CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP012030	Leptospira borgpetersenii serovar Ballum strain 56604 chromosome 2, complete sequence	1 crisprs	csa3	1	1
NZ_CP012031	Leptospira borgpetersenii serovar Ballum strain 56604 plasmid lbp1, complete sequence	0 crisprs	NA	0	0
NZ_CP012032	Leptospira borgpetersenii serovar Ballum strain 56604 plasmid lbp2, complete sequence	0 crisprs	NA	0	0
NZ_CP012029	Leptospira borgpetersenii serovar Ballum strain 56604 chromosome 1, complete sequence	3 crisprs	cas3,DinG,csa3,Cas9_archaeal,cse2gr11,cas7,cas5,cas6e,cas1,cas2,WYL	4	2

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012030_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012030_1

332906-333003

Orphan

Consensus_repeat	Method
TTTACCGTATTAGCGGTTTTTAAATCCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012030_1

>merge|NZ_CP012030|1|332906-333003|CRISPRCasFinder
TTTACCGTATTAGCGGTTTTTAAATCCTCTTTGTTGGAAACGGAGGAAAGAAAATCATAAACTTCCTTGTTTACCGTATTAGCGGTTTTTAAATCCTC

>NZ_CP012030|1|1|332906-333003|CRISPRCasFinder
TTTACCGTATTAGCGGTTTTTAAATCCTC	TTTGTTGGAAACGGAGGAAAGAAAATCATAAACTTCCTTG
TTTACCGTATTAGCGGTTTTTAAATCCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012030.1\|WP_002739652.1\|337916_338225_-\|4a-hydroxytetrahydrobiopterin-dehydratase	unknown	unknown	gnl\|CDD\|234845
NZ_CP012030.1\|WP_026054004.1\|321386_321875_-\|DUF2505-family-protein	unknown	unknown	gnl\|CDD\|378476
NZ_CP012030.1\|WP_000849259.1\|336621_337347_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP012030.1\|WP_002733458.1\|325240_326041_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012030.1\|WP_058331125.1\|334643_335591_-\|elongation-factor-P--(R)-beta-lysine-ligase	unknown	unknown	gnl\|CDD\|273090
NZ_CP012030.1\|WP_002739662.1\|330246_330909_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP012030.1\|WP_002724931.1\|338504_338918_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237177
NZ_CP012030.1\|WP_002724940.1\|339167_339446_+\|DUF883-family-protein	unknown	unknown	gnl\|CDD\|377576
NZ_CP012030.1\|WP_002739780.1\|323182_324313_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|214724
NZ_CP012030.1\|WP_002739591.1\|333446_334583_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_CP012030.1\|WP_002724919.1\|339843_340101_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012030.1\|WP_002725362.1\|319951_320146_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012030.1\|WP_002733362.1\|329384_329978_+\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|381594
NZ_CP012030.1\|WP_002724906.1\|335638_335974_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012030.1\|WP_002724929.1\|339463_339847_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012030.1\|WP_032854458.1\|326965_329281_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP012030.1\|WP_002739706.1\|326303_326969_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012030.1\|WP_002739540.1\|324332_325244_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012030.1\|WP_002724923.1\|335986_336394_-\|DUF4279-domain-containing-protein	unknown	unknown	gnl\|CDD\|372913
NZ_CP012030.1\|WP_026054005.1\|321993_323133_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481

Protein	Function_ID	Function_description	E-value
NZ_CP012030.1\|WP_002739652.1\|337916_338225_-\|4a-hydroxytetrahydrobiopterin-dehydratase	gnl\|CDD\|234845	PRK00823, phhB, pterin-4-alpha-carbinolamine dehydratase; Validated.	1.09536e-22
NZ_CP012030.1\|WP_026054004.1\|321386_321875_-\|DUF2505-family-protein	gnl\|CDD\|378476	pfam10698, DUF2505, Protein of unknown function (DUF2505). Members of this family are all Actinobacteria. The function is not known.	9.16865e-05
NZ_CP012030.1\|WP_000849259.1\|336621_337347_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.13958e-82
NZ_CP012030.1\|WP_002724940.1\|339167_339446_+\|DUF883-family-protein	gnl\|CDD\|377576	pfam05957, DUF883, Bacterial protein of unknown function (DUF883). This family consists of several hypothetical bacterial proteins of unknown function.	8.60054e-10
NZ_CP012030.1\|WP_058331125.1\|334643_335591_-\|elongation-factor-P--(R)-beta-lysine-ligase	gnl\|CDD\|273090	TIGR00462, genX, EF-P lysine aminoacylase GenX. Many Gram-negative bacteria have a protein closely homologous to the C-terminal region of lysyl-tRNA synthetase (LysS). Multiple sequence alignment of these proteins with the homologous regions of collected LysS proteins shows that these proteins form a distinct set rather than just similar truncations of LysS. The protein is termed GenX after its designation in E. coli. Interestingly, genX often is located near a homolog of lysine-2,3-aminomutase. Its function is unknown. [Unknown function, General].	1.79096e-104
NZ_CP012030.1\|WP_002739662.1\|330246_330909_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.76432e-15
NZ_CP012030.1\|WP_002724931.1\|338504_338918_-\|hypothetical-protein	gnl\|CDD\|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	0.00483138
NZ_CP012030.1\|WP_002739780.1\|323182_324313_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|214724	smart00563, PlsC, Phosphate acyltransferases. Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.	4.92393e-10
NZ_CP012030.1\|WP_002739591.1\|333446_334583_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	1.24521e-30
NZ_CP012030.1\|WP_002733362.1\|329384_329978_+\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|381594	cd00254, LT-like, lytic transglycosylase(LT)-like domain. Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	1.30176e-49
NZ_CP012030.1\|WP_032854458.1\|326965_329281_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.1008e-49
NZ_CP012030.1\|WP_002724923.1\|335986_336394_-\|DUF4279-domain-containing-protein	gnl\|CDD\|372913	pfam14106, DUF4279, Domain of unknown function (DUF4279). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	7.66799e-13
NZ_CP012030.1\|WP_026054005.1\|321993_323133_+\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	7.56037e-143

>NZ_CP012030.1|WP_002739662.1|330246_330909_+|TetR/AcrR-family-transcriptional-regulator
MKDNFVSEVTIRKRNRAATETSILLAAIQVFAKKGYDAANTKDIAKLANANEALIFRYFGNKKGLLEAILTRSEDIKQENSLSSRVRKTSKNYQDLEASIRYLISGKCKDFKDAEDFMKVAVSQIILDPEVSQIIQKKIYTKALPEFITELEKFKKAGKINPKTDLKSAAYAISSFAFALGFMGQCVYKIPPSEIQATIKEVARIFRKGLEPGPTKKKSK
>NZ_CP012030.1|WP_002733362.1|329384_329978_+|lytic-transglycosylase-domain-containing-protein
MRIEELPPVQKILNRIQDIESLANRFVKETPVQNRQEPFDSMLKAEGEKSASNPKIEPWRTNSRGNWEGIEPTLAEIIRKESEKNHLDPSLVQSVIKAESGFKTDAISPKGAIGLMQLMPSTANLLGVDDPSDPAENVAGGTKFLSDLLNKYRNLDHALAAYNAGPKAVDHYGGIPPYKETKKYVEKVKKFYRDFSE
>NZ_CP012030.1|WP_032854458.1|326965_329281_-|ABC-transporter-substrate-binding-protein
MSSVIEIAITSRISAFPILYAKSRGFFEKEGIQVQIRVLENYDAILAFLSSGKIEVGEIPFTTWLDLHLKKTVPNKSIFRGMILSRMIHSFYSKYNSSMDSILEGTPYLIPVLQNTSVDKLLAQEFMRSSRFRKKISYTFVYSRSYLLEYEFAQTTTLGLIGSVQESHFLNNGFRISEGRDLPPYRLPVNMLAFNGRFAKTYPDRINKLQSALFRAIQSLIENTSDTTEHVIQENIPEFKIEPEQLHYFYKQPSQDLQEILSPVAALEELEYLGRIYWRSIKHLTDPPPVLLEALDLAAKDPIPIYPAALKTKKTVLMEEQFNREDESNRLLEITGDRRELGDLVSDVHNLVLNIYNSKKGVRLPVLPLKGTAPAIRTGINSILDFLFQEIRTQEIKALAIDNVLMMQGLEMDKRNMELQFSDDRFNYLFEFSPIPVILLDSVSGALIAGNYNFRSLTSYSKDNIHSLRLEDLFPGLEEMGDWSSPTKSPETMLRVDQVKMKLRDKSEMDVSLSITALFERARKIYQVHILYDSEKKETEQAKHEFISNISHELRSPMTNIQGYFELLRAEINTFLSKDQSGMLNVIEKNIKRLNHLIENLLKFEEVQGEDNSGLVENFDPALVIEEVVYSNEPSAKEKGLGVELNLIKKLKVRGIRFEFSQVITNLFVNAIKYTEKGKIEMTMIESGEGTIEINIKDTGVGIDPKYVEKVFERFFRVPNDRNKRVGGTGLGLPISRTILHKMNGEITLESRVGGGSNFKISLPLQSSDSK
>NZ_CP012030.1|WP_002739706.1|326303_326969_-|hypothetical-protein
MSRKEIYSIIIIFLIFSVCFFFFNEEVVKDSSENEKLRSGLSRNTVMRQEDSLFESGNFLDFSGSEESETLADSNGDITSTDDVAPTADGYSSLSSEEKERIRKEIIQKVKLLAERFPDNSLIPRELTEEKRKKDEEKMDKIRGILLEGGEVPKSEMEFYLDSKIKKTNDMTEILEYSMKFFKDSGRHYPDTFMKIIEDRLQSLRESKDELLNAKKNLESN
>NZ_CP012030.1|WP_002733458.1|325240_326041_+|hypothetical-protein
MKKVINQIGKALEYLDKLGTGKSFQLFRSLGYEKLYSLSEKVDHKTLLYISQHLDEKTIVEFLNRIPEETLVTLLSTVPPQNITYFANTIPMDDLILLSTSIPAADIAEMSFKTGKESAAELLKNIGTQKSIALLNEVGIQNFIELSLRIPPIQLIPIVQELTPEQSGIWIRKRGIGDIPKLIEAFGVQNLLVFLRTLGFKKNIHIIEVLGIEELIELAYTISGMKLPRLVSEKKQQTSPKKTFQKTKSKKKITTKQKSKSRMKRI
>NZ_CP012030.1|WP_002739540.1|324332_325244_+|hypothetical-protein
MGFWKRLFFPKKEYRSAAKAWIENPEKVQKSINRVLDTFFDSTLKELMPEKISLSLEPVAGLRIPEDKIKTILQGVNIRTVLPFNSVSEAMSQETQEAILEFAAGTITAPSKLFLMKVLGQSPIQEMFSLGLEKILVEFNRKLNPLAGMFQAAGFEKQISGFLTILLPSFTEKIAEMLHNSSESEAGKILISNTLKILFQTGFSDLGRLESTDLRKHLEKLRQTISSDPLLEKNMEKFYESFRDAVLNEYRGETLKEFLGYSDEEYIRFRDSVSKTTAENILVIHKQKPLTELVAGLLEDMLV
>NZ_CP012030.1|WP_002739780.1|323182_324313_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MQDAISKNSNITQIVYSTKTYDRLIGLVYKTRGILFDSIDEYFSENNRDRVLNAHYPTVIIGNHVEEGDILALSVIYKAVQPKIKFAIPAREDVLKKNFLIKEFRPKGTLKLIFGLIDKTNLIPVLLRYIGCFPVKRPFRDNARELLKSGELRGMVDQEWNILIERVTSGRNLFLFPEGTFNQDGYLNQIKRGVYFIRTKIKDVRFISFTLTYDYISAKKTQLHIAYGETFDIPENASSDEVTNIVKEKLGKNYVITSGNLLSMILMRLGTEASIGQEILFKRLQNFADEIKKKGKKIYVSGKLFGSHLEETFQNILNKGLENKFLKLDGNGEVFGTEKLLYKDTRNLRKKNEFLYHANQLTYHKPELDKILLSLT
>NZ_CP012030.1|WP_026054005.1|321993_323133_+|alanine-racemase
MKETASSWIEISKRSLSNNLNSFRSILRPGSTLTAILKSNAYGHGTDLMAKLCIEEGVSRIGVNSIEEAQSIRQIDPKIPILIMGEIQNPEKRKEALSDPNFWIIFSRPETARILSSLNPAPKLHLKIDTGMGRLGNHGETLKYTLGELKKNGITLDGICTHFASTEDVLEHKYSLMQIQKFEKAVLLAESLGYKNLIRHMCASASTMLFSSAHYEMVRVGISLYGLWPSIQTRLSLNLNGNKNFQLSPILSWKTRIVHIQNHPANSYIGYGSTFQTSYPTKVAIVPIGYYEGLDRKLSSNGDMLVLGKRARIIGRICMNMTMLDVTHIPGADVGSIVTVIGQDGEELITADDIADRTHTINYEITTRISESVCRIVVD
>NZ_CP012030.1|WP_026054004.1|321386_321875_-|DUF2505-family-protein
MKYKIVQQFPVPLKDLLKAREDRYKYLDKFPELKNVELLEERKNGNLVYQKRKVKLAESMPKVLATLLSDPSLLENSTFDLNTNTHEFTLAPPGNESIVQISGVSVYKELGPDKSERSYDVEVKSGVFLMGAAIEAVIEEVHKHSLEKDKNSISEFLNSYKS
>NZ_CP012030.1|WP_002725362.1|319951_320146_+|hypothetical-protein
MEFVKQKMSGESNLLKAYEIRLESESKIKQDVVKKYTNQSREKIPYFELVAKPKKKINYNHLSS
>NZ_CP012030.1|WP_002739591.1|333446_334583_-|OmpA-family-protein
MHGTNSSLNLDAAEIMARKANNYVTIKGRKYDRELIKLAEEFTSGKRNAKISINNAKQLLKAVKDNNSYTDIEKHTIEYIRENYKFTEKSDEWFRTEIRKWATEKVQETNNEGAGESIVVDEEEAPNENFPSSWGKDKNDGTSEIPAKDYTNYIPTPSAKPHLKRDKTVPILIFLIGLLVLTGLIYFFWTLFSSENKNRSNELGKTKINVAIVKGKEKSSSVSKMKKTVTEPNSEKLETVKGTIAKVEPKFSWFEKKHELSSNPKFREIESKVIHFEKNSIQIRKEARPGLNRLSRWMKEDSSIRVKIFGHTSLEGTEAANHRVSLLRAETVRDYLAGNGIAKDRFEVIPKGASVPIGDNSKEEGKEMNRRVELRIRN
>NZ_CP012030.1|WP_058331125.1|334643_335591_-|elongation-factor-P--(R)-beta-lysine-ligase
MNELSGEVLIKRAQCLSVLRKFFEKKNYLEMDTPCLKAVPSMEPYLDPFLVRSPSRKEKGYLITSPEYSLKEILSKGLEKIYEITHTFRSGEEGSPFHSAEFLMLEFYTVGISLEDLMDFCTELLEVLDCEFQAFGFDRNKVRKISVEESLRKYAHCGISKSELDRVILERGLSEIPAEKRAYEDSFFIVFLNLVETHLPKEFVFLYDYPPELAALSKIESGFAKRFELYYGSLELGNAFEELTDPVEQISRFCREQDLRKNLGKEVFSVDSGLERALREGIPDSCGISIGLDRLLLCILGGSSLREISPYYGKF
>NZ_CP012030.1|WP_002724906.1|335638_335974_+|hypothetical-protein
MNFVNPIQKYERFEIRRNRQSTEVIPLVVSFDEIAFEELKSVLALIFYQFNLHVKINLSRVKILPLPVAMKLLSFGFDLRLKSRTLVIEGASASFKKLIRFYRMDKAILVL
>NZ_CP012030.1|WP_002724923.1|335986_336394_-|DUF4279-domain-containing-protein
MSNPLSYPLTWVILSVNEDGLDSESVTRELDLNPDFSTPISATDKEGKPLGFGHWQLHSTLSAQAPLEDHILQILEKVAPYRRKVKEFAVKHPLCMYVSVEFSDSTRQETEIPARLLLLLGNLGIKLVFQPWKRD
>NZ_CP012030.1|WP_000849259.1|336621_337347_+|response-regulator-transcription-factor
MKTILVIEDDPDIGNLIRKSLDSAHYSTTLQTSGEEGLKFYKANHPDMVILDLSLPDIDGIEVCRTVRRNDENTPIFIVTARNEEIDRIMGLELGADDYITKPFSVRELKTRVDVFFRRWDKKAGIKPNVGASGEIIRGALKIDPVRRRVTLKDNIVNISRKEFDILQLMAASPGKVFSREMILEAVWGMEWDGFERMIDSHVKRIRSKLEKNSAQPEWIETIWGIGYRFTDNYDNIVIPD
>NZ_CP012030.1|WP_002739652.1|337916_338225_-|4a-hydroxytetrahydrobiopterin-dehydratase
MSDSDNADLKLFKQKLPSGWKIRFQRGVPFLSKVFSFQTYLAGVEFVHSLAHVAEKFDHHPDLFLSYRKVTVEIYTHSKDTITDLDLRFAKETEKIFKYREH
>NZ_CP012030.1|WP_002724931.1|338504_338918_-|hypothetical-protein
MNWISKLVRLKRRQKQRIFNKAYRQALKLMKKEFKAERERHLQAEKELEKYYRKDVDTEAKKTRKKIQELDNFKLLLERREMELDSKIVFLNEQLQKMEELKARMDGAVNLMARAGSLSNGAVDDAEKIKQTLKKVF
>NZ_CP012030.1|WP_002724940.1|339167_339446_+|DUF883-family-protein
MTSKTEDFNEEVESLKDKAKKITGKARGEYLEHVSDLKEKIKQISGDTSERAKQIIDQTGVYIKENPQKATLIGLGVGLGIGLLVGMLIRRK
>NZ_CP012030.1|WP_002724929.1|339463_339847_+|hypothetical-protein
MAKKRKSDSAKESYNDEYTKKGNDLKSHFLALVDSILEYFQTLLLYGQKLLTKRLQTGIQAYIFLKIGLFFFAFGSVGFLGALFVFLHKISGGDFLLSSLGTGGASFFLSILFLWLAASFLKIKDRS
>NZ_CP012030.1|WP_002724919.1|339843_340101_+|hypothetical-protein
MKEFPDLNPFDGSDRFLGKDPSDMSLEELKLYLHIQKLRVRLEFEKLQSSINYTGMVVDALDKLGMGKLLQSFLKTPDNVYQPEE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012030_1	1.1\|332935\|40\|NZ_CP012030\|CRISPRCasFinder	332935-332974	40	NZ_CP020413	Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence	262527-262566	2	0.95

1. spacer 1.1|332935|40|NZ_CP012030|CRISPRCasFinder matches to NZ_CP020413 (Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.95

tttgttggaaacggaggaaagaaaatcataaacttccttg	CRISPR spacer
tttattagaaacggaggaaagaaaatcataaacttccttg	Protospacer
***.**.*********************************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

147152 : 212494

Pseudomonas_phage(28.57%)

protease,tRNA,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002739637.1\|147152_149552_-\|protease	cysteine protease	NA	NA	NA	NA
WP_032853154.1\|149564_150023_-	hypothetical protein	NA	NA	NA	NA
WP_002739740.1\|150196_150835_-	energy transducer TonB	NA	NA	NA	NA
WP_002722169.1\|150853_151258_-	biopolymer transporter ExbD	NA	NA	NA	NA
WP_002732150.1\|151280_151895_-	MotA/TolQ/ExbB proton channel family protein	NA	NA	NA	NA
WP_002732199.1\|152470_155071_-	TonB-dependent receptor plug domain-containing protein	NA	NA	NA	NA
WP_002722240.1\|155081_155489_-	hypothetical protein	NA	NA	NA	NA
WP_002731434.1\|155490_156027_-	hypothetical protein	NA	NA	NA	NA
WP_002722203.1\|155998_156376_-	hypothetical protein	NA	NA	NA	NA
WP_002722187.1\|157039_158092_-	methylmalonyl Co-A mutase-associated GTPase MeaB	NA	NA	NA	NA
WP_002722217.1\|160293_162174_-	methylmalonyl-CoA mutase small subunit	NA	NA	NA	NA
WP_002760183.1\|162264_163254_-	TerC family protein	K7QKE8	Escherichia_phage	8.2e-37	35.2
WP_002739698.1\|163344_163971_+	lysoplasmalogenase	NA	NA	NA	NA
WP_002739727.1\|164033_164933_+	ferritin family protein	NA	NA	NA	NA
WP_002739528.1\|164932_166090_+	aminotransferase class V-fold PLP-dependent enzyme	A0A2K9L2Y3	Tupanvirus	1.1e-24	26.1
WP_002736626.1\|166615_167560_+	bile acid:sodium symporter family protein	NA	NA	NA	NA
WP_002722197.1\|169587_169752_+	50S ribosomal protein L33	NA	NA	NA	NA
WP_002722265.1\|169769_170228_+	TraR/DksA family transcriptional regulator	NA	NA	NA	NA
WP_016757935.1\|170335_172435_+	hypothetical protein	NA	NA	NA	NA
WP_002739619.1\|172417_173809_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_002738164.1\|173852_175784_-	LruC domain-containing protein	NA	NA	NA	NA
WP_002731433.1\|175932_176667_-	ubiquinone/menaquinone biosynthesis methyltransferase	NA	NA	NA	NA
WP_002739536.1\|176801_177110_-	hypothetical protein	NA	NA	NA	NA
WP_002721075.1\|177066_177582_+	MotA/TolQ/ExbB proton channel family protein	NA	NA	NA	NA
WP_002739658.1\|177595_178009_+	biopolymer transporter ExbD	NA	NA	NA	NA
WP_002721082.1\|178009_178354_-	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_002721084.1\|178350_179421_-	DUF1574 domain-containing protein	NA	NA	NA	NA
WP_002739634.1\|179430_180828_-	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	3.2e-63	36.4
WP_002721094.1\|180824_181985_-	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_002721086.1\|181998_183414_-	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	1.9e-58	34.9
WP_002732102.1\|183485_184868_-	hypothetical protein	NA	NA	NA	NA
WP_002721114.1\|185088_185691_-	hypothetical protein	NA	NA	NA	NA
WP_002721072.1\|185695_186838_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_002721101.1\|186812_188411_-	DUF2029 domain-containing protein	NA	NA	NA	NA
WP_002739711.1\|188415_189459_+\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_081396849.1\|189865_190450_+	AAA family ATPase	NA	NA	NA	NA
WP_044094689.1\|190437_191178_+	hypothetical protein	NA	NA	NA	NA
WP_002743025.1\|191456_192839_+	hypothetical protein	NA	NA	NA	NA
WP_016749207.1\|192959_193265_+	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_002739758.1\|193937_194678_+	hypothetical protein	NA	NA	NA	NA
WP_032854461.1\|194689_195424_-	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
WP_002739487.1\|195704_196295_+	hypothetical protein	NA	NA	NA	NA
WP_002726039.1\|196308_197001_+	heme-binding protein HmuY	NA	NA	NA	NA
WP_002726021.1\|197005_199099_+	TonB-dependent receptor	NA	NA	NA	NA
WP_002739774.1\|199502_200699_-	MFS transporter	NA	NA	NA	NA
WP_002732111.1\|200700_201378_-	biliverdin-producing heme oxygenase	M4QDD1	Prochlorococcus_phage	3.4e-42	43.8
WP_002726041.1\|201888_203463_+	hypothetical protein	NA	NA	NA	NA
WP_002739563.1\|203462_204707_+	hypothetical protein	NA	NA	NA	NA
WP_002724411.1\|205365_205713_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_144429907.1\|205818_206163_+\|transposase	transposase	NA	NA	NA	NA
WP_002739754.1\|207736_209320_-	PDZ domain-containing protein	NA	NA	NA	NA
WP_026054025.1\|209334_210843_-\|protease	serine protease	A0A1V0CPG8	Kaumoebavirus	3.1e-19	24.3
WP_002726057.1\|210873_211407_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	3.4e-29	44.5
WP_002726085.1\|211606_212494_-\|protease	protease HtpX	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP012029

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012029_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012029_1

412488-412698

Orphan

I-E,II-B

Consensus_repeat	Method
CCGGTTCAACCCCACGCATGTGGGGAAAAG	PILER-CR
CCGGTTCAACCCCACGCATGTGGGGAAAAGN	CRT
CGGTTCAACCCCACGCATGTGGGGAAAAG	CRISPRCasFinder

3 spacers

csa3

The CRISPR arrays of NZ_CP012029_1

>merge|NZ_CP012029|1|412488-412698|PILER-CR,CRT,CRISPRCasFinder
CCGGTTCAACCCCACGCATGTGGGGAAAAGTTCGAGAGAGCAGGGATTTCTATTGCCAGTGTCGGTTCAACCCACGCATGTGGGGAAAAGACCATACTCTAACAGGAGCTCCAGGAAGGAACCGGTTCAACCCCACGCATGTGGGGAAAAGTAATCCTGAATGTAAAAGGCGCCCTGTTCCCCGGTTCAACCCCACGCATGTGGGGAAAAG

>NZ_CP012029|1|1|412488-412698|PILER-CR
CCGGTTCAACCCCACGCATGTGGGGAAAAG	TTCGAGAGAGCAGGGATTTCTATTGCCAGTGTCGGTTCAA
CCCACGCATGTGGGGAAAAGACCATACTCT	AACAGGAGCTCCAGGAAGGAACCGGTTCAAC
CCCACGCATGTGGGGAAAAGTAATCCTGAA	TGTAAAAGGCGCCCTGTTCCCCGGTTCAAC
CCCACGCATGTGGGGAAAAG

>NZ_CP012029|1|1|412488-412698|CRT
CCGGTTCAACCCCACGCATGTGGGGAAAAG	TTCGAGAGAGCAGGGATTTCTATTGCCAGTG
TCGGTTCAACCCACGCATGTGGGGAAAAGA	CCATACTCTAACAGGAGCTCCAGGAAGGAA
CCGGTTCAACCCCACGCATGTGGGGAAAAG	TAATCCTGAATGTAAAAGGCGCCCTGTTCC
CCGGTTCAACCCCACGCATGTGGGGAAAAG

>NZ_CP012029|1|1|412489-412698|CRISPRCasFinder
CGGTTCAACCCCACGCATGTGGGGAAAAG	TTCGAGAGAGCAGGGATTTCTATTGCCAGTG
TCGGTTCAACCCACGCATGTGGGGAAAAG	ACCATACTCTAACAGGAGCTCCAGGAAGGAAC
CGGTTCAACCCCACGCATGTGGGGAAAAG	TAATCCTGAATGTAAAAGGCGCCCTGTTCCC
CGGTTCAACCCCACGCATGTGGGGAAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012029.1\|WP_002725220.1\|408424_408763_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP012029.1\|WP_002738631.1\|407520_408336_+\|sterol-desaturase-family-protein	unknown	unknown	gnl\|CDD\|377224
NZ_CP012029.1\|WP_002738515.1\|417047_417905_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NZ_CP012029.1\|WP_002721488.1\|423818_424754_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_002738435.1\|418056_418938_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_002730604.1\|428379_429729_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|172808
NZ_CP012029.1\|WP_002738554.1\|427062_427707_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_002738700.1\|399478_401503_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NZ_CP012029.1\|WP_002738417.1\|408814_409222_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176910
NZ_CP012029.1\|WP_002733108.1\|413385_414132_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_002725292.1\|406444_407224_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|187576
NZ_CP012029.1\|WP_002738618.1\|425210_426296_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369473
NZ_CP012029.1\|WP_002733073.1\|405142_406444_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|176464
NZ_CP012029.1\|WP_032854406.1\|419401_421222_+\|translational-GTPase-TypA	unknown	unknown	gnl\|CDD\|224138
NZ_CP012029.1\|WP_016748918.1\|427703_428297_-\|DnaJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|223560
NZ_CP012029.1\|WP_032853145.1\|415106_416321_+\|tetracycline-resistance-MFS-efflux-pump	unknown	unknown	gnl\|CDD\|340946
NZ_CP012029.1\|WP_050547985.1\|398597_399473_+\|carboxylating-nicotinate-nucleotide-diphosphorylase	unknown	unknown	gnl\|CDD\|238806
NZ_CP012029.1\|WP_002738477.1\|401516_403319_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173862
NZ_CP012029.1\|WP_002725236.1\|410926_411133_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_002738613.1\|403329_404397_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP012029.1\|WP_002738631.1\|407520_408336_+\|sterol-desaturase-family-protein	gnl\|CDD\|377224	pfam04116, FA_hydroxylase, Fatty acid hydroxylase superfamily. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.	9.9013e-28
NZ_CP012029.1\|WP_002738700.1\|399478_401503_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NZ_CP012029.1\|WP_002738417.1\|408814_409222_+\|hypothetical-protein	gnl\|CDD\|176910	cd08901, SRPBCC_CalC_Aha1-like_8, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	2.21914e-32
NZ_CP012029.1\|WP_002725220.1\|408424_408763_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.05572e-12
NZ_CP012029.1\|WP_002725292.1\|406444_407224_+\|hypothetical-protein	gnl\|CDD\|187576	cd05266, SDR_a4, atypical (a) SDRs, subgroup 4. Atypical SDRs in this subgroup are poorly defined, one member is identified as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is related to, but is different from, the archetypical SDRs, GXGXXG. This subgroup also lacks most of the characteristic active site residues of the SDRs; however, the upstream Ser is present at the usual place, and some potential catalytic residues are present in place of the usual YXXXK active site motif. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.1103e-14
NZ_CP012029.1\|WP_002738477.1\|401516_403319_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173862	cd08497, PBP2_NikA_DppA_OppA_like_14, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	5.42523e-175
NZ_CP012029.1\|WP_002738618.1\|425210_426296_+\|hypothetical-protein	gnl\|CDD\|369473	pfam07705, CARDB, CARDB. Cell adhesion related domain found in bacteria.	0.00351612
NZ_CP012029.1\|WP_002733073.1\|405142_406444_+\|adenylosuccinate-lyase	gnl\|CDD\|176464	cd01360, Adenylsuccinate_lyase_1, Adenylsuccinate lyase (ASL)_subgroup 1. This subgroup contains bacterial and archeal proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP).	0
NZ_CP012029.1\|WP_032854406.1\|419401_421222_+\|translational-GTPase-TypA	gnl\|CDD\|224138	COG1217, TypA, Predicted membrane GTPase involved in stress response [Signal transduction mechanisms].	0
NZ_CP012029.1\|WP_016748918.1\|427703_428297_-\|DnaJ-domain-containing-protein	gnl\|CDD\|223560	COG0484, DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones].	1.15683e-08
NZ_CP012029.1\|WP_032853145.1\|415106_416321_+\|tetracycline-resistance-MFS-efflux-pump	gnl\|CDD\|340946	cd17388, MFS_TetA, Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.74374e-168
NZ_CP012029.1\|WP_050547985.1\|398597_399473_+\|carboxylating-nicotinate-nucleotide-diphosphorylase	gnl\|CDD\|238806	cd01572, QPRTase, Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide. QPRTase functions as a homodimer with two active sites, each formed by the C-terminal region of one subunit and the N-terminal region of the other.	1.04071e-114
NZ_CP012029.1\|WP_002738515.1\|417047_417905_+\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	3.31792e-70
NZ_CP012029.1\|WP_002730604.1\|428379_429729_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|172808	PRK14332, PRK14332, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0

>NZ_CP012029.1|WP_002725236.1|410926_411133_+|hypothetical-protein
MFLRQLRAGLKTSKMWELPRKLDNNKTYSKADDRQRGENFSFYEKFKMNISVEVLRPALRTRIKTLGM
>NZ_CP012029.1|WP_002738417.1|408814_409222_+|hypothetical-protein
MNLRFTVQTKIQKPLEAVFQAVYDPKHLSGYFTTGGASGPLVEGTKVIWKFADFPSMKGENEGVVVNVVEVVPDSKIVLEWDAHEGSYEGENELLTVGGYKTKTEMIFESLDPNNTLVKITESGWKVSQSALDGS
>NZ_CP012029.1|WP_002725220.1|408424_408763_-|winged-helix-turn-helix-transcriptional-regulator
MYKLDKQDLIFKALADSKRREILDLLRKKPKTTGEICSYFEPLDRCTVIQHLKILENAGLLIVKRKGRVRWNYLDNVPIQEIYDRWISKYAKPTLERLAVFKKQMDRDNRTK
>NZ_CP012029.1|WP_002738631.1|407520_408336_+|sterol-desaturase-family-protein
MGELLSRFGYSGFFGIIWGIFLIRYLVFSGIAFLVVWVFCGKKLSHKLIQSKKPEKEKIFYEIKYSMLTFFIFGLSGIFVVWAKVNGFNRIYNNVGDYGIVYLIFSSFVLVLLHDTYFYWTHRMMYHKLFFKYFHLVHHKSINPSPWAAFSFHPLEAIVESGIVPLVSFVLPLHPGAMIVFFVYMTSLNVLGHLSYEFFPSWFLKSRFTSWHNTTTHHNMHHKYFNCNYSLYFNFWDRIMGTNHEKYKEKFEEVASRVPEKAKLILGKYNI
>NZ_CP012029.1|WP_002725292.1|406444_407224_+|hypothetical-protein
MRVGIFGLGYTGIRIAKRLKLQAEVRLETFSAKTRVEGTEVFDFSNPFALKEFGEKFSREDFDLCVVTFPVQKLFDPISFINLLFSVGKRCILLGTTSIYKRVPDIVESTPLIEDHDRFAIENEWIGRSGKILRLCGIYGPLRNPGDWARKGLVKKCSKQLNLIHGDDVALTISLLIRKIRTTGWDTLPNVLNLSDNQWHTWKEIFSFLEEHEKISKTQVEESPKEDSFVDSGLIRSLLPDLQTKNFWMELEGLEGIGD
>NZ_CP012029.1|WP_002733073.1|405142_406444_+|adenylosuccinate-lyase
MIDRYSNPEISKIWELENKFEIWKEIEILACEIRMKRGEIPPEEFQEIKTMAKFNVGEILEIESKVHHDVIAFLTNMNSYIGPAGRHVHYGLTSSDIGDTALCVQMVQAMDLILKKTDALISVVKEKAIQYRDLPCIGRSHGIHAEPMTLGLKFALFFEELNRNRKRMSEARNEIAVGKLSGAVGTYSNVDPEIEAYVCEKMGLKVDPISTQVVSRDRHAFYLSVLGVTASSLDRMATEIRLLQKTEGREVEEPFSAGQKGSSAMPHKRNPVICERISGLSRVIRANVNVGLQDVALWHERDISHSSAERVVLPDSTIALEYILDKMLFVVKNLHVYPDAIERTLGVTRGLIFSQKVLLALIERGKIAREEAYLIVQEHAMAVWANPSETLKTRLENDNRVSQVLTRKDLEDIFKIEPYLEKVGLIYRRLGLE
>NZ_CP012029.1|WP_002738613.1|403329_404397_+|hypothetical-protein
MNKRNRFEELGGVIRDFLSSPKIPNFIEFLEKGLDKELFYDPEKTKPEIPIEDLPVDYRLRESGFARKTYERLFPVSHLFRIMHRYEREYLDNFMPLSTGKYIGRGSYKFVYALPWNQVVKVGKSKLPSDPIFGSLYKHVQKNLDRYLKSEEIQLMEFLESKAWARSSKENIRFKFARLGLERLHYWKLKSLIPDLVLPTRYFMGLRARTTPFGVPIFTLTPCDNQNLLPGKHLKEFIRLNEKIRQNPLQDAFFPKWKLNFDTHKFGVVSRSRLKKIALDFHRVIEVTKHLAEEEKLIFDIHSENIIITFPDFSLKIFDYHVFDEHLYEPSKENPSPEIDHINTIREFVRSFELG
>NZ_CP012029.1|WP_002738477.1|401516_403319_+|ABC-transporter-substrate-binding-protein
MKRYSIFCMFFVLSVFTFLACGDKEEFETSAVVETLPWNGNPNSIPVALRGQNPIVSPHAKKGGTFRIYSHQFPKSLNYYLDQFSTTAHIFSLMFEPLLDYHPITLEPIPHLASSWRVSPDKKKFTFTIDANAVWSDGKPVTANDVLFTYETLMNKNNNTAVFRIDLSRFEKPVVLSEREIEFTQKEIHWSNFNTIANSLYILPAHYYKDRNFDKENFDFPVVSGPYSMLSAKKGRYIKMRRRGDYWMRAYPFYKGLDNFDTILFKVYNEESIAFQAFKKGDIDIYPTYTASFWVKDAIGEKFDENYILKQKIYNSKPIGFQGLVFNMRREIFSDVKVRKAFAHLVDRKLLIEKLAYNEYEETNAFYQDLWPANSFPNPPLEFDVTKARELLAKAGWKINSKGILEKDGKEFRFSILERDKKSEKYLTLIQERAKEVGIIINLESTDLAEWSSRMDKYDFDMTWAAWGGGVFKDPEAMWYSKYAEEKGQPNLSGFKNVAVDKLIDQQRTEFNVTKRNEILKKIDKILTAEVPYVLLWNTSATRVMYWNRFRAPKNPLGKFGSEREASSLWWFDEEQSSKLNDAILKKEKLSPVPGKVYFQ
>NZ_CP012029.1|WP_002738700.1|399478_401503_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MGFVKTPATKDMLLEGVRETLGESAYESVQKAYDVSERAHQGQFRLSGEPYIVHPLQVGFILYELGLDEKVICAGLLHDVIEDTQYSRDDMIRDFGEDITDLVEGVTKISKIKSQSKETEAAENIRKIIVATIKDIRVILIKLADKTHNMRTLSFQLPEKQKRIAQETLSLYAPIAGRLGIYKIKSELEDLAFQVLNPEEYQEVKKNINSKKSEREGFIETLKIILLQRLSEIQIEADVDGRAKHFYSIYRKMKLKEKTFNEIFDLRAIRIITNEVKDCYGVLGIVHTLWNPVPGRFKDYIATPKTNMYQSLHTTVIGPDGKPLEVQIRTRDMNDIAEYGIAAHWMYKEGKPSLSEKNVKVRWLELLSSWQDSALDPKEFVEELKYDLHEDEVFVFTPKGEILQLPKGATILDFAFRIHTDVGLKAKGGRINGRMLPLRTELRSGDQIEIITDKRTKPSPIWLRIVRTPSARQKLRSYFRKLKEENKKDLQQEAEFAAEITLNVEVLEEFKKKPLAKPAKQIDLGAGKVIVAGLRGIPERLSGCCSPLPGDGIIGFVTRGRGVSIHKKGCATAKQQEQEESMRIITVEWDYGQSESIPVLIEVKSKDRQGIFMEIVKSISNTQTNIRESKASTDQRGNLVANFEVDVEHLDQLKEILSNLKQIPDVYQAHRIKN
>NZ_CP012029.1|WP_050547985.1|398597_399473_+|carboxylating-nicotinate-nucleotide-diphosphorylase
MKRAYTDPVSSVSYQDYETLVKLAWEEDCPEEDITSVSLFTPDQKATASLNARESGILCGIGALEVLNVLSENQIHSELLKQDAESFQKGDTLLRIQGNLVQILRIERILLNFLQYLSGISTRTGEVVQKYGRKGLMIFDTRKTLPGYRKLAKYAVYCGGGNNHRLNLSEMAMIKDNHLAMYSSSREPVEKIKARFPGKIVEVEIDSLLQLEEAIGSGAEVILLDNFSLEDMKTAYSILKQKAPNVQIEFSGGITPEKLEVLSEFSGAGVSMGYLTHTTRFLDLGLDIEQH
>NZ_CP012029.1|WP_002733108.1|413385_414132_-|hypothetical-protein
MKMIQKIFRKEKKKKQNKFKISKFFGGYCVLLLLFFFNCLPDQQSHEDNLLLSLLSLPNDQSLELQQDRSMRKAKPRPRPKRKYDGVTFVSYATGKRIQANSKAPKGWLKVDASRDTYFTRFNLYQDGSDPNCIESGRIRVETSANPKYYWNWWAGGGGGNYAYYPKYNDGSNRLSILVMSGGCLESGGKVAFADHDTLGYGYDYYITNWKGGSWNEYLFLWVRTLNPGPREIFTAILSPTPPEAAAE
>NZ_CP012029.1|WP_032853145.1|415106_416321_+|tetracycline-resistance-MFS-efflux-pump
MNPQRPAALGFIFVTVLIDVIGFGIIVPVLPKLIQELTHGSLSDVAWYGGLLMFAYSFVQFISAPFVGGLSDRYGRRPILLASLFGFTLDYLFLAFAPSIFWLFVGRVVSGIMGASFTTGYAYIADISPPEKRAQNFGILGAAFGLGFIIGPVIGGSLGQFGSRAPFLAAAALTLVNWLFGFFVLPESLTDENRRKFEWKKANPIGSLINLKRYPMIIGLIVAFFLINTAAHAVQGTWNYYTMEKFQWNEAMIGYSLGVVGLVYAVTQGGLIRIILPVLGQNRSIYLGLALSALGYALFALATQSWMMFVFLIPYCLGGIAMPPLQGIMSSQVPPREQGELQGALTSLMSVTAIVGPILMTGLFSYFTARETPIYSPEAPLWMGTILTAASLWISVGSLRKHHS
>NZ_CP012029.1|WP_002738515.1|417047_417905_+|pirin-family-protein
MKIISAVIKELGDNFRVRRILPSIEARHVGPFVFVDHMGPVPIQTGKELTVRSHPHIGLATITYLYDGVILHRDSIGSEMPIRPYEVNWMTAGSGIAHSERSQLDSQYSILEGIQTWVALPKESEEVSAEFFHLDQKDIPVIEGESWELRLIAGEFLGKRSPVKVYSSLFYADLDVEPGAKGEWNIPGDQESALYVARGSLEIRDQKIQVGQMAVFNSGETISFSSTQGGRSILLGGIPFPERRYLWWNFVSTSPERIEKAKLEWKEERFPKVPGETERIPLPEG
>NZ_CP012029.1|WP_002738435.1|418056_418938_-|hypothetical-protein
MLHFIFYFLILISLIACNESKNKINSDLLLLLAISTPDRAENYDRDVQIITNLSTFTDSGKVEITCDLNYSSQQDIDYYVEQLKKEIARYPRGYWIKTGVDKIVLCKSMTTADGRIKLAFSDINLLAISVTQPMATMRYGTTTCGGIPNFNSFECYDQPAIHHELTHSVDRSLTPAINFLLYFDPEWEKLNAPGFQYYGSENFLQIPVVWHPLPGIMGRYGASHFVEDRAVFGALIMGWPATYNILVQACQTDPFVAAKVRLTVSRWKQFWPFPGAENTEWKIRMAQAERDCD
>NZ_CP012029.1|WP_032854406.1|419401_421222_+|translational-GTPase-TypA
MEIRNIAIIAHVDHGKTTLLDGILRQTGAVTAKEDGERIMDSNDLEKEKGITIKAKNTAVVYKGTRINVVDTPGHADFGGEVERVLATADSCLLLVDAFDGPMPQTRFVLGKSLQLGHKPILVINKIDRPGARPEAVVDMAFDLFSDLGATDEQLDFPIVYASAKQGWAVYNLSDSPGTNLDPLLDTVLKHVPPVQADTEAPLQFQVTSLDYNDYVGRIAVGKIYAGKMALGMNVIQLAAKKSDTTTPTDTALFRITKLYNFEGLKRNEVNNAEAGDIVAIAGLPDVFIGDTICEPGKPAPRPAIEVEEPTVSMFFMVNNSPFAGKEGKFVTTRNIRERLDRELETNVAMKLEETEDKDRFKVLGRGELHLSVLIETMRREGFEIQVSRPEVILKTNEQGQKLEPYEYLVMDIPDQFTGTIIAELNRRKGELQLMDAHPSGMTRVEFVIPTRGIIGFRGFFISETRGEGVMSSRFLRFDIYKGEIPGRKNGALISMDSGETTAYALWKIQERGELVIGPNTAVYPGMIIGIHSRENDLEVNPVKEKKLSNVRSSGADEAIRLVPPRKFSLEQNIEFLDDDELLEVTPANLRLRKKFLDATMRKRNK
>NZ_CP012029.1|WP_002721488.1|423818_424754_-|hypothetical-protein
MRIKIEYIIILLYIILFIGCGKNLRGKPTPPNPDLAGFYLSSETAEWTKDGKMKIEVLSIFPKSNGDLSFERKTIVRLSFITSDNREEWRIRTGGVVTSENEILLQESLYQEFHQPHMGTRESDPKRWKLSEMGAASKVREVGNVTLSGNLLGEISPDNKTLRFSKMTFTKIGGSFQGRITTHVNQKSVTIDNETAGVVFYKAAVNTAEQIVSVFSKSELIKPGMIFLVGKDQVPCKIVEIHQHSGILEPVENGKILSVSVGDPVILKGDIDTKAINKRATADELIRKLKSDPNVSKEELIREIEKLKNVR
>NZ_CP012029.1|WP_002738618.1|425210_426296_+|hypothetical-protein
MKEFLRKIITGMSVILIFYVTWNCGGEKQVDPSSLLMLLNSEQFSGTSAYSFEVMDLQNTDVNQVGPEFEISESDNSSKPDLMVYVYFGGSRQVKPGEDISRKISLQVANFGSVLAVGNRSGSEGYMIDLILSKDKVVPEGYASYTFDFQEDVLLGGGRISNTPNLVPGALVSVSEGSNIIPKNVPSGDYFVCARVDVGSKVSESDENNNTNCFPISIGFEEPLPDLIIPRASIYPSGMKCKAHKPMMYITAEIKNIGQGASPAMPDVGLINALDPSGIYGNGTGISMIQPGETVTVTFPIYFPINASSDIDISLVEKTHTLDLRLNRGSWIPESNVQNNGYTRKPLELTIPEGYCKNHSR
>NZ_CP012029.1|WP_002738554.1|427062_427707_-|hypothetical-protein
MKTITKKNDPKHLAEDEISYYYSLLQEELTEFDCGELCKPDNDGIPFCCIADNAVPTLYRSEFSMLQKRTDLWKVWSPETETDKKMLSEYDSKETLFCECKGIQFCERENRSISCRTFPLEPYLDTRGVLVGLVFMKEFTGKCPLTLRAKDIRQEFIDSHFIFWEKLLFSLNTEYEIFWNSSKSYRRSRAKTGKKFPIFFPSHLQGKEYLEQYL
>NZ_CP012029.1|WP_016748918.1|427703_428297_-|DnaJ-domain-containing-protein
MAVNTKPDYYKLLNVSRSSNLATIESAYRNYLEKLDSDPWNPSRELDREEGTRAYLTLSSPESREEYDKTLNYEFLLLDTTKIPEEFESFYNVQKLSEGEETREFYSRFLEFKKDLENTLKNLRITVLFFLSAFSLLTIFALLMALAQKNGFLSSGVELFYRKWGMLCSTGILFSGYTIFRKILNSKKNKIGQNRNH
>NZ_CP012029.1|WP_002730604.1|428379_429729_+|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MGVLEREKKTGKVYIETYGCQMNEYDSGIVSSLMKDAEYSSSPDPENSDIIFLNTCAIRENAHAKIYNRLQSLGYLKKRNPELVIGVLGCMAQNLGDDLFHQELPLDLVVGPDNYRSLPELIQRIRSGEHSISLTRLSKIETYDEIEPRVVNGIQAFVTIMRGCNNFCTFCVVPYTRGRERSRDPKSIVREIQDLTEKGIRQITLLGQNVNSYKEQGTDFAGLIQMLLDETTIERIRFTSPHPKDFPVRLLRLMAQNPRFCPNIHLPLQAGNTRVLEEMKRSYSKEEFLDVVREIRNIVPDVGITTDIIVGFPNETEEEFEDTLAVVREVQFDMAFMFKYSEREGTMARKKLPDNVPEETKSARLTKLVDLQTSISHEQNRARIGRVYSILIENTSRKSEKQLCGRTPCGRMTVFPLPEGRSASEMIGSTVSVRIESATSATLKGGILS

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Crispr_ID: NZ_CP012029_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012029_2

703831-703920

Orphan

Consensus_repeat	Method
AAAGAGTCGTCGCTTCGCTTTGAGTAATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012029_2

>merge|NZ_CP012029|2|703831-703920|CRISPRCasFinder
AAAGAGTCGTCGCTTCGCTTTGAGTAATTTGTTTCGATGTAATCGAATTTCTTTGCTTTGCAAAGAGTCGTCGCTTCGCTTTGACTAATT

>NZ_CP012029|2|2|703831-703920|CRISPRCasFinder
AAAGAGTCGTCGCTTCGCTTTGAGTAATT	TGTTTCGATGTAATCGAATTTCTTTGCTTTGC
AAAGAGTCGTCGCTTCGCTTTGACTAATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012029.1\|WP_002730763.1\|709214_709607_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_002740353.1\|694726_697420_-\|DUF1554-domain-containing-protein	unknown	unknown	gnl\|CDD\|369437
NZ_CP012029.1\|WP_002740315.1\|694328_694625_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176868
NZ_CP012029.1\|WP_002740493.1\|703940_705377_-\|adenylate/guanylate-cyclase-catalytic-domain-protein	unknown	unknown	gnl\|CDD\|143636
NZ_CP012029.1\|WP_002740412.1\|698443_699112_-\|SIMPL-domain-containing-protein	unknown	unknown	gnl\|CDD\|377344
NZ_CP012029.1\|WP_002730926.1\|709620_710268_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369616
NZ_CP012029.1\|WP_002619721.1\|700984_701275_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NZ_CP012029.1\|WP_002732825.1\|692705_692924_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_002730732.1\|713593_714562_-\|FliG-protein	unknown	unknown	gnl\|CDD\|224453
NZ_CP012029.1\|WP_032853361.1\|706227_708489_-\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP012029.1\|WP_002732834.1\|692209_692707_-\|DUF1579-family-protein	unknown	unknown	gnl\|CDD\|377882
NZ_CP012029.1\|WP_016757377.1\|690515_691751_-\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|316093
NZ_CP012029.1\|WP_032853362.1\|701696_701897_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_002730932.1\|699330_700971_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP012029.1\|WP_058331075.1\|716769_717249_+\|DUF1564-domain-containing-protein	unknown	unknown	gnl\|CDD\|284922
NZ_CP012029.1\|WP_002730920.1\|710996_712361_-\|flagellar-protein-export-ATPase-FliI	unknown	unknown	gnl\|CDD\|274608
NZ_CP012029.1\|WP_058331074.1\|714561_716265_-\|flagellar-basal-body-M-ring-protein-FliF	unknown	unknown	gnl\|CDD\|235668
NZ_CP012029.1\|WP_002730765.1\|710426_710993_-\|flagellar-export-protein-FliJ	unknown	unknown	gnl\|CDD\|131526
NZ_CP012029.1\|WP_002740555.1\|701895_703416_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|129679
NZ_CP012029.1\|WP_002730816.1\|712666_713590_-\|flagellar-assembly-protein-FliH	unknown	unknown	gnl\|CDD\|235850

Protein	Function_ID	Function_description	E-value
NZ_CP012029.1\|WP_002740353.1\|694726_697420_-\|DUF1554-domain-containing-protein	gnl\|CDD\|369437	pfam07588, DUF1554, Protein of unknown function (DUF1554). A family of proteins identified in Leptospira interrogans.	1.90756e-45
NZ_CP012029.1\|WP_002740493.1\|703940_705377_-\|adenylate/guanylate-cyclase-catalytic-domain-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	7.92362e-65
NZ_CP012029.1\|WP_002740412.1\|698443_699112_-\|SIMPL-domain-containing-protein	gnl\|CDD\|377344	pfam04402, SIMPL, Protein of unknown function (DUF541). Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	9.79988e-30
NZ_CP012029.1\|WP_002730926.1\|709620_710268_-\|hypothetical-protein	gnl\|CDD\|369616	pfam07956, DUF1690, Protein of Unknown function (DUF1690). Family of uncharacterized fungal proteins.	0.000972309
NZ_CP012029.1\|WP_002619721.1\|700984_701275_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	2.6333e-42
NZ_CP012029.1\|WP_002740315.1\|694328_694625_+\|hypothetical-protein	gnl\|CDD\|176868	cd07826, SRPBCC_CalC_Aha1-like_9, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	1.43154e-12
NZ_CP012029.1\|WP_002730732.1\|713593_714562_-\|FliG-protein	gnl\|CDD\|224453	COG1536, FliG, Flagellar motor switch protein [Cell motility and secretion].	8.4802e-27
NZ_CP012029.1\|WP_032853361.1\|706227_708489_-\|TonB-dependent-siderophore-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	4.89065e-63
NZ_CP012029.1\|WP_002732834.1\|692209_692707_-\|DUF1579-family-protein	gnl\|CDD\|377882	pfam07617, DUF1579, Protein of unknown function (DUF1579). A family of paralogous hypothetical proteins identified in Rhodopirellula baltica that also has members in Gloeobacter violaceus, Sinorhizobium meliloti and Agrobacterium tumefaciens.	2.33534e-29
NZ_CP012029.1\|WP_016757377.1\|690515_691751_-\|ATP-grasp-domain-containing-protein	gnl\|CDD\|316093	pfam13535, ATP-grasp_4, ATP-grasp domain. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.	1.8268e-15
NZ_CP012029.1\|WP_002730932.1\|699330_700971_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP012029.1\|WP_058331075.1\|716769_717249_+\|DUF1564-domain-containing-protein	gnl\|CDD\|284922	pfam07600, DUF1564, Protein of unknown function (DUF1564). A family of paralogous proteins in Leptospira interrogans. Several have been annotated as possible CopG-like transcriptional regulators (see pfam01402).	7.8746e-82
NZ_CP012029.1\|WP_002730920.1\|710996_712361_-\|flagellar-protein-export-ATPase-FliI	gnl\|CDD\|274608	TIGR03497, FliI_clade2, flagellar protein export ATPase FliI. Members of this protein family are the FliI protein of bacterial flagellum systems. This protein acts to drive protein export for flagellar biosynthesis. The most closely related family is the YscN family of bacterial type III secretion systems. This model represents one (of three) segment of the FliI family tree. These have been modeled separately in order to exclude the type III secretion ATPases more effectively. [Cellular processes, Chemotaxis and motility].	0
NZ_CP012029.1\|WP_058331074.1\|714561_716265_-\|flagellar-basal-body-M-ring-protein-FliF	gnl\|CDD\|235668	PRK06007, fliF, flagellar basal body M-ring protein FliF.	1.81735e-137
NZ_CP012029.1\|WP_002730765.1\|710426_710993_-\|flagellar-export-protein-FliJ	gnl\|CDD\|131526	TIGR02473, conserved_hypothetical_protein, flagellar export protein FliJ. Members of this family are the FliJ protein found, in nearly every case, in the midst of other flagellar biosynthesis genes in bacgterial genomes. Typically the fliJ gene is found adjacent to the gene for the flagellum-specific ATPase FliI. Sequence scoring in the gray zone between trusted and noise cutoffs include both probable FliJ proteins and components of bacterial type III secretion systems.	1.57242e-10
NZ_CP012029.1\|WP_002740555.1\|701895_703416_+\|hypothetical-protein	gnl\|CDD\|129679	TIGR00591, Deoxyribodipyrimidine_photo-lyase, photolyase PhrII. All proteins in this family for which functions are known are DNA-photolyases used for the direct repair of UV irradiation induced DNA damage. Some repair 6-4 photoproducts while others repair cyclobutane pyrimidine dimers. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	4.3351e-60
NZ_CP012029.1\|WP_002730816.1\|712666_713590_-\|flagellar-assembly-protein-FliH	gnl\|CDD\|235850	PRK06669, fliH, flagellar assembly protein H; Validated.	5.17791e-65

>NZ_CP012029.1|WP_002740555.1|701895_703416_+|hypothetical-protein
MFRKENLVRVRELGQNPILEEKPYVLYWMSMARRLAWNHSLDYSIHLSQKYKKELLIYEPLKMDYPWSSPRLHKFILDGMSYNARDAKKNGLYYAAFVETPNNPIADVFEKLTENSALVVTDDYPAYIVPELLEKVSKKIRCKFLVVDSNSIIPLSFYGEFVSAARILRPRVHRLFPEAWKFRSSSKPEKPFREKGDSWLEKNPNSPLKRIVWFEGDVDQISEICKNFNFHFQKIPPVPGKKGGREEGIKLLKKFLKRGLSGYAELRSHPKPPEEAYSSFLSPYLRFGHISQEEIVSEVLNWNLNGPWTPGVIIPENKNRKEGYFHPDSNVNSFLDELITWRDVGFLMFWKKPSFRKDLSILPDWIQKNLDFHKNDVRPYIYSKEQLESSSTHDVIWNAAQKELVLSGCMQNYLRMLWGKKVIEWSPDYQTAFEILEEFNNKYAYDGRDPNSYNGILWCFGLFDRPWFPERNVFGNIRTMSSDSTKKKFKLQAYLDYVQSLEERRR
>NZ_CP012029.1|WP_032853362.1|701696_701897_-|hypothetical-protein
MFSFLLLGHTKGYPKLMIDFVKVQKSSKIASNTAFLRTSYVLTFRRTHFLRKAVRFFISANCILNP
>NZ_CP012029.1|WP_002619721.1|700984_701275_-|co-chaperone-GroES
MASIKPLGDRVLVEPRQEAEEKIGSIFVPDTAKEKPQEGKVVEIGSGKYEDGKLVPLEVKVGDTVLYGKYSGTEIKSEGKEYLIIRESDILAVVKK
>NZ_CP012029.1|WP_002730932.1|699330_700971_-|chaperonin-GroEL
MAKDIEYNETARRKLLEGVNKLANAVKVTLGPKGRNVVIDKKFGAPTITKDGVTVAKEIELEDALENMGAQMVKEVSTKTNDVAGDGTTTATILAQSIINEGLKNVTAGANPMSLKRGIDKAVTAAVESIRKRAVKIENKKDIANVASISANNDDTIGNLIADAMDKVGKDGVITVEEAKSIETTLDVVEGMQFDRGYISPYMVTDAESMVATLSDPYILIYDKKISSMKDLIHILEKVAQAGKPLVIISEEVEGEALATIVVNTLRKTISCVAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGMKLENTTLQMLGRANKVTVDKENTTIIEGKGQTKEIQGRIGQIKKQIEDTTSEYDKEKLQERLAKLAGGVAVIHVGAATEVEMKEKKARVEDALSATRAAVEEGIVPGGGLTLLKAQEAVAALKLEGDEATGAKIIFRSLEEPIRMITNNAGLEGSVIVEHAKTKKGNEGFNALSMVWEDLVSAGVVDPAKVVRSALQNAASIGSMILTTEVTITDKPEKDAPNPMAGMGGGGMGGMGGMM
>NZ_CP012029.1|WP_002740412.1|698443_699112_-|SIMPL-domain-containing-protein
MKKLLALLLLTIPFLGIVSETKQTITVSGSGSAIVETDYVQINFSVEVEDPDPKAAQEKNLERTTNVIKTLSKGFKIATKDIYSTDYTLQRQYLQEGKQRPYLASSGILLKLRDLKLYKDLLLEVQKLGVNNVSGIEFKADSTKKQEKEAFTAAYEDAKNKALVLAKSIGKTNVIALKVVESDSMLNPQVVYLMGKVSSNHSPISIGERTIQTKVNVEFEIQ
>NZ_CP012029.1|WP_002740353.1|694726_697420_-|DUF1554-domain-containing-protein
MLESKRKSIIPLIYKGMRILKSSVDRIIASICSQSASSAGWISRSRKPLQKQNRGPRYKKVYSIFFIWITVLLIGCSGENSNPGIGAISMGSIKDSFLNLIHSHSSNQSLIPSSGLYVFVSSYTNNASVPPLSHNGSFGGVAGADAYCNSHIPSSLTGTGSYKAMLVDGTNRIATTVGATSSTGQKDWVFEKNTSYYRADGNLVFTTNDAGLFDFSNGSLTYSFTDVFSIYDFGIWTGLQSNWKTATSTQLCSSASQPWTSGSVANQGKFGYANHKNASSISAGSIPCQWTSTEDPEDPQASVEMGILCVQEKPITLKGKIGFLEDEQCHHSNSYFTIPWKQCHEFKRHFDPVSGAAISSDVPSPGSYRPVPGQVHLNFFNSAQTNPVGCYISNLQSDLDGNVSGQINNCLKSNPAPDKVRITLVLDYKTNLAYNNSIGTIRSLWEKTAISALNYLPYDQSKFFQTLFVDPNTHKDQVEPYFEVVLSLNPYWNATTRTFDLGIVNILNSIPASMTNSLRLTLSNWQGLVELHNRLKNESVDKIQFDMFQNDPTRNCIRCYTVNFISTYGSGGSAGNLYFSAPNGDNLPTIYPVDSSLGHEFGHTVTSTVAPWLLQGVIRNWGGQYIDQNQIYYGQIHNSNQYQDMGTAFGEGIVNSIGRYLISGNQGAWKLGPGIPLYIGTYKDGWKLNPIVDQKYSDFQRFRREMSVRGILENSPDWTSRLQAIQNLNSNFTDHKTNSNNEARYDGFVHYLLQTPPFHIDSYHATDPEVASQLNQIQYRYDQMKLLGEILDGGPANFKWVSYGDVVHPKNSRVSLKDLLVTLGEMHDGSPLPQNGSPGFTDAYLSIKSPFSPQSLGWRLVQKGLISKDEVNNLYRAVGMDQLANICGYPWALPNCQ
>NZ_CP012029.1|WP_002740315.1|694328_694625_+|hypothetical-protein
MLGAYEPVGMVVLIEDGKKTILSNSVLYESKEDRDGVLTSGMEKGLEISYDRFARNVGFDLKKQNFLILFRNKQIIRKNSILIRKNPFRLVLTFQKEI
>NZ_CP012029.1|WP_002732825.1|692705_692924_+|hypothetical-protein
MTGKLNSIYERNQEELLPDFEFYRNRNCRVYISFSDGKRVKTYNKRKDLFFRNDWKIDLFKNGFDSFSLTKE
>NZ_CP012029.1|WP_002732834.1|692209_692707_-|DUF1579-family-protein
MSKEKFEISKREGVHKEFESYTGNWKGVNQMMFKEGEVTDESPIFGNIKLILGGRFLLHEYKGSYGGEPLEGIAIYGYHIDKQRYESAWVESFGMGTGILFSEGSPGAKEWSFTGHYGGETPETSWGWKTSLEKDGDDRLIIFSQNLRPNGEKAGGVRILYERIS
>NZ_CP012029.1|WP_016757377.1|690515_691751_-|ATP-grasp-domain-containing-protein
MKEKGYFLSIGAGPNQVPLISAAIGLGYSVIAVDRNNHAPGLSMSSLRIMESVTEYRKILKTVSEIPLQGKIVGVGTRSYGKATYTASYIADKLKLRYASLESVEICSDKNLLKETAKKIGILTPENYDISTLKNQFPFVYKPSQGSGKEGIRTFHDPKEWESFLKSKKKNSRSKTSLSKKKTNEEWIAEEYIPGFEITVCGLIQDGTFFPASISHKDVTEYSPYLEIAHTLPFSRCELIGEILLNCRALAAAARMKDCPFVAEFRINPQGEIYLIEAVPEVGGEFLADVLIPNYFGSSYFKNLVKLLTGEKIEPFLNYSKIPKKYAGIFFSAPPEGKSKLVEHSEFVIKGKEKIMFDRKLKQNGEILRTSEGNAARTRSVGVLGPDQNDQTLENWKKSVLQRLEGKFESV
>NZ_CP012029.1|WP_002740493.1|703940_705377_-|adenylate/guanylate-cyclase-catalytic-domain-protein
MHFSLFYKRIFFKIDFSFRKELIYNPEVSILNFVNILLSIKKALHTLDRKSMPDSVLEVLKKEERSGIIITNYFRYLIALFFLVQIVVNVNSGNYKFNLVAFSIYLGLTFAHTIIIRISPLSIVSVFNYVTLFAEYALILGVLLFYTFTTENVDLGFALKNPINLFFLFPIVYSLLQFKIRFVFIGLFLFYLIYYSILWIAISQNQLVYTKDWGRYVSGPNILVEDIVAGKPGLYFCFAMMISMGIFRTISMVKRIGIVEGQKTELSRYFSPKIVNEMVENPETFQNGNRQIVSILFLDIRNFTSMSESMDPKELGELLSEFRKIMTECVFENNGTLDKYIGDAVMATFGTPRPSPSAEVDARNAVGCGVIMQKRLSEWNLLRKSEGKVPISIGIGIHTGEVFAGNVGSDLHREYSVIGDAVNTASRIESLCKILKKPFLISKETMELLGGKYTLNRMPRVKVKGKEEPLQIYEVVWG
>NZ_CP012029.1|WP_032853361.1|706227_708489_-|TonB-dependent-siderophore-receptor
MKKFRPLTYRRSYPIDVVRCFFHFLLSVMSLGNFLFPIEVTAQELSPYKKKPKKESANKENKDIGPEDVNRSDGILVKGYRTRGLTGMKQNVRLKDIPATVNIIDDHELKTRSADQWLSAISYTPGIFVIRNYGGFNTLTIRGLDSRNVLLLKDGVRDDTFLIQNSSPMSNFANVERIEILKGPNSVLYGQGAMAGVINIISKKPQKKASYELSLTEGSFGTHRASAGATGPIGTESIRYRIDAATSQYKGFRQNSYALNNVASSLEWDISQKHTLSLFSGKTFDFTKPDAGLPKSKNPKIDLVEPGISLNNNYNTNDDYLKSNSGNFKIQLDSKFSNILSMKSFISYSPQTYYYFAAEDLSHSSIDKNIIERDHLHFETKRSPLQGTVELNWTFRTGFRHKLLSGYEYHWMVSRHRRRYFPQGTTSINIQYPKIEPVGPLPENFTDRKTLYQQMHSLYFQDLMEFSETIKFLLGGRYDSWIRENRTEKLYDLNDNYVSRPASSFNRTRTRSDAKVFTYRVGLIYQPLHYYTTYIGYSTAFIPVTFINTSGKQLRPEMGEQIEIGQRIEFAKGRVQLTGALFTAKKYDVAVLINSRPPLYDQAGELRTNGYEFNIDFHLTKEWSFKSGYAHTIAEWESFRLTDSKGNETDYKGNRPINVPRNTANFWTTYTFSSGFGFGLGGRYVDSIAADNANSFFIPPYGLYDVSVYYKYSYYYFQINCTNVSNKRYFISSIPNPTPGPPRQFLFTVSGKF
>NZ_CP012029.1|WP_002730763.1|709214_709607_-|hypothetical-protein
MNFKLRSFFIFFALFVLVETSLYSKKKTNSPTPKVSGYELVSNPSAAFGKTIQISGTVSEILYKGNSIRFLVHFSGKPVALDSDSTSLISSVQVGSYVSVCGFYLKDRELKSNGVLTSMPFILVDSPNCK
>NZ_CP012029.1|WP_002730926.1|709620_710268_-|hypothetical-protein
MASLSDKARATYLVLLILFLLGIGFFVFDYFQIINAAELLPFLRKEPALVNQDNESPTELQKLEFAKAQERFAEELDELEKRKAELLTEKGKLEVEMEKLEEMRQGLITKEKEMKSADSEKNSRQKLVKVLADKVGNMPPESAVGMLVNWPDGDIIDVFIQMDKDAEDDGRPTITTYLLTLFPADRRAMITNKWLSRSSGIKTPGIPDDAIEANP
>NZ_CP012029.1|WP_002730765.1|710426_710993_-|flagellar-export-protein-FliJ
MKRFQFNLEPVLSLRKKKEDEKLKSFSLVAGEINQIRNSIRENEKQIEFLTEDSDSLRGASLRDYQLHQGYIRSLITRNENLESNIEDKKPELDAKRAELILAQKDRKILEILKENQYKAYKKLYFKKEKFELEEHYNQLKSIQWRKNHASFEPEPAPRIFTYDTGSRTENDGSGASEIKKLYDKYKK
>NZ_CP012029.1|WP_002730920.1|710996_712361_-|flagellar-protein-export-ATPase-FliI
MIEKKFHEKIDVMSKYFLIMDRTETIRKSGKVIRVSGNVIYSEGPPDSKIGELMDVQKSGKEGYLQCEIVGFEGHVYTLMPLGPIEGIYPEAFVFSSGRKLAIPVGKELLGRVLNGVGRPIDKKGHIITKEERGPDNDVPNPLDRPIIRDILMTGVRAIDGILTIGRGQRVGIFSGSGVGKSSLLGMIARYTNADINVIALVGERGREVNEFIEIDLGKEGLQKSVVLAATSDAPKMEQVNCALLATSIAEYFRDQGKHVNLMMDSLTRFAQANREISASNHEPPITRGFSSSVFSKLAKLVERSGTSKSGGTITGFYTVLTEADEMEDPIADAVRGYIDGHIVLNRKLAEKNHYPAIDVPASLSRVMTRIVPENQNLRAGMIRELISVYNSAEELIRLNAYVSGSDSRVDLAIRKKDKIDRYLKQKIQERSTYSKAVQGLKEILEDEQEKEEF
>NZ_CP012029.1|WP_002730816.1|712666_713590_-|flagellar-assembly-protein-FliH
MAKLVFKPIQIADIKDQVELAIPDKYRKFHRDEDAEEFEVDQEGNIIEQYQGPSIEEIEAELSRYREENEEQVRKLLEDARRKSEEIEEEGRKRAFQMIQDSKEKVKLEEDTGKAKAEQILDRAKMEVERMIKEAEMKVAEIEHEAYLKGYDAGREVGFKKGQGEVRRLIDRLGTIVGKAIDIREEIIQASEKQMVEMILIIARKVIKDEIIERKEIVLNNIREALKRIKDRDRVDIRVNFADLELTTAHKDELIKLMESLRKVNIYEDSRVDRGGVIIETDVGAIDARISTQLKEIEEAIRNAEPI
>NZ_CP012029.1|WP_002730732.1|713593_714562_-|FliG-protein
MDPLSSRQNRAGSLLRILGEHLPPEVYRHLGPEATGKLLETFHKTGKPDSKEEREILSSFLNSLSKIRKEESIDPESLNLIRELEALLKEEQEEKDLLKELKTKNAVEISRIVSGEKPSMIALILCFGNPDAAAAVLNDFPEKMKEEILIRIHDLDLSSEYEKNRLERFLKFKLEALALEEKSFPINNPMGKKAADLLGRLRPGDSQKIFDRIREKRPGFAENIMEHFFRMEDLLYLEREPLNRFFSSFHPIVLACALKGTETEVQTRILEKLEPALSSSIRLESDSMGPISLAEMETAQNGILEKLRDEIEEGSIKFWRAT
>NZ_CP012029.1|WP_058331074.1|714561_716265_-|flagellar-basal-body-M-ring-protein-FliF
MPEQVQKILSNIREFFTTLDTTKKLILGGVALTVLVAIGILSTISLQKNRVVLFKDLTSKDFAEVTKKLDSLGYQYGSSDTSVITVDPEQRQEIVTKLAQENLIPAGVQGWELFNVDKFTETQFDKDIKKYRALKGAIEQSLMTLRSVDKAYVNIAFPEDELFSSNSSPVKASVILHYIPGIESLSRKEVKGIVNLVSRAVPKLKPENVSVADADGKIISDFEEDLEKERLELRIVQEKLRIGEEQRIQRLIDMRNTLRWLLGGEDRVDITRFEYNLNWDKESYKDNSVSPVVAIPDNPNTPYSELKLVDGYSLKVSSKETKEDFKGRGFTPDGPAGTEPNIPPGYKDTDYQKSEYSKSENINNYEFNRRVSEVQKQPWKVEKVNLSVVIDGMWEKKEKEDGTGYDRKYIPVSEDELRQIRKNLESAVGIDKARGDQISVITIPKDRSSQFAAEDEELRKQKAIRQMIIASLVIILLLIVSILVYRAIKKEIARRRRRLREEELAAQQQMMREAALRVMDEGGAEVELSLDEKYRRELLENAINLAREKPEEVAQLLRTWLSEEEAS
>NZ_CP012029.1|WP_058331075.1|716769_717249_+|DUF1564-domain-containing-protein
MDILLLDDGQKIESTLVENSVGTDSLLVPDVYWNRLNAQEKIALRGKLPLLLRKYSKQIASMKRLHNRAGKIKYNRGVGKMKKLSIRVHTGVWATLSILAAAHGVSRCYLFNYMLWLEELGGKEDFFVKSFNRGVPSFHWTYKMTWKIDRRQNLISREL

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Crispr_ID: NZ_CP012029_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012029_3

2938442-2938534

TypeI-E

I-E,II-B

Consensus_repeat	Method
AGCCTATTCCCCACATGCGTGGGGTTGAACC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6e,cas5,cas7,cse2gr11,cas3

The CRISPR arrays of NZ_CP012029_3

>merge|NZ_CP012029|3|2938442-2938534|CRISPRCasFinder
AGCCTATTCCCCACATGCGTGGGGTTGAACCGGGGGGTTGTCCATGATCGGAGAGATGGGCCAGCCTATTCCCCACATGCGTGGGGTTGAACC

>NZ_CP012029|3|3|2938442-2938534|CRISPRCasFinder
AGCCTATTCCCCACATGCGTGGGGTTGAACC	GGGGGGTTGTCCATGATCGGAGAGATGGGCC
AGCCTATTCCCCACATGCGTGGGGTTGAACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012029.1\|WP_004278230.1\|2938631_2939783_-\|DUF5009-domain-containing-protein	unknown	unknown	gnl\|CDD\|226749
NZ_CP012029.1\|WP_002734000.1\|2940073_2940394_-\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NZ_CP012029.1\|WP_002734173.1\|2935690_2936236_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_002724112.1\|2937983_2938403_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	pfam09707_cas2_CAS-I-E	gnl\|CDD\|378244
NZ_CP012029.1\|WP_002743741.1\|2950181_2950916_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|132716
NZ_CP012029.1\|WP_002744116.1\|2937166_2938051_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NZ_CP012029.1\|WP_077022130.1\|2941211_2941418_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_004278456.1\|2927562_2930358_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|182031
NZ_CP012029.1\|WP_002724094.1\|2941535_2942900_+\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NZ_CP012029.1\|WP_002722868.1\|2931975_2932512_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09731_cse2gr11_CAS-I-E	gnl\|CDD\|187862
NZ_CP012029.1\|WP_002722873.1\|2935413_2935671_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_032853231.1\|2947865_2949998_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP012029.1\|WP_002724063.1\|2936318_2936663_-\|DUF962-domain-containing-protein	unknown	unknown	gnl\|CDD\|377609
NZ_CP012029.1\|WP_002723941.1\|2950922_2951318_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012029.1\|WP_002723955.1\|2943934_2947108_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226220
NZ_CP012029.1\|WP_002724114.1\|2947207_2947864_+\|thiol:disulfide-oxidoreductase	unknown	unknown	gnl\|CDD\|183298
NZ_CP012029.1\|WP_002744127.1\|2942896_2943931_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP012029.1\|WP_002722881.1\|2934596_2935397_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09727_cas6e_CAS-I-E	gnl\|CDD\|215025
NZ_CP012029.1\|WP_002744104.1\|2933582_2934326_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	gnl\|CDD\|187776
NZ_CP012029.1\|WP_002744115.1\|2932508_2933582_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153

Protein	Function_ID	Function_description	E-value
NZ_CP012029.1\|WP_004278230.1\|2938631_2939783_-\|DUF5009-domain-containing-protein	gnl\|CDD\|226749	COG4299, COG4299, Uncharacterized protein conserved in bacteria [Function unknown].	4.2189e-54
NZ_CP012029.1\|WP_002724112.1\|2937983_2938403_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|378244	pfam09707, Cas_Cas2CT1978, CRISPR-associated protein (Cas_Cas2CT1978). This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteristic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.	7.16526e-34
NZ_CP012029.1\|WP_002743741.1\|2950181_2950916_-\|histidine-phosphatase-family-protein	gnl\|CDD\|132716	cd07040, HP, Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction. Catalytic domain of a functionally diverse set of proteins, most of which are phosphatases. The conserved catalytic core of this domain contains a His residue which is phosphorylated in the reaction. This set of proteins includes cofactor-dependent and cofactor-independent phosphoglycerate mutases (dPGM, and BPGM respectively), fructose-2,6-bisphosphatase (F26BP)ase, Sts-1, SixA, histidine acid phosphatases, phytases, and related proteins. Functions include roles in metabolism, signaling, or regulation, for example F26BPase affects glycolysis and gluconeogenesis through controlling the concentration of F26BP; BPGM controls the concentration of 2,3-BPG (the main allosteric effector of hemoglobin in human blood cells); human Sts-1 is a T-cell regulator; Escherichia coli Six A participates in the ArcB-dependent His-to-Asp phosphorelay signaling system; phytases scavenge phosphate from extracellular sources. Deficiency and mutation in many of the human members result in disease, for example erythrocyte BPGM deficiency is a disease associated with a decrease in the concentration of 2,3-BPG. Clinical applications include the use of prostatic acid phosphatase (PAP) as a serum marker for prostate cancer. Agricultural applications include the addition of phytases to animal feed.	2.02956e-10
NZ_CP012029.1\|WP_002744116.1\|2937166_2938051_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	1.5972e-140
NZ_CP012029.1\|WP_004278456.1\|2927562_2930358_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	6.26738e-138
NZ_CP012029.1\|WP_002724094.1\|2941535_2942900_+\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	4.74451e-19
NZ_CP012029.1\|WP_002722868.1\|2931975_2932512_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|187862	cd09731, Cse2_I-E, CRISPR/Cas system-associated protein Cse2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;.	2.06433e-29
NZ_CP012029.1\|WP_002744104.1\|2933582_2934326_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|187776	cd09645, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	6.23833e-52
NZ_CP012029.1\|WP_032853231.1\|2947865_2949998_-\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.72437e-33
NZ_CP012029.1\|WP_002724063.1\|2936318_2936663_-\|DUF962-domain-containing-protein	gnl\|CDD\|377609	pfam06127, DUF962, Protein of unknown function (DUF962). This family consists of several eukaryotic and prokaryotic proteins of unknown function. The yeast protein YGL010W has been found to be non-essential for cell growth.	4.23805e-40
NZ_CP012029.1\|WP_002723955.1\|2943934_2947108_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|226220	COG3696, COG3696, Putative silver efflux pump [Inorganic ion transport and metabolism].	0
NZ_CP012029.1\|WP_002724114.1\|2947207_2947864_+\|thiol:disulfide-oxidoreductase	gnl\|CDD\|183298	PRK11752, PRK11752, putative S-transferase; Provisional.	1.48245e-71
NZ_CP012029.1\|WP_002744127.1\|2942896_2943931_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	6.22957e-25
NZ_CP012029.1\|WP_002722881.1\|2934596_2935397_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|215025	smart01101, CRISPR_assoc, This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	7.80562e-65
NZ_CP012029.1\|WP_002734000.1\|2940073_2940394_-\|multidrug-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	9.99826e-27
NZ_CP012029.1\|WP_002744115.1\|2932508_2933582_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	3.16139e-117

>NZ_CP012029.1|WP_002724112.1|2937983_2938403_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MVVLILERVKTSQRGEMSRLAIELKPGVFVASINARVRDRIWKKISEEWKSDAIMLFSSNSEQGYGIRSHGDPSREIMDFDGLLLMSKPDPKRDQIEVMNDSDFSITTEDEVSPFSDLKGFFNEKANRLLLEADVPDES
>NZ_CP012029.1|WP_002744116.1|2937166_2938051_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MPNRNLQELPKFEDNWSHLYFEKGRIDQFQKSIGFHYLDKVVPIPIETIGLLLLGPGTSITHEAIKRISDSRCLLAWTGEGGVRFYSAGYTGTYSARNLLRQVEAYGNPKERVSVIRKMYQFRFSDEISADATIEQIRGLEGARVRKIYREWSENSGVPWKSRSYDQNSWDWSDPINRALSSANACLYGVVHAAILQSGFSPAIGFVHTGKQLSFVYDIADLYKAEITIPLAFEITAEDATNVERRVRFACRDKFKHSKLLKRIIPDIKELIYGGFDFGESEDFSEGRDVAVSH
>NZ_CP012029.1|WP_002724063.1|2936318_2936663_-|DUF962-domain-containing-protein
MTTEATPKTYATFKEFWPFYLGEHSHPVNRALHFIGTSFAIGWILAAIANFNPFYILTGLFFGYFFAWIGHFFVEKNRPATFTYPLKSFMGDWVMYFYILTGQIGKELEKIGKK
>NZ_CP012029.1|WP_002734173.1|2935690_2936236_-|hypothetical-protein
MEKKFSFLLILLPVLFFTINSCSRVWNIGILNQKDNKVTLVLKLRIPVLQHHFQSWITGTEFHSGNLQLPFLDLRNWFRVKSGSITYWSNCWSNQSKFEEKIQLRNIRYNEDRGEVSLELSPKYAYFIDWSNNNNDPRSLIYSYSEIRVESSVGKIAYSGEEILNAFQYDEDCECFLMTLK
>NZ_CP012029.1|WP_002722873.1|2935413_2935671_-|hypothetical-protein
MKKPTNFYTDLMRRRLKPVAIRVEEHKSIVCKIRGDSFVAIRHRLREIGRLLKKSTFASELTLLNTPIRVYESDTENKRTIFAKI
>NZ_CP012029.1|WP_002722881.1|2934596_2935397_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MFLSQLKLDTHNTNNKIVFNWIQNPYNIHQRLWMAFSEYSSKDKPQNSPFLFQLDYNSDPGKISPRILVFSEKLPNWERAFQEFKVLTEIPVGNQIKQISPTFIQAGAVLRFSLTANPTKKLKDYRSLFQEELEGFPDKFDPSDRVSFLEGKSKLEDLKKTLTKDQIQKLKSKRVGIYHEKELLNWLSKKGNDNGFSLLNAVVEFQSDFSANKIKGSLSPSIPKIHTVSFSGILKIMDPALFKIAYTKGIGTGKAFGCGMLLLART
>NZ_CP012029.1|WP_002744104.1|2933582_2934326_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MKDYLVFRLYGPLVSWGNIAVGEYRPSDSFPTKSAIIGLISASFGFDRSEDGKISELVKSVFFATKTLNPGNLLRDYHTIQSPGNVKRSLLTRKDELLDSEYVETILSSRDYRVDAVYDVALSEKKRAPYSLKEIRNALLSPIHTPYLGRKSCSIALPMCPEILSSDSFPNAFEEYNKILMKKYESSDYKDPLADLSSKSSAILYLWEDPTELSEKDHTHSRRDEILNRNRWQFQDRKEFFKSVSKV
>NZ_CP012029.1|WP_002744115.1|2932508_2933582_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MNRFIQFHFLTSYPPSNLNRDDLGRPKTAMLGGANRLRISSQSLKRAWRTSDLFRETLSGHIGTRTKEKGKEIYQKLLDGKIPEKNARTWSKSIAGRFGKLKNPSEKELEKNPLLDLEIQQLTHFSKEENEAISSLIQKLIDSKKEPSNEDLNLLKKENSSSDIAMFGRMLASDPAFNIEAAVQVAHAITVHKVAIEDDFFTAVDDLNSGIEDVGAGHLGEVEFGSGLFYLYICVNREQLLNNLNGNKDLAKRTIKALVETSSTISPTGKQNSFASRARALYCMTEKGNEQPRSLHTAFLNSVEDRGILNAAILKLESSRQNFEKVYGSCASGGFKTFNVDSGNGSLKEILEFAQED
>NZ_CP012029.1|WP_002722868.1|2931975_2932512_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MKFYENKEKYKETIINWWIDLKSRTGDRAALRRCSNGLDTLLIPYTHRLISQLFQEGFQFFPDKIGPIAGILSHIEEDNPSVSFARSMARKEGENPVINEIRFRKILQYSDILSEELFYQNMVRIVKNLKKKANISDLSLSIYSWNQRTKKDWAYDYYGTPISENNLENSENLQGENQ
>NZ_CP012029.1|WP_004278456.1|2927562_2930358_+|CRISPR-associated-helicase/endonuclease-Cas3
MKTEVKSYYKYWGKADKEGNYHLLAYHCFDVAAVGEVYLSQNETLCTHFSRKLGIDPITFKNLFVFFLVLHDLGKFSDCFQSLIPNVKSALDNSNPPIGSYSIRHDSLGYIFWGKWILKDERFGNYDGLLTEQNWLSWNGLRSSKDKSYFTEFLDVLIRCVTGHHGRPPSKNGYSGQTAVSLDSHFTEADRSAALDFSKEVNRILSPNLNFDGDFKTLYNSALRISFWLAGLSVLCDWIGSNAEIFKYHQTPIDLEEYYTKISLKRALEAINRSGLLPSKITFNKDHFRIFEYLREPTPLQKFCSEVAIPDSPSLFILEDVTGSGKTEAALILTHRLMQKSAYSGFYVGLPTMATANGMYQRMSGVYRNLYTKESIPSLVLAHGARNLSDSFQSSVISDNAILADRNYSLQLDKDPEESASAICNIWLSDNQKKSLLADAGVGTIDQALLSILSTKFQSLRMFGLSRKVLILDEVHSYDPYMVELICCLLKAQAKIGASVILLSATLPKILRKTFSESFALGLDTELQDLKSVEYPLVSLISDRSEVEEIPISTRKEVSRKLNVKFLFNQEQVLQKILEMSNQGRCVCWIRNTVSDASQAFSFLHSKLGDQVILFHSRFVMGDRLNIESQILENFGVRSDQNSRKGKVVVATQVVEQSLDLDFDCIITDLAPIDLILQRAGRLHRHCRDIFGNAKQGLDERGEPILWIFSPEPIEDPTSNWFSQFSRGGSMVYSDHGRLWLTARLLQERKGWRMPEDARNLIESVYGIDVEIPQSFRENQFKVKNDKKKLESAAALSTIHLELGYDSTLNETSWDDSKFSTRYGIDNSSKAVLAKFVSDRLVPWISGTTRDWQNSELPVPNYLVEKEFIFENLNFSEVISNCKKNLPDKGKHCVLLPLFYTNNSWRGKALNKKNEVVSFTYDERFGFRKEK
>NZ_CP012029.1|WP_004278230.1|2938631_2939783_-|DUF5009-domain-containing-protein
MEKKSTQNKDRILSLDLFRGMTVVGMILVNNPGSWSYVYSPLKHAEWNGCTPTDLVFPFFLFAVGTSIPISLYSKNGINRIRVWIGICIRGISLILLGLFLNFFGEWTFSELRIPGVLQRIGFVYWVVATLFLIFPGKKVLVFLIPILLVHTWILTHIAPPGESMVSLEQGKDIGAWIDRTIFGEKHLWKFSKTWDPEGFLSGIASIATSLFGVICGFILFRREGRGKNRVLSIFGLGFLFTFVGLLWDRSLPMNKSLWTGSYAVYTTGLSFLCIGFFEYLDSLILLKKWNDLDLKIFFQPFFVFGKNAILVFVGSGILARTLNFWTIVLENGKSVGVKVWFFSKLVLFADPYLASLLYAVLHLSVWWGILSFLDKRKIYIKV
>NZ_CP012029.1|WP_002734000.1|2940073_2940394_-|multidrug-efflux-SMR-transporter
MAWIYLIIASTFEIGFTTCLKLSDNFTKPTWIGGFVVSAVFSLAFLNKAVQTIPMGTAYAIWTGLGAAGTILVGIVIHGEPIDFWRGFFLSTLILSVLGLKFLVSE
>NZ_CP012029.1|WP_077022130.1|2941211_2941418_-|hypothetical-protein
MWRTENVFDSVVLDLIESSGQNRERSLYFPSKEREGGNFSFSIGNAPSFAQTFFGSAFSEGKGTDEKR
>NZ_CP012029.1|WP_002724094.1|2941535_2942900_+|TolC-family-protein
MYGSTKCFFFIHIIQFIIIFFFSFEILSKNDGDSLAFFEEYLSKEKFDSPKRIKIDLKKAEETFLRNNLSLLAKRLEIEASKAEIIQTHLWDNPILSIDQNIYNQNTNRYLDTTRNGQTTIQIEQIFVLAGKRDKRIRIAQWNTNTKEQDFYDLLRALKLELRVTFYKLSFLKKSLEFFDENINSIRKTIKSSEAVYKNRDILLSEVLRLKSILFRLETDRSEIVSDIIEKENILKLLLNEPNYSEAILEIETTDLDEKRNSILAKSDQELLSIAFEKRPDLKALEFGIKAEQTNLALQRSLAIPDLTLGGSWDRAGNYINNYYGFTVSISIPTFDRNQGNIRESELILASKKAKYEEKKIKIKAEVLSAVGKAKEKERLLLEYKNSFTKDYQNLASLMVENYRKKYLTILEFSDFFEAYSDSFLKMLRLQSDRIGSLESVNYTLGSTVLEIGR
>NZ_CP012029.1|WP_002744127.1|2942896_2943931_+|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MILKNIFSSLILFYQTRLKSILFAGFLILTLAIFLHNRDLSKKTQEHRKLEKATSPQVTEAGAKIEFPKDYPGLARLVYQKIRKGNADFSVMASARVIASINTSVNSGEKLILFDSGETTHLYSEYKRTRVVASKAFKDLTRVRDMYVNQAATRRDVTEAESNFAVAKAEGAEAESKLRTIGFNPKELDSVSGTSYWIICDVPESQLSEVENGEEVKIQFPSFPGKIFLGKAEAIGEVIDPVLRTVKVRATLKNTKEKILPGMFARVDFGDPRSSILAIPNRAIVTVDEKNYVFLKENEHSFRRKQVVLGSSGEERTIIKEGLSEGDEIVIDGAFLLKGISFGF
>NZ_CP012029.1|WP_002723955.1|2943934_2947108_+|efflux-RND-transporter-permease-subunit
MVERLIEFSLKRRIPTILLALFVFGIGLWSWNTLKKEAYPDVGDTQVTVIALLPGKAALEVEKQVTLPLERELNTVPYVLTRRSKTIFGLSVLQLIFEDGVSDFTARELVLEKIRNADLPQHANLSLAPLTGPVGEIFRYTIEAGEEWSGMDLRTIQDWIVIPALRQVNGVADVINFGGLVKQYHIITSPNRIYRYNLSIRDVIETISSNNRNTGGHTLTRGDQSFAVRGLGAIQNTDDIRNTVIASSGGTPIYIGNLASVEEYPKQPDGIFSYALKDPHSSNIKLRESGVQGLIAMRRGENPSEVVERVKEKLEEINRNYLPKGVRLTTTYDRSDLVNFTVNTISRTLFEGISVVVLVLIFFIGSVRSALVVACTIPLSLLFAFSLMKVTNIPANLLSLGAIDFGIIVDGAVVVVDNISRKYKEAKGKKISGLSFKEIETLTIEGTKEVGIEIFFSISIIILAYMPIFTFQRIEGKLFSPMAFTLSYAISGSMLIALTFIPVLMTFLYRSKLEKNGNDSLEWQNPIFIKIQNFYSLFLAKRLVDPKKVVAFTWILVLGIGSFSYFRLGIEFLPELDEGSINIRCFFPVGISLKTSEKYVPIIRSTILKHEQVSSVLTQLGRNDEGSDPYGPNRLEILVGLKDYSVWKEKISKRQLLSKIKKELQENLPGIGFLFSQPILDNVTESVTGSVSDLAILINGEDLNILRNLGEQILTTISEIPGATESGIEQEGDQTQLTIEINRKQAARYGINTSEILDTMEAAIGGKKVGMLYDDFKRFEIVVRYTNDFRSSIDSVRTLLVTGPGGARIPLSELANINFKDGPTIIQRQDGKRQISVRTNIRGRDQGSFAAEAKELVAEKIKIPEGIEIHWGGQFENLHRAVSRLRFVIPLTLFAIFLILYVMFKTPQMVLLAMSGIPISISGGLLALLFRGTNFSVSAGVGLISLFGISTMTGVLFISRLLHMLEKNQNKDLKSSVIEAAVIQLRPRIMTVLLALLGLIPAAIASGIGSDIQKPLATVIVGGLTLELLVTLVYIPSLFYLTEKRKRIVPNSSNKNG
>NZ_CP012029.1|WP_002724114.1|2947207_2947864_+|thiol:disulfide-oxidoreductase
MIELYSASTPNGRKVSIMLEELGIPYTIHPIDLDKLEQKQEWFLKINPNGRIPAIIDTDNGNFAVFESGAILIYLAEKTGKFLPKDPKEKSIALQWLMFQMGGVGPMQGQAGVFLKYAPEKIPFAISRYQNETKRLYSVLDRRLGESQFLAGKELSIADIATWPWVNIHDWVEISLDEFPNLKRWNEELAERPAFIKGKNIPNKTNHKNNTEEIKKKA
>NZ_CP012029.1|WP_032853231.1|2947865_2949998_-|sensor-histidine-kinase
MTNSKNHSRFSAFDFGFLVFWISVILVIASFFGNYYYEERHLDRLIDNIHWTVSYLCAAALAWLGYFSAESGIHRFRLWFALGLTANALGQFSWAVQVYLDYYIIPTPSDYLFPWVAPCFVIGYSIIVIECDRSRIRTAVLDGLGLITAILTFSLALYLPQREGVGISQLLPLINHPVSFLTAAALGVLLIPLLRLQPDKSWFFFILGMGGTGLCWLLWNAFFIVQIPPDGTVLNAGFSVSALILGYGALTWEPKFNDCPVWGRRFEAALRLLPLFEVVASSITIVLAGTLSGLPEGVRIIAWTGTTIVVVIASARQTFLVKEMANAEQEIRLINEGLEGIVAKRTEELRTVNQYLTSKNEQVIRAIENLKSTQKQLIRSEKMAVLGQLVAGIAHELNTPLGAIVSSNEGIRSILSNSWEGLLRSYSRFTEEEKTIWEKLFSKGIALREFYDTREERAKRKKIAVLLNDFGFSEVMRLADMLTDLGISPDYVSENFKNLPQKEKLIMIVQNALSLSGLARASFTIEKAAEKASLVIQALKEYAYKDPAETTMGPVDVRKQLETVFTLYYSKYKTQVEIVRDMPEISCVWGNSESLTQVWINLIGNALYAMHYKGKMIISCKRVQTGLEIAIKDNGNGIEDTIRDRIFEPFFTTKPSGAGTGLGLDICRRIIEDHNGKIFFETSEQGTTFFVILPVAEPSPEKLENSTFLI
>NZ_CP012029.1|WP_002743741.1|2950181_2950916_-|histidine-phosphatase-family-protein
MSAVHLVRHGQANSQGENYDLLTQHGKNQSFALGKFMAQNGECPDRIVTGTLRRHIETAEFFMQGVISVVGDRKKYKGGFFVHRDEGWNEFSTELWSVYSELLSSKRSEFAKTLSQFGKVRVKGGIRSAALFLKLTEEILRFWREGKETPEGIETYESFENRIFHSSNIWFSSRNQERTFIFTSGTPISLVLNRFLRQDEDCFVWMPWIWNTSLSTFRRIRGKYLPVSINGVPHLPDNLNRTLL
>NZ_CP012029.1|WP_002723941.1|2950922_2951318_-|hypothetical-protein
MQDKPTSTDLLEAIQDFLMKEVLPQFKDKELLSYKTLVSWNMLGVVSREIRSGEELLDKELGRLVELLNKNLVIPPTLDKKKNLAHVWNVELRDKIRREKLSSENSRYWNHVKETVKEKVEVINPRFITER

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012029_1	1.4\|412518\|31\|NZ_CP012029\|CRT,CRISPRCasFinder	412518-412548	31	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	18149-18179	1	0.968
NZ_CP012029_1	1.1\|412518\|40\|NZ_CP012029\|PILER-CR	412518-412557	40	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	18140-18179	5	0.875
NZ_CP012029_3	3.1\|2938473\|31\|NZ_CP012029\|CRISPRCasFinder	2938473-2938503	31	MH617641	Microviridae sp. isolate ctji855, complete genome	200-230	6	0.806
NZ_CP012029_2	2.1\|703860\|32\|NZ_CP012029\|CRISPRCasFinder	703860-703891	32	KJ608188	Enterococcus phage EFC-1, complete genome	23247-23278	7	0.781
NZ_CP012029_2	2.1\|703860\|32\|NZ_CP012029\|CRISPRCasFinder	703860-703891	32	NC_028671	Enterococcus phage vB_EfaS_IME197, complete genome	5787-5818	7	0.781
NZ_CP012029_3	3.1\|2938473\|31\|NZ_CP012029\|CRISPRCasFinder	2938473-2938503	31	MH617287	Microviridae sp. isolate ctgh839, complete genome	203-233	7	0.774
NZ_CP012029_3	3.1\|2938473\|31\|NZ_CP012029\|CRISPRCasFinder	2938473-2938503	31	MH617108	Microviridae sp. isolate ctci907, complete genome	209-239	7	0.774
NZ_CP012029_3	3.1\|2938473\|31\|NZ_CP012029\|CRISPRCasFinder	2938473-2938503	31	MN862333	Trichosanthes kirilowii gokushovirus strain pt111-gok-1, complete genome	1511-1541	7	0.774
NZ_CP012029_3	3.1\|2938473\|31\|NZ_CP012029\|CRISPRCasFinder	2938473-2938503	31	MH617159	Microviridae sp. isolate ctcd790, complete genome	197-227	7	0.774
NZ_CP012029_3	3.1\|2938473\|31\|NZ_CP012029\|CRISPRCasFinder	2938473-2938503	31	MH617600	Microviridae sp. isolate ctci143, complete genome	179-209	8	0.742
NZ_CP012029_3	3.1\|2938473\|31\|NZ_CP012029\|CRISPRCasFinder	2938473-2938503	31	NZ_CP049040	Pseudohalocynthiibacter aestuariivivens strain RR4-35 plasmid pRR4-35_3, complete sequence	32956-32986	8	0.742
NZ_CP012029_2	2.1\|703860\|32\|NZ_CP012029\|CRISPRCasFinder	703860-703891	32	NC_042136	Vibrio phage VP4B, partial genome	151189-151220	9	0.719
NZ_CP012029_3	3.1\|2938473\|31\|NZ_CP012029\|CRISPRCasFinder	2938473-2938503	31	MH616998	Microviridae sp. isolate ctdc857, complete genome	338-368	10	0.677
NZ_CP012029_3	3.1\|2938473\|31\|NZ_CP012029\|CRISPRCasFinder	2938473-2938503	31	MH616799	Microviridae sp. isolate ctch65, complete genome	212-242	10	0.677

1. spacer 1.4|412518|31|NZ_CP012029|CRT,CRISPRCasFinder matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 1, identity: 0.968

ttcgagagagcagggatttctattgccagtg	CRISPR spacer
ttcgagagagcagggatttctatcgccagtg	Protospacer
***********************.*******

2. spacer 1.1|412518|40|NZ_CP012029|PILER-CR matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 5, identity: 0.875

ttcgagagagcagggatttctattgccagtgtcggttcaa--	CRISPR spacer
ttcgagagagcagggatttctatcgccagtgtc--tttgatc	Protospacer
***********************.*********  **..*

3. spacer 3.1|2938473|31|NZ_CP012029|CRISPRCasFinder matches to MH617641 (Microviridae sp. isolate ctji855, complete genome) position: , mismatch: 6, identity: 0.806

ggggggttgtccatgatcggagagatgggcc	CRISPR spacer
tgcaggttgtccatgatcggaaagatcggcg	Protospacer
 * .*****************.**** ***

4. spacer 2.1|703860|32|NZ_CP012029|CRISPRCasFinder matches to KJ608188 (Enterococcus phage EFC-1, complete genome) position: , mismatch: 7, identity: 0.781

tgtttcgatgtaatcgaatttctttgctttgc	CRISPR spacer
ttctgcaaagtattcgaatttcttttctttgc	Protospacer
* .* *.* *** ************ ******

5. spacer 2.1|703860|32|NZ_CP012029|CRISPRCasFinder matches to NC_028671 (Enterococcus phage vB_EfaS_IME197, complete genome) position: , mismatch: 7, identity: 0.781

tgtttcgatgtaatcgaatttctttgctttgc	CRISPR spacer
ttctgcaaagtattcgaatttcttttctttgc	Protospacer
* .* *.* *** ************ ******

6. spacer 3.1|2938473|31|NZ_CP012029|CRISPRCasFinder matches to MH617287 (Microviridae sp. isolate ctgh839, complete genome) position: , mismatch: 7, identity: 0.774

ggggggttgtccatgatcggagagatgggcc	CRISPR spacer
aacatgttgtccatgatcggaaagatgggcg	Protospacer
.. . ****************.********

7. spacer 3.1|2938473|31|NZ_CP012029|CRISPRCasFinder matches to MH617108 (Microviridae sp. isolate ctci907, complete genome) position: , mismatch: 7, identity: 0.774

ggggggttgtccatgatcggagagatgggcc	CRISPR spacer
tagatgttgtccatgatcggaaagataggcg	Protospacer
 .*. ****************.****.***

8. spacer 3.1|2938473|31|NZ_CP012029|CRISPRCasFinder matches to MN862333 (Trichosanthes kirilowii gokushovirus strain pt111-gok-1, complete genome) position: , mismatch: 7, identity: 0.774

ggggggttgtccatgatcggagagatgggcc	CRISPR spacer
tgcatgttgtccataatcggatagatgggcg	Protospacer
 * . *********.****** ********

9. spacer 3.1|2938473|31|NZ_CP012029|CRISPRCasFinder matches to MH617159 (Microviridae sp. isolate ctcd790, complete genome) position: , mismatch: 7, identity: 0.774

ggggggttgtccatgatcggagagatgggcc	CRISPR spacer
tgcatgttgtccatgatcgggaagatgggcg	Protospacer
 * . ***************..********

10. spacer 3.1|2938473|31|NZ_CP012029|CRISPRCasFinder matches to MH617600 (Microviridae sp. isolate ctci143, complete genome) position: , mismatch: 8, identity: 0.742

ggggggttgtccatgatcggagagatgggcc	CRISPR spacer
tgcacgttgtccatgatcgggaagatggggg	Protospacer
 * . ***************..*******

11. spacer 3.1|2938473|31|NZ_CP012029|CRISPRCasFinder matches to NZ_CP049040 (Pseudohalocynthiibacter aestuariivivens strain RR4-35 plasmid pRR4-35_3, complete sequence) position: , mismatch: 8, identity: 0.742

ggggggttgtccatgatcggagagatgggcc	CRISPR spacer
cttgcgcagtccatgagccgagagatgggcc	Protospacer
   * *. ******** * ************

12. spacer 2.1|703860|32|NZ_CP012029|CRISPRCasFinder matches to NC_042136 (Vibrio phage VP4B, partial genome) position: , mismatch: 9, identity: 0.719

tgtttcgatgtaatcgaatttctttgctttgc	CRISPR spacer
taacacgatgtaatcgaacttcgttgctaaga	Protospacer
*. . *************.*** *****  *

13. spacer 3.1|2938473|31|NZ_CP012029|CRISPRCasFinder matches to MH616998 (Microviridae sp. isolate ctdc857, complete genome) position: , mismatch: 10, identity: 0.677

ggggggttgtccatgatcggagagatgggcc	CRISPR spacer
aacatattgtccatgatgggatagatggggg	Protospacer
.. . .*********** *** *******

14. spacer 3.1|2938473|31|NZ_CP012029|CRISPRCasFinder matches to MH616799 (Microviridae sp. isolate ctch65, complete genome) position: , mismatch: 10, identity: 0.677

ggggggttgtccatgatcggagagatgggcc	CRISPR spacer
tacatattatccatgatcggaaagatgggtg	Protospacer
 . . .**.************.*******.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

812161 : 867469

Klosneuvirus(14.29%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002733847.1\|812161_812476_+\|protease	ATP-dependent Clp protease adaptor ClpS	NA	NA	NA	NA
WP_002741574.1\|812814_813351_-	DUF1564 domain-containing protein	NA	NA	NA	NA
WP_002741536.1\|814483_815662_-	MaoC-like protein	NA	NA	NA	NA
WP_032851321.1\|816820_817561_-	hypothetical protein	NA	NA	NA	NA
WP_032854603.1\|817511_819467_+	M3 family metallopeptidase	A0A1V0SID3	Klosneuvirus	9.4e-45	24.5
WP_002731715.1\|819463_819700_-	hypothetical protein	NA	NA	NA	NA
WP_026053921.1\|819774_820440_-	glutathione S-transferase	NA	NA	NA	NA
WP_002727447.1\|820653_821439_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_002741720.1\|821445_822642_+	sterol desaturase family protein	A0A2K9L1K6	Tupanvirus	9.6e-08	26.6
WP_016757337.1\|822696_824832_+	PAS domain S-box protein	NA	NA	NA	NA
WP_032853475.1\|825030_825903_-	hypothetical protein	NA	NA	NA	NA
WP_002727464.1\|825966_828198_+	phosphatidylserine decarboxylase	NA	NA	NA	NA
WP_016749656.1\|828822_829158_+	DUF971 domain-containing protein	NA	NA	NA	NA
WP_002727421.1\|829389_830451_+	flagellar motor switch protein FliN	NA	NA	NA	NA
WP_100219937.1\|830471_831260_+	flagellar biosynthetic protein FliO	NA	NA	NA	NA
WP_002727449.1\|831297_832086_+	flagellar type III secretion system pore protein FliP	NA	NA	NA	NA
WP_002556446.1\|832082_832346_+	flagellar biosynthesis protein FliQ	NA	NA	NA	NA
WP_002727445.1\|832352_833132_+	flagellar biosynthetic protein FliR	NA	NA	NA	NA
WP_002741588.1\|833128_834664_+	flagellar type III secretion system protein FlhB	NA	NA	NA	NA
WP_002741572.1\|834673_836791_+	flagellar biosynthesis protein FlhA	NA	NA	NA	NA
WP_002727425.1\|836842_838144_+	flagellar biosynthesis protein FlhF	NA	NA	NA	NA
WP_002727418.1\|838169_839081_+	MinD/ParA family protein	NA	NA	NA	NA
WP_002727476.1\|839084_839561_+	hypothetical protein	NA	NA	NA	NA
WP_002727432.1\|839717_840518_+	RNA polymerase sigma factor WhiG	A0A2I7SC33	Paenibacillus_phage	2.2e-08	29.2
WP_002727454.1\|840543_842529_+	FapA family protein	NA	NA	NA	NA
WP_011670378.1\|842536_842890_+	hypothetical protein	NA	NA	NA	NA
WP_002741476.1\|842905_844138_+	hypothetical protein	NA	NA	NA	NA
WP_002727460.1\|844137_844419_+	DUF370 domain-containing protein	NA	NA	NA	NA
WP_077022052.1\|844415_844976_+	guanylate kinase	A0A223FN12	Murmansk_poxvirus	2.2e-18	32.4
WP_002731933.1\|845023_845887_-	hypothetical protein	NA	NA	NA	NA
WP_134771585.1\|845921_846446_-	helicase	A0A127AW80	Bacillus_phage	1.1e-29	41.8
WP_002744762.1\|846502_847897_-	DEAD/DEAH box helicase	NA	NA	NA	NA
WP_002731700.1\|848015_849608_-	sodium:neurotransmitter symporter family protein	NA	NA	NA	NA
WP_002741612.1\|849968_852548_+	ATP-dependent chaperone ClpB	K4FB40	Cronobacter_phage	2.7e-116	36.1
WP_002727487.1\|852926_853418_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_100219936.1\|853419_853926_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_107694842.1\|853944_854034_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_002731900.1\|854588_854909_+	hypothetical protein	NA	NA	NA	NA
WP_002721611.1\|855088_856567_+	response regulator	A0A2H4N7Z5	Lake_Baikal_phage	4.1e-24	30.3
WP_002721600.1\|856633_857158_+	hypothetical protein	NA	NA	NA	NA
WP_002721596.1\|857159_857531_+	hypothetical protein	NA	NA	NA	NA
WP_002741452.1\|857536_858931_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_016749660.1\|858945_860343_+	serine/threonine-protein phosphatase	NA	NA	NA	NA
WP_002741540.1\|861565_861898_-	cupin domain-containing protein	NA	NA	NA	NA
WP_050547995.1\|861902_862169_-	hypothetical protein	NA	NA	NA	NA
WP_077022054.1\|862137_862707_-	SidA/IucD/PvdA family monooxygenase	NA	NA	NA	NA
WP_002741712.1\|862655_863192_-	SidA/IucD/PvdA family monooxygenase	NA	NA	NA	NA
WP_032853474.1\|863188_864760_-\|tRNA	class I tRNA ligase family protein	NA	NA	NA	NA
WP_144429902.1\|865273_865573_-\|transposase	transposase	NA	NA	NA	NA
WP_002723507.1\|865530_865779_-\|transposase	transposase	NA	NA	NA	NA
WP_002741488.1\|866179_866740_+	lysoplasmalogenase	NA	NA	NA	NA
WP_002741569.1\|867280_867469_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_2

2171656 : 2237330

Leptospira_phage(38.46%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002724411.1\|2171656_2172004_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_144429904.1\|2172154_2172454_+\|transposase	transposase	NA	NA	NA	NA
WP_002740751.1\|2172364_2173936_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_002721164.1\|2174094_2174547_-	response regulator	NA	NA	NA	NA
WP_002740943.1\|2174539_2175937_-	hypothetical protein	W8CYF6	Bacillus_phage	5.8e-12	25.7
WP_016749152.1\|2176230_2177094_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_002721143.1\|2177180_2178215_+	CapA family protein	NA	NA	NA	NA
WP_050547970.1\|2178812_2179004_-	hypothetical protein	NA	NA	NA	NA
WP_002731998.1\|2179366_2179756_+	hypothetical protein	NA	NA	NA	NA
WP_144429895.1\|2179891_2180083_-	hypothetical protein	NA	NA	NA	NA
WP_002740999.1\|2180875_2181304_+	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
WP_032853105.1\|2181941_2184074_+	TonB-dependent receptor	NA	NA	NA	NA
WP_002740689.1\|2184075_2185239_+	hypothetical protein	NA	NA	NA	NA
WP_002721240.1\|2185605_2186265_+	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_134771539.1\|2186410_2187218_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_002739191.1\|2187386_2188190_-	Fic family protein	NA	NA	NA	NA
WP_016749159.1\|2189294_2189558_-	hypothetical protein	NA	NA	NA	NA
WP_002725152.1\|2191544_2191982_-	dUTP diphosphatase	V9SFR6	Tunisvirus	4.7e-29	47.6
WP_002735362.1\|2192271_2193666_-\|tRNA	glycine--tRNA ligase	A0A2I2L3K8	Orpheovirus	2.4e-50	30.6
WP_002739289.1\|2193779_2195462_+	energy transducer protein TonB	NA	NA	NA	NA
WP_002735385.1\|2195458_2196217_+\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_002725156.1\|2196225_2197128_+	50S ribosomal protein L11 methyltransferase	NA	NA	NA	NA
WP_002725176.1\|2197132_2198119_+	adenosine kinase	NA	NA	NA	NA
WP_002735358.1\|2202558_2203161_-	hypothetical protein	NA	NA	NA	NA
WP_002739328.1\|2203484_2204195_-	DUF1554 domain-containing protein	NA	NA	NA	NA
WP_002725174.1\|2204421_2204613_-	hypothetical protein	NA	NA	NA	NA
WP_002739271.1\|2204611_2206402_+	DNA mismatch repair endonuclease MutL	A0A1B2LRQ5	Wolbachia_phage	4.9e-72	32.1
WP_002739318.1\|2206370_2206991_+	VTT domain-containing protein	NA	NA	NA	NA
WP_002739273.1\|2207061_2207856_-	hypothetical protein	S5WIX4	Leptospira_phage	1.5e-09	54.2
WP_002739321.1\|2209168_2210089_+	hypothetical protein	S5WIX4	Leptospira_phage	2.3e-17	75.0
WP_133175065.1\|2210244_2210364_+\|transposase	transposase	NA	NA	NA	NA
WP_002735333.1\|2211687_2212341_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_002735386.1\|2212592_2212859_-	hypothetical protein	NA	NA	NA	NA
WP_002743875.1\|2213246_2214179_-	hypothetical protein	S5WIX4	Leptospira_phage	2.3e-09	54.2
WP_144429896.1\|2214331_2215606_-	hypothetical protein	S5WIX4	Leptospira_phage	1.9e-06	50.8
WP_002735468.1\|2215816_2216053_+	hypothetical protein	NA	NA	NA	NA
WP_002739275.1\|2216049_2217321_+	replication-associated recombination protein A	G3MBE0	Bacillus_virus	7.2e-70	39.2
WP_002739285.1\|2218138_2219242_-	histidinol-phosphate transaminase	A0A0H3TLT9	Faustovirus	2.0e-20	28.3
WP_002725134.1\|2219944_2220157_-	hypothetical protein	NA	NA	NA	NA
WP_002739315.1\|2221171_2222113_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_002556490.1\|2222168_2222456_-	ribosome-associated translation inhibitor RaiA	NA	NA	NA	NA
WP_002727823.1\|2222630_2223080_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_002727800.1\|2225915_2226857_-	histone deacetylase	A0A2K9L0I3	Tupanvirus	9.2e-46	39.8
WP_002739181.1\|2227274_2228450_+	glycosyl hydrolase	NA	NA	NA	NA
WP_002735477.1\|2228444_2229245_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_002727820.1\|2229244_2229772_-	hypothetical protein	NA	NA	NA	NA
WP_002727801.1\|2230295_2231582_+	DUF1577 domain-containing protein	NA	NA	NA	NA
WP_002727829.1\|2231683_2232895_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_002727805.1\|2233184_2233880_-	acireductone synthase	NA	NA	NA	NA
WP_002739187.1\|2235529_2236477_+	alpha/beta hydrolase	A7XCB7	Tanapox_virus	5.3e-25	31.1
WP_032853090.1\|2236587_2236839_-	hypothetical protein	NA	NA	NA	NA
WP_002739182.1\|2236856_2237330_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	S5VY82	Leptospira_phage	3.5e-54	61.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP012030

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP012029

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection