CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP012522	Enterococcus faecium strain 64/3 isolate human patient chromosome, complete genome	2 crisprs	cas3,DinG,cas2,cas14j,csa3,DEDDh	1	1	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012522_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012522_1

175896-176051

Orphan

Consensus_repeat	Method
AGAAAAACCAGATGTAACTCCAGAACCAGATACGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012522_1

>merge|NZ_CP012522|1|175896-176051|CRISPRCasFinder
AGAAAAACCAGAGGTAGCCCCAGAAGAAAAACCAGATGTAACTCCAGAACCAGATACGGATTCTGGAAACCAAACAGTACCGGAAACAAATCCAGACACAGATAATGAAACTGAAAATCCAGAAAAACCAGATGTGACTCCAGAACCAGATACGGA

>NZ_CP012522|1|1|175896-176051|CRISPRCasFinder
AGAAAAACCAGAGGTAGCCCCAGAAGAAAAACCAGA	TGTAACTCCAGAACCAGATACGGATTCTGGAAACCAAACAGTACCGGAAACAAATCCAGACACAGATAATGAAACTGAAAATCC
AGAAAAACCAGATGTGACTCCAGAACCAGATACGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012522.1\|WP_002288160.1\|180551_182318_+\|alpha-glycosidase	unknown	unknown	gnl\|CDD\|200477
NZ_CP012522.1\|WP_002288167.1\|176504_177584_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP012522.1\|WP_002288183.1\|162883_164920_+\|penicillin-binding-protein-4	unknown	unknown	gnl\|CDD\|223839
NZ_CP012522.1\|WP_002288181.1\|166333_166864_-\|membrane-protein	unknown	unknown	gnl\|CDD\|225786
NZ_CP012522.1\|WP_002288176.1\|169715_170378_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP012522.1\|WP_002296275.1\|172198_173281_+\|mannonate-dehydratase	unknown	unknown	gnl\|CDD\|235172
NZ_CP012522.1\|WP_002288156.1\|185129_185981_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226354
NZ_CP012522.1\|WP_002288178.1\|169008_169572_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|211789
NZ_CP012522.1\|WP_002288171.1\|173388_174942_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|368260
NZ_CP012522.1\|WP_002288163.1\|178189_178600_-\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NZ_CP012522.1\|WP_002288162.1\|178780_179215_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319910
NZ_CP012522.1\|WP_002288180.1\|166962_167313_-\|DUF2200-domain-containing-protein	unknown	unknown	gnl\|CDD\|337575
NZ_CP012522.1\|WP_002288157.1\|183825_185127_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP012522.1\|WP_060475214.1\|179314_180163_-\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_CP012522.1\|WP_002288179.1\|167469_168999_-\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942
NZ_CP012522.1\|WP_002295923.1\|185993_186809_+\|maltodextrose-utilization-protein-MalA	unknown	unknown	gnl\|CDD\|227808
NZ_CP012522.1\|WP_002295931.1\|165028_166180_-\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|273348
NZ_CP012522.1\|WP_002288165.1\|177692_178133_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP012522.1\|WP_002288159.1\|182419_183679_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270376
NZ_CP012522.1\|WP_044144738.1\|170561_172208_+\|mannitol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223324

Protein	Function_ID	Function_description	E-value
NZ_CP012522.1\|WP_002288160.1\|180551_182318_+\|alpha-glycosidase	gnl\|CDD\|200477	cd11338, AmyAc_CMD, Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins. Cyclomaltodextrinase (CDase; EC3.2.1.54), neopullulanase (NPase; EC 3.2.1.135), and maltogenic amylase (MA; EC 3.2.1.133) catalyze the hydrolysis of alpha-(1,4) glycosidic linkages on a number of substrates including cyclomaltodextrins (CDs), pullulan, and starch. These enzymes hydrolyze CDs and starch to maltose and pullulan to panose by cleavage of alpha-1,4 glycosidic bonds whereas alpha-amylases essentially lack activity on CDs and pullulan. They also catalyze transglycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules. Since these proteins are nearly indistinguishable from each other, they are referred to as cyclomaltodextrinases (CMDs). The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP012522.1\|WP_002288167.1\|176504_177584_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	4.82507e-33
NZ_CP012522.1\|WP_002288183.1\|162883_164920_+\|penicillin-binding-protein-4	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	4.2142e-100
NZ_CP012522.1\|WP_002288181.1\|166333_166864_-\|membrane-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	1.31275e-06
NZ_CP012522.1\|WP_002288176.1\|169715_170378_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.49257e-37
NZ_CP012522.1\|WP_002296275.1\|172198_173281_+\|mannonate-dehydratase	gnl\|CDD\|235172	PRK03906, PRK03906, mannonate dehydratase; Provisional.	0
NZ_CP012522.1\|WP_002288156.1\|185129_185981_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226354	COG3833, MalG, ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism].	8.93454e-123
NZ_CP012522.1\|WP_002288178.1\|169008_169572_-\|peroxiredoxin	gnl\|CDD\|211789	TIGR03137, AhpC, peroxiredoxin. This peroxiredoxin (AhpC, alkylhydroperoxide reductase subunit C) is one subunit of a two-subunit complex with subunit F(TIGR03140). Usually these are found as an apparent operon. The gene has been characterized in Bacteroides fragilis, where it is important in oxidative stress defense. This gene contains two invariant cysteine residues, one near the N-terminus and one near the C-terminus, each followed immediately by a proline residue. [Cellular processes, Detoxification, Cellular processes, Adaptations to atypical conditions].	1.29598e-129
NZ_CP012522.1\|WP_002288171.1\|173388_174942_-\|transcriptional-regulator	gnl\|CDD\|368260	pfam05043, Mga, Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins. This is presumably a DNA-binding domain.	6.4802e-06
NZ_CP012522.1\|WP_002288163.1\|178189_178600_-\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	7.67565e-57
NZ_CP012522.1\|WP_002288162.1\|178780_179215_-\|VOC-family-protein	gnl\|CDD\|319910	cd07246, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.01349e-31
NZ_CP012522.1\|WP_002288180.1\|166962_167313_-\|DUF2200-domain-containing-protein	gnl\|CDD\|337575	pfam09966, DUF2200, Uncharacterized protein conserved in bacteria (DUF2200). This domain, found in various hypothetical bacterial proteins, has no known function.	9.54844e-78
NZ_CP012522.1\|WP_002288157.1\|183825_185127_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.1412e-65
NZ_CP012522.1\|WP_060475214.1\|179314_180163_-\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	7.44669e-53
NZ_CP012522.1\|WP_002288179.1\|167469_168999_-\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0
NZ_CP012522.1\|WP_002295923.1\|185993_186809_+\|maltodextrose-utilization-protein-MalA	gnl\|CDD\|227808	COG5521, COG5521, Predicted integral membrane protein [Function unknown].	1.72478e-47
NZ_CP012522.1\|WP_002295931.1\|165028_166180_-\|sodium:proton-antiporter	gnl\|CDD\|273348	TIGR00932, Na+/H+_antiporter, transporter, monovalent cation:proton antiporter-2 (CPA2) family. [Transport and binding proteins, Cations and iron carrying compounds].	1.6035e-76
NZ_CP012522.1\|WP_002288165.1\|177692_178133_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.13347e-21
NZ_CP012522.1\|WP_002288159.1\|182419_183679_+\|extracellular-solute-binding-protein	gnl\|CDD\|270376	cd13658, PBP2_CMBP, The periplasmic binding component of ABC transport systems specific for cyclo/maltodextrin; possess the type 2 periplasmic binding fold. This group includes the periplasmic cyclo/maltodextrin-binding protein of Thermoactinomyces vulgaris ATP-binding cassette transporter and related proteins. Cyclodextrins are a family of compounds composed of glucose units connected by 1, 4 glycosidic linkages to form a series of oligosaccharide rings, and their cavity is hydrophibic which allows cyclodextrins to accomodate hydrophobic molecules/moieties in the cavity. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.84012e-157
NZ_CP012522.1\|WP_044144738.1\|170561_172208_+\|mannitol-dehydrogenase-family-protein	gnl\|CDD\|223324	COG0246, MtlD, Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism].	6.77524e-105

>NZ_CP012522.1|WP_002288171.1|173388_174942_-|transcriptional-regulator
MQTQEAIKTFLLKKKSNTKLDIFLFLSEHRFFITTQYLADHFHMSESNFLLYIKELEQDFERLNLTELHIDKQKPFLKLNFEGIDPAYCYYRLFGRYCNESVSYQILTSLFSCQTNSIISLSQQTNYSASYLYTKMKKINAFLALYGLSISFSNNGRKSFSGKEVQIQYAALDIYWNIFSSTATEFYDEDPQVVAFMMNTFFKKEVLDRLNSGMIDKLYFLLKICKENFPATSVKDVQKEFTEYEYIDFFIDPSVDILRPNLPICREQRILVNILARLSITKIESEETSLEQYKLLKKANVPHVLYSREMVESFCTVFDLFIPEKEKILYSLAFARNKLYNGFLNFNQPNTPLPTFMLYQEHSVLKEVQTAIEQFYMDFREQNQHLLPVILEKENVQWMVEDLVHLYDRYKKQPRIVIGVNYTRDFYISKDLIVKIEQIFSNESIKIQNDFMENCNIVISDCPLKQLPSHIKKIYILKGIITPEDWKKVIMRISEYIFELKEEALMDQSKKENQVTS
>NZ_CP012522.1|WP_002296275.1|172198_173281_+|mannonate-dehydratase
MEMTFRWYGSQEEKITLDEIRQIPAVKGIVGTLMDIPVGEVWPRERIKELKEEIESRGLTLKVIESVNVHDAIKIGLPSREQYIENYKQTIRNLAEYGIEVICYNFMPVFDWVKSDLDYRLEDGSSTLAFISDDIPDDPREIVARIEHSSNEFELPGWEPERLAHIKSLLEAYASVDEEKLRENFAYFLQSIIPTCEEVGVKMAVHPDDPPYSIFGLPRIVKNREDLDWLCRIVDSPYNGITLCTGSIAEDPENDVYGILAEFCQRDRIPFAHVRNIKFLANRDFYEAPHKSEYGSLDMYRILKTMYDNGFNGYIRPDHGRMIWNETGRPGYGLYDRALGAVYLNGLWEAIEKGNKSKDN
>NZ_CP012522.1|WP_044144738.1|170561_172208_+|mannitol-dehydrogenase-family-protein
MIDLNNWRNFIPELSQKEVEIPHFDRASLRENGQKNPVWIHFGGGNLYRGFHAEIAQRLADLGELSTGVIVCETFDEEIIERAYQDFDDLILEVVMPSSGEFVKRILAATADSLYCHPDCSEHFDKMIRHFENPSLQLVTFAITEKGYRLKDTNNKYIGPIAVDIKNGPKKPSHTMSILAALLYKRFLSGAWPIALVSTDNFSQNGSQLRTSLLTIAKEWQKEGYVQNTFIQYLSNEEIVAFPWTMIDRITPNPSLSVSKMLAKEGFSNMSIFQTAKGNNIAPFVNTEDIHYLIMEDHFPNGRPKFEKAGVFLTDRATVDKADTMKVTTCLNPLHTSLAIMGCLLGYRSIAEEMKDPDLSLLVSEIGYNEGLPVVESPGIIDPKIFLEEVITVRFSNPNIPDMPQRIATDTSQKVAIRYGETIKKYMEIEVKDPQTLVFIPLTLAAWLRYLIGIDDQGKPFIPSPDPLLTDFQHKLSDIQLGTQDTSHIHEKMAPTLSNKEIFGVDLYQAELGRKIEEMFIKMVAGPNAVRKTLQDYLQEHGGNLSWK
>NZ_CP012522.1|WP_002288176.1|169715_170378_-|GntR-family-transcriptional-regulator
MKSSLQSQAYQAIRKQIIYADLEPGRKISEKALEEHLAIGRTPIREALIQLRQQELVYTIPQSGTYVSKINLVSAENARFVREQLEEQIMIECCSKLDTQTRIVLETILEEQEKAVKINDERAFFRADNLFHEACFEIAGRKEVWNWLDDHNTHLERFRWLRVTIQGLPWETIMEQHYDLLKALVDKKPEEARFQTGLHLHMMLKEQETVTQRYPEYFQQ
>NZ_CP012522.1|WP_002288178.1|169008_169572_-|peroxiredoxin
MSLIGKKIEEFNAHAYHQGEFLEVSEKDLMGNWSILCFYPADFTFVCPTELEDLQEQYSTLKSLGVEVFSCSTDTHFTHKAWHDTSDAIGKIEYVMIGDPSHQISRIFDVLDEEQGLAQRGTFIIDPDGIVQAMEINADGIGRDASALIDKIRAAQYVRTHPGEVCPAKWKESGETLKPSFDLVGKI
>NZ_CP012522.1|WP_002288179.1|167469_168999_-|alkyl-hydroperoxide-reductase-subunit-F
MLDKETKQNLEQYLALIESPIVFSVSLDNSENSQKLAEFTKEIAEMSPKISWEKRDSMRTPSFSINPVGKESGIVFAGIPLGHEFSSFLLAMLQISGRAPKISESLSLKIKKITQTLHFDSYVSLTCHNCPDVVQALNILAVLNPNITHTMIEGGMFQKEIDDKKIMAVPTVFLNGEEFSSGRMTIEQIVEKITGPLIEEELFEKEPYDVLVIGGGPAASSAAIYAARKGIRTGLVADSFGGQVVETLGIENMIGTSYTEGPKLMQQVESHVRSYPIDIMMNQQAVSLNKEQHFINIGLANGISLKAKTAIIATGAHWRSINVPGEKEFKNKGIAYCPHCDGPLFKGKEIAVIGGGNSGVEAAIDLAGLAKHVYVLEFLPELKADQILQDKLVSLANVTVIKHAATKEISGTNQVESLSYIDRRTMEMHTLAVSGVFILVGLLPNTDWLDGTIEMNPRNEIVTEKNGATNIPGVFAAGDCTDSPYKQIIVSMGSGATAALGAFDYLMRT
>NZ_CP012522.1|WP_002288180.1|166962_167313_-|DUF2200-domain-containing-protein
MAQNRIFTTSFASVYPMYVAKAERKDRIKEEVDEIICWLTGYSQTELEYQLQKQVTFEQFFAEAPVPNPSRSLITGVVCGVRVEDIEDNLMKEIRYLDKMIDELAKGKKMEKILRS
>NZ_CP012522.1|WP_002288181.1|166333_166864_-|membrane-protein
MFETIKQNIQKYALLRAAVYIISGIAIVLNPSAVFHFIGYLITAYLVLLGLLNLFEAYRFKRKTGSWSIGLFSGLFFLILALIVYAFAPAIVSILPILLGLAVIINSLFQLFFSMNTKAKSWSVYSSILLLIGGFVLLFNPFKSLMLLFQIFGFILIFMGIQEIINFIRIRKMTIR
>NZ_CP012522.1|WP_002295931.1|165028_166180_-|sodium:proton-antiporter
MEFIGILCLILISTTIGSHISRRLGIPAVIGQLLVGVLLGQAGLNWVKPDILVHDFSEIGVILLMFLAGLESDLSLLKKYFRPGMFVALLGIIFPVVFGWLTGKAFQVSGNEAIFFGIILAATSVSISVEVLKELNVVNTKEGSTILGASVVDDILVVLVLSFSLSFLTGEASSNASLPLVLIEQLIYFVFIFLLVKWIAPFLLSFAEKVYANSSIIIVSLVICLGMSYVADLVGLSSVIGAFFAGIAVSQTKVKEEVYHNVEALGYAVFIPVFFVSVGLEVDFSDFSEQLLFISILTLVAILTKLLGGYFGAQIAGFSQHSSLMVGAGMISRGEMALIILQIGQQSQLIEPQYYSPLVIVILLSTLISPLVLKYFTKKVYEV
>NZ_CP012522.1|WP_002288183.1|162883_164920_+|penicillin-binding-protein-4
MKRSDKHGKNRTGAYIAGAVILIAAAGGGYFYYQHYQETQAVEAGEKTVEQFVQALNKGDYNKAAEMTSKKAANKSALSEKEILDKYQNIYGAADVKGLQISNLKVDKKDDSTYSFSYKAKMNTSLGELKDLSYKGTLDRNDGQTTINWQPNLVFPEMEGNDKVSLTTQEAARGNIIDRNGEPLATTGKLKQLGVVPSKLGDGGEKTANIKAIASSFDLTEDAINQAISQSWVQPDYFVPLKIIDGATPELPAGATIQEVDGRYYPLGEAAAQLIGYVGDITAEDIDKNPELSSNGKIGRSGLEMAFDKDLRGTTGGKLSITDADGVEKKVLIEHEVQNGKDIKLTIDAKAQKTAFDSLGGKAGSTVATTPKTGDLLALASSPSYDPNKMTNGISQEDYKAYEENPEQPFISRFATGYAPGSTFKMITAAIGLDNGTIDPNEVLTINGLKWQKDSSWGSYQVTRVSDVSQVDLKTALIYSDNIYMAQETLKMGEKKFRTGLDKFIFGEDLDLPISMNPAQISNEDSFNSDILLADTGYGQGELLINPIQQAAMYSVFANNGTLVYPKLIADKETKDKKNVIGETAVQTIVPDLREVVQDVNGTAHSLSALGIPLAAKTGTAEIKEKQDEKGKENSFLFAFNPDNQGYMMVSMLENKEDDDSATKRASELLQYLNQNYQ
>NZ_CP012522.1|WP_002288167.1|176504_177584_-|AI-2E-family-transporter
MNNVFIFCYLEVVDLTVYQRFLANEKIRRLTVLLFVVFVLFLVRSMITTILLTFIFTYLMIHLVQIIQRFVRIPTGVLAIMIYTLIVYLIYLAFTKYIPMLIHQTFDMIQSVIDFYEHQPKDADPVLQYIHTYIERNDFFEQLQNGASIALGYLQDIGKMAVAFAMSFILSFFFMIEKKKTIVFSRLFLKSEFSWFFQDIYYFADKFVNTFGLVLEAQFVIALLNTLLTTIALAVFGFHQLLSLAIMIFILSLIPVAGVIISCIPLSFIAYSQGGIRDVVYILITILIVHLIESYVLNPKLMSSKTELPIFYTFVVLLVSERFFGVWGLIVGIPIFTFFLDVLKVKKIPNHLPKETDIP
>NZ_CP012522.1|WP_002288165.1|177692_178133_-|MarR-family-transcriptional-regulator
MEDLYLVNQVCFPLYAASKEIIRHYTSLLKPLNLTYTQYLVMLVLWEKKKTSVKELGNDLCLDSGTLTPLLKKLAEKNYINRQRETGDERIVNVTLTPQGAALQKQAEGIPQKIKSYLPLEQEELDTLQHLTRKMLDNFHQDQKKG
>NZ_CP012522.1|WP_002288163.1|178189_178600_-|organic-hydroperoxide-resistance-protein
MKKMYSTKMINTGGRSGEVHNPDRTFELNIAAPGKRVENATNPEQLFAAGFSACFNSALELIKQQKNISGASTVSAQVSLYSESETSFVLGVEIEGSIEGLSLEETQELLEAAHKVCPYSKATAGNIEVTLKAVSE
>NZ_CP012522.1|WP_002288162.1|178780_179215_-|VOC-family-protein
MHKGTEIDFVLNDSLKALELYQTIFDEIQLIEATDYPRGNNEVIFTLYGTRFHMLDENTSLGLTAPTAEHPNTIWFNIIVSDIEDTHNKALRNGCVEIQEMTEMMDFGVTNSMFRDPFGYLWMLHQVHREVSFEERKQLFEKYM
>NZ_CP012522.1|WP_060475214.1|179314_180163_-|YitT-family-protein
MKETRQFIWTYIKIIFALFILGVAINMFLGPHHIAAGGVSGLGILLEAALGFDRAIVILVLNIVMLVLALLFLGKKPFFKVLFGSLFFPLIIAIVPETMITSDRLLSVIFGSAIFALGVAILYKNNSSSGGTTIPPLIFKKYFHLNTSIGLFFTDAFVVSLNLFVFGIEEFLYAILSIAITSIVMTYIETGINRKKSVMVMSEHYLEDIRLRLSAEIGRGLTLLEAKGGYNRKSKEVLLIVVTDHEFSRMKPLIEEIDPGAFVIVSSVAEVMGRGFTYHPIE
>NZ_CP012522.1|WP_002288160.1|180551_182318_+|alpha-glycosidase
MDTAAIYHRPESEYAFLYTNTRFRIRLRTRKNDIKKVYVLCGDPYTITTEKWYQKQRPMKKCLSTNVHDYWEIEVTSETRRLQYAFHVVGEDNTDCFYGDQGIFPYRENVITEPNFYFRIPYFHQIDRFTIPEWVKETVWYQIFPERFANGDKANDPEHTLPWGSKDPDREDFFGGDLQGVRDHLDYLTDLGVNGIYFCPIFKATSNHKYDTIDYYEVDPAFGDKKLLKNLIDEAHKRGIRIMFDAVFNHMGVHSPQWQDVLKNGEKSIYKDWFHIRFFPVDSYQMTDLPETAENIPYDTFAFTPFMPKLNTANPEVQKYLLDIATYWIKEFDIDGWRLDVANEVDHHFWKKFREAVTEIKPDIYILGEIWHSSQAWLQGDEFHAVMNYAFTDSIKDYFAKKKITASQMVSGMNHQQMLYRDQVNEGTFNLLDSHDTARILTLCQGNKELMKSVMAFMFLQKGSPCIYYGTEIGMTGEDDPDCRKCMIWEKEEQDLELFGFIKELVSLRKQLSKIISEGSTQWLIVYDREDKLYFTRELEGQIIYVYFNQSKEPWVVEQENEVILSQNCQLLEDGKAEIRQYGFLIMC
>NZ_CP012522.1|WP_002288159.1|182419_183679_+|extracellular-solute-binding-protein
MKKRSVKQLGLGLISLGILGGLAACGNGNSSAEGEADEGKTLTVSVDSGYKDYINEIKNTFEKENDVKIKLVEKDMFDQLESLALDGPAGKGPDVMMAAYDRIGALGQQGHLAEVKLGNEAAYDETDKAQVTYDGKIYGEPAVIETLVLYYNKDLVDTAPSTFKDLENLSKDSRFAFESEAGKNTGFLAKWTDFYYSYGLIAGYGGYVFGDDGTNPSDIGLNNAGAVEGISYATDWFKNVWPKGMQDIKSAGDFASQQFMSNKTAAIIDGPWQAQTYKENNINYGVAKIPTLNNGQPYQPFGGGKGWVVSNYAKNKDLSQKWLDYVTNQENQEKFFEMVNEIPANQQARETAKAKNDELTTAVIEQYETAQAMPNIPEMGEVWTGAENLMFDAASGSKTPKESADEAVKTISEAIEQKY
>NZ_CP012522.1|WP_002288157.1|183825_185127_+|sugar-ABC-transporter-permease
MQQDKTSNINEKKITLCSLIPGMGQFVNGQAFKGIVFFAIFVLFIGQMLLGGFHALVGLVTLGSIPMEDHSLFILIEGTLQFIITIIFLIFYGLNLLDAYRVAKMRQEGKKINRTMKEVIHNIGDEGFPYLLTLPAYLLMIFTIIFPVLVTLFTAFTNYDFNHIPPASLIDWVGAKNFFSIFFLSSYRNTFFAVFSWTVIWTLCATTLQITLGILTAVVAHQKFIKFKRIFGIIFLLPWAVPAFITIMSFSNIFNDSVGAINTQVIPFINQLPFVDISAISWKTDPNWTKVAIILVQGWLGFPYIYVMVTGILQSISEDLYEAAKIDGANAWQRFSNITLPAVFLVAAPTFITQYTGNFNNFSMIYLFNNGGPGSVGGGAGSTDILISWIYKLTTGTSPQYSMASAITLIISVIVICVSLLVFKKTNAFNMGD
>NZ_CP012522.1|WP_002288156.1|185129_185981_+|sugar-ABC-transporter-permease
MKKFHSSARFQKRLSHFFTYFFLLILSVIIIYPLLITASTAFKSGNIAAFSLDLSSDWTLGNFTRLFSETLYGTWYKNTLIISVLTMIVQVTVVTLAGYTYSRYRFIGRKSSLMFFLVIQMVPTMAALTAFYVMAFLLEALDKYWFLTMIYIGGGIPMNTWLMKGYFDTVPIDLDESAKLDGAGHFRIFFQIVLPLVKPMLAVQALWAFMGPFGDFMLAKFLLRTPENQTVAVGLQTFISDVTNQRVSLFAAGAILIALPICLLFFFLQKNFVTGLTSGGTKG
>NZ_CP012522.1|WP_002295923.1|185993_186809_+|maltodextrose-utilization-protein-MalA
MQTFPLNYFSALRTPTQVFAGRKLLSWPKFFLIFVFLVSLMVMPVTLFYANQIQAIPLEQFLSVHSLIDEQGTQKFSELELSETGLQASQQTIAVTPEILVGVSLSEKQQSDHGTFIDFEKEQWVIQQKDKSGIRRYTMNYSPSFQPDSVRTPEDFQRFLEREFYASNRPTIILSYSLSLGLVLFVMTSLILFGASFFLWMTRKSQLSSIHTFKESANLMLNVMGIGSMAAAVVGFIHFDFILMLSVQTTITVLLLLWVFVKTRFKDKRVE

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Crispr_ID: NZ_CP012522_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012522_2

1100713-1100822

Orphan

Consensus_repeat	Method
CTTTGCTCAACCAGTATTATTCATCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012522_2

>merge|NZ_CP012522|2|1100713-1100822|CRISPRCasFinder
CTTTGCTCAACCAGTATTATTCATCACCTATTCACTTCGTTCATAGTGATTCTACTCGCTTTGCTCGAAAGGAAACTCCTTTCGCTTTGCTCAACCAGTATTGTTCATCA

>NZ_CP012522|2|2|1100713-1100822|CRISPRCasFinder
CTTTGCTCAACCAGTATTATTCATCA	CCTATTCACTTCGTTCATAGTGATTCTACTCGCTTTGCTCGAAAGGAAACTCCTTTCG
CTTTGCTCAACCAGTATTGTTCATCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012522.1\|WP_002291638.1\|1101842_1102265_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_CP012522.1\|WP_002294588.1\|1099715_1100084_-\|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl\|CDD\|234671
NZ_CP012522.1\|WP_002294593.1\|1092563_1093703_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP012522.1\|WP_002294580.1\|1106407_1106953_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP012522.1\|WP_002287792.1\|1091509_1092475_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|275027
NZ_CP012522.1\|WP_002294577.1\|1107561_1108206_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341358
NZ_CP012522.1\|WP_002294585.1\|1102607_1103276_+\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	unknown	unknown	gnl\|CDD\|224674
NZ_CP012522.1\|WP_002291634.1\|1100136_1100640_-\|50S-ribosomal-protein-L10	unknown	unknown	gnl\|CDD\|234632
NZ_CP012522.1\|WP_002303471.1\|1097636_1098839_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_CP012522.1\|WP_002287793.1\|1089300_1091460_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|180921
NZ_CP012522.1\|WP_002294581.1\|1105443_1106331_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|283645
NZ_CP012522.1\|WP_002294587.1\|1101049_1101739_-\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071
NZ_CP012522.1\|WP_002294589.1\|1098920_1099610_-\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NZ_CP012522.1\|WP_060672675.1\|1103288_1104161_+\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	unknown	unknown	gnl\|CDD\|129801
NZ_CP012522.1\|WP_002287788.1\|1094011_1094725_-\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NZ_CP012522.1\|WP_002287787.1\|1094978_1095680_-\|glucosamine-6-phosphate-deaminase	unknown	unknown	gnl\|CDD\|238693
NZ_CP012522.1\|WP_002290558.1\|1095913_1097446_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP012522.1\|WP_002294578.1\|1107247_1107400_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_CP012522.1\|WP_002294583.1\|1104251_1105271_-\|L-lactate-oxidase	unknown	unknown	gnl\|CDD\|240088
NZ_CP012522.1\|WP_002294579.1\|1107053_1107224_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|376355

Protein	Function_ID	Function_description	E-value
NZ_CP012522.1\|WP_002291638.1\|1101842_1102265_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	9.059e-96
NZ_CP012522.1\|WP_002294588.1\|1099715_1100084_-\|50S-ribosomal-protein-L7/L12	gnl\|CDD\|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	5.30333e-45
NZ_CP012522.1\|WP_002294593.1\|1092563_1093703_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	2.46227e-61
NZ_CP012522.1\|WP_002294580.1\|1106407_1106953_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	1.97252e-86
NZ_CP012522.1\|WP_002287792.1\|1091509_1092475_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	gnl\|CDD\|275027	TIGR04171, ribonucleotide-diphosphate_reductase_subunit_beta, ribonucleoside-diphosphate reductase, class 1b, beta subunit. Members of this family are NrdF, the beta subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	0
NZ_CP012522.1\|WP_002294577.1\|1107561_1108206_+\|CBS-domain-containing-protein	gnl\|CDD\|341358	cd02205, CBS_pair_SF, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	5.69774e-14
NZ_CP012522.1\|WP_002294585.1\|1102607_1103276_+\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	gnl\|CDD\|224674	COG1760, SdaA, L-serine deaminase [Amino acid transport and metabolism].	1.41351e-73
NZ_CP012522.1\|WP_002291634.1\|1100136_1100640_-\|50S-ribosomal-protein-L10	gnl\|CDD\|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	3.03735e-67
NZ_CP012522.1\|WP_002303471.1\|1097636_1098839_-\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.7222e-69
NZ_CP012522.1\|WP_002287793.1\|1089300_1091460_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|180921	PRK07306, PRK07306, ribonucleotide-diphosphate reductase subunit alpha; Validated.	0
NZ_CP012522.1\|WP_002294581.1\|1105443_1106331_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|283645	pfam06028, DUF915, Alpha/beta hydrolase of unknown function (DUF915). This family consists of several bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	4.81944e-80
NZ_CP012522.1\|WP_002294587.1\|1101049_1101739_-\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	1.66496e-146
NZ_CP012522.1\|WP_002294589.1\|1098920_1099610_-\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	3.65546e-19
NZ_CP012522.1\|WP_060672675.1\|1103288_1104161_+\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	gnl\|CDD\|129801	TIGR00718, Probable_L-serine_dehydratase_alpha_chain, L-serine dehydratase, iron-sulfur-dependent, alpha subunit. This enzyme is also called serine deaminase. L-serine dehydratase converts serine into pyruvate in the gluconeogenesis pathway from serine. This model describes the alpha chain of an iron-sulfur-dependent L-serine dehydratase, found in Bacillus subtilis. A fairly deep split in a UPGMA tree separates members of this family of alpha chains from the homologous region of single chain forms such as found in Escherichia coli. This family of enzymes is not homologous to the pyridoxal phosphate-dependent threonine deaminases and eukaryotic serine deaminases. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	5.05695e-103
NZ_CP012522.1\|WP_002287788.1\|1094011_1094725_-\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	6.15701e-49
NZ_CP012522.1\|WP_002287787.1\|1094978_1095680_-\|glucosamine-6-phosphate-deaminase	gnl\|CDD\|238693	cd01399, GlcN6P_deaminase, GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.	8.8122e-119
NZ_CP012522.1\|WP_002290558.1\|1095913_1097446_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	5.56109e-170
NZ_CP012522.1\|WP_002294578.1\|1107247_1107400_-\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	3.12722e-17
NZ_CP012522.1\|WP_002294583.1\|1104251_1105271_-\|L-lactate-oxidase	gnl\|CDD\|240088	cd04737, LOX_like_FMN, L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate dehydrogenase (MDH), and long chain hydroxyacid oxidase (LCHAO).	0
NZ_CP012522.1\|WP_002294579.1\|1107053_1107224_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|376355	pfam00584, SecE, SecE/Sec61-gamma subunits of protein translocation complex. SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.	1.48e-13

>NZ_CP012522.1|WP_002291634.1|1100136_1100640_-|50S-ribosomal-protein-L10
MSEAIIAKKAAIVDEVSEKFTAAASVVVVDYRGLTVDEVTRLRKQLRDANVEMKVIKNSILSRAAKKAGLEGMDEVFTGPTAVAFSNEDVVAPAKIMDEFAKEAKALEIKGGIIEGKVSSLEEITALAKLPNREGLLSMLLSVLQAPVRNVAYAVKAVADKEDGDAA
>NZ_CP012522.1|WP_002294588.1|1099715_1100084_-|50S-ribosomal-protein-L7/L12
MALNIENIVAELKEATILELNDLVKAIEEEFGVSAAAPVAVAAAGGAAAAEEQTEFTVELTAAGDQKVKVIKAVREATGLGLKEAKAVVDGAPAPVKEGVSKEEAEELKAKLEEVGASVTVK
>NZ_CP012522.1|WP_002294589.1|1098920_1099610_-|TVP38/TMEM64-family-protein
MKKKIIRLILISLGIILILVVGYRLYLEYQTDIQLFLNPRASKAELLAHIRSHGTFASILLIVLTAVMCAVPGIPTSVVGVIAGLSFGPLTGAIINILGNALGNITAIFLMHRLKFLDKKTETNHWVQAIRQMKHPKIGVMLGYMIPVIPSSMVNFAADAMKLPLQQIILSIVIGVIPSSVLYACGGEALFHGYNKTAVTLVASVTVLVGLVVFIYKDRKKKQGKQKHK
>NZ_CP012522.1|WP_002303471.1|1097636_1098839_-|MFS-transporter
MKSNEKKPLTTSLILLLSITCGVVVANMYYIQPIGTKVAASLSVSTSAVGILTMLTQLGYALGLLFLVPLGDVVDRPKLIIRMAALSAVSLLAAFFAPSFTLFACASFLIGLLSIVPQIIIPYGAVLAGPKARGKVMGTLLSGLLVGILLSRTVSGIVASLFSWRMIYLFALCAVGILTLLLYWKMPRSVQQSSTAVSYLDSLKSLPHLVASQRLLREAAVSGFFMFGTFSIFWSTLIFYISSPAYNWGTFEAGILAIFGLSGAVAAPIVGRLADSYSERKIVYMGLVMQTISFIALLVGGSHLAILLLAIILLDVGNQFGQVANQTRVQGLGEAASNRNNTVFMFMYFIGGAAGSLLGTTMWQQYGWLGVTVSGLVFQGCAFFFQTVVFKGKRNLENKK
>NZ_CP012522.1|WP_002290558.1|1095913_1097446_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSILTLNNITQQFGDKILYEGVDLQLNAGEHLGLIGQNGAGKSTLIKIITGEILPDDGQIHWQKNIHKGYLDQYVEVDETLTIEEFLKTAYAKEYEKEEKIAFLYQTYSETFDDSLLEKAGKLQTELDQGVFYQIDTLVAEMSSGLGIDVLGLDSLLKNLSGGQRSKVILAKLLLENPDVLILDEPTNHLDDQHIQWLTQFLQDFDGAYIVISHDQEFLDQITTHIADIEFGKITKYTGHLKQALKQKEQNRESYLRQYHAQQKQIEKTEAYIRKYKAGSRSTMAKSRQKQLDKIERLTPPASASKAVFDFPFSPIVTTLAVETTDLVIGYDRPLLAPINLTIRFGENIAIRGFNGIGKSTLLKTLIGEIEKISGDFHFPDNTKINYFSQDLYWENPLETPLQYLSSQFPKATIKELRRQLAKAGLVNQLASEPLTTLSGGEQTKVKLAQLTMNQGNLLILDEPTNHIDQETKESLQDGIQKFPGTVIIVSHEQEFYQDLVQRVIEIEPK
>NZ_CP012522.1|WP_002287787.1|1094978_1095680_-|glucosamine-6-phosphate-deaminase
MEIIRVKNAEEGGKKAFEIIKEGMNKGAKVLGLATGSTPVTLYKEMTSSDLDFSEMTSVNLDEYVGLGGSDEQSYRHFMDVQLFDKKPFKETFVPDGKAEDLEAACKKYDQIIDAHPIDIQILGIGQNGHIGFNEPGASFDGTTSVVDLTESTINANKRFFDKAEDVPTKAVSMGIGSIMKSKEIVLMAFGESKADAIKGMIEGPVTNHLPASVLQNHDNVVVIIDEEAASKL
>NZ_CP012522.1|WP_002287788.1|1094011_1094725_-|MgtC/SapB-family-protein
MNDMVLTIPEIILRLGIAMLFGGAIGFERQYKNRPAGMRTHILVCMGACIIALIQVEIASGALRDALEYPQLAGTIRSDEARLIAQVVSGVGFLGAGTIIVTKQSVTGLTTAASLWAIAGLGIAIGMGYYSIAIISFIGIAIALTVVKRVIHVPTTKKLEIQFIHRKETKDFLTDYFEEKNIVIEDVNFDVKFVDDYRVYKNIYTIDLPKGLTYADVIEELSVHKNITKLHLVSIAQ
>NZ_CP012522.1|WP_002294593.1|1092563_1093703_-|AI-2E-family-transporter
MQSRFKQSKLFFWTVELVLTIIGVYFILQMPNIFSPILKMLSAVFLPLLVAGFIYYMFDPIVVFLEKHRIPRVFGFLLTFLVVIILVVLTVMNVVPQLMEQTIQLTQSLPMYADETSKWLNELAQREEFKNFNLEEQLASANLSLSNLFNIILVSLSASVSKIISFMMQFFILLFTVPFILLFMFKDGHKFIDALSHFFPKAIRKELRQTVKELNETLSAYISSTILDALIIGVMSFLAMRIFDQPYSLLLAVICGITNIIPYVGPFIGAVPAIIVGLFISPFQALYMALSILVIQQLDGNLIKPLLFGKSMNIHPLTIILVLIGAGSVAGILGMLICIPVYAVIKTIILNIRKIYLLRRMEHVSEKLDSPKVLEETSE
>NZ_CP012522.1|WP_002287792.1|1091509_1092475_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta
MSETYYEAINWNEIEDIIDKSTWEKLTEQFWLDTRIPLSNDLDDWRTLSQLEKDTVGHVFGGLTLLDTVQSESGMDQLRKDVRTPHEEAVLNNIQFMESVHAKSYSSIFSTLNTKKEIEEIFDWTNTNPYLQKKAERINEIYKHGTPLEKKIASVFLETFLFYSGFYTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLGFNELPEAEQETLKDWMYNLLYELYENEERYTEELYDPIGWTEEVKTFLRYNANKALMNLGMDPLFPDTANDVNPIVMNGISTGTSNHDFFSQVGNGYLLGHVEAMKDDDYLIGLE
>NZ_CP012522.1|WP_002287793.1|1089300_1091460_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha
MSLKNLQDVSYFKLNNEINRPVNGQIPLNKDKEALVAFFEENVKPNTMTFPSIMEKINYLIDQEYIEAEFIQLYSPSFIEKLYQFLDEQHFSFKSFMAAYKFYSQYALKTNDGSAYLETYEDRVAFNALYFANGDEELALALADEMIHQRYQPATPSFLNAGRKRRGELVSCFLTQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYEGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIIAFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRKNEDMYLFSPYSVEKEYGVPFSYVNITAEYDHLVANPNIRKQKIKARDLENEISKLQQESGYPYVINIDTANRENPIDGKIIMSNLCSEILQVQTPSVINGKQEYEVLGTDISCNLGSTNIVNLMQSPNFGQSVRTMTRALTFITDASDIDVVPPIQNGNKLNHTIGLGAMGLHTYLAKEQMEYGSEDSLDFTNIYFMLLNYWTLVESNNIARERKQVFHNFEKSAYADGTYFEKYVTGEFQPKSEKVKALFEGIFIPTAEDWNALKQAVMKDGLYHQNRLAVAPNGSISYINDTSASIHPITRMIEERQEKKIGKIYYPAPYLSNETIPYYTSAYDMDMRKVIDVYATAQQHVDQGMSLTLFMRSEIPEGIYEWKTTTKQTTRDLNILRHYAFHKGIKSIYYVRTFTDDAEEIGSNQCESCVI
>NZ_CP012522.1|WP_002294587.1|1101049_1101739_-|50S-ribosomal-protein-L1
MAKKSKKMQDALKKVDSSKVYPVAEAVALAKETNIAKFDATVEVAYRLNVDPKKADQQIRGAVVLPNGTGKTQTVLVFAKGDKAKEAEAAGADFVGDDDMVQKIQNGWFDFDVVVATPDMMATVGRLGRVLGPKGLMPNPKTGTVTMDVTKAVNEVKAGKVTYRVDKAGNIHVPIGKVSFDDEKLVENFAAIHDVLLKAKPSAAKGQYMKNVTITTTFGPGIHVDQASF
>NZ_CP012522.1|WP_002291638.1|1101842_1102265_-|50S-ribosomal-protein-L11
MAKKVEKIVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNARTADQAGLIIPVVISVYEDRSFTFVTKTPPAAVLLKKAAKIEKGSGEPNKNKVAKVSSDQVREIAELKMEDLNAANVEAAMRMVEGTARSMGITVE
>NZ_CP012522.1|WP_002294585.1|1102607_1103276_+|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta
MKDLRYRSVFDIIGPVMIGPSSSHTAGAARIGKIIRSIFGEQPDSVDIYLYESFAKTYRGHGTDIALVGGLLGMEPDDERLADSLKLAYEAGMEVLFVPKSEKAEHPNSVKMLLKKGTRKLSVTGISIGGGNIQISELNGFKISLSMGTPTLIVVHQDVPGMIAKVTSILSETNTNIGTMTVTRESKGENAIMIIEVDDPQVEETVKRLKQLPNIDSVNYFD
>NZ_CP012522.1|WP_060672675.1|1103288_1104161_+|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha
MFLSIEELVDQAKAYPSVAELMIAVEMEMSGRSRSHIIEIMEKNLSVMEQSINEGKEGVTSVTGITGGDAKKLDDYLNEADFLSGETILKAVRNAVAVNEVNAKMGLICATPTAGSAGVVPGVLMAVRDRLDLTYEQQLEFLFTAGAFGLVIANNASISGAEGGCQAEVGSASAMAAAALVCAKNGTPHQAAQAVAITLKNMMGLICDPVAGLVEVPCVKRNALGSSQAFISADMALAGIESVIPPDEVVAAMYQVGRQMPSIFKETAEGGLAVTPTAKRLAEEILNKRA
>NZ_CP012522.1|WP_002294583.1|1104251_1105271_-|L-lactate-oxidase
MEAGAFGYIRGGSEDEWTMKENTTSFNTKKIMPRILRGIDSADLHTSVFGIELDTPIIQAPSAAQGLAHEKGEADTAKGVAAAGSIFSISTYANTTIKDAADAAPGAPQFFQLYMSKDDRFNEFILNKAVEAGAKAIILTADSTLGGYREEDVINQFQFPLPMPNLAAYSEQSASGNGEGKGIAEIYAAAKQGLTPDDIKTIKEITHLPVIVKGIQSPEDAVIAISAGADGIWVSNHGGRQLDGGPASFEVLPKIAEVVNKRVPVIFDSGVRRGEHVFKALASGADLVAIGRPVIYGLNLGGAEGVTSVFEHLNKELSITMQLAGTKTIDEVKNTKLMD
>NZ_CP012522.1|WP_002294581.1|1105443_1106331_-|alpha/beta-fold-hydrolase
MTEPIKNLCKRATAAALVLISLFALSGCQTTKINTTEVSDKEKTAESSKVIEKTTIPTLFFHGYSGTENSFKGMLRRLEKNQQAVKELVLTVGTDGQIQATGDLSGKADNPMVQVLFEDNKNNEWNQAEWIKTCLLYLKENYGIDKVNIVGHSMGGVSALRYLGTYGQDTSLPQVQTLTAIGAPFNDFVDDSAQSLTDELAKGPAVVSNRYQDYQQMIGNIPITTRFFLIAGQLDETDLSDGTVPLNSALAVYALLKQRGNEIEEKVVTGENASHSMLHENQEVDQLVSRFIWKE
>NZ_CP012522.1|WP_002294580.1|1106407_1106953_-|transcription-termination/antitermination-protein-NusG
MESFEKNWYVLHTYSGYENKVKANIESRAQSMKMADFIFRVVVPEEKETEVKNGKEKEIVHKTFPGYVLVEMIMTDASWYVVRNTPGVTGFVGSHGAGSKPAPLLPEEVNHILRSIGMSLRQNDLEVEVGEVVKIIEGAFAGLEGQVTEVDGEKEKLKVNIDMFGRETSTELDFDQVDKID
>NZ_CP012522.1|WP_002294579.1|1107053_1107224_-|preprotein-translocase-subunit-SecE
MKFLKSVKDEIKQVTWPSRKQLRKDTLVVIETSIIFGLMFYVMDTAIQSLFGWILK
>NZ_CP012522.1|WP_002294578.1|1107247_1107400_-|50S-ribosomal-protein-L33
MAKKKAALACSVCGSRNYTKSVSEGKSGERLEINKFCKYCNQYTLHKETK
>NZ_CP012522.1|WP_002294577.1|1107561_1108206_+|CBS-domain-containing-protein
MLLKTLVYKKKDLTTVTETSTLEEALKILETSGYRCVPILDSSGNIFRGNIYKMHIYRHKANGGDMTLPVTHLLKNATKFIYLDTSFFKVFFTIKELPYIAVLDSENHFYGILTHSTLLNMLSQSWSVEQGSYVLTIASTGKQGDLAAIAKIISKHSSIASCITLDIEKDEYIRRTLITLPANTEAKVCETIVNHLEKKNYKVVEIENLQNQEA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP012522_1	1.1\|175932\|84\|NZ_CP012522\|CRISPRCasFinder	175932-176015	84	NZ_CP012522.1	175812-175895	25	0.702

1. spacer 1.1|175932|84|NZ_CP012522|CRISPRCasFinder matches to position: 175812-175895, mismatch: 25, identity: 0.702

tgtaactccagaaccagatacggattctggaaaccaaacagtaccggaaacaaatccaga	CRISPR spacer
tgtgactccagaaccagatacggattctggaaaccaaacagtaccggaaacaaatccaga	Protospacer
***.********************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012522_1	1.1\|175932\|84\|NZ_CP012522\|CRISPRCasFinder	175932-176015	84	NZ_CP019972	Enterococcus faecium isolate 2014-VREF-114 plasmid p114-2 sequence	63011-63094	24	0.714

1. spacer 1.1|175932|84|NZ_CP012522|CRISPRCasFinder matches to NZ_CP019972 (Enterococcus faecium isolate 2014-VREF-114 plasmid p114-2 sequence) position: , mismatch: 24, identity: 0.714

tgtaactccagaaccagatacggattctggaaaccaaacagtaccggaaacaaatccaga	CRISPR spacer
tgtaactccagaaccagatacggattctggaaaccaaacagtaccggaaacaaatccaga	Protospacer
************************************************************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

44807 : 91436

Enterococcus_phage(30.0%)

tRNA,protease,capsid,terminase,transposase,portal,integrase,tail

attL 39569:39583|attR 72578:72592

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
39569:39583	attL	NA	NA	NA	NA
WP_002300656.1\|44807_45509_+\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_002288338.1\|45505_46627_+	Nif3-like dinuclear metal center hexameric protein	NA	NA	NA	NA
WP_002288340.1\|46641_47874_+	peptidase T	NA	NA	NA	NA
WP_002300651.1\|48005_48914_+	YegS/Rv2252/BmrU family lipid kinase	NA	NA	NA	NA
WP_002330119.1\|48948_49221_+	DUF1294 domain-containing protein	NA	NA	NA	NA
WP_002300648.1\|49231_50278_+	flippase-like domain-containing protein	NA	NA	NA	NA
WP_002322596.1\|50293_51718_-\|transposase	IS1182-like element ISEfa12 family transposase	A0A1X9I5T2	Streptococcus_phage	4.4e-124	48.7
WP_002301554.1\|52067_54677_+	ATP-dependent chaperone ClpB	A0A2I7SAX5	Vibrio_phage	1.6e-132	35.0
WP_002301555.1\|54823_55495_-	hypothetical protein	NA	NA	NA	NA
WP_002301556.1\|55487_55982_-	nucleoside 2-deoxyribosyltransferase	A0A1W6JK28	Lactococcus_phage	3.2e-42	56.5
WP_002301557.1\|56001_57222_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_002334197.1\|57368_59204_+	elongation factor 4	E4ZFJ7	Streptococcus_phage	1.5e-20	24.6
WP_002334198.1\|59296_60433_-\|integrase	site-specific integrase	A0A2I7SCV1	Paenibacillus_phage	1.9e-114	54.5
WP_002309070.1\|60610_61480_-	hypothetical protein	NA	NA	NA	NA
WP_002330975.1\|61602_62169_-	DUF5067 domain-containing protein	NA	NA	NA	NA
WP_002331680.1\|62233_62662_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_002301565.1\|62668_63040_-	helix-turn-helix transcriptional regulator	O03970	Lactobacillus_phage	2.1e-22	45.2
WP_002301566.1\|63194_63428_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_002334201.1\|63640_64186_+	hypothetical protein	NA	NA	NA	NA
WP_060475437.1\|64191_64470_+	hypothetical protein	NA	NA	NA	NA
WP_002319163.1\|64466_64652_+	hypothetical protein	NA	NA	NA	NA
WP_002334202.1\|64788_65730_+	hypothetical protein	D2IZK1	Enterococcus_phage	5.6e-144	77.6
WP_002334203.1\|65731_66622_+	DNA recombination protein RecT	D2IYT9	Enterococcus_phage	3.7e-137	84.5
WP_002334204.1\|66670_67561_+	DnaD domain protein	NA	NA	NA	NA
WP_002334205.1\|67553_67913_+	DUF1064 domain-containing protein	A0A1P8BKR1	Lactococcus_phage	8.9e-18	46.6
WP_002296606.1\|67927_68089_+	antitoxin	NA	NA	NA	NA
WP_080375520.1\|68085_68397_+	hypothetical protein	NA	NA	NA	NA
WP_002326231.1\|68390_68681_+	hypothetical protein	D2IZR3	Enterococcus_phage	1.1e-13	43.4
WP_002311632.1\|68680_68992_+	hypothetical protein	A0A0D3MVS9	Staphylococcus_phage	7.0e-27	57.0
WP_002311630.1\|68988_69375_+	hypothetical protein	A0A060ABA9	Staphylococcus_phage	2.1e-12	35.5
WP_002325355.1\|69375_69837_+	class I SAM-dependent methyltransferase	D2IZK8	Enterococcus_phage	3.3e-73	78.3
WP_002311628.1\|69858_70236_-	hypothetical protein	NA	NA	NA	NA
WP_002311627.1\|70355_70565_+	hypothetical protein	NA	NA	NA	NA
WP_002311626.1\|70561_70924_+	hypothetical protein	NA	NA	NA	NA
WP_002325356.1\|70920_71154_+	DUF3850 domain-containing protein	C9E2N9	Enterococcus_phage	2.3e-22	71.2
WP_002325357.1\|71154_71514_+	hypothetical protein	NA	NA	NA	NA
WP_002325358.1\|71728_71932_+	hypothetical protein	NA	NA	NA	NA
WP_002325359.1\|71928_72225_+	hypothetical protein	NA	NA	NA	NA
WP_002304479.1\|72300_72714_+	autolysin	C9E2P5	Enterococcus_phage	1.1e-56	81.0
72578:72592	attR	NA	NA	NA	NA
WP_025478012.1\|72953_73190_+	hypothetical protein	NA	NA	NA	NA
WP_002325361.1\|73213_73426_+	hypothetical protein	A0A182BQC3	Lactococcus_phage	2.3e-13	55.9
WP_060475247.1\|73882_74077_+	hypothetical protein	NA	NA	NA	NA
WP_086956687.1\|74182_75345_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	1.6e-79	51.3
WP_002305386.1\|75677_76022_+	HNH endonuclease	A0A1B1P757	Bacillus_phage	1.0e-26	58.1
WP_002296599.1\|76026_76308_+	hypothetical protein	NA	NA	NA	NA
WP_002325363.1\|76410_76725_+	hypothetical protein	A0A1S7FYW6	Listeria_phage	3.3e-08	37.9
WP_002325364.1\|76702_78394_+\|terminase	terminase large subunit	A0A1B1P766	Bacillus_phage	1.8e-148	49.4
WP_002325365.1\|78413_79592_+\|portal	phage portal protein	A0A1B1P754	Bacillus_phage	5.4e-80	40.2
WP_002325366.1\|79554_80241_+\|protease	Clp protease ClpP	A0A2I6PDD0	Staphylococcus_phage	6.1e-31	40.2
WP_002325367.1\|80240_81401_+\|capsid	phage major capsid protein	A0A1B1P752	Bacillus_phage	3.6e-100	50.4
WP_060475245.1\|81410_82286_+	hypothetical protein	D2IYX3	Enterococcus_phage	2.1e-129	74.2
WP_060475243.1\|82282_82594_+	hypothetical protein	A0A1B1P751	Bacillus_phage	2.4e-11	43.5
WP_060475241.1\|82583_82937_+	hypothetical protein	NA	NA	NA	NA
WP_060475239.1\|82926_83328_+	hypothetical protein	A0A1B1P759	Bacillus_phage	3.9e-14	34.1
WP_002319774.1\|83320_83725_+	hypothetical protein	R4IBU7	Listeria_phage	6.1e-07	29.5
WP_002318244.1\|83736_84342_+	hypothetical protein	Q8W5Z9	Listeria_phage	6.7e-34	41.2
WP_002286510.1\|84363_84726_+	hypothetical protein	NA	NA	NA	NA
WP_002305377.1\|84728_84911_+	hypothetical protein	NA	NA	NA	NA
WP_060475236.1\|84927_88347_+\|tail	phage tail tape measure protein	A0A1D3SNL5	Enterococcus_phage	8.7e-78	41.5
WP_010729125.1\|88397_89135_+\|tail	phage tail protein	NA	NA	NA	NA
WP_060475234.1\|89144_91436_+	hypothetical protein	A0A1D3SNL1	Enterococcus_phage	3.0e-90	30.0

DBSCAN-SWA_2

406554 : 415615

Synechococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002288010.1\|406554_407133_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.3e-26	37.4
WP_060475435.1\|407129_408173_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	3.5e-62	43.7
WP_002288013.1\|408204_409644_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.3e-53	33.1
WP_002288015.1\|409628_411851_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.9e-150	41.3
WP_002288017.1\|411851_412523_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_002295474.1\|412524_412779_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_002288021.1\|412778_413507_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	E3SPA9	Prochlorococcus_phage	4.6e-45	41.4
WP_002297115.1\|413762_414140_+	hypothetical protein	NA	NA	NA	NA
WP_002288023.1\|414319_415615_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	4.5e-19	33.1

DBSCAN-SWA_3

821996 : 830468

Streptococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002288083.1\|821996_824186_+	anaerobic ribonucleoside-triphosphate reductase	A0A0C5KKX3	Enterococcus_phage	1.8e-286	66.6
WP_002288081.1\|824500_825103_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A288TZV3	Enterococcus_phage	1.7e-53	58.6
WP_002294035.1\|825156_826278_-	DNA polymerase IV	NA	NA	NA	NA
WP_002288078.1\|826386_827259_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	3.1e-88	60.4
WP_002288076.1\|827327_827675_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	5.1e-18	41.1
WP_002288073.1\|827667_828492_-	stage 0 sporulation family protein	NA	NA	NA	NA
WP_002288071.1\|828527_829466_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	3.3e-35	34.4
WP_002292340.1\|829479_829809_-	hypothetical protein	NA	NA	NA	NA
WP_002294039.1\|829823_830468_-	dTMP kinase	M1PSC7	Streptococcus_phage	4.2e-58	52.6

DBSCAN-SWA_4

2310969 : 2420963

118

Enterococcus_phage(36.0%)

tRNA,protease,capsid,terminase,holin,plate,transposase,portal,head,integrase,tail

attL 2338214:2338229|attR 2424054:2424075

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002288767.1\|2310969_2312268_+\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	1.2e-59	30.3
WP_002301946.1\|2313443_2314118_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_002319756.1\|2314114_2314456_+	hypothetical protein	NA	NA	NA	NA
WP_002288776.1\|2314485_2314845_+	YccF domain-containing protein	NA	NA	NA	NA
WP_002301949.1\|2315369_2317451_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	8.3e-116	35.7
WP_002288779.1\|2317761_2319228_+	amino acid permease	NA	NA	NA	NA
WP_002289037.1\|2319842_2320382_+	transcriptional regulator	A0A097BYE2	Leuconostoc_phage	3.8e-20	34.5
WP_002294855.1\|2320455_2320896_+	CopY/TcrY family copper transport repressor	NA	NA	NA	NA
WP_002289040.1\|2320908_2321118_+	copper chaperone CopZ	NA	NA	NA	NA
WP_060475337.1\|2321117_2323304_+	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	6.9e-121	38.5
WP_060475335.1\|2323323_2325495_+	copper/silver-translocating P-type ATPase CopB	A0A218MNH6	uncultured_virus	2.9e-71	32.3
WP_060475333.1\|2325606_2327778_-	transglutaminase	NA	NA	NA	NA
WP_002323431.1\|2327767_2328841_-	DUF58 domain-containing protein	NA	NA	NA	NA
WP_002304700.1\|2328854_2329703_-	MoxR family ATPase	NA	NA	NA	NA
WP_002294835.1\|2331419_2331989_+	prevent-host-death protein	NA	NA	NA	NA
WP_002294833.1\|2332164_2332431_-\|integrase	tyrosine-type recombinase/integrase	A0A0P0I3D2	Lactobacillus_phage	2.8e-08	58.7
WP_002294831.1\|2332425_2333118_+	N-acetylmuramoyl-L-alanine amidase	Q9MCC6	Lactobacillus_phage	2.3e-30	43.4
WP_008266934.1\|2333386_2333800_+	DUF4231 domain-containing protein	NA	NA	NA	NA
WP_002295273.1\|2334031_2334289_-	hypothetical protein	NA	NA	NA	NA
WP_002295271.1\|2334451_2335426_+	choloylglycine hydrolase family protein	M1HVK5	Paramecium_bursaria_Chlorella_virus	5.4e-25	31.8
WP_002322761.1\|2336213_2336531_+	hypothetical protein	NA	NA	NA	NA
WP_002289810.1\|2336734_2337100_-	hypothetical protein	NA	NA	NA	NA
WP_002302564.1\|2337307_2337790_+	hypothetical protein	NA	NA	NA	NA
WP_002289807.1\|2337986_2338877_+	phosphate ABC transporter substrate-binding protein PstS family protein	NA	NA	NA	NA
2338214:2338229	attL	NA	NA	NA	NA
WP_010728667.1\|2339202_2341677_+	cation-translocating P-type ATPase	M1HBF8	Paramecium_bursaria_Chlorella_virus	1.7e-46	29.2
2338214:2338229	attL	NA	NA	NA	NA
WP_002293703.1\|2341779_2343516_-	two-component sensor histidine kinase	W8CYF6	Bacillus_phage	9.3e-28	34.1
WP_002293705.1\|2343512_2344217_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.4e-38	36.2
WP_002297194.1\|2344347_2344851_+	DUF523 domain-containing protein	NA	NA	NA	NA
WP_002293708.1\|2344810_2345149_+	putative DNA-binding protein	NA	NA	NA	NA
WP_002293709.1\|2345169_2346588_+	signal recognition particle protein	NA	NA	NA	NA
WP_002293710.1\|2346699_2347278_+	DNA-3-methyladenine glycosylase I	NA	NA	NA	NA
WP_002293712.1\|2347229_2347802_+	dihydrofolate reductase	NA	NA	NA	NA
WP_002293714.1\|2347880_2348435_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	2.3e-12	29.3
WP_002290274.1\|2348687_2348963_+	30S ribosomal protein S16	NA	NA	NA	NA
WP_010728670.1\|2348974_2349226_+	KH domain-containing protein	NA	NA	NA	NA
WP_002325027.1\|2349349_2350141_+	hypothetical protein	NA	NA	NA	NA
WP_002293716.1\|2350310_2350832_+	ribosome maturation factor RimM	NA	NA	NA	NA
WP_002293717.1\|2350821_2351583_+\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_002286913.1\|2351718_2352066_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_025480646.1\|2352197_2353238_-\|integrase	site-specific integrase	A0A1P8BMN3	Lactococcus_phage	4.3e-44	34.1
WP_002333440.1\|2353279_2353960_-\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.7e-126	98.7
WP_002292418.1\|2357622_2358495_-	ROK family protein	NA	NA	NA	NA
2355221:2355236	attR	NA	NA	NA	NA
WP_002293868.1\|2358758_2360705_-	PTS beta-glucoside transporter subunit IIBCA	NA	NA	NA	NA
2355221:2355236	attR	NA	NA	NA	NA
WP_002293865.1\|2360889_2362329_+	sucrose-6-phosphate hydrolase	NA	NA	NA	NA
WP_002302077.1\|2362330_2363293_+	LacI family transcriptional regulator	C6ZCU4	Enterobacteria_phage	2.3e-20	25.8
WP_104841954.1\|2363462_2364889_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	3.0e-48	39.8
WP_002295182.1\|2365131_2365587_+\|transposase	IS200/IS605 family transposase	A0A0H3UZM0	Geobacillus_virus	4.3e-17	38.2
WP_002289255.1\|2366172_2366403_-	resolvase	NA	NA	NA	NA
WP_002289254.1\|2366632_2367451_-	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_002289253.1\|2367611_2368301_+	N-acetylmannosamine-6-phosphate 2-epimerase	NA	NA	NA	NA
WP_002295185.1\|2368314_2369817_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_002295186.1\|2369829_2370306_+	PTS glucose transporter subunit IIA	NA	NA	NA	NA
WP_010728675.1\|2370464_2371424_-\|transposase	IS30 family transposase	NA	NA	NA	NA
WP_002333089.1\|2371720_2373046_+	Y-family DNA polymerase	M1Q231	Streptococcus_phage	1.0e-98	43.4
WP_002290348.1\|2373038_2373389_+	hypothetical protein	NA	NA	NA	NA
WP_002337288.1\|2373536_2374445_+\|transposase	IS982-like element ISEfm1 family transposase	NA	NA	NA	NA
WP_002295273.1\|2374638_2374896_-	hypothetical protein	NA	NA	NA	NA
WP_002295271.1\|2375058_2376033_+	choloylglycine hydrolase family protein	M1HVK5	Paramecium_bursaria_Chlorella_virus	5.4e-25	31.8
WP_033581966.1\|2376571_2376877_-	hypothetical protein	NA	NA	NA	NA
WP_002293960.1\|2376876_2377107_-	hypothetical protein	NA	NA	NA	NA
WP_002293958.1\|2377660_2377903_+	DUF2087 domain-containing protein	NA	NA	NA	NA
WP_002288972.1\|2377990_2378104_-\|protease	CAAX amino protease	NA	NA	NA	NA
WP_002293957.1\|2378253_2378508_+	hypothetical protein	NA	NA	NA	NA
WP_021108906.1\|2378536_2379796_+	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_002293955.1\|2379848_2380745_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_002293954.1\|2380755_2381625_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_002297646.1\|2381634_2382297_+	DUF624 domain-containing protein	NA	NA	NA	NA
WP_002293952.1\|2382502_2384167_+	acetolactate synthase AlsS	NA	NA	NA	NA
WP_002289619.1\|2384179_2384890_+	acetolactate decarboxylase	NA	NA	NA	NA
WP_002293950.1\|2385019_2385517_+	GAF domain-containing protein	NA	NA	NA	NA
WP_002289617.1\|2385701_2385962_+	hypothetical protein	NA	NA	NA	NA
WP_002321266.1\|2386323_2386563_-	hypothetical protein	NA	NA	NA	NA
WP_002323892.1\|2386848_2387163_+	hypothetical protein	NA	NA	NA	NA
WP_060475331.1\|2387678_2388821_-\|integrase	site-specific integrase	P97010	Streptococcus_pyogenes_phage	5.5e-69	42.8
WP_060475329.1\|2388930_2389602_-	DUF5067 domain-containing protein	NA	NA	NA	NA
WP_060475327.1\|2389695_2390352_-	helix-turn-helix domain-containing protein	Q9G0C2	Lactococcus_phage	2.8e-49	45.9
WP_060475325.1\|2390509_2390755_+	helix-turn-helix transcriptional regulator	Q38329	Lactococcus_phage	2.9e-12	52.6
WP_060475323.1\|2390755_2391508_+	phage antirepressor	B2ZYU5	Staphylococcus_phage	2.1e-69	57.0
WP_060475321.1\|2391522_2391726_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_060475318.1\|2391740_2391968_+	hypothetical protein	NA	NA	NA	NA
WP_002351655.1\|2392156_2392939_-	hypothetical protein	NA	NA	NA	NA
WP_002323906.1\|2393085_2393427_+	hypothetical protein	NA	NA	NA	NA
WP_060475316.1\|2393419_2394091_+	DUF1071 domain-containing protein	A0A1B1P7F0	Bacillus_phage	5.5e-29	47.8
WP_060475314.1\|2394096_2394783_+	hypothetical protein	C9E2N1	Enterococcus_phage	1.1e-88	69.5
WP_060475312.1\|2394785_2395616_+	replication protein	C9E2N2	Enterococcus_phage	2.9e-51	43.5
WP_060475310.1\|2395633_2396485_+	ATP-binding protein	A0A0P0I3L9	Lactobacillus_phage	4.7e-25	28.3
WP_002321420.1\|2396481_2396841_+	DUF1064 domain-containing protein	A0A1P8BKR1	Lactococcus_phage	1.1e-18	48.3
WP_060475308.1\|2396855_2397005_+	hypothetical protein	NA	NA	NA	NA
WP_060475306.1\|2397001_2397298_+	hypothetical protein	NA	NA	NA	NA
WP_002332450.1\|2397372_2397786_+	ArpU family phage transcriptional regulator	C9E2P5	Enterococcus_phage	5.6e-56	80.3
WP_060475304.1\|2397798_2398185_+	hypothetical protein	O34053	Streptococcus_phage	5.4e-29	54.3
WP_002332449.1\|2398460_2398727_+	hypothetical protein	NA	NA	NA	NA
WP_060475302.1\|2398890_2399820_+	hypothetical protein	NA	NA	NA	NA
WP_060475299.1\|2399885_2400113_+	hypothetical protein	NA	NA	NA	NA
WP_060475297.1\|2400112_2400631_+	hypothetical protein	NA	NA	NA	NA
WP_021108997.1\|2400633_2401008_+	HNH endonuclease	A0A249XUN4	Enterococcus_phage	3.0e-32	55.8
WP_060475295.1\|2401172_2401652_+\|terminase	phage terminase small subunit P27 family	A0A0M3UL59	Enterococcus_phage	9.1e-42	59.1
WP_002333643.1\|2401644_2403369_+\|terminase	terminase large subunit	D7PQ39	Enterococcus_phage	1.3e-167	53.0
WP_060475294.1\|2403542_2404727_+\|portal	phage portal protein	V5US36	Enterococcus_phage	2.7e-79	43.7
WP_060475291.1\|2405260_2406394_+\|capsid	phage major capsid protein	Q9AZY5	Lactococcus_phage	1.2e-81	53.3
WP_080375530.1\|2406390_2406648_+	hypothetical protein	A5GYM0	Lactococcus_phage	8.6e-15	61.8
WP_060475290.1\|2406659_2406944_+\|head,tail	phage gp6-like head-tail connector protein	A0A0M4S687	Enterococcus_phage	2.5e-15	46.8
WP_060475288.1\|2406921_2407257_+\|head	phage head closure protein	C0LZZ3	Enterococcus_phage	3.5e-16	38.7
WP_002290643.1\|2407253_2407649_+	hypothetical protein	A0A0M5M1E5	Enterococcus_phage	5.8e-18	41.7
WP_002329393.1\|2407645_2408017_+	hypothetical protein	A0A060ANH4	Enterococcus_phage	2.5e-23	46.2
WP_060475286.1\|2408032_2408593_+\|tail	phage tail protein	A0A060AI59	Enterococcus_phage	9.0e-41	47.3
WP_002335843.1\|2408717_2409029_+	hypothetical protein	A0A0M4R2F4	Enterococcus_phage	2.3e-14	46.7
WP_002290636.1\|2409052_2409244_+	hypothetical protein	NA	NA	NA	NA
WP_060475284.1\|2409243_2413797_+	tape measure protein	A0A060ANI0	Enterococcus_phage	7.4e-226	49.6
WP_060475282.1\|2413807_2414638_+\|tail	phage tail family protein	A0A059T6D8	Listeria_phage	1.3e-51	40.4
WP_060475280.1\|2414646_2415666_+	hypothetical protein	Q9T1A5	Listeria_phage	8.5e-106	54.7
WP_060475278.1\|2415665_2416715_+	hypothetical protein	A0A0B5D0C2	Listeria_phage	2.5e-20	26.7
WP_060475276.1\|2416714_2418847_+\|plate	BppU family phage baseplate upper protein	A0A288TYH2	Enterococcus_phage	1.7e-116	59.2
WP_060475274.1\|2418858_2419305_+	hypothetical protein	NA	NA	NA	NA
WP_080262858.1\|2419306_2419444_+	XkdX family protein	NA	NA	NA	NA
WP_002312831.1\|2419478_2419721_+\|holin	holin	D2J075	Enterococcus_phage	2.0e-21	62.0
WP_060475272.1\|2419734_2419947_+\|holin	holin	C9E2L0	Enterococcus_phage	6.4e-24	85.9
WP_060475270.1\|2419943_2420963_+	N-acetylmuramoyl-L-alanine amidase	A0A1G5SA77	Enterococcus_phage	2.9e-61	67.2
2424054:2424075	attR	NA	NA	NA	NA

DBSCAN-SWA_5

2425956 : 2435772

Streptococcus_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002293942.1\|2425956_2426673_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.0e-33	35.7
WP_002293941.1\|2426672_2428121_+	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	2.3e-19	29.3
WP_002288586.1\|2428190_2428700_-	hypothetical protein	NA	NA	NA	NA
WP_002297641.1\|2428689_2429415_-	hypothetical protein	NA	NA	NA	NA
WP_002293938.1\|2429637_2431758_-	LTA synthase family protein	W6LM83	Streptococcus_phage	3.7e-220	58.3
WP_002293936.1\|2431987_2433166_+	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	7.8e-103	49.2
WP_002293935.1\|2433181_2433940_+	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	8.5e-26	36.9
WP_002288577.1\|2433962_2434448_+\|tRNA	Cys-tRNA(Pro) deacylase	NA	NA	NA	NA
WP_002293934.1\|2434518_2435772_-	NAD(P)/FAD-dependent oxidoreductase	A0A2H4PQX1	Staphylococcus_phage	4.5e-24	55.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP012522

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection