CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP012069	Olsenella sp. oral taxon 807 strain F0089 chromosome, complete genome	39 crisprs	PD-DExK,csa3,DEDDh,cas2,cas1,cas4,cas7,cas8c,cas5,cas3,PrimPol,WYL,DinG	15	6	9	1

1. NZ_CP012069

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012069_1

• CRISPR_ID: NZ_CP012069_1
• CRISPR_location: 6700-6917
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP012069_1

Consensus_repeat	Method
CGACGCCCTGGGAAACGTCACCTCCTACTCCTGGGACGCCGAGGGCGACCTCG	PILER-CR

spacers of NZ_CP012069_1

>1.1|6753|43|NZ_CP012069|PILER-CR
TGCGGGTGACGGACCCCCTGGGCGGCCAGACGAGCTACGGCCA
>1.2|6849|68|NZ_CP012069|PILER-CR
CTGACGGACGCGGGGGGCGTCACGAGGCGCTGGTCCTACGACGGGCGCGGCCTCGTCTCGTCGGCGAG

CRISPR arrays and Neighbor proteins around NZ_CP012069_1

CRISPR arrays

The CRISPR arrays of NZ_CP012069_1

>merge|NZ_CP012069|1|6700-6917|PILER-CR
CTACTCCTGGGACGCCGTGGGCGACCTCGTGCGGGTGACGGACCCCCTGGGCGGCCAGACGAGCTACGGCCACGACGCCCTGGGCAACGTCACCTCGCTGACGGACGCGGGGGGCGTCACGAGGCGCTGGTCCTACGACGGGCGCGGCCTCGTCTCGTCGGCGAGCGACGCCCTGGGAAACGTCACCTCCTACTCCTGGGACGCCGAGGGCGACCTGG

>NZ_CP012069|1|1|6700-6917|PILER-CR
CTACTCCTGGGACGCCGTGGGCGACCTCGTGCGGGTGACGGACCCCCTGGGCG	GCCAGACGAGCTACGGCCACGACGCCCTGGGCAACGTCACCTC
GCTGACGGACGCGGGGGGCGTCACGAGGCGCTGGTCCTACGACGGGCGCGGCC	TCGTCTCGTCGGCGAGCGACGCCCTGGGAAACGTCACCTCCTACTCCTGGGACGCCGAGGGCGACCTG
G

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342378.1|2499_2697_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342396.1|16600_18355_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051305.1|18808_20371_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|315987
NZ_CP012069.2|WP_050342398.1|18492_18774_+|hypothetical-protein	unknown	unknown	gnl|CDD|379729
NZ_CP012069.2|WP_157051306.1|21764_23021_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342391.1|12044_12509_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342393.1|13541_15236_+|hypothetical-protein	unknown	unknown	gnl|CDD|274730
NZ_CP012069.2|WP_083443681.1|173_1043_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224050
NZ_CP012069.2|WP_050342389.1|9232_9949_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_172674407.1|8867_9236_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342375.1|1454_2285_+|PD-(D/E)XK-nuclease-family-transposase	unknown	unknown	gnl|CDD|273806
NZ_CP012069.2|WP_050342382.1|2822_3935_-|aldo/keto-reductase	unknown	unknown	gnl|CDD|224370
NZ_CP012069.2|WP_050342394.1|15238_16210_+|hypothetical-protein	unknown	unknown	gnl|CDD|379736
NZ_CP012069.2|WP_050342402.1|20678_21644_+|hypothetical-protein	unknown	unknown	gnl|CDD|379736

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342375.1|1454_2285_+|PD-(D/E)XK-nuclease-family-transposase	gnl|CDD|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	5.334e-13
NZ_CP012069.2|WP_157051305.1|18808_20371_+|tetratricopeptide-repeat-protein	gnl|CDD|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	0.00167951
NZ_CP012069.2|WP_050342398.1|18492_18774_+|hypothetical-protein	gnl|CDD|379729	pfam15542, Ntox50, Bacterial toxin 50. A predicted RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains two conserved histidine, a serine, two lysine, and a threonine residue and a HxVP motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6, type 7, and MuF-type secretion systems.	2.59237e-12
NZ_CP012069.2|WP_050342382.1|2822_3935_-|aldo/keto-reductase	gnl|CDD|224370	COG1453, COG1453, Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only].	1.94718e-113
NZ_CP012069.2|WP_050342402.1|20678_21644_+|hypothetical-protein	gnl|CDD|379736	pfam15595, Imm51, Immunity protein 51. A predicted immunity protein with an alpha+beta fold and a conserved tryptophan and Dx[DE] motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-RES or Tox-URI1 families. Proteins containing this domain are present in heterogeneous poly immunity loci in polymorphic toxin systems.	1.4316e-05
NZ_CP012069.2|WP_050342393.1|13541_15236_+|hypothetical-protein	gnl|CDD|274730	TIGR03696, tRNA_nuclease_WapA, RHS repeat-associated core domain. This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.	2.75184e-06
NZ_CP012069.2|WP_050342394.1|15238_16210_+|hypothetical-protein	gnl|CDD|379736	pfam15595, Imm51, Immunity protein 51. A predicted immunity protein with an alpha+beta fold and a conserved tryptophan and Dx[DE] motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-RES or Tox-URI1 families. Proteins containing this domain are present in heterogeneous poly immunity loci in polymorphic toxin systems.	1.79719e-06
NZ_CP012069.2|WP_083443681.1|173_1043_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	1.92423e-113

Protein sequences

>NZ_CP012069.2|WP_050342382.1|2822_3935_-|aldo/keto-reductase
MDKDVACATPKLGFGLMRLPRRLGRIDIRQVSQMVDAFLEGGFTYFDTAYVYVGSEDAVAKALVKRHPRESYTLASKLYAPIALSERSARKQLEASLRRTGAGYLDYYLLHALSRSNYRKYERLHLWDYAQRQREAGLIKHVGFSFHSDPELLDQLLLEHPEVDFVQLQLNYADWESASVMSRQNYEVARRHGKPIVVMEPVKGGKLANPPREAARLMREASPDMSCASWAVRFVASLEGILTVLSGMSNLAQMQDNLSYMRDFRPLDEREHALIRRVQAIVGTSPIIPCTACQYCVKGCPKHIPIPDVFAAMNLRLGDGLIEAARLAYGKATGGRGLASDCIRCGQCNHVCTQNIDVMARLRETALALE
>NZ_CP012069.2|WP_050342378.1|2499_2697_+|hypothetical-protein
MLALLPYARGDNTAKFSVPKGYCVERSLHRYPRPTTLIFETGGHLMVGHGQEISEAVCDFIDKGG
>NZ_CP012069.2|WP_050342375.1|1454_2285_+|PD-(D/E)XK-nuclease-family-transposase
MAQARRDMGELRPIDDLMFRVMARDEAFCGELLGVLLQDRGLTVVKSTPQSHVTNARGRSAVLDALCELSDGRLVNVEVQRADDDDLQRRVRYYASLVTTDRTPPGARFADVPDVCVALVCEFDPLGEGCPLYHVDRVVREGGRALDNGLEELYVNALARDGGEVSALMRVFTEAEAYDEARFPETSRVKRRLRETEEGREDMGSVIEEIREEIRAECIAEGEERGTLKTLVRLVRDGLVSVQDAAASAGVNADEIRRVLAQGSARTAPAPGRVRT
>NZ_CP012069.2|WP_083443681.1|173_1043_+|ABC-transporter-ATP-binding-protein
MSDEKRDVAAGVDAAGADDVAKADDAARGAAGVPAIEYRHVTKAFEGESNDTSKLALDDVSLSIGRGEFVCVIGSSGGGKTTLLKMANGLVMPTSGDVLVDGKNVRNTDLVELRRNIGYAIQGSVLFPHMTVEQNISYVPNLWNGRDHERTRGAVRKWMGIVGLDDDLLERFPAELSGGQQQRVGIARALAASPDILLMDEPFGAVDEITRGQLQCEMRRIYEKTSITVMFVTHDIREALRLGTRVAVVDGGHVLQYAEPAELLAHPTDGFVQRLVAGISPEDLEWRRT
>NZ_CP012069.2|WP_172674407.1|8867_9236_+|hypothetical-protein
MSKFASHGDDVAGAVANSRRAAFRQAKRDLGIPVSRQPDKVHKVIKDIHGKVIPGGRGYQFNTGVIIGENGSPKALHRDIFDHPNGHVFPDGGRVGPHFNTQVVDKDKVTWGKEHYWYGKGT
>NZ_CP012069.2|WP_050342389.1|9232_9949_+|hypothetical-protein
MTGGVLPMDGPLGSWGCEVRRPGEGDELLDSLGPGHLCLGLGYNGWLYREGEGADRDLAAWALACLRAAGADGMGVLCHALVCGGGRATLLRGLWATCEGGDWDGWERGAEAVVHVNGREWRCAIARGGLSALSRLLTGPLGVVTYLGPRGTEWSAPLAADLLRACLGEGEHPGLRECELVLDAGAAYLWTYGDPGAGPTVNFVWREGAPLAGLLARAARAAPGLAPPPRSYARRHLP
>NZ_CP012069.2|WP_050342391.1|12044_12509_+|hypothetical-protein
MRSQPMRSLASGPAADATDGTGTRRFPRGRPTASPTDPLSFPEWGSRNLDPRRQRALVCEDSRDSAALPKSIRPASVASPGTTARGTPPTGPRTSTSPSQKHSALSHPVATQRLDLDRRGAAAGGSGPGLLPATTATKLPQAPRMVPGAQSSPR
>NZ_CP012069.2|WP_050342393.1|13541_15236_+|hypothetical-protein
MAAAGDLRAHGAGPGPPRAHSGRPADRRARAVPGARLRRARRDLSLGPRQPARTRGDGRRSHGAGLPAGGTGPRHDDAVAEPFLGTSEDGTCHPRGLAARKEARLASAGYVEGCHDRRRPHPAIDYHIPERRWTHSSSARARWSRERRRCHWRHDYGPLAVRGVETVHWASLDEWGSELPGGRDAGAGGLWAGLEGLCGPEGGWSAGPRAYSPASRAFLSPDPEAPDASDPATAAAYSYAGGSPLSMVDPSGGRATPAQGGWDEQSWRATQARRAVEAGVRDAAEFAGILDRHTESYSELVCGVIARGQRTTYTVNPHGVLNVAGMIPGPVGFAADIANTGLYVWEGDWAGAGMSAAPRVFDIFRAGRAASSSTRFASRGDDVARAATRGEGFASRTWSRAKSAFRSFRDEVGDRVRWVAGSESGGIPDLGKKLGISEEKLAAWKKKQFDKWLNRGAADTKVYFGKMGEEVRYVGITRQDLDKRLAQHWLTGRCFDKLPPVYGDKLFTRHQAKALEQYNINAYGGARAHGGETLMNIIDSIGKRNRYREQALAWAEEYVRNGGA
>NZ_CP012069.2|WP_050342394.1|15238_16210_+|hypothetical-protein
MGGSRTCGEGGNVLVRRRDERLARQPEQVRRALEALDEYPCPFQLRVLRRSRAYPEPGETFRLEPPCCPPLEGVVVNSHVDFKIDKGFIVVLVFAPGVSPEAALSMGVPPESLMIRPQTLTDLYWRRGYFERTGRVEVDRQAIGYGFYWESLPGRDRFEDEWRRPLPAEPRLLGDRGPATDIGVARMIAREAIIRGLCPWPPPGWAPPPPPPAATSEGPCALLDAQHPDALALAARAEGADPACLLNGYAWEAMLPELLERAGRPDLLRGLSTDPEAGALALSYRGRGASSRAAELASLLNALVASGEEVLALVRSGKVDWDE
>NZ_CP012069.2|WP_050342396.1|16600_18355_+|hypothetical-protein
MTTGRQDGRWEGWSRWVSWRVTRYDPARRDWRGAYPSDEWTGCHDIGDAFRDGTLTPGRYLACEDAYVAVVEEAVRESGVEGLRVADIDPLPPPPARLPPLDPADEPEEGAWVPAGRVGAAVRAVLRGDGWARLEGEGLDVHCDGDLYLWLISRRDLPGALSLARGAGLFPERSVSSSLYWERLPALGFPGPSELALMRELVAKRAPYLLGSLGDGASLFRLRGQGLYDLSHCVCEGVRDRLEAAPSGARRLGNAGRLVGCPLERLYWTVVVCSDAEAAELPDPPACPPPPACPAGSWGSWLLASRDPAIEWAAYDDGEDGEGDEEDDEGDCDDCGEDPWWSSCDDVGGTFLDGELTPGRYLACEEALARAVGECAAEAGAGALTVREAIPPDPPDPEWTPRRPARPDVPLPPAGARAPEEGEVVKADQLVAAVRAMVRDGGRFRLGGERGFLACVGRGLRAHVACRSRPARALSRAGARGLFAGPSLPWMRRPELEALGFPCPEELKLIRGCLARRAPRLLGEVTDAASLYRLDEADRIDLEWSVRAGMQELGVDPDLPPNAYRCLPERLHHCMWAFGRWSDG
>NZ_CP012069.2|WP_050342398.1|18492_18774_+|hypothetical-protein
MAGHGGHQGGGGIPRGTMGDARDLSERFAGEGQVLDREGRRRRVDFGQIIGLCIDPETGRSGEATMGTVHTSERKGEHIVPARPRNWPWERGR
>NZ_CP012069.2|WP_157051305.1|18808_20371_+|tetratricopeptide-repeat-protein
MRPYVLPARTGLGERALRGRLGEARALAERDPGRGLPPTAALSGELAGLLWGRGRAREAVSALREALAAARALAAGDPLQFHADLFAACCDLRGLVGPGAEGLCREALRAERSLAGPGEPTRDLASALDDLSPLMEALELYGEAEGLCREAVSAWRPLAARDPEGCLPSLALACESLAYSLSDDGRFGEAEGLCREAVSAWRALADGGRRGALPWLLSSCRGLAHVLGEVGSLAEAVSAHREAVSVARSLAALDPEGYLPSLATERWHLALTLDEAGRPGEAEPLLREALSALRALAARDPGTWPDLARACGSLADLLTELGRPGEAEAPLREALSTRRALAALDPNARLDLAYTCGSLADLLTELGRPGEAEAPLREQVDIESSVLGECPNGPRERFVALLRGQLGTLLERLGRPGEAEPLLREALGSYRSFTGVEREMSAGMAAPVLVSLGRLLAARGRPGEAGPLLREALSMYASLAAYEGGVDEEYTPAERARWRSAIRRGEREAREALARLGGEA
>NZ_CP012069.2|WP_050342402.1|20678_21644_+|hypothetical-protein
MTSLENCGGTLLARRRDERVARQPEQVRRALGELDEDPRFFQLRALRRSRAYPEPGDTFRLEPPCCPPLEGVVVNSHVDPMEEDAIVVLVFAPGVSLEAALPMGVPPESLMIGPQMLTDLYWRRGYLERIGRVEVDRRSIGYGFYVIDPLCREDRFEDEWGRPLPAEPRLLGGRGLATDVGVAWEVAREALIRGLCPWPPPGWAPPPPPPAATSEGRRALLDAQHPDALALAARAEGVDPACLLNGYAWGAMLPELLSRAGRPDLLRGLSTDPEAGALALSYRGRGASSRAAELASLLNALVASGEEVLALVRSGKVDWDG
>NZ_CP012069.2|WP_157051306.1|21764_23021_+|hypothetical-protein
MAGMAYESVRERPHAPFAEMGRREAAEHARWFASTVGERVESLRSYALAHGCGGPLDLSRESLLPLWSWFLGRSEVARPPGGGPGRLSGESAALARDINVYLCEAVRSAAWGRLSWGCVPGPRSHADANRPALLGFAWNLSMAGDGGEALLGGDREPDPGMLVDVFAHRLSQVPGPGPWRPWGHWGVPLGRDLADTPALEGRLDDLLHRMGDPEVGEEALWTSSEDSRSWRAHREARSRGLRQEACLAAAGRLASAHPGRRWRDYRRAAYVLMGHLLPRRASEAHVSLYLGRLAEETDREVLMCLLDGMEDVPAPAGEDPSAVVRMAREGRGQLAMCATAALGSFDCDEARAELRRRASEPVGNRNVYVVERAVEGLGKVGLAGDLALVEGVARTRRRDLRIVARGAADFIRNRALGE

Crispr_ID: NZ_CP012069_2

• CRISPR_ID: NZ_CP012069_2
• CRISPR_location: 144713-144813
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_2

Consensus_repeat	Method
GGCTATGACCTCAACCGCATCGAGGA	CRISPRCasFinder

spacers of NZ_CP012069_2

>2.1|144739|49|NZ_CP012069|CRISPRCasFinder
CGTCCCCCCTCGCCCAAGAGCCAACTGTGCCAGGCGGCATGATGGGCCA

CRISPR arrays and Neighbor proteins around NZ_CP012069_2

CRISPR arrays

The CRISPR arrays of NZ_CP012069_2

>merge|NZ_CP012069|2|144713-144813|CRISPRCasFinder
GGCTATGACCTCAACCGCATCGAGGACGTCCCCCCTCGCCCAAGAGCCAACTGTGCCAGGCGGCATGATGGGCCAGGCTACGACCTCAACCGCATCGAGGA

>NZ_CP012069|2|1|144713-144813|CRISPRCasFinder
GGCTATGACCTCAACCGCATCGAGGA	CGTCCCCCCTCGCCCAAGAGCCAACTGTGCCAGGCGGCATGATGGGCCA
GGCTACGACCTCAACCGCATCGAGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342601.1|140583_140901_+|hypothetical-protein	unknown	unknown	gnl|CDD|379306
NZ_CP012069.2|WP_050342615.1|148960_149146_+|antitoxin-VbhA-family-protein	unknown	unknown	gnl|CDD|375921
NZ_CP012069.2|WP_050342606.1|143423_143651_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342621.1|150992_152474_+|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|225420
NZ_CP012069.2|WP_083444065.1|150354_150981_+|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341141
NZ_CP012069.2|WP_050342628.1|159722_160394_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP012069.2|WP_083443706.1|149138_149795_+|Fic-family-protein	unknown	unknown	gnl|CDD|225095
NZ_CP012069.2|WP_050342589.1|136895_137897_+|IS5-family-transposase	unknown	unknown	gnl|CDD|376573
NZ_CP012069.2|WP_050342624.1|156182_157115_-|site-specific-integrase	unknown	unknown	gnl|CDD|271189
NZ_CP012069.2|WP_050342598.1|140152_140446_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342612.1|145154_147728_+|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl|CDD|223363
NZ_CP012069.2|WP_050342602.1|141151_141646_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NZ_CP012069.2|WP_050342608.1|144032_144239_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342587.1|135580_136414_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP012069.2|WP_050342613.1|147724_148933_+|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341181
NZ_CP012069.2|WP_157051325.1|138744_139617_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051327.1|157913_159371_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|224586
NZ_CP012069.2|WP_050342622.1|152473_155629_+|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl|CDD|223683
NZ_CP012069.2|WP_050340811.1|133878_134952_-|IS5-family-transposase	unknown	unknown	gnl|CDD|376573
NZ_CP012069.2|WP_050342604.1|142057_142300_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342601.1|140583_140901_+|hypothetical-protein	gnl|CDD|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	0.000228649
NZ_CP012069.2|WP_050342615.1|148960_149146_+|antitoxin-VbhA-family-protein	gnl|CDD|375921	pfam18495, VbhA, Antitoxin VbhA. VbhT is a bacterial Fic protein of the mammalian pathogen B. schoenbuchensis7,8. It is composed of an N-terminal FIC domain and a C-terminal BID domain. FIC domains are known to catalyse adenylylation (also called AMPylation). This entry represents VbhA, an antitoxin that binds FIC domain (filamentation induced by cyclic AMP) of VbhT and inhibits its activity. It inhibits the adenylylation activity of VbhT by positioning close to the putative ATP-binding site, hence competing with ATP binding.	2.20746e-11
NZ_CP012069.2|WP_050342589.1|136895_137897_+|IS5-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	1.38993e-17
NZ_CP012069.2|WP_083444065.1|150354_150981_+|restriction-endonuclease-subunit-S	gnl|CDD|341141	cd17252, RMtype1_S_EcoKI-TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.EcoKI TRD1-CR1, S.StySPI TRD1-CR1, S.Ara36733II TRD1-CR1, and S.Eco3722I TRD1-CR1. Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) and Escherichia coli NCM3722 S subunit (S.Eco3722I) recognize 5'... AACNNNNNNGTGC ... 3', Salmonella enterica subsp. enterica serovar Potsdam S subunit (S.StySPI) recognizes 5'... AACNNNNNNGTRC ... 3', and Actinomyces radicidentis S subunit (S.Ara36733II) recognizes 5'... CATCNNNNNNCTC ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, S.EcoKI-TRD1 and S.StySPI-TRD1 recognize AAC/GTT, S.EcoKI-TRD2 recognizes GCAC/GTGC, and S.StySPI-TRD2 recognizes GYAC/GTRC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It also includes TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases such as Treponema pedis T A4 putative Type IIG restriction enzyme/N6-adenine DNA methyltransferase RM.TpeTA4ORF2695P. It may also include type I DNA methyltransferases.	1.83061e-28
NZ_CP012069.2|WP_050342628.1|159722_160394_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.45911e-58
NZ_CP012069.2|WP_083443706.1|149138_149795_+|Fic-family-protein	gnl|CDD|225095	COG2184, Fic, Protein involved in cell division [Cell division and chromosome partitioning].	5.17762e-36
NZ_CP012069.2|WP_050342621.1|150992_152474_+|putative-DNA-binding-domain-containing-protein	gnl|CDD|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	3.86651e-65
NZ_CP012069.2|WP_050342624.1|156182_157115_-|site-specific-integrase	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.26611e-45
NZ_CP012069.2|WP_157051327.1|157913_159371_-|AAA-family-ATPase	gnl|CDD|224586	COG1672, COG1672, Predicted ATPase (AAA+ superfamily) [General function prediction only].	1.81409e-33
NZ_CP012069.2|WP_050342612.1|145154_147728_+|type-I-restriction-modification-system-subunit-M	gnl|CDD|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	2.24837e-108
NZ_CP012069.2|WP_050342602.1|141151_141646_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	5.93521e-16
NZ_CP012069.2|WP_050342613.1|147724_148933_+|restriction-endonuclease-subunit-S	gnl|CDD|341181	cd17292, RMtype1_S_LlaA17I_TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to the S subunit TRD2-CR2 regions of Lactococcus lactis subsp. cremoris A17 (S.LlaA17I), Haemophilus influenzae Rd (S.HindORF215P) and Clostridium species ASF502 (S.Csp502ORF478P). Lactococcus lactis subsp. cremoris A17 S subunit (S.LlaA17I) recognizes 5'... CAANNNNNNNNTAYG... 3', while the recognition sequences of Clostridium species ASF502 S subunit (S.Csp502ORF478P) and Haemophilus influenzae Rd S subunit (S.HindORF215P) are undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It also includes TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases, such as Porphyromonas species COT-108 OH1349 Type IIG restriction enzyme/N6-adenine DNA methyltransferase (RM.Psp1349ORF730P) of unknown recognition sequence. It may also include type I DNA methyltransferases.	3.40007e-81
NZ_CP012069.2|WP_050342587.1|135580_136414_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.59978e-20
NZ_CP012069.2|WP_050342622.1|152473_155629_+|type-I-restriction-endonuclease-subunit-R	gnl|CDD|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	5.40177e-106
NZ_CP012069.2|WP_050340811.1|133878_134952_-|IS5-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.72577e-22

Protein sequences

>NZ_CP012069.2|WP_050342608.1|144032_144239_+|hypothetical-protein
MKHSEFVDLGTSPAEAQALLMDFESVAVAMRMPRTLRDSPPKGSVTPDGMSITSAGMCLIDRLPREVC
>NZ_CP012069.2|WP_050342606.1|143423_143651_+|hypothetical-protein
MARFSKSREEHHAWSGRYATEAHDPPPRTGRAEREHVASWFGANPTIGSGAHSRQSGNSSAKVRYDRPQGAAPLP
>NZ_CP012069.2|WP_050342604.1|142057_142300_+|hypothetical-protein
MAEKPEWVKSFARPRGTEIKHIRGHWYLYERGSIYDPKIKRSRKKSGRCLGKITPEGLVASVSRKERAERARVAGFTAAG
>NZ_CP012069.2|WP_050342602.1|141151_141646_-|helix-turn-helix-transcriptional-regulator
MDMVKVGSFLQELRRQSNVTQEQLAERMGVARRTVSRWETGRNMPDLDILVELADFYEVDLREILNGERKGEHMNEELRETALQVAEYSGEEKLKITRRMHWLFLAGLASATVYLVLVLTNKADDFGGGLCLGIEFGTVIIGVIMTSRYAAKIREFKLRLLARQ
>NZ_CP012069.2|WP_050342601.1|140583_140901_+|hypothetical-protein
MQCRALPGAARAPYVRLPLRYFTKKGIGEFDLVTERKDGAIIALEIKSGRGYKAHAAIDDALKIEHYHIDEAYVLAECHVGRDDTLLYLPVYSIGLMRNSWAGRG
>NZ_CP012069.2|WP_050342598.1|140152_140446_+|hypothetical-protein
MASKEDISGMPLSVKAVFLRPDELHTGALGVKSLIFCDNRLGLSHPEVRILGGVRTRPRGSRARPGGRSGCGEHLHVRPAEGAWSLSRCRRVVNESL
>NZ_CP012069.2|WP_157051325.1|138744_139617_+|hypothetical-protein
MNPSSQPQSFAPQTSIAAAQRDASTLQSAFQPQQVSGGGWAEGSSHVQVQATSLVNGAKATWSTPYAIVSLVGKVIAVIALLMPCVSSPLLTAQLSSGGSSLFSILSNYTQASELQDIARGEWSMWSLNGLANSVNSLVSSLNKAWEAYGSSLGSGYASGGSNLEPLASLITTLATIVTIVWALMIVALVFTIVRPFVKNGRPAAHERRSGIDTAILVVVGLLCLAWCGIVTSVNGIIMSTLSSTLSSYNLPTVTLPNFLEVPLWPWVAAIASLLMAFWPRLSRRMGLSA
>NZ_CP012069.2|WP_050342589.1|136895_137897_+|IS5-family-transposase
MVLTRRRGSFADLEASGQRRRTRRERFLEQMEAIVPWREWVALIESHYPDGRRGRRPVGRGRMPGTCLLQVWFHLSDEACEDAVLDSRATRRFVGIDMMSEQVPDATTLPEFRHLLEGEGLGEGMLAELVSILDERGIIMRGGSIVDATFVESPSSTKNRERSRDPEAHQAKKGNNWHFGYKAHAGVDAGTGLAHTVEVTAANVSDVAVAPSLLRPDDEFCYAGAGHAGARGRQQAPGHPDPSEVTWRIARRRSRVPGRDHPEVSWERGIESSLSRVRSKVEHPFHVIKDLFGLRRTRYRGLEKNRNQLCVAFALADLALLAQAGRTLAPTCA
>NZ_CP012069.2|WP_050342587.1|135580_136414_+|alpha/beta-hydrolase
MSKDRAESKFLTVGPDIQVHYWDKGEGDAIVFIPGLTFSGEIFRHQLEHFSDRHRVIAVDPRGQGLSTKTVYGNDYVTHGADVRRLVDALSLENVTLVGWSTGNLEVWSYLEQAGYDKVAGVVTIDMSPLPLCEDPAWWTEGTPAELSEVATRVLIHPESAEAFWDEYLTQVMMQRELDEDEHEYLMDMSRRTPHWVARQLFCDAILSDYLEVARTAAKTVPTLMYVAEHWADVAEPFCHAQFPETSTCVMGGHLMAYEYPERFNARLEEFLESERR
>NZ_CP012069.2|WP_050340811.1|133878_134952_-|IS5-family-transposase
MAQLTFSDVEMGMGRKRETRRSRFLDRLSKSCPWDAWLALVREARGADAGARGAGPAMGRPRVDDLVLLRMYMVQVCFGLSDRECEDQVWDSATMRSFVGVAPFEVPDATTLCKFRHLLERCGVGEAMVSSAFGSAADGGLAVSRGTIVDATFIESPSSTRNADGARDPDAHQAKKGQNWHFGYKLGVGVDAETGVPHSVRMDAANVHDLDQVPDLVREGDERVWADAGYVGVGRRPEVAGDPSLSGVEWIVAKRRSQVGEDDLVAEAAKSAARSVVEHVFHWVKDIFGLRKTRYKGLAKVSNQAFAAVAAAGCMIARRGRRLCGPPLALSAERIALQRERLEERRRRAEGGAPAAA
>NZ_CP012069.2|WP_050342612.1|145154_147728_+|type-I-restriction-modification-system-subunit-M
MNKQQLAAKIWASANQMRSKIEASEYKDYILGFIFYKFLSDKEERFLAENDFDADAMSCVTEDDAEVLSFVRDNLGYFIAAGDLYSSWLDKGSDFDVSDVRDALSTFERLVRPSYKNVFDRVFETLETGLSKLGETSGAQTKAISALLQLIRSIPMDGRQGYDVLGYIYEYLISNFAANAGKKAGEFYTPHEVSVLISQIVASNLRDRVEIRIYDPTSGSGSLLINIGEAVARRLGSRDSIRYYAQELKENTYNLTRMNLVMRGISPDNIVCRCGDTLEDDWPWFEEGHPETYEPLFVDAVVSNPPYSQRWDPDGKENDPRFDGYGIAPTSKADYAFLLHDLHHLKPDGVMCIVLPHGVLFRGGEEERIRRALVENENIDAVIGLPANIFFGTGIPTIVMVLKKRRPTDDILIIDASKGFVKEGKSNRLRACDIRRIVDAYERRRDIERFCRAVPKQEVRDNGYNLNIPRYVDSSEPAETWDIYATMFGGLPISEVEALKLYWDALPNLCERLFEPAGGSTLRLRVDDIEAAVHDSTAVRAYLDAYERRFSDFEMWLFDKLVDEALLVDRASEEDVLAAEVFGRLEGVPLVDPYDAYQVLDDAWRQVSEDLEVLQTEEFDAAKRVDPNMVVKKKRGRDVEVQEGWRGHVLPFELVQQELLANDLADIRRMDERSLAIDAELSEALEGLSEDDKAALGGAVSDNGDAFVAGRLKACARELHADGDSEELARIVEKASKLFDEQKRLKRQSKQQAIALEAKTKEVIEGLSDEAVRNLLDAKWNRPIVDGLAALPRASVDALVERVRSLADKYSTTFSQVEKQIHDEERKLCDMLGELTGDEFDMAGIRELRALLGGDGR
>NZ_CP012069.2|WP_050342613.1|147724_148933_+|restriction-endonuclease-subunit-S
MSANVPELRFSGFADPWEQRKLGELGVTYGGLTGKSKEDFGHGDARFVPYTNVFDNPIADSTRLGEVEIDVSQNRVLHGDTLFTVSSETPNEVGMSSVWLSDLDNLYLNSFCFGYRQDGSFDPYYLAYMLRSQSVRENIELLAQGISRFNISKGKVMEVEVPVPMMAEQRAVGALFSRLDSLIALHQRKHNQLSVLKSLLLERMFPKPGSDVPELRFSGFADPWEQRKLGEFGSVEMCKRIYKEQTSESGEVPFFKIGTFGSEPDAFISNKLYESYRDEYPYPEPGTPLISAAGSIGRTVVYQGERAYYQDSNIVWLDHDDNLDNSFLDVFYSQVDWKLEGSTIKRLYNKDILNAEVCVPSLPEQRAVGALFSRLDSLIALHQRKLEKLRALKQSLLQKMFV
>NZ_CP012069.2|WP_050342615.1|148960_149146_+|antitoxin-VbhA-family-protein
MDRKRVIDESIHSGEMEGAYVSAEFREDADEYVRGHIPIEELMRRTKRRWEPDREGKGPHV
>NZ_CP012069.2|WP_083443706.1|149138_149795_+|Fic-family-protein
MSDGFVDPYIDLRTGVLRNLVGAGTWDELRNAEGELVAMRMSEFLRELPLEPTGTLDDLRCIHRWLFRDVYDWAGEVRTIEIRKAGEGAQFFLPSANIPMGIAWARSELEKDDFLVGLASRRFPSRMAYHYDNYNFVHPFREGNGRTQRLLWTLICHHAGYDLDWRDVTGAENDEASRLAAEDRDMGALVSIFARIAAPCDPSVPINAGLVQAGHLGG
>NZ_CP012069.2|WP_083444065.1|150354_150981_+|restriction-endonuclease-subunit-S
MACLRWEDIVTHPRRTHAWEQRKLGELGVTYGGLTGKSKEDFGHGDARFVPYTNVFDNPIADSTRLGEVEIDVSQNRVLHGDTLFTVSSETPNEVGMSSVWLSDLDNLYLNSFCFGYRQDGSFDPYYLAYMLRSQSVRENIELLAQGISRFNISKGKVMEVEVPVPMMAEQRAVGALFSRLDSLIALHQRKPDALKTVIKSLLDNILV
>NZ_CP012069.2|WP_050342621.1|150992_152474_+|putative-DNA-binding-domain-containing-protein
MENQDIEYKAVWRDEYLQWLCGFANARGGTIYVGIADDGEVVGVKNADRLLEDIPNKAIAALGIIPYVQLHRENGREFLEISIEPQDFPINCKGRYYLRSGATNQLLRGVGLDTFLLRRRGRTWDSVPVPNVRVQDLSRKAMDSFLGEARGGGRMPDDVAGDDAESLLQSLHLLEGGRCTNAAVLLFHPDPMAVFSSCFVKVGYFNGSEILFQDEVGGPIIGQVDKTLDLLYAKYLRARIDYDGAHRVERFPFPRAAVREAVVNAVVHRNYASTSPIQIRVCDDCLQIGNACILPEGWTVDDLLGFHESEPHNPKIAHVFFLAGLIERWGRGVQRIFSACKIDGVESPLYRMVGNSLQIVFTAPADRVMRIGVQQSDPGDVATHVHADDRDGAVLTRLGATWRDLARLGATYPDFGHRLMEAWDALSARDRGILGQLATDGPTRTADLSDSLGVSLRTVQRTMKKLAVIGLVSLQGKANESRYYLNIDSGKGE
>NZ_CP012069.2|WP_050342622.1|152473_155629_+|type-I-restriction-endonuclease-subunit-R
MADIFTSEAEFEAAVVSCLQDHGWKGGVLRQPTEQGLLDNWAHILYENNKGDRRLNGCPLTQGEMQQILEQVAKLRTPMRLNGFINGGTISITRDNPDDVAHFNREVSLYIYDRRDIASGRSVYQIAEQPIFKASSARLNDRRGDLTLLINGMPLIHIELKRSGVPVSQACNQIEKYAHEGVFTGLFSLVQIFVAMEPAETVYFANPGKDGDFSLYRFHWADFNNEPINEWQRVIATLLFIPMAHQLIGFYSVADERDATLKVMRSYQYYAAAAISDRVRRASWDKRGARGGYVWHTTGSGKTMTSFKSAQLIADSKDANKVVFLVDRIELGTQSLDEYRNFANDSTTVQATQDTDVLRSRLKSDNPADTLIVTSIQKMSNIHEHDGGMTAADLERVREKHIVFIVDECHRSTFGDMMQTVRRTFPTAMLFGFTGTPIQDENQKKMNTTMDVFGDELHRYSIADGIRDHNVLAFDPYMVCTYKDKDVRREVALEKARADSQATALADPKKKKVYLHFMNEVPMAGARRPSGGCDKGVEDYVPESQYSGPDGEGSPEHFRMVLADIVDNWATLSQGGKFHAILATASIPQAITYYRMFRDEAPQLKVTALFDPNIGNDNPDNPAGTIFKEEGLVEILDGYAKLYPGKDYTIPTHARFKKDVAARLAHKRPYVGIERHPDKRLDLLIVVNQMLTGFDSKWVSTLYLDKVLEYEGLIQAFSRTNRLFGPDKPFGIIKYYRYPHIMKRNVDDAVRLYSGDRPFGLFVDKLEANLEHINQCYADISALFSAYGVEGFARLPDPNAARAQFAKLFKQLSDYIEAAKVQGFSWDKDSYAFECEDGAVTVKTALDQQVYLVLALRYKELFQEDDGGDGPTDVPFEIDGYLTEIDTGRIDADYMNENFAKWLKQIDEGEEAQATLSLLHGSFATLTQEQQRFAELVIHAAQRGELEVIPGKTFLDYINDFQQQGRNSQVEALVAATGVNADKLRDLMARHPSADTINEYGRFKALVATCDKKRAAAHFAEKGKGPVRPSQVNMKLDKLLREFVIQGGIDV
>NZ_CP012069.2|WP_050342624.1|156182_157115_-|site-specific-integrase
MLNELTSSDLFHTYYKEWIAVYKEDAVRQVTLNKYKLALGWIERLAPDLTLENLDRLAYQRILNEYAKEHERQTTMDFCHLLKGAVLDAVDEGLVPRDPTRKAIIKGKAPRPKKSRYLNQFELHKLLAGLNLGQKISWEWFILLVAKTGLRFSEALAITPVDFDFTKQTLSVSKTWDYKNGGGFVPTKNRSSVRKVQIDWQLIVQFSVLIKDLPESEPMFVKQGKKVYNSTANNVLARLCKEAGVPVIPIHGLRHTHASLLLFAGVSIASVAKRLGHASMNTTEKTYLHIIQELENKDVDLVMRSLTSLI
>NZ_CP012069.2|WP_157051327.1|157913_159371_-|AAA-family-ATPase
MLEKNDRKGTMFVAREGELTALERMYKRDGFQMAVIYGRRRVGKTTLIDEFVKDKRVLYFTAQQKTSHQNLELLSAATYAAFSLPATLPAFASWNDALRFVVERVGKEPPDTPLVIVFDEFPYAAEANPSLPSALQTTIDHGLKQTDTKLILCGSNEGFMESRVLGSKSPLYGRRTMQMRLNPFDYLDAARMLPGVPPEELVIYYATFGGTPYYLSQVDLSRTYEENVRELFFDRLGLLYEEPLMLLRQELHEPARYNSILDAVGSGNSTPSRIAKRAGVNPNSVGKYLKTLSVLGIIEKVSPLGNGPTSKNSAYRLKDPLFAYWYRFVSRYLGTIEKGAGAAASAYASSGQALSTYVGKQFKDVCLQWVQRESIAGRLPFSALEFGQWWGTDPDAHEETDIDIVAMNRVERELLVGECRWRNSFNETAAIKTLEHRSTLLKGFSRRHFVLFTKRETSAATRRAAADRADLCLVTLDELYAGLNP
>NZ_CP012069.2|WP_050342628.1|159722_160394_-|response-regulator-transcription-factor
MISVMVVDDQRYERLGLALMLKGAEGIRIVAQAENGREAVDALAAASGDEMPDVVLMDVRMPMMDGIDATRIITRAHPGVKVLVLTTYDQDDYALGGLSAGASGFLLKDVTSAELADAVRAVASGDAVLTPRITRKVLGRCFPSSPLASPRGSAPMHKGSFSSLTPREAEVASLVADGFSNAEIAERLVVEPASVRRYVSRILAKTGLRDRVQVAVAWVRAKM

Crispr_ID: NZ_CP012069_3

• CRISPR_ID: NZ_CP012069_3
• CRISPR_location: 223940-224025
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_3

Consensus_repeat	Method
GCAACCTCCCGCCAGCCTGCGGGG	CRISPRCasFinder

spacers of NZ_CP012069_3

>3.1|223964|38|NZ_CP012069|CRISPRCasFinder
CACTATGGAGAATGCCTCAACTGGGCAAACGCGCTCGA

CRISPR arrays and Neighbor proteins around NZ_CP012069_3

CRISPR arrays

The CRISPR arrays of NZ_CP012069_3

>merge|NZ_CP012069|3|223940-224025|CRISPRCasFinder
GCAACCTCCCGCCAGCCTGCGGGGCACTATGGAGAATGCCTCAACTGGGCAAACGCGCTCGAGCAACCCCCCGCCAGCCTGCGGGG

>NZ_CP012069|3|2|223940-224025|CRISPRCasFinder
GCAACCTCCCGCCAGCCTGCGGGG	CACTATGGAGAATGCCTCAACTGGGCAAACGCGCTCGA
GCAACCCCCCGCCAGCCTGCGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342720.1|219899_221006_+|4Fe-4S-binding-protein	unknown	unknown	gnl|CDD|223425
NZ_CP012069.2|WP_050342731.1|227202_227490_+|ferrous-iron-transport-protein-A	unknown	unknown	gnl|CDD|377199
NZ_CP012069.2|WP_050342745.1|233830_234631_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224026
NZ_CP012069.2|WP_157051331.1|210576_211098_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342706.1|210253_210580_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342749.1|234630_235587_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|226605
NZ_CP012069.2|WP_050342716.1|217693_219091_+|Dyp-type-peroxidase	unknown	unknown	gnl|CDD|273606
NZ_CP012069.2|WP_050342724.1|221961_223047_-|ferrochelatase	unknown	unknown	gnl|CDD|234585
NZ_CP012069.2|WP_050342742.1|231054_233163_+|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319848
NZ_CP012069.2|WP_050342734.1|227918_230597_+|ferrous-iron-transporter-B	unknown	unknown	gnl|CDD|223447
NZ_CP012069.2|WP_050342718.1|219255_219888_+|FMN-binding-protein	unknown	unknown	gnl|CDD|226484
NZ_CP012069.2|WP_083444066.1|215179_216157_+|FTR1-family-protein	unknown	unknown	gnl|CDD|272930
NZ_CP012069.2|WP_172674417.1|224834_225680_-|hypothetical-protein	unknown	unknown	gnl|CDD|99777
NZ_CP012069.2|WP_172674418.1|225654_226650_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342722.1|221012_221930_+|FAD:protein-FMN-transferase	unknown	unknown	gnl|CDD|224394
NZ_CP012069.2|WP_050342740.1|230734_231040_+|hypothetical-protein	unknown	unknown	gnl|CDD|215358
NZ_CP012069.2|WP_050342714.1|216219_217545_+|peptidase-M75-family-protein	unknown	unknown	gnl|CDD|271139
NZ_CP012069.2|WP_050342732.1|227658_227895_+|ferrous-iron-transport-protein-A	unknown	unknown	gnl|CDD|224830
NZ_CP012069.2|WP_050342743.1|233396_233726_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342710.1|211282_214981_+|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl|CDD|227321

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342720.1|219899_221006_+|4Fe-4S-binding-protein	gnl|CDD|223425	COG0348, NapH, Polyferredoxin [Energy production and conversion].	8.54554e-17
NZ_CP012069.2|WP_050342731.1|227202_227490_+|ferrous-iron-transport-protein-A	gnl|CDD|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	1.14594e-12
NZ_CP012069.2|WP_050342745.1|233830_234631_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224026	COG1101, PhnK, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	2.31668e-120
NZ_CP012069.2|WP_050342740.1|230734_231040_+|hypothetical-protein	gnl|CDD|215358	PLN02666, PLN02666, 5-oxoprolinase.	0.00272355
NZ_CP012069.2|WP_050342749.1|234630_235587_-|ABC-transporter-permease	gnl|CDD|226605	COG4120, COG4120, ABC-type uncharacterized transport system, permease component [General function prediction only].	7.21446e-83
NZ_CP012069.2|WP_050342716.1|217693_219091_+|Dyp-type-peroxidase	gnl|CDD|273606	TIGR01412, Probable_deferrochelatase/peroxidase_EfeN, Tat-translocated enzyme. This model represents a small family of proteins with a typical Tat (twin-arginine translocation) signal sequence, suggesting that the family is exported in a folded state, perhaps with a bound redox cofactor. Members of this family show homology to Dyp, a dye-decolorizing peroxidase from Geotrichum candidum that lacks any typical heme-binding site.	2.17471e-89
NZ_CP012069.2|WP_050342724.1|221961_223047_-|ferrochelatase	gnl|CDD|234585	PRK00035, hemH, ferrochelatase; Reviewed.	6.93572e-83
NZ_CP012069.2|WP_050342742.1|231054_233163_+|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319848	cd07550, P-type_ATPase_HM, P-type heavy metal-transporting ATPase; uncharacterized subfamily. Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP012069.2|WP_050342734.1|227918_230597_+|ferrous-iron-transporter-B	gnl|CDD|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	7.09541e-125
NZ_CP012069.2|WP_050342718.1|219255_219888_+|FMN-binding-protein	gnl|CDD|226484	COG3976, COG3976, Uncharacterized protein conserved in bacteria [Function unknown].	9.56623e-16
NZ_CP012069.2|WP_083444066.1|215179_216157_+|FTR1-family-protein	gnl|CDD|272930	TIGR00145, Uncharacterized_protein_slr0964, FTR1 family protein. A characterized member from yeast acts as oxidase-coupled high affinity iron transporter. Note that the apparent member from E. coli K12-MG1655 has a frameshift by homology with member sequences from other species. [Unknown function, General].	3.6385e-36
NZ_CP012069.2|WP_172674417.1|224834_225680_-|hypothetical-protein	gnl|CDD|99777	cd06170, LuxR_C_like, C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.	2.00805e-13
NZ_CP012069.2|WP_050342722.1|221012_221930_+|FAD:protein-FMN-transferase	gnl|CDD|224394	COG1477, ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism].	2.61822e-64
NZ_CP012069.2|WP_050342714.1|216219_217545_+|peptidase-M75-family-protein	gnl|CDD|271139	cd14656, Imelysin-like_EfeO, EfeO is a component of the EfeUOB operon. This family includes the EfeO domain, an essential component of the EfeUOB operon which is highly conserved in bacteria. However, its biochemical function is unknown. EfeO contains an N-terminal cupredoxin (CUP)-like domain and C-terminal imelysin-like domain that may bind iron. Algp7, a member of EfeO family protein from Sphingomonas sp. A1, is found to bind alginate at neutral pH, but does not contain the CUP domain, thus having a role that does not seem to be related to iron uptake. Some members of this family are fused to an N-terminal putative EfeU ion permease domain. The imelysin-like domain of this family also contains the GxHxxE sequence motif and a highly conserved functional site, suggesting a similar role to other imelysin family proteins containing the same motif.	2.77102e-66
NZ_CP012069.2|WP_050342732.1|227658_227895_+|ferrous-iron-transport-protein-A	gnl|CDD|224830	COG1918, FeoA, Fe2+ transport system protein A [Inorganic ion transport and metabolism].	2.87489e-19
NZ_CP012069.2|WP_050342710.1|211282_214981_+|thiol-reductant-ABC-exporter-subunit-CydC	gnl|CDD|227321	COG4988, CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	7.98209e-128

Protein sequences

>NZ_CP012069.2|WP_050342724.1|221961_223047_-|ferrochelatase
MAHDTAPHSTTRSIGVIVANTGSPASPAPDDIEAYLGAYLMDPRIRQLPFFLWHLLVFKLILPKRKFTSSRRYQFVWTEKGSPLVTNQELLCRKVQALFEGDRAGELPSVSVMSAMSYGEPSIASRLWQLHEQGCDQLILLPLYPQSAYCITQSVVDSFSRALRELGWNVPYQVIDHYFDNPLYIREVARHITEAGFTNASDEHLVLSFHAIPLKDERAGDSYRSQTRATADLVARELGIDPASIYVCYQSVFGPHEKSWASPLAKDVLAGWRDESSRVYFCCPGFAVDCLETIYDIAHEIVPALEGEGSKPVVERTGGSVERGMNSSGRLIWVGCLNATDEHAAIVKSAIDGALGRLAHS
>NZ_CP012069.2|WP_050342722.1|221012_221930_+|FAD:protein-FMN-transferase
MAGARPPLIEGAGEFFDTLVRIRADCDQRLIDACLARCAFFHGTLSRFDDTSDVGRINAAAGRRVRVAPTTARLVSLALEYSRLTGGLFDITLGVVLELWDFKEGRIPTSSSLEEALRHVSSEHVHVVGTQVWLDDPLAKIDLGGIAKGYVADDLAVGLRAAGCEHAVLNLGGNVLCVGSRPDGSAWRAGVARPGEPFGDPMALCRLKDQGLVTSSLCERAFSCAGRRYGHILDPRSGHPVATDVASVTLRTEHSVDGETLGKKPFFLGMAEALSYLDSLEGVDALLVGMDGSVAQTSAGAFELL
>NZ_CP012069.2|WP_050342720.1|219899_221006_+|4Fe-4S-binding-protein
MSDIADATTPAQRDARSAAGDAGDVKANRAEDGTARRSGQQVSPRKRRHSFVRWTRLGVQLVFLLLSPQAFSTAFSAARSIMVSLGKGEAIEMTGFTITLVALLVHTIVFGRFFCGYACAFGTLGDVLFQLGDAIRRKLRLRSLRVPDKVEDVLRLLKYLVLAALLAGSFLGAGSIISSASPWTAFGHLTSLSLGSMGIAGGIILLVLMVPMLLKERVFCEFLCPLGALFSLMPIIPRSNRHRNPHDLAGSAGCKRACPVRIYPPGEGRWMGECIQCDRCECVARPGCVTLGPALQRAEEALRHQGFACEARAACASGSQRPAAPRPSSYLFWHDYRTLRVAALALVLLGLLWLGGTLNYLPASPLVS
>NZ_CP012069.2|WP_050342718.1|219255_219888_+|FMN-binding-protein
MEHGPNKNLLVRSAVVAGTTLALAGFSTYTALSAARAQEAAQSQRNSGERGALLKDGTFTGAARSFGGVMHVSVVVSNGYITSIEVTGTGDNSPYFDRAKEKVIPAIVDRQSVSVDTVSGATFSSKGIMNAINNALVSAGAMEGQTARTNLTTSSSSKPHSTAELKKLAQQRAPEAPPWWEVTVDDLLGTNDDGTGGYNYTIRQGSGGTN
>NZ_CP012069.2|WP_050342716.1|217693_219091_+|Dyp-type-peroxidase
MSDSLEEGRERDEDGITRRGALKGLGAFAAGAVATVALSGCSSSSANGGATVEGTTSSLIETDVPVAANDWTDNGAYVRNVQRMSQKMRGVDHQPGVTSAQQNLQAVALDMTSTATRDDLIKLLKTWTTYAENLCGGYPVNGPNSDKNASPLDSGEVYDLGASNLTITFGFGASLFQTADGKDRYGLASIKPQKLDLTMPHFSGDQLQSDECGGDLFLLIGSEDPKVAFHAARNLIRAAYGTATIRWNKVGYYHTISPEGYAHADRDLFGFRDGTTAPSAEDEDYMNRDVWIQDGDDPNSALYKGGTYMMWRSFDMKIEAWDQQTLAEQERIIGRTKLEGIPLSGGEDETAEPDPSATDEDGNPLIDPKSHVGLFSSLRHSSGHTMFRWGWNFSNGFNAVGQLKAGMHTGGMVRDPEEDFYAFMRLWRDCDLTEYMSFTSSAVWLMLPGLQKDQTYIGQQIFEAV
>NZ_CP012069.2|WP_050342714.1|216219_217545_+|peptidase-M75-family-protein
MIKLNSGSWWRKATAVALAGALVAMPLAGCQSNSPSGSGGSGTSQTASDKSSNNIDVTITDDSCKLTANSAQSGTVTFTVTNKGTAVNEFEILAEDKLQIKTERENITPGTTVTVTAQLEPGTYYTASKTNMVGALVDATKFEVTDSGKEVKISDDEQQLREAAQTNYTSYVKDQSGQLLEATKAFAEAYKKGDYDTCRNTYAIARLHYERIEPTAEAFGDIDPYLDERRADAGDDGYVTDFSSYKPGTNLHEAKYWTGWHAIELDLWTKDSGYTNEFRAALADTLVSDTQSLYDLVYSNDFRVSLDEISNGAISLLEEVATTKITGEEEAFSHTDLYDFQANIEGAKVAYGDVRDLVKMKSPDTVDAIDKAFQQMESELAKYNTGTAEKPVYPSYTEIDANAGENQTDDKLSSGARSLSNQINALRESVAQLTSIVLKES
>NZ_CP012069.2|WP_083444066.1|215179_216157_+|FTR1-family-protein
MFVANFLIALREGVEAALVVGILIAYIYKVGRKDIMPKLWLGVALATVVPLGLGVWWTWGPYTITFQTQEILGGSLSIVAMVFVTWMIFWMGKNSRKLAQSVRTQAEEALDAGNVMGLVWLAIISVGREGAETAVFVWATVKSSGEQGIVGPAAGVLLGLVAAIVVGYLIYKGSVLINIHKFFAVTGYLLILVAAGIIMYGIKDLQEAGVIPGYAVYLYNYTDVITDVAGTWWFVLLRAFFNLDILFAPTSAQLAAWIAYLQVVLPLFTLQVWGVTFPNSGGSRGKWDDIPQIRKASTAPQDSEEASASQVAETSAVSQEEDRST
>NZ_CP012069.2|WP_050342710.1|211282_214981_+|thiol-reductant-ABC-exporter-subunit-CydC
MFNKRLLALVPTATRRSIVAAILRLLSLGCQVAVLVWLADILMDAQASLSADIAVPSACIVLQLAFGACAEAAGRRAGAAAVTTLTKEVFEKLIGSGTTLPSRMSEGEASQLVGEGAQRLRPYFQDYLPQLVFALLAPLGLLVLLLAVSPLAGVLMLAFVVLMPASIMMLMGRAKRFMGAYWDDYVDLSSAFLDAIRGLVTLKGFRADAGWQGRLARLAKEFRQATMRLLRVQMGNVLLMDLFTYGGIATGVVVATLQCAAGDISPSAALAIVFISSFFFLPMRRLGSLFHTGMNANAVCERIFALLDAEDQFATDEQVDLGGPGIACSNLGFSYDGKVKALDGVDFDVPAHTLIGVTGPSGSGKSTLIRAIAGGCVGYEGSIRVCCVELSRISCESLFSVVSVVSQQSHVFKGSFRSNLLLGKEDAKDSELWGALRNAQLDAFVLSSGGLDAQVAEGGANLSGGQRQRLCFARALLRDTPIYVFDEVTSNIDASSERKLLDGISLLSVTHTVIMVTHRLSALALADEIYVMDEGRVAERGTHPVLMARGGLYRRLWDRLADLETFAAQAGVEYDEDRYVPTDAELRVAKVVATHSIPLMGAQAMQAALEALSYRAYSSAPVAGLPKGHPAWIPLPDFGEPKAPADQVAVGTGGNNGSEEDRRQDSGLSEEKDDNPSRRSRLKTILSMLRLTRGMGKEVLLAALLGTLGDLCVVAQLALAGWAVWVLAPASAGPGAMSCLVAICTLALVRAALHYGERLLTHDQTFRTLALVRDRVFGALRRLAPARLVARDAGDLVLLLTSDVESLEGLYSRTLTPTASVILCSALTIAAVGSLAWQLGLVALVGIALLGIALPLVAGSLTRGRAERLSAYSVLMSSFVLDSLDGIFDLVQCGRARAYAKELETHAGSLEAGERPLGRAVALLAALAGILVTLVSCAMTVAAVALISRGAMSPGVGAACVLAVMADALIVADVSRLGFSLQRTLESANRIIDVMEEEPAVEDVPSGPGSHGNLVKGAVPVEARDVSFSYGKREVLHGLSLRVRTNALFRLTGPSGAGKSTLLRLIMRYWDVGAGSITVGGRDVRSIASDELRTSACQMTQDSYLLDATLRENLLIARLRASDEELGRAIDASALREVVDRLPQGLDTPVGMHGTALSDGERQRVGLCRALVSGAPLMLLDEPTSRLDSLNEAAVLSALRAAAGGRTIVLVSHRRVAAAIADETFVLQAKGR
>NZ_CP012069.2|WP_157051331.1|210576_211098_+|hypothetical-protein
MRFLSMVHSYSTLLLVYWCVRYNFSVPGLIPILVVNAVLSFVLAAHISSRKRRCTVPVEGELVLSEVREIPDSPSYGRGGKIQWVHDVWRYRWGDDVCFVEDTIPPLVGWFGPLVGIRRSGTIWVDPSRLPYTLYRGALTPDWIYHLRFYYATAALCLLLAAITAVTCVGRLT
>NZ_CP012069.2|WP_050342706.1|210253_210580_+|hypothetical-protein
MRRARGALLVSLSVAVVVVLGMVFSRVRVKITGQTLFPGVLQGNAGDKPSVLREDDTRRFTNSLNGLGAAVASPSNLGWNLAMSGPTPVSQWVSLVFGTLSGMGWAAS
>NZ_CP012069.2|WP_172674417.1|224834_225680_-|hypothetical-protein
MSGLRGADSLSGRERQVILMTLSGWPASAIAGTLHVSEPTVSSYRGRAYRKLKVKSLPELVARVRPLRRVAPIASLGRPLASGIRRVVALALVPCTTLVVSLCLGDRGVTVFSLVTCAMMATGVFSLHRARGTAGRDAHGAGTRDAEAAIALGSLCTLAGTRALGNSPTGPASALAGYLVLGTVGALVPLAARGGRDAALSDAMLACDERPRLYLLGRGLTQLEASVSVLTAEGVPAPGIASHLHVALPTVYSYRARGLGKLGLHGRGQLLELLRREAGMR
>NZ_CP012069.2|WP_172674418.1|225654_226650_-|hypothetical-protein
MSGKMMSQGRSGGSDDSHRPREGSHPWTTLLCPCAIAAGALAGAFPRLATTTVYVAIPPVGVTGFFAPTLVLAIGILLVAWDRTGGWAARGRNALVAHLLCLVFSVAFIVFELACLYLRGVLSEWNYVSVTPWMRCLELGWGTLCLLLLMLAVLLSPSSGTSRHLVAHSCQISTSVLVLGLASGFALALSSMDATTGGTVPKDARIVIVVAVMLCRFLWMILVTLLVPSPLSESLKGRWLPWGSLLAGHALGAIVRMLTEGTQAGFIYVGPAYHLTLLAASLALLVIALVVGRRASRRSAQPRTDREAARPKLPFAPQVYEKMLVGLAGGG
>NZ_CP012069.2|WP_050342731.1|227202_227490_+|ferrous-iron-transport-protein-A
MEAVIDDRAYVATEDEGTAPVRGAQLPLAMVSEGQTATVLKVRGSQDLRQHLSEMGFVPGAEIEVVSRVDGDVLVSVKGATFGIGREMAMRVVTA
>NZ_CP012069.2|WP_050342732.1|227658_227895_+|ferrous-iron-transport-protein-A
MATLKDVKVGQSATVARLSGTGAIKRRIMDMGLTKGTQVLVHKVAPLGDPIEVTVRGYELSLRKDEAECIEVTDVARA
>NZ_CP012069.2|WP_050342734.1|227918_230597_+|ferrous-iron-transporter-B
MTTEKQKLNIALAGNPNCGKTTLFNELTGSNGYVGNWPGVTVEKKMATWKADKNVTFVDLPGIYSLSPYSPEEVVSRDYVVNDRPDAVINLIDVTNLERSLYLTTQILEAGCPVVVGLNMCDLLKERGDVVDTKKLSQMLGVPVLEVSALRNTNLDELVKSGIEAAKKGDVPGGVSCFSSAVEAALDAISAAIKDKCKPELVRWYSIKLFERDADAIKALGLSSDELASLEGHIASVEKERDDDSESIITSDRYDWIATVMDACVKKAPKTLTRSQQIDRVVTNRVLGLPIFVGVMILVYWVALVLVGKPATDWVTDNLFGDGFFVNAQSAQQFEEADDAWKDNHYKDQISGYIAAAEDAGVSVDGVQDAVDAKEPTDEDKETISTFEDAASQAGVVATDVPATDEDGNFLDTDGNVISQVDADGNPVLEGGQQLQVVDKVTIDDFKTALDSPEPDQHDYDGFVDSIPHVVSGWLTGAGASDMVQSLVGDGIINGVGAVLSFIPQIFCLFVALCFLEDCGYMSRVAFVMDRVFRRFGLSGKSFIPMIISSGCGVPGVLATKTIENERDRRMTAMLTTMIPCSAKLPIIALVMGVLVGADNSAWWVAPLFYFMGIVAIIVSAVMLKKTRPFAGAPVPFVMELPDYHLPSLRSWLLHVWERVSSYAKKAGTIIFAAAVGIWFLSNFGIAGWEGGSGAFGFLQGMEGVPDGYMDYSILAGIGGALSWIFMPLGFGNWQATSSSISALIAKENLVSTFGVLYGLGDATEKSVSMWRGFAGMFTVEGTLHVGAMCAFVAFNMLCAPCFAAMGTIRRQMESARWTAFAIGYECVFGWVVGLLINQFYELIVFGSFGFWTVVAFVLCAAMLFQLFRPTPKWKEKDDKILDSLAGAGDTV
>NZ_CP012069.2|WP_050342740.1|230734_231040_+|hypothetical-protein
MGFHHQACIAAAGAAATAAVVRLAQRGVLHRGAVSVAACGIKLADVVRAETQSIIDDASDVTAEARRRVRIDAAVKERLAKEEGRIREEVTAEIDKAGADA
>NZ_CP012069.2|WP_050342742.1|231054_233163_+|heavy-metal-translocating-P-type-ATPase
MLYAIVSDIPGRLRLRCSTGTLDDKEAYGISHALLRLDGVSHAEVHVANASVLVVFEPSCRQRVLDAIGMLDVLALPREDGSIEPFAGQVELAAEKNRFILRVVRHVVSRYARKWLLPMPLRVAWTVLMGLSYIVNGFGYLTKGRLTVEVLDAMAIGASLARGRYWDADAVMFLLGLSNILEDHVQSRAHLALKEGLITRPQTAWAVIDGQDTQVSMSEVREGMLLRMGMGSVLPVDATVIAGEGSLDEASLTGEARLVHKGVGSTVYAGTALEEGELTVRVTAAPGEARIDSIATLVEQSASLKASVQGKAERLADSLVPLNLLAFFAIMAITRNVEKAMIVLMVDYSCAIKLSTPVAVMSAMGEASDLSVIVKGGKYLEALAAADTVVFDKTGTLTHASPQVEKVLAFGEMDEASVLRYAACIEEHFPHSMARAIVREARRRHLSHERELHAKVHYVVAHGISTHVGGDRMIIGSAHFVFEDEGVEKPDDLDERIAREAPSSSVVYLARERQLVGAICIADPLRDEAREVISRLRGLGVRRVIMLTGDSKAAAAHVASELELDDYHAQVLPEDKSSHIDALKAHGHTVIMVGDGINDSPALASADVSVALSDASDIARAVADVAVMDNSLESLVMMRVLSQRLMRRIGWDYRFIVGFNSLLIVGGVMGLVPVTTAAYLHNGTTLAVVALNTRRLLRKSET
>NZ_CP012069.2|WP_050342743.1|233396_233726_+|hypothetical-protein
MKQKLGVALSVLFISSACFAMGMMGAWVDPILMRQDVTRVGSQGASKLAGTPAEVASGYSTVQMGTHDASRAADVSSIENGLDPWLPIVVALSAGVIVIRLSCMRQDAS
>NZ_CP012069.2|WP_050342745.1|233830_234631_-|ABC-transporter-ATP-binding-protein
MLTLSRVSKTFNRGTASEKPALTTVNLTLEDGEFVTIIGGNGAGKSTMLNMIAGVYPLDAGTIELDGIDISQLPEHRRSRYLGRVFQDPMRGTAADMQIDENLALAKRRGEHRGLSWGIGKEERAGYAKRLASLDLGLEDRLESKVGLLSGGQRQALTLLMATLQKPKLLLLDEHTAALDPKTAKKVLSLTQQVVDEHHLTTLMVTHNMNDAIRLGSRLIMMHEGQIIYDVAHEEKQRLTVADLLQKFEEVSGGELTNDRMLLSEA
>NZ_CP012069.2|WP_050342749.1|234630_235587_-|ABC-transporter-permease
MQLALLGAASQGILWGIMVLGVFVTFRMLDIADLTVDGSFALGGSVAAVASVGLGLDPIVAILLGTLAGIVAGLVTGLLHVLFDIPAILAGILTQISLWSVNLRIMGKSNTPLLNADTIFTRVASLLNLTQTIATLAIGIVLALVIIVAMYWFFGTEIGSALRATGNNEDMCRALGIDVRVTKVIALALSNGLVGMSGALICQSQKYADIGMGTGAIVIGLAAIVIGEVLGRLTPGKLTAFGSRLVSVVVGSVVYFIVRAVVLQMGLDANDMKLLSAAIVALALATPVVLERHQLRRSYKRDNAASALPDDTAKGGER

Crispr_ID: NZ_CP012069_4

• CRISPR_ID: NZ_CP012069_4
• CRISPR_location: 253498-253583
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_4

Consensus_repeat	Method
AAGTGCCCCGCAGATTCTGGGGCAC	CRISPRCasFinder

spacers of NZ_CP012069_4

>4.1|253523|36|NZ_CP012069|CRISPRCasFinder
TTTGATCCGAACGCCAACTGGGCAAACGTTCTTGAC

CRISPR arrays and Neighbor proteins around NZ_CP012069_4

CRISPR arrays

The CRISPR arrays of NZ_CP012069_4

>merge|NZ_CP012069|4|253498-253583|CRISPRCasFinder
AAGTGCCCCGCAGATTCTGGGGCACTTTGATCCGAACGCCAACTGGGCAAACGTTCTTGACAAGTGCCCCGCAGATTCTGGGGCAC

>NZ_CP012069|4|3|253498-253583|CRISPRCasFinder
AAGTGCCCCGCAGATTCTGGGGCAC	TTTGATCCGAACGCCAACTGGGCAAACGTTCTTGAC
AAGTGCCCCGCAGATTCTGGGGCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342759.1|246366_247398_-|SPFH-domain-containing-protein	unknown	unknown	gnl|CDD|259800
NZ_CP012069.2|WP_083443716.1|253845_255147_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|372371
NZ_CP012069.2|WP_050344667.1|253078_253336_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083444068.1|250888_252589_+|Na+/H+-antiporter-NhaA	unknown	unknown	gnl|CDD|377746
NZ_CP012069.2|WP_157051334.1|245224_246031_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342774.1|256466_256778_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_CP012069.2|WP_050342783.1|267065_267503_+|6-carboxytetrahydropterin-synthase	unknown	unknown	gnl|CDD|376501
NZ_CP012069.2|WP_050342762.1|247578_248370_+|mechanosensitive-ion-channel-family-protein	unknown	unknown	gnl|CDD|366370
NZ_CP012069.2|WP_050342767.1|248987_249713_+|5'-methylthioadenosine/adenosylhomocysteine-nucleosidase	unknown	unknown	gnl|CDD|350159
NZ_CP012069.2|WP_050342772.1|255339_256371_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NZ_CP012069.2|WP_083443718.1|257771_260603_+|twin-arginine-translocase-subunit-TatC	unknown	unknown	gnl|CDD|376413
NZ_CP012069.2|WP_050342776.1|256899_257769_+|twin-arginine-translocase-TatA/TatE-family-subunit	unknown	unknown	gnl|CDD|224739
NZ_CP012069.2|WP_083443715.1|242591_245216_+|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl|CDD|273429
NZ_CP012069.2|WP_050342765.1|248502_248991_+|S-ribosylhomocysteine-lyase	unknown	unknown	gnl|CDD|376888
NZ_CP012069.2|WP_050342770.1|249773_250637_-|DegV-family-protein	unknown	unknown	gnl|CDD|273257
NZ_CP012069.2|WP_050342780.1|263600_264269_+|dTMP-kinase	unknown	unknown	gnl|CDD|234814
NZ_CP012069.2|WP_050342782.1|265441_267004_+|hypothetical-protein	unknown	unknown	gnl|CDD|224688
NZ_CP012069.2|WP_050344671.1|264296_265463_+|DNA-polymerase-III-subunit	unknown	unknown	gnl|CDD|379051
NZ_CP012069.2|WP_050342778.1|260937_263604_+|DNA-topoisomerase-I	unknown	unknown	gnl|CDD|235971
NZ_CP012069.2|WP_050342757.1|246140_246338_-|hypothetical-protein	unknown	unknown	gnl|CDD|227214

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342759.1|246366_247398_-|SPFH-domain-containing-protein	gnl|CDD|259800	cd03402, SPFH_like_u2, Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, and in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.	7.07322e-127
NZ_CP012069.2|WP_083443716.1|253845_255147_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|372371	pfam12897, Aminotran_MocR, Alanine-glyoxylate amino-transferase. These proteins catalyze the reversible transfer of an amino group from the amino acid substrate to an acceptor alpha-keto acid. They require pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze this reaction. Trans-amination reactions are of central importance in amino acid metabolism and in links to carbohydrate and fat metabolism. This class of aminotransferases acts as dimers in a head-to-tail configuration.	5.68529e-135
NZ_CP012069.2|WP_083444068.1|250888_252589_+|Na+/H+-antiporter-NhaA	gnl|CDD|377746	pfam06965, Na_H_antiport_1, Na+/H+ antiporter 1. This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyze the exchange of H+ for Na+ in a manner that is highly dependent on the pH.	8.33404e-165
NZ_CP012069.2|WP_050342774.1|256466_256778_+|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	6.04332e-22
NZ_CP012069.2|WP_050342783.1|267065_267503_+|6-carboxytetrahydropterin-synthase	gnl|CDD|376501	pfam01242, PTPS, 6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.	2.43648e-30
NZ_CP012069.2|WP_050342762.1|247578_248370_+|mechanosensitive-ion-channel-family-protein	gnl|CDD|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	4.74973e-24
NZ_CP012069.2|WP_050342767.1|248987_249713_+|5'-methylthioadenosine/adenosylhomocysteine-nucleosidase	gnl|CDD|350159	cd09008, MTAN, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases. This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs): bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.07107e-92
NZ_CP012069.2|WP_050342772.1|255339_256371_+|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	9.20793e-11
NZ_CP012069.2|WP_083443718.1|257771_260603_+|twin-arginine-translocase-subunit-TatC	gnl|CDD|376413	pfam00902, TatC, Sec-independent protein translocase protein (TatC). The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein is essential for the function of both pathways. It might be involved in twin-arginine signal peptide recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least two TatC molecules co-exist within each Tat translocon.	1.39828e-61
NZ_CP012069.2|WP_050342776.1|256899_257769_+|twin-arginine-translocase-TatA/TatE-family-subunit	gnl|CDD|224739	COG1826, TatA, Sec-independent protein secretion pathway components [Intracellular trafficking and secretion].	1.55279e-13
NZ_CP012069.2|WP_083443715.1|242591_245216_+|UvrD-helicase-domain-containing-protein	gnl|CDD|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP012069.2|WP_050342765.1|248502_248991_+|S-ribosylhomocysteine-lyase	gnl|CDD|376888	pfam02664, LuxS, S-Ribosylhomocysteinase (LuxS). This family consists of the LuxS protein involved in autoinducer AI2 synthesis and its hypothetical relatives. S-ribosylhomocysteinase (LuxS) catalyzes the cleavage of the thioether bond in S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of type II bacterial quorum sensing molecule.	2.01488e-76
NZ_CP012069.2|WP_050342770.1|249773_250637_-|DegV-family-protein	gnl|CDD|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	1.27302e-75
NZ_CP012069.2|WP_050342780.1|263600_264269_+|dTMP-kinase	gnl|CDD|234814	PRK00698, tmk, thymidylate kinase; Validated.	6.15784e-77
NZ_CP012069.2|WP_050342782.1|265441_267004_+|hypothetical-protein	gnl|CDD|224688	COG1774, COG1774, Uncharacterized homolog of PSP1 [Function unknown].	2.62617e-52
NZ_CP012069.2|WP_050344671.1|264296_265463_+|DNA-polymerase-III-subunit	gnl|CDD|379051	pfam13177, DNA_pol3_delta2, DNA polymerase III, delta subunit. DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.	1.25396e-52
NZ_CP012069.2|WP_050342778.1|260937_263604_+|DNA-topoisomerase-I	gnl|CDD|235971	PRK07219, PRK07219, DNA topoisomerase I; Validated.	0
NZ_CP012069.2|WP_050342757.1|246140_246338_-|hypothetical-protein	gnl|CDD|227214	COG4877, COG4877, Uncharacterized protein conserved in bacteria [Function unknown].	1.12969e-12

Protein sequences

>NZ_CP012069.2|WP_050344667.1|253078_253336_-|hypothetical-protein
MPGDTGAPEYGELQHLVDGLFEDDPKRLVSKIDVLVRADIEGICGDLREVVDLLPGGRYTRRRLCDQMNSIITAHGWGYSYGTVY
>NZ_CP012069.2|WP_083444068.1|250888_252589_+|Na+/H+-antiporter-NhaA
MREKLALGLRKAQALGSGATGGAEASAKTKRGKKAKKKAKAAKSKGQVEELAGTKDRDDGKDQSGTTEDQGGLEAHGGPGVPQASLERSEDQDSPERSSERPQRPSIIREPKVLRRLARRSALESVTSNGTVAAAVMVVAALLAVVVANSAAYEPLHEFLELPLTLGVGSLSASITLEGFVNDFLMAIFFLLVGIELKYEMTVGQLRKPRQAALPMLAAVGGVCVPALIYLTLNYGGAVHGWATPIATDIAFALGVMSLLGDRVAPATKVFFQTLAIADDLVAIVVLALFYGQTPDIAWVAASLIVVTVLAGMARARVYAARPYLAVGIVLWLCMYNSGVHATLAGVILAFCLPARSDVRLGGLRGWLGDQARILDDRYSDKHHVLGQHDFMASATYIERIMHHVTPPLQRVERSISVSVNYLILPIFAFVNAQVRLVGMDLSALLADRVALGVFFGAVLGKPVGIILTTWVLVRVGFARLPKRVTWNQVVAVGIMGGMGFTMSILIAGLAFPSPTEVMAAKCAILSASFMAGLLGIFHMRVAYPLVRSLRRRRRRMTDQRTGHVA
>NZ_CP012069.2|WP_050342770.1|249773_250637_-|DegV-family-protein
MNKQRIAIITDSGTDTDEDFRKEHDIRIMPLRIIYSDGSTFSSGIDISSDEVVRRFGEEIPTTSLPSPHEMRKVLEQARDDGYTKAVVVTIASALSATNQTARMVANEMEGFPVLVVDSKSIGIAAGMVVRRAVEYVEAGVPFEQLEERLTQSVERTDVFFAVKSLEYLYKGGRINSAIYRLGSILNIKPILTCSKEGYYTIAKKVRGWGKALDTIVGVVAEKANGFDRVRLALCCTKATSKVRSLLETRLRSQVRAEILEFLSSSLPPDLIVHTGPELVGMGVQGA
>NZ_CP012069.2|WP_050342767.1|248987_249713_+|5'-methylthioadenosine/adenosylhomocysteine-nucleosidase
MRLGIVGAMDSELAHLKGKLADVQVSRWTNMDFFAGTLGRTCAVIVRCGVGKVNAALCVQALADHFAVTHVINTGVAGSLDGAIDIADIVVSTDAVQHDMDVTSLGYAPGQIPDLDVLAFPADPALRALALEAVKVAAPAARAFEGRIASGDQFVHSPSQRERIASLFKACCAEMEGAAFAQACYLNSLPFVIIRAISDKADGSSNIDYPSFEKAAAERCARIVEQMAVLLGNATHRRGDG
>NZ_CP012069.2|WP_050342765.1|248502_248991_+|S-ribosylhomocysteine-lyase
MEKIASFTVDHLLLEPGVYVSRVDSWQGIDVTTLDLRMVAPNREPPMDTAAVHAIEHLGATFLRNDASWKERIVYFGPMGCRTGFYLVLFGLVTPREALPLIVRLFELIASFEGEVPGAQPKECGNWHDSDLAQARWWAKRYLKNTLRGIDDAHLSYPGQQA
>NZ_CP012069.2|WP_050342762.1|247578_248370_+|mechanosensitive-ion-channel-family-protein
MEELSDTTVMGLGLPDFVAKSIFVAVVIIATLLVQYVLVRAIRKALDNSNIPSASIFINIVRAILWLVALLSLMQPIFGINPTGLVAALGVGSVIISLGLQATVANIVSGLGLMLGKVVEPGDEVSISGFSGVVTDVTWRHTIVRARDGTEQVIPNSVLNTSALTQRTRWDVGDCEVSFVVQTGADLDEVEREVIGRGEAVLGDRLDKSIKSSVTFGEMDAAGITGHAHFHLKDGCAMGEARDKVVRSIAASPWLAGATPAEP
>NZ_CP012069.2|WP_050342759.1|246366_247398_-|SPFH-domain-containing-protein
MSTQTSCTEKKAHAKSGWMMIIVDVLLYAVSIELMVSSTISLSNEAEVGLFAVSLLTLFGSVLLLVVAIIVSNGFFTLQPGQARVCVLFGKYVGTVRDDGLHWANPFYARSLGRTSAPDDPAGALLTKSALTGLPTASGRSHVSKISLRARTHEGERIKVNDKMGNPIEIATVVVWRVADTAKAIFDVDDYEGYVSMQVETALRHVASIYAYDHLEDDDDSSTTITLRSNIEEVSEALKLELTRKLSVAGVAIEDARLTHLAYAPEIAQVMLRRQQADAVIAARKKIVEGAVSMVDMALSQLSDDGIVEFDEDRKAVMASNLMVVLCGESEAQPVLNTSSLYQ
>NZ_CP012069.2|WP_050342757.1|246140_246338_-|hypothetical-protein
MAARKQYPLRIDPAIWEAVELWAKDEMRSANAQVEFILRDALRRAGRLSKRHERTSPKQGDKHAD
>NZ_CP012069.2|WP_157051334.1|245224_246031_+|hypothetical-protein
MDRRSSHSTFGFPRGRAAHAAVTTAFVLVWAIVMGALGKDDPLMQPPQREGVGLQLIPVDLRVSVVSLLLWVIALLALSYVVGKRPRLLILSWQALAVPVICALVLTLEPWESLRWQAVEFFLGPNGRPAPALVSLLIMLLYDIARFLLKPLCVMVGLWLTTCVGDGERPRPASLAWGRLLGVSIGCGILSFVLTGLLEMVIPISLKAVQSMIVQAMSNGSDIPVRLAIWQDMLVQLVSVLAVVPALCVSPLKAKTEEAEEPEEAYLE
>NZ_CP012069.2|WP_083443715.1|242591_245216_+|UvrD-helicase-domain-containing-protein
MPSYNEFVSNLFTMEPIAPAATPASRPVTHHGAQQPLAGEQPDERSVSAGATIDLDSLNPAQREAVQTTSGPLLVLAGAGSGKTRVLTYRIAHMIADEGVHPWQVLAITFTNKAAAEMRERLGALLPGGTRGMWVCTFHAMCVRMLREDGERVGYPPNFTIYDDDDSRRLVKTIMGDLDIDPKQSPLPAIRSMISQAKNALVFPDEFDAQASSAQQHAAARVYRVLQRRLERANAMDFDDLLTKLFELLSKYPEVLDRYQERFRQISVDEYQDTNAVQYAIANLLARKHRNLMVVGDDDQSIYSWRGADIKNILSFRKDYPDATVVKLEQNYRSFGHILNAANAVVRHNSRRERKRLFTDRGDGEQIKLFQAADERDEGRWIGAEIEKLHDAGTSYDDVAVFYRTNAQSRTLEDMFLRAGVPYRIVGGTRFFDRAEIRDVVAYLKLVVNPGDDVSALRVVNTPRRGVGTTSVRAVQAYAAEMGLSFLEAAASCAREPGIVGPKARRGLAEFTDVIESARRYAGELSRVIEAIVDKAGIIRVYEAEQSVDADGRIENVREFFSVAQEFDETHDDATETLESLRQLRAAGMLGVGGGGDGATDVAVLEVAGERVDEAEVEPSGGSEVAAGAVAATAAGAPDVAAEKLPAFLEWLALRSDLDSLDGQTSAVTMMTVHSAKGLEFPVVFVSGMEEGIFPHHGDRQEDPARIEEERRLAYVAITRARERLYLTYASTRHLFGTVQNNPRSRFLDEIPEKDVHAIGVGSSDFSGVGWEKRGDRHGTYGSGRGSEVYGGRVFGSHTRSTGVRSAHSRPSPAKRDESGTKENFAVGDRVSHKTFGPGVVRAASGDTIEVLFSRTGKVKRLLKSFAPIVKIEG
>NZ_CP012069.2|WP_083443716.1|253845_255147_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MSKTMRRNAYELMSDEELERAIATLERQVDDIRAERLSLDMARGKPSPAQTALSRPMLDLVNSTASLSDGDAIVDNYGTPEGLPSARALAAEILGVKAENVVVSGSSSLNLMHDLVAHAFTNGVAGAEPFYRQGDVIWLCPSPGYDRHFKITEDLGIKNVVVPMREDGPDMDLVQRLVEDDPKVKGIWCVPKYANPTGVTYSDEVVRRFAALRPAACDFRIYWDNAYAVHCFGEKDDVLLNVFDALAEADADNLVYEFGSTAKMTFPSSGIAFVAAGDEDIKRVRAAFAVERVSSEKFSQLAHPRFLKNLAGVKAHMAKHAKIVGPRFALVEQKLTDGLAQLGVAHWSHPHGGYFVSFEGQEGSAKRTVALMAELGVKLTSAGATYPYGKDPADSNIRIAPTYPSLDDLRKALDVFVVAVKLVSAQLARESRA
>NZ_CP012069.2|WP_050342772.1|255339_256371_+|tetratricopeptide-repeat-protein
MASRRNRRAGGAAKAKRTAGSEAADKRTDNSSDLSGNPNRKRLARAKVVKGGKDGKKRSVFKPTIVDRMGGKKRTKEIAVAVFAVIIGVSMMLPSLAYIFTGHGPSGQGSNSSQSSDSTNSSESAGDDGGSTDSGNTDSSNEGAKNDIASIDDRYQKPISSLEDKLASATDDTSKLPTLLGLGDDYLQWALAASRQASDDAGKAHVSELYGKAIDYYKQYLAINDSGAVKVKISQCQLYSGDTDAAVQTLEALTQASPDYGPAWVYLGVTYVQKGDNTKAINALKRAEAADPNDEYGAKTLAQKYEEYLASRSNPSGSTTGATGSGSSGGMSLVDRLNSGMKL
>NZ_CP012069.2|WP_050342774.1|256466_256778_+|STAS-domain-containing-protein
MSIAITTSEGVGATRVACAGEVDVSNASELRDALNQALEGAPQTLEVDLSAVSYIDSTGIGVLVGVAHHAKDESVVFKVLRPQRNVERIMGILGVDAELGVER
>NZ_CP012069.2|WP_050342776.1|256899_257769_+|twin-arginine-translocase-TatA/TatE-family-subunit
MFGIGETELVIIVTFAFLLFGPDKLPGMGRTIGRVLRQFRDAQEGFTKVVQSEVLDPLNEAMGDAGAQNGTKRTAALEEDADRKSKSTGKSVPTKGGGKTFAERKAQAKTKDRKAVGTGGEQRGGVDASALYQNTKEKHPSSRKGSKESGGSAPMTVGDVGAPASVAVRPTTTVSTSKRLCLLMGTFGRPQAVSVPKRPSAASTLTSARLCLLTVAMPPHHLTTTPPSQLALASTRRRPQVASTCLTPPTSRRRRLLAAMAPARCLAVASPERLHPPTIPMSSTTGEGE
>NZ_CP012069.2|WP_083443718.1|257771_260603_+|twin-arginine-translocase-subunit-TatC
MPIGPARMPLMDHLGELRRRLAIVAVSLLVTSVVVYVATPTLIDIMLDPIRDVFESNELTVLSVLGGFTIRFKVAFFFSLIICTPVIVWEVMGFFLPALKPSERRWVIPTVAAMILLFFLGMGFCYLVIQKPTIGWMVAQSRAIADVIPEAEDFLNIMMLLEIGFGFAFQLPLIVFYLSILHVVPYKTFRSQWRYVYIVLLVISSVVTPDASPVTMILMFAALIALYEIALLIARFVLIARDGKESLKWSREEYQEYGDSIRPHEGDKGGTVDARAAQDSDARRGRGIALGHPGLTVLRLVALAACLVFAIMLATAPPREAPRVGTIGTGCSYELDTWSGTLTIYPTDGASGEMARVRDALSDDGDLLDAIRSVTVKEGVVAPADSSYLFGSLRAMESLDLSGLDTSRATDMKGMFQSCGSLRSLDLSGLDTSRVTDMEDMFSICLSISSLDLSPLDTSQVTNMKDMFSNCFSLRSLDLSPLDTSRVTDMWGMFQGCSSLRSLDLSPLDTSQVQYMGYMFSNCSSLSSLDLSPLKTSRVTDMGGMFWGCSSLSSLDLSPLDTSRVTDMSSPIGFGMFEDCSSLSSLDLSPLDTSQVTKMSGMFRGCSSLSSLDLSPLKTSQVTDMSGMFKGCSSLRSLDLSPLDTSQVTDMWGMFADCSSLRSLDLSPLKTSQVQSMGGMFDGCSSLRSLDLSPLDTSQVQHMGYMFADCSSLASLDLSPLKTLRVESMWYMFSGCSSLRSLDLSPLDTSQVKNMKDMFSGCASLRSLDLSSLKTSRVMDMSDMFDGCSSLRSLDLSRLDTSKVTRMDFMFSGCSSLASLDLSRLDTSKVTRMDFMFSGCSALASLDLSGWDTSEVTGMWGMFFGCSSLSSLAVGEGCGGVLSADRHTALPAGVGSRGWYSERDKRWLTLGELSSSRQGVADTYTAPEAWRSLVSPQAAQTSP
>NZ_CP012069.2|WP_050342778.1|260937_263604_+|DNA-topoisomerase-I
MKLVVTEKNDAAQQIARLLSSVGKPKAEKVYDTPIYRFTHDGEEWVTIGLRGHIMAPDFPRELRYSKAEGWFAVSEDGELLSAAVPDALAKPPYDSKRKPFLADGIDIKGWKVPSLPYLVWAPIEKLPAEKGIIRALKNLAKKADSIVIGTDFDREGELIGSDALRQMLEVAPDAPVSRARYSAFTKAEIDHAFANLVELDQDLADAGESRQYIDLIWGAVLTRYLTMARFGGFGNVRSAGRVQTPTLALVVEREREREAFVPEDYWVLSGMLAPKGVQDEEQRFRATHATARFKDKAAADAAYARVKDARTATVSDIERRRFTTRPPAPFNTTSLQAASSSVGLTPARTMRVAESLYMDGLISYPRVDNTVYPPSLDLRACVQSLTGVPQYAPYCRELLSAGKLVATRGKQETTDHPPIYPTAAADPDKLDAAAWKLYNLVARRFLATLSKASVSESTKLSLDVAGEPFNASGVVVVEEGFRAIYPFGQKKDKVLPALAVGDDCDVHSMELDAKQTEPPARYSQGRLIQEMEKRGLGTKSTRASIIQRLFDVKYLKGDPVEPSQLGMAVIKALTAYAPHVTSPDMTSELEADMTKVAEGTDSQEQVVMHSRALLSGMVDALIEHKDDLGEAIADAVTADAKVGSCPSCGKDLVMKRSAKTRGSFIGCMGWPDCDVTYPVPSNVKVEPIEGEAGVCPTCGAPRIKCKPFRSKAYELCVNPMCETNREPDVIVGECSKCKGEGRHGDLVAHKSEKTAKRFIRCTNYDECKVSYPLPQRGEIHATGETCPDCGAPIVEIVTARGPWRICVNMDCPSKEKKTASGRKAASGRTGTSGKKAAPSRKAASAKTGTSGRSSRATANRRKTGTGAHKPGTKRAAKRSGSAEDSKS
>NZ_CP012069.2|WP_050342780.1|263600_264269_+|dTMP-kinase
MSKRRGSFITFEGIDGSGKTTQARRVADLLGAAGLDVVLFRDPGGTVVGEQIRAILLDSTYATMSDACELLLYEASRAQLVSEAIRPALERASVVVCDRYFDSTYAYQHGGRGLDEDLVRRCNELGSCGVVPDLTLVLDLDVSTALMRTEGRDPDRLEAEGLHFQERIRESYLRLAKCEPARVRVVDGDAGEDEVFSHVVTQLVEACPQFCSALGEDARPSS
>NZ_CP012069.2|WP_050344671.1|264296_265463_+|DNA-polymerase-III-subunit
MCATAADCVASTVSPQALQVLDQQPRVRDYLAKAYGEGRISHAYLFVGAPGSGMHDAARALAQLIVCPHGGDASCDECIRVAHRTHPDVRYLKPESATGYLVSQVRELIDDAALAPVRAKGKLYILDDAGLLRDASANALLKTIEEPPRGVHFVLMARSAAAVLPTIVSRCQQLPFRVVSPGVAERAVELASGSCGGDARIALAVTGSPGRAAEFLASPDRQQARREVVRALDELARDDMWDVLISARRIVDAVRVPLDEYKLSQQASLKERADYLAPPAMRRIEAANKRELTARQRSGMMEALAVAESLLRDVLIRREGVDESLVNEDAADVVDRMAQASTSEAVIRALGCVSGAACDLAHNVTPQLVMETMLLSVKEALACPPSYR
>NZ_CP012069.2|WP_050342782.1|265441_267004_+|hypothetical-protein
MPTVIPVKFKYVAHDLWFDPADTGAGEGDYAICATERGQEIGLCTMDAMEVDEERLRQRIDKASLSSVVRIASESDLDRADKLARQGEDALPTFRDSVYKLNLDMKPIGVEYLFDGGRVVCYFSAEDRVDFRQLVRVLSRELRKRIDMRQIGVREEAALVGGFAHCGQELCCARLGCRLEPVSIRMAKEQDLPLNTSKISGACGRLMCCLRYEFDAYKDFKQRAPKRNAVIETPLGKAKIVEYDTPKEQICLRLENGKQVRIPLAEMQTSEAAVKKSEELHCPCRPDMVPRSALERLQSPEVQMALAELDRVHGVVPKAAFDSADIFVESKPRRRSRRSRRQDGSMSGAQGADGARSTFHPRGAKSAPTPREGDEPSARTQNRSKRRRKKGGVGGVSGGSPTKERVQETPVKSDARHRRRHHEDGDVSDGAVWPATTLVRSDGAGMPQDRPVRRRPGDRGGQQAKVQTRGQDGQRTQAQGTGTHEGTSKPKRRRRSGRGRGSGGGGLGTQGPGSDPSSAT
>NZ_CP012069.2|WP_050342783.1|267065_267503_+|6-carboxytetrahydropterin-synthase
MYELSTEHCFDSAHFLTDYHGACENLHGHRWRVTAYVAADELVTSGTERGMVMDFARFKRIVREECDALDHSFLVEEGSLRPETIAALEGEGFVLTLLPFRTTAENLARYLAERLIARGLPIRRVDCDETPNNRASYVPPSCAFE

Crispr_ID: NZ_CP012069_5

• CRISPR_ID: NZ_CP012069_5
• CRISPR_location: 342521-342780
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NZ_CP012069_5

Consensus_repeat	Method
GACCTCTCCGGTTGGGACACCTCGAG	CRT

spacers of NZ_CP012069_5

>5.1|342547|52|NZ_CP012069|CRT
GGTCACGGACATGGGGTGGATGTTCTACGGCTGCTCCTCCCTCGTCTCCGTA
>5.2|342625|52|NZ_CP012069|CRT
GGTCACGAACATGTCACGCATGTTCCGCAGATGTTCGTCGCTCAAGGCGCTC
>5.3|342703|52|NZ_CP012069|CRT
CGTCGTGCGCATGGATGAAATGTTCTCCCGCTGCTCCTCGCTCGCCTCCCTC

CRISPR arrays and Neighbor proteins around NZ_CP012069_5

CRISPR arrays

The CRISPR arrays of NZ_CP012069_5

>merge|NZ_CP012069|5|342521-342780|CRT
GACCTCTCCGGTCTCGACACCTCGAGGGTCACGGACATGGGGTGGATGTTCTACGGCTGCTCCTCCCTCGTCTCCGTAGACCTCTCCGGCTGGGACACATCACAGGTCACGAACATGTCACGCATGTTCCGCAGATGTTCGTCGCTCAAGGCGCTCGACCTCTCCGGTTGGGACACCTCGAGCGTCGTGCGCATGGATGAAATGTTCTCCCGCTGCTCCTCGCTCGCCTCCCTCGACCTCTCCGGTTGGGACACCTCGAG

>NZ_CP012069|5|1|342521-342780|CRT
GACCTCTCCGGTCTCGACACCTCGAG	GGTCACGGACATGGGGTGGATGTTCTACGGCTGCTCCTCCCTCGTCTCCGTA
GACCTCTCCGGCTGGGACACATCACA	GGTCACGAACATGTCACGCATGTTCCGCAGATGTTCGTCGCTCAAGGCGCTC
GACCTCTCCGGTTGGGACACCTCGAG	CGTCGTGCGCATGGATGAAATGTTCTCCCGCTGCTCCTCGCTCGCCTCCCTC
GACCTCTCCGGTTGGGACACCTCGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342884.1|341688_341952_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342898.1|354377_355031_+|ABC-2-transporter-permease	unknown	unknown	gnl|CDD|379133
NZ_CP012069.2|WP_050342890.1|350490_351003_-|YhfC-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|337619
NZ_CP012069.2|WP_050342905.1|356358_356751_+|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224639
NZ_CP012069.2|WP_050342875.1|334859_336062_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_172674424.1|336231_338511_+|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|238119
NZ_CP012069.2|WP_050342880.1|340440_340722_+|hypothetical-protein	unknown	unknown	gnl|CDD|227708
NZ_CP012069.2|WP_050342862.1|330239_332708_+|hypothetical-protein	unknown	unknown	gnl|CDD|274008
NZ_CP012069.2|WP_050342896.1|353662_354385_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
NZ_CP012069.2|WP_050342900.1|355504_355846_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342870.1|333001_333541_+|pilus-assembly-protein	unknown	unknown	gnl|CDD|377921
NZ_CP012069.2|WP_050342888.1|348734_349529_-|hypothetical-protein	unknown	unknown	gnl|CDD|274062
NZ_CP012069.2|WP_172674425.1|338858_339770_+|hypothetical-protein	unknown	unknown	gnl|CDD|226400
NZ_CP012069.2|WP_062393059.1|333612_334194_+|pilus-assembly-protein	unknown	unknown	gnl|CDD|377921
NZ_CP012069.2|WP_083443731.1|351312_351792_+|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|273625
NZ_CP012069.2|WP_050342894.1|351794_353462_+|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl|CDD|223733
NZ_CP012069.2|WP_172674423.1|334220_334838_+|Tad-domain-containing-protein	unknown	unknown	gnl|CDD|379164
NZ_CP012069.2|WP_050342906.1|356747_358118_+|hypothetical-protein	unknown	unknown	gnl|CDD|226657
NZ_CP012069.2|WP_050342882.1|340721_341561_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083443732.1|355041_355479_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|376540

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342898.1|354377_355031_+|ABC-2-transporter-permease	gnl|CDD|379133	pfam13346, ABC2_membrane_5, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	0.0084512
NZ_CP012069.2|WP_050342890.1|350490_351003_-|YhfC-family-intramembrane-metalloprotease	gnl|CDD|337619	pfam10086, DUF2324, Putative membrane peptidase family (DUF2324). This domain, found in various hypothetical bacterial proteins, has no known function. This family appears to be related to the prenyl protease 2 family pfam02517, suggesting this family may be peptidases.	8.28269e-16
NZ_CP012069.2|WP_050342905.1|356358_356751_+|GntR-family-transcriptional-regulator	gnl|CDD|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	6.45326e-30
NZ_CP012069.2|WP_172674424.1|336231_338511_+|VWA-domain-containing-protein	gnl|CDD|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	2.14095e-11
NZ_CP012069.2|WP_050342880.1|340440_340722_+|hypothetical-protein	gnl|CDD|227708	COG5421, COG5421, Transposase [DNA replication, recombination, and repair].	0.000131323
NZ_CP012069.2|WP_050342862.1|330239_332708_+|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.47519e-22
NZ_CP012069.2|WP_050342896.1|353662_354385_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.39348e-60
NZ_CP012069.2|WP_050342870.1|333001_333541_+|pilus-assembly-protein	gnl|CDD|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	5.83284e-09
NZ_CP012069.2|WP_050342888.1|348734_349529_-|hypothetical-protein	gnl|CDD|274062	TIGR02274, Probable_deoxycytidine_triphosphate_deaminase, deoxycytidine triphosphate deaminase. Members of this family include the Escherichia coli monofunctional deoxycytidine triphosphate deaminase (dCTP deaminase) and a Methanocaldococcus jannaschii bifunctional dCTP deaminase (3.5.4.13)/dUTP diphosphatase (EC 3.6.1.23), which has the EC number 3.5.4.30 for the overall operation. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	2.19903e-07
NZ_CP012069.2|WP_172674425.1|338858_339770_+|hypothetical-protein	gnl|CDD|226400	COG3883, COG3883, Uncharacterized protein conserved in bacteria [Function unknown].	1.6737e-06
NZ_CP012069.2|WP_062393059.1|333612_334194_+|pilus-assembly-protein	gnl|CDD|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	5.0526e-11
NZ_CP012069.2|WP_083443731.1|351312_351792_+|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	gnl|CDD|273625	TIGR01439, Uncharacterized_protein_Mb2626, looped-hinge helix DNA binding domain, AbrB family. This DNA-binding domain family includes AbrB, a transition state regulator in Bacillus subtilis, whose DNA-binding domain structure in solution was determined by NMR. The domain binds DNA as a dimer in what is termed a looped-hinge helix fold. Some members of the family have two copies of the domain in tandem. The domain is found usually at the N-terminus of a small protein. This model excludes members of family TIGR02609. [Regulatory functions, DNA interactions].	1.11776e-06
NZ_CP012069.2|WP_050342894.1|351794_353462_+|AarF/ABC1/UbiB-kinase-family-protein	gnl|CDD|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	3.24677e-125
NZ_CP012069.2|WP_172674423.1|334220_334838_+|Tad-domain-containing-protein	gnl|CDD|379164	pfam13400, Tad, Putative Flp pilus-assembly TadE/G-like. This is an N-terminal domain on a family of putative Flp pilus-assembly proteins. The exact function is not known. The Flp-pilus biogenesis genes include the Tad genes, and some members of this family are putatively assigned as being TadG.	0.000121976
NZ_CP012069.2|WP_050342906.1|356747_358118_+|hypothetical-protein	gnl|CDD|226657	COG4194, COG4194, Predicted membrane protein [General function prediction only].	1.146e-07
NZ_CP012069.2|WP_083443732.1|355041_355479_+|helix-turn-helix-domain-containing-protein	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	4.67152e-12

Protein sequences

>NZ_CP012069.2|WP_050342884.1|341688_341952_+|hypothetical-protein
MGLGSSSSIPHQAVAGAPPVTRDSGASGYVALGDGRLQLADLRVFGLGDTGVTERHVREGHRPHVCEVTGRQRDIFDRLGYGLSATS
>NZ_CP012069.2|WP_050342882.1|340721_341561_+|hypothetical-protein
MGVPTSLGLYADAVDGHGTEPRTRRNLDPSTGLYGMRLAHGWGYGEARPRGGDVAGARRRGYTCLFFDAPRAAEAERRLAGLLRELASELAAGNRVESHERYYDRYFEVRSGRPVGRDAAIAAAAARAGYFALFSNEAMGPFEALAIYRDGDAIERRLGDARSLLGSRTPPAPAEDTLAGRLFVAFVALVLAAWLRRRMRETGLDDDHTLEGLLDEVEAIERHAREGHRPRVLGVTPGRGPCSSAWATILPPRHESLGMWEPWAICHLPCRRERDRRAS
>NZ_CP012069.2|WP_050342880.1|340440_340722_+|hypothetical-protein
MSSCFEALARVRWGRDEEDVPLPQADLAMLVGGEGGVPLCYRRVAGTMADVPAVGALIRDMGPSLAGEVRLVMDRRFWSAANVNAMMEGTSSS
>NZ_CP012069.2|WP_172674425.1|338858_339770_+|hypothetical-protein
MKLEQAQREVDEGQHKLDELNARLQDSRARFSKSMSVSYKLQQDSMGLLDLLVSSDSLEDVIEYVQYSNAISYRSEREISELLEASKELAAAQSDLEARRDDATKARQDAENALNEAEAARTAEQNAYMAKQAALAEQEKAALEEAARAGTDATFQTENGNDSLVRTPTSGAVPAIFGVNWNMGREEFISHWAARIDAFLSGFPLAGHGRTFAEAAYDHGVDPRLSPAISNVESTRGTYCFLPYNAWGWGHMSWPDWDTAIRAHIAGLAAGYAPYLTVATANKYCPPNAAYWYATVLWGIEHI
>NZ_CP012069.2|WP_172674424.1|336231_338511_+|VWA-domain-containing-protein
MAPTKAEAKRLNVKLEITNLDEHPEIKDTTFHYVCSFFRWNDWVTSGWRLSDSTGNWTWSNYKQDNNPDKEWVAGPNDRPDGYWHNLDLKPGQTQSVDARDASCFYFYPVISPFSPRTDPALSLVDLQPAGNTWWISYNDRGYGPRSIVPFNFGGFPSDNDGTIILRMRYTPGLPKPPAPKFNLALKNQKQIDWLGDNKPNSDTTYKGINDYRLYLTSKTVDNTDYGTEKKKNIIFAIDISQSMRYEFNGVDKGQDTRWQSVKSAVDRLINGLGDDANNRFSIVTFSSDDWYSARFHGEGTYIRKYGNTSLMTAAQARSVAAGLTHAQSGGTDYSSAFRRIDECCQNPNDGWENIVLFITDGEPTSVPKDELRNLMGATAQAVIATAYTREAAKEHLGQVKSFFSIFVGTNQGTAAVLSMITQATNIAQNEKGSVQASNDKEMQDLINLLTRRIKKPDIGVAIKDQLSQYVDFYPGSQKVVATEKGGSPRTLSLSEYSFEYDGVTKTVTAKINKPATKDTTYVLSFDVHSNQTALDEWRSNPGYPDTGDLETDYADNKSSSGKEGFFSNAKAVGQITFDLGAGEQSVDYPFPKPVVQVFDNNNKGGIIKGHVTLFNQQLDAGKFTFGLYDCDDSADHNIKERHKFIDAGGLPVDVKNQSTDKDNGWFSFPTINYKEEGTYWYKIKQESIPGDLDGDQISASTKIKYDTHEALVKVMVTKEDGSFVARVEYDPKDYPDDASEEDKAAYFYNTYGVQGTYQ
>NZ_CP012069.2|WP_050342875.1|334859_336062_+|hypothetical-protein
MVNIDINIPVDRRTAIAAGAGLVAVVGGLAYCALRPSIKVVCAESIAPAMRAVGDKCPFALSIIPVADGDCTADKVSSLASSRGADVIIWKNNAPFEDLDGSSLGNLQSIATDISAGLSYAVNTQAEVKSLAICADAPVAVFNDELVKVMDGELLGELMQFVLMCRDLRDRYPAGVFGIEDSEADSWGLAACIDYFAAAVPDIDLTTIQVTDGAAGDGDEQGAGPFSEFPLRHYFIQPEDKAAQSPAALESGFKEGAYPVALMRFSSYASLKTSGISCDAVRLWGTYDITRPVLYPAYSVSVPSAVSDAAANFIKWLLGAKGQGALCGSVSYVPGGRSSEGISLANDLFGSVLSTGEEQSAEADDSDQSSLIYASPSWMSKISATSRERYMEAARKAITS
>NZ_CP012069.2|WP_172674423.1|334220_334838_+|Tad-domain-containing-protein
MFKQVHVLRSTAIGADGAPEDGESGNILVMFACSLIVLIFFIGLTVDVSMILWQKGQLVNDAQLIKNNRFVYQDSVRYADNPGEEFEKRALKTLQLNGYEGDGKIYFYEYSQKKEERKVKVRVELNKKANTYFFQVFGVKSIPISTSIDFEDTYGDYREKPSDPTKPENRVWHPKKSASEYNGTYEFNSTSASTGRTSEHLPSDF
>NZ_CP012069.2|WP_062393059.1|333612_334194_+|pilus-assembly-protein
MIEILRRRWADTAKRRTSGQALVEFVLVFPLFITILFAIIDFGWMAYQKAAFDYSRIHTSWDYAGLDVGNPSSTTFNWSYEKTGPTESSNTYDDTRVQTAVMESIKKAPSIGFDTHELTVTNAKVTISNVPSESTVPDRKGGATKATRVTRQARLEATVKYNVKPIIGLLIQPVEVTENIDVTHVVGDQTRTY
>NZ_CP012069.2|WP_050342870.1|333001_333541_+|pilus-assembly-protein
MRRLRFLRSVIAEEDGQEIVEFALIVTLLIVLLAVPIDIFRYVNTRMILNDAATDAVSSLNNDSIEHNTCESDVLKSVQKSYGSRLTDVKVDKINVQSIETKDPYTYHVFNSDKQNKTQYSDQFDPRDSNYYYKEVSLTLSCTENAITPFGGMFFGGSMSWTIKSDPVTCNVYTAGYKK
>NZ_CP012069.2|WP_050342862.1|330239_332708_+|hypothetical-protein
MANSAFRLVDDDFDFEDLDEIDDIDLNGLANPEDDGATAGAPEASTGEAGYGGNVDYANNTGYANNTGYANNTGYVDAGYAGDAGMGGEGDANVPMPTMSDNMEGTHSFFLEPNPGFDTSMFADPAAPAAPVPAQADENLQAEVLGDGTLENLDGVLEKSLFNGYSRKSVKEYVDSLNNNSKMIRTSFEKQISDLSKERADLSNECNVLRAQIDEIEGKKRELEDHIAATEREDREQDDRINDLMSTVDESRRQAEEALARVEQMKGERAAREKALSENEAELDKLRKDVQSKTEEINSLDRELGSFKDRVKYYSGQLDSYRNEVNEYKQKLLDFTQKLSEHEKVVSDANALRSQVAELQESVKGYEESTTELNARLKELYQSNEAYQQKNEALEGQVQTLSRKNDTLQGRVSDLQQRNSSLSSLVKKLSDDNSLALKRISSLEQRNNGFVSQIDKLRADSEATVSRLSELEEQNDSYVAQLDKLRSVQRESEAIINKLRYQNEDYVTQIGTLKDKTAEFESRASELQERNDGYATQISKLQDARDSSEARIRELQEQNKDFASQIGSLKSKNATSEARLIDLQEQNEASAARLSRLQEQNEASAARLSRLQEQNEASTARVTRLKQKNDDYVSQIGSLEDKNAASEARVFELEQKTDDYESQIDELKDQNEASNLQVAELQQTNKGLRERIAAVIEQVGDAKKKLEVSESELGKTLSYAASLEQQCSELIEHLNKMKEKCDLLTSKNKALLDLADKYRSQVEQHRSALQRIEQYGYEVNKFQHSTRVLFDAVGVQLDDGTDEFGSTPYEAQDDADEDFGEF
>NZ_CP012069.2|WP_050342888.1|348734_349529_-|hypothetical-protein
MLLSDGEIRELIERDVLVNADKNNVGTITCDLRTKRFVFSDGLSRASCKLQHGDSAFVECVEGVKLPHTIAARVLLKNSRIREGLTLDAPLYFPGHRTVVYYRVTNVSADTITLCSTRPIAQIAFERVEKPVDNAYKGTFQDEMEFRGMGRYEDVYREEIKQVESTADEIKSVERRMYGNVMAIMAILAGIFTLVNVNAQAMQADLKTVLTLNLTTVGSFSVLVALIGVVTGNVKGGGKGSICITCAIAVLCFVAAIACATQLP
>NZ_CP012069.2|WP_050342890.1|350490_351003_-|YhfC-family-intramembrane-metalloprotease
MHMGGAWRPSGTRHPRLRPFAMVVAAVISFGAPIGALVVARRRLHVQFKAVLVDVLVFVVFAGLLEQLAHALAFATFPGLRSTPVAFVPYAALAAGVFEELGRSCGFMLLLRSGKVDHDLPCAIRYNIGHGGIEAMMVVGLWPVGRHGPMVPLGSIGFSPSGQLLVGMSA
>NZ_CP012069.2|WP_083443731.1|351312_351792_+|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein
MRVRQHTMTREVATMYATHHHRHGAGPQGGRDRRGNGYFGPRGPHGNHIMGTVTVDGRGQLVVPREARDALNIQAGDRFVVFGNERRRSLHLVSADYFDSFADMLLSRSSRLERLARDLRGMSWGEGPEEDEGAGEGAGARSTDGDASRSTPDAGRPKE
>NZ_CP012069.2|WP_050342894.1|351794_353462_+|AarF/ABC1/UbiB-kinase-family-protein
MDRGRYGRVVRLFTRFGLELWWLDAGRRLRSAGRQRRLEHRTYARQARRFREVAEGLGGLIIKLGQYLSVRVDMLPREYTEELSALQDNVPPVPFEDIADVFEKSVGATVGEAFATFEREPLAAASLGQVHEATLVSGQRVAVKILRPHIAETIETDLAALKTIFGMAQRYTRLGDTIDFDQLYGEFERTVSAELDLMREGRSAEAVREKLHDFPNAAVPDIHWETSSSEVLTMEYMEGVSISDIGALDAMGIDRAQLATDLIDVFAEMILYDGLFHADPHPGNVHVQADGTIVLLDFGMMGTITDDMRKGFMGVVTAIFSRDAASLVDRLGDLGFIRPGTDTEGFTKAVLALLGHLDVGDPDKAISTLENYSDELRDFMYEQPFQLPANVAFLGKAVATVAGICQRLNPDIDFVSELTPLAQDLVGGEGRADGPSGLLSQLKDMGEAAIPALGQLPGLIERASSGRLVVRLSRTQVSALTDGQRSDTDRMTRAILGAALFVPGALCGMAVGWSPLAVALFVMGLVLMVYQACPARRKGARGRRGHSSWLRRSDA
>NZ_CP012069.2|WP_050342896.1|353662_354385_+|ABC-transporter-ATP-binding-protein
MNIVTVRGLTKAYPGFTLDAVSFSLAEGRIAGFIGRNGAGKTTSIKSMLNLTHPDRGEIDYFGLPLAGNEAQIKKRIGYSTGTISWYPRKRIRDIKSVMKLFYDTWDDAKYEGYLRTFALDEGKTPHELSEGMKVKCNLLFALSHGAEALILDEPTSGLDPFSRDELLGLFDQIKHMGVAVFFSTHIISDIERCADDIVYISKGRIVACVPKEEFADRYQKPGETLEESFLRLEGGMRNA
>NZ_CP012069.2|WP_050342898.1|354377_355031_+|ABC-2-transporter-permease
MRSLLIKEMRLSASVLSYAFIVFGLMFLLPGYPILCGVFFSCLGIFQSFQNAREANDLVFSALLPVPKQDVARGKLYFSCAVELCTLLLMAIAMATRMTVLADSPVYLKNALMNANPFALGMAFLMFGLFNLIFIAGFFKTSYKFGKPFVTFTVVAFAVIAAAEVLHHVPGLGALNAFGLSHLPLQLGLLAMGVMCYIVLTGIALGRSAARFERTDL
>NZ_CP012069.2|WP_083443732.1|355041_355479_+|helix-turn-helix-domain-containing-protein
MLKDNLLMLRGIHGFSQEEIAERVGISRQAYAKWESGATIPDVEKCARLAREYGTTVDALLRTEEMDDGRVLPPAPKGKNIWGSVCVNERGQIVIPKAARDHFGLRAGQRLILGSDDDEGFVLIPAEIFERKIELMSQILSPAGE
>NZ_CP012069.2|WP_050342900.1|355504_355846_-|hypothetical-protein
MWPYFEPELARRLEGPVVDDSASARACGAPAESLPADGCGVGDAAGRLGVSSRTLRRGIAGEGTTFQRQTGPAREAPTQQRKAMLASGASGRGGSTSSRDGRSAGAGRVAGTL
>NZ_CP012069.2|WP_050342905.1|356358_356751_+|GntR-family-transcriptional-regulator
MLLQLDFSIATPIYQQIRDQIVRGIAEGEFAPDERLPTVRALASECGVNVMTVSKAYQLLKQEGHVRGDRRGGTFVREPNGSSGPNPGTVEALRLRLAELVASGMSGEDVLALCGRLLDDVSSQRDRRLR
>NZ_CP012069.2|WP_050342906.1|356747_358118_+|hypothetical-protein
MSTVSVMWLSCSWIPLLAWWVLRNSARFKKNIVIGVTLPHEARDDGQVVAILTNYRRQQLACTIVLVAVALACAAAGTLRAWAGPLIVCWTLWILAACVVPETVFALANHKLAGLKDERGWRREEMGRGRHVTVADIGAAAQPYTRVSGIWFVLICAVSLVPALLDRNNVVVYLLFAACVLMVWVTFRWCYRDRSEVVDDNTTLTQTLTRIRRRAWARVYLVMAASFALMSWAQLLFRGSADLYLIGMMLPCAVLGIVAFATEMRMRGLQERLTKASGEGLYVDEDDRWIFGIFYYNPDDAKLMVNERVGVNTSINLARPAGKAIMAALALLLLCLPVAGALMADDFGTPVTLELSGQAIHARHSLTSYEIDMDDVVSIELIDQLPQMTRTLGGAAETFLEGDFSSERYGTLKVCLDPEVGPWLLVRTGDGRTYLLGASDATQTKAVLEEAGVDRR

Crispr_ID: NZ_CP012069_6

• CRISPR_ID: NZ_CP012069_6
• CRISPR_location: 385736-385863
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_6

Consensus_repeat	Method
TTCGCCGATCTGTGTACACTCCTGCATACCCACG	CRISPRCasFinder

spacers of NZ_CP012069_6

>6.1|385770|60|NZ_CP012069|CRISPRCasFinder
CCTGCCCGCAGCGGCGCAACAGTGTACACAAATGCCCCGAAACGGCTCCGAGAGTCCGTT

CRISPR arrays and Neighbor proteins around NZ_CP012069_6

CRISPR arrays

The CRISPR arrays of NZ_CP012069_6

>merge|NZ_CP012069|6|385736-385863|CRISPRCasFinder
TTCGCCGATCTGTGTACACTCCTGCATACCCACGCCTGCCCGCAGCGGCGCAACAGTGTACACAAATGCCCCGAAACGGCTCCGAGAGTCCGTTTTCGCCGATCTGTGTACACTCCTGCATACCCACG

>NZ_CP012069|6|4|385736-385863|CRISPRCasFinder
TTCGCCGATCTGTGTACACTCCTGCATACCCACG	CCTGCCCGCAGCGGCGCAACAGTGTACACAAATGCCCCGAAACGGCTCCGAGAGTCCGTT
TTCGCCGATCTGTGTACACTCCTGCATACCCACG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050344683.1|385933_387580_-|SEL1-like-repeat-protein	unknown	unknown	gnl|CDD|223861
NZ_CP012069.2|WP_050342936.1|384247_385513_+|3-isopropylmalate-dehydratase-large-subunit	unknown	unknown	gnl|CDD|234748
NZ_CP012069.2|WP_050342943.1|391753_392551_-|DUF4013-domain-containing-protein	unknown	unknown	gnl|CDD|379068
NZ_CP012069.2|WP_050342924.1|369356_372494_+|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173803
NZ_CP012069.2|WP_083443734.1|382922_384251_+|ATP-binding-protein	unknown	unknown	gnl|CDD|377544
NZ_CP012069.2|WP_050342935.1|381205_382861_+|dihydroxy-acid-dehydratase	unknown	unknown	gnl|CDD|234861
NZ_CP012069.2|WP_050342932.1|376941_377961_+|ketol-acid-reductoisomerase	unknown	unknown	gnl|CDD|235491
NZ_CP012069.2|WP_050344681.1|379921_381121_+|threonine-ammonia-lyase	unknown	unknown	gnl|CDD|236182
NZ_CP012069.2|WP_050342926.1|373054_374590_+|2-isopropylmalate-synthase	unknown	unknown	gnl|CDD|234864
NZ_CP012069.2|WP_050342934.1|378152_379856_+|biosynthetic-type-acetolactate-synthase-large-subunit	unknown	unknown	gnl|CDD|272915
NZ_CP012069.2|WP_050342939.1|389863_390376_+|3-isopropylmalate-dehydratase-small-subunit	unknown	unknown	gnl|CDD|234762
NZ_CP012069.2|WP_050342937.1|388074_388860_+|PD-(D/E)XK-nuclease-family-transposase	unknown	unknown	gnl|CDD|273806
NZ_CP012069.2|WP_157051347.1|389414_389669_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342941.1|390435_391578_+|3-isopropylmalate-dehydrogenase	unknown	unknown	gnl|CDD|234832
NZ_CP012069.2|WP_050342928.1|374661_376353_+|biosynthetic-type-acetolactate-synthase-large-subunit	unknown	unknown	gnl|CDD|223107
NZ_CP012069.2|WP_050342947.1|393430_394192_+|DUF969-domain-containing-protein	unknown	unknown	gnl|CDD|368767
NZ_CP012069.2|WP_050342949.1|394192_395161_+|DUF979-domain-containing-protein	unknown	unknown	gnl|CDD|377620
NZ_CP012069.2|WP_050342952.1|395222_395873_+|pyroglutamyl-peptidase-I	unknown	unknown	gnl|CDD|237299
NZ_CP012069.2|WP_050342930.1|376356_376863_+|acetolactate-synthase-small-subunit	unknown	unknown	gnl|CDD|183365
NZ_CP012069.2|WP_050342945.1|392833_393229_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050344683.1|385933_387580_-|SEL1-like-repeat-protein	gnl|CDD|223861	COG0790, COG0790, FOG: TPR repeat, SEL1 subfamily [General function prediction only].	1.7168e-47
NZ_CP012069.2|WP_050342936.1|384247_385513_+|3-isopropylmalate-dehydratase-large-subunit	gnl|CDD|234748	PRK00402, PRK00402, 3-isopropylmalate dehydratase large subunit; Reviewed.	0
NZ_CP012069.2|WP_050342943.1|391753_392551_-|DUF4013-domain-containing-protein	gnl|CDD|379068	pfam13197, DUF4013, Protein of unknown function (DUF4013). This is a family of uncharacterized proteins that is found in archaea and bacteria.	0.000935365
NZ_CP012069.2|WP_050342924.1|369356_372494_+|S8-family-serine-peptidase	gnl|CDD|173803	cd07477, Peptidases_S8_Subtilisin_subset, Peptidase S8 family domain in Subtilisin proteins. This group is composed of many different subtilisins: Pro-TK-subtilisin, subtilisin Carlsberg, serine protease Pb92 subtilisin, and BPN subtilisins just to name a few. Pro-TK-subtilisin is a serine protease from the hyperthermophilic archaeon Thermococcus kodakaraensis and consists of a signal peptide, a propeptide, and a mature domain. TK-subtilisin is matured from pro-TK-subtilisin upon autoprocessing and degradation of the propeptide. Unlike other subtilisins though, the folding of the unprocessed form of pro-TK-subtilisin is induced by Ca2+ binding which is almost completed prior to autoprocessing. Ca2+ is required for activity unlike the bacterial subtilisins. The propeptide is not required for folding of the mature domain unlike the bacterial subtilases because of the stability produced from Ca2+ binding. Subtilisin Carlsberg is extremely similar in structure to subtilisin BPN'/Novo thought it has a 30% difference in amino acid sequence. The substrate binding regions are also similar and 2 possible Ca2+ binding sites have been identified recently. Subtilisin Carlsberg possesses the highest commercial importance as a proteolytic additive for detergents. Serine protease Pb92, the serine protease from the alkalophilic Bacillus strain PB92, also contains two calcium ions and the overall folding of the polypeptide chain closely resembles that of the subtilisins. Members of the peptidases S8 and S35 clan include endopeptidases, exopeptidases and also a tripeptidyl-peptidase. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The S53 family contains a catalytic triad Glu/Asp/Ser. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	2.46412e-51
NZ_CP012069.2|WP_083443734.1|382922_384251_+|ATP-binding-protein	gnl|CDD|377544	pfam05673, DUF815, Protein of unknown function (DUF815). This family consists of several bacterial proteins of unknown function.	1.9442e-104
NZ_CP012069.2|WP_050342935.1|381205_382861_+|dihydroxy-acid-dehydratase	gnl|CDD|234861	PRK00911, PRK00911, dihydroxy-acid dehydratase; Provisional.	0
NZ_CP012069.2|WP_050342932.1|376941_377961_+|ketol-acid-reductoisomerase	gnl|CDD|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NZ_CP012069.2|WP_050344681.1|379921_381121_+|threonine-ammonia-lyase	gnl|CDD|236182	PRK08198, PRK08198, threonine dehydratase; Provisional.	0
NZ_CP012069.2|WP_050342926.1|373054_374590_+|2-isopropylmalate-synthase	gnl|CDD|234864	PRK00915, PRK00915, 2-isopropylmalate synthase; Validated.	0
NZ_CP012069.2|WP_050342934.1|378152_379856_+|biosynthetic-type-acetolactate-synthase-large-subunit	gnl|CDD|272915	TIGR00118, Probable_acetolactate_synthase_large_subunit, acetolactate synthase, large subunit, biosynthetic type. Two groups of proteins form acetolactate from two molecules of pyruvate. The type of acetolactate synthase described in this model also catalyzes the formation of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, an early step in the branched chain amino acid biosynthesis; it is therefore also termed acetohydroxyacid synthase. In bacteria, this catalytic chain is associated with a smaller regulatory chain in an alpha2/beta2 heterotetramer. Acetolactate synthase is a thiamine pyrophosphate enzyme. In this type, FAD and Mg++ are also found. Several isozymes of this enzyme are found in E. coli K12, one of which contains a frameshift in the large subunit gene and is not expressed. [Amino acid biosynthesis, Pyruvate family].	0
NZ_CP012069.2|WP_050342937.1|388074_388860_+|PD-(D/E)XK-nuclease-family-transposase	gnl|CDD|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	3.56289e-11
NZ_CP012069.2|WP_050342939.1|389863_390376_+|3-isopropylmalate-dehydratase-small-subunit	gnl|CDD|234762	PRK00439, leuD, 3-isopropylmalate dehydratase small subunit; Reviewed.	2.78352e-98
NZ_CP012069.2|WP_050342941.1|390435_391578_+|3-isopropylmalate-dehydrogenase	gnl|CDD|234832	PRK00772, PRK00772, 3-isopropylmalate dehydrogenase; Provisional.	0
NZ_CP012069.2|WP_050342928.1|374661_376353_+|biosynthetic-type-acetolactate-synthase-large-subunit	gnl|CDD|223107	COG0028, IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism].	0
NZ_CP012069.2|WP_050342947.1|393430_394192_+|DUF969-domain-containing-protein	gnl|CDD|368767	pfam06149, DUF969, Protein of unknown function (DUF969). Family of uncharacterized bacterial membrane proteins.	6.44938e-88
NZ_CP012069.2|WP_050342949.1|394192_395161_+|DUF979-domain-containing-protein	gnl|CDD|377620	pfam06166, DUF979, Protein of unknown function (DUF979). This family consists of several putative bacterial membrane proteins. The function of this family is unclear.	3.05508e-122
NZ_CP012069.2|WP_050342930.1|376356_376863_+|acetolactate-synthase-small-subunit	gnl|CDD|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	6.30863e-58
NZ_CP012069.2|WP_050342952.1|395222_395873_+|pyroglutamyl-peptidase-I	gnl|CDD|237299	PRK13197, PRK13197, pyrrolidone-carboxylate peptidase; Provisional.	5.65765e-111

Protein sequences

>NZ_CP012069.2|WP_050342936.1|384247_385513_+|3-isopropylmalate-dehydratase-large-subunit
MTRPMTMAEKILADHAGLDEVVPGQLIECKLDGVLANDITAPIAIKTVRDIGAGVWDKDKIFLVPDHYAPNKDIKSAEQTKVTRDFAHEMGITHYFEQGCMGIEHALLPELGIVVSGDLVIGADSHTCTYGGIGAFSTGVGSTDAGVGMATGRAWFKVPETILFDIEGELPEGACAKDIILFVIGQIGVDGALYCAMEFAGSTISGLSIEGRLTIANMAIEAGGKAGLFEVDDKCRTYVERHAEHPLREYHSDADASYGRVMHIDAADIVPMVSWPHLPSNTHPVTESRHIAIDQSVIGSCTNGRIEDMRLAADVLRGRTVDPKVRCIVIPATQGVWLQCVHEGLMDVFIDAHCVVSTPTCGPCLGGYMGILAAGERCVSSTNRNFVGRMGDPTSEVYLTSPAVAAASAVAGHIALPSDLS
>NZ_CP012069.2|WP_083443734.1|382922_384251_+|ATP-binding-protein
MAGFAQPGSLARSGHSGCLSRQEASELSWRLSALAVFRRLLADPVLADVRACIDAVASEADWEARVACYADTLHRLYESGEASLGSYVRDVTLADENAYLRFLGAGKVIAPSLKAALEAELLTLNAVAALVPQGLLGELPDGVDLASLPRFETTLIDLPAAYAERVAGLWRHGYGIYARYHVFDVDEEGAIAPVRFPDPIRLSDLVDYERERAQIWDNSVALLDGRPAANMLLTGDAGTGKSSTVKAVVNELAPRGLRILEVRKRQLQAIPQILEELTHNPLKFIIFIDDLSFSCEDDNFAALKAILEGSVSAKSDNVVIYATSNRRHLVRESFSEREGDDVHLNDTMQEIVSLSDRFGIHVSFTKPDKATYLDIVRKLASDAQLGMDSAELELQAERFALRRGGRSARGARQFVDGLLSRVPAHAAAQSPISRTRQPKEET
>NZ_CP012069.2|WP_050342935.1|381205_382861_+|dihydroxy-acid-dehydratase
MRSDSIKFGPEAAAHRSLYNALGWTDEEISRPLVGIVSSFNEVVPGHINIDKITDAVKMGIAMAGGMPVVFPAIAVCDGIAMGHTGMRYSLVTRDLIADSTECMALAHGFDALVMIPNCDKNVPGLLMAAARLNLPTTFVSGGPMLAGHIDGHKTSLSSMFEAMGAYTAGKIDEAKLHEFERNVCPSCGSCSGMYTANSMNCLTEVIGMGLPGNGTVPAVYSRRLQLAKHAGMAVMDMLKRGITARDIMCPEAFRNALTVDMALGCSTNTMLHLPAIARECGIELDLAAANAMSERTPNLCHLAPAGPTYMEDLDGAGGVPAVMAELDKAGLINRECMTVTGRTVGENIAGARVSDSSVIRPIDDPFSPTGGIAVLRGNLAPEGSVVKRSAVAPKMLVHEGPARVFESEEDAQSAINAGQIRPGDVVVIRYEGPKGGPGMREMLNPTSAIQGMGLGESVALITDGRFSGATRGACIGHVSPEAASGGVIGVVEEGDLISIDIPACTLELKVPDDELRRRLAAFTPKSKVLSGYLKRYASLVSSGATGAVLN
>NZ_CP012069.2|WP_050344681.1|379921_381121_+|threonine-ammonia-lyase
MLALDRIYHAAYVLKGVARKTDLIAAPHLVSGMEDLYLKTENLQVTGSFKLRGASYKISQLPKGDLERGIIACSAGNHAQGVALAATRMGVRSIVCMPDGAPIMKVESTRRLGAEVRLVKGSYDDAHDEAVRLQEKTGATLIHPYDDEDVICGQGTIGLEIMDQLEGVDAVVVPVGGGGLISGVACAVKSLKPSCQVFGVQAAGASAMAESFCRGDWYASDTASTFADGIAVKNPGEITFQMVRKYVDDIVTVSDDEIAAAILNLMERQKVVAEGAGAVPVAAAMFDKLPLAGKRVVCVVSGGNIDVNILSRVINRGLAMSGRKVTMEIRLTDKPGQLQQVSTIIAELGANVVSVDYDLSDPDLPISSCTLRVGMETRDQAQIDQIRAKLVGEGFALVG
>NZ_CP012069.2|WP_050342934.1|378152_379856_+|biosynthetic-type-acetolactate-synthase-large-subunit
MQLTGAQILIECLKEQGVDVVFGYPGGTILDVYDVLYQTPEIKHYLVSHEQGAAHAADGYARSTGKVGVCLATSGPGCTNLTTGIATAYMDSSPIVAVTCNVSKKLLGKDSFQEVDSTGITRPITKWNRIVSDVHELASAVRQAFLIARSGRPGPVLLDITKDVTGASCDFASLPVKEHRIFELPNQLSRRLMGSLDVHEPDAGSMDSFVALLEKAERPLVICGGGVVRSRATAELNEFANRADAPVAITVMGGGGFRGRDPLTTGMIGMHGSQASNMAVDNCDLLIALGCRFSDRVALQPSTFASQATIVQVDIDSTEMGKNVRCDLSVLGDAKRVLELVNERLPQQSHLVWKEFVFSFPTETQYEGGGDHLTPKQVNSTIARMCPNDTMVATDVGQHQMWAIQHFHYDYPGQLLTSGGFGAMGFGLGAAIGAQVGNPDKRVILVTGDGSFRMNCNELATVEHYGLPIITIVYDNTVLGMVHQWQTLIYDQRYSQTTLDRGPDWVKLADAYGLKGRRVSTEAELEDALGEALGCGRGYVIDAVLDPDEMVRPMVPAGQHITSFLAI
>NZ_CP012069.2|WP_050342932.1|376941_377961_+|ketol-acid-reductoisomerase
MAFRMFYEQDCDVSKLDGKKVAIIGYGSQGHAHALNLKDSGVNVRVALREGSASKAKAESQGLEVVSNAEAAAWADIIMILINDEFQAAMYKKDIEPQLAPGKTLAFAHGFNIHFGCIEVRKDCNVIMVAPKAPGHTVRSEYLAGKGTPCLVCAHQDATGDAFDLALAYGAAIGGARAALLETDFRTETETDLFGEQNVLCGGVTDLMEAGFNTLVEAGYDPRNAYFECIHEMKLIVDLIYESGFTGMRYSISNTAEYGDYTAGPNVITEAAKEGMRHNLRRVQNGEFAKEFLLDMSDESHQVHFKALRRAAAESLMERTGKEIRKMYAWNDEDKLINN
>NZ_CP012069.2|WP_050342930.1|376356_376863_+|acetolactate-synthase-small-subunit
MKTYSIAIMVRNEYGVLNRVTSMFRRRQFNITGLTVSETETEALSRITVQFEGEDRAKSQLVAQLAKLPDVISFKEFDPEDSVSCELLLIKVANEDESRTQVLDAADAFHAKIVDYSRGSIVFRMAGQSRRIDNFIDLMRDFRILEVCRTGVVSLERGGAIMRNVSNI
>NZ_CP012069.2|WP_050342928.1|374661_376353_+|biosynthetic-type-acetolactate-synthase-large-subunit
MEKLNGAQILVRCLINQGVDTIFGYPGGTVIDIYDVLYDVPDKIRHIETTHEQHACHAADGYARATGGCGVVLATSGPGATNLVTGIATAYLDSIPLVAITGNVANSCIGTDAFQELDITGVTLPITKHNYFVRDVSRLQEIVREAFTLAMSGRKGPVLVDIPKDVQTALCDFEELPPVRPPAAAGPSHDSLQAAAKVINQAQRPFVYFGGGVVSSGAGEEVIKLARRINAPMGCSLMGISGIPTDTPGFLGMEGMHGHFASTKAMNACDCLIALGCRFNDRSTGERSKFEPSGKVVRIDLDSSEFSKTIEDRVDVRGDVRLTLEALLPLVEPNTHEEWAREVRELRAQERGYADYRDTLTPKRIMDAINAHREADMPVVTDVGQHQMWAAQYLSFERPRSFVTTGGLGTMGFGLGASIGAALATGKHVVMVTGDGSFAMNMAELITAVDHHIPVTIVLVNNGVLGMVRQMQSLFMRQRYSSTTLDRRVDYVALTKATGAEARRATTPEELDAALAWALATDGPALIECPIDKDEFVTPVLQIGASMDELIVNMDDVQARMGR
>NZ_CP012069.2|WP_050342926.1|373054_374590_+|2-isopropylmalate-synthase
MTRKIDIFDTTLRDGEQSPGASMNTEEKLVIAQELLRMHVDVIEAGFPISSPGDFRSVQEIGRLAGDDAVVVGLTRAVDEDIDRAAEALKTARRPRIHTGLGVSPQHLREKLMIDEDECIERAIHCVSYAKRYVEDVEFYAEDAGRSDQRFLERVIQAAIEAGATVVNIPDTTGYQMPEDFGARIKGLADNVRGIENVTISVHTHNDLGMATALALAGVKNGARQVECTINGLGERAGNTALEEVVMAIRMHGDELDAHTGVVTKELTRASHLVSRITGMQVQANKAIVGSNAFAHSSGIHQDGVLKARDTYEIIDPADVGAAGSEIILSARSGHAALRHRLGELGYSFPDAEFDEVYQRFLEIADQKKEVYDEDLESMVQERQRDIQAIYTLNALQVSCGDPLVPTATATVTDESGTRHVACSTGTGPVDAAYKAIDQIVETHGDLQEFAVKAVTRGIDAIGEVTVRVQAKDGKVYTGRGADNDIIVSSAKAYVNAINRMIQTARSKAGE
>NZ_CP012069.2|WP_050342924.1|369356_372494_+|S8-family-serine-peptidase
MPGNVASTTESPSAGRGRRRAVALAVALLAVSAAVAWGVWGAWRGSDAQGEGAPAGARQGGEVPKASGTPGAAQGPANGTAQAPDPGGEVPQPGAGQAPAGGAEEWPGQSRGFVGPNGEGSHTPDEWPTLEEYNRAWAELGASENELPSVVEGDYVRGVLMICFDRGIGELAAHEIVWARGGVWGYDFFWLRDDGPAYAVCYFPDASDQEALEALAAELRACPGVVSVDLDGMCYLEEDESAELAYLPQQYYLRTSRFIGAWNTVKCNGRATIAVLDSGCDIGHPDLVGNLLPGIDVTKGKDSPPAPSFSDKDGHGTKVAGVASAVAGDFTGIDGASYNAKVLPIRIKDDVGDIKWDYICSALRYIDNHQQQVQVVNMSFSSPNSSVEAQRLVSDLRAKGTVLVAAAGNQYMSGGPLHIYRYPACFDDVISVGSIDASDTIAPDSNHNPRVDLCAPGVGVYTTSSPLATGVQYAMVSGTSFATPQVSAAAALLKVEHPSWGPNLIERALEATARDLGNVGRDDTYGHGALNAEAAVAWLPPADSSVPELWLDRGDVELGPDGAHGYDSSGSELRSASQSVIVRQADGPATAHSIRVVSEGAWDVTLDGVRFDGDRPLLDLSPSASVRVRLRGSSEAIGRSATAATVRVPQGASAVFQSFSEGSLRAESAGRGAVVGGSAQEASGSITFVSGTVEAVARGGGLNMAAAIGGGSDQTNGPIVIDGGTVKASIEEGITITSAIGCCSAGRSKGPAPITIRGGKVEARGNWGSSGIGGHNYGGFGEGSSVEVSGGELTVTGGFQADGIAAESVSFSGDAKVSVTGTRYAAGVAAKELRVSGGSVDVMAGGLLSTGVDADKTQVTGGMLVVRPLDGQTNMGLHGALDVSGGRVSVKAQVPGSSGWPGCAAPAIWGGPVSIRGGTVDAYGGHGAAGIGGGWSGGLADTAGVAVTITGGAVNAVPGEPCKDGIGNGVGATADPIWPTDGTERVWPCAIEHVGDLSTLSVDGRSAADLHIFERNEDGGVHLYLRAGTHTLSCDGATKTVQLGP
>NZ_CP012069.2|WP_050344683.1|385933_387580_-|SEL1-like-repeat-protein
MSVVREGSRAHKKGDYAEALRLFRLAAEQGEADAQSWLGLMYSLGHGVTQSNDEACRWYRLAAEQGEPWAQYRLGTMYKEGYGVTQDDVEACRWYRLAAEQGEPWAQYRLGTMYKKGRGVTQDDVEACRWYRLAAEQGEPWAQYRLGMMYEKGRGVEQDYAEALRLFRLAADQGEAGVRSFVRLMSAGGHGIEQMDAEACRWYRLAAEQGYAWAQYRIAFMYMSGRGVEQDDAEACRWYRLAAEQGEADAQSWLGFMYEKGRGVTQDDVEACRWYWLAAEQGEPWAQYRLGMMYEKGRGVTQDDVEACRWYRLAAEQGYAWAQYRIAFMYMSGRGVEQDDAEACRWYRLAAEQGEADAQSWLGFMYEKGRGVTQDDVEACRWYWLAAEQGEPWAQYRLGMMYEKGRGVTQDDVEACRWYRLAAEQGEPWAQYRLGMMYEKGRGVTQDDVEACRWYRLATEQGEPWAQYRLGMMYEKGCGVEQDYAEALRLFRLAAEQGEAGAQRQLGDMYEFGWGIEKNIPMARHWYELAAGQGDPLAQNALRLMGSE
>NZ_CP012069.2|WP_050342937.1|388074_388860_+|PD-(D/E)XK-nuclease-family-transposase
MKGTQRDVDRLRPIDDPMFRVMALSKAFCEEVLRVLLEDKGLKVVKSTPQAAVTNLRGRSVVLDALCELSDGRLVNVEVQRSEYEDHQRRVRYYASLVTADRTPPGGRFRDVPDVCVVLVGEFDPFGAARSLYHVDRVVRETGRIVENGLCEVYVNALARDGSDVAALMEVFTEAEAYDETRFPATSREKRRLRHTEEGRGTMSRVVEEIRAESKAEGRLEGRAEGRTETLDKLVRDGLVDVRAAAASLGLDPEEVERMLA
>NZ_CP012069.2|WP_157051347.1|389414_389669_+|hypothetical-protein
MSAPRHGSWPDLVEGVFSKMIRQMPCGIRVSSKDEPEERILRHHREADVEPDACRRRWSLSDMGPTVEELVVDTLLSDGAGRAR
>NZ_CP012069.2|WP_050342939.1|389863_390376_+|3-isopropylmalate-dehydratase-small-subunit
MKFEGTAFRYGRDIDTDVIIPARYLNTSDPAELARHCLEDLDTSFVDRVRPGDIIVAEENFGCGSSREHAPVAIKAAGVSVVVAKSFARIFYRNAINIGLPILECPEAVDAVRDGDVISVDADTGAVADKTTGECFSAQPFPPFIQEIINEGGLVNRAKRQVAERRQDKR
>NZ_CP012069.2|WP_050342941.1|390435_391578_+|3-isopropylmalate-dehydrogenase
MAAISYKICTLPGDGIGPEIMDEAKHLLAAIGEAYDVNFNCDDQLIGGCAIDATSAAGAKVSALPPETLEAAREADAVLLAAVGGPRWDDPTPGAVRPEQGLLAIRKNLGLYLNLRPVRVFEALRDASPLRPERLDDVDLLIVRELTGGLYFGTHERRQGVEGAGVGGSVGDVAIDTMEYREYEVERVLRWAYEAAGRRNGVVTSVDKANVLETSRLWREVNHRMNAKFEGVEGEDMLVDNCAMQLVVNPAQFDVLVTENTFGDILSDEASMLTGSLGMLASASLGDGTALYEPSHGSAPDIAGKGIANPIAQILSVELMLRYSFQMDAAADAVAAAVEDVLAAGWRTHDLADEATDAAHRLGTAAMGDKIIEAFRLHAG
>NZ_CP012069.2|WP_050342943.1|391753_392551_-|DUF4013-domain-containing-protein
MQETKYLSHVWAQLTEDKGWITTILMLSVCMLLPVVGWIWIIGYETEWALLIAQGIEGPPERKNIDIVRCFRSGCHTVAATLSWCVILGSFLYLVLRMVSDASFSPNIDALGIINSLFHFWAVFVILSARSSIFMPVLAVVSLYVNFMVIASLRAAICRNPAAGYQAGHILGMIGRDLNGYLNISGMTMIAMFIGNIVFIALSQVAAAMILLSLGISNMVFRIFLFLMFCLPVAIVYTLISLIDYAMVGLWMRQFNEAGSAHPHL
>NZ_CP012069.2|WP_050342945.1|392833_393229_+|hypothetical-protein
MERDANKTGSHKTVTTIVLVVVVLLVVHFGRMLKAYYDGPSVEEALNSPFMRFEREYRNMTYTFLYQGVDEFGQTRYYFRHTDGCTECMILTCKFRWVDHIEGLDFRPAGWDYVYTCYVPEDITTGITTDG
>NZ_CP012069.2|WP_050342947.1|393430_394192_+|DUF969-domain-containing-protein
MEVEVIKLLGIVIVVVGFALKWDSILTIMLAAVVTAIIAGMDPVVFLQTLGKGFVSNRNMLISVVIFLLTGTLERNGLKSAARALMGRIKRASAGLILGAYGVFRVIFAAFNVGFGGVAGFVKPVVMPMAEAADETGGHRMSESHREALKGMAAGMENVAWFFGQVLFVGTSGMLLVQSTMADLGYAVELPRLAAIQIPVAIVAVAVTTVYYLILDKRLMGRDERELAQELAAQGGDEVSGRPSSQASGKEVG
>NZ_CP012069.2|WP_050342949.1|394192_395161_+|DUF979-domain-containing-protein
MNPIQFFQSADVTLSNKLLELVYVIIGLVCVYAGLCNLRDDSNEKRVGTCVFWSVLGLLFIIGPWVPSEVAGALVVVMVLPPIFRQVGAGIDRLKPSEKEMGEGYGELGFRIFIPAFAIGAFSLVFAFLTKISSLVGITVGVFVGMATLVAMRPKKNGARVFLEDSRRMLDIVGPLIMLPTLLAILGATFTAAGVGDVISHIVGAVIPQGNLVVGIVVYCLGMALFTMIMGNAFAAITVMTVGIGAPFVLSLGADPAIVGSLALTCGYCGTLMTPMAANFNIVPVAILEMRDEYGVIKRQIVPALIMLVFQICLMVVLVAVL
>NZ_CP012069.2|WP_050342952.1|395222_395873_+|pyroglutamyl-peptidase-I
MSARMLVTGFQPFGGATMNPAWEAVRRLPDTIGGAEVVKVEIPVVFGRASAAVDAAIEANRPDIVLCVGQAGGRCKITPEFVGINYIDARIPDNEGNQPLAKRVVEDGPDAYFSTLPVRAMAQAMNDAGVPAAVSFTAGTYVCNDVMYALLHSLATRFPGTRGAFLHVPYATEQATQLPADTPSMPIETMAKGLEVALAAALEHMEDVALSVGTTH

Crispr_ID: NZ_CP012069_7

• CRISPR_ID: NZ_CP012069_7
• CRISPR_location: 386217-386803
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of NZ_CP012069_7

Consensus_repeat	Method
TACCAGCGGCAGGCCTCGACGTCGTCCTGCGTGACCCCGCGGCCTTT	PILER-CR

spacers of NZ_CP012069_7

>7.1|386264|61|NZ_CP012069|PILER-CR
CTCGTACATCATGCCCAGCCTGTACTGCGCCCAAGGCTCGCCCTGCTCGGCCGCGAGCCGG
>7.2|386372|61|NZ_CP012069|PILER-CR
CTCGTACATCATGCCCAGCCTGTACTGCGCCCAAGGCTCGCCCTGCTCGGCCGCGAGCCAA
>7.3|386480|61|NZ_CP012069|PILER-CR
CTCATACATGAAGCCGAGCCAGCTTTGCGCATCCGCCTCGCCCTGCTCGGCCGCGAGCCGG
>7.4|386588|78|NZ_CP012069|PILER-CR
TCCACACCACGGCCGCTCATGTACATGAATGCAATCCTGTACTGCGCCCAGGCATAGCCCTGTTCGGCCGCGAGCCGG
>7.5|386713|61|NZ_CP012069|PILER-CR
CTCGTACATCATGCCCAGCCTGTACTGCGCCCAAGGCTCGCCCTGCTCGGCCGCGAGCCAA

CRISPR arrays and Neighbor proteins around NZ_CP012069_7

CRISPR arrays

The CRISPR arrays of NZ_CP012069_7

>merge|NZ_CP012069|7|386217-386803|PILER-CR
TACCAGCGGCAGGCCTCGACGTCGTCCTGCGTGACCCCGCGGCCTTTCTCGTACATCATGCCCAGCCTGTACTGCGCCCAAGGCTCGCCCTGCTCGGCCGCGAGCCGGTACCAGCGGCAGGCCTCGACGTCGTCCTGCGTGACCCCGCGGCCTTTCTCGTACATCATGCCCAGCCTGTACTGCGCCCAAGGCTCGCCCTGCTCGGCCGCGAGCCAATACCAGCGGCAGGCCTCGACGTCGTCCTGCGTGACCCCGCGACCTTTCTCATACATGAAGCCGAGCCAGCTTTGCGCATCCGCCTCGCCCTGCTCGGCCGCGAGCCGGTACCAGCGGCAGGCCTCGGCGTCGTCCTGCTCCACACCACGGCCGCTCATGTACATGAATGCAATCCTGTACTGCGCCCAGGCATAGCCCTGTTCGGCCGCGAGCCGGTACCAGCGGCAGGCCTCGACGTCGTCCTGCGTGACCCCGCGGCCTTTCTCGTACATCATGCCCAGCCTGTACTGCGCCCAAGGCTCGCCCTGCTCGGCCGCGAGCCAATACCAGCGGCAGGCCTCGACGTCGTCCTGCGTGACCCCGCGGCCTTT

>NZ_CP012069|7|2|386217-386803|PILER-CR
TACCAGCGGCAGGCCTCGACGTCGTCCTGCGTGACCCCGCGGCCTTT	CTCGTACATCATGCCCAGCCTGTACTGCGCCCAAGGCTCGCCCTGCTCGGCCGCGAGCCGG
TACCAGCGGCAGGCCTCGACGTCGTCCTGCGTGACCCCGCGGCCTTT	CTCGTACATCATGCCCAGCCTGTACTGCGCCCAAGGCTCGCCCTGCTCGGCCGCGAGCCAA
TACCAGCGGCAGGCCTCGACGTCGTCCTGCGTGACCCCGCGACCTTT	CTCATACATGAAGCCGAGCCAGCTTTGCGCATCCGCCTCGCCCTGCTCGGCCGCGAGCCGG
TACCAGCGGCAGGCCTCGGCGTCGTCCTGCTCCACACCACGGCCGCT	CATGTACATGAATGCAATCCTGTACTGCGCCCAGGCATAGCCCTGTTCGGCCGCGAGCCGGTACCAGCGGCAGGCCTC
GACGTCGTCCTGCGTGACCCCGCGGCCTTTCTCGTACATCATGCCCA	GCCTGTACTGCGCCCAAGGCTCGCCCTGCTCGGCCGCGAGCCAATACCAGCGGCAGGCCTC
GACGTCGTCCTGCGTGACCCCGCGGCCTTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342936.1|384247_385513_+|3-isopropylmalate-dehydratase-large-subunit	unknown	unknown	gnl|CDD|234748
NZ_CP012069.2|WP_050342943.1|391753_392551_-|DUF4013-domain-containing-protein	unknown	unknown	gnl|CDD|379068
NZ_CP012069.2|WP_050342924.1|369356_372494_+|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173803
NZ_CP012069.2|WP_083443734.1|382922_384251_+|ATP-binding-protein	unknown	unknown	gnl|CDD|377544
NZ_CP012069.2|WP_050342935.1|381205_382861_+|dihydroxy-acid-dehydratase	unknown	unknown	gnl|CDD|234861
NZ_CP012069.2|WP_050342932.1|376941_377961_+|ketol-acid-reductoisomerase	unknown	unknown	gnl|CDD|235491
NZ_CP012069.2|WP_050344681.1|379921_381121_+|threonine-ammonia-lyase	unknown	unknown	gnl|CDD|236182
NZ_CP012069.2|WP_050342926.1|373054_374590_+|2-isopropylmalate-synthase	unknown	unknown	gnl|CDD|234864
NZ_CP012069.2|WP_050342937.1|388074_388860_+|PD-(D/E)XK-nuclease-family-transposase	unknown	unknown	gnl|CDD|273806
NZ_CP012069.2|WP_050342939.1|389863_390376_+|3-isopropylmalate-dehydratase-small-subunit	unknown	unknown	gnl|CDD|234762
NZ_CP012069.2|WP_050342934.1|378152_379856_+|biosynthetic-type-acetolactate-synthase-large-subunit	unknown	unknown	gnl|CDD|272915
NZ_CP012069.2|WP_157051347.1|389414_389669_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342954.1|396661_397243_+|DJ-1/PfpI-family-protein	unknown	unknown	gnl|CDD|153229
NZ_CP012069.2|WP_050342941.1|390435_391578_+|3-isopropylmalate-dehydrogenase	unknown	unknown	gnl|CDD|234832
NZ_CP012069.2|WP_050342928.1|374661_376353_+|biosynthetic-type-acetolactate-synthase-large-subunit	unknown	unknown	gnl|CDD|223107
NZ_CP012069.2|WP_050342947.1|393430_394192_+|DUF969-domain-containing-protein	unknown	unknown	gnl|CDD|368767
NZ_CP012069.2|WP_050342949.1|394192_395161_+|DUF979-domain-containing-protein	unknown	unknown	gnl|CDD|377620
NZ_CP012069.2|WP_050342952.1|395222_395873_+|pyroglutamyl-peptidase-I	unknown	unknown	gnl|CDD|237299
NZ_CP012069.2|WP_050342930.1|376356_376863_+|acetolactate-synthase-small-subunit	unknown	unknown	gnl|CDD|183365
NZ_CP012069.2|WP_050342945.1|392833_393229_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342936.1|384247_385513_+|3-isopropylmalate-dehydratase-large-subunit	gnl|CDD|234748	PRK00402, PRK00402, 3-isopropylmalate dehydratase large subunit; Reviewed.	0
NZ_CP012069.2|WP_050342943.1|391753_392551_-|DUF4013-domain-containing-protein	gnl|CDD|379068	pfam13197, DUF4013, Protein of unknown function (DUF4013). This is a family of uncharacterized proteins that is found in archaea and bacteria.	0.000935365
NZ_CP012069.2|WP_050342924.1|369356_372494_+|S8-family-serine-peptidase	gnl|CDD|173803	cd07477, Peptidases_S8_Subtilisin_subset, Peptidase S8 family domain in Subtilisin proteins. This group is composed of many different subtilisins: Pro-TK-subtilisin, subtilisin Carlsberg, serine protease Pb92 subtilisin, and BPN subtilisins just to name a few. Pro-TK-subtilisin is a serine protease from the hyperthermophilic archaeon Thermococcus kodakaraensis and consists of a signal peptide, a propeptide, and a mature domain. TK-subtilisin is matured from pro-TK-subtilisin upon autoprocessing and degradation of the propeptide. Unlike other subtilisins though, the folding of the unprocessed form of pro-TK-subtilisin is induced by Ca2+ binding which is almost completed prior to autoprocessing. Ca2+ is required for activity unlike the bacterial subtilisins. The propeptide is not required for folding of the mature domain unlike the bacterial subtilases because of the stability produced from Ca2+ binding. Subtilisin Carlsberg is extremely similar in structure to subtilisin BPN'/Novo thought it has a 30% difference in amino acid sequence. The substrate binding regions are also similar and 2 possible Ca2+ binding sites have been identified recently. Subtilisin Carlsberg possesses the highest commercial importance as a proteolytic additive for detergents. Serine protease Pb92, the serine protease from the alkalophilic Bacillus strain PB92, also contains two calcium ions and the overall folding of the polypeptide chain closely resembles that of the subtilisins. Members of the peptidases S8 and S35 clan include endopeptidases, exopeptidases and also a tripeptidyl-peptidase. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The S53 family contains a catalytic triad Glu/Asp/Ser. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	2.46412e-51
NZ_CP012069.2|WP_083443734.1|382922_384251_+|ATP-binding-protein	gnl|CDD|377544	pfam05673, DUF815, Protein of unknown function (DUF815). This family consists of several bacterial proteins of unknown function.	1.9442e-104
NZ_CP012069.2|WP_050342935.1|381205_382861_+|dihydroxy-acid-dehydratase	gnl|CDD|234861	PRK00911, PRK00911, dihydroxy-acid dehydratase; Provisional.	0
NZ_CP012069.2|WP_050342932.1|376941_377961_+|ketol-acid-reductoisomerase	gnl|CDD|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NZ_CP012069.2|WP_050344681.1|379921_381121_+|threonine-ammonia-lyase	gnl|CDD|236182	PRK08198, PRK08198, threonine dehydratase; Provisional.	0
NZ_CP012069.2|WP_050342926.1|373054_374590_+|2-isopropylmalate-synthase	gnl|CDD|234864	PRK00915, PRK00915, 2-isopropylmalate synthase; Validated.	0
NZ_CP012069.2|WP_050342937.1|388074_388860_+|PD-(D/E)XK-nuclease-family-transposase	gnl|CDD|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	3.56289e-11
NZ_CP012069.2|WP_050342934.1|378152_379856_+|biosynthetic-type-acetolactate-synthase-large-subunit	gnl|CDD|272915	TIGR00118, Probable_acetolactate_synthase_large_subunit, acetolactate synthase, large subunit, biosynthetic type. Two groups of proteins form acetolactate from two molecules of pyruvate. The type of acetolactate synthase described in this model also catalyzes the formation of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, an early step in the branched chain amino acid biosynthesis; it is therefore also termed acetohydroxyacid synthase. In bacteria, this catalytic chain is associated with a smaller regulatory chain in an alpha2/beta2 heterotetramer. Acetolactate synthase is a thiamine pyrophosphate enzyme. In this type, FAD and Mg++ are also found. Several isozymes of this enzyme are found in E. coli K12, one of which contains a frameshift in the large subunit gene and is not expressed. [Amino acid biosynthesis, Pyruvate family].	0
NZ_CP012069.2|WP_050342939.1|389863_390376_+|3-isopropylmalate-dehydratase-small-subunit	gnl|CDD|234762	PRK00439, leuD, 3-isopropylmalate dehydratase small subunit; Reviewed.	2.78352e-98
NZ_CP012069.2|WP_050342954.1|396661_397243_+|DJ-1/PfpI-family-protein	gnl|CDD|153229	cd03135, GATase1_DJ-1, Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1. Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1. DJ-1 is involved in multiple physiological processes including cancer, Parkinson's disease and male fertility. It is unclear how DJ-1 functions in these. DJ-1 has been shown to possess chaperone activity. DJ-1 is preferentially expressed in the testis and moderately in other tissues; it is induced together with genes involved in oxidative stress response. The Drosophila homologue (DJ-1A) plays an essential role in oxidative stress response and neuronal maintenance. Inhibition of DJ-1A function through RNAi, results in the cellular accumulation of reactive oxygen species, organismal hypersensitivity to oxidative stress, and dysfunction and degeneration of dopaminergic and photoreceptor neurons. DJ-1 has lacks enzymatic activity and the catalytic triad of typical GATase1 domains, however it does contain the highly conserved cysteine located at the nucelophile elbow region typical of these domains. This cysteine been proposed to be a site of regulation of DJ-1 activity by oxidation. DJ-1 is a dimeric enzyme.	4.52881e-60
NZ_CP012069.2|WP_050342941.1|390435_391578_+|3-isopropylmalate-dehydrogenase	gnl|CDD|234832	PRK00772, PRK00772, 3-isopropylmalate dehydrogenase; Provisional.	0
NZ_CP012069.2|WP_050342928.1|374661_376353_+|biosynthetic-type-acetolactate-synthase-large-subunit	gnl|CDD|223107	COG0028, IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism].	0
NZ_CP012069.2|WP_050342947.1|393430_394192_+|DUF969-domain-containing-protein	gnl|CDD|368767	pfam06149, DUF969, Protein of unknown function (DUF969). Family of uncharacterized bacterial membrane proteins.	6.44938e-88
NZ_CP012069.2|WP_050342949.1|394192_395161_+|DUF979-domain-containing-protein	gnl|CDD|377620	pfam06166, DUF979, Protein of unknown function (DUF979). This family consists of several putative bacterial membrane proteins. The function of this family is unclear.	3.05508e-122
NZ_CP012069.2|WP_050342930.1|376356_376863_+|acetolactate-synthase-small-subunit	gnl|CDD|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	6.30863e-58
NZ_CP012069.2|WP_050342952.1|395222_395873_+|pyroglutamyl-peptidase-I	gnl|CDD|237299	PRK13197, PRK13197, pyrrolidone-carboxylate peptidase; Provisional.	5.65765e-111

Protein sequences

>NZ_CP012069.2|WP_050342936.1|384247_385513_+|3-isopropylmalate-dehydratase-large-subunit
MTRPMTMAEKILADHAGLDEVVPGQLIECKLDGVLANDITAPIAIKTVRDIGAGVWDKDKIFLVPDHYAPNKDIKSAEQTKVTRDFAHEMGITHYFEQGCMGIEHALLPELGIVVSGDLVIGADSHTCTYGGIGAFSTGVGSTDAGVGMATGRAWFKVPETILFDIEGELPEGACAKDIILFVIGQIGVDGALYCAMEFAGSTISGLSIEGRLTIANMAIEAGGKAGLFEVDDKCRTYVERHAEHPLREYHSDADASYGRVMHIDAADIVPMVSWPHLPSNTHPVTESRHIAIDQSVIGSCTNGRIEDMRLAADVLRGRTVDPKVRCIVIPATQGVWLQCVHEGLMDVFIDAHCVVSTPTCGPCLGGYMGILAAGERCVSSTNRNFVGRMGDPTSEVYLTSPAVAAASAVAGHIALPSDLS
>NZ_CP012069.2|WP_083443734.1|382922_384251_+|ATP-binding-protein
MAGFAQPGSLARSGHSGCLSRQEASELSWRLSALAVFRRLLADPVLADVRACIDAVASEADWEARVACYADTLHRLYESGEASLGSYVRDVTLADENAYLRFLGAGKVIAPSLKAALEAELLTLNAVAALVPQGLLGELPDGVDLASLPRFETTLIDLPAAYAERVAGLWRHGYGIYARYHVFDVDEEGAIAPVRFPDPIRLSDLVDYERERAQIWDNSVALLDGRPAANMLLTGDAGTGKSSTVKAVVNELAPRGLRILEVRKRQLQAIPQILEELTHNPLKFIIFIDDLSFSCEDDNFAALKAILEGSVSAKSDNVVIYATSNRRHLVRESFSEREGDDVHLNDTMQEIVSLSDRFGIHVSFTKPDKATYLDIVRKLASDAQLGMDSAELELQAERFALRRGGRSARGARQFVDGLLSRVPAHAAAQSPISRTRQPKEET
>NZ_CP012069.2|WP_050342935.1|381205_382861_+|dihydroxy-acid-dehydratase
MRSDSIKFGPEAAAHRSLYNALGWTDEEISRPLVGIVSSFNEVVPGHINIDKITDAVKMGIAMAGGMPVVFPAIAVCDGIAMGHTGMRYSLVTRDLIADSTECMALAHGFDALVMIPNCDKNVPGLLMAAARLNLPTTFVSGGPMLAGHIDGHKTSLSSMFEAMGAYTAGKIDEAKLHEFERNVCPSCGSCSGMYTANSMNCLTEVIGMGLPGNGTVPAVYSRRLQLAKHAGMAVMDMLKRGITARDIMCPEAFRNALTVDMALGCSTNTMLHLPAIARECGIELDLAAANAMSERTPNLCHLAPAGPTYMEDLDGAGGVPAVMAELDKAGLINRECMTVTGRTVGENIAGARVSDSSVIRPIDDPFSPTGGIAVLRGNLAPEGSVVKRSAVAPKMLVHEGPARVFESEEDAQSAINAGQIRPGDVVVIRYEGPKGGPGMREMLNPTSAIQGMGLGESVALITDGRFSGATRGACIGHVSPEAASGGVIGVVEEGDLISIDIPACTLELKVPDDELRRRLAAFTPKSKVLSGYLKRYASLVSSGATGAVLN
>NZ_CP012069.2|WP_050344681.1|379921_381121_+|threonine-ammonia-lyase
MLALDRIYHAAYVLKGVARKTDLIAAPHLVSGMEDLYLKTENLQVTGSFKLRGASYKISQLPKGDLERGIIACSAGNHAQGVALAATRMGVRSIVCMPDGAPIMKVESTRRLGAEVRLVKGSYDDAHDEAVRLQEKTGATLIHPYDDEDVICGQGTIGLEIMDQLEGVDAVVVPVGGGGLISGVACAVKSLKPSCQVFGVQAAGASAMAESFCRGDWYASDTASTFADGIAVKNPGEITFQMVRKYVDDIVTVSDDEIAAAILNLMERQKVVAEGAGAVPVAAAMFDKLPLAGKRVVCVVSGGNIDVNILSRVINRGLAMSGRKVTMEIRLTDKPGQLQQVSTIIAELGANVVSVDYDLSDPDLPISSCTLRVGMETRDQAQIDQIRAKLVGEGFALVG
>NZ_CP012069.2|WP_050342934.1|378152_379856_+|biosynthetic-type-acetolactate-synthase-large-subunit
MQLTGAQILIECLKEQGVDVVFGYPGGTILDVYDVLYQTPEIKHYLVSHEQGAAHAADGYARSTGKVGVCLATSGPGCTNLTTGIATAYMDSSPIVAVTCNVSKKLLGKDSFQEVDSTGITRPITKWNRIVSDVHELASAVRQAFLIARSGRPGPVLLDITKDVTGASCDFASLPVKEHRIFELPNQLSRRLMGSLDVHEPDAGSMDSFVALLEKAERPLVICGGGVVRSRATAELNEFANRADAPVAITVMGGGGFRGRDPLTTGMIGMHGSQASNMAVDNCDLLIALGCRFSDRVALQPSTFASQATIVQVDIDSTEMGKNVRCDLSVLGDAKRVLELVNERLPQQSHLVWKEFVFSFPTETQYEGGGDHLTPKQVNSTIARMCPNDTMVATDVGQHQMWAIQHFHYDYPGQLLTSGGFGAMGFGLGAAIGAQVGNPDKRVILVTGDGSFRMNCNELATVEHYGLPIITIVYDNTVLGMVHQWQTLIYDQRYSQTTLDRGPDWVKLADAYGLKGRRVSTEAELEDALGEALGCGRGYVIDAVLDPDEMVRPMVPAGQHITSFLAI
>NZ_CP012069.2|WP_050342932.1|376941_377961_+|ketol-acid-reductoisomerase
MAFRMFYEQDCDVSKLDGKKVAIIGYGSQGHAHALNLKDSGVNVRVALREGSASKAKAESQGLEVVSNAEAAAWADIIMILINDEFQAAMYKKDIEPQLAPGKTLAFAHGFNIHFGCIEVRKDCNVIMVAPKAPGHTVRSEYLAGKGTPCLVCAHQDATGDAFDLALAYGAAIGGARAALLETDFRTETETDLFGEQNVLCGGVTDLMEAGFNTLVEAGYDPRNAYFECIHEMKLIVDLIYESGFTGMRYSISNTAEYGDYTAGPNVITEAAKEGMRHNLRRVQNGEFAKEFLLDMSDESHQVHFKALRRAAAESLMERTGKEIRKMYAWNDEDKLINN
>NZ_CP012069.2|WP_050342930.1|376356_376863_+|acetolactate-synthase-small-subunit
MKTYSIAIMVRNEYGVLNRVTSMFRRRQFNITGLTVSETETEALSRITVQFEGEDRAKSQLVAQLAKLPDVISFKEFDPEDSVSCELLLIKVANEDESRTQVLDAADAFHAKIVDYSRGSIVFRMAGQSRRIDNFIDLMRDFRILEVCRTGVVSLERGGAIMRNVSNI
>NZ_CP012069.2|WP_050342928.1|374661_376353_+|biosynthetic-type-acetolactate-synthase-large-subunit
MEKLNGAQILVRCLINQGVDTIFGYPGGTVIDIYDVLYDVPDKIRHIETTHEQHACHAADGYARATGGCGVVLATSGPGATNLVTGIATAYLDSIPLVAITGNVANSCIGTDAFQELDITGVTLPITKHNYFVRDVSRLQEIVREAFTLAMSGRKGPVLVDIPKDVQTALCDFEELPPVRPPAAAGPSHDSLQAAAKVINQAQRPFVYFGGGVVSSGAGEEVIKLARRINAPMGCSLMGISGIPTDTPGFLGMEGMHGHFASTKAMNACDCLIALGCRFNDRSTGERSKFEPSGKVVRIDLDSSEFSKTIEDRVDVRGDVRLTLEALLPLVEPNTHEEWAREVRELRAQERGYADYRDTLTPKRIMDAINAHREADMPVVTDVGQHQMWAAQYLSFERPRSFVTTGGLGTMGFGLGASIGAALATGKHVVMVTGDGSFAMNMAELITAVDHHIPVTIVLVNNGVLGMVRQMQSLFMRQRYSSTTLDRRVDYVALTKATGAEARRATTPEELDAALAWALATDGPALIECPIDKDEFVTPVLQIGASMDELIVNMDDVQARMGR
>NZ_CP012069.2|WP_050342926.1|373054_374590_+|2-isopropylmalate-synthase
MTRKIDIFDTTLRDGEQSPGASMNTEEKLVIAQELLRMHVDVIEAGFPISSPGDFRSVQEIGRLAGDDAVVVGLTRAVDEDIDRAAEALKTARRPRIHTGLGVSPQHLREKLMIDEDECIERAIHCVSYAKRYVEDVEFYAEDAGRSDQRFLERVIQAAIEAGATVVNIPDTTGYQMPEDFGARIKGLADNVRGIENVTISVHTHNDLGMATALALAGVKNGARQVECTINGLGERAGNTALEEVVMAIRMHGDELDAHTGVVTKELTRASHLVSRITGMQVQANKAIVGSNAFAHSSGIHQDGVLKARDTYEIIDPADVGAAGSEIILSARSGHAALRHRLGELGYSFPDAEFDEVYQRFLEIADQKKEVYDEDLESMVQERQRDIQAIYTLNALQVSCGDPLVPTATATVTDESGTRHVACSTGTGPVDAAYKAIDQIVETHGDLQEFAVKAVTRGIDAIGEVTVRVQAKDGKVYTGRGADNDIIVSSAKAYVNAINRMIQTARSKAGE
>NZ_CP012069.2|WP_050342924.1|369356_372494_+|S8-family-serine-peptidase
MPGNVASTTESPSAGRGRRRAVALAVALLAVSAAVAWGVWGAWRGSDAQGEGAPAGARQGGEVPKASGTPGAAQGPANGTAQAPDPGGEVPQPGAGQAPAGGAEEWPGQSRGFVGPNGEGSHTPDEWPTLEEYNRAWAELGASENELPSVVEGDYVRGVLMICFDRGIGELAAHEIVWARGGVWGYDFFWLRDDGPAYAVCYFPDASDQEALEALAAELRACPGVVSVDLDGMCYLEEDESAELAYLPQQYYLRTSRFIGAWNTVKCNGRATIAVLDSGCDIGHPDLVGNLLPGIDVTKGKDSPPAPSFSDKDGHGTKVAGVASAVAGDFTGIDGASYNAKVLPIRIKDDVGDIKWDYICSALRYIDNHQQQVQVVNMSFSSPNSSVEAQRLVSDLRAKGTVLVAAAGNQYMSGGPLHIYRYPACFDDVISVGSIDASDTIAPDSNHNPRVDLCAPGVGVYTTSSPLATGVQYAMVSGTSFATPQVSAAAALLKVEHPSWGPNLIERALEATARDLGNVGRDDTYGHGALNAEAAVAWLPPADSSVPELWLDRGDVELGPDGAHGYDSSGSELRSASQSVIVRQADGPATAHSIRVVSEGAWDVTLDGVRFDGDRPLLDLSPSASVRVRLRGSSEAIGRSATAATVRVPQGASAVFQSFSEGSLRAESAGRGAVVGGSAQEASGSITFVSGTVEAVARGGGLNMAAAIGGGSDQTNGPIVIDGGTVKASIEEGITITSAIGCCSAGRSKGPAPITIRGGKVEARGNWGSSGIGGHNYGGFGEGSSVEVSGGELTVTGGFQADGIAAESVSFSGDAKVSVTGTRYAAGVAAKELRVSGGSVDVMAGGLLSTGVDADKTQVTGGMLVVRPLDGQTNMGLHGALDVSGGRVSVKAQVPGSSGWPGCAAPAIWGGPVSIRGGTVDAYGGHGAAGIGGGWSGGLADTAGVAVTITGGAVNAVPGEPCKDGIGNGVGATADPIWPTDGTERVWPCAIEHVGDLSTLSVDGRSAADLHIFERNEDGGVHLYLRAGTHTLSCDGATKTVQLGP
>NZ_CP012069.2|WP_050342937.1|388074_388860_+|PD-(D/E)XK-nuclease-family-transposase
MKGTQRDVDRLRPIDDPMFRVMALSKAFCEEVLRVLLEDKGLKVVKSTPQAAVTNLRGRSVVLDALCELSDGRLVNVEVQRSEYEDHQRRVRYYASLVTADRTPPGGRFRDVPDVCVVLVGEFDPFGAARSLYHVDRVVRETGRIVENGLCEVYVNALARDGSDVAALMEVFTEAEAYDETRFPATSREKRRLRHTEEGRGTMSRVVEEIRAESKAEGRLEGRAEGRTETLDKLVRDGLVDVRAAAASLGLDPEEVERMLA
>NZ_CP012069.2|WP_157051347.1|389414_389669_+|hypothetical-protein
MSAPRHGSWPDLVEGVFSKMIRQMPCGIRVSSKDEPEERILRHHREADVEPDACRRRWSLSDMGPTVEELVVDTLLSDGAGRAR
>NZ_CP012069.2|WP_050342939.1|389863_390376_+|3-isopropylmalate-dehydratase-small-subunit
MKFEGTAFRYGRDIDTDVIIPARYLNTSDPAELARHCLEDLDTSFVDRVRPGDIIVAEENFGCGSSREHAPVAIKAAGVSVVVAKSFARIFYRNAINIGLPILECPEAVDAVRDGDVISVDADTGAVADKTTGECFSAQPFPPFIQEIINEGGLVNRAKRQVAERRQDKR
>NZ_CP012069.2|WP_050342941.1|390435_391578_+|3-isopropylmalate-dehydrogenase
MAAISYKICTLPGDGIGPEIMDEAKHLLAAIGEAYDVNFNCDDQLIGGCAIDATSAAGAKVSALPPETLEAAREADAVLLAAVGGPRWDDPTPGAVRPEQGLLAIRKNLGLYLNLRPVRVFEALRDASPLRPERLDDVDLLIVRELTGGLYFGTHERRQGVEGAGVGGSVGDVAIDTMEYREYEVERVLRWAYEAAGRRNGVVTSVDKANVLETSRLWREVNHRMNAKFEGVEGEDMLVDNCAMQLVVNPAQFDVLVTENTFGDILSDEASMLTGSLGMLASASLGDGTALYEPSHGSAPDIAGKGIANPIAQILSVELMLRYSFQMDAAADAVAAAVEDVLAAGWRTHDLADEATDAAHRLGTAAMGDKIIEAFRLHAG
>NZ_CP012069.2|WP_050342943.1|391753_392551_-|DUF4013-domain-containing-protein
MQETKYLSHVWAQLTEDKGWITTILMLSVCMLLPVVGWIWIIGYETEWALLIAQGIEGPPERKNIDIVRCFRSGCHTVAATLSWCVILGSFLYLVLRMVSDASFSPNIDALGIINSLFHFWAVFVILSARSSIFMPVLAVVSLYVNFMVIASLRAAICRNPAAGYQAGHILGMIGRDLNGYLNISGMTMIAMFIGNIVFIALSQVAAAMILLSLGISNMVFRIFLFLMFCLPVAIVYTLISLIDYAMVGLWMRQFNEAGSAHPHL
>NZ_CP012069.2|WP_050342945.1|392833_393229_+|hypothetical-protein
MERDANKTGSHKTVTTIVLVVVVLLVVHFGRMLKAYYDGPSVEEALNSPFMRFEREYRNMTYTFLYQGVDEFGQTRYYFRHTDGCTECMILTCKFRWVDHIEGLDFRPAGWDYVYTCYVPEDITTGITTDG
>NZ_CP012069.2|WP_050342947.1|393430_394192_+|DUF969-domain-containing-protein
MEVEVIKLLGIVIVVVGFALKWDSILTIMLAAVVTAIIAGMDPVVFLQTLGKGFVSNRNMLISVVIFLLTGTLERNGLKSAARALMGRIKRASAGLILGAYGVFRVIFAAFNVGFGGVAGFVKPVVMPMAEAADETGGHRMSESHREALKGMAAGMENVAWFFGQVLFVGTSGMLLVQSTMADLGYAVELPRLAAIQIPVAIVAVAVTTVYYLILDKRLMGRDERELAQELAAQGGDEVSGRPSSQASGKEVG
>NZ_CP012069.2|WP_050342949.1|394192_395161_+|DUF979-domain-containing-protein
MNPIQFFQSADVTLSNKLLELVYVIIGLVCVYAGLCNLRDDSNEKRVGTCVFWSVLGLLFIIGPWVPSEVAGALVVVMVLPPIFRQVGAGIDRLKPSEKEMGEGYGELGFRIFIPAFAIGAFSLVFAFLTKISSLVGITVGVFVGMATLVAMRPKKNGARVFLEDSRRMLDIVGPLIMLPTLLAILGATFTAAGVGDVISHIVGAVIPQGNLVVGIVVYCLGMALFTMIMGNAFAAITVMTVGIGAPFVLSLGADPAIVGSLALTCGYCGTLMTPMAANFNIVPVAILEMRDEYGVIKRQIVPALIMLVFQICLMVVLVAVL
>NZ_CP012069.2|WP_050342952.1|395222_395873_+|pyroglutamyl-peptidase-I
MSARMLVTGFQPFGGATMNPAWEAVRRLPDTIGGAEVVKVEIPVVFGRASAAVDAAIEANRPDIVLCVGQAGGRCKITPEFVGINYIDARIPDNEGNQPLAKRVVEDGPDAYFSTLPVRAMAQAMNDAGVPAAVSFTAGTYVCNDVMYALLHSLATRFPGTRGAFLHVPYATEQATQLPADTPSMPIETMAKGLEVALAAALEHMEDVALSVGTTH
>NZ_CP012069.2|WP_050342954.1|396661_397243_+|DJ-1/PfpI-family-protein
MFKKTSDKRVAAFFAEGLEECEGLVVCDLLYRAGIRTDKVSISDNLAVTSSHEVTIVCDRTIHDDDFSFDDYDLLFLPGGMPGSNNLRACEMLCNALRSFASAGKDVAAVCAAPYILAELGLLKDRRATSNPGFQHVLTEHGAKLSQDPVVVDGNLITSQGLGTSIELGLTLVGRYLGDEAVESTKGKIVYMR

Crispr_ID: NZ_CP012069_8

• CRISPR_ID: NZ_CP012069_8
• CRISPR_location: 472292-472375
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_8

Consensus_repeat	Method
ACCCCGGCGAAAGTGCCCCGCAG	CRISPRCasFinder

spacers of NZ_CP012069_8

>8.1|472315|38|NZ_CP012069|CRISPRCasFinder
GCTCCGGGGTACCGAGTTTTGGGAATCAACTGGGCAAA

CRISPR arrays and Neighbor proteins around NZ_CP012069_8

CRISPR arrays

The CRISPR arrays of NZ_CP012069_8

>merge|NZ_CP012069|8|472292-472375|CRISPRCasFinder
ACCCCGGCGAAAGTGCCCCGCAGGCTCCGGGGTACCGAGTTTTGGGAATCAACTGGGCAAACCCCGGGCGAAAGTGCCCCGCAG

>NZ_CP012069|8|5|472292-472375|CRISPRCasFinder
ACCCCGGCGAAAGTGCCCCGCAG	GCTCCGGGGTACCGAGTTTTGGGAATCAACTGGGCAAA
CCCCGGGCGAAAGTGCCCCGCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_172674428.1|474969_476454_+|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|225420
NZ_CP012069.2|WP_050343040.1|467287_468832_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl|CDD|235489
NZ_CP012069.2|WP_050343045.1|470152_470620_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343055.1|474462_474948_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|274528
NZ_CP012069.2|WP_050343069.1|487293_488547_-|ATP-binding-protein	unknown	unknown	gnl|CDD|224292
NZ_CP012069.2|WP_050343066.1|483176_486620_+|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl|CDD|224000
NZ_CP012069.2|WP_050343051.1|473354_473675_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl|CDD|367091
NZ_CP012069.2|WP_050343033.1|464366_464882_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343053.1|473661_473919_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	unknown	unknown	gnl|CDD|274102
NZ_CP012069.2|WP_050343064.1|479820_483189_+|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl|CDD|378929
NZ_CP012069.2|WP_050343043.1|469982_470174_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343035.1|464990_465329_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343059.1|477098_477767_-|2'-5'-RNA-ligase-family-protein	unknown	unknown	gnl|CDD|224431
NZ_CP012069.2|WP_050343042.1|469272_469533_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343038.1|465776_467291_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl|CDD|234572
NZ_CP012069.2|WP_050343063.1|479256_479619_-|phage-holin-family-protein	unknown	unknown	gnl|CDD|377198
NZ_CP012069.2|WP_050343047.1|470677_470878_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224393
NZ_CP012069.2|WP_062393066.1|477921_479232_+|DUF2974-domain-containing-protein	unknown	unknown	gnl|CDD|371412
NZ_CP012069.2|WP_050343036.1|465459_465777_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl|CDD|178810
NZ_CP012069.2|WP_157051354.1|471087_472200_-|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl|CDD|377028

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_172674428.1|474969_476454_+|putative-DNA-binding-domain-containing-protein	gnl|CDD|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	2.58337e-31
NZ_CP012069.2|WP_050343040.1|467287_468832_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl|CDD|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP012069.2|WP_050343055.1|474462_474948_+|AAA-family-ATPase	gnl|CDD|274528	TIGR03345, VI_ClpV1, type VI secretion ATPase, ClpV1 family. Members of this protein family are homologs of ClpB, an ATPase associated with chaperone-related functions. These ClpB homologs, designated ClpV1, are a key component of the bacterial pathogenicity-associated type VI secretion system. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	9.18387e-08
NZ_CP012069.2|WP_050343069.1|487293_488547_-|ATP-binding-protein	gnl|CDD|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	7.83726e-57
NZ_CP012069.2|WP_050343066.1|483176_486620_+|UvrD-helicase-domain-containing-protein	gnl|CDD|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	1.97127e-89
NZ_CP012069.2|WP_050343051.1|473354_473675_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl|CDD|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	6.516e-21
NZ_CP012069.2|WP_050343053.1|473661_473919_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	gnl|CDD|274102	TIGR02384, Putative_antitoxin_RelB, addiction module antitoxin, RelB/DinJ family. Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other].	4.99292e-09
NZ_CP012069.2|WP_050343064.1|479820_483189_+|PD-(D/E)XK-nuclease-family-protein	gnl|CDD|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	3.57706e-18
NZ_CP012069.2|WP_050343059.1|477098_477767_-|2'-5'-RNA-ligase-family-protein	gnl|CDD|224431	COG1514, LigT, 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis].	1.96868e-16
NZ_CP012069.2|WP_050343038.1|465776_467291_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl|CDD|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_CP012069.2|WP_050343063.1|479256_479619_-|phage-holin-family-protein	gnl|CDD|377198	pfam04020, Phage_holin_4_2, Mycobacterial 4 TMS phage holin, superfamily IV. These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.	5.05277e-18
NZ_CP012069.2|WP_050343047.1|470677_470878_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	4.40181e-25
NZ_CP012069.2|WP_062393066.1|477921_479232_+|DUF2974-domain-containing-protein	gnl|CDD|371412	pfam11187, DUF2974, Protein of unknown function (DUF2974). This bacterial family of proteins has no known function.	2.9402e-73
NZ_CP012069.2|WP_050343036.1|465459_465777_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl|CDD|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	1.0975e-20
NZ_CP012069.2|WP_157051354.1|471087_472200_-|endonuclease/exonuclease/phosphatase-family-protein	gnl|CDD|377028	pfam03372, Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.	2.20853e-15

Protein sequences

>NZ_CP012069.2|WP_157051354.1|471087_472200_-|endonuclease/exonuclease/phosphatase-family-protein
MTGVKAVRRDAMDRTDKGSTVRRNALSRWWRGRARHGLISLLMWLGMLVVLVLMAARMVPSSRSAGRVIPELVAFVPFAVLPTLVVVLLSILWHRRILAVLSALCLATLVVWHVGYFVPHHTLSDTARSATSTSSGTAPNTDDRVLRLMTLNTLNGRVSASKVVDVVRTQKVELLALQEVSQGFLQELSDAGIHDLLPYSALGSSGRSDNGGINVLFSATQMSDQNTSLLPIETSAMPAGSLSIGGTTVRFVSAHPNSPHKGGQGLWSEGLTTIAKLANYRHSYVILGDFNATWDHARFRELLGSSFVDAGEQAGEGFHMTYPANSTIPPLIEIDHIVYSRDAGLYVGDLQTISVAGSDHLALLATLEAS
>NZ_CP012069.2|WP_050343047.1|470677_470878_-|helix-turn-helix-transcriptional-regulator
MRTRIPELRRERKVSQSELAMAVGVTRQTVTSIETGKYTASLPLAHKIAQYFGLTIEEIFDFSDID
>NZ_CP012069.2|WP_050343045.1|470152_470620_-|hypothetical-protein
METSKTNNANEQLTEELRRFKARLIGQIILGTSLCLIGILGATYGAVTGATQDYTYGLCIGAAAAVLATGIHRLMRARRIDCLREYYAREHDERLAAIRAKSGLPMVLYLMVGMLCATFVALALGQETVADTLIATEIACGAASLLSRAYWSRRI
>NZ_CP012069.2|WP_050343043.1|469982_470174_+|hypothetical-protein
MSDRYRKPAYAGATCGGGAQVMGLTKLIHGREVLSDVFVTVSAGVTVGLFGARPRLAYIRRDQ
>NZ_CP012069.2|WP_050343042.1|469272_469533_+|hypothetical-protein
MTQPLTAMLASLCCAIVLRCSLVLGTCVLVGREDAGGGLALAGGMATGFISSYLSYEVFEATGRIPYSAALLVASELGVLVMAMVA
>NZ_CP012069.2|WP_050343040.1|467287_468832_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MRTLQEVLADWEAVIGLEVHTELTTLDTKMFCNCRLSHDDAPNSNVCPVCLGLPGALPVPNRRAIQSIVMAGLATNCEIQRHSMFYRKHYFYPDMAKNFQTTQGPIAFCMHGHLDLTVSGPGARERPMRESLAADGVTPVSRAADGSYVVPIRILRIHMEEDAAKMVHIGGEEGRIAGASESLIDYNRCGTPLIELVTEPDLRTPEEARLFMEKLRQTFLALGISDCSLESGSMRCDGNVSLRRRGETGLGTKTEMKNINSFKSLHDALEYEIRRQAEVLEEGGVVYQETRHWEPGRRRTVVMRTKETADDYRLFPDPDLAPFDLSDEFIEEARERIPELPDARRERYEASFGLRRDDAAQIAGDPTVAALFEEAVTTAGEKVAPTVANVVINLLPAFGHITAAQAASVSALLAADAISFAQAREVLEAVDGTDADPERVVDERGLRQSTDSAALEPVVDEVLDRCADQVRQYRDGNTKVVGFLVGQCMKASKAAGVKGNPKLFNQLLTARLEA
>NZ_CP012069.2|WP_050343038.1|465776_467291_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MVSLDELSARQIAAGVAAGDFSALEVAKASLSALDAREPQLHAFLQVSAGLALDTARATDERLARGEEPGPLAGVPVAFKDNMHLVGTCTTCASRMLGGYESVFTATCVGRLLAAGATPVGKTNMDEFAFGSSTESSAFHPTNNPWDLTRVPGGSSGGSAAAVAAGEVALALGSDTGGSIRQPASLCGVVGLKPTYGTVSRYGVVAFGSSLDQVGPFARRVEDVALAMNALVAPGPDPLDSTSQDCRADFLGRLDDAVEGRRVGVVPALLEAEGLTGEVKAGIALARRVLEDQGAKVVEVDLPNIASAIAAYYVIAPCEAFSNLARFDGVRYGHQEEGCATLARQTALSRARGFGREAIRRQMLGAYLLSSGTYDRYYYPAQQVRTLITQDYERAYEQCDVILMPATPRTAFRFGEISDPTQMYASDMFTISNNIAGNGGISVPLGLGQESGLPISAQLQGPAFGDATLLSFARAIERGVDAGLGPGKGAPVALGFIGKGGELL
>NZ_CP012069.2|WP_050343036.1|465459_465777_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MPLSKEDVAGIADYARIALSEEELDEMTSYMNEAVALLEPICEYDLDGVEPTFHPIGGLSNVMGNDVVDDSTRALPIDSALLNAASTQGRYFRVPSILGDEEGDR
>NZ_CP012069.2|WP_050343035.1|464990_465329_+|hypothetical-protein
MDSNASRSSEDDTTKSGGGKAKSDDSKASRQRQPFFIGYNEEFDRKLRETAKQYLIESDVLQDTLLKIYRGEFDKLKPNKKSSSAGTQGSEANDKETDVERNNAEETCGEGD
>NZ_CP012069.2|WP_050343033.1|464366_464882_+|hypothetical-protein
MKHKTRDESAAATAPAAGSRSGGGTPTDGGVEEYVEVRGRPTRAFWVVLCVYVVVWVGCLISLGMDASRLDSLGWVLATYLLHVSATFALSVTISVQRRWGPVRWLAILVLAGLFALLPWLVSIIDHVGDSHEVLLPTHEYVVIGLMVSLLGFLAGLILPRRAKLKDIKRP
>NZ_CP012069.2|WP_050343051.1|473354_473675_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MKRGELWTVRGSSYASKPRPVLIVQNDDLDLFDSIVLCLMTSQDSSDISTRVVIDPTEKNGLRKKSWVLTEKIYSARKGELGARIGTLSKEDMVKVSRQLSIVLDL
>NZ_CP012069.2|WP_050343053.1|473661_473919_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin
MATATIPLGNRVDATLKREFDSTAEELGLTPTVALTVFMKRFVTDGGFPFDVRKRPEAFYEPFATEEEALNFTNNAFRRAYDETR
>NZ_CP012069.2|WP_050343055.1|474462_474948_+|AAA-family-ATPase
MRDLLGRESNVVLLDESEKVSYSLYNVFYQLFDEGLFIDTNYEVDIRDGIFILTSNFATGAEIKQSFGAAIYSHIGSCIVFDDLSLEAKQTMAERHVSEVYQCLDDEEKESIDSTDLAAWFQDDAERYDSMRIMKTKIDRVVFGHLTDRLLSDLETEDEPA
>NZ_CP012069.2|WP_172674428.1|474969_476454_+|putative-DNA-binding-domain-containing-protein
MFDLNELKSYREGNRLEVKKALGRDGQGELPRNVWETLSAFANTAGGVIVLGVTERKDGSFVVHGIPKVGKVLDDFWNAALSEDKVSARFMKDSDATLETVEGKDIIVIRVPWVDRHMRPIFINDSIFGGTFRRTHTGDHLCGREEVLSMLRDSDTSSQDAAVAENVQLDHISRETVERYRRRFNERNEGHVWGRVDDTTFLTNIGALRADESSELRPTRAGLLMFGEDRWITYEFPHYFLDYRQEAGAVERWADRFTSQPGDWTGNVYDFYFRVYNKLRAALKVPFRLDGVDRVDDTPAHEALREAIVNALTNANWFDRRGVVCVWDDEAITIANPGDFRMPVEEAKKPGSTDPRNETMMRMFAMVEIGERAGSGMDKIFGGWAWAGYAEPSYEVAYGPDRTTLTLPLASTGDRTRKAVDSSGRFRTEATETARAAILALFPDRRTALKSAEIAERIGLGKTRTNELLRGLVGDGLIVAEGSARNRVYRRAEQ
>NZ_CP012069.2|WP_050343059.1|477098_477767_-|2'-5'-RNA-ligase-family-protein
MGERRLFVALTFSEAERDWLVQRQNALKGHIATGRLTAPGNLHMTLSFIGPCDEDRETLAREALDVAVTAYRNALADKGTGDSPIEGTDGAERPERPALDPSSFPIDLALGHISCFEKRRNSILWVGPTDSGCPQGLGLLQELVADELRVRGLPYGGETFRPHVTLARNVCVPKGVNLAELCATLTSETASVTTRHTSASLMWSDHPKGGSLTYTPIKTVTL
>NZ_CP012069.2|WP_062393066.1|477921_479232_+|DUF2974-domain-containing-protein
MSNMTDYLRWRGDITLEERPLNDVDALVLATVSYLDFDDIVPPDVSGGIALGDACQEVLARTGDDITSAVRSMASIDTSFVVALAQSERFGSLFMSRYLDQVDEATSLQFSAVTIGLPGGDLLISFRGTDSTLVGWREDFMLAFTVTEAQRKAKVYLKDALAGSDAGARVVLAGHSKGGCLAEYAAATCPEALLSRIGRVYSFDGPGLDRAVLLDDAFSRLGERFCHILPRFSVVGQLMDRLEVPRRYIESSEWGIMQHDPMSWQVGPADLVQADGLAPEAKTLDDAIASWLSGEDLETRELFVRELFDILGAGGATTIAEVVTNGGVQRVIAAAAQASEGTKQVIGRLIDTSMQATKESVASGVADGVEGIARVVKRTGENLASRIGESLMVREAATKVAEMGEMLGARALPGQTERSEQEGPADGSGGEEEQDG
>NZ_CP012069.2|WP_050343063.1|479256_479619_-|phage-holin-family-protein
MEFIGRWAVTSIAVMSAVWLVPGIDTVGGDYAGPIMCALALALVNATLKHILVILSFPITIVTLGLFYLVLNALMLELASYLSREIFHAGISIESFGSAFFGAIIVSIVATVVGLVVGAN
>NZ_CP012069.2|WP_050343064.1|479820_483189_+|PD-(D/E)XK-nuclease-family-protein
MSLNILWTDDERLAGADVTRVLTSALSSCAGATLFVPSFAQQQLAACQVARHPDLSLGVTVTTPLAWAEERWGIWGDGRGLVDEAARCLLTREVLSSAPDELRGGLGTNPGTRRLVGELASRALPWMPPAKGGELDDARVCELGLTDGEKAALRLVGRYAQRLHDHGLIERSELLCGVADALREAGVVVAPVVVSGFTSMDRAERELLAGLAGLCEVTVAFGRKNAELLAGCEELAESLRALADRGAQREGPGTRHDGLQGAVPSATAGVRQGGETGLVPSVLADATPADATPSLVRDPELEELLGRLFLASGKRVVARGSVSLLEAAGPHAEAELVARKIDELACKGITSVVVVAPDVERAWRELAPKLEARGVSVTAELPCAFPKTDEGRAFLEFAQGVAQLATLAETWPPSQASAEGELVRLGDMGWWPPRGLADFLLSGISCVPTTQAYRLDRRWRQDRLLTPTDVLRDLQSPKMTSLPVAQATRELLKGRLASAASKLLGPLLGRTEPGLQDFVQDDRGRRTQELARAREALFDARATAVLALVLKVAATLRRLGAVVDPKRGGTVTLAGLVAQATDALSDALVSLRPTLEVAGATCKVRILSARAAAQLEPASVDAVVLMGQSSDESLVGTGDDVLSALLVLLGVERDSDPLPQLRSAFLSTLAAARSRVVLERSLLDRSLRQRWPSVMLTELRSCYEGGGAGKDGLPVERLDEAEADANCAPSGRPSVRVGQEALGQPGAVSPSLRGLVVVPPEGRAELLDGRPLLSASQLESYLECPYKWFSLRRLGLQNSDADLTSLEMGTFAHRVLEVTHRTMLDRARERLLRERGRAANTQLPLTERIEGSRVGEGDSEGLERARRILSDEFDLHLEHQYLRQGKGSRAQVCVPHDDEERGQLEQLRQDLLSTLDYESGLFLGFEPRLFEWSFGRGEAPVEYAGAYLVGTVDRVDVDAHGLAIVIDYKHRSPTVFSKEYGIPTLASLGSFVLPRRVQSLVYGQVVRRRHPDLRVVATVYLSSKGRHAVFGAVSRNVSDRVFGSHPLDPRQLPLTQVDDACDFGVAGSSRGMEALLDATEEAIAEKVEQLLAGHVEADPIDAAACHYCPVMNCDMRRSGWAR
>NZ_CP012069.2|WP_050343066.1|483176_486620_+|UvrD-helicase-domain-containing-protein
MGEVGLAGLSPEQLRIATTLKGALFVEAGAGSGKTFTLTRRVAQALCPGSGEGGAPFLDDLSQVLVITFTNAAAREIRERVRSTLRDAGMREAALQVDSAWISTIHGMCSRILRRHALDLGLDPAFRMATENETSLLQNRALIEVVGAAHASGGRDEDQAVLFDSFGLGRATGASRTGAMRVVDRLCAVAKSATGGFDGLKLAQTADIGQAMGSLLGAYESLHAQRLTPSAAQRVDPALDLVHDFASRAPGQKDASAARELLCQVRSIGFPRPSKAYAEFVFDLRRVFEETWADVVLSESVPALRAALALARTVEKRYGRLKSERSLLDNDDLIGLALAAVRDKAEVAADYAGRFRLVMVDEFQDTDARQLELIGLLAGGGWGRVATVGDAQQSIYRFRGADVGVFREHGRRVPEAGHVRMATNYRSHADVLSFVDAVCGGRKGVLADFMHLEASPGRRDGYRASALDRIDVELVCSDHRSRGVATGVVATCIAERLKAYADAGQSAGDMALLLGTTTHAADYIDAIRACGLECVVTGGSTFTSAPEVGVMAALLHALANPHDTEPGLFPLLASEMFELGADDFVQLGTRPQLVLDAPTKRTVDRGLETMGFYGDEPPSASLRRARDVLWRARQRLRSLPVADVCLEVVRESGWLARLEEEGQEGRSREANVLAAIDYIRDLTDELGLGPARAAGEFDTWLELSKIPPAALAGGGQDSVRVMTIHASKGLEFPICAVAECWSDPRPESGVVSGRDSGGKTRVVLVPPLADKERIDLSRSEPCERPSSVSEVLAQLRSTNALEDAQERTRLLYVGMTRAREALILGIQVIQSKSSGLGPELSAGVVNALFGTELPAPGEHALSFGEGGAGRLRSVRVSTREDYVEIDDGAGPQVQEAQEEPERAPSRTFTLFDVEHSDIEARASLAPVREGIFSYSSVSAQLRASAREALERELDTAWDEAPATNDEDRATNLGSAFHELAQALVESGAYEPGEARLGASVRRWGLSPRAQGRLRAALGRWCGSELRAEARSHSLVRAEIPFFMRVDSTYGEYVEGSIDLLATDAGSRHALVVDYKTGDAGLSEEELRAHHEMQANFYASVLMQGGLKDVECAFCCVERDASELGGRAGQPLVVRYRFDGKHPPRLGS
>NZ_CP012069.2|WP_050343069.1|487293_488547_-|ATP-binding-protein
MEIDRDKYLRDLATRRGNGLVKVVTGARRAGKSYLLFKLYRDLLREESVPDDRIVELAFDLRSSRPLRDPDAFLEWAMPRLEGGGERLVLLDEVQLLGDFEEVLNELSRMPGVDVYVTGSNSKFLSTDIVTEFRGRGDEVHVLPLTFGEFMQCRNDGEARAWADYVEFGGLPLVATMAKPEQKAAYLKNLFEETYIADIIERNGLRKTQELEDLLNVLASSTGSLTNASRVQATFKSVLKSNISLNTVKAYIGYLEDSFLVSAASRYDVKGRKYIGAPLKYYFEDVGLRNARVGFRQGEENHLMENVIYNELRYRGFSVDVGVVKSREYDAEGVQRPVAREVDFVANLAGRRYYVQSAFAIPDAMKAEQEKASLLGIDDSFKKIVVVKDVVNVSRDEHGIVTMGLFDFLLDPNSLER

Crispr_ID: NZ_CP012069_9

• CRISPR_ID: NZ_CP012069_9
• CRISPR_location: 476944-477027
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_9

Consensus_repeat	Method
ACCCCGGCGAAAGTGCCCCGCAG	CRISPRCasFinder

spacers of NZ_CP012069_9

>9.1|476967|38|NZ_CP012069|CRISPRCasFinder
GCTCCGGGGTACCGAGTTTTGGGAATCAACTGGGCAAA

CRISPR arrays and Neighbor proteins around NZ_CP012069_9

CRISPR arrays

The CRISPR arrays of NZ_CP012069_9

>merge|NZ_CP012069|9|476944-477027|CRISPRCasFinder
ACCCCGGCGAAAGTGCCCCGCAGGCTCCGGGGTACCGAGTTTTGGGAATCAACTGGGCAAACCCCGGGCGAAAGTGCCCCGCAG

>NZ_CP012069|9|6|476944-477027|CRISPRCasFinder
ACCCCGGCGAAAGTGCCCCGCAG	GCTCCGGGGTACCGAGTTTTGGGAATCAACTGGGCAAA
CCCCGGGCGAAAGTGCCCCGCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_172674428.1|474969_476454_+|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|225420
NZ_CP012069.2|WP_050343040.1|467287_468832_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl|CDD|235489
NZ_CP012069.2|WP_050343045.1|470152_470620_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343055.1|474462_474948_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|274528
NZ_CP012069.2|WP_050343069.1|487293_488547_-|ATP-binding-protein	unknown	unknown	gnl|CDD|224292
NZ_CP012069.2|WP_050343071.1|488749_489028_+|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	unknown	unknown	gnl|CDD|274102
NZ_CP012069.2|WP_050343066.1|483176_486620_+|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl|CDD|224000
NZ_CP012069.2|WP_050343051.1|473354_473675_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl|CDD|367091
NZ_CP012069.2|WP_050343077.1|490587_491490_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|376540
NZ_CP012069.2|WP_050343053.1|473661_473919_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	unknown	unknown	gnl|CDD|274102
NZ_CP012069.2|WP_050343064.1|479820_483189_+|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl|CDD|378929
NZ_CP012069.2|WP_050343075.1|489442_490192_-|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl|CDD|224268
NZ_CP012069.2|WP_050343043.1|469982_470174_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343059.1|477098_477767_-|2'-5'-RNA-ligase-family-protein	unknown	unknown	gnl|CDD|224431
NZ_CP012069.2|WP_050343042.1|469272_469533_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343063.1|479256_479619_-|phage-holin-family-protein	unknown	unknown	gnl|CDD|377198
NZ_CP012069.2|WP_050343047.1|470677_470878_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224393
NZ_CP012069.2|WP_062393066.1|477921_479232_+|DUF2974-domain-containing-protein	unknown	unknown	gnl|CDD|371412
NZ_CP012069.2|WP_157051354.1|471087_472200_-|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl|CDD|377028
NZ_CP012069.2|WP_050343073.1|489020_489359_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_172674428.1|474969_476454_+|putative-DNA-binding-domain-containing-protein	gnl|CDD|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	2.58337e-31
NZ_CP012069.2|WP_050343040.1|467287_468832_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl|CDD|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP012069.2|WP_050343055.1|474462_474948_+|AAA-family-ATPase	gnl|CDD|274528	TIGR03345, VI_ClpV1, type VI secretion ATPase, ClpV1 family. Members of this protein family are homologs of ClpB, an ATPase associated with chaperone-related functions. These ClpB homologs, designated ClpV1, are a key component of the bacterial pathogenicity-associated type VI secretion system. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	9.18387e-08
NZ_CP012069.2|WP_050343069.1|487293_488547_-|ATP-binding-protein	gnl|CDD|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	7.83726e-57
NZ_CP012069.2|WP_050343071.1|488749_489028_+|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	gnl|CDD|274102	TIGR02384, Putative_antitoxin_RelB, addiction module antitoxin, RelB/DinJ family. Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other].	2.31702e-10
NZ_CP012069.2|WP_050343066.1|483176_486620_+|UvrD-helicase-domain-containing-protein	gnl|CDD|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	1.97127e-89
NZ_CP012069.2|WP_050343051.1|473354_473675_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl|CDD|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	6.516e-21
NZ_CP012069.2|WP_050343077.1|490587_491490_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	2.82924e-14
NZ_CP012069.2|WP_050343053.1|473661_473919_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	gnl|CDD|274102	TIGR02384, Putative_antitoxin_RelB, addiction module antitoxin, RelB/DinJ family. Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other].	4.99292e-09
NZ_CP012069.2|WP_050343064.1|479820_483189_+|PD-(D/E)XK-nuclease-family-protein	gnl|CDD|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	3.57706e-18
NZ_CP012069.2|WP_050343075.1|489442_490192_-|DeoR/GlpR-transcriptional-regulator	gnl|CDD|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.49832e-67
NZ_CP012069.2|WP_050343059.1|477098_477767_-|2'-5'-RNA-ligase-family-protein	gnl|CDD|224431	COG1514, LigT, 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis].	1.96868e-16
NZ_CP012069.2|WP_050343063.1|479256_479619_-|phage-holin-family-protein	gnl|CDD|377198	pfam04020, Phage_holin_4_2, Mycobacterial 4 TMS phage holin, superfamily IV. These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.	5.05277e-18
NZ_CP012069.2|WP_050343047.1|470677_470878_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	4.40181e-25
NZ_CP012069.2|WP_062393066.1|477921_479232_+|DUF2974-domain-containing-protein	gnl|CDD|371412	pfam11187, DUF2974, Protein of unknown function (DUF2974). This bacterial family of proteins has no known function.	2.9402e-73
NZ_CP012069.2|WP_157051354.1|471087_472200_-|endonuclease/exonuclease/phosphatase-family-protein	gnl|CDD|377028	pfam03372, Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.	2.20853e-15

Protein sequences

>NZ_CP012069.2|WP_172674428.1|474969_476454_+|putative-DNA-binding-domain-containing-protein
MFDLNELKSYREGNRLEVKKALGRDGQGELPRNVWETLSAFANTAGGVIVLGVTERKDGSFVVHGIPKVGKVLDDFWNAALSEDKVSARFMKDSDATLETVEGKDIIVIRVPWVDRHMRPIFINDSIFGGTFRRTHTGDHLCGREEVLSMLRDSDTSSQDAAVAENVQLDHISRETVERYRRRFNERNEGHVWGRVDDTTFLTNIGALRADESSELRPTRAGLLMFGEDRWITYEFPHYFLDYRQEAGAVERWADRFTSQPGDWTGNVYDFYFRVYNKLRAALKVPFRLDGVDRVDDTPAHEALREAIVNALTNANWFDRRGVVCVWDDEAITIANPGDFRMPVEEAKKPGSTDPRNETMMRMFAMVEIGERAGSGMDKIFGGWAWAGYAEPSYEVAYGPDRTTLTLPLASTGDRTRKAVDSSGRFRTEATETARAAILALFPDRRTALKSAEIAERIGLGKTRTNELLRGLVGDGLIVAEGSARNRVYRRAEQ
>NZ_CP012069.2|WP_050343055.1|474462_474948_+|AAA-family-ATPase
MRDLLGRESNVVLLDESEKVSYSLYNVFYQLFDEGLFIDTNYEVDIRDGIFILTSNFATGAEIKQSFGAAIYSHIGSCIVFDDLSLEAKQTMAERHVSEVYQCLDDEEKESIDSTDLAAWFQDDAERYDSMRIMKTKIDRVVFGHLTDRLLSDLETEDEPA
>NZ_CP012069.2|WP_050343053.1|473661_473919_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin
MATATIPLGNRVDATLKREFDSTAEELGLTPTVALTVFMKRFVTDGGFPFDVRKRPEAFYEPFATEEEALNFTNNAFRRAYDETR
>NZ_CP012069.2|WP_050343051.1|473354_473675_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MKRGELWTVRGSSYASKPRPVLIVQNDDLDLFDSIVLCLMTSQDSSDISTRVVIDPTEKNGLRKKSWVLTEKIYSARKGELGARIGTLSKEDMVKVSRQLSIVLDL
>NZ_CP012069.2|WP_157051354.1|471087_472200_-|endonuclease/exonuclease/phosphatase-family-protein
MTGVKAVRRDAMDRTDKGSTVRRNALSRWWRGRARHGLISLLMWLGMLVVLVLMAARMVPSSRSAGRVIPELVAFVPFAVLPTLVVVLLSILWHRRILAVLSALCLATLVVWHVGYFVPHHTLSDTARSATSTSSGTAPNTDDRVLRLMTLNTLNGRVSASKVVDVVRTQKVELLALQEVSQGFLQELSDAGIHDLLPYSALGSSGRSDNGGINVLFSATQMSDQNTSLLPIETSAMPAGSLSIGGTTVRFVSAHPNSPHKGGQGLWSEGLTTIAKLANYRHSYVILGDFNATWDHARFRELLGSSFVDAGEQAGEGFHMTYPANSTIPPLIEIDHIVYSRDAGLYVGDLQTISVAGSDHLALLATLEAS
>NZ_CP012069.2|WP_050343047.1|470677_470878_-|helix-turn-helix-transcriptional-regulator
MRTRIPELRRERKVSQSELAMAVGVTRQTVTSIETGKYTASLPLAHKIAQYFGLTIEEIFDFSDID
>NZ_CP012069.2|WP_050343045.1|470152_470620_-|hypothetical-protein
METSKTNNANEQLTEELRRFKARLIGQIILGTSLCLIGILGATYGAVTGATQDYTYGLCIGAAAAVLATGIHRLMRARRIDCLREYYAREHDERLAAIRAKSGLPMVLYLMVGMLCATFVALALGQETVADTLIATEIACGAASLLSRAYWSRRI
>NZ_CP012069.2|WP_050343043.1|469982_470174_+|hypothetical-protein
MSDRYRKPAYAGATCGGGAQVMGLTKLIHGREVLSDVFVTVSAGVTVGLFGARPRLAYIRRDQ
>NZ_CP012069.2|WP_050343042.1|469272_469533_+|hypothetical-protein
MTQPLTAMLASLCCAIVLRCSLVLGTCVLVGREDAGGGLALAGGMATGFISSYLSYEVFEATGRIPYSAALLVASELGVLVMAMVA
>NZ_CP012069.2|WP_050343040.1|467287_468832_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MRTLQEVLADWEAVIGLEVHTELTTLDTKMFCNCRLSHDDAPNSNVCPVCLGLPGALPVPNRRAIQSIVMAGLATNCEIQRHSMFYRKHYFYPDMAKNFQTTQGPIAFCMHGHLDLTVSGPGARERPMRESLAADGVTPVSRAADGSYVVPIRILRIHMEEDAAKMVHIGGEEGRIAGASESLIDYNRCGTPLIELVTEPDLRTPEEARLFMEKLRQTFLALGISDCSLESGSMRCDGNVSLRRRGETGLGTKTEMKNINSFKSLHDALEYEIRRQAEVLEEGGVVYQETRHWEPGRRRTVVMRTKETADDYRLFPDPDLAPFDLSDEFIEEARERIPELPDARRERYEASFGLRRDDAAQIAGDPTVAALFEEAVTTAGEKVAPTVANVVINLLPAFGHITAAQAASVSALLAADAISFAQAREVLEAVDGTDADPERVVDERGLRQSTDSAALEPVVDEVLDRCADQVRQYRDGNTKVVGFLVGQCMKASKAAGVKGNPKLFNQLLTARLEA
>NZ_CP012069.2|WP_050343059.1|477098_477767_-|2'-5'-RNA-ligase-family-protein
MGERRLFVALTFSEAERDWLVQRQNALKGHIATGRLTAPGNLHMTLSFIGPCDEDRETLAREALDVAVTAYRNALADKGTGDSPIEGTDGAERPERPALDPSSFPIDLALGHISCFEKRRNSILWVGPTDSGCPQGLGLLQELVADELRVRGLPYGGETFRPHVTLARNVCVPKGVNLAELCATLTSETASVTTRHTSASLMWSDHPKGGSLTYTPIKTVTL
>NZ_CP012069.2|WP_062393066.1|477921_479232_+|DUF2974-domain-containing-protein
MSNMTDYLRWRGDITLEERPLNDVDALVLATVSYLDFDDIVPPDVSGGIALGDACQEVLARTGDDITSAVRSMASIDTSFVVALAQSERFGSLFMSRYLDQVDEATSLQFSAVTIGLPGGDLLISFRGTDSTLVGWREDFMLAFTVTEAQRKAKVYLKDALAGSDAGARVVLAGHSKGGCLAEYAAATCPEALLSRIGRVYSFDGPGLDRAVLLDDAFSRLGERFCHILPRFSVVGQLMDRLEVPRRYIESSEWGIMQHDPMSWQVGPADLVQADGLAPEAKTLDDAIASWLSGEDLETRELFVRELFDILGAGGATTIAEVVTNGGVQRVIAAAAQASEGTKQVIGRLIDTSMQATKESVASGVADGVEGIARVVKRTGENLASRIGESLMVREAATKVAEMGEMLGARALPGQTERSEQEGPADGSGGEEEQDG
>NZ_CP012069.2|WP_050343063.1|479256_479619_-|phage-holin-family-protein
MEFIGRWAVTSIAVMSAVWLVPGIDTVGGDYAGPIMCALALALVNATLKHILVILSFPITIVTLGLFYLVLNALMLELASYLSREIFHAGISIESFGSAFFGAIIVSIVATVVGLVVGAN
>NZ_CP012069.2|WP_050343064.1|479820_483189_+|PD-(D/E)XK-nuclease-family-protein
MSLNILWTDDERLAGADVTRVLTSALSSCAGATLFVPSFAQQQLAACQVARHPDLSLGVTVTTPLAWAEERWGIWGDGRGLVDEAARCLLTREVLSSAPDELRGGLGTNPGTRRLVGELASRALPWMPPAKGGELDDARVCELGLTDGEKAALRLVGRYAQRLHDHGLIERSELLCGVADALREAGVVVAPVVVSGFTSMDRAERELLAGLAGLCEVTVAFGRKNAELLAGCEELAESLRALADRGAQREGPGTRHDGLQGAVPSATAGVRQGGETGLVPSVLADATPADATPSLVRDPELEELLGRLFLASGKRVVARGSVSLLEAAGPHAEAELVARKIDELACKGITSVVVVAPDVERAWRELAPKLEARGVSVTAELPCAFPKTDEGRAFLEFAQGVAQLATLAETWPPSQASAEGELVRLGDMGWWPPRGLADFLLSGISCVPTTQAYRLDRRWRQDRLLTPTDVLRDLQSPKMTSLPVAQATRELLKGRLASAASKLLGPLLGRTEPGLQDFVQDDRGRRTQELARAREALFDARATAVLALVLKVAATLRRLGAVVDPKRGGTVTLAGLVAQATDALSDALVSLRPTLEVAGATCKVRILSARAAAQLEPASVDAVVLMGQSSDESLVGTGDDVLSALLVLLGVERDSDPLPQLRSAFLSTLAAARSRVVLERSLLDRSLRQRWPSVMLTELRSCYEGGGAGKDGLPVERLDEAEADANCAPSGRPSVRVGQEALGQPGAVSPSLRGLVVVPPEGRAELLDGRPLLSASQLESYLECPYKWFSLRRLGLQNSDADLTSLEMGTFAHRVLEVTHRTMLDRARERLLRERGRAANTQLPLTERIEGSRVGEGDSEGLERARRILSDEFDLHLEHQYLRQGKGSRAQVCVPHDDEERGQLEQLRQDLLSTLDYESGLFLGFEPRLFEWSFGRGEAPVEYAGAYLVGTVDRVDVDAHGLAIVIDYKHRSPTVFSKEYGIPTLASLGSFVLPRRVQSLVYGQVVRRRHPDLRVVATVYLSSKGRHAVFGAVSRNVSDRVFGSHPLDPRQLPLTQVDDACDFGVAGSSRGMEALLDATEEAIAEKVEQLLAGHVEADPIDAAACHYCPVMNCDMRRSGWAR
>NZ_CP012069.2|WP_050343066.1|483176_486620_+|UvrD-helicase-domain-containing-protein
MGEVGLAGLSPEQLRIATTLKGALFVEAGAGSGKTFTLTRRVAQALCPGSGEGGAPFLDDLSQVLVITFTNAAAREIRERVRSTLRDAGMREAALQVDSAWISTIHGMCSRILRRHALDLGLDPAFRMATENETSLLQNRALIEVVGAAHASGGRDEDQAVLFDSFGLGRATGASRTGAMRVVDRLCAVAKSATGGFDGLKLAQTADIGQAMGSLLGAYESLHAQRLTPSAAQRVDPALDLVHDFASRAPGQKDASAARELLCQVRSIGFPRPSKAYAEFVFDLRRVFEETWADVVLSESVPALRAALALARTVEKRYGRLKSERSLLDNDDLIGLALAAVRDKAEVAADYAGRFRLVMVDEFQDTDARQLELIGLLAGGGWGRVATVGDAQQSIYRFRGADVGVFREHGRRVPEAGHVRMATNYRSHADVLSFVDAVCGGRKGVLADFMHLEASPGRRDGYRASALDRIDVELVCSDHRSRGVATGVVATCIAERLKAYADAGQSAGDMALLLGTTTHAADYIDAIRACGLECVVTGGSTFTSAPEVGVMAALLHALANPHDTEPGLFPLLASEMFELGADDFVQLGTRPQLVLDAPTKRTVDRGLETMGFYGDEPPSASLRRARDVLWRARQRLRSLPVADVCLEVVRESGWLARLEEEGQEGRSREANVLAAIDYIRDLTDELGLGPARAAGEFDTWLELSKIPPAALAGGGQDSVRVMTIHASKGLEFPICAVAECWSDPRPESGVVSGRDSGGKTRVVLVPPLADKERIDLSRSEPCERPSSVSEVLAQLRSTNALEDAQERTRLLYVGMTRAREALILGIQVIQSKSSGLGPELSAGVVNALFGTELPAPGEHALSFGEGGAGRLRSVRVSTREDYVEIDDGAGPQVQEAQEEPERAPSRTFTLFDVEHSDIEARASLAPVREGIFSYSSVSAQLRASAREALERELDTAWDEAPATNDEDRATNLGSAFHELAQALVESGAYEPGEARLGASVRRWGLSPRAQGRLRAALGRWCGSELRAEARSHSLVRAEIPFFMRVDSTYGEYVEGSIDLLATDAGSRHALVVDYKTGDAGLSEEELRAHHEMQANFYASVLMQGGLKDVECAFCCVERDASELGGRAGQPLVVRYRFDGKHPPRLGS
>NZ_CP012069.2|WP_050343069.1|487293_488547_-|ATP-binding-protein
MEIDRDKYLRDLATRRGNGLVKVVTGARRAGKSYLLFKLYRDLLREESVPDDRIVELAFDLRSSRPLRDPDAFLEWAMPRLEGGGERLVLLDEVQLLGDFEEVLNELSRMPGVDVYVTGSNSKFLSTDIVTEFRGRGDEVHVLPLTFGEFMQCRNDGEARAWADYVEFGGLPLVATMAKPEQKAAYLKNLFEETYIADIIERNGLRKTQELEDLLNVLASSTGSLTNASRVQATFKSVLKSNISLNTVKAYIGYLEDSFLVSAASRYDVKGRKYIGAPLKYYFEDVGLRNARVGFRQGEENHLMENVIYNELRYRGFSVDVGVVKSREYDAEGVQRPVAREVDFVANLAGRRYYVQSAFAIPDAMKAEQEKASLLGIDDSFKKIVVVKDVVNVSRDEHGIVTMGLFDFLLDPNSLER
>NZ_CP012069.2|WP_050343071.1|488749_489028_+|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin
MATAAVTRRAEIKTRTTDEVKKGATEVYARWGLSLNDAINTFLVKSIEVGGLPFDLRPEVPSYDAIAAVAYRAPLNAEGVAVLPAGWDDGDE
>NZ_CP012069.2|WP_050343073.1|489020_489359_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MSEPIPQPWEVWHARFDFSEGHGYKYRPIIVLATRLDGLLVAMVTGVANKLSLEHDHPIREWEAAGLDKPSIVRLDRIAEIPAGYLGTAGRIGCLTNGDINAIKAILAKITR
>NZ_CP012069.2|WP_050343075.1|489442_490192_-|DeoR/GlpR-transcriptional-regulator
MAKRDSRILSILTSRQRVEVSELSELLGVSEVTVRKDLDALQERGLVIRQHGFATLSNLNDVGGRLAYHYDEKRRIAHEAARLVRDDSTIMVESGSCCALLVRELADTRRGLTIVTNSAFIAGYVRDSANVSCTLLGGTYQRDSQVTVGPLLRTCAREFYVEKLFIGADGWVQGVGPTNADQMRGDAACSMAESAEQVVVLTESEKFGRRGAIPMRLSGKHMSLITDESIPSKWREALTHDGVDVCVAS
>NZ_CP012069.2|WP_050343077.1|490587_491490_+|helix-turn-helix-transcriptional-regulator
MQALSDDSMGIRNNKGAAGQGGCVDSVGDSIQRQRVAHGMSQAALAQSLGISRQSVAKWEAGKSRPELEKMIRLCSLFGCTMDELVYGANRHVEAPAEREVPVPVTVAGGRETPDMPAKDAAGSEASTRADAMRDYDRYVSRRCVLMALGWAVPVMGMGVSSLCVGLGASSSFAVTLWMGSAIAGGMLLRTARLERLEMMGAHPRVDDFHTPEQRRVTRRLQTGVYAAALAMLCSALVLSYASEWVSGYWWHLAGLSWLLLSLAVFLGVRGYQRGGACSTERYNRGSESRASRRSDKKER

Crispr_ID: NZ_CP012069_10

• CRISPR_ID: NZ_CP012069_10
• CRISPR_location: 540222-540307
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_10

Consensus_repeat	Method
GTGCCCCAGAATCTGCGGGGCACT	CRISPRCasFinder

spacers of NZ_CP012069_10

>10.1|540246|38|NZ_CP012069|CRISPRCasFinder
ATCGTAGAGACGTTTTCCCAGTTGGATCCCAAAACTCG

CRISPR arrays and Neighbor proteins around NZ_CP012069_10

CRISPR arrays

The CRISPR arrays of NZ_CP012069_10

>merge|NZ_CP012069|10|540222-540307|CRISPRCasFinder
GTGCCCCAGAATCTGCGGGGCACTATCGTAGAGACGTTTTCCCAGTTGGATCCCAAAACTCGGTACCCCAGAATCTGCGGGGCACT

>NZ_CP012069|10|7|540222-540307|CRISPRCasFinder
GTGCCCCAGAATCTGCGGGGCACT	ATCGTAGAGACGTTTTCCCAGTTGGATCCCAAAACTCG
GTACCCCAGAATCTGCGGGGCACT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_083443746.1|528503_529571_-|site-specific-DNA-methyltransferase	unknown	unknown	gnl|CDD|334588
NZ_CP012069.2|WP_050343145.1|537419_540047_-|hypothetical-protein	unknown	unknown	gnl|CDD|276809
NZ_CP012069.2|WP_050343147.1|540380_541817_-|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl|CDD|213022
NZ_CP012069.2|WP_157051362.1|532014_532317_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343141.1|534903_535608_-|HAD-family-phosphatase	unknown	unknown	gnl|CDD|223710
NZ_CP012069.2|WP_083443749.1|548265_550230_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_050343130.1|530445_531717_+|ISL3-family-transposase	unknown	unknown	gnl|CDD|376574
NZ_CP012069.2|WP_050343128.1|529876_530233_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051364.1|547408_548092_-|peptidylprolyl-isomerase	unknown	unknown	gnl|CDD|223725
NZ_CP012069.2|WP_050343153.1|543872_544253_+|hypothetical-protein	unknown	unknown	gnl|CDD|226447
NZ_CP012069.2|WP_050343149.1|542117_543374_-|DUF1015-domain-containing-protein	unknown	unknown	gnl|CDD|377633
NZ_CP012069.2|WP_050343162.1|552484_553705_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083443748.1|543473_543761_+|HAD-family-hydrolase	unknown	unknown	gnl|CDD|319798
NZ_CP012069.2|WP_157051363.1|533473_533632_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050344697.1|544335_546018_+|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl|CDD|223733
NZ_CP012069.2|WP_050343155.1|546026_547184_-|hypothetical-protein	unknown	unknown	gnl|CDD|223868
NZ_CP012069.2|WP_050343143.1|535774_537187_+|Sapep-family-Mn(2+)-dependent-dipeptidase	unknown	unknown	gnl|CDD|349884
NZ_CP012069.2|WP_083443747.1|532385_533303_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|237171
NZ_CP012069.2|WP_083444076.1|550222_552064_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_050343139.1|534219_534474_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	unknown	unknown	gnl|CDD|274102

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_083443746.1|528503_529571_-|site-specific-DNA-methyltransferase	gnl|CDD|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	6.30088e-08
NZ_CP012069.2|WP_050343155.1|546026_547184_-|hypothetical-protein	gnl|CDD|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	1.42645e-13
NZ_CP012069.2|WP_050343145.1|537419_540047_-|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	8.84367e-08
NZ_CP012069.2|WP_083443748.1|543473_543761_+|HAD-family-hydrolase	gnl|CDD|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	9.31e-13
NZ_CP012069.2|WP_050343141.1|534903_535608_-|HAD-family-phosphatase	gnl|CDD|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	4.74689e-35
NZ_CP012069.2|WP_050343130.1|530445_531717_+|ISL3-family-transposase	gnl|CDD|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	7.9364e-72
NZ_CP012069.2|WP_083443749.1|548265_550230_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	7.1901e-159
NZ_CP012069.2|WP_157051364.1|547408_548092_-|peptidylprolyl-isomerase	gnl|CDD|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	9.57372e-58
NZ_CP012069.2|WP_050343153.1|543872_544253_+|hypothetical-protein	gnl|CDD|226447	COG3937, COG3937, Uncharacterized conserved protein [Function unknown].	3.01696e-08
NZ_CP012069.2|WP_050343149.1|542117_543374_-|DUF1015-domain-containing-protein	gnl|CDD|377633	pfam06245, DUF1015, Protein of unknown function (DUF1015). Family of proteins with unknown function found in archaea and bacteria.	2.72468e-158
NZ_CP012069.2|WP_050344697.1|544335_546018_+|AarF/ABC1/UbiB-kinase-family-protein	gnl|CDD|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	4.81441e-111
NZ_CP012069.2|WP_050343143.1|535774_537187_+|Sapep-family-Mn(2+)-dependent-dipeptidase	gnl|CDD|349884	cd03888, M20_PepV, M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides. Peptidase M20 family, Peptidase V (Xaa-His dipeptidase; PepV g.p. (Lactobacillus lactis); X-His dipeptidase; beta-Ala-His dipeptidase; carnosinase) subfamily. The PepV group of proteins is widely distributed in lactic acid bacteria. PepV, along with PepT, functions at the end of the proteolytic processing system. PepV is a monomeric metalloenzyme that preferentially degrades hydrophobic dipeptides. The Streptococcus gordonii PepV gene is homologous to the PepV gene family from Lactobacillus and Lactococcus spp. PepV recognizes and fixes the dipeptide backbone, while the side chains are not specifically probed and can vary, rendering it a nonspecific dipeptidase. It has been shown that Lactococcus lactis subspecies lactis (L9) PepV does not hydrolyze dipeptides containing Pro or D-amino acids at the C-terminus, while PepV from Lactobaccilus has been shown to have L-carnosine hydrolyzing activity. The mammalian PepV also acts on anserine and homocarnosine (but not on homoanserine), and to a lesser extent on some other aminoacyl-L-histidine dipeptides. Also included is the Staphylococcus aureus metallopeptidase, Sapep, a Mn(2+)-dependent dipeptidase where large interdomain movements could potentially regulate the activity of this enzyme.	3.3756e-128
NZ_CP012069.2|WP_050343147.1|540380_541817_-|polysaccharide-deacetylase-family-protein	gnl|CDD|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	2.69713e-70
NZ_CP012069.2|WP_083443747.1|532385_533303_+|helix-turn-helix-domain-containing-protein	gnl|CDD|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0.000131288
NZ_CP012069.2|WP_083444076.1|550222_552064_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.86836e-157
NZ_CP012069.2|WP_050343139.1|534219_534474_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	gnl|CDD|274102	TIGR02384, Putative_antitoxin_RelB, addiction module antitoxin, RelB/DinJ family. Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other].	4.30349e-09

Protein sequences

>NZ_CP012069.2|WP_050343145.1|537419_540047_-|hypothetical-protein
MLQDTSHHGKASSSSRRLLLAFELLLGVTLLVSCVRVARTGALIWILTVGLEIVVILMLELFRTSAYRDVPIPPREEDVQTAVQSGAAVETKAAAEADDTGTLAEQADSSVVPDEGKAGRVTPHEPIQAPKTLDTHDDHATDEGAMTSKHSQLDLDSLSARITETDDPIAELKLFVGDIRTRMAGGTPDHGKGKRSLSLTVDEAPQHIVHPSGIERFAARVLTEAGLFEDDVELPPLKAVMLNRSSLFYLRIGSKSIPYLARLRVIKLEAALNQIRFATQYLNPRASEQECYELNWLMLNHICVQAGTLDKSLKALEDDIPDSEWSSRRQIATALETLVLPYRLEANFRVNIADGNVSIEFAATPEQVFPSSMPLNGLGIVPSSREVRKRAASVYIQRLAILLAAIAFRSSSKILHVWVAATLDTANRHQCYLSVDFDRWRFSQIDVEKDMDDTGNFNRVYHRFVPAMRIERGILRPVKQTFRLEEPRFCPPRRYEALSLSSRRIPKVQAEVLGCDHVYDLAIEEADKRNYVAIDIMRRLVFDKSDEGSTEKNVRMILDVAGDDPDLSVRSAAERCVQGLIDGTIPEEPFAIGEEFANGDALSKAAERAHEQLDRKDPAGAIMTLKAALADVDGHDLFADSRGIEWRYFGNYVDRALYNRLYGASETSVMLVPDSYFECHLMLSAAYEAQGRHEAACRHAKRTVELAPLDRRAHLHLVHCLEVAGDSEGAIEGLNRLLSTAHDPEGLGIGYYRMAFFQWQKGNILAAEACYKSSLGILRGSFPMAATELATLAMQHPETFREDMSQEEMISILTDADIPIAPTEPIADAFLSCMKASVNAEVFPVARNFVSILAGLYPDDVVFGILRSLETEPDA
>NZ_CP012069.2|WP_050343143.1|535774_537187_+|Sapep-family-Mn(2+)-dependent-dipeptidase
MTDQVLKQQVHDYVESIWEDAVSDIATLVAIRSVEDLDHAEKGKPYGPKPYEALSEAVRIASRLGLDAHNLDGHIGYADVSGASDRQLAMIAHTDIVPEGPGWTFDPFKLTRKDGYLIGRGVLDDKGPLVLSLYAAKWFADRAKGTGEQAPYTVRAIIGSNEETEMADVEWYLERYPQPAFCFSPDADFPLICGEKGGFSATIRSRDISDVIVSLEGGTAGNAVAGEATAIVRADADALPGTDRIEVKPASDGHVRLVAHGIGAHASQPQGSINAIGLLVDYLLDHDLCSAAERDFLDLERLVFGSTDGSTLGIAATDDLFDPLTCIGGTIHTKGGTFEQTIDARYPSSITGEEIARRVGGLAREHGCELSVDLDMVPFSTDPNSAPIQALVATYNEYAGRDAKPYTIGGGTYARHFKVAGAFGPNDPTYPMPDWVGSEHSADEGFSEEQFKRALEIYIVSLSRLMELEL
>NZ_CP012069.2|WP_050343141.1|534903_535608_-|HAD-family-phosphatase
MEGDVAAHNDNDDADRLWPPAFKAAIFDFDGTISDTAALWRQVDEAFLGSRGIECPKDYSRTLSALGFAAGARYTIERFGLSETTQEICDEWNQMGRTLYESNVELRPGAENYICALHRRGIPVALATTNDRDVLDAMRHVDVNSLFDVRVHTGELGLAKDRPEVYLDTAQRLGVRPEECIVFEDLTVAVRSAQATGMATCGIRSNDPTQDVSELRAVSDLWLDDWQDIDVDSS
>NZ_CP012069.2|WP_050343139.1|534219_534474_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin
MATSTFNIQLDSDLKRRVEEVSSGIGLTPTAVFNVFARQFVAHRGFPFAVVTPVPTEREFTEQMDSTYLSMRDGNATEHELIET
>NZ_CP012069.2|WP_157051363.1|533473_533632_+|hypothetical-protein
MARQVLRHIRVRSPGEPGERIEPCPGEADAIPVPRRWRWGIGPSGDGKGDAA
>NZ_CP012069.2|WP_083443747.1|532385_533303_+|helix-turn-helix-domain-containing-protein
MVALQTSLPHDGVMATTRSRGGWHAKDTGGPGARGGRQGGARARGEDQDRAGAAGGQGPHAAAGADGRSLAEIARSLGANADTVALCVRKYREGGAGAALSDAARSGRPASIGDGDRAWVAGLACLGPCELGHPAETRAQSALAAHAGAEAARAGHPALARATKSMVWSIPRAADPRPDRVRHCRERRDPDSGGGGRARCSSPASSSRSASTTTATCCPGRARGRGPASCRVGRREARHPGDRARRPGRGARAGRAGRGAAGGQRAPPARHGVARRRHRPAGRHGGGHRAGAPQEPRVRRAAGGP
>NZ_CP012069.2|WP_157051362.1|532014_532317_-|hypothetical-protein
MQGRVTDAEDELAELEPKRKQAKKEINDAGRKKHEVFEVTYALKNAMGTPDVYDSGQIIANAKKWADDLIAREDENARQKAENDRRARLIADKANKSMSC
>NZ_CP012069.2|WP_050343130.1|530445_531717_+|ISL3-family-transposase
MRRDARMLAALFERSMGLGEAWEVSETWFEEVEGGPDELHVRVARRRGHAVPCPECGVPCGVHDARERTWRHLDIWQSGTYVHCAVPRTDCPEHGAGTVLMPWEVRPNSHFTALFEAQVLAACMRGSTVKAVAEALGEDDRRPRDMLGRAVAQARGSADYSGVRRVGIDETSRSRGHTYISTMLDLDGRRCVAVTDGNDRGSVGRMCDQLEAHGGDRAAITEVTRDMSGSFSSGVSEEMPEATQTIDRFHVMQLFSRATDRVRCRERRESDEKREAPERTKYVWPEREENLTGRQREVRERLAPNRSHLRTARACQMTEAMRDVYGCATAEEARPMLDRLLSWMMHSNVPDMKGVARTVRENREGILGYFGSRLTNAYLEGANSLIQSIKKAARGFRNVEYFTTAIFLRLGGLSFDALACAQS
>NZ_CP012069.2|WP_050343128.1|529876_530233_+|hypothetical-protein
MYDYREAIKEDIRNYIIKNTDWEEHTNRNDLEERLQDMLWTEDSVTGNASGSYTFSRSKAQEYILDNLDLLEEACAGLGTDEATVGRWLLASDFENMDVTIRCYLLSQCIHEVSDEFD
>NZ_CP012069.2|WP_083443746.1|528503_529571_-|site-specific-DNA-methyltransferase
MAKKDTNLKLSHLYKGNVSEVYGRWPSPDLIVSDGAYGVRGFRGDTVDAAGLTDWYKPHVLAWAKAAKPSTSLWFWNTEVGWATVHPLLLSTGWEYVQLAVWDKGLAHIAGNVNGKTIRQLPVVTEVAALYRRTVYLETGDGLTLNAKSWLRAEWRRSGLSLSKSNEACGVKNAATRKYLTADWLWYWPPGDAVQKMAEYCMQYGKKTSWPYFSLDGKTMISAHDWDSLRTTWNHRNGVTNVWSRPPLADSERLKGTMERSAPRTYKPTKQSAAHLNQKPLDLMLTQVAAASNVGDTVWEPFGGLCSASVASSLLGRRSYAAEIDDTFYKLAAARLNEANAYFESNGVYEFKEGE
>NZ_CP012069.2|WP_050343147.1|540380_541817_-|polysaccharide-deacetylase-family-protein
MAAHRNRNDAEKPHAHHLATPDNDTPSDEDDQQAVAGRKAGRPHTRKNVPHVDETPSGAYYIPSATYGQGVNGNVKRKRKSSKVSAVVAIIVVLCIIAGGTYLWINRPVDITLNGEKYTARTGTSLATLITDHKIAVTPGNNVSVSGNVIKEGKGEPFSANVNGRELSGDQLTSYGIARDDDITVGNGADITEDYTATTTEIQPKLKMEGTYGALAYVSQWGKVGKVEKRTGTVSGETCDVTVQEVQDCIITLHMPTPDSGQKIVAITFDDGPSVYTQRYLDILKQHNVKATFFQIGQNVREYPDLAKAVVEAGHQVACHSDTHPDLTTLDEATLQKELSQSISSIKNATGVDTTMLRPPYGSFREATWLKSKGMLSLSVLWTQDSHDWSRPGADKIVSNSLAGIGSGSIILMHDGGGNRDQDLEALPQILETLQNQGYTFVTLSELMQSDSAIPNEIRTGEAKLPANCVWPSELGDA
>NZ_CP012069.2|WP_050343149.1|542117_543374_-|DUF1015-domain-containing-protein
MRTEPISCYRPTPDRVATFASLPYDVFDRDQAATYVRAHPGSFLAIDRPETAFAPHHDMYAPEVYAKAAQILRLRIEDGTLVEDTSPCYYLYRLEQNGHTQTGVVCACSIDEYEDGTIRRHESTTAAKETDRIEHIKATGAQTGPILLAYPDDPTLDRLIRKASETAPLYDFTDDGGVRQTVWRIACATSVEAIRKAFSSIEHAYIADGHHRAASAAKLGLMMRAQKRAGYKRGEALSDLFLAVLFPAGQLRLLAYNRVVSDLAGHTPAELLTAIAAAGFVVGAPSVSAAIPRGRRQFALYLDGSWRDLEFVDGSSLPDDPVSRLDAQILQDRILGPILGIDDPRTSERIRFIGDIEGTGRLEELAGTHGVAFSLFPTSIDELMAVSDAGRLMPPKSTWFEPKLRSGLFIRKIREDAG
>NZ_CP012069.2|WP_083443748.1|543473_543761_+|HAD-family-hydrolase
MPSSETLNRVSRLVTERGQCCVSVAGEVGMGVEDAVMVGDRRYDVEAARTCNVPCVGVELGHTAKSGELECATASVIVSTVDELPDVLLGGAAKN
>NZ_CP012069.2|WP_050343153.1|543872_544253_+|hypothetical-protein
MSGFDDLGDGVRKIFLAGVGAVALGAEKSQEVVSDLVKKGELTVEQGKTVNEELRQKFRDATDDASQAMLTAKLKAMSSEERAAWVSNVQNIASKLDAETVEVEVESDDEAKDGAAKDAEGDGEDK
>NZ_CP012069.2|WP_050344697.1|544335_546018_+|AarF/ABC1/UbiB-kinase-family-protein
MDPDHADTWEETIGLFGGKSSPATRYQITRASKMARLREVLAIASRYDIFHGLTPESFRHLLEELGPTFVKAGQILSMRSEILPQSFCEELAKLRTSVEPMDRDLLLETLRGEYDRPIEEIFDAIDDVPLGSASVAQVHKARLVGGELVAIKVQRPHVQEIMAQDISIMSSLAKRASRLMGDEQFLDLQSVVDELWQSFLEETDFLVEVRSLTEFRHNNADCKFVDCPMPYPKLCTEHVVVMNYVDGIPIGDNDRLVREGYDLEEIGTKLVDNFAQQILDDGFFHADPHPGNLQIQGGRIMYLDFGIVGRLSAHDRGAIQEMAFAVADRDSARLKDGLLSFSTGTTSDIDHPHLLADLDQLVNEFGLTDLSEFDMGAFLNAIIAMARKNGIELPGAMTMLVRSLVTLEGVAYKLLPDISVIEVIQAHIKAHRDPKKLVEDELRQLARGSVKAGRSVVDTLSQASLAMDMLTRGQMRMNLDLPGTTDPMSDIAHAADRLTMGIIVAGLFIGSSVIYYARIQPVIFGIPIIGFIGYLVALALGLWIVYQILREEHRRHKRRP
>NZ_CP012069.2|WP_050343155.1|546026_547184_-|hypothetical-protein
MRQHTIPGIAAKATVAALIAGALTCPPIRALAETPSLEDLQNKAIEAGQNYQIAQDKVDGINKQIEENQSHIDEIEAKLPEQREKAAVAMRMQYRFQESSPNLIGLILDSNSVNEFIEQVTYLDTIANSQADEIAQLNSMEGELTSAKATLEGQKKQAEQDAKEAKRTYDDAQSTSEAAKQKAREDAAAAQAAYEAQVAAGNTSDATTEAVAQSEAKNPSPSPAPVSNPTNKPNKEGNADSGGSPSPSKPSPNNSSNSDDSNPKKSSPKGDSSRGSSDNSSSSDTPSRTTASYTYVLASTYGIGDGLMYSATASGGRVTPTSMGVAMKTMPLGTVIEIIYNGRTARAVVNDRGPYVGNRQIDLQPAVANALGFDGVGRVGYRIVG
>NZ_CP012069.2|WP_157051364.1|547408_548092_-|peptidylprolyl-isomerase
MDRRRLLSWVLATGTLLALDGCTTQSDTTAQDGSGSRQEEDETGSGERSGGTLTSPLDNGYASGYHHATIEVENRGIITLELNATNTPITVSNFADLASRGFYDGLTFHRVIKGFMIQGGDPKGDGTGGSERTIKGEFGSNGVTNAIQHKRGVISMARSAQNDSASSQFFIMQEDQSSLDGNYAAFGKVRDGMDVVDGIANDTPTRDDNGSVAPADQPRIVAIRMVD
>NZ_CP012069.2|WP_083443749.1|548265_550230_-|ABC-transporter-ATP-binding-protein
MSSDDKTKVARSSDEPGETTPDERRGPQDPMGVLGQTIRLVFSYYPVHFVIIVACILADAILTSLPSVFMQQALRIVNEHWQTGDWDAAAQQIMPIVSTLICVYAVAIAAQVVQGQVAAVVTQGTLMKVRNQMFDHMEDLPIRYFDTTKHGDIMSHYTNDVDTLRQLISQALPNLLSMFLQMVATLFIMLWYSLPLAMVVLLIVFLMGWLVRVMGGRSARFFLDQQVKLAGTEGFAEECMNGQKVVKVFTHEREMQAGFDAVNEELFQASKSANIYGNTLGPILMNLGNLAYVLVALAGGTFLTLGVPNLGFGGMALSIDIVVPFLNLTKRFAGSIGQVSQQINFVVMGLAGAERIFALMGEEGEADGGYVTLVRTKRDDNGKLVETDERTDSWAWKHPHRDKGATSYVPLQGEVVLTQVSFGYNPDHVVLHDLSLYALPGQKVAFVGATGAGKTTITNLINRFYDIDDGKIRYDGININKIRKADLRHSLGVVLQDVNLFTGSVMDNIRYGRLDATDEECIAAARLAGADNFIERLPEGYATRLTDNGSQLSQGQRQLISIARAAVADPPVMILDEATSSIDTRTEQIVQRGMDALMKGRTTFVIAHRLSTVRNSDVIIVLDHGRIIERGTHDDLITQKGTYYQLYTGAFELE
>NZ_CP012069.2|WP_083444076.1|550222_552064_-|ABC-transporter-ATP-binding-protein
MATTLGKSIREFKRDSLLAPVLVIGEVVIECIIPFITAQLIDKLQRGAGMDEVGLYSLILIALAIVSLACGAGAGVACSIAATGFARNLRHDIFAAVQRFSFSNIDRFSTSSLVTRLTTDTNNVQLSYMMIIRTAIRAPLMIIFSIVMAFITGGLMAIVYVIVSVALGAAIFGIAIKVMPMFRRIFRKYDRLNDSVEENVSGIRVVKSFARENYEKEKFEEASGSLYHDFVHVERILALILPLMTLSIDVIYTSVIFFGSQAIVTTRGLAMNVGQMSALITYGVSMLMSLMMFSMIFVMVTMSEESARRICEVLLEVPDLKNPRNPRYTVIDGSIDFDHVSFEYSEKAERMALKDIDLHIRSGEVIGIIGGTGSSKSTLIQLISRLYDVTEGTVRVGGYDVRGYDLDTLRNQVSVVLQRNVLFSGTIKENLRWGNADASDEELIEACKLAQADEFIQRMPNGYDTYIEQGGTNVSGGQKQRLCIARALLRRPKVLILDDSTSAVDTKTDKLIRASFKSFIPQTTKIIIAQRTSSVEDADRIVVMDGGKICAIGTHEELLRDSDIYRETYTTQNKQSHDMRMGALDDKETSVTATSEEGPTNAPVTGREDEADE
>NZ_CP012069.2|WP_050343162.1|552484_553705_-|hypothetical-protein
MSKLQGTGKTRLAMALVAVVVILAVGVYLNSMQKPSESRQAKTSDADAANPNTPEKNPAKSADSNIELVASYKADVSGNNAWCAPLQICWDQMRNTTNAGQALEPTADAPAEGRSLADALNAGTFETTKLSDALWYSYAGPMNAEARRQIEEAIAQKFNQKSDILDKLNWQSTNENMLLFYAMLYHTFSFEHPFALSPEKGGFGEDPEANVSYFGTEDAPDDQRRDLLAQVTPLYYSSSDDCACTVKTKEGDLLVLVKKPKGSSFSEMWTNAMAAAQTGDHRPLSNKEDFSCPKLDVDILTTYRALEGLTFDVTDGRKLKIAQAMQTLKMTLDNEGGSVKSEAAITAELTSLDPQGLRTFRFDDSFALFLVDGKATGNVTGDGSLSSDAQPYLALLVNDAKLWQKD

Crispr_ID: NZ_CP012069_11

• CRISPR_ID: NZ_CP012069_11
• CRISPR_location: 600256-600344
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_11

Consensus_repeat	Method
GGCGCACCAACCGGCCGCTACGG	CRISPRCasFinder

spacers of NZ_CP012069_11

>11.1|600279|43|NZ_CP012069|CRISPRCasFinder
AGCACCCGCCAACAACGGCAGCTACGGCGCGCCCGCCAGCAAC

CRISPR arrays and Neighbor proteins around NZ_CP012069_11

CRISPR arrays

The CRISPR arrays of NZ_CP012069_11

>merge|NZ_CP012069|11|600256-600344|CRISPRCasFinder
GGCGCACCAACCGGCCGCTACGGAGCACCCGCCAACAACGGCAGCTACGGCGCGCCCGCCAGCAACGGCGCACCAACCGGCGGCTACGG

>NZ_CP012069|11|8|600256-600344|CRISPRCasFinder
GGCGCACCAACCGGCCGCTACGG	AGCACCCGCCAACAACGGCAGCTACGGCGCGCCCGCCAGCAAC
GGCGCACCAACCGGCGGCTACGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050343230.1|607033_608191_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270262
NZ_CP012069.2|WP_050343210.1|590137_592114_+|molecular-chaperone-HtpG	unknown	unknown	gnl|CDD|235366
NZ_CP012069.2|WP_050343228.1|605353_606472_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343224.1|603415_603853_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|378956
NZ_CP012069.2|WP_083443757.1|597072_597984_+|cysteine-synthase-A	unknown	unknown	gnl|CDD|273463
NZ_CP012069.2|WP_050343233.1|610083_611160_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|226361
NZ_CP012069.2|WP_050343217.1|595317_596394_-|6-phosphofructokinase	unknown	unknown	gnl|CDD|376325
NZ_CP012069.2|WP_050343232.1|608360_610082_+|iron-ABC-transporter-permease	unknown	unknown	gnl|CDD|224099
NZ_CP012069.2|WP_157051574.1|599041_599734_+|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NZ_CP012069.2|WP_050343213.1|592731_593700_-|DNA-polymerase	unknown	unknown	gnl|CDD|176648
NZ_CP012069.2|WP_050343237.1|612360_613692_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|223673
NZ_CP012069.2|WP_050344707.1|613815_614613_+|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl|CDD|377122
NZ_CP012069.2|WP_083444077.1|593971_594889_-|class-II-glutamine-amidotransferase	unknown	unknown	gnl|CDD|238889
NZ_CP012069.2|WP_083443758.1|597993_598638_+|serine-O-acetyltransferase	unknown	unknown	gnl|CDD|223975
NZ_CP012069.2|WP_157051367.1|586750_588901_+|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl|CDD|237057
NZ_CP012069.2|WP_050343212.1|592339_592576_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343222.1|601695_603198_-|L,D-transpeptidase	unknown	unknown	gnl|CDD|341130
NZ_CP012069.2|WP_050343208.1|589036_589759_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl|CDD|224982
NZ_CP012069.2|WP_050343236.1|611200_612253_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|223787
NZ_CP012069.2|WP_050343226.1|603961_604810_+|DegV-family-protein	unknown	unknown	gnl|CDD|273257

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050343230.1|607033_608191_+|ABC-transporter-substrate-binding-protein	gnl|CDD|270262	cd13544, PBP2_Fbp_like_1, Substrate binding domain of a putative ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The substrate domain of this group shows a high homology to the periplasmic component of ferric iron transporter (Fbp), but its biochemical characterization has not been performed. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.70807e-122
NZ_CP012069.2|WP_050343210.1|590137_592114_+|molecular-chaperone-HtpG	gnl|CDD|235366	PRK05218, PRK05218, heat shock protein 90; Provisional.	0
NZ_CP012069.2|WP_050343224.1|603415_603853_+|MarR-family-transcriptional-regulator	gnl|CDD|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	3.91041e-07
NZ_CP012069.2|WP_083443757.1|597072_597984_+|cysteine-synthase-A	gnl|CDD|273463	TIGR01136, Cysteine_synthase, cysteine synthase. This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family].	3.23898e-140
NZ_CP012069.2|WP_050343233.1|610083_611160_+|ABC-transporter-ATP-binding-protein	gnl|CDD|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	2.11389e-152
NZ_CP012069.2|WP_050343217.1|595317_596394_-|6-phosphofructokinase	gnl|CDD|376325	pfam00365, PFK, Phosphofructokinase.	7.24961e-127
NZ_CP012069.2|WP_050343232.1|608360_610082_+|iron-ABC-transporter-permease	gnl|CDD|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	1.19474e-104
NZ_CP012069.2|WP_157051574.1|599041_599734_+|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.15906e-09
NZ_CP012069.2|WP_050343213.1|592731_593700_-|DNA-polymerase	gnl|CDD|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	9.57719e-10
NZ_CP012069.2|WP_050343237.1|612360_613692_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	1.42197e-29
NZ_CP012069.2|WP_050344707.1|613815_614613_+|ADP-ribosylglycohydrolase-family-protein	gnl|CDD|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.71016e-55
NZ_CP012069.2|WP_083444077.1|593971_594889_-|class-II-glutamine-amidotransferase	gnl|CDD|238889	cd01908, YafJ, Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II glutamine amidotransferases including glucosamine-fructose 6-phosphate synthase (GLMS or GFAT), glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase), asparagine synthetase B (AsnB), beta lactam synthetase (beta-LS) and glutamate synthase (GltS). The YafJ fold is also somewhat similar to the Ntn (N-terminal nucleophile) hydrolase fold of the proteasomal alpha and beta subunits.	4.12474e-35
NZ_CP012069.2|WP_083443758.1|597993_598638_+|serine-O-acetyltransferase	gnl|CDD|223975	COG1045, CysE, Serine acetyltransferase [Amino acid transport and metabolism].	1.07898e-76
NZ_CP012069.2|WP_157051367.1|586750_588901_+|zinc-ribbon-domain-containing-protein	gnl|CDD|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	3.02214e-10
NZ_CP012069.2|WP_050343222.1|601695_603198_-|L,D-transpeptidase	gnl|CDD|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	7.64651e-28
NZ_CP012069.2|WP_050343208.1|589036_589759_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl|CDD|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	1.63964e-77
NZ_CP012069.2|WP_050343236.1|611200_612253_+|ABC-transporter-substrate-binding-protein	gnl|CDD|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	2.409e-12
NZ_CP012069.2|WP_050343226.1|603961_604810_+|DegV-family-protein	gnl|CDD|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	6.37592e-78

Protein sequences

>NZ_CP012069.2|WP_157051574.1|599041_599734_+|CPBP-family-intramembrane-metalloprotease
MFALGLLIGFVLNGFCALVALLHGDIRLCFDGVDLLPTVILFVGVLIQSSAEELACRVFMYQRLRDAYARPAVALVGNPALFAVLHLMNNGVTALSVLNIFLVGLLFSMCVYYFNSFWMVAAIHTSWNFTQNILLGLPNSGSVAPFSIFKLDEGAADSLAYNVGFGIEGTALACVVLVAACVCAYVVGQRVGRPAAGGVVGVSACESTDGQVAGELADECGQSSSGDEIG
>NZ_CP012069.2|WP_083443758.1|597993_598638_+|serine-O-acetyltransferase
MPAMMGVVSPPERHPPLWSRAWEDVRAVLRRDPSASSALDVVLFATGLHVVWAYRWQHWLWERGLRRLAILFAQRTRRRYGIDIHPAATIGRRFVIDHGFGLVIGQTSVIGDDCMVYQGVTLGMTGHHGGRRHPTLGDDVMVGAGAIVLGDIHVGSHSKVGAGAVVIHDVPEGVTVAGVPARVIGDRCRGGCCELSLVPPVNTDSEDVRWSCAL
>NZ_CP012069.2|WP_083443757.1|597072_597984_+|cysteine-synthase-A
MRYAHTIEAIIGSTPLIDLSAIAGGKATILGKYEASNPGGSVKDRIVLTMLDAAEADGSLMPGGTVIEPTSGNTGVGLAMLAARRGYKAVLVMPETMSVERRKLAASYGAQIVLTPGGEGMSGAVRRADELRDETPGAIVVGQFVNPANPQAHYEMTGPEIWADTEGDVDVLVAGVGTGGTISGAGRFLKEKRPSVRAIAVEPSESQVLAGKPAGAHRIQGIGAGFVPVTYDASVVDEVVPVTSERAIAMRRRLAEEVGLLVGISSGAAVEVARVLAERLDYADTTIVAVLPDTGERYLSMGL
>NZ_CP012069.2|WP_050343217.1|595317_596394_-|6-phosphofructokinase
MLRIGLLTSGGDCQALNATMRGIVKTIIRQSKGPVEIYGFLDGYHGLIHSKFLQMTWADFSNIHTQGGTILGTSRTPFKLLDTPEADGVNKVAAMKQTYYKLQIDCLFMLGGNGSTKTANRLREEGLNVIALPKTIDNDTWGTDITFGFTSAIDVATTFIDEIKTTASSHGRVFVIEIMGHRVGWIPLHAGVAGGADVILLPEIPYEMKNVIEAIERREAAGGRFAIVAVAEGAISKKEAALPKKEYKKIVAERKYSVAYDIANEIAERTGREVRVGVPGHTQRGGAPDAQDRIFAVQCGVEAARGCLEGTYGFMVAKVNNKMCRVPLKEVAGKLKYVDPKSDLVREAKFMGISFGDE
>NZ_CP012069.2|WP_083444077.1|593971_594889_-|class-II-glutamine-amidotransferase
MCELFAVNSATPVRVNRYLTEFFGHSHANPHGWGVSLRTPAEGMVGDDGVTLWREPLPAYESALAARLLSRPMEARHLQAHIRKATCGTLDVANCHPFLATDVTGRSWTLIHNGILFNEGLLWGYEQREVGQTDSERILLFLIDVIDEAAARQGGRLDFIDTFDVLAGAIVQLGNHNKLNLILDDGAYTYVHTNTSEVTLYAREVTAEEAGIGNTGKVGSDTRDTASASGIIFSTLPLGGENERNAWRPVPRHRLIAYKDGRLRRTSTPHGNVFCEAILDAHRALGDVWDPTAATAAPVTATTAA
>NZ_CP012069.2|WP_050343213.1|592731_593700_-|DNA-polymerase
MNLSQALEHANALVFPGFLSDDETLTAEREKNEEAIGLLMDAWANAPAGKEPFSFDLVRNLADRNRTSCDSYGVERLRDVAPTTLSRKLSGDDLIRGVAALQHRSVEEVIKVAGPSGQDLGVAYVEAPVSGIVCGIDIETTDRDPSRGYIINIGIEFMRLTPAAKPEHPFSSYCGIPELYREKGVPLAFVHHISWDDLAGKKPLRQHNKMQRAILATLEMYPFMAHNASFEDSWFMMQIDGYAEARKAGRITPIDTRDICRRIDPEYKTLPHDSKPATLENWARRRGTLKANQKETHLGLEDVDLMFRTVQAEFAERNMFSS
>NZ_CP012069.2|WP_050343212.1|592339_592576_+|hypothetical-protein
MRKVKTFEGKRRTYDTEKSTEVAKRTIGEFGDSAGYEEILYQTKQGLYFVVGLGGADSPYPSEDIKPLTKSEAADFEA
>NZ_CP012069.2|WP_050343210.1|590137_592114_+|molecular-chaperone-HtpG
MKQFKTESKKLLDLMINSIYTNKEIFLRELISNASDALDKLSFEAIKNPDLGVDQSTLAIRLSFDKEARSVTVSDNGIGMTKAELDENLGTIAHSGSEQFREANADRQGEDIDIIGQFGVGFYSSFMVATKVRVVSRALGADEAFVWESDGVRGYSIEPAGEGERSGAEEHGTDVILFLRESSESDDTDQYLSEGGLRDLVTRYSNYVRHPIQMMVTKSRQKPKPEDAPDDYKPEYEDYQELDTLNSMTPIWKKRQSEVKQEDYNEFYQSTFHDWSDPARTVSFHAEGALSYDALLFIPSRRPFDLYSKDYEKGLALYSSNVLIQEKCADLVPDYYNFVHGVVDSPDVSLNISRETLQQNSQLRAIARRVEKKIHSELEDMRDNDRESYETFFENFGRGIKFGIYNSYGMKAADLADLLLFWSAQEGKQVTFAEYADAMPEGQDKIYFAAGDSRERLEQVPAVRSALDHGFDVLLCTQDVDEFMFQVMRSWHQDGTEGDSEHEGAKERDLELANVANADLDFATDDEKAEAEKATSEHQELFDDLKESLGDKVTSVRVAAGLGDAPATIASEGPVSLEMERVISQGPDADAASAPKAQRVLQLNATHPVFAKLVAAKEAGDKDRLALLGSILYDQALLVEGLPVDDPVEFARNVAKLM
>NZ_CP012069.2|WP_050343208.1|589036_589759_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MKPIIGVTPHYEGNERVLGVRPGYFSVLRACGGLPLMLPLTDDARDIDQLLGLVNGILVTGGVDINPATYGEEPLPQVNPPFDDLDQFEISLIRRAIDRDLPVFGICRGMQAINVALGGTLYQDLPSQYHTGCPHFMEPPLERMSHRVTLLEGGYLKHLLGEETIGVNSRHHQAIRKLADGLARAAVSDDGIIEAIEMPERRFVRAVQWHPELMWRHDDRQQRIIRHFVEACRQGSGGAT
>NZ_CP012069.2|WP_157051367.1|586750_588901_+|zinc-ribbon-domain-containing-protein
MSEYKFCRRCGTQLGPDDNFCTACGAPTDEDFLVAGDGLPVMPVGQVAPEAPLPEAAAPVPGALDVAAASGETVSSDNPTAIWGGADTAAIPEPMAPSVSPAMGWGPSPEQSGVAPDAGTVDTPSGPLPASDVLGPSDVSGGAEAFNTDGIASASAQPFAFVPPYGGGVTGASDAVAQAPVTATSPSDADISSVSADTDDRWFAKVLDVDDAPAAFASASGGDAPADVPVDAPAPPADAPVDATVPPAAFTSASGDDATVPPADAPAIPPAAFAAASGGDAPASPVDAPAPPAAFASASGGDAPASPVDAPVDAPAPPAAFASASGGEAPAVSGGAPIPYLGVSEPDTNAPASSANAPIMPVDLRPTGDSPMPGASTAATVDSAATRRSPKRKVAAGIGVVLLVVLAVLGFFVYKHSREEAARDAIVATTQSMVACDEGLQRLDSVAELNHSYLLPDKTDTAKADKTDTAKRGLDEASSSLTDARRSLESAKSDGWALDDDARHTLDVLQDGLDARRGMIDAGSQLVNSLADVQSAAEELAHLMADSSLFLDSSDNAVNTLNSSSRYIDQIDTTTMINDLESAKKYQASMSDDLRAAREKLPSANLSSYQTTVERASTMVTALQDILDAIQAQDAAKANDAATALNAAIDSFNDARRGLPSLAEGIESLVPDNAKGYAKDYRAQRERVVETLAELGGNPLTRDVVNGSKLLQGSHA
>NZ_CP012069.2|WP_050343222.1|601695_603198_-|L,D-transpeptidase
MTTPKAESHAKGTTTPAHAAKPHETATHAPSDTKATHAKPDEEPNRHIAKRVAIGAATILALLIACYGAGCAYFSSHFVPGTTVDGMDASNLSQDELAAKIDRIAETWSSHITGNGLDLTLAEGDVGLTADGTLRATAARAEVDPKRWPLELLSPKQIETGTGVSLDDTRLQATMQAAIDTVNATAAQPTDAYVTYDEGMGTFVIRDATIGGVIDATSAIDTVKTSALCLRQSLELGEAQLVKPQLTSDSPDLIAARDAANRVLSLEIPLTKGGQELTRVSKDQIARWVSVGEDMQLDVDVDAIDDWASESLSDKVASSDEVHDYDVDSTSVASSIADNLHRCAADTIEIPLAITGERPAESEGARERGRHIDINLSTQYARFYGGDGTVIWRSYLVSGNTSKRHGTPTGEYSILNKATNQTLIGADENHDNKPDYKSHVNYWMPFLGNAYGLHDASWRSRFGGSIYSYAGSHGCINLPREKAAELFDLVNVGDKVNIHW
>NZ_CP012069.2|WP_050343224.1|603415_603853_+|MarR-family-transcriptional-regulator
MSTQFESFVGIISLANKEISRIKGQEMGRMGLKGSDTMCLYYLKKHPEGITSAELARLIGVDRAAVSRILAHLGERGLVRSGGTKGCRGYRVPILLTERGMLAMRESDGVIDSVVNHAIEGVSPEDREAMYRALDAIVDNLEGIE
>NZ_CP012069.2|WP_050343226.1|603961_604810_+|DegV-family-protein
MALKIICDSAADIGQSEMNGVFVAPMSVSFGNVTYQDGVDLTHDRFYEMLVESDSLPTTGQVTPYGFTQVLESALGEGDEAVVMTVSSKLSGTYQSACVAAGEYGDRVRVIDTLNVSLGERILVELANHLVAAGSGLDEVVTTIEGSRGDVQMVALLDTLEYLRKGGRVSGLAGALGAMLSIKPVLACQNGEMILLGKARGSKNGRNLLSEQIEAAGGVDFSLPLAVGYSGMSSALLDKYIRDSRSLWEDHVDELPTVSIGATIGTHAGPNGIAVAFFAKGK
>NZ_CP012069.2|WP_050343228.1|605353_606472_-|hypothetical-protein
MDITFSHTTSLALIRAWRRSHPKQGPPQDQTFHPTCTGRSRPWTSAELKKRMQAIGIQEIPGAWMKRGLTVLCSDKAGRPKTQILRGRVSRPRPKGQYFLELAPATYVCNAALTLTQLTERLSLPQLISLATELEGSYALGPFGIAGEQANFSIKPFVNKDVLLLQLLQLPQSRATRLATRATILSRPNAWSPQEAVLATMIMLSPGEGGYGLGPVTLNPRIQSSGGLPMTRSSRVPDIVFDDTPLALNYDGSDHLNLVGLERATLGLGADPGSSRMAAVVEQLRQQVRKKYVDDRRRDRDLLVAGLEVPVVTNEDISGIDALDLLMAQLIARLERLVGRRFNTQRAALEDPRLTALRARTLQELLARHKSR
>NZ_CP012069.2|WP_050343230.1|607033_608191_+|ABC-transporter-substrate-binding-protein
MRHITRRDFLVATATAATAIGMAGCSGSGGKGGSSGSGSGEDLSRVASQDLIDAAKKDGALVVYGSCEEQHLARCCEHFQELFGIKTDFQRLSTGEVESKVEEEKGNPSADVWFGGTTDPYNVAVTKGILEPYQAKNASHLISDTFRDPDGNWYGIYKGILGFFYNKEDLERKGLEAPKDWPDLVDGKYKGLVWMSNYNTAGTAKLVLNTVIQKYGLDNGIKYLVDLDKNVSVYTKSGSGPSKNVGTGECVIGIGFLHDAVYQIVDNGYGNIGLAIPSSGASYEVGATAIFKGAKHQDAAKLWVEYALSPQCVDEAQKVGAYQFLVIDDAKQPEVVNEYGLDPNNVMDYNFADAKEHTEEYVKDIMEALAKSGSNTGDTSRFQTE
>NZ_CP012069.2|WP_050343232.1|608360_610082_+|iron-ABC-transporter-permease
MAKSQGARLDRSKLLADPILVATIVVLIAFLTLFILYPLAILMVDSVVGEHGPTLDVFARVLAMPTFDTAITNTLSLGLFVGVAAALIGLLFAYVEEYVQLKSRLMSGLFKLVSLLPVVSPPFVLSLSVIMLFGKAGIITRHMLGIYDNNVYGFWGIALVQTMTFFPVCYMMFKGLLKNIDPSLEEAARDMGASRWKVFTSVTLPLVLPGIGNAFLVTFIESIADFANPMLIGGSFDTLATSIYLQITGAYDKQGAAAMAVVLLLITLAMFVVQKYVLEARATATLTGKASRARMLITDNSVRIPLSVLCAAVALFVVLMYICVPFGALFKTWGYDFTLTTKWFQQMFTMHHGFQAFRDSFLLSLIAAPITALLSMVISYLVVKRRFRSRGFIEAVSMLAMAVPGTVLGVGYIRGFSGGIFHTGVLQGLYGTAAILIIVFIVRSLPTGTRSGISALRQIDKSIEESAYDMGANSLQVFMTVTLPLIKDSFLSGLVTSFVRSITAISAIILLVTPQFLLITVQINEFAEKGAYGVACAFATVLICITYGAVALMNLAIRRFGTSARLESANEEA
>NZ_CP012069.2|WP_050343233.1|610083_611160_+|ABC-transporter-ATP-binding-protein
MSKEKKGVRLEHISKIYQDPKTGKDFYAVRDATIDIGPGEFVTLLGPSGCGKTTILRMVAGFESPDEGEVYLGGEAINTLTPNKRDTAMVFQSYALLPHYNIFDNVAYGLRLRKMDKATIEQKVSHILELVGLEGMERRMTNQLSGGQQQRVALARALVIEPGVLLFDEPLSNLDAKLRVDMRSEIRRIQQEAGITAIYVTHDQSEAMALSDRIIVMKRGLVDQIGSPKEVYYHPQDEFVADFIGESNFLHGTLQSVSGNSGVALIEGQSVPVEGVNGRATGDEVTLVLRPESAHVGEVGVMPCEVTLSRFMGHYQDYQLRCGKHLVKVTEFNPKNRRSYEVGEQAFLSFAPDDVHVL
>NZ_CP012069.2|WP_050343236.1|611200_612253_+|ABC-transporter-substrate-binding-protein
MTARNARFLTRREAVGASLGLALSLGLAACSGQQGTPQSSGGSADQSGSDGKDKATTIKVASLKGPTSIGIASLMDKANKGETQNHYDFKVASSPDEVIPEVAKGGFDIALVPSNSAAVLYNKTDAGVSVIDINTLGVLFVVTANADIREFADLSGHTVYLSGKGASPEYTMRKLLDKAGIASSVTLEYKSEHAEVVSMLMGDESAIGILPQPFVTVATTKNAKLKASIDLTELWGRLNDDGSKLVQGVTIVQRSFLNEHPDAVQSFIREHADSVQAANTDPKAVAPLVVSAGILDSEEVVERAIPGCHLVCITGDEMKAALHGYLQVLFDADAASVGGVLPADDFYHIG
>NZ_CP012069.2|WP_050343237.1|612360_613692_+|ATP-binding-cassette-domain-containing-protein
MGSELLLPGPVRTLVALGGVIRSSRFVSTVGITALRITLGFLLGFSCAVVLGIVSHVSRTMHELVAPAVSTLKSVPVVCIIVLLLIWVGATSVSWIVVFLAIFPALYFSVVEGLENVDAKVAGMLERLRVSRPRRLLALGWPEALPYVRAASKNACGMAWKAGIAAEVVGTPAGSVGERIYQAKLLLETSDVFAWTIIVVLAAFLCERAFLAVLELTGPLSLRASVMGLGRRRTRDAAGIPQDGRIELDDVTLGYEGTVVAEHVSLQLGMRSRVLLDDASGAGKTTLLRTVLGELSPLGGCVRACERISAVWQEVRLIEGLDAIDNVLLVAGATIDRGKARALLVELLPKGLLHLPVRQLSGGQRRRVELARALAYRSEAVLLDEPFASLDESSHRRAAGFVLRHLGGRPLLVASHLPEDVKLLGAKVFSLGQPHAVSEGAGA
>NZ_CP012069.2|WP_050344707.1|613815_614613_+|ADP-ribosylglycohydrolase-family-protein
MDTTRPRELRDAVLGEAVGDALGVPFEFRERDSFECTGMTGGGSHAQPAGTWSDDSAMMLATCDSIKTCGRVDVDDMRLRFEAWLRMGSYAIDGVFDVGCTTSSALQAGHGMKGEWDNGNGSLMRIAPLAFCDATDDEVRDVSGITHAHHVSYETCVEFVHVLREAIADPVALHARLVAEHGETPRRRIRSGGFVRDTYEAALWCVGTTQSYRDCVLAAVNLGDDTDTTAAVAGALAGTIYGATSIPEEWLDVLRGTEIIESCLF

Crispr_ID: NZ_CP012069_12

• CRISPR_ID: NZ_CP012069_12
• CRISPR_location: 665630-665716
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_12

Consensus_repeat	Method
GCCCCGCAGGCTGGCGGGGGGTTGC	CRISPRCasFinder

spacers of NZ_CP012069_12

>12.1|665655|37|NZ_CP012069|CRISPRCasFinder
TCGAGCGCATCTGCCCAGTTGAGCCATTCTCCATAGT

CRISPR arrays and Neighbor proteins around NZ_CP012069_12

CRISPR arrays

The CRISPR arrays of NZ_CP012069_12

>merge|NZ_CP012069|12|665630-665716|CRISPRCasFinder
GCCCCGCAGGCTGGCGGGGGGTTGCTCGAGCGCATCTGCCCAGTTGAGCCATTCTCCATAGTGCCCCGCAGCCTGGCGGGGGGTTGC

>NZ_CP012069|12|9|665630-665716|CRISPRCasFinder
GCCCCGCAGGCTGGCGGGGGGTTGC	TCGAGCGCATCTGCCCAGTTGAGCCATTCTCCATAGT
GCCCCGCAGCCTGGCGGGGGGTTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050343317.1|662828_663746_+|PTS-mannose/fructose/sorbose-transporter-family-subunit-IID	unknown	unknown	gnl|CDD|226239
NZ_CP012069.2|WP_050344714.1|668692_669883_+|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|180261
NZ_CP012069.2|WP_050343334.1|676808_677600_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl|CDD|238847
NZ_CP012069.2|WP_050343308.1|657890_658439_+|shikimate-kinase	unknown	unknown	gnl|CDD|234654
NZ_CP012069.2|WP_083444082.1|666564_666981_+|DUF956-family-protein	unknown	unknown	gnl|CDD|368754
NZ_CP012069.2|WP_050343316.1|661981_662806_+|PTS-mannose/fructose/sorbose-transporter-subunit-IIC	unknown	unknown	gnl|CDD|237895
NZ_CP012069.2|WP_050343330.1|674066_675512_+|FAD-binding-oxidoreductase	unknown	unknown	gnl|CDD|223354
NZ_CP012069.2|WP_050343329.1|672750_673758_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl|CDD|224936
NZ_CP012069.2|WP_083444081.1|663907_664858_-|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl|CDD|224399
NZ_CP012069.2|WP_050343332.1|675593_676733_+|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|173847
NZ_CP012069.2|WP_050343310.1|658435_659539_+|hypothetical-protein	unknown	unknown	gnl|CDD|273575
NZ_CP012069.2|WP_050343314.1|660964_661966_+|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl|CDD|185045
NZ_CP012069.2|WP_050343328.1|671868_672669_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl|CDD|224997
NZ_CP012069.2|WP_050343321.1|667274_668621_+|butyryl-CoA:acetate-CoA-transferase	unknown	unknown	gnl|CDD|188463
NZ_CP012069.2|WP_050343306.1|657307_657808_+|YqeG-family-HAD-IIIA-type-phosphatase	unknown	unknown	gnl|CDD|225090
NZ_CP012069.2|WP_050343312.1|659632_660754_+|aminopeptidase-P-family-protein	unknown	unknown	gnl|CDD|238525
NZ_CP012069.2|WP_050343325.1|670753_671623_+|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|180269
NZ_CP012069.2|WP_083443766.1|655907_657296_+|endolytic-transglycosylase-MltG	unknown	unknown	gnl|CDD|376862
NZ_CP012069.2|WP_050343301.1|655483_655915_+|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl|CDD|335420
NZ_CP012069.2|WP_050343323.1|669892_670678_+|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|180270

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050343317.1|662828_663746_+|PTS-mannose/fructose/sorbose-transporter-family-subunit-IID	gnl|CDD|226239	COG3716, ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism].	4.38871e-135
NZ_CP012069.2|WP_050344714.1|668692_669883_+|acetyl-CoA-C-acetyltransferase	gnl|CDD|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NZ_CP012069.2|WP_050343334.1|676808_677600_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl|CDD|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	5.80042e-66
NZ_CP012069.2|WP_050343308.1|657890_658439_+|shikimate-kinase	gnl|CDD|234654	PRK00131, aroK, shikimate kinase; Reviewed.	3.72474e-41
NZ_CP012069.2|WP_083444082.1|666564_666981_+|DUF956-family-protein	gnl|CDD|368754	pfam06115, DUF956, Domain of unknown function (DUF956). Family of bacterial sequences with undetermined function.	4.26611e-49
NZ_CP012069.2|WP_050343316.1|661981_662806_+|PTS-mannose/fructose/sorbose-transporter-subunit-IIC	gnl|CDD|237895	PRK15065, PRK15065, mannose/fructose/sorbose family PTS transporter subunit IIC.	1.66829e-128
NZ_CP012069.2|WP_050343330.1|674066_675512_+|FAD-binding-oxidoreductase	gnl|CDD|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.38286e-114
NZ_CP012069.2|WP_050343329.1|672750_673758_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl|CDD|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	1.07424e-131
NZ_CP012069.2|WP_083444081.1|663907_664858_-|class-I-mannose-6-phosphate-isomerase	gnl|CDD|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	2.24642e-98
NZ_CP012069.2|WP_050343332.1|675593_676733_+|acyl-CoA-dehydrogenase-family-protein	gnl|CDD|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.78077e-157
NZ_CP012069.2|WP_050343310.1|658435_659539_+|hypothetical-protein	gnl|CDD|273575	TIGR01357, 3-dehydroquinate_synthase, 3-dehydroquinate synthase. This model represents 3-dehydroquinate synthase, the enzyme catalyzing the second of seven steps in the shikimate pathway of chorismate biosynthesis. Chorismate is the last common intermediate in the biosynthesis of all three aromatic amino acids. [Amino acid biosynthesis, Aromatic amino acid family].	1.2367e-05
NZ_CP012069.2|WP_050343314.1|660964_661966_+|PTS-sugar-transporter-subunit-IIB	gnl|CDD|185045	PRK15088, PRK15088, PTS system mannose-specific transporter subunits IIAB; Provisional.	5.34779e-86
NZ_CP012069.2|WP_050343328.1|671868_672669_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl|CDD|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	3.76956e-91
NZ_CP012069.2|WP_050343321.1|667274_668621_+|butyryl-CoA:acetate-CoA-transferase	gnl|CDD|188463	TIGR03948, hypothetical_protein_FAEPRAM212_02812, butyryl-CoA:acetate CoA-transferase. This enzyme represents one of at least two mechanisms for reclaiming CoA from butyryl-CoA at the end of butyrate biosynthesis (an important process performed by some colonic bacteria), namely transfer of CoA to acetate. An alternate mechanism transfers the butyrate onto inorganic phosphate, after which butyrate kinase transfers the phosphate onto ADP, creating ATP. [Energy metabolism, Fermentation].	0
NZ_CP012069.2|WP_050343306.1|657307_657808_+|YqeG-family-HAD-IIIA-type-phosphatase	gnl|CDD|225090	COG2179, COG2179, Predicted hydrolase of the HAD superfamily [General function prediction only].	3.1743e-43
NZ_CP012069.2|WP_050343312.1|659632_660754_+|aminopeptidase-P-family-protein	gnl|CDD|238525	cd01092, APP-like, Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.	1.83824e-100
NZ_CP012069.2|WP_050343325.1|670753_671623_+|3-hydroxybutyryl-CoA-dehydrogenase	gnl|CDD|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	6.06438e-138
NZ_CP012069.2|WP_083443766.1|655907_657296_+|endolytic-transglycosylase-MltG	gnl|CDD|376862	pfam02618, YceG, YceG-like family. This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of YceG was solved by X-ray crystallography.	8.91224e-99
NZ_CP012069.2|WP_050343301.1|655483_655915_+|Holliday-junction-resolvase-RuvX	gnl|CDD|335420	pfam03652, RuvX, Holliday junction resolvase. This family of nucleases resolves the Holliday junction intermediates in genetic recombination.	1.35873e-43
NZ_CP012069.2|WP_050343323.1|669892_670678_+|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|180270	PRK05809, PRK05809, short-chain-enoyl-CoA hydratase.	3.32931e-118

Protein sequences

>NZ_CP012069.2|WP_083444081.1|663907_664858_-|class-I-mannose-6-phosphate-isomerase
MDLIRIEPVFHEKIWGGRKLETEFGYTIPDGPIGECWAISAHPAGDCHVRDGAYAGMLLSSLWTEHHELFGAAEGDRFPLLIKFLDAAKDLSIQVHPDDAYAAEHEGGSLGKCECWYVLHADPNATIVVGQRAKSPEEFGRLVEEGRWSELLNEVPVHAGDFFQIAPGTVHAIKGGTMVLETQQSSDITYRVYDYDRVQADGTKRELHLQKSLDVIDFGAKPITSGRVSAPTTNGITQLVCCPRYTVWHVRATGTATLSSPKTFYCASVIEGTGRASDHELRKGDHFIVPAGYGTLRLEGDMQLIVSTVPANEQAA
>NZ_CP012069.2|WP_050343317.1|662828_663746_+|PTS-mannose/fructose/sorbose-transporter-family-subunit-IID
MADKIKLSKKVRRAVCNRHQYLQGSWNYERMQNGGWCYSMIPAIKALYKDPEDQKAALNRHLEFYNTHPYVSAPVIGVTLAMEEERANGASIDDVAIQGVKVGMMGPLAGVGDPVFWFTVRPILGALGASLALGGSIIGPILFFVLWNIIRIAFLWYTQEFGYNVGTSITKDLSGGLLGKITEGASILGMFIIGALVERWVSISFTPVVARIPQQEGAYIDWDKLPSGAEGIKEALTQYSSLGANGLGAEKVTTLQQNLDQLIPGIAAVGLTLLCCWLLKKKVSPIAIILALFAVGIIGRVLQFM
>NZ_CP012069.2|WP_050343316.1|661981_662806_+|PTS-mannose/fructose/sorbose-transporter-subunit-IIC
MSPVSIVLIVIVAFLAGMEGILDEWQFHQPLVACTLIGIVTGHPVEGITLGGSLQMIALGWANVGAAVAPDAALASIASSILMVLALGNGGASSEATKNAITTSIALAVPLSVAGLFLTMICRTIATGIAHAMDGCAERNDMGGIERWQIAAIGLQGLRIAIPAAALCVIPSDVVSSTLSKMPEWLSGGMAVGGGMVAAVGYAMVINMMATKETWPFFALGFVFAALKELTLIALGVIGVCLALIYLGLKGLAASGSGSGGGSGDPLGDVLDSY
>NZ_CP012069.2|WP_050343314.1|660964_661966_+|PTS-sugar-transporter-subunit-IIB
MVGIILASHGAFAEGIKESGQMIFGAQEDVAAVVLTPDMGPDDMHKKLLDAIGSFGDQEHVLFLVDLWGGTPFNQVSRIIDEEGHDDWVAIMGLNLPMLIAAYGARMGAETAVDVVNEVYPEAQGGVKVKPESLQPAAPAAATAAAPAAVPTGSIPEGTVLGDGHIKVVLARVDTRLLHGQVATTWTKMTGPDRIIVCSDAVSKDELRKSMIIQAAPPGVKVHVVPVSKIIEVAHDPRFGATKALLLFETPQDALRAIEGGVPIKELNLGSMAHSVGKVVVTQALAMDQNDLDTLEKIKDANVSFDVRKVPADKAENFDALIKKAKEELAAQK
>NZ_CP012069.2|WP_050343312.1|659632_660754_+|aminopeptidase-P-family-protein
MNDQQELARRVQRVRDLMTERGYDAIILRNNPDLRWLTGAVRCFDDEPAHVAFVTQDSLRLHTDSRYYNSFLERMGEDSSWLIDMQTIAAPEWAAARIESDRARVVAIEDTASVSFLDDLKVACSARGIACLLPRLHSDIVRLRIVKSESEIGLMRRAQAITDLAFEHICGFIRAGLSEQQLRAELESFMLANGADALSFETIVAAGPNGANPHARPSGYIIQEGDMVVMDYGAGYLDYHSDMTRTVCVGEPGEEQRRVYDVVRFAHETCAAALKPDCKGRDIHELAVKVITDAGYGEYFNHGLGHGVGLEIHEQPSLGRLYDKPVPKGSVVTIEPGIYLPGRFGVRLEDFGVVGEDGFKPLTRSSHELRIVG
>NZ_CP012069.2|WP_050343310.1|658435_659539_+|hypothetical-protein
MSEGLKAVRQWVSASGGACDARLGHGVILGEAGSLFRAAVGRPRRAALVTATTDEELVELTRRELSSEGFEVAGITLSETGEMRCLSEATQLVDSLAQAGITADDLVVAVGDCDLLSLLSAVCGSWCAGTPLAGVATDLVCAIEAVPTPRGLDAAGHAQMLEVRPWCHYLLVDFDHIELALRDERVREALALMVVTAMADSEQSFSRLWDRSLDIVEGDVLALEEQVVDTLKTRGRLVSSTALAVRQSLHYASELPRAISQLFDAAGSTLLAEGMRFSARIAAGEGTLPVDDVFTQDELLDRLGLAQVEADLDADRLLAVFKEECFVRSRRLQMALPQRLGCVRLSNVTDTLLGEHLKAFCTSRAIG
>NZ_CP012069.2|WP_050343308.1|657890_658439_+|shikimate-kinase
MNGQGQGYVVHEGCDHIFFIGFLGAGKSTLARNLGALFRRSFVDTDRLVERARGKSVCDIFAEDGQDCFRRDEAAVLRGLAERKSLLVSCGGGIVEGRESCRLMHQMGTIVFLDGDLEDSLRQIRHPELRPDFRCAKDAGELYRYRYPLYQREADLTLDIRNKTFDQVCSMAGALLWEEGLL
>NZ_CP012069.2|WP_050343306.1|657307_657808_+|YqeG-family-HAD-IIIA-type-phosphatase
MGIFTAGRYIASIDLVDVDELKRVGIRCVLFDRDNTCVPRSTKQAPGAVLEWFDRAHAAGLRTCMVSNNFHSSEVIRSARELKSEVIHHAMKPFPFAVRCALDKMGVGPEEAVLIGDQLYTDIAAGNLAGVRTILVRPQSTSDLWYTHILRIFESMLLSGKIFEGE
>NZ_CP012069.2|WP_083443766.1|655907_657296_+|endolytic-transglycosylase-MltG
MAEKKRQKSSVSSRSNTGGVLTQGGTSRAVRPSNQGDSLWAVRPRPRGGSGQPSTSAREPNKPRIAGLTRRIVHRGEGGFWGPRRNVDRRIILIVAVVAVVVIAGAIAGVSRLFAHMDRPTTVANPGEVVTVTIPSGAGTADIAQILVDGGVITSTADFKKAVKDQNASTSMKSGNYDFIAGSDINDIVRQLVAGPNSSSERLTIAEGLTVTRVAATAQDALGIPKDDFLAQAKASNYAGDYPFLADVADDSLEGFLFPKTYDFGGKEVSADGVIRAMLDQHQVEFRKLDMGSAEAFIQQKYNVTMSDYDILKLASIIEKEALDDDDRYKISSVMYNRLKTGMALQSDATMGYVTGGEVTAADLKVDSPYNTYLHMGLPPTPICTPSMESIRAAMDPADTNYYFFWITEDEHVFSETYEQHEQAIQSAQGKHQNAQDQIGQDKDASSGPGDAQGGSERSQDD
>NZ_CP012069.2|WP_050343301.1|655483_655915_+|Holliday-junction-resolvase-RuvX
MRVLALDIGEVRIGIAATDASGTIACPVRVLSASEVLGQAKSFRRILEDYEPELLVCGCPKTLSGTDGPQSRRVMGQARTIAQACGLPLEFVDERLSSAEAKRILRQEGYSEKSMRGRVDMVAASLFLQTWLDMHDGKGGSDG
>NZ_CP012069.2|WP_083444082.1|666564_666981_+|DUF956-family-protein
MHSRRKDVQPLNASVDLQIKSTSFLGIASYGVLTIGNAGIEYRNDTNKSDFIQIPWGEVDHVSAPVMFGGRYLPRFTVTTRHDGEFSFSTRDNKRTLRAMRPYVGEDSLVRAHSLTASIAKYLKGLLGNRFGSSSRGS
>NZ_CP012069.2|WP_050343321.1|667274_668621_+|butyryl-CoA:acetate-CoA-transferase
MDFSEIYQSKLTTAEKAAEVVKSGDWVDCGWSPLTPVEFDAALAKRLVDLHDVNFRGGILLREPELFKIEHPEEHMSWNSWHMGGIERRACQQGFGFYSPIRYSELPRYYRDGTAKVNVACMQVSPMDEAGNFGFGLCSSHLMAACDVADVIIVEVNERVPRCFGGPESHISVTRVDMIIEGKNPPMSTLGSGGAPTEVDEAVTKLVVPMIPDGACLQLGIGSMPTTIGTGIAQSDLTNLGVHTEMYVDSFVDLAMAGKITGNRKAIDRGKQVYSFAVGSKKLYDYLDNNPECVSAPVNYVNDAHTISQLDNFISINNAVDIDLFGQVNAESAGTKAISGAGGQLDFVLGAYLSHGGKSFICMSSTFTNRKTGEVLSRIRPTLANGSIVTDTRSNTMYVVTEYGVINLKGLAAWQRAEALIGIAHPDFRDDLIKEAQKMHIWRRSNRI
>NZ_CP012069.2|WP_050344714.1|668692_669883_+|acetyl-CoA-C-acetyltransferase
MSERVVIASACRTAIGKFGGSLSTVSARTLGATVIKEALNRAKVKPEDVDHVYLGCVLQAGQGQNVARQASLDAGLPIECPAVTINVVCGSGLYSVNAAAQMIKAGDADIVVAGGTENMDMAPFALQKGRYGYRMGYPMGKSELVDTMVNDGLWDAFNNYHMGITAENVAAQWGLSREQLDEFAATSQNRACKAIADGAFKDEIVPVTVKQRKKEIVFDTDEGPREGSTVETLAKLRPAFKPDGIVTAGNSSAINDGAAALVVMSEKKAQELGITPLATIVSGELAGVDPSIMGTGPVPSSKKALAKAGLSINDIDLVEANEAFAAQSLAVVRDLGLDLAKTNVNGGAIALGHPVGASGARILTTLLYAMKHRGAHKGLATLCIGGGMGCATVVEM
>NZ_CP012069.2|WP_050343323.1|669892_670678_+|enoyl-CoA-hydratase/isomerase-family-protein
MSFVSCEVQDRVAVLTIDRPKALNALNPEVLNDLRLAFEGIDQDVVRCVILTGAGDKSFVAGADIASMSTMTKAEGEAFGRLGNDVFLMVENFPLPVIAAVNGFALGGGNELAMSCDIRLASENALFGQPEVGLGITPGFGGTQRLARVVGVGMAKQLVYSATNIKASEALRIGLVNAVYAPDQLMDAARKLAGKIASNAPIAVRNCKRAINEGIELPIAEAVQVEERLFGACFETHDQVEGMSCFLSREKPKPKAVFTNN
>NZ_CP012069.2|WP_050343325.1|670753_671623_+|3-hydroxybutyryl-CoA-dehydrogenase
MKVGVIGAGTMGQGIAKAFAQSGWEVALCDIKQEWADGGKAKIAKGYERLVSKGKLDQAEVDKRLAAITTGLKEALASSCDLIVEAAFEDMKVKKETFAELDKICKESCIFASNTSSLSITEIGAGLSRPLVGMHFFNPADRMKLIEVIAGVNTPVETTEKIVSIAKEIGKTPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDTAMKLGANHPMGPLELGDFIGLDICLAIMDVLYTETCDSKYRACPLIRKMVRGGNLGAKSGRGFYVYNTDRTKTPVDQL
>NZ_CP012069.2|WP_050343328.1|671868_672669_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MKLLVCVKQVPDTTEIRIDPETNRLIRDGVPSIVNPFDGYALEMAARIKDQRDDVQIIVMSMGPMQAKEALKSCLAVGGDKAYLISGRRFGGSDTLATSYILFCAIKKLEEIEGKFDVIFCGKQAIDGDTAQVGPELAEYLGVPQVTYGLTAEIVDNEIQVTRETEDGQEILGVSFPCLVTATKPSFDPRLPTIKQKLAARKKEITVFSENDFDVDLSRCGLNGSPTKVKKTFVPPVKQGGIRIQAETAGEAAQKLAEHLDADNVL
>NZ_CP012069.2|WP_050343329.1|672750_673758_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MEPKSKDLWVFIETFADGSAQNVGLELLNPGRDLVNKQGGKLVALVIGHNTDAAVVSAQEHGADQVIVVDGPEYEHYTTDAYVNALAAMLTKYAPTTMLIGATNNGRDVGPRLSSRLQTGLTADCTQLAIDEESGNVAWTRPAFGGNLMARILCPNHRPQLGTVRPGVFKALPPEAGRSCEVVREDFHVAPEDIHVRLIKEIQEGASELVDLIGAEIIVSGGRGVGGAEGFEPLKGLADALGATVGCSRAAVDAGWISHSHQVGQTGKTVGPKLYIACGISGAIQHVAGMSSSDVIVAINKDPEAPIFDIADYGIVGDLFEVVPALTEAIKKVKG
>NZ_CP012069.2|WP_050343330.1|674066_675512_+|FAD-binding-oxidoreductase
MATYTYNKVTPEVLEQIKAAANGHVLVGDQINEDFSHDEMRIYGEAMPEVLVEPTTTEEVAAVMKVCNENKIAVTPSGARTALTGGPVAQYGGVMISTTKMNKILGYDEENLVVTIQPGVLLKDLADDALKRGLMYPPDPGEKLATVGGNVSTNAGGMRAVKYGTTRDYVKEITVVLPTGEVVKEGATVSKTSSGYSLLHLLIGSEGTLGIITEMTLKIIVAPKMTMSIIVPYETLEGAIATVPKLFAANLDPQALEFMEKDVVIDTEQLLSKEVYPKQLNGVDINAYVLATFDGSDEDQLMNTIEEASNIALEAGAVDVLVADTPQQLRDAWAIRSSLLESIEGNTKLLDECDVVVPVTKIPEFLTYAKSLGEGHSYTVKDFGHAGDGNLHIYLCSNDDDAEAFMKESDEFMKKAYAKAVELGGLISGEHGIGSGKISYLKDFVGPVNMRLMRGIKKVFDPNMILNPGKVCFIPEEDEDE
>NZ_CP012069.2|WP_050343332.1|675593_676733_+|acyl-CoA-dehydrogenase-family-protein
MAYFISDEAKDLLGDLKKFCDAEVVEQAKEYDKSGEWPKDIYDKAIEQGYTTLEVPEEFGGPGLSRVDVAALIEQMAWADSGFATTISASGLGTKPVLIAGNEAQKKHVCDLLLEGGFGAFCLTEPGAGSDPGAGTTTAVKDGDGYVLNGRKCFITNGAVASFYCVTALTDKEKGAKGMSIFLVDRDTPGLSVGHEEDKMGIRLSNTTDVVLEDVHVPAENLLGGEGQGFKISMQTLDQARAWMGVVSTGLAQRAMDEAIAYTKERKQFGRPVLKFQAMQFKIADMAMKIEAGRQLCAYALNLMDQGKAHSREAAMAKCFASDAAMWCTTEAVQMLGGYGYSREYPVEKLMRDAKIFQIFEGTNEVQRIVTANNTIGRF
>NZ_CP012069.2|WP_050343334.1|676808_677600_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNILVCIKQVPDDSVEVGFGKDGKPAIEGITPVVNAFDTYALEMATRLKESLGDGSEITVLCVGPDSAKNSLKNCLAVGGDYAYLVSEEGVSDTDNLGIAELIRGAIEKLRGERGDFDLVFAGKEATDVAQGQTGIYLAAKLNVAVATDAIDITREGDTVQVKHETDEGYRLVELPLPALVTVSKPSYDPRYPTIRNKMAARKKPIGELSGAELAQGADIAARLSTVREYEPPKRAAGVKIQEETVEESTAKAIQMMVDARVL

Crispr_ID: NZ_CP012069_13

• CRISPR_ID: NZ_CP012069_13
• CRISPR_location: 687144-687231
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_13

Consensus_repeat	Method
GGCAACCGCCCGCCAGGATGCGGGGC	CRISPRCasFinder

spacers of NZ_CP012069_13

>13.1|687170|36|NZ_CP012069|CRISPRCasFinder
ACTATGGAAAATGGCCCAACTGGGCAAACGCGCCCG

CRISPR arrays and Neighbor proteins around NZ_CP012069_13

CRISPR arrays

The CRISPR arrays of NZ_CP012069_13

>merge|NZ_CP012069|13|687144-687231|CRISPRCasFinder
GGCAACCGCCCGCCAGGATGCGGGGCACTATGGAAAATGGCCCAACTGGGCAAACGCGCCCGGGCAACCGCCCGCCAGGCTGCGGGGC

>NZ_CP012069|13|10|687144-687231|CRISPRCasFinder
GGCAACCGCCCGCCAGGATGCGGGGC	ACTATGGAAAATGGCCCAACTGGGCAAACGCGCCCG
GGCAACCGCCCGCCAGGCTGCGGGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050343336.1|678903_680463_+|L-lactate-permease	unknown	unknown	gnl|CDD|224535
NZ_CP012069.2|WP_050343335.1|677610_678603_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl|CDD|224936
NZ_CP012069.2|WP_050343334.1|676808_677600_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl|CDD|238847
NZ_CP012069.2|WP_050344715.1|684118_685261_+|ATP-binding-protein	unknown	unknown	gnl|CDD|379306
NZ_CP012069.2|WP_157051372.1|680667_682851_+|hypothetical-protein	unknown	unknown	gnl|CDD|375359
NZ_CP012069.2|WP_172674431.1|697672_698641_+|hypothetical-protein	unknown	unknown	gnl|CDD|234686
NZ_CP012069.2|WP_050343330.1|674066_675512_+|FAD-binding-oxidoreductase	unknown	unknown	gnl|CDD|223354
NZ_CP012069.2|WP_050343352.1|696588_697152_+|elongation-factor-P	unknown	unknown	gnl|CDD|234788
NZ_CP012069.2|WP_050343332.1|675593_676733_+|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|173847
NZ_CP012069.2|WP_050343329.1|672750_673758_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl|CDD|224936
NZ_CP012069.2|WP_083443767.1|698958_699855_+|TlyA-family-RNA-methyltransferase	unknown	unknown	gnl|CDD|224110
NZ_CP012069.2|WP_050343347.1|692464_693586_+|[FeFe]-hydrogenase-H-cluster-radical-SAM-maturase-HydE	unknown	unknown	gnl|CDD|274880
NZ_CP012069.2|WP_050343328.1|671868_672669_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl|CDD|224997
NZ_CP012069.2|WP_050343348.1|693639_695106_+|[FeFe]-hydrogenase-H-cluster-radical-SAM-maturase-HydG	unknown	unknown	gnl|CDD|274879
NZ_CP012069.2|WP_050343341.1|688247_690512_-|formate-C-acetyltransferase	unknown	unknown	gnl|CDD|153087
NZ_CP012069.2|WP_050343345.1|691434_692136_-|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223736
NZ_CP012069.2|WP_050343339.1|682925_683666_-|prepilin-peptidase	unknown	unknown	unknown
NZ_CP012069.2|WP_050343353.1|697304_697667_+|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl|CDD|377129
NZ_CP012069.2|WP_050343350.1|695115_696354_+|[FeFe]-hydrogenase-H-cluster-maturation-GTPase-HydF	unknown	unknown	gnl|CDD|274853
NZ_CP012069.2|WP_050343343.1|690536_691280_-|pyruvate-formate-lyase-activating-protein	unknown	unknown	gnl|CDD|131546

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050343336.1|678903_680463_+|L-lactate-permease	gnl|CDD|224535	COG1620, LldP, L-lactate permease [Energy production and conversion].	2.86506e-117
NZ_CP012069.2|WP_050343335.1|677610_678603_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl|CDD|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	1.36405e-101
NZ_CP012069.2|WP_050343334.1|676808_677600_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl|CDD|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	5.80042e-66
NZ_CP012069.2|WP_050344715.1|684118_685261_+|ATP-binding-protein	gnl|CDD|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	3.5962e-51
NZ_CP012069.2|WP_157051372.1|680667_682851_+|hypothetical-protein	gnl|CDD|375359	pfam17823, DUF5585, Family of unknown function (DUF5585). This is a family of unknown function found in chordata.	0.000369181
NZ_CP012069.2|WP_172674431.1|697672_698641_+|hypothetical-protein	gnl|CDD|234686	PRK00202, nusB, transcription antitermination factor NusB.	3.24674e-27
NZ_CP012069.2|WP_050343330.1|674066_675512_+|FAD-binding-oxidoreductase	gnl|CDD|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.38286e-114
NZ_CP012069.2|WP_050343352.1|696588_697152_+|elongation-factor-P	gnl|CDD|234788	PRK00529, PRK00529, elongation factor P; Validated.	4.62088e-96
NZ_CP012069.2|WP_050343332.1|675593_676733_+|acyl-CoA-dehydrogenase-family-protein	gnl|CDD|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.78077e-157
NZ_CP012069.2|WP_050343329.1|672750_673758_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl|CDD|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	1.07424e-131
NZ_CP012069.2|WP_083443767.1|698958_699855_+|TlyA-family-RNA-methyltransferase	gnl|CDD|224110	COG1189, COG1189, Predicted rRNA methylase [Translation, ribosomal structure and biogenesis].	1.64965e-94
NZ_CP012069.2|WP_050343347.1|692464_693586_+|[FeFe]-hydrogenase-H-cluster-radical-SAM-maturase-HydE	gnl|CDD|274880	TIGR03956, iron-only_hydrogenase_maturation_rSAM_protein_HydE, [FeFe] hydrogenase H-cluster radical SAM maturase HydE. This model describes the radical SAM protein HydE, one of a pair of radical SAM proteins, along with GTP-binding protein HydF, for maturation of [Fe] hydrogenase in Chlamydomonas reinhardtii and numerous bacteria. [Protein fate, Protein modification and repair].	0
NZ_CP012069.2|WP_050343328.1|671868_672669_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl|CDD|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	3.76956e-91
NZ_CP012069.2|WP_050343348.1|693639_695106_+|[FeFe]-hydrogenase-H-cluster-radical-SAM-maturase-HydG	gnl|CDD|274879	TIGR03955, iron-only_hydrogenase_maturation_rSAM_protein_HydG, [FeFe] hydrogenase H-cluster radical SAM maturase HydG. This model describes the radical SAM protein HydG. It is part of an enzyme metallocenter maturation system, working together with GTP-binding protein HydF and another radical SAM enzyme, HydE, in H-cluster maturation in [FeFe] hydrogenases. [Protein fate, Protein modification and repair].	0
NZ_CP012069.2|WP_050343341.1|688247_690512_-|formate-C-acetyltransferase	gnl|CDD|153087	cd01678, PFL1, Pyruvate formate lyase 1. Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. The PFL mechanism involves an unusual radical cleavage of pyruvate in which two cysteines and one glycine form radicals that are required for catalysis. PFL has a ten-stranded alpha/beta barrel domain that is structurally similar to those of all three ribonucleotide reductase (RNR) classes as well as benzylsuccinate synthase and B12-independent glycerol dehydratase.	0
NZ_CP012069.2|WP_050343345.1|691434_692136_-|Crp/Fnr-family-transcriptional-regulator	gnl|CDD|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	7.92587e-30
NZ_CP012069.2|WP_050343353.1|697304_697667_+|Asp23/Gls24-family-envelope-stress-response-protein	gnl|CDD|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	1.46819e-09
NZ_CP012069.2|WP_050343350.1|695115_696354_+|[FeFe]-hydrogenase-H-cluster-maturation-GTPase-HydF	gnl|CDD|274853	TIGR03918, hydrogenase_maturation_GTPase_HydF, [FeFe] hydrogenase H-cluster maturation GTPase HydF. This model describes the family of the [Fe] hydrogenase maturation protein HypF as characterized in Chlamydomonas reinhardtii and found, in an operon with radical SAM proteins HydE and HydG, in numerous bacteria. It has GTPase activity, can bind an 4Fe-4S cluster, and is essential for hydrogenase activity. [Protein fate, Protein modification and repair].	0
NZ_CP012069.2|WP_050343343.1|690536_691280_-|pyruvate-formate-lyase-activating-protein	gnl|CDD|131546	TIGR02493, PFLA, pyruvate formate-lyase 1-activating enzyme. An iron-sulfur protein with a radical-SAM domain (pfam04055). A single glycine residue in EC 2.3.1.54, formate C-acetyltransferase (formate-pyruvate lyase), is oxidized to the corresponding radical by transfer of H from its CH2 to AdoMet with concomitant cleavage of the latter. The reaction requires Fe2+. The first stage is reduction of the AdoMet to give methionine and the 5'-deoxyadenosin-5-yl radical, which then abstracts a hydrogen radical from the glycine residue. [Energy metabolism, Anaerobic, Protein fate, Protein modification and repair].	5.66866e-104

Protein sequences

>NZ_CP012069.2|WP_050344715.1|684118_685261_+|ATP-binding-protein
MAGWFPVVSVTGPRQSGKSTLVRKVFSEYDYVNLENIDTREAALADPVGFIRDRPQRLVIDEAQLAPELFNMIQVVSDETGEPGQYILSGSQNFLLLRSITQSLAGRVGLLRLMPLSFAEARAEQGDLGLDDFMRKGGYPRLYDRKIPARVYYDGYVSTYLERDVAGYLDVRNIRQFETMLRLVAQTAGGLLNITRLAQDASVSSKTAREWLSILESSYIIFLLPPYFANIRKRLVKTPKLYLNDTGLLCHLLGIRSFEQLRDSPMRGAVFENLIIAESMKQYLNAGVVPEMYFYRDSRGKEVDLVDLTNAPKLVEIKSSRTFRGTFSATVNELASLVPGGVPKECRYVVMRRDDDIVVGDVQVVSAESWLLRCPDVSYR
>NZ_CP012069.2|WP_050343339.1|682925_683666_-|prepilin-peptidase
MTAILITTALYGIVIGLCAEGISQRATEHVCHRKGLAGPDIDPSRRDALRLALPLTHIAACAAMGLLASRSLPASTPLASMPMAQSLIGCMLLTTVIVAVWIELTINIIPNELVILTLLLGLAYRVLSGWLRGDVLSSLLGSLGAFMITLVLFVCSIASALKASNGISHGVGAGAFKMALALSVAVGFPGVVFFYLGLFATVAVYFLFKLLTGSYSFLTEFPLSPFLFLGLLCGLACPYLLPAIWP
>NZ_CP012069.2|WP_157051372.1|680667_682851_+|hypothetical-protein
MSRQAQVSRMLQEAVGKRLASAPGEGVWRTSCWVIPKLSVGLVSAALGFTLVFGGAGARSALAQEATPGSGATAEAVASGPEESSSIEDTGVPTAPSNKTEKTEKSEFGSPRAKGQQASAKPVSEATNSSKGSDVESIGSTTAVQDTTSSDQSGPAPSTSDIPVSSSSAAAGSSHVAAAPAADTLSADVSTTNVPATDTPTVDNTSVADVSSKKDVTSVARDSGSTTQASHSNVYRMYNAWTGEHLYTGSLSEAKSALSEGWRWEGVAWVAPSAGVPVYRLYNAWSGDHLYTTSKAEYSRLARVGWKGEGVQLYGAPAGSGAAISRLYNRYVQTGSHLLTADANEKRSCIRAGWSDDGNSWYASKLSKLPIAGFWTVTQAWTPGQLQRYWIGSDAVVAASRLIDPSSSPVDRGAGYRAWATASGAVIRGAREQGGVIYLADNDGRLATGSGWLITDRFGQGMQRYYLYSRGAYSVAKPGVSRDGATGRGGIGAYHFTTGAGHVLRGSLRSGSIIYLADNDGRLATGSGWLVTDRFCQGLQRYYLYSRGAYSVAQLGRSSDGESDIGGAHYTTTAGYVLRNMDFDDGMSWFWANNDGRMSDVTDAQRDLVSVAYSTPSPGAGLCAMWVSQVFSRAGYRYAGGNADDMYWRWCHSSDRAQLRVGMVIAVPSHSHSRMGSIYGHIGIYVGRGQVRDNVGAVRDSPLDEWIRYYSTTEVVRWGYLLGIALA
>NZ_CP012069.2|WP_050343336.1|678903_680463_+|L-lactate-permease
MLVNLLLGLVPIIWLVIALTGLKMPGYKACGIAIAFAAVVAIPYKGMAPFNCGTAILEGVLSALWPIILVIIAALFTYNLVLETGAMDRIKAMLSSISSDKRILAIIIGWSFGCFMEGMAGFGTAVAIPASILIALGFEPLPTLVGLLIVNSTPTAFGSVGVPTTTLAPLIGVDSVLLSANTALIEALLMFLSPFFMVFVIGKGFKAFKGVLPIALVSSLAFTVPNFLVATFIGPELPDIIGSGCSMAITIPLAIAMRNKPVPDEYRIAADKQQKLSISVAEGVKAWSPFILIFILLLGTSKLVPPVNAPLSAIKSSVLIYTGPTGKPTNFSWINTPGVWIIIAAIIGGLIQGARPQKIASVFGHTVASNVKTIVTICSVLATAKIMVHSGMTKDVAEALVAITGGIFPLFSPLVGVLGAFVTGSGTNTGVLFGPLQQETASRIGVVPQWLCAANAMGAGIGKMVAPSNVALACAAAGIAGQESKVIRAVFKYTLIYTVIGGIICFALAHAVTLASVVP
>NZ_CP012069.2|WP_050343335.1|677610_678603_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MKREDTKDVLVYIEVADGSPVKASLESLTPARSIADARGEGVVAVVLGSGREAAANEVAMAGADRVIYVDSSELQDFNLDAYADVLGQIVEAERPAVVLIGGTTDGKDLAPMLAARFQSASASDVIAVAAEGKDVTYTMTEYSGTVLSDVKIDAAPEIATIRSGAFKKLDEPAQGKVVSGSYAVSDGAVRAKVIDTVQEITESVNLEDAEVIVSGGRGLGSKEGFALVEELAGVLGGEVGATRPAIEDGWIAKNHQVGQSGKCVAPKLYIAAGVSGATQHLSGITGADYIVAINRDEDAPIFSVANVGIIGDALKVLPLMIEEVKKIKES
>NZ_CP012069.2|WP_050343334.1|676808_677600_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNILVCIKQVPDDSVEVGFGKDGKPAIEGITPVVNAFDTYALEMATRLKESLGDGSEITVLCVGPDSAKNSLKNCLAVGGDYAYLVSEEGVSDTDNLGIAELIRGAIEKLRGERGDFDLVFAGKEATDVAQGQTGIYLAAKLNVAVATDAIDITREGDTVQVKHETDEGYRLVELPLPALVTVSKPSYDPRYPTIRNKMAARKKPIGELSGAELAQGADIAARLSTVREYEPPKRAAGVKIQEETVEESTAKAIQMMVDARVL
>NZ_CP012069.2|WP_050343332.1|675593_676733_+|acyl-CoA-dehydrogenase-family-protein
MAYFISDEAKDLLGDLKKFCDAEVVEQAKEYDKSGEWPKDIYDKAIEQGYTTLEVPEEFGGPGLSRVDVAALIEQMAWADSGFATTISASGLGTKPVLIAGNEAQKKHVCDLLLEGGFGAFCLTEPGAGSDPGAGTTTAVKDGDGYVLNGRKCFITNGAVASFYCVTALTDKEKGAKGMSIFLVDRDTPGLSVGHEEDKMGIRLSNTTDVVLEDVHVPAENLLGGEGQGFKISMQTLDQARAWMGVVSTGLAQRAMDEAIAYTKERKQFGRPVLKFQAMQFKIADMAMKIEAGRQLCAYALNLMDQGKAHSREAAMAKCFASDAAMWCTTEAVQMLGGYGYSREYPVEKLMRDAKIFQIFEGTNEVQRIVTANNTIGRF
>NZ_CP012069.2|WP_050343330.1|674066_675512_+|FAD-binding-oxidoreductase
MATYTYNKVTPEVLEQIKAAANGHVLVGDQINEDFSHDEMRIYGEAMPEVLVEPTTTEEVAAVMKVCNENKIAVTPSGARTALTGGPVAQYGGVMISTTKMNKILGYDEENLVVTIQPGVLLKDLADDALKRGLMYPPDPGEKLATVGGNVSTNAGGMRAVKYGTTRDYVKEITVVLPTGEVVKEGATVSKTSSGYSLLHLLIGSEGTLGIITEMTLKIIVAPKMTMSIIVPYETLEGAIATVPKLFAANLDPQALEFMEKDVVIDTEQLLSKEVYPKQLNGVDINAYVLATFDGSDEDQLMNTIEEASNIALEAGAVDVLVADTPQQLRDAWAIRSSLLESIEGNTKLLDECDVVVPVTKIPEFLTYAKSLGEGHSYTVKDFGHAGDGNLHIYLCSNDDDAEAFMKESDEFMKKAYAKAVELGGLISGEHGIGSGKISYLKDFVGPVNMRLMRGIKKVFDPNMILNPGKVCFIPEEDEDE
>NZ_CP012069.2|WP_050343329.1|672750_673758_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MEPKSKDLWVFIETFADGSAQNVGLELLNPGRDLVNKQGGKLVALVIGHNTDAAVVSAQEHGADQVIVVDGPEYEHYTTDAYVNALAAMLTKYAPTTMLIGATNNGRDVGPRLSSRLQTGLTADCTQLAIDEESGNVAWTRPAFGGNLMARILCPNHRPQLGTVRPGVFKALPPEAGRSCEVVREDFHVAPEDIHVRLIKEIQEGASELVDLIGAEIIVSGGRGVGGAEGFEPLKGLADALGATVGCSRAAVDAGWISHSHQVGQTGKTVGPKLYIACGISGAIQHVAGMSSSDVIVAINKDPEAPIFDIADYGIVGDLFEVVPALTEAIKKVKG
>NZ_CP012069.2|WP_050343328.1|671868_672669_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MKLLVCVKQVPDTTEIRIDPETNRLIRDGVPSIVNPFDGYALEMAARIKDQRDDVQIIVMSMGPMQAKEALKSCLAVGGDKAYLISGRRFGGSDTLATSYILFCAIKKLEEIEGKFDVIFCGKQAIDGDTAQVGPELAEYLGVPQVTYGLTAEIVDNEIQVTRETEDGQEILGVSFPCLVTATKPSFDPRLPTIKQKLAARKKEITVFSENDFDVDLSRCGLNGSPTKVKKTFVPPVKQGGIRIQAETAGEAAQKLAEHLDADNVL
>NZ_CP012069.2|WP_050343341.1|688247_690512_-|formate-C-acetyltransferase
MQEAWNGFTGGHWVDDVNVRDFIQRNYTQYEGDESFLAGPTEATDKLWGRLQELQAEERKHDGVLDCETEVVSSLTAYGPGYIDESMKELEKVVGLQTDKPLKRAFMPYGGIKMAQEAAENYGYHINDKYNKIFNEYHKTHNQAVFDAYTPEMRAARHSHIVTGLPDTYGRGRIVGDYRRVALYGIDFLIAKKQEDLLNCGNGTMTDDIIRLREEIADQIRALKGMKEMAKIYGYDISAPAKDAHEAVQWLYFGYLAAIKTQNGAAMSVGRISTFLDIYIERDLKAGKLTETEAQELIDHMVLKFRMVKFARIPSYNQLFSGDPVWATLEMAGLGMDGRHMVTKSDYRFLHTLENMGPAPEPNLTVLYSEMLPENFRQYAAKISIETSSIQYENDDVMRPIWGDDYSICCCVSATETGKEMQFFGARANLAKCLLYAINGGKDEKFLDKQGKHMQVGPEYAPITSEYLDYDEVMHKYDLMMDWLAGLYVNILDLIQYMHDKYYYESALMALIDTDVRRTFATGIAGFSHVVDSLCAIKYAKVKAVRDESGVATGFEVEGDFPRYGNDDARADDLAVWLLKTFMTKLRKYHTYRNSEATTSILTITSNVVYGRATGALPDGRKAYTPFAPGANPSYGAEQNGLLASLNSVAKLPYEYALDGISNTQTINPSALGTDDTQRKVNLVHVMDGYFTAGAHHLNVNVFGVDKLKDAMEHPEKPEYANFTIRVSGYAVKFIDLTREQQLDVIARTCHDHM
>NZ_CP012069.2|WP_050343343.1|690536_691280_-|pyruvate-formate-lyase-activating-protein
MLQGRVHSCESFGSADGPGVRYLIFLQGCEMRCRYCHNPDTWGKTKGSLMSADELLDQAERYRGYWGKEGGITVSGGEPLLQIDFVRELLHKAKQRNINTCIDTALQPFTREQPFFGTFEALMRDTDLLLVDIKHIDPIEHKKLTGCDNRNILDGLSYLSQIGKPIWIRHVLVPGITDNDDYLRLTREFIKGLSNVKRIDVLPYHSLGIYKWDELGIPYTLRDTKPPAVERVRNAERILQGAGDATR
>NZ_CP012069.2|WP_050343345.1|691434_692136_-|Crp/Fnr-family-transcriptional-regulator
MRRQDDFDCRHTGASCIRHVPLLSKLPEATQQELLLCAVQSSHPKGTILVHEGDPIDSVLIVQRGKIKIFRIDADGEEYVLDVLHDGQAIWHGIFLDDRSYHYSVACLTELSLCTIRRAAFEQILTLHPDVAMDLIHILSTELDGAEEKLMMLSIRDPKRRLAEYLLHRDARCLGEEIDLRLDDIARSISLRPETVSRTFTTFERKGLVARLGRGRIQIVNHQGLRDVSASIE
>NZ_CP012069.2|WP_050343347.1|692464_693586_+|[FeFe]-hydrogenase-H-cluster-radical-SAM-maturase-HydE
MVNAAALSLVDQLAERHSLSLGDYQRLIEAFSPDLAAHAAARADVQRRRYFGNAVFVRGLIEISNYCRNDCYYCGIRRSDSGIRRYRLTPTQILSCCDRGYELGFRTFVLQGGEDALFDDARLVSLILRVKRSHPDCAVTLSLGERSYESYRRLFDAGADRYLLRHETATPAHYARLHPRSLSLEHRLSCLRNLKDIGFVVGAGFMVGSPYQGRAELAADLKLIETLHPQMCGIGPFVPHHATPFRDFPRGSAELSCYLLSLLRLIKPDLLLPATTALASIDPRGCERGILAGANVIMPNLSPKEVRGDYALYDHKASTGVEAAEGLHELSRRMEAIGFRVVVDRGDPPPPLCPSRVGARHAHGAPAQAKPVT
>NZ_CP012069.2|WP_050343348.1|693639_695106_+|[FeFe]-hydrogenase-H-cluster-radical-SAM-maturase-HydG
MTEKAQSCAYDPSSSRADEFINHQEILDTLAFADEHKHDLRLIDKILDKAQPNLNPARDHCSVLSHRDAAVLLACDIPEVNERIKGLARQIKLAYYGNRIVLFAPLYLSNYCVNGCLYCPYHAKNRDIARRKLSQDEIREQVIALQDMGHKRLAIESGEDPVMSPIEYILESMKTIYSVKHRNGAIRRVNVNIAATTVDEYRMLKEAEIGTYILFQETYHKESYLALHPTGPKHDYDWHTEAMDRAMEGGIDDVGLGVLFGLEKYRYEFVGLLMHAEHLEAVWGVGPHTISVPRVKPAMDIDPASFDDGLSDDMFEKIIALIRIAVPYTGMIISTRESQAVREKALQYGISQISGGSRTSVGGYEEEERPHDTEQFDVSDQRTLDEVIHWLMECGHIPSFCTACYRAGRTGDRFMSFCKSGQILNYCQPNALMTLDEYLMDYASPTTRSLGRSLIARELTRIPDARVRRVTREHLSAIESSNARDFRF
>NZ_CP012069.2|WP_050343350.1|695115_696354_+|[FeFe]-hydrogenase-H-cluster-maturation-GTPase-HydF
MSLNDTPSSERTRIGFFGLRNAGKSSLVNAVCAQEVSVVSRISGTTTDPVRKSMELLPLGPVVIVDTPGIDDAGELGKRRVERARAELENCDIAVLVVDATRGWSPADRALAALAETCKVVRLTVWSKADLLDGETRRRLAGEPGALLVSARDGSGVNALKERLARLVRPQPPRPVVADLVGTGELVILVIPIDGSAPKGRLILPQQLVLRELLEAHAVGVCTRPEELSATMGRLGGRPRLVICDSQVFAEVARAVPRDVTLTSFSILMARHKGELAAYARGAKRLARLAGSSRVLISEGCTHHRQCQDIGTVKLPLWIEGYIGARPHFEFTSGAEFPHDPSGFDLVVHCGACMLGQREMARRIRACEGAGVPIINYGLAIAQMRGILTRSLEAFPGVGALFQAEGEGGDTS
>NZ_CP012069.2|WP_050343352.1|696588_697152_+|elongation-factor-P
MATISTADFRNGMGLKINGKYYTIVEFQHVKPGKGGAFVRYKIKDLQSGRTIDQTCNAGSKFENVQLITREMQYLYNDGTSYYFMDNETFDQIPVSEGFIGENAQWLKENDNCQLLYADTELLGVNPPMFIEAEITSTDPGFKGDTVQGGTKPATIETGATIQVPMYLNQGEKVKVDTRTGKFVSRV
>NZ_CP012069.2|WP_050343353.1|697304_697667_+|Asp23/Gls24-family-envelope-stress-response-protein
MSATELFISGIGISRGVLSTIVAHAVEKVEGVVRVGGNDIASSLVSAFTSRSVTPDAAVESSVEDGELRIVVHLAVFYGYPFTKLAADVRNAVVVAIHEQVGVEVSAVDVCIDSLMFPKE
>NZ_CP012069.2|WP_172674431.1|697672_698641_+|hypothetical-protein
MSRTSFRGRTLARSQAVQMLYQAEFTGRSVREVLSGEYVISGVFPGEYAISGVIAGRENSAEDPDDGRIWVWEQWPQSSSCRGSKGDAGDYVRVRLRRGKDKGTLIVRPKSFRILVWDSLRDGYVMALFRKGEPLILDVGPRECGISDDHSGRYLIDNAAGLVDGYAKELALGTGEIVGCLDHILNASSPNWGVSRMPSLDRNLLRLALFEMLEVDTVDISVAIDECVELAKSYGTDESSRFVNGLLGTIASQIKAGIDVLGLAREELDRKAAEAVEGDEGAGPRGDEPAGDASDDAISLVGAPLSVLASASPDSLGSQGGS
>NZ_CP012069.2|WP_083443767.1|698958_699855_+|TlyA-family-RNA-methyltransferase
MPKGRRLDEELVARGFFATREEALRSIMAGEVSTAGRRLESAGERVAADTVIHLRGRSAYVSRGGLKLERGLEALGVGPTGKACLDVGCSTGGFTDCLLRHGAASVLAVDVGYAQFDWSLRQDPRVELLERTNIVDVPSPKRAGTIDLAVCDVSFTSIRTILPAVMELLMEEGLLLALVKPQFEAGRSEVGKGGIVSDPVVQLRALKKVAGAFCEAGLVPVAACPSPICGHKGNREFLLLGARTSSQGAHVPQCGRPHQEASAPVALDLKALVYDDACVRVVDVHACPAESGVGEKGG

Crispr_ID: NZ_CP012069_14

• CRISPR_ID: NZ_CP012069_14
• CRISPR_location: 972686-972771
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_14

Consensus_repeat	Method
GCAACCCCCCGCCAGGCTGCGGGG	CRISPRCasFinder

spacers of NZ_CP012069_14

>14.1|972710|38|NZ_CP012069|CRISPRCasFinder
CACTATGGAAAATGGCCCAACTGGGCAAATGCGTCCGA

CRISPR arrays and Neighbor proteins around NZ_CP012069_14

CRISPR arrays

The CRISPR arrays of NZ_CP012069_14

>merge|NZ_CP012069|14|972686-972771|CRISPRCasFinder
GCAACCCCCCGCCAGGCTGCGGGGCACTATGGAAAATGGCCCAACTGGGCAAATGCGTCCGAGCAACCCCCCGCCAGGCTGCGGGG

>NZ_CP012069|14|11|972686-972771|CRISPRCasFinder
GCAACCCCCCGCCAGGCTGCGGGG	CACTATGGAAAATGGCCCAACTGGGCAAATGCGTCCGA
GCAACCCCCCGCCAGGCTGCGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050343768.1|969725_970904_-|phosphoribosylaminoimidazolecarboxamide-formyltransferase	unknown	unknown	gnl|CDD|180841
NZ_CP012069.2|WP_050344763.1|974392_975286_+|acetylglutamate-kinase	unknown	unknown	gnl|CDD|239783
NZ_CP012069.2|WP_050343762.1|966255_967035_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133381
NZ_CP012069.2|WP_172674436.1|971584_971761_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050344761.1|964886_965408_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NZ_CP012069.2|WP_050343787.1|983106_983955_+|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|197918
NZ_CP012069.2|WP_083444084.1|973053_974340_+|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ	unknown	unknown	gnl|CDD|376687
NZ_CP012069.2|WP_050343758.1|962975_964592_+|peptide-chain-release-factor-3	unknown	unknown	gnl|CDD|179105
NZ_CP012069.2|WP_172674437.1|982173_982413_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343770.1|970928_971585_-|inosine-monophosphate-cyclohydrolase	unknown	unknown	gnl|CDD|377923
NZ_CP012069.2|WP_050343774.1|975287_976544_+|aspartate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|235056
NZ_CP012069.2|WP_050343764.1|967955_968222_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343783.1|981437_981929_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051390.1|967417_967600_-|TetR-family-transcriptional-regulator	unknown	unknown	unknown
NZ_CP012069.2|WP_050343776.1|976712_978446_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343766.1|968326_969121_-|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl|CDD|273806
NZ_CP012069.2|WP_050343780.1|979243_979693_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083443800.1|978476_979247_+|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl|CDD|379084
NZ_CP012069.2|WP_050343760.1|965411_966173_+|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NZ_CP012069.2|WP_050343781.1|979703_981278_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|177094

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050343768.1|969725_970904_-|phosphoribosylaminoimidazolecarboxamide-formyltransferase	gnl|CDD|180841	PRK07106, PRK07106, phosphoribosylaminoimidazolecarboxamide formyltransferase.	0
NZ_CP012069.2|WP_050344763.1|974392_975286_+|acetylglutamate-kinase	gnl|CDD|239783	cd04250, AAK_NAGK-C, AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the non-acetylated, cyclic route of ornithine biosynthesis. In this pathway, glutamate is first N-acetylated and then phosphorylated by NAGK to give phosphoryl NAG, which is converted to NAG-ornithine. There are two variants of this pathway. In one, typified by the pathway in Thermotoga maritima and Pseudomonas aeruginosa, the acetyl group is recycled by reversible transacetylation from acetylornithine to glutamate. The phosphorylation of NAG by NAGK is feedback inhibited by arginine. In photosynthetic organisms, NAGK is the target of the nitrogen-signaling protein PII. Hexameric formation of NAGK domains appears to be essential to both arginine inhibition and NAGK-PII complex formation. NAGK-C are members of the Amino Acid Kinase Superfamily (AAK).	3.63739e-135
NZ_CP012069.2|WP_050343762.1|966255_967035_-|MerR-family-transcriptional-regulator	gnl|CDD|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	7.75604e-29
NZ_CP012069.2|WP_050344761.1|964886_965408_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.0189e-16
NZ_CP012069.2|WP_050343787.1|983106_983955_+|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	gnl|CDD|197918	smart00850, LytTR, LytTr DNA-binding domain. This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.	1.59865e-15
NZ_CP012069.2|WP_083444084.1|973053_974340_+|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ	gnl|CDD|376687	pfam01960, ArgJ, ArgJ family. Members of the ArgJ family catalyze the first EC:2.3.1.1 and fifth steps EC:2.3.1.35 in arginine biosynthesis.	0
NZ_CP012069.2|WP_050343770.1|970928_971585_-|inosine-monophosphate-cyclohydrolase	gnl|CDD|377923	pfam07826, IMP_cyclohyd, IMP cyclohydrolase-like protein. This enzyme may catalyze the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to inosine monophosphate (IMP), a reaction which is important in de novo purine biosynthesis in archaeal species. This single domain protein is arranged to form an overall fold that consists of a four-layered alpha-beta-beta-alpha core structure. The two antiparallel beta-sheets pack against each other and are covered by alpha-helices on one face of the molecule. The protein is structurally similar to members of the N-terminal nucleophile (NTN) hydrolase superfamily. A deep pocket was in fact found on the surface of IMP cyclohydrolase in a position equivalent to that of active sites of NTN-hydrolases, but an N-terminal nucleophile could not be found. Therefore, it is thought that this enzyme is structurally but not functionally similar to members of the NTN-hydrolase family.	2.03884e-57
NZ_CP012069.2|WP_050343774.1|975287_976544_+|aspartate-aminotransferase-family-protein	gnl|CDD|235056	PRK02627, PRK02627, acetylornithine aminotransferase; Provisional.	0
NZ_CP012069.2|WP_050343781.1|979703_981278_+|AAA-family-ATPase	gnl|CDD|177094	CHL00195, ycf46, Ycf46; Provisional.	3.27388e-84
NZ_CP012069.2|WP_050343766.1|968326_969121_-|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl|CDD|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	1.78405e-14
NZ_CP012069.2|WP_050343758.1|962975_964592_+|peptide-chain-release-factor-3	gnl|CDD|179105	PRK00741, prfC, peptide chain release factor 3; Provisional.	0
NZ_CP012069.2|WP_083443800.1|978476_979247_+|zinc-ribbon-domain-containing-protein	gnl|CDD|379084	pfam13240, zinc_ribbon_2, zinc-ribbon domain. This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.	0.000133997
NZ_CP012069.2|WP_050343760.1|965411_966173_+|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	5.26994e-10

Protein sequences

>NZ_CP012069.2|WP_172674436.1|971584_971761_-|hypothetical-protein
MIEYLWAAGDVVRHQLGGARDAAHRASGDLFRRDVGLLSQLRASGRQLLRRGRTRGDL
>NZ_CP012069.2|WP_050343770.1|970928_971585_-|inosine-monophosphate-cyclohydrolase
MQDLCELLRNNPYPGRGIVVGKDWGGRHCAYYWIMGRSPNSRNRVFSLTADGIRTEAHDPALLKDASLIIYHPVRRMGDDLVVTNGDQTDTIVDTGDFFAACMAREFEPDDPNFTPRISAILHAGGSFELSILKRQAGASGRCQREFFCYEGADEGTGYLISTYQGDGDPLPSFVGEPVEVSLPTANELWVALNADNKVSLYANVGGTVKLYNKNLGD
>NZ_CP012069.2|WP_050343768.1|969725_970904_-|phosphoribosylaminoimidazolecarboxamide-formyltransferase
MNELELKYGTNPNQRPSRVFMRDGSDLPMTVLSGRPGYVNLLDALNSWQLVRELREATGQSAAASFKHVSPAGAAVGRPLSDVDRQMYFVDDEGELSPIACAYIRARGADRVSSYGDWAALSDCCDERTARYLKHEVSDGIIAPGYSDGALEILRSKKGGRYNVVLIDPDYRCAPIEQRDVFGVTFEQGHNDLAIDRSLLKDVVTANRDLPDTALTDMLISLVTLKYTQSNSVCYVRDGQAIGIGAGQQSRVHCTRLAGSKADAWFLRRHPKVLGLKFAEGIRRAERDNVIDVYISDEQDEVLAEGAWKQWFAERPEPLTREERTEWIAAQDGVTLGSDAFFPFGDNVERAHKSGVSYIVEPGGSIRDDDVIAAADRYGIAMCFTGTRLFHH
>NZ_CP012069.2|WP_050343766.1|968326_969121_-|Rpn-family-recombination-promoting-nuclease/putative-transposase
MARAVRDVGKLRPIDDLMFRVMAQSKAFCGELLRVLLQDPGLEVVECKPQSAVTNTRGRSAVLDALCELSDGRLVDVEVQRADKGDLQRRARYYASLVTADRTRPGTPFGDVPDVCVVLVCEFDPLRGGRPLYHVDRVVRETGESAENGLEELYVNALARDGSEVSALMRVLTEAEAYDEERFPETSRMKRRLRETEEGRKDMGSVIEEIRAECIAEGEERGKLEGKLETLVRLVRDGLVSVQDAATSVGVDADEIRRALAAEG
>NZ_CP012069.2|WP_050343764.1|967955_968222_-|hypothetical-protein
MRVLTETEAYEEERFPETSRMKRRLRETEEGREDMGSVIEEIRAEGIAEGKLETLVRLVRDGLVSVQDAATSVGVDADEIRRALAAEG
>NZ_CP012069.2|WP_157051390.1|967417_967600_-|TetR-family-transcriptional-regulator
MPGASLRSICAAAHVTTDALYFLFAGKGELFERALGPSFDQVALVLAHSLPARADQPHAG
>NZ_CP012069.2|WP_050343762.1|966255_967035_-|MerR-family-transcriptional-regulator
MDESKPAGRHYSVGQLAQMAGVSARTLRHYEDMGLLEPARAENGYRTYGPRDARRLSQILAMRACNLPLTTIRHLLRDSQASLRDTLESHLRTLRAQKKSLSDAMARTKAAIATIEGIENMDNEKRFEAIKAQGLKEFEDTYGTEARRRYGDEAIDAANERIMSLTRDEWDAKDLLEEAIKVQLRLAMASGDPTGDQAAELAHMHERWMRIHWGKSYDRKVHLALVRGYLGDPRFKNYYDTAAGNGGAEFLVKTMEANL
>NZ_CP012069.2|WP_050343760.1|965411_966173_+|CPBP-family-intramembrane-metalloprotease
MDEAMTDGRHIARYLIIAFAMTWTCWMARAALCASGVATVDSPAVLPLFLIGGFGPTVAALVVRPDARSLHGFARFVCGGSRTSIGWLFLLVVLGALSIAGNSSGLNAAIPAFAIPVIFLVTTLIGGGNEELGWRGVLQPELEGRLPYPVATLVTGVIWSVWHVPFWLTPGDSHLSFPFLLFALQAVLLSFWLAGLRRRGGSVLWCAVLHGAMNTLMSAFVLQLNAPFVIGMLAITALSIWMGMAAQRDDRRA
>NZ_CP012069.2|WP_050344761.1|964886_965408_+|helix-turn-helix-transcriptional-regulator
MKIETAKRLYEYRRASGLSQEQVAAKIGVSRQAVSKWECAESSPDTDNLIALALLYGVTVDELLFADPERAIVATLERETDADDPEEGAESASVAEGAPAEAGEESAWQSPEHPEQDYVNISFSQGVHVRDSKGGEEVHVGWDGIHVDSDKEHVHLNFGGLAKMIREFRKDQE
>NZ_CP012069.2|WP_050343758.1|962975_964592_+|peptide-chain-release-factor-3
MPSLSDQIASRRTFAIISHPDAGKTTLTEKLLLYTGSIQTAGSVKGKASARHAVSDWMDIEKERGISVTSSVLQFTYDGYCVNILDTPGHQDFSEDTYRTLMAADAAVMVIDGAKGVEAQTKKLFKVCTLRHIPIFTFVNKLDRDARDPFDLMEEIETVLGIGTYPMNWPIGSGRGFRGVFDRAARRVLAFEGDGHANATKRVDEVEAELGDPALDELIGEENHRNLGDDIELLDGADNEFDLEAVHTGKLTPVFFGSALTNFGVGPFLRDFLCLAPAPLAYMDRLTGEKVDPSRNDFSGFVFKIQANMDKNHRDRIAFVRICSGKFERGMDAQHVQGKRRIKLACGTAMMADDRATVDEAYAGDVVGLFDPGLFSIGDTVCAGRRQVEYPSIPTFAPEHFARITQVDTLKRKQFIKGMEELAQEGAVQIFRELGTGMESVIVGVVGVLQLDVLERRLRSEYGVEVMRQPLPYSEIRWIVNSPDDIDVARLNLSRDTCRVEDMRGGRLLLFTNEWNVDWAIERNPDLRLSEFGNVSLS
>NZ_CP012069.2|WP_083444084.1|973053_974340_+|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ
MSGFEPLRVPERDGAAEGFGFVPCEGGVCAARGIRATGVSAGFRHNPDRRDLALVVADRTCVCAGTFTKNRFCAAPVQVSRPRAASGHARAVVLNSGNANAATGEQGLEVARASARIVADALGCAAEEVLVASTGVIGVPLGLECFEMGVPACVGQLERSVAAAHHAARAVMTTDTHSKQAAYVGSLPAPGGGTVEVHVGGFAKGSGMIQPDMATMLSVLSTDAPLTPKAARVALGRAVSQSFNKVTVDSDTSTNDCCILFATGEAELEAIDEDSAAFPAICAALRATCEALARQIAADGEGSTRLVTVDVMGAATEADADAVARAVANSPLVKTAVFGHDANWGRVASAAGKCGVAFDQRKVDIDLLGVPVCRSGLAVAMDEDDMLKRFKESEVPIAIDLGMGSCSTRVWTCDLTHDYVTINGDYRT
>NZ_CP012069.2|WP_050344763.1|974392_975286_+|acetylglutamate-kinase
MRRRRPSDASQGKAEVLVEALPWINEWAGSTFVVKYGGSAMEDATLRAKVIEDVLLLKLMGVHVVLVHGGGKDISSLSDRLNLSVRFKDGLRVTDEDTMEVVQMVLVGKVNAELVQAINGYGNHAVGISGADGRTLRACQLDPELGRVGRVTEVNPDLALKVLDDGYIPVIAGVGFGEDGGPYNVNADFTASHIAQALGADKLFFLTDVDGLYADFDDKDSLIAGMGVGEARHLIDAGTLSKGMIPKVRSAIEAIEAGVGQVTILNGTVEHALLVETFTDEGIGTEISNDSRNPKEA
>NZ_CP012069.2|WP_050343774.1|975287_976544_+|aspartate-aminotransferase-family-protein
MYEFDTHADFIAGDERYLMHSYARLPVKFVRGSGCVLTDSEGRDYLDFLGGIGVVCLGHCHPRLVDALKGQAERLWQVGNYFHVENRSELAAALSRLLGATTDEEGHVTGSTGQTWRTFFANSGAEANEGAIKLARRWGERRLGGATGIVTAKRSFHGRTLATLAATGQDVFHKSFAPMPAGFMSAELNDLAALEEAIARPEASCGPVCAIMLECVQGEGGVWPADPEYLQGAARLCEERGLVLIVDEVQTGVFRCGAPFSYQLAGIVPDIVSMAKGIAGGFPMGAFSAHGEVADLLGPGDHGSTFGGNPLACAVGRATMETLVAEGIGEHVIEVGAQLAERLAALPHVTEVRGRGLMRGAQLDAPMARSLVEQGLRAGLVLNCVGDSTLRFLPPLVVTAGQVDAMAERLAKLMGQVA
>NZ_CP012069.2|WP_050343776.1|976712_978446_+|hypothetical-protein
MADRIIQTADLTTIENNLTSMRRAIEQVDDSVANVNRQMNGVEVRLDALASDFRDYVNNEMRRWELEHATTKLNNIRQQLAVKFGHYSEVRRTTTGILQATDLGIVRNATITKASEDLMLKCPEYWLAPCLVALAAWINDEKDIAKKALKEAIHRNDEKASLLFGLICRRANRQGPALEWVRRYLANQDPEGLGREAIIILDAYATGLFSADSEGAIAGQLNDWCDLLASRPGFLEEQTSRWKTALKDKRKPVDPTKYPYLRKYSHTWPILEDILEGAMAHQYILAYFKDIFAQQPSQDVVRKQLDDILTTLVSEFDDEELPLKREERLCELIIEHEGDTQEAQILADHEKTSMEEQRDFTQLLTDAAMYPDISRSSVSSQQFAVAYSREWICNGYNDMVAENRMKIPNDIEINIDSFNAVTSAGTDEENLVKAFDELVESERSAELDKTVLTPFEQNCHYAGIACIAFGLIALAAKLTFFGVLLCIAGIALVYKHYSQEKNINSHRDVINSNYDTKKENGTKLLKATIAEIVDFRIEFSQYDAGSQEVLDMLNELSPDEYVRTLTGVTRHIVSATH
>NZ_CP012069.2|WP_083443800.1|978476_979247_+|zinc-ribbon-domain-containing-protein
MCGKKNRDSSNFCARCGASLKRLGVPASRADAAPERGGSVEAPAEQAFANVVPEVDSVPSKEVGEVAERQQDILVDAAPGGNDAPFEEVAEVAESQQEVIADVTPEGGGSVEVPAGQAFANVAPEGDDIPAKPEQATPEPNHIAMAEETGPSLPFEAISEHTEDAFAAVADEANDMDTLAPKGTAGDPSPADNGVGRMFASVDVGTFVSPRPVNNDVGKGNESVMEAYPTFAQGLPDWDLTPPSSMVIRHVRMAQK
>NZ_CP012069.2|WP_050343780.1|979243_979693_+|hypothetical-protein
MRSPHTYAEWVEVIDIFGNRLDDDGAISAMRSGTLDWQAGVSDRFLQKLIGAVNKRMNAAVDAFQKRQRRSVADERSITEALLAFRREFITLMNAVDIPAMPEKYREECRSLIRGQADANQSSLEDSAPRVDRSGKLLSIIHKTPVNKF
>NZ_CP012069.2|WP_050343781.1|979703_981278_+|AAA-family-ATPase
MSSKHETRDLLVRYAKARIPLITIKTDERRRAIEILTEVAEELGVKVYCHTKSKGIYDVTSMQTVCDGESVYEAFDFMREQMKKRSQLTFALSETGDISTETGDAQDLYDLVQSAVDASTTIIVITNKDVWGQLQQTGLVVVLDRPNEEEAYAVIRGLIDQYRGSIPIEWTDEEVREAASALAGVSQIEIENTIASLIANGHIGEDDLVEIRGSKDKLFSNISGLEKIQTSKSDAEVGGLAALQEWCKEKKELLTPEKRDALLKMGLKPPRGILLVGVPGCGKSLSAKSIASSWKLPLYRLDFATVQGSYVGQTERQLKEAFTMAEAVSPCVLWIDEIEKGLSGATASAGDGGVSTRMVGQFLFWLQECMKMVFVIATANNVSQLPPELLRRGRFDEIFFVDLPTTEERQSIMSLYMKKYLSLNFAGPLADELVELTEGFSGADLESTIRDLAYRKVANPQLSITADIIRKAFNNVVPLSQTSPEQIESIQNWGRERAVPASGKPIGSHPLQRSEGPRVREVLI
>NZ_CP012069.2|WP_050343783.1|981437_981929_+|hypothetical-protein
MPRQLLNVHANSRRQQQLDVQSSSKKAQQKVNPVTFERALRKHRSKRYIELMKKLDAGGHVTNQQQVNYLIAALRNELGELDESLSDSLRGIVSKCYLGDPYEVHTLDVAQCIIDHYARGERLPGTLEKVRGIAMLGGYDFIEVYDGYFCAVSDSGSVSVIRG
>NZ_CP012069.2|WP_172674437.1|982173_982413_-|hypothetical-protein
MREASDAGKDDAKERLHALVESALKVSGITGETSFCGELGVDSMQLVVLLLACYWRSRENSRSPFPTVASWLPVQPLAR
>NZ_CP012069.2|WP_050343787.1|983106_983955_+|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein
MDLHIAVFDADANQSQNLVGLIGKLGLTWYGSPGHLVPTVVERSAYPDQGIDDLDVFVLSGVDSLVSHVPDVLFIASKLGGVDDAIRVVSGFLSDRHTTQIIFIVPSDVSVAHGHTVQHVGFLVCPISLDKLELALNRAVLTLFLERCQLGFDCPLCLRGTKATFYVLVSDIRYVESRGRTLHIHLRPHSKAMKKDDVSDGMASASGILDEVIPVTMSLKKFQTFVPDTFIRCHNSFLVNLSCVFRLSRDTITLRDGTCIPVSERKRQHVQQQLCRYGRVVA

Crispr_ID: NZ_CP012069_15

• CRISPR_ID: NZ_CP012069_15
• CRISPR_location: 1031598-1031729
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_15

Consensus_repeat	Method
GATCGGCGAAACTGGCCTCTCGGCGCCGTTTTGGGGCA	CRISPRCasFinder

spacers of NZ_CP012069_15

>15.1|1031636|56|NZ_CP012069|CRISPRCasFinder
CTTGTGTACACTGTTGCGCCGTTGTGGACAGGTGAGGCAACGCAAGAGTGTACACA

CRISPR arrays and Neighbor proteins around NZ_CP012069_15

CRISPR arrays

The CRISPR arrays of NZ_CP012069_15

>merge|NZ_CP012069|15|1031598-1031729|CRISPRCasFinder
GATCGGCGAAACTGGCCTCTCGGCGCCGTTTTGGGGCACTTGTGTACACTGTTGCGCCGTTGTGGACAGGTGAGGCAACGCAAGAGTGTACACAGATCGGCGAAACTGGCCTCTCGGCGCTGTTTTGGGGCA

>NZ_CP012069|15|12|1031598-1031729|CRISPRCasFinder
GATCGGCGAAACTGGCCTCTCGGCGCCGTTTTGGGGCA	CTTGTGTACACTGTTGCGCCGTTGTGGACAGGTGAGGCAACGCAAGAGTGTACACA
GATCGGCGAAACTGGCCTCTCGGCGCTGTTTTGGGGCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050343862.1|1040703_1041876_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|223673
NZ_CP012069.2|WP_062393174.1|1043436_1043955_-|hypothetical-protein	unknown	unknown	gnl|CDD|224336
NZ_CP012069.2|WP_050343870.1|1044885_1045659_-|YdcF-family-protein	unknown	unknown	gnl|CDD|99750
NZ_CP012069.2|WP_050343844.1|1019757_1020087_+|hypothetical-protein	unknown	unknown	gnl|CDD|224919
NZ_CP012069.2|WP_050343855.1|1027355_1028591_+|hypothetical-protein	unknown	unknown	gnl|CDD|227283
NZ_CP012069.2|WP_157051399.1|1033522_1039405_+|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NZ_CP012069.2|WP_172674523.1|1045694_1046882_-|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl|CDD|236226
NZ_CP012069.2|WP_050343874.1|1047154_1047997_+|hypothetical-protein	unknown	unknown	gnl|CDD|273344
NZ_CP012069.2|WP_083444085.1|1041899_1042535_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224041
NZ_CP012069.2|WP_050343854.1|1026713_1027148_+|peptide-deformylase	unknown	unknown	gnl|CDD|181704
NZ_CP012069.2|WP_172674442.1|1039584_1040685_+|Tat-pathway-signal-sequence	unknown	unknown	gnl|CDD|223787
NZ_CP012069.2|WP_050343859.1|1029682_1030990_+|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|234685
NZ_CP012069.2|WP_157051397.1|1020311_1020488_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051398.1|1032500_1033160_+|hypothetical-protein	unknown	unknown	gnl|CDD|237927
NZ_CP012069.2|WP_050343857.1|1028712_1029327_-|hypothetical-protein	unknown	unknown	gnl|CDD|224651
NZ_CP012069.2|WP_050343864.1|1042538_1043444_-|putative-ABC-transporter-permease	unknown	unknown	gnl|CDD|377672
NZ_CP012069.2|WP_050343851.1|1023112_1024720_+|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|225420
NZ_CP012069.2|WP_050343846.1|1020586_1021186_+|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl|CDD|379128
NZ_CP012069.2|WP_172674441.1|1022308_1022704_+|hypothetical-protein	unknown	unknown	gnl|CDD|273806
NZ_CP012069.2|WP_050340811.1|1024843_1025917_+|IS5-family-transposase	unknown	unknown	gnl|CDD|376573

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050343862.1|1040703_1041876_+|ABC-transporter-permease	gnl|CDD|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	1.55658e-43
NZ_CP012069.2|WP_062393174.1|1043436_1043955_-|hypothetical-protein	gnl|CDD|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	7.86551e-05
NZ_CP012069.2|WP_050343870.1|1044885_1045659_-|YdcF-family-protein	gnl|CDD|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	6.4121e-39
NZ_CP012069.2|WP_050343844.1|1019757_1020087_+|hypothetical-protein	gnl|CDD|224919	COG2008, GLY1, Threonine aldolase [Amino acid transport and metabolism].	2.97566e-07
NZ_CP012069.2|WP_050343855.1|1027355_1028591_+|hypothetical-protein	gnl|CDD|227283	COG4947, COG4947, Uncharacterized protein conserved in bacteria [Function unknown].	6.09814e-38
NZ_CP012069.2|WP_157051399.1|1033522_1039405_+|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	3.31607e-08
NZ_CP012069.2|WP_172674523.1|1045694_1046882_-|NADP-dependent-isocitrate-dehydrogenase	gnl|CDD|236226	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase.	0
NZ_CP012069.2|WP_050343874.1|1047154_1047997_+|hypothetical-protein	gnl|CDD|273344	TIGR00927, retinal_rod, K+-dependent Na+/Ca+ exchanger. [Transport and binding proteins, Cations and iron carrying compounds].	0.000160558
NZ_CP012069.2|WP_083444085.1|1041899_1042535_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	5.42115e-44
NZ_CP012069.2|WP_050343854.1|1026713_1027148_+|peptide-deformylase	gnl|CDD|181704	PRK09218, PRK09218, peptide deformylase; Validated.	2.02945e-30
NZ_CP012069.2|WP_172674442.1|1039584_1040685_+|Tat-pathway-signal-sequence	gnl|CDD|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	1.55711e-06
NZ_CP012069.2|WP_050343859.1|1029682_1030990_+|glutamate-5-semialdehyde-dehydrogenase	gnl|CDD|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	0
NZ_CP012069.2|WP_157051398.1|1032500_1033160_+|hypothetical-protein	gnl|CDD|237927	PRK15219, PRK15219, carbonic anhydrase; Provisional.	0.00402933
NZ_CP012069.2|WP_050343857.1|1028712_1029327_-|hypothetical-protein	gnl|CDD|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	0.000116065
NZ_CP012069.2|WP_050343864.1|1042538_1043444_-|putative-ABC-transporter-permease	gnl|CDD|377672	pfam06541, ABC_trans_CmpB, Putative ABC-transporter type IV. CmpB is a family of membrane proteins that are likely to be part of a two-component type IV ABC-transporter system. Families can transport multiple drugs including ethidium and fluoroquinolones. UniProtKB:Q83XH0 is a member of TCDB family 3.A.1.121.4.	1.58888e-55
NZ_CP012069.2|WP_050343851.1|1023112_1024720_+|putative-DNA-binding-domain-containing-protein	gnl|CDD|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	1.82521e-32
NZ_CP012069.2|WP_050343846.1|1020586_1021186_+|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl|CDD|379128	pfam13338, AbiEi_4, Transcriptional regulator, AbiEi antitoxin. AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	1.48233e-05
NZ_CP012069.2|WP_172674441.1|1022308_1022704_+|hypothetical-protein	gnl|CDD|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	0.00188697
NZ_CP012069.2|WP_050340811.1|1024843_1025917_+|IS5-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.72577e-22

Protein sequences

>NZ_CP012069.2|WP_050343859.1|1029682_1030990_+|glutamate-5-semialdehyde-dehydrogenase
MAGGTGSSNTTIRDTVQRMRIESPAMASTPLSQRDAALVRVKEALLSHQDDIFSANTEDLARAKRDGAAPAVVKRLLFDEHKLKDVCAGIDSLLGLEDPVGRVLLRRELDEGLELTRVSCPIGVIGVIFEARPDALVQISALCLKSGNMAMLKGGSETAESNRTIFSLVHEAAVAAGLPSTCLALAESHAQIDELLGCFGLVDLLIPRGSNAFVRHIMDNTKIPVMGHSDGVCHIYVDVSADLPSAISICVDAKCQYTAACNAVEALLVHRDVAGDFLPLLAGAYAAAGVEIRGDERVRALIDCKSATQEDWGAEYLSPTIFVRVVDSLDEAIDHINRYGSHHTDAILTEDAAAAERFMRLVDSAGVYQNVSTRFADGFRYGFGAEVGISTGKLHARGPVGLDGLVTYKYQLRGHGQIVGDYAEGRSQFHFCDLT
>NZ_CP012069.2|WP_050343857.1|1028712_1029327_-|hypothetical-protein
MSRVSYDILQPGALSDEERETLRRHYLVYAKAELGQGRKLRADLDHIYATVDELASSGKLDRLVSTMHTSAHVVLFSTEASRISLEEFQLAMLSEGRPVRMVGEDSSDINGIGALSEGDLLIVVTTSNGFAHRQRANICRSEAHKVIITAHDDPELHAEFDEVLSIGEGASEGSPLHRIYATFGVTYFFDRLFTLYANIYDPEL
>NZ_CP012069.2|WP_050343855.1|1027355_1028591_+|hypothetical-protein
MEVKNYTLHGDKANKDFDLVVYGSTGRPAIAFPEGDSSCLSWENNGMVDAVADLVDAGKVQLFCVDTSDSESWHAHGALREYRLENLEGFFAFVEGELATFIKKASGSKEPPLVLGAGMGALNATIAMLRRPKDYSGLLALSGTYDVHQLIEGDLDEPWRAFSPFDLLADLTSRKAEATLLRERQLAFVCGQHGSETGADTQRQLDAAMAERDVPATFEYWGFDVSHDWYWWHEELRQFLPCLLVEGGLKRRIQDALVARAQGEASRAKEVTDQREQELADAKNALSLAKTAVKESEGRQRDEEAHIREQRDSSAKLARLAADAWAERDRIAALLSEAIQKGEAAQAQADAAAKGLADAEWIAGEARAAAQEAVAQREAASRRVKDCEAALEEARAAQASADDALERAKRG
>NZ_CP012069.2|WP_050343854.1|1026713_1027148_+|peptide-deformylase
MIKELVKDKEILSARCERATPEDAPIAQDLIDTLASIEDGACLAANQIGITKQIGVYLDKDKKDEEKRPHVLYNPHLMMGLGAKRGEETCLSHEENSTVTRYTKVKVSFDELVDGEFVERRHDFTGWTAQMVQHIIDHCQGKLV
>NZ_CP012069.2|WP_050340811.1|1024843_1025917_+|IS5-family-transposase
MAQLTFSDVEMGMGRKRETRRSRFLDRLSKSCPWDAWLALVREARGADAGARGAGPAMGRPRVDDLVLLRMYMVQVCFGLSDRECEDQVWDSATMRSFVGVAPFEVPDATTLCKFRHLLERCGVGEAMVSSAFGSAADGGLAVSRGTIVDATFIESPSSTRNADGARDPDAHQAKKGQNWHFGYKLGVGVDAETGVPHSVRMDAANVHDLDQVPDLVREGDERVWADAGYVGVGRRPEVAGDPSLSGVEWIVAKRRSQVGEDDLVAEAAKSAARSVVEHVFHWVKDIFGLRKTRYKGLAKVSNQAFAAVAAAGCMIARRGRRLCGPPLALSAERIALQRERLEERRRRAEGGAPAAA
>NZ_CP012069.2|WP_050343851.1|1023112_1024720_+|putative-DNA-binding-domain-containing-protein
MLSVDSLKGHREGNRLEFKRAEGGLPHSFWETYSSFANTDGGIVVLGAVEGTDGLPVPSGIGDVGSLLKDLWDGLNNSQRASANILVDSDVTVEDWEGREVVLVHVPRADRRMRPVYVGNNPRTGTYRRSGEGDYHVAEETYRSMVRDSAPESVDRTVLDAFSLDDLHSETMRGYRNLFRSTRPGHPWTGLSDEAFLTRIGAIARSGDDHALHPTRAGLLMFGEAWRIVSEFPRYLLDCRQELADNNRWNNRLVSDSGDWSGNVLDFWGRASRMLTEGLPVPFRLGPDMRRIDDTPQHRAVREALTNALVHADYSGRTGVVLVRKPDRVIASNPGTLRIALDEVEAGGVSDPRNETMLFMFSLINIGERAGSGFDVLREGARSAGKPEPLLEELYEPDRVRLTLQIETSGLVGFHLPGMGGEGAPLVTAVKPPSGQSVIGADGANAGAVVGANGANGADSGANAGGGTGGAGGPLSDAGARVLDALRANPRASAVALGKELGMTRRQIQRVQGNLKGAGILERVGGTRGYWRIKA
>NZ_CP012069.2|WP_172674441.1|1022308_1022704_+|hypothetical-protein
MRETGGIAGSGLREVYVSALARDGSDVAALMGAFEEAEAYDETRFPATSGEKRRLRHTKEGRGTMSRVVEEIRAVGRREGIEMGRAEGRIKGKAEGRAEALGRLVRDGLVDARAAAASLGLDPEEVERMLA
>NZ_CP012069.2|WP_050343846.1|1020586_1021186_+|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MAGVDISEQINGLGGIATSSELKSAGFSAGAIAYALETGSIDRLTRGVYCAPDVFEDDFAIISYRWRKCVFSHASALYLLGLSDRLPSEQHVTVPRGYNPKGLKNAYPGIGMHWVSSELYPLGETTVKTPVGNTVRCYDAERSIADLIRQRKRDGANAQLVRDSVTGYFKRADKDLPKLAEMCEALGVRDELQVYLEVM
>NZ_CP012069.2|WP_157051397.1|1020311_1020488_+|hypothetical-protein
MPYVKCISGHTSARGVQRYLEKDGRALATDFLNLDAPVKGVRDGLEDYAAFEWWRGDM
>NZ_CP012069.2|WP_050343844.1|1019757_1020087_+|hypothetical-protein
MELEALSKICHEHGMSLSVDGARLAYALLAKGRVLGLSSRRSSRMVSMSTSGFGCTEAGKVAFFGDVPRPSRDGLREPGPSGVYHSWGAWSSLGYLCFFRAFAQWAQYG
>NZ_CP012069.2|WP_157051398.1|1032500_1033160_+|hypothetical-protein
MSEQTRLNTSANMDEPTNLSRRDFLKGAVGVTLAIVAVSAGLSLPGAGEALGTAPQKAYAATATSAGTYTITANLYVDKKDTPIGKYAYVTNSGNPPFHKPTSPVSDNAKLQVTESGKKLLTVPIVNNTFGVLSIATTSTNNSVKVIDKSMTTWRAPWPWSTPYKERISSITFDVTNFSGGNSIADFTPCAEYATFPLYKGDKHWDLHLIVNFNSAKSV
>NZ_CP012069.2|WP_157051399.1|1033522_1039405_+|hypothetical-protein
MGTSSSSRDGATNDPLGESVPEESYADALERSVVEGTDLLSAALSSAPHDANNPHTKVEVGKYAPGTYTVTANLFIPASRNPFNGAIQTYMTNPENPLGIVEPDNGDPGAVTGGVPTFHVEKNATLTVGEDDSLTLTVPIRNPVFTLQGIGSGQGAELVSAHTRAGEYGPRDASGKVTIVGHTSRVDSITFRLSDSGKTTDGSDGYTIQRCSEYPTILNQNWHADLDLTVDLSNVPASQKYVSDPTVAQDLTYNGHEQQGVTFETDKCDVISGAATATNAGDYSLTLKPKNGLTWLDGTTDARSLDWKIAEAQGVKEYETVAPCPEDASKTIAAQPSADAVNAGFPYEGLIGSHAPESLGITSQTSDAWNPGTFGHAQLMSEPRVLEPGTYTVTANISMMTPLGFPGYTTNPFNPEGIGGKGGIPNTPVSNNATLTVGADGSRMLSLNLVNPVFTVQNAESSKGVTVEATDRVPIEQKGDDEEYNKAVAADGITSRIAHMTLRLNDWSGSYHFDNWKVYATTLRTFFPNNKYPQIKSLDLSVDISHAQKQVEGDYLKTFTDNATGVSVTVSAEKGTSVIPQLEKASLQVEKIESGMEHDGVKQALTQLYASAPGFSLYRVLLIADGKPISLDDKTSAEVSIPAARPNAAVYSFRAASLSAVESRMSSGKISFKPSQLGSFVVVDSQGVAKFSWSHTVRDASTGASMTYSTDASVEDTLFESAYGPGKGLEALEWYASYMDASGVSSSQAPSSFGEKALSAAKESGSGGWTIAGAYAMGISYSMDGSGVPNNLFDSLSLGYTFTAGINPLSAIVPVASGNASVYAVYGTVGAGATGVKKLSAQITDGYAKVSLNDSDAQIPGLSSMLFHAAAGVGDYTGAPQTAETQIAYLMVVEPSTQKIAEPSVARGLVYSGREQVGVPAGEGYDVSGGAAVAAGDYEATATPRDGYAWADGSVAPRAYRWSIARAPLTAAYAGEEVAEGGTPALRVSVSGFVGGEGARTAAGYVAPTVAAPSPLRAGSYELAPAGGAADNYAFSYVAGTLTVLPRDTPRPDPGPAPRPGELAPGTYALTANLAMPGQYNPVISGLTVYANSPNNPFGPTIDENDPAEVRNEIPSSPLSMNARLVVSADGARTLVLPVRNPIFTTQELGTCEGLADVRTERVRPTAAGGDWSGSYNRRPDRIHMMSARLPLGPASGTAEFAFRGSVLYAVPLDRELRPSGDVALRLTVDYSSLRRDSDSTELPAFAKGDAPRPDPKPGPRSAAEPSVARGLVYSGREQVGVPAGEGYDVSGGAAVAAGDYEATATPRDGYAWADGSVAPRAYRWSIARAPLTAAYAGEEVAEGGTPALRVSVSGFVGGEGARTAAGYVAPTVAAPSPLRAGSYELAPAGGAADNYAFSYVAGTLTVLPRDTPRPDPGPAPRPGELAPGTYALTANLAMPGQYNPVISGLTVYANSPNNPFGPTIDENDPAEVRNEIPSSPLSMNARLVVSADGARTLVLPVRNPIFTTQELGTCEGLADVRTERVRPTAAGGDWSGSYNRRPDRIHMMSARLPLGPASGTAEFAFRGSVLYAVPLDRELRPSGDVALRLTVDYSSLRRDSDSTELPAFAKGDAPRPDPKPGPDNPNKPNNPNSPTPNPNNPNNPTPSPNNPSNPNPSPNNPSNPIPVPNSGKGSGGGISPKDSGDAIRTSNGHLAAGTYTVSANIWVNKATSGLPLQPHFTSAAFPPMNPVSKNATLRVESDGHAYVTVPIVIQSRVMHVLSLTGLDIVRQSYSGEGLSSITVDLGVLRNTDTITKNVTARIRLGSLAKTIIGGNENRTWACTFQVVFNGTSASGGGTIPKAAQDIINAQGKDGRAANSDERARSAADAAMAALDADDGGAAGEDAPAAGSSSAQTTRGRSKGTAEQAAQAAEQLAQGNAGLVAGMVALGIVALGAVAYALHLRRRLKGMGSPPPSGEA
>NZ_CP012069.2|WP_172674442.1|1039584_1040685_+|Tat-pathway-signal-sequence
MRRVFTRRAFVRLGSAVAASLGLAMAGCSAPQGAQPQDRSVSAGFTTQPEDRDPMGSAESTTVCVGLIMGPPSMGLTQFLLAARNGRTTNDFQFTFNGVDYIGLSAALNNGDYDVATLPSNIGPILYNNKELHNQYEVISINNLGVLYVMTTDESIRALSDLAGRHVYSYGEGGTPEYTIEALLRKAKLADSFQLEFKSSPFEVLNLMQSEKNCVAILPQPFVSLSKLMVDPLYTPVNITEEWDKAFSDTGSQAVTTTTIVNKAFLEAHEQAIIEYLRMAGKSVDWSLSHMEEASALQEELGTFLNNAVALDAMPQISMVNLTGVKMRTALSGFIDELYAANPDSVGGAIPAEDFYYLPPAGALGS
>NZ_CP012069.2|WP_050343862.1|1040703_1041876_+|ABC-transporter-permease
MGQRGPLALLREALRHSSDVQGQASLGSAHASRVQLAQMAGVLGLPEERVAQMAALVRDSDIDDAQLGSLMRMVTSKGLSCEQVMALLLSLGVGRVRAVRILQAQGIMGDKEAQRILNEERRAAQEQAADDRRGAWRGRLAKGAIIAFWLVVWQLVDTLVDNRLILTGPVRTLQALGEQATKAGFWVICGASFGRIALGFLLSFSVGICLALLSYRVHLVRAFVEPIVSLLRTIPVVTFIIMLLIWVGNQALTIYLSFLIVLPLIYTNMLAGFESVDTQMLEMARVFRLSRWRTFMYVYRPAFMPFLSSSCKISLGMSWKSGIMAEVLATPKPSIGKEMSQARTYLDTPSLFAWTVVVMVLSWLFEKAFMALLKRVGRPLGGLLGKDDDR
>NZ_CP012069.2|WP_083444085.1|1041899_1042535_+|ABC-transporter-ATP-binding-protein
MEGLCKSYGDLRVLSHVSVRLKEGGIYCLMGPSGAGKTTLLRVLVGLESPDEGDVVGLEAGEASVMFQEDRLCEALTPVDNVALVMPPRASRRSIRELLEEILPADCMGRPALQLSGGMRRRVSLARAVAYPSRLIVLDEPFTGLDEATKGVVVRFLLRHRKGRTLLVSTHGEDDVGLLGARKLMLSDISATPAPVLQLGSHGRDGNDGRV
>NZ_CP012069.2|WP_050343864.1|1042538_1043444_-|putative-ABC-transporter-permease
MPSAAAPALAALWTMFFLYSVCGWVIESAYCSIPARRFINRGFLNGPYIPIYGTGSMIAVLLLEKLKGTLTIFVLGGLLGCVLEYVTSYGMERLYHARWWDYSSRPLNLNGRVWAGGFVEFGVGIVAVVRVAQPVMLSLVESVAPLTLVLFALVSAVVFFTDLIVTHVGVAGLKSKMDGLRVETGRRLARLRESLPARPELANIANWDSVINLSLRAQLEATTRKVREARRAVSALPGMSGLPTLPQLPTLDEMAKSFSATLSSQERRLMRAFPNMRPTNWRGALEEHRSSLQKALRGVRR
>NZ_CP012069.2|WP_062393174.1|1043436_1043955_-|hypothetical-protein
MSSKIPPFELLSRHCADILASEGMDIERRCMQHGTTSVAEHSLSVTLAGCALAQRLRIPVNERAFLRGMLLHDYFLYDWHVPDPSHRFHGFRHPGFARANAVRDFGVDRLEQNMIARHMFPLTPIPPSSREGWILCVVDKYVATRETIGGFVHRHLLRRASIASRGGERTHA
>NZ_CP012069.2|WP_050343870.1|1044885_1045659_-|YdcF-family-protein
MLAISLIICGAACILYGVSIMLVWSGTAFFALWYLMGAAAVAAGIAMRLGLWQHLPAALARGIGIASLVALAGVVSLSIFLMGVAATCDPNEAPDDLDYLVVLGAQVYGNKEPSVVLRFRLDAALSYLKGHEGCKVVVSGGRGPNEPITEAECMATYLERQGIPPERIVREGASTSTMQNLALSKEKMEQDSGTDVSQLRVGVVTNNFHVFRATRIAQRLGMPGATGISGSMDPWYVPNNLLRECLGVAKDALLGRL
>NZ_CP012069.2|WP_172674523.1|1045694_1046882_-|NADP-dependent-isocitrate-dehydrogenase
MRTPLVEMDGDEMTRIIWQMVKDDLICPFVELKSEYFDLGLRHRDETDDEVTVNAAEATRRLGVAVKCATITPNAQRVEEYGLKQMWKSPNGTIRALLDGTVFRTPIVVRGIEPQVRSWKRPITIARHAYGDVYRNVEIRVPGAGRAELVLTSADGTERRELIHEFTSPGVIQGMHNLDASIESFATSCLEYALATRQDLWFATKDTISKTYDHRFKDIFADLFEASYKERFEAAGIEYFYTLIDDAVARVMRSEGGFVWACKNYDGDVMSDMLSAAFGSLAMMTSVLVSPQGHFEYEAAHGTVQRHYYRHLKGERTSTNSVATIFAWSGALRKRGELDDTPELASFADRLEKATIDTIESGQMTGDLARITTFPKPQTLDTEQFILAVAEHLRP
>NZ_CP012069.2|WP_050343874.1|1047154_1047997_+|hypothetical-protein
MTNKWFRRFMSAFLALALALNPIDTRAFATRALATAPESAGINDMQRKATPGLGALGRGIAGAIGGLLGALGEAAVEEGTEHVGEAVEGAGETVEGAGETVGEAAEHVGEAAKGAEEAIKGAVEGGATAAEEGTTAAEGAAEQGAATAEEGTAASEEAGQKTAEEAQEQAAREFIERFNASGEKALDRLHGAQADHILHSNLHPEEHDWKQLFDGQEPTWEQVKSLLKKAIREGQESVHEDRLSQFERSIEYNGRRVFVRFVKGADGLVEHISTGYFKGE

Crispr_ID: NZ_CP012069_16

• CRISPR_ID: NZ_CP012069_16
• CRISPR_location: 1056764-1056935
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP012069_16

Consensus_repeat	Method
GGTACGCTCGGGGCCGAGTGGCAGTGC	CRISPRCasFinder

spacers of NZ_CP012069_16

>16.1|1056791|55|NZ_CP012069|CRISPRCasFinder
AAACTCGCCGTTCTGGTACGCTGGAGGCCGAGTGGCAGTGCAAATCAGACGTTTT
>16.2|1056873|36|NZ_CP012069|CRISPRCasFinder
CGGTCACACTGCCACTCGGTGGTGAACGTACCTCTC

CRISPR arrays and Neighbor proteins around NZ_CP012069_16

CRISPR arrays

The CRISPR arrays of NZ_CP012069_16

>merge|NZ_CP012069|16|1056764-1056935|CRISPRCasFinder
GGTACGCTCGGGGCCGAGTGGCAGTGCAAACTCGCCGTTCTGGTACGCTGGAGGCCGAGTGGCAGTGCAAATCAGACGTTTTGGTACGCTCGGGGTCGAGTGGCAGTGCCGGTCACACTGCCACTCGGTGGTGAACGTACCTCTCCTCACGTTCACAGTCGAGTGGCAGTGC

>NZ_CP012069|16|13|1056764-1056935|CRISPRCasFinder
GGTACGCTCGGGGCCGAGTGGCAGTGC	AAACTCGCCGTTCTGGTACGCTGGAGGCCGAGTGGCAGTGCAAATCAGACGTTTT
GGTACGCTCGGGGTCGAGTGGCAGTGC	CGGTCACACTGCCACTCGGTGGTGAACGTACCTCTC
CTCACGTTCACAGTCGAGTGGCAGTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050343913.1|1068796_1070458_-|putative-manganese-dependent-inorganic-diphosphatase	unknown	unknown	gnl|CDD|237843
NZ_CP012069.2|WP_083443809.1|1063338_1064877_+|ATP-dependent-DNA-helicase-RecQ	unknown	unknown	gnl|CDD|223588
NZ_CP012069.2|WP_172674444.1|1057132_1059232_-|DUF3825-domain-containing-protein	unknown	unknown	gnl|CDD|378984
NZ_CP012069.2|WP_050343893.1|1052232_1052724_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_172674443.1|1054708_1055317_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|379049
NZ_CP012069.2|WP_157051401.1|1053832_1054003_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343911.1|1067595_1068216_+|5'-deoxynucleotidase	unknown	unknown	gnl|CDD|378993
NZ_CP012069.2|WP_083444086.1|1050678_1050894_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343905.1|1062995_1063328_+|AzlD-domain-containing-protein	unknown	unknown	gnl|CDD|224601
NZ_CP012069.2|WP_050343898.1|1055595_1056525_+|1-phosphofructokinase	unknown	unknown	gnl|CDD|274464
NZ_CP012069.2|WP_050343901.1|1059247_1060267_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223730
NZ_CP012069.2|WP_050343909.1|1066514_1067384_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|223298
NZ_CP012069.2|WP_083443808.1|1062147_1062999_+|AzlC-family-ABC-transporter-permease	unknown	unknown	gnl|CDD|129446
NZ_CP012069.2|WP_050343907.1|1065152_1066469_+|ATP-binding-protein	unknown	unknown	gnl|CDD|379049
NZ_CP012069.2|WP_050343887.1|1050890_1051082_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343889.1|1051097_1051388_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343896.1|1053217_1053706_+|hypothetical-protein	unknown	unknown	gnl|CDD|184375
NZ_CP012069.2|WP_157051402.1|1054017_1054755_-|DUF4143-domain-containing-protein	unknown	unknown	gnl|CDD|379306
NZ_CP012069.2|WP_050343891.1|1051454_1052045_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050343903.1|1060482_1061919_-|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl|CDD|129794

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050343913.1|1068796_1070458_-|putative-manganese-dependent-inorganic-diphosphatase	gnl|CDD|237843	PRK14869, PRK14869, putative manganese-dependent inorganic diphosphatase.	0
NZ_CP012069.2|WP_083443809.1|1063338_1064877_+|ATP-dependent-DNA-helicase-RecQ	gnl|CDD|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	0
NZ_CP012069.2|WP_172674444.1|1057132_1059232_-|DUF3825-domain-containing-protein	gnl|CDD|378984	pfam12873, DUF3825, Domain of unknown function (DUF3825). Potential uncharacterized enzymatic domain associated with bacterial pfam12872 domains. Has conserved residues suggestive of an enzymatic role probably related to RNA metabolism.	1.15466e-25
NZ_CP012069.2|WP_172674443.1|1054708_1055317_-|AAA-family-ATPase	gnl|CDD|379049	pfam13173, AAA_14, AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	1.56267e-30
NZ_CP012069.2|WP_050343911.1|1067595_1068216_+|5'-deoxynucleotidase	gnl|CDD|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	5.55757e-107
NZ_CP012069.2|WP_050343898.1|1055595_1056525_+|1-phosphofructokinase	gnl|CDD|274464	TIGR03168, 1-PFK, hexose kinase, 1-phosphofructokinase family. This family consists largely of 1-phosphofructokinases, but also includes tagatose-6-kinases and 6-phosphofructokinases.	2.14028e-117
NZ_CP012069.2|WP_050343909.1|1066514_1067384_-|methyltransferase-domain-containing-protein	gnl|CDD|223298	COG0220, COG0220, Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only].	3.20998e-36
NZ_CP012069.2|WP_083443808.1|1062147_1062999_+|AzlC-family-ABC-transporter-permease	gnl|CDD|129446	TIGR00346, Uncharacterized_membrane_protein_HI_1738, 4-azaleucine resistance probable transporter AzlC. Overexpression of this gene results in resistance to a leucine analog, 4-azaleucine. The protein has 5 potential transmembrane motifs. It has been inferred, but not experimentally demonstrated, to be part of a branched-chain amino acid transport system. Commonly found in association with azlD. [Transport and binding proteins, Amino acids, peptides and amines].	1.34467e-96
NZ_CP012069.2|WP_050343907.1|1065152_1066469_+|ATP-binding-protein	gnl|CDD|379049	pfam13173, AAA_14, AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	3.62085e-21
NZ_CP012069.2|WP_050343905.1|1062995_1063328_+|AzlD-domain-containing-protein	gnl|CDD|224601	COG1687, AzlD, Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism].	1.33396e-33
NZ_CP012069.2|WP_050343896.1|1053217_1053706_+|hypothetical-protein	gnl|CDD|184375	PRK13891, PRK13891, conjugal transfer protein TrbE; Provisional.	0.00728811
NZ_CP012069.2|WP_157051402.1|1054017_1054755_-|DUF4143-domain-containing-protein	gnl|CDD|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	5.33919e-25
NZ_CP012069.2|WP_050343901.1|1059247_1060267_-|alpha/beta-hydrolase	gnl|CDD|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	8.82304e-37
NZ_CP012069.2|WP_050343903.1|1060482_1061919_-|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.09123e-59

Protein sequences

>NZ_CP012069.2|WP_050343898.1|1055595_1056525_+|1-phosphofructokinase
MIYTVTLNPALDKTATVENLRLDSVNRISELRVDPGGKGINVSKVVRELGAKTVAIALLGGHTGTMLRNMLAELGIECKVLEVEGETRTNLKIKDPALKTNTDINEPGPEVTDEQLRGMLDGLVGEVGGGDIVVLSGSLPRGAAADTYKVWVAALKKTGAKVYLDADGDKLVRGIEAKPDLIKPNEIELGAMMGRTLDADEKIVEAARELIDGGLDRVMVSMGGAGALYVARDVTIKANPVKVPVGSTVGAGDSVVAALAYAQDKGLGLEDTMRLAMATGAANVMQSGTQAAPRELVDSLIDKVVVTRL
>NZ_CP012069.2|WP_172674443.1|1054708_1055317_-|AAA-family-ATPase
MSQLAAWATTRRKTLLVTGARQVGKSFLVSMFAQDTFSSVVSLDLLEDRATRESLAAATSADDLMLRISIAARTPLVPQQTVIIIDEVQECPNILTFVKYLVQNDSYRFILTGSLLGTKLNNIDSLPVGYLTKIRMYPLDFEEFCWANGLSSVAVDMARSCLRTETPLPDFLYTRLSDLYHRYLMGGHAGCGKYLSGDEQHR
>NZ_CP012069.2|WP_157051402.1|1054017_1054755_-|DUF4143-domain-containing-protein
MPDAVNTFLETNNIDEVRAIHKNLHAHYRSDITKHAPKELRLTLRDIYDLIPSEAASKSRRFRISDIKGARRFSQVQEHFLWLSHAGVALSVYNVSAPASPLLLNERHNLFKLFYLDVGMLASSYPKKSYMGLLDGKPSMNMGGVYEAFVAQELKARGFALRYFTSKRLGELDFVVEMTGGEVLALEVKSGTGYRTHAALDNALAVSEYAIDQAIVLAETNIERAKSIRYLPIFMAGLLEHEERD
>NZ_CP012069.2|WP_157051401.1|1053832_1054003_+|hypothetical-protein
MTEWHERQVTDGRWRQDGGATRLDFKSYSVEVDVEATCRAHSRLPRTREKHGCVGD
>NZ_CP012069.2|WP_050343896.1|1053217_1053706_+|hypothetical-protein
MRLDFKNFSVEIDAEATRRAYEGLRRTDEGCSCDGCQNFPLAIGKALSEEGRRLFESMGVDPAKATEAYVNLARDEGTIFYGAWYHLFGRIERRVETVPDVTAPEWGKDVERDVGDNAFILFSDKRIDLKEDLFSGRADVVQMELFADVPWVLGKPNPYLDE
>NZ_CP012069.2|WP_050343893.1|1052232_1052724_+|hypothetical-protein
MRLDFKNFSVEIDAEATRRAYEGLPRTDEGCSCAGCQNFPLAIGEALGEEGRRLFESMGVDPAKAMEAYVNLACDEGTIFYGATYILFGRIERRVETVPDVTAAVWGRDRERWIGDNAHIFFADGEGVQLMEDAFRGSADVIQMELLADVPWVLDGPNPYLDE
>NZ_CP012069.2|WP_050343891.1|1051454_1052045_+|hypothetical-protein
MSGLDFPREGGEGLSPSGVGAGSPVAPGWRYAMTLDFENFSVEIDAEATRRAYEGVHRVDEGCDCAGCRNFTLAIGDGLGEGGRRFLASVGIDDLAKATESYVNFVQMDGTLCYGGWCHLCGRIRRRVEAVPDVTAAEWGEASVLHVGSRLDVSFRDGEDIIGREAAFGDAVIVQMEFVAWGVPWVLDEPNPYPDE
>NZ_CP012069.2|WP_050343889.1|1051097_1051388_+|hypothetical-protein
MDDALGGVDGTLLYGAWYRLCGRIERRFELPPGTTGREWRDAMARDVGDANVSFSEHVIGGKAGFGGGAVVQMDISARVPWVLDEPNTYLDTYLDK
>NZ_CP012069.2|WP_050343887.1|1050890_1051082_+|hypothetical-protein
MRLDFKSYSVEIDAEATRRAYEVLPRTDEACTCSGCRNFSLAIGDALGKGGRRFFEELGVDPA
>NZ_CP012069.2|WP_083444086.1|1050678_1050894_+|hypothetical-protein
MGENVCPVCGCGSLVEPAFNESGEGSYDICPCCACQFGLDDFPFEGGEGLVAEWRGRRDDGGQWRQDGGTR
>NZ_CP012069.2|WP_172674444.1|1057132_1059232_-|DUF3825-domain-containing-protein
MTPGNRLYLYQLLSTKIGIGRQVPLSQVEELLDKDGIDIMGLGYEGVRELVEELDDFMRLTVFKKGRVYATVTAHEAFDAILARLNESAATSGKDAGEGAATTAGKPTGAKTWKHRKSNKDPKPAKPRVRIRREARRKSDPDPEAVVEAASGAIGGDAEEPTPSPEPELGPEPQVEPEPEPEPEGDDRRAKDHVSTEGHISINITYNPYDYGELYLEDEGLVTESVEAQPEQGGTGRADPVSCATEDSAHAAKDPPPAAPTGGAATRQRYELFQSFSHDVWCKDEPLSLLYQVLPYDIEPMSVLEDDWRYARSTGTYEGTHSSIRFPLSFRASGSERPIVAQLHRSVKLHAGKAWALEAIDLGDVGDAALQEEALPLVGSDTRPNRTTQLERDLAKLFIIGSWESYLGELANLAAKERWGARDTLGLTTSGLAAPGGEIPPELSILCEYLALTLHRVHEEGQLLVSHDGQLAAFNTGLLSTGAEAIFDVLLSNEGDIHWQHTGFCTAGSGELGTLLSHSLDEPPRAASYLTSLDEVTLRPRAHVELGEEVRSQLGDSADDIVEKSVRRARSSYRLLVPAYDPAPSTHVSGSEGGDVVSLLPLWGEDPTQPKEPREPKEALLLRRAKVKRTLDETDGMASGVDGTADGLDAVHGLNAVHGLDASPRYVAEELLPPAQAYSRARAICADLPSWLTSSLDGG
>NZ_CP012069.2|WP_050343901.1|1059247_1060267_-|alpha/beta-hydrolase
MDKTSKTLLRAAATVIGIAGAAAGFEGVSRLKWGRSGVATAWAGYQRTTGTRAALLGRDLRRYEDYVAHHREENEREYVIPRWVPIKSLIFEETCDGMKTYHLGTTGMNERAVLYLHGGTYISQISSLHWLFADKLCRDTGAEVCVPIYPLAPAHDHDEAYSLLVDLYEGMVNRYGADKITIVGDSSGGGLAAGIVETFGHYDLPQPAQLVLVSPMLDISMRNPQIHEYFDIDPVLAPWGIAQIGDLWADGDDVTLPRLSPINGDVSILRNVTTFVGTREIFYPDCVKWDEKLEAAGINHKLVVGVGLNHNWPLSPIPEARVARKQIAGIVGAGAKGVR
>NZ_CP012069.2|WP_050343903.1|1060482_1061919_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MQQEITKPFTRVMNARLIASVVATGIMSFSGVVVETAMNVTFPALMREFGVNTSTVQWMTTAYLLVLAAIIPTSAYLNRRFRTKRIFMAAMSLYILGIVLGLTAQSFPWLLCGRIAEGIGTGIALPLMFNVIQEQAPKRSMGLMMGVGSLVTAMAPAVGPSLGGWLAETFGWRSIFACLLPLLLVGFVLGALTIQQSHPAKRDRFDLVGWLLLVMAFTSLVLAASEMGTGGPSSPTVLGLIAASATLLALFTLHASHAETPLISLGTFRDSRFDLGLMALIGLQFIVLGLSFLFPNYSQLTLGHGPTEAGSILLPGCLLGAMMAPVSGRLLDAFGARRPILTGACAVLLACVLLWLTAPSCETPMATCIYLLFAFGQGLMVGNTMTHALGGLADARKADGTAIINTLQQLTGALGTSVVTAVVATAQASAGVSASEAGSALSAATTNGTQGALALLVGVATLVFVAEVLSLCAHRDRT
>NZ_CP012069.2|WP_083443808.1|1062147_1062999_+|AzlC-family-ABC-transporter-permease
MDGLWYGELSQRGTLVDKTSRKRADRVLKKEGGERRARALIALRAAFPNTIPILAGFLFLGMTYGIYMHGLGFPFVYPTLMAMTIFAGSLEFVIGNMLVGAFDPLQAFAISLMINARHIFYGLSMLERYRGYGWRSVYLIFGMCDESFSINYAVDAPEGVDEGWFMFFVTLLDQVYWVLGATLGGLLGNLLAFDTKGLDFVMTALFVVIFLDRWLKEESHVSSVLGLVLTTLCLVAFGSSSFVVASMVAILAALTLMRPKLDRRTRGTDARGKVVAAGDGDSR
>NZ_CP012069.2|WP_050343905.1|1062995_1063328_+|AzlD-domain-containing-protein
MTLTQQLIVIALAVAATLLTRFLPFVLFPARRPVPSYVRYLGEVLPAAVFGLLVVYCLRDVGWTQGWHGAPELISILVVVALHLWRRQMLLSIAGGTICYMLLVQLVFVS
>NZ_CP012069.2|WP_083443809.1|1063338_1064877_+|ATP-dependent-DNA-helicase-RecQ
MADIADARAALERHFGYPSFRPGQGEIIEAVLAGRDALAVMPTGAGKSVCYQVPAAVLPGLSIVVSPLISLMGDQVRALKDVGIRGSYLNSSLTARQQEVVMARAMAGWYDLMYVAPERLADPRFIWFASRLRVPLVAVDEAHCVSQWGQDFRPAYQGIADFVEALPQRPPVVALTATATERVRADIAGLLRLHDPLVQVTGFDRPNLSLSAFELTPKQRGRWIESYVRSHQGQSGIVYVTTRKGVDELSEALRAVGVRAAAYHAGRDNASRLAAQEAFVRDDVEVMVATTAFGMGIDKPDVRYVVRSGLPLSLEEYYQEMGRAGRDGEPAECYLLWSKGDIRTCHFFIDHTEFAPELSVEERRQLVLNRERLLFAMIDYARGNRCLRGRILSYFGQGPGVKGEGGCNNCSVCRAETAETYLRQRAATVRRRLEGDGELGGDDERLFQRLRALRRELADGAGVPAYIVFSDATLRAMARMRPHTPEELLEVPGVGEVKLGRYGSAFLDVLGG
>NZ_CP012069.2|WP_050343907.1|1065152_1066469_+|ATP-binding-protein
MLRRKILDTLREWKGSHGTECLLVNGARQVGKSFAIEAFGRAEYESYIAIDFVRQPALKGIFGESLTPDDMYSRMTLLMPNVRLVPGNTLIFIDEIQECPEARSAFKYLAQDGRFDVIGSGSLLGIRFRTLRDAPSLPVGYERQLTLRPLDFEEFLWARGYTPESIVSLRGFYERMEPVPQSIHREMMRQLREYLAIGGMPAVVQSFVDGAGDFGAAHSQQLMLHALYLDDIARYASVSERIKARACYLSLTRQLARENTRFRYAEVERRSSARKYESSVDWLVEANMALRCNAVTTPSFPLASYEDGSRFRLYANDTGLLMAMFDFSMKAAVVENTLKGPMKGGLYENLIAGMLSQKNKPLRYWMSKDSKREIEFLADLDGCVVPIEVKASRGSTVSLNQLLEGDDVNIGYKFIDGNVSVNGKKVTLPLYMAMFPFA
>NZ_CP012069.2|WP_050343909.1|1066514_1067384_-|methyltransferase-domain-containing-protein
MRTLHARLPKNFVLEERLERYANAIEVEPSRYVGHWAEACFPLRREDGEIKGEGATPCRYREVRLDLGCGKGDFTAEMARREPDVLFVGVDFEPICIAYAAERAVKARLKNIVLVSATGENVGSIFGPGELAAIYLNFPTPFPKKKEATRRLTHLIRLMEYQPLLAPGATVLLKTDSYPLWRFSETQFRLADYTITWQSMDARAERPDDAMSQYEERLTAKGAKVLAIEATPGPESVYREQTACREQTAPLSLVDWLPDDLDTMDYVPYGMEGTVTNLRNRRRKQRRKR
>NZ_CP012069.2|WP_050343911.1|1067595_1068216_+|5'-deoxynucleotidase
MPTQNESPAKESHFLAILSRLKYIERWSLMRNSRPENLSEHSLEVAMIAHMLCVIGNVRHGRHLDAAHAALLGMYHDASEIITGDMPTPVKYFNGKIRDAYKGVEAQAERRLLSTLPDDLRPEFVQAFSADDGADGRYVARLVKAADKLSALIKCLEERAAGNTEFATAEASTLRKLEDMRVELPEVDDFMDEFLPSYGSTLDQLL
>NZ_CP012069.2|WP_050343913.1|1068796_1070458_-|putative-manganese-dependent-inorganic-diphosphatase
MPETIRKVNIIGHLHPDTDSICSAIALAYLKNQTGDIEYEPRRAGTLNRETIFVLKHFNFEEPQLITSVRPQIKDITIQDMHGIDPEMSLFAAWNLMSETKTDTLCITDGERDLMGLIAVKDIANANMNVFDTKIIAESKTLYSNILSTLKAHMLLGDPDEKVDAGKVVVGTTPEMMEGNIERGDTVLVTNRYETQRFAVESGAACLVVCNDARISNVVLDAAKANGCTVMTTPYDTFSAARLISMSIPVRSKMLDADKVLRFSVNTTVDDARKTITQSRHRFFPVVDEDGRYVGLVSTPNLLNVNQKHVILVDHNERSQAVDGLEQAVIMEIIDHHRIGSIETTAPALFRNEPVGCTCTILFSMYQEAGIEIPSNIAGLMLSAILSDTLAFRSPTCTKRDEYAARELARTCGEDIDSYADAMFDAGAELTGRTAEEVFHQDFKVFSRGSARFGVGQGSFMTENSRKAAEALVGPYLKEGADADELPMVFYMFTDVKSATTEMLYFGAHAEDVVRRAFNVTPKDGIATLPGVVSRKKQVIPALMSTLQDTQDE

Crispr_ID: NZ_CP012069_17

• CRISPR_ID: NZ_CP012069_17
• CRISPR_location: 1364981-1365074
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_17

Consensus_repeat	Method
TAGTGCCCCGCAGATTCTGGGGTACCGAGTTT	CRISPRCasFinder

spacers of NZ_CP012069_17

>17.1|1365013|30|NZ_CP012069|CRISPRCasFinder
TGGGATCCAACTGGGCAAATGTCTCTGCGA

CRISPR arrays and Neighbor proteins around NZ_CP012069_17

CRISPR arrays

The CRISPR arrays of NZ_CP012069_17

>merge|NZ_CP012069|17|1364981-1365074|CRISPRCasFinder
TAGTGCCCCGCAGATTCTGGGGTACCGAGTTTTGGGATCCAACTGGGCAAATGTCTCTGCGATAGTGCCCCGCAGATTCTGGGGTACCGAGTTT

>NZ_CP012069|17|14|1364981-1365074|CRISPRCasFinder
TAGTGCCCCGCAGATTCTGGGGTACCGAGTTT	TGGGATCCAACTGGGCAAATGTCTCTGCGA
TAGTGCCCCGCAGATTCTGGGGTACCGAGTTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_157051581.1|1362737_1363793_+|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl|CDD|234934
NZ_CP012069.2|WP_050344318.1|1368127_1369075_+|DNA-processing-protein-DprA	unknown	unknown	gnl|CDD|223829
NZ_CP012069.2|WP_050344309.1|1355571_1356153_+|signal-peptidase-I	unknown	unknown	gnl|CDD|274044
NZ_CP012069.2|WP_050344319.1|1370391_1371324_+|tyrosine-recombinase	unknown	unknown	gnl|CDD|234698
NZ_CP012069.2|WP_157051414.1|1366638_1368135_+|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl|CDD|223679
NZ_CP012069.2|WP_050344314.1|1364624_1364966_+|50S-ribosomal-protein-L19	unknown	unknown	gnl|CDD|376502
NZ_CP012069.2|WP_050344322.1|1373538_1374258_+|UMP-kinase	unknown	unknown	gnl|CDD|239787
NZ_CP012069.2|WP_050344315.1|1365109_1365889_+|ribonuclease-HII	unknown	unknown	gnl|CDD|260003
NZ_CP012069.2|WP_050344312.1|1359276_1359684_+|kinase/pyrophosphorylase	unknown	unknown	gnl|CDD|377080
NZ_CP012069.2|WP_050344316.1|1366078_1366630_+|YraN-family-protein	unknown	unknown	gnl|CDD|237119
NZ_CP012069.2|WP_050344308.1|1354826_1355579_+|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	unknown	unknown	gnl|CDD|234581
NZ_CP012069.2|WP_050344306.1|1354005_1354305_+|KH-domain-containing-protein	unknown	unknown	gnl|CDD|224750
NZ_CP012069.2|WP_050344321.1|1372479_1373349_+|elongation-factor-Ts	unknown	unknown	gnl|CDD|236491
NZ_CP012069.2|WP_050344323.1|1374268_1374820_+|ribosome-recycling-factor	unknown	unknown	gnl|CDD|178850
NZ_CP012069.2|WP_050344313.1|1359874_1362640_+|pyruvate,-phosphate-dikinase	unknown	unknown	gnl|CDD|236446
NZ_CP012069.2|WP_050344311.1|1357112_1359206_+|glycine--tRNA-ligase-subunit-beta	unknown	unknown	gnl|CDD|234925
NZ_CP012069.2|WP_172674452.1|1354338_1354830_+|16S-rRNA-processing-protein-RimM	unknown	unknown	gnl|CDD|234650
NZ_CP012069.2|WP_050344310.1|1356190_1357111_+|glycine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl|CDD|236473
NZ_CP012069.2|WP_050344809.1|1369064_1370405_+|methylenetetrahydrofolate--tRNA-(uracil(54)--C(5))-methyltransferase-(FADH(2)-oxidizing)-TrmFO	unknown	unknown	gnl|CDD|235416
NZ_CP012069.2|WP_050344320.1|1371603_1372401_+|30S-ribosomal-protein-S2	unknown	unknown	gnl|CDD|235396

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_157051581.1|1362737_1363793_+|deoxyguanosinetriphosphate-triphosphohydrolase	gnl|CDD|234934	PRK01286, PRK01286, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	1.82361e-164
NZ_CP012069.2|WP_050344318.1|1368127_1369075_+|DNA-processing-protein-DprA	gnl|CDD|223829	COG0758, Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion].	4.10774e-71
NZ_CP012069.2|WP_050344309.1|1355571_1356153_+|signal-peptidase-I	gnl|CDD|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	5.51809e-48
NZ_CP012069.2|WP_050344319.1|1370391_1371324_+|tyrosine-recombinase	gnl|CDD|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	4.05134e-107
NZ_CP012069.2|WP_157051414.1|1366638_1368135_+|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl|CDD|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	3.38544e-160
NZ_CP012069.2|WP_050344314.1|1364624_1364966_+|50S-ribosomal-protein-L19	gnl|CDD|376502	pfam01245, Ribosomal_L19, Ribosomal protein L19.	8.79399e-60
NZ_CP012069.2|WP_050344322.1|1373538_1374258_+|UMP-kinase	gnl|CDD|239787	cd04254, AAK_UMPK-PyrH-Ec, UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and via gene repression of carbamoyl phosphate synthetase (the first enzyme of the pyrimidine biosynthesis pathway). The UMP kinase of E. coli (Ec) is known to function as a homohexamer, with GTP and UTP being allosteric effectors. Like other related enzymes (carbamate kinase, aspartokinase, and N-acetylglutamate kinase) the E. coli and most bacterial and chloroplast UMPKs (this CD) have a conserved, N-terminal, lysine residue proposed to function in the catalysis of the phosphoryl group transfer, whereas most archaeal UMPKs appear to lack this residue and the Pyrococcus furiosus structure has an additional Mg ion bound to the ATP molecule which is proposed to function as the catalysis instead. Members of this CD belong to the Amino Acid Kinase Superfamily (AAK).	1.5031e-140
NZ_CP012069.2|WP_050344315.1|1365109_1365889_+|ribonuclease-HII	gnl|CDD|260003	cd07182, RNase_HII_bacteria_HII_like, Bacterial Ribonuclease HII-like. This family includes mostly bacterial type 2 RNases H, with some eukaryotic members. Bacterial RNase HII has a role in primer removal based on its involvement in ribonucleotide-specific catalytic activity in the presence of RNA/DNA hybrid substrates. Several bacteria, such as Bacillus subtilis, have two different type II RNases H, RNases HII and HIII; double deletion of these leads to cellular lethality. It appears that type I and type II RNases H also have overlapping functions in cells, as over-expression of Escherichia coli RNase HII can complement an RNase HI deletion phenotype. In Leishmania mitochondria, of the four distinct RNase H genes (H1, HIIA, HIIB, HIIC), HIIC is essential for the survival of the parasite and thus can be a potential target for anti-leishmanial chemotherapy. Ribonuclease H (RNase H) is classified into two families, type I (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type II (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H endonucleolytically hydrolyzes an RNA strand when it is annealed to a complementary DNA strand in the presence of divalent cations, in DNA replication and repair.	6.96835e-82
NZ_CP012069.2|WP_050344312.1|1359276_1359684_+|kinase/pyrophosphorylase	gnl|CDD|377080	pfam03618, Kinase-PPPase, Kinase/pyrophosphorylase. This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity.	1.98686e-21
NZ_CP012069.2|WP_050344316.1|1366078_1366630_+|YraN-family-protein	gnl|CDD|237119	PRK12497, PRK12497, YraN family protein.	3.14354e-33
NZ_CP012069.2|WP_050344308.1|1354826_1355579_+|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	gnl|CDD|234581	PRK00026, trmD, tRNA (guanine-N(1)-)-methyltransferase; Reviewed.	1.33337e-129
NZ_CP012069.2|WP_050344306.1|1354005_1354305_+|KH-domain-containing-protein	gnl|CDD|224750	COG1837, COG1837, Predicted RNA-binding protein (contains KH domain) [General function prediction only].	4.76908e-20
NZ_CP012069.2|WP_050344321.1|1372479_1373349_+|elongation-factor-Ts	gnl|CDD|236491	PRK09377, tsf, elongation factor Ts; Provisional.	6.88656e-119
NZ_CP012069.2|WP_050344323.1|1374268_1374820_+|ribosome-recycling-factor	gnl|CDD|178850	PRK00083, frr, ribosome recycling factor; Reviewed.	1.11519e-89
NZ_CP012069.2|WP_050344313.1|1359874_1362640_+|pyruvate,-phosphate-dikinase	gnl|CDD|236446	PRK09279, PRK09279, pyruvate phosphate dikinase; Provisional.	0
NZ_CP012069.2|WP_050344311.1|1357112_1359206_+|glycine--tRNA-ligase-subunit-beta	gnl|CDD|234925	PRK01233, glyS, glycyl-tRNA synthetase subunit beta; Validated.	0
NZ_CP012069.2|WP_172674452.1|1354338_1354830_+|16S-rRNA-processing-protein-RimM	gnl|CDD|234650	PRK00122, rimM, 16S rRNA-processing protein RimM; Provisional.	5.64063e-14
NZ_CP012069.2|WP_050344310.1|1356190_1357111_+|glycine--tRNA-ligase-subunit-alpha	gnl|CDD|236473	PRK09348, glyQ, glycyl-tRNA synthetase subunit alpha; Validated.	0
NZ_CP012069.2|WP_050344809.1|1369064_1370405_+|methylenetetrahydrofolate--tRNA-(uracil(54)--C(5))-methyltransferase-(FADH(2)-oxidizing)-TrmFO	gnl|CDD|235416	PRK05335, PRK05335, tRNA (uracil-5-)-methyltransferase Gid; Reviewed.	0
NZ_CP012069.2|WP_050344320.1|1371603_1372401_+|30S-ribosomal-protein-S2	gnl|CDD|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	1.66055e-154

Protein sequences

>NZ_CP012069.2|WP_050344314.1|1364624_1364966_+|50S-ribosomal-protein-L19
MDYIRAIERQQIREDIPKVRVGDNVKVHYHIKEGEREREQVFQGDVIRMSGGSSRETFTVRKISFGIGVERTFPLHSPKIARLEIVRHGDVHRAKLYYLRDRVGKAARIREKR
>NZ_CP012069.2|WP_157051581.1|1362737_1363793_+|deoxyguanosinetriphosphate-triphosphohydrolase
MSGVEQERREHGLLGPRACYADQSRGRARKEVPDRLRTCFQCDRDRILHSKSFRRLANKTQVFLAPEGDHYRTRLTHTLEVSQIARDIARSLRLNEDLVEAIALGHDLGHTPFGHTGERALSRAMARFRGIDPTSVEGKSLFQHNEQSVRVLERLERDGRGLNISFEVLDGIRCHRGSLRATTLEGRVVARADRIAYVCHDIDDAERAGLLVEDMLPPDARNVLGHTSSERIETMVRDVVDASAGADDVLMSQRVWDALMELRAFLFDKLYTQGDAKYEEPKAERMIGSLFDYFVTHLDDMPREYRGHDVSHPDVEVADYVSGMTDRYAVRIFEELTVPHAWREPVLHRDR
>NZ_CP012069.2|WP_050344313.1|1359874_1362640_+|pyruvate,-phosphate-dikinase
MAEKHVYRFGMDEHGNNVTEVAGSSVNEAKWITGGKGSNLAEMANIGLPVPPGFSITCQTCVAYSSAGNVWPEGVLDEIDEYRRDLERRMGKKIGDETDPLLVSVRSGAPFSMPGMMDTVLNLGLNDKSVQGLIKQTNNERFAWDSYRRFIQMFSSVVMGVEGQLFEDAINEKKAEKGVKLDTDLTAEDLKELTETFKRIFAKNVDSQAHPEVAPEGVASFPQDPYLQLRLAEQAVFGSWNTERAVLYRKQNKIDDSLGTAVNVQVMVFGNKGDSSATGVAFTRNPADGTNERYGDFLVNAQGEDVVAGIRNTEPIADLVKIPALKEAGEQLFHVFEILEDHYADMMDIEFTIEQGKLWMLQTRVGKRTALSALKVAMQMVEEGRITKEQAILRVAPDQLDQLLHPQFDPKAKFDVAAKGMNASPGAAVGAVVFSSDAAVHYANIEKPCILVRWETTPDDLKGMVAAEGILTSHGGKTSHAAVIARGMGAPCVCGAEALRIDAAKKEVAISGTNIVLHEGDIISIDGTTGNIIVGEVPLKRPELTGDLETMLEWADDVRHDASRGRIFGVRTNADNPEDAQLSVDFGAEGIGLDRTEHMFLGERKQIIQTFILADTNGQKQQALGQLLKAQTGDFMGMFKAMDGKAVIVRLLDPPLHEFLDDPRELAVEIAHAEGRGENDTQLEAMRERLARLDSFQEANPMLGLRGCRLGIVYPELNDMQVRAIAGAAATLKKQGLDPRPEIMVPLISTVEELKLVREQIQSVIKAVEEAEGLELSIPIGCMIELPRAAVTADEIGAYADFFSFGTNDLTQTTFGFSRDDVESAFIPQYLNKKILKANPFETLDVGVAKLVEMGVKGGHAANETIVCGICGETGGDPDSIQMYYDLGLDYVSCSPYRVPIARLAGAQAKINSNGGPKKLG
>NZ_CP012069.2|WP_050344312.1|1359276_1359684_+|kinase/pyrophosphorylase
MSEDTLDDIDIFADVTPVVFVLSDARGKTAASVVEAAADQFNDKVVTIKQLGNVKSVGMVCDYLDNNVTEDVPMAVFHTIVDRNLRRDIRRELDGRGIPSIDLLGPAITVISTLTGEEPKYEAGRRSDNEVSVTS
>NZ_CP012069.2|WP_050344311.1|1357112_1359206_+|glycine--tRNA-ligase-subunit-beta
MAEAKDFLLEIGCEEMPSAPLMSAQGQIGTLIERGLTEVGLAHGSIKTLSTPRRLAVIVRDLATATEEIREVKRGPAARIAFGEDGVPTKAAEGFARKLGISATELIRRVDGDGREYVFAERFVPSRESVPILSELSRRVIASLEWPNYRSQRWGSEHASFVRPIRWICALFGSEVVPFGYADVTSGNTTRGHRVLAPGEHVVTDPAHYEQILRHAYVMGEVERAQRIRAGISEVQTHASVQVDTPKRTFDEVVNLCEWPHVLVGRFDEEFLQVPTEIICESMLSHQRYFPIYDKDHRLTREFVIVSNADPACDATVIDGNERVVRARLDDAKFFWEEDLKRPLEDFVERLSTVTFQERLGTVLQKVQRMEAIAAEVARRAGASERDTAYAKRAAHLSKADLVSQTVIEFTNQQGIMGGYYAQAAGEPPEVARAIREHYRPRFASDELPSDLIGKAVAIADKLDTICGVFAIDEAPTGSSDPFAVRRAAIGTIAMLRTLPLVPLRALIDLSLDSYLMQGLSFDRGRVAGAVAAFFAGRLAAIAREEGAAPDVIDAVSSVGVIDPMEFMDRVEALGSARLEEPEVFEDLATAYARAAHLADRSLGYKIDEGIMGDAERSLLEACRRGSADVKKALSKRDYRAACKALADLREPIDRFFDDVLVMDDDTVVRENRLKLLNLFAAVFDDVANIGALSKKG
>NZ_CP012069.2|WP_050344310.1|1356190_1357111_+|glycine--tRNA-ligase-subunit-alpha
MGDDILTFQDMILRLERYWADKGCTVMQPYDSEVGAGTFHTATLLRSLGPAAWRTCYPQPCRRPTDGRYGKNPNRMQHYYQFQVILKPSPADSQELYLGSLTAIGLDPAEHDVRFVEDDWESPTLGAWGLGWEVWVDGMEVTQYTYFQQVGGIEVDPVPVEITYGLERIAMYAQGVDSVYDIIWSYLPDGTPMTYGTVFLENEREFSIYNFEVADVGLMREKFDEYEAECHSCLEHRLPLPAYDCVMKCSHAFNLLDSRGAISATERANYILRVRAIAKACCESYLSEVATAGAAAGENARTGEVA
>NZ_CP012069.2|WP_050344309.1|1355571_1356153_+|signal-peptidase-I
MSDGDAGTRRGREGILWELLQWLGSVAFVFILFVLLRIFVFGVYYVPTGSMTDTIQVGDQLIGEKISYRFTSPKVGEIVTFDDPDGSGETLIKRIIATSGQTIDIHDGKLYIDGVEQEESYTKSRPTYALTEHAANLSGGIKYPYRVPEGCVWLMGDNRTNSLDSRYFGAVSTTRISSHALFIYLPFKDARTL
>NZ_CP012069.2|WP_050344308.1|1354826_1355579_+|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD
MIFEVLSVFPQVFEPYLSESILGRAWQRSLFEFVAHDLRTWTHDRHSTVDDAPFGGGQGMLMKCEPIFEAVRDISGQGKKRPHVIFFSPCGRRYSEKDAERLSSFDRILFVCGRYEGIDERAYALADEIVSVGDYVLTGGELAALVVIDSVVRLLPGVLGDDRSAKDESFSQGLLEYAQYTRPATFQGERVPEVLLSGDHGAVSAWRRRSSIERTARWRPDLLEGAELSEDEWSLVHETLGQRDCEATDV
>NZ_CP012069.2|WP_172674452.1|1354338_1354830_+|16S-rRNA-processing-protein-RimM
MEKTHGRQGEIVAVDVNGLGTYLRPGMWVWAVPPRLKGPRSFVVGRVRGNGHGWLVSLVGVDSIAHASRLVGRTLLVAVDELPDDFELHDARELVGRRVRDLLLGEIGHISEVTLGVANDAWTIEGETGTFVIPVVGEYVLGIDNEGELVVNLPDGVREGRDG
>NZ_CP012069.2|WP_050344306.1|1354005_1354305_+|KH-domain-containing-protein
MAGQAAISGAPLGQAEQGLPSDRVADLVEYIVCGLVTDEDRVSLDVTDGEGSALIEISCAEDDAGRVIGKRGRTIKAIRTLARALGSRVGTAVEVEVLG
>NZ_CP012069.2|WP_050344315.1|1365109_1365889_+|ribonuclease-HII
MPWSERRPMSAQEVAALLARASHDEALALIERYATDPRTQVQRAIRSAKRRLAKEETERRRVEGMYELQRSLGGDGLVMGVDEVGRGALAGPLTVCAVILPQEPKIWGIDDSKRLSPARRLELAKRIREQACAIGTCHVEATSIDAVGMSVALRVAMAGAIEDAGVEPDCVLIDGRAVHAHPKERALVRGDSRIAAIAAASIVAKVTRDKMMVDYDVKYAGYHLASCKGYGSAEHIRAIQEHGLTPLHRTSFCKNFMDT
>NZ_CP012069.2|WP_050344316.1|1366078_1366630_+|YraN-family-protein
MGNAACASRTIFGRGDIEEFVCKDVGDSSLSDAEELREREDAWEAVLSEATNVNGKPPCDMSEKELGDQGELLAESYLRQRDYEILARKYKNLGGEADIIAREDDCVVFVEVKTRLTSPQDEDIVPELAVTLDKQERYRKIALYYLIDHRESNFVRFDVIAIKIHGERQASLRHLVGAFVCDL
>NZ_CP012069.2|WP_157051414.1|1366638_1368135_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MTNIRIGSACLWGVEALPIQVEVASSGGLPGFSIVGLPGAGVMDARSRVRCALKACGFKMPRLHFTINLAPAEIRKNGTGFDLPIAIAILALSGQIPTDGLERCLFVGELGLSGEVCETRGTVAYQVLCRKIGATFVCSHESAVLRMDGCGLSVIRSLNELREGVGRLDRPRGEPSRPAVPDHSLDFADVYGQEEAKRALVIAAAGSHGLLMVGPPGAGKTMLARRLPTIMEPLTDEELEEVLLVSSVAGQLSRATLARARPFRAPHHSISRGGLIGGGRPVTPGEISLAHRGVLFLDELPEFSTSVLQSLRQPMEDGVVQLVRVDGTYRFPCEFQLIAASNPCPCGYLGDPSHGCSCSPARIQCYQSRIGGPLMDRIDIHVGVQRPQSDLVIEGAAGMDSKTMRALVMGARELRLRRERREGRPDDALVESLLFKPEARSCLEGLSSRMALGARSIVKMAQVARTIADVEQSERVGRVHVLEASSYRNRMGGDGIDG
>NZ_CP012069.2|WP_050344318.1|1368127_1369075_+|DNA-processing-protein-DprA
MGDRWVLTKGDGAWPQALDDLEDPPEWVFGIGSRDVLHESCISIIGARRASPYGLSVARLAGRVAAECGIVVVTGGAMGCDVTAARAALDAGGKTIVVTGTGADVTYPRSSEDVFARAVTRGAVVSLENWGQTPRRYAFPKRNRIIAALSQSILICEAGLRSGTFSTALAAGQMGRDLYAVPGSIFSPESMGANQLIAEGAHIIASEIDLEQRISLDFGMLRMVGEGVPRQEGRILSALMSEPTRPDDLARYLAEPVTSILVALSDYEGAGMVKRLPDGRYSLSESAYLARDRMVGHHEKKRIGRPDQEGNGDAG
>NZ_CP012069.2|WP_050344809.1|1369064_1370405_+|methylenetetrahydrofolate--tRNA-(uracil(54)--C(5))-methyltransferase-(FADH(2)-oxidizing)-TrmFO
MRDSAVTVVGGGLAGSECALQLARRGVSVRLVEQRPVATSPAHHTADFAELVCSNSLKSTRHDSAAGLLKEELRAMGSILLELALKARLPAGSALAVDRERFSALVGERIEAQDLIKVERREVTRLPEGPCVIAAGPLCSRALFDDLARRLGRGALSFFDAAAPIVDGESLDTDIVFAQSRYEQTEGGDYLNCPLDRREYDAFCEELVSAERVVPRDFERAELFMACQPIEEVARSGHDSLRFGALKPVGLTDPRTGRRPWAVAQLRAENVRGSAYNLVGFQTNLRWGEQERVFRMIPGLAHADFFRYGVMHRNSFVDAPRVLDSSFAIPGTSCRLAGQICGTEGYTEAIASGLLAAINTYAELSGLDRLTLPKTGALGSLVSYATDPATEPYQPMHVNFGLVLPLEGPRLKKRERYRAYADRAMSDLERCLEDRDDLFGSSYARA
>NZ_CP012069.2|WP_050344319.1|1370391_1371324_+|tyrosine-recombinase
MPEPEKSQEPNSRFSQLKEGFLNFLLDVRTLSHNTARAYGCDLDAFGSWAERHGIDPLGATHRDLRGFLGELSRAGYAPRTINRRLSAVRSFYRWLEREGFAREVTIDAVLGPKIPRSLPTTLSDEDVTRLMESCGDDAVGIRDATLIELLYATGARLFELSRLTVLSIDFDEGQVKLFGKGSRERIVPLYPQVLARVRDYMEDARIQLVSHARGGDTGALFVSTRGNAMGTGALRDAFKRRAKESGIDPDVTPHSLRHSYATELLAGGADLRSVQELLGHASLSTTQIYTHLSIDRLKKAARQAHPRAG
>NZ_CP012069.2|WP_050344320.1|1371603_1372401_+|30S-ribosomal-protein-S2
MAVKINIRTLLEAGCHYGHQTRRWNPKMREYIFGERNGIYILDLKKTVLGADRAYSFLKDVASKGGKLLFVGTKKQAQEPIATQAERCGMPYINQRWLGGMLTNFVTMRSRIDRMEELETMVEDGSMALRGKKEQAVLTKELEKLQRNLGGVRDMKSLPQAVFVVDSKREEIAIREANRLNIPVIALLDTNSDPDVVDFGIPANDDAIRSVGIMCELVADAILAGTGQEQISVEEMSSGETTPAVEVTEGVEATGNTEADAPVAE
>NZ_CP012069.2|WP_050344321.1|1372479_1373349_+|elongation-factor-Ts
MAKISAAMVKQLREMTDAPMMECKKALVEADGDLEKAVDVLRTMGIAKAVKRAGRATNEGTIAAYVAESGKAGALLELSCETDFVGTNPKFTAFARDLARVVCESDPSDVEALKGCAMGKATVADALTEMIHVIGENMKIVRFQRVSVENGALSSYVHLGGKLADIVMFSFSNAATAERDEFKTFAHDVAMQVAASAPVAAKREDVPAQTIEREKAIYLAQATDSGRPEAIWETIANGKLEKFYKQIVLTEQVFIKDSSLTIFELAKRTSDACDDTIGIEGFVRFSFGE
>NZ_CP012069.2|WP_050344322.1|1373538_1374258_+|UMP-kinase
MSDYKYKRVLLKLSGEALMGSNDFGIDPTVPEKIAGYIEPAYKANVQIAIVVGGGNIFRGLSGAAAGMDRAQGDNMGMLATVINSLALQDTFERNGMQSRVMSAIEMHQVSETYIRRRAIRHLEKKRITIFAAGTGNPYFTTDTAAALRACEIGAEVLMKATKVDGIYDADPVTHPDAKKYDTITYTDVLMRGLQVMDGTATALCQDNHMPIMVFNLNGRDSFERALRGESVGTTVVDE
>NZ_CP012069.2|WP_050344323.1|1374268_1374820_+|ribosome-recycling-factor
MSEYTDAAKKQMERSIEALGHNFAKVRTGRANPHVLDDIRVNYYGQPSPINQLAGIKSDASMLIVEPWDKGLLKEIEKAISSSDLGITPSNDGSCIKLPFPKPTEERRRELAKECRKYAEAAKISVRNSRRDANGLAEKDEKAGDISEDDANREKKAIQKLTDSYIDKIDELLKAKTAEVMEL

Crispr_ID: NZ_CP012069_18

• CRISPR_ID: NZ_CP012069_18
• CRISPR_location: 1715577-1715727
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_18

Consensus_repeat	Method
GACGCAGGAGTGTACACAAATCGGTGGAAATGGCCCCTCGGGGCCGTTT	CRISPRCasFinder

spacers of NZ_CP012069_18

>18.1|1715626|53|NZ_CP012069|CRISPRCasFinder
TGGGGCATTTGTGTACACTGTTGGGCCGTTGCGCTGTTGTGGACAGACGTGGG

CRISPR arrays and Neighbor proteins around NZ_CP012069_18

CRISPR arrays

The CRISPR arrays of NZ_CP012069_18

>merge|NZ_CP012069|18|1715577-1715727|CRISPRCasFinder
GACGCAGGAGTGTACACAAATCGGTGGAAATGGCCCCTCGGGGCCGTTTTGGGGCATTTGTGTACACTGTTGGGCCGTTGCGCTGTTGTGGACAGACGTGGGGACGCAGGAGTGTACACAAATCGGTGGAAATGGCCTCTCGGGGCCGTTT

>NZ_CP012069|18|15|1715577-1715727|CRISPRCasFinder
GACGCAGGAGTGTACACAAATCGGTGGAAATGGCCCCTCGGGGCCGTTT	TGGGGCATTTGTGTACACTGTTGGGCCGTTGCGCTGTTGTGGACAGACGTGGG
GACGCAGGAGTGTACACAAATCGGTGGAAATGGCCTCTCGGGGCCGTTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_172674461.1|1721842_1724161_-|isopeptide-forming-domain-containing-fimbrial-protein	unknown	unknown	gnl|CDD|372367
NZ_CP012069.2|WP_050340526.1|1727044_1727875_-|HAD-hydrolase-family-protein	unknown	unknown	gnl|CDD|319819
NZ_CP012069.2|WP_050340511.1|1706825_1707872_-|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP012069.2|WP_157051437.1|1719050_1719224_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083443881.1|1713252_1715283_+|glucan-binding-protein	unknown	unknown	gnl|CDD|369832
NZ_CP012069.2|WP_050340512.1|1708189_1709506_+|alpha-amylase	unknown	unknown	gnl|CDD|200452
NZ_CP012069.2|WP_050340517.1|1715979_1716870_-|DUF4261-domain-containing-protein	unknown	unknown	gnl|CDD|379456
NZ_CP012069.2|WP_050340518.1|1717143_1717626_-|tetratricopeptide-repeat-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340521.1|1719457_1720657_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340524.1|1724788_1725577_+|hypothetical-protein	unknown	unknown	gnl|CDD|368639
NZ_CP012069.2|WP_050340514.1|1709641_1710205_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340509.1|1705439_1706783_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|224567
NZ_CP012069.2|WP_050340519.1|1717759_1718563_-|hypothetical-protein	unknown	unknown	gnl|CDD|373946
NZ_CP012069.2|WP_172674460.1|1710730_1713055_+|L,D-transpeptidase-family-protein	unknown	unknown	gnl|CDD|341130
NZ_CP012069.2|WP_050340522.1|1720660_1721542_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340507.1|1704463_1705339_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP012069.2|WP_050340525.1|1725687_1726626_+|N-acetyl-gamma-glutamyl-phosphate-reductase	unknown	unknown	gnl|CDD|237004
NZ_CP012069.2|WP_050340503.1|1702345_1703530_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|236947
NZ_CP012069.2|WP_050340501.1|1701344_1702028_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NZ_CP012069.2|WP_050340505.1|1703600_1704464_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050340511.1|1706825_1707872_-|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.27075e-97
NZ_CP012069.2|WP_050340519.1|1717759_1718563_-|hypothetical-protein	gnl|CDD|373946	pfam15569, Imm40, Immunity protein 40. A predicted immunity protein with an alpha+beta fold and conserved phenylalanine and tryptophan residues and a GGD motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox19 family.	0.000182843
NZ_CP012069.2|WP_050340525.1|1725687_1726626_+|N-acetyl-gamma-glutamyl-phosphate-reductase	gnl|CDD|237004	PRK11863, PRK11863, N-acetyl-gamma-glutamyl-phosphate reductase; Provisional.	3.66131e-173
NZ_CP012069.2|WP_172674461.1|1721842_1724161_-|isopeptide-forming-domain-containing-fimbrial-protein	gnl|CDD|372367	pfam12892, FctA, Spy0128-like isopeptide containing domain. The FCT and equivalent region genes of Streptococcus pyogenes and other related bacteria encode surface proteins that include fibronectin- and collagen-binding proteins and the serological markers known as T antigens. Some of these proteins give rise to pilus-like appendages. The FctA family is found in many Firmicutes and related bacteria. In S. pyogenes, the pili have a role in bacterial adherence and colonisation of human tissues. Members of this family have a conserved N-terminal lysine and C-terminal asparagine that can form a covalent isopeptide bond.	1.39768e-28
NZ_CP012069.2|WP_083443881.1|1713252_1715283_+|glucan-binding-protein	gnl|CDD|369832	pfam08363, GbpC, Glucan-binding protein C. This domain is found in the Streptococcus Glucan-binding protein C (GbpC) and also in surface protein antigen (Spa)-family proteins which show sequence similarity to GbpC.	2.86267e-96
NZ_CP012069.2|WP_050340512.1|1708189_1709506_+|alpha-amylase	gnl|CDD|200452	cd11313, AmyAc_arch_bac_AmyA, Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase). AmyA (EC 3.2.1.1) catalyzes the hydrolysis of alpha-(1,4) glycosidic linkages of glycogen, starch, related polysaccharides, and some oligosaccharides. This group includes firmicutes, bacteroidetes, and proteobacteria. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	8.97154e-169
NZ_CP012069.2|WP_050340517.1|1715979_1716870_-|DUF4261-domain-containing-protein	gnl|CDD|379456	pfam14080, DUF4261, Domain of unknown function (DUF4261). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, and is approximately 80 amino acids in length.	1.89453e-27
NZ_CP012069.2|WP_050340524.1|1724788_1725577_+|hypothetical-protein	gnl|CDD|368639	pfam05857, TraX, TraX protein. This family consists of several bacterial TraX proteins. TraX is responsible for the amino-terminal acetylation of F-pilin subunits.	4.49191e-21
NZ_CP012069.2|WP_050340526.1|1727044_1727875_-|HAD-hydrolase-family-protein	gnl|CDD|319819	cd07517, HAD_HPP, phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily. Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	5.30506e-43
NZ_CP012069.2|WP_050340509.1|1705439_1706783_-|ABC-transporter-substrate-binding-protein	gnl|CDD|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	3.93778e-17
NZ_CP012069.2|WP_172674460.1|1710730_1713055_+|L,D-transpeptidase-family-protein	gnl|CDD|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	8.07611e-12
NZ_CP012069.2|WP_050340507.1|1704463_1705339_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.79154e-64
NZ_CP012069.2|WP_050340503.1|1702345_1703530_-|ABC-transporter-ATP-binding-protein	gnl|CDD|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	2.28315e-170
NZ_CP012069.2|WP_050340501.1|1701344_1702028_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.1443e-25
NZ_CP012069.2|WP_050340505.1|1703600_1704464_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.32331e-62

Protein sequences

>NZ_CP012069.2|WP_083443881.1|1713252_1715283_+|glucan-binding-protein
MRRTHLRRIGAVSLSLLMVLMLLFLNTRLALATDPVRGVEVKVDTSALDASVDAAKQAGVDVQKDGDVDKGTADSEAELNAKRDEIKADYDKQVQDLNAAAEDAKKQLGEYAAKKQKYDEDMVKYNADLAKYNTDMAACNKALEELEQKKNQDGYMTKPSAQMLTFKSEPNASLSFSEKKYTKEEFKSTVRSWNLGPEPWRYAWFDFLNDNQPEDAARVMLEKDKPFVATYTNLSNSSFNGTKIAKVEYIYTFKGASGVPLPDKLPVVLQKDPADTIWYNDFFADVRINLKARFYDEEGKEIDPTGSLLSFSSLNRGNGSAAIDRDALERVAYFNGEYIPISGSSIKVHADGGAYADSSNADKAKGSKFDTAEWDTPTSPNAWYGAIIGKVTNPEISLDMASHKSGTIWFAFSSDVKARDVPMKPVAPTPPVEPKKPVIKANYHVDILYTRPQLGKGALDEADADIDGSTVKTGSIVKFALRTSAFPADHETIDSVVFRDTLPESYEVDLDATKATSPDYDVSYDGASRNLVFTAKATLIAQINADLTKAAEVPAPMVIGKVMKDGTTYENSFDIDINNSYSAKSNIVRVQTPKAQPIILPAAGGPGTPLPVTLLSVLAVVSGAAWLFTRRREVWRGAGAWYGREAYSPLKSSGMRRAFDVRGKWRSILARCHFNR
>NZ_CP012069.2|WP_172674460.1|1710730_1713055_+|L,D-transpeptidase-family-protein
MAKAASAEPDVPAAVAVTDDSNPSVPVAAAEVTQGEGSAAKAPVVGAAEGTTTSNVEASNSQPSKTEVPTVSPAPADTVASSARATRDGTPVASDTQTDEKTASTKALASPSVPASSSSSTSPTTDAGAAVSKNVSVAPTHAPSTETSAPTFGTPTSPDAPAATSLGADERSADVETAAPSSKTTAYANVYRLFNPWTTEHLYTTDLSEAKGLASLGWNWEGIAWVTPSAGASVYRLYNAFSGDHLYTARRSEYDTLVKRGWRGEGVQFRSVGSKDGTAVRRLFNRYVTTGTHFLTTSVEEEHSCVRVGWKSEGTAWYAARHAPLDILGFWFDRFDGTRWWVDATGTLANSRVIDPTSGRDRGSGRYAYARASGSILRDGTADAGGGWSYLADNDGRLVHHRGSGWVVTASWPRSGRQLQRYWTQDKGSYSLVRHGIFIAKGETGVGACYLGRADTGYVVRGAWGSGTIIYLADNDGRLAAGSGWQVTGRYGQGLQRYYLYSMGSYSVARHGLSSDGARGAGGIGASHLTTNQGYVLRGIADAGDGWSYLADNDGRLVHHRGSGWVVTAAWPFSDRQLQRYWTQDRNLCSLVRVGHFEVSGSRYFGRTDTGYVLRNADLDIDGIPYHADNDGRLTIHDPMIARAQGYASSTDTLVLVDTTDHWVGVFRGSQGNWRLDRRMRCSTGAPRTPTVIGNFTVGIRGYSFNGSNYTCYYYTQFYKDYLFHSIVYHIGTFRVLDGRIGYSVSAGCVRLEIDNAKWIHDTVPTESTVITYR
>NZ_CP012069.2|WP_050340514.1|1709641_1710205_+|hypothetical-protein
MESTLLEQIRSGHLILAVCCILYLAWWAIFFWPKVTGGKAKGAMRLLGIVALIGAIITGTVGATLICDGANTLMEKTPQTPLMIFGGAAIIYAALLTVTWKMHNRQPTVELALFVAWLGMEVLVACAFNVLGKGGEANILADLSIVGFGVSLVCYNFYYKLKSLSSFIDGCVPLALIGVISVVIFVL
>NZ_CP012069.2|WP_050340512.1|1708189_1709506_+|alpha-amylase
MATTTDPALQGQIIYSVYVRNHTTEGTFAAVEPDLGRIRNLGCDIVWLMPIHPIGRVARKGTLGSPYANSDYRAINPEYGTMDDFKSLVNAIHAQGMRVMIDVVYNHTSPDSVLFEQHPEFFYRRKDGTPGNRVGEWSDIIDLDYRVPGLWDYQIETLRRWAKIVDGFRCDVAPFVPIEFWKRARAAVKEVNPRFTWLAETVHRSFGEAVRREGTYCATDNEAFEAFDIEYSYDVEEAFERYLKGEIPLSCYLDLLDFQESVYPRNYNKLRFLENHDLPRIASQLTEHLDLKNLTSLLYLLKGTTLIYAGQELCATHKPSLFDKDPIAWDGFGSARDLTPLMQTMARIKHEVLGTDDFIRYAADDANDIAVIDRLGTGGRSVGVFSLKSHTAPVKLDLPDGSYLNLIDDSSVQVTEGRLLCTGQPVVLHVDTGVEAMV
>NZ_CP012069.2|WP_050340511.1|1706825_1707872_-|LacI-family-DNA-binding-transcriptional-regulator
MTIKDVAKYCGVSVSTVSRVMNGHPDVSVSVRAKVLAAVSELHYVPNRSAQDLVRVRSDSIGVVVRGASNPFYSPIVRSIERVCEDKGYTMIVHHMGERGDEVKRGAELVNSKRLKGLILLGGRFDYGERERASVMVPFVCCAFSSQFGRLDGATYSSVSIDDAKEARRATRLLTDEGHRKIAILVDFVNDQSISELRYRGYRQALEEVGITLDEDLVLEAGGFSMAHAYSAVTRLLTARSDVTAIFSASDAMAMAAMKAVYDAGRRIPEDCSVVAIDGIEASRYAIPTLTTLEQPTEVMGRRAATTLIDQIEGRAGMRHVTLDAKIRRGGTLGPVPRTKEIPHHRDA
>NZ_CP012069.2|WP_050340509.1|1705439_1706783_-|ABC-transporter-substrate-binding-protein
MSFNAKQVTRRTFVGGAGLAIAAGLVACGGKSTTKGGTSGTSSEDRSGNVYWLNFKPEMDEAIQSLGKKYMEKYPKVKVKIVTAASGTYTQTLTSEMDKQGAPTLFVIGNMEGVKTWSDYAMDLKDTAIAKELSTDDYNLTDDSGKLVSIPYNYEAFGIAVNTELIEKAGHKMDDIKDFNSLKKVVEDIHSRASELGFDAFVATDMDDSSSWRVTGHLTNIVCYYDSRDAGGWKQAPATISDKYIPNYKNLYDLAINNSTVAPNALATGGHDPVTEFTGKKAAFIFSGSFNYADIKKGGVTSTACIPYYCGVQGEEKAGLNCGTENRWAINDNASEEDKQATMDFMVWLVTDPDAAAAMVAANGTMPYKQTPEGDNPYLNDAKKYSDAGNYIMDWDFSYTPNVNDFRSKLVSALNAYNNAPSDSTWEGVKKAFVDGWAEQYKKANPS
>NZ_CP012069.2|WP_050340507.1|1704463_1705339_-|sugar-ABC-transporter-permease
MGIKRSRGNSQRRATRRWAWLFMGPVVIAFIIGFVWPFIQGIYLSFCKFKLVSNAQFVGVSNYGEALADAGFQYSFWYTAATAVVSLVLINVIAFAVAYALTQGIRGSNLFRTVFFMPNLIGGIVLGYIWSMIFDGILQAYQTSILLDTTYGFWGLIILMCWQQIGYMMIIYIAGLQAVPEDMIEAAKIDGATKAQTLFKVIIPNVMPSITICTFLSLTNGFKLFDQNLALTGGQPFNTTEMMALNIYNTFYTSGAVVRGVAQAKAVIFFVLVAGLGLIQLAYTRKREVQQ
>NZ_CP012069.2|WP_050340505.1|1703600_1704464_-|carbohydrate-ABC-transporter-permease
MAANNKDLASDRTQKTVLSVLLAIVCIIWVLPVVAVIINSFKLNTYVKTDTFSLPNEESFAGLQNFVTGMTFGNYPFWKAVGYSAFITVAATFLILLCCSMAAWYIARVDSTFCKIVYYLCIFSMVVPFQMVMFTLSKTADVLKLNTPWAIPIVYLGFGAGLAIFMFVGFVKSIPLEIEEAAAIDGCGPVRTFFSVVLPMLRPTLISVGILEIMWVWNDYLLPYLTLDINEYRTIPIHIQYLKGSYGTVDLGATMALILLAIIPVVVFYLIAQRYIIKGVAAGAVKG
>NZ_CP012069.2|WP_050340503.1|1702345_1703530_-|ABC-transporter-ATP-binding-protein
MAELSLKHIQKIYPNLEKKRKRKKGELEKKSNLKVTDEGVIAVEDFNLEVADGEFVVLVGPSGCGKSTTLRMVAGLEEISGGELYIGGKLMNDVAPKDRDIAMVFQSYALYPHMTVYDNLAFPLKLRKVSKDEIDKKVREAAQVLGITEYLERKPKALSGGQRQRVAIGRAIVRNPKVLLMDEPLSNLDAKLRNQMRAEIIKLRQRIDTTFMYVTHDQTEAMTLGDRIVIMKDGVVQQVGTPQQVFDSPANLFVAGFIGVPQMNFFDATLSHAGARYVVKAEEISVSVSDETATKLVAAGIRDGVSVVAGVRPEQILICEKGEAGSVAGTVDVTELMGSTVHVHVTTDIGQFVLIVPTVDLGGKSYTTGDEISFKFAKNAIHLFAKDTGVSLTA
>NZ_CP012069.2|WP_050340501.1|1701344_1702028_-|ATP-binding-cassette-domain-containing-protein
MELRIDIGYDRKRPLYTDVCLSFARGDIINVVGDNGSGKSTLYKTLCGSIPPLRGKIPREVADSCMLVSDTIRPPSELLVSDVFDLLGNSASTVRDAYPQISSVLGPLMGRRIGSLSFGQRRILEIASVLSSSKSILILDEALANLDFINRLACIQIVQRLDDQVVFNTSHDLGDVIELGGRIIFLDRRAHAFVEYEGERTVESLRKFMGSRILTATSDYGNRGISC
>NZ_CP012069.2|WP_050340517.1|1715979_1716870_-|DUF4261-domain-containing-protein
MDNEVFKQNLEGESIRPGGPVIIQMLFKGPVAMPGKEQMAAAMARHLGSVECICHDEKTAGFAALEHVAKFSDGTAPVQLMVTGCLDFEGSKFDSFSISQMWDCREERERILCECRYQVVAMDMLAAALPALERTKVDMDFLGALAELYPDCKAVYFQSCGKLFSMDDLRSFQGEGPDRFIRFGVNVRLFNIQGTKDMLVDTVGMGTLFLPDLQYHFHDMDPNQVVSHAYDLASYILENDNPIQDGETVDSVRDGRMCPELQWSCRYERALIQPPREVLDVHMGEYASGSGRQATL
>NZ_CP012069.2|WP_050340518.1|1717143_1717626_-|tetratricopeptide-repeat-protein
MASLCHDLAWDLLDEGLLSDAEALVREELVAVRFLATYDPETFLLNVADACENLAGILWEGGHPEEVEPLLREALECYRTLAASDPDEDGLPALIPEAGPPMGVLATILAEEGRAKEAEELFREGLSMYAILARAHPEREDFRLGEEAFRESLAQLSAGV
>NZ_CP012069.2|WP_050340519.1|1717759_1718563_-|hypothetical-protein
MDELSFEKTYQDGGLVRLWVSASSGLCGARRGLYEDEAAVKAAAGEVLGYSRDFSRGRSVALGRWEGGPAPALSLRILPADSRGHVTLEVDMEIDDDGDRHAHRARFFVKSELGPVGRFGASLLSLARGPVGSHATLNDDLGGLPWYMAEGGPARVGAPLVGKGGILPERMLGSAVRLGGPGTDRYAWGRDAAVAIAGYLGVRGVPILGGCAWRMLPGGGEARDGDGWRDEEGALSGSAMGCCLRAMEYIESHSRERGEDYLYELIC
>NZ_CP012069.2|WP_157051437.1|1719050_1719224_-|hypothetical-protein
MLELGDYDIGFVKWLGKERMWDRRVCPGEGIGAVAGQADRSDAGKPRVLGASRCGWT
>NZ_CP012069.2|WP_050340521.1|1719457_1720657_-|hypothetical-protein
MPEVREVVRLMRESGVELGRGMGEGELSLAEASCNVRFPRSLRALLSAALPLAEAGEGRFPDWRDLSPRNLRLLRAQLCAPAGPIGEESLVRWPRAWGARPLTADGRRLGLHRRLALAPRLVPLYLSRFVPEGCGDDPPVLSVSGRRVLCMATGLGDWAAREFRGVSPRGTWPSAPAPVPVWDDLMPAAGQPGGHASVSAPPRARRVPPPAGAADVARLMAKAGVSLAPGLSRAELSAAERACGAPFPRSLRALLQGAMPASWQGRFPFPDWRDTSDMGRLRLSAWASEAEDALLWLGLGGRWPEGWGTRPGSRAARTRALGRRLATAPRLVPVASRCYVPAGCGDDPPVISVWAGEVACLGESLGDWVARTFGSPWDAPCLPVPAFPPVPFWGDLMLL
>NZ_CP012069.2|WP_050340522.1|1720660_1721542_-|hypothetical-protein
MTVNGVIFQRRADGLWAWRKGREYRGVDGDDWYLEDELWDVREQPWRALRDRVVGYLGALEERSHFDPGLLVAIDDPSWIRLYAEVSEALGVGYRMLLCETDLARPAMGDLGLECDFLGYDCAWPGGDCCSAVLCDLVGGRVFELSDVPLNANGLIPTREAAEAFLWRRERLKARYPESSFEGGDFVVYRLGEVVAVPSVLRVAQVPPDEGPRPAWDLRGACGPPEAPIGGGRARRPCRGPCGPRDGRLWKDLGSGLVRVSGPGALAWWRDGGPGAPGAGTPPVGPCSDMGEG
>NZ_CP012069.2|WP_172674461.1|1721842_1724161_-|isopeptide-forming-domain-containing-fimbrial-protein
MAELVKRMQTRRHHRYPSARILLGCCLFAVTLVLCLAPRLAYADSVRKVDDLLGSVGGTVYFLHSPSKWNGQYWDGGGWKNIKDIPRDPNTTSADLGNGWVMCYRFGGYVAWRKDKLPIDEPGTTFGGFKLRFNDVGVTERRENFDVIIEFTKITAWAPYDQKGEGAPALSGYAPLEVDDVGGLLLAARSEEDRNPTIRSTYRTRFVKRGTDELIDSSNEVDMVYWSIDAPEGVRHGSGNYTNPNRESIWKVSGYKDEALVRQDVDEWLEIVPGEDGIANKGFLSKKEDVLGSIQDNHSMVVLKSGPEFVTEWRGYNCEMWMGYDTVVKAYPEWTGPVIDPPTQVKRRGETAELGVRQTFPHVVFNKAKSVVMSDTLDPALDASKAEVKVYKDDTDVTRFWEVDVSGQTVTAKSRNTSLVDGNMTLKIRVPVSETADLSSYEQQDDQGVKYWKIPNQASTTINGVSKQAERAYVLVPGEATGSVQLRATTRLEGGQLKDGQFTFRLRDEGGNELDVKTNDADGNVVFKALDYTSADIGKTFSYTITEDAGTEPGYSYDTHVETLTVKVEDGGQGRPSASVTYDADGATFVNSYGQQTQRAALAVVRQDGKTHAPLGGAQFTLYVDDGDGSFTSADQPAVTYIDEALKNPIAGSVVTTRSDDGRAVYYGLEWGKTYWLKETTAPSGYGPDPQVHKIGVSTDGAVSTIGKDGQAEALPNQGGIPTITISGDPRFVLPGAGGVGIVGTLLVGMVLVLSGGVCAFVSKRRAARGYR
>NZ_CP012069.2|WP_050340524.1|1724788_1725577_+|hypothetical-protein
MDTTKGTGLCNAFQLKLLALAVMMLDHTNIIFGPNTVPDWLHFISRFVSPLFAFLVVEGFFHTHDRRRYALRLWGVGLFVAAGNLVVGQLTHHLVSLISHTIILTLALGYSVIWAIDEGRRQGGTKGGRLFALAAALGIAGALIAPVEGFVQVLFVMLASYLLHDAKGGRAKLCLCLVLGSAALACLYTPILHPSTASAVEWEMSLGLNADWAQFMAVPFILLYNGERGPKGTLSKWLFYLGYPAHLWAFAVIGMLLGIPSL
>NZ_CP012069.2|WP_050340525.1|1725687_1726626_+|N-acetyl-gamma-glutamyl-phosphate-reductase
MSRTKVYIDGQSGTTGLQIHDRIEAREDLRLLRICDERRHDVEERRKFLNDADIVFLCLPDEGARQAVSLVENPDVCVIDASTAHRTADGWVYGFPELSLGQRRAIASSRRIANPGCHATGLISVAAPLVRMGILPADYPLCCFSLTGYSGGGKRMIARYEADGRDGALDAPGIYGLDLTHKHLPEVQRVCGLAQPPVLMPVVDDYRQGMATTIMLHSRLLKGAPSAREVCEELRGYYTDQHFVSVMPFDPTPPTIHANELAGTNRLRITVCGNAERISVTALFDNLGKGAAGAAVQNMNIALGLDEVTGLE
>NZ_CP012069.2|WP_050340526.1|1727044_1727875_-|HAD-hydrolase-family-protein
MGSVMAQSGKATVFFDIDGTLGWTDPNKRDALPEWERGLSPTPSPRVAAAIRSLVARGNHAFLCSGRSPVGIHPDLAALPFSGIIALAGAYVTMGDEVLRDRPLPADVLAHIDRVLAAGGYGALIESAHGAVELRGGALGRRSGTPDTMDEAIGQLPDGCAYKLVIRSSAADELVADPQLGSQLVASRLEMQNSEVGLACNTKKAGIEAVLSHLGDNVGVTYGFGDSENDLTLFSEVDVSVAMGNAIPEVKRLADYVTDSVSEDGVASGLEHLQLV

Crispr_ID: NZ_CP012069_19

• CRISPR_ID: NZ_CP012069_19
• CRISPR_location: 1822474-1822562
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_19

Consensus_repeat	Method
GCCCCGCAGGCTGGCGGGGGGTTGCTC	CRISPRCasFinder

spacers of NZ_CP012069_19

>19.1|1822501|35|NZ_CP012069|CRISPRCasFinder
GAGCGCATTTGCCCAGTTGAGCCATTTTCCATAGT

CRISPR arrays and Neighbor proteins around NZ_CP012069_19

CRISPR arrays

The CRISPR arrays of NZ_CP012069_19

>merge|NZ_CP012069|19|1822474-1822562|CRISPRCasFinder
GCCCCGCAGGCTGGCGGGGGGTTGCTCGAGCGCATTTGCCCAGTTGAGCCATTTTCCATAGTGCCCCGCAGGCTGGCGGGGGGTTGCTC

>NZ_CP012069|19|16|1822474-1822562|CRISPRCasFinder
GCCCCGCAGGCTGGCGGGGGGTTGCTC	GAGCGCATTTGCCCAGTTGAGCCATTTTCCATAGT
GCCCCGCAGGCTGGCGGGGGGTTGCTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050340593.1|1819351_1820011_-|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl|CDD|239264
NZ_CP012069.2|WP_050340601.1|1828434_1829664_-|hypothetical-protein	unknown	unknown	gnl|CDD|373052
NZ_CP012069.2|WP_172674466.1|1823060_1823678_-|PH-domain-containing-protein	unknown	unknown	gnl|CDD|367615
NZ_CP012069.2|WP_050340599.1|1826373_1827687_-|ATP-binding-protein	unknown	unknown	gnl|CDD|379306
NZ_CP012069.2|WP_157051447.1|1829660_1830956_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340604.1|1833230_1834976_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_050340594.1|1820164_1821106_-|4Fe-4S-binding-protein	unknown	unknown	gnl|CDD|223425
NZ_CP012069.2|WP_050340603.1|1831712_1833206_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|223562
NZ_CP012069.2|WP_050340587.1|1809777_1810581_+|HAD-family-hydrolase	unknown	unknown	gnl|CDD|369792
NZ_CP012069.2|WP_050340600.1|1828033_1828420_-|SMI1/KNR4-family-protein	unknown	unknown	gnl|CDD|379649
NZ_CP012069.2|WP_050340592.1|1818021_1819125_-|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|273593
NZ_CP012069.2|WP_050340605.1|1834978_1836724_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_050340598.1|1824921_1825980_-|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|176245
NZ_CP012069.2|WP_172674465.1|1821115_1821286_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340589.1|1812880_1814083_-|ATP-binding-protein	unknown	unknown	gnl|CDD|379306
NZ_CP012069.2|WP_050340588.1|1811258_1812173_-|Abi-family-protein	unknown	unknown	gnl|CDD|377910
NZ_CP012069.2|WP_050340590.1|1814279_1816022_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_050340591.1|1816022_1817822_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_050340595.1|1821464_1822145_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NZ_CP012069.2|WP_050340597.1|1823838_1824852_-|cobalamin-biosynthesis-protein	unknown	unknown	gnl|CDD|223597

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050340593.1|1819351_1820011_-|TlpA-family-protein-disulfide-reductase	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.22091e-21
NZ_CP012069.2|WP_050340601.1|1828434_1829664_-|hypothetical-protein	gnl|CDD|373052	pfam14411, LHH, A nuclease of the HNH/ENDO VII superfamily with conserved LHH. LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved histidines of which, the first one is predicted to bind metal-ion and other three ones are involved in activation of water molecule for hydrolysis.	6.37796e-21
NZ_CP012069.2|WP_172674466.1|1823060_1823678_-|PH-domain-containing-protein	gnl|CDD|367615	pfam03703, bPH_2, Bacterial PH domain. Domain found in uncharacterized family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure.	1.12194e-09
NZ_CP012069.2|WP_050340599.1|1826373_1827687_-|ATP-binding-protein	gnl|CDD|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	7.76266e-32
NZ_CP012069.2|WP_050340604.1|1833230_1834976_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.30884e-124
NZ_CP012069.2|WP_050340594.1|1820164_1821106_-|4Fe-4S-binding-protein	gnl|CDD|223425	COG0348, NapH, Polyferredoxin [Energy production and conversion].	1.85137e-18
NZ_CP012069.2|WP_050340603.1|1831712_1833206_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl|CDD|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.88852e-69
NZ_CP012069.2|WP_050340587.1|1809777_1810581_+|HAD-family-hydrolase	gnl|CDD|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	3.12486e-63
NZ_CP012069.2|WP_050340600.1|1828033_1828420_-|SMI1/KNR4-family-protein	gnl|CDD|379649	pfam14567, SUKH_5, SMI1-KNR4 cell-wall. Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins.	1.85855e-09
NZ_CP012069.2|WP_050340592.1|1818021_1819125_-|HAMP-domain-containing-protein	gnl|CDD|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	7.95674e-54
NZ_CP012069.2|WP_050340605.1|1834978_1836724_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.80809e-146
NZ_CP012069.2|WP_050340598.1|1824921_1825980_-|NAD(P)-dependent-alcohol-dehydrogenase	gnl|CDD|176245	cd08285, NADP_ADH, NADP(H)-dependent alcohol dehydrogenases. This group is predominated by atypical alcohol dehydrogenases; they exist as tetramers and exhibit specificity for NADP(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like other zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), tetrameric ADHs have a catalytic zinc that resides between the catalytic and NAD(H)binding domains; however, they do not have and a structural zinc in a lobe of the catalytic domain. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
NZ_CP012069.2|WP_050340589.1|1812880_1814083_-|ATP-binding-protein	gnl|CDD|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	8.43582e-49
NZ_CP012069.2|WP_050340588.1|1811258_1812173_-|Abi-family-protein	gnl|CDD|377910	pfam07751, Abi_2, Abi-like protein. This family, found in various bacterial species, contains sequences that are similar to the Abi group of proteins, which are involved in bacteriophage resistance mediated by abortive infection in Lactococcus species. The proteins are thought to have helix-turn-helix motifs, found in many DNA-binding proteins, allowing them to perform their function.	3.79864e-61
NZ_CP012069.2|WP_050340590.1|1814279_1816022_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.00972e-126
NZ_CP012069.2|WP_050340591.1|1816022_1817822_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.27251e-135
NZ_CP012069.2|WP_050340595.1|1821464_1822145_+|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.66118e-76
NZ_CP012069.2|WP_050340597.1|1823838_1824852_-|cobalamin-biosynthesis-protein	gnl|CDD|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	2.97075e-39

Protein sequences

>NZ_CP012069.2|WP_050340595.1|1821464_1822145_+|response-regulator-transcription-factor
MKILVVEDERELLESIGEGLELDGYYVDLCDNGPEALAMAEVESYDLILLDLNLPGMDGLDILRSLREGRSKSRVLILSARSGVPDRVVGLDAGADDYLIKPFAFEELEARIRGLFRREYTQQSSELSYGELSFDTVSRTMYAKGAAVSLTKKETAIAEYLLRHSGRPVSSEELLAHAWDSNVDLFSNAVRVHIHTLRKKLGSKLGYDPIGNRVGEGYYLRNGTDA
>NZ_CP012069.2|WP_172674465.1|1821115_1821286_-|hypothetical-protein
MKTDLSLGLTRLRIRAAPLLLLCLGTAFVAFGAWRGETNTVFAKAVRLCLECVGIG
>NZ_CP012069.2|WP_050340594.1|1820164_1821106_-|4Fe-4S-binding-protein
MKKALTRVGSFLRRRGTVQAIAAFLTNPHIPNFLTGTLYTGPAKRVCVPGLNCYSCPAATGACPIGAFQAVVGSSKFSFSYYITGILILIGTLLGRFVCGFLCPFGWVQDLLHKIPFPKKFSTKRLKALRYLKYAILIVMVWVLPALINNAAGMGDPYFCKYVCPQGILEGAIPLSLADEGIRAALGKLFAMKLSVLMTVVLLSIMFYRPFCKWICPLGAFYSLFNKVSFLQYRVDKNTCISCGKCARVCKMDVDITKNSSHLECIRCGECVKACPVHAISTKLSLLDAKLAATAPATAGAKARSCAGRGDTR
>NZ_CP012069.2|WP_050340593.1|1819351_1820011_-|TlpA-family-protein-disulfide-reductase
MKIMKNALASVATALVVFALSGCGASTTNTQGTQGTASSTGGSSQQSSEMAETSNVPPEAASKLHLKDGDTFPTFKATNISNDETVTNDVFKKNKVTVLSFWFNGCTACVGEMPLLQELSEKYKDKGVGVIGVNAEAAYTTDGKKDAQEILSKQGVKYDNIALDPKNGGQVIEGITAFPTTMLVDQDGKLIGNPTTGAIGDKLDGSDLVKRIDEALAKS
>NZ_CP012069.2|WP_050340592.1|1818021_1819125_-|HAMP-domain-containing-protein
MAIPKGLSRAVGSLRARLTLLMVGLLVCCCVALTLLVYHSTTVVLEVAALQPAQQGGLSIQLDADGIKRTILSDALIVLALVVIVGSGAAYLVAGRYTKPIQQLSARMREMELATLSQPIEVEGGGGEIQELVRSFNQMTRQLSEAFAMQRRFSASAAHELRTPLAVLRTKIDVFKKRQRSQVEYDELLGTVETYVGRLSSIVADLLELTDTGELPDVRQVSLGSVLERVVADLGPLAREGGVLLSCDATPLEVRGNTDLLYRAIYNLVENAIRYNFEGGRVEVRLISRGEDIVVTVSDTGMGIEPDARELVFEPFFRVNKSRSREFGGAGIGLSLVKTILARHGAGIEVGENQPHGSVFTVTFPAG
>NZ_CP012069.2|WP_050340591.1|1816022_1817822_-|ABC-transporter-ATP-binding-protein
MAEKKGRATIARIMDFAGTRRPLTAVGCALVAISMVLTMMPYVFIWLVVRELIAVAPRWGEAASVVGYGWAAFGFAVAGIVVYFLGLMCTHLAAFRIESNMRKACAKRLIAAPLGYYDIHASGILRRRMDAATLNIEQLFAHNLADISGTVAMFVSLVILLFVFDWRMGLACFATVIISVVCIMQMMSGKGKKFMAEYQSALDRMSKASTEYVRGIPVVKVFQQTVYSFTTLKRAIDEYSARAEQYQGEVCAVPQSVNLSFIKAAFVFLIPVTILLVPGAIASGDLAGLVSDFAFYAIFSALISTALSKIMFAAGGMMQASDAMGRIDEILSAPQISVPQDPQVPADNSIEFRNVGFAYEGAIRDALDQVSFTVPAGSTVALVGPSGGGKTTAASLIPRFWDADVGSVLVGGVDVRKVDPRLLMDQVAFVFQNNRLFKTTILENVRAARPEATREEAMEALFAAQCSDIIEKLPEGADTVIGTHGTYLSGGEQQRIALARAILKDAPIVVLDEATAFADPENEVLIQKAFARLAQGRTVVMIAHRLSTVVNADNIVVLDEGRVVEQGTHAELAAAGGLYARMWADYQKAVSWRISKEVA
>NZ_CP012069.2|WP_050340590.1|1814279_1816022_-|ABC-transporter-ATP-binding-protein
MFGKAFKRRFALTDRGVANVKKGTFWTVIVNFVDFAGIGLLFVLTRQLMAMLLDGAPAPTLGYGVGAVIVFLIVSFAAHKMQYKNTYGTVYGEVGRLRVSLAERLRKLPLSFFGGRDLADLSETIMSDADRLEHVWSHVLGYLYGSYISTAVVAVALIAFDWRLGIAVMWGVPVAFGLLFGLRRYNTKSMARARADALVVSDGIQEMLDNAREIRATNQVERHLGELEDKIDAAERSMAASELRVGLVVNAASVIMRLGVATTVVIGVSLLLAGQVDFMVFFMYLLTVSRIYAPFDQALALIAELFLSELSAGRLQVIYDEPVATGADSFDPVGHDIVFDNVSFSYKDEPVLENVSFTAKEGEVTALVGPSGSGKSTCARLAARLWDASFGTIRVGGVDVTSVDPERLLADYAMVFQDVTLFDDSVLANIRLGRKDATDEEVLAAAKAANCDEFVDKLADGYQTMIGENGSRLSGGERQRISIARALLKDAPIVLMDEATASLDVESETKVQEALTRLLAGKTVLVIAHRMRTVENADKIVVLKDGRVVEEGMPDELRAREGGIFRHMAELQQHSAGWAI
>NZ_CP012069.2|WP_050340589.1|1812880_1814083_-|ATP-binding-protein
MIERLIKGRLLELAGKYPIVSVTGPRQSGKTTLVRDAFPDYEYLSFENPDVHRSFDEDPKSFLLRYDSQVIFDEAQRVPDLFSYLQGVVDESGAAGRFILTGSQNFLLMDAVSQSLAGRVALLTLLPLSYEELSQAGIAPQSMEQWLFQGGYPRLYDADIDPETFFPSYVQTYLERDVRRELGVRRLREFSIFIQLCALRTGQRLNVSSLASDSGVALNTAKSWLSVLEASHIICFLEPYFSNRGKSLVKTKKLHFLDAGLACSLIGIQSPQELLVSEHRGPIFESAIISEILKSGYAKARVPHLSFWRDVAQHEVDLVVQRGLRPCYAIEIKSSATYAPRLFTVLNQVAADELGLPIESQAVVYGGDLSLGTRQGQLISYKDVAAAADGWWTARPGAKP
>NZ_CP012069.2|WP_050340588.1|1811258_1812173_-|Abi-family-protein
MRYQKPWLSYEEQADRLEERGLEFDRNDLISHLADVGYYRLSGYWYIYKQNPGSGDESFVEGTSFEKIWDLYTFDRQLRLVTLDAIERVEVYMRTQLAYRLAKTAGPFGYLDRSTLPNMEQSAYGHFMSRCSAAYGRSKALFIEHFKQKYGDLHRLPSYWMLVNIMDFGMMLTLFKGSLDDVRKGIADEMGVPAEVLESWLLTLNTVRNACAHHDRLWNKRLGNKTKIPRSHRCPEWHRPHKVNNRSTFALLTILGYLLERIAPVSSWHDKAVRLIQTRSEEDLCRMGFCKGWETCPMWARWMP
>NZ_CP012069.2|WP_050340587.1|1809777_1810581_+|HAD-family-hydrolase
MSDIKVVAVDMDGTLCRSDTTINEERLRPILARLRAAGCHFVVASGNQYWQLRDFFPSYDEQLAFVAENGSFVKDGPEVVFVGQAQPKAVKVTIGWIHGHSEVRGVMCGVESAYVERGTVTQAWCDRIRTWYHRLRWVDDFSDADDAIIKFFVEVPRERTSGYLGQLSEGLAGLMVPTTSGHGSIDIIIPGCHKASGIERLAKRWDVSADQVIAFGDGSNDVEMLRYAGVGYAMENASGDAKAAADAICPSNDDEGVLQVLERLFPA
>NZ_CP012069.2|WP_172674466.1|1823060_1823678_-|PH-domain-containing-protein
MARQMQLLDDNERELWSGRPNAALYIIGNPLFYVFAALWLLFDLRLFGSFHRTDMSGSGSMASMLTPFFLLHLAPVWLAIGGLIYRACAWHKIQYILTDRRIYQSSGLLGTDVSTLELREVSHLSVNVNPIENALGLGTIRLTPDVSVGSGDNARTVSGYRLRHIKDPYNTYNLIKRVSLDVSTDQQFPNAYRPSENPGYDTRLK
>NZ_CP012069.2|WP_050340597.1|1823838_1824852_-|cobalamin-biosynthesis-protein
MRVLVISGFLGAGKTTFIQELVRRTGKDVVIYENEYGEADVDAQALRADAPDLKVWESVERCICCSGRQDFASSVLTISNTLDPNYLIVEPTGVARLSNVQGNVGSIGYERIGLLPPVCIVDALSWRAQRASARDVFDDQLSCAATVVISKVGERGLDERDTEAAALLSLVARLNPTATIERRPYAQIPRAWWDALLEDPKAADAGRVRDVGGIVSEGDGPATEFETLSLAHARLPSPSQLIWLLDALSSGVFGHIARAKGTLACGGQWVRFDMVERAWAMTGCDEIENPACVFIGTQLRRLWLREAFVPALWRDRAEIVHDHPRDGHDNAHDAHDR
>NZ_CP012069.2|WP_050340598.1|1824921_1825980_-|NAD(P)-dependent-alcohol-dehydrogenase
MKGYAMLKIGESGWIEKEKPTCGPLDAIVKPLAVAICTSDVHTLWEGAIGDRHNMILGHEASGEIVEVGPEVKDFKPGDRVLIPAITPDWNSLEAQAGYSMHSGGMLAGWKFSNFKDGVFSEYFHVNDADGNLAKLPDSIDPADACILSDMVPTGFHAVELADVQFGDTVLVIGIGPVGLMCVAGAALRGASRIIAVGTRPVCVEAAKGYGATDFVSYKDGPIDEQVLKLVGDKGVDRICIAGGTVKTFEPAVKCLKPGGKIGNVNYLGSGDYVNIPRVEWGVGMGHKDIRGGLMPGGRLRMEKLSSLVTAGKLDLHPECTHIFHGWDHIEEALFLMRDKPRDLIKPVVVID
>NZ_CP012069.2|WP_050340599.1|1826373_1827687_-|ATP-binding-protein
MTDDVQGLGAKPAAYVPRIVDAQIDKYLTLFGAIEVSGTKWCGKTWSSLAHAASVTYVDRGSNLQISIADPGYPLAGMRPHVIDEWQRVPAIWDAVRHAVDELAGEKGAWILTGSSTPNKTEVAHSGAGRIGRIRMHPMTLAETGESVSKVSLAGLFCGEFAPCQCPYGIDGLAHMAVRGGWPEERLQTAADAQIVVRDYLESVFVQSVPLLGGNELIARRLSLSLARNLGQSVKVDTLARDVYVRRSDEKVLEAQRKGISAHLDILRRIFLVDEVPGWVPASRSPKRMRVKPKRYFADPSLPVALLGLSPAALLQDWQTFGLVFENLVMRDLDVYARALDLVVASPIRYYHDDSGLEVDAIIERVDGSWAAIEVKVGLDKVDEGVANLMRMRDKVCANKRARAPEPVFMAVITGTGEAAYRRGDGIYVIPIRALGA
>NZ_CP012069.2|WP_050340600.1|1828033_1828420_-|SMI1/KNR4-family-protein
MEFVDWLASQSDVVHGKHATDGQIATAESELGVTFADEYRAYLRSFGSAIVGSHELSGISAAKHVDVVRMTAQERTCNRQVPTELYVLENVGIDGLIVWQDGSGKVYQSLPGAPPSLIARSILEYLNR
>NZ_CP012069.2|WP_050340601.1|1828434_1829664_-|hypothetical-protein
MSRKLPLVLLLTLAMALQGCGGIQPGSTSSDPAPTESEAPGAKDTSSKASKGTTSAPDVEFSGLDDENLQRYLRDTLYTALVEDLDSDQYYVENVDTKYISKEYLKELAANSKENIYFGYTLSALEQQFQGTKYVFTVGDDGHTIVHAFEDYDDTYDRVVQNVAIGTGVILVCITVSAVTGGVAPTVSMVFAVSAKTAAELAVSGGAIGGSMAGISTAIRTGDVSKAIDAAALGGSEGFKWGAIAGAVTGGVGEFSALRGATRNGLTINEAATIQRDAKYPLEIIRRFKNMDEYNIYKEAGLEAKLVNGKSALVRPIDPTIRDGNGLTNIERMKRGLAALDVEGNPYELHHVAQEKDGILAILTKAEHRGEGSFSKLHDLMRGSDVDHGSEWAKEREGFWKSLAETLEK
>NZ_CP012069.2|WP_157051447.1|1829660_1830956_-|hypothetical-protein
MKLKVPSLLTGILLLLLACWVAYPARAEGADSSSQRYSLGEAVNAGLDTGYAENNTIKDGDPHFGWRLGRFSVTGFTSVQRDSADHPTFLKTSGDQITLWFNLEQDINALNGDPILTIFDDENGYDERMQQQREKKGFGRGALFVRQTNYENDQGKPLHYTNYLVGIERGADTQVQLFEEGDYEVALDYEIKKDPRNLLGLSIFPEYHNYTIRFSFSVRNGNAMIFPFDISTGAELTNSSTTDKGFYIDLAKSRYLDVYVKREVLTDSGEWDTRSNEVARDGQQYTDEGVYTITAANPTTGQTTSKKIYVGNNGVLKAYVSTGYSIDQIKDQIAQGASVSDDGSIVWPATSQASEDASAEAPADTGGSQQSTDAADAQVPVGLIAGGLMAFAIVVIFVIVRRKQANILAVGAGAGAARDGVKSQSEGDDAL
>NZ_CP012069.2|WP_050340603.1|1831712_1833206_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MQLILNGIEYTYPGAADPAVLGVSATLPQGWTGLVGDNGCGKTTLARIACGLIKPDAGSVSPRLLSAYCPQSVMVRPEGLEDFAAAYDRDALRLRQNLGIDDGWPWRYGELSGGQRKLVQLACTLWARPDLLVIDEPTNHVDAPTREAIRKALSSFRGVGILISHDRALLDALCSQCLFMRPRETILRPGSYSEGASQEALERETSSRKRDRAVRDRKRLATEAQRLRQRAALADSRRSARKLGKHDSDARAKIHRAILTGQDGKVPALSARMEGRLARAEAIVGSIVVEKTYEGDVWADAMPCKRRVLMHLAAQALPLKDGRLLRIPKLYLGNTDHIALVGRNGTGKTTLVGALLESFPRDIGLTYIPQELDRCQEDELLTRVASRSPADRGFVLSIVARLNSDPSRALEGGASSPGELRKLMLALGILDRTPVIVMDEPTNHLDLRSAEALGKMLKGFPGALLLVSHDERLVASTTTTRWEIMEGDEGELRLRIR
>NZ_CP012069.2|WP_050340604.1|1833230_1834976_-|ABC-transporter-ATP-binding-protein
MYALARRVLDLAGSFSVAARRSLIVGMVCNVLKALFMAPTIVAVFWALEHRDALGPDVIWQCLALLLVSVAGQYAMQYAIDITMDARGFDIFRDLRLRVGDRLKGAAMGYFSEQRLGAIATTLTTTLHQLEEFMTICLTGLSGGLATAAIMGIGFLLMAPPVAAITFMGIVAGLFVLRVLLRRSGAVTKRVLKAQEAMSDAVMEYARGMAVLRSFGTPADALAAAERSFEEKRAADYAQEAAAQGLLKLYALVFNLASCGVLFAACALCLTSALSLPWALTLLVASFMIYGELIAANNGAFLSKKIGNELDRVDEVCDIPKQDSTDEPLAMVGYGVEFDHVSFGYGDGREVIRDVSLRIPEGSSCAIVGPSGSGKTTLVNLIARFWDVDAGRISIGGADVRGGTAESLLARISMVFQDVYLFNDTIESNIRFGVPEATHEQVVAAAEAARCHGFISALPQGYDTVLEEGGASLSGGERQRISIARAILKDAPIVILDEATSSVDPENEHDLIAALSRLTAGKTVISIAHRLNTVATADQILVLDAGRIVQRGRHGQLMEEEGLYRSFIELRRAAAGWTIGG
>NZ_CP012069.2|WP_050340605.1|1834978_1836724_-|ABC-transporter-ATP-binding-protein
MDRGARPSAFAKLYYFMRPDRALMLASLALACLGEVCGMVPYLVVALLAAGLIDNTLTLGHAGLLALAAALAHVVRFVLTWRSSMISHRIAFKALRSMREQMAAKMSRVPLGTIVDTPTGVFRNRFVDNVNMLEDAIAHFMPELPSNVFGPLLAMAIVFSIDWRMGLAGLATLPLGALFFLLMMRGYQEKMARYIATENHMNSTLVEYVNGIKVIKAFGRSASSYGAFSKAVAAYHDSTLDWFRQSWVWMAAIKSVVPCTLLASLPVGIWLMSTGELALPAFMCCIAIPLGFIGPLMKFAQAAGMVSRMDVCLNTIWDFLGEPELVRPQKRVKLNGRSLEFDRVSFSYHEGTRVLHDLSFTVVPGTITAIVGPSGSGKSTIAKLMAGFWDVTEGAIRFGGVDVRDIPFAQLMENVSYVAQDTFLFDRSLADNIRMGRKDASDEEVMAAARAAGCHDFIEALPQGYETLAGAAGGRLSGGERQRVTIARAILKDAPIVVLDEATAYADPENETLVERAVGRLVEGKTLVVIAHRLSTIRHAQQILVVDGGRIVARGTHGELLATGGLYARMWSQHMSTIEEV

Crispr_ID: NZ_CP012069_20

• CRISPR_ID: NZ_CP012069_20
• CRISPR_location: 1937481-1937566
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_20

Consensus_repeat	Method
CCCCGCAGGCTGGCGGGGGGTTGC	CRISPRCasFinder

spacers of NZ_CP012069_20

>20.1|1937505|38|NZ_CP012069|CRISPRCasFinder
TCGAGCGCGTTTGCCCAGTTGGGCCATTTTCCATAGTG

CRISPR arrays and Neighbor proteins around NZ_CP012069_20

CRISPR arrays

The CRISPR arrays of NZ_CP012069_20

>merge|NZ_CP012069|20|1937481-1937566|CRISPRCasFinder
CCCCGCAGGCTGGCGGGGGGTTGCTCGAGCGCGTTTGCCCAGTTGGGCCATTTTCCATAGTGCCCCGCAGGCTGGCGGGGGGTTGC

>NZ_CP012069|20|17|1937481-1937566|CRISPRCasFinder
CCCCGCAGGCTGGCGGGGGGTTGC	TCGAGCGCGTTTGCCCAGTTGGGCCATTTTCCATAGTG
CCCCGCAGGCTGGCGGGGGGTTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050340681.1|1935963_1936785_-|hydroxyethylthiazole-kinase	unknown	unknown	gnl|CDD|236477
NZ_CP012069.2|WP_050340677.1|1932354_1933665_-|phosphomethylpyrimidine-synthase-ThiC	unknown	unknown	gnl|CDD|376689
NZ_CP012069.2|WP_050344505.1|1941638_1942679_+|galactose-mutarotase	unknown	unknown	gnl|CDD|185696
NZ_CP012069.2|WP_050340678.1|1933705_1934524_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl|CDD|180561
NZ_CP012069.2|WP_050340686.1|1943170_1943626_-|DIP1984-family-protein	unknown	unknown	gnl|CDD|213403
NZ_CP012069.2|WP_050340676.1|1931307_1932153_+|metal-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|224381
NZ_CP012069.2|WP_050340683.1|1938035_1938998_-|YitT-family-protein	unknown	unknown	gnl|CDD|224203
NZ_CP012069.2|WP_157051460.1|1929329_1929479_+|hypothetical-protein	unknown	unknown	gnl|CDD|369013
NZ_CP012069.2|WP_050340684.1|1939171_1940011_-|HAD-family-phosphatase	unknown	unknown	gnl|CDD|223635
NZ_CP012069.2|WP_050340688.1|1945713_1946397_-|hypothetical-protein	unknown	unknown	gnl|CDD|225917
NZ_CP012069.2|WP_050340679.1|1934520_1935267_-|HAD-IA-family-hydrolase	unknown	unknown	gnl|CDD|223710
NZ_CP012069.2|WP_050340685.1|1940160_1941339_-|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP012069.2|WP_050340687.1|1944142_1945261_+|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	unknown	unknown	gnl|CDD|180601
NZ_CP012069.2|WP_050340674.1|1929815_1930565_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|236863
NZ_CP012069.2|WP_157051463.1|1947381_1947867_-|DUF4355-domain-containing-protein	unknown	unknown	gnl|CDD|372987
NZ_CP012069.2|WP_050340682.1|1936962_1937157_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340680.1|1935263_1935977_-|thiamine-phosphate-synthase	unknown	unknown	gnl|CDD|238317
NZ_CP012069.2|WP_050340675.1|1930557_1931232_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224922
NZ_CP012069.2|WP_050340691.1|1948062_1948311_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340689.1|1946825_1947341_-|hypothetical-protein	unknown	unknown	gnl|CDD|259835

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050340681.1|1935963_1936785_-|hydroxyethylthiazole-kinase	gnl|CDD|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	2.39794e-98
NZ_CP012069.2|WP_050340677.1|1932354_1933665_-|phosphomethylpyrimidine-synthase-ThiC	gnl|CDD|376689	pfam01964, ThiC_Rad_SAM, Radical SAM ThiC family. ThiC is found within the thiamine biosynthesis operon. ThiC is involved in pyrimidine biosynthesis. ThiC participates in the formation of 4-Amino-5-hydroxymethyl-2-methylpyrimidine from AIR, an intermediate in the de novo pyrimidine biosynthesis. Thic is a member of the radical SAM superfamily.	0
NZ_CP012069.2|WP_050340678.1|1933705_1934524_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl|CDD|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	4.33196e-122
NZ_CP012069.2|WP_050340686.1|1943170_1943626_-|DIP1984-family-protein	gnl|CDD|213403	cd12208, septicolysin_like, putative septicolysin, cholesterol-dependent cytolysin family and related proteins. This group contains some members identified as septicolysin. While septolysin is poorly characterized, it has been identified as a a cholesterol-dependent cytolysin, and acts to facilitate the infection of certain pathogenic bacteria to cells. Cholesterol-dependent cytolysins are pore-forming toxins that aid in bacterial pathogenesis of various gram positive species. Pores are formed by oligomerization into ring-like structures. Related proteins in eukaryotic immune systems use this pore-forming mechanism.	4.17573e-58
NZ_CP012069.2|WP_050340676.1|1931307_1932153_+|metal-ABC-transporter-substrate-binding-protein	gnl|CDD|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	2.0781e-96
NZ_CP012069.2|WP_050340683.1|1938035_1938998_-|YitT-family-protein	gnl|CDD|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	1.2814e-39
NZ_CP012069.2|WP_157051460.1|1929329_1929479_+|hypothetical-protein	gnl|CDD|369013	pfam06637, PV-1, PV-1 protein (PLVAP). This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms. The function of this family is unknown.	0.00289154
NZ_CP012069.2|WP_050340684.1|1939171_1940011_-|HAD-family-phosphatase	gnl|CDD|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	3.30764e-41
NZ_CP012069.2|WP_050340688.1|1945713_1946397_-|hypothetical-protein	gnl|CDD|225917	COG3382, COG3382, Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only].	3.29022e-30
NZ_CP012069.2|WP_050340679.1|1934520_1935267_-|HAD-IA-family-hydrolase	gnl|CDD|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	7.84853e-19
NZ_CP012069.2|WP_050340685.1|1940160_1941339_-|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.03459e-06
NZ_CP012069.2|WP_050340687.1|1944142_1945261_+|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	gnl|CDD|180601	PRK06520, PRK06520, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.	7.85844e-142
NZ_CP012069.2|WP_050340674.1|1929815_1930565_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|236863	PRK11153, metN, DL-methionine transporter ATP-binding subunit; Provisional.	4.03613e-135
NZ_CP012069.2|WP_157051463.1|1947381_1947867_-|DUF4355-domain-containing-protein	gnl|CDD|372987	pfam14265, DUF4355, Domain of unknown function (DUF4355). This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 180 and 214 amino acids in length.	0.000232097
NZ_CP012069.2|WP_050344505.1|1941638_1942679_+|galactose-mutarotase	gnl|CDD|185696	cd09019, galactose_mutarotase_like, galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.	1.86456e-134
NZ_CP012069.2|WP_050340680.1|1935263_1935977_-|thiamine-phosphate-synthase	gnl|CDD|238317	cd00564, TMP_TenI, Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl) thiazole phosphate to yield thiamine phosphate. TenI is a enzymatically inactive regulatory protein involved in the regulation of several extracellular enzymes. This superfamily also contains other enzymatically inactive proteins with unknown functions.	2.8508e-74
NZ_CP012069.2|WP_050340675.1|1930557_1931232_+|ABC-transporter-permease	gnl|CDD|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	8.01006e-85
NZ_CP012069.2|WP_050340689.1|1946825_1947341_-|hypothetical-protein	gnl|CDD|259835	cd13442, CDI_toxin_Bp1026b_like, Mg-dependent tRNAse of the contact-dependent growth inhibition (CDI) system of Burkholderia pseudomallei 1026b, and related proteins. CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the C-terminal toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered. A wide variety of C-terminal toxin domains appear to exist; this particular example from Burkholderia pseudomallei 1026b and other bacteria appears to function as a Mg2+-dependent RNAse cleaving tRNA, most likely in the aminoacyl acceptor stem.	1.11095e-07

Protein sequences

>NZ_CP012069.2|WP_050340682.1|1936962_1937157_-|hypothetical-protein
MSICPEGYMPRVVDAEVQECLAIYGAVEICGNGLALSAHAHKELAVPLVTGAELTLHLLCYNCS
>NZ_CP012069.2|WP_050340681.1|1935963_1936785_-|hydroxyethylthiazole-kinase
MLSDRLRTVRKTTPLVHNITNYVTINDVANAVLACGGSPIMADEPEDVEDITTICGGLNINIGNLNSQTIEAMRIAGRRSRELGHVRVLDPVAAGASKLRTRIASELVDTIGFDAIRGNVSELKALALGSATTRGVDASAADAVTDARLDEMVSFSKGYARKVEGIVAITGAIDLVADEETCYVIRNGRAEMGRVTGTGCMLSGVLCAYLIANPKDKLEAAAAAVCLMGLAGEVGWSRMQEGDGNATYRNRIIDAIYNIDGEQLDREARYELR
>NZ_CP012069.2|WP_050340680.1|1935263_1935977_-|thiamine-phosphate-synthase
MSFDRRSGTAAAAGGPAGRLDREKLAHSLALYAVTDRHWLGERTLDSCVREALRGGATFIQVREKDDMALPHDEYLVEARELRGLCRSQAVPFVVDDDVALALACEADGVHVGQGDMEAAAVRRHIGEGRILGVSAGTVGEARAAERAGADYLGVGAVFPTGSKADADVISREELSAICEAVSIPVVAIGGITAANVGELAGTGICGVAVISAIFAQPDVEAATRELRARIREVLGV
>NZ_CP012069.2|WP_050340679.1|1934520_1935267_-|HAD-IA-family-hydrolase
MIHEAREVCAVRGAHEAFGVRKVRGVAFDIDGTLLDSTGIWDGLAGRYLASIGVRAGPDLAERLFTLTLDEGVAYMKERYGLSQSPEQVRQGISAILEGFYREEVHLKLGAREFVLGLREAEVHMLLTTAGDPALGRLALERLGVWDCFECLLSCDDYATTKAQSKIYRMAAEHLGLPAQDVLVVEDTLLALRCAHEAGFPTCAVQDEASAADQDAIRATVDVYLGSFQEGAAIVSAIGKSPRKGGTR
>NZ_CP012069.2|WP_050340678.1|1933705_1934524_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MKTALTIAGSDSSGGAGIQADIKTMTLNGVFAMSAITALTAQNTMGVTAIMDVTPEFLAAQIDAVFADIRPDAVKIGMVSSPALVFTIADRLRRHEARNVVLDPVMVATSGARLIDDAAVAVLEERLIPLADVITPNIPEAEVLSGLRIKTAADLLAAAEGIATRFGCAVLCKGGHGLSDTDADDLLWSCGSAHWLRARRIDNPNTHGTGCTLSSAIASNLAKGFDLTQATRRAKSYVTDALLAMLDLGQGSGPMNHAFALTGGYAEGPVGG
>NZ_CP012069.2|WP_050340677.1|1932354_1933665_-|phosphomethylpyrimidine-synthase-ThiC
MEELDTQMGAARKGTITPQMEVVAKKERRTVEEIRAWVAEGKVIIPANHAHACLDPNGVGSMLRTKINVNLGVSRDVKDYDIEMEKVKSAVKLGAQAIMDLSSHGDTQPFRRKLCRECPTMVGTVPVYDAVIHYQRDLATLSADDFVDVVRLHAEDGVDFVTLHCGITRKTIDEIRAGGRKMNVVSRGGSLVFAWMAMTGEENPFLERYDDILTICHEHDVTISLGDACRPGCLADATDGCQMGELLRLGELTQRAWDRDVQVMVEGPGHVPMDQIAANMKVQQTICKGAPFYVLGPLVTDIAPGYDHITAAIGGAIAAWAGAAFLCYVTPAEHLALPNVDDVRQGIIASRIAAHAADIAKGIPGSQEPDERMADARRVLDWDAQFKEALDPKVARAIRDSRAPEDDHSETCSMCGKFCAVRSMNKVLAGEYIDIL
>NZ_CP012069.2|WP_050340676.1|1931307_1932153_+|metal-ABC-transporter-substrate-binding-protein
MPDITRRSFILTAAAASSAILLGSALTGCDSTGANGPGAAKRLTVAASPTPHAKILSEFAAPKLKDQGIELTVKEYTDYIIPNQVTSSGEVDVNYFQHINYLDNYNEKNGTDLVGVAAIHYEPFGIYAGTSSDLLSIADGAQIAVPNDPTNEGRALLLLQQEKIIRLSNPNDLEATATSVADNPHNVRLVEVEAAAVPRQLQDVNFAVINGNYAIEAGMHASDALAVESAQGVAVQQYANYIVTTPDKKDDERIAALVKVLTSDDFKKYLSDAYGKDVLPV
>NZ_CP012069.2|WP_050340675.1|1930557_1931232_+|ABC-transporter-permease
MTDAILSFLRDFGTLLGQGIADTLAMLFVSTAIAYVLGIALGVVLYVSAPGSLRPMRALYSVLGWIVNMARSIPFIILIVSVIPMTKAIAGTTVGVRGVIFPLVLSAAPFVARMIEQSLAEVPHNSIEAAEACGASLPRVVFSALLPEALPSIVRGVAVTLISVLGYTAIAGAVGAGGLGDIAIRYGYYRYQDEVMLVTIVLLIALVQLIQTSCDLIARHIDHR
>NZ_CP012069.2|WP_050340674.1|1929815_1930565_+|ATP-binding-cassette-domain-containing-protein
MISLQHLTKTYDASASGDHALRDVSLDIPDGDVFGVIGISGAGKSTLVRCINLLERPTSGRIVVDGSDVTELEGAELRRYRRRVAMIFQDFGLLAQKTALENVCFPFKASTGRVTADNRRRALELLDQVGLADKASSWPAQLSGGQQQRVAIARALACEPEYILCDEATSALDPASTASVLSLLKRINDTAGVTIVIITHSMDVVRQVCKSVAVLSHGKLVERGSVDEVFSNPQNETTKALLGRVSWND
>NZ_CP012069.2|WP_157051460.1|1929329_1929479_+|hypothetical-protein
MKKRITIIVVVILLLLVAFVVFNNAVLSWSSNEGATRRDATGLIHLIHE
>NZ_CP012069.2|WP_050340683.1|1938035_1938998_-|YitT-family-protein
MDDELIDKALGLGRYAGVRRVITGCSVVVSAFLQAFTLIVFIRPADLLSSGFTGLAILLDRITSLLGISFPTFVGMITLNIPVAILCWRHISRRFVLFSMAQVFLAAFFLRVLPPDVLTGLVSFESKFLDVVFGGFLYGFSIALALKGGASTAGSDFISLMVSNRTGKTIWGQIFAGNCVMLLVFGAMFGWENAAWSIIFQFISTNAISMFYHRYERVTLQVTTRRPMEIMAAYQARYRHGVSCVEGFGGYRHQKMWLLNTVVSAYEQDDIIRLMRAVEPHAVINVLRTENFFGGFYRGNIDEPLPQELARDEGTVSGKK
>NZ_CP012069.2|WP_050340684.1|1939171_1940011_-|HAD-family-phosphatase
MVKLVLTDMDNTLLAPGRQASDRALSAIHALVDQGVYFGPASGRDYASVLESFRGDEACMQTALLSNGKKIYVGGVLTNQTAVDRDSMVLMAKIVHDLPGVYVSGRGDAGGFVCARDMESLMGTTWGGRRASELVDPDDIPTWPIITAGLHFEEGSEGIDNNQWADRIRAACPKLDLLSPGSRMFDVVPHGWSKASGVRVLQILLAVNADQIVAFGDSDNDLQMLKVSGHSVAVANANDAVRDVSVHHIGPCTDDAVGRALEQLAEMGDAAFRLWDEKA
>NZ_CP012069.2|WP_050340685.1|1940160_1941339_-|LacI-family-DNA-binding-transcriptional-regulator
MAQVLSRRGFVRRAGAVAAGLGASALLPACSIAPSGGGAAFSDGRMRIGVSIWSATDALGSLTINIIQRAADALGCSLAIVETKHVSKQVIASVSTLISEGCTGVMVCNSADSEMPHLIKACNKNSVYLTQFYRAISQEDSPQVYQAALDSPYYVGAVHEDEVRNGETLAGLLIDGGRRHICLEGWTEKDATFELRWRGYRNARDQWNATHEADRIELSEPIYVGVSASESASAVQRFEGDVPSMDALIVSGGGGVPLVGAIGQLKNMGLTGKVAVATTDFLDNMGEHLSDGSVYCATGGNFCDALYAFILTYQACTGKLQVSQGGDVVNILVPYVRATNASEYAAYKAAFLDEDPYSTDEMRHMAELTPGQLAELAASLSIEEIRARHGRA
>NZ_CP012069.2|WP_050344505.1|1941638_1942679_+|galactose-mutarotase
MSVHIRNFGMTADSKEVHLYTLESVSGMRVSVTDLGGMLQEVSVPDGKGGFIDVALGYDGASGYLRFGGSLGAIIGRNANRIAGASFDLGGTTHRLANNDGENNIHSGPHVWRKRLWDVTEDPKDDPDGGASITFGLVSRDGDQGFPGAADVRATYILHPDWRLELALEAQVTKTTIVNLTSHAYWNLNGHASGSVLRHSFSLDADAYTPVGKGLIPTGEIAPVEGTPYDLRESTNFENRLYALPDGLDTNFVLKNDERLEKVATLVGDETGVSMDLYTDAPGLQVYTGCGLKARGKGGAHYKAFDGVALEPQFFPDAIHHKNFPQPIYAPGHPFVSRMVFAFGLR
>NZ_CP012069.2|WP_050340686.1|1943170_1943626_-|DIP1984-family-protein
MKLAEALQERADLNKKISQIGERLADNCFVQEGERPAEEPARLLDELEAAVSRLELLIAAINATNNVTKVNGRTLTETIARKDCLILRINTLEQLISKASASVTRYTRREIKLMRTVDVSALRERTDALAKELRLLDNSLQEANWQTELVL
>NZ_CP012069.2|WP_050340687.1|1944142_1945261_+|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase
MATLHAPFRYDYVGSFLRPEALKKARADFETDAISATELATVENDAIEDLVAKQKAAGYHVITDGEFRRSYWHLDFMWGLGGIEHIELDHGYQFHSEETTHGSARVTGRITGENHPFVQHYAFVKQFEEEGVIAKQTIPSPAQTLAELFREDNGNETTRVYPKLDELITDIATAYRQVISDLYAAGCRTIQLDDCTWGMIADSSFWKAMAGSGFTLEDEAEKYLRINNLAIEGKPDDLVINTHICRGNYHSDYACTGPYDAVAPYVFAQENVDALYLEYDDERSGGFEPLAQVSPGKKVVLGLITTKSPTLEDKDSVIRRIREAEQYVPLDRLYLSPQCGFASCEIGNKLTEDEQWAKLALVKEIAEEVWGC
>NZ_CP012069.2|WP_050340688.1|1945713_1946397_-|hypothetical-protein
MRFHIDKSMAALGIQHVVVGIARNVDPGATLSDSFLKKQREMEDWALRCDVDEVSSHPVIQGYKNLLQRVGRSVKRNPPTVPALIRNVQHRGSLPRINSVIDIYNVESLRSLLAIGGHDLDKVHGQIEFTVNKEEGTFLPILSKAKHVAKTDYVYRDTEGIMAWLDVRDGENYKFADETQNAVFIIQGNANTSVEMRLDALGRIQADLSECMPAMEFEMQVIHAEEC
>NZ_CP012069.2|WP_050340689.1|1946825_1947341_-|hypothetical-protein
MRRVLADAVRSECDGIESDFKRVWGSYKVTGKSRRGYDETVNAYLASISDGRVSAEYRAKPEAKEIQAAVWLSSGGDPVRFNRESSAPGSKNPDLTIDGKLWEVKRIETSSLAKAKKRVGSGLSQSQRVIVDLSLETLEKDDEKALVGFVSRLRDVRGLIVLHHRYMERVK
>NZ_CP012069.2|WP_157051463.1|1947381_1947867_-|DUF4355-domain-containing-protein
MAGGQGRNRWQNSRDSNRAGVDGSGDAAQAQQADRGKHLRHFDANVDEAINRKCTKRWEWQEAKVTEAAKLEEMGATQKVKYGRERLQEELAELAREGFGKYRVVLVGDERSREACSALVGWVFSIDGAGWGNPAAATSRLPLPDGAAVDDLGARARPGKP
>NZ_CP012069.2|WP_050340691.1|1948062_1948311_-|hypothetical-protein
MRKVVRRAACSSYARVAGYGFIARERLWCTELDRWVDADDGCTFGECGESRARIVQHLREEGVERPPSPTWTCARARPGTST

Crispr_ID: NZ_CP012069_21

• CRISPR_ID: NZ_CP012069_21
• CRISPR_location: 1955102-1955812
• CRISPR_type: TypeI
• Repeat_type: NA
• Spacer_info: 10 spacers
• Cas_protein_info: cas2,cas1,cas4,cas7,cas8c,cas5

Consensus repeat of NZ_CP012069_21

Consensus_repeat	Method
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CRISPRCasFinder
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CRT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	PILER-CR

spacers of NZ_CP012069_21

>21.1|1955135|34|NZ_CP012069|CRISPRCasFinder,CRT
GGCCAGGTGGCGCCGCCTGTGAGCTACAGCTGAG
>21.2|1955202|34|NZ_CP012069|CRISPRCasFinder,CRT,PILER-CR
ATGCCGAGATACCTGCGCTCCAGACGGATCCCGA
>21.3|1955269|36|NZ_CP012069|CRISPRCasFinder,CRT,PILER-CR
CTGGTACGAGGTAGTCATGTTGCAGTAGCTAGCTTC
>21.4|1955338|35|NZ_CP012069|CRISPRCasFinder,CRT,PILER-CR
CTCTCAGTATCGTCTATCTCGGGATGCGCGACCTC
>21.5|1955406|35|NZ_CP012069|CRISPRCasFinder,CRT,PILER-CR
TTGACCTGCCACTTGTTGGCCATTGGGAGTTGACT
>21.6|1955474|36|NZ_CP012069|CRISPRCasFinder,CRT,PILER-CR
CCGGATCGTCCGGCAGCACGCGCACCGCTAGCGCGA
>21.7|1955543|35|NZ_CP012069|CRISPRCasFinder,CRT,PILER-CR
CGCGATTAGCTCATCGCCCATCACGAGATCACTCG
>21.8|1955611|34|NZ_CP012069|CRISPRCasFinder,CRT,PILER-CR
GGCTGGAGGAGCTACCAGAGCTTTTATCGGTCAA
>21.9|1955678|35|NZ_CP012069|CRISPRCasFinder,CRT,PILER-CR
TTTGTAGTCTCCGTATCGTAGGAGCACACAATCTC
>21.10|1955746|34|NZ_CP012069|CRISPRCasFinder,CRT
CCTCTGCGCTTGTCATGTTATGTATCCTAGCCGT

CRISPR arrays and Neighbor proteins around NZ_CP012069_21

CRISPR arrays

The CRISPR arrays of NZ_CP012069_21

>merge|NZ_CP012069|21|1955102-1955812|CRISPRCasFinder,CRT,PILER-CR
GATCTTCCCCACGCGCCCCGTGCGGGGCGCGACGGCCAGGTGGCGCCGCCTGTGAGCTACAGCTGAGGTTTCAATCCACGCGTCCCGCACGGGGCGCGACATGCCGAGATACCTGCGCTCCAGACGGATCCCGAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCTGGTACGAGGTAGTCATGTTGCAGTAGCTAGCTTCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCTCTCAGTATCGTCTATCTCGGGATGCGCGACCTCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACTTGACCTGCCACTTGTTGGCCATTGGGAGTTGACTGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCCGGATCGTCCGGCAGCACGCGCACCGCTAGCGCGAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCGCGATTAGCTCATCGCCCATCACGAGATCACTCGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGGCTGGAGGAGCTACCAGAGCTTTTATCGGTCAAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACTTTGTAGTCTCCGTATCGTAGGAGCACACAATCTCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCCTCTGCGCTTGTCATGTTATGTATCCTAGCCGTGTTTCAATCCACGCGCCCCGCACGGGGTGCGTA

>NZ_CP012069|21|18|1955102-1955812|CRISPRCasFinder
GATCTTCCCCACGCGCCCCGTGCGGGGCGCGAC	GGCCAGGTGGCGCCGCCTGTGAGCTACAGCTGAG
GTTTCAATCCACGCGTCCCGCACGGGGCGCGAC	ATGCCGAGATACCTGCGCTCCAGACGGATCCCGA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTGGTACGAGGTAGTCATGTTGCAGTAGCTAGCTTC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTCTCAGTATCGTCTATCTCGGGATGCGCGACCTC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TTGACCTGCCACTTGTTGGCCATTGGGAGTTGACT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCGGATCGTCCGGCAGCACGCGCACCGCTAGCGCGA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CGCGATTAGCTCATCGCCCATCACGAGATCACTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGCTGGAGGAGCTACCAGAGCTTTTATCGGTCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TTTGTAGTCTCCGTATCGTAGGAGCACACAATCTC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCTCTGCGCTTGTCATGTTATGTATCCTAGCCGT
GTTTCAATCCACGCGCCCCGCACGGGGTGCGTA

>NZ_CP012069|21|2|1955102-1955812|CRT
GATCTTCCCCACGCGCCCCGTGCGGGGCGCGAC	GGCCAGGTGGCGCCGCCTGTGAGCTACAGCTGAG
GTTTCAATCCACGCGTCCCGCACGGGGCGCGAC	ATGCCGAGATACCTGCGCTCCAGACGGATCCCGA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTGGTACGAGGTAGTCATGTTGCAGTAGCTAGCTTC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTCTCAGTATCGTCTATCTCGGGATGCGCGACCTC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TTGACCTGCCACTTGTTGGCCATTGGGAGTTGACT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCGGATCGTCCGGCAGCACGCGCACCGCTAGCGCGA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CGCGATTAGCTCATCGCCCATCACGAGATCACTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGCTGGAGGAGCTACCAGAGCTTTTATCGGTCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TTTGTAGTCTCCGTATCGTAGGAGCACACAATCTC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCTCTGCGCTTGTCATGTTATGTATCCTAGCCGT
GTTTCAATCCACGCGCCCCGCACGGGGTGCGTA

>NZ_CP012069|21|3|1955169-1955745|PILER-CR
GTTTCAATCCACGCGTCCCGCACGGGGCGCGAC	ATGCCGAGATACCTGCGCTCCAGACGGATCCCGA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTGGTACGAGGTAGTCATGTTGCAGTAGCTAGCTTC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTCTCAGTATCGTCTATCTCGGGATGCGCGACCTC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TTGACCTGCCACTTGTTGGCCATTGGGAGTTGACT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCGGATCGTCCGGCAGCACGCGCACCGCTAGCGCGA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CGCGATTAGCTCATCGCCCATCACGAGATCACTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGCTGGAGGAGCTACCAGAGCTTTTATCGGTCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TTTGTAGTCTCCGTATCGTAGGAGCACACAATCTC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_062393126.1|1965910_1966828_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl|CDD|377458
NZ_CP012069.2|WP_050340701.1|1957664_1958858_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271188
NZ_CP012069.2|WP_050340698.1|1954127_1954355_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_062393124.1|1948941_1949355_-|minor-capsid-protein	unknown	unknown	gnl|CDD|213641
NZ_CP012069.2|WP_050340700.1|1955952_1957449_+|IS21-family-transposase	unknown	unknown	gnl|CDD|226950
NZ_CP012069.2|WP_157051465.1|1954622_1954799_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051464.1|1950434_1951049_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340708.1|1968675_1969359_-|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl|CDD|187534
NZ_CP012069.2|WP_050340707.1|1966837_1968679_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl|CDD|378245
NZ_CP012069.2|WP_050340695.1|1949878_1950517_+|phage-portal-protein	unknown	unknown	gnl|CDD|377413
NZ_CP012069.2|WP_157051589.1|1949665_1949839_+|HK97-family-phage-prohead-protease	unknown	unknown	gnl|CDD|273682
NZ_CP012069.2|WP_050340698.1|1951817_1952045_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340699.1|1952298_1954059_+|IS1634-family-transposase	unknown	unknown	gnl|CDD|227708
NZ_CP012069.2|WP_050340692.1|1948394_1948829_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340706.1|1965268_1965901_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|273040
NZ_CP012069.2|WP_050340703.1|1959795_1960782_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271183
NZ_CP012069.2|WP_050340705.1|1964252_1965272_-|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl|CDD|188360
NZ_CP012069.2|WP_050340697.1|1951009_1951717_+|hypothetical-protein	unknown	unknown	gnl|CDD|259835
NZ_CP012069.2|WP_083443905.1|1958848_1959799_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271178
NZ_CP012069.2|WP_050340704.1|1963959_1964250_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP012069.2|WP_062393126.1|1965910_1966828_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	3.8e-114	375.3	0.0
NZ_CP012069.2|WP_050340706.1|1965268_1965901_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	1.9e-33	110.6	0.0
NZ_CP012069.2|WP_050340707.1|1966837_1968679_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	3.2e-137	453.1	0.0
NZ_CP012069.2|WP_050340705.1|1964252_1965272_-|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	6.3e-128	421.3	0.0
NZ_CP012069.2|WP_050340708.1|1968675_1969359_-|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	1.7e-81	267.6	0.0
NZ_CP012069.2|WP_050340704.1|1963959_1964250_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.2e-30	100.3	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_062393126.1|1965910_1966828_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	8.04767e-143
NZ_CP012069.2|WP_050340701.1|1957664_1958858_+|tyrosine-type-recombinase/integrase	gnl|CDD|271188	cd01188, INT_RitA_C_like, C-terminal catalytic domain of recombinase RitA, a component of the recombinase trio. Recombinases RitA (also known as pAE1), RitB, and RitC are encoded by three adjacent and overlapping genes. Collectively they are known as the Recombinase in Trio (RIT). This RitA family includes various bacterial integrases and integrases from the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus H1. All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.61829e-57
NZ_CP012069.2|WP_062393124.1|1948941_1949355_-|minor-capsid-protein	gnl|CDD|213641	TIGR01641, Uncharacterized_protein_MJ0329, phage putative head morphogenesis protein, SPP1 gp7 family. This model describes a region of about 110 amino acids found exclusively in phage-related proteins, internally or toward the C-terminus. One member, gp7 of phage SPP1, appears involved in head morphogenesis. [Mobile and extrachromosomal element functions, Prophage functions].	2.34901e-08
NZ_CP012069.2|WP_050340700.1|1955952_1957449_+|IS21-family-transposase	gnl|CDD|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	8.19948e-16
NZ_CP012069.2|WP_050340706.1|1965268_1965901_-|CRISPR-associated-protein-Cas4	gnl|CDD|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	3.98103e-30
NZ_CP012069.2|WP_050340699.1|1952298_1954059_+|IS1634-family-transposase	gnl|CDD|227708	COG5421, COG5421, Transposase [DNA replication, recombination, and repair].	9.66038e-09
NZ_CP012069.2|WP_050340708.1|1968675_1969359_-|type-I-C-CRISPR-associated-protein-Cas5	gnl|CDD|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	1.533e-103
NZ_CP012069.2|WP_050340695.1|1949878_1950517_+|phage-portal-protein	gnl|CDD|377413	pfam04860, Phage_portal, Phage portal protein. Bacteriophage portal proteins form a dodecamer and is located at a five-fold vertex of the viral capsid. The portal complex forms a channel through which the viral DNA is packaged into the capsid, and exits during infection. The portal protein is though to rotate during DNA packaging. Portal proteins from different phage show little sequence homology, so this family does not represent all portal proteins.	1.09487e-28
NZ_CP012069.2|WP_157051589.1|1949665_1949839_+|HK97-family-phage-prohead-protease	gnl|CDD|273682	TIGR01543, Putative_prohead_protease, phage prohead protease, HK97 family. This model describes the prohead protease of HK97 and related phage. It is generally encoded next to the gene for the capsid protein that it processes, and in some cases may be fused to it. This family does not show similarity to the prohead protease of phage T4 (see pfam03420). [Mobile and extrachromosomal element functions, Prophage functions, Protein fate, Other].	1.57467e-07
NZ_CP012069.2|WP_050340703.1|1959795_1960782_+|tyrosine-type-recombinase/integrase	gnl|CDD|271183	cd01182, INT_RitC_C_like, C-terminal catalytic domain of recombinase RitC, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	4.31196e-55
NZ_CP012069.2|WP_083443905.1|1958848_1959799_+|tyrosine-type-recombinase/integrase	gnl|CDD|271178	cd00797, INT_RitB_C_like, C-terminal catalytic domain of recombinase RitB, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	7.41984e-26
NZ_CP012069.2|WP_050340707.1|1966837_1968679_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl|CDD|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NZ_CP012069.2|WP_050340705.1|1964252_1965272_-|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl|CDD|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	3.73193e-156
NZ_CP012069.2|WP_050340697.1|1951009_1951717_+|hypothetical-protein	gnl|CDD|259835	cd13442, CDI_toxin_Bp1026b_like, Mg-dependent tRNAse of the contact-dependent growth inhibition (CDI) system of Burkholderia pseudomallei 1026b, and related proteins. CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the C-terminal toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered. A wide variety of C-terminal toxin domains appear to exist; this particular example from Burkholderia pseudomallei 1026b and other bacteria appears to function as a Mg2+-dependent RNAse cleaving tRNA, most likely in the aminoacyl acceptor stem.	5.89019e-08
NZ_CP012069.2|WP_050340704.1|1963959_1964250_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.15166e-32

Protein sequences

>NZ_CP012069.2|WP_157051465.1|1954622_1954799_+|hypothetical-protein
MQPQCDRVLISNVESGLSFDEMYSWLEDQGDEFPKVREMIIVSRDGRIRHYVRGKPAE
>NZ_CP012069.2|WP_050340698.1|1954127_1954355_+|hypothetical-protein
MPYFKDAATPADVADGGGTVTGYAATFDREPDCYGDVIAPSAGSSPYVGNSSQADVFNDYYARRIASEMGSRDRR
>NZ_CP012069.2|WP_050340699.1|1952298_1954059_+|IS1634-family-transposase
MSYFLKQTRNKKGTYLQIYESTYDPGRGYGTHRSVRAVGYVHELEQSGIPDPVARLRAEVAAMNEEARASRAREGARLVGDSTPERHMGHFPVKALYRRLGIPADIGYLQMASGFRFSLDGLLESLVCARVVAPCSKSRTFHDVLPLLGEEPSFSLGQLYDGISYLGHEYRKVVEAANARVGELFGRDTSRSYFDCTNFYFEIDREDGLRRKGPSKERRADPIVGMGLLLDARCVPMGLEIYPGNESERPRIREVIGALKERHHMTGRTVRVADKGLNCADNVADAVLAGDGYLFSKSVRRLPARELAWVLSEEGWEDHLGRDGRIHHRTKSVTGDFEYRVSREGGGKGTVELRERRVVTFSPRLRSKQLREINRQVEKARRLRLAEARRSEYGDSAKYVTFVAVDSEGEVRDDERVVATLNRKAIGRARSLAGYNMLVTSEADMPEAEVYDTYHRLWRIEETFRVMKSELDARPVYLRRHDSIVGHFLICYVAVLLVRLLQVHVLGDEFGSGQLFGFMRGFRAVRVSERRYVNISRSSPVIDRLKEVTGLPLDHYHLTKGEYDRILGYRFPSLKATGQEESKGSI
>NZ_CP012069.2|WP_050340698.1|1951817_1952045_+|hypothetical-protein
MPYFKDAATPADVADGGGTVTGYAATFDREPDCYGDVIAPSAGSSPYVGNSSQADVFNDYYARRIASEMGSRDRR
>NZ_CP012069.2|WP_050340697.1|1951009_1951717_+|hypothetical-protein
MAGPNARATHAAMNGQRVPIGGRFSNQARWPGDTNLSAAESCDCNCRIEIVSGEGRSKDSRGSKVRKREAGIQRETDKRYREYKSGMNELSERDREARYRRAMGEYVGSFTVEGKVSAKYQAEPWAKELQTTQTLSELGHSVEFLPSTGDGRHPDAMLDGVITDFKRVEAFDPDRVFKLIRKAGSQGAEIVVIDLCLDTVSLDAALEKAAKAVRLGFVEEGHVIVLDWNSEEHVI
>NZ_CP012069.2|WP_157051464.1|1950434_1951049_+|hypothetical-protein
MAKALAGAPGRRHGAGSPRLRARPGEGDVERVEEALEAFYRRQGASLADEALRMGAEDIVLSADADWLDGPRWTDELCDDLFDAMSGLAPAWAADAMTSLGADAGHLDEDAVLAEVRRLSRFRAADIVRSASERVVSDLGDLDELTPRGAIEATTRRLMASGATAGPSRLPPPTARRSRARGSPASSARRSGWRGPTPGRRTRP
>NZ_CP012069.2|WP_050340695.1|1949878_1950517_+|phage-portal-protein
MKYRFSGGEGTDSGGIPILEDSMRFVDSAINDKEAEWAESMRLTREDVAAAYHVNPSIVWSNDGQTYASTRVRECARSLYADTLGPLLRLVQDGIRSKLVPMIGADPRSYAEFDITAKLAGSFEGQASVLSTSTGGPWMTRNEARARQNPPAIEGGDELIVPMNVTEGARLPDGHGPDSGVLGGAHGQGPRRRAWETARGWVTQAEGTPRGG
>NZ_CP012069.2|WP_157051589.1|1949665_1949839_+|HK97-family-phage-prohead-protease
MGYAATFDREPDCYGDVIAPGAFADSLERWGKVGKPIPLLYGHNTQDPRYNIGAVTE
>NZ_CP012069.2|WP_062393124.1|1948941_1949355_-|minor-capsid-protein
MGYGKGFHALDDDTILRFVGTRWASGKSYSEAIWGDSERVAAWVQDDMAKALARGESWRRLCDELSRRFVDVSERDVMRLVVTEGTYVSRQAQLAELAREGFEEYRVEPVGDERTCEVCSALVGKAFSIDGARVGRC
>NZ_CP012069.2|WP_050340692.1|1948394_1948829_-|hypothetical-protein
MNPLHPVPGRGSVRYGKPKERLTGNEQTCVSHLESLGYQVEVLDEDLEKPANIDLRLGESGQLWEMKNVGDGKHAIEDNMRNAYHKWVRLGLDAPNETRVVMTSYGGMRSESEIVDEIRRRMRRYAANVIYIFRDGASSLFLGR
>NZ_CP012069.2|WP_050340700.1|1955952_1957449_+|IS21-family-transposase
MIRHGEILRLTALGISQRSIAGSVGCSKTTVQEVQRKAATRRLEWPLSDEMGDEAIRARPCPPQDRSDASKAEIDHEWARREMGRRGVTMTLLWSEYAERAVAAGRTPYMYSSFCHRHQRWVDANPECAMHVEWVPGEWTQVDWAGDTMRVSDPDASSPSRVHVFVACLPFSAHVYAEGFYRMDERAWVEGHVRAFADFGGSTPLIAPDNLKTGVVRNTIDKLIVNEQYRRMLEYHGSAAVPTRVRRPRDKGGVEGAVLIVEREAIAALRDRTFFSLAEPDQALRERVDAINARPFQRREGSRDEMLLGQERACLQPLPQAPYELVERKSATVQFNYHVAFDGRYYSVPFTHIRRSVEVVATRSTVTVSSDGERLCQHQRSHGPKGTYVTDPAHMPRAHRDFAEWSGERFRRWAAEKGPSTLAVTDVILRSRQVEQQSYRTCRALLSLGAYCSFFGVTFRSPSVYRSISHRCVLACGTGADGAHDRVHTGDFAVLGLT
>NZ_CP012069.2|WP_050340701.1|1957664_1958858_+|tyrosine-type-recombinase/integrase
MMRDLDALASQARGYLVDKGYARSTIAHYEAAWKRLMSWCEDEGIGGYDHDVERRFIEEVVMANADATRYFRLDKSRVLLLLSIDETGEPPDREARRRFVVPAGFDAAYMAYAAELEERGLRASTREGYLCTARNFCEGCGATRPEQLDARSIGVFAEAVSHCAPQTRSAKLYVARDFTRFLARVGACGPEVAAAVPHIPGHKHSTVPSAYSTAEVSTMLESFPRSLRPRRDRAMMLLASVLGMRAGDIKALRLSDIDWRAKTVSFVQRKTQVTNTLHMPEEVWLAVADYIRCERPDVDGDRVFVTACAPYHAIDSSHTFHRTVTRAFADAGVETAGKHHGMHSLRHSAASNMLSGGTPYPTISSVLGHSSANVTKRYLSIDVESLRPLALEVPSCL
>NZ_CP012069.2|WP_083443905.1|1958848_1959799_+|tyrosine-type-recombinase/integrase
MPMRIEFTGEYAALMGGYVAFRQNLGFVMPESSQRWLRHMADLLYTMPLISEVIDMERAEAIASRREGESDVTRQSRFVVLRQFCLYLNRIGVGAYVPPAGQVRARSEFVPRIVSEREMARIIEVAEGKALRWPPMVLKILWCTGIRIGEAAALTVGDFHRKDRSLYVAHAKSDRSRIVPVSESLAVDLGEYVDARVPGGDSCRWLFPGRDPGSHRSKVAIGNRLRGIYREARVLTDEGRPIRTHDIRHSFAIATLEKMVEQGRDVYVTLPLLSAFMGHANICDTEYYLRFLPSAHRALVEQEAPISHAVFGDGAL
>NZ_CP012069.2|WP_050340703.1|1959795_1960782_+|tyrosine-type-recombinase/integrase
MRGFAQLLSGFLLEYVPRRRSLSENTAKSYRDSFAILLRWLADGRGIAPDDVRIEDLSRENVESFCLWLSDVRGVCAATVNVRLCALRSFASYVSFTEPAYLEWASALRAVEFSKSPSGEVEWLPVEAVNLIMESASSDAREHAMLGLLYDSGARVSEIANARRCDLRLDAPATIRLSGKGRKVRIVPLCDQVAGMASAYLAATAGAPDSPLFVNRSGKAIGRAGITYVLKKHVAAAHEADPLVVPPTTHPHALRHSKAVHLVEADVNIIYIRDFMGHSSVKTTEIYAKISSKSRQKAVEKAAANLIMGSAYGEEDKSAIMEWLRNLL
>NZ_CP012069.2|WP_050340704.1|1963959_1964250_-|CRISPR-associated-endonuclease-Cas2
MYVLVTYDVASGDVGGPRRLRRVAKICTQYGQRVQYSVFECLVDPGQYESMKHELARIIDEGRDSLRFYNLGKNWKNRVEHIGAKDSYDPEDLLCI
>NZ_CP012069.2|WP_050340705.1|1964252_1965272_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MKRLLNTLYLTNPDAYLRKKDDALAVYVEQKKVMSVPFHLLEGVVLFGHVGCSTAVLGACATRGISVAILDEGGRFQASVRGPISGNVLLRREQYRRSMDVIECLSAARRFVAAKVHNSRVVLQHYVRDYPDMEGIGAGDAIRELKQSGEEIRRCNNLDELRGIEGNAAHVYYSAIQGALRCDGVTFTGRTRRPPKDPVNSALSFFYTMLSRELMSACESVGLDPQMGYLHACRPGRASLALDFIEEFRAPMVDRFVLSLFNRKQLVASDFLAESQGFLLKDSTRKKVLGYWQQKKQDQLTHPFLGERMPLGLVPFIQAQLFARYLRGDLNDYPAFLWR
>NZ_CP012069.2|WP_050340706.1|1965268_1965901_-|CRISPR-associated-protein-Cas4
MYDEDELLALSGLQHLAYCERQWALIHLEQIWQDSADTLRGDYFHERVDTVGYSCTDGVRSERRVRLVSRSLGIYGVADIVEYGVGDVGSFVRPIEYKVGKPKLEDWDRIQITAQALCLEEMHGLKIPEGALFYGETRRRERVEVTQKLRRKVDSLSLRMHDLFEMGVTPPAERNSKCRRCSLANECMPEAGCVDARSYWVRYGEDLELT
>NZ_CP012069.2|WP_062393126.1|1965910_1966828_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MPEPIQNRYDFVFFCDVKNGNPNGDPDAGNLPRIDPDTSQGIISDVCIKRKIRNYVDLIKGEAIDDPDVNEGELGYKIYVQESAVLNERNRKAYVHYKLIPQAKKLPKKVEDQIKVTKFMCDNFYDIRTFGAVMTTGVNCGQVRGPVQLCFGESIDPVVPLEMSITRMAATEAKEDKDNKTMGRKQYVPYGLYRIEGFVSASLAEKNGFCQADLDLLWEALMNMFENDRSAARGLMTSRELIVFKHESKFGNAPAHRLFDLVHVDKVDSKNQVAREFGDYTITIDEGKLPQGVEIRTYDYIAPSA
>NZ_CP012069.2|WP_050340707.1|1966837_1968679_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MIVKDLYDLYERYAADPQMQDKVPPKGMSREKVEWELVLSESGALVNVIPLSHGDGKGSNRYCVMTVPEHRTRTSGVSPFFLCDTAAYLLGMADISKAKDESEVVKAQRKAQERWEASRDYHLSILSSCDDVAAQAVMGFFSHNILKERENDDLLRDIAESGNLIFALKDSDGNIVPIHESKAIMAAWESSHVSALADEPCIRGQCSVTGKVAPLARLFPQVTGLAGAQSSGASLISFNCDSFNSYGRTQAYNASVSQWVAFGAGTALKMLLSDPERKIRLGATTFTFWSDRPSPDEDSLFIRFFGGGDKNDTAEDSATVTRVRDAIKGIKSGHPLRANFNPDVRYYVLGISPNAARLSVRFFETSTLGEVAERYGQYLRDIDMVDVSTTSIFQLIRQCAVQGKYENLPSTLVNPCMRAMLTGSRFPQSLLSTLLSRMRADHGSNNRWDMGQRASLIKACLVRNLQSTRESEIDVALNRDNNCVGYLLGRLFAVMERAQSEALGTTNATIRDKYIGSASVTPARVMPTLMHGCQNHLSDLRKKKPGLNVILEKELDEIVGRKLSDNPYPGTLSMEDQGEFFIGYYQERVDLWTSRKRDDVAPDEAASNDLSEN
>NZ_CP012069.2|WP_050340708.1|1968675_1969359_-|type-I-C-CRISPR-associated-protein-Cas5
MGYGIRILVKGPRACFTRPEMKAERVSYDVITPSAARGILEAVYWKPAISWCIDSIEVLNEIRFETFRRNEVESKLPYSGKSGAKSIADGKNLPLYEVASEDRQQRATLLLRDVAYIINAHFDLTDRVGEGDTVEKHYNIALRRLRKGQCFNQPYFGCREFAAEVSLLEEGEEASPSFYAGISEKDLGFMLYDLDFTDVRKPEPRFFRAVMKNGVIDVSAALQEVVG

Crispr_ID: NZ_CP012069_22

• CRISPR_ID: NZ_CP012069_22
• CRISPR_location: 1961062-1963790
• CRISPR_type: TypeI
• Repeat_type: NA
• Spacer_info: 40 spacers
• Cas_protein_info: cas2,cas1,cas4,cas7,cas8c,cas5,cas3,PrimPol

Consensus repeat of NZ_CP012069_22

Consensus_repeat	Method
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CRT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CRISPRCasFinder
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	PILER-CR

spacers of NZ_CP012069_22

>22.1|1961095|36|NZ_CP012069|CRT
CATGTATCCCAGGTCTGTGCAGTCATTCAGCTCGTG
>22.2|1961164|35|NZ_CP012069|CRT,CRISPRCasFinder
TTTGCATCCAGGATGTGTTCTCTGATAGTTCCATG
>22.3|1961232|36|NZ_CP012069|CRT,CRISPRCasFinder
TGTAGCTTCGTGATGGCATTTTATCTCCTGATGGTT
>22.4|1961301|34|NZ_CP012069|CRT,CRISPRCasFinder
CGTCTACCTCCCTATATCGTAATACCAGCAGAGC
>22.5|1961368|33|NZ_CP012069|CRT,CRISPRCasFinder
GAATCGACCCTGAGAGCAAACCCAAGCTTAACC
>22.6|1961434|34|NZ_CP012069|CRT,CRISPRCasFinder
GACCGACGTACCCTTAGGACGCGAGCGGACCCAA
>22.7|1961501|34|NZ_CP012069|CRT,CRISPRCasFinder
GGTTAAAGGAGCTTCCCGAGCTGCTGTCGGTTAA
>22.8|1961568|34|NZ_CP012069|CRT,CRISPRCasFinder
GTTCAGAAACTAATCGACCTCGTTACGCAGATGG
>22.9|1961635|34|NZ_CP012069|CRT,CRISPRCasFinder
GCGTCAGGATTCGCGAGATGCGCGCCTTGGCTCG
>22.10|1961702|34|NZ_CP012069|CRT,CRISPRCasFinder
CACCAATGCAAAGCGGGATAAGCTCATAGCTATT
>22.11|1961769|33|NZ_CP012069|CRT,CRISPRCasFinder
TGCCGGCACGAAGTTATCGCGGGCTAAGGACAG
>22.12|1961835|35|NZ_CP012069|CRT,CRISPRCasFinder
TAGCGATGGACGCAAAGTACGACCGGATGGGCAAG
>22.13|1961903|34|NZ_CP012069|CRT,CRISPRCasFinder
CTCCCTTGCTCACACATAAATTGTACCACGGCAC
>22.14|1961970|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GATGACGTACTCGGACCGGAGCCGTGCGTCGCGC
>22.15|1962037|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
TATGGTTATGGCACCTGATGTTTTTACCAAGGCA
>22.16|1962104|35|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
CTCAAGAGACTTACGAGAGAGGTAGGACAGTAGAT
>22.17|1962172|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
AGGGCTGGACCGTGCTGCTCCTCGTGCAGTCCCT
>22.18|1962239|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
CCGTAGATGATATGTGCCTCGTCTATCGCGAGCA
>22.19|1962306|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
CACCCCATCACCATACCGCTACCCCAGCCGAGCA
>22.20|1962373|35|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GCCGTGACCTCGGTCTTGTTGGCATGGACCAGTTG
>22.21|1962441|35|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GTCTTCAAGCAGTTGCGGAGTAAGCCTATCATTCG
>22.22|1962509|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
AGCAGCTCTGGTACATCACGCTCACCCTCTCTCG
>22.23|1962576|35|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
CAGCAAGATATGCGTATGTGGCTTCTTAGGATCAA
>22.24|1962644|36|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GATGCCCAAGCGCAAGACCACTGATGATAGGGCCAA
>22.25|1962713|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GCGTTGAGCATGAGCTGGGCTTCGTCGATGACAA
>22.26|1962780|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GCAAGCATCACGTCACCCCACAGTCAGACCAGCT
>22.27|1962847|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GGCCGGTCAAGAGCAACAAGGGCAAGGCCAAGCG
>22.28|1962914|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
CCCATGGAATTAAGTACACCCATCAACGTAGTAA
>22.29|1962981|36|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GGTTGGCTCTATTTTAACAACTCTAATGGATACCCT
>22.30|1963050|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GCGCGCACAGCGCCAATCACTAGCGGGATTAACT
>22.31|1963117|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
AGGGATACGCGACTGGTCCACCATGACACAGGCA
>22.32|1963184|33|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
CATCTCAGCGCCCAGCACGAGCCGTAAACCTTT
>22.33|1963250|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GCGCCATAGATGATGTGTGCCTCATCTATCGCGA
>22.34|1963317|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
TGACTAATCGGATCCGGAGGCCAGACTGATGCAA
>22.35|1963384|33|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
ATGGCCGGCGAGACTCAGAGCGCGCGCGTTCCC
>22.36|1963450|35|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
AAGCTGCTGACGGCTGGATTCGGTGCGACGGGCCG
>22.37|1963518|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
GGGTGACTCTTTTGTCCTTGTCGTTCTCAAGGCT
>22.38|1963585|35|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
CGAAGCACCGGCGATTGCTTAACTTGACCCTCTGC
>22.39|1963653|35|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
AAGCTGCTGACGGCTGGATTCGGTGCGACGGGCCG
>22.40|1963721|37|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR
CCCATCTACCTGCGCTTTTACCCTCACTGTCCTTCAC

CRISPR arrays and Neighbor proteins around NZ_CP012069_22

CRISPR arrays

The CRISPR arrays of NZ_CP012069_22

>merge|NZ_CP012069|22|1961062-1963790|CRT,CRISPRCasFinder,PILER-CR
CTTGTAGCCTGCTGTACGCACACGGGGCGCGACCATGTATCCCAGGTCTGTGCAGTCATTCAGCTCGTGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACTTTGCATCCAGGATGTGTTCTCTGATAGTTCCATGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACTGTAGCTTCGTGATGGCATTTTATCTCCTGATGGTTGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCGTCTACCTCCCTATATCGTAATACCAGCAGAGCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGAATCGACCCTGAGAGCAAACCCAAGCTTAACCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGACCGACGTACCCTTAGGACGCGAGCGGACCCAAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGGTTAAAGGAGCTTCCCGAGCTGCTGTCGGTTAAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGTTCAGAAACTAATCGACCTCGTTACGCAGATGGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGCGTCAGGATTCGCGAGATGCGCGCCTTGGCTCGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCACCAATGCAAAGCGGGATAAGCTCATAGCTATTGTTTCAATCCACGCGCCCCGCACGGGGCGCGACTGCCGGCACGAAGTTATCGCGGGCTAAGGACAGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACTAGCGATGGACGCAAAGTACGACCGGATGGGCAAGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCTCCCTTGCTCACACATAAATTGTACCACGGCACGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGATGACGTACTCGGACCGGAGCCGTGCGTCGCGCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACTATGGTTATGGCACCTGATGTTTTTACCAAGGCAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCTCAAGAGACTTACGAGAGAGGTAGGACAGTAGATGTTTCAATCCACGCGCCCCGCACGGGGCGCGACAGGGCTGGACCGTGCTGCTCCTCGTGCAGTCCCTGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCCGTAGATGATATGTGCCTCGTCTATCGCGAGCAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCACCCCATCACCATACCGCTACCCCAGCCGAGCAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGCCGTGACCTCGGTCTTGTTGGCATGGACCAGTTGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGTCTTCAAGCAGTTGCGGAGTAAGCCTATCATTCGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACAGCAGCTCTGGTACATCACGCTCACCCTCTCTCGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCAGCAAGATATGCGTATGTGGCTTCTTAGGATCAAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGATGCCCAAGCGCAAGACCACTGATGATAGGGCCAAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGCGTTGAGCATGAGCTGGGCTTCGTCGATGACAAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGCAAGCATCACGTCACCCCACAGTCAGACCAGCTGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGGCCGGTCAAGAGCAACAAGGGCAAGGCCAAGCGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCCCATGGAATTAAGTACACCCATCAACGTAGTAAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGGTTGGCTCTATTTTAACAACTCTAATGGATACCCTGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGCGCGCACAGCGCCAATCACTAGCGGGATTAACTGTTTCAATCCACGCGCCCCGCACGGGGCGCGACAGGGATACGCGACTGGTCCACCATGACACAGGCAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCATCTCAGCGCCCAGCACGAGCCGTAAACCTTTGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGCGCCATAGATGATGTGTGCCTCATCTATCGCGAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACTGACTAATCGGATCCGGAGGCCAGACTGATGCAAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACATGGCCGGCGAGACTCAGAGCGCGCGCGTTCCCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACAAGCTGCTGACGGCTGGATTCGGTGCGACGGGCCGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGGGTGACTCTTTTGTCCTTGTCGTTCTCAAGGCTGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCGAAGCACCGGCGATTGCTTAACTTGACCCTCTGCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACAAGCTGCTGACGGCTGGATTCGGTGCGACGGGCCGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCCCATCTACCTGCGCTTTTACCCTCACTGTCCTTCACGTTTCAATCCACGCGCCCCGCACGGGGCGCGAC

>NZ_CP012069|22|3|1961062-1963790|CRT
CTTGTAGCCTGCTGTACGCACACGGGGCGCGAC	CATGTATCCCAGGTCTGTGCAGTCATTCAGCTCGTG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TTTGCATCCAGGATGTGTTCTCTGATAGTTCCATG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TGTAGCTTCGTGATGGCATTTTATCTCCTGATGGTT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CGTCTACCTCCCTATATCGTAATACCAGCAGAGC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GAATCGACCCTGAGAGCAAACCCAAGCTTAACC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GACCGACGTACCCTTAGGACGCGAGCGGACCCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGTTAAAGGAGCTTCCCGAGCTGCTGTCGGTTAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GTTCAGAAACTAATCGACCTCGTTACGCAGATGG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGTCAGGATTCGCGAGATGCGCGCCTTGGCTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CACCAATGCAAAGCGGGATAAGCTCATAGCTATT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TGCCGGCACGAAGTTATCGCGGGCTAAGGACAG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TAGCGATGGACGCAAAGTACGACCGGATGGGCAAG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTCCCTTGCTCACACATAAATTGTACCACGGCAC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GATGACGTACTCGGACCGGAGCCGTGCGTCGCGC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TATGGTTATGGCACCTGATGTTTTTACCAAGGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTCAAGAGACTTACGAGAGAGGTAGGACAGTAGAT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AGGGCTGGACCGTGCTGCTCCTCGTGCAGTCCCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCGTAGATGATATGTGCCTCGTCTATCGCGAGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CACCCCATCACCATACCGCTACCCCAGCCGAGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCCGTGACCTCGGTCTTGTTGGCATGGACCAGTTG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GTCTTCAAGCAGTTGCGGAGTAAGCCTATCATTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AGCAGCTCTGGTACATCACGCTCACCCTCTCTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CAGCAAGATATGCGTATGTGGCTTCTTAGGATCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GATGCCCAAGCGCAAGACCACTGATGATAGGGCCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGTTGAGCATGAGCTGGGCTTCGTCGATGACAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCAAGCATCACGTCACCCCACAGTCAGACCAGCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGCCGGTCAAGAGCAACAAGGGCAAGGCCAAGCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCCATGGAATTAAGTACACCCATCAACGTAGTAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGTTGGCTCTATTTTAACAACTCTAATGGATACCCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGCGCACAGCGCCAATCACTAGCGGGATTAACT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AGGGATACGCGACTGGTCCACCATGACACAGGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CATCTCAGCGCCCAGCACGAGCCGTAAACCTTT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGCCATAGATGATGTGTGCCTCATCTATCGCGA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TGACTAATCGGATCCGGAGGCCAGACTGATGCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	ATGGCCGGCGAGACTCAGAGCGCGCGCGTTCCC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AAGCTGCTGACGGCTGGATTCGGTGCGACGGGCCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGGTGACTCTTTTGTCCTTGTCGTTCTCAAGGCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CGAAGCACCGGCGATTGCTTAACTTGACCCTCTGC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AAGCTGCTGACGGCTGGATTCGGTGCGACGGGCCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCCATCTACCTGCGCTTTTACCCTCACTGTCCTTCAC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC

>NZ_CP012069|22|19|1961131-1963790|CRISPRCasFinder
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TTTGCATCCAGGATGTGTTCTCTGATAGTTCCATG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TGTAGCTTCGTGATGGCATTTTATCTCCTGATGGTT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CGTCTACCTCCCTATATCGTAATACCAGCAGAGC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GAATCGACCCTGAGAGCAAACCCAAGCTTAACC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GACCGACGTACCCTTAGGACGCGAGCGGACCCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGTTAAAGGAGCTTCCCGAGCTGCTGTCGGTTAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GTTCAGAAACTAATCGACCTCGTTACGCAGATGG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGTCAGGATTCGCGAGATGCGCGCCTTGGCTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CACCAATGCAAAGCGGGATAAGCTCATAGCTATT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TGCCGGCACGAAGTTATCGCGGGCTAAGGACAG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TAGCGATGGACGCAAAGTACGACCGGATGGGCAAG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTCCCTTGCTCACACATAAATTGTACCACGGCAC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GATGACGTACTCGGACCGGAGCCGTGCGTCGCGC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TATGGTTATGGCACCTGATGTTTTTACCAAGGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTCAAGAGACTTACGAGAGAGGTAGGACAGTAGAT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AGGGCTGGACCGTGCTGCTCCTCGTGCAGTCCCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCGTAGATGATATGTGCCTCGTCTATCGCGAGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CACCCCATCACCATACCGCTACCCCAGCCGAGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCCGTGACCTCGGTCTTGTTGGCATGGACCAGTTG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GTCTTCAAGCAGTTGCGGAGTAAGCCTATCATTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AGCAGCTCTGGTACATCACGCTCACCCTCTCTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CAGCAAGATATGCGTATGTGGCTTCTTAGGATCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GATGCCCAAGCGCAAGACCACTGATGATAGGGCCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGTTGAGCATGAGCTGGGCTTCGTCGATGACAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCAAGCATCACGTCACCCCACAGTCAGACCAGCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGCCGGTCAAGAGCAACAAGGGCAAGGCCAAGCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCCATGGAATTAAGTACACCCATCAACGTAGTAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGTTGGCTCTATTTTAACAACTCTAATGGATACCCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGCGCACAGCGCCAATCACTAGCGGGATTAACT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AGGGATACGCGACTGGTCCACCATGACACAGGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CATCTCAGCGCCCAGCACGAGCCGTAAACCTTT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGCCATAGATGATGTGTGCCTCATCTATCGCGA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TGACTAATCGGATCCGGAGGCCAGACTGATGCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	ATGGCCGGCGAGACTCAGAGCGCGCGCGTTCCC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AAGCTGCTGACGGCTGGATTCGGTGCGACGGGCCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGGTGACTCTTTTGTCCTTGTCGTTCTCAAGGCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CGAAGCACCGGCGATTGCTTAACTTGACCCTCTGC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AAGCTGCTGACGGCTGGATTCGGTGCGACGGGCCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCCATCTACCTGCGCTTTTACCCTCACTGTCCTTCAC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC

>NZ_CP012069|22|4|1961937-1963790|PILER-CR
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GATGACGTACTCGGACCGGAGCCGTGCGTCGCGC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TATGGTTATGGCACCTGATGTTTTTACCAAGGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CTCAAGAGACTTACGAGAGAGGTAGGACAGTAGAT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AGGGCTGGACCGTGCTGCTCCTCGTGCAGTCCCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCGTAGATGATATGTGCCTCGTCTATCGCGAGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CACCCCATCACCATACCGCTACCCCAGCCGAGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCCGTGACCTCGGTCTTGTTGGCATGGACCAGTTG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GTCTTCAAGCAGTTGCGGAGTAAGCCTATCATTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AGCAGCTCTGGTACATCACGCTCACCCTCTCTCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CAGCAAGATATGCGTATGTGGCTTCTTAGGATCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GATGCCCAAGCGCAAGACCACTGATGATAGGGCCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGTTGAGCATGAGCTGGGCTTCGTCGATGACAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCAAGCATCACGTCACCCCACAGTCAGACCAGCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGCCGGTCAAGAGCAACAAGGGCAAGGCCAAGCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCCATGGAATTAAGTACACCCATCAACGTAGTAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGTTGGCTCTATTTTAACAACTCTAATGGATACCCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGCGCACAGCGCCAATCACTAGCGGGATTAACT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AGGGATACGCGACTGGTCCACCATGACACAGGCA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CATCTCAGCGCCCAGCACGAGCCGTAAACCTTT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GCGCCATAGATGATGTGTGCCTCATCTATCGCGA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	TGACTAATCGGATCCGGAGGCCAGACTGATGCAA
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	ATGGCCGGCGAGACTCAGAGCGCGCGCGTTCCC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AAGCTGCTGACGGCTGGATTCGGTGCGACGGGCCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	GGGTGACTCTTTTGTCCTTGTCGTTCTCAAGGCT
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CGAAGCACCGGCGATTGCTTAACTTGACCCTCTGC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	AAGCTGCTGACGGCTGGATTCGGTGCGACGGGCCG
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC	CCCATCTACCTGCGCTTTTACCCTCACTGTCCTTCAC
GTTTCAATCCACGCGCCCCGCACGGGGCGCGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_062393126.1|1965910_1966828_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl|CDD|377458
NZ_CP012069.2|WP_050340701.1|1957664_1958858_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271188
NZ_CP012069.2|WP_050340698.1|1954127_1954355_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340710.1|1972057_1973611_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340700.1|1955952_1957449_+|IS21-family-transposase	unknown	unknown	gnl|CDD|226950
NZ_CP012069.2|WP_157051465.1|1954622_1954799_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083443905.1|1958848_1959799_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271178
NZ_CP012069.2|WP_050340708.1|1968675_1969359_-|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl|CDD|187534
NZ_CP012069.2|WP_050340707.1|1966837_1968679_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl|CDD|378245
NZ_CP012069.2|WP_172674468.1|1969413_1971795_-|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl|CDD|350688
NZ_CP012069.2|WP_050340698.1|1951817_1952045_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340699.1|1952298_1954059_+|IS1634-family-transposase	unknown	unknown	gnl|CDD|227708
NZ_CP012069.2|WP_157051464.1|1950434_1951049_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050340712.1|1977064_1977634_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NZ_CP012069.2|WP_050340706.1|1965268_1965901_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|273040
NZ_CP012069.2|WP_050340703.1|1959795_1960782_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271183
NZ_CP012069.2|WP_050340705.1|1964252_1965272_-|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl|CDD|188360
NZ_CP012069.2|WP_050340697.1|1951009_1951717_+|hypothetical-protein	unknown	unknown	gnl|CDD|259835
NZ_CP012069.2|WP_050340711.1|1973816_1976867_+|DEAD/DEAH-box-helicase-family-protein	PrimPol	COG4951_PrimPol_CAS-I:CAS-III	gnl|CDD|227287
NZ_CP012069.2|WP_050340704.1|1963959_1964250_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP012069.2|WP_062393126.1|1965910_1966828_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	3.8e-114	375.3	0.0
NZ_CP012069.2|WP_050340706.1|1965268_1965901_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	1.9e-33	110.6	0.0
NZ_CP012069.2|WP_050340707.1|1966837_1968679_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	3.2e-137	453.1	0.0
NZ_CP012069.2|WP_050340705.1|1964252_1965272_-|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	6.3e-128	421.3	0.0
NZ_CP012069.2|WP_050340708.1|1968675_1969359_-|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	1.7e-81	267.6	0.0
NZ_CP012069.2|WP_172674468.1|1969413_1971795_-|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	1.8e-55	183.2	0.0
NZ_CP012069.2|WP_050340711.1|1973816_1976867_+|DEAD/DEAH-box-helicase-family-protein	PrimPol	COG4951_PrimPol_CAS-I:CAS-III	7.8e-85	279.7	0.0
NZ_CP012069.2|WP_050340704.1|1963959_1964250_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.2e-30	100.3	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_062393126.1|1965910_1966828_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	8.04767e-143
NZ_CP012069.2|WP_050340701.1|1957664_1958858_+|tyrosine-type-recombinase/integrase	gnl|CDD|271188	cd01188, INT_RitA_C_like, C-terminal catalytic domain of recombinase RitA, a component of the recombinase trio. Recombinases RitA (also known as pAE1), RitB, and RitC are encoded by three adjacent and overlapping genes. Collectively they are known as the Recombinase in Trio (RIT). This RitA family includes various bacterial integrases and integrases from the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus H1. All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.61829e-57
NZ_CP012069.2|WP_050340700.1|1955952_1957449_+|IS21-family-transposase	gnl|CDD|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	8.19948e-16
NZ_CP012069.2|WP_083443905.1|1958848_1959799_+|tyrosine-type-recombinase/integrase	gnl|CDD|271178	cd00797, INT_RitB_C_like, C-terminal catalytic domain of recombinase RitB, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	7.41984e-26
NZ_CP012069.2|WP_050340708.1|1968675_1969359_-|type-I-C-CRISPR-associated-protein-Cas5	gnl|CDD|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	1.533e-103
NZ_CP012069.2|WP_172674468.1|1969413_1971795_-|CRISPR-associated-helicase-Cas3'	gnl|CDD|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	2.88603e-57
NZ_CP012069.2|WP_050340703.1|1959795_1960782_+|tyrosine-type-recombinase/integrase	gnl|CDD|271183	cd01182, INT_RitC_C_like, C-terminal catalytic domain of recombinase RitC, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	4.31196e-55
NZ_CP012069.2|WP_050340699.1|1952298_1954059_+|IS1634-family-transposase	gnl|CDD|227708	COG5421, COG5421, Transposase [DNA replication, recombination, and repair].	9.66038e-09
NZ_CP012069.2|WP_050340706.1|1965268_1965901_-|CRISPR-associated-protein-Cas4	gnl|CDD|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	3.98103e-30
NZ_CP012069.2|WP_050340712.1|1977064_1977634_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.52019e-12
NZ_CP012069.2|WP_050340707.1|1966837_1968679_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl|CDD|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NZ_CP012069.2|WP_050340705.1|1964252_1965272_-|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl|CDD|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	3.73193e-156
NZ_CP012069.2|WP_050340697.1|1951009_1951717_+|hypothetical-protein	gnl|CDD|259835	cd13442, CDI_toxin_Bp1026b_like, Mg-dependent tRNAse of the contact-dependent growth inhibition (CDI) system of Burkholderia pseudomallei 1026b, and related proteins. CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the C-terminal toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered. A wide variety of C-terminal toxin domains appear to exist; this particular example from Burkholderia pseudomallei 1026b and other bacteria appears to function as a Mg2+-dependent RNAse cleaving tRNA, most likely in the aminoacyl acceptor stem.	5.89019e-08
NZ_CP012069.2|WP_050340711.1|1973816_1976867_+|DEAD/DEAH-box-helicase-family-protein	gnl|CDD|227287	COG4951, COG4951, Uncharacterized protein conserved in bacteria [Function unknown].	1.57103e-79
NZ_CP012069.2|WP_050340704.1|1963959_1964250_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.15166e-32

Protein sequences

>NZ_CP012069.2|WP_050340703.1|1959795_1960782_+|tyrosine-type-recombinase/integrase
MRGFAQLLSGFLLEYVPRRRSLSENTAKSYRDSFAILLRWLADGRGIAPDDVRIEDLSRENVESFCLWLSDVRGVCAATVNVRLCALRSFASYVSFTEPAYLEWASALRAVEFSKSPSGEVEWLPVEAVNLIMESASSDAREHAMLGLLYDSGARVSEIANARRCDLRLDAPATIRLSGKGRKVRIVPLCDQVAGMASAYLAATAGAPDSPLFVNRSGKAIGRAGITYVLKKHVAAAHEADPLVVPPTTHPHALRHSKAVHLVEADVNIIYIRDFMGHSSVKTTEIYAKISSKSRQKAVEKAAANLIMGSAYGEEDKSAIMEWLRNLL
>NZ_CP012069.2|WP_083443905.1|1958848_1959799_+|tyrosine-type-recombinase/integrase
MPMRIEFTGEYAALMGGYVAFRQNLGFVMPESSQRWLRHMADLLYTMPLISEVIDMERAEAIASRREGESDVTRQSRFVVLRQFCLYLNRIGVGAYVPPAGQVRARSEFVPRIVSEREMARIIEVAEGKALRWPPMVLKILWCTGIRIGEAAALTVGDFHRKDRSLYVAHAKSDRSRIVPVSESLAVDLGEYVDARVPGGDSCRWLFPGRDPGSHRSKVAIGNRLRGIYREARVLTDEGRPIRTHDIRHSFAIATLEKMVEQGRDVYVTLPLLSAFMGHANICDTEYYLRFLPSAHRALVEQEAPISHAVFGDGAL
>NZ_CP012069.2|WP_050340701.1|1957664_1958858_+|tyrosine-type-recombinase/integrase
MMRDLDALASQARGYLVDKGYARSTIAHYEAAWKRLMSWCEDEGIGGYDHDVERRFIEEVVMANADATRYFRLDKSRVLLLLSIDETGEPPDREARRRFVVPAGFDAAYMAYAAELEERGLRASTREGYLCTARNFCEGCGATRPEQLDARSIGVFAEAVSHCAPQTRSAKLYVARDFTRFLARVGACGPEVAAAVPHIPGHKHSTVPSAYSTAEVSTMLESFPRSLRPRRDRAMMLLASVLGMRAGDIKALRLSDIDWRAKTVSFVQRKTQVTNTLHMPEEVWLAVADYIRCERPDVDGDRVFVTACAPYHAIDSSHTFHRTVTRAFADAGVETAGKHHGMHSLRHSAASNMLSGGTPYPTISSVLGHSSANVTKRYLSIDVESLRPLALEVPSCL
>NZ_CP012069.2|WP_050340700.1|1955952_1957449_+|IS21-family-transposase
MIRHGEILRLTALGISQRSIAGSVGCSKTTVQEVQRKAATRRLEWPLSDEMGDEAIRARPCPPQDRSDASKAEIDHEWARREMGRRGVTMTLLWSEYAERAVAAGRTPYMYSSFCHRHQRWVDANPECAMHVEWVPGEWTQVDWAGDTMRVSDPDASSPSRVHVFVACLPFSAHVYAEGFYRMDERAWVEGHVRAFADFGGSTPLIAPDNLKTGVVRNTIDKLIVNEQYRRMLEYHGSAAVPTRVRRPRDKGGVEGAVLIVEREAIAALRDRTFFSLAEPDQALRERVDAINARPFQRREGSRDEMLLGQERACLQPLPQAPYELVERKSATVQFNYHVAFDGRYYSVPFTHIRRSVEVVATRSTVTVSSDGERLCQHQRSHGPKGTYVTDPAHMPRAHRDFAEWSGERFRRWAAEKGPSTLAVTDVILRSRQVEQQSYRTCRALLSLGAYCSFFGVTFRSPSVYRSISHRCVLACGTGADGAHDRVHTGDFAVLGLT
>NZ_CP012069.2|WP_157051465.1|1954622_1954799_+|hypothetical-protein
MQPQCDRVLISNVESGLSFDEMYSWLEDQGDEFPKVREMIIVSRDGRIRHYVRGKPAE
>NZ_CP012069.2|WP_050340698.1|1954127_1954355_+|hypothetical-protein
MPYFKDAATPADVADGGGTVTGYAATFDREPDCYGDVIAPSAGSSPYVGNSSQADVFNDYYARRIASEMGSRDRR
>NZ_CP012069.2|WP_050340699.1|1952298_1954059_+|IS1634-family-transposase
MSYFLKQTRNKKGTYLQIYESTYDPGRGYGTHRSVRAVGYVHELEQSGIPDPVARLRAEVAAMNEEARASRAREGARLVGDSTPERHMGHFPVKALYRRLGIPADIGYLQMASGFRFSLDGLLESLVCARVVAPCSKSRTFHDVLPLLGEEPSFSLGQLYDGISYLGHEYRKVVEAANARVGELFGRDTSRSYFDCTNFYFEIDREDGLRRKGPSKERRADPIVGMGLLLDARCVPMGLEIYPGNESERPRIREVIGALKERHHMTGRTVRVADKGLNCADNVADAVLAGDGYLFSKSVRRLPARELAWVLSEEGWEDHLGRDGRIHHRTKSVTGDFEYRVSREGGGKGTVELRERRVVTFSPRLRSKQLREINRQVEKARRLRLAEARRSEYGDSAKYVTFVAVDSEGEVRDDERVVATLNRKAIGRARSLAGYNMLVTSEADMPEAEVYDTYHRLWRIEETFRVMKSELDARPVYLRRHDSIVGHFLICYVAVLLVRLLQVHVLGDEFGSGQLFGFMRGFRAVRVSERRYVNISRSSPVIDRLKEVTGLPLDHYHLTKGEYDRILGYRFPSLKATGQEESKGSI
>NZ_CP012069.2|WP_050340698.1|1951817_1952045_+|hypothetical-protein
MPYFKDAATPADVADGGGTVTGYAATFDREPDCYGDVIAPSAGSSPYVGNSSQADVFNDYYARRIASEMGSRDRR
>NZ_CP012069.2|WP_050340697.1|1951009_1951717_+|hypothetical-protein
MAGPNARATHAAMNGQRVPIGGRFSNQARWPGDTNLSAAESCDCNCRIEIVSGEGRSKDSRGSKVRKREAGIQRETDKRYREYKSGMNELSERDREARYRRAMGEYVGSFTVEGKVSAKYQAEPWAKELQTTQTLSELGHSVEFLPSTGDGRHPDAMLDGVITDFKRVEAFDPDRVFKLIRKAGSQGAEIVVIDLCLDTVSLDAALEKAAKAVRLGFVEEGHVIVLDWNSEEHVI
>NZ_CP012069.2|WP_157051464.1|1950434_1951049_+|hypothetical-protein
MAKALAGAPGRRHGAGSPRLRARPGEGDVERVEEALEAFYRRQGASLADEALRMGAEDIVLSADADWLDGPRWTDELCDDLFDAMSGLAPAWAADAMTSLGADAGHLDEDAVLAEVRRLSRFRAADIVRSASERVVSDLGDLDELTPRGAIEATTRRLMASGATAGPSRLPPPTARRSRARGSPASSARRSGWRGPTPGRRTRP
>NZ_CP012069.2|WP_050340704.1|1963959_1964250_-|CRISPR-associated-endonuclease-Cas2
MYVLVTYDVASGDVGGPRRLRRVAKICTQYGQRVQYSVFECLVDPGQYESMKHELARIIDEGRDSLRFYNLGKNWKNRVEHIGAKDSYDPEDLLCI
>NZ_CP012069.2|WP_050340705.1|1964252_1965272_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MKRLLNTLYLTNPDAYLRKKDDALAVYVEQKKVMSVPFHLLEGVVLFGHVGCSTAVLGACATRGISVAILDEGGRFQASVRGPISGNVLLRREQYRRSMDVIECLSAARRFVAAKVHNSRVVLQHYVRDYPDMEGIGAGDAIRELKQSGEEIRRCNNLDELRGIEGNAAHVYYSAIQGALRCDGVTFTGRTRRPPKDPVNSALSFFYTMLSRELMSACESVGLDPQMGYLHACRPGRASLALDFIEEFRAPMVDRFVLSLFNRKQLVASDFLAESQGFLLKDSTRKKVLGYWQQKKQDQLTHPFLGERMPLGLVPFIQAQLFARYLRGDLNDYPAFLWR
>NZ_CP012069.2|WP_050340706.1|1965268_1965901_-|CRISPR-associated-protein-Cas4
MYDEDELLALSGLQHLAYCERQWALIHLEQIWQDSADTLRGDYFHERVDTVGYSCTDGVRSERRVRLVSRSLGIYGVADIVEYGVGDVGSFVRPIEYKVGKPKLEDWDRIQITAQALCLEEMHGLKIPEGALFYGETRRRERVEVTQKLRRKVDSLSLRMHDLFEMGVTPPAERNSKCRRCSLANECMPEAGCVDARSYWVRYGEDLELT
>NZ_CP012069.2|WP_062393126.1|1965910_1966828_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MPEPIQNRYDFVFFCDVKNGNPNGDPDAGNLPRIDPDTSQGIISDVCIKRKIRNYVDLIKGEAIDDPDVNEGELGYKIYVQESAVLNERNRKAYVHYKLIPQAKKLPKKVEDQIKVTKFMCDNFYDIRTFGAVMTTGVNCGQVRGPVQLCFGESIDPVVPLEMSITRMAATEAKEDKDNKTMGRKQYVPYGLYRIEGFVSASLAEKNGFCQADLDLLWEALMNMFENDRSAARGLMTSRELIVFKHESKFGNAPAHRLFDLVHVDKVDSKNQVAREFGDYTITIDEGKLPQGVEIRTYDYIAPSA
>NZ_CP012069.2|WP_050340707.1|1966837_1968679_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MIVKDLYDLYERYAADPQMQDKVPPKGMSREKVEWELVLSESGALVNVIPLSHGDGKGSNRYCVMTVPEHRTRTSGVSPFFLCDTAAYLLGMADISKAKDESEVVKAQRKAQERWEASRDYHLSILSSCDDVAAQAVMGFFSHNILKERENDDLLRDIAESGNLIFALKDSDGNIVPIHESKAIMAAWESSHVSALADEPCIRGQCSVTGKVAPLARLFPQVTGLAGAQSSGASLISFNCDSFNSYGRTQAYNASVSQWVAFGAGTALKMLLSDPERKIRLGATTFTFWSDRPSPDEDSLFIRFFGGGDKNDTAEDSATVTRVRDAIKGIKSGHPLRANFNPDVRYYVLGISPNAARLSVRFFETSTLGEVAERYGQYLRDIDMVDVSTTSIFQLIRQCAVQGKYENLPSTLVNPCMRAMLTGSRFPQSLLSTLLSRMRADHGSNNRWDMGQRASLIKACLVRNLQSTRESEIDVALNRDNNCVGYLLGRLFAVMERAQSEALGTTNATIRDKYIGSASVTPARVMPTLMHGCQNHLSDLRKKKPGLNVILEKELDEIVGRKLSDNPYPGTLSMEDQGEFFIGYYQERVDLWTSRKRDDVAPDEAASNDLSEN
>NZ_CP012069.2|WP_050340708.1|1968675_1969359_-|type-I-C-CRISPR-associated-protein-Cas5
MGYGIRILVKGPRACFTRPEMKAERVSYDVITPSAARGILEAVYWKPAISWCIDSIEVLNEIRFETFRRNEVESKLPYSGKSGAKSIADGKNLPLYEVASEDRQQRATLLLRDVAYIINAHFDLTDRVGEGDTVEKHYNIALRRLRKGQCFNQPYFGCREFAAEVSLLEEGEEASPSFYAGISEKDLGFMLYDLDFTDVRKPEPRFFRAVMKNGVIDVSAALQEVVG
>NZ_CP012069.2|WP_172674468.1|1969413_1971795_-|CRISPR-associated-helicase-Cas3'
MAELSAQFAATFGYGQWGRALGLLHDAGKVCDRFQNERLFNRPVSVDHAAFGARRALELYGGCGDKNDAAGTRAYAGELMAYAILGHHGGMKSAIPDAELRIERLDSPPDHGQVADDYGPYQDMLSESPDSIPPGRPSLEPTSLARLMQSPLGVRRDVMQQLLPFSAQALTRMLFSCLVDADWLDTERFMSPEEAKKRGHDYDSTSTLLERLESHLEKLSHGNRETPVNMARNAVLTDCKEGSASKPGLFTLTVPTGGGKTLSSMEFALRHATVNGLERVIYAIPFTSIVEQSAAVFRDILGEENVLEHHSNYDFDAAAGEGREYERLAVQNWDAPIVVTTNVQLLESLFANKPSKCRKLHNIANSVIVLDEAQTIPIELMRPTLAALEELTIDFGVSVVLCTATQPAVQDEWPFGSHPHELCGPHQELFSIAFDGRVRYQVVGELPEAELADKLANEHQVLCVVGKKAEALNLYRDVVTCARESGLFNETKKSYDAGFFHLSAHMIPLHRSQMIAKIRKRLDAGKRCVVISTQLIEAGVDVDFPIVWREMAGLDSIVQAAGRCNRNGRRVDEVGEKIPGDVFVFELTEQDDAFSRPGPRTFLGKTRLIASELLNVDGLSIDATSIDLYFRRLYQTESLDAQCVIEIDDKGRKRRGSRGLYEEISDCQRHLSSSKGFLSCYMDYGYDFEVYARTYKVIDDEGEPVFVPWDEGGRRQLKHLLDSIGQEASLIRSLQPYSVSVYKNLMQDLEREGLIEHYGLVSVLRMEDDCRKVYSEETGLLPPDEEVLNILAM
>NZ_CP012069.2|WP_050340710.1|1972057_1973611_-|hypothetical-protein
MPEATTPGTTTPKITTPIYHYIREAVTDGELPDDFSLRPYDRGDQELFMADGAMDGMCIYHMARPELPADLDAQIGSALMLASSGEPVAADEAFSSLANKFRSIRIIDQVVDGVRTRRDQLDPAMIYHYAKRLVLTSTDKELLKIGLELFELLREPDDQLKDAMRTLGLSDEFTTFVVFDMMMQWTNGNDEIFRLVQKVHGWGRIHAIERLEPSTDEIRDWFLFEGVNNNIMPAYSALTCFNKSGLAERIARGLSPKEFRGAGAVMEALVDEGPVEGISVLDDPAGILGAYVDQARTQDVGTDDLSVISAIRRYAKDKKMGKVASACDDLLNSPDSRQKVADAVSRGDVTAFMLAEQLGIPYHEELLRAMGTNFRWLFTRIGCLIDDERYIDQALELARTGMPLDAIEQEPRDESGLGPGHFAYLALGFVLQPLCGHVLKGTDIVERALMSPVVRNRIEAHRVLRSWVSSKRIPLAELSPELYARLGEAYNAEPKEDLRQSMRPLLDGAITFPKEDM
>NZ_CP012069.2|WP_050340711.1|1973816_1976867_+|DEAD/DEAH-box-helicase-family-protein
MGESAVPCARHAIIGGSEASFVELVSHADGRSSIVIYTVDGGRRLYATEVEWQQGATLLAQQIEAQAAERQTTGAQGLVTSKSSAKDKLSLFRSLFVGRGDLYAHGYRKRSGGIGYTPACANEWVAGICPKRANPHARCADCPQRSFIPLSNQALVKHFNGNRCDLKDVVGLYVVQADCTVSLLVADFDGTGWQRESLAYVHAGRSLGVDVALERSRSGDRAHAWVFFDEPLPSPLARDFGSLLITRAMDNGLIRYFDAYDRFYPAQDTIAKGGFGSLIALPFQGQAQRLSNSVFVDDQLKAHPDQWRYLSSVRKTSRDLVERTLAATCGQALGELAFLRPRTKEAGQGRPLPTQTPSESLCPDGRTEVLKGISPFLTVAITKSNMLFINRCGLPATVQGRIRRLAALSNPEFYRAQAMRQSVYGKPRIIDQGLMDETTIAIPRGCEKGLLCLLDGLGISYHVEDRRFVGTPIRASFTGNLRPSQQTAADELLRHECGILSAPTGFGKTVIAAYLIGALRLQTLVIVPSTPLLDQWQERLATFLSIDEELPELLTKTGRTSRRRRSLVGRIGGGRSVPGGIVDIATYQSLLEGRELSGGRRIKGLVRSYGMVICDECQHGAAPQLAQVLATTTASRVYGLSATPRRSDGLEGILYMQCGAVVHRVDPRQQAQEQGFARLLEPRFTHIRLAGIEAGSSFNQVLDRLCAHPARNRLIAQDTVLALRAGRRPLVITRRREHAALLAKLVLEQGFKVFLLSGAMPARERREQVREIAEAADDVSFAVVATGSYLGEGFDEPRLDTLVLATPVSWEGVVTQYLGRLHREREGKSEVIVYDYVDTSVPMLDRMYKKRLKSYARLGYELIPASDDVDRTAGSIVGPSDCESLLFADLDSSKRSVHLAVPYLSHRYVLTLRPRLSAVVERGVHVSIVINQPKDPRGIARAQQGVELLRSMGCLAELREWRRSALAIFDESIVWHGSLPLLAQPHKDDCSLRLTSSEVAYDLLRDEGLATRQGGA
>NZ_CP012069.2|WP_050340712.1|1977064_1977634_+|helix-turn-helix-transcriptional-regulator
MEAERFGSFVAQRRRERGMTQATLASELHVTDKAISRWERGVGFPDIGNIEPLADALGVSIVELMRAEKTEEQTMTTDEAEDACTKVLDITKSQQERETKDVVALIASLAVLTLLAEMIASLRWDGAKLSITMNIPVTYPLIPVALIVYAIWRKVKGQTCELAASVGITLLVIPAIILLSSFLLSAMTT

Crispr_ID: NZ_CP012069_23

• CRISPR_ID: NZ_CP012069_23
• CRISPR_location: 2080244-2080329
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_23

Consensus_repeat	Method
GTGCCCCGCAGATTGGCGGGCACT	CRISPRCasFinder

spacers of NZ_CP012069_23

>23.1|2080268|38|NZ_CP012069|CRISPRCasFinder
AAGATCTTGGACCCAACTGGGCAAACGTCTCAAAGACG

CRISPR arrays and Neighbor proteins around NZ_CP012069_23

CRISPR arrays

The CRISPR arrays of NZ_CP012069_23

>merge|NZ_CP012069|23|2080244-2080329|CRISPRCasFinder
GTGCCCCGCAGATTGGCGGGCACTAAGATCTTGGACCCAACTGGGCAAACGTCTCAAAGACGGTACCCCGCAGATTGGCGGGCACT

>NZ_CP012069|23|20|2080244-2080329|CRISPRCasFinder
GTGCCCCGCAGATTGGCGGGCACT	AAGATCTTGGACCCAACTGGGCAAACGTCTCAAAGACG
GTACCCCGCAGATTGGCGGGCACT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050340794.1|2081415_2083170_+|OPT/YSL-family-transporter	unknown	unknown	gnl|CDD|224216
NZ_CP012069.2|WP_050340796.1|2085014_2087774_-|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl|CDD|366019
NZ_CP012069.2|WP_050340782.1|2065619_2066813_+|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NZ_CP012069.2|WP_050340788.1|2073297_2074722_+|class-II-fumarate-hydratase	unknown	unknown	gnl|CDD|234779
NZ_CP012069.2|WP_050340787.1|2070444_2073252_+|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|341060
NZ_CP012069.2|WP_050340790.1|2076219_2077011_-|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl|CDD|319819
NZ_CP012069.2|WP_050340799.1|2098618_2098996_-|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl|CDD|234671
NZ_CP012069.2|WP_050340793.1|2080402_2081224_-|type-III-pantothenate-kinase	unknown	unknown	gnl|CDD|237347
NZ_CP012069.2|WP_050340789.1|2075152_2076046_+|hypothetical-protein	unknown	unknown	gnl|CDD|119376
NZ_CP012069.2|WP_050340783.1|2066781_2067504_-|tRNA-synthetase-subunit-beta	unknown	unknown	gnl|CDD|225917
NZ_CP012069.2|WP_157051592.1|2094846_2098305_-|DNA-directed-RNA-polymerase-subunit-beta	unknown	unknown	gnl|CDD|234749
NZ_CP012069.2|WP_050344514.1|2067860_2068817_+|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl|CDD|240638
NZ_CP012069.2|WP_050340800.1|2099092_2099611_-|50S-ribosomal-protein-L10	unknown	unknown	gnl|CDD|234632
NZ_CP012069.2|WP_050340795.1|2083390_2083852_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083443917.1|2069158_2070448_+|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl|CDD|379084
NZ_CP012069.2|WP_050344516.1|2089521_2090073_+|glutathione-peroxidase	unknown	unknown	gnl|CDD|238207
NZ_CP012069.2|WP_050340791.1|2077350_2079573_+|anaerobic-ribonucleoside-triphosphate-reductase	unknown	unknown	gnl|CDD|236436
NZ_CP012069.2|WP_172674472.1|2068839_2069100_-|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl|CDD|366058
NZ_CP012069.2|WP_157051591.1|2088070_2089378_+|lipopolysaccharide-biosynthesis-protein	unknown	unknown	gnl|CDD|225153
NZ_CP012069.2|WP_050340797.1|2090329_2094841_-|DNA-directed-RNA-polymerase-subunit-beta'	unknown	unknown	gnl|CDD|184899

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050340794.1|2081415_2083170_+|OPT/YSL-family-transporter	gnl|CDD|224216	COG1297, COG1297, Predicted membrane protein [Function unknown].	4.54163e-38
NZ_CP012069.2|WP_050340796.1|2085014_2087774_-|phosphoenolpyruvate-carboxylase	gnl|CDD|366019	pfam00311, PEPcase, Phosphoenolpyruvate carboxylase.	0
NZ_CP012069.2|WP_050340782.1|2065619_2066813_+|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.28857e-10
NZ_CP012069.2|WP_050340788.1|2073297_2074722_+|class-II-fumarate-hydratase	gnl|CDD|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_CP012069.2|WP_050340787.1|2070444_2073252_+|VWA-domain-containing-protein	gnl|CDD|341060	cd09597, M4_TLP, Peptidase M4 family including thermolysin, protealysin, aureolysin, and neutral protease. This peptidase M4 family includes several endopeptidases such as thermolysin (EC 3.4.24.27), aureolysin (the extracellular metalloproteinase from Staphylococcus aureus), neutral protease from Bacillus cereus, protealysin, and bacillolysin (EC 3.4.24.28). Typically, the M4 peptidases consist of a presequence (signal sequence), a propeptide sequence, and a peptidase unit. The presequence is cleaved off during export while the propeptide has inhibitory and chaperone functions and facilitates folding. The propeptide remains attached until the peptidase is secreted and can be safely activated. All peptidases in this family bind a single catalytic zinc ion which is tetrahedrally co-ordinated by three amino acid ligands and a water molecule that forms the nucleophile on activation during catalysis. The active site is found between two sub-domains; the N-terminal domain contains the HEXXH zinc-binding motif while the helical C-terminal domain, which is unique for the family, carries the third zinc ligand. These peptidases are secreted eubacterial endopeptidases from Gram-positive or Gram-negative sources that degrade extracellular proteins and peptides for bacterial nutrition. They are selectively inhibited by Steptomyces metalloproteinase inhibitor (SMPI) as well as by phosphoramidon from Streptomyces tanashiensis. A large number of these enzymes are implicated as key factors in the pathogenesis of various diseases, including gastritis, peptic ulcer, gastric carcinoma, cholera and several types of bacterial infections, and are therefore important drug targets. Some enzymes of the family can function at extremes of temperatures, while some function in organic solvents, thus rendering them novel targets for biotechnological applications. Thermolysin is widely used as a nonspecific protease to obtain fragments for peptide sequencing. It has also been used in production of the artificial sweetener aspartame.	3.77638e-29
NZ_CP012069.2|WP_050340790.1|2076219_2077011_-|Cof-type-HAD-IIB-family-hydrolase	gnl|CDD|319819	cd07517, HAD_HPP, phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily. Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.88947e-58
NZ_CP012069.2|WP_050340799.1|2098618_2098996_-|50S-ribosomal-protein-L7/L12	gnl|CDD|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	1.84593e-42
NZ_CP012069.2|WP_050340793.1|2080402_2081224_-|type-III-pantothenate-kinase	gnl|CDD|237347	PRK13318, PRK13318, type III pantothenate kinase.	3.94267e-76
NZ_CP012069.2|WP_050340789.1|2075152_2076046_+|hypothetical-protein	gnl|CDD|119376	cd06414, GH25_LytC-like, The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a C-terminal glycosyl hydrolase family 25 (GH25) domain and an N-terminal choline-binding module (CBM) consisting of eleven homologous repeats that specifically recognizes the choline residues of pneumococcal lipoteichoic and teichoic acids. This domain arrangement is the reverse of the major pneumococcal autolysin, LytA, and the CPL-1-like lytic enzymes of the pneumococcal bacteriophages, in which the CBM (consisting of six repeats) is at the C-terminus. This model represents the C-terminal catalytic domain of the LytC-like enzymes.	9.21205e-75
NZ_CP012069.2|WP_050340783.1|2066781_2067504_-|tRNA-synthetase-subunit-beta	gnl|CDD|225917	COG3382, COG3382, Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only].	1.00361e-67
NZ_CP012069.2|WP_157051592.1|2094846_2098305_-|DNA-directed-RNA-polymerase-subunit-beta	gnl|CDD|234749	PRK00405, rpoB, DNA-directed RNA polymerase subunit beta; Reviewed.	0
NZ_CP012069.2|WP_050344514.1|2067860_2068817_+|2-hydroxyacid-dehydrogenase	gnl|CDD|240638	cd12161, GDH_like_1, Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family. This group contains a variety of proteins variously identified as glycerate dehydrogenase (GDH, aka Hydroxypyruvate Reductase) and other enzymes of the 2-hydroxyacid dehydrogenase family. GDH catalyzes the reversible reaction of (R)-glycerate + NAD+ to hydroxypyruvate + NADH + H+. 2-hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	0
NZ_CP012069.2|WP_050340800.1|2099092_2099611_-|50S-ribosomal-protein-L10	gnl|CDD|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	1.61901e-52
NZ_CP012069.2|WP_083443917.1|2069158_2070448_+|zinc-ribbon-domain-containing-protein	gnl|CDD|379084	pfam13240, zinc_ribbon_2, zinc-ribbon domain. This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.	8.60052e-07
NZ_CP012069.2|WP_050344516.1|2089521_2090073_+|glutathione-peroxidase	gnl|CDD|238207	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per subunit, which is involved in catalysis. Different isoenzymes are known in mammals,which are involved in protection against reactive oxygen species, redox regulation of many metabolic processes, peroxinitrite scavenging, and modulation of inflammatory processes.	3.36468e-81
NZ_CP012069.2|WP_050340791.1|2077350_2079573_+|anaerobic-ribonucleoside-triphosphate-reductase	gnl|CDD|236436	PRK09263, PRK09263, anaerobic ribonucleoside triphosphate reductase; Provisional.	0
NZ_CP012069.2|WP_172674472.1|2068839_2069100_-|cation:dicarboxylase-symporter-family-transporter	gnl|CDD|366058	pfam00375, SDF, Sodium:dicarboxylate symporter family.	4.23934e-08
NZ_CP012069.2|WP_157051591.1|2088070_2089378_+|lipopolysaccharide-biosynthesis-protein	gnl|CDD|225153	COG2244, RfbX, Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only].	7.99081e-09
NZ_CP012069.2|WP_050340797.1|2090329_2094841_-|DNA-directed-RNA-polymerase-subunit-beta'	gnl|CDD|184899	PRK14906, PRK14906, DNA-directed RNA polymerase subunit beta'.	0

Protein sequences

>NZ_CP012069.2|WP_050340791.1|2077350_2079573_+|anaerobic-ribonucleoside-triphosphate-reductase
MKIIKRNGSEVAFDLQKIINAIKAANKEVPPDERLSKREVKFASRNVKDQCAAAGHTVTVEEIQDLVEDQLMALDHFSVARKYIIYRYVQNLKRHKNTTDDKILSLIESNNEEVKQENSNKNPSVVSVQRDYMAGEVSKDLTMRELLPSEVVTAHDEGIIHFHDADYYAQHMHNCDLVNLEDMLQNGTVISGTMIEKPHSFSTACNIATQIIAQVASCQYGGQSISLAHLAPFVDISRKKIRRQVYVELETIGARPEDRVINQIVEKRLRDEVARGVQTIQYQVVTLMTTNGQAPFITVFMYLGEAKGEQERKDLALCIEEMLRQRYQGVKNEAGVWITPAFPKLIYVLEEDNVHEDSRYFYLTKLAAKCTARRMVPDYISEKKMREYKLSKGEVAGSGDVYTCMGCRSFLTPDRSGNGYDNVANAGNWEPGKPKYYGRFNQGVVTINLPDVALSSGRDPNRFWELLDERLELCHTALRCRHERLKGTLSDAAPILWQHGALARLKKGETIDRLLNGGYSTISLGYAGLYECVRYMTGHSHTDKEATPFALAIMQRMNDRCSEWKAAEDIDYSLYGTPLESTTYKFAKCLQRRFGLVEGINDHGYITNSYHVNVRENIDAFTKLKFESEFQRLSPGGAISYVEVPNMQDNLGAVIKVMQYIYENIMYAELNTKCDYCQTCGYSGEIHIVEDDGKLVWECPNCHNRDQSKMNVARRTCGYIGTQYWNQGRTEEIRDRVLHL
>NZ_CP012069.2|WP_050340790.1|2076219_2077011_-|Cof-type-HAD-IIB-family-hydrolase
MAIWNTPSTIKAIFFDVDGTLLSFKTHRVPETALMALSELKKKGVKCFLATGRPPYQLDEISIDNLEAFILFNGQLCLTRDEVFFDECLDKDDVATVVDQVRQGLYNCTFMEKNRCYVSGYDEHVRAIEKIAGTTLPVADVAQALDNDIYQLNAYITPGNTDILTNATKHVKLTRWSEHFVDVFPRHGGKHTAVRRMLKRYGIASESAVAFGDGGNDLSMFGVVGTSVAMGNGNDDVKEQADYVTDDVEHDGIYNACVRLGLL
>NZ_CP012069.2|WP_050340789.1|2075152_2076046_+|hypothetical-protein
MPTERRKHLPLARLLTVLGLIIVTLITLKLTAFRDEGSASEGSGTPSLKGKSMAIADTTTMNLSPYAWGSLSTQNGYLAYIKNGELLSKLGVDVSEHNGEIDWSRVKGAGVQFAYIRVGYRGSHAGNVVADARFAENIVAARQAGLAVGVYFFSQAKTEEEAREEADFAAKRLAGSNVEYPIAFDMEPDAEGADRISKLSGRELTAIATAFCEQCEKNGYHAIVYGNRYDLSQYDLKRLAGYGFWYAEYGSKPTSSLRFGMWQYTKTGNVDGIEREVDIDLDLTDALAREDEGKPAS
>NZ_CP012069.2|WP_050340788.1|2073297_2074722_+|class-II-fumarate-hydratase
MDADDTNRGANADKGAYRIEHDSMGEVRVPQDTPWGAQTQRSLENFRIGTETLPRGMVRALTLVKKAAAQANVELGVLDRQLGTLIEEAADEVLAGLHPGAFPLRVWQTGSGTQSNMNVNEVLAHVANGLATRHGVSLARPVHPNDHVNCSQSSNDVFPTALHVAATLAITEELLPSAHKLASTLRQLEEKNEGIIKCGRTHLQDAVPIAFSQEISGWRSLVETPCEQLEATLEGLGRLALGGTAVGTGLNAPADFDSLAAERLSALTSHSFRPAPNKFHALTSKDAVVFAHGAVKALACNMMKVANDVRWLASGPRLGLGEIRIPANEPGSSIMPGKVNPTQCEAVTMVAVQVMGNDAAIGIAASQGNFELNVFMPVIAYDFLQSVRLLADAVSSFDAHCVRGIVANRERMEANLRNSLMLVTCLSPHIGYERAAKVAQSAFAGGTSLREACVSLGFLSGEAFDAICKPQEMV
>NZ_CP012069.2|WP_050340787.1|2070444_2073252_+|VWA-domain-containing-protein
MSTATDGHRPTPRLAYITLLALGIVFTVLGVVGYITQSPAQGQSLQEARNPKSAQVDEENGTVAPEADAPASDTLEDARNQWYAEAYFPSKVNDHFEAADALAIIRLTIGSKVNIREEADLETEELHHYRFSQTYEGLDVHARGVTLTVAKDGTVIGASSNLVDVQDVPTKEKVERPAAEKTALEHVAQLSGQPKEDLRASGSKLLVYSIETEPTLSWRFMVETPSGDFETFVDAQSGTVIASLSTKTNAQSERVNATGQRGTTYTLDITDNKEASNLDDSERRISVYTLGWKPDIDSERSKSKIATTSCMSGVDALGNLAATYDFYMNYLGWKGYDGRNSQLKAYVEATDTEMGDNAYWDREKNIIVFTSREDQALQHSSGLDIVAHEYTHAVTQYTCKLTGGKTSASAAVDEALSDILGEATEKAVTGTCDWMIAAGSQVSGGTIRHFDNDQHYTKGAECHTNALVIDRIAYHIGNGQDNVRGHTKEQTRLFDASDPHDKRGLKTYARLWHNVQRMLTPTSTLRHLSSVTCEMARHMRDAGELSEAQYDGVVAAFTQEGLAPLIKRPRSAAEGETGSATALVFDVSGSMSGQAEQANQNKGADQSTGRATKLDVAKQAGNELVSRVEKMDGRYQKQFLLGIASFAQKAKNLALPTSDLSIIRTAIEGLEAGGGTNIKDGIEKGIDQVKSYDGHRAILLLSDGEDTAGNSDSEILATAAEAKRNEIVIYTIGLGADDSDLDGELLQDIAEETGGTYLRADPNDVISLIAGFLHAQADTTGDILSEQKGTLSKGQTSDAEHFEITDKAGDLDALLYWPGSQMQTILVDPTGRTVNEGYHGAELDTQTIPSEITIKDPLPGIWSVQVHAEETSQDNEPYYSLVSFQEVDGPATRPLSAIARASAIALPVGCILVVVSLTLLITGSGRRQTSGAAVT
>NZ_CP012069.2|WP_083443917.1|2069158_2070448_+|zinc-ribbon-domain-containing-protein
MYCPACGVALRDGARFCPTCGAPVPTGVAPGGQTWVPRPHAPQQTQVTAAPRAQASPTPAASVSTRAAHAPLILSRLSVRNEAVLEVVCTLAIASLLAILTFAPGFVVTPTWGRLASARTSLSLSGLLILLFSGSGTQNPTMTSVSASILIAITTLGAIAAWIATGLFTAAGRHERPSHALAVALTTLSLIALLGTQSLWQLVCPWLCRGQPLGLEHLRLDLVDSPSFPLTAPLLSTAISVMAVEAITRKKAMAQEGSQHPDREACAQSVLCALGLALCVTLLCGVPVLAQVDRGSSLSLTGLALIIYTCASGWVPGIVGAAIVIALLMLTLTVGTMQVSRIARDEVSRAGMVVTCILTTLFALSVVTYVYLANSPGTAPALLPLPFYPSIAMWVLLVTVMALPMVTTAWHCASMGARAHTRSGDGGAQ
>NZ_CP012069.2|WP_172674472.1|2068839_2069100_-|cation:dicarboxylase-symporter-family-transporter
MAIVIRTMALPAEGIAPAIFAGIDWIMGVFRTVLNVNSDVFCALLVACLEGKINYKSAQCLGLCPTDPRAGARRGRTSARRIHLRL
>NZ_CP012069.2|WP_050344514.1|2067860_2068817_+|2-hydroxyacid-dehydrogenase
MKISLIEPLGVPVETIERLAANIRAAGHEFVHFEDKASDASEQLRRAEGSEVVMIANSPLPADVIKGIGTLKMIAVAFTGIDHVGLDACRERDIMVCNCAGYSDTAVSELAVGLAIDVLRKVRQGDHAARHESTSAGLVGREIAGKTVGIVGCGKIGTATARLFKAFGARVLGYSRHVNPVAVSAGVEFTALDTLLGQSDIVSIHLPLNEQTRKSFGASQIAAMREGSVLINCARGAIVDNDALADALASGHVAGAGIDVFDMEPPLPADYPLVQAPNLILTPHVGFLTEESMERRAKIEFANVEAFLSGTPQNVCVL
>NZ_CP012069.2|WP_050340783.1|2066781_2067504_-|tRNA-synthetase-subunit-beta
MKSFVIEDSFWEVFPKVEIGIVCVDGILPASQIADESAKRAARLLDHANDSAERWISSNTISQNEVVAVWRDAYKRFKTKKGARVSVENLIKRVMKDNPVRHINPAVDISNAISLKYALPIGVENIDAIEGDFRLAMTEGGDYFLPIGETESDPTLPGEIAYLDDAGAVCRCWNWRDGQRTQASDETPHCMFIMENVDPARSADLHAAIDEMAELAEAILGGTVTNKDFLTKDHPKTALA
>NZ_CP012069.2|WP_050340782.1|2065619_2066813_+|CPBP-family-intramembrane-metalloprotease
MVFQRAYVQAMRLVPGYRWWRPLLALILAAVFIILFLILFQLPFVLYFLHIRYSGAPDAIGIQETLDGLVAGGYKGFLASNPTSILLLEGSIVLLIPAIALALRLAGLRGLGTLSSVDGHLRWNRLGSYLVPAFGLVFAIGFALPWVLQQAGSATWELPHPRIVPVALMAILVLVPLQSAAEEYAFRGLLQQVPGSWISAVWVPVLIQSLLFAAGHRYNFAGQLGIACMGLAMGVLTIRLGGLEATIAFHVANNLLSLLSSSLFTDGAVSSTVDTMELLVSVAISLVYAWVALAIAKRRGWLASDPPDLDEQFALASGQLGQVTDGSTAPPDSGEGLSGRGGAKVGWDVSQPPRSPGIAPQSLTTPPDPLGREDPGNVLDSSATTQDPTPGQSWDDL
>NZ_CP012069.2|WP_050340793.1|2080402_2081224_-|type-III-pantothenate-kinase
MDGTEWEAAAPGGVLAVDVGNTTTVVGVFEVASAPSADPSLRWELTTPRNLTSDEAFLLLNQLFGNWRASGAILSCVVPTHVAAWQAALTRAGNARPFVVGPGLRTGLKMHYRDPAEIGPDRIADAVAMRERYQMPAVVIDFGTTMNIEVIDAQGAFVGGLIAPGLALGARALSKRTARLPVVEIEMPKEVIGRSTREAMLSGIVFGEVARIDGLLDRVFAEIASEATVVLTGDYAHEISGLISHEAAVDDTLTLRGLHQLYLLNAAGSKRGS
>NZ_CP012069.2|WP_050340794.1|2081415_2083170_+|OPT/YSL-family-transporter
MDENGRRTRLRDELSVPGFVIGIIGCVILTATSAYTALKMGALPWPTIFTSVTSLLLLRAFGRRDIAEANVTQIVMSAGSMVAGGLAFTIPGVWMLGLPGKVSWWEMLFVALAGTLLGLVCTALIRRRFVDDSTLSYPIGTAAAETLKAAQVGGSTGIRLFGSMGLAGLWCVLRDGLNVLPQFFLQLTTPGVNFAIYNSPMLLSMGYLVGFVPMLFWLGGGVVANLGLIAGATAAGAWSVEVAQKIVKSLGMGLMMGAGIAVVLKDVLPQLMGIRHGRGNTTGGKPTDDEQGSSTSHSAPVGDRARWASDVRGKSDAGFLALLTALAALTACFGLSLGPIPTVIIVILSFVTTIMSAQSTGQTGIDPMEIFGLIVLLLVAAVSNLSQLSLFFVAGIITVACGLAGDVMSDFKTGSILGNNPRTLWKAQALGALIGVFVAVATMVAIEQAYGPDTFGPNRPFIATQASVVATMVSGIPSVPAFMVGLVAGIVIYCLGLPAMMVGLGVYLPLYMTVTASLGAAIKLVLDKRAARRRNGLRGSEGGDRSVDETPAQDDGIVVASGVLGGESIVGVTIAFVTIVRNLG
>NZ_CP012069.2|WP_050340795.1|2083390_2083852_-|hypothetical-protein
MDNVLLFSYFVFMILMPALPLLAGGDYGYSLPLGHGYFMPLSLFYNTALALVFSATIVWRRLRWVPVAGEMVGESYDLVGLRIATHAWRYEFRGLVYETEDVDPVDILNTRRHGTVWVDPDCPSRILPPSWRGRLLIYLLFGAIPVYMLLESL
>NZ_CP012069.2|WP_050340796.1|2085014_2087774_-|phosphoenolpyruvate-carboxylase
MSEIDQLKDEIAAKVANSSLGERELEQIVARSTVSVVDIPDELKENLALFLRLVRTVLAEFDPKLREAFDQLLADSITVNARADGDADEGAFKDASAIIETLDVESAVMLARAFAAFFHLANICEEDYRVRSLRAREAAVPTIADEDPVNDITVAYRRLVEECGQDEASALLGRLEFHPVFTAHPTEARRKAVEGKIRRISALLEERAQASGIALAENERRMLQEIDALLRTSPIAIKKPTPVQEAETVIDIFDHTLFDMIPEVYRRFDDWELGDKAGTVPPVCPAFFHPGSWIGSDRDGNPNVTAKLSRQVAERYRAHVLEKLADATYAVGSSLTLDTSSTKPSDQLLNLWSHQVEMSESLTDHARAISASETHRASMIIMSHRLRATIDRTADLMYANADEYLKDLYCVQRSLAEAGAVRAAYGPVQKLIWQAQTFGFHLVEMEFRQHSLVHSRALKDIREHGRWCERGELQPMTREVLDTFRAIGSIQRRNGTRAACRYIISFTQSAQNVADVYELARLAFAHTQDVPTLDVIPLFEQIRDLENAVDILDEIIKLPPVRERLEQTGRKLEVMLGYSDSSKDEGPTAATLVLHGAQERIARWAEKMDIDLVLMHGRGGAVGRGGGPANRAVLSQPTGSVNCHFKLTEQGEVIFARYGNPTLALRHVESVAGATLLQSAPSIGYVNGESTKKYADMAALLDSASRERYLDLLGTDGFVEWFSSVTPLAEIGLMPIGSRPAKRGLGAQSLDDLRAIPWIFSWSQARVNLAAWYGLGSACERVGDLGLLRDAYAEWPLFTTFIDNVEMSLSKADERLAKMYLSLGGRTDLSEKVLDELRLTLRWVLAITDDERPLGNRRILGPVIRLRLPFVNALSLIQVLALRRLRERGESLTPEERDRLTYLILCTVSGVSAGLQNTG
>NZ_CP012069.2|WP_157051591.1|2088070_2089378_+|lipopolysaccharide-biosynthesis-protein
MVVRLANQWWDRLIGAVFSGSLANQTARYAAHRTTRDYVFNSVGFGVWGFLFPLLTMVASQLVGTEGAGMFSMAFVYANLIQFVGMYGVRTYQVSDVDEMDSFGAYQIQRVLTCILMVGVGYLYCSLRGYAGELLWICFGTFAFRTVDSLADVYEGRLQQQDKLWLGGASQVLRCVLAIITFSVALLATRSVSLACIGMAIAATLSLVLFTIPLTYFETERSRGWELLEIREIFVECFPTFLATFLFSLIETVPKFAMEGTLPYDYQLYFNTIYFSAQGITMAVGLVYKPQLVRLANIWSNPSHRKRFDLIILAITGVAALITAAMFAFNATVGVALLSLLYGTDFEAYRTQLYLMTIAGGMTAVIDFLYQIITVLRRQETATRIYLIAFGVAGVLSITLVTTIGFDGAVYAYLLSMAALFVMLVVQYVMIRKNG
>NZ_CP012069.2|WP_050344516.1|2089521_2090073_+|glutathione-peroxidase
MVSIYDFTVRDREGKDVSLADYKGKVLIIVNTATECGFTPTYADLQKLYERDKDKDLEILDFPCNQFGQQAPGTADEIHSFCTGRFGVTFPQFGKVEVNGEGADPLFQWLKKQKGFTGFDPTHRITPILTGILDKADPNWRLTPDIKWNFTKFLIDRAGNVVRRFEPTADVDAVVRPAVEELL
>NZ_CP012069.2|WP_050340797.1|2090329_2094841_-|DNA-directed-RNA-polymerase-subunit-beta'
MADFDSTDFDAIKISLASSDEIRKWSRGEVKKPETINYRTLKPEKDGLFCEKIFGPSKDWECSCGKYKGIRFKGIVCERCGVEVTSAKVRRERMGHIELAAPVSHIWYFKSPTSFPLSRLLDIKTKDLEKILYFASYVITSVDAEAREVDAETLKEELAADIEELDAERDDEIERLKAQGEASEAEGIEPLSADEISMGIADLREEYEEEKQLRKEAFNKFMQLEEGELISDESLFTEMRRYYAIYFKGGMGAEAVRELLRSVDLDKEAEELRATVVSEEAQKQRKEKAVKRLEIVDAFLKGGNDPADMILDVIPVIPPDLRPMVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLDAPAIIVNNEKRMLQESVDALFDNGRRGRAVTGRGGRTLKSLAESLKGKQGRFRQNLLGKRVDYSGRSVIVVDPTLKLHQCGLPSSMALELFKPFVMRRLVDLQEIGKLKIDNIKAAKRAIDRRAPEVWDVLDEVIKGRLVLLNRAPTLHRLSIQAFEPVLVDGEAIHLHPLVCAPFNADFDGDQMSAHVPLSTEAQTEARVLMLSINNLRSPASGKVLTVPSQDMVIGTYFLTTAKDGVVGEGRVFSSLADALHAYECSVDEGRQADVSSHNPLDIQAKISVRVSAKDANVEVGGRKYFRVMEDTGGADGKRVEQHDYDVTERPVRFVTTAGRIILNRHCLPTNYPFINYKMSKGDISRLVNDCCDRYSTARIETILDAIKQTGFHYATVAGLSVSVWDAAIPKDKPELIDEAQNKVDRINGLYEKGRLSEIERHGEVVKVWTDCADTLGEKMLTGFSEENPIFMMADSGARGSKTQLRQLAGMRGLMADMSGDTIDLPIKANFREGLQPLEYFISTYGARKGLVDTASHTSDSGYLTRRLVDVAQDVIVREEDCETDEGVTYELIKVEDKKRVKNIDLVGRCVLSDVIDPKTGEVLIAKDNYIGSEADIDLLLEHGIEKVELRALLTCRSKYGVCQKCYGWDLSTRRPVSIGTSVGIIAAQSIGEPGTQLTMRTIHSGGVAGASDITQGLPTVARMFDVVGNVNEKILGREADLAPYTGVLQVTTEQAEKTLRILYPEDHSRILAEWQVPASVSFTPAIKEAVENDQEVEVSAGDQLTEGFVNFRKLRKLTGIESTMHTFVRSVKNVYTSQGVELNDKHIEVIARQMLRRVQVTNPGDSTYLLGQYVDRYAFADTVRNITLAGGVPPEAEPVILGTLKVASSIDSWLSSASFIRTAGVLTESAIKGEVDHLLDLKSNVIVGKKIPAGTGLRAYDDVELTYNGNKLTIAAKADTKPLPESAPDFLKDVEEQLPKKAEWIDGDFGYGGYSKNGRTLTNDEAKLYLYDDLEVSQRWTNKFSEVGIETVGDLIGKTEDDLLRIDGIGAKAIEELRDGLEAHNLLFILEPDEDEADSEDLSQLLNMVFSPDAGNDIMLGSAVPPTHSSDDELIGGSDIKSGDQVINEDLGSLQDLLSQVERGDGDEKLE
>NZ_CP012069.2|WP_157051592.1|2094846_2098305_-|DNA-directed-RNA-polymerase-subunit-beta
MQRERISFSKIPPTMELPNLISVQKESFERFMGEGLSESFAEFSPIEDATKTMEVTFGDHMFGEPPESIASCVAKDFTYKAPMLVGVRFVNKSTGEMKEQLVFMGDFPLMTDRGTFIIKGIERVVVSQLVRSPGVYFARELDNGVEVCRVQFIPARGAWLEFEVDKHGHLVVSIDRKRRQSATVLLRALGIAESDDEILNLLGDSEVVRSTIERDVATNRDDALLEIYRRQRPGEPPTRDNAAALLDGMYFSSQRYDLAKVGRYKINKKLGLDIDATERVLTSEDIVSALRYLLALHDGDPTKTVDDIDHFGNRRVRTVGELVQNQFRIGMSRMERVIRERMVSQDPDDITPNSLINIRPIDAAIKEFFGSSQLSQFMDQANPLSGLTHKRRLSALGPGGLAGHKSGSSRRTNVPTAVRDVHNSHYSRMCPIETPEGPNIGLIGSLALYAHVNRYGFIETPYRRVEAGVVTDTIDWMTADEEESHVIAPATTPVDPATGRFVRTNAEGETVQADYVIARTKNFDGSFGAPAQVDVAEVDYMDVSPRQLLSVAANLIPFLEHDDAKRTLMGANMQRQAVPLIRSHAPLVGTGLERAAAHDSGELICAHEAGTVTEVDASHVVVTSDKTGESERYDLPKYERSNQSTCINHRPVVCLGQKVQMGEVLTDCTSVDHGELALGANLTVAYMPWEGYNYEDGIIVSERVVQEDLLTSINISKHEIEARDTKLGPEEITREIPNQSEEMLANLDDEGIIRIGAEVGPGDILVGKVTPKGETALTAEERLLRAIFGAKAHDVRDTSLRMPHGAYGRVVDVVHFSRDAGAKLSPGTNDQIRVFVAQRRKIQQGDKVAGRHGNKGVVCKVLPVEDMPYMVDGTPVDVLLDPLGVPSRMNVGQLMECHLGWAAAHGWDTESDNSDRVVEGDMLVATPLFDGATDKEVAEALRRTNINMMNRARRDFGEHMRKEFVPQLHEGKTILYDGRTGEPFKNPITVGTSYILKLGHMVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALYAYGASNVLQEILTVKSDDTNGRVKTYEAIVKGENVPAPGIPESFKVLVKEIRSLALDIKPIKYKNPNSVPAAEEVPQDSVEVLSSAESVDDLVGDVADEILAIAADDDKE
>NZ_CP012069.2|WP_050340799.1|2098618_2098996_-|50S-ribosomal-protein-L7/L12
MAVTKEEIIEALKEMPALELSELVHELEDVFGVSAAAPVAVAAAPAAADAAPAEEKTNFDVELTSFGSNKIAVIKVVRALTSYGLKEAKDAVEAAPKVIIEGAKKEDAEAAKKQLEEAGAEVTLK
>NZ_CP012069.2|WP_050340800.1|2099092_2099611_-|50S-ribosomal-protein-L10
MPNKNNVAMLEKVSESLDNSKGVFVIDYRGLSVKETQGLRRALTEAGAHMKVYKNNIVKIALKNAQLPEIENLEGTCAYVFFEKDPVDAAKVIKKQSESLRKIEWVGGIADGNALSAEDARAYADLASREELMAQLVYVVASPLRGIVSVAAGPARGLVTALDALAEQKSAA

Crispr_ID: NZ_CP012069_24

• CRISPR_ID: NZ_CP012069_24
• CRISPR_location: 2296703-2296791
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_24

Consensus_repeat	Method
GCAGCCCCCCCGCCAGGCTGCGGGGC	CRISPRCasFinder

spacers of NZ_CP012069_24

>24.1|2296729|37|NZ_CP012069|CRISPRCasFinder
ACTATGGAGAATGTCTCAACTGGGCAAATGCGCTCGA

CRISPR arrays and Neighbor proteins around NZ_CP012069_24

CRISPR arrays

The CRISPR arrays of NZ_CP012069_24

>merge|NZ_CP012069|24|2296703-2296791|CRISPRCasFinder
GCAGCCCCCCCGCCAGGCTGCGGGGCACTATGGAGAATGTCTCAACTGGGCAAATGCGCTCGAGCAACCCCCCCGCCAGGCTGCGGGGC

>NZ_CP012069|24|21|2296703-2296791|CRISPRCasFinder
GCAGCCCCCCCGCCAGGCTGCGGGGC	ACTATGGAGAATGTCTCAACTGGGCAAATGCGCTCGA
GCAACCCCCCCGCCAGGCTGCGGGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050341035.1|2302146_2303223_+|serine-hydrolase	unknown	unknown	gnl|CDD|379138
NZ_CP012069.2|WP_050341041.1|2307962_2311697_+|phosphoribosylformylglycinamidine-synthase	unknown	unknown	gnl|CDD|130916
NZ_CP012069.2|WP_083443950.1|2290309_2291095_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
NZ_CP012069.2|WP_083443951.1|2305148_2307005_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|275313
NZ_CP012069.2|WP_050344527.1|2303332_2304253_-|UDP-N-acetylmuramate-dehydrogenase	unknown	unknown	gnl|CDD|237553
NZ_CP012069.2|WP_050341010.1|2288116_2288635_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224639
NZ_CP012069.2|WP_050341022.1|2294824_2295322_-|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl|CDD|377139
NZ_CP012069.2|WP_050341029.1|2298584_2299331_+|deoxyribose-phosphate-aldolase	unknown	unknown	gnl|CDD|234784
NZ_CP012069.2|WP_050341039.1|2307004_2307808_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl|CDD|223692
NZ_CP012069.2|WP_050341025.1|2295441_2295867_-|PTS-fructose-transporter-subunit-IIA	unknown	unknown	gnl|CDD|237978
NZ_CP012069.2|WP_050341033.1|2300859_2302059_+|serine-hydrolase	unknown	unknown	gnl|CDD|379138
NZ_CP012069.2|WP_050341018.1|2292998_2293904_-|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID	unknown	unknown	gnl|CDD|377079
NZ_CP012069.2|WP_050341031.1|2299479_2300844_+|PFL-family-protein	unknown	unknown	gnl|CDD|180009
NZ_CP012069.2|WP_050341008.1|2286955_2288113_-|DUF1648-domain-containing-protein	unknown	unknown	gnl|CDD|226657
NZ_CP012069.2|WP_050341012.1|2288691_2290317_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341037.1|2304553_2305141_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|226129
NZ_CP012069.2|WP_050341014.1|2291236_2291461_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341020.1|2293906_2294770_-|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl|CDD|377077
NZ_CP012069.2|WP_157051497.1|2292361_2292802_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341027.1|2296943_2298440_-|tyrosine-protein-phosphatase	unknown	unknown	gnl|CDD|379135

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050341035.1|2302146_2303223_+|serine-hydrolase	gnl|CDD|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.45021e-11
NZ_CP012069.2|WP_083443950.1|2290309_2291095_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.53423e-85
NZ_CP012069.2|WP_083443951.1|2305148_2307005_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|275313	TIGR04520, ECF_ATPase_1, energy-coupling factor transporter ATPase. Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the upstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate].	8.28207e-115
NZ_CP012069.2|WP_050344527.1|2303332_2304253_-|UDP-N-acetylmuramate-dehydrogenase	gnl|CDD|237553	PRK13905, murB, UDP-N-acetylmuramate dehydrogenase.	1.53972e-151
NZ_CP012069.2|WP_050341010.1|2288116_2288635_-|GntR-family-transcriptional-regulator	gnl|CDD|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	2.9323e-27
NZ_CP012069.2|WP_050341022.1|2294824_2295322_-|PTS-sugar-transporter-subunit-IIB	gnl|CDD|377139	pfam03830, PTSIIB_sorb, PTS system sorbose subfamily IIB component.	5.41878e-49
NZ_CP012069.2|WP_050341029.1|2298584_2299331_+|deoxyribose-phosphate-aldolase	gnl|CDD|234784	PRK00507, PRK00507, deoxyribose-phosphate aldolase; Provisional.	5.38037e-92
NZ_CP012069.2|WP_050341039.1|2307004_2307808_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl|CDD|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	4.76615e-38
NZ_CP012069.2|WP_050341025.1|2295441_2295867_-|PTS-fructose-transporter-subunit-IIA	gnl|CDD|237978	cd00006, PTS_IIA_man, PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.	1.65686e-18
NZ_CP012069.2|WP_050341033.1|2300859_2302059_+|serine-hydrolase	gnl|CDD|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	0.000128009
NZ_CP012069.2|WP_050341018.1|2292998_2293904_-|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID	gnl|CDD|377079	pfam03613, EIID-AGA, PTS system mannose/fructose/sorbose family IID component.	4.2274e-90
NZ_CP012069.2|WP_050341008.1|2286955_2288113_-|DUF1648-domain-containing-protein	gnl|CDD|226657	COG4194, COG4194, Predicted membrane protein [General function prediction only].	1.59151e-36
NZ_CP012069.2|WP_050341031.1|2299479_2300844_+|PFL-family-protein	gnl|CDD|180009	PRK05313, PRK05313, hypothetical protein; Provisional.	0
NZ_CP012069.2|WP_050341037.1|2304553_2305141_+|ECF-transporter-S-component	gnl|CDD|226129	COG3601, COG3601, Predicted membrane protein [Function unknown].	1.08216e-20
NZ_CP012069.2|WP_050341020.1|2293906_2294770_-|PTS-sugar-transporter-subunit-IIC	gnl|CDD|377077	pfam03609, EII-Sor, PTS system sorbose-specific iic component.	5.17114e-60
NZ_CP012069.2|WP_050341041.1|2307962_2311697_+|phosphoribosylformylglycinamidine-synthase	gnl|CDD|130916	TIGR01857, FGAM-synthase, phosphoribosylformylglycinamidine synthase, clade II. This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis].	0
NZ_CP012069.2|WP_050341027.1|2296943_2298440_-|tyrosine-protein-phosphatase	gnl|CDD|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	2.19512e-44

Protein sequences

>NZ_CP012069.2|WP_050341025.1|2295441_2295867_-|PTS-fructose-transporter-subunit-IIA
MRYLLVVSHGTFAPGLHSVIRMLAGDRDDVLSCSLEDGMGADVYTERLKKTISPIGQDDTIFLFGDIIGGSPLTNAMDVLTEAGHIDRTTVFGGANVPMVITAALEADNDDQTLKEMVISEGQAAIREFVLDLGGDEDEEL
>NZ_CP012069.2|WP_050341022.1|2294824_2295322_-|PTS-sugar-transporter-subunit-IIB
MISFVRVDDRIIHGQTVTRWALEYPCDGIIGVNDAAANNPVLKAAYKGAAPEKKVFVWTLEHFKESMDKVLASKTKYFLITKNPLDMKTILVDYGFKPSDIDRVIIGPCNDRPGAIKLGNNQSITPEEAQALEDITKAGYTVEFALLKDKSIGEWPQFRSRFDVK
>NZ_CP012069.2|WP_050341020.1|2293906_2294770_-|PTS-sugar-transporter-subunit-IIC
MEINYLQAALLGLCACLASLPGMGGTTVGNYTLGRPLVGGLVVGLILGDVQTGVIVGAAIQIVYIALVTPGGTVSADVRAVTYIGIPLSILAIHANNLDPSSVAASSMAATLGAAVGTLGTVLFYGTATLNLVWQSIGWKALESKDWKKIKRTLPLVDFVYPWVSHILFSFIPTFIICMAGAQMVDLMKEYMPMDGVAMKTLFTVGSLLPTVGVAILCKQVITKSLDWLTFAFGFTLAACMHLNLIACAIVASFFALIKYQIEQAKAARPAVAAAAGAAGDEEEEDI
>NZ_CP012069.2|WP_050341018.1|2292998_2293904_-|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID
MAETKKISPKARKKAFRNWSYGNLTCFSQAHMQTFGYLVAMLPIVDDLYEKDEEKIEALSTYTTFFNTEPQIGTMVIGLTTGLEEARANGEHIDAETINGIRAGLMGPLAGLGDSIVVGTFIPILLGIALGLSSGGSVLGPLFYIVAWNLLMYFGMKLAYNRGYELGGSAVQALVGPESQALRSAIVMVGTMVIGAVAATWISISTALQLPGLGSFDGVLWSSNSTVTQQALEAAGEQGVTLNVFGSGIYPKLLNFLFVYLCWWLMTKKKIGVIPVMLILVGVALVGVLVGFFNPGLSYGG
>NZ_CP012069.2|WP_157051497.1|2292361_2292802_-|hypothetical-protein
MRSTEAGSHEKGATSKGRGASLPARRETLIKEADLQVRAIMRMEAWKRIAYSLVAVGALLAYWQAYRDGPAWALVVGVAVLVVSVLASLILYLVVNRAKMNVRAIMRAAGVDIDTPRSKRDAREGEGAGDASGTGNVDGDTQPPAR
>NZ_CP012069.2|WP_050341014.1|2291236_2291461_-|hypothetical-protein
MAAVGFAPLLATSSYCIAAAVRAQREGAIEHGTMISLIVLHLLFVTDLIASVVLYTKLCRAMWSVSDSPIGTRL
>NZ_CP012069.2|WP_083443950.1|2290309_2291095_-|ABC-transporter-ATP-binding-protein
MGATQNGDSRYATAGWAGGEQPILVVDRYAKSYGGRRAVDGVSLSVGAGSVFGFVGHNGAGKTTLIRSIVGALAFNEGDIRICGRSVRSDPVDCKRVVAYVPDNPDVYGFLTGSQYLNYVADLFGVGVQERRERIAHYAGRLGIDGRLGELVSAYSHGMRQKLVLVGAFLHDPRLLVLDEPFVGLDPEAAYELRTMMQEFVARGGAIFLSSHVLDTVEKLCDEVAIIRRGRIVRVGPTEEVRGDESLEQVFLELAREVRNG
>NZ_CP012069.2|WP_050341012.1|2288691_2290317_-|hypothetical-protein
MGSLAALVKVQAYGAFGIGRLLHSRDARERGRLVISVLGAILLAVLIVANAWSVASALVHIGATDALPSIAVAAVSLGCAVTTFIKANGLLFGFKDFDLVVTMPVPLWQVVVSRVAPLYGMGLATSLVMGAPIMERYIAAVGAPAATVAVAAVVLVLAPLIPIALALALSFCVAWVASRTPFAKGVFSALGALATVALVIGISAASRQAGDSTVMGGEAFATLGRAMGRAMGLVWPPAAWAAKALAGDAVMFCLYAGGSIVLAWVALGVLTHELLGMNALLSSGAAARFGLASSGHTRDLAHAPRTPLVALTLKELRLWVGTPIYFVNTAVGPALTIVIAIVAAVLGPGAVAGTMGVSKSGGEELAKVATLMLPWALAFCTAMTSISASSVSLEGSSRWVMQTAPVADAIIVRSKMALNLALTCAASLVAGLVVAFCFARGPLEALLCVVAPLSGGAISSCLGVFVDVKRPRFDWSSEYEPVKRSTSVLITVGVGMAVVLAGGTLTLGAGGVGAGVAWALVVLVVAALLKRSAERTSLADR
>NZ_CP012069.2|WP_050341010.1|2288116_2288635_-|GntR-family-transcriptional-regulator
MVLYVDQASSSPIYQQIRDQVVAAIARGELRPGDGLPSVRALASDLGVNLHTVHKAYALLRDEGHLLMRGRAGACVADFQQDATPERIVASADKMAGALYRLALEHCARGGTEQEFVVVAQRQAARAFADTDAAGVARDVRVLGLDADGRRRVKGSSSGPEGLVDAQTTQEA
>NZ_CP012069.2|WP_050341008.1|2286955_2288113_-|DUF1648-domain-containing-protein
MESHVVTIVTLSVTILATGALLASTPYLMRQDDSFAVTVPVQAQDDPRIRGLRRCYAIAMLAVTALSVVACVLGGTLLREDAAGGPRPGGGDASTILTCLLGVVPLVPVVASFVLMLCCRRRVLALKRSEGWQATRCISAAVLAEEDVPRAIPLAWSLLYLPVILGTIVLGLALFPHMPDMIPLHADLAGNVDRYVPKTLASAVGLPVATEVFMAFGLTLVHWAILRSKRPVDPAAPATSALSFGLFARAQSVFVLVAGILTDAATGILLTLSAAGLLGLAQAGALLAVCCVPVLMGMVVLSFVYGQGGSRVFGRMRKEAPLLRDDDEHWKLGILYLNRDDASLFLPKRFGIGWTMNFAHPAAWAIILGLIAASALFVALTAMLA
>NZ_CP012069.2|WP_050341027.1|2296943_2298440_-|tyrosine-protein-phosphatase
MVHMGLFGFLGTLQGARKGFGDGTIRIATGINIRELGGFPTAHGKTRYGRFIRSGTTAQVDKADARELYNYGVRRVLDLRGTDEVERSPERLTSLIRVEYLNVPLFDYDITGAGLGRDGDPGGYLTEGIFQMLGNRAAIRDIFTFLAHAPRGSCTLFHCGAGSDRTGLLSLLLLGLAGAERRQIIADYAYSFGYVAEVNAVVFGGSGGAEGLGAVRPDLAVRIKTASTAYDRIVERHGDVRSFLLSCGVRESEVSQVRALLLKRIPPRYRISPEEALVSSTELLHREIPDTESNVRFYVNAYEHPEKVIADLYYMKDKTHDLVARIDASQRDRSFHDHDYVDLLVPEEELGHLYAPVDGKVLPLDQSQDPIFASGQSGRGIVIVPSGNTLYTPAACRVTAQLPSFNAVGLLTQDGIELLVVVGAGAERSDGRGFRQHVWQNDSARRGVPLISWDPTLVPKAAAGQVMLIVTNSSELENVELLESGNVQVGDEIASISP
>NZ_CP012069.2|WP_050341029.1|2298584_2299331_+|deoxyribose-phosphate-aldolase
MGTWTLEELCQLVDHTNLRPDATAADMQRLCDEAASHHFRMVAIEPCQVVRCARLLRGTGVHVGAAIGFPLGQTTVATKVFETREALENGADEIDYVVNRSELKDGKWKQVEDEMSAIVSVCKEARALSKVIFETRELSSEEIIRLCKIASRVRPDFVKTSTGFSPKGGATVRDVRLMCEHVGEGVQVKAAGGIRDADSFLAMVAAGARRIGCTASIPIVEELRRRMDARGIPALELEPSEGTTTDQA
>NZ_CP012069.2|WP_050341031.1|2299479_2300844_+|PFL-family-protein
MAITPEEVAETLSMVSQQNLDLRTLTMGISLHGCACEDMGQMCTKVYDHVTKVAEHLVPVAAELEREYGIPIANRRVSVTPVAQIAAACPDADLTPLAHAMDRAAETLGIDFMGGFSALVQKGMGVTDRHLIDSIPEALAGTRRVCSSVNVASLRAGINMDAVLLMARTVLKAARLTRDSNCYGAAKLVVFSNMVEDSPFMAGAIHGSGEGDAVINVGVSGPGVMAAALQELPASADLMEVAERIKQTAFKITRAGELMSREAARRLGVDKGIVDLSLAPTPAAGDSVAQILEIMGVGECGGPGTTCALALLNDAVKKGGVMASSSVGGLSGAFIPVSEDAGMIHAATSGALCLEKLEAMTSVCSVGLDMIAIPGDTPVEAIAGIIADEMAIGVINAKTTAVRLIPAVGHTEGDVLEFGGLFGSAPVMPVNRFAGSVFAHRGGRFPAPLNSLKN
>NZ_CP012069.2|WP_050341033.1|2300859_2302059_+|serine-hydrolase
MTHANTSDRNRARRRGQPDGRRRPRRPRDPGGQASGIFWDRVSRLVLALRRRLRRPSRRDGGDTHRPAASPLARRWRRLPWQLRALCFAVVIAICVGGLVGLLQGRAGSGGIQGGQAGQAGEGPQAELTDSLSATVGYSTLRATSSTRNLAQGDLTDIERALARLRAEGINASIDLETIDGSLTLSYRETAGYYSASCIKGLYAVALYQRRIDTGKVPLSSVQQTVEQMIENSDNSAYMSLWLRYRNNFLGAWLNDNNVSLGIYDTREDYLKKPYPTSTPEQLRQAWRSMYAYLTSNEGNSASLATFFQERSVSPIKDVLEAKGESNVTSMSKAGWCPKNEGSDDEPASNDAGVVIRSHDEGKSYVVAIMSDASSDLDALKPLIKAVDDFVCNRHGPSA
>NZ_CP012069.2|WP_050341035.1|2302146_2303223_+|serine-hydrolase
MAQGVGKHSIPQPERHTGRIVATIACILVLALGLGVAWALSQGLIGRTAPTEDDRTTTTSTPPPESETGKDTGGGETEPLADGEPTDTPENNQKRTVELPAVLRDVSSDIELSNTKEGFSSSAGYAQLTQAVGGFEDEGHQLSFYLKDLTTGATVSYQADESYYPASSIKGPYVVAVYETLVDTGRTRASSVAGLAESAIVNSDNNAFSKLHDTYGASVFGTWLQSFGFDTSGYGGSHSYRAYYYPYTSATQLAEMWEHMYEYLSSGTDSADYLVSLFEQREVSPIADAVGSKYKSWGKAGWYASKKGQGTRPATVDAGIVFADSKPYLVVAMSDAPSELEALTTVFVGLEDAHRDMA
>NZ_CP012069.2|WP_050344527.1|2303332_2304253_-|UDP-N-acetylmuramate-dehydrogenase
MDSDDHLQDLTWRLRSIVGDDNVALDEPMSKHTSFRIGGPADLFVTPDDIDELRDVIAACRAAGVPHFVLGCGSDLLVADEGYRGVIVSCTKGLVNVAIDGETMACQAGVPLREASEMACELGLSGLEFACGIPGSVGGACFMNAGAYGGCVADVLESVRCLMPDGTQQSLPVEELALGYRASRVRDEGLVVLSATFRLHEGDQDDIRARMDDFTQRRRKKQPLELPSAGSTFKRPEGHFAGKLISDAGLKGYAHGGASVSTKHAGFVVNNGGATAADVHAVIRHVQDEVERQFGVRLEPELRFLG
>NZ_CP012069.2|WP_050341037.1|2304553_2305141_+|ECF-transporter-S-component
MAQNPRVTRHDSHSTTDQAHGWSTKRISITALFCALSAIATLFMEFPILPGVPWLKYDPSGIVALVAGFSFGPATGVVVSTMPYLVHLTTPSGAYGVLMAMLATLSLVVPASLVYRRDTTRRGAVIGMVVGGVICVAICIAGNLVITPLFSPTMTLDKVIGLIVPALLPFNVIKIVLNCVLTGLIYKPISKAFGN
>NZ_CP012069.2|WP_083443951.1|2305148_2307005_+|ATP-binding-cassette-domain-containing-protein
MAILTVTGGAAGTQLMAHVSHVTLLYDGNIQALDDVSLDVRRGERLCILGPNGSGKSTLAGVLAGLLAPDEGEVELAGEQVFSSGQVDFEAYHRARRSLGLVFQNPDDQLVTSIVEEDVAFGPENLGVPSNEIGERVRRELHRVAMEGYAKADPTRLSGGQKQRVAIAGALAMEPQLLVLDEPGALLDVRGRRSILKVMGRLKTDGRAIVHITHFMEEALEADRVIVMRRGRIALEGTPQEVFSHADEIQALGLREPWTARLAGRLRELGVGVGWTCDAERLEGELARVAQRHTRSRSTTTTAENQRTCHAKVHSDLAVSVHEVSYSYHSVDARNDTHPALNGVSLEVKRATNTVIIGQTGSGKSTLLRLLCALELPDVGRIVVDGTDTRDRKGRRALHGHVGYVMQHPERQLFAETVAEDVAFGPKNLHLPKDEVTRRCRRALKLVGLLGLEEASPFELSGGQQRMCAIAGILAMQPNILILDEPTAGLDPRRRGDLSRILRVLQRSGVTIVQVTHSREIAVRADEVIVLDQSRVMTHGTPREVFSYRNETLLHESGLGLPTSLDWARRLRAAGVACAEAPLTLEELAQSIAAGIEGRVPTPRAQAIPAPTSEKAPC
>NZ_CP012069.2|WP_050341039.1|2307004_2307808_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MALRLSIGQYLPGASLIHRLDPRVKVAGALVLMVSVFFITGPVQLAFGYACILGLLALARVPVAKVVESIRPIAVVLLVLAAFNFFLTRTGETIWQTGPLLVTTDGMRVATIYSLRLVIAVLAAALILLTTTPTQLTDAFDACLSPLSRVGLPGHELAMVFSLMLRFIPTIADEAQAILDAQAMRGAPLGEGSLVRRCRAVAPILIALLASSVHHANGLSRALDARCYEGGAVRSHWHPLRMRSADWVALATLIAYVAVLLALGAVA
>NZ_CP012069.2|WP_050341041.1|2307962_2311697_+|phosphoribosylformylglycinamidine-synthase
MVSRVYVEKKPGFDVEARQLERELKDVLSVQGLEGLRLINRYDVEGIDEGLFERCIPTVFSEPQSDTATRMMPEAHGATVFAVEFLPGQFDQRAASASECVQLISQRERPTVASAKLYYLAGALSDTDVAAIKTYVINPVEAREASLDERTTLKTAYPAPADVELLDGFNDLDEEGLQALIAERGLAMSLADLSFCQKYFRNEGRVPTITEIRVIDTYWSDHCRHTTFGTQLTDVRIDDAMVERAFEEYLSMRRDLGRTERPICLMDMGTIGASWLKAKGILTNLDESDEINACTVRVTVDVDGRDEDWLFLFKNETHNHPTEIEPFGGAATCIGGAIRDPLSGRAYVYQAMRVTGAADPLVPVSQTMRGKLPQRKLVCTAAEGYSSYGNQVGLATGQVFELYHAGYAAKRLEIGAVVGATPTRHVRRECPTPGDKVILLGGRTGRDGIGGATGSSKAHNVDSLAQDGAEVQKGNAPEERKLQRLFRRGDACRLIKRCNDFGAGGVAVAVGELADGLSIDLDRVPKKYEGLDGTELAISESQERMAVALAPKDVDEFLGYAREENLEATVIAEVSSEPHLRMSWRGRTIVDVSRAFLASNGALRQQRVHVETQGSWTTPWAGATLAERLQALLTDENVASNKGLAERFDSTIGAASVLMPFGGATQLTPTMAMAAKLPVEGETTSCSGMAWGFNPYLMSANQYSGAYLSVVESVCRLVAAGFERKRAYLSFQEYFERLRDVPERWGKPVAALLGALMAQRDLGVGAIGGKDSMSGSFEDLDVPPTLVSFAAAVGKVAHVTSPELKAAGHDVILVLPRYEADGITPAAASLIDALSLVERLIRSGEALAVSTPGYGCLAETLFKMCVGNQLGLSIHGALHEDALFEPAYGSFVVELAEGASIPRPKEGGCSVMALGTTTAAYVLALDGQALELAPLQEAWEARMEPVFPYRRAGEEVKQLSFDVRDHDGRRRPTPKVKLARPRVVIPVFSGNNCEYDSARAFRAAGAEVTTLVINNLSPQAVAASTRALADEIGRSQIVMIPGGFSGGDEPDGAAKFITAFFRAPAVSEAVRKLLQDRDGLMLGICNGFQALVKLGLVPYGDIVPMTDECATLTFNAIGRHQSRLVNTRIASNLSPWFSACELGDIHSIAISHGEGRFVAPRPLLERLKDTGQIATQYVDASGQPSLDLSVNPNGSMLAIEGITSPDGRILGKMGHSERSTKGTFKNVCGRHFQPIFEGGVSYFA

Crispr_ID: NZ_CP012069_25

• CRISPR_ID: NZ_CP012069_25
• CRISPR_location: 2318180-2318271
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_25

Consensus_repeat	Method
ACGTTCAGGGCCAAGTGGCAGTGCCACT	CRISPRCasFinder

spacers of NZ_CP012069_25

>25.1|2318208|36|NZ_CP012069|CRISPRCasFinder
CACACTGCCACTCGACGTCGAGCGTACCAAGGCGGT

CRISPR arrays and Neighbor proteins around NZ_CP012069_25

CRISPR arrays

The CRISPR arrays of NZ_CP012069_25

>merge|NZ_CP012069|25|2318180-2318271|CRISPRCasFinder
ACGTTCAGGGCCAAGTGGCAGTGCCACTCACACTGCCACTCGACGTCGAGCGTACCAAGGCGGTACGTTCAGGGCCGAGTGGCAGTGCCACT

>NZ_CP012069|25|22|2318180-2318271|CRISPRCasFinder
ACGTTCAGGGCCAAGTGGCAGTGCCACT	CACACTGCCACTCGACGTCGAGCGTACCAAGGCGGT
ACGTTCAGGGCCGAGTGGCAGTGCCACT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_083443951.1|2305148_2307005_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|275313
NZ_CP012069.2|WP_050341065.1|2325809_2327213_+|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl|CDD|224128
NZ_CP012069.2|WP_050341043.1|2312354_2312858_+|hypothetical-protein	unknown	unknown	gnl|CDD|274019
NZ_CP012069.2|WP_050341071.1|2329658_2330831_-|3-phosphoglycerate-dehydrogenase	unknown	unknown	gnl|CDD|240651
NZ_CP012069.2|WP_050341055.1|2318724_2319243_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|181835
NZ_CP012069.2|WP_050344529.1|2322668_2323577_+|peptidoglycan-binding-protein	unknown	unknown	gnl|CDD|366659
NZ_CP012069.2|WP_172674482.1|2323810_2324893_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341067.1|2327217_2328213_+|ribose-phosphate-diphosphokinase	unknown	unknown	gnl|CDD|234929
NZ_CP012069.2|WP_050341039.1|2307004_2307808_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl|CDD|223692
NZ_CP012069.2|WP_050341045.1|2313261_2314383_+|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	unknown	unknown	gnl|CDD|273015
NZ_CP012069.2|WP_050341053.1|2316949_2317819_-|hypothetical-protein	unknown	unknown	gnl|CDD|274737
NZ_CP012069.2|WP_050341059.1|2320475_2321531_+|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl|CDD|177883
NZ_CP012069.2|WP_050341057.1|2319272_2320325_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341048.1|2315037_2316246_+|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II	unknown	unknown	gnl|CDD|181774
NZ_CP012069.2|WP_050341061.1|2321534_2322590_+|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|376322
NZ_CP012069.2|WP_050341037.1|2304553_2305141_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|226129
NZ_CP012069.2|WP_050341069.1|2328436_2329537_+|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl|CDD|379084
NZ_CP012069.2|WP_050341047.1|2314355_2315009_+|riboflavin-synthase	unknown	unknown	gnl|CDD|236455
NZ_CP012069.2|WP_050341050.1|2316281_2316749_+|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl|CDD|234606
NZ_CP012069.2|WP_050341041.1|2307962_2311697_+|phosphoribosylformylglycinamidine-synthase	unknown	unknown	gnl|CDD|130916

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_083443951.1|2305148_2307005_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|275313	TIGR04520, ECF_ATPase_1, energy-coupling factor transporter ATPase. Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the upstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate].	8.28207e-115
NZ_CP012069.2|WP_050341065.1|2325809_2327213_+|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl|CDD|224128	COG1207, GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane].	0
NZ_CP012069.2|WP_050341043.1|2312354_2312858_+|hypothetical-protein	gnl|CDD|274019	TIGR02185, membrane_protein_putative, putative ECF transporter S component, Trep_Strep family. This family consists of strongly hydrophobic proteins about 190 amino acids in length with a strongly basic motif near the C-terminus. If is found in rather few species, but in paralogous families of 12 members in the oral pathogenic spirochaete Treponema denticola and 2 in Streptococcus pneumoniae R6. [Transport and binding proteins, Unknown substrate].	0.000549036
NZ_CP012069.2|WP_050341071.1|2329658_2330831_-|3-phosphoglycerate-dehydrogenase	gnl|CDD|240651	cd12174, PGDH_like_3, Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.	5.02982e-150
NZ_CP012069.2|WP_050341055.1|2318724_2319243_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|181835	PRK09415, PRK09415, RNA polymerase factor sigma C; Reviewed.	5.17308e-29
NZ_CP012069.2|WP_050344529.1|2322668_2323577_+|peptidoglycan-binding-protein	gnl|CDD|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	2.39554e-11
NZ_CP012069.2|WP_050341067.1|2327217_2328213_+|ribose-phosphate-diphosphokinase	gnl|CDD|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	3.37634e-139
NZ_CP012069.2|WP_050341039.1|2307004_2307808_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl|CDD|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	4.76615e-38
NZ_CP012069.2|WP_050341045.1|2313261_2314383_+|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	gnl|CDD|273015	TIGR00326, eubact_ribD, riboflavin biosynthesis protein RibD. This model describes the ribD protein as found in Escherichia coli. The N-terminal domain includes the conserved zinc-binding site region captured in the model dCMP_cyt_deam and shared by proteins such as cytosine deaminase, mammalian apolipoprotein B mRNA editing protein, blasticidin-S deaminase, and Bacillus subtilis competence protein comEB. The C-terminal domain is homologous to the full length of yeast HTP reductase, a protein required for riboflavin biosynthesis. A number of archaeal proteins believed related to riboflavin biosynthesis contain only this C-terminal domain and are not found as full-length matches to this model. [Biosynthesis of cofactors, prosthetic groups, and carriers, Riboflavin, FMN, and FAD].	7.25644e-116
NZ_CP012069.2|WP_050341053.1|2316949_2317819_-|hypothetical-protein	gnl|CDD|274737	TIGR03709, PPK2_rel_1, polyphosphate:nucleotide phosphotransferase, PPK2 family. Members of this protein family belong to the polyphosphate kinase 2 (PPK2) family, which is not related in sequence to PPK1. While PPK1 tends to act in the biosynthesis of polyphosphate, or poly(P), members of the PPK2 family tend to use the terminal phosphate of poly(P) to regenerate ATP or GTP from the corresponding nucleoside diphosphate, or ADP from AMP as is the case with polyphosphate:AMP phosphotransferase (PAP). Members of this protein family most likely transfer the terminal phosphate between poly(P) and some nucleotide, but it is not clear which. [Central intermediary metabolism, Phosphorus compounds].	1.26037e-134
NZ_CP012069.2|WP_050341059.1|2320475_2321531_+|UDP-glucose-4-epimerase-GalE	gnl|CDD|177883	PLN02240, PLN02240, UDP-glucose 4-epimerase.	0
NZ_CP012069.2|WP_050341061.1|2321534_2322590_+|polyprenyl-synthetase-family-protein	gnl|CDD|376322	pfam00348, polyprenyl_synt, Polyprenyl synthetase.	6.95591e-70
NZ_CP012069.2|WP_050341048.1|2315037_2316246_+|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II	gnl|CDD|181774	PRK09311, PRK09311, bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II.	0
NZ_CP012069.2|WP_050341037.1|2304553_2305141_+|ECF-transporter-S-component	gnl|CDD|226129	COG3601, COG3601, Predicted membrane protein [Function unknown].	1.08216e-20
NZ_CP012069.2|WP_050341069.1|2328436_2329537_+|zinc-ribbon-domain-containing-protein	gnl|CDD|379084	pfam13240, zinc_ribbon_2, zinc-ribbon domain. This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.	4.06088e-07
NZ_CP012069.2|WP_050341047.1|2314355_2315009_+|riboflavin-synthase	gnl|CDD|236455	PRK09289, PRK09289, riboflavin synthase.	2.91553e-97
NZ_CP012069.2|WP_050341050.1|2316281_2316749_+|6,7-dimethyl-8-ribityllumazine-synthase	gnl|CDD|234606	PRK00061, ribH, 6,7-dimethyl-8-ribityllumazine synthase; Provisional.	1.79908e-83
NZ_CP012069.2|WP_050341041.1|2307962_2311697_+|phosphoribosylformylglycinamidine-synthase	gnl|CDD|130916	TIGR01857, FGAM-synthase, phosphoribosylformylglycinamidine synthase, clade II. This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis].	0

Protein sequences

>NZ_CP012069.2|WP_050341053.1|2316949_2317819_-|hypothetical-protein
MNIRDFQFDGSERFLMANAVTSVEADEGERAVYAQLTATNTRLMGELQDRLYADGREGLVILLQAMDAAGKDSTIKHVMSGVNPQGVMVHSFKQPSHLELAHDYLWRAITQLPPRGTIGLFNRSYYEDVLIVRVHGLWRDYSLPRRCLHCSEDEFFGRRYRQIRDLEEYLYENGYRVLKVFLNVSKDEQRRRFLARIDNERKNWKFSAADVEERKLWSSYMDAYEQAINATSTRHAPWHVIPADQKWLARWLVSEAIVDVLRQMDPRYPTLLAAAKRELEEDRARLMGE
>NZ_CP012069.2|WP_050341050.1|2316281_2316749_+|6,7-dimethyl-8-ribityllumazine-synthase
MTSYEGRLYADDIKIGIVNARFNEFITSKLLSGALDGLARRGVPEDQVDVAWVPGAFEIPVIASRMAQSGKYDAIICLGAVIRGATSHYEAVVNEVSKGIAHIALSTGIPVMFGVLTTESIEQAIERAGSKAGNKGSECAEGAIEMVNLIRSMGI
>NZ_CP012069.2|WP_050341048.1|2315037_2316246_+|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II
MVNERRAGYNLIPEALEALRAGRVILCIDDPDRENEGDFICAAEFATTENVNLMASVAKGLICMPMSEEYVRRLRLPQMVNNNTDNHETAFTVSIDHIDTTTGISAEERGYTARKCTEEGTQPEDFRRPGHMFPLLAKRHGVLVRNGHTEATVDLLRLAGLKQVGLCCEVMREDGTMMRTSELLALAHAHDMPVITIKDLQEYRKYHDKLVSCEASPLLPTSYGEFRACGYVNEVNGEHHVALVKGDIGDGEDVLVRVHSECLTGDVFGSLRCDCGDQLHSAMRQVDAAGRGIVLYMRQEGRGIGLINKLKAYELQQQGMDTVEANLALGFEPDAREYYIGAQILRDLGVRTMRLLTNNPDKVYQLEEFGLRITERVPIQVDANDFDRTYLRTKRDKMGHLL
>NZ_CP012069.2|WP_050341047.1|2314355_2315009_+|riboflavin-synthase
MFTGIVEEVGTIARIQGGAHSSTLEVCARTVWEDTHVGDSICTSGVCLTVTSLTQRGFTADVMHETLSRSTLGGLSVGDKVNLERAMAVGERFGGHIVSGHIDGTGTVEHITRDGTAIWYEIETTPGILRLIIEKGSIALDGISLTVARVDDATNTFSVSTIPHTTTHTTLTDTQVGDAVNLENDIVGKYIERLMRAGNSAATPQGITMDFLLENGF
>NZ_CP012069.2|WP_050341045.1|2313261_2314383_+|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD
MSDEAYMARALRLAALGRGWTNPNPMVGAVIVSGTHVLAEGYHHRYGDLHAERDALKNAMRKGLDVCGATMYVTLEPCCHFGRQPPCTDAIIEAGITRVVIGSSDPNPKVAGQGIGILREAGIEVSEGVLADKCLALNEAFLTYIQTGRPLVTMKYAMTIDGKIACVTGESRWITGEGARRHVHEQRHAAAAIMVGVGTVITDNPQLTSRIEGGNDPVRIVCDTHLRTPLDARVVTSARRVPTLIATCESDPDKHRPFTAAGCQIATLPNRNGHVDLVSLVDELGNRNLDSLIIEGGATLNWSALQAGIVDKVQAYIAPKIFGGMLAQGPVGGPGFTTPADAIELTDVRLTRIGDDHLIEGRILPCSRESSKR
>NZ_CP012069.2|WP_050341043.1|2312354_2312858_+|hypothetical-protein
MARKSKGGKGRVDVKGELVLTALMFAGIFLIAFALRTFLHLGDIYAPVFTAIIAGIIIFFLYRQSQRQRWERENADAERTVNPIIERYAKHRDARRLVHDFDAWDQDAHEADLRLQFLQVAIEALISDGHRRKARSLLDKMGRIAADTGNDQAFASYKASIDARLDG
>NZ_CP012069.2|WP_050341041.1|2307962_2311697_+|phosphoribosylformylglycinamidine-synthase
MVSRVYVEKKPGFDVEARQLERELKDVLSVQGLEGLRLINRYDVEGIDEGLFERCIPTVFSEPQSDTATRMMPEAHGATVFAVEFLPGQFDQRAASASECVQLISQRERPTVASAKLYYLAGALSDTDVAAIKTYVINPVEAREASLDERTTLKTAYPAPADVELLDGFNDLDEEGLQALIAERGLAMSLADLSFCQKYFRNEGRVPTITEIRVIDTYWSDHCRHTTFGTQLTDVRIDDAMVERAFEEYLSMRRDLGRTERPICLMDMGTIGASWLKAKGILTNLDESDEINACTVRVTVDVDGRDEDWLFLFKNETHNHPTEIEPFGGAATCIGGAIRDPLSGRAYVYQAMRVTGAADPLVPVSQTMRGKLPQRKLVCTAAEGYSSYGNQVGLATGQVFELYHAGYAAKRLEIGAVVGATPTRHVRRECPTPGDKVILLGGRTGRDGIGGATGSSKAHNVDSLAQDGAEVQKGNAPEERKLQRLFRRGDACRLIKRCNDFGAGGVAVAVGELADGLSIDLDRVPKKYEGLDGTELAISESQERMAVALAPKDVDEFLGYAREENLEATVIAEVSSEPHLRMSWRGRTIVDVSRAFLASNGALRQQRVHVETQGSWTTPWAGATLAERLQALLTDENVASNKGLAERFDSTIGAASVLMPFGGATQLTPTMAMAAKLPVEGETTSCSGMAWGFNPYLMSANQYSGAYLSVVESVCRLVAAGFERKRAYLSFQEYFERLRDVPERWGKPVAALLGALMAQRDLGVGAIGGKDSMSGSFEDLDVPPTLVSFAAAVGKVAHVTSPELKAAGHDVILVLPRYEADGITPAAASLIDALSLVERLIRSGEALAVSTPGYGCLAETLFKMCVGNQLGLSIHGALHEDALFEPAYGSFVVELAEGASIPRPKEGGCSVMALGTTTAAYVLALDGQALELAPLQEAWEARMEPVFPYRRAGEEVKQLSFDVRDHDGRRRPTPKVKLARPRVVIPVFSGNNCEYDSARAFRAAGAEVTTLVINNLSPQAVAASTRALADEIGRSQIVMIPGGFSGGDEPDGAAKFITAFFRAPAVSEAVRKLLQDRDGLMLGICNGFQALVKLGLVPYGDIVPMTDECATLTFNAIGRHQSRLVNTRIASNLSPWFSACELGDIHSIAISHGEGRFVAPRPLLERLKDTGQIATQYVDASGQPSLDLSVNPNGSMLAIEGITSPDGRILGKMGHSERSTKGTFKNVCGRHFQPIFEGGVSYFA
>NZ_CP012069.2|WP_050341039.1|2307004_2307808_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MALRLSIGQYLPGASLIHRLDPRVKVAGALVLMVSVFFITGPVQLAFGYACILGLLALARVPVAKVVESIRPIAVVLLVLAAFNFFLTRTGETIWQTGPLLVTTDGMRVATIYSLRLVIAVLAAALILLTTTPTQLTDAFDACLSPLSRVGLPGHELAMVFSLMLRFIPTIADEAQAILDAQAMRGAPLGEGSLVRRCRAVAPILIALLASSVHHANGLSRALDARCYEGGAVRSHWHPLRMRSADWVALATLIAYVAVLLALGAVA
>NZ_CP012069.2|WP_083443951.1|2305148_2307005_+|ATP-binding-cassette-domain-containing-protein
MAILTVTGGAAGTQLMAHVSHVTLLYDGNIQALDDVSLDVRRGERLCILGPNGSGKSTLAGVLAGLLAPDEGEVELAGEQVFSSGQVDFEAYHRARRSLGLVFQNPDDQLVTSIVEEDVAFGPENLGVPSNEIGERVRRELHRVAMEGYAKADPTRLSGGQKQRVAIAGALAMEPQLLVLDEPGALLDVRGRRSILKVMGRLKTDGRAIVHITHFMEEALEADRVIVMRRGRIALEGTPQEVFSHADEIQALGLREPWTARLAGRLRELGVGVGWTCDAERLEGELARVAQRHTRSRSTTTTAENQRTCHAKVHSDLAVSVHEVSYSYHSVDARNDTHPALNGVSLEVKRATNTVIIGQTGSGKSTLLRLLCALELPDVGRIVVDGTDTRDRKGRRALHGHVGYVMQHPERQLFAETVAEDVAFGPKNLHLPKDEVTRRCRRALKLVGLLGLEEASPFELSGGQQRMCAIAGILAMQPNILILDEPTAGLDPRRRGDLSRILRVLQRSGVTIVQVTHSREIAVRADEVIVLDQSRVMTHGTPREVFSYRNETLLHESGLGLPTSLDWARRLRAAGVACAEAPLTLEELAQSIAAGIEGRVPTPRAQAIPAPTSEKAPC
>NZ_CP012069.2|WP_050341037.1|2304553_2305141_+|ECF-transporter-S-component
MAQNPRVTRHDSHSTTDQAHGWSTKRISITALFCALSAIATLFMEFPILPGVPWLKYDPSGIVALVAGFSFGPATGVVVSTMPYLVHLTTPSGAYGVLMAMLATLSLVVPASLVYRRDTTRRGAVIGMVVGGVICVAICIAGNLVITPLFSPTMTLDKVIGLIVPALLPFNVIKIVLNCVLTGLIYKPISKAFGN
>NZ_CP012069.2|WP_050341055.1|2318724_2319243_+|sigma-70-family-RNA-polymerase-sigma-factor
MRQRSGEFMQTAMDSWGDIVYRVALSQTCSHQDAQDVAQDVFLRLLTSPVEFEDGEHLKAWLLRATINRCRELHRSWWKRRVQGAGDAEAEAFANASALADSSPTEEAALRAVERHPIWQALRKLPDQLRATVTLHYIEGISCAQIARIMECRPATVRTRLRRARTKLRGLL
>NZ_CP012069.2|WP_050341057.1|2319272_2320325_+|hypothetical-protein
MDERRTVDELRSLMRQVHLPGAVRENVLLEAAHPDVAEPTGASTKRRQLITRRSALRLGLAAASVAATFVGLSMHGVPHKGEQAPKEAGSGSFVLVAYAEGTRQDDEVILSVDDFGTKSSSWSEGDKGSLGVSRSLSLNCTGNAIKKLAYSLEGAFAYLPQDDETSRSYVFFDAIVKGPLHEYGGTDAGSSCTNFTLAYDQLAQDKESFGRSVRAHFPASAELTSALQSLKQYNPTREDSRSPDAIRAYCEANRTVALYSEKTYAELLSQTPLVITATFEDDSTKTKRYVIAPIADFERVYGDWLERLTELEVKMELGSDNDQVARDEAEARYVEQLSAQPQLYTIREEA
>NZ_CP012069.2|WP_050341059.1|2320475_2321531_+|UDP-glucose-4-epimerase-GalE
MSEQKAPADSCVLVTGGAGFIGSHTVVELLERGYRVVVVDDLSNASEKVLDRIGKITGEKAAARLSFYQADVSDRAALEAVFAANDIDYVIHFAGFKAVGESVLKPVEYYSNNLNTTLTLVDVMRAHGCRSIIFSSSATVYGDPDALPLTEESPKKSATNPYGWTKWMIEQILSDLHVANPAWNVVLLRYFNPIGAHPSGLMGEDPKGIPNNLLPYVAQVAVGKRDTVRVFGDDYDTPDGTGVRDYIHVMDLASGHVAALAWMAGRTGVEVFNLGTGRGTSVLEIIKAFSKACGRDLPYVIEPRRAGDVTANYADCSKAKREMGWEATYDIDDMCRDGWNWQSMNPNGYED
>NZ_CP012069.2|WP_050341061.1|2321534_2322590_+|polyprenyl-synthetase-family-protein
MPSNTTDKGAAFRAYLAKKRPLIEAYLSEHAPAPLGDETVVGDDLERYLYGPLKRFMASGGKRTRPVLVLLGCEAVGGTATSALSCACAIEDFQSAALIHDDIADKGTLRRGAPCMHVTEGVGIAINVADLALIIAQSRILRERSLSPELRVRILEEFAAMEERTLEGQALDLGWVRDGRWDLSVDDYLCMASHKTAFYSAACPLSIGAICGGGTDEQVEALRTFGMGAGLAFQLQDDLLNLVGNAKTQGKDFRSDITEGKHTMAVTWSLERLQNSQRDELIEILTSHATDAATLERAVGLMESVGAIEGVRDYAHSVAESARRELDGIELADDMCTILDSMADFFVERTG
>NZ_CP012069.2|WP_050344529.1|2322668_2323577_+|peptidoglycan-binding-protein
MEAIREGASGVAVEDIQDRLTSLGYEIDGDEASSTTFGPSTAQAVAKFRLDHNMSLGTEIDFATWMALVDECYQLGDRTLYLRLPNFHGHDVKQLQERLNILGFSCGKPDGCYGVHTESAVKEFQESQGALADGMAFQDTFDDIERLHHVWAGKSAAGPHPIGGVGYARAAGVLENTQISLTGEDPIARNVAGRIWNLATATSDKSCLDLIDSVELARDDTIVIVLASSPLPKRSKMANIVMDDIKTLPQRLRTACESFRKSTPIVRIELPLGLNYDGTFTTGDAQTFAVTVLDAICTAFDH
>NZ_CP012069.2|WP_172674482.1|2323810_2324893_-|hypothetical-protein
MRGESCGVTNKAVADDRTVLYAGDFALECWRRSPRNTVPSALMVRGFSLERCTADAIVLRTLSLRQFDSIGVEPEVIVGHQNRRTRRQGVRCRCLSTRLAPGSVCGFGKAMILSPEACFVESANDMSFIRLVELGLELCGTYSLDWKTRKGFRERTPLTSVQRILRLLDGMDSGVRGIRRAKRALAWVRDGSASPKESQLIMALTLPTAIGGFGMPVPQINYPIPLGRKDVLRGSPTHYRVDLYWPEVRVSVEYQSDSEHTGDPEKTYQDQGRRDELLSMGVRQLCFNASHMRHAGSFEKQVERLSALIHTTFPERGALDKERFGMLLAWLGRPQHMHPNLDEREVPELLRGVPRNGGKA
>NZ_CP012069.2|WP_050341065.1|2325809_2327213_+|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MPSTAIILAAGKGTRMKSRHPKVMHRLLDRPLAWWAVRSARQAGMERIVLVVGSGAQEVRDYFAADGDADASIEFVEQKERLGTGHAVRCVRDALGELKGPVVVMYADMPLVHPQTIRSLVSEARAKHNACTVLSMTPPDPSDYGRVDASDDGTVRAIIEHEDCTPEQREALRECNSGLYCFCGRRLFANIDRITNDNAQGEYYLTDMVGIYVGMGEPVSVVHADDYHELLGVNSRSQLAVAAKVMQRRINEGLMAEGVSMLDPEQVWVGAEVRVGQDTTLLPQTFLWGRTIVGSDCTIGPNSRLTNATVGDRCLVDETIIVDSAIDNDVSCGPRAYLRGGAHFHDRSKAGTHVELKGTEVGVGSKVPHLSYLGDARLGSGVNIGGGTITCNYDGKHKSRTEIGDHVFIGSDVMLVAPVTIGDNALVGAASCITKDVPAGALSLERSRQLTQRGWADAYWKRLEEED
>NZ_CP012069.2|WP_050341067.1|2327217_2328213_+|ribose-phosphate-diphosphokinase
MYENLSRPRLYEKEIKLYSGTSNPALSARIANILGLKLQGLKLEKFSNGEIYARFEESVRGDEVFFIQSIVGKNINDMLMETLVVADAASRASAKSFTAVLPHYGYARQDRKAASREPITARLIANLLEIAGVDRVIALDLHSGQIQGFFDVPVTHLTALYLFGDYFRAKDFDWADTVVVSPDMGRAKVAKKLSDYLGCEVAIAHKSRPKHNTAEVMGIIGNIVGKTCIINDDMIDTGGTLVGSITKLKEMGAGDIYVSATHGIFSGQAIERLERAPIVECVVTDAIPCAVANTPGSKIKQISVAESLALCIYNVYMDNPVSEGHSGNSEM
>NZ_CP012069.2|WP_050341069.1|2328436_2329537_+|zinc-ribbon-domain-containing-protein
MGENRFCTNCGAELVEDATFCVNCGQPVEVADTSPTKTAAMPNLQEAFPETQSEPAYSQQPATDPFEPMGAPFQPSVSTVSGAAQYAVPNAPSPAQYAVPVSPPAATPIPTATQAPKDSSKIFTTVSIVIITLSLVASVGALIYLFMPTPNNALQQQGAAVSNGASGNANNSGGNTGTNGNSNSGSGTNGNTNPTQPTTPNTTNTPSTTNTNPTPNTTTSQQQADSQFRSELVSYYNRLSGYDSRIASAADTFNHNFLSSSMSTRQSYASSCSSLLSEVQQQSNAVSSLSVPSGSAYAEQYRLIRQCYQDLVERADCLNRGWQISISYSNPSAHEDEILEPIRSNASGGNNIYYTDYNNTYPKIKL
>NZ_CP012069.2|WP_050341071.1|2329658_2330831_-|3-phosphoglycerate-dehydrogenase
MYNIHCMNNIAKVGTDRLAEGYRFVDDLDEADAIMVRSANLLELSFPTRLLAIARAGAGVNNIPLERCAKEGIVVFNTPGANANAVKELVFCGMLLASRDIIGGNEWVRENCDDPDLVRKTEKAKKRFAGVELAGKRLGVIGLGAIGAVVANTATRFGMEALGYDPHLSINAAWGLDRRIRHVTDINEIFRECDYITIHVPATDETRGMIGADAIRQMKRGVVVLNLARDVLVDEQAMAEALDDGLVARYVCDFPNPATANMKNAIVLPHLGASTAEAEDNCAIMAASELKNYLENGTINHSVNYGTVDLGPLSAGRARLCLFHQNMQGLIGKISATLTESNLNIENMSNKSCGGSAYTLIEVTGDAADSSVGELSQIRGMRRVRLIPPS

Crispr_ID: NZ_CP012069_26

• CRISPR_ID: NZ_CP012069_26
• CRISPR_location: 2441294-2441379
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_26

Consensus_repeat	Method
GCCCCGCAGCCTGGCGGGCGGTTG	CRISPRCasFinder

spacers of NZ_CP012069_26

>26.1|2441318|38|NZ_CP012069|CRISPRCasFinder
CTCGAGCGCATTTGCCCAGTTGAGCCTCTTTTCATAGT

CRISPR arrays and Neighbor proteins around NZ_CP012069_26

CRISPR arrays

The CRISPR arrays of NZ_CP012069_26

>merge|NZ_CP012069|26|2441294-2441379|CRISPRCasFinder
GCCCCGCAGCCTGGCGGGCGGTTGCTCGAGCGCATTTGCCCAGTTGAGCCTCTTTTCATAGTGCCCCGCAGCCTGGCGGGCGGTTG

>NZ_CP012069|26|23|2441294-2441379|CRISPRCasFinder
GCCCCGCAGCCTGGCGGGCGGTTG	CTCGAGCGCATTTGCCCAGTTGAGCCTCTTTTCATAGT
GCCCCGCAGCCTGGCGGGCGGTTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_157051510.1|2450005_2450308_+|hypothetical-protein	unknown	unknown	gnl|CDD|273806
NZ_CP012069.2|WP_050341256.1|2433863_2434607_-|NAD-dependent-protein-deacylase	unknown	unknown	gnl|CDD|234777
NZ_CP012069.2|WP_050341278.1|2450458_2450788_-|glutathione-S-transferase-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|366113
NZ_CP012069.2|WP_050341257.1|2434763_2435750_+|patatin-family-protein	unknown	unknown	gnl|CDD|132847
NZ_CP012069.2|WP_172674490.1|2438563_2439826_-|NINE-protein	unknown	unknown	gnl|CDD|377473
NZ_CP012069.2|WP_157051509.1|2443119_2444217_+|PASTA-domain-containing-protein	unknown	unknown	gnl|CDD|153057
NZ_CP012069.2|WP_050341248.1|2427755_2430557_+|ABC-transporter-ATP-binding-protein/permease	unknown	unknown	gnl|CDD|213222
NZ_CP012069.2|WP_050341271.1|2447352_2448471_-|serine-hydrolase	unknown	unknown	gnl|CDD|379138
NZ_CP012069.2|WP_050341252.1|2431378_2432182_+|type-III-pantothenate-kinase	unknown	unknown	gnl|CDD|237347
NZ_CP012069.2|WP_050341259.1|2436872_2437691_-|phosphatase	unknown	unknown	gnl|CDD|213992
NZ_CP012069.2|WP_050341279.1|2450853_2451237_-|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl|CDD|223317
NZ_CP012069.2|WP_050341273.1|2449095_2449902_+|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl|CDD|273806
NZ_CP012069.2|WP_050341250.1|2430684_2431146_-|50S-ribosomal-protein-L31	unknown	unknown	gnl|CDD|376487
NZ_CP012069.2|WP_172674491.1|2440230_2441079_-|SPOR-domain-containing-protein	unknown	unknown	gnl|CDD|379084
NZ_CP012069.2|WP_083443964.1|2444295_2445690_+|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|225217
NZ_CP012069.2|WP_050341254.1|2432259_2433711_-|dihydropteroate-synthase	unknown	unknown	gnl|CDD|273657
NZ_CP012069.2|WP_050341263.1|2441791_2443048_+|hypothetical-protein	unknown	unknown	gnl|CDD|366376
NZ_CP012069.2|WP_083443961.1|2435819_2436722_+|exodeoxyribonuclease-III	unknown	unknown	gnl|CDD|197321
NZ_CP012069.2|WP_172674529.1|2451283_2453053_-|aspartate--tRNA-ligase	unknown	unknown	gnl|CDD|234775
NZ_CP012069.2|WP_083443965.1|2446023_2447217_+|NINE-protein	unknown	unknown	gnl|CDD|377473

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_157051510.1|2450005_2450308_+|hypothetical-protein	gnl|CDD|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	0.00161021
NZ_CP012069.2|WP_050341256.1|2433863_2434607_-|NAD-dependent-protein-deacylase	gnl|CDD|234777	PRK00481, PRK00481, NAD-dependent deacetylase; Provisional.	7.82129e-106
NZ_CP012069.2|WP_050341278.1|2450458_2450788_-|glutathione-S-transferase-N-terminal-domain-containing-protein	gnl|CDD|366113	pfam00462, Glutaredoxin, Glutaredoxin.	1.77492e-17
NZ_CP012069.2|WP_050341257.1|2434763_2435750_+|patatin-family-protein	gnl|CDD|132847	cd07208, Pat_hypo_Ecoli_yjju_like, Hypothetical patatin similar to yjju protein of Escherichia coli. Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	4.0912e-58
NZ_CP012069.2|WP_172674490.1|2438563_2439826_-|NINE-protein	gnl|CDD|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	1.16049e-16
NZ_CP012069.2|WP_157051509.1|2443119_2444217_+|PASTA-domain-containing-protein	gnl|CDD|153057	cd00037, CLECT, C-type lectin (CTL)/C-type lectin-like (CTLD) domain. CLECT: C-type lectin (CTL)/C-type lectin-like (CTLD) domain; protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. This group is chiefly comprised of eukaryotic CTLDs, but contains some, as yet functionally uncharacterized, bacterial CTLDs. Many CTLDs are calcium-dependent carbohydrate binding modules; other CTLDs bind protein ligands, lipids, and inorganic surfaces, including CaCO3 and ice. Animal C-type lectins are involved in such functions as extracellular matrix organization, endocytosis, complement activation, pathogen recognition, and cell-cell interactions. For example: mannose-binding lectin and lung surfactant proteins A and D bind carbohydrates on surfaces (e.g. pathogens, allergens, necrotic, and apoptotic cells) and mediate functions associated with killing and phagocytosis; P (platlet)-, E (endothelial)-, and L (leukocyte)- selectins (sels) mediate the initial attachment, tethering, and rolling of lymphocytes on inflamed vascular walls enabling subsequent lymphocyte adhesion and transmigration. CTLDs may bind a variety of carbohydrate ligands including mannose, N-acetylglucosamine, galactose, N-acetylgalactosamine, and fucose. Several CTLDs bind to protein ligands, and only some of these binding interactions are Ca2+-dependent; including the CTLDs of Coagulation Factors IX/X (IX/X) and Von Willebrand Factor (VWF) binding proteins, and natural killer cell receptors. C-type lectins, such as lithostathine, and some type II antifreeze glycoproteins function in a Ca2+-independent manner to bind inorganic surfaces. Many proteins in this group contain a single CTLD; these CTLDs associate with each other through several different surfaces to form dimers, trimers, or tetramers, from which ligand-binding sites project in different orientations. Various vertebrate type 1 transmembrane proteins including macrophage mannose receptor, endo180, phospholipase A2 receptor, and dendritic and epithelial cell receptor (DEC205) have extracellular domains containing 8 or more CTLDs; these CTLDs remain in the parent model. In some members (IX/X and VWF binding proteins), a loop extends to the adjoining domain to form a loop-swapped dimer. A similar conformation is seen in the macrophage mannose receptor CRD4's putative non-sugar bound form of the domain in the acid environment of the endosome. Lineage specific expansions of CTLDs have occurred in several animal lineages including Drosophila melanogaster and Caenorhabditis elegans; these CTLDs also remain in the parent model.	3.07677e-28
NZ_CP012069.2|WP_050341248.1|2427755_2430557_+|ABC-transporter-ATP-binding-protein/permease	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.29212e-67
NZ_CP012069.2|WP_050341271.1|2447352_2448471_-|serine-hydrolase	gnl|CDD|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	6.0945e-64
NZ_CP012069.2|WP_050341252.1|2431378_2432182_+|type-III-pantothenate-kinase	gnl|CDD|237347	PRK13318, PRK13318, type III pantothenate kinase.	3.68708e-92
NZ_CP012069.2|WP_050341259.1|2436872_2437691_-|phosphatase	gnl|CDD|213992	cd07437, PHP_HisPPase_Ycdx_like, Polymerase and Histidinol Phosphatase domain of Ycdx like. PHP Ycdx-like is a stand alone PHP domain similar to Ycdx E. coli protein with an unknown physiological role. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. It has also been shown that the PHP domain functions in DNA repair. The PHP structures have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel. YcdX may be involved in swarming.	3.86592e-103
NZ_CP012069.2|WP_050341279.1|2450853_2451237_-|fluoride-efflux-transporter-CrcB	gnl|CDD|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	3.83618e-28
NZ_CP012069.2|WP_050341273.1|2449095_2449902_+|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl|CDD|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	6.99099e-15
NZ_CP012069.2|WP_050341250.1|2430684_2431146_-|50S-ribosomal-protein-L31	gnl|CDD|376487	pfam01197, Ribosomal_L31, Ribosomal protein L31.	8.00413e-39
NZ_CP012069.2|WP_172674491.1|2440230_2441079_-|SPOR-domain-containing-protein	gnl|CDD|379084	pfam13240, zinc_ribbon_2, zinc-ribbon domain. This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.	1.07455e-05
NZ_CP012069.2|WP_083443964.1|2444295_2445690_+|PrsW-family-intramembrane-metalloprotease	gnl|CDD|225217	COG2339, prsW, Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones].	9.71626e-25
NZ_CP012069.2|WP_050341254.1|2432259_2433711_-|dihydropteroate-synthase	gnl|CDD|273657	TIGR01496, Dihydropteroate_synthase, dihydropteroate synthase. This model represents dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis. The gene is usually designated folP (folic acid biosynthsis) or sul (sulfanilamide resistance). This model represents one branch of the family of pterin-binding enzymes (pfam00809) and of a cluster of dihydropteroate synthase and related enzymes (COG0294). Other members of pfam00809 and COG0294 are represented by model TIGR00284. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid].	6.17808e-92
NZ_CP012069.2|WP_050341263.1|2441791_2443048_+|hypothetical-protein	gnl|CDD|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	4.52728e-74
NZ_CP012069.2|WP_083443961.1|2435819_2436722_+|exodeoxyribonuclease-III	gnl|CDD|197321	cd09087, Ape1-like_AP-endo, Human Ape1-like subfamily of the ExoIII family apurinic/apyrimidinic (AP) endonucleases. This subfamily includes human Ape1 (also known as Apex, Hap1, or Ref-1) and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Ape1 and Ape2 in humans. Ape1 is found in this subfamily, it exhibits strong AP-endonuclease activity but shows weak 3'-5' exonuclease and 3'-phosphodiesterase activities. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes exonuclease III (ExoIII) and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	1.3422e-139
NZ_CP012069.2|WP_172674529.1|2451283_2453053_-|aspartate--tRNA-ligase	gnl|CDD|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP012069.2|WP_083443965.1|2446023_2447217_+|NINE-protein	gnl|CDD|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	1.18776e-18

Protein sequences

>NZ_CP012069.2|WP_172674491.1|2440230_2441079_-|SPOR-domain-containing-protein
MATGEFCTNCGAQLDRDAQFCVSCGQSRQDDEGQRAAVANATVVQEPVQASVDPTASTDPSVPCGAVDHAFPIQTASPVSVRTGAERAEPDRTGRGGRGPVIAATVAIVFSVLSISLSLLYLFVWPAATNRIASVGWQQEQSSDADLTSSSPSENAGSKSSGSASDQGAAASGAPKNSPTEGERDPGYRTGYHEPFWGVWTFASKSASEAMERATSMTAKGFDSTVELTTDWSNLNDEEWYVVTTGMWRDREEAESMASSLRLAGYSDAYAKYSGEYVGDKR
>NZ_CP012069.2|WP_172674490.1|2438563_2439826_-|NINE-protein
MFCTRCGNSLPANARFCSRCGNPVFGVQPVVPVAPTTALATQSTTSYHPRQSTISDTYPTVPVAASDVAQVATTLAQVDVSATATVPVAEVSAAVPSLVEGAVSETVGERAARDKPVSASGPAPTYIPVAKDREAMPTVTDDSFPAEGAALPAAPREPPTMKTVVANDPDQTVTGVVYTETRTAGEVERGIVEEASKGEEETAVSQSDGLGAKNALEDANTNKETGSYTALAKAIPEDRARGARRLTDDELARLSIEVTELRKSMKKIQQLLLSSGAITPAQYCRAMYGSPSPHGSPLSPSAADQSFPQVSVSAQASYDQTQVLTVPSTQTASVRRTDSEKGRLAAGLLAIFLGGLGVHKFYLGYTGAGVAMLLISIFGAVILIGPILMGLCGLIEGIIYLTKSDEDFQRTYVWGDKPWF
>NZ_CP012069.2|WP_050341259.1|2436872_2437691_-|phosphatase
MLHIRCDTHTHTIYSRHAYSTVEENVRAAAELGIGLLGSTDHYSSMLFPEVEDTRRAHVHDLRDHQYFINYHCWPREWCGVRLLHGCEADIVDLEGHLFGWDVAVDREINGTLLPESTTLKERVFKDCDYVIASVHNDDFTKGATLAKTTEMYLRALEDPKVLILGHLGRSGVPFDVDAVLMSARERGKMVEINEATLANHTEAAASCRAIASRAAELGCMVSTGSDAHISYDVGRLGRVRGLLEDLHFPQELIATTDADSFLEALRRAVVP
>NZ_CP012069.2|WP_083443961.1|2435819_2436722_+|exodeoxyribonuclease-III
MRPGVAARKSGAPRPSLSTRHNFPAEGDIVSDTPSTPTTDSDTDASELTLVSWNVNGLRAVLKKEPSFAEVFNSCSADVFAIQETKLQEGQVDLDIPGYVQTWSFAKRKGYSGTAVFSREEPLQVVRQIGSPVAEDEGRVCALEFTGYWFVNVYTPNSKNGLARLDERMLWDERYRSFLAGLAKEKPVVSCGDFNVAHEEIDLKNPDTNHQNAGFSDQEREGFTRLLDAGFTDSFRKLYPDRADAYSWWSYRMRARERNVGWRIDYFLVSDDAAGRITGASILDDVYGSDHCPVELRIRL
>NZ_CP012069.2|WP_050341257.1|2434763_2435750_+|patatin-family-protein
MTALDTNISDCALVFEGGGYRGAYTAGFARVLLEQQFHFGFVCGLSAGASHTVDYTSRDLHRTRAAFLARKPAGVQIGGIRSIVQGTGLFNADYLYAGCVEDGFLPFDWETFCANPAQIRIQTFERDTGRTVTFGKEDMPDVMTMINLVRASSTLPGAMKPLPVNGRVLLDGGLGKGAGIPVRLAEEAGYRRFFFVATRPKGYRKQPPTKRELRMQNLVSRDYPYLRNAMLTRWERYNEELARMERLAREGRCLIVYPDAMPVESDTLSTARLTEAYDRGHAQGMRDLPIWREFLFGSADAGPHPDPSAIQAQIREADGDDGYIVIEP
>NZ_CP012069.2|WP_050341256.1|2433863_2434607_-|NAD-dependent-protein-deacylase
MAQTITNAAEAAKQLKERVERAKDVVFFGGAGVSTASGIPDFRSPSGLYNQHFSTSYSPEELLSHHFYLQHPEEFFDFYRKMMCAPEARPNQAHKKLAQLEAEGKLSAVITQNIDGLHQAAGSKHVIELHGSTHRNVCQSCGTVYSQEWVLSTEGVPVCESCGGRVKPDVVLYEEALDERDIVAAVDAISHCDMLIIGGTSLVVYPAAGLVQYFSGDDLVICNMGGTPQDGRADLVCDCDIAGAFDW
>NZ_CP012069.2|WP_050341254.1|2432259_2433711_-|dihydropteroate-synthase
MLREDYSIWCCGRHELSLTRPRVMGILNVTPDSFSDGGENLDPQAAIARALQMLDEGADIIDVGGESTRPGHTPVDPEEEGNRVIPVIRGILAEAPTAIVSIDTRHAAIAKIAVRLGVSIINDVSGFSDPAMARVAAESNCGCIIMHWSKIRGVSTRRSVTLDSPRLRSRRPVQPRTVPTSTRRFTLPEEAPLMREVMGFLGDQARTLMRAGVSHDRICIDPGPGFDKSADEDIVIERATRKLVSMGYPVITALSRKRSVGAVSGIREARERDAASVGMCLSAIEDGSRIVRVHDVAATVQAINGYWSVAKADARQAFVSLGSNVGDRVGNLTHAVKLINKIPLTRVVLVSRAYETEPAYNIATPVANAVAEIRTELHPLVLLDALLGVEDELKRVRDPKLAGHGPRTIDCDLVFVEGEQHAGKRLTLPHPHLGERDYVLVPMEDLLHDPVRFLMHAGVPVYAPEERVGHVVSELGELDWREE
>NZ_CP012069.2|WP_050341252.1|2431378_2432182_+|type-III-pantothenate-kinase
MLLTVDIGNTQTTLGLFNEAGQLLRQWRMASDKTDTADELHERLFGYFLMLGLDLADVRHVAIASVVPVLTREWHYMLGHILEQEDVLTVDATRDCGIKIAMPDPRQVGADRIANAVAARASYGAPVIVVDFGTATNIDVVDGRGAFRGGAIMPGLMLSARALFSQAARLSSVSLVVPAHALGTDTETAVQSGIVIGAAAQAEGLVRRIIDELRAEDPGLSKVPIVGTGGLVREIARATNLFDALDPDLTVRGIYQIWEHRAKKREG
>NZ_CP012069.2|WP_050341250.1|2430684_2431146_-|50S-ribosomal-protein-L31
MKQGIHPKYVECTVRCTCGNTWVTRSTKSEMTIDLCDKCHPFYTGQQKLVDTGGRVQRFSDKFGGAAAAQLKRAQEAKAEKAAKAAEAAAAKKAAKEAKAAEKAKRAAEYAKRSEAKTVEADAAKAPEAPEAGAVEATEATTEVAPVEETSAE
>NZ_CP012069.2|WP_050341248.1|2427755_2430557_+|ABC-transporter-ATP-binding-protein/permease
MLQATDICKGYGERLVLDQVSLSFTDTGLACILGRSGCGKTTLLNILGGLEGDFEGELEIDGRSTRDFLETDWDRYRGQDVGFVFQDASLIGYLSVGDNVRCALDLKNISSPEVEGPVGGDPDAAVAQALEAVGLGDFQDRMPSELSGGETQRVAIARAIVKGPRILLADEPTGSLDLASGEGVMCTLSTIAQDCLVVIVTHDQGLAERYADRIIRLGEGTVESDLTRSGPVSDACGSRAAKADDAGDGGLGGLRHPRHPGHAGMFARLIRQHLGNKLQRALITLLVATIGITGTGLTFAVQSGAHAYMDRIGIASLASNPLVLRQNGTQASLVGVALSALDTLHGNDQQGGDAPSEVTLSHVAQKVAATALAHSKKSDLEQFMRYVDSDRSHIRQNAYDVQRHYDVGINLYDANGRQIVQDGRVTILDNLSLDHIFGKDGERAVSDILPDAASLLREIPYNEETGASPYEVMAGHMPNSYDEAVIICDHDGRVSDYFAYATGLADLEGIREVSVDLMMGKDVRIPGLDDAYSFERLLGLEFDIVPQSDYYYKGDGGWDLANGNARRMKDVLASAPKLRIVGVVRASDKIASVPEVGAIGYSSKLIPWVIDHNSSSEIARQQAGSPNVDVFTGVDFASESRGSNRAIEAERTRNALLSAIDSSLLSQRKLDYLKSLNDEQVMALGDRFKDYFDASGRLYVSQDDVRKVAALPDDQFTAIIESYAPATLNHAYQENMDKLGVADLYEPTSIQIFPSSVEGREQIISELDSYNATLADGEVPVTYASLNQAEVDQVTSVISLVSWALIILMILALGLSAIMIFSVTSVAVIERRREIGILRALGASRRDVVLLFCWENVTVGMCAGILGALFALLLSVPLSLVIQSLTKEAALVSPSPLIIPVSVVVGMTLSLVSGLTPTLRATQTDPAHALRQG
>NZ_CP012069.2|WP_050341263.1|2441791_2443048_+|hypothetical-protein
MGSMMSWPVTRRSAIALGAILATSGGTLLAGCSPKGTAPTGDDASNTDGTSRNGDVPAQGTPADPMTTRIDSTLSALTLEQKINQLFFLEPESIFPASPVVSAGDASRRALTEHPVGGICYFGQNLRGPDQTRTMLSSIRQYSQDAVGLPPFISVDEEGGTVSRIGGKGSFNIPNVGDMRDVGASGDTHQAFEVSQTMAKYLVELGFNLDFAPVADVVNGSSQTMARRSFGTDAQAVAQMVEAAVRGFTEGGILCCAKHFPGIGSAEGDPEVEPISTQKTMEQLQAEELLPFRSAIAAGVPFVMVGHLACPRLTGDDTPASLSRAIQTDILRAQLGFEGIIITDSLKMGAIGDRYNATELGVKALEAGADMLLMTPDFSASYEGVLSAVRDGTLGEERIDDSLRRIIKAKLRLMDASA
>NZ_CP012069.2|WP_157051509.1|2443119_2444217_+|PASTA-domain-containing-protein
MYCTNCGAQLEDGTLFCTQCGCRADAQDDSANETGAATTIASPLSAQPSASTTQVSTATPIQPPLPATQTFAPRREASGGLAAQGFEPYANPVSVSPGKRRRRKSGAAVAGLTIAGLMAVTALSIVILHYFGVLGDPAFLRFLPTRADPAARTQSSGGAEGTSSPRSDLGTKAAVPNVTGMTQEQASSALRSAGFNVGTVTTKEGSGSAKGVVLTQAISGEAERGATIDLVVSAGRRIYTVVPGQMTWPDAEAYCEQHGGTLATVTSQEEWDQVLAAMRADGREVYWIGGRREIDGGNFTWVDGRTFSFTAWATGEPNYQTNKVGPENYLAVYKVNGQYGWYDDPYDLDPFYKASVMAFVMQTVE
>NZ_CP012069.2|WP_083443964.1|2444295_2445690_+|PrsW-family-intramembrane-metalloprotease
MFCMNCGAQIASGTSSCPRCGVPLTPQPRSGPRCPRCGGELPPGQAFCPTCGFMAAGASMGGPTPQAQWTWQGQGTWQGQDVPQAQSVLQGPGTPQAQQSALSWAAQGIADQVNKLVGGTSRVELRFRDFFDAVPRHHARGEAEDLFMCGTRSTTPSITQAVTEWPHPWLYSRVLLVLGIVFLGLVILSYAMSDPSSLPGLLFIGSMAVPFATVIFFFETNAPRDISIVEVVAIFFVGGVASILMSYPIDALFPGSGVGDVIPSLLTGLIEELAKISIVIVFLMRRNKRVYILGGILIGAAVGAGFDMFESAGYAFVNFLETFISSTYDELASAYMAGVGDAIQITLLRGVTTIGGHVAWAAIEGGAIALFRQDERLDFSYLAQPQLLGIFGITIVLHGVWDMDIPILDNLELFYMTPKTALLIAVAWIVLVVLMQQGLQQVNEEAMRHRNVAAPVGAPAGFGL
>NZ_CP012069.2|WP_083443965.1|2446023_2447217_+|NINE-protein
MSFCSHCGGSVPDSARFCPKCGSPAHAVQPAAATMAPTSTSDTMGVVSASMTTVTTATAPVVAEPIPTPYRELESTVQSTPPMAEQVPEEETGTDSAIGEGVDTQDITVNDVPESTEGDEGAKAQPSTDPEELVDTRPSELDEPTPNEPTPTNSEVTGESETKQEDEKPLFSEAIDHGEHPEGTDSSPSPQPQTETLETQLHPQEPSQAPYSTGQKSHLASDVTQWNPQTQAQASYPQTQAQAQASYSQQAQPQLPYPQQAQQQASYSQQAQPQLPYPQQQASYSQQAQQQAPYTQPYPQQQASYTQVQVFTNSQPTGGGPTKSKVAAGLLAIFLGTLGIHKFYLGRTGEGILILVLDILLGWTFIVPGIIEFVCFIEALIYFTKSDEEFQRDCVRG
>NZ_CP012069.2|WP_050341271.1|2447352_2448471_-|serine-hydrolase
MVKPNILRTLLENHRRLRLCAVIMAAIAILMVSGAIIWTHGSPRPVTGTTGQNSSDDGGQDVPASSLPAVMDPRAEAPAEATNPEEGARVSDAPPEAVRSDEPAVHDNPTPADSGRDNAVRAAVEPLVSPYGDEVAVVYTPVDAPDGGFAINGDERMRSASMIKTLIMATLLQHEADGSISLGDSYTIRESDIVGGTGSVQSMGAGTRLSLSRLAELMISQSDNVATNVLIDRLGMGTVNDEGARLGLGQTVLARKMMDTAAAAAGRENYTSASDQARILRLVASGDLASPEASQAALAWLKEQEDSEGIAQGVPSGTVVAHKTGTLDSVRHDGAIVYGKRPYVLVIMTHGMSDGAANSLMARVSRTVWDAA
>NZ_CP012069.2|WP_050341273.1|2449095_2449902_+|Rpn-family-recombination-promoting-nuclease/putative-transposase
MAQARRDMGELRPIDDLMFRVMARDKAFCGELLRVLLQDPKLEVVECEPQSAVTNPHGRSVVLDALCELSGGRFVDVEVQRTDRDDLQRRARYHASLVTADRTRPGTPFKDVPDVCVAFVCEFDPLGEGRSLYHVDRVVRESGRTLENGLSEVYVNALARDGTDVSALMRVFTEAEAYDEGRFPETSRVKRRLRETEEGRKDMGSVIEEIRAECIAEGKAEGIAEGEVRGTLKTLVRLVRDGLVSVQDAAASAGVDADEIKRTLAAEG
>NZ_CP012069.2|WP_157051510.1|2450005_2450308_+|hypothetical-protein
MRVLTEAEAYDEGRFPETSRVKRRLRETEEGRKDMGSVIEEIRAECIAEGIETGRAEGKAEGRLEALGRLVRDGLVSVQDAAASAGVDADEIRRTLAAEG
>NZ_CP012069.2|WP_050341278.1|2450458_2450788_-|glutathione-S-transferase-N-terminal-domain-containing-protein
MAKKDLQLYVKNGCPFCRKVEGFMKRSGIELALHNIDESDADRSYLVEHGGKRQVPCLFIDGKAMYESNDIIDYLGREFGVSANATDDAAAPAKASGGACSLDGSGCSF
>NZ_CP012069.2|WP_050341279.1|2450853_2451237_-|fluoride-efflux-transporter-CrcB
MLGQALAVGCGGFLGSIVRWGIGEVLGRAIPALPGGTLVANVVAGFVIGLVTGLDLARPLPGHAKLFLATGICGGLSTFSTFSNETFQLLSMGHVWTAALNIAANVISSLVAVAVGLAIARMLAAAA
>NZ_CP012069.2|WP_172674529.1|2451283_2453053_-|aspartate--tRNA-ligase
MHMHSMHTHSCGELRREDIGREVTLTGWVWHRRDHGGLIFVDLRDRAGLTQVAFDPEHSGGVAFHRAETIRSEWPIKVSGVVRERPEGQDNEKLATGEVEVLVSDIEVLNTAKTPVFQIEDHVEVAEDVRLRYRYLDLRRPQMMSALRLRSDFTFAIRQAFHRRAFMEVETPSLFKSTPEGARDFLVPSRTQPGHFYALPQSPQLLKQLLMVGGVERYYQIARCFRDEDLRSDRQPEFTQVDVEMSFVTQDDVMGVLEEALADAFGEVGVSMELPLRRVSYWDTMDTYGTDKPDTRYGMRLHDVTHIFESSAFKLFASAAADPKTYVKAINAKGAGSWPRAQLDKLAGVAASFGAKGLAYIAFRGDGSVTSPIVKFFSDAEMAALRLEMDVEPGDLVMFAVESRRVADEVLGGMRSHMADALGIPREGHDFLWVVDFPLFHWDEDRKAYAAEHQPFTQPIEADIERLDSDPLSVGSHTYDFVMDGFEAGGGGVRIHDADLQLRILKKLGFSEEQATEQFGFLMDALRYGAPPMGGFALGLDRVCMLLAGSDSIREVMAFPKTSSGSDLMSDAPAEVSGRQLREVSLRLL

Crispr_ID: NZ_CP012069_27

• CRISPR_ID: NZ_CP012069_27
• CRISPR_location: 2445793-2445901
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_27

Consensus_repeat	Method
GTTGTGCCCTCCTGTCGATGACAAAGCCAAGCCATC	CRISPRCasFinder

spacers of NZ_CP012069_27

>27.1|2445829|37|NZ_CP012069|CRISPRCasFinder
TCAAGTGGCATTGAGTAGTACCTAACGTCCGTGTATA

CRISPR arrays and Neighbor proteins around NZ_CP012069_27

CRISPR arrays

The CRISPR arrays of NZ_CP012069_27

>merge|NZ_CP012069|27|2445793-2445901|CRISPRCasFinder
GTTGTGCCCTCCTGTCGATGACAAAGCCAAGCCATCTCAAGTGGCATTGAGTAGTACCTAACGTCCGTGTATAGTTGTGCCCTCCTGTCGATGACAAAGCTAAGCCATC

>NZ_CP012069|27|24|2445793-2445901|CRISPRCasFinder
GTTGTGCCCTCCTGTCGATGACAAAGCCAAGCCATC	TCAAGTGGCATTGAGTAGTACCTAACGTCCGTGTATA
GTTGTGCCCTCCTGTCGATGACAAAGCTAAGCCATC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_157051510.1|2450005_2450308_+|hypothetical-protein	unknown	unknown	gnl|CDD|273806
NZ_CP012069.2|WP_050341256.1|2433863_2434607_-|NAD-dependent-protein-deacylase	unknown	unknown	gnl|CDD|234777
NZ_CP012069.2|WP_050341278.1|2450458_2450788_-|glutathione-S-transferase-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|366113
NZ_CP012069.2|WP_050341257.1|2434763_2435750_+|patatin-family-protein	unknown	unknown	gnl|CDD|132847
NZ_CP012069.2|WP_172674490.1|2438563_2439826_-|NINE-protein	unknown	unknown	gnl|CDD|377473
NZ_CP012069.2|WP_050341287.1|2456856_2458536_-|alpha,alpha-phosphotrehalase	unknown	unknown	gnl|CDD|274115
NZ_CP012069.2|WP_050341263.1|2441791_2443048_+|hypothetical-protein	unknown	unknown	gnl|CDD|366376
NZ_CP012069.2|WP_050341271.1|2447352_2448471_-|serine-hydrolase	unknown	unknown	gnl|CDD|379138
NZ_CP012069.2|WP_050341285.1|2455221_2456535_-|histidine--tRNA-ligase	unknown	unknown	gnl|CDD|234586
NZ_CP012069.2|WP_050341259.1|2436872_2437691_-|phosphatase	unknown	unknown	gnl|CDD|213992
NZ_CP012069.2|WP_050341279.1|2450853_2451237_-|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl|CDD|223317
NZ_CP012069.2|WP_050341273.1|2449095_2449902_+|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl|CDD|273806
NZ_CP012069.2|WP_172674491.1|2440230_2441079_-|SPOR-domain-containing-protein	unknown	unknown	gnl|CDD|379084
NZ_CP012069.2|WP_083443964.1|2444295_2445690_+|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|225217
NZ_CP012069.2|WP_050341254.1|2432259_2433711_-|dihydropteroate-synthase	unknown	unknown	gnl|CDD|273657
NZ_CP012069.2|WP_172674492.1|2453370_2454720_-|CapA-family-protein	unknown	unknown	gnl|CDD|378215
NZ_CP012069.2|WP_157051509.1|2443119_2444217_+|PASTA-domain-containing-protein	unknown	unknown	gnl|CDD|153057
NZ_CP012069.2|WP_083443961.1|2435819_2436722_+|exodeoxyribonuclease-III	unknown	unknown	gnl|CDD|197321
NZ_CP012069.2|WP_172674529.1|2451283_2453053_-|aspartate--tRNA-ligase	unknown	unknown	gnl|CDD|234775
NZ_CP012069.2|WP_083443965.1|2446023_2447217_+|NINE-protein	unknown	unknown	gnl|CDD|377473

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_157051510.1|2450005_2450308_+|hypothetical-protein	gnl|CDD|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	0.00161021
NZ_CP012069.2|WP_050341256.1|2433863_2434607_-|NAD-dependent-protein-deacylase	gnl|CDD|234777	PRK00481, PRK00481, NAD-dependent deacetylase; Provisional.	7.82129e-106
NZ_CP012069.2|WP_050341278.1|2450458_2450788_-|glutathione-S-transferase-N-terminal-domain-containing-protein	gnl|CDD|366113	pfam00462, Glutaredoxin, Glutaredoxin.	1.77492e-17
NZ_CP012069.2|WP_050341257.1|2434763_2435750_+|patatin-family-protein	gnl|CDD|132847	cd07208, Pat_hypo_Ecoli_yjju_like, Hypothetical patatin similar to yjju protein of Escherichia coli. Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	4.0912e-58
NZ_CP012069.2|WP_172674490.1|2438563_2439826_-|NINE-protein	gnl|CDD|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	1.16049e-16
NZ_CP012069.2|WP_050341287.1|2456856_2458536_-|alpha,alpha-phosphotrehalase	gnl|CDD|274115	TIGR02403, Trehalose-6-phosphate_hydrolase, alpha,alpha-phosphotrehalase. Trehalose is a glucose disaccharide that serves in many biological systems as a compatible solute for protection against hyperosmotic and thermal stress. This family describes trehalose-6-phosphate hydrolase, product of the treC (or treA) gene, which is often found together with a trehalose uptake transporter and a trehalose operon repressor.	0
NZ_CP012069.2|WP_050341263.1|2441791_2443048_+|hypothetical-protein	gnl|CDD|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	4.52728e-74
NZ_CP012069.2|WP_050341271.1|2447352_2448471_-|serine-hydrolase	gnl|CDD|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	6.0945e-64
NZ_CP012069.2|WP_050341285.1|2455221_2456535_-|histidine--tRNA-ligase	gnl|CDD|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	2.62945e-175
NZ_CP012069.2|WP_050341259.1|2436872_2437691_-|phosphatase	gnl|CDD|213992	cd07437, PHP_HisPPase_Ycdx_like, Polymerase and Histidinol Phosphatase domain of Ycdx like. PHP Ycdx-like is a stand alone PHP domain similar to Ycdx E. coli protein with an unknown physiological role. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. It has also been shown that the PHP domain functions in DNA repair. The PHP structures have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel. YcdX may be involved in swarming.	3.86592e-103
NZ_CP012069.2|WP_050341279.1|2450853_2451237_-|fluoride-efflux-transporter-CrcB	gnl|CDD|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	3.83618e-28
NZ_CP012069.2|WP_050341273.1|2449095_2449902_+|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl|CDD|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	6.99099e-15
NZ_CP012069.2|WP_172674491.1|2440230_2441079_-|SPOR-domain-containing-protein	gnl|CDD|379084	pfam13240, zinc_ribbon_2, zinc-ribbon domain. This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.	1.07455e-05
NZ_CP012069.2|WP_083443964.1|2444295_2445690_+|PrsW-family-intramembrane-metalloprotease	gnl|CDD|225217	COG2339, prsW, Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones].	9.71626e-25
NZ_CP012069.2|WP_050341254.1|2432259_2433711_-|dihydropteroate-synthase	gnl|CDD|273657	TIGR01496, Dihydropteroate_synthase, dihydropteroate synthase. This model represents dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis. The gene is usually designated folP (folic acid biosynthsis) or sul (sulfanilamide resistance). This model represents one branch of the family of pterin-binding enzymes (pfam00809) and of a cluster of dihydropteroate synthase and related enzymes (COG0294). Other members of pfam00809 and COG0294 are represented by model TIGR00284. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid].	6.17808e-92
NZ_CP012069.2|WP_172674492.1|2453370_2454720_-|CapA-family-protein	gnl|CDD|378215	pfam09587, PGA_cap, Bacterial capsule synthesis protein PGA_cap. This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.	1.24245e-60
NZ_CP012069.2|WP_157051509.1|2443119_2444217_+|PASTA-domain-containing-protein	gnl|CDD|153057	cd00037, CLECT, C-type lectin (CTL)/C-type lectin-like (CTLD) domain. CLECT: C-type lectin (CTL)/C-type lectin-like (CTLD) domain; protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. This group is chiefly comprised of eukaryotic CTLDs, but contains some, as yet functionally uncharacterized, bacterial CTLDs. Many CTLDs are calcium-dependent carbohydrate binding modules; other CTLDs bind protein ligands, lipids, and inorganic surfaces, including CaCO3 and ice. Animal C-type lectins are involved in such functions as extracellular matrix organization, endocytosis, complement activation, pathogen recognition, and cell-cell interactions. For example: mannose-binding lectin and lung surfactant proteins A and D bind carbohydrates on surfaces (e.g. pathogens, allergens, necrotic, and apoptotic cells) and mediate functions associated with killing and phagocytosis; P (platlet)-, E (endothelial)-, and L (leukocyte)- selectins (sels) mediate the initial attachment, tethering, and rolling of lymphocytes on inflamed vascular walls enabling subsequent lymphocyte adhesion and transmigration. CTLDs may bind a variety of carbohydrate ligands including mannose, N-acetylglucosamine, galactose, N-acetylgalactosamine, and fucose. Several CTLDs bind to protein ligands, and only some of these binding interactions are Ca2+-dependent; including the CTLDs of Coagulation Factors IX/X (IX/X) and Von Willebrand Factor (VWF) binding proteins, and natural killer cell receptors. C-type lectins, such as lithostathine, and some type II antifreeze glycoproteins function in a Ca2+-independent manner to bind inorganic surfaces. Many proteins in this group contain a single CTLD; these CTLDs associate with each other through several different surfaces to form dimers, trimers, or tetramers, from which ligand-binding sites project in different orientations. Various vertebrate type 1 transmembrane proteins including macrophage mannose receptor, endo180, phospholipase A2 receptor, and dendritic and epithelial cell receptor (DEC205) have extracellular domains containing 8 or more CTLDs; these CTLDs remain in the parent model. In some members (IX/X and VWF binding proteins), a loop extends to the adjoining domain to form a loop-swapped dimer. A similar conformation is seen in the macrophage mannose receptor CRD4's putative non-sugar bound form of the domain in the acid environment of the endosome. Lineage specific expansions of CTLDs have occurred in several animal lineages including Drosophila melanogaster and Caenorhabditis elegans; these CTLDs also remain in the parent model.	3.07677e-28
NZ_CP012069.2|WP_083443961.1|2435819_2436722_+|exodeoxyribonuclease-III	gnl|CDD|197321	cd09087, Ape1-like_AP-endo, Human Ape1-like subfamily of the ExoIII family apurinic/apyrimidinic (AP) endonucleases. This subfamily includes human Ape1 (also known as Apex, Hap1, or Ref-1) and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Ape1 and Ape2 in humans. Ape1 is found in this subfamily, it exhibits strong AP-endonuclease activity but shows weak 3'-5' exonuclease and 3'-phosphodiesterase activities. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes exonuclease III (ExoIII) and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	1.3422e-139
NZ_CP012069.2|WP_172674529.1|2451283_2453053_-|aspartate--tRNA-ligase	gnl|CDD|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP012069.2|WP_083443965.1|2446023_2447217_+|NINE-protein	gnl|CDD|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	1.18776e-18

Protein sequences

>NZ_CP012069.2|WP_083443964.1|2444295_2445690_+|PrsW-family-intramembrane-metalloprotease
MFCMNCGAQIASGTSSCPRCGVPLTPQPRSGPRCPRCGGELPPGQAFCPTCGFMAAGASMGGPTPQAQWTWQGQGTWQGQDVPQAQSVLQGPGTPQAQQSALSWAAQGIADQVNKLVGGTSRVELRFRDFFDAVPRHHARGEAEDLFMCGTRSTTPSITQAVTEWPHPWLYSRVLLVLGIVFLGLVILSYAMSDPSSLPGLLFIGSMAVPFATVIFFFETNAPRDISIVEVVAIFFVGGVASILMSYPIDALFPGSGVGDVIPSLLTGLIEELAKISIVIVFLMRRNKRVYILGGILIGAAVGAGFDMFESAGYAFVNFLETFISSTYDELASAYMAGVGDAIQITLLRGVTTIGGHVAWAAIEGGAIALFRQDERLDFSYLAQPQLLGIFGITIVLHGVWDMDIPILDNLELFYMTPKTALLIAVAWIVLVVLMQQGLQQVNEEAMRHRNVAAPVGAPAGFGL
>NZ_CP012069.2|WP_157051509.1|2443119_2444217_+|PASTA-domain-containing-protein
MYCTNCGAQLEDGTLFCTQCGCRADAQDDSANETGAATTIASPLSAQPSASTTQVSTATPIQPPLPATQTFAPRREASGGLAAQGFEPYANPVSVSPGKRRRRKSGAAVAGLTIAGLMAVTALSIVILHYFGVLGDPAFLRFLPTRADPAARTQSSGGAEGTSSPRSDLGTKAAVPNVTGMTQEQASSALRSAGFNVGTVTTKEGSGSAKGVVLTQAISGEAERGATIDLVVSAGRRIYTVVPGQMTWPDAEAYCEQHGGTLATVTSQEEWDQVLAAMRADGREVYWIGGRREIDGGNFTWVDGRTFSFTAWATGEPNYQTNKVGPENYLAVYKVNGQYGWYDDPYDLDPFYKASVMAFVMQTVE
>NZ_CP012069.2|WP_050341263.1|2441791_2443048_+|hypothetical-protein
MGSMMSWPVTRRSAIALGAILATSGGTLLAGCSPKGTAPTGDDASNTDGTSRNGDVPAQGTPADPMTTRIDSTLSALTLEQKINQLFFLEPESIFPASPVVSAGDASRRALTEHPVGGICYFGQNLRGPDQTRTMLSSIRQYSQDAVGLPPFISVDEEGGTVSRIGGKGSFNIPNVGDMRDVGASGDTHQAFEVSQTMAKYLVELGFNLDFAPVADVVNGSSQTMARRSFGTDAQAVAQMVEAAVRGFTEGGILCCAKHFPGIGSAEGDPEVEPISTQKTMEQLQAEELLPFRSAIAAGVPFVMVGHLACPRLTGDDTPASLSRAIQTDILRAQLGFEGIIITDSLKMGAIGDRYNATELGVKALEAGADMLLMTPDFSASYEGVLSAVRDGTLGEERIDDSLRRIIKAKLRLMDASA
>NZ_CP012069.2|WP_172674491.1|2440230_2441079_-|SPOR-domain-containing-protein
MATGEFCTNCGAQLDRDAQFCVSCGQSRQDDEGQRAAVANATVVQEPVQASVDPTASTDPSVPCGAVDHAFPIQTASPVSVRTGAERAEPDRTGRGGRGPVIAATVAIVFSVLSISLSLLYLFVWPAATNRIASVGWQQEQSSDADLTSSSPSENAGSKSSGSASDQGAAASGAPKNSPTEGERDPGYRTGYHEPFWGVWTFASKSASEAMERATSMTAKGFDSTVELTTDWSNLNDEEWYVVTTGMWRDREEAESMASSLRLAGYSDAYAKYSGEYVGDKR
>NZ_CP012069.2|WP_172674490.1|2438563_2439826_-|NINE-protein
MFCTRCGNSLPANARFCSRCGNPVFGVQPVVPVAPTTALATQSTTSYHPRQSTISDTYPTVPVAASDVAQVATTLAQVDVSATATVPVAEVSAAVPSLVEGAVSETVGERAARDKPVSASGPAPTYIPVAKDREAMPTVTDDSFPAEGAALPAAPREPPTMKTVVANDPDQTVTGVVYTETRTAGEVERGIVEEASKGEEETAVSQSDGLGAKNALEDANTNKETGSYTALAKAIPEDRARGARRLTDDELARLSIEVTELRKSMKKIQQLLLSSGAITPAQYCRAMYGSPSPHGSPLSPSAADQSFPQVSVSAQASYDQTQVLTVPSTQTASVRRTDSEKGRLAAGLLAIFLGGLGVHKFYLGYTGAGVAMLLISIFGAVILIGPILMGLCGLIEGIIYLTKSDEDFQRTYVWGDKPWF
>NZ_CP012069.2|WP_050341259.1|2436872_2437691_-|phosphatase
MLHIRCDTHTHTIYSRHAYSTVEENVRAAAELGIGLLGSTDHYSSMLFPEVEDTRRAHVHDLRDHQYFINYHCWPREWCGVRLLHGCEADIVDLEGHLFGWDVAVDREINGTLLPESTTLKERVFKDCDYVIASVHNDDFTKGATLAKTTEMYLRALEDPKVLILGHLGRSGVPFDVDAVLMSARERGKMVEINEATLANHTEAAASCRAIASRAAELGCMVSTGSDAHISYDVGRLGRVRGLLEDLHFPQELIATTDADSFLEALRRAVVP
>NZ_CP012069.2|WP_083443961.1|2435819_2436722_+|exodeoxyribonuclease-III
MRPGVAARKSGAPRPSLSTRHNFPAEGDIVSDTPSTPTTDSDTDASELTLVSWNVNGLRAVLKKEPSFAEVFNSCSADVFAIQETKLQEGQVDLDIPGYVQTWSFAKRKGYSGTAVFSREEPLQVVRQIGSPVAEDEGRVCALEFTGYWFVNVYTPNSKNGLARLDERMLWDERYRSFLAGLAKEKPVVSCGDFNVAHEEIDLKNPDTNHQNAGFSDQEREGFTRLLDAGFTDSFRKLYPDRADAYSWWSYRMRARERNVGWRIDYFLVSDDAAGRITGASILDDVYGSDHCPVELRIRL
>NZ_CP012069.2|WP_050341257.1|2434763_2435750_+|patatin-family-protein
MTALDTNISDCALVFEGGGYRGAYTAGFARVLLEQQFHFGFVCGLSAGASHTVDYTSRDLHRTRAAFLARKPAGVQIGGIRSIVQGTGLFNADYLYAGCVEDGFLPFDWETFCANPAQIRIQTFERDTGRTVTFGKEDMPDVMTMINLVRASSTLPGAMKPLPVNGRVLLDGGLGKGAGIPVRLAEEAGYRRFFFVATRPKGYRKQPPTKRELRMQNLVSRDYPYLRNAMLTRWERYNEELARMERLAREGRCLIVYPDAMPVESDTLSTARLTEAYDRGHAQGMRDLPIWREFLFGSADAGPHPDPSAIQAQIREADGDDGYIVIEP
>NZ_CP012069.2|WP_050341256.1|2433863_2434607_-|NAD-dependent-protein-deacylase
MAQTITNAAEAAKQLKERVERAKDVVFFGGAGVSTASGIPDFRSPSGLYNQHFSTSYSPEELLSHHFYLQHPEEFFDFYRKMMCAPEARPNQAHKKLAQLEAEGKLSAVITQNIDGLHQAAGSKHVIELHGSTHRNVCQSCGTVYSQEWVLSTEGVPVCESCGGRVKPDVVLYEEALDERDIVAAVDAISHCDMLIIGGTSLVVYPAAGLVQYFSGDDLVICNMGGTPQDGRADLVCDCDIAGAFDW
>NZ_CP012069.2|WP_050341254.1|2432259_2433711_-|dihydropteroate-synthase
MLREDYSIWCCGRHELSLTRPRVMGILNVTPDSFSDGGENLDPQAAIARALQMLDEGADIIDVGGESTRPGHTPVDPEEEGNRVIPVIRGILAEAPTAIVSIDTRHAAIAKIAVRLGVSIINDVSGFSDPAMARVAAESNCGCIIMHWSKIRGVSTRRSVTLDSPRLRSRRPVQPRTVPTSTRRFTLPEEAPLMREVMGFLGDQARTLMRAGVSHDRICIDPGPGFDKSADEDIVIERATRKLVSMGYPVITALSRKRSVGAVSGIREARERDAASVGMCLSAIEDGSRIVRVHDVAATVQAINGYWSVAKADARQAFVSLGSNVGDRVGNLTHAVKLINKIPLTRVVLVSRAYETEPAYNIATPVANAVAEIRTELHPLVLLDALLGVEDELKRVRDPKLAGHGPRTIDCDLVFVEGEQHAGKRLTLPHPHLGERDYVLVPMEDLLHDPVRFLMHAGVPVYAPEERVGHVVSELGELDWREE
>NZ_CP012069.2|WP_083443965.1|2446023_2447217_+|NINE-protein
MSFCSHCGGSVPDSARFCPKCGSPAHAVQPAAATMAPTSTSDTMGVVSASMTTVTTATAPVVAEPIPTPYRELESTVQSTPPMAEQVPEEETGTDSAIGEGVDTQDITVNDVPESTEGDEGAKAQPSTDPEELVDTRPSELDEPTPNEPTPTNSEVTGESETKQEDEKPLFSEAIDHGEHPEGTDSSPSPQPQTETLETQLHPQEPSQAPYSTGQKSHLASDVTQWNPQTQAQASYPQTQAQAQASYSQQAQPQLPYPQQAQQQASYSQQAQPQLPYPQQQASYSQQAQQQAPYTQPYPQQQASYTQVQVFTNSQPTGGGPTKSKVAAGLLAIFLGTLGIHKFYLGRTGEGILILVLDILLGWTFIVPGIIEFVCFIEALIYFTKSDEEFQRDCVRG
>NZ_CP012069.2|WP_050341271.1|2447352_2448471_-|serine-hydrolase
MVKPNILRTLLENHRRLRLCAVIMAAIAILMVSGAIIWTHGSPRPVTGTTGQNSSDDGGQDVPASSLPAVMDPRAEAPAEATNPEEGARVSDAPPEAVRSDEPAVHDNPTPADSGRDNAVRAAVEPLVSPYGDEVAVVYTPVDAPDGGFAINGDERMRSASMIKTLIMATLLQHEADGSISLGDSYTIRESDIVGGTGSVQSMGAGTRLSLSRLAELMISQSDNVATNVLIDRLGMGTVNDEGARLGLGQTVLARKMMDTAAAAAGRENYTSASDQARILRLVASGDLASPEASQAALAWLKEQEDSEGIAQGVPSGTVVAHKTGTLDSVRHDGAIVYGKRPYVLVIMTHGMSDGAANSLMARVSRTVWDAA
>NZ_CP012069.2|WP_050341273.1|2449095_2449902_+|Rpn-family-recombination-promoting-nuclease/putative-transposase
MAQARRDMGELRPIDDLMFRVMARDKAFCGELLRVLLQDPKLEVVECEPQSAVTNPHGRSVVLDALCELSGGRFVDVEVQRTDRDDLQRRARYHASLVTADRTRPGTPFKDVPDVCVAFVCEFDPLGEGRSLYHVDRVVRESGRTLENGLSEVYVNALARDGTDVSALMRVFTEAEAYDEGRFPETSRVKRRLRETEEGRKDMGSVIEEIRAECIAEGKAEGIAEGEVRGTLKTLVRLVRDGLVSVQDAAASAGVDADEIKRTLAAEG
>NZ_CP012069.2|WP_157051510.1|2450005_2450308_+|hypothetical-protein
MRVLTEAEAYDEGRFPETSRVKRRLRETEEGRKDMGSVIEEIRAECIAEGIETGRAEGKAEGRLEALGRLVRDGLVSVQDAAASAGVDADEIRRTLAAEG
>NZ_CP012069.2|WP_050341278.1|2450458_2450788_-|glutathione-S-transferase-N-terminal-domain-containing-protein
MAKKDLQLYVKNGCPFCRKVEGFMKRSGIELALHNIDESDADRSYLVEHGGKRQVPCLFIDGKAMYESNDIIDYLGREFGVSANATDDAAAPAKASGGACSLDGSGCSF
>NZ_CP012069.2|WP_050341279.1|2450853_2451237_-|fluoride-efflux-transporter-CrcB
MLGQALAVGCGGFLGSIVRWGIGEVLGRAIPALPGGTLVANVVAGFVIGLVTGLDLARPLPGHAKLFLATGICGGLSTFSTFSNETFQLLSMGHVWTAALNIAANVISSLVAVAVGLAIARMLAAAA
>NZ_CP012069.2|WP_172674529.1|2451283_2453053_-|aspartate--tRNA-ligase
MHMHSMHTHSCGELRREDIGREVTLTGWVWHRRDHGGLIFVDLRDRAGLTQVAFDPEHSGGVAFHRAETIRSEWPIKVSGVVRERPEGQDNEKLATGEVEVLVSDIEVLNTAKTPVFQIEDHVEVAEDVRLRYRYLDLRRPQMMSALRLRSDFTFAIRQAFHRRAFMEVETPSLFKSTPEGARDFLVPSRTQPGHFYALPQSPQLLKQLLMVGGVERYYQIARCFRDEDLRSDRQPEFTQVDVEMSFVTQDDVMGVLEEALADAFGEVGVSMELPLRRVSYWDTMDTYGTDKPDTRYGMRLHDVTHIFESSAFKLFASAAADPKTYVKAINAKGAGSWPRAQLDKLAGVAASFGAKGLAYIAFRGDGSVTSPIVKFFSDAEMAALRLEMDVEPGDLVMFAVESRRVADEVLGGMRSHMADALGIPREGHDFLWVVDFPLFHWDEDRKAYAAEHQPFTQPIEADIERLDSDPLSVGSHTYDFVMDGFEAGGGGVRIHDADLQLRILKKLGFSEEQATEQFGFLMDALRYGAPPMGGFALGLDRVCMLLAGSDSIREVMAFPKTSSGSDLMSDAPAEVSGRQLREVSLRLL
>NZ_CP012069.2|WP_172674492.1|2453370_2454720_-|CapA-family-protein
MSVVVTLVVTVLVVIGLAGLTKPLSNGFNSIQSWFAQMLGDPSASPSDPLVQGTSGRGAVAIREKTPGQGSVTIDLVMVGDVLQHTGVYRSGKQADGSYNFDHVFSHIVPALEGVDVKVLNQETPLGGAELGYTGYPSFNGPQEMGDAEVTAGFNVILKATNHAMDRSYAGIHNELEFWHEKHPDVAVLGERDVQSTDPGSLDNVYIYKKDGFKVALLNYTYGLNGIPDPQGAVSLLDEGRIRANVMSARLRGADIVVAFPHWGTEYVSAPTAEQHSWAEVFRSAGVDVIIGGHPHVIGPVEMLGDEGDKQTLCFWSVGNFICTQSDNSSLIGGMAKLRLVKDSSGHASVWSYHFLPLVIDRGKGMTTYLLRDWTDALASQSSTPSLTPAWAQGFCSSVLGDAYDTETSELSGTMSPEAISSGDFDAADGQRATSAILHFGGTALGPAA
>NZ_CP012069.2|WP_050341285.1|2455221_2456535_-|histidine--tRNA-ligase
MAQRIQGTEDLYGGYMRGWQHIQDTARELFGTYGFDMIETPAIEQVDTFVHGIGESTDVVRKEMFRVFSGALMERLIGAGGEGGLKAKQRMALRPEGTAGVVRAAVEDKLVSQGAAPVKLWYAEAMFRGERPQKGRLRQFHQVGIEWMGAPDPAADAECVIVLMEYFRLLGFDPARLRLRINSMGDATCRPAYREKVRDFIIAHAHELCADCRERADVNPLRAFDCKVDHDREIMAHAPLVTDHLCDTCAAHYAQVKCYLDEAGVAYVEDPTLVRGLDYYTRTVFEVDALDSGVGAIGGGGRYDDLVELEGGRPTPGIGFAVGFERISLALAACGGSLETKPPACVYVACAAPEQRDAVFSTSLALRRAGVRTEADYQGRSLKSQFKQADRLGARLCVVLGADEVASGTATLRDMQTHEQVRLPLAELVATVSQRIS
>NZ_CP012069.2|WP_050341287.1|2456856_2458536_-|alpha,alpha-phosphotrehalase
MDRAEQFGDKVVYQIYIRSFKDSNDDGIGDLRGITYCLDYLKELGVDCVWITPFFVSPQNDNGYDVADYRNIDPVFGSMEDFDELVSEARERDIAIMLDMVFNHTSTEHEWFQKALKGDPTYLDYYKFVDAAEGATEENPGEPPTNWVSKFGGSAWQYVPSLNKWYLHLFDKSQADLNWDNPRVRNELADVIRFWKAKGVSAFRFDVVNLISKPSELRSDDEGDGRRFYTDGPHVHEYLQELVREAGIDDLMTVGEMSSTSIDDCVRYSKPDCHELAMTFSFHHLKVDYLNGDKWALAEPDISALRRLFAEWQERMSADGGWNALFWSNHDQPRPNSRFGDVSSRELWRRSSELLGLCTHLMRGTPYVYQGEELGMTNPGFASIDDYRDVETKNYYKILQDGGMSADEAFHVVSERSRDNSRTPVQWDGSDHAGFTSGTPWIGVPDNHLWLNAAVEEGDPDSVWIFYRDLISLRKENAVIQRGTVRFLESPSDKVIAYERTLGQDRIVVACNFSGEDVTALSADTVAGSSTLIANCGDPTFDEKGALSLRPYEAVALAW

Crispr_ID: NZ_CP012069_28

• CRISPR_ID: NZ_CP012069_28
• CRISPR_location: 2529159-2529244
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_28

Consensus_repeat	Method
CCCCGCAGCCTGGCGGGGGGTTGC	CRISPRCasFinder

spacers of NZ_CP012069_28

>28.1|2529183|38|NZ_CP012069|CRISPRCasFinder
TCGAGCACGTTTGCCCAGTTGGGCCACTCTCCATAGTG

CRISPR arrays and Neighbor proteins around NZ_CP012069_28

CRISPR arrays

The CRISPR arrays of NZ_CP012069_28

>merge|NZ_CP012069|28|2529159-2529244|CRISPRCasFinder
CCCCGCAGCCTGGCGGGGGGTTGCTCGAGCACGTTTGCCCAGTTGGGCCACTCTCCATAGTGCCCCGCAGGCTGGCGGGGGGTTGC

>NZ_CP012069|28|25|2529159-2529244|CRISPRCasFinder
CCCCGCAGCCTGGCGGGGGGTTGC	TCGAGCACGTTTGCCCAGTTGGGCCACTCTCCATAGTG
CCCCGCAGGCTGGCGGGGGGTTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050341382.1|2520951_2521140_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341400.1|2536213_2536420_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341378.1|2518473_2519625_-|ATP-binding-protein	unknown	unknown	gnl|CDD|379062
NZ_CP012069.2|WP_050341380.1|2519751_2520711_-|zinc-binding-dehydrogenase	unknown	unknown	gnl|CDD|176205
NZ_CP012069.2|WP_050341384.1|2521136_2522963_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_172674496.1|2529847_2532418_+|DUF2339-domain-containing-protein	unknown	unknown	gnl|CDD|378390
NZ_CP012069.2|WP_050341387.1|2526306_2527059_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl|CDD|223692
NZ_CP012069.2|WP_050341386.1|2522956_2526310_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_157051515.1|2538435_2538609_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341402.1|2536717_2537554_-|ABC-transporter-permease	unknown	unknown	unknown
NZ_CP012069.2|WP_050341391.1|2528054_2528816_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NZ_CP012069.2|WP_050341404.1|2537550_2538288_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213235
NZ_CP012069.2|WP_050341411.1|2539275_2540190_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl|CDD|378065
NZ_CP012069.2|WP_050341398.1|2534999_2536106_-|Fic-family-protein	unknown	unknown	gnl|CDD|225718
NZ_CP012069.2|WP_083443973.1|2533865_2534588_-|HD-domain-containing-protein	unknown	unknown	gnl|CDD|224336
NZ_CP012069.2|WP_050341389.1|2527059_2527677_-|MptD-family-putative-ECF-transporter-S-component	unknown	unknown	gnl|CDD|370580
NZ_CP012069.2|WP_083443971.1|2517994_2518510_-|DUF4143-domain-containing-protein	unknown	unknown	gnl|CDD|379306
NZ_CP012069.2|WP_050341374.1|2516345_2517731_+|ATP-binding-protein	unknown	unknown	gnl|CDD|379306
NZ_CP012069.2|WP_157051513.1|2532661_2533036_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341409.1|2538866_2539136_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050341378.1|2518473_2519625_-|ATP-binding-protein	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	1.15662e-10
NZ_CP012069.2|WP_050341380.1|2519751_2520711_-|zinc-binding-dehydrogenase	gnl|CDD|176205	cd08243, quinone_oxidoreductase_like_1, Quinone oxidoreductase (QOR). NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	7.47866e-145
NZ_CP012069.2|WP_050341384.1|2521136_2522963_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.44753e-138
NZ_CP012069.2|WP_083443973.1|2533865_2534588_-|HD-domain-containing-protein	gnl|CDD|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	1.55149e-24
NZ_CP012069.2|WP_050341387.1|2526306_2527059_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl|CDD|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	1.02781e-13
NZ_CP012069.2|WP_050341386.1|2522956_2526310_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.31779e-123
NZ_CP012069.2|WP_050341398.1|2534999_2536106_-|Fic-family-protein	gnl|CDD|225718	COG3177, COG3177, Fic family protein [Function unknown].	9.43519e-23
NZ_CP012069.2|WP_050341391.1|2528054_2528816_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	2.28851e-09
NZ_CP012069.2|WP_050341404.1|2537550_2538288_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.29194e-87
NZ_CP012069.2|WP_050341411.1|2539275_2540190_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl|CDD|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	3.14479e-20
NZ_CP012069.2|WP_172674496.1|2529847_2532418_+|DUF2339-domain-containing-protein	gnl|CDD|378390	pfam10101, DUF2339, Predicted membrane protein (DUF2339). This domain, found in various hypothetical bacterial proteins, has no known function.	4.2497e-12
NZ_CP012069.2|WP_050341389.1|2527059_2527677_-|MptD-family-putative-ECF-transporter-S-component	gnl|CDD|370580	pfam09605, Trep_Strep, Hypothetical bacterial integral membrane protein (Trep_Strep). This family consists of strongly hydrophobic proteins about 190 amino acids in length with a strongly basic motif near the C-terminus. It is found in rather few species, but in paralogous families of 12 members in the oral pathogenic spirochaete Treponema denticola and 2 in Streptococcus pneumoniae R6.	1.95168e-33
NZ_CP012069.2|WP_083443971.1|2517994_2518510_-|DUF4143-domain-containing-protein	gnl|CDD|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	2.03338e-15
NZ_CP012069.2|WP_050341374.1|2516345_2517731_+|ATP-binding-protein	gnl|CDD|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	2.90324e-31

Protein sequences

>NZ_CP012069.2|WP_050341391.1|2528054_2528816_-|CPBP-family-intramembrane-metalloprotease
MNENTDLLQPRSASSGDGDTHGGSGEPVAPMPHLALALSLRFVLILLMGVCLHLAGQSLLWTDLGIIVVDAITFATLAHLMRGEGRRLRDLYVPTGGADIAWGLLFSLIIIVGFFVSTVLANLIVYHGAPPAQPSSFVPPLWLGALALAVMPLTIAFAEEGLYRSYLLPRLARRMGQVPALLLVSVFFGLQHIGFAVPDGQQMLSRALTTLFAGLLFGGLWLWKRKTVPLVIGHWLLDFLFLGLPVFYMATSA
>NZ_CP012069.2|WP_050341389.1|2527059_2527677_-|MptD-family-putative-ECF-transporter-S-component
MAQESQVQAATKGGGKLNTKDLIYAGAFCALYIVAMLIVVMGSGIVLPILYFIAPLTVGTVCGTIYMLYVLKIHKFGAALILGILFILATGHLTWYSLAVVLGASLIAELMIFLGKYTSKKMYLLSYVFFNLTMAAPYLSFVFNLQDSLKVTQDYYGEARAKAYETLFGSGFYVFTIALALVGGAVGALVASRLVKKHFAKAGIV
>NZ_CP012069.2|WP_050341387.1|2526306_2527059_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MEFELYGDDSGARIRFDPRTKLLVFFVSCFLSLSMHGNLPILVVGTLQCVMLTLSGKQALALKCLASLYVILFIRYCIEASGEQGAEAVVSVCMGLISLFVFFFPIMVSFLLLVRTTRVSQFLSAFQAMHLPMTLVIPLAVLFRFIPTVQDEWSGVRKAMAFRGISMTPGAIIRHPLLTIEYILVPLLFSSVGVMEELAAASLARGMDSTRKRSSFEDIQLGGADLIAISLFIIVAAWILAFRASGMSSL
>NZ_CP012069.2|WP_050341386.1|2522956_2526310_-|ATP-binding-cassette-domain-containing-protein
MIRFDDVSFHYGGESGTGDGVDHIDLTIADGAFTVLVGESGCGKTTLTRLINGLAPNFYEGEMEGAVYVDDICTTTAELHDTAALIGSVFQNPKSQFFNVDTTGELVFGCENQALSRDEMRRRLDRTRIDMQLDALMDRNIFELSGGEKQQIACGSVYASGPHVFVMDEPSANLDKKAIRRLHNILAKMKDEGKTIVLSEHRLHYLMDLADEFVYVKDGRIERTFSTQELRLLDDARLSELGLRCTDLRRLVRVRATSPAGGGPDGNGGKGQDGPYDDAYADARTVGRPALEAVDLSCSRGSARILDVDRIAFPVHSVVAVIGDNGCGKSTLAESLCGIIPSDGTVAIGGTFETARTRSKRSFMVMQDVNRQLFADDVAEEVSLNASVSEEEVDRVLEGLGLLEYKDRHPASLSGGQKQRVAIASALCAGKDILFYDEPTSGLDRRGMERFGTLLRAMRDKVLCSLIITHDPELILQCCTHVLHVRDGRAVALYPLDDEGAARVRGYFLSPSDESTSKRRDRTGAVGKILRYAGEQRRSIALAATLMIVGALASVVPYLLIYGLIDAALSGGTVTLAAAAPAVAAIAVCEVVHAASYTVGLVLSHKAAFSTLENLRKFLQERLDGQSIGTVRDLGAGAVKKLFTDDIESIELLLAHMIPEGAANITVVAVVLLTTFAVDWQMALLTLIVVGLGVIVSRQMYSVGIDKMGSYFAATKRLNNTIVEYVEGMEVVRVFNRQADSGEKFERAVSGYRDQALGWYKICWPWMALYGSLFSSVVLYSLPFGVLMVLLGRMTLSSCVLVLCLSFGIGPLLLHCMAFIGAIPQVSFKIQVLEKALDQAPLKSGSAGFVGRGHRVVFEDVRFAYRDAEVLKGISFTADEGRMTALVGESGSGKSTIARLLVHHYDVASGSISIGGQHIDDMTQVALSEQISYVSQDLFLFDRSILENIRVGRPDATDEEVIEAAKRAQCDDFIRDLENDYNTNAGTAGRRLSGGQRQRIAFARAILKDAPIVVLDEATAFVDPENEQRMSRAIREIIAGKTVIVIAHKLRSIAGADKIIMLHQGRVLAEGTQGELLSSCPEYRALWDASEQVSGWTLRDGGRIDAQGAGGREALSC
>NZ_CP012069.2|WP_050341384.1|2521136_2522963_-|ABC-transporter-ATP-binding-protein
MLGLVHRILAFSGPYARRVRIAYVFAFLRALCATAPLMLAIMALRLLMAGQATPLSCCLLAAGMLVLLLLQSIFQYLADRLQSGTGYEIFADKRVELGQHLRRLPMGFFTAGNIGRISSILSADMVYIEEQSMSIVANVMSDVFSQVILTVFLFTMSPLVGVIVLVVELIAVLVAQPMLAQARRNSDVRQRTIERLTDSVLEYVEGLAVVKSYNLTGEGAQDLRDSFATTRDTSLRFACEQSPFEAALLALYGLGSAAVLALSVWQLEQGAMTPGTFVGIALFLFQLFGPLRDLYQQSTRLTIMESALNRIESLFSQDELEDAGTDDLPDAAAAAALGSHEIEFSHVSFSYGEKNVLRDVSLAADCGQMVALVGQSGSGKTTLANLLARFWDVSAGQVLLRGVDVRRLPLSALMAQISMVFQNVYLFQDTVFNNIAMGRPGATREEVYEAARKACCLDFVMRMPYGFDTMVGEGGASLSGGEAQRVSIARAILKDAPIVVLDEATASIDADNERHIQQAMTELCRGKTTLVIAHKLPTIQNADRIAVVGDGQVLECGSHDELMALDGVYRRMVQAGERACGWDVAPVQGGAQPDDSRCGDGRGEEARR
>NZ_CP012069.2|WP_050341382.1|2520951_2521140_-|hypothetical-protein
MSEATQKMLGLVAIIISIFLLMGGLYLPADFVAEPTQTALVILGVMLLLGGNVVMVVAHNDE
>NZ_CP012069.2|WP_050341380.1|2519751_2520711_-|zinc-binding-dehydrogenase
MRAAVVFEAGGPEKLVVMEVPTPEVKPGWTLVRVRGFGINHSELFTRQGLSPSVRFPRILGIECVGGVAQTTDPDRLPQGQTVVSIMGEMGRAFDGGYAEYCLLPNEQVCPVEWDGDWATLAAIPETYYTAWLSLKNLRVESGNRLLVRGGTAGVGVAFSRLAHAARLSVTVCGTTRSVAKQERLLSAGFDDAVVDADGALQTDESFDRILELIGPKTLKDSCRHTTEGGIVCSTGLLGGKWYMDDDFSPIDDLPRNGYLTSAYSGNVSPSLMQELLDYIRERAVDVAPERVYTLDQVVDVHRYLESSHSFGKVVCVTG
>NZ_CP012069.2|WP_050341378.1|2518473_2519625_-|ATP-binding-protein
MPERQIYVNPFKPTAGMTPPVLVGRESVIDDFMDGLDEGPGAPGRLMRITGPRGSGKTVLLTALGNIATRRGWSVVNVSGKEALCASIQEQLVGDTRLRDLNVQISLPFVSAGAKIGDSGREPSFRDVFARATRSLSQDGAGLLITVDEAQDASRDDMAVIAANVQYMIREGQNVGLLFAGITTGVLDLLNGEGVTFLRRAQAEELASIPRADVARALRKTIEASGLAIEDAALAQAAADTCGYAYLIQLVGYYIWREGRRHVAESVTIDVEDVRRGTAAVRQYGQSMIETALAGLTKPALDYLLAMTEDNAASSTAAVARRMGKPAASANTYRRMLISRQVIEATAPGYVAFSMPFMREYLVKHEDDLLARYGASACQEPVR
>NZ_CP012069.2|WP_083443971.1|2517994_2518510_-|DUF4143-domain-containing-protein
MWGLSLSRACPVRPGHERTSVPDRRWAKHVTPLRPTSSLRRERTPDLLKGNLHVNLGSIMENVVAQELDAHGFKLHYFNAKRYGEVDFVVQDRRDVIPIEVKSGNDWASHPALDKLLKVSEWDLGHAYVLCKGNVRQSGAITYLPLYMSMFLEPRPHPETLPYEVDLSALG
>NZ_CP012069.2|WP_050341374.1|2516345_2517731_+|ATP-binding-protein
MEREAMSQLEAWMTSSRRKPLIVRGARQVGKTWLVREFAHRNFGALAHIVFLENEVMRAVFDGSLDPDRLLTAIGAYTGTNSLDGNTLVFLDEVQECPRALTALKMLCEQRPEVPVVAAGSLLGIALNRADDAQGNLARISWPVGKVEYLNMHPMTFREFLHAVGQGQLAELIRPDAIELVSAMGETYEDLLRSYLFTGGMPEAVQAYVDTRMLGAARNVQQRLLLDYEHDFAKHVRSASEAEHIRELWRSIPTQIARETGSNRFIYAQVKRGGRGRTYKDAVSWLTDSGLVTKVQRITRPNIPLRAYEDDSSFKLYLLDVGLLGAALHLDVRTILRGNELFTHAKGVYAEQYVCQQLVATDGIRPSATGSESQTTSMAPWYWSADGKRSKGEVDFLYECDGRVVPLEVKAGTSVKSGSIARFAKEHGITRSLRLSLKGYADQGWIVNYPLYAANLLPLVP
>NZ_CP012069.2|WP_172674496.1|2529847_2532418_+|DUF2339-domain-containing-protein
MQFLTECFVLVMLVLAAYCVSELRMCRREIDALKDWVRNLNSRVEVEEMRARGDQRESAAAPPQYGGSEQGPPIPAAWPYANESDAPSPWPYEHGVSSPWPNANAPVAPASWPYESGASTPLSSAPERPPVPGRPPAPISSSGQPPVPPGMIPAAPATFAAMPEDRDLAERSDSLEGTFGRNVIGLAAVLLVFLGLVFLGILVIPTLGNEVRCALMWLLSLVLASAGLAAARRRVSAFSISLLGAGMGAIFISVLMTHVYFRYLGEVPAFGLMLAWMAACMVLVRRFESTALSVLVHMGMVISVCFSYSFGFSETRLPLVITYQTLSCTLVVAGSVLCLRRTYRYGLLVSLVLTLIASLFMRDYFGVGGMGSRDTSLSTPIAVAFFLQFAGASVLSLLLALSGKEEEERDVTTTLYAMGKLAWFGVLLVDVCAVARQLILQASGLSASTVPPGNDAARAVMLAEAHSTLIGIACLAAGVALILWLMRKRLVDAELGKLSLCLLGGMAAFLLLLRYLSTHLSLLPQPNLSYVVLVAVYFYVLAYAMHDSAYASIGDVTLGLDALLMLTSGYGELVERAGVGTAFTYVVMLTALAYLSWRIRSRVVEAFGGDVEAPRLRPRMLTCLAVAELSIHIIVNAAGYQHAQEIVAGILAVLLVGVYALQAWRRRVASGTFWMGAAVNELAVSALVSLWALTGDAAGLLPSRPNSPDTYAYVPSLIILMALVGLRLWDFLSERPRPTEALQVAEGIVFSLLGLALTQCSTAQMDIPFAAGIVVMMTALICIIVGFKALLRALRLYGLTIVIVCVFRLVLVDAAFLSPVARVVSFVIGGAICFAISALYSRAEQRIRGRVGEGGK
>NZ_CP012069.2|WP_157051513.1|2532661_2533036_+|hypothetical-protein
MLNLYLNFYLRHQRAAATTCLLLGVFYAAGILCIDVLFTESTPNAARLLFVGCMLMGAVLFLISLFRARRDSSLWLPAHLCSMIGFGVGTGLAAGTTGAIACAMAAINGMCALAVLLLRVEQDS
>NZ_CP012069.2|WP_083443973.1|2533865_2534588_-|HD-domain-containing-protein
MCVDIGIENSLISSIKDTLDDRSGHGLDHVLRVRTLALLFADSEGADPDIVELASLLHDVDDYKLVGTNKSQELNNAKRFLENAGIGSKAYETILQIIRTIGFSKRLEGVRPSTIEGMVVSDADMCDAIGAEGILRVHKYGISRQIPFFNKLLVPEVNNLSADGYRNNSSKHSVQHFFDKLLRVPSMMLTETGRAEAKRRQAIMIDFLKELFREESSKDWSEFLASYLKNDPKVLPNVAL
>NZ_CP012069.2|WP_050341398.1|2534999_2536106_-|Fic-family-protein
MSFKQLETLHPVLARIDELQERVDEAKAAQPDAYDRIMESWAIESTYNSNNIEGSTLSLSDTALLYGGVQVDGLEDDIRQAEGGFAALRFLRSVVPGCAPLSEALIKRAHELVFAEAKDLATRGVYRKVEVEITGTSFQPAPSTYVPERMADLVEMCANTNRHPAIVAALFHLEFESIHPFVNANGRTGRLISNYLLMSSGFEPVNIQAESRARYIAAIRAFQEGDDPYPFAAFFCVNLVERQEKVLSLLVAGAADADAQAHSEIGVFLRDSADSSNEMPGGTPSSSDNHAKSSDNGGKSSDNLSASERKALSHMEGMESVRSSEVADLLGMSQRGAQKLLNRLVDKGLASSFGANRNRRYSVEKEHR
>NZ_CP012069.2|WP_050341400.1|2536213_2536420_+|hypothetical-protein
MSYSELVKSNADETDIRSYLTGGKQVAVTFRIPENLRESAKEAAELRGMSFSAFMRACMMDELSKKVL
>NZ_CP012069.2|WP_050341402.1|2536717_2537554_-|ABC-transporter-permease
MTHVLRMDVYRLLKSRLFYIILIILLMITVLCAVIADTSIHASPADTTSSTSEQNSIVIIDDSSVSEHDANHSNKVDFICDVFSGNIVAMTMIVFAALFAGAYRRTGYEKNVVCSVRRRWYFVASNAVICLLVCVLTVSLLLGASALSNTLIIAGYADLPFGSISKLGRFAVSYCALLVCATYVMSCFIRLCKNHVIGIVVALVYGSGIVYGIVNLALAPLLGPSFRIEAFLPLGTMYGLSVSMPDQAFCRAIVIALIFGTLSVAIDVMASNKRDIPC
>NZ_CP012069.2|WP_050341404.1|2537550_2538288_-|ATP-binding-cassette-domain-containing-protein
MSLAIVTKDIVKKYDGQNVLDKVSLSVLEGDIYGLVGRNGAGKTTFMKIVCGLSSPTSGSMSILGADPLTKGSESFSKIGSLIETPCFFPYMNATDNLMLKCICCGIDAPDKHIKELLELVGLQNVRNKHTRDFSLGMRQRLGLAMALIGNPELLVLDEPINGLDPQGIAEIRSLILKINRETGTTIVISSHILSELSKVATRYGILDCGKLVYENSREALEAECENKDMSFEDFYFQITQGDGR
>NZ_CP012069.2|WP_157051515.1|2538435_2538609_-|hypothetical-protein
MTGREIRSTGHISQRSTKLAGEAADKAGLTWGDVADMPGREACGLLFPAQGEARDAS
>NZ_CP012069.2|WP_050341409.1|2538866_2539136_-|hypothetical-protein
MSLFSVRACEQGKRLPEEMPSDFGISDANAAFRHLLELAHLFGLRSVRSADVVVLAHAGCKKPINKPFRDWHFAWVELQENGDEAAYQN
>NZ_CP012069.2|WP_050341411.1|2539275_2540190_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MTYENGGQFDRALKKAIRNSGGDPGDGYRQALRDRFLCRVFSDPDERFILKGGSGLLARIPDGRATRDIDFVTASRESPEAALTALVALAGKDMGDFLTFKLDKWEESLDENGYSRLLKLRFQTFLGHEEKDPILVDLSLDCSITQPAERISPANRVCVEGLESCGYLVYPLPDQLADKLCAIMEMQPGGWPSSRMKDLVDVVYYSTNVTLLLKDLVRSIKCECSRRGMSVPRRFEAPAAWAGSFAAFAKKSGVPEKYAPFEAASSLASAFFDPALRGFFGHDASWDPESLRWRQEGSAETKER

Crispr_ID: NZ_CP012069_29

• CRISPR_ID: NZ_CP012069_29
• CRISPR_location: 2678209-2678380
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_29

Consensus_repeat	Method
GCCACTCGGTGGCGTCGAGTGCGCAGTCTGCGTGCCACTCGGTG	CRISPRCasFinder

spacers of NZ_CP012069_29

>29.1|2678253|84|NZ_CP012069|CRISPRCasFinder
GCGTCGAGTGCGCAGTCTGCGTGCCACTCGGTGACAGCGAATGGCACGACATTTCTTGGCAACTGCGCATATGCCGACTTTCGC

CRISPR arrays and Neighbor proteins around NZ_CP012069_29

CRISPR arrays

The CRISPR arrays of NZ_CP012069_29

>merge|NZ_CP012069|29|2678209-2678380|CRISPRCasFinder
TACGCGCACAGGCGCCGAGTGCGCAGTCTGCCTGCCACTCGGTGGCGTCGAGTGCGCAGTCTGCGTGCCACTCGGTGACAGCGAATGGCACGACATTTCTTGGCAACTGCGCATATGCCGACTTTCGCGCCACTCGGTGGCGTCGAGTGCGCAGTCTGCGTGCCACTCGGTG

>NZ_CP012069|29|26|2678209-2678380|CRISPRCasFinder
TACGCGCACAGGCGCCGAGTGCGCAGTCTGCCTGCCACTCGGTG	GCGTCGAGTGCGCAGTCTGCGTGCCACTCGGTGACAGCGAATGGCACGACATTTCTTGGCAACTGCGCATATGCCGACTTTCGC
GCCACTCGGTGGCGTCGAGTGCGCAGTCTGCGTGCCACTCGGTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_157051526.1|2679362_2681144_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_050341595.1|2678591_2679317_+|aquaporin-family-protein	unknown	unknown	gnl|CDD|223653
NZ_CP012069.2|WP_050341599.1|2695316_2696225_-|NTP-transferase-domain-containing-protein	unknown	unknown	gnl|CDD|133021
NZ_CP012069.2|WP_050341590.1|2670136_2670517_-|RidA-family-protein	unknown	unknown	gnl|CDD|129116
NZ_CP012069.2|WP_050341596.1|2681136_2682960_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_083443998.1|2673672_2675919_-|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl|CDD|236137
NZ_CP012069.2|WP_083443999.1|2676134_2677208_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP012069.2|WP_050341585.1|2666322_2667201_-|class-B-sortase	unknown	unknown	gnl|CDD|320675
NZ_CP012069.2|WP_083444001.1|2696393_2696870_-|metal-dependent-transcriptional-regulator	unknown	unknown	gnl|CDD|224240
NZ_CP012069.2|WP_083444109.1|2673289_2673580_+|acylphosphatase	unknown	unknown	gnl|CDD|376373
NZ_CP012069.2|WP_050341581.1|2664255_2665644_-|DUF4013-domain-containing-protein	unknown	unknown	gnl|CDD|379068
NZ_CP012069.2|WP_050341583.1|2665724_2665997_-|N-acetyltransferase	unknown	unknown	gnl|CDD|379642
NZ_CP012069.2|WP_050341601.1|2697016_2698306_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl|CDD|236486
NZ_CP012069.2|WP_050341604.1|2700257_2701172_-|ATP-synthase-F1-subunit-gamma	unknown	unknown	gnl|CDD|376304
NZ_CP012069.2|WP_050341597.1|2693895_2695305_-|hypothetical-protein	unknown	unknown	gnl|CDD|100093
NZ_CP012069.2|WP_050341589.1|2669060_2669750_-|hypothetical-protein	unknown	unknown	gnl|CDD|379921
NZ_CP012069.2|WP_083443997.1|2670942_2671920_-|transposase	unknown	unknown	gnl|CDD|307151
NZ_CP012069.2|WP_050341594.1|2677250_2678198_-|DMT-family-transporter	unknown	unknown	gnl|CDD|223769
NZ_CP012069.2|WP_050341603.1|2698340_2698772_-|ATP-synthase-F1-subunit-epsilon	unknown	unknown	gnl|CDD|213395
NZ_CP012069.2|WP_050344566.1|2698782_2700204_-|F0F1-ATP-synthase-subunit-beta	unknown	unknown	gnl|CDD|236447

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_157051526.1|2679362_2681144_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.47557e-127
NZ_CP012069.2|WP_050341595.1|2678591_2679317_+|aquaporin-family-protein	gnl|CDD|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	1.44376e-42
NZ_CP012069.2|WP_050341599.1|2695316_2696225_-|NTP-transferase-domain-containing-protein	gnl|CDD|133021	cd02541, UGPase_prokaryotic, Prokaryotic UGPase catalyses the synthesis of UDP-glucose. Prokaryotic UDP-Glucose Pyrophosphorylase (UGPase) catalyzes a reversible production of UDP-Glucose and pyrophosphate (PPi) from glucose-1-phosphate and UTP. UDP-glucose plays pivotal roles in galactose utilization, in glycogen synthesis, and in the synthesis of the carbohydrate moieties of glycolipids , glycoproteins , and proteoglycans. UGPase is found in both prokaryotes and eukaryotes, although prokaryotic and eukaryotic forms of UGPase catalyze the same reaction, they share low sequence similarity.	1.16459e-110
NZ_CP012069.2|WP_050341590.1|2670136_2670517_-|RidA-family-protein	gnl|CDD|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	1.05859e-57
NZ_CP012069.2|WP_050341596.1|2681136_2682960_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.46532e-162
NZ_CP012069.2|WP_083443998.1|2673672_2675919_-|NAD-dependent-DNA-ligase-LigA	gnl|CDD|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NZ_CP012069.2|WP_083443999.1|2676134_2677208_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	5.48239e-49
NZ_CP012069.2|WP_050341585.1|2666322_2667201_-|class-B-sortase	gnl|CDD|320675	cd05826, Sortase_B, Sortase domain found in class B sortases. Class B sortases are membrane-bound cysteine transpeptidases broadly distributed in Gram-positive bacteria (mainly present in Firmicutes and Actinobacteria). They can have radically distinct functions. Some members of this group attach haemoproteins to the peptidoglycan of the cell wall, while others assemble pili, which are multi-subunit hair-like fibres that extend from the cell surface to promote microbial adhesion and biofilm formation. In transpeptidation reaction, the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class B sortases normally recognize the consensus NP[Q/K][T/S][N/G/S][D/A] motif), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase B protein from Staphylococcus aureus (named Sa-SrtB) cleaves surface protein precursors between threonine and asparagine at a conserved NPQTN motif with subsequent covalent linkage to pentaglycine cross-bridges. It is required for anchoring the heme-iron binding surface protein IsdC to the cell wall envelope. SrtB contains an N-terminal hydrophobic region that functions as a signal peptide/transmembrane domain. At the C terminus, it contains an essential cysteine residue within the catalytic TLXTC signature sequence, where X is usually a serine. Genes encoding SrtB and its targets are generally clustered in the same locus. The prototypical class B sortase involved in pilus biogenesis is pilus-specific sortase C2 from Streptococcus pyogenes (named Sp-SrtC2) that anchors a surface protein containing a QVPTGV motif to the cell wall, as well as polymerizes the major pilin subunit Tee3/FctA and attaches the minor tip pilin Cpa. The linkage of Cpa to Tee3 by SrtC2 requires the VPPTG motif in the cell wall-sorting signal of Cpa. The family also includes SrtB enzymes from Bacillus anthracis (named Ba-SrtB) and Clostridium difficile (named Cd-SrtB). Ba-SrtB is thought to recognize the NPKTG motif, and attaches surface proteins to meso-diaminopimelic acid (mDAP) cross-bridges. Cd-SrtB does not play an essential role in pathogenesis. It cleaves short [SP]PXTG motif-containing peptides between the threonine and glycine residues and then covalently anchors the threonine residue to a nucleophile such as glycine or mDAP, but not to the peptidoglycan of C. difficile, suggesting a novel association of sortase activity with cyclic diGMP (c-diGMP)-mediated regulation to control levels of cell wall anchoring and secretion of putative adhesion molecules.	4.11519e-58
NZ_CP012069.2|WP_083444001.1|2696393_2696870_-|metal-dependent-transcriptional-regulator	gnl|CDD|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	1.14769e-28
NZ_CP012069.2|WP_083444109.1|2673289_2673580_+|acylphosphatase	gnl|CDD|376373	pfam00708, Acylphosphatase, Acylphosphatase.	3.64131e-22
NZ_CP012069.2|WP_050341581.1|2664255_2665644_-|DUF4013-domain-containing-protein	gnl|CDD|379068	pfam13197, DUF4013, Protein of unknown function (DUF4013). This is a family of uncharacterized proteins that is found in archaea and bacteria.	1.98467e-13
NZ_CP012069.2|WP_050341583.1|2665724_2665997_-|N-acetyltransferase	gnl|CDD|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	3.27043e-25
NZ_CP012069.2|WP_050341601.1|2697016_2698306_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl|CDD|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NZ_CP012069.2|WP_050341604.1|2700257_2701172_-|ATP-synthase-F1-subunit-gamma	gnl|CDD|376304	pfam00231, ATP-synt, ATP synthase.	6.11122e-109
NZ_CP012069.2|WP_050341597.1|2693895_2695305_-|hypothetical-protein	gnl|CDD|100093	cd05800, PGM_like2, This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four structural domains (subdomains) with a centrally located active site formed by four loops, one from each subdomain. All four subdomains are included in this alignment model.	2.36358e-128
NZ_CP012069.2|WP_050341589.1|2669060_2669750_-|hypothetical-protein	gnl|CDD|379921	pfam17117, DUF5104, Domain of unknown function (DUF5104). This is a family of gut microbes of unknown function.	4.97736e-05
NZ_CP012069.2|WP_083443997.1|2670942_2671920_-|transposase	gnl|CDD|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	5.47689e-47
NZ_CP012069.2|WP_050341594.1|2677250_2678198_-|DMT-family-transporter	gnl|CDD|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	3.64077e-15
NZ_CP012069.2|WP_050341603.1|2698340_2698772_-|ATP-synthase-F1-subunit-epsilon	gnl|CDD|213395	cd12152, F1-ATPase_delta, mitochondrial ATP synthase delta subunit. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient. The extrinisic membrane domain, F1, is composed of alpha, beta, gamma, delta, and epsilon subunits with a stoichiometry of 3:3:1:1:1. Alpha and beta subunit form the globular catalytic moiety, a hexameric ring of alternating subunits. Gamma, delta and epsilon subunits form a stalk, connecting F1 to F0, the integral membrane proton translocating domain. In bacteria, which is lacking a eukaryotic epsilon subunit homolog, this subunit is called the epsilon subunit.	4.46696e-26
NZ_CP012069.2|WP_050344566.1|2698782_2700204_-|F0F1-ATP-synthase-subunit-beta	gnl|CDD|236447	PRK09280, PRK09280, F0F1 ATP synthase subunit beta; Validated.	0

Protein sequences

>NZ_CP012069.2|WP_050341594.1|2677250_2678198_-|DMT-family-transporter
MRLPKNIPVWAFECAIALSALIWGASFVVVKGALDAVTPGWLVTIRFAVAGLVLSVIFWRRLHNYLDVSHVLAGVMIGVPAGLAYLIQNVGLVGTTPGRNAFLTTTYCVMVPFFNWALLRRRPGANNVAAALMALVGVGLLSLGDSGADLSPSLSSGDALTLVSACFFALNIVAVGRYAAAHDYAVITIVMFAVSSLICAVYALVAEPLPDLAAMPADFWWQMSYVALLSTALATLLQNLAQRHVEPSKAALLFSLESVFAVAFSVLLYGERLTPRLVAGFALIFFAVLVSELVVSRGGARAGRQEGDRDARAGR
>NZ_CP012069.2|WP_083443999.1|2676134_2677208_+|Gfo/Idh/MocA-family-oxidoreductase
MSAKPSGQKATRSVSARQVPATRASRRLSLGHAPYLHWGVIGCGVIANQMAEALALQGRQLDGVANRTPSKAHDFADKHGVKRCYETIDELIGSPDIDAIWLTTPHNTHIHFLRQALTAGKHVLCEKSITLNGGELREAIDLAKRTGVQLMDANTILHMPLYRALTRRLAAGEFGPMNLVQLNFGSYKAYDMENRFFNPQLAGGALLDIGVYAATLARLFMMSGPDDVVSIMNAAPTGVDETSGIVMRNPQGQMATMTLSLHSKQPKRAMISCDKCYIEIMEYPRADSARIVWTSDGHVEAFSAGTTDYALCYEMADMEAAVAGDVETRGLMRITLDVMDLMDRLRRDWQFRYPEEQ
>NZ_CP012069.2|WP_083443998.1|2673672_2675919_-|NAD-dependent-DNA-ligase-LigA
MTDERDLGAQGSPFTDARPRPEGAGEAGQGAIPTSGQSLRERAAELNRVLEHAAYAYYALDEPEMSDAEFDRRLQELIALEAEHPELVSPDSYTQRIGGYVSRQFEPVLHARRMYSIDDAMGLAELDEWLARTDEALGATAAQPVAYTCELKIDGLGIALTYTNGQLLRAATRGDGTTGENVTANALTIKDIPRALKPAGLARVADGGLGQSVEVRGEVYMPKASFVRLNEESDAAGRAPFANPRNAAAGSLRQKNAKITRSRDLRTFIYAVADERPLQVSTQHDFLTWLSDCGFSVNPHARLVQSSAEVHAYCQDALTHREELDYDIDGVVVKVDSFASQGALGFTARAPRWSVALKFPPEERRTILRAIRVQVGRTGVLTPVAEFDPVVVAGSTIARATLHNIDELRRKDVREGDTIVVHKAGDVIPEVVGPVTEGDLAVEHEARPLWQMPERCPACGSPVVREEGEVAYRCLSLDCPAQATERLIHWGSRAAMDIDGLGDELVGRMVEQGLLADVADYYDKLSVDVLAAVDSGRRYETSTRDHRKGDPIVLGATIATKVMGQVEASKQAGLARVLFGLGIRHVGANVASLLATHFGSMQALTLASEEDIAVIDGIGPKIAEAVREFLSIPRNLAVIERLRKAGVSLEQEGFGQLPQRPQSLSGLSFVLTGTLEGHSRSEATARLKELGAKVSGSVSKRTSFVVAGAAAGSKLTKAQDLGVPVLDEAALDRILETGEPPAGGRPGE
>NZ_CP012069.2|WP_083444109.1|2673289_2673580_+|acylphosphatase
MDGLIRWRLRYTGRVQGVGFRFTVRGLARECKVTGWVKNLDDGDVLIEAQGTPDQVSALTDAIKRESARERTWVRATLATREELAPQQEQDFRIVH
>NZ_CP012069.2|WP_083443997.1|2670942_2671920_-|transposase
MAPWPPPSPRRARPAPRPTRPGGWPPSSGAGSPPRDQVSRLCAAVDGEVDAFLARDWSAMRLDCLFLDATYAGCRVSGRVRSEALVTAIGVGDDGRRRLVGLACANAESYASWRGFLQDLEGRGVRNVRLVTSDAHDGLAGAIREVYPEATWQRRVVHARRDVLAKIDGREAQRRARAAVSPILGESDPTLVRAPCHEAVDELASFAPDASRVLEDAEVDALAYLSFPREHRAEIRTNNARERTSRGHKRRAKGRPDVPVDGVRSAPARRHRGRGGRRLGIREPVHVEGVPQARPGAREGRESHRGVRPERGGEGARRGHHDGGA
>NZ_CP012069.2|WP_050341590.1|2670136_2670517_-|RidA-family-protein
MEKTAIVTDKAPAALGPYSAAIKVKDSIHVSGQIPIDPATGELVAADIKGQTRQSLTNIKNILEAAGSSMCDVVETTVLLTDIDEFGPMNEVYAEFFSKPYPARAAFQVVALPKGAKVEIKATARV
>NZ_CP012069.2|WP_050341589.1|2669060_2669750_-|hypothetical-protein
MVRRSLIAAALSLACALLQGGCSLPRTDSAIGGELSSELLRRLNEDDVAGVEAMFCEASRARPELRGEIERGMAFFEGRVETDKRRSYLFGLVSFSDNDWRVLSASSQSVDHGRVLEYYVNPHITGIVTDAGKRYEMYIYYYETCVGHEDLEGVSEIYIWEVLRDGTRGEKCVIGQYLDPSRPPEPREEDTTRHDWGPTQDTGEREGTRSAGLSDQQIAEPCADHGAVL
>NZ_CP012069.2|WP_050341585.1|2666322_2667201_-|class-B-sortase
MLKQVLTQMWQALRQRTMAWGARPRMVIVAVATLVLVVAAAAVTLHPPVSPSVAEEKQRAAEDPVPTVSTDSDEGEGEETTDVENAVDFSKLKEENQDIYAWITIPGTNVNNPVLQSPDDDTYYLDHNRSGKASPYGAIFSQSMNALDFSDPVTVLYGHNTDDPIHLFRSLHNFEDANFFAEHDVMYVFTPGRVFIYKIVAAYEYDDRHILNSFDFKNPQALQEYYNFVLNPESSRRNIREGATLDAATDKILQLSTCMVEEYHGPHRFIVTGVLKDNRPIDSQSAINLSTL
>NZ_CP012069.2|WP_050341583.1|2665724_2665997_-|N-acetyltransferase
MTFKVSADKICCMADEGVELGHIELHQLTPDTVDIIHTFVEPAGRGQGIAGRLCQRLAEELRDRGMRARLSCSYAQGWFEKHEEFSDVVA
>NZ_CP012069.2|WP_050341581.1|2664255_2665644_-|DUF4013-domain-containing-protein
MRETRYLSHAWGLLTRDRGWYTPILTLSVYMLVPVVGWLVVLGYEMEWARRVAWGFEGPPQRRGIDIPRCFQSGCRAFVAVLGWCIVWVVLYCAVAMAVTRSYLGPLADALDTLMLIRMLPWLLLSVWSPVGWPLIAVVSFCTVLTVMVGVRATIYQDSAAGYQISRIVEMIKRDAGGYAKISGLVALVALVCEFAPLLLSYVFAFIGVFLGLAGSVLFVLFLYPVIFLLMAVYCTVVFLLIHTMVGLWMRQFDVPSWGKSTDSLPAGRQPSSDARLGSLGGGDQHAAQPYQLGQSQLQGQGPGDQLQGQNASPAPGAASGVRPPDVEWGLSASAGLSRADQAGTPSSRPVDGGDISSFPNASAPSDRPSPIDFTDPVSLAIEALASQSPQSAGPRTAPQSPQTVESHAASQSLQTVESHAASQSSQTAELHAASQSPQSADAQTSLGPETNGEDVRPNEDQ
>NZ_CP012069.2|WP_050341595.1|2678591_2679317_+|aquaporin-family-protein
MSHNILAEFGSTALMIIFGVGVHCDTVLKGTKYQGSGHMFAITTWSFGITVALFVFGGAVCMNPAMALAQCMLGLVPWDMFVPYAVAEMLGGFAGAVIAWFMYADDFKASEGVIDPIAQRNIFSTNPIVQNIPRDFFCEAICTFVFITAILATAARAGENVLLLAIGVGLIVWAVGMGMGGITGFAMNQARDLGPRLAYQLLPIKDKADNNWSYGLLVPGIAPFVGAALAAFFVHGFLGLF
>NZ_CP012069.2|WP_157051526.1|2679362_2681144_+|ATP-binding-cassette-domain-containing-protein
MGSAGTAQGREYSKRTSLRLLRELLGPYKGLAAATLALLLIDVVGMLYVPTELSALVNTAVSGGSHHALVTHGLVMLVSALAGSGGCIASYWFASRLAARVGRDLRVRVYEQSLSLTSFEFSQLGTGSMITRTLSDANVVQQTLVMSFLMLAPLPVICVVAIVLAYGTDAIMGHLLLVVTLTMLAISAVAVTRSAPIFLRLQEFIDHMNSRLRESITGMRVIRAFGKEAHERTRLGKTFEEYAKNAIRVNLVFSITDASCFFLMNVAEFAVMWLGADRVGAHAMQIGSITAFVQYVILILFFTMMAQFAILQLPRAMACLTRAAEVLDIRPSILDPATKVTTLPHSELIARFDHVSFRFADASEDTLHDLCLSLRRGQMTAIIGNTGSGKSTIAKMLLRFNDVSSGKLCVLGADVRSLTQAQLRTHMAYVPQKAWLFSGTIAENLRDADPQASDERLWHAIGVAQADFVRELPDGLDAPVAQGGTNFSGGQRQRLAIARALVRRADLYIFDDSFSALDYRTDAALRHALSHELAGAAVLIIAQRVSTIREAAQIVVLKEGRIVGVGTHEMLMGDCKDYRSIVESQERGGTLDG
>NZ_CP012069.2|WP_050341596.1|2681136_2682960_+|ABC-transporter-ATP-binding-protein
MASELEQGQKADALDEERPAHALNTARRLWEVAAGQRWRLVVSAISTVLYVVGTLAAVSYSALLVDRLWESIQATFAAGKTYTLTLDNGGREVLCYLGIWSLAWVFYATQTLVMASFAERLNLQLRERIADKLALLPLSYFDAHKPGDTISHATNDLDKISEVMQRGLLQLIIASCTLIGSVIMMGLHNLMLTGIFLAFSLAAFVATKVVSAKTLAIAARRQAVLGELTGGIEEAYSGRLVIKAFGRESASLASVSAKSDELAHVSSWADFITNAVSPAIRLLGKLSQVVIGILAGNLLLAGQMTVGVFQAFFQYMTEASEPLTELSFSINSLQGALAAAERVFKLLDEAEVTPDPVEPTRLNKPVLGRVAFEHVRFDYSPDKPLMSDISLAAEPGQKVAIVGATGAGKTTLINLLMRFYEVDDGRITLDGVDTRQLTRKDLRRQFGMVLQDAWLFEGSIATNIAYGKPDATREEVEAAARAARVDFFVRTLPKGYDTWLDNDAENVSQGQRQLLTIARAMLCDPAILILDEATSSVDTRTEQAITRAMEAIIEGRTSFVIAHRLSTIVDADLILVMEQGTIVEQGTHEELLAAGGSYAELYRSQFA
>NZ_CP012069.2|WP_050341597.1|2693895_2695305_-|hypothetical-protein
MRALSFGVSGWTARFDNGFDETSVSSIAAALGQLWSRRHGGATVAVGYDTRHDSQGYATLVGSILAAYGLTVRVSVSACPSPALCCAVAADPACIGGVRVSGSDAPCEYGGISVCGSDGGSVSQRFAKAVDQLVGVAAPVSMDEFDTADLMGPYKACLNRVIRPPDAPHRTLKIVVDPMHGVGAQPLLPLLKELGCDVTLMHGEQREDFGGLHPEAAEPWVDDCEAAVVQGGADLGIVLDGDAMRSAVIDAQGTLVTPHKLIPVLLDHLVRSRRMSGRVVCTMASSAQIRLEAERLGLGFTAVPVGFDRIHDELLDGDVLLGCEEFGGVCLPIHLPERDGTLVALLVVESLLRSGQSLAEAVSELEAQIGPMSYGRRDMRLDPAKLRTLSNALPGLNPGVVAGEQPRHVSHADGLKLEFFDDSWLMVRPSRREPTVRIYAEAHSVRRRDKLLNVAIDYVEGGYQQDLLR
>NZ_CP012069.2|WP_050341599.1|2695316_2696225_-|NTP-transferase-domain-containing-protein
MKAVIPAAGLGTRFLPATKGTPKELLPVLNKPVIQYVVEEALEPEGVDGVIIVNSHEKPQIESYFKVDGGFEDILRRRGKLREADSVHEAASLPVSFVYQDEPRGLGHAVLCAAAATGDEPFFVLLGDYFVPDHQMCVNMKRVSDERGGAPVIAVAPVPPDQVNRYGIIAGECVGSLAGGELVDSEAQGAVWKISGLVEKPAPADAPSHLFIVGRYLLTPRVMELLEDQGVGAGGEIQLTDAMQRLLAEQDMYALVVEREEGCDTGTPAAWAATNAKLALLDESTRLAFTEALGTKASALLG
>NZ_CP012069.2|WP_083444001.1|2696393_2696870_-|metal-dependent-transcriptional-regulator
MESAVERKRPRAGSDDACLAAKNRPGSHRLSMANEDYLEAIYRVMEEAGDFSGARSVDVADRLGVSKASVNKAVSTLKDAGYVAQNHYGRVRLTDAGRVYASHVWRCHRMLRSFLERDLGVDHETADAEACLMEHALSRDTQLKWLGYLEKQGIAIED
>NZ_CP012069.2|WP_050341601.1|2697016_2698306_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MEVIRVKGGRSIEGEVTVEGAKNSALKLMAATLMAPGVNTLTNVPNIADVHVMGKVLKYLGARIEVLGEHELKIDTSSVDRWETPYHLVAQMRASTAVLGPLLSRFGKAIVAMPGGCNIGARKIDMHILGLESLGVNFDVDHGDIHASIPHGLKGTQVMLDFASVGATENLMMASVHVTGTTVIENAAREPEIVDLANLLNEMGAKVSGAGSSRIEIEGVEELHPVEHRVVGDRIEAGTFIAMAGICGGPVTVKGFDPAHLGLVLKKYELMGLDVERGRHECTVSRQAPIRSIDIQTLPFPGFPTDLQAQTMCLLAQGSDSCIVTENVFENRFMFASELQRMGADITIEGHHAIVRGVERFSGAEVKSPDLRGGAALVMAGLVADGYTTVSDVHHIDRGYECFVEKLQALGAEVRRMEVPDLEDGGEVG
>NZ_CP012069.2|WP_050341603.1|2698340_2698772_-|ATP-synthase-F1-subunit-epsilon
MAELSCQFVRPDRLLYEGPVASLILVTESGELGVWPGHAAEICALGDGVVRLHLRETDGGGTVKVIISGGYVEIDGKDVIILADHARRTDDIDPDQVRDTREAAFDTRDALPEGDHRRAYWDNKIKWCNLLLKHAERSGNEVA
>NZ_CP012069.2|WP_050344566.1|2698782_2700204_-|F0F1-ATP-synthase-subunit-beta
MYQSVGTGKIIRIVGPVVDVKFDGKVPAIYTALVVDGDTPVGKVHTVLEVESQLADGVVRSVAMSSTDGLQRGLMVHDTGRPMMMPVGPFTLGRVWNVMGQPVDGKGIPEDVLYYPIHHPAPPFEDLTTTTEVFETGIKAIDLLEPYVRGGKTGLFGGAGVGKTVLIQELINNLAQEHGGTSVFTGVGERTREGTDLYLEMTESGVINKTCLVYGQMNEPPGARLRVGLAGLTTAEYFRDQGQDVLLFIDNIFRFSQAGSEVSALLGRMPSAVGYQPTLATEMGDLQERITSTKEGSITSVQAVYVPADDLTDPAPATTFTHLDATTVLSRAITELGIYPAVDPLASSSSALDPSVVGDEHYRVAMAVQETLQEYSDLQDIIAILGMDELSEEQQLVVSRARKIQQFLSQSFHVAEKFTGNPGVYCSVEDTVRSFAAIIDGQCDDIPEQAFRFAGSIDDVRRRASTMSAGKQG
>NZ_CP012069.2|WP_050341604.1|2700257_2701172_-|ATP-synthase-F1-subunit-gamma
MANLREIQRRMSSIKSTMQITRTMEMISTARIQKALLRAEDASPYKDAITHMLAHVASAGFDDSQPLLQRHREERSVLFVLIASDRGLAGGFNILQQRLVEQQMRDLAARNVKSSVITCGRKPTEYFTYRKIPPVLSFVGTSSEPTHDEADRIASYVMDGYASGKLDRVMIMYWHAKNRVDQVQVSEQILPVSRERLMMPNRPRTPEALSQVEHEAYTDYAFEPSAHEVMDYLMPAYIRTVIFHALLDSAAAEHGARRRAMQSATDNAKEVLGSLGRSYNRERQGAITTELNEIIGGASALEDM

Crispr_ID: NZ_CP012069_30

• CRISPR_ID: NZ_CP012069_30
• CRISPR_location: 2716451-2716536
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_30

Consensus_repeat	Method
CCCCGCAGCCTGGCGGGGGGTTGC	CRISPRCasFinder

spacers of NZ_CP012069_30

>30.1|2716475|38|NZ_CP012069|CRISPRCasFinder
TCGAGCGCATTTGCCCAGTTGAGGCATTCTCTATAGTG

CRISPR arrays and Neighbor proteins around NZ_CP012069_30

CRISPR arrays

The CRISPR arrays of NZ_CP012069_30

>merge|NZ_CP012069|30|2716451-2716536|CRISPRCasFinder
CCCCGCAGCCTGGCGGGGGGTTGCTCGAGCGCATTTGCCCAGTTGAGGCATTCTCTATAGTGCCCCGCAGCCTGGCGGGGGGGTTG

>NZ_CP012069|30|27|2716451-2716536|CRISPRCasFinder
CCCCGCAGCCTGGCGGGGGGTTGC	TCGAGCGCATTTGCCCAGTTGAGGCATTCTCTATAGTG
CCCCGCAGCCTGGCGGGGGGGTTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050341619.1|2708382_2709630_-|amidohydrolase-family-protein	unknown	unknown	gnl|CDD|238624
NZ_CP012069.2|WP_050341625.1|2712782_2714426_-|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|378796
NZ_CP012069.2|WP_050341640.1|2724916_2725240_+|metal-sensing-transcriptional-repressor	unknown	unknown	gnl|CDD|197391
NZ_CP012069.2|WP_050344569.1|2719390_2720986_-|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NZ_CP012069.2|WP_050341613.1|2705591_2706233_-|uracil-phosphoribosyltransferase	unknown	unknown	gnl|CDD|234653
NZ_CP012069.2|WP_157051603.1|2722258_2723065_-|lantibiotic-ABC-transporter-permease	unknown	unknown	gnl|CDD|163445
NZ_CP012069.2|WP_050344570.1|2723127_2723925_-|bacteriocin-ABC-transporter-permease	unknown	unknown	gnl|CDD|274754
NZ_CP012069.2|WP_050341634.1|2721822_2722245_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341628.1|2715309_2715765_-|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|224511
NZ_CP012069.2|WP_050341630.1|2717238_2718609_-|ATP-binding-protein	unknown	unknown	gnl|CDD|224292
NZ_CP012069.2|WP_050341626.1|2714633_2715308_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_172674532.1|2706303_2707560_-|serine-hydroxymethyltransferase	unknown	unknown	gnl|CDD|234571
NZ_CP012069.2|WP_050341611.1|2705097_2705385_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341644.1|2728291_2728870_+|biotin-transporter-BioY	unknown	unknown	gnl|CDD|376871
NZ_CP012069.2|WP_050341621.1|2709917_2711048_-|GTP-binding-protein	unknown	unknown	gnl|CDD|223597
NZ_CP012069.2|WP_050341632.1|2721000_2721663_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NZ_CP012069.2|WP_050341617.1|2707642_2708122_-|ribose-5-phosphate-isomerase-B	unknown	unknown	gnl|CDD|376799
NZ_CP012069.2|WP_050341638.1|2723954_2724668_-|lantibiotic-protection-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|163452
NZ_CP012069.2|WP_050341642.1|2725327_2727967_+|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319783
NZ_CP012069.2|WP_050341623.1|2711121_2712573_-|APC-family-permease	unknown	unknown	gnl|CDD|223605

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050341619.1|2708382_2709630_-|amidohydrolase-family-protein	gnl|CDD|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	5.96056e-91
NZ_CP012069.2|WP_050341625.1|2712782_2714426_-|VWA-domain-containing-protein	gnl|CDD|378796	pfam12034, DUF3520, Domain of unknown function (DUF3520). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is about 180 amino acids in length. This domain is found associated with pfam00092.	6.39301e-70
NZ_CP012069.2|WP_050344569.1|2719390_2720986_-|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.84887e-32
NZ_CP012069.2|WP_050341613.1|2705591_2706233_-|uracil-phosphoribosyltransferase	gnl|CDD|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	5.52243e-121
NZ_CP012069.2|WP_050344570.1|2723127_2723925_-|bacteriocin-ABC-transporter-permease	gnl|CDD|274754	TIGR03732, lanti_perm_MutE, lantibiotic protection ABC transporter permease subunit, MutE/EpiE family. Model TIGR03731 represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family is largely restricted to gallidermin-family lantibiotic cassettes, but also include orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes. In most species, this subunit is paralogous to an adjacent gene, modeled separately.	1.44391e-19
NZ_CP012069.2|WP_050341640.1|2724916_2725240_+|metal-sensing-transcriptional-repressor	gnl|CDD|197391	cd10156, FpFrmR-Cterm-like_DUF156, C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156. This domain family contains the C-terminal domain of the functionally uncharacterized protein Faecalibacterium prausnitzii A2-165 FrmR, and related domains. This family is part of a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes CsoRs (copper-sensitive operon repressors). CsoRs form homotetramers (dimer of dimers). In Mycobacterium tuberculosis CsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family, and a conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are also conserved.	1.22574e-42
NZ_CP012069.2|WP_050341628.1|2715309_2715765_-|RNA-polymerase-sigma-factor	gnl|CDD|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	5.16587e-34
NZ_CP012069.2|WP_050341630.1|2717238_2718609_-|ATP-binding-protein	gnl|CDD|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	1.38075e-21
NZ_CP012069.2|WP_157051603.1|2722258_2723065_-|lantibiotic-ABC-transporter-permease	gnl|CDD|163445	TIGR03733, lanti_perm_MutG, lantibiotic protection ABC transporter permease subunit, MutG family. Model TIGR03731 represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family is largely restricted to gallidermin-family lantibiotic cassettes, but also include orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes. In most species, this subunit is paralogous to an adjacent gene modeled separate by TIGR03732, while in some species only one subunit is found.	1.4748e-17
NZ_CP012069.2|WP_172674532.1|2706303_2707560_-|serine-hydroxymethyltransferase	gnl|CDD|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0
NZ_CP012069.2|WP_050341644.1|2728291_2728870_+|biotin-transporter-BioY	gnl|CDD|376871	pfam02632, BioY, BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes.	6.56021e-29
NZ_CP012069.2|WP_050341621.1|2709917_2711048_-|GTP-binding-protein	gnl|CDD|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	6.37856e-84
NZ_CP012069.2|WP_050341632.1|2721000_2721663_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.5814e-67
NZ_CP012069.2|WP_050341617.1|2707642_2708122_-|ribose-5-phosphate-isomerase-B	gnl|CDD|376799	pfam02502, LacAB_rpiB, Ribose/Galactose Isomerase. This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).	1.1109e-68
NZ_CP012069.2|WP_050341638.1|2723954_2724668_-|lantibiotic-protection-ABC-transporter-ATP-binding-protein	gnl|CDD|163452	TIGR03740, galliderm_ABC, gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit. Model TIGR03731 represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family describes the ATP-binding subunit of a gallidermin/epidermin class lantibiotic protection transporter. It is largely restricted to gallidermin-family lantibiotic biosynthesis and export cassettes, but also occurs in orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes.	3.99075e-126
NZ_CP012069.2|WP_050341642.1|2725327_2727967_+|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP012069.2|WP_050341623.1|2711121_2712573_-|APC-family-permease	gnl|CDD|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	3.76772e-28

Protein sequences

>NZ_CP012069.2|WP_050341628.1|2715309_2715765_-|RNA-polymerase-sigma-factor
MDVEAIYLRHVDTVYRVCYSFMGNAADSEDATQSTFVKLMKARPTFTNEEHEKAWLIRVASNHCKDVLKSSARKGVPLESVAEPAADERGPDLALDAVLALDSKYKDVVYLHYYEGYSAADIARMLGKPSSTVRTHLREARAILRKALGGQ
>NZ_CP012069.2|WP_050341626.1|2714633_2715308_-|hypothetical-protein
MDERRIREAFERMTPSEEAKERMLKNILAHSEAQGVDRPARGVSRASRGAPVTAPRRARLRFARRIAIGAAACLALIVGVGMLTRPHAAMDAARTNDALTSSAPSKTSDNMSGESRAGDSSAAKTNGMAASEEQGQASEASGVTHFPPSIEFEGRSYQRSDEALSRDDVESVREPLAEINRPSTAPGAPSVLLVYSLVGSDKDEAVGVSDPDRERFCRYTVQAS
>NZ_CP012069.2|WP_050341625.1|2712782_2714426_-|VWA-domain-containing-protein
MKKIASILVRSALASCLLCLALGGCAPAAPEQDSSLAGDSRTDATPTLSHQPKSLDSSDGANTEGLTSSSIGTPYEEPPVPYNTEEYAAMRENGFLSVAANPFSTFSADVDTASYCNLRRMLSSGTKLNDIPKGAVRIEEMLNYFRYDYRAPKDAEPFGVTPCISTCPWNPDTKLLVLGLSTEPKEYAQMHGNNLVFLIDSSGSMEDPEKMPLLKESMGELVANLNDDDTVSIVTYAGSERVVLEGAKARERERILQAVRELDANGSTNGQAGLAKAYELARAHFIEGGNNRIILASDGDLNVGITSQSELSDYVSQQRKSGVYLSVLGFGQGNYKDTKMESIADDGNGNYSYIDSIQEAKRVFGEDLCATMRTVADDVKLQVEFNPAYVKGYRLIGYENRSLNAEDFKNDKVDAGEVGSGHAVTVAYEIVTADSPMQLPEIDSKYGGGERKGEKNGEWMTLSVRYKNPGENDSKQLSYGIGEADVTDQPSDNWKFASAVIEFGMVATKSEHAGTASFDGAIALMDQMGALDDRQREFKKLVSIASL
>NZ_CP012069.2|WP_050341623.1|2711121_2712573_-|APC-family-permease
MAGSAAPTSGMKKELTLFNFFTIGFGAIIGTGWVLLVGDWMVLGGGPIPAMIAFAIGALFLVPIGMCFGELTAAIPISGGIIEYVERTFGRKLGFLTGWMLLLGNAPLCPWEAIAISKLLTDRFAEFPVLAWLRSVKLYTILGADVYLWPTLIALAFAVLVIVLNFRGASAAAKLSSFLTKALLTGMILAMIISFMGGDNLAKAMPPFSQVIGAAGGKSTEATSLLGGVLAVLVMTPFFYAGFDTIPQQAEEASENLDWKKFGLVPAIALLASGVFYLICIFAFGTIVNWHDFVMKPVPALAVLEQINIFFYIAMLIIATLGPLGPMNAFFGASTRLMLALGRKEMLPKSFAQIDPTSGTPKQANIVMGALTLIGPFLGGNMLLPLTAVASLGFIFACTMAGFACFKLRKTEPDLPRPYVVNGGKGGIIAAIVAGLIIVGLMVIPFSPAALKPVEWAITITWIVIGFVIFFACGGAKVAARKP
>NZ_CP012069.2|WP_050341621.1|2709917_2711048_-|GTP-binding-protein
MTENKRVKIILITGYLGAGKTTILNHILSNTEGVRAAVIVNDIGEINVDAALIKDGGYAREGDVIPLTNGCLCCTLSNDLSLQLGDLADTGKFDYIIIEASGICEPIPITYTISAFCNQSSHSDKHARLDLDNIVAVVDCARMYDEFDGGRALLGSNVSEDDIESLLIQQIEFCSTLVLNKVDLVTPEQLQELRALVRGLQRDAVIVEAAHGNIPIAELVDTGRFDFDRAYRSAAWMDAMEHPEEHEDPETLEYGISTFVYHRRRPFDANAFDDFVHSWPCSVIRAKGTVWIRQDPDMDYVFEQAGRQVRLYENGLFSDSFPEEEKRRLLAEQPELLRDWDPVCGDRRIRLCFIGRGMDRTAIETGLDACLREWKS
>NZ_CP012069.2|WP_050341619.1|2708382_2709630_-|amidohydrolase-family-protein
MGKYAFAGGQLVDGTGAAPINDSLVLVEDDKLTYAGRRTEIPEGFELRDVSGRTVMPGLVDTHLHFSGNLTDNDNDWVIESVAQKQACAVKQAYDALTHGLTTVVEIGRNGIAIRDLVNMGVMKGPRIFATGLGFCRVAGHGDSHHLPLQISKDSHPWGYQADGPWELRRAIRMRLRENPDAIKIWATGGGIWRWDSDRLQLFSTEEIQAIAEECAMVHIPLYAHSYNNFDAAYDCVRFGCTQMIHGFELDERTMNLMAEKGTFFTPTIGFLPTWYSTYPPEWTPELDAFPGETVVEKGLARTYANLRRAYELGITVTIGSDSFSFVTPYGYVSIDEMYDFVDKVGIPILDAIKAATSNGAKMLGKEDEFGSLEAGKSADLLVVKGDVARDIHALTPDAMEVIMKGGDIVIKGAL
>NZ_CP012069.2|WP_050341617.1|2707642_2708122_-|ribose-5-phosphate-isomerase-B
MRVAIASDHGGFDQKVALARYIQSLGHEVADLGTTTGKRCDYPDYADKVARLVASGGAERGVLICGTGIGMALAADKVPGIRAANIQTPQFARLFREHNDGNVLCLSGRFTPLELNEEIVRVFLTQQCAGGRHATRVKKIMREDDSGFKGVGKSFEQEG
>NZ_CP012069.2|WP_172674532.1|2706303_2707560_-|serine-hydroxymethyltransferase
MEQLRVEDSEVSGLIEEELGRQRDSIELIASENFVSLVVMEAVGSPLTNKYAEGLPGKRYYGGCWAVDKMEDLARERAKRLFGAAFANVQPHSGAQANYAAETAFARPGDTVIGMDLSNGGHLTHGSPANFSGKLFDIKSYGLDPKTERIDYDDVEAKARESKPAIIIAGASAYPRTIDFERFAQIAHDSGAILMVDMAHIAGIVAAGLHPNPVPCSDVVTSTTHKTLRGTRGGLILWNNPDYTKRINSAVFPGTQGGPLEHVIAGKAVTFGEALRPEFKTYIQGVLVNAKALGRGMESRGLRLVTGGTDNHLLLVDLTGVAQGEVSGRDAERALERVGITVNKNTIPGEQRSPFVTSGIRVGSAAITTRGFSEQECERVGELIGDVVTHVHDERVFDRIEAEVKELLASHPLYPGLR
>NZ_CP012069.2|WP_050341613.1|2705591_2706233_-|uracil-phosphoribosyltransferase
MGFDTSRLTIIDHPLVQHKLHILRDRDTPTKQFRELVGELAIFEGYEAMRDFPLEDIEVTTPLEKTVCKRIAGKKVAIIPILRAGLGMVDGLLSLVPSARVGHVGMYRDPTTHAPHQYYCKFPPDVESRTCLIVDPMLATGGSLTAAIQFLREAHVRDIRALTIVSAPEGVRAALDFDPDVRLYTCAVDRGLNESAYILPGLGDAGDRIYGTK
>NZ_CP012069.2|WP_050341611.1|2705097_2705385_-|hypothetical-protein
MSVGVVITCGMLCGLTGCVLPARLFERTLQKSKICDVSVPDGIMAIIVSFVFMSLCVFVLYATAQEYILVFGSSTVGAFLVFWGIEAMRAMRAMR
>NZ_CP012069.2|WP_050341630.1|2717238_2718609_-|ATP-binding-protein
MFKRKCYDKLLEWKRESSGKSAVLVEGARRVGKTTLVREFAEYEYADHIYIDFSKVPKVVLDLFRNEREDVDTFLRMLQLQYVKDMPVRESVIIFDEVQRFPMAREYIKHLVADGRFDYIETGSLISIRKSVGDIVIPSEEDRLQLHPFDFDEYLWAMGAGVYVGAIREAFFERMPLPDPVHAKVMRLFDEYILVGGMPQSVEAFVESKRFSSCDRVKHSILNLYLEDIGKFGGAEARRARALFQEIPGQLSAASKRFKFASVGRGSMYDDYEPAIDWLDDAHLVNPCRMCADPSVGLRLTERASSLKLYMADTGLLATHAFADGPRALEVQRDIQFGRVSVNRGMLVENVVAQQLRTSGHALYYHTWEEPGKKDGARPRPREIDFLITQPFADAAGKLRVSPIETKSSKNYTTVSLDDFRRKYSKRVGEEVVLHTKQLSVDGNRSYLPLYMSGLS
>NZ_CP012069.2|WP_050344569.1|2719390_2720986_-|HAMP-domain-containing-histidine-kinase
MAATQDAKASPRLRLPLALVVSRYFLYLLVGIILVVGVPLAVFGGQMGAGEILPANYGETHLEEVADTLSAQPAFDATAIPSPYRYAHFDAGGALVASDMSDFQLERARVVAASPARTRVRDGGAGAAESRLYYRLPLTGGEVCVLSYDLVPQWADKGRRDTLPDPQSLLFWSVGPPLVALIAGVAVRASRMLTRMMEPLVRAAEAVGRQDLDAPVEHSNVAQVDDVLQAMDKMRVSLRRSLEAQWEVERRGREQVAALAHDLKTPLTVVRGNAELMAEDAAAGRLNKEQATCADAICEAATSMDAFVSRIVEVSRGAADTLQLEPVDPGRLAEELEEEATRLTGARGLALAPLRLPAFLEACRAMSAGDAPLPLWDSSALKRAVLNVVGNACDYTVSGLVELTFSYGEEAQGEETRGGGARGGGARAFSIAVEDDGPGLSPAALKHGLERFYRGERSRASHRTGAGGPDERGELHFGLGLSIASEIVAAHGGRLSLSNRMGGDGAILGARVTITLPDVPRTPGREWPSVN
>NZ_CP012069.2|WP_050341632.1|2721000_2721663_-|response-regulator-transcription-factor
MARILAIDDDEAITDLLSRALVRDGHVVEVVNDPAPVLGLDLSRYDLVLCDVMMPQMDGFELVGRIRCLVDAPILFLTAKVAEEDAVHGLGLGADDYIRKPFGIAELRAKVAAHLRREGRAHTRVLALGDVRLDLGARELFVGGEVVSLTPTEYAVCELLARHRGKVFSRAQIRESALGWASDVGDDTVSMHVSNARAKLRRAGADPIETVWGTGYKWRA
>NZ_CP012069.2|WP_050341634.1|2721822_2722245_-|hypothetical-protein
MMEGTQRRRRVLLTLAVATMLVVSSLQGCTGCAGAGTVAKSVFDSLLPIPSQTVWARCPTPGSHSDSYRDASGSCTNYVYDVEAATGDGTRVTVSIILFGREASGKGWLKIDAKGSSGRHYDSVDASEVPQAARDALGGG
>NZ_CP012069.2|WP_157051603.1|2722258_2723065_-|lantibiotic-ABC-transporter-permease
MTLPHALRAEALRLHHSPLVPLHLACALAAGMACGAYFAYAPWDASMGADAFVQFLGAMMPLMVGIICGLDADGEGEATGLSGLLSVPSRYRALAARLFALWLMGAAALALAMVVFAVPFVLAGRQALGPDARALAALGLSLGSAPIYLILYAIALRWGRNSAISAGAAGLMLAFFSLGGLAHGLMTGELTAAGANAFSYLPTSWAARLGSLPVELSIAAGPAGSAAATTRVASAIGSAVGLCASVTFLLLGAMAAWISRFEPARRGE
>NZ_CP012069.2|WP_050344570.1|2723127_2723925_-|bacteriocin-ABC-transporter-permease
MARTGSEDTLAQGSFVRALRAEALKSRHGAPVRLAIVLALPFPLLAAFVALSVPQFGLSYSPWNYWYALLMPVSITLIAATVANADARLGNHTLLSSGVPLHLAWGAKVAWCLALLLLSNLVVFAVYAVMSLVVPQGAASMSAMLAVALALTVMGSWMIPATHLLTMRVGMLAGVFVPLAVQLALSLGWSVVPFWPACPPAATIVLPTAFLPVLPSGEPASPGMALVESISQGPDVALALIVAAVLTAALTAAGAVWLDRSEELR
>NZ_CP012069.2|WP_050341638.1|2723954_2724668_-|lantibiotic-protection-ABC-transporter-ATP-binding-protein
MARCVLETRGLSKRFGRGGSAQMAVDHVSLHVEEGKVYGLLGPNGAGKSTTLKMVTGVLHPSEGQMLFEGRPWRRDDLYRIGSLVEQPPLYQNLTARENLRVRTTLLGLPEERIDEVLGAVGLTDTGTKRAGRFSMGMRQRLGIALALLVHPRLLILDEPTNGLDPIGIEDLRGLIRSFPKQGITVLLSSHILGEVQHTADAVGIIVGGRLAYEDALHKGEDLEALFMNVCRKEGRR
>NZ_CP012069.2|WP_050341640.1|2724916_2725240_+|metal-sensing-transcriptional-repressor
MGTAAGPHPDRTGPRTKHTPRPNQLKRDVTRRLNRVIGQLNGIKGMVEQDRYCKDVLTQLAAAESAVQAISRLLLKEHLETCVVEQIQEGNIEVVDEVMDLLKKFGA
>NZ_CP012069.2|WP_050341642.1|2725327_2727967_+|heavy-metal-translocating-P-type-ATPase
MPSETPARETFDITGMTCAACQARVQKVAGETKGVTNASVNLLKNSMELTYDGDPATIAAVVKAIDRAGYGAEPRSTATSAAKAGRTTTTLVNPKAGAQRAIKAKRDQLVWSIVFGVPLFYLAMGPMLLWPELPGLAGMEGMMASAVTQLLLATCVLFVNREYFVRGFTSLVNLAPNMDSLIAIGSTASYAYSLVGIYQMALSLGVADLQAAHHAMMHNLYFDSAGTILVLITLGKYFEARAKGKTTSAISALMDLAPKTATVVREGQEIQVPTEDVRVGERVIVRAGESVPVDGRVVEGSASIDESAITGEPIPVEKGVGDAVTGATVSQRGWIAMRATAVGDDTTLANIIRLVDEATSSKAPIERMADRIAGVFVPTVIGIAAVTFVAWIALFTPGNFSVAFNHAVVVLVISCPCALGLATPTAIMVGTERGAKFGILIKSAEALETACKLDTVVLDKTGTITEGRPRVTDVVPGSEVEESELFRVAAALERRSEHPLAEAICAHVDERYPSADGGVAITDFEQIAGGGLRATVDGRLALAGNARLMEAEGISLGTLDAHADAVATQAKTALFFARDGRALGMVAVADTVKPTSQDAIARLRQLGIRTVMLTGDQERTARAVANQVGVDEVIAGVLPDQKDRLVHDLQRKGHRVAMVGDGINDAPALARADVGIAIGAGTDVAIESADVVLMHSDPADVATAIELSRATMRDIRQNLFWALFYNSICIPVAMGVLSPWGISLNPMMGAAAMGFSSVFVVTNALRLFGWEPSGAGHRARAVEVTPAKDEGTTDNASGTAEAQEKGSDSMAVRTLSIEGMMCEHCVAHVTEALKGVRGVKNVHVSLEDKSATLDAGPLVSNKRLEKAVEDAGYKVTSIA
>NZ_CP012069.2|WP_050341644.1|2728291_2728870_+|biotin-transporter-BioY
MSDKIGGITVQKTTTVPASIGRIAIATAALAICANVQVPLQPVPFTLQILALGLIVATLNTKEALSSTLAYLVIGALGAPVFAGAMGGLTRLVGPTGGFILGFVPAAGVGSWLCARLARTRLPQATSTFFAIVAAITIAYLFGWAQLMVVRQLSPAAAFAAGIAPFAVMDLLKAVIATSVVSAGRIALRARK

Crispr_ID: NZ_CP012069_31

• CRISPR_ID: NZ_CP012069_31
• CRISPR_location: 2754111-2754358
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP012069_31

Consensus_repeat	Method
TTTGATAGTGCCCCGCAGGCTGGCGGGTGGTTGCT	PILER-CR
TTTGATAGTGCCCCGCAGGCTGGCGGG	CRISPRCasFinder

spacers of NZ_CP012069_31

>31.1|2754146|61|NZ_CP012069|PILER-CR
TTGATAGTGCCCCGCAGGCTGGCGGGCGGTTTCCCGGACGCATTTGCCCAGTTGAGCCACT
>31.2|2754242|37|NZ_CP012069|PILER-CR
CCCCGCCTCCCGGCCGGCAGGACAGGCAGGTGGTTGC
>31.3|2754225|45|NZ_CP012069|CRISPRCasFinder
TGGTTGCTCCCCGCCTCCCGGCCGGCAGGACAGGCAGGTGGTTGC
>31.4|2754297|35|NZ_CP012069|CRISPRCasFinder
TGGTTTCCCGGACGCATTTGCCCAGTTGAGCCACT

CRISPR arrays and Neighbor proteins around NZ_CP012069_31

CRISPR arrays

The CRISPR arrays of NZ_CP012069_31

>merge|NZ_CP012069|31|2754111-2754358|PILER-CR,CRISPRCasFinder
GCCCCGCAGTCTGGCGGGTGGTTGCTTTGATAGTGCCCCGCAGGCTGGCGGGCGGTTTCCCGGACGCATTTGCCCAGTTGAGCCACTTTTGATAGTGTCCCGCAGGCTGGCGGGTGGTTGCTCCCCGCCTCCCGGCCGGCAGGACAGGCAGGTGGTTGCTTTGATAGTGCCCCGCAGGCTGGCGGGTGGTTTCCCGGACGCATTTGCCCAGTTGAGCCACTTCTGACAGTGCCCCGCAGCCTGGCGGG

>NZ_CP012069|31|5|2754111-2754301|PILER-CR
GCCCCGCAGTCTGGCGGGTGGTTGCTTTGATAGTG	CCCCGCAGGCTGGCGGGCGGTTTCCCGGACGCATTTGCCCAGTTGAGCCACTTTTGATAGT
GTCCCGCAGGCTGGCGGGTGGTTGCTCCCCGCCTC	CCGGCCGGCAGGACAGGCAGGTGGTTGCTTTGATAGT
GCCCCGCAGGCTGGCGGGTGGTT

>NZ_CP012069|31|28|2754198-2754358|CRISPRCasFinder
TTTGATAGTGTCCCGCAGGCTGGCGGG	TGGTTGCTCCCCGCCTCCCGGCCGGCAGGACAGGCAGGTGGTTGC
TTTGATAGTGCCCCGCAGGCTGGCGGG	TGGTTTCCCGGACGCATTTGCCCAGTTGAGCCACT
TCTGACAGTGCCCCGCAGCCTGGCGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050341681.1|2751836_2752430_+|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224103
NZ_CP012069.2|WP_050341691.1|2757115_2758099_-|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl|CDD|273455
NZ_CP012069.2|WP_083444113.1|2759393_2761415_-|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl|CDD|273520
NZ_CP012069.2|WP_050341687.1|2755403_2755871_-|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224870
NZ_CP012069.2|WP_050341684.1|2752621_2753941_-|O-acetylhomoserine-aminocarboxypropyltransferase/cysteine-synthase	unknown	unknown	gnl|CDD|225428
NZ_CP012069.2|WP_050341672.1|2746497_2746692_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083444005.1|2746902_2747346_+|DUF4279-domain-containing-protein	unknown	unknown	gnl|CDD|372913
NZ_CP012069.2|WP_050341677.1|2747347_2747860_+|DUF4279-domain-containing-protein	unknown	unknown	gnl|CDD|372913
NZ_CP012069.2|WP_050341694.1|2758169_2759354_-|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|180720
NZ_CP012069.2|WP_050341689.1|2755896_2756607_-|haloacid-dehalogenase-like-hydrolase	unknown	unknown	gnl|CDD|378932
NZ_CP012069.2|WP_172674533.1|2762190_2763705_-|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl|CDD|238950
NZ_CP012069.2|WP_083444004.1|2746049_2746496_+|DUF4279-domain-containing-protein	unknown	unknown	gnl|CDD|372913
NZ_CP012069.2|WP_083444007.1|2749915_2750875_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
NZ_CP012069.2|WP_083444006.1|2749193_2749919_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP012069.2|WP_050341697.1|2761606_2762155_-|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl|CDD|223707
NZ_CP012069.2|WP_050341706.1|2765923_2766445_-|DUF5104-domain-containing-protein	unknown	unknown	gnl|CDD|379921
NZ_CP012069.2|WP_050341700.1|2763771_2764992_-|peptidase-T	unknown	unknown	gnl|CDD|349887
NZ_CP012069.2|WP_050341686.1|2754463_2755372_-|adenine-glycosylase	unknown	unknown	gnl|CDD|224115
NZ_CP012069.2|WP_050341679.1|2750871_2751669_+|ABC-transporter-permease-subunit	unknown	unknown	unknown
NZ_CP012069.2|WP_050344581.1|2745344_2745719_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050341681.1|2751836_2752430_+|NAD(P)H-dependent-oxidoreductase	gnl|CDD|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	9.47935e-22
NZ_CP012069.2|WP_050341691.1|2757115_2758099_-|DNA-polymerase-III-subunit-delta	gnl|CDD|273455	TIGR01128, DNA_polymerase_III_subunit_delta, DNA polymerase III, delta subunit. DNA polymerase III delta (holA) and delta prime (holB) subunits are distinct proteins encoded by separate genes. The delta prime subunit (holB) exhibits sequence homology to the tau and gamma subunits (dnaX), but the delta subunit (holA) does not demonstrate this same homology with dnaX. The delta, delta prime, gamma, chi and psi subunits form the gamma complex subassembly of DNA polymerase III holoenzyme, which couples ATP to assemble the ring-shaped beta subunit around DNA forming a DNA sliding clamp. [DNA metabolism, DNA replication, recombination, and repair].	8.41958e-33
NZ_CP012069.2|WP_083444113.1|2759393_2761415_-|ATP-dependent-zinc-metalloprotease-FtsH	gnl|CDD|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP012069.2|WP_050341687.1|2755403_2755871_-|Rrf2-family-transcriptional-regulator	gnl|CDD|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	5.31489e-30
NZ_CP012069.2|WP_050341684.1|2752621_2753941_-|O-acetylhomoserine-aminocarboxypropyltransferase/cysteine-synthase	gnl|CDD|225428	COG2873, MET17, O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism].	0
NZ_CP012069.2|WP_050341694.1|2758169_2759354_-|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|180720	PRK06836, PRK06836, pyridoxal phosphate-dependent aminotransferase.	0
NZ_CP012069.2|WP_083444005.1|2746902_2747346_+|DUF4279-domain-containing-protein	gnl|CDD|372913	pfam14106, DUF4279, Domain of unknown function (DUF4279). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	1.67605e-13
NZ_CP012069.2|WP_050341677.1|2747347_2747860_+|DUF4279-domain-containing-protein	gnl|CDD|372913	pfam14106, DUF4279, Domain of unknown function (DUF4279). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	9.65128e-06
NZ_CP012069.2|WP_050341689.1|2755896_2756607_-|haloacid-dehalogenase-like-hydrolase	gnl|CDD|378932	pfam12710, HAD, haloacid dehalogenase-like hydrolase.	4.302e-22
NZ_CP012069.2|WP_172674533.1|2762190_2763705_-|tRNA-lysidine(34)-synthetase-TilS	gnl|CDD|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	1.81126e-58
NZ_CP012069.2|WP_083444004.1|2746049_2746496_+|DUF4279-domain-containing-protein	gnl|CDD|372913	pfam14106, DUF4279, Domain of unknown function (DUF4279). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	7.10609e-14
NZ_CP012069.2|WP_083444007.1|2749915_2750875_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.22142e-74
NZ_CP012069.2|WP_083444006.1|2749193_2749919_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.17359e-12
NZ_CP012069.2|WP_050341697.1|2761606_2762155_-|hypoxanthine-phosphoribosyltransferase	gnl|CDD|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	1.2193e-78
NZ_CP012069.2|WP_050341706.1|2765923_2766445_-|DUF5104-domain-containing-protein	gnl|CDD|379921	pfam17117, DUF5104, Domain of unknown function (DUF5104). This is a family of gut microbes of unknown function.	2.74297e-06
NZ_CP012069.2|WP_050341700.1|2763771_2764992_-|peptidase-T	gnl|CDD|349887	cd03892, M20_peptT, M20 Peptidase T specifically cleaves tripeptides. Peptidase M20 family, Peptidase T (peptT; tripeptide aminopeptidase; tripeptidase) subfamily. PepT acts only on tripeptide substrates, and is thus called a tripeptidase. It catalyzes the release of N-terminal amino acids with hydrophobic side chains from tripeptides with high specificity; dipeptides, tetrapeptides or tripeptides with the N-terminus blocked are not cleaved. Tripeptidases are known to function at the final stage of proteolysis in lactococcal bacteria and release amino acids from tripeptides produced during the digestion of milk proteins such as casein.	0
NZ_CP012069.2|WP_050341686.1|2754463_2755372_-|adenine-glycosylase	gnl|CDD|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	2.01806e-54

Protein sequences

>NZ_CP012069.2|WP_050341684.1|2752621_2753941_-|O-acetylhomoserine-aminocarboxypropyltransferase/cysteine-synthase
MAFALDPSFAQDPEKHFDTLQVHAGYAPDPTTGSAALPIYASAAFQFEDAADGAAKFALARPGNVYGRLTNTTADAVAARVAAVEGAAGAVAVASGHAAEILAITNIAGAGDHVVASDSLYGGTWNILLHTLADLGIETTFVQNNDIDAFVAATRKNTKLWYVETIGNPLVDVANIPALVEAARSLSEPVPVFVDNTFATPYLYRPTQDGAAVVLESLTKWIGGHGVALGGAVVDAGTYDWKAQADKFPTIAKPDPSYHGAVFADAAPAAPFSTRVLANKLRDFGPTLSPYAAQLIGIGLETLSLRVERHCANALAVAQFLRDHPKVKWVRYPGLADDPSHDLASRLLRHGFGGVLVFGVAGGREAGLKVVDNVRLFTHLANVGDAKSLIIHPTSTTHSQLSAEQLEAAHLSEDLVRLSVGIEDVDDLIADLDQALAKL
>NZ_CP012069.2|WP_050341681.1|2751836_2752430_+|NAD(P)H-dependent-oxidoreductase
MSEKKLLFVNACVNKSTSRTLRIASRLLELLKESYVIEELDLEHLDIHPLDSQRLNERLALLARGELLDPSFILARQFANANCVVVAAPYWDFGFPAMLKVYIENISVTGISYRYGERGQTVGLCKAERLYYVTTRGGLVTDEDDLGYRTLEGMGHIYGIKDIRCMSARGLDIVTVDADAEVSRAIDEKVSAPGALT
>NZ_CP012069.2|WP_050341679.1|2750871_2751669_+|ABC-transporter-permease-subunit
MSLTLYARELRRGVLPFFVIAAILTMYIVSVVYMYDPKITENLSLIMSTMPDAFAAFGMSHAATTMTGFMLNYLYGFLFTWVPLLLIMMTVNRMVVRPIDRGSLACVLSSPVSRPRIAITLAAVMLTVLASMLALIIVAQLACAEALFPGELNRAELLRASVGLFCLWTFMAGLCFASACTFRDARAALWVGGGACLLMFLAKMAAQVGKGLEFLQDANPVTLFDPYGLAAMSGDAALDAAILAAVGLALLAVGAAVFCRRDFDV
>NZ_CP012069.2|WP_083444007.1|2749915_2750875_+|ABC-transporter-ATP-binding-protein
MTGKRVIMAQGLTKDYGQGRGVFDLSFAVRQGEVFGFLGSNGAGKTVTMRHLMGFIRPQSGSAHIFGLDCFSERAVIQRRLGHLPGEMATPEDMSGLAFLEFMARLRKLDDRTRMNELMERFELDPRPKIRKMSKGTKQKVGLVCAFMSRPDVLLLDEPTSGFDPLMQGRFVELVLEERDRGATILLSSHMFEEVERSCDRVAFIRAGHLVGVERMADVRASRRHAFRVSFSSKEERERYLQTCARSGARAHALDECGVELWADGGVDALIKGLANFHVVGLTSREQTLEELFLHFYGDGPSEDDPVEKQPSTTREDIL
>NZ_CP012069.2|WP_083444006.1|2749193_2749919_+|TetR/AcrR-family-transcriptional-regulator
MSEPDVLTLCQKQDAFGRLPKERREAIAQASIETFGRNDYKGASTDDIARAAGISKGLLFFYCKSKRQLYLHTLEYLYDKAIEIVADDDFWEIDDFFELMIYAAQRKMAMMRRFPWALSFCIRAFYPEHRDIKDNVSNWTWRQTDVVFKRFFANVDWGKFRDGVDARHVFDMLIWLTDGWVHQRRATHGVVDVDVLMREFLTWCDMLRAWAYKPECLGEARGGPRTVAGAHGGTDGEETSS
>NZ_CP012069.2|WP_050341677.1|2747347_2747860_+|DUF4279-domain-containing-protein
MEPQVETTLCVTGGRLDFEAIGDALGLEPTSTCRAGELPAAVARAGLACDAWQHTIAREECRWPPTHIDRLQDAIGEGAARLRALLSEHVAKVAVVIDIQMEAMCNPFLGLTARNVAFLNSVDAELRMRLEIHEPDNPDDYDDPEGVIQDVRRHQELGDALWAWRRAGNA
>NZ_CP012069.2|WP_083444005.1|2746902_2747346_+|DUF4279-domain-containing-protein
MRPRVRASFGITGNDLDLDAITESLGVAPTSTRLKEDFPEVSQRMGLAADTWGYTIPRAECASVSERIGALEAVFGDKAGQISAVRERYAANVSVGLSLHAVIGDEPDLTLTRGDLAFLGSMGAELGIDPYLYYPDEGDLPPVGEGA
>NZ_CP012069.2|WP_050341672.1|2746497_2746692_+|hypothetical-protein
MRPRVETTLCVTGGRLDFGAIGAALGIGPTSACRAGELPAAVARAGLACSDEYHRASLAAQGWA
>NZ_CP012069.2|WP_083444004.1|2746049_2746496_+|DUF4279-domain-containing-protein
MRPRVRASFGITGDDLDLGAITESLGIAPTEVYRKEDARAVIKEMGLAADTWGYTIPRAECTSVSERIGALEAVFGDRTGQISAVRERYAANVSVELSLHAVIGDEPDLTLTRGDLAFLGALGAEFGIDPYPYYPDETDDLPPVGEGA
>NZ_CP012069.2|WP_050344581.1|2745344_2745719_-|hypothetical-protein
MAFGFKLKHVKTKEPFADTKALYERIKDERFYAGKPELVKNGFADVIVFPALDSQNQVWVTMFGKHRIQVQKNQEAGVTNAVVNEAINTVTSGLFGLKSIIGKNAKEIEIQVEKTAKELEALGL
>NZ_CP012069.2|WP_050341686.1|2754463_2755372_-|adenine-glycosylase
MPNGSALHEEWIDSLGPTLASFRDLVLERGRNCYRDLPWRQTHDPYAIWVSEVMLQQTQTSRIDGRWQRWLERFPTIEALAGAERADVLAEWQGLGYNRRALQLWQAADQLVRTDGVLPYELDALVGLPGIGPATAAGIRAFAFDLPGIYLETNVRSVFLHEFFPEVRGVRDGELAPLVAQTCPPDASDPADDPRNWYYALLDYGAHLKRTLPNPSRRSATHARQSQFEGSHRQKRSSLVRLLLAHRACGEAHVSCDTLAEELSGVERQAGREDLSCSQVETLLEELREEGFCHQEGGLWYV
>NZ_CP012069.2|WP_050341687.1|2755403_2755871_-|Rrf2-family-transcriptional-regulator
MDLSRKTDYALRMVAELVEHEGQIVSVRVAAERRGVPYSFARSIQRDLAHAGIIESTRGSRGGMRLLMDPKKTTVRSVVEALQGPIRISACDHSGEDGGPCPFMPDCHFNPVWCEAENILRDYFDAMTIYDVVVERKHPALSKGNTFELVKPHSE
>NZ_CP012069.2|WP_050341689.1|2755896_2756607_-|haloacid-dehalogenase-like-hydrolase
MGKNETSGDGVACDKRTRIAAFDYDGTIISGQSGALFASYLFAHGYLRLARALRLGWWGVRYVLHLPYRQGEAREQVFSALSERTPEEVHRIMMDFHDEVLLRRYRQEAIREIGKRKREGCTILLVSATFKDIAQRAVRVTGADDFVATGMELDANGNYTGNVDGVVIAGPEKTKAVIGWANEHIGTDAWTIAYSYADHHSDADLLAASEKAYAVTPGKALRLKAKRQHWQVLNWG
>NZ_CP012069.2|WP_050341691.1|2757115_2758099_-|DNA-polymerase-III-subunit-delta
MGAGAGSGLLSAYLVVGTDELKSRAAQTRLKGRLAQGYEAFNLDERVANKELEPGELLASLNTLPVGGGLRLVLVVEAEHLAKPTSEAIIDYLKDPNPDCVLCLVAATLAKSTRLYKAVAAVGPRAVIDCAPKKGKRLVPVIQKMAQAQRMRMCGEAAEELLSRVGESTIMLESQVRSLAALKGAAGEITLQDVRNHIARTAEVKPWDFLDAVSAREFARALELYGLMRKPSQIALVSLLEGRIRELACARSLELRGEALQLAKTLGRPPWAVRGHLGWSRRFGSGELERSLVACARCECELKSGRDVETSFLGLISAICGVSSDMG
>NZ_CP012069.2|WP_050341694.1|2758169_2759354_-|pyridoxal-phosphate-dependent-aminotransferase
MSINQKSYDYGASRSSIREIAAYGAARKAQIGVQNVFDFSLGNPSVPAPDSVRESIERSLSLPATQLHGYTPAAGLPIARKAVADSLNRRFNTSYDPGDVYMTCGAAASLSITLNAIVNPGDEVIVIAPYFPEYRVWIEAAGASCVEVLADTTTFQIDSDSLHSALSERTKAIIINSPNNPVGSIYSRERLKAAATVIRECERELGTSIYLLSDEPYREISYGAEVPWVPSIYDRTIVCYSYSKSLSLPGERIGWILVPNTNPDHESLLAAVAGAGRKLGFVCAPALFQRVVADCVDVPCDVGAYERNRAILTEGLLRLGYEFIEPQGAFYLWLKSLEPDSVSFFEKAKAFELLPVPSDSFGCAGWVRVSYCVGHKTIVDSMPAWERLAAAYRP
>NZ_CP012069.2|WP_083444113.1|2759393_2761415_-|ATP-dependent-zinc-metalloprotease-FtsH
MGAALLGFIFVIVLAAHLFSSPGRGALGGGARVDELATNEFVSAVRDGRVSSVTYKATDGSLSGSYWPSKSDKDEGNGPVDFTSSYVGNDSLQELMAKHPDTTFTVETSDGFGASLIATVLPTLLIAGMLVYFVRQVQAQNGRTMSFGRATRARTSDKSRPKVKFEDVAGVDEAVEELKEVRDFLREPERYQKMGAKIPRGVLLVGPPGTGKTLLAKAVAGEASVPFFSISGSDFVEMFVGVGASRVRDLFKQAKDSAPSIIFIDELDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGFDENSSAILIAATNRPDVLDPALLRPGRFDRQVMVDRPDVKGRERILAVHAENKPKDDDIDYERIAKLTPGFTGAELANLMNEAALLAARRHKDKISMDEVEESMERIIAGPEKKGRVMTEKERLTIAFHESGHALVGHILENSDPVHKISIISRGRALGYTLQLPEEDHFLETRDGMLDEIAVLLGGRTAEELFCEDITTGASNDLERATKVARKMVTQYGMSEDLGTQVYGEAQHEVFLGRDYANHNDYAAETAKRIDDEVERIMREAHLRARRVLESRRNQMATMARVLLDRETVEGEVVDALLDDRWAEFVETHPTERVDLNHDGIDDSVVVPEDDKVTAGLVAAERARAARQTAREREGGLPKGKVAGEG
>NZ_CP012069.2|WP_050341697.1|2761606_2762155_-|hypoxanthine-phosphoribosyltransferase
MEGLHPDIQSIILGEDDIRKVIERLGREVSRDYVGKSPLIVAVLRGAFVFTADLMRAITVPCSVDFMAVSSYGDGVKSSGVVRIVKDLDTKIEGRHVLIAEDILDSGLTLSYLIDLLQARRPASVHVATFAVKDIEGKVPAIDPRYVGVHVPNEFIVGYGLDYAERYRNLPYIGILKPEVYK
>NZ_CP012069.2|WP_172674533.1|2762190_2763705_-|tRNA-lysidine(34)-synthetase-TilS
MTSVMRRYATGEQRLGRPSSAAAGEMRAPVVLMVSGGADSTALLLLAVTSKLDIDDGRGLAHMARERLHVLHVNHQLRGEDSEGDEEFVRELARRHGIPCTVRRVDVAARARDASFPDANVESVGRDVRYAAARELANQLSAEFGTPRSAARILTAHTADDRAETFLMNAMRGSGVAGLSSIPRRRNRIVRPLLDRTHEDLCDFLRMRGIVWREDTTNADTRYLRSFVRHRVMPPIKERSPRVVSSLSTTCDILSEEDSYLTRVATRAFRDLVRRRSKGMLALDAAKLGACEVAIARRVVRMAMLELAPQARLEARHVDATLSLVAATHGSISTPMGCDVRVEYGLLFMRAHSVERSGEPFWLHVPGDHTLLDGSRLMARLADVPMGSDPVGMARSHGMEWEGLSVMLDAGACGVSRAPGSCLWVDGPVAGDLLCPLGMHGQSKKLSDLLNEARIPARDRASVPIVRTGPRGVIVWVAGVRADERARCTQSTRLLLELSLVRPD
>NZ_CP012069.2|WP_050341700.1|2763771_2764992_-|peptidase-T
MKAYERLLKYAVMRTPSDGKSAATPTTKQQFDLARLLVAELKELGVDDVTLSDECFVYAKLPATPGLEDKRRLGLIAHMDTVSQYCDHDIRPQLTPNYDGKDLSLGTSGRTLTVRDFPHLPSLRGRTLITSDGTTILGVDDKAGIAEIMTTLEIIRDKRIAHGPLRIAFTPDEETGTGASHFDVEHFDAEVAYTLDGDTEGEIQYQNFNACEATFEFRGVSVHPGSAKDVMVNAVLLALEANNMLPGLETPRYTEGYEGFYHLLSIHGDEARATSSYIVRDHRECSFEVRKATLRHIEKVMNELWGAGTVTLTIEEEYRNMESVIEGRMYLIDYARQAAERAGLRAEVSPIRGGTDGSQLSFRGLPCPNLGTGGHGYHGPFEHTTVEGMDLATTMAVELVKVYAQN
>NZ_CP012069.2|WP_050341706.1|2765923_2766445_-|DUF5104-domain-containing-protein
MAGPVTRRRLLAAGVALATATLPGCLGHRTDREIEHDLSRRVLACLNEDDADGLEALFCEASRARPELRAEIARGMGFFEGRVDLSAGWREGGWSTVSGGGLYAEGGRVLERSVDPHVTGIVIDAGRRYKVVICYCDVGVDHPDWVGVSEIDVIATRPDRHNGEKCAIGQYVK

Crispr_ID: NZ_CP012069_32

• CRISPR_ID: NZ_CP012069_32
• CRISPR_location: 2765516-2765611
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_32

Consensus_repeat	Method
TTTCCGTGAGGCCCGACGTGCAG	CRISPRCasFinder

spacers of NZ_CP012069_32

>32.1|2765539|50|NZ_CP012069|CRISPRCasFinder
GGTGCGCTTTTCCGTGAGGTGTGCTCTGCGGGCGCGGGCCAGACTGCGCT

CRISPR arrays and Neighbor proteins around NZ_CP012069_32

CRISPR arrays

The CRISPR arrays of NZ_CP012069_32

>merge|NZ_CP012069|32|2765516-2765611|CRISPRCasFinder
TTTCCGTGAGGCCCGACGTGCAGGGTGCGCTTTTCCGTGAGGTGTGCTCTGCGGGCGCGGGCCAGACTGCGCTTTTCCGTGAGGCCCAACGTGCAG

>NZ_CP012069|32|29|2765516-2765611|CRISPRCasFinder
TTTCCGTGAGGCCCGACGTGCAG	GGTGCGCTTTTCCGTGAGGTGTGCTCTGCGGGCGCGGGCCAGACTGCGCT
TTTCCGTGAGGCCCAACGTGCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050341714.1|2770667_2771540_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051532.1|2773441_2774893_+|hypothetical-protein	unknown	unknown	gnl|CDD|340394
NZ_CP012069.2|WP_050341722.1|2775494_2777708_-|PASTA-domain-containing-protein	unknown	unknown	gnl|CDD|225372
NZ_CP012069.2|WP_050341691.1|2757115_2758099_-|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl|CDD|273455
NZ_CP012069.2|WP_083444113.1|2759393_2761415_-|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl|CDD|273520
NZ_CP012069.2|WP_050341687.1|2755403_2755871_-|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224870
NZ_CP012069.2|WP_050341684.1|2752621_2753941_-|O-acetylhomoserine-aminocarboxypropyltransferase/cysteine-synthase	unknown	unknown	gnl|CDD|225428
NZ_CP012069.2|WP_050341694.1|2758169_2759354_-|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|180720
NZ_CP012069.2|WP_050341720.1|2775163_2775469_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341689.1|2755896_2756607_-|haloacid-dehalogenase-like-hydrolase	unknown	unknown	gnl|CDD|378932
NZ_CP012069.2|WP_050341709.1|2767578_2768004_-|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl|CDD|223149
NZ_CP012069.2|WP_050341715.1|2771675_2773439_+|hypothetical-protein	unknown	unknown	gnl|CDD|379902
NZ_CP012069.2|WP_172674533.1|2762190_2763705_-|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl|CDD|238950
NZ_CP012069.2|WP_050341712.1|2769747_2770365_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP012069.2|WP_157051531.1|2768607_2769066_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341697.1|2761606_2762155_-|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl|CDD|223707
NZ_CP012069.2|WP_050341706.1|2765923_2766445_-|DUF5104-domain-containing-protein	unknown	unknown	gnl|CDD|379921
NZ_CP012069.2|WP_050341700.1|2763771_2764992_-|peptidase-T	unknown	unknown	gnl|CDD|349887
NZ_CP012069.2|WP_050341686.1|2754463_2755372_-|adenine-glycosylase	unknown	unknown	gnl|CDD|224115
NZ_CP012069.2|WP_050341708.1|2766493_2767015_-|DUF5104-domain-containing-protein	unknown	unknown	gnl|CDD|379921

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_157051532.1|2773441_2774893_+|hypothetical-protein	gnl|CDD|340394	cd16917, HATPase_UhpB-NarQ-NarX-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ. This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.	4.54351e-13
NZ_CP012069.2|WP_050341722.1|2775494_2777708_-|PASTA-domain-containing-protein	gnl|CDD|225372	COG2815, COG2815, Uncharacterized protein conserved in bacteria [Function unknown].	5.97495e-28
NZ_CP012069.2|WP_050341691.1|2757115_2758099_-|DNA-polymerase-III-subunit-delta	gnl|CDD|273455	TIGR01128, DNA_polymerase_III_subunit_delta, DNA polymerase III, delta subunit. DNA polymerase III delta (holA) and delta prime (holB) subunits are distinct proteins encoded by separate genes. The delta prime subunit (holB) exhibits sequence homology to the tau and gamma subunits (dnaX), but the delta subunit (holA) does not demonstrate this same homology with dnaX. The delta, delta prime, gamma, chi and psi subunits form the gamma complex subassembly of DNA polymerase III holoenzyme, which couples ATP to assemble the ring-shaped beta subunit around DNA forming a DNA sliding clamp. [DNA metabolism, DNA replication, recombination, and repair].	8.41958e-33
NZ_CP012069.2|WP_083444113.1|2759393_2761415_-|ATP-dependent-zinc-metalloprotease-FtsH	gnl|CDD|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP012069.2|WP_050341687.1|2755403_2755871_-|Rrf2-family-transcriptional-regulator	gnl|CDD|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	5.31489e-30
NZ_CP012069.2|WP_050341684.1|2752621_2753941_-|O-acetylhomoserine-aminocarboxypropyltransferase/cysteine-synthase	gnl|CDD|225428	COG2873, MET17, O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism].	0
NZ_CP012069.2|WP_050341694.1|2758169_2759354_-|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|180720	PRK06836, PRK06836, pyridoxal phosphate-dependent aminotransferase.	0
NZ_CP012069.2|WP_050341689.1|2755896_2756607_-|haloacid-dehalogenase-like-hydrolase	gnl|CDD|378932	pfam12710, HAD, haloacid dehalogenase-like hydrolase.	4.302e-22
NZ_CP012069.2|WP_050341709.1|2767578_2768004_-|Hsp20/alpha-crystallin-family-protein	gnl|CDD|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	6.76752e-23
NZ_CP012069.2|WP_050341715.1|2771675_2773439_+|hypothetical-protein	gnl|CDD|379902	pfam16927, HisKA_7TM, N-terminal 7TM region of histidine kinase. HisKA_7TM is an N-terminal region consisting of seven transmembrane domains found in Archaea and some bacteria. It is always found associated with histidine kinase.	1.53499e-09
NZ_CP012069.2|WP_172674533.1|2762190_2763705_-|tRNA-lysidine(34)-synthetase-TilS	gnl|CDD|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	1.81126e-58
NZ_CP012069.2|WP_050341712.1|2769747_2770365_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.09521e-43
NZ_CP012069.2|WP_050341697.1|2761606_2762155_-|hypoxanthine-phosphoribosyltransferase	gnl|CDD|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	1.2193e-78
NZ_CP012069.2|WP_050341706.1|2765923_2766445_-|DUF5104-domain-containing-protein	gnl|CDD|379921	pfam17117, DUF5104, Domain of unknown function (DUF5104). This is a family of gut microbes of unknown function.	2.74297e-06
NZ_CP012069.2|WP_050341700.1|2763771_2764992_-|peptidase-T	gnl|CDD|349887	cd03892, M20_peptT, M20 Peptidase T specifically cleaves tripeptides. Peptidase M20 family, Peptidase T (peptT; tripeptide aminopeptidase; tripeptidase) subfamily. PepT acts only on tripeptide substrates, and is thus called a tripeptidase. It catalyzes the release of N-terminal amino acids with hydrophobic side chains from tripeptides with high specificity; dipeptides, tetrapeptides or tripeptides with the N-terminus blocked are not cleaved. Tripeptidases are known to function at the final stage of proteolysis in lactococcal bacteria and release amino acids from tripeptides produced during the digestion of milk proteins such as casein.	0
NZ_CP012069.2|WP_050341686.1|2754463_2755372_-|adenine-glycosylase	gnl|CDD|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	2.01806e-54
NZ_CP012069.2|WP_050341708.1|2766493_2767015_-|DUF5104-domain-containing-protein	gnl|CDD|379921	pfam17117, DUF5104, Domain of unknown function (DUF5104). This is a family of gut microbes of unknown function.	1.59344e-10

Protein sequences

>NZ_CP012069.2|WP_050341700.1|2763771_2764992_-|peptidase-T
MKAYERLLKYAVMRTPSDGKSAATPTTKQQFDLARLLVAELKELGVDDVTLSDECFVYAKLPATPGLEDKRRLGLIAHMDTVSQYCDHDIRPQLTPNYDGKDLSLGTSGRTLTVRDFPHLPSLRGRTLITSDGTTILGVDDKAGIAEIMTTLEIIRDKRIAHGPLRIAFTPDEETGTGASHFDVEHFDAEVAYTLDGDTEGEIQYQNFNACEATFEFRGVSVHPGSAKDVMVNAVLLALEANNMLPGLETPRYTEGYEGFYHLLSIHGDEARATSSYIVRDHRECSFEVRKATLRHIEKVMNELWGAGTVTLTIEEEYRNMESVIEGRMYLIDYARQAAERAGLRAEVSPIRGGTDGSQLSFRGLPCPNLGTGGHGYHGPFEHTTVEGMDLATTMAVELVKVYAQN
>NZ_CP012069.2|WP_172674533.1|2762190_2763705_-|tRNA-lysidine(34)-synthetase-TilS
MTSVMRRYATGEQRLGRPSSAAAGEMRAPVVLMVSGGADSTALLLLAVTSKLDIDDGRGLAHMARERLHVLHVNHQLRGEDSEGDEEFVRELARRHGIPCTVRRVDVAARARDASFPDANVESVGRDVRYAAARELANQLSAEFGTPRSAARILTAHTADDRAETFLMNAMRGSGVAGLSSIPRRRNRIVRPLLDRTHEDLCDFLRMRGIVWREDTTNADTRYLRSFVRHRVMPPIKERSPRVVSSLSTTCDILSEEDSYLTRVATRAFRDLVRRRSKGMLALDAAKLGACEVAIARRVVRMAMLELAPQARLEARHVDATLSLVAATHGSISTPMGCDVRVEYGLLFMRAHSVERSGEPFWLHVPGDHTLLDGSRLMARLADVPMGSDPVGMARSHGMEWEGLSVMLDAGACGVSRAPGSCLWVDGPVAGDLLCPLGMHGQSKKLSDLLNEARIPARDRASVPIVRTGPRGVIVWVAGVRADERARCTQSTRLLLELSLVRPD
>NZ_CP012069.2|WP_050341697.1|2761606_2762155_-|hypoxanthine-phosphoribosyltransferase
MEGLHPDIQSIILGEDDIRKVIERLGREVSRDYVGKSPLIVAVLRGAFVFTADLMRAITVPCSVDFMAVSSYGDGVKSSGVVRIVKDLDTKIEGRHVLIAEDILDSGLTLSYLIDLLQARRPASVHVATFAVKDIEGKVPAIDPRYVGVHVPNEFIVGYGLDYAERYRNLPYIGILKPEVYK
>NZ_CP012069.2|WP_083444113.1|2759393_2761415_-|ATP-dependent-zinc-metalloprotease-FtsH
MGAALLGFIFVIVLAAHLFSSPGRGALGGGARVDELATNEFVSAVRDGRVSSVTYKATDGSLSGSYWPSKSDKDEGNGPVDFTSSYVGNDSLQELMAKHPDTTFTVETSDGFGASLIATVLPTLLIAGMLVYFVRQVQAQNGRTMSFGRATRARTSDKSRPKVKFEDVAGVDEAVEELKEVRDFLREPERYQKMGAKIPRGVLLVGPPGTGKTLLAKAVAGEASVPFFSISGSDFVEMFVGVGASRVRDLFKQAKDSAPSIIFIDELDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGFDENSSAILIAATNRPDVLDPALLRPGRFDRQVMVDRPDVKGRERILAVHAENKPKDDDIDYERIAKLTPGFTGAELANLMNEAALLAARRHKDKISMDEVEESMERIIAGPEKKGRVMTEKERLTIAFHESGHALVGHILENSDPVHKISIISRGRALGYTLQLPEEDHFLETRDGMLDEIAVLLGGRTAEELFCEDITTGASNDLERATKVARKMVTQYGMSEDLGTQVYGEAQHEVFLGRDYANHNDYAAETAKRIDDEVERIMREAHLRARRVLESRRNQMATMARVLLDRETVEGEVVDALLDDRWAEFVETHPTERVDLNHDGIDDSVVVPEDDKVTAGLVAAERARAARQTAREREGGLPKGKVAGEG
>NZ_CP012069.2|WP_050341694.1|2758169_2759354_-|pyridoxal-phosphate-dependent-aminotransferase
MSINQKSYDYGASRSSIREIAAYGAARKAQIGVQNVFDFSLGNPSVPAPDSVRESIERSLSLPATQLHGYTPAAGLPIARKAVADSLNRRFNTSYDPGDVYMTCGAAASLSITLNAIVNPGDEVIVIAPYFPEYRVWIEAAGASCVEVLADTTTFQIDSDSLHSALSERTKAIIINSPNNPVGSIYSRERLKAAATVIRECERELGTSIYLLSDEPYREISYGAEVPWVPSIYDRTIVCYSYSKSLSLPGERIGWILVPNTNPDHESLLAAVAGAGRKLGFVCAPALFQRVVADCVDVPCDVGAYERNRAILTEGLLRLGYEFIEPQGAFYLWLKSLEPDSVSFFEKAKAFELLPVPSDSFGCAGWVRVSYCVGHKTIVDSMPAWERLAAAYRP
>NZ_CP012069.2|WP_050341691.1|2757115_2758099_-|DNA-polymerase-III-subunit-delta
MGAGAGSGLLSAYLVVGTDELKSRAAQTRLKGRLAQGYEAFNLDERVANKELEPGELLASLNTLPVGGGLRLVLVVEAEHLAKPTSEAIIDYLKDPNPDCVLCLVAATLAKSTRLYKAVAAVGPRAVIDCAPKKGKRLVPVIQKMAQAQRMRMCGEAAEELLSRVGESTIMLESQVRSLAALKGAAGEITLQDVRNHIARTAEVKPWDFLDAVSAREFARALELYGLMRKPSQIALVSLLEGRIRELACARSLELRGEALQLAKTLGRPPWAVRGHLGWSRRFGSGELERSLVACARCECELKSGRDVETSFLGLISAICGVSSDMG
>NZ_CP012069.2|WP_050341689.1|2755896_2756607_-|haloacid-dehalogenase-like-hydrolase
MGKNETSGDGVACDKRTRIAAFDYDGTIISGQSGALFASYLFAHGYLRLARALRLGWWGVRYVLHLPYRQGEAREQVFSALSERTPEEVHRIMMDFHDEVLLRRYRQEAIREIGKRKREGCTILLVSATFKDIAQRAVRVTGADDFVATGMELDANGNYTGNVDGVVIAGPEKTKAVIGWANEHIGTDAWTIAYSYADHHSDADLLAASEKAYAVTPGKALRLKAKRQHWQVLNWG
>NZ_CP012069.2|WP_050341687.1|2755403_2755871_-|Rrf2-family-transcriptional-regulator
MDLSRKTDYALRMVAELVEHEGQIVSVRVAAERRGVPYSFARSIQRDLAHAGIIESTRGSRGGMRLLMDPKKTTVRSVVEALQGPIRISACDHSGEDGGPCPFMPDCHFNPVWCEAENILRDYFDAMTIYDVVVERKHPALSKGNTFELVKPHSE
>NZ_CP012069.2|WP_050341686.1|2754463_2755372_-|adenine-glycosylase
MPNGSALHEEWIDSLGPTLASFRDLVLERGRNCYRDLPWRQTHDPYAIWVSEVMLQQTQTSRIDGRWQRWLERFPTIEALAGAERADVLAEWQGLGYNRRALQLWQAADQLVRTDGVLPYELDALVGLPGIGPATAAGIRAFAFDLPGIYLETNVRSVFLHEFFPEVRGVRDGELAPLVAQTCPPDASDPADDPRNWYYALLDYGAHLKRTLPNPSRRSATHARQSQFEGSHRQKRSSLVRLLLAHRACGEAHVSCDTLAEELSGVERQAGREDLSCSQVETLLEELREEGFCHQEGGLWYV
>NZ_CP012069.2|WP_050341684.1|2752621_2753941_-|O-acetylhomoserine-aminocarboxypropyltransferase/cysteine-synthase
MAFALDPSFAQDPEKHFDTLQVHAGYAPDPTTGSAALPIYASAAFQFEDAADGAAKFALARPGNVYGRLTNTTADAVAARVAAVEGAAGAVAVASGHAAEILAITNIAGAGDHVVASDSLYGGTWNILLHTLADLGIETTFVQNNDIDAFVAATRKNTKLWYVETIGNPLVDVANIPALVEAARSLSEPVPVFVDNTFATPYLYRPTQDGAAVVLESLTKWIGGHGVALGGAVVDAGTYDWKAQADKFPTIAKPDPSYHGAVFADAAPAAPFSTRVLANKLRDFGPTLSPYAAQLIGIGLETLSLRVERHCANALAVAQFLRDHPKVKWVRYPGLADDPSHDLASRLLRHGFGGVLVFGVAGGREAGLKVVDNVRLFTHLANVGDAKSLIIHPTSTTHSQLSAEQLEAAHLSEDLVRLSVGIEDVDDLIADLDQALAKL
>NZ_CP012069.2|WP_050341706.1|2765923_2766445_-|DUF5104-domain-containing-protein
MAGPVTRRRLLAAGVALATATLPGCLGHRTDREIEHDLSRRVLACLNEDDADGLEALFCEASRARPELRAEIARGMGFFEGRVDLSAGWREGGWSTVSGGGLYAEGGRVLERSVDPHVTGIVIDAGRRYKVVICYCDVGVDHPDWVGVSEIDVIATRPDRHNGEKCAIGQYVK
>NZ_CP012069.2|WP_050341708.1|2766493_2767015_-|DUF5104-domain-containing-protein
MAGPITRRRLLAAGVALATATLPGCLGHRTDSEIEYDLSRRVLACLNEDDVDGLEALFCEASRARPELRAEIARGMGFFEGRVDLSAGWREGGWSTVSGGGLDVEGGRVLGRSVDPHVTGIVTDAGKRYGVRIYYCDVSVDHPDWVGVSEIDVIATRPDGEEGEKRVMGKILR
>NZ_CP012069.2|WP_050341709.1|2767578_2768004_-|Hsp20/alpha-crystallin-family-protein
MANMVPYDRYERALRRAFDPFDSFFSAPLSVLSNEGSFKMNVEDAGDKYVVTAELAGVNRDEIDVELNEGRLSISVDKKESEEDKGKNYLHKETTEWQASRGVYLKDATTSGLTAKLDGGVLTVNVPKQEEKASVTKVSID
>NZ_CP012069.2|WP_157051531.1|2768607_2769066_+|hypothetical-protein
MSETHSTATGHVTVSPRAAAGHTLHIEGTPSRVQPGFIRRRAPHHTQDAIDDIAQDGNSIGEYTHDSNVSIRGNVRGGAFSGMPYRRARSGIDQVKSGKYGRYLEIPKGRRSIFVSQEQQKRRRSALSLVAIIVFLVIAFLIVWRLIASVAQ
>NZ_CP012069.2|WP_050341712.1|2769747_2770365_+|response-regulator-transcription-factor
MRVMVVEDQAMLRESLAMAIDAQEDMQVAGMLADAAEAPDLVERIHPDLVLMDVCTENDSSGIVAAKQIKDQHPEVYVVIMTGMPDITFVQQTRAAGADSFVYKNVSTTELLSVIRSTMEGYSTFPARPRLATTALNLTDSEVEVLRLVCEAKSRREIASELFLSEGTVKRRISEILAKTGYDSIMKLAVNAVAKGYIVPRLRGV
>NZ_CP012069.2|WP_050341714.1|2770667_2771540_+|hypothetical-protein
MDIMRKGRVIPAFFAAIAAVAVCLFASGCLGTGPSEATKAQWKPKFVGTWDLQEAKGDSSYSAEDLQLVREMGYDFYLELKEDGTAALVIDDDKTSGTWEVKSENVATFSAEGDTMEMKLADGKLTAEEGNKSLTFVKSNTNKGSSTTGTTTPAAGNANGSSTSRSGSENSTTKVDLTPVTIADDEVCKIVVTSKGEDFTGDPGYSLTITNKSDKSIFVTDATDSFSVNGKMATAYLNVSIKGGMYADSFMYFTRDELGGGLDSLTAVEGEIEVYSDGDFEELGHYPFRM
>NZ_CP012069.2|WP_050341715.1|2771675_2773439_+|hypothetical-protein
MRSGVSRKSVLWAAGLGLLLLVLELALPSTTRVWPYPHESAYGTTGPMILMVPLLGLWTLSIWQRCPDAQVRCYLMRCAAMLALLQLVALVKYTAQSDAAVALGWYLYYPTIVYVPLLVLFCALKTTGLERRSWVRRLKVCLLVAGAILCLLVLTNDLHQLTFLFDPLDPLWDVRYSYGPVYGAVYAWLVLVLGAFYTLTAVYARGMRRRLVALVFVMTLLVFAYSISYNFRFDPALNSNFALTFTVSCVVNIEGCLQLGLFPAHKKLTRLFESMPFDVRLLTHSGETAFASKAAASVPDSVRERLTHFEMHPGARVTLEAPGEKDRLYRGFGVSGGYVLVSEDISELNERRQRLAVQLLQLRRRNRVLRHAHAVRESLYRQQCEEELLDEVDASLRETVQAIRRILASLPPTSDEPARIERRRKLLLVKLLVSYCKRKGALVLLGTDDTSFDAQHLRLVINESMADARSSELDCAAWVGLDRPLPIQTVNTIYDCMYDVLTAAFVRKDATLMVFVTEKEADLVELRCALETTKSEQSCPYALGDELRRRLEIRDVQFGLEEDEGVLHLNVLIAAPAAEPAAALTGT
>NZ_CP012069.2|WP_157051532.1|2773441_2774893_+|hypothetical-protein
MASGLVFPKHVVLEFMIVLLTLLATLQLTFALMRAAFLATSASERRGRLLGVLYAVFLCLDFVVMAAVCVSGAYGGPLLVLEFFSLRAPLMVLMWAVAPSMAVACMQVALLRRPLLLCDVVVLLAVLPPVAQELGPLWPFALILMVAYFVGRGVGDAGELLRLRKLGLTRFSPGEALSVVTEGMLCTRDDGRVLFMNDAMRSCLGELGLPLDLGDFRDLWERIVSLAAGGARSADGAKRGVRIRISADETRYFTCEPLSTRHKGRCIIAYDISERDQLDRRLERTGKGLERAGTELAESLQRVQEVARIQASLHMRSRVHDVIGQRVSILHRCLEDDRLPDETVATLEPLLVGILDDLRVHEADDPQASLAAVIAAFELVGVRFCVTGSLPADDEVAGLFVRVIREASTNALHHGQAHTIWLSMDQTARSAHLSVENDGTVPAAVRERGGIAGIRRRVANAGGSLSINREPRFSIHVEVPLAR
>NZ_CP012069.2|WP_050341720.1|2775163_2775469_-|hypothetical-protein
MRAELHVGRAATGDKLSGRGKTAGREGRLARRQASSGGRVIPAPTPTVAVEREHRLADGWGPIDALDASFLRAENEDDDGYDPFSDRPAAPEPLFERDPWK
>NZ_CP012069.2|WP_050341722.1|2775494_2777708_-|PASTA-domain-containing-protein
MAAEERDDVVESSEASEGQVNPVPGVEHEVEGTHAPKHAGGPAPESESVATPAHAAPLDFAAAPEVEDIAAPAHAAHAAHVAPESVAEAEPIEAPESAKHRPAHAAVPETESDTNAESNTNAESDTDVEFEDAAVPAPAHAAPEFDATPTPAHAAPGPAVEVTLTHTPAHAAPKDTIEADRVEAAEEPTAEMASGTASDTVPSLDLDATADSAAGSDAPHGNAVLLPIPTEELRNQGGDMSTDVFGRFVGGVVQQPLSGAVDAGDVDERGNGRHGRRVMRSKVVPGEGKSRSKARTLIVFLFMAAAMIAVGAFVAYGAELWGGKVVPDVVNKSQSLATTTLTEKGFSVSVVEERVDDGVGKVISVDPAIGSRLAVGSQVTLHVGVARTIPDVTGMPLDDAKAALEDVGAQNFTLTYQASSEVAGTVIAVEPAAGSNFSSNDTITLTIAQSHTIPYVLGKKEKSALSVIEAAGLKANVTYVKSDKDLGVVVSCSPEPGSKVKAGSTVDLEISASSPADYHHLVDYFSYNPKIISNFLSQQKFILEGNYIDPNNALEALYNSERKGTITFSPQPFSRSYDAGKGSTDSELLSEGTKFSGIRLDIPTSELPSGASSLSDSAVQAIMNLCGFTGKKQVVDQHSAKLPQSAHTAQPAQSTQSAPTTQQPTQTSHPTQSGSASFICAYGEMDDYYWTVLIANEGGTTRATATAAPKSLYSSLDLSQYDGSLCSFVAFSDIYAK

Crispr_ID: NZ_CP012069_33

• CRISPR_ID: NZ_CP012069_33
• CRISPR_location: 2774978-2775066
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_33

Consensus_repeat	Method
CCCCGCAGATTCTGGGGCACTAAGGAG	CRISPRCasFinder

spacers of NZ_CP012069_33

>33.1|2775005|35|NZ_CP012069|CRISPRCasFinder
AGGAGCTCAACTGGGCAAACGTCCACAGGAAGGTA

CRISPR arrays and Neighbor proteins around NZ_CP012069_33

CRISPR arrays

The CRISPR arrays of NZ_CP012069_33

>merge|NZ_CP012069|33|2774978-2775066|CRISPRCasFinder
CCCCGCAGATTCTGGGGCACTAAGGAGAGGAGCTCAACTGGGCAAACGTCCACAGGAAGGTACCCCGCAGATTCTGGGGCACTAAGGAG

>NZ_CP012069|33|30|2774978-2775066|CRISPRCasFinder
CCCCGCAGATTCTGGGGCACTAAGGAG	AGGAGCTCAACTGGGCAAACGTCCACAGGAAGGTA
CCCCGCAGATTCTGGGGCACTAAGGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_157051532.1|2773441_2774893_+|hypothetical-protein	unknown	unknown	gnl|CDD|340394
NZ_CP012069.2|WP_050341714.1|2770667_2771540_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341720.1|2775163_2775469_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051531.1|2768607_2769066_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_172674533.1|2762190_2763705_-|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl|CDD|238950
NZ_CP012069.2|WP_050341708.1|2766493_2767015_-|DUF5104-domain-containing-protein	unknown	unknown	gnl|CDD|379921
NZ_CP012069.2|WP_050341728.1|2779735_2782405_-|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl|CDD|274529
NZ_CP012069.2|WP_050341724.1|2778304_2778694_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341737.1|2787387_2788035_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341735.1|2786850_2787306_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051534.1|2786041_2786638_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341730.1|2782583_2784146_-|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl|CDD|308794
NZ_CP012069.2|WP_050341709.1|2767578_2768004_-|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl|CDD|223149
NZ_CP012069.2|WP_050341722.1|2775494_2777708_-|PASTA-domain-containing-protein	unknown	unknown	gnl|CDD|225372
NZ_CP012069.2|WP_050341715.1|2771675_2773439_+|hypothetical-protein	unknown	unknown	gnl|CDD|379902
NZ_CP012069.2|WP_050341712.1|2769747_2770365_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP012069.2|WP_050341738.1|2788036_2788690_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341732.1|2784147_2786040_-|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl|CDD|308794
NZ_CP012069.2|WP_050341706.1|2765923_2766445_-|DUF5104-domain-containing-protein	unknown	unknown	gnl|CDD|379921
NZ_CP012069.2|WP_050341700.1|2763771_2764992_-|peptidase-T	unknown	unknown	gnl|CDD|349887

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_157051532.1|2773441_2774893_+|hypothetical-protein	gnl|CDD|340394	cd16917, HATPase_UhpB-NarQ-NarX-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ. This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.	4.54351e-13
NZ_CP012069.2|WP_050341728.1|2779735_2782405_-|ATP-dependent-chaperone-ClpB	gnl|CDD|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP012069.2|WP_050341706.1|2765923_2766445_-|DUF5104-domain-containing-protein	gnl|CDD|379921	pfam17117, DUF5104, Domain of unknown function (DUF5104). This is a family of gut microbes of unknown function.	2.74297e-06
NZ_CP012069.2|WP_050341715.1|2771675_2773439_+|hypothetical-protein	gnl|CDD|379902	pfam16927, HisKA_7TM, N-terminal 7TM region of histidine kinase. HisKA_7TM is an N-terminal region consisting of seven transmembrane domains found in Archaea and some bacteria. It is always found associated with histidine kinase.	1.53499e-09
NZ_CP012069.2|WP_050341708.1|2766493_2767015_-|DUF5104-domain-containing-protein	gnl|CDD|379921	pfam17117, DUF5104, Domain of unknown function (DUF5104). This is a family of gut microbes of unknown function.	1.59344e-10
NZ_CP012069.2|WP_050341709.1|2767578_2768004_-|Hsp20/alpha-crystallin-family-protein	gnl|CDD|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	6.76752e-23
NZ_CP012069.2|WP_172674533.1|2762190_2763705_-|tRNA-lysidine(34)-synthetase-TilS	gnl|CDD|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	1.81126e-58
NZ_CP012069.2|WP_050341730.1|2782583_2784146_-|BspA-family-leucine-rich-repeat-surface-protein	gnl|CDD|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	1.54331e-27
NZ_CP012069.2|WP_050341712.1|2769747_2770365_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.09521e-43
NZ_CP012069.2|WP_050341732.1|2784147_2786040_-|BspA-family-leucine-rich-repeat-surface-protein	gnl|CDD|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	6.53353e-25
NZ_CP012069.2|WP_050341722.1|2775494_2777708_-|PASTA-domain-containing-protein	gnl|CDD|225372	COG2815, COG2815, Uncharacterized protein conserved in bacteria [Function unknown].	5.97495e-28
NZ_CP012069.2|WP_050341700.1|2763771_2764992_-|peptidase-T	gnl|CDD|349887	cd03892, M20_peptT, M20 Peptidase T specifically cleaves tripeptides. Peptidase M20 family, Peptidase T (peptT; tripeptide aminopeptidase; tripeptidase) subfamily. PepT acts only on tripeptide substrates, and is thus called a tripeptidase. It catalyzes the release of N-terminal amino acids with hydrophobic side chains from tripeptides with high specificity; dipeptides, tetrapeptides or tripeptides with the N-terminus blocked are not cleaved. Tripeptidases are known to function at the final stage of proteolysis in lactococcal bacteria and release amino acids from tripeptides produced during the digestion of milk proteins such as casein.	0

Protein sequences

>NZ_CP012069.2|WP_157051532.1|2773441_2774893_+|hypothetical-protein
MASGLVFPKHVVLEFMIVLLTLLATLQLTFALMRAAFLATSASERRGRLLGVLYAVFLCLDFVVMAAVCVSGAYGGPLLVLEFFSLRAPLMVLMWAVAPSMAVACMQVALLRRPLLLCDVVVLLAVLPPVAQELGPLWPFALILMVAYFVGRGVGDAGELLRLRKLGLTRFSPGEALSVVTEGMLCTRDDGRVLFMNDAMRSCLGELGLPLDLGDFRDLWERIVSLAAGGARSADGAKRGVRIRISADETRYFTCEPLSTRHKGRCIIAYDISERDQLDRRLERTGKGLERAGTELAESLQRVQEVARIQASLHMRSRVHDVIGQRVSILHRCLEDDRLPDETVATLEPLLVGILDDLRVHEADDPQASLAAVIAAFELVGVRFCVTGSLPADDEVAGLFVRVIREASTNALHHGQAHTIWLSMDQTARSAHLSVENDGTVPAAVRERGGIAGIRRRVANAGGSLSINREPRFSIHVEVPLAR
>NZ_CP012069.2|WP_050341715.1|2771675_2773439_+|hypothetical-protein
MRSGVSRKSVLWAAGLGLLLLVLELALPSTTRVWPYPHESAYGTTGPMILMVPLLGLWTLSIWQRCPDAQVRCYLMRCAAMLALLQLVALVKYTAQSDAAVALGWYLYYPTIVYVPLLVLFCALKTTGLERRSWVRRLKVCLLVAGAILCLLVLTNDLHQLTFLFDPLDPLWDVRYSYGPVYGAVYAWLVLVLGAFYTLTAVYARGMRRRLVALVFVMTLLVFAYSISYNFRFDPALNSNFALTFTVSCVVNIEGCLQLGLFPAHKKLTRLFESMPFDVRLLTHSGETAFASKAAASVPDSVRERLTHFEMHPGARVTLEAPGEKDRLYRGFGVSGGYVLVSEDISELNERRQRLAVQLLQLRRRNRVLRHAHAVRESLYRQQCEEELLDEVDASLRETVQAIRRILASLPPTSDEPARIERRRKLLLVKLLVSYCKRKGALVLLGTDDTSFDAQHLRLVINESMADARSSELDCAAWVGLDRPLPIQTVNTIYDCMYDVLTAAFVRKDATLMVFVTEKEADLVELRCALETTKSEQSCPYALGDELRRRLEIRDVQFGLEEDEGVLHLNVLIAAPAAEPAAALTGT
>NZ_CP012069.2|WP_050341714.1|2770667_2771540_+|hypothetical-protein
MDIMRKGRVIPAFFAAIAAVAVCLFASGCLGTGPSEATKAQWKPKFVGTWDLQEAKGDSSYSAEDLQLVREMGYDFYLELKEDGTAALVIDDDKTSGTWEVKSENVATFSAEGDTMEMKLADGKLTAEEGNKSLTFVKSNTNKGSSTTGTTTPAAGNANGSSTSRSGSENSTTKVDLTPVTIADDEVCKIVVTSKGEDFTGDPGYSLTITNKSDKSIFVTDATDSFSVNGKMATAYLNVSIKGGMYADSFMYFTRDELGGGLDSLTAVEGEIEVYSDGDFEELGHYPFRM
>NZ_CP012069.2|WP_050341712.1|2769747_2770365_+|response-regulator-transcription-factor
MRVMVVEDQAMLRESLAMAIDAQEDMQVAGMLADAAEAPDLVERIHPDLVLMDVCTENDSSGIVAAKQIKDQHPEVYVVIMTGMPDITFVQQTRAAGADSFVYKNVSTTELLSVIRSTMEGYSTFPARPRLATTALNLTDSEVEVLRLVCEAKSRREIASELFLSEGTVKRRISEILAKTGYDSIMKLAVNAVAKGYIVPRLRGV
>NZ_CP012069.2|WP_157051531.1|2768607_2769066_+|hypothetical-protein
MSETHSTATGHVTVSPRAAAGHTLHIEGTPSRVQPGFIRRRAPHHTQDAIDDIAQDGNSIGEYTHDSNVSIRGNVRGGAFSGMPYRRARSGIDQVKSGKYGRYLEIPKGRRSIFVSQEQQKRRRSALSLVAIIVFLVIAFLIVWRLIASVAQ
>NZ_CP012069.2|WP_050341709.1|2767578_2768004_-|Hsp20/alpha-crystallin-family-protein
MANMVPYDRYERALRRAFDPFDSFFSAPLSVLSNEGSFKMNVEDAGDKYVVTAELAGVNRDEIDVELNEGRLSISVDKKESEEDKGKNYLHKETTEWQASRGVYLKDATTSGLTAKLDGGVLTVNVPKQEEKASVTKVSID
>NZ_CP012069.2|WP_050341708.1|2766493_2767015_-|DUF5104-domain-containing-protein
MAGPITRRRLLAAGVALATATLPGCLGHRTDSEIEYDLSRRVLACLNEDDVDGLEALFCEASRARPELRAEIARGMGFFEGRVDLSAGWREGGWSTVSGGGLDVEGGRVLGRSVDPHVTGIVTDAGKRYGVRIYYCDVSVDHPDWVGVSEIDVIATRPDGEEGEKRVMGKILR
>NZ_CP012069.2|WP_050341706.1|2765923_2766445_-|DUF5104-domain-containing-protein
MAGPVTRRRLLAAGVALATATLPGCLGHRTDREIEHDLSRRVLACLNEDDADGLEALFCEASRARPELRAEIARGMGFFEGRVDLSAGWREGGWSTVSGGGLYAEGGRVLERSVDPHVTGIVIDAGRRYKVVICYCDVGVDHPDWVGVSEIDVIATRPDRHNGEKCAIGQYVK
>NZ_CP012069.2|WP_050341700.1|2763771_2764992_-|peptidase-T
MKAYERLLKYAVMRTPSDGKSAATPTTKQQFDLARLLVAELKELGVDDVTLSDECFVYAKLPATPGLEDKRRLGLIAHMDTVSQYCDHDIRPQLTPNYDGKDLSLGTSGRTLTVRDFPHLPSLRGRTLITSDGTTILGVDDKAGIAEIMTTLEIIRDKRIAHGPLRIAFTPDEETGTGASHFDVEHFDAEVAYTLDGDTEGEIQYQNFNACEATFEFRGVSVHPGSAKDVMVNAVLLALEANNMLPGLETPRYTEGYEGFYHLLSIHGDEARATSSYIVRDHRECSFEVRKATLRHIEKVMNELWGAGTVTLTIEEEYRNMESVIEGRMYLIDYARQAAERAGLRAEVSPIRGGTDGSQLSFRGLPCPNLGTGGHGYHGPFEHTTVEGMDLATTMAVELVKVYAQN
>NZ_CP012069.2|WP_172674533.1|2762190_2763705_-|tRNA-lysidine(34)-synthetase-TilS
MTSVMRRYATGEQRLGRPSSAAAGEMRAPVVLMVSGGADSTALLLLAVTSKLDIDDGRGLAHMARERLHVLHVNHQLRGEDSEGDEEFVRELARRHGIPCTVRRVDVAARARDASFPDANVESVGRDVRYAAARELANQLSAEFGTPRSAARILTAHTADDRAETFLMNAMRGSGVAGLSSIPRRRNRIVRPLLDRTHEDLCDFLRMRGIVWREDTTNADTRYLRSFVRHRVMPPIKERSPRVVSSLSTTCDILSEEDSYLTRVATRAFRDLVRRRSKGMLALDAAKLGACEVAIARRVVRMAMLELAPQARLEARHVDATLSLVAATHGSISTPMGCDVRVEYGLLFMRAHSVERSGEPFWLHVPGDHTLLDGSRLMARLADVPMGSDPVGMARSHGMEWEGLSVMLDAGACGVSRAPGSCLWVDGPVAGDLLCPLGMHGQSKKLSDLLNEARIPARDRASVPIVRTGPRGVIVWVAGVRADERARCTQSTRLLLELSLVRPD
>NZ_CP012069.2|WP_050341720.1|2775163_2775469_-|hypothetical-protein
MRAELHVGRAATGDKLSGRGKTAGREGRLARRQASSGGRVIPAPTPTVAVEREHRLADGWGPIDALDASFLRAENEDDDGYDPFSDRPAAPEPLFERDPWK
>NZ_CP012069.2|WP_050341722.1|2775494_2777708_-|PASTA-domain-containing-protein
MAAEERDDVVESSEASEGQVNPVPGVEHEVEGTHAPKHAGGPAPESESVATPAHAAPLDFAAAPEVEDIAAPAHAAHAAHVAPESVAEAEPIEAPESAKHRPAHAAVPETESDTNAESNTNAESDTDVEFEDAAVPAPAHAAPEFDATPTPAHAAPGPAVEVTLTHTPAHAAPKDTIEADRVEAAEEPTAEMASGTASDTVPSLDLDATADSAAGSDAPHGNAVLLPIPTEELRNQGGDMSTDVFGRFVGGVVQQPLSGAVDAGDVDERGNGRHGRRVMRSKVVPGEGKSRSKARTLIVFLFMAAAMIAVGAFVAYGAELWGGKVVPDVVNKSQSLATTTLTEKGFSVSVVEERVDDGVGKVISVDPAIGSRLAVGSQVTLHVGVARTIPDVTGMPLDDAKAALEDVGAQNFTLTYQASSEVAGTVIAVEPAAGSNFSSNDTITLTIAQSHTIPYVLGKKEKSALSVIEAAGLKANVTYVKSDKDLGVVVSCSPEPGSKVKAGSTVDLEISASSPADYHHLVDYFSYNPKIISNFLSQQKFILEGNYIDPNNALEALYNSERKGTITFSPQPFSRSYDAGKGSTDSELLSEGTKFSGIRLDIPTSELPSGASSLSDSAVQAIMNLCGFTGKKQVVDQHSAKLPQSAHTAQPAQSTQSAPTTQQPTQTSHPTQSGSASFICAYGEMDDYYWTVLIANEGGTTRATATAAPKSLYSSLDLSQYDGSLCSFVAFSDIYAK
>NZ_CP012069.2|WP_050341724.1|2778304_2778694_+|hypothetical-protein
METRYKLMRVTCKVKYNVNGDIAEIVDADGIEELELRPVEIESFIADGVEHVFRHPITVTVELDETGQVYLGLFELLDLCVYAEHQDELRREILDDLAWRWSAIAMASEDELAPDAIAVRNAFLDLVVE
>NZ_CP012069.2|WP_050341728.1|2779735_2782405_-|ATP-dependent-chaperone-ClpB
MRFDKWAVTAQEALQASLSIAADAEAGEVKPIHLLKALLSSGERNLRAIIERVGADPAQVEAQVDDIIARAPHVTGDMTQMNFSNEFIRVGDAAEKLASKMGDSYVTSEHLLCALADEKGDAGSALKGAGVTGKRIQEAFNDLRGDERVTSQDAKTQFDALEQYGRNVTDLARQGKLDPVIGRVEEIRRTVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAERIVAGDVPSTIKDKDIIELDMSALVAGAKYRGEFEDRLKSVLKEVKKSDGRVILFIDELHTIVGAGATEGSMDAGNILKPALARGELHAIGATTLDEYRKYIEKDQALARRFQTVYVSEPTVEDTVSILRGLKERYEQHHRVRITDAALVSAADLSNRYISDRFLPDKAIDLVDEAASRLRMELDSMPAEIDAVDRQLTQMQIEEQALMKEDDEASKERLATLQGEIAITREKLDGMKASWQNEKASVDRVQDLKGQIEDAKSEVDRAIRDGDLARASELRYSTIPTLQRQYDEAERDLSQRQDEGGILKEEVTPEEIAEVVSTWTGVPVSKMMQGEIEKLQNLEAQLHQRVIGQNEAVRAVAAAVRRSRAGLSDPNRPIGSFFFLGPTGVGKTELAKALAECLFDDEKALVRIDMSEYMEKFSVQRLIGAPPGYVGYDEGGQLTEAVRRRPYSVILLDEMEKAHPDVFNVLLQVLDDGRLTDGQGRVVSFKNTIIIMTSNVGSQFIAGANATSDPEKVQKLVNDALRQTFKPEFLNRIDDVVVFQSLGLADIEQIVDIQLKDVRKRLARERITLELSGAAIQSLSLDGLDPVYGARPLKRLIQRQVVDNVAGLIIDGKLHEGDTVRIDVGEGDHLVAVRDDEKSDNRSVAGSVSDPDGTPVEPDSFE
>NZ_CP012069.2|WP_050341730.1|2782583_2784146_-|BspA-family-leucine-rich-repeat-surface-protein
MCEMPCGSASSKRSDAAALEEPAVATWTAWDSCRCGLDADGTFWIAPAPGQREGTAKGEKRGTSVFTQFTRGIWHTQNKVHAVRVLGTVHLIGRAETLFWNSDSCVSMDLAGLDVSKVEDMSSMFEGCSSLERLDLSGWDTSRVEDMSSMFKDCNSLSTLNLTGWTVPKLRNLHETFCNCSSLLALDVSCWDTSKVTDLSHTFFGCSSLSSLDLSGWDTSRAEDLAYMLFGCSSLRELRLGPAFSFRPCVSFSGYRTRQSSPPNPPMTPPYSGNWAREDGSCELDARKLALRYGPALSGTWVWAHGTPSASPCANATRSLAWSQDEDSKGREPGSLRLRVYGLVRRLQRSEVSRFLSFELDPRDEADRGDAITLYLNGREGDFRVYASSSLGWVSLKGERIWFVMDEHRDGLSYQDLQDDIVYGGALGEGAYGEMLDLLFETVCVLASATDVFHDEVADEQRLRAPDLNPFDDCSYDVYVRNEHAGPYTKILANISFYVNCDPDETECELAAADQTPCNT
>NZ_CP012069.2|WP_050341732.1|2784147_2786040_-|BspA-family-leucine-rich-repeat-surface-protein
MDKTGQCEGAPRTSEDAAPINDTIVGGWHSWGSCRWGIDAGGTLWITPAAGRTEGTAQSLPKGETWIESSYGNGAPWRSRSKDIRSVKALGTVHLVGYANRMFAGLTHCKDMDLTGLDTSGLQDMTRMFYRCLSLTSLDLSGWDTSGVRSMEAVFNDCRGLVNLDLLGWDTSKVYSTVRMFCTCSSLVSLDLSGWNTSRVAGMSCMFSSCRKLVSVDMSGWDMSRVKFTDYMFSDCNSLASLDVSGWDMSQVAVTSGMFSNCFSLASLDVSGWDMSGVEEMYSMFSSCSSLKCLDVSGWNVRRARTMSGLFADCASLTSLDLSGWDMSGERDLGNLLRGCSSLREVRLGPRCPFLPYLLQEETAWVKLPDSSMGISYNNNWVREDGADRIKAAELAEGREVSPAGTWVRTTDTQAVGEPPERDEGAERIVCYGVSVGVLQVPEAERPPSYGIDLSSKEFIFFEERLECSDFSNFLTFSSERGIGCGRPGVPSPYLNGLDGDFWLSIASPFSQVHCRDELVWFVTESFRDRLTYQDLRGGIVYGGAIESVTSSEVAALLFETVRSFAGATDVYHTETVAEKRAHARDLNPFDDFRYDVYVRNTHSEPYTKTLANVTFHVNCDVRPSKSGRS
>NZ_CP012069.2|WP_157051534.1|2786041_2786638_-|hypothetical-protein
MGRIIRRRVRHAYWVGDGPVGLVERGDDFTRAEVDWFMRRLQRSQVSRFLTYDLQEESDGGFCLNLNGRVGDFYVGFGSDTLDVCFRGELVRFIEDSARDTYGYEDVYGDIIYNGPILDRPRAELIDLACEVVRIFAGATDVSHDEEADAKRWHSPSFDQIRDSSYDVYVKNAHTAPYRKTLANISFHVNCDAPGKRD
>NZ_CP012069.2|WP_050341735.1|2786850_2787306_-|hypothetical-protein
MADEGEVRIYVERGRWLDPPPRGMEFSWEEARRHLIDRLVQRRLALPLLRRRRDRREGVRLQPAFHWETGGFNAGIDPYNLDVCCMWEAGWFVPERFRSLTAHQDVQGEVVYGGPMEGGSHEEVLGLLFEVVCIFAGAEGIFHDETLPEWR
>NZ_CP012069.2|WP_050341737.1|2787387_2788035_-|hypothetical-protein
MGAEAGERRRLARAWSAEAGPAALRERRGLRDPGFSREEADWLMGRLQRSDASRFLSYRLHDERNDDYSLYLNGWVGGFYAHLDARSCEVCCLGECVHLADEAYRVGISRDAAYGEVVYAGPISGRTHEEILDLVFEVVRVFAGATDAFHEETRPAWKWRESDFGDFGDCIYDVYVRNAHTGPYRRTLANITFHVNCDTEWKDWPWEGPWEVELG
>NZ_CP012069.2|WP_050341738.1|2788036_2788690_-|hypothetical-protein
MGETVRRRFNYPVEVEWSEVPQLRRFVERTGLMDLDAAWELSDSLAMSDVSRFMTCDPKKEGERGHALCLNGPDGDFRVESEPGIARVRIMGERVWLVDERVRAEVAPRVGEGDVAYAGPISGRTQREVLALLYALVRALAGATGVFHDELRRPGGWDGPAGDPFSGRSYDVYVRNDHTGPYLLSLDNITLHVNRDAEPADWEGFGDLPAPAAGEGV

Crispr_ID: NZ_CP012069_34

• CRISPR_ID: NZ_CP012069_34
• CRISPR_location: 2785058-2785485
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of NZ_CP012069_34

Consensus_repeat	Method
GACATGTCCCAACCCGAGACGTCGAGGGAGGCGAGCGA	CRISPRCasFinder

spacers of NZ_CP012069_34

>34.1|2785096|40|NZ_CP012069|CRISPRCasFinder
CGCGCAGTCTGCGAACAGGCCGGACATCGTCCTTGCCCTG
>34.2|2785174|40|NZ_CP012069|CRISPRCasFinder
AGAACAGCTGCTAAACATGCTATACATCTCCTCCACCCCG
>34.3|2785252|40|NZ_CP012069|CRISPRCasFinder
GAAACAGTTCGAGAACATACCGGAAGTAACTGCCACCTGC
>34.4|2785330|40|NZ_CP012069|CRISPRCasFinder
ATTGCAGTCCGAGAACATGTAGTCGGTAAACTTCACCCGT
>34.5|2785408|40|NZ_CP012069|CRISPRCasFinder
TCTGCAGGAGGAAAACATGCACGACATCCCCGCTACCCTC

CRISPR arrays and Neighbor proteins around NZ_CP012069_34

CRISPR arrays

The CRISPR arrays of NZ_CP012069_34

>merge|NZ_CP012069|34|2785058-2785485|CRISPRCasFinder
GACATGTCCCAACCCGAGAGGTCAAGGGAGGTAAGGGACGCGCAGTCTGCGAACAGGCCGGACATCGTCCTTGCCCTGCGCACGTTCCAGCCCGAGACGTCAAGACACTTGAGGGAAGAACAGCTGCTAAACATGCTATACATCTCCTCCACCCCGGACATGTCCCAACCCGAGACGTCGAGGGAGGCGAGCGAGAAACAGTTCGAGAACATACCGGAAGTAACTGCCACCTGCGACATGTCCCAACCCGAGACGTCGAGGGAGGCGAGCGAATTGCAGTCCGAGAACATGTAGTCGGTAAACTTCACCCGTGACATGTCCCAACCTGACATATCGACGGAGACGAGCTTTCTGCAGGAGGAAAACATGCACGACATCCCCGCTACCCTCGATGTGTTCCAACCTGAGAGGTCAAGGGAGACGAGCGA

>NZ_CP012069|34|31|2785058-2785485|CRISPRCasFinder
GACATGTCCCAACCCGAGAGGTCAAGGGAGGTAAGGGA	CGCGCAGTCTGCGAACAGGCCGGACATCGTCCTTGCCCTG
CGCACGTTCCAGCCCGAGACGTCAAGACACTTGAGGGA	AGAACAGCTGCTAAACATGCTATACATCTCCTCCACCCCG
GACATGTCCCAACCCGAGACGTCGAGGGAGGCGAGCGA	GAAACAGTTCGAGAACATACCGGAAGTAACTGCCACCTGC
GACATGTCCCAACCCGAGACGTCGAGGGAGGCGAGCGA	ATTGCAGTCCGAGAACATGTAGTCGGTAAACTTCACCCGT
GACATGTCCCAACCTGACATATCGACGGAGACGAGCTT	TCTGCAGGAGGAAAACATGCACGACATCCCCGCTACCCTC
GATGTGTTCCAACCTGAGAGGTCAAGGGAGACGAGCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050341728.1|2779735_2782405_-|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl|CDD|274529
NZ_CP012069.2|WP_157051532.1|2773441_2774893_+|hypothetical-protein	unknown	unknown	gnl|CDD|340394
NZ_CP012069.2|WP_157051534.1|2786041_2786638_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051531.1|2768607_2769066_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341730.1|2782583_2784146_-|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl|CDD|308794
NZ_CP012069.2|WP_050341738.1|2788036_2788690_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341724.1|2778304_2778694_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051535.1|2789588_2790242_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341714.1|2770667_2771540_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341737.1|2787387_2788035_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341741.1|2788948_2789587_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341735.1|2786850_2787306_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341720.1|2775163_2775469_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341751.1|2793727_2794903_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224582
NZ_CP012069.2|WP_050341715.1|2771675_2773439_+|hypothetical-protein	unknown	unknown	gnl|CDD|379902
NZ_CP012069.2|WP_050341712.1|2769747_2770365_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP012069.2|WP_050341747.1|2791901_2792579_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
NZ_CP012069.2|WP_157051536.1|2792571_2793654_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050341722.1|2775494_2777708_-|PASTA-domain-containing-protein	unknown	unknown	gnl|CDD|225372
NZ_CP012069.2|WP_050341745.1|2790342_2791713_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050341728.1|2779735_2782405_-|ATP-dependent-chaperone-ClpB	gnl|CDD|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP012069.2|WP_157051532.1|2773441_2774893_+|hypothetical-protein	gnl|CDD|340394	cd16917, HATPase_UhpB-NarQ-NarX-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ. This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.	4.54351e-13
NZ_CP012069.2|WP_050341747.1|2791901_2792579_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.08608e-52
NZ_CP012069.2|WP_050341730.1|2782583_2784146_-|BspA-family-leucine-rich-repeat-surface-protein	gnl|CDD|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	1.54331e-27
NZ_CP012069.2|WP_050341715.1|2771675_2773439_+|hypothetical-protein	gnl|CDD|379902	pfam16927, HisKA_7TM, N-terminal 7TM region of histidine kinase. HisKA_7TM is an N-terminal region consisting of seven transmembrane domains found in Archaea and some bacteria. It is always found associated with histidine kinase.	1.53499e-09
NZ_CP012069.2|WP_050341712.1|2769747_2770365_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.09521e-43
NZ_CP012069.2|WP_050341722.1|2775494_2777708_-|PASTA-domain-containing-protein	gnl|CDD|225372	COG2815, COG2815, Uncharacterized protein conserved in bacteria [Function unknown].	5.97495e-28
NZ_CP012069.2|WP_050341751.1|2793727_2794903_-|ABC-transporter-permease	gnl|CDD|224582	COG1668, NatB, ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism].	6.09752e-21

Protein sequences

>NZ_CP012069.2|WP_050341730.1|2782583_2784146_-|BspA-family-leucine-rich-repeat-surface-protein
MCEMPCGSASSKRSDAAALEEPAVATWTAWDSCRCGLDADGTFWIAPAPGQREGTAKGEKRGTSVFTQFTRGIWHTQNKVHAVRVLGTVHLIGRAETLFWNSDSCVSMDLAGLDVSKVEDMSSMFEGCSSLERLDLSGWDTSRVEDMSSMFKDCNSLSTLNLTGWTVPKLRNLHETFCNCSSLLALDVSCWDTSKVTDLSHTFFGCSSLSSLDLSGWDTSRAEDLAYMLFGCSSLRELRLGPAFSFRPCVSFSGYRTRQSSPPNPPMTPPYSGNWAREDGSCELDARKLALRYGPALSGTWVWAHGTPSASPCANATRSLAWSQDEDSKGREPGSLRLRVYGLVRRLQRSEVSRFLSFELDPRDEADRGDAITLYLNGREGDFRVYASSSLGWVSLKGERIWFVMDEHRDGLSYQDLQDDIVYGGALGEGAYGEMLDLLFETVCVLASATDVFHDEVADEQRLRAPDLNPFDDCSYDVYVRNEHAGPYTKILANISFYVNCDPDETECELAAADQTPCNT
>NZ_CP012069.2|WP_050341728.1|2779735_2782405_-|ATP-dependent-chaperone-ClpB
MRFDKWAVTAQEALQASLSIAADAEAGEVKPIHLLKALLSSGERNLRAIIERVGADPAQVEAQVDDIIARAPHVTGDMTQMNFSNEFIRVGDAAEKLASKMGDSYVTSEHLLCALADEKGDAGSALKGAGVTGKRIQEAFNDLRGDERVTSQDAKTQFDALEQYGRNVTDLARQGKLDPVIGRVEEIRRTVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAERIVAGDVPSTIKDKDIIELDMSALVAGAKYRGEFEDRLKSVLKEVKKSDGRVILFIDELHTIVGAGATEGSMDAGNILKPALARGELHAIGATTLDEYRKYIEKDQALARRFQTVYVSEPTVEDTVSILRGLKERYEQHHRVRITDAALVSAADLSNRYISDRFLPDKAIDLVDEAASRLRMELDSMPAEIDAVDRQLTQMQIEEQALMKEDDEASKERLATLQGEIAITREKLDGMKASWQNEKASVDRVQDLKGQIEDAKSEVDRAIRDGDLARASELRYSTIPTLQRQYDEAERDLSQRQDEGGILKEEVTPEEIAEVVSTWTGVPVSKMMQGEIEKLQNLEAQLHQRVIGQNEAVRAVAAAVRRSRAGLSDPNRPIGSFFFLGPTGVGKTELAKALAECLFDDEKALVRIDMSEYMEKFSVQRLIGAPPGYVGYDEGGQLTEAVRRRPYSVILLDEMEKAHPDVFNVLLQVLDDGRLTDGQGRVVSFKNTIIIMTSNVGSQFIAGANATSDPEKVQKLVNDALRQTFKPEFLNRIDDVVVFQSLGLADIEQIVDIQLKDVRKRLARERITLELSGAAIQSLSLDGLDPVYGARPLKRLIQRQVVDNVAGLIIDGKLHEGDTVRIDVGEGDHLVAVRDDEKSDNRSVAGSVSDPDGTPVEPDSFE
>NZ_CP012069.2|WP_050341724.1|2778304_2778694_+|hypothetical-protein
METRYKLMRVTCKVKYNVNGDIAEIVDADGIEELELRPVEIESFIADGVEHVFRHPITVTVELDETGQVYLGLFELLDLCVYAEHQDELRREILDDLAWRWSAIAMASEDELAPDAIAVRNAFLDLVVE
>NZ_CP012069.2|WP_050341722.1|2775494_2777708_-|PASTA-domain-containing-protein
MAAEERDDVVESSEASEGQVNPVPGVEHEVEGTHAPKHAGGPAPESESVATPAHAAPLDFAAAPEVEDIAAPAHAAHAAHVAPESVAEAEPIEAPESAKHRPAHAAVPETESDTNAESNTNAESDTDVEFEDAAVPAPAHAAPEFDATPTPAHAAPGPAVEVTLTHTPAHAAPKDTIEADRVEAAEEPTAEMASGTASDTVPSLDLDATADSAAGSDAPHGNAVLLPIPTEELRNQGGDMSTDVFGRFVGGVVQQPLSGAVDAGDVDERGNGRHGRRVMRSKVVPGEGKSRSKARTLIVFLFMAAAMIAVGAFVAYGAELWGGKVVPDVVNKSQSLATTTLTEKGFSVSVVEERVDDGVGKVISVDPAIGSRLAVGSQVTLHVGVARTIPDVTGMPLDDAKAALEDVGAQNFTLTYQASSEVAGTVIAVEPAAGSNFSSNDTITLTIAQSHTIPYVLGKKEKSALSVIEAAGLKANVTYVKSDKDLGVVVSCSPEPGSKVKAGSTVDLEISASSPADYHHLVDYFSYNPKIISNFLSQQKFILEGNYIDPNNALEALYNSERKGTITFSPQPFSRSYDAGKGSTDSELLSEGTKFSGIRLDIPTSELPSGASSLSDSAVQAIMNLCGFTGKKQVVDQHSAKLPQSAHTAQPAQSTQSAPTTQQPTQTSHPTQSGSASFICAYGEMDDYYWTVLIANEGGTTRATATAAPKSLYSSLDLSQYDGSLCSFVAFSDIYAK
>NZ_CP012069.2|WP_050341720.1|2775163_2775469_-|hypothetical-protein
MRAELHVGRAATGDKLSGRGKTAGREGRLARRQASSGGRVIPAPTPTVAVEREHRLADGWGPIDALDASFLRAENEDDDGYDPFSDRPAAPEPLFERDPWK
>NZ_CP012069.2|WP_157051532.1|2773441_2774893_+|hypothetical-protein
MASGLVFPKHVVLEFMIVLLTLLATLQLTFALMRAAFLATSASERRGRLLGVLYAVFLCLDFVVMAAVCVSGAYGGPLLVLEFFSLRAPLMVLMWAVAPSMAVACMQVALLRRPLLLCDVVVLLAVLPPVAQELGPLWPFALILMVAYFVGRGVGDAGELLRLRKLGLTRFSPGEALSVVTEGMLCTRDDGRVLFMNDAMRSCLGELGLPLDLGDFRDLWERIVSLAAGGARSADGAKRGVRIRISADETRYFTCEPLSTRHKGRCIIAYDISERDQLDRRLERTGKGLERAGTELAESLQRVQEVARIQASLHMRSRVHDVIGQRVSILHRCLEDDRLPDETVATLEPLLVGILDDLRVHEADDPQASLAAVIAAFELVGVRFCVTGSLPADDEVAGLFVRVIREASTNALHHGQAHTIWLSMDQTARSAHLSVENDGTVPAAVRERGGIAGIRRRVANAGGSLSINREPRFSIHVEVPLAR
>NZ_CP012069.2|WP_050341715.1|2771675_2773439_+|hypothetical-protein
MRSGVSRKSVLWAAGLGLLLLVLELALPSTTRVWPYPHESAYGTTGPMILMVPLLGLWTLSIWQRCPDAQVRCYLMRCAAMLALLQLVALVKYTAQSDAAVALGWYLYYPTIVYVPLLVLFCALKTTGLERRSWVRRLKVCLLVAGAILCLLVLTNDLHQLTFLFDPLDPLWDVRYSYGPVYGAVYAWLVLVLGAFYTLTAVYARGMRRRLVALVFVMTLLVFAYSISYNFRFDPALNSNFALTFTVSCVVNIEGCLQLGLFPAHKKLTRLFESMPFDVRLLTHSGETAFASKAAASVPDSVRERLTHFEMHPGARVTLEAPGEKDRLYRGFGVSGGYVLVSEDISELNERRQRLAVQLLQLRRRNRVLRHAHAVRESLYRQQCEEELLDEVDASLRETVQAIRRILASLPPTSDEPARIERRRKLLLVKLLVSYCKRKGALVLLGTDDTSFDAQHLRLVINESMADARSSELDCAAWVGLDRPLPIQTVNTIYDCMYDVLTAAFVRKDATLMVFVTEKEADLVELRCALETTKSEQSCPYALGDELRRRLEIRDVQFGLEEDEGVLHLNVLIAAPAAEPAAALTGT
>NZ_CP012069.2|WP_050341714.1|2770667_2771540_+|hypothetical-protein
MDIMRKGRVIPAFFAAIAAVAVCLFASGCLGTGPSEATKAQWKPKFVGTWDLQEAKGDSSYSAEDLQLVREMGYDFYLELKEDGTAALVIDDDKTSGTWEVKSENVATFSAEGDTMEMKLADGKLTAEEGNKSLTFVKSNTNKGSSTTGTTTPAAGNANGSSTSRSGSENSTTKVDLTPVTIADDEVCKIVVTSKGEDFTGDPGYSLTITNKSDKSIFVTDATDSFSVNGKMATAYLNVSIKGGMYADSFMYFTRDELGGGLDSLTAVEGEIEVYSDGDFEELGHYPFRM
>NZ_CP012069.2|WP_050341712.1|2769747_2770365_+|response-regulator-transcription-factor
MRVMVVEDQAMLRESLAMAIDAQEDMQVAGMLADAAEAPDLVERIHPDLVLMDVCTENDSSGIVAAKQIKDQHPEVYVVIMTGMPDITFVQQTRAAGADSFVYKNVSTTELLSVIRSTMEGYSTFPARPRLATTALNLTDSEVEVLRLVCEAKSRREIASELFLSEGTVKRRISEILAKTGYDSIMKLAVNAVAKGYIVPRLRGV
>NZ_CP012069.2|WP_157051531.1|2768607_2769066_+|hypothetical-protein
MSETHSTATGHVTVSPRAAAGHTLHIEGTPSRVQPGFIRRRAPHHTQDAIDDIAQDGNSIGEYTHDSNVSIRGNVRGGAFSGMPYRRARSGIDQVKSGKYGRYLEIPKGRRSIFVSQEQQKRRRSALSLVAIIVFLVIAFLIVWRLIASVAQ
>NZ_CP012069.2|WP_157051534.1|2786041_2786638_-|hypothetical-protein
MGRIIRRRVRHAYWVGDGPVGLVERGDDFTRAEVDWFMRRLQRSQVSRFLTYDLQEESDGGFCLNLNGRVGDFYVGFGSDTLDVCFRGELVRFIEDSARDTYGYEDVYGDIIYNGPILDRPRAELIDLACEVVRIFAGATDVSHDEEADAKRWHSPSFDQIRDSSYDVYVKNAHTAPYRKTLANISFHVNCDAPGKRD
>NZ_CP012069.2|WP_050341735.1|2786850_2787306_-|hypothetical-protein
MADEGEVRIYVERGRWLDPPPRGMEFSWEEARRHLIDRLVQRRLALPLLRRRRDRREGVRLQPAFHWETGGFNAGIDPYNLDVCCMWEAGWFVPERFRSLTAHQDVQGEVVYGGPMEGGSHEEVLGLLFEVVCIFAGAEGIFHDETLPEWR
>NZ_CP012069.2|WP_050341737.1|2787387_2788035_-|hypothetical-protein
MGAEAGERRRLARAWSAEAGPAALRERRGLRDPGFSREEADWLMGRLQRSDASRFLSYRLHDERNDDYSLYLNGWVGGFYAHLDARSCEVCCLGECVHLADEAYRVGISRDAAYGEVVYAGPISGRTHEEILDLVFEVVRVFAGATDAFHEETRPAWKWRESDFGDFGDCIYDVYVRNAHTGPYRRTLANITFHVNCDTEWKDWPWEGPWEVELG
>NZ_CP012069.2|WP_050341738.1|2788036_2788690_-|hypothetical-protein
MGETVRRRFNYPVEVEWSEVPQLRRFVERTGLMDLDAAWELSDSLAMSDVSRFMTCDPKKEGERGHALCLNGPDGDFRVESEPGIARVRIMGERVWLVDERVRAEVAPRVGEGDVAYAGPISGRTQREVLALLYALVRALAGATGVFHDELRRPGGWDGPAGDPFSGRSYDVYVRNDHTGPYLLSLDNITLHVNRDAEPADWEGFGDLPAPAAGEGV
>NZ_CP012069.2|WP_050341741.1|2788948_2789587_-|hypothetical-protein
MGAEVGERRRFARAWPVEAGPADLRVRRGLGFSREEAAWLMGRLQRSDVSRFLSYQIIGEDDDGYSLYLNGWVGELYVSLDALSCEVYCLGECVHLADEDYRVGISCDTAWEEVVYAGPISGRTHEEILDLVFEVVRVFAGATGVFHEETRPAWKWRESDFGDFGDCIYDVYVRNDHTGPYRRTLSNITFHVNCDTEWGDQPWEGPWEVELG
>NZ_CP012069.2|WP_157051535.1|2789588_2790242_-|hypothetical-protein
MGETVRRRFNYPVGVEWPRVLAWVRERERLGLVGFGAARDLSRTLQGSDVSRFMTYEFKMEGERGRTLCLNGPDGDFRVEIEHDLAKVRIMGECIWFVDERARGEAAPRVREGDVAYAGSISGRARGEVLMLLHALVRALAGATGVFHDELRRPGGWDGPAGDPFSGRSYDIYVRNDHTGPYLLSLDNITLHVNRDAEPADWEGFGSFPAPAAGAGG
>NZ_CP012069.2|WP_050341745.1|2790342_2791713_-|hypothetical-protein
MRQICRRLLVAVLSVSLCFSTLPPTRVLARGWAATVGAEARTPADADLGAWAAGGAPGVRVASVDADDVDADEDGDAGEPYLGEGAVTLSESAVTIDGVEISRAQFCAAALPGMARLQDTPETGAMSEYARLLSLSAAAEGAVLELGHAIEMTFIRLLMRENIARILALGGAGAFLICAGSIPGVDRDIIVVVTVLGTVALDGVIIGASWLGLDISSYIVDNYSSISVTVPSTTWGTLDPGVQQTLVDARTRLLERLDELVETKSLEKKDRNDASVVVVGHNRRTKQSAIGVKLSEGRPGAIKILQKLSGSYYTCGLPIEWQIGKDSKDDEDRSCAETACVRALGGLYMDKPGGRGQVIRPEIENIVMIQPFRPRPIDGDFKLVPVCEKCERQFGRQRFVRGTIFKSDVESSGGTQQADCSVACLRVRWACEHELCPILTLNGRGGDLRKDMPSAA
>NZ_CP012069.2|WP_050341747.1|2791901_2792579_-|ABC-transporter-ATP-binding-protein
MLELKGVERRFASGKGIGPVSFCVRQGEVCSVVGPNGAGKSTLFGILSMVSEEFTGSWSLDGRVGRQIPRGAIGYLPESTFLISSFTPRQFCSFDASMRGVPHTAASIEEHLETFACKDFIDVPLGELSQGMAKRVALACAFLGEPRLVLLDEPLNAIDIQTTLILKDRIVSESERGCTLLISSHILDFLDEVSDRMLFLREGDIADDFDPRDGGAEGRYRELFL
>NZ_CP012069.2|WP_157051536.1|2792571_2793654_-|hypothetical-protein
MTMTGSFLRHLLASGGVRYLKKSAWFSCLIVNLLFVALSIYVAGRLSSGAVALGIRLAATLGISIGLCLAALSAPSEFLRRDLRPQGVSYLRFCGFGNEDFLRLGAALTLPCAVITGVSVGVMALALTQSLLISLAAAAFVCAGLVALGAAVATVVLRGGLVHAAARRRARAIVFSSNRVVCRAQRNALLAKKRALLFEVALWLCIDCVFCVLQWPPVGYMIVVRFPAACILMEFALVYDDPAVKFQERYYREGLLVRALALVIPGACIATACVIATVPISLLFGGAGAAGVSFLSTVIPCCLLQLILGAAMLLVFEKRPLLPLWQTAIGCGVFALGLIEVASLVVVGVGWGRRTWRGHA
>NZ_CP012069.2|WP_050341751.1|2793727_2794903_-|ABC-transporter-permease
MRNDTLSIFKKEMDRFLHNKASAAAAIILPGLFIFLLWTIMGNTLRTSANKAESISELTIYAVNPSQNIGQIASSAGMTITEISGLPTKEEMHDQIESGSAQAYIAFPEDFDRQIEVGTGPGGTVPQIEVYYNSSDTKSALAYTTIQTMLDQYETSFDNRFDVNRAGEGYDLMRSQDQTSQFAVAFVPFMLLVLVFSSSMSVAAEAIAGEKERGTIATLLATPINRQDIARGKILACSLIGLAIAASSSIGIFLSLPSLMRGQFDAGSYGPVELCLLGLVVLSVTLLVVTIIVIVSTLATSTKEAQTWLTPIMMAVMGIGIVGIASKGVQTNPLFYALPLYNGVESMIGILSFRIDLASIAVCIGSNIVFSLLGLLVLERLFKSERVMFAH

Crispr_ID: NZ_CP012069_35

• CRISPR_ID: NZ_CP012069_35
• CRISPR_location: 3116548-3116685
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_35

Consensus_repeat	Method
GCACTGCCACTCGCCCTCGAGCGTACCGGACGCACTGCCACTCG	CRISPRCasFinder

spacers of NZ_CP012069_35

>35.1|3116592|50|NZ_CP012069|CRISPRCasFinder
ACCCTGAACGTTCCGCCCCGCACGTTCACCGCCGAGTGGCAGTGTGAGAG

CRISPR arrays and Neighbor proteins around NZ_CP012069_35

CRISPR arrays

The CRISPR arrays of NZ_CP012069_35

>merge|NZ_CP012069|35|3116548-3116685|CRISPRCasFinder
GCACTGCCACTCGCCCTCGAGCGTACCGGACGCACTGCCACTCGACCCTGAACGTTCCGCCCCGCACGTTCACCGCCGAGTGGCAGTGTGAGAGGCACTGCCACTCGCCCTCGAGCGTACCGGACGCACTGCCACTCG

>NZ_CP012069|35|32|3116548-3116685|CRISPRCasFinder
GCACTGCCACTCGCCCTCGAGCGTACCGGACGCACTGCCACTCG	ACCCTGAACGTTCCGCCCCGCACGTTCACCGCCGAGTGGCAGTGTGAGAG
GCACTGCCACTCGCCCTCGAGCGTACCGGACGCACTGCCACTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342238.1|3124505_3126197_+|glucose-6-phosphate-isomerase	unknown	unknown	gnl|CDD|234679
NZ_CP012069.2|WP_157051606.1|3119846_3121199_+|histidine-kinase	unknown	unknown	gnl|CDD|225814
NZ_CP012069.2|WP_050342227.1|3122057_3122513_+|YfcE-family-phosphodiesterase	unknown	unknown	gnl|CDD|223695
NZ_CP012069.2|WP_050342233.1|3123370_3123688_-|thioredoxin	unknown	unknown	gnl|CDD|200072
NZ_CP012069.2|WP_050342211.1|3111165_3112224_+|putrescine-carbamoyltransferase	unknown	unknown	gnl|CDD|235017
NZ_CP012069.2|WP_083444048.1|3117848_3118580_+|QueT-transporter-family-protein	unknown	unknown	gnl|CDD|377623
NZ_CP012069.2|WP_050342205.1|3104642_3105608_+|carbamate-kinase	unknown	unknown	gnl|CDD|237071
NZ_CP012069.2|WP_050344624.1|3109704_3110688_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197715
NZ_CP012069.2|WP_050342217.1|3115422_3116118_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342236.1|3123826_3124381_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083444049.1|3122493_3123252_-|phosphatase-PAP2-family-protein	unknown	unknown	gnl|CDD|239486
NZ_CP012069.2|WP_050342215.1|3113549_3114923_+|APC-family-permease	unknown	unknown	gnl|CDD|223605
NZ_CP012069.2|WP_050344625.1|3121305_3122046_+|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|236956
NZ_CP012069.2|WP_050342204.1|3103262_3103847_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342210.1|3108740_3109280_-|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl|CDD|379128
NZ_CP012069.2|WP_050342208.1|3107884_3108754_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl|CDD|378065
NZ_CP012069.2|WP_050342207.1|3106003_3106945_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342213.1|3112318_3113485_+|agmatine-deiminase	unknown	unknown	gnl|CDD|184135
NZ_CP012069.2|WP_083444050.1|3126307_3127243_-|AmmeMemoRadiSam-system-radical-SAM-enzyme	unknown	unknown	gnl|CDD|275136
NZ_CP012069.2|WP_050342221.1|3118585_3119845_+|glycosyltransferase	unknown	unknown	gnl|CDD|372656

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342238.1|3124505_3126197_+|glucose-6-phosphate-isomerase	gnl|CDD|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NZ_CP012069.2|WP_157051606.1|3119846_3121199_+|histidine-kinase	gnl|CDD|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	3.92958e-70
NZ_CP012069.2|WP_050342227.1|3122057_3122513_+|YfcE-family-phosphodiesterase	gnl|CDD|223695	COG0622, COG0622, Predicted phosphoesterase [General function prediction only].	1.42515e-21
NZ_CP012069.2|WP_050342211.1|3111165_3112224_+|putrescine-carbamoyltransferase	gnl|CDD|235017	PRK02255, PRK02255, putrescine carbamoyltransferase; Provisional.	0
NZ_CP012069.2|WP_083444048.1|3117848_3118580_+|QueT-transporter-family-protein	gnl|CDD|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	1.28207e-39
NZ_CP012069.2|WP_050342205.1|3104642_3105608_+|carbamate-kinase	gnl|CDD|237071	PRK12353, PRK12353, putative amino acid kinase; Reviewed.	0
NZ_CP012069.2|WP_050342221.1|3118585_3119845_+|glycosyltransferase	gnl|CDD|372656	pfam13641, Glyco_tranf_2_3, Glycosyltransferase like family 2. Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.	0.000545412
NZ_CP012069.2|WP_083444049.1|3122493_3123252_-|phosphatase-PAP2-family-protein	gnl|CDD|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.41159e-44
NZ_CP012069.2|WP_050342215.1|3113549_3114923_+|APC-family-permease	gnl|CDD|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	8.67702e-32
NZ_CP012069.2|WP_050344625.1|3121305_3122046_+|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	gnl|CDD|236956	PRK11697, PRK11697, two-component system response regulator BtsR.	4.15761e-55
NZ_CP012069.2|WP_050342210.1|3108740_3109280_-|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl|CDD|379128	pfam13338, AbiEi_4, Transcriptional regulator, AbiEi antitoxin. AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	0.000173181
NZ_CP012069.2|WP_050342208.1|3107884_3108754_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl|CDD|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	4.99133e-24
NZ_CP012069.2|WP_050344624.1|3109704_3110688_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	1.32012e-16
NZ_CP012069.2|WP_050342213.1|3112318_3113485_+|agmatine-deiminase	gnl|CDD|184135	PRK13551, PRK13551, agmatine deiminase; Provisional.	0
NZ_CP012069.2|WP_083444050.1|3126307_3127243_-|AmmeMemoRadiSam-system-radical-SAM-enzyme	gnl|CDD|275136	TIGR04337, Radical_SAM, AmmeMemoRadiSam system radical SAM enzyme. Members of this protein family are uncharacterized radical SAM enzymes that occur in a prokaryotic three-gene system along with homologs of mammalian proteins Memo (Mediator of ErbB2-driven cell MOtility) and AMMERCR1 (Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis). Among radical SAM enzymes that have been experimentally characterized, the most closely related in sequence include activases of pyruvate formate-lyase and of benzylsuccinate synthase.	5.66431e-74
NZ_CP012069.2|WP_050342233.1|3123370_3123688_-|thioredoxin	gnl|CDD|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	7.8406e-48

Protein sequences

>NZ_CP012069.2|WP_050342217.1|3115422_3116118_+|hypothetical-protein
MRAPGDTVARTGAAQTDGAFQLGKPELVCRWRLAGARLPLENRHLRALGRRHVNSGEMDKALVAWAKQHIEWTLADGGALHPDGVLMLIVDESGRAAMTVGPHKSLACRSTSALIARARESWYEGLVTGVSPESVWIVSEGTLVWGIPEDSAPSGATSLVEDLARTLGIPVERSKSLLDDLDNGELGYDEFFLVSDEHGIVKAADAPGSEGERFQRSYERLLDQVRRGRLR
>NZ_CP012069.2|WP_050342215.1|3113549_3114923_+|APC-family-permease
MAGTKRFSLLDAILNMICVVFVAEAAAPAAAIGNSQYFWWLMLIITFLLPYGMIVSELGSTYPDDEGGVYDWVKRAFGKRVAGFVAWSYWVNFPLWMASLALVFPDTIGTLMGIQLGSVPSLAIELAFIWTVVFVSFSKASDAAWLVNVGAVLKVGIAIVLGVLGFMYMSQHGNANAGDISTYLPNLADTSSLTYLSIILFNFMGFEVLATYTDEMDEPQRQIPQAIVYAGAAIAVVYLVSAFGIGVAIPVADLTVDSGISDALSVMVGTASPIFVVVSVVFLLTLIGNMVSWSLGVNTVAAKSAEDHNLPGFMGHKDPKTGMPNGASLTNGVVASILCAVSVFTGFDFWVLFAAQIVFLLLAYVPMFPAFLSLRASDPDTRRPFKVPGKGAVLKVITYLPVALLILSVIATCVPLSGEEVADKLPILALTIVLLAAGVSLMVVLNRQDPRPGDIVE
>NZ_CP012069.2|WP_050342213.1|3112318_3113485_+|agmatine-deiminase
MRTIHESESSPRADGFRMPAEFEPQRRIWMGWPHRTDTWSFGAKPAQRQYADIARAISEFTPVVMCVNQADYANAKAVFEQDESVTVLEMTTDDAWFRDTGATYVINDAGEVRANHWHFNAYGGFYDGLYFPWDKDEQIALKMAEFSGVRRYRPDSLILEGGSITVDGEGTCVVTDMCLLSPGRNASVSDLEPWSEELRRYMDEQLAKYLNVEKIIWVKDGIDPDETNGHIDDVATFIAPGVMACIWTDDPDYPFYRECHAAFETLSGATDAKGRKLKVYKLPMPVKPLYMTQEACDTIDVDENAEPRVPDEPLIASYMNYLVTNKGIITPQYGDENDALAIETLRRIYDETWGEGSYTVVGVKSDQVVYGGGNIHCITQQEPAPQVG
>NZ_CP012069.2|WP_050342211.1|3111165_3112224_+|putrescine-carbamoyltransferase
MAMPKDFIDSNDFTKEQILAIEDLGLAMKKAIKHDGFYPHLLRNKSLGMIFQQVSTRTRISFETAMTDLGGHAQFFGPGTIQLGGHESLGDTARVMGSLLDILMARVNRHADVRGLAAGSAAPVINGMSEFNHPTQEMGDLMTMLEHLPAGKRVEDCTLAFIGDATQVCVSLMFICSKIGMRFVQYGPKGHQITDGGLQVDDKVDLLAIGKANCEESGGTIVISDDIESIRGADFVYTDVWYGLYDQEEGGESYMDVFYPTYQVTMDMMSLAGPTSKFMHCLPATRGEEVTDEVMDDPVRSLCWVEAENRKHSIRALLAALGDRTPLADENISYSAKRELHDALRKIDELQA
>NZ_CP012069.2|WP_050344624.1|3109704_3110688_-|helix-turn-helix-transcriptional-regulator
MILFFFIYTTALLVICIMALSVCGAAFLVSHSRRYILRSLFFVFYALELSWIFGAEWMAQHVITIDESNYYAIGNPWVAIPMGAAILACFWATALDMVDIHGVRAIVLPTALVMAAQAVVLAALPYGPLRQWLYYSMRQAFLIGCLLYGFHLYRSSSDTAFRQRMVQHKQLFVTILALTCCILLEDVYVILLAPVPDASGSFAGLFLSTRNFSENALMVYLAWYVCREAIRDLSLRYLEPPASQPMDDKGRDLRGHIESRILTFAAHHGLSRREREVLGLVMEGRTNHEVAGTLYLAEGTIKAHVHNIMKKCGCSRREELQRAFWAS
>NZ_CP012069.2|WP_050342210.1|3108740_3109280_-|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MKLRDTLNILQNWDIRGRYVFRKCDLAIVLDESGRTLDQTLARLVKAGVLERPAHGVYLFAHSRNTGPATIEHIARNLRRGELTYESLESALSLYGVISQIPVDRLTLMTTGRSGEYHTPQGVIEFTHTKQPTEAIVPELVGREGHALPLASKRLAYKNLCSVRRNLDLVDEGELHAQD
>NZ_CP012069.2|WP_050342208.1|3107884_3108754_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MPKIDFNAYAAQLARTNGRQTMAPVIEKELLHYEILRAMEEDGLLGGLVFQGGTCLRLCYGASRYSEDLDFAGGFDFDAADLDMLKTCIEHALPRRYLVTVDVREPDTSASLVKRWRIRVDTTPARPDIASQKVSVEVAAIPAHTKHPRMLRLNYEGLPASYEDVVLFAESLEEIMADKLEALACSKLPRYRDIWDLHWLVRQPGIDLDEACALRKRKEADYRESEIFVKEAPRLVGDLATIVEGNEFAKQMRRFLPIDQFERTIARPAFCAALTEGVRELYARCGVHE
>NZ_CP012069.2|WP_050342207.1|3106003_3106945_-|hypothetical-protein
MKRIGRTLAIALSITLMAAAGLAVGRARVARADDYSRPPSSGISEGDIAILSATRTEFEVGPDQQTTLRLQSTLAVDHAVASVAGSGETLPMYDDGNLGAHGDDIAGDGVYSALYTVDCSREDLGGIEITGTITIGSQSLASEPVALYVVAPFTDAELGLMATVDQAISDVMQGEGFDAKPLPDQAAAVKAVLDRLASSDPGIEGYSSPLIVKGSVEYEEGATAISFQYAIGAGIDGGVLLKNPDPNMKGGDAERQASSAERMHTGVEMGTEGGSDVRTAAPSADLPTTLAIGAALAVALGACLLLRLRRGRG
>NZ_CP012069.2|WP_050342205.1|3104642_3105608_+|carbamate-kinase
MSKPYGKPNRVVIALGGNALGNTPEEQIRRVREAAPTLLRVIEQGNEIIITHGNGPQVGMIQKAFTFANQTDPKIPTMDLPECGAMSQGYIGYHLQQAIGAAMHKEYKRWHVATVVTQIEVDPDDPAFQNPTKPIGAFLTKEQADAEMAAHPDMTFVEDSSRGWRRVVASPDPKKIVEYESILNLLDNEFIVIACGGGGIPVVRDYGDKGAYKGVAAVIDKDMGGELLAEDCHADTLVLLTAVDHVAINFGKPDQKELEDLSVGEARAYLEEGQFGKGSMEPKVRAAIRFAESRPGRTCVIGSLERAAEAMAGLSGTRIHA
>NZ_CP012069.2|WP_050342204.1|3103262_3103847_+|hypothetical-protein
MTDSTNLWTGLLNDELYERTNEVGVFLTKMAADLGEATDGAVRAAYHKQSEEDLAGALFPIFQEAQKLQETVSVTHLQQDSHIDANNLYKSHTYVFDIQNETYSFQLFLLVVPPVFPIAMTVDEGVYRDTAHLLNSCGTVDDEKFSVEITSQEGLVECFDILLKSKKLRYLVNSLCKEQGQSYLYDESTEKAFR
>NZ_CP012069.2|WP_083444048.1|3117848_3118580_+|QueT-transporter-family-protein
MIASPGSSQKPPSDARGRVALLTAQRVSRIASIAALYAATTLVCLLFLGSLAWGPIQFRLSEALCVLALLSPDAVPGLALGCAVANIANIAVSGTGMLGMLDVVFGSLATLVGAWCTWRLRRHPRLAVLGPVVANALIVPAYLPLMLKGIGFYTIPFTSISLDDSYALMYLFGLLATGIGEAVVLYVLGLPLWRALLGSPLVRDFAAREDTAGGGRTSIGEPPVLGGGDATGGGTDRHVTERI
>NZ_CP012069.2|WP_050342221.1|3118585_3119845_+|glycosyltransferase
MNPAIVIPSYWTEGDESAEIGRVGAYDHATAVLKPLPELESCLDSLEMVRGVLRVIVLLVASGGCEDAARARVDGICRMHPDLHPLVVGAREAGEIARAVDRVAPGLSGDPISLRGYGAIRNMGLAACAVLGHDVAVFLDDDEVILDEDFLLDATYGLGMETRQGLSIYAKSGYFIDREDSPFAAMDGPRLRDRFWAKREEFNEWMHRALSATRISRSNSICGGCFAITAEAYASVAFDPTITRGEDLDYLLNLRMLGLDVWFDNKWRVRHLPPEMPSRAARFLQDVYRWEYELAKLDRANATIGMRQVRPESLRPYPAIWLSSEVHARIALTALMRVIFGPERLAYLRILLVGRLRARRWARSVSESYFEFQTYWPRIMGSLWQDAPLAKRLLHMGRPTPVTRPQCRDCPPSGETADA
>NZ_CP012069.2|WP_157051606.1|3119846_3121199_+|histidine-kinase
MRRWTSAHFAFLIRGFLFVATAAFLGLLSWGIGTSSLVASMVAGAGLAVIITMTGSVLLAPDDLRSQATERTLRVASATLRHMSGGLTRENAAAVCQLLLAETSAAAISITDTTKTLAYVGDGVLGYTGGTANSPATKKVLKSGRMQTFSNLGEDEWVGTVLDEERGPRELSLPVGIFAPLRVADSIEGTLKLYYRHGREVDRTQLAIARGFGELLSTQLSAYELEAQAELAARAEVKALQAQINPHFLFNTLNTIAALTRTNAVRARDLLREFSVYYRRTLESSESLIPLSEELAQTKRYLKIEKARFGASRIIESEAIELGVEQLLVPGFIVQPLVENAVRHGMRDEGPLHIDVQATTDGDDVLIAVADDGLGMSEEAAKNLLAEPSLNHLASGGKRGAGIAIRNVADRIERFYGRGSGVEIMSKEGAGTAVTLKLMGAAPDAAKIKE
>NZ_CP012069.2|WP_050344625.1|3121305_3122046_+|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein
MNALIVDDEEPARSELRFLLEETGRIDCIEEASNAREAVEALVRRKENVNRRRGIEVLFLDIAMPKTSGMQLAEALHQLKNPPAVVFVTAYSEYALRAFNVDAIDYLMKPVETDRLIHSLDKVEARSKPITHAQSSVERIPVEKGGRKVLIPVSQIHYIEAKDDYSCIYTGSERFLSTVSLAKLEQKLTTHGFFRVHRGYIVNLEHVEDIEVIASGILQLGIKNIPEKKIPVSRRRVVTLKRALGL
>NZ_CP012069.2|WP_050342227.1|3122057_3122513_+|YfcE-family-phosphodiesterase
MRYDIIADTHGYLSDVLLHALEGADVIVHAGDICSARDLHRLEDIAPVKFCIGNNDYGYDYGPFAKRDYRFYSSKLRWQVCHYRERLDLAVCDVAVCGHTHRPLVERDKRYGTLVMNPGSPTHPRASGPSMGRIMAEEGQVLSAEIIQLAS
>NZ_CP012069.2|WP_083444049.1|3122493_3123252_-|phosphatase-PAP2-family-protein
MRSSLCFGVWSQVSTQSKRAHRTFARLVRDNLRTIIVVVAALIFMRLAQEILAGEAVKLDSWAYELVVVYMRRPWLTPVMQSISELALPVVLIVMLLAVEAFAPGRRPAICAGVNLVLVLVLNVVLKQIVHRPRPEGFRLIAETGYSFPSGHSMIAMAFYGLLAWMVWHYERDRFVKYLCMSGFTLVVVAVGLSRIYLGVHYATDVLAGFCVSLMWLGLYTKIFVPLFLPDGTGPQAVDRKPEVSSPSSRAG
>NZ_CP012069.2|WP_050342233.1|3123370_3123688_-|thioredoxin
MSNALTASDFDQLVAGADKPVLVDFWAAWCGPCRALGPVVEEVAEEMSERLDVYKCNVDEESELAQQFQIVSIPTLILFKGGKAVHTMVGSMPKADLIKEIEANL
>NZ_CP012069.2|WP_050342236.1|3123826_3124381_+|hypothetical-protein
MATTRDERRLAFVNKVATEVARLEAAGVVLAGNAFSSVCFLKGELSRQEREGAALLSGADGDALRASLAALGYAPEDWCAAATCLRDGRSLTADTLVRTVVTLDPSTLIICDDAAAAAVRGAYADELSSLPDARQSALEAGWVVPLLGMRAVNLGGFAAALLDQRQKQLMWARLKQLPPLGEPY
>NZ_CP012069.2|WP_050342238.1|3124505_3126197_+|glucose-6-phosphate-isomerase
MANVPAPIDVTQTSEWKALQKHFDKLKESVTLKQLFANDPQRVKKLSFDAAGLHFDLSKNLVTDETLKLLVALAKAIGLEERRSAMFDGVHINTTEDRAVLHTALRRPAREAGTLVVDGQDCVKDVHEVLDRMYAFSQRVRSGEWKGVTGKRIENVISIGIGGSDLGPVMVYEALKPYADGGVQVRYVSNIDPNDMAEKTRDLDPETTLVIVVSKTFTTLETMTNAREAKAWLLEGLKAQGAIDGSDRSLTEAIKRHFVAVSTNLKLVSDFGIDPENAFGFWSWVGGRYSVDAAVGLSLIIAFGPERFSQFLQGFHDIDGYFCKTPLEENVVALMGLVNVWYVNFWGAESHAVLPYDQYLHRFPAYLQQLTMESNGKSTRWDGTPVTTKTGEIFWGEAGTNGQHAFYQLIHQGTRLIPADFIAFANTPNPAKDGEQDVHELFLANFLAQTKALAFGKTAEEVRAEGTAEWMVPARCFAGNRPTTSIFGDTLDARTLGALIALYEHITFVEGSVWGIDSYDQWGVELGKQLAKQITPAFHNDEALATQDESTKALIAYYRAHRR
>NZ_CP012069.2|WP_083444050.1|3126307_3127243_-|AmmeMemoRadiSam-system-radical-SAM-enzyme
MSACTTVPRSPTAAAATATPTATAAAATTRAATTVTCDVCPHACRIPEGGMGRCRARGNVGGRIVATGYGHITSLALDPVEKKPLARWRPGKLLLSAGFYGCNLRCPFCQNWQISQAGEHDVPWQEITPAELVETARGAHRRDGRVVGIAHTYNEPLVVWEYIRDVGTLAHEADLANVLVSSGCARPHIIDALAPLIDAANIDLKSFQARTYERYGGDLDTVRAAIERLAAEPSCHLEVTTLVVPGENDSVQEIEAMAKWLASLDGDITYHLTRFFPNWLMQDRGPTPVKDIRALVEVARRWLPHVYAGNC

Crispr_ID: NZ_CP012069_36

• CRISPR_ID: NZ_CP012069_36
• CRISPR_location: 3135183-3135289
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_36

Consensus_repeat	Method
AGAATGCGCTTTTCCGTGAGCCGC	CRISPRCasFinder

spacers of NZ_CP012069_36

>36.1|3135207|59|NZ_CP012069|CRISPRCasFinder
GCGTCCGGTCTTCTGTGGGGCAGTGGACGCAGTGCGTTTTTCCGTGAGGGCAGCTCCCC

CRISPR arrays and Neighbor proteins around NZ_CP012069_36

CRISPR arrays

The CRISPR arrays of NZ_CP012069_36

>merge|NZ_CP012069|36|3135183-3135289|CRISPRCasFinder
AGAATGCGCTTTTCCGTGAGCCGCGCGTCCGGTCTTCTGTGGGGCAGTGGACGCAGTGCGTTTTTCCGTGAGGGCAGCTCCCCAGAATGCGCTTTTCCGTGAGCCGC

>NZ_CP012069|36|33|3135183-3135289|CRISPRCasFinder
AGAATGCGCTTTTCCGTGAGCCGC	GCGTCCGGTCTTCTGTGGGGCAGTGGACGCAGTGCGTTTTTCCGTGAGGGCAGCTCCCC
AGAATGCGCTTTTCCGTGAGCCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342238.1|3124505_3126197_+|glucose-6-phosphate-isomerase	unknown	unknown	gnl|CDD|234679
NZ_CP012069.2|WP_050342272.1|3148158_3148668_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342233.1|3123370_3123688_-|thioredoxin	unknown	unknown	gnl|CDD|200072
NZ_CP012069.2|WP_050342266.1|3145853_3146363_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342249.1|3133254_3133683_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342268.1|3146577_3147024_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342251.1|3134440_3135100_+|VTT-domain-containing-protein	unknown	unknown	gnl|CDD|182775
NZ_CP012069.2|WP_050342253.1|3137529_3139374_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_050342241.1|3127239_3128676_-|AmmeMemoRadiSam-system-protein-A	unknown	unknown	gnl|CDD|235170
NZ_CP012069.2|WP_050342243.1|3128775_3130602_-|adenine-deaminase	unknown	unknown	gnl|CDD|223933
NZ_CP012069.2|WP_050342256.1|3139640_3139889_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342271.1|3147496_3148159_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083444052.1|3135704_3137540_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP012069.2|WP_050342245.1|3130839_3131865_+|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl|CDD|376556
NZ_CP012069.2|WP_050342260.1|3144883_3145372_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342258.1|3140051_3144884_+|leucine-rich-repeat-protein	unknown	unknown	gnl|CDD|275383
NZ_CP012069.2|WP_050342236.1|3123826_3124381_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342270.1|3147023_3147497_+|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl|CDD|379297
NZ_CP012069.2|WP_050342247.1|3132458_3133076_+|hypothetical-protein	unknown	unknown	gnl|CDD|237284
NZ_CP012069.2|WP_083444050.1|3126307_3127243_-|AmmeMemoRadiSam-system-radical-SAM-enzyme	unknown	unknown	gnl|CDD|275136

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342238.1|3124505_3126197_+|glucose-6-phosphate-isomerase	gnl|CDD|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NZ_CP012069.2|WP_050342233.1|3123370_3123688_-|thioredoxin	gnl|CDD|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	7.8406e-48
NZ_CP012069.2|WP_050342251.1|3134440_3135100_+|VTT-domain-containing-protein	gnl|CDD|182775	PRK10847, PRK10847, DedA family protein.	2.89823e-50
NZ_CP012069.2|WP_050342253.1|3137529_3139374_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.0755e-173
NZ_CP012069.2|WP_050342241.1|3127239_3128676_-|AmmeMemoRadiSam-system-protein-A	gnl|CDD|235170	PRK03881, PRK03881, hypothetical protein; Provisional.	0
NZ_CP012069.2|WP_050342243.1|3128775_3130602_-|adenine-deaminase	gnl|CDD|223933	COG1001, AdeC, Adenine deaminase [Nucleotide transport and metabolism].	0
NZ_CP012069.2|WP_083444052.1|3135704_3137540_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.01777e-151
NZ_CP012069.2|WP_050342245.1|3130839_3131865_+|N-acetylmuramoyl-L-alanine-amidase	gnl|CDD|376556	pfam01510, Amidase_2, N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.	9.68653e-14
NZ_CP012069.2|WP_050342258.1|3140051_3144884_+|leucine-rich-repeat-protein	gnl|CDD|275383	sd00036, LRR_3, leucine-rich repeats. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	9.05477e-42
NZ_CP012069.2|WP_050342247.1|3132458_3133076_+|hypothetical-protein	gnl|CDD|237284	PRK13108, PRK13108, prolipoprotein diacylglyceryl transferase; Reviewed.	0.00819825
NZ_CP012069.2|WP_050342270.1|3147023_3147497_+|carboxypeptidase-regulatory-like-domain-containing-protein	gnl|CDD|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	3.91435e-08
NZ_CP012069.2|WP_083444050.1|3126307_3127243_-|AmmeMemoRadiSam-system-radical-SAM-enzyme	gnl|CDD|275136	TIGR04337, Radical_SAM, AmmeMemoRadiSam system radical SAM enzyme. Members of this protein family are uncharacterized radical SAM enzymes that occur in a prokaryotic three-gene system along with homologs of mammalian proteins Memo (Mediator of ErbB2-driven cell MOtility) and AMMERCR1 (Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis). Among radical SAM enzymes that have been experimentally characterized, the most closely related in sequence include activases of pyruvate formate-lyase and of benzylsuccinate synthase.	5.66431e-74

Protein sequences

>NZ_CP012069.2|WP_050342251.1|3134440_3135100_+|VTT-domain-containing-protein
MDFVNFIVNLLRNPRKSIEAAIEMGPFVSYGFVFLIIFIETGVVFFPFLPGDSLLFASGFFAHGGDGGGFNIFILLGIVWVAAILGDQCNFMIGHFFGRKIVASGRVKAMTPERMEKSQVFLDKWGHLAIFLGRFFPFIRTFVPFIAGMGGMKWHNFVLWNVLGGITWSTLFTLLGYFFGGIEFVKEHFELLVVGIVAVSLVPTVVGLVRSHLKKRSVS
>NZ_CP012069.2|WP_050342249.1|3133254_3133683_+|hypothetical-protein
MDEERYLLRDVTQLPQVHDGRLAGLDVTGGALTLHIDDLHEPNAPSGSCDMVFEGFDDVYSDVNLLVTRFGVGMNVTGRLFYLDDLMVYMERRRLPDLWVLEILARCEKVMIGCWLSALDPEDRGSPAWLSICARSLRYLWS
>NZ_CP012069.2|WP_050342247.1|3132458_3133076_+|hypothetical-protein
MTNKWFRRFMSVFLALVVALNPLDTRSFITKALATAPESAGMSDVEKKATPGLSALGKGVAKALGPLLGALGSGVAEEAEETGSETVGEAIEGTATATEEGAATVEEGATAAEGGAEKGAAEAEAGQAETEQGATEKGAAEDQTKPDTPKVKSTSPNQMQKQVGRRQAPKEVDRVDTGNTASGAQPHIHFKGDYKSLNMDGTWGA
>NZ_CP012069.2|WP_050342245.1|3130839_3131865_+|N-acetylmuramoyl-L-alanine-amidase
MGYRSHAWLRNLIVAVVLVAGVGCAVAFALSPSRSQDTVSDASPAASPDGDAPQPQPVTPEVVENTSDAKKLDQGITFSGPDPAKTEDGAQAGSGTPAPDNVQRGWKWVATDDGSGGNDGGKAVYCDDAGGHLQTGSATIDGVEYHFNETTGALELGAQWIQGEHFNHGTKAVQKYIVLHDTEVAGSPASVVEGWKNSRSGAVAAHFVIGRDGSLVQCGRLNQILHHAGWGGPGDFDSKFGVGSNDGKGNGDDLYGVTPWSGYTSYGMNSYSVGIEMVHLTGQDYPEAQLDKLDQIIRYIDTYFGFQSTIIKHRDWRPSNSDTEPNFDPYFESYQRIRRHH
>NZ_CP012069.2|WP_050342243.1|3128775_3130602_-|adenine-deaminase
MINRFCKMPLWECNDTLVRVAQGQQPAELVIKDAHLVSVDTRELLEHADIAIACGRIAYLGIGGHSAAHCIGKTTEVVDANGLFAAPGLLDSHIHIESSMVGPSEYARAVVPHGTVGIYADPHEVANVCGLDGVRAMWEDAARTPLKTMLTTPSCVPAVTDVEDTGASIDAAQIAESMTWPETCALGEMMNFPGILACEKNALDEVRETLKTDRVVTGHYVTPDIDRGLAAYIASGASCCHESGSVADVLAKLRMGMYAQLRQGSAWLNLPGYLPQLIESGVDMHHCLLCTDDSHPHTIVSDGHMDRVVRDAVALGLDAVVALQLATINVAEYFGVGRDMGSIAPGKCADIVLFEDLRDFRAVRVWIDGSQVAERGQALFDVRPFAWPTFMTSTMNLGGQLCPQSFEFREGEGRPDGSCQVRAMAVSGGDTITQDSVVEVPVRGGKLMADPDHDILKVCVFDRHHADAGTFSHGFATGFGIHGALAQTVSHDAHNLLVMGDNDADMLLAARTLEACGGGEVAVQDGKVLALVELPVCGLMSDGRVEVVSEKVSRIEEAWRTMGCRLPSPFMTMGVMSLACIPVLRQTNRGYVNCVSFQTEPLIVEETA
>NZ_CP012069.2|WP_050342241.1|3127239_3128676_-|AmmeMemoRadiSam-system-protein-A
MAILAAYAVPHPPLIVHAVGHGREEEIQATVAAYREMGRRICELSPETLVISSPHSIMYRDYLHISPGSAASGNFGHFGAPKACHHVRYDEAFVSSLGAAAAADDLAAGTEGEQDPALDHATMVPLHFIEEAYREAGRDMDFRVVRIGISGLSPAAHYRLGTLIQRVADVLGRRVVYVASGDLSHKLTKDGPYGFAPEGPTFDRIVCDAFLSGDFLPLLAMDPRLAERAAECGLRSFQMMAGALDQTEIHPELLSYEGPFGVGYAVAAFTPCGPERGCPKRDYLSVYEKARAREQSGRRASEDPYVRLARLSLETHVRDGGRVRLPDDLPKDLALPDELATTRAGCFVSLKKDGELRGCIGTIAPTRESLAAEICANAVSAAVHDPRFAPVRVDELDELVYDVDVLSPPEPIEGPEQLDVRRYGVIVSTDDGRCGLLLPDLDGVDTVDEQIDIAARKGGIDLARDSWRLERFEVVRHT
>NZ_CP012069.2|WP_083444050.1|3126307_3127243_-|AmmeMemoRadiSam-system-radical-SAM-enzyme
MSACTTVPRSPTAAAATATPTATAAAATTRAATTVTCDVCPHACRIPEGGMGRCRARGNVGGRIVATGYGHITSLALDPVEKKPLARWRPGKLLLSAGFYGCNLRCPFCQNWQISQAGEHDVPWQEITPAELVETARGAHRRDGRVVGIAHTYNEPLVVWEYIRDVGTLAHEADLANVLVSSGCARPHIIDALAPLIDAANIDLKSFQARTYERYGGDLDTVRAAIERLAAEPSCHLEVTTLVVPGENDSVQEIEAMAKWLASLDGDITYHLTRFFPNWLMQDRGPTPVKDIRALVEVARRWLPHVYAGNC
>NZ_CP012069.2|WP_050342238.1|3124505_3126197_+|glucose-6-phosphate-isomerase
MANVPAPIDVTQTSEWKALQKHFDKLKESVTLKQLFANDPQRVKKLSFDAAGLHFDLSKNLVTDETLKLLVALAKAIGLEERRSAMFDGVHINTTEDRAVLHTALRRPAREAGTLVVDGQDCVKDVHEVLDRMYAFSQRVRSGEWKGVTGKRIENVISIGIGGSDLGPVMVYEALKPYADGGVQVRYVSNIDPNDMAEKTRDLDPETTLVIVVSKTFTTLETMTNAREAKAWLLEGLKAQGAIDGSDRSLTEAIKRHFVAVSTNLKLVSDFGIDPENAFGFWSWVGGRYSVDAAVGLSLIIAFGPERFSQFLQGFHDIDGYFCKTPLEENVVALMGLVNVWYVNFWGAESHAVLPYDQYLHRFPAYLQQLTMESNGKSTRWDGTPVTTKTGEIFWGEAGTNGQHAFYQLIHQGTRLIPADFIAFANTPNPAKDGEQDVHELFLANFLAQTKALAFGKTAEEVRAEGTAEWMVPARCFAGNRPTTSIFGDTLDARTLGALIALYEHITFVEGSVWGIDSYDQWGVELGKQLAKQITPAFHNDEALATQDESTKALIAYYRAHRR
>NZ_CP012069.2|WP_050342236.1|3123826_3124381_+|hypothetical-protein
MATTRDERRLAFVNKVATEVARLEAAGVVLAGNAFSSVCFLKGELSRQEREGAALLSGADGDALRASLAALGYAPEDWCAAATCLRDGRSLTADTLVRTVVTLDPSTLIICDDAAAAAVRGAYADELSSLPDARQSALEAGWVVPLLGMRAVNLGGFAAALLDQRQKQLMWARLKQLPPLGEPY
>NZ_CP012069.2|WP_050342233.1|3123370_3123688_-|thioredoxin
MSNALTASDFDQLVAGADKPVLVDFWAAWCGPCRALGPVVEEVAEEMSERLDVYKCNVDEESELAQQFQIVSIPTLILFKGGKAVHTMVGSMPKADLIKEIEANL
>NZ_CP012069.2|WP_083444052.1|3135704_3137540_+|ABC-transporter-ATP-binding-protein
MAAKGDLGLVARYLGRYRRDFALATIFAFAESVLELTIPFQMAYIVDVGIAQAKLDLIYLSGAQMLVTALVAGGCGLGYARASARAAMGFGANLREAEYAHLQGFAFSNLDEFETSSLVTRMTTDVTVVQNALMMGFRPLLRGPIMLVMGLLIACTMSVQLALVFLVTLPVLAVVLAIIVLRVAPLYGVMQGAMDRLNEALQEDLVAIRAIKAYVREDYVAERFERVNELLAKSSTRTFRIAVLNTPIFQLSMGVASVCLLWFGGQMIMAGTLGVGTLTGFMSYVLLIMNSLMMISSVFLLLARAITSIHRICEVLRERPALTSAKDGLTSVPDGGVRFCDVSFKYSANARKDVLEHVSLYFAPGSTVGILGGTGSGKTSLVQLIARLYDASTGVVEVGGHDVRDYDLASLREAVGIVLQKNVLFSGTVRDNLRWGNPDATDEELLEACRVACADEFLERIGGLDGDLGQGGVNVSGGQKQRLCIARTLLKHPKVIVFDDSTSAVDMKTDARIRSGLAALGGMTKVIVAQRVSSVVESDQIVILDDGRVHATGTHAELLMHDHIYQELCASQGVASLHEAVGAAQSALNAGAQAVHPGDGGEDGAEVRHGS
>NZ_CP012069.2|WP_050342253.1|3137529_3139374_+|ABC-transporter-ATP-binding-protein
MAARADAPRAPQDLGRTLRKLTGYLGHARFQLLAVALLVSVSGLANLVGTYMIKPVVNAVGRGDAGGFTSGIALTAGIYALGVVACLGYTQTMVHAAQRIVFDIRRDLLAHIQTLPLSWFDSRRSGDIMSFFTNDVDTVSEALNNSFANMVQALIQTVGTVALLLALNWRLTLITLVCDALIVLYVRFSGRRSKRYFSRQQESLGLLDGYIEEMTSGQKVIKAFNHEGQNLAGFRALNDDLRQTGTSAQAYAATMVPVTVAVSYANYAIVAVVGALMALFGQMDAGSLASYLVFVRQAAMPINQLTQLGNFLLTALAGAERIFEVMELPAETDEGVTHLECVEGEATKVAGVSESCRAWRWRKGDGSCVALAGDVRLEHVNFGYLAGQTILEDLSLWARPGQKIAFVGATGAGKTTITNLINRFYDIRSGSISYDDIDIRAICKPDLRASLGIVLQDTHLFAGTIADNIRFGKLDATDDEVRRAAQIANADSFISRLPKGYDTSISADGASLSQGQRQLISIARAAVADPPVLILDEATSSIDTRTEALIARGMDQLMAGRTVFVIAHRLSTVRNADAIMVLDHGRIVERGTHDGLLARRGEYWQLWTGAKELD
>NZ_CP012069.2|WP_050342256.1|3139640_3139889_+|hypothetical-protein
MSSSTRLPLRSRSLRPWAMRHRCGRYMGLGLDTPLYLICHPLVLAVNYLPRMAVMPMNVIVSAREGVLDREAYLGGAGVGLA
>NZ_CP012069.2|WP_050342258.1|3140051_3144884_+|leucine-rich-repeat-protein
MMRVARSVLSAFLSMALVVGMVPDCAYAKVAAQALHLGASQASPSGAGDAQQASQDDGASSGEPAPADTGEEADGDAELQSAAPEEGFSYRQVSGGVEVTGYAGDATELSIPEELGGSKVVSIANSALSGHTSLRSVEVPGSVGTLGAHSFDGCTSLTSVRLSEGVRRLGALAFAGCSSLASVELPASLESTEGEAPWGAGPFEGSGLASARLAPGSTRVAAGAFRGCSSLASVELPDTVTSVGSYAFARCTSLPAALEVPAGVTSVGDSAYEDCAQATSLSLPPTLSSVGTSAFARCSSLASVEVPGSVGTLGAHSFDGCSSLASVRLSEGVRRLGALAFAGCSSLASVELPASLESTEGEAPWGAGPFEGSGLASARLAPGSTRVAAGAFRGCSSLASVELPDTVTSVGSYAFARCTSLPAALEVPAGVTSVGDSAYEDCAQATSLSLPPTLSSVGTSAFARCSSLASVEVPGSVGTLGAHSFDGCSSLASVRLSEGVRRLGALAFAGCSSLASVELPASLESTEGEAPWGAGPFEGSGLASARLAPGSTRVAAGAFRGCSSLASVELPDTVTSVGSYAFARCTSLPAALEVPAGVTSVGDSAYEDCAQATSLSLPPTLSSVGTSAFARCSSLASVEVPGSVGTLGAHSFDGCSSLASVRLSEGVRRLGALAFAGCSSLASVELPASLESTEGEAPWGAGPFEGSGLASARLAPGSTRVAAGAFRGCSSLASVELPDTVTSVGSYAFARCTSLPAALEVPAGVTSVGDSAYEDCAQATSLSLPPTLSSVGTSAFARCSSLASVEVPGSVGTLGAHSFDGCSSLASVRLSEGVRRLGALAFAGCSSLASVELPASVTSIDDTTFEGCDALTLSCPRGSFAYSWAVEHGLGVSASDGTHALLDPAACSYSARRLDDGLVELTVRWGLAEPSADVSVGAVTLGVPASTDVREVRVDGATADWSLSGRKLYVPTGAPSGSVEVLCEVPAGEASSLSYASVALRSGGAPASEVVGSVADLSSPLSISVPEVTASGTFSVRGNAPAGSRVELRVGGVPAGSATASASGAYEAEVSVSSPVEGWEYAVSASCGGSSARGTVLFDPAAAGVTSFVMRYDGGDHDLLGGDPASYTFLLSSYHGEHPFRFEAAFDVPPERIEAARVVSVKGTERKCMDLAWDGSAGLWVAEGWFDPSDHDYVPGSLSVSYKVRPREVADGLPAPGAAPAPTAARPAGWEDVTVTPERLPDGSVRYTYHSPTLFGDGDGPATITVTRREAEEARQAGAPATVEEAIEQGYEPVGRTYLPVARGKVIGSPGMVGGPYKTSDGSSCYMRTIDGPGGVTNVDLVMFGAGTGLQTWEKYCASKEYMDAVKEVFGRLESPGRAVGVASVVSSAVSFGVQRVRYGHIRGVIGHMDLSDEERASLNQRMDLAEALGAVNVGLSIACVAVAPELGVVLGVFGLVNSFAIGWIDRSIIWDLLWYERRGSRSAARIDPSGSVRDADTGAPIPGARVTLWYRPFEGAEPEPWDASSCGQGNPLVTDDRGSFAWEVPEGWYQVRVEAEGYRPAQSGWLYVPSAAAEGVMVPMARLSPSAAPGSPERVLAPSGPPAALGKAA
>NZ_CP012069.2|WP_050342260.1|3144883_3145372_+|hypothetical-protein
MDNALLALYVWFSLALLFTGCVGSMGDVPARVSELRMTLVFALHAALSLGLSAHIAWRRLRWVPVEGEPIVASQEAGPPYPPNIYRSSGCGWRWTYCGVTYTAEDYTPGDYLFAWEKRTTLWVDPRDPSRLLPSTWGLRLLSYLTFGGVSAYFALRLWGVVP
>NZ_CP012069.2|WP_050342266.1|3145853_3146363_+|hypothetical-protein
MDNALLALYGWFSLALFVIVAVAPLSSSAVAMALWSALSLALSAHIAWRRLHWVPVEGEVIEVRSGASGSGSWSFGWRWSYGGVTHTATDIVGRSFLPPFNRIGEGTRATLWVDPRDPSRLLPPSWRARLTSYLVDVVMGAYGTLYLGARALGLSWGGVGGLVRLLLGG
>NZ_CP012069.2|WP_050342268.1|3146577_3147024_+|hypothetical-protein
MDNVLFYCYLAFMILIPTLSALGGSGYGDSLPPSLLSSTALALSATIAWRRLRWVPVAGEMVGESGYVGYYNVATYAWRYEFCGLAYEASDVVPNLAGLPDTRRHGTVWVDPDHPSRILPPSRRGCLLIYLVFGAIPVYALLRSGELL
>NZ_CP012069.2|WP_050342270.1|3147023_3147497_+|carboxypeptidase-regulatory-like-domain-containing-protein
MDGISAAPQSSPAHTIQRVKRDMYAEGPSPIRADPSGTVVDAATGEPVPGAGVTLWYAPLPGVDPESWDASPWGQENPLATDGGGRFSWEVPEGWWQVRVEAEGYWPAQSEWVRMPAATEPDLQIGLRPASLPQPGGAACADCSVVPGPSARLGRVA
>NZ_CP012069.2|WP_050342271.1|3147496_3148159_+|hypothetical-protein
MDDMLFYGYPFLLLIMMALSALGGGPQCSLALTYVSFVALALALSAHIVWRRLRWVPVAGELVGVYKYPGTRPVAFVRYEFCGRVYESQDSIPLGLGRHGTVWVDPAHPSRILPPSWRFRLLACRLTAALAPLVVSLTAATCAGWVTWRAVGLAPLARARYDGVCRGRPCPRAPPQSRPRDSPPRRGGGKPGATMRTRASSPRLCGSGTPSPAPDPGRAA
>NZ_CP012069.2|WP_050342272.1|3148158_3148668_+|hypothetical-protein
MDNALLALYGWFTLALFVIFAVAPLSSSAVAMALWSALSLALSAHIAWRRLHWVPVEGEVVEVRSGGPGSGSWSFGWRWSYGGVTHTATDIVGQSFLSLFNRIGRGTRATLWVDPRDPSRLLPPSWRARLTSYLVDVVMGVYETLCLGARALGLSWGGVGGLVRLLLGG

Crispr_ID: NZ_CP012069_37

• CRISPR_ID: NZ_CP012069_37
• CRISPR_location: 3151473-3151571
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_37

Consensus_repeat	Method
CGACCCCACCGCACGTGCTACCCCG	CRISPRCasFinder

spacers of NZ_CP012069_37

>37.1|3151498|49|NZ_CP012069|CRISPRCasFinder
ACGCGGTGAACCCCGCCGCGAGCTGCGTGCTCTACACGAGAGCCATGCA

CRISPR arrays and Neighbor proteins around NZ_CP012069_37

CRISPR arrays

The CRISPR arrays of NZ_CP012069_37

>merge|NZ_CP012069|37|3151473-3151571|CRISPRCasFinder
CGACCCCACCGCACGTGCTACCCCGACGCGGTGAACCCCGCCGCGAGCTGCGTGCTCTACACGAGAGCCATGCACGACCCCACCGCACGTGCGACCCCG

>NZ_CP012069|37|34|3151473-3151571|CRISPRCasFinder
CGACCCCACCGCACGTGCTACCCCG	ACGCGGTGAACCCCGCCGCGAGCTGCGTGCTCTACACGAGAGCCATGCA
CGACCCCACCGCACGTGCGACCCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342288.1|3152339_3152618_+|hypothetical-protein	unknown	unknown	gnl|CDD|278862
NZ_CP012069.2|WP_050342284.1|3151653_3152091_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|235142
NZ_CP012069.2|WP_050342266.1|3145853_3146363_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342279.1|3150292_3150793_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342297.1|3158260_3159328_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226459
NZ_CP012069.2|WP_050342268.1|3146577_3147024_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342292.1|3155316_3155577_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342277.1|3149555_3150065_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_083444053.1|3157227_3157548_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl|CDD|224937
NZ_CP012069.2|WP_050342301.1|3163320_3163629_+|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl|CDD|234669
NZ_CP012069.2|WP_050342274.1|3148894_3149338_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342272.1|3148158_3148668_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342271.1|3147496_3148159_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342293.1|3156445_3157267_+|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl|CDD|319818
NZ_CP012069.2|WP_050342294.1|3157548_3157764_-|DUF1778-domain-containing-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342260.1|3144883_3145372_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342290.1|3152735_3155315_+|glycoside-hydrolase-family-3-C-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|185053
NZ_CP012069.2|WP_050342258.1|3140051_3144884_+|leucine-rich-repeat-protein	unknown	unknown	gnl|CDD|275383
NZ_CP012069.2|WP_050342270.1|3147023_3147497_+|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl|CDD|379297
NZ_CP012069.2|WP_062393172.1|3160561_3163216_+|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl|CDD|235505

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342284.1|3151653_3152091_-|GNAT-family-N-acetyltransferase	gnl|CDD|235142	PRK03624, PRK03624, putative acetyltransferase; Provisional.	2.77665e-22
NZ_CP012069.2|WP_050342293.1|3156445_3157267_+|Cof-type-HAD-IIB-family-hydrolase	gnl|CDD|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.76478e-51
NZ_CP012069.2|WP_050342297.1|3158260_3159328_+|AAA-family-ATPase	gnl|CDD|226459	COG3950, COG3950, Predicted ATP-binding protein involved in virulence [General function prediction only].	1.40945e-45
NZ_CP012069.2|WP_050342290.1|3152735_3155315_+|glycoside-hydrolase-family-3-C-terminal-domain-containing-protein	gnl|CDD|185053	PRK15098, PRK15098, beta-glucosidase BglX.	5.2924e-75
NZ_CP012069.2|WP_050342258.1|3140051_3144884_+|leucine-rich-repeat-protein	gnl|CDD|275383	sd00036, LRR_3, leucine-rich repeats. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	9.05477e-42
NZ_CP012069.2|WP_050342288.1|3152339_3152618_+|hypothetical-protein	gnl|CDD|278862	pfam00455, DeoRC, DeoR C terminal sensor domain. The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR).	5.99278e-11
NZ_CP012069.2|WP_050342270.1|3147023_3147497_+|carboxypeptidase-regulatory-like-domain-containing-protein	gnl|CDD|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	3.91435e-08
NZ_CP012069.2|WP_083444053.1|3157227_3157548_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl|CDD|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	1.53901e-16
NZ_CP012069.2|WP_062393172.1|3160561_3163216_+|DNA-polymerase-III-subunit-gamma/tau	gnl|CDD|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	1.20868e-165
NZ_CP012069.2|WP_050342301.1|3163320_3163629_+|YbaB/EbfC-family-nucleoid-associated-protein	gnl|CDD|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	4.30209e-37

Protein sequences

>NZ_CP012069.2|WP_050342279.1|3150292_3150793_+|hypothetical-protein
MDNVLFALYGWFSLALLFVGCVGSIGGAPPRVSSLRMVLVCALHVALSLALSAHIAWRRLHWVPVEGESIATSQEESRSYPPPPYRSSGCGWRWTYGGVTYTAEDYIPFNIPDKYCCVSGKRTIVWVDPRDPSRLLPPSWRDRLFLYLFFGGMSAYMALRLGALTL
>NZ_CP012069.2|WP_050342277.1|3149555_3150065_+|hypothetical-protein
MDNALLALYGWFTLALFVIVAVAPLSSSAVAMALWSALSLALSAHIAWRRLHWVPVEGEVVEVRSGGPGSGSWSFGWRWSYGGVTHTATDIVGQSFLSLFNRIGRGTRATLWVDPRDPSRLLPPSWRARLTSYLVDVVMGAYGTLYLGARALGFSWGGVGGLVRLLLGG
>NZ_CP012069.2|WP_050342274.1|3148894_3149338_+|hypothetical-protein
MDNALFYCYLAFMFLIPTLSALGGSGHGDSLTPSLLSSTALALSAHIVWRRLRWVPVAGELVGEYRYPGTRPAAFVRYEFCGRVYESQDSIPLGLGRHGTVWVDPAHPFRILPPSWRFRLLACRLTAALAPLVVSLTAAICAGWVTW
>NZ_CP012069.2|WP_050342272.1|3148158_3148668_+|hypothetical-protein
MDNALLALYGWFTLALFVIFAVAPLSSSAVAMALWSALSLALSAHIAWRRLHWVPVEGEVVEVRSGGPGSGSWSFGWRWSYGGVTHTATDIVGQSFLSLFNRIGRGTRATLWVDPRDPSRLLPPSWRARLTSYLVDVVMGVYETLCLGARALGLSWGGVGGLVRLLLGG
>NZ_CP012069.2|WP_050342271.1|3147496_3148159_+|hypothetical-protein
MDDMLFYGYPFLLLIMMALSALGGGPQCSLALTYVSFVALALALSAHIVWRRLRWVPVAGELVGVYKYPGTRPVAFVRYEFCGRVYESQDSIPLGLGRHGTVWVDPAHPSRILPPSWRFRLLACRLTAALAPLVVSLTAATCAGWVTWRAVGLAPLARARYDGVCRGRPCPRAPPQSRPRDSPPRRGGGKPGATMRTRASSPRLCGSGTPSPAPDPGRAA
>NZ_CP012069.2|WP_050342270.1|3147023_3147497_+|carboxypeptidase-regulatory-like-domain-containing-protein
MDGISAAPQSSPAHTIQRVKRDMYAEGPSPIRADPSGTVVDAATGEPVPGAGVTLWYAPLPGVDPESWDASPWGQENPLATDGGGRFSWEVPEGWWQVRVEAEGYWPAQSEWVRMPAATEPDLQIGLRPASLPQPGGAACADCSVVPGPSARLGRVA
>NZ_CP012069.2|WP_050342268.1|3146577_3147024_+|hypothetical-protein
MDNVLFYCYLAFMILIPTLSALGGSGYGDSLPPSLLSSTALALSATIAWRRLRWVPVAGEMVGESGYVGYYNVATYAWRYEFCGLAYEASDVVPNLAGLPDTRRHGTVWVDPDHPSRILPPSRRGCLLIYLVFGAIPVYALLRSGELL
>NZ_CP012069.2|WP_050342266.1|3145853_3146363_+|hypothetical-protein
MDNALLALYGWFSLALFVIVAVAPLSSSAVAMALWSALSLALSAHIAWRRLHWVPVEGEVIEVRSGASGSGSWSFGWRWSYGGVTHTATDIVGRSFLPPFNRIGEGTRATLWVDPRDPSRLLPPSWRARLTSYLVDVVMGAYGTLYLGARALGLSWGGVGGLVRLLLGG
>NZ_CP012069.2|WP_050342260.1|3144883_3145372_+|hypothetical-protein
MDNALLALYVWFSLALLFTGCVGSMGDVPARVSELRMTLVFALHAALSLGLSAHIAWRRLRWVPVEGEPIVASQEAGPPYPPNIYRSSGCGWRWTYCGVTYTAEDYTPGDYLFAWEKRTTLWVDPRDPSRLLPSTWGLRLLSYLTFGGVSAYFALRLWGVVP
>NZ_CP012069.2|WP_050342258.1|3140051_3144884_+|leucine-rich-repeat-protein
MMRVARSVLSAFLSMALVVGMVPDCAYAKVAAQALHLGASQASPSGAGDAQQASQDDGASSGEPAPADTGEEADGDAELQSAAPEEGFSYRQVSGGVEVTGYAGDATELSIPEELGGSKVVSIANSALSGHTSLRSVEVPGSVGTLGAHSFDGCTSLTSVRLSEGVRRLGALAFAGCSSLASVELPASLESTEGEAPWGAGPFEGSGLASARLAPGSTRVAAGAFRGCSSLASVELPDTVTSVGSYAFARCTSLPAALEVPAGVTSVGDSAYEDCAQATSLSLPPTLSSVGTSAFARCSSLASVEVPGSVGTLGAHSFDGCSSLASVRLSEGVRRLGALAFAGCSSLASVELPASLESTEGEAPWGAGPFEGSGLASARLAPGSTRVAAGAFRGCSSLASVELPDTVTSVGSYAFARCTSLPAALEVPAGVTSVGDSAYEDCAQATSLSLPPTLSSVGTSAFARCSSLASVEVPGSVGTLGAHSFDGCSSLASVRLSEGVRRLGALAFAGCSSLASVELPASLESTEGEAPWGAGPFEGSGLASARLAPGSTRVAAGAFRGCSSLASVELPDTVTSVGSYAFARCTSLPAALEVPAGVTSVGDSAYEDCAQATSLSLPPTLSSVGTSAFARCSSLASVEVPGSVGTLGAHSFDGCSSLASVRLSEGVRRLGALAFAGCSSLASVELPASLESTEGEAPWGAGPFEGSGLASARLAPGSTRVAAGAFRGCSSLASVELPDTVTSVGSYAFARCTSLPAALEVPAGVTSVGDSAYEDCAQATSLSLPPTLSSVGTSAFARCSSLASVEVPGSVGTLGAHSFDGCSSLASVRLSEGVRRLGALAFAGCSSLASVELPASVTSIDDTTFEGCDALTLSCPRGSFAYSWAVEHGLGVSASDGTHALLDPAACSYSARRLDDGLVELTVRWGLAEPSADVSVGAVTLGVPASTDVREVRVDGATADWSLSGRKLYVPTGAPSGSVEVLCEVPAGEASSLSYASVALRSGGAPASEVVGSVADLSSPLSISVPEVTASGTFSVRGNAPAGSRVELRVGGVPAGSATASASGAYEAEVSVSSPVEGWEYAVSASCGGSSARGTVLFDPAAAGVTSFVMRYDGGDHDLLGGDPASYTFLLSSYHGEHPFRFEAAFDVPPERIEAARVVSVKGTERKCMDLAWDGSAGLWVAEGWFDPSDHDYVPGSLSVSYKVRPREVADGLPAPGAAPAPTAARPAGWEDVTVTPERLPDGSVRYTYHSPTLFGDGDGPATITVTRREAEEARQAGAPATVEEAIEQGYEPVGRTYLPVARGKVIGSPGMVGGPYKTSDGSSCYMRTIDGPGGVTNVDLVMFGAGTGLQTWEKYCASKEYMDAVKEVFGRLESPGRAVGVASVVSSAVSFGVQRVRYGHIRGVIGHMDLSDEERASLNQRMDLAEALGAVNVGLSIACVAVAPELGVVLGVFGLVNSFAIGWIDRSIIWDLLWYERRGSRSAARIDPSGSVRDADTGAPIPGARVTLWYRPFEGAEPEPWDASSCGQGNPLVTDDRGSFAWEVPEGWYQVRVEAEGYRPAQSGWLYVPSAAAEGVMVPMARLSPSAAPGSPERVLAPSGPPAALGKAA
>NZ_CP012069.2|WP_050342284.1|3151653_3152091_-|GNAT-family-N-acetyltransferase
MRIRRMTIDDYEGVRELWMSCSGMGLNNLDDSRDGIERFLARNPDTCFVAEDGRVIGAILVGHDGRRGYVYHTSVDPELRHRNIGTQLVEASLSALRALKINKVALVAFGRNEGGNLFWERQGFSVRDDLVYRDRALTHMVRTDT
>NZ_CP012069.2|WP_050342288.1|3152339_3152618_+|hypothetical-protein
MADRLDRVFLVRQRHSVEPRRDIATKVAELIGGREIIIVDASTTVLEALRTVGDKSNLTVVINSSKICDGSIDVSFYLISTGGIYRWESLSF
>NZ_CP012069.2|WP_050342290.1|3152735_3155315_+|glycoside-hydrolase-family-3-C-terminal-domain-containing-protein
MGLRHHNIIDKMDLEQKCALLSGATAFGTRAYPSLGIPELQFSDGPHGMRHQDPNAANHLGIGGSIPATCFPTAVTVANSWDPALAEELGRALGEEAVDQGVNVVLGLGLCIKRSPLCGRNFEYLSEDPLLAGKMAAGYVRGIQSSGVSACPKHFAANSQETRRQASDSVLDERTLREIYLFAFETVVREARPKTIMTSYNKVNGSYANENPHLLRDILRGEWGFEGAIVTDWGGSNDHVAGVAAGSTFEMPAPGLDSVRQLVKAVRAGELAEADVDARVDEAIELALSTAPAVKVAAGRQFDVDAHHELARRIAAEGIVLLKNEPASADKGQPADAGRPLLPLLPRTKVALIGDFAQNPRYQGAGSSLVNCTRLDTIVDAIGTSELKVLGFERGFDRTDSVDDATDARLRNAAVALAQNAEVVLVCLGLDELAESEGLDRADMRLNQNQVKLLHALSEANGNVVVLLFAGSAVETDWAADARSILYLALGGQAGASAAVDVLMGKVNPSGKLAETWAKRLADTPTYDNFPSDGPVATYREGIYVGYRYYQKASVPVAYPFGHGLSYTSFAFKDIELSEMNEVTSTSVSFDVSNVGDVSGTEVAQLYVGKLRSKVFRPLRELKGFAKVLLEPGETRRVTIDLDERAFRYFNARTGSWEVEGGLYAIEVGTSSEDIRLSARVNVAGTHAQAPYEGLDLTPYETGRVRQVDDAHFAALLGRDVPDERFRMDRNVCFRDVGKSRSPLFWAIGALLRSLRRRSRKSGTPDLSIEFIYNMPMRALAKNAGQFVSMGLVDAIVRELKGWGLAGVLPAALVGFQTGSVGLFALVWLLWFSLPLTWEFVLNRILNTVGERRLARKGS
>NZ_CP012069.2|WP_050342292.1|3155316_3155577_+|hypothetical-protein
MALRDWTERHRGFWEFIKFNVLGNVSMIVRLALMWVGYVLREKVVEVVRHGPLSEPGASLDAPEAPDELKATEPCADGSPVLAQSP
>NZ_CP012069.2|WP_050342293.1|3156445_3157267_+|Cof-type-HAD-IIB-family-hydrolase
MPSRPKLLALDMDGTLLNSQKRISPRTIAALYGLAHSGVVITLSTGRGLAEIADYRDELSWLRYASLDGGALVYNLEAKRPIDALPIPDTLVLSCIRTGRREGVMVHMSTTTGSVVEHGYVERSDEFGVGIYQPMFDRRCERVNDIARYVQDHPCTVVKIDLFHLDSASRERTFGRLSVGSSLSLKRAEATSVECTPVGVNKATGLQKICELLDIGMGEVVAIGDADNDMDILGVVGTSVAMGNASERIRMACDVVVADCDHDGIVEAIERLF
>NZ_CP012069.2|WP_083444053.1|3157227_3157548_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MAYHVEYTDVALKQLKRMDRFDARLIVSWIGKNLEGCRDPRVRGKGLTANRSREWRYRIGNYRVLCVIRDDRLVVEVFSVGHARCAWKAQVPLAQNSRSIASTIPS
>NZ_CP012069.2|WP_050342294.1|3157548_3157764_-|DUF1778-domain-containing-protein
MSTMTMRVSDEDAAVVRKYAKFEGKTISDFIRNAVFERIEDQEDLTALRIAIAEDDGIRHTHEQVLSELEL
>NZ_CP012069.2|WP_050342297.1|3158260_3159328_+|AAA-family-ATPase
MYLNSLELRNFRKFEELHIGFDRQLTVLVGDNGYGKSAVVDAAAIALGTFFMHIPQASQRSIRNTDARVVSRAVGSTIERRPQFPVIVRADGCAYGRSLSWQRELRRDTGRTTWGNAREMVELSERVHECLSSGDIPSDLGECGEGGVLPLPIISYYGTGRLWAQSKNEEPRTSLREAAYASSLLPRADDGSLMRWLRKMTYQQLQKGEPVPELQAVRRAAEECLRRIIQADNVHVFFDVQSNDLCIEIYGDTATSLPLHQLSDGYRTTLGMVADIAYRMAQLNPHYGSDAIERTHGVVLIDEVDLHLHPKWQARILGDLTGIFPGVQFIVTTHSPAVIASVKREKLRSFTEGES
>NZ_CP012069.2|WP_062393172.1|3160561_3163216_+|DNA-polymerase-III-subunit-gamma/tau
MESLYRKYRPKTFEDVVGQQHVVSTLEHAVLEGRTSHAYLFCGPRGTGKTTMARILAKALMCERGAGQLPDGTCENCQLIAAGEHPDVYELDAASRTGVDNVREEIIGRVSFAPVRGSYKVYIIDEVHMLTTAAFNALLKTLEEPPEHIVFVLCTTDPQKVPETILSRVQRFDFHAIGASDILGQLKRVCDAEGFSYDEAALELVVRHARGGMRDALSALEQLSTFGGGSVSLDAARDLLGEVSSSMLTELTGALARRDVPTVFARIGELVESGRDLLQLARELSAHLRDVYVASVVGEGASTLPVAGDELRQLKDEALAFGAPDRVARALAVMSEVSSEMRVATNQRLALEVALTRIARPKSDLTLDSLAERVAQLEKTVEALAAGSASVPMSTTPASSLTAPAPAPTAPAPTSPDPTPQASARQTISAPQVAPAPVHAERPEPQAPQPPTLEQRTQSTSQEPQQVPASVARQAPQELLTSKEAPLASPAQPAPQQRSSEGASQSDQTTGAGAAQQPQPPDAAVQPRKETAPTTPAVTPATPAVTPATPAVTPAAPAITDGGELQRRWRQVVDGLVRTDPPRGSLLAASTALEDDGHRLLINLPKGSSFVTKMLDRKDVRATVEAAVRQAFGERALVYAESSLVGADIARSRAKAPAPTPARGTMVTPQPLSASQGQATPQVVSSVVTQRGHAPAPQPAMSHAAAPATAPQTEPPVEEVPLESYYDMPWDEPSAYEDEPMAPVGEASLAAEPQVASRAVPGPEPVRQTSQQVEPRTAVVFEAQAANTAESKPKPDPKPKAKTAAKTEPKQKPESDPKPKPDPKPKSKAEPKPRSKPKGSQSAPKRADGMPQDMNELLAMLTEVFGDGVEASVEKLQDSAVEQN
>NZ_CP012069.2|WP_050342301.1|3163320_3163629_+|YbaB/EbfC-family-nucleoid-associated-protein
MDMQQMMRQAQKMQKQLADAQDRLADIEVSASAGGGMVKVIGTADMQITSITIDPDALDPEDIEIIQDTIVAAVNECLSSAQEAANQQLGAVTGGMNIPGLF

Crispr_ID: NZ_CP012069_38

• CRISPR_ID: NZ_CP012069_38
• CRISPR_location: 3196134-3196303
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP012069_38

Consensus_repeat	Method
GCCGAGGAAAGTTGCGGGAAAGTTAG	PILER-CR
GTCGAGGAAAGTTGCGGGAAAGTT	CRISPRCasFinder

spacers of NZ_CP012069_38

>38.1|3196160|46|NZ_CP012069|PILER-CR
CGTCCCGGAGTCTGCGGCCGAGCGTGTCGAGGCACCCTCTGCGGTC
>38.2|3196232|50|NZ_CP012069|PILER-CR
AATCCTTACACCTCGGATCGTCTACCTGCGGAAATCCAATACAATGACGC
>38.3|3196158|44|NZ_CP012069|CRISPRCasFinder
AGCGTCCCGGAGTCTGCGGCCGAGCGTGTCGAGGCACCCTCTGC
>38.4|3196226|52|NZ_CP012069|CRISPRCasFinder
GGAATCCTTACACCTCGGATCGTCTACCTGCGGAAATCCAATACAATGACGC

CRISPR arrays and Neighbor proteins around NZ_CP012069_38

CRISPR arrays

The CRISPR arrays of NZ_CP012069_38

>merge|NZ_CP012069|38|3196134-3196303|PILER-CR,CRISPRCasFinder
GTCGAGGAAAGTTGCGGGAAAGTTAGCGTCCCGGAGTCTGCGGCCGAGCGTGTCGAGGCACCCTCTGCGGTCAGGAAAGTTGCGGGAAAGTTGGAATCCTTACACCTCGGATCGTCTACCTGCGGAAATCCAATACAATGACGCGCTGGGGAAAGTTGCGGGAAAGTTAG

>NZ_CP012069|38|6|3196134-3196303|PILER-CR
GTCGAGGAAAGTTGCGGGAAAGTTAG	CGTCCCGGAGTCTGCGGCCGAGCGTGTCGAGGCACCCTCTGCGGTC
AGGAAAGTTGCGGGAAAGTTGGAATC	CTTACACCTCGGATCGTCTACCTGCGGAAATCCAATACAATGACGCGCTG
GGGAAAGTTGCGGGAAAGTTAG

>NZ_CP012069|38|35|3196134-3196301|CRISPRCasFinder
GTCGAGGAAAGTTGCGGGAAAGTT	AGCGTCCCGGAGTCTGCGGCCGAGCGTGTCGAGGCACCCTCTGC
GGTCAGGAAAGTTGCGGGAAAGTT	GGAATCCTTACACCTCGGATCGTCTACCTGCGGAAATCCAATACAATGACGC
GCTGGGGAAAGTTGCGGGAAAGTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342350.1|3198878_3199520_-|Fic-family-protein	unknown	unknown	gnl|CDD|225095
NZ_CP012069.2|WP_050342366.1|3207312_3208437_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|379062
NZ_CP012069.2|WP_050342358.1|3203648_3204062_+|DUF4279-domain-containing-protein	unknown	unknown	gnl|CDD|372913
NZ_CP012069.2|WP_050342367.1|3208539_3209181_-|Type-1-glutamine-amidotransferase-like-domain-containing-protein	unknown	unknown	gnl|CDD|225877
NZ_CP012069.2|WP_050342352.1|3199516_3199744_-|hypothetical-protein	unknown	unknown	gnl|CDD|181296
NZ_CP012069.2|WP_050342344.1|3194700_3194955_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	unknown	unknown	gnl|CDD|274102
NZ_CP012069.2|WP_083444058.1|3194495_3194708_-|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family	unknown	unknown	gnl|CDD|379750
NZ_CP012069.2|WP_157051567.1|3198122_3198266_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_157051568.1|3204734_3205973_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342362.1|3204063_3204576_+|DUF4279-domain-containing-protein	unknown	unknown	gnl|CDD|372913
NZ_CP012069.2|WP_050344632.1|3188175_3188793_+|uracil-DNA-glycosylase	unknown	unknown	gnl|CDD|381680
NZ_CP012069.2|WP_050342346.1|3195538_3196099_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342354.1|3201466_3202528_-|Fic-family-protein	unknown	unknown	gnl|CDD|225718
NZ_CP012069.2|WP_050344633.1|3192025_3194467_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl|CDD|236585
NZ_CP012069.2|WP_157051566.1|3190758_3191508_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342336.1|3185345_3186959_+|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase	unknown	unknown	gnl|CDD|182554
NZ_CP012069.2|WP_050344631.1|3186983_3188162_+|alanine-racemase	unknown	unknown	gnl|CDD|143481
NZ_CP012069.2|WP_083444057.1|3184733_3185333_+|holo-ACP-synthase	unknown	unknown	gnl|CDD|234610
NZ_CP012069.2|WP_083444119.1|3199929_3200886_-|NADAR-family-protein	unknown	unknown	gnl|CDD|271319
NZ_CP012069.2|WP_050342338.1|3188794_3189304_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl|CDD|376771

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342350.1|3198878_3199520_-|Fic-family-protein	gnl|CDD|225095	COG2184, Fic, Protein involved in cell division [Cell division and chromosome partitioning].	9.79449e-37
NZ_CP012069.2|WP_050342358.1|3203648_3204062_+|DUF4279-domain-containing-protein	gnl|CDD|372913	pfam14106, DUF4279, Domain of unknown function (DUF4279). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	3.68076e-09
NZ_CP012069.2|WP_050342367.1|3208539_3209181_-|Type-1-glutamine-amidotransferase-like-domain-containing-protein	gnl|CDD|225877	COG3340, PepE, Peptidase E [Amino acid transport and metabolism].	8.47277e-55
NZ_CP012069.2|WP_050342352.1|3199516_3199744_-|hypothetical-protein	gnl|CDD|181296	PRK08215, PRK08215, RNA polymerase sporulation sigma factor SigG.	0.00310385
NZ_CP012069.2|WP_050342366.1|3207312_3208437_+|AAA-family-ATPase	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	2.31785e-08
NZ_CP012069.2|WP_083444058.1|3194495_3194708_-|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family	gnl|CDD|379750	pfam15738, YafQ_toxin, Bacterial toxin of type II toxin-antitoxin system, YafQ. YafQ is a family of bacterial toxin ribonucleases of type II toxin-antitoxin systems. The E.coli gene is expressed from the dinB operon. The cognate antitoxin for the E. coli protein is DinJ, in family RelB_antitoxin, pfam02604.	1.04546e-15
NZ_CP012069.2|WP_050342362.1|3204063_3204576_+|DUF4279-domain-containing-protein	gnl|CDD|372913	pfam14106, DUF4279, Domain of unknown function (DUF4279). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	4.07787e-07
NZ_CP012069.2|WP_050344632.1|3188175_3188793_+|uracil-DNA-glycosylase	gnl|CDD|381680	cd10030, UDG-F4_TTUDGA_SPO1dp_like, Uracil DNA glycosylase family 4, includes Thermotoga maritima TTUDGA, Bacillus phage SPO1 DNA polymerase, and similar proteins. Uracil DNA glycosylase family 4 includes Thermotoga maritima TTUDGA, a robust uracil DNA glycosylase that shares narrow substrate specificity and high catalytic efficiency with family 1, acting on double-stranded and single-stranded uracil-containing DNA. Members of this family possess four conserved cysteine residues required to coordinate the [4Fe-4S] iron-sulfur cluster. This family also includes the N-terminal domain of Bacillus phage SPO1 DNA polymerase. Bacteriophage SPO1 is one of a group of large, lytic, tailed bacteriophages of Bacillus subtilis, and contains hydroxymethyluracil (hmUra) in place of thymine in their DNA. It has been speculated that this UDG domain may help discriminate between hmUra containing SPO1 DNA and thymine-containing host DNA. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.	5.00336e-83
NZ_CP012069.2|WP_050342344.1|3194700_3194955_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	gnl|CDD|274102	TIGR02384, Putative_antitoxin_RelB, addiction module antitoxin, RelB/DinJ family. Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other].	9.99754e-17
NZ_CP012069.2|WP_050342354.1|3201466_3202528_-|Fic-family-protein	gnl|CDD|225718	COG3177, COG3177, Fic family protein [Function unknown].	5.05947e-20
NZ_CP012069.2|WP_050344633.1|3192025_3194467_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl|CDD|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	6.96114e-156
NZ_CP012069.2|WP_050342336.1|3185345_3186959_+|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase	gnl|CDD|182554	PRK10565, PRK10565, putative carbohydrate kinase; Provisional.	8.51169e-53
NZ_CP012069.2|WP_050344631.1|3186983_3188162_+|alanine-racemase	gnl|CDD|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	2.00899e-162
NZ_CP012069.2|WP_083444057.1|3184733_3185333_+|holo-ACP-synthase	gnl|CDD|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	2.67765e-40
NZ_CP012069.2|WP_083444119.1|3199929_3200886_-|NADAR-family-protein	gnl|CDD|271319	cd15457, NADAR, Escherichia coli swarming motility protein YbiA and related proteins. This family of uncharacterized domains was initially classified as Domain of Unknown Function (DUF1768). It contains members such as the E. coli swarming motility protein YbiA. Mutations in YbiA cause defects in Escherichia coli swarming, but not necessarily in motility. More recently, this family has been predicted to be involved in NAD-utilizing pathways, likely to act on ADP-ribose derivatives, and has been named the NADAR (NAD and ADP-ribose) superfamily.	7.04823e-59
NZ_CP012069.2|WP_050342338.1|3188794_3189304_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl|CDD|376771	pfam02367, TsaE, Threonylcarbamoyl adenosine biosynthesis protein TsaE. This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).	9.71663e-55

Protein sequences

>NZ_CP012069.2|WP_050342346.1|3195538_3196099_+|hypothetical-protein
MKCANESIRERGDGRWQAHFYYKNGDRWKVDPRSFEATSKRAARRRVDEIKEGLERAAQAEGSEGRASLSEENMTTEGFLRRLVGGLVSFGQMERTTAAGYRASAEPASGHLAGKRVDELTGEMILDWQDRLPHLCGSRHPRSQEGGAPGTQGEGLPALDAVGLTEGGRNVEGKLKSLTYCVKTHI
>NZ_CP012069.2|WP_050342344.1|3194700_3194955_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin
MSEARLSIRTDSALKEQARRLYESMGLDLTTAVNMFLRQSVVDHGMPFKPTAESPEDINARREDRMGEGHTFATVDDMMDYLDA
>NZ_CP012069.2|WP_083444058.1|3194495_3194708_-|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family
MLKSIRVLPQFERDVKRLKKKHFPLDKLRSAVSAIFKDSRDELRRLRDHELKGNWLGYRELHIERNWLLT
>NZ_CP012069.2|WP_050344633.1|3192025_3194467_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MLACAVARVTSASAQDNTATTAIDVLATGDHLCCRRANVELTATALETLAKARIAMADVDQVLVGRGPGSFTGVRIGIATAKGLACGLATTLLGASTLDAVAWTAWQAGQRGRLAVVGDAMRKEVYPGVYLLDERGAHRTFEVECVRTVNAAIDELKARSDAEQLVLSGDGLKKYRTAFEGAGLTRMLDESLWHPTGEGLIRASQAPDFRPALGDGDPALVLPVYTRLSDAEEGERARLGLKASPSVRVTGVDEALAGRHLQLRPMLPADLDAVVALDAATYEGSAHTPWTRTMFASELTQPQRSWWVAHDQGRVIGFAGGRLAGADFEVLDVVVSADHRRRHVASRLVARIAYDGQAFGASTISLEVDEHNAAGQALYGSLGFVKVGERPGYFGPDAKGKSHTALILQAKLPLQADAKLMAQLPEPSASIRPWPIVPAPRNAASRQKIEAAGDLVLAIESSCDETAMAVIDSRGTICANVVATSVDFHARFGGVVPEIASRKHVEAIVGVFEEVMAQAGRHFGCDTLAASDLSCVGVTAGPGLVGALVVGIAFAKGLCAATGLPFTAVNHLEGHLLANLFETPDLRPPFVASLVSGGNTMLVHVRAWGDYQILGATIDDAVGEAFDKVAKALGLGYPGGPVISRLAARGNRKAIHFPRAMMHSNDYRFSLSGLKTAVITYIEGEGRAGRAINLPDLAASFEAAVIDVQVAKAVAAVEETGVSDFCIGGGVAANPELRAEYKREFGRRGVRVTVPPMVVCGDNAAMMALAALRNWRAGVLFSLTQDAEPNAKLGCWSSSELPVIGPGWPEKPS
>NZ_CP012069.2|WP_157051566.1|3190758_3191508_+|hypothetical-protein
MSYRYIKVPHISVPGKRRGQTRWAVWHHLRDDDDATIRLNGVRVTSFERTAFDCLRFLPFDQALAVADSALRIRNADIPWLIHSVCGYWPGYLNAQHARQVAHHANGLAENGGESMARAAMIELGYMLPELQAVVPNPLDGGTYRLDFLWRLADGRVVAGEYDGRGKYLNGHDGVPREGDEALRGAVDKMAKERLRESRLTLAMGVMRFSPKQLRSRPYFCQLMDSFGIPRVREPQEIEARARIPRWTL
>NZ_CP012069.2|WP_050342338.1|3188794_3189304_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MTVEFVTSSQEETIALGCTLGSLLREGDVLVLTGDLGAGKTQLTKGIARGMGVSGDVTSPTFTIEMVYEGERMPLYHFDLYRLVDVGELEDIGLYDVLGGDGPCVIEWGERFVDEIGLERVDVLISRLNGEGEGEAGAGIEPLRRIRLTAHDARGEDLLRALEKSTDVE
>NZ_CP012069.2|WP_050344632.1|3188175_3188793_+|uracil-DNA-glycosylase
MPAIHIPGHDRPKPGEVSLDEIRAVMGDCHLCGLGETRTNLVFGVGNPHARVMFIGEGPGRNEDLQGEPFVGAAGHKLDSLLSIAGLTRDEVYIANVIKCRPPGNRNPRPEEIEACAPFLREQVRSVWPDVIVCLGNFASQWLLKTEKGVTKLRGALYQVGHFVVCPTFHPAACIYHSDWQPQLESDLAMVGAWLLANPPSTTGV
>NZ_CP012069.2|WP_050344631.1|3186983_3188162_+|alanine-racemase
MSGRDVLKNCPLDRWAWVEIDLGALRANVRTFKALLEPRTKLMCAVKADAYGHGAVECAKAMYAAGANQFAVATVAEGVELRRAGISWPILVLCEPPLDAIDTLLAHDLMPSIYTSDFAFSLGERAVALGKVGRYHLAIDTGMTRIGVLPDDVVELRHLIDFHRGLECAGTFTHFATADVIGDWDFKQQSSRFSRAIAALEAAGLDHGLVHCDNTPGTVLHPELHNDMCRVGIGLYGLHPSATTEPRVALRPVMSVRARVTRAIYPAVGEGVGYGLTYRVPTPNIQIATVPIGYADGLARVLSNHMDVLVNGVRVRQVGRICMDQFMFAVDTSRRSLGSVKTVAPVECGDVVTILGTDGGQTISADEMARLRDTINYEVTCDFGMRLEKVYV
>NZ_CP012069.2|WP_050342336.1|3185345_3186959_+|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase
MQPVLNVEDVKQVESDLTGVGVSISELMHRAGVSTAREVMGMGNVEEVVVMCGLGNNGGDGWVCSESLKARGIRVSVVTPVEPDAIRGDLARVVANSAEHAGVSVLVAPPRDQLEKVLAAADVVVDAMLGTGFHGIPRTPFDIWIDCVNDSDARVVAVDVPSGLSAQTGLSAGGCVSADLTVTMLVLKPGLLADQGRDTCGTIVVAPLAEQTEQLVREADPVAWRADLADYAGMLPPLSNADNKFTRGSVLVVGGSQRFVGAPVMAALAAARAGAGYVTLAVPAPIVPVIQSQLLEIPVLGLPAKDNGTFSDAAAIKIAELAEKRSCTLVGPGMRVTAGTVSVVSHLLSAEVPLVVDADGLNCIARLTSNSLDEFPELLRRSDPLVLTPHRGELGRLVGLQATPPNSLTTAMEAARRIVWADGGSELCVVAKGSATACLNAEVALLPKPGPASLATAGSGDALSGVIAALLARGSIDHEDLPTLTALACEIHGHAGSLAINERGSRGVMARDIIDMIGLAEDALEDDIAFPEGEPEE
>NZ_CP012069.2|WP_083444057.1|3184733_3185333_+|holo-ACP-synthase
MAVAGIGVDMLEIARMEAVMRRRPSFVARVFTEDERSYCDASPRPADHYAARFAAREAVLKALGTGFSEGVGFRDVSVRRADNGRPSCVLSGRAAEIAEARGVQEVAISLSTTHDEAVATAVMVTEAVRPKRDAAHGAATEFQASFKSARVIVDELEHLAGEGEDVRGHVDRDAGVRPIEVGTEEEQHARVGKSSREEA
>NZ_CP012069.2|WP_157051567.1|3198122_3198266_+|hypothetical-protein
MINDYLVANGPSTRTEIIEVTSPHLPASLTPEQRENKADNLLRKMRP
>NZ_CP012069.2|WP_050342350.1|3198878_3199520_-|Fic-family-protein
MIPQNKLGIASSIELAHEEERISKLAALSLYRDGALDKLEPGTFTTLQKIHVTLFGDIYDFAGRVRDVNLSKGSFRFASALYLQSALKSIEGMRQGDFEEIVEKYVEMNVAHPFREGNGRAGRIWLDHIFRCELGRTVDWSQIGHEDYLLAMERSPVRDLELKELLRGSLSNQLDNFTLLARGVDASYSYEGYATYRAEDLAQGSIRNERHED
>NZ_CP012069.2|WP_050342352.1|3199516_3199744_-|hypothetical-protein
MRYTGPLDSGVTPTEIKSYLRDSGLAPVTIRIPRTLRDSAKEAASLRGMNFTSFAKGLMIEELSRKTLARQVIER
>NZ_CP012069.2|WP_083444119.1|3199929_3200886_-|NADAR-family-protein
MVSILIEEALGRDVSGLWEEYFSVGPDEGASRPAASSEDGPTLIGFWREKDALGFCSNWHPSGLVFCGREFCTTEHWMMWQKARVMGDTGSADAILETPTPRRAKELGARVKPYDDALWRDVREQLVYVGVREKFMQNPKLAERLLTTGVAVLAEASPYDRSWGVGLAEHDKRFRDISRWRGSNLLGRVCMRVRSDLGLAAHAGVDVEKLSGCGNDMVFSLCDGRVGSMSLLELSRIPAARAAVLCYVRIAQHQASDTYPTLDDFLLRFGRETVAKIDERCRSGRDGDVGTGGGIGVVGWCELLSQLAFMSAVGLLWG
>NZ_CP012069.2|WP_050342354.1|3201466_3202528_-|Fic-family-protein
MLQFEYGKVLQRLMMPGVVSAIGDVREHRGRQELYKSLQPAVLDRLCEVAKIQGTGASNRIENISTSEVRLRELMERKVKPANRDEREIAGYRYVLDTIHESHDSIPITPGVILQLHRDLYRFQDVSFAGRWKDSDNTIAERTEDGSMVARFVPTSAAATPSAVERICDEYARWSKGATYDPLLVSLIFVFDFVSIHPFADGNGRMSRLLMLLLSYRSGYDVGKYVSIEAEIERTKTTYYEALAASSPRWAQGESDYAPFVTYLLGVMTACYRDLDERVSLLSSSAKGEDVLRAYFAGLTGTVTKRQIMDDNPTLSRRTVERVLQRLQAEGAVKKVGAARATAYQRIDQGEVS
>NZ_CP012069.2|WP_050342358.1|3203648_3204062_+|DUF4279-domain-containing-protein
MRPRANVRVLITGEGLDLDAITEALGVEPTYTRLGETYDDWEYTIPRAECASVSERLGTLRRALGDGAGRLAPALEGRDANVGVELSVHAVIGDEPDLTLTRGDLAFLGTLGAEFGIDPYPYYPDEADDLPPVGEGA
>NZ_CP012069.2|WP_050342362.1|3204063_3204576_+|DUF4279-domain-containing-protein
MRPRVETTLCVTGGRLDFEAISAALGLEPTSTCRAGELPAAVARAGLARDMWQHTIARERCMWPPSHIDRLQDAVGEGAARLRALLSGHVAKVAVVIDVEMEEFYHPFVGVTARNVAFLNSIGAELRMGWRIREPEDPEEYTDPERVARDVRRRRELGDALWAWGRAGGA
>NZ_CP012069.2|WP_157051568.1|3204734_3205973_+|hypothetical-protein
MATREAYEEWIDEVAIEVSCDDAWRDRLFSSPLGEELYVGCERPEEVPEYVRDGVVENSLSFLVATAPLEGDEYDVGMVSFAFWSREYPDVVTRTGNEPSPAQRVASDPASYWHEVGLVVRGAGPGGGTRDAREGSWCSWCVSEDDPSAGAEGSPGGGGAFGREGLPAVEDAFVSALEGAVRSSLSGPLVATDVPRLPDEGARLPLPSFPLPARGSAVSLERVGDAVRAMLRWGGGTLEGDHLVVTFGGDARFVVAPLPLRWGGGAHMFLASGSDLTAVAGRAESLGLRAVPRLSPFLPLDRLRGLGFPDGWELGVIRRCAEGVDPSLPGIVPDGAALWGLGAGQVDRLCAAVLPALSDLASGHPWGPCSSREDLLYDALLLLWWERTRSPGRLFELLTVATPGHGDPLGPS
>NZ_CP012069.2|WP_050342366.1|3207312_3208437_+|AAA-family-ATPase
MQYQNPFKPTAGKMPPALVGREKVTDDFLEGLANGEGAPGRLMRITGPRGSGKTVLLSELASIAEDEGWLVVNVSGSGDLLASLSRRLMRRSLFSEIAFKAQSPLASIEARRGPASLDDFESILECATRGMTKRGKGLLVTIDEVQDASRDDIREIATAVQFMIRENQNIALVFAGIATGVLDILNGKSVTFLRRAKPEELDAIPLDEVRDSLRDTIANSGFKIEEEALALATDATQGYAYLIQLVGYHVWRTAWLRGRRDDGVIVISVDDATRGVAAARDEFKSAVLEATITGLPKTAIDFILAMSETRDVVSTSKIASMLKRTTGYLSPYRRQLISRQVIEQTAPGYVTFSIPLMKEYLAEERASILSRYGE
>NZ_CP012069.2|WP_050342367.1|3208539_3209181_-|Type-1-glutamine-amidotransferase-like-domain-containing-protein
MRLFLTSYLAGTKGLAERFLSKARPREIVFVPTAANVEEYRGYVDEGMAALREMGYGLRVLDVAAVPSDEAARAIEGCDCLCVSGGNTFFLLQELRRSGLVELIAQRARQGMPYIGESAGAIIACPDIEYNQVMDDRAAAPGLDDCAGMGLVDWYVLPHNGEFPFAEATAETTRTYKDELDLVPLNNSQAAIVDDNGYSVVTEGAREAGDEEA

Crispr_ID: NZ_CP012069_39

• CRISPR_ID: NZ_CP012069_39
• CRISPR_location: 3210497-3210636
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP012069_39

Consensus_repeat	Method
AGTGTACACAAATGGCCCAAAACGGCGCCGAGAGGCCATTTTCGCC	CRISPRCasFinder

spacers of NZ_CP012069_39

>39.1|3210543|48|NZ_CP012069|CRISPRCasFinder
GATCTGTGTACACTCCTGCGTCTCCGCGCCTGCCCACAACGGCGCAAT

CRISPR arrays and Neighbor proteins around NZ_CP012069_39

CRISPR arrays

The CRISPR arrays of NZ_CP012069_39

>merge|NZ_CP012069|39|3210497-3210636|CRISPRCasFinder
AGTGTACACAAATGGCCCAAAACGGCGCCGAGAGGCCATTTTCGCCGATCTGTGTACACTCCTGCGTCTCCGCGCCTGCCCACAACGGCGCAATAGTGTACACAAATGGCCCAAAACGGCGCCGAGAGGTCATTTTCGCC

>NZ_CP012069|39|36|3210497-3210636|CRISPRCasFinder
AGTGTACACAAATGGCCCAAAACGGCGCCGAGAGGCCATTTTCGCC	GATCTGTGTACACTCCTGCGTCTCCGCGCCTGCCCACAACGGCGCAAT
AGTGTACACAAATGGCCCAAAACGGCGCCGAGAGGTCATTTTCGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012069.2|WP_050342350.1|3198878_3199520_-|Fic-family-protein	unknown	unknown	gnl|CDD|225095
NZ_CP012069.2|WP_050342366.1|3207312_3208437_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|379062
NZ_CP012069.2|WP_050342358.1|3203648_3204062_+|DUF4279-domain-containing-protein	unknown	unknown	gnl|CDD|372913
NZ_CP012069.2|WP_050344634.1|3211582_3212194_+|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl|CDD|227348
NZ_CP012069.2|WP_050342352.1|3199516_3199744_-|hypothetical-protein	unknown	unknown	gnl|CDD|181296
NZ_CP012069.2|WP_157051568.1|3204734_3205973_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342371.1|3210941_3211223_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP012069.2|WP_050342362.1|3204063_3204576_+|DUF4279-domain-containing-protein	unknown	unknown	gnl|CDD|372913
NZ_CP012069.2|WP_050342354.1|3201466_3202528_-|Fic-family-protein	unknown	unknown	gnl|CDD|225718
NZ_CP012069.2|WP_050342367.1|3208539_3209181_-|Type-1-glutamine-amidotransferase-like-domain-containing-protein	unknown	unknown	gnl|CDD|225877
NZ_CP012069.2|WP_083444119.1|3199929_3200886_-|NADAR-family-protein	unknown	unknown	gnl|CDD|271319
NZ_CP012069.2|WP_050342369.1|3209306_3209978_-|DUF3800-domain-containing-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP012069.2|WP_050342350.1|3198878_3199520_-|Fic-family-protein	gnl|CDD|225095	COG2184, Fic, Protein involved in cell division [Cell division and chromosome partitioning].	9.79449e-37
NZ_CP012069.2|WP_050342354.1|3201466_3202528_-|Fic-family-protein	gnl|CDD|225718	COG3177, COG3177, Fic family protein [Function unknown].	5.05947e-20
NZ_CP012069.2|WP_050342358.1|3203648_3204062_+|DUF4279-domain-containing-protein	gnl|CDD|372913	pfam14106, DUF4279, Domain of unknown function (DUF4279). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	3.68076e-09
NZ_CP012069.2|WP_050344634.1|3211582_3212194_+|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl|CDD|227348	COG5015, COG5015, Uncharacterized conserved protein [Function unknown].	3.13116e-23
NZ_CP012069.2|WP_050342352.1|3199516_3199744_-|hypothetical-protein	gnl|CDD|181296	PRK08215, PRK08215, RNA polymerase sporulation sigma factor SigG.	0.00310385
NZ_CP012069.2|WP_050342367.1|3208539_3209181_-|Type-1-glutamine-amidotransferase-like-domain-containing-protein	gnl|CDD|225877	COG3340, PepE, Peptidase E [Amino acid transport and metabolism].	8.47277e-55
NZ_CP012069.2|WP_050342366.1|3207312_3208437_+|AAA-family-ATPase	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	2.31785e-08
NZ_CP012069.2|WP_083444119.1|3199929_3200886_-|NADAR-family-protein	gnl|CDD|271319	cd15457, NADAR, Escherichia coli swarming motility protein YbiA and related proteins. This family of uncharacterized domains was initially classified as Domain of Unknown Function (DUF1768). It contains members such as the E. coli swarming motility protein YbiA. Mutations in YbiA cause defects in Escherichia coli swarming, but not necessarily in motility. More recently, this family has been predicted to be involved in NAD-utilizing pathways, likely to act on ADP-ribose derivatives, and has been named the NADAR (NAD and ADP-ribose) superfamily.	7.04823e-59
NZ_CP012069.2|WP_050342362.1|3204063_3204576_+|DUF4279-domain-containing-protein	gnl|CDD|372913	pfam14106, DUF4279, Domain of unknown function (DUF4279). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	4.07787e-07

Protein sequences

>NZ_CP012069.2|WP_050342369.1|3209306_3209978_-|DUF3800-domain-containing-protein
MRELSIFIDESGSDGLDGSYYLLALVLHEQGDSLERAIAQYEQSLRDKGLPNAPLHTTPLLYHKKGYEGMDEETRKRLLSSFRVFFRHLPIRHACLALDTKEFTSPDDVMVGMRRSLVDFMFDHLEYLQGFDDIKVYYDDGQNSIARAIHGAVEYVLSKNAVILKKAPPADYRLGQAADYICTVELAALRYRDKRTTATGEKFFGSWSRFRRGVLKEVRAKRM
>NZ_CP012069.2|WP_050342367.1|3208539_3209181_-|Type-1-glutamine-amidotransferase-like-domain-containing-protein
MRLFLTSYLAGTKGLAERFLSKARPREIVFVPTAANVEEYRGYVDEGMAALREMGYGLRVLDVAAVPSDEAARAIEGCDCLCVSGGNTFFLLQELRRSGLVELIAQRARQGMPYIGESAGAIIACPDIEYNQVMDDRAAAPGLDDCAGMGLVDWYVLPHNGEFPFAEATAETTRTYKDELDLVPLNNSQAAIVDDNGYSVVTEGAREAGDEEA
>NZ_CP012069.2|WP_050342366.1|3207312_3208437_+|AAA-family-ATPase
MQYQNPFKPTAGKMPPALVGREKVTDDFLEGLANGEGAPGRLMRITGPRGSGKTVLLSELASIAEDEGWLVVNVSGSGDLLASLSRRLMRRSLFSEIAFKAQSPLASIEARRGPASLDDFESILECATRGMTKRGKGLLVTIDEVQDASRDDIREIATAVQFMIRENQNIALVFAGIATGVLDILNGKSVTFLRRAKPEELDAIPLDEVRDSLRDTIANSGFKIEEEALALATDATQGYAYLIQLVGYHVWRTAWLRGRRDDGVIVISVDDATRGVAAARDEFKSAVLEATITGLPKTAIDFILAMSETRDVVSTSKIASMLKRTTGYLSPYRRQLISRQVIEQTAPGYVTFSIPLMKEYLAEERASILSRYGE
>NZ_CP012069.2|WP_157051568.1|3204734_3205973_+|hypothetical-protein
MATREAYEEWIDEVAIEVSCDDAWRDRLFSSPLGEELYVGCERPEEVPEYVRDGVVENSLSFLVATAPLEGDEYDVGMVSFAFWSREYPDVVTRTGNEPSPAQRVASDPASYWHEVGLVVRGAGPGGGTRDAREGSWCSWCVSEDDPSAGAEGSPGGGGAFGREGLPAVEDAFVSALEGAVRSSLSGPLVATDVPRLPDEGARLPLPSFPLPARGSAVSLERVGDAVRAMLRWGGGTLEGDHLVVTFGGDARFVVAPLPLRWGGGAHMFLASGSDLTAVAGRAESLGLRAVPRLSPFLPLDRLRGLGFPDGWELGVIRRCAEGVDPSLPGIVPDGAALWGLGAGQVDRLCAAVLPALSDLASGHPWGPCSSREDLLYDALLLLWWERTRSPGRLFELLTVATPGHGDPLGPS
>NZ_CP012069.2|WP_050342362.1|3204063_3204576_+|DUF4279-domain-containing-protein
MRPRVETTLCVTGGRLDFEAISAALGLEPTSTCRAGELPAAVARAGLARDMWQHTIARERCMWPPSHIDRLQDAVGEGAARLRALLSGHVAKVAVVIDVEMEEFYHPFVGVTARNVAFLNSIGAELRMGWRIREPEDPEEYTDPERVARDVRRRRELGDALWAWGRAGGA
>NZ_CP012069.2|WP_050342358.1|3203648_3204062_+|DUF4279-domain-containing-protein
MRPRANVRVLITGEGLDLDAITEALGVEPTYTRLGETYDDWEYTIPRAECASVSERLGTLRRALGDGAGRLAPALEGRDANVGVELSVHAVIGDEPDLTLTRGDLAFLGTLGAEFGIDPYPYYPDEADDLPPVGEGA
>NZ_CP012069.2|WP_050342354.1|3201466_3202528_-|Fic-family-protein
MLQFEYGKVLQRLMMPGVVSAIGDVREHRGRQELYKSLQPAVLDRLCEVAKIQGTGASNRIENISTSEVRLRELMERKVKPANRDEREIAGYRYVLDTIHESHDSIPITPGVILQLHRDLYRFQDVSFAGRWKDSDNTIAERTEDGSMVARFVPTSAAATPSAVERICDEYARWSKGATYDPLLVSLIFVFDFVSIHPFADGNGRMSRLLMLLLSYRSGYDVGKYVSIEAEIERTKTTYYEALAASSPRWAQGESDYAPFVTYLLGVMTACYRDLDERVSLLSSSAKGEDVLRAYFAGLTGTVTKRQIMDDNPTLSRRTVERVLQRLQAEGAVKKVGAARATAYQRIDQGEVS
>NZ_CP012069.2|WP_083444119.1|3199929_3200886_-|NADAR-family-protein
MVSILIEEALGRDVSGLWEEYFSVGPDEGASRPAASSEDGPTLIGFWREKDALGFCSNWHPSGLVFCGREFCTTEHWMMWQKARVMGDTGSADAILETPTPRRAKELGARVKPYDDALWRDVREQLVYVGVREKFMQNPKLAERLLTTGVAVLAEASPYDRSWGVGLAEHDKRFRDISRWRGSNLLGRVCMRVRSDLGLAAHAGVDVEKLSGCGNDMVFSLCDGRVGSMSLLELSRIPAARAAVLCYVRIAQHQASDTYPTLDDFLLRFGRETVAKIDERCRSGRDGDVGTGGGIGVVGWCELLSQLAFMSAVGLLWG
>NZ_CP012069.2|WP_050342352.1|3199516_3199744_-|hypothetical-protein
MRYTGPLDSGVTPTEIKSYLRDSGLAPVTIRIPRTLRDSAKEAASLRGMNFTSFAKGLMIEELSRKTLARQVIER
>NZ_CP012069.2|WP_050342350.1|3198878_3199520_-|Fic-family-protein
MIPQNKLGIASSIELAHEEERISKLAALSLYRDGALDKLEPGTFTTLQKIHVTLFGDIYDFAGRVRDVNLSKGSFRFASALYLQSALKSIEGMRQGDFEEIVEKYVEMNVAHPFREGNGRAGRIWLDHIFRCELGRTVDWSQIGHEDYLLAMERSPVRDLELKELLRGSLSNQLDNFTLLARGVDASYSYEGYATYRAEDLAQGSIRNERHED
>NZ_CP012069.2|WP_050342371.1|3210941_3211223_-|hypothetical-protein
MSAATERGRAPTTTSRAAAHTRRASGWPAKGVHEAYRADVRNPIRLERVAMVSDLHPLSQAPPVAIHRMNMKYIRSYLNWRVHLFRVKQANER
>NZ_CP012069.2|WP_050344634.1|3211582_3212194_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MTAQDCLELLREIRDVTFSTVDAQGHPQARVIDVMGVGEGCVTFCTARGKDFYAQLRHNPHVAVVGLSKDWQSVRLVGVARRLPDEGQRAAIDLIFADNPSMESVYPGEARYILEAFMIDRGTLEVFDLASEPIFRRSFSLGGAPLGLRGFLIADDCVGCGTCKEGCPQQCIDEGEPYWINQESCLHCGLCYENCPVGAIDRR

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	208956-208990	0	1.0
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	2944617-2944651	0	1.0
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	2132529-2132563	0	1.0
NZ_CP012069_20	20.1|1937505|38|NZ_CP012069|CRISPRCasFinder	1937505-1937542	38	NZ_CP012069.2	1890674-1890711	0	1.0
NZ_CP012069_25	25.1|2318208|36|NZ_CP012069|CRISPRCasFinder	2318208-2318243	36	NZ_CP012069.2	2318354-2318389	0	1.0
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	1207092-1207129	1	0.974
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	1267788-1267825	1	0.974
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	2413502-2413539	1	0.974
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	1213136-1213173	1	0.974
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	1681004-1681041	1	0.974
NZ_CP012069_7	7.1|386264|61|NZ_CP012069|PILER-CR	386264-386324	61	NZ_CP012069.2	387128-387188	1	0.984
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	58118-58154	1	0.973
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	208528-208564	1	0.973
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	1148537-1148573	1	0.973
NZ_CP012069_13	13.1|687170|36|NZ_CP012069|CRISPRCasFinder	687170-687205	36	NZ_CP012069.2	1890675-1890710	1	0.972
NZ_CP012069_13	13.1|687170|36|NZ_CP012069|CRISPRCasFinder	687170-687205	36	NZ_CP012069.2	2944407-2944442	1	0.972
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	179380-179414	1	0.971
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	208528-208562	1	0.971
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1031298-1031332	1	0.971
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1148111-1148145	1	0.971
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1148537-1148571	1	0.971
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1895274-1895308	1	0.971
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	1207092-1207128	1	0.973
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	1267788-1267824	1	0.973
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	2413502-2413538	1	0.973
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	208528-208564	1	0.973
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	1148537-1148573	1	0.973
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	1213137-1213173	1	0.973
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	1681005-1681041	1	0.973
NZ_CP012069_25	25.1|2318208|36|NZ_CP012069|CRISPRCasFinder	2318208-2318243	36	NZ_CP012069.2	2986526-2986561	1	0.972
NZ_CP012069_26	26.1|2441318|38|NZ_CP012069|CRISPRCasFinder	2441318-2441355	38	NZ_CP012069.2	584211-584248	1	0.974
NZ_CP012069_28	28.1|2529183|38|NZ_CP012069|CRISPRCasFinder	2529183-2529220	38	NZ_CP012069.2	3038617-3038654	1	0.974
NZ_CP012069_28	28.1|2529183|38|NZ_CP012069|CRISPRCasFinder	2529183-2529220	38	NZ_CP012069.2	3042106-3042143	1	0.974
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	1207092-1207129	1	0.974
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	1267788-1267825	1	0.974
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	2413502-2413539	1	0.974
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	1213136-1213173	1	0.974
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	1681004-1681041	1	0.974
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	1175878-1175915	2	0.947
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	58117-58154	2	0.947
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	208527-208564	2	0.947
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	1148110-1148147	2	0.947
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	1148536-1148573	2	0.947
NZ_CP012069_3	3.1|223964|38|NZ_CP012069|CRISPRCasFinder	223964-224001	38	NZ_CP012069.2	1213566-1213603	2	0.947
NZ_CP012069_7	7.1|386264|61|NZ_CP012069|PILER-CR	386264-386324	61	NZ_CP012069.2	386156-386216	2	0.967
NZ_CP012069_7	7.3|386480|61|NZ_CP012069|PILER-CR	386480-386540	61	NZ_CP012069.2	386804-386864	2	0.967
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	1207092-1207128	2	0.946
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	1267788-1267824	2	0.946
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	2132527-2132563	2	0.946
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	2413502-2413538	2	0.946
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	208956-208992	2	0.946
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	859887-859923	2	0.946
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	1213137-1213173	2	0.946
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	1213995-1214031	2	0.946
NZ_CP012069_12	12.1|665655|37|NZ_CP012069|CRISPRCasFinder	665655-665691	37	NZ_CP012069.2	1681005-1681041	2	0.946
NZ_CP012069_13	13.1|687170|36|NZ_CP012069|CRISPRCasFinder	687170-687205	36	NZ_CP012069.2	1480404-1480439	2	0.944
NZ_CP012069_13	13.1|687170|36|NZ_CP012069|CRISPRCasFinder	687170-687205	36	NZ_CP012069.2	3035241-3035276	2	0.944
NZ_CP012069_14	14.1|972710|38|NZ_CP012069|CRISPRCasFinder	972710-972747	38	NZ_CP012069.2	1895272-1895309	2	0.947
NZ_CP012069_18	18.1|1715626|53|NZ_CP012069|CRISPRCasFinder	1715626-1715678	53	NZ_CP012069.2	2914309-2914361	2	0.962
NZ_CP012069_18	18.1|1715626|53|NZ_CP012069|CRISPRCasFinder	1715626-1715678	53	NZ_CP012069.2	2438137-2438189	2	0.962
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	584211-584245	2	0.943
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	859887-859921	2	0.943
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1213137-1213171	2	0.943
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1213995-1214029	2	0.943
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1681005-1681039	2	0.943
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1890675-1890709	2	0.943
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	2944407-2944441	2	0.943
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1207094-1207128	2	0.943
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1267790-1267824	2	0.943
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	1663661-1663695	2	0.943
NZ_CP012069_19	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	NZ_CP012069.2	2413504-2413538	2	0.943
NZ_CP012069_20	20.1|1937505|38|NZ_CP012069|CRISPRCasFinder	1937505-1937542	38	NZ_CP012069.2	208955-208992	2	0.947
NZ_CP012069_20	20.1|1937505|38|NZ_CP012069|CRISPRCasFinder	1937505-1937542	38	NZ_CP012069.2	859886-859923	2	0.947
NZ_CP012069_20	20.1|1937505|38|NZ_CP012069|CRISPRCasFinder	1937505-1937542	38	NZ_CP012069.2	1213994-1214031	2	0.947
NZ_CP012069_20	20.1|1937505|38|NZ_CP012069|CRISPRCasFinder	1937505-1937542	38	NZ_CP012069.2	2132527-2132564	2	0.947
NZ_CP012069_20	20.1|1937505|38|NZ_CP012069|CRISPRCasFinder	1937505-1937542	38	NZ_CP012069.2	3038617-3038654	2	0.947
NZ_CP012069_20	20.1|1937505|38|NZ_CP012069|CRISPRCasFinder	1937505-1937542	38	NZ_CP012069.2	3042106-3042143	2	0.947
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	1175878-1175914	2	0.946
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	2132527-2132563	2	0.946
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	58118-58154	2	0.946
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	208956-208992	2	0.946
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	859887-859923	2	0.946
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	1148111-1148147	2	0.946
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	1213567-1213603	2	0.946
NZ_CP012069_24	24.1|2296729|37|NZ_CP012069|CRISPRCasFinder	2296729-2296765	37	NZ_CP012069.2	1213995-1214031	2	0.946
NZ_CP012069_25	25.1|2318208|36|NZ_CP012069|CRISPRCasFinder	2318208-2318243	36	NZ_CP012069.2	1344005-1344040	2	0.944
NZ_CP012069_25	25.1|2318208|36|NZ_CP012069|CRISPRCasFinder	2318208-2318243	36	NZ_CP012069.2	1344110-1344145	2	0.944
NZ_CP012069_25	25.1|2318208|36|NZ_CP012069|CRISPRCasFinder	2318208-2318243	36	NZ_CP012069.2	1344256-1344291	2	0.944
NZ_CP012069_25	25.1|2318208|36|NZ_CP012069|CRISPRCasFinder	2318208-2318243	36	NZ_CP012069.2	1344402-1344437	2	0.944
NZ_CP012069_26	26.1|2441318|38|NZ_CP012069|CRISPRCasFinder	2441318-2441355	38	NZ_CP012069.2	1031298-1031335	2	0.947
NZ_CP012069_26	26.1|2441318|38|NZ_CP012069|CRISPRCasFinder	2441318-2441355	38	NZ_CP012069.2	1854234-1854271	2	0.947
NZ_CP012069_28	28.1|2529183|38|NZ_CP012069|CRISPRCasFinder	2529183-2529220	38	NZ_CP012069.2	452207-452244	2	0.947
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	1175878-1175915	2	0.947
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	58117-58154	2	0.947
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	208527-208564	2	0.947
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	1148110-1148147	2	0.947
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	1148536-1148573	2	0.947
NZ_CP012069_30	30.1|2716475|38|NZ_CP012069|CRISPRCasFinder	2716475-2716512	38	NZ_CP012069.2	1213566-1213603	2	0.947
NZ_CP012069_7	7.4|386588|78|NZ_CP012069|PILER-CR	386588-386665	78	NZ_CP012069.2	386895-386972	18	0.769

1. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 208956-208990, mismatch: 0, identity: 1.0

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgagccattttccatagt	Protospacer
***********************************

2. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 2944617-2944651, mismatch: 0, identity: 1.0

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgagccattttccatagt	Protospacer
***********************************

3. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 2132529-2132563, mismatch: 0, identity: 1.0

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgagccattttccatagt	Protospacer
***********************************

4. spacer 20.1|1937505|38|NZ_CP012069|CRISPRCasFinder matches to position: 1890674-1890711, mismatch: 0, identity: 1.0

tcgagcgcgtttgcccagttgggccattttccatagtg	CRISPR spacer
tcgagcgcgtttgcccagttgggccattttccatagtg	Protospacer
**************************************

5. spacer 25.1|2318208|36|NZ_CP012069|CRISPRCasFinder matches to position: 2318354-2318389, mismatch: 0, identity: 1.0

cacactgccactcgacgtcgagcgtaccaaggcggt	CRISPR spacer
cacactgccactcgacgtcgagcgtaccaaggcggt	Protospacer
************************************

6. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 1207092-1207129, mismatch: 1, identity: 0.974

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatggagaatgcctcaactgggcaaatgcgctcga	Protospacer
*****************************.********

7. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 1267788-1267825, mismatch: 1, identity: 0.974

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatggagaatgcctcaactgggcaaatgcgctcga	Protospacer
*****************************.********

8. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 2413502-2413539, mismatch: 1, identity: 0.974

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatggagaatgcctcaactgggcaaatgcgctcga	Protospacer
*****************************.********

9. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 1213136-1213173, mismatch: 1, identity: 0.974

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatggagaatgcctcaactgggcaaatgcgctcga	Protospacer
*****************************.********

10. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 1681004-1681041, mismatch: 1, identity: 0.974

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatggagaatgcctcaactgggcaaatgcgctcga	Protospacer
*****************************.********

11. spacer 7.1|386264|61|NZ_CP012069|PILER-CR matches to position: 387128-387188, mismatch: 1, identity: 0.984

ctcgtacatcatgcccagcctgtactgcgcccaaggctcgccctgctcggccgcgagccg	CRISPR spacer
ctcgtacatcatgcccagcctgtactgcgcccaaggctcgccctgctcggccgcgagccg	Protospacer
************************************************************

12. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 58118-58154, mismatch: 1, identity: 0.973

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatctgcccagttgaggcattctccatagt	Protospacer
*********************** *************

13. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 208528-208564, mismatch: 1, identity: 0.973

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgagccattctccatagt	Protospacer
**********.**************************

14. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 1148537-1148573, mismatch: 1, identity: 0.973

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgagccattctccatagt	Protospacer
**********.**************************

15. spacer 13.1|687170|36|NZ_CP012069|CRISPRCasFinder matches to position: 1890675-1890710, mismatch: 1, identity: 0.972

actatggaaaatggcccaactgggcaaacgcgcccg	CRISPR spacer
actatggaaaatggcccaactgggcaaacgcgctcg	Protospacer
*********************************.**

16. spacer 13.1|687170|36|NZ_CP012069|CRISPRCasFinder matches to position: 2944407-2944442, mismatch: 1, identity: 0.972

actatggaaaatggcccaactgggcaaacgcgcccg	CRISPR spacer
actatggaaaatggcccaactgggcaaacgcgctcg	Protospacer
*********************************.**

17. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 179380-179414, mismatch: 1, identity: 0.971

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgagctattttccatagt	Protospacer
**********************.************

18. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 208528-208562, mismatch: 1, identity: 0.971

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgagccattctccatagt	Protospacer
**************************.********

19. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1031298-1031332, mismatch: 1, identity: 0.971

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgagccactttccatagt	Protospacer
************************.**********

20. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1148111-1148145, mismatch: 1, identity: 0.971

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgaggcattttccatagt	Protospacer
********************* *************

21. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1148537-1148571, mismatch: 1, identity: 0.971

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgagccattctccatagt	Protospacer
**************************.********

22. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1895274-1895308, mismatch: 1, identity: 0.971

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gaacgcatttgcccagttgagccattttccatagt	Protospacer
**.********************************

23. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 1207092-1207128, mismatch: 1, identity: 0.973

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatgcctcaactgggcaaatgcgctcga	Protospacer
*************.***********************

24. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 1267788-1267824, mismatch: 1, identity: 0.973

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatgcctcaactgggcaaatgcgctcga	Protospacer
*************.***********************

25. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 2413502-2413538, mismatch: 1, identity: 0.973

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatgcctcaactgggcaaatgcgctcga	Protospacer
*************.***********************

26. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 208528-208564, mismatch: 1, identity: 0.973

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatggctcaactgggcaaatgcgctcga	Protospacer
************* ***********************

27. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 1148537-1148573, mismatch: 1, identity: 0.973

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatggctcaactgggcaaatgcgctcga	Protospacer
************* ***********************

28. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 1213137-1213173, mismatch: 1, identity: 0.973

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatgcctcaactgggcaaatgcgctcga	Protospacer
*************.***********************

29. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 1681005-1681041, mismatch: 1, identity: 0.973

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatgcctcaactgggcaaatgcgctcga	Protospacer
*************.***********************

30. spacer 25.1|2318208|36|NZ_CP012069|CRISPRCasFinder matches to position: 2986526-2986561, mismatch: 1, identity: 0.972

cacactgccactcgacgtcgagcgtaccaaggcggt	CRISPR spacer
cacactgccactcgacgtcgagcgtaccaagacggt	Protospacer
*******************************.****

31. spacer 26.1|2441318|38|NZ_CP012069|CRISPRCasFinder matches to position: 584211-584248, mismatch: 1, identity: 0.974

ctcgagcgcatttgcccagttgagcctcttttcatagt	CRISPR spacer
ctcgagcgcatttgcccagttgagcctctttccatagt	Protospacer
*******************************.******

32. spacer 28.1|2529183|38|NZ_CP012069|CRISPRCasFinder matches to position: 3038617-3038654, mismatch: 1, identity: 0.974

tcgagcacgtttgcccagttgggccactctccatagtg	CRISPR spacer
tcgagcacgtttgcccagttgggccactttccatagtg	Protospacer
****************************.*********

33. spacer 28.1|2529183|38|NZ_CP012069|CRISPRCasFinder matches to position: 3042106-3042143, mismatch: 1, identity: 0.974

tcgagcacgtttgcccagttgggccactctccatagtg	CRISPR spacer
tcgagcacgtttgcccagttgggccattctccatagtg	Protospacer
**************************.***********

34. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 1207092-1207129, mismatch: 1, identity: 0.974

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagcgcatttgcccagttgaggcattctccatagtg	Protospacer
*******************************.******

35. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 1267788-1267825, mismatch: 1, identity: 0.974

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagcgcatttgcccagttgaggcattctccatagtg	Protospacer
*******************************.******

36. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 2413502-2413539, mismatch: 1, identity: 0.974

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagcgcatttgcccagttgaggcattctccatagtg	Protospacer
*******************************.******

37. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 1213136-1213173, mismatch: 1, identity: 0.974

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagcgcatttgcccagttgaggcattctccatagtg	Protospacer
*******************************.******

38. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 1681004-1681041, mismatch: 1, identity: 0.974

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagcgcatttgcccagttgaggcattctccatagtg	Protospacer
*******************************.******

39. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 1175878-1175915, mismatch: 2, identity: 0.947

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatgaagaatgcctcaactgggcaaatgcgctcga	Protospacer
*******.*********************.********

40. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 58117-58154, mismatch: 2, identity: 0.947

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatggagaatgcctcaactgggcagatgcgctcga	Protospacer
***************************.*.********

41. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 208527-208564, mismatch: 2, identity: 0.947

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatggagaatggctcaactgggcaaatgcgctcga	Protospacer
************** **************.********

42. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 1148110-1148147, mismatch: 2, identity: 0.947

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatggaaaatgcctcaactgggcaaatgcgctcga	Protospacer
*********.*******************.********

43. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 1148536-1148573, mismatch: 2, identity: 0.947

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatggagaatggctcaactgggcaaatgcgctcga	Protospacer
************** **************.********

44. spacer 3.1|223964|38|NZ_CP012069|CRISPRCasFinder matches to position: 1213566-1213603, mismatch: 2, identity: 0.947

cactatggagaatgcctcaactgggcaaacgcgctcga	CRISPR spacer
cactatggagaatgcctcaactgggcaaatgcactcga	Protospacer
*****************************.**.*****

45. spacer 7.1|386264|61|NZ_CP012069|PILER-CR matches to position: 386156-386216, mismatch: 2, identity: 0.967

ctcgtacatcatgcccagcctgtactgcgcccaaggctcgccctgctcggccgcgagccg	CRISPR spacer
ctcgtacatcatgcccagcctgtactgcgcccaaggctcgccctgctcggtcgcgagccg	Protospacer
**************************************************.*********

46. spacer 7.3|386480|61|NZ_CP012069|PILER-CR matches to position: 386804-386864, mismatch: 2, identity: 0.967

ctcatacatgaagccgagccagctttgcgcatccgcctcgccctgctcggccgcgagccg	CRISPR spacer
ctcgtacatgaagccgagccagctttgcgcatccgcctcgccctgctcggccgcgagccg	Protospacer
***.********************************************************

47. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 1207092-1207128, mismatch: 2, identity: 0.946

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgaggcattctccatagt	Protospacer
**********.************ *************

48. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 1267788-1267824, mismatch: 2, identity: 0.946

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgaggcattctccatagt	Protospacer
**********.************ *************

49. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 2132527-2132563, mismatch: 2, identity: 0.946

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgagccattttccatagt	Protospacer
**********.*****************.********

50. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 2413502-2413538, mismatch: 2, identity: 0.946

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgaggcattctccatagt	Protospacer
**********.************ *************

51. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 208956-208992, mismatch: 2, identity: 0.946

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgagccattttccatagt	Protospacer
**********.*****************.********

52. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 859887-859923, mismatch: 2, identity: 0.946

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgggccattctccatagt	Protospacer
**********.**********.***************

53. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 1213137-1213173, mismatch: 2, identity: 0.946

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgaggcattctccatagt	Protospacer
**********.************ *************

54. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 1213995-1214031, mismatch: 2, identity: 0.946

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgggccattctccatagt	Protospacer
**********.**********.***************

55. spacer 12.1|665655|37|NZ_CP012069|CRISPRCasFinder matches to position: 1681005-1681041, mismatch: 2, identity: 0.946

tcgagcgcatctgcccagttgagccattctccatagt	CRISPR spacer
tcgagcgcatttgcccagttgaggcattctccatagt	Protospacer
**********.************ *************

56. spacer 13.1|687170|36|NZ_CP012069|CRISPRCasFinder matches to position: 1480404-1480439, mismatch: 2, identity: 0.944

actatggaaaatggcccaactgggcaaacgcgcccg	CRISPR spacer
actatggaaagtggcccaactgggcaaacgcgctcg	Protospacer
**********.**********************.**

57. spacer 13.1|687170|36|NZ_CP012069|CRISPRCasFinder matches to position: 3035241-3035276, mismatch: 2, identity: 0.944

actatggaaaatggcccaactgggcaaacgcgcccg	CRISPR spacer
actatggagaatggcccaactgggcaaacgcgctcg	Protospacer
********.************************.**

58. spacer 14.1|972710|38|NZ_CP012069|CRISPRCasFinder matches to position: 1895272-1895309, mismatch: 2, identity: 0.947

cactatggaaaatggcccaactgggcaaatgcgtccga	CRISPR spacer
cactatggaaaatggctcaactgggcaaatgcgttcga	Protospacer
****************.*****************.***

59. spacer 18.1|1715626|53|NZ_CP012069|CRISPRCasFinder matches to position: 2914309-2914361, mismatch: 2, identity: 0.962

tggggcatttgtgtacactgttgggccgttgcgctgttgtggacagacgtggg	CRISPR spacer
tggggcgtttgtgtacactgttgggctgttgcgctgttgtggacagacgtggg	Protospacer
******.*******************.**************************

60. spacer 18.1|1715626|53|NZ_CP012069|CRISPRCasFinder matches to position: 2438137-2438189, mismatch: 2, identity: 0.962

tggggcatttgtgtacactgttgggccgttgcgctgttgtggacagacgtggg	CRISPR spacer
tggggcgtttgtgtacactgttgggctgttgcgctgttgtggacagacgtggg	Protospacer
******.*******************.**************************

61. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 584211-584245, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgagcctctttccatagt	Protospacer
*********************** .**********

62. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 859887-859921, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgggccattctccatagt	Protospacer
*******************.******.********

63. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1213137-1213171, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgaggcattctccatagt	Protospacer
********************* ****.********

64. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1213995-1214029, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgggccattctccatagt	Protospacer
*******************.******.********

65. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1681005-1681039, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgaggcattctccatagt	Protospacer
********************* ****.********

66. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1890675-1890709, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcgtttgcccagttgggccattttccatagt	Protospacer
******.************.***************

67. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 2944407-2944441, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcgtttgcccagttgggccattttccatagt	Protospacer
******.************.***************

68. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1207094-1207128, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgaggcattctccatagt	Protospacer
********************* ****.********

69. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1267790-1267824, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgaggcattctccatagt	Protospacer
********************* ****.********

70. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 1663661-1663695, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gaacgcatttgcccagttgagccatttttcatagt	Protospacer
**.*************************.******

71. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to position: 2413504-2413538, mismatch: 2, identity: 0.943

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcatttgcccagttgaggcattctccatagt	Protospacer
********************* ****.********

72. spacer 20.1|1937505|38|NZ_CP012069|CRISPRCasFinder matches to position: 208955-208992, mismatch: 2, identity: 0.947

tcgagcgcgtttgcccagttgggccattttccatagtg	CRISPR spacer
tcgagcgcatttgcccagttgagccattttccatagtg	Protospacer
********.************.****************

73. spacer 20.1|1937505|38|NZ_CP012069|CRISPRCasFinder matches to position: 859886-859923, mismatch: 2, identity: 0.947

tcgagcgcgtttgcccagttgggccattttccatagtg	CRISPR spacer
tcgagcgcatttgcccagttgggccattctccatagtg	Protospacer
********.*******************.*********

74. spacer 20.1|1937505|38|NZ_CP012069|CRISPRCasFinder matches to position: 1213994-1214031, mismatch: 2, identity: 0.947

tcgagcgcgtttgcccagttgggccattttccatagtg	CRISPR spacer
tcgagcgcatttgcccagttgggccattctccatagtg	Protospacer
********.*******************.*********

75. spacer 20.1|1937505|38|NZ_CP012069|CRISPRCasFinder matches to position: 2132527-2132564, mismatch: 2, identity: 0.947

tcgagcgcgtttgcccagttgggccattttccatagtg	CRISPR spacer
tcgagcgcatttgcccagttgagccattttccatagtg	Protospacer
********.************.****************

76. spacer 20.1|1937505|38|NZ_CP012069|CRISPRCasFinder matches to position: 3038617-3038654, mismatch: 2, identity: 0.947

tcgagcgcgtttgcccagttgggccattttccatagtg	CRISPR spacer
tcgagcacgtttgcccagttgggccactttccatagtg	Protospacer
******.*******************.***********

77. spacer 20.1|1937505|38|NZ_CP012069|CRISPRCasFinder matches to position: 3042106-3042143, mismatch: 2, identity: 0.947

tcgagcgcgtttgcccagttgggccattttccatagtg	CRISPR spacer
tcgagcacgtttgcccagttgggccattctccatagtg	Protospacer
******.*********************.*********

78. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 1175878-1175914, mismatch: 2, identity: 0.946

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatgaagaatgcctcaactgggcaaatgcgctcga	Protospacer
******.******.***********************

79. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 2132527-2132563, mismatch: 2, identity: 0.946

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggaaaatggctcaactgggcaaatgcgctcga	Protospacer
********.**** ***********************

80. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 58118-58154, mismatch: 2, identity: 0.946

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatgcctcaactgggcagatgcgctcga	Protospacer
*************.************.**********

81. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 208956-208992, mismatch: 2, identity: 0.946

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggaaaatggctcaactgggcaaatgcgctcga	Protospacer
********.**** ***********************

82. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 859887-859923, mismatch: 2, identity: 0.946

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatggcccaactgggcaaatgcgctcga	Protospacer
************* *.*********************

83. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 1148111-1148147, mismatch: 2, identity: 0.946

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggaaaatgcctcaactgggcaaatgcgctcga	Protospacer
********.****.***********************

84. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 1213567-1213603, mismatch: 2, identity: 0.946

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatgcctcaactgggcaaatgcactcga	Protospacer
*************.*****************.*****

85. spacer 24.1|2296729|37|NZ_CP012069|CRISPRCasFinder matches to position: 1213995-1214031, mismatch: 2, identity: 0.946

actatggagaatgtctcaactgggcaaatgcgctcga	CRISPR spacer
actatggagaatggcccaactgggcaaatgcgctcga	Protospacer
************* *.*********************

86. spacer 25.1|2318208|36|NZ_CP012069|CRISPRCasFinder matches to position: 1344005-1344040, mismatch: 2, identity: 0.944

cacactgccactcgacgtcgagcgtaccaaggcggt	CRISPR spacer
cacactgccactcgacgtcgagcgtaccaaaacggt	Protospacer
******************************..****

87. spacer 25.1|2318208|36|NZ_CP012069|CRISPRCasFinder matches to position: 1344110-1344145, mismatch: 2, identity: 0.944

cacactgccactcgacgtcgagcgtaccaaggcggt	CRISPR spacer
cacactgccactcgacgtcgagcgcaccaagacggt	Protospacer
************************.******.****

88. spacer 25.1|2318208|36|NZ_CP012069|CRISPRCasFinder matches to position: 1344256-1344291, mismatch: 2, identity: 0.944

cacactgccactcgacgtcgagcgtaccaaggcggt	CRISPR spacer
cacactgccactcgacgtcgagcgtaccgagacggt	Protospacer
****************************.**.****

89. spacer 25.1|2318208|36|NZ_CP012069|CRISPRCasFinder matches to position: 1344402-1344437, mismatch: 2, identity: 0.944

cacactgccactcgacgtcgagcgtaccaaggcggt	CRISPR spacer
cacactgccactcgacgtcgagcgtaccgagacggt	Protospacer
****************************.**.****

90. spacer 26.1|2441318|38|NZ_CP012069|CRISPRCasFinder matches to position: 1031298-1031335, mismatch: 2, identity: 0.947

ctcgagcgcatttgcccagttgagcctcttttcatagt	CRISPR spacer
ctcgagcgcatttgcccagttgagccactttccatagt	Protospacer
************************** ****.******

91. spacer 26.1|2441318|38|NZ_CP012069|CRISPRCasFinder matches to position: 1854234-1854271, mismatch: 2, identity: 0.947

ctcgagcgcatttgcccagttgagcctcttttcatagt	CRISPR spacer
ctcgagcgcatttgcccagttgaacctctttccatagt	Protospacer
***********************.*******.******

92. spacer 28.1|2529183|38|NZ_CP012069|CRISPRCasFinder matches to position: 452207-452244, mismatch: 2, identity: 0.947

tcgagcacgtttgcccagttgggccactctccatagtg	CRISPR spacer
tcgagcgcgtttgcccagttgggccactcttcatagtg	Protospacer
******.***********************.*******

93. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 1175878-1175915, mismatch: 2, identity: 0.947

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagcgcatttgcccagttgaggcattcttcatagtg	Protospacer
******************************..******

94. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 58117-58154, mismatch: 2, identity: 0.947

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagcgcatctgcccagttgaggcattctccatagtg	Protospacer
**********.********************.******

95. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 208527-208564, mismatch: 2, identity: 0.947

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagcgcatttgcccagttgagccattctccatagtg	Protospacer
*********************** *******.******

96. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 1148110-1148147, mismatch: 2, identity: 0.947

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagcgcatttgcccagttgaggcattttccatagtg	Protospacer
****************************.**.******

97. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 1148536-1148573, mismatch: 2, identity: 0.947

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagcgcatttgcccagttgagccattctccatagtg	Protospacer
*********************** *******.******

98. spacer 30.1|2716475|38|NZ_CP012069|CRISPRCasFinder matches to position: 1213566-1213603, mismatch: 2, identity: 0.947

tcgagcgcatttgcccagttgaggcattctctatagtg	CRISPR spacer
tcgagtgcatttgcccagttgaggcattctccatagtg	Protospacer
*****.*************************.******

99. spacer 7.4|386588|78|NZ_CP012069|PILER-CR matches to position: 386895-386972, mismatch: 18, identity: 0.769

tccacaccacggccgctcatgtacatgaatgcaatcctgtactgcgcccaggcatagccc	CRISPR spacer
tccacaccacggccgctcatgtacatgaatgcaatcctgtactgcgcccaggcatagccc	Protospacer
************************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012069_17	17.1|1365013|30|NZ_CP012069|CRISPRCasFinder	1365013-1365042	30	MN694639	Marine virus AFVG_250M766, complete genome	28502-28531	7	0.767
NZ_CP012069_17	17.1|1365013|30|NZ_CP012069|CRISPRCasFinder	1365013-1365042	30	MN694801	Marine virus AFVG_250M760, complete genome	9369-9398	7	0.767
NZ_CP012069_22	22.25|1962713|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR	1962713-1962746	34	MN694589	Marine virus AFVG_250M1203, complete genome	16837-16870	7	0.794
NZ_CP012069_22	22.7|1961501|34|NZ_CP012069|CRT,CRISPRCasFinder	1961501-1961534	34	NC_006910	Micromonospora rosaria strain SCC2095 plasmid pMR2, complete sequence	9643-9676	10	0.706
NZ_CP012069_22	22.14|1961970|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR	1961970-1962003	34	NZ_CP040720	Rhodococcus pyridinivorans strain YF3 plasmid unnamed1, complete sequence	55022-55055	10	0.706
NZ_CP012069_33	33.1|2775005|35|NZ_CP012069|CRISPRCasFinder	2775005-2775039	35	NC_007949	Polaromonas sp. JS666 plasmid 1, complete sequence	163886-163920	10	0.714
NZ_CP012069_22	22.33|1963250|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR	1963250-1963283	34	NZ_CP013929	Alteromonas mediterranea strain UM8 plasmid pAMEDUM8_300, complete sequence	18751-18784	11	0.676
NZ_CP012069_22	22.33|1963250|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR	1963250-1963283	34	CP013931	Alteromonas mediterranea strain U10 plasmid pAMED10_300, complete sequence	18757-18790	11	0.676
NZ_CP012069_22	22.33|1963250|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR	1963250-1963283	34	NC_019394	Alteromonas mediterranea DE1 plasmid pAMDE1, complete sequence	18774-18807	11	0.676
NZ_CP012069_22	22.33|1963250|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR	1963250-1963283	34	NZ_CP018322	Alteromonas macleodii strain Te101 plasmid pTE101a, complete sequence	20183-20216	11	0.676

1. spacer 17.1|1365013|30|NZ_CP012069|CRISPRCasFinder matches to MN694639 (Marine virus AFVG_250M766, complete genome) position: , mismatch: 7, identity: 0.767

tgggatccaactgggcaaatgtc----tctgcga	CRISPR spacer
ctggatacaactgggcaaatgtcatgttct----	Protospacer
. **** ****************    ***    

2. spacer 17.1|1365013|30|NZ_CP012069|CRISPRCasFinder matches to MN694801 (Marine virus AFVG_250M760, complete genome) position: , mismatch: 7, identity: 0.767

tgggatccaactgggcaaatgtc----tctgcga	CRISPR spacer
ctggatacaactgggcaaatgtcatgttct----	Protospacer
. **** ****************    ***    

3. spacer 22.25|1962713|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR matches to MN694589 (Marine virus AFVG_250M1203, complete genome) position: , mismatch: 7, identity: 0.794

gcgttgagcatgagctgggcttcgtcgatgacaa	CRISPR spacer
ccgttgagcatgagccgggcttcgccgcgaacca	Protospacer
 **************.********.**  .** *

4. spacer 22.7|1961501|34|NZ_CP012069|CRT,CRISPRCasFinder matches to NC_006910 (Micromonospora rosaria strain SCC2095 plasmid pMR2, complete sequence) position: , mismatch: 10, identity: 0.706

ggttaaaggagcttcccgagctgctgtcggttaa	CRISPR spacer
gtggcgagaagctgcccgagctgctgtcggtgcg	Protospacer
*    .**.**** *****************  .

5. spacer 22.14|1961970|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR matches to NZ_CP040720 (Rhodococcus pyridinivorans strain YF3 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.706

gatgacgtactcggaccggagccgtgcgtcgcgc	CRISPR spacer
tccggagagctcgaaccggatccgtgcgtcgcgg	Protospacer
  .*. * .****.****** ************ 

6. spacer 33.1|2775005|35|NZ_CP012069|CRISPRCasFinder matches to NC_007949 (Polaromonas sp. JS666 plasmid 1, complete sequence) position: , mismatch: 10, identity: 0.714

aggagctcaactgggcaaacgtccacaggaaggta	CRISPR spacer
tccatggcgacttggcaaacgtccacatgaaggtt	Protospacer
   *   *.*** ************** ****** 

7. spacer 22.33|1963250|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR matches to NZ_CP013929 (Alteromonas mediterranea strain UM8 plasmid pAMEDUM8_300, complete sequence) position: , mismatch: 11, identity: 0.676

gcgccatagatgatgtgtgcctcatctatcgcga	CRISPR spacer
ctctaatagatgatgtgtgctttatctatgctta	Protospacer
 . . ***************.*.******  . *

8. spacer 22.33|1963250|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR matches to CP013931 (Alteromonas mediterranea strain U10 plasmid pAMED10_300, complete sequence) position: , mismatch: 11, identity: 0.676

gcgccatagatgatgtgtgcctcatctatcgcga	CRISPR spacer
ctctaatagatgatgtgtgctttatctatgctta	Protospacer
 . . ***************.*.******  . *

9. spacer 22.33|1963250|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR matches to NC_019394 (Alteromonas mediterranea DE1 plasmid pAMDE1, complete sequence) position: , mismatch: 11, identity: 0.676

gcgccatagatgatgtgtgcctcatctatcgcga	CRISPR spacer
ctctaatagatgatgtgtgctttatctatgctta	Protospacer
 . . ***************.*.******  . *

10. spacer 22.33|1963250|34|NZ_CP012069|CRT,CRISPRCasFinder,PILER-CR matches to NZ_CP018322 (Alteromonas macleodii strain Te101 plasmid pTE101a, complete sequence) position: , mismatch: 11, identity: 0.676

gcgccatagatgatgtgtgcctcatctatcgcga	CRISPR spacer
ctctaatagatgatgtgtgctttatctatgctta	Protospacer
 . . ***************.*.******  . *

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	44499 : 169886	115	Mycoplasma_phage(11.11%)	transposase,integrase,protease,tail	attL 44351:44410|attR 177277:177299
DBSCAN-SWA_2	946274 : 1016854	58	Staphylococcus_phage(20.0%)	transposase,integrase,protease,tRNA	attL 1001393:1001409|attR 1024890:1024906
DBSCAN-SWA_3	1873337 : 1899481	20	Planktothrix_phage(100.0%)	transposase,integrase	attL 1877076:1877090|attR 1886801:1886815
DBSCAN-SWA_4	1948941 : 1960782	13	Gordonia_phage(25.0%)	capsid,head,transposase,portal,integrase,protease	attL 1957522:1957581|attR 1960819:1960912
DBSCAN-SWA_5	2222725 : 2279035	46	Mycobacterium_phage(50.0%)	transposase,integrase,protease	attL 2236572:2236631|attR 2239940:2240029
DBSCAN-SWA_6	2340091 : 2353324	18	Streptococcus_pyogenes_phage(37.5%)	portal,capsid	NA
DBSCAN-SWA_7	2357394 : 2363439	11	Streptococcus_phage(16.67%)	NA	NA
DBSCAN-SWA_8	2483033 : 2548095	55	Bacillus_phage(25.0%)	transposase,protease	NA
DBSCAN-SWA_9	2839279 : 2845642	13	Staphylococcus_phage(33.33%)	integrase	attL 2837220:2837234|attR 2862703:2862717

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP012069|44499:169886|DBSCAN-SWA
GATGCCGTTCATAAAGGTGCAGAAGCTGGTCAGGGACGAGTCCGGCGCAATCAGGAGCGGGTCCGCCGCCGTGGTCGACACGTCGTACGTGCGCGGCGCCAAGTACCACTCGGCGCAGGCGGTGCGCGAGAGGCTGGGCAAGGTCGTCTGGCTCGCGGACGACAGGCGCTCGGGCGTGTTCGCGTCACCGACGCGCGGCCTGGTGGAGTACGACGCGGACGCCGACGGATTCGCGCCGGTGGCCAAGGGCGACGAGCGGCTGGCGAACACGGGCGCGTTCCCCGAGCCGCCGCGGCACCTGGAGCTCGGCCCCGAGCACCTGCTGCTGTCGTTCCTGGGCGCCGATGGGGTCGCGGGGTGCCTCAGGGAGGCGCTCCCCGACGACCGGTCCTACCAGCGCGCCCTCGCCCACGTCACGCACGGCGTGGTGCGGGACGGGAGCCGCGAGACCTGCGACAACATGGTGGCCAGGTCCTTCGCGGCTCTGGCGCTGCCGGGCGTGCCGCCCGCGTCGCTGAGATCGGACACGGCGTTCTTCTCGGCGATGGGCGCCGACGGGGCGAAGGTCGCGTTCTTCAGGGCGTTCGCCAGGCTCATGAGGAGGACGAAGCCCGGCTTCGGCCGCGCATGCTACGTGGACTCCACCCCGCTCCCGAACGACGCGGTCGACAACCCGCTCAACGCCCTCTGCAGCCACGGGCTGAGGGGCGCGGCGGTCCAGATGCGCCTCGCGCTCGTGCTCGACGAGACGACGGGGCTGCCCGTCTGGTACGAGGTCGTGCCCGGCAACGTACTTGACCTCTCGACCATAAAGACCGTGATGGGCGACGTCCTCGCCACGCTCGGCATCGAGGTCGTAACCGCGGTCCTCGACGCGGGCTACGCGTCGCGCGAGCTGCTCGAGGCCTTCTCCGAGGGCGAGAGGGACGTGCTGGTCAGGATGCCGGCGAGGAGGGGGTACCCGTACCGCGAGCTCTGGCGGGGCGTCCGCTCTCTGATCGGCAAGGGCAAGTACGCGATCACGCGCTCCGGCCACCTCTACTTCGCCAGGAGGCGCGACGTCGAGGTGCAGGGCGTGAGGCTGCACTGCTACGTCTACGTGGACCAGACCAACGCCACGCCGCGCTTCGCCAGGTGGCTGGACAAGAACCAGGAGAGGTTCGACGGGATGTCGCTCGCCGAGAAGGACTGGGAGACCGTGCGGCAGGGCTACTTCGTGCTGATGTCCACCAAGGTCGCGACGCCCCGCGAGATCCTGGACGAGTACTTCTGCCGCACCGAGATCGAGGGCGTCTTCAAGACCAGCAAGGACTACCTGGGCCTGCTGCCGCTGCGCAAGTGGAGCGACCTCACCGTGCGCGGCAAGATCCTCGCCGACATCATCGGCACCATCGTGGTGCTCAGGATGCGCAAGGCGCTCGCCGGGGCCGACGTCTCCCTCACCGAGGTATGGGGCAAGGCCAGGTCGCTGTCCTGCTACACCAACGCCGACGGCAGGGTCGTGGTCGAGACGCCGTCGAGGCAGGTCCGCGAGTACTACAAGGCGCTCGGGGTGAAGGTGCCCTCGTCAATCGACGTCAGGGAATTCGACCGTGACGTCCTCGGCCTGGAGCTGTAGTTCTACAATTAGCGTCATCTAGGGTTAAATAGGCGGTATTTCACTGTTCGACAATGCGATGATCGAACACCAGGAATCTCTTTCGTCTGCGCGGACCCACCAACGAAATGATCGACCGCGCCCCTACATGCCACCCGATGTGTGGGAGGGCCCGCTCTACGTCGTACGGCACGGGTTCTCGCGTGGAATTCTCACGGACGACACCGCGCGCTTTCCCCATGGGGTGGCCGACGGCGTGCCATTCTCGCCCACGATGATGTTTCCCAGGGGCTATGATAGGCTCGCGCTCTAGCGGAACAAGTTCGTCAAGCCTTCCCGCGCGGAATGGGGCGACTGGCGTATGCCGCGAGAGGCCGAGGGCTGCGGCCGCGCCGTGGAAGGCCGTCAGGGAGCCAGGCATGGAGGAGGGGCGTTTTCCCGAGCCATCAAAGCGCTGCAGGGACATCGTAGATCGGAGGCCCGTGGATGACCCTTGAGACAAGACGGCTGGTCCTGCGCCCCTGGGAGGAGGGCGATGCGGAGGACCTGTACAGGTACGCGAGCCATCCCGACGTGGGGCCGATCGCCGGATGGGCCGTCCATGCGAGCGTGGAGTACAGCCGAGAGATCATCAGGGGGGTGCTTTCCGCGCCGGAGAACTACGCCGTGGTCCTCAAGGAGACGGGGCGACCGGTCGGCAGCATCGGGCTGATGCGCGGCGGGGCGAGCAACATCAGCATCCCCGACACGGAGGGTGAGATCGGGTACTGGATCGGCGTTCCGTATTGGGGCCGGGGCCTCATCCCCGAGGCGGTCCGCGAGATGGTGCGGCACGGCTTCGAAGGTCTCGGCCTCGAGAGGATATGGTGCGGCTACTTCGAGGGGAACGTGAAGTCGAGGCGGGTGCAGGAGAAGTGCGGGTTTTGCTACCACCACACGGCGGAGAACGTCCCCTGCGCATTGGAGGGCGTGCTGCGAACGGAGCATATAACCTGCCTCTCGAGGGAAGCATGGCTCTCCGCGAGGGGTGGGCCGGTCCCCGGCGGAGGGGAGGGCTGAGGCAAGGGTGAGAGAGCTGTCCGAGATGTAGCTGGGCGAGCTACCGCTAGACGAGCTGCGGGAGCTTTGCTCTCGTAAAGATCGATATCACCACGGGAGACGAGATAGTTCCCGGTCGCATTTCCCGATCGCATGGAGTACCGCCATCCCTTATGTTCGAAGAGAGTCCGGTGCAGGTGCAAGGACACGCGCGTGCGGCAGTACTTCATGGAGTCCGCGCTGGCCGAAAAGCTCGAGACCGTAGTGACGCGTGGGATCGCCAACACACGCGGACGCGATTACTACGACATACATATACTGGTCCGTCTGAAATCGGAGGAGGTCGACCGACAGCCTCTTCACGAAGCCGTTGTGGCTACCACGTCAAGCGAGGCTCGGTCGAGAAGATGGCTGGCTACACAGCGACACTCGAGGAGGTCCGAGTATCGGGAATCATGCGAGGCGTGGACCTCGTATATCGTAGGGTCGCCTTACGCGGCAGGACCTGACTTCGACGAGATCGTCGGTTCAACCTTCGAGTCCTGCTCTTCGAGTTGAAGAGGATCACACCTACGAGGGTGACCACCCCCGTAATGCACGCAACAATGACTGACTCCATAGAAGGACTGCTCCCTGCACTCGAAGCCGAATCCCCAAGAGGAAGTTTCAAATGGCGTCATAAGGTCGTCCCTGCGACATGTCGTATCGTGCCGCATCGCCACGACGGCGCGAGTCGATGCAAACTCGGCACTCCACGGTGTTCAATTGGGGGCGACGGGGACCATACTTCCAACCATCGAAAGCACAAGTTGCGACCGGAGGGCGGCGAAGTACCACGAGGGCGGCGTCGAGCGGGCGCTGTCGGACGGCGAGGGCGGCAGGGGCACGGTCGGGCGCGAGCGCGGGAGGCTCTGACGCCCCGTCGTCCCTCGCCTCGGCCGACCTGCCGGACGGCGAGGCGATCCTGCTCGCGGGCAAGACGCACGAGGGCCCCGACCACGCCGGGTTTCCCGGGATCACGGGCGGCAGGCGCCTACGGGGAGACCTGACGCGAGTCGTGCCGGCGACGTCTCGGCGTGCATCCCCGCGAAGACGAGGCGCTGCCCGGCGGCCGTGCCGGGCCGCCTCGGGCTCGTGTCCGCGCACGGCTCCCGGCCGGACCTGGTCGAGGGTCTCTTCTCGAGGACGGCCCGCCGGACGCTGCGCAGCATCCGGATGTCCAGCAAGGACGAGCCCGAGGAGAGGATCCTGCGCTACCTCGGGGAAGTGAGCGCCGAGCCGGTCGCCCACGGGTGTGGCGAGACCTATCGGACGTCGACCCGACGGCCAAGGGCCCGTCCTGGACACCCTCCTTTCGGATGGGACAGACAAGATAGGTTAGTTGCTGGATGTTATGCTAGCGCAAGGTTCGGTCGTCGGCAGAATTAGACCAGTCACTCACACTGCATTGAAATATGTGAGCTTGTAGTGTAAACTGACCTCGGTGATGAACGATGCTCTACGGATATGATGACATGCTCGCCCGCTACGGCTCTGCCTACCAGATTGGCAAGGCGGTCGACTCTGGCGCTGTCTTCAAGATCGCCCGCGGACTCTATTCGGACGAGCGGCATCCCGACCCGAACGCCGTTGTCTGCGCGCTCTACCCGCAGACGGTTCTTACTATGGACTCGGCCTTCTACCTGCACGGGCTGACCGACGTGGTTCCCGAGATGGTGCATGTTGCCACGGCGCGCAACTCGACCCGAATCAAGGACGCGCGCGTGCGGCAGTACTTCATGGAGTCCGCGCTGATGGTGGCCGGGGTGGAGATGACAGGTGATGGCGGTTCGACCGTCCGCCTGTTCTCGCGCGAGCGCATGCTAGTGGAGCTGCTGCGATGTGCGGGCTCGATGCCCCTAGACTACTACAAGGAGCTTATCGTTTCGTATCGCAAGATTGTGGGTGACCTGGACATGAGGGAAGTCGAGGACTGTATGGCGCTCTACAGGCGCGCGGACAGCCTCTTCGACATGATGCAGAGGGAGGTGCTGTAGAGATGGACCTCCGTCAGATTCGAGACGTCTACATCGACGACGGGCTTGACTTCCAGAACGCCACGGCGCGCACCTGCCGCGACGTGGTGCTCACGCTGATCTCGGCATCGCGCATGGCCGACCACGTGACGGTGAAGGGCGGCGTGGTGATGCAGCAGATATCGGGCGACGGGAGGCGGGCCACGCGCGACATCGACCTCGACTTCGTGCGCTACCCCATGACCGACGAGGGCATCAGGGCTTTCATCCGCACCCTCTGCCCGGCGGACATAGACGTGCGCCTTGAGATCGTCGGCCCCATAGATGACCTCAAACACCAGGGCTACCACGGCAAGCGCGTCTACCTTCGCGTCACGGACTCCACCGGCACGAGCATGGAGACGAAGCTCGACCTGGGCGTTCACGACAAGCTACCGCTCGAGCAGTTGGAACTCTGGTTCGACACGGCGCTGCAGGACGAGGGCGTCGCTCTCATGGCCAACTCAAAGGAGCAGGTCTGCGCCGAGAAGCTGCGCTCGCTCATGCGCATCGGCGCGGCGTCCACGCGCTTCAAGGACGTCTTCGACGTGTACTACCTGCTCTGCCGTGAGGGGGTGGATGCGGATGCCCCCGACCGGGCCATGCGCGTGCTGGTCTACGACGCCGACCCACTGCTTGGCGAGAGAGGCGGATGTTCTCCTCGAACGGCAGGGCGGCGCCGTCGATCATGGTGGAAGTGAAGCCGGCGTTCACGGCCTGGCGTACGTCGCCAAGCGTCTTGCCATGGTCCAGGTGCGGTGTTATGGGCACGGTGTAGCCATTGATGGCGCGCTGAGCGGTATTGGCGATGTACTCGTAGTCGGTGACCTGATATTCGTGGGCGCGAATGTCTTGGGTTGCGCGTGGATGGCTCGCGCTTCCCTGTGATGCCTGTGGCAGGGTTGCTGGGCCTGTACGTATGTGGCGCATGGGCAGCCTACGCGTCGCCATGTCTCGGCAGTGGGATGGCCCCGAAACTCCCGCGCGCCCTTGCGTCTTGCGAGGTACGCCTGGCATACCATGAGCATAAGACTCATCACGGACGGCGTGATGGGCAGAGGCGACCAGCCCAGGATCATTTTGCTGAGCGCGTCGGGCACGAAAAGCGCCATACCCAGCATCGCTCTTGCCATGCGACCGATGCCGGTCGCCGCCCCGCCCGTCAGGGCCCACGCCTGGGCTCCCAAGAGCCTGGTGACACGCCTGCACGAAGACGCGCTCTCGATGAGGTCGGAAATCTATCCCACAGGCTGGGGCGACATCCTCGCCCATGTCCTTGAGCCGGAACAGCAGGAAAGACAGGTCATCTGCCCTCCCTTCGCCACCCAGTGGGTCCTCGGCCAGAGGCGTCGCATCCCGAGAGAAGATGGACGTGACAACTCCCATGAAGCTATCACGCCTGTCGTTGGGAAGGGTCCCGGGGACCCCTTAGCCTACGCTTCTCAGAACCGTCTTAGCTCCTCGTGAGCAGCGTTGCGATCGCATCGAACGTGTTGCCGCTGCGGATGGTCAGCAGCGGATAGAAGTCCTCTCGCATGAGCAGCCTGTGGTATGCGGTCCTCAGGTACTCTGACTCGCTAAACTTGCCCCAGAACACCACGTGCCTCCCAAAATGTATCGCCTCGTCGCCCAGCGGCATGGACTTGATGCGTCGACGTGCATGCTGTGCGTCTATCTCACGTGTGAAGAACAGCACGTCGCGGCGGGCGATCGGCTCGCTCCACCACGTCGGCAGGTCGGGGACCTCAGACAGGTAGTCTTCCCGAGACAGGATCGCAAGGCGGATGGGAAAGGGGTAGCGCTCCTTGAGCATGGCCGCAAAGGCGCGGGAGATCTCAGACTCAGGCACATCGGTCTCGAACAGCACGTTGCCGCTGTTGATGTACGAGCGGACATCGGCGCACCCCATGTCTTCGACCTGCCTGCGAAGCTCGTCCATGATGACCTTGTTCTTGCCGCCGACGTTGATGCCGCGTAGCAATGCCACGTATTCCATCTTCACCCTCGAGTCTCGACCGGTCCCGCGCTCTGATTATCCCATGACCTCCTGCAACAACCTGGCATCAGAAAAGCTCCACGACCTCCTTGGCGTGCGCGCGGTCATGCTGGGTGGCGGAGACGCCCTCAATTGACCGTTCAGAGGGACTGGTCTGTGCGGCGAGCTGGGCCGCATCATGGCGGCCGCCGCAGATGGCATGTTCGATACGCCGGCGGTGTTCTCGAGTCGCAAAAGTCTCGCCAGCTGCGGGCAGGTGGGCTGCAACTTGACTGTCGTCGAGGCAAGAGAATATGGATGCGCATGGCTCCATTGCAAAGTGAGCAACGCGAGGGAGAGATGGGCGAGCATGACGTAGGTGTCGATCACCCAGTGGTACACTCTCGAGAAGAGCGGGTGAGCCCGCATGCATGCGAGGGGCGTGGTGGCCGTCGGGAACATGCCATTCCCGTCTGCGGCCCTTCGCGGATGGCTTCAAAGAGAGGATTGACCGCCATGGTTTCTGATGCGTCGCTGGCCTGCATGGTCGTTGCGGCTGTGATCTCGTTTGGCGCGCCGGTCGTGGCGCTCGTCGTTGCGAGAAGACGACTGCACGTCCAGTTTAGGGCGGTTCTCGTCGGCGTGCTGGTGTTCGTTGTCTTTGCGGGCTTTCTCGAGCAGCTTGTCCATGCGTTGGCGTTTTCCGCGTTTCCGGGCCTGAGATTCACGCCGGTCGCCTTTGTCCCGTACGCCGCCCTTGCCGCGGGCGTGTTCGAGGAGCTAGGGCGCAGCTGCGGGTTCATGCTTCTGCTACGGTCTGGGAAGGCGGATCACGACCTGCCCTGTGCCATCGGATACGGTATCGGCCATGGGGGGATCGAGGCTATGCTGATAGTGGGCTTGTCGATGGTATCGAACATAGCTCTCGCGCTTGCGCTCAATAGCGTCGGTGGCGCTGACGCGTTGCTCGCGACCGTGCCCGACGCCTCGCGTGTACTTGTCGCCCAACAGATAGACGCCCTCATCGGAATCGCCCCGACGGTATACCTGATTGCTGGGTTCGAGCGCATCGTCTCGATGGCGCTGCATGTCGCGCTGTCTGTCCTGGTATGGATGGCGGTCAGCGGTAGGATCGGCAAGGCCTGGATATTCGGGGCGGTGTTGCTGCATGCGCTTGCGGATGGCGGGGCGGCACTCTATCAGCAAGGGATGATGCTTCTGCCGGTGAGCGAGCTATGGGCGCTTATCGCGACCGTTGCGACGGCGCTATTGGTCATCCGGCTGTACGCGGGACATGGATGCCATAGCGACGGAACTGCCTAGCGTGGATTCGACGTCATGGGATCTTGATCCCTCGCCTCACATCGATGATGGGGATGCTCGCAGTGGCGGAAGGCGTCCCCGTGGCGGGCGGGCGTGCTGTCTTCCCACGCGCCCATTCGGATGAGGAGCGCATCGGTGCGCGGGGACGCCCCTGCCGGGCGCACGGCAAAGAGCATGTCCAATGAGGTCGCGTCGTCAGTCTCTACCTGTGTTGGGACCTTGGCCTGTCGGACGCCATGGCCCTGTAGCGTCGTTAGGGTCGATGGGTTTTAGCCCGGTGATGAGGTTGGCCGGTCTCCCCCTGCCTCAAGCAGAGTGAGACCGGCGGGATCTATGCTGAGCTTCTCACGGAGGGCCTTCAACTTCTTTTGTACCGACATCGCTCGCCAACTCCCGTTGGCCCCGCAGCAGGCCGCTTCTCTCTTGGACCCGACTCAGCCGCGCTTCCAAAGCTCGTAGGTCCGGTTCTTGGTTGTGCCCGAGGAGGATATCAGGCCGCTGGCTTCCAGGCGACCTGCTATGTCACGGAGCGTGCGCACTGGGATGTTGAGCGCGGCGGATATCTCACGCGGGGACGAGGGACCGTGAGCTGACAGGTACTCGCACACGCTCCTGTCGCTTGTCGGTAGGGCGAGCCAGTCGGAAGCCCTGTCGTTTCCGGCGGATTCCGGCGGATTCCGGCGGATTCCGGCGGATTTTGGCGGATTGCCGGTATCGCCGGCGAAGGGTCCAAGGCGCCCGACACCGTCTAGGGCCTCCTGGCGCGTGAACTTCACGTGGACGCTGCTGGCGCGCTCGAAGACCTCGACGGGCGTGCCCTGCGCCTCGCAGGAGCGCCTGATGCGCTGCAGTCCCGTGCCGTAGGACTCGATGTCTCCGGAACGGTAGAGCGTCTGGGCGATGAGCACGTTACGTGGGTTCGATGCCGCCGACCTGCCGGCAAGAAAGTCGTCGGGCAAGACTCCGGGTGGAAAGGGACCCGGACTGTAGATGTCGACGCTATCCCAGAAGATGTCGATCTGGACGGCGGCGTTCGTCTCATAGACGCGATGACTGAAGGCATTGTAGAGTGCCTCGCGGATCGCGTCCAGGGGGATCTCGGGCACCTCCCTGCGCTGCAGTGACACGCTTGCGTCGATGACAAACGCGCGGCGAATGTTGTTCACGATGTAGGTCTCCCCGGCGTCCACGAGCGAGAACAGCGGCCCCGAGACCTGCTGGTTGTCGAGGATGTTCACGCGGTCGCTGTCTGCGAGCACTCCCATGCGCAAGCCTACCTGGGACCTGTCTGTGAAGCAGACCATAGCCGCGTTCGTCAGCGTCTCATCCTCGCAGAGTAGCCCGAGGCGCGAGAGCACGTCGCGAGCGTCGGTGTACTGGAACGGGATCCGCTTGGCCTGTACGCCCCGCGCGACATACCTGCGCAGCACCTCCTCGTCGACGGCGGAGACGGGCTTGCCCGAGCTGCGGCCATCCCAGGGGTCCCTCCCGGCCGCGCGCTCCAGTATCATGTCCTTGAGCGCGGACGCGCTCATAGGGACGTCCTCGTCGGCGCTGCGGATGCGGTATCTGCCGTCGCACGCGTAGGGACGCTCGCCTCCGGAGAACGTCACCTTGACGTACGCCCTGCTGTCCGGGGTCTCCAGGCGCTCAATCTGCGGGTAGATCCTGGGCTCGATGCGGTTACCAACGGCTTGGCTCACATCGCGCAGCGTCTTGTCGCTCACATCCTGGCCGACGACCTCTCCGTCGTTGCGCACGCCAAAGTAGAGCGTGCCGTGGCCGTGCTTGTTGAGGATGGAGGCGATTGACTCCATGCCCTCGCGCATCTCGCCCGTCGACCTCTTGTGTTCTGTGCGCTCGTCCTCCATGCCGAGGTTCACAGGCGTCCTCCTTCCCACTGCCGGTTATATTCTACGAAGGGCACTGTGCCAGTCGGGTCTCGCCCCATCAGTAGGACTGGGCGGGGATCGCCCTGCTCGTCGATGTCGGAGCGACTGCGGACCGTAAGCTCCCTGTGCTTGTAGGGTCCTATCGCTTGAGGGCTCTGCCCATTGACCGTGAACTCGCTTATGGCGTGCGCCGCAATGCCGTACTCCAGAAGCTTACTTCCTACCCCCTTGCCACGTTCGTCTGCGACGACAAACAGCATCATAAGCTTATGGCCGTCGATGTCCGTGAATCCCCAGAGACGCTTCGCCTCCTCCTCTGCTATGACGAAGCGCAAGGCGCTCTTGAGAGCAAGCGGCATGTATGCCAGAATAGCCTTGATCCCAAGATGCAGGAGAAACAGCTGAGTCGTCCTTACCGATCTCTCCCATACGTCGAGGAGCCGCTTGATCGATTTGGGAGTTCGCTTCCCACGGGCAACCACTCGCATAGGCTGCTGTCCTCTTTGCTACGACGTCCCTGTCGAGCGCGCTTCAAAATGACACTCGGTGCATACTATTGCTCACTGAAGTGATCGAGGCGACCTGGGAGTTGTGTTTTCATCACTCAAATAGTGGCTTCAATCTGGTTTTGCTCAGTCGCAACGATACAGCTTTCATAGTAGCCATCTCCGGTTGTCCTTGGTCCACTGACAAGCTCATATCCGCTTGCCCTCAGCTTGGTAGTCAAGGCATCTATCCTCTCCTTACTCCCAACACTAAGGAGCGATATGTGAGCATCATCCCGTACGGGCAGGCCCTCTCAGCGGATCGGCCATCCCCGACTTACTCATAAGCTCAGCACGTGCCATCGTCGAACGAGAATGCTCAATTCTCACGCTTGCCTTCACACATGCCGCAGGCGCGCACTGACGCCGGGCCCTCACGGAAGGGCACGGTTTGCCGGCGTCACATCCTGCAGTGCCACGCCACGGGCGGTCCCGACGCACGGAGGCGCTCACCCCTCTGTGTCGCCAAGGCGCCAGAAATTCTCGAGAAAGCAGTTGACAACTACTACGGGTGACGATATATTGTTCCCAACGATATATCGTAGTCCGGTATAACGAGAGGCGTAAGGGAGGAGACGCACATGCCGAGGAGGGAAGAGGCCGGCGCGCTGACGGAGCCGACGTTCTACATCCTGCTGTCCCTGCACAGGCCCACGCACGGATACGCGATCATGCAGGACGTGCGGGAGCTGACGGGCGGACGGGTGAACATCGGGGCGGGCACGCTCTACGGTGCCATAAGCTCGCTCACCGAGAAGGGTTGGATACGCGCCGCGGAGGGTCACGCGGACGGCGGCCGCGCGTCCGAGCGCAGGAAGGCGTACGTGATCACCGAGGGAGGCAGGCGGGCCTTCGCGTGTGAGGTCGAGCGGCTGGAGAGCCTTGTCGCCGACGCGAGATCCGTTATCGAGCAATGATCACGGGCGGTACGCATATCACATCCGCACATACACCACGTTCACAAAGGGAGATCGACATGAGCGCAAGCACAACCATCAAGAGGGCTTTCACCGACTTCTCGAAGGAAGAGGCCTGGCTCAACCAGATGAGCCACGAGGGCAAGGCCCTCGTCGACTACCGGGGCGGGAGGTACACCTTCGTCGACGACGAGCCGGGTGCCTGGCAGTACGCGATCGAGGTCCTCGGCCGGACCGGCAGGGCCGGCAGGGAGTACCTCTCCTTCCTCGAGGAGACGGGCGTCGAGACCGTGGCCGTCTACGCGAACCGCGCCTACCTGCGCAGGAGGGACGACGGGACCGACTTCGAGCTCCACAGCGACCTCGAGTCCCGCCTCGAGCAGGCCAGGAGGGGGAGCGTGCCCTGGATGGCCATCCCGGTGTCGCAGGTCGGCGTCGCGTTCACCCTCGTCCTCAACGCCTTCGTGGTGGACTCCGGGGCGTCGAACCTCGCCAGGGGCATCGTCCTCGCGTGCGCCACCCTGCTCGTCTTCGCGGCCATAGTCGAGTACCTCGTCTTCGGCAGGCCGTATCGCGAGCGCGTCCGCCAGCTCGAGCGGGAGCGCTCGATCAGGGAGTAGCGGGCGCGGCCCCCCGGGCCCGCCCTCGCCGTTCGCGGCACCCACTTGGGCCGGACTCCCTCACCCAGATCTAAATAATGTTTATTAGTGTTGCATTATGTTAAGACGAGAGCTATACTCCACCTAAAGAAGCGGAAGGGAGGGGGGTGCTGATGGGTGGCGCCCACACATGGACGGAGTGCCTGGGCGACGAGGATCTGGAGTTCGCGCGGGACGACGATGCCTTCGTTTCGCTCGTGAAGGGCATGGCCATCGACGACCGCATGGACTTCGAGGCCGCACGGCAGATCATAGACGCCCACAGGCAGCTGATGGGCAGGAGGGGGGATGGGAATGAGTGTGGACGGCGATGTCGCCAGGATGTCCATCGTGTGTATCGGTTTGGCGCTTGGTACGCTCGAGTGGTTCATCGTCAGGAGGACGAGCTTCAACAAGTGGGTCGTGCCGGCGGTGTACTGGGTGGGAGCGCTGATATGGTCATCTGCGACTGGACCTACGCCGGTGCTCTTCCCGAGCCTGGCGATGGGCCTCTCCATGGCGGGCTGTGCCATCGAGGACGAGATAATCAACAGATATCTACAAAGGAGAGGCACATCCGGCGTCGACAAGGCGAGGCTCCGGGACCTGTAGCGGGGGTGCGGCTACGCTCGGAAGTGGGGGTCAGTGCCATCGCGCTGGCCCCCATCCTCCTGGACTTGCCACCGCCCTTCTTGCGGCATGCCGCCCGCGACAGGCACCAAGTACGACGGCGCCCCGCAAGCGGAGGGAACCGAGCCTCCGTCAGCCGCCCCTGCGCCATGAGGCTGATAGGGGGTATCATTGGCCACGTTGGGTCATCGGCCCCATATCGATCCCATACCTTGAGGCTCTTCGCGGTTTTTGGTGGGTATCACGGGCTAGGGCGGAGCGCAGGCGAGGGCGTCGAGCGACAGGCCCCCAGCCCGGGGAAGATTGCGGTGGCGAGAGCCCCGCGTCGCGAACCCCCCGGCGGCCCCCTTGACGGGCGGTGTGAGCGGGTTGGCCCCCCGAGGTGGGCCGACGGCATCCCCGGCGGGCCCCCGCTCGCTTGCGCTCGCGCGTGGCGGTCGACTCAGGCCGCCGCTGACAGCGATTCGCCTTTGCACCCCGCTGTTCCGGCCCGCGACCCCCCTCGCCGGCCCCTTGGCTGGCCCCCCGTTCGACGTGCGAGAACGCACGCGTCATCGCGACAACGCAGCTGCGCTCCTGGTCTGGGGCTGCGGCGGGACGGCTGGGGGCCTGACATGGCGACTAAGCGCAAGGCTCTGGTTGACGGCGAAGGGGATGACGAGGGGAGCGCGTCCGATGCTGAGCCGGGGGCGGATGACTGTGCCTTGCAGCGTGAGGGCGGCTGGCATGCGGGCGGCGAGGTCTTAGGGACGTCAAACCCGGGCGACTGCCCCTATGGCCCTGGCGATTGCCCAAGCATCGAAGTGGTTGGGTCCGAAACGGGCTGGAGGCGGCGACCGTGCGCCCGGCGTAGACCCCCGCACGGCCTGTCCGGGCGCGGTTTCGAGGACGACCGAGTGCGTCCCCAGGGAAGCGTTGCGTTTCCGTGACGCCGCAGTCGCAGAGTGCGCTTTTCCGTCACGTCGCGGCGCCCGGGAGGTGTGGGGCAACCCCCCGCCAGGCTGCGGGGCACTATGGAGAATGCCTCAACTGGGCAGATGCGCTCGAGCAACCCCCCGCCGGGCTGCGGGGCGGGTTGCGCGGGGGTCCGCAGATCTCGGTTCGGCGTCGGACCTCACGGAAAGGCGCATTCTGCGCGTCGGACCTCACGTAAAACCGCACTCTGGGGGTGTCGCCCTCACGGAGAAGTGCACTCTGTACGCCGGACCTCACGTAAAACCGCATTCTGCGCGTCGGACCTCACGGAAAGGCGCAGTGTGCGTGGCTGCCCGCACACAGAGTGCGCTTTTTGGTGAGACGCGCAGACAGAATGCGCTTTTCCGTGAGGCGGCGCCGCGTTTGCCCAGGTGAGGAAAAGCGCACTCTACGGAAAGGCGCATTCTGGCTGCATGCCCTCACGGAAAACCGCATTCTGGGGGGTGTCACCTTCGCGGAAAGGTGCGCCCCGCGCCGGCGACGCCATCGCGACGTGACCAAAGGGCGTATCCTGGATGGACGGGCGACGCTTTGAAAAACGAGGGAAGGGTATCGGGATGTGCGAGGAGTGCTACGTTGACGAGAGCCGGGCGACCCCGCTGCTGAGGCCACGGGACTGCCTGGAGAGCCACACACAGTACGTCTGCGGGACCTGCGGCAGGTGCATCTGTATCGAGCATGACCCCAGGCGCGGGCTGCGGCGGTGGAACTTCCCCTTCAGGTCATTGGAGATCGCGAAGCTGTACCTGCGCGCCGCGGACTACAGCATGAAGAGGCCGTGTGGCATCTACGAGATGGAAGGCGCGGGCGGCAGGCTCTCGTACAAGATCTTCGCGGACGGCGAGGACCTCAGGCTCTATCTGGGGAGGAACAAAGGGAAGGCGTGTAAGGGGATGGCCCCCGCCCTCATCGTCGGCGAGTACAGGGAGTACGCGGGCACGCAGGTGCGGAGGCTGTCCCCCGACGAGGTCGAGAGGTACCTGTCGGAGCGCTAGGCCCGCCTCGGGGAGGCGGGAGGCCCGGCTGCCGGGCGCCGCCGTCCGCCTCCCGGGGGCGAGACGGCCCCCGGCGGCCCCGGCCTGCCTCGCCGTCGAGACCCGACGGTCTCGACGGCGGTCTGCCATGTCGGCTCACAATGTCTATTCGCGGCTACGTCGCAAGGCTGCGGGCGTTCGCCTCCAGCCACCCCTGCAGTTCATCGAAGCTGTATCCGCCCTTCAGGGCAATGCCCTCCCTCACGTCGGAGGTGGCGCATTCCCTCCTGTAGTCTTCGAGCATGTGACCGAATCCTCCGCCACCGTGCGTGCAGAATGGGATGATCGTCTTCCCGCTCAAGTCCACCGATCTCAAAAATGAAAGAACGGGAGGCGCAAAAGTCCTAAGCCAATTAGGGGAACCTATGAAGATCGTCTCCGCGTCGCCGACGCTCTCCACCCCTCGACGTAGCGGTGGGCAGTATCCCTTTTCAATCTGAGCCCTGACTTCCTTCACCGCCGTGTTGTACGAAAAGGAGTACGGCTCTTCGGGTTCGATCTCTCTCAAGTCCCCGTCCGTAATGAGTGCGATGTCCTCGGCCAGTCCCTTCGTTATACCTGAATACGAGTAATACACGATCAGAGGATTCATGCGGGGAGTCTCCTATCGGTCGATTAGCGCTATGTCGTGCCCACCTGCCTCTTGTACCCTAGGCTCCCGAATGGAATGATCACTCGAGTGGAATCCCCACATACGGGGGTGCCTTGAGGCGATAGGGGCTCTCCGACACGGATGATGGCAGGGCAAGACATCCAAGACAAGGCGTTTCGTTGCGTCTGGATGCGAGGTCGCCCCGGAAAGCTGACGTCAGCTCCGGATGGGGTAGACTCGTACGTTGCATGATCCATGAGGCGTTCCCGCCACATGTGCCGGAGATGGAAGCAGCCCTCCTGTTGGGTGCTCGTGGAGTGCGCTTGCACGCTGTGGCGTCAGTAACCTGCCTCCTGGGTTGTTCCTTCTCCTTACGACGCGCATGCAAAGAAGGGGAGGCCATGCAAGGATCCCATGTGTCCGCTACCCTTACCGTCTGCCATGATGGGCAGTTCTGGGTGGGGGCGTCCACCAAGGCCCAGCAAGCACCGTCTTGTCAGCTCGAGGCCACGAAGGAGGACCGCAAGGCATCGGCAAGAGAGAGACGCGAGGAGGACAGGCGGGGATGGCTTGGGCGGCGGACCCAAAAGCGCAAGCGAAGGTATCGCGGACACCGAGCGACTCCGAAGGCTCCCAAGCGAGCGCCCCATCCATGAGGCGGAGTACCCCACCCATGGGGCGCTAACCGAGGCCCCATGCCTCATGCCCTATGGCTGCAACGTTTTCTGTAGCAGTGCCTCTGACCTGCGGGGCGCAACCGTTGGGCGCATTGCAAGTTCCGCAAAATGCAGCCGTGGATTGGTGGGATTTTGCTCCTCGCTACCGTAATGTAGTCATTGCCGGGGTACGCAAGACAGCCCCATTCGCACCAGTCTCTGACGATGAAAGGACACAGGATGAGCTTTCGTGACAACCTCCAACACCTGCGTGCCACGCGTAACATGACCCAAGAACAACTCGCCATGCTCATGGGTGTGAGCCGCCAATCCGTGACAAAGTGGGAGGCCGAAAAGGCCTATCCCGAGATGGACAAGCTACTCAAGCTGCGTGACATCTTTGGGTGCACGCTTGACGAGCTCGTGCAAGGCGACCTTACCACCCGACCGAAGGAGCCCGGCTTGGGTATTGCGGAGGGACCCGCCCAGGACGTGTGCGGCTATGAAGAGCACATGCGCCAGCACGCACGGAACATGGCCGTGGGCATTCCGCTCATCATCCTGGGGATGGCCGGGGCCGCCTTCTTCGGGGAACTGGGTCACAACATGCTCCCTATCGACAACGACGCGCTCTCCGGTCTGGTATTCCTTGCCCTCACCCTCGTCGGGCTCTGTTTCATCATCCCGGCGGGCCTCAGGCACGACGCGTTCGCCAAGGCGCACCCGTACGTAGAGGACTTCTACACCGCAACCCAGAGGGAGGCAGCCAACCGACTCTTTTCCCGCGGCATCGTTGGGGGCATCGTGGCCATCTTCGTGGGCCTCATGCTTGCTGTCGGCCTCGACGACAGCGTCTTCTGGACTGGAAGCGCCTTTCTCGCCTGCGTGGCGGTGGGCGTCGCGTTGCTTGTCTACGCGTCACTCATGCATGACCGCATCAACGTGGACGAGTACAACAATGCCGCTTTGGAGAACCTCTCCGATGACGAGATTCGCGAGCTGGGCGCGGGTGACGCCGACGCGCTCGTGATACAAAAGCATCGTAGCGCCCGACTTGGGGCCACCTGTGGCATCATCATGCTCGTTGTCACGGCGATTGCCCTGTCGCTCCTGTTCCTCTCTCCCTACCTTGGGACGGCCAGCGCCGCAGCGTCGTCGTTCTTCTGGCTCCCATGGCTCATCGGTGGCCTGGCCTGTGGCATTGTCAGCCTCATCTACAACATGAGGGGTTAGGCCTGCGCTGGGCTCCGCAAGCGAACGGTCCTCTCGTTGGACCGTCCGGAGAGCCTCGGGCGGCGTCTCGGCGCACTCGGCCGTCTCGCCGTCCTGAGCCCTCCGCCCCGCCCCCGCCCTACGAGAAGATACCGTGCATGAACTGGCGCACCGTCGCCTTGGCCTGCTCGTCGTCCAACCGTCCCTTGCCTTGGTGCCAGAATGCGACGTCGGCGTTGAGCATCGCGACGAAGTGGGCCGCACAGGAAAGCTCCCGGCCGCGAACGCCCCCGTGGAACGTGGCAATGCCGCGAAATAAGCGGGTGACGATGGCGTACTGTTCGTGCGCGTACGGCTTTGCCATCCTGGCCACCGCAGAGTCGGGCGGCGCAAAGGACAAAGACAGCCTGAGGAGGTAGAACTCGCTGTCCTCCTGCGCGGCGGAGTAGTAGAGGCGTGCCACGCGCAGCAGGGCAGGCCGCACGTCGCGCCCGTACTCATGCGGGTGCGGCTCGTAGGCGCAGGCCGCGCCCAGAGCGCGGTTGAACGCGGCATAGCGCTCCTCAAGCACGGCCGAGAGCAGCCCCTCCTTGCTGTGGAAGAAGTAGTACAGCGTCGGCTTGGTGACGCCTGCCGCCTCAGCGACCTGCGCGACGCCGACGCCGTCATAGCCCCGTCGCGAGAACAGCCCCAGGGCGCAACGTAGGATGGCATCTCTGCTGTTGGTTTCATTTCCCATGGGAGCAGTATATATCGAGAGGGGCGTCGATATATCGAGAGGGGTGTTGCTCGCGTCGTGTCGGCGACCGACCGGTCGGCGAAAGCCTGCGGCGGCACCAATCCCGAATCTTGACTCCCATATACCGTGCGGTATACTATCTACCGAACGGTATAGACCGAAGTCTGGGAGGCTGTTATGGACAATGGCATCGACATGGGTATCGTGTGGTGGCAGGTGTACCCGCTGGGATTCTGCGGAGCTTCCGTGCGTCCCACCTCGGAGGGGGAGCGCACGCTGACACCCCGGCTCGACCGACTGGGTGCATGGCTGGACTACGCCGTCGACATGGGTGTAGGTGGGCTGATGCTCAACCCGCTGTTCGCCTCTGAGACCCATGGGTATGATACGACCGACTACTTTCGCATCGACCCACGCCTCGGCGACGACGCAAGCTTCGACCGCCTCGTCGCCGCCTGCCATGAGCGGGGGCTGCGCGTGATGCTCGACGGCGTGTTCAACCACGTGGGACGCAGCCACCCGCTATTCCAGGACGCCCTCGCCGGACGGGGGAACGAGGACCTGTTCTCCATTACGCGCCGACCCGACGGATCTGCCGACTACGCGACGTTCGAGGGCTTCCGAGAGCTTCCGGCGCTCAACCACGACTCTGGGCGGGTCGCTGGCCTCGTGCGAGACGTCATGCTCCATTGGATGCGACGCGGCGTCTCGGCGTGGCGTCTCGACGCGGCGTACGCCGTGCCGCCCGCCTTCTGGGCGTGCGTCCTGCCCGAGCTGCGGAACACGTTTCCCGATGCCTGGTTCGTGGGGGAGGTGATCCACGGCGACTACGCAAGTATCGTGCGGCAGTCCGGGATGGATGCGGTGACGCAGTACGAGCTGTGGAAGGCCGTCTGGAGCTCGCTCAAGGACGGCAACTTCTTTGAACTCGACTGGTGCCTCAAGCGACACAATGGCCTCATGAGGACCTTCGTGCCGCTCACCTTCATAGGCAACCATGACGTCACGCGCATAGCCAGCATGGTCGGCAGTGAGCTGGCCGCCTTGGGGGCGACCATCCTGCTCACCGTGGGCGGCGTCCCATCCGTCTACTATGGCGACGAGCAGGCGCTGCGCGGCACCAAGAGGAAGGGGTTGGGCGGCGACGATGCGGTGCGTCCCACCTTCCCCGCCTCCCCAGCCTGGATGACGGCGGAGGGGGAGCGGACATACCGCCTATATCATGACCTCATCGACCTGCGCAGGAGGAATCCCTGGCTCGCCCGCGCCACCACACGTCCCACCCGCCTCGCAAATCGCAGCTACTCCTACGATGCGAGTGGCCGTGGGGGAGAGGCCCTGCATGTGGACCTGCGTCTTGACCCGACGCCGCATGCGACGATCAGCTTGCGCGGCAAGGTCATCCTCGAGGTGGGCCACTGAGGCGGGTGGCAGGCAGCTTTCTGGGGATACCCTAAAGCGCCGTGCCCCTCTTCGGGCGCCAGAACCCGTCTCTCATGGCCCCCTCGTGCTCCAGCAGCCTCACCTTCGTGTCGATGCCGCCACCGAAGCCGGTGAGGCTGCCGTTCGACCCTATCACGCGGTGACACGGCACAATGAGGCAGAGCGGGTTGCGGCCGACCGCCCCGCCCACGGCCCGTGCCGACTGTCGCCTGCCGGTCTCGGCCTCAAGGCGCTTGGCGATTGCTCCGTAGGTGGTCGTCTGCCCGTAGGGTATGTCGAGCATGGCCTCGCGTACGCGCAGCTGGAACTCGGTGGCTCGTGCCGTGAGCGTCAGCTCGCGCGGGTCGGGCGTCTCACCCGCAAAGTAGCGATCGAGCCACCTCCGTACCCGGTCGAACACAGCCAGGCTGTCGCTGCGCTCCATGCTCTCGTTTACTCCGTAGCCGAAGTAACGGCCGTTGTTAAACCAGCAGCCCGTGACGCCCGTGCCGTCGCTCGCGAGTGTGAGCGTGCCTATGGTCGGCGTGCGATATTCCGTGAGGTACATCGCGACTTCCTTTCGCTGGTGTCGCAGGTCGCGCCGCCTTTGGCTCGCCTACAGCCCGCGCGTCTTCAGGTCGGCGACGAGCTGCACGTAGAACTCGCGCACGTCGAACCCCGGGATATTCTCTCTGTTGAGGTCGACCACGTCGCCGTGACTGATGCCCCGCCTTCCCTCGACCGTCAGGAAGCGATACGAGTCGCCCCAGGCAAACGATCTTTCGCCCACGAGCCCGTCGTTCGGGCCGTCGAAGCATTTGGCCAAAAGATAGGTGAGGTTGAGCGGGAACGTGCCCGAGGCGGCCCCGTTCAGCCTCGAGCCGACGCTCGCGCACCACACCCCCTCGACCGTCTGAGGCAGTTCTCTGTTCAGGAGGGTCGTGCCTGACGCGGTGAGGTCGCCCACCGCTGCGATGAAGTTGGGAGCCGGATCTCCCAGGGCGTGGGCTGCGGCATTGTAGCTTCGTGCGATCGCTTGCTGCTGCTCGTTTGACATGACGTTAAGCAGGTAGTCCGCGAACTCGCAGCCCCTGTGGGGCGTGTTGATGGTGGTGAGGGACGCTACGTGGGCCTTTACCTGCGGGTCGGCGAGCGCGACGCGGCAGTCTAGGCCTCCCTTGGAGTGCCCTATGAGGTTGACCTTCTCGGTGCCCGTCTGCTCGCAGACCTCGCGAATGCGCAGCGAGAGCTCCCGTGCGCTCTCGTGGACGGGAAGTGCGGAGGAATGCTCGCCGTAGAAGAGACGCGCGCCGTTGCGCTCGAGCTCAGCGGGGATGCGGCCCCAGTAGTTCACGAGCTTAAAGTCGCGGAAGAACACGCCATGCACGAGCAGGATGGGGTATCTCGTGGCGCACACGCGTTGCTGGCGGCGGCCCTCATTGAGACGCTCCCTCTCGTACTCGAAGCGTGCCTCCGCGTCGAGCGTCGAGATGATCTTCAGGAGGAAGTGCAGGTGCACGAGGGGCACCATCCCAAATATGCCACCAAGGACGCGCAGGCGCAGGCCGAGCTGAACGCTTCTTGCATAGGCTCGGACCATGCCGCACCAGAACACGAGCGTCTCGGTCGCAAGGGCGACGCCGAGACACATCACCCAGAAGGCGGGTTCCTGGGGCACGTTCGGCACACCGCCGGGCGCAGGCCAGCACAGGGCGAGACAGCCCGCCACGATGAGGAGCGCGGTGGAGGCGAGAAAGACGATGAGCAGCTCGCAGGCATTGCGGCAGGACCTGATGCGGGGTTGTCGCGTCCTCTCCCCATAGGGCGCGGGGCGTATGCAGATGGCCAGCACCCAGCATCCCAAGATGGCGAGGGCAGGTGCGGGCGCGATCGTCGGTACGCAAACGCAGGCCACCAGCGCGCACACGACGAGTGCGTTGACAACGCGGAATATCCAAGCAACGGTCCTGTTCATGTTCCCTATTATACGACCCTTCGCGCTTTCTGGCTGACGGTACGGGCTCGCAAGATCATGCCGTCAGCCGCATCCTGCACCATTCGTGTTAGACTTCCCGCAGCGGGTTTCGGCGTACGCTCGGCGCGGTGGCCTGCCGGTTGAAGATGGGTTCCGAGAGCCTCTCAAAGATAGCCTTCTCTATCTTGTTCTTCATCGTTCTCATGTTGTCGTAGCGTGAGGCGTGCGCGACGAACCACGAGAGTATGCCGCTGTTCTCGATGAGCGAGCGGTCCTCGCCGTCGAGCCTGTCGACCACCCTCTGGTAGTGACGCGTTGCGATAGTTGCCTTGTTCTCGTCTGACAGATTGGAGAAGGCGACGCAGGCGCTGATGCGCGAGAACATGGCGGAGCCCATCGCACGACGGGCGTCGCGCTCGGACTTGAAGTTGGTGGTGAGCAGGAACAGGCCGCCCCTCATGTCGACGTCGTAGTTGGTGTCTATGTACCTGCCCTCGTCGAACAGCTGATAGAACATGTTGTAGAGGGTTGGGCCGACCTTGTCGAACTCGTCGATGAGCACGACGTTCGACTCCCGGCCGAGCAGGTCACGCGCGAGGCTCGCCTTGGAGTGCTCGGCACCGAAGAGGTACTCGTACGCCTCTTGCGTCTGCATCATGGAGAACTGGATCCTCATGAGCTTTCCGCCGAGCGCCTTGCTAAGACAGCGGGCCGTCTCGGTCTTGCCGACGCCGGAGGGTCCGTACAGCAGGACGACGGATGGTCTTCCGTTGCCCATGACGGACAGCCTGTACAGAGACGCCACGAGGACCCGCTTGCTCTCCTCCTGTCCGAGCACCTCTTCGCAGACATTGTCGTAGATGGCCTCGAGGGCGCCTTTCTCGACCTGCTCGTATCGGTATGAGATCTGCTCGACGCTGTCCTTGCCTTGGGCCGAGACAAGGGACTCCAAGGCCCTCCTCGGCGGGTTCTGGACGAAGAGCGTCCCAACCTCGTATGTCTCCTCGAGTATAGTGGCAAAGTTTGCGATGACGTGGCTCAGGACGGAGCCGAAGTCATCGGCGTGGACGACGCAGTTGTCCACGTAGTCTGGGACACTGATCCTCGGTTCATGGGAGGCCAGGTCACTCGCCCTGATCTTGGCGTTGTAGCTCCTGATGGCGTCGAGATATCCGACCGTGCGGTCTCCCTCCCTGACGCGCGAGCCTACCAGCTCGTCGAAGCCCGTCCGTGGCCCAAAGTAGATGATTGCCCTATCTGCCATGTGCCTCTACCTCCGCGAGCTTGATCCCGGGCATGTCCATCAGCCCTCTTTCCGCCCTGTTCCGCCATGAGGGTGGGGGGAGATGCGTTCAGGCGGACCTTGGCCCGTTTCCCGCCGGACCTCTATCGCCCCTTCGCCGGACCTGTTGTCGGTGCAGACGCCTTCGACGCTATCGGCATCCGAGTCGCGTCTCTCCATTCTTGCCATTGCCTGCATTGTAGCGTGTTGCTAGCTGAGAGGTCCGTCACGCACGTCCCCTGAGGGGGCGGTGCAGGCAGTTCCCCTCTCGAAGTGTCCTCTCGAAGTGTAACGTGCGCACCCTCCGCCGACCCCGCCCGCGCGAAGTGAGTGAATCACTCACTTCATATACCTGAAGTGAGCGGATTACACACTTCGATATTTTATTCAGTAAGTCTTCTACCTGCGTATATGTAAATTCGACTGTATGAGCGTACGCAGGTTTTGGCCCAAAAATCACTCACTTCGCGATGACGATGTGAGTGAATCACTCACATCACGATCCGTGTGAGGGGCGAGACGGGCGCCGGGGCAAGACGGGCGCCGGGGCGAGATGAGCGCTGGCTTCCGCCCGGTCTTCAGCTCCCACCTAGGCTACGGCTCCGAGGGTCGTTGCGCGCGCGGGAATGGGTCACTTTGAGGGTGGAAGAGGGGCCCGTATCCCGTATCATAGGTATCTATGTTTCTCCGCGTCGTCGGTAGGCGCCTTCTTGCTGGCCCACCAAGAAAGGACAGTCATGCAATACAACATCATCGGAGGGTCATTTCCCGTCGTGACCTGTAGTCTCGCTGACGGAGAGTCCATGGTCACCGAGAAGGGATCCATGGTGTGGATGACCCCGAACATGCAGATGGCGACCTCGGGCGGCGGCCTGGGCAAGATGTTCTCCAAGGCGTTTTCCGGGGAGAGCATGTTCCAGAACATCTACACCGCCCGAGGGGCCGGCATGATCGCGTTCGGCTCGAGCTTCCCGGGCAAGATCGTCGCGGTCCAGATTCAACCTGGCCATAGCTGGGTCCTGCAGAAGAGCGCCTTCCTCGCCTCGGAGATGGGTGTCGAGCTGAGCATCTTCTTCAACAAGAAACTGGGTGCCGGCTTCTTTGGGGGCGAGGGCTTCATCATGCAGAGGCTGAGCGGCAGCGGCGTCGCCTTCGCCGAGATAGACGGTGACCTCGTGGAGTACGTGCTCGAGGCAGGTCAGCAGATGATAGTCGATACGGGCTACGTGGCAGGCTTCGAGGAGAGCGTCTCCATCGATATCCAGTCGGTCCGGGGCGTGAAGAACGTGGTCTTCGGCGGTGAGGGACTTTTCAACACCGTGCTCTCGGGTCCTGGGCGCATCTGGCTGCAGACCATGCCCATCTCCGGCGTCGCGGGCGCCATCATCCCGTACCTGCCTGCGAAGAGTTAGGGAAGCGCTGATGCGCGGCTCTTCGGGGAGCCATTGGATGGTAGGGGTTGGTCTACAGTGTTGGCTACCTCGAGACACACGAGATTAGACCTTCCTCTGCCCCAATTGAAATGTGCTAGCTGGGCTATCGGTGAGCCTAGGCTTGGCACTGATAGGAGGTGCATTGTGTCTGTGGGCACAATGGCATCCCTGTTTGTCGGGATAGCAGTTTCCCTGTTAGTAGGCTTGATGGGTGTGTATATATTGGTGACGGGAAACCCGAGTCTGTTACATGGCCATCACCGCGCAAAGACGAGACCTGACGATCTTTTGAGGCTGGCACATTGGTGTGGACTTGGCATGACAGCTGCTGGAGTGGGGTTTGCCCTGCTTACGGTGGGCACGGCGGCCGTCTATGGAGACTCGCTTCCGGCATGGGCGGGGAATGCTGTCATCCTGGCCCCTGCTATCACACTTTGCACGACGGGAATGATAACAATATTTGCCTCAATTATTCACTATAACGGGTCACTCTTTTCATAGGGTACGTCAATGTTGTCGGCAGAGGGGTTCTAGAAGCAAGTATGCGGCGGCACGTCCAGGTAAGTTATCGCATATAAGGGCAGGATATTATGTTCAGAGACGCGCTCAGAAGGATGTTCGCCTGCAGGGACTGGGACTGCGAAAACCAGCCAATCCCAGTCAGTCAGAACTAGTCAGTCAGAATAAACCGCCGTCGACCCCGACGGTACCGAGGGCAGACGATCTCGGACCTCCTGCCGTGGCCGGGGCAATGCTCGACGGCCTTGCGCCTCTGCTCCTCCACGAACCTCGGCTCCCGGTTCGTCTTTGCAACGGAACCCTCGCCGGTAGCCTCATACTCCTCCCGCCAGTTGCCTGGCGTATGCCCACCGGGGTAGCCAGGCTCGCCCATCGTGTCCGAGTAGCCATAATCGAGCCTGACGAGGGTCTCCATGGCGTTCCTTCCCCGCTCGGCGCCGTGCATACGACTTCCTTCCTGGCCCCGTCCCGGTCCAAGATTCCCACTGCAGTCCCGTATATGGTTGTTTTTGCCCGACGTTAACGCACCTTTACGCTTCTTCCTCAAAGTCAGACTTGGCAGCGCCGCAGAGGGGACACACCCAGTCATCAGGGAGCGCCTCAAAGGGCGTGCCTGCCGCGATGCCGCTGTCGGGGTCGCCCACTGCAGGGTCATACACATAGCCGCAGGGGCCGCACACATACTTTTTCATACCTCAATACCTCGTCGTTTTTCTAATTTTGTTGTTTTCTATGACAGCAAAGCCTTTGCTAGGGCGGGCACGGTGGCGAAGTCCGCCTCCTCCGGATTCCATTGGGAGCGCACATGCTCTTCAATGACGGTGAAGCCTGCCTCCCGCAGCTTCTCCTGCAGCAGCTTTACGCTCTCGCCGCTCCAGCCGTAGCAGCCAAAGGCTGCGGCCTTTTTATTCTTGAACTTGAGCTGCTTCAAAAACTCCAACCAGCCCGCCACGGAGGACAAATAGCTGTTGGAGACCGTGGGACTGCCCACGGCGATGGCACGGGACTTAAAAACCTCGGTCATGAGCTCGTTTTTATCCGTTTTGGCGAGGCTGAAGACCTTTACCACTGTCTCCGGGTTCTGTTTGTGGAGCTCTGCGGCGATGGCGTGGGCGAGCTTTGCTGTGCCCTCCCACATGGTGTCATAGACGACAGTGATCTGATCCTCCTGATAGGCCGCTGCCCACTCCTCGTACTTGTTCACGATCTGCAGCGGTTCCTCCCGCCAAATGGCTCCGTGAGAGGGGGCGATCATCTCGATGGGTAGACTGAGCTTACCGATCTCTTCCAGTTTCTTGACGAGGATGGGGGAGAAGGGATTGAGGATGTTGGTGAAATACTTCATAGCTTCTCTGTAAAGGAGGCATTGATCCGCCTTGTCGTTAAATAGCTCTTCCACCGCATAGTGCTGACCGAAGGCATCGTTGGAGAAGAGGATGTTGTCGCCGGTAAGGTACGTCGCCATGGAGTCTGGCCAGTGGAGCATTCGCATCTCCACGAAGACAAGACGCTTCCCGTTGCCGATATCTACGCTGTCGCCGGTTTTTACCACGTTGAAGTTCCAGCCCCGCTTGCCGTACTGTCCCTCGATGCTCTTGACGGCATTGGCAGTGCAGTAGATGGGCGTGTCGGGAATTTTCTCCATCAGCGCGACGAGAGCTCCGGAGTGGTCACACTCACCGTGGTTGGCCACGATAAGGTCGATCTTATGGAGATCGATCTCCTTTTCCAGATTCTCCACGAACTCAAAGCGGTGGGGTAGCCAGACCGTGTCGATGAGGGCGGTCTTTTCCTCCTCGATGAGATAGGCGTTTTGGCTTGAGCCGTTTTTGATGGAGTAATCCTCACCGTGGAACCACTCCAGCTCCCAATCGATATAACCCACCCAACTGACGTTAGCTTTTACATGCTTTCTCATGGTGTCCCCTTAGTTCAGTGTTGGCAGCAGGGCAATTTTGAAGCGGTCGTCCATGTTCACGATCTTGCCTTTCTGGTAGGGCAGCAGATCTTTCAGGGCGAATGCCTCGTCGCCTTATAGTTGGCTCCTCATGTGCAAGATCCCCTTTGTCCTCTCCACCTTTGCCAGTATAGAGATACTCTGCAAGAAGATCTGTATCTCAGGATACAAGGAAGTGATTTTTCGCTGTATACTTAGCGGTCACTACTGAAGGGGGGTGCGTTCCATGGACTTTCACATCCTAGAAAGCAGCTGGCTGTTTCAGGGCTTGTCAGCAGAGCGGATCAAAGAGCTGTTCCAAGGGATCCCCTCTATTATCCAACGTTATGAGAAAGATGAGACCATCTTCCAGCCCCTTGAAACGGCGGATCGAGTGGGCGTAGTTCTGAAAGGGAGCGTACAGTCCTATAAGTTGTTTCCCAATGGCAGCCAGGTCAATGTCACGGTCCGCCAAGCCGGCGATATCATCGGTTCCGCTGCAGCACTCTCGGTTCAAAAAAAGTATCCCTCTGGTGTAGTGGCCTTGGAGCATACGGAGATCCTGATGCTTTCGCGCGACGATTTTCTTCGTCTGCTGAAGCGGGATCCGCATCTGGTGGAAAACGCCCTCTTTGAGATCTCTACCATCACCTACATGTTGCAGCAGCGGTTGGAGCTGCTGTCCTATCATGGGATCGATCAGAAGATCGCATTCTGTCTGCTGACGCAGTCTGCGCAGAGCGGTGAAGCTGTCATTCCGATCCCCGGCTCCATGACCAAATGGGCGCTGATGATGAACGTCTCCCGTCCCTCGCTGCATCGGGAGCTGAAGCGGCTGGAAGAACAGGGACTGCTTTGCCATACGCCGGCACTGATCAAGATTCTGGATCCGCCGGCGCTGGGGAAGCTCTTGAGAAGATGAGCTCCAAGCGAAAACCGCCTGGAGTTTCCCTCAGACGACCTGTATGGTGTAATGGCCTTTTCCCTTCGTGGTACGGTGTAGCCCCTGCGTGGACAACATGCCGTCCATCACATTTTTGGCGTAGCGGGCGAAAAACTCCCGGATGTTGGAAAACAGCTCGCCATGCTCCTCCGAGGCACCCAGCTTTGTCTGCGCTTCTGTGAGCCGGTTGGCCAGGTCTTCGCTTTCCTGCGTCAGGATATGCAGCGGATCGGTGGATGGTCGGGGATGGCCGCAAGCGTCGCTGCACACCTGTGGTTGATGCAGGCCGACGTTAACAGTGTCGCCAAGGCGCCAGAAATTCTCGAAAAAGTAGTTGACAACTACTACGGGTACCGATATATTATTCCTAACGATATAACGCAAGACGATATAGCGGAAGACGTAAGGAAGGAGACATAGATGCCAAAGAGGGAAGACAGCGGGGCACTGACAGAGCCGACGTTTTATATTCTGCTGTCCCTACACAAGCCCACGCATGGATACGCGATCATGCAGGACGTGCGGGAGCTGACTGGCGGAAGGGTGAGCATCGGGGCGGGGACGCTCTACGGTGCCATAAACTCGCTCACCGAGAAGGGTTGGATACGAGCCGCAGGGGACCGTGCGTCTGACCGCAGGAAGGAGTACGTGATTACCGAGGGTGGGAGACAGGCCTTTGCACGCGAGGTCGAGCGCCTAGAGAGCCTCGTCGCCGACGCGAAGCCTGTCATCGAGCGCTCATTGCACGCATAGAGCATCAACTAAAAGTATCACATAGACTAAATTCACAAAGGGAGACTGACATGAGCACGAGCACAACCATCAAGAGGGCATTCACCGACTTCTCGAAGGAGGAGGCCTGGCTTAACGAGATGAGCCATGAGGGTAAGGCTCTCGTCGACTACCGGGGCGGTAGGTACACCTTCGTCGACGATGAGCCGGGCACGTGGCAGTATGCGATCGAGATCCTTGGTCAGGGTGGCAAGGCCGGCAAGGAGTATCTCTCCTTCCTCGAGGAGACAGGCATCGAGACGGTAGCCGTCTACGCGAACCGCGCCTACCTGCGCAAGAGGGATGATGGGACTGACTTCGAGCTCCATAGCGACCTCGAGTCCCGCCTCGAGCAGGCCAGGAGGGGGAGTGTGCCTTGGATAGCCATCCCGGTGTCGCAAGTCGGCCTCGCGTTCATCCTTGTCCTCAACGCCTTCGTGGTGGACTCGGAGGCATCGAACCTCGCCAGGGGCATCGTCCTCGCGTGCGCCACCCTGCTTGCCTTCGCAGCCATAATCGAGTACCTCGTCTTCGGCAAGCCGTATCGCGAGCGCGTCCGCCAGCTCGAGCGGGAGCGCTCGATCAGGGAGTAGCGGGCGTGGCCTCAAAAAGCCATCTTGATCACTGGGCGGATCCTGCGACAGGCGGGGTCCGCCCTCACCCCTTAAGATGGGTGCTCAACGATGCTGACCCTCACCCATATGTAAAATTATATTTAATAGTATTGCATTATATTAAAATCAGAGTTATACTCCAACTAAAGAAAAGGAAGGAGGTGGTGATGATGGATATCGCCCATACGTGGACTGAACGCTTGGGCGACGAGGATCTGGAGTTCGCGCGGCAGTTCATTATGGCCTCGGGCTCTCTGAAGGAGATGGCGTCAAGGTACGGCGTCTCGTACCCCACAATCAGGCTGCGCCTTGACAGGCTGATCCAGAAGATCGAGAGTGTGCGGGAAGACGATGACGCCTTCGTGTCGCTCGTAAAGGGCATGGCCATCGACGACCGCATGGACTTCGAGACCGCACGGCAGATCATAGACGCCCACAGGCAGCTGATGGGCGAAAAGGAGGGATAGGAATGAGTGTGGACGGCGATGTCGCCAGGATGTCCATCGTGTGTATCGGTTTGGCGCTTGGTACGCTCGAGTGGTTCATCGTCAGGAGGACGAGCTTCAACAAGTGGGTCGTGCCGGCGGTGTACTGGGTGGGAGCGCTGATATGGTCATCTGCGACTGGACCTACGCCGGTGCTCTTCCCGAGCCTGGCGATAGGTCTCTCCATGGCGGGCTGTGCCATCGAGGACGAGATAATCAACGGATACCTACAACGGAAAGGTACCTCCGGCGTCGATAAGGCGAGGCTTCGGGACCTGTAGCGAGGATGTGGCTACGCTCGGAAGTGGGGGTCAGTGCCATCGCGCTGGCCCCCATCCTTTTGGACTTGCCACCGCCCTTCTTGCGGTATGCCGCCCGCGACAGGCACCAAGTACGATGGCGCTCCGCAAGCGTGGTCGGGCCTCCGTCGGGCGTCCCTGCGCTCCATGAGGCTGTTAGGGGGTATCATTTCCCACGTTGGGTTTATCGGCCCCACGCCGATCCCACGGAATGACATCGACCCTATGGAAGGGGGAGCGTGCATGAGTTTCAAGAAGATTGCAGTTGCAGGTGGTGGTGTGCTCGGTAGCCAGATTGCCTTTCAGTCAGCGTACTGCGGCCTCGATGTTACCATCTGGCTCCGTATGGAGTCCTCCATCGGTCGCTCGCGGCCCAAGATAGACCGTCTGCGCCAGATCTATCTCGATACCCTCGAGGCCCTGAAGACGGACCCGGCCGCCTACGCATACGGCCTGATCGCGCGCGAGGACATCTCGCCTGAGGCCCTCGACGCCTGCAAGGAGCGCGTCGAGCAGGCGTATGCGTCCCTCAGACTCACGACCAATTGGGACGAGGCGTTCTCTGACGCTGATCTTGTGATCGAGGCCGTGGCCGAGACCCCGGACGCAAAGACAGCATTCTATAAGGAACTTGCCAGGCACATCCCAGAGCGGACCGTGATTGTCACCAACAGCTCGACTCTGTTGCCCAGCAGCTTCGCCGAGACAACCGGTCGGCCTGACAAGTTCCTCGCGCTGCACTTTGCGAACGAGATCTGGCGCAACCCCACGGGCGAGGTCATGGGCCATGCTGGTACGGATCCCACACACTTCGAGGAGATCGTTGAGTTCGCCTCCCAGATTCGCATGGTTCCCATCCGCGTCCTCAAGGAGCAGCCAGGCTACATCCTCAACTCGCTGCTCGTGCCCCTGATCGCTGCGGCCCTGAGGCTCTGGGCCACTGGTGTCGGCACGCCTGAGGACATCGACAAGGACTGGACCATCTCGACCGGCGCCCCATACGGGCCGTTTCGCCTGCTCGACATCATCGGCCTCGTGACGCCGCTCAACATCATCTCGAGGAGTCCCCAGGCAAAGGACGAGTCGTCTGTTGAACATAAGATCGTACAGATGCTCCAAGCCAAGATGGACAGGGGGGAGACCGGCGTCAACGCCGGCAAGGGTTTCTATGACTACGGTGGGGGTGAGCCAGCGGCAAAGTAGGTTCCTCCTTCCGTGTGTCGAGGAAAGCCACTCTTGCGAGGCTCGTCTATAGGGTTGTGCGGTAGGCCTATGTGGGCTGGTGCTGCGATGGGGTTTGTCGCCACTGGACCCTTCATAATTTATTGCTGGTGCCGAGCGGACCTTTCCCTCGCGCATGAGAGGCATCGAGATCGTGTCGTACGACGCGCGGATCGCCGGGACCTTCCCCTCGTGCATGGGAGGGCTGACTTTTGGGGGTCTCTCTGTGGCAGGGGACGGTCCGGATCACGCCCACGTCGCTCGACACCCTCTTCATATGGAGTCACTGTGGCGGCGTGTATCTTGATGATGCAGGTAAATGTGAGGCCCGCCGTTGTGCGGACGTGTTCGTGCAAGCCGATATGCCGAGGAACGGGGGAGGGTATACCATAAGAGGGTCGACGAGGCGTTCCGTAGGGATGCCTCGTTTAGGGCGTACGCCGCGTCTTGGCAGGGGGGTCTGATCGCGATGACAGAGGTGGGAGCAGGGGTGTACGCGGGACTGCGCTGTGCGGACTGCGCGTTTTCCGAGTTCGTGCTCAATGAGGAGTCTGGTATGTTCGTGGGAACCTGCTCGCGTGGGTATACGCTGGCAGACCCTCACGTGCACGTGTCGCCGGACAGGTTCTTTGCAAAAAATCCCAGGGCGCTGGTCCCGGTGACGGACCCCTACGGCAGGGAGTACCTGCGGACGAGAAATATCTGTACGAGGTTCGCACCCAGAGAGGGCTAGCGGCGGCAGGCTCTGCCTGCGTCTGTAGCCTGCGTGTCGGGTGGCATTCGCTTCCGGATGGCGGGAGCGTGGGCCCGCACTTTAACGTGGAGGACGATGGCGTCTGGAGGAGGGTGCGCTTTGGGTACGGGTGACGGGGTCGCGCCTCCCGAGGGCTGGGGCCTCGAGGTGTGGCGTCATGGGGACGCCTGCGGCGAGGGGGACTGGGGCCCGGGCGAAGACGGCCCGCCGCTGGCGGGCATCGGCCCCGGCCACCTGCGCCTCACCTTCTACTACGGCGGCCGGGTCCACGAGGGGACGCGCGGCAGCCTGTACGAGTGGATCTCGGCGTCCCTGCGCGCCGCAGGGGCGGCTGCGGCGGGTCTCTGGCGCTACGAGCTGCGCTACGGGAGTGGCACGCGGATCGACGCCTTCGGGCTCTGGGGGACCATGTGGAAGAGCATGGGTCCCGGCCGCGCTGCCGCCCTCGCCCGGGCCTCCTCCCTCGGTTGGGAGGGAGGGGAGGAGGCGTCCGTCCGCGTCAAGGGCAGGGAGCTGCGCTGCGGCATCTCCCGGGAGAGGTTCGCGGCGCTCTCGGGGAGGGGCGTCGAGTACCTTGGTCCCGTTGGCATGGACTGGTCCGGCGAGCTCGCCGCCGACCTGCTCTTCGCCCTGTCGGACACGTGGTCCCCGCAGTTGTGGCGCTACGTGCGGGGCAGGGACCGGCTCTGCGGCCAGGTGTGCGAGAGGGGCGGGATCGCCGTGGGGCGCTCCGGTGACGACACGGGGCTTGCGGCCTACCTCACCGTTTGGGAGGAGGGCCCCATGCACGGCCTGCTGCTTCGCGCCGCAGAGGTCGCCCCCCGGCTCAGGCCCGGCTCACCTCGTGAGAGATGGAACGAGATGTTCCCTTAGCAGGCGCCTGCATTACCTGAGCACCCGATTTGCGATCCGCTCGCCATGCGAAAAGACCTGCCATGGCTGAGAATAGGGATGCAGTCTGAGTCGAGCGATATCCATGTCAGCATAGCCATGGCCTACCATAGTTTGCAGATGGGGTACGCTATACATGGCAATTATGGTAATTGATACTTTGCAAATAGGGTAATGCTTCCACCACACGCTGGGGATGCGAATCATCCTGTTGGGGGTCGGTATGATCAAACGTGGCGTTGCAGGATTCGTCCTTGACAACGCTTCGTGGTTTCCCGTGGTCTCGGTCACGGGGCCTCGATAGAGCGGGAAGTCAACGCTCGTCAGGAGCCTCTTTTCCGACTACGCATACGTGAATCTCGAGGACCGCCCCACTTACGAACGCGTGATGGCAGGTCCGTCCGACTTCATTCACGAGTGACCCCCTAGGATGATCATCGACGAGGCGCAACGCGTGCCAGAGCTCTTTAATGCCATACAGGTGGTTTCCGACGAGCGTGGCACGGTAGGCCAGTACATCCTCTTGGGATCTCAGAACTACCTCCTGCTGAGGCGTATCACTCAATCCCTTGCGGGGCGCATCGGGCTGGTACGGCTCATGCCACTCTCGTATCGCGAGGTAGCTCTGGCACCAAACGAGGTGACGCCAGATGGGTTCATGCTGCGTGGAGGGTATCCGCGCCTCTACGACGTTGATATTCCTAGTTACGTTTATTTCGAGAACTATATCTCAACCTATGTTGAACGAGATGTGTCGGAGTACGTCGATGCGCGTAGCAAGGGGCCTTTTCGCAGGCTCCTGATGCTGTGCGCACAGTCATGCGGATCGCTTCTAAACGTATCGCGCATCGCGAGCGACCTGGGTGTCGCGCGAGCGACTGTCGACTCATGGCTTTCGATACTCGAGGCAAGCTACACCATCTTCAGGCTACAGCCGTATCATGCCAACCTCAGGAAGCGTCTTACAAGAACGCCCAAGATCTACTTTTGTGACACTGGCCTCCTATGTCACCTGTTGGGCGTCGAGACCTCCGAGCAGCTGCGAGACAGCGAGATGCGCGGCGCCATCTTCGAGAACCTCATAGTCACAGAGACGGCAAAGCGGCATCTCAACGCGGGACGGACTCCTCGGCTCTTCTTCTACAGGGATGACTCGAAGATTGAGGCTGACCTGGTCGATGACAGCGATCTCGCAGGTAGGGAGCTTATAGAGATTAAGTCGCAGGTCGGGTTTCGCAAGGACTTCCTGCGACATCTACCGGTGGTTGGCAGGGACCTGGGCATAGCCGAAAGGCGGCGGTACGTTGTCACGCGGGGGGCAGACTCGTTTTCCGTCGGTGGCATGAAGGTGTGGGCGGCTCGCGATTGGCTCATGAGACCGTAGTTCGTGACGCCGGAGTCAAGCGGAAGGCCTCCTGGCAGGTGTGAGCTTACCAGGCTACAGGGTGCCGGTTGCAGGGGCTTTTCGATACGGATTGGCATGCGCCACCAAAGGCCGCATCCATTGAGATGGTGCTTTCGTGACCCCTATTGGGCGTCATGGCCTCGCGCTATGTGCCTCCGGAGGGACGCGTGGGACACGGGCGCCGGGCCTGCGGGGCTCGACCGCGCACTCGGCGACACCGAGTGCGCGATGCGCGTGCCACCCGGCGCCACCGAGTGGCACAGCATTTCACGACAACTGTACATATGCCGACTTCCGCGCCACTCGGCGCCACCGAGTGCGCAGTCTGCCTGCCACTCGCCGCCGTCGAGTGGCGCCCGTGAGTCAGCGCGGCTCGAGGGTCATCAAAGAGATGGGCGGCACCGGATGGTACGCGGCTCGGGACCATCGGGAGGGAGGCGGCACCGGACGGCAGTGTGGCGGCCGCAGGTCCCTCACGCACCGCGATTCCCGACGCGATCCGTCGTTGCGCGGGACTGTGCCGGGCAGGGCCGCCCACAAGGCTGCGTCCGCCGTCGACGTCCAAGGGCGTTCGGCCCACCCGTGAAAGGCGGCCACCGAGCGCGAGGGTGTGTATGGGGCCGCGATGAGGTAGGATTGCGGTGGGGTGGGAGACGCGAGACCCCATCGATTGTGTTGCGAAGAAGAGCTGCGTCGTGTCACGGGCCGGAGCCAGGGCCCAGTGGCGTAGGTGTTTGGAAAGGGGCTGCGATGTTGTCCTGGTTGAGGGACCTCTTTGGTATAAAGCGCGCCGAGCTTCCCGGTGATGATCCCGTGCGGTCCCGCGTACCCCTCGCCGAGAGTCGCATCCTCGTCGTGCCCTCTGGCTATAACGTGCGCGAGCTGGGTGGCTACCCCACGCCGTATGGCCAGACGCTCTATCATCGCTTCCTGCGCTCCGGTGACACCGATGAGCTCAACGGTGCTGACATAGCCGCCCTGCGTGACTACGGCGTCTCGATGGACGTCGACCTTCGCAGCCAGTGGGAAGTCACCCATTCCCCCGATCGTCTGGCCAAAGACCGGGGTGTCCGCAGCCTGCATGCGCAGCTGCACTCCTATGACATGCATGCACACGACCTCAAGTTGCCTGATGACACCGAGGGCTACATGGCCAACGGTTACCTCTCCATGCTTGAGAACCGCAAGGTCGTGCGCAAGATCTTCTCGTTTATGGCCAAGGCTGCCGATGACGAGTGCGTCCTCTTTCACTGCGCGGCTGGCATGGACCGCACAGGTGTTACGTCCATGCTGGTGCTGGGGCTCTGTGAGGCGAGCAGGGAGGATATCCTGCGCGACTACCTCTATTCCTTCGCCGATGCCGACAGGGTAGAGGAGCTGCTCGAGGGGAAGGATTCCGCCCGCAGTGACTTTGATGGCCCCATGGGGGCCGATATGCTCATGCACACCATGTCCGCCGTGTATCAGGCGCTGCTCGATGGCTGTGGCTCAGTGAGGGGCTACCTGCTCTCCTGCGGCCTTGGCGAGGATGAGCTCGACCGTGTGCGCCACCACCTGGTGGGTTAGGTCGCAGGTCTGTGGGCCCTCACTCTCACAGTTGGCACAGGAGCGCCTCTCACTAAACGCCCGATGTCTGCAAGGCGCCAAGAGCGTACAGCGTACTGAGAAGCCTACTTGGGGGAGGTGAGTGTTGCCCACGTCGCGCCAGTGGCATAAGTGCCTTGGCGGGCATTTCGAGCGTCATCGAGACTACCGCTCAGGGGCAAAAACATGCCGTTGGCCCCGCCGATTGACCGTGTACGGAAAAGCTGGCCCCGTGTACCTGTACACCCCTTTGGAGACAGCTTCAGCTCGACTACCCTCATAGTGTGGAGAAGAAGCATGAGGGCAGTGCGACACAGCGGTCCGTCGCGAGGAGGCGCTTGCGCATATGGGTTGGAGGTCTAGGTATGTGGTGCAGGGCATGCGGCGAGGGGGCAGCCATGAGTGACCTCGTCTTCATCGTGCCGGCACTGGGCATACCCGCTCTCGTCTCGGCGCTAGAGTGGACGCTCCTGAATGACATCGTCGAGCGCCACCATAGCCATCATGATACCTATCGTGTCTCCAATACGCTGACGCACACCCTCGTTATGGTCATGGTGTTCATGGGTTTCCTTGGCGTGGTTCTCGGATGGCTCTGCAACGTCGGCGTGTTCAGGGCGAACAGCCACGTCCTCCTCGCGTTCTTCCTGTCCTTCTTGGGCGTGTCTCTCCTGATCTGGACCTGGTTGCATCGCTACAAGGTCGTGACCTACGACGATTGCATGCACATCACACCGCCGATCGGGACAAGGAGGACGATCAGATACGACGAGATCGAGAGCATGGAGTGGCACCGCTCAAAGTCGCTTCTGGGCTACGAGAACCTGCGTGTGCGTGTCAAGGGGAGCTATTGGTGCGTGACCCTCTGGGGCATGCTTGACCTCGAGCAGATCCTCATGCGCATCAACCGTTACGATGCCATCGACAGCGAAGGCGTGTACTGATCCTTAGAGAGACGCCAGGTCGGTCGGACGCGCCTATCGGCCAGGCGACGCCGGCTTAGATAGGGCCCCGCAGATTGGCGGGCCCTATCAAAAATCCGCCAACTGGGCAAACGTCCCCGAGATAGTACCCCGCAGATTGGCGGGTACTATCGAGCGCCCGCAGGGGCCGCCGGCCGCTATCGGGTCGGCTTGATAAGGGGGTACACGAAAGACGAGCGAGCACGAAACGAGCTTCTGATGGTGAGCTTGTCGCTTATGGGGAACCAGCGCGTGGAGAAGACCTCGGCGCCACCATTGGCGTAGACCTCGATGGTCGAGCCGTCCACGATCATGCGCAGATCGTCGAGAGACGCAAGCCTGATGCCGCGAGTCCGTCGACCAGCCGAGGCCAGCTCTCCTGCCTCGGTCTGAGCAAAGCGAATGCCGAAGCTGCCGTTCTCGGCGAAGACCTCCAAGACGTCATTGAGCCAGATCTGCGCATCGCCGTCCTCAATCTGCTCGAGGACGACGTCTGCCGCGAGGCTGTCAAGCACGAGGCTCTCGCCGCAGGGCAGCACGCGAGCCTCTCCACGGTAGTTGTCAAGCTCAGCAACCGGATGCTGGCGCAAGAGCCCGTCCTGACCAAGAGAGATCTCGCGCGGGAGCGTCATTGTATGCGCCCGGTCCATGCCTTCGGGCACGCTTGTGTAACTGTGGTCGAAGGTGCCCATCCAGCCAATAGAGATCGTGCGACCCCCCTCGTCCGTGAAGATCTGGGGTGCGTAGAAGTCAAAGCCATGATCCCACTCGGTGAAGTTGTCGAGCGGGACGGCGTCGATGTCGATGATCTTCTTGTGCGCGGGAAGCGGGAAGTACCCCGCCTGCCAGAGATTCTGCCAACGATAGCTCTCGGAGGGAAGCCCCTGGGGGCAGACTGCCAGAAACTCCCTGTCTCCCATGCGTATGACGTTGGGACACTCCCACATGTAGCCAAAGACCAGGTGTGCCACCGCCGTGTTCTTGGGCAGAATGGTGCGGCGCAGCTGCCAGCTTTCCCCCTTGTCGTGGGAGTCGTAGACGAGCACACTGCCAAAGTCGCCTCGAGCATCGGGATTGTCTGTGTCGGCGGGCCCCCGCTGGCGGGCGCCCAGCAGCATGTGCAGGCAGCCGTCCTGTTCCCAAACCGTCGGGTCGCGCACATGCAGGGTACAGCTTGTGGGGTAATCCGCATTAGTGAGAAGTGCCTTCTTGGGCGAGAAGTGCAGGCCGTTCTCGCTCGTGGTCATGATCTGGTTGGCCTCTCGCCCCCAGTCCACGCGCTCGTCGTCGAAGGTGTCGACGACGTTGCCTGTGTAGAACACGCGCATGAGGTCACCGCCGTCAGGCGCACCGCCCTTGTCCACCCAGGTACAGCCCGAGAAGACGCCGCTGCGGTCGAGCTGGATGTCGGGCGCGAGTGCCACCCCCAGATCCTCCCAGCTGATGAGGTCGTCGCTCACCACATGACCCCAGTACTTGAGCTCGTCCGTCGGCCAGTTGGGCGCGTATTGGTAGTACGCGTGGTAGCGTCCGCGAAACTGGCAGAGGCCGTTGGGGTCGTTGAGCCAGCCCTGTCTTGGCTCGATGTGAAACGACGGGTTCCAGAATTGCTTGGACATCGTTCTCCTCAGAAACGCACTCGATGCTGGGTTTTAGGTAATGGTTCAGAGAAATGCCGTTGAGATTATAGGGCGGGCATGCAGGTCGTAGGACGTGGTTGGAAAAATATGCACCTCACTCATGGGAGACACACGGCGGCATACTTTGTGATCCCGTATGAATGAGAGGTGCCTGCTGGCGAGTCATGACGCGGCCGATGGGACAGTGCAGCCCAAGGCGTGGGCACACCCAGCTTGAACGCCCCGGGATGTACGAACCAGAGCTCCGGGGCGTTCGGTCCAGATAGCCTTGCAACGCCTGCGTGCCATGGTTTTAGCTGTCGATGCCTGCAAAGTGGCAAGAGCCCATCTCCCAGCCCTGGTGTCTGCCCTTGAGACTGGAGCTGACACGCAGCTCGTCCACGCTCTCGGGATACCACCGAGTTGTCATCGTGACCTCGCCGCCGTTCACGTAGATCTCGACGATGGAGGTGTCCACGATGACGCGCAGGTTCCTGATGCGGCCTGCCGTAAGCGCCGAGAGGGGAAGGCGTCTGACGCTTCGGTAGGCGCCGGCGGGGCTCGTGAAGGCCAGCTCGCACAGGTTGCCGATGACGGAAAGCTCGAGGTCGTCGTTCAGGCGCAGCACAGCGTCTCCGGATTCGATCTGCGTGACGCAGATGTCGGCGGTGCCCGCGAAGCGCGCGCCTACGGCTCCCGTGAGGTCGAACACGTCGTAGGAAGATGAGCCGACCGTCCCCGTGAGGCCTGCGACGTCACTGGTGAACTCAACCAGCTCGCCGCGAAGCGCGTCGATCTCGGTTACGGGCCACTGACAGACACGCCCATCCTCGTTGAGTGTGAGCTCGCGCGGCAGGGTGAGCGTGTGGGTCCACTCGCGAGTGGGGTTGTCGTACTGGGTCTCGATGTCGGGCAGGCTCGCCCACCCGACCAAGATGGTGCGCCCCCGCTCGTCCTCGAAGACCTGGGGGGCGTAGAAGTCGAAGCCAAAGTCAAGCTCGACGAACCCCGCCTCGTCGATGCAGGGGTAGGGACCGTCCGCGTCCATGAGGCCAGGGTCCTTCGCCATGAGGTCGATGAGCCTGCCGTCGAGGGCGACGTAGCCCGAGTTGTGTATGTTCTGGAGGCTCGTCGGCCGCTTGCCCACGCCCTGAGGGCACACAAAGAGGAACTCGCGCCTGCCGAGCGTGGCGAGATTGGGGCATTCCCACATGTAGCCAAAGGGCTGCCGTCCGAGGTTGGTCGCGGAGCCCTCGAGTCTCCAGCTGAGGCCGTCGGGGCTTTTGTAGAGAAGGATGCAGCCCCGATCGCCCTGAGCGCGTGCGCCGAGCAGCATGTGCCAGCAGCCGCCCTGCTTCCAGACCTTGGGGTCCCTCACATGGCAGGAGCAGTAGGCGGGGTAGCCCTCATTGCCTAAAACCAGGCGCTTCTCACCAAAGGTGGAGCCGTCGCTCACGACGAGGGTCTCGTTGGCGAGACGACCCGAGTAGTCGTAGTCGTGCTCGCCCGGCAGCAGCTGGTTTCCGGTGTAGTAGCACCACATCCTACCGTCGTGGACGGTGGCCGAGCCCGAGTACGAGCCGTTTTTGTCAAGCTCCCGGTCGGGCATGATGGGCGAACCCAGCCACTTCCAGCTGACGAAGTCTCTCGTGGTCCAATGGCCCCACCCATGGGCGGCGTCGGGCCAGAGCCTGCGGTGCTGGTGGAAGTAGTGGTAGGTGTCATCGAGCTGGCAGAGGCCATTGGGGTCGGTTATGTCGCCGGTCTCGGTCTGGAGGTGGAACCTGAGGCGCCAGTTGTGCTTGGGGCTCCACGTGCGCTTGATTGCCATCTTGCTCCTTTTGCGCGTCGCGGTCGCGAGAGGGCCGCTCTGCCGTGGTCGGTTGACGTCTAGAACAGCTAGGACAGGACCTTCTCGACCTCGTCGAGGGTGGGCATGGCGGGGATGGCACCGCGCCTCCGCACGCAGAGGGATGCCACGGCATTGCCAAAGCGGGCGAAGCTCCTGGCGTCGTCGAGGGTCACGTTCTCGGGCCTGATGTCGGCGTCCACGAAGGCGCAGAGGAAGCCTCCCCAGAAGGAGTCACCCGCCCCGGTCGTGTCGACAGCATCCACCTTGAAGCTGGGCACGGTCGCGCTGCCGTCCTTGGTCGCCACGAGGGCGCCCTCGTCGTCGAGCGTCACGCAGATCACCTGTGCGCCCTGACCAAGGAGGATGCGGGCGGCCTCGGTGGGGTCGGAGCGGCCGGTGAGCAGCTCGGTCTCCTCGCAGCTGATCTTTATGAGGTCCATGTACGTGACGATGGAGCGCATCTGCTCAGAGGCCACCTCGGCGCTCGTCCAGAGGGAGTCGCGGTAGTTGGGGTCATAGGACATGACGGCGCCTGCGGCCTTGGCCACGTCGAGCGCGGCGATGGTGGCGCTGCGTGCCGGCTCGTCGGTGAGCGAGAGTGATCCCACGTGAAAGACGCGGCTGTTCTCGATGACATCGCGCCTGAGCTCCTCGGGGCGCAGCTGCGTGTCTGCGCCGGGCTTGCGGGCGAAGGAGAAGGTCCTCTCGCCCTCCTCGCTGAGCGCGACGAAGGCGAGTGTGGTGAAGCAGTTGGGGTCGAGCACGAGGCCGTCGCAGTTGACGTCGTTGGCGACGAGAGTGGCGTTCAGGAACTCGCCGTGCATGTCGCGCCCCACCTTACCGATGAAGGCGGTGGACTTGCCGAGGCGCTCGAGGGCCACGAGGACGTTTGCGGGCGCGCCGCCGGGGTTGCGCTCGAAGAGCTTCTGGCCCGCAGCTGAGGTACCCGCGTCGGTGAAGTCGATGAGAAGCTCGCCGAGGGCTGTGACAGAGAACATGGTGCTCCTTTCCGCAGCGCCGACGCCTGCATCGGCGCTGCCGTATCAGAGAAATGCGGGAGCGATCGCAACTGCGACCGCCCCCGCAGGTGTGCTGACCAAGGTTGCCGGTCAGGGGGACGGACCTACTTCTTGATGTCGATGAGGGTATCGCCAACCTTGACGGTGCCGGTGTGACCCTCGACGGAGGAGAAGTCATCGGTGTTGGTGATGATGACCATGGTCGTTGCCGGGAGGTTGGCCTCCTTGATGGCGCCCAGGTCGACATCCATCAGGAGGTCACCCTTCTTGACACTCTCTCCCGCCTGGCACTTGGCGGTGAAGGGGCCTCCCTTGAGGTTGACGGTGTCGATGCCAATGTGGATCAGGATCTCGACGCCGCCCTCAGAGAGCAGGCCAATGGCATGACCGGTCTCGGCGACCATGGTGATGGACCCGTCTGCGGGTGCGAATACCTTGCCCTCGGTGGGCTCGACGGCCGCGCCCTTGCCCATGGCCTCGGAGGCGAAGACGGGATCGGAGACGGCGGTCATCGAGATGGCCTCGCCTGCCATGGGCGAGACAATGGCTTCGGGACCAGTGGCTGCGACTGCTTTGGCGCTGGGGGCCGCAGTGGTGCTGGTGCTGGTCTCAGGCTTGGGGGTGGGAGCGGCAACCTTCTTCTTGGGCTTGTCCTCGTCCTTGTAGATGGCGCTCGTGAGGCCAAAGGCCACGCCGAAGGCGACGACGAACATGATGATGTACTGGACGGGCTGCTTGACGCAGAGCAGGAGGCCGAAGATGCCCGTTACGCCCGTACCGGTGGCAGCGAGCTGGGTCAGGTAGCAGACGAAGGCACCGCAGGCGGCACCGGCCATGCCGCACACGAAGGGCTTGACCTTGGGGAGGTTGACGCCAAAGATTGCCGGCTCGGTGATGCCCAGTAGGCAGGAGATGCCAGAGGGGACCGCGAGGCTCTTGGTCTTAACGGTCTTGGTCTTGAGTGCGACGGCCAGGCAGGCACCGCCCTGCGCTATGTTGGCGGCGGACGCGATGGGCAGCCAACGTGTCACATTCCCAGGCTGGGCGAGCATGGAGACGTCGATGGCGGTGTACATCTGGTGCAGGCCCGTGACGACGGAGGGCGAGTAGATGAGGCCGATGATGATGTAGCCGATGCCTAGGGGCACCTTGAGCAGGAAGTACAGCAGGCCGAGGATGGCGTTCTCGAGCCAGACGAAGATGGGGCCTATGAAGAGGATCGTGATGTAGGCAGCGACCGAGACGGACACGAGCGGCGTCACGAAGAGGTCGAACATCTCGGGTACGGCCTTGTGCAGGCGCTTCTCGAAGAAGCAGAGGATCCAGACGCCCACGAGTATGGGGATGACGTGTCCCTGGTAGCCTATCCAGTCGATGCTGTAAAGGCCTGGTATCACCTGGAGCGTGATCATCGTGCCGTCGGAGAGGGCCTTGGAGGCGCTGTAGGCGCTGATGAAGTCGGAGCTGATGAGCAGGGCACCGAGCGACGCGCCAAGGTAGGGGTTGCCCCCAAAGACCGTGGCTGCCGAGAAGCCGAGTAGGATCTGCAGGTTTGCCAGGGCGCAGGCGTTGACGAGCGCCGCGATGCGCCACCATACGCTGGTGGTGTCCAGATCAAAGAGACCCGCGCCGTCGGGGGCGGGTGTGCCCATGAACTGGATGGCACCCATGATGCCCATGAGCATGCCGGATGCGACGATGGCGGGGATGATGGGTACGAAGACGTCAGAGAGTACCTTGATGGCCTTCATGAAGCCGTTCTGCTGCTGTGCGGCTGCCTCCTTGACGTCGGCCTTGCTCGCGGCGGAGATGTTGCCCTGCTTGCAGAGCTCCTCGTAGACCTTGTTGACAGTGCCTGTCCCGTAGATGACTTGGAGCTGACCAGAAGCCTTAAAGTTGCCCTTGGCGCCAACGGCGTCATCGACCTTCTCCTGGTCGACCTTGGAGTCGTCTGCGATGACCAAGCGCAGGCGTGTGGCGCAGTGCGCTGCCGAAACGATGTTGCCCGGGCCGCCGACCGCCTCCAGAATCTCCTTAGCGGCTTGTGCGTGATCAAGTGCCATTGAGTCCCCCTTGTCTGAACGCTACATATGGAATCGTTCTCACACGCTCTTATCGAAGGATTCCATAGTTGGTGGCAAACTCAGCTTGCAGCCATGGAATCGTTCTCATATATTCAAGAATACTTCACAACTGAGAGGATGTGGGTCCTAAAGGAGCGGGGCATAGCTGAACGGCGGCATATAGGCGGCGAATGGCGATGGATCGTCTTGCGTCGGAGGGGGACGAAGGATGCGTTCCCGAAAGACGAGAGGCGGATCGGGCTTGGCAGGCCATGAGCATGGTGCCGTAGGGGTTGGCCCCGCAGTCGGCTAAACCGAGCTTCACGGGTGTCCCTAGCGGATCGACCCCCGTGCGAGGACCTCGTAGCCCAGGCGTATCTCGCACGGGATGCGCGTCGTCTTGCCCATGGCGTCGACGAGCATGCGCGCGGCCTCCTTGCCGGCCGTCTTGTAGTGGTGGTGTACGGTCGTGAGCGTGGGCGTGACCACGAGCGTGAGCTCAGAGTCGCCCGTGCCCGTCACCTGCACGTCGTCAGGTATGCTCCTGCCGTATTCGCGCAGGCAGCTCATGGCGCCGAAGGCAATGGAGTCGCTCGCGCAGATGATGGTGTCCACGTCGGGATGCGACTCGATCAGTCGCTCACAGCTGAGGTAGCCCGACTCCACCGTGAAGTCTGCGATGAGCTGTGCGCTTGCGGACACCTCGAGGCCGTACTCCTCGCAGGCATCAAGGAAGCCCCTGTGTCTGGCTCTTCCTGCGGCTAGGTCCCGCTCCGTGACGCCGATGTAGGCGGGCTTTGTGGCGTGGTCGAGGGCCAGCGCCGTGATGTCGCGTATCGAGTGATAGTCATCGTTGTAGACGCAGGATCTCCCCTCGATGTCTTGGCCGAGGACCACGAGCGGTACTCGCAGCTCGTCCATGGCGCGCTCGTGCGCGGACGTGAGTACCGTGCCCACGAGGATGACGCCGTCCACGTGGTTCTTCTCGGCAAAGAGGCGCAGGTAATCGACCTCGAGCTTCTCATCATTGTCGGTGTTGGCCAGCAGTATCTGGTACTGGGAGTCGTTGAGCTGAGAGGTCAGACCCTCCACCATCCGCGAGATCGAGGCGGAGTTTATCTTGGGAATGATGACGCCCACGAGATTGGTCTTGCCGGTGCGCAGCTGCTTGGCCTGACGTGAGGGTATGTAGCCGGTCTCCTTGATGACGCGGGCGATGGCGCGGCGCTTCTCGCTCGAGACGTAGCCGTCGTTGAGGTAGCGCGACACGGTGGCGCGAGACACTCCCGCCATCTTGGCCACTGTCGTGATGTCCATGTGCCACCTCGCCTTCTGTTGTGTGACTCGAGAACCCTGTGATTAACTTACTTGCACAAGGTGGGCAAAACCGCACTCATTTTTTGGGTGTGCGGTCGCTGTGGCGCGGTGAGTGCGCTGTTGGCTCTGAAGGGTATGCGGGACATGCTCGCGGGTCTGCCTTAGGGACAGGGAGTTTGCTCACCCGGCGGTCATAGCTGAGAAGCCCGTTGGTCTCTTCCTCGATGTCCGTGAGCTGGGTGAAGACGAACCCTGCAAGCCCCCTTGGCTCGAGCGCGTCTGCCTGGGCGAGCTGCCTGGAGACTGCCTGTCGAAATGCTGCTGTGTCCTCGAAGACATCATAGCCGTAGGAGGTCTCCAGTGAGCAGTGCCCCTCCACGCGAAGACTGAGCCCACCGAACTCGTTGAGGATGAAGGCACGGTCATCCTTATGTGGATAGACCTGGAGGCTCCTGAAGTAGTTGTGGATGGCCACGAAGTTGCCCGCCCCCTGGTCGTACCAGCCGCTTGCCGCGATGACGGGACGCGTGGGGTCGAGCTCTCTGGTGCGCTGCGCCTGGCCAAAGGAGTCAAACTGCCCCCAGCTCTCGTTGAAGAGCGTCCAGGCAATGACGCTGGGATGGGCGGCGAGGCGACGCACGGTCAGGTCGCGGGTGTGCTGCCACTCCCTACGATAGGAGTTGTCGTCGGCTGCGAGCTTGCGCCAGTGGGAGGGCGTGTCGTCCCGAAAGCGCGACCATGAGCGCCTAAAGAGCGTGGGCGTGTTGATCGAGCGCCACTTGTCGTAGCTGCCGCCACCTGTGGGCATGTCCTGTATGACAAGCATGCCCATGCGGTCGCAGAGCCAGTACCAGAGCTCCCCCTCGACCTTCACATGCTTGCGGAGCAAGTTGAAGCCCAGGTCATGGGCAGTCTGGACGTCGGATCGCAGGGCGTCGAGCGAAGGCGGGGTCATAAGCCCGTCGGGCCAGTAGCCCTGGTCGAGCAGCCCCCTCAGGAAGATGGGCCTGTGGTTGAGCATGACGCGGGGCGTGCCTTGGGCGTCTGGCTCGACCGCGACCGAGCGAAAGGCGCAGTAACTCGTGACCTCATCCTCCCCATAGCCGAGCGTGAGGTCATAGAGGCGAGGGTTGTCCGGTTCCCAGAGCTGGGGGGCTTGGACGCGCAGCCTGACCGTCGCCTCGTGCTTTTTGGCGACGGGTCCCATCGCCGACCGGCCGCTCTTAAGCGAGAGGACCAGGCGTCTGCCAGGGTGGCTGACTTGGGCCGTGACCGAGATGGTGCCATCGTCCGGGTTGGCACTCACCTGCAGTTGTCGGACGTGGTCTTTGGGGACGTCCTCGATCCAGACACTCTGCCAGATGCCGGACTGAGCCGTATACCACATGTTGGCCCGCACGAGTCGCTGCTTGCCGCGAAGCTGCGTGCCCGTGTCGCTCGGGTCGAAGACGCAGACGGCCAGGGCGTTCTCTCCGTCCTTGACGGCGGACGTTACGTCTATGTCAAAGGGCAGGTAGCAACCCCTGTGCTCGGCGAGCCTCTTGCCGTTCAGATAGACCGCGCAGGCCCAGTCCACGCCCTCGAAGTGCAGGATGCGCCTGCGCCCCGGCAGGGGTCGGCTTGCATCGAAGCAGAGTCGGTACCAAAGGAGCTCATTTGGCTTGAGCTGGCGGCCGACGTGCGAGAGCTGGGCCTCTGGCGAGAAGGGCACGAGGATCTTGCCATTCCAGGAGATGGGCATCGCGGCGTTGCGCCAGGAGCTACGTGCTTCTTGGGCCGAGCCGAGCGAGACGAAGGCGTAGTCCCACCAGCCGTTGAGCGTCTGCCAAGATGTGCGGGCAAGCTGCGGGCGCGGGTGTTCTGGCCAGGGGACGGTGCCGTCGCCAGGAGTGGCGGCAAGGAGACTCTCTCCCCAGATCGTGGTCAGGGGGAAGAGGGGAGCGCCTATGCCCTCCTTGGGCTGGCTCTTGAGCGCACGTCTGAGATCGAGGTCCATGGACTCTCCTAAGTGGGTTTGCGAATGCAGAACAGGATAGTGCGCAAAGACGACCATGGGCCTTGCGAATTGTGAAGAAACACATATGAGAACATCGGTCATTTGACTTTGGTCGGTCTGGGGCATATAGTAATCGTCCTGCGCAGTTGATGCGCCCAGACTCTGCGGGGTGGAGCAGTCTGGTAGCTCGCCGGGCTCATAACCCGGAGGTCGGTGGTTCAAATCCGCCCCCCGCGACCAAATTTTCGTCCTCTGCCTGGTAAAACGGGTGGGGGATTTTCTTTGTCGATAGCTTGCCGAAAAACCGCGAGGGGCCCATATTTATCTGCTATTGGCCTACAGGTTTGCCCGCCTACTCTTTGGCATCCTCGATGTTGTGCGCATACGGCTTCCAGAGCGGGCACTCCTGCCAGCCTTTGGTGAAGCCCATGCGGCGGAGCTCACCGAAACTAAGGCGGCCCAAAAGTTTGAAGAGACGCTCACGCCAGAACGTCTCGGGCGCGATGTGCTCCAGCAGATAGCTCAGGATTGTGAGGATGCCAAACATGTTGTCCGACCTCACGCTGAAGGGCTCGTGCCATTCCGGATGCTTCGACCGCTTGGGAATGATTGGTCTGGTGCCGATGCCCCTGTTCCAGAGACGGCCATGGTGCGCGCATATGTTACGCACCGTGTTTATGGTCACGAGCCAAGATTCCAGCACGCGCGAGCTCACGCCCAAGTCGTTTGCGAGCTTGTTCCTGATTTCAGCTGGTGCGCCGTTGAAGAGCCTGAGCATGGTGCCGAAGTCCATCAGGTTGACGAGTATCCAGTAGGGAGGAAGCTCGTGCTCGTCGCTATAGGCCTCTTTGAAGTGGAGGGCGAAGGGCTCACGTGAGCGTCTGAGCTCATCCTTGCAGCGCGCTATGAACTTGTTATACTTGCCCTGCTTGAGCCTTGGCAGGTTGTTAGCGTCGAGGAATCCGAAGGCGCCGGTCTCTCTAGCAAGTTCGTATGCGAGCTGTGTGCGGAAGTAGACCTCCACGCGCTCTATGGCATCGAGTACGACAAGCCTGAACTGTCGGTCGAAGATGTAGAGGCGCCAGATCTGGTCGAATGACGTTCCCTCGATGAAGCGCTCGTCCTGCATGCCATCCTTGTCGCCTTTTGGCTGGCGCTTGAAGATGTACCAGTATCCGCTCAAGCGGTAGTAACCGATGTCAGCGAGGTGCCTGATAAGATCGTCACGGTCGGCCACGAGACCACGCTCGTTGATGAGAAGGTCTGCCTGCTGCTCGAAGGACAGCCAAGGTTTCGTGTACGTTCCCACGGTGCTCATGCACCTCCAGACAAAGAAGACCCGCCAGTGTGCATGCTCGGAAGCAGAGGCCAGGCGGGTTTACTGACCACAGTGTATCACATCCATCGTGAGACGGCGCGGAAGAGCCAGCGCACGAAGCGCCAGACGAGCCTAAAGACGCCCGTGTCTAGCCTCCTTCTCCTCTGCGGCGGCGAGCATAGCCTTGAGCTGGTCCACCGAGAAGCTGAGCGCGGGCTCGCGTCGCTTTGGCGTGCCGATGACGCTGTCCATGATGGCGTTGCCGTAGCCGCTCATCTCGGCGCCGAAGCTCTCCTCGACCTTGCTCACGGCGGCGCGCTTGGCCTCGGGGTCCACGTCGGCATAGATGTCCAGGGTCATGGACACGCTCGCGTGCCCCAGGTAGCTCGCCACGGTCCTCACGTCGCAGCCGCCCGCGATCATCATGGTGGCGAAGGTGTGTCTGAGGTCGTGGAAGGTGCACTTGAAGCCGTTCATCTTGCAGAAGGCGGCAAAGTCCTTGCCGAGCTGCGTGGGGTTGTAGGGGCGGCTCTTCTCCTCCTGCGTGCCCAGTATGTAGGGGTCGCCGAAGGGGAGCGCGAACTCGTTGGCGATGCGCACGGCGTCCGCCCGCACGAGGCGCAGCATGTCGAAGGTGCGCCTGGTGAGGGGAATCGTCCTCAGCGAGCTCGAGGTCTTGGGCTCCTTCACGTAGAAGCCGCCCGGACCGTTTCCCAGGGCGTGGCTCACGGTTATGGTGCCGTCGTCCGAGCGGTCGGACCACCTGAGCGCGCAGACCTCGCCGCGCCTCATGCCCGTGGTGAGCGCGAGCTCTGTTGGGCCGTGGGCTTGGGTTGTGGGTGGCCTTGGGATCGCAATAGTGTACACAAATGGGAGGATCGGGCCTCTCCGCGCCGGATTGGGTCATTTGTGTACACTGTTGCGACGCGAGTCGCGATACGAATCGCGACGCGAGCTGTGCCAGGTGGCACGAGCGCCTCAGCCGTCATGGCGTGTCGGCGGCGCCTCCTCGCTGGCCCCTCTCGCTTGGTCGGGAAGACAGGCTCTGCGCGAGTGGCGCCGCTGCCAGGTTGGCATCTTGGCCGAGGCGTCAACCCACACGAACCCCCGAAGAGTCTCTTACTATCGACAGTTCCTAAGACGAGCGGCGCCGAATCGTTCGAGGTCGGCGGAACGTGGGAGACCTGGCCGACGATCACGCTTGTAGCTGAGGCCGGGAGTGCGGTCTCCGTGGGCGACGGGAGCTCTTCCGTCGCTGTGGAAGGCACCTTCGCCGCCGGCGATGTGGTGGTCATCGACATGGAGCGGCAGGCAGTGACCGTGAACGGGGCCGATGCCACGGCGCGGGTCTCGCTCGAATCTGACTTCTTCGCGCTGGTACCCGGTGGAAAATGCCTTGGTCTTCTCGGGTTGTTCTTTTCACTCCGTGAGCTGGGTCGAGAGGTGGGCCTGATGGCAGTCCCGACCCTCTACCTCTTCGACCGGTGGGACGAGCGGCTGGGGGTGCTGCCGACCCTGGGCTTCATGACGCATACTGAGGGGCTGGGAGGCGAGGACACGCTGGAGTTCGGCTGCCTGGTGGCGCCTGAGAAGGGCGACCGGCTGGTGTGGCGGGACCCCGACACCGGGGCCTGGCGCGAGCACGAGGTTGTGAGGACCGACGAGGAGACGGCGGGCATTGCGCACGTCTATGCCGAGAGTTCATTGTGCGAGCTGCTGCGCGATTTCGTGGAAGAGGAGCAGCTGGTAGCCAAGACTGTCTCGCAGGCCATGGCGGTGGTCGCTCACACGCGATGGTCACTGGGCACGGTGAGTTGCGATGATTCCACCAAGCGCGGGGCGCTGCTCTGCCACTCGAACGCCTTGGCAGCCTTGCGCAGGGTCGAGTCCGTCTGGGACGGGGAGCTGGAGTGCTCGTATGAGGTCTCGGACGGCCGGATTTCCAAGCGGACTGTCTCCTTGCGTATGTCTGCGACGACCGAGGGCGTGGGGTTCCAGCACCTCTCGGGCATGACGACCGCGAAGCAGTGCTTCGTCTCGCGCACGGACCTGGAGTCCGTCTACGCCACCTTCTTCGACACGTCGGCGCTCACGGCGGGCTACCAGATGTTCTACGGCTGTCAGAAGTTGGTCGGGGGAACCGATAGGACCGTGGTGGGGAACTTGACCGCCTACTCCATCTGCAAGCTCGGGGAGGGCGGCGTGCTGACGGACCCCGGCAACGACACGAGGCAGTGGTTCTGGGGGACGGTCTACGCGGACGGGTACCTGGAGATCTCGGCGAGCTCGGACGTTACGTGGTCGCGCGGGGTCGCGGGGCGCGGGCGGACCGCGCCTAGGCCAAGTACCAGCTGGCCTCAGGGCTGCCGTGGTCGGACGAGAAGGACCGCCTCACCAAGGTCAAGGTGAAGGCCGACATGGCGACGGCGGGGTTCACAGAGCTCAACATGAACTACTGGTTCTATGCGTATGGGGACGTGACAAGCTTCGAGGGGCTGGGGAACCTGAGGCTCGTCTCGCGGATGCGGCATGCGTTCTCGTCGTGCACGGCTGTGACGGAGCTCGACCTAACGGGCTTCGACCCCTCCTCGCTCACGGACCTCTTCTACGCCTTCGCGGGGTGCTCGGCGCTCACGACGATCTACGTGGATGCGGACTGGGCCCTGCCCTCCGGCTGCACTGGGAACCAGTGCTTCTACAGCTGCAAGAGCCTCGTGGGCGGGAACGGCACGGCCCGGGCTAGCGGAAAGACCGGGATGGCCTACTGCGTGGTGGACAAGGACGGGCAGGCGGGGTACCTCACGGCGAAGGCCTAGGAGACAGCCTTCTCGACCTACTCGACGAGCTGCTCGTAGGACATGCTGCCGTCGGCGACCGCTGGCATCGCCCGCAGGAAGTCGTCGTGGCGGGCTTGAAGTGGTGGCCGCAGAGGCGCAGGGATGCTCCCAGAAGGGCGGCCCCCGTGCGCTTGTTGCCGTCGGTGAAGGGGTGGTTGCGGATCACGCCGTAGTACAGGCGACAGACCTTGGCGACGTCGCCCTCGTAGAGGTCCCGGCCACCGAAGGTCTGCCAGGGCTGAGCCAGGGCCGAGTCGAGCAGGCCCTCGTCGCGCACGCCGGGAAGGCCGCCGAAGCGCGCGATGGCCACGTCGTGGATGGCGATGACCTGGTCCTTTGCGACGAGCGGGTCCTGCGGGGCGTTCACTTGGCCAGCTCCCGGAAGACGTCGGCGTACTCGTCCATGAAGTCGACGGCCACGTCCACGGCGTCTGTCTGGGCGGCCCCCGCTGCCGGCTGGATGACAACCCAGGGCCTATTGTTCTTGAGCACGGTGACGGGACGGCCCGTGCGGTTGACCTCGGCCGTGACCTTGGAGAAGTTGTTCTTGGCCTCCGCGAGGCCCATCGTGACGGCAGGCATGGGCGTCCCTTTCCGAGAGTTCTTGTAACTAGCCAGAATTATAGCCATATATGTGGCCTTCTCAAGCGTTTGTGACGGGGTTGGAGGATGAATGCATTGGATGGCGTCGCAGGGAGGGCTTTCTCGTATGGAGTCGGTATTGGTGGCGCTCATTGGAGGCGCGGTGACGCCGGCTGGCGTGGTGGCGTCGAACTTGCCATGGCGGCCAGGTGGAGTGGCAGGCAGTGCGCGGACTACTTCGCTGGGACGACTCGGCAGGCGTCCTCGAACTACTGCATCGGGGTCGACGGCGACGTGGTCATGAGCATGGACGAGGACGACCGGGCCTGGACGTCGAGCAGCGCTTGGAACGACAGGCGGGCCATCACCATCGAGTGCGGGAACATCGATAACTCCACGGGAGAGATGAGCCAGAAGACATGGGACACCTTGGTCGGACTTTGCGCGGACATCTGCACGCGGTACGGGTTTCGGCTCAACTACACGGGCGACCGGAACGGGAGCCTGACCGAGCACCGCATGTTCGCCTCGACCGCCTGCCTGGGGGCGCGGCTGCATGCCCGCATGGGGAAGCTAGCGAGTGAGGTTAACGCGCGGCTGGACGGCGGCTCCACGAAATCGGACAGCAAGTCCGGGAGCTCCGACGTGTACCTCGTGAAGGTGACCTGCGACGCGCTGAACATCCGCAAGGGGCCCGGAACGGGCTATGCCGTCGTCGGCTGTATCCGCAGCCGGGGGACGTACACCATCGTGGGGACCTCCGGCAACTGGGGCCGCCTGAAGTCCGGCGCGGGCTGGATCTGCCTAGACTACACCTCTCGGGCGGGATCCGCGAAGGCCTCTTCCGCCAAGGCCGCGGACATCGATGCCATGGCTCGCGCCGTGATCCGGGGCGACTACGGCAGCGGCGAGGAGCGCAGGTGCCGTCTGGGCGAGAAATACGCAGCGGTGCAGCGGCGCGTGAACGAGCTGCTGAAATGAGAGGCCGTCTGCATGAGGAGCTGGCTTGGGGCTTGGCTGACATTCTGGCCCTTGTGTTCTGCCTGCTTGTCGCTCCGCTGGCGCTGCTGCTTTGGCTCATGTATGGCCGTCATTGACGACAGCGGGGTACGCAGCGCCCCGCTGCCTGCCCTTGCAGGTGCGTGACCGTCGCACGGGTTTTCAATGCCGCGTGTCCTTTGCGCGGTGTTGGAAACCCCTCCGGCTTGCCCGTAGGTCCGGCGGCCCAAACCTCGCACGAGTTTCCAACAGCGCGGCGCGGCTGCGGCTTGAGGCAGGGACCTCTGCCGCGCCGCGCCGTTGGAAACTCTTGGTGGCTGCCTTGGTGGTATGAAGCAGCGTCGTGACCCACTTGGGATGCGGCGCTGCTCTTATCCATGCTGGTTTGTTAATCGCATCTCTCGGCCACGCTATCCTTCGGCTGCTTGTCCTTCGGTCCCCTCCTTGACGTCCGCGTTCTCTTCCCCTGGGTCCAGTCTTACCAGGATTGTTTGCACGGTCTCCGAGTCTTCGATCCTCGTGATGCCGAATACCTTCTTGCCCGCGTCCTTGAGGGATGCACCGACAAGGTAGGTCTCCGTGCCGTCTAGGATGATGAGGCGGTCGTGGAAGGACTCCGTGCGCCTGACCGTAAGTTCGGGGTACTGGGCGTTGAAGGTCTCGATGTCTTTGGCAGTGAGCTTGGCTTTGGGGTGGGTCCAGAGCGTTACGGAGACGCCGTCGTTTTTCTTTGCCAGGATGTTGAGGGTGCCTGCGTCGGTGTAGCCGTCTACGAGGAGGACGCCCTTCTTGGCACGCTGGACGAGAGAGACCAAGAGTTCGAAGGCGTCCCAGACCTGGCCCTCGAAGAATACCTTCTGCCTGGGGGCCTCGTGCGATTCCATGTAGTCGAAGACGCGCTCGAAGCGCTCGTCGGTCTTCTGCTGGTACTCGATCTGGCGTCGCTCGACGTTGCGGACCTGCTCGAACATGTGGGCGTTGTCGGCGATGAAGTGGCGCATCTCGACGAAGGCGCGCATGATCTGCACGCTCACGCGCACCGCAGCTTCGCTTCTGAGCACTGCCGAGAGCATCGAGACGCCCTGCTCGGTGTAGGCGTATGGCATGTAGCGTCGCCCGCCGCGTCCGTCTCCGTTGTTTGAGGTGCCAATTTGGCACCTCAAAGATTCGAATTCATCGTGACCCAATTTGAACCTGAAATCTTCGGGGAAACGCGCCGAGTTGCGCGAGGCGGCACGATTGAGCGCCTTGGTCTCCACTCCGTAGAGCTCTGCGAGGTCGCTGTCGAGCATGACCTGCCTGCCGCGCACGGTGTGGATCATGCTGCGGGTCCGGGCGTCGACCACGGGGACGATGGCGTCTCGCCCCTCGCCCGACCCGGTCTTCTCGTCTGCCATGTCCTCCCTTTCCTCCGCTTGAGGTCACATCCTGTGCCTTCAAGGTTCTACCAAGTTCCAAATGGTTCGGACTTGTCGGTTGCCTATGCTCGCATCAACCTGAGCGCCGCCTTGGCGATGAGCCTGATAGCTTTGACCAGCACCCTAAGCACCCGCACGGCCGTCCTCCTTGAGACTGCTCCACCTGAGCGTACACCTTGCTGCAGCGCATGTCGGTGGCGAGTTCGAGCGGGTTTTATCCCTCGGCGGCAACTGAGGCCTCAAACATACGTTTTTGCATGTCCGAATCACGTCGCTTCTCGCCAGCCTTCCGTGCGGGATGCTTACTATCATCTGTGAAGATTCCCAGAGTGGGGCCTTTGGCGGCCATGAAGCCGTCGTTGTTCCCCTCGTCTCTAGCGGCTTGCAATGCCTGAGTCCAATTTTTATCGGAAACAGTGTTCCCTATGGTGTATTATCAACGGAAACGTTGTTACCGATATGAGGAGTGGACATGGACAAGAAGGGCACGGTGCGGCGATTGTTCGTGCTCATGGGCGGCTATCGCTGGCTCGAGATTGTCAGCATGGCAACCGTGGCGGCCTCTGCGGCCATGAACCTGCTCGCTTACGTGCGCGTATACTACGTGGGAGAAGCTGTGCTCACGACAGCCGGTGACCTTTCCTCAATCGACCGGCAAGCGATAGCGGCCCTCGGTTGGGACGCGGTGCTGTTTATCATGGCGGCATTCGGGATATACGGCATCGGCCTGCTCTTCTCGCATCTGACGGCGTTCAACACGGTTGCCCGTCTGCGCGACCGCATCGTGTGCCACTTGGGGCGGGTCCCCTTGGGCTACCACGTGGCAAATCCCTCGGGCAAGCTGCGCAAGATAATCGAGAAGAACACCGATAACATCGAAAACACCATCGCGCACACCATGCCCGACTTCGTTAATGCCATTGCACTGCCGGTCGCGTATATCGCGTGCATGTTCGCCTTCGACTGGCGTCTTTCGCTCGCCTGCCTAGCGCCCCTGGTCGCAGGGTTCTTCGTGCTGGCGTGGATGCTGAACGACTCGAGCAAGTCCTTCTACGCCAAGCAGCAGAAGTCGGCAGAGGACATGGCGAGCGCCACCACCGAGTACGTACGCGGCATCGCCGTGGTGAAGGTGTTCGGCCAAACGGCGGAGTCGTTCAAGCGCTATCACGACTCGGTGGAAGAGCACCGATCATGGATGCTCAAATACGCGCTCTCCATGCGCCTGCCGGACAGCCTCTACACCGTCACCATCAACGCGGGGTTCCTGTTTCTCATCCCAACCGCCATCGTCCTGCACGACAGCGCGAAAGGCGGTGCGGCGGCAACCACAGCAGCGGCGACCTTCATCTTCTTCTGCGTGCTCATCCCCATGACTGTGACCATGCTTACGCGCATCATGAACGCGGCGTCGAACCTCATGGTTTCCAGCGCGTCGCTCGACGCCGTGGACGACATTCTCACCCAGCCCGTGCTGGAACGCCCTCTTGCCCCGAAGGAGCCTGAGTGCTTCGACATAGCCTTGGATCACGTCTCATTCCGCTACAAGCCCGACTCTCCTCTCGCGCTCGACGATGTGACGCTGCGCATTCCCGCCGGCGCCGTGTGCGCCCTCGTGGGGCAATCGGGAGGGGGTAAGACCACCGTGGCCAATCTGATCGCGCGCTTCTGGGATGTTCAGGAAGGAACCGTGCGCATCGGGGGAGACGATGTGCGCGAGATGGACTACGCCTGGCTGGCTGCGCACACGAGCATCGTCTTTCAGGACACGCGGCTGTTCAAGGCCTCCATCGCGGACAACGTGGCGTATGCGAAGCCTACCGCTTCGCGGGAAGAGGTGCTGCGGGCCCTCCATCTGGCGCAATGCGACGATATCCTCCAAAAATTCCCCAACGGGGCCGACGCTGTCGTAGGCGCGCGAGGCGTGTACCTGTCCGGTGGGGAGATGCAGCGCATCGCTCTGGCACGCGCCATGCTCAAAGATGCCCCCATCGTGCTGCTCGACGAGGCGACCGCTTATTCCGACGCCGAAAACGAGCATCTTATCCAGCAGGCGCTGTCCAAGCTGCTGCGCGGAAAGACCGTGCTCATGGTTGCCCACCGCCTCTCTACCGTGGTCGACGCCGACCAGATATGCGTGGTGGAGAACGGACGCATCGTCGAGAGGGGCGTGCACGACGAGCTTATAGCGCAGGCTGGTTTTTATGCTCGCATGTACAAGGAGTACGAGCGGAGCGTGGAATGGAAGATCGGAGGGGCCGCATGATGGGCAATCCGCTGCAGAAAGCTTTGCGCGTAAGCGACGAGGGCAATGCCAACCTGCTGCGGGCGAGCGCGTGGATGTGCGCTTTCAGGCTCGCCGCCTTCCTTCCCGTCATACTACTCGCGATGATAGCGAACGAGATGGTCGTTCGGAGCGCGGGCGCAAACGCCCAGGACGTACCGCTTCTGCCCTATCTGGGGGCAGCGGCGGCGTTGGTCGTCGTCATGTTCTTGGCGTATTGGGTATCGTACAAAAGTAAATACCTGAGTGCGGGAGACGAGGATGCCCGCATGCGCATCGCGCTTGCCGAAAGAATCCGTCGGCTCCCCATGTCCTATCTGGGGAAGCGCGACCTCTCCGACTTCACCTCCGCAGTCATGGACGACGTCGACACCGTGCAGGGCGTGCTCGCGACTTCGTTTGTCGAGCTGGTGAGCGGCCTGCTGTTCGCTCTGGCAAGCATCGTCTGCCTGCTTGTCGTCGACTGGCGCATGACGCTTGCGCTTGCCGCATGTCTCCCGCTTGCCGCCCTGTTCATGGCCCTGTCCCGTTTGATCTCCGAGGGACAGAACAGGCGCAACCGCGCAAGGCGCCTGCAGATGAGCGAGGCGATGCAGGAGTATCTGGAAAACATGCAGGAGCTGCACGCTCTCAACCTGATGAATGGCTACCAAGGCAAGATTCGCCGTGCGTCCAGAAAACTGGTGCCCGGGCTGGTCCTATACGAGCTGCTGGCCGGTCTGGGGATCTCGTTCGGTGAGAATTTCCTGCGCTGCGGCATGGGCGTGGTGATCGTCTACGGTGCAGCGCGGATGGCATCGGGGGATTTGGGCACGTTCGAGTTTCTCCTCTTCCTGTTCGCCTCGGTGCGCCTGTACGAACCGCTCTGCGTCGCCATCGAGCGGCTGGGCGCCATCATTCATGCGCTCGTGGCATCCCAGCGTATCGGCGAGATACTGGACCATCCCGTTCAGGAGGGGGACGGCGACGTCCACCCGAGGGCGTATGATCTCGAATTCGACCACGTGACATTCGCCTATGGCGAGGACGACGTCATCCACGACGCGTCTTTTACCGCCCCGCAGGGACAGACAACCGCACTCGTGGGGCCTTCGGGCTGCGGGAAGTCGACGCTATGCAGACTCGCCGCGCGCTTCTGGGATGTGGATAGGGGCACGGTGCGCATGGGTGGCATCGACATAGGCGGCATCGACCCCGAGACGCTCCTGCGCAGCTACGCGTTCGTGTTTCAAGACGTGGTGCTGTTCGATGACACGATAGCGAACAACATCCGCATCGGACGCGCGGGGGCAACCGACGAGGAGGTGCGTGAGGCCGCGCGGGCCGCATGCTGCGACGAGTTCGTAGAAAAGCTCCCGCACGGCTACGAGACCATCGTGGGCGAAAACGGTCGCACGCTCTCGGGAGGGCAGCGACAGCGCATATCCATCGCCCGCGCCCTGCTGAAGGATGCGCCGATCGTGCTACTCGACGAGGCGACCGCGTCCGTCGACCCTGAGAACGAGACACATATCCAGCAGGCTCTGGGGGCGCTCGTGAAAAACAAGACCGTGCTCGTTGTGGCCCATCGGCTGCGCTCGATCGCCGGCTGCGACCACATCGTCGTGCTTCAGGAGGGTACCGTCGTCGAAGAGGGCGTCCACGAGCAGCTGATGGGCGCGAAGGGGCTGTACAGCCGCCTGTTCGCGCTGCAAACAAAAAGCGCTTCGTGGTCGGCGGGGCGAGACGGGAACGACGTGCGATGAGCGGGCGGGCATGCATGCCAAAGACAGGGCTTCTACCGCATGTCGAGCATTCGCGAACACCAGGCCTTGATACGTGTATCGGAGAGCTTTTCGACAGGGAGCCGCCCCGCCTGGATGCCCGCGTGAAAGTCGCCGCGTTGCTGGCCGTGAACGTGGCTGCGGTACTCAACCGCAGCTTCTCGGTCGAGATCGCTGTCATGGCGTGCATCGTGGCGGCTCTTCTGTACAGCAGGCTCAACCGCACGGCCATACGCTGCGCCGCCACCTACGCGGCGGCGGTGATCATCATGGCGTTTGCGGGCGGCGAGAACGGCATCGCCTCGGTCTTGCTGGTCGTCGCCATGGTCATCCGCAAGACCACGCCCATCTTCGGGTTCGGCTACTGCCTGGTCGCCACCACCAAGATAAGCGAGCTGTTGGTGGTCATGCAGAAGCTCCGTCTTCCCAACAGCATCACCATCCCGTTCTCGGTCGTCTTGAGCTACTTCCCCTCGCTGGCTTCGGAATGGCGCAATGTGACAGGGGCGATGAAGATGCGCGGCTTCGGTGTGTCGCCCAAAAACGTCGCGTTCCATCTTGTGCGCACGATGGAGTATGTCATGGTGCCCATAATCGTGCGCAGCGCGACCGTCGCCGAGGAAATCTCTGCCGCCGCCATAACGCGCGGCATCGAGGCGCAGGATGTGCGCACCACGGTCTACCCCATGGAGATCGATCTTGCGGATGCCATATGCCTTGTGGCATGCACATGCCTGGTGGCGGCAGCGGTGGCAAGCCGCGTGGGAGCAATCGCATGATAGAGATCTCGAATCTCGGTTTCTCCTACGAGGGCGGCAACGGCGCATGCCTGCAGGATGTCAGCCTCTCCGTGAAAAGCGGTGAAGTCGTCGTGGTCACGGGGAAGAGCGGCTCGGGAAAGACCACCCTCATCCGCGCCTTGAACGGGCTCATTCCCCACTACTACGAAGGGTACATGACCGGTTCGGTGAGTGTAGGCGGCCAGGCGCTCTCCAGCCTTCCCATGCCTGCGATCGCGCGCATGGTGGGGAGCGTGTTCCAAAATCCTCGAAGTCAGTTCTTCAATACCGACACGGTAACCGAGATCGCGTTCGGGTTGGAGAACCTCGGCATGCCGACTGAAGAGATACGCCGGCGCGTCGAACGTGCGGTGGTCGACCTGGACATAGAGACCCTGATGGGAAAGAGCGTGTTCGAGCTTTCCGGTGGCGAGAAGCAGATCGTGGCCATCGCCGCCGCCTACGCGCTCGGCCCCGACGTGTTCGTGATGGACGAGCCGAGCGCCAATCTCGACTTCGATGCAACCAGGCGCCTCGGGCGGCTTGTGGAACGGCTGAAAGAGTGTGGCAAGACCGTGGTGGTCTCCGAGCATCGCGTGTACTACCTAAAAGACGCCGTGGACCGCTGCGTGTACCTTCAAGATGGGCGAGTGAGCCATGAGTTCAGCCGAGACGGATACCTGGCGCTTTCGTCTGGCGACCAAGCGGCACTGGGGCTGCGCAGTCTCGACCTGAGCCTCGTGGAGGCGCAGGTGGCGACAGCCCAGCCGGAGCACGACAGCCAAACGGGGGCTCCCCTGCGCGTAGAAGGGCTTCGCGGCGGATACCGAAGGCGAGAGACGTTGCGCGGCGTAGACATCGAGGTGCTGGCAGGCAGAACCGTCTGCCTGCTGGGGAAGAACGGCGCAGGAAAATCCACGTTGGCAAGCATGCTCTGCGGCCTTGTGCGCGAGCGCGCGGGCCTCGTGTCGGTAGGCCGCGAGCTTTCGTTCAGGCGGCGCGCGGGTCGATTCTTCCTCATCATGCAGGACGCAGGGAGCCAGCTTTTCAGCGATACCGTTGCAGGTGAGCTTGCGATGTCCGACGCGAAGGGCAGCCTGACCGTTAAGGCCACCGCCGCTTTGCTTGAAGAGCTGGGGCTGGGTGGCACGCTCTCCAGGCATCCGCTCTCGCTTTCGGGAGGCGAGAAGCAACGCCTCGCCATCGCCACGGCGATCGTGGCGGAGCCCGACGTGGTGATACTCGACGAACCGACAAGCGGGCTCGACTTCGCCAACATGCAGCGGATCGCCCAGGCGATACGGCGCCTGGCGCGCAGAGGAACGCGCGTCTTGATCATAACGCATGACTACGAGTTCATCTGCCGTATGGCCGACGATATCGCGATGCTGGAATCCGGCCGGGTGACCTGCACGTATCCGCTTGACACAGAGCATGCGGCGCTCCTGCGCGCGTGGTTTTCGATCGGGTGAGCAAAGGGTGAGCCGAGAGGGCAAGACCCACAGGCTCCCTTTGACCGAAAGGAAGGAAGAATGAAAGAGAACAAAGATGCGGGAATGCCGGCGCAGGCCGTGAGAACGGGCGGCACAGGCAAGAAGATGTCGACCAAAGACTACGTCACCGTGGGCATCTTCGCCCTCTTGCATACGGCGGTGCTGTTCATCGTGGGCGCGATAGGTGGTCTGTCCGCCGTCGGATTCCCGCTGTTCGGCCTTGTCGGCTTCGTCCCCGGTGGCATCATCTTCGTCTACATCGTGACAAAGGTTCCCAAACGCGGGGCCGTGTTCGGCCTCGGCGCCATCTCGGCGCTAGTTAACTTCCTCATAGGGGCATACGGGCCCGTTCCGTTGTTCGTTCTAATGGCCGGCATTGTGGGCGAGGTGGTCGTGTCGGCAGGCAGGTACAAGAGTTTTCCCCTCATCGTCGCAGGATACGTCCTGTTCGCGTTGCTTATCTGGTTCGGCTTCATGTCGCCGATCGCATTCTCCATGGAAGGCTACATGGATTCAGCGGTCAAGAGCTACGGCGTCGACTACATGGCGACGCTCGCCGGATGCGTGCAGGGGCCGCTTCTGATGGCGTTCGGCGCCGCGACGACGGTGGGCGCCGTGGCAGGAACCCTCTTAGGGCGCAGGCTGTTCGCCAAGCACTTCTCGCGCATCGTTGGCTAGCGCGGCCACCGTCGGTCAAGGCAAGGGGCCTTCGCACGGGGCGCGGGCGCGTGCTGGAGCGGCCGCAGGCAAAGCAACAAAGCAGGGACATCATGCCTACCCTATAATAACGAGGTCGGATCTAATTCGATCCCTAGGTGAAAGAGGGGTGTCGCGTGGCGAAACGTGCCGAAGGCACAACGGAAAAGCTTCTTGCAAGCGCGCGGAGGGAGTTTTCCCGGCATGGGTTCGCGAATGCGTCGCTGCGCACCATCGCCCTCGATTCGGGAGTGACCACGCATACCGTGTACACGCGTTTCGACAACAAAGAAGGACTGTTCGCCGCGTTGGTTGGGCCGGCGGCAGGCAAGTTCATGGAAACCCTCATGGCGGGCTACGATAGGTATTTCGACATGGGGAACGAGTCAATCCGAGAACGCGAGCTGTTCTCGCACTCCGTATATGAGGAACTAGTCGACTTGATGTTCGACAACCGCGACGCGTTCATGCTGCTACTGGATGCCTCGGCGGGCACCGCGTTCGAGCACTACGTGGAAAAGGTCGCCGAACAGCCTTGCCGGCGCATCTACGCCCAGTCCGACGTTTTGGGGATGCCGCTTGACGACGACCAGCGGCTGCTTGTCCACGTGCTCACGCGCGGCTTCTTCGACGGCATGTTCGAGACACTGCGACACGGCCTGGACCGCCGGTCCGCCCAGGCGTTCGTCTCCGAGCTCATCTCATTCTATGAAGGCGGCCTGGCGAAGGCGAGCTTGGGACAGGCAGCAGGTTTCGGCGGGCTCGTGAAGGAGCTGGGATGACGGCGGACAAAGACGTCGCGTGTCTCGCCGACGATCACCAGGCATCGGCATCCGGATGGGAAACGACTTTTCCTCGGCATGAAAGATGAGCGCCCTTCGGCGCATGTCCTCGGGCCCGTGGTTCGCGGTAAGTTTCTGCCGTCGTTGCAAGAGGCGTTCGCGCCGCATTCATGGAAGGGGTCGCCATGGCGGAATATACCATCAGCTCTGATTATCCCTAGTTCTTTCTGATTGTAGAACTACCGCCTGATCAAACCAAAGAAAATCGAGAAAATCGCAGGTCGAGGCCCCAAGGGGCCTCTCTTGTGCTATATTATATGTAGTGCTACTTACTACTTCCTGTGTGGCACGGGAGGCGACCGGGATGCCGTTCATAAAGGTGCAGAAGCTGGTCAGGGACGAGTCCGGCGCAATCAGGAGCGGGTCCGCCGCCGTGGTCGACACGTCGTACGTGCGCGGCGCCAAGTACCACTCGGCGCAGGCGGTGCGCGAGAGGCTGGGCAAGGTCGTCTGGCTCGCGGACGACAGGCGCTCGGGCGTGTTCGCGTCACCGACGCGCGGCCTGGTGGAGTACGACGCGGACGCCGACGGATTCGCGCCGGTGGCCAAGGGCGACGAGCGGCTGGCGAACACGGGCGCGTTCCCCGAGCCGCCGCGGCACCTGGAGCTCGGCCCCGAGCACCTGCTGCTGTCGTTCCTGGGCGCCGATGGGGTCGCGGGGTGCCTCAGGGAGGCGCTCCCCGACGACCGGTCCTACCAGCGCGCCCTCGCCCACGTCACGCACGGCGTGGTGCGGGACGGGAGCCGCGAGACCTGCGACAACATGGTGGCCAGGTCCTTCGCGGCTCTGGCGCTGCCGGGCGTGCCGCCCGCGTCGCTGAGATCGGACACGGCGTTCTTCTCGGCGATGGGCGCCGACGGGGCGAAGGTCGCGTTCTTCAGGGCGTTCGCCAGGCTCATGAGGAGGACGAAGCCCGGCTTCGGCCGCGCATGCTACGTGGACTCCACCCCGCTCCCGAACGACGCGGTCGACAACCCGCTCAACGCCCTCTGCAGCCACGGGCTGAGGGGCGCGGCGGTCCAGATGCGCCTCGCGCTCGTGCTCGACGAGACGACGGGGCTGCCCGTCTGGTACGAGGTCGTGCCCGGCAACGTACTTGACCTCTCGACCATAAAGACCGTGATGGGCGACGTCCTCGCCACGCTCGGCATCGAGGTCGTAACCGCGGTCCTCGACGCGGGCTACGCGTCGCGCGAGCTGCTCGAGGCCTTCTCCGAGGGCGAGAGGGACGTGCTGGTCAGGATGCCGGCGAGGAGGGGGTACCCGTACCGCGAGCTCTGGCGGGGCGTCCGCTCTCTGATCGGCAAGGGCAAGTACGCGATCACGCGCTCCGGCCACCTCTACTTCGCCAGGAGGCGCGACGTCGAGGTGCAGGGCGTGAGGCTGCACTGCTACGTCTACGTGGACCAGACCAACGCCACGCCGCGCTTCGCCAGGTGGCTGGACAAGAACCAGGAGAGGTTCGACGGGATGTCGCTCGCCGAGAAGGACTGGGAGACCGTGCGGCAGGGCTACTTCGTGCTGATGTCCACCAAGGTCGCGACGCCCCGCGAGATCCTGGACGAGTACTTCTGCCGCACCGAGATCGAGGGCGTCTTCAAGACCAGCAAGGACTACCTGGGCCTGCTGCCGCTGCGCAAGTGGAGCGACCTCACCGTGCGCGGCAAGATCCTCGCCGACATCATCGGCACCATCGTGGTGCTCAGGATGCGCAAGGCGCTCGCCGGGGCCGACGTCTCCCTCACCGAGGTATGGGGCAAGGCCAGGTCGCTGTCCTGCTACACCAACGCCGACGGCAGGGTCGTGGTCGAGACGCCGTCGAGGCAGGTCCGCGAGTACTACAAGGCGCTCGGGGTGAAGGTGCCCTCGTCAATCGACGTCAGGGAATTCGACCGTGACGTCCTCGGCCTGGAGCTGTAGTTCTACAATTAGCGTCATCTAGGGATTATGGTTCGCGCTGTTAAGGATGGGCGTGCACGCGCGGTCCGTCACGGCGAGGGGGTTCGGCTTCGCGTGGGCAGCGGACTGACTTTCGAGCGCTGCGTAATACGCGGTGGCTGTGCCCGTGATGATGCCCGGGTGCGCTCCTAGTCGTTGCGTCACTGCCCTCCTGTGATGTGTGGGCTGCGGCGCCCGCTATGTCATTGCGTCTGGCGTCTGGTCGGGAGGGGAGCGCATCCGTCGGCGCTCATGTCGCGCATCTAGAAGGACGTGCCCGGTATAGAGAGCTCGGCGAGCCTCACGCTGCCGAGGTAGCGGCAGATGATGCGCGTCTCGGCGCGGTAGCCCCGCACCGTGGAGGGCTCGATGGTGCCGGAGTCCTCCTTGTGGCGCATGAACGAGGCCATGAAGTTCCTGAGGGAGACGTTGGAGGACGACGCCCCCTCCCAAGAGCTCGAGCTCAACGATGAGGGCGTCGCGTGCGCGCTCCGCCTCGTGCGACCTCTCGTCGACGTTCGTTCCCATGACTATCTGCCCCCTCGTGTTGGGGCCCGCCCCTTGGCGCGCCTTGCGGGGCGGATGGCGCCTGCGGGCAAGCGACAGTGCAAGGGATGAAAGCGAAACGCGGATGCGCCTTGAGTTTCCCAAAGGATCGCCTGCGGCCCTTCGGGAAAGCTTTCGCGGCCCTTGCGCGGAAGCGTCCGTGGGCGAGTCTTCGCTCCCAAGGCGGGGTGGGGTAGCGTGCGGAGGCAGCTCGTGGGAATGGGGCGATGTGGTTGCTGCGGGGTTTGGTGTGCCTGTGCGCTGGAGCGTGTGGTGGAGGTGTGGTGTTCTCAGGGTCGCGTTGACTCCGCTGGGTGACGGCGTGGTTGTGCGGGTGACGCACGATGCACAGCTGTCATGCCCGTGAAGTGCGCGGGGTGCTTTGCGCCGTGGTGGCGTTGCTCGTCTGTGGCATGGAGGCCTCAGTGCCTGTTCGTCATCGTGTCTGGCGGTGGCCTAGAGGGCCACTGCTCTGCCGCGTCGATCCTCTCGACGAGGAGGTTGGCCCAGGCGACTGCCTTGGGCCTTGAGGATCGGGGCAGGTTGTTCTATCGGGGCATCTTCCTGAGGTTCTCGAGTTTCCAGAGCGCCTCGGGATTGGCGGCGGCGGCCTTGGCCATCGACTCGTCTTGGAAGACGAGCTCCGGGCGATAGTCTCCGGCTGCCAGCCGTTCCAGGTACTCGCGCTCTCTATCCGTCTTGGGAAGGATCCAGTCAGCGACGAAGCGCTTGGCGTCCTCCATGAGGGCCTCAAGCGTCGGGTGCTCTATCGACGAGCGGAGCATGGGGTAGAGCTGGTCTGCGAGCTCGGAAAGTCTGTCCGCGAAGCGCTGCTCCCTTCCCTCGAAAGGCTTTGGAAAGCACGCGGAGAGCGAGGCGTAGTACAGGGCCAGCCGGTGGACCCTCTCCTGCTCGCCGGGTTCGAGTGTCTCGTAGACGCCCTTCAGGTTGGAGATGTCGTAGAGGTCGCGGACCTTCACACGGTCGAAGAACGCCTTCACCTTGCCGGCCGCGAGCTCGGCGTCCGCGAGCGTGCGCACCATAGCGCCCGGCCTCACGGGCGTCTCTCGCAACACGGCTGCAGGATGGGAGAGCGGTTCATGTAGATGCAGTCGACCTTGACGTGGCCGACGCCCCAGTCGCCACGGTAGCGCAAGAGGAAGGTACGTCCAGCATGCCCGCCGGGGTGTGCCTCTACCGCATAGCCCTGTGCCTGTGCGACGGCCTCTATGCCGTCCTCGACGTGCGGCCTGTCGGCGAGCATGCCCTTGCGTGAGACGCTGCCGATGTAGGAGACGTCGATGTCGACCGAGAGCCTCGGTACGTCGAGCATGAAGAGGTTGATGGCGGTGTCGCCGTGCAGCGCCAGCTTGCCTTTGAGGGCGGGGTGGCGTTCCATCTCGTCCAGGAGGTCGAGCAGGCGCTCGACCTTGTCCACGGTCCTCGGCTCGAACTCGCCAGTGCTCATGATGTCCACGACAGGACCTCCTCCTCGCTTTCGGGCAGGTACAACCTCCAGCGACGGCTCCAGCCCCTGTTCTCCTGTGATTTCGGATCCAACTTGGATGGGCCGCGCCGAAGTCGCCCTTCGAGCGCTGAGAGCGTCTCGTCGGCTATGCCCCAGTCGCCCCGCTTCGCTTCGAGGAGCCAGCCCGCCCGGGCGACGGCGGCGGCAGGTGCGCTGCCAAGGATCTCGGTCAGGGCTTCTAGGTCGAGGTAGGGAAAGGCCGAGCAGGAGCGCAACGCCTCCTCTGCGCCGCCGGCTCTTTTGGGGTACATCAGGCAATCGATGAGCGTCTGCTCGCGCGTGGTCACCCTGACCGCACCGTAGGACCTCGAGCGCATGGTCTGCACACGCGGATCGCCGCCGGCACCGAAGGGGACGTAGCGGACGCCCCCGTACTCAAATGGCGAGCGCACTGTTGCGGACCTGAACGAGCACTCGAAGCCGACATTGTGCGCGACGCCGTGAGCCACGAGCGCCGAGTGATACGAGACGATCGCCTCGGGGTCGACGGTCTTGGCCACGAGGAACGGGTCGGGCGCCTCGCCGAGGAACTTGCCGGTCTTGGAGACATAGGCGCCCCGGCGCACCCGCTCGACCTCGCCCGACCTGAGGGCGCGTCGCAGAAGCGTCCGCGCGGTCTCCCTCGTGGCGATGGCGTAAAGGTCGCCCGTCGTGAACGCCTGATGCGATGCTATGTACTCTTTGAACTTCATGCAGACGAAGTATAGTGGAAACAGGTACAAATTGTAACCATTTCCATATGATATTAACTGCAAATCTGAGAATCCCATCCAATCCCATCCACCGAGACATGGCGCGGAAGAGCCGGTGCGCGAAGCTCCTGGCGAGCCTAAGGATGTCCACGGGAAGCCTCCTTCCCCTCTGCGGAGGCGAGCATGGCCCTGAGCTGCTCCGCCGAGAAGGTGGGGCCGCCGGCACCAGCGCTCGATGTGGCAGCGGGGGCTGGGGAAGTCGCAGAGCGAGCCGAGGTCCACGTCGAAAGAGTCGGCCACCCTGTCCACGGCTGCCCGCTTGGCCTTTGGGTCGACGTCGGCGTGGATGTCCGGGGTCATCGACGCGCTCGCGTGCCCTAGGCAGCTCGCCGCGGTCCTCACGTCGCGCCCGCCCGCTATCATCATGGTGGCGAGGGTGTGCCTGAGGTCGTGGAACGCGCAGCTAAGGCCGTTCACCCTGCGGAGGGCCGAGAGGTCCTTGCCGAGCCGAGCTGGGTTGCAGGGCAGGCCCCCCGCGTTCCCGGTGTGCAGGGGTCGCCGCGCGCCACTCCCGTCTCGTACGCCACGCGCTCGGTGTCGCGGCGCTTGGCGGAGAGCGTTGTCTCCAGGTGCTTGGTGAGCGCGTATCCGTCGCCGCCCATGTCGCGCATCCAGGAGGACACGCCCTCTGCAGAGAGGCCCGCTAGGCGAACGTTTCGGGTACAGGGGTCGATCTGGCGCGCCCCGGCAGTTGCTACGCCCTCCGCCGCACGCGCAGGACGTCTCCTTTCGGGAAGTTGTTGGGATTCCAGGTGTAGTCGCCGTCTCTCTCGCAGAGCGCGACGTACGGACTGTGCTCGAGCCTTCTGCCACCTTGTGAGAGGGGGACGGGACGCTCGGCGAAGCCCATGACCGGGAGAGCCTTGCGGCCGTTCACCGTTTCCATCCAAACTTCGTCGCCCAGCTCGATCTCGGCCGCGCGCACCTCAACCGCGTTCAGGTACTCGCCAAGCCGTTCGTCCTTAGGCATCGAGGTCGAACGTTCGGGGCATCTCGTCGAAGTCGGATTGGTCCTGCTCGGCGAAAGCAAGTCGTAGGGCTCCTCGCGCCAACAATCTCTCAGCCGTCGATGACGTGGGCGCCGTTGTCGCCCTGGTCGCCTAATTGCTCGACCCGGTCGATTCCCAAGCATAGGCCGCTCCCGAAGAAGTTGCCCATCACCTGGCAGATCCGTGCCCATCCGTAGCAGTCTCCGCTCGGTGGGCGGTAGCCCTGTAGCTCGCAGTACCTGAGCAGTGGTGCGACCGTGTCCTTGCCGCGTTCCAGTGCAGGTAGACGCCGATCTCATGCTCCTTCGTGGTGATGACTGCCCTGTTTCCCATGATTGGCCCCCTAAGCTTGTGGGGCGCCCCTTTGGCGCTCCCCGTGGCCCGGGCGGTGCCGGTGGCACGTGCGGCTGCAAGGGAGGAAGCAAAATCCGGAGGGCATGAGTTTTCGCTCATAGACATGATGTGCGTAGCGAAGAGTTTTGTCGGCCTACTTGGACTCCGAAGTACGAATAGGTGGAGATAAAAGCGAGGCCAATACCTCATCGGGTTTAAACTATGGATGACTAACGACAAGGAGACGCCGATGCAGCAGCCCCTCGCGACGAACGACGTCGCCCTCTTCTCCACCTCCAAGGAGAACCAGTACTTCGACCGCAAAAGCGCCCGCAAGGATGACAAGGAGATTGCCAAGCATATTAGCCCTAGTTCTTTCTGATTGTAGAACTACCGCCTGATCAAACCAAAGAAAATCGAGAAAATCGCAGGTCGAGGCCCCAAGGGGCCTCTCTTGTGCTATATTATATGTAGTGCTACTTACTACTTCCTGTGTGGCACGGGAGGCGACCGGGATGCCGTTCATAAAGGTGCAGAAGCTGGTCAGGGACGAGTCCGGCGCAATCAGGAGCGGGTCCGCCGCCGTGGTCGACACGTCGTACGTGCGCGGCGCCAAGTACCACTCGGCGCAGGCGGTGCGCGAGAGGCTGGGCAAGGTCGTCTGGCTCGCGGACGACAGGCGCTCGGGCGTGTTCGCGTCACCGACGCGCGGCCTGGTGGAGTACGACGCGGACGCCGACGGATTCGCGCCGGTGGCCAAGGGCGACGAGCGGCTGGCGAACACGGGCGCGTTCCCCGAGCCGCCGCGGCACCTGGAGCTCGGCCCCGAGCACCTGCTGCTGTCGTTCCTGGGCGCCGATGGGGTCGCGGGGTGCCTCAGGGAGGCGCTCCCCGACGACCGGTCCTACCAGCGCGCCCTCGCCCACGTCACGCACGGCGTGGTGCGGGACGGGAGCCGCGAGACCTGCGACAACATGGTGGCCAGGTCCTTCGCGGCTCTGGCGCTGCCGGGCGTGCCGCCCGCGTCGCTGAGATCGGACACGGCGTTCTTCTCGGCGATGGGCGCCGACGGGGCGAAGGTCGCGTTCTTCAGGGCGTTCGCCAGGCTCATGAGGAGGACGAAGCCCGGCTTCGGCCGCGCATGCTACGTGGACTCCACCCCGCTCCCGAACGACGCGGTCGACAACCCGCTCAACGCCCTCTGCAGCCACGGGCTGAGGGGCGCGGCGGTCCAGATGCGCCTCGCGCTCGTGCTCGACGAGACGACGGGGCTGCCCGTCTGGTACGAGGTCGTGCCCGGCAACGTACTTGACCTCTCGACCATAAAGACCGTGATGGGCGACGTCCTCGCCACGCTCGGCATCGAGGTCGTAACCGCGGTCCTCGACGCGGGCTACGCGTCGCGCGAGCTGCTCGAGGCCTTCTCCGAGGGCGAGAGGGACGTGCTGGTCAGGATGCCGGCGAGGAGGGGGTACCCGTACCGCGAGCTCTGGCGGGGCGTCCGCTCTCTGATCGGCAAGGGCAAGTACGCGATCACGCGCTCCGGCCACCTCTACTTCGCCAGGAGGCGCGACGTCGAGGTGCAGGGCGTGAGGCTGCACTGCTACGTCTACGTGGACCAGACCAACGCCACGCCGCGCTTCGCCAGGTGGCTGGACAAGAACCAGGAGAGGTTCGACGGGATGTCGCTCGCCGAGAAGGACTGGGAGACCGTGCGGCAGGGCTACTTCGTGCTGATGTCCACCAAGGTCGCGACGCCCCGCGAGATCCTGGACGAGTACTTCTGCCGCACCGAGATCGAGGGCGTCTTCAAGACCAGCAAGGACTACCTGGGCCTGCTGCCGCTGCGCAAGTGGAGCGACCTCACCGTGCGCGGCAAGATCCTCGCCGACATCATCGGCACCATCGTGGTGCTCAGGATGCGCAAGGCGCTCGCCGGGGCCGACGTCTCCCTCACCGAGGTATGGGGCAAGGCCAGGTCGCTGTCCTGCTACACCAACGCCGACGGCAGGGTCGTGGTCGAGACGCCGTCGAGGCAGGTCCGCGAGTACTACAAGGCGCTCGGGGTGAAGGTGCCCTCGTCAATCGACGTCAGGGAATTCGACCGTGACGTCCTCGGCCTGGAGCTGTAGTTCTACAATTAGCGTCATCTAGGGATTAGTGCCTTCGCTAACGCGTCGGGCGGTAAGCTCGTCATCGGCATCGAGGACGGCGGCGATGTCACGGGCTTCAGGAGAAACGGCGCCCGTAACATCGAGGACTTCGAGAGGGCGCCGCTCGCTACCTGCTCCCCGAGCCCCATCGTCCGCGCTGAGCGCGTCTCCGTGACCAATTCGGCCGGCGAGGATGACATAGTGCTCGTCTTGGATATCGAGGCGTCCTCGAGCCACGTCATCTCCCGCTTGAGCGACGGCGAGGTCTTCCTGCGGCAGAATGACAGGAGCGTTAGGCTGACCCGCGGGCAGGTCCTGGCCCTCGAGTACGATAAGGGCCAGCGCGCCTTCGAGGACGAGCTCATCGAGGACTCCTCGATAGAGGACGTCGACCACGAGGTCCTGGATAGGTATAAGGGAGTCCTTGGGACCGACCTTCCTGACGAGCAGGTGCTTAGATCCAGGCGCTTCATGCGTGACGGCAAGCTGACCGTCGCGGGCGCACTGCTCTTCGCAGGTGATCCGTCTGCGATGATGCCCCAGGCGCGCGTGCGCGTGCTGCGCTACGATGGCACGAGGGCCGAGACCGGTAAGCGCCTCAACATCACGAAAGAGCGCGTGTTCTGCGGCCCTCTTCCCAGGGTCATCGAGGGCGCATACTCGCTTATCTCCGGTATGCTGCGAGAGTTCCAGTTCCTGGCGTCGGATGGCAAGTTCCGAACGGTCCCAGAGTACCCTGAGTTTGCGTGGTTCGAGGGACTTGTGAACGCCGTCACGCACCGCGACTACGCCTATCGCGGCGACTACGTGCGCGTCTCGGTCTTCGACGACCGCTTGGAGATTGTGAGTCCGGGTGCGCTGCCCAACATCGTGACGCTCGACAACATGATGACGACGCGCTACTCGCGTAATCCGCGCATAGCGCGTACCCTCGTCGAGTTCGGCTGGGTTCGCGAGCTCAACGAGGGCGTGCCGCGCATCTACAGCGAGATGCAGAGCATGCTGCTCAAGGACCCCACCTACTCCGAGCCGGGCGGCGCCAAGGTCCAGCTGACGCTCGAGAACAACATCGTCGCGCGTACGGTGAGACGCCATGAGGCCCTCGAGGACAGGTTGACCGAAGGGGTGGTCTCCGCGCTCGACGAGTACGAGCTGGCGGCGGTGCGCCTCGCCTTCACGAATGGGAGGGTCACGGCCAAGGAGCTCGCTGAGCGCATTGGCCGCAGCCAGAGAACCGCCACCAGAGTGCTTAAGGGCATTGCCGGGCCAGGGGGCCTGCTTGAGTGGCACGGCTCCTCGATCAACGACCCCCGTCAGTTCTATGCGCTGAGGTAGAATCCTCCTTGTCGTACCTTGTCGTACCTTGTCGTACCTTGTCGAAGCCCCGAAGAACCCCTTGGACCTATTCCGCGTAGCCCGTTTACCTGCGACGCGTTGAGTCTGGTTCCGAAGTTTCCATCGCGTCATAGCCCTGCCGTGACTTTGTCGGAGCATGTCGGACCTGTCGGACCTCGCGGTCCCGTCTCTACAGCAGTCCGTCCAGCTTCTCCATCTGGGTACGCTTGCCGTCCTCAAGGTTGTCGGTGTAGGCGCGTAGTGTCATGGCGGGGTCCGCGTGGCCGAGCAGCGTCGAGACCGTCTGTCACATTCTGTGACCTTAGAGCTAGAGATCTCATTTTTCTATTTGTCAAGCGCGGCGACAATCGAGCCAACGACGGCGGAGTCCTCAAGCTTGGCGACCGCGAAGCTCTTCTTGCCTGCGTCCTTCAGCGACGCCCCCACCAGGTAGCCCTCGATACCGTCTAGGATGAGGAAGCGGTCATGGAACGAGGCCGTGTGCCTGATCTCGAGCGTGGAGTACTGCGCGTTGAAGGTCTCGATGTCACACTTGGTGAGGCTGGTCTTTGGGTGCGTCCACACGGTGACGGAGACGCCTTGCCTCTTCTTAGCGAGGATGTTGAGCGTCCCCGTGTCCACGTAGCCGTCAATCAGGACGATTTTTCGCTTGGCTCTCTGCACGAGGGAAACCAGCAGCTCGAACGTATCGTAGACCTGTCCCTCGAAGAAGACCTTCTGGCTCGGCGCCTCGTGAGTCTCCATGTAGTCGAAGACACGCTCGAAGCGCTCGTCGGTGCTCTTCTGATATTTGAGCTGTCTGAGCTCAACCGTGCGGATCTGCTCGAACATATGGGCGTTGTCTGCGATGAAGTGTCGCATCTCTACGAAGGCGCGCATGATGCGGACGCTTGCATCAATTGCGACCCTGCTGCGGAGCACGCCCGAGAGCATCGCCACGCCTTGCTCGGTGTACACATAAGGCATGTAACGGCGACCGCCAGCTGCGAATTTCTGCAGGTCATCGCTTGAGATGCCAATTTGGCACCTCAAGTTTTCGTACTCGTCGTCAGTGAGCCTGAAGCGGAAGTCCTCGGGAAAGCGGTCCTCATTGCGCTTGGCGGCGCGGTTGAGGGCGCCGGTCTCGACCTCGTACAGTTCGGCAAGGTCGCTGTCGAGCATTACCTGCTGGCCTCGCACGGTGTAGATCATGTCCCTGATCTGCGCATCGTTGGAGGCGATGATTGCAGATTCATTCCTAGCGGGTTCTTTTGCAGCCATGGCCGTAGTCTTCCTCCTCGAACCGATGATGCAATTCTATCAAGCGTGCTCACATCCAGCGCGAGACGGCGCGGAAGAGCCAGCGCACGAAGCGCCAGACGAGCCTAAAGATGCTCATGGCCTGCCTCCTTCTCCTCTGCGGCTGCGAGCATGGCCTTGAGCTGGTCCACCGAGAACGTGAGCGCGACGGCGCTTACGCTCGGCGCCGTGGCGGGACTCGGGAAGTCGTAGAGCGAGTCGAGGTCCACGTCGAACGAGTCCGCCACCTTGTCCACAGCCGCACGCTTCGCATCCGGGTCCACGTCGGCATAGATGTCCAGGGTCATGGATACGCTGGCATGCCCCAGGTAGCTCGCAACGGTCCTCACGTCGCAGCCGCCAGCAATCATCATGGTGGCGAAGGTGTGCCTGAGGTCGTGGAAGGTGCAGGAAAAGCCGTTCATCTTGCAGAAGGCGGCGAAGTCCTTCCCGAGCTGCGTGGGGTTGTAGGGCCGACTCTTCTCCTCCTGCGTTCCCAGAATATACGGATCGCCCAGCGACACGCCCATCTCGCGCGCCACGCGCTCCGCGTCGCGGCGCCTAGCGGAGAGCATCGTGTTCAGGTGCTTGGTGAGGGGGATTGTCCTGACGGAGCTCCCGGTCTTGGGCTCCTTCACGTAGAAGCCGCCCGGACCGTTTCCCAGGGCGTGGCTCACGGTTATGGTGCCGTCGTCGGAGAGGTCCGACCACCTGAGGGCGCAGACCTCGCCGCGCCTCATGCCCGTGGTGAGGGCGATCTCCACCGTGAAGCCCAAGGGCTGCGGCTCCGCCTGCATGGCGAGGCGCAGCATCCGCGTGCGCTCCTCACGCGAGAGGGCGTTGATGGGCGTCTTCACGCGCTTGGGCGGCTTGCAGAAGTCGTAGGGGTTCTTCGCTATGAGGTCCTGCGCCACGGCCCACTTGAGCGCCTGCTTGAATAGGCGGAAGGCCTTAGAGCAGCTCTTGGGCGCGTAGCTGTCCGCGCTCATGTCGTGCATCCATCCGGAGACGTCCGGAGTACTTCTTCTTTTCCTAAGGACCAAAGCCAACGAAAGCAACGGTATCGGTAACAGCATCGCGGGTAACTTGCCGCTACTTTTTGCACTTCGTGTTTGCGAGGTAGACCATTGCGACGCTGTCAACTGCGATGACGGCGGTTGACACGCACACGAGCACTATGGGGGCCGCCCCTCCCAGCAGTGCCAAGACGAAAATGACGAGCGTGGCCACGAGCATCCCTCCACCCATGACCCGGAGCAGCTTCCGCTCGTTCACCGTCTCCTTCTCCGCCTCGGTGGCAGTGTTGTAGCCCGCGATAAGGTTTGCTCCGTGACCGGACAGAAAGGCGACGGTCATGGCGGCGCACACCGCGAATATGACCCACAGCACGATACGTGCGAGCATATCATCCACCTCGAACTCTTCTGCTTGACCCTTTGTCCATTGTATGCCTGACAGCTCCTTGTCCCTTATTCGAGCAGCATGCCCTTCTCCATGCGTCCTCGTTGGCTATCGTCGGCACCCTGCGGGCGGCTTTGGCCGCTGTGGCTCGACTGTCCCTCATGTTGCCCCACGTCATATCCTGCGCAAAACCTGCGCCTTGAGCTGCCTCTCGGCGTCCCAGACCTCGGCCCTGTCCTCGTAGACGCTCCTCTCAAACCTCGGCATCCATGCGCTCGTTCTTCGCGGTGCCGGGGAATATCGCTCGGGCGTTCCTCATCTGTCACCTGCAAGCCCTGTGGGGTGAATGACCATGGGCTCCTCGTCCACTTGCTAGAGGGCATAGCATGTCCCTGAGGAGGCAGAGGAGCAGGCAACTCGTGAAAGGGCATCGAGGCGTGCTTGAGCGGTCGGTCCTTGTCCTTCTGGCCGTTATGGCAGACGTAATCCCTAGATGACGCTAATTGTAGAACTACAGCTCCAGGCCGAGGACGTCACGGTCGAATTCCCTGACGTCGATTGACGAGGGCACCTTCACCCCGAGCGCCTTGTAGTACTCGCGGACCTGCCTCGACGGCGTCTCGACCACGACCCTGCCGTCGGCGTTGGTGTAGCAGGACAGCGACCTGGCCTTGCCCCATACCTCGGTGAGGGAGACGTCGGCCCCGGCGAGCGCCTTGCGCATCCTGAGCACCACGATGGTGCCGATGATGTCGGCGAGGATCTTGCCGCGCACGGTGAGGTCGCTCCACTTGCGCAGCGGCAGCAGGCCCAGGTAGTCCTTGCTGGTCTTGAAGACGCCCTCGATCTCGGTGCGGCAGAAGTACTCGTCCAGGATCTCGCGGGGCGTCGCGACCTTGGTGGACATCAGCACGAAGTAGCCCTGCCGCACGGTCTCCCAGTCCTTCTCGGCGAGCGACATCCCGTCGAACCTCTCCTGGTTCTTGTCCAGCCACCTGGCGAAGCGCGGCGTGGCGTTGGTCTGGTCCACGTAGACGTAGCAGTGCAGCCTCACGCCCTGCACCTCGACGTCGCGCCTCCTGGCGAAGTAGAGGTGGCCGGAGCGCGTGATCGCGTACTTGCCCTTGCCGATCAGAGAGCGGACGCCCCGCCAGAGCTCGCGGTACGGGTACCCCCTCCTCGCCGGCATCCTGACCAGCACGTCCCTCTCGCCCTCGGAGAAGGCCTCGAGCAGCTCGCGCGACGCGTAGCCCGCGTCGAGGACCGCGGTTACGACCTCGATGCCGAGCGTGGCGAGGACGTCGCCCATCACGGTCTTTATGGTCGAGAGGTCAAGTACGTTGCCGGGCACGACCTCGTACCAGACGGGCAGCCCCGTCGTCTCGTCGAGCACGAGCGCGAGGCGCATCTGGACCGCCGCGCCCCTCAGCCCGTGGCTGCAGAGGGCGTTGAGCGGGTTGTCGACCGCGTCGTTCGGGAGCGGGGTGGAGTCCACGTAGCATGCGCGGCCGAAGCCGGGCTTCGTCCTCCTCATGAGCCTGGCGAACGCCCTGAAGAACGCGACCTTCGCCCCGTCGGCGCCCATCGCCGAGAAGAACGCCGTGTCCGATCTCAGCGACGCGGGCGGCACGCCCGGCAGCGCCAGAGCCGCGAAGGACCTGGCCACCATGTTGTCGCAGGTCTCGCGGCTCCCGTCCCGCACCACGCCGTGCGTGACGTGGGCGAGGGCGCGCTGGTAGGACCGGTCGTCGGGGAGCGCCTCCCTGAGGCACCCCGCGACCCCATCGGCGCCCAGGAACGACAGCAGCAGGTGCTCGGGGCCGAGCTCCAGGTGCCGCGGCGGCTCGGGGAACGCGCCCGTGTTCGCCAGCCGCTCGTCGCCCTTGGCCACCGGCGCGAATCCGTCGGCGTCCGCGTCGTACTCCACCAGGCCGCGCGTCGGTGACGCGAACACGCCCGAGCGCCTGTCGTCCGCGAGCCAGACGACCTTGCCCAGCCTCTCGCGCACCGCCTGCGCCGAGTGGTACTTGGCGCCGCGCACGTACGACGTGTCGACCACGGCGGCGGACCCGCTCCTGATTGCGCCGGACTCGTCCCTGACCAGCTTCTGCACCTTTATGAACGGCATCCCGGTCGCCTCCCGTGCCACACAGGAAGTAGTAAGTAGCACTACATATAATATAGCACAAGAGAGGCCCCTTGGGGCCTCGACCTGCGATTTTCTCGATTTTCTTTGGTTTGATCAGGCGGTAGTTCTACAATCAGAAAGAACTAGGGGTAATTGTCCACGGAGTGCGGAAGCGGCGCAGAGAGAAGGGCACTCCGAAGCATATGGAGTGATGCGATCAGAAAAGAGCGGCTCGGCTCACCAGGAGCCGGGTCGCCTGCGTACGGGAGCGCGTTTTCTGAGTCTACGTCAGCCGATGGAGACCGACCCACTGCTAGAGGGTGACGGGGGCACCGCCCACCAGCACGTTCGTGCCGTCGAGCTCCGTCTTCACCGTATCGTGATAGGCAGGAATCCAGGCGAAGTGGCCGATGTAGCGCTGGGGCTGGCCGAACTTGTCGTGGTAGCGCCCAGTCTCGTCCTTGATGTGGTCGAAGCAGGTGATATGTACGTCTGTGGCACCGAGCTCCTTGAGTCTCCTATAGTTTGCCAAGGTATGGACATCTGCCGTCACGATCGGGTCGTCAGCAGACTGCACGAACCAGAGGGGCGTCTTGGCAATCGACTTCATCTCGCCGTCTGTTGCCAGGGATGCGACCCAGGGAGCACAGATGGGGACGCCTGCGGCAAAGAATCCCGGATAGTCTGCCACCAGTCTCATGGTCATAAATCCGCCGTTCGAGAGTCCACCCACATAGATGCGCTTGTGGTCGATGTCGGGACGCGCTTCTATGAACTCATCGATCAGGGTCTTCAGCGCCTTCGTGTAGATGGACTTGTTGTCATCTGCAATTTCTCCCGAGCCTGAGTCCATCCAGTAGGTCGGGCTCGAAAGGGCAAGGATGTAGGCGGCACCGCCGAGCTTTTCCTGGATGTCGGGGGAGGAGAGCGCCGTCACGCGGTTGCCCATAACGGTACGGTAGGGCTCCTGCCCTTCTCCTGCACCATGGAGCCAGACGAGGAGCGGCACCTTCTCGACAGGAGGAAGCGGCGTGAACGGACGGGTTGCACGTGCAGCATTGACTGTAATGAGATCGGGCGTGAAGAAACCGTAGTTCATATCAATATCATCGAAGATGCCGGAGCCCGTGAGGTCCCAGCCAGTAAGATCGGGGCAGACGTCTCCTGTGTCGATATCGAATACCATGCCTGTGAGCGGGGCCTCTCCGGGCCCTTCACTCGGGATCTCCTTCGTCTGCGTGATGCGGAAGCTCATCGGGCGGATGTAGCCACGGGTGAGCGCTCCATCGATCCTTTTCGTGAGGAGCTCTTCGGGGAGCTTGAGCGCGATAGAGGAGCCCTCGGTCTGCGGGTTGCCTTCGCCGTCAGAGGCATAGGCAGCAAGCACGGGAATGTAGCCCTTCGAAGGGAAGGCGCACTCGTCCGTATGGTGCTCCTTTGCGAGCACGACCTCGCTGGTCTTTGCATCATTGCGCTCCACATAGACGCTGAAGCCCTGCCTGTCTACGAATTTTGTGTGTACCTTCTCGGGGAGCTCGAGGATGAGCTTCGAGACATAGGGCCCCATATCGGTGGCCGAGGTGAAGGTCTTGTATCCAGCCATGCATATTCCCTTTCCTGTGCGGCAGGGCCAGCTTCCCACTGGCCCTGCGCTGTGTGTCCGTTGCGTGTTCTACCCAGATAGGTCAGCTATATGGCAGCGGACCTGTCGAAAGGCCACCTGCCTGCCAGAGCGTTTGCTCTGCCTCACTGTGTCTGCCATCTGGGGCGTATAGGTCTCATGTCCGTACCACTCATGAATTGCGTTTGTGGTCCAGAGACCAGCTGCATGGCCTGCAGCGAAGGCGGCTCCTGCGGCAGAGAGCTCGGCGAGCTTTGAGGCCTCGACCGAGGTGTCTGCCATGTCTGCCTGAAACTGCATGAGGTAAGCATTCTTTGTGACGCCGCCATCTGCCCTGAGCGTCTCGAGGGCAAGACCCGTATCTGCCCTGAGTGCATTGAGCGCATCTGCTATCTGGTGGGGGATGCACCCGGTACAGGCCTTTACGATCTCTGCCCTGCCGGTGAGCGTCGTGACGCCTGCGAGCATGTCCGTGGCGCCACTATCCCACCGGGGTGCACCGAGGCTCGTGAAGGCCGGCACGAAGTAGCTCCGATCATTCTGGTTTGCCTCTTGGATCAGGCCTTCAAGCTCGTCCGGGCTTTCGATCAGATGCACCACATTCTTCAGCCAGGTGACGACGGCCCCGTGTATCTGAGGTTTCCTTCGAGCACATAGGGGAGCCCGCCTTCGAGGCTCCAGGCAATGCTCGAGACAAGGCCATGCGTGCTCCGGATGGGGGCATCCCCTGCCATGAGCATGACAGAGGAGCCGGTACCGTAGGTTGCCTTCACCTGTCTTGGCGCGAGGCAGTCCCGAGCAGCAAGCGCTGCCCGGGAGTCTCCGAGCATCGCATGGAGCGGGATGGGATTTGAGAGCGTGCCGTTGAAGCCCGAGACGCCGAAGAGGGCATCGGATGGCAATGCCTTAGGGAGTGCTGCACGGGGAATGCCGAAGAGATATGACCGGTGCACTCACTGTTGGGTGTGCCGGTCACTTAACGTGCGAATAATCAATAGTTGTTCAAGCAGCATAGGATAATGCTGGAGATTGATATGCGTTCGGGGGGCTCCTCATGCTGATGGGCAACGCGAAGCGCGGAGCCTTCTACTGTATTCTTGACCTTATCGTCTCTCTCGGTTCCGCACCCCAGGTCATGTTTTTGCTCATTGTATTGAGTAAAATCACGCATCATCATTCGAAATAAAAGGAGGCGAGCCTTGATGTTCCAGCGCAAGATCGTGGAGATCATCGCCGCGAGGATGTGGGAGGACGATAACCGCCCCATCCAGGTCGTGGCCGGTCCCCGCCAAACTGGCAAGTCAACGGCAATCGCACAGGCGCTCGAGAAAGTGGACAAGCCCGCCCACTCGGCGAGCGCTGATGACGTCATCGCCCCCGACGTGTAATGGCTGCGGACGGAGTGGCAACAGGCGCGCAACTTGCAGCGCGATTCGGACAGACCAGCCATTCTCGTGCTCGACGAGGCGCAGAAGGTGCGCGGATGGCCCAACGCGGTGAAGGGGCTCCGGGACGCCGATCAACGCGAGGGGCGCCCTCTGAAGGTCGTGCTGTCTGGCTCGTCGAGCCTGCTCCTGCGCAAGGGGCTTGAGGACTCGCTGAAGGGACGCTTCGAGGTGCTGCGCTCCACGCATTGGGGCCTTGCCGAGTGCCGGGAGGCGTTCGGGTTCACACTCGACGACTTCCTGTTCTTTGGGGGCTTCCCAGGCGCTGTGCGCCTTGTGGTCGACGAGAGGCGCTGGCGGGCGTACATGCGGGACTCGATCATCGAGCCCACGATATCCAACGACGTGCTCGAGCAGGAGGACGTGCGCGAGCCGGCGCTCTTGCGTGCGCTTTTCGACCTGGGGGCGCGCTTCTCTGGCCAGGAGCTCTCCTACAACAAGATGCTCGGCTAGCTGCAGGATGCTGGCAACACGACGACGCTGGCGCACTACCTGACCCTGCTCGACAAGGCGGGCGTGCTCTGCGGCCTCAAGAAGTACCACCCGAAGGCCATCGAGCGCAGGAAGTCCTCGCCGAGGCTCATGGTCTACGACACGGCGCTCATGACGGTGGTTTCCGGCCGCTCGAGGGAGCTGCTGTTGGGCGACTCGGAGCTTCGCGGCCACCTCGTAAAGAGCGCCGTCGGGGCCCGCCTGCTCGCCCTGGGGCTGGACCTTGGCTTCGACGTGCAGTGGTGGCGCGAGGGGAACGACGAGGTCGATTTTGTGCTCTAGTGGCCGCGACGCTTCTCGCGACGCTTTGCCTGCCTGAGGTCGAACTTGCGCCGTTCCTCGGCCTCGCGGAGCTCCTTTCCCTCACGCTTGCGCTCGGACTTGGCCGCCTCAAGCTGCGCCTGCAGCGCCCGTTGCGACCTGGTGCCGATGCCAGACTCCCTTACCTGCCTGCGGGCTGCCCGCTGCCTGCGCTTCGGGCTCTCGGCGACGCGGTGTGCCTCCGCCGCCACGGGTGGGCTGAACTTGAGGTCGCAGAAGTGCCCGAGCACGAAGTCTAGGACCTCGGGGTCGCTCGGCTCGGCGCCGAAGGTGACCTTCGCCACCGCGAGCTCGCCGCCCTCGACCCTCTCGAAGATGCCCACCCAGAAGGGTGCGTCGAACAGCACGGTCAGCGTGATGCTGGATTGCTCCATGGTCTTCCTCCTTTGTATGTCGTCTCGCGAAGAACGGACAACCCAAGGAGGGAGGGTTACTTACCCCGCAGATGCGGGACGGCCGGGCTACCTACCGGCTCTGGCGCGTACGAGCGCGCGTTGCGTTTCTATCTTCACGGGCGCCAGTCGCTCGGACAGACGCCAATGCACATTATAGCAGGCGGCGGGCCCTATCGGCGCGTCTCCCCGAGGTTCTCGAGCTTCCAGAGCGCCTCCGGGTTGGCTGCGGCGGCGCCTGCCATCGCATCGTCTCGGAAGACGAGCTCCGGGCGGTGGCCCCCGTAGTTCCGCAGTATAGAGGATGCTTCGTGAGTTCGTGTGGGTGGTTGCGTCACCGCCCCGGTGGCGTGGGCCTCAGGTCCGAGCGCGCTGACGTCACGGGGCCATGGGGCCGTCGTCGTGGGACCCGTGGCCCCGCTCGGTCGCGCGAGCAGCCGTGAGGGCAAAAGAGTGTACACAGATCGACGAAAATGACCTCTCGGAGCCGTTTTGGGGCATTTGTGTACACTGTTGCGCCGTTGTGGGCAGACGTGGGAACGCAGGAGTGTACACAGATCGGCGAAAACGGCCTCTCGGTGTCGTTCTGGGGCACTTGTGTACACTGTTGCGACGCGAGGGTCGTGCGAGTTGCGACGCGAGCCGCGTCGGGTGGCACGAGTGCCCCAACCACCATGGCGTGCTGGCGACGCCCCCTCGGTGGCCACCTCTCGCCTGGTAGGGAAAACAGATCCTGCGCCAGTGGCGCCGCCGCTAGCTTGGTGTCTTCGTCGAGACGTCAACCCACACAAACCCCCGAAGAGCTTTTTTCAGTGTAAACGGACTATAGGGGGTGATGGGCATGCAGGCTATCGTCGATCTGGCGCAGGAGAGCGGCGGGATGATGACGACGACGCAAGTGGTTGAGGCCGGCATCCCTCGCGCGCGTATCTCGGACATGGTGAAGGCCGGAAAGCTCGAGCGCGTCCAGCGCGGCGTGTACTACCTGGCGGATACCTGGAAGGACGAGTTCCTCGCGGCGCAGCTCCGCTTCTTTAAGGGAGCTTTATCAGACGGGACGGTGCTCTTTCTGCACGGCTACACCGACCGCACCCCCCTCCAACTCACCATAACCTTCCCGTGCTCGTGTCGGGCCACCAAGGCGCGGGAGGCGGGCATCGAGGTGAGGACATGCGCCGATGGGGTCCTCGACCTGGGACGTACAAGCGTCAGGACGAGCTATGGCAACGAGGTGCGGGCGTACGACCTGAAGCGGACGCTCTGCGATGTCGTCTGCGGCCAGCGCATCGTGGACGTGCAGGTGGTCAGCCCGGCCATGAGGCAATACGCTCGCAGCGGCAGCAAGGATGTCCAGAGGCTGCTTGGCTACGCCCATGCGCTCGAAGTGAAGAAGAAGATCTGAAGCGATCTGGAGGTGCTGCTGTGAGGACAAAGAACGCGATACAGCTCAAGGCTATCATCCGCAACCGGGCGAAGGTCGAGGGCGTCCTTTCGCAGCTGGTGATGCAGAGCTACCTGTTCGAGAGGCTGCTGGAACGCATCTCCCTCTCGACGTGGCGAGACAACATCGTCATCAAGGGTGGAGTGCTCATCAGCTCGCTTGTCGGCGTGGGCAAGCGCAGCACGAAGGACCTGGGCACCACCGTGCGCGGCTTCCCGCTCTCTCCTGAGAACGTCGAAAAGACGTTCCGGGAGATCGTGGACGTGAAGGCTGACAATGACTTCTCTCTTTCGAGTTCGTGCGCACTGAGGACATACGCGAGACCGACGACTACCCTGGCATCAGGGTCCACCTGCTGGCGAACTACGAGAAGATGAGCTCGCTGGTGACCGTGGACGTGACCACGGGCGACAAGATCACGCCAGAGTCAGTCGAGTACAGCTACCCGCTGCTGTTCGACGACCGCAGCATCGCCATCATGTCGTACCTGCTCGCCACTACGCTTGCCGAGAAGCTCGAGATCGCCATCAGCAGGAGCGTGGCCAACACACGGCCGCGCGACTACTATGACCTGCACACGCTGTGGCTCACAAGGAGGGACGAAGCCAAACCCGACGTACTGAGGGATGCCGTGGCGGCCGCTGCGGAGAGGCGCGGGTCGCACGCAGCAATGGGCAACTACCGTGAGGTGATGGCCCAGGTGGCCTCCGATGACGGGACGCTCGGCCTCTGGGCTGCTTACGCCCGCAGGTATCCGTACGTTGGCGACATGACGCTCGGGGAGGCGTGTGGGACGGTCGTGCGACGGTGGTCGAGCGGGAGGAGCGCGACGCGGGCGGCGCGTCCTCGTGCCGCGCGACCGTAAGGGGTCAGTCAGGAAGCTGCTCGATACCCTAGGTGTGCCACTCGAGGCGAGGTTCCCCATCCCCGCCCCGGCGCATACCTAATGATGAGGGAAGCTGTGTATAACAAAGAGAACAACGAAGAGAGGTGGCCTGCTGCTCGCGAAGGAGCCGTCCCAGCTTATACTGCCACTCGGCCCCGATCGTACCAATACGGTACGCTCGATGCCGTCTGGCAGTGCATGGCGCACTGCCCAGTACGTTCACCGGCGAGTGGCAGTGTGAGTGGCACTGCCACTCGGCCATGAGCGTTCCGTTCGCACTGCCACTCGACCCCGATCGTACCAATACGGTACGCTCGGTGCCGCTTGGCAGTGAGTACTACACTGCCACTTGCCCCTGAGCGTTCCACCTCGTACGTTCACCACCGAGTGGCAGTGTGAGTAGCACTGCCACTCGGCCCCAAGCGTTCCGTCCGCATTGTCAAATACCCCTGGAGGTCCTTCACGACGATCGCAAGCAAGCGACGGTATCTTGGCAGCGTTGGCTTGCCCTGCATATCCCCATGGCCTGGCTCGGAGCCAGCCTGCCCTCTGCATTTGCTATACCTATGGAGAAAACCTCTGTTAGGCCACCGTCGGCATGACGATAGCTCGCGTCTTTGCCTCGATATCTTCAGCAGGCTAACGCGTCGAAGAAAGACGTGGAGATGCCTGGCATGATGTCGCAAGAGGGGGTGCCGACTTGGGTGCCGACTGTGTCGGCCTCGACGTAGTTCATGTTGTAGAGCGTGACCGTGAACCAGTTCTCTCCCGTCTCGAGCCTAGGCATGAACTCCGGTCTGTAGGCGTCCTCGGAGGCGGTGGCCGTGCAGATCTCGCGAAGCCCGGAGCCTCGGCGCTCCATGAGGCTCATGCGGTTGAAGACATCGGCGATGATGGGGTTGCGTCGCTCGCTTCTCACGCGGTTTTTTATGATGTCGTCGGACAGGGGTGCGCCAATCTTCCCGCCGAGTGAGCGCACCTTCATGCAATCGTTGTACATGTCCACGTGCACCTCGCTGCCGAGTTCGAGGTACGAGCGGTGGATGAGTGCGTTCACGAGTGTCTCCTCAACTGCTCTCTCGCTGTGGCTACGCCGCTCAATTCTGCTGTTGGGGGTCTTTTCCCACGACTCGGCCGTGTGGCGCTTGACGAATGCCTGGGTCTCGCGGAGCAGGGCGAGCAGGCTGCCCTCGTACTCCGCCGTGTCCGCGAAGTCGTTCTCGTGCTCGCCGGTGAAGCGCGTGCAGAACACGCGTGAGCACCGCACGAGCAGCTGCTCGCAGACCAGCCGCTCGTGAGCGTGTCGTCCTCGATCACGAGGCCAAACGACTTGAGATCAACATCGTCTAACTCGCTGCGCATGCGATTGACATAGGTCGACTTCAAAACGGTGAAGGCCGCCCTACCCGTCGGTATGCCCGAATCGAGCCCGTCCCAGGTGCGGTTCGCGCCCCTCAAGATCAGCTCGTTGAGGATTTCGGGCGGAGCTATGACGCTCTGGTTGCCCACGCGCACTCTGCCTGACGCCGCGTCGCATTCTGCGCGGGTGAAGGTATGGGCTTCTCGCCATGTTCTTCATCTTCACTATGGAATGCGAGAACGGCATGTGCATTAAAATGGAGCAGGAGTACAGGGCGCTAAAGCGTGTATGCGAGTGTCTGCGCCTTTTGGAGCCGTGTTGCCCATCGAAGCTATAGAGGGGCATATTCGCGTGCGGCACGAATGGATGGAGGCATCGGACCCGTTCTACGACTACCGAGACACGGGTGGCTTCAGGCGGATCTACGAGGTTCACCGCAGGAGCATTTACTCTGCGATGAGGGAGAGGTTCACGTTCTCTTTGACGATCCGATTAGCTCCGATACGGCCGCAGAGAAGTCGCAGGACATGGTCGAGGCGGGCGTCACCATGTACGCATGGGAGTGCCGAATGAAGTGGTGCGGCTAGGGCGAGGGCGCACGAGCCTATAAGTACGATGAGTTCTGACGCCTGACCCTTATTGACAGCCTCGGGGCCATTTGGGTGAAATAGTGACAAAACACCTTCTTTACCTGGCCCTTCTTATTAACAGCCTTATTGACTCCATTGTCAGTGAGAGTGTCGGATGGCCTTGTAGACGCGCCCCTTGCGGCCGCCTGTCTTCTCAAGCAGCCCCTCTTCGACCATGGAGTTGAGTAACCTTCTGGCTGTGTAGTCCTTCTCGCCAACAAGCTCGGATGTGGCGGCGGTGGTGATCCCGTTATGCCCGCGTGCGTAGCGAAGTATGGCGGTCCTCGCGTCCCCTTGTCTGCGGGCATCGACGGTTGCCGGCGTATTCCCTGCGGCAATGCCCTCCGAGCGCATGAAGGAGACATGCACACCGTGCCTAGACTGGGTAACCGAGAAGGGCACGTTCGCCTCGTCGCAGGCGGCCTTGATGCGCTGCAGTCCGGTTCCGTAGATCTCGATGTCGCCGGAACGGTAGAGCGTCGTGGCAATGAGTCTGTTCCTAGGCTTGGAAGTGCTCTCCTCGCCTGTGAGGTAGTCCTCGGGGTTGAAGCCGACGGGGAAGAGGCCCGGGCTGTAGATGTAGACGTGATCCCAGAAGACGTCTATCTGGATGGCGGAGTCGTCCTCGTACTGGCGGTGCGCAAAGGCGTTGAATAGCGCTTCACGCACGGCGTCCATCGGGATCTCGGGCACTTCGCGCCTGTGCAGTGAGGAGCCGTCTATGACGAAGGCACGCCGGATGTTGTTCAGGATGTAGAGCTCAGCTGCGTCGACCATGGAGAAGAGCGTGCCGGTGACTTGCTGGTTGTCGAGGATGTGGACGCGCTTGCTGTCGGCGAAGACGCCCATCTTCAGCATGATGTCCTTTGACGGGACGAAGCAGACGGCAGCGGCGTTGGTGAGCATGCCGTCCTCGCAGAGCAGGCCGAGGCGCGAGAGGACGTCTGTGGGCTCGGTGTAGCTGAACGGTATGCGCTTTGCCTCCACGCCACGCTCGACGTAGCGGCGCAGCGCCTTCTCGTCGACGGCGGAGACCGGGGTGTCCGAGTTGCGGCTGTCCCACGGGTTGGAGCGGTTCTCGCTCTCGCGCATCATCTCGGCCAGCTTGGCGTGGCTCATGACGATGTCCTCATCCGCCCGACGGATGCGGTAGCGCCCGTCGCACGCGTAGGGCGTCTCGAAGCCGGAGAACTCGACGCGCACGTACGCCTTGCCCTCAAGGGTTTCCAGGCGCTCGATCTGCGGGTAGATACGCGGCTCGATGAGCTCGCCGACCTTCTGACTGATGTCACGCAGGGTCTTCTCGGAGACGTCCTGTCCCACGACCTCACCATCGGAGGGGCGTACGCCAAAGTAGAGCGTGCCGTGGCCGTGCTTGTTGAGGATGGAGGCGATGGACTCCATGCCCTCGCGCATCTCGGACGTGCTGCGTTTGTACTCGACGCACTCGGTCTCCATGCCGAGGTTCATGGGTGGCCTCCCTCCTAGCAATCGTGCTTGCTGTAATAGTCATTATACGTGCCAAGAGCCTGTTCGTGAGGATACGCCTGGCGAGGTTGGCACAAATACTGAGTGGCTGTTGCGGCCCTGAGATTGCCTCTGGTGGATGCTGTCGGGTCTCTGGTGCTGGCAAAGACTGCCGAGAGGCGGCCTCTGGTGACGTGAGGCGGCTGTTCAGACAACGGCTGCATTGGGACCTTTGCCGCCCGTATTGGCCAATAGACCGGGTGTGCGCGGGCAAGCAGGATAACGGAGCAGACCGGGTGACCACGTGTGGGGTGTGCACCGCTGATCGGGCGTGACGCACACTGACTCTCGCTAGCCATAATCACCCTCGCCGATTGCGACGCGTGGCCGTACGAGTTGAAGGTTACGCAGACGCTTGCCGCCGTTTGCTATGACGTGTGGTTTCGGTGTCTAGGTGGTCGAAGGAACGTCCGACGACGGTCCACTCGTCGCCTAGGTCCGGCGACTTGGACACGAGGGCTGCCAGCATCCTCGTCTCGGGACCCGTCACGACACCTCCACACGCTCGTCAACTTTCGTGCAGAATGATACCGCCCCGCCGCCAGGAAAGCTACGTTTCCCCCAGACGTCTCTCTGTGCTACCCACTAAAAACCACGAGGGGCCTGTCTAAGGTCACAGATTGTGAGTTCAAGATGTAGGCTTGGTATTCTCTCCGACGGCCTGCAAAGGTGCCAGATTGGCACCTTTGCAGGCAAAGACCCTTTGTAAGCTTGCCAATTTGACTTCTCGAGGCTACTCAGGATGTGGAGCGTATGCCGCAACCAGTTCCTGTGTGCGTAGTTCCAAGAGTAGGTTTGGTGACACTTCCCAGCGCTCGGCACCAGCTGAGTTGCGACCGGCCCATCAAGGGGCTTCCCACGAAGGGCGTCATCTTCTATGATCGGACAACACAAGGCGGCATCGAGGAGCCGCTTCCGGATGGCAGGGGGGCGAAGACGATTTTTTCTGATAAAACGATGATCACAATGCGTGAGATGAGTCCGAGCGACGGTTCTTTGGCTGTGGGCAGTGCCATCTTGGGTAGCAGTGACAGTGGCGGCATCAAGAGGTAGGAGACTTACGTCGTCCGGGAAGAAGGTGAATAGCGATGGCGAACATCGACATGCGGCTCCCCGAGAGTGACACGTCACTTCTTGCCGGGATGATCGGAAAGGCCCTCGGTGAGTTCGTCTATGGTGAGCGCTTCGAGAGCGTTCCGGAAGAGGCTCGTAAGTGGCATCGCGTGAACCGTGAGGTCGTGAGCCCTTGGGAGAGGGGTGAAAGTTGTGGATAGCACGGCTATGGGCATATCCACACCGCTTGGGGTTGTTGGGCTCTGGCTCGACGGTAGGCCCTATGCCCACGACGGCCTCTGGGAGGTCGTTGACCGCTCCGACTATGCGACTTGGCATCCCGTGGACGGCAACGTGCGCATTGCTCATTGGCATGAGCCAGACGGGGCCGCCCACACGCTCGCATGCAGGCTCGACCCCTCGCATGGCTGTGAGGGCGGCTTCGCAAGCGGCGAGAGGCTGGAGGCCACCGAGATAGACGACGGTCGCTCGCGGTTGGTGATCGCCGTGGAGTACGACTTCGAGGACTACGCGCAGGGACATGGCGAGTACGAGTACGACTACCAGGCGACCGCTGCCGACCTGGCCGCGACGGTGGAGCTTCCCGCCGACGCCAAGCCCCAGTGGATCGTCTTCGGTGTGTCATGGGTGGAGGAGGTGGATGACGAGAACGGCACGAACCCTTGGCTTGTGGGCGACCCTAACGGCGACCGGCTTCGCATGCCCATGGGCTCCTGCACGAGGAACGGCTCCGGTATGGCAGCGGGGCCGTCGACTGGTTCTTGCCGATAGAGCCCTTGGGAGCGTCAAGACGACATCTTGGCGATCTTCGATGGCTGTGAGATCGTGGAGCACACTAACGCTGAGGAAAGCTATGGCCGTCTCTGTGACGAGGAGATCGTAGTCGATGTCGCTAACCCTCGCTGCGGCGAGGCCATATGGATGGGGTTCGGTAACGAGTACGCAGTGGGTATCGATGGGTGGCACGTGCACTACGACTCCTGCGAGGTCGATTACCGACAGCTCAAGGACGATATCGCCGCGATTCTCTCGGGCGAGATGTGCTTCCTCGCTGCCTTTGCCGGAGACGGGGGTTTTGGCCTTAGCTCGGGAAGGGTCATGGAGAAGATCGGTCGTACGCCCTCAATCTTTCTGGCTGGCAGCCTTCAGTGCATTGGGTTTCTGGTCTCCTCCCTTCTCATTGAGGCCGGAATGGTACCGTTCACCTTGGGAATCTGCCTCTTCTACGCAGGCCAGGGCCTCATGTTCTCACCCATCACGACCATGGTGCTTGGCACCTTGAGTGCTTCGCAAGCTGGCCGCGGCATTGGCACGAACGATCTTGTCATGAACGTCAGCGGCTCGATTGGCATTACCATATTCGGCTCCATCATGGGCACCACGGCGCTTTCCGGCCTCAGCCTTATCGGTGCAGCTGGCAAGACGGCGACCTATTCCAACCTCCTGCTCATATATGCTGCCACCATGATGTTGGGCATCATTGCCTTCGCCTGTTTCCGCAAAGCCATCAACCCAAAGGAGCGATAGCCTATGAAAAAGGTCATTGTCTTTGGAAGCCTCAACATGGACCTGACGATTGAGGCCGATCGGGTTCCCTACGGCGGCGAGACGCTGCCCGGGAGGAACTTCCTCTCCAATCCGGGTGGCAAGGGGGCGAATCAGGCCGTGGCTGTGTCCAAGGCGGGGGTTAGGACCCATCTTGTCGGAAGCGTGGGCGCTGACGTCTTTGGCGATCTACTCCTTGCCCGGGTCGCCTCGTACGGTGTCCAGTGTGACGAGGTCATCCTTCGTGAGGGTGTGGGGACGGGCATCGCCATGATCTGTCGCGTCGACGGGGATAACCGGATTCTTCTTTCAGCAGGCGCGAACCACTCGCTTAGCGCTGCAGACGTCAAGGAGGCCCTTGACAGGCTTGCGGAGCCGGGTGATGTCTTCCTGACGCAGATGGAGTGTGACTACGCTACCACCTGCGCAGCCATCCAGGACGCCCACGGGCGCGGCATGTACGTGGTTGTGAACGTCGCCCCGCCCCGGGATCTCCCGCAGGACGTATGGTCTTGCATAGATCTCGTCTGCGTTAACGAGACCGAGTGCGCGGCCATCTGCGGCGTGCTCCCCGAAGACGATGGGACGCTCAGGCAGGCACTGGACCTTCTCATCAAGAGGGGCGTGGGATGTGCGGTCGTGACGCTGGGAGCAGGCGGCTCTGCTGCGCGTGAGGGAACACGACTTTACCGTGCCCCCGCCGCCCGCGTCAACGCGGTGGACACGACGGCATCGGGAGATACCTACCTCGGCGTGCTTTGCGCGGCATATGTTAACGGGATGCCGATGGAGGACGCCATGAGGAGGGCAAGCGCGGCAGCCGGTATCACCGCATCCCGCGTCGGGGCACAGCGGGCCATTCCAACGGCCGCCGAAGTCGACGCCTTTATGCGCGAGGCCTAGGAAAGCGATGATAAAGTCGCCGATCCCGTCCCTTCGGGACCAGCATGGGTGATTTTTGACGTGAGGAGGGCTCCAACGCCCCCAAGCGGGCTACGCCGGTCTCCGGGGGCCATGCCGCAGCCTCCCAGACCATGGCGGGACGGCCAGCGGTAGGCTATGCCGCGGCCGGCGCCCCACCCTCCGCCCTCCGTCGCCGCTCCTCGAGCCTCTCGCGTTGCAGGGCTATCCTCTCCGCCGACAGCGCGAGGGGCGGCCCGCAGAGCCGCCGTCCCCGCCTCGCGATCATGCAGCCGGCTGCGGCGACGGCGGCGAAGGCCTGGTTGGACACCTTGGCGAGCCCCTTATAGCGCGTCTTCCGCAGCCCGAATATGTCCTTGACCCAGTGGAAGACGTGCTCGACGACACTGCGGGCGGCCGACTTGGCGGCCTCTGCGACCAGGTCGTCCTCGCCGACCTGCGAGCGCCTCTTGGCGACGATCCACTCGACGCCGGAGAGGGAGGGGTCGCCGGCGACCTCCGGCCTCCTCCCGACGCCGACGTAGCCGGCGTCGGCCCAGACGCGCTCGTCACCCTCGCGCACGAGGTCGGGGACCTGGTCGAGGTCGTGGACGTTCGCGGCGTCCATGCGCACCGAGTGCGGCACGCCCGTCTCGGCGTCCACGCCCACCCCGAGCTTGTACCCGAAGTGCCAGTTCTGCCCCTTCTTGGCCTGGTGGGCGTCGGGATCCCGCGCGCCGTCGGCGTTCCTCGTCGACGACGGGCTCTCGATGAAGGTGGCGTCCACGATGGTGCCCCGGCTCACGGCGAGCCCTCCGTCCGCGGCGGACCCGAAGGCCGAGGAGACCATGGCCTCGCCGACCCCGCAGCGCTCGAGCAGGTGGCGAAACTTGCACAGGGTCGTGGCGTCGGGGACCTCGAAGGGCGCCACGCCGACGAAGGAGCGCATCGTCGCGGAGTCCCAGACCTGGTCCTCGCACTCGCGGTCGGAGAGGCCGAAGCAGACCTGCACCATGTACATGCGCAGCAGCACGAGGTCGTCGACCCTCGGCCTGCCCATCGCGGGGCCGGCCCCCCTCGCCCCGGCGTCGGCCCCGCGGGCCTCCCTCACGAGGGCGAGCCAGGCGTCCCAGGGGCAGGACTTGGAGAGGCGGTCGAGGAACCGGGAGCGCCTGGTCTCGCGCTTCCGTCCCATGCCCATCTCGACGTCAGAGAATGTGAGCTGTGCCATGCGGATACCCCCAACCTAGTCGCCAACGACCTCGAATTATATCATATCCGCAGGTAGGAGGTATGGATGGACAGCGATCCGCCCCTGTCCCGGGCTTCTCGGCGGGACTTTATCATCGCTTTCCTAGCGATCATCCTCTAGTGTTTCAGCCAAGCTGTGATGCTCATGATGCAGGCTGTCATGCTAGGGGCAGTTCGCCTTCCTGACAGTCTCAGGTTCACGTGCGCCCCAGACGAGGGGTCCGTCGTGCTTTCGATGACGGCGGGCCCCTTTTGAGTCGGCCTTTGCGCGGTTCCCTGATGGGGGCGATGCGGGAGTGGCTTGCACGCGGGTGCTGTGCGTTAAGGCATGCGACAGCGCCGCGTCGCTTTGGTAGCGTGCTGCAAGATTCGGTGTGCCAGCAGCCTCTATGGGCGATATTGGAGCCCGTGCCCGAGACGACGGCTCTTCCTGTCCCATGGCCGCGCGGAGGTTCCTTTCCCTCAACATTATGCACAGCGCTTTCAGATTTACCGCCTGGCGGCGAGAAATGCCACCGGGTGCTAAACGAGGTCGCTGCAGTGCCCCGGCGAACCTATCATTTTCCCGATGGGCGCTTTGCCCGCAGCTGTCGAGCAGGGAGGTATCCATGTCAAAGGACCGAGCAGAGAGCAAGTTCCTTACCGTGGGCCCGGACATTCAGGTCCACTACTGGGACAAGGGCGAGGGAGACGCCATCGTCTTCATCCCGGGCCTTACTTTCTCGGGCGAGATCTTCAGGCATCAGCTCGAACACTTCTCGGACCGCCACCGCGTGATCGCCGTCGACCCGCGCGGCCAGGGCCTCTCCACCAAGACCGTTTACGGTAACGACTACGTCACTCACGGTGCGGACGTCAGGAGGCTCGTGGACGCCCTCAGCCTCGAGAACGTGACGCTCGTGGGTTGGTCCACCGGCAACCTGGAGGTCTGGAGCTACCTGGAGCAGGCAGGCTACGACAAGGTCGCCGGCGTCGTCACGATCGACATGAGCCCGCTGCCGCTCTGTGAGGATCCGGCCTGGTGGACCGAGGGCACGCCTGCTGAGCTCTCCGAGGTGGCCACGCGCGTCCTCATCCACCCCGAGAGCGCGGAGGCCTTCTGGGATGAGTACCTCACGCAGGTCATGATGCAGCGTGAGCTCGACGAGGACGAGCACGAGTACCTGATGGACATGAGCCGCCGCACGCCCCACTGGGTGGCCCGCCAGCTCTTCTGTGACGCCATCCTCAGCGACTACCTCGAGGTCGCCAGGACGGCCGCCAAGACCGTGCCCACGCTCATGTACGTCGCCGAGCACTGGGCCGACGTGGCCGAGCCCTTCTGCCACGCGCAGTTCCCCGAGACGTCCACCTGCGTCATGGGCGGCCACCTCATGGCCTACGAGTACCCGGAGAGGTTCAACGCCCGCCTCGAGGAGTTCCTCGAAAGCGAGCGGCGGTAGCCACGAGTGGTTCGGGCACCTTACCCCTGACCGTTTCCCTTCCCTCATCTCAAGCAGCCCTCTCATGAGGTCGGCAGCCTTACGTTCCCGTGCCGTCGACCTTGGGGGGGTGCGGCACAGGGACGCTTTCGCGCAGCTAGGCCCAGGCCGAGGCCTGCGGACCCCGGCGCGACCCCCCCGCAGCTTGGCGGGGGGTTGCCCGAGCACATTTGCCCAGTTGAGCCACTTCCCATAGTGCCCCGCAGGCTGGCGGGGGGTTGTCCCCGCGTCCTGGTGCACTCGAAACCTTTGTTGGGCATTACAGCATGGCTACGAAGTATCGGTCCGAGATGCCGTTCGGGGTTCTCGGGGGACTGGTCACCTAGGGAAACACTGATTTATTCAAGGCGTAACGCGCCGCAGGGGCCGCCCGGGCAGGCGCGAGAGGGTACCCTGTGGTATAATATCCGCAGGTAAGGGGCATCTTTCTCATCAGTTTGGGGTGGTCCTCACGCGGCGCCGGGGGAGCTTCGCGGACCTCGAGGCATCCGGCCAGAGGCGGCGCACGAGGCGCGAGAGGTTCCTGGAGCAGATGGAGGCGATCGTGCCCTGGAGGGAGTGGGTCGCGCTCATCGAGTCCCACTACCCGGACGGGAGGCGCGGCAGGAGGCCCGTCGGCCGCGGGCGCATGCCCGGGACGTGCCTCCTGCAGGTCTGGTTCCACCTCTCCGACGAGGCGTGCGAGGACGCCGTCCTGGACTCGAGGGCCACGCGGCGCTTCGTCGGCATCGACATGATGTCCGAGCAGGTGCCGGACGCGACGACCCTCCCCGAGTTCCGCCACCTGCTCGAGGGGGAGGGGCTCGGGGAGGGGATGCTCGCCGAGCTCGTCTCCATCCTGGACGAGCGCGGCATCATCATGCGCGGGGGGTCCATCGTCGACGCCACCTTCGTCGAGTCCCCCTCCTCGACGAAGAACCGGGAGCGCTCGCGCGACCCGGAGGCCCACCAGGCTAAGAAGGGCAACAACTGGCACTTCGGGTACAAGGCGCACGCGGGCGTCGACGCGGGGACTGGCCTCGCGCACACGGTGGAGGTCACCGCCGCGAACGTGTCGGACGTGGCCGTGGCGCCGTCGCTGCTGCGCCCCGACGACGAGTTCTGCTACGCCGGCGCGGGCCACGCGGGCGCGCGGGGGCGCCAGCAGGCCCCCGGCCACCCGGACCCCTCGGAGGTCACCTGGAGGATCGCGAGGCGCCGCTCGAGGGTCCCGGGGCGCGACCACCCGGAGGTCTCGTGGGAGCGAGGGATAGAGAGCTCCCTCTCCCGTGTGCGCTCGAAGGTCGAGCACCCCTTCCACGTCATCAAGGACCTCTTCGGGCTCAGGAGGACGAGGTACCGAGGGCTCGAGAAGAACCGCAACCAGCTCTGCGTCGCCTTCGCGCTCGCGGACCTCGCCCTGCTCGCGCAGGCGGGAAGGACCCTGGCCCCGACCTGCGCGTAGGGGGCCGGGGCCCCGGGCGACGCCCCGGAGGGGGCGCGGGCCCGACGCGGGCCGGCGGGCGGGCCGGCCCGAGGCGCCGACGCGCCGCCCGCAGGTCCCCCGGTGGATGAAATCAACCCATCGGCCTATATAATCAGTGCTTCCCTAGCCCGTGCTACCTACCAGAATTCTCAAAGAGTTATAAAGAACTGCGGTATCTATACCACAGGATACCCATGGGTACCTGCTTTGGTGGTCCTCCACGGCATGCCATGCCTTGAATGAAATCAGTGTTTCTCTTAGAATCGGCTCGCCTCGGCAGAGGCCGGTGCTAAGAAGGCACGGTTCTCAGGGGGGGCGTAAGCGCTTGCGCAGCGCCAATGCAAACACTAAGGAGTGCCAGAACCAACGTTCGGATGCCCTGCTGGGGGCACTGCGAGTTTGGCCTGGGAATCTCATGAAGGGGATGCGTATGTTTTGTCTGAATTGCGGAAGAGAGGCCAAGGAGGGGCAGGCCTTCTGCGGAAACTGCGGCAGCAAGCTGCCCGTTGCTTCGGATTCAGTCTCCTCGACTTTCCCCACTCCCGAAGCGCCTGCGACCGTTCCGGTGACGTCGGCACCTTCCTTCGCGTCTCCGTCCCAGGGTGTCTCCTTGCCCTCCGGTCCCGCTGCGCCTGCGGCGAGGCCGGTCCCCACGGCCACCACACCTTTCTCGGCGCCCGCAGCCGCGCCTGGCCCAACGCCTGCGCCCACGCCCACCGTCTCGCCCATGTCCGCATCCACCGGTGTTTCGACCTCGACTCAGACGCCTGTCTCTGCTCAGACTCCTTTTCCGGATCCCACTCCGACCCCAACATTTGGTGCACCCGTGAACCCATCGTCCCAGCCCCAGAGCTTCGCGCCTCAGACTTCCATCGCTGCCGCCCAGCGGGACGCCTCCACGCTGCAGTCCGCCTTTCAGCCCCAGCAGGTGAGTGGGGGCGGCTGGGCAGAGGGTTCCTCGCATGTCCAGGTGCAGGCCACCAGCCTCGTCAATGGGGCCAAGGCTACCTGGTCGACACCCTATGCCATCGTCTCTCTTGTGGGTAAAGTCATCGCGGTCATCGCCCTGCTGATGCCCTGCGTCAGCTCTCCGCTCCTCACGGCCCAGCTGTCATCGGGTGGTTCCTCGCTCTTCTCGATCCTCTCCAACTACACTCAGGCATCTGAGCTGCAGGATATTGCCAGGGGCGAGTGGAGCATGTGGTCCCTCAATGGTCTCGCGAATTCCGTCAATAGTCTTGTGAGCTCTCTAAACAAGGCCTGGGAAGCCTATGGAAGCAGCCTTGGCTCGGGCTATGCCAGCGGCGGGTCAAACCTAGAGCCCCTTGCTAGCTTGATCACCACCTTGGCTACCATCGTCACGATTGTGTGGGCCCTCATGATCGTGGCCCTTGTCTTCACCATCGTGAGACCCTTCGTCAAGAACGGCAGGCCTGCGGCGCACGAGCGGAGGAGCGGCATCGACACGGCTATCCTTGTCGTGGTGGGTTTGCTCTGCCTTGCGTGGTGTGGCATCGTGACGAGCGTGAACGGCATCATAATGTCCACCCTCTCGTCCACCCTCTCATCGTACAACCTTCCGACGGTTACTCTGCCGAACTTCCTTGAGGTGCCCCTGTGGCCTTGGGTTGCCGCCATCGCCTCTCTGCTCATGGCGTTCTGGCCGCGCCTGAGCAGGCGTATGGGTCTTAGCGCATAGGTAGTCTGTCCGTTGCGTTAGCCGAGTGGCCTCTCCCATACGGGGGCGGTTCGGCCTTGGACGCACGAGTCGGTCGTGCGGGTGGGCGTCCGCGCGGATCCCGCAGGGTCGGCTTGCCCCCAGAGGCAAAGAGTGTACACAGATTGGCTAAAGTAGCCTCTTGGAGCTGTTTCGGACCATTTGTGTACACTGTTGTAACGTTGTGGACAGACGTGGGGACGCAAGAGTGTACACAAGTCGGCGAGAATGGCCTCTCGACACCGTTTTTGGCCATTCGTGTTCACTGTTGCTACGAGTTGCGCTGTGAGCTGCGCCGCGAGTTGCGACGCGAGCTGCGTCGGGTGGCACAAGGACTCACGAGCGCCTCAACCGCCATGGCGCGCCGGCGGCGCCCCCTCGGTGGTCGCCTCTCCCCTGGTCGGAAAAACAGGCTCTGCGCGAGTGGTGCCGCCGCTAGGTTTGCGTCTTCGCCGAGACAGCAACCCATGCAAACCCCCGAGGAGCCGTTTGTATTCTCCCCAGAAGGAGTCGGCACATGGCATCCAAGGAGGACATCTCAGGGATGCCTCTCTCCGTCAAGGCTGTGTTCTTGCGGCCTGATGAGCTGCATACGGGGGCGTTGGGCGTCAAGAGCCTCATCTTTTGCGACAACCGTCTCGGGCTAAGCCATCCGGAGGTGCGCATACTCGGAGGTGTGCGCACTCGTCCACGAGGGTCCCGCGCGAGGCCGGGCGGACGTTCTGGGTGTGGTGAGCATCTTCACGTGCGGCCTGCGGAGGGAGCTTGGTCACTCAGCCGCTGCCGGCGCGTCGTCAACGAGAGCCTCTGAGACTTGGGCTTGGACATCCTTGTTGATGCTGTTGTGGACGAGGGTTGCGTTGTGGCGTCGGACAAGCTGCGTCTGTCGCGTACCGCGATAACCCCTCAGACGAAGGCTGGATTCACTGGGTGTAGCTCACCGGTATAGTGCAGTGTCGCGCACTCCCAGGCGCTGCAAGAGCTCCATACGTACGGCTTCCCCTGCGCTACTTCACAAAGAAGGGCATAGGCGAGTTCGATCTGGTCACTGAGAGGAAAGATGGGGCAATCATCGCGCTCGAGATCAAGTCGGGGAGGGGCTACAAGGCGCATGCCGCGATAGACGATGCCCTCAAAATCGAACACTATCACATCGACGAGGCCTACGTTCTGGCCGAATGTCATGTGGGACGTGATGACACGCTGCTTTATCTCCCAGTCTACTCGATCGGGCTTATGAGGAACAGTTGGGCGGGCAGAGGGTAGACGACCTCAAACCGGATATATTTCGCTCGACGGGTAGAGCGCCTCATAACCCGGGGGCAGGTGGTTCAGATCCGCCCCCCGCGATAAAACAGGTTTCTGGATTGATAATTGTAAGCCAGGGCATTCTCTTACAAGCGGGTTTTGACCGGCTATGGGCGAGAATGCGAGACGTGTGGCGCCATCATGTGTCCTGTATGGGGCAGTCCTCGGCGGAAGCGATGGGTAGCCCCTCCCTTGACTCGATCAGTGCCTACTGCCTTGCTAAAAGTCTCAACTTGAATTCTCTGATCTTTGCGGCGTATCTGCTCGTCATGATGACGCCTATGATTACCGTCCCAAACTCTATCCCCAGGCACAACCCGCCGCCAAAGTCATCTGCCTTGTTCGTTAGAACCAGAACTAGGTAGACGGTGGCCGAAGCCAGTCCCGCGAGGAACAACCAATGCATCCTCCGTGTGATTTTCAGCTTTTCTTCTCCACTGTACTCTGCGACCTGCAATGCCGTTTCCCTCAGCTCTTCGTTCATGTGCTCACCTTTCCTTTCGCCGTTTAGGATTTCGCGCAGGTCGACTTCGTAGAAGTCAGCCAGCTCAACCAATATGTCAAGATCCGGCATGTTTCGTCCGGTCTCCCAGCGAGAAACCGTCCTGCGCGCCACGCCCATTCGCTCTGCCAACTGTTCTTGAGTTACATTGCTTTGCCTCCGGAGCTCCTGAAGAAAACTTCCTACCTTCACCATATCCATTCCTAAATGCCCTCCCTTCTGATTCCAACGTACAGCTTGCCCTCCAGACCGACAAGGACATGAAGTGAGCAAATGCTCCGTTTGCATTGATGAGACACGACGTGTCCCGAAGCTCTGATCAACTTAGAAACAAGTCACCTGAAGAGCCCATAGAGGTGCACCCAGACGTTGAGGTTGTGCATCTCGTCTCAGACGGTGGCGAGCTGGATCTCTTCGAGTGGGACGCAGTACGCCCCGTCCGTGCCGATAGTTCGTCACAATCCGTCCTTTGATAGGCTGAGACAGCTTGCTTATCTCGCGCAGGTCTCGCTGCCGTTATCGTCGGGCGCCGGATTGTCTTTCTGGCACACGACTTCGCCTGCCCGTACTATACTTTGATATTTTGTTAGGTTCGCTGATAAAGGAGGAAGCATGGCGGAGAAGCCAGAGTGGGTCAAGAGCTTCGCCAGGCCTAGGGGTACCGAGATCAAGCACATACGGGGGCACTGGTACCTCTATGAGAGGGGCAGTATCTACGACCCCAAGATCAAGAGGAGTAGGAAGAAGTCGGGACGATGCCTCGGCAAGATCACGCCCGAGGGACTTGTCGCCAGCGTCAGCCGCAAGGAGAGGGCCGAGCGTGCGCGGGTGGCAGGCTTCACGGCTGCTGGGTGAGGCACGGATCCGGTAGGGGTTGGGCACGCGGGTGCAAGTCATCTCGGACGTCGTGGAAGTGGGCGTCCCGATCCTGGCTGGTGGGCCGTGTCGGTTCAGGTTGGAGCTGGGGTACTCTGCGAGAGGCTTGGGGTGGGCCCGTCAGACCGCTCATTCCTCAAGAGAAGGGTCGGCAAGCCAGACTCGCGAGCGAGAGGCGGTATCCACACGTGGTTTGGACGCTTTGTCCTCGCCTGCTTCTTCTCCTCTCATCTTAGGAGGCTTCGTGAGTTCGTGTGGGTAGGTGGTTGCGTCACTGTCCCGGTGGCGTGGGCCTCAGGTCCGAGCGCCCTGGCATCACGGGGGCCATGGGGCCGTCGGTGTCGTGGGGCCCGTGGCCCCGCCCGGTCGCGCGAGCCCAGTCTTGTCGCCCGCCGCTCAGGTGCGGGCACCTGCGGGCTCGGCTTGCCCCCAGGGGCAAAGAAGTGTACATAGATTGGCTAAAATGGACTCTTGGAGCTGTTTTGGACCATTTGTGTACACTGTTGCGCCGTTGTGGACAGACGTGGGGACGCAGGAGTGTACACAGATTGGCAAAAACGGCCTCTCGGCGCCGTTTTGGGGCATTTGTGTACACTGTTGCGCCGCGAGGATCGTGCGAGCTGCGATGCGAGTTGCGACGCGCACTGTGTCGGGTGGCACGAGTGGCTCAAACGCCATGGTATGCCGGCGGCGCCCCCCGGTGGTCGCCTCCCCCTTGGTCGGGAAAACAGGCTCTATGCGACAGGCTCTGCGCGAGCGCCGCCGCTAGCTTGGCGTCTTTGCCGAGGCAGCAACCCATGCAAACCCCCGAGGAACCGTTTGTGTTCTGCCTAGTAGTGGAGGCCCTGGTGCCGCCTCAGGGCGCACGCACGCCTTGCGCGGCCCGGTCGTGCGCCCGGCCGCGAGGGCCTTCCCGGGGGCGAGCCGCCGCCCGCAGGGCAAGGTGACCGGCCAGCCCCGTCACCGGGCGCCGCGGGCTATGCCGCCCGTATGGCGGTGCGTGTCGCGTCAATCTCATCTCGCCGCGTTCGAGAGGGGGGCGTCGAAGCGCCCTCCGGCAAGGGTTCCCCAAGGGCCGTCGGATGACGTCAGCTGCCGAGAAATGGCCAGGTTCTCCAAGAGCCGAGAGGAGCACCACGCCTGGTCCGGTCGGTACGCGACCGAGGCCCACGACCCCCCGCCCAGGACGGGGAGGGCCGAGCGCGAGCACGTGGCCTCGTGGTTCGGGGCGAACCCCACGATCGGGTCGGGGGCGCACTCCCGGCAGTCGGGCAACAGCAGCGCCAAGGTCCGCTACGACCGGCCGCAGGGCGCCGCGCCGCTGCCCTAGGTGGCGGAGATGGTCGACGCCGGCGGCGAGGCCGTCGGGAGGGCCTCTCGCGTCGCTGCAGCCCGTGGCGACCGGCGCAGGGCCTGCCGGGCCGTGGGGGAGGAGATCCCCTGGGATACGGTGAGCTTGCGCCACCCGCGCCGAGCCCCCCTTCGTCCGTCGCGTCCCGGGAGTCCACAGAGGCGTTGGTGGGGGGCGGTCATCTCAGGCGGTGAGGGAGTAGGGCCTTCCTTTGTGCCCTGCCGGGCGGGCGGCGTAAGGCTGCGGTTGTCTCGAGTCAACAAGTTTTCCCCAAAATTTCAGCTGCTTCCAAGAATGAGCAGTCTGTTAAAATTTGTTGCGCATGTAATGCGGCTCACAGTCTCATCGGGGAAGCGGTCTATGAAGCACTCGGAGTTTGTCGATTTGGGAACCAGTCCGGCGGAGGCCCAGGCACTCCTTATGGATTTCGAGAGCGTGGCCGTCGCCATGCGCATGCCGCGCACACTGCGTGACTCGCCGCCAAAGGGGTCCGTCACGCCCGATGGCATGAGCATCACGTCTGCGGGAATGTGCCTGATTGACCGGCTGCCCAGAGAGGTGTGTTGATGATCAAGCTCACTACCATGACCGTCCAGCTCATTGACTGCAGGCCTGACGGCATACGCATCTGCCACGTGGAGGGCGAGTCCCTCATCACGGTCGTCGTCCCACGGGATTTGCTCTCCAAGGCGAAACAGCTGCCTGATATCCCCAAGCGCGGCATCTACTACCTCCTTGATGAGGGGCACGGTGTCATCAGTCGCGTCTACGCAGGGCAGACGACGCAGGGGCTGCGGCGGCTTGACGCGCACAAGTCTGCCAAGGACTTCTGGAACACGTCAGTCATGTTTTTGGATGACGAGGTGAACATTGACCGAGACGTTCTCGATGCCCTCGAGGCGAATGCCATCGACTATGTACGCAAGCACGGCTCCTACGAGACCGACAACTCAGACACGCCCCAGCCTTACGTGAGTCCCTACAAGGAGCAGACCGTCCAGAGCCTGCATCGGAGCATCCTCTTCAGGATGGCGGCCCTCGGCTATGACCTCAACCGCATCGAGGACGTCCCCCCTCGCCCAAGAGCCAACTGTGCCAGGCGGCATGATGGGCCAGGCTACGACCTCAACCGCATCGAGGATGTCCACTCTTCCGAGGACAAGCTCTTCCACACGAGGAAAAAAGGCGTTGTTGCCACGGGACGCTACGACGAGCGCGCTGACACATTTGTCGTGTTGGCTGGCTCGCAGGTGGATCTCTCCCGGCCCGTGCTCAAGAGCTCCATTGCCGCAGACAGAAGGTGCGAGCTCTTTGGCGATGCGGAAGGAATCTGCCTTCTGGGGAACAATCAGAGCTTCAACAGCCCGAGCGCGGCGGCGGTGTTCGTGCTGGGTGGTAGCCAGAACGGCTGGATCGAGTGGATAAACGACCAGGGCCAGACCCTCGACTACGTTTACCGCAGAAAGAAGGACTGAGAGGCACATGAACAAGCAGCAGCTCGCGGCCAAGATCTGGGCGTCGGCCAACCAGATGCGCTCAAAGATCGAGGCCTCAGAGTACAAGGACTATATCCTCGGTTTCATCTTCTACAAGTTCCTCTCCGACAAGGAGGAGCGATTCCTGGCCGAGAATGACTTCGACGCGGATGCGATGTCATGCGTCACCGAGGATGACGCCGAGGTGCTGTCTTTTGTGCGAGATAATCTTGGTTACTTTATCGCTGCTGGCGACCTGTACTCTTCTTGGCTCGATAAGGGCAGCGACTTCGACGTGTCCGATGTGCGCGACGCGCTTTCGACTTTTGAGCGGCTCGTGAGGCCGTCGTACAAGAACGTTTTCGATAGGGTTTTCGAGACGCTGGAGACCGGTCTCTCCAAGCTGGGCGAGACGTCCGGCGCCCAGACCAAGGCCATCAGTGCCCTCCTGCAGCTCATCCGCAGTATTCCCATGGACGGGCGGCAGGGCTACGACGTGCTCGGTTACATCTACGAGTATCTGATCAGCAACTTCGCGGCCAATGCCGGCAAGAAGGCTGGCGAGTTCTATACGCCGCACGAGGTCTCGGTGCTCATCTCTCAGATCGTGGCGTCAAACCTACGGGATCGCGTGGAGATACGCATCTACGATCCCACCTCCGGCTCGGGCTCGCTGCTCATCAACATCGGCGAGGCCGTGGCGCGGCGCTTGGGCAGCCGCGACTCCATCCGCTACTATGCCCAGGAACTAAAGGAGAACACCTACAACCTGACCCGCATGAACCTCGTGATGCGCGGCATCTCGCCTGACAACATCGTGTGTCGCTGTGGTGACACTCTGGAAGACGACTGGCCATGGTTCGAGGAGGGGCATCCGGAGACCTACGAGCCGCTCTTCGTGGACGCGGTGGTGTCAAACCCACCCTACTCCCAGCGCTGGGATCCAGACGGCAAGGAGAACGACCCGCGCTTTGATGGCTACGGCATCGCCCCCACGTCTAAGGCCGACTACGCCTTCCTGCTGCATGACCTCCATCACCTGAAGCCCGACGGAGTGATGTGCATCGTCCTGCCGCATGGCGTGCTCTTCCGTGGGGGCGAGGAAGAGAGGATTCGCCGTGCGCTCGTGGAGAACGAGAACATCGATGCCGTCATCGGGCTTCCCGCCAATATCTTTTTCGGCACGGGCATTCCCACGATCGTGATGGTGCTAAAGAAGCGCCGTCCGACCGATGACATCCTGATAATCGACGCCTCCAAGGGCTTCGTGAAGGAGGGGAAGAGCAACCGGCTTCGCGCCTGCGACATCCGTCGCATCGTGGACGCCTACGAGCGGCGGCGAGACATTGAGCGCTTCTGCCGCGCGGTGCCCAAGCAGGAGGTGCGCGACAACGGATATAACCTAAACATCCCGCGCTACGTTGACTCCTCCGAGCCAGCTGAGACCTGGGACATCTATGCGACGATGTTTGGTGGGCTTCCGATCTCTGAGGTCGAAGCTCTCAAGCTTTATTGGGATGCGCTTCCCAACTTGTGCGAGCGGCTCTTCGAGCCGGCGGGTGGTTCAACGCTCAGACTCCGCGTGGATGACATCGAGGCGGCCGTGCACGACAGCACCGCTGTGCGCGCCTACCTTGACGCCTACGAACGGCGCTTCTCGGACTTCGAGATGTGGCTCTTCGATAAGCTCGTGGATGAGGCCTTGCTCGTGGACCGAGCAAGCGAGGAGGACGTCCTGGCTGCGGAGGTCTTCGGACGCCTTGAGGGTGTGCCCCTCGTGGATCCCTACGATGCCTACCAGGTGCTCGACGACGCCTGGCGACAAGTGTCTGAGGATCTGGAGGTGCTGCAAACCGAGGAGTTCGATGCCGCCAAACGGGTCGACCCCAATATGGTCGTGAAGAAGAAGAGGGGTAGGGACGTTGAGGTGCAGGAGGGTTGGCGCGGCCACGTGCTGCCCTTCGAGCTGGTGCAGCAGGAGCTGCTCGCAAACGACCTCGCCGACATCCGTCGCATGGACGAACGCTCCTTGGCCATCGACGCAGAGCTTTCCGAGGCGCTGGAGGGCCTCTCGGAGGATGATAAGGCGGCGCTGGGAGGCGCCGTGAGCGACAACGGGGATGCCTTCGTGGCCGGAAGACTCAAGGCCTGCGCGCGTGAGCTGCACGCCGACGGCGACTCGGAGGAACTCGCGCGTATCGTGGAGAAGGCCTCCAAGCTGTTCGACGAGCAGAAGCGCTTGAAGAGGCAGTCGAAGCAACAGGCCATCGCGCTTGAGGCAAAGACCAAGGAGGTAATTGAAGGGCTGTCCGACGAAGCTGTACGGAACCTTCTTGACGCGAAGTGGAACAGGCCGATCGTGGACGGGCTCGCCGCGCTGCCCCGCGCTAGCGTGGATGCCTTGGTTGAGAGGGTCCGCTCCCTCGCCGATAAGTATAGCACCACGTTTTCGCAGGTGGAGAAGCAGATCCACGACGAGGAGCGAAAGCTCTGCGACATGCTGGGGGAGCTCACTGGTGATGAGTTCGATATGGCCGGCATACGCGAGCTGCGTGCCCTTCTGGGGGGCGACGGCCGATGAGCGCTAACGTGCCTGAACTCCGCTTCTCGGGTTTTGCTGACCCTTGGGAACAGCGTAAGCTGGGGGAGCTGGGTGTAACTTATGGTGGCCTGACCGGTAAATCGAAGGAAGACTTCGGTCATGGTGATGCAAGGTTCGTTCCGTATACGAACGTTTTCGACAATCCCATTGCCGACTCGACGAGGCTTGGCGAGGTAGAAATTGATGTGAGTCAGAATCGCGTTCTGCATGGTGATACTCTTTTTACGGTATCTTCCGAGACACCCAATGAAGTTGGCATGTCGTCCGTCTGGCTCTCCGACCTCGACAACCTGTACCTGAACAGCTTCTGTTTTGGGTATCGGCAGGATGGTAGTTTTGATCCGTATTACCTTGCCTACATGCTGCGATCGCAGTCAGTTCGTGAGAACATCGAACTGCTCGCCCAGGGTATCTCGCGCTTCAACATCTCCAAAGGCAAGGTGATGGAGGTTGAAGTTCCTGTGCCGATGATGGCCGAGCAGCGCGCCGTCGGCGCCCTCTTCTCCCGCCTCGACTCCCTCATCGCCCTTCATCAGCGTAAGCATAATCAACTTAGTGTTCTCAAGAGCTTACTTTTGGAGAGGATGTTTCCCAAACCAGGGTCCGATGTGCCTGAACTCCGCTTCTCGGGTTTTGCTGACCCTTGGGAACAGCGTAAGCTGGGGGAGTTCGGTTCCGTTGAGATGTGTAAACGCATCTACAAGGAGCAGACATCGGAATCCGGTGAAGTGCCATTCTTCAAAATCGGTACATTTGGTAGTGAACCAGACGCATTTATCTCAAATAAACTGTATGAGAGCTATAGGGATGAGTATCCATATCCGGAGCCGGGGACGCCACTCATCTCTGCCGCCGGTAGTATTGGCAGGACAGTTGTCTATCAGGGAGAGCGTGCTTATTACCAAGATTCGAACATAGTATGGCTCGACCACGACGACAATCTGGACAACTCGTTCTTGGACGTATTTTATAGCCAAGTTGACTGGAAACTTGAGGGCAGCACGATTAAGCGACTCTACAACAAGGATATCCTAAACGCCGAGGTATGCGTCCCTTCGCTCCCCGAGCAGCGCGCCGTCGGCGCCCTCTTCTCCCGCCTCGACTCCCTCATCGCCCTTCATCAGCGTAAGCTGGAAAAGCTTAGGGCACTCAAGCAATCTCTTCTCCAGAAGATGTTCGTCTAAGCAAAAGCCCGACCGAGGAGGTCTTCAATGGACCGCAAGCGCGTGATTGACGAGTCGATACACTCCGGAGAGATGGAGGGCGCCTACGTGTCGGCCGAGTTTCGCGAGGACGCCGACGAGTACGTGAGGGGGCACATCCCTATAGAGGAGCTTATGCGCAGGACGAAGCGCCGCTGGGAGCCCGACCGGGAGGGCAAGGGGCCCCATGTCTGACGGGTTCGTCGATCCCTACATCGACCTGCGGACGGGCGTGCTGCGAAATCTGGTGGGAGCGGGGACGTGGGACGAACTGCGCAACGCAGAGGGCGAGCTCGTCGCGATGCGCATGAGCGAGTTCTTGAGGGAGCTCCCCTTGGAGCCGACGGGCACGCTCGATGACCTGAGGTGCATTCACCGCTGGTTGTTTCGGGACGTGTACGACTGGGCGGGGGAGGTCAGGACCATCGAGATTCGCAAGGCGGGCGAGGGGGCGCAGTTCTTCCTGCCTTCCGCGAACATACCGATGGGCATCGCATGGGCGCGCAGCGAGCTGGAGAAGGACGACTTCCTTGTGGGCCTGGCTTCTAGGCGGTTCCCTAGCCGCATGGCCTACCACTATGACAACTACAACTTCGTGCACCCCTTTCGCGAGGGCAACGGGCGAACGCAACGGCTGCTCTGGACCCTCATCTGCCATCATGCGGGTTACGATCTCGACTGGAGGGACGTTACCGGTGCGGAGAATGACGAGGCGAGCCGTCTGGCGGCCGAGGACCGTGACATGGGCGCCCTCGTGTCCATCTTTGCTAGGATCGCTGCGCCGTGCGACCCCTCGGTGCCCATCAATGCCGGCCTGGTGCAGGCTGGCCATCTTGGTGGGTAGGGAGTCATGCAGACCGCGAGGTGGCGCAAGCTCGGTAAGTCCGGGACATCCGGGTGGTCTTCCTCCGGAAGACGCCTACATGAGGAGTCTCCATGCCCCGCCAGTCATCGCTGTGATTTGGCGACGAGGTGCCTGTCCCTGCTGTTGCCATCTCCTATGGGCCGGGGTTGCGTCCGCTGCGCAATCGTGGTGAGACGGCCGCAAGGATGCGCGGTGAAGGTCCCCAAGATGGGCGGTAGACGCACTCCTTCTTCCGTCAGTGGGGTATCCATACAAGCGTTGCTCGACCTTGGAGGGGCGACCTTCTCAGGCGCCTCAACTCGAATGACTTTGCATGTAGCTTTACGCGTCACTACTATAAATGCAGTCTTGTGTTCCCCGTGGGGGTAGCCGTGACGCTCAGCGCCCCGTACGGACGCTCATGTGTCATGGGTAGGGCCATGATTCGCGGCAGCGCCCCGTTGGTGGGAAGGGGAACAAAGAGGCTGATTGTATCGCAGCTGGAAATTGTGATATGAGAGGGGCTTGGTGGTTATGCTCACGTGTGTTGCGCTGCCCTATGGCCTGTTTGCGGTGGGAGGACATCGTGACCCATCCTCGTAGAACACACGCTTGGGAACAGCGTAAGCTGGGGGAGCTGGGTGTAACTTATGGTGGCCTGACCGGTAAATCGAAGGAAGACTTCGGTCATGGTGATGCAAGGTTCGTTCCGTATACGAACGTTTTCGACAATCCCATTGCCGACTCGACGAGGCTTGGCGAGGTAGAAATTGATGTGAGTCAGAATCGCGTTCTGCATGGTGATACTCTTTTTACGGTATCTTCCGAGACACCCAATGAAGTTGGCATGTCGTCCGTCTGGCTCTCCGACCTCGACAACCTGTACCTGAACAGCTTCTGTTTTGGGTATCGGCAGGATGGTAGTTTTGATCCGTATTACCTTGCCTACATGCTGCGATCGCAGTCAGTTCGTGAGAACATCGAACTGCTCGCCCAGGGTATCTCGCGCTTCAACATCTCCAAAGGCAAGGTGATGGAGGTTGAAGTTCCTGTGCCGATGATGGCCGAGCAGCGCGCCGTCGGCGCCCTCTTCTCCCGCCTCGACTCCCTCATCGCCCTTCATCAGCGTAAGCCGGACGCGCTCAAGACTGTCATAAAGTCACTACTCGATAATATACTCGTGTGAGGGGGTCGGGAATGGAGAACCAGGATATCGAGTACAAGGCGGTCTGGCGCGATGAGTACCTGCAGTGGCTCTGTGGGTTTGCCAATGCCCGTGGCGGCACCATCTACGTAGGCATTGCCGATGACGGTGAGGTGGTGGGGGTCAAGAACGCTGACCGTCTGCTTGAGGATATCCCCAACAAGGCCATCGCCGCACTCGGGATCATCCCCTATGTGCAGCTTCATAGAGAAAACGGCAGGGAGTTTCTCGAGATAAGCATCGAGCCGCAGGATTTTCCCATCAACTGCAAGGGACGCTACTACCTGCGGTCCGGCGCCACGAACCAGCTTTTGCGAGGCGTCGGCCTCGACACCTTCCTTCTGCGCAGACGGGGACGGACCTGGGACAGCGTGCCCGTGCCGAACGTGCGGGTACAGGACCTGAGTCGAAAGGCCATGGACTCCTTTTTGGGAGAGGCGCGAGGCGGGGGCCGCATGCCCGATGACGTTGCAGGCGATGACGCAGAGTCGCTGCTGCAGAGCCTGCACCTGCTGGAGGGTGGCCGGTGCACCAACGCTGCAGTGCTGCTGTTCCATCCAGATCCCATGGCTGTGTTTTCCAGCTGCTTCGTGAAAGTCGGCTACTTCAACGGGTCGGAAATCCTCTTTCAGGATGAGGTGGGGGGACCCATCATAGGGCAGGTCGACAAGACGCTCGATCTGCTCTATGCCAAGTACTTGCGGGCGAGGATCGACTATGATGGGGCGCATCGCGTGGAGCGGTTTCCGTTTCCGCGCGCGGCGGTACGCGAGGCCGTGGTCAACGCTGTCGTTCACAGAAACTATGCCTCGACCTCACCGATACAGATTCGCGTCTGTGATGACTGCCTGCAGATCGGCAACGCATGCATACTCCCGGAAGGCTGGACGGTGGACGACCTATTGGGCTTTCATGAGTCAGAGCCACACAACCCCAAGATCGCGCACGTCTTCTTCTTGGCTGGCCTCATCGAGAGATGGGGTCGTGGCGTGCAGCGGATCTTCAGCGCCTGCAAGATCGATGGCGTCGAGTCACCCCTGTACCGCATGGTGGGGAACAGCCTGCAGATAGTGTTCACCGCCCCTGCGGATCGTGTGATGAGGATTGGCGTGCAACAGTCAGATCCTGGCGATGTTGCGACTCATGTTCACGCAGATGACAGGGACGGTGCCGTACTGACGCGACTTGGCGCGACTTGGCGCGACTTGGCGCGACTTGGCGCGACGTACCCGGATTTTGGCCATCGCCTCATGGAGGCGTGGGACGCGCTTTCCGCAAGGGACCGGGGCATTCTCGGGCAGCTCGCGACTGACGGCCCAACTCGGACGGCCGACTTGTCTGACAGCTTGGGAGTCTCGTTGCGAACCGTGCAGAGGACGATGAAGAAGCTTGCGGTGATCGGTCTGGTCTCCTTGCAGGGAAAGGCGAACGAGAGTCGCTATTACCTGAATATCGATAGCGGGAAGGGCGAGTGATGGCTGACATCTTTACCTCTGAGGCTGAGTTCGAGGCGGCTGTGGTCTCTTGTCTCCAAGACCACGGCTGGAAGGGCGGCGTGCTGCGCCAACCCACCGAGCAGGGCCTCTTGGACAACTGGGCGCACATCCTCTACGAGAACAACAAGGGGGACAGGCGGCTGAACGGATGCCCACTCACCCAGGGCGAGATGCAGCAGATCCTGGAGCAGGTCGCGAAGCTGCGTACGCCCATGAGGCTCAACGGCTTTATCAACGGGGGGACCATCTCCATCACCCGCGACAACCCCGATGACGTAGCGCACTTCAATCGCGAGGTGAGCCTGTACATATACGACCGTCGCGACATCGCCAGCGGCAGGAGCGTCTACCAGATCGCCGAGCAGCCCATCTTCAAGGCGAGTTCCGCCCGACTCAACGATCGCCGTGGTGACCTGACCCTTCTCATTAACGGTATGCCGCTCATCCACATCGAGCTCAAGCGCAGCGGCGTGCCCGTCTCCCAGGCATGCAACCAGATAGAGAAGTACGCCCACGAGGGCGTGTTCACCGGGCTCTTCTCGCTCGTGCAAATCTTCGTGGCCATGGAGCCCGCCGAGACGGTGTACTTTGCCAACCCCGGCAAAGACGGCGACTTCTCGCTCTACCGCTTCCACTGGGCCGACTTCAACAACGAGCCCATAAATGAGTGGCAACGCGTCATTGCCACGCTGCTCTTCATACCCATGGCGCACCAGCTCATAGGCTTCTACTCCGTGGCCGACGAGAGGGATGCGACGCTCAAGGTGATGCGCAGCTACCAGTACTATGCCGCCGCTGCCATATCAGACCGCGTACGGCGCGCAAGCTGGGATAAGCGTGGGGCGCGCGGCGGCTACGTCTGGCACACCACGGGCAGTGGCAAGACGATGACGAGCTTCAAGTCGGCCCAGCTCATCGCTGACTCAAAGGACGCCAACAAGGTGGTGTTTCTGGTGGATCGCATCGAGCTGGGCACCCAATCGCTCGACGAGTATCGCAACTTCGCCAATGACTCGACCACGGTTCAGGCCACGCAGGACACCGATGTGCTGCGCTCCCGCCTCAAGAGCGATAACCCGGCAGATACGCTGATTGTGACCTCCATCCAGAAGATGAGCAACATCCACGAGCACGACGGTGGCATGACCGCAGCCGACTTGGAGCGTGTGCGCGAGAAGCACATCGTCTTCATCGTGGACGAATGCCATCGCTCGACCTTCGGAGACATGATGCAGACTGTCCGTCGTACGTTTCCCACGGCCATGCTTTTTGGCTTCACGGGTACGCCCATCCAGGACGAGAACCAGAAGAAGATGAACACGACCATGGACGTGTTCGGTGACGAGCTGCACCGCTACAGTATCGCCGACGGTATCCGTGACCACAACGTGCTCGCCTTTGACCCATACATGGTGTGTACGTATAAGGACAAGGACGTGAGGCGGGAGGTCGCCCTGGAGAAGGCGCGCGCGGATAGCCAGGCCACGGCGCTCGCCGATCCCAAGAAAAAGAAGGTCTACCTGCACTTCATGAATGAGGTGCCCATGGCAGGTGCGCGCAGGCCCAGCGGCGGTTGCGACAAGGGCGTAGAGGACTACGTCCCAGAGAGTCAGTACTCCGGACCGGACGGCGAGGGCAGCCCTGAGCACTTTCGCATGGTGCTCGCCGACATCGTGGACAACTGGGCGACCCTCTCGCAGGGCGGAAAGTTCCACGCGATACTTGCTACGGCGAGCATTCCCCAGGCTATCACCTACTATCGGATGTTTCGCGACGAGGCACCGCAGCTCAAGGTGACCGCACTCTTTGACCCCAACATCGGAAATGACAACCCCGACAACCCCGCGGGCACCATCTTCAAGGAGGAGGGCCTGGTAGAGATCCTCGATGGTTACGCCAAGCTCTATCCGGGCAAGGACTACACCATCCCCACGCACGCTCGGTTCAAGAAGGACGTTGCGGCGAGGTTGGCCCACAAGAGGCCCTACGTCGGCATAGAGCGCCATCCCGACAAGAGACTCGACTTGCTGATCGTGGTGAACCAGATGCTCACGGGCTTTGACTCCAAGTGGGTGAGCACGCTCTACCTGGACAAGGTCCTGGAGTATGAGGGCCTGATCCAGGCGTTTAGCCGCACGAATCGGCTCTTTGGCCCCGACAAGCCCTTTGGCATCATCAAGTACTACCGCTACCCGCACATCATGAAACGCAATGTAGACGATGCGGTACGCCTGTACTCGGGTGATCGTCCCTTCGGCCTGTTCGTGGATAAGCTGGAGGCTAACTTGGAGCATATCAACCAGTGCTACGCTGACATCAGTGCACTGTTCTCTGCCTACGGGGTGGAGGGCTTCGCGCGCCTGCCGGACCCAAATGCTGCGCGTGCCCAATTCGCAAAGCTGTTCAAGCAGCTCTCGGACTACATCGAGGCGGCTAAGGTGCAGGGCTTCTCGTGGGACAAGGACTCGTATGCGTTCGAGTGCGAGGACGGGGCGGTGACCGTCAAGACGGCGCTAGACCAACAGGTCTACCTGGTGCTTGCCCTGCGTTATAAGGAACTCTTTCAGGAAGACGATGGTGGAGATGGACCAACCGACGTACCCTTCGAGATCGACGGCTACCTGACCGAGATTGACACCGGGCGCATTGACGCTGACTACATGAACGAGAACTTTGCCAAGTGGCTGAAGCAGATCGACGAGGGCGAGGAGGCTCAGGCGACACTCAGTCTTCTGCATGGTTCGTTCGCTACGCTCACACAGGAGCAGCAGCGCTTCGCCGAGCTGGTGATTCATGCGGCGCAGCGCGGCGAGCTCGAGGTCATTCCTGGCAAGACCTTCCTCGACTACATCAATGACTTCCAGCAACAGGGAAGGAACTCACAGGTGGAGGCCCTGGTCGCCGCTACGGGCGTGAATGCGGACAAGTTGCGTGACCTGATGGCGCGTCATCCCAGCGCAGACACCATCAACGAGTACGGGAGGTTCAAGGCGCTTGTGGCCACGTGCGACAAGAAGAGGGCCGCGGCCCATTTCGCCGAGAAGGGAAAAGGGCCGGTCCGGCCATCTCAGGTGAACATGAAGCTCGACAAGCTCCTGCGTGAGTTTGTGATACAGGGCGGGATCGACGTGTAGGATAACACGCTTGGGAACAGCGTAAGCTGGGGGAGCTGGCGACCAAGGTTACCCAGAAGAACGGTGATATGGCCGTTACAGAGACCCTCACCAACTCTGCCGAGTCTGGGGTTGTGAGCCAGATTGACTTCTTCGATCATGACATTGCAAAGGAGGAGAGTATAGGCGGTTACTTCGTCGTGCAGCCCGAGGACTTCGTCTATAACCCGAGAATATCGGTGACGGCGCCAGTGGGTCCCATCAATAGGAATCGCTTGGGTAGAGCTGGCGTTATGTCGCCTCTTTATACGGTGTTCCGTCCCGGAGATGATATCGACAACGCATATCTTGAGCACTATTTTGAGACCTCTGGTTGGCATGACTATATGCAGCTGAATGGCAATTCTGGCACCCGCTCAGACAGGTTCTCGATCTCTGACTCAGTCTTCTTCAAGATGCCGGTACCATGTCCCACTCGTGCAGAGCAGGAAGCTATTGCGAATGCGCTGGAGAGCACCGACTCCCTCATCGCCCTTCATCAGCGAGAGTCGCCCTCAGTGACTTACGCTGATGATCAGATAAGGCTGGTGAGCGAGCGCATCACCAAGTCAACGTCCTTGTTTTCCAGCTCTTGGATTATGTGCAGGTATGTCTTCTCTGTCGTGTTCATGCTGGCGTGTCCCAACCGTTTGGCTACACTCGCAATCGATACGCCCGCGAACAGCAGCAACGAGGCGTGGGTGTGCCTAAGTCCGTGGATGGGGATCACGGGGACGCCCGCCTCCTTGCAGAGTCTTGCGAGCACGTTGTTCGCCGTCGAGTTATACACTTTCTTGCCCTGCTTTACGAACATTGGCTCACTTTCGGGGAGGTCCTTGATGAGCACCGAGAACTGCACGATCAGCTGCCAGTCGATCTGTACCTTTCGCACTGACGACCTGTTCTTGGTCGGAACGAAGCCGCCGCCGTTCTTGTAGTCCCACGTCTTGCTCACCGAGAGTGTCTGTTTGGTGAAGTCAAAGTCCACAGGGGTGATCGCCAGTGCTTCAGAGAACCGCAGTCCTGTCTTGGCCACGAGCAGGATGAACCACTCCCAACTGATCTTCTGGCCGAGATTGAGGCCTGCGAGTAGCTTGTGCAGCTCGAACTGGTTGAGATAGCGGCTCTTCTTCGGTCGCGGGGCCTTGCCCTTGATGATGGCCTTCCTCGTCGGGTCCCGGGGGACAAGCCCCTCGTCAACGGCGTCCAGCACCGCGCCCTTGAGCAGGTGACAGAAGTCCATGGTCGTCTGGCGTTCGTGCTCCTTCGCGTACTCGTTGAGTATACGCTGGTAGGCGAGTCGGTCTAGGTTCTCCAACGTGAGGTCAGGCGCCAGCCTCTCGATCCAGCCGAGTGCAAGCTTGTACTTGTTGAGTGTCACCTGCCTCACCGCGTCCTCCTTGTAGACGGCTATCCATTCTTTGTAGTACGTATGAAACAGATCGCTACTCGTCAACTCGTTCAGCATCGTTTCCTTCTCCCCTTCGCTATGGAGGGCGACTCCTATGTTAAGGATGAAGCGAATGCGTATATGGAAACATTAAGTTTTGCGCAGGGACACTTGTGCGGATGAGGGGCGATGATGCAGTCGAGGAGGGAGATGGCGGTGCCCTGCTCGCGTAGGAGGGCCGACTCGACCGCCTTCCCTATCTCCCATGCGGCTGCGCTTGACGTGGCTTGCGTCGGTGTACGAAGCCCGCCGCTCCAACGGTCCGATCGCGCTGCTCGCCGGGCGACCCCCATGTTCTCCGTATTGGCTGACATAGGGGTAGAGAGTTGCCGTGCCGTATCAGAGTAAGGTTAACCACAGCCTTGGTTCAATAAGAACCGCGACCAGGCGGGGCCACGGCTTCCATGACATTGACGGTCTCATGGCTCCCGTGATGCCAAGGTACTCGGCCCTGAGGCCCGCGCTGCCGGGGCGACGACGCGACCACTCACCCACACGAGCTCACGAGGTCTCAGAAATGAGCCGGGTGGGTGCATGCTACTCATGGCTGTCTTCTTTCCGTGCGCCGTATGTGCCCCGCTTGCGCAGGACTTCATCGGTGCCGCCGGCGCACCATGGTGGTTGAGGCGCTCGTGCCACCAGACGCAGCTCGTGCCACAACAGTGTACACAAACGCTCCAAACTGGCACCGAGAGCCCATTTTCGCCGATCTGTGTACGTTCCTTTGTCCCCGGTCCTCAAATATGATGATGGCTAAGAGCATTTCCGTTCCCATTGACGATGGCGCCATCTTCCAGGTGAAAAGCATTTCAGAGATTATGGATTGAGCCCGGCATACAGCTCGTCGAGCGTGACGAGGCAAAGGTCCGCCCTGTCTGCCGCAGCCCTTCTTGTCGCAGCGCTCGTCTCCCTCTTGGTGAACAGGACGAAGTGACGTCTGCTGAAGCCTTTGAGGAGTGTCGAGCGGTGCTCGAGCGTCTTGATGGCTGCGGTCTCGTTGAAGGAGTTGCGCCACCTGCACTCGCCGACAAGGAGCTCCCGCTCCACCCTGTTCATGGCGACGATGTCGATGTCCGTCTCCTCGTGCGCGTCGGGGTCGGTGCCCCACCACTGCCCGAACTCGAGTGCGGAGAACGGGAGTCTCCCGGCGATGCTCTCTCGTTGGACCCACTGCAGGCAGACGTCCTTGAACTGCTTGCCGACGTACGTCGAGAGCGCCTGTCCCGAGCTGGCGTAGGCGGACGCCGCTGCACCCGCACCCTTCTCGATCGTCCCAAGATACCTGCTTACGAATCGGTACCAGTAGGCAAAGAGGGGATCCTTCAGGCGATAGGCCGAGTTCTTCGAGGTGGGGCCGTTCCCGAGAGGCGAGACCTTCTCGATGATCCCGAGGACGGAAAGTGTCTTCAGGTACTTGCCGACGGAGTTCGGGTTCACACCCGCCCGTTTTGCGATCCTCGATGGGGTGGAGTTGCCGGATCCCACGGCATCGAGGATCGAGTTGTATCGTGCCGGCTCATGGAGCTCTTGGCGCAGCAGCATGAGGGGCTCCTCATAAAGTAAGCCGAGCCTGTCGAAGAACAGCTCCCGCACGTTCTCCTCGTAGGTCCTGGAGAGGTCGACCTGAGAGAGATAGTAGGGAGTCCCGCCGAAGGTCGCATAGTATATGACAAGCTCCTCGGGGGGCACGCCTGGGAGCATGCGGGCGGCATCGAGGTAGTCAAAGGGGTTGAGCCTCATCTGCATCGTCCGCCGACCGTAGAGCGGGCTCTTGCTGCCGAGCACCCTGCTCTCCATAAAGCCCTCGTTGCTCCCGCAGAGGATCAGCTTCGTATCTGTCTGCTTGAGGCCGTGGTCAATCGTTGTCTGCAAGGCCGACGGAAGCGACGGGTTGGCCTCGGCCGCGTAGGGGAACTCGTCGAAGACGATGACGAGCGGTGTGTCGGGGGGTTCCTTCCCGACCCTCTCGACGACGAACCTCAAGGCGTCGTTCCAGGACGCGAAGGCGGGGAGCGTTGCGGGCAGCGAGAACGCCGCGTAGGTGGCGGCGCTAAGGAGCTCAAGGTTCTGGTGCGACGTCTTCTGCTGGGCAGTGAAGTAGAGCACCCTCTTGTCCTTGACAAACTCGTCGATGAGGGTGGTCTTGCCCACGCGCCGCCGCCCGTAGATGACCGCCATCTGGAAGCCATCCCTCTTGTACATGCGCTCGAGCGCCGTGAGCTCCCCTTCGCGTGCGACGAACATAGTCCCCTTCCGGTCATTCTTCTCTAGCATATCCGTACCCTTGAGTACCGTACTCAAGGGTATCGTACCCAAGAGTACGGATACCTGTCCTCAAGAGCGAAACAGTCATCCAAAAGTTTGCCCCCATACAGACTGTGAGCTGCTGTGAAGCGGACAAGGAGGTTGCCGCAGCAAGCTCGGGTGGTGTTTGGGCTGAGGCGGTCGGGGCCGTACCCTGACGGCTATGGCGAGAGCGCCGCGCAGGCACGGATGTACGCAAAGTCGCCCTTGCCGCCCGCACCCCATTCAGGGACCTCTTCAAAATCGGCTCACGCGTCTCCATCTTGGGGAGGATGCCATCGTGATCGCCGTCCCCTCCCCCCAAAACCATGGCTCACGCGCCTACATCTTGGCCCTGACCCATGCGACGGCCACCTGCACGCGGTCTCGCAGGCCCGTCTTGGCCAGGATCCTGCTCACGTACCTGCGTACGCTCGCTGGCTCCACGACGAGTCGCTCGGCTATCTCGGCGTTCGAGAAACCGTCGGCGACGAGGGAGGCGACCTCGGCCTCGCGCGGGGTGAGCGACGAGAAGCTCCCCTTGTGCATAGGCGCACTGCCCCTTGGGGACGCCAGTGGGGAGGAGGGAAAGCATCTTCCCAGTACCTTGCGCGTGATCCTTGGCGTGAGCACGGCGTCGCCGGAGGCGACGGCACGTACCGCGTCGGCGAGCTCTGCTGAGGTGACGTCCTTGAGCAGGAACCCCGACGCGCCGGCGGACAGTCCGCCGAGCGCGTAGTCATCTTGGTCATAGGTCGTGAGCACAAGCACCTTGACGCCTGGATGCGCCCGCGTAATGATGCGGGTGGCGTCGATGCCGTCCATCATGGGCATCCGCACGTCCATGAGCACCACGTCCGGCATCTCGTCGCCCGAAGCGGCGGCGAGCGCGTCCACCGCCTCGCGGCCGTTTTCCGCCTGCGCGACGATGCGGATGCCTTCGGCGCCCTTGAGCATCAGCGCGAGTCCAAGCCTCTCGTAGCGCTGGTCGTCGACGACCATCACCGATATCATAACCGTCCCCCTTCGACCGGACTGGCGCCGGCGGATGTGGACGCGGGGATGTTCGCCCTCAGCGTCTAACTGCCCTCGGAGGGTCCGGCAAAGAACGTTCCTCCCGCGCCACGTACGCGACGTTCGAGGCGCGTGAGGCCCGTGCCGGCGGTTGCGGGGGTGAGGTGCGCGTCATCCTCAGGATCCGAGGTGACCCCTATCAGCGACCTCCAGGCAATGAGGCGCACCGTGTCCCCACAAGCCCAAAGAGCACGAGGACGTCGGCGTAGTTGAGCTCTGCGGGCAGGCCGAGTCGGGAGAGGACCTCTTCGAGGTAACGGGCGGCACAGAGCAGCGCCGACCCGCCGCCGAGTGCGGCAGCCAAAGGGACGACCGCGTGGGAGTCGCGCTCTATCTCCTCGATTGCCTCGCGAGCGGCTAGGTGACCCACGGCGTCCCCGAGCGTACGCGGTATCAGTCCCGCAGCGCGGGTGGCGAGACGGACCCCTTCGACCCCAGCGGCGAACACGGCGAGCGTCGCGAGAATGCCGGCGCTTACGATGCCGTTCACGATGGCCCCCACCCCGTTGCCGCCCAAGAGCGCGCCCAGGACAAAGATAACCAGGGAGAGTCCAAGAAGGAGGCCCGAAAGCACTCGTCTTGCCGCCGTTCCCGCGCGGGAGCGGCCCGTATCAGCTCCCGTCTTGCGCAGGAAGTCGACGGGGGCTACCCTCCCGGTTCGGAGGGCAGGCAGGATCGCTCCCGCCATGCAGGTCGGCCAAGACACGGCAAACGCGAGAGGTGCAGCCAGCGCTCCCACGTCGAAGGCTGGTGGCTCAAACGATCCGAGGCCACCCGAGAAGCCCTCGGCAGCCAGCGCGTCGAACGCGGGCACGAGCGCAGACGAGAGGGGAAGGGAGGCAAGCGAGCCTGCGGCCGACCCGATGGCGGAGGCTAGGCCAGCTACGGAGAGCGCTGAGACGCGTACCTGGATGGGCGTGGCACCCGCGAGGCGCCACTGGGCGAAGGTGGAGTGGCAGCGCCTCACGGTGGCCGACCCGATCGCCGTGAGTGCAAACAGGGCGATGAGTGCGACCTCGGCGTAGATGGTGACGGACACGACCTGAAACCCGGTGAGGTCGAGCCGAGCTGCACGGGTGGCCTCGGCGAACGCGGGACCCGACGTCCAGACGGCCTGTGACACGCAAATGCCGACGAGGGTCGAGGTCATTGTGACGACACAGACGAGTGGGACCCAGCCGACGAGGTCCTCGGCAAAGATCCGGATTGCATACCTATGCATGGTCTGCCTCGCTTTCGTGCTCCTTCATGCCGTCAAGTATCTCTTTGGGGGCCATGCTGCCTGCGACGTGCGTGATGCGCCCGTCGCGCATGAAGATGATCACGTCGGCGGCCGATGCGACGTTGGGGTCGTGCGTGACCACGACGACCGCGCAGCCGGTAGATGCCATCTCCTTGAGCGTCGCGAGCACGACGTGAGAGCTGCCGGTGTCGAGTGCGCCGGTTGGCTCGTCGGCGAAGAGGACCTTTGGCGAGAGCATCAGGGCGCGGATGAGTGCGCAGCGTTGCCTCTCTCCGCCTGAGAGTTCCTGCGCTCTCGCCGCGTGATGCCCAGAGAGCCCAAAGCGGTTGAGCAGCGCTGCAAGCTGCGCGGGGTCGCCTCTGTGACCAGCTGGCGAGAGCGGCAGGAGGGCATTCTCCTTGACGGTCAGGTACGGGACGAGGTTGTAGTCCTGGAACACGAAGCCGACGCGCTCACGCAAAAAGCGCGTGCGCTGCCCATCGGGGAGCGCGTACACGTCCTGCCCAAATGCCAGCATCTGCCCTGTGTCTGGGACGTCCAGTCCCGAGAGGGCGTAGAGAAGCGAGGTCTTCCCCGCCCCCGAGGGCCCGACGACCGCAGTCATACCGGGACCGATGGAGATTGAGCAGTTGTCGAGTATGGGAGGGGCGCCCTTGGTGAGCGAGGCCTTGCTCAGGCCGTAGGCTTCGATGATGCGTTCCATGTAGACCCCTTTCGTTCGACTTGCTGCGGTGTTGCGCATCTTTGTGCAGTGGTTCGCCGAAGATGAAAGCACGAAGCGCGGGTCATTTCCAGGCCATGCGGGGCTTTGCCATCTGGAGCGGACAAGGCCCTAAGGCTGCCGCTCGGTCCCGGTACCTGTACGGTGGTAGGCTTATCATGGTGGAGAGGGTCCCTCGCCCTCTGAGGCTGCCCTAGGATTACCGTGCCGCTATCGTGTGCTAAGGTTGGAATGCAGCTCACCGAAGGGGAAGGGGGCGTGAGGCATGGATATGGTTGCCAAATGCGTTGGAGCTTGTTCAGGGGAGGTGCCAGTTCGTCCTCTACCAGGCTACTATCAGTGCTCTGATCCCCATCCTCTCCGCGATGAATTTCGCCGCCGTGCGCACCGGGCGGGACGAGGGCATCAGTCCCCTGAGCGGCGCCGTTTCGACGCTCCGTGCCGGTGTGGGGTTGCGCAATGAGCGGATCCTTGCGGGCGTGCCAAGGCCGTGACCCTCAGGGGGTATGCGGGCTGGAATCTGCCGAGCTGAGGCGTCTGGTCGTGTACGTGCACGGAAGGGGTGGCTCCGCCAAGGAGGCGGAGCACTACAGGGCCCTTTTCCCCGAAAGTGATGTGATTGGCTTCGACTACAGGTCGCAGAGCCCATGGGAGGCGCATGAGGAGTTCCCTCGATTCTTTGGCGAGAGACGCGGCCGCTACGGGTCGCTTGTCCTGGTCGCCCACAGCATGGGGGCGTTTCTTGCGTTGTCCTCCCTTGGTAAGAGACACGTCGACGAGGTGTATCTCGTCTCTCCCATCGTGGACATGGAGAAGCTGATACGCGACATGATGGCGCGCGCGGGCGTCACCGAGGAGGAGCTTTCGAAGAGGCTGGAGATCGAGACGGGCTTTGGCGAGAGGCTGTCCTGGAAGTACCTCCGTTACGTGAGGGACAACCCAATACGGTGGGGCGTCCCGACCCACATCCTGTGCGGCGAGGGGGACGACCTGACGCCCGTCGAGACTACGTCGGCCTTCGCAGGGCAGATTGGCGCGGACCTGAGCGTCATGAGAGGCGGGGAGCACTGGTTTCATACCCGCGAGCAGCTACGGTTTCTCGACGCTTGGCTGGGGCGGCTCAAGCGGGCGGGTCTCGGGTCCGGTGAGTGCGCAGCTTCTTGCTCGACGCGATCCACGTTCCCATCGACGCCGCGTCCCCGCCCATGAACCGATGGACAGGTCGCCCTCAAGCTCGGCAAGGCATGACGTGAGCCATGCGCTTGGCGTACGCGAACGCATCGCGAGATTGAAGTCTTTACACGAACTACCCATAATCCAAGTCTCGCAATGGTAACATTGGCAAGTGGAACGCTAGATTCGACCGTTCTAGAGATGGGGAGATGTCATGGAGTGCACGCCGTAGCCTCGTGAGCCACTTTGTCGAGAAATCCCTGTTAAGACCCAAAAGCCGTCTCGAGTTGGGTGCCCTATACGTGGGGTGCTTTCTGCTGGCAAGCTTCCTCGCATGCGTGGAGCGTCAGGCGGCAGGCTCAGATGTGTTACTGAGATACTTCGAGTTCATGTTGCATAATAAACGTGCCTTCGTTCTGGGGTTCTCTGTGGTGGCGTTGGTGTTTCACTACCACCTGCTGGCAAGCTCTGGAACAGAGATCAGATGCCGGGTGCTGGTAGGGGACAGGCTGACGCTGATACGACTCAGGTACATCATCGAATGCCTGGCATTGCTCGGCATCTGCTGTGCTCTCTCGATCGCACTGCATCTCCTGCTGGGCTTCGAGATCGTTGACAACCTCTGTTTGTTCGCCGTCCTATCCATGTACATCCTCGCGAGCGCGGGTCTTATGGGGGCAAGATGAAGGCCTTTCATTTTTTCTTGACTCGTATATTCCTAAGGAAGCCAATTTTCGCCATAGGCACGCTGACTCTGTTGTTTCTGGCTAACTACATAGTGTTCTCGACGGCTCGTACCGTGTTTTCCGCACGTGAGGGCTACGAGCAGATGGCGCGCATTAACGCGGAGGGAACATTCATGGCGAGCTTGGATCCGGATGCGACGGTAGATGTCGACAGCAGCTCAAAAGAATCGATCCAGAGCGTCTACGATGTCCTGGACGACCGATATGAGTACGCTTTCTACACTGACGGCTACATCACGGACCTAGCTAACAGCCATGGGGTCGAAGTCCCGGTGGGTTACATGAATCAGCGATATAACGAGCTCAACGGCTTTTCCGTCGCGAAGGGAGACGGGCTGACGTTTGATTACAGCCTGGACCAAGGCGAGGCGATTCCCGTTTTGGTGGGCAGGGGGCTCGCCGACGACTATCCGCTTGGCTCGCAGTTCACCATGCATGACCCCGCATTGGGCCGAGAGTTGACGGTGAGGGTCGTTGGCATCATCGCCGAGAACTCGTCGCATTCGATCCTTTATGCGCCTGATTTGAAGCAGTACCACAACTTTTCGGTGGTTATCCCGGTGAACAGAGCTTTCATTGAGCAGGCCGACGCCTTTCTTAAGCTCAACGGGCTCATGGATCTCATTTTAGTTAATACCGATCGTACGGGCGTGTCCGAGCTGGGCGCATATGTCAACAGAACGATTGGGGTCAAGTTCAACTACTATAGTCGACAGGACAACATTGAGTTTTACAACCAGTACCTTGTCTCCTCGACGAGTTCCCTGCTTGTTGTCTCTGGCGCGCTCCTTGTCCTGACCATCGTCCTATCCGTCTGGGGCTCTCTGGCAAGCGTGCGTGTGATGGTGCGCGACTTCACGATCAACGTGCTGGTGGGGCTAAGCTACTCCAAGGTCCGGCGGCTCCTCTTCTCATACTACGCGGGCCTTTCGCTCCTTACCCTGCTTGCCGTTCTTGCCATGGCCGCCTATTCGAGGTACGATGCCTGGCAAGGTAAGAGTGCATTTCTTATGACCTATGGCTGCGCGGGGTTGATCGGGATGGACTGGCTGGCCTTGCTTGTCGCACTACTGCTCGATCTCTTTCTGGTCACGGTGGTTGTGCAGACGATTTCCTGGAGACTGAGACGGGTTCCCATCTCGGTGGGGGTTTTGCAGTGATGGATAACGTCATCGACCTCAAGCTAGAGCACAAGACATATAGGAAGGGCTCGTCATCCGTAACCCTTCTTGAGAACTTCTCGCTCACGGTCGCTGAGGGCGAAAAGCTTGCGATAGTCGGGGAGTCTGGCGTTGGCAAGAGCTCGCTATTGAACATCCTTGGCCTGATTGACAGACACTACGCAGGTTCCTACACCCTGCTCGGCAGATCCGCCCGAGAGCTGTCAGATCGCGAGTCGGCTGCGTGGAGGAACCAAAGGATCGGATTCGTCCTACAGGAGTCGGCGCTCATCAGCTCCTTGAGCATTGCGGACAATATCAAGTTGCCCCTGCTCTACGCGCGGCCGCCCGGCAGCGGCCGGTCAGGTAGGTTTGAGGAGGTGGTGGACACTCTTGACATCGGTCCCATTCTGCGCAAGAAACCGCTCGAATGCTCCGGCGGGGAAAGGGCGAGGGCCGTCTTTGCGCGGGCTGTCATCATGAGCCCCCAAGTAATTCTTGCTGACGAGCCTACCGCCTCCCTTGACGCAAAGAACAGGTCAAGGATCATCGGTCTTCTGTTTGGCCTGAATCGTGACCTTGGGTCTACGGTCGTCACCGTTACGCATGATGCCGACGTGGCCAGCCAGCACGATAGGGTCGTCGCACTTCAGAGAAAGGCATAGGGCACGAATCTCTGCGTTATGGTATTTTCGGAGCCACTCGGGTTGGGCCTGCTTGTTCCGGGAATTAGCTTGGGTAAAAGGACGGACGGGTGTTGTGTCCGGCATGCGAGAATAAGGCCCGCGTCAAAGCGTGTGAGAAAAGGATCCGAAGATGGGATGGTGGAACCCGAAGGCAAAGATCCCCATCGAAAGCGAGGAGTTCGGCAAGATTGTCCGGGACCTCGTCTTCGAGTGCCCCAGCTCGCACCGCCACGAGGTGTCGGACGGGAAGCGCCCAGACGGCAAGAAGAGCAAGAGTAGGTTCTATCAGTCGGTGAGTGCCCGCAACACATCGTTCCACGCGAGGGGGATCAGTGGTGACCTGTTCCTGACGATTCTTGGAGAGATCACAGGTCCCCTCAAGAGGAAGGACAGGTACATCAAGGTTGAGAACGGCCAGACCGTCGAAGAGGTAGCCGCATCGGCGGTAAAGCGCCTAGGGTCTGATGCCATGAAGAGGGACCTCCTGGTCTTCGCTCCGCGATCCGACATGCCCGATACCGAGGCGATCTTCTATTACATCAGAAACGCCTTCGCCCACGGCTCCTTCGAGGTGCAAGATGTCGACTGTAGGAGGATGTACCTGCTTGAGAGCGACAAGAAGGGCAAGCCGCTGGCGATGATGCGCTTAAGCGAGCAGACGCTGCTGCGCTATGCCCAGCTCGCCCACCTGAGCGTTAAAGAGATAAAGAATCTCCGTCAAGGGAAGCGCAAGAGGCCGGAGTAGCGATTCACTTGTCGAGCGCGTTGCCTCGACAAGGAGAGGGACCCTTCCCATCCCACTCGCCGGCCGTCTCTGTGGGCTCGCGCCAAGCCGTGGGGGCTCCATGCTCCATTGCAAGGCTGTCTGGGGCATTGCGGGGCTGCTCCGCAGGCTGGTCTTCGGCCGCCTATAGCAGCCGCCTTCCGCTGTGACCCCCCGATCTTAGCTCGTCCCACTTCGTCGCTCTCGCCATGTCCCTGCACATCTTCCGTTTGGAGCACTCCATGCTCCCGTCCCCACGTCCTGCGGCTCCATCCCACCACTCTCGTCCGGCGGGTGGGATGGTCATCTCGGGTTACGGCAGTCTGTCCCGGCGTCTCTTGCAGTCCAAGCTTTCGTACAGGTTCGTTCACCGTACTCGCAACAGCTTCACCAGTGTATCGTCTATACCTAACTCTCTGTTAGACCACCGTCGGCATGACGACGCCCCGCGTCTCCGCCACGATGTTGTCAGCGAGAAAACATGTCGAGGGGAGACGCGGGGATGCCTGGCATGACACCGCGAGGGGCGAGGGGGCCGGGCGCGTGCCCCAGGTGCGGCGGGACGCGCCTCGTGCGCGAGGGGCGCGACGGGGGCGGGTCGCAGGGGCGGTCCCGCGGGTCCTGCGGCCGCGCCCCCTCGCGCAGGGCCATGGGCCCGCCCGGGTGCCCCGGGCCCGAGGGGGGCGTCCGGGCGAGCCGCGCCGGGCACGCGTGCGCGGGCGGGACGCCCGGGGAGCGCGCGGGGGCCTGCGGGGTGTGCCCGGGCACGTCCCGGCTCGTGCGCACGGGGCCCAGCGAGGCCGTGGGCCGCGCCCCTGCGCCGCCCGGGAGGGGACGGCCGTCTCCTGCCAGGTCGACGGCACGCGCCCCGGCGAGTCGCCGGCCGGCAGGCGGCCCGGGTCGGCGGCGGCGTTGCCCCGGGAGCCGCGGCGCTCGGCGGCGCCGTGCGCGAGCGCGGCATATCGAACCTCAAGGTGTGCGTGGTCTGCGGGGGGCGACCTCGGCGACGAGTTCTGCGAGGTCGCGGACCGGGGCCGGCCGACCGACGAGGCGTACGGCCTCGGCCCTGGGGGCCGTGGGCGAGGGAACGTCCGTCTCGACCGACGGCCTCCGTGGGTACGCCCGGGTGCCCCCCCGCGCTTGCGTGTCGCGCCACGACGCGACGCCCGCGCGGGAGGCCGTGCGCGGCGAGCTCGGCATGGCGGACGCCATGCACGCGAGGCCCGAGGGCTTCCTGGCGCGCCTCGGGGGGTCCCGCCGGGGAGGCCCGGCCACCACCCCGGCTGGTTCCTGTGGGACGAGCAGACGAGGGGGCCGGGCGCCGACAGGGCGGACACCCTGTCGGGCCAGGCGGCGACGGGGAGCTACGACAACACGCGGTTCGCCCTCGCGAGGGAGCCGCAGCCCCTCTGGTCCTACTGGGAGGATAAGCTGGCCATGCCGACGGTGGTCTAACCACAGCTTCCCTCATCATTAGGTATGCGCTGGGGCGGGAATGGGGAACCTCGCCTCGAGCGGCACACCTAGGGTATCAAACAGCCTCCTGACTGACCCCTTGCAGTTGCAGCATCCCCATCTCCCGGCCCGGAGGTGCGCCTTGACCAGGCGGGCGTCGAGCAGCGCCTCGTCGACGGTACGGCCGGGGAGCCGCCCCCCGACCAGGTCGGCGAGCTCCCTGCGCACGAGCGACGCGACGAGGCACACGAAGGCGAGACCCTGCGCGCGGCAGTAGTCGCGCTGGCAGAGGCCCCGGAGGCCCATGCCGTTCTTGAGCCAGTCGTAGTAGGTCTCGATCGCCCATCGTCTCTTGTAGTGGTCCCAGACCTGCTCGGCGGTCGCGTCCGCCAGGCTCGTCTGCAGCACGCACACACCGAAGAAGGGCTCGGCGGAGGCGAAGCCGTCCTCGGTGTAGCCCTTGCGGCCCTGCGCGAGATAGCGCAGGTAGTTTGCCCTCTCGACCGCTGCCTGGTCGCGGTCGCGCAGCACGAGGACGCGCCGCCCGCCGCCCGCGTCGTGCTCCTTCCACTCGACCACCGTCGCCTTGCGCCCGCGCGCCCAGCCGAGCCGCTCGCGCAGGTCCATCTCGGCCACGGCGTCCTTGCATGCCCTGAGCCCCTTGTGCAGCGGCATGATGTAGTCGTTGTTCCCGCTCGACAGCAGCTCGACGTTGGCCGCGCTGTGGAAGCCGGAGTCGACGAGCCACAGCACGCCGTCGAGCGGCACGTCGGCGACCAGGTCGGCGAGCGACGCCTCGCCGGGCAGCCCGCCCTCGACGATGCGGCAGGCGAGCGGCGAGCCACCGAGGGCGTCGTAGGCCATGAGCAGGTTCATCTGGTCGCAGTGGGTGGCGCCGAACCGATACCCCTTGCCGGCCAGGTCGTCGGGGAGCGACCCCGAGCCGACCACGTGGCCGTCGACGGCGACCAGGCGCGAGCTCGCCTCCGCGAGCGCCCGCTCGAACGCGAGCACCGGCCCCTGCCTGCGACCGAGCGCGTCGAGCAGCTCGCCCACGGCCCGCTCCCCCAGGGCGACGGAGGGCAGGGCCAGCGAGAGCGCCGACTGCTCCCAGACCCTCCTGGCGTCCCTCGCCGGCGTGACGCCACGCACGCAGAACATGCAGGCCAGCGCCCATATCCGATCCGCGTCGTCGGCGTGGAAGTGCTCCCCGAGCAGCCCGCGCACCGGTGCCGAGGCCGACAGCGCCACCGCCCAGTCGCCGAACTCCAGGGTGGTGATCTCCGAGCCGGACGCGCGGCCGGAGTTGGGCACGTACCCGCGGCCCTCCTCTATCTTGCCCACGCAGCGGCCCATCCTCGTCCTCCTCCCGCCCTCGGTCACCGAGCGATACTCGTAGACGTAGTAGTGGCCGCTGATGGCCTTGACCATCGTGCCCCTGGGCTTCATCGCCCTGATGTGCTCCGGGACCGAGTACGCGCCCAT

Protein sequences of DBSCAN-SWA_1

>NZ_CP012069|44499:169886|58639_59077_+|WP_050342464.1|DBSCAN-SWA
MCEECYVDESRATPLLRPRDCLESHTQYVCGTCGRCICIEHDPRRGLRRWNFPFRSLEIAKLYLRAADYSMKRPCGIYEMEGAGGRLSYKIFADGEDLRLYLGRNKGKACKGMAPALIVGEYREYAGTQVRRLSPDEVERYLSER
>NZ_CP012069|44499:169886|135580_136414_+|WP_050342587.1|DBSCAN-SWA
MSKDRAESKFLTVGPDIQVHYWDKGEGDAIVFIPGLTFSGEIFRHQLEHFSDRHRVIAVDPRGQGLSTKTVYGNDYVTHGADVRRLVDALSLENVTLVGWSTGNLEVWSYLEQAGYDKVAGVVTIDMSPLPLCEDPAWWTEGTPAELSEVATRVLIHPESAEAFWDEYLTQVMMQRELDEDEHEYLMDMSRRTPHWVARQLFCDAILSDYLEVARTAAKTVPTLMYVAEHWADVAEPFCHAQFPETSTCVMGGHLMAYEYPERFNARLEEFLESERR
>NZ_CP012069|44499:169886|71129_71804_+|WP_050342484.1|DBSCAN-SWA
MDFHILESSWLFQGLSAERIKELFQGIPSIIQRYEKDETIFQPLETADRVGVVLKGSVQSYKLFPNGSQVNVTVRQAGDIIGSAAALSVQKKYPSGVVALEHTEILMLSRDDFLRLLKRDPHLVENALFEISTITYMLQQRLELLSYHGIDQKIAFCLLTQSAQSGEAVIPIPGSMTKWALMMNVSRPSLHRELKRLEEQGLLCHTPALIKILDPPALGKLLRR
>NZ_CP012069|44499:169886|80247_80793_+|WP_050344648.1|DBSCAN-SWA
MSDLVFIVPALGIPALVSALEWTLLNDIVERHHSHHDTYRVSNTLTHTLVMVMVFMGFLGVVLGWLCNVGVFRANSHVLLAFFLSFLGVSLLIWTWLHRYKVVTYDDCMHITPPIGTRRTIRYDEIESMEWHRSKSLLGYENLRVRVKGSYWCVTLWGMLDLEQILMRINRYDAIDSEGVY
>NZ_CP012069|44499:169886|114096_115260_+|WP_083443699.1|DBSCAN-SWA
MTNSAGEDDIVLVLDIEASSSHVISRLSDGEVFLRQNDRSVRLTRGQVLALEYDKGQRAFEDELIEDSSIEDVDHEVLDRYKGVLGTDLPDEQVLRSRRFMRDGKLTVAGALLFAGDPSAMMPQARVRVLRYDGTRAETGKRLNITKERVFCGPLPRVIEGAYSLISGMLREFQFLASDGKFRTVPEYPEFAWFEGLVNAVTHRDYAYRGDYVRVSVFDDRLEIVSPGALPNIVTLDNMMTTRYSRNPRIARTLVEFGWVRELNEGVPRIYSEMQSMLLKDPTYSEPGGAKVQLTLENNIVARTVRRHEALEDRLTEGVVSALDEYELAAVRLAFTNGRVTAKELAERIGRSQRTATRVLKGIAGPGGLLEWHGSSINDPRQFYALR
>NZ_CP012069|44499:169886|60604_61597_+|WP_050342469.1|DBSCAN-SWA
MSFRDNLQHLRATRNMTQEQLAMLMGVSRQSVTKWEAEKAYPEMDKLLKLRDIFGCTLDELVQGDLTTRPKEPGLGIAEGPAQDVCGYEEHMRQHARNMAVGIPLIILGMAGAAFFGELGHNMLPIDNDALSGLVFLALTLVGLCFIIPAGLRHDAFAKAHPYVEDFYTATQREAANRLFSRGIVGGIVAIFVGLMLAVGLDDSVFWTGSAFLACVAVGVALLVYASLMHDRINVDEYNNAALENLSDDEIRELGAGDADALVIQKHRSARLGATCGIIMLVVTAIALSLLFLSPYLGTASAAASSFFWLPWLIGGLACGIVSLIYNMRG
>NZ_CP012069|44499:169886|77290_78244_+|WP_083443689.1|DBSCAN-SWA
MIIDEAQRVPELFNAIQVVSDERGTVGQYILLGSQNYLLLRRITQSLAGRIGLVRLMPLSYREVALAPNEVTPDGFMLRGGYPRLYDVDIPSYVYFENYISTYVERDVSEYVDARSKGPFRRLLMLCAQSCGSLLNVSRIASDLGVARATVDSWLSILEASYTIFRLQPYHANLRKRLTRTPKIYFCDTGLLCHLLGVETSEQLRDSEMRGAIFENLIVTETAKRHLNAGRTPRLFFYRDDSKIEADLVDDSDLAGRELIEIKSQVGFRKDFLRHLPVVGRDLGIAERRRYVVTRGADSFSVGGMKVWAARDWLMRP
>NZ_CP012069|44499:169886|63768_64305_-|WP_050342473.1|DBSCAN-SWA
MYLTEYRTPTIGTLTLASDGTGVTGCWFNNGRYFGYGVNESMERSDSLAVFDRVRRWLDRYFAGETPDPRELTLTARATEFQLRVREAMLDIPYGQTTTYGAIAKRLEAETGRRQSARAVGGAVGRNPLCLIVPCHRVIGSNGSLTGFGGGIDTKVRLLEHEGAMRDGFWRPKRGTAL
>NZ_CP012069|44499:169886|147724_148933_+|WP_050342613.1|DBSCAN-SWA
MSANVPELRFSGFADPWEQRKLGELGVTYGGLTGKSKEDFGHGDARFVPYTNVFDNPIADSTRLGEVEIDVSQNRVLHGDTLFTVSSETPNEVGMSSVWLSDLDNLYLNSFCFGYRQDGSFDPYYLAYMLRSQSVRENIELLAQGISRFNISKGKVMEVEVPVPMMAEQRAVGALFSRLDSLIALHQRKHNQLSVLKSLLLERMFPKPGSDVPELRFSGFADPWEQRKLGEFGSVEMCKRIYKEQTSESGEVPFFKIGTFGSEPDAFISNKLYESYRDEYPYPEPGTPLISAAGSIGRTVVYQGERAYYQDSNIVWLDHDDNLDNSFLDVFYSQVDWKLEGSTIKRLYNKDILNAEVCVPSLPEQRAVGALFSRLDSLIALHQRKLEKLRALKQSLLQKMFV
>NZ_CP012069|44499:169886|84329_85280_-|WP_050342502.1|DBSCAN-SWA
MFSVTALGELLIDFTDAGTSAAGQKLFERNPGGAPANVLVALERLGKSTAFIGKVGRDMHGEFLNATLVANDVNCDGLVLDPNCFTTLAFVALSEEGERTFSFARKPGADTQLRPEELRRDVIENSRVFHVGSLSLTDEPARSATIAALDVAKAAGAVMSYDPNYRDSLWTSAEVASEQMRSIVTYMDLIKISCEETELLTGRSDPTEAARILLGQGAQVICVTLDDEGALVATKDGSATVPSFKVDAVDTTGAGDSFWGGFLCAFVDADIRPENVTLDDARSFARFGNAVASLCVRRRGAIPAMPTLDEVEKVLS
>NZ_CP012069|44499:169886|136895_137897_+|WP_050342589.1|transposase|DBSCAN-SWA
MVLTRRRGSFADLEASGQRRRTRRERFLEQMEAIVPWREWVALIESHYPDGRRGRRPVGRGRMPGTCLLQVWFHLSDEACEDAVLDSRATRRFVGIDMMSEQVPDATTLPEFRHLLEGEGLGEGMLAELVSILDERGIIMRGGSIVDATFVESPSSTKNRERSRDPEAHQAKKGNNWHFGYKAHAGVDAGTGLAHTVEVTAANVSDVAVAPSLLRPDDEFCYAGAGHAGARGRQQAPGHPDPSEVTWRIARRRSRVPGRDHPEVSWERGIESSLSRVRSKVEHPFHVIKDLFGLRRTRYRGLEKNRNQLCVAFALADLALLAQAGRTLAPTCA
>NZ_CP012069|44499:169886|91029_91995_-|WP_050342510.1|DBSCAN-SWA
MSTVGTYTKPWLSFEQQADLLINERGLVADRDDLIRHLADIGYYRLSGYWYIFKRQPKGDKDGMQDERFIEGTSFDQIWRLYIFDRQFRLVVLDAIERVEVYFRTQLAYELARETGAFGFLDANNLPRLKQGKYNKFIARCKDELRRSREPFALHFKEAYSDEHELPPYWILVNLMDFGTMLRLFNGAPAEIRNKLANDLGVSSRVLESWLVTINTVRNICAHHGRLWNRGIGTRPIIPKRSKHPEWHEPFSVRSDNMFGILTILSYLLEHIAPETFWRERLFKLLGRLSFGELRRMGFTKGWQECPLWKPYAHNIEDAKE
>NZ_CP012069|44499:169886|52919_54368_-|WP_050342451.1|DBSCAN-SWA
MNLGMEDERTEHKRSTGEMREGMESIASILNKHGHGTLYFGVRNDGEVVGQDVSDKTLRDVSQAVGNRIEPRIYPQIERLETPDSRAYVKVTFSGGERPYACDGRYRIRSADEDVPMSASALKDMILERAAGRDPWDGRSSGKPVSAVDEEVLRRYVARGVQAKRIPFQYTDARDVLSRLGLLCEDETLTNAAMVCFTDRSQVGLRMGVLADSDRVNILDNQQVSGPLFSLVDAGETYIVNNIRRAFVIDASVSLQRREVPEIPLDAIREALYNAFSHRVYETNAAVQIDIFWDSVDIYSPGPFPPGVLPDDFLAGRSAASNPRNVLIAQTLYRSGDIESYGTGLQRIRRSCEAQGTPVEVFERASSVHVKFTRQEALDGVGRLGPFAGDTGNPPKSAGIRRNPPESAGNDRASDWLALPTSDRSVCEYLSAHGPSSPREISAALNIPVRTLRDIAGRLEASGLISSSGTTKNRTYELWKRG
>NZ_CP012069|44499:169886|149138_149795_+|WP_083443706.1|DBSCAN-SWA
MSDGFVDPYIDLRTGVLRNLVGAGTWDELRNAEGELVAMRMSEFLRELPLEPTGTLDDLRCIHRWLFRDVYDWAGEVRTIEIRKAGEGAQFFLPSANIPMGIAWARSELEKDDFLVGLASRRFPSRMAYHYDNYNFVHPFREGNGRTQRLLWTLICHHAGYDLDWRDVTGAENDEASRLAAEDRDMGALVSIFARIAAPCDPSVPINAGLVQAGHLGG
>NZ_CP012069|44499:169886|132806_133724_+|WP_050342585.1|DBSCAN-SWA
MKKVIVFGSLNMDLTIEADRVPYGGETLPGRNFLSNPGGKGANQAVAVSKAGVRTHLVGSVGADVFGDLLLARVASYGVQCDEVILREGVGTGIAMICRVDGDNRILLSAGANHSLSAADVKEALDRLAEPGDVFLTQMECDYATTCAAIQDAHGRGMYVVVNVAPPRDLPQDVWSCIDLVCVNETECAAICGVLPEDDGTLRQALDLLIKRGVGCAVVTLGAGGSAAREGTRLYRAPAARVNAVDTTASGDTYLGVLCAAYVNGMPMEDAMRRASAAAGITASRVGAQRAIPTAAEVDAFMREA
>NZ_CP012069|44499:169886|116645_117635_-|WP_172674414.1|integrase|DBSCAN-SWA
MLLPIPLLSLALVLRKRRSTPDVSGWMHDMSADSYAPKSCSKAFRLFKQALKWAVAQDLIAKNPYDFCKPPKRVKTPINALSREERTRMLRLAMQAEPQPLGFTVEIALTTGMRRGEVCALRWSDLSDDGTITVSHALGNGPGGFYVKEPKTGSSVRTIPLTKHLNTMLSARRRDAERVAREMGVSLGDPYILGTQEEKSRPYNPTQLGKDFAAFCKMNGFSCTFHDLRHTFATMMIAGGCDVRTVASYLGHASVSMTLDIYADVDPDAKRAAVDKVADSFDVDLDSLYDFPSPATAPSVSAVALTFSVDQLKAMLAAAEEKEAGHEHL
>NZ_CP012069|44499:169886|159722_160394_-|WP_050342628.1|DBSCAN-SWA
MISVMVVDDQRYERLGLALMLKGAEGIRIVAQAENGREAVDALAAASGDEMPDVVLMDVRMPMMDGIDATRIITRAHPGVKVLVLTTYDQDDYALGGLSAGASGFLLKDVTSAELADAVRAVASGDAVLTPRITRKVLGRCFPSSPLASPRGSAPMHKGSFSSLTPREAEVASLVADGFSNAEIAERLVVEPASVRRYVSRILAKTGLRDRVQVAVAWVRAKM
>NZ_CP012069|44499:169886|161668_162400_-|WP_083443707.1|DBSCAN-SWA
MERIIEAYGLSKASLTKGAPPILDNCSISIGPGMTAVVGPSGAGKTSLLYALSGLDVPDTGQMLAFGQDVYALPDGQRTRFLRERVGFVFQDYNLVPYLTVKENALLPLSPAGHRGDPAQLAALLNRFGLSGHHAARAQELSGGERQRCALIRALMLSPKVLFADEPTGALDTGSSHVVLATLKEMASTGCAVVVVTHDPNVASAADVIIFMRDGRITHVAGSMAPKEILDGMKEHESEADHA
>NZ_CP012069|44499:169886|62492_63737_+|WP_050342472.1|DBSCAN-SWA
MDNGIDMGIVWWQVYPLGFCGASVRPTSEGERTLTPRLDRLGAWLDYAVDMGVGGLMLNPLFASETHGYDTTDYFRIDPRLGDDASFDRLVAACHERGLRVMLDGVFNHVGRSHPLFQDALAGRGNEDLFSITRRPDGSADYATFEGFRELPALNHDSGRVAGLVRDVMLHWMRRGVSAWRLDAAYAVPPAFWACVLPELRNTFPDAWFVGEVIHGDYASIVRQSGMDAVTQYELWKAVWSSLKDGNFFELDWCLKRHNGLMRTFVPLTFIGNHDVTRIASMVGSELAALGATILLTVGGVPSVYYGDEQALRGTKRKGLGGDDAVRPTFPASPAWMTAEGERTYRLYHDLIDLRRRNPWLARATTRPTRLANRSYSYDASGRGGEALHVDLRLDPTPHATISLRGKVILEVGH
>NZ_CP012069|44499:169886|150354_150981_+|WP_083444065.1|DBSCAN-SWA
MACLRWEDIVTHPRRTHAWEQRKLGELGVTYGGLTGKSKEDFGHGDARFVPYTNVFDNPIADSTRLGEVEIDVSQNRVLHGDTLFTVSSETPNEVGMSSVWLSDLDNLYLNSFCFGYRQDGSFDPYYLAYMLRSQSVRENIELLAQGISRFNISKGKVMEVEVPVPMMAEQRAVGALFSRLDSLIALHQRKPDALKTVIKSLLDNILV
>NZ_CP012069|44499:169886|164273_165497_+|WP_050342635.1|DBSCAN-SWA
MKAFHFFLTRIFLRKPIFAIGTLTLLFLANYIVFSTARTVFSAREGYEQMARINAEGTFMASLDPDATVDVDSSSKESIQSVYDVLDDRYEYAFYTDGYITDLANSHGVEVPVGYMNQRYNELNGFSVAKGDGLTFDYSLDQGEAIPVLVGRGLADDYPLGSQFTMHDPALGRELTVRVVGIIAENSSHSILYAPDLKQYHNFSVVIPVNRAFIEQADAFLKLNGLMDLILVNTDRTGVSELGAYVNRTIGVKFNYYSRQDNIEFYNQYLVSSTSSLLVVSGALLVLTIVLSVWGSLASVRVMVRDFTINVLVGLSYSKVRRLLFSYYAGLSLLTLLAVLAMAAYSRYDAWQGKSAFLMTYGCAGLIGMDWLALLVALLLDLFLVTVVVQTISWRLRRVPISVGVLQ
>NZ_CP012069|44499:169886|79015_79831_+|WP_050342497.1|DBSCAN-SWA
MLSWLRDLFGIKRAELPGDDPVRSRVPLAESRILVVPSGYNVRELGGYPTPYGQTLYHRFLRSGDTDELNGADIAALRDYGVSMDVDLRSQWEVTHSPDRLAKDRGVRSLHAQLHSYDMHAHDLKLPDDTEGYMANGYLSMLENRKVVRKIFSFMAKAADDECVLFHCAAGMDRTGVTSMLVLGLCEASREDILRDYLYSFADADRVEELLEGKDSARSDFDGPMGADMLMHTMSAVYQALLDGCGSVRGYLLSCGLGEDELDRVRHHLVG
>NZ_CP012069|44499:169886|125200_125761_+|WP_050344655.1|DBSCAN-SWA
MQAIVDLAQESGGMMTTTQVVEAGIPRARISDMVKAGKLERVQRGVYYLADTWKDEFLAAQLRFFKGALSDGTVLFLHGYTDRTPLQLTITFPCSCRATKAREAGIEVRTCADGVLDLGRTSVRTSYGNEVRAYDLKRTLCDVVCGQRIVDVQVVSPAMRQYARSGSKDVQRLLGYAHALEVKKKI
>NZ_CP012069|44499:169886|156182_157115_-|WP_050342624.1|integrase|DBSCAN-SWA
MLNELTSSDLFHTYYKEWIAVYKEDAVRQVTLNKYKLALGWIERLAPDLTLENLDRLAYQRILNEYAKEHERQTTMDFCHLLKGAVLDAVDEGLVPRDPTRKAIIKGKAPRPKKSRYLNQFELHKLLAGLNLGQKISWEWFILLVAKTGLRFSEALAITPVDFDFTKQTLSVSKTWDYKNGGGFVPTKNRSSVRKVQIDWQLIVQFSVLIKDLPESEPMFVKQGKKVYNSTANNVLARLCKEAGVPVIPIHGLRHTHASLLLFAGVSIASVAKRLGHASMNTTEKTYLHIIQELENKDVDLVMRSLTSLI
>NZ_CP012069|44499:169886|157913_159371_-|WP_157051327.1|DBSCAN-SWA
MLEKNDRKGTMFVAREGELTALERMYKRDGFQMAVIYGRRRVGKTTLIDEFVKDKRVLYFTAQQKTSHQNLELLSAATYAAFSLPATLPAFASWNDALRFVVERVGKEPPDTPLVIVFDEFPYAAEANPSLPSALQTTIDHGLKQTDTKLILCGSNEGFMESRVLGSKSPLYGRRTMQMRLNPFDYLDAARMLPGVPPEELVIYYATFGGTPYYLSQVDLSRTYEENVRELFFDRLGLLYEEPLMLLRQELHEPARYNSILDAVGSGNSTPSRIAKRAGVNPNSVGKYLKTLSVLGIIEKVSPLGNGPTSKNSAYRLKDPLFAYWYRFVSRYLGTIEKGAGAAASAYASSGQALSTYVGKQFKDVCLQWVQRESIAGRLPFSALEFGQWWGTDPDAHEETDIDIVAMNRVERELLVGECRWRNSFNETAAIKTLEHRSTLLKGFSRRHFVLFTKRETSAATRRAAADRADLCLVTLDELYAGLNP
>NZ_CP012069|44499:169886|101979_102654_+|WP_172674409.1|DBSCAN-SWA
MKVAALLAVNVAAVLNRSFSVEIAVMACIVAALLYSRLNRTAIRCAATYAAAVIIMAFAGGENGIASVLLVVAMVIRKTTPIFGFGYCLVATTKISELLVVMQKLRLPNSITIPFSVVLSYFPSLASEWRNVTGAMKMRGFGVSPKNVAFHLVRTMEYVMVPIIVRSATVAEEISAAAITRGIEAQDVRTTVYPMEIDLADAICLVACTCLVAAAVASRVGAIA
>NZ_CP012069|44499:169886|125781_126177_+|WP_050342564.1|DBSCAN-SWA
MRTKNAIQLKAIIRNRAKVEGVLSQLVMQSYLFERLLERISLSTWRDNIVIKGGVLISSLVGVGKRSTKDLGTTVRGFPLSPENVEKTFREIVDVKADNDFSLSSSCALRTYARPTTTLASGSTCWRTTRR
>NZ_CP012069|44499:169886|51705_52485_+|WP_050344639.1|protease|DBSCAN-SWA
MVVAAVISFGAPVVALVVARRRLHVQFRAVLVGVLVFVVFAGFLEQLVHALAFSAFPGLRFTPVAFVPYAALAAGVFEELGRSCGFMLLLRSGKADHDLPCAIGYGIGHGGIEAMLIVGLSMVSNIALALALNSVGGADALLATVPDASRVLVAQQIDALIGIAPTVYLIAGFERIVSMALHVALSVLVWMAVSGRIGKAWIFGAVLLHALADGGAALYQQGMMLLPVSELWALIATVATALLVIRLYAGHGCHSDGTA
>NZ_CP012069|44499:169886|166313_166928_+|WP_050342637.1|DBSCAN-SWA
MGWWNPKAKIPIESEEFGKIVRDLVFECPSSHRHEVSDGKRPDGKKSKSRFYQSVSARNTSFHARGISGDLFLTILGEITGPLKRKDRYIKVENGQTVEEVAASAVKRLGSDAMKRDLLVFAPRSDMPDTEAIFYYIRNAFAHGSFEVQDVDCRRMYLLESDKKGKPLAMMRLSEQTLLRYAQLAHLSVKEIKNLRQGKRKRPE
>NZ_CP012069|44499:169886|98303_100094_+|WP_050342524.1|DBSCAN-SWA
MDKKGTVRRLFVLMGGYRWLEIVSMATVAASAAMNLLAYVRVYYVGEAVLTTAGDLSSIDRQAIAALGWDAVLFIMAAFGIYGIGLLFSHLTAFNTVARLRDRIVCHLGRVPLGYHVANPSGKLRKIIEKNTDNIENTIAHTMPDFVNAIALPVAYIACMFAFDWRLSLACLAPLVAGFFVLAWMLNDSSKSFYAKQQKSAEDMASATTEYVRGIAVVKVFGQTAESFKRYHDSVEEHRSWMLKYALSMRLPDSLYTVTINAGFLFLIPTAIVLHDSAKGGAAATTAAATFIFFCVLIPMTVTMLTRIMNAASNLMVSSASLDAVDDILTQPVLERPLAPKEPECFDIALDHVSFRYKPDSPLALDDVTLRIPAGAVCALVGQSGGGKTTVANLIARFWDVQEGTVRIGGDDVREMDYAWLAAHTSIVFQDTRLFKASIADNVAYAKPTASREEVLRALHLAQCDDILQKFPNGADAVVGARGVYLSGGEMQRIALARAMLKDAPIVLLDEATAYSDAENEHLIQQALSKLLRGKTVLMVAHRLSTVVDADQICVVENGRIVERGVHDELIAQAGFYARMYKEYERSVEWKIGGAA
>NZ_CP012069|44499:169886|104980_105625_+|WP_050342532.1|DBSCAN-SWA
MAKRAEGTTEKLLASARREFSRHGFANASLRTIALDSGVTTHTVYTRFDNKEGLFAALVGPAAGKFMETLMAGYDRYFDMGNESIRERELFSHSVYEELVDLMFDNRDAFMLLLDASAGTAFEHYVEKVAEQPCRRIYAQSDVLGMPLDDDQRLLVHVLTRGFFDGMFETLRHGLDRRSAQAFVSELISFYEGGLAKASLGQAAGFGGLVKELG
>NZ_CP012069|44499:169886|131468_132047_+|WP_157051324.1|DBSCAN-SWA
MDSTAMGISTPLGVVGLWLDGRPYAHDGLWEVVDRSDYATWHPVDGNVRIAHWHEPDGAAHTLACRLDPSHGCEGGFASGERLEATEIDDGRSRLVIAVEYDFEDYAQGHGEYEYDYQATAADLAATVELPADAKPQWIVFGVSWVEEVDDENGTNPWLVGDPNGDRLRMPMGSCTRNGSGMAAGPSTGSCR
>NZ_CP012069|44499:169886|163800_164277_+|WP_050342634.1|DBSCAN-SWA
MSWSARRSLVSHFVEKSLLRPKSRLELGALYVGCFLLASFLACVERQAAGSDVLLRYFEFMLHNKRAFVLGFSVVALVFHYHLLASSGTEIRCRVLVGDRLTLIRLRYIIECLALLGICCALSIALHLLLGFEIVDNLCLFAVLSMYILASAGLMGAR
>NZ_CP012069|44499:169886|76068_76842_+|WP_050342495.1|DBSCAN-SWA
MGTGDGVAPPEGWGLEVWRHGDACGEGDWGPGEDGPPLAGIGPGHLRLTFYYGGRVHEGTRGSLYEWISASLRAAGAAAAGLWRYELRYGSGTRIDAFGLWGTMWKSMGPGRAAALARASSLGWEGGEEASVRVKGRELRCGISRERFAALSGRGVEYLGPVGMDWSGELAADLLFALSDTWSPQLWRYVRGRDRLCGQVCERGGIAVGRSGDDTGLAAYLTVWEEGPMHGLLLRAAEVAPRLRPGSPRERWNEMFP
>NZ_CP012069|44499:169886|118471_120088_-|WP_050340583.1|transposase|DBSCAN-SWA
MPFIKVQKLVRDESGAIRSGSAAVVDTSYVRGAKYHSAQAVRERLGKVVWLADDRRSGVFASPTRGLVEYDADADGFAPVAKGDERLANTGAFPEPPRHLELGPEHLLLSFLGADGVAGCLREALPDDRSYQRALAHVTHGVVRDGSRETCDNMVARSFAALALPGVPPASLRSDTAFFSAMGADGAKVAFFRAFARLMRRTKPGFGRACYVDSTPLPNDAVDNPLNALCSHGLRGAAVQMRLALVLDETTGLPVWYEVVPGNVLDLSTIKTVMGDVLATLGIEVVTAVLDAGYASRELLEAFSEGERDVLVRMPARRGYPYRELWRGVRSLIGKGKYAITRSGHLYFARRRDVEVQGVRLHCYVYVDQTNATPRFARWLDKNQERFDGMSLAEKDWETVRQGYFVLMSTKVATPREILDEYFCRTEIEGVFKTSKDYLGLLPLRKWSDLTVRGKILADIIGTIVVLRMRKALAGADVSLTEVWGKARSLSCYTNADGRVVVETPSRQVREYYKALGVKVPSSIDVREFDRDVLGLEL
>NZ_CP012069|44499:169886|144238_145147_+|WP_050342611.1|DBSCAN-SWA
MIKLTTMTVQLIDCRPDGIRICHVEGESLITVVVPRDLLSKAKQLPDIPKRGIYYLLDEGHGVISRVYAGQTTQGLRRLDAHKSAKDFWNTSVMFLDDEVNIDRDVLDALEANAIDYVRKHGSYETDNSDTPQPYVSPYKEQTVQSLHRSILFRMAALGYDLNRIEDVPPRPRANCARRHDGPGYDLNRIEDVHSSEDKLFHTRKKGVVATGRYDERADTFVVLAGSQVDLSRPVLKSSIAADRRCELFGDAEGICLLGNNQSFNSPSAAAVFVLGGSQNGWIEWINDQGQTLDYVYRRKKD
>NZ_CP012069|44499:169886|65800_66976_-|WP_050342476.1|protease|DBSCAN-SWA
MADRAIIYFGPRTGFDELVGSRVREGDRTVGYLDAIRSYNAKIRASDLASHEPRISVPDYVDNCVVHADDFGSVLSHVIANFATILEETYEVGTLFVQNPPRRALESLVSAQGKDSVEQISYRYEQVEKGALEAIYDNVCEEVLGQEESKRVLVASLYRLSVMGNGRPSVVLLYGPSGVGKTETARCLSKALGGKLMRIQFSMMQTQEAYEYLFGAEHSKASLARDLLGRESNVVLIDEFDKVGPTLYNMFYQLFDEGRYIDTNYDVDMRGGLFLLTTNFKSERDARRAMGSAMFSRISACVAFSNLSDENKATIATRHYQRVVDRLDGEDRSLIENSGILSWFVAHASRYDNMRTMKNKIEKAIFERLSEPIFNRQATAPSVRRNPLREV
>NZ_CP012069|44499:169886|80969_82430_-|WP_050342499.1|DBSCAN-SWA
MSKQFWNPSFHIEPRQGWLNDPNGLCQFRGRYHAYYQYAPNWPTDELKYWGHVVSDDLISWEDLGVALAPDIQLDRSGVFSGCTWVDKGGAPDGGDLMRVFYTGNVVDTFDDERVDWGREANQIMTTSENGLHFSPKKALLTNADYPTSCTLHVRDPTVWEQDGCLHMLLGARQRGPADTDNPDARGDFGSVLVYDSHDKGESWQLRRTILPKNTAVAHLVFGYMWECPNVIRMGDREFLAVCPQGLPSESYRWQNLWQAGYFPLPAHKKIIDIDAVPLDNFTEWDHGFDFYAPQIFTDEGGRTISIGWMGTFDHSYTSVPEGMDRAHTMTLPREISLGQDGLLRQHPVAELDNYRGEARVLPCGESLVLDSLAADVVLEQIEDGDAQIWLNDVLEVFAENGSFGIRFAQTEAGELASAGRRTRGIRLASLDDLRMIVDGSTIEVYANGGAEVFSTRWFPISDKLTIRSSFRARSSFVYPLIKPTR
>NZ_CP012069|44499:169886|102650_104126_+|WP_050342528.1|DBSCAN-SWA
MIEISNLGFSYEGGNGACLQDVSLSVKSGEVVVVTGKSGSGKTTLIRALNGLIPHYYEGYMTGSVSVGGQALSSLPMPAIARMVGSVFQNPRSQFFNTDTVTEIAFGLENLGMPTEEIRRRVERAVVDLDIETLMGKSVFELSGGEKQIVAIAAAYALGPDVFVMDEPSANLDFDATRRLGRLVERLKECGKTVVVSEHRVYYLKDAVDRCVYLQDGRVSHEFSRDGYLALSSGDQAALGLRSLDLSLVEAQVATAQPEHDSQTGAPLRVEGLRGGYRRRETLRGVDIEVLAGRTVCLLGKNGAGKSTLASMLCGLVRERAGLVSVGRELSFRRRAGRFFLIMQDAGSQLFSDTVAGELAMSDAKGSLTVKATAALLEELGLGGTLSRHPLSLSGGEKQRLAIATAIVAEPDVVILDEPTSGLDFANMQRIAQAIRRLARRGTRVLIITHDYEFICRMADDIAMLESGRVTCTYPLDTEHAALLRAWFSIG
>NZ_CP012069|44499:169886|132074_132803_+|WP_050342581.1|DBSCAN-SWA
MAIFDGCEIVEHTNAEESYGRLCDEEIVVDVANPRCGEAIWMGFGNEYAVGIDGWHVHYDSCEVDYRQLKDDIAAILSGEMCFLAAFAGDGGFGLSSGRVMEKIGRTPSIFLAGSLQCIGFLVSSLLIEAGMVPFTLGICLFYAGQGLMFSPITTMVLGTLSASQAGRGIGTNDLVMNVSGSIGITIFGSIMGTTALSGLSLIGAAGKTATYSNLLLIYAATMMLGIIAFACFRKAINPKER
>NZ_CP012069|44499:169886|100069_101857_+|WP_083443694.1|DBSCAN-SWA
MEDRRGRMMGNPLQKALRVSDEGNANLLRASAWMCAFRLAAFLPVILLAMIANEMVVRSAGANAQDVPLLPYLGAAAALVVVMFLAYWVSYKSKYLSAGDEDARMRIALAERIRRLPMSYLGKRDLSDFTSAVMDDVDTVQGVLATSFVELVSGLLFALASIVCLLVVDWRMTLALAACLPLAALFMALSRLISEGQNRRNRARRLQMSEAMQEYLENMQELHALNLMNGYQGKIRRASRKLVPGLVLYELLAGLGISFGENFLRCGMGVVIVYGAARMASGDLGTFEFLLFLFASVRLYEPLCVAIERLGAIIHALVASQRIGEILDHPVQEGDGDVHPRAYDLEFDHVTFAYGEDDVIHDASFTAPQGQTTALVGPSGCGKSTLCRLAARFWDVDRGTVRMGGIDIGGIDPETLLRSYAFVFQDVVLFDDTIANNIRIGRAGATDEEVREAARAACCDEFVEKLPHGYETIVGENGRTLSGGQRQRISIARALLKDAPIVLLDEATASVDPENETHIQQALGALVKNKTVLVVAHRLRSIAGCDHIVVLQEGTVVEEGVHEQLMGAKGLYSRLFALQTKSASWSAGRDGNDVR
>NZ_CP012069|44499:169886|69097_69391_-|WP_050342480.1|DBSCAN-SWA
MHGAERGRNAMETLVRLDYGYSDTMGEPGYPGGHTPGNWREEYEATGEGSVAKTNREPRFVEEQRRKAVEHCPGHGRRSEIVCPRYRRGRRRFILTD
>NZ_CP012069|44499:169886|123924_124341_-|WP_050342562.1|DBSCAN-SWA
MEQSSITLTVLFDAPFWVGIFERVEGGELAVAKVTFGAEPSDPEVLDFVLGHFCDLKFSPPVAAEAHRVAESPKRRQRAARRQVRESGIGTRSQRALQAQLEAAKSERKREGKELREAEERRKFDLRQAKRREKRRGH
>NZ_CP012069|44499:169886|47346_47691_+|WP_050342436.1|DBSCAN-SWA
MRQYFMESALAEKLETVVTRGIANTRGRDYYDIHILVRLKSEEVDRQPLHEAVVATTSSEARSRRWLATQRHSRRSEYRESCEAWTSYIVGSPYAAGPDFDEIVGSTFESCSSS
>NZ_CP012069|44499:169886|61715_62315_-|WP_050342471.1|DBSCAN-SWA
MGNETNSRDAILRCALGLFSRRGYDGVGVAQVAEAAGVTKPTLYYFFHSKEGLLSAVLEERYAAFNRALGAACAYEPHPHEYGRDVRPALLRVARLYYSAAQEDSEFYLLRLSLSFAPPDSAVARMAKPYAHEQYAIVTRLFRGIATFHGGVRGRELSCAAHFVAMLNADVAFWHQGKGRLDDEQAKATVRQFMHGIFS
>NZ_CP012069|44499:169886|59231_59708_-|WP_050342466.1|DBSCAN-SWA
MNPLIVYYSYSGITKGLAEDIALITDGDLREIEPEEPYSFSYNTAVKEVRAQIEKGYCPPLRRGVESVGDAETIFIGSPNWLRTFAPPVLSFLRSVDLSGKTIIPFCTHGGGGFGHMLEDYRRECATSDVREGIALKGGYSFDELQGWLEANARSLAT
>NZ_CP012069|44499:169886|64353_65712_-|WP_050342475.1|DBSCAN-SWA
MNRTVAWIFRVVNALVVCALVACVCVPTIAPAPALAILGCWVLAICIRPAPYGERTRQPRIRSCRNACELLIVFLASTALLIVAGCLALCWPAPGGVPNVPQEPAFWVMCLGVALATETLVFWCGMVRAYARSVQLGLRLRVLGGIFGMVPLVHLHFLLKIISTLDAEARFEYERERLNEGRRQQRVCATRYPILLVHGVFFRDFKLVNYWGRIPAELERNGARLFYGEHSSALPVHESARELSLRIREVCEQTGTEKVNLIGHSKGGLDCRVALADPQVKAHVASLTTINTPHRGCEFADYLLNVMSNEQQQAIARSYNAAAHALGDPAPNFIAAVGDLTASGTTLLNRELPQTVEGVWCASVGSRLNGAASGTFPLNLTYLLAKCFDGPNDGLVGERSFAWGDSYRFLTVEGRRGISHGDVVDLNRENIPGFDVREFYVQLVADLKTRGL
>NZ_CP012069|44499:169886|117651_117963_-|WP_157051322.1|DBSCAN-SWA
MLARIVLWVIFAVCAAMTVAFLSGHGANLIAGYNTATEAEKETVNERKLLRVMGGGMLVATLVIFVLALLGGAAPIVLVCVSTAVIAVDSVAMVYLANTKCKK
>NZ_CP012069|44499:169886|69476_69638_-|WP_062393035.1|DBSCAN-SWA
MKKYVCGPCGYVYDPAVGDPDSGIAAGTPFEALPDDWVCPLCGAAKSDFEEEA
>NZ_CP012069|44499:169886|56792_57089_+|WP_050342460.1|DBSCAN-SWA
MSVDGDVARMSIVCIGLALGTLEWFIVRRTSFNKWVVPAVYWVGALIWSSATGPTPVLFPSLAMGLSMAGCAIEDEIINRYLQRRGTSGVDKARLRDL
>NZ_CP012069|44499:169886|87697_88681_-|WP_050342508.1|DBSCAN-SWA
MDITTVAKMAGVSRATVSRYLNDGYVSSEKRRAIARVIKETGYIPSRQAKQLRTGKTNLVGVIIPKINSASISRMVEGLTSQLNDSQYQILLANTDNDEKLEVDYLRLFAEKNHVDGVILVGTVLTSAHERAMDELRVPLVVLGQDIEGRSCVYNDDYHSIRDITALALDHATKPAYIGVTERDLAAGRARHRGFLDACEEYGLEVSASAQLIADFTVESGYLSCERLIESHPDVDTIICASDSIAFGAMSCLREYGRSIPDDVQVTGTGDSELTLVVTPTLTTVHHHYKTAGKEAARMLVDAMGKTTRIPCEIRLGYEVLARGSIR
>NZ_CP012069|44499:169886|138744_139617_+|WP_157051325.1|DBSCAN-SWA
MNPSSQPQSFAPQTSIAAAQRDASTLQSAFQPQQVSGGGWAEGSSHVQVQATSLVNGAKATWSTPYAIVSLVGKVIAVIALLMPCVSSPLLTAQLSSGGSSLFSILSNYTQASELQDIARGEWSMWSLNGLANSVNSLVSSLNKAWEAYGSSLGSGYASGGSNLEPLASLITTLATIVTIVWALMIVALVFTIVRPFVKNGRPAAHERRSGIDTAILVVVGLLCLAWCGIVTSVNGIIMSTLSSTLSSYNLPTVTLPNFLEVPLWPWVAAIASLLMAFWPRLSRRMGLSA
>NZ_CP012069|44499:169886|104186_104825_+|WP_050342530.1|DBSCAN-SWA
MKENKDAGMPAQAVRTGGTGKKMSTKDYVTVGIFALLHTAVLFIVGAIGGLSAVGFPLFGLVGFVPGGIIFVYIVTKVPKRGAVFGLGAISALVNFLIGAYGPVPLFVLMAGIVGEVVVSAGRYKSFPLIVAGYVLFALLIWFGFMSPIAFSMEGYMDSAVKSYGVDYMATLAGCVQGPLLMAFGAATTVGAVAGTLLGRRLFAKHFSRIVG
>NZ_CP012069|44499:169886|92127_92787_-|WP_157051316.1|integrase|DBSCAN-SWA
MRRGEVCALRWSDRSDDGTITVSHALGNGPGGFYVKEPKTSSSLRTIPLTRRTFDMLRLVRADAVRIANEFALPFGDPYILGTQEEKSRPYNPTQLGKDFAAFCKMNGFKCTFHDLRHTFATMMIAGGCDVRTVASYLGHASVSMTLDIYADVDPEAKRAAVSKVEESFGAEMSGYGNAIMDSVIGTPKRREPALSFSVDQLKAMLAAAEEKEARHGRL
>NZ_CP012069|44499:169886|55503_55839_+|WP_050342455.1|DBSCAN-SWA
MPRREEAGALTEPTFYILLSLHRPTHGYAIMQDVRELTGGRVNIGAGTLYGAISSLTEKGWIRAAEGHADGGRASERRKAYVITEGGRRAFACEVERLESLVADARSVIEQ
>NZ_CP012069|44499:169886|44499_46116_+|WP_050340583.1|transposase|DBSCAN-SWA
MPFIKVQKLVRDESGAIRSGSAAVVDTSYVRGAKYHSAQAVRERLGKVVWLADDRRSGVFASPTRGLVEYDADADGFAPVAKGDERLANTGAFPEPPRHLELGPEHLLLSFLGADGVAGCLREALPDDRSYQRALAHVTHGVVRDGSRETCDNMVARSFAALALPGVPPASLRSDTAFFSAMGADGAKVAFFRAFARLMRRTKPGFGRACYVDSTPLPNDAVDNPLNALCSHGLRGAAVQMRLALVLDETTGLPVWYEVVPGNVLDLSTIKTVMGDVLATLGIEVVTAVLDAGYASRELLEAFSEGERDVLVRMPARRGYPYRELWRGVRSLIGKGKYAITRSGHLYFARRRDVEVQGVRLHCYVYVDQTNATPRFARWLDKNQERFDGMSLAEKDWETVRQGYFVLMSTKVATPREILDEYFCRTEIEGVFKTSKDYLGLLPLRKWSDLTVRGKILADIIGTIVVLRMRKALAGADVSLTEVWGKARSLSCYTNADGRVVVETPSRQVREYYKALGVKVPSSIDVREFDRDVLGLEL
>NZ_CP012069|44499:169886|93048_94404_+|WP_172674408.1|tail|DBSCAN-SWA
MAPLPGWHLGRGVNPHEPPKSLLLSTVPKTSGAESFEVGGTWETWPTITLVAEAGSAVSVGDGSSSVAVEGTFAAGDVVVIDMERQAVTVNGADATARVSLESDFFALVPGGKCLGLLGLFFSLRELGREVGLMAVPTLYLFDRWDERLGVLPTLGFMTHTEGLGGEDTLEFGCLVAPEKGDRLVWRDPDTGAWREHEVVRTDEETAGIAHVYAESSLCELLRDFVEEEQLVAKTVSQAMAVVAHTRWSLGTVSCDDSTKRGALLCHSNALAALRRVESVWDGELECSYEVSDGRISKRTVSLRMSATTEGVGFQHLSGMTTAKQCFVSRTDLESVYATFFDTSALTAGYQMFYGCQKLVGGTDRTVVGNLTAYSICKLGEGGVLTDPGNDTRQWFWGTVYADGYLEISASSDVTWSRGVAGRGRTAPRPSTSWPQGCRGRTRRTASPRSR
>NZ_CP012069|44499:169886|50207_50654_+|WP_050342442.1|DBSCAN-SWA
MSIRLITDGVMGRGDQPRIILLSASGTKSAIPSIALAMRPMPVAAPPVRAHAWAPKSLVTRLHEDALSMRSEIYPTGWGDILAHVLEPEQQERQVICPPFATQWVLGQRRRIPREDGRDNSHEAITPVVGKGPGDPLAYASQNRLSSS
>NZ_CP012069|44499:169886|126098_126665_+|WP_083443704.1|DBSCAN-SWA
MRTEDIRETDDYPGIRVHLLANYEKMSSLVTVDVTTGDKITPESVEYSYPLLFDDRSIAIMSYLLATTLAEKLEIAISRSVANTRPRDYYDLHTLWLTRRDEAKPDVLRDAVAAAAERRGSHAAMGNYREVMAQVASDDGTLGLWAAYARRYPYVGDMTLGEACGTVVRRWSSGRSATRAARPRAARP
>NZ_CP012069|44499:169886|75684_75948_+|WP_050344645.1|DBSCAN-SWA
MTEVGAGVYAGLRCADCAFSEFVLNEESGMFVGTCSRGYTLADPHVHVSPDRFFAKNPRALVPVTDPYGREYLRTRNICTRFAPREG
>NZ_CP012069|44499:169886|94412_94811_+|WP_157051318.1|DBSCAN-SWA
MATAGFTELNMNYWFYAYGDVTSFEGLGNLRLVSRMRHAFSSCTAVTELDLTGFDPSSLTDLFYAFAGCSALTTIYVDADWALPSGCTGNQCFYSCKSLVGGNGTARASGKTGMAYCVVDKDGQAGYLTAKA
>NZ_CP012069|44499:169886|120401_121691_-|WP_050342548.1|DBSCAN-SWA
MAGYKTFTSATDMGPYVSKLILELPEKVHTKFVDRQGFSVYVERNDAKTSEVVLAKEHHTDECAFPSKGYIPVLAAYASDGEGNPQTEGSSIALKLPEELLTKRIDGALTRGYIRPMSFRITQTKEIPSEGPGEAPLTGMVFDIDTGDVCPDLTGWDLTGSGIFDDIDMNYGFFTPDLITVNAARATRPFTPLPPVEKVPLLVWLHGAGEGQEPYRTVMGNRVTALSSPDIQEKLGGAAYILALSSPTYWMDSGSGEIADDNKSIYTKALKTLIDEFIEARPDIDHKRIYVGGLSNGGFMTMRLVADYPGFFAAGVPICAPWVASLATDGEMKSIAKTPLWFVQSADDPIVTADVHTLANYRRLKELGATDVHITCFDHIKDETGRYHDKFGQPQRYIGHFAWIPAYHDTVKTELDGTNVLVGGAPVTL
>NZ_CP012069|44499:169886|165496_166162_+|WP_050342636.1|DBSCAN-SWA
MDNVIDLKLEHKTYRKGSSSVTLLENFSLTVAEGEKLAIVGESGVGKSSLLNILGLIDRHYAGSYTLLGRSARELSDRESAAWRNQRIGFVLQESALISSLSIADNIKLPLLYARPPGSGRSGRFEEVVDTLDIGPILRKKPLECSGGERARAVFARAVIMSPQVILADEPTASLDAKNRSRIIGLLFGLNRDLGSTVVTVTHDADVASQHDRVVALQRKA
>NZ_CP012069|44499:169886|127317_127938_-|WP_157051323.1|DBSCAN-SWA
MFCTRFTGEHENDFADTAEYEGSLLALLRETQAFVKRHTAESWEKTPNSRIERRSHSERAVEETLVNALIHRSYLELGSEVHVDMYNDCMKVRSLGGKIGAPLSDDIIKNRVRSERRNPIIADVFNRMSLMERRGSGLREICTATASEDAYRPEFMPRLETGENWFTVTLYNMNYVEADTVGTQVGTPSCDIMPGISTSFFDALAC
>NZ_CP012069|44499:169886|145154_147728_+|WP_050342612.1|DBSCAN-SWA
MNKQQLAAKIWASANQMRSKIEASEYKDYILGFIFYKFLSDKEERFLAENDFDADAMSCVTEDDAEVLSFVRDNLGYFIAAGDLYSSWLDKGSDFDVSDVRDALSTFERLVRPSYKNVFDRVFETLETGLSKLGETSGAQTKAISALLQLIRSIPMDGRQGYDVLGYIYEYLISNFAANAGKKAGEFYTPHEVSVLISQIVASNLRDRVEIRIYDPTSGSGSLLINIGEAVARRLGSRDSIRYYAQELKENTYNLTRMNLVMRGISPDNIVCRCGDTLEDDWPWFEEGHPETYEPLFVDAVVSNPPYSQRWDPDGKENDPRFDGYGIAPTSKADYAFLLHDLHHLKPDGVMCIVLPHGVLFRGGEEERIRRALVENENIDAVIGLPANIFFGTGIPTIVMVLKKRRPTDDILIIDASKGFVKEGKSNRLRACDIRRIVDAYERRRDIERFCRAVPKQEVRDNGYNLNIPRYVDSSEPAETWDIYATMFGGLPISEVEALKLYWDALPNLCERLFEPAGGSTLRLRVDDIEAAVHDSTAVRAYLDAYERRFSDFEMWLFDKLVDEALLVDRASEEDVLAAEVFGRLEGVPLVDPYDAYQVLDDAWRQVSEDLEVLQTEEFDAAKRVDPNMVVKKKRGRDVEVQEGWRGHVLPFELVQQELLANDLADIRRMDERSLAIDAELSEALEGLSEDDKAALGGAVSDNGDAFVAGRLKACARELHADGDSEELARIVEKASKLFDEQKRLKRQSKQQAIALEAKTKEVIEGLSDEAVRNLLDAKWNRPIVDGLAALPRASVDALVERVRSLADKYSTTFSQVEKQIHDEERKLCDMLGELTGDEFDMAGIRELRALLGGDGR
>NZ_CP012069|44499:169886|110863_111052_-|WP_172674413.1|DBSCAN-SWA
MGGDGYALTKHLETTLSAKRRDTERVAYETGVARGDPCTPGTRGACPATQLGSARTSRPSAG
>NZ_CP012069|44499:169886|148960_149146_+|WP_050342615.1|DBSCAN-SWA
MDRKRVIDESIHSGEMEGAYVSAEFREDADEYVRGHIPIEELMRRTKRRWEPDREGKGPHV
>NZ_CP012069|44499:169886|140152_140446_+|WP_050342598.1|DBSCAN-SWA
MASKEDISGMPLSVKAVFLRPDELHTGALGVKSLIFCDNRLGLSHPEVRILGGVRTRPRGSRARPGGRSGCGEHLHVRPAEGAWSLSRCRRVVNESL
>NZ_CP012069|44499:169886|131000_131255_+|WP_050342575.1|DBSCAN-SWA
MTLPSARHQLSCDRPIKGLPTKGVIFYDRTTQGGIEEPLPDGRGAKTIFSDKTMITMREMSPSDGSLAVGSAILGSSDSGGIKR
>NZ_CP012069|44499:169886|143423_143651_+|WP_050342606.1|DBSCAN-SWA
MARFSKSREEHHAWSGRYATEAHDPPPRTGRAEREHVASWFGANPTIGSGAHSRQSGNSSAKVRYDRPQGAAPLP
>NZ_CP012069|44499:169886|109634_110867_-|WP_172674412.1|integrase|DBSCAN-SWA
MNGLSCAFHDLRHTLATMMIAGGRDVRTAASCLGHASASMTPDIHADVDPKAKRAAVDRVADSFDVDLGSLCDFPSPRCHIERWCRRPHLLGGAAQGHARLRRGEGGFPWTSLGSPGASRTGSSAPCLGGWDWMGFSDLQLISYGNGYNLYLFPLYFVCMKFKEYIASHQAFTTGDLYAIATRETARTLLRRALRSGEVERVRRGAYVSKTGKFLGEAPDPFLVAKTVDPEAIVSYHSALVAHGVAHNVGFECSFRSATVRSPFEYGGVRYVPFGAGGDPRVQTMRSRSYGAVRVTTREQTLIDCLMYPKRAGGAEEALRSCSAFPYLDLEALTEILGSAPAAAVARAGWLLEAKRGDWGIADETLSALEGRLRRGPSKLDPKSQENRGWSRRWRLYLPESEEEVLSWTS
>NZ_CP012069|44499:169886|123670_123928_+|WP_050342560.1|DBSCAN-SWA
MLCGLKKYHPKAIERRKSSPRLMVYDTALMTVVSGRSRELLLGDSELRGHLVKSAVGARLLALGLDLGFDVQWWREGNDEVDFVL
>NZ_CP012069|44499:169886|73380_73677_+|WP_050344641.1|DBSCAN-SWA
MDIAHTWTERLGDEDLEFARQFIMASGSLKEMASRYGVSYPTIRLRLDRLIQKIESVREDDDAFVSLVKGMAIDDRMDFETARQIIDAHRQLMGEKEG
>NZ_CP012069|44499:169886|71834_72209_-|WP_157051313.1|DBSCAN-SWA
MRYIVRNNISVPVVVVNYFFENFWRLGDTVNVGLHQPQVCSDACGHPRPSTDPLHILTQESEDLANRLTEAQTKLGASEEHGELFSNIREFFARYAKNVMDGMLSTQGLHRTTKGKGHYTIQVV
>NZ_CP012069|44499:169886|72245_72578_+|WP_050342488.1|DBSCAN-SWA
MPKREDSGALTEPTFYILLSLHKPTHGYAIMQDVRELTGGRVSIGAGTLYGAINSLTEKGWIRAAGDRASDRRKEYVITEGGRQAFAREVERLESLVADAKPVIERSLHA
>NZ_CP012069|44499:169886|73679_73976_+|WP_050342492.1|DBSCAN-SWA
MSVDGDVARMSIVCIGLALGTLEWFIVRRTSFNKWVVPAVYWVGALIWSSATGPTPVLFPSLAIGLSMAGCAIEDEIINGYLQRKGTSGVDKARLRDL
>NZ_CP012069|44499:169886|108718_109228_-|WP_172674411.1|DBSCAN-SWA
MRPGAMVRTLADAELAAGKVKAFFDRVKVRDLYDISNLKGVYETLEPGEQERVHRLALYYASLSACFPKPFEGREQRFADRLSELADQLYPMLRSSIEHPTLEALMEDAKRFVADWILPKTDREREYLERLAAGDYRPELVFQDESMAKAAAANPEALWKLENLRKMPR
>NZ_CP012069|44499:169886|142057_142300_+|WP_050342604.1|DBSCAN-SWA
MAEKPEWVKSFARPRGTEIKHIRGHWYLYERGSIYDPKIKRSRKKSGRCLGKITPEGLVASVSRKERAERARVAGFTAAG
>NZ_CP012069|44499:169886|50640_51183_-|WP_050342446.1|DBSCAN-SWA
MEYVALLRGINVGGKNKVIMDELRRQVEDMGCADVRSYINSGNVLFETDVPESEISRAFAAMLKERYPFPIRLAILSREDYLSEVPDLPTWWSEPIARRDVLFFTREIDAQHARRRIKSMPLGDEAIHFGRHVVFWGKFSESEYLRTAYHRLLMREDFYPLLTIRSGNTFDAIATLLTRS
>NZ_CP012069|44499:169886|115605_116541_-|WP_083443700.1|DBSCAN-SWA
MAAKEPARNESAIIASNDAQIRDMIYTVRGQQVMLDSDLAELYEVETGALNRAAKRNEDRFPEDFRFRLTDDEYENLRCQIGISSDDLQKFAAGGRRYMPYVYTEQGVAMLSGVLRSRVAIDASVRIMRAFVEMRHFIADNAHMFEQIRTVELRQLKYQKSTDERFERVFDYMETHEAPSQKVFFEGQVYDTFELLVSLVQRAKRKIVLIDGYVDTGTLNILAKKRQGVSVTVWTHPKTSLTKCDIETFNAQYSTLEIRHTASFHDRFLILDGIEGYLVGASLKDAGKKSFAVAKLEDSAVVGSIVAALDK
>NZ_CP012069|44499:169886|95501_96395_+|WP_083443693.1|DBSCAN-SWA
MNALDGVAGRAFSYGVGIGGAHWRRGDAGWRGGVELAMAARWSGRQCADYFAGTTRQASSNYCIGVDGDVVMSMDEDDRAWTSSSAWNDRRAITIECGNIDNSTGEMSQKTWDTLVGLCADICTRYGFRLNYTGDRNGSLTEHRMFASTACLGARLHARMGKLASEVNARLDGGSTKSDSKSGSSDVYLVKVTCDALNIRKGPGTGYAVVGCIRSRGTYTIVGTSGNWGRLKSGAGWICLDYTSRAGSAKASSAKAADIDAMARAVIRGDYGSGEERRCRLGEKYAAVQRRVNELLK
>NZ_CP012069|44499:169886|150992_152474_+|WP_050342621.1|DBSCAN-SWA
MENQDIEYKAVWRDEYLQWLCGFANARGGTIYVGIADDGEVVGVKNADRLLEDIPNKAIAALGIIPYVQLHRENGREFLEISIEPQDFPINCKGRYYLRSGATNQLLRGVGLDTFLLRRRGRTWDSVPVPNVRVQDLSRKAMDSFLGEARGGGRMPDDVAGDDAESLLQSLHLLEGGRCTNAAVLLFHPDPMAVFSSCFVKVGYFNGSEILFQDEVGGPIIGQVDKTLDLLYAKYLRARIDYDGAHRVERFPFPRAAVREAVVNAVVHRNYASTSPIQIRVCDDCLQIGNACILPEGWTVDDLLGFHESEPHNPKIAHVFFLAGLIERWGRGVQRIFSACKIDGVESPLYRMVGNSLQIVFTAPADRVMRIGVQQSDPGDVATHVHADDRDGAVLTRLGATWRDLARLGATYPDFGHRLMEAWDALSARDRGILGQLATDGPTRTADLSDSLGVSLRTVQRTMKKLAVIGLVSLQGKANESRYYLNIDSGKGE
>NZ_CP012069|44499:169886|82743_84261_-|WP_050342500.1|DBSCAN-SWA
MAIKRTWSPKHNWRLRFHLQTETGDITDPNGLCQLDDTYHYFHQHRRLWPDAAHGWGHWTTRDFVSWKWLGSPIMPDRELDKNGSYSGSATVHDGRMWCYYTGNQLLPGEHDYDYSGRLANETLVVSDGSTFGEKRLVLGNEGYPAYCSCHVRDPKVWKQGGCWHMLLGARAQGDRGCILLYKSPDGLSWRLEGSATNLGRQPFGYMWECPNLATLGRREFLFVCPQGVGKRPTSLQNIHNSGYVALDGRLIDLMAKDPGLMDADGPYPCIDEAGFVELDFGFDFYAPQVFEDERGRTILVGWASLPDIETQYDNPTREWTHTLTLPRELTLNEDGRVCQWPVTEIDALRGELVEFTSDVAGLTGTVGSSSYDVFDLTGAVGARFAGTADICVTQIESGDAVLRLNDDLELSVIGNLCELAFTSPAGAYRSVRRLPLSALTAGRIRNLRVIVDTSIVEIYVNGGEVTMTTRWYPESVDELRVSSSLKGRHQGWEMGSCHFAGIDS
>NZ_CP012069|44499:169886|74237_75197_+|WP_050342493.1|DBSCAN-SWA
MSFKKIAVAGGGVLGSQIAFQSAYCGLDVTIWLRMESSIGRSRPKIDRLRQIYLDTLEALKTDPAAYAYGLIAREDISPEALDACKERVEQAYASLRLTTNWDEAFSDADLVIEAVAETPDAKTAFYKELARHIPERTVIVTNSSTLLPSSFAETTGRPDKFLALHFANEIWRNPTGEVMGHAGTDPTHFEEIVEFASQIRMVPIRVLKEQPGYILNSLLVPLIAAALRLWATGVGTPEDIDKDWTISTGAPYGPFRLLDIIGLVTPLNIISRSPQAKDESSVEHKIVQMLQAKMDRGETGVNAGKGFYDYGGGEPAAK
>NZ_CP012069|44499:169886|160593_161676_-|WP_050342631.1|DBSCAN-SWA
MHRYAIRIFAEDLVGWVPLVCVVTMTSTLVGICVSQAVWTSGPAFAEATRAARLDLTGFQVVSVTIYAEVALIALFALTAIGSATVRRCHSTFAQWRLAGATPIQVRVSALSVAGLASAIGSAAGSLASLPLSSALVPAFDALAAEGFSGGLGSFEPPAFDVGALAAPLAFAVSWPTCMAGAILPALRTGRVAPVDFLRKTGADTGRSRAGTAARRVLSGLLLGLSLVIFVLGALLGGNGVGAIVNGIVSAGILATLAVFAAGVEGVRLATRAAGLIPRTLGDAVGHLAAREAIEEIERDSHAVVPLAAALGGGSALLCAARYLEEVLSRLGLPAELNYADVLVLFGLVGTRCASLPGGR
>NZ_CP012069|44499:169886|107887_108034_-|WP_172674410.1|DBSCAN-SWA
MASFMRHKEDSGTIEPSTVRGYRAETRIICRYLGSVRLAELSIPGTSF
>NZ_CP012069|44499:169886|141151_141646_-|WP_050342602.1|DBSCAN-SWA
MDMVKVGSFLQELRRQSNVTQEQLAERMGVARRTVSRWETGRNMPDLDILVELADFYEVDLREILNGERKGEHMNEELRETALQVAEYSGEEKLKITRRMHWLFLAGLASATVYLVLVLTNKADDFGGGLCLGIEFGTVIIGVIMTSRYAAKIREFKLRLLARQ
>NZ_CP012069|44499:169886|144032_144239_+|WP_050342608.1|DBSCAN-SWA
MKHSEFVDLGTSPAEAQALLMDFESVAVAMRMPRTLRDSPPKGSVTPDGMSITSAGMCLIDRLPREVC
>NZ_CP012069|44499:169886|121760_122306_-|WP_050342550.1|DBSCAN-SWA
MHLIESPDELEGLIQEANQNDRSYFVPAFTSLGAPRWDSGATDMLAGVTTLTGRAEIVKACTGCIPHQIADALNALRADTGLALETLRADGGVTKNAYLMQFQADMADTSVEASKLAELSAAGAAFAAGHAAGLWTTNAIHEWYGHETYTPQMADTVRQSKRSGRQVAFRQVRCHIADLSG
>NZ_CP012069|44499:169886|95195_95414_-|WP_050342518.1|DBSCAN-SWA
MPAVTMGLAEAKNNFSKVTAEVNRTGRPVTVLKNNRPWVVIQPAAGAAQTDAVDVAVDFMDEYADVFRELAK
>NZ_CP012069|44499:169886|47898_48048_+|WP_157051312.1|DBSCAN-SWA
MGATGTILPTIESTSCDRRAAKYHEGGVERALSDGEGGRGTVGRERGRL
>NZ_CP012069|44499:169886|48626_49169_+|WP_050342438.1|DBSCAN-SWA
MLYGYDDMLARYGSAYQIGKAVDSGAVFKIARGLYSDERHPDPNAVVCALYPQTVLTMDSAFYLHGLTDVVPEMVHVATARNSTRIKDARVRQYFMESALMVAGVEMTGDGGSTVRLFSRERMLVELLRCAGSMPLDYYKELIVSYRKIVGDLDMREVEDCMALYRRADSLFDMMQREVL
>NZ_CP012069|44499:169886|112287_113904_+|WP_050340583.1|transposase|DBSCAN-SWA
MPFIKVQKLVRDESGAIRSGSAAVVDTSYVRGAKYHSAQAVRERLGKVVWLADDRRSGVFASPTRGLVEYDADADGFAPVAKGDERLANTGAFPEPPRHLELGPEHLLLSFLGADGVAGCLREALPDDRSYQRALAHVTHGVVRDGSRETCDNMVARSFAALALPGVPPASLRSDTAFFSAMGADGAKVAFFRAFARLMRRTKPGFGRACYVDSTPLPNDAVDNPLNALCSHGLRGAAVQMRLALVLDETTGLPVWYEVVPGNVLDLSTIKTVMGDVLATLGIEVVTAVLDAGYASRELLEAFSEGERDVLVRMPARRGYPYRELWRGVRSLIGKGKYAITRSGHLYFARRRDVEVQGVRLHCYVYVDQTNATPRFARWLDKNQERFDGMSLAEKDWETVRQGYFVLMSTKVATPREILDEYFCRTEIEGVFKTSKDYLGLLPLRKWSDLTVRGKILADIIGTIVVLRMRKALAGADVSLTEVWGKARSLSCYTNADGRVVVETPSRQVREYYKALGVKVPSSIDVREFDRDVLGLEL
>NZ_CP012069|44499:169886|46581_47154_+|WP_050342434.1|DBSCAN-SWA
MTLETRRLVLRPWEEGDAEDLYRYASHPDVGPIAGWAVHASVEYSREIIRGVLSAPENYAVVLKETGRPVGSIGLMRGGASNISIPDTEGEIGYWIGVPYWGRGLIPEAVREMVRHGFEGLGLERIWCGYFEGNVKSRRVQEKCGFCYHHTAENVPCALEGVLRTEHITCLSREAWLSARGGPVPGGGEG
>NZ_CP012069|44499:169886|69676_70864_-|WP_050342482.1|DBSCAN-SWA
MRKHVKANVSWVGYIDWELEWFHGEDYSIKNGSSQNAYLIEEEKTALIDTVWLPHRFEFVENLEKEIDLHKIDLIVANHGECDHSGALVALMEKIPDTPIYCTANAVKSIEGQYGKRGWNFNVVKTGDSVDIGNGKRLVFVEMRMLHWPDSMATYLTGDNILFSNDAFGQHYAVEELFNDKADQCLLYREAMKYFTNILNPFSPILVKKLEEIGKLSLPIEMIAPSHGAIWREEPLQIVNKYEEWAAAYQEDQITVVYDTMWEGTAKLAHAIAAELHKQNPETVVKVFSLAKTDKNELMTEVFKSRAIAVGSPTVSNSYLSSVAGWLEFLKQLKFKNKKAAAFGCYGWSGESVKLLQEKLREAGFTVIEEHVRSQWNPEEADFATVPALAKALLS
>NZ_CP012069|44499:169886|105989_107606_+|WP_050340583.1|transposase|DBSCAN-SWA
MPFIKVQKLVRDESGAIRSGSAAVVDTSYVRGAKYHSAQAVRERLGKVVWLADDRRSGVFASPTRGLVEYDADADGFAPVAKGDERLANTGAFPEPPRHLELGPEHLLLSFLGADGVAGCLREALPDDRSYQRALAHVTHGVVRDGSRETCDNMVARSFAALALPGVPPASLRSDTAFFSAMGADGAKVAFFRAFARLMRRTKPGFGRACYVDSTPLPNDAVDNPLNALCSHGLRGAAVQMRLALVLDETTGLPVWYEVVPGNVLDLSTIKTVMGDVLATLGIEVVTAVLDAGYASRELLEAFSEGERDVLVRMPARRGYPYRELWRGVRSLIGKGKYAITRSGHLYFARRRDVEVQGVRLHCYVYVDQTNATPRFARWLDKNQERFDGMSLAEKDWETVRQGYFVLMSTKVATPREILDEYFCRTEIEGVFKTSKDYLGLLPLRKWSDLTVRGKILADIIGTIVVLRMRKALAGADVSLTEVWGKARSLSCYTNADGRVVVETPSRQVREYYKALGVKVPSSIDVREFDRDVLGLEL
>NZ_CP012069|44499:169886|49718_50138_-|WP_083443687.1|DBSCAN-SWA
MATRRLPMRHIRTGPATLPQASQGSASHPRATQDIRAHEYQVTDYEYIANTAQRAINGYTVPITPHLDHGKTLGDVRQAVNAGFTSTMIDGAALPFEENIRLSRQAVGRRRRPARAWPGRGHPHPPPHGRAGSTRRRRP
>NZ_CP012069|44499:169886|54364_54865_-|WP_050342453.1|DBSCAN-SWA
MRVVARGKRTPKSIKRLLDVWERSVRTTQLFLLHLGIKAILAYMPLALKSALRFVIAEEEAKRLWGFTDIDGHKLMMLFVVADERGKGVGSKLLEYGIAAHAISEFTVNGQSPQAIGPYKHRELTVRSRSDIDEQGDPRPVLLMGRDPTGTVPFVEYNRQWEGGRL
>NZ_CP012069|44499:169886|168419_169886_-|WP_050342640.1|transposase|DBSCAN-SWA
MGAYSVPEHIRAMKPRGTMVKAISGHYYVYEYRSVTEGGRRTRMGRCVGKIEEGRGYVPNSGRASGSEITTLEFGDWAVALSASAPVRGLLGEHFHADDADRIWALACMFCVRGVTPARDARRVWEQSALSLALPSVALGERAVGELLDALGRRQGPVLAFERALAEASSRLVAVDGHVVGSGSLPDDLAGKGYRFGATHCDQMNLLMAYDALGGSPLACRIVEGGLPGEASLADLVADVPLDGVLWLVDSGFHSAANVELLSSGNNDYIMPLHKGLRACKDAVAEMDLRERLGWARGRKATVVEWKEHDAGGGRRVLVLRDRDQAAVERANYLRYLAQGRKGYTEDGFASAEPFFGVCVLQTSLADATAEQVWDHYKRRWAIETYYDWLKNGMGLRGLCQRDYCRAQGLAFVCLVASLVRRELADLVGGRLPGRTVDEALLDARLVKAHLRAGRWGCCNCKGSVRRLFDTLGVPLEARFPIPAPAHT
>NZ_CP012069|44499:169886|72628_73189_+|WP_050342490.1|DBSCAN-SWA
MSTSTTIKRAFTDFSKEEAWLNEMSHEGKALVDYRGGRYTFVDDEPGTWQYAIEILGQGGKAGKEYLSFLEETGIETVAVYANRAYLRKRDDGTDFELHSDLESRLEQARRGSVPWIAIPVSQVGLAFILVLNAFVVDSEASNLARGIVLACATLLAFAAIIEYLVFGKPYRERVRQLERERSIRE
>NZ_CP012069|44499:169886|122911_123097_+|WP_050342556.1|DBSCAN-SWA
MFQRKIVEIIAARMWEDDNRPIQVVAGPRQTGKSTAIAQALEKVDKPAHSASADDVIAPDV
>NZ_CP012069|44499:169886|123130_123607_+|WP_050342558.1|DBSCAN-SWA
MQRDSDRPAILVLDEAQKVRGWPNAVKGLRDADQREGRPLKVVLSGSSSLLLRKGLEDSLKGRFEVLRSTHWGLAECREAFGFTLDDFLFFGGFPGAVRLVVDERRWRAYMRDSIIEPTISNDVLEQEDVREPALLRALFDLGARFSGQELSYNKMLG
>NZ_CP012069|44499:169886|55898_56459_+|WP_050342457.1|DBSCAN-SWA
MSASTTIKRAFTDFSKEEAWLNQMSHEGKALVDYRGGRYTFVDDEPGAWQYAIEVLGRTGRAGREYLSFLEETGVETVAVYANRAYLRRRDDGTDFELHSDLESRLEQARRGSVPWMAIPVSQVGVAFTLVLNAFVVDSGASNLARGIVLACATLLVFAAIVEYLVFGRPYRERVRQLERERSIRE
>NZ_CP012069|44499:169886|96823_97810_-|WP_050342522.1|DBSCAN-SWA
MADEKTGSGEGRDAIVPVVDARTRSMIHTVRGRQVMLDSDLAELYGVETKALNRAASRNSARFPEDFRFKLGHDEFESLRCQIGTSNNGDGRGGRRYMPYAYTEQGVSMLSAVLRSEAAVRVSVQIMRAFVEMRHFIADNAHMFEQVRNVERRQIEYQQKTDERFERVFDYMESHEAPRQKVFFEGQVWDAFELLVSLVQRAKKGVLLVDGYTDAGTLNILAKKNDGVSVTLWTHPKAKLTAKDIETFNAQYPELTVRRTESFHDRLIILDGTETYLVGASLKDAGKKVFGITRIEDSETVQTILVRLDPGEENADVKEGTEGQAAEG
>NZ_CP012069|44499:169886|140583_140901_+|WP_050342601.1|DBSCAN-SWA
MQCRALPGAARAPYVRLPLRYFTKKGIGEFDLVTERKDGAIIALEIKSGRGYKAHAAIDDALKIEHYHIDEAYVLAECHVGRDDTLLYLPVYSIGLMRNSWAGRG
>NZ_CP012069|44499:169886|109224_109647_-|WP_050342536.1|DBSCAN-SWA
MDIMSTGEFEPRTVDKVERLLDLLDEMERHPALKGKLALHGDTAINLFMLDVPRLSVDIDVSYIGSVSRKGMLADRPHVEDGIEAVAQAQGYAVEAHPGGHAGRTFLLRYRGDWGVGHVKVDCIYMNRSPILQPCCERRP
>NZ_CP012069|44499:169886|67731_68406_+|WP_050342478.1|DBSCAN-SWA
MQYNIIGGSFPVVTCSLADGESMVTEKGSMVWMTPNMQMATSGGGLGKMFSKAFSGESMFQNIYTARGAGMIAFGSSFPGKIVAVQIQPGHSWVLQKSAFLASEMGVELSIFFNKKLGAGFFGGEGFIMQRLSGSGVAFAEIDGDLVEYVLEAGQQMIVDTGYVAGFEESVSIDIQSVRGVKNVVFGGEGLFNTVLSGPGRIWLQTMPISGVAGAIIPYLPAKS
>NZ_CP012069|44499:169886|131290_131476_+|WP_050342577.1|DBSCAN-SWA
MANIDMRLPESDTSLLAGMIGKALGEFVYGERFESVPEEARKWHRVNREVVSPWERGESCG
>NZ_CP012069|44499:169886|88757_90677_-|WP_083443691.1|DBSCAN-SWA
MDLDLRRALKSQPKEGIGAPLFPLTTIWGESLLAATPGDGTVPWPEHPRPQLARTSWQTLNGWWDYAFVSLGSAQEARSSWRNAAMPISWNGKILVPFSPEAQLSHVGRQLKPNELLWYRLCFDASRPLPGRRRILHFEGVDWACAVYLNGKRLAEHRGCYLPFDIDVTSAVKDGENALAVCVFDPSDTGTQLRGKQRLVRANMWYTAQSGIWQSVWIEDVPKDHVRQLQVSANPDDGTISVTAQVSHPGRRLVLSLKSGRSAMGPVAKKHEATVRLRVQAPQLWEPDNPRLYDLTLGYGEDEVTSYCAFRSVAVEPDAQGTPRVMLNHRPIFLRGLLDQGYWPDGLMTPPSLDALRSDVQTAHDLGFNLLRKHVKVEGELWYWLCDRMGMLVIQDMPTGGGSYDKWRSINTPTLFRRSWSRFRDDTPSHWRKLAADDNSYRREWQHTRDLTVRRLAAHPSVIAWTLFNESWGQFDSFGQAQRTRELDPTRPVIAASGWYDQGAGNFVAIHNYFRSLQVYPHKDDRAFILNEFGGLSLRVEGHCSLETSYGYDVFEDTAAFRQAVSRQLAQADALEPRGLAGFVFTQLTDIEEETNGLLSYDRRVSKLPVPKADPRACPAYPSEPTAHSPRHSDRTPKK
>NZ_CP012069|44499:169886|128774_130145_-|WP_050342572.1|DBSCAN-SWA
MNLGMETECVEYKRSTSEMREGMESIASILNKHGHGTLYFGVRPSDGEVVGQDVSEKTLRDISQKVGELIEPRIYPQIERLETLEGKAYVRVEFSGFETPYACDGRYRIRRADEDIVMSHAKLAEMMRESENRSNPWDSRNSDTPVSAVDEKALRRYVERGVEAKRIPFSYTEPTDVLSRLGLLCEDGMLTNAAAVCFVPSKDIMLKMGVFADSKRVHILDNQQVTGTLFSMVDAAELYILNNIRRAFVIDGSSLHRREVPEIPMDAVREALFNAFAHRQYEDDSAIQIDVFWDHVYIYSPGLFPVGFNPEDYLTGEESTSKPRNRLIATTLYRSGDIEIYGTGLQRIKAACDEANVPFSVTQSRHGVHVSFMRSEGIAAGNTPATVDARRQGDARTAILRYARGHNGITTAATSELVGEKDYTARRLLNSMVEEGLLEKTGGRKGRVYKAIRHSH
>NZ_CP012069|44499:169886|122314_122611_-|WP_050342554.1|DBSCAN-SWA
MPSDALFGVSGFNGTLSNPIPLHAMLGDSRAALAARDCLAPRQVKATYGTGSSVMLMAGDAPIRSTHGLVSSIAWSLEGGLPYVLEGNLRYTGPSSPG
>NZ_CP012069|44499:169886|108032_108242_+|WP_050342534.1|DBSCAN-SWA
MKFLRETLEDDAPSQELELNDEGVACALRLVRPLVDVRSHDYLPPRVGARPLARLAGRMAPAGKRQCKG
>NZ_CP012069|44499:169886|152473_155629_+|WP_050342622.1|DBSCAN-SWA
MADIFTSEAEFEAAVVSCLQDHGWKGGVLRQPTEQGLLDNWAHILYENNKGDRRLNGCPLTQGEMQQILEQVAKLRTPMRLNGFINGGTISITRDNPDDVAHFNREVSLYIYDRRDIASGRSVYQIAEQPIFKASSARLNDRRGDLTLLINGMPLIHIELKRSGVPVSQACNQIEKYAHEGVFTGLFSLVQIFVAMEPAETVYFANPGKDGDFSLYRFHWADFNNEPINEWQRVIATLLFIPMAHQLIGFYSVADERDATLKVMRSYQYYAAAAISDRVRRASWDKRGARGGYVWHTTGSGKTMTSFKSAQLIADSKDANKVVFLVDRIELGTQSLDEYRNFANDSTTVQATQDTDVLRSRLKSDNPADTLIVTSIQKMSNIHEHDGGMTAADLERVREKHIVFIVDECHRSTFGDMMQTVRRTFPTAMLFGFTGTPIQDENQKKMNTTMDVFGDELHRYSIADGIRDHNVLAFDPYMVCTYKDKDVRREVALEKARADSQATALADPKKKKVYLHFMNEVPMAGARRPSGGCDKGVEDYVPESQYSGPDGEGSPEHFRMVLADIVDNWATLSQGGKFHAILATASIPQAITYYRMFRDEAPQLKVTALFDPNIGNDNPDNPAGTIFKEEGLVEILDGYAKLYPGKDYTIPTHARFKKDVAARLAHKRPYVGIERHPDKRLDLLIVVNQMLTGFDSKWVSTLYLDKVLEYEGLIQAFSRTNRLFGPDKPFGIIKYYRYPHIMKRNVDDAVRLYSGDRPFGLFVDKLEANLEHINQCYADISALFSAYGVEGFARLPDPNAARAQFAKLFKQLSDYIEAAKVQGFSWDKDSYAFECEDGAVTVKTALDQQVYLVLALRYKELFQEDDGGDGPTDVPFEIDGYLTEIDTGRIDADYMNENFAKWLKQIDEGEEAQATLSLLHGSFATLTQEQQRFAELVIHAAQRGELEVIPGKTFLDYINDFQQQGRNSQVEALVAATGVNADKLRDLMARHPSADTINEYGRFKALVATCDKKRAAAHFAEKGKGPVRPSQVNMKLDKLLREFVIQGGIDV
>NZ_CP012069|44499:169886|85405_87364_-|WP_050342504.1|DBSCAN-SWA
MALDHAQAAKEILEAVGGPGNIVSAAHCATRLRLVIADDSKVDQEKVDDAVGAKGNFKASGQLQVIYGTGTVNKVYEELCKQGNISAASKADVKEAAAQQQNGFMKAIKVLSDVFVPIIPAIVASGMLMGIMGAIQFMGTPAPDGAGLFDLDTTSVWWRIAALVNACALANLQILLGFSAATVFGGNPYLGASLGALLISSDFISAYSASKALSDGTMITLQVIPGLYSIDWIGYQGHVIPILVGVWILCFFEKRLHKAVPEMFDLFVTPLVSVSVAAYITILFIGPIFVWLENAILGLLYFLLKVPLGIGYIIIGLIYSPSVVTGLHQMYTAIDVSMLAQPGNVTRWLPIASAANIAQGGACLAVALKTKTVKTKSLAVPSGISCLLGITEPAIFGVNLPKVKPFVCGMAGAACGAFVCYLTQLAATGTGVTGIFGLLLCVKQPVQYIIMFVVAFGVAFGLTSAIYKDEDKPKKKVAAPTPKPETSTSTTAAPSAKAVAATGPEAIVSPMAGEAISMTAVSDPVFASEAMGKGAAVEPTEGKVFAPADGSITMVAETGHAIGLLSEGGVEILIHIGIDTVNLKGGPFTAKCQAGESVKKGDLLMDVDLGAIKEANLPATTMVIITNTDDFSSVEGHTGTVKVGDTLIDIKK
>NZ_CP012069|44499:169886|133878_134952_-|WP_050340811.1|transposase|DBSCAN-SWA
MAQLTFSDVEMGMGRKRETRRSRFLDRLSKSCPWDAWLALVREARGADAGARGAGPAMGRPRVDDLVLLRMYMVQVCFGLSDRECEDQVWDSATMRSFVGVAPFEVPDATTLCKFRHLLERCGVGEAMVSSAFGSAADGGLAVSRGTIVDATFIESPSSTRNADGARDPDAHQAKKGQNWHFGYKLGVGVDAETGVPHSVRMDAANVHDLDQVPDLVREGDERVWADAGYVGVGRRPEVAGDPSLSGVEWIVAKRRSQVGEDDLVAEAAKSAARSVVEHVFHWVKDIFGLRKTRYKGLAKVSNQAFAAVAAAGCMIARRGRRLCGPPLALSAERIALQRERLEERRRRAEGGAPAAA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
44351:44410	attL	NA	NA	NA	NA
WP_050340583.1|44499_46116_+|transposase	transposase	NA	NA	NA	NA
44351:44410	attL	NA	NA	NA	NA
WP_050342434.1|46581_47154_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_050342436.1|47346_47691_+	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_157051312.1|47898_48048_+	hypothetical protein	NA	NA	NA	NA
WP_050342438.1|48626_49169_+	hypothetical protein	NA	NA	NA	NA
WP_083443687.1|49718_50138_-	class II fructose-bisphosphate aldolase	NA	NA	NA	NA
WP_050342442.1|50207_50654_+	hypothetical protein	NA	NA	NA	NA
WP_050342446.1|50640_51183_-	DUF1697 domain-containing protein	NA	NA	NA	NA
WP_050344639.1|51705_52485_+|protease	YhfC family intramembrane metalloprotease	NA	NA	NA	NA
WP_050342451.1|52919_54368_-	putative DNA binding domain-containing protein	Q6GYZ7	Mycoplasma_phage	7.0e-29	26.4
WP_050342453.1|54364_54865_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_050342455.1|55503_55839_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_050342457.1|55898_56459_+	DUF2812 domain-containing protein	NA	NA	NA	NA
WP_050342460.1|56792_57089_+	hypothetical protein	NA	NA	NA	NA
WP_050342464.1|58639_59077_+	hypothetical protein	NA	NA	NA	NA
WP_050342466.1|59231_59708_-	flavodoxin	NA	NA	NA	NA
WP_050342469.1|60604_61597_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_050342471.1|61715_62315_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_050342472.1|62492_63737_+	alpha-amylase	NA	NA	NA	NA
WP_050342473.1|63768_64305_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	4.0e-30	43.8
WP_050342475.1|64353_65712_-	triacylglycerol lipase	NA	NA	NA	NA
WP_050342476.1|65800_66976_-|protease	ATP-dependent Clp protease ATP-binding subunit	NA	NA	NA	NA
WP_050342478.1|67731_68406_+	TIGR00266 family protein	NA	NA	NA	NA
WP_050342480.1|69097_69391_-	hypothetical protein	NA	NA	NA	NA
WP_062393035.1|69476_69638_-	rubredoxin	NA	NA	NA	NA
WP_050342482.1|69676_70864_-	flavodoxin domain-containing protein	NA	NA	NA	NA
WP_050342484.1|71129_71804_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_157051313.1|71834_72209_-	hypothetical protein	NA	NA	NA	NA
WP_050342488.1|72245_72578_+	PadR family transcriptional regulator	NA	NA	NA	NA
WP_050342490.1|72628_73189_+	DUF2812 domain-containing protein	NA	NA	NA	NA
WP_050344641.1|73380_73677_+	DUF2089 family protein	NA	NA	NA	NA
WP_050342492.1|73679_73976_+	hypothetical protein	NA	NA	NA	NA
WP_050342493.1|74237_75197_+	3-hydroxyacyl-CoA dehydrogenase	NA	NA	NA	NA
WP_050344645.1|75684_75948_+	hypothetical protein	NA	NA	NA	NA
WP_050342495.1|76068_76842_+	hypothetical protein	NA	NA	NA	NA
WP_083443689.1|77290_78244_+	ATP-binding protein	NA	NA	NA	NA
WP_050342497.1|79015_79831_+	tyrosine-protein phosphatase	NA	NA	NA	NA
WP_050344648.1|80247_80793_+	hypothetical protein	NA	NA	NA	NA
WP_050342499.1|80969_82430_-	glycoside hydrolase family 32 protein	NA	NA	NA	NA
WP_050342500.1|82743_84261_-	glycoside hydrolase family 32 protein	NA	NA	NA	NA
WP_050342502.1|84329_85280_-	sugar kinase	NA	NA	NA	NA
WP_050342504.1|85405_87364_-	PTS sugar transporter subunit IIBCA	NA	NA	NA	NA
WP_050342508.1|87697_88681_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_083443691.1|88757_90677_-	hypothetical protein	L0N6M2	Herpes_simplex_virus	4.6e-20	26.7
WP_050342510.1|91029_91995_-	Abi family protein	A3QSC6	Clostridium_virus	6.8e-28	27.2
WP_157051316.1|92127_92787_-|integrase	tyrosine-type recombinase/integrase	A0A097BYJ7	Leuconostoc_phage	1.1e-13	32.1
WP_172674408.1|93048_94404_+|tail	phage tail family protein	NA	NA	NA	NA
WP_157051318.1|94412_94811_+	hypothetical protein	NA	NA	NA	NA
WP_050342518.1|95195_95414_-	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_083443693.1|95501_96395_+	N-acetylmuramoyl-L-alanine amidase	A0A2K9V338	Faecalibacterium_phage	2.1e-44	48.1
WP_050342522.1|96823_97810_-	ORF6N domain-containing protein	NA	NA	NA	NA
WP_050342524.1|98303_100094_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	5.3e-26	23.4
WP_083443694.1|100069_101857_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	5.2e-42	30.3
WP_172674409.1|101979_102654_+	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_050342528.1|102650_104126_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.0e-14	30.9
WP_050342530.1|104186_104825_+	MptD family putative ECF transporter S component	NA	NA	NA	NA
WP_050342532.1|104980_105625_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_050340583.1|105989_107606_+|transposase	transposase	NA	NA	NA	NA
WP_172674410.1|107887_108034_-	hypothetical protein	NA	NA	NA	NA
105841:107630	attR	NA	NA	NA	NA
WP_050342534.1|108032_108242_+	hypothetical protein	NA	NA	NA	NA
105841:107630	attR	NA	NA	NA	NA
WP_172674411.1|108718_109228_-	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_050342536.1|109224_109647_-	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_172674412.1|109634_110867_-|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_172674413.1|110863_111052_-	hypothetical protein	NA	NA	NA	NA
WP_050340583.1|112287_113904_+|transposase	transposase	NA	NA	NA	NA
WP_083443699.1|114096_115260_+	hypothetical protein	NA	NA	NA	NA
WP_083443700.1|115605_116541_-	ORF6N domain-containing protein	NA	NA	NA	NA
WP_172674414.1|116645_117635_-|integrase	site-specific integrase	S5MNZ2	Brevibacillus_phage	9.7e-22	30.7
WP_157051322.1|117651_117963_-	DUF3784 domain-containing protein	NA	NA	NA	NA
WP_050340583.1|118471_120088_-|transposase	transposase	NA	NA	NA	NA
WP_050342548.1|120401_121691_-	prolyl oligopeptidase family serine peptidase	NA	NA	NA	NA
WP_050342550.1|121760_122306_-	hypothetical protein	NA	NA	NA	NA
WP_050342554.1|122314_122611_-	hypothetical protein	NA	NA	NA	NA
WP_050342556.1|122911_123097_+	hypothetical protein	NA	NA	NA	NA
WP_050342558.1|123130_123607_+	ATP-binding protein	NA	NA	NA	NA
WP_050342560.1|123670_123928_+	DUF4143 domain-containing protein	NA	NA	NA	NA
WP_050342562.1|123924_124341_-	YjdF family protein	NA	NA	NA	NA
WP_050344655.1|125200_125761_+	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	NA	NA	NA	NA
WP_050342564.1|125781_126177_+	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_083443704.1|126098_126665_+	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_157051323.1|127317_127938_-	hypothetical protein	NA	NA	NA	NA
WP_050342572.1|128774_130145_-	putative DNA binding domain-containing protein	Q6GYZ7	Mycoplasma_phage	9.9e-33	26.1
WP_050342575.1|131000_131255_+	hypothetical protein	NA	NA	NA	NA
WP_050342577.1|131290_131476_+	hypothetical protein	NA	NA	NA	NA
WP_157051324.1|131468_132047_+	hypothetical protein	NA	NA	NA	NA
WP_050342581.1|132074_132803_+	MFS transporter	NA	NA	NA	NA
WP_050342585.1|132806_133724_+	ribokinase	NA	NA	NA	NA
WP_050340811.1|133878_134952_-|transposase	IS5 family transposase	E5E3P6	Burkholderia_phage	5.2e-53	39.9
WP_050342587.1|135580_136414_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_050342589.1|136895_137897_+|transposase	IS5 family transposase	E5E3P6	Burkholderia_phage	2.3e-71	45.4
WP_157051325.1|138744_139617_+	hypothetical protein	NA	NA	NA	NA
WP_050342598.1|140152_140446_+	hypothetical protein	NA	NA	NA	NA
WP_050342601.1|140583_140901_+	hypothetical protein	NA	NA	NA	NA
WP_050342602.1|141151_141646_-	helix-turn-helix transcriptional regulator	A8ASM2	Listeria_phage	2.4e-05	36.9
WP_050342604.1|142057_142300_+	hypothetical protein	NA	NA	NA	NA
WP_050342606.1|143423_143651_+	hypothetical protein	NA	NA	NA	NA
WP_050342608.1|144032_144239_+	hypothetical protein	NA	NA	NA	NA
WP_050342611.1|144238_145147_+	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_050342612.1|145154_147728_+	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	9.1e-96	41.0
WP_050342613.1|147724_148933_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_050342615.1|148960_149146_+	antitoxin VbhA family protein	NA	NA	NA	NA
WP_083443706.1|149138_149795_+	Fic family protein	NA	NA	NA	NA
WP_083444065.1|150354_150981_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_050342621.1|150992_152474_+	putative DNA binding domain-containing protein	NA	NA	NA	NA
WP_050342622.1|152473_155629_+	type I restriction endonuclease subunit R	NA	NA	NA	NA
WP_050342624.1|156182_157115_-|integrase	site-specific integrase	A8ATD6	Listeria_phage	4.3e-80	50.5
WP_157051327.1|157913_159371_-	AAA family ATPase	NA	NA	NA	NA
WP_050342628.1|159722_160394_-	response regulator transcription factor	NA	NA	NA	NA
WP_050342631.1|160593_161676_-	hypothetical protein	NA	NA	NA	NA
WP_083443707.1|161668_162400_-	ABC transporter ATP-binding protein	W5SAS9	Pithovirus	3.4e-16	29.9
WP_050342634.1|163800_164277_+	hypothetical protein	NA	NA	NA	NA
WP_050342635.1|164273_165497_+	hypothetical protein	NA	NA	NA	NA
WP_050342636.1|165496_166162_+	ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	1.6e-12	31.4
WP_050342637.1|166313_166928_+	hypothetical protein	NA	NA	NA	NA
WP_050342640.1|168419_169886_-|transposase	transposase	NA	NA	NA	NA
177277:177299	attR	NA	NA	NA	NA

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NZ_CP012069|946274:1016854|DBSCAN-SWA
GCTAGCAGTTCTTGACGGAAAACGCGACCCCGCGCTCCAGGCACATCTCGCAGGCATCTGCGGCGCGCTCACAGCTGAGCTCGAACTCCTCGAGGAAGCTTCCCTTGAGTTGGCGCAGGGCATAGTCAGCGACGCTCATTCTCCCGGGTGGCCGTCCAATGCCCACGCGCACGCGGGCGAAGTCGCGGGTGCCCAGCTTGTCTGCGATCGAGCGAAGGCCATTGTGGGCGTTGAGGCCTCCGCCGCACTTGACGCGCACCTCTCCCTGCGAGAGGTCCACCTCGTCGTGGACAACCAGGATCTCTGGTGCCAAGACCCCAAGCTCGCGCATGAGCTTAGAGAGGGGTCCGCCGCTCGTGTTCATGTAGCTCTGCGGCTTTGCGAGTACGACCGGACATGGATCACCGTCCGTCCCCTTGAGCTGGATGCGACAGGTCATGCACCCCGCCGCGCTCTTCCAGAACGAGGCGTGAGCGCGTCGCGCGAGGATGTCAATGGTGACAAAGCCGGCGTTGTGACGAGTGCGCTCGTACTCGGCACCGGGGTTTCCGAGGCCGCAGATGAGTCGTATGTCATTGGGCTGCGCGCTGGCTGGCATGCTGGTCTCCCGTCGACGTGCCGATGCTGCACCTCCACTATAGCTGGAAGGCAGATGATTCTACAGCAGCTTGATTGGATGGTCGGGAGTGTGGGGTAGCTGTGGTGCACAGGTGCAAGGTGGCGCCTCGCCGTTGGCGTCTCGTGATACTCCGCGTGCGCTTGCGGCTACCGTCCGTTGGAAACGCGTTGGATGTAGCGGCCCATCCCCGGCACGGTGAAGTCGAGCTGGCCTGTGCGAGGTGCATATATCAGGCCCGCGTCAACGAGCCGCTTGCGCACAGACGTGAGGCTGCTCGGCTTGCGGCCCAGGCGCCGCGCGAGGTCATCCATCAACGAGGCACCCTCGTCCAGCGACATGGCCTCCATGAATCTGCGCTGGGCGTCGGTCGCACGATCCCAGCGGGAGCGGTACAGCCCGCTGTCCACCTCGTCCTGCGCCAGCCTCGTGGCAATCATCGCGTCCTCATCCGAGATCAGCGTGGACGAGGTCCTCTGTTCCCACGCAAAGTAGCCACAGCTCTGGACAAAGTAAGGATAGCCAGCCGAAACTGCAGTTACGCGCTGTATGGCGCCCTCATCCCAGCTCACTCCAAGGCGTTCGCAGGGCTCCTGCAGCGCGAGGCGCACGTCCTCGTTCGAGAGCAGATCGAGCTGATGGTAGCGGTACATGCGCTCCGCATAGCTCGTTGCCTTGGCAAGGATGCTGGGAAGTGTGGGAAGGCCTGTCCCACAGAAGAAGAGCGGCGTCTGCTCATTGCCCTGCCCGAGGGTGTGTAGCGCGACGTTCAGGGCGTCAAGCTCCTCTTGACCGGCCTCCTGCAGCTCATCAATGCCGAGAAACACAGCTGTACTCGAAGCGTGAGCTGCGTCACCCAGCGCGCGAAGCATGTCCTGAAGGTCTAGAGAGAGGTTGCCCGTGTCAGCATAGCCCCGTGCAGGTTCCACGTCGATGCCAATGGAGTATGAGCCGCTTGGGTCGATGGTGAGCTGAAACGATCTCAGCACCCTCACAGCGCGCGCGAGGGTGTCAGTAATGCGCTTTGATCTTGTTCGTATCTGCCTGAGCTCCAGATAGGTTGCCTGTGCAATGCGTTGCGAGAGTGACTCGCGCTCCGTCGCCTCCGTGAGGATGACGATCCAGCCTGAGTTTCGTGCATGCTCGGCAAGTTCGTTGAGCAAGACAGTCTTTCCGATACCTCGCAGCCCCCAGATGACGCACGGTCGTCCCTCCTCACGCTTCGAGACGACACGACCCATGTCAAGATGCATGGAGGCAATAAGACGGTCGCGACCAGTGAGGAGAGGAGGGCGTCGTCCGGCGCCGGGGTTGAAGGGATTGTCGGGCTCACCCATGCTGCCTCCTTTCCATAACGGCGGCTTCATTCGTTTATATCCGTTCGTATTTGATCATATCTTGAATTCTAAATATGATCAAATACGAACGGATAGAGTGGGTTTGCCGGAGATCGGGGGCGACCCTGTCGATTCCCCGCTGACATGGAGCGCGACTGACACGAGGTGTTGCGGGAAAGACGGCGCTGCCCTTGTCGCGATGTGAGTGATTCACTCACATCGAGCTTCTCTTCAATAAGCGTCTGAACTGCGATGATGTAAATTCACTCTCCTGATGCGCATGGAGTTTGGTGCGAAAAATCACTCACTTCGCGATGGCGATGTGAGTGATTCACACACTTCGCGAGCTATCGTGGGGGATCCGCGCGTCGTGTAAACGGTCACGTGGCGTGCCCTTGCGGCGGTTGACGTGGGGACGCTGCGCTAGACGTTCTTTCTCAATCAAACACGTGTACTGGGCGATGTGACATCGTCTTTTGTCTCCGATTTCGAGATTGGCGGCAACACATTTGAGGTAGGGGGCCGCTCCAAGGGGCAGGACCAGCTTGCTGGGGTGCAACACGGCTATGTGGTGAGAGACGATATCGAGCATGGGTATGGCAATGTGATTCCCCTGTGGGCATTCGGCCTGGGGTATTAGGTCGAGGTCGTCTTGCCTACACGCAGGCTGCACATAGTACGTGGTGCCATGTGGCAGGACCGGCCATAGTTTTTGACCGCGCGTGCACGTCGCTGTCTACCGCTTGGTCTCGGACAGCCCTCATTACTTACTGCCTACTCATCTTTCCCTCAAATGAGTACGTCCTGACATGACGCTGTATGTTCTCTCCACGCTCGAGATAACGCAATAGTATCTGAGCGCAGGCGCGGCTGTCGCTTTCGGCTCGATGATGGTCGAGGTCAATGCCGTAGTACTCACACAGCACGTCTAGCCTGTGGCTCATTCCCGGAAGCAGCCTCCTGCCCATCTGCACGGTGCACAGGTAGCTGGCCCGGGCCTTCCAAGCGATGCCGTAGGCGTCAAGGCACTTCCTGAGAACCCCCAGGTCGAACACGGCGTTGTGCGCTACAAGCAAGCCGCTCGACATCACTGGCTCGATCTGTTCCCATGCTTTTGGGAAGGTCGGTGCGTCTTGTACCGTCTTTGCGCTTATCCCCGTAAGTCGGGTGTTAAAGAGATCGAAGTGGCTCTCCGGGTTCACGAGGGTATGGTACTCGTCCTCGACCTCGCCGTCTTGCACCACCGTGATCCCGATGGAACTCATGCGGTCATTCAGGTGGTTTGGGGTCTCCACGTCAAATGCTATGTATCTCTCCATATGTGGTCCACCTCTTCTGCTGGTCTTCGTAGCAAGGAGGCTCTCGTCCTCCGTCACGTCAAAGGCGTGTCTCGACCTCGTCACCGCCGTTCCCGCGCCCTTCTCAACCGTACTTGTATCTCCGTCAGCATACAAAGCAAACTGTGTCGCTCGCAAGGTGTGTGAACCACTTGGCTTCATCTCGTCCCCGCGCTTCAAGTCCCACGCCACATACGTGCAATCTGCGTACTTGAAGTACCCGATAAAATGAGACAGTGGGGGATTCGCACGGTTAGAGGCAGAATGCGAAGTAGAGCGGCAGCAGGGTTCTCTGACCCGAACTCGCCACCTGCCTTGGGTGCAGCACGTAGGATCTGCCGAGCCGATCGCCAAAGGTCCGCTCGAACTTGTCGAGCAATGATGTGCCGTAACGCTTCGTTGACTTGACCTCGACAGGGCTCACGCGGGCCCTCAGGTTCGCGTCGTCATGCGCACGTACGATGAGAAAGTCTATCTCCATCGTCCTTTGGGAGTCGCCTCTCGCATAGCGGGAGTAGAAGAAGAGCCTCCGACCGTTTGCCCTGAGCTGTTGTGCCACAGCGTTCTCAACGAGCATTCCCTCGTTGAGCGAGAGCCTGTCAAAGAGGATATCCCTATATACCTCACTCGGCGTCGATCGACGATCGGCGAAGACCTGGGAGACGAGCAGCCCCGTATCCGCCATGTAGCACTTGAATGATGCGTTGTCCTCGCTGAGGCCCAAGCCGACCGTCGGATCGGTTGCGTTGCGACATATATTGGTGAGTCGCGCGTCTTCAAGCCAGAAGAATGCGGAGTCATAGCTCCTCGACCGTGCCTCGCGGTCGATTGACGCCAGCGTGAACTTCTTCTCATGCTTCGAGAGCTGTCCGGGTATCTGTGAGAAGATGCTGCGTAGCTTGCCAGCGTCGCCGTTGGCGAGCTTTCCCATGTCATTGAGGTAGAGATCGATGATGCCGCGCTTGATATAGTCCACCTCATTGAAGTCTCGCGACTGCACGTATTCGTTGACTGCCTGTGGCATGCCGCCTACGAGCAGGTATTCGCGCCAGAGCCTCATGGCTCGCTTGTGAAGGGCATCTGGCAGCTGCCTTGAGGTCTCGAAGGAGTTCCTGATGAGGTCCGACAGCAGCTTCTCGCCCATTGCCCAGCAGAATTCCTCGAAGTCCAGGGGATCCATCTCAAGCTTGCGTTCCTCGGAGGGAATGACGATATCCTTTATATGTCTCTTGATGGAGATGAGCGACCCAGTCTCCATGAAGTCGTACCGTCCATCAGCGACAAGGTGTTTGATCATCTCGCGTGCCTTCGGATAGAGCTGTACCTCGTCAAACACGATGAGCGATTCACGCGTGTGCAGTGGCGTCCTGTAGTAGGCGGACAGAAGCATGAAGAACGTATCAAGGTCATCGCGCTGATCCTCGAAGATGGATCTCACGTCGCGCGGCAGACGCGAGAAGTCGATGATGATGCTCGAGCGATACTCGTTTTTTGCGAATTGCTCGACCGCCGTGCTCTTGCCGACGCGCCGTGCTCCCTCGATAAGAAGGGCCTCCCTGCCCCTGGCGCGGGACTTCCACCTGCGCATGTGATCAAGGACTTTTCTCTCAAGCATCAATCTCCTGTTCATACGTTCGTATAACACGATGCCGCAACATGGGATAAGCTCATTTTACACGATACCGTCGTGTGAGACTGCAGAGATACGCACGATGCCGCTATGTGGAACGAAACGCGGCGACTTTGCGCCTAGGATCCTGCTCCCTACTCTTGCGTGTCGTCTGGAGTCCCCGCGCGCCACCGTTTGACATCGGACAGGCGCTCGGAAAGCCACGCCTCGCGACCCTCGCACGTGGGGTGATAGTACTCAGATCCTGCGAGTGAGTCGGGCAGGTACTGCATGTTGGCAGCCACCTTGTGCTTCTCGTAGTGTGCCAGGCGGTAGTCCTTACCGTAGCCCAGATCCTTCATCAGGCGCGTCGGGGCGTTACGGATAACGAGCGGCACGGGCTCCGCCATGCTGTGCAGGGCGTCCTTCTTGGCACGCTCGTAGGCGATGTAGCTGCTGTTTGACTTGGGTGCGAGAGACAGGTATATGACCGCCTCGGTGAGGTGCACCGAGCACTCGGGCATCCCGATGAAATGGCAGGCGTGGAAGGCGTTCACGGCTACGTTGAGGGCGTTGGTGTCGGCGAGGCCAACATCCTCCGACGCAAAGCGCGTTATGCGGCGGGCAACGTAGAGCGGGTCCTCACCGGATTCGAGCATGCGCGCGAGCCAGTATACGGCGGCGTCGGGGTCGGAGTTGCGCATCGACTTGTGTAGTGCACTGATGATGTTGTAGTGCTCCTCACCCGTCTTGTCGTAGAGTAGGCTGCGCTGGCCCGTGCACTGCCTTACTGTCTCGGGTGTTACCGTGACCACGTCGCCTTCCGTATCACCGTTGAGAACCACCATCTCGAGCGTCGAGAGCGCCATGCGCGCGTCACCGTTTGCGAACGTGGTGATGGCGTCAAGCAGGTCGTCAGCAATTCTCACTTCCTGTCCGCCGAAGCCACGCTCATCGGTCAGCGCACGGCGCAGCAAGCCCTCGACCTCCTCCTTGGTCAGCCCCTTTAGCACGAATACCTTACAGCGTGAGAGGAGCGCCCCGTTCACCTCGAAGGACGGGTTCTCGGTCGTGGCTCCGATGAGCGTGATCGCGCCCTCTTCCACGAAGGGCAGAAACGCGTCCTGCTGCGCCTTGTTGAATCGGTGAATCTCGTCGACGAACACGATGGTGCGCCTGCCTGTATGCGTCTGCGCACCCGCACGCCTCATGATCTCGCGGATCTCCTTGATGCCGCTCGTCACGGCAGAGAAGGTGATGAACTCGGCACGTGTCTGGCGCGCGATGACCCGCGCGATTGTGGTCTTGCCCACGCCGGGAGGCCCCCAGAAGATCATGGACGGCAGCTGGTCGGCCTCGATCATGCGGCGTAGCACGTTGCCCGGTCCTATGAGGTGGGTCTGTCCCGACACCTCGTCGAGGGTCTTTGGCCGCATGCGTGCTGCGAGCGGCGCCGAGCTGTCCGCCACCTCTTCGTCAGTGGTGTCGAACAGCGAGCCCTGTCCCTCGAACGATGGCTTCATCGCGTGCCCCTTTCCTGTTGCATGCGTCACATGAGCAGGCGCAGATCTTCTAAGAAGAATAAGCCCTAGTTCTTTCTGATTGTAGAACTACCGCCTGATCAAACCAAAGAAAATCGAGAAAATCGCAGGTCGAGGCCCCAAGGGGCCTCTCTTGTGCTATATTATATGTAGTGCTACTTACTACTTCCTGTGTGGCACGGGAGGCGACCGGGATGCCGTTCATAAAGGTGCAGAAGCTGGTCAGGGACGAGTCCGGCGCAATCAGGAGCGGGTCCGCCGCCGTGGTCGACACGTCGTACGTGCGCGGCGCCAAGTACCACTCGGCGCAGGCGGTGCGCGAGAGGCTGGGCAAGGTCGTCTGGCTCGCGGACGACAGGCGCTCGGGCGTGTTCGCGTCACCGACGCGCGGCCTGGTGGAGTACGACGCGGACGCCGACGGATTCGCGCCGGTGGCCAAGGGCGACGAGCGGCTGGCGAACACGGGCGCGTTCCCCGAGCCGCCGCGGCACCTGGAGCTCGGCCCCGAGCACCTGCTGCTGTCGTTCCTGGGCGCCGATGGGGTCGCGGGGTGCCTCAGGGAGGCGCTCCCCGACGACCGGTCCTACCAGCGCGCCCTCGCCCACGTCACGCACGGCGTGGTGCGGGACGGGAGCCGCGAGACCTGCGACAACATGGTGGCCAGGTCCTTCGCGGCTCTGGCGCTGCCGGGCGTGCCGCCCGCGTCGCTGAGATCGGACACGGCGTTCTTCTCGGCGATGGGCGCCGACGGGGCGAAGGTCGCGTTCTTCAGGGCGTTCGCCAGGCTCATGAGGAGGACGAAGCCCGGCTTCGGCCGCGCATGCTACGTGGACTCCACCCCGCTCCCGAACGACGCGGTCGACAACCCGCTCAACGCCCTCTGCAGCCACGGGCTGAGGGGCGCGGCGGTCCAGATGCGCCTCGCGCTCGTGCTCGACGAGACGACGGGGCTGCCCGTCTGGTACGAGGTCGTGCCCGGCAACGTACTTGACCTCTCGACCATAAAGACCGTGATGGGCGACGTCCTCGCCACGCTCGGCATCGAGGTCGTAACCGCGGTCCTCGACGCGGGCTACGCGTCGCGCGAGCTGCTCGAGGCCTTCTCCGAGGGCGAGAGGGACGTGCTGGTCAGGATGCCGGCGAGGAGGGGGTACCCGTACCGCGAGCTCTGGCGGGGCGTCCGCTCTCTGATCGGCAAGGGCAAGTACGCGATCACGCGCTCCGGCCACCTCTACTTCGCCAGGAGGCGCGACGTCGAGGTGCAGGGCGTGAGGCTGCACTGCTACGTCTACGTGGACCAGACCAACGCCACGCCGCGCTTCGCCAGGTGGCTGGACAAGAACCAGGAGAGGTTCGACGGGATGTCGCTCGCCGAGAAGGACTGGGAGACCGTGCGGCAGGGCTACTTCGTGCTGATGTCCACCAAGGTCGCGACGCCCCGCGAGATCCTGGACGAGTACTTCTGCCGCACCGAGATCGAGGGCGTCTTCAAGACCAGCAAGGACTACCTGGGCCTGCTGCCGCTGCGCAAGTGGAGCGACCTCACCGTGCGCGGCAAGATCCTCGCCGACATCATCGGCACCATCGTGGTGCTCAGGATGCGCAAGGCGCTCGCCGGGGCCGACGTCTCCCTCACCGAGGTATGGGGCAAGGCCAGGTCGCTGTCCTGCTACACCAACGCCGACGGCAGGGTCGTGGTCGAGACGCCGTCGAGGCAGGTCCGCGAGTACTACAAGGCGCTCGGGGTGAAGGTGCCCTCGTCAATCGACGTCAGGGAATTCGACCGTGACGTCCTCGGCCTGGAGCTGTAGTTCTACAATTAGCGTCATCTAGGGATAAGTGTACGGCATTCGAAGCTCCATCATGAGCATCCGAGTACATGCGCGTTCTCATCCTTAGCCGGTGAGTTGATCTTTACTTCCCCGGAGATTGCCTGCATGCTCCAAGGGAAAACCGACCATCTCAGCCGTCGGTCATGACGCGCCCCCGCGCTACACCAAACCGGCCTTCTGGAAATGCTTCTTAAGCAGCTTGCGCGCAATCAGGGATCCGAGAAACGCGCACAACGCCACAACCAACAGCATGGCTACTGCCATCGCGGGGGAGACTATCGTGCTCAGCAGTTGCATGTAGTCCTCTCCGAACTGCGTCGAGTACTGGGTGAGCGTCTGCTGGGAGAAGAACAGGAAGGGCACGTACATGCCGCCGAAGGCCGCGAGTACCATGTACACGACGTAGCTCGCCGTGAGCGCTCTCTCGTTCGTGCAGCTGGTCTTCGACGCCAAGGTGGCAGCAATGACGCCCGCTATCAGGCAACACACGATCATCGGCACATAAAGGCCATGCACGCCCGTGAGCGCGCAGAACACGAACAGCGCCCAGGATTTCTTGGTTCTTGCCGCGACCAAGAAGTACGTAATACCAGCTAGCAACGCCCAGAGGGGACTCACTGCCAGCATGGTGTAGGGCGAGAAGGACAGTATCGCGCACACCATGTAGATAGCCAAGGCGCATACGGCCAAAAGCGCGGTCACTATCAAATCTTTGACCTGAAATTCAGTTTTTCCTTCGTTTCCCATTGTCTATCCTCTCTTTGAGATTAACTGTTAGCGCATCGACAATGAAACTCCCACGACAAGCGCGAAGAGCGCCGTCATAAGCGCAACGAGGAGGCCGTCCTTCGGGCTGAATTCGGCTATCTGGTACTGCGTCTTCTCACACGGATAGCTGATGCCCCGCGTCTCGGCGGAGGCGGAAAGCTCGGTGGCGGTCATCAGGACCCTCATGAGAATCGGCACGATGAAGGCCTCGTACGTCTGGGCAGGATGGGCGAGAACGCGTCGCAACGACAAGCCGACCCCCCTCGTCTTTAACCCCTGTTTTATATAGATGGCATCCTGCATGATGGAAGGTAGGAAGCGCAGGGCGACGGCAAACGGGATGATCACGACCTGGGGGACATGGCTCGACCGCAGCGACGAGATGAGCTCCGAGATCTCCGTCGTCTGAAAAAGCAGGCTTAGTCCGAGCGCGATCGTGAGCATGCGAAGGAAGAAGAACTGTATGACCGATGCGAGGTGCGCCGGCACCACCTGCGCCAGCAGGAACAGCAGGACGTAGACGGCCACATAGGCAAGCGCGTCTTTCCAGATGCCCGCCAACAGGGCAAACAGGAGCACGATCCCGAACAGGAGCGCCCCGGTGACGCCCCCGCCCAGCGAAAAGGCCAGCGTCGATGTGAGCAGGACCAGTAGCAGCTTAACACGGGGGTCGTAGCGCAATCCAACGGACTGTATCACAGGAGACCACCGCCGAGCATGATCTGTCGGGTCCTTTCCAGCGCCGCCTGCGAGGATAGGGGAAAGTCATCGGCTATGCGTCCCTCGGCGAGCGCAAGGACCCGCGTTGCCGTGAGGTCTACGAGCTCGATGTCGTGCGTGATGACGAAGACGAGCCTTCCCGATTCCCGAAGTTGGTTGATGGCCTGAGCAACCGCGCACATGTTGCCCCAGTCCAAGCCGCTCGTCGGCTCGTCGAGCACGACGATGGGTTTGCTGGAGGCCATGGCGGTGCCGATGGTCAGGCGCTGCTTTTGGCCCCCCGAGAGCGCGTAGGGGTGATGCTGCGCGAAGTCGGTGAGGTTGAGCATGTCGAGGATGCCGGCGATCCTTTCGTCGATGTCGCTCGCCCGCTCGTTGCCGAGGCGCAGCTCCTCCACGGCGCTCTCTTTGTACAGCTGGTGATCCGCTTCCTGCATGACGAAGTACGCGTAGTCGCTGAGCCGCTTTTGCCTCACCTGTGACCCAGCTACAACGAAGCGTCCGTTCCTGCAGGGGATCAACCCCGCCAGCACTTTGCCCAGGGTCGTCTTTCCACTTCCGTTGCGCCCGATTAAGGCGATGACCTCGCCCTTCCACGCGCTGAGCGAAACGTCGTCGAGCAGCAAGGGCTCGCCCCTGTAGGAAAACCTGACGTGACTTGCTCGGAGGAACACATCCCCCCTGCAGGGGGGAGCGGGCGGCGAAGCGTGCCTAAGCGATCCCAGGTCGAATGCGCGCAACTGCTTGTCGTGCAGGGCGTCGGCCGTCATCAGCTCCATATGGCTGCCCGCGCTGTCCTCGATAACCCGTCCCTGTCGCATGACTATGATGTGGTCTACAAGACCTGCCAGCCAGAACAGGCGGTGCTCCGAGACCACGATGGTGTGCCCAGCTTCCTTCAGGGCAGCAAGTACGTCTCTGACCTGGAGAACCGTGGCACTATCTAAGTTCGCCGTCGGTTCATCGAGGACGTATATCCCTGGGTTGAGGGTTGCCGCCGCAATGAACGCAACCTTCTGGCGTTGCCCGCTCGATAGCGAGAAGATGCTTTTCCCTTTCAGGTCCCCCATGCCCAGGGTGGCGAAGGAGTCGTCCACCCTCCTCACGATCTCCTCGTGCGCAACGCCGTAGTTCTCACACGCAAACGCGGCTTCCCCATCACTGCTCGTCGTGAAGAACTGGCTCCTGGGATCCTGAAAAATTGAAGCGACCAGCTTCCCCGCGTCTCCGGGGGTCGTCTCCTTGATAGAACGGCCGCCGACCAGGACCTCGCCGCTCAGCTCGCCCCTGAAGAAATGAGGGATCAGGCAGTTGACGCATCGCGTGAGCGTCGTCTTGCCGCTACCGCTCTCGCCGGTGACCAGTACCAGCTCGCCTGCGTCGATGGTGATGTCGACGTTCTGCAGGCTCCTCTTGTCCTGGCCCTCGTATTGGAACGAGACGTCGTCGAAGCGGATGAGCGGTTCTTGTGCGCCCCCTTGCATGCTGGGCTTACAGCCTCCACTCGATCGACTGCGTGCGGCATCGGATGAACCTGCTGTATATTCCGTCTTGGCTTGCCAGCTGCTCATGAGTCCCCTTTTGGGCGATTTTGCCCTGGTCGATAACGACGATCTGATCCGCATGGCGAACCGTCGAGAGCCTATGGGCTATCGAGATGAGGGTCTTGTCCCTCGTAAGCTCGCGTATGGCAGACAGAAGCTCTTTTTCGTTTTCCGGGTCCACGCTGGAGGTGGCCTCGTCCAAGATGACGATAGGCGCATCTTTCAGAATGGCTCGCGCGATGCTGACCCGTTGGGCCTCTCCGCCCGAAAGCGTCGAGCCGCCAGCCCCGACAACCGTGTCGTACCCGTCCGGCAGGGCTTCGATGAACTCGTGGCAGCGCGCCTTCTTCGCGGCCTCGATGACCTCCGTCCGGCTTGCCTCGGGCCTTCCGAAGCGGATGTTGCTCTCGATCGTGTCATGGAAGAGGTAGACGTTCTGGAAGACCATGCTGACGAGCGAAAGGAGGCTGCCGCAGGTGTACTCGCGCACGTCGTGCCCCCCGACAAAGACGGAGCCCGACTGGACGTCCCAGAACCGCGCTATCAGATTGCACAGCGTCGTCTTTCCCGAGCCCGAGGGACCCACGATGGCGCACGTGGTGTTTTGGGGGATGTTCAGGTTGATGCCCGTCAGCACCTCGCGGCTCCCATAGGCGAAGGCCACGTCTTTGAACTCTATGTCGTACGAGGCGGGGGCTATATCGTCCCCGCCCTCGTCGAGGAGGGGAATGTCGGCTATCGAATCGAGGCGGTCGAGCTGCGTCGTGAGCAGCTTGCTCAGAAACGCCCCGTCGCCCAGGAGCTCCAGCTCCATGAAGACGATAAAGGCGCAGACGATGAACAGGAGGCAGGAGGACAGGGAGATGGTTCCTCGCAGGTAGAGCAATGCCGCTACCAAAAACATCAGGCAGCTTGCGATCTTGAACACAGCTTCGTACAGCTTCATGGCGCCCGCCGTCGCGTGCGTCACTTCCAGGTCGCTTCTCAGCTTGTTCTCGAAGGCTTCGTCCACCTTGCCTTTGCTCTCCCTGCCCTTCCCGAAGGATCGCAGGATGGAGATGCCCCGAATGTACTCCAAGGCACTGCCGACCAAGCGCTCTTGGGCACCCTGCATATCCTTCGTATGGGCTCCCGCCCGCCTTCTGATGAGGGCGAGGACGGCCGTGCCCGCCAGGATGCTCGCGAGGGAGACGAGCCCGATCGGCAGGCAGGCAAGGCAGAGCATCAGGGTCATGGCGAGAGCCTGTGCGAAGCCGCCGACGAGGAACGTGAGGGCCAGCATGCAATTGCCCTCCAAGTCAGATATGGTTGTCGTGAGCACTGTCTGGATGGTGCCCAGGTTGCCTTCCGTGAAATAGCCCATGGGGGCCCGCTTCAGCTGCTCGCCGATCTCGAGCCGCCTATCTCGGAAGATGTCGTACCCTGCCACGCTCATCGTGATGTTGGTAAGGTACTGGAACAAAAACCGGCCCGCGACACTTAAGGTGACGATGGTGAATGCCTGTCCTATAATCGTGGCGGTGAGTGTGTTGATGTTGGCCATGATCAGCAATAGGGCAAAGAAAGGAAGCGCAGCGCAACATGACTTTAGAGTACTGAATACTATGCCGGCAATCACGCGCGGCCGATATGCACCGGACAAGGCAAGTATTCTTTTGACGATAGCAAACATGCGGCCCCCTATGCCAACTCGGCTACGCTGACGTAGTCGTTCCAGAGTCGTTGATAGAGTGGGCAGGATGCTAGGAGTTCGGACTGGGTTCCACGGCCCACAAGCTTGCCGTGGTCGAGTACCAGGATCTGGTCGGCGCCCTGAATCGTAGAGAGCCGATGGGCCACCACGATGAGGGTCTTGTCGCGGACAAGCTCGCTGAGCGCTTGTTGGATTAAACGCTCGTTTTCCGGATCGGCATAAGCAGTGGCTTCGTCGAGGATAACGACGGGCGCATCCGCCAGGATGGCCCGGGCAATCGTGATACGCTGGCGCTCGCCACCCGACATTCTGTTGCCAGCATCGCCAGCATCGGTGTCGTATCCGTCCTCCAACTGAACGATAAAGTCGTGGCAGCACGCGGCCTTCGCAGCCAGCTCCACCTCTTCGTCGGTTGCGCTGGGCCTTCCAAGGCGGATGTTCTCGCGGATGCTCTCGTTGAAAAGGAAGTTGTCTTGGGAGACGTAGCTTATCGCGCCCGTCATCTGCCGAGATGGGATGTCCCTGATGTCGGCTCCCCTGAAAACGACACGCCCTTCCTGGGGATCCCAGAAGCCTGCCATCAGCTTCGCGATGGTCGACTTGCCGGAGCCCGATGGCCCCACTATGGCACAAACGGTTCTTGGCTCGACGACGAACGAGACGTCCTTCAAGACCGTGGCGTCACCGTAGGAGAACCATACGTGCTCGAAGCGATATGCCGTATCGTCTAGCGGAATGTCCTGCTCGGGGCGCTTCAACTCGGCCTTTTCGAGAAACGCCTGGATGGTGGCGAGGTGGGCGCGAACCATATTGAACTGCTCGGAGTATCTTGCCACGCGCATCAGGGGTGCGATGAATCCTATGGGAAGGATGATGCAGACAATAAAGGCCGGGAGGGAAGTCGACCCCTCCTTGTAGAGCCATGCGCCTACGGGAAGGGTCACGAGCAGGGTGGTGGGCATGACTGCCTGCGCCATCGCCGACCAGAACCAGCTCTGCCTCCACCAAGACAGGGTACTGTCATGAAAGGAGCCGACGGCCTCGCTGAACTTCCCATAGGAGGAGGTCCCTTGATTAAACGCCTTGATAACCTCGATGCCCCCCACGTATTCGACGAGGGTGCTGTTCATGGCGTTTTGGGAGCTCGTGTACGTTGCGCTCCTGCTCTTATAGTCGCGCATCATGCCCGCATAGCACAGAAGGCCGAGTGGGATGGTGGCAAGGGCCGCCAAGCCCATGCGCCAGTCGAGGGTGAACACCACCACGATGCAGCAAAACGGCGCCACAACGTTGGATGTTACCTCGGGCATGAAGTGCGCCATGGAATCCTCGAGCTTTGAGACGGTATCCACCATGAGGGTCTTGAAGTCCCCCGCGGGGGTTTCCAGCAAGACGCCCAAAGGAACGCGAAACATCTTTTCCGCTATCGCGCTGCGCATGTTCTTCAGGATTCGATACGTCGCCTTGTGCGACATGAGGGTGGAGATGAAGGTCAAGGCCAGCCTGAGCAGCTGACCACCTAAGGCGACGGCGAAGAGGGCGAGCGCGCCTGACGTGGTGGCCGTGCCATCTAAGAGGCTTTCGACCATGATGGCAACGGCCGCAAAGGGGAGCATCCCGAAAAGCTCGCCGCATATGGCCAAGACCACTGATGCATACAGATGTTTCGCATAAGGACCCGCATGGTCAAGCAGCTGGCGTACGGAACTTGAACGATGGTCTGCTGCGCCGCTCGTTTTCACTATGCCCATCCTTGCCACCATTATTATCCGTATCTTACTGAAAATAACGAGACCATTACTTCGCGGACAAGCCAAGAATGCCGTACCACCCGTAGTGATGGAACGTTACGATGCTCTTTATGTAGTCCTTCGCTTGTTCGTAGGGGATGTCGCGGACGATGCATTCGCATACCGCGCTTATATATCCACGTGTCAGCATATGCACTTCGGTCTCGCTTGGCCTGTGGGAAGCCAGGCCGGTCTCGTACGCAGCGTCGATGAAGGCCATATTCTGTGCCGCATAACGCTCTGAGATCGTTTCGGTGAAATCTTCCGCAGATGACCCCTGCGCACACTTCAGAAGCAGCCTGAACTCATCACAGTGCTCGTACATGTAATCGATGTAATCCATCACCTGGGCATATGTCTGCTCGACGGAGTCGGAGTCAAGTGCCTTCTGGATACCGGCGGCGTCGCACCCATCGCGGTCGAGACGGGCGACTGTGAATTCGGACACTTCCTTCACAAGTGTGAGGAACAGGTCGTTCTTGTCTTTGAAGTGTCGGTAGATAGCTCCGGTGGTCACCTGGGCGGCAGAAGCGATCGACTTGAGCTGCGCTGCCCTGTACCCCTTCGCAAGGAATTCGGCTTTCGCGCACTCCAAGATGCGCTCTCTCGTCAAATCAGAGCAGTACGTCACGCAGCGTCTCCCTTTGATAATCATACTATCTTTGATAAACCGGCTATCTTTATAGCATAGATTATCGAGAAAGTAAAGAATGGCAGACTCTTTGGGGTTTCTGACGGGCAGTTTCGCTACGCCTTAACATGGCTTGCTCGCGTCTTGATTCCTCGAAAAGATGAAGCGAGGTGACTCGAAAAGCGTAGTTGAGTTCGTTCGAAAACAATAGATGGGGTTTCTCTACATAGAGGGGTTTCCGGGCACGGCGGCGCGCAGTTGCTTGCATCAACGCCTCGTTCCGTACTCACCCCTGCTTTTCGCCTGCTCATTTTTGAATTTCAGCGTGGCAAGATGGGAGAGTCATGTACGCGATGAAGTACTATGAGGCTAATAGTGATGAGTTGGAAGGGGGGCCATGGCGAGGGGCGAGTCTGGGCACCTGCCCTATGCGGGCGTGGGCCCCCTCTATGTTGTCGCCATCATCGGGGTGACGGTGCTCGGCATAGCCTTGGGACAGCTCGGCCTGATCCCCTGCGTGGGCTGGCCGGTCCCGAACGCCGCACGTATTGCTCTGGGCATCGCGCTGGTCGTGCTTGGGGTCGCGATGTGGCTGGCGGCATTCTTTGGCGCGGGCATAGACGATGGGATCCGTGAGAACCAGCTTGTGACCACAGGTGTCTACGCGTGGGTGAGAAATCCGATCTACGTGGCCTTTGCCATGGCGTGCACGGGGGCGATCGTGATGGCGGACAATGTCTGGCTGCTCGCTCTGCCCCTCCTGTTCTGGGCGTTCCTCACGCTGCTCATGCGGCACACCGAGGAGCGATGGCTCCTGGATCTCCATGGTAGCGTGTATCGCGCGTATTGTGAGCGCGTCAACCGCTGCATACCCTGGCTGCCACGTCGGCGCTAAGGCCTGTCCGTCAAGGCGTGCGTGAAGCCAGCTCTCCTTGCAGCCACCGGTTGCGGGAGAAAGAACATCGTATGCCAGAAGTGGCGTTCGTGTCGGGTGTGGTCGAGCATGACACCATGCGGCCGTTAGACGTATGCCGACGATGACAGCCCATGCTCGCAGCCGACGATCGTCGCGCATCTCGCACGACGGGCGCTAACGTCACCGAGCCATTGCATGGACTGGTGGCGTAATGTGTGCGGCTGGTGGCAGGCGGGTGTGTCCGTTGTTGTCGTGGTCCCTTCGCTACTACAATTTCTCAGGCTGGCAAACGTAGTCGAGATCGTCCGCGTGCGCCACCCGAGCCGGCCACATGCGTCATGTCGTAACGCACATGAGAAGGGACTTCCGTGCCAAGCTTGTCAGATCAAATTGCCTCGCGGCGCACCTTCGCCATCATCTCGCACCCCGATGCGGGCAAGACGACCCTCACCGAGAAGCTGCTGCTCTATACCGGTAGCATACAGACGGCGGGCTCCGTCAAGGGCAAGGCGAGTGCGCGCCATGCGGTCTCTGACTGGATGGACATCGAGAAGGAGCGCGGCATCAGCGTGACCTCGTCGGTGCTGCAGTTCACGTACGACGGCTACTGCGTCAACATCCTCGACACCCCCGGCCACCAGGACTTCTCCGAAGACACCTATCGCACGCTCATGGCCGCCGACGCCGCCGTCATGGTCATCGACGGCGCGAAGGGCGTCGAAGCCCAGACCAAGAAGCTCTTCAAGGTGTGCACGCTGCGCCACATCCCCATCTTCACCTTCGTGAACAAACTCGACCGCGACGCGCGCGACCCCTTTGACCTCATGGAGGAGATCGAGACGGTGCTCGGCATCGGCACCTACCCCATGAACTGGCCCATCGGCAGCGGCCGCGGCTTTCGCGGCGTGTTCGACCGCGCCGCGCGCCGCGTGCTCGCCTTCGAGGGCGACGGCCATGCCAACGCCACGAAGCGGGTGGACGAGGTCGAGGCCGAGCTGGGAGACCCTGCCCTCGACGAGCTCATAGGCGAGGAGAATCACCGGAATCTGGGCGATGACATCGAGCTCCTCGATGGTGCCGACAACGAGTTTGACCTCGAGGCCGTGCACACGGGCAAGCTCACCCCGGTGTTCTTTGGCTCGGCGCTCACCAACTTTGGCGTGGGGCCCTTTCTCAGGGACTTCCTGTGTCTGGCTCCCGCACCCCTGGCCTACATGGACAGGCTTACGGGCGAGAAGGTGGACCCCTCTCGCAACGACTTCTCTGGCTTCGTCTTCAAGATCCAGGCGAACATGGACAAGAACCACCGTGACCGCATCGCCTTCGTGCGCATCTGCTCGGGCAAGTTCGAGCGTGGCATGGATGCCCAGCACGTGCAGGGCAAGCGCAGGATCAAGCTCGCGTGCGGCACGGCAATGATGGCCGACGATCGTGCGACGGTGGACGAGGCGTACGCCGGCGACGTCGTGGGCCTCTTTGACCCGGGCCTGTTCTCGATCGGCGACACCGTCTGCGCGGGCAGGCGACAGGTGGAGTATCCCAGCATCCCGACCTTCGCTCCCGAGCACTTCGCACGCATCACGCAGGTTGACACGCTCAAGCGCAAGCAGTTCATCAAGGGGATGGAGGAGCTTGCCCAGGAGGGTGCCGTTCAGATCTTTCGCGAGCTCGGTACCGGCATGGAGAGTGTCATCGTGGGCGTGGTGGGCGTGCTGCAGCTCGACGTGCTCGAGCGGCGCCTGAGGAGCGAGTATGGCGTGGAGGTCATGCGCCAGCCGCTTCCGTACTCGGAGATTCGCTGGATAGTCAACAGTCCAGACGACATCGACGTCGCAAGGTTGAATCTCTCTAGGGACACCTGCCGTGTCGAGGACATGCGGGGCGGGAGGCTCCTGCTGTTTACCAACGAGTGGAACGTCGATTGGGCCATCGAGCGAAATCCCGACCTCAGGCTCTCGGAATTCGGTAACGTCTCCCTCTCGTGAGTGGGTATCGGCACGGGTACATTGAGGGACTTTAGAATCATTTAGAGCTTCCACCTGCGGTTGCGAGATGACATACGAGCCCTTTGGGGACATTCGGGAACGCTTGTTTTCTCTGGATGTCCCCTTTTTGCGGCTCTTCGGGGTTTCTGGTGGGTAGCACGGGCTTTGCTCGCAACTATTGGTTGCGAGAAGAATTGCAAGCTAGAATTGGTGGTGCATGTGATGGGTGTGGTTGAGCATGATGCCATGCAGCTGCTAGGCTCATACCAACGACGACAGAGAGAGGTTCCCATCATGAAGATCGAGACAGCGAAGAGACTTTACGAGTATCGTCGGGCCTCCGGGCTTTCCCAGGAGCAGGTTGCCGCTAAGATCGGCGTTTCGCGCCAGGCGGTGTCGAAGTGGGAGTGCGCCGAGTCATCTCCCGACACTGATAACCTCATCGCGCTTGCCCTGCTCTATGGGGTGACGGTGGACGAGCTGTTGTTCGCCGATCCCGAGAGGGCGATTGTCGCAACACTAGAGCGTGAGACAGACGCAGATGATCCCGAAGAGGGCGCTGAGAGCGCGAGCGTCGCCGAGGGGGCGCCTGCGGAGGCAGGGGAGGAGTCTGCCTGGCAGTCCCCCGAGCATCCCGAGCAGGACTACGTCAACATCAGCTTTTCCCAGGGCGTGCACGTCCGTGACTCCAAGGGAGGCGAGGAGGTCCATGTGGGCTGGGACGGCATCCATGTGGACAGTGACAAGGAGCACGTGCACCTGAACTTCGGAGGTCTGGCCAAGATGATTCGCGAGTTTCGCAAGGACCAGGAGTAGCCCATGGATGAGGCCATGACCGACGGACGGCACATCGCACGGTACCTCATCATCGCATTCGCGATGACCTGGACCTGCTGGATGGCCCGGGCCGCCCTGTGCGCGAGCGGGGTGGCCACGGTGGACTCACCCGCCGTCCTGCCCCTCTTTCTTATAGGAGGCTTTGGGCCGACGGTTGCCGCGCTGGTGGTGAGGCCTGACGCACGGTCGCTGCACGGGTTCGCGCGGTTTGTCTGCGGTGGCTCGAGGACCTCCATCGGATGGCTTTTCCTGCTCGTCGTACTTGGAGCGCTCTCCATCGCAGGAAACTCCTCCGGTCTCAACGCAGCGATTCCCGCGTTCGCGATTCCGGTGATCTTCCTTGTCACGACGCTCATCGGCGGCGGCAATGAGGAGCTGGGTTGGCGCGGTGTGCTGCAACCCGAACTCGAGGGGAGGCTGCCCTATCCTGTGGCCACGCTCGTCACAGGCGTGATCTGGTCGGTCTGGCATGTGCCTTTCTGGCTCACACCAGGTGACTCGCACCTCTCGTTCCCGTTCCTGCTCTTCGCCCTCCAGGCGGTCCTTTTGTCCTTCTGGCTTGCCGGCCTGCGCAGGAGGGGCGGCTCCGTCTTGTGGTGTGCCGTGCTCCATGGGGCCATGAACACGCTCATGTCGGCGTTCGTCCTGCAGCTGAATGCCCCGTTCGTCATCGGTATGCTCGCGATCACCGCCCTGTCGATCTGGATGGGTATGGCGGCTCAACGGGACGACAGGCGTGCCTGAACGGGGATTCCACCGGGGTGGGGCGACGGCTTGCCGTCCCGCCCCGGTTACGGTCCCGCCCCGGTCACGCATGCACCCTGTGCTACAGGTTGGCCTCCATCGTCTTCACGAGGAACTCTGCTCCGCCGTTGCCGGCTGCGGTGTCGTAGTAGTTCTTGAAGCGTGGGTCGCCTAGGTATCCGCGCACCAGCGCCAGGTGCACCTTGCGGTCGTAGGACTTGCCCCAGTGGATGCGCATCCAGCGCTCGTGCATGTGAGCGAGCTCAGCGGCTTGGTCACCCGTCGGGTCGCCCGATGCCATTGCCAGGCGCAGCTGTACCTTTATGGCCTCCTCAAGCAGGTCCTTCGCGTCCCACTCGTCGCGCGTGAGCGACATGATGCGTTCGTTGGCCGCGTCGATGGCCTCATCGCCGTAGCGCCTGCGCGCCTCGGTTCCGTACGTATCCTCGAACTCCTTCAGTCCTTGGGCCTTGATGGCCTCGAACCTCTTCTCGTTGTCCATGTTCTCGATCCCTTCGATAGTCGCGATAGCCGCCTTTGTGCGGGCCATCGCGTCCGACAGTGACTTCTTTTGCGCGCGCAGGGTCCTGAGGTGTGACTCAAGGGTGTCCCGGAGGCTTGCCTGTGAGTCCCTGAGCAGGTGACGGATGGTCGTGAGGGGAAGGTTGCAGGCGCGCATCGCAAGGATCTGCGACAGGCGTCTTGCGTCGCGGGGACCGTACGTGCGGTACCCGTTCTCTGCCCGGGCGGGCTCGAGGAGCCCCATGTCCTCGTAATGGCGCAGCGTGCGTGCACTCACGCCCGCCATCTGGGCCAGTTGTCCCACGCTGTAGTGTCTTCCCGCAGGTTTCGATTCGTCCATCTCACACCTCCAAGGGCATCATGGACCCTCACGTAGCGAGAGGGTCAAGGAACTTTACGTGACGAGAAGGCTACGGGGGTGCATGGGACTTGCCATGGGCGAGTGTCGAGGAAGTAAGCTATATCAACAGCCCTCGTGCAATATACACAAGGCAATCACACGCTAAGCATGGCATGCTCCCGTTGATGGAAGGTGAGGACGGGAGGCATGGCTTGGTGGGGCCGAGGACGGCGCTCGATCCGGGCGCGCGGAGGTTCCGACCACGCCGGGCCGGGGATGTTCTCGCGGCTCGTGGGGTATCGTTTGGGCTAAGTGTCACGATCCTGCCAAGATTCCGGCGCACTGTCGACCGCCCGGGCTCGTCGGGCCCTTGAGCGCCTCCTTACCCAGCGTGAGGCTGGTCTGCTCGCGCCGGCAGTGAGTGCGCAAGGACAAGCGCGACCTGGTCGAAGGAGGGGCCGAGCGCGCGCTCGAAGAGCTCCCCCTTGCCCGCGAACAGGAAGTAGAGGGCATCTGTCGTCACATGGGCCGCCGCACAAATGCTGCGCAGCGACGCCCCTGGCAGCCACGCTCAGCAAACTCCCGCGTCGCCGCAGCGATGGGGGTGCGCCTCGTGTCGGCGCTCTCCTCCCTCGTCCGTCTTATGTGGCTCTCCCAAGCGCGGGCGCGGTGCGCGCTGGCCCTTTACGCGAGCATGCGCTCGACCTCGTCGGGGTCGAGCCCCAACGACGCCGCACCAGCTCGTGCGTCCACGAGGCCGGCGCGCACGAGCTTGCCGCCGTGCGCATTGGTCTCCGTGAGCACCCTCATGAGGGCGGGCGTCGCACGGTGCGCTCATGTGCGGACGGGTTTTGCCGAAGCCCCGACTGCTTCCGCTCGACCACCGTCGCCTCGCGCACATCATCCCCCCGCAGCCGACCTCATCCCTCTGCCGCGAGCGCGCGCCTGATCTCGTCGGCGTCCACCCCCACCGAGGTGGCAGCGTCCTGTACGCTTACGAGCCCGTCGCGCACGAGACGGACGAGCGTCTCGAGCTTGCCCTCCGCGATACCCTCTGCGCGGATCTCCTCAATGACGCTTCCCATGTCCTCTCGCCCCTCCTCCGTCTCCCTGAGCCTGCGCTTCATCCTGGACGTCTCCGGGAAGCGCTCCTCTTCGTACGCCTCGGTCTCCGTGAGCACCCTCATGAGGGCGGGCGTCGCACGGTGCGCTGGTACGAGCTGGCCCTGCCGAGCTCCCGACTGCTTCCGGCCGCCGATGAGTCGAGCACGTCACCCCCGCGCAGCCGACCTCATCCCTCCGCCGCGAGCGCGCGCCTGATCTCGTCGGCGTCCACCCCCACCGAGGTGGCGGCGTCCTGTACGCTTACGAGCCCGTCGCGCACGAGACGGACGAGCGTCTCGAGCTTGCCCTCGAGCTTGCCCCTCTCCTCGCCCTCCGCGATGCACTCCGCGCGGATCTCCTCTATGACGCTTCCCATGTCCTTTCGCCCCTCCTCCGTCTCCCTGAGCCTGCGCTTCATCCTGGACGTCTCCGGGAAGCGCTCCTCGTCGTACGCCTCGGCCTCCGTGAGCACCCTCATGAGGGCGGAGACCTCGCTGCCGTCCCTCGCCAGGGCGTTCACGTAGAGCTCCTCGAGGCCGTTCTCGGCCGACTCGCCGGTCTCCCTGACGACCCTGTCCACATGATACAGCGGCCGGCCGCCCCTGAGGGGGTCGAACTCGCAGACGAGCACGACGCAGACGTCCGGGACGTCCCCGAAGGGGGTGCCCGGGCGCGTCCTGTCCGCCGTCACGAGCGAGGCGTAGTAGCGCGCCCTCCTCTGGAGGTCGCCCTTGTCGGCGCGCTGCACCTCGACGTCCACGAGCCTGCCGTCGGAGAGCTCGCAGAGGGCGTCGAGCACCGCAGAGCGCCCCCGCGTGTTCGTGACGGCGGACTGCGGCTTGCACTCCACCACCTCGAGCCCCGGGTCCTGGAGCAGCACCCTCAAAAGCTCCCCGCAGAAGGCCTTGCTCTGCGCCATCACCCGAAACATCAGGTCGTCTATGGGCCTCAGCTTGCCCACGTCACGTACCGCCCGTGCCATCCGACCACCGTCCCCCACTCGCCGCCGTTTCTTGCCACTCACTATAGCACAGGACTGGAACGCATGTTCTTGTCAATACAAGAGTATGGATACTTCGTGAATCCCCGTAGATTATTTTTCATGGGTTGGTCAGTAATGCTTCCTCGGGCTGGCGCATCGGATTCCGCTTGCGGTCCTGTCGAAGGTGGCGGATGACTTCTCGAATACGTCCCCACATGCTCCGCATGTCGCCTGTCGGCGCGATACCTTCTAGACATGGTTGAGGTTGTTGTTGCTCCCGAAGGCCGTGGCGGTACACCGCCCTCGTTTGGGCATGCGGGCCTTGCGCTCGCAGACCGAGCTGCCCGGCCCGGAGCGCATGTCGTGCGAAAACGGCAGATGGCTACCGCAGTCGTCGTGAGTCGTCGCGCATACGCACGGAGTGTTTTGGTCCAATGGGAACCGCGCAGCTGGGACTGCGGTGGGAGTCTTGGACCAGCGTGCTTCGTGGGATGCCAGCACCGGGTCCCGAGTGCCACGGCCCTGTTAGGACATGCTCCCGTTGTCGCCTCTCATTAACGGGAGCACGTCACACATAGCATGTAAATACTTTATGGATACAATGCTAGTGGTGGAAGAGCCGCGTTCCCGTGAAGCACATCGCGATGCCGTATCTGTCGGCTGCCGCGATCACGTCGTCGTCGCGGATGGAGCCGCCGGGCTCCACGATGTAGGAGACGCCGGACTTGTGGGCGCGCTCGACGTTGTCTCCAAAGGGGAAGAACGCGTCGGAGCCGAGCGTGACGCCGTCCTGCGCGGCAATCCACTCGGTCCGCTCCTCGCGAGTGAGGGGCTCTGGTCTCTCGGCAAACCACTGTTTCCACGCGCCCTCGGCCAGTACCTCGTCCTGCTCGTCGGAGATGTAGACATCGATGACGTTGTCGCGCTCGGCACGCCGGATGCCCTCGGCGAACTTGAGCCCAAGCACCTTGGGGTGCCGACGCAAGAACCATGCGTCGGCCTTGCTGCCAGCTAGACGCGTACAGTGGACGCGGGACTGCTGACCCGCGCCAATGCCTATGGCCTGGCCGTCCCTCACATAGCATACGGAGTTCGACTGTGTGTACTTGAGCGTGACGAGGGAGATGAGCATGTCCGTCAGTGCCGTGTCGGGCAGGTCCCTGTTGGCGGTCACGACGTCTTTCAGTAGCGAGCGGTCGATCGCGAGGTCATTGTGGCCCTGCTCGAAGGTGACGCCAAAGACGTCGCGCTGCTCGATGGGCGCGCAGCGGTAGTCGGGGTCGATCAGCACGACGTTGTACCTGCCGCCCTTCTTGGAGCGTAGGATCTCAAGTGCCCCATCGCTGTAGCCGGGTGCGATAATGCCGTCCGAGACCTCGTGTTTGAGGTATCTGGCCGTGCGCTCGTCGCAGCAGTCAGAGAGCGCCGCCCAGTCGCCATAGGAGCTCACGCGGTCGGCGCCGCGCGCGCGGATGTAGGCGCAGGCGATGGGGGAGAGCTCTCCCTCGTCGTCCACAAAGTACATCTGCCTGTCCACATCGGAGAGGGGCCTGCCCACGGCTGCACCGGCGGGCGAGACGTGCTTGAACGACGCTGCGGCGCTCTGTCCTGTGGCCTCCCTGAGCTCGCGCACGAGCTGCCAGGAGTTGAGGGCGTCTAGGAGGTTGACGTACCCGGGTCTACCCGAGAGCACTGTCATGGGCAGGTCGGAGCCGTCCCTCATGAAGACGCGTGAGGGCCTTTGGTTGGGGTTCGTGCCGTACTTGAGCTCGAGTTCGTTCACAGGTTCTCTCCCTAATCCTCGCCCTCAGTCACCGAGGTTCTTGTTGTACAGCTTCACCGTGCCCCCGACGTTGGCGTAGAGCGACACCTTGTTGTCGGCATTGAGGGCGACCCACAGCTCGTTGGCTGTGGGCAGGCTCACCTCCACCGGCTCGCCGACGAAGCTCGGCAGCGGATCACCGTCGCCTTGGTAGGTGCTGATGAGGTAGCCCGTGCCCTCGTCGGCGCCCTCGTAGCAGAAGAACTCGCGCTGGCAACGGCCAGAGGCGCCGGCCTGGCGCTTGAGGATGGAGAGCTCAAAGGAGCCGCCTGCGTGCAGGATGGCCGAGATGCGTGGCGTGAAGTTGGGGTCGTCTGGCTCGAACTCACGGGCCATACACGCCGCAAAGAAGTCACCTGTGTCCACGATGGTGTCGGTCTGGTCACCGTTTGTGACCACAAGGTCGTCTCCCATGCGGCGCACGGGGTGGTAGATGATGAGGCTTGCGTCCTTGAGGAGCGCGGGGTCGTGCGCCTCTGTGCGGATGCCGTCTGCTGTCAGCGAGAAGACGCGGTTCCTGCTGTTGGGGCTGCGGCCCATAATCCAGTAGTACGCGCAGTGCCTTCCTCCCCAGTCTTTGCCCACCACGATGCCGCGACCGGGGTAGGGGTTGTTCCTCAGGAGCTCGCATAGGTCTTGCATCAAAGGTCCCCTCTCGTCCGTCCCCTGCGCAGCAGCTGTCGCCCAGACGCTCGCAGCTGTGATAGAAGGCCCACGTCGCGCCGGAAGAGGTCTCCCGATGCCCTGTGCGCCGCGTCCCGCGCGCCGCCCAACTGGTGCCGGACGACATCGCCCGCCGCCCACAGGTATTCTATCATGCTTCTCTCGATTGCTCGCCAGGCCCCGCCGTCCTCGTGCGTCACGGGACCTGTGGCGCCCTTTGCACGGCAGCCTCTCGCGGATGTACCCCTGTCATGCCACAATCATGGGGTGGAAAGGCCGATGTCGCCACCATATAGTTCGAAGACTCCCTGTCAGGAGATGATGCGAAATGCCTTTCCCCAAGAATGAAGTCCGCAAGGTGTGCATGCACGATACCCGAGCGCTTCTGTGGGAGCGATCACACAGCAGATGCTTCGGGTATCTTTCCGAGATCCTCTCCAGCGATCTTATGATCGCAGGTAATACACCTCAGCCAAGTCGCAGGAGCACCCAACGAAGCAGTACGTGGGATAGTGACGCGCACCGTGGTGGCACACAAAGCGCGTCCTTCCGTGACGTCGCTGGCTCAGAATGCGCTTTTTCGTCGACCCGCGATCCCAGAGTGCGCTTTTCCGTAGAATGCGCCTTTTCTGACCTGCGCAAACGTCGAGTCGTCTCACGGAAAACCGCATTCTGTGCGTTGGGCCTCACGTAAAAGCGCATTCTGTCCCCGGGCCTTCACGGAAAACCGCACTCTTCACCCGCGTGGCCTTCCAGAGTGCGCTTTTCCGTTGACTCCAACCCCCAGAGTGCGCTTTTCCGTAAAGTGCGCCTTTTCTGACCTGCGCAAACGTCGAGTCGTCTCACGGAAAAGCGCAGTCTGCACGTTGAGTCTCACGGAAAAGCGCATTCTGCACGTTGGGCCTCACGGAAAAGCGCATTCTGCACGTTGAGTCTCACGGAAAAGCGCATTCTGCACGTTGGACCTCACGTAAAAGCGCACTCTGGCCCAACGTCTCACGGAAAAGTGCAGTTTGCAGCCCCCACGTCGCGCAGACTGCGTCTTTCGGTCACGTCGCCGCCTGGGAGGCGTGGGGCGCGCAACCCCCCGCCAGGCTGCGGGGCACTATGGAAAATGGCCCAACTGGGCAAATGCGTCCGAGCAACCCCCCGCCAGGCTGCGGGGGGGGGTTGCGCCAGAGTCCGCAAGCCTCGGTTTGGAGCCTGACTTCTGCCCGGGTGGCGCCGATAAGGACGGACACGCCTCGTGACGCTATGTTTCCAATTCGGTGAAACATCGCCTTTTGCGCCGTTGGGCTACCTCCCTGTGCTAGTCTTTGTCCATCGTGCATGCAGCAATATGCATATATGGGGGACACAATCCAATGGCGCCTGCGGCCCACGGGCTGCGGGACCAAGGTGTCGGAAGCGAGGCAGGATATGAGCTATGCAAGGAGAGGGGCTGCTCATGAGCGGATTTGAGCCGCTGCGCGTACCTGAGCGGGACGGTGCGGCCGAGGGCTTCGGCTTCGTGCCCTGCGAGGGCGGCGTCTGCGCCGCCAGGGGCATCCGGGCCACAGGCGTCTCTGCGGGCTTTCGCCACAATCCTGACCGTCGTGACCTCGCGCTCGTCGTCGCGGACAGGACCTGCGTCTGTGCGGGCACTTTCACCAAGAACCGCTTCTGCGCGGCGCCTGTGCAGGTCTCGCGGCCACGTGCGGCCTCGGGCCACGCGCGTGCCGTCGTCCTGAACTCGGGCAACGCCAACGCCGCCACGGGCGAGCAGGGCCTTGAGGTTGCACGCGCATCTGCGCGCATCGTCGCGGACGCCCTGGGCTGCGCTGCCGAGGAGGTGCTCGTGGCCTCGACCGGTGTCATCGGCGTGCCCTTGGGCCTGGAGTGCTTTGAGATGGGAGTGCCCGCCTGCGTTGGGCAGCTCGAGCGCTCGGTAGCGGCCGCCCACCACGCCGCCCGCGCCGTCATGACGACGGACACCCACTCCAAGCAGGCCGCCTACGTCGGCAGCCTTCCCGCTCCAGGTGGCGGGACCGTCGAGGTCCACGTGGGGGGTTTTGCCAAGGGCTCGGGCATGATCCAGCCCGACATGGCCACGATGCTCTCGGTGCTCTCCACAGACGCACCGCTCACGCCCAAGGCCGCGCGGGTGGCCCTGGGGCGGGCCGTGAGCCAGAGCTTCAACAAGGTGACCGTTGACTCGGACACCTCCACCAACGACTGCTGCATACTCTTTGCCACGGGAGAGGCCGAGCTCGAGGCCATCGACGAGGACTCTGCGGCCTTCCCTGCCATCTGCGCCGCCCTGCGCGCGACCTGCGAGGCGCTGGCCCGCCAGATCGCGGCCGACGGGGAGGGCTCGACCAGGCTCGTGACCGTCGACGTCATGGGGGCGGCCACCGAGGCAGACGCCGACGCCGTGGCCCGCGCCGTCGCAAACTCGCCGCTCGTCAAGACCGCTGTCTTCGGGCACGACGCGAACTGGGGCAGGGTCGCCTCCGCCGCCGGAAAGTGCGGGGTGGCCTTCGACCAGCGCAAGGTGGACATCGACCTGCTCGGCGTGCCTGTCTGCCGCAGTGGCCTTGCCGTGGCCATGGACGAGGACGACATGCTCAAGCGCTTCAAGGAAAGCGAGGTCCCCATAGCCATCGACCTGGGTATGGGATCGTGCTCCACGCGCGTCTGGACCTGCGACCTCACGCACGACTACGTGACCATCAACGGGGACTACCGCACCTAGGCGCGAGCCGCAGGTGCAAGGTCCCTGACAGGAAAGGTTGGCTGACATGGTGATGAGAAGGCGCAGGCCCAGCGATGCCTCGCAGGGCAAGGCTGAGGTGCTCGTGGAGGCCCTGCCGTGGATCAACGAGTGGGCGGGGAGCACCTTCGTGGTGAAGTACGGTGGCTCGGCGATGGAGGACGCCACGCTCCGGGCGAAGGTCATCGAGGACGTGCTGCTGCTCAAGCTCATGGGCGTGCACGTGGTGCTCGTACACGGCGGCGGCAAGGACATCTCGTCTCTGAGCGACCGTCTCAACCTGAGCGTGCGCTTCAAGGACGGTCTGCGCGTCACGGACGAGGACACCATGGAGGTCGTGCAGATGGTGCTCGTGGGCAAGGTGAACGCCGAGCTGGTGCAGGCCATCAACGGCTACGGCAACCACGCGGTGGGCATCTCGGGCGCCGACGGCCGCACGCTCAGGGCCTGTCAGCTCGATCCCGAGCTAGGCCGCGTGGGCCGCGTCACCGAGGTTAACCCAGACCTCGCCCTCAAGGTTCTAGATGACGGCTACATCCCCGTCATCGCAGGCGTGGGCTTTGGCGAGGACGGCGGCCCCTACAACGTCAACGCCGACTTCACGGCGAGCCACATCGCCCAGGCGCTCGGCGCGGACAAGCTCTTCTTCCTCACGGACGTCGATGGCCTCTACGCCGACTTCGACGACAAGGACAGTCTCATCGCCGGCATGGGTGTAGGGGAGGCGCGACACCTCATCGATGCGGGCACGCTCAGCAAGGGGATGATCCCCAAGGTGAGAAGCGCCATCGAGGCCATCGAGGCGGGCGTGGGCCAGGTCACCATCCTGAACGGCACCGTCGAGCACGCGCTGCTCGTCGAGACGTTCACCGACGAGGGCATCGGGACCGAGATATCCAACGACTCCCGCAACCCCAAGGAGGCATAGCATGTACGAGTTTGACACACACGCGGACTTCATCGCAGGGGACGAGCGCTACCTCATGCACAGTTACGCCCGGCTGCCCGTGAAGTTCGTGCGAGGCTCGGGTTGCGTGCTCACGGACTCTGAGGGCAGAGACTACCTGGACTTTTTGGGCGGCATAGGCGTGGTGTGCCTGGGGCACTGCCACCCCAGGCTCGTGGACGCCCTCAAGGGGCAGGCCGAGAGGCTCTGGCAGGTGGGAAACTACTTTCACGTCGAGAACCGCAGCGAGCTTGCGGCTGCGCTCTCGCGCCTGCTTGGTGCGACCACCGACGAGGAGGGTCACGTGACGGGCTCGACGGGCCAGACGTGGAGGACCTTCTTCGCGAACTCGGGCGCCGAGGCGAACGAGGGTGCCATCAAGCTCGCGCGCCGCTGGGGCGAGCGTAGGCTCGGCGGGGCCACGGGCATCGTCACGGCCAAGCGGAGCTTCCACGGCCGTACGCTCGCGACCTTGGCGGCGACCGGCCAGGACGTGTTTCATAAGAGCTTTGCGCCGATGCCCGCAGGCTTCATGTCGGCGGAGCTCAACGACCTTGCCGCCCTTGAGGAGGCTATCGCTAGGCCCGAGGCAAGCTGTGGTCCCGTCTGTGCCATCATGCTGGAGTGCGTCCAGGGCGAGGGCGGCGTCTGGCCGGCCGACCCCGAGTATCTGCAGGGAGCCGCTCGCCTCTGCGAGGAGCGGGGTCTCGTGCTCATCGTGGACGAGGTGCAGACCGGCGTCTTTCGCTGCGGCGCGCCCTTCTCGTACCAGCTCGCGGGCATCGTGCCGGACATCGTGAGCATGGCCAAGGGCATCGCGGGGGGCTTTCCCATGGGCGCCTTCTCCGCGCACGGAGAGGTCGCCGACCTGCTCGGGCCGGGAGACCACGGCTCCACCTTCGGCGGCAACCCGCTTGCCTGCGCCGTGGGCCGCGCCACGATGGAGACGCTCGTTGCGGAGGGCATAGGCGAGCACGTCATCGAGGTGGGAGCACAGCTTGCCGAGAGGCTCGCGGCGCTGCCGCACGTCACTGAGGTGCGTGGGCGCGGCCTCATGCGCGGCGCCCAGCTCGACGCGCCCATGGCGCGAAGCCTCGTCGAGCAGGGCCTGCGCGCGGGTCTCGTGCTTAACTGCGTGGGCGACTCGACCCTGCGCTTTTTGCCGCCGCTTGTCGTGACGGCAGGGCAGGTCGATGCCATGGCCGAGCGCCTGGCCAAGCTTATGGGGCAGGTGGCGTAGGGGCGCTGGCCGGGCGGGTCATCAAAGGTCATTGAGGGCAGCGAATGGATCATCGGAAGACGCGGCAAAGCGCCGGAGACAGGGGCGTCGCATCCCGTTCCAGTGTCCTCATCCATCAAGTGACGCTATGCTATCTGATATCAAGTATGGTGGAGAAAGGTGCTGTCAGTGGCAGATAGGATAATCCAAACGGCAGATTTGACTACGATCGAGAACAACCTGACTTCAATGCGTCGTGCAATTGAGCAGGTTGACGATTCCGTCGCTAACGTTAACCGTCAAATGAATGGCGTCGAGGTTCGGCTTGACGCGCTAGCAAGCGACTTCCGAGACTATGTCAATAATGAAATGCGACGTTGGGAACTTGAACACGCAACTACAAAGCTTAATAATATCAGACAGCAGCTTGCTGTAAAGTTTGGGCATTACTCGGAGGTGAGACGAACCACTACAGGAATACTCCAGGCAACCGATCTCGGTATTGTCAGGAATGCAACGATTACCAAAGCCTCCGAGGACCTTATGCTGAAGTGTCCCGAGTATTGGCTTGCTCCTTGTCTTGTGGCGCTCGCAGCGTGGATCAATGATGAGAAGGACATTGCCAAAAAGGCGCTCAAGGAGGCCATCCATCGCAATGATGAGAAGGCATCTCTGCTATTTGGGCTCATTTGCCGTCGTGCCAATAGGCAAGGGCCCGCACTCGAGTGGGTGAGGCGGTATCTTGCCAACCAAGATCCCGAAGGACTTGGTAGGGAAGCCATCATCATACTTGATGCGTATGCCACAGGTCTCTTCTCGGCCGATTCTGAGGGAGCGATCGCAGGCCAACTCAATGATTGGTGTGATCTGCTCGCCTCCCGTCCGGGGTTTCTTGAGGAGCAGACCAGCCGTTGGAAGACTGCCCTTAAAGACAAGCGCAAGCCTGTCGATCCAACCAAGTACCCTTACCTTCGCAAGTACTCGCACACATGGCCTATCCTCGAGGATATTCTTGAGGGAGCAATGGCTCATCAGTATATTCTAGCATATTTTAAGGATATCTTTGCACAGCAGCCCTCACAGGATGTCGTGAGGAAGCAACTTGACGATATTCTAACTACTCTTGTCTCTGAGTTCGATGACGAAGAGCTTCCGCTCAAGCGCGAAGAGCGTCTTTGTGAGTTGATTATCGAACACGAGGGCGATACCCAAGAGGCGCAGATATTGGCGGATCACGAGAAGACCTCCATGGAGGAGCAACGTGATTTTACCCAACTACTGACCGATGCAGCGATGTATCCCGATATCTCGCGCTCAAGTGTCTCGTCTCAGCAGTTTGCAGTGGCGTATTCACGCGAATGGATTTGCAATGGCTACAATGATATGGTTGCCGAGAATCGCATGAAGATTCCAAACGACATCGAAATTAACATCGACAGCTTCAATGCTGTCACTTCCGCTGGCACAGATGAGGAAAACCTCGTCAAGGCCTTTGATGAGCTGGTCGAGTCAGAGCGCAGTGCTGAGTTAGATAAGACCGTGCTTACGCCCTTTGAGCAAAACTGCCACTATGCTGGTATCGCATGCATCGCTTTCGGTCTTATTGCTCTTGCTGCTAAGCTAACATTCTTTGGAGTTCTCTTATGTATTGCTGGAATTGCTCTTGTATATAAACATTACTCACAGGAAAAGAATATAAACTCTCACCGTGATGTGATTAATTCGAACTATGACACAAAAAAAGAAAATGGTACCAAGCTGCTCAAGGCAACGATTGCCGAAATCGTTGACTTTCGTATCGAGTTTAGTCAATATGATGCCGGAAGCCAAGAAGTTCTTGATATGCTTAACGAGCTTTCACCTGATGAGTACGTGAGGACCCTTACCGGCGTCACACGTCACATCGTCTCGGCTACTCATTGAGAAGGGGGATGAATTTACGTGTTTTGCCCTATGTGTGGGAAGAAGAATCGTGACTCCTCTAACTTTTGTGCCAGATGTGGCGCATCGTTGAAAAGACTTGGTGTTCCTGCTTCGCGCGCGGACGCGGCCCCAGAGAGGGGCGGGAGCGTGGAGGCGCCGGCCGAGCAGGCGTTTGCGAACGTAGTTCCAGAGGTGGACAGCGTCCCGTCCAAGGAGGTCGGTGAGGTAGCCGAGCGTCAGCAGGACATTTTGGTGGACGCGGCCCCAGGGGGGAATGACGCCCCGTTCGAAGAAGTCGCTGAGGTAGCCGAGAGCCAGCAGGAGGTGATCGCTGACGTGACCCCAGAGGGGGGCGGGAGTGTGGAGGTACCGGCCGGGCAGGCGTTTGCGAACGTGGCCCCAGAGGGGGATGACATTCCCGCAAAGCCCGAGCAGGCCACACCAGAGCCCAATCACATAGCAATGGCCGAAGAGACGGGTCCGTCCTTACCATTCGAAGCGATCTCCGAGCATACCGAGGATGCCTTTGCTGCAGTGGCCGATGAGGCCAACGATATGGATACGCTTGCACCTAAAGGCACTGCAGGTGACCCAAGTCCTGCCGACAACGGTGTCGGCAGGATGTTCGCGAGTGTCGACGTCGGCACGTTCGTCAGCCCACGCCCGGTCAACAACGACGTCGGCAAGGGTAACGAGAGCGTTATGGAAGCTTATCCAACATTCGCGCAGGGTTTACCTGATTGGGATCTGACTCCCCCCAGTAGTATGGTTATTCGACATGTTAGGATGGCTCAAAAATGAGAAGCCCCCATACATATGCAGAGTGGGTTGAGGTTATCGACATATTCGGCAATAGGCTTGACGACGATGGCGCCATCTCGGCCATGCGTTCGGGAACTCTCGATTGGCAGGCGGGTGTATCGGATAGGTTTCTTCAAAAGCTTATCGGTGCCGTCAACAAGAGGATGAACGCCGCAGTAGACGCCTTTCAAAAGAGGCAGAGGCGGTCGGTGGCTGACGAGAGATCAATAACCGAAGCTTTGCTTGCGTTTCGTCGAGAGTTCATCACCTTGATGAATGCGGTGGATATTCCAGCTATGCCTGAAAAGTATCGTGAGGAGTGCCGATCTCTCATCCGAGGCCAAGCTGATGCCAATCAGTCAAGCCTCGAGGACTCTGCACCCAGAGTGGACAGAAGCGGCAAGCTTCTTTCCATCATCCATAAGACTCCAGTTAACAAATTCTGAGGTAGCCCGAATGAGCAGCAAGCATGAGACGAGGGACTTGTTGGTGCGCTATGCGAAGGCCCGCATCCCTCTCATAACCATCAAGACGGATGAGAGAAGGCGGGCTATCGAGATCTTGACCGAGGTCGCCGAAGAGCTTGGGGTCAAGGTATATTGCCACACCAAGTCAAAGGGGATCTATGACGTCACATCCATGCAGACCGTCTGCGATGGGGAAAGTGTCTACGAGGCCTTTGATTTCATGCGTGAGCAGATGAAGAAGCGTAGCCAACTTACCTTCGCGTTGTCAGAGACGGGGGACATCTCCACCGAGACGGGAGATGCCCAGGATCTCTACGACCTCGTGCAGTCAGCAGTTGATGCCTCAACCACCATCATTGTGATCACCAACAAGGACGTGTGGGGGCAACTCCAGCAGACGGGGCTCGTAGTCGTTCTGGACCGTCCCAACGAGGAGGAGGCCTATGCTGTCATCAGGGGTCTGATCGATCAATACCGGGGTAGCATCCCCATTGAGTGGACGGATGAGGAGGTTCGTGAGGCCGCCAGCGCATTGGCCGGGGTCTCCCAGATCGAGATCGAGAATACAATCGCCTCCCTTATCGCGAACGGGCACATTGGTGAGGATGATCTCGTCGAGATCCGCGGCTCAAAAGACAAGCTCTTCTCGAACATCAGTGGACTTGAGAAGATACAGACCAGTAAATCCGATGCAGAGGTCGGTGGCCTTGCAGCCTTGCAGGAATGGTGCAAGGAAAAGAAGGAACTGCTTACCCCCGAGAAGCGCGACGCCCTTCTCAAGATGGGGTTGAAGCCTCCCCGCGGGATTTTGCTTGTTGGCGTCCCGGGTTGTGGTAAGTCCCTCTCAGCGAAGTCAATTGCGTCAAGTTGGAAGTTGCCCCTCTATCGCCTTGACTTCGCAACCGTTCAGGGTTCCTATGTTGGCCAAACCGAGAGGCAGCTCAAGGAAGCCTTTACTATGGCGGAAGCCGTCTCACCCTGCGTTCTCTGGATCGATGAGATCGAGAAGGGGTTGTCTGGTGCCACCGCGTCAGCCGGCGATGGCGGCGTGTCCACTAGGATGGTCGGCCAGTTCCTGTTTTGGCTCCAGGAGTGCATGAAGATGGTGTTCGTCATTGCCACCGCGAACAACGTCTCACAGCTACCGCCCGAGTTACTCAGGCGCGGGAGATTCGATGAGATATTCTTCGTCGATCTACCCACCACCGAAGAACGTCAGTCCATCATGTCACTCTATATGAAAAAGTACCTGAGTCTTAATTTCGCAGGACCCCTTGCCGATGAGCTGGTGGAGCTTACGGAGGGATTCAGCGGGGCGGATCTTGAGTCAACAATTCGAGATCTGGCATATCGGAAGGTCGCGAATCCCCAGCTTTCCATTACTGCGGATATTATTAGAAAAGCATTCAACAATGTTGTTCCCCTGTCGCAAACCAGTCCCGAGCAAATCGAGTCGATTCAAAATTGGGGGCGTGAACGTGCCGTCCCTGCCTCGGGCAAGCCAATCGGATCACATCCTCTCCAAAGGTCTGAGGGGCCGCGCGTTCGAGAAGTCCTCATATGAGGGAGTCAGCTTGGTCGATCGTAGGGCTTCCCTAAGCCGCATAGATGCACTCCCAAGACTCGTTGAGCTTGATTTCGCTCCGCGAAAGTCCCGGCCAGCTCGCTACGTACGCGTCAGGATAGCCGCACATTTTGAATCAAGGAGAAAGGAAGTATCCAGATGCCACGCCAGCTACTTAACGTTCATGCAAACAGTAGACGACAGCAGCAACTCGATGTGCAATCTAGCTCAAAAAAGGCTCAACAGAAAGTAAATCCCGTCACATTTGAGCGTGCACTTCGCAAGCATCGATCGAAGCGCTACATCGAACTCATGAAAAAGCTCGACGCTGGGGGACACGTTACCAACCAACAGCAGGTCAATTACTTGATCGCAGCGCTTCGTAACGAGCTCGGAGAGCTTGATGAGAGCCTCTCAGACTCTTTGCGGGGCATTGTCTCAAAATGCTATCTGGGTGATCCATACGAGGTTCATACGCTTGATGTGGCCCAATGCATAATTGACCATTACGCGCGAGGCGAGCGCCTTCCTGGCACGCTCGAGAAAGTTCGAGGAATCGCCATGCTGGGCGGATATGACTTCATCGAGGTCTACGATGGCTATTTCTGCGCGGTAAGCGATTCTGGCTCTGTGTCTGTGATCAGGGGATAGGCTCCATCATCACTGGTCCTCTTCGATCGTGAGCCGGTGCGCATCACGCGCATCGGTACGCTGCCTTGGGCGGCAGACGGGAGATACACGCAAGAGCGTCACCCGCCCATAATCAGGCATGGAGCGGGATTCCGGCAGGTTAAGGTTGGTGATTGGCTTCAGGTTCTGGTTATAAGCTCATAAGCGTGTCGCTAGCCTGGCTGGCCATGGGAGTTCACATCCATGAGCGACAGGGCAAAGTCTGTCAGCGCGCCAAAGGTTGAACCGGCAGCCATGAGGCCACGGTCGGGAATGGTGATCTTGAATTCTCTCTCGATCGCCAATAGCAAGCCAATAACAACACAACGAGCTGCATGGAGTCGACGCCCAGTTCCCCACAAAAACTCGTTTCGCCCGTGATGCCAGACACCTTCAGTGCCGATTCCACGAGCGCGTGCAGACGCTCCTTGGCGTCGTCTTTACCTGCGTCACTAGCTTCTCTCACTATCATTGCCCTCTCAATCCGCCGAATCTCCCTCGCTGCCCGACGGGTGGTCCCGCCTCACCTGTGGCGCGACGTGATATGCCTCGCTACGCTTTGCGGATCTAGGCAGAGGGTGTCGTCGATGTTGGCAAATACGGATTTCAGACTATTTTTGAAGATCATGTGATTTTATGCGCCGTCGCAAGGAGACGCACCGAGGAGAGCACGAGGATGTCCGGCATGATACCGCGAGAGATGTTGTTCTGTGGCGCAAATTTCTTAAGGATCCTCAACCAGAGGGTCTGCGAGACCGGCGTCTCGGCACGGGTGCTGATGACGCAGTGGCCCGCGTGAAGATGACGGGATGGTGGCCAGACAGGAGAGGTTGATGGGCGATCGCGCACTACGACGGCTATGAGGGCAGTGTCTTTGCCCTCATAGGGGCGTGCGCTTGCCCTGCCTTGGGGACGCCGCCTCGCACTCATGTCGCCCAGCCGCGATTTTGTCAAATTCTGCTGCGAGTATATCTTCTGGTGCATCAAGAAGACGTTAACAAAGAAAGTTACAGAAGGTATCACGAAAAGAGCTGTAATATAACTGAATATTGACTAGCGTCTTGCGTTGTGGGACCGCCGTCGGGCGTTTGTGAGGATGGTGTTGATATGATTGCAGACATAACACATACATCTGAAAGCAAAGTATCGGGGGGGGGTAATGGACCTTCATATTGCCGTGTTTGATGCGGACGCGAACCAGTCACAGAACTTGGTGGGCCTGATAGGGAAGCTCGGCCTCACGTGGTACGGCTCCCCAGGCCATCTGGTGCCGACGGTCGTCGAGCGCAGCGCGTATCCTGATCAAGGCATTGACGACCTGGACGTCTTCGTGCTGAGTGGCGTGGACTCGCTTGTGAGCCATGTTCCGGATGTGCTCTTCATTGCCAGCAAGCTTGGCGGAGTGGACGATGCCATCCGAGTGGTGAGCGGCTTCCTCTCCGATAGGCATACGACCCAAATCATATTCATAGTACCCTCGGACGTGTCTGTGGCGCACGGCCACACGGTGCAGCATGTGGGGTTTTTGGTGTGTCCCATCTCCCTCGACAAGCTCGAGCTTGCCCTGAATAGGGCCGTTCTCACCCTGTTTCTCGAGCGATGTCAGCTAGGCTTCGATTGTCCCCTCTGCCTGCGTGGCACCAAGGCGACGTTCTATGTTCTCGTAAGTGACATTCGCTATGTCGAGAGTCGTGGGCGGACGCTGCACATTCATCTGAGGCCTCACTCAAAGGCCATGAAGAAGGACGACGTCTCCGACGGGATGGCCTCCGCCTCCGGCATCCTCGACGAGGTGATTCCTGTCACCATGTCGCTCAAAAAGTTCCAGACCTTCGTGCCAGACACGTTCATTCGCTGCCACAACAGCTTCCTCGTTAATCTGAGCTGTGTCTTCAGGCTCTCGCGTGACACCATCACGCTCAGGGATGGGACCTGCATTCCCGTGAGCGAGCGCAAGAGGCAACACGTGCAGCAGCAGCTCTGTCGTTACGGGAGGGTCGTTGCCTAGCACGTGCGCGGCCCTTGGGAATCGGTATGGGAAGGGGAGCCATGGGACTGTGGGGAGTCGTCATCATCCTCGTGTTCTTGTTCATGATCTATAAGATTATTTTAAGGGGATTCAAGACGGGAGGCAGCTCCGGTTCCCTCGTGCTGCGCCTCATCCTCGTGGTGTTCGTGCTCGTGCTGGTGCCCTACGTCATCCTGATGCTGGTGGACGCCATGTCCATCTCCATGGGTATCGACATAGTGCGGTTTGCGGACGTGGGGCTGGAGAAGTGGCCTGCCGGAAAACTCATCAAGGGGATGCTTGCCCGCGGCACTCCCGTCTCCCCGCTCGACGTGGTTGTGGGCACGCTCCAGGCGATCTGCGTGGCTTTCGTGCGGGCCCTTGCCCCGGAGGTTCCCATCAGGGACTCCCTCGAGGAGGAGCATGAATACGACCTTCGCAACGACAGGCCCCGCCGGAGCCTGAGGGGCTGGATCGGCTGGGTGCTGCTAGCGACACTCGCGAACTCGTTCGTCACGGTGCTCATCAGCACCATCATCGGCCTTATCTTCTCTTCTCCCAAGGAGGTGTTGCCCCTCTTTGGGGTGATTGGGGTCATCGTTGCGGTGATTCCCGCATTTGGTCTTGGCTTCGTCTTTGTCAAACGCATTTTGCACGCACGGGTACTCCAAGGCAGCGAGGGGCCCAGGTTCAAGTATCCCAACATCACGCTTGCCTTCAAGATGTTTATGGCCATCGGGCAGTACGCCTGCATCACGGCAGGCCTGATTGTGATCTCGCAGAACGCCTACCTCGGGGCGTGTGCGGCCCCGTTCTTTCTCGCGGGACATGAGGTGCTGGGCATGGTGAAGAATGCCGTGAAGCTCGACATCGAGTAGGCTGGGGACCTGCAGTCATCGCCGCGATCGTGTACGCAGCGCCGGCAGTCATGAGCGAAGCTCATTCAGATATACACCTCACAGCTGCTATGAGTTCCATTTAGCAACAAGACTCCTTAAACTAGGAAAGTCTTGTACTGGTACACAGGATTGCTGGAATGTATCTGGTAGGTTTGATGTTACGGGGGTGTGGCATGGGGGACAGGCGACGAGCCCGAGGCTTTGCCCGCGCACTTCGTGCGACGGCCCTGCTGCTCTGCGCGACGACGCTCTGTTTGCTGTCGCTCTTGCGCGCGAGCGTGGCCTACGCGGCAGGGTCGGATCTTAAAGGTGACCTTACGAATCGCTACAACGTGGTGATAGTGACCGACGAGAGCGGTTCCATGAGCCGGACCGATCCGGACAACCTGCGAGGCGCGGCGATCGCCCGCTTCGTGGCGCTGCTTGCCCAGGAGGGGAACCGGGTAGGTGCCGTCGCCTTTGGCGAGGGAATCCCCCTGCAGTCCGACCTCAGGGACCTGACGAGCGTCCAGTTGCGCCAGGAGTTCGTGCAGAGGATGGACACGGTCGCGCTCGAGAATTGGACGAACATAGGCGAGGGGCTTAGGGCTGCCGTCGGTATGCTCGACGGCCAGAGGGACGCTAGCATACCCTCGATCATCCTGCTCCTCTCTGACGGCAACACGGACATGCCCAGCGACGAGGCGCGCCAGGCCTCCCTCCAGACTAAGGCCCAGGCCATAGAGGCGGCGCGCGGCGCGGGCTACAAGATCTACACGGTCAGCCTCAACGCGAACGGTGAGGCCGACTCCAACGAGCTGAGGCAGGTCGCCTCGGCGACGGGTGGGGAGTTTCGCGAGGTCACCAGTGCCTCGGACCTCCAGGGTGTCTACGACCTGTACTACTCGCTCGTGTTCTCGGCCAAGGCCGACCAAGGCAGCGACGTCGTCATACCAGACTCCGGCATCGTCAGTGGCGCCTTCGACGTCGCGAGCATCGGCGTGGAGGAGGCAAACGTCCTCATAACGGGGACACCGACGGACTACTCGTTCACGAGGCCCGATGGCACGAGCGTCACGCGCGACCAGCTAGCTGGCTCGACGTTCTCGACGGAGGCGCTCACGGCGGTGAAGGTGAGAGAACCTTTGGCAGGTACCTGGCGCTACACCGTACGCGGGGTGCCCAAGGACCATGTTCGCGTCGATATCGTCCGCAACACCGATGTCTCCGTCCGGCTCGAGTCGAGCGCCAGCGGCAGCAAGCTCTCTGCTGGTGACAGCGTGGACTTCACGGCGACCATCCTCGAGTCCGGAAGACCCGTCAAGCCCGAGGTCTACGGGAGCTTCTCCGGTGAGCTTGTGATCGAGGGAGCAGGCGGCTCAAAGCAGGCACTGGCGCTCACGGCTGGCGAGGGCGGCTTTGCCCTGACGGTTCCCTTCCCAGATAGGGGCAGCTTTGCGGTGCATGCGACGGCCTCGGGCGAGGGCTATGAGCTTTCCACCCAGACGCTGAGCCTCAACGTGGGAAACAGCGCACCTGTGCCCGGCGAGACCATACAGGCGACCGTCAACCTCTGGCCCTTCATCGACAACACCGCGACCATAGACCTCACGCCTGGCGCGACCGACACGGAGGACGGCGAGCTCTCCTATGAGGTCGAGTCGAGCGCCTTCATGCCCGACGAGTACAAAATCGACGGCTCCAAGCTGGTCCTCAGCGGCTACAGCCTTCCCGAGGGGTCGTTCACAGTTCGCGCGACCGACTCGGACGGGGCGTCGTGCACGTTCGACGTGCACGTGAAGACCGTCAACATAGGCCTCATCACCTGTGTTGTCATCCTCGGGGCCATTCTGCTTGCCCTTGTGGTGGCGGGCGTCCTGCTGCGGATCCTCCTGAACAAGCGCTTCTACGGTACTTGCTACGTGCGCCCCATGGACAACGAGAGCTCCGAGTACCAGAAGGAGACGAGCCTGGAGGGGAGCCGCGGGCGCATCAAGCTCGCTTTGTTTGGGGTCGAGACCTATGGCATAGACCCGCAGGCGTACTTCCAGGCGTCGGGCAAGGACTACGTGACCTTTGTCTCTAAGGTACCGGTGTACAGCGGCGGGCACATGCAGAGGAAGGTGCGTGTAGGTGGCAACGGCTACGAAGTCCCGATCGCCGTGGACGAGAAGGGACAGAAGGGCGTGGTTGTTCGGTTTAAGAGTGAGCTGAGTCGTTCAAGGTGAGCTAGACGCTTCTAAGACGAGGGGAGAAGTATATGAGTGGGCAGGATTCTGGAAACAACGTCGGTAAAGTTGTTGATGGTAACAGCGATGAAGTTGTTGATGGGGGACAACGGTTCATCCAAGATGACTCTGCCGTTCTCGCCATCGGCCTTGGGGGTACGGGGGTGGACTGCCTGCGAACCCTTAAGAAGAGGGTTTATGAGCGCTTACAGTCGGACAATCCCGGCGAAGTGGTACCCAGCTACGAGCACATTAAGTTCCTGGCAGTGGACTCGGACGCTGATGGCATGGGGAAGGCGGCAGATTCGTCTGTGTATGCTCCCTACAAGCTTAATATGGACACGGAGTTCTTTGATGTCTCTTGCGCGGACAATCTCTCAGAGATATTTGGGAAAAATCGAGTCAATCTAGCGAAGGACCCCGCGTACCGTGAGTGGCTCCAGTTCGATGACATCAATAAGGTGGGCACGGCCACCGATGGTGCGGGTGGCGTCCGCCAGATAGGTCGCTACCTGCTGGTGAGAAGGGCCTCCGAGTTCGTGTCGACAGTTCGTGACATGGTCACCGAGGCGATGGAGGATGCGAACGGCAACAAACGCAAGGTGTACGTGCACGTCTTCTCCGGTCTAAGTGGCGGTACGGGCTCCGGGACCTTCCTCGACGCGTGCTACCTCGTCCGGGAGGCATTGAGAAGGGCGGGCGCTAATGGCAACAGTGTCATGGGCTACCTCTTCCTGCCCGACGTGAACCTCGCCGACAAAGCTATCCCCACTAACGTGAGGACGTACATAGAGCACAACGGCTACGCTGCGATGCAGGAGCTGGACTACTGCATGGGCTTCGGGAGAAACGGTGACGTCTGGCACCAGACCTACCCCCGCGTGGGAGATGTCCGCTGGGAGACGCCGCCCGTGGACCTCTGTCACCTCGTGGCCGGGAAGACGTCGAAGGGTGTGCCCCTTCCCAAGATGTACAAGCATGCGATGAGTGTCGTGGCGGACTACGTGATGGACTTCCTTGCCAAGCCTGCACAAGTTGCGTTCAGTCTTAAATCTCATCTCAGTAATGTGCAAACCATCAGGGATGCGGAGAGGAACGAGCAGGACGCCGGCGCCTGCTACGACTATCTCGTCCTCGGGGCCTCGTGCGCCGTCGTGCCGTACGGCAGGATCATGACCTACCTCGTCTCGGGCTTCTTCCAGAGGCTCGAGGGGCTCGGCATGCGCGGCAGGGTCCCGACGCAGCAGGAGGTGGAGCGGTTCCAGGAGGGCGTTGGCCTCACGCACGACGCCCTGCTGCGGGAGCTGCAGAGGGGCGTCGGGGTCGACCCCGACTACTACGGCGCGAGGCCGGCCGACGCGCAGAAGAAGAGCCCGAACGTGGAGGATCACTACATGAAGCTCGAGGCCGCCGCGAAAGGTGCCCTCGCCCAGAACCTCTCTGACCTCTCGAGGGATGTCCCGGGCCACGTCCGGAGCGGGCTGCCCACCGACGGCAGGGCCCAGGCCGTGATGGCCAAGGTGGTGAACGCCGTCCTCGACGCCATGGTTGACCCCGAGCGCGGCCCCTGGTACGCCTCCGCGCTCTTGAGATCCGCCAAGGTCACCGACCTGCTCGCGGCGGCCCGGGGCATCGAGGCTAAAGCGGAGAGGGAGCGTGTGCAGGAGGAGGCCCAGGATGAGGAGGGAATGCCCATCTTGGACGACTTCGTCAGGGCGCGAGATGAGTTCTTTAACTGCTCGTTCCGACTGAAGAAGAGGTACGACGCCTTCGTCGAAAAGACCTGCGAGCTGACCCGCTGCCGCATCAGGAGGGACTCGTACGAGGCGCTCGAGAACCTCGCAGGTAGCTTGGCCGCGCAGATCAAGCGCCTCGCGGACGAGCTCACCGGCCCCTTCGAGGATGCCATGGGGGAGCTCATCGATATCTTCGACGAGAGCTGGTCTTACCTCAAACACTTTGCGGACGGCGCGAGCACCTACGAGCAGCCCGTCGTCACGATGAGTCAGATCGCCCCCGTGCTCGACGGGGAGCTAGAGAGTTGCGACGTTGGCAAGGTTACCCAAGAACTGCTCGACACATTGCTGGACAAGAGGGGCAGGGCTGCTTTGGGGCCGGGCGGCGACAGATCCATCCTGATATACCGGGTCTCAGACTACTTCGCGGAGACGTTCAAGGACTGGTCCCAGAGGTCGCTGACAAAGTACCTTGAGGACAAATACGGCATACACAACAACCCGAAGCTGCTCGCCAAGCAGGTGCAGGACGACCTCCTGAAGAATATGGACAAGCGAGCCGAGGTACTCTTCGACACCGACGGGAGGTACGACCTGCCGGACGATGGCTCCGCCCTCTGCTACGTCACGGTGCCGCAGACCTCCCCCGTGGTCGTGAATGCGGCCGATGGCTTTGTGAAGGCAAGGGGCACCGGATTCAAGAAGCGCGAGACCTCCGCGGCCGACCGCGTGAGCTTCCTTCGGCTCAAGATCGGCGTCCCCCTGTGGGGCTATGGTGCCCTCGCGCGCTGCGAGGCCGGCTACCAGCCCGCGCCCGGCAGGCACCTCTACGAGAGGGCGGTGTACGTGGATGGCGTCTCGGACTCCGCAGAGGTCGAGGCGTCCCGCGACTGGGGGAATCTGCCCTCGCCCGTTCCGCTGAGTCTCTCGAATTCTGACATATGGGTGGAAAAGCTTAACGAGGCGCTCGCCGCTGACGTGATTGTCCCTCACAAAAAGGGCTACTACATCCGAACTTTGACCGATGAGTTCATGGGGGGCATCCGCACAAAGCATGATGCGGCGAAGGGACTGCCAATCGTCGACAGGCTCAAGGTGCAGAACGAGCTACAGGCCATGGACTCCAATCGTGTGTACGATCCCAATGTGCATCTCCTTTCCGACATGATGAGACCCCAGAACATCAAGGCCGAGAGGACGATCTGCGCCGACCTCCTGGCCAAGGCCCCGGTGCTCGTCGAGATCGTGCGGGAGGAGCTCGAGAAGTGTCGCGAGATAGCGGGCTACATCGAGGATCTCCAGCCAAAGGTGGACCATGACCTCGAGAGCTTCCGCAATGCCCTGTTCACCGGGGTCATCGAGTTCTCCAATCCCGTCGTCCAGTACGTGAGCGGTGGGCTCAATGGACCGATTGTCCTTTCAGATAGGACATTCGGCCATGGAACCATCCCGCTCTACCAGGCATTACTGAGCTTCAAGGACAAGTCGGTGCTTGTGCCAGCCATGCGCAAAGCGATCGAGGCGCAGACGCAGAGCATCCTGACAGCCAACCAGATCCCTGCCAGTGTCCAGGGGGCCTGCGACGCCGTGCAGAGGGAGCTCGATCGCGGTCCTAATCTCATCGCAATTGCGACGGCAATGTTCCCTCGTGAGGTTGGTGAGGTGACGAATTTGCTCACTGATCTCACAAAACAGTTAACTACCTTTAGGTTGGCGTATCTGATTCCCGGTGCAAAACCAAATACAAACTAATCTTACCCTCCGGTGTCTGATCATGGATTGGCAGGTGCCGGAGGGTCTTTGAAGGGCTCGAAGAGTTGCCATGAAGAAGGATGATATCTCAAAACTGATAAGTGATGCCGCCGCCACCTTGCACTCAAAAGGCAATGATGGGATGAAGAAGTACGTGGGAGTGGAGTATCCTGCGTGCGTCCTCTATTACGGAGAAAGTACGTCCTCATTTCACAACGGCATACTCGAGGCTTTACAAAGCGAATGGGGAATTGTTGCGAGCATCATTCCCTTCTACACCATCTTAAACCCAGACTTGTCAGGTAGGCATGCACTGAAGGACATGCAAACGAGCAGTGATGCGGATGTGAAGGCATTCCAACGAACTGTCATGAACGTACAGGGTGCTAAAAACAGCAATTTCTTCAATGACTCGACTGTACTCTATACCTTTTGTGTTGTCGATACACGAGGCATGGGGCCTGAGGACTTTCATGATTGGTATGCATGCATAGAGAGCATACAGGATCTTCTCGATGGCGTGACACTCAAGACCCTGCTCATTGTGTTATTGAACAATTCTGTGGGAGATGCCAATGCCTCATCGATTACCCAGAAGCTGGCCGAAATCTACGAGGGTGAAGAGCTTGGGCCAGCGAATGGGCACCTTTACGAGGGTGTTCTCCTGTATGGCAACCAGAGCTGGAACAAGCAGTTTAACGGGCTATTCGATGAGCAGGTCGCTTGGGAGCATGGCGATTGGAATGTGTTGGCTGACGTGATAATGCTGACAAATTCCCAGTATGACGCTACCACACCAAATTTCAACGCTGTGTCAAGTCTGAGGCGTCTGCTGTTCTCCACCCGGGTCCATCCGGCGGTGACTGTAGCGCTCAAACAGGTAGAGAAACCCTGTGGTGACATCGCAACTGTTTCCTTGTTGCATGTGGTGAGGCAGCTTGATGCGAGCTTTACCGCAATGAAAGGCGTGCCTCTTAATGAGCTAAGTGTTTTACAGGCACTTGGGTGCAATGAGAATGGATATTTTCAATTTACTGATTATCTTAATGAGCAAATTGATGAAATTGAGAAGAATACATTTAGAGGCTTTGAGGATGGCCTACCCCTATCAATTGAATCTGCACCGCTCACGAATACGCCTGATATGGGCAAGTTATCCTATGGGGAGGCAGATGACAAGACAAGCGGATGTCTCTCTGCTTTTGTTGAGAACAACCATCTTCGCCAGATCGATAGGGTGCTGTCGGATGGCTCCAACGGTATCGATAAGCTGATGCGGGAACGTGTGACGTCGACCCTCACCGCACCCCAGCTGCTCAGTCTCAGCAAATCGGCATGGGAACAGTATATAGAGAAGGCCTTTGTTGGGGCGCGGGCATATGATCCCAAGCGGCTTAAAGTCCACGATGCCATAGATCGTAAGTTGCGCCAAAGGGTAGCGGAGAGGGCGCACAGATGCGTCTTGGAAATCATTAGCGAGCTCTATGATAAGGCTGGGCAGGTTGAGCGTGAATTCAATGCGCTGAAGAGTGATGTGTCGCTTGCCACGAGTAAGGTGGATCCCAATCTTGATAACTTCTATGGGAAGATAGTAAATTCCTTCTGCATATCTGGAGGGCTGCAAGAAGTGCAGCAACTTGTTTTTACCTCTGATGGTGATCGGAAGACGATGATCGAGGCTATTCGTACAAAAGGACTGAAAAATCTCTTTTCCTATGCGATCGATAGACAGAACATATTCAGTCTCGGGTTTATGGATGAACTTACGCTGCGTATGGCAGACGGTAAGGCCCAGGCTGCTGCGCAAACTGTCATCGGGGCTGATCTTGTTAAGAACATCTCTGGTCAAGTCGCCTACCGCTCAATATTTCCACTTTCTAGCCAGCAGGTCGAAGCCTATCTCCTGCACGTTGACACTAACGCGGTGGGCATTGATCGGGCCAGCTCATCTGGCAAGCTTTACTCGTATTTGAATAAGCGCGCCATCCCCAACGGCACAAGTCGCGTTTTCTTGAACATCGGTCGGCGGGACAGCGCTAGCTCGCTGTGGTTCTACGCGCTGGATACCCAGCATCTTCGAGGGTAGGGAGCGCCATGAAGGTTAGGATCTTACCGAGCTCAAACCAGCATTACGTGGGCAATATGCAGCAATCCTCAGGCTCTCTTACATGGGACTCCGCTGGCATTGACTGGACTTTGATGGTGCGCGGTGCCTATGGTGAACCCATAAACATCGATGACGCTATCGTGAGGCAGTTGCAAATCCGGGGTGCCAGTCTTGTAAATGGTCCTGATGGACCCGTCAAATTGTCTGACGGGCGCAGCATCGTCCTGCTACGCTTCAACCCTATGATGGGCGGTATTAATGCCTACAGCTATTCAAATTCCCATGCGCACTATGCCATCTTTGGCTGTGTCTATGAGAGTGAAAGTGACATGCTGACTGTCTACGAGCCCGATTCTTTTGCAGTCACTCAGTGTGACGTGCCCGGTACGGTGAAAGTGTGTATCAAGAAGCAATGGGAAAGACAGCGGCATTGGCTCCCCTTTTGCAGCAAAGACGTCTTCCTTGGTTATAGCGTAAGCATCGAGTATGACGGCAAGCTATCTGATGGTGAGGATTGGGGTCTGCAGTACGAGTTTTCTCCCATTGGCTCGTCTGGTAAGTCATTTTGCTACCCCATCGTGTCAAAAATGGTAGGGGCGAAGCTCTTGGTCCGTGCCTCGCCAGGGCAGGAGCCTCCCAAGATAAAGAGCAGCAAGAAAGGCTATGTGGTCGAAGTAACTGCTGACTTATAGGCATAGGCTGCCAGTCGGCGTAAGTGGGTCGAAGGGGATCGCTATGGGAGACAAGGATGCAGGCAAAAATATTACCTGCCCATTTTGCTTCAAGACGTTCAAGGATTGGCAAGTCCACTTTCGTATGGAGGTACGAGAGGATAACCCGCTCTTTGAGCCTCAGAAGGACCAGAAATATGAGGACTTTTGGAGCGAGTATGGAGGAACAACCGAGTATGGGGAGTCTGATGAGGTGCCTCCGTACTTTCACCGTGTGTATGATCCTTGTGACCCCGGCCATAAGAATGCGTTCATCAAGGAGGATCCTCAGGCTGATCCCCCGCGCACCGTACTTGTACGTGATGTGGACGGCATGGTGATTGGGGCGCGAGATAGCTTTGGTAAAGTGACCAGGGAGCGGGTCTGTCCTCACTGTCATAACTTACTACCGGGGGCTTACGGGCGCAAACCCGTCAAATTCATATCGTTCATTGGCATAACGGGCGCAGGGAAGACAGTGTACCTTTCGCAACTATGCAGGTTCATGCCAGCTCAGTTAGGAGCCTACGGCGTCTCGGTGATGCCAACAAGTCAATACGCAAATGATTATATGAATAAAAACAAGGTCGTGATGGGGGAAAAGTTACCGGATAGTACTAACCCCAAGCGACTGCTGCAACCACTTTGCTTTGACTTCACGTTTTCGGATCCAGATGGAAAGCAGCACACGCAGACGTTTGTGTTTTACGATATTGGGGGCGAGAACCTAGAGGAGAAAGAGGGAGAAAAGCTTGCGGCCCAAGCACAGAAGTTTGGTAGATTTATTCTACATTCTGATGCGCTTATCCTCCTAATTAATCCGGTGCAGTTTACTGGTATGAATAGGGATGCTATCGCCAAGGACGATGAAGAATCCAAGGGCAATGATGAACCCTTGAACCCTGCCACAGCGCTAACGGTTATTTACAATCTTTTTAATCAAGGCCTGAATCCTGATGCTCTCAAGAATATACCCCTAGCTGTCTGCATCTCGCAGGCTGATAAACCGCTAAATGGCATGGATTCGGCTTGTCAGTATATCGCCGAGGGTGAGAGCCTATCGGGCATGCGAGGTGCTCCAATACCAGGCTCCGGTGCCTTGGTGTTTAACGCGGCTGACTACAACCACTGGCAAACGTACATTGATAGCTTCGTAAACTTGCTCAAATCTGGAGCAAACGAACTGGGGACAAAACTTAACAATGGCTACGAATGCTATAACTACTTCATGATCGAGTCAATTGGCGTGCCACTCGAGAAAAAGTCTGAGTCGAGTGGCACTGTCTATCAGGTACCAAGCAAGCAGCCAGTGCCCAAGCGCATCATAGAACCCATCCTCTGGATATTAACGATACTCTCGATTGACGGCAGCGGAAGGCCAGCTGTGGCCGTTGAGGGAAAAATCAATGAGCCCAAGGGATGGAGATGCCCGTCCTGCAATAAGTGGTGTAGCGACACCGTGACCTTCTGCCCCAAGTGTGGGGTGAACAAAAAAGGCGAATGGCGCTGTCGCAAGTGCAAAAGGCTCAACCCTCGCTCTGCAGAGTGGTGCGAGAGTCTGTGCTGTAACACGAATCGCTCCGGTGGATCCAGAGGCTTTTTCGCGGGACTTTTCAGTCGTATCTCGCGTGGGCGTGGGGCGTAGCCGACGGCATGGTGAGCGGAGGTGTCTGACAGGTGGACTACCAACAACTTTGTTACGCGCGGGTAGGTTGTCAAGGCGTAGGCTCTGGTTGGCAGGTGCTGAACGTCTCGCCGGGCGTCTCGGCGCTCGCGAGGTCGGTGTATCCGCGCCTGCAATCGGGAAACGCCAATACCTCGGCAGACGTCCCTTCCGAGGAGGGGCAGCTGCCTCAGGTGCTCGAGCTTCGCTCGGAGGGCGAGCTCGTGTTTCTTACGATGGTCACCTATGGGGTGGCTGATGAGCTGGGGCGCCCCTCGTCCTTTTCCCACGGCCTCGTGTTTGGGCGCGACGAGTTCGAGCGGGACCCGCAGCTGGCCCTTCGTGTGAGGCGCACGAGCTTTGGGCACACCCTGGAAGATACCCTGCCCGAGAGGCTGCGGGTGTCCCTTGCCGAGCCGATGGGCCTCGCTTTGGCGCGAGAGACGTGCGGTCTGGACCTTACGGGCCATGGGAGTCTCCTTTTGTGCGTGTGTGAGGCGCTCGGCCTTGACGGAAGGTTGGGCAGGCCGTTTCGGATCCTGTGCGACTGTGAGCCTCGGACGATCCACGCAGTCCTTACCTGCATCTACCAGTCCATTCCCTATGGGTTGCGCGGGCGGGTCTCGTTCAGCACGTTTCAGACCAATGGAGGGCTGCCCGTTGACGTCGTGTTTTCCAAGGACGACCAGGGTCGCGGCTTCGACCTGGCCAGAGGCGCGATGCGAGGGGGCAAACCGCGCGAGACCAGCGTCGCAGGTCCCGAAAGACGGCTTCCCGCGTTTGCCGCGCACGTCCTGAGGACGGAGGTCAGCGAGGGGGAGCTCTCTCGATACCTCGGGGCGCTCGAGGACGAGGTCCAGACCTTCTGCGATCCCAACGAGGCCTCCGTTTTCGCGTACGAGGCGGCGTACGATAGGCTTGTGAAGAGTGGCGTCATCGAGCGCCTTGAGTCCTATGAGCGCCCACTCGATCCAGAGTCGATCGTGAGGCGGCTCCTATGCTCCATGGGCCTGCCGAAGTCCGAGGACGCATCGCGCCGTGCCGAGCGGGACGGGCTTGTGTCCGGTGCCCTGCGAGACGTCGTCGAGCATAGCGTGGCCTTGGATGACTGGGTGTATGATGAGGTGGCGAGGGAGGCTGAGGACTCCAAGCTCGACTCGCTCGAGGATGCGCGCTTTGACTATGACACCTCTGTGAGGTTCGCAGGCAAGACCCCAGAGGAGGGTGCCGCCTATCTGGCACAGGAGTACCCGGACGCTGCGTCTCGCTCGACGGCCGAGTTCCTGAGGCTGCGCTTTGCCCTAGCAGGCAGGCCCGCGTCGAAAGACGTCTTGATACGCTATTATGAGAGGCTTGCTGATAAGCTGCAGGGGCCGGGCGGACCTTCGCTAGATGACATCAGGTCGTTTCATGACGAGACGGCCATACTCGAGGACTCGTGCATCGACGAGCGCGTCGCCGCGCTCTGCGAGGCGCATGCGGTGGCCCGGGTGGTGCCAGACGGCGACCCGGTCGAGCTGGACAAGGCCATAAAGGCGCTCTTCTCCCAGGTCGAGCTATCTGAGGACGCAAAGGCCCGCATACGAGGCGCGGTTGCCGTGGCATACTGGCGCAGCTTCAGCTTCAAGGCCTTCAACTTCAGGTGGAAGACGTACAAGAACAGCGTAGTGAACCAAGAGGATGTCTGCAAAGGACAGCAGGAGTACCTTGCAGCACTGCTTGCGTCTCGAGTTGGTCAATACATTATTAGAACCCAGTACGAGCTTCTCGCGAGATCATACCGGGTGCTTGAGAGGGCGCTCGAGAGGCTGGAGGGCGAGAAGAGCGAGGCCCTTAGGGAGCGCCTTGCCGCGTACCTGAGGAAGTGGGCACGCGCGGGAGCGCATCCGCAAGACTTTGACACCTTGTGCCGGGTAGCCCAGGCCATCTGTAACCCTAGTGAAGGCGCGAAGGCGCCGCAGGTGTCCTCGACATCTCCCCGAGGATCTGACGTCCAGGCCGTCTGTGACCCCGGCGACAATGCGAAGGCGTATGCGTACATGCTCGAGAGCGGCATGCTTCCAGACGACCCCGCTGCACTTAGGGCCATGCTGGACCACTCGAGGGTACTGCGGGAGGACGGGGAGCGTAAATGCTTGCTGGAGCAATGCAAGCGCATGTCCAGGCAGCGACGATCGCCCGTCTCCAAGCATGCGAAAGACGTCGCCCGCGCGCTGCGCTCCCACGAGAGGGAGTCTCGAAGGTCTCGGAAACCAAGGCATGCGGAACCCGTCTTGAGGCACGGGGCGCGGCGTGAGGGGCGCGATGTCCCGGCCAACGCGGGACCTGGCACTCTTGCGCGCTTGTTTGGGTTCGGGGGAAGAGGAGATCGCGAGCCTCATCGCGAAGATATCGGGACACGGGGCTTCGAGCCCCCAGAGGGTGAGGACCTGACCGCACGCAGGCTCAACGGGCTCATAAAGCCAACAGAGGTGCAGGGGGCAACGGGAGGGTCGTCTGACCGTGTCGGCTCTTCCGGGAGCCATTCGATCAAAGGTTCGAGGAAGCAGGGTAGCCGAGATGGGAAACGATGAGATGACCGCTGGCCTCGATACCGGCAAAGACAGCCTTATCAGCGTGATGTATGCGCCACACCTTGCCTACGTCACACGTGGCAAGACGGTCGCCTCTCCTGGCGGCGAGCGTCGGCTCGTGGATGCCGTGCCGCGAGCCGGTCATCCCGCGCAGATCGGGGCGCCCCTTGCCAAAGAACGTCTCTTCCTCGTCCCGATAGACTCCCTGTTTCACATCCCGCGTGTCTCACCAGGGGAGGGCATGACACCCATGCGCAGGGAGCGACGCGAGATCCTGCAGCACTGGAACAGCATCATCATCTACCCCAAGGAGCGCTCGGACTGGTGGCTGCGCGGCGTGCCGGAGCACCCGCTGCGGTCCCACTTCGACTGGCCCGTCGACGTGGCAATGACGACCGACAGGGAGCGGAGCTTCCTCGTCTTTCCACTCGCGTCTGACGCCGGACGACTCCGCCCGCTCTCGGAGCTGATGGTGAACCTGGACGATGGTCGCCCGCCCCTCGAGTTCGGCCAGGAGATCGCCGACCATCGCGACCTGCGCATCGCGCTGGCACGATCGCTGGTGGAGGCTTGGGGGCAGCTTCGTTCCTGTGGCTATTGCTACGGCTGCTATGACAGCTCGAACATCTTCTACGACCCCAAGGCGAAGGAGGTGAGGTTCGGCTTCAGCATGGCGACGCGTTACCTGCCTGACGGCGATGCCGAGTCCCCCTCGCCGATTGCCGTAAGCAAGGGCGCGAGGGAGAGCCTCATGTTCGACTACATCGATCCCGTCTCCTACGGACCGATACGGGAGGCCGTAGACCATGGGGAGCAGCCCAGTGCGATCCTCTCGCGGACGGATGACTTCGTCATGTGGGCCATGGCGTTTCGCCTGCTGGTGGGCAGGCTACCCTTCTATGGTCCCAGCGCGCTGACCGTGCCAAACACGAGCGGGGAGGATCATCTCAGGTGGATAGACCAATACCAGAAGAACGCGGTTTTCATCTTCGACTCGACCGATGACTCAAACCAGGTTGGTGGGAGGGACGGCTTCGCGGGTGAGGAGGTATTCAGGGAGAACTGGGAGGCGATACCTGATGACCTGCGCGACGAGATGTTCGATCGCTTTGATAGCGGTGGCACGGCGGCGGCAAGCTGAGGAGTCGCGATTTGTCGCCGCACGTCCTTGGAGCCTGCCCTGTTGGCGAGGCTGCCTCGGTGGACATGAGCAGGAGAGACGGAAAGTTGGGAGGTTAAGGCATGGGTTTATCTGATCTTTTTAAGAGGCAGCATCTGATACTCGTCATGTCCTTTGACTGCGATGACAGCGGCCATATTTCGATGAGCCCCATTTCTCATATCGAGAACTGCCCGAGTCTCATCAAACCCGATGGACAGGTAGACACTGTCAATGCGTTCGGAATAATGAAGGTGACATTGTTCACTGTTGAGAGAGCAAGAGCTTGTAAGGAATTTGCGCTCTGGATTGGGGAGATGCCCAAGAAAGGCTCTTCTCCGATCTTCTATGACTGCATCAAGGTAAAGGACTTGGATTTCTCAGTGCCCGGAAAGATAAGGGGTCAGTTTGCTCACATAGATTTTAGGAATGTCAATGACTCATCCGGACATCACAGCGGCATGGTTTTCAAGGTTCCGGTTCCTGATCGCAGTTTCAGTGTAAAGCTCAATTACGATTGGTAATCCTAGGGAGGTTGGCCATGCCCAAGAACTCATTTCATTCCTTTTGGGGCGGGATCACAGACGAGGTGTGGCAGTGCGCTCAGGACGATTTTGCCGCCCTCGCCATCGGCCTCGGGGGCACGGGCATCGACTGCCTGCGAACCCTTAAGAAGAGGGTTTATGAGCGCCTGCGGCCGGACAACCCCGGTGACGCGGTGCCCCGCTACGACCACATCAAGTTCCTGGCAGTGGACTCGGACGCCGTGGGCATGAAGAAGGTGGCAGATTCGTCCGGGCATGCTCCCTACAAGCTTGATATGGGCACGGAGTTCTTTGATGTCTCGTGCGCGAACAATCTCTCGGGGGTATTTGGGAGAAATCGAGTCAATCTAGCGAGGGACCCCGCGTACCGCGAGTGGCTCCAGTTCGATGACCTCAATATGGTGGGCACGGCCACCGATGGGGCGGGTGGCGTCCGCCAGGTGGGCCGCTTCCTGCTGGTGAGGAGGGCCTCCGAGTTCGTGTCGACAGTTCATGACATGGTCACCGAGGCGATGGAGGATGCGAACGACAACAAACGCAAGGTGTACGTACACATCTTCTCCGGCCTGGGTGGCGGCACGGGCTCCGGGGCCTTCCTCGACGCGTGCTACCTCGTCCGGGAGGCGCTGAGAAGGGCGGGCGTCCAAGACTGCATGCTCATGGGCTACCTCTTCCTGCCCGACGTGAACCTCGCCAACACAGCCATCCCCCCCAATGTGAGGAAGTACATAGGGCACAACGGCTACGCGGCGATGCAGGAGCTGGACTACTGCATGGGCTTCGGGAGAAACGGCGACGCCTGGCGCCAGGCCTACCCCGGCCTGGGAGAGGTCCGCTGTGAGGCGCAGCCCGTAGATTTCTGTCACCTCGTGGGCGGGAAGACGTCGCAGGGCGTGCCCCTCCCCGACGCGTACGGCCACGCGATAAGCGTCGTGGCGGACTGCGTGACTGACACGCTCGTCAGGCCTGCGAGTCCTTCGTACAGCCTTGAGTCTCTCCTCAGTAATGTGGAGACCATCAGGAGCTCTATGAGGGGTATGCAGGACGCCGGCGCCTGCTACGACTACCTCGTCTTGGGGGCCTCGTGCGCCGTCGTGCCGTACGGCAGGATCATGACCTACCTCGCCTCGGGCCTCTTCCAGAGGCCCGAGGGGCTCGGCATGCGCGGCAGGGTCCCGACGGAGGAGGAGGTGGAGCGGTTCCAAGAGGACGTGGGCCTCACGCATGACGCCCTGCTGCGGGAGCTGCGGAGGGGCGTTGGGGTCGACCCCGGCCACTACAACGCGATGCCGGCCGGTGCGCAAAAGAAAAGCCCGAACGTGGAGGATCACTACATGAAGCTCGAGGCCGCTGCGAGGGGCGCCCTCGGCCGGAACCTCGCGGACCTCTCGAGGGGCGTCCCGGGCCACGTCCGGACCAAGCTGCCCACCGACGGCAGGGCCCAGGCCGTGATGGCCAAGGTGGTGAACGCCGTCCTCGACGCCATGGTTGACCCCGAGCGCGGCCCCTGGTACGCCTCAGCGCTCGTGCGCTCCGCCAAGGGCACCGACCTGCTCGCGGCGGCCTGGGGCATTCGGGCCGAGGCGGAGCGGAGGCGCGACCACGAGGCGGCCCAGGATGAGGAGGGAATGCCCATCTGGGACGACTTCGCCAGGGCGCGAGATGAGTTCTTTAGCTGCTCGTTCCCACCCTTTCTGAAGGGGAAGTACGACGCCTTCGTCGAGGCGATCCGCGTGCTGACCTTCTGCCACATCAGGAGGGACTCGTACGAGGCGCTCGCGAAGCTCGCAGGGATGCTGGGGAGGCAGCTCACCGACCTCGCGGACGAGCTCACCGACCCCTTCGAGAGGGTCATGGAGGGGCTTATCGACACCTTCGGCGCGAACTGGTCCTACCTCAAAGCCTTTGTGGACGGCGCGAGCACCTACGAGCAGCCGATAGTCACGATGGGTCAGATCGCCCCCGTGCTCGACGGGGAAATCAAGAAATGTGACGTCGGCAAGGTCACCCAAGGGCTGCTCGACGCCCTGCTGGGCGAGGGGGGCAGGGCCGCCTGGGGGCCCGGGGGCGACGACGCGCCCTTGGCGCGCCTGGTCTCGCGCTACTTTGCGGGGACGTTCAGGGGACCTCTGAGGTCGCTGGAGGGCTACCTGGAGGACAGGTACGGCATACGCAATGACCCGAAGCTGCTCGCCAAGCGGGTGCAGGACGACCTCCTGAAGAAGATGGACAGGCGGGCCGAGGTGCTCTTCGACACCGGCTGGAGGTACGACCTGCCGGACGACGGCCCCGCCCTCTGCTGCGTCACGGTGCCGCAGGGCTCCCCCGTGGTCGCGAACGCGGCTGCGGGGTATGTGGCTGCCCAGGGCGCCGGCTACAGCGTGCGCATGACCTCCGCGACCGACCGCGTGAGCTTCCTCAGGCTCAAGTTCGGCGTCTCCCTGTGGGGCTACGCCGGCCTCGCGCGCTGCGAGGCCGGCTACGAGCCCGCGCCCGGCAGGCACCTCTACGAGAGGGCCGTGTGCGTGGAGGGCGTCTCGGATCCCGCCGAGGTCGAGGCGTCCCGCGACTGGAGAGAGCTGCCCTCGCCCACGCCCAGGAGCAAGATGGGCCAGGGCACCGACCCCGAGGTGCGCCGCCGCGCCGACGAGGCGGCGGGCGTCCTCGACGAGGCCCTGCGTGAGGGCATCGTCGTCAGGGGGATAGGCGAGTACACAATACGCACCATCTCGGACGGCTTCATGCGGGGCGTCCGAGATAAGTACGATGCGGCGGCGAAGGGGCTGCCGGCCGACGACAGGCTCAAGGTGCAGGACGAGCTGCGGGCCATGGATGCCAACCGTGCGTATGACCCCAAGAAGCACGTCCTCTCCGACATGATGAGACCCCAGAACCCCAAGGCCGAGAGGACGATCTGCGCCGACTTCCTGGCCAAGGCTCCGGTGCTCGTCGAGATCGTGCGGAGGGAGCTCGAGAAGTGTCGCGAGATAGCGAACTGCATAGAGGACCTTGGTTGAGGAGCGGGATCTCCGATCGGATACCGCCTGCCGCAGCTTCGACACCTCAGCCCACGTTGTCCCCCACGCCGGTGGGGGAGGATCTAGGAGTTGGCCATGTATGAGAACCTCTTGCTCTCCGCTGGGGGTGGTATCGTAGACGAGGCGTTGCAATGCGCTCAGGACGACTCCGCCGTCCTTGCCATCGGCCTCGGGGGCACGGGCATCGACTGCCTGCGGACACTCAAGGCAAAGGTCCACGAGCGCCTGCGGCCGGACAACCCCGGTGACGCGGTGCCCCGCTACGACCACATCAAGTTCCTGGCAGTGGACTCGGACGCCAAGGGTATGAAAAAGGCGCAACGGGATGGCTTTGGGGAGCTCGACCTAGACACGGAGTTCCTCGACATCTCGTATCCGAACAGCCTCTCCACCCTGTTTGCGACGAGCCGCGATGGCCTCGCGGCGGACCCCGCGTACCGCGAGTGGCTCCAGTTCGATGACCTCAATAAGGTGGGCACGGCCACCGATGGGGCGGGTGGCGTCCGCCAGGTGGGCCGCTTCCTGCTGGTGAGGAGGGCCTCCGAGTTCGTGTCGACAGTTCATGACATGGTCACCGAGGCGATGGAGGATGCGAACGACAACAAACGCAAGGTGTACGTACACATCTTCTCCGGCCTGGGTGGCGGCACGGGCTCCGGGGCCTTCCTCGACGCGTGCTACCTCGTCCGGGAGGCGCTGAGAAGGGCGGGCGCAGCCGGCAACATGCTCATGGGCTACCTCTTCCTGCCCGACGTGAACTTTGCAAGAGATTACATCCCCAACGTCGTCAGGCGATGCATTGGGAGCAATGGCTACGCGGCGATGCAGGAGCTGGACTACTGCATGGGCTTCGGGAGAAACGGCGACGCCTGGCGCCAGGCCTACCCCGGCCTGGGAGAGGTCCGCTGTGAGGCGCAGCCCGTGGACCTCTGTCACCTCGTGGCCGGGAAGACGTCGAAGGGTGTGTCCCTCCCCGACGCGTACGACCACGCGATGAGCGTCGTGGCGGACTACGTGACGGACATTCTTGCTAAACCCGAAGGCATATGTGGCAGCCTCACGATCCTCCTGAGTAAGATAAGGATTTTCAGCGCGATGGAGAGAGACCGTCAGGACGCCGGCGCCTGCTACGACTACCTCGTCCTCGGGGCCTCGTGCGCCGTCGTGCCGTACGGCAGGATCATGACCTACCTCGCCTCGGGCCTCTTCCAGAGGCTCGAGGGGCTCGGCATGCGCGGCAGGGTCCCGACGCAGCAGGAGGTGGGGCAGTTCCAGGAGGACGTGGGCCTCACGCACGACGCCTTGCTGGAGGAGCTGCAGAGGGGCGTCGAGGTCGACCCCGGCCACTACGACGCGAGGCCGGCCGACGCGCAGAAGAAGAGCTCGAACGTGGAGGATCACTACATGGGCCTCGAGGCCGCCGCGAAAGGTGCCCTCGACCGGAACCTCGCGGACCTCTCGAGGGAGGTCCCGGGCCACGTCCGGACCGGGCTGCCCCCCGACGGCAGGGCCCAGGCCGTGATGGCCAAGGTGGTGAACGCCGTCCTCGACGCCATGGTCGACCCCGAGCGCGGCCCCTGGTACGCCTCCGCGCTCGTGCGCTCCGTCAAGGGCACCGACCTGCTCGCGGCGGCGTGGGGCATCGAGGCCGAGGCGGTGAGGGAGTGCAATCACGAGGCGGCCCAGGAGCAGAAGGGAATGCCCATCTGGGACGACTTCGCGAGGGCGCGAGGGAAGTTCTTCGTGGCCCCGAACATCCCGTTTCTCCTGAAGGGGAAGTACGACGCCTTCGTCGAGGCGACCCGCGAGCTGACCCTCTGCCGCATCAGGAGGGACTCGTACGAGGCGCTCGAGAACCTCGCGGGTAGCTTGGCCGCGCAGATCAAGCGCCTCGCGGACGAGCTCACCGACCCCTTCGAGAGGGTCATGGAGGGGCTTATCGACACCTTCGACGCGAACCGGTCCTACCTCAAAGCCTTTGCGGACGGCGCGGGCGCCTACGAGCAGCCGATAGTCACGATGAGTCAGATCGCCCCCGCGCTCGACGGGGAGCTAGAGAAATGCGACGTTGGCAAGGTCACCCAAGAACTGCTCGACACATTGCTGGACGAGGGGGGCAGGGCCGCCTGGGGGCCCGGGGGCGACGACGCGCCCCTGGCGCGCCTGGTGTCGCGCTACTTCGTGGGGACGTTCAGTGACTGGTCCCAGAGGTCGCTGAAAGAGTACCTGGCGGACAGGTACAATATTCACGGCAACGATCAGAAACTCGCCAACAAGGTCCAGGGCGACCTCCTCCAGACTATGGGCAGCAGGGCCGATGTGCTCTTCGACACGGCGGTGGGGTACAAACTGCCCGTGAGTTCCACCCTCTGCTACGTCACGGTGCCGCAGGGCTTCCCCGTGGTCGCGAACGCGGCTGCGGGGTATGTGGCTGCCCAGGGCGCCGGCTACAGCGTGCGCATGACCTCCGCGACCGACCGCGTGAGCTTCCTCAGACTCAAGTTCGGCGTCCCCCTGTGGGGCTACGCCGGCCTCGCGCGCTGCGAGGCAGCCTATACGCCCGCGCCCGGCAGGCACCTCTACGAGAGGGCCGTGCACGTGGAGGGCGTCTCGGACCCCGCAGAGGTCGAGGCTTCCCGCGACTGGGGGAATCTGCCCTCGCCCACGCCCAGGAGCAAGATGGGCCAGGGTACCGACCCCGAGGTGCGCCGCCGCGCCGACGAGGCGGCGGGCGTCCTCGACGAGGCCCTGCGTGAGGGCGTCGTCGTCAGGGGGGCACGCGAGTACACAATACGTACCATTGCCGACACCTTCATGCGGGGCGTCCGAGATAAGTACGATGCGGCGGCGAGGCTGCCTGCCGCCGACAGGCTCAAGGTGCAGGACGAGCTGCGGGCCATGGACTCCAACCGCGCGTACGACCCCAAGAAGCACATCCTCTCCGACGTGATGAGGCCCCAAAACCCCAAGGCCGAGCGGACGATCTGCGCCGACCTCCTGGCCAAGGCCCCGGTGCTCGTCGAGATCGTGCGGAGGGAGCTCGAGAAGTGTCGCGAGATAGCGCGTTGCATAGAGGATCTCGAGCCGAAGGGGTGATCACGGACAAGAGCCTGACTGCGTCCTATACTCACGCCGGGGTCGTTGGACCTGGCCTTTTGTTGCCCCTCGGGGCGGGATCTAGGAGGTATAGCATGACCCATGATTCTGTGACGGTATCCGAGCTCAGTCGTCGCCTGCTTCTGGAACATCCCTCTTGGGCAGCTGGCGGGGCCGAGGTAGAGGCGCATCGCCTGCTTTCTGTGATCGATGACAGCCTCTCGCGCGCGCTTGCCCTTTATGTCCGCGATGGAGTCGAGACGGACTTCGAGGCAAACGGATTCTCCGTGCTCGGCTTGCGTGCGCTCATGGGCTCTACCTACCTCGAGGCCTTGGAGGTCATGAGCATCTCCCTGAGCGACCCGAAACGGGCACGGGCGATTGTCACGCGACGGGGGATGGCCCGATGAGCGGCTTCCCGTCCCGCACGCGATACGCGAACCTCACTGACCAGGAGCTGAACATGGTCTTCTCGACGGGCCATTGGGAGCGTCCTGACATGGGTTTCGAGGAAAGGCTCGAGGCCTGCCAGGAGCTGGAGATGCGCCTGGCAGACAGGGATGGGACGATTCCGCGTACCGTGATCGGTGAGGACATGCCCAATAGGGCATATGGCTATCAGCAGGGTGGCATCATCGCCCTGAACGCCCACATGCTTCAAGACGGAGCTTTCAAGCCTGCCTACGATGAGCAGCGGATGGCGCAAGCGGATCCGATACCGGTCCTGGCACCCAACTGGATGATCTACGATACGGTCTGCCATGAGCACCAACACTGCGTCCAGCATGACGAGGGACGCTCGCAGGGCAGTGCCTACATAGAGCCCAGCTCTGAGTACTCCTTGTATCGCATCCAGCCTTGCGAGCGCGAGGCATTCGAGGCGGGCGAGCGTGGGACATCGCGTGCGCTTGCCGACGTGCGGAAGGTCACTGGTGTCAAGGACCCCAACCAAGAGGATTACTACGCAGTAAACTCCACATATACCTATAAGGACGCTCTCAGGCAGGCGCAGGAACACTACCAGGACCCTGATATCCAGCAGGCGGTCGACACGGTGGTCAATGACTACCGCGATGGGGTGAGCCGCTCCTACCAGACGTCCGGCGAGCGTGCGGTCGCGCAGGTCCTCGACAGCCAGATGGCACAGGGCAGGGAGCAGGGCAACGAGGCCCAGTACCAGCCGGGCGCACGACAGACCGTTGACGACGCGATTCCGCTCTGGGAGGACGAGCCGTCGTCCGGCAGGGACAACAGCTCGCTTACCTGGGAGAGACCAAGGGAGAACGATCGGCACCAGGGGATGGGGATGTGATCCTGATGGCAATCAGACAGCAGGTCCTCCTTGGCGCGACGCTTGACGACGGACGCTTTCGACATCCGGGGGGTGAGCCGTGGTACGTATTCCAGGACGCGCGTGATGAGAGGAGCCACATGTGCATCAACGACGTGGCTGCATCCCGGCACGTGCTGCTCCTTGGGGGAAGTGGTACGGGCAAGACGAACGTGATGAACCTGATGTTCAGGCAGGCCCGCAAGCTCTCGGTTGCTGGTGAGGCGTCCTACATCGTGTTTGACACGAAGGCTGACTACGTGACCCACAGGGGCTTTCTTAGGGGAGGCGACGAGCTTGTGGGCAACAACCGTCGCTTCAGGGACATGAGCGCCGTCTGGAACGTCTTTGCCGAGGTGCTCGTCGATGGCCGCGACGCACGTGACATCAGGTCGAACGCCCACGAGATCGCGAGGACCCTGTTCGAGGGGAGGGGCTCGAAGACGCAGCCCTTCTTTGCCAACGCCGCCAGCGACATCTTCGCGAATGCCCTCGTCTACCTTACGAGGCGGGCGCAGGAGCGTCCGTCCACAGGGGTAAGGCAGCTCAACAATGCCAACCTGGTGCGCTTCCTGGATAAAGGCCCCAACACGCTCTCTAAGGCGTTTAACACGTACGATGACATGCGAGGGCTGACGACGTACTTTGGCGACGGGACCAACGACCAGGGGATGGGCGTCCTCAGCGAGCTAAGAAGCATGCTGCGTGACTGCTTCCAAGGCGTCTTCGCATCCAGTCCTCCCGCAGGCTCTGACGGCCTGTCGGTGAGGAGGCTGGTGAGGCGCAGGGGCGGACGGGCCCTCTTCGTGGAGTATGACCTCTCGCTGGGCCTGTCCCTGCAGCCCGTCTACCGCCTTCTCTTCGACCTTGCCCTCAAGGAGGCCCTGGGATCGAATGCAAGGGGTCACACGATTGTCTACCTCGACGAGCTGAGGCTCCTCCCACAGATACACCATCTTGAGGACGCCCTTAACTTCGGGAGGAGCAAGGGGGTCTCGGTTGTCGCGGGGCTCCAGAGCGTCGAGCAGCTTGATGCCACCTACGGTTCCGAGGAGGGTCGCACCCTCCTCGGTGGGTTCGGCTCGATCATCGCGTTTGGTTCTGTCGACCCGAAGACCATGTCGTATGTCTCCGACCGCTTTGGCGCGAACCTCATCTCATACCGATACCCCGATTCGAACGGCCAGCCCATCGATAGGGAGCGCGAGAGCAGTGTCGTCGAGCCCTGGAGGGTGAGGTCCCTTGGGCTCGGGGAGGCCATCGTCGGGCTCGCCACGCAGCCAGACCCGTTCCTGTTTCGGTTCCGGAAGGAGGGAAGCTAGCATGCGCGACACGACGTATGTGAGGCGGGTTCTCATGAGGCGCACATGCCACCTGTCGAGCCTATTTCCCGATGGGCGCCTCATCAGCTTTGGGGCATTTTGTGGGAACCCCTCGCAGCGCTCCTCCGTCGTACTGAGGGGCATGAGATCGGCCCTTGGTAAGATGGGTGTCGTGCTGCTACATACGGACCTCAAGCTCGAGGCTGCCGCCGCGAGCCTCTGCTCCCAGCTGGGAGTACCGATGGTGAGGGTCGGTGCCTCTGGCGCGGCGCAACGACAGGCGGGAGGCTATGATCCTCTGTACGGCCTCGATCGTTTCGGCGTGCTTCGCGCGCTTGGCGTTGCGGATGACCACTCCGCAGCCACGCATGTCGGCCACTACCTCACGATCCTCGACACCCTCTACAGGATGAGTCCCGGTCGCTTCGGGTGCTATGCCTACAGCCTCGGCGCGCTTCTGAGATTCTCCTCCCTGCCTGTCGTCAATCTGCAGACAAACGTCCTGCAGGCGTTTTCCTCGGCGCTATCCCAAGATCTCGTGCAGTCCATAACCATGCCGGGCGTCCAGATGGATGTGTATAGCAGGGTGTCTGCTTTGGCTCAGCGGCTCAGCGGCACCCTCTGCCCCGCGCTGGCCCAGCCCGGAATGTCCCTCCCAACGCCTACGACGAGCCTCGTCGCACTCTCCACCATGCGTGCGGTGACGAGCGTCTACCTTCCCTCGGGAGATGTGGGGACCCTTGACTACCTGGACGCTGAGCTTGACTACCTGGTTCGTTCGCACGTGCCGTTCATGCTCGTGCTGTCGGGCATCGACGTCACAGGCACTGATATGCGCCAACGGCTTATCAGCGAGAATGCCGGGTGCTCCTATACGGTGGGCGTTGCCTCCAGTAACCCACTGTCACTCATGCATGACCAACAGGACGTGGCCGCGCTCTTTGCTAAGCTGAACCGGATAGTCGTCTTTCCCTGTACGACCAGCCAGGTCGCAGAGTCCGTCTCATCAATCTTTGGCACATACGACCATGTGGTGCGTGACAGCAACGCCGGTGTCTCGAGGGGTCACGGGCAGCTCTTCGGGACATACTCCGAGGGGTATGTCGAGCATACGGTCAAGGAGCAGAACGTGCGGCCAGAGGACCTCATGGGAACAGATCGCGGAGCGCTTGTCGTCTGGGGAGGCGACCGGGCGCTCGTCGATCACTTAGACGAATGGAACTGACATGGTGAAGCGATGCGATAGGTGCAAGGTCGCCTTTGACGATCGGGTCAGCTTCTGCCCCAACTGCGGCTCGCCTTCGGTGGATGATACGCGGACCCTCGACGAGCTCGTGGCTGTCGGCTATCGGGCCTTCCATGGCGGCAGGTCGGCGGCGTTGCCCCAAGAGGCGCCCATGCCGTCTTCCGCTCCCACCGCTCACATAGAAGAGGACGAGGACGAGCGGCTGAGGAGGGGGTACGAGGACTTTGTGCTGCGTGAGCAGCAAGGGTCGACGTCGGTTGCTGGCTCGAAAGATGAGATGGGGGCGACGTCCGCACAATGGCTTGATTCGAGCTTGCATCCACTTGTCTCGAGCGAGTCTGCCGCAGATCAGAACTGTCATGAGAGTGACGCCGATCATGTTGACCGGCTGATGACGGGACTTGGGCTGGGGATATCGCCCGAGGCGTCACCTGGCGTTGTCTCCTCGCAGGAGATAGTGCGTGAGAGCGGAACGTCTATTCAGCCGATAGCAGGCCAAGGCGCGGCTAACCCCGACTACGACCTGGTTTTCAGCGACATTCGTGTTGAGCACGAAAGGCCTAAGCACGAGCTTGCGGAGTTTGTGAGGGACAATGCCTCCAGTCGGTTCTTTCGGGACCTCTTCGTCCCGGGAACCGTCTTGAACAGGATAGGGCGCGCGCTGCTTCTGGTCGTGGGCATATGGCTCACCATCGTCCTCGTCGTTCCCCTTATGGTGGGCATGGCGATCAATGCGTTCGAGGCGCTGCTCCCGCCTCTGCTGTGCATCGGGTTCTTGTGGTATCTCATGCGAGGTATTTTTCGCAGATGATCTACTGACGCATTTCGCGAAGTTCATGGCGTTAGACGCCATGACGTTGTGATTACTCATGGAGGGGACTGTGTTAACCCTACCCTGATACGGCGAGTTCGGGGTGGAACGGGTACGGCGCGGCGACTCTCTGTCTCCACGTCAGTCGATGTGGAGGGCATGGGAGCTGCTCGACGATCGGGTCGTCGGGGCGACGAGCCTCGTGCAGTCACGCGAGGTAGCCGTGGAGTCTCCTGGTGGACATGTCACGGAACCTGGCAGGGAACGCCTCAGGTGTCGAGTGGGTCGCGCATCACGAGGTCGGGCGGTGCCCTCGGTCCCGAGGACGCGAAACTCTGGTGCGCCGCCACGCCCATCTCTGCGAGCGCGGACGCAAGTCCCCTGCCTGTTGGTCGACGCGACAGCCCGGCGGGTGCGCACTCCGCGAGAGCCTCCCTGGCGCTGCCGACGCCGAGTCTTCCCCTGCAGCCGCGCGTCGTCTCCCTCGGGCGGCAGCTCCTCCGCCATCGCCTGCGACAGCAGCCCAGGCATCCTCTCCCGCTTGTCGTCGCGCATCGTGCGGACGATCACCTTCAGCCCCTTCGCAGACATGCCGCCTTCCTCACCTCCGGGTGTGGGAGAGGCATATGACTGTGGGGTCAAAAATATCAAACGGGGGTTAACGCAGCCATTGACAAAAAACTAGGGCAGGACTGCCTTCGCAACCCCGCCCCGCAAAACCCGAAGGTTTTTTGTCTGATTCCATTATGGGTGATTACACCCAGTTGTCGAACACCTTCGCAAGAAATCTGTAAGCGGATACCACACAATCGGTGTTCGTGTACCAGTCGGCGTGCTCGACGGCACGATGCTTGAGGGCATCGACCAGGCTCCTGCACATCTCCCTCGTGTGGGAGCCCGCGACCATCTCCCTGTAGGCGAACGCCATCATCGTTATCTGCTGGACGCGCGGGTTGGCCATCTTCGCTCGCCTCGCACGCCTATTGATGCCCATCTCGTCGAGCGCCAGCGCGACCTCTCTCGGGGTGCGGATGGTGCTTGTCTCGCCTGGCGCGAAGCCGTTTATGATGTCGGTGGAATGGGCGCAGGCGTTCCTCACGGCTTGGGCTTGCCTGAAAAGGTAGTGCTCGCTTCTCATCCGCCGGTCCTTCCACCTATCTGCGCAGAAGAGATAGAAGTTGATGAAGCCTCCGAAGGAAAGTAGCTCGATGAGGACCCATACGGGCTTCTCGTTGTCGTACTTGCGGGCCATGCCCCCGCTGTACCTATCCCTCTTCAGCCGCTCCATCTCCTTCTCGCGAATCGATCGGTTCCTCTCACTCAGGCTTTCCAGGTAGTCGGCGACGATCGAGTAGCCGTCCTCGTCTGCTCGCTCGGTGACCTCGCGCATGAGCCTGACCTTGGCAAAGTGCTTGATGTCCAGCGTCATCGGGAGCAAGGTGTACCTGAGCATGTGGTCGATGGCCGCGAGATCCCGCAGATGCCCGAAGTCGAGACCGACGTACTCGCTGCCATGCGCTCCTCCGATGCGCTTTTCAAACAGGACGCGGTAGGCCGCGAGCTGCCTGTTACCGGGTCTGCCCGAGCCCCTCGACCTGCACCTCTCCTTCGCCGCCCTGACGTCGCTGTCCCCCTCGACGCGCGCGCAGGAGTCGGGGCCCGTGGTGGCCGGGCTCGGTGCCGGTATCGCGTACCCTCATAGGGCGGCATGAGGTCGAGATTGCGAGGACCTGTCAGCTGCTCTCGTGCGAAGGGTACGGGTGCCCGTGAGGCGGGCAAAGGTCGACGCGGCGGCCGTGGGGAGGTGCGAGCACATGCGGAGCGCAGGTGGGGTCACGTTGCGAAGGTGTGGGGAGGTCCCCATGAGAACGCCCGCTCACCTGCCTTGCAGCTTATGCACGAGCTCGGCGAACTCGTCGCGCCTCTGGGCTGGGGTGCGCGAGTCCTCGCTGGACTCCCTCATGGCGTTTGCCGCGATGGCGCCGAGGGCGCCAAACGAGCGTCCCAGCGCGGCCTTGAGAGGCGAGAACTCAAGGCGATACTTCGTGCCGTTCATCTTGATGGAGTCACCGCTCCACGTCTTGAGCTTCGCTTCCACCTCGCCTATGGGTGCACGATCGAACTCGTTGCCCTTGTTGTCAAAGAGGATGAGCTCGCCTGAGCCATCGATGCCTATGAAGCCGTTTGTCGCCCGTTGCCTGATGCCTTGGACTATGTGCATGCCGTCGCACCAGAATTGCCAGTCGCCCCTGTTGTCTGCCATGGAGTTCCTCCTGAGGTCGTCTGTTGACAAGAAGTGAGCCACGTGCTAGCAGAGAACTATACCGTAGATGGCATGGCGGCATGCCAGCTGCACAATATACGATGCATTCTGCAAAGGAGCGCACCCGGTGGGGAGGTGTGTCTTGCGGGGCACGGTGCACCGGACGCCTCCCGAAGTGCTGGGGGCGGTTGCCCCTGCCGTGAGGCTGGGGGGCCGACAGAGGGGGGCGTGGGTGACGACTTTGGCAGGCGGGGCATCGACAGCCCCTCCGACAGGCGCTATCTGCTGTAGCTCTACCGTACGGGCATCACGGCGATCACTGCGCGATGGGTGGAAGGCAGGCGTGCAAAGTTCGTCGAGCGCACGGTCACGCTCATCTCGGGCTGCATCCACAAGGCGTGATGCGAGTGGCGTGAGGCGCTTGGACATCGGCCATCGGAGGGGCTGGGACAAGCCGCCCTTGTCGGCAGGCGTCTTTCCACCATGCGCATCTGGCCATTGGGAGGCGCGAGGCAGGTCAGTCGCCCTCCTCCAGATATCTCCTTGCAGCCCTCTCGTCCGCGATCATGTACGTGCGCCAGCGGTTGGAGCCCTGTGCAGCCAAGATGCCATCGCTTACCAGATCGCCGAGCAGCTCGCTTGTCCGTGACGCGCCCAGCCCGGTTGCCTCCATGATAGCTGCCCTGCCGAGCGGCTCTGCGGCTGATGCGATATGTTGAACTATGTGGCGCTTTGTTCGATCGGTTGCCTTCGTCCGATTTTCGCGTCCGATTCGTTCGAGTTTCCAGATGAGACGAGCTCTACGTGCGAACCTGGACGGTGGAATGCCACACGCGTGGCGTTGCCCTCTTGGAAGTACTCGAAGCTCACGCCAGCCTCGTCGCAGGCCTGCTTGATGCGGCGCAGACCACTACCGAATGCCTCGATGTAACCGCCGCGGAAGAGGGCGTCGGCAATGCGTGGGTTTCGGTTCTGTGGCGCCCTCGCCACCCCCTTGAGGTAGTCGTCTGGTGTGGTGCCTGCAGGGAAGAGGCCGGGATTCGTGATCTGTACCGTGTCCGTAAAGATATCGATCATCACGCGGCTGTCACCTTGATGCTCTTTGTGTTATCGGAAGCCCCGCGTTATGAGAAGCCGCCAAGCAAGCCCGCAGGTCGCGGGCTTTTTTGATGCCCGACGGCTTCGCATAACGTGACCGTGCATCCATAATCGTTCCCGTATGTCCGACATCGAGACTGAGGAGGTCAACATGGACGTACGGGAGTTCGAGGAGTTCGTGCCGTGCGTGATTGAGCGCATGCGCGCGGACGGCTGCGCCGAGGGCCCCATCGGCACGGCCGAATGGGTCCTGCGGTGGTTCGCGGAATTCTGCCGCGAGGAGGAGGTCGGCGACGTCGGTGATGACGCCGTCGCCGACTTCTGTGCCAGGCGCTTCGGCTTCGATGCCGGCGATGCGAAGCTGCCGACGCGGACGGCGTTGCGCAAGCCGCTCCTCACTGCGATGGGATCGTGCCGCACCGGGTCGTACTGCAAGACCCACCAGCCAGGCGTCGTCCACGAGGTGCCGGAGTGCATGAGGGGGGTGTATTCCCTCGTCATCACCGACTTCGTCGGCGAGCGGCGCGAGACCGGCCTGAGGACCAAGGAGCGCAAGGCCTGGATGGCGGCGAAGTTCCTGACGTTCGTCGCGGAATCGGGTGTGGGCGACATCGCGCGCTTGCGCATGGAGGACGTCGACGCGTTCGTCGGGTCGCTCTCCGGGTACGCGCCCGCCACGCTGCGCTGCCTCAGGGGGACGCTGCGGGAGCTGCTCGACTGGATGGCGGGGCGCGGGATGGTGGGGCTCTCGGGGCGCATGGCGTTCCCCGTGCCCAAGGGGAGCAGCCGCTCGACGGTCCTGTCCTACTACACGAAGGACGAGGTGGAACGCATCGTCGCCGGCATCGACGCGTCCACGAGGAGGGGCAAGCCCTGCCTGCTCGTCGTCGCGCTGTTCGCGCTCGCCGGGATGCGGGCGGGGGACGCGGCGAGCCTCACGCTATCCGACATCGACTGGGACGCGGGCCTGATCCGCATCGCCCGGCAGAGGACCGGGGAGCCCCTCGACGTCCCGATGCCCGACGAGGTGCGCTACCCGCCCGTCGACCACATGCGCAACGCCCGCCCCGACAGCGCCAGCGGCCCCGACCACCTGCTCGTCACTGTGAACGCGCCCCACACGCGCATGCGCGGCGCCGGCACGCTCGGGCGCATCGTGGGCCGGCGCGTGGAGGCCGCCGGGGTCGAGCCCGGCAGGCGCCGCCACGGCCCGCACTCCCTGCGCCACTCGCTCGCGACCAACATGCTCGCCGCCGACGTGCCGGTGAGCGCCATATCCGACGTGCTCGGGCACGGCAGCGCGAGGACCACCGAGGCCTGCCTGACCGTCGACCTCGCGCACGCCCGGGACCTCGCGTCGGGGGTGCCGCCATGATGTTCGACAGCAACCATTCCCCCGACTGGGTCCCCAACATGGACGGGCCGTTCGCGGAGGAGCTGGCGGCCCACGTCCGGCACAAGCGCGCGCTGGGCCACCGGTACGCCGAGCCGGTCTGCCACGCGCTCAAGAAGACGGGCCGGACGTTCGCCGAGATGGGCTGCGACGGCACCCGCATCACCCGTGAGACGGCGGGCGCGTGGTGCTCCGCGGGGGAGGGCCAGACGCGCGCCACGCTCGGGAAGAGGCGCACTGCCCCCCGACGGTCTCGCCAAATACCTGATCTCGAGGGGCTGGGAGGACGTGGCCCTCTGCGAGGAGGGCGGCGCCCTCGGCAGCTCGTTCGCCCCGCACGTCCTCGGGCGCGACGAGGTGGCCCGCGTGTTCCGCGCGGCCCGGGCGTCGGCGGCCGGCGAGCGCGCCCACTCCCGCTACGCGGCGATGTGTCTGTGCCACGCGTGTGGCCTGCGCCGCTCGGAGGCCGGCAACCTGCGCGTGTCCGACTTCGACCCCGGCGCCCGGGCGGTCGCGGCCGGGCATTCGAAGAGTGACGTGTCGCGCCTGGTCGCGATGTCCGAGTCGACCGCGGAGGTCCTGGCCGAGCACGCCGCGATGCCCCGCGACCCCGCCCCCGGCGCCTTCCTGCTGCGCGGCCGGCACGCGGGGCGGGTGGCCCTGCCCGTTCTGGCACGACTGCCTCGATGCCGCGGGCGTGGTCCCCCGCGCCGACGGCAGCCGCCAGCGCCCGCGCGACCTCCGGCACACGTTCTGCGTCCGCGCGCTGGAGAAGATCGCGGAGGGAGGCCGCGACATACGCGCCGCGCCGCCCCTCCCCGGCGCCTACCTCGGCCACAAGGGCATCGTCGAGACGGAGCGCTGCCTGCGCCTCGTCGAGCCGGCGTACCGCGAGGTGTCCGACGCGGCGGCCGGTGGCTTGCCGGACTTCTACGGGAGGGGGAGCCATGGGCGAGGGCAGGCGGGACTTCGGGTACTACGCCGAGCGCTTCCTGGGCGACTACCTGACGGCGAGGAAGGGCTGCTCGGCCAAGACGGTCTCGTCCTACCGCGACGCGATCGTCCTGCCCATGGGGTTCACGCGGGGGCGCTGCGGCGGGCGCTTCGGGCTGGCCGACATCGACGCCGGGGCCGTCGGGGCGTTCCCCGACCACCTCGAGGCCGACCGGGGCAACTCGGTCGCGACCCGCAACCAGCGCCAGGCTGCCGCGAGCCCGTTCCTGTCGTTCGTGCGCACGCGCGAGCCCGAGCCGTGCGGCCAGTACGCGGCAGTCCTCGACATCCCGAGGAAGAGGCCGCCCAGGCCGGCGATTGCGTACCTCACCGTCGCAGAGGCGGGGGGCCGCTCGCCTCGATCGACGAGTCGGACCGCCGGGGCCTCCGGGACAAGGCCATGCTCGCCTTCCCCTGCGAGACCGCCGCGCGCGTCGACGAGCTCTGCGGCTGCCTTTCCCGCCAGCTGCGCCTCGAGTCGGCGCCCTACGCGGGGCCGCGCGGCAAGGGCGGCAAGGCGCGCAACGTGCCGGTCACCGAGTCGTTCGCCGAGCTCGTCGGCGACTAGGCGGGGGCGTTCGGGATCGGGGGCGGAGACGAGCCGCCGCTCGCCAACCGGTACGGGAGACCGCTCACGCAGAAGGGCGTGTCCTACGTGCTCGGCAAGCGCCTGGCCGCCGCCGCCGCGTCGATGCCGAGCATCGGGCGGAAGGGGATAACGTGCCATTCCATGCGGCACTCGCGTGCGACGCACCTGCTTGAGGCGGGGGTGAACCTGATCTACATCCGCGACATACTGGGGCACGCGTCGGTCACGACGACCGAGATATATGCCAAGACCAACCCCGAGCTGAAGCGCAAGTACCTCACGGAGCACAGCGCCACCCACTCGACGGGCGAGAGGTACACGCCCGAGGAGAGGAACGACCTCGTGAAGTGGCTGAAGGACAACTTCTAG

Protein sequences of DBSCAN-SWA_2

>NZ_CP012069|946274:1016854|995043_997602_+|WP_157051392.1|DBSCAN-SWA
MDYQQLCYARVGCQGVGSGWQVLNVSPGVSALARSVYPRLQSGNANTSADVPSEEGQLPQVLELRSEGELVFLTMVTYGVADELGRPSSFSHGLVFGRDEFERDPQLALRVRRTSFGHTLEDTLPERLRVSLAEPMGLALARETCGLDLTGHGSLLLCVCEALGLDGRLGRPFRILCDCEPRTIHAVLTCIYQSIPYGLRGRVSFSTFQTNGGLPVDVVFSKDDQGRGFDLARGAMRGGKPRETSVAGPERRLPAFAAHVLRTEVSEGELSRYLGALEDEVQTFCDPNEASVFAYEAAYDRLVKSGVIERLESYERPLDPESIVRRLLCSMGLPKSEDASRRAERDGLVSGALRDVVEHSVALDDWVYDEVAREAEDSKLDSLEDARFDYDTSVRFAGKTPEEGAAYLAQEYPDAASRSTAEFLRLRFALAGRPASKDVLIRYYERLADKLQGPGGPSLDDIRSFHDETAILEDSCIDERVAALCEAHAVARVVPDGDPVELDKAIKALFSQVELSEDAKARIRGAVAVAYWRSFSFKAFNFRWKTYKNSVVNQEDVCKGQQEYLAALLASRVGQYIIRTQYELLARSYRVLERALERLEGEKSEALRERLAAYLRKWARAGAHPQDFDTLCRVAQAICNPSEGAKAPQVSSTSPRGSDVQAVCDPGDNAKAYAYMLESGMLPDDPAALRAMLDHSRVLREDGERKCLLEQCKRMSRQRRSPVSKHAKDVARALRSHERESRRSRKPRHAEPVLRHGARREGRDVPANAGPGTLARLFGFGGRGDREPHREDIGTRGFEPPEGEDLTARRLNGLIKPTEVQGATGGSSDRVGSSGSHSIKGSRKQGSRDGKR
>NZ_CP012069|946274:1016854|999302_1002323_+|WP_050343806.1|DBSCAN-SWA
MPKNSFHSFWGGITDEVWQCAQDDFAALAIGLGGTGIDCLRTLKKRVYERLRPDNPGDAVPRYDHIKFLAVDSDAVGMKKVADSSGHAPYKLDMGTEFFDVSCANNLSGVFGRNRVNLARDPAYREWLQFDDLNMVGTATDGAGGVRQVGRFLLVRRASEFVSTVHDMVTEAMEDANDNKRKVYVHIFSGLGGGTGSGAFLDACYLVREALRRAGVQDCMLMGYLFLPDVNLANTAIPPNVRKYIGHNGYAAMQELDYCMGFGRNGDAWRQAYPGLGEVRCEAQPVDFCHLVGGKTSQGVPLPDAYGHAISVVADCVTDTLVRPASPSYSLESLLSNVETIRSSMRGMQDAGACYDYLVLGASCAVVPYGRIMTYLASGLFQRPEGLGMRGRVPTEEEVERFQEDVGLTHDALLRELRRGVGVDPGHYNAMPAGAQKKSPNVEDHYMKLEAAARGALGRNLADLSRGVPGHVRTKLPTDGRAQAVMAKVVNAVLDAMVDPERGPWYASALVRSAKGTDLLAAAWGIRAEAERRRDHEAAQDEEGMPIWDDFARARDEFFSCSFPPFLKGKYDAFVEAIRVLTFCHIRRDSYEALAKLAGMLGRQLTDLADELTDPFERVMEGLIDTFGANWSYLKAFVDGASTYEQPIVTMGQIAPVLDGEIKKCDVGKVTQGLLDALLGEGGRAAWGPGGDDAPLARLVSRYFAGTFRGPLRSLEGYLEDRYGIRNDPKLLAKRVQDDLLKKMDRRAEVLFDTGWRYDLPDDGPALCCVTVPQGSPVVANAAAGYVAAQGAGYSVRMTSATDRVSFLRLKFGVSLWGYAGLARCEAGYEPAPGRHLYERAVCVEGVSDPAEVEASRDWRELPSPTPRSKMGQGTDPEVRRRADEAAGVLDEALREGIVVRGIGEYTIRTISDGFMRGVRDKYDAAAKGLPADDRLKVQDELRAMDANRAYDPKKHVLSDMMRPQNPKAERTICADFLAKAPVLVEIVRRELEKCREIANCIEDLG
>NZ_CP012069|946274:1016854|947038_948226_-|WP_050343736.1|DBSCAN-SWA
MGEPDNPFNPGAGRRPPLLTGRDRLIASMHLDMGRVVSKREEGRPCVIWGLRGIGKTVLLNELAEHARNSGWIVILTEATERESLSQRIAQATYLELRQIRTRSKRITDTLARAVRVLRSFQLTIDPSGSYSIGIDVEPARGYADTGNLSLDLQDMLRALGDAAHASSTAVFLGIDELQEAGQEELDALNVALHTLGQGNEQTPLFFCGTGLPTLPSILAKATSYAERMYRYHQLDLLSNEDVRLALQEPCERLGVSWDEGAIQRVTAVSAGYPYFVQSCGYFAWEQRTSSTLISDEDAMIATRLAQDEVDSGLYRSRWDRATDAQRRFMEAMSLDEGASLMDDLARRLGRKPSSLTSVRKRLVDAGLIYAPRTGQLDFTVPGMGRYIQRVSNGR
>NZ_CP012069|946274:1016854|993391_995011_+|WP_050343798.1|DBSCAN-SWA
MGDKDAGKNITCPFCFKTFKDWQVHFRMEVREDNPLFEPQKDQKYEDFWSEYGGTTEYGESDEVPPYFHRVYDPCDPGHKNAFIKEDPQADPPRTVLVRDVDGMVIGARDSFGKVTRERVCPHCHNLLPGAYGRKPVKFISFIGITGAGKTVYLSQLCRFMPAQLGAYGVSVMPTSQYANDYMNKNKVVMGEKLPDSTNPKRLLQPLCFDFTFSDPDGKQHTQTFVFYDIGGENLEEKEGEKLAAQAQKFGRFILHSDALILLINPVQFTGMNRDAIAKDDEESKGNDEPLNPATALTVIYNLFNQGLNPDALKNIPLAVCISQADKPLNGMDSACQYIAEGESLSGMRGAPIPGSGALVFNAADYNHWQTYIDSFVNLLKSGANELGTKLNNGYECYNYFMIESIGVPLEKKSESSGTVYQVPSKQPVPKRIIEPILWILTILSIDGSGRPAVAVEGKINEPKGWRCPSCNKWCSDTVTFCPKCGVNKKGEWRCRKCKRLNPRSAEWCESLCCNTNRSGGSRGFFAGLFSRISRGRGA
>NZ_CP012069|946274:1016854|1013132_1013489_-|WP_050343827.1|DBSCAN-SWA
MIDIFTDTVQITNPGLFPAGTTPDDYLKGVARAPQNRNPRIADALFRGGYIEAFGSGLRRIKQACDEAGVSFEYFQEGNATRVAFHRPGSHVELVSSGNSNESDAKIGRRQPIEQSAT
>NZ_CP012069|946274:1016854|952907_954524_+|WP_050340583.1|transposase|DBSCAN-SWA
MPFIKVQKLVRDESGAIRSGSAAVVDTSYVRGAKYHSAQAVRERLGKVVWLADDRRSGVFASPTRGLVEYDADADGFAPVAKGDERLANTGAFPEPPRHLELGPEHLLLSFLGADGVAGCLREALPDDRSYQRALAHVTHGVVRDGSRETCDNMVARSFAALALPGVPPASLRSDTAFFSAMGADGAKVAFFRAFARLMRRTKPGFGRACYVDSTPLPNDAVDNPLNALCSHGLRGAAVQMRLALVLDETTGLPVWYEVVPGNVLDLSTIKTVMGDVLATLGIEVVTAVLDAGYASRELLEAFSEGERDVLVRMPARRGYPYRELWRGVRSLIGKGKYAITRSGHLYFARRRDVEVQGVRLHCYVYVDQTNATPRFARWLDKNQERFDGMSLAEKDWETVRQGYFVLMSTKVATPREILDEYFCRTEIEGVFKTSKDYLGLLPLRKWSDLTVRGKILADIIGTIVVLRMRKALAGADVSLTEVWGKARSLSCYTNADGRVVVETPSRQVREYYKALGVKVPSSIDVREFDRDVLGLEL
>NZ_CP012069|946274:1016854|951327_952695_-|WP_050343743.1|DBSCAN-SWA
MKPSFEGQGSLFDTTDEEVADSSAPLAARMRPKTLDEVSGQTHLIGPGNVLRRMIEADQLPSMIFWGPPGVGKTTIARVIARQTRAEFITFSAVTSGIKEIREIMRRAGAQTHTGRRTIVFVDEIHRFNKAQQDAFLPFVEEGAITLIGATTENPSFEVNGALLSRCKVFVLKGLTKEEVEGLLRRALTDERGFGGQEVRIADDLLDAITTFANGDARMALSTLEMVVLNGDTEGDVVTVTPETVRQCTGQRSLLYDKTGEEHYNIISALHKSMRNSDPDAAVYWLARMLESGEDPLYVARRITRFASEDVGLADTNALNVAVNAFHACHFIGMPECSVHLTEAVIYLSLAPKSNSSYIAYERAKKDALHSMAEPVPLVIRNAPTRLMKDLGYGKDYRLAHYEKHKVAANMQYLPDSLAGSEYYHPTCEGREAWLSERLSDVKRWRAGTPDDTQE
>NZ_CP012069|946274:1016854|1016296_1016464_+|WP_172674439.1|DBSCAN-SWA
MLAFPCETAARVDELCGCLSRQLRLESAPYAGPRGKGGKARNVPVTESFAELVGD
>NZ_CP012069|946274:1016854|1005535_1005850_+|WP_050343811.1|DBSCAN-SWA
MTHDSVTVSELSRRLLLEHPSWAAGGAEVEAHRLLSVIDDSLSRALALYVRDGVETDFEANGFSVLGLRALMGSTYLEALEVMSISLSDPKRARAIVTRRGMAR
>NZ_CP012069|946274:1016854|957524_959249_-|WP_050343750.1|DBSCAN-SWA
MFAIVKRILALSGAYRPRVIAGIVFSTLKSCCAALPFFALLLIMANINTLTATIIGQAFTIVTLSVAGRFLFQYLTNITMSVAGYDIFRDRRLEIGEQLKRAPMGYFTEGNLGTIQTVLTTTISDLEGNCMLALTFLVGGFAQALAMTLMLCLACLPIGLVSLASILAGTAVLALIRRRAGAHTKDMQGAQERLVGSALEYIRGISILRSFGKGRESKGKVDEAFENKLRSDLEVTHATAGAMKLYEAVFKIASCLMFLVAALLYLRGTISLSSCLLFIVCAFIVFMELELLGDGAFLSKLLTTQLDRLDSIADIPLLDEGGDDIAPASYDIEFKDVAFAYGSREVLTGINLNIPQNTTCAIVGPSGSGKTTLCNLIARFWDVQSGSVFVGGHDVREYTCGSLLSLVSMVFQNVYLFHDTIESNIRFGRPEASRTEVIEAAKKARCHEFIEALPDGYDTVVGAGGSTLSGGEAQRVSIARAILKDAPIVILDEATSSVDPENEKELLSAIRELTRDKTLISIAHRLSTVRHADQIVVIDQGKIAQKGTHEQLASQDGIYSRFIRCRTQSIEWRL
>NZ_CP012069|946274:1016854|979243_979693_+|WP_050343780.1|DBSCAN-SWA
MRSPHTYAEWVEVIDIFGNRLDDDGAISAMRSGTLDWQAGVSDRFLQKLIGAVNKRMNAAVDAFQKRQRRSVADERSITEALLAFRREFITLMNAVDIPAMPEKYREECRSLIRGQADANQSSLEDSAPRVDRSGKLLSIIHKTPVNKF
>NZ_CP012069|946274:1016854|1015191_1015911_+|WP_172674438.1|integrase|DBSCAN-SWA
MALCEEGGALGSSFAPHVLGRDEVARVFRAARASAAGERAHSRYAAMCLCHACGLRRSEAGNLRVSDFDPGARAVAAGHSKSDVSRLVAMSESTAEVLAEHAAMPRDPAPGAFLLRGRHAGRVALPVLARLPRCRGRGPPRRRQPPAPARPPAHVLRPRAGEDRGGRPRHTRRAAPPRRLPRPQGHRRDGALPAPRRAGVPRGVRRGGRWLAGLLREGEPWARAGGTSGTTPSASWATT
>NZ_CP012069|946274:1016854|982173_982413_-|WP_172674437.1|DBSCAN-SWA
MREASDAGKDDAKERLHALVESALKVSGITGETSFCGELGVDSMQLVVLLLACYWRSRENSRSPFPTVASWLPVQPLAR
>NZ_CP012069|946274:1016854|955319_956012_-|WP_050343747.1|DBSCAN-SWA
MIQSVGLRYDPRVKLLLVLLTSTLAFSLGGGVTGALLFGIVLLFALLAGIWKDALAYVAVYVLLFLLAQVVPAHLASVIQFFFLRMLTIALGLSLLFQTTEISELISSLRSSHVPQVVIIPFAVALRFLPSIMQDAIYIKQGLKTRGVGLSLRRVLAHPAQTYEAFIVPILMRVLMTATELSASAETRGISYPCEKTQYQIAEFSPKDGLLVALMTALFALVVGVSLSMR
>NZ_CP012069|946274:1016854|961067_961715_-|WP_157051389.1|DBSCAN-SWA
MIIKGRRCVTYCSDLTRERILECAKAEFLAKGYRAAQLKSIASAAQVTTGAIYRHFKDKNDLFLTLVKEVSEFTVARLDRDGCDAAGIQKALDSDSVEQTYAQVMDYIDYMYEHCDEFRLLLKCAQGSSAEDFTETISERYAAQNMAFIDAAYETGLASHRPSETEVHMLTRGYISAVCECIVRDIPYEQAKDYIKSIVTFHHYGWYGILGLSAK
>NZ_CP012069|946274:1016854|956008_957517_-|WP_050343748.1|DBSCAN-SWA
MQGGAQEPLIRFDDVSFQYEGQDKRSLQNVDITIDAGELVLVTGESGSGKTTLTRCVNCLIPHFFRGELSGEVLVGGRSIKETTPGDAGKLVASIFQDPRSQFFTTSSDGEAAFACENYGVAHEEIVRRVDDSFATLGMGDLKGKSIFSLSSGQRQKVAFIAAATLNPGIYVLDEPTANLDSATVLQVRDVLAALKEAGHTIVVSEHRLFWLAGLVDHIIVMRQGRVIEDSAGSHMELMTADALHDKQLRAFDLGSLRHASPPAPPCRGDVFLRASHVRFSYRGEPLLLDDVSLSAWKGEVIALIGRNGSGKTTLGKVLAGLIPCRNGRFVVAGSQVRQKRLSDYAYFVMQEADHQLYKESAVEELRLGNERASDIDERIAGILDMLNLTDFAQHHPYALSGGQKQRLTIGTAMASSKPIVVLDEPTSGLDWGNMCAVAQAINQLRESGRLVFVITHDIELVDLTATRVLALAEGRIADDFPLSSQAALERTRQIMLGGGLL
>NZ_CP012069|946274:1016854|1006757_1008092_+|WP_157051393.1|DBSCAN-SWA
MAIRQQVLLGATLDDGRFRHPGGEPWYVFQDARDERSHMCINDVAASRHVLLLGGSGTGKTNVMNLMFRQARKLSVAGEASYIVFDTKADYVTHRGFLRGGDELVGNNRRFRDMSAVWNVFAEVLVDGRDARDIRSNAHEIARTLFEGRGSKTQPFFANAASDIFANALVYLTRRAQERPSTGVRQLNNANLVRFLDKGPNTLSKAFNTYDDMRGLTTYFGDGTNDQGMGVLSELRSMLRDCFQGVFASSPPAGSDGLSVRRLVRRRGGRALFVEYDLSLGLSLQPVYRLLFDLALKEALGSNARGHTIVYLDELRLLPQIHHLEDALNFGRSKGVSVVAGLQSVEQLDATYGSEEGRTLLGGFGSIIAFGSVDPKTMSYVSDRFGANLISYRYPDSNGQPIDRERESSVVEPWRVRSLGLGEAIVGLATQPDPFLFRFRKEGS
>NZ_CP012069|946274:1016854|997588_998743_+|WP_050343803.1|DBSCAN-SWA
MGNDEMTAGLDTGKDSLISVMYAPHLAYVTRGKTVASPGGERRLVDAVPRAGHPAQIGAPLAKERLFLVPIDSLFHIPRVSPGEGMTPMRRERREILQHWNSIIIYPKERSDWWLRGVPEHPLRSHFDWPVDVAMTTDRERSFLVFPLASDAGRLRPLSELMVNLDDGRPPLEFGQEIADHRDLRIALARSLVEAWGQLRSCGYCYGCYDSSNIFYDPKAKEVRFGFSMATRYLPDGDAESPSPIAVSKGARESLMFDYIDPVSYGPIREAVDHGEQPSAILSRTDDFVMWAMAFRLLVGRLPFYGPSALTVPNTSGEDHLRWIDQYQKNAVFIFDSTDDSNQVGGRDGFAGEEVFRENWEAIPDDLRDEMFDRFDSGGTAAAS
>NZ_CP012069|946274:1016854|1016542_1016854_+|WP_172674440.1|integrase|DBSCAN-SWA
MSYVLGKRLAAAAASMPSIGRKGITCHSMRHSRATHLLEAGVNLIYIRDILGHASVTTTEIYAKTNPELKRKYLTEHSATHSTGERYTPEERNDLVKWLKDNF
>NZ_CP012069|946274:1016854|967417_967600_-|WP_157051390.1|DBSCAN-SWA
MPGASLRSICAAAHVTTDALYFLFAGKGELFERALGPSFDQVALVLAHSLPARADQPHAG
>NZ_CP012069|946274:1016854|967955_968222_-|WP_050343764.1|DBSCAN-SWA
MRVLTETEAYEEERFPETSRMKRRLRETEEGREDMGSVIEEIRAEGIAEGKLETLVRLVRDGLVSVQDAATSVGVDADEIRRALAAEG
>NZ_CP012069|946274:1016854|990619_992635_+|WP_050343795.1|DBSCAN-SWA
MKKDDISKLISDAAATLHSKGNDGMKKYVGVEYPACVLYYGESTSSFHNGILEALQSEWGIVASIIPFYTILNPDLSGRHALKDMQTSSDADVKAFQRTVMNVQGAKNSNFFNDSTVLYTFCVVDTRGMGPEDFHDWYACIESIQDLLDGVTLKTLLIVLLNNSVGDANASSITQKLAEIYEGEELGPANGHLYEGVLLYGNQSWNKQFNGLFDEQVAWEHGDWNVLADVIMLTNSQYDATTPNFNAVSSLRRLLFSTRVHPAVTVALKQVEKPCGDIATVSLLHVVRQLDASFTAMKGVPLNELSVLQALGCNENGYFQFTDYLNEQIDEIEKNTFRGFEDGLPLSIESAPLTNTPDMGKLSYGEADDKTSGCLSAFVENNHLRQIDRVLSDGSNGIDKLMRERVTSTLTAPQLLSLSKSAWEQYIEKAFVGARAYDPKRLKVHDAIDRKLRQRVAERAHRCVLEIISELYDKAGQVEREFNALKSDVSLATSKVDPNLDNFYGKIVNSFCISGGLQEVQQLVFTSDGDRKTMIEAIRTKGLKNLFSYAIDRQNIFSLGFMDELTLRMADGKAQAAAQTVIGADLVKNISGQVAYRSIFPLSSQQVEAYLLHVDTNAVGIDRASSSGKLYSYLNKRAIPNGTSRVFLNIGRRDSASSLWFYALDTQHLRG
>NZ_CP012069|946274:1016854|981437_981929_+|WP_050343783.1|DBSCAN-SWA
MPRQLLNVHANSRRQQQLDVQSSSKKAQQKVNPVTFERALRKHRSKRYIELMKKLDAGGHVTNQQQVNYLIAALRNELGELDESLSDSLRGIVSKCYLGDPYEVHTLDVAQCIIDHYARGERLPGTLEKVRGIAMLGGYDFIEVYDGYFCAVSDSGSVSVIRG
>NZ_CP012069|946274:1016854|949816_951178_-|WP_050343741.1|DBSCAN-SWA
MLERKVLDHMRRWKSRARGREALLIEGARRVGKSTAVEQFAKNEYRSSIIIDFSRLPRDVRSIFEDQRDDLDTFFMLLSAYYRTPLHTRESLIVFDEVQLYPKAREMIKHLVADGRYDFMETGSLISIKRHIKDIVIPSEERKLEMDPLDFEEFCWAMGEKLLSDLIRNSFETSRQLPDALHKRAMRLWREYLLVGGMPQAVNEYVQSRDFNEVDYIKRGIIDLYLNDMGKLANGDAGKLRSIFSQIPGQLSKHEKKFTLASIDREARSRSYDSAFFWLEDARLTNICRNATDPTVGLGLSEDNASFKCYMADTGLLVSQVFADRRSTPSEVYRDILFDRLSLNEGMLVENAVAQQLRANGRRLFFYSRYARGDSQRTMEIDFLIVRAHDDANLRARVSPVEVKSTKRYGTSLLDKFERTFGDRLGRSYVLHPRQVASSGQRTLLPLYFAFCL
>NZ_CP012069|946274:1016854|1005846_1006752_+|WP_050343813.1|DBSCAN-SWA
MSGFPSRTRYANLTDQELNMVFSTGHWERPDMGFEERLEACQELEMRLADRDGTIPRTVIGEDMPNRAYGYQQGGIIALNAHMLQDGAFKPAYDEQRMAQADPIPVLAPNWMIYDTVCHEHQHCVQHDEGRSQGSAYIEPSSEYSLYRIQPCEREAFEAGERGTSRALADVRKVTGVKDPNQEDYYAVNSTYTYKDALRQAQEHYQDPDIQQAVDTVVNDYRDGVSRSYQTSGERAVAQVLDSQMAQGREQGNEAQYQPGARQTVDDAIPLWEDEPSSGRDNSSLTWERPRENDRHQGMGM
>NZ_CP012069|946274:1016854|965411_966173_+|WP_050343760.1|protease|DBSCAN-SWA
MDEAMTDGRHIARYLIIAFAMTWTCWMARAALCASGVATVDSPAVLPLFLIGGFGPTVAALVVRPDARSLHGFARFVCGGSRTSIGWLFLLVVLGALSIAGNSSGLNAAIPAFAIPVIFLVTTLIGGGNEELGWRGVLQPELEGRLPYPVATLVTGVIWSVWHVPFWLTPGDSHLSFPFLLFALQAVLLSFWLAGLRRRGGSVLWCAVLHGAMNTLMSAFVLQLNAPFVIGMLAITALSIWMGMAAQRDDRRA
>NZ_CP012069|946274:1016854|946274_946871_-|WP_050343734.1|tRNA|DBSCAN-SWA
MPASAQPNDIRLICGLGNPGAEYERTRHNAGFVTIDILARRAHASFWKSAAGCMTCRIQLKGTDGDPCPVVLAKPQSYMNTSGGPLSKLMRELGVLAPEILVVHDEVDLSQGEVRVKCGGGLNAHNGLRSIADKLGTRDFARVRVGIGRPPGRMSVADYALRQLKGSFLEEFELSCERAADACEMCLERGVAFSVKNC
>NZ_CP012069|946274:1016854|964886_965408_+|WP_050344761.1|DBSCAN-SWA
MKIETAKRLYEYRRASGLSQEQVAAKIGVSRQAVSKWECAESSPDTDNLIALALLYGVTVDELLFADPERAIVATLERETDADDPEEGAESASVAEGAPAEAGEESAWQSPEHPEQDYVNISFSQGVHVRDSKGGEEVHVGWDGIHVDSDKEHVHLNFGGLAKMIREFRKDQE
>NZ_CP012069|946274:1016854|954704_955292_-|WP_050343745.1|DBSCAN-SWA
MGNEGKTEFQVKDLIVTALLAVCALAIYMVCAILSFSPYTMLAVSPLWALLAGITYFLVAARTKKSWALFVFCALTGVHGLYVPMIVCCLIAGVIAATLASKTSCTNERALTASYVVYMVLAAFGGMYVPFLFFSQQTLTQYSTQFGEDYMQLLSTIVSPAMAVAMLLVVALCAFLGSLIARKLLKKHFQKAGLV
>NZ_CP012069|946274:1016854|979703_981278_+|WP_050343781.1|DBSCAN-SWA
MSSKHETRDLLVRYAKARIPLITIKTDERRRAIEILTEVAEELGVKVYCHTKSKGIYDVTSMQTVCDGESVYEAFDFMREQMKKRSQLTFALSETGDISTETGDAQDLYDLVQSAVDASTTIIVITNKDVWGQLQQTGLVVVLDRPNEEEAYAVIRGLIDQYRGSIPIEWTDEEVREAASALAGVSQIEIENTIASLIANGHIGEDDLVEIRGSKDKLFSNISGLEKIQTSKSDAEVGGLAALQEWCKEKKELLTPEKRDALLKMGLKPPRGILLVGVPGCGKSLSAKSIASSWKLPLYRLDFATVQGSYVGQTERQLKEAFTMAEAVSPCVLWIDEIEKGLSGATASAGDGGVSTRMVGQFLFWLQECMKMVFVIATANNVSQLPPELLRRGRFDEIFFVDLPTTEERQSIMSLYMKKYLSLNFAGPLADELVELTEGFSGADLESTIRDLAYRKVANPQLSITADIIRKAFNNVVPLSQTSPEQIESIQNWGRERAVPASGKPIGSHPLQRSEGPRVREVLI
>NZ_CP012069|946274:1016854|978476_979247_+|WP_083443800.1|DBSCAN-SWA
MCGKKNRDSSNFCARCGASLKRLGVPASRADAAPERGGSVEAPAEQAFANVVPEVDSVPSKEVGEVAERQQDILVDAAPGGNDAPFEEVAEVAESQQEVIADVTPEGGGSVEVPAGQAFANVAPEGDDIPAKPEQATPEPNHIAMAEETGPSLPFEAISEHTEDAFAAVADEANDMDTLAPKGTAGDPSPADNGVGRMFASVDVGTFVSPRPVNNDVGKGNESVMEAYPTFAQGLPDWDLTPPSSMVIRHVRMAQK
>NZ_CP012069|946274:1016854|973053_974340_+|WP_083444084.1|DBSCAN-SWA
MSGFEPLRVPERDGAAEGFGFVPCEGGVCAARGIRATGVSAGFRHNPDRRDLALVVADRTCVCAGTFTKNRFCAAPVQVSRPRAASGHARAVVLNSGNANAATGEQGLEVARASARIVADALGCAAEEVLVASTGVIGVPLGLECFEMGVPACVGQLERSVAAAHHAARAVMTTDTHSKQAAYVGSLPAPGGGTVEVHVGGFAKGSGMIQPDMATMLSVLSTDAPLTPKAARVALGRAVSQSFNKVTVDSDTSTNDCCILFATGEAELEAIDEDSAAFPAICAALRATCEALARQIAADGEGSTRLVTVDVMGAATEADADAVARAVANSPLVKTAVFGHDANWGRVASAAGKCGVAFDQRKVDIDLLGVPVCRSGLAVAMDEDDMLKRFKESEVPIAIDLGMGSCSTRVWTCDLTHDYVTINGDYRT
>NZ_CP012069|946274:1016854|969725_970904_-|WP_050343768.1|DBSCAN-SWA
MNELELKYGTNPNQRPSRVFMRDGSDLPMTVLSGRPGYVNLLDALNSWQLVRELREATGQSAAASFKHVSPAGAAVGRPLSDVDRQMYFVDDEGELSPIACAYIRARGADRVSSYGDWAALSDCCDERTARYLKHEVSDGIIAPGYSDGALEILRSKKGGRYNVVLIDPDYRCAPIEQRDVFGVTFEQGHNDLAIDRSLLKDVVTANRDLPDTALTDMLISLVTLKYTQSNSVCYVRDGQAIGIGAGQQSRVHCTRLAGSKADAWFLRRHPKVLGLKFAEGIRRAERDNVIDVYISDEQDEVLAEGAWKQWFAERPEPLTREERTEWIAAQDGVTLGSDAFFPFGDNVERAHKSGVSYIVEPGGSIRDDDVIAAADRYGIAMCFTGTRLFHH
>NZ_CP012069|946274:1016854|992643_993348_+|WP_050343796.1|DBSCAN-SWA
MKVRILPSSNQHYVGNMQQSSGSLTWDSAGIDWTLMVRGAYGEPINIDDAIVRQLQIRGASLVNGPDGPVKLSDGRSIVLLRFNPMMGGINAYSYSNSHAHYAIFGCVYESESDMLTVYEPDSFAVTQCDVPGTVKVCIKKQWERQRHWLPFCSKDVFLGYSVSIEYDGKLSDGEDWGLQYEFSPIGSSGKSFCYPIVSKMVGAKLLVRASPGQEPPKIKSSKKGYVVEVTADL
>NZ_CP012069|946274:1016854|1010903_1011836_-|WP_083443802.1|DBSCAN-SWA
MPAPSPATTGPDSCARVEGDSDVRAAKERCRSRGSGRPGNRQLAAYRVLFEKRIGGAHGSEYVGLDFGHLRDLAAIDHMLRYTLLPMTLDIKHFAKVRLMREVTERADEDGYSIVADYLESLSERNRSIREKEMERLKRDRYSGGMARKYDNEKPVWVLIELLSFGGFINFYLFCADRWKDRRMRSEHYLFRQAQAVRNACAHSTDIINGFAPGETSTIRTPREVALALDEMGINRRARRAKMANPRVQQITMMAFAYREMVAGSHTREMCRSLVDALKHRAVEHADWYTNTDCVVSAYRFLAKVFDNWV
>NZ_CP012069|946274:1016854|1012025_1012412_-|WP_050343824.1|DBSCAN-SWA
MADNRGDWQFWCDGMHIVQGIRQRATNGFIGIDGSGELILFDNKGNEFDRAPIGEVEAKLKTWSGDSIKMNGTKYRLEFSPLKAALGRSFGALGAIAANAMRESSEDSRTPAQRRDEFAELVHKLQGR
>NZ_CP012069|946274:1016854|987093_990549_+|WP_050343793.1|DBSCAN-SWA
MSGQDSGNNVGKVVDGNSDEVVDGGQRFIQDDSAVLAIGLGGTGVDCLRTLKKRVYERLQSDNPGEVVPSYEHIKFLAVDSDADGMGKAADSSVYAPYKLNMDTEFFDVSCADNLSEIFGKNRVNLAKDPAYREWLQFDDINKVGTATDGAGGVRQIGRYLLVRRASEFVSTVRDMVTEAMEDANGNKRKVYVHVFSGLSGGTGSGTFLDACYLVREALRRAGANGNSVMGYLFLPDVNLADKAIPTNVRTYIEHNGYAAMQELDYCMGFGRNGDVWHQTYPRVGDVRWETPPVDLCHLVAGKTSKGVPLPKMYKHAMSVVADYVMDFLAKPAQVAFSLKSHLSNVQTIRDAERNEQDAGACYDYLVLGASCAVVPYGRIMTYLVSGFFQRLEGLGMRGRVPTQQEVERFQEGVGLTHDALLRELQRGVGVDPDYYGARPADAQKKSPNVEDHYMKLEAAAKGALAQNLSDLSRDVPGHVRSGLPTDGRAQAVMAKVVNAVLDAMVDPERGPWYASALLRSAKVTDLLAAARGIEAKAERERVQEEAQDEEGMPILDDFVRARDEFFNCSFRLKKRYDAFVEKTCELTRCRIRRDSYEALENLAGSLAAQIKRLADELTGPFEDAMGELIDIFDESWSYLKHFADGASTYEQPVVTMSQIAPVLDGELESCDVGKVTQELLDTLLDKRGRAALGPGGDRSILIYRVSDYFAETFKDWSQRSLTKYLEDKYGIHNNPKLLAKQVQDDLLKNMDKRAEVLFDTDGRYDLPDDGSALCYVTVPQTSPVVVNAADGFVKARGTGFKKRETSAADRVSFLRLKIGVPLWGYGALARCEAGYQPAPGRHLYERAVYVDGVSDSAEVEASRDWGNLPSPVPLSLSNSDIWVEKLNEALAADVIVPHKKGYYIRTLTDEFMGGIRTKHDAAKGLPIVDRLKVQNELQAMDSNRVYDPNVHLLSDMMRPQNIKAERTICADLLAKAPVLVEIVREELEKCREIAGYIEDLQPKVDHDLESFRNALFTGVIEFSNPVVQYVSGGLNGPIVLSDRTFGHGTIPLYQALLSFKDKSVLVPAMRKAIEAQTQSILTANQIPASVQGACDAVQRELDRGPNLIAIATAMFPREVGEVTNLLTDLTKQLTTFRLAYLIPGAKPNTN
>NZ_CP012069|946274:1016854|985027_987061_+|WP_050343791.1|DBSCAN-SWA
MGDRRRARGFARALRATALLLCATTLCLLSLLRASVAYAAGSDLKGDLTNRYNVVIVTDESGSMSRTDPDNLRGAAIARFVALLAQEGNRVGAVAFGEGIPLQSDLRDLTSVQLRQEFVQRMDTVALENWTNIGEGLRAAVGMLDGQRDASIPSIILLLSDGNTDMPSDEARQASLQTKAQAIEAARGAGYKIYTVSLNANGEADSNELRQVASATGGEFREVTSASDLQGVYDLYYSLVFSAKADQGSDVVIPDSGIVSGAFDVASIGVEEANVLITGTPTDYSFTRPDGTSVTRDQLAGSTFSTEALTAVKVREPLAGTWRYTVRGVPKDHVRVDIVRNTDVSVRLESSASGSKLSAGDSVDFTATILESGRPVKPEVYGSFSGELVIEGAGGSKQALALTAGEGGFALTVPFPDRGSFAVHATASGEGYELSTQTLSLNVGNSAPVPGETIQATVNLWPFIDNTATIDLTPGATDTEDGELSYEVESSAFMPDEYKIDGSKLVLSGYSLPEGSFTVRATDSDGASCTFDVHVKTVNIGLITCVVILGAILLALVVAGVLLRILLNKRFYGTCYVRPMDNESSEYQKETSLEGSRGRIKLALFGVETYGIDPQAYFQASGKDYVTFVSKVPVYSGGHMQRKVRVGGNGYEVPIAVDEKGQKGVVVRFKSELSRSR
>NZ_CP012069|946274:1016854|975287_976544_+|WP_050343774.1|DBSCAN-SWA
MYEFDTHADFIAGDERYLMHSYARLPVKFVRGSGCVLTDSEGRDYLDFLGGIGVVCLGHCHPRLVDALKGQAERLWQVGNYFHVENRSELAAALSRLLGATTDEEGHVTGSTGQTWRTFFANSGAEANEGAIKLARRWGERRLGGATGIVTAKRSFHGRTLATLAATGQDVFHKSFAPMPAGFMSAELNDLAALEEAIARPEASCGPVCAIMLECVQGEGGVWPADPEYLQGAARLCEERGLVLIVDEVQTGVFRCGAPFSYQLAGIVPDIVSMAKGIAGGFPMGAFSAHGEVADLLGPGDHGSTFGGNPLACAVGRATMETLVAEGIGEHVIEVGAQLAERLAALPHVTEVRGRGLMRGAQLDAPMARSLVEQGLRAGLVLNCVGDSTLRFLPPLVVTAGQVDAMAERLAKLMGQVA
>NZ_CP012069|946274:1016854|959257_961021_-|WP_050344758.1|DBSCAN-SWA
MGIVKTSGAADHRSSSVRQLLDHAGPYAKHLYASVVLAICGELFGMLPFAAVAIMVESLLDGTATTSGALALFAVALGGQLLRLALTFISTLMSHKATYRILKNMRSAIAEKMFRVPLGVLLETPAGDFKTLMVDTVSKLEDSMAHFMPEVTSNVVAPFCCIVVVFTLDWRMGLAALATIPLGLLCYAGMMRDYKSRSATYTSSQNAMNSTLVEYVGGIEVIKAFNQGTSSYGKFSEAVGSFHDSTLSWWRQSWFWSAMAQAVMPTTLLVTLPVGAWLYKEGSTSLPAFIVCIILPIGFIAPLMRVARYSEQFNMVRAHLATIQAFLEKAELKRPEQDIPLDDTAYRFEHVWFSYGDATVLKDVSFVVEPRTVCAIVGPSGSGKSTIAKLMAGFWDPQEGRVVFRGADIRDIPSRQMTGAISYVSQDNFLFNESIRENIRLGRPSATDEEVELAAKAACCHDFIVQLEDGYDTDAGDAGNRMSGGERQRITIARAILADAPVVILDEATAYADPENERLIQQALSELVRDKTLIVVAHRLSTIQGADQILVLDHGKLVGRGTQSELLASCPLYQRLWNDYVSVAELA
>NZ_CP012069|946274:1016854|948993_949545_-|WP_050343739.1|DBSCAN-SWA
MERYIAFDVETPNHLNDRMSSIGITVVQDGEVEDEYHTLVNPESHFDLFNTRLTGISAKTVQDAPTFPKAWEQIEPVMSSGLLVAHNAVFDLGVLRKCLDAYGIAWKARASYLCTVQMGRRLLPGMSHRLDVLCEYYGIDLDHHRAESDSRACAQILLRYLERGENIQRHVRTYSFEGKMSRQ
>NZ_CP012069|946274:1016854|962975_964592_+|WP_050343758.1|DBSCAN-SWA
MPSLSDQIASRRTFAIISHPDAGKTTLTEKLLLYTGSIQTAGSVKGKASARHAVSDWMDIEKERGISVTSSVLQFTYDGYCVNILDTPGHQDFSEDTYRTLMAADAAVMVIDGAKGVEAQTKKLFKVCTLRHIPIFTFVNKLDRDARDPFDLMEEIETVLGIGTYPMNWPIGSGRGFRGVFDRAARRVLAFEGDGHANATKRVDEVEAELGDPALDELIGEENHRNLGDDIELLDGADNEFDLEAVHTGKLTPVFFGSALTNFGVGPFLRDFLCLAPAPLAYMDRLTGEKVDPSRNDFSGFVFKIQANMDKNHRDRIAFVRICSGKFERGMDAQHVQGKRRIKLACGTAMMADDRATVDEAYAGDVVGLFDPGLFSIGDTVCAGRRQVEYPSIPTFAPEHFARITQVDTLKRKQFIKGMEELAQEGAVQIFRELGTGMESVIVGVVGVLQLDVLERRLRSEYGVEVMRQPLPYSEIRWIVNSPDDIDVARLNLSRDTCRVEDMRGGRLLLFTNEWNVDWAIERNPDLRLSEFGNVSLS
>NZ_CP012069|946274:1016854|1013661_1014885_+|WP_050343829.1|integrase|DBSCAN-SWA
MDVREFEEFVPCVIERMRADGCAEGPIGTAEWVLRWFAEFCREEEVGDVGDDAVADFCARRFGFDAGDAKLPTRTALRKPLLTAMGSCRTGSYCKTHQPGVVHEVPECMRGVYSLVITDFVGERRETGLRTKERKAWMAAKFLTFVAESGVGDIARLRMEDVDAFVGSLSGYAPATLRCLRGTLRELLDWMAGRGMVGLSGRMAFPVPKGSSRSTVLSYYTKDEVERIVAGIDASTRRGKPCLLVVALFALAGMRAGDAASLTLSDIDWDAGLIRIARQRTGEPLDVPMPDEVRYPPVDHMRNARPDSASGPDHLLVTVNAPHTRMRGAGTLGRIVGRRVEAAGVEPGRRRHGPHSLRHSLATNMLAADVPVSAISDVLGHGSARTTEACLTVDLAHARDLASGVPP
>NZ_CP012069|946274:1016854|983996_984833_+|WP_050343789.1|DBSCAN-SWA
MGLWGVVIILVFLFMIYKIILRGFKTGGSSGSLVLRLILVVFVLVLVPYVILMLVDAMSISMGIDIVRFADVGLEKWPAGKLIKGMLARGTPVSPLDVVVGTLQAICVAFVRALAPEVPIRDSLEEEHEYDLRNDRPRRSLRGWIGWVLLATLANSFVTVLISTIIGLIFSSPKEVLPLFGVIGVIVAVIPAFGLGFVFVKRILHARVLQGSEGPRFKYPNITLAFKMFMAIGQYACITAGLIVISQNAYLGACAAPFFLAGHEVLGMVKNAVKLDIE
>NZ_CP012069|946274:1016854|971584_971761_-|WP_172674436.1|DBSCAN-SWA
MIEYLWAAGDVVRHQLGGARDAAHRASGDLFRRDVGLLSQLRASGRQLLRRGRTRGDL
>NZ_CP012069|946274:1016854|983106_983955_+|WP_050343787.1|DBSCAN-SWA
MDLHIAVFDADANQSQNLVGLIGKLGLTWYGSPGHLVPTVVERSAYPDQGIDDLDVFVLSGVDSLVSHVPDVLFIASKLGGVDDAIRVVSGFLSDRHTTQIIFIVPSDVSVAHGHTVQHVGFLVCPISLDKLELALNRAVLTLFLERCQLGFDCPLCLRGTKATFYVLVSDIRYVESRGRTLHIHLRPHSKAMKKDDVSDGMASASGILDEVIPVTMSLKKFQTFVPDTFIRCHNSFLVNLSCVFRLSRDTITLRDGTCIPVSERKRQHVQQQLCRYGRVVA
>NZ_CP012069|946274:1016854|974392_975286_+|WP_050344763.1|DBSCAN-SWA
MRRRRPSDASQGKAEVLVEALPWINEWAGSTFVVKYGGSAMEDATLRAKVIEDVLLLKLMGVHVVLVHGGGKDISSLSDRLNLSVRFKDGLRVTDEDTMEVVQMVLVGKVNAELVQAINGYGNHAVGISGADGRTLRACQLDPELGRVGRVTEVNPDLALKVLDDGYIPVIAGVGFGEDGGPYNVNADFTASHIAQALGADKLFFLTDVDGLYADFDDKDSLIAGMGVGEARHLIDAGTLSKGMIPKVRSAIEAIEAGVGQVTILNGTVEHALLVETFTDEGIGTEISNDSRNPKEA
>NZ_CP012069|946274:1016854|1010290_1010740_-|WP_050343820.1|DBSCAN-SWA
MSAKGLKVIVRTMRDDKRERMPGLLSQAMAEELPPEGDDARLQGKTRRRQRQGGSRGVRTRRAVASTNRQGTCVRARRDGRGGAPEFRVLGTEGTARPRDARPTRHLRRSLPGSVTCPPGDSTATSRDCTRLVAPTTRSSSSSHALHID
>NZ_CP012069|946274:1016854|1012929_1013085_-|WP_157051394.1|DBSCAN-SWA
MEATGLGASRTSELLGDLVSDGILAAQGSNRWRTYMIADERAARRYLEEGD
>NZ_CP012069|946274:1016854|968326_969121_-|WP_050343766.1|transposase|DBSCAN-SWA
MARAVRDVGKLRPIDDLMFRVMAQSKAFCGELLRVLLQDPGLEVVECKPQSAVTNTRGRSAVLDALCELSDGRLVDVEVQRADKGDLQRRARYYASLVTADRTRPGTPFGDVPDVCVVLVCEFDPLRGGRPLYHVDRVVRETGESAENGLEELYVNALARDGSEVSALMRVLTEAEAYDEERFPETSRMKRRLRETEEGRKDMGSVIEEIRAECIAEGEERGKLEGKLETLVRLVRDGLVSVQDAATSVGVDADEIRRALAAEG
>NZ_CP012069|946274:1016854|962088_962586_+|WP_050343754.1|DBSCAN-SWA
MARGESGHLPYAGVGPLYVVAIIGVTVLGIALGQLGLIPCVGWPVPNAARIALGIALVVLGVAMWLAAFFGAGIDDGIRENQLVTTGVYAWVRNPIYVAFAMACTGAIVMADNVWLLALPLLFWAFLTLLMRHTEERWLLDLHGSVYRAYCERVNRCIPWLPRRR
>NZ_CP012069|946274:1016854|1008093_1009317_+|WP_050343816.1|DBSCAN-SWA
MRDTTYVRRVLMRRTCHLSSLFPDGRLISFGAFCGNPSQRSSVVLRGMRSALGKMGVVLLHTDLKLEAAAASLCSQLGVPMVRVGASGAAQRQAGGYDPLYGLDRFGVLRALGVADDHSAATHVGHYLTILDTLYRMSPGRFGCYAYSLGALLRFSSLPVVNLQTNVLQAFSSALSQDLVQSITMPGVQMDVYSRVSALAQRLSGTLCPALAQPGMSLPTPTTSLVALSTMRAVTSVYLPSGDVGTLDYLDAELDYLVRSHVPFMLVLSGIDVTGTDMRQRLISENAGCSYTVGVASSNPLSLMHDQQDVAALFAKLNRIVVFPCTTSQVAESVSSIFGTYDHVVRDSNAGVSRGHGQLFGTYSEGYVEHTVKEQNVRPEDLMGTDRGALVVWGGDRALVDHLDEWN
>NZ_CP012069|946274:1016854|970928_971585_-|WP_050343770.1|DBSCAN-SWA
MQDLCELLRNNPYPGRGIVVGKDWGGRHCAYYWIMGRSPNSRNRVFSLTADGIRTEAHDPALLKDASLIIYHPVRRMGDDLVVTNGDQTDTIVDTGDFFAACMAREFEPDDPNFTPRISAILHAGGSFELSILKRQAGASGRCQREFFCYEGADEGTGYLISTYQGDGDPLPSFVGEPVEVSLPTANELWVALNADNKVSLYANVGGTVKLYNKNLGD
>NZ_CP012069|946274:1016854|966255_967035_-|WP_050343762.1|DBSCAN-SWA
MDESKPAGRHYSVGQLAQMAGVSARTLRHYEDMGLLEPARAENGYRTYGPRDARRLSQILAMRACNLPLTTIRHLLRDSQASLRDTLESHLRTLRAQKKSLSDAMARTKAAIATIEGIENMDNEKRFEAIKAQGLKEFEDTYGTEARRRYGDEAIDAANERIMSLTRDEWDAKDLLEEAIKVQLRLAMASGDPTGDQAAELAHMHERWMRIHWGKSYDRKVHLALVRGYLGDPRFKNYYDTAAGNGGAEFLVKTMEANL
>NZ_CP012069|946274:1016854|1009318_1010149_+|WP_050343818.1|DBSCAN-SWA
MVKRCDRCKVAFDDRVSFCPNCGSPSVDDTRTLDELVAVGYRAFHGGRSAALPQEAPMPSSAPTAHIEEDEDERLRRGYEDFVLREQQGSTSVAGSKDEMGATSAQWLDSSLHPLVSSESAADQNCHESDADHVDRLMTGLGLGISPEASPGVVSSQEIVRESGTSIQPIAGQGAANPDYDLVFSDIRVEHERPKHELAEFVRDNASSRFFRDLFVPGTVLNRIGRALLLVVGIWLTIVLVVPLMVGMAINAFEALLPPLLCIGFLWYLMRGIFRR
>NZ_CP012069|946274:1016854|1002419_1005440_+|WP_050343809.1|DBSCAN-SWA
MYENLLLSAGGGIVDEALQCAQDDSAVLAIGLGGTGIDCLRTLKAKVHERLRPDNPGDAVPRYDHIKFLAVDSDAKGMKKAQRDGFGELDLDTEFLDISYPNSLSTLFATSRDGLAADPAYREWLQFDDLNKVGTATDGAGGVRQVGRFLLVRRASEFVSTVHDMVTEAMEDANDNKRKVYVHIFSGLGGGTGSGAFLDACYLVREALRRAGAAGNMLMGYLFLPDVNFARDYIPNVVRRCIGSNGYAAMQELDYCMGFGRNGDAWRQAYPGLGEVRCEAQPVDLCHLVAGKTSKGVSLPDAYDHAMSVVADYVTDILAKPEGICGSLTILLSKIRIFSAMERDRQDAGACYDYLVLGASCAVVPYGRIMTYLASGLFQRLEGLGMRGRVPTQQEVGQFQEDVGLTHDALLEELQRGVEVDPGHYDARPADAQKKSSNVEDHYMGLEAAAKGALDRNLADLSREVPGHVRTGLPPDGRAQAVMAKVVNAVLDAMVDPERGPWYASALVRSVKGTDLLAAAWGIEAEAVRECNHEAAQEQKGMPIWDDFARARGKFFVAPNIPFLLKGKYDAFVEATRELTLCRIRRDSYEALENLAGSLAAQIKRLADELTDPFERVMEGLIDTFDANRSYLKAFADGAGAYEQPIVTMSQIAPALDGELEKCDVGKVTQELLDTLLDEGGRAAWGPGGDDAPLARLVSRYFVGTFSDWSQRSLKEYLADRYNIHGNDQKLANKVQGDLLQTMGSRADVLFDTAVGYKLPVSSTLCYVTVPQGFPVVANAAAGYVAAQGAGYSVRMTSATDRVSFLRLKFGVPLWGYAGLARCEAAYTPAPGRHLYERAVHVEGVSDPAEVEASRDWGNLPSPTPRSKMGQGTDPEVRRRADEAAGVLDEALREGVVVRGAREYTIRTIADTFMRGVRDKYDAAARLPAADRLKVQDELRAMDSNRAYDPKKHILSDVMRPQNPKAERTICADLLAKAPVLVEIVRRELEKCREIARCIEDLEPKG
>NZ_CP012069|946274:1016854|998844_999285_+|WP_050343805.1|DBSCAN-SWA
MGLSDLFKRQHLILVMSFDCDDSGHISMSPISHIENCPSLIKPDGQVDTVNAFGIMKVTLFTVERARACKEFALWIGEMPKKGSSPIFYDCIKVKDLDFSVPGKIRGQFAHIDFRNVNDSSGHHSGMVFKVPVPDRSFSVKLNYDW
>NZ_CP012069|946274:1016854|976712_978446_+|WP_050343776.1|DBSCAN-SWA
MADRIIQTADLTTIENNLTSMRRAIEQVDDSVANVNRQMNGVEVRLDALASDFRDYVNNEMRRWELEHATTKLNNIRQQLAVKFGHYSEVRRTTTGILQATDLGIVRNATITKASEDLMLKCPEYWLAPCLVALAAWINDEKDIAKKALKEAIHRNDEKASLLFGLICRRANRQGPALEWVRRYLANQDPEGLGREAIIILDAYATGLFSADSEGAIAGQLNDWCDLLASRPGFLEEQTSRWKTALKDKRKPVDPTKYPYLRKYSHTWPILEDILEGAMAHQYILAYFKDIFAQQPSQDVVRKQLDDILTTLVSEFDDEELPLKREERLCELIIEHEGDTQEAQILADHEKTSMEEQRDFTQLLTDAAMYPDISRSSVSSQQFAVAYSREWICNGYNDMVAENRMKIPNDIEINIDSFNAVTSAGTDEENLVKAFDELVESERSAELDKTVLTPFEQNCHYAGIACIAFGLIALAAKLTFFGVLLCIAGIALVYKHYSQEKNINSHRDVINSNYDTKKENGTKLLKATIAEIVDFRIEFSQYDAGSQEVLDMLNELSPDEYVRTLTGVTRHIVSATH

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_050343734.1|946274_946871_-|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_050343736.1|947038_948226_-	ATP-binding protein	NA	NA	NA	NA
WP_050343739.1|948993_949545_-	3'-5' exonuclease	A0A2I6PEZ7	Staphylococcus_phage	8.1e-10	24.6
WP_050343741.1|949816_951178_-	ATP-binding protein	NA	NA	NA	NA
WP_050343743.1|951327_952695_-	replication-associated recombination protein A	G3MBE0	Bacillus_virus	1.1e-89	43.1
WP_050340583.1|952907_954524_+|transposase	transposase	NA	NA	NA	NA
WP_050343745.1|954704_955292_-	MptD family putative ECF transporter S component	NA	NA	NA	NA
WP_050343747.1|955319_956012_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_050343748.1|956008_957517_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.2e-10	25.8
WP_050343750.1|957524_959249_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	6.0e-27	39.9
WP_050344758.1|959257_961021_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.5e-36	26.5
WP_157051389.1|961067_961715_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_050343754.1|962088_962586_+	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_050343758.1|962975_964592_+	peptide chain release factor 3	A0A2K9L2P9	Tupanvirus	1.2e-13	34.3
WP_050344761.1|964886_965408_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_050343760.1|965411_966173_+|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_050343762.1|966255_967035_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_157051390.1|967417_967600_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_050343764.1|967955_968222_-	hypothetical protein	NA	NA	NA	NA
WP_050343766.1|968326_969121_-|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_050343768.1|969725_970904_-	phosphoribosylaminoimidazolecarboxamide formyltransferase	Q58MG4	Prochlorococcus_phage	1.1e-08	46.7
WP_050343770.1|970928_971585_-	inosine monophosphate cyclohydrolase	NA	NA	NA	NA
WP_172674436.1|971584_971761_-	hypothetical protein	NA	NA	NA	NA
WP_083444084.1|973053_974340_+	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	NA	NA	NA	NA
WP_050344763.1|974392_975286_+	acetylglutamate kinase	NA	NA	NA	NA
WP_050343774.1|975287_976544_+	aspartate aminotransferase family protein	A0A1V0SKB7	Klosneuvirus	2.7e-13	25.9
WP_050343776.1|976712_978446_+	hypothetical protein	NA	NA	NA	NA
WP_083443800.1|978476_979247_+	zinc ribbon domain-containing protein	NA	NA	NA	NA
WP_050343780.1|979243_979693_+	hypothetical protein	NA	NA	NA	NA
WP_050343781.1|979703_981278_+	AAA family ATPase	S5YL05	Mycobacterium_phage	1.3e-49	33.7
WP_050343783.1|981437_981929_+	hypothetical protein	NA	NA	NA	NA
WP_172674437.1|982173_982413_-	hypothetical protein	NA	NA	NA	NA
WP_050343787.1|983106_983955_+	LytTR family transcriptional regulator DNA-binding domain-containing protein	NA	NA	NA	NA
WP_050343789.1|983996_984833_+	hypothetical protein	NA	NA	NA	NA
WP_050343791.1|985027_987061_+	VWA domain-containing protein	NA	NA	NA	NA
WP_050343793.1|987093_990549_+	hypothetical protein	NA	NA	NA	NA
WP_050343795.1|990619_992635_+	hypothetical protein	NA	NA	NA	NA
WP_050343796.1|992643_993348_+	hypothetical protein	NA	NA	NA	NA
WP_050343798.1|993391_995011_+	hypothetical protein	NA	NA	NA	NA
WP_157051392.1|995043_997602_+	hypothetical protein	NA	NA	NA	NA
WP_050343803.1|997588_998743_+	hypothetical protein	NA	NA	NA	NA
WP_050343805.1|998844_999285_+	hypothetical protein	NA	NA	NA	NA
WP_050343806.1|999302_1002323_+	hypothetical protein	NA	NA	NA	NA
1001393:1001409	attL	NA	NA	NA	NA
WP_050343809.1|1002419_1005440_+	hypothetical protein	NA	NA	NA	NA
WP_050343811.1|1005535_1005850_+	hypothetical protein	NA	NA	NA	NA
WP_050343813.1|1005846_1006752_+	hypothetical protein	NA	NA	NA	NA
WP_157051393.1|1006757_1008092_+	type IV secretion system DNA-binding domain-containing protein	NA	NA	NA	NA
WP_050343816.1|1008093_1009317_+	hypothetical protein	NA	NA	NA	NA
WP_050343818.1|1009318_1010149_+	hypothetical protein	NA	NA	NA	NA
WP_050343820.1|1010290_1010740_-	hypothetical protein	NA	NA	NA	NA
WP_083443802.1|1010903_1011836_-	Abi family protein	NA	NA	NA	NA
WP_050343824.1|1012025_1012412_-	hypothetical protein	NA	NA	NA	NA
WP_157051394.1|1012929_1013085_-	hypothetical protein	NA	NA	NA	NA
WP_050343827.1|1013132_1013489_-	hypothetical protein	NA	NA	NA	NA
WP_050343829.1|1013661_1014885_+|integrase	tyrosine-type recombinase/integrase	A0A0M4RD74	Mycobacterium_phage	1.9e-06	26.9
WP_172674438.1|1015191_1015911_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_172674439.1|1016296_1016464_+	hypothetical protein	NA	NA	NA	NA
WP_172674440.1|1016542_1016854_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
1024890:1024906	attR	NA	NA	NA	NA

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NZ_CP012069|1873337:1899481|DBSCAN-SWA
CATGGCGAGGAAGATCAAGGCGAAGCTGATAACGCGGCTCCGCGAACAGGGCATGTCGAGGAGGCAGATAGCCAAGACGCGCCGCATGTCGATGGGCTCGGTCTGTGAGGTGTTCCCGGTCGCGGACGAGCGCGGCATCGGGTGGAAGGACATCGAGGGCAAATCCGACGAGGGCGCCTGCGTCCTCCTCTGTCCCGACAGGCACGTGAGGGGAAGCGTTTTCGAGGAGCCCGACTGGGGCTACGCGCACAAGGAGATGGCCAGGGTTGGCGCGAGCCTGCGCCTACCGCGCGACGGGCACGAGGACGGGCGCGGACGCACCGGCAAGGTGGCGATGGGCCACGCGAGGTTCTGTGAGAGGCGCGGCAAGCACGTCGCCGCCAACAACCTCACCAAGCGCATCGAGCACAAGGCCGGGCAGTCCTGCGAGGTCGATTGGTCCGGGCCGACTCTCGGGAGGGGCCTTGTCGATCCCACCACGGGCGAGGTCTCCAAGATCCACCTCTTCGTGGGCGTGCTGCCCTTCAGCCAGAGGGCCTACCTCGGGCCGACGCTAGACATGAGGGAGCGCACCTGGCTCAGGTGTCACGTCCACACGTGCGAGTACTGGGGAGGCGTCCCCGAGCGCACGGTCTGCGACAACCTCAAGACTGGCGTCGTGAGGCACCCACGCGAGGGCGAGGTCGTGCCCGACGACGCCTACGAGGCGCCCGGAGAGCACCACGTGACCGCGATCATGCCCGCACAGGTGAGGAAGCCCAAGCAGAAGGCGTCTGCCGAGGGCACGGTGAGAGACGCGGCCACCTGGGTAATAGCGCAGCCGCACGACGCGACGCTCGCCGACTTCGGGCAAGCCAAGGCAGCGGTTCGCGAAAAGCTCGACGAGCGCGACGCCCACCCGTTCCAGAAGAGGCAGGGCAGCCGCGACCCGGTCTTCGCCGAGGCCGAGGCCGCCGAGCTCAGTCCCCTTCCCGACGTCCGCTACGATGTCGCCGAATGGGTCCACGGCCGCTCGGTCGCCCTCGACTCCCGCGTCGCCCACGAGCGCAACCGCTACTCCGTTCCCCACCGCTACGTCGGTCGGAAGGTGGACCTGCGCGTAGGCGAGTCGACAGTCTCAATCTACCACGCCGGAGAGCGCATAGCGACGCACAGCCTCCTGCCCGAGTACGCGGGGAACGGATACTCCACCGACAGGTCCCACATGCCGGAGGCCTTTCTGAAACCGGAATGGGACGACGCGCGCATCAGGGGCTGGGCCAAGAGGATCGGACCCTCCTGCTTCGAGGTCATCGGCAGGATCTTCGCGCGCGTCAAGGTCAAGGAGCAGGCCTACAACCCGGCGCTCTCCGTCCCCGACCTGTCGAAGAAGTATGGAGACGAGAGGCTCGAGGTCGCCTGCGCCTACGCGCTGCCTAAGCTCACCTCGCCCAGGTACAAGCACCTGAAGGCGATCCTGGACGCGAACCTCGACCAGGAGGGGCCGGCCGAGGACGGCCCCGGCGAGACGCGGGACGCGCCCAAGGGCCACGTGCGCGGCGCGGACTACTACAGAGACTAGTGAGGAAGCCATGATAGACGACGAGACCAGGCGCAAGCTCCGCGAGACGAGCATGTCCGAGATGGTCGACGCCCTCGACCTGCAGGAAGGGGATCGCACCATCATGTCGGTGCCCTTCGACGAGCGCGTGAGGATGGTGGTGGACCACGCCTGGGAGGCCAAGCGCGCCTCGAGCGCGAGGCGGCTCACTCAGAGGGCCAGGCTGCGCTTCCCGGACGCCGAGCCCGGCGAGATGATCTACGACGGCCGCGGCATCGACGGCGTGCTCATACGCGAGGCGATGGCCTGCCAGTTCATGTCGCGGGCCGCCAACGTGGTGATCGAGGGCTGCACTGGAACGGGCAATTATGCTGAGAAACGGATTATGTCGGGGAACGGGCTGCCGCCGCAGGTCATTTGCTCGCGGCGGCCGCGTCCCCTTGCATAGTCGAAGAGTCCCCCTGGCGTCGCGTCACCTGCTTTTTCGACAATGATAGGAGGACTTATGGCAGATCACACCAACTTGGAGGCCCTGATCTCCGATACCCTGGTCGAGATGGGGAGGCTCGGCTATTCCGAGAACACCATGACCGGGCTCGGGAGGATGTTCGCGGCGCTCTCGAGGTACGCCGTCTCGCAGGGACGCAAAGAGTCCGGCGAAGAGCTCGCGATTCGGTTCCCCGATGCGAAGTTCGGCGTCGAACTCACCCAGCCCTGCCAGGCAAACCCCGGCGGGGGCCACCCCAGGGCCTGGCTACGGGCGATGCGCGTTCTGCTCGAGATGGGAGAATGCGGCCGCGTCTGCAAGCGCATGCCCGGCGATCTCGCCTGAGCCGAGCTGCCTGCGGAATCGCGGTCGCTGCCGGGCCCGTCCGACGATGCCAGCCGGCGGGCTGGGCACCCCGGGTCGACCGCCTGCTCGCGCAACGGCCGCATCAAGCACTTCTTGATCTTTCTGGCAGGCAACGGCGGGACCGACGCCTCGTGCATTACCGAGAGCTCGGCGCACGACTACATCCTCACGAAGTCGTCTAACCACGCCAAGTCGGTGAGGGCGATCCCCGCCGCGCCCCGGTGCCTCCCGCGCCACCCGCGCCCGGGGGCATGGCGGGACGCGACCTCTCGCCGAGCGTGCCGAATCCCAAGCCCTGCTATGCCCCCGAGCTTCCCTCCACCTGGACGGCGGACGAGGTGTCGAGGCTGATGAACGGCATCGATCGCGGCAATCCCACGGGGAAGCGCGACTACGCCATGCCGCTCATGGTCGCGAGGCTGGGGCCTCGGGCCTCAGACATAAAGTCGACGCCCGTCTCCGACGTCGGCTGGTCGGCGAGGACGATATCGATCACACGGCACAAGACTGGCGTGGCGCCGGGGCTACCGCCGCCCGGCGACATCGGCTGGGCGGTGATCGACTACCTGCGGGAAGGGCGCCCGAAGGCTGCCACGTGCCCGCGGCCGCTCGTTCGCCAGGTGGCGCCCTTCGACGCGTTCGGCGCAACCGCCAACCTCACCGACATACCCATAGGGCGTGCGCGCGGCGCCGGCATCAGGGCCCCGCGCGACCACAAGACGCCCCGCCCCCTGCGCCATGCGTTGGCCAGGCGGCTCCCGGGGCAGGAGGTCCCGACAGGGGACATATCCCGCACGCTCGGGCACGTCGACAGGCGCACCACCAGCACCTGCCCCCGCACGGGCGTCGACTCCCCGTCCGCATGCGCGCCCGGCCCGGCGCCGGTCGCATGGCCTTCGCCAAGATCACGTCCGCCTATGTCGCGGAGAGGAGGGCGGTGGGCCCCAGGTGCGAGAGGGACGACAGGGTCATGGCGAGGATCGCCGCCTCGCGCGGCGAGCTCGGCTGCCCCGAGGACGAGTTGCCGAGGGCGCTCGTCGAGGCCCGGGCCGCGAGGCGCCCCGGGGAGTCGGAGACGACCGGGCCGTGCCGGGCCGGACGGGCGCGCGGGCCCGCCGACCGCATGATGCGCGCAGGCTACGACGCCTACGTCGCACCCGGGAGGCGGGGCCGTGCCGACCGCGGCGCCCACGGGCCGCACATCTTCACAGACGCCGAGCTCGCATCGCCGTCCCCCGCAGCCGGGGCTATCGCGGGCGGCGATCCGGCCAGCCGGCGCGCGCAGGCCGCGAGGCCGCCCGGACTGCCCTGTTCCTCCGGCCTCCGATGCGGGGAGGCATGCTCGCTGGCCAAGGGCGACGTCGCCCCGGAGGCGGGCATCCCGGCGATCCGCCACGCCAAGAACGGCAAGGGCCGGCTCGTCCCACCGCGTCCCTCCATGACCCATATGCTTCGCATATTCCACGACACGGCCGCTTTGCGGCATCCCCAATACGGGGGTCATGGGCTGTTCTGGTCCCTGCCCGAGGGCAGGCCGACGGCCACGGGCTTCGCGTGCCGTTTCTTCAGGAAGGCGCTGTGGGCGGCGGGCATATCGCATGGTGGCCGGGGCAGGGGGCCGCGCGTCCGTGACCTCCGCCTCGCGTTCGCTTGCCATAGGCTGAGGAACTGGGTCAGGGAAGGGGCCGACGCCGATGCCATGATGCCGCCGCTCGCCGCCCACGTGGGCCACGCCGACATCCGCCGCGCAGAATACTACCTCCGCCCCGCCGCGGGGACCTGTCCGGGCATGGTCGCGCGGGCCGGGCGCGAGTGCGGATGGGTGGTGCCGTCATGACCGACGCCGACCTCGCATGCCACGCCACCGACTGTCTGGGACGCCACCCGGCCGGCGCGACCCCGGTCCCAACACGATAGCCTCGTACCGCGACGCGTCCGGGCCGCCCGTCGACTACTTCGGCGATCATGGCAAGGAGCCGGAGTCGATGTCGACGCCCGATCCGGGCGGACACGCGGTCAGGGGGTCCCCGGGTGGCCTGCGGCGCGCGGAAATTCCGACAGCACGGCCGACCGGCGCCTTTGCGCGACAGAGGCGTTCGTAGGATACGTGAAGGGAGAGGACCCCGCCCGGCTCCCGCAGTACCAGCAGGTCCTCGCCATGAGGCAGCGGAAGGGGAAGCCTGGCGCGATGGCCGCGCCCGGCAGGGACGGGCTTGCCGCCATCCTCAGGGACCCTGGGATGTCGACCCCCGGGGGACGCCGCGACACGGCGCCGCCCGCCGTGCCGTGCGACGGCGCCGCGCGCGTGTCCGAGCTCTGCGGGATCACCCCTCGAGACCTGAGGTCAGGCGACCCCGCCGTCGTGACGCCGCGCGGCAGGGGCCGCAAGGCCGGGACCGTGCCGCTGATGCATGCGACTGCCGGCTTGCCAAGGGGATGCGTATCGGAGGCCTATCCCGGCCTCGGTCCCAGGGACCTCGACAAACCGCTCTTCCCGAACCCAAGAGGCGACCATCCGGCCAGGGCCGGTGTCGCCGACATCCTAGCCAGGCATGCGGACGGGGCGAGGAAGTCCGGTGCCGACATCCCCGAGGGTGTGTCGCCCCACTCGTTCCGGCATCAGAGGGCGACCGGCCTGCCGGGGTCGGGGCGCGAGCCTCGTCCACATGAGGGATCTTCTCGGCCACAGGAGCGTCACGACCACCGAGATCTACGCGACCGCGGGCACGGCGAGGAAGCGCGAACTGCCGGGGAGGGCCGCAACGGCACCCAGGGTCGGGGAATACCCCGACCGGACAGCCGACAAAGACCTCATGGCCTGGCCCAAGGCCCTCTGCTGATATGGGGTTATGCAAAGGGACGCGGCTGCCGCGAGCGAATGACCTGCGGCGGCAGCCCGTTCCCCGACATAATCCGTTTCTCAGCATAATTCCCGTTATGGAAAACTTTCCATAACGGGAAGACCCACCTGGCCCAGGCGTACGGTCGCGAGTGCTGTGTGAGAGGACCGAGGACGTACTACATGAAGGCCAGCGAGCCCGGGGACAGGTTCCAGAGGGCGGCGGAGCGCGGGAGCGCCCAGCGCGCGGTGGCGACGCTGGCGAGGCCGTCCTGCCTGATCGTGGACGAGGTCGGGAGGTGCGTGTTCGACAGGGCGTGCACCGACCTCTTCTTCGACGCGGTCGACCGTCGCTACGAGAAGGAGGGGCCCAACACCATGATCCTCACGAGCAACATGGCGCCGAGCTCCTGGGACGAGTTCCTCGCGGGGGACGAGGCCCTGCTCTGTGCGCTCGACAGGGCATTCGACAAGGCATCGGTCTTCATGATGCGCGGCCCGAGCTACCGCGGCCGCGGGCTCGACACCTACTCGGTCGAGGCGGTGCCGCAGGCGACGAAGGTCAGGAGGATGCAGCCCAAGGGAGTGTAGCCACTACATAAGTTAGGCAACCGGCTGCCGGCGCATTGGCCAGAATCGGCTGACTGGGATTGGCGATTGTCGCCTGACTGGATGTGGCTAAACTCTTCCGGCGCTAACAAGGGTCATCGTCACGCCCCTGCGGCCCATCTCCCTCCGGGCCCACTCGTGGTCGATCTCCGCCTTGCTGGCGTCGGAGCGGTCCTGAGGCGGGCAGGGCCTGGCACGGATGGCCTCGTCCCCCATCTCGTCGGACAGCGGCCACTCGAGGCGCCGCGTCGCCGCCTTACGCTGCACCTCCTGCACCGTCGTCTTCGAGCATCCCACGGAGCCGGCTATGCTCCGCTGGCTTATCCCCAGGGCCGTGAGCCTGAGGATCTCCCCGTGCCTGATCATGTCTTCCCCTCTCTCGGGAGACGGGGCGACCCAGTGCGCCCCACTGGGTCAATCATGGTCGGTGATGCGTGCAGCGGCGGTCGGCGGAGCCTGGAACTGCGGTCAGTGGGAGATGGAATGCCGGTCGCTAGGGCCTGCTGTACGCAGACGAGGAGGGGCTCATCCTTATTGCCACACGCACGGGAAGCCACAGCGAGCTGCTGGGGCCATGAACGTCGCCAGCGTTCATAACGAGGCCTCGTTATGCCCTACCGTCACAGGACGTAGCGCCGAGGCGCAGCGCAACGAGCCCGAGCGGTCGCGACGAAGAGCGAGGTCTACTCGCATCCCCGTGGAGTAGCGCACCGGTGATGCGTGGAATCAATCATGCACCGATTGGCGCATAATATTCATTACTTGGGCGCGAGTCGGTCGAGCCGGGAGGCTTCGAGGAGGCCACGGGTCCCGCCGACGCGTCGCCACGCGCCGGCGTCCGTGCCGGCACGAATCCCGCGCGGCCGCCCTCGCACGCGCCGTGGAGCGGCTGCGGGAAGTCGGCCGCCCGCTCGGCCATCTCGCCGTGGTCGCTTCCCCCAGGCATGCAAGTCCCCGGCTCACCGTCCTTGGGCGCCGGCGCGCATGTCGTCGTGGCTCACGAGTGGCTGTCGGTTCCGAAATATGCACGATAAATGGCTATGGGGCTATAATCACCCGACGCTAACACCTCCCGTTGATCGTGGCACCCCGGTGCCGTCCTGCTGCGACGAAACCATTCCGGCTCACTCACTTCACGGGAGGTCCTCTTGGGACCCCGGCCCAGAAATAAGTTCCGCTCCCTCAGCTCGGGTCATATCGTCTAGAGAGTGTCATACGCAGTCGTCTACGAATTAAGCAGTTGGGAAACTTGGTCCATGCCACAGCACCTATGGTGAGCCAAGTGGTTGCGACACTTCCGGAGGAGAAATATCCTATCCCGCAGGCCCTTCTCCTTCACATCAAGTACCCGTACCCCATCTTGGTCACAGTTCATGAGGTAGACGAGTGTTCCTAGTTCGACATCCTCCAAGGAGGTCAGCTTATCCCCATGTTGCTCAATTCGACCTCCGTCTATTAGAGGCGAGATGGAATCACTGAGCTTCTCGACAATCAGCAGCCTTTCCCTCTCAATCATCGGAAAAAGAACCTCCAGTTGGGCGGCCCAGATCCTCTCGTCGATTGTTGCCTTGTCGCCTCGTCTTGCTACGTTCAAAACATGTCCGAAGCTTCCATGTCCGCGTGAATCAAATATGCCTGAATCAACCATCGTCGTTATCGCAACGTAGGCATCTTCTTTCCTTAGATCATGGCTCCAGACAAGCTCATGTGCGACCTCCACATCAGACCCGCAAAGGCTTGTCATCAACGCAGCAACATAACGCTTCCATACCATCTTATAGGAGTCGAATTCCTGAGAATTAAGAGTAAGACCATTGAACAACTGGACACTGTACTCATCCACACACTCTGCATAGTCTATGATTGTGAGGTTTTGTGGAACACTGGTCTCACTGGTTCGGTCCTCAATCACGAACAATCCCTCATCAAGTGTAGAGATGTTCCATCCAGCACAGAATCGTTCCCACACCTGGGCGTCATCCACTCCCAAGCCCTTTATCCAAACAATTTTGTTGCGGAGAACACCTCTTCTGAGGAGATACCCCTGTCCCGACCCTCTGCTAGAGCGATAGTGTAGCGAGTCATCGCGCAAACCGAACTTATCTACCAGATACTTTCCTGGTTCATATTCACCTGGCAGATCTTCCTCAGCATCCAAAAAGGTGATAGCAAGACTCTCGGTCCCAGACGTCGACTGCAGCTCCTCGCGCAGCATGTCTCTCATCTTGTGTCGCCAAGGAAGGTCCTGCGGTACCTTCAAGACGACGGACCGCTTGCCTTGAAGCGACGATACGGTCTTCTTGACAACTTCGTATGGTCCGACAACACGCTGCCACCAGAATTCTGGCCAATCCTCTTCTGTGGGACTATCCCTCCTAGGCATCATTGTTAGCGATGTCATCGAGGATCATATCTGCATCCTTGCCAATGATACTGAGAAAAGCATGTCTACGGAGTCTGTACCTCTGTGTGTCTTGATCAGGCTTGGCAAGTATGTACATGTCTACCATCTCGTCCATCAGGTTTCCGAAGGAGGAAGCGCTCTCATCTGCAAGTGTCTTGATATCCCACTCATCTGCGGTGTGTTTGACCTCAGTGGGCGAGTATCCGGCCAATGTGCCTTCCCCACCGCTCTCTTCCGCCTCATAATATAGAAGCGCGATGCAGCGCGCGATCATAAAATATCGGGGGTCAAGTTCGAGGGATAGCCTGAATTTTTCCTTAATACTGTTATTAAGGTCGGTCCTGCTCATGATTGCCCCGAGCTGTTCTTTCGTAAGTGAATAAGGAGGATTTCCATCTTGGGCACGATAGTATTCGGAGTACTGACTGGACATTGTCTCCACAAGAATGTTCCCGAAGAACTGGAGAATGCCGGGGTAATAGTTCGTGCTCGTAAGGATGGTCTCCAAGTGTGGATACCTGTCCACCTGGAACCCAAGGAACATAAGTGGACGGGAGATTAACCTCAGCGCCTCTGCGGGAGAAAGAGGCCTGATACACAAAGGTGATCCGAGCTGACCAAAAATACCATTCTTGGTAGTGGCGTTCTTCGCTCGGGAGACGTTATGGAGGCCAGCTAAGACAAATTTGAACTTGTTTTCCGACTCGCGTCGTAGCTCGACAAGCGGTTGCAAGGGTAGATAGCCTTCGGAGCTGATAGAAGCAAGATAATTGTCTGCCTCGTCAATTAGAAGGAGGACTTTAGATACGGCTCTATCCGCCAAGATCTCTCTTATTCGGTCGCACAAATCTACGATTGAATGAACGCCGTTGAAGTCAAGCCCCGCTCTGGATGCGGCAGAGGCAAGGGTGCTGATAAGATCTTGTTCAGTGTCGCACTGAAGAATACTCACGTACACCGCATACTCACCCTTATCGGGCTTGTTACAGAGGCTTCGCGCTCTCTGGAGGAGCGCCGTCTTACCGAGCTGTCTACCGCCGTAGACCACTCCCGCACCACTAGGATTCGTTATTGCCCTGAGCTCCTCCTCCCTACCACAGAACATCTCGTCCGCTGTGGCGCCGCCATCCCGAACAAATGGTTGATAACTAGTGAAGGGCAGGGTACACTTGAGCATCACCGAAAGTCTTGTCGCACTTTCATTCAAAGCGAGAAAAAGAATCAAGACCTGATCGATTACGAGAAAGGAAGGCATTGATGCCTGCCGCTTGTGATACAGCTCCGCAAGGGTACGCCTATCCGAGAGACTGATCGAATAATTTACGAGAACAAAGGAGCAATTGCTGAGACCCGAATCAACGACAGCCCTAATGATATCCTGCGGCGTCTGGTTACCATAAAGTACTAGAACTTCGATCTTCTTGTTCATCTGAGTACCAAACGCCGAAATCGGGTGATCGTATGACTCACGATCACGCGAAACGGGCCGGACTTCGAGCCTATATATCTCGCGACCGATAGAATCAGGCTTAGCAACGCCTTTGATGCTAAATCCCAATCCCTTGAATAGCTCACCGATGTTCTGGGACCAATCCTTCACCTGCCGTTTCTGACTCACGGGCCAATTCTGCACCAGTGACTCACTGTTCTTCTTCTGCCGCTCGGTCCAACTCTTTGGATACCGCTTTCTGGTAAAGTCGATGCCGTAACTAGCGAGGGGGCGGCCCTTGTACTTTCGGCAAACGTCAAATATTGTCTGATAGAACTCGCCCGAAATGAAACGGGCAAAGTCATCCTGCTCACTCATCCCAGATCTGAGCTTTTCTGTAAGTTGACGCTCACCCGATTCAAACCGGTTGAGATACTCCTCGACAACGGTGAGGTTCTTGTCTTCTCTCAGTAGCTTTTCCGCCTCATCGAGCAAGGTGGAATCGCCCCCAGATATTGAGCCCCTGCACGACGCGAGCCTTTCTTCGAGCAAAAAAGAGTGATCTGCAGAGAGGTCATCAACCTGCTTAAAAAGAGCCCTGAGAAACTCCCTCCAACAGCCATACTCCTTGACCGAGTAAAAGAGATTCTTGAATTCTCTCGCGTAAGAGGCAAGGTCCTCCTTCTGCACCTCATTGATTCGGTTGTACGTGAAGGCAATCTCTAATTGGTCGTTGAACTTCGCCAGCTCTGCCTCTGCAGACTGTAATGCAATTGTCTTTATGTCCTTGCTCGGCTCGACAGCTTCAGCCTTATCAACCATCTTACTAATTGCAAAAAGTTGACTTAGATTGTCGAACATCGGGGAATCATCGTCACCAATTTGGTTTTTCACGTCAGTAAAGGATGGTTTATCGGCTATGTAGTGCCTCAGAACCGCTTTCCACGGCTCGCAATGGCTCACATTGCAAAGAGATCCCTCGACGACAGGCAACCCATCAACACCGGTTGGCAACAGGCCCGTTCGTAGGAAATCGCTGAAGGTTAGAACTCGACCGCAGCTACCGCTAAGTCTAGTTTTTATTTCACGGACCGCTGTGTGTAGTGCAGTACCGCCACCTTGCTGACCGATAAACAAGTTCATGGATATGATTTCGTCGGATAGGGTGAGAAGGCTGTCCCTTATTTCACGGATCTCCTCGATTTCACTCTCATTAACACTGCCTCTTACATGCTCAAGCCATTCTTCCATCAGCCCAAGTCGGTCATAGATTTCGTCGGAGGCTTTGCGTCGAGACTCCATGGCCAGTCTTCGAGGACCCTTGTTCCCTTTGGCGTTTATCGCCTTGCTCCATGCGTTATCAATCAGGCTCTCGATTAATCTGTCAGAAAGCTTTCCATCCACGCAGTACGCTTCAAAAACCTTTTCGACAAGAAAAGCTTTATCCTCACGTCCACGAACGATTATATCCAAACAGGGAGACAGATCACTATTACTACCAAAGCATATCTGAGAGAACACTGGCAGATGACTCATCTTGGCGTTAAATTTCGGAGGCCTAAGCAGCGTTTTCGCCTTAGCCCTGATTCTATCCATAGCTCTGCGCCTCTCAACGTCACCACCAATCCCAGCAAGGACGCTGGACGTAAAGCCACCCTCTGGAAGAATGTCACAAACATTTATTAGCTCACTAAACAGAGGCTTTGCCCTCGAAAACGAGGGAAAAACCGTATCAAATGAGTTGAGGTAACTCTCACAGGTCTTGTACAGTTCATGGTCATAGCTGTGCTTTGGAGCAAGCAATGCCAAGCAATACGCGGCTAGCACAAACCCTTCATTTTCCTTGCTATACGTTGGAAAAGTAGATTTTATGTTAGCTCCTGTGTATTCTTCGCATTCCAAAGGCGAGTTGACTGCCAGAGAGACTTGCTCATAGAGCGCTGAGGAGTGGCCGAATTTTACCTGTCCATGTACGCTTTTTAGAAGCGTCAAAGCAGTTTCAAGGTTAACAAGGCTATCAGCACCATCATCTGATGGAATTTCTTCCATTAACCTCGTGGCGAATTTGGTAACGATTTCGTCGCTAATTTCCAAGTTTCCTCTAAGGATGCTTTCTGCCATTGCACTTAGAGATATCCTCTCCGTAGAAGGATCAGAACTGTTGTCCCTCCGACTGCCATCGGAGTCGTCGGCACGTTGCTCGATCTGCGCAACACCCGCAGACAGCTGTTCATTCCCATGAGCCTCTTTGGCAGAAATTGTCTGATCAGTTTCTGAATTGATACTTCCACTTTCTTCGACAGACAAGTTCGGAGTACCTTTATCGTTCGATAACAACCTCTCTTGAGAACTTGCTGACTCGTTCTTTGCAACCTCCTGAATTCCGCTGTCCGTAATTACAAACAGATGAGTGACTCCACAAGCAAAGCGCTCTTCGTCTGATGGAACATCGAGAACAAAGGCATTTGTTGCACCCTCGGGAACAGAGGCTGTCCTCCTCGCAAGAATTCCCTCTACCCTAGAACCCCCAACCTCACACTGTATGACATAGTGATTGCCATCCCAGTAGCATCCTTGAAGCCGCCTGTACAGCATCAACTTGTGTCCGGAACCCATAGATGACTCCAGAAATGAGAGAAGTACATCATTCTGCGCCAACATCTCCATGGAAGACGCCGAGGGATCACAGCCAGGTATGTTTCTCTTCGCATCTACATAGGGAAAAAACCAAGTCGACCGTGAGTGGCTGTTCATCATATTGATAACAGAGTCTTTCCTTGCAAGCTGACAGCCATCTTCACTCAGAACAAAAGCATCCGAGTTCTCAAATTCGAAGCCTGCCTTCTCAATGATTCCTTTTTGGGCTAGGTACGACGCAGAAAGTGTGACCGCATCGGGCGACAGCGATTCGTCTTTTCCGAAAACTACAACTGCAAGCCTCTGCAATGCCTCTATGGTCATACAGCGAAAGCGCGCCAGCGCGGCAAATGTAAGAGCAACGACAAGATTGGGCGATTTCAAAAGAAGTTTCTTGAAAGAACTCGAGCCAGTCCGCTTCGGTCGATTCAGATGGGGATAGGGCGCATGGAACTCTTCCTTTACAGTGGAGACCGCGTCTTGCTCTGCATGCCCATTTGTCTCAGTAGGCACTACACTTGCACCGTCTCGTATGTTTCCTTTTTTCCCCTCAAGCCCCGCGTCACAATACTCACCGAACCGGTATATTCTTAGCGCTACTCCTTGCTGCACTCTCGTCGGATAGCTCTGCGTAATCATGTCAAGCAAATCGATCCCCACAGTAGTCGACAAGTTATCGCACTCCAGTGCTTGGACAAATACTCTCTGCGGCTTGTATTGATCATCAATATCACCAAGGTCTTCAAGTTCCCCTGCGCTCAATGATCCCTAGTTCTTTCTGATTGTAGAACTACCGCCTGATCAAACCAAAGAAAATCGAGAAAATCGCAGGTCGAGGCCCCAAGGGGCCTCTCTTGTGCTATATTATATGTAGTGCTACTTACTACTTCCTGTGTGGCACGGGAGGCGACCGGGATGCCGTTCATAAAGGTGCAGAAGCTGGTCAGGGACGAGTCCGGCGCAATCAGGAGCGGGTCCGCCGCCGTGGTCGACACGTCGTACGTGCGCGGCGCCAAGTACCACTCGGCGCAGGCGGTGCGCGAGAGGCTGGGCAAGGTCGTCTGGCTCGCGGACGACAGGCGCTCGGGCGTGTTCGCGTCACCGACGCGCGGCCTGGTGGAGTACGACGCGGACGCCGACGGATTCGCGCCGGTGGCCAAGGGCGACGAGCGGCTGGCGAACACGGGCGCGTTCCCCGAGCCGCCGCGGCACCTGGAGCTCGGCCCCGAGCACCTGCTGCTGTCGTTCCTGGGCGCCGATGGGGTCGCGGGGTGCCTCAGGGAGGCGCTCCCCGACGACCGGTCCTACCAGCGCGCCCTCGCCCACGTCACGCACGGCGTGGTGCGGGACGGGAGCCGCGAGACCTGCGACAACATGGTGGCCAGGTCCTTCGCGGCTCTGGCGCTGCCGGGCGTGCCGCCCGCGTCGCTGAGATCGGACACGGCGTTCTTCTCGGCGATGGGCGCCGACGGGGCGAAGGTCGCGTTCTTCAGGGCGTTCGCCAGGCTCATGAGGAGGACGAAGCCCGGCTTCGGCCGCGCATGCTACGTGGACTCCACCCCGCTCCCGAACGACGCGGTCGACAACCCGCTCAACGCCCTCTGCAGCCACGGGCTGAGGGGCGCGGCGGTCCAGATGCGCCTCGCGCTCGTGCTCGACGAGACGACGGGGCTGCCCGTCTGGTACGAGGTCGTGCCCGGCAACGTACTTGACCTCTCGACCATAAAGACCGTGATGGGCGACGTCCTCGCCACGCTCGGCATCGAGGTCGTAACCGCGGTCCTCGACGCGGGCTACGCGTCGCGCGAGCTGCTCGAGGCCTTCTCCGAGGGCGAGAGGGACGTGCTGGTCAGGATGCCGGCGAGGAGGGGGTACCCGTACCGCGAGCTCTGGCGGGGCGTCCGCTCTCTGATCGGCAAGGGCAAGTACGCGATCACGCGCTCCGGCCACCTCTACTTCGCCAGGAGGCGCGACGTCGAGGTGCAGGGCGTGAGGCTGCACTGCTACGTCTACGTGGACCAGACCAACGCCACGCCGCGCTTCGCCAGGTGGCTGGACAAGAACCAGGAGAGGTTCGACGGGATGTCGCTCGCCGAGAAGGACTGGGAGACCGTGCGGCAGGGCTACTTCGTGCTGATGTCCACCAAGGTCGCGACGCCCCGCGAGATCCTGGACGAGTACTTCTGCCGCACCGAGATCGAGGGCGTCTTCAAGACCAGCAAGGACTACCTGGGCCTGCTGCCGCTGCGCAAGTGGAGCGACCTCACCGTGCGCGGCAAGATCCTCGCCGACATCATCGGCACCATCGTGGTGCTCAGGATGCGCAAGGCGCTCGCCGGGGCCGACGTCTCCCTCACCGAGGTATGGGGCAAGGCCAGGTCGCTGTCCTGCTACACCAACGCCGACGGCAGGGTCGTGGTCGAGACGCCGTCGAGGCAGGTCCGCGAGTACTACAAGGCGCTCGGGGTGAAGGTGCCCTCGTCAATCGACGTCAGGGAATTCGACCGTGACGTCCTCGGCCTGGAGCTGTAGTTCTACAATTAGCGTCATCTAGGGATGATCTAAGCGCCTGAAGCGATTCCGACGCTGTCTTCTTGAAGGGCTTAAGGGCCTCCTCGAATGCTTCGGTGTCGGATGTAACCGAGCAGAACTTGCGTAGCATTTCAATTATCGGAGCAATTCGCTCGAAAAGCCTCTCCCTCTCAATCGTGACCGCAGCATCTCTGTACACCTGAATTGGAAGGCCATCTTCCATAATGCCATCTGGACTAGCATCAGAAATCGCAAAAGAGCGTGCCTCGTCATAAGCAATTCTCAGCTCTTGCATGTCGGAATACAGATTATCGATATCCTCGCTCATCGGAGCGATTCCGGAACCGACCATTCGCATCGCTGTCTCAAGGGCGTCTTTAATGGACGTGGCAAGAGCCTCGAAGCGTGCGAACGTTTTGTCGTAATCAGCCATCAATATCCCCCAAGAACAATCAAATAAACCTATTTTAAGTATATCGTAATTATTTTGCAACAACAGCCACACCGTTCCATAGACCACTGCCACGCAGCTCCACATAGCACTGCCACACCATTGCAGCCACAGCAAGCAGTTACTTCAAGGCGCTCCAGCGAAGGGAAAGCCTTCCCGAGGTGGCGCGCGACCATTCCCTGGGCGGAGCGTATCGAGGACATCGCGAATGCCATATCGAACCCGATTGGCTCCTCATTTATCGTATCGACGAGGAGGGGCTCATCCTTATTGCCACACGCACGGGAAGCCACAGCGAGCTGCTGGGGCTATGAACGTCGCCAGCGTTCATGGCGAGGCCTCGTTATGCCCTACTGTCACAGGTCGTAGCGCCGAGGCGCAGCGCAACGAGCCCGAGCGGTCGCGACGAAGAGCGAGGTCTACTCGCATCCCCACCGGGTGCGCCCGTGTATGTTGATGTACAGCGGTCCAGCTGCCAGTGCCACCCACCCTCGTCAGGTCGCAACGCCTCACGAAGAGCCACAGCCACTCGCACAACCCACAGGCTCATCAGGCGAGGAGGGACACTGTCTGACACCCCGGCCACAAGGTGCATACCGACGCCAACGCAAGGACAGAGCTCACGCGAGGGATCAGCTCAATGTGCTAGACGGTATGCAGCATATTGAGCTGGGCGAGTAGATACCACGGACTCGGTTCGCCAAGCGTGCCGGCGCCTTACCGTCAAGTACCTTGGAACCTCACCCTCCGTCCTGGGTTTTCTCCTTCCCATGATACAGCCCAGCCTCTGGCACTGCATCTTGCGATGATCTGTCACGCCTGGGGTCGGAAGCCTCACATGTTGTTGCCTCGCACATCGCCATGGGTCATAACATCGGGGTGCGTCACTCGACCGGCAGGTGCCTCTCTACCTATGACGCTCGCCCGATGCGGTTGCCAGCTGGCTCCAGGGCCTTATCTTGTCGAGCTCTTCGCTCATCCTCATACGCGCGAGGTCGGTGTCATACGCGGCCTGGACACGTAGCCAGTAGCCATCGCTGAGTCCGAAGAACCTGCAGAGCCTGAGGTCCGTGTCCGCAGTCACGGAGCGCTTGCCCGACACGATCTCGCCGATGCGCGTCGCCGGTACGCCGATTTCCTTCGCCAGACGGTACTTCGTTATGCCCATCGGCTCAAGGAACTCCTCCTCGAGCAGTTCACCGGGCGCCACGGGATCGATCGCCTCGTCCATTCCCCCTCACCTCCCGTTTAGTGGTAATCCACGATCTCTACGTCTTTCGGACCCGCATCGCTCCACACGAAGCAGATGCGGCATTGGTCGCTTATCCGGATGCTGTGCCGCCCTTTCCTGTCGCCTCTCAGAGCCTCGAGTCGGTTCCCCGGAGGAACTCTCAGATCGTTGATAGTTCCGGCGGCCTGAAGTTGGCGGAGCCTCCTCAGGGCGATACGCTCGAACGCCTCGAAGCGCTTTACGCGCGTGTTGGAGGCGAGCCGCTCCGTATCCGAATCTTTGAACGAAACTATCATGAACATATGATATCGTATCGCGTTATTAACGTCAAGCGTTATTAGTGCTAGGGCATGCGTGTATCTGCCTGGATACAGAGCGAATACCTTCTCGCTGGCTACGTACGTCTCCCGATTCCAGTGAGGGCCCGCTGTCCCTCAACCTGACATCCCGACGCTTCCTTAGCCCGCTGGACACAGGCCCGATCCGTCGCCTGCCCGAGGGCCTGCGCCCGGCTGCGGGGACCCATGGGCCGCCGCCCGCGCGCGGCGGCCGTCTCCGGCGACATGCGGCATGATGCCCTCACCCACGGGGGCGGGGACGCGCGTCAGCCGCGACGTCGCGGTCGCCAGGCCCGCAGGGGACGGCGCCGGGACCGCGAGGAGGACGCGCGTACGGCCCCACGGAGGGGCGTAGCCTGACCCGACGCCTCACGGAAAGGCGCAGTCTGCGGCCCCCGCGTCGCGCAGAATGCGCTTTTCCGTCACATCACCGCCCGGGAGACGTAGGACCAAACCGCCCGCCAGCCTGCGGGGCACTATGGAAAATGGCCCAACTGGGCAAACGCGCTCGAGCAACCCCCCGCCAGGCTGCGGGGGGGGTTGCGCCAGGGACACGCAGGCCTTGGCCTGGGGCCTAGCCGCACGGAAAGGCGCAGTCTGGGCAGAGGGCCTCGCTGAGGGCGCTCCCTGGGCCAAACCGGGACACCATCAGGCTGCCAGTCGTAGCTAAGGAGGTGCCGGGAACTCAGACTCAATCAACTTGTAGATTGACGATGGCGAAGTGCGCAAGCACCCCGCAACCTGCAATACATCGAGCGGGATATCCTCCTAGGCGCTCGCTCCTAGGGTTGAGGAGGTTGTAAATCCCTATTTCCCCGCCCCGGAATCCTTGCGGTTTATCACCCCAAATGCCCCCAATGTACCTCATAGTCGCAGTTGGCATCTGCCCTGAAGCCCAACCGTTCGCGGCAGATTTCACATATTCCAGGACTTCTGACAAAGGGCCCTTGTCTCTCGTGTAAGATAAGCGTGTGCAAGGCAGATAATATGTAGACGCGCACGTTCGGAGGTGTCATGCTTCCCTTTGGCCGCAAGCCCCATCAGAATGACGCCGGCACGTCGCCCGATGACAATGAGTCGGCGCGCAACGGACGGCACATGGCCCCTGTCCCCGGGACTCCTGCGACCCCCGACAAGACGGAGGTCTTCGAGTCGCGCATAGGGGTCATAGGCCCGGCCGATGCCGACGAGGACGCCGAGGCCCGCGAGGCCTATGAGAGCCTCATGCGCCACCGCAGGGTCCGCAGAAGAAAGAAGCGCATAAAGGTGGGCGTCATCCTTGGCGTCGTGGCGATCATCGGCATCACCATCGCCCAAGTCATCCAGGGCGGCGCGCAATCCGAGAGCCCCGCCATAAGCACCGCGTTCGTCACGCGCGGGGAGTTCAGCGACTCCGTGTCCGCCTCGGGCTCCATCAAGCCCGTCTCCTCGACGGTGGTGACGCCCGAGGTCGACGGCATCATCCAGGACGTGCGGGTCGCGGAGGGCTCCGCCGTCGACAAGGGCGACAGGCTCTTCAGCGTCAAGAACGATGAGCTTGACAAGGCCGTCCGCAAGGCGGCCCAGCAGGTCAAGACGGCAAAGAACGAGGTCGGCAAGGCCCAGGCCGCCCTGGAGACCGCCCGCAAAGGTGCCGCAGCCGTTGCCGAGGGCGGCCAGAGGGGCGACACCTCGTCGGTCGAGATGGCAAAGACGGATCTCGAGAGCGCCAAGATCTCCCTCGAGGAGGCCCGCTCGGCCTATGACGACGCGGTCGCCCAGGCGGACAAGCGCACTGTCACCGCCCCGTGCGACGGCACGGTCATCGTCATGAACGCCGTGAACGGCGCGTCGGTCGGCTCGCCTGGGGGCGCGGGCGCAGGCGCAGGCTCGAGTGCGGGCGCGGGCTCGGCCGGGGCGCTGATGACCATCGCCGACCTCTCGAGGATGAAGGTGACCGTGCAGATAAACGAGGTGGACGTCTCTCGGGTCGCCGTCGGCCAGAGGGCGAGGGTGACGTTTTCCGCCCTCCGCCAGCTCGTCTGCGAGGCGCAGGTCACGCACGTCTCCACGGTCTCCTCCTCGGAGGCGGGAGGCTCGGGCGCGGGCAGCGGCGGCCCGGGCGCGGGCTATGACGGCGGGGGGCGCGCCATCGTCACCTACGCCGTCGAGCTCCTCATCGACAGCCCCGACGCCTCCATCAAGCCCGGCATGACCGCCAACGCGGACATCATGATCCAGCAGATAGGCAACGCGCTCAACGTGCCCCTCTCCGCGCTCACGGAGGACGGCGCGCAGGCATACGTGAGCGTCGTCACCGCGCGTGACGAGAGCGGCGACCCCCAGACCAGCCGGGTGCCCGTCACAGTCAGGGCAAGGAGCTCCACCACCGCAGCCATCGAGGGCGACGGCATCGAGGAGGGCACCGAGGTGCTCCTTGCCGGCGGGACGGGAGGCTCGGGTAACGGCGGCGGCCCGGGCGGCGGCCCTGACGGCTCTGGCGACGGGGCGACGGCGTATGGCGGGGGCGGTGTGTGAGATGCCCAACGTGATCGAGGCGCATGGGCTGCATCGCATATATGAGACGGCGGCGGGCCTCACGCATGCCCTGCGCGGCGTCTCCCTGAGCGTCGGGAAGGGCGAGTTCCTCTGCATCATGGGGCCCTCAGGCTCGGGGAAGTCTACCCTCATGAACATACTGGGCTGCCTGGACACGCCTACCACGGGCTCCTACAAGCTCGAGGGGCTCGAGGTCGCCGACCTCTTTGACGACGATCTTGCCGAGATCCGCGCCACGCGCCTCGGCTTCGTCTTCCAGTCGTTCAACCTGCTGCCCCGCACCACGGTGCTGCGCAACGTCATGCTGCCGCTCGTCTACTCCGACATCCCCGTCTCCGAGCGCGAGCTGCGCGCCTGGAGGGCGCTGAGGTCGGTGGGCCTGCCCGAGGACTACTACGACCACCGGTCAAACGAGCTCTCCGGCGGGCAGATCCAGCGCGTGGCCATAGCGCGGGCGCTGGTCAACGACCCGGCCGTGATCCTGGCCGACGAGCCGACGGGCAACCTCGACTCCGCGACGGGCGAGATGGTGCTCAGGACGTTTCGCGCCATGCAGGATCGCGGCAAGACCATCGTGCTCATCACCCATGACCCCGAGATCGCCGCGTGGGCGGACCGCACCGTGCACATACGTGACGGCCGCCTGCTCACGGACGAGCAGGAGCGCGCGTTTGTCCTGCAGCATGGCGCGCAGGAGGCCGCGGGGGGTGGGGGCGCATGAGGCTTCGCGACCTGTTTCTGGAGACCCTCTCGGCGTTTAACGCCAACCGCGGCCGCAGCCTCCTGACGATACTGGGCATCGTCATCGGCATCAGCGCCGTCATCGCCATGACCTCCCTCATCGACGGGATCAAGTACTCCCTGCTGGGTTCCCTGGGCCTCAACCAGTCCCGCATGGTCACCATATATGCGGCGCCCGATCGCGGGGTGACCGAGCAGGACCTGGAGCAGCTGGCGATGGGCATCCCCGACTACGAGTTCGTCACCGGCATCGACTCGGCCTCGGAGCGCCTCGGCTCGGCTGAGAAGCAGTTTGACGCGCGCATCACCGGGTGCAGGCCTGAGTACTTTACCGTCATGGGGTTTGCGGCCTCAACGGGATCGCTCCTCTCGCAATCCGACGTGAGCGGCGAGGCAAGGAACGTCGTGCTCGACCGCGTGGCCGCCGAGAAGGTCTTCGGGAGCGAGAGGGACGCCGTGGGCAAGACGGTGCGCATCAACAACGGCGACTATACCGTGGTCGGCACCTGTGACAGCGGCCAGGGGGCGAGTGGGGGCGAGAGGTCCCTCCTGTCGTGCTACATGCCCTACTCGACATTCACGACGCGCGTCTCGGGCAGCAAGGCCATCAGCGAGATCTATGGGTACGCGCGCGAGGGCGCCAACATGAAAACCCTTGCCGAGCGGACGAAGGCCTGGCTCATCGACTGGTTCTCGATCCCCGAGAGCGAGGCGGAGGGCCGGATCAGCGTCATGACACTCTCCTCCATCATCGAGCGGCTCGATGCCACCATGGCGTCGTTCCAGGTGCTTGTGACGGCCATCGCGGGCATCTCGCTTCTGGTCGGCGGCATCGGCATCATGAACATGATGCTCACCAACGTGACGGAGCGCATCCGGGAGATCGGCCTTCGCAAGGCCCTGGGCGCACGGGCCGCCGACATCACGAGGCAGTTCCTGTTCGAGTCGATACTGCTGTGCGTCACGGGTGGCGTCATCGGGGTCGCCCTCGGGTATGCCGCTGCGTGGGGCCTGGCAGGCTCGGCCTCGGCCTTCCTGCACATGGAGACGTCGGTCACGCCCATCATCACCCCGTCGGTCGTGCTGATGACCTCGGGGACCTGCATTGGGATCGGGCTCGTGTTTGGCTACTGGCCCGCGCGCCGGGCGGCGAGGCTCAACCCCGTGGAGTCGCTCCGCTACCAGTAGGTGGTGGGTCCGGCAGAGGGCGTGCCCCGCTGAGGATGTGCCCACAGGGGGCGACTCCCTCTGAGGGCGACCGCCTGTCGAAGGGCGTCAGGTTGGGGGATGCTCGATACCCCACGGTAGACCGGGAGATGGAGCCCAGGTGTTAACGGCAAGCGAAATCAACCCTGAGTTCCCGGCACCTCCTTAGCCCACGACTGGCAGTCTGATGGCGTCCCGGTCTGACCCAGGGTGTGCCATCAGCGAGGCCCTCTGCCCAGACTGCGTCTTTCCGTGAGGTCAGACTCCAAACCGAGATCTGCGGGTCTTGGCGCAACCCCCCCGCAGCCTGGCGGGGGGTTGCTTGGACGCATTTGCCCAGTTGAGCCACTTCCCATAGTGCCCCGCAGCCTGGCGGGGGGTTTGGTCCCACGCCTCCACGGGCGCCGCGACGTGACGGAAAAGCGCATTCTGGGCCGCCGCCTTACACACTCTGCCCCGCCGCCTCACGGAAAGGCGCAGTCTGCAGCCCGCAGGTTGGGCAGAGTGCGTCTTTCCGTGAGATCAGACTCCAAACCGAGATCTGCGGGTCCCGGTACAACCCCCCCCGCAGCCTGGCGGGGGGTTGCTCGAACGCATTTGCCCAGTTGAGCCATTTTCCATAGTGCCCCGCAGGCTGGCGGGGGGTTGCGCCCCGCGTCTCCCGGGCGGCAACGTGACGGAAAAGCGCACTCTGCGCGACGTGGGAGTCGCAGACTGCGCCTTTCCGTGAGGCGCCGAGCCGGGATGCGCCTCGCCGTGAGGCCGCACGCGTGTTCCCCCTCGCGGTCCCGGCGCCGTCCCCTGCGGGTCTGGCGGCCGCCACGCGCCCGTCGCCGGACGCGGGTCCTCAGGGCAGGCGACGGCTCGGGCCTGTGTCCAGCGAACTAAGGATGTGTTGGGAAGTCAGGGTAACCACATGGGGGCTGCGGTGGGGATCCTGGTCCTCCTGATCCTGCCTCGGTCCCAAGATTCCCACGCAGTCCCCCATGGTCACATCAGCCTAGCTTGAGCAGCTCCTCGCCTCTCTCCTCTCACGTCCCTCCTGAAATTAGGAACGGGAGATCGAGCCGCCGTTTTGCCCGTCTGACACCTTATCCCAGGGGTTCTCGGCCTTTGGCGGGTACTTGGTGTAAGACCAGTTGTCCGGGTTGTGCGTCGTATGAACAAACTTGATCGTATACTGAGGAACCTTCAGGATAACGATTCTCTCGTTTTCAGGATCAATGGAGATGGTCCCCTCGTCGGAAAGCTTGCCGTTGGTTCCTTGAATATAGACTGGGTAGGTTCTGCCATCTGCAGAGGGGTTTTCGACAGCAACCTGCATGCCATACACGTACTCGAGCGCAAAGAGCGCGGAGTCCCCATTGGTGCGGATGGACATGTTATAGCTGAGGCCAGAGTCAGCGCCCGCTGCAGCGACGCCCTTCTCATCCAGATCGGTTTGGCTTGGATCGCTGTAGTCGATGCTGACAATGGCGTAGCTGCCAGGAAGCCAGACTCCAACGTTATTGAGCTTCCCCTTGACGTAGGTCAGGTTAGAGAGGTCGGACGGATCGTCTGAGACCTTCCTCATGTGAGTCGTGACCTCGTCCGCGAGGGACAGCAGGTGGGTGGCCCTGTCATAGCTGTACTCATGCTCGTTGCCGTCCGCGCCGACAAACGAGATGGTATTCTCGTCCTTGGCTTTCCACTTGAAACTGGTTTGTTTCCCAAAGTTATCAATCTCAAGCGTGCCATCATCCTTGAAAGTCCATGTCAGAGTGCCTGTCTTGTTTTCGGTAAGATCAAGATAATCTCCGCGCGTCATGGTTTTTGACCCACTCGCGCTGTCCATGTCCCAGACACCGACAACGACGCGAGAGAGGTCCCCATCAAGGGTAACCGCTTTGGTTGGGGCGTCGAGCATCGCCTTCTTCGAGCCCTGACCACCCTTCTGGTCCTGGCTCTCAGTGGTCTGAGATTGACCAAGTTTGGGCAAACGGCTACTATCGCAGCCAGACAGCGAGATAGTAAGTGCCAGCGCCACAAGGCCGGCGAACGCGCATGCAAAGAACTTGTGGTTCCTCATAAGCTCCTCTTTCTCCGTGGACTCTTTTCTCTCGAACGTCCCTTGAACGTGTCTCGAACGTATGCAATTACGATAACAATACCGTATTTTTCGGGCGATGTCGTCACAGGCAGGCAACGTCGTCACGGAACGTGGAGCCAAGGTGGAGCGCAACGGGAGCAAACCTGAAATCGGTCGCATCGTCTTTTTTCTTTCGGCCAGCTCAGCGAGGCAAAACGGCATGTATAGGGGTAGGTACGTGAGCCTCCCGTCCCTCGAGACGTTTTTGCGCGAGAGCACGAACGCCTCAAAGATCGCGCTTCCACTTATCGACAGTAAAGATCCCCCGGCGTAGCCGGGGGCTTTAGTAACGCCCCATAGGGGCCCGTCACGACAGCGGCATCGCCGCGACGGGCCGGTGGCCGCTGCCGTCAGGCCCCCGTCGGGGGCATTCCCGCTACCCTGTGCGACTCCCGTCAGACTGCCGCTGGACGTGCCTCCTGATGACCGACTTGTCAGGGCCGACGGTGCCCGCGCGGTAGCCCCTCGCCCACATCGTCCGGTCCCTGCCCGTAAGGGCCCCCCGCTCATGGTGCCGCTCGCGCGGTATGATCGCGCTCTTACCCCTCGACCTACCCACCACGTCGCCCGCGCCGCGCCTGGGTGCGATCCGGAGGCAGATGCGCGTGTGGTCGGGGCGGGCGCTCCCCTCCACCATCCCGGCGCCGCCCGTCCTGCCGGCCAGCATCCCGGGCGTCTCGCCGACCTCCCTTTCGGTCTCGCCGCACGGCACCTTCCTGCGACGCCTCGGTACCCGCGCCACGTGGCACGCGCGATACCGGCTCGTGTGCGATGGGCTATCCTTGTCCATAGTTCCCGCCCCTCCCGGACGGCGCAGCCGCCCCTCCGCGCCTCCATGGTAGGGCGGGAGCTGCTATTACGGAAAGACGATAGGGGTGGAACCACCGCTGGCACCACTGGCATAGCCAGTGGTTTTCTCACCAGAATAAGTTGTCGAAGACGGCATGGGAACGTACCTTCATCCCCAACTTGACCTCGACACGCCGATAGCCCAGCAATACTCCTCGAAATCCATGAGCCGCATGATGATTCGCTCGATGAAGCCCACAGGAAACGATGAGATGCCCTTGAACCCGGTCCCCAGCACGGAACTCACAAGACGAACGAGAAACGACCGTCCTCCACAAGGCCTTTCACGAGAGTGACGATCTCCGGATATTCTTGGACCTCGTCTACAAAAATGAGTGTGTAGCCCTCGACCAAGGTGCGCTCCGAGAGCATGGTAACACGCAAGATGAAGTCCCCCGCATTCCGTGCCCCTGTAAAAGTCTCGCGCGCATCTACATCAAGCAGTAAGTTGGTCTCATGATAGACGGTATAGTTCGCTTTACTAAACTCACGGATGGCATAGCTCTTGTCAGCCTAGCGGGCACCTGTCACAAGAAGGGCCTGCGTTGAAGTCCATCTCCAACGCAGCAGGCGCTCAGTGAGCTTTCTTCTCAGAACATCGTCTCTCTGTACGCATTAAAAGATCGATACGTACAGATAGTACATGAATTGGAAGATAGAACGCAGCTGTAGCTACATTAACTCAGGAATAGCTGTAAGGTGCCTTGCACCGGCGTCCCCGTGATCAAAGGCGAGAGGACCGCTGCGCGGACTGGGCGGCCGTAGGGCCTTTCGGACCTTTTGGGGCGGCTCCCTGCCTCGCCGGGCGTGACCCATCCGGCGCTTTCCGAAGCGCATGACCTACGAGAGGGTCGGCGAGGGGCGTATCTCCATGAACTTGTAAGAACGCTTGTTCTTACACCGTGCTATACTATTTAGTGGGACAGGGTAGTTGGAAGAGAGGCGGTGGCCGGATGGCACAGGCGAGGTGGGACATGGGCGCGCTGAGGCCCATAGACGACCTGATGTTTCGGGTGATGGCGAGGGACAAGGCCTTCTGCGGGGAGCTCCTGGGGGTGCTGCTCCAGGACAGGGGGCTCGAAGTGGTGGAGTGCAAGCCGCAGTCCGCCGTCACGAATCCGCAGGGGCGCTCGGCGGTCCTCGACGCCCTCTGCGAGCTCTCCGACGGCAGGTTCGTGGACGTGGAGGTGCAGCGCGCCGACGATGACGACCTCCAGAGGAGGGTGCGCTACTACGCCTCGCTCGTGACGGCGGACAGGACGCGTCCGGGAGGGCGCTTCGCCGACGTCCCGGACGTCTGCGTGGCGCTCGTCTGCGAGTTCGACCCCCTCGGGGAGGGCTGCTCGCTGTATCATGTGGACAGGGTCGTGAGGGAGAGCGGGCGGACCTTGGAGAACGGCCTCTCGGAGCTCTACGTGAACGCCCTGGCGAGGGACGGCGGCGAGGTCTCGGCCCTCATGAGGGTGTTCACGGAGGCCGAGGCGTACGATGAGGAGCGCTTTCCGGAGACCTCGAGGGTGAAGAGAAGGCTCAGGGAGACGGAGGAGGGGCGAAAGGACATGGGCAGCGTCATAGAGGAGATTCGAGAGGAGATCCGCGCGGAGTGCATCGCGGAGGGCATCGCGGAGGGCATCGAGACGGGCAGGGCCGAGGGCATCGCCGAGGGCGAGGCGAGAGGCGAGGCGAGAGGCGAGGTCAGGGGGACGCTCAAGACGCTCGTCCGGCTCGTGCGTGACGGGCTCGTGAGCGTGCAGGACGCCGCCGCATCGGCGGGGGTGGACGCCGACGAGATCAGGCGCACGCTCGCTGCGGAGGGGTGA

Protein sequences of DBSCAN-SWA_3

>NZ_CP012069|1873337:1899481|1893454_1894666_+|WP_050340649.1|DBSCAN-SWA
MRLRDLFLETLSAFNANRGRSLLTILGIVIGISAVIAMTSLIDGIKYSLLGSLGLNQSRMVTIYAAPDRGVTEQDLEQLAMGIPDYEFVTGIDSASERLGSAEKQFDARITGCRPEYFTVMGFAASTGSLLSQSDVSGEARNVVLDRVAAEKVFGSERDAVGKTVRINNGDYTVVGTCDSGQGASGGERSLLSCYMPYSTFTTRVSGSKAISEIYGYAREGANMKTLAERTKAWLIDWFSIPESEAEGRISVMTLSSIIERLDATMASFQVLVTAIAGISLLVGGIGIMNMMLTNVTERIREIGLRKALGARAADITRQFLFESILLCVTGGVIGVALGYAAAWGLAGSASAFLHMETSVTPIITPSVVLMTSGTCIGIGLVFGYWPARRAARLNPVESLRYQ
>NZ_CP012069|1873337:1899481|1875381_1875708_+|WP_050340639.1|DBSCAN-SWA
MADHTNLEALISDTLVEMGRLGYSENTMTGLGRMFAALSRYAVSQGRKESGEELAIRFPDAKFGVELTQPCQANPGGGHPRAWLRAMRVLLEMGECGRVCKRMPGDLA
>NZ_CP012069|1873337:1899481|1877836_1878658_+|WP_050340641.1|integrase|DBSCAN-SWA
MKGEDPARLPQYQQVLAMRQRKGKPGAMAAPGRDGLAAILRDPGMSTPGGRRDTAPPAVPCDGAARVSELCGITPRDLRSGDPAVVTPRGRGRKAGTVPLMHATAGLPRGCVSEAYPGLGPRDLDKPLFPNPRGDHPARAGVADILARHADGARKSGADIPEGVSPHSFRHQRATGLPGSGREPRPHEGSSRPQERHDHRDLRDRGHGEEARTAGEGRNGTQGRGIPRPDSRQRPHGLAQGPLLIWGYAKGRGCRERMTCGGSPFPDIIRFSA
>NZ_CP012069|1873337:1899481|1888731_1888944_+|WP_083443897.1|DBSCAN-SWA
MAATASSYFKALQRRESLPEVARDHSLGGAYRGHRECHIEPDWLLIYRIDEEGLILIATRTGSHSELLGL
>NZ_CP012069|1873337:1899481|1888138_1888705_-|WP_157051456.1|DBSCAN-SWA
MAVVYGTVWLLLQNNYDILKIGLFDCSWGILMADYDKTFARFEALATSIKDALETAMRMVGSGIAPMSEDIDNLYSDMQELRIAYDEARSFAISDASPDGIMEDGLPIQVYRDAAVTIERERLFERIAPIIEMLRKFCSVTSDTEAFEEALKPFKKTASESLQALRSSLDDANCRTTAPGRGRHGRIP
>NZ_CP012069|1873337:1899481|1892717_1893458_+|WP_050340648.1|DBSCAN-SWA
MPNVIEAHGLHRIYETAAGLTHALRGVSLSVGKGEFLCIMGPSGSGKSTLMNILGCLDTPTTGSYKLEGLEVADLFDDDLAEIRATRLGFVFQSFNLLPRTTVLRNVMLPLVYSDIPVSERELRAWRALRSVGLPEDYYDHRSNELSGGQIQRVAIARALVNDPAVILADEPTGNLDSATGEMVLRTFRAMQDRGKTIVLITHDPEIAAWADRTVHIRDGRLLTDEQERAFVLQHGAQEAAGGGGA
>NZ_CP012069|1873337:1899481|1897904_1898156_-|WP_083443899.1|DBSCAN-SWA
MREFSKANYTVYHETNLLLDVDARETFTGARNAGDFILRVTMLSERTLVEGYTLIFVDEVQEYPEIVTLVKGLVEDGRFSFVL
>NZ_CP012069|1873337:1899481|1898614_1899481_+|WP_050340653.1|transposase|DBSCAN-SWA
MAQARWDMGALRPIDDLMFRVMARDKAFCGELLGVLLQDRGLEVVECKPQSAVTNPQGRSAVLDALCELSDGRFVDVEVQRADDDDLQRRVRYYASLVTADRTRPGGRFADVPDVCVALVCEFDPLGEGCSLYHVDRVVRESGRTLENGLSELYVNALARDGGEVSALMRVFTEAEAYDEERFPETSRVKRRLRETEEGRKDMGSVIEEIREEIRAECIAEGIAEGIETGRAEGIAEGEARGEARGEVRGTLKTLVRLVRDGLVSVQDAAASAGVDADEIRRTLAAEG
>NZ_CP012069|1873337:1899481|1880402_1881401_-|WP_157051455.1|DBSCAN-SWA
MRDMLREELQSTSGTESLAITFLDAEEDLPGEYEPGKYLVDKFGLRDDSLHYRSSRGSGQGYLLRRGVLRNKIVWIKGLGVDDAQVWERFCAGWNISTLDEGLFVIEDRTSETSVPQNLTIIDYAECVDEYSVQLFNGLTLNSQEFDSYKMVWKRYVAALMTSLCGSDVEVAHELVWSHDLRKEDAYVAITTMVDSGIFDSRGHGSFGHVLNVARRGDKATIDERIWAAQLEVLFPMIERERLLIVEKLSDSISPLIDGGRIEQHGDKLTSLEDVELGTLVYLMNCDQDGVRVLDVKEKGLRDRIFLLRKCRNHLAHHRCCGMDQVSQLLNS
>NZ_CP012069|1873337:1899481|1886562_1888179_+|WP_050340583.1|transposase|DBSCAN-SWA
MPFIKVQKLVRDESGAIRSGSAAVVDTSYVRGAKYHSAQAVRERLGKVVWLADDRRSGVFASPTRGLVEYDADADGFAPVAKGDERLANTGAFPEPPRHLELGPEHLLLSFLGADGVAGCLREALPDDRSYQRALAHVTHGVVRDGSRETCDNMVARSFAALALPGVPPASLRSDTAFFSAMGADGAKVAFFRAFARLMRRTKPGFGRACYVDSTPLPNDAVDNPLNALCSHGLRGAAVQMRLALVLDETTGLPVWYEVVPGNVLDLSTIKTVMGDVLATLGIEVVTAVLDAGYASRELLEAFSEGERDVLVRMPARRGYPYRELWRGVRSLIGKGKYAITRSGHLYFARRRDVEVQGVRLHCYVYVDQTNATPRFARWLDKNQERFDGMSLAEKDWETVRQGYFVLMSTKVATPREILDEYFCRTEIEGVFKTSKDYLGLLPLRKWSDLTVRGKILADIIGTIVVLRMRKALAGADVSLTEVWGKARSLSCYTNADGRVVVETPSRQVREYYKALGVKVPSSIDVREFDRDVLGLEL
>NZ_CP012069|1873337:1899481|1889878_1890157_-|WP_050344502.1|DBSCAN-SWA
MIVSFKDSDTERLASNTRVKRFEAFERIALRRLRQLQAAGTINDLRVPPGNRLEALRGDRKGRHSIRISDQCRICFVWSDAGPKDVEIVDYH
>NZ_CP012069|1873337:1899481|1889537_1889861_-|WP_050340647.1|DBSCAN-SWA
MDEAIDPVAPGELLEEEFLEPMGITKYRLAKEIGVPATRIGEIVSGKRSVTADTDLRLCRFFGLSDGYWLRVQAAYDTDLARMRMSEELDKIRPWSQLATASGERHR
>NZ_CP012069|1873337:1899481|1891213_1892716_+|WP_083443898.1|DBSCAN-SWA
MLPFGRKPHQNDAGTSPDDNESARNGRHMAPVPGTPATPDKTEVFESRIGVIGPADADEDAEAREAYESLMRHRRVRRRKKRIKVGVILGVVAIIGITIAQVIQGGAQSESPAISTAFVTRGEFSDSVSASGSIKPVSSTVVTPEVDGIIQDVRVAEGSAVDKGDRLFSVKNDELDKAVRKAAQQVKTAKNEVGKAQAALETARKGAAAVAEGGQRGDTSSVEMAKTDLESAKISLEEARSAYDDAVAQADKRTVTAPCDGTVIVMNAVNGASVGSPGGAGAGAGSSAGAGSAGALMTIADLSRMKVTVQINEVDVSRVAVGQRARVTFSALRQLVCEAQVTHVSTVSSSEAGGSGAGSGGPGAGYDGGGRAIVTYAVELLIDSPDASIKPGMTANADIMIQQIGNALNVPLSALTEDGAQAYVSVVTARDESGDPQTSRVPVTVRARSSTTAAIEGDGIEEGTEVLLAGGTGGSGNGGGPGGGPDGSGDGATAYGGGGV
>NZ_CP012069|1873337:1899481|1874907_1875324_+|WP_050340638.1|DBSCAN-SWA
MIDDETRRKLRETSMSEMVDALDLQEGDRTIMSVPFDERVRMVVDHAWEAKRASSARRLTQRARLRFPDAEPGEMIYDGRGIDGVLIREAMACQFMSRAANVVIEGCTGTGNYAEKRIMSGNGLPPQVICSRRPRPLA
>NZ_CP012069|1873337:1899481|1873337_1874897_+|WP_050340637.1|integrase,transposase|DBSCAN-SWA
MARKIKAKLITRLREQGMSRRQIAKTRRMSMGSVCEVFPVADERGIGWKDIEGKSDEGACVLLCPDRHVRGSVFEEPDWGYAHKEMARVGASLRLPRDGHEDGRGRTGKVAMGHARFCERRGKHVAANNLTKRIEHKAGQSCEVDWSGPTLGRGLVDPTTGEVSKIHLFVGVLPFSQRAYLGPTLDMRERTWLRCHVHTCEYWGGVPERTVCDNLKTGVVRHPREGEVVPDDAYEAPGEHHVTAIMPAQVRKPKQKASAEGTVRDAATWVIAQPHDATLADFGQAKAAVREKLDERDAHPFQKRQGSRDPVFAEAEAAELSPLPDVRYDVAEWVHGRSVALDSRVAHERNRYSVPHRYVGRKVDLRVGESTVSIYHAGERIATHSLLPEYAGNGYSTDRSHMPEAFLKPEWDDARIRGWAKRIGPSCFEVIGRIFARVKVKEQAYNPALSVPDLSKKYGDERLEVACAYALPKLTSPRYKHLKAILDANLDQEGPAEDGPGETRDAPKGHVRGADYYRD
>NZ_CP012069|1873337:1899481|1897188_1897602_-|WP_050340652.1|transposase|DBSCAN-SWA
MDKDSPSHTSRYRACHVARVPRRRRKVPCGETEREVGETPGMLAGRTGGAGMVEGSARPDHTRICLRIAPRRGAGDVVGRSRGKSAIIPRERHHERGALTGRDRTMWARGYRAGTVGPDKSVIRRHVQRQSDGSRTG
>NZ_CP012069|1873337:1899481|1881552_1886409_-|WP_050340645.1|DBSCAN-SWA
MSAGELEDLGDIDDQYKPQRVFVQALECDNLSTTVGIDLLDMITQSYPTRVQQGVALRIYRFGEYCDAGLEGKKGNIRDGASVVPTETNGHAEQDAVSTVKEEFHAPYPHLNRPKRTGSSSFKKLLLKSPNLVVALTFAALARFRCMTIEALQRLAVVVFGKDESLSPDAVTLSASYLAQKGIIEKAGFEFENSDAFVLSEDGCQLARKDSVINMMNSHSRSTWFFPYVDAKRNIPGCDPSASSMEMLAQNDVLLSFLESSMGSGHKLMLYRRLQGCYWDGNHYVIQCEVGGSRVEGILARRTASVPEGATNAFVLDVPSDEERFACGVTHLFVITDSGIQEVAKNESASSQERLLSNDKGTPNLSVEESGSINSETDQTISAKEAHGNEQLSAGVAQIEQRADDSDGSRRDNSSDPSTERISLSAMAESILRGNLEISDEIVTKFATRLMEEIPSDDGADSLVNLETALTLLKSVHGQVKFGHSSALYEQVSLAVNSPLECEEYTGANIKSTFPTYSKENEGFVLAAYCLALLAPKHSYDHELYKTCESYLNSFDTVFPSFSRAKPLFSELINVCDILPEGGFTSSVLAGIGGDVERRRAMDRIRAKAKTLLRPPKFNAKMSHLPVFSQICFGSNSDLSPCLDIIVRGREDKAFLVEKVFEAYCVDGKLSDRLIESLIDNAWSKAINAKGNKGPRRLAMESRRKASDEIYDRLGLMEEWLEHVRGSVNESEIEEIREIRDSLLTLSDEIISMNLFIGQQGGGTALHTAVREIKTRLSGSCGRVLTFSDFLRTGLLPTGVDGLPVVEGSLCNVSHCEPWKAVLRHYIADKPSFTDVKNQIGDDDSPMFDNLSQLFAISKMVDKAEAVEPSKDIKTIALQSAEAELAKFNDQLEIAFTYNRINEVQKEDLASYAREFKNLFYSVKEYGCWREFLRALFKQVDDLSADHSFLLEERLASCRGSISGGDSTLLDEAEKLLREDKNLTVVEEYLNRFESGERQLTEKLRSGMSEQDDFARFISGEFYQTIFDVCRKYKGRPLASYGIDFTRKRYPKSWTERQKKNSESLVQNWPVSQKRQVKDWSQNIGELFKGLGFSIKGVAKPDSIGREIYRLEVRPVSRDRESYDHPISAFGTQMNKKIEVLVLYGNQTPQDIIRAVVDSGLSNCSFVLVNYSISLSDRRTLAELYHKRQASMPSFLVIDQVLILFLALNESATRLSVMLKCTLPFTSYQPFVRDGGATADEMFCGREEELRAITNPSGAGVVYGGRQLGKTALLQRARSLCNKPDKGEYAVYVSILQCDTEQDLISTLASAASRAGLDFNGVHSIVDLCDRIREILADRAVSKVLLLIDEADNYLASISSEGYLPLQPLVELRRESENKFKFVLAGLHNVSRAKNATTKNGIFGQLGSPLCIRPLSPAEALRLISRPLMFLGFQVDRYPHLETILTSTNYYPGILQFFGNILVETMSSQYSEYYRAQDGNPPYSLTKEQLGAIMSRTDLNNSIKEKFRLSLELDPRYFMIARCIALLYYEAEESGGEGTLAGYSPTEVKHTADEWDIKTLADESASSFGNLMDEMVDMYILAKPDQDTQRYRLRRHAFLSIIGKDADMILDDIANNDA
>NZ_CP012069|1873337:1899481|1879246_1879543_-|WP_050340643.1|DBSCAN-SWA
MIRHGEILRLTALGISQRSIAGSVGCSKTTVQEVQRKAATRRLEWPLSDEMGDEAIRARPCPPQDRSDASKAEIDHEWARREMGRRGVTMTLVSAGRV
>NZ_CP012069|1873337:1899481|1876618_1877566_+|WP_157051454.1|integrase|DBSCAN-SWA
MAFAKITSAYVAERRAVGPRCERDDRVMARIAASRGELGCPEDELPRALVEARAARRPGESETTGPCRAGRARGPADRMMRAGYDAYVAPGRRGRADRGAHGPHIFTDAELASPSPAAGAIAGGDPASRRAQAARPPGLPCSSGLRCGEACSLAKGDVAPEAGIPAIRHAKNGKGRLVPPRPSMTHMLRIFHDTAALRHPQYGGHGLFWSLPEGRPTATGFACRFFRKALWAAGISHGGRGRGPRVRDLRLAFACHRLRNWVREGADADAMMPPLAAHVGHADIRRAEYYLRPAAGTCPGMVARAGRECGWVVPS
>NZ_CP012069|1873337:1899481|1895732_1896752_-|WP_050340650.1|DBSCAN-SWA
MRNHKFFACAFAGLVALALTISLSGCDSSRLPKLGQSQTTESQDQKGGQGSKKAMLDAPTKAVTLDGDLSRVVVGVWDMDSASGSKTMTRGDYLDLTENKTGTLTWTFKDDGTLEIDNFGKQTSFKWKAKDENTISFVGADGNEHEYSYDRATHLLSLADEVTTHMRKVSDDPSDLSNLTYVKGKLNNVGVWLPGSYAIVSIDYSDPSQTDLDEKGVAAAGADSGLSYNMSIRTNGDSALFALEYVYGMQVAVENPSADGRTYPVYIQGTNGKLSDEGTISIDPENERIVILKVPQYTIKFVHTTHNPDNWSYTKYPPKAENPWDKVSDGQNGGSISRS

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_050340637.1|1873337_1874897_+|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_050340638.1|1874907_1875324_+	hypothetical protein	NA	NA	NA	NA
WP_050340639.1|1875381_1875708_+	hypothetical protein	NA	NA	NA	NA
WP_157051454.1|1876618_1877566_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
1877076:1877090	attL	NA	NA	NA	NA
WP_050340641.1|1877836_1878658_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_050340643.1|1879246_1879543_-	hypothetical protein	NA	NA	NA	NA
WP_157051455.1|1880402_1881401_-	hypothetical protein	NA	NA	NA	NA
WP_050340645.1|1881552_1886409_-	ATP-binding protein	NA	NA	NA	NA
WP_050340583.1|1886562_1888179_+|transposase	transposase	NA	NA	NA	NA
1886801:1886815	attR	NA	NA	NA	NA
WP_157051456.1|1888138_1888705_-	hypothetical protein	NA	NA	NA	NA
WP_083443897.1|1888731_1888944_+	type II toxin-antitoxin system YafQ family toxin	NA	NA	NA	NA
WP_050340647.1|1889537_1889861_-	HigA family addiction module antidote protein	NA	NA	NA	NA
WP_050344502.1|1889878_1890157_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_083443898.1|1891213_1892716_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_050340648.1|1892717_1893458_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.5e-30	39.4
WP_050340649.1|1893454_1894666_+	ABC transporter permease	NA	NA	NA	NA
WP_050340650.1|1895732_1896752_-	hypothetical protein	NA	NA	NA	NA
WP_050340652.1|1897188_1897602_-|transposase	transposase	NA	NA	NA	NA
WP_083443899.1|1897904_1898156_-	hypothetical protein	NA	NA	NA	NA
WP_050340653.1|1898614_1899481_+|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_4

Nucleotide sequences of DBSCAN-SWA_4

>NZ_CP012069|1948941:1960782|DBSCAN-SWA
ATCAGCATCGCCCCACCCTCGCGCCATCGATGGAAAAGGCCTTGCCGACGAGCGCCGAGCAGACCTCGCAGGTCCTCTCGTCGCCCACGGGCTCCACGCGGTACTCCTCGAAGCCCTCGCGCGCGAGCTCCGCGAGCTGGGCCTGCCTGGAGACGTAGGTGCCCTCGGTCACGACCAGGCGCATGACGTCGCGCTCCGAGACGTCCACGAACCTCCTCGACAGCTCGTCGCACAGGCGCCGCCAGGACTCGCCGCGCGCGAGCGCCTTGGCCATGTCGTCCTGGACCCAGGCGGCGACCCTCTCTGAGTCTCCCCATATGGCCTCGCTGTAGCTCTTCCCCGAGGCCCACCTGGTGCCGACGAAGCGGAGGATCGTGTCGTCGTCGAGCGCGTGGAAGCCCTTGCCATACCCCATCACATCAGCGACGGTGTTGGCGCCGCGCACGAGAAGCAGTTGAGAATGCCATGGCAAAGACGAGGGAGGCAATCGCGGATGGTCTCTTCGAGAGAGGTCGAATCTTGATTCTCGACTGGCATGGGGCCGAGCACATCGTCTAGAGACAGAAAAAGAGGGCGTACCTGCCCCTCAACCCGAACCTAATGCTCGGGCGGACAGCGCTGCACCCTTAGTTGCAGTATACCCGATTCCCGGGAAAATAGGAGGCAAGATAATCCTCTTCAAGGACGCCACGATTCCCGTGGACGTCGCCGATGGCGGCGGCGTCATGGGCTACGCGGCGACGTTCGACCGCGAGCCGGACTGCTACGGGGACGTGATCGCGCCCGGGGCCTTCGCCGACTCGCTCGAGAGATGGGGGAAGGTCGGAAAGCCGATACCGCTGCTCTACGGACATAACACCCAGGACCCCAGGTACAACATCGGGGCCGTCACCGAGTAGGAGTGGGACAGGGAGGCGCGGCGGCGCTTCGCCGCGAGCATGAAGTACCGCTTCTCCGGCGGCGAGGGCACGGACTCGGGCGGGATCCCCATCCTGGAGGACAGCATGAGGTTCGTGGACTCCGCGATCAACGATAAGGAGGCGGAGTGGGCGGAGTCCATGCGCCTCACGCGGGAGGACGTGGCGGCCGCCTACCACGTCAACCCGTCCATCGTGTGGAGCAACGATGGGCAGACGTACGCGAGTACGCGAGTGCGCGAGTGCGCCCGGTCCCTGTACGCGGACACGCTCGGGCCGCTGCTCAGGCTCGTGCAGGACGGCATCAGGTCCAAGCTGGTGCCCATGATCGGGGCCGACCCGAGGAGCTACGCCGAGTTCGACATCACGGCGAAGCTGGCGGGGAGCTTCGAGGGGCAGGCGTCGGTGCTCTCCACGAGCACCGGAGGGCCGTGGATGACGCGCAACGAGGCGAGGGCGAGGCAGAACCCGCCGGCCATCGAGGGCGGCGACGAGCTCATCGTGCCCATGAACGTCACCGAGGGGGCTCGCCTCCCCGACGGACACGGACCCGACTCAGGCGTACTCGGCGGGGCCCATGGCCAAGGCCCTCGCCGGCGCGCCTGGGAGACGGCACGGGGCTGGGTCACCCAGGCTGAGGGCACGCCCCGGGGAGGGTGACGTCGAGAGGGTCGAGGAGGCCCTAGAGGCCTTCTACAGGCGGCAGGGGGCGAGCCTGGCCGACGAGGCCCTGCGCATGGGCGCGGAGGACATCGTGCTCTCCGCCGACGCGGACTGGCTCGATGGGCCGCGATGGACCGACGAGCTCTGCGACGACCTCTTCGACGCCATGTCGGGGCTCGCGCCGGCGTGGGCGGCTGATGCGATGACCTCGCTGGGGGCCGATGCCGGCCACCTGGACGAGGACGCCGTCCTCGCGGAGGTCCGCAGGCTCAGCCGCTTCCGCGCGGCCGACATCGTCCGGTCCGCCTCGGAGAGGGTCGTCAGCGACCTGGGCGACCTCGACGAGCTCACACCCAGGGGCGCCATCGAGGCCACGACCAGGAGGCTCATGGCGTCGGGCGCAACGGCAGGTCCATCACGTCTGCCGCCGCCAACGGCGCGACGGTCACGGGCGCGAGGCAGTCCGGCGTCGAGTGCCAGAAGGAGTGGGTGGCGGGGCCCAACGCCAGGGCGACGCACGCGGCCATGAACGGTCAGCGTGTTCCCATCGGCGGAAGGTTCTCCAACCAGGCGAGGTGGCCGGGCGACACGAACCTCAGTGCCGCCGAGTCGTGCGACTGCAACTGCCGCATCGAGATCGTGAGCGGCGAGGGGCGCTCGAAGGACTCGCGCGGCAGCAAGGTGCGGAAGCGCGAGGCGGGCATCCAGAGGGAAACCGACAAGCGTTACAGGGAATACAAGAGCGGCATGAACGAGCTGAGCGAGAGGGACCGCGAGGCGAGGTACCGCAGGGCGATGGGTGAATACGTCGGCTCGTTCACCGTCGAGGGCAAGGTGTCGGCAAAGTACCAAGCCGAGCCGTGGGCCAAGGAGCTTCAGACCACGCAGACGCTTTCCGAACTCGGCCATTCGGTCGAGTTTCTTCCCTCAACGGGTGATGGGAGACATCCGGACGCGATGCTTGATGGTGTCATAACTGACTTTAAGCGTGTCGAGGCTTTTGACCCGGACAGGGTCTTCAAGCTGATACGAAAGGCTGGCTCCCAGGGCGCAGAAATTGTCGTGATAGATCTCTGCCTCGACACCGTTTCGCTTGACGCGGCGCTTGAGAAGGCCGCCAAGGCGGTGAGGCTCGGATTCGTCGAGGAGGGCCACGTCATCGTGCTCGACTGGAACAGCGAGGAGCACGTCATCTAAAGCAAAGGAGCCGGCATCCCTATACCCGGACCTAATGCCCGGGCGGATGCGATCGACTCCAAAGCAAGTATACCCGATTCCCGGGAAAATAGGAGGCAAGATGCCCTACTTCAAGGACGCCGCGACCCCTGCGGACGTCGCCGACGGCGGCGGCACCGTCACGGGCTACGCGGCGACGTTCGACCGCGAGCCGGACTGCTACGGGGACGTGATCGCGCCGAGCGCGGGATCATCCCCGTACGTGGGGAACAGCTCCCAGGCAGACGTCTTCAACGACTACTACGCCAGGCGCATCGCCAGTGAGATGGGCTCCCGCGACCGTCGATGACTCTATGATGACATGATACCAAGGTCATCGTTTGTACCAAGGATAAAAGGCCGTGCGCGAAGGAGACCCGTCTTTAGGATCTAGCACTAGGATTCTTTGACCCGACGACAACGAAACCGAAGCCGACGCCAGCCCCGAGCTGGCGTTTTTGCTGTCTCCGCGAGACTTGACAAGATTTCTCACATGGATCATGTTTCTAGTGCTATAGTGCTATATCAGAGCATGGGAACCGACGGGCGGAAGGGGGCCCGGGATGTCGTACTTCCTCAAGCAGACGAGGAACAAGAAGGGCACGTACCTGCAGATCTACGAGAGCACCTACGACCCCGGCCGCGGCTACGGCACGCACCGCTCGGTGAGGGCCGTCGGCTACGTCCACGAGCTGGAGCAGTCCGGCATCCCCGACCCGGTGGCGCGCCTCAGGGCCGAGGTGGCGGCGATGAACGAGGAGGCCAGGGCGTCGAGGGCGAGGGAGGGGGCGAGGCTCGTCGGCGACTCGACGCCCGAGCGCCACATGGGCCACTTCCCCGTCAAGGCCCTGTACAGGCGGCTCGGCATCCCGGCCGACATCGGGTACCTGCAGATGGCGTCGGGGTTCCGCTTCTCCCTCGACGGGCTCCTGGAGTCGCTCGTCTGCGCGCGCGTCGTCGCCCCGTGCTCGAAGTCGAGGACCTTCCACGACGTCCTGCCGCTGCTCGGGGAGGAGCCGTCCTTCTCGCTCGGCCAGCTCTACGACGGGATCTCCTACCTCGGCCACGAGTACAGGAAGGTCGTCGAGGCCGCGAACGCCCGCGTGGGCGAGCTGTTCGGCCGCGACACGTCACGCTCCTACTTCGACTGCACGAACTTCTACTTCGAGATAGACCGCGAGGACGGCCTGCGCAGGAAGGGGCCCTCCAAGGAGCGGAGGGCTGACCCCATAGTCGGCATGGGGCTCCTGCTCGACGCGAGGTGCGTGCCGATGGGGCTCGAGATATATCCCGGCAACGAGAGCGAGAGGCCGAGGATCCGGGAGGTCATCGGGGCGCTCAAGGAGCGCCACCACATGACCGGCAGGACCGTGCGAGTGGCAGACAAGGGCCTCAACTGCGCGGACAACGTCGCCGACGCCGTGCTGGCGGGCGACGGGTACCTGTTCTCCAAGAGCGTGAGGCGGCTGCCCGCGAGGGAGCTCGCCTGGGTGCTGTCGGAGGAGGGGTGGGAGGACCACCTGGGGAGGGACGGCAGGATCCACCATCGCACGAAGTCCGTGACCGGGGACTTCGAGTACAGGGTGTCGAGGGAGGGCGGCGGGAAGGGGACTGTCGAGCTGCGGGAGCGGAGGGTCGTCACCTTCAGCCCCAGGCTCCGCTCCAAGCAGCTCCGCGAGATCAACCGGCAGGTGGAGAAGGCGAGGAGGCTCAGGCTCGCGGAGGCGAGGAGGTCAGAGTACGGCGACAGCGCCAAGTACGTCACGTTCGTGGCCGTCGACTCCGAGGGCGAGGTCAGGGACGACGAGCGCGTCGTCGCCACGCTCAACCGCAAGGCCATAGGGAGGGCCCGCTCGCTCGCCGGCTACAACATGCTGGTCACGAGCGAGGCCGACATGCCCGAGGCCGAGGTGTACGACACCTACCACCGCCTGTGGCGGATCGAGGAGACGTTCCGGGTCATGAAGTCCGAGCTCGACGCGCGACCCGTCTACCTGCGGAGGCACGACTCGATAGTCGGGCACTTCCTCATCTGCTACGTCGCCGTGCTGCTCGTCCGCCTGCTGCAGGTGCACGTGCTCGGAGACGAGTTCGGCTCCGGACAGCTCTTCGGCTTCATGCGCGGGTTCAGGGCGGTGAGGGTGTCGGAGCGCAGGTACGTCAACATCTCGCGGTCCTCGCCCGTCATCGACAGGCTCAAGGAGGTCACGGGGCTCCCCCTTGACCACTACCACCTCACGAAGGGTGAGTACGACAGGATCCTCGGATACAGGTTCCCCTCCCTCAAGGCCACAGGCCAGGAGGAGTCGAAAGGGTCGATTTAGCACTAGAAATCAAGGTTGTACGCCAAAGTCAGGAAGTATACCCGATTCCCGGGAAAATAGGAGGCAAGATGCCCTACTTCAAGGACGCCGCGACCCCTGCGGACGTCGCCGACGGCGGCGGCACCGTCACGGGCTACGCGGCGACGTTCGACCGCGAGCCGGACTGCTACGGGGACGTGATCGCGCCGAGCGCGGGATCATCCCCGTACGTGGGGAACAGCTCCCAGGCAGACGTCTTCAACGACTACTACGCCAGGCGCATCGCCAGTGAGATGGGCTCCCGCGACCGTCGATGACTCTATGATGACATGATACCAAGGTCATCGTTTGTACCAAGGATAAAAGGCCGTGCGCGAAGGAGAGGGAGATGGAGCACTTACTGGGACAGAATGGGTTCAAGTCAGCCTTCGTAACCCTGCCAACAGAAACGGACGCCCGACGTATTCTTTGTATCCGACTGCGACGAGAAGCTTGTCAAGACGGGGTGAAAGTTCAAGTGCTCCGAAAGCGTCTACCAGAAAACCGTCAAGAACCAAACAAAGAAGGCCTCCGGGACAGGGAACATGCAACCCCAATGCGACAGGGTCCTCATCTCGAACGTGGAGAGCGGCCTGTCGTTCGATGAGATGTACTCGTGGCTCGAGGACCAAGGTGACGAGTTTCCGAAAGTCAGAGAGATGATCATCGTGTCTCGCGACGGCAGGATCAGACATTACGTAAGAGGGAAGCCAGCCGAGTAACCCTGAATTAACCGGGCCCCAGCTGACTTTACGAAGAGCATACCACAACCAGGGGAAGTCCAGGTCATTTCGACAGGGGCATTCCCCCGCTACGCCGCCACAGGCGGGGACCGTGGCGGCGTAGCGGGCAGAGACGGGTTGAAGCTGCCTCGGTTGAGGCACAATGAGCAATGAGACGAGTACACACTTGGGTGAGGAATCGAGGCCTGTGTCCGTCTCCTTCCTGCAGGTCCTGCATAACGTCGGAATCATCCCTGCGCGGGAGCAGTATAGGGACATAAACAAAGGCGTCGTCAGATCGGGATCTTCCCCACGCGCCCCGTGCGGGGCGCGACGGCCAGGTGGCGCCGCCTGTGAGCTACAGCTGAGGTTTCAATCCACGCGTCCCGCACGGGGCGCGACATGCCGAGATACCTGCGCTCCAGACGGATCCCGAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCTGGTACGAGGTAGTCATGTTGCAGTAGCTAGCTTCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCTCTCAGTATCGTCTATCTCGGGATGCGCGACCTCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACTTGACCTGCCACTTGTTGGCCATTGGGAGTTGACTGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCCGGATCGTCCGGCAGCACGCGCACCGCTAGCGCGAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCGCGATTAGCTCATCGCCCATCACGAGATCACTCGGTTTCAATCCACGCGCCCCGCACGGGGCGCGACGGCTGGAGGAGCTACCAGAGCTTTTATCGGTCAAGTTTCAATCCACGCGCCCCGCACGGGGCGCGACTTTGTAGTCTCCGTATCGTAGGAGCACACAATCTCGTTTCAATCCACGCGCCCCGCACGGGGCGCGACCCTCTGCGCTTGTCATGTTATGTATCCTAGCCGTGTTTCAATCCACGCGCCCCGCACGGGGTGCGTACAGCAGGCCCTAGCGACCGGCATTCCATCTCCCACTGACCGCAGTTCCAGGCTCCGCCGACCGCCGCTGCACGCATCACCGACCATGATTGACCCAGTGGGGCGCACTGGGTCGCCCCGTCTCCCGAGAGAGGGGAAGACATGATCAGGCACGGGGAGATCCTCAGGCTCACGGCCCTGGGGATAAGCCAGCGGAGCATAGCCGGCTCCGTGGGATGCTCGAAGACGACGGTGCAGGAGGTGCAGCGTAAGGCGGCGACGCGGCGCCTCGAGTGGCCGCTGTCCGACGAGATGGGGGACGAGGCCATCCGTGCCAGGCCCTGCCCGCCTCAGGACCGCTCCGACGCCAGCAAGGCGGAGATCGACCACGAGTGGGCCCGGAGGGAGATGGGCCGCAGGGGCGTGACGATGACCCTGCTGTGGAGCGAGTACGCCGAGCGCGCCGTCGCCGCCGGTAGGACACCCTACATGTACTCCTCGTTCTGCCACAGGCACCAGCGCTGGGTCGACGCCAACCCCGAGTGCGCGATGCACGTCGAGTGGGTGCCGGGCGAGTGGACGCAGGTCGACTGGGCGGGCGACACCATGAGGGTCTCAGACCCTGACGCCTCGTCTCCGTCGAGGGTTCACGTCTTCGTCGCCTGCCTGCCGTTCTCGGCCCACGTCTACGCGGAGGGCTTCTACCGCATGGACGAGAGGGCTTGGGTGGAGGGCCATGTGCGCGCCTTCGCCGACTTCGGGGGGTCGACCCCGCTCATCGCCCCGGACAACCTCAAGACCGGCGTCGTGAGGAACACCATCGACAAGCTGATAGTCAACGAGCAGTACCGCAGGATGCTCGAGTACCACGGCTCGGCGGCCGTCCCCACCCGCGTGAGGAGGCCACGTGACAAAGGCGGCGTCGAGGGCGCCGTGCTCATCGTCGAGCGAGAGGCGATCGCCGCTTTGAGGGACCGGACCTTCTTCTCGCTCGCCGAGCCCGACCAGGCCCTCCGCGAGCGCGTCGACGCGATCAACGCGAGGCCCTTCCAGAGGAGGGAGGGCAGCAGGGACGAGATGCTTCTCGGCCAGGAGAGGGCATGCCTGCAGCCCCTGCCGCAGGCCCCCTACGAGCTGGTGGAGCGCAAGTCGGCGACGGTGCAGTTCAACTACCACGTTGCCTTCGACGGCAGGTACTACTCGGTGCCGTTCACCCACATCAGGAGGTCCGTCGAGGTTGTCGCCACCCGCTCGACCGTAACCGTATCATCAGACGGCGAACGTCTGTGCCAACATCAGCGCAGCCACGGACCCAAGGGCACCTACGTGACCGACCCCGCGCACATGCCCAGGGCGCACCGCGACTTTGCCGAGTGGAGCGGCGAGCGCTTCCGTAGATGGGCGGCGGAGAAGGGGCCTTCCACGCTCGCCGTCACCGACGTGATACTGCGTTCGCGCCAGGTCGAGCAGCAGTCGTACCGCACCTGCCGCGCCCTGCTGTCGCTCGGTGCATATTGCAGTTTTTTCGGTGTGACGTTCCGCAGTCCGTCGGTGTACCGTTCCATAAGTCATCGGTGTGTGCTTGCATGTGGAACCGGTGCGGACGGGGCGCATGACCGCGTCCACACCGGCGATTTCGCTGTTCTGGGGCTGACTTAGCTGATGTCGCTCATGCGCTTGCGCATCGACTCGCTGCCCTCGACATGGATGACGTACGAGTTATGCACGATTCGGTCAAATGCTAAGTCGTACGTTATGCGAAGTCCGGGCAGGAGGGCCCGCCCGGGCAGGTCCAACGCTCCCGCCAACTTCGCATAACGTGACGATGGCTTCTATGCTGGCGATGTCGTAATCGCCAGCATAGAAGGGAAGTCATGATGCGCGATCTGGATGCGCTTGCCTCGCAAGCGCGAGGCTACCTGGTTGACAAAGGTTACGCCCGGTCGACCATCGCCCACTACGAGGCCGCATGGAAGAGGTTGATGTCGTGGTGCGAGGATGAGGGCATAGGAGGCTACGACCACGATGTCGAGCGACGATTCATAGAAGAGGTCGTCATGGCGAACGCAGACGCGACGAGGTACTTCAGGCTTGATAAAAGTCGCGTCCTGCTCCTCCTGTCCATTGACGAGACCGGCGAGCCCCCCGATAGGGAGGCAAGGCGGCGATTCGTCGTCCCGGCGGGCTTCGACGCCGCCTACATGGCCTATGCCGCAGAGCTCGAGGAGCGCGGACTCAGGGCTTCCACGCGGGAGGGCTACCTCTGCACCGCCCGCAACTTCTGCGAGGGCTGCGGCGCCACGCGCCCTGAACAGCTCGACGCCCGCTCCATCGGCGTCTTCGCGGAGGCGGTCTCGCACTGCGCGCCACAGACCCGCTCGGCCAAGCTCTACGTCGCACGCGACTTCACGCGCTTCCTGGCAAGAGTCGGGGCGTGCGGTCCCGAGGTTGCCGCGGCAGTCCCCCATATCCCAGGCCACAAGCACTCGACCGTGCCATCCGCGTACTCTACGGCCGAGGTGTCGACGATGTTGGAGAGCTTCCCGCGCTCGCTGCGCCCCAGGCGCGACCGGGCGATGATGCTGCTCGCATCCGTCCTCGGCATGCGGGCGGGCGACATCAAGGCCCTGAGGCTGTCAGACATTGACTGGCGCGCGAAGACGGTGTCGTTCGTGCAGCGCAAGACGCAGGTCACGAACACGCTTCACATGCCCGAGGAGGTCTGGCTCGCCGTCGCGGACTACATCAGATGCGAGCGGCCGGACGTCGACGGCGACCGTGTCTTCGTTACCGCATGCGCCCCGTACCACGCCATAGACTCGTCTCACACCTTCCACAGGACGGTCACCCGGGCGTTCGCCGACGCGGGCGTCGAGACCGCCGGCAAACACCACGGCATGCACAGCCTGCGCCACTCGGCAGCAAGCAACATGCTCTCCGGTGGAACGCCCTACCCGACGATATCGTCGGTGCTGGGCCACAGCTCGGCCAACGTTACCAAGCGCTACCTGTCAATCGACGTGGAGTCGCTGCGCCCGCTTGCCCTGGAGGTGCCGTCATGCCTATGAGGATCGAGTTCACGGGAGAGTACGCCGCGCTCATGGGAGGCTACGTCGCCTTCCGCCAGAACCTGGGCTTCGTAATGCCGGAAAGCTCGCAGAGATGGCTGCGGCACATGGCCGATCTCCTGTACACGATGCCCCTCATCTCCGAGGTCATCGACATGGAGAGGGCCGAGGCCATTGCCTCCAGGCGCGAGGGGGAATCCGACGTGACGCGCCAGAGCCGTTTCGTCGTGCTGCGCCAGTTCTGCCTCTACCTCAACCGCATCGGGGTCGGGGCATACGTACCGCCCGCGGGGCAGGTGAGAGCCAGGAGCGAATTCGTCCCGCGCATCGTCAGCGAGCGCGAGATGGCCCGCATAATCGAGGTCGCCGAGGGAAAGGCGCTGCGCTGGCCGCCGATGGTGCTGAAGATCCTCTGGTGCACGGGCATCAGGATCGGCGAGGCGGCGGCGCTGACCGTCGGCGACTTCCATCGCAAAGACCGCTCCCTCTACGTCGCCCACGCAAAGAGCGATCGGTCCCGCATCGTCCCCGTCAGCGAGAGCCTCGCCGTCGACCTAGGGGAATACGTCGACGCACGCGTTCCCGGCGGCGACTCGTGCCGATGGCTCTTCCCGGGGAGGGACCCGGGAAGCCACCGCAGCAAGGTCGCCATCGGCAACCGCCTCCGAGGCATCTACCGGGAGGCCCGGGTGCTCACCGACGAGGGCAGGCCGATCCGCACCCACGACATCCGCCATTCGTTCGCAATCGCGACGCTCGAGAAGATGGTGGAGCAGGGGCGCGACGTGTACGTGACGCTGCCGCTGCTCTCGGCGTTCATGGGCCATGCCAACATCTGCGACACCGAGTACTACTTGAGGTTCCTGCCATCGGCCCACCGGGCGCTGGTCGAGCAGGAGGCCCCGATATCTCACGCCGTGTTCGGGGACGGTGCGCTATGAGGGGATTCGCCCAGCTGCTGAGCGGCTTTCTGCTCGAGTACGTCCCGCGGCGCAGGAGCCTCAGCGAGAACACCGCGAAGAGCTACAGGGATTCGTTCGCCATCCTGCTCAGATGGCTGGCCGACGGGCGGGGAATAGCGCCCGACGACGTGCGGATCGAGGATCTGAGCAGGGAGAACGTCGAGTCGTTCTGCCTTTGGCTGTCGGATGTGAGGGGCGTTTGCGCGGCGACCGTCAACGTCCGGCTGTGCGCCCTCCGCTCGTTTGCCAGCTACGTGAGCTTCACCGAACCGGCCTACCTCGAGTGGGCGTCGGCCTTGCGGGCCGTCGAGTTCTCGAAGTCGCCGTCGGGGGAGGTCGAGTGGCTTCCCGTCGAGGCGGTCAACCTCATCATGGAGAGCGCCAGCTCGGATGCCCGCGAGCACGCCATGCTGGGCCTGCTGTACGACTCCGGCGCCCGTGTCTCCGAGATCGCCAACGCGCGTCGCTGCGACCTGCGCCTCGACGCCCCGGCCACAATAAGGCTCTCCGGGAAGGGGCGCAAGGTCAGGATCGTCCCGCTGTGCGACCAGGTCGCCGGGATGGCGTCGGCGTACCTGGCCGCGACTGCGGGCGCACCGGACTCCCCGCTATTCGTGAACCGCAGCGGGAAGGCCATAGGGCGCGCGGGCATAACGTATGTCCTGAAGAAACACGTCGCCGCAGCGCATGAGGCCGACCCCCTCGTCGTGCCGCCGACGACCCACCCGCACGCGCTGCGCCATTCGAAGGCCGTCCACCTCGTCGAGGCGGACGTCAACATCATATACATCAGGGACTTCATGGGCCATTCCTCTGTCAAGACGACCGAGATCTACGCCAAGATCAGCTCGAAGTCAAGGCAGAAGGCTGTGGAGAAAGCCGCCGCCAATCTGATAATGGGGAGCGCGTATGGGGAGGAGGATAAGTCCGCGATCATGGAATGGCTGAGGAACCTGCTGTAG

Protein sequences of DBSCAN-SWA_4

>NZ_CP012069|1948941:1960782|1949665_1949839_+|WP_157051589.1|head,protease|DBSCAN-SWA
MGYAATFDREPDCYGDVIAPGAFADSLERWGKVGKPIPLLYGHNTQDPRYNIGAVTE
>NZ_CP012069|1948941:1960782|1955952_1957449_+|WP_050340700.1|transposase|DBSCAN-SWA
MIRHGEILRLTALGISQRSIAGSVGCSKTTVQEVQRKAATRRLEWPLSDEMGDEAIRARPCPPQDRSDASKAEIDHEWARREMGRRGVTMTLLWSEYAERAVAAGRTPYMYSSFCHRHQRWVDANPECAMHVEWVPGEWTQVDWAGDTMRVSDPDASSPSRVHVFVACLPFSAHVYAEGFYRMDERAWVEGHVRAFADFGGSTPLIAPDNLKTGVVRNTIDKLIVNEQYRRMLEYHGSAAVPTRVRRPRDKGGVEGAVLIVEREAIAALRDRTFFSLAEPDQALRERVDAINARPFQRREGSRDEMLLGQERACLQPLPQAPYELVERKSATVQFNYHVAFDGRYYSVPFTHIRRSVEVVATRSTVTVSSDGERLCQHQRSHGPKGTYVTDPAHMPRAHRDFAEWSGERFRRWAAEKGPSTLAVTDVILRSRQVEQQSYRTCRALLSLGAYCSFFGVTFRSPSVYRSISHRCVLACGTGADGAHDRVHTGDFAVLGLT
>NZ_CP012069|1948941:1960782|1959795_1960782_+|WP_050340703.1|integrase|DBSCAN-SWA
MRGFAQLLSGFLLEYVPRRRSLSENTAKSYRDSFAILLRWLADGRGIAPDDVRIEDLSRENVESFCLWLSDVRGVCAATVNVRLCALRSFASYVSFTEPAYLEWASALRAVEFSKSPSGEVEWLPVEAVNLIMESASSDAREHAMLGLLYDSGARVSEIANARRCDLRLDAPATIRLSGKGRKVRIVPLCDQVAGMASAYLAATAGAPDSPLFVNRSGKAIGRAGITYVLKKHVAAAHEADPLVVPPTTHPHALRHSKAVHLVEADVNIIYIRDFMGHSSVKTTEIYAKISSKSRQKAVEKAAANLIMGSAYGEEDKSAIMEWLRNLL
>NZ_CP012069|1948941:1960782|1951817_1952045_+|WP_050340698.1|DBSCAN-SWA
MPYFKDAATPADVADGGGTVTGYAATFDREPDCYGDVIAPSAGSSPYVGNSSQADVFNDYYARRIASEMGSRDRR
>NZ_CP012069|1948941:1960782|1952298_1954059_+|WP_050340699.1|transposase|DBSCAN-SWA
MSYFLKQTRNKKGTYLQIYESTYDPGRGYGTHRSVRAVGYVHELEQSGIPDPVARLRAEVAAMNEEARASRAREGARLVGDSTPERHMGHFPVKALYRRLGIPADIGYLQMASGFRFSLDGLLESLVCARVVAPCSKSRTFHDVLPLLGEEPSFSLGQLYDGISYLGHEYRKVVEAANARVGELFGRDTSRSYFDCTNFYFEIDREDGLRRKGPSKERRADPIVGMGLLLDARCVPMGLEIYPGNESERPRIREVIGALKERHHMTGRTVRVADKGLNCADNVADAVLAGDGYLFSKSVRRLPARELAWVLSEEGWEDHLGRDGRIHHRTKSVTGDFEYRVSREGGGKGTVELRERRVVTFSPRLRSKQLREINRQVEKARRLRLAEARRSEYGDSAKYVTFVAVDSEGEVRDDERVVATLNRKAIGRARSLAGYNMLVTSEADMPEAEVYDTYHRLWRIEETFRVMKSELDARPVYLRRHDSIVGHFLICYVAVLLVRLLQVHVLGDEFGSGQLFGFMRGFRAVRVSERRYVNISRSSPVIDRLKEVTGLPLDHYHLTKGEYDRILGYRFPSLKATGQEESKGSI
>NZ_CP012069|1948941:1960782|1951009_1951717_+|WP_050340697.1|DBSCAN-SWA
MAGPNARATHAAMNGQRVPIGGRFSNQARWPGDTNLSAAESCDCNCRIEIVSGEGRSKDSRGSKVRKREAGIQRETDKRYREYKSGMNELSERDREARYRRAMGEYVGSFTVEGKVSAKYQAEPWAKELQTTQTLSELGHSVEFLPSTGDGRHPDAMLDGVITDFKRVEAFDPDRVFKLIRKAGSQGAEIVVIDLCLDTVSLDAALEKAAKAVRLGFVEEGHVIVLDWNSEEHVI
>NZ_CP012069|1948941:1960782|1954622_1954799_+|WP_157051465.1|DBSCAN-SWA
MQPQCDRVLISNVESGLSFDEMYSWLEDQGDEFPKVREMIIVSRDGRIRHYVRGKPAE
>NZ_CP012069|1948941:1960782|1948941_1949355_-|WP_062393124.1|capsid|DBSCAN-SWA
MGYGKGFHALDDDTILRFVGTRWASGKSYSEAIWGDSERVAAWVQDDMAKALARGESWRRLCDELSRRFVDVSERDVMRLVVTEGTYVSRQAQLAELAREGFEEYRVEPVGDERTCEVCSALVGKAFSIDGARVGRC
>NZ_CP012069|1948941:1960782|1950434_1951049_+|WP_157051464.1|DBSCAN-SWA
MAKALAGAPGRRHGAGSPRLRARPGEGDVERVEEALEAFYRRQGASLADEALRMGAEDIVLSADADWLDGPRWTDELCDDLFDAMSGLAPAWAADAMTSLGADAGHLDEDAVLAEVRRLSRFRAADIVRSASERVVSDLGDLDELTPRGAIEATTRRLMASGATAGPSRLPPPTARRSRARGSPASSARRSGWRGPTPGRRTRP
>NZ_CP012069|1948941:1960782|1958848_1959799_+|WP_083443905.1|integrase|DBSCAN-SWA
MPMRIEFTGEYAALMGGYVAFRQNLGFVMPESSQRWLRHMADLLYTMPLISEVIDMERAEAIASRREGESDVTRQSRFVVLRQFCLYLNRIGVGAYVPPAGQVRARSEFVPRIVSEREMARIIEVAEGKALRWPPMVLKILWCTGIRIGEAAALTVGDFHRKDRSLYVAHAKSDRSRIVPVSESLAVDLGEYVDARVPGGDSCRWLFPGRDPGSHRSKVAIGNRLRGIYREARVLTDEGRPIRTHDIRHSFAIATLEKMVEQGRDVYVTLPLLSAFMGHANICDTEYYLRFLPSAHRALVEQEAPISHAVFGDGAL
>NZ_CP012069|1948941:1960782|1954127_1954355_+|WP_050340698.1|DBSCAN-SWA
MPYFKDAATPADVADGGGTVTGYAATFDREPDCYGDVIAPSAGSSPYVGNSSQADVFNDYYARRIASEMGSRDRR
>NZ_CP012069|1948941:1960782|1957664_1958858_+|WP_050340701.1|integrase|DBSCAN-SWA
MMRDLDALASQARGYLVDKGYARSTIAHYEAAWKRLMSWCEDEGIGGYDHDVERRFIEEVVMANADATRYFRLDKSRVLLLLSIDETGEPPDREARRRFVVPAGFDAAYMAYAAELEERGLRASTREGYLCTARNFCEGCGATRPEQLDARSIGVFAEAVSHCAPQTRSAKLYVARDFTRFLARVGACGPEVAAAVPHIPGHKHSTVPSAYSTAEVSTMLESFPRSLRPRRDRAMMLLASVLGMRAGDIKALRLSDIDWRAKTVSFVQRKTQVTNTLHMPEEVWLAVADYIRCERPDVDGDRVFVTACAPYHAIDSSHTFHRTVTRAFADAGVETAGKHHGMHSLRHSAASNMLSGGTPYPTISSVLGHSSANVTKRYLSIDVESLRPLALEVPSCL
>NZ_CP012069|1948941:1960782|1949878_1950517_+|WP_050340695.1|portal|DBSCAN-SWA
MKYRFSGGEGTDSGGIPILEDSMRFVDSAINDKEAEWAESMRLTREDVAAAYHVNPSIVWSNDGQTYASTRVRECARSLYADTLGPLLRLVQDGIRSKLVPMIGADPRSYAEFDITAKLAGSFEGQASVLSTSTGGPWMTRNEARARQNPPAIEGGDELIVPMNVTEGARLPDGHGPDSGVLGGAHGQGPRRRAWETARGWVTQAEGTPRGG

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062393124.1|1948941_1949355_-|capsid	minor capsid protein	NA	NA	NA	NA
WP_157051589.1|1949665_1949839_+|head,protease	HK97 family phage prohead protease	A0A166Y3X8	Gordonia_phage	7.8e-12	56.1
WP_050340695.1|1949878_1950517_+|portal	phage portal protein	A0A222ZFM5	Arthrobacter_phage	1.8e-37	45.8
WP_157051464.1|1950434_1951049_+	hypothetical protein	NA	NA	NA	NA
WP_050340697.1|1951009_1951717_+	hypothetical protein	NA	NA	NA	NA
WP_050340698.1|1951817_1952045_+	hypothetical protein	NA	NA	NA	NA
WP_050340699.1|1952298_1954059_+|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_050340698.1|1954127_1954355_+	hypothetical protein	NA	NA	NA	NA
WP_157051465.1|1954622_1954799_+	hypothetical protein	NA	NA	NA	NA
WP_050340700.1|1955952_1957449_+|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	9.1e-48	30.3
1957522:1957581	attL	NA	NA	NA	NA
WP_050340701.1|1957664_1958858_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_083443905.1|1958848_1959799_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_050340703.1|1959795_1960782_+|integrase	tyrosine-type recombinase/integrase	A0A1B1IQT7	uncultured_Mediterranean_phage	1.1e-09	26.5
1960819:1960912	attR	NA	NA	NA	NA

Sequences of DBSCAN-SWA_5

Nucleotide sequences of DBSCAN-SWA_5

>NZ_CP012069|2222725:2279035|DBSCAN-SWA
GCTACCAATCCATGCTCTTGAGCCAGGACAGGAGATCCTGCCTCTCGCTTTCGTCATAAGCCGCGTCGGGCGCGATGCGCGCGCCACGCTCCTCGATGGCCTTGCGGCGCATCTCCGGATTTGCCCTGGCGTATATCTCGGTGGTGGTTACCGAGACGTGTCCAAGCAGGTCGCGTATGTACACGAGGTTGACGCCGGCTTCCAGCAGGTGCATCGCCCGCGAGTGCCTGAACATGTGCGGGGTTACCTTGGGCGGCACGTTGGCGCCGTCGCTCCGCGCCGCCTCCGAGTATTTCTCCACCACGTACCTGAGTCCCGATCGGCTCAGCTTGCCCTGCCGACCCGCGATGAGCGGCGCGTCGCCCGAAGCCCCCGATTCCCTCACGTGGCGATCGATTATGGCCGACACCTCACGGCCGATGGGGACGACGCGCGACTTGCCTCCCTTGCCGCGCAGCACGACTGCGGAGAAGCCTGCGGAAAGGTCGCACGCCCGGATGTCTATGAGCTCCTGGGCGCGCGCGGCCGACTCGTAGAGCAGCGAAAGCGCGGCGAGGTGCGCGAGGCCCTCCCGAGTCGAGGGGTCCGGTGCGGCGAGCACGGCGCGCATGCCCTCGACGCCGATGTAGCCGACAAGCGGCGGGGGGCAGCGCTTCCTCCCCACGGCCAGCGCCGACGAGCACGCCTCCATCCACACCGGATCCCGCGCCTGGATGTATCGGAAGAGGGAGTGTACCGCCGCGAGCCGATGGTTGCGCGTGGACACGGCGACGCCGCGCGAGCGCTCGAGGTGGTCGAGGAACTCCCCGAGCGCGTCCCCACCGAGGTCCTCCACTCCCAGGGCCTCGACAACCTTCCCGGATCGCCCCGACGCGAAGGAGACGAACTGGACGATGGCGTCACGGTACGACGCGACCGTGTTGGGAGACGCGCCCTTGACGTCGGGCAGGTGGCAGGCGAAGAAGCGGGCCACGTGCCCCTCGAAGCCGTCCATCTCACACCCCTCCCAGGCCGGGGGCCACGTGCGGCGCGTACAGCTCCATGCGCTCGAGGACGCCCGCGCGTCCCTCGTCCGTGAGGCGGAGGTACCATTCCGTCTCCTTGGGCCCGCAGTGGCCCATGTACCGGGACAGGACCGGCAGGGCCGCGCGCACGTCGACCCCCGCGGCGTCCATCCGCGCGAGCGCCCCGACCGCGAACGTGTGCCGCCAGTCATGCAGGCGCGGATAGGCCCCGTCCGCCCTGCGCACGCCTGCGGAATCCAGGAGGGTCCTGTGCCATGTGCCGACGAGCTGGTTCTGCAGCGGGCCGCCCTCCCGCAGAAGACGAGCCCGCCCCCGCCGCCGACGCGGAGTCCCCGGTAGCGTTCGAGCACCTCCGCCATCGATGCCGACATGACGACGAGCCGGGGCTTCCCTCCCTTGCCGAGAACGCTGAGCCGCCTCCCGTCGACGTCGTCCCACCGCAGGCCGGCCGCCTCAGAGAACCTGAGGCCGGTCGAGTAGAGCAGGCGCACGAACGCCGGCATGATGAGGCTCGGCTCGTAGGGGCTGCGCCTCTGGGCGATGCCGGCATCGGCCGCCGAGAACACGGCGGAGGCCTCCTCGTCCGTGTAGATATGGGGCACGAAGTCGCTCTCGAGGCGGACGTCCGCCCTGAAGGAGCCGGCCTCGATGTCCCTCCTCGCGCAGAACCCCGCGAACACGTTCCACAGCCCGACCCTGTTGGCGCGCGTCCGGCACGCCTCGCCGTCCCTGGGGGCGGCCCACTCCGCGAAGGCTGCCTCGTCCATGTCCCGCTCGCCCAGGAACGAGCACAGGCGCTCGCAGGCGCACACGTGGCTTCGCCCGTACGCGTAGCCGCACGCCCTCCTCTCGGCGATGAAGGCGCGCAGGGCGTCCGCCCAACGGCCCCTCATGCGCTCACCACCCGCGGACATGGGGCACCTCCGGCGGGATGGCGGCAAGGCCCTCCTCGTCGACCGACAGGTACGCCTCGGTGGCCGACGTCGAGGCGTGGCCGAGCACCGAGGATATCGTCGGCAGCGGGACACCGGCGGCGAGCAGGCCAGACGCGGCGGAATGGCGCAGGGCATGGCCGCCGTGCCTGCGCCCGGAGCGGTCGACGCCGGCCCGGTCGATGGCGCGCGTCACCATCCGATGGAACGAGGAGCCGCTCTTGTAGGGCGTGTGCGGTGCGTGCGTCGTCAGGATGACGTGCGGGTCGTTCGACCTCGGGCGGGCGTTCCCCGCGTAATCGAGGAGCGGGAACCTCACCCCGTCGACGATGGGCAGTGATAGCCGAAGGCCCGTCTTCGCCTGGACGATCGCGATGCGGCCCGAGCACCAGTCGACGTCGGCGAACCTCAGTGCGGCGACGTCCCCGCATCGCATGCCGTAGTGCGCGAACAGGCTCAGGACGAGCATGTCGCGCTTGCCGGCGGGCGTCGCCACGTCGACGGAGCCGAGGATCAGCGCGACCTCCTCGTCGGTGTACCGCGACGGTAGCGGCGAATAGGCCCTGGCCCTTACGACGGGAAAGGCGTCCCGGCCGCCGAACGCGATGAGCCCCTCCTCGCCCATCCAGTCCAGCGCCTTACGCAGCGAGTAGCCGTCTCGTTTGTTCTCGTGGGGCGATCTCCCCGGCTCTCCCATGTATGCGTGCACGTCGGCCACGGTCAGGTCCCCGATCTTGCGTACCCCGCGCGAGTCGAGGAACAGCAGGAAGCGGCGAACCCGCCAGAGCCTCAGCGCCTTGGTGCTCCCCGCGAGCCCGCTAGACCCCACCAGGGCCGCGTATCCCGCGTAGGCGCCCGCGAACTGCTCGGGCGGGGGCTCGGGGCCGGGGTGCCGCTGATGGCTCTTGAGGTAGGTCCCCGTCTCCTCGAGCTCGAGCAACGTGAGCAGCGGCTTGCGGATCACGCACTGCGCCGGAGTCACGTCGCGCTCGTCGATCGGGAGGTCGAACTGGGCGAGGAGGAAGCGCGCGGCCTCCTCCCTGTTGACCGAGCGTACCCCTTCTCGCTCGCACCACTTGGCGAAATTGCCGAGCACCCAGCGCGCGTTCCTCACCATCTCGTCGCTGTAACCGTCTGACCTCAACCGATCGACGAGGGCGTCGGCAGCGCCCCCTAACATCTTGATGTCCATGCCCTTGCTCCTTTCCACGAGTCGGACACCGTGGGAAGGAGCGTAACTGATTATGTGCGGAATACTAGGTTGTGCACGCCTCTGAACCGGTTAGTCGCGACAGACTGCTCATAACCGAGAGCCGCCGATAACACAACTTATGTGCATTTGCACATAAGTTGTGGGCGCAGCCGTTGCGGAGCCCCTTGACGCTTTGCAGCATGTAGAAGTCGTTCCGCATGCGCCGGTTGTCGAACCTGTCGGCGCAGAACTTGTAGAAGTGGATGAAGCGCCCGAAGGATATGACCTCGATGAGCTCCCATGCCGGGAAGCCGTAGTCGGGCCTCCTCTCCACGAGTCCGCTCGTGTAGGGGCTCGACTTGCCCTTGTCGATCTCGTCGTAGGGATGAGTCCCCAGGTCGTCCTGCTGCTGCAGGAAGTCCCTGACGATTTTGTACCCGTCCGCCCGGCGCTCCTCCATCTTGCCCAGCAGCCTCACCTTCGAGAAGTGCTCGACATCCAGCGTTATGGGCAGCATCTCGTTGCGCAGCCTCATGTCGATGATCGAGAGGTCCGTGAACATGCCGAAGTCGAGGCCGATGTACTTGCCGTCGTTCGGACCGCCCTCGACCCTCGCGAAGTTGGCGCGGTAGGACTTCAGGCGGAAGTAGTTGTTGTTGCTCTTGAGGTATTCCTCGGCGTCTCTCTCGCTGCAGATCCGGAAGCCCACGCCCTCCGACTTGAGGTGGGCAACCTGCTGAGATGGCGTCAGCCACGGCTTTCTCACATTTGCCATGTTGCAGTCTCCTGGCATAAGTCCTCGTAGTTTTCCCATTGTACGCGCGTCGTGACTCGCCTTGGGCGAGAGTCGGCCGTCGCGCTTGTCTTTCGTTCGCCACATCCAGCGAAACGCTATGCGCGCGATAGCCTTCGGCACCCGCAGCAGTGCCCCAAGCGCCCTCATGGCCGGCCTCCCTCCGCTTGGCCTCGGCGAGCATGGCCTCCAGCTGCTCTACGGTGAACGTGAGCCCGCTCGTGTTGGTTTCCCACGGATCTCTCGGGCCCGTCGAAGCCCATGGCGCTCATGTCCACGTCGAAGCTCTCGCCCACCTTGCCGACGGCGGCGCATTTTGCCTCGGGGTCGATGCCTGCGTAGGTGTCGAGCGTCATCGACACGCTCGCGTGTCCGAGGTAGCTCGCCACCGTGCGTACGTCGCAGCCACCCGCGATCATCATGGTGGCGAACATGCGGCGCAGGTCGTGGAACATGCAGGAAAAGCCGTCCATCCTGCAGAAGGCGGAGAAGTCCTTGCCGAGCTGCATGGGGTTGTAGGGACGGCTGTCCGACACCTGAGTGCCCAGGATGCAGGGGTCGCCCACGTCCATACCCATCTCGTCCATAGCACGGCGCGTGTCGGCCCGCATGGCCCTGAGCATCGTCGTGTGGCTGGTGAGGGGGATGGCGTGCGAAGCTGCCGGTCTTGGGCTCCTTGAGGTAGAAGCCGCCCGGGCCGTTGCCGAGAGCGTGGCTCACCGTCATCGCCCCTGCGTCGTCGAAGTCGCTCCAGCGCAGCGCGCAGACCTCGCCGCGGCGCATGCCGGTCGTGAGCGCAAGCTCTATGGACATGCTATTCATCGATTTCTGCGCAGTTCTTATTGAACCAAAACACGTCGTCCCCGCCGAGGCGGGAGGACGCCGCTCGCGAGGCAGCAACGCGTCGCGCACCTTTGCCTGTTTTGCCCCGGGGTCGGGTCGCGACGCCCGCGGCAGTGGACCATCTTGTGGGGCTCGTCGGGACCCCGGCCTCCCCGGACCAGGTCCCAAAGACCTCCCAGGCCTCGCCCGTCCGGCCCCACCGGGCAGCCCGGGGGGTGCCGCCAGCGTCCTCGCGTCCCGGCGCGCACGCGACCCCCGCAGCCCGTCACGGTCCGTCACGGGGTGGTGGCCCAAGGCGCCGCTCGAGGTTCTCGGGCCGGCCGTCCCAGCCCGTGCCACTCACCAGAAACCCCGAAGGGCCTAAAATGAACAAGATACGATAAGGAGAATTGACCATGGAACTCTACGACGCGTCTGAGCTTTATCCTGGCTTCGAGTACCCCGCAGGCATCAAGAGGGTTGTCGAACTTGGACTCACATACCTGGGCTGGTGGTGGATCCTGGAAGCATGCTTCGCAGGTGACTATACACGCAATATGGCGGGGCGCTATCCCGATCGCAGGCTCATTCCCTTTGCCAAGCGTGAGGACTGCGATGACGTGGCCTGCTTCGAGGTTGGTAGGCCCGGAAAGGTAACCATAATCCACGACTTCGCCAATCCGGGTTGGGAGCAGCGTGAGGAGTACGGCGACTTCTGGTCGTGGTTCGAGGCGGCCGTGCTCGACATGATTGCCCGGGAACGCGAGGAGGAGGCGGAGAATGGACTCTAAGCTGACACATATCAGCAAGGAGATCTCCTATGCACTGAGGCATGCTCCCTGGGAGTACGAGCTCGAGCTTGACGAGCAGGGCTTCGTGCCCATCGAGCAGCTCCTCCAGGCGATGAACGAAGGCCGAGACGAGGGCGACGCCGTTGCCCTCGCCGACCTCGAGCGGATAGTCGCCGAGTCAGACAAGCAGCGACACGAGATCGACGGAGACAGAATCCGAGCCCTGTACGGACACTCCGTGCCCAAGAGGATCGAGAGGCTGGCAGCCGAGCCTCCAGCTGTCCTGTATCACGGGACCTCTCACGAAGCCGCACAAAGGATTCTCGCCGAGGGGCTCAGGCCCATGGGCAGGCAGTACGTACACCTCTCTTGCGACGTCGAGACCGCCGAGGCCGTCGGTAGGCGGCGCGACAGGAGCCCGATAATCCTCTCCATTGATACCAAGAGGGCAGACGGAGATGGGGTCGCGTTCTATCGCGGCAACGACAAGGTTTGGCTGGCAGACTCAATACCTGCGGATTGCATCTCCGTGAGGAAGGGCAGCCCCTATGGCCGCCCTTCCCGTCAGCTCACGGCTGAGCCAGCAGACCAGAGGCCACGCATCCCCTCCTCAGGCCATACCGCTCGGCCAGAGGCCACGCATCAGGCGTAGACAAGGATAGGGAGGGCTTGGAGGCGATCCCCGCCACGAAGCGCCCTACCCTCAGAGCGCATCGCCCCCTCGGGGGCGACTGCGGACGACCTTGGTCTTTGCATCCTCGCGCTCAGGTTGCACCAGGCACCGACGATAGCGCCCACGGCGAGCACGGCAAGGGCGCCGAGCACGGCGGCCGGTACGTTCGCATCACCCGTCCTGGGGATGCCGAGCGTCGGCGTTTCGGAAGGAGGCGTCTTCTCTTCGGGTTCCGTAAACATAGACCGTCGTCGGCCCCTCAATGAGCGTGCGAGAGCTCATGGGGAAGCTCCTTGCCCACAAGGAGGGATCGGGCACCATCGAGCCCTCCACGATGCGGGGCTACCGCGCCGAGGCGAGGCAGATGGACTCCTGCATCGGAAACGTCCGCCTGGCGAACCTCTCCGTGGAGGACGCGTCCTCCTGGATGCGCGACATGGGCGCCGACGGCTACGCCCCCCAAGAGCCGCCCCAAGGCGTTCCGCCAGCTCAGGCAGACGCTCAAGTGGGCCGTCACCCAGAGCCTCGCCTCCAAGAGTCCCTGCGACTCCCGCAGGCCGCCCAAGCGCGTGAAGACGCCGACAGCCTCCCGGCCGTAACGACCGCACCCGCATGATGCGCCTGGCAGTGGCAGCCCGGCCCTTTCCACTCGGCATGGCCATAGAGCTCGCCCTCACGACGGGTATGAGGCGCAGCGAGGTCCGTGCCCTCAGGCGGAGCGACCTCAACGACGACGGGACCATCACGGTCTCCCACACTGGGCGACGCCGAGGAAGGCTTCTACCTCAAGGAGCCCAAGACCCAGAGCTTCGCCCGGACGATACCCCTCGCCAGGCGCATGCTCCAAGCCCTCAGGACCATGCGGGCAGGATGGCTCCGCGCCGCCGAATTCGGCCTATTGGACCCCTTCGTCCTCGGCGCGCAGGGGCCGGAGAGCCGCCCCCACAACCCCACCCAGCTCGGCAAGGACTTCGTCGCCCTCTGCAAGATGAACGGCTTTCACTGCACCTTCCACGACCTGCGCAACGCCCTCGCCACGATGATGATCGCAGTGGTCGTCAACGTCCGCACGGTCGCAAGCTGCCTGGGCCACGCGAGCGTGTCCGCGACCCTCAACATCGACGCCGACGTGGACATGGCCGCCGCCTCTCCCATCAAGTGCGATCTCTTCGGTAACGAGCCCGCTTCGCAGCCGCAGGGCCTCGCCTTCGCGGTGGGGCAGCTACATACCGGCCTAGGCCGCGAGCATGCGCTCGACCGTATCGGGATCGAGCCCCAGCGACGCTACGCCGGGGGCCCGCCGGCTTTCGGTCGTCAATGGGTCGAGCGCGCCTTCACCCTGCGCTACCCCTGCGCCGCGAGCGCGCGCTCGATCTCGCTGGCGTCAACCCCCGCCGACGCGGCAGCGTCCTGCACGCTCACGAGGCCGTCGCGCACGAACCCGCAGATCGTCTCGAGCTTGCCCTTAGCCTCACCCTTGGCCTCGCCCTCCGCACGGATCTCCTCTATGACGCTTCCCATGGCCATCCTGCCCACCTCCGTCTCCCTGAGCCTGCGCTTCTCACTCGAGGTCTCCGGGAAGCGCGCGTCATCGTACGCGTCGCCCTCCACGAAGAGCCTCATGAGGGCGGCGACCTCGCTGCCGTCCCTCGCCAGGGCGTTCACGTACACCTCCGCAAGGCCGTTGTCGCCCGCCTCGCCCGTCTCCCGGAGGACCCTGTCCATATGGTACAGCGAGCGGGCGGCCCCAAAGGGGTCGAACTCGCAGACGATCGCCACGCAGACGTCCGGGACGTCCTCGAAGCGATCACCCGGCCCCGTCCTGTCCGCCGTCACGAGCGACGCGTAGTAGCGCGCCCGCCTCTGGAGGTCGCCCTCGTCCACCCGCTGCACCTCCACGTCCACGAACCCGCCGCCCGAGAGCTCGCAGAGGGCATCGAGGACCGCCGAGCGCCCGTGGGGGTTCGTGACGGCGGACTGCGGGGTGCACTCCACGACGGTGAGCCCCGGGTCCTCGAGCAGCACCCTCAGCACCTCCTCGCAGAAGTCCTTGCTTTGCGCCATCACCCGAAACATCAGGTCGTCTATGGGCCTCAGGGCGCCCATGTCAAGCCTCGTCTGCACCATCCGACCGCCCCCCTTCCGTTTGCCGCCTCTCCTTTCACCCATCATAGCACAGTGAAAGAACAATCGTTCTTATAAGTTCATGGAAATACACCCTCCCTCCAAAGACAGAACGCACACTTGGGGGGTGGGCGCCGGGTAGGCCACGCCCAGCAGGTCATGGGGCCGCCCTCGGGTGGCGGGACGGCTCTGCGGCTGCCGGCCCGCTCGCCCGGCGGCCCCCCGGCTCCCTGCCACCGACTTTCGGCACGGGCGCCCTGGCGCCATTCCTGGGTTGCCGTGGCCGTCCTCACGTCCCATCCCCCAATCACGTGTGGTCTGTGTGCACCCATCCTCAAGTTTCTCTCCTCCACTGTTGACATGGTGACGCCCCTCGTCTCCCCCGATGCCGCCAGCAAGTTGGCACGACGAGGGGACGCGTGGAAATGCCTGGCACGGGGTTGCGAGGTGACAAAGGTGCCGGACATGTCGACGGTGGTCTAACGGAAAGTCGTGGAAATGCGCCGGTACCTCGCAAGCAATGCCCAGATGTTCGAACGCATAAACGCAATGGAGGTCAGGCAGCTCGAGTACCAGAAGACGAGCGCTTCGAGCGAGTCTTCGACGACATGGAGGCCCACGAGGCACCGAGGCAGAAGGTCTTCTTCGAGGGCCAGGTCTTTGACGCGTTCGAGCTCCTGGTGTCGCTGGTGCAGCATGCCAAGGAGTCCATAGTCCTCATCGACGGCCACACCGATGCGGACACCCTCAACACACTCGCCAAGAAGAACGGGGGCGTGGCGTCCACACTCTAGACCCACCCCAAGGCGAGGCTCACCACCAGGGACGTCGAGACCTTCAACACCCAGTGCCCCAAGCTCACGGTCAGACATGCCGAGTCATTTCATGACCGCTTCATGATACTGGACGATATGGGAGCCTACCTCGTGGACGCACCCCTTGAAGACGCGGGGAAGAAGGGCTTCGGCATCACGAGGATTGAAGGCCTCGAGACAGTCCGAGCCATCCTCGACAGCTTGGACCCCGGCGAGGAAGTAGTTCCTGATGAGGACACCAAGGCATTGGGTGGCAGGGAAAACCGGATAGACCGATAGGAGGCATGAGAAGGAAGCACCGCATCCCATGTGCGGCGCCCGCCCGTATGACGAGAAGGACTCATGGTCTAAGCAAGGCTATCAAGAGTTTTCAACACCGTGCGGAGGGAAGGCGGCGGCCGTACACGAGCCAAAGCACCACCGCCAAAGGGGCAGCCAGCACGCAGAACACAGGAGTCAGCGCATCGGCCGCACCCCACGCCAGCTCCTCGTGCCAACGCCTCCTCACTTCAGCATCTCGTTCATGCGCCGCCACCTGGCCGCGTAGTTCGCGCCCAAGCGGCATTTGCGTTCCTCGCCGTTGCCATAGTCGCCGCAGGTGACCGCCTCAGGCAACTCGAGAACAGGGCGAGGCCGTTGTCGAGAGACCAAGGCTCGGGGCAGTCCCTTGGAGTTTGACAAGACTGTAATGGGGGATGCGGCCCGACGAGATACGCGGCCCCTCGGCCGCCCCGAGGCAGGACTCCTCCATAGGCACGACCAGGGCAGGGTTGCGATCGGCAAGTTCATGAAAATATCCGGCACGCGCCCGGAGCAGCACGGAGGCACCGGAGTCAAAAGCGACCCCGGTCACGGGAGCCCGACATGCGCGGGAGGAACCTAGGGTCGGCGGCAGGAGCGTGGGCTAGGTAGCGGGGCACCTCAGAGACTGCGACGAGGGCGAGAGGCTGGGGTCGAGACGCGCCACAGGAGGTGGGCAAGTCGCGCGCTCCTGCCCTCAACGTCACACCGCCCCTCGCACGGGGAGGCAACGGGGACCCCTGGTCGATGACCGGCGCAAATGTGGAGTTCAGGACGGCGGTGGAGGCGGAGCCCGACCCATTGGCCCGACATACCGGGGAAATCGACCAGGGATTGGACTATCATGAGGGGATGACATCCAGTCTGCGTCGTGTGTCCGTGGACTTGGGCCGCCCCTCTCTATGGCAGATTCTGCAATCGAGCGAGTCTTGATCCAAGTTTCCCACCGCAGCCCCCTCGCTTGATTCAGGTCGACGTTAACAGCCTCACCGGACGACGTGCGGGTGCTCGACCGCTCCTACACCGACGGCGGCTGGTGGCTCTTCGACCATAGGATCAACCTCACCGACGAGGTCTTCGCGCTCGCGGGCGAGGAGGCGCCGCGCAGGTGGATGCGCGTCAGGGACGTCGAGGCCCTGCTCGAGAAGGGAAAGGATCCGCTGGACCTGAGACACCGCACGGGGGACGTTCATCTCGGTTGATAATCCGCAGTTGTTGATACCGGCCTGAGACACCGCACGGGGGGACGTTCAACCCAACAGCCCCGTTTTGTCAACTGAGACGGGTCAAGCGATATCAGGGTACTGCGGAGGTCAGGAGAAGAGCGCAGAAAGTATAGATGAGAGGTTTAGGCATGGGATTAACTTGGATTAACAACGACAGTTTTATCACTAAAGAGCTCTATGCACCATTTGTAGTTGAAAAAGATAGCGACTATCTGCCCGACTTATCCAGCCGATACAACATTTTGCTCAACTCTCTGTTAGACCACCGTTGACACGGCCAGCTTATCCTCCCAGTAGGACCAGAACGGCTGCGGCTCCCTCGCGAGGGCGAACCGCGTGTTGTCGTAGCTCCCCGTCGCCGCCTGGCCCGACAGGGTGTCCGCCCTGTCGGCGTCCGACCTCCTCGTCTGCTCGTCCCACAGGAACCAGTCGAGGTAGTGGCCGAGCCTCCTCGTCGAGACCCCCCGAGGCGCGCCAGGAAGCCCTCGGGCCTCGCGTGCATCGCGTCCGCCATGCCGAGCTCGCCGCGCACGGCCTCCCGCGCGGGCGTCGCGTCGTGGCGCGACACGCCGAGCCTGGGGAGCACCCGGGCGTACCCACGGAGGCCGTCGGTCGAGACGGACGTTCCCTCGCCCACGGCCCCCAGGGCCGAGGCCGTACGCCTCGTCGGTCGGCCGGCCCCGGTCCGCGACCTCGCAGAACTCGTCGCCGAGGTCGCCCCCCGCAGACCACGCACACCTTGAGGTTCGATATGCCGCGCTCGCGCACGGCGCCGCCGCAGCGGTGCGGCTCCCGTGGCATCCCCGCCGCCGACCCGGGCCGCCTGCCGGCCGGCGACTCGTCGAGGTACGTGCCGTCGACCTGGCAGGAGACGGTGGGCCCGCTCCCGGACGGCGCAAGGGCGCGGCCCATGACCTCGCAGAGCCTCATTCGCATGAACCAGGACGTGCCCGGGCACACCCCGCAGGCCCTCGCGCACTCCCCGGGCGTCCCGCCCGCGCACGCGTGCTCGACGTAGCTCGCCCAGACGTCCTCCCTGAGCTCGGGGTACCCGAGCAGGCCCATGGTCTTGCGCGAGAGGGTGCGGCCGCAGGACCCGCGGGCCCACCTCTGCGACCCGTCCCTGTCATGCCCCTTGCGCACGAGGTGCGTCCCGCCGCACCTGGGGCACGCGTCCGGCTCCCCGCCCGCCTCGCCGAGCTCGGCGAGCACCTGCGCGCGCAGAAGCCCTATGAGCCTCCTCCTCTCGTCGACGCCCAGCCTCCTCGCCTCTTGCAGTATCATGCCAGGCATCCCGCGTCTCCCTTCGACGTGTTTTCTCGCTGACAACATCGTAGCGGAGACGCGAGGCGTCGTCATGTCAACGGTGGTCTAACAGAGAGTTGCTCAAACGGGCACAAAGGTCCGGAGCAGATGAGGAGAGTACCGAGATAATCACCAGATACAAGCAGAAGATCCTTGAGGCACTTAGCAATTATAACAAAGCAGATATTGCGCAATGCTACACAATAATAGAGGGGCTAATTAAAGACATCGGCCATAATCCCCTTGCGGTCGATACGGTAAAGCAATCGAGCGCTTTTCCCGGGAAGCTTGGCAGTGAGGTTCAATTCTTCAGGGGAAGAATTGGCAATCCATCTTGCTCTTATGTGGCGAAAGACATGCTTCATTTGCCGAAAAGCCGAAGAGTGAAAACCGGTAACTATAGGTTCAGCATCCCCGGCAATCCGAGCTTTTACCTTGCAAACTCATCATACGGATGTTGGATTGAGATTGGCTTTCCTTCCTACATCGAGTTCAACGTCGCTCCCGTTGTTCTAGATGAAACACAGAAAGTTTTCAATCTTGCAGTTTCAGTAAGGGACTTCGATTCGATGAATGAATTCGAAAATGACAGGGTTCATTGTTGGCTAAAACTACTCATGTTAAAGATCGCCACGTCGTATCGAATCAACGAAGACAAGAGAACATTCAAATCCGAGTATATTATCTCCCAAGCAGTAATGATCTCTTGCAAAAGAATGGGATATGATGGTGTTGCATATTTTTCCAGAAGAGTGTCAGACGAAGCGTTTGCTTTGTGTGCCATCAATCTCGCCTTGTTTGTTGATTATGATGATGGTGAGTATTCCCCTCTCATCAAGCATATAAAGATGGATAGACCCCTGAACTATTTCGTATTCAAACAGTTGTGTCAATCATTGAAATACGGAGAGTGTAACTCAAGCTTAAGAACAGTAAACAACCCGTATATAACGAACATAGGAGACTACAGCAAGCAATACCCTTATAGAGAGACGGAGTTTTTCGAGTTCGATAAATTTCTGTTCGCTTCATGGAAAAAGGATGAATCTCCTTGGGGTGTGCCTGTTGAGTAACGCATAGAATCAGAAGTACTCGTTTCTTTGTCATACGTTTCTTTAGACGATATGACCCGAACTGAGGGGGTGGAGCCTATTCCGGGTTGGGGCCCCAAGGGAATCTCCCGTGAGCCGGAATGGTTCCGTTGCGGCAGAGGGGCGCCGAGGTGAAGCCATCATGTGCAGAGGTGACAGAGAGGATGTTCTCGCGCGCTAGGCTCAAGGAGCAGTCCTACGACTCGACACTCTCGGTGCTCAGGCTGTCCAAGAAGTACGGCGACGGGCGCCTTGAGGCGGCGTGCACGCACGCGCTGCCGAAGAGTGCATCGCCGAGGTACCGGAACCTGAAAGCGACCCTCGACTCCAATCTCGACGAGGAGCCGAAGGTCCCGGAGGAGGAGACGCCCGTCGTCCCGACGGGCACGTGCGCGGGGCGGAATACTACAAGGAGCTGGGGTGATCGCGATGATCGACGAGGGGATGAGACGCAAGCTGCGCGAGATGGGCATGGGTGAGATAGTGGAAGCCCTTGGCCTGCAGGAGGCTGACCGCACCTGCATGGGGATGCCCCTCAACGAGCGCGTGCGTATGATGGTTGACCACGCCCACGAGGGCAAGCACTCCGCGAGCGTGAGGAGGCTCATGCAGAGGGCCAGGCTGCGGTTTTTCGACGCCGACCCCAGCGAGATGATCTACGACGGCCGCTGCATCGACGGGGTCCTGATCCGAGAGGCGCTCACCTGACAGTTCATGGACAGAGCGCCCAACGTGATAATCGAGGGATGTACGGGCACCGGGAATTATGCTGAGAAACGGATTATGTCGGGGAACGGGCTGCCGCCGCAGGTCATTCGCTCGCGGCAGCCGCGTCCCTTTGCATAACCGAAGAATCCTCCTAGCGTTGCATCACCTGCTTTTTCGACAATGATAGGAGGACTTATGGCAGATCACACCAACTTGGAGGCCCTGATCTCCGATACCCTGGTCGAGATGAGGAGGCTCGGCTATTCCGAGAACACCATAACCGGGCTCAGGAGGATGTTCGCGGCGCTCTCGAGGTACGCCGTCTCGCAGGGACGCAAAGAGTCCGGCGAAGAGCTCGCGATTCGGTTCCCCGATGCGAAGTTCGGCGTCGAGCTCACCCAGCCCTGCCAGGCAAACCCCGGCGGGAGCTACCTCAAGGCCTGGCTACGGGCGATGCGCGTTCTGCTCGAGATGGGAGAATGCGGCCGCGTCTGCAAGCGCATGCCCGGCGATCTCGTCCGAACCGAGCTGCCTGAGGAATCGCGGTCGCTGCCGGGCCCGTCCGACGATGCCAGCCGGCGGGCTGGGCACTCCGAGTCGACCATCTACTCGCGCAACGGCCGCATCAAGCACTTCTTGATCTTTCTGGCAGGCAACGGCGGGACCGACGCCTCGTGCATTACCGAGAGCTCGGCGCACGACTACATCCTCACGAAGTCGTCTAACCACGCCAAGTCGGTGAGGGCGATCCTCACTGCGCTCCGGTGCCTCCCGCGCCACCCGCGCCTGGGGGCACGGCGGGACGCGACCTCTCGCCGAGCGTGCCGAATCCCAAGCCCTGCTATGCCCCCGAGCTTCCCTCCACCTGGACGGCGGACGAGGTGTCGAGGCTGATGAACGGCATCGATCGCGGCAATCCCACGGGGAAGCGCGACTACGCCATGCTGCTCATGGTCGCGAGGCTGGGGCTTCGGGCCTCAGACATAAAGTCGATGCTCATCTCCGACGTCGGCTGGTCGGCGAGGACGATATCGATCACACAGCACAAGACTGGCGTACCGCTGGAGCTACCGCTGCTCGACGACATCGGCTGGGCGGTGATCGACTACCTGCGGGAAGGGCGCCCGAAGGCTGCCACGTGCCCGCAGCTGTTCGTTCGCCAGGTGGCGCCCTTCGACGCGTTCGGCGCAACCGCCAACCTCACCAACATACTCATAAGGCGTGCGCGCGGCGCCGGCATCAGGGCCCCGCGCGACCACAAGACGCTCCACTCCCTGCGCCATGCGTTGGCCAAGCGGCTCCCGGGGCAGGAGGTCCCGATAGAGGACATATCCCGCATACTCGGGCACGTCGACAGGCGCACTACCAGCATCTACCTCCGCATGGACGTCGACTCCCTGTCCGCATGCGCGCTCGATCCGGCGGTGATCGCATGACTTTCGCCAAGATCACGTCCGCCTATGTCGCGGAGAGGAGGGCGGTGGGCCTCAAGTGCGAGAGGGACGACAGGGTCATGGCGAGGATCGCCGCCTTGCACGGCGAGCTCGGCTGCCCCGAGGACGAGTTGCCGAGGGCGCTCGTCGAGGCCTGGATCGCGAAGCGCCCCGGGGAGTCGGAGACGACCGGGCTGCGCCGGATCGGACAGGTGCGTGGGCTCGCCAACTACATGATGCGCGCAGGCTACGACGCCTACGTCGCACCCGGGAGGCGGGGCCGTGCCGACCGCGGCACCTACGAGCCGCACATCTTCACAGACGCCGAGCTCGCATCGCTGTTTTCCACAGCTGAGGCTATCGCGGGCGGCGATCCGGCCAGCCGGCGCGCGCAGGCCGCGAGGCTGCTCAGACTGCTCTATTCCTCCGGCCTCCGATGCGGGGAGGCATGCTCGCTGGCCAAGGGCGACGTCGACCTGGAGGCGGGCATCCCGGCGATCCGCCACGCCAAGAACGGCAAGGGCCGGCTCGTCCCACTGCATCCCTCCATGACCCATATGCTTCGCATATTCCACGACACGGCCGCTTTGCGGCATCCCCAATACGGGGGTCATGGGCTGTTCTGGTCCCTGCCCGAGGGCAGGCCGATGACCACGGGCTTCGTGTACCGTTTCTTCAGGAAGGCGCTGTGGGCGGCGGGCATATCGCATGGTGGCCGGGGCAGGGGGCCGCGCGTCCGTGACCTCCGCCTCGCGTTCGCTTGCCATAGGCTGAGGAACTGGGTCAGGGAAGGGGCCGACGCCGATGCCATGATGCCGGTGCTCGCCGCCCACGTGGGCCACGCCGACATCCGCCGCGCAGAATACTACCTCCGCCCCGCCGCGGAGATCTGTCCGGGCATGGTCGCACAGGTCGAGCGCGAGTGCGGATGGGTGGTGCCGTCATGACCGACGCCGACCTCGCATGCCACGCCACCGACTGTCTGGGACGCCACCCGGCCGGCGCGACCCCGGTCCCAACACGATAGCCTCGTACCGCGACGCGTCCGGGCTGCCCGTCGACTACTTCGGCGATCATGGCAAGGAGCCGGAGTCGACGTCGACGCCCGATCCGGGCAGACACGCGGTCAGGGGGTTCCTCGAGTGGCCTGCGGCGCGCGGGAACTCCGACGGCACGGCCGACCGGCGACCTCGCGCGACAGGGGCGCTCGCGGGATGCGCGAGGGGGGAGGGCCCCGCCCGGCTCCTGCAGTACCAGCAGGTCCTCGCCATGAGGCAGAGGAAGGGGAAATCTGACGCGATGGTCACGCCAGGCAGGGACGGGCTTGCCGCCATCCTCAGGGACCCTGGGATGTCGACCTCCAGGGGGCGCCGCGACACGGCGCTGCTCACCGTGCCGTGCGACAGCGCCGCGCGCGTGTCCGAGCTCTGCGGGATCACCCTTCGAGACCTGAGGTTAGACGACCCCGCCGTCGTGACACTGCGCGGTAAGGGCCGCAAGGTCAGGACCGTGCCACTGATGCATGCGACTGCCGGCTTGCTAAGGGAATACGTATCGGAGGCCTATCCCGGCCTCGGTCCCAGGGACCTCGACAAACCTCTCTTCCCGAACCCAAGAGGCGACCATCTGACCAGGGCCGGTGTCGCCGACATCCTAGCCAGGCATGCAGACGGGGCGAGGAAGTCCGGTGCCGACATCCCCGAGGGTGTGTCGCCCCACTCGTTCCGGCATCAGAGGGCGATCGATCTGCTGGAGTCGGGCGTGAACCTCGTCTACATAAGGGATCTTCTCGGCCACAGGAGCGTCACGACCACCGAGATCTACGCGACCGTGAGCACGGCGAGGAAGCGCGAACTGCTGGAGAAGGCCGCAACGGCACCCAGGGTCGGGGAATACCCCGACTGGACAGCCGACAAAGACCTCATGGCCTGGCTCAAAGCTCTCTGCTGATATGGGGTTATGCAAAGGGACGCGGCTGCCGCGAGCGAATGACCTGCGGCGGCAGCCCGTTCCCCGACATAATCCGTTTCTCAGCATAATTCCCGTTATGGAAAGTTTTCCATAACGGGAAGAGCTACCTCGCCTGCCGCATGGTCAAGCAGGCCTGCAGGATGCGCAGAAGCGCGCGCTACATAAGGCTGCCTGACCTGCTGATGGAGCGCGACGAGCTTGCCGTCACCGAGCACTCCGACGCCAAGATGCTGAGGAAGTACGCCCGCTACGGGCTACCCGTGATCGACGAGTGGCTCACGGAGGACGTCGACGACGTGGCCATATGATTCCTGCTGGAGCTGGTGGAGCGCCGCTACACGGACCGGTCAACGGCCCTCTGCACCCAGTCCGACGACCTCGTGGCGGCCATCGACGCCGCGGCGGGCCACGGGCGCGCCAGGCCCCGGGGGCCACCGGGCGGGCCGCCACCTCTGGGTCCGGGGCCGCCTGCGAGGCGGCGAGGAGGCCCTCGATGGCGGGCGCGTGCCCGACGTCGCGGCCGGCGAGCGCGACGGGGGCGGGGCCGGCCCGGCGGCCTACGAACGCCTCGCCCGCAAGGGGGCGAGGCTCCGTGTCGCCCGGCCCGGGATCTCTCGCGGCGCGCGCCGCCGCCGGCCGCAGGTGCTCCCCGGCGGGCTCGCCACTGGACGGGTGGGGCACGCGTGGCACGCCCAGGCAGGCCGGGCACCTCGCCGAGCGCCCCGGGGCCGGGTGCGCGGGCGGGCGCGCGCCCAGCCGTCAGTCGATGCGCCAGGCGAGGTTCCCCGCGGCGTCCCCCCGGCCGTGCGGCCCGGGAAGGTGCCGCGGCGGCGGGTCGCCCGACCCGCGAGCTTGTCCAGCTCGCGAGGGCGGGGCCGCCTGGGACCGCCGGGCCCGTCCTCCTGCCGCCCGACGCGGGCGGCGCGAGGCTGCTCTTCCAGGTCATCTCGGAGTCCCACGGGAGGCAGTCGCTCGTGACAACCACCAACCCGGGGTCCGGCAGATGGGGGGCCGCCCTCGGCGACGACCGGACGGCCGTGGCGGCCGTCGGCCGCGTCTGCCACCACGGGAGGCTGCCCCGGTCCGGGGGCGAGTCGCGCCGCGCCGGGCATGCGCCCGTGTCGGGGAAGGGGGCGGCGCGTCGGCGGCGGGGGATGGCGTCGTGCCCCGGGGCACCCGTGGCGACGTCGCCGCCCCCGGTGACCCCGGACGCGCGTCGCGTCACGTGTCCGACGACGCCATGCCCTCGGCAAGGTGCGACGGACTCCCCCGTGACGGGACAGTCGACCTGTGGATGGAGGAGGTGCGCCGTGACGGCCCCGATGCGCTGGGGTTCGTCTGGTGCGAGGCCGTCCTCCGACCGGATGGCGAGCCCCCGGGGCCATCGGACTGGCGACCCTCCCGTCTCGGTCGGGCGACCAGGACGGGAGGCACCGGATTTGGGCGACAGACGCCCAAATCCGGTGCGAACTCTGCTCAAATCCTGGTGCGATTTTTGCTCAATTCTAACAGTCTAGATAACGGGTGATAAATCTGCTAGGTCGAGCTGTGGAAACGCGCGTCGGTCATGAGCAAATGGCGGACCACCCTTTCCGTCTCGGGCCATCTGTCCCGAGCCTGGTTGACCCTGAACAGGTAGACGTACCAGTTCAGGTAGCTCTGCAGGTTCTTCGGGTCCATGCCCGTGAACCGCCACAGATAGCGCTTCAGCCACGAGCACAGGTTGTTGACGAGCGACATGCGCTCCAGGTACACCGGGTCGCCGACGTCGGCCCTGTAGGCTTCGTGGGTTCCCTTCACGGCTCTCACCAGGGAGTCGTGCGACTTCTCCTTGTCTCCGACGATGGTCGAGCCCTCCGCTATGTGGGATTGAAGCCCATCCCTGATGCGCTTGGCCGAGGGCTTGCCGTGCCCGCACACCACCGCGACCGGGTTCTTGTGCACGTCGATCGCGACGGCTATGCAGAGCTTCTGCTTGGACAGGCCCCGCTTCCGCGCCTCGCCGTAGCCGTGCGCGAGGTCCGTGTCGTTGACGTAGGTCTCGTCGATCCAGACCCTGTCCTTGAGCACGATGCGCTCCTGGCAGCCGTCGACCGCCGCGAAGATGCGGTGGCGCCACTCCCAGGCGGTCTGGTGCGTCACCCGGCATGTCTCCGCCGCCGCGTCCAGCGGCACGTTGAACCTCATGAGGTTGACGAAGCCGACCCAGGTCGCAAGCTCTTTCCTGCAGTGCTCGAGCACGGTTCCCGTGAGCGAGTTGAACCGCGTACCGCAGCTCTCGCACCGGTACCTCTGCAGCCCCGACTCGCTCCAGCCGTCCCTGGACGGCTCTGCCGCGCCGCAGCTCGGGCACGCGGGGTCCGGTCGGTAGAGTGCGGCGGCCTCGGCGTAGGTGCCGAATCCGTACTCGTCGCGGCAGCGCCGCTCGTCCACCGCCGCGGCGAGCTCGGTGAACTCGTCGTCAGTCATGGCGGCCACGCGCGCCGCGCAGGCGTTCTTCTTGGGCATGGCGATTCCCGTCCGCCCAAGCGCCCACCCGATCGGGAATTGTCGCCAAGCAAAGAAACCGGGTGGGCGCCTAGGCAATTTCTTTGTTGGCGAGACGATGGTATCACGGGACCGCCGGAACCCCGCCCGGGTATCACCCGTTATCTAGACTGTTAGATTGCTCAATTTAACCTGACTTCCCGTCACTTCCTTAGCCCACTGGACGCAGGGCCGGATCGCCGCCAGCCCCGAGAACCTGCGCCTAGCTGCTGAAATGCCTTGGCCGTCGCTTGCGTGCGGCGGCCACATCTGGTATCATGTGGCATAAGGTTTTCATTTATTCCACAGGAGGCGGGCATGTACATCAGCCACGACGTCGTGGACGGCAACGAGTACGCGACGGTCGTCAGGTCCGTGAGGGACGGCGCAAGGGTCACGAAGGAGGACCGCGTGTACCTGGGCCGGGTCGTGGACAGGGCGCGCGGGGTGTACCGGAGCAAGGCCAGGGGCCTGTTCTCCTACGACCTGGCGACGGGCGAGTTCGGGCCCGCGCCGGAGGGCGTCGAGGGGCCGAGGAGGCGCAACGCCCGCGCCGCTCGCCCGACGCTCGCCGTGTCGTTCGGCGACGCGTTCCTGCTGGACTCGTTCCTGCGCTCGAGCGGGCTGATGGCCTGCGCCGACGCGTGCGGCCACGCCGAGCCCGACACGGTGCGGGCGCTGCTGGCGTTCTACGTGCTCACCGGCCTCGCCAACCGCCACGCCGGGGACTGGTGGGAGCTCACCTACGCGAGGCTCCTCTACCCCAGGGCCAGGATGGCCTCCCAGAGGGCCGGCGAGTGCCTGGCCGACCTCGGCAGCGAGGACGCCAAGCGCCGCTTCGTGGGCGAGTACCTGGCCCTCGTCGGCAGGCGGAGGGAGGCGGCCGCAGGCGGGCGCGCCGACGGCATCCTCATCGACTCCACGGGGCTGCCCAACTCCTGCCGCCTTCCCGTCACGGCCGTCTCCAACCACAACGGCGAGGTCAGCGAGGAGGTCCGCCTCATCTACGTCGCGCAGCGCGACACGGGCATGCCCCTCTTCTTCCGCCACGTCGCCGGCAACGTGATCGACGTCTCCACCGTCACCCGCACCATCGCCGAGCTCAGGGCGATGGGCGTGGACACCAGGTTCGCCGTCCTCGACGCAGGCTACCACGCGAACGCGAGCGCCGACGCGCTGATGGGCGCGAGGGTGCCCATCCTCGCGAGGATGAGGCCCAACCTCAGGGCCTACAGGGAGGTCGTCGCGGGGCACCTCGACGGGCTCGAGGCCAGGGAGAACGCGGTCATGCACAATGGCAGGCTCGCGTGCGTCAAGTGCGTCCCCTGCGCCCTCGGCTCCAGGGGAGACCGCAGGGGCTACGCCTACCTGTGCCTGGACGCCGCCATGCGCCGCGAGCTCGAGCGCGACGCCGCCAGGAGGGCCGCCGAGGGCGGGCTCTCGGGCGCCGAGGCCCACGACTCGATGGCCTCGAGGGGCGTGTTCGTGCTCGCCGGCACCAGGAGGATAGCCAGGGGGAAGCTGCTCCCCCTCTACTACGCCCGCGACCGGATCGAGAAGGTCTTCGAGATCGCCAAGCAGGGCGGCAAGGCCCTGCCCGTCTGCGTGCGGAGCGAGGAGACCTTCAGGGGGCACCTGCTCATGTGCCTCGTGGCCACCGCGGCGATCAAGATGATGTCAGACGTGCTTGCCTCGCGCAAGACCTCGCTCACGGTCGAGTCGATGCTGAGGATCCTGCACGAGCAGCACGCGATAGAGTACGACGGGCGGCTGGTCACCACCGAGCCGGTCAGGAAGATGAACGAGGCGTACAGGGCCTTCGGGATCAGGTGCCCGGACACCATCGGGCTGCCAGTTGTGGGCTAAGGAAGTGTCGGGAACTCAGGTTTAACTTGACAAAACACAGGAGAAGAGTGCGCCCCTCGCCAGGACCAAGCACGTATGGCCGGGGAGGGAGGCGAGCCCCGCGGGGGGCGAGAGAGGAGGCGCGCGCTGTCGAAGGAGCGCCCCGGGACCGCCCGCGCCTGCGCGACGAGGGAGGCGTCGCGGGCGACCTGCGACTGCGGGGCCAGGGACGACGCTGGGTCGGGGCCGAACGCCCTGCGCGGCCGGGTCACGCGCCCGGACGTCCCCCGGACGAGGACGGTCGCCAGGACCATGCGGGAGCGCAGGGCCGAGATCCCGGGCCACTCCGGCCACGGGCCCGCCAACGCCGTCCCCGGGGGAACGAGCTCGGCGGTCCAGTCGGCCAAAAGGCAGGCACGAGGGCTCGGTAACTTGGAGTACCTCGAGACCATCATCTACCCGAGACTAGGAAAGCTACGTTTTCCCAGACGTCCCTCTGTGCTACCCACTAAAAACCGCGAGGAGCCCAATGTTCTTTGTCGAAACTTGCATATATATTAACATGTGGTATTATATATACAAATGGAAAACGCGCACGACATAGCATCCGGTTACACGACCTCGCAGGCGGCGAGGCTCCTAGGCGTAGGCAGGCACGAGGTGGCGAGGCTCGTGCGAAACGGCATCCTCCGCGCCAGGAAAACCGACTCCGGCACCCTCGCGATCGATCCCGGCAGCGTGCACACCCACGAGGCGCTCTCGCAGTTCAAGGGTAGGCCATGGAGCCCGCAGACCGCCTGGGCGGCGCTTCTGGCGATAGGCGGGGACGACGTCTCCTGGCTCGAGTACCACAAGAGGCGGCGCCTGCTCCTGAAGCTCAGGGAGATCGGCGCAGGAGAGCTCATCTGGCTCGCGCGGAACAGGATGGAGGCGAGGAGGTACCTTGTATCGCCGTCGTTCGAAGACGACGTGCGGAAGGCGCTCGTGGCCACGGGGATGGCCTCGGTCCTTGCAAACGACCTCGGACTCGCGTCGACGGCCCCCGTCTTGGATGGGTATGTGGTCGGGATGACTGCGGAGGAGCTAGAGCACGACTTCTTCCTCGTGGAGGACGCGACGGGCTCGTGCACCGCGAGGTTCGCGAGCGACCTGCCCGATTCACTGGCTGATGCCACAGAGATGCCTGCGGCGGTCGTGGCCGCTGACCTGGCGATGTCGGTCGACGCGCGCGAGCGCAGGTGCGGGCTCGACTACCTGGAAGGGCTCCTCGATGGAATGCGCTGAACTGAAGGTATCGAAGCTCATGAAGCCATGGGATGTCGTCATAGAGCTCGGAGACGGCCTACCGGAGGGCTCATGGGCGCTCGTCGGCGGGCTCATGACGCAAGCCCACGCGATGATCGCGGGATGCCAGTCCCGCGCGACCGTGGACGTCGACGTCCTGGTCGACGTGATGGCCTCGACCCCCAACATATCCACCGTGATAAAACAGCTTGAAAGTATGGGGTTCGCCCTCAAAGAGCCCGGTTTGCGCGGCACCGCCTTCCACCGCATGACGCGCGGAGCACTCGTCGCCGACATCTTGGTGGCCGACCACCTGCCTTCGGGCAAGGCCAGGTCCGCCAAGGTCAACGGGTGGCCGATGATGGAGATCGCAGGCGGGGCCCAGGCGATCGAGCGGGGCATGGACCTCGCGCTGATCCACGAGGACGGCTCGACCAGGATACGCATACCCGACCTCCTGGGAGCGCTCGTCCTCAAGAGCGCGGCATACTGCGCGGACAGACGCGACAGGCGCCGCCACCTGGACGACATCGCGCTGCTCGCGAGCCTCGTCACCGACCACAAGGGCTGCATCGAGCGGCTTCACGGATCGGACAAGAGGCGGCTGCGGACGGCCGCGAGAGCGCTTTTCGACCCCAACAGCAGCTCCTGGACGCGCCTGAACCCCGAGAAGCGCAAGGCGGGGCAGTTCACCCTCGCCGTGCTCACCCGATGAAGGGACGGACAAGGGCGCGCGTTCGTCGCCAGGACCACCGATGGGCGCATGCGTGACCGGGTCGCACTTGATTCCGGAAATGCCAGCGAATACGACCTGAAGATCTCCTCGAACAAAGACGGGTTTGCGTCTAGTCATGCAAACGATACCGCCGTGCGCTCGTTGCACCGCTCACCGACACGAACTCAAGCTCCGTTAGCCCGCGTAATAATACGTTAGTCTGAGAGGTCCCCATTTTAATTCCTTGGGCTATTTCTGCAGTTCTTGAAGGCCCGTTGGCTTCCAGATAATTCAGCACCGCCCTCTGCGCGTCCGTCAGCGAATCATCGCCGCGCTTCGACGGTCTTCGACGGTCTTCGACGGTCTTCGACGGCGCTTCGCCGGCCGAATCGGCAGAGACGAGCGGCAGGGTGAGCGTGGTGCGGTCTGGGCCGTAGGCGACCTCGTAGCCCGGCTCGGCGTACCCGGCCCATGCCCAGCCCCCGAAGATCTTGTCCATGCCGCTGCCCGCGCGCTCGCCGATCTCCACCATCGCGAACATCCTCATCATGGTCTCGTTGCGCGGGTCGGTGCTGCCGGGCTTCTTCGCCTCTTCGACGGGCATGCGGAAGTCTCCGGGGTTTGCGATGGTGATGGCCTCGTCGTCCCACACGCACACCACGCCGCGTCGGTCGAACCAGTTGGCGTTGGTGAGCGCGTTGACTATCGCCTCGCGCAGCGCCTCGTGGGCGGGCGTGTCGTCCACGCGGTCGACGCCGTCCAGGCGGAAGGGCACCTTGAGCGCCGCCTTGAGCTTGTTGTACACGCGGAAGTAGAAGTCGTATACGTTGCCCGTCCAGTCGCCCGGCTGGCTGGTGAAGCGGTCCTCCCAGCGCGTGTCGTGGCCCGTCTCCTGTCGATAGTCCAAGAAGAAGTGCGGGAACTCGTAGGTGATCCAGCGGTCCTCGCCGAACATGAGGAGTCCGGCGCGTGTCGGACGTAGCTCGCCGTTCTCGTTCACGCGCAGCGCCCCGATGTCGGTGAGGAAGGTCTCGTCGTCGGCCTTGCCCCACACGTGGCCCTCGTTGCGCTGGTCGAATCGGCGTCGATAGGCCGCGACCGTCTCGCGATTGATGAACTCCACGCGAGCGCTCTCGGCGATGGCTGCGTCCTGGCTCGAGGTGTCGGAGTCGCGCAGCATCGAGAGCACCTCCTCGCGCTTGCACTGGTGGTCGCCCGTATGCGTGCGGCGGAAGGTGCCGCCGAAGATGCTGTTGTCGATGTAGACGGGCCTGGTGCAACGGTCGACCCACGGAACGCGAATGACCACGATGTCCTTGCCTTCCACGGTCTCCACGGTGGCATCTGCGTCCTTCATGAAGCGGGCGGAGAGCTTGTCCTCGGAGAGCGCCGCGTTCCAGAAGTCGTCGAGCACCTTCTCGGCCTTCGGGATGCCATGCACTACGAAGCTGCCATCGTCCCTTGCGCTCGGAGACGCCCAGCACGATGACGCCGCCGGCCGTGTTGGCGAAGGCCGAGACCGTCTCCCACGCGCTGCGCGGAAGCTCGCCCTGCCCGTCACGCCCAAGCGCCTTCTTCGCCTCCAGGCGGTTGCCCTCCCGGTATGTCTTGAGTTCGTTGAGGTCGAACATGTAAGCCTCCGTCCGTCCTATCTCATTCTTGCTCATCATTTGGCTTTTGCGCCGAGAGAAGCCTATCGGTTAAGTGGCCGAATATCGCCCTGTCAATCTTGGTCTTCATGATGCGCATGTTGTCGTACCGTTCGGCATTTGCCTGGAGCCACGCTCCAATATCCGTCGAATCTATGGAAACACTGATTTATTCAAGTCTCGCCGGAGTCGCGCAGCAGCGGGATCCGGGCCCTGGCAGCGGCCTGTGCCTGTGCCTGTGCCTGGGCCGTACGCATGCGGGCCAGGCGCCCGGGCATCTCCCTGTCCTCCGTGCCCAGCGCCACCGCCGTCTTCGACCCCGCCAAGCCGTACCTCCCGTCCTCGCCCCCCGCCGGCGGTAGCATGCCACACCTGCAGTCCAATTACTTCGTGGATATTATACTGGTCGGTTACATCCCGATACACAAGATCGGAGAGGGACGGCCTTGCACAGTGACCAAGGGAATCGTTCTGATGGCAGAAGGTTATGCGAAGTCGGTCTACCGCCTGAGCATTCTCATGCCGGCACAACTTCGCATAACCGACGCCTTCTCATAACGGTGGAAATGAGTGAACACGAGAAAGGAAAGTGGCTGTCAATAGTTATACACTTCTGTTAAACTTCTGCCATGACGCACTTCGACGACATATACGAGATAGCGGCGGACAACTATGGCCTCGTCACCTTCGCCGAGGCGCGGGAGGCGGGCGCCACGGGCGGAGAGCTCGGCCGCTGGGTCGCCCAGGGAAGGCTCGAGCGCAGGGGGCGCGGCACCTATCGCCTCGTGAGGCGCACCCCCACCCCCCTACGACCGCTACGCCGAGGCCGTCGCCCTCGTGGGGCCCGGCTCCGTCGTGTGGGGCGACTCCGTCCTCGCGATGCTGGACCTCGCCTACGAGAACCCGCCCGTCGTCTACGTCGCGTTCGCGAGGCGCGTGCGAAGGGCGCTCCCCGCATGGGTGAGGCTCGTGGGCGAGCACGTGGACGAGCGCACCGTCTACGAGGGCGTGCCCTGCCAGGCGCTCCCCGAGGCGATCCGCGCGTGCAGGGGGCACGTCCTTCCCGAGCGGCTCGCAGACGCCGCGCGGGATGCCCGTGCGCGCGGGCTCATCACCAGGGCGGAGGCGGCAGAGCTCGAGGAGGACATGGCATGAGCGGGCGCAAGAGGCCCAACAGCAGGCGAAACCTGGACATAGCGAGAGCATTTCACGGGCATGATTACCGCGCGTCACGCGACATCCGAGAAGCCAGCATGCCGCCCATGCGAAGCCACCGCAGACCCGCGCACACCACACCACCAACGCAAGCGCCTCTGTACGCGGCACGCAGGCCCCGCAGTAACCACGCCGAAGTATTCCCACGCGCTGCCACCACGCAAGACCCCACCCCATCTCGCCTTGTCCACGAAGACTCGCCCACAGCCCGGTCGGCGCGAGGGCCGCGAAAACGTACCCTAAGGCCGTCCCGTCACTCGTCTTCGGCCTTGATCGACTCTGCATCGACGTACTCGAACGTTACGTAGTCGCCCAGATCGAGGAAGCGAACTCTTTCAGCTCTGCCAGCGCCTGCTCCAGGGTAACTCCTTCGATAAGGATGTCTATGTCGCGCGTCGCCCGTGCGCCTATGGTGCGAGCAAGCATGCTCTGCCCCCTTTGGGGGGAGGAGAGCTTGGGCTGCTGAACACCCGACACAGCAGGCGATGGAGGTAGAAGCCGCAGCGGCGCGTCCCGTATCCATGCTCGAGGCTCTAAACGTGGCGGTAACCGCCATCTCGTGGGCCTCGGGGGTCTTGTACCCCATGTCAGGATCCCCCTCGTCCAAACAGGGTCATGCGGACCCGCCCTGCCGCCCTGGCGCTGCCACAGGCGTCTATAGGGTAGCGGAGCCTACCCTCGTCAAGTCCCGCCTTCCTCGCATCGGCGAGCGCATCGCGCACAAGCGAGGGATCCTCGCCGAGAAGTACGAGGTCGAGGATCGTCCGCTTGATCCTCGTGACGGGCAGGCCGTTCTTGAAGATGACGTCGTCGCGGAGGAGCTCGCGGGCGGCGAAGGTTACGCCTGGGAAGCGGGAGTGCACTCGCTTGGGGCGATCAGAACATAGGGGCTCAGGTAGAAGTCCCCGATGCCATGGATGCTCGCGGCGGTGGTGCCCCCTGCCACGATGCCGTCCCAGGCGCTTGGCTGGACCCTCTCGTGCGTGAAAAGCGAAGGGGCGGTCAGCTTCCAGATGGCCTCGAGCTCGTCGGTCTCGACCGAGGGGACGCCCGCCATGCGGTAGGCGTCGTGCATCACGCGCAGGAGCCTGCCTGCGACGCAGGCCTTCGCGAGGGCGTTTCTCGGCACCCCGAGGCGCTTTACCTGCGCGGTCATGAAAATCCTCTCGGAGGCCGAGAGCTCGCTGGTGGTCTGCATGTGGTCGCTTCCATCTATGGTACGGTTGTATCGTATTTCGATACTTTTGTGGCTCATGTTTACCTGACAAGCTTCCTGACGTCTGAGCGTTACTGTTTATATCACCTGACTTTGGTATTTGGCTCCCATTTATGGTGCTATGAGGCCCCCTTGCAACGCCTCCCGTTGGGCGGGGAGACCTTACCCTCGCCCCGGAGCATCCCGAGCGTGCAGGACGAGATCGCCTTGACGTCGCCCTTGCTGAGGTTGAAGTGCAGCAGGGGCAGGCCGGTCCTGGCGGCCAGCTCCTCGATGATCGGGGTGCGCCTGGACACGTTGACGTACCTCCTGTCGGAGGCCTGGCACACGTCGAGCCCGCGGCAGAGGCCCATCACGTCCTCTGAGGAGTACCGGCCCCCGAGCACCTTGACCTGCAGGAGCCTCACGAGCAGCACCGCTAGGTAGCAGACGAGGAAGTGGCCGGTGATCGTGCTCTGCCTCTGCAGGTAGACGGGCCTGGCGTCGAGCTCGGACTTCATGACCCTGAAGCTCTCCTCGATCCTCCAGAGCCGGTGGTAGGTGCCGTACACCTCGCGGGGCGGCATCGAGGTCTCGGAGGTCACGAGCATGTTGTACCCGGCGACCGACCTCGCCTTCCGGATCGCGTCGTGGTTGAGGGTCGCGACGACCCTGGTGTCCTCCCTGACCTCGCCCTCGCCGTCCACGGGCTCGAAGGTGACGTACCTGGCGCTGTCGCCGTACTCGGACCTCCTCGCCGCCGCGAGCCTGAGGGCCCTGGCCTTCTCCACCTGCCTGTCGATCTCGCGGGTCTGCTTCCTCGCGAGGGCGGGGCTGTAGGTGACCACGCGCCTCTCGGGCAGCGCCACCACCCTCCTCCTCCCGCCGGCGTCCGTGACCCCGTACTCGAAGTCGCCGGTCGACGCCTTGTGGCTGAAGGCGACGCCGCCCCGCCCGTCGGGCACGTCCTGCCAGCCCTCGTCCGAGAGCGCCCAGGCGCGCTCCCTCGCCGGGAGGGCCTTGACCGACTTCGAGAAGATGTAGCCGTCGCCTGACAGCACGGCGTCGACGACGTTGTCCGCGCAGTCGGGGCCATTGTCGGCGACGCGCACGGTCCGCCCCGATATCGCGTTTCTCTCCTTCAGCTGGCTGATGCACCTCTTGAGCTGGGGCCTCTCGCTCTCGTTGCCGGGGAACACGCTCATCGCGATGGGGACGCAGTCGGCGTCGAGGAGGAGCCCCATCCCCACGATGGGCTCGGGCCTGTGCTCCTTGGAGGGGCCCTTCCTCCCGGGCTGGTCCTCGCGGCCGATCTCGAAGCAGAAGTTGGCGCGGTCGAAGTAGGAGGTCGTGGTGTCCCGACCGAAGAGGCCGCCCACGCGGGCGTTGTAGATCTCGACCACCTTCTCGTACTCCTCACCCAGGTAGGCGAGGCCGTCGTAGAGCTGGTCGAGCGTGAATCCCGCCTCGACGCCCTCCATCTGCGGCAGCACGTCGTGGAAGGTCCTCGACTTCGAGCAGGGCGCCACCGCCCGGGCGAGGACCAGGCAGGAGAGCAGGTCCGCGAGCGAGAAGCGGAAGCCGCTCGGGACCTGCAGGAAGGCGAGGTCGCCCCTGACGCCGAGCGAGTCGTCTATGGCCTTGAGGGCGAAGTGGCCGAGGTGCCTCTCGGAGGGGGCGTCCGATATCTCGCGGACCCTCCCCCTCTCCCTCTCGGCCCTGCGCTCGGCGTTCATCGAGTCGACCTCGGACCTGAGGTGCGCGATCGGGTCGGCGATCCCCGACTCCCTGAGCTCGTGCTCGTAGCCCACCGCCCTCACGGACCTGTTGACGGTGTGGCCCCGCCCGGGGTCCCAGTGGCTCTCGTAGATCTGGAGATAGAGCCCCTTCTTGTTCCTCGTCCTCTTTAGGAAGTAGGCCATCGTCGCCTCCTGTCGGGTGAAAGCGCTATAACACCATAGCACCATATATATATCCTACCAGAGACGCCCTTGTCAAGTCAAGTCCCTGCGCATGAAAATACCAGCTCAAGGCTGGTTTTTACGGAAGCGGGCCGCGTTCGTGACCCTAAGGTGGCTAGTAGCCCGTTTTGGTACTAGCAATCAGCAAAACCTGGTACCGTCAGTCAGCAAGCCTGGTACTGCAGGTAAGGTCGTTTGGTACCGCCGGCATCGAACCTAGAGTTCCATGATGCACGCCTGATCCGGGGCGCGCTTCCATGGAAAGGGGCTTGATGCCCATGTCTAGGAACAAGAGGATCCTCATGTTGCTCGCGAAGGGAGGGGTCAGCCAGTCCGGCATCGCCGCCGCATTGCACGTCAGCAAGCGAGACGTGTCGGCCGGCGCGAGGGCGCTGCGCGAGCACGGCCTGACGTTCGGCGCCGTCAGCTCCATGGACGCCGACGTCGTCGATGACCTGTTCTTCCCGAGGGAGAGGCGCGGGCCGAACGGCGCCTGCCTGCAACCGGACATGGAGTCGCTGGTCGAGCGCAAGAAGAGGAACCGCAAGCTCCCGGTCAGGCTTTTCTGGATCGAGCGCTGCGAGCAGGCTGCGGCTGAGGGGAGGCTGGCGTACGCCTACCAGACGTTTTGCGAGATGTTCGCCGGCGTCGCCGAGAGGATGGGCGCCACCAGGCACTTTATCCACGAGGCCGGAGCCAAGTGCTACATAGATTGGGCTGGCGACACCGCCCATCTCACCGACAAGCTGCTGGGAACCAAGACGAAGGTCCACGTGCTCGTCGTCGTCCTCCCGTTCTCCGGCAGGTTCTGGGCGGAGGGCTTCTGTGACATGAAGCAGAGGTCATGGCAGGAAGGCCAGATGCACGCGTTCGAGGAGTTCGGCGGCGTGCCGCGCATGTGGGTGCCCGACAACGCCGCCACGGCGACCAACCGCGCCGCCCCGCAGGTCACTCTCGTCAACGAGGAGTACGGGCGCCTCGCCGATCACTACGGCGCGGCGATCGTCCCCGCCCGGGTCCGCAAGCCCCGTGACAAGAGCGTTGCCGAATCGGTTGTTGGCCTGGTGGAACGCTGGATAGTCAGTCCTTCCAACGAGATGGCATTCTACACCATCGACGAGCTCGGCGAATTCTGCGCCGATAGGGTGGCATGGCTGAACTCCCGCCCGTTCTCGGCCAAGGACGGCTCGCGCGACTCGGTCTTCGAGGAGGAGGAGCGCCCGCACCTGATGCCGCTTCCCGCCGAGCGCTACGAGATGTGCGAGTGGCGAAGTCCCAAGGTCGCACCGGATTACCACGTCGTGGTTGACTACATGAGGTATTCCGTGCCGTGCCGCCTGGTCGGGGAGCAGACCGACGTCAAGATGACGTCGTCGACGGTCACGGTGCTGCACGGCGGGGAGGTCGTCGCGGTCCATCCGCGCCTGCGCGGGCGCAAGGGCCAGTACTCCACGATCGACGATCACATGCCTGAGAACCATGCGGCGCTCGATAACCCCTGGTCTCCGGAGAGATTCACGTCTTGGGCGAAGCGCATCGGGCCCGAGACCGGCATCGCGATCGGGCGCGTGATGGAGAGCCGCGTGATCGTCGAGCAGTCGTTCGTCTCCTGCCGCAACATACTGGGCTTGTCGAAAACCTACACGCCGGCATTGCTCGAGCGCGCGTGCGCCAGGATGAACGCGGCGTCCGCGCTTCCCAGCTACACGGGAGTGAAGAACACGATTCTCGCCATCAGGGCCGCCGATGTGGAGCTTGGCGCTGCCGGCAGGCGCACGCAGCCGGCCGAACCCGGCGAATTGGTCGATCGCGCCAGGTCGGCGGGGCGCCTACGCGGCGCCGACGCCTACAAGAGGGGCGGTGATCGGCGATGCTGACGGAAGAGCACTTCGAGTTGTTCAAGGAGTTCCGGGTAAAGGCCATGGGAGACAAGCTTCGCGAGATGGTCGAGGACGATTCCTACGACGCCTATACGTTCGAGGAGCGAATGGAGATGCTGATAGACGCGGAGGCATCCGCCAGGCGCGAGCGCAAGGTGGCCAAGCTCGTGAAGCAGGCGCGGTTCAAGACGCCCTCGGCATGCGTCGAGGATATCGTCTACCTGCCGGACCGCAAGCTGTCGAGGGATCGAATCGCGCGCTACGCCGAGTGCGACTGGGTCGAGAAATGCGAGGTCATGGTGATAATATCAAAAACAGGTGGGGGCAAGTCGTATCTATGCCAGGCGCTCGGCAACGCCGCATGCCGCAAGCTGATAGAGGTCCGCTACACTCGGCTTGCCGGCATATGCGAGGAACTGAACCGGGCGCGTGCAGCGGCGGACGGGAGCTACTACGAGCTCATGGACGGTTTGAAGACGATTCCGCTGCTCCTGGTAGATGACTTCATGACCACGCCGATAACCACGCAAAACGCCGTCGACCTATTCGAGATAATGGAAGCGAGGGAGAGCTTGGCCGCAACCCTGATCGCCTCTCAGCTGGAGCCCAACGAGTGGTACCTGCGAATCGAGGGAGAGCTCATGGCCGATTCTATCCTAAACCGCATCGCCACCGGCGCTCGCTACATCGACCTGGAAGGTCCCAACATGCGCGAGTATTTCGCAAAGAAGAAGGTTGGGTAGCGGTACCAGATTCAGCTTACTCTCGGTACCGCTCTTTGCTGATCGGCGGTACCAAGCTAGGTGATTGGTGGTACCGAGAGAGCTTACTACTCAGGCAGATGGGGGACCGTCCTCGGCGACGACCAGATGGCTGCGGCAGCCGTCGACCGCGTCTGCCACCACGGGGGGCTGCCCCGGTCCGGGGGCGAGTCGCGCCGCGCCGGGCACGCGCCCGTGTCGGGGAAGGGGGCGGCGCGACGGCGGCGGGAGACGGCCCGGGGGATGGCGTCGTGCTCCGGGGCACCCGTGGCGACATCGTTACCCTCGGTGACCCCGGACGCGCGTTGCGTCACGTGTCCGACGACGCCATGCCCTCGGCAAGGTGCGACGGACTCCCCCGTGACGGGACAGTCGACCTGTGGATGGGGGAGGTGCGCTGTGACGGCCCCGATGCGCTGGGGTTCGTCTGGTGCGAGGCCGTCCTCCGACCGGATGGCGAGCCCCCGGGGCCATCGGACTGGCGACCCTCCCGTCTCGGTCGGGCGACCAGGACGGGAGGCACCGGATTTGGGCGACAGACGCCCAAATCCGGTGCGAACCCTGCCCGAATCCTGGTGCGATTTTTGCTCAATTTAACTTGACAAAACACATCCTCGCGGCAGCGGAGCTCGTGCCGGCGCCCCTGAGGGCGAGGTCGGAGCCCAGGCTCGGGGCGCCCATGCCCGACCTGTCGCGGGCGGGCCCGCCCGTCATCGGCGAGACGGGCCACGTCCCTCCCGACGCTGACGGCCCGAGGCCGCTGTCCCAGGTGATGAGTGGTCGCCACGAGAGGCGCAGCACGGTCATCGCGACCAACGTCGGGTCTAGCGGGTGGGGTGCCGTGTCCGGCGACGACAGGCTCGCGGCTGCGGCGATCGACAGGATCGCCCACCACGGTAGGCTCGTGGAGTTCAACGGAGGGAGCAGGCGCATGGACGAGGCGCTGATGCTCGGAGAGTCGGAGGGATGGGAACGCGGGAGGGCCGGTGCTGAAATCAGAAAAAGCTACTTGACGAAACACGTCCACCTGGGCGGCGAGCACGGGGGCCGACACGCTCCTCCTCGACCTCGCCAGCAGCCACATGGCGTGGAACCAGCGGCGCGGGCGCGCCTCGGGGTGCCGCGTGGCCGTCCCGACCGCCGCCGAGAGGTGGTGGGAGCACCTCGCGCGCCGCCGGATGCGGTTGCGGCTCGCGACGGGCGAGCACGTCACGCACCCTCACCTCGGGCACACCCAGCCGTCCGGCCACCTGACCCCCGTCAGGCGCCTCTCGCAGCTCCATCGCCCGGGTACCTGGCCGGCAGGGCGTGGAGGCTGCCCATCCTGCCCATCTCCCCCTGACCTGCCTGCGCCTCGCGTTGCCCATCGTGCACCCCCGTCTCGGCCTCCGTCCCTCGGTACCGTGATACGACAAGGTGGGAACACATGCCACCTGCGACTATGAATCACATTGGGGAGCATTTAACTGAAACGATACTTACTACGAATGTGAATCATTGCTTGCATAGTGTTCGCTTACCCGCCATCTAGATACATTCATAAACGTTGAATCCTCAAATTGATCGAGCACCTCATCAGGCAGCTTAAGTCTTTTCATAATGATTACGTAGGCAATTAATATTTGAGCATCGTGATGATCGACCATTTGCTCATACTCGCTGTTGTTCTCCAAAGCGTGTGCGCTCGCATTCCTGAGTTTATTCTGCTCTTTTCGAAAACGCTTCCAATCTGGCACGATCCCCCTCCCCCATCTGTCGCTCTCTTCGTAAGCGTGGTCAAGCAGCATGGAATAGGAAGGCTGTCTTAGTAAGCCCAGCAGCCCCCGCGCCCTATCCCGGATAGATTCATCCGCCACCCTCAGCATGGGGGTAATCAGGCATTCCAAATCCTTCTTATCGAAACACTCATCACACCCTGAACGAGCCAACGACTCGAACATCGAACTTGCTGCAAAAAACTTTAGATCAACAGGAATTTTCCAAGATCCCAAAAGAGATACGAGCATCTTACTCGATTGGGACTCATCGCCTTTCATCTCCATCCATCGGGTAACCACATCAAAAAGAATAGATTTAATGAGCTGAAATGGTACGGGAACACATTGATAATTTCTTATCGTGTTTCTGGTGAGAAACGAACCTCTGTGCACTTCAACAGGGCTACCATTGTCTTTGAACTTAACTCTAACCTGACGTATGGAGGTATACGCGCCAAAACAAAAGGATAAGAATGATTGGAATTTCCACAGCTCACATGACCAAAAATCATCGAGAGAAACCCCGTTCTTATAATCGACGTGAACTGTCGCGTAGGTCGAATACCTGAACCCCTCATGATCACTTTTTATCTTCCCGATACCAGAGTGAATTGTCATAGCACATCTATCGGATCGGTATACGTCGATGACTTCATTTTGTCTCCCACCCTCTATCACAAGGTTATCCTCTCGGATTTCCGGGCTAGAATGAAGGCCCAGCCATTTACGGAGACCCTCAATCTCGAAGTCAGCGGTACTTATGGGAATGCTGGGATCAAATTCATCGTGAGATGACAGCACCGTACTCGCTTCAAGGCTTTCACGGGTGTGTCCGGGAAACGAAAGCCCTACTCTGTTCGAGATGGCGTCGATAAGCAAAAGGTAAATTCCATCCTGGGTAATCCCAAAGAGATATTCATACCGGTCAGACTCCATCCCGATTTCACAATGCCCCGTCTCTGCCAATTTGCGGGTCAGGCTGAGGTCCCCAGAAGGGATCTCGAGATGAACCCCTTTATCCTCAGAAAACTGGCAGAATCCTTCAGCATTATATTTCTTCGCCTTCAAGTCATCCCAGCTACGGTTCCACAGAGCCGTTTTCCAGACCTTATCTTCCATCCTTACCTCAATCTTTGCGTAGCAGTATGACAAAGCAGTATGACAACTATGGCCTGGTACCGGTTCCTCCTATGTGTTTTGGTTTTCCAGAGATGGTATAGAATTTTATGGTAGTGTGCCTCCTCGACACAACCTCATTCCAAGTATCTGCGTGATCTGTTACCCGGTCCATCATGGATCCGTTGTACACATCCCCCTTTCGTCAGCTCACCTCCCATGCAAGGATCTGAGAATCAATACTGTTATTATCAGTTCTGATGCGAAAACTCTGTGTTGGTACCAAAAAGGGCTCAGTCCCTGAGCAATATCTTTCCCAGGGCCGTCGCAATGGCATGGACGTCCCCTTCCCCATTGTGCTTCCCCAGCGAGATGCGGACTGTTTCTTTTGCCTCAGCCTCAGGTAGGCCGATGGCTTTGAGAACATGGGAGACCCTCGTGTTGGCACCATCGCAGGCCGAGCCTGTCGAGACCGCGATCTTCATGAGATCAAGCCTGTGCAGAAGCATCTCGCCGCTGGCACCGGCAAAGGACAGGCTCATGAGCCCGGGCAATTGGTTCTCCCCGTTACGTCGATACGGCACTCCCAGGGCAGCGAGGTCATCGAGCAAGAGGCGCTCGAGCCGCCCCAGGCGAACGGCGTTAGCTTCGATGGCGTCACAGTTCTCCTTAAGTGCCACGGCCATCGCAACGATGGAGGCTACGTTCTCGGTACCAGCGCGACGTCCCATTTCCTGGGCACCGCCGTTAGCATAGGGGGCAAGGGGCGTCCCGTCCTTGATGTAGAGAAACCCTATCCCCTTCGGTCCGTTGAACTTGTGCGCAGAGGCAGAGAGCATATCGACCCCCATGGCCTTCACGTCTATCTCTACATGCCCCACAGCCTGAACTGCGTCCGTGTGGAAGATCGCCCCCTTCGAGTGGGCGATGTCACAGAGCTCGCCTATCGGCTGAATCGTTCCAATCTCGTTGTTGGCGTACATGCAGGACACGAGAGAGCCATCACCCAATGACATTTCGCGCAAGGCATCAAGAGCAATAACTCCTGTTCTGGACACTGGCAATACTGCAACCCTATGGCCAATGGCGCTCATGGCCTTGCAGCTGTCTAAAACTGCATGATGCTCGATTTCTGAGGTCACGATTTCTCTCATCATATCGTCACGAAGTGCAAAGCCCTTAATTGCCCAGTTATCGCTCTCTGTTCCGCCAGAGGTAAAGACAATCTCCCCCGGGTCAGCGTTGATGCAAGATGCAATGGACTCACGCGCCTCACGCAATGCCCGTTTCACAGGGCGAGAGAAAGCATAGGGCTGAGAGGGGTTGCCGTACTCGTCCACAAGGAATGACGTCATGCTTGCATACGCCACGACACTCAGTTGCGTAGTCGCGGCGTTATCGGCGTAGATGTATGAGTTCTTGGACACGCTGCTCATTGGAACAGTGCACATCCCTCATCCTTAAACTCCTCGATCTTGTCAAGAAGATCATCGACGCTGCAGTCAAGATAGGCTGCAAGGCAATCGAGGCACAGGACGTCATCGTCGCCCTCCCCAAGCAGTTTCTTCGAAATGCCCACCTCGTCCTTCGTGAGCGACTCCTTATAACATGACTTACAGGCTACGTTTTTCATAGTAACTACTGTCGGCTTTCAGGTCTGGGATGTCCTTGCCCCGATACTCGACGTCCATCAGACCAAGTTGCATTCTAATTGTTGCGCGCATCTTGCTTGCACGGCGCAGGCAATACCGACTAAAGTCACGAGGGCTGATGTCCTCAGGCCGCTTGACGTTGGGAAACAGAAGTTTGAGGTATGCGGTTGTGATTCGCTTGATCGCTTCCGTATCGCGGGTATCAGCTGCGTCAGGCACCAGAACGAGCTTGTCCACGATGGCCCGATATGATGCATCGCTTCTAAGCTCATGGAGAATGGAGCAAAAATACTCAGAGTTAAGCGCCCAACCCGATATTTTGAGATCATCGTTCATACGCGGTATATCCCAGCCTTTGATGAAGCCATGGAATCGCTCGATCAGAGCTGACTCGTGAAACACGCTCGGTAATTCCTGGAACATATCCGTCGTACCGTCTTGGTCCATCACCCCTTTTGAGATGTTACCGCAGAGGATCATTCCAGCAGATGCGGTACCCTCATAGCTCCCGACCGTAAACACGCCAGACTCAAGATATCCCTTCAGTGCAGCCCTCATCTCATCGACGTCCGTAAAGGATATCGTCTGAACCTCATCAAGGGTGATGAAATCGTGACCAGCGACAAGACCTTCCGTATGTCGAGAGATGTCATAAAACATCTTGGCCCTGCTCATCACTCCGCCAGACGAAAGCCAACCGTAACGGCTAACCCTGCCAAACAGGTATGATTTGCCCGTGCCCTTTGGCGCCAATTCGATCAGGTTCAACCGCTTCTCACAAAACGGAAGAAGCCTGGTCAGCATGGTAAGCTTTTCTTCCTCGCTCCTATAGCCACGTGGGTTGTAGTCGATTGCGCCCAAAAGCACGTCAATCCACTCGTCAGTGGTGAATTGATTCCTCACGCCCTTGTAGAAGTCAAGATTAATGCTATACGGTCTGAAGTTCTTGAAACTGACCAGACGGATCTTTCCGGGCTGCCTTGGAGTCATCTCGTCATCAGGCGGACGGTAGCCAAGCTCAAGCATACCCCACACCTCACGACCACTCACAAGATCGTCCTTCGCTTGCTCCCAAACAAAATCCTCTATGATTGTCTCTTTCGCAGTAAGACCAAAGTCTGGGAGTGAGAAGGATACTTCTCCACTTCTGACGTCCACCTCGATGGATATCTTAGCGAGTATTTTGACACGCTCGTTGTCCTTCACGATACGGCTTTTTATGGCAATCCAATCACTTTTTCGTGGAATGGACCGCCTGACGAACTCGGTAAGCTCATCGTTGTCAAAATGACCGCTCTCATCTTCGAACCGCCTCAGCAGCCAGTCCCTCATGAAGGAAGGTAAGCTAAGGGCAGAGAAGAAATTGCTAGTACGAAGATCCTTGTAGACGACCATGTCGTCGAAGTATGTTTTGAGCTTATCAGTCATCATACCGCCTTACATAAACCAATCATCATCATTAGTGGTCGCGGAGCGCTTCTGAACCTCAAATTCGGCGACGCCGATACGGTCGTCTTTCTCGTAGACCTCGCACGTATAGGTACCGGCCTTCGTCACGCCATCGAAGCGCACGATATGACGGTTCTCATCGACCTTTCGCGCCTCGTAGACCCTGCCGTTGAGCCGCACAGTGACATTAGCCAAGTGCGAGGTGCTGAAGAGCTCTATTTCAGGCGTTTCCTCGTAACTTGCGTAAGCAACTTTGGTCAAGCAGGTTATCTCGACGCTAGCGTCACGCAACGACAGCTCTATAACAGGAACGAGGACCTCTTCCAAGCTCGCGCCCCCATGTACCTCCACACTTGCCTTGCGACCGCCCTTGAACCGATCGTAATTTGCAAGCACCCAGTAACCGTTCTCTGCTGTAGCGCAGTCTGGCTTCTCATCGATTTCGCTTTCCGGGCAGCATCTGCCGGAATGCTCGCCCTTGGTCGTCATCTCCCATTTCGCCTCGCTATTTGCGATCACTGCGAGCCGACTGGCACCATGGTCCGATGCGATAACGATCTTTCGGTACTTGCGAGCGCTAAGTTGTGTTTGAGCGAATTCAAGCACCTCGTCAAGGATGCTGAGCTCGCGTACGAGATGTATGGGAAGCTTCTCAGATTCGTAGTTGAAGCGGTCCTCGCCGTTATGCTTGAGCTTGTCGAAGTCTTTCCTGGAGGTCTTGTCGCCTTTCCATTCCTCATAAAAGCTCTTATTCATACAGGTCAGCGTTGGGAGCGAGGCCCTGGCCACATGCGTGCGCATGCTGAGGCCAAGATCATGCGAGCGTTGTTGGATGTAGCCGAGATACTCAACCCCGAGGGCGTCAACCCAATACAATTGAGCGCCTTCACCCTCAGTCTGCTCAACGATGGCGTTCCTCGTGTCAAGAGCGTTGTATGCGCGATTTCCATCCTTAGCAAGCATCACCACCTCGTCGAGAAAGGACGACTCGATGGTATTCATGAGCTTCTGTCGCTTGTAGCGCGAGAAGTAGCGGTTGAATAGATCGTTATTCCTGCAGGCGAAGGCGTAGTCGCAGAGGTACTTTCCCAGCGCCGGATATATTGTCTTCAAGTCTGGTGGAATCGCTTGGCTCTCACAGATACTCTCAATGATCGCATCTCTCTCGATGACGGTGTTGTCCGTCAGGTAGTGGATCCTCTGCTTGCCCTTCTGCTTCGTCTCGGCAACGTATAGAGCCATGTAGGACTCACTGGCATCGTGCAGAAGTTGCTTTCTCTCTGAGTAGAGCTCGGGGAACTGCGGAGATTCACAGGGAACGTGTAGTATTGCCCTGGCTATCATTTTCTGGTAGGTCTCGTAGTCAGGTGACTTTTCGATCACGAGCTGAAGGTAGGGATTCTTTGTCCCATTGATGAGGACGTTCAGATAGAAACGCCATTCCCGGTATCCAGACTCCTCAAGGCTATCGTCCTCCAGAAATTCTCGCCAGCATTCTTCGGGGAGAACAGACTCATCAACCCCCGTTATTCTGCCATCCTTCTCGAGGAGCGTGTGGCAAGAACAAATTTTTTGGACGTTCTTTAGCGACAGTGCCGTCTTTACCCTGACTTCGCCATGCAGACCCTTCTCGAGGTGTGACAGAAATCGCTTGAACCCCTTGTCAGCGTCACAGGGAATGCTCTCGTCTATGCTCACCACAGAGTAGTCGAGGATCGATTGGACGCTTGTGTAACGCCGCTCGTTGAACTTCCTGTCCGCCTCATTGATACGCCTGATGTCTTCCCTGATACCACGACACACAACGATAAGCTTATGTGGTAGCAGCAGGTCTCTGAGCTTGCCGAGGAGGGTACTGCTGCCTCCGAGGGCTATGCTCTCACCGACACCGAGCAATATGGTGCTGCTCTCGATTTTCTTAATATCCGTGATGAGTCGGTCCACATCGGGAAAGGAGTCGGTCCTGCAGTAGTCGCTCACGCGAACGATAGAGAGGCCATTCAATGCCTTGACAACGGATGAGTATTCCGTGTTTCCGTCCGCTAGCACAAAGAATGGATAAGGCATATCGCTCTTGCGATATGCAGCTATCCTTTTGAGCGCATCAGACAACGAGGAGGGCTTCATTGCCGAGCCTCTTTCTTTGCGATGATCTCAATACCCACCTCGACGTTTTCCCTAACGAGTCTCTTGAGATACGTCTTGGCATGAGTCGTGTCCATACCGTCGATGAGGTCGATGGCGGCTTGGTTGGCACCGAGCCGATATTTCGACTCCGCCAACGAGCGTACAGCGTCACTGACCTGCTTACTGTCGCACCATTGGTAGACGTTCTCAAAGGCATTGCTTTCGAGGTATCTTCTGACCTCCTCGTTGTCCGTGAGGATCGATCGGTATTTTCCTATCACCTCATGGGAGAAGGCAATCTCCACCCGCTCGTCAGATGACATGAGGCTCAGGAAAACTGGCTTGTTCTCGAGGTATTTTAGTGCCCCATCGACCTGCTTAATGATGGGATTCTCCTTGTGAAGGATTGCAAAGAACGTACGTGCTGCCTCCCGCTCCTCAACGGGGACAAGGGCAAGCAGAGGCGTCTTGTGCTGCTTGGACCAATCGTGGGCATCCTTTGAGTGCGTGCTTTCCTTCCATAGCTTGTGCAGCTGAAATTTTTTCTGATTCGTCCTGATCTCTTCAGCGTGTTCCTGCACGCTCTTTTCAAATGCGGACTTGTCACCCATGAATGAGGACTTAGGTAGCTTGGCATAGAGCTTATTGATATCCGCCGCCCCAAATCCATCTGTATACGTAGAATAGATCTCAGCAAAGATATCTTTCTGTCTGTCCAACACATCCTTCAGGGCACCTGCCTTGGTGACAAGCTGTTCGAGGAAGGCCTCCCTCTTGTCGTGAGAGATCTCGCCATTCTTTGCTATTTCGTAGATACTGGATATCAGCTGCTTGAGATCCGGACACTTCTCTATCAGAACCAAATACGGTATCTTTATATATTTTGTGGTCTCGTTCCATTCCCTCATACAGCTTGAGAAGCTGTTCCTCTTCGTGATGAGCTGATTGCTGCGTTCAACTATGCAGTAGTCAACGAGCAGCTTACGAAGCTCGTTCTCACCGTCCTCCTGATCCCACAGCCAGAGGGCATCACCAGACCCGATTTGCCTCTTGACATCAGCAAGGACGTCCTCGACACCTATTGCTTCTGCGACCTTGAGAATCTGCCCGCCTTCAAACGAATGCAGAAACTCTCGCATCGCCAACGCGCCATTTTCTCTGGTAAAGAGCTTTGTCAGATTGGAAGCTGCGGTCGGAACCTCTTCGAGCATTCTGCCAAAGTCGTTGGTCAGCGCAGGGACGTTCCCGCTCGCGTTCTTGCTCACAATTTCAGACAGTTTTTCAATGAAGGGATCGAGCGCATTCGTGTCGATGCTCCTAAGGCACCAAATCGGGTAACCAAAGTTTGTGAGCTCATTGCGAACGCGGGCGGCAGTCGGCTCAACAGATAGGCTATCCGATACCCCGAAGGCCTCATGAGCGAAGTCTACAAAGCGCTTCTGCTCTTGCGTCATCACCTCGATGTACTCGTCACGATAGTTCCTTACTGGCTTTACCTTATGCTTCATATAGGCGCCAATGAGTTCCGCAAGCCTTTCAACGGTCATTCTGCCACCGGCATCTCCTGAAGCGCCACTGCCATACATGAAGGTACCGCTTGCATACTCTTTGAGCAGAAATCCAGTCAGGTACGCGTAGAGGTTACAGGGCATGAAGCCACGCTCTTCCAGGAAATCATAAATCTCACTTATAGAGATACGCGCGTCCCTGTCGAGACGCTCCTTGATGAGTGCATCAATCTGTACCTTCAATTTACTGATGGGAAGACTCTTCAGTTGAGGGTCGTTCCAGTATTCAGGTGTATTTTGCACGCCCAACAAAAGGCGTGAGATGGCGTCTTGCTGATAGATGCCGCCATACGCCTGCTGTATGCCGACCTTTGCGCCAAACGACAGATTTCTGGATGAAAAAAAGGCTTCTGAGACCTCAATACGATCAAAGGAGAGGGGGTACCTCTTGATCACCAGGTCCTCAAGAACGCCACTCACCCTCATCGTAGATGCACAGTGCTCCTTGAGCTGCCCGACGTATACATCAAACGCTCCGTTAGAGACGTCATTCCTCCAATCGGCAAGAACGTCCTCAGCGCTCTTCTTGTGGTTGTCAGCAAGCTTGCCATCTTTGCTCCGCCAGTATTCTTCATTGGCCGCAAACGAGGCCCAACGGCCAAAGCGATCCGCGCCGAGCACACTCTCCGACGCGTCTATGAATACAATGTCTTTAGAGTTGGGGTCTGCTGTCGCCTCTTTTATCTTCTCGCGAATACGTACCTGTTCGTTTTCGTTTCGCGCAAAGCACATGACTGCTCTAGACCTATACGTTTGTCTCTCATTGATGATCTTGTTGACGGTCGGCCTAAAGTCATCGACGCACGCCAACTTTACCTCGTAGCGTGCCCGTATGGACGGTTTGTACGTGATAGCGGATTCTAGCTGCGCATCGCTAATCAGACGCGCTGTCCTCGTTTCAGCGAGTCGCTTCCTCCTGATAGCGTCGATTTGGACCTGATCACCCGAGACGGCAGCCGCTGCGTACTCATCACCTTCTTCGGTTGGCTTAATATACAGGATCCCCATCTTGACAAGCCGGTTATTGGCAACGCTTACTGCGCGGTTGTTCTCCAGGCTATCGTCACCCTCAAAGGCGAGGTTGAGATTCTTGTCATTGGGTCGAAGAATGCTGACGCTATTGTTGAGTTTCTGACTGATGGCCTGCATCATCAAGATAACCTTAAGAACACGTTTCTGCTCACCATTCAGCTTGTGCTCGTTGTTCGGATATGTATCAAGAATTGTGGCAACGATAAAGTCGAGATTACTCCTACCGCTCATGAAGGTGTTCTCGTCAGTGCCCTTCTCGTAGAAGAAGTTCCACAGGAAGTCGATAGTGAGAACATCGCCATTGTCTGGTCCATGCGTGTTAATGAACCACTGAAACGCTTGGAGATCATCGGTATCCGGATTCTTTATGAAGTTAAACATGCTCCTCTGGTTTGAGGCGAAGGTCGTAGATATGTACTTGAGGAGCAGGGCCGCCATCGGATGGATCGGGAACAGCTTTGTGAGGGCCTTATCAGTGGTTCCAACCACAGCGGCGACCTGCCCGCGCGAAGATGTCATTCGGCTGTTGAGGTCATCGGATAGTCCTGCCCATTCGTCCTGTGCGGCAGGTCTCACTTTGAGCGCATGTCCAATCAGGTCAAAAGCCACGGAATCGGGCATCTCTATCTCGCGCCTGACGAAGCGATCGCGCACGATTTTGAACGCCTGATTTCCCTCATCGACAAGAGATCCAGACATATGGGTGACAATCATGAGGTAGAAAGGCTTCTCGTTGGATAGCTCTGCCAGTTTTTGAAACTCGTCAAGTGTTGTCCTGTTATTCTTGAAGTACGAGGAGAATTCGTCCCAAATGAAGACGATAGCCTTCAGCTTGTTTTGTTCGATAACGTCCTTGAGCCAAGCGGTGAGGTCATTCATACTGATGTCGAACGTACGGATGCCCTCCCTATCCGCCATGTCAAGGATCTGGCTAATGAGCTCGTCCGCACCCTGCTCTAGGTTCTCGAGGTGGGCGATAATGTCATCTGCAGTATTGCCTGCAAAGCTGCCGAGTCCCACATATTGAGGCATGCTCATATACATGCCAAAGATCTTCTTATGGGCAGAGATCCAAGATGCGATCTTTCCGCGAAGCGTCCTCTCTCCCCTGTAGTCGTACCCTAAGTCATGCAGCGCCTTCGTAACCTTTTCGAACACGGTCATAACGAGTTTACGGATGGAGTCCACCTCACCAGACCCATAGCAGAATACTGTGACGATATGATCGCCCTTGTGAGCGAGGAGCTTGTCCCTGAGGTCCGGCTGCCTCTTGAGGTTATCGTATTCGTCGAAATAGGAGTTAAGCTCCTCAGGAGAACACTCCAGGAGGCTCTTGAGCGTCCACGCGACCCTCGACTTACCGGTACCGTAGGCGCCCTCTATCCAGATGCCCTTCTTGTCAGTATTGGTCTCCCTGGCAAGCATGCGCTCGGTTGCGCGCAGCAGGTCAACGAAGGTCTCGTGAGGAAAGGTCCCGTCCCACCGGCTGTTCGGATCGCTGATGGAGTTAGGATTGATCTCCGGATAATAGTTCTCGTCGATATCAAAATAGTCGCTGTAGGTATCCACTGCTATTGCTCCTGCCCCACAAACAGCCCAAGAACGTCCTGCGAGGTCTTGTTCTCTCTTAGCTGTATCTTCTCTGAGTCATGGGTAAATGTCGCGTAGAGGTAATCTGGATAACCGGCAGAAAGCCCATAAACGATCTGTTTCACCGCATCAGAATCAAGGCCAAATAGCCTTGACGGGCATATTCCGTTTGAGACTATGCTCTCATCGAGCAGCCTGCTGAGCGTGAATTGGTAATATCCGTCACACGCCTCCGCAAACCGGTAAAGAGCGTAGAGGATAACCCTGTCATCTCTCAATGAGGCCTTGTACCTCGTCAAGCTTGTGATTTGGCGACCCTTCTTTTCGACAGCTCCAAAATTCAGGGCCGTGCCAAGAGGTAGGTCACAGAGCCTTCCAAATGCCTTGGTAATGGACTTGGCGTCTTTCTCACTCATTCCAGTCTCGCTGAGAAGATCCTCGAGGTACGTGCGCGGCATCCGTTCGTTAACGGGCATGTTGTCAATGTACCACCGAATCTGAGGGTTTTCGTAGACAAGTTGAATCAATATCAGTCCCCACGCACTATCGCTTTCCCATCCAATGCGCTTGGTGAGCAGCATAAACTCTGTGACCTTGTTCTTTTCTGCGAGCTGGGCGTCTGATAGGAACCTCTTGAACATGGAGATCTGCATCGGCCCAAGTGAGTTGTTCTGAAAGAACTCATCACCCCTTTCGTAAAAGTCACGCACCCACTCATATTTGGGTGCATGATCGGCAAAGGTATTGAGACTCTTCATGACTCTTCCCCCGTTCTTGGGCAGCTGTAATGAGTGATATAAGAGGCATCCATCTTCGATCTGGCGGCATTTCCCGCACTTCACACAGCGGTCATCTATATGTAGTCCACCCTCGAAGCTAATATAGCCATAGGGACAGTTTGCCTCGCACACGCGACAGGCACCACAGTAAGCCACCTTGTGGAAGATCTGCTTGACCTGCTTGGCGATAGAAGTCTTATTCAGCTCCGCCGATATCCGTGCGACGAGCCCCTCCTTCCGCTGCTCGACATACAGCGAGGTCGGAGGATCAGCCAAGGTCTTCATCCATTCGGTCCAGGAGGTCTTGGGCTTGGGGATGATCATGTAGAGGTACCCGTCCTTGACCTCCTCGATGTAGTTGGAGACGTTGCCCTTGATGTCACGTCCGTTCCTGCGGCTAATCCAGCCACCGTTTGTGACGTATGTGTCGATGGACTTGTCATCGATAAGCTCTCGAATCGTATCCGTGTATCGGTCGATCTCCTTACCGTACGCAGCGTGTCTGAAGTAGTCAGCCTTCCCGCCGCCCATAGGGCAGAGGAGGCATCCGGCGCGTGAGTTGCCCTTTTTATACGCGTCGTTAATCGGAAGTGCATTTGCAAAAATGTAGAGCCATATCTCAGCAGAGGACCATTCAAGAAGGGGGTTGAGCGAATACTGTCCACGTTGCTTCTTGCCATAGTTCTCATATTCGTAATCGGCACGCCTGACGCTCTCCTGCGCCCGAACGCCGACGAAATCAGCACCTACGTAGTCGCCCTTTGCCAACACTTCGCGAATTTTCAGCGTTTGGGGAGCAGACTTGTGCACGGAGCAGCACCACCGCAGTACGTTTGATGGAGGCCCGAACAACCTCCATGAATCCATCGGGTCGAAGTGGCTACGAGCCCTATGGAATTCGATTCCGTCTTTCCTGCAAATTGCCTCCTCTTGGTCAATGATCCGATATGTATCGGAAAACTCCATTCCGGTATCACCGAAGACAACCATAAAGCTGCTGCGCGGAAGAGCTCGCTTCACCAGTTCAAGTAGGACAACGCTATCCTTGCCACCCGAGAACGCAACGTGAAAGCAGTCCAATTTATCCTTATAACGCTTGTAGTAGTCATAGATCTTCTTGACCGTGATCTGCTCCACGATGGAGAGTGCATCCTTGTTGCGCTCGACCATTGCAGGAATATCAACTGCGAGAAGCGTTGTGCCCTGCGGCAACGCGAGGGTTGCGTCCCCATCATCAGCCTTAGTGTGTACAAGCTCGAGAACTGGTGCCTGGCAAAGTGCCCCACCCTTGATCTTTGCCACCTTGGTTCCCCGGTAGATGTAGTTGCACGCTTCCGACCACATGTACGGAGTCTCGTTTTGCTGGTCAAATCGCCAGTATTTGTCCATGCCCAAAAGGTTGAGTTCAGCAGCATAGACTGGCCTCGGTTCATTGGACAACTGTGAGATTCGCTCACCCAGAAGGAGCCCGCCGGTCTCTATGTCATAGGTATAGTCGTACACCTTGCTTATCCTGCGGCATCGCGAAGCACTCGAGCCTGCTCCGTCACTTTCTTGACAAATATCGTCTTCTTGACCACGAAACCGAGTCTCACAAGATAATCGCCAACTGCGTGTTCTTCCAACTTCAAGGAGCTGTTTGCGAGTACCTGAGCAACTACGTCATTGTAGTCTCTGTCATCATTTGCGAGACAGATGACTCCCACGTTTGCCGTTCGAGCAGGCGACCCCCCTTTGATGCAGTAGCGCCTACTGAATCGTTTCACATAGCTCTCGAGGAGGTAGAGATTCCACGGCCGCCCAACGTAAGGAAACGAAGTGAAGCTCGTTATCACCTTTATGGGGGCGACGCCCCCACTGACGAAAAGTGCCAGGGCATCGTCGATAGCCTCCACATCGAAGTCAATGGTACTATCCTTCACGAACGTATCCCTGTCAACCCGAACCATCGTCTCGAAAGCTACGGGCAGCATTGCATTGCGTGCTTTCCCAAGCAGCTCTGCCTCAAACTCGTCCATCTCGTCGACGGTCATCGCATCGAGAGTCAGGCAGCGTGCCCGCATCACTTCATTTCTCGAGAGATTCCCGCCCTTGGGCAAGATGATCTGGCCTTTTCTGTCAAAGGTCCTTGCGAGCACTTGTTGATACAAGGCGTTACGTATCGCCATTTCGGAGAGCTGGGGGTTTCCACCAAGCGACCGAGTGATGTCGATGGTACCGAGAGAGGCGAAACCCTGCGAGGTGATTTCGCCCGCCACGAAGTTTGGCGCCTCCTTCAGCTCCAAAGGATCCAAGTTGATGCGACTTACCATCGCATACTCGTTACGCTTGATCAGGACGAACAGCTTGCTCGCTGAGAGGGTAGACTTTATCTTCTTGTACGGCAAATACGGCAGCCTACCCTTGAGCTCATCAGCGCTAAGCTGCTCATCGTCTGCAAAAGCACGCAGGATCTCATCCTCTATGCTCACGCCCCCTGTCGTGACGCAGTAATGCTCGTTGTAAAGCAATTTGATTCCCGTAGACCTGATGATCTTCTCTAGAATCTCTGCAGAGTTGACCTTCATATCTGAGTAATAATCCGGGTTGGCCTCATAGAGCTCCTGATAGTAAAAGATCCTCTGACCAGCCTTGATTGAGTCCTCAAGCAACTGCCGGACCGCTTGTTTAGGCTCCTCTGCAATGAGATACGTCTTACCACTCCACTCAATCCCGCCGTTTTTTAAGATCACATCAGAGATCGCCTTTTTGCTTGGCGCTTCCTCATCAAAGTTCTCATGGTACATGTGAGCAAATCTCTTTATATCAATGGTCGAGTCAAGACGTATCCCATTCGGATAGCCCTTTGACAGCGTATCGAGTATTCTTCGTTCAAGACCCGGGTCGATCGTTCGAGTGGCTTGCCTGGCGCGATCATGACCGTATCCGCCAAGGCGCGACGGGTTGCCCATAGCCTCTATGAACAATATGAAGCGCTCAAGAGCACCGCTTAGTCGGCTGTATCGCTCATTACTATATGTAGAATTAGTGTCTTTTAGTAGCATTTGAGCGTTCGTTTTGATCTCATGAATATTCGCGTTGCCGTAGAATATACGCCCCTGATAGCCGTGCGACCTGGCAAACCTCTCAACGGCATCGATTGCAGATGAGTTGCTCACTGCCGCATGCTCCGTGAGGCCCTTCGACATCATCCACCGCTTGAAGCCATTTGCATCTATTGAATAGACTCGATTTTCAGCTGAGTCAACCTCATTGGAACGAGTGGGGAAGACCTCATGCTTGGCATCAGTCACAGGTGACACTGTCGGCCTGCGAGTACTGCTACGCCCGCGCAGAGCCGCAGCAATGGCAGAGCAGAATCTTGCAGGGTCACTTCGGTACAGCCTGACAACCTTTTGAAATAGTATCGGGGGATGTGGTATGCCACTCTCGCCATCAGTCATGACATACTCCATGACGCTGTACTGGTAGCTGATGCCAGTGGTGTTGCGAAACGAGTTATCAGTTTGGATCCCATGCAGCTCAGCACGCCGACGAAGAGCTTTCGAGACGTACTCAACAGCTTGGGATCGTGTCAACCTCCCGTTTTCGACTTGAAGGTAGGCATAAAGCAGTAAGGCTGCCTCCTGTTTGTCAAAGCGCGTTCTAACAGCCATTCCCCACTTCCAATTTAAGAACAGGCCCCACAAGGAAACGAGCTTGATGAATATCGATTGATATTCAATTCACTACTGACAGATTCCACGGCATAGCCCGTGTCGCACGTAGGATCCGTTCGAATACTGACGCCCCTCGCCTCGATGGCCTCTCCCTCCTCGACGCCCAGCTTACCGACTACTTGCCGCATCATGCCATGCGCCTCGTGCTTCCCTCCGATGTCATCTCTACCTACCAATCACATCATAGCAGGTACACAAAACTCTAACGTCTAATCCTTAAGCTCTCACATAACTTTTGATATGGGAGCTTGAATGAGTGAACCGCAGCGTACATCCGAAACTTGGACTCAGCAAGCGGGCTGTACCCCCAAGATCGAGGCAAACAAGCATAGGTGCTATCCTGGAGCGCTGTGCCTCAACCCCACCTGTCACCTCCCGTCTTACGACAAGAGAAACACCGCTCGCGAGGAGCTGGCACATCTCGACAAGGGTGCGCATGGCCAACGCCAAGTGCAGCACACTGCAAAATCCATACCCATTGCAACACACTGCACTATCTGCGATACTTGCAGCACATTGCACAAGCCTAGGCACAGGACGAACCATGATCATATCCTCAAGCGTCGAGGCGGGCGCGCTCATAGGCTCGCTGCGCGAAATGCGGAGCCTGAGCCGCAGGGAGCTCTCTGCGGCATCGGGCGTCCCCTTGCGAACCGTGTACGCGGCCGAAAACGGTGAGCTGCGCAACATGAGCATCGACAGGGTCATCTCGCTCCTGAGCGCCCTTGGGGCAAGCCTTAACGTCGAGGTCGAGGCGACGAACGCCGACGAGACGCGCGACGACGAAACCAACATCCTGGTGAATAAGGCGGCACGCGGGGCATACGACCTGGCAGACAGCTGGGGGATCGGACTGTGAGTAGCGGCATCCGCAAGATGGCGCTCTACATTGCGGGTCGTCTCGCCGGGCACGTTCGGCAGGACGAGAACGGCGCCCTCAGCTTCTCCTATGCCCCAGACTATCTTGGCGCTCCGGTCTCGCTCTTTATGCCACTCTCGCCCATGACGTACCGCCAGCACGTGGTACGCCCCTACCTCATGGGCCTCCTCCCGGACGATCCGACCGTTCGCGCCGATATCGCGGACAGGTATGGCTGCTCGGGCGAGAACCCCTTTGCCCTGCTTTCGCACATCGGCCTCGACTGTCCCGGAGCCGTACAGATCGTCCCAGAATCGGAAAGGGCACTCATTGACAACCGGGTGGGACACCTCATTGAGCTGTCCGCCAAAGAAATGGAGGACACGATCCGCGTCATGCGTCTGAGATCGTCCAGCCCCTGGCAAACCTCTAACGGGCAATCCGAGAGATGGTCCCTGGGTGGAGCGCAGTCCAAGATCGCGTTGCGGCTGACGCGAGGCACATGGTACCGCTGCGAAGGGGACGCGGCGACCACGCACATACTCAAGCCAGGTGTGTCCGGCTACAAGAACCAGGCGCTCGACGAGCACCTATGCCTACGGCTCGCCGCCTCGATCGGCCTCCCGGCAGCTCACACGTCCTTTGTGTCCTTTGGCGCCGAGAGCGCCGTCGTGATAGAGAGGTACGACCGCGTGACGGGCGATGACGGTTCCGTCACGAGAATTCACCAAGAGGACCTCTGCCAGGCCCTCTGCGTGGACCCAAGCCGCAAGTACGCCGAGCAGGGAGGCCCCTCTACGCCGGATGTGCTGGCCCTGCTGGCAAAAACGGGCAGACACGCACCGGCCAACCTGAGGACGTTTACGCTCTTCCTGATCTTTAACTACCTCGTAGGCGCAACCAATGCGCACGCGAAGAACTACTCCCTGCTGTTGGGCACGCGCGGGCTCGCAAGACTCGCGCCGCTCTACGACGTGGCGTCCATTGCGCCCTACCAGACGCCTGCGCCCAGGCGCCGAAAGCCCCTGCGAGCCGCCATGTCCATAGGAGGCGAGAACCGCTTTGGCAGGCTCGGGCAAGGGCATCTCCGCAAGCTTGCCGCTGACCCCGCCCTTGCAAACAGCGGCGTAGGATACGATTGGCTCATGGCGTCCGCAAAGCGAATGGCAGAGATGGTACCGGGCGCACTGCGCGAAGTCGTGCACGAGTCCGCCAAGGATGGACTTGCCGGAATCGAGGTCGTGGGCCCGCTTCTTGAGCGGGAAGTATCCGCAAACTGCAGGCGGCTTCTCGAGAGGCTATAGGCAGAGGCCGCACCGAGGGCCATCACAGCCATCTGTTGAAGGGCCTGTCGAGACCCACCCTCCCTGGCGAGTTCTCTTATCTCTGCGGGTCAAATACGTCGGCGGGGTGTCACCTGTCGTCTTGATTGTCAGATTTTTTCCTTGAGACAAGTCTACCGGACAGATGGTTAAATTTGGGAGTATCACTACCAAATTTAACCATCTCATTGTTGCGTGACGCACTAACCTCCAAGGAAGGGGTCACCTCATATATATCCACCGCGAAATCGAAGGCACAGTCGATGCCATGCTCAGCCAAGGCAAGATGGCGCTGGTCACCGATGAGCGCCAGGTTGGCAAGACGACACTCAAGGAGCACCTTGGCGATCGCTTTGGCTATGTCTCGATGGAGACGCCTCGCGACTACGTCCTTGCCAAGCAGGATGCTACGCTCTTCTTCGAGTCGAAGAGCCTGCCCCTCATCATCGATGAGGTTCAGCGCGTTCCCGAGTTATTCTCATCAATGAAGTGGATTGTCGACCAAAGCGAAGAGAAAGGTCGCATTGTCCTTACGGGATCTCAGGCATACCACCCCATGAGCGCGGGCGCGAACCCTCTCAACGTGTGGTTTTACCACGATTCCAAGAAGCGCGAGATAGACCCGGTCATCCAGGAGGGACACGTCCTACACCCCGCAGAGATAAAGACCAACGTAACGGTCGGCACGGACGCCGTCAAGAACTTCAGCTGTCTTGAGGCCATAGAGGGCTATGGGGTCGGATTCGGACACGTCATCTGCCAGACGCAGGAACCGTATTACGTTACCAGGGGAGTGCAAGCCATACCCGTGTGGGCGATATAGCTCATGGGGTACGTAGTTTCTCTCGCTTGGTGAGGGCGAAAGCAGCATTGGCAGTCGATAGCATATTGCCAAGGCATCGCAAAACGACGTTTTGGTATGCCGCAAAACGAAGAAAATAATTTCGCAATACGTCTTCTATACTGTTCGCAAAACAGAGAGATACAAAATGCTTCGGATCAAGATACGTATCTCGCCAGTAATCGCAGACACCTTCCTCGTCCATGATGCTCAACTTGAGTGTCCATGCATAACGGCCTGCAAGGTATGGCGGATAAACGTCCAGTTTCTTTGCAATCCTGTCTAACAGTTCAGGGCGTATCCCTTCGGCCTTGATGGCCCGACGGATCGTCTTGTCGGTCTTGCCAATATCCCTGTCTGCGCCAAGCCTGCGGATGCTCCAGCCCTGTTTGTGTATTACCCATTTGAACCATTCAGGGTCAAGTTTCTCGCCGGAAACATCGCTGTACTCATTGTCCATGACCTCTTCCTGTCTGTCGCGAAGGTCGCGCTCGTGAGGTGCTGGCGGCGCGTCAGCCCGGTGACGCCGTCCCAGGGCGTGAAGCCCAGGCCCACGTACTTGCCGATGGCAACAGATCCGCCCGGACGCCACGAGCTCGCGCGTAGGGTCTGGCGCAGAACTCGCGGTGAGTACGCCCTCGCCGTTCGCGTAGTAGTGCGCCCAGAGCCATGTGCGGTTGTCATTGTTAGGGTCGGTTAGAACTCCGCCGGCGCCCAGCTTGCAGACGCTTGCACTGCTGGTCGTAGAGGGTACGAAGCCGTCCGTTCCGCCGACGAGACGGTTGCAGCTGTTGAACATGAGGCTGCCCGAGAGCCCCGTGTTGCTGAAGCTCGTAGCGTAGATCGTCTCCAGGCTACCGCAGCTCGTGAACATCTGATTGGCGCTTGTCACGCCGGAGAGGTTCTCGGTCTCCACGGTCACGCCGGTGTGGCCCGCGATCTGCGCGAAGGTGAAGGCATCGGCCTCGGGCGCCACCTGCATGCGTATGAGCTCGGCTCCCGCTTCGATTGAGCACGCCGGAGACGCCCGCGCACTGGTATACCTCGTCGATGATGGAAACGTAGTTCTTTGCGAATGCGATGCTGTTGGACATGGGCCGGCCCCCCTATTTCTCATCGCTGTCGTCCAGGCCGGCGAGAGTGCGGCAGCGCCTCATGGTCTTGCCCTCATCTGAGCTCGTGCCCGCATTGGGGAGCCCGGTCTTGCCGCCCTGCGCCCTGGCGGGAGCGTCGGCAAACAGCCAGGACTCGGCCTCCTCGAGCTTGTCGACGTCGTTTTCATGCTCATCCAGGATTACACGTGTGGCCTTCACGTTTGCAGGTTTTTCTCTGCCGATGCCCGCTCAACCGTTCGTCGAAAAAGTTGGGTATATTATTGATGTTTTCTGGAGGTTTTTATGGGTGGTAAGATGGCATATATAGAAGGGCTAGCTGATGCTGGGCAACGTCTTTATGACGCTTATTCCACCGTCATGACCGAGGCCAACCTATCGGGCGTTCTCGACGCTATTCTTGGTGCAAACCGCTTCGACTATCCTCAGACAACTGCTCGCGACCTCATAAACCGCATCGTTCTTGGCAGCTACCCAAACGAAGCAACCATCAAGGCGAATTTCATCAACGGCATCCTCCTGCCGCAAAGCCCAAAGACGGTCTCGGTATTTGAGCTTCCCATAGGCAAAAGCCGCGTGGACATGTGCAAGATCAACGGTCACAGCGCGGCATATGAGATCAAGACGGACCTTGATACTTTCTACCGTCTGGAAGGCCAGCTCAAAGACTACTTCGACGTTTTTGAGACCGTGTACGTTGTGACATCGGAAGCACGGTGGCGCGAATTGCCTGATTACGTTCCCGAGGCGTGTGGCATCTACTCCTATAGGCAATGCGAAGATGGCACCTACAAGTTCTGCGCCCGCAGACGGGCCATTAAGAGCAGCGAGCTTGATTCTGAAAAACAGCTCTCCGTAATGCCCAAACAGTTCCTCTGCTCCCTTTTCGGAAAGGAAGGGAGGAGGGTCTCCAAGACCTCGCTAATCCGAAGTTGCCTAGAAGAGCACGATGGACGGGAAATTAACCATCTCTTCAAGCGGTATCTCCAACAGCGTTATGGCTGTTACTGGAATAGGTTCCGCGAACTCCAGCCGGAGATATACGAGATTGACTACCAGTGGTTCTACCGTTATGGACTTAGCCCGCAGGCAATCTACTAGACGAACCCCGGCCTGCTCATTGCGAGCTGTTGGATATATCTGACAAGCGTGTACTTTATCCACTCGGCGAAGGTGTAGCCCTTTTCATGTCTCCGATACTTATCGGTAATTGCCGCAAGGGCAAGACAGGTATCGTCTTGAGCGAGCTCAGTATCAGCCAGCATGTGCTCGACAACATCCCAAAAACCATTAGGACCGAGGTCGTAGTCATCCTTGACATAAATCTTGAATCCATTGACCTTGCCATCGTACATAATCGCAAGAGCACGACCCTTATTCGCGCCTCTGTCAGGCAGGTTGTCTCGAAGTCCGCCATAATCGCCCACGCCATCGAAGCCATAGTTTCTGTAGACATCGAGATGGGTGTTATCAATAAGATTCGTCACCTCTCCGTCCTTGCAGTTCTTGAAGTCTTTGCCCGTGAGCTCCCTACGTCGCGGCGAGCAGAGTGCGACTGTTTGGGCAGGAAGGTTCAGGTTCTTGAGTCTCCTGCATTCCACGGGTTTGGAGCGGATTGGCTGCTCGTTGAAGTCGTAGATGAGGCAGTCTCCGTCACGCAACACCTGCTTTGCGACATTTTCGTAGCCATCTATATCGTCGAATCTAAGTGCGATTCTCTGAGACGGATTGTCTCGTCTCAGGTCATTGGCTAGCGATACGACCTGTTCAGGCGAGAGCACGTCATCCATTCCCTGCTTTACAGCGATGACGGGTATGAGGTGCGGATAGGCAGCGATGCCCAAGACCTTCCCGCAATACAGATTGAGGTCCCTATTCAGGCGTAAGACAAGCTCAATCTTACCCGCATCATAATGGTATTTACCTAGGAAAGCGATGATAAAGTCGCCGATCCCGTCCCTTCGGGACCAGCATGGGTGATTTTTGACGTGAGGAGGGCTCCAACGCCCCCAAGCGGGCTACGCCGGTCTCCGGGGGCCATGCCGCAGCCTCCCAGACCATGGCGGGACGGCCAGCGGTAGGCTATGCCGCGGCCGGCGCCCCACCCTCCGCCCTCCGTCGCCGCTCCTCGAGCCTCTCGCGTTGCAGGGCTATCCTCTCCGCCGACAGCGCGAGGGGCGGCCCGCAGAGCCGCCGTCCCCGCCTCGCGATCATGCAGCCGGCTGCGGCGACGGCGGCGAAGGCCTGGTTGGACACCTTGGCGAGCCCCTTATAGCGCGTCTTCCGCAGCCCGAATATGTCCTTGACCCAGTGGAAGACGTGCTCGACGACACTGCGGGCGGCCGACTTGGCGGCCTCTGCGACCAGGTCGTCCTCGCCGACCTGCGAGCGCCTCTTGGCGACGATCCACTCGACGCCGGAGAGGGAGGGGTCGCCGGCGACCTCCGGCCTCCTCCCGACGCCGACGTAGCCGGCGTCGGCCCAGACGCGCTCGTCACCCTCGCGCACGAGGTCGGGGACCTGGTCGAGGTCGTGGACGTTCGCGGCGTCCATGCGCACCGAGTGCGGCACGCCCGTCTCGGCGTCCACGCCCACCCCGAGCTTGTACCCGAAGTGCCAGTTCTGCCCCTTCTTGGCCTGGTGGGCGTCGGGATCCCGCGCGCCGTCGGCGTTCCTCGTCGACGACGGGCTCTCGATGAAGGTGGCGTCCACGATGGTGCCCCGGCTCACGGCGAGCCCTCCGTCCGCGGCGGACCCGAAGGCCGAGGAGACCATGGCCTCGCCGACCCCGCAGCGCTCGAGCAGGTGGCGAAACTTGCACAGGGTCGTGGCGTCGGGGACCTCGAAGGGCGCCACGCCGACGAAGGAGCGCATCGTCGCGGAGTCCCAGACCTGGTCCTCGCACTCGCGGTCGGAGAGGCCGAAGCAGACCTGCACCATGTACATGCGCAGCAGCACGAGGTCGTCGACCCTCGGCCTGCCCATCGCGGGGCCGGCCCCCCTCGCCCCGGCGTCGGCCCCGCGGGCCTCCCTCACGAGGGCGAGCCAGGCGTCCCAGGGGCAGGACTTGGAGAGGCGGTCGAGGAACCGGGAGCGCCTGGTCTCGCGCTTCCGTCCCATGCCCATCTCGACGTCAGAGAATGTGAGCTGTGCCAT

Protein sequences of DBSCAN-SWA_5

>NZ_CP012069|2222725:2279035|2244392_2244857_+|WP_050340949.1|transposase|DBSCAN-SWA
MAGEGGEPRGGRERRRALSKERPGTARACATREASRATCDCGARDDAGSGPNALRGRVTRPDVPRTRTVARTMRERRAEIPGHSGHGPANAVPGGTSSAVQSAKRQARGLGNLEYLETIIYPRLGKLRFPRRPSVLPTKNREEPNVLCRNLHIY
>NZ_CP012069|2222725:2279035|2224646_2225891_-|WP_157051485.1|integrase|DBSCAN-SWA
MERSKGMDIKMLGGAADALVDRLRSDGYSDEMVRNARWVLGNFAKWCEREGVRSVNREEAARFLLAQFDLPIDERDVTPAQCVIRKPLLTLLELEETGTYLKSHQRHPGPEPPPEQFAGAYAGYAALVGSSGLAGSTKALRLWRVRRFLLFLDSRGVRKIGDLTVADVHAYMGEPGRSPHENKRDGYSLRKALDWMGEEGLIAFGGRDAFPVVRARAYSPLPSRYTDEEVALILGSVDVATPAGKRDMLVLSLFAHYGMRCGDVAALRFADVDWCSGRIAIVQAKTGLRLSLPIVDGVRFPLLDYAGNARPRSNDPHVILTTHAPHTPYKSGSSFHRMVTRAIDRAGVDRSGRRHGGHALRHSAASGLLAAGVPLPTISSVLGHASTSATEAYLSVDEEGLAAIPPEVPHVRGW
>NZ_CP012069|2222725:2279035|2233195_2233393_+|WP_050340926.1|DBSCAN-SWA
MLDRSYTDGGWWLFDHRINLTDEVFALAGEEAPRRWMRVRDVEALLEKGKDPLDLRHRTGDVHLG
>NZ_CP012069|2222725:2279035|2259442_2260909_-|WP_050344523.1|protease|DBSCAN-SWA
MTDKLKTYFDDMVVYKDLRTSNFFSALSLPSFMRDWLLRRFEDESGHFDNDELTEFVRRSIPRKSDWIAIKSRIVKDNERVKILAKISIEVDVRSGEVSFSLPDFGLTAKETIIEDFVWEQAKDDLVSGREVWGMLELGYRPPDDEMTPRQPGKIRLVSFKNFRPYSINLDFYKGVRNQFTTDEWIDVLLGAIDYNPRGYRSEEEKLTMLTRLLPFCEKRLNLIELAPKGTGKSYLFGRVSRYGWLSSGGVMSRAKMFYDISRHTEGLVAGHDFITLDEVQTISFTDVDEMRAALKGYLESGVFTVGSYEGTASAGMILCGNISKGVMDQDGTTDMFQELPSVFHESALIERFHGFIKGWDIPRMNDDLKISGWALNSEYFCSILHELRSDASYRAIVDKLVLVPDAADTRDTEAIKRITTAYLKLLFPNVKRPEDISPRDFSRYCLRRASKMRATIRMQLGLMDVEYRGKDIPDLKADSSYYEKRSL
>NZ_CP012069|2222725:2279035|2234799_2235795_+|WP_050340930.1|DBSCAN-SWA
MLKRAQRSGADEESTEIITRYKQKILEALSNYNKADIAQCYTIIEGLIKDIGHNPLAVDTVKQSSAFPGKLGSEVQFFRGRIGNPSCSYVAKDMLHLPKSRRVKTGNYRFSIPGNPSFYLANSSYGCWIEIGFPSYIEFNVAPVVLDETQKVFNLAVSVRDFDSMNEFENDRVHCWLKLLMLKIATSYRINEDKRTFKSEYIISQAVMISCKRMGYDGVAYFSRRVSDEAFALCAINLALFVDYDDGEYSPLIKHIKMDRPLNYFVFKQLCQSLKYGECNSSLRTVNNPYITNIGDYSKQYPYRETEFFEFDKFLFASWKKDESPWGVPVE
>NZ_CP012069|2222725:2279035|2236233_2236521_+|WP_157051492.1|DBSCAN-SWA
MIAMIDEGMRRKLREMGMGEIVEALGLQEADRTCMGMPLNERVRMMVDHAHEGKHSASVRRLMQRARLRFFDADPSEMIYDGRCIDGVLIREALT
>NZ_CP012069|2222725:2279035|2238917_2239904_+|WP_050340941.1|integrase|DBSCAN-SWA
MPRHRLSGTPPGRRDPGPNTIASYRDASGLPVDYFGDHGKEPESTSTPDPGRHAVRGFLEWPAARGNSDGTADRRPRATGALAGCARGEGPARLLQYQQVLAMRQRKGKSDAMVTPGRDGLAAILRDPGMSTSRGRRDTALLTVPCDSAARVSELCGITLRDLRLDDPAVVTLRGKGRKVRTVPLMHATAGLLREYVSEAYPGLGPRDLDKPLFPNPRGDHLTRAGVADILARHADGARKSGADIPEGVSPHSFRHQRAIDLLESGVNLVYIRDLLGHRSVTTTEIYATVSTARKRELLEKAATAPRVGEYPDWTADKDLMAWLKALC
>NZ_CP012069|2222725:2279035|2242769_2244317_+|WP_050340947.1|DBSCAN-SWA
MYISHDVVDGNEYATVVRSVRDGARVTKEDRVYLGRVVDRARGVYRSKARGLFSYDLATGEFGPAPEGVEGPRRRNARAARPTLAVSFGDAFLLDSFLRSSGLMACADACGHAEPDTVRALLAFYVLTGLANRHAGDWWELTYARLLYPRARMASQRAGECLADLGSEDAKRRFVGEYLALVGRRREAAAGGRADGILIDSTGLPNSCRLPVTAVSNHNGEVSEEVRLIYVAQRDTGMPLFFRHVAGNVIDVSTVTRTIAELRAMGVDTRFAVLDAGYHANASADALMGARVPILARMRPNLRAYREVVAGHLDGLEARENAVMHNGRLACVKCVPCALGSRGDRRGYAYLCLDAAMRRELERDAARRAAEGGLSGAEAHDSMASRGVFVLAGTRRIARGKLLPLYYARDRIEKVFEIAKQGGKALPVCVRSEETFRGHLLMCLVATAAIKMMSDVLASRKTSLTVESMLRILHEQHAIEYDGRLVTTEPVRKMNEAYRAFGIRCPDTIGLPVVG
>NZ_CP012069|2222725:2279035|2248117_2248309_-|WP_050340957.1|DBSCAN-SWA
MLPPAGGEDGRYGLAGSKTAVALGTEDREMPGRLARMRTAQAQAQAQAAARARIPLLRDSGET
>NZ_CP012069|2222725:2279035|2244878_2245580_+|WP_050340951.1|DBSCAN-SWA
MENAHDIASGYTTSQAARLLGVGRHEVARLVRNGILRARKTDSGTLAIDPGSVHTHEALSQFKGRPWSPQTAWAALLAIGGDDVSWLEYHKRRRLLLKLREIGAGELIWLARNRMEARRYLVSPSFEDDVRKALVATGMASVLANDLGLASTAPVLDGYVVGMTAEELEHDFFLVEDATGSCTARFASDLPDSLADATEMPAAVVAADLAMSVDARERRCGLDYLEGLLDGMR
>NZ_CP012069|2222725:2279035|2250494_2252276_-|WP_050340962.1|transposase|DBSCAN-SWA
MAYFLKRTRNKKGLYLQIYESHWDPGRGHTVNRSVRAVGYEHELRESGIADPIAHLRSEVDSMNAERRAERERGRVREISDAPSERHLGHFALKAIDDSLGVRGDLAFLQVPSGFRFSLADLLSCLVLARAVAPCSKSRTFHDVLPQMEGVEAGFTLDQLYDGLAYLGEEYEKVVEIYNARVGGLFGRDTTTSYFDRANFCFEIGREDQPGRKGPSKEHRPEPIVGMGLLLDADCVPIAMSVFPGNESERPQLKRCISQLKERNAISGRTVRVADNGPDCADNVVDAVLSGDGYIFSKSVKALPARERAWALSDEGWQDVPDGRGGVAFSHKASTGDFEYGVTDAGGRRRVVALPERRVVTYSPALARKQTREIDRQVEKARALRLAAARRSEYGDSARYVTFEPVDGEGEVREDTRVVATLNHDAIRKARSVAGYNMLVTSETSMPPREVYGTYHRLWRIEESFRVMKSELDARPVYLQRQSTITGHFLVCYLAVLLVRLLQVKVLGGRYSSEDVMGLCRGLDVCQASDRRYVNVSRRTPIIEELAARTGLPLLHFNLSKGDVKAISSCTLGMLRGEGKVSPPNGRRCKGAS
>NZ_CP012069|2222725:2279035|2240608_2241442_+|WP_172674478.1|DBSCAN-SWA
MARPGRPGTSPSAPGPGARAGARPAVSRCARRGSPRRPPGRAAREGAAAAGRPTRELVQLARAGPPGTAGPVLLPPDAGGARLLFQVISESHGRQSLVTTTNPGSGRWGAALGDDRTAVAAVGRVCHHGRLPRSGGESRRAGHAPVSGKGAARRRRGMASCPGAPVATSPPPVTPDARRVTCPTTPCPRQGATDSPVTGQSTCGWRRCAVTAPMRWGSSGARPSSDRMASPRGHRTGDPPVSVGRPGREAPDLGDRRPNPVRTLLKSWCDFCSILTV
>NZ_CP012069|2222725:2279035|2225937_2226648_-|WP_172674477.1|DBSCAN-SWA
MANVRKPWLTPSQQVAHLKSEGVGFRICSERDAEEYLKSNNNYFRLKSYRANFARVEGGPNDGKYIGLDFGMFTDLSIIDMRLRNEMLPITLDVEHFSKVRLLGKMEERRADGYKIVRDFLQQQDDLGTHPYDEIDKGKSSPYTSGLVERRPDYGFPAWELIEVISFGRFIHFYKFCADRFDNRRMRNDFYMLQSVKGLRNGCAHNLCANAHKLCYRRLSVMSSLSRLTGSEACTT
>NZ_CP012069|2222725:2279035|2227904_2228279_+|WP_050340919.1|DBSCAN-SWA
MELYDASELYPGFEYPAGIKRVVELGLTYLGWWWILEACFAGDYTRNMAGRYPDRRLIPFAKREDCDDVACFEVGRPGKVTIIHDFANPGWEQREEYGDFWSWFEAAVLDMIAREREEEAENGL
>NZ_CP012069|2222725:2279035|2274155_2274749_+|WP_083443946.1|DBSCAN-SWA
MYIHREIEGTVDAMLSQGKMALVTDERQVGKTTLKEHLGDRFGYVSMETPRDYVLAKQDATLFFESKSLPLIIDEVQRVPELFSSMKWIVDQSEEKGRIVLTGSQAYHPMSAGANPLNVWFYHDSKKREIDPVIQEGHVLHPAEIKTNVTVGTDAVKNFSCLEAIEGYGVGFGHVICQTQEPYYVTRGVQAIPVWAI
>NZ_CP012069|2222725:2279035|2248573_2249467_+|WP_157051493.1|DBSCAN-SWA
MTHFDDIYEIAADNYGLVTFAEAREAGATGGELGRWVAQGRLERRGRGTYRLVRRTPTPLRPLRRGRRPRGARLRRVGRLRPRDAGPRLREPARRLRRVREARAKGAPRMGEARGRARGRAHRLRGRALPGAPRGDPRVQGARPSRAARRRRAGCPCARAHHQGGGGRARGGHGMSGRKRPNSRRNLDIARAFHGHDYRASRDIREASMPPMRSHRRPAHTTPPTQAPLYAARRPRSNHAEVFPRAATTQDPTPSRLVHEDSPTARSARGPRKRTLRPSRHSSSALIDSASTYSNVT
>NZ_CP012069|2222725:2279035|2274750_2275227_-|WP_157051495.1|DBSCAN-SWA
MDNEYSDVSGEKLDPEWFKWVIHKQGWSIRRLGADRDIGKTDKTIRRAIKAEGIRPELLDRIAKKLDVYPPYLAGRYAWTLKLSIMDEEGVCDYWRDTYLDPKHFVSLCFANSIEDVLRNYFLRFAAYQNVVLRCLGNMLSTANAAFALTKREKLRTP
>NZ_CP012069|2222725:2279035|2260918_2263042_-|WP_172674480.1|DBSCAN-SWA
MSDALKRIAAYRKSDMPYPFFVLADGNTEYSSVVKALNGLSIVRVSDYCRTDSFPDVDRLITDIKKIESSTILLGVGESIALGGSSTLLGKLRDLLLPHKLIVVCRGIREDIRRINEADRKFNERRYTSVQSILDYSVVSIDESIPCDADKGFKRFLSHLEKGLHGEVRVKTALSLKNVQKICSCHTLLEKDGRITGVDESVLPEECWREFLEDDSLEESGYREWRFYLNVLINGTKNPYLQLVIEKSPDYETYQKMIARAILHVPCESPQFPELYSERKQLLHDASESYMALYVAETKQKGKQRIHYLTDNTVIERDAIIESICESQAIPPDLKTIYPALGKYLCDYAFACRNNDLFNRYFSRYKRQKLMNTIESSFLDEVVMLAKDGNRAYNALDTRNAIVEQTEGEGAQLYWVDALGVEYLGYIQQRSHDLGLSMRTHVARASLPTLTCMNKSFYEEWKGDKTSRKDFDKLKHNGEDRFNYESEKLPIHLVRELSILDEVLEFAQTQLSARKYRKIVIASDHGASRLAVIANSEAKWEMTTKGEHSGRCCPESEIDEKPDCATAENGYWVLANYDRFKGGRKASVEVHGGASLEEVLVPVIELSLRDASVEITCLTKVAYASYEETPEIELFSTSHLANVTVRLNGRVYEARKVDENRHIVRFDGVTKAGTYTCEVYEKDDRIGVAEFEVQKRSATTNDDDWFM
>NZ_CP012069|2222725:2279035|2226812_2227277_-|WP_062393132.1|integrase|DBSCAN-SWA
MRADTRRAMDEMGMDVGDPCILGTQVSDSRPYNPMQLGKDFSAFCRMDGFSCMFHDLRRMFATMMIAGGCDVRTVASYLGHASVSMTLDTYAGIDPEAKCAAVGKVGESFDVDMSAMGFDGPERSVGNQHERAHVHRRAAGGHARRGQAEGGRP
>NZ_CP012069|2222725:2279035|2252593_2254192_+|WP_172674479.1|transposase|DBSCAN-SWA
MSRNKRILMLLAKGGVSQSGIAAALHVSKRDVSAGARALREHGLTFGAVSSMDADVVDDLFFPRERRGPNGACLQPDMESLVERKKRNRKLPVRLFWIERCEQAAAEGRLAYAYQTFCEMFAGVAERMGATRHFIHEAGAKCYIDWAGDTAHLTDKLLGTKTKVHVLVVVLPFSGRFWAEGFCDMKQRSWQEGQMHAFEEFGGVPRMWVPDNAATATNRAAPQVTLVNEEYGRLADHYGAAIVPARVRKPRDKSVAESVVGLVERWIVSPSNEMAFYTIDELGEFCADRVAWLNSRPFSAKDGSRDSVFEEEERPHLMPLPAERYEMCEWRSPKVAPDYHVVVDYMRYSVPCRLVGEQTDVKMTSSTVTVLHGGEVVAVHPRLRGRKGQYSTIDDHMPENHAALDNPWSPERFTSWAKRIGPETGIAIGRVMESRVIVEQSFVSCRNILGLSKTYTPALLERACARMNAASALPSYTGVKNTILAIRAADVELGAAGRRTQPAEPGELVDRARSAGRLRGADAYKRGGDRRC
>NZ_CP012069|2222725:2279035|2258122_2259280_-|WP_157051494.1|DBSCAN-SWA
MCTVPMSSVSKNSYIYADNAATTQLSVVAYASMTSFLVDEYGNPSQPYAFSRPVKRALREARESIASCINADPGEIVFTSGGTESDNWAIKGFALRDDMMREIVTSEIEHHAVLDSCKAMSAIGHRVAVLPVSRTGVIALDALREMSLGDGSLVSCMYANNEIGTIQPIGELCDIAHSKGAIFHTDAVQAVGHVEIDVKAMGVDMLSASAHKFNGPKGIGFLYIKDGTPLAPYANGGAQEMGRRAGTENVASIVAMAVALKENCDAIEANAVRLGRLERLLLDDLAALGVPYRRNGENQLPGLMSLSFAGASGEMLLHRLDLMKIAVSTGSACDGANTRVSHVLKAIGLPEAEAKETVRISLGKHNGEGDVHAIATALGKILLRD
>NZ_CP012069|2222725:2279035|2276976_2277723_-|WP_050340993.1|DBSCAN-SWA
MGIAAYPHLIPVIAVKQGMDDVLSPEQVVSLANDLRRDNPSQRIALRFDDIDGYENVAKQVLRDGDCLIYDFNEQPIRSKPVECRRLKNLNLPAQTVALCSPRRRELTGKDFKNCKDGEVTNLIDNTHLDVYRNYGFDGVGDYGGLRDNLPDRGANKGRALAIMYDGKVNGFKIYVKDDYDLGPNGFWDVVEHMLADTELAQDDTCLALAAITDKYRRHEKGYTFAEWIKYTLVRYIQQLAMSRPGFV
>NZ_CP012069|2222725:2279035|2256437_2257832_-|WP_050340969.1|DBSCAN-SWA
MEDKVWKTALWNRSWDDLKAKKYNAEGFCQFSEDKGVHLEIPSGDLSLTRKLAETGHCEIGMESDRYEYLFGITQDGIYLLLIDAISNRVGLSFPGHTRESLEASTVLSSHDEFDPSIPISTADFEIEGLRKWLGLHSSPEIREDNLVIEGGRQNEVIDVYRSDRCAMTIHSGIGKIKSDHEGFRYSTYATVHVDYKNGVSLDDFWSCELWKFQSFLSFCFGAYTSIRQVRVKFKDNGSPVEVHRGSFLTRNTIRNYQCVPVPFQLIKSILFDVVTRWMEMKGDESQSSKMLVSLLGSWKIPVDLKFFAASSMFESLARSGCDECFDKKDLECLITPMLRVADESIRDRARGLLGLLRQPSYSMLLDHAYEESDRWGRGIVPDWKRFRKEQNKLRNASAHALENNSEYEQMVDHHDAQILIAYVIIMKRLKLPDEVLDQFEDSTFMNVSRWRVSEHYASNDSHS
>NZ_CP012069|2222725:2279035|2272289_2272604_+|WP_050340984.1|DBSCAN-SWA
MIISSSVEAGALIGSLREMRSLSRRELSAASGVPLRTVYAAENGELRNMSIDRVISLLSALGASLNVEVEATNADETRDDETNILVNKAARGAYDLADSWGIGL
>NZ_CP012069|2222725:2279035|2237414_2237957_+|WP_050340938.1|integrase|DBSCAN-SWA
MNGIDRGNPTGKRDYAMLLMVARLGLRASDIKSMLISDVGWSARTISITQHKTGVPLELPLLDDIGWAVIDYLREGRPKAATCPQLFVRQVAPFDAFGATANLTNILIRRARGAGIRAPRDHKTLHSLRHALAKRLPGQEVPIEDISRILGHVDRRTTSIYLRMDVDSLSACALDPAVIA
>NZ_CP012069|2222725:2279035|2232395_2232680_-|WP_157051489.1|DBSCAN-SWA
MNLPIATLPWSCLWRSPASGRPRGRVSRRAASPITVLSNSKGLPRALVSRQRPRPVLELPEAVTCGDYGNGEERKCRLGANYAARWRRMNEMLK
>NZ_CP012069|2222725:2279035|2236716_2237415_+|WP_050340936.1|DBSCAN-SWA
MADHTNLEALISDTLVEMRRLGYSENTITGLRRMFAALSRYAVSQGRKESGEELAIRFPDAKFGVELTQPCQANPGGSYLKAWLRAMRVLLEMGECGRVCKRMPGDLVRTELPEESRSLPGPSDDASRRAGHSESTIYSRNGRIKHFLIFLAGNGGTDASCITESSAHDYILTKSSNHAKSVRAILTALRCLPRHPRLGARRDATSRRACRIPSPAMPPSFPPPGRRTRCRG
>NZ_CP012069|2222725:2279035|2245566_2246295_+|WP_050340953.1|DBSCAN-SWA
MECAELKVSKLMKPWDVVIELGDGLPEGSWALVGGLMTQAHAMIAGCQSRATVDVDVLVDVMASTPNISTVIKQLESMGFALKEPGLRGTAFHRMTRGALVADILVADHLPSGKARSAKVNGWPMMEIAGGAQAIERGMDLALIHEDGSTRIRIPDLLGALVLKSAAYCADRRDRRRHLDDIALLASLVTDHKGCIERLHGSDKRRLRTAARALFDPNSSSWTRLNPEKRKAGQFTLAVLTR
>NZ_CP012069|2222725:2279035|2229232_2229568_+|WP_050340922.1|DBSCAN-SWA
MGKLLAHKEGSGTIEPSTMRGYRAEARQMDSCIGNVRLANLSVEDASSWMRDMGADGYAPQEPPQGVPPAQADAQVGRHPEPRLQESLRLPQAAQAREDADSLPAVTTAPA
>NZ_CP012069|2222725:2279035|2267228_2269466_-|WP_083444105.1|DBSCAN-SWA
MSNEPRPVYAAELNLLGMDKYWRFDQQNETPYMWSEACNYIYRGTKVAKIKGGALCQAPVLELVHTKADDGDATLALPQGTTLLAVDIPAMVERNKDALSIVEQITVKKIYDYYKRYKDKLDCFHVAFSGGKDSVVLLELVKRALPRSSFMVVFGDTGMEFSDTYRIIDQEEAICRKDGIEFHRARSHFDPMDSWRLFGPPSNVLRWCCSVHKSAPQTLKIREVLAKGDYVGADFVGVRAQESVRRADYEYENYGKKQRGQYSLNPLLEWSSAEIWLYIFANALPINDAYKKGNSRAGCLLCPMGGGKADYFRHAAYGKEIDRYTDTIRELIDDKSIDTYVTNGGWISRRNGRDIKGNVSNYIEEVKDGYLYMIIPKPKTSWTEWMKTLADPPTSLYVEQRKEGLVARISAELNKTSIAKQVKQIFHKVAYCGACRVCEANCPYGYISFEGGLHIDDRCVKCGKCRQIEDGCLLYHSLQLPKNGGRVMKSLNTFADHAPKYEWVRDFYERGDEFFQNNSLGPMQISMFKRFLSDAQLAEKNKVTEFMLLTKRIGWESDSAWGLILIQLVYENPQIRWYIDNMPVNERMPRTYLEDLLSETGMSEKDAKSITKAFGRLCDLPLGTALNFGAVEKKGRQITSLTRYKASLRDDRVILYALYRFAEACDGYYQFTLSRLLDESIVSNGICPSRLFGLDSDAVKQIVYGLSAGYPDYLYATFTHDSEKIQLRENKTSQDVLGLFVGQEQ
>NZ_CP012069|2222725:2279035|2263053_2267226_-|WP_050340978.1|DBSCAN-SWA
MDTYSDYFDIDENYYPEINPNSISDPNSRWDGTFPHETFVDLLRATERMLARETNTDKKGIWIEGAYGTGKSRVAWTLKSLLECSPEELNSYFDEYDNLKRQPDLRDKLLAHKGDHIVTVFCYGSGEVDSIRKLVMTVFEKVTKALHDLGYDYRGERTLRGKIASWISAHKKIFGMYMSMPQYVGLGSFAGNTADDIIAHLENLEQGADELISQILDMADREGIRTFDISMNDLTAWLKDVIEQNKLKAIVFIWDEFSSYFKNNRTTLDEFQKLAELSNEKPFYLMIVTHMSGSLVDEGNQAFKIVRDRFVRREIEMPDSVAFDLIGHALKVRPAAQDEWAGLSDDLNSRMTSSRGQVAAVVGTTDKALTKLFPIHPMAALLLKYISTTFASNQRSMFNFIKNPDTDDLQAFQWFINTHGPDNGDVLTIDFLWNFFYEKGTDENTFMSGRSNLDFIVATILDTYPNNEHKLNGEQKRVLKVILMMQAISQKLNNSVSILRPNDKNLNLAFEGDDSLENNRAVSVANNRLVKMGILYIKPTEEGDEYAAAAVSGDQVQIDAIRRKRLAETRTARLISDAQLESAITYKPSIRARYEVKLACVDDFRPTVNKIINERQTYRSRAVMCFARNENEQVRIREKIKEATADPNSKDIVFIDASESVLGADRFGRWASFAANEEYWRSKDGKLADNHKKSAEDVLADWRNDVSNGAFDVYVGQLKEHCASTMRVSGVLEDLVIKRYPLSFDRIEVSEAFFSSRNLSFGAKVGIQQAYGGIYQQDAISRLLLGVQNTPEYWNDPQLKSLPISKLKVQIDALIKERLDRDARISISEIYDFLEERGFMPCNLYAYLTGFLLKEYASGTFMYGSGASGDAGGRMTVERLAELIGAYMKHKVKPVRNYRDEYIEVMTQEQKRFVDFAHEAFGVSDSLSVEPTAARVRNELTNFGYPIWCLRSIDTNALDPFIEKLSEIVSKNASGNVPALTNDFGRMLEEVPTAASNLTKLFTRENGALAMREFLHSFEGGQILKVAEAIGVEDVLADVKRQIGSGDALWLWDQEDGENELRKLLVDYCIVERSNQLITKRNSFSSCMREWNETTKYIKIPYLVLIEKCPDLKQLISSIYEIAKNGEISHDKREAFLEQLVTKAGALKDVLDRQKDIFAEIYSTYTDGFGAADINKLYAKLPKSSFMGDKSAFEKSVQEHAEEIRTNQKKFQLHKLWKESTHSKDAHDWSKQHKTPLLALVPVEEREAARTFFAILHKENPIIKQVDGALKYLENKPVFLSLMSSDERVEIAFSHEVIGKYRSILTDNEEVRRYLESNAFENVYQWCDSKQVSDAVRSLAESKYRLGANQAAIDLIDGMDTTHAKTYLKRLVRENVEVGIEIIAKKEARQ
>NZ_CP012069|2222725:2279035|2259261_2259462_-|WP_050340973.1|DBSCAN-SWA
MKNVACKSCYKESLTKDEVGISKKLLGEGDDDVLCLDCLAAYLDCSVDDLLDKIEEFKDEGCALFQ
>NZ_CP012069|2222725:2279035|2276164_2276980_+|WP_050340991.1|DBSCAN-SWA
MGGKMAYIEGLADAGQRLYDAYSTVMTEANLSGVLDAILGANRFDYPQTTARDLINRIVLGSYPNEATIKANFINGILLPQSPKTVSVFELPIGKSRVDMCKINGHSAAYEIKTDLDTFYRLEGQLKDYFDVFETVYVVTSEARWRELPDYVPEACGIYSYRQCEDGTYKFCARRRAIKSSELDSEKQLSVMPKQFLCSLFGKEGRRVSKTSLIRSCLEEHDGREINHLFKRYLQQRYGCYWNRFRELQPEIYEIDYQWFYRYGLSPQAIY
>NZ_CP012069|2222725:2279035|2233699_2234710_-|WP_157051491.1|DBSCAN-SWA
MPGMILQEARRLGVDERRRLIGLLRAQVLAELGEAGGEPDACPRCGGTHLVRKGHDRDGSQRWARGSCGRTLSRKTMGLLGYPELREDVWASYVEHACAGGTPGECARACGVCPGTSWFMRMRLCEVMGRALAPSGSGPTVSCQVDGTYLDESPAGRRPGSAAGMPREPHRCGGAVRERGISNLKVCVVCGGRPRRRVLRGRGPGPADRRGVRPRPWGPWARERPSRPTASVGTPGCSPGSACRATTRRPRGRPCAASSAWRTRCTRGPRASWRASGGLDEEARPLPRLVPVGRADEEVGRRQGGHPVGPGGDGELRQHAVRPREGAAAVLVLLGG
>NZ_CP012069|2222725:2279035|2237953_2238901_+|WP_050340939.1|integrase|DBSCAN-SWA
MTFAKITSAYVAERRAVGLKCERDDRVMARIAALHGELGCPEDELPRALVEAWIAKRPGESETTGLRRIGQVRGLANYMMRAGYDAYVAPGRRGRADRGTYEPHIFTDAELASLFSTAEAIAGGDPASRRAQAARLLRLLYSSGLRCGEACSLAKGDVDLEAGIPAIRHAKNGKGRLVPLHPSMTHMLRIFHDTAALRHPQYGGHGLFWSLPEGRPMTTGFVYRFFRKALWAAGISHGGRGRGPRVRDLRLAFACHRLRNWVREGADADAMMPVLAAHVGHADIRRAEYYLRPAAEICPGMVAQVERECGWVVPS
>NZ_CP012069|2222725:2279035|2230296_2231079_-|WP_050340923.1|transposase|DBSCAN-SWA
MVQTRLDMGALRPIDDLMFRVMAQSKDFCEEVLRVLLEDPGLTVVECTPQSAVTNPHGRSAVLDALCELSGGGFVDVEVQRVDEGDLQRRARYYASLVTADRTGPGDRFEDVPDVCVAIVCEFDPFGAARSLYHMDRVLRETGEAGDNGLAEVYVNALARDGSEVAALMRLFVEGDAYDDARFPETSSEKRRLRETEVGRMAMGSVIEEIRAEGEAKGEAKGKLETICGFVRDGLVSVQDAAASAGVDASEIERALAAQG
>NZ_CP012069|2222725:2279035|2228921_2229194_-|WP_050340921.1|DBSCAN-SWA
MFTEPEEKTPPSETPTLGIPRTGDANVPAAVLGALAVLAVGAIVGAWCNLSARMQRPRSSAVAPEGAMRSEGRALRGGDRLQALPILVYA
>NZ_CP012069|2222725:2279035|2222725_2224663_-|WP_050340911.1|integrase|DBSCAN-SWA
MSAGGERMRGRWADALRAFIAERRACGYAYGRSHVCACERLCSFLGERDMDEAAFAEWAAPRDGEACRTRANRVGLWNVFAGFCARRDIEAGSFRADVRLESDFVPHIYTDEEASAVFSAADAGIAQRRSPYEPSLIMPAFVRLLYSTGLRFSEAAGLRWDDVDGRRLSVLGKGGKPRLVVMSASMAEVLERYRGLRVGGGGGLVFCGRAARCRTSSSAHGTGPSWIPQACAGRTGPIRACMTGGTRSRSGRSRGWTPRGSTCARPCRSCPGTWATAGPRRRNGTSASRTRDARASSSAWSCTRRTWPPAWEGCEMDGFEGHVARFFACHLPDVKGASPNTVASYRDAIVQFVSFASGRSGKVVEALGVEDLGGDALGEFLDHLERSRGVAVSTRNHRLAAVHSLFRYIQARDPVWMEACSSALAVGRKRCPPPLVGYIGVEGMRAVLAAPDPSTREGLAHLAALSLLYESAARAQELIDIRACDLSAGFSAVVLRGKGGKSRVVPIGREVSAIIDRHVRESGASGDAPLIAGRQGKLSRSGLRYVVEKYSEAARSDGANVPPKVTPHMFRHSRAMHLLEAGVNLVYIRDLLGHVSVTTTEIYARANPEMRRKAIEERGARIAPDAAYDESERQDLLSWLKSMDW
>NZ_CP012069|2222725:2279035|2272600_2273908_+|WP_083443945.1|DBSCAN-SWA
MSSGIRKMALYIAGRLAGHVRQDENGALSFSYAPDYLGAPVSLFMPLSPMTYRQHVVRPYLMGLLPDDPTVRADIADRYGCSGENPFALLSHIGLDCPGAVQIVPESERALIDNRVGHLIELSAKEMEDTIRVMRLRSSSPWQTSNGQSERWSLGGAQSKIALRLTRGTWYRCEGDAATTHILKPGVSGYKNQALDEHLCLRLAASIGLPAAHTSFVSFGAESAVVIERYDRVTGDDGSVTRIHQEDLCQALCVDPSRKYAEQGGPSTPDVLALLAKTGRHAPANLRTFTLFLIFNYLVGATNAHAKNYSLLLGTRGLARLAPLYDVASIAPYQTPAPRRRKPLRAAMSIGGENRFGRLGQGHLRKLAADPALANSGVGYDWLMASAKRMAEMVPGALREVVHESAKDGLAGIEVVGPLLEREVSANCRRLLERL
>NZ_CP012069|2222725:2279035|2240044_2240233_+|WP_050340943.1|DBSCAN-SWA
MVKQACRMRRSARYIRLPDLLMERDELAVTEHSDAKMLRKYARYGLPVIDEWLTEDVDDVAI
>NZ_CP012069|2222725:2279035|2228268_2228931_+|WP_083443938.1|DBSCAN-SWA
MDSKLTHISKEISYALRHAPWEYELELDEQGFVPIEQLLQAMNEGRDEGDAVALADLERIVAESDKQRHEIDGDRIRALYGHSVPKRIERLAAEPPAVLYHGTSHEAAQRILAEGLRPMGRQYVHLSCDVETAEAVGRRRDRSPIILSIDTKRADGDGVAFYRGNDKVWLADSIPADCISVRKGSPYGRPSRQLTAEPADQRPRIPSSGHTARPEATHQA
>NZ_CP012069|2222725:2279035|2254185_2254938_+|WP_050340966.1|DBSCAN-SWA
MLTEEHFELFKEFRVKAMGDKLREMVEDDSYDAYTFEERMEMLIDAEASARRERKVAKLVKQARFKTPSACVEDIVYLPDRKLSRDRIARYAECDWVEKCEVMVIISKTGGGKSYLCQALGNAACRKLIEVRYTRLAGICEELNRARAAADGSYYELMDGLKTIPLLLVDDFMTTPITTQNAVDLFEIMEARESLAATLIASQLEPNEWYLRIEGELMADSILNRIATGARYIDLEGPNMREYFAKKKVG
>NZ_CP012069|2222725:2279035|2241461_2242433_-|WP_050340945.1|transposase|DBSCAN-SWA
MPKKNACAARVAAMTDDEFTELAAAVDERRCRDEYGFGTYAEAAALYRPDPACPSCGAAEPSRDGWSESGLQRYRCESCGTRFNSLTGTVLEHCRKELATWVGFVNLMRFNVPLDAAAETCRVTHQTAWEWRHRIFAAVDGCQERIVLKDRVWIDETYVNDTDLAHGYGEARKRGLSKQKLCIAVAIDVHKNPVAVVCGHGKPSAKRIRDGLQSHIAEGSTIVGDKEKSHDSLVRAVKGTHEAYRADVGDPVYLERMSLVNNLCSWLKRYLWRFTGMDPKNLQSYLNWYVYLFRVNQARDRWPETERVVRHLLMTDARFHSST
>NZ_CP012069|2222725:2279035|2277961_2279035_-|WP_050340811.1|transposase|DBSCAN-SWA
MAQLTFSDVEMGMGRKRETRRSRFLDRLSKSCPWDAWLALVREARGADAGARGAGPAMGRPRVDDLVLLRMYMVQVCFGLSDRECEDQVWDSATMRSFVGVAPFEVPDATTLCKFRHLLERCGVGEAMVSSAFGSAADGGLAVSRGTIVDATFIESPSSTRNADGARDPDAHQAKKGQNWHFGYKLGVGVDAETGVPHSVRMDAANVHDLDQVPDLVREGDERVWADAGYVGVGRRPEVAGDPSLSGVEWIVAKRRSQVGEDDLVAEAAKSAARSVVEHVFHWVKDIFGLRKTRYKGLAKVSNQAFAAVAAAGCMIARRGRRLCGPPLALSAERIALQRERLEERRRRAEGGAPAAA
>NZ_CP012069|2222725:2279035|2246425_2247736_-|WP_050340955.1|DBSCAN-SWA
MHGIPKAEKVLDDFWNAALSEDKLSARFMKDADATVETVEGKDIVVIRVPWVDRCTRPVYIDNSIFGGTFRRTHTGDHQCKREEVLSMLRDSDTSSQDAAIAESARVEFINRETVAAYRRRFDQRNEGHVWGKADDETFLTDIGALRVNENGELRPTRAGLLMFGEDRWITYEFPHFFLDYRQETGHDTRWEDRFTSQPGDWTGNVYDFYFRVYNKLKAALKVPFRLDGVDRVDDTPAHEALREAIVNALTNANWFDRRGVVCVWDDEAITIANPGDFRMPVEEAKKPGSTDPRNETMMRMFAMVEIGERAGSGMDKIFGGWAWAGYAEPGYEVAYGPDRTTLTLPLVSADSAGEAPSKTVEDRRRPSKRGDDSLTDAQRAVLNYLEANGPSRTAEIAQGIKMGTSQTNVLLRGLTELEFVSVSGATSARRYRLHD
>NZ_CP012069|2222725:2279035|2269534_2271682_-|WP_050340982.1|DBSCAN-SWA
MAVRTRFDKQEAALLLYAYLQVENGRLTRSQAVEYVSKALRRRAELHGIQTDNSFRNTTGISYQYSVMEYVMTDGESGIPHPPILFQKVVRLYRSDPARFCSAIAAALRGRSSTRRPTVSPVTDAKHEVFPTRSNEVDSAENRVYSIDANGFKRWMMSKGLTEHAAVSNSSAIDAVERFARSHGYQGRIFYGNANIHEIKTNAQMLLKDTNSTYSNERYSRLSGALERFILFIEAMGNPSRLGGYGHDRARQATRTIDPGLERRILDTLSKGYPNGIRLDSTIDIKRFAHMYHENFDEEAPSKKAISDVILKNGGIEWSGKTYLIAEEPKQAVRQLLEDSIKAGQRIFYYQELYEANPDYYSDMKVNSAEILEKIIRSTGIKLLYNEHYCVTTGGVSIEDEILRAFADDEQLSADELKGRLPYLPYKKIKSTLSASKLFVLIKRNEYAMVSRINLDPLELKEAPNFVAGEITSQGFASLGTIDITRSLGGNPQLSEMAIRNALYQQVLARTFDRKGQIILPKGGNLSRNEVMRARCLTLDAMTVDEMDEFEAELLGKARNAMLPVAFETMVRVDRDTFVKDSTIDFDVEAIDDALALFVSGGVAPIKVITSFTSFPYVGRPWNLYLLESYVKRFSRRYCIKGGSPARTANVGVICLANDDRDYNDVVAQVLANSSLKLEEHAVGDYLVRLGFVVKKTIFVKKVTEQARVLRDAAG

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_050340911.1|2222725_2224663_-|integrase	tyrosine-type recombinase/integrase	A0A0K2CP59	Brevibacillus_phage	1.2e-15	25.4
WP_157051485.1|2224646_2225891_-|integrase	tyrosine-type recombinase/integrase	A0A023W6X0	Mycobacterium_phage	1.2e-05	34.2
WP_172674477.1|2225937_2226648_-	Abi family protein	NA	NA	NA	NA
WP_062393132.1|2226812_2227277_-|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_050340919.1|2227904_2228279_+	hypothetical protein	NA	NA	NA	NA
WP_083443938.1|2228268_2228931_+	RNA 2'-phosphotransferase	NA	NA	NA	NA
WP_050340921.1|2228921_2229194_-	hypothetical protein	NA	NA	NA	NA
WP_050340922.1|2229232_2229568_+	hypothetical protein	NA	NA	NA	NA
WP_050340923.1|2230296_2231079_-|transposase	PD-(D/E)XK nuclease family transposase	NA	NA	NA	NA
WP_157051489.1|2232395_2232680_-	hypothetical protein	NA	NA	NA	NA
WP_050340926.1|2233195_2233393_+	hypothetical protein	NA	NA	NA	NA
WP_157051491.1|2233699_2234710_-	hypothetical protein	NA	NA	NA	NA
WP_050340930.1|2234799_2235795_+	RES domain-containing protein	NA	NA	NA	NA
WP_157051492.1|2236233_2236521_+	hypothetical protein	NA	NA	NA	NA
2236572:2236631	attL	NA	NA	NA	NA
WP_050340936.1|2236716_2237415_+	hypothetical protein	NA	NA	NA	NA
2236572:2236631	attL	NA	NA	NA	NA
WP_050340936.1|2236716_2237415_+	hypothetical protein	NA	NA	NA	NA
WP_050340938.1|2237414_2237957_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_050340939.1|2237953_2238901_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_050340941.1|2238917_2239904_+|integrase	tyrosine-type recombinase/integrase	A0A218M9P0	Mycobacterium_phage	2.3e-07	28.6
WP_050340943.1|2240044_2240233_+	hypothetical protein	NA	NA	NA	NA
2239940:2240029	attR	NA	NA	NA	NA
WP_050340943.1|2240044_2240233_+	hypothetical protein	NA	NA	NA	NA
2239940:2240029	attR	NA	NA	NA	NA
WP_172674478.1|2240608_2241442_+	ATP-binding protein	NA	NA	NA	NA
WP_050340945.1|2241461_2242433_-|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_050340947.1|2242769_2244317_+	hypothetical protein	NA	NA	NA	NA
WP_050340949.1|2244392_2244857_+|transposase	transposase	NA	NA	NA	NA
WP_050340951.1|2244878_2245580_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_050340953.1|2245566_2246295_+	hypothetical protein	NA	NA	NA	NA
WP_050340955.1|2246425_2247736_-	hypothetical protein	NA	NA	NA	NA
WP_050340957.1|2248117_2248309_-	hypothetical protein	NA	NA	NA	NA
WP_157051493.1|2248573_2249467_+	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	NA	NA	NA	NA
WP_050340962.1|2250494_2252276_-|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_172674479.1|2252593_2254192_+|transposase	IS21 family transposase	NA	NA	NA	NA
WP_050340966.1|2254185_2254938_+	ATP-binding protein	NA	NA	NA	NA
WP_050340969.1|2256437_2257832_-	hypothetical protein	NA	NA	NA	NA
WP_157051494.1|2258122_2259280_-	aminotransferase class V-fold PLP-dependent enzyme	NA	NA	NA	NA
WP_050340973.1|2259261_2259462_-	hypothetical protein	NA	NA	NA	NA
WP_050344523.1|2259442_2260909_-|protease	BREX system Lon protease-like protein BrxL	NA	NA	NA	NA
WP_172674480.1|2260918_2263042_-	BREX-4 system phosphatase PglZ	NA	NA	NA	NA
WP_050340978.1|2263053_2267226_-	hypothetical protein	NA	NA	NA	NA
WP_083444105.1|2267228_2269466_-	phosphoadenosine phosphosulfate reductase family protein	NA	NA	NA	NA
WP_050340982.1|2269534_2271682_-	hypothetical protein	NA	NA	NA	NA
WP_050340984.1|2272289_2272604_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_083443945.1|2272600_2273908_+	type II toxin-antitoxin system HipA family toxin	NA	NA	NA	NA
WP_083443946.1|2274155_2274749_+	AAA family ATPase	NA	NA	NA	NA
WP_157051495.1|2274750_2275227_-	hypothetical protein	NA	NA	NA	NA
WP_050340991.1|2276164_2276980_+	sce7726 family protein	NA	NA	NA	NA
WP_050340993.1|2276976_2277723_-	hypothetical protein	NA	NA	NA	NA
WP_050340811.1|2277961_2279035_-|transposase	IS5 family transposase	E5E3P6	Burkholderia_phage	5.2e-53	39.9

Sequences of DBSCAN-SWA_6

Nucleotide sequences of DBSCAN-SWA_6

>NZ_CP012069|2340091:2353324|DBSCAN-SWA
GTCACTGCGTCGCCCATGTGGTGCCACCCGCCCTCCTGGACCGCCCGATCAGGGTGTTGAGCCTGTCGGCGATCCGCTCCACGTCGGCCTCCTCGCGCACGACGAGGCTGCTCACGTTGACGGTGACGCCGTCCTGGCCGCCCCCGACGCCAAGCTGCCCGAGGGCCTCGACGATGAAGCCGACGAGCCTGTCGACCGGGACCACGGCCTCGGGCCCCGCCTCGCCGCCGCCCATGGCCCTGCCTCCGGCGACGCCGAACAGCGTCGGCCTCGTGAGGAGCGCGCCCCTGGCGTACCAGTCGATGCCGATCGACGGCACGGAGAAGTGGGCCGGGTCGAGGTTAAGCTCGCCCGAGACCGAGAAGTGCGGGAGCGGTATGTGCGGCCACTCTATGTGGAGGCCCCTGAAGAGGCCCGCCACGGCGTCGAGGCCCCCGGCCACGGCGTCGCGAAGGCCGTCCATCCTGCCCCCCACCAGGGACGAGAGGGCGGAGAGGGCCCCCTCGGCGATGCCGGGGACGCCGCCCAGGATGGCCCCGAAGTGGCCGACGATGCCGTTCAGGACCCCCACGACGGCCCCGGACAGGCCGTTCAGGATCCCGAGGACGGCCTCCTGCATGCCGCCCATCGCGGTCCTCGCGCCCTCCGCCGCCATCGACCAGTCGCCGGTGAAGACGCCGACCAGGACGCCGAGGACGGTCTCTATGACCCCCACGGCGGCGGTCACGGCGCCTGCGACCACCTGCATCGCGCCGGACACGAGCGCGCCCGCCACCTGGAAGGCGGCCCCGAGGGCGTTGAGCGCGAGCGACGCGACCAGCTGCAGGGCCGGTCCGAGCACGCCCGCCAGGGCCTGGGCCACCGACGCGACGAGCCCCGCCAGCGTCTGGAGGGAGGGGCCGAGCGTCGCCTGCGCGCTCGCCGCGACCTCGCCGAGGGTCTGGGAGACCACGGAGAGGGCGCCTCGGGCCGACTCGACGACCGGGCCGAGGGTGGACTGGACCCACTCGGCGACGGGCCTGAGCCCGTCGAGGGCAGACCCGCCGCCCTCGGCCATCCCCGACAGGCCGCGCGCCAGCTCGGATATGACGCCCGCCGCCGCCCCGATCGCGGCGGCGAGCCCCTGCCCCAGGGCCTGCACGAGCGGCTGGAGGGCGTCCAGTGCCGCCTTGGCGGCGGGGCCCACGACGTCGATGACGGCCCTCCCCAGCTCGCCGAGCGAGTCGAGGAGCGACCCGAAGGCCTCCTGCAGGGGCGGGCACACGGCCGTGAGGCCCACGAGCGCCGCCGCCGCTATGCCGACCGGCCCCCCCAGCGCGGAGAGCAGCGACGTCACGGGACCGAGCAGCGGCCCCACCATGGGCAGGCCGGCGAGCACGGGCGCGAGGCCCGAGGCCGCGAAGGCGGCGAGTCCCGCCACCACGGGCGCCAGAGCCGGCATCACGGGGCCCAGCGCGGAGGAGACGCCGTCTATGGCCGGGCCCAGCTGCTTCATGAGCCCGACCACGCCCTGTATCACGGGCGTGGCGAGCGGCTCCGTCATGCGGGAGAGCGCGCTGCCGACGTTCGCGACGGCGCCCTCCAGCGTGTCGCCCGAGGACTTGGCGGCGTCGCCGAGCCCCTCCCTCATGGCGTCGGAGAAGGTCTTGAAGTCGATCTGGCCAGAGGAGACCATGTCGGAGACCTCGGCGGTCGTCTTGTGCAGGTGGTCGGCCAGGAGCTGCAGCACCGGCACGCCGGAGCTCGTGAGCTGCAGCATGTCGTCGCCCATGAGCTTGCCCCGGGCCGCGACCGACGAGAAGATGACGCCGACGTCGTTGAAGCCCCGCCCGGAGGCCGCCGCCGCGTTCGCCACGGCCTGGAGGCTGTTGGTCATGTCCTCGCCGCTCCTGATGCCGGCCGCCGAGAGCGTGGCGGCGGCCGTCGCCGCGTCGCCCAGGCCGTAGGCCGTGCCCCTGACCGCCGTGGTGGCGGAGTCCATGATGCTCTGGATGTCCGCCGCGTCGTGGCCGAAGCCCGCGAGCTTCTTCTTGGCGTTGTCGATGGCCAGTGCGCGGTCGAACCCGCCCTTGACCGCTATGCCCGCGACCGCCGTCGCCCCGGCCTGGCCTATGGACCCGAGCGCGCCGACGAGCTGCGTGGCGTTCTCCCTGACCGCCCCGAGGGCGGCCCCGGCGCCCGAGCCCATGCGCCCGAGCGCGGAGGACGCCCTGTCCCTTGCGCGCTCCCACGCCGAGCCGGTCGCGTCGGCCGCCCGCCCCACCTCCGAGGAGGCGGCAGACGACGTCTCGGAGCACTTGGCCCTGAGCGCGTCGAGGGACGACTGGGCCCCCTGCACGCCCGCCTCGAAGCCGGAGCTGTCCGCCGTGATCTTGGCGGAGAGGGTGTAGTCCGACATCTCCCTCCCCTCAGCCCATATGGGCCGCTATGTCCCTCATCTTTCCGACGGCCTCGCCGTGCCCCATGGCCTGCCCCCGCGAGGCGTCCTCGTAGAGCGGCAGCGGGTCGCCCCCCTTCCTGCGAAGGGCGTTCGCCAGCGCGTTCGCCACTGCGTCGCGCACGGCCTCCGTCGCCCTGACGTCCCTGTCCTCGACGGCCCTGGCGAGCAGGACCCTCTGGGCGTCGGTGAGAGACCCCCACTGCTCGGGGGTCCACCCAAGGCGCGCGGCCACCACGGCCCACTCGGCGTCACCGGCGTGGGCGCCCGGGACGTCGGCGGCCCAGTCGTGCCTGGCCGATGAGACCCCGAGGCGCCTCAGGCGGGGGCGCCGGAGGCCTACCGGAATAAAAAACCGCAGTCCCTGAGGATCGCGGAGGAGACCATCTCCATGGCCGAGGACAGGCCGCGCTCGGCCACGTAGTCGCCCGCGATCCCCATGGCCCTGCCTGGGGCCGCCCACGCGGACGTCCCGGCCTCCCTCATCCCGTAGGCCATGAGGGAGCGCGCCTCCGCAAGGGTCGGCGTCCGGCTCAGGACCTCGATGACGCTCCTCTTGAGCGCCGCCTCCAGCATGTCGATGCGCCTTGCCGCGTACGCGAGCTCCCAGGTCGTCCCGTCCCACTCGAACGTCGTCGTCTCCATGTCCCCTCCCGTCACCTTCCGCGATTCGAGGGCTTGGCGGTCGCCTTGCCCTTCGCCTCGGCGTCGAGGTCGAACCACGTCCACTTGCCAGCGCCCGTGAGGGTGACGGAGATCGATATCACGTCGTCGGACGGGCTGTCGTCCTCGTACTTCGTGACGAACGCAAGGCCGCCGCCCCGTGGCGGGTAGTCCCTCTCGTCGTCGTAGACCTGCTTGACGCAGAGAACACTCCCGTTATCGAACGCCTGGCGGATCAGCCTGTTCGACTCCGCGTCCATGACGTGGACGGTCTCCAGGGACAGCTCCCAGCTCCTCGTGGAAGGGCGGCTCGTCTGCCAGCTGCCCCGCCTGTCCTTGGTGGAGTAGCTCACCGTCTCGGCGGAGAGCGACAGCTTCGAGTCCTTCTCGCCGTCTATCGCGAGGAGCTTGTCTCCGACGCTATTGAAGATGCAGGTGAGGACGTAGGCCCCGTCGGTGGCCGACGCGCCCCCGTCGAACTTGCAGTACGCTCCCGAGTCGTTGTTCTTGCTGTAGTCTGGTTCGGGCATCGGCGCCCCTCCTAACTGCGGCCATGGCCGCTACTTGACCATGAGCCCGTAGCTCACGGTGACCTCGTACGCCACGATCGCGTGCCACTCGCCGGTCGGGTCGCGCTTCACGCTCTGGAGCCCCATGTCGTCCTGCCGGACGAGGCAGAACGGGCGCGGCAGCTCCACGTCCGCCTCCATGGCCTCCTGCAGCGCCCACACCATTGAGAGCGCCGCCTCGCTCGTCCTGGACGGGGCGGAGATCGCGTGCACCTGGAGCTCGTACACGTCGATCCTCAGGCTCTTGGACCTCTCCGGGCGCATCCCCGTGAGCGAGACCGAGTAGAGCGGGCTCCTCTCGTCGCCGGGGTCGAGGACGCACCTCACCCCCGTGCCACCCGACACCCTCGCGACCACGGCGGCCACGAGGTCCACCGGCGACAGCCTCCTGAGCGCGCGCCTGCTCATAGCCCCTGCCTCCTCATGTGCTCGTCGAACCTGCGTCTCATCACCGACCTCGCGGCCGCCACCTCCTCAGAGAGGAAGTGCTGCCCCTCCACGTACGGGGCCCTGAGCGCCTTGCCGAGCCTTGGCACGTACTGGCCGACGTTCTGGCGGTGGCCGTACTCGACGTGGGGGGCGTAGTCGGCCACGTAGCCGACGTAGCCGGTGCTCGCGTCCTCCACTCGCTGCCTCAGCGAGTTCAGGAGGCTCCCCGTCTCCCTCGGCGTGATCGCCTTGAGGTCCTCGGCCATCTGGCTCACCGTGGCCCTCACCACGGACTCGCACGTCACCCGCCGGAGCTCGTCGAGCCTCTCTCCGAGGCCCCCGTCGTCCAGCGTCACCGACACCGCGCTCACACCATCTCCCCCTTCTGCCTCGCGCAGTGGACCGCCCTGCGCCTGCCGACGTCTGAGACCTGCACGACCTCGTATGCCCTCGCGTCTCCCCCCGTCGCAGGGAAGCGGACGAGCGCGGCCCTGCGCACGGTCGCCAGGGCCGCCGTCGTCACGAGCGTGAGGTCGCAGGCAAGGTAGCCGTTGCCCTCCTCGGCGGCGGCCGTCTGGGTCCACGGGGCCGCCCTCGCGCGCACCCTGCCGAGGCTGCGCCGCTCGGTCACGCGGTTGCCCAGGCGGTCCCTCCTGCCGGTGTCGGCCAGCTCGAAGAGCTCGGCCATGCGCCACCTCACAGGAACCTCACCGAGGGGAGCAGCGACGTGCCGTCCGCGCGGGCCATGTCGGCGAGCGCGGAGAGCTCCCGGTCGTACTCGGCCAGGAGGTCGTCGGAGAACGCGACCGACATGGACGCGCCTGTGCCCTGGCCCTCGGTCTCCGAGGAGATCCCCTCGTCGAACCGGCGGTTCACGGCCTTCACCGTCGCGTCCACCACGATCGACTCGGCTGGCGCCGGGAGGGACGCGACGCCCATGCGGGCGCACGCGCGGTCCGAGAGCGACCGTATGGCCTCGGAGAGCCACCCGTCGCTCGGCACGTCCTCCCACGCGTCCAGCCTGGCCCTCACGCGCTCCAGGATCGCCATGGAGCCACCCCCTAGCTGATCGTCCCCTTGAGGACGGCGTCGGAGATCTCGGGGAAGACCTTCATGCCGCCCATGAGGAGCGTGTCGATGGTCGCGTTGGTGGTCACGACGGAGTGCGTCATGCCCACGAGGCCGGTCGCGTCGGACGTGAGCCCAAAGGTCTGCGAGAGGCCGCTGCCGTTCGCGGGCGTGTAGGCCACGACGACGTTCCTGGCGGCGGTGCCGAAGACGCTGCCCGCCGTCACCTTGGCGCTCGTGAAGGTCGTTCCGAGGCCGAGGAAGTCCTTGAGGTAGCCCATCCCGAAGGCGCTCTGGGTGGTCACGGTCGCGGTCCCGAGGTACTTGGCCACGTCGGTGGGGTTCACGAAGAAGACGAACGGGCTGACCGCCCCGTCGTCGATGTCCCCGAACCCGTCGTAGTCCTCGAAGATGGTGTTGAGCGCGCCCCACATGCTTGCGAGCGCGGCCTGGAGGCCGGCCCCGGCGGGCGCGGTCTTGGTCGTCCCGGTGATCGCGGAGAGCAGGTCGGCCTTGACCAGGCCCTGCACGCCCGACACGAACTTCGCGTCGGTGCCGTTGATCGCGCGGTCGCGCCCCTTGGACTGGATCGCCTCGGCGGAGGTGTTACGGCGCCACTTCCTGAGGTTGATGGCGTGTGTCTGGTCGAGCGTGCGGCTGACCTTGGAGAGCGGGATGTACTCACCCTCGGCGACGTTGCCGTCCTTGATGTCCGTGGTGTACTTGTAGGTCTTCACGGTCCCGCCGTCCGCGACCGGCATCAGGTCCGAGAGGCCGAGCAGCCTCTGCAGGCGGCGGACGCCGGTGGTGAAGCGGTTCACGTAGTCGATCGAGATCTCCGGCGCGAGGTCAGTGGACTTCGTGCCTCCGGCCTCCGGGTAGGATACGGGCGTGTTGGGCATGCTTGCCCCCTTCTGTGTGTCATTGTCTGCTGGTGAAAAAGAGCTCCGGGTGCTCCCTGATGGCCCTCTGGCGGGCCTCGGTGTCCTCGATCTTGAGGATGTCGACCCTGGTGGGGGACTTGGCGGCCCCGCCCGACCTGGGGGCGGTGCCCGAGAGGCGCGCCCTGACGGCGGCGTCCACGGCCCCCTCGAAGGCGTCTGCGAAGGCATCCACGGCCCTCTTGGTGTCCTCGGCCGTCTCGCCCACGAGCGTGCCCACGAGCTCGTCGGGCACGCTGATGCCGCGATCGGAGAGCTGCCTGCGCGACTCGGCGACCATGCCGGAGACCGACTTCTCGCGCTCCAGCTCGTCGAGGCGCCTCTGCAGCTGGTCGCGCTCGTACTCGGCCCTCTGCGTCGCGTTCATCTCCGCGAGCTTGGCCGCCTCGGCGACCTTGGCCTCATGCTGCTCCCGCCACTTGGCGAACTTCTTCGAGATGATCGCGTCCACGTCGGCGTCGGTGTACCTCGCCTGCTGCTGGGTCGCGCCCTGCTGGTTCGCGCCCTGCTGAGCTCCCGCCTGGTCCTGCTGCTGGGCGCCGTCGCCACTTGCCTGGACCTGCTGGCCCTCCTGTCCTGCCATCAGTCACACTCCCTGTCCCCGCATGTCACGGCCCTGCGGCTCGGCCTTCGTCACGGTGCCTTTATCGTCGTCACGTCTCGGACGCGCGGGTGGGCCTCCCTCCCGGGCGACCCCTACCCGCAAAGCCCCACGATGCGCTCGATCGCCTCCTCCGTGGGGTGGCCACGGCAGCGCAGGAGCTCCTCGTCGCCGTCATCCACCGTAAACGTGGGCAGGTAGTCCACGTGCCGGTCCCTGGCCGCGCACGGGCGCAGGTCCACGTCGGCGAGGGCGGGCTCGACGCCCTCCTCGCGCAGGCGCGGCACGACGCGCTCGATCGTCCCTTTGCAGGGCGCGCACCACGTGGCGTGCCAGATGGTGACGGTGGGCATGGCTACCACTCCTCTCCGGGGATCCCGGGCTCTCCGCGCTCGCCGACTTCGCGGCCGGCGACCCTGGCGCACGACGAGCAGGCGGGGCAGCGGACGACCCTTCTCATGCATCCTCCCCGCACAATCGGGTACACTGTCATCGACGTCGAGCGCCGCCCAGGTATTCGAGCCAGGGAAGAGCATCGGCGTCATTGCCGTCTGAAGACCCTCTCAAACACGTCGGAGAGGGCGATGATGGCGTCTATGTCCTTCTTCGAAGCCATCGCCCGCAGCACCTCTTCCTCCTGCTCGCCGGTAAGCGTCCTCAGCGAGAGGTCAACGATGATGTTCGAGCACTGCCGTGCGGCCTCGCCGATTCTCACCTTCGCCTTGTGCGCGTTGTGGGTCCCCAGGCGCTTTAACTCATACGGTGCTCCGTCCACTGTCATGTCGGCAGTTCTTGATCCAGGGATACTCGACTCATAGTTGAACCTGACCTCATGGCCGTTCCTGGCGAGCCACGTGGCCGCCTGGATCTCCTTTGCCTTCGGCTTGGCGCGATACTCGGCGCTCACGCGGCCGTCGGATATCGACGCGAGGTAGGCGTTCACGGTCTCGTCGTATCCCTCGCGGCTCTTGCCGGAGGCCCTGTAGTCCCTCCAGACGCGCCCGAAGTCACTCTCGATGCGGCTGCATTCGTCCTGGACGGCGCGCGCCCCCTTCGCACGCTCGCCGCCTTCCGTCATGCGCCTGGCCGCGACCTCCGCTTGCCTGCGGTCCACCTGGTCACGTATCCACGCGTCCCAGTCGTCCACGGCGGGCGCTATCTGGCAGCGGCACCTCGGGTGTATCGGCGGCAGCGTCGCGCCCACCCTCGCGCCGTCGATCGGGAAGGCCTTGCCGACGAGCGCCGAGCAGACCTCGCAGGTCCTCTCGTCGCCCACGGGCTCCACGCGGTACTCCTCGAAGCCCTCGCGCGCGAGCTCGGCGAGCTGGGCCTGCCTGGAGACGTAGGTGCCCTCGGTCACGACCAGGCGCATGACGTCGCGCTCCGAGACGCCCACGAACCTCCTCGACAGCTCGTCGCACAGGCTCCGCCAGGACTCGCCGCGCGCGAGCGCCTTGGCCATGTCGTCCTGGACCCAGGCGGCGACCCTCTCGGAGTCTCCCCATATGGCCTCGCTGTAGCTCTTCCCCGAGGCCCACCTGGTGCCGACGAAGCGGCGGATCGTGTCGTCGTCGAGCGCGTGGAAGCCCCTGCCGTACCCCATCGCCTCCGCGACGGCGTTGGCGCCGCGCGCCGCCTGGCGGGCGAAGTGCTCGTCGAGCCCCTCGGCGGCCTCTGCCGTCGCCCTCGCGTGGTGCTGCCTGGCCGACTCCTGCAGGCCCTCCAGGCGGTCGAGCTTGTAGGCGTCCTTGCGGATGGCGACCATGTCGGCGAGGTCCGGGTGCTCCGCCGCGAACCTGTCGCAGTCGCGCATGAGCAGGTCTCGGTCGCTCGGGTCCATCGACTCGAGCATGTCGCGGTAGCGCAGGATACCGTCCTCGCCATACCTCTCGTAGTACCCCGCTATCTCGCGGGAGAGGTCCGCCATCTCCCTCTCGTAGGCCCTCGCGACCCTCTTGGCCACGACCCTCTCGTCGCGACCCATCGCGGCGTCGGCCTCGGCCATGCGCCGCTCCCAGTAGGTGGCCACCTAGACCTCCCGACCGCCCCTCAGGGGCACCAGCGCGTCCGCGCGCGCCTCGCGCTCGGCCTCCTTGCGGCCCATCTCCTCCCTTGGGCCGTCCACGCACGAGAGCACCGAGAGCTGCGTCTCCTCGGACGTGATGCCCGAGAGGTTCGCCGCGACCTGGCTCTCCTCCAGGAGGTTGGCCGGGACGTTGCGCGTGAACGTCGCCCTCACGCCCATCCACGCGTCGTCGGGAAGCGGCGAGGCGGCGTAGCCCGAGAGCAGGCGCCATCGCCTGGAGAGGCCGCGCCTGAACTTCCGCTCCTTGACCATGGCGAGGTCGCTCATGGCCTGCAGGCGGTACCTGATGGCGATCCCCGAGCTCGTGTCGAAGCTCTCCGAACTGAGGTCGGCGACCATCGACGTCGTGAATATGAGCCGCTCCAGGCGGTCGATGAGGTGCTCCTGGGTGCCGTCCGCGTCGGGCTTCGACAGGAAGTCGACCACCACCTTGTCGGTCTCCCGGCCCGCCAGGTTTATGATGCGCGAGTTGCGCAGCTCGGTGAGGGTCGTCTCGTCGATCCTCGCGCCGAGTATCTTCAGGTAGGCGTCGGCGTAGTACTCGACGTCGTTCGCCTTCTCGGAGAGCGCCTTGTCATGGGCGTCTATGAGCGAGAGGGCGCCCTCGAAGAGGCCCTGGCGCTCCTCATTGTCCACATACTCGACGACGGGCACGTCCGGGAAGCCGTGCGGGACCGCCTCCCCGAGCGTCACGGACCCCGACCACTCGAAGGGCGTCTCGGCCGACGCGTCGTAAAGCGTGCCCCTTACCGTGTCGGGGCGCCCGTCGAAGCGGTTGTCGTCCCTCCAGAAGCGCACGGCGAAGAGCACGCGGCCCTCCACCGTGTCATCGCGGACCAAGAGGCAGTTCATGGGCCCCACCGTCGATGAGCGTGGGAGGGCGTCGCCGTCGCGCCACATCAGCTCGAAGCCGGACCCGTACACGTCGGCGAGCCTGGAGAGCTCCGCGTTGAGGTCGTCCTCGTCGTTGCGCGCGCCCCAGCCCGCGAGCCAGGCGAGCGTCCCGTCGTCGTCACCGGAGAGCCTCACGGGGATGCCGAGGAAGTAGCCGACCATGGTGTCCACCATCTGCCTGGCGTAGTTCGCCACCAGGCGGTTGTCCGGCTTGTACCCGGCCTTGGCGGGCAGGTGCAGGACGTCGTGGTCCCCCTCGTAGGCGCGCCTCAGCCTCGCGAGCCTCGGGAGCTGCCGGATGTGGTAGTCCTGGAGGATGTCGGCCAGGAGCTGGCCGCCCATCTCGGTCCCGGCGGGCACGCGGTAGCCGCCGCACGGCTCGTAGGTCGCGGCGTCTGGCATCATATCCCTCCCCTGAAGAGGCTGATCGTCGGCGCGTCGTCGCGAAGGCGGATCGCGCAGGCCAGCGAGTCGGGCGCGTCGTCGTGCTCGGCGCCCTCGCCATAGTCCATGACCTCGTCCCAGTAGGCGGCCGAGGCCTCGCGCGCGCTGTCCAGGCGCACCAGGTCCGCCCAGCGCCCCCGGGCGTGGGTCGATATCTTGACGAACTTGTTGGCGCTCTCCTGGTACGTGCCCACGGGCAGGCCCAGCCCGCGCATCCTCTCGGCCAGGTAGCCCCTGTCGGCATTGCGCTCGCACCACACGGTGCCGAGCCTGAGGGACTCGTGCAGCTCCATGATGCGGCCCACGCATCGGTCCACGTGCGTCTCGCGGAAGAGCTCGCCGTGGACGTGCGGGCGCCCGTCGTGCCAGGCGATGCACGTGACGGCCGTGCCGTCCGCGCCGCCGTACGCGGCGTCCACGTGCATGAGGCCGTCGAAGAGCAGCGAGCGGTCGGAGAACGTCCCCGGCTCCCCCTCGAACACGGCGCCCTCCATGGCCACGTGGCGAAGCTCGTAGTTAGCGGCGAAGAGGCTGCGCGTCATGGCCCTGCGAAGGCCCTTGGCCTCCTCCCTCGACACCAGGCCCGTCGAGTCCCAGGGCCACCTCTCCGGCTCCGGCATGAGCTGGAAGGCGTCGTCCCTGTGCCAGGGAGTGCCCGTGTTGACTATGCGCCCGCCCCGGTTCCGCACGTTCTGGAGCTCGCGGTAGAACGCCTTGGTCGCCTCGCGCTCGGCCCTGGACGCCCGGTCCCTGAGCGTGACCACGTCGTCGGTGAACACGACGTCGTAGTGCTTGCCGGTGAGCGAGCCGCCGATGCCGTAGCCCGAGAGCTGCGGCAGGTCCGACGCGTTGCACGCCAGGTCGGTCGATATGGCGACGGAGCTCTCGGACGCGACCCTCGCGGGGTGACCGTAGATAACCTCCGTGACCATCGCCGACGTGTCGGACCGGAGCATGCGCGCCACGGCGGCCATGACCTCCTCGACGTCCGGTGACGCCTTGCGGAAGAAGCCCACGGCGAGCCTCGGCCGCGTGACCAGGAGCAGCCATAGGGCCACCTTGACGCACGTGGTCTTGTACGAGCCTCGATGCGCCTGCAGGGTCCAGTCGCCATCGCCGAAAGTCATGTGGCGTATCCAGCCGTCGTGCAGCGGCTCGACCAGGCGGTCATAGCCCATCATGCGGGCGAGCCTGACGGGATGGCCCGTCATGACGCGCGAGAGCGCCCTCGCCCGCTCAGCCGCCATCCCGCATGGCCTCGTCGAGCATGCGCCCGAACTCCTCCGCGCTCTCCCTGGACGGCGCCGAGAGCTCGACGCGGTCGCTCGGCCTCTGGCCCGACGTGTCACGGACGAACTCCGCCGCCCTCGTGTCGCCGTCCATGGCCTTGCGCAGCTGCGCGAGCGCCACGGCCTGCGCGACCGTCATGTTCTTGCCCTCCATGCCGTCCATCGTCTGCGCCGTGGTCACGCCGCCGGGCCTGAGGGGCATGTCCAGCATCGCGCGGAGCGTCTCGCGCATCTCGCGCATCTCGCGGCGCTTCCTCCCCGAGGCCCTGCCCGCCTTGCGCGCGTTCTCTCGGCGCTGGCTCGGTGTTCTCGCCTCGTTCGGGACCAGGTTCTCGGGGTTAGCCACGGTGCCTCGCCGCCCTGGCGTCGAGCGGGCTCACGCGGTTGGCCACGCACTCGGCGACGCCGCCGTAGCGGGCCTCGGCCACGGCCAGGGCGTCCGCGTCGACGCCCAGGGCCATGAGCGCCGCGCGCATGGCGTAGGCCACGCGGGTGGAGTGGCGGGCCGCTATGAGGGCGATCTCCCGGATCGTCATGCCGCATCGCCTCCATACGAGTCGGGGCCCCGTTCCTGAGGCCCCCGCGAAGATCCCACGATACCCTTGTACCACGTCCTCCCCGGCACGGGGCGGCACGACCCGGCACGAGGCGGCAAATTCCCTAGCCCTCGGCAAGCCCGAGGCCTCGTATGACCCTGCCGACGCCGTAGGCGTCCACCGCGTCGCAGGCCACCGAGACGGCGTCGCGGCACCACCGCTCGCTCATGCCGCAGGCCTCGGCAACCTCGGCCCAGGTCGCGGCGGCGCAGTAGCGCCACCACAGGCAGTCGGCGTAGGCCGAGCCCAAAAGCGAGCAGACGCCGCCCGAGCCCGTCTGGTCGGAGCCGTAGATGACGTCGCAGGCCTCATCGATGATGGCGTAGTCGGCCTCGACGCGCGAGCGCATGCGGGCCTCGTAGTCCATCCTCTCGTCGGTCGCGGCCATGGGGTCGGCGACGCGCCCCGGAGAGGTGCCGGGGCGGTAGGACTGCGCGCGCGGCCCCTCCCTGGAGGCCATGCGCGCGAGGGCCCGCCTCGTGCGCTCCGCCTCGATCGCCGAGCGCCTCGCCGCCTCCATGAGGTCCCTCGCGTACGCCCACTCGCTCATGAGCCGATCGCCCGGTCGGTTTGAGTAGGTTCGAGTAGGTTCGAGTAGGTTCGAGCCACGGTCGCGGTCATCTTCCGTCCTCCCTCGTCCACTGCTCCGCCATCGCCCTCGCGATGCCCGGGTACGTCCTTCCCCTGAGCCTCTGCCTGTCCGGCCCCGGGGCCATGTGGTGCACCCGGTGCGCCATGGCGTCGGGGAGCCGCGCCATCTCGTCTGACACGTCATGCGTCGGCACGAGCGGCGGCAGGCCCCTGAGCCACAGGCACGTGGCCTTGGTCTCCGGGTGGCCGAACTGCCACGGCTGGATGACCTGGTCCGGCTTGCGGTACAGGCGGCTCATGATGCCGACCGGGTTCTCCACCGCCACCCTCGGCACGTGGTCGAGCGTCGCGAGGGCGAGGAAGAGCCCGATCGCCGACTGCTGCCTGCCGTCGCGCCTCTTCTCGCCGAACCACCTGGCGCCGGAGCACGCGAGGTGCGTGCACGGCGGGAAGGCGATGACCATGTCCCACGCGAGCTTGGCGACCTCGACGGCGTCCGCCCGGACGTGCCACTCCGGGTGCGCGCCGCCCGTCGGGAGCAGGTCGCAGCTGTATGCCTCGTGCCCGAGCCTTCTGAGCTCCGACGTGACGGCCTGCGACTCCTCGCAGGCGCAGAGGACCCTCAT

Protein sequences of DBSCAN-SWA_6

>NZ_CP012069|2340091:2353324|2352171_2352657_-|WP_157051501.1|DBSCAN-SWA
MSEWAYARDLMEAARRSAIEAERTRRALARMASREGPRAQSYRPGTSPGRVADPMAATDERMDYEARMRSRVEADYAIIDEACDVIYGSDQTGSGGVCSLLGSAYADCLWWRYCAAATWAEVAEACGMSERWCRDAVSVACDAVDAYGVGRVIRGLGLAEG
>NZ_CP012069|2340091:2353324|2343183_2343720_-|WP_050341096.1|DBSCAN-SWA
MPEPDYSKNNDSGAYCKFDGGASATDGAYVLTCIFNSVGDKLLAIDGEKDSKLSLSAETVSYSTKDRRGSWQTSRPSTRSWELSLETVHVMDAESNRLIRQAFDNGSVLCVKQVYDDERDYPPRGGGLAFVTKYEDDSPSDDVISISVTLTGAGKWTWFDLDAEAKGKATAKPSNRGR
>NZ_CP012069|2340091:2353324|2344555_2344876_-|WP_157051500.1|DBSCAN-SWA
MAELFELADTGRRDRLGNRVTERRSLGRVRARAAPWTQTAAAEEGNGYLACDLTLVTTAALATVRRAALVRFPATGGDARAYEVVQVSDVGRRRAVHCARQKGEMV
>NZ_CP012069|2340091:2353324|2351458_2351857_-|WP_050341116.1|DBSCAN-SWA
MANPENLVPNEARTPSQRRENARKAGRASGRKRREMREMRETLRAMLDMPLRPGGVTTAQTMDGMEGKNMTVAQAVALAQLRKAMDGDTRAAEFVRDTSGQRPSDRVELSAPSRESAEEFGRMLDEAMRDGG
>NZ_CP012069|2340091:2353324|2347339_2348827_-|WP_050341110.1|capsid|DBSCAN-SWA
MATYWERRMAEADAAMGRDERVVAKRVARAYEREMADLSREIAGYYERYGEDGILRYRDMLESMDPSDRDLLMRDCDRFAAEHPDLADMVAIRKDAYKLDRLEGLQESARQHHARATAEAAEGLDEHFARQAARGANAVAEAMGYGRGFHALDDDTIRRFVGTRWASGKSYSEAIWGDSERVAAWVQDDMAKALARGESWRSLCDELSRRFVGVSERDVMRLVVTEGTYVSRQAQLAELAREGFEEYRVEPVGDERTCEVCSALVGKAFPIDGARVGATLPPIHPRCRCQIAPAVDDWDAWIRDQVDRRQAEVAARRMTEGGERAKGARAVQDECSRIESDFGRVWRDYRASGKSREGYDETVNAYLASISDGRVSAEYRAKPKAKEIQAATWLARNGHEVRFNYESSIPGSRTADMTVDGAPYELKRLGTHNAHKAKVRIGEAARQCSNIIVDLSLRTLTGEQEEEVLRAMASKKDIDAIIALSDVFERVFRRQ
>NZ_CP012069|2340091:2353324|2346177_2346780_-|WP_050341106.1|DBSCAN-SWA
MAGQEGQQVQASGDGAQQQDQAGAQQGANQQGATQQQARYTDADVDAIISKKFAKWREQHEAKVAEAAKLAEMNATQRAEYERDQLQRRLDELEREKSVSGMVAESRRQLSDRGISVPDELVGTLVGETAEDTKRAVDAFADAFEGAVDAAVRARLSGTAPRSGGAAKSPTRVDILKIEDTEARQRAIREHPELFFTSRQ
>NZ_CP012069|2340091:2353324|2350179_2351469_-|WP_050341114.1|DBSCAN-SWA
MAAERARALSRVMTGHPVRLARMMGYDRLVEPLHDGWIRHMTFGDGDWTLQAHRGSYKTTCVKVALWLLLVTRPRLAVGFFRKASPDVEEVMAAVARMLRSDTSAMVTEVIYGHPARVASESSVAISTDLACNASDLPQLSGYGIGGSLTGKHYDVVFTDDVVTLRDRASRAEREATKAFYRELQNVRNRGGRIVNTGTPWHRDDAFQLMPEPERWPWDSTGLVSREEAKGLRRAMTRSLFAANYELRHVAMEGAVFEGEPGTFSDRSLLFDGLMHVDAAYGGADGTAVTCIAWHDGRPHVHGELFRETHVDRCVGRIMELHESLRLGTVWCERNADRGYLAERMRGLGLPVGTYQESANKFVKISTHARGRWADLVRLDSAREASAAYWDEVMDYGEGAEHDDAPDSLACAIRLRDDAPTISLFRGGI
>NZ_CP012069|2340091:2353324|2351849_2352047_-|WP_050341118.1|DBSCAN-SWA
MTIREIALIAARHSTRVAYAMRAALMALGVDADALAVAEARYGGVAECVANRVSPLDARAARHRG
>NZ_CP012069|2340091:2353324|2340091_2342488_-|WP_050341090.1|DBSCAN-SWA
MSDYTLSAKITADSSGFEAGVQGAQSSLDALRAKCSETSSAASSEVGRAADATGSAWERARDRASSALGRMGSGAGAALGAVRENATQLVGALGSIGQAGATAVAGIAVKGGFDRALAIDNAKKKLAGFGHDAADIQSIMDSATTAVRGTAYGLGDAATAAATLSAAGIRSGEDMTNSLQAVANAAAASGRGFNDVGVIFSSVAARGKLMGDDMLQLTSSGVPVLQLLADHLHKTTAEVSDMVSSGQIDFKTFSDAMREGLGDAAKSSGDTLEGAVANVGSALSRMTEPLATPVIQGVVGLMKQLGPAIDGVSSALGPVMPALAPVVAGLAAFAASGLAPVLAGLPMVGPLLGPVTSLLSALGGPVGIAAAALVGLTAVCPPLQEAFGSLLDSLGELGRAVIDVVGPAAKAALDALQPLVQALGQGLAAAIGAAAGVISELARGLSGMAEGGGSALDGLRPVAEWVQSTLGPVVESARGALSVVSQTLGEVAASAQATLGPSLQTLAGLVASVAQALAGVLGPALQLVASLALNALGAAFQVAGALVSGAMQVVAGAVTAAVGVIETVLGVLVGVFTGDWSMAAEGARTAMGGMQEAVLGILNGLSGAVVGVLNGIVGHFGAILGGVPGIAEGALSALSSLVGGRMDGLRDAVAGGLDAVAGLFRGLHIEWPHIPLPHFSVSGELNLDPAHFSVPSIGIDWYARGALLTRPTLFGVAGGRAMGGGEAGPEAVVPVDRLVGFIVEALGQLGVGGGQDGVTVNVSSLVVREEADVERIADRLNTLIGRSRRAGGTTWATQ
>NZ_CP012069|2340091:2353324|2342866_2343172_-|WP_050341094.1|DBSCAN-SWA
METTTFEWDGTTWELAYAARRIDMLEAALKRSVIEVLSRTPTLAEARSLMAYGMREAGTSAWAAPGRAMGIAGDYVAERGLSSAMEMVSSAILRDCGFLFR
>NZ_CP012069|2340091:2353324|2343750_2344167_-|WP_050341098.1|DBSCAN-SWA
MSRRALRRLSPVDLVAAVVARVSGGTGVRCVLDPGDERSPLYSVSLTGMRPERSKSLRIDVYELQVHAISAPSRTSEAALSMVWALQEAMEADVELPRPFCLVRQDDMGLQSVKRDPTGEWHAIVAYEVTVSYGLMVK
>NZ_CP012069|2340091:2353324|2346893_2347151_-|WP_050341108.1|DBSCAN-SWA
MPTVTIWHATWCAPCKGTIERVVPRLREEGVEPALADVDLRPCAARDRHVDYLPTFTVDDGDEELLRCRGHPTEEAIERIVGLCG
>NZ_CP012069|2340091:2353324|2344884_2345238_-|WP_050341104.1|DBSCAN-SWA
MAILERVRARLDAWEDVPSDGWLSEAIRSLSDRACARMGVASLPAPAESIVVDATVKAVNRRFDEGISSETEGQGTGASMSVAFSDDLLAEYDRELSALADMARADGTSLLPSVRFL
>NZ_CP012069|2340091:2353324|2352724_2353324_-|WP_050341122.1|DBSCAN-SWA
MRVLCACEESQAVTSELRRLGHEAYSCDLLPTGGAHPEWHVRADAVEVAKLAWDMVIAFPPCTHLACSGARWFGEKRRDGRQQSAIGLFLALATLDHVPRVAVENPVGIMSRLYRKPDQVIQPWQFGHPETKATCLWLRGLPPLVPTHDVSDEMARLPDAMAHRVHHMAPGPDRQRLRGRTYPGIARAMAEQWTREDGR
>NZ_CP012069|2340091:2353324|2342498_2342762_-|WP_157051499.1|DBSCAN-SWA
MAARLGWTPEQWGSLTDAQRVLLARAVEDRDVRATEAVRDAVANALANALRRKGGDPLPLYEDASRGQAMGHGEAVGKMRDIAAHMG
>NZ_CP012069|2340091:2353324|2345249_2346158_-|WP_050341105.1|DBSCAN-SWA
MPNTPVSYPEAGGTKSTDLAPEISIDYVNRFTTGVRRLQRLLGLSDLMPVADGGTVKTYKYTTDIKDGNVAEGEYIPLSKVSRTLDQTHAINLRKWRRNTSAEAIQSKGRDRAINGTDAKFVSGVQGLVKADLLSAITGTTKTAPAGAGLQAALASMWGALNTIFEDYDGFGDIDDGAVSPFVFFVNPTDVAKYLGTATVTTQSAFGMGYLKDFLGLGTTFTSAKVTAGSVFGTAARNVVVAYTPANGSGLSQTFGLTSDATGLVGMTHSVVTTNATIDTLLMGGMKVFPEISDAVLKGTIS
>NZ_CP012069|2340091:2353324|2348827_2350183_-|WP_050341112.1|portal|DBSCAN-SWA
MMPDAATYEPCGGYRVPAGTEMGGQLLADILQDYHIRQLPRLARLRRAYEGDHDVLHLPAKAGYKPDNRLVANYARQMVDTMVGYFLGIPVRLSGDDDGTLAWLAGWGARNDEDDLNAELSRLADVYGSGFELMWRDGDALPRSSTVGPMNCLLVRDDTVEGRVLFAVRFWRDDNRFDGRPDTVRGTLYDASAETPFEWSGSVTLGEAVPHGFPDVPVVEYVDNEERQGLFEGALSLIDAHDKALSEKANDVEYYADAYLKILGARIDETTLTELRNSRIINLAGRETDKVVVDFLSKPDADGTQEHLIDRLERLIFTTSMVADLSSESFDTSSGIAIRYRLQAMSDLAMVKERKFRRGLSRRWRLLSGYAASPLPDDAWMGVRATFTRNVPANLLEESQVAANLSGITSEETQLSVLSCVDGPREEMGRKEAEREARADALVPLRGGREV
>NZ_CP012069|2340091:2353324|2344163_2344559_-|WP_050341100.1|DBSCAN-SWA
MSAVSVTLDDGGLGERLDELRRVTCESVVRATVSQMAEDLKAITPRETGSLLNSLRQRVEDASTGYVGYVADYAPHVEYGHRQNVGQYVPRLGKALRAPYVEGQHFLSEEVAAARSVMRRRFDEHMRRQGL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_050341090.1|2340091_2342488_-	tape measure protein	A0A1D8EU70	Propionibacterium_phage	3.5e-57	60.1
WP_157051499.1|2342498_2342762_-	hypothetical protein	NA	NA	NA	NA
WP_050341094.1|2342866_2343172_-	hypothetical protein	NA	NA	NA	NA
WP_050341096.1|2343183_2343720_-	hypothetical protein	NA	NA	NA	NA
WP_050341098.1|2343750_2344167_-	DUF5072 family protein	A0A097PAW5	Streptococcus_pyogenes_phage	9.4e-19	37.3
WP_050341100.1|2344163_2344559_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_157051500.1|2344555_2344876_-	hypothetical protein	NA	NA	NA	NA
WP_050341104.1|2344884_2345238_-	hypothetical protein	NA	NA	NA	NA
WP_050341105.1|2345249_2346158_-	hypothetical protein	D2IYW7	Enterococcus_phage	3.2e-48	40.5
WP_050341106.1|2346177_2346780_-	DUF4355 domain-containing protein	E8ZDF3	Streptococcus_phage	4.4e-09	47.0
WP_050341108.1|2346893_2347151_-	hypothetical protein	NA	NA	NA	NA
WP_050341110.1|2347339_2348827_-|capsid	minor capsid protein	A0A097PAV7	Streptococcus_pyogenes_phage	3.7e-09	36.4
WP_050341112.1|2348827_2350183_-|portal	phage portal protein	A0A097PAT2	Streptococcus_pyogenes_phage	1.4e-108	48.7
WP_050341114.1|2350179_2351469_-	hypothetical protein	R9QM30	Lactococcus_phage	5.6e-94	44.7
WP_050341116.1|2351458_2351857_-	hypothetical protein	NA	NA	NA	NA
WP_050341118.1|2351849_2352047_-	hypothetical protein	NA	NA	NA	NA
WP_157051501.1|2352171_2352657_-	hypothetical protein	NA	NA	NA	NA
WP_050341122.1|2352724_2353324_-	hypothetical protein	A0A2H4J4W2	uncultured_Caudovirales_phage	1.2e-67	59.1

Sequences of DBSCAN-SWA_7

Nucleotide sequences of DBSCAN-SWA_7

>NZ_CP012069|2357394:2363439|DBSCAN-SWA
CTCATGCCCGCTGAACATCGCCGCCCCCATCCTCGACGGGGACCCACTCGATGGCGCCCTCGTCGTAGGCGGCGAGGCTCGCCGCGATCGCCTCGGCCGGGGACGCCCTCGGCGGGCCGGCGTTGAGGTAGCCCTCGAACTTCGTGGCGTTGAACAGCGTCTCCGGACGCAGGTACCTGCGCATCCTCTCGTCGCCGAGCCACCTGGCGGCCATGTTGTCGATGACCCGCTCGCAGTCTTCGGCGCTGAAGCCCTCGCGGAGCCTGGCCCCGACGAGCTGGCGCGACTTCGCGGAGCTTGGCCGGTACGCCGTGCCGCAGGCGGCGTTGAGGTGGGCGATGACGCGCTCGGTGGCCTCCTCCGCCCCGTCGCCCCCCTCCCCCTGCACCCCCTCCCCCTGGGAAGGGGATCTGGAATAGGAATGGGAATAGGAATCTTGATAGCTTGGCGTTTTGCTTTCCGATTTTTCGGAGTTTTGCTTAGCCGTTTGCTTATCGCTTTGCTTAGCCGTTTGCTTAGCCGTTTGCTTATCGCTTTGCTTAGCCGTTTGCTTAGCCGTTTGCTTATCGCTTTGCTTAGCCGTTTGCTTAGCCGTTTGCTTATCGTTTTGCTTATCGTTTGCTTCCGGCTCCGGTTCGGCATCACCTTGCCTGGATGGCCTTCCGCCTCTCCTGCCCGCCTCCGAGCGGGTGCGGGAGTTCTCGAGCGTCGGCCGGATCATCATGAACATCCCCTCGGAAATCCCGTCAAGGTCCGGCTCCTCGCCGTCATGCAGGAAGTCGATGACGGCGAGGAGCAGCATGGCCCTCTCCTCCCTCGGGAGTGCCTTTGACCCGTCGACTATGCTGTCGAATATCTGCATGGCCGCCTACCTTCCCTCGCGTCCCGTCGGGTGCATGCGAACCCCCCTAGAACGGAATGTCCTCGTCGTACACGCCCTGAGCGGGCGGCGCGTAGGCTGGTGCCGCCTGCGGCCGTGGGGCCGCCTGCGTCGCCTGAGGCGCGTACGTCCGTCCCTGCGGGGCCTGCTGTGGCGCCTGGTTGGTCGGCTGCTGCTGCGGCGTGAGGAACACGACCTCGCCGGCGACGACCTCGAGCTTCGAGCGGTTCGCGCCCGTCTGCTTGTCCTGCCACTGGCTCCAGCGGAGCCTGCCCGAGACGGCGACCTTGGAGCCCTTGGCCAGGAAGGGCGCTATGGCGTCGGCCCGGCTGCCGAACACGACGACGTCCACCCAGTTGGCCCGGTCGCGCCACTCCCCGGTCTGCTGGTCCCTTACGCGGTCGTTGACCGCCACCGAGAGCGAGAGCACCGACGTGCCCGTCGGCGTCACGCGGAGCTCGGGGTCTCGGCCGAGGTTCCCCGATATGGACACTGAGTTGATCGACATTTCCCATCCTCCCTAGAACTCGTAGTCCTCGTCGGCGAGGCCGGACTCCCAGCCCGCCTCTGCGTCCTGCGCCGCCTGCGTCGCCTCTGCCTCCCGGCCCATCGCCTCGGCCTCGCCCGCCATCTCCGACTGCTCGGAGGCCTCGGCCTCGTAGGCGACCGGGTCGCACGCCTCGGCGGGAGGCTCTGGCGCCCGGTCGTCCCCCGGCATCTCGGAGCCGTCGTAGATCCCGCCGTACGCGCCCGGGTACGCCTCGCGCAGCGCCTGCACGAGCGCCACCTTGCGGATCATCGTCGCGGGCTTCGTCTTCCAGAGGCTGCGGTGCTGGTCGTACTCGTCGAGGCTGACCTCGGAGCGGCTCGGGTGGGCGCGACCCTTGTCGTAGACCTCGGCCCACCCGCCGACGAGCCTCTCGGTCTGGCGCCCCCAGATGGTCCCCTCGCGGTACGAGAGCCCCGACGCGCCCCTCGCGACGACCACGATCCCGGCCCTGATGCCGTCGAAGCCGGGCTGCTGCGTGGCCGTGCGCACGAAGTAGTCCTTGGAGACGATGACGCTGGCCTCGACCCTGCCGGTCTTGCCGTTGCGGTACGCCGTCATGTAGGCGTCTCCCGCCAGCGGGTTGAGCCTCCTCGCCTGGCACTTGGCCATGAAGGAGAAGAGCTCGCGGTCGTCCACCTGCTGGCCGCCCGTGACGATGTACTTGGCCACGATGCCGGGCGAGAGCCTGACGTCGGAGCCGTCGGATGCCTTGAACTCCACGATCGCGCCCTCCATCACCGCTCACCCACCTTCCGGCCGTGCACGCCGTCGATCGCGCGCATGGCGGCGACGAACTGCCCGACCACGGGCTCGGGCACGGTGACCTCGAAGACGAGCGTGCGGGCGGGGCCGGATGCCTGTCCCGGCTCGGGGGCGGGTCGCGTCGGCTCCTCCTCGTCGGGGTAGGGGTCGGACGTCGGCGTGGGGTCCGGCGCGTCCTGGCCGATCGCCATGCGGTACATCCTGGCCCTCTGCGCCTCGGCGAGGGCGTCGGCGCGCCTCGCCTCCTCGCGGGCCCTCTCGGCTGCCTCCTCCTCGGCGCGCTCGCGCTCGGCCGCCTCGCGCATCGCCCTCTCGGCCTCCTCGGCCTCGCGCCTGCGCCTGGCGTCCTCCTCCAGGGCCTCCCTCTGGCGGCGCCTCTCGGCGGCCCGGCCCATGGCCTCGCTCATGTCGAGCGTGGAGAGGTAGTCCTGCTTGAGCGCCATCCTCTCCTCGTCGTCCATGTGCTGGGCGTCGATGGCGGCGAGGTCGACCTCGATGGAGCGGACGCGGCGCGTGAGGTCCTCCTTGATGGCGACCTCGTTCGTCCCGTAGTTCCGCCACCTGCCCTCGGCGCCCCAGCGGTCCAGGATCCTGGAGAACGGCACGGCCTCCACCACGACGCCGCCCTCCTCGACGTACCAGGCCTCGATGGCCTGCAGGCGCGACTCGACGACGAGGGCCTCCCAGGCCCTTATGGCATCGCGGTACCCCTCGTCCACGCCCGAGAGCGGCGCGAGGAGGTCCCTCACCTCGGCCTCGAACTCGCGGACGGCGTCCTTGATGGCCCCCACCTGCTCGCGCCGCGAGTCCTCGACCTCCTTGATCGCCTTGCGCGCCGCCGTGCGCGCCCTCTTGGAGTCGCGGTAGTCCTGCGCCGTCGTGATCTCGTGCGGCGAGTACTCCCTGGCGAGCCTCTCGACCCTCTCCCTCTGGTCACGGAGCCACTCCTCGGCGCCCGCCAGTATCCTCGGGGGCTCTATGAGCGTCGGCTCGACCTCCTCGGCCTTCCTCTTCCTCGTGGTCATCTCTTCTCCTTCCTCTCGACGTCCCTGACCTCCACGACCACGCGCGGCCAGTCGGGACTTACCAAAAACCTGTGCTCTATGCCCGTGACGTGCGCCTGGTCGTCGCCTGCGATGACCTTGGCCATGACCAGGCCGTCGAGCACGAACTTCGCCGCGAACGCGACGTTGTCGAGGTCGCGCCTGGCGTCCCGCTCGTGCCACTCGCACGTGACCTCGACGGGCCCCTCGTGCCCGTGCGCCCCCGCCGCCCGCGCGTACCAGGCGACGAGCTCGGTCTGCTGGCGCTTGAGCCTGGCGCCCATCGCCCGGTGGGAGCGGCAGGCCCTCGTGTACTCGTTGAGCCCCACGAGGCGCCCGGGGATGATGATCCGGTCCGGCGTCATGACGCGACCATCGCCAGGACGAGCGTGACCAGCGCCACGACGACCAGGGCTGCCATCACCGGGGCGTCCGGCCGGTCTATGAGCATCCGAGCCACCTCCTCAGCTCGGCGTCGAGGACCCGCCAGCCCCTCTTGGCGCCACGGGGCGCCACCACCTTGAGGTCGCCGTCCCTGACGCTCCTGTAGAGCGTCCTCAGGGGCACGCGCGTCACCCTGGACGCCTCGGCGAGCGACCACGTGGCGAGCTCGCCGAGCCTCTCTCCCTGCACAGTTGCTGTTGTTGTCATTCCGTCTCCAATCCGTGTGTCTTGCGAGCGCCTGGGGCGCGCGGCCGGGTCAGGGAGGCCTCGGGGCCGAAAGGAGGTGCCCGCCGGCGCCAGTGATTGCCGGCGTCGCCCTTGCGGTCCGCCCCCGCGCTATGCGGGACGCGGTGCGGAGAGCCGGCCGCGCCTCCCGGGCGCTCGCGCTGGTTCGCTACATCTCGTACAGGTCCTCGACCTCGCACCCGACGGCCCTCGCGAGCGACGCAAGCGTCCCCAGGCTCGCCTGCGCGATGCCCTCGTCGGTCGTCCAGCGCCAGACGGAGGACTTGTCCACGCCGAGCCTCCTCGCGACCTCCTTCTGCCTCAGTCGCCTCTCGGCGAGCACGACCTTTAGCCTCGACCTCATCTCCCACCTCCAATCTTTGGTATCAGGAACTCAGGTTCTCGCAACATGCGGTATACTCCCTATGTAATAAGGAGGCGAGGGGAGGTGATCGCATGGCCAAGAACACGAAGCAGACCTCGCGCAAGGCGGCGAGCGCGGCGTCTAGGGTCCTGAGGGACGGCCGCACGGGCAAGGCGTCGAAGTCGGCGGCAGGGAGCGCCCTGTCCCAGACCCCGAGTCGGAGGAAGTAGGGACCCCGCCCCTGCCCGCGAGTGCCTGGTGCAGCCCGATCGCGAGCCCCTGCACCAGGTGCTCGTCCCCGTACAGGTCCGCGTACCCGAGCTGGTCGAGCAGCGCGTGCACCAGCTCGTGGAGGAAGACCTGCTCCCTCTTCTCGGCCGACAGGCCCGACGACAGCCGTATGAGCTGTCTCGCCGGTGACACCGACCCGTCCTCGCCGTCCATGTCGGCGGTCTCGACCGCGTATGCCAGACCGAGGACGCTCACGCTCCGTGGGACCTCGACCGCCATCAGCGGTCCCCCGCGATCCCGAAGTGCACGCAGGCCTCCTTCGCCTCCGCCACCCAGGCCTCGCGGGCGTGCGCCGCCACGAGCGCGTCGCACTCGTAGAGCGGTCCCCCGTAGCGCTCCCCGCGCGCGGAGTCCCACCCGTGCCCGGAGCGGTCCCCGGGCGTGTACATCCAAGGCGTGCCGTACTCCCGCACGCAGGGGTTGCCCTCCTCGTCCGTGGAGAGCGCAAAGTCGTGGCGCCCGTAGAGCTCGGGCATCTGGTTCTCGGTCATGTCTGGTTCCCTTCTTTCTGGTTTGTCTTTAGCTTTTGCGCATCAGGTATTCCGGCTCTCGTTGATAGAGTTTTGAGAGCTTGACCACTACCGTGCCGGGCGGGTCTACTTTCCCAAGCTCATACAGAAGGACTGAATGTGCGGATCGACCGATCCTCTTTCCAACCTCCTCAGCAGACATCCCAAACCGAATTCGTTCTGCCCTTAGGTTTCTTCTCACGTCATCACCTCCAGAATACCAATGTTTGTTGGTGTCTTACAGTTAGAGAATATATCTTTTTGTTGGTTCTCGCAAGCAAAATTTTGTGTAAATATCTACATATGTTGGTTTATACAAGGGAGATTGGTATGAAGTACCCCAACAAAATAAAGGCTGCTCGAACTCATGCGAAGCTTACTCAGGCTGATCTTGCCGAAATAGCCGGAATCACTGTCCAAGCCCTTCAAAATTACGAGTACGGCGCTAGGGACGTAAAATCGAGCATTCTTTCAAAGATTTCAGACGCCACGGGAAAGTCTATGACCTACTTACTTGGATTAGATGATGACCCGTCGTTTGCAGGAAATTTTGAAAGGGGAATCACGCATCGTATTCCAGTGCTTGGACGCATCGCCGCAGGCGAGGCGCGCGAGGCAATCCAGCAGGCCGACGAATGGCACGCCACTCGCGATGATCTGTGGCGCGGCCATGAGAGAGCGTTCTGGCTGGTCGTGGCGGGGAACTCCATGAACAGGCTTTTTCCGGAGGGTGCGTTGGTGCTTATAGACCCCGACATGGAGATCCGTGACGGGGACGTCGGAGCCGTTTTTGTCAACGGGGACGATGCGACGCTCAAGCGCGTGTTCTACGACGGCGACGCGGTAAGGCTTCATCCCGAAAGCTATGACTCCGAGTACAGGGATCGTACAATAGATCGCGCTGACCCAGACGCTCCCGAGTTTCGATCGATAGGACGCGCCATCAGCTATGCCGCGCCAGATGGATGGCGGGCGTAG

Protein sequences of DBSCAN-SWA_7

>NZ_CP012069|2357394:2363439|2357394_2358255_-|WP_050341144.1|DBSCAN-SWA
MQIFDSIVDGSKALPREERAMLLLAVIDFLHDGEEPDLDGISEGMFMMIRPTLENSRTRSEAGRRGGRPSRQGDAEPEPEANDKQNDKQTAKQTAKQSDKQTAKQTAKQSDKQTAKQTAKQSDKQTAKQNSEKSESKTPSYQDSYSHSYSRSPSQGEGVQGEGGDGAEEATERVIAHLNAACGTAYRPSSAKSRQLVGARLREGFSAEDCERVIDNMAARWLGDERMRRYLRPETLFNATKFEGYLNAGPPRASPAEAIAASLAAYDEGAIEWVPVEDGGGDVQRA
>NZ_CP012069|2357394:2363439|2358793_2359558_-|WP_050341149.1|DBSCAN-SWA
MEGAIVEFKASDGSDVRLSPGIVAKYIVTGGQQVDDRELFSFMAKCQARRLNPLAGDAYMTAYRNGKTGRVEASVIVSKDYFVRTATQQPGFDGIRAGIVVVARGASGLSYREGTIWGRQTERLVGGWAEVYDKGRAHPSRSEVSLDEYDQHRSLWKTKPATMIRKVALVQALREAYPGAYGGIYDGSEMPGDDRAPEPPAEACDPVAYEAEASEQSEMAGEAEAMGREAEATQAAQDAEAGWESGLADEDYEF
>NZ_CP012069|2357394:2363439|2359557_2360610_-|WP_050341150.1|DBSCAN-SWA
MTTRKRKAEEVEPTLIEPPRILAGAEEWLRDQRERVERLAREYSPHEITTAQDYRDSKRARTAARKAIKEVEDSRREQVGAIKDAVREFEAEVRDLLAPLSGVDEGYRDAIRAWEALVVESRLQAIEAWYVEEGGVVVEAVPFSRILDRWGAEGRWRNYGTNEVAIKEDLTRRVRSIEVDLAAIDAQHMDDEERMALKQDYLSTLDMSEAMGRAAERRRQREALEEDARRRREAEEAERAMREAAERERAEEEAAERAREEARRADALAEAQRARMYRMAIGQDAPDPTPTSDPYPDEEEPTRPAPEPGQASGPARTLVFEVTVPEPVVGQFVAAMRAIDGVHGRKVGER
>NZ_CP012069|2357394:2363439|2361069_2361279_-|WP_157051504.1|DBSCAN-SWA
MTTTATVQGERLGELATWSLAEASRVTRVPLRTLYRSVRDGDLKVVAPRGAKRGWRVLDAELRRWLGCS
>NZ_CP012069|2357394:2363439|2362791_2363439_+|WP_050341161.1|DBSCAN-SWA
MKYPNKIKAARTHAKLTQADLAEIAGITVQALQNYEYGARDVKSSILSKISDATGKSMTYLLGLDDDPSFAGNFERGITHRIPVLGRIAAGEAREAIQQADEWHATRDDLWRGHERAFWLVVAGNSMNRLFPEGALVLIDPDMEIRDGDVGAVFVNGDDATLKRVFYDGDAVRLHPESYDSEYRDRTIDRADPDAPEFRSIGRAISYAAPDGWRA
>NZ_CP012069|2357394:2363439|2361466_2361661_-|WP_050341155.1|DBSCAN-SWA
MRSRLKVVLAERRLRQKEVARRLGVDKSSVWRWTTDEGIAQASLGTLASLARAVGCEVEDLYEM
>NZ_CP012069|2357394:2363439|2360606_2360993_-|WP_050341151.1|DBSCAN-SWA
MTPDRIIIPGRLVGLNEYTRACRSHRAMGARLKRQQTELVAWYARAAGAHGHEGPVEVTCEWHERDARRDLDNVAFAAKFVLDGLVMAKVIAGDDQAHVTGIEHRFLVSPDWPRVVVEVRDVERKEKR
>NZ_CP012069|2357394:2363439|2361802_2362171_-|WP_050341157.1|DBSCAN-SWA
MAVEVPRSVSVLGLAYAVETADMDGEDGSVSPARQLIRLSSGLSAEKREQVFLHELVHALLDQLGYADLYGDEHLVQGLAIGLHQALAGRGGVPTSSDSGSGTGRSLPPTSTPCPCGRPSGP
>NZ_CP012069|2357394:2363439|2362471_2362663_-|WP_157051505.1|DBSCAN-SWA
MRRNLRAERIRFGMSAEEVGKRIGRSAHSVLLYELGKVDPPGTVVVKLSKLYQREPEYLMRKS
>NZ_CP012069|2357394:2363439|2358301_2358781_-|WP_050341146.1|DBSCAN-SWA
MSINSVSISGNLGRDPELRVTPTGTSVLSLSVAVNDRVRDQQTGEWRDRANWVDVVVFGSRADAIAPFLAKGSKVAVSGRLRWSQWQDKQTGANRSKLEVVAGEVVFLTPQQQPTNQAPQQAPQGRTYAPQATQAAPRPQAAPAYAPPAQGVYDEDIPF
>NZ_CP012069|2357394:2363439|2362170_2362443_-|WP_050341159.1|DBSCAN-SWA
MTENQMPELYGRHDFALSTDEEGNPCVREYGTPWMYTPGDRSGHGWDSARGERYGGPLYECDALVAAHAREAWVAEAKEACVHFGIAGDR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_050341144.1|2357394_2358255_-	conserved phage C-terminal domain-containing protein	G7YZ75	Streptococcus_phage	2.0e-15	46.2
WP_050341146.1|2358301_2358781_-	single-stranded DNA-binding protein	A0A1P8VVD7	Erythrobacter_phage	4.4e-12	40.6
WP_050341149.1|2358793_2359558_-	phage recombination protein Bet	A8ATK8	Listeria_phage	4.8e-29	37.1
WP_050341150.1|2359557_2360610_-	DUF1351 domain-containing protein	NA	NA	NA	NA
WP_050341151.1|2360606_2360993_-	hypothetical protein	A0A0A7RTR1	Clostridium_phage	1.7e-14	36.4
WP_157051504.1|2361069_2361279_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_050341155.1|2361466_2361661_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_050341157.1|2361802_2362171_-	hypothetical protein	A0A1Q1PVT7	Staphylococcus_phage	6.8e-05	34.5
WP_050341159.1|2362170_2362443_-	hypothetical protein	NA	NA	NA	NA
WP_157051505.1|2362471_2362663_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_050341161.1|2362791_2363439_+	LexA family transcriptional regulator	A0A2H4J245	uncultured_Caudovirales_phage	6.1e-25	36.6

Sequences of DBSCAN-SWA_8

Nucleotide sequences of DBSCAN-SWA_8

>NZ_CP012069|2483033:2548095|DBSCAN-SWA
CATGTACAGCCAGGAGAGGAGAAGGCTCGCGATAGAGACCTTCATCAAATTCGACCATAGCTATGCTGATACCATCGCCGAGCTCGGGTACCCGACGAGGTCCGCGCTGCGAGCATGGTGGAACGAGTACAAGAGGACCGGCGAGGTGCCCGCAAGCAGGTTTGCCACGAACCCGAAGTACACCGCCGAAATGAGGCGGCGAGCCGTCGAGCACTACCTCGAGCACGGCAAGAGCCTGGCAAGGACGATGAGGGCCCTTGGCTACCCCAAGAGCCGCGAGAAGCTCTGCGAATGGGTCGACGAGCTCGCGCCGGGACGGCGAAGGCACCGAGGTCCGAGGCCCAGGAGGGAGGCGATTTCCCTCGAGAGGAAGGTGCGGGTCGTCGCCGAGCTCGAGGCGAGGGACGGGTCCGCCGCGGAGATAGCCGAGCGACACGGCGTGTCGAGAACGGCACCCTACCTCTGGCGCAGGGAGATGATGGGCGATAATGGCGGGGAACCCGAGAGGAAGGGAGAGCCCGTGAGCAAGAGGTTCGACGACCTGCCCGATGACGTCGAGGTATTGCAGGACATGCTGCGCGAGGCGAAGACGCAGCTCAGGAGGGTGCAGCTGGAGCTGGACGTTCGCCAGGCGACCCTCGAGATAGTAAAAAAAGACCCGGGCGCCGACCCGGAGCTGCTGACCAACGCGGAGAAGGCGGCGATGGCGACGGCGCTGAGGGACAAGTATAAGCTCTGCGAGATCCTGCCTGCGGTGGGCATGGCCAAGAGCAGCTACGAGTACGCGAGGAACGCGCAGCTCAGGGGCGAGACAGAGGAGCATGCCGCTGCCAGGAAAGCCGTGGTGGAGGCATTCGAGGCCAGTGGCGGCACCTACGGCTACAGGCGCATCACGGCGCGGGTCAACGCAGGCAGCGAGCCGGGAGGGCGCGTCGGCGAGTGGACCGTCCGCAGCATCATGGGAGAGGAGGGCCTGGTCGCGAGGGTGGCGAGGAGAAGACGGCGCTACAGCTCCTATGGGGGCGAGATCTCCGAGGCGCCCCCGAACCTGCTTCGCGACGAGCGGGGGAGGCACGACTTCGGGGCCGACGCCCCCAACGAGAAGTGGGTGACCGACGTGACCGAGTTCCGCATCCCGGCTGGCAAGGTCTATCTCTCGCCGATCGTGGACTGCTTCGACGGCATGCCGCTGAGCTGGTCGATCTCGACCTCGCCCGACGCGGAGATGGCAAACTCGTCGCTGCTCGGCGCGTGCGAGTGGCTGCGCGAGGGCGACCGTCCGACCGTGCACTCGGACAGGGGCAGCCACTATCGCTGGCCGGGGTGGATCGGGATTTGCGAGGCGGACGGCCTGGTCAGGTCGATGTCGAGGAAGGGGTGCAGCCCTGACAACGCGAGGTGCGAGGGCTTCTTCGGCCGCCTCAAGATAGAGTTCTTCTACGGGTGCGATTGGAGCGGGGTTACGATCGACGAGTTCATGAGAATGCTCGACGCGTACCTGAGGTGGTACAGGGACGTCAGGATCAAGAGCGACCTCGATTATAGGAGCCCGATGCAGTACAGGAGAGATTTGGGGTTGGCAGCATGAACGTGGGCCAGTTGATAGGGTACCTCAAGGACTACGACGAGGACGAGGAGGTCGAGGTCGAGGTGCGCTTCGGGGAGGCAGGCGAGTCGCGCGCGTCGACCTTCGACGTCACGTTGCTCTCGCGTGGGGAGGTCGGGGGAGGCGACGAGAGCCCCTGGCCGACGATCGGCGCGAACGTGGGGCTCGGGACGATGACAGAGGCGGGGCTCGACCTATTGATCGAGCATGTCAAGGGAATCGACCGGAGATTGGGCTATCATAGGGGTGGTGCCTGATCCGCACCACGTGTCCGGGACTTGGACCATACCCCCTTACCATGCAGCTGGCTCAGCGATCGAGCGAGTCTCGGTCCAAGATTCCCACCGCAGTCCCTATTGTGCAGATTATTCCGATCAACGCCGCCACTGCATAAATGAAGAGAGAGATGTAGCCAAACCACGTGCCGAGCATATCCAAGACGTTCTGCCGGGTGGCAACGAGGGGCCTCAAGCCCGTGTTCTGAAGCGCAGCAGTGAGGTCGTCATCCTCGCCAAGCTTACCCTCTATCTCTGCGCTAATTTCGGAAAGTCTCGATGTGTCATTGGCGATAGCGGACAGGTACATGTAATCACTGCCGGCAAACAGGGGGTTACTGACATTCGTCGCAACAAGTTGGTTAACCTCCGCAGGGAAAGTGGAGAAGAGCTGCTCTTCCTGTCTATCCAGGATTCCAGAAACCCTTAGTTCGCGTTTCTCACCCTTGACAGTGGCCACCAACCTGTCCCCTATCTTGAGGTCGGATGCGCTGGCCACCGATGCACCTATGAGAACTTCTTCGTCCGTATTCGGGAAGCTCCCCGAATACCCTATATTGAAGTTCGTGAAAAAATCAGCGCTGACTCCCTTGAGCGTTGAGGCGAGTATTCTCTTGCTGTTACCATACACCAAGGACTCAATGCCCACCCCCTTAACGCCAGTAACATTCGACACGTCTTTGACTTGCCTGACGAGGCTGATGTCACGTTCGGTATAGAGACTCTGATACGTATAGTTGAGGGGATTTGCCCCACTACCAAATGCGATCGTGAGGACGTTTGCATCCGAGACTTTCATCTCATCCAACATTTTCGCATAGAATGACTCGGACAGCGCGAGTACTGACGAGATGAGGAGCACTGATATCCCAACCGCAAGTATAGTCAGCCTATTACGTCTTCCGTTGATTTGGTAGTCCCTGCGAGCGAGAAGGAGCAGGCCTGTCTTCATCTGATTTCCCGTCTTTAGGATCTAGCACTAGGATTCTTTGACCCGACGACAACGAAACCGAAGCCGACGCCAGCCCCGAGCTGGCGTTTTTGCTGTCTCCGCGAGACTTGACAAGATTTCTCACATGGATCATGTTTCTAGTGCTATAGTGCTATATCAGAGCATGGGAACCGACGGGCGGAAGGGGGCCCGGGATGTCGTACTTCCTCAAGCAGACGAGGAACAAGAAGGGCACGTACCTGCAGATCTACGAGAGCACCTACGACCCCGGCCGCGGCTACGGCACGCACCGCTCGGTGAGGGCCGTCGGCTACGTCCACGAGCTGGAGCAGTCCGGCATCCCCGACCCGGTGGCGCGCCTCAGGGCCGAGGTGGCGGCGATGAACGAGGAGGCCAGGGCGTCGAGGGCGAGGGAGGGGGCGAGGCTCGTCGGCGACTCGACGCCCGAGCGCCACATGGGCCACTTCCCCGTCAAGGCCCTGTACAGGCGGCTCGGCATCCCGGCCGACATCGGGTACCTGCAGATGGCGTCGGGGTTCCGCTTCTCCCTCGACGGGCTCCTGGAGTCGCTCGTCTGCGCGCGCGTCGTCGCCCCGTGCTCGAAGTCGAGGACCTTCCACGACGTCCTGCCGCTGCTCGGGGAGGAGCCGTCCTTCTCGCTCGGCCAGCTCTACGACGGGATCTCCTACCTCGGCCACGAGTACAGGAAGGTCGTCGAGGCCGCGAACGCCCGCGTGGGCGAGCTGTTCGGCCGCGACACGTCACGCTCCTACTTCGACTGCACGAACTTCTACTTCGAGATAGACCGCGAGGACGGCCTGCGCAGGAAGGGGCCCTCCAAGGAGCGGAGGGCTGACCCCATAGTCGGCATGGGGCTCCTGCTCGACGCGAGGTGCGTGCCGATGGGGCTCGAGATATATCCCGGCAACGAGAGCGAGAGGCCGAGGATCCGGGAGGTCATCGGGGCGCTCAAGGAGCGCCACCACATGACCGGCAGGACCGTGCGAGTGGCAGACAAGGGCCTCAACTGCGCGGACAACGTCGCCGACGCCGTGCTGGCGGGCGACGGGTACCTGTTCTCCAAGAGCGTGAGGCGGCTGCCCGCGAGGGAGCTCGCCTGGGTGCTGTCGGAGGAGGGGTGGGAGGACCACCTGGGGAGGGACGGCAGGATCCACCATCGCACGAAGTCCGTGACCGGGGACTTCGAGTACAGGGTGTCGAGGGAGGGCGGCGGGAAGGGGACTGTCGAGCTGCGGGAGCGGAGGGTCGTCACCTTCAGCCCCAGGCTCCGCTCCAAGCAGCTCCGCGAGATCAACCGGCAGGTGGAGAAGGCGAGGAGGCTCAGGCTCGCGGAGGCGAGGAGGTCAGAGTACGGCGACAGCGCCAAGTACGTCACGTTCGTGGCCGTCGACTCCGAGGGCGAGGTCAGGGACGACGAGCGCGTCGTCGCCACGCTCAACCGCAAGGCCATAGGGAGGGCCCGCTCGCTCGCCGGCTACAACATGCTGGTCACGAGCGAGGCCGACATGCCCGAGGCCGAGGTGTACGACACCTACCACCGCCTGTGGCGGATCGAGGAGACGTTCCGGGTCATGAAGTCCGAGCTCGACGCGCGACCCGTCTACCTGCGGAGGCACGACTCGATAGTCGGGCACTTCCTCATCTGCTACGTCGCCGTGCTGCTCGTCCGCCTGCTGCAGGTGCACGTGCTCGGAGACGAGTTCGGCTCCGGACAGCTCTTCGGCTTCATGCGCGGGTTCAGGGCGGTGAGGGTGTCGGAGCGCAGGTACGTCAACATCTCGCGGTCCTCGCCCGTCATCGACAGGCTCAAGGAGGTCACGGGGCTCCCCCTTGACCACTACCACCTCACGAAGGGTGAGTACGACAGGATCCTCGGATACAGGTTCCCCTCCCTCAAGGCCACAGGCCAGGAGGAGTCGAAAGGGTCGATTTAGCACTAGAAATCAAGGTTGTACGCCAAAGTCAGGTACCATACACCAAGGACTCAATGCCCACCCCCTTAACGCCAGTAACATTCGACACGTCTTTGACTTGCCTGACGAGGCTGATGTCACGTTCGGTATAGAGACTCTGATACGTATAGTTGAGGGGATTTGCCCCACTACCAAATGCGATCGTGAGGACGTTTGCATCCGAGACTTTCATCTCATCCAACATTTTCGCATAGAATGACTCGGACAGCGCGAGTACTGACGAGATGAGGAGCACTGATATCCCAACCGCAAGTATAGTCAGCCTATTACGTCTTCCGTTGATTTGGTAGTCCCTGCGAGCGAGAAGGAGCAGGCCTGTCTTCATCTGATTTGTCACCCATCCTGACTGCATAAGCGGCTAGACAAGAAAGTCATCAAGAGAAACCTGGCGAACGTCTCCCTCAATGATTGAGAAAAGCATATCAGCACCCTCGGCCACGGCATGACTATGGGTAACAGAGATGATGGTAATGCCCATCTCATCGTTAATGCGTCTAAAGAGTTCGATGACCCTGCGTTCGTTGTTAAGATCAAGGTTACCGGTAGGCTCGTCTGCCAGGAGAACGGTGGGGTTATTGATAAGGGCACGTGCTATAGCAACGCGCTGCTTCTCGCCCCCGCTGATAGTTGAGACATTTTGCCCCAATATAGACTTTGGCAGATCAAGGATCTTCAGCAGATGGTCAAGCCCCATCATGCCAGTATCATGCTGACTGAAGAACCGTGGGAGCAAGATATTCTCCTCGACCGTCAACGCGTTGACGAGATTAAACGTCTGAAATACATAGCCTATGGTGCTGCGCCTGAGATCCCGAATAACAGAAGGACTCGCAGACACAACATCAGTCCCATCGACTAGGATTGACCCGTTGTCGACCGATTCGACACCAAAAATGAGTTTCAGGATTGTCGACTTGCCCAACCCAGATCTGCCAACAATACTTGAAATCTTTCCTTGGGGAAACGTGACCGAGGCATCGCGCAGGATAACATGCTTGTAGGCGCCGTCCGAAAACGATTTTGACACATTGACGAGCTCAATCATTGCGAGAGCCTCCACTAGACGATATGACCCGAATCGAGGAAGTGGAACCTGTTCCGGGTTGGGGTCCCAAGGGGGACCTCCTGTGAACCGGAATGGTTCCGTCGCGACAGGACGATACCGAGGCGCCACAACCGGCAGGAGGGTTCCCATGGCTATCTATTGTACATACTTCGAAACCGGCGGCTATCTGCGAACCACGACGATATGCACACTGACGCCAGAGGTCGGCGAGCTGTCTTGTTCAATAGGAACTGCGCAGAAGGGACTGCGGTGGGAATAGTATGTACTTCCGAAGTCAGGGGGCGTAGGGCTGCGACCCTACGGAACGAACGTTACAGTTTGTATGATACTCTCATGTAGAGATACTATGCTTTACGTAGGGGCGTACGTCTACGACCTGCCGGGCACCGGCTGCCAGATATGGGTCAAGATCTACTATAAAATCACCGCAGACCTCAACGACCCCATAGTCGCAAAGCTGTCGGACGGCGGCGTTGACATACTCCCGCCGGGTGGAGGGTGAGGCCGTATGCCCAAGGACTACGTGGCCGCGTACGAGAGGATCGCGCGCGAGGAGCACCGCGAGCATGGCTTGGTCGAGCTCGGGGGGTGGGACACGGAGCCGGTCGAGGCGCTCGTGGCCGAGATAGGGGCGGACCCCGCGCTCGTGGAGGACCGCGAGGCCTGCCGCGCCCGCGTACGGGCGCTCCGCGACCTGTACCACGGGGACCGGGCGTTCCCGAGCGACTGCCCCTCGGGCCGCAGGCTGGCCGAGGCGGCGCGCTCCTACCTCGGGCGCTGGCCCTACGACAGGGAGGTGCAGGACGCCTACTTCGAGGCCATGGTTCTCTCGTGGCGCTACGGCGAGGCCTACGACTACTACAGGGAGCTCAGGAAGGACCCGCGCGCGAGGCTCTACGCCGTCTGGCGCATGTCGGACCTCGCCAGCTCCCTCTATCACGAGGGCTTTATCGGCGCGCGGGAGCGCGAGAGGCTCTGGGCTGCCGCGCGCAGGCACGACATCAACACGAGGGGGGACTGGCTGCCGCCCGACGTGCCGCCGTACGGGTGAGCGCGCACGCGTGCAGGGGGCCGACACCCCGCCTCGATGCGGATACGCCTAGCGACAGGCTCGGACACCGCCTCGCGCGCCGTTGCCGTTTTCGGTTATCCGCACGAGACCCCTGCGCGTTGCCGATCCGGGCATACCCAAAGAGACGCCCGACAGGCGGGCGTAGGCCATGACAGCTGACCGAGCCGGGCGCGCCAGGGCAGAGGGGATGCGAGAACCCCCGCAAGGAGGCCGGGCGCCTAGCCTGAGCCCCGCCGTGGGCCGAGGCGGAACGGACGTGTCCGCCTTCCGGCGCGTCCGGGGCGTTCGCACGACACGCTCAATTATCGCCTCCGTAAGTTTGTCGTCACCCAGGGCCGTGCCCCACTCCCCGGGCTCGATATCGCCCATGATGGCCAGCTCCCTCCTCTCGTGGCGATCCAAAGGTATGGACGACGAGGTGCTCCTGGCTGAGAGGCGCACGCTATGGCGCAGTTGGTGAAAGAAGGGTTCGAGAGGCTGCACGGACCTTTGCTCTGCGATTGCCACCAGGGAAGGCAGCTATCGATCCTTTTCGTCGGGCGAGGCGTATACTTAGGAAGGTACAGAGTAAACCAGTCTGGCCAGCCGCAGAGTCTCTTCGGCCTACGGAGATATACGTTTACGACTTGTTGAAAGCCGTTTGTTCTGCGTCTCCTTAAATGCAACCCTCTTGGATGGGCTTAGTAAACGGAAGGAGGAAGCTTGATTCCAGAACTGCAGGAAATCGGCGCGCTTCGCAAAGTTCTTCCGTATGGCAGGTACCTGACGACCATGGATGAGCTTGGGGAAACATACGCGCCGACAGACAATGCCGTCCGTCGAATGATTTGGGATGCGTTTCAAGAGGTCACCGCAGTTGTGCGGCAGGCATATGGCAAGTTGGCCGCAACATGGATCGGCGGAAGCTTCATAACTTCCGAAGAGGAGCCGCATGACATTGACGTAGTCTATCTCGTAGACGAGAGCAGCTACAGCAACGGCATCTCAGATCCACGCAGTCAATTTGTGACTCAGGTGCTTCTCAGGAGAAGCCCCATTACAGACAAGCTCAACCCTTTGGTTGATGCCTATTTGTTCCCAGTGCCGCCTACGACCATTGACAACAATTATAACTATTCGGCAGCGAGGGGGTATTGGGACCAATTCTGGTCTAAGACCCGTTATGAAGAGGGGAACTGCCGATGGCTCTACCCATCGGCAGGGTATCTGGAGGTGATGATCGATGGCTACGAGAACTAAGCTGGATGACTATCTGGCGCTACTGGGTTTTGACCCAGAGGCCACCTATGATGTCCCAGAGAACCCGGCAGATGCCGCTCTTTCTGGCGTCGCTGCCTTCGTACGCAAGCACAGCGCGGGGCAGGAGCCAGAATCGACGGGCATCATACACATCACCGGACCCTCCGCCCTCGGCAATTCGGCACCAGTTAAGGCCGTTGGCAACCTGTTGACATCCATCCAGAGCACCATTGACGCCGTAGGCGCATCTCTTATGGGAAATAGGTCTGCGGAGGGCTCGCTTCCCTCGGCCATCACGAGCCGCACAGAGATGTCGCTGATAGCCAGTCCTATGCCTGGCTCGGTTGTCATACAAGTCGCCCCCTCCTTAGCACGCATGGATGACCTCTACCCAGAGGGCCTTGGCCTCTTCGACGTGGAGGCGGAACTTGATGCCAAACCCCTTGCGGACCAAGCGTTCATCGAGTTCTCAACGCTTATTAGCGAACTGAGAGAAGATGACCCCGACAATTCCCAGTTCGTCGATCACCTGACCGACCTTGGCCCGCGCGTCGCCACCGCCATGAAGAGCTTCTGCGAATCCGTCGATAAAGGTGTTCTTGACCTGGAGCTCGAATGGACTGAGTCCAGTAGAAAGGCTAAGACTGCGAGCATATCGCACAGTCATGCTGAGCGTGCCGCAAAGCTTATCGCGAGTGCGAATATCGAAAACGAAGAGGTGGCCATCGAGGGCGTACTTTTGACCGTCACGCAATCTACCAAGGACAAACTGCGTATCCTGGAAGACGACGGTCAAGAAGCTGTCGTGATGATCGGTGACATACCTCCTGCTGCGACGTATCCGCTCCATACGGGAGAGAGGGTGCGGATACGTGCCGAGAAACGTGTGAGCCGAAAGCTTGGCGGCACGCGTAGCGAAAAGCTTGTTGGCAAAGCAGTTGAGCTTGCGACAAAGCTCGAAGCTTAGCTCACACTCATTCACTCGTGCGACAGTCCTCCAAGCGGTTCACAGTGTTAGCCTGGATTCCCGCATCCTACGGTGTGACCCAACTCTCAATGTTAGCGAGCAATTTCAAGGCGATGACATAATGATACTCGAGTATGCTTACGACCTGCCGGGCACCGGCTGCCGGGTATGGGTCAAGATCTACTACTGGATCACTGCGGATCTCAGCGACCCCATACGCGCAAAGCTGTCGGACGGCGGCGTTGACATACTCCCGCCGGGGTGAGGGTGAGGCCGTATGCCCAAGGACTACGTGGCCACGTACGAGAGGATCGCGCGAAAGGAGCACCGCGAGCATGGCGCGGCCATACATGGGGGGTGGGACACGGAGCCGGTCGAGGCGCTCGTGGCCGAGATAGAGGCGGACCCCGCGCTCGTGGAGGACCGCGAGGCCTGCCGCGCCCGCATAAGGGCGCTCCGCGACCTGTACCACGGGGACCGGGCGTTCCCGAGCGACTGCCCCTCGGGCCGCAGGCTGGCCGCAGCGGCGCGCTCCTACCTCGGGCGCTGGCCCTACGACAGGGAGGTGCAGGACATCCACTACCTGGCCATGACCCTCTCGTGGCGCTACGGTGAGGCCTACGACTACTACAGGGAGCTCAGGAAGGACCCGCGCGCGAGGCTCTACGCCGTCTGGCGCATGTCGGACCTCGCTAGCTCCCTCTATCACGAGGGTCTCATCGGCGCGCGGGAGCGCGAGAGGCTCTACGCCGCCGCGCGCAGGCACGGCATCAACACGAGGGGGGACTGGCTGCCGCCCGACGTGCCACCGTACGGGTGAGCTTGTGGGGCCGATGTCCTGCCCCTGCCCAGCGCGGTCGCTAGCCGCCCGCTCGCAGCTCCTGCGCGAGGTAGCGGCCCGTGACGCTCCTGGGCTCGGCCGCCACATCCTCGGGCGTGCCCGCGCACACGATGTGCCCGCCCTCCTCGCCGCCTCCAGGTCCCATGTCCACCACCCAGTCAGCGTTCGCTATCATGTCCAGGTCGTGCTCGATCACGATGACCGTCGCCCCGCTCCCGATGAGTCCCTGCAGCACGCGCAGGAGCGTCTCCACGTCGAGCGGGTGCAGACCGATGGTCGGCTCGTCGAAGACAAAGAGCGCGCCGTCCTGGTGCCTGCCGATCTCGCTCGCGAGCTTGAGGCGCTGCGCCTCTCCCCCGGAGAGCGCGGGCGTGGCCTCTCCCAGGGTCAGGTACCCAAGACCCAGCTCGCAGAGCACCCTGAGGCGTGAGGCGACCCTCCTCAGCCCCGAGAGCCTCTCCAATGCCTGGCTCACCGTGCAGGCCATGAGCTCAGGGAGGGAGACGAGGCCCTCGCTCTCGCCGCTCACTCCATGACGTGCGGGCATCTTGATCTCCCACGCCTGAGAGGCGTAGCGCGATCCCTCGCAGTCGGGACAGGGTATGTCCACATCAGGCAGGAACTGCACGTCAAGTGATATCTGTCCCGTGCCGCCACAGGTAGGGCAGCGGAGCGTGCCCGTGTTGTAGCTGAAGTCGCCTGCGCGAAGCCCCAGCCGCTCGGCGTCAGGCGTCTTCGCGAAGCTGCGGCGCAGCTCGTCGAGGACGCCTGAGTAGGTGGCCAGCGTGGAGCGCACGTTCACGCCAATGGGCGTGGCATCGATGAGGTTCACGCGTCGCATGCCCGGCGCCGCGACGCTCACCACGTGCTCGGGCAGCCCCTCACCTGCCAGCTGGGCTCGCAGGGCAGGTATCAGGCTCTCGAGCACCATCGTCGTCTTGCCCGAGCCCGAGACACCGGTCACCGCCGTGAGTTTGCCTTTTGGGATGCGCAGCGTAAGTGGCCTCACGGTATGGATGCTCCTGGTGACAAGCTCGATCGCCCCCTGCTCGAACACAGCCTCGCGCACCGTCGCCCCTGATCCCGCGCCTGCGCGCTCACGCATCCGCACCCGCCGCTCGCCCGTCAAGAAGGGGGCGATGCGAGAGGCCGGGTCGCCCCCTACCTCGGCGACACGACCCTGGGCGATGATGGTCCCGCCGTCGGCACCGGACGCCGGCCCCACCTCGATCAGGTAGTCTGCCCGCCCAAGGACGCGCACGTCGTGGTCAACGACGACGACCGTGTTGCCATCTGCGAGCAGGTCGTCTACCACCTTGAGAAGGCCGTCCACGTTCGATGGGTGAAGGCCTATCGAGGGCTCATCAAGCACGTAGAGCACGCCCGTCGTCCGGTTGCGCACCGCTCGGGAGAGCTGGACGCGCTGTAGCTCTCCCGTCGAGAGGGTCGAGCTCGCGCGGTCGAGCGAGAGGTACCCCAGCCCCAGCTGCTGAAGGCGGAGCAGGGGCTCGCGCAGCCCGTCCACGATGGCCTCTGCCATGGGCCGAAGCTCCACGGGAAGCGACCCCGGCACGTCGGCCACCCACTTCGCGAGCCCATCGAGCGTGAGCGCCGAGACCTCGGCGAGGGTTACACCCCGGATAGTGACGGAGCGCGCCCGCCCGTTGAGACGCGTGCCCGCACAGTCCTCGCAGGGACCCACCTTGAGGTACCTCTCGACGCGCCTCATGCCCTTCTCGTCCTTGACCTTGGAAAGCGCGTTCTCGACGGTGCGGACGGCGTTGTAGTAGGTGAAGTCAAGCTCGGCGAAGGTCTCACTCTTCTTCGCGCGATAGAGGATATGCCGCTTCTCGGCGGGGCCGTGAAAGACGATGTCGCGCTCCTCGGGCGTGAGCTTTGAGAAGGGCACGTCGGTCCGCACGCCCATCGCCTTGCACACCTGCTTCATGAGGTCCCACATGAGGTTGCCCCAAGGCGCCACCGCGCCCTCGTCTATGGTGAGGGACTCGTCCGGCACGAGCTTCGACTCGTCCACGACGCGCGTGACGCCTGTACCCCCACAGCTGGGGCAGGCCCCCTCGGAGTTGAAGGCGAGCTGCTCGGCTCCCAAACCCATGAACTCGACGTTGCAGCGGGGGCACACGAGCGGTCGCTCGAGCGCGACAGCCATGCTGGGCGGGACCTCGTGCCAGTTAGGACAGCGATAGGTCCCCACGCGCGAGAAGAGCAGGCGCAGGTGGTTGAGAAGCTCCGTTGCGGTGCCGAAGGTAGACCGCACGCCCGGGACCGTCGGACGCTGACGTAGGGCGAGCGCCGCAGGCACGTGCAGCACCTCGTCCACCCGTGCCCTCGAGGCCTGCGACAGGCGGCGACGCGTGTAGGTGGAGAGTGCGTCCATATAGCGGCGCGACCCCTCCGCATAGAGCACACCCAGCGCAAGCGAACTCTTGCCCGAACCCGATACGCCGGCGATGCCCACGAACTGCCCCAGCGGCACGTCCACGTCGACACCCTTGAGGTTGTGGACGCGAGCACCACGCACCTTGATATGGGTGGGCGGACGGTGGACGTGGGTCATGTCTCTCCTCCTCTGCGAGCGATCGCTCCTCTGCCTGATGCCTCAGGGCAGCTTCTACCCGTTTTATTCGAGTGTCCGTTGCGAAGCGAGGCGAACAAGGCGAAAATAGGCGAACAAGGCGAAAATAGGCGAACAAGGCGAAGGGAGCTGACCTACCCATGGCAGAGAGAAACCCATTTACGCCCGCCTTCGGCACCGTCCCACCCATTATGGCAGGTCGAGACCGACTCCTCGCAGAGCTTCATGCCGCCCTCGAGCAGGGGGTCGGCGACCCCAACCTCTCGAGCATCCTCGTCGGCGCCCGAGGTACCGGCAAGACGGCCTGCCTCACGCGCCTCTGTGAGGATGCTAGCGACGCGGGCTGGGTGAGCGCCAGCTCCTCCGCCATACCCGGGTTGCTCGATGACATTCTGCAGCAAGCACAGCGTGCGAGCGCGCAACTCGTCAAGCCGAAGCCGCAAAGACAGCTAACGGGGCTGAGCGTTGGCCCTCTTGGTGCGAGCTGGGACATGGGTGACGAAGAGCGAGGTAACTGGCGCACGAGGATGTCTGCGCTGCTGGAGAGGCTCAACGCGCGCGACGTGGGCCTCCTCATCACCGTGGACGAGGTGGACGCCTCGCTCAGCGAGCTCATCACGATGGCCGTGGTCTACCAGCATTTCGTACGGGAGCGCCGCAAGGTCGCTCTTCTCATGGCGGGACTGCCCAGCCACGTGCACGCCCTGCTCAACGACAAGAGCGTCTCCTTCCTGAGAAGGGCGCAGCGACACCCCCTGGGAACCATCGCCGACGCCGACGTGCGCGACGCGCTCAAAAGGACCGTGGCCTCAGGCGGCAAGACCATAGACGAGGAGGCGCTTGAGATCTGCGTCGAGGCGACAGGGGGATTTCCCTACATGCTTCAGCTCGTGGGGTATCGAAGCTGGCAGTCGGCGCTGGGCAAGGCCGAGGTGGGGAAAGAGGATGCGAGAGCGGGGATGCGGGCTGCGCAAGAGGATTTCAAGGAGCACGTCCTGGCATCAACGTATCGAGAGCTGTCTGCGGTGGACCTGCGCTTCGCAAAGGCGATGCTTCCCGACAAGGCCGAGAGCCGTCTCGCTGATATCGCGAGGCGCATGGGCGTAACGAGTCGCTACGCGTCAAAGTACCGAGGTCGCCTCGTGGCGGCCGGTATCGTCGAGGAGCTGTCGCGTGGCGTGCTCAGGTTTGCTATCCCGGGCTTCAGGAAGTACCTGCAAGAGATGGAATAGCCGCGCCCGGCGCGGCGGAGGGGTGCGCCGGCAATTCTCCTCCCCCCATTTTGGGGAGGAGATGTCCGTCTGAGGATAAGACCTCTGCCATGTACGCAAGAGACAGTCTAGCGTGTATAATCGCTACAGGGTGTATATATTCTAGCAAATTTGTGTACATGATGGGCTAATTGAGTACGAGGTGGGACATGCAGGCAGAAGTTCTGAGGATCATCGAGGGTGGTCTGACCGGTAACAAGACCAAAGTCCTCAATTATGCGAACACGCTTGCCGACAACCTTGAGCAGTCAGGAGATGCCCGCTTCGCCAAGAGGATTCGGAGCACCATCGCCGGCAAAAGGTCGAGCATCGCCACGCTCGACGGCCTTGCGGCCAAGCCGGTGGACCAGGAGAGCCGCATGAACATTGTGGATGTGCAGACCATCCTCCCCGATGATGTGGACATCGTGCTCGGCTCCTTTCTCAAGGAGGAGATCGACGGCGTAGTGGCAATGCGCGGCAAACGCGACGTGCTTGCTCGCCATGGTATCGATGCCCAGAACTACCTGCTGCTCTATGGACCTCCCGGCTGCGGCAAGACGAGCATAGCCCGATACGTAGCGGCCCAGACCGGACTGCCGCTCATCACGGCGCGTTTGGATAGCCTCGTCTCATCGCTTCTAGGCAGCACCGCAAAGAACATCCGTAAGGTTTTCGACTACGCGGCCCAGCAGGAGTGCGTTTTCCTTCTTGACGAGTTCGATGTGGTCGCCAAACGTCGTGATGACGAAAACGAGCTGGGGGAACTCAAGCGCGTCGTCAACAGCCTACTGCAAAACATTGACGACTTCGGTCAGGGCAGCATCCTTATCGCAGCCACCAATCACCCGGGCCTCCTAGACCCGGCCGTATGGCGCCGTTTCAACAAGGTGGTTGAGGTACCCACGCCCGGCAGGGCGGAGCTGGAGGAATATGCTGAACGGTTCATCCAGCCCCACATGGCCACGAAGTTCAAGAAGAAGCTCTATAGCGTGCTGGAGGGCCTCAGCTACTCCGCCCTCAGCACAGCGACAAAGAACGCGTTCTACAGCGCTGCGCTGGATGGGAGCGAAAATGGCTTCACGACTTACCAACTGGCCAGAGAAGCCTACACCTTGACGCATCACAGTCTCGACGATCAGGAGGGGTACATCCGCCACCTCATCGAGGCGGGATGCACGCTTAGGGAAATACACGATAAGACTTCCATTTCGATGCGCAAGATTCAGGCAATCTCACGGTCGTTCAAGGAAGGGGTGTAGGCCATGGCAGAGGAATTCCTTCCCATAACGGTCTTCCGCCAGCGGGAGATAGATGAAACGCGCGTCGAGGGCATGGGGAACAAGGACAAGCCGAAATGGGTGCTGTCAGGCGCGGATCTTCACGAACATGCGCAATCGCTCATCGCGGGGCTGAGCGATGCCTATGAGGGCGTGCTCCATAACGAGGGACTTCCCTATGTCTACGACGTAAAGCTGAACGAGAGGGACACATCCAAGACCAAGCGCAAGCCAATCGTTGACATGCTCAACGTCGATGGTGCCAACGGCGAAGCTAATGTCATAGGCATGCGAGGTGCCAACAGCCTCATTGTCAGGGCAAAGGACGCGGGCCAAGTAAGAGCCATGGAAGAGCGCCTATCCGATAAAGAGCGTTACGACCTGCCGCTCACGTGCATCGAGTCCATCAGCCGGTTTGTGCCCGAGATCAAGCCTACTCCGGATGAGACCGTATACAAGGCGCGACTCCTCGACTTCGGGCCGGACGCCGCCCTGTGCGAGCGGGTATTTGAAGACCAGCTCGATTTCCTATGCATCGCATTCCAGAAGGTCAGCTACGCGCAAGACCTAAACGTATATCGGCTTGAGGCCAATCAGTCACAAGTAAAGATGATTGCGGACGGCGTAGCCAGCGAGACGCTCTTCTTCATACGCCCTATGCCACGATGCGTTGCAACGCTCGACGGGATGCCCAGCGTGGGAGCACCCGACCCCATGGAGCCCGACTTGAGCATGGAGTATCCCGTCGTCGGAGTGCTCGACAGCGGGATTGCGCCGATCTGCCAGCTACAACCGTGGCTCATGGAGAAGCGCCTATCGACATACACGGACAATGAACTTGACAAACAGCACGGCACGTTCGTGGCGGGTGTCATCACCTATGGCGACAGGTTCGAGCATTCGGAGTGGGTCGGAGGCCTACCGCCGAAGCTCCTGGACGGTGCCGTGTTCCCAGCAGATGGGAATATCGACGAGTCGACGATGGTTGACTCCATCAGAACCATCGTTGGCGCGACGCGCGATCGTGTGAAGGTATGGAACCTCTCACTGAGCTTCATGGACGAGATCTCAGACAACGAGTTCTCGGAATTCGGCATGGCGCTGGACGCAATCCAAGATGACCACGGCGTCCTCATCTGCAAGTCGGCGGGCAACTGCGATGTGAGGGCGGATAGAACCAAGGGCCGCCTCTGCGTTGGCTCGGACTCAGTGCGCGCACTCACGGTCGGTTCTGCCGCCCAGGTGAAGGCCCCGCTCGATCAAGCAGGAGTTGGCGAGGCCTCGCCCTTCTCGCGCAAGGGCCCAGGTCCCCAGTACATCATCAAGCCCGAGGTGTCGCATTATGGTGGCAACGTGGGAAGGACGCCAACAGGCTACGTCAGGTCGGAGGTCCATTCATTCGACGTCACGGGAAACCCTGCGGGGGCCGTCGGCACGAGCTTCTCAACGCCTCGCGTGTCAGCCTTGGCGGCAAACCTCCAGCTTGCCTTGGCAGGAGAGTTCGACCCACTGCTCATAAAGGCTCTCATCGTACACTCGACGTCATTTCCCGGCGACAGCCTCATTCCCAACACCGAGAAGGTCGAGGAGATGGGGTTCGGCATCCCGGTCAACCTTCGCTCGATACTCTCGGACGAAGAGCATTCGTCGACCCTGGTACTGCACGGATTTCTCCCGAGAGGACAGAAGGTTGAGATCAACGACTTCCCCATGCCAAGCTCGCTGGTTCGTGATGGGTACTACACTGGCCAGGTCATCCTGACTGCCGCATTCTCTCCTATCAGGGAGCCAAAGGAGGCTGCCGAATACTGCCAGTCCGACATCGAGGTGAAGCTCGGTACCTACGACCACAAGGAGCTACGCGATATCACCAAGCAGGGAATACTCAATCCCATCGGTCGCAAGGACAACAAGAATCTGCTGAATCCAAGTCGGTACAGCCGCCCAAAGCTCAGATCGGCCGAGGACGAGTTTTCCCGCCGGGAGAAGATGCTCATCAGGTACAAGGGCAAGTATGCACCGGTAAAGAAATATGCTCTCGACCTGGCCGATCTTACCAAAAAGAACCGTGAGGCCGTTCGCGCCGACCGCCTGTGGTATCTGGACATGAAAGGAACCTACCGCGACAGCGTGGAACGAAGGGCACTCCAGACAAACGAGCCGCTGAGGCAGGAGTACTGCATCATCATCACCATCCGTGACCCAAATGGTCTTGCCCCTGTGTACAACGAGGTGCCGCAGCTCCTCGAGCATAAGAACTTCTGGCACCAGAACGTCCAGCTAGCTAACCAGGTCAGAGCCATGGTTGGACAGTAGGTGGAAAAGCTATGGCTTAGGAGTCTCCTGCCTCCCGAACCCATATTCCCCGATGTGCAGCGTGTTGCAGCTTTCGCTCATGACGCTCTGCGTGGTCACGAGAAACTTATATTGACAACATGTCGTCAGTAACTTAGACTTTCTCCCATGATAGATGGCATAAGATCATTTTCTATCCAAGGAGGCGGCATGATTCTAGAAGAGAGCTACAGACTGAACAACGGCGTTGAGATTCCTAAGCTGGCACTGGGAACGTGGCTCATCGACGACGACAAGGTCGCTGACGCCGTGCGCAGCGCGGTCGAGATCGGCTACCGCCACGTGGACAGCGCCCAGGCCTACGGCAACGAGCGCGGTGTGGGAGAGGGCGTGCGCAACTGTGGTGTTCCCCGCGAGCAGCTCTTCGTGACCTCAAAGGTGGCAGCGGAGCACAAGACCTACAGCGCTGCGGCCGCCTCGATCGACAAGACGCTACGAGTGACGGGGCTCGACTACCTGGACATGATGATCATCCACTCCCCACAGCCGTGGGTCGAGGTCAACCAATCCGATGACCGCCACGAGGCGGGCAACGTCGAGGCCTACCGCGCGCTGGAGGACGCCCTGGCCGCCGGCAAGCTGCGCGCCATCGGCGTGTCCAACTTCTTGGAGGGCGATCTGCAGAACATCCTGAACCATTGCGAGGTGAAGCCTGCGGTCGACCAGCTGCTCGCGCATATCGGCAACACCCCCTTCGAGCTTGCCGCGTTCTGCGAGAACAACGACATCCTCGTGGAGGCCTACTCGCCCATCGCCCATGGCGAGGCGGACAAGATCGGTGCTATAGTCAAGATGGCGGAACGCTACGACGTGTCCGTGGCGCAGCTGTGCATCCGCTATGTGCTGCAGCTTGGCATGGTCGCCCTGCCCAAGACGGCCAACCTTGAGCACATGAGGTCCAATGCGGACGTCGACTTCGAGATCAGCGCACAGGACATGGAAACACTGAGGGGCGTCGAGCGCATCAGCGACTATGGGGACAGCTCGTTCTTCCCCGTGTTCGGCGGCAAGCTGTAGGCGCCGCGCCGCGATGCCTCCTTGGCAATGCAGACCATCAGACGTTAGGAAAGCACTATGAGCAACATCCTTGTCGCATACTTCTCTGCAACCGGCACCACCAAGCGCGCCGCAAAGGGCCTGGCAGAGGCACTGGGTGCGGATACCTTCGAGATTGTGCCGCAGACGCCCTACACGAGCACCGACCTCAACTGGAATGACAGCACAAGCCGCAGCACCAGCGAGATGAACGACGAAGCGAGCCGACCGCCCATCTCGGGAACGGTGGATGGCATGGCCTCCTATAACGCCGTGTTCGTGGGCTTCCCCATATGGTGGTACACAGAGCCCCGTATCATCGACACGTTTTTGGAGTCGTATGACTTCTCGGGAAAGACCATCGTCCCGTTTGCGACAAGCGGCGGCAGCGGCCTTGGCAAGGCGCCCGAACGCATGCAGCGCATCGCCACGGGCTCCACCGTTGCGGCCGGCAGGCTGCTCAACGGCCACCAGAACCCCAATGAGCTACGTGATTGGGCGCAGCGCCTGGGCCTCATGCGGTAACGGGAGGTAGGCCATGCCACGCATCTCCGAAAAGGAGTCGAACGCCCGCCGCACCGAGATCATCGACGCCTGCGAGGCGCTCTACCAGCACACCAGCTATCGCGACATCACGATGGCGCAGATAGCAGGCAAGCTCAGCTTCAGCCGTGCCAACACCTATAACTACTTCCAGTGCAAGGACGAGATCTTCTTGGCGCTGCTGCAGCGCGAGTACGAGCGCTGGACGGCCGATCTCAAAGCGCTTGGAGGCTTAGGAGAGTCGCTCGACGACAGGGCGCTTGCCGACGGGCTGGCGAGAAGCCTCAAGAAGCGTCCTCAGCTCCTGAAGCTCATGACCATGAACCTTTACGATATGGAGGAGAACAGCCGACTCGAGAAACTGGCGGAGTTCAAGGGCGTGTACGGACGTGCGGTCGAGGCGATCCGAAGCCTGCTCGTCAAGCTCAAGGGCAACTGGGACAGCGAACGGATGGATCGCTTTGTCTTCTCGTTCTTGCCGTTCGTGTACGGCATCTACCCCTATGTCTTTACCTCTAAGAAACAAGAGGCAGCCATGAGGGCCGCAGGCATGCATCCGAAGCGCCTCGGCATCTACGAGTTGAGCTACCCGTTCATCCTGAAGATGCTTGAGGATGACACGAGAGGCCAGGGCGTGACGCGGGCGGGCGTGACGCGCAAAAGCGACGAGGGAGGCGCCATGAGCGAGCTCGAGAAGCTGGAGGCCGGTTTGGAATATAGCTTCGAGGATGCTGGGGTGGCCGCGCGCAAGGCAGAGGGCGTCGCTGCCTGCACCAGGCTTGCGGCCGCCGACCAGAGTGACGCTGTGGGCTATGAGGCGACGGCGCGATCCATACTTGCCGAGGCGGGTCCCGGCCTCGATATACAGCCTGGGTTTCGCTGCGACTGAAGCAAGAACATCCATGTGGGCGACAACTTTACCGCCAACTACAACGTAACCATACTCGACATCGCACCCGTCACCATCGGTGACGGGTGCATGTTTGGCCCGGGAGTGACCATCTCGGCCGTCACGCACCCCGTCAATGCAACAAGGTGTCGGGACCGCATAGCCCAGGCGAAGCCCGTCACCATAGGCAATGACGTGTGGCTGGGGGCAAACGTCCTGGTCATGCCAGGGGTAACCATAGGCGACAACGTGGTTGTGGGCGCAGGCGCGGTAGTCACGCACGACATCCCCTCAAACAGCCTCGCCATGGGCGTCCCCGCACGCGTGGCCAGACGGCTCGACCACCGCGAGCGCGAGGCCACGAAGTAACGACGGAGGACAGCACGCAGAAAGGAAGCGCATCATGATCAACTTCAAGATGAACAACGGCAACACGATACCCGCCCTTGGCTACGGGGTCTTCCAGATGACGGGAGAAGAGGTAAGGCAGCACCTGCCCGAGGCCATCGAGCTGGGCTTTCGCCACATCGACACCGCAAACGCCTACTTCAACGAGGTTGCTGTCGGTGAGGTTGTAAAGGCAAGCGACATCGCGCGCGACGAGTTCTTTGTGACCACGAAGCTGTTCCCACAGGACTACCCGTACGACAAGTGTAGGAGGGCCATCGACGAGACCCTCGCGCGTCTTGGCATGGACTACGTCGACCTGCTGCTGTTCCATCAGCCCTACGGCGAGTACGTAGACGGCTGGAAGGCCATGGAGGAGGCGGTACGTGCGGGCAAGGTCCGCGCGATCGGGCTCTCCAACTTCAGCGAACAGAAGGTCCGCCAGATCCTGGGTGTGTCCACCATCAAACCCTCCATCCTGCAGGTCGAGATCAACCCCCGTTGGAACCAGCACCCCCTCAAGGAGGCGCTTGCCGCCGAGAACCTCGTGTACGAGGGCTGGTATCCCTTGGGACACGGCGACAAGGAGCTGCTGAGCCTCCCTGTCTTCACCACGCTGGCCGAGAAGTACGGAAAGTCCGCCTCGCAGGTCATCCTGCGCTGGCACATACAGGAGGGCAACGTCGTCTTTCCCAAGACGCTGAACCCCCAGCACATGGCCGAGAACATCGACCTCTTTGACTTCGCGCTGACCGACAAGGAGATGACAGAGATCAACGCCCTGCCGCAGGAGCCGTACTACCACGTGCCCGACGAGGCACCGGCGTGGGTATGGGGCCCGAACGACTACAGCAAGCAGCGCTAGGACGATCGGTGGCAAGGCACCTCTCGGCTGAGGAAGGTACCCCGCAGATTCTGGGGCACCTTGAAGAGGATCCCAACTGGGCAAACGTCCCTGAGAAGGTACCCCATAGATTTTGGGGCACCGAGATCGTCCTTCATGGTTGGCGAGAGGACAGCCACTGTTCGTGGGAGGGTCTCAGCCAGAGAGGCGAGAGAGGTCGGGTGGGGGAATGACGAGGGAGCGCTCCGACAGGCCGAGCCGCCCCAGTTCCTCGCGGGCTCCGATGTCTTCCGCCACGAGCATCCGCGCCAGGAAGGGCACGAGGTAGAGAGGGATGTAGTGCATGGGCTTTCCCGCGCGAAGCTCGGTGGAGACGTTGGCCTCGGAGACTACGAATGCTTTCTCGATGCCGAACTCCTCGACTGAGAGCAGGTTGTTTAGGGCGACGTGGCGCTTATAGGTCTTGCCGGACTTCACCTCGATGGGCAGCACCTTGCCCTGCAACGTCTCCCCGATGAAGTCGACCTCTCCCCTACCGCTGTGCCGGTGGTAGCGTAGGGCGACCCCTGCCGAGGCAAGCTCCTGTGCCACGACGTTCTCGTAGATGCCGCCGCAGTTTACGTCCCGCTCCCCCGCAATAACGGCAAGGGAGACGGGCACAGGGTAGCGGCGCATAAGCATACCCGTATCAGAGAGGTAGAGTTTGAAGCGATTGGGCTCCTCGGTGCGCCGAAGCATACTGCGCGGTTCGGTAACGTTCACGGTCTTAAGCGCCGCTCGTGCGGAGACGAGCCACTGGAAATCATTGGCGTATCGCTCGTAGGTGGCCTTCTTGCGCAGCGACCGTAGCTTGAAGCGCTTGTTCTCCTTGTCGAGCTGGCTGGGGATGTCGTCGTAGATGGACGTGACCTGCAAGGCCCGCTCCCCCGCGTAACGAGATATGTCCGCGCGATAGAGCTCGATGAGGTCCCTCTGCGTATCCCGCACCGCACCGAGGTCATTGCGTGAATCGATATAGCGCTGGACGGAGGCGGGCATGCCTCCCACCACCACGTAGAGATGGAAGAGCTGGAGGAGTTGATCGTGCAACGATTCCTCGACGGGGGAGAGGCTCGTGAAATGCCGCTCGAGCCGGGTGATAAGCGAATCGGTCGCCCCCTGCGACCAGAGGAACTCCTCAAAATCGAGGGGATACATCGTCTCGATCCTCAGGGAACCCACGGGGAACGAGCGCACACGGCGAAGCTCGACTCCCAGTAGCGATCCCGACATCACAAGTCGGAACCGTCCGTCCTGCACAAGGTATTTCGAGAGCGTGACGAGGTTTTGCGCCTCCTGCACCTCATCGAAGAAGACAAGGGTCTTTCCTGACACAATCTCGTGGCCCACCATCAGGGACAAACGCTCCACCAAGGAACGGACGTCCTGTGCCCCAGAGATAGAACCGGCCTGCGCATCCCTAAGGAAGTCCACTTTCACATAGTCAGCAAACTCCTGCCGAGCGAACTGCTCGATGAGGAAGGTCTTTCCCACCTGGCGCGCCCCATCAACCAGAAGCGCCTTCTCAGGTGCCTCGGCCTTCCAGGAGAGGAGCTTCTCATAGGCTCTTCTTTTAAGCATATATACCTCGTATTTGTTTCTAACATAACCGATTCTGGCCTGCAATTATAGTTCAACTCAACTACCTCACGACCTCTGTACCCTCCCCGATGCAATCCCCTGCCCCCAAAGAAGAGTCATATTCCAGGCGAAGGCCACCTCCTGGTCAGAGTGCGTCTTTCCGTGAGGGCGCCGACTCAGAGTGCGCTTTTACGTGAGGCGGTGCCGCGTTTGCGCAGGTGAGAAAAAGCGCACTTTACGGAAAAGCGCATTCTGTGAGGCCGGGCTCACGGAAAAGCGCAGTCTGGCTCCTGCGGCTCACGGAAAGCGCAGTCTGGCCATTTACAGGAGGCCCGATAAGCTGGGGATAACCGCGTTGCCCTGAGTCTCGTTACTGTGAACATCAAAAAATACACTGGCTTTGCGATCGAGAAGGGGGCAGAATCCCTTTGAGAGCAGGACGGGAGCAGGAAGCGAGGCAGAAGCAGGAGGGGGCGTCCCATGGGGATGTCCGACTTCCTTGAGAGGAGCCTTTCACGATGAACACGCTTGCCCGGGGCATGGCCCTTGCGGGCGCCCTGTCGGCTGCGCTGGCGCGTGAGCTCAGGGCAAGGACATCCAAGCAACGAGGCGGCGAAGCCGGAGAGGCCCTACGTCGTGTCTCGACCACATACCACGAGAACGAGTTTTGGGTAAACGTGGACGGACAGAACGTCTACGGGCTGTCCTATGTCCCCGACGTCGGAGGCAGGTTGCCCCTCGTCATCCTCTCGCACGGCCTGGGTTCCGACCATGCGATCGCGGGGCCTTACGCACGGGAGCTCGCATCGCATGGGATCGTCACGATGACCTTCGACTTCAGAGGAGGCGCCGAGACAAACAGGAGCGACGGCACGCCTCGGGACATGTCAGTCATGACCGAAGCCCACGACCTGGAGGCCGTCCTCGCTATGGCACGCGGCTGGGACTGCGTAGACGAAGGGCGCATCGTGATCATGGGGGGTAGCCAAGGCGGTGCCGTGACCAGCATCGTAGCCGAGCGCGCGCAACCCCAGGTGGCTGGCGTGGTCCTCCTGTACCCGGCGTTTTCCATCTTTGACCACGTGCACCGAGCCTGCAGCTCCCTCGACGAAGTACCCGAGAGCAACGACCTCCTCGGCTGGCTGACGGTCGGCTCCCGCTATGCGACGGACGTATGGGACTATGACTTCTACCAGCATATGAGCTATGAGGGGCCCGTTCTCATCATTCACGGCAGCGATGACAGCGTGATACCCATCTCGTACAGCAGGCGCGCCGCCCGAACCTACCGCAACTGCGAGTACCACACCATCAGGCACGGCACACATGGGTTTTCCGGCCCTGCATACGATGAGGCGATGTCCTACCTGCTTGACTTCGTGGCACGCGTGTGCGCGTAGGGCCAACGCGATCCCTCGGCAGCCCTTTGCCCCCTATGTCCAGACCTCCCCATCCGTGCGCCAGCCGATGAACGCCCACACCACGGGTAGCGAATAGTCCAGACGCCAGCCCTCGCTCGCCTCGCCCCCGGCACCCACGTGCCACACACGCTCGAGGTGCTCGGCCGCAAACGCGTCGAGCAGCGTCCGCTCCCGCCCGTCAAGAGGCTCGGAAACCACCATCTTCCGCAGCTCTGCCAGCCCATCGTCCAGCGTGGCAAAAGTCATGGGGCGAAGCGTGGGCAGGTACGCCACCACGGGAAGCCGCCCCAAGTCGCACAGGATGCCCACGGCGTCCGAGACCCTCTCTGGGCGCTCGTCGACCTCACGACCCAGCAGCGCAAGCAGCCTGGGGTCGCGCGAGGGCGTCACGCCAGCCGAGACGGTGATCGCTGCCTTGTGCCTAGCAACGCCATCCAGCCTCCGAAGGCGCTCCCGCATGCTCCTGGACCCGAGCGAGCGCGACGCGATGGCCGCGTCAACGCAGTTCTCTCCCAAGCCCTCCGCAGCCCAATCGTCTTCCCAGGCCAAAAGATGCGCCGTCACGGGCAGTCCTTCGTCAGCAACGACCCTGCCTAGGACCTTCAGCATCCTTTCGGCAAAGTCACAGGCATGTACCGCGTGGCCCCGCCGGCCGAGCGGCACGGCGAGGGTGCCGGTCGCACAGCCCATGTCAAGCACCGTCTGTCCCGGCTCAAGCGCCAGCAGCCCAAGGAGGCGACTCTCATAGGTCCCGTCCGACCCTTGCGCAAACGTGGCGGCGCGCTTGTTCCAGTAGTCCCTGCCATCCAGAACCGACCCCTCCGCAACCGTCGCCCCCACCCCCCATTGTTGTCCCCACACTGGTGTCATCCGCTGCCTCGCTACCCCAGTATAAGCGCGGACGTATGGATTCGACACGATTGCTGTAGGCATGGCTCTTATGCCGAGGGCATATGATATATCTTTGGTGCTGTAGGCTGCGCTCGGATGCGGGAACGGTGAGTTCGATGGGCATCACGTCTGGGAACAGGGAGCGGGGCTTCGGCCCGCCGCCTTGGCGGACCTTCCTTTCCGTGCGTCGCACCCTGCGGGAGAAATAGGAGTAGAGCATGACGCGCGCCAACGTACAGGCAGCCACTGACGTAGAGCAGCAGGCCGACATGGCTGTCGCCCATCAGAAGCTCGAAGACCTCAAAGACTATCTTTGCGAGCTGGGCAGTGTTGCCGTAGCGTTCTCCGGCGGGGTCGACTCGACTTTCCTCATGAAGGTCGCGCAAAACACGCTGGAAGACCATGCCTTAGCCGTCACCGCACGCCTCAAGTCGTTTCCCGAGCGTGAGTGCACAGAGGCGATCGACTTCTGTCACAAGGAGGGCATCCGCCACATCGCGGTCATCTTCGACGAACTCAGCATTCCCGGTTTTAGCGAGAACCCGCCTGAGCGCTGCTATCTCTGCAAGAGAGCGCTCTTTACCCGTCTCATGGAGGACGTGCGCAAGCGGGGCTTCTCCCATCTCTGCGAGGGTTCGAACATGGATGACGAGGGTGACTACCGCCCCGGCCTCAAGGCGGTTGCTGAGCTAGGCGTCAAGAGCCCGCTGCGCCACGCGCAGCTCCACAAGGCCGAGATCCGTGCGCTCAGTCACGAGATGGACCTCCCCACTTGGGACAAGCCGTCCTTCGCCTGCCTCTCGTCGCGCTTCCCCTACGGGGAGGAGATCACGGATGAGAAGCTCGAGATGGTGGGCAAAGCCGAGCGGCTCCTGCTCGATCTGGGCTTTCGGCAGGAGCGCGTGCGGATCCACGGCGGAGGCGACCATAACAGCATCGCCCGCATCGAGGTGCCCCCCTCCTCGCTCCAGCGGCTGCTCGACGAGCGAGAGAGAGTCTCTGAGGCCCTGCGCTCATATGGGTTCGCATATGTCACGATGGACCTCATGGGGTACCGCACGGGATCGATGAACGAGATTCTGTCACAGGACGGGAGGGCATGAGGCAATGGAGCGCGACGAGCTGAGGGCCCTTCTCAGGGCGGTGGCGGCAGGCCAGGTCGATGTGGACGACGCCTGCGCGCGCGTGGGCGAGGCACCTTTCGTCGAGCTGGGCTATGCCAAACCCGACGTGCAGCGTGGCGTACGGCAGGGTGTCTCGGAGGTCATCTACGGCGCCGGCAAGACAGCCGAGCAGATAGCCGGCATCATGGATGCACTTGAGCAGTCGGGGCAGAGGCGCATCATCGTCACGCGCCTCGATGCGAAGAAGGGCGACGAGCTCGAGACGCTCCTCAAAGAGGAGATGCCGAGGCTCGCAGACGGCTACCGCTACCTCGCCACCCCGCGCATGGGCATCCTCGGTGAGGCGCCTAAACCTACGGGCGTAGGCTACGTGTTGGTGATCGCGGCAGGAACGAGCGACCTCTACTGTGCCGAGGAGGCCGCCGTCACGGCTGAGATGCTTGGTAACGAGGTGCGTCGCGTGTACGACGCAGGCGTAGCGGGCATCCACCGGCTGCTCTCGCATACAGGGGACATCCAGCGCGCCTCGGTCATCATAGCCGTGGCTGGCATGGAAGGGGCGCTCGCGAGCGTGGTGGGCGGGCTCGCGTCCTGCCCCGTGATCGCATGCCCGACGAGCGTGGGCTACGGCGCCTCGCTCGGCGGCATCTCGGCACTTCTCTCCATGCTCAACTCTTGCGCGAGCGGTGCCTCCGTCGTAAACATCGACAATGGCTTTGGGGCCGGCTACCAGGCAAGCCTCATCAACCACGTGGGAAGGTAGAACGACCATGGGAAAGACCCTCTATTTGGAGTGCGAGAGTGGCATCAGCGGTGACATGGTGGTGGGGGCCCTGTTGGACCTCGGCGCCAACCAAGAGAGGCTCCTCGCCGCCCTGGAGAGCCTCCCTATGGATGGCTTCTCCGTACAGATCACGCGCAGGGCGGTGAGCGCCATCGACGTCTGCGACTTCGACGTCGTCCTCGACGAGGGGCACCAGAACCACGATCATGACATGGCGTACCTCTATGGCGGCCTAGACGAGGCAGAAAGTCACAGCCATGAGCACCACCACGAACACCATGGGCACGGCGAGGGCCACCACCATCACGCACACCACGAGCACGGTCACGGCGGGGGCCACCACCACGAACACCGTCATCTCAGCGACATCGAGAGGATCATCAACAGCGGTAAACTCACCCCCCGCGCCCGCGAGCTTGCGAAGCGGATTTTCTCGATCTTGGCTGAGGCGGAATCCAAGGCCCACGGCGTAGGCGCAGACGAGGTTCACTTCCATGAGGCGGGTGCCGTCGACTCCATCGTCGACGTTGTGGCAGCCGCCGTCTGCCTTGACGACCTCGATATCACACACGCGATCGTAGGGCCGCTCGCAGAGGGCCACGGACGTGTGCGCACCCAGCACGGCGTTCTGCCCGTGCCCGTGCCTGCCGTCGTGAACATCGCAGCCTCCTGCGGCCTTGTGCTCGCGCAGCGCGCCATGGAGGGCGAGTTCGTGACGCCCACGGGCGCCGCCATCGCCGCCGCCATTCGCACTGCCGAGGAGCTGCCCGCAGCCTACGTCATCAGAGCCGTTGGCACGGGTTCGGGCAAGCGTGCCTACAAGCCCGTGAGCACGCTGCGGGGCATGATCATCGAGCCTCGCGGGACAACAGCGACGGAGTCCCAGCCGGACGCTCACACCACTACGGACGCTGCCCCGAGCCGACTCTGGAAACTGGAGACCGAGGTGGACGACTGCACGGGCGAAGCCTTGGGCCATGCGCTCGAACGCCTCTTTGAGGTCGGCGTGCGCGAGGCTCACTACGTCCCCGTCTTCATGAAGAAGAGTCGCCCGGCCTACCAGGTGGAAGTCCTCTGCGACGAAAGCCTCCTCGAGGCTGTGGAGCGGGTACTCTTCGAGGAGACCACGACCATCGGCGTGAGGCGTCACCGTATCGAGCGCACGACACTTTCCCGCCGCGAACAGACGATGGAAACGCCGCTCGGCCCAGCACGGGTCAAGCTCGTGACCCTGCCCAACGGCAGCGAGCGTCCCTACCCCGAACACGATTCCATAGCCTCGCTTGCCAAGGAAAAAGGCGTCTCCTACCAAGAGGCCTTCCGTACCACCCTACTGATCGCCGAGGAACGGGACGCGAGGTCCTGAGAACTGTGCGTATCTCACGCGCCCCTGATGGGTCGACTCTTACGGGCCCCTTTTCATGAAAGGACCGCATCGGAAGAGCTTCCGATGCGGTCCTAAAGCACGGTATCGATGCCACTGATGACAGAGAGCCGATCGCGCCCGAGCAGGACCCGATGGGACCCGTGCTCAATCGGCCCTCATGTCAGCAAGACTGTAGCGACGGCCTCGCTGACATCTCCAAGCTACGCGCTGCAGGGCTTTACGATAACGGAGATGCCCTCGGGGATCACGGCTATCTTGGCGTTCTCGCCCTTCTCCTTCACAGCGATGTCTAGCGCCTCCTGAAGGGTCGGCACGAAGCGAATGTGCATGTCCTCGAGGATCTGCTTCGCGGATGGATCCGCCACGTACAGTACCTCATGGCGCGAGAGGATACGGGCAAGGATCTGGCTCTCCCACTGGTCAGCGATGGTGTCCTCCATCTTGACCTTCAGGATCATATCCTCGACCTCCTTGGCGGAAGCGGCATTCTTAAAGGTCTGGTAGAAGCCCTCTCCCCCGTGTCCATCGTTGCACTTGGACATCTCTATGATGATGCCGTCCTTGTTGCAGCACGCCTCTGCGGCGGTCATGCTCTTGACGGACTGGTAGATGTTCTGGTCCAGTGGATATCCGCCGTTGGTGGTGATCACGATGTCCGCATCCACACCGTCCACCGAGGAGAGATCCTTCACGAACTTGCAGCCGGTCTCGTGAGCCTCGGTCGGATCTCCCGCAAAGGCGGCGATCACCTTCTTGTCCGCGTCAATCGCGACGTTCAATATGAAGGCAAGCTTTGCCTGCTCGGCAGCAAACAGCATGTCCTTGTGGATCAGGTTGCCATCCAAGACGCCGGTCCGCGACTTGTCGGACGCAATGAAGGTGGAGCAATGGTTCGCAAAGACCGTCTTCTGGGATGCGATGCCCGGAAGGATGGACTTCCTGCCGCCGGAAAAGCCCGCAAAGAAATGGGGCTCGATGAAGCCCTCGGAAACCAAAAGGTCAGCCTCTACGGCGAGCTTGTTGATCAGAAGGCTTCCGCCCGAGGGAAGGGTGCCAAGGTGAACCATGTCCTCGTCCTTCTCGGACTCGTGAATCACGAATTTCTCGTTCTTGACCAGATCCTCGCCGAACTTGTCGATCATCTCTTCCTTGGTCGTGGGCCTGTGGAACCCGGTGGCAATCAGGATCGTGATGTTACAGTCGGGGTTATTTTTCCTAATTTCCTTCAGATAAAGGGGGAGGGTGACCTTGCTGGGGACGGGCCTCGTGTGATCTGACGTGATGATCACGATGTTCTTCTTGCCCTCTGCGAGCTCGCAGACGCGCGCACTCCCGATGGGATGCTCCAAGGCCTCCTGCACCAGCTCCTCCTGGGAACCCTTGGGGACGTACTCCACCGCCTTCGACTCCAAGACCGACGTGGAGTCCGGAAGCGTAAGCTCGACCTTCTCTCTTCCAAATGGGAATTTGACTAGCATGGCTACCTCCTTTTTCGAAGCACCGCCTGAAACGTGCAAAGACTAAACACCCTTTTGCATCCCTATACCTACACCTCCATACTATTATGTTTTGGAAAAATGTACGTCAAGAAACCATGTGATTTGGCCTGCAAGCACCTGAAGTCGAGGGTCTACTGCTACTGCATGGATCATCTGGTCTTCCCCGTATTTTTCAGAGGCTTCGTGAGTTCGTGTGGGTAGAGATCACGTCACCACCGCCCTTCCCGGCAGCGTTGGCCTCAGGTCCGAGCACCCGGGCATCACGAGGGCCATGGGGTTGTCGATGTCGTGGGACCCGTGGCCCCGCCCGGTCGCGACCCTGGCCTTGTCGCTCGCCGCCCAGACGCGGGCCCGTCGGGCACGCTGTCTGGCATGGCGGCGGCGCCTCCTCGATGGCCGTTCTTCCCTTGGTGGAGAAAACAGGCCCACGCGAGTGGTGGCGCCGCCGCTAGGTTGGCGTCTTCACCGGGGCGTCAGCCCACGCAAACCCCCGAAGAGCCAAGAATTACGGGGTTTTGGGATCGTTTTCCCGAACATTGTGAATATGTCATCCGGCAAACTTGCAGGTTAGGTGCGGGAGCTTTGCTTGCTCCATCCGACTGAAGAATACGAGATAGAGGAAATAGACAGGCCTGCCGCTACAGTTGCTCTTGCGAGGACGAAGCTCCGTTTCCAAGACGAATCATGGACTGCACTGACTCGCCTTTGCCGATTCGACGGAGCTGACTCGGCAGCAGAGTGGGAGCCGGGTGCATGAAAAGTGAATAGGTACGGAGTCGACCCATTCACCGATATCAAAGGAGCGGAGCCAAAGGGGTAGATTTCGTTAGTGTGTAGCGAGGCGACGCAACTTGTCCACAGAGAAGGCACGTTGCCGCTTGCTTGTAGTCTCGTAACGTGATTTGCTGCTAATAATCTATTGATATCCCAACTATTAATTGTTGTTTCATGGTACTATTTGCAGCATGAAGTTCTCTGACTACATAGGTCGCCACCATGTGTTCACCACACCCTCCCTCCTCGGGGCCATGGACTCCCCAGCTGCGGCCGAGGAGCAGCTACGGCTCGCCGTGAGGTCCGGGGCCGTGGAGCGCGTGCGGCGTGGGCTTCTCGTCTCCAACCGCGGGCGGTTCGAGGACGTCCCTGTGGACCAGTTCGAGGTTGTCGCGGCGCTCGATGCCAGCGCGGTCGTCTCGTACCACTCGGCTCTCGAGGCGCACGGCGTCGCGCACAACGCGGGATTCGTGTGCCGCTTCCGCTCGGACACCGTGAGGGCCGGGTTCGACTTCCGCGGCGTCGCCTACCGTCCCTGCGGCCCGGTGAGGAATGTGCGGTCGAAAACTTTGAGATCTTCTTGGGGACCCTACCTCGCTACCACGAGGGAGCAGACAGTAATTGATTGCCTGGGGAAACCCGCCTTGGCGGGAGGGGTCGAGGAGACGGTACGCAGCTTGACCGCGTTCGTGTACCTCGGCGTGGAAGAGCTGGTCGGGCTCGCCTCCGAGGCAGGTCCCTCGATGGCCTCCCGCGTCGGGTGGCTGCTGTCGGAGAAGGGGGATGAGTGGCATGTGGACGAGGGAGATCTTGCCCGACTCGAGAGCGCGCTCGGACTTGGCCCCTACCGTCTGGGGTATGCAGCAGATGGAGCCCCAACGGGCTGGTCCGCCAAATGGAAGCTTATCCTGCCCGAGAACAGGGAGGAGATGGAGTCGTGGATAACGCGCTCGTGAGGGAGTTCCCGCCGCGCGCGCTTGACAAGGTGGAGAGGCTTCTCGACCTGCTCGCCGAGCTCGGCGAGCATCCGTTTCTCAAAGACAAGATCGCGCTACACGGCGGGACCGCGATAAACCTGTTCATGCTCGACGCACCGAGGCTCTCCGTCGACATCGATCTCTCGTACGTCGGAGCGCTCGACAGGGACGAGATGCTCGCCGAAAGGCCAATCGTCGTGAGGTCTATTGACGAGGTGGCCCGCTCTCAGGGATACCCCGTCTTTGGGGCGCGAGGCGGGCATGCCGGCAGGACGTTCCTCCTCGGCTACAGGTCGCAATGGGGTCCAGACCATGTCAAGATCGACTGCATCTACATGAACCGCTCTCCGCTGATGCCGATCGAACGCAGATCCCCGATTCTCAGACCAGAGTTGGATGTCCCGCTCTTTACCGATGCGGAGCTTGCCGGAGGGAAGGTCAAGGCGTTCTTCGATCGTGTGAAGGTGCGGGACCTCTATGACGTCGCGAACCTCAAGCGCGTGCTCGACGGAAGAAGCGCTGCTGAGCGCGCCGTCGCTCACAAGGCGGTTCTCTTCTACGCGTCGCTTTCGGCGTCGTTCCCGCACGGGTTCGAGGACCGTCCCGGACGCTTCGCCGGCAGGGGGCGCGAGCTCGAGGAGCAGCTCTTGCCCATGCTCAGGAGAAACGAGAAGGCGCCCACACTCGACGGGCTGATCGGAACTGCGCGAGAGTTCGTCTCCGCCTATGTCTTGCCGCAGACGGATGCCGAGGAAGAGTATCTCGAACGGTTCTCGCAGGGATTGCTCGTCCCGGACCTGCTTTTCGAAGACGAGGCGATGGCGCGTGCGGCCGCCGCCAGCCCGGAAGTCCGGTGGAAGCTGCAGAACATCCGCAAGATGCGAGGGCATGGCCATGGAGGTGCCTAGCTGCATGTAGCCACTTCTTGCGTACGTGGACATGTCTTCCCAGCTCAGAGGTGTCACTCTTCAGCTGGGAATTATCACTCTTGAGTCGGAGAGCTCCTCACTTTATCAGAGCTGTTTTCACCTATGTAGTCAGTTGCATGCAATCAAATCGCATCTCCGCACCGAGCCTGTCACTCTTCGGATGCCCGAAAATACTCTCTTGAAGTGACTACATCCCGTGTAGTCACCTCCGACTACACGGTGGCTACACGCTTTTTCAGATGGAAGAGTGATGGGAATCGCAGGTCAAGCGGCACGCTGACTACACGGAGATGGCCGATGTGACAATCGAGTGGGAGTAAGGCAGAGGTGGCTTGCAGGTTGCAACTTTAACCAGCTGACCTGCAGTCATTCATAGCTTGAGTTCATCTAAAATGGACCTGTGGACGAGATTTGACCCGCCTTGCGCCCTCAAATCGACGTCGTGGGCCTTTTTTCATGGGCATCCAAGGGTAGCGTCAGGTCACGGTGGTCGAAACTGGCCCATAATGATCAAGGCTCAGCTCACGTATCGATCGACGCTCAGCTCACTTCCCTTTATGGTCGGAATCAACCAAGAATGGCAGTTTCCGATGTCGGAATCGGCCATCATTGGCAGTTTCCGAAGACTAGCATATACTGAGATGAAGACCGGAAGAGAGGCGACAGGGGTAAGCTGCCGCCTGCGCACAGGCATCCGCACCACATCGGGAGGTCGCATGGAGCGTGAGGCGATGTCACAGCTAGAGGCTTGGATGACCTCCTCGCGTCGAAAGCCGCTCATCGTTCGCGGCGCGAGGCAGGTAGGCAAGACGTGGCTTGTTCGCGAGTTTGCCCACAGGAATTTTGGGGCCCTTGCCCATATCGTCTTTCTCGAAAATGAGGTCATGAGAGCTGTCTTTGACGGAAGCCTCGATCCCGATCGGCTCCTTACCGCCATAGGTGCCTATACAGGCACAAATTCACTTGATGGGAATACCCTCGTCTTTCTCGACGAGGTTCAGGAATGCCCCCGAGCTCTCACGGCACTCAAGATGCTGTGTGAGCAGCGGCCAGAGGTGCCTGTGGTGGCTGCAGGCTCTCTTCTTGGCATCGCACTGAACCGCGCAGACGACGCGCAGGGTAACTTGGCCCGCATATCATGGCCTGTCGGCAAAGTCGAGTACCTGAATATGCACCCCATGACATTCAGGGAGTTCTTACACGCTGTGGGCCAGGGCCAGTTGGCTGAGCTCATCCGGCCCGATGCGATCGAGCTGGTAAGCGCGATGGGCGAAACGTATGAGGACCTGCTGCGCAGCTACCTGTTCACGGGCGGCATGCCCGAGGCGGTGCAGGCATACGTGGATACGCGCATGCTGGGTGCAGCACGCAACGTCCAGCAACGCCTTCTGCTCGACTACGAGCATGATTTTGCGAAGCACGTGAGATCCGCATCGGAGGCGGAGCATATCCGAGAGCTGTGGCGATCGATCCCAACGCAAATCGCCCGCGAGACGGGAAGCAACAGATTCATATACGCTCAGGTAAAGAGGGGCGGTCGAGGCCGAACGTACAAGGATGCCGTATCGTGGCTCACCGACTCGGGCCTTGTTACCAAGGTCCAAAGAATCACAAGACCCAACATCCCGCTTCGGGCCTACGAGGATGACAGCTCGTTCAAGCTCTACCTGCTCGATGTGGGGCTGCTGGGCGCCGCACTGCACCTCGACGTGCGGACCATCTTGAGGGGAAACGAACTCTTCACGCACGCAAAGGGCGTCTACGCCGAGCAATACGTATGCCAACAGCTCGTCGCGACAGACGGAATCAGGCCCTCGGCCACTGGCAGCGAGTCACAGACGACCAGCATGGCCCCCTGGTACTGGTCGGCGGACGGCAAGCGCAGCAAGGGAGAGGTCGACTTTTTGTATGAGTGCGACGGCAGGGTAGTTCCCCTGGAGGTCAAGGCGGGTACAAGCGTCAAGAGCGGAAGTATTGCCAGGTTTGCGAAAGAACACGGCATCACGCGGAGCCTTCGGCTGTCGCTGAAGGGCTATGCCGACCAGGGCTGGATCGTCAACTATCCGCTCTATGCGGCAAATCTACTGCCGCTCGTACCGTAAGCGCCTGCCCATGGCACCATGCGGGCACAGGCTGCGAGCTATATTGGTCGTAGAGCATAGTAAACCTTGGACGCGGTAGGAGCACTGGGGGACAGGTGGCGGCGCAGGCCGCACTGCCACTCGATGGTGAACGTACGGGGCCGCACGCTCAGGGCCGAGTGGCAGTGCGAATTGATATGTCCTTTGGGCCCGTAGGCATCATACTGGTGTCGAGGTAGGCCTCGACCAAAGACACCTCGACCAGGGCGTGCACCTCATTTCGTCTAGCCGAGCGCACTGAGATCCACCTCATACGGCAGGGTCTCTGGATGCGGTCTTGGCTCGAGGAACATGCTCATGTAGAGGGGCAGGTATGTGATCGCCCCCGACTGCCTGACGTTGCCCTTGCATAGGACATAGGCATGCCCAAGATCCCATTCGGAGACCTTGAGCAACTTGTCGAGGGCAGGGTGGGACGCCCAGTCATTTCCAGACTTCACCTCGATGGGTATGACATCACGTCTGTCTTGGACGACAAAGTCAACCTCGCCGTAGCGCTTTGCGTTGAAGTAGTGGAGCTTGAAGCCATGGGCATCCAGCTCCTGCGCCACTACATTCTCCATGATTGAGCCAAGGTTAACGTGCAGGTTTCCTTTGAGCAGATCAGGCGTGCGCTCGCGGCGGAGGGATGAGGTCGGCCGCAGAGGGGTGACGTGCTTGGCCCATCGGCGGTCGGGGACTGACGTACGCTCGTGACCTGGCCTTACCGGACAGGCTCTTGACAGGCTGAGGCCCCATATCTCGCCAACAGGTCGTCCTCATGCTTCACGAGGTACTCGCGCATGAACGGCATCGAGAACGCCACGTACCCGGGTGCCGTGGCCTCGATGACCTGGCGGCTAATGAGCATCCTGCGGTACGTGTTGGCGCTGGCGGCCGGCTTTCCCATACGCCTCGCGACCGCGGCGGTGGAGGATGCGGCGTTGTCTTCAGTCATGGCCAAAAGATAGTCCAGCGCGGGCTTGGTGAGTCCGGCAAGCGCCGTCTCGATCATCGACTGCCCATACTGCCTGACCGCCGCCGTCCCACGACGCACGTCCTCCACGTCTATGGTCACGGACTCTGCGACGTGACGCCGCCCCTCTCGCCAAATGTAGTATCCGACGAGTTGGATGAGATACGCATAGCCGCAGGTGTCCGCAGCGGCCTGCGCGAGCGCAGCGTCTTCGATCGCAAGCCCCGAGGCCTCGATGGTCTTCCTAAGCGCTCGCGCGACATCAGCCCTCGGGATGCTCGCAAGCTCCTCTGCCTGGGCACGACGCAAGAACGTGACGCCCTCGCCGTTCAGAAGATCGAGCACTCCCGTCGTGATGCCCGCGAACAAGAGCCCGACATTTTGCCCCTCGCGAATCATGTACTGCACGTTTGCAGCGATGACAGCCATGTCATCACGTGAGGCATCCTGCGCCTCGTCCACCGTGATGAGCAGGCCTGCGCCATCCTGCGAGAGGGACCGCGTGGCACGGGCGAACACATCGCGAAACGAGGGCTCCCTGCCAGAGTCGCCAATCTTTGCTCCTGCCGACACAAACGGAAGGGAAATCTGGACGTTCAGGTCTCTGAGCCGAGTGTCCCCCACGAGCTGTTCCTGAATCGAGGCGCAGAGGGCCTCCTTGCCTGACACGTTGACGACAGACCACCCACGCCTGGTGGCGATGTTGCCAAGCGCCGTCAGGAGCACCGTCTTTCCGGAACCGCGAGGCCCAGTGATGCGCATGAGGCGACCAGGCGCACCCGGACCCTCATCCAGACCATCCATAAAGTCATCGATCACCGATTCGCGGCCGACGAGCACCGGTGGGGTCATGCCTGCGGTTGGCTTGAAGGGATTAACGTAGATCTGACGCTCGGGCAAGGCCGCTCCTCTCTCGCCGATAGAAATCGTATCTCTAGAAAGTATAGAGAATCTAGGAGATATAGAAGTTCTCAAGCGACGTCATGACACTATCGGAAGCCATGCCGGATAATAGTCGCAAGTCGCTCACCCCGTGACGCAGACGACCTTCCCGAAGCTGTGTGAGCTCTCAAGGTAGCGATGGACGTCGACCACCTGATCGAGCGTGTACACGCGCTCGGGCGCAACGTCCACGGCCCTCTCACGTATGTAGTCAAGAAGTTCCTGCATGAGGCTGGGACTCACGTTTCCGGAGTATGCGCTCGTGAGGTAGCCGTTACGCGGCAGGTCATCGATGGGAGAAAAGTCGTCGTCCATGTACCACTTACCTCCGAGCAGGCCTGTGGAGCAGACGATGCCGCCCTCCGTCGTGTGCCGACAGCTGTCCTTAAGCGTCTTGGGACCGATGAGCTCGAGGATACGGTCGAAGCTCTCGTCCGTCTGCAGAGCGCCGTCCGCATCAACCACGGCATCGTCGAAGCCCGCAGAGAGGAGCCTCTCTTGCTTTGCCACGGATCGGGTCGTACCGCAGACCGTGACGGACAGTCTCGCCGCGTGCGCGAGCCGCGAGAAAGCGACCCCCACGCCGGCGGTCCCGCCGCGCACCAGCAGGCGGTTACCGCTCTCGACGCGCAGGTTCTTGAGCGAGAGCCACGCCGTGTAGTAGGTCTCTGGAATGGCCGCGAGCGTCGCCCAGTCGCCGTCCCACTCCACGGGGCAGACCTGCTCGTTGGGCAGCAGGCAGTACTCGGCGTATCCGCCATCAAACGCACGGCCCATCTCCCCCATGATGGAGACGACCGTCTGCCCCTGCGGCAGACGGTCGGGGTCCGTGGTTTGTGCCACCCCGCCCACGCACTCGATCCCCAGGATGCGAGGAAAGCGCACGCTGGGAGAGAGGCCCTGGCGGGTGAATAGCTCGGAGTGGTTGATGCCGAAGCCCCGAACGCGCACGAGCGTCCAGCCGGGCTTTACCTCGGGCGTAGGCACCTCCATGACGACCAGCTTCTCTGGCCCACCGGCCTCAAAGACGACTGCCGCTCTCATATCGCTCCAATCATAGGGGGTCCCTGGCAGCCAGTATACAGCTCCCAGCTTTCGTGACAGTCACGCGCCAGGGCCCCGTCTCGTCAGGCCCCGAGGGATCCAAGGAACCGCCCGGGAATCTGCGGGGCACTTTCCCTGGAACGTTTGCCCAGTTGGCGTATATTCTTAGGTACCCGGGAATCTGCGGGGCACTATCACGCTGTCTAGCAGGCAGGCCGACAGTCAGAACGGCAGCCTCGCTCACTCGTCGTTGTGCGCGACGACCATGACCACGTTGCCACCGAGCAGAAGCATGACGCCGAGGATGACAAGCGCGGTCTGAGTCGGCTCCGCCACGAAGTCGGCGGGCAGGTACAGCCCACCCATCAGCAGGAAGATGCTGATGATGATCGCGACGAGGCCAAGCATCTTCTGTGTCGCTTCGCTCATCGTCTTGCCTCCTCGCCTCTGCCGTCGCCGCAGCGGGAGTCATCCGGCTGTGCGCCTCCCTGCACCGGCGCCACATCCCAGCCGCATGCCCGCTCGCCTGCCTGCACCATGCGACGATAGACGCCGTCCAGCGCCATCAGCTCGTCGTGCGAGCCGCACTCGAGCACCTGACCGTCACCTACGACCGCAATCCTGTCGGCGTTTTGGATGGTGGGCAGCTTATGGGCAATCACCAACGTCGTCTTACCGCGACACAGCTCCGTCATGGCCTGCTGGATATGGCGCTCGTTGTCGGCGTCGATGCTGGCGGTCGCCTCGTCGAGCACGACGATGGGCGCATCCTTGAGGATCGCCCGGGCGATGGAGACGCGTTGCGCCTCCCCGCCGGACAGGCTGGCGCCGCCCTCACCGACCATCGTGTCGAATCCGTAGGGCATACGCATTACGAAGTCGAGGCAGCATGCCTTTCGGGCAGCCTCGTATACCTCCTCGCGCGTTGCGCCGGGCCTACCCATGGCGATGTTGTTGAACACCGTGTCCTGGAACAGATAGACGTTCTGGAAGACCATGCTGATCTGAGCCATGAGCGCCGAGAGCGGCAGCCGTCGCACATCGACGCCGCGCAGCAGCACCTGACCCGCAGAGACGTCCCAGAATCGTGCCAGGAGGTTCGCAAGGGTAGTCTTCCCGCTTCCCGACTGCCCTACTAGGGCGACCATCTGACCGCAGTCGGCTGCCAGGGAGACGTCCCTCAGTACGTTTTTCTCGCCGTAGGAGAAGGACACGTGCGAGAACTCGATCTCGTGACTGCCTAAGGCAGCTGCGGCAGCCGCATCGGGCAAGTCATCCGTGCCCGCATCCTCCAGCTCGTCTTGGGAGAACAGGGACTCGATGCGGTTCAGAGCGCTCTCCATGATGGTCAGGCGCGTGCTCTGCTGGTATAGGTCCCTCAGCGGTCCGAACAGCTGGAACAGGAACAGCGCGATGCCGACGAACGTGCCGGGCGTCATGGCGCCCTGCTCCAGCTGCCATACGGAGAGCGCAAGCACCGCCGCCGACCCCAGGCCATACAGCGCCAGGAGTGCCGCCTCGAAGGGCGACTGCTCGCAGGCAAAACGCAGGCTGGTATCCCGCGTGGTCGCGAAGCTATCGCGTAGATCCTGTGCCCCCTCGCCCGTAAGGTTATAGCTCTTGACGACTGCGAGACCCTCGACGTACTCGAGCACCGAGTCGGTCAGTCGCTCGATCGTCCGTTGGCGAACGTCTGAGTTGCGACGCGCCTGCGCGAGCATCGGTTGGGCGACTAGGACGGCGATGAGCTCGACCACCAGTACAATCACCCCGACGAGAGGGCTCATCGTGAACAGGAACACCGTCAGGATGACCTGGGAGAAGACGTCACTCATGACGTTCGCGACGATCGACATGCTCTGCTCCTCGATATAGACCATGTCGGCCGAGAGGATGGAGCTGATGCGCCCGATGTTGCCTGCGGTGAAGAACCCCATGGGGAGGCGACGTAGGTGCTGGCCCAGCTCGACGCGCTTGTCAGCGAAGATCTCGTAGCCCGTCCCCGACTGCAGGCGATCGGCAAGGTATTGGAAGATCGACTGGAGCAAGAGGAGCACCAGCATCCCCGCCGCAAGAAGGCAGCAGGAAAGCGGCGTCGCCTGGCCCGCCATGAGAAGGCGCAGCGCCATGATGGCAAGCATCAAAGGGGCGGTGGCGCACAGCGCCCTCAGAAACGCAAAGACATAGGCGATCCGCACGCGCCGTGCGTAGGGTCCCGAGAAGGCAAGGATGCGGTGGACGAGGCCTAGCATGATAGTGCCTCCCTGCCGCCTGCGCCCTGAGCGTCGATGCGCCCACCATCCCTGAGCGTCCAGCCACTCACCTGCTCGGAGGCGTCCCACAGCGCTCTGTACTCGGGACAGGACGAGAGAAGCTCGCCCTGCGTCCCCTCTGCGAGGACACGACCCTGATGCAGCATGATGATCTTGTCGGCACCCGCGATGGAGCGGAGCTTGTGGGCTATGACGATGACCGTCTTGCCCGCGATGATCTCGCGGATGGCACGGCTCATCCTCTGCTCGTTCTCCGGGTCGACGAACGCCGTCGCCTCGTCGAGCACGACGATGGGCGCATCCTTGAGGATCGCCCGGGCAAATGCGATGCGCTGGCGCTGGCCACCCGACAGTCGCCTTCCCGCCGTTCCCGCATTAGTATTGTAGTCGTTTTCCAGATCTCTGATAAAATCGTCGCATTGCGCCCGCTTGGCGGCCTCAATAACCTCCTCGTCGGTCGCGTCGGGCCGGCCGACGCGGATGTTCTCGAGGATGCTCCTGTCAAAGAGGAACAGGTCCTGCGACACATAGGATATCTGCTCGCTCAGGGCGACCTGGGTCATATCGTCGATGTGCTGACCACCTATAGAGATGGAGCCGCTCGCCACATCGTAGTGGTGGACCAGAAGGCGCGCGATGGTGCTCTTGCCGCTTCCGCTCTCCCCCACCAGCGCGGTCATGCGGCCCTCATCGGCCGTGAACGAGATACCCTTCAGCACCTCGGCATCGCGGTATGCGAAACGCACGTCCTCAAACACCACCCTGTGGCCCCGGCCGACAAAGCCCGCGCTCCCCGACTTGAGTGGCGCCTGGTCCAAGGCCTTCTCAAGCACTTGGATCTTGAAGCTCACCTGAGGGATGGCACCGATGAACGCCATGCAGTGCAGCAGCAGCGGTCCTATTCCGAAGCTCAGGCACAACACCAGCACGCAGCTCGAGAGCGTCATCCGCCCAAGCAGCACCATGAGCACCCCAAACGGCAAAGAGTACAGCACAACGCTCGAGAACAGGCTGCCGTAGAGCGCCATCCAAGGCCAGCAGATCTTGTACCATCCCAGGGCCTGATCGCGATAGCCCGACACCGCACGCTCGAACTTCTCGCCGGAATCAGCCTGACGGTTGAACACGCGTACGACCTCCATGCCCTCCACGTATTCGACGATGGTGTTGTTCAGGCGCTTCGTCGCGGCAAAGTAGCTGCCCATTTTGTCGATGCCCACGCTGTACATCTGCCGGGACACGATGACGCCAAGCCCCACCACGATGAGGGTGAGAAGCGCCATCTGCCAGTCAACGGCAAATGTCGTCAGGAGCACGACTGCGACAACGGTGATGTTCGCTGCACCCTCGGGGATCATGTGTGCTAGCAGGAGCTCTATGGACTCGATATCGTCGGTGAACAGCTTCTTCACGGCCCCCGCGCCCAGATCCCTCACCGTCCCGATGGACTGGCCGTCTAGTCGCTCCTGCAAAAACTTACGCAGATTCTCGAGCGTGCTGAACGCTGCCTTGTGAGAAAGCACCAAGCCCACCGTGTAACTTGCGGCATGCACGACCTCGCAGACGGCAATCGCTGCAACAGCGGGGGCTGCGGCGGCAAGCGTAACGGTACCACCCGAAAGAGCCGCATCGATAAGGCCGTAGATGAGCAGGTAGGGAACGACGCTTGCCAAGGCCCCGACGATCATCAGCGTCGCCGCGAGCGCGATCGACCTTCTCTGCTCACCCGCATAGCGCAGGATCTTGCCCACCGCTCCGGTGCGATCGCGCCTTTTGCTGGTGCTCTCATCACTGGGAGACAGAAAATAACCGCGCACACGGGCCGCGCCCTCATCGTCGAGCGGATAGAGCGCCACGGCTCGACCGTCGCGCACATGCAGCACGTGCGTGCAGCACTGCAAGATGAGTTCGGGGTCGTGCGTGATGATGAGCGAGCAGAGCACCTTGTCGCGCATGGCGCGCAGAAGCGTGCCGAAGCGCTCCATGCCGCGACGGTCGAGGCCACTTGTGGGCTCGTCGTAGAACAGGATGTCCTTGCCTGCGCAGAGCGCCGAGGCAATGGCCACGCGCTGCTTCTGCCCACCCGAGAGCGAGGCGGGATGACGGTCCTTGTACTCGAGCAGGCCCAGGCCCTCAAGAACCCGGTCGACCTCCTCCTCGGAGACTGACGCGTTCAGGCTGACCTCCTCGGCCACGTCATCCGCGAACAGCTGACGGTTGACGTCCTGCATCACCATAAAGCTTCTCTTGGAGCGCGTCCGTGCGGTCTCGAAGGTCCCGCCTATCGCCACCGTGCCGTCGGAGGGAATGATGCCACAGAGGGACTCAGCCAAGGTACTCTTGCCGCAGCCGTTGTCCCCTATCACCGCCACCACGCTATGCACGGGAAACGCGATGCGATCCACGTCTAAGATGCGCGCGCTGCCCCGGCTGCAGCTGAGGTCAACCGCCTCGAGGGCGGGGCGCCCGACAGTGCGGGCGTCGGCGTAGGCATCGTCGTATGGGCCATCCTGCCCTTTGCCACCGTTGCCATCCGGGCCGCCACCGGCGGGCGACGTCGCCCTGACCCTGACGAGCCGACGCAAGTCGGTGCAGCGCAGACCCAGCTCTGACAGCCGAGCGTCGTCGAGCAAGCGCAACTCCTGCGTGGAGAAGGTCCTCTCGATACGCCCGTCCTTGACGTAGACGAACTCATCGGCCAGATCCATCAGGTAGTGGAGGCGATGCTCCGACAGCACGATGGTCTTGCCCTCGTCCTTCATCTTCGCCAAGATGTTGTGCAGGCGTCGTATCGCCTTCTTGTCGAGATTCGCCGACGGCTCATCCATCACGAACACGTGTGGTCCGGACGCGTAGACCGAGCCGCAGGCGATCTGCTGCTTCTCGCCGCCGGAAAGCTCAAAGATGTTGCGGTCCATCAGCGCGTCGAGCTGCATGTCGATGCGCGTCCTGTCGAGCCTGCGGCGCATCTCGTCACGAGACAGAGCTTGGTTCTCGCAGCCGAACACCAGCTCACCTGTGGTGTCCACGTTGAAGAACTGGCTCTTGGGATTCTGAAATACACTGCCGATGAGCGCCGCCGTATCATGGAGCTCTGCGGTGGTGGTGCAGATGTCGTCCACATAGACGGCACCTTCCATCTCGCCCTCATAGAAGTTGGGGGCAAGGCCGTTTATCAGGCGCGTGAGGGTCGTCTTTCCGCATCCGCTCTCGCCGACAAGCACCGTGAAGGCCCCGTCTGCTATCGTGAGATCGATATGATCGACGCCGTCTCCGGTGCCGCTCTCGCCACCGTAGTGAAAGCTCACGTCATCAAAGCGAATCATAGGCTGCTCATTCCTGATGCCCTGAAGGCAAGTATCCAGGCGGCAACTATGATAAAGAGACTGATCGCTATGAGGTCGGCCCCGCCAAGCTGTATATCCTCGAAGGAGCTGCGCTTGCGCGTACTGTCCATCCCACGTGCCAGCGAGGCTGCGGCCAGCTCCTCCATAACACCGACGGAGGAGAAGAGCAGGGGTACGAGGATGTACTCGATGGTCAGGAGTGGATGTCGAATGATCGCCCCCGGCGTCATCGATATGCCACGAAACGCCATCGCCTTGCGCACGCCGCTCCACTCGTCCTGTACCGTCGGGATGAAGCGAAACAGCACTGCCAGAGGGATGACAAGGGTCATGGGTAGGTGCATTGCCTGGAACGCCGAGAGGAACTGGCTCACCCGCGTGGTGCGTACGAGCAAAAGAAAGGAGACCATGATGGGAAAAAAGAACACGAAAAGCGAGATAAGCCCCATACACACACTAACGACCGCCTCTGCACCCTGCTCCCCTGACGCCTCAATGCAGTAGCGGATGAACAGGATGACATAGAGGCTCGCAAGGCATTTGAGCGCCAAGGCCTGCTTTCCGGACAGAGTGAGCATGACGCACTGCAGCGTACCGACCACCAGGATGGGAAGGTTGCCGTGCATCGAGAGGCTTAGAAAGCAGCTCACAAAGAAGACCAGCAACTTCGTACGCGGATCAAAGCGGATACGCGCCCCTGAGTCATCACCGTAGAGTTCGAACTCCACCTAGACGATCCCAGCCTTGGCAAAGTGCTTCTTCACGAGCCTGCTCGCGACAAGGGCGCCAACGGCCCCTCCGACAAGTGCGAGGGCAATGGTAAAGACATAGAAGCCGGATCCGAAGAGAGTCTCGTATGCCTTTGCACGAGCTTCCCCATAATAGTCTTGCGTAACCTTAAGAGAATCTTGAAGATTGAACACAAAGCTCAGATACGGTGCTGCCATGGTGAGGTTGAAGAACACGTATGAAAGCAGGTACATCTTCTTTGATGTATACTTGCCGAGGAAAATCATGAGCTCGGCGATGAGCGAGGCACCAAGAACCACTGCAAGCGAGTACCACGTGAGGTGGCCGGTCGCCAAGATAAAGAGTATCCCCAAGATAAGCGCCGCGCCAAACTTATGTATCTTGAGCACGTAGAGCATGTAGATTGTGCCGCACACAGTGCCGACGGTGAGCGGGGCGATGAAATACAGGATGGGAAGCACTATGCCCGAGCCCATCACGACGATGAGCATCGCCACGATGTAGAGTGCACAAAACGCACCGGCGTAGATGAGGTCCTTCGTGTTCAGCTTCCCACCGCCCTTGGTGGCGGCTTGAACTTGGGATTCCTGTGCCATGCTATCCTCCTCTTGCGATAGTGTTAAAAGCAGCTAACCAAATGGTGCGACACACTATACGTTTTCCTACACAGCATGTCAACCATAGCGTACTTACTGCAGCCACTGCACTATGAGTCGGAGAAGGGGTGCGTTTACTGGGCAGCGTGCGGAGCCTGTGCATCCGTAGTGCGCCCCATGCAGGGCCGAGAGGAAGGAATGCGAGTGAGAAGAGGCGGGCTGATACGTTGCTTGCTGAGCGTATGCACTCCCACAAGCCAACCCGTCCGCGCCTCGTGGAGCGCATACCGCCCACACGGGCATGGCTTGGGCTTCAACTGCAACGCCATGTGAGGTTCACGGCCGGGACGGGCGCGGTCCACCCCGGCCGTCCGGGACTATGCCGAGGTAGCCATGTAGAAAACGGGCAGGCCAAGAAAAAGAAAGTCAAGGAGCCAGTGCCCAATGACAAGAGGGACGGTCTTCCTCTTCCATAGCCAGAGGCCACCAAAGAGTAGTCCGGCAAAGAGGGTGGTCAGGGCCCTGGACAGCATCTGCTGCCCGTCAGGAACAGCAAACCCGATATGCTGGAGCCCAAAGAAGACAGACACAAGAAGCAGTGCCGGGACCTGGCCCATGCGACGCGCGAGGCGAGGCAGAAGGTAGGAACGATACAGCCCCTCCTCGGCGAAGGCTATGGTCAGCGGCATAACGGCAAGAGCAAGAGCGCCGAGCCACAGCGGGGGAACGAAACTCGAGGGTTGGGCGGGCGGGGCACCGTGATAGACGATGAGGTTCGCCAGAACGGTCGAGACAAAGAAGCCAACGATTATGATGAGTGAAAACAGGAGTCCCCACGCGATGTCGGCACCACCGGTCGGAACATAGAGGTCACGCAGGCGTCGTCCCTCCCCTCTCATAAGATGAGCCAGCGTAGCGAAGGTGATGGCATCGACGACAATGATGCCGAGGTCGGTCCACAGAAGCGATTGCCCCGCAAGGTGAAGGCACACCCCCATAAGGAGGATGAGGACGAAACGAAGCGACAGGGCAAGGGCGAGGTGAGGCATGGGAGCGACAGGCTCTCCTGAGCCGCCGTGGGTGTCCCCGTCCCCAGATGAGGCGGACCGAGGCTGCAAGAGGTCTGTGTTCTCGTTCATGGTGGTCTGGTTTCCTTTCGACTTCCACGCCATCAGAGCACAGCGGATTATATCACCTGTTGCGTCGTCAGCATGACCAGTGCAGTTTCAGCATTCGCTGCACCCGATGCCCTGTTGCCGCGCAGCGAGACAGGAAGACGGGATGCCCATAGAACCTTTTGACAGCGGGACTCTCGCTGGTGACCTTACCCTGAGTTCCCGGCACCTCCTTAGCCCACAACTGGCAGCCTGATGGTGACCCGGCCTGACCCGGGGCGCGCCATCGGCGAGGCCCTCTGCCCAGACTGCGCTTTTCCGTGAGGCCGGGCCCGCCGGCCGAGGCCTGCGGGCCCCGGCGCACCCCCCCGCAGCCTGGCGGGGGGTTGCTCGAGCACGTTTGCCCAGTTGGGCCACTCTCCATAGTGCCCCGCAGGCTGGCGGGGGGTTGCGCCCCACGCCTCCCGAGCGGCGACGTGACGGAAAAGCGCATTCTGCGCAACGTGGGAGCCGCAGACTGCGCCTTTTCGTGAGGCATCGGGCCGGGAGGCGCCCCTCCGTGAGGCCGCACGGCCCTCCTCCGCAGCACCAACGCCGTCCCCCGCAGGCCTGGCGGCCGCCGCGCGCCCGTAGGTGAGAGCCTCATGCCGCATGGCGCCGGAGACGGCCGCCGCGCACAGGCGACGGCCCATGGGTCTCCACAGCCGGGCGCAGGCCCTCGGGGCAGGCGACGGCTCGGGTCTGTGTCCAGCGGGCTAAGGAAGCGCCGGAAAGTCGGACTTACTGCCACTCAGCGGTGAACATGTCGTGCGATACGTTCAGGGGTAGGTGGCAGCGCGGACCGCGCCAAGGCCCTGTGGGATAAGCGGATCACAGGTGATAGGTAACGTCACAGCAGAGGATGAGGCACCCAGCATGCCGGGACGGCGACATGAGATTGGTCACAACGGCTCTGTGCCACCACAGCGTTCGTCTCAGCCCCATGTGCTATATTCGAGAATACGTAAAGGCGATGTGGACAGGAGCGAATAGCCCACAGCTCGGAGATGGTCCTCATGCAATTCCTCACGGAGTGCTTTGTTCTTGTCATGCTGGTCCTAGCGGCATATTGCGTGTCCGAGCTGCGTATGTGCCGTCGCGAGATCGACGCCCTCAAGGACTGGGTACGAAATCTCAACAGCCGAGTTGAGGTGGAGGAGATGAGGGCGCGCGGCGACCAGAGGGAGTCGGCGGCCGCACCCCCACAATATGGCGGCAGCGAACAAGGCCCGCCCATCCCAGCGGCATGGCCCTACGCCAACGAGTCCGATGCCCCGAGTCCTTGGCCCTACGAGCACGGTGTCTCGAGCCCTTGGCCCAACGCAAACGCGCCCGTCGCACCAGCATCCTGGCCCTACGAGTCAGGCGCCTCGACGCCTCTCTCGTCTGCGCCCGAGCGCCCGCCGGTACCCGGGCGCCCACCTGCACCTATCTCCTCTTCCGGGCAACCTCCGGTACCCCCCGGCATGATACCGGCTGCTCCGGCTACCTTCGCCGCAATGCCCGAGGACAGGGACCTCGCCGAGAGGTCCGATTCGCTCGAGGGAACGTTTGGCAGAAACGTCATAGGCCTCGCTGCCGTCCTCCTCGTCTTCCTCGGCCTCGTCTTCCTCGGTATCCTCGTGATCCCCACCCTTGGCAACGAGGTCCGCTGCGCGCTCATGTGGCTTCTCAGCCTCGTCTTGGCGTCTGCGGGGCTGGCGGCAGCGCGACGCCGCGTGAGCGCCTTCTCGATATCCCTCCTGGGGGCGGGCATGGGCGCGATATTCATCTCTGTGCTCATGACCCACGTATACTTTCGCTACCTTGGCGAGGTACCCGCCTTCGGCCTGATGCTCGCCTGGATGGCAGCCTGCATGGTGCTCGTGAGGAGGTTCGAGTCCACTGCGCTCTCCGTGCTGGTCCATATGGGGATGGTAATCTCGGTCTGCTTTTCCTACTCCTTTGGCTTCAGCGAGACACGCCTGCCCCTTGTTATCACGTACCAGACGCTGTCCTGCACCCTCGTCGTGGCGGGTAGCGTCCTGTGCCTGAGGCGGACGTACCGGTACGGGCTCTTGGTCTCGCTCGTGCTCACCCTGATTGCCAGCCTGTTCATGCGCGACTACTTTGGGGTGGGAGGCATGGGGTCCCGTGACACGTCCCTGTCCACCCCAATTGCCGTGGCCTTCTTCCTGCAGTTCGCAGGCGCAAGCGTCCTCTCTCTACTGCTGGCGCTCTCTGGGAAGGAGGAAGAGGAGCGGGACGTGACAACGACGCTGTACGCGATGGGCAAGCTTGCCTGGTTTGGCGTGCTTCTCGTAGACGTATGCGCCGTCGCACGCCAGCTGATCCTCCAAGCCAGCGGCCTCTCGGCGAGCACAGTGCCCCCTGGGAACGATGCGGCACGCGCAGTGATGCTCGCCGAGGCACACTCGACGCTCATCGGTATCGCCTGCCTAGCGGCAGGAGTCGCGCTGATCCTCTGGCTGATGCGCAAGCGCCTGGTGGATGCGGAACTCGGCAAGCTGTCCCTCTGCCTCTTGGGGGGCATGGCGGCGTTTCTTCTGTTACTGCGATATCTCTCGACGCATCTATCGCTTTTGCCCCAGCCCAATCTCTCCTATGTGGTTCTTGTCGCCGTTTACTTCTATGTGCTTGCGTACGCGATGCACGATTCGGCGTATGCGTCGATCGGCGACGTCACCTTGGGCCTGGACGCCCTGCTGATGCTGACCTCCGGGTACGGTGAACTGGTTGAGCGAGCAGGCGTGGGCACCGCGTTTACCTATGTCGTGATGCTCACGGCATTGGCATACCTCTCGTGGCGCATTCGCTCGAGAGTTGTCGAGGCCTTTGGTGGGGATGTTGAGGCTCCCAGGCTCCGCCCCCGCATGCTCACCTGCCTGGCGGTGGCCGAGCTCTCGATACACATCATCGTGAACGCGGCAGGTTACCAGCATGCCCAAGAAATCGTCGCGGGGATTCTTGCCGTACTGCTTGTCGGCGTATATGCGCTTCAGGCGTGGAGACGAAGGGTGGCATCCGGCACGTTTTGGATGGGGGCGGCAGTCAACGAGCTGGCTGTCTCCGCTTTGGTTAGCCTGTGGGCTCTCACGGGAGATGCCGCGGGCCTGTTGCCTAGCCGACCGAACTCACCGGATACCTATGCCTACGTCCCGTCCCTGATCATCCTGATGGCGCTCGTCGGCTTGCGCCTATGGGACTTCTTGTCCGAGAGGCCCCGACCGACGGAGGCGCTGCAAGTAGCGGAGGGTATAGTGTTCTCGCTGCTCGGGCTAGCGCTCACCCAATGCTCGACTGCACAGATGGACATTCCCTTCGCTGCCGGAATCGTCGTCATGATGACGGCTCTCATCTGCATCATCGTCGGTTTCAAGGCACTCCTGAGGGCGCTACGCCTGTACGGTCTGACGATCGTTATCGTCTGCGTCTTCAGGCTCGTGCTGGTGGACGCGGCGTTTCTCTCGCCTGTCGCCCGCGTGGTCTCGTTCGTCATCGGTGGTGCCATCTGCTTTGCCATCAGCGCGCTCTACTCTCGCGCGGAGCAGCGCATCAGGGGACGAGTAGGCGAGGGGGGCAAGTAGGGCACGATCCCCAAACCAGCCAGCGGTCGGCCCGGTCGCCACCCGGTCGCCTGCGAGACACTCGGTCGCCCCCGAAGCTCGAGAGCCGGCTCAGCGACGGACCACGGTCCTTCTAGAGCTACTGGTCGAAAGGTGGTTGGAAAGGACATGGCAAAAGCGGTCTCGCAAAGAGAACGTGTCTCGGTGCCTTCGGCCCCATGCGCAATGGCCTCGCCCCCATTGCATCTGCTCGTGGAGGACATCATGTTGAATCTTTACCTGAATTTTTATCTGCGCCATCAACGTGCGGCTGCGACCACATGCCTTCTGCTCGGTGTCTTCTACGCAGCGGGAATACTCTGCATAGACGTCCTCTTTACCGAGAGCACCCCAAACGCCGCCAGGCTGCTCTTTGTTGGCTGCATGCTCATGGGGGCTGTTTTGTTCCTCATCTCCCTCTTCCGCGCCCGGAGGGACTCTAGCCTTTGGCTTCCGGCTCACCTTTGCTCCATGATCGGCTTTGGGGTGGGTACGGGGCTAGCTGCAGGCACGACGGGCGCAATCGCCTGCGCCATGGCAGCGATAAACGGTATGTGTGCGCTTGCCGTCCTGCTGCTGCGTGTCGAACAGGATAGCTAAAGTGATGACAGGTGCCCGTGAGATCGAGGATGAGGGACCTTCTCCTCGCAAACGATCTTGTGGACGCGGCCTTTTCTTGATACGCTGAGCTTGAAGGGTACGTATATCCATGCGGAGTGCCCTTATGGATAGCGCTCTGCATCCTATCCTCGATTGAGGAGGGGGCAGTCTTCCTTAGATACTGAACGAGCCCTTTGATGCCATGGCACCCGACCGTCTGGCCTATGGTCAAGGGTGTTAACCCGTGGTCGAGTAGTCGAGAGGTAGCCTCCTTATACTCAGCTCACATTTGCCGCCGGGTGTGTTGGAGATACGCGGGACGCTTGGTCACGACAAGTCCGAGGCAGGTGATTGCGGGACAGGTGTGCTGCGGCAGCCATGCGATACCGCCGACCCCACTGGGAGGCTGGATTCGCCCAACGCCAACCCTCCCATCCCCCCAGGCAGGAAACGTGCTCGTCTCTCAGCAGCCCCTCGATGGCGCAGGGCACGTCCTTTGCCGTGTGGCGGTAGCGAAAGCCGCACTTCTCCTGGACCCTCTTCGATCCTATGTTCCCGTCAAAGTAGCCGCACCAGATGCGAGCAAGTCCTAGGGGCACGCGGAACCCGTGCCGCACCAGCTCATGGACCGCCTCCAAAATCAGTGCTGGTGACGGCATGGGCCGTACGTATGCGGACCAGCCGCTCGATCCTCTCCCCGTCCTTTGCGCTCAGCAGCACCGTCGTCTTCAATCCTGCCAAACCGTGCCTCCCGCCCTCGCCCTTCGTCAACGGGGCTATACCACACTTACAGTTCAATTACTTTATGATAACTATACTAGATCCCAGGTCATAGCGCTACATTTGGCAGCACCTTAGGATCATTCTTGAGATAGGAAGCTAGAAATTCACTCCAATCTTTAGAGGACTCTTCACGGAATAACTCCTTAAGGAAGTCAATCATTATGGCTTGTCGCCTTTTAGCCTCAGCTCTCCCCGTCTCGGTTAACATCATTGATGGAACTCTCAACAATTTGTCGAAGAAGTGTTGGACACTGTGCTTGCTTGAATTATTCCGATATCCATCTGCAGAGAGGTTGTTCACTTCAGGCACTAGCAATTTATTGAAGAAAGGGATTTGCCTGGATATCCCATATTTATGAACTCTAAGAATGCCTTCGGCGCCAATAGCATCGCACATATCAGCATCGCTGACGACCATTCCTTCAATAGTGCTTGGACGGACTCCTTCAAGACGTTTGCTAAATCCAATGGTTCTTATGATCTGCAAGATCGTTTCGTACGCCTTGCTCCCTATGCCAGCATTTTCGAGAAATCGTTTTGCATTATTGAGTTCTTGAGATTTATTGGTGCCCACAAGTTTGTAGTCATCAACATCATGCAGAAGGCTCGCGAGCTCAACGATATCTGGATCAGCTCCCTCGCTATCTGCGAACAATAGCGCTAGCGTTCTCACGCGCAAAACATGATCCAGGCCATGTCCACTTCTGTCATCTAAGGTATCCTTAATAGAACTAATGAGAGAGTTCTCTATGCCAATATCAACGCACATCTCAGCGCCCTCTTCTTGCAAGCGGATAGGTCTATATAATAACGCCTGTTGAGTAGTCCTGCTCGACTCGGCGGCTGGACCCTCTTAGCGTAACATTCGTGCTTATCCATTAGGCTGGCATGTGGAGGCAGGAATGGCAGGGGGTCGGGCGGGGGATCTCGACGGACCCAAGGGCACCGAGATAAAGCGTCTATGGGGGCAGGCGGTGCCCCTGCGAGAGGTCGTGGCGGCACGACCCAAAGACAGGATGGTCGGAGAAGGTCTCGGGCCGTCTCTTGGGCAGGACCGCGCCAGAGAGGCTGACGTCGGATGCAGGCTAAGATGCCCGCAGCCCCAACGTCGCCGGGGCCGGCGCCCCCGACCTCGCCTAGTCGCTAACGGACGGCATGCAAGAGGGGTTTGCCCGCGCCATCATCGATGCTCCTTCTCGACCGAATATCTTCTGTTCCTGTTCGCCCCGAAGGAGGAGGCGAGTCCCTTGTCGACGAGGCGATTGAGCAGCTTCTGCGCACCGCGCTGCGACATCCCAAGCAAGTCAGCCACTTCGGAGCTCCTGACGGATTCCATTCCCTCCATGTGCGAGAGCGCCTTCCGTTCCGACGCGGAAAGGTTATCGGAACTCTTTCCGCCATTATCGGAACTCTTAGCATGGTTATCGGAACTGCTGGGGGTTCCACCGGGCATTTCATTGCTCGAATCAGCTGAGTCACGAAGGAAAACCCCGATCTCCGAATGCGCTTGCGCATCGGCGTCCGCAGCGCCCGCGACGAGGAGCGAGAGCACCTTCTCCTGCCGCTCCACGAGGTTGACGCAGAAGAACGCGGCGAACGGGTATGGGTCATCGCCCTCCTGGAAGGCACGTATGGCGGCGATGTAGCGCGCCCTTGACTCCGCCTGTATGTTCACAGGCTCGAAGCCCGAGGACATGAGTAGGTAGTTGCTTATGAGCCTGCCCGTGCGCCCGTTGGCGTTCACGAACGGGTGGATGCTCTCGAACTCAAGATGGAACAGCGCCGCGACGATGGCCGGATGCCGATTCGTGTTCGCGCACATCTCGACCAGGTCTGCCATCCGCTCGGGCACGTATGTGCTCGGCGCCGGCTGGAAGCTGGTCCCGGTAATCTCGACCTCGACCTTGCGGTACACGCCCCTCGTCGCCAGGTCCTTAGCCTCGGCGAACACGAGCTCGTGGGCGCGCTTGATGAGCGCTTCTGAAAGCGGTGCGCACCCGGGCACCACGGAGCGCAGGAACCTGAGCGCGGCGAACCCGCCCTCAGCCTGCCTGATGTCGTCTTCCAGGCCGTCCACCTGAACGCCGCCGTAGAGCAGCGCCGTGTCGCTAAGAGACAGCGTGCTGCCCTCGATGTTGTTCGAGTTGTAGGTGGACTCGATTGCCCACGACTCCATGATGCGATCGTATGCATCGGGCTGCGCCGCCTTCGCCTCGTCGACCCTTTCCTGGAGCTCGTCTATCCGAGCGAGCACAGGATGAAGCGTTTCCAGCTGCTTGAAGCTCATAGATGCTCCTCGTCTTTAAACACGAAGATGCCGATTCACCGTTTGCGACAGTATATAATTTGCAGCAAGCAAATATATTGCAAACTGCAAAGGAACGGGGCAGGACCATGTCGTACAGCGAGCTCGTGAAGAGTAATGCGGACGAGACCGACATCCGCAGTTACCTCACAGGGGGAAAGCAGGTGGCGGTCACCTTCCGCATCCCCGAGAACCTCCGAGAGAGCGCGAAGGAAGCCGCGGAGCTGCGCGGCATGAGCTTCTCCGCATTCATGCGCGCGTGCATGATGGATGAGCTCTCGAAGAAGGTGCTCTAGCATGGCCGCTTTGACAGAGGAAACCACCAAACTTCGCTACATCACGCTGGCTCGATCGCGTCGTGAATGTTGGTGTAGGAGCAGAAACGCGCTGCTAGTGTAAATTACGCTCGTTTTGACCCAACCATCCAGTCCTGCTGACCCACCAATCCAAATTAAACTGACCCATGTCAGCACGCGGCGCACCCTCTGTGCATGACGGTCGAATAGGCGGCCGCATGGACATTGGAGGCACATATGCGTGTCAGCAGAAGGAAGGTCCTCGAACTCCACGACTTCGGGGACGGCCTTTGGAACTCAGCATGGGATATCTCTTTTGTTGCTCGCCATCACATCGATTGCAACCGAGAGTGTTCCAAAAATCAACGCGATGACGATGGCTCTACAGAATGCTTGATCCGGCATACTCACAGAGAGGCCATACATTGTTCCCAACGGGAGAAACGCTTCGATTCTAAAGCTTGGCCCAAGCAGGGGAGCGAGAGCCAGGTTGACTATGCCGTACACGATTCCGCTTCCATACACCAAAGCAACAACGATCCCGATGACATGGTTTTTGCAGAGGCGGATGAAGCACGACATCACATACGTCGCGCATACTAGCAATGCGCAATACGAGACGGCGAAACGGCCCAATTTCGAGATCGATCCAAAAGGCAGATCCGCATACCCAGCTATGATGAGCGTATTGCTCAGCGCGGAGGCCCCAAGCAAGAGCGATACCGTAAGAACGCAGACCAACAGGCAGATGACGGCGTTAGAGGCGACGAAGTACCATCTTCTCCTGACCGAACAAACGACGTTCTTTTCGTACCCTGTCCTTCTATAGGCCCCGGCGAACAAGGCGGCAAAGACGATCATCGTCATAGCGACGATATTTCCAGAAAACACGTCGCAGATGAAATCTACTTTATTTGAATGATTTGCGTCATGTTCAGACACACTGCTGTCGTCGATTATCACAATGGAGTTCTGCTCGGACGTGCTAGACGTCGTATCGGCGGGCGACGCATGGATCGAAGTGTCTGCAATAACGGCGCAGAGCACCGTGATCATCAAGAGAATGATCAGTATTATATAGAAGAGCCTGCTCTTAAGAAGCCTATATACGTCCATTCTCAGCACATGCGTCATCTTCCATCTCCTTGCGTGATCTGAAAGTAGAAATCTTCAAAGGACATGTCCTTGTTCTCGCACTCTGCCTCAAGCGCTTCTCTCGAGTTTTCGTAAACCAGCTTTCCACAGTCCAAAATGCCATACCTGGTTGCGACTTTGGACAATTCCGATAAGATATGGCTGGAAATGACGATCGTTGTGCCTGTTTCCCGGTTGATTTTGAGGATTAAGCTGCGGATCTCGGCGATTCCCTGGGGATCGAGACCATTTATAGGCTCATCCAAAACCAGAAGCTCTGGATTCCCTATTAACGCCATGGCCAACCCCAAGCGTTGCCGCATGCCAAGCGAGAAATCTCTGGTATGTTTGTTTCTCACGTTCTGCAAACCAACAAGCTCCAGTAACTCTTTTATGTGCTTGTCGGGGGCGTCAATGCCACAGCAGATGCATTTCAGCATCAAGTTGTCGGTGGCATTCATGTATGGGAAGAAGCAGGGCGTTTCTATTAGTGATCCGATCTTAGAAAAAGATTCAGACCCCTTGGTAAGCGGGTCGGCACCCAAAATTGACATGGAGCCGGATGTCGGCGAGGACAGGCCGCAGACTATCTTCATAAAAGTGGTTTTACCTGCGCCGTTCCGTCCCACCAACCCATAGATATCCCCTTCAAGCACAGATAGGCTGACCTTATCGAGGACGTTTTGACCATCGTATTTCTTCACTATGTCTTTCGTCACAATCGCTAAACTCATTACGCGACCTCTCCAACCAGATATAGGCTCACCCATCTATATCCTTGTAACCGATGGTTTCACGAGACATCCACCTATGAAACTCCGTGATAGCCTCCTCTTCAGCCGCTGCTTGATCCCGAGCAGGTAATTCGTAATATTCCCTGCTCAAGACGCGTCCCGCGCCTCCCCCTGTGCGGGGAAGAGCAGGCCGCACGCCTCGCGGCCGGGCATGTCCGCCACGTCTCCCCAGGTCAGGCCAGCCTTGTCGGCGGCCTCCCCCGCGAGCTTGGTGCTCCTCTGGGAGATGTGCCCGGTCGACCGTATCTCCCTCCCGGTCATGCCCCTCGCCGGCAGCCCAGGGACCGGCTTGGCCCTTATCCTCCTCGCCGTCCGCGTCACTTCCCTTCGTTGTCCGAATGGCGAATGGGACAGACCTGGGAAGCGGTCGCATTGGCGTGATTGGCGTCAGTGCCAAGCTGGTCGCATACGCGAGATTGGGTGGTCACTCATTTGGTATGGGCGGTCATTTACGACGCGAATAATCACTTCTTCTATCTGATTGATCCGAGACATTATTCCCCTTTGTATTCGTCTTTTCAGTTCTGATACGCGGCCTCATCGCCGTTCTCCTGCAGCTCGACCCAGGCGAAGTGCCAGTCGCGGAAGGGCTTGTTGATAGGTTTCTTGCAGCCAGCGTGGGCCAGCACCACCACGTCCGCGCTACGCACGGAGCGCAAGCCGAAGAGGTGGGCCAGCTCCAGCAGGTGGCGGAAGGCCGCATTGGCGTCCGATATGCCGAAGTCGCTCGGCATCTCCTCAGGCAAGCGCTTGCCCTGCTCGCAGGCGCGCACGCTGAAAAGGCTCACGTCGGCGGCCTTGGCCAGGTCGCCCTAGGCGAGCCTCGCGGCCTTCCTCAGGCGCTTGAGGGTCTCCCCCAGCGAGGGATGGGGCAGTCCGGGTTGTCGCAGGGCCCGTCGTAGCCCATCCCGTGGCGCTCCATACGGCCTACCTTTCCTTCGTCTCTGCCGACCCCTCTTGCCTCCAGCGCAACGACTCGGGATCCCATGAGGCATCATGCCCGAAGAATCCCCTGAGGGCGGGATCGAAGAACGCGGAGGCGAGCGACGATGCCGCCTCGAACGGGGCATACTTCTCGGGAACGCCGCTCTTTTTGGCGAACGCGGCGAAGCTCCCAGCCCAAGCTGCAGGTGCCTCGAAGCGCCTCGGCACGCTCATGCCGCGCCTAGAGCACTCGCACTTGATCGAGCGGACGAGATCCTTGAGGAGAAGGGTGACGTTCGTTGAGTAGTAGACGACATCGACAAGGTCCTTCATCCTCGATGAAGGCCAGCCACCAGGCTGCATCTCCATTATGGCGCACAGCTTGTCGGCCAGCTGGTCGGGAAGCGGATAGACGAGATAACCGCACGACTCGAGCCCCTCGACGCAAACCCTGTTGGCGGGAGATATGCGCTCCGCGGGCTGCGTGATGCTGCAGTCGAGCGACAGATCGACGAGGATGGGGTCCTTCTCCTCGTGACCCAAGAAGGTCTGGAATCGCAGCTTGAGCAGGCGCGAGTAGCCGTTCTCATCCAGGGATTCCTCCCATTTGTCCAACTTGAACGTGAGGAAGTCGCCCATATCCTTGCCAGCAAGCGCGACGAGCGCCGTAAGGGCAGCCTCAGGCGATTCTCGAGAAGCCGTCACGAAGTCGATGTCTCGCGTGGCGCGGCCGTCGGGGATGCGCGCGAGCAGCCCACTCCCGCCCTTGAGGATGAAGCGCTCATCGGGGTCGCTGAAAACCCTGCACAGGAAGCGGTCACGCAAAGCCTGGCGATAGCCGTCTCCTGGATCGCCTCCGCTGTTGCGTATCGCCTTCTTCAGGGCCCTGTCGAACTGGCCGCCGTTCTCGTACGTCATTCGTCCCGCCTTTTCGCTAGGAAAGCGATGATAAAGTCCCGCCGAGAAGCCCGGGACAGGGGCGGATCGCTGTCCATCCATACCTCCTACCTGCGGATATGATATAATTCGAGGTCGTTGGCGACTAGGTTGGGGGTATCCGCATGGCACAGCTCACATTCTCTGACGTCGAGATGGGCATGGGACGGAAGCGCGAGACCAGGCGCTCCCGGTTCCTCGACCGCCTCTCCAAGTCCTGCCCCTGGGACGCCTGGCTCGCCCTCGTGAGGGAGGCCCGCGGGGCCGACGCCGGGGCGAGGGGGGCCGGCCCCGCGATGGGCAGGCCGAGGGTCGACGACCTCGTGCTGCTGCGCATGTACATGGTGCAGGTCTGCTTCGGCCTCTCCGACCGCGAGTGCGAGGACCAGGTCTGGGACTCCGCGACGATGCGCTCCTTCGTCGGCGTGGCGCCCTTCGAGGTCCCCGACGCCACGACCCTGTGCAAGTTTCGCCACCTGCTCGAGCGCTGCGGGGTCGGCGAGGCCATGGTCTCCTCGGCCTTCGGGTCCGCCGCGGACGGAGGGCTCGCCGTGAGCCGGGGCACCATCGTGGACGCCACCTTCATCGAGAGCCCGTCGTCGACGAGGAACGCCGACGGCGCGCGGGATCCCGACGCCCACCAGGCCAAGAAGGGGCAGAACTGGCACTTCGGGTACAAGCTCGGGGTGGGCGTGGACGCCGAGACGGGCGTGCCGCACTCGGTGCGCATGGACGCCGCGAACGTCCACGACCTCGACCAGGTCCCCGACCTCGTGCGCGAGGGTGACGAGCGCGTCTGGGCCGACGCCGGCTACGTCGGCGTCGGGAGGAGGCCGGAGGTCGCCGGCGACCCCTCCCTCTCCGGCGTCGAGTGGATCGTCGCCAAGAGGCGCTCGCAGGTCGGCGAGGACGACCTGGTCGCAGAGGCCGCCAAGTCGGCCGCCCGCAGTGTCGTCGAGCACGTCTTCCACTGGGTCAAGGACATATTCGGGCTGCGGAAGACGCGCTATAAGGGGCTCGCCAAGGTGTCCAACCAGGCCTTCGCCGCCGTCGCCGCAGCCGGCTGCATGATCGCGAGGCGGGGACGGCGGCTCTGCGGGCCGCCCCTCGCGCTGTCGGCGGAGAGGATAGCCCTGCAACGCGAGAGGCTCGAGGAGCGGCGACGGAGGGCGGAGGGTGGGGCGCCGGCCGCGGCATAGCCTACCGCTGGCCGTCCCGCCATGGTCTGGGAGGCTGCGGCATGGCCCCCGGAGACCGGCGTAGCCCGCTTGGGGGCGTTGGAGCCCTCCTCACGTCAAAAATCACCCATGCTGGTCCCGAAGGGACGGGATCGGCGACTTTATCATCGCTTTCCTAGCGCATCGTACAGGCTGGCCCCCGCCGGCATACCTACTTTGGACCCCCTCGCGTCGACCGATTCCCTCAGTTCACCTTCGCCTTCGACGAGGCCCCTTCCGAGAGCGTCCGCGAGCACGTTCGCAACCAAGCTCAGATCCTCCCCAGAGTCGATCAGGTCGACCACCGTGCGCCCGGGCTTCGTCGCGGGGACGCCAGAGACGATTGCTACGTCCTTCGGGTCGAGCCGACGCTTCCTGAGGATCAGGTTGGGGCGCTTGGTCTGCTTTCTTTCGGGGGTGCAGAACTCGTAGGGCGAAGGGCCGATCTCGCCGATCCCGTAGAGCCACGCCGCCGTTGCTCCCATGGCGACGGGCGCGCTTTCGGCCGAGATGTCGCCAGGGCGCCTCCTCGGGTCGATCGACAGCCATGCCGCCAGGACGTCTTCCTCCCGCACGCTCGGCGAACCGCCCATGCGGTAGACACCCTTCGCGAGCCTCTCTATGTTGCCGAATCTCTCCAGCCTCGAGAGCGTGTATCGCTCGACGCCCAGCACCCCCGCCTGCGCAGTGGTGAAGAGCCCCCTTTGGGAAGAGGCAATGTCATTGATGGCTCGTATGGCTTCGATCGTTTTCATGCTTGCATTGTAGCATATTATGCTACAATGCAAGCATGTTGTTTGAGGAGATGCTATCGCGTACCTGCAAGTGAATAGTCACAGGTGGTTGGCATCTGCACTGAACGCTGCGCAGTCGCAGGTCGGTAGCTCGATCTCGGTTTAGGGATGAGGAAAAAGGCCCACGACGTCGATTTGAGGGCGCAAGGCGGGTCAAATCTCGTCCACGGGTCCATTCTAGATGAACTCAAGCTATGAATAACTGCAGGTCAGCTGGTAAAGTTGTAACCTGCAAGCCACCTCTGCTCTACTCCCACTCGATTGTCACATCGGCCATCTCCGTGTAGTCAGCGTGCCGTCTGGCCTGCGATTCCCATCACTCTTCCACCTGAAAAAGCGTGTAGCCACCGTGTAGTCGGGGGTGACTACACTGGATGCAGTCACTTCAAGAGGCTTTTCGGGGATTTGCGTAAGCTGACGCCCCGGTGAAGACGCCAACCTAGCGGCACTACCGCTCGCATGGGCCTGTTTTCTCCCACCAAGGGAAGAACGGCCACCGAGGAGGCGCCACCATGCCAGACAGCGTGCCCGAGGAGGCCCTGGGGCCGGGCCGCTCAGTGACCGGGGGCGCGGGGGCCGAGGGAGGCCCCGCGATCGCCTCGGCGAGGCCCCGGAGGCGCGCGCCGAGGCGTCCGGTGTGCGGCAGACGCTGCGAGGGCTACGACCGGCTGGCGACGCGAGGGCGGTTAGGGGGCCCGGGCTCCCGCTGCCCGAGAGGCCCGAGGACCTCACGGGGGGACAGGGGACGGCGCTCGCCGGCTCGCGCGGGCGCAGCCGCTGCCGGACGCCCGCGCTCGCGCGGCTGTCGCGCGAGGCGGGGCGAAAGCGGGAGGGCATCCTGAGGTCGACTGGGCTCGGGGTCCCAGACGCCCGCGCCTAGGCGGCGAGCGACAAGGCCAGGGTCGCGACCGGGCGGGGCTACGGGTCCCACGACATCGGCAACCTCATAGACCTCGTGATGCCCGGGTGCTCGGACCTGAGGCCAACGCTGCCGGGAGGGGCGGTGGTGACGCGATCTCTACCCACACGAACTCACGAAGCCTCAGATTTGGGGGTATTTTGACAACAACAACGTGTCGAGCACCTTCCGTCGCGGGCTATGGGCAAAAAAACTAGGGCAGGACCGCTTTCGCAACCCCGCCCCGCAAAACCCTAAGATTTTTTAGCTGGATACATTATGGACCGCCTAGATCCATCTGTCAAACACCCTGTTCAAGAAGGCCAGGGCGGAACGGAAATAGTCCGATCGGACATACCAGCCCGAACGCTCTTCTGATCTGGCGATGAAGGCGTCTACCAGTATACGGCACATCTCCCTGCTGTGGGTTCCTTTGATGAGCTCCCTGTAGGCGAAGGCCGTCATCGTTATCTGCTGGACCCTTGAGTTCGACATTTTCGAATGCCTCGCCCGCTTGTTCAGTCCGATTTCCGCAAGCGCGCGGGCGACCTCGTTCGGGGTCCGGACGTCGCTGGGCGCCCCGGGCGCGAAGCCGTTGACGATGGCCGTGGGCGCAGGCGTTTCTGACGGCCTTGACCTGCTTCAGCAGGTAGTGCTCCTTCCGCATTCCCCTATCGTCCCATTTGAGGGCACAAAAGCGGTAGAAGTCGATGAACCCGCCGAACGAGATGAGCTCGACGAACACCCATACGGGATAGGCACCGTCGTACCTGCGGACAAGGTTGCCGCTGTACCTGTCGTTCTCGAGGCGCCTTATCTCGCCATTGCGGATGTCCAGGCTCTTCTTCGGAAGGCTCGCCAGGTAGTCCGCGACGATCGAGTAGCCGTCCTCGCCTACCCGCTCGGTGACCTCACGCATGAGCTTGGCCTTGGCGAAGTGCTCGATGTCTAGCGTCATCGGCAGCAGCGTGTACCTAAGCATGTGGTCGATGGCCGCGAGGTCGCGCAGCTGCCCGAAGTCGAGCCCGACGTACTCCCCGTCACGCTCGCCTCCGACGCGCTTGTCGAAGAGCACGCGATAGGCCGCGAGCTTGAAGTAGTACGTCTTTTCGGAGAGTGTCTCGCGGGCGTCCTCCTCTGGGCACAGGTCGAACGTCACACCTTTGGACCTCAGGTGATCGATCTGCTCATCGACGGTGAGCTTGGGCTTCCTCGCTCGAATGCTAGCATCGTCACTGGTCATTTTCCCTCCTGTCCGTATCTGCACATTGTACGGCCACCGTCTCGGCAGACGGCGGCATGTAGGCTTCGCGCGCAGGGCTTCGGTACAGCGTGCTCTTGCTGATGCCGGTCGCCCCCGTGATCTCCGAGATGGTTTGCACCGGACGCCTTCTCGAGGTAGATGCGCTCGCATCCGGCGCTCTCGAGCGCGTCGACCTGACGATCGAGCCCCTGCCCCTCGGTCGACACCCGCGCATACCCGAATCTCATATCGCTCCTATCCTCGTTCCAAAAACGGCCGTTTTAGGGAATGTTCCGAGGTTGTCTGGGAACACCCCGAAAGGGCGTGCCGGTGGGTTCCCGAACCCGTCTGAGATAAGCATCTGAAATGCTGAAACGAAGGGTTGTGATGCACGGCCGAAATCACGCCGCAATGAACTGCAGCAGACCCTCTCCAACCTTCGCTAAGGGGTAAATTAGCCCTCGGAAGAATATTCGGTATGGCCGGCGGCAACATTGCTTGATAGCAAGCAACTGGGTTCAAAGTAAGAACCCATATCACCTATAGAGCTGTTTCAGCGCCTCTTCTTTGGATTCTATATCTCGGAGATAGGCAGTCCTGTCAATCTCCTGATCGTGGTGATCGCCTTTGCCAGAGATTTGATCCCATTGGTGACATCCATGGTTGATCCCTAAAACCCTGCAAGCGTGATCGGATTGCCGCTGCTACACACCGAGAGCCCTTACCGGCACCACCATCACGCCGTCCTCGCGACAATAGCTGAAGTCTCCCAAACCAACGAGCACCATGAGAAACGCCGGCGCGCCCATGCGCTTCTGATCAACCTTGTCTGCAAGCGTCTTGAGCGACTGCGCTCCCTGCGCGATGGCGGACTCGCCGCCGAGCTTAACTTCGATAAGGCCGTGGGAGCCATCGCGAAGATGGACTACGGCGTCGGCTTCAAGACCGGACTTGTCGCGGTAATGTGCCACCGAGCCGTCCATAGCGGATGCGTAAACCCGCAAGTCGCGGATACACATGCTCTCGAACAGGAGACCAAACGTGTTCAGATCAGCGACAAGGTCGGCTGGAGACGCTCCGAGTACCGCAGCTGCAATCGAGGGATCGACGAAGTGTCTCGTCGGAGAAGTGCGTATCGCCGTCTTGGAGCGCAGGTTCGGACTCCAAGCCTCGAGGTCTTCGATAACGAACAGTCTCCTCAAAGCCTCGATGTAGCCAAAGAAGGCACTCTCTCCCAGCGCAGCGGCGGAATCCATATCCTTGCGGACGGATTCGAGCGCACCCTGCGAGGAGCTGAGCCTTGCATAGGATCGAAGCAACGCGCGCGCAGAGGCTTCGCTTCTGTTGACGCCATCGACGCGACTTATATCAACGTCGATAATAGCGTCAACATAGTCGAGTGCCTGCTGTAAGGCGACGTTCCGATCCTGTCCGACCGCTTTCGGCCAACCTCCCCGGCAGACAAGGAAGGCCAGGTCTTCTATGGTGCCCACCTGCGCCCGAGCAGTCGGCCGTTCACCCGCGAACATGCCCTTAAGTGAAACCGAGCCCGACGAGTCTCGCGACTCGAGCAGCGACATCGGCCGCATGCGCAACCTGGCGATCCTCCCGGTGCCGGAGTGGGCCATCTTGCGAACATCGACTGGCACGCTCGAACCAGTCAGGATGAATTGACCGAACTTGTCGCGCCGATCAACTTCGAAACGAATCGCATCCCACAGAGAAGGTGCATCCTGCCATTCGTCGATGAGACGCGGTGCGTCACCGTCGAGAAGTAGCTGGGGGCTAAGCTCCGCCATGCGCATGTTCTGCTCGCGCGTTTCGGGAGCCTGCATATACAAGACGCTTCGCGCTTGCTGGACGCACGTGGTTGTCTTGCCGCACCATTTCGGACCCTCAACGAGCACGGCCCCTTTTGAACGCAAACGGAAAGCTAGAAGCTCGTCGCATACTCTAGGAAGGTATTCTTTCACAGCGTTCACAAAAAACCTTTTCATCAGCATAAACACGGTAGTTGGTCATATTTTACCACGGTAGTTGGCTACTTTTTATCAAGACAGTTGGCTATATCCTGCCACGGTAGTTGACCGCCTTGCGGTTTAGGATGGTAGCAGTCTTTCATCCCAGAGATTAATTAAAGCGATTTATACTGGATAGCTTGACAACCAACCTGACTGACACTCATCGCTTCACCGTATGGCATAGACATTGTAAAAGACAGATATGTAGGCCCCCGTCTAGGAGAAACCAAGAAAGTTAAAACCGATTGTGTACAATGGGGCCTCAGGCGCTGAGATATGAACTGCATCTATGCGTACATGCCAAACAATAATGTCCGATATAAGAGCGATTGCTGTAAGTTATAGTAGCAGGCAGGCGGCTCATACGTTCCAAAACTCTTCGAAGGCGGTATTGAGATATGGAGATGTATCACGAAAGGCCGAGAGGGGATGAGATGTATGCGTTTCTCGTCTGGGGCGTCCAAATGTTTTGCCTTTATATCGCGGGCAAATTTGCCGATAACTTGCTTGTCTATTGGTGCACCGGCGTTATCGCGCCGGGGTTGGCGATACTCATCTCTCTGAAGCATGATCACAGCTTGAAGGAGCTCGGGTTGTACCCAAATCATCTGAAGCGAGACTCGGCTGTCATGCTATGCGCCTTCGCAGCAGAACTGCTAATTGGCGTGTACATATACGGGATGTCCTTGGAATACGCACTGCCAGCTATCGCCTATTACATCGTCTGGATTGCAGTTCCGGAAGAAATCCTCTTTAGGGGGCTTATACAAAGCCACCTTTTTTCGCTTCCCGTCAACCGAAAACTCGTCTACTGCATGGGCGCCGCCCTGTTCGCGGCATCGCATATTCCCTATCAAATGCAGATCAGGACATGGGATGCGCTGTTTACCGTACAGCTTGGTATAACCTTCGTCACACATCTCGTTCTATGCTGGATTGTCAGAAAGAGAGGCAACATGTGCCTCCCCTTGGCGATTCACGTAGCTCAAGACTTCCTGCAGGTGATATAAGGGGCGGACACGGATCCCGTCGCCCTCCATGGCTCTACGTCACCACCCATCGGCAACGCTGTGACAACACTGGCCTCTTAGATGGTAGGCGAAGTCGCCTGCATTCCTTTTGAGACCGGACATCATGGGCATCTCTTCTTATGAAGGCACCCGTGGCATTTGCAAATCCACTCGGATTGGCTCTCTCGCAACAACTGTACGCATCCCGTCCAAATTCAGGGTCCTGGAACCCGGCACCGAGTTCCAGGTGAGCGCGCAGTAAAGATCCCCCGGCGTAGCCGGGGGCTTTAGTAACGCCCCATAGGGGCCCGTCACGACAGCGGCATTGCCGCGACGGGCCGGTGGCCGCTGCCGCCGGGCCCCCGTCGGGGGCACTCCCGCTACCCTGTGCGACTCCCGTCGGACTGCCGCCGGACGTGCCTCCCGGTGACCGACTCGCCGGGGCCGACGGTGCCCGCGTGGTGGCCCCTCGCCCACGTCGTCCGGTCCCTGCCCGTAAGGGCCCCCCGCTCATGGTGCCGCTCGCGCGGCATGACCGCGCTCTTACCCCTCGACCTACCCACCACGTCGCCCGCGCCGCGCTTGGGCACAATCCGGAGGCAGATGCGTGTGTGGTCGGGGTAGGCGCTCCCCTCCACCATCCCGGCGCCGGCCGGCATCCCGAGTATCTCGCCGACCTCCCTCCTGGTCTCGCCGCACAGCAC

Protein sequences of DBSCAN-SWA_8

>NZ_CP012069|2483033:2548095|2508424_2509258_+|WP_050344543.1|DBSCAN-SWA
MAVAHQKLEDLKDYLCELGSVAVAFSGGVDSTFLMKVAQNTLEDHALAVTARLKSFPERECTEAIDFCHKEGIRHIAVIFDELSIPGFSENPPERCYLCKRALFTRLMEDVRKRGFSHLCEGSNMDDEGDYRPGLKAVAELGVKSPLRHAQLHKAEIRALSHEMDLPTWDKPSFACLSSRFPYGEEITDEKLEMVGKAERLLLDLGFRQERVRIHGGGDHNSIARIEVPPSSLQRLLDERERVSEALRSYGFAYVTMDLMGYRTGSMNEILSQDGRA
>NZ_CP012069|2483033:2548095|2500675_2501542_+|WP_050341353.1|DBSCAN-SWA
MILEESYRLNNGVEIPKLALGTWLIDDDKVADAVRSAVEIGYRHVDSAQAYGNERGVGEGVRNCGVPREQLFVTSKVAAEHKTYSAAAASIDKTLRVTGLDYLDMMIIHSPQPWVEVNQSDDRHEAGNVEAYRALEDALAAGKLRAIGVSNFLEGDLQNILNHCEVKPAVDQLLAHIGNTPFELAAFCENNDILVEAYSPIAHGEADKIGAIVKMAERYDVSVAQLCIRYVLQLGMVALPKTANLEHMRSNADVDFEISAQDMETLRGVERISDYGDSSFFPVFGGKL
>NZ_CP012069|2483033:2548095|2521136_2522963_-|WP_050341384.1|DBSCAN-SWA
MLGLVHRILAFSGPYARRVRIAYVFAFLRALCATAPLMLAIMALRLLMAGQATPLSCCLLAAGMLVLLLLQSIFQYLADRLQSGTGYEIFADKRVELGQHLRRLPMGFFTAGNIGRISSILSADMVYIEEQSMSIVANVMSDVFSQVILTVFLFTMSPLVGVIVLVVELIAVLVAQPMLAQARRNSDVRQRTIERLTDSVLEYVEGLAVVKSYNLTGEGAQDLRDSFATTRDTSLRFACEQSPFEAALLALYGLGSAAVLALSVWQLEQGAMTPGTFVGIALFLFQLFGPLRDLYQQSTRLTIMESALNRIESLFSQDELEDAGTDDLPDAAAAAALGSHEIEFSHVSFSYGEKNVLRDVSLAADCGQMVALVGQSGSGKTTLANLLARFWDVSAGQVLLRGVDVRRLPLSALMAQISMVFQNVYLFQDTVFNNIAMGRPGATREEVYEAARKACCLDFVMRMPYGFDTMVGEGGASLSGGEAQRVSIARAILKDAPIVVLDEATASIDADNERHIQQAMTELCRGKTTLVIAHKLPTIQNADRIAVVGDGQVLECGSHDELMALDGVYRRMVQAGERACGWDVAPVQGGAQPDDSRCGDGRGEEARR
>NZ_CP012069|2483033:2548095|2522956_2526310_-|WP_050341386.1|DBSCAN-SWA
MIRFDDVSFHYGGESGTGDGVDHIDLTIADGAFTVLVGESGCGKTTLTRLINGLAPNFYEGEMEGAVYVDDICTTTAELHDTAALIGSVFQNPKSQFFNVDTTGELVFGCENQALSRDEMRRRLDRTRIDMQLDALMDRNIFELSGGEKQQIACGSVYASGPHVFVMDEPSANLDKKAIRRLHNILAKMKDEGKTIVLSEHRLHYLMDLADEFVYVKDGRIERTFSTQELRLLDDARLSELGLRCTDLRRLVRVRATSPAGGGPDGNGGKGQDGPYDDAYADARTVGRPALEAVDLSCSRGSARILDVDRIAFPVHSVVAVIGDNGCGKSTLAESLCGIIPSDGTVAIGGTFETARTRSKRSFMVMQDVNRQLFADDVAEEVSLNASVSEEEVDRVLEGLGLLEYKDRHPASLSGGQKQRVAIASALCAGKDILFYDEPTSGLDRRGMERFGTLLRAMRDKVLCSLIITHDPELILQCCTHVLHVRDGRAVALYPLDDEGAARVRGYFLSPSDESTSKRRDRTGAVGKILRYAGEQRRSIALAATLMIVGALASVVPYLLIYGLIDAALSGGTVTLAAAAPAVAAIAVCEVVHAASYTVGLVLSHKAAFSTLENLRKFLQERLDGQSIGTVRDLGAGAVKKLFTDDIESIELLLAHMIPEGAANITVVAVVLLTTFAVDWQMALLTLIVVGLGVIVSRQMYSVGIDKMGSYFAATKRLNNTIVEYVEGMEVVRVFNRQADSGEKFERAVSGYRDQALGWYKICWPWMALYGSLFSSVVLYSLPFGVLMVLLGRMTLSSCVLVLCLSFGIGPLLLHCMAFIGAIPQVSFKIQVLEKALDQAPLKSGSAGFVGRGHRVVFEDVRFAYRDAEVLKGISFTADEGRMTALVGESGSGKSTIARLLVHHYDVASGSISIGGQHIDDMTQVALSEQISYVSQDLFLFDRSILENIRVGRPDATDEEVIEAAKRAQCDDFIRDLENDYNTNAGTAGRRLSGGQRQRIAFARAILKDAPIVVLDEATAFVDPENEQRMSRAIREIIAGKTVIVIAHKLRSIAGADKIIMLHQGRVLAEGTQGELLSSCPEYRALWDASEQVSGWTLRDGGRIDAQGAGGREALSC
>NZ_CP012069|2483033:2548095|2497060_2498152_+|WP_050341349.1|DBSCAN-SWA
MQAEVLRIIEGGLTGNKTKVLNYANTLADNLEQSGDARFAKRIRSTIAGKRSSIATLDGLAAKPVDQESRMNIVDVQTILPDDVDIVLGSFLKEEIDGVVAMRGKRDVLARHGIDAQNYLLLYGPPGCGKTSIARYVAAQTGLPLITARLDSLVSSLLGSTAKNIRKVFDYAAQQECVFLLDEFDVVAKRRDDENELGELKRVVNSLLQNIDDFGQGSILIAATNHPGLLDPAVWRRFNKVVEVPTPGRAELEEYAERFIQPHMATKFKKKLYSVLEGLSYSALSTATKNAFYSAALDGSENGFTTYQLAREAYTLTHHSLDDQEGYIRHLIEAGCTLREIHDKTSISMRKIQAISRSFKEGV
>NZ_CP012069|2483033:2548095|2536717_2537554_-|WP_050341402.1|DBSCAN-SWA
MTHVLRMDVYRLLKSRLFYIILIILLMITVLCAVIADTSIHASPADTTSSTSEQNSIVIIDDSSVSEHDANHSNKVDFICDVFSGNIVAMTMIVFAALFAGAYRRTGYEKNVVCSVRRRWYFVASNAVICLLVCVLTVSLLLGASALSNTLIIAGYADLPFGSISKLGRFAVSYCALLVCATYVMSCFIRLCKNHVIGIVVALVYGSGIVYGIVNLALAPLLGPSFRIEAFLPLGTMYGLSVSMPDQAFCRAIVIALIFGTLSVAIDVMASNKRDIPC
>NZ_CP012069|2483033:2548095|2503395_2504244_+|WP_050341357.1|DBSCAN-SWA
MINFKMNNGNTIPALGYGVFQMTGEEVRQHLPEAIELGFRHIDTANAYFNEVAVGEVVKASDIARDEFFVTTKLFPQDYPYDKCRRAIDETLARLGMDYVDLLLFHQPYGEYVDGWKAMEEAVRAGKVRAIGLSNFSEQKVRQILGVSTIKPSILQVEINPRWNQHPLKEALAAENLVYEGWYPLGHGDKELLSLPVFTTLAEKYGKSASQVILRWHIQEGNVVFPKTLNPQHMAENIDLFDFALTDKEMTEINALPQEPYYHVPDEAPAWVWGPNDYSKQR
>NZ_CP012069|2483033:2548095|2538866_2539136_-|WP_050341409.1|DBSCAN-SWA
MSLFSVRACEQGKRLPEEMPSDFGISDANAAFRHLLELAHLFGLRSVRSADVVVLAHAGCKKPINKPFRDWHFAWVELQENGDEAAYQN
>NZ_CP012069|2483033:2548095|2536213_2536420_+|WP_050341400.1|DBSCAN-SWA
MSYSELVKSNADETDIRSYLTGGKQVAVTFRIPENLRESAKEAAELRGMSFSAFMRACMMDELSKKVL
>NZ_CP012069|2483033:2548095|2527059_2527677_-|WP_050341389.1|DBSCAN-SWA
MAQESQVQAATKGGGKLNTKDLIYAGAFCALYIVAMLIVVMGSGIVLPILYFIAPLTVGTVCGTIYMLYVLKIHKFGAALILGILFILATGHLTWYSLAVVLGASLIAELMIFLGKYTSKKMYLLSYVFFNLTMAAPYLSFVFNLQDSLKVTQDYYGEARAKAYETLFGSGFYVFTIALALVGGAVGALVASRLVKKHFAKAGIV
>NZ_CP012069|2483033:2548095|2489271_2489427_+|WP_157051511.1|DBSCAN-SWA
MLYVGAYVYDLPGTGCQIWVKIYYKITADLNDPIVAKLSDGGVDILPPGGG
>NZ_CP012069|2483033:2548095|2534999_2536106_-|WP_050341398.1|DBSCAN-SWA
MSFKQLETLHPVLARIDELQERVDEAKAAQPDAYDRIMESWAIESTYNSNNIEGSTLSLSDTALLYGGVQVDGLEDDIRQAEGGFAALRFLRSVVPGCAPLSEALIKRAHELVFAEAKDLATRGVYRKVEVEITGTSFQPAPSTYVPERMADLVEMCANTNRHPAIVAALFHLEFESIHPFVNANGRTGRLISNYLLMSSGFEPVNIQAESRARYIAAIRAFQEGDDPYPFAAFFCVNLVERQEKVLSLLVAGAADADAQAHSEIGVFLRDSADSSNEMPGGTPSSSDNHAKSSDNGGKSSDNLSASERKALSHMEGMESVRSSEVADLLGMSQRGAQKLLNRLVDKGLASSFGANRNRRYSVEKEHR
>NZ_CP012069|2483033:2548095|2489433_2489976_+|WP_050341335.1|DBSCAN-SWA
MPKDYVAAYERIAREEHREHGLVELGGWDTEPVEALVAEIGADPALVEDREACRARVRALRDLYHGDRAFPSDCPSGRRLAEAARSYLGRWPYDREVQDAYFEAMVLSWRYGEAYDYYRELRKDPRARLYAVWRMSDLASSLYHEGFIGARERERLWAAARRHDINTRGDWLPPDVPPYG
>NZ_CP012069|2483033:2548095|2520951_2521140_-|WP_050341382.1|DBSCAN-SWA
MSEATQKMLGLVAIIISIFLLMGGLYLPADFVAEPTQTALVILGVMLLLGGNVVMVVAHNDE
>NZ_CP012069|2483033:2548095|2545064_2546333_-|WP_050344544.1|DBSCAN-SWA
MKEYLPRVCDELLAFRLRSKGAVLVEGPKWCGKTTTCVQQARSVLYMQAPETREQNMRMAELSPQLLLDGDAPRLIDEWQDAPSLWDAIRFEVDRRDKFGQFILTGSSVPVDVRKMAHSGTGRIARLRMRPMSLLESRDSSGSVSLKGMFAGERPTARAQVGTIEDLAFLVCRGGWPKAVGQDRNVALQQALDYVDAIIDVDISRVDGVNRSEASARALLRSYARLSSSQGALESVRKDMDSAAALGESAFFGYIEALRRLFVIEDLEAWSPNLRSKTAIRTSPTRHFVDPSIAAAVLGASPADLVADLNTFGLLFESMCIRDLRVYASAMDGSVAHYRDKSGLEADAVVHLRDGSHGLIEVKLGGESAIAQGAQSLKTLADKVDQKRMGAPAFLMVLVGLGDFSYCREDGVMVVPVRALGV
>NZ_CP012069|2483033:2548095|2487848_2488184_-|WP_050341331.1|DBSCAN-SWA
MKTGLLLLARRDYQINGRRNRLTILAVGISVLLISSVLALSESFYAKMLDEMKVSDANVLTIAFGSGANPLNYTYQSLYTERDISLVRQVKDVSNVTGVKGVGIESLVYGT
>NZ_CP012069|2483033:2548095|2546779_2547391_+|WP_050341419.1|protease|DBSCAN-SWA
MEMYHERPRGDEMYAFLVWGVQMFCLYIAGKFADNLLVYWCTGVIAPGLAILISLKHDHSLKELGLYPNHLKRDSAVMLCAFAAELLIGVYIYGMSLEYALPAIAYYIVWIAVPEEILFRGLIQSHLFSLPVNRKLVYCMGAALFAASHIPYQMQIRTWDALFTVQLGITFVTHLVLCWIVRKRGNMCLPLAIHVAQDFLQVI
>NZ_CP012069|2483033:2548095|2484616_2484895_+|WP_050341327.1|DBSCAN-SWA
MNVGQLIGYLKDYDEDEEVEVEVRFGEAGESRASTFDVTLLSRGEVGGGDESPWPTIGANVGLGTMTEAGLDLLIEHVKGIDRRLGYHRGGA
>NZ_CP012069|2483033:2548095|2504418_2505843_-|WP_050341360.1|DBSCAN-SWA
MLKRRAYEKLLSWKAEAPEKALLVDGARQVGKTFLIEQFARQEFADYVKVDFLRDAQAGSISGAQDVRSLVERLSLMVGHEIVSGKTLVFFDEVQEAQNLVTLSKYLVQDGRFRLVMSGSLLGVELRRVRSFPVGSLRIETMYPLDFEEFLWSQGATDSLITRLERHFTSLSPVEESLHDQLLQLFHLYVVVGGMPASVQRYIDSRNDLGAVRDTQRDLIELYRADISRYAGERALQVTSIYDDIPSQLDKENKRFKLRSLRKKATYERYANDFQWLVSARAALKTVNVTEPRSMLRRTEEPNRFKLYLSDTGMLMRRYPVPVSLAVIAGERDVNCGGIYENVVAQELASAGVALRYHRHSGRGEVDFIGETLQGKVLPIEVKSGKTYKRHVALNNLLSVEEFGIEKAFVVSEANVSTELRAGKPMHYIPLYLVPFLARMLVAEDIGAREELGRLGLSERSLVIPPPDLSRLSG
>NZ_CP012069|2483033:2548095|2511650_2512928_-|WP_050341369.1|DBSCAN-SWA
MLVKFPFGREKVELTLPDSTSVLESKAVEYVPKGSQEELVQEALEHPIGSARVCELAEGKKNIVIITSDHTRPVPSKVTLPLYLKEIRKNNPDCNITILIATGFHRPTTKEEMIDKFGEDLVKNEKFVIHESEKDEDMVHLGTLPSGGSLLINKLAVEADLLVSEGFIEPHFFAGFSGGRKSILPGIASQKTVFANHCSTFIASDKSRTGVLDGNLIHKDMLFAAEQAKLAFILNVAIDADKKVIAAFAGDPTEAHETGCKFVKDLSSVDGVDADIVITTNGGYPLDQNIYQSVKSMTAAEACCNKDGIIIEMSKCNDGHGGEGFYQTFKNAASAKEVEDMILKVKMEDTIADQWESQILARILSRHEVLYVADPSAKQILEDMHIRFVPTLQEALDIAVKEKGENAKIAVIPEGISVIVKPCSA
>NZ_CP012069|2483033:2548095|2537550_2538288_-|WP_050341404.1|DBSCAN-SWA
MSLAIVTKDIVKKYDGQNVLDKVSLSVLEGDIYGLVGRNGAGKTTFMKIVCGLSSPTSGSMSILGADPLTKGSESFSKIGSLIETPCFFPYMNATDNLMLKCICCGIDAPDKHIKELLELVGLQNVRNKHTRDFSLGMRQRLGLAMALIGNPELLVLDEPINGLDPQGIAEIRSLILKINRETGTTIVISSHILSELSKVATRYGILDCGKLVYENSREALEAECENKDMSFEDFYFQITQGDGR
>NZ_CP012069|2483033:2548095|2517994_2518510_-|WP_083443971.1|DBSCAN-SWA
MWGLSLSRACPVRPGHERTSVPDRRWAKHVTPLRPTSSLRRERTPDLLKGNLHVNLGSIMENVVAQELDAHGFKLHYFNAKRYGEVDFVVQDRRDVIPIEVKSGNDWASHPALDKLLKVSEWDLGHAYVLCKGNVRQSGAITYLPLYMSMFLEPRPHPETLPYEVDLSALG
>NZ_CP012069|2483033:2548095|2493063_2495622_-|WP_050341345.1|DBSCAN-SWA
MTHVHRPPTHIKVRGARVHNLKGVDVDVPLGQFVGIAGVSGSGKSSLALGVLYAEGSRRYMDALSTYTRRRLSQASRARVDEVLHVPAALALRQRPTVPGVRSTFGTATELLNHLRLLFSRVGTYRCPNWHEVPPSMAVALERPLVCPRCNVEFMGLGAEQLAFNSEGACPSCGGTGVTRVVDESKLVPDESLTIDEGAVAPWGNLMWDLMKQVCKAMGVRTDVPFSKLTPEERDIVFHGPAEKRHILYRAKKSETFAELDFTYYNAVRTVENALSKVKDEKGMRRVERYLKVGPCEDCAGTRLNGRARSVTIRGVTLAEVSALTLDGLAKWVADVPGSLPVELRPMAEAIVDGLREPLLRLQQLGLGYLSLDRASSTLSTGELQRVQLSRAVRNRTTGVLYVLDEPSIGLHPSNVDGLLKVVDDLLADGNTVVVVDHDVRVLGRADYLIEVGPASGADGGTIIAQGRVAEVGGDPASRIAPFLTGERRVRMRERAGAGSGATVREAVFEQGAIELVTRSIHTVRPLTLRIPKGKLTAVTGVSGSGKTTMVLESLIPALRAQLAGEGLPEHVVSVAAPGMRRVNLIDATPIGVNVRSTLATYSGVLDELRRSFAKTPDAERLGLRAGDFSYNTGTLRCPTCGGTGQISLDVQFLPDVDIPCPDCEGSRYASQAWEIKMPARHGVSGESEGLVSLPELMACTVSQALERLSGLRRVASRLRVLCELGLGYLTLGEATPALSGGEAQRLKLASEIGRHQDGALFVFDEPTIGLHPLDVETLLRVLQGLIGSGATVIVIEHDLDMIANADWVVDMGPGGGEEGGHIVCAGTPEDVAAEPRSVTGRYLAQELRAGG
>NZ_CP012069|2483033:2548095|2538435_2538609_-|WP_157051515.1|DBSCAN-SWA
MTGREIRSTGHISQRSTKLAGEAADKAGLTWGDVADMPGREACGLLFPAQGEARDAS
>NZ_CP012069|2483033:2548095|2540333_2541407_+|WP_050340811.1|transposase|DBSCAN-SWA
MAQLTFSDVEMGMGRKRETRRSRFLDRLSKSCPWDAWLALVREARGADAGARGAGPAMGRPRVDDLVLLRMYMVQVCFGLSDRECEDQVWDSATMRSFVGVAPFEVPDATTLCKFRHLLERCGVGEAMVSSAFGSAADGGLAVSRGTIVDATFIESPSSTRNADGARDPDAHQAKKGQNWHFGYKLGVGVDAETGVPHSVRMDAANVHDLDQVPDLVREGDERVWADAGYVGVGRRPEVAGDPSLSGVEWIVAKRRSQVGEDDLVAEAAKSAARSVVEHVFHWVKDIFGLRKTRYKGLAKVSNQAFAAVAAAGCMIARRGRRLCGPPLALSAERIALQRERLEERRRRAEGGAPAAA
>NZ_CP012069|2483033:2548095|2541550_2542180_-|WP_050341413.1|DBSCAN-SWA
MKTIEAIRAINDIASSQRGLFTTAQAGVLGVERYTLSRLERFGNIERLAKGVYRMGGSPSVREEDVLAAWLSIDPRRRPGDISAESAPVAMGATAAWLYGIGEIGPSPYEFCTPERKQTKRPNLILRKRRLDPKDVAIVSGVPATKPGRTVVDLIDSGEDLSLVANVLADALGRGLVEGEGELRESVDARGSKVGMPAGASLYDALGKR
>NZ_CP012069|2483033:2548095|2526306_2527059_-|WP_050341387.1|DBSCAN-SWA
MEFELYGDDSGARIRFDPRTKLLVFFVSCFLSLSMHGNLPILVVGTLQCVMLTLSGKQALALKCLASLYVILFIRYCIEASGEQGAEAVVSVCMGLISLFVFFFPIMVSFLLLVRTTRVSQFLSAFQAMHLPMTLVIPLAVLFRFIPTVQDEWSGVRKAMAFRGISMTPGAIIRHPLLTIEYILVPLLFSSVGVMEELAAASLARGMDSTRKRSSFEDIQLGGADLIAISLFIIVAAWILAFRASGMSSL
>NZ_CP012069|2483033:2548095|2510049_2511429_+|WP_050341367.1|DBSCAN-SWA
MGKTLYLECESGISGDMVVGALLDLGANQERLLAALESLPMDGFSVQITRRAVSAIDVCDFDVVLDEGHQNHDHDMAYLYGGLDEAESHSHEHHHEHHGHGEGHHHHAHHEHGHGGGHHHEHRHLSDIERIINSGKLTPRARELAKRIFSILAEAESKAHGVGADEVHFHEAGAVDSIVDVVAAAVCLDDLDITHAIVGPLAEGHGRVRTQHGVLPVPVPAVVNIAASCGLVLAQRAMEGEFVTPTGAAIAAAIRTAEELPAAYVIRAVGTGSGKRAYKPVSTLRGMIIEPRGTTATESQPDAHTTTDAAPSRLWKLETEVDDCTGEALGHALERLFEVGVREAHYVPVFMKKSRPAYQVEVLCDESLLEAVERVLFEETTTIGVRRHRIERTTLSRREQTMETPLGPARVKLVTLPNGSERPYPEHDSIASLAKEKGVSYQEAFRTTLLIAEERDARS
>NZ_CP012069|2483033:2548095|2513914_2514679_+|WP_050341371.1|DBSCAN-SWA
MKFSDYIGRHHVFTTPSLLGAMDSPAAAEEQLRLAVRSGAVERVRRGLLVSNRGRFEDVPVDQFEVVAALDASAVVSYHSALEAHGVAHNAGFVCRFRSDTVRAGFDFRGVAYRPCGPVRNVRSKTLRSSWGPYLATTREQTVIDCLGKPALAGGVEETVRSLTAFVYLGVEELVGLASEAGPSMASRVGWLLSEKGDEWHVDEGDLARLESALGLGPYRLGYAADGAPTGWSAKWKLILPENREEMESWITRS
>NZ_CP012069|2483033:2548095|2484947_2485865_-|WP_050341329.1|DBSCAN-SWA
MKTGLLLLARRDYQINGRRNRLTILAVGISVLLISSVLALSESFYAKMLDEMKVSDANVLTIAFGSGANPLNYTYQSLYTERDISLVRQVKDVSNVTGVKGVGIESLVYGNSKRILASTLKGVSADFFTNFNIGYSGSFPNTDEEVLIGASVASASDLKIGDRLVATVKGEKRELRVSGILDRQEEQLFSTFPAEVNQLVATNVSNPLFAGSDYMYLSAIANDTSRLSEISAEIEGKLGEDDDLTAALQNTGLRPLVATRQNVLDMLGTWFGYISLFIYAVAALIGIICTIGTAVGILDRDSLDR
>NZ_CP012069|2483033:2548095|2507276_2508134_-|WP_050341364.1|DBSCAN-SWA
MTPVWGQQWGVGATVAEGSVLDGRDYWNKRAATFAQGSDGTYESRLLGLLALEPGQTVLDMGCATGTLAVPLGRRGHAVHACDFAERMLKVLGRVVADEGLPVTAHLLAWEDDWAAEGLGENCVDAAIASRSLGSRSMRERLRRLDGVARHKAAITVSAGVTPSRDPRLLALLGREVDERPERVSDAVGILCDLGRLPVVAYLPTLRPMTFATLDDGLAELRKMVVSEPLDGRERTLLDAFAAEHLERVWHVGAGGEASEGWRLDYSLPVVWAFIGWRTDGEVWT
>NZ_CP012069|2483033:2548095|2533865_2534588_-|WP_083443973.1|DBSCAN-SWA
MCVDIGIENSLISSIKDTLDDRSGHGLDHVLRVRTLALLFADSEGADPDIVELASLLHDVDDYKLVGTNKSQELNNAKRFLENAGIGSKAYETILQIIRTIGFSKRLEGVRPSTIEGMVVSDADMCDAIGAEGILRVHKYGISRQIPFFNKLLVPEVNNLSADGYRNNSSKHSVQHFFDKLLRVPSMMLTETGRAEAKRRQAIMIDFLKELFREESSKDWSEFLASYLKNDPKVLPNVAL
>NZ_CP012069|2483033:2548095|2544356_2544608_-|WP_050341417.1|DBSCAN-SWA
MRFGYARVSTEGQGLDRQVDALESAGCERIYLEKASGANHLGDHGGDRHQQEHAVPKPCARSLHAAVCRDGGRTMCRYGQEGK
>NZ_CP012069|2483033:2548095|2514660_2515608_+|WP_172674495.1|DBSCAN-SWA
MDNALVREFPPRALDKVERLLDLLAELGEHPFLKDKIALHGGTAINLFMLDAPRLSVDIDLSYVGALDRDEMLAERPIVVRSIDEVARSQGYPVFGARGGHAGRTFLLGYRSQWGPDHVKIDCIYMNRSPLMPIERRSPILRPELDVPLFTDAELAGGKVKAFFDRVKVRDLYDVANLKRVLDGRSAAERAVAHKAVLFYASLSASFPHGFEDRPGRFAGRGRELEEQLLPMLRRNEKAPTLDGLIGTAREFVSAYVLPQTDAEEEYLERFSQGLLVPDLLFEDEAMARAAAASPEVRWKLQNIRKMRGHGHGGA
>NZ_CP012069|2483033:2548095|2495780_2496872_+|WP_050341347.1|DBSCAN-SWA
MAERNPFTPAFGTVPPIMAGRDRLLAELHAALEQGVGDPNLSSILVGARGTGKTACLTRLCEDASDAGWVSASSSAIPGLLDDILQQAQRASAQLVKPKPQRQLTGLSVGPLGASWDMGDEERGNWRTRMSALLERLNARDVGLLITVDEVDASLSELITMAVVYQHFVRERRKVALLMAGLPSHVHALLNDKSVSFLRRAQRHPLGTIADADVRDALKRTVASGGKTIDEEALEICVEATGGFPYMLQLVGYRSWQSALGKAEVGKEDARAGMRAAQEDFKEHVLASTYRELSAVDLRFAKAMLPDKAESRLADIARRMGVTSRYASKYRGRLVAAGIVEELSRGVLRFAIPGFRKYLQEME
>NZ_CP012069|2483033:2548095|2528054_2528816_-|WP_050341391.1|protease|DBSCAN-SWA
MNENTDLLQPRSASSGDGDTHGGSGEPVAPMPHLALALSLRFVLILLMGVCLHLAGQSLLWTDLGIIVVDAITFATLAHLMRGEGRRLRDLYVPTGGADIAWGLLFSLIIIVGFFVSTVLANLIVYHGAPPAQPSSFVPPLWLGALALAVMPLTIAFAEEGLYRSYLLPRLARRMGQVPALLLVSVFFGLQHIGFAVPDGQQMLSRALTTLFAGLLFGGLWLWKRKTVPLVIGHWLLDFLFLGLPVFYMATSA
>NZ_CP012069|2483033:2548095|2488217_2488904_-|WP_050341333.1|DBSCAN-SWA
MIELVNVSKSFSDGAYKHVILRDASVTFPQGKISSIVGRSGLGKSTILKLIFGVESVDNGSILVDGTDVVSASPSVIRDLRRSTIGYVFQTFNLVNALTVEENILLPRFFSQHDTGMMGLDHLLKILDLPKSILGQNVSTISGGEKQRVAIARALINNPTVLLADEPTGNLDLNNERRVIELFRRINDEMGITIISVTHSHAVAEGADMLFSIIEGDVRQVSLDDFLV
>NZ_CP012069|2483033:2548095|2539275_2540190_-|WP_050341411.1|DBSCAN-SWA
MTYENGGQFDRALKKAIRNSGGDPGDGYRQALRDRFLCRVFSDPDERFILKGGSGLLARIPDGRATRDIDFVTASRESPEAALTALVALAGKDMGDFLTFKLDKWEESLDENGYSRLLKLRFQTFLGHEEKDPILVDLSLDCSITQPAERISPANRVCVEGLESCGYLVYPLPDQLADKLCAIMEMQPGGWPSSRMKDLVDVVYYSTNVTLLLKDLVRSIKCECSRRGMSVPRRFEAPAAWAGSFAAFAKKSGVPEKYAPFEAASSLASAFFDPALRGFFGHDASWDPESLRWRQEGSAETKER
>NZ_CP012069|2483033:2548095|2498155_2500486_+|WP_050341351.1|DBSCAN-SWA
MAEEFLPITVFRQREIDETRVEGMGNKDKPKWVLSGADLHEHAQSLIAGLSDAYEGVLHNEGLPYVYDVKLNERDTSKTKRKPIVDMLNVDGANGEANVIGMRGANSLIVRAKDAGQVRAMEERLSDKERYDLPLTCIESISRFVPEIKPTPDETVYKARLLDFGPDAALCERVFEDQLDFLCIAFQKVSYAQDLNVYRLEANQSQVKMIADGVASETLFFIRPMPRCVATLDGMPSVGAPDPMEPDLSMEYPVVGVLDSGIAPICQLQPWLMEKRLSTYTDNELDKQHGTFVAGVITYGDRFEHSEWVGGLPPKLLDGAVFPADGNIDESTMVDSIRTIVGATRDRVKVWNLSLSFMDEISDNEFSEFGMALDAIQDDHGVLICKSAGNCDVRADRTKGRLCVGSDSVRALTVGSAAQVKAPLDQAGVGEASPFSRKGPGPQYIIKPEVSHYGGNVGRTPTGYVRSEVHSFDVTGNPAGAVGTSFSTPRVSALAANLQLALAGEFDPLLIKALIVHSTSFPGDSLIPNTEKVEEMGFGIPVNLRSILSDEEHSSTLVLHGFLPRGQKVEINDFPMPSSLVRDGYYTGQVILTAAFSPIREPKEAAEYCQSDIEVKLGTYDHKELRDITKQGILNPIGRKDNKNLLNPSRYSRPKLRSAEDEFSRREKMLIRYKGKYAPVKKYALDLADLTKKNREAVRADRLWYLDMKGTYRDSVERRALQTNEPLRQEYCIIITIRDPNGLAPVYNEVPQLLEHKNFWHQNVQLANQVRAMVGQ
>NZ_CP012069|2483033:2548095|2516345_2517731_+|WP_050341374.1|DBSCAN-SWA
MEREAMSQLEAWMTSSRRKPLIVRGARQVGKTWLVREFAHRNFGALAHIVFLENEVMRAVFDGSLDPDRLLTAIGAYTGTNSLDGNTLVFLDEVQECPRALTALKMLCEQRPEVPVVAAGSLLGIALNRADDAQGNLARISWPVGKVEYLNMHPMTFREFLHAVGQGQLAELIRPDAIELVSAMGETYEDLLRSYLFTGGMPEAVQAYVDTRMLGAARNVQQRLLLDYEHDFAKHVRSASEAEHIRELWRSIPTQIARETGSNRFIYAQVKRGGRGRTYKDAVSWLTDSGLVTKVQRITRPNIPLRAYEDDSSFKLYLLDVGLLGAALHLDVRTILRGNELFTHAKGVYAEQYVCQQLVATDGIRPSATGSESQTTSMAPWYWSADGKRSKGEVDFLYECDGRVVPLEVKAGTSVKSGSIARFAKEHGITRSLRLSLKGYADQGWIVNYPLYAANLLPLVP
>NZ_CP012069|2483033:2548095|2501599_2502085_+|WP_050341355.1|DBSCAN-SWA
MSNILVAYFSATGTTKRAAKGLAEALGADTFEIVPQTPYTSTDLNWNDSTSRSTSEMNDEASRPPISGTVDGMASYNAVFVGFPIWWYTEPRIIDTFLESYDFSGKTIVPFATSGGSGLGKAPERMQRIATGSTVAAGRLLNGHQNPNELRDWAQRLGLMR
>NZ_CP012069|2483033:2548095|2483033_2484620_+|WP_050341325.1|transposase|DBSCAN-SWA
MYSQERRRLAIETFIKFDHSYADTIAELGYPTRSALRAWWNEYKRTGEVPASRFATNPKYTAEMRRRAVEHYLEHGKSLARTMRALGYPKSREKLCEWVDELAPGRRRHRGPRPRREAISLERKVRVVAELEARDGSAAEIAERHGVSRTAPYLWRREMMGDNGGEPERKGEPVSKRFDDLPDDVEVLQDMLREAKTQLRRVQLELDVRQATLEIVKKDPGADPELLTNAEKAAMATALRDKYKLCEILPAVGMAKSSYEYARNAQLRGETEEHAAARKAVVEAFEASGGTYGYRRITARVNAGSEPGGRVGEWTVRSIMGEEGLVARVARRRRRYSSYGGEISEAPPNLLRDERGRHDFGADAPNEKWVTDVTEFRIPAGKVYLSPIVDCFDGMPLSWSISTSPDAEMANSSLLGACEWLREGDRPTVHSDRGSHYRWPGWIGICEADGLVRSMSRKGCSPDNARCEGFFGRLKIEFFYGCDWSGVTIDEFMRMLDAYLRWYRDVRIKSDLDYRSPMQYRRDLGLAA
>NZ_CP012069|2483033:2548095|2547771_2548095_-|WP_050341421.1|transposase|DBSCAN-SWA
MLCGETRREVGEILGMPAGAGMVEGSAYPDHTRICLRIVPKRGAGDVVGRSRGKSAVMPRERHHERGALTGRDRTTWARGHHAGTVGPGESVTGRHVRRQSDGSRTG
>NZ_CP012069|2483033:2548095|2529847_2532418_+|WP_172674496.1|DBSCAN-SWA
MQFLTECFVLVMLVLAAYCVSELRMCRREIDALKDWVRNLNSRVEVEEMRARGDQRESAAAPPQYGGSEQGPPIPAAWPYANESDAPSPWPYEHGVSSPWPNANAPVAPASWPYESGASTPLSSAPERPPVPGRPPAPISSSGQPPVPPGMIPAAPATFAAMPEDRDLAERSDSLEGTFGRNVIGLAAVLLVFLGLVFLGILVIPTLGNEVRCALMWLLSLVLASAGLAAARRRVSAFSISLLGAGMGAIFISVLMTHVYFRYLGEVPAFGLMLAWMAACMVLVRRFESTALSVLVHMGMVISVCFSYSFGFSETRLPLVITYQTLSCTLVVAGSVLCLRRTYRYGLLVSLVLTLIASLFMRDYFGVGGMGSRDTSLSTPIAVAFFLQFAGASVLSLLLALSGKEEEERDVTTTLYAMGKLAWFGVLLVDVCAVARQLILQASGLSASTVPPGNDAARAVMLAEAHSTLIGIACLAAGVALILWLMRKRLVDAELGKLSLCLLGGMAAFLLLLRYLSTHLSLLPQPNLSYVVLVAVYFYVLAYAMHDSAYASIGDVTLGLDALLMLTSGYGELVERAGVGTAFTYVVMLTALAYLSWRIRSRVVEAFGGDVEAPRLRPRMLTCLAVAELSIHIIVNAAGYQHAQEIVAGILAVLLVGVYALQAWRRRVASGTFWMGAAVNELAVSALVSLWALTGDAAGLLPSRPNSPDTYAYVPSLIILMALVGLRLWDFLSERPRPTEALQVAEGIVFSLLGLALTQCSTAQMDIPFAAGIVVMMTALICIIVGFKALLRALRLYGLTIVIVCVFRLVLVDAAFLSPVARVVSFVIGGAICFAISALYSRAEQRIRGRVGEGGK
>NZ_CP012069|2483033:2548095|2492480_2493023_+|WP_050341343.1|DBSCAN-SWA
MPKDYVATYERIARKEHREHGAAIHGGWDTEPVEALVAEIEADPALVEDREACRARIRALRDLYHGDRAFPSDCPSGRRLAAAARSYLGRWPYDREVQDIHYLAMTLSWRYGEAYDYYRELRKDPRARLYAVWRMSDLASSLYHEGLIGARERERLYAAARRHGINTRGDWLPPDVPPYG
>NZ_CP012069|2483033:2548095|2518473_2519625_-|WP_050341378.1|DBSCAN-SWA
MPERQIYVNPFKPTAGMTPPVLVGRESVIDDFMDGLDEGPGAPGRLMRITGPRGSGKTVLLTALGNIATRRGWSVVNVSGKEALCASIQEQLVGDTRLRDLNVQISLPFVSAGAKIGDSGREPSFRDVFARATRSLSQDGAGLLITVDEAQDASRDDMAVIAANVQYMIREGQNVGLLFAGITTGVLDLLNGEGVTFLRRAQAEELASIPRADVARALRKTIEASGLAIEDAALAQAAADTCGYAYLIQLVGYYIWREGRRHVAESVTIDVEDVRRGTAAVRQYGQSMIETALAGLTKPALDYLLAMTEDNAASSTAAVARRMGKPAASANTYRRMLISRQVIEATAPGYVAFSMPFMREYLVKHEDDLLARYGASACQEPVR
>NZ_CP012069|2483033:2548095|2519751_2520711_-|WP_050341380.1|DBSCAN-SWA
MRAAVVFEAGGPEKLVVMEVPTPEVKPGWTLVRVRGFGINHSELFTRQGLSPSVRFPRILGIECVGGVAQTTDPDRLPQGQTVVSIMGEMGRAFDGGYAEYCLLPNEQVCPVEWDGDWATLAAIPETYYTAWLSLKNLRVESGNRLLVRGGTAGVGVAFSRLAHAARLSVTVCGTTRSVAKQERLLSAGFDDAVVDADGALQTDESFDRILELIGPKTLKDSCRHTTEGGIVCSTGLLGGKWYMDDDFSPIDDLPRNGYLTSAYSGNVSPSLMQELLDYIRERAVDVAPERVYTLDQVVDVHRYLESSHSFGKVVCVTG
>NZ_CP012069|2483033:2548095|2542856_2543099_+|WP_050341415.1|DBSCAN-SWA
MRQTLRGLRPAGDARAVRGPGLPLPERPEDLTGGQGTALAGSRGRSRCRTPALARLSREAGRKREGILRSTGLGVPDARA
>NZ_CP012069|2483033:2548095|2506361_2507243_+|WP_050341362.1|DBSCAN-SWA
MNTLARGMALAGALSAALARELRARTSKQRGGEAGEALRRVSTTYHENEFWVNVDGQNVYGLSYVPDVGGRLPLVILSHGLGSDHAIAGPYARELASHGIVTMTFDFRGGAETNRSDGTPRDMSVMTEAHDLEAVLAMARGWDCVDEGRIVIMGGSQGGAVTSIVAERAQPQVAGVVLLYPAFSIFDHVHRACSSLDEVPESNDLLGWLTVGSRYATDVWDYDFYQHMSYEGPVLIIHGSDDSVIPISYSRRAARTYRNCEYHTIRHGTHGFSGPAYDEAMSYLLDFVARVCA
>NZ_CP012069|2483033:2548095|2491219_2492203_+|WP_050341341.1|DBSCAN-SWA
MATRTKLDDYLALLGFDPEATYDVPENPADAALSGVAAFVRKHSAGQEPESTGIIHITGPSALGNSAPVKAVGNLLTSIQSTIDAVGASLMGNRSAEGSLPSAITSRTEMSLIASPMPGSVVIQVAPSLARMDDLYPEGLGLFDVEAELDAKPLADQAFIEFSTLISELREDDPDNSQFVDHLTDLGPRVATAMKSFCESVDKGVLDLELEWTESSRKAKTASISHSHAERAAKLIASANIENEEVAIEGVLLTVTQSTKDKLRILEDDGQEAVVMIGDIPPAATYPLHTGERVRIRAEKRVSRKLGGTRSEKLVGKAVELATKLEA
>NZ_CP012069|2483033:2548095|2492324_2492468_+|WP_157051512.1|DBSCAN-SWA
MILEYAYDLPGTGCRVWVKIYYWITADLSDPIRAKLSDGGVDILPPG
>NZ_CP012069|2483033:2548095|2509262_2510042_+|WP_050341366.1|DBSCAN-SWA
MERDELRALLRAVAAGQVDVDDACARVGEAPFVELGYAKPDVQRGVRQGVSEVIYGAGKTAEQIAGIMDALEQSGQRRIIVTRLDAKKGDELETLLKEEMPRLADGYRYLATPRMGILGEAPKPTGVGYVLVIAAGTSDLYCAEEAAVTAEMLGNEVRRVYDAGVAGIHRLLSHTGDIQRASVIIAVAGMEGALASVVGGLASCPVIACPTSVGYGASLGGISALLSMLNSCASGASVVNIDNGFGAGYQASLINHVGR
>NZ_CP012069|2483033:2548095|2490699_2491236_+|WP_050341339.1|DBSCAN-SWA
MIPELQEIGALRKVLPYGRYLTTMDELGETYAPTDNAVRRMIWDAFQEVTAVVRQAYGKLAATWIGGSFITSEEEPHDIDVVYLVDESSYSNGISDPRSQFVTQVLLRRSPITDKLNPLVDAYLFPVPPTTIDNNYNYSAARGYWDQFWSKTRYEEGNCRWLYPSAGYLEVMIDGYEN
>NZ_CP012069|2483033:2548095|2486059_2487820_+|WP_050340699.1|transposase|DBSCAN-SWA
MSYFLKQTRNKKGTYLQIYESTYDPGRGYGTHRSVRAVGYVHELEQSGIPDPVARLRAEVAAMNEEARASRAREGARLVGDSTPERHMGHFPVKALYRRLGIPADIGYLQMASGFRFSLDGLLESLVCARVVAPCSKSRTFHDVLPLLGEEPSFSLGQLYDGISYLGHEYRKVVEAANARVGELFGRDTSRSYFDCTNFYFEIDREDGLRRKGPSKERRADPIVGMGLLLDARCVPMGLEIYPGNESERPRIREVIGALKERHHMTGRTVRVADKGLNCADNVADAVLAGDGYLFSKSVRRLPARELAWVLSEEGWEDHLGRDGRIHHRTKSVTGDFEYRVSREGGGKGTVELRERRVVTFSPRLRSKQLREINRQVEKARRLRLAEARRSEYGDSAKYVTFVAVDSEGEVRDDERVVATLNRKAIGRARSLAGYNMLVTSEADMPEAEVYDTYHRLWRIEETFRVMKSELDARPVYLRRHDSIVGHFLICYVAVLLVRLLQVHVLGDEFGSGQLFGFMRGFRAVRVSERRYVNISRSSPVIDRLKEVTGLPLDHYHLTKGEYDRILGYRFPSLKATGQEESKGSI
>NZ_CP012069|2483033:2548095|2532661_2533036_+|WP_157051513.1|DBSCAN-SWA
MLNLYLNFYLRHQRAAATTCLLLGVFYAAGILCIDVLFTESTPNAARLLFVGCMLMGAVLFLISLFRARRDSSLWLPAHLCSMIGFGVGTGLAAGTTGAIACAMAAINGMCALAVLLLRVEQDS

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_050341325.1|2483033_2484620_+|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	2.5e-35	34.4
WP_050341327.1|2484616_2484895_+	hypothetical protein	NA	NA	NA	NA
WP_050341329.1|2484947_2485865_-	ABC transporter permease	NA	NA	NA	NA
WP_050340699.1|2486059_2487820_+|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_050341331.1|2487848_2488184_-	hypothetical protein	NA	NA	NA	NA
WP_050341333.1|2488217_2488904_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.0e-25	34.1
WP_157051511.1|2489271_2489427_+	hypothetical protein	NA	NA	NA	NA
WP_050341335.1|2489433_2489976_+	hypothetical protein	NA	NA	NA	NA
WP_050341339.1|2490699_2491236_+	hypothetical protein	NA	NA	NA	NA
WP_050341341.1|2491219_2492203_+	hypothetical protein	NA	NA	NA	NA
WP_157051512.1|2492324_2492468_+	hypothetical protein	NA	NA	NA	NA
WP_050341343.1|2492480_2493023_+	hypothetical protein	NA	NA	NA	NA
WP_050341345.1|2493063_2495622_-	excinuclease ABC subunit A	A0A1B1IVR3	uncultured_Mediterranean_phage	1.2e-108	33.2
WP_050341347.1|2495780_2496872_+	ATP-binding protein	NA	NA	NA	NA
WP_050341349.1|2497060_2498152_+	ATP-binding protein	R4TQL5	Phaeocystis_globosa_virus	5.7e-15	32.9
WP_050341351.1|2498155_2500486_+	S8 family peptidase	NA	NA	NA	NA
WP_050341353.1|2500675_2501542_+	aldo/keto reductase	A0A1V0SKP9	Klosneuvirus	1.2e-28	27.9
WP_050341355.1|2501599_2502085_+	flavodoxin	NA	NA	NA	NA
WP_050341357.1|2503395_2504244_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.1e-50	40.4
WP_050341360.1|2504418_2505843_-	ATP-binding protein	NA	NA	NA	NA
WP_050341362.1|2506361_2507243_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_050341364.1|2507276_2508134_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_050344543.1|2508424_2509258_+	ATP-dependent sacrificial sulfur transferase LarE	NA	NA	NA	NA
WP_050341366.1|2509262_2510042_+	nickel pincer cofactor biosynthesis protein LarB	A0A288TYA6	Enterococcus_phage	5.7e-17	32.1
WP_050341367.1|2510049_2511429_+	LarC family nickel insertion protein	NA	NA	NA	NA
WP_050341369.1|2511650_2512928_-	nickel-dependent lactate racemase	NA	NA	NA	NA
WP_050341371.1|2513914_2514679_+	hypothetical protein	NA	NA	NA	NA
WP_172674495.1|2514660_2515608_+	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_050341374.1|2516345_2517731_+	ATP-binding protein	NA	NA	NA	NA
WP_083443971.1|2517994_2518510_-	DUF4143 domain-containing protein	NA	NA	NA	NA
WP_050341378.1|2518473_2519625_-	ATP-binding protein	NA	NA	NA	NA
WP_050341380.1|2519751_2520711_-	zinc-binding dehydrogenase	NA	NA	NA	NA
WP_050341382.1|2520951_2521140_-	hypothetical protein	NA	NA	NA	NA
WP_050341384.1|2521136_2522963_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.9e-31	26.6
WP_050341386.1|2522956_2526310_-	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	5.6e-29	27.9
WP_050341387.1|2526306_2527059_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_050341389.1|2527059_2527677_-	MptD family putative ECF transporter S component	NA	NA	NA	NA
WP_050341391.1|2528054_2528816_-|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_172674496.1|2529847_2532418_+	DUF2339 domain-containing protein	NA	NA	NA	NA
WP_157051513.1|2532661_2533036_+	hypothetical protein	NA	NA	NA	NA
WP_083443973.1|2533865_2534588_-	HD domain-containing protein	NA	NA	NA	NA
WP_050341398.1|2534999_2536106_-	Fic family protein	D7RWK9	Brochothrix_phage	1.9e-05	21.5
WP_050341400.1|2536213_2536420_+	hypothetical protein	NA	NA	NA	NA
WP_050341402.1|2536717_2537554_-	ABC transporter permease	NA	NA	NA	NA
WP_050341404.1|2537550_2538288_-	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	1.4e-49	46.0
WP_157051515.1|2538435_2538609_-	hypothetical protein	NA	NA	NA	NA
WP_050341409.1|2538866_2539136_-	hypothetical protein	NA	NA	NA	NA
WP_050341411.1|2539275_2540190_-	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_050340811.1|2540333_2541407_+|transposase	IS5 family transposase	E5E3P6	Burkholderia_phage	5.2e-53	39.9
WP_050341413.1|2541550_2542180_-	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	NA	NA	NA	NA
WP_050341415.1|2542856_2543099_+	hypothetical protein	NA	NA	NA	NA
WP_050341417.1|2544356_2544608_-	recombinase family protein	NA	NA	NA	NA
WP_050344544.1|2545064_2546333_-	ATP-binding protein	NA	NA	NA	NA
WP_050341419.1|2546779_2547391_+|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_050341421.1|2547771_2548095_-|transposase	transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_9

Nucleotide sequences of DBSCAN-SWA_9

>NZ_CP012069|2839279:2845642|DBSCAN-SWA
GTCACTCCCACCTTCTGTCACGTCCCGTGACCTCGATGGCCTCGCAGGCGCCGGCCAACCTCGACGCCGTGCGCTTGCCGGGCATCCCGCCCCAGAGCGAGGCGAGCTGCCCTATCCGGTAGTTGCTGGTCACGATGGTCGGCAGGCCCGCCATCGTGCGGGCGTCTATCAGCTCCGCCAGGGTCTCGACGGCCCAGTCGGTCGGCCTCTCGACGCCGAGGTCGTCCAGGGCGAGCAGCCTGATCGTGCGGGCGCCCTCCAAGGCGCCTCGGATGCCGCCGTCATAGCCGGCCTTGACGTCGTCGAGGAGGCGCTTGGACGAGACGATCCTGGCGGCTACGGGGCGCAGCGGGTCCTGAGACTCCATCGCCATCCTCACGGCGCATGAGGCCGCCCAGGTCTTGCCCGTGCCCGGCTCGCCCCAGAGGTACGCGCCGCGACCCCCCTCGGCCATGGACCACACGCGCCGGCCGAGGTCGCTCTCCGCGTGCCGGTAGGCCCCCGTGAGCCCGGCCTTCCTCGCCTTCGACTCCATGATCGCCTCGATGATGGCCCTGACCTCGGGGTCATCCATCGAGACGACGCTAGAGCATGGCGTACTTCGCATCCACCTCACCACCCGTCACCATCTGCCCTGACCTGGGCCTCTCCCTGTTCGACCAGTTGCGGGCCGCAGCCCTCCAGTCGCGCATCCGGTTGCCGTTGCTCAGGCGCCAGCCCTGGGCCTCGAAGTAGTCCACGAAGCGGGCGGCGTCAACCCGAAGCGGGGGCTCGTGCGCCCTGCAGTACGCCTCCACCTCCTCGGCTGAGGGCGGGGAGAAGGCGGGCGGGCGCCTTGCGCGCGCCACACGCACTTCCTCTGGCTTGGTATGGATTGGTATGTATTGGTATGGATTGGGTTTCGCCTCCTCGGAAGCAGGCTCGACTTTGGTTTCGGGGGTCGGAAACCTGTCTGCGTCTAGGTTTTCTGACTCTGAAACCACATCCGCGTTCTGGTTTTCTGGGTCCGAAACCTTGTCGCTGTCCTGGTTTCCCGACTCCGAAATATCGTCGCCGTCCTGGTTTTCGGGGGCTGTGGGCACGTCATAGTCCGGTTTCGCCTCCTCGGAAGCAGGCTCGACTTTGGTTTCCTTCGGGGGCCTGCCGCCCCGTGCTCCGCGCGCCCGCATCTCCTTGGAGTTGTCGATGTCCTCGCGCAGTGACACGAAGATCGCGTCGAGCGGCCACTCAAGCTCCGGGACGGTGCCATACGTCCCGTACTCCACGAGAGCGAGCATGAGCTCGCCCCGGTACTCGGGCGGTACCCTCTCGCAGGTCTCGGTCAGCTTGGGAAACCAGGTGAACTTAGTGCCGCTCATGGCCCCTCCTTGTCGGTGTCTCTGTCAATGCCATCTAGCCGCCTCGGTCAGAACGGAATGCTCTCGTCGTACACGCCCTGAGCGGGCGGCGCGTAGGCTGGTGCCGCCTGCGGCCGTGGGGCCGCCTGCGTCGCCTGAGGCGCGTACGCCCGTCCCTGCGGGGCCTGCTGTTGCGCCTGGTTGGTCGGCTGCTGCTGCGGCGTGAGGAACACGACCTCGTCGGCGATGACCTCGAGCTTCGAGCGGTTCGTGCCCGTCTGCTTGTCCTGCCACTGGCTCCAGCGGAGCCTGCCCGAGACGGCGACCTTGGAGCCCTTGGCCAGTCGGGGCGCGATGGCGTCGGCCCGGCTGCCGAACACGACGACGTCCACCCAGTTGGCCCGGTCGCGCCACTCCCCGGTCTGCTGGTCCCTTTGAGTTGATCGACATTCCATCCTCCCTAGATTCATGTCATGATTGTTCTGATAATTTCCTCTTATCTGGCGCCCCATCTCGACGCGCCAGAGATTCGGCCCCTTACCTCGCGTTTCCCTGTCGCCCCAAGGACCGGGCCGAAGGTCCGTTGGCACACTTCTGGCAGTGCCCGTCACGGCCCGGCCGCCCTCCTGGCCGCCTCCTCGAAGGCGCGGGCGGCGGCGGCGTCGCGACCCGGCATCACGTGCGCGTAGATCCTGAGCGTGGTCGCCTCGTCGGCGTGCCCCAGTCGCTCCGACAGCGTCTTGAGGTCCACGCCGTGCGCGAGGCACCACGACGCGTGGGTGTGGCGCAGCGAGTGGAACGTCACGCCCGGCGGCAGGCCGAGGGCTCGCCGCATCCGCGAGAAGGAGCGCGACACGGCCGTGGGCCGCATGAGCGAGCCGTCGGCGGTGACCAGCGGGGCGTCGGGCCCCTGCCTGCCGAGGGCCCCGTCCTGCCCTTCCATCGCGGCGTCCAGGACGGCGACGTCGCCCTCGGTGAGCGCCACGTTCCTGCACCTCCTGCCCTTCGTCACGTCCCGCCTCCAGGGCGCCCTGCCAGGCTCCTCGATGACGGTCCCGCCCACGTGAAGGTATCGCGAGAGGCGCGACACGTCGCGCCTGCGCAGCGCGCACGCCTCGCCGACGCGCACGCCGGCGTGCAGGGCGAGCCAGGCGGCCAGCGCGCACGCCGCCCGGCGGCGGTCGCCTGGGCCCCCGCCGGCCTCCCGCATGGCCCCGTCGATGGCTCGGTGGACGCTGGCGAAGTCCCACTCCCCGAGCGCGGCGGCCTCGTGCCGCTCGGGCGACGGCTTGGCGGCGAGGACCATGGGGTTCGACTCGACCACGCCGACGCCCACGAGGTGGTTGTACGCGGCGCGCAGGTAGTTGTGCACGCAGAGCACGCTGTTCCTGCACAGCCCCTGCCCGCCCTCGCCCTTCGGCATGAGCAGCCTCTGCTCGAGGTCGCCCATGTCCGCGACCGTGAGGTCGCGGGCCAAGGCGCCACGGAGGTGGGCGCGCACGTAGCGGGCGAAGAGCCGCCAGGTCCGCACGCTGTTGGGGCTCGCGCCGTTGCGGGCCCTCATGTCGTTGTAGTCGTCGAGGAGGTCGGCGAGCCGGGCGCTCCTCACGGACCCGTCGGCGGTGAGGCTCGCCGCCCAGTCCTCGGCGAGCGCCTGGGCCTCCTCGCGCGACGACGCCTCCGCGAATGACCGGTAGGGCCTTATGGCCGAGCCGTCGCGCGCCTGGCCGAGGTACGGGCGGCACCACCAGGTGCCAGACGCGTCGGCATGGACCTCCACTCGCAAGGGGCTCACCTCACCAGGCGTCTCGTGCCCCTCAGACCGCATTGCCTGAGGAGGTCGACCACATGCTCCATCGTGGGACGGTCGAGCCCGCTGACCGTGACGGTCCATCCCGAGGGAACGGGCCTGGCGGAGCGCCCAGGACCTATGGGAACCCTGAGACCCATCTCGGCGGCCTCCTCCGGACTTACGGTGGTCATCGGGTCGATCTGCCTCCCTTCCGTCATCTTCCTTCTCCTCCCATCGCGTCCCTGACCTCCACGACCACGCGCGGCCAGTCGGGACACACTGCGAAGACGTGCCTTATGCCCGTGACGTGCGCCTGGTCGTCGCCTGCGATGACCTTGGCCATTACCAAGCCGTCGAGCACGAACTTCGCCGCGAACGCGACGTTGTCGAGGTCGCGCCTGGCGTCCCGCTCGTGCCACTCGCACGTGACCTCGACGGGTCCCTCGTGCCCGTGCGCCCCCGCCGCCCGCGCGTACCAGGCGACGAGCTCGGTCTGCTGGCGCTTGAGCCTGGATCCCCTCGACCAGTGGGAGCGGCAGGCCCTCGTGTACTCGTTGAGGCCCACGAGGCGGCCGGGGATGATGATCCGGTCCGTCATGACGCGACCATCGCCAGGACGAGCGTGACCAGCGCCACGATGACCAGGGCTGCCATCACCGGGGCGTCCGGCCGGTCTATGAGCATCCGAGCCACCTCCTCAGCTCGGCGTCGAGGACCCGCCAGCCCCTCTTGGCGCCACGGGGCGCCACCACCTTGAGGTCGCCGTCCCTGACGCTCCTGTAGAGCGTCCTCAGGGGCACGCGCGTCACCCTGGACGCCTCGGCGAGCGACCACGTGGCGAGCTCGCCGAGCCCCTCTCCCTGCGCAGCTGCTGTTGTCATTCCGTCTCCAATCCGTGTGTCTCGCGAGCGCCTGGGGCGCGCGGCCGGGTCAGGGAGGCCTCGGGGCCGAAAGGAGGTGCCCGCCGGCGCCAGTGACCGCCGGCGTCGCCCTTGCGGTCCGCCCCCGCGCTATGCGGGACGCGGTGCGGAGAGCCGGCCGCGCCTCCCGGGCGCTCGCGCTGGTTCGCTACATCTCGTACAGGTCCTCGACCTCGCACCCGACGGCCCTCGCGAGCGACGCGAGCGTCCCCAGGCTCGCCTGCGCGATGCCCTCGTCGGTCGTCCAGCGCCAGACGGAGGACTTGTCCACGCCGAGCCTCCTCGCGACCTCCTTCTGCCTCAGTCGCCTCTCGGCGAGCACGACCCTTAGCCTCGACCTCATCTCCCACCTCCAATCTCTGGTATCAGGAACTCAGGTTCTCGCAACATGCGGTATACTCCCTATGTCATGAGGAAGCGGAGGGAGGTGATCGCATGGCCAAGAACACGAAGCAGACCTCGCGCAAGGCGGCGAGCGCGGCGTCTAGGGTCTTGAGGGACGGCCGCACGGGCAAGGCGTCGAAGTCGGCGGCAGGGAGCGCCCTGTCCCAGACCCCGAGCCGGAGGAAGTAGGGACCCCGTCCCTGCCCGCGAGTGCCTGGTGCAGCCCGATCGCGAGCCCCTGCACCAGGTGCTCGTCCCCGTACAGGTCCGCGTACCCGAGCTGGTCGAGCAGCGCATGCACCAGCTCGTGGAGGAAGACCTGCTCCCTCTTCTCGGCCGACAGGCCCGACGACAGCCGTATGAGCTGCCTCGCCGGTGACACCGACCCGTCCTCGCCGTCCATGTCGGCGGTCTCGACCGCGTATGCCAGGCCGAGGACGCTCACGCTCCGTGGGACCTCGACCGCCATCAGCGGTCCCCCGCGATGCCGAAGTGCACGCAGGCCTCCTTCGCCTCCGCCACCCAGGCCTCGCGGGCGTGCGCCGCCACGAGCGCGTCGCACTCGTAGAGCGGTCCCCCGTAGCGCTCCCCGCGCGCGGAGTCCCACCCGTGCCCGGAGCGGTCCCCGGGCGTGTACATCCAAGGCGTGCCGTACTCCCGCACGCACGCCCTGCCCTCCTCGTCTGAGGAGAGCACGAAGTCGTGGTTTCCGTAGAGCTCGGGCTCTGGTTTGGCTGTCATTACTGGTTCCATTGCTAGTCCCTTCCTTGTCGTCTGCTAGTCGGTGGCCTCGTCGCGGGCGCCCTCGGGCACTGACCCGATCTGCTGCACTCGGTCCAGGTGCACGAGGCCGAAGACCTCCCTGGACCTTGCGACGGCCATCTCGGCGTCGATGTCATCCGCGTCCTCGTCCACGAAGCGGACCCCCAGCGGCGTCGAGTAGAACGCCCTAAATCTTGTGGTGGGCATGGGTAGGCTCCTTCATATGTTTGTTTAACTAACGTTCTCAGGTAAAAAAATATCCGCTATGTCACAGTGCAAGAAGCGACAGACGGCCTTTGCCTGCTCTATCGTCATCTTCTCTTGCTGCCCTTCATAGCGGCAGTATGTCTGACGTGATACTCCGAGGTATTCGGCGACCGCCCTCTGCTTGACGCCTCGTTCCTCCCGAGCTCTCTTGAGGGTCTGCATTTTCTCCTCCTCTCGACACTACGAATGATAGTTAAACAAACCTCGACTTGTCAAGCAAAGTTAGATAAAATGTTGCGAAAAGATGGCCCCGAGGAGATGAAATGTCTGTTTCCACAAACATAAGGAATCTGAGGGAGCAAAGCCGTATGACCCAAGGCGAGCTTGCGAACAAGCTCGGTGTTGCTCGATCCACCGTTACCCAATGGGAGAATGGCTGGTCAAGCCCTCGCATGGGAATGGTCCAGAAGCTCGCGACGTTCTTCGACGTCTCAACGGCCGACGTTGTGGCGGACGACATTCGGCCTGCAAATACCGTCGCGCCTATCCCGTCGTCGACCTCGGTCCCGCTGCGCGTCCTAGGCGTAACGTGCATGGGGGACGGCGATGAGGACGAGGCGGACAGGGCGGTGGAGGTGCCCGCGTTCGTGGTCGCAAACCACCCGAGGATGTTCGTAGTCCACGGAATCGGATCATGTATGGACAGGCGCTTTCCCGCCGATTCGGCGCTTGGGGTCGATCCGGAGATGGAGCCTCGCAACGACGACGCAGTACTCGTGAGGGACGGTGTGCGCGGGAGCTTCGTGCATGTCTACCTAAGAGGATCTGCCGGCACGGTGATGCTCTCGGCCGACAGCTGGTCGGAGTCACACGAGGACATCGTGATCGGCCCGGACGATCCGCCGGTCGAAATCCTCGGCGTGGTCGTATGGCATCAGGCGTATAGGGACGTTGTCAGATAG

Protein sequences of DBSCAN-SWA_9

>NZ_CP012069|2839279:2845642|2842621_2843005_-|WP_050341864.1|DBSCAN-SWA
MTDRIIIPGRLVGLNEYTRACRSHWSRGSRLKRQQTELVAWYARAAGAHGHEGPVEVTCEWHERDARRDLDNVAFAAKFVLDGLVMAKVIAGDDQAHVTGIRHVFAVCPDWPRVVVEVRDAMGGEGR
>NZ_CP012069|2839279:2845642|2843475_2843670_-|WP_050341868.1|DBSCAN-SWA
MRSRLRVVLAERRLRQKEVARRLGVDKSSVWRWTTDEGIAQASLGTLASLARAVGCEVEDLYEM
>NZ_CP012069|2839279:2845642|2845003_2845642_+|WP_083444014.1|DBSCAN-SWA
MSVSTNIRNLREQSRMTQGELANKLGVARSTVTQWENGWSSPRMGMVQKLATFFDVSTADVVADDIRPANTVAPIPSSTSVPLRVLGVTCMGDGDEDEADRAVEVPAFVVANHPRMFVVHGIGSCMDRRFPADSALGVDPEMEPRNDDAVLVRDGVRGSFVHVYLRGSAGTVMLSADSWSESHEDIVIGPDDPPVEILGVVVWHQAYRDVVR
>NZ_CP012069|2839279:2845642|2843811_2844180_-|WP_050341870.1|DBSCAN-SWA
MAVEVPRSVSVLGLAYAVETADMDGEDGSVSPARQLIRLSSGLSAEKREQVFLHELVHALLDQLGYADLYGDEHLVQGLAIGLHQALAGRDGVPTSSGSGSGTGRSLPPTSTPCPCGRPSRP
>NZ_CP012069|2839279:2845642|2841222_2842443_-|WP_172674507.1|integrase|DBSCAN-SWA
MRSEGHETPGEVSPLRVEVHADASGTWWCRPYLGQARDGSAIRPYRSFAEASSREEAQALAEDWAASLTADGSVRSARLADLLDDYNDMRARNGASPNSVRTWRLFARYVRAHLRGALARDLTVADMGDLEQRLLMPKGEGGQGLCRNSVLCVHNYLRAAYNHLVGVGVVESNPMVLAAKPSPERHEAAALGEWDFASVHRAIDGAMREAGGGPGDRRRAACALAAWLALHAGVRVGEACALRRRDVSRLSRYLHVGGTVIEEPGRAPWRRDVTKGRRCRNVALTEGDVAVLDAAMEGQDGALGRQGPDAPLVTADGSLMRPTAVSRSFSRMRRALGLPPGVTFHSLRHTHASWCLAHGVDLKTLSERLGHADEATTLRIYAHVMPGRDAAAARAFEEAARRAAGP
>NZ_CP012069|2839279:2845642|2839279_2839885_-|WP_050341854.1|DBSCAN-SWA
MRSTPCSSVVSMDDPEVRAIIEAIMESKARKAGLTGAYRHAESDLGRRVWSMAEGGRGAYLWGEPGTGKTWAASCAVRMAMESQDPLRPVAARIVSSKRLLDDVKAGYDGGIRGALEGARTIRLLALDDLGVERPTDWAVETLAELIDARTMAGLPTIVTSNYRIGQLASLWGGMPGKRTASRLAGACEAIEVTGRDRRWE
>NZ_CP012069|2839279:2845642|2844704_2844902_-|WP_050341875.1|DBSCAN-SWA
MQTLKRAREERGVKQRAVAEYLGVSRQTYCRYEGQQEKMTIEQAKAVCRFLHCDIADIFLPENVS
>NZ_CP012069|2839279:2845642|2844179_2844452_-|WP_050341871.1|DBSCAN-SWA
MTAKPEPELYGNHDFVLSSDEEGRACVREYGTPWMYTPGDRSGHGWDSARGERYGGPLYECDALVAAHAREAWVAEAKEACVHFGIAGDR
>NZ_CP012069|2839279:2845642|2844488_2844680_-|WP_050341873.1|DBSCAN-SWA
MPTTRFRAFYSTPLGVRFVDEDADDIDAEMAVARSREVFGLVHLDRVQQIGSVPEGARDEATD
>NZ_CP012069|2839279:2845642|2840683_2841070_-|WP_172674506.1|DBSCAN-SWA
MECRSTQRDQQTGEWRDRANWVDVVVFGSRADAIAPRLAKGSKVAVSGRLRWSQWQDKQTGTNRSKLEVIADEVVFLTPQQQPTNQAQQQAPQGRAYAPQATQAAPRPQAAPAYAPPAQGVYDESIPF
>NZ_CP012069|2839279:2845642|2839862_2840636_-|WP_050341856.1|DBSCAN-SWA
MSGTKFTWFPKLTETCERVPPEYRGELMLALVEYGTYGTVPELEWPLDAIFVSLREDIDNSKEMRARGARGGRPPKETKVEPASEEAKPDYDVPTAPENQDGDDISESGNQDSDKVSDPENQNADVVSESENLDADRFPTPETKVEPASEEAKPNPYQYIPIHTKPEEVRVARARRPPAFSPPSAEEVEAYCRAHEPPLRVDAARFVDYFEAQGWRLSNGNRMRDWRAAARNWSNRERPRSGQMVTGGEVDAKYAML
>NZ_CP012069|2839279:2845642|2842406_2842625_-|WP_050341862.1|DBSCAN-SWA
MTEGRQIDPMTTVSPEEAAEMGLRVPIGPGRSARPVPSGWTVTVSGLDRPTMEHVVDLLRQCGLRGTRRLVR
>NZ_CP012069|2839279:2845642|2843081_2843288_-|WP_050341866.1|DBSCAN-SWA
MTTAAAQGEGLGELATWSLAEASRVTRVPLRTLYRSVRDGDLKVVAPRGAKRGWRVLDAELRRWLGCS

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2837220:2837234	attL	NA	NA	NA	NA
WP_050341854.1|2839279_2839885_-	ATP-binding protein	A0A2H4J4P8	uncultured_Caudovirales_phage	2.4e-07	29.1
WP_050341856.1|2839862_2840636_-	hypothetical protein	NA	NA	NA	NA
WP_172674506.1|2840683_2841070_-	single-stranded DNA-binding protein	A0A1P8VVD7	Erythrobacter_phage	2.5e-05	39.1
WP_172674507.1|2841222_2842443_-|integrase	site-specific integrase	Q38608	Lactococcus_phage	6.4e-07	42.9
WP_050341862.1|2842406_2842625_-	hypothetical protein	NA	NA	NA	NA
WP_050341864.1|2842621_2843005_-	hypothetical protein	A0A0A7RTR1	Clostridium_phage	1.2e-15	35.9
WP_050341866.1|2843081_2843288_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_050341868.1|2843475_2843670_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_050341870.1|2843811_2844180_-	hypothetical protein	A0A1Q1PVT7	Staphylococcus_phage	4.0e-05	34.1
WP_050341871.1|2844179_2844452_-	hypothetical protein	NA	NA	NA	NA
WP_050341873.1|2844488_2844680_-	hypothetical protein	NA	NA	NA	NA
WP_050341875.1|2844704_2844902_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_083444014.1|2845003_2845642_+	helix-turn-helix domain-containing protein	A0A1W6JND9	Staphylococcus_phage	3.9e-08	23.9
2862703:2862717	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage
NZ_CP012069.2|WP_157051455.1|1880402_1881401_-|hypothetical-protein	1880402_1881401_-	332 aa aa	NA	NA	NA	1873337-1899481	yes

Protein sequences of NZ_CP012069.2|WP_157051455.1|1880402_1881401_-|hypothetical-protein

>NZ_CP012069.2|WP_157051455.1|1880402_1881401_-|hypothetical-protein
MRDMLREELQSTSGTESLAITFLDAEEDLPGEYEPGKYLVDKFGLRDDSLHYRSSRGSGQGYLLRRGVLRNKIVWIKGLGVDDAQVWERFCAGWNISTLDEGLFVIEDRTSETSVPQNLTIIDYAECVDEYSVQLFNGLTLNSQEFDSYKMVWKRYVAALMTSLCGSDVEVAHELVWSHDLRKEDAYVAITTMVDSGIFDSRGHGSFGHVLNVARRGDKATIDERIWAAQLEVLFPMIERERLLIVEKLSDSISPLIDGGRIEQHGDKLTSLEDVELGTLVYLMNCDQDGVRVLDVKEKGLRDRIFLLRKCRNHLAHHRCCGMDQVSQLLNS

Self-targetings in the prophage

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP012069_13	Orphan	13.1|687170|36|NZ_CP012069|CRISPRCasFinder	687170-687205	36	1890675-1890710	1
NZ_CP012069_14	Orphan	14.1|972710|38|NZ_CP012069|CRISPRCasFinder	972710-972747	38	1895309-1895272	2
NZ_CP012069_19	Orphan	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	1895274-1895308	1
NZ_CP012069_19	Orphan	19.1|1822501|35|NZ_CP012069|CRISPRCasFinder	1822501-1822535	35	1890709-1890675	2
NZ_CP012069_20	Orphan	20.1|1937505|38|NZ_CP012069|CRISPRCasFinder	1937505-1937542	38	1890711-1890674	0

1. spacer 13.1|687170|36|NZ_CP012069|CRISPRCasFinder matches to NZ_CP012069 position: 1890675-1890710, mismatch: 1

actatggaaaatggcccaactgggcaaacgcgcccg	CRISPR spacer
actatggaaaatggcccaactgggcaaacgcgctcg	Protospacer
*********************************.**

2. spacer 14.1|972710|38|NZ_CP012069|CRISPRCasFinder matches to NZ_CP012069 position: 1895309-1895272, mismatch: 2

cactatggaaaatggcccaactgggcaaatgcgtccga	CRISPR spacer
cactatggaaaatggctcaactgggcaaatgcgttcga	Protospacer
****************.*****************.***

3. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to NZ_CP012069 position: 1895274-1895308, mismatch: 1

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gaacgcatttgcccagttgagccattttccatagt	Protospacer
**.********************************

4. spacer 19.1|1822501|35|NZ_CP012069|CRISPRCasFinder matches to NZ_CP012069 position: 1890709-1890675, mismatch: 2

gagcgcatttgcccagttgagccattttccatagt	CRISPR spacer
gagcgcgtttgcccagttgggccattttccatagt	Protospacer
******.************.***************

5. spacer 20.1|1937505|38|NZ_CP012069|CRISPRCasFinder matches to NZ_CP012069 position: 1890711-1890674, mismatch: 0

tcgagcgcgtttgcccagttgggccattttccatagtg	CRISPR spacer
tcgagcgcgtttgcccagttgggccattttccatagtg	Protospacer
**************************************