1847861_1848017_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_062408592.1\|1848281_1849331_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_062408593.1\|1849574_1849796_+	hypothetical protein	NA	NA	NA	NA
WP_145862580.1\|1849982_1852586_+	hypothetical protein	H7BV05	unidentified_phage	2.6e-252	51.9
WP_062408595.1\|1852566_1853334_+	hypothetical protein	Q331U9	Clostridium_botulinum_C_phage	4.0e-39	37.1
WP_062408596.1\|1853486_1853813_+	HU family DNA-binding protein	A0A1P8CWT5	Bacillus_phage	8.4e-15	47.6
WP_062408597.1\|1853923_1855165_+	hypothetical protein	V9VF25	Lactococcus_phage	2.3e-89	43.9
WP_062408598.1\|1855195_1855393_+	hypothetical protein	A0A1P8CWT3	Bacillus_phage	2.5e-06	41.0
WP_062408599.1\|1855397_1856585_+	hypothetical protein	A0A060AB19	Staphylococcus_phage	2.2e-49	33.8
WP_062408600.1\|1856601_1856847_+	hypothetical protein	NA	NA	NA	NA
WP_062408601.1\|1856910_1857516_+	hypothetical protein	A0A0U4B0J0	Pseudomonas_phage	2.2e-08	27.8
WP_062408602.1\|1857721_1858633_+	hypothetical protein	A0A1P8CWS6	Bacillus_phage	1.5e-40	34.2
WP_062408603.1\|1858635_1860477_+	hypothetical protein	O64069	Bacillus_phage	2.5e-140	46.8

DBSCAN-SWA_5

1869841 : 1897626

Brevibacillus_phage(46.15%)

integrase,tail

attL 1871202:1871218|attR 1883400:1883416

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062408614.1\|1869841_1870618_+	hypothetical protein	A0A0H3UZ43	Geobacillus_virus	1.3e-26	30.6
WP_062408615.1\|1871021_1871522_+	hypothetical protein	NA	NA	NA	NA
1871202:1871218	attL	NA	NA	NA	NA
WP_062408616.1\|1871490_1871928_+	hypothetical protein	NA	NA	NA	NA
WP_062408617.1\|1871940_1872954_+\|integrase	tyrosine-type recombinase/integrase	A0A0A7DMS1	Lactobacillus_phage	6.8e-63	42.7
WP_062408618.1\|1872972_1873158_+	hypothetical protein	NA	NA	NA	NA
WP_062408619.1\|1873460_1880150_+\|tail	phage tail tape measure protein	A0A1P8CWQ1	Bacillus_phage	1.6e-91	30.7
WP_062408620.1\|1880153_1880738_+\|tail	phage tail protein	A0A0K2FMB9	Brevibacillus_phage	7.6e-51	51.0
WP_062408621.1\|1880756_1881392_+	hypothetical protein	A0A0K2FLS3	Brevibacillus_phage	1.4e-42	41.5
WP_062408622.1\|1881408_1882053_+	hypothetical protein	U5J9C3	Bacillus_phage	1.2e-09	35.1
WP_062408623.1\|1882064_1885901_+	hypothetical protein	A0A0K2FLF6	Brevibacillus_phage	5.6e-09	57.1
1883400:1883416	attR	NA	NA	NA	NA
WP_062408624.1\|1885999_1886728_+	hypothetical protein	NA	NA	NA	NA
WP_160327367.1\|1887110_1887254_+	hypothetical protein	NA	NA	NA	NA
WP_062408625.1\|1887250_1887649_+	type II toxin-antitoxin system death-on-curing family toxin	NA	NA	NA	NA
WP_145862523.1\|1887800_1888136_+	hypothetical protein	NA	NA	NA	NA
WP_062408626.1\|1888146_1888473_+	hypothetical protein	NA	NA	NA	NA
WP_062408627.1\|1888485_1889637_+	hypothetical protein	A0A0K2FMC4	Brevibacillus_phage	8.3e-49	31.6
WP_062408628.1\|1889655_1890120_+	hypothetical protein	G3MAA2	Bacillus_virus	4.2e-44	61.0
WP_062408629.1\|1890205_1890820_+	hypothetical protein	G3MAA3	Bacillus_virus	2.2e-48	50.8
WP_145862524.1\|1890884_1891550_+	hypothetical protein	A0A0K2FLT2	Brevibacillus_phage	5.3e-24	35.9
WP_062408630.1\|1891555_1893982_+	discoidin domain-containing protein	A0A0K2CPK6	Brevibacillus_phage	5.4e-58	36.8
WP_062408631.1\|1894016_1895810_+	DNRLRE domain-containing protein	NA	NA	NA	NA
WP_062408632.1\|1895940_1896477_+	hypothetical protein	NA	NA	NA	NA
WP_062408633.1\|1896565_1896886_+	hypothetical protein	NA	NA	NA	NA
WP_145862581.1\|1896900_1897626_+	N-acetylmuramoyl-L-alanine amidase	D6QWN1	uncultured_phage	2.8e-63	63.9

DBSCAN-SWA_6

2293738 : 2299663

Staphylococcus_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_054819898.1\|2293738_2294353_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	3.6e-19	32.8
WP_062408901.1\|2294321_2295107_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	1.1e-07	31.0
WP_062408902.1\|2295144_2295615_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.4e-42	59.5
WP_062408903.1\|2295644_2296865_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	4.9e-116	53.3
WP_054819897.1\|2296905_2297571_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	2.4e-40	44.8
WP_137669833.1\|2297574_2298717_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	2.0e-58	40.0
WP_062408906.1\|2299231_2299663_-	peptidylprolyl isomerase	A0A1B1IVS0	uncultured_Mediterranean_phage	1.1e-22	44.9

DBSCAN-SWA_7

2755379 : 2813459

uncultured_Mediterranean_phage(23.08%)

integrase,coat,protease,tRNA,transposase

attL 2750567:2750580|attR 2761566:2761579

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2750567:2750580	attL	NA	NA	NA	NA
WP_062410984.1\|2755379_2756669_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_062409214.1\|2757027_2759265_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_062409215.1\|2759275_2760433_-\|integrase	tyrosine-type recombinase/integrase	A0A2H4JCB7	uncultured_Caudovirales_phage	3.0e-06	26.6
WP_062409217.1\|2761631_2762384_-\|tRNA	tRNA threonylcarbamoyladenosine dehydratase	NA	NA	NA	NA
2761566:2761579	attR	NA	NA	NA	NA
WP_062409218.1\|2762415_2764200_-\|tRNA	aspartate--tRNA ligase	A0A2K9L3L6	Tupanvirus	1.2e-14	23.1
WP_062409219.1\|2764244_2765504_-\|tRNA	histidine--tRNA ligase	A0A2K9L6G5	Tupanvirus	9.1e-17	24.1
WP_062409220.1\|2766000_2767959_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_062409221.1\|2768078_2769614_-	coproporphyrinogen III oxidase	NA	NA	NA	NA
WP_054819007.1\|2769717_2769900_-	hypothetical protein	NA	NA	NA	NA
WP_062409222.1\|2770006_2770453_-\|tRNA	D-tyrosyl-tRNA(Tyr) deacylase	NA	NA	NA	NA
WP_062409223.1\|2770493_2772686_-	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	J9Q7H7	Salmonella_phage	1.7e-10	38.7
WP_054819008.1\|2772917_2773982_-\|coat	spore coat protein CotH	NA	NA	NA	NA
WP_062409224.1\|2774143_2774656_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.3e-32	47.3
WP_062409225.1\|2774652_2777085_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	1.7e-88	33.9
WP_054819010.1\|2777102_2778047_-	cation transporter	NA	NA	NA	NA
WP_082660809.1\|2778123_2779035_-	protein translocase subunit SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	3.9e-33	37.1
WP_082660810.1\|2779024_2780257_-	protein translocase subunit SecD	NA	NA	NA	NA
WP_082660811.1\|2780370_2780907_-	hypothetical protein	NA	NA	NA	NA
WP_062409226.1\|2781071_2782631_+	stage V sporulation protein B	NA	NA	NA	NA
WP_062409227.1\|2782647_2783322_-	DUF421 domain-containing protein	NA	NA	NA	NA
WP_062409228.1\|2783564_2783924_+	TIGR04086 family membrane protein	NA	NA	NA	NA
WP_062409229.1\|2784011_2784329_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	1.6e-07	41.2
WP_062409230.1\|2784368_2785502_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	4.4e-87	45.3
WP_054819013.1\|2785535_2786585_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_074727218.1\|2786595_2788656_-	SpoIID/LytB domain-containing protein	Q2XU88	Pseudomonas_phage	5.5e-11	34.3
WP_062409231.1\|2788800_2789805_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	3.8e-05	29.7
WP_062409232.1\|2789866_2790505_-	Holliday junction branch migration protein RuvA	NA	NA	NA	NA
WP_062409233.1\|2790501_2791005_-	crossover junction endodeoxyribonuclease RuvC	NA	NA	NA	NA
WP_062409234.1\|2791188_2791857_-	HNH endonuclease	G8EY24	Synechococcus_phage	3.5e-07	40.0
WP_062409235.1\|2791998_2792655_-	hypothetical protein	NA	NA	NA	NA
WP_062409236.1\|2792772_2793477_-	bypass-of-forespore protein C	NA	NA	NA	NA
WP_062409237.1\|2793610_2794159_+	signal peptidase I	NA	NA	NA	NA
WP_062409239.1\|2794897_2795542_-	hypothetical protein	NA	NA	NA	NA
WP_062409240.1\|2795719_2796748_-\|transposase	IS1595-like element ISPana1 family transposase	NA	NA	NA	NA
WP_062409241.1\|2796904_2799382_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_062409242.1\|2799586_2800465_-	branched-chain-amino-acid transaminase	NA	NA	NA	NA
WP_062409243.1\|2800471_2801356_-	prephenate dehydratase	NA	NA	NA	NA
WP_062409244.1\|2801352_2802333_-	homoserine kinase	NA	NA	NA	NA
WP_062409245.1\|2802457_2803744_-	homoserine dehydrogenase	NA	NA	NA	NA
WP_054819709.1\|2803761_2804235_-	ACT domain-containing protein	NA	NA	NA	NA
WP_054819708.1\|2804379_2804883_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_062409246.1\|2804979_2805765_+	ABC transporter ATP-binding protein	F2Y302	Organic_Lake_phycodnavirus	1.4e-10	26.9
WP_062409247.1\|2805837_2806893_-	anthranilate phosphoribosyltransferase	NA	NA	NA	NA
WP_062410986.1\|2806960_2809090_-	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_054819706.1\|2809132_2810365_-	NarK/NasA family nitrate transporter	NA	NA	NA	NA
WP_062409248.1\|2810672_2811974_-	GTPase ObgE	NA	NA	NA	NA
WP_082660813.1\|2811963_2812632_-	hypothetical protein	NA	NA	NA	NA
WP_054819705.1\|2812801_2813113_-	50S ribosomal protein L27	NA	NA	NA	NA
WP_054819704.1\|2813132_2813459_-\|protease	ribosomal-processing cysteine protease Prp	NA	NA	NA	NA

DBSCAN-SWA_8

5048072 : 5058137

Mollivirus(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062410695.1\|5048072_5049368_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.0e-18	33.3
WP_062410696.1\|5049390_5050281_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	3.8e-41	33.0
WP_054819443.1\|5050336_5050585_+	phosphoribosylformylglycinamidine synthase subunit PurS	A0A0E3FJ99	Synechococcus_phage	2.0e-08	37.5
WP_062410697.1\|5050605_5051301_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_062410698.1\|5051278_5053522_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.6e-166	41.9
WP_082660949.1\|5053506_5055048_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.0e-49	31.9
WP_062410699.1\|5055283_5056324_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.7e-72	46.7
WP_054819445.1\|5056320_5056953_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.8e-28	41.2
WP_062410700.1\|5056949_5058137_+	phosphoribosylaminoimidazolecarboxamide formyltransferase	S4VT61	Pandoravirus	8.1e-15	24.6

DBSCAN-SWA_9

5084662 : 5114159

Brevibacillus_phage(16.67%)

integrase,transposase

attL 5078050:5078064|attR 5111961:5111975

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
5078050:5078064	attL	NA	NA	NA	NA
WP_062410719.1\|5084662_5085865_-\|integrase	site-specific integrase	S5MNZ2	Brevibacillus_phage	7.9e-135	58.6
WP_062410720.1\|5085865_5086282_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_062410721.1\|5086401_5086590_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_062410722.1\|5086641_5087823_+	hypothetical protein	NA	NA	NA	NA
WP_062410723.1\|5087819_5089940_+	DUF927 domain-containing protein	NA	NA	NA	NA
WP_062410724.1\|5089980_5090403_+	hypothetical protein	NA	NA	NA	NA
WP_062410725.1\|5090432_5091272_-\|integrase	tyrosine-type recombinase/integrase	A0A1B1P7C7	Bacillus_phage	1.6e-49	40.3
WP_062410726.1\|5091353_5091767_-	hypothetical protein	NA	NA	NA	NA
WP_062410727.1\|5091782_5093669_-	hypothetical protein	G1DAY1	Mycobacterium_virus	5.0e-11	29.1
WP_160327413.1\|5093643_5093808_-	hypothetical protein	NA	NA	NA	NA
WP_062410728.1\|5093872_5094304_-	hypothetical protein	NA	NA	NA	NA
WP_062410730.1\|5095700_5097059_+\|transposase	transposase	NA	NA	NA	NA
WP_062410731.1\|5097146_5098376_-	S-layer homology domain-containing protein	NA	NA	NA	NA
WP_062410732.1\|5098558_5099479_-	copper amine oxidase N-terminal domain-containing protein	NA	NA	NA	NA
WP_062410733.1\|5099609_5099801_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_082660953.1\|5099858_5100677_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_062410735.1\|5100744_5101068_-	hypothetical protein	NA	NA	NA	NA
WP_062410736.1\|5101470_5102076_-	hypothetical protein	NA	NA	NA	NA
WP_160327414.1\|5102047_5102185_-	hypothetical protein	NA	NA	NA	NA
WP_062410737.1\|5102742_5106684_+	hypothetical protein	NA	NA	NA	NA
WP_062410738.1\|5106951_5107506_+	hypothetical protein	NA	NA	NA	NA
WP_062410739.1\|5107581_5108412_+	hypothetical protein	NA	NA	NA	NA
WP_062410740.1\|5110120_5110741_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_062410741.1\|5110742_5111057_-	hypothetical protein	NA	NA	NA	NA
WP_062410742.1\|5111049_5111649_-\|integrase	tyrosine-type recombinase/integrase	A0A218M9P0	Mycobacterium_phage	5.0e-05	42.6
WP_062410743.1\|5111850_5112600_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.4e-41	38.5
5111961:5111975	attR	NA	NA	NA	NA
WP_145862571.1\|5112596_5114159_-\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	2.6e-13	26.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP013652

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection