CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP011125	Sandaracinus amylolyticus strain DSM 53668 chromosome, complete genome	43 crisprs	RT,csa3,DinG,DEDDh,cas3,WYL,cas4	9	10	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP011125_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_1

357193-357286

Orphan

Consensus_repeat	Method
GTGCGTGCCTGTCGACTCACCGCGCG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP011125_1

>merge|NZ_CP011125|1|357193-357286|CRISPRCasFinder
GTGCGTGCCTGTCGACTCACCGCGCGGACTTCTTCAGGAGAGCAGGAGAGTTCGGAAGACCACGTCGCGTGCGTGCCTGTCGACTCAACGCGCG

>NZ_CP011125|1|1|357193-357286|CRISPRCasFinder
GTGCGTGCCTGTCGACTCACCGCGCG	GACTTCTTCAGGAGAGCAGGAGAGTTCGGAAGACCACGTCGC
GTGCGTGCCTGTCGACTCAACGCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_157068589.1\|366629_366914_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230618.1\|352070_352367_+\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP011125.1\|WP_053230621.1\|353557_354502_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|143581
NZ_CP011125.1\|WP_053230628.1\|360179_361211_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187538
NZ_CP011125.1\|WP_053230634.1\|370077_371238_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230619.1\|352366_352972_+\|SdpI-family-protein	unknown	unknown	gnl\|CDD\|379303
NZ_CP011125.1\|WP_053230624.1\|356811_357147_+\|MGMT-family-protein	unknown	unknown	gnl\|CDD\|226219
NZ_CP011125.1\|WP_053230629.1\|361282_362230_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176109
NZ_CP011125.1\|WP_157068590.1\|366987_367503_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380345
NZ_CP011125.1\|WP_053230616.1\|351136_351598_-\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176909
NZ_CP011125.1\|WP_157068588.1\|358045_358684_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230615.1\|350423_351044_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|223340
NZ_CP011125.1\|WP_157068587.1\|355846_356779_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230620.1\|353090_353501_-\|tRNA-(N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase-TrmO	unknown	unknown	gnl\|CDD\|187753
NZ_CP011125.1\|WP_053230617.1\|351594_351963_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|223713
NZ_CP011125.1\|WP_053230622.1\|354872_355835_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP011125.1\|WP_053230633.1\|367729_370081_+\|response-regulator	unknown	unknown	gnl\|CDD\|237425
NZ_CP011125.1\|WP_075097423.1\|362254_366520_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053230627.1\|359220_360174_+\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230625.1\|357400_358003_-\|DUF2267-domain-containing-protein	unknown	unknown	gnl\|CDD\|378360

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053230618.1\|352070_352367_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	9.58036e-20
NZ_CP011125.1\|WP_053230621.1\|353557_354502_-\|hypothetical-protein	gnl\|CDD\|143581	cd07177, terB_like, tellurium resistance terB-like protein. This family consists of tellurium resistance terB proteins, N-terminal domain of heat shock DnaJ-like proteins, N-terminal domain of Mo-dependent nitrogenase-like proteins, C-terminal domain of ABC transporter ATP-binding proteins, C-terminal domain of serine/threonine protein kinase, and many hypothetical bacterial proteins. The function of this family is unknown.	0.000516227
NZ_CP011125.1\|WP_053230628.1\|360179_361211_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187538	cd05227, AR_SDR_e, aldehyde reductase, extended (e) SDRs. This subgroup contains aldehyde reductase of the extended SDR-type and related proteins. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.01971e-86
NZ_CP011125.1\|WP_053230619.1\|352366_352972_+\|SdpI-family-protein	gnl\|CDD\|379303	pfam13630, SdpI, SdpI/YfhL protein family. This family of proteins includes the SdpI and YfhL proteins from B. subtilis. The SdpI protein is a multipass integral membrane protein that protects toxin-producing cells from being killed. Killing is mediated by the exported toxic protein SdpC an extracellular protein that induces the synthesis of an immunity protein.	2.71298e-13
NZ_CP011125.1\|WP_053230624.1\|356811_357147_+\|MGMT-family-protein	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	2.26184e-21
NZ_CP011125.1\|WP_157068590.1\|366987_367503_-\|cupin-domain-containing-protein	gnl\|CDD\|380345	cd02215, cupin_QDO_N_C, quercetinase, N- and C-terminal cupin domains. This family contains quercetinase (also known as quercetin 2,3-dioxygenase, 2,3QD, QDO and YxaG; EC 1.13.11.24), a mononuclear copper-dependent dioxygenase that catalyzes the cleavage of the flavonol quercetin (5,7,3',4'-tetrahydroxyflavonol) heterocyclic ring to produce 2-protocatechuoyl-phloroglucinol carboxylic acid and carbon monoxide. Bacillus subtilis quercetin 2,3-dioxygenase (QDO) is a homodimer that shows oxygenase activity with several divalent metals such as Mn2+, Co2+, Fe2+, and Cu2+, although the preferred one appears to be Mn2+. The dioxygen binds to the metal ion of the Cu-QDO-quercetin complex, yielding a Cu2+-superoxo quercetin radical intermediate, which then forms a Cu2+-alkylperoxo complex which then evolves into endoperoxide intermediate that decomposes to the product. Quercetinase is a bicupin with two tandem cupin beta-barrel domains, both of which are included in this alignment model. The pirins, which also belong to the cupin domain family, have been shown to catalyze a reaction involving quercetin and may have a function similar to that of quercetinase.	1.31396e-26
NZ_CP011125.1\|WP_053230616.1\|351136_351598_-\|SRPBCC-domain-containing-protein	gnl\|CDD\|176909	cd08900, SRPBCC_CalC_Aha1-like_7, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	2.72699e-56
NZ_CP011125.1\|WP_053230629.1\|361282_362230_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176109	cd08417, PBP2_Nitroaromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of dinitrotoluene and similar compounds, such as DntR, NahR, and LinR. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. Also included are related LysR-type regulators clustered together in phylogenetic trees, including NodD, ToxR, LeuO, SyrM, TdcA, and PnbR. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.89351e-48
NZ_CP011125.1\|WP_053230615.1\|350423_351044_-\|dihydrofolate-reductase	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	3.59516e-22
NZ_CP011125.1\|WP_053230620.1\|353090_353501_-\|tRNA-(N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase-TrmO	gnl\|CDD\|187753	cd09281, UPF0066, Escherichia coli YaeB and related proteins. Uncharacterized protein family UPF0066. This domain includes Escherichia coli YeaB, Archeoglobus fulgidus AF0241, and Agrobacterium tumefaciens VirR. Proteins with this domain are probable S-adenosylmethionine-dependent methyltransferases but they have not been functionally characterized and the substrate is unknown.	2.33744e-45
NZ_CP011125.1\|WP_053230617.1\|351594_351963_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	8.45604e-13
NZ_CP011125.1\|WP_053230622.1\|354872_355835_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	7.17508e-29
NZ_CP011125.1\|WP_053230633.1\|367729_370081_+\|response-regulator	gnl\|CDD\|237425	PRK13557, PRK13557, histidine kinase; Provisional.	1.44582e-76
NZ_CP011125.1\|WP_075097423.1\|362254_366520_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.08144e-74
NZ_CP011125.1\|WP_053230625.1\|357400_358003_-\|DUF2267-domain-containing-protein	gnl\|CDD\|378360	pfam10025, DUF2267, Uncharacterized conserved protein (DUF2267). This domain, found in various hypothetical bacterial proteins, has no known function.	1.1652e-06

>NZ_CP011125.1|WP_053230624.1|356811_357147_+|MGMT-family-protein
MAKPRARDPEETPPFERVQALVKRIPRGRVATYGQLSRMIDGRLTPVGVGWAIRAASDAIPWQRVVGAKGRISTEREHPGLQREMLESEGVRFDDEGRVDLERHGWEPSVR
>NZ_CP011125.1|WP_157068587.1|355846_356779_-|hypothetical-protein
MRARFPRSARWLVCLLMPVAISCGPSTPALTRAETAEQLVAALGACVPVSLGGGQTLSGSFVGLVAQELLIGGPFYSFGPSFGMNHDQIVCVVRAGGDCERVRECLGFTIEVVETCELAPRCDEDAVTFCTGGGAFGEPRMRVRQACAVHDLVCVASTDGSPRCALGTCPPSDAIVTTCNGRSLTTCSGGVLTTGTCRAGSECSETAGTCVGAGAACTRETCEGDVFVPCEPISGRTAGPIDCAALGMRCRGFGTLGAGCVAPDDAECGSGGGSCRDGVIEYCGHDGVRRAYDCVAHGFEGCVSDRCVPR
>NZ_CP011125.1|WP_053230622.1|354872_355835_+|M23-family-metallopeptidase
MLEKIGLIEALGLLPLDRTAREARIALLGDGQTPKSRFDLSSLRQLQPRYSVPLWLGRAPHGRLVPITNLFNHRQPPPELGWSVRVTDVRDFRGGTNSYDSHNGTDFAVPPGTTVVAAAPATVLRISSEFHRGGRKVFLDHGRGLATSYNHLARFLVRPGQRVARGEPIAISGYSGIDALVGFPWTPPHVHFNVWLNGEYVDPFSCEGSTPALWRTGNAPVPSSDHHDHALEPTAWDERVLDAIVAACEHAPTRAELESAPTTIERAGAALMHLNYFPTRFGSRARALRASLYPTHFAREPRLDLPFARRDYDGVHFPDR
>NZ_CP011125.1|WP_053230621.1|353557_354502_-|hypothetical-protein
MQLSRVPEDVARAGLRALYTVCIADGELSALERAFLRGVQDHVLHSHVDLDALEPIATDALAAAIAPGAHRERVLAGAVIAACVDGRATDDEVDVLARLATALELDPAPVRTARRLAKRHLLLARVDIARRALAGHKVRQTVREEGVIAMVAQLMPMMGIADHALAARYRSLAASPAGTLGRAYFDFVESNGFSFPGEPGAGPEIIVVHDCLHVLGGYGTSPADEIEVASFQAGCHGGDPLYGLLFGLAQYHLGVQVAPVAPAESMHADPERMMRAFARGCRVERDMWSDFRPWDHFAKPLDALRAELNVLPTA
>NZ_CP011125.1|WP_053230620.1|353090_353501_-|tRNA-(N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase-TrmO
MNDDLTIHPVGIVRSGLRALADAPRQGDEGAPDAWIELDPRFVPASEGLAIGHEILVLTWLHRADRALLRVHPRDDTSRPLHGVFATRSADRPNPIGLHRVRIVEITNGRLRVAPLEAIDGTPVIDVKPILGPGER
>NZ_CP011125.1|WP_053230619.1|352366_352972_+|SdpI-family-protein
MSSMRSSWILGTVALVGSAVVYPWLPPEVPIHFDVTGHVDGTAPKAIGAFLLPVITLLTIAIVTWVHRRRPEHERAPIVATTLLSTALLTGLQTIILRAALLGVTDVAVALGTLLALASLGLALLLPRVRRNPVVGIRTPWTLASDEVWARSHRLGGYFFAAAGVIGLSAVLLGCPAVAVVALVAAAVAAGVGSWWIAREA
>NZ_CP011125.1|WP_053230618.1|352070_352367_+|helix-turn-helix-transcriptional-regulator
MKDTFSALSDPTRRAILRLLRRGSRTAGEIADEFELSKPTLSHHFRVLEAAGLVRSEKRGTSVVFTLQTNVLEDAAAELLELAGKTPAASSHKKKVRS
>NZ_CP011125.1|WP_053230617.1|351594_351963_-|helix-turn-helix-transcriptional-regulator
MLEQQAAVDRVFHALGDPARRAMIDRLSRGPASVSELAAPFSMTLAAVVQHVQVLEQSGVITTQKVGRVRTCQLAPEGLAAAERWIAERRSLCERRFDRLGAFLDEEEASPTPPTNKRKKKR
>NZ_CP011125.1|WP_053230616.1|351136_351598_-|SRPBCC-domain-containing-protein
MSEEATHHDVFTVERTYRAAPERVFDAWADPAKKRRWFAEGEGWTIESFELDFREGGLERTRFRFGDGPPMTNDTVFHDIVANRRVVYSYGMTMSGKRFSVSLATLVLERAGSGTRMRYTEQIVLFGQGREAVEQRRLGCGELLERLAAELGE
>NZ_CP011125.1|WP_053230615.1|350423_351044_-|dihydrofolate-reductase
MSKVFFSVTMSLDGFIAPEWRSDEQWLQQWLGLQDFVVHQKFFRENLKLGEGGETGVDNTHLERTFQRAGVSIMGKRMFDAGEHSWPEEAPFHTPVFVLTHKPRAPWERPGGTVFHFVNDGIESALRQARSVARDKDIRIAGGAQTIRQYLQAGLVDEFHVALAPVFLGEGIRLFDRMDPKKLSLSTTEAVHSPRVTHLRYAVKAR
>NZ_CP011125.1|WP_053230625.1|357400_358003_-|DUF2267-domain-containing-protein
MDDTTFRELARERLGPLGADEADRAIDVTLRVLAEACSRCLADHIAEALPPGAATIMRAVIGHELGGDASAIVARTARREGVRAALGIEHLSAVASVIGEHLDDETMRLAEAELDPSVVRLLQPRRFAPPPVAHHDEHPRTTLSEGHPGSDDPLARAHHPPAHVDSVTGVAHDDERLSTAHGTRQEQQHDTLAEGRSKRT
>NZ_CP011125.1|WP_157068588.1|358045_358684_-|hypothetical-protein
MLRTTSSLLVVALAVGCSGERLERPTCSGSVFHVAKADFAGEWTYRASLLREEDGELVVTDVATELAPVTVRIDEEHLLFVALDGAVLSGLWTDHVDVEHVVAESGEVCARVTAIERPWHERSALRPDVSQLILLDDPRAHPLGGALDVERAHTGALDGFELDQRWVRAEPERDAEGRAVRFAFLGHFRVRTCETGAPECTSTVRIGLELTR
>NZ_CP011125.1|WP_053230627.1|359220_360174_+|PrsW-family-intramembrane-metalloprotease
MTESYAIASAVACVIALALAVPVFAASSAKGQRVWLVALAVTQLPMAALTFFAVRVPIVRPLWSRLLEAFDPDAARALAAHDPDVLARSPLLAALLAIEAPLTEELAKLGPLLLALLWPPLRRRFFADDARRVPVALAIGLGFGLGEIWLLAVIGSGAPEVQGLPWYALSGFIVERVMVCGLHGLMTAVAVVQLGRGAARVTAGLLGAMALHVALNLPIVLSHARALGVASETWTMIATLWAQVFLFVMILVARWMHVRRDGKPRSFLGDVRCPTCKQVYARPLMGVNLPWARYEECGRCGTWQWVRASDEVADDLK
>NZ_CP011125.1|WP_053230628.1|360179_361211_-|NAD-dependent-epimerase/dehydratase-family-protein
MNELVLLTGATGFLGAHTTLALLRAGFAVRATVRDVEKAQARLGALVPPESRARLSFVGLDLGRDEGWADAANGCTYVVHTASPVPSGPVKNAAEVIGPAREGTLRAVRAAHAARVERVVVTSSIAAVIWGHARDGSKKYDEDDWTMLGPTVGAYEQSKTLAERAAWDYVASLPANERFELVTVLPGAILGPLLDADVSVSGQIVAALLGRAFPGVPDLGFALVDVRDVAAMHVAAMTVAEAAGQRFIVAGPHTSMRDIAAVLEREFVGRGFRVPTRALPSFLIKTMALWDPTAALTAGELGKRQDVSSERARRVLGFRPKSIEEMIVSMGETMITHRIVASK
>NZ_CP011125.1|WP_053230629.1|361282_362230_+|LysR-family-transcriptional-regulator
MTPDALRGLDVPLLVALSSLLETANVTASARALGRTQSSMSRTLARLRELFGDPLLVPVGRAMRPTPRAEELRPAVVQVLEGIGRLLAPPRPFSPREARRVVRIAASDYASVVLLNGWIDELRREAPGVVVQVSPVDASSIDPLARGELDLAIAPFLAGVALDQFVVRSLLRDEHVCVMRRDHPMAKKKLALRDYLALEHAMVASVLPTVSSVDEALHRLRVTRTIAARMPSVVSALMLVAQSDLVATSFARAVPPFGGMLVAKPLPFSVPPLELSVMWHPRETGDAFHRWLRESLLAHAATGRPRKRRSAPSRA
>NZ_CP011125.1|WP_075097423.1|362254_366520_+|protein-kinase
MPPSTSPPPPVLGRYRILRRLGAGGMAEVFLAKSSGAEGIEKVLVVKRVLPTFARSPKFVSMFVDEAKVAMRLNHPNIVQVYNFEQVRDEFLLAMEYVDGLDLGRLLAAARRKGRRLPYALCALVAMEVSKGLDYAHNRKDESGVAMDIVHRDVSPQNVLVSYDGAVKVADFGIARARMVSEETGVIKGKFSYMSPEQARGQRVDRRSDVYSVGVLFSELLMNRAMYPGLQGMEVLEQVRDGRISAPRNVDSNVPAELDAIARRAMSFDREERYQTGRSLAGALSRWLHEQDDLHDGGELERFLLEVAPREVTSPEGPRRASESPPAGTHATHMQMQQGREIRERRNVVVVAGRLRDAREREAVTGVEKTGEAASDLAARVLDDIAFKYDAILEWPDGAARRSFRFALGLGRVSVDDPLHATRLALDVLEALEGISADALVPFTASIGLSRGLVTTVRTGPRLRHEPIGNVFDVARGLADAGAREEILATGEVYRLARRAFAFDAQDVRDVTVTTHGGGATMRHIRAYKLRGARTREERAAEARTLATQVGLFGRANEIQALVETWVEVCASKRSSRLAIVGELGAGKSALVAAALGRFQPDPRLLRVECAFGANEVPYAAVAELVREACGIPEDATPDHTLELMRESVSRLIKVSDKRKSVIDALAPLLVPSFSKDGDAESGDPSQLVAMAVRDLLGALARQGPTVLWVDAVQFADAASLQLVARLLAQTYDNALLVILCTRPGDRVEPLLRGIPRLDLGELADEDRKALIVAQLGGAHVPADLHQAIVHRAGGNPFFLLELVEALLDRGVIRVEGEGDGKRVVRRQGAHLALPTSLEDVIAARITELPDRERIALRWLSVVGPGLREGEVSRVAGIPIDDAIASLEARGLVLRKAGGALAFSSAVVRHVAYESIEPGDRARMHRRVGAWLAGLDVPVAPSRVARHHELAGDHAAAAAAWKEAGRAALAVYSNRDALRFFARALQLLPDDAPDRFELHEVREQILRVLGLRAEQRIELEAMRAIAEGAGAQRTREPRLLAIAMCRLARHDLDASRPVGVEAMLRRALDAAIEAGDKSAEVEAMRLFGHLRRDTGDVHGALEAFDRALARAGLDPDQLGARGLTLVQKGILLWRVGNLQSSLDASAESVAIFRRLGHKGHEAYALNALGVCLYSSGAFEDAIAVIRASILLDREVGDRLHLGRKAGNIGQMYADLGDVTRAMEFLRRALDVFESLDDQSGRVDTLTTMAELLVEQVGDLDAAQSALDDARGIAERLGDPYDLAHERIVRASLFAARGDHPSAEQAARAAVAHARTAAAAGYELLAAALRARFLAKLGRAQEARDLAREVQGGVRTRGVVERAQRLYFEVASALADAGDPEGSARALADARAVVDAHLAQIRDGALRDRYLATPVVRAIVSA
>NZ_CP011125.1|WP_157068589.1|366629_366914_+|hypothetical-protein
MSRILVVVLAFAMLAFAPSLAAGQSAEPAGYPRVIPRPAPEAEPEPEPDEAPPPRRARADRRASSATTVVRRPTRGAHTARRAHTTPSGERRPR
>NZ_CP011125.1|WP_157068590.1|366987_367503_-|cupin-domain-containing-protein
MASKKVVIKKGEGDAYWFGGVLMEIKVTGRDTGGQMAVVEMTAPANLGAAAPLHTHAGDETLYVLEGTIRVHVGDEVTELLAGSQMHIPRDTWEYYENVSNKTARVLVTYSGAASNIDQFFREAGQRATSRDVSAIPKGAADIATITQIGKKYGIEVKAAPARPQAAAPPR
>NZ_CP011125.1|WP_053230633.1|367729_370081_+|response-regulator
MQRIREGEDVADDADARAEQRYRELASYLPDYVSVVDRERRFRWINRAQPGLSREALMAGGRVDDFVEPDARARTVEAIERVFATGAPDEVELVATGDGVEPRWYRVRVVTAPPEAGEPRVMLLATDITAQKHAELEVRASERRVHEILERLPDYVLELDRDHRIRFVNRTRHDTTEDVVIGQRIDDLAQPDMREEVTEKLERLFTTGEDVRWTSHSTVDGGAYVVHAVRVPGEPPRALLVAKDTSREQQALSALHTSESRLERALRAGNVAVWELDVESGEVQHVGWIGRVLGDANERLTRARWLGLVHPDDVERVRTGVDALIARRTESYEQEYRVQDSRSGAWLHVLGCARLEARPDGGTAVVGTVIDVTAIRLAELERRELERKLEQVQRLESIGLLAGGIAHDFNNLLTVISAGAECARRRFANGQSPDDELHEIVEASQRAASLTQQLLAFGRRSALQLEDVDVAALVSGIASMMQRVLPRSIEVVLGGIEGDAVVRGDLHRLEQVLLNLCVNARDAMPSGGRLTLSTSVVGHEVLVEVVDTGVGIAESERARIFEPFYTTKPVGTATGLGLAVAHGIVRQHGGAIDVSSAVGDGTRMTVRLPRQLGARAAAPAAQPAPRGGHETILVADDEPLVLRMAKRTLEGAGYRVIEASDGAQAVDVFRARAHEIDLVVLDVIMPQLDGWRAHQQIRAIAPQMPVILTSGYSASAIPEHVLEQDDAGERTSAVRVKAPPMLAKPYGPDGLLRTVREALDRDRDGTTRARKERAGQPGGRQGT
>NZ_CP011125.1|WP_053230634.1|370077_371238_+|hypothetical-protein
MTDSPVRRLVAQTLKPFHRKPGMIDTSELSMALFADARDAGVEAITGSGVGLELHAGERVLASALLVDRPKGYEHRLAMAITDRRTAVSGWSSISGPGSFNNRRFSVAHAELTRVEVKTGMLTNHVALFAGNTKHELIFGELVQPLGALYQALTTQIAPGERVEPPTAWPASSDADPAGAHAAAQALWNDDPLARQALETIDRNVRHAGMPAEMGRDLVARVVLAHRTSATAPAMREGRWLSPMSAQDLGGTLVRFFGAPMTHAQPQPGVEQLDFRIDPKRDVLYDAVTALGVASYIGLGVGFRPGAAIADALLRKQQVTQLRVMFADQAGGAAYRLFAPPQPLEPCDSRLAQRLHLALGAASYSVLLRRAERGWGPSYAELFPKT

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Crispr_ID: NZ_CP011125_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_2

588418-588518

Orphan

Consensus_repeat	Method
CCGCGACGGGCTCGCTGGGGGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_2

>merge|NZ_CP011125|2|588418-588518|CRISPRCasFinder
CCGCGACGGGCTCGCTGGGGGCCTGCTCGGGCGTCGGCTCGGGGGTAGGCGCGTCGACGGCCGCCGGCGGCTCGGGAGCCGCCACGGGCTCGCTGGGGGCC

>NZ_CP011125|2|2|588418-588518|CRISPRCasFinder
CCGCGACGGGCTCGCTGGGGGCC	TGCTCGGGCGTCGGCTCGGGGGTAGGCGCGTCGACGGCCGCCGGCGGCTCGGGAG
CCGCCACGGGCTCGCTGGGGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053230791.1\|597799_598879_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187539
NZ_CP011125.1\|WP_053230790.1\|595861_597772_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226708
NZ_CP011125.1\|WP_053230793.1\|599888_600464_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239632
NZ_CP011125.1\|WP_053230782.1\|586103_586661_+\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|223917
NZ_CP011125.1\|WP_053230787.1\|593568_593940_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230779.1\|583569_584046_-\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|376792
NZ_CP011125.1\|WP_075097428.1\|600931_601501_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NZ_CP011125.1\|WP_157068627.1\|587330_587675_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230794.1\|601479_603249_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053230777.1\|581673_582909_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236792
NZ_CP011125.1\|WP_053230780.1\|584236_584890_-\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|376576
NZ_CP011125.1\|WP_169791304.1\|580657_581740_-\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481
NZ_CP011125.1\|WP_053230788.1\|593986_594880_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_083457097.1\|592531_593572_+\|recombinase-RecA	unknown	unknown	gnl\|CDD\|236476
NZ_CP011125.1\|WP_053230778.1\|583005_583545_-\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|376792
NZ_CP011125.1\|WP_083457095.1\|585445_586069_+\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|376576
NZ_CP011125.1\|WP_053230786.1\|590932_592474_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl\|CDD\|223679
NZ_CP011125.1\|WP_053230776.1\|579044_580637_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_CP011125.1\|WP_083457096.1\|586666_587269_+\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|376792
NZ_CP011125.1\|WP_053230789.1\|594882_595761_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|237621

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053230791.1\|597799_598879_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187539	cd05228, AR_FR_like_1_SDR_e, uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs. This subgroup contains proteins of unknown function related to aldehyde reductase and flavonoid reductase of the extended SDR-type. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. The related flavonoid reductases act in the NADP-dependent reduction of flavonoids, ketone-containing plant secondary metabolites. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.12365e-40
NZ_CP011125.1\|WP_053230790.1\|595861_597772_-\|hypothetical-protein	gnl\|CDD\|226708	COG4257, Vgb, Streptogramin lyase [Defense mechanisms].	0.000749463
NZ_CP011125.1\|WP_075097428.1\|600931_601501_+\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	3.30711e-59
NZ_CP011125.1\|WP_053230794.1\|601479_603249_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.41157e-96
NZ_CP011125.1\|WP_053230789.1\|594882_595761_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|237621	PRK14139, PRK14139, heat shock protein GrpE; Provisional.	0.00531212
NZ_CP011125.1\|WP_053230779.1\|583569_584046_-\|biopolymer-transporter-ExbD	gnl\|CDD\|376792	pfam02472, ExbD, Biopolymer transport protein ExbD/TolR. This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.	9.10094e-13
NZ_CP011125.1\|WP_053230782.1\|586103_586661_+\|biopolymer-transporter-ExbD	gnl\|CDD\|223917	COG0848, ExbD, Biopolymer transport protein [Intracellular trafficking and secretion].	5.15371e-08
NZ_CP011125.1\|WP_053230777.1\|581673_582909_-\|hypothetical-protein	gnl\|CDD\|236792	PRK10905, PRK10905, cell division protein DamX; Validated.	0.000944322
NZ_CP011125.1\|WP_083457097.1\|592531_593572_+\|recombinase-RecA	gnl\|CDD\|236476	PRK09354, recA, recombinase A; Provisional.	0
NZ_CP011125.1\|WP_169791304.1\|580657_581740_-\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	2.28679e-166
NZ_CP011125.1\|WP_053230793.1\|599888_600464_+\|hypothetical-protein	gnl\|CDD\|239632	cd03577, NTR_TIMP_like, NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. This group contains domains similar to the TIMP NTR domain, which binds MMPs. Members of this group may or may not function as MMP inhibitors.	2.28123e-10
NZ_CP011125.1\|WP_053230780.1\|584236_584890_-\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|376576	pfam01618, MotA_ExbB, MotA/TolQ/ExbB proton channel family. This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels. MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller. ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.	7.216e-26
NZ_CP011125.1\|WP_053230778.1\|583005_583545_-\|biopolymer-transporter-ExbD	gnl\|CDD\|376792	pfam02472, ExbD, Biopolymer transport protein ExbD/TolR. This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.	1.54496e-08
NZ_CP011125.1\|WP_083457095.1\|585445_586069_+\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|376576	pfam01618, MotA_ExbB, MotA/TolQ/ExbB proton channel family. This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels. MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller. ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.	1.02893e-21
NZ_CP011125.1\|WP_053230786.1\|590932_592474_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	4.92992e-176
NZ_CP011125.1\|WP_053230776.1\|579044_580637_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.78359e-64
NZ_CP011125.1\|WP_083457096.1\|586666_587269_+\|biopolymer-transporter-ExbD	gnl\|CDD\|376792	pfam02472, ExbD, Biopolymer transport protein ExbD/TolR. This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.	5.55462e-10

>NZ_CP011125.1|WP_157068627.1|587330_587675_-|hypothetical-protein
MSAALVRTLHDESAPVIAHAVCACADELGVASLPSAVRTSAILVPARGAIVDVRPLADAAGVIVDTEGTLDACIARRAASARLPAHVIGSDVQPDPDPTDERVVMSVFVHVDAR
>NZ_CP011125.1|WP_083457096.1|586666_587269_+|biopolymer-transporter-ExbD
MASESNTPSGGHGEKATMAQVKGLVRRKLRKVPPHEEQSLNIYPMMDIMTIILVFMIMQVANETANISQSDELQLPWTTSTEQLTEALAIQISRTEVIVDGRPVVQLRNGTVDPSQKQGGANGFLITPLLNEMQQHRDRLKLIAQRNPRRPFTGEVQIIADRRTPFRTLSEIIYTIGQAEFAHMHFVALEESQGGGGGGH
>NZ_CP011125.1|WP_053230782.1|586103_586661_+|biopolymer-transporter-ExbD
MELTPRQQAYVRKRTKHDEPDPSEVAGELNIVPFLDIVVNLILFLLATSAQVMIVAELDAHLPSLSRGRRASSSTEQGSTLNLSVTIAENGIIVSGSGGKLAPGCTQMQSGRVITVPRGGDGTYNWRALTECVARVHSQFPDENQVILSADPSIEYEHIIQAMDAVRAQGTDPLFPNVMLSAGVR
>NZ_CP011125.1|WP_083457095.1|585445_586069_+|MotA/TolQ/ExbB-proton-channel-family-protein
MEAIWHALRDGAPFSFINVAVLAIVLAIIAERFVYILTKYRVNSREFMAQIRKLVQAGNIDRAIKLCEAAPLPLLQVVKAGLTQVNRGDEAVIASMEERWAELHPELEKRIGALWTLANIATLVGLLGTISGLIRAFGALGSAAPAQRAALLAAGISEAMWNTALGLGIAVICMTFHLFLHSQAKKIKQDMELSTMKLENLLMQKGR
>NZ_CP011125.1|WP_053230780.1|584236_584890_-|MotA/TolQ/ExbB-proton-channel-family-protein
MATLAHHFEEGGWGMYPILFWQIIAIGIIIERSIYLYRSSINRDVFLATMQKCILAGDIGRAIKLCSAANAPLARIVKAGLMKVNRPDSEVQAAMDEAALRELPKIEQRTGYLALLANLAMLSGLLGTVTGLIAAFGAVANADAASRATMLARGISEAMNCTAFGLLAAIIALIGFAVLNGKTQSLLDDINGATVQVMNLVVNNRSKINLQGLQQAA
>NZ_CP011125.1|WP_053230779.1|583569_584046_-|biopolymer-transporter-ExbD
MGGISVGGGHGGKKSVDSEIPLVPFIDLLLCCVMFLLVTAVWNRLARLDANQQVPGQAAQPDQPPPEETIRLYLQVTQAGFTIASTAGERIEIPKASGEYDLETLRTRLTERRTAEPNRRDLIVAPEDGVLYEDVIAAMDLAVGQGFEDVSLSDGAAL
>NZ_CP011125.1|WP_053230778.1|583005_583545_-|biopolymer-transporter-ExbD
MPIHKPDRVLLHHVPLKFVRSKVAGGGRKSMDSQIPLVPFIDFLITLVVFLLSSFSASGELLSQRPNLVMPNATNAIDLELAPIVAIDARVVTLDGRRMADTPTLAANAGLERIEQLVSDLETLRRNWSILHAREPFPGTVIVQADRSIDFRVIKKVMFSAAQAGYTNISFAVNQTGGD
>NZ_CP011125.1|WP_053230777.1|581673_582909_-|hypothetical-protein
MSDEKDPNEPALKPARPEPDELLGRPSYMPRIPWKWIVIFGGMAALAVGAYQVRERQRADAMRTQVLDTYDEHLSSLSERYVGFRQQLEQWTMEAAQAGEPERWVDPRLRISGLHSGDGVYLRLTAEQASSREGIAQAAMAMEQDALTRCLGIAPASARGLYETGSFLSPEWRDEARATSDYMRLRVMDEQLARNIEVDVPVVASLLGAQYFLLVVQQGDNRRDEPVDVFLWDLREQRQLLRARVHARGILLPVRLRFDGVAPAPPTDGHPQMRSGGAHDCSIAAQIKALTGEAPLTVESGDVLQRRMEEQQAERTAPEGTAPTEGTAPRKAPRPRQKAPRPRQKALRPPKTRLPSPQREARPRPEPSSTTCASTSPPSRAASCAPPTSRWISRSSSRTTARSRPTSAPRA
>NZ_CP011125.1|WP_169791304.1|580657_581740_-|alanine-racemase
MDLAQLVANYRAIQAHVGASRVMPILKANAYGHGLVEVARTLESIGAPMIGVAYLEEGIRLREEGVRMPVLVLGGIVGEQIPLFLEHDLTLCASSIDKLRAIESCAESKKVRAKVHLKIDTGMERIGVHWYSAEGLLEASLACRHVDVEGVFTHFANADEGDLAHARLQLERFHEVLRFYERRSIAPPLRHAASSGAILALPESHFDMVRPGILFYGARPSPHVPDLVPVRGALRWVTRVVYFKVVKPGHSVSYGSTWTPSEMTRVVTLPVGYGDGYPRALSNRAEVILRGARHPVVGRVCMDQLMVSVGWGSAYNGDEVVLLGRDGDHEITVEDLAAWAGTIPHEILVGINTRVPRVYR
>NZ_CP011125.1|WP_053230776.1|579044_580637_-|FAD-binding-oxidoreductase
MRRRSHWAWGWADRFPDRDARRAIGEQVRAITSFDVKDVTEPVALDAITMPAPRIDAPPSLAAITSIDHEDRALHTRGRSYRDVVRGFYGDFASAPDLVMRPRDEREVDAILDWASSARVAVVPFGGGTSVVGGVEMDERRETYAGVVSLDLGAMTRVLEVDATSRAARIQAGATGPQLEAQLAQHGMSMRCYPQSFEHSTLGGWIATRAGGHFATVYTHVDDLVESMRVVTPRGLIETRRLPASGAGPSPDRLMLGSEGIFGVITDAWVRVQVRPTFRASASVKFTSYERAVDATRAIAQSGLFPSNCRLLDQREAMMNGVAMGASVLVLGFESADHPLEAWMERALSIAREHGGESEGATYRSGAGSADDAAGRWRQAFLDAPYLQSSLVSLGMIADTFETACTWDRFATLHAAVVRAVRDASARVCGAKALVSCRFTHVYPDGPAPYYTFVAPATRGRELEQWTEIKRAASDALMAHGATITHHHAVGRLHRPWYEQERPSLFEHVLRATKRELDPAGILNPGVLLA
>NZ_CP011125.1|WP_053230786.1|590932_592474_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MLSRVHAGCLVGIEARPVEVEVHLGKGLPGFDLVGLPEAAVRESRVRVRAALATSGFELPPRHVVLNLAPADLRKRGASFDLAIAIAVLSASGLCAPNLLDETLMVGELSLAGELRMVRGVLPLLQLARARGLSRAIIPAGHAAEARLVRGLEVRAARSLGDVVAFLGATGDLPRVDASPAPRAVRDPDEPDLAEVRGQDGARRALEIAAAGHHDVLLIGPPGAGKTMLARRLPGLLPPPDDDERAEIATIASAAGLDGFDGGARRPFRAPHHTASAAALIGGGDPVRPGEVTLGHAGVLFLDELPEFARPAIESLRTTMESGVAVVARARERVSMPARPLVVAAMNPCPCGFSGEPTRLCSCTPSRVEQYRARVSGPLLDRFDLHVALPPVKLAELGDAAPSESSAAVRARVIAARERAIASGDVIGVKTANPSRSLERDLASLSPDARTLLDLAGERLGLSMRGFSRALRVARTIAHLAAAGRVEAPHVAEALQYRLLDRRVSGAPAVRAG
>NZ_CP011125.1|WP_083457097.1|592531_593572_+|recombinase-RecA
MTSMKEKLKAVQQAVSAIEKQFGKGAIMALGEPRNIEPVAVIPTGAPSLDAALGCGGYPRGRVIEVYGPEASGKTTLTLHAIAECQRAGGIAAFVDAEHALDLRYAAALGVQTENLLVSQPDNGEQALEIAETLVRSGAVDLVVVDSVAALVPKAEIEGEMGDQHVGLQARLMSQALRKLTGITHRTGATIMFINQLRMKIGVTFGSPETTTGGNALKYYASVRLDVRRIGQVKVGEEITGHRTKVKVVKNKLAPPFQLAEFDIRYGVGIDATADLLDLAVTHGLVEKNGAYFSFGGQSLGQGREKARIALCEDAALRATIANAVHAALAGAPKSAGSPELEEAVA
>NZ_CP011125.1|WP_053230787.1|593568_593940_+|hypothetical-protein
MTARVRALPKRDVAGEALVHVERATHALHVELKDELARVAERQPELSVWLTTALWMLEMAAKDLRTEPDRERRRAGVAVAQMHAMRVSTGLELASAMGVLDADPEAFDLRFASILAELERARS
>NZ_CP011125.1|WP_053230788.1|593986_594880_-|hypothetical-protein
MMRLLRFVTIVLAMASVGPGCTAITSGDFEERAEPLVCGNDLGSSRVDMRLDLTDMNAHLDNLTVANLVRIEGSGAARVRRTVARAVLDPLGEANLQIPLPCTVLDGNHEVDLVADLNGNRMYDPCPRAPEGCEDHQWRLMLQADGTVSYQHDVDFVDLAQGAPLPRGALPVRAAFGNMSQFAGRRMEVHVRRPLEEGGFETVLVYVLGAIPDTNDMLVRREENLIELRERYEVAIWIDTNGNGTYDPPSSIGAEGRDYATTIDAVGEPPGAVDPGGVQVLFDGQSPPPQEDIALEP
>NZ_CP011125.1|WP_053230789.1|594882_595761_-|tetratricopeptide-repeat-protein
MDRRRRGTLLASALIAAACALAPTTRASAQPPQGGGGGSESMSQATTTEGDMNDERARGAFRLGRQYYEQGRFADAASEFERAYGLSGRGQLLFNAYLAYRDARDDENAIRTLRGYLAQVEEIPDRALLEARLAALERGLAERREAEARAQAETDEARRQAEEARRQAEEAGRPRYREIPGETWPWIVMSGGGALIVAGIVTGAVALGERSALDEDCPLQLCPAGSDVEGRQSTIEALAITTDVLLVTGAAAAVTGLVLGLVLGPRTEAIETPPVSAACTGEGCFVAVRGDF
>NZ_CP011125.1|WP_053230790.1|595861_597772_-|hypothetical-protein
MRRFARVLALLLALGCDGSPPCVDEDLDGLGTHCEAGPDCDDGNAARGEDCDAVPAPDCTVDPTATGCPCLIGSVTDCFPGPSELAGVGECRTGRTRCVAQHWGLCDGSQGPSRERCDTLDQDCDGLADEGVRSPCGGCTASCTGELWGEPFDEAGGGLVVTGLGELTLAREERSSATVWAVNSAEATVSRIDAIEARETARYATGERDAVALEPSRVSVDWNGDAWVANRAFDGVPSVVRVAGDRARCVDRDASGTIETSASPEDVRAWGSDECVLASTIIGGAREVARAIAIDGDRGLDGVSGGDAWIGLHDGQAFVEVDGLRGDVIQRVETPGFSPYSAAFDPWGRLWAISRDGWLARIDPSADPPSLEIVEVPLACWLLYGMAIDGEGRIAMTGFSCDSVTIHDPRTSRWSTIRTEPSPRGAGFDGADLWVAHTGGRVSRLSLDPLRVVATRSLALDDVAPVDSIGIGADGLGHVWAISGAGGGAGLGVATRVDVEDAIAGAQVPVGASPHTQGDLAGLQLFGAPVPRASAQRVFDGCGADVTTSWVNVHVAGDPGTHGTIAIEVRHASDVASLASAPWISLGTIPDDAAPFPLALPEGGVIEVRVTLAVSASLGAPRLTRVGVEWTCPGPE
>NZ_CP011125.1|WP_053230791.1|597799_598879_+|NAD-dependent-epimerase/dehydratase-family-protein
MSAPTSACYDGAVKVVLTGATGFIGGAIARRLLDRGDELTVLARDPSAAASLAQRGANVATGSLLDPNAIARAARGADVLVHAAGIPSPRASARALRWTLVAGTENVLSAARHAGLERVVTISSADVTLANVDRVHWDEKRDLAQLPIGERARALRLAEEIALSTSDAELAVTALRPGWVWGPGDLSTLPELVREARSGGIRMFGDGRNLVATTYVDTLADAVIAAARAPGAPGQAYYVGDPEFLELREFLQQLSRTLTLPAPRPGPPFALVYPLAVLRAGRGGATLPEEILRRARSTLFDVQKAIAELDFRATISVDEGMKRLSSWVNEVGGLDAVLAKARPLPDEATLEREASAAGA
>NZ_CP011125.1|WP_053230793.1|599888_600464_+|hypothetical-protein
MIRLSIAALIASACALLGVPRAHACSCVETPFEQLAAEADAIFEGRVASIEPAGEMHVRVRLDVVQTWREANAEHVEVRTASQSAACGVHFEVGRSYLVLAERADGEWTASLCGGTRAMEDADDERLSLGSGVIPVDIEDEETASTEQHPQTLPPRGGGCAGCAITSPAGSPIAPAIALVIAMWMRRRRIR
>NZ_CP011125.1|WP_075097428.1|600931_601501_+|nucleoside-deaminase
MTDSGDALPCSDVDASFMREAIAEARLAEAKGEVPVGCVIVLEGAIVGRGHNLRETMQDPTAHAEMIALRQAASTIGSWRLEHAIAYVTLEPCPMCAGALVNARVARVVYGADDPKAGATTTLYTIGSDPRLNHRFVLVPQVLGGECGALLTDFFGRIRAARRAARAGITPDVPPPPAKPRRDQEPEGG
>NZ_CP011125.1|WP_053230794.1|601479_603249_-|serine/threonine-protein-kinase
MNAPGAPEWLGPYRLVERLGQGGMAVVYRAERTGDAGFKKKVAIKRMLPQYRRDPSLLERFAAEARTNARLDHPNLVQVLDFGIDPEPYLVLEFVEGVTLGAVMQRLAERNEMLDIAAVAYIGAEAASGLDHAHRKKGDDGTPLGIVHRDVSPQNVLLSNEGTVKVSDFGLVKAADNVLKTQSGVTIGKMSYMAPEQAQGIDVDARADVFALGVTIWEMLTIRSLIPPDDPQVAANLLRSGDFPPPSRFNPEVPPRLEKIVMQCLAIDPAARTPSAQQLAQDLRELLHERAAGYGRQQLARFLQWLFPEQGWELPEPERPPAQPSADERASFVPPTPVALAVARAEADAAAMPIEVAPPISPAAPAPSGSLPIVGGSSASHARVKAPLSALALSAMVGASAVIVLLAIAGVAWLVVRHASQSMPPEPASTAPPLQPLGAGVTIESPTAGVRLFLGPRELGAPPLRLTPEQLTGEPLVALAPRHQPLVIRAERLVELTRTVGRVHTVDLEPSQRPDWMVYVRYDGQGTAHLPEGDELGPVPGVVRVRTRRDLPTPDAIVIFDESGDHATSVSLEGCEADKVCVLYPPSGS

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Crispr_ID: NZ_CP011125_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_3

610361-610576

Orphan

Consensus_repeat	Method
GTTCAGGGACGTCTGAGGCTCAACCACGGTCGGGTTCTTGACCTCGTTCA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP011125_3

>merge|NZ_CP011125|3|610361-610576|PILER-CR
GGCTCAACCACGGTCGGGTTGGTGTGCCCATTTGCGGGCACTCGGGCTCAACCACGGTTGGGTTTCGAGTGCCTCGTTCAGGGACGTCTGAGGCTCAACCACGGTCGGGTTCTTGACCTCGTTCACGGACGTCTGAGGCTGAACCACGGTCGGGTTCGAGTGCCTCGTTGAGGGACGTCTGAGGCTCAACCACGGTCGGGTTCTTGACCTCGTTCA

>NZ_CP011125|3|1|610361-610576|PILER-CR
GGCTCAACCACGGTCGGGTTGGTGTGCCCATTTGCGGGCACTCGGGCTCAACC	ACGGTTGGGTTTCGAGTGCCTCGTTCAGGGACGTCTGAGGCTCAACCACGGTCGG
GTTCTTGACCTCGTTCACGGACGTCTGAGGCTGAACCACGGTCGGGTTCGAGT	GCCTCGTTGAGGGACGTCTGAGGCTCAACCACGGTCGG
GTTCTTGACCTCGTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053230793.1\|599888_600464_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239632
NZ_CP011125.1\|WP_075097428.1\|600931_601501_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NZ_CP011125.1\|WP_053230355.1\|604271_605705_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|372641
NZ_CP011125.1\|WP_075097411.1\|608938_610255_+\|transposase	unknown	unknown	gnl\|CDD\|379252
NZ_CP011125.1\|WP_053230790.1\|595861_597772_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226708
NZ_CP011125.1\|WP_053230797.1\|614814_617313_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP011125.1\|WP_075097429.1\|610678_611872_-\|TIGR04552-family-protein	unknown	unknown	gnl\|CDD\|275345
NZ_CP011125.1\|WP_053230794.1\|601479_603249_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053230356.1\|606075_608850_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_169791306.1\|620660_621920_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230354.1\|603342_604254_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230798.1\|617413_618223_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237907
NZ_CP011125.1\|WP_169791305.1\|618226_620596_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227511
NZ_CP011125.1\|WP_053230791.1\|597799_598879_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187539
NZ_CP011125.1\|WP_053230796.1\|612399_614802_+\|endopeptidase-La	unknown	unknown	gnl\|CDD\|223542
NZ_CP011125.1\|WP_053230803.1\|625255_626011_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224722
NZ_CP011125.1\|WP_157068629.1\|623230_625144_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238742
NZ_CP011125.1\|WP_157068628.1\|611903_612128_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230801.1\|621909_623226_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230789.1\|594882_595761_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|237621

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053230793.1\|599888_600464_+\|hypothetical-protein	gnl\|CDD\|239632	cd03577, NTR_TIMP_like, NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. This group contains domains similar to the TIMP NTR domain, which binds MMPs. Members of this group may or may not function as MMP inhibitors.	2.28123e-10
NZ_CP011125.1\|WP_075097428.1\|600931_601501_+\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	3.30711e-59
NZ_CP011125.1\|WP_053230355.1\|604271_605705_-\|ATP-binding-protein	gnl\|CDD\|372641	pfam13589, HATPase_c_3, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	1.70095e-05
NZ_CP011125.1\|WP_075097411.1\|608938_610255_+\|transposase	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	7.24997e-12
NZ_CP011125.1\|WP_053230790.1\|595861_597772_-\|hypothetical-protein	gnl\|CDD\|226708	COG4257, Vgb, Streptogramin lyase [Defense mechanisms].	0.000749463
NZ_CP011125.1\|WP_053230797.1\|614814_617313_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.76033e-06
NZ_CP011125.1\|WP_075097429.1\|610678_611872_-\|TIGR04552-family-protein	gnl\|CDD\|275345	TIGR04552, hypothetical_protein_Q664_03455, TIGR04552 family protein. Members of this family are bacterial proteins, roughly 400 amino acids in length. Most members belong to the Deltaproteobacteria. All members of the Myxococcales, and order withing the Deltaproteobacteria, have a member. The arrangement of conserved residues into invariant motifs suggests enzymatic activity. The function is unknown.	3.42621e-124
NZ_CP011125.1\|WP_053230794.1\|601479_603249_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.41157e-96
NZ_CP011125.1\|WP_053230356.1\|606075_608850_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.50546e-88
NZ_CP011125.1\|WP_053230798.1\|617413_618223_+\|hypothetical-protein	gnl\|CDD\|237907	PRK15092, PRK15092, DNA-binding transcriptional repressor LrhA; Provisional.	0.00665016
NZ_CP011125.1\|WP_169791305.1\|618226_620596_-\|hypothetical-protein	gnl\|CDD\|227511	COG5184, ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton].	3.79326e-23
NZ_CP011125.1\|WP_053230791.1\|597799_598879_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187539	cd05228, AR_FR_like_1_SDR_e, uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs. This subgroup contains proteins of unknown function related to aldehyde reductase and flavonoid reductase of the extended SDR-type. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. The related flavonoid reductases act in the NADP-dependent reduction of flavonoids, ketone-containing plant secondary metabolites. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.12365e-40
NZ_CP011125.1\|WP_053230796.1\|612399_614802_+\|endopeptidase-La	gnl\|CDD\|223542	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP011125.1\|WP_053230803.1\|625255_626011_-\|hypothetical-protein	gnl\|CDD\|224722	COG1809, COG1809, (2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM biosynthesis) [Coenzyme transport and metabolism].	0.00296846
NZ_CP011125.1\|WP_157068629.1\|623230_625144_-\|VWA-domain-containing-protein	gnl\|CDD\|238742	cd01465, vWA_subgroup, VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known.	1.24459e-23
NZ_CP011125.1\|WP_053230789.1\|594882_595761_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|237621	PRK14139, PRK14139, heat shock protein GrpE; Provisional.	0.00531212

>NZ_CP011125.1|WP_075097411.1|608938_610255_+|transposase
MAESRLRTLAEVLEVVRPAFTRPTFERFVALMRGWLLTQQAGAVTSALLGAGLAGRAHHAAFHRLFAEAAWDVDEVGTELLKWIVRTCATRRSLQLAIDDTVVRKKGPMVFGLGTYLDPVRSSRRVRNFVFGHLWVVLVAIVEVPFSKRRWAVPIFFRLYRQERDCTRTNDPYAKRTSLARELIDLAARVAPELTMHVSADAAYCCETVLRGLPKNVVVYGTLRDNAVLTAAPIARRGCTGRPRVRGERMPTPAQLAADPSRWRSTRAALYGRTRALAFKQMDAQWYQGRGPELMRVVVVRLSAGKLKHRVYFCTDPTRTPADIVERYTARWQIEVCFRDLKQHLGFGASPAWSRRAVERVTPFAGFVYSIVVMWARLSLRRPERAPQIRRPWYRDKVGLSFADLLHIARTDLLDPAARTQLARNSPVSDRSRSFAAA
>NZ_CP011125.1|WP_053230356.1|606075_608850_+|serine/threonine-protein-kinase
MIPFGKYLLLDRIAVGGMAEVYTAKSFGIEGFEKIIAIKRILPTMAEDEDFIQMFIDEAKIAGHLTHANIVPIYELGKIGESHYIAMEYVWGKDLLQIMNRFRRMRRHMPPVMAAWIASKMCEGLDFAHRKRDRHGRPLNIIHRDVSPQNCLVSYEGQVKMIDFGIAKAAARNTKTQAGVLKGKFGYMSPEQVKGSGVDHRSDVFAVGTCLHEMLTGERLFVGESDFSTLEKVRNADVIPPSQTVPDMPAELEQILLKALAREPEERWQSAGEMHEALQMFVAREKPPFGTSKLAAWMRTAFAPEMTKEKGRLDGFAKIAKPASVPPPPPNRASAPGAAKDAMASTSPDNPAVRRPPAPPPPARPLPPPVAVGAPVVPPPMNDVDEDDDPGELQSESTMISSSPFDEMTDGGGEELQGAPTQIFFSADELEEAPKPAPQMGAPAGVVVSPSVHVHQPAGMPMPAPAMPAPMQRAPSLPPEERPTTAPLMDYGAPPMAQGGQPATVVHASPYGAPPPMAMGAPPMPMGQPMPTGHPMPMGQPMPMGQPMPMAQAQPMPMPQTGPTPGFAAPPAFGAPPPAFAQPGAEALDPGMRPRSAAQETLELRSPVIAPKRSRVALFVGLGAFVFVALAASLAAFLVFGTGPAGGTIEIRTNPADAGATVLVDGTPRGRAPLRLDHVPSGDHLIEVRADGFQPATQTVPVSDGTTAMLLIPLMPGGAPAIAAVAPPPVAPAVVPPPVAAPTPPPVAPTPPPTEVAVAPTPPPPAAPTPPPPAVVAPPPTPVATAPTTTPREAATTTTPRQATTSSSSGRTETASSSARPVATASSITPRSRSGEETSRSSSSSSSSSERRSSSRERGYLMIQTLPWARVFIDGRDTGQNTPVRRMEVPAGSHRIGLRTNDGRMHEVTVEVPAGETVRIVRQL
>NZ_CP011125.1|WP_053230355.1|604271_605705_-|ATP-binding-protein
MARSAWFEIAEEGWARLSAARPLGRLLLEAVQNAFDADAANVAIEIEPDRVVIEDDARAGIADERLVYTLFLSDKPRDPTRRGRMGRGLKELLAAAERAHVETIGTTIVFDGEGRRTETNTRESGTRLELFRAIGDDEREAALDLLRLAIPPRGTSLRVAGRLVRRPRSVLALADCELETVVIDDGVERAAMRPTRVAIYAPRRGERPSLFEMGVPVQPWNVPWHVDVAQRVPLGEGRDAAPERFVLALKATLLEAMVHSYLDRRDLRADWVQDVIARWPVKSGLLDAYVSKVFPRGSVLGGTSRANDRAKQLGAHIVDARTISHGAWLALARVLETSDDYVRRRSSEFGGDEVEPDETQRRFAEAVRWLARRVAGSVVRVRFFARDPSDAGLLEDAVTDVDARAISFNVKGPLRFDDVLDPGTIGVVLHELAHLASVEHDHRFIDRLQLLAGMLAKLLADGGPALATALRRGDPER
>NZ_CP011125.1|WP_053230354.1|603342_604254_+|hypothetical-protein
MTRSRPTLDISLPTEPFAAQHTPRRDVRTLCRWLEGALPGGSAGIATLLERLHGPLAERRHLVAVALVVAHLRGELRGARWLRLTGTENADPRDIDREMDLVWDALARAKLVRGALRYHPGTTQHGMARFPPRLVPRWVRTNRWSLLGQDDDLLLFEPDYMEPLLRGAAEPGAARRDLARGIVAHAARDAAHAVVAAPRYAGGETLATFAPRYARWAKIARETDALEVAAYLERLASYGAPRTFDAEQALQAFRDLSRCWPAEPKVVRMREVKDGFTGSVPGTSRRPSRVHIDRETGAITRVR
>NZ_CP011125.1|WP_053230794.1|601479_603249_-|serine/threonine-protein-kinase
MNAPGAPEWLGPYRLVERLGQGGMAVVYRAERTGDAGFKKKVAIKRMLPQYRRDPSLLERFAAEARTNARLDHPNLVQVLDFGIDPEPYLVLEFVEGVTLGAVMQRLAERNEMLDIAAVAYIGAEAASGLDHAHRKKGDDGTPLGIVHRDVSPQNVLLSNEGTVKVSDFGLVKAADNVLKTQSGVTIGKMSYMAPEQAQGIDVDARADVFALGVTIWEMLTIRSLIPPDDPQVAANLLRSGDFPPPSRFNPEVPPRLEKIVMQCLAIDPAARTPSAQQLAQDLRELLHERAAGYGRQQLARFLQWLFPEQGWELPEPERPPAQPSADERASFVPPTPVALAVARAEADAAAMPIEVAPPISPAAPAPSGSLPIVGGSSASHARVKAPLSALALSAMVGASAVIVLLAIAGVAWLVVRHASQSMPPEPASTAPPLQPLGAGVTIESPTAGVRLFLGPRELGAPPLRLTPEQLTGEPLVALAPRHQPLVIRAERLVELTRTVGRVHTVDLEPSQRPDWMVYVRYDGQGTAHLPEGDELGPVPGVVRVRTRRDLPTPDAIVIFDESGDHATSVSLEGCEADKVCVLYPPSGS
>NZ_CP011125.1|WP_075097428.1|600931_601501_+|nucleoside-deaminase
MTDSGDALPCSDVDASFMREAIAEARLAEAKGEVPVGCVIVLEGAIVGRGHNLRETMQDPTAHAEMIALRQAASTIGSWRLEHAIAYVTLEPCPMCAGALVNARVARVVYGADDPKAGATTTLYTIGSDPRLNHRFVLVPQVLGGECGALLTDFFGRIRAARRAARAGITPDVPPPPAKPRRDQEPEGG
>NZ_CP011125.1|WP_053230793.1|599888_600464_+|hypothetical-protein
MIRLSIAALIASACALLGVPRAHACSCVETPFEQLAAEADAIFEGRVASIEPAGEMHVRVRLDVVQTWREANAEHVEVRTASQSAACGVHFEVGRSYLVLAERADGEWTASLCGGTRAMEDADDERLSLGSGVIPVDIEDEETASTEQHPQTLPPRGGGCAGCAITSPAGSPIAPAIALVIAMWMRRRRIR
>NZ_CP011125.1|WP_053230791.1|597799_598879_+|NAD-dependent-epimerase/dehydratase-family-protein
MSAPTSACYDGAVKVVLTGATGFIGGAIARRLLDRGDELTVLARDPSAAASLAQRGANVATGSLLDPNAIARAARGADVLVHAAGIPSPRASARALRWTLVAGTENVLSAARHAGLERVVTISSADVTLANVDRVHWDEKRDLAQLPIGERARALRLAEEIALSTSDAELAVTALRPGWVWGPGDLSTLPELVREARSGGIRMFGDGRNLVATTYVDTLADAVIAAARAPGAPGQAYYVGDPEFLELREFLQQLSRTLTLPAPRPGPPFALVYPLAVLRAGRGGATLPEEILRRARSTLFDVQKAIAELDFRATISVDEGMKRLSSWVNEVGGLDAVLAKARPLPDEATLEREASAAGA
>NZ_CP011125.1|WP_053230790.1|595861_597772_-|hypothetical-protein
MRRFARVLALLLALGCDGSPPCVDEDLDGLGTHCEAGPDCDDGNAARGEDCDAVPAPDCTVDPTATGCPCLIGSVTDCFPGPSELAGVGECRTGRTRCVAQHWGLCDGSQGPSRERCDTLDQDCDGLADEGVRSPCGGCTASCTGELWGEPFDEAGGGLVVTGLGELTLAREERSSATVWAVNSAEATVSRIDAIEARETARYATGERDAVALEPSRVSVDWNGDAWVANRAFDGVPSVVRVAGDRARCVDRDASGTIETSASPEDVRAWGSDECVLASTIIGGAREVARAIAIDGDRGLDGVSGGDAWIGLHDGQAFVEVDGLRGDVIQRVETPGFSPYSAAFDPWGRLWAISRDGWLARIDPSADPPSLEIVEVPLACWLLYGMAIDGEGRIAMTGFSCDSVTIHDPRTSRWSTIRTEPSPRGAGFDGADLWVAHTGGRVSRLSLDPLRVVATRSLALDDVAPVDSIGIGADGLGHVWAISGAGGGAGLGVATRVDVEDAIAGAQVPVGASPHTQGDLAGLQLFGAPVPRASAQRVFDGCGADVTTSWVNVHVAGDPGTHGTIAIEVRHASDVASLASAPWISLGTIPDDAAPFPLALPEGGVIEVRVTLAVSASLGAPRLTRVGVEWTCPGPE
>NZ_CP011125.1|WP_053230789.1|594882_595761_-|tetratricopeptide-repeat-protein
MDRRRRGTLLASALIAAACALAPTTRASAQPPQGGGGGSESMSQATTTEGDMNDERARGAFRLGRQYYEQGRFADAASEFERAYGLSGRGQLLFNAYLAYRDARDDENAIRTLRGYLAQVEEIPDRALLEARLAALERGLAERREAEARAQAETDEARRQAEEARRQAEEAGRPRYREIPGETWPWIVMSGGGALIVAGIVTGAVALGERSALDEDCPLQLCPAGSDVEGRQSTIEALAITTDVLLVTGAAAAVTGLVLGLVLGPRTEAIETPPVSAACTGEGCFVAVRGDF
>NZ_CP011125.1|WP_075097429.1|610678_611872_-|TIGR04552-family-protein
MSIPPPAPPSDFRWLSDLRLAELESIRLILRGASVIDWQRLELASEAQVREFLAVQEFDLDDPASRARTEAVKNAAIAYLRRNFDFPIPKPVAQMDAAELLLLASARGHRQLCACTILKVMHIIHHLEARELLYMLPISDQDVFHLVEQKVYRVIGGMLAAGLPILEFIGGRKNRDSLYSKLLSKKETHAAQIYDKLRFRIVTRSPDDIFPVLSHLTRYLFPFNYVVPGQTTNTMFDLRKYCASSPHLAGLARELQPLVGEPDDDGLLVDNQFTSSSYRVVHFVVDMPVRLPQEILDLAPPAAWALGRVVFAQAEFQVIDRETEHANEMGDASHDAYKDRQKAAVMRRLKLGNVRPMVAPVPAALPVKAPEKRPAATRERGSRPPSSAAPTPKRKRK
>NZ_CP011125.1|WP_157068628.1|611903_612128_-|hypothetical-protein
MTATRSTKILPIALALAAAPMLGGCNGALIGNLVVLAVTVGIFFGTLGLGRASNAARSAASSTADRSSTQQPRS
>NZ_CP011125.1|WP_053230796.1|612399_614802_+|endopeptidase-La
MSATIPPPEGPEILPILPLRNSVLFPASVVPVNVGRARSVKLIEESFGRDRPTIGVVAQLVADVEDPEFEQVYELGTVARVLKVIRLSSGNYSVVLQGIARMRILEPQGRVPYMRARVQRIHEAPIRDTEIDALGAALRESARKLGELLPHQSREHALQLDNVSDAGALADLVATNLPVSTQQKQQILQILDVRERLRKVAELVSRQSQVYRVKKEISTMVQEEMSRSQREFLLRQQMKTIRRELGEAEDDDEIETLRERIARAHMPNDAEKAARKQLSRMRSMSPNGAEYQVCRNYVEWLADLPWSKTTADRLDVAEARRVLDEDHHGLDRIKRRIVEYIAVRRLKSDIRGPILCFVGPPGVGKTSLAKSIARATGRNFVRVALGGVQDEAEIRGHRRTYVGAYPGRFVAGLKNAGARNPVMLLDEIDKLGSDGRGDPASALLEVLDPEQNNTFTDHYLEVPVDLSPVLFIATANRKDTIPRPLLDRMELIELAGYTRDEKQAIAKNFLIPKQLEEHGLSPERLDFSDEAIDRLVDEYTREAGVRRLEQTIASVCRHVAVRLAEGEDVAQLADGAYVEKVLGPPRYDKQIAEKLGHAGVATGLAWTPAGGELMIVEASQMQGTGGIRVTGKVGDVMQESVAAAFTYIRARAESLGLAPDFLSKIDVHLHLPGGGIPKDGPSGGIAIFVAIASMLTQLKVRPDVGMTGEITLRGHVLPVSGIKEKCLAAHRAGLKHVLIPKRNEADLDEVPETIRKDLVIHLVSKVDEVLALVLELPSDGSPRPPSPPASSGPQEVATAS
>NZ_CP011125.1|WP_053230797.1|614814_617313_+|tetratricopeptide-repeat-protein
MSEQELASPSPRPIARFQGPVLGRKTARMALVVSVALAMLFVMLSPLTGVPGPESALVLGLILPPFVAAAGARLAIEARTSGLHRTGELLERATWLAGGCVALPTAILAINGLRVPWCAPWEGLAFVALGPGIGVLLAAFVGVAIGTLFQRPRLATTIAVLVPILAGLGSASLLYTSPAIYGYGHFFGYFPGTLYDPDIEIGTPYLTFRVLSGVQIGGFVALILAGVDPRTARISGRYARTRVGSLIIATSFFAAALYGEYRATDLGHRSTADSIAQRLGTTLHGRICDVVVPRELARARAERLRDDCDLRVEQTAQGLGVEQRERVTAFFFRSTSEKRELMGASGTYIAKPWRNEVYLQLSGWPHPVLAHEIVHVVAGNAGVGPFRISGTLGGWLPSPGIIEGIAVALSWEERDGLTPHQWARAMMALEMMPRVSQTEGLGFLLQPASRAYVTSGSFVRWILDTRGSEVVRAISRAGEYEGALGMPLEEAERAWREYLRTEVPLPPEALAMAEARFERPAIFAQVCPHRVAALMDMVADDLAAGDDRHAAETCEEVLDIDPNDTRARAWMAVALAREGELARARRELDRLIGPPSASRPVIRAARQGIADALWAQGNVEEAAVMYRAILHEPLGDEEARQIEVRLLAVESGLPGGEHLREVFAPDPDEPHDAVTAMQAIMRLRELRPDGLGAYLEARQMIQRERFDRAEEALREAQSRGLPSERLSREARRMRAITEFAMGRRRRARALWEDVLEDPSASEAARVEALDWIDRIERAGETTEPIEGEETRVEDAAALPEPTDVVVPDVDAHPMPPAVQQTELPVTEGLAPP
>NZ_CP011125.1|WP_053230798.1|617413_618223_+|hypothetical-protein
MASWIDPTRGRALAVLALVLSASCLGETAASHVTRVPTLAWAVASSVAIVLVAGAVTARRREIAKVVIASPFFTFELLTYRQAVRGIGLAVMVLVTDVVLGRDAMRWLLGPLVIACALASETRRDQSASLEHWLHRLAGKWLAPREGEAVLVRLAMSAALAACVGRVLGASVAARVWVAACGLFAVVLGLWCVERACTIARMRVVGGDDPRAPRLLPGEPVALVVARETSPYRDRAVIGAVPERARLVATTMAITSGVAAVLGAIAMLA
>NZ_CP011125.1|WP_169791305.1|618226_620596_-|hypothetical-protein
MLGPARTFPSLLLMVLVGACAEPRTSDDAGSLPVRDTGVIEDASTPDDDAQPAEHDAAREDASTPACDEDSDCDDGLFCNGVEHCDSYEGARYCNSPWERPCGLAPCDEAADRCCVDEDHDGYPAAGCTVPDVRIDCDDTDYQVHPLRAEPCGGRDEDCDPETFGYDGDADYDGHARTDCCQEALDGTVRCGDDCDDDDGATYPGAAERCDARDDDCDAAIDEGLASSAETWVADCDVDGFGDRTRGVLACGPPAGAGPPTCPWGYWSYDGEPDCDDDAYDVHPSGDEWTCDGRDDDCDGAIDRTEIDRDGDGFVGFACDSTHDCDDGDPSVRPGAIELCNDRDDDCDPSTIDDADGDGHAGIDAVCAGGSLPRDDCDDRRYETHPGGFERCNGLDDDCDGSIDGTSAYCFARDATRTECRDGQCFELACRDGRGLCLDPDHCTTDTANDEAHCGDCGTRCTSSACVMGACGAFDALALTSAGTIALVGGEPLLVGVSGATRTGDIASLAARAIGGGARACVAWSNDRVTCPRDSALVPGTVEVGAAEGFACARTGAGRVWCWGTGATGELGDGALHPAPSGPFAVAGLEDARAIAVGARSTCALRASGGVACWGHGHFGTLGDGTTAIAPAPVAAALTGSALAIAAGDWHVCAIDDARRVWCWGSNARGQLGLGAPGGTRTTPQLVSSIEDAVAIAAAGESTCAVRASGALVCWGANDSGQLGDGTRVDRATPVVVDETIASVWMGRAHACSRSTSGVVTCWGENDDGRLGDGTTTDALRPTVLDYTP
>NZ_CP011125.1|WP_169791306.1|620660_621920_+|hypothetical-protein
MRGPSKLRAALVTLAIALLGCAESDRTGALAEPCSESGACDEGLVCERGVCALPAIAQDASAPREDASVVEEHDAGTPVDASGWDATLVPPEPPPPPRDTGPRLPPPPLRSHTAEPGFFDAALDWERHRLFLSQGASGRVEVIDLVTGARGIVNTGHIAEHMHFDPHRDEIAIALPVRLHSSYWWDDEQEGYVTTIDPAALTVREPIYVEIDPWDVIADGYGRIHVSSGSGQHTISATIDLVQGQSRVLTDSFGLYERTSLELHPSGDHAYGVGPHDATARLELGSVLAIQYRAPHDPSMPTACAAIRIDPRGRTIHTACGQVLVATDNPLTDMTPTGTLDTGWTDLVFHPSGDRLYLIDDDAPGIGVYDVATLTRVDTIDVEGRPVRLLAAPDYLVVLTPVLGGVPTTRVDVRSYDAR
>NZ_CP011125.1|WP_053230801.1|621909_623226_+|hypothetical-protein
MRADRPILAAILLAACSGATPDLGALAAPCAYDGSCRGALVCERGICVLPVDAARAVMDASTPDAGAHELDAQVDTPTIDAHVQLDANAPVDANAPVDAGLDAYAGWDATLAEPVPAPPPPADTGPIEPAPTPRTCTVPGHGVDHELDWERHILVASMRSDRAVHLVDLATCEVRTHALDARPERIHFDPHRDEHLITAVVGTPGDFDEAGALHRIDASSGAMDTPIALTVDPFGVVADGRGSAYLSRARSASLSLVTVDLETGAAQLERSVLFSGGAVFALHPARDRAYSISAGVVPQDLARVELGSSTGTSYDSPYHGQYELCGDLRVDPRGRTIHTACGEVFLASDVAATDMTWVGSLGRAWIDLAFHPDGEHAYVLGDTPDVDVYDVATLARVRSVPLARRARRVFVTRDYVVLVYELDSPSSTRIEVRALDSL
>NZ_CP011125.1|WP_157068629.1|623230_625144_-|VWA-domain-containing-protein
MRIDDGLRFVLAIAVAASAPGCVMYARVPLVRAGAGWSAPAGPTYVVEQPAMGAACASAGPCAPGGVVVVEDTTARASTTTIASAGGASGVVIVESAGYAGESGIVVAGGDASASGVVVTSGDASASGVVATGGDASASGVVVTGGDASASSGGVLVAAGDASSAGALVGGADASASVAGGDASASGGVAITGQGRGLLAIANEGVTIDGAIAALGLLGPLAGSSFDASTRVGGDGSITIDASLAHDALPGAGGQTSVVVRVAGGHAPSRVPPLRVHLVIDASTSMQSTWAHLQEAALHLVARLRPEDELQIVVYGTDAREALAPVRVGDGSSARRVIRALRPDGRTNIEAGLRIAYREVRPHASLVVVLSDGVPNGGLSTPDELGALSAEANARGAVTTAIGIGWDFHPGILRALAERGRGRFRIAPRAGELGAILEAELAARGRVAAHDIDVSIALGAGVRIDGELPAGVVRTEGGVRIAAPSIASGEEQVVVVPVMVPPGTDARAIARIDARWTPAGAGVAQHADKALAVAVSRTPVLAGGALAALDADLSASLALAAEAVTNGDAHAASVALRDHAVRARVQVRARRDVALEARAGHVETLAIALERLVPSASWHDRRALGASMLSFSVSLGR
>NZ_CP011125.1|WP_053230803.1|625255_626011_-|hypothetical-protein
MARRKDDDSKGDPRAPKPPRPQGSRERDMGVVRRRPDDPRKRLPSELEAFARGDDDALWRRERSRGRVNDPRPVAATLVPGVANRDARIVCDARIKRLRSAIDAGDEYVLAEELADAVRLGVWRGHKIVDFDVFAEAVLGLGIDRARALAQQGAAALDVPCEIADEQTVALWMRAESGLLEHAPESRVSLRGGRLVLEVPFARAAEALSGVGRRAAPLAKPQGGPDVVVDRPKGVPPLSRLIERDRPRDDE

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Crispr_ID: NZ_CP011125_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_4

782663-782811

Orphan

Consensus_repeat	Method
ACCGACCGTGGTTGAGGTTTTCCTCA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP011125_4

>merge|NZ_CP011125|4|782663-782811|CRISPRCasFinder
ACCGACCGTGGTTGAGGTTTTCCTCAATGTTTTCGCGGTACGGACCGAGCTGATGGACAGTGCGGGACCGACCGTGGTTGAGGTTTTCGTCAGTCGTGGCGCGGCACCGCCGCGAAGCCACAGACCGACCGTGGTTGACGCCTTCTCAA

>NZ_CP011125|4|3|782663-782811|CRISPRCasFinder
ACCGACCGTGGTTGAGGTTTTCCTCA	ATGTTTTCGCGGTACGGACCGAGCTGATGGACAGTGCGGG
ACCGACCGTGGTTGAGGTTTTCGTCA	GTCGTGGCGCGGCACCGCCGCGAAGCCACAG
ACCGACCGTGGTTGACGCCTTCTCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053230923.1\|770932_771346_-\|photoactive-yellow-protein	unknown	unknown	gnl\|CDD\|131426
NZ_CP011125.1\|WP_157068670.1\|791221_791392_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791316.1\|771385_772759_-\|fasciclin-domain-containing-protein	unknown	unknown	gnl\|CDD\|367095
NZ_CP011125.1\|WP_053238663.1\|790025_791141_-\|tryptophan-2,3-dioxygenase	unknown	unknown	gnl\|CDD\|226014
NZ_CP011125.1\|WP_053230936.1\|785668_786757_+\|NADH:flavin-oxidoreductase	unknown	unknown	gnl\|CDD\|239201
NZ_CP011125.1\|WP_157068666.1\|784079_785138_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187552
NZ_CP011125.1\|WP_053230935.1\|785138_785615_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157068669.1\|789026_789860_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157068667.1\|786757_787138_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157068665.1\|782858_783986_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|338048
NZ_CP011125.1\|WP_157068664.1\|772972_775525_-\|penicillin-acylase-family-protein	unknown	unknown	gnl\|CDD\|376618
NZ_CP011125.1\|WP_053230932.1\|781602_782583_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053230940.1\|791480_792959_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230929.1\|779366_779762_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230926.1\|775624_776005_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237616
NZ_CP011125.1\|WP_053230928.1\|778780_779176_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP011125.1\|WP_169791317.1\|777587_778760_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223652
NZ_CP011125.1\|WP_053230927.1\|776014_777541_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157068668.1\|787742_788891_+\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|379142
NZ_CP011125.1\|WP_053230930.1\|779936_780899_-\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|366736

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053230923.1\|770932_771346_-\|photoactive-yellow-protein	gnl\|CDD\|131426	TIGR02373, Photoactive_yellow_protein, photoactive yellow protein. Members of this family are photoactive yellow protein, a cytosolic, 14-kDa light-sensing protein which has a 4-hydroxycinnamyl (p-coumaric acid) chromophore covalently linked to a Cys residue. The enzyme 4-coumarate--CoA ligase as described by TIGR02372 is required for its biosynthesis. The modified Cys is in a PAS (pfam00989) domain, frequently found in signal transducing proteins. Members are known in alpha and gamma Proteobacteria that include Rhodobacter capsulatus, Halorhodospira halophila, Rhodospirillum centenum, etc.	9.94851e-51
NZ_CP011125.1\|WP_169791316.1\|771385_772759_-\|fasciclin-domain-containing-protein	gnl\|CDD\|367095	pfam02469, Fasciclin, Fasciclin domain. This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.	7.00104e-28
NZ_CP011125.1\|WP_053238663.1\|790025_791141_-\|tryptophan-2,3-dioxygenase	gnl\|CDD\|226014	COG3483, TDO2, Tryptophan 2,3-dioxygenase (vermilion) [Amino acid transport and metabolism].	1.75551e-59
NZ_CP011125.1\|WP_053230936.1\|785668_786757_+\|NADH:flavin-oxidoreductase	gnl\|CDD\|239201	cd02803, OYE_like_FMN_family, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	1.13992e-114
NZ_CP011125.1\|WP_157068666.1\|784079_785138_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187552	cd05241, 3b-HSD-like_SDR_e, 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs. Extended SDR family domains belonging to this subgroup have the characteristic active site tetrad and a fairly well-conserved NAD(P)-binding motif. 3b-HSD catalyzes the NAD-dependent conversion of various steroids, such as pregnenolone to progesterone, or androstenediol to testosterone. This subgroup includes an unusual bifunctional 3b-HSD/C-4 decarboxylase from Arabidopsis thaliana, and Saccharomyces cerevisiae ERG26, a 3b-HSD/C-4 decarboxylase, involved in the synthesis of ergosterol, the major sterol of yeast. It also includes human 3 beta-HSD/HSD3B1 and C(27) 3beta-HSD/ [3beta-hydroxy-delta(5)-C(27)-steroid oxidoreductase; HSD3B7]. C(27) 3beta-HSD/HSD3B7 is a membrane-bound enzyme of the endoplasmic reticulum, that catalyzes the isomerization and oxidation of 7alpha-hydroxylated sterol intermediates, an early step in bile acid biosynthesis. Mutations in the human NSDHL (NAD(P)H steroid dehydrogenase-like protein) cause CHILD syndrome (congenital hemidysplasia with ichthyosiform nevus and limb defects), an X-linked dominant, male-lethal trait. Mutations in the human gene encoding C(27) 3beta-HSD underlie a rare autosomal recessive form of neonatal cholestasis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid sythase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.37888e-81
NZ_CP011125.1\|WP_157068665.1\|782858_783986_-\|hypothetical-protein	gnl\|CDD\|338048	pfam11617, Cu-binding_MopE, Putative metal-binding motif. The seqeunce of structure 2vov is not matched in any other sequence either in UniProt or in NCBI (Sep2014). The model is of a short repeat not found on the G1UBC6 - 2vov - protein. The presence of conserved cysteine residues and the lack of hydrophobic residues suggests that this repeat might be a metal-binding site, perhaps for zinc or calcium ions.	0.000215809
NZ_CP011125.1\|WP_157068664.1\|772972_775525_-\|penicillin-acylase-family-protein	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	7.25688e-134
NZ_CP011125.1\|WP_053230932.1\|781602_782583_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.63555e-89
NZ_CP011125.1\|WP_053230926.1\|775624_776005_-\|hypothetical-protein	gnl\|CDD\|237616	PRK14127, PRK14127, cell division regulator GpsB.	0.00498162
NZ_CP011125.1\|WP_053230928.1\|778780_779176_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	8.49994e-29
NZ_CP011125.1\|WP_169791317.1\|777587_778760_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223652	COG0579, COG0579, Predicted dehydrogenase [General function prediction only].	3.42413e-101
NZ_CP011125.1\|WP_157068668.1\|787742_788891_+\|trypsin-like-serine-protease	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	0.00843064
NZ_CP011125.1\|WP_053230930.1\|779936_780899_-\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	2.77812e-08

>NZ_CP011125.1|WP_053230932.1|781602_782583_+|serine/threonine-protein-kinase
MAASGKRDDEWMGQAPSRDTMVDAVPTGALEAPPSGERIGAIVAGRYRVERLLGSGAHAAVFGGVDQHTGDAVAVKVLHDRLAHDRDHVARLLHEAEIMREIAHPGVVRVMGAGQDEGGRWYIAIELLEGEDLATAIERGPLDAALVVEIGHQLLATLAAAHARGIIHRDVKPENVFLARDELGSLRVKLLDFGVAKSIEARASSPVHRTHDGVKIGTPHYMSPEQWAGMPLDARSDVWAAAAVLFTATVGVPPFDAEDLGTLMTRVTETDAPSLAALRPEIGPAFVDTIDRALATDPADRWVDARAMAAALHVGGARVDALDWDE
>NZ_CP011125.1|WP_053230930.1|779936_780899_-|aminoglycoside-phosphotransferase-family-protein
MIEPERAAPQLPHVRRTRMLGMLACVTAPAAPSIDVVMRETRALVRELGLAQVEPNVIADRSNLVLHLAPHPLVARVAMATSMVRVGMQWLRREVEISRFLDGRGAFVTRPSTTIDPGPFDRAGLVISVWDLETIDARAVDPRRAGARLAGAHRLLASSDAPALPEWGGWAEARAVLERARTSGAWSASEAHRVASAWERAERIVESARARTASFQPVHGDAHVGNVLATSRGPVWTDWEDAFVGPVEWDLACLRSKAELFGEERETIDAITAAYDAPYDAELARELGLVRNLQVIPWLAVFAERDPSLLPRMRARIEAL
>NZ_CP011125.1|WP_053230929.1|779366_779762_+|hypothetical-protein
MPNSRLQLSTAARPQFDRRNDRGLLAVLALTPGLLLTLAIATFVVAGASSEAGLVLLASHVITQFIVLLIYGALLVEDEGLDPLGRALFAITFLFGAPVALPVYYLLRVLIPAGPEARGWALAISPKVVPA
>NZ_CP011125.1|WP_053230928.1|778780_779176_+|PaaI-family-thioesterase
MDDLLASSRFASWLGLRIVSRSDGACRIELPIRDEHANTRGIAHGGVIASLIDTAAGAAIALQPSIDGQGVVTVSLATSYLAPAQVGDVLVAEARRRSGGKRVVVCEVEVTSTKGDAIATALVTLAAAKPV
>NZ_CP011125.1|WP_169791317.1|777587_778760_-|NAD(P)/FAD-dependent-oxidoreductase
MRRAHDDHASRVSQRELRVRFDAIVIGAGVVGLACAERLARDGRRVLVIERHPTFGRETSSRNSQVVHAGLYYPRGSLKARLCVAGRHALVAWCTQHGIALRAIGKLVVAVDDDELASLHALRDRALENGVDDVVILDGDEMRRREPDVIANAALWSPSSGIVDAHGVMASLLAVARGHRALDVAFRHEVVHADRVADGYVLRVRDDSHRETDVRATVVVNAAGLEADTIAARVGIDVDDARYRQRWVKGSYCALRRGALRVRSLVYPMPPASLVGLGVHLTLELDGTLRLGPDVEPLSARIADHTVRDELAPRFHAAASRFVRGLARDDVTPDRAGIRPKLIARDGEVRDFVIAEESSRGLAGWVDLIGIESPGLTASLAIAGEVARIV
>NZ_CP011125.1|WP_053230927.1|776014_777541_-|hypothetical-protein
MNVRSLFVISMLALSLVACGDDDDGTGTPDAGAMDAGSSDAGTDANVGDDAGTDGDLMRDFCEPLADLVCTRAAASECGCGAALPGGEVDVEGCTARFAAQCATSWAPLATGDARVDADAAAECVALIGSSTTGCQLPPATGIVIAHCTPFVYGPAAIDAACTSPLCAEGAGLCAGGTCRARGGAGATCSPEQPFQCAVGLVCRGGECVTPPTSGQPCEENGQCALGLRCVEGMCLMLGAAASACDATSECGEALLCSEGGTCIARDHETCSPEDACGNLQTCRAPRACAPRGVAGATCTESRDCAPALFCSDESRTCVARPTEGQPCAPGNVCALGLGCDMDGGGTCRPLPTAGQPCAYRDGDTPFVCAGDLACVDNECAAAPGEGEPCAFGNVCATGLACDFTREGSFCIVPRVGGGECMSDRSCADAFHCGPENTCVADLPSGSTCRAGNECAGVCVPSASGGFVCADRPDEGETCLFDEDCGDALVCDPVASAARCGGEICAVL
>NZ_CP011125.1|WP_053230926.1|775624_776005_-|hypothetical-protein
MHDRIAELEREIESLRARLDALAEQGAPGRTSLRIHRRCPVCDHRSVLRIERIADRSQGAIEALAPLIQPGFLEQKALGQFVVYVCRQCGLAEWYVARIEEIPLDHPSVRVAEGPPKPPEGSGPFR
>NZ_CP011125.1|WP_157068664.1|772972_775525_-|penicillin-acylase-family-protein
MERHSIARFALALALLGGCGDDTRVAPPTEAQCDADPLLPGCTPDERPTFAGLDDEVAILRDDMGVAHVYAQSDRDAFYASGYMQAFDRLLQMDLNRRRALGRRAEVLGESYVDEDELSRLFDLPRWARTNEAALFRDDPERWALVQAWTEGVNARIREVLADRSQLPPEFEELGYEPEEWTPVDAFAFGKLVLFGNANQLESSILSAILDEYLPELDGRLGLLLPIRDAYVMPPDERPATARAIVRPSAPRTPRALPPDALERIARFQSTMADFRSGGSNNWALDGRHTANGRPLIAGDPHQPLQSPSLFWLHHMNSADAGGALDVVGFNFVGSPGVQLGHNRHVAWTATTTYPDNMDVWDVAIGPGGGVMIGDEEVAIVTRTETIAVAGANTVEYVVEDVPGHGVLLPSGLSPLPLGRPGRRLLVNWTGLRVTHEFEGFFGFGTARDTDEFAAAVEGVELGYFNFVFADANGIRYHSQPLVPDRGVIGARRPWALSDGDDASTFWRDRWLDRARMPSSTGGARGWITSANNDPFGFVADGRVDTDPWYFGVLYDPGLRAARIEQELERLIARGDVTVEDMQVLQDDTHSIIADDLVPVLEEVWATVETDDALAEWRGRDDLDALVVSLAAWDRRMERTSSEAVVLNAFSYFLAQRVLADDMTIVFDAVMSESSAFIFKWLSNVLRGRAPDSESFFAGEARSVSVVRALDETAAWLAERFPGGSYTWGDVHGTRFPSLYGERLDGGWVATDGAEGTVNVSVTDFFGDGDAPRERLEASSGSIYRLVATFGDDGTPEAFVNVPRGVSGDPESAHWSDLHTDWIENVYRPLRFRRSDIEAGEHERMTLSPQ
>NZ_CP011125.1|WP_169791316.1|771385_772759_-|fasciclin-domain-containing-protein
MTLLLSKRAPRAALLALVLGGLWACGDDDGGGDSDAGRADAGTDAGSGDTIADIAAASDDFDVLVAAASRAGLVDTLSGTAEFTVFAPTDAAFVALLDVADEAAAIAAVEALGPETLAGILTYHALSGTVTSSELEDGPATTVSTLPVFVGTGATVTINGGNGVDGGANVTTADIAASNGVIHVIDRVLVPPTVADVARYAGLTTLAGALASQELVDDLEAAGPFTVFAPTNAAFSALGALPSGGALTTVLLHHVVSGSVASSAIPARASSLAESSYGDPLTLLFDDGDGVVINGAAEVVIADLRATNGVVHVVDAVITPMNVVQAASAAGLTGLLGAVEAAADLPGGTSVADALAADAPYTVFAPTNDAFAALSPTPDADTLRDVLLYHVLSTDSFDSPVLSTELPTTATGLETLNGADIPFVPGPPATVDGAEIVIADIVVTNGVVHVIDTVMLP
>NZ_CP011125.1|WP_053230923.1|770932_771346_-|photoactive-yellow-protein
MEFTRLSFDQDDVANVLAKLPPSQLDELPFGAIELDANGRILQYNATESKLSGRAVESVIGRLFFDEVAPCTRRPEFYGRFLELVKGGPSAVFDYVFDYKMRPRQVRVHMKRALLGKTYWILVRWNDGAGRSVAGGV
>NZ_CP011125.1|WP_157068665.1|782858_783986_-|hypothetical-protein
MRPFVDRIASVLVALTLIPTTACSILVDPDETRLGEQSGIDAGAPPDAPGVQCDLDCDDGIVCTVDRCLDGACVHQRDDGACGGPGDACVGIRTCDPPRSTNESGCVFGAPLVCDDGVACTDDECDPATGACRFEADHGACDDGIDCTLDLCDPSRGGDGCTHTADDTICDDGFCRSGGRCDPARGCTGGTARDCSDTSRCTDDRCDEVLAMCVRTAVDADGDGFTAQRVLGESCIDGTDCDDARSGVHPGATEVCSNAIDDDCDGAPDDGCSACRPMPSVCPTGWTYSNDGRDHTCSVSFTPPFGVREYCRYAEEGVLGFYWMLAVPYSCPSGARYAPNAATGYCLWERLTLPAASTIDCSAVGSGRMSFRWPC
>NZ_CP011125.1|WP_157068666.1|784079_785138_+|NAD-dependent-epimerase/dehydratase-family-protein
MSRSAVVIGGSGFVGRRLVEMLAGEPGVDRPQSWPRFDSVHVVDVAPWRSDVALATKVTSSIADVRSRDALREVLRGAHTVFHLASLVDVGLKKNPTIDAVNVDGARNVVEVCRELGVPFVVYTSTEDVVLRDTPIAHGDESLPYPEVPLHDYVRTKIEGERIVLAADRRDGLRTCAVRPVHVYGPNDPHAIVTTLRAFASGSVPVLLGDGRARFDVVYVDNVVHAHLLAAAKLHDPATRDVVGGRAYFVGEGNAPNYFEFLRPYAEVKGIRMPRRWLGRRRTALAARVLEGVHRLTGADVPFHRFHVHVICEDFFFSCARAERELGYRPHVAPSEGLRRTIEWVRDVRLEA
>NZ_CP011125.1|WP_053230935.1|785138_785615_-|hypothetical-protein
MRTIAELIEADESVAFGACGRVVIMVWTGVATRERLERSAEIVVAHAARGGPIGIISVVEHGAPIPAPESIEIAVDRIVAAAPELAGSAFVIEGGGDWAMAVLDVASTAHRRHHDVLVRKYCHDTREASAWLTARCGGAPTRAELVDAIEIVRAALVR
>NZ_CP011125.1|WP_053230936.1|785668_786757_+|NADH:flavin-oxidoreductase
MSNPLLLSPVVLRPGVVAPNRVWLAPLTNMQSHPDGTLSDDELAFLARRADGGFGLIETCAAHVSQDGKAWPGELGVHDDAMVPGLRRLAARIKQAGALASVQLFHGGLRATPSVSGVPTWSASAHEEPGTITPRAGTEEDIARVIAHFASAARRCAEAGFDAIELHGAHGYLLSQFLSSVYNRRADRWGGPLENRARLIREVLRAVRAAAPSLVLAVRLSPEDFGQAKGIDLDETIEVARWLAADGMEVLHLSLWRSALTTKKRPESHATTLFREALGARVKIVVAGQIWTREEGEAQLANGADAIALGRSAIANPEWPRIVHGLEQGELRTPPVTEDELRARALSEGFVRYMRNWKGFVA
>NZ_CP011125.1|WP_157068667.1|786757_787138_-|hypothetical-protein
MHIARDMTGWGIDSHNTIDRARIEARARRMGTAVRTAYDAFDRCARSGRGELERAWHELDDRVQDLAIITALLPAHHVVRLAAEHVRIAHARWTEDPDAERLPIALALALLDRALSETDRGLDRAA
>NZ_CP011125.1|WP_157068668.1|787742_788891_+|trypsin-like-serine-protease
MLSFAANGQVGFCTAALIAPDRIVIAAHCAPDGTPGPTASLHYFLPDEHAVTLAWSAVTAVVHREDRNVGADHAVLLLHREIDAPHLALARVPPAPEGRFDVVRASPHSDGTVFVRREQCLVMPQALSADRIVPSAIARIAGCTIVPGNSGSPMLDDSGRVVAVVSTGLAPPGVAVLLAPWLTGPAPFVGTLSSLACLPTDVGPGAAPGACVAWSRTPDGGLVSSAEARDAAIDVQREALAERLLEWERADVASRDLVGWDLDSRVRGDRTWALPVPGCLDVAELERTGRIDSRGRFRLSVQVPAWQASAFVFGFDLRMVPITERVGSVWMDVTGRFDEVRDIATIRVRVRGARVFRPRRDAHVPACRDAEEPPSAVPSNGV
>NZ_CP011125.1|WP_157068669.1|789026_789860_-|hypothetical-protein
MIRAPELPKLEHRLAELRRSASTDGKGRIPFPDWLVAPSALVRHDRLTATRTEERGASRSDFGPRFALLARDLFLDRSAHLLGAPAARDARERAELELDRLRPLLVLWVEEHRRTTRLQHTASDVARSRLYSRPLSGFSHESGEHRIRNGIGALLHDRVTRTEHDDRRGLVIPNRALPSAKDLRPERDPAMQIAQEIRENAGDVGDDEVLVRAHQRRDVDDDPVFARGHCERVNEQAPHLLVGAKEMMTTKGAARDQDGGAWEDDAWLCHAAALSND
>NZ_CP011125.1|WP_053238663.1|790025_791141_-|tryptophan-2,3-dioxygenase
MARKATTYWDYIKVEEITSLQGGLEESDAGLSNDEVLFITVHQIDELWLKLALRELVSVRGLFAQERVPEQSLASAVRGLRRMALLFHHIAQHFALMETMTTRDYLAFRDKLSPASGFQSAQLREIEILMGLRDSDRIALGHEHGYMQALRAPDGSESAASRRVSARLADRPTLREALDEWLFRTPIQGSTPDRAGDAETVKRFVEQYLEAHAGEVRRAQELAMHDALTPHDAERLRARYEKEVGGARAFLEAVDAPEEERARRARVRAALMFIESYRELPLLAWPREVIDAIVAIEQAFVIFRQRHARMVERVIGRRTGTGGSAGVDYLDQTALRYRIFHDVWAVRTLLIRAQALPPVETPDAYTLGVGQ
>NZ_CP011125.1|WP_157068670.1|791221_791392_+|hypothetical-protein
MAVRVPSQASTKWWILLAAVLAALLTYWQHRDAIERAPSRPPAPQSDFVEVEIVAE
>NZ_CP011125.1|WP_053230940.1|791480_792959_+|hypothetical-protein
MPTSSLISRSALIVLLASVALAPARTSAQATAIRSVRTVLAPWDREGTETLDAMRELTRTARSAPTPEARLEARYLRASIAIDLLIASQLGAERAIPVARIADTLGVAEPELEPHLRSELGAVVSSVAYRDPAREALSALDLRAAMARGDREIDWSRHQGSRRDLLLVATATEALGISGDPAQLPAFAPEPCATATPSTPCSAPWTSLAPASRRELASMLEVSRALKRIGDRARAGDPLSRALQDRVALATARLETTTLHAIPRLERDRDLLGGEDGEPVRASVIVLVRRREVRVASMPPLRVRDGEIVLPADAGRVLPESDSVRLPWRFAGPPAAITEVARAVGAHRPDRRTVAVAVAPRVRADVLARVLVSVAEIARGPIALVRRGADGTLRGAPITIVMHDRDVSRRDLVVNVDSGRYALARRQRRITLRLPDVRPQSGIGFGHLDSLIQRLPHQRVVVGARPDVPARDLLDVAFRAIVAHDTLAVRVR

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Crispr_ID: NZ_CP011125_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_5

871993-872128

Orphan

Consensus_repeat	Method
CGACACCGACTCGGGCTCGATC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP011125_5

>merge|NZ_CP011125|5|871993-872128|PILER-CR
CGACACCGACTCGGGCTCGATCGATGGATCGTTCGGAGGCCACGGCGAGCTCTCGGCGGACTCGGGCTCGCTCGAGCTCGAGCTCACGACGCCGCTCGACGGCGACGTGATCCTCGGCACCGACTCGGGCTCGATC

>NZ_CP011125|5|2|871993-872128|PILER-CR
CGACACCGACTCGGGCTCGATC	GATGGATCGTTCGGAGGCCACGGCGAGCTCTCGGCG
GACTCGGGCTCGCTCGAGCTCG	AGCTCACGACGCCGCTCGACGGCGACGTGATCCTCGGCACCGAC
TCGGGCTCGATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_157068679.1\|875894_877049_+\|enterochelin-esterase	unknown	unknown	gnl\|CDD\|225256
NZ_CP011125.1\|WP_157068680.1\|878764_879532_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227505
NZ_CP011125.1\|WP_053230986.1\|858093_858723_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176908
NZ_CP011125.1\|WP_053230995.1\|872986_873703_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157068678.1\|874929_875904_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153240
NZ_CP011125.1\|WP_157068676.1\|854305_855118_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238668.1\|862170_863394_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|237195
NZ_CP011125.1\|WP_075097437.1\|855296_857891_+\|phosphodiester-glycosidase-family-protein	unknown	unknown	gnl\|CDD\|378342
NZ_CP011125.1\|WP_169791323.1\|879532_880828_-\|peptidoglycan-recognition-protein	unknown	unknown	gnl\|CDD\|128941
NZ_CP011125.1\|WP_053230996.1\|873699_874857_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236766
NZ_CP011125.1\|WP_053231002.1\|881048_881957_+\|sterol-desaturase-family-protein	unknown	unknown	gnl\|CDD\|225546
NZ_CP011125.1\|WP_053230983.1\|852499_854041_+\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|223104
NZ_CP011125.1\|WP_083458455.1\|872369_872990_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NZ_CP011125.1\|WP_053230999.1\|878423_878726_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230990.1\|863540_869864_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_CP011125.1\|WP_075097808.1\|877185_878427_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223516
NZ_CP011125.1\|WP_157068677.1\|858885_860238_+\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NZ_CP011125.1\|WP_053230989.1\|860420_862118_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230991.1\|869872_870508_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053230992.1\|870612_871371_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236766

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_157068679.1\|875894_877049_+\|enterochelin-esterase	gnl\|CDD\|225256	COG2382, Fes, Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism].	4.47949e-32
NZ_CP011125.1\|WP_157068680.1\|878764_879532_+\|hypothetical-protein	gnl\|CDD\|227505	COG5178, PRP8, U5 snRNP spliceosome subunit [RNA processing and modification].	1.29809e-06
NZ_CP011125.1\|WP_053230986.1\|858093_858723_-\|SRPBCC-family-protein	gnl\|CDD\|176908	cd08899, SRPBCC_CalC_Aha1-like_6, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	1.2263e-38
NZ_CP011125.1\|WP_075097808.1\|877185_878427_+\|hypothetical-protein	gnl\|CDD\|223516	COG0439, AccC, Biotin carboxylase [Lipid metabolism].	3.71534e-07
NZ_CP011125.1\|WP_157068678.1\|874929_875904_+\|hypothetical-protein	gnl\|CDD\|153240	cd03146, GAT1_Peptidase_E, Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E. Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E. This group contains proteins similar to the aspartyl dipeptidases Salmonella typhimurium peptidase E and Xenopus laevis peptidase E. In bacteria peptidase E is believed to play a role in degrading peptides generated by intracellular protein breakdown or imported into the cell as nutrient sources. Peptidase E uniquely hydrolyses only Asp-X dipeptides (where X is any amino acid), and one tripeptide Asp-Gly-Gly. Peptidase E is believed to be a serine peptidase having a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad typical of GATase1 domains by having a Ser in place of the reactive Cys at the nucleophile elbow. Xenopus PepE is developmentally regulated in response to thyroid hormone and, it is thought to play a role in apoptosis during tail reabsorption.	0.0028652
NZ_CP011125.1\|WP_169791323.1\|879532_880828_-\|peptidoglycan-recognition-protein	gnl\|CDD\|128941	smart00701, PGRP, Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine.	9.1782e-38
NZ_CP011125.1\|WP_053238668.1\|862170_863394_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|237195	PRK12767, PRK12767, carbamoyl phosphate synthase-like protein; Provisional.	7.72935e-15
NZ_CP011125.1\|WP_053230996.1\|873699_874857_+\|hypothetical-protein	gnl\|CDD\|236766	PRK10811, rne, ribonuclease E; Reviewed.	7.8913e-06
NZ_CP011125.1\|WP_053231002.1\|881048_881957_+\|sterol-desaturase-family-protein	gnl\|CDD\|225546	COG3000, ERG3, Sterol desaturase [Lipid metabolism].	8.57165e-16
NZ_CP011125.1\|WP_053230983.1\|852499_854041_+\|sodium:proton-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	1.19338e-59
NZ_CP011125.1\|WP_083458455.1\|872369_872990_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	4.52417e-31
NZ_CP011125.1\|WP_075097437.1\|855296_857891_+\|phosphodiester-glycosidase-family-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	8.34674e-29
NZ_CP011125.1\|WP_053230990.1\|863540_869864_+\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	2.91532e-35
NZ_CP011125.1\|WP_157068677.1\|858885_860238_+\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	7.3355e-07
NZ_CP011125.1\|WP_053230992.1\|870612_871371_+\|hypothetical-protein	gnl\|CDD\|236766	PRK10811, rne, ribonuclease E; Reviewed.	1.04212e-06

>NZ_CP011125.1|WP_053230992.1|870612_871371_+|hypothetical-protein
MTRHLSLFVSALVLALAVTPRALAQDVVIIVPAEPTPPASEPIAPAPVVVEAAPPVEPTLVVEPAPVVEAAPVVEAAPVVEAAPEPEPDVFAPGFFSIGLSGLVGLRDAPHHEIAPTWTAGLDLGFRVLPWLSVSARRVGYSHASTLVGDRHAISVSPALELTMPLWERVQPYAQVGAGVQARFGGSQGRTVGFAPFIGGGVRFFVAEIFSIAVESAMHVPVTEDGFLFGNEVLPQGAVVLQGGLAFAFHID
>NZ_CP011125.1|WP_053230991.1|869872_870508_-|hypothetical-protein
MRTSIRALAPLIVALGLCAPAAAQEHERPPASRWSPAGTVHLVLQAGAIGQLLAEPEDTSFFAGGELAVGADVRLAQEAHLRALLVGAGQTYDDQRLTRADGEVVERSGTGFVTGGVRLIVGLVLVPFLALRVGAELGFEGIASVGRMTSYGGGLVEAALRLTDEERLELLLQVAVQSRARGRWVRTDPPSDAESEHFPAGRLMLGVGWVF
>NZ_CP011125.1|WP_053230990.1|863540_869864_+|OmpA-family-protein
MSERSLVVGSLASLLVVLSLPAPTASAQTRAATLRTRFDQPGDITFAANSIMTCRAGTGGSGANLCETARASASSTRDDNDYAMVPIDADNGVLPAAEASTTFDSSSSDLVIAPTATVSWAGLYWQCVSSGNSSTPAPDATRRNRVLFRAPGGSYTEVTATVLDAIVDNGANLFQGFADVTATVQSAGAGTYWTGNIQCDSGATNHYGGWTLVVVYRDETEPLRDLVVYDAWRTYNATQIDIDVTGFVTPPSGSVNSRVGVVFYDGDRGSTDTLRLISGTRNTLLGGGTVNPNDNIGNSTITRFGANVTTRTPAYVNTLGYDADLIATVDALPNGATSARIRGQTSGEFIALGVVTFATDIYAPEIDLAKTAVDVNGGQLVPGDVLEYTISGVNSGQDPAIGVVVRDAIPAGTTYVAGSLRVDGAAVTDSPGDDRGEYEVANARIVARVGTGANAAMGGRMNPSDTTTIVFRVRLAPAIPGGTRITNVATATYSGLTLGTGTTFTGSSDGDSGTPGNQPTETPVGAICGDTVITSPETCDDGATANGDGCSAFCRIEVRVVSPDGTTTSSTTPPISGTADPSATVVVAIDGAAVGTVTANAAGAWTFTPATPLAAGAHTIVATATDTGAHVTTDTATVTIDTGTTVAITTPAEGSATSDRTPAISGTGEPGATVVVRVDGNVVGTVTVSAGGTWTVTVGSNLAEGAHTVTASATDAVGHTATDSNTFRVDTATSVAITEPAEGATTSDTTPTIRGTAEPGATVVVSIDGTTIGTVVASAGGTFEVTPTTPLADGAHTATARATDAAGNVATDTSSFTVDSTTFVSITAPEEGDTIASATPTITGTAEPGASVEVTIDGTVLGSVTADASGAWSIVVPSALAQGPHTVVADALHGGATASASATFTVDSTTTVELQQPTEGEIVGTATPTITGTAEPGASIAITIDGAAVGTVTADAEGNWTFVPSTPLGEGTHDVDVVATDGIGNTATDDGSFVVDTSLPSLEIVSPGDETSTASTTPTITGTSEPGLVVTVSIDGALLGSVTTDASGAWSIPVTTPLAEGPHEVVATTTDAAGHAATDENQFTVDTGAPTVTITSPAHGARVPTDAPTITGTADPGATVEVFVDGALVATVTADASGAWSTTAGPLADGSHEVRAVARDDAGNTATATSGFVVDTSTEVAITSPADGGAVGSATPTITGTAEPGASVEVRADGTVIGTVVAGADGTWSIAITTPLAAGDHTIDAHATDSVGNTADATSDFEYDPSSLDTDGDGLSDADECPDAPCRDSDGDGDPDYDDADDDDDGVPTSVECTTAPCADTDGDGTSDHLDTDDDGDGVPTRDEAPGGVTRDTDLDERPDHLDPDDDGDGLPTSDECGTAPCRDSDGDGDADFVDPDDDDDGIPTSRERADGDTHGDDVDGDDRPNWLDTDADGDGRLDGDEGLGDEDGDGTPNYLDPFVPAPDAGANDGDAGTGGDAGVTGGGLAGGACHCSTPGAMGARGNVGLAIAGLLGLALLLRRRRGVIAAVGVGAALASTTTAHAQSQGFTLDPFRAAETPNDGFAVSGVRGLGHLDFGARLVLDYGLDPLVFEERLGDASTQTISVVEHQLVGNLALSLGLFDRVVVFAGLPATFVSEGQDSALGLTADGTTIGDPYLGVRVRLFGEANDVAALALQVAGSAPLSEVASEGQRFAGERGFVFLPRIALEVRPHERVRFAVNVGARLREPSRIVNLEVSHELTYGVGATVVALPGVLDLVAELYGSTGFETFFERESSPLEAIGGVRVHPVCGFNVGLAGGAGLTRGYGAAAFRGVLELSYAYEARCREQPAAAEPLAPPPPSDTDHDGLLDDADQCPNEPEDADSWQDEDGCPDLDNDADGVLDTSDGAPNEPEDRDGFQDEDGVPELDNDADGVPDASDGAPNEPEDRDGFQDADGVPEPDNDRDTLLDPEDECPTAPGRVEDRGCPRAVRLDEASGTIVILQRVEFATNRDTILERSFPILEEVRAVLDANPQLRRVRIEGHTDDRGRDDRNLDLSMRRAGSVMRWLVEHGIDATRLEGAGCGELHPMDSNRTQAGRQLNRRVEFLIVDPPSPTARAAREGCVSVTD
>NZ_CP011125.1|WP_053238668.1|862170_863394_+|ATP-grasp-domain-containing-protein
MDVVFLEPCFPANQREFVRALHAVGARVTGIGERPKEALDESLRHWLFHYEQVGNVTDVAQVEKAVRWIQQKVRVDRLEAVVEAHVMCAAQVREACGIPGTSVRTTFLCRDKPSMKEIARQHGIPTAQSLGTNDPDAVRAFAAKVGYPLIVKPRDGAGASGTMRVDSDAELESAIREYRLGRGGSAAVEEFIEGHEGFYDTITIGGRVVHEFVCHYYPNVLEAMRTRWISPQFVCTNRIDSAAAYEELRALGRKVISALDIETSATHMEWFFGPKGLKFSEIGCRPPGVRAWDLYAAANDFDIYREWAHAVVHGRPSQSLSRRFSAGIIALRPDRDGVISHYDGVEEIQRRYGEWVIDAHLPPPGTPTQPVEAGYMANAWVRMKHPDYDELRRMLDAVGQTVKVRAR
>NZ_CP011125.1|WP_053230989.1|860420_862118_+|hypothetical-protein
MIQLRRLVLLATLIAPAACAGPSAPPALVDDGGTMPTSDAGAPPVPTDDAQIVDPDAGAPIATRSLALRNAGWGRGALVVEGHPPCDAECTLAIPEGETVTITAQPGYGQRADAWGDECAAAEPGGTCTITMDVDRTASVEWTGGAAVAARVIGGAGVQQVVDVDVASDGDLVLAVEIEGATTLSDGETRVAYGPSDCLVVRVSSDASTVRWVARTRGGGREECEDLALGEDDDVFVVGMVTGAFSMGAEAFTAADFDAFAARIDASGEVLWATRMPSLAAGAEATLDLVVHDDGHVYASGYAATGAGMRAAYFVIDAADGTATTHSLGGTGSAYALAIELAPDGDLYLAGNFAYELGSPAVLNAPDDSDAFVLRMSTEGAIAWARKLSGSGQDEVLDVAVDDDGNVYAVGIFEGTITLPARPAATTSLGSIDWLVTSFDAAGAPRWSRSGGGPGVDVVNRIVWAQGDLYVAGQWEGTATNPATTATSSGHADAYVVRFASTGNGGRFVRYFQAEGDEWIGGLAVRGDRMIVVGHFDGTSQLGMPADATPFVSLNRDGLVYLGGS
>NZ_CP011125.1|WP_157068677.1|858885_860238_+|carboxypeptidase-regulatory-like-domain-containing-protein
MSRSSTFVTTCLLSSLVVVATPGCGAGPSSPMPDAGPLAQGDAAMPMPGDDAAAPEPTTLDVSGTLIDEAGAPVAGAHVHAGGRSAMTDAEGRFAIDALSAPYALRISFTGETRVFVFDALSSATPVLRLRRGWAVRDASLRGAIAMGATPLGDDESIRVGVTTHDRHFDGVAALTHDSQAVWELGATASASLLAVRVREDAEGWPVAYTWLATASREDVAEDATLTGVDLVGTPCGTAHVDLSMRFNEGAAQGYLYAYARVGDAFVRVTDGLEVDDGTRTVAVPTTAGASAAILALGHGANVRAVAMRTSVPLGAEVELTVPDLVLQAPEGAIGPGDRIAWTWSGGDAYFVVELLVSNGDLGYAPYLLMSTNEREVEVPDLADIGIAWPEGRATSIYVYAFAPVEGFEGDEATSFEWGAAINHALSDDLPAYDGALVRVESHTHTSGSD
>NZ_CP011125.1|WP_053230986.1|858093_858723_-|SRPBCC-family-protein
MRNAFGAEFRRLEDRDHLGQRAMVAVAIRTYDTTIEDLWEALTSPERLPRWFLPIEGDLKLGGRYQLVGNAGGTITRCDRPEALDVTWEFGGGVSWVNVRLAPDGKRTKLTLEHIAPRDGVGEEHLAKYGPGAVGIGWDLALYGLALHIDAGGAPVDRAAVDAWMASSEGKAFVRASGDAWGDAHAASGEDREAAREKAERTIAFYTGG
>NZ_CP011125.1|WP_075097437.1|855296_857891_+|phosphodiester-glycosidase-family-protein
MRALSIACVVAALFSAPARAQTISSRAWSDPQPGVRLLTGRTTSPTTRFWALHVDLCAERVHVAATSRPTSRRTAASWGASVGVQAAVNGDFFRTDTSTPIVYGQAAGSGAAWPVAQTGEAAAYRDDWYYRDYGWIAFGPSWVEFSHTGAVKRAGGATQGFMPGMVTGAIPAGTTALVSGFPELVTEGRRYTCSSPTASSCFPERSDMRARHPRTAMGLSDDRRTLILLVVDGRSSVSAGMYGTELASLMDQLGAWQAFNLDGGGSSQMWLEGRGTINAPSDGTPRAVANHWGIFAGTAGGRPVAPGSCIPRELDDCFRTSQDGGACGELEAVLGASDLGRTSDVDGDGRADVCARGVAGWACRVSTGDGFADAAFAIDALSDTAGFDQASRFSTIRTGDLNGDGRADVCARSSAGVRCWIAGDTGYGAAISGPALDDAGDWDRAMYFSTIRLADVDGDGRDDLCARGYSGLRCWRSAGDALEAESHEGPAWGNAAGFDQPSRYGTIRFGDVDGDRRADVCARTASGVECFLSDGTALTRRVEGPAWSDASGWGATKHWSTIRLADVDGDGRDDLCARGTSDLRCHLSTGEGFAASATIVAPLADESGWGDHDNYATLRVGDVTGDGADDLCARGNAGMRCYAREGDAFRTIDGPALADAQGWDDPRQYSTIRLADVTGDGLADVCARGADAYACWPSSGDGFGAAITLAAFRDAQGWGDARFYSTMRVAGPVCVARQEVCDGGDDDCDGVIDEDACERDGGTSDDAGSASDAGTSSDAAARGDASIAEPASSGCACGVAGRGTARGGWAIALLVLVAWIARQRERLRLPRAISVASASRRGSQNVRKRSSQASTSASGRASTA
>NZ_CP011125.1|WP_157068676.1|854305_855118_-|hypothetical-protein
MPDTREEEVRYDAEAAERGFRDTTALRAAVRDPSAPRGLDLQQAALFGLRIARQLAEPAVKARFDRLPDDLLSPSARNTIGPAAWALWYAVARRASATAGESSARLSEATLQRASAIKARMMKVAEYVLDGDARAATELASIRAGAGHADLAEDLTRLAALYREHAARLAEGGVHYRRTDARSARDAAAAILAELNDDEPSEARIAREDAFRAFRVLEQTYEPVRLFGRALFAHDGEERFPTIYSIRPARGSRTSEEGEGEEEGEQDEDK
>NZ_CP011125.1|WP_053230983.1|852499_854041_+|sodium:proton-antiporter
METFEIVVALVLAGAALTAVSRRIGAPYPATAALVGAVIAMLPGAPEIVLDPELALTLFVAPLLIDAAFDASPRDLRASWRAVSGLALGAVVLTVAVVAIVVRALVPSMPWPAAIALGAIVAPPDAAAATTVLRQLRPPHRILVVLEGESLFNDASALLIYRLAIGAALAGSLALESVIPMLLVVSAGSVVLGLVLARAVLWITARIDDVALAVVVQFGATFGVWMLAERLHLSGILVLVVFAMAYARRAGDVIPARVRVPSYAVWELAVFVLTVLAFTLVGLQLEAIVGRMSASLLLEHVAIATAVCVATIVARIVWVSGAALVQRRAGASALPPRAAALVGWCGMRGITTLAVALALPGGVHGEPAFPHRDLILFCAFAVVLGTLVVQGLTLGPLARALRLEDDGEVDRETALARAATLRAAIAATDAHRGAQLAELLRHRFEVMLSRVEHQRPSGEPHDAIVVQAAIDAERRHLLALRADGTIGDAAFQRVERELDLEELHLEPLASRSR
>NZ_CP011125.1|WP_083458455.1|872369_872990_+|RNA-polymerase-sigma-factor
MTAAVLGRTAHQVPASSEQALVDRLKRGDAAALGEAYDRHHEAVRAFARRLLGNEAAAEDLVHDVFVALPDLVRRFEGRSSLRTYIVSIACNHARHAKRATARRLGALERLHAEPRDSTPDLEAAEERRQLAETMRRLLDALPMEQRVAVVLCVVEERTSVEASEIMGVPEATVRTRLFHARRKMREMLESEARTEARAAGIEVRR
>NZ_CP011125.1|WP_053230995.1|872986_873703_+|hypothetical-protein
MNDDEFDAMLSRAGRAMREEVGGESDQAARTRAKILASRRASTQRTMFAMAAAAVLALGLGVPTVWAWSTGRLDAWLGEDEPAPSTTEVAPPPVREVAPREVIEVAEPEPEIVAPIEPMPEPVVVEQRERAPEIEDDEDDDDGRMRGVDPAERRAYREAHALHFDARDPAGALTAWERYLDAYPSGRFALEARYNRALCLVRLGRDGEARDALVPFAAGEHGTYRQREAAELVEALGE
>NZ_CP011125.1|WP_053230996.1|873699_874857_+|hypothetical-protein
MSAREIVMGAAIAMIAALGWCAAASAQEVGAIELVTRGLDARSVEVERVRRALAEELHTDVRVRAVARRRREGTTIIALRSTGRGEIAVEHERADGTRLTRAIVLPEDAEERVASVVIVIANLVRDEASELLAMLRARRVPAEPEATTETPPEPEAQTETEIVAETEIVADSESVAPAEAEAAQIEPAEPEVVAETTHVEPGVRIRSSSATTEAHATTTPVVATRSVSREPFMRIGLETLMGSVQRVDGYDFTMLGGLHVAFMPSEFLAFGLRDIGGGTVGANDRIHNELTPFVELAWRPMFELALYGQLGAEIQMQVLGGRGAAVGVAPMIVVGSRFHVAREFSIGIETALHGVVTDTLLTHFHGLPQGAVLWTAGLSLLFHIS
>NZ_CP011125.1|WP_157068678.1|874929_875904_+|hypothetical-protein
MSTPRPPRAIVLLGAQRFDPTLGAAAAELGLDGPIATITAGWQEREGEDSDLHEHLGKRTINLRLHRRADEAFRADPELHAAHRKKQERLRHKQDFYRIRLEHELDANHVIRQRKAPPEILAEEEAASIGAIRLLDEYHLGQCAKVESEFDAAWRPFERDSIARHRHEIAEILRDTVAIAIAGGHVATLLNRLRLFGIAELIDGQVVLAWAAGAMAISDRVVLFHDSPPQGPGASEVLDRGLALCSGVVPLPHPETRLRLDDAERVALMARRFAPARCLAMPAGARITYRDGRFGSPHRVLRLSIDGTRAPVQPTDDLLPEEWA
>NZ_CP011125.1|WP_157068679.1|875894_877049_+|enterochelin-esterase
MGMTQSQLLAIHELEASQPDRAKVDAWMAGRRFPIVEGGRVTFVFRGDADGVTLRHWVYGLESNSALQRIQNTDLWYLVLEVPPGSRVEYKLEIHRNGHSQWIEDPLNPHRARDPFGANSVLQGVGYEVPEWTRPDPLARPGVLEPFAFHSKALGAVRHGHVYLPARFRRTRLYPLMIVHDGSDYLNYASMKTVLDNLIHRLEIPDVIVVFTDSPDRLREYANDERHAKFLTEELVPDLQKRLPLQDRPQSRCLMGASFGGVASLSTAWRYPGFYGRLLLQSGSFAFTDIGRRNRRGPLFDRVVEFVNAFRAEPTAISERVFLSCGVYESLIYENRSLVPLLDGTGMQVKLVEARDGHNWENWRDRLREGLSWLYPGPLMMIYE
>NZ_CP011125.1|WP_075097808.1|877185_878427_+|hypothetical-protein
MTEITRNIGLSLGADICWPLCYEHLMKRLDLRIPTKDGDTIRFHVERVTIEPFDLRQPVKYDVVIDRLTHWYHTSREWIKKGVVMNDLYVFNNPWSVQSMEKHTSYAAMMHLGMPIPETWMVPPKSYEPTADLRPTLNRYAKLFDLSKIAEKLGYPHFMKPYDGGGWRGVTKIDDTTKLRQAYEESGKSVMHLQAGVNGFDRFVRCIGFGPQTKCVLYDPSAPLHDRYTMAKDFIPKAEEEHLAKVTKTINAFFGWEFNSCEALRKDGVWYPIDYANPCPDSQVTSLHYHFPWLVKAYIRWSVFCAATKRPMRRTLDWDPFYRIAAGELSYEEKLDHYAKVADQRFERDQFEEFCGKHLAHLDEVACEFFSTAEAYDAVRQKVSALFPAHEIEAFTELFWKRIQAWRADERGV
>NZ_CP011125.1|WP_053230999.1|878423_878726_+|hypothetical-protein
MSADEEKLRARFADAEDEELQLIARSASQSSLARAIAREALIARGLDAPPELDPSAPRVTSTTRAPREPASGPSTAALARALIAAVIAVIALAIRCGSGG
>NZ_CP011125.1|WP_157068680.1|878764_879532_+|hypothetical-protein
MSRAIVVGVLLLCATSSVRAQDGRVADRAAEADLEDVLGPGASGARARRIAPPVYDADLQAALDGAEPEVRRCIEETMPGVRASLRARVRVSARRGVTITQTLRPRSAQAEACIDLAIRRWVQPLLSRPLPTPLDGTLRIAIGGVIVPPPPPPPPPPPPPPPPPPSRYDEGQVHAALDAMRASLIECVPDLSPGIAGRITLRVSVRPDGSLTLMGVQLPTGVRGASSLSCLASRVTWLRVPPPPGERLVVHHVDL
>NZ_CP011125.1|WP_169791323.1|879532_880828_-|peptidoglycan-recognition-protein
MTASSEELLEGWAREGEWLVSPVLEVPDGVSRAGAVVGLTSPGEIPAMEARVLSAGDPTGHWTALGATWSEEDQHVAVADLGAIGDGAQLRIRADAVEIVQLLRWTATIPDVGAEIETPEDDLGVAREALRTELHGLGIVTRESWGARATRCTDGDARKTRFAVHHTVTSSTDPARQMRGIQHFHMDTRGWCDVGYHFLVGQDGRIYEGRPLQLLGAHVGGNNSGNIGISFIGCFHTSGCGGLGASRPSDASIQIAGRLVGTLSRLHGITVDSARVRGHRDHSGQSTTCPGDHLRERLSEIISVGRTQTLSGGTPTPTPTPTPTPGASCRHTFGGSYTNAACSASYQCCDGTWRTRGACGACTCVETSGETGCSAGPPAGASCTHSFGGRYANTACSSAYQCCDGTWRARSSGGCGTCLCTEASGSTGCGA
>NZ_CP011125.1|WP_053231002.1|881048_881957_+|sterol-desaturase-family-protein
MLYELAQRGNFFTTWLALTVIAFALTMLMSGALFRRYYWRPTFETWRYKTNPQFPKPVMIRREVLQMLKGIYTATLCPAIALHLVDAGWSQAYGGLGGYGVGYLVFTFFVVWIGSDLYEFAYHRLGHTRAFWWKQHKPHHAFANPTPFAVIADDHLDQLIRSAPLLFIPMLMPINMDLLFLTYGAFFYGYGVYLHWGYELRWPDAHHPWINTAFQHYIHHARSTLMQPMHTGFFFKLWDKLAGSEYRAGPETCACAKCSIARGERTREEFERIVKPDYSPLLSPSFWLTGKVRQVEEPAPAE

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Crispr_ID: NZ_CP011125_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_6

954102-954204

Orphan

Consensus_repeat	Method
GCGCCTGCGATGGCGAGCTCGAGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_6

>merge|NZ_CP011125|6|954102-954204|CRISPRCasFinder
GCGCCTGCGATGGCGAGCTCGAGTGTCAGAATGGTCGCTGCGTCGTCGCGCGCGCGGGGTGCGGCGGTTTCGCCGGCGCGCCGTGCGATGGCGAGCTCGAGTG

>NZ_CP011125|6|4|954102-954204|CRISPRCasFinder
GCGCCTGCGATGGCGAGCTCGAGTG	TCAGAATGGTCGCTGCGTCGTCGCGCGCGCGGGGTGCGGCGGTTTCGCCGGCG
CGCCGTGCGATGGCGAGCTCGAGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_157068689.1\|962794_963169_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791327.1\|945751_946447_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP011125.1\|WP_053231055.1\|954364_956419_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_157068686.1\|952371_953403_-\|AraC-family-transcriptional-regulator-ligand-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|378890
NZ_CP011125.1\|WP_169791326.1\|941952_943461_+\|RtcB-family-protein	unknown	unknown	gnl\|CDD\|376465
NZ_CP011125.1\|WP_053238672.1\|950329_950752_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381269
NZ_CP011125.1\|WP_053231049.1\|946511_948038_+\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NZ_CP011125.1\|WP_053231060.1\|960455_961823_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053231047.1\|945177_945726_-\|sterol-desaturase-family-protein	unknown	unknown	gnl\|CDD\|178053
NZ_CP011125.1\|WP_053231061.1\|961914_962742_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187627
NZ_CP011125.1\|WP_053231056.1\|956443_957340_-\|DUF882-domain-containing-protein	unknown	unknown	gnl\|CDD\|225650
NZ_CP011125.1\|WP_157068688.1\|957345_958908_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372323
NZ_CP011125.1\|WP_053231050.1\|948118_950329_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053231064.1\|963782_964202_+\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NZ_CP011125.1\|WP_053231058.1\|958904_959618_-\|ribonuclease-III	unknown	unknown	gnl\|CDD\|234633
NZ_CP011125.1\|WP_157068690.1\|963168_963786_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053231046.1\|943465_945109_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200478
NZ_CP011125.1\|WP_075097811.1\|950901_952164_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP011125.1\|WP_053231053.1\|953543_953960_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053231059.1\|959646_960447_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_169791326.1\|941952_943461_+\|RtcB-family-protein	gnl\|CDD\|376465	pfam01139, RtcB, tRNA-splicing ligase RtcB. This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyze the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage.	1.58793e-110
NZ_CP011125.1\|WP_053231055.1\|954364_956419_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.11693e-85
NZ_CP011125.1\|WP_157068686.1\|952371_953403_-\|AraC-family-transcriptional-regulator-ligand-binding-domain-containing-protein	gnl\|CDD\|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	2.14664e-41
NZ_CP011125.1\|WP_169791327.1\|945751_946447_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.92035e-08
NZ_CP011125.1\|WP_053238672.1\|950329_950752_-\|hypothetical-protein	gnl\|CDD\|381269	cd12131, HGbI-like, Hell's gate globin I (HGbI) from Methylacidophilum infernorum and related proteins. HGbI is a single-domain heme-containing protein isolated from Methylacidiphilum infernorum, an aerobic acidophilic and thermophilic methanotroph. M. infernorum grows optimally at pH 2.0 and 60C and its home is New Zealand's Hell's Gate geothermal park. The physiological role of HGbI has yet to be determined. It has an extremely strong resistance to auto-oxidation, and has fast oxygen-binding/slow release characteristics. Its CO on-rate is comparable to the O2 on-rate, and it is able to bind acetate with high affinity in the ferric state. The coordination of the heme iron changes in the ferrous form from pentacoordinate at low pH to predominantly hexacoordinate at high pH; in the ferric form, it is predominantly hexacoordinate at all pH.	1.62823e-46
NZ_CP011125.1\|WP_053231049.1\|946511_948038_+\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	1.558e-122
NZ_CP011125.1\|WP_053231047.1\|945177_945726_-\|sterol-desaturase-family-protein	gnl\|CDD\|178053	PLN02434, PLN02434, fatty acid hydroxylase.	2.97239e-19
NZ_CP011125.1\|WP_053231061.1\|961914_962742_+\|SDR-family-oxidoreductase	gnl\|CDD\|187627	cd05369, TER_DECR_SDR_a, Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR. TTER is a peroxisomal protein with a proposed role in fatty acid elongation. Fatty acid synthesis is known to occur in the both endoplasmic reticulum and mitochondria; peroxisomal TER has been proposed as an additional fatty acid elongation system, it reduces the double bond at C-2 as the last step of elongation. This system resembles the mitochondrial system in that acetyl-CoA is used as a carbon donor. TER may also function in phytol metabolism, reducting phytenoyl-CoA to phytanoyl-CoA in peroxisomes. DECR processes double bonds in fatty acids to increase their utility in fatty acid metabolism; it reduces 2,4-dienoyl-CoA to an enoyl-CoA. DECR is active in mitochondria and peroxisomes. This subgroup has the Gly-rich NAD-binding motif of the classical SDR family, but does not display strong identity to the canonical active site tetrad, and lacks the characteristic Tyr at the usual position. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	6.82575e-93
NZ_CP011125.1\|WP_053231056.1\|956443_957340_-\|DUF882-domain-containing-protein	gnl\|CDD\|225650	COG3108, COG3108, Uncharacterized protein conserved in bacteria [Function unknown].	1.09992e-13
NZ_CP011125.1\|WP_157068688.1\|957345_958908_-\|hypothetical-protein	gnl\|CDD\|372323	pfam12810, Gly_rich, Glycine rich protein. This family of proteins is greatly expanded in Trichomonas vaginalis. The proteins are composed of several glycine rich motifs interspersed through the sequence. Although many proteins have been annotated by similarity in the family these annotations given the biased composition of the sequences these are unlikely to be functionally relevant.	0.000461512
NZ_CP011125.1\|WP_053231050.1\|948118_950329_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.80637e-83
NZ_CP011125.1\|WP_053231064.1\|963782_964202_+\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	1.64495e-15
NZ_CP011125.1\|WP_053231058.1\|958904_959618_-\|ribonuclease-III	gnl\|CDD\|234633	PRK00102, rnc, ribonuclease III; Reviewed.	2.10619e-88
NZ_CP011125.1\|WP_053231046.1\|943465_945109_-\|hypothetical-protein	gnl\|CDD\|200478	cd11339, AmyAc_bac_CMD_like_2, Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins. Cyclomaltodextrinase (CDase; EC3.2.1.54), neopullulanase (NPase; EC 3.2.1.135), and maltogenic amylase (MA; EC 3.2.1.133) catalyze the hydrolysis of alpha-(1,4) glycosidic linkages on a number of substrates including cyclomaltodextrins (CDs), pullulan, and starch. These enzymes hydrolyze CDs and starch to maltose and pullulan to panose by cleavage of alpha-1,4 glycosidic bonds whereas alpha-amylases essentially lack activity on CDs and pullulan. They also catalyze transglycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules. Since these proteins are nearly indistinguishable from each other, they are referred to as cyclomaltodextrinases (CMDs). This group of CMDs is bacterial. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	4.30293e-83
NZ_CP011125.1\|WP_075097811.1\|950901_952164_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	7.65171e-75

>NZ_CP011125.1|WP_053231053.1|953543_953960_+|hypothetical-protein
MDLSVVFQRDGALDMRRGFDVGAGPSAGIDVILGALDDLARDGELDPEPLRTASWLAQWEEIVLGEGERRGWSREGVDPVVALCERAELARILSAMEALRPAVVETMSAHVSSWDALSSFLRACHAEGSIALWCDLAG
>NZ_CP011125.1|WP_157068686.1|952371_953403_-|AraC-family-transcriptional-regulator-ligand-binding-domain-containing-protein
MTKGGGGSVSVMGALMVLHCAEKSGADRARILERIGLTPDRLKDPEAHIPLPTHHQLWETAIEECGDRALPLRVAEDSDPSKFSVLGYTCMTAATVREALDRLARFLSLFLQGETLTLEQHAEETRLTLHQTAPRRLGRELSGESTMAKIVITVRVLIGHENGGRSWSPSLVSFTHAAPADTRPHEQLFGCAVRFGAPRTELVIPRAMLDLPLAKADPSLSAFFERHAEEMLRRMGARADATARVRRAVSEALHAGEVSETNVSRRLGWSERTLRRRLGEEGTTFRQVLDDVRRELAQGWLVQSEMAIGEVAFLLGFSESSNFHRAFKRWTGQTPDEFRRSQR
>NZ_CP011125.1|WP_075097811.1|950901_952164_-|sigma-54-dependent-Fis-family-transcriptional-regulator
MLGRGSAPASDGAPRARFVRQRPWGDGPSEPLASPRLSREQLRIEPTAKGLRVASIGRAPMWISGEPATEREIVPGDTVRIADELLLLAVRRPTRMDAQRAWGEDEAPFAFGAPDRFGLVGESVAAWTLRDRVAFAARADAHVLLLGASGTGKELVARAIHQLSSRASGPLVARNAATLPEGLVDAELFGNVRNYPNPGMAERPGLVGEADKGTLFLDEIGEMPSTAQAHLLRVLDRDGEYQRLGDARPRRASIRVVGATNRARDELKHDVRARFGIVLEIPQLDARPDDVPLLVRHLVSIAATKTRVPAPEPSIELVDALLRHRYELNVRELEQLLWQAMAESRAGKLELVPSLVDRLATPEREGEPAGEEKEPDREAIEAAIARAGGSVTKAARELGLRNRYVLYRLLRKHGIAVDGL
>NZ_CP011125.1|WP_053238672.1|950329_950752_-|hypothetical-protein
MSLDVPLLRSSFELVLEREPALTARFYEILFERYPQARPLFARNARKQQEEMLARALAAVVDRLEDAPWLVETLGAMGAKHVDYGVTEEMYGWVGDALLRTLAEVAGDAWTPELEAAWAAAYGAIRDLMLAGASRAQAAE
>NZ_CP011125.1|WP_053231050.1|948118_950329_+|alpha/beta-fold-hydrolase
MAHAVRDEGDWDPPREFDGFVVVGPLGRGGMGAVHRGHDVALDRPVALKFVRAAHPDPRERERFLREARALARLTHPNVVQVFRVGEVEGNPYIAYEFVEGSTLHAMRTPVRWDLALDLGIGMARGLASIHARGLLHRDIKPANVVVTSTGVPKLIDFGLALRIHESEAVDTSGPLPSGATGLTSIGRIVGTPQYMAPELFEGLPATLRSDVYALGLVLRELLTGERLRWGMPLDLLATRAIEDEVRVPRVPDAPQGLIDAVVRCLRRDPAERWPGADALRDALELLRRYYRPFAQPTEGRGVEDEYGRLTASFARIASSGDAMISRFYTLLFERAPDAKPLFPHDLEGQRHKLLHAIENVVAQIRAPERLVPLLEDLGRRHVAYGARREHFEQAESALIAALREHDPRWDAPTEMAWRTAISRLSEAMLRGMAIADTDLAETLPPAPSPGPTRRSTPVRAEVTQDLPRTSFVDRDGVAIAYQVMGEGPVDLVLVPGLVSHVERSWQHPASAAWQRGLSSIARLVMIDRRGCGLSERAPESYELDAQVDDVLAVLDAVSSRRAVIVGTCDAGAIAALAGAKARARVAGVVIVGGALRLGDALSSEVIDERAQAVRAGWGSAVLADLLAPSLAEDASFLAFWASLLRSSSSPGALAAQLRRGAEIDLTAHVASLDVPTLIVHRRGDRFVPQAQARALAEALPSAELVVLDGEDHLPLAGPRDALLDVIDAFVAKVTR
>NZ_CP011125.1|WP_053231049.1|946511_948038_+|Ppx/GppA-family-phosphatase
MNDVLPARTSPSSERETLAALDLGSNSFHLVIARVDAEGVHVLDERREMVRLAEGLDAHNTLRRPVERRALACLERFGASLRPLPRGAVRVVGTNALRKARNARDFVRRAEALLGHPIEIVSGAEEARLTYLGVASGDAPRPGERRLLIDIGGGSTECILGVGTEVASAHSLFMGCVSFTERYFPHGRIKRKHFESARNAALAELATFAEGWQGRFDQAWGSSGTMRAIDAILTTNKWGGAGITPEGVALFADAILEHRDVRELRIDGLAPERAPVIPGGLAIVSAALEALSIPRLRAARSAMREGILYDLIGRHADHDVREASIRSFAERHGVDREHAERVQATALALLRDVSVPWRLDLLDYGAPLRWAATLHEIGQSLTYAGYHKHGAYLVRNATLAGLAREDAIRVSALIGLHRRRPKLEYAAGLERAQQRDLLRVAVLLRLAAALHRSRAAIRPPVRAFASGKQLELRLPRAWAETHPLAMGEVRAEREHLRKMGVKLRVVAR
>NZ_CP011125.1|WP_169791327.1|945751_946447_-|TetR-family-transcriptional-regulator
MIHEPAKVRRREAKSERILDAAEGILEREGHDALTMQRLAAELELTVGAAYRYFASKDAIVAALQRRVFEGLAADLERAIAEYEAVHPRASRVGALSRVCVVARVYATLPERRPTHARLLSRMMGEPRNVLPEGLGDANAQVAMTLATRGVRELAAAREAAALGAGDDLERAILLWTSLTGLAQAKKLERWGVPGLDVDALTERLVVTLLVGWGAEPARAREALGRAAEIV
>NZ_CP011125.1|WP_053231047.1|945177_945726_-|sterol-desaturase-family-protein
MATWGIGLAVGVVAWTLLEYVLHRWVFHRRVLGRRAARGHLEHHAKVDFFYPVGGKLVMAAIVLTPIVIVCALALGWQLGSSIPVGIVVGWLIYEWIHRRIHVAAPIGAYGRWARRHHLHHHFQRADCNHGVSTPLWDVVFGTLAPREQVRVPRAHARKFPWLIEGDEPRIASAWASEYRIV
>NZ_CP011125.1|WP_053231046.1|943465_945109_-|hypothetical-protein
MMLALTACTSAPGAPPADGIDAGARRRDASIAIDGATERDVGPRVDGGDPFTTFDRAWWERAVIYFVMVDRFSNGDRTNDGDATCTDPSAPILFHGGDLQGIVDRLDYLEELGVTAVWITPVQRQVGRRGDQCGYHGYWADLGVPDDGAIEPRLGGEAALRALIDALHERGMRLIVDLVVNHAGYGARVVGQRPEWFHPGAGCETLGDPEIYCALSGLPDFAHERDDVADYLDAMSTSFVSRFAFDGIRMDTVKHVEESYFRERWVPAVREERPGLYLLGELFDEGGYALFDRYLDAGFDGLFDFPLRRALIDSVARGGSLGAVAGRAQEAVTRWGAERARLRATMIDNHDVPRFVEEMSSASDAEKSARLRLALGVLFTVPGIPQLYMGDELGMGGTYPLNRRDMPAWAWRAEDREGAHGGALPDAARIHDEVRALARLRASTPALHAGGYTELWRPAPGGVNAWAFFRSVGESRVVVAVNGGATTISDLQVPYRTNPGIADRDRETPDGTTLMRVHGPESATARVVEGRIALTIAPRSLAVFAMP
>NZ_CP011125.1|WP_169791326.1|941952_943461_+|RtcB-family-protein
MSRDSRELIRAGDWKRHCVWDAEGGYHRLETEDVGDVPVRLFLGDALLRECEQDVYRQIVNATRFPGVKCVVITPDVHVGYGVPVGCVILTDRDEGAVAMGPVGFDIGCGMVSARSDAPAEAATPDRQLEFNREVMERVALGAGGKSHRFGELSKRELEEVVRGGAEHYVEAHGARVDRHRAERQRIPVDDGWKIPWGGKGNPERGLAQLGTLGGGNHFIELQRSEQTSTLFVQVHTGSRGFGHGLATNYFEMARAEHPEQRDIDLGFFTPDSAHYREYLNAVAAGGNYAIVNRLVLFEAVAEAFRRVFRKDLELIYEISHNLVQAETHPEFGKVWVHRKGATRAFPGGHPALRGTEWEASGHPVLIPGSNRDWSYILRPKPGAVKSAYSVNHGAGRRLSRGEATRTLDQQKIDEQYRRDGILVNLDGRVPLDEAAPCYKSSDEVVSAVVAAGLAEIEHRLWPVCSLKGTEEGLRSPKARARKAEAKAREKARDQGRRMRGK
>NZ_CP011125.1|WP_053231055.1|954364_956419_-|serine/threonine-protein-kinase
MAVDDAVVQALVREGRHEEAARICAEGGQPARAAELLAAVWKHAEAIRVATDAGLYDEAYRHAVGAQDRELAASLLSSLAARPEQASRAASYAEARGRTSDAARLREAAGELEAAATLHERAGELGDAARCWKELGDVRKAGMLYERRLRDTPDDAESAFELGQILARFGRWDHAARALQIAADREELAIPAGKLLVACFDALGMTDAAQSRLDVLRALEPSMPATVPELLRASFGDERGPRSASRDQLIAGRYRVVRALGAGGTGRVLLAEDAFYGREVAIKVLHAGSSGAAGRDALSRFAREAKVAAGIDHPNVVQVYEYQPDGPFLVMEHMSGGTLEDRLSNGDVATALPASVVQHVGRSVLSALEAVHRRGVVHRDLKPANVFFGRTGEVKLGDFGVAHLADLGATLTGAMMGTLAYMSPEQITGSSRPDASTDLYSLGVIVYRALTGVLPFPGPDFVAQHLELTPARAITHAPWIGEALDTLIASMLEKDPAARPRTASEVLEAWAHLPWAHIEQEAQLAPRSATPVTTRRSSAPPAPPVERWSIVDVKLDGTTIADDELLRRRVVIVPCDADRARSLRALARADSPFLQAVWSIDEEGGRAILELPQGEPARAALDRMRAEEIRIALEGLHAQGLVHGHVDAAHVVVAEGRAVLMLPLGARVGSAAADLEALARLAQR
>NZ_CP011125.1|WP_053231056.1|956443_957340_-|DUF882-domain-containing-protein
MSRVSSRALAIASMVIAIVLALGSAAGLVPRADADDGVRACQHRGRSARRSRARSSRRRARRPRLTAAQRRQIQRWHQRASRSEVRAWARMDPPPLVFHPLRQRERVALVPASAEGGFDTDDLVLAQQALASREGAMHDIHPRLLELVYRAVRHFEVPYVHVISGYRDGRATSRHAQGRAIDFVLPGVSDRRLAAYLRPQGFVGVGIYPVSGFVHLDVRARSYFWSDGSGPSEPTRERAILAAQTSRYDAAARRRGEESIPDLDVGHDEEEVEEEESATPEIADEAAQPPPDAGVSAG
>NZ_CP011125.1|WP_157068688.1|957345_958908_-|hypothetical-protein
MRMCSRRALWSVCALVVVGCSLDRTGFGGGAGGLDASVRDAMIAIDARQSEIDASELDAGEMIDAGERLDASDLDAGELDAGEPDAGDLDAGEMIDTGVDAFRPCPIGLVECQGDVIAECNASGRFDVVETCPMGCLGATVPVRCAQLVPSHVADPTRLVAGTADLVVRAGEVVAIDTDTGRIVEIVSTAELRAAGAAGDASGMLLTTASQRAGTPDAAILSVGGVIVEAGGRLVASGPRALILLAAREVQIAGAIDVGGNGRSGGPGGGTGGDARGAGIGPGGGGGGAVTGTFGALMSGGGGGGHAANGGEGGDEGGISGTAQGGASGPALDDADVTVLIGGGGGGAGANADDGGDGGGGGGALQISSAVRIVIAAGGVIRAPGAGGREGDDGGGGGGAGGTIFLEAPRVVIDGAVVANGGGGGGGDSDPFGNGDDGERGRDDAARAGGGDGAGGGDGGRGGAGGDLAGENGGNGNGGGGGGGAAGRIRVLTRTGASSGAGVRSPSASGGYGEGVASSS
>NZ_CP011125.1|WP_053231058.1|958904_959618_-|ribonuclease-III
MVDPRDSASTVAQRLGHAFGDLGLLMTALTHRSYVHEHPELAAADNERFEFLGDAIVGAAAAMVLERRFPTAREGELTRRRADLVNEGALATIAAELGIGDALRLGRGEERSGGRQKPRLLASALEACVAAIFLDAGIEPAIAIARALLAPRIDALAPGAKDFKSRLQERMQARGETPRYELERTEGPEHERVFHVIVTAPDARVLARGSGRTKLEAEQAAARAALSELERARETDG
>NZ_CP011125.1|WP_053231059.1|959646_960447_+|hypothetical-protein
MDVESRRRSGGAVLAAIAASLVVIVAVSVPARAQLEVGVYEGVPWPIIAPPLGLPIPAPPRPTPAEPATPAAARVIEVLRGVQTSMRQTRYQHATVVREREGVFLWDCSGMAAWVLRRAAPRAMSAITRERPVARDFVSAIERAPARGGRSGWQRIEHIDAVRPGDVFAWRRPRGFPSRNTGHVGFVMEAPVPLPSIPGAYAVRIADSTSWGHQEDTRRDDGVGGFGFGTLVFLTDGQGHATHYGWVGTLSDGYVITPIVFGRPLR
>NZ_CP011125.1|WP_053231060.1|960455_961823_-|hypothetical-protein
MTTSATSELRTGVSLVQTHPGISVALGAAIVLSLCATCTGLGAIVGPWFVCELYGVQIAAATGIARPRTSAWIRAAAIVLATVVIVALTGWLAALGFGPDVATADAAEEPLPWPEALRRVGLITGSVILAVGFIAPFLYAPLVLIDRGGRIGGAVVESAWLASRGGALRHLALTFVVFFLQLSPALIAAMIVARTFERAATPLGLLGALPLMTITIPLGQAWTTAAYLERRALLAAPRAVQVRGPVPRSLVALLALDVLAPVLALAMLGLTALRPSTPAESDAPPGTTLIERDVQDERARIVVPDTTITVVVEGRELIVRAGDGDADGAGRLPRAWPSAIEQVRVVRARDVYAIVIEAGDRVFHTRVDGAGMRVDDSIRRRLEQHVPTWALLTILAAFLVFGLLGGRALASLGALRAEVDAPERAAAYARSMRWGLTIAPFVIAALLAGLVSITR
>NZ_CP011125.1|WP_053231061.1|961914_962742_+|SDR-family-oxidoreductase
MQHIFRAGLFDGEVAIVTGGGTGIGFAVARELGTLGAKIAICGRRPEPLAEAADRLRADGIDVHHAACDIRKTEEVEAFVDGVVARFGRASILINNAGGQFPTPAEHLAPKGFEAVVRNNLLGTWSMTHAVARRAFIPSKRGRIVNVIANVARGFPGMAHTGAARAGVENLTKTLAVEWAVHGIRVNAVAPGVIKTSGTAQYPPELLEMSRASTPLKRLGSAEETSHLIVYLASTQADFVTGQTFYIDGGASLWGSPWQIPDDEVPQYPPYPLPE
>NZ_CP011125.1|WP_157068689.1|962794_963169_+|hypothetical-protein
MSDDPTNSAAPEPEPEDTTGAKATKLSKKKRRRGAPSETTVPTRLPGEGTVEGEKLREANAAFEAGNYALVRTLTSELERASDPTIVDAARDLARRTAVDPLQMTFLVLCAVALLVITYVYVLR
>NZ_CP011125.1|WP_157068690.1|963168_963786_+|hypothetical-protein
MNRPLVTTFVVLALAGCGGAQPRTTTRTGPLRARELYPMGEGYIWTHDVDTQTGISTLGITRVTEATPPRFVIQADGARERHVYELREEGIWDVDANAWHVRDPLVVGETWDAGNGRTARITQTSQEVTVPAGTFSECVEVVVENTQTQGRSRTVYCPEQGPVIVEYHQELMTTGGITIHGELRAPLQRGMEDVEEPEGYEGPGE
>NZ_CP011125.1|WP_053231064.1|963782_964202_+|HIT-family-protein
MTVLDPRIEADSAPVGRLPLCHVRWMRDARYPWALLVPERPGVREIHELDERDRHVLIDESALVASALSRIVSAHKMNVAAIGNVVAQLHVHVVARFPTDDAWPRPVWGVHPALPYDPETLEARVASLRNALAPRLVDL

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Crispr_ID: NZ_CP011125_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_7

1768274-1768371

Orphan

Consensus_repeat	Method
CACGCCGCCGCCTCCTCCGCGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_7

>merge|NZ_CP011125|7|1768274-1768371|CRISPRCasFinder
CACGCCGCCGCCTCCTCCGCGCATCGCGATCACGCCGCCGCCTCCTCCGCGCACGCCCGAGCCGCGCGTCGCGATCACGCCGCCGCCTCCTCCGCGCA

>NZ_CP011125|7|5|1768274-1768371|CRISPRCasFinder
CACGCCGCCGCCTCCTCCGCGCA	TCGCGATCACGCCGCCGCCTCCTCCGCGCACGCCCGAGCCGCGCGTCGCGAT
CACGCCGCCGCCTCCTCCGCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053231724.1\|1770891_1772880_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_157068817.1\|1762044_1762530_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157068818.1\|1762618_1763620_+\|PD40-domain-containing-protein	unknown	unknown	gnl\|CDD\|369459
NZ_CP011125.1\|WP_053231719.1\|1766962_1767535_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157068816.1\|1761341_1762010_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_CP011125.1\|WP_053231722.1\|1769082_1769481_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP011125.1\|WP_169791368.1\|1753706_1759448_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274730
NZ_CP011125.1\|WP_053231729.1\|1779653_1781273_-\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|133025
NZ_CP011125.1\|WP_053231725.1\|1773187_1774942_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053231720.1\|1767531_1768050_+\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|119400
NZ_CP011125.1\|WP_053231712.1\|1759655_1761341_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053231728.1\|1778470_1779628_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173848
NZ_CP011125.1\|WP_053231730.1\|1781269_1783396_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl\|CDD\|224446
NZ_CP011125.1\|WP_053231716.1\|1763670_1763889_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_083457215.1\|1765517_1766897_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|273584
NZ_CP011125.1\|WP_157070407.1\|1777625_1778456_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187664
NZ_CP011125.1\|WP_157068819.1\|1775194_1776055_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053231710.1\|1748529_1753557_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053231723.1\|1769499_1770792_-\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|237512
NZ_CP011125.1\|WP_053231727.1\|1776058_1777603_-\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053231724.1\|1770891_1772880_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.34139e-78
NZ_CP011125.1\|WP_157068818.1\|1762618_1763620_+\|PD40-domain-containing-protein	gnl\|CDD\|369459	pfam07676, PD40, WD40-like Beta Propeller Repeat. This family appears to be related to the pfam00400 repeat This This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].	0.000701301
NZ_CP011125.1\|WP_053231727.1\|1776058_1777603_-\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	1.27212e-99
NZ_CP011125.1\|WP_157068816.1\|1761341_1762010_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	3.0105e-21
NZ_CP011125.1\|WP_053231722.1\|1769082_1769481_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.38005e-28
NZ_CP011125.1\|WP_169791368.1\|1753706_1759448_+\|hypothetical-protein	gnl\|CDD\|274730	TIGR03696, tRNA_nuclease_WapA, RHS repeat-associated core domain. This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.	1.84404e-10
NZ_CP011125.1\|WP_053231729.1\|1779653_1781273_-\|NTP-transferase-domain-containing-protein	gnl\|CDD\|133025	cd04182, GT_2_like_f, GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.03377e-44
NZ_CP011125.1\|WP_053231725.1\|1773187_1774942_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.28676e-96
NZ_CP011125.1\|WP_053231720.1\|1767531_1768050_+\|gamma-glutamylcyclotransferase	gnl\|CDD\|119400	cd06661, GGCT_like, GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).	9.30574e-14
NZ_CP011125.1\|WP_053231728.1\|1778470_1779628_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173848	cd01159, NcnH, Naphthocyclinone hydroxylase. Naphthocyclinone is an aromatic polyketide and an antibiotic, which is active against Gram-positive bacteria. Polyketides are secondary metabolites, which have important biological functions such as antitumor, immunosupressive or antibiotic activities. NcnH is a hydroxylase involved in the biosynthesis of naphthocyclinone and possibly other polyketides.	1.85674e-91
NZ_CP011125.1\|WP_053231730.1\|1781269_1783396_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	0
NZ_CP011125.1\|WP_083457215.1\|1765517_1766897_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|273584	TIGR01372, sarcosine_oxidase_alpha_subunit, sarcosine oxidase, alpha subunit family, heterotetrameric form. This model describes the alpha subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Mesorhizobium loti and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members are share the same function. The model is designated as subfamily rather than equivalog for this reason.Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines].	1.88737e-43
NZ_CP011125.1\|WP_157070407.1\|1777625_1778456_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187664	cd09763, DHRS1-like_SDR_c, human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs. This subgroup includes human DHRS1 and related proteins. These are members of the classical SDR family, with a canonical Gly-rich NAD-binding motif and the typical YXXXK active site motif. However, the rest of the catalytic tetrad is not strongly conserved. DHRS1 mRNA has been detected in many tissues, liver, heart, skeletal muscle, kidney and pancreas; a longer transcript is predominantly expressed in the liver , a shorter one in the heart. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.45378e-101
NZ_CP011125.1\|WP_053231723.1\|1769499_1770792_-\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|237512	PRK13800, PRK13800, fumarate reductase/succinate dehydrogenase flavoprotein subunit.	9.07018e-07

>NZ_CP011125.1|WP_053231720.1|1767531_1768050_+|gamma-glutamylcyclotransferase
MSVAYFAFGANTCRDVLVRRRRIDPISSEPASLRDHRLAFVQRGIPLIEPAFASVLPQPGATVHGVLHVLRDDDMERLDRLEAAGYARVEREVHAREGVMPAFLYVTRSPTHGLRPSRRYRDLIVRGAREHGLPASWIDELERFPTAHVPGVSDAVPWIIEALDRVLRRAPD
>NZ_CP011125.1|WP_053231719.1|1766962_1767535_+|hypothetical-protein
MRSRTAFLVSLTALSLACETSRDAEPAPAPERTAPSAPGTPAGLVAASALASALPQRLGAFEATGTPEPHVELGVTPTTRVSAQYADGERRATVRVVDAQRAPDLVAGFAAAQRIPMPSDPSAPDELVPTGIAGRPALASWTPGTSTSEAQVVIAERFVVALTITPASVPEEAVDVLETFPFASFDALAR
>NZ_CP011125.1|WP_083457215.1|1765517_1766897_-|(2Fe-2S)-binding-protein
MAPRRFGPSDRERVTLRVDGDDVPALRGEPIAIALAAAGRVVLGRSVKYHRPRGASCYAGRCDGCLMRVDGAPSRMTCRVPCEHGMVVETQNVLGTAEVDLLAATDWFFPGGMNHHEMFTWSKPVNRVMQSVARRIAGVGKLPDEARAPIEPMRRECDVLVIGAGPSGLAAAAACARAGLRVIVADEETRAGGHLAHTPGVVRTAEDEAPIDARVVAERLAARAVERGAELALGCSVIAIDDEDPSMLVALADAPDALVRIEARRVIVAQGRHEGAWAFEGNDLPGVIGSDAACRLLAHGVLPGERVVIAGPTSASAPGSARLRALAAALESAGASVIGNFEISAIERAHGRAGIDRVDVRTVGGIESLECDALVVAPPSSAVYELASQAGADVVWREGGFEVVASHADGATRTPRVRVVGRASGVPSVPAGIAQGVAAARAIAQELASEMAGRHGGAR
>NZ_CP011125.1|WP_053231716.1|1763670_1763889_+|hypothetical-protein
MPRQRASELREYHESPPALVRDMEQWLDVGDRREAAQRVREWVVESYELARTTPARRKPKSRKPPRAAAKSR
>NZ_CP011125.1|WP_157068818.1|1762618_1763620_+|PD40-domain-containing-protein
MQFARRSIGALTLVLVALATPACGRVGYQTSSDAASPAIDAAPPDATTSDASWIGIDAGPPVPEACRFGTPEWVGAVATSGQEHGPTITANRRVLCFASNRPGGVGRNDVYCIERAAASAPWGTVTAYPVVNSSADDVDPALTPDGWEMIYASDRAGGAGGLDLYHAEFDSRAYTFLPPTRIDALSTPDHEGGAEVAADGVTIYFTRRPIGGGPTRLYVTRRTGTGLTFDEPTEMAELASEHHDTEPTISADGRTLVWCSDRPVLGRASLSYNLWCAQHDGSAWGPPIFVDGAALDAGDPCSPEFASDGSLFFTSGVLPGASGLDVFRAPPAR
>NZ_CP011125.1|WP_157068817.1|1762044_1762530_-|hypothetical-protein
MAGWRRASLTGLAMSIAAACGGAQSPDIQQVGAPQVHEGRVVAARGPVVPQRGDACVVEVLRTDDAYYNCRIRVECSGDTVYGLADGGYNACYRQGEDLVFARDRNGTRVDGDPRLYFDLAGGRVFVSDDAPDVELEIDLSGLPHDYEGPTTPPPDAMPGA
>NZ_CP011125.1|WP_157068816.1|1761341_1762010_-|OmpA-family-protein
MGRRTAVIAMLVLAACGGARDAARNAAVASSDRDVDIVDVDARVAGDPCPGEAEDVDGFEDDDGCSDLDDDRDRIADADDRCPREPETYNGLDDEDGCPDHCALPLTSGPIAPQRERFFFVKDSARLGDGALDLARAVAGTLSGNPQIKRVELHGHAGREERRPVALARRRAERLRDVLVSLGIDPARVVVIAHGASEPVTAGDTPEQRALNRRVELVLPDS
>NZ_CP011125.1|WP_053231712.1|1759655_1761341_+|hypothetical-protein
MPTVGDLLRYVLPVGTVPGSASTSLASCPVWPPDAFAAAATLVERSACYTRDRYSGRGLPRGSGARWSPYFGLEYLARTDAAGARWRSEMRVPDEAQKAWETIVAGETDPIGPETSDAVADAAIELLAIADEACEGIGFAPEHPSPITSFVLEEHLRFVSRTAAASVGAIPDVRVSLCIAVPHDRACVQPKSRAAQVGCAMRALSHHVALLPAKHEIETRWMVGDLDRAQGPFNLLCVPFPYRMRGDAIEAGPLVQGASGAGHFRVKQTWLPEKDKDRVAFVADLVRELVRVSEREVGQVHGVVLPELALDSPTVRGVAKELAKLPSLELFIAGTSAIYPKSGAPRNLVFASLLEGGEVRTHWWQSKHHRWRLDEGQIRRYHLGHTLDPARRWWEDIDVDDRQLSLYVFRPDASIAVLVCEDLARIDPVQPVLRAMGPSLVIAVLMDGPQLDRRWPGRYAGALADDPGSSVLTLTSLGMMERSVMPGETEPRQVALWKDASGQARELSLPRGAHGLVLSLDASREERWTLDGRTDRGRTVRLSLGAVRAVAHPSPPAWLSA
>NZ_CP011125.1|WP_169791368.1|1753706_1759448_+|hypothetical-protein
MKRAIRRIAVGLVLALGLPQTTAAQVRRDAMVQAPEVRRPGRGSVAGAYAAVGFDPETLSRGTIDVAGPFEAPDERGAPLVPIFPTYAPDRGLSEWGVGWSASFAIRRHRDRGDLDFATDDFASPWGVLVQGDDGAYYPRGMAARVRVTREPDRWSAVLEDGTRITFRDADAIRTSRGIYQWSVSEAVTPLGDRTTWEYAARSDQAKRPYVQRVTYGGRESTPQVEVRFDYDGTIGARHVDYASGVGVALDRRVREVRVSTWDPASASYLLRHRYELGYEESPAGVAFYLSRAQRFFASGEPDSPRTFTYRFGEQDAAEATLAEASVLDSYLEAWGVTALMPDVSSYVDVDRDGRTDLENRYDHELARHTDAGLEYETLPRDGTEDPECRPVPSLDNQPRLLARIDGEQRVLRTTAVGDVTRVTMCDRQGHRLSRVSVSGAGWTLGARTRLVDVDRDRRPDLVRVTSSGYEVMRNTGDASALSFAAVTRGTLTIPSPVDTLWVQDVNGDGIADLVGRTASALQVWPGLGGRRFAASGTRLQVRRASGEVISDLRPYQIAFLDANRDGLIDVLLSSGSTLRLYTHRGDRFSEQSVPALATVAFDVGYPVAVDLEGRGEEQALVSRRVDGANHAYAVTLTSPRAGLMVRADDGRGGAIELDYVRAPAIPGMTVRPPLLARVTTHDAGADSVTSHYDYDDPVFHSVSEGLVGYRLVRRASATSLGEIEFHHDDDVSGLVVATRTLDTLTADLPAGLHRFTEHVYEDALVRAVRTMREVRVRGGLRDAEGHEALGAVRDVIAWSEDGLCPEHVRTTGEHGTLEIVHTRAEVAALAGALHCEIATETEIGTHPARAALDFRYDARLVRNGVGQIERVEMLSGGEAHVLQQSTYDALHRLVSLTTPGRGTTTVAYAPGTGEMLEVVGADGVRGRVEERDARSGAMTRIAFDRGPGGELREHWRYDGMERLASRWDSVGAGSEAMPEEAISYAWASSTHPGSIVTRTLVDASAGTYAESAELFTAAGRAIAGLSRLESGWAVGDVTIETREQARTDVYRRAPIAVTGAGEIAFATLFDEASRDWVATTTSSVLGHTPGEEQLVRDGVTRRLATAVGLANGHLVHATYENGALFSTRELDAEGRVIAVTDGGGARAEIAYDALGRVVGVLLPDGTTRQTARFDAQGRPSEVAHDGVGSVRLVYQGAGDLVAERSWHAPDGTRVRSARYAYDAAGREIERTNVRASDGAEETFRFLYDGERPDGGVIPGQRGRRTSVIGPTFARWDRFLPDGSIAKSELVIDGGWRTIRLDYTHFEDGAIRSVDRLITDAAGAVLSSMRRTTQRDALGRIERVVLSSPDGTNARTLYALSYDDQGRLSHATIGSGDLFVPEYDPPTRTRVGYTHDTSDVTLTSREERDARGLVTTQHVELESASSSTSYDRALSYDARRFLRGSTGGGTTTAYAFDATGAMASAQDVSGARAFVRSGDVLQAGGVTYRLDGMGRVIARDDLAITYGPNGDVERAERGDRVWTYAYDETGQRLLKRENGVITMATLPGGVFLVGSDVVEPVIAGGHTVGLLVNGALRPLATDTRGTVIADGDGHAIDVSPFGVRSSHDALAAVIEYASSGYDADLQTVRMGVRDYDPYLGRFRTPDPLYMEEIDRCASSPTQCQLFAYVSNDPLSYVDPSGLEERPAGAQPINTTSYIESYEESTRAMVDGVVDGYNGNRPLIEASRHYFLFESWDWDTSTYMRPLYSTDRTYLTMLTRFALAPVGNPALREAELSFDRTARLLYTVDSAGPWQDNSTAHTANASTQTQDSVGTTRSNTTTHANEGSVGAAVGAPGGPSASFGAKSSVSSSDTSTHQTSRMVQTGSGNTTASTFPTQMRVSEVRLWMEIVDNHGNRNYYQLGRATLIDSRVRR
>NZ_CP011125.1|WP_053231710.1|1748529_1753557_+|hypothetical-protein
MPTTRFARTCDPDPRFAGVPRARRSRFALVALALVASACSTSIEPGVVPAASLSGDGGVDDGGAASFLLGDEFDDPEVAACDDSSLGGACSGSREYQRHRVCTTPPNAACNGGYCEAARSCSNWAFGHYVTSRTKRFTQSERCEWECIQENPNGGCYRRRRICWWEPSCSSSYETNLARSEASSRGAPAQAVSAITATAQSISVSTTQRRCDVTISNVPYPNTRADVNVCGCATCRHATCGTEEPYLYQPPGGAAPAPGSSTTPSCVTAEDRTTVATRWARLRDSWSRRALLSTADRARVAARVRTMLELHADEIVAIERADAIAAYAPEESAQPLSCEPGAQPITFGAACSTASRAFLGARLAMCERVAQDADGYAPRARGAVAWVLAPECLATLEHLAANPSCSTPEIEARARVAAFRMIERGLDAITERPSALATVDVTAPSGVTGTYRTLPELARQLHGIGRWYELARASEARAADEDAPAWTASHLDRLVGAMWRRARAARRVVGALCPALAPSSDLDGDCVPDGQTAPDVTTDLAAALTTTTERADRLDRNVLLAAFQETSIPAITGPSGTILPELAVTGHALRGEALLAITADALRGSLDRVDSLSPYNQLACRLTACGGARASGVDWSEEPRWAQTWALLGSVDDAAELQALVTEVGPDLADASTSTQPESWQSVWERIARRRVALAEDVAAASQQSAVPASERVDLAHVPTEQLTPGARALASVITRGNARAGSYAATGLVDPTRTDRRLRTIVSADGRAAIIESAGALVSQLEAAIVDYEQDRRAVVSDLLAMLGGARALDEVIEHREELVRELERTNADHAALRMTLQEYERRYAETYDPENGVDLMGDLDATLDDGAFVQEGGTRHYEVRGFHGARAFPLRRGMNIVDSIARGIEIDPANGGEPDPDRIATLSVTGPRMIAVHAAGEYSPLCALRSFQVAIPSHDGDDGVIVPPVAPGTTIGPEGFTIDVSGSSAEVRRIGESTQEDLGLLGPACQIASVAAGGGISAGTNERNRGQAAGTLCSAAAGIVSWLTGEYVSPVATTTSAETSTSARFSAGLRLRDTPFPMLPAGALVVIEMAPGSTMASDIRDIHLLRSGASSFFVPDAADLYFVVNDGWTSSCGTLAPPGDSNVVSLELRVLQSETGVAQQVVDAMAGVLESIRGDRALIVEQGSVLSTQLSAYREAAIHELEVSAGVSLADVPDSVRNAFDAYVSYELARLELATEIRARDRRVQELQAQLQALDDDLLHAGEQGRITALLPVGRLRNLDEYTDGTDEAHLRWLADSLTALAVEDLVPLIELWHPDLLPALVSPTTGDPAVRAALGRLASPPPTASPFSLVDDVALVVRAILSTYAATPMTHVGADRYVVGISFGRPGYAFPPEGFPPDPDADPAETPRSVFPRASSSDAARVWGAVFAATALAPSDVRCTSDAICEGAFDEGVTCDTSAGRCRGPVACVDLDGDGQAAECSAPGMQCVAEACVRGETRARVALQASDLYRALGGAGGHVACQSAAPIVQRSALVFALGRNFDPADAEILADMSTGRRVVARIDAQQPFALRDAETRYTLLAAPFLERTMPLVYTTYERVIPAFTAHTPAEQGHRGSSVLAPITVDFSALSTLRAARGGDGVSGTFESSELLLVMEIDAVPSTRPTWITTCAP
>NZ_CP011125.1|WP_053231722.1|1769082_1769481_-|universal-stress-protein
MYKHILAATDFSDLGDRALQKASELAIRLDAKLTFVHVMVSEESASPMYAQHEVRAHVKRLGERLPQHKDVQVELEVRVGDAPTEILAAAEAHDADLIVIATRGERGFAEWLLGSTAERVVRNARRDVLIVT
>NZ_CP011125.1|WP_053231723.1|1769499_1770792_-|HEAT-repeat-domain-containing-protein
MSAIVVAVWLGACAGPARSATSTALERGSLVEALDEYDRMRQLDGPDRELLGRIAALLLEQEAGGADRELRRQAIQELAGSGTAGEPVLQRIAHGDGASRVIALEALARRGDDRAALELRSFADDEDADARAASVLGMDPEEDRDALLEAIRWPNARARENAASKLAALVPDGEARAALEETSRVDPEPAVRGAAVRALGGYGPPALVALRERLSDPVPSVRMAAVDALIRADRDQAWAALGSLFETPPSSQGIEAARLMLVRARQGDEDRGARAYLLSALRAGEPSLRAQAGVALVSLEPSDDLRRVLSEALGREDDPGAKLSIARALLQQEGAEDEARGALRGLMQSGLEMSALQAAGVLAERGDDEAKAILAAFLRRPDPMLRRAAARALARDAMRPDDARSAMRDHDAQVRIGAAGAILAASNEDA
>NZ_CP011125.1|WP_053231724.1|1770891_1772880_-|protein-kinase
MRARTLGPYRIERRLATGGMAEVFVAQRLGPHGFQKRVALKCILPQHARDPDFVAMFIDEARLAAQLEHPSIVQVFDFGEADGALFLAMEFVDGTNVNRLLRAVAANREVVPISAALHIAAEAARALAYAHHLCDESGKPLTIVHRDVSPANLLLTKRGHVKVADFGIARCAQSDHRTDDGHVRGKLGYMSPEQVSGLDIDGRSDVFTLGTVLAEMLIGEPLFGSGTDLDVLLRIRNADLGVLDRKGRAVPQDVRAVLCAALARHPDDRPEAGALAEALEDLMRRRGSAGRGARELARLLHRLDLVAKTPQDEAAHEPGARPTAYVDPNGGARTGATVETPLATRDMLGKLVLETPSAWEVRLADGHTLGPLTFPELVRRIVSGEVDDRALVKRDAGQLVPSGEVPELQRYLGSSALRWNPAEIRDADRRGLVMPGAVLSLVHRITSDRETGVLHLWDGQRRKKVYFVDGKPDFVASTVKKEMLGEYLVQRGVCLRMEVDMALALLPRYGGRLGDALVGLGVLRPVELYRAISGQVRERYLEIFRWRNGQWAFRAGVRSEEETFPLEQGAHELLRDAALAADTSEIEAALSDVRERVLSRESRPPAPPSAYGLPEPWLRLLDVRGDMTLGSIVARETASGGDVEDVYRAFYLGLSCRLVKAA
>NZ_CP011125.1|WP_053231725.1|1773187_1774942_+|serine/threonine-protein-kinase
MGTTRTSANRSAKDSYLGKVVAGRYRLEALLGEGGMGVVYRARHVLIDRVVALKLIRPDLRSETHLRAWMLREARAANRVDHAHIVEIHDVGETEESELYLVMEYLVGSALSSEIAKGPMQLARAVDILEQMCAALARAHDLGVVHRDLKSDNIMLTTRGGRRDFVKILDFGLAALARDPRLAPKGAVFGTPEYMSPEQARGDDAAPVSDLYALGILFFEMTTGQLPFRSNDRDTLLEMQRTAPPPRPRTLAKDLPEAAEAIILKLLEKDPRRRFRDGHHLQEELKALQRTLPNTWEVQQQEGQAAAPAQPPPPPPAPSPGVVEWSRRAAYFSRMVARAYPNGRVPDDLQTAVDQLWEVSARASKLEGELASHQRKLDAIERRGRALRAEIGRKVEELAEEESRTLRDAAAERERLSRVKTKLDEARRAWERANAQALELERAAGDLRTWRGVFEEATANRARAEVLSEVLQDHERRALHKEKSAGDLRRQIDELRAQLARYGDALENDLAAGRDRIATRVREALAYEKTFTDCSALLMSHLKGRPEVGELMEEMRREEAQYASQSQYSPRPDQTGAHKALVGG
>NZ_CP011125.1|WP_157068819.1|1775194_1776055_+|hypothetical-protein
MGRAVVLSLVLVLAACGDDDARVDVDAGQLDAGGALDAGARDSGIDGGAIDAGEADAGSTDAGELDAGDVDAGEPDADTSDAGGDAGARLCAAGGGACDVALQDCPSDHACYYAEVSGVAATRCELVFVPGTDGDPCEFADECAPGLTCRAGTCRQYCCPGAALDCPSGQACVQLAEAPNIGHCAPADACTLAPNAGCAAGRACYPGPAPETVGCFVAGTTPEGGACVANNACAPGTICLGAGPFSCLRVCRTAMGDADCTNPAHDCIAVPGYLSAQYGVCDVPSE
>NZ_CP011125.1|WP_053231727.1|1776058_1777603_-|Ppx/GppA-family-phosphatase
MPKFASIDVGSNASRLLIVQADAPGRFTTVLQSRMPVRLGHSVFVTGKLDPESVDELVRAMRTFKTTMESESVEAYRAVVTASARDAENAEDMLHRVAETGVELEAIDGTEEARLVKLAVEQRVPLGDKRALLCDLGGGSLELSEVNHDEVRFSTSLQIGTVRLLESFLDDGKPVTKAQERLLGEYLDRMLQPVRESFLKRSYDVVAGTGGNFETIAELCPMAGAPLPTIDVRKARALLAKISKMKATDRRKEYGLRPDRADVIVPALYVLVTIADLARTDTIVAPGVGLKEGIVAELVHKHFRVWDYKVDESQAARAAVQLGRRYHFDEPHATQVDRLATQLFDRLRALHKLDDHDRVLLRVAALVHDIGDFVHFAAHHKHTQYIVEHSDVMGLSPEHRVVVGCIARYHRRAPPSPKHAAFASLGPEDRRRVRKLSSILRLADALDRGHRSKVHQLDVEVGAQEVVIRASGREDLSLEAWTVARKAGLFEQTFRRTVQVIVDAGDDASVSARA
>NZ_CP011125.1|WP_157070407.1|1777625_1778456_-|SDR-family-NAD(P)-dependent-oxidoreductase
MGTWAPPDLRGKVCVVTGASRGVGKGIALGLGEAGATVYVTGRTEHAGALPGTIGETADAVRALGGVGIAVRCDHANDDEVEALFARVDAEQGRIDVLVNNAFAIPEGELTAPFWQLPIAQWDVMHRVGLRSHYVAAWHAAQRMVPARRGLIVNVSSFGAKIQAVNVAYGVGKAGVDRMSRDMGRELAPQGVTAVSIWPGIVKTERLLLEPERLGFDPSKGESPHFSGRAVACLAADPRAIERAGEALVVAEMGEHYGFPDVDGSRPRSMRRDRAR
>NZ_CP011125.1|WP_053231728.1|1778470_1779628_-|acyl-CoA-dehydrogenase-family-protein
MTSQLDATLLSRAEDAARAIAPLAARIEAERQLPPEAIDALVRAGALKLLVPRAHGGAEASAETFLAVVETIARADGSAGWCTMIAGGSGLMSMFLAPDVAREIYAPDDAITCGVVAPMGRAARVEHGYRVSGRWPFGSASKHAQWIMGGTIAEGDAPLPSGAPDIRSVLFRASDVQILDTWDVSGLRGTGSHDFAVKDVVVPAERTFSLITTKRTHEGPLARLPFFGTLAAGVAAVSLGIGRAAIDALIALATKKSPLGAKQTIAHRETVQLEVARIESRLRGARAFLFDALGEAGREIARDGEATVRTRALLRAAACHAASESARVVTSAYELGGGTSIYASSPLQRHLRDVHTASQHLMVAQPTATTAGRVLLGLETDTATL
>NZ_CP011125.1|WP_053231729.1|1779653_1781273_-|NTP-transferase-domain-containing-protein
MNELERIVAEASRIDGAPRLLATVVRVRGSSYRRPGARMLVAGDRWVSGCVSGGCLEGDVMLRGWHRCRGGPVVVTYDSTSDEGAPWGVGLGCDGVVDVLLEPGDTNDALTFARACFAAETSGVLVTVIGGASVGARVAIGPEITLARPVDDPALRAALVRAASGPPGVVEVGDVTALVEVIAPSPQLFVLGSGHDVTPIVTAAQSAGFRVTVADRAIRERSRLLAADHVIATGGDLTELASRIDAAREAYVVIMHHQVDADRAALAMSLRSRARYVGLLGPARRTRALLTAIGAEHDARVHAPVGLDIGAETPEQIALAVVAEMCAVARGRRGGMLRERARAMHQEVAFVVLAAGGSTRLGRPKQLVELAGVPLVRRVAQTCLAVGGGPVGVVLGASSDTVAGALDGLRLARIENDGWREGIASSIRAAVAWAQARACGALTIVLADQPRIASSHLIALRDAWARGAPIAATRWRDDARDIVGAPAIFDRARWDALCALTGDRGAGALLRAEDVIAIDCADAALDVDTPDDVCALLGA
>NZ_CP011125.1|WP_053231730.1|1781269_1783396_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MIGAPLSRVEGPLKVSGRATYGYEDWSFGPTLYGFVVEATIARGRITSIDTSVAERAPGVRRVLTHRDAPPQGEPDPSASSYARAMPVLKDTEIRAFAQPVALVVARTFEDARAAARLVRITYEITPGEYELDEPGAPEIEQKSVNAGYSADSSIGDLDGALASAPVVLDRVYTTPYAFSLPMETHACIAAWDGDTVIAHCSTQIVADARQRIASTLRLDPEKVRVLSRYVGGGFGSKLGVSVETILAVMAARIVGEPVKVTLTRQQMFHLTGHRPASRQRVRLGASRDGRLHAFGHDAVQKQTRGSDYVEQTATAGRSLYAAPNRRTTHRSIALDLPVAGDVRAPGEAPGLFAIESAMDELAYTLDVDPIALRIANEPTIHPELNIPYSDRRMVECMREGARRFDWNRRARIPASTRDGRWLVGLGMAAAIRPHYQSESHVRVRVEPDGTVRVQCDMTDIGTGTYTVLAQTASEALGVPVDRVRVELGDSALPRTAGSGGSWGATNSCTALLRACRTLREKLGAPSGDVRAHVGASAVDAIGSVPEQTEEPSFSKSSIASYGAHFAEIGVDVDTGEVRLRRMLGVFDVGRVFNAKTARSQLIGGMIWGVSMALHEEGLVDPRVGAFVNRDFAQYLVPVHADIPAVDAIILDGFDGAANELGAKGVGEVGNCGASAAIANAVYSATGVRVRDLPITIEKLLPHLPARS

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Crispr_ID: NZ_CP011125_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_8

1943642-1943760

Orphan

Consensus_repeat	Method
CGCGGCCCGCCGCTCGAGTCGCAAGCGGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_8

>merge|NZ_CP011125|8|1943642-1943760|CRISPRCasFinder
CGCGGCCCGCCGCTCGAGTCGCAAGCGGGTGGGGACCCGCGCGCAGCTCGGGGGTGCGGGGGGCGGCGCACCGGCCATCGTGCTCGCCACGCGGCCCGCCGCTCGAGATCGCAAGCGGG

>NZ_CP011125|8|6|1943642-1943760|CRISPRCasFinder
CGCGGCCCGCCGCTCGAGTCGCAAGCGGGT	GGGGACCCGCGCGCAGCTCGGGGGTGCGGGGGGCGGCGCACCGGCCATCGTGCTCGCCA
CGCGGCCCGCCGCTCGAGATCGCAAGCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_157068839.1\|1938639_1939038_-\|response-regulator	unknown	unknown	gnl\|CDD\|381118
NZ_CP011125.1\|WP_053231846.1\|1938289_1938643_-\|response-regulator	unknown	unknown	gnl\|CDD\|381116
NZ_CP011125.1\|WP_053231857.1\|1950211_1951144_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176163
NZ_CP011125.1\|WP_157068841.1\|1940782_1941502_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|259988
NZ_CP011125.1\|WP_053238731.1\|1936525_1937647_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340888
NZ_CP011125.1\|WP_053231848.1\|1939408_1940014_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369297
NZ_CP011125.1\|WP_053231851.1\|1941554_1943435_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057
NZ_CP011125.1\|WP_053231855.1\|1946151_1948329_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NZ_CP011125.1\|WP_157068842.1\|1953006_1953729_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070408.1\|1948371_1949673_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|163503
NZ_CP011125.1\|WP_053231854.1\|1945593_1946109_-\|peptide-deformylase	unknown	unknown	gnl\|CDD\|234668
NZ_CP011125.1\|WP_053231845.1\|1937878_1938253_+\|response-regulator	unknown	unknown	gnl\|CDD\|381100
NZ_CP011125.1\|WP_053231858.1\|1951247_1952120_+\|aldo/keto-reductase-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236676
NZ_CP011125.1\|WP_157068838.1\|1934948_1935146_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_083457239.1\|1935313_1936459_-\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NZ_CP011125.1\|WP_053231859.1\|1952281_1952599_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378964
NZ_CP011125.1\|WP_157068840.1\|1940027_1940411_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053231853.1\|1944622_1945594_-\|methionyl-tRNA-formyltransferase	unknown	unknown	gnl\|CDD\|234567
NZ_CP011125.1\|WP_053231852.1\|1944056_1944626_-\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	unknown	unknown	gnl\|CDD\|376665
NZ_CP011125.1\|WP_053231861.1\|1953725_1953998_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_157068839.1\|1938639_1939038_-\|response-regulator	gnl\|CDD\|381118	cd17580, REC_2_DhkD-like, second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains. Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	9.39785e-21
NZ_CP011125.1\|WP_053231846.1\|1938289_1938643_-\|response-regulator	gnl\|CDD\|381116	cd17574, REC_OmpR, phosphoacceptor receiver (REC) domain of OmpR family response regulators. OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.16309e-24
NZ_CP011125.1\|WP_053231857.1\|1950211_1951144_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176163	cd08474, PBP2_CrgA_like_5, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 5. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.97582e-94
NZ_CP011125.1\|WP_157068841.1\|1940782_1941502_+\|hypothetical-protein	gnl\|CDD\|259988	cd13921, Amicyanin, Amicyanin is a type I blue copper protein that plays an essential role in electron transfer. In Paracoccus denitrificans bacteria, amicyanin acts as an intermediary of a three-member redox complex along with methylamine dehydrogenase (MADH) and cytochrome c-551i. The electron is transferred from the active site of MADH via the amicyanin copper ion to the cytochrome heme iron. The electron transfer from MADH to cytochrome c-551i does not involve a ternary complex but occurs via a ping-pong mechanism in which amicyanin uses the same interface for the reactions with MADH and cytochrome c-551i.	0.00121823
NZ_CP011125.1\|WP_053238731.1\|1936525_1937647_-\|MFS-transporter	gnl\|CDD\|340888	cd17330, MFS_SLC46_TetA_like, Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.04422e-63
NZ_CP011125.1\|WP_053231851.1\|1941554_1943435_+\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	1.38113e-09
NZ_CP011125.1\|WP_053231855.1\|1946151_1948329_-\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	0.0027433
NZ_CP011125.1\|WP_157070408.1\|1948371_1949673_-\|hypothetical-protein	gnl\|CDD\|163503	TIGR03791, TTQ_mauG, tryptophan tryptophylquinone biosynthesis enzyme MauG. Members of this protein family are the tryptophan tryptophylquinone biosynthesis (TTQ) enzyme MauG, as found in Methylobacterium extorquens and related species. This protein is required to complete the maturation of the TTQ cofactor in the methylamine dehydrogenase light (beta) chain.	5.41041e-09
NZ_CP011125.1\|WP_053231854.1\|1945593_1946109_-\|peptide-deformylase	gnl\|CDD\|234668	PRK00150, def, peptide deformylase; Reviewed.	6.56336e-80
NZ_CP011125.1\|WP_053231845.1\|1937878_1938253_+\|response-regulator	gnl\|CDD\|381100	cd17548, REC_DivK-like, phosphoacceptor receiver (REC) domain of DivK and similar proteins. Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	9.58256e-35
NZ_CP011125.1\|WP_053231858.1\|1951247_1952120_+\|aldo/keto-reductase-family-oxidoreductase	gnl\|CDD\|236676	PRK10376, PRK10376, putative oxidoreductase; Provisional.	0
NZ_CP011125.1\|WP_053231848.1\|1939408_1940014_+\|hypothetical-protein	gnl\|CDD\|369297	pfam07274, DUF1440, Protein of unknown function (DUF1440). This family contains a number of bacterial proteins of unknown function approximately 180 residues long. These are possibly integral membrane proteins.	0.00202244
NZ_CP011125.1\|WP_083457239.1\|1935313_1936459_-\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	1.74503e-56
NZ_CP011125.1\|WP_053231859.1\|1952281_1952599_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378964	pfam12833, HTH_18, Helix-turn-helix domain.	1.97111e-18
NZ_CP011125.1\|WP_053231853.1\|1944622_1945594_-\|methionyl-tRNA-formyltransferase	gnl\|CDD\|234567	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed.	2.44096e-137
NZ_CP011125.1\|WP_053231852.1\|1944056_1944626_-\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	gnl\|CDD\|376665	pfam01923, Cob_adeno_trans, Cobalamin adenosyltransferase. Cobalamin adenosyltransferase This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation.The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12.	5.05873e-81

>NZ_CP011125.1|WP_053231851.1|1941554_1943435_+|hypothetical-protein
MILSRVWYLLLAIAAVMGLAFAMVSVRLLDERSEEAVRDALRRDRFELEAILKLDARSRIDAMAPLAAHGDVRSALREATGRREGQDIDAAVVQRLTTRLTELNRQLEGMAGDLVIATDANGIIVGQLGGPTVPRGAGVGGFPLVRRALDGYVRDDVWIFNGEVYRMAARPVIDGGQYVGAIIHGKRIDAQFAQLLAGPNRIAGASVGFFRGPEVFASAMAGQELLPPGTSAPRQDDIAAPLETVIAQLAEGDRSEPTELPTGGLAVYSFVVGSAGQAQVGYAIARPVPTTGSPLAIFSLPSSQDWTEFLGSGLGMGVIALGLLAFLIGLLFVWLEHDRPLGKFRDATARLAKREVDKLIPVEFAGQLRTAAAHVNETIEKIEATAATAPKRRAADLDEILGPVPEQSSPAFFGFAGGGGGGEAAEIPPAPPAAPEPAKPIAPPSPKEEAKPAAPPPPKPPVPAAGPKPPPPKPPGSAQAVTPAPAPSLGSTLLGMPAEPVAAGSGPVQAPRKVEAPLPALGPEEPDDEDGATMVARVPQELLAKAAGGGDSDAEQEAHFKEVFEQFVATKKECGEPTAGLTYDKFVVTLRKNRDQILKRHDAAKVRFTVYVKDGKAALKATPIRD
>NZ_CP011125.1|WP_157068841.1|1940782_1941502_+|hypothetical-protein
MLAILGIPAVGLAVDVRGTLTVPSDLASQTTPVETDAQRARARYWEEWNGVLDPRPTRLDVAREIAVVLTGPGAPSEGEQPPYRVHNGTLTPATLVVRAGTAIQIRNDDGVAYELFAEGLSDFGAIQTAPGNARPVTVPQPGNWPVRDRVHPHIRGHLHAIPDLVARGFVEPNGAYTFRGVAAGTYQLHVFQGARELHTQEIVVPESGQLTVPAIPLSSSPPPPSAPQPSSAPQGAAAP
>NZ_CP011125.1|WP_157068840.1|1940027_1940411_+|hypothetical-protein
MAARFVYYFGPAKPGIEADMSKLSDFLSTNKIDSRRVVLASKDIEQRTAEDRKLVATKKAMKDGKAEKDEAVLKQKPRSGRPVTGAAMTKALGGQTVSGPVKTRIVKAVNAVLTQKKKPEITLRDLF
>NZ_CP011125.1|WP_053231848.1|1939408_1940014_+|hypothetical-protein
MERDPASVVSAILKGAIAGAIGVWVLDRVSTALYEREGEAEREREAHARPGGLDPTRNVVTRVAAARGMTLTGDALDRPALGVHYALGVVPGALYALARGGRGVSPLAGAALGLALFVVNDEVLNTAMRLAGPPRAYPWQAHARGLVAHLAYGIATDAALGLAQRLSAPCVEARVAPMPDVSEERPDLTPDMAIPPAPLAS
>NZ_CP011125.1|WP_157068839.1|1938639_1939038_-|response-regulator
MTSSPMTIVVIEDHADSLEMICEVLELRGLVAHGFSSGAAAWAAIAQSAPDVVMTDLRMGTMSGIELAKLVRNEPSLDGVALVALSGDVPELQRHQSDGLFDMLLAKPVDLVELPQRLEALRGRRAARVVDR
>NZ_CP011125.1|WP_053231846.1|1938289_1938643_-|response-regulator
MSVLVVEDNDDVRELVAMVLTDAGFEVLEASDGARALDVLRNAPVPPCVVLLDVMMPRMDGYGVVAALREEPRLAHVPVVFVTADQHAREVDGVLEVVRKPVAPAALVDLASRFCRC
>NZ_CP011125.1|WP_053231845.1|1937878_1938253_+|response-regulator
MSRTPPPTVLIVDDFADARALLRTLLEARGYHTVEASDGQEAIALARDVRPRVVLLDLGLPVLSGWEVARVLREDPATSHACIVACTAYSRPSELEHAREAGCAHVLTKPIDFDALLELLASIA
>NZ_CP011125.1|WP_053238731.1|1936525_1937647_-|MFS-transporter
MIGFGIVIPLLPLYVRSMGGDAQTVGTLLGAFSLTQLLATPVLGRLSDRVGRRRVIAVSLLGNALSMVVFALAASREMLPLLFASRILAGATAGNLSACQAAVADVTPERDRARAMGVVGAGIGLGMVLGPVLGGVLSEHGAWVPPLVAGALAAVDLALVLVLMPETHVQRDVPASHEGVLARARASVGRPGVPRVLALYFLVFLGMTNVQVALPLLVGARFSWDATDVGHVFALLGLATLVTQLFLIGRLSRALGDALLLALGAALLGGGLATVALGAIPVVLLAGVLAIGLGLGMTNPALGALAARLAPAEARGAVLGLAQSSGGLARTVGPVWSGMLFARLAPSAPFLAGAIAAAVALVLALALRARSGP
>NZ_CP011125.1|WP_083457239.1|1935313_1936459_-|pirin-family-protein
MSESRSTRRDVLKVIAAASAAAATGCAPASGGATHRASRGAAPRESAFVSATPLGALWETRDPFLFCAHHDDRYPAGNERLGPDASLAGHDIGSDFEGVDGWRMYHGDVVPGFPEHPHRGFETVTVVREGLLDHSDSMGATARYGAGDVQWLTAGRGIEHAEMFPLLEREGPNPLELFQIWLNLPSADKMTAPHFSMLWGDRIPRHVARDEQGRETRVTVVAGTLGSARPPSPPPSSWASREGSDVAIWTIELAPHATWTLPAARRGSNRDAYFFEGSTLRIDDREVERGHRIELRAELATTIENGPERSELLLLQGRPIGEPVVKYGPFVMNTRDEIRQAIDDYQRTRFGGWPWGRRDPVHAREQGRFARHADGRVERPA
>NZ_CP011125.1|WP_157068838.1|1934948_1935146_-|hypothetical-protein
MKNYWWVLAITLALPLLAGCEDRRGTGMGMGEEEEEVEVEKPSGGVEYEEDVEEYDVEREPGGGL
>NZ_CP011125.1|WP_053231852.1|1944056_1944626_-|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase
MKIYTKTGDAGQTGLFGGDRVSKACPRVEAYGDVDELNSVLGIVRAEGAIGGRFDELIASIQSRLFDLGAELANERGKDLGIPLVDEDDVVAMEHAIDHAEGELAPLRTFVLPGGSKLAAHLHLGRTVCRRAERRVVALMESGATVRPEVIRYLNRLSDLLFVLARLANHRASIADVPWIGRGTQKRSG
>NZ_CP011125.1|WP_053231853.1|1944622_1945594_-|methionyl-tRNA-formyltransferase
MTRPRALFFGTPQFAVPCLDALCDVADVVRVISQPDRPAGRGLAEQAPPVKQRAIERGIPVMQPTKVKPPELAAELKALDVEVALVVAYGRILPKGLLEAPRRGCVNVHASLLPRWRGAAPIQWAVAEGDAESGVCLMEMDEGLDTGPVFARAATPIGADETAGELGPRLSAMGAELVRAALPRWLAGELRAEAQDPSGVTLARLLTKEDGFVDLGWSAQQVHDRARGMHPWPGASAMLVEPGRAPVRVKLHRTRVLEREGVHGAPGAIVAAGGNGIEIACGTGRLALLELQLEGRKKLGAAEFLAGRRLAEGTRLIREGSEP
>NZ_CP011125.1|WP_053231854.1|1945593_1946109_-|peptide-deformylase
MAIRTILHYPDKRLRIPGERVTDFGPELQTLVDDMAETMYAAPGVGLAATQIGVALRVFIIDVATGDDEPSDLRVFVNPEILERNGEVVWEEGCLSFPGVHEEIDRAERVKVRAQDRNGQVFELEADGLLAVAVQHENDHLEGKLMVDHLGMLKKRMVHRQMMKRAADAAE
>NZ_CP011125.1|WP_053231855.1|1946151_1948329_-|hypothetical-protein
MPSRIDLVDPGPDGEALAAGLRAAGFDVALRAMPEVPRTQADALVLAGDAPSALETLRALRDDGVSPDTPVVLLGTPLGTAHRGEGGAGFGAQAVLLRPIALGALVDTLSRVLAPPEEPGSDTSQHRARGERTLELEARTGESIYPRDLDAREVGRDDDELPALASVAPMIPMTPWRQERTPSSSSGSTSSGGTTGDGSSAGVIRGPTAAISERLRLLLEAADRRVFPGRPPVDLSLPGGDEPAIELVPAHLLEGDDFTAPPVATQQSDDDPIDAFTFVGGPVLPSASGLIAELPPPPRAPSASEPPPVPDGEDAPPPKTAPGTPTSLSKRPPPRREPTVPPRASEPPGTGVHSRRVSSMAPMMPEREWPAEDSVLGRATPEGGRRGALGDGGALRLLLRIAELRLDAQVTITPSSGEALAMTLVAGEVARIETPVARGAAAILRRRGAGVGLADDEASAVRALDDAQERGAITRFERARAMREAHLERLRAVVALERGSFVLTRLEPNELPPPAPSPLGAPLRLALLDAARRGLDASRARAVLGGLVTLRRGPRFDALAIEGLIAPELAELLAQHEGASPERLVAAAPDEPGLHGVVCALVAAGALVAQPALELDVARDEHRRLARRLIEEAARTAEDADYFTILGVAHDATARDLDRAHTARRDQLLALALEDLDLSSLEALRRGALESLEEAYRVLSDPRWREAYARALSHTERLATTVGEH
>NZ_CP011125.1|WP_157070408.1|1948371_1949673_-|hypothetical-protein
MTAALLGCDGELGGSPASSRSDVDGDPVVDNATRLVEEGREIFRFDTFGDEAFWGDQLQLHRAIAGAENGGVGPGLTPTAALGLGLKVDAAAIPAALAASIQAGEVDLEDPATTLALLRIDAVVGVQGFFADDGSLRSVGITCAICHSTVDDSFAPGIGVRRDGWPARDLDIGRIVALAPNLTPIAELLQVDVETVRTVLTSWGPGKYDAELLLDGRAFRPDGGSGATVLPAAFGLQGVNLHTYTGWGSVPYWNAFVANTQMHGIGNFYDPRLDDATRFPVAARARLGHISRPPSEDRITPKLPALHAYQMALVVPTPPAGSFDPAAAARGRVVFEGPARCASCHVPPLFTEPGWNMHTPEEIGIDDFQASRSPDGRYRTTPLRGLFTRMRGGFYHDGRFATLEDVVAHYERVFSLGLDDAERRDLVEYLKSL
>NZ_CP011125.1|WP_053231857.1|1950211_1951144_-|LysR-family-transcriptional-regulator
MDDLADLTAFLAVAREGGFRSAARVTGTSASRLGDAVRRLEARLGVRLLHRTTRSVTTTDAGARLLERITPALGEVRAALDVVNDFRDRPAGRLRLNVPTAAARLVLPHVVPAFLAKYPDIQLEVSADERLVDTVAEGFDAGIRYEAWLEKDMVAVPIGPRVQRFAAAASPAYLARRGRPTHPRELLEHDCLRWRFTRGAPHPWDLERDGETITVDPKGPLIAGFGGATDLAVAAAVAGTGIIYLFEDWLRPFLDRGELVPVLQPWWRSVSGPFLYYPGRRHLPAPLRAFVDFVRSMEPTQPRARRRAAR
>NZ_CP011125.1|WP_053231858.1|1951247_1952120_+|aldo/keto-reductase-family-oxidoreductase
MPEHTVVDRHPLGTLTVRRLGYGAMQLAGPGVFGPPADRRAAVAVLREAVERGVDHLDTSDVYGPHVTNQIIREALHPYRDGLVIATKVGAVRGPGGSWEAAASAADIERSVYDNLRNLGLDVLDVVNLRVMYRAEGPAEGSIEAPLTALAELQRRGLVRHIGVSNVTPAQIAEARRLTEIVCVQNHYNLRHREDDPVIDELAALGIAYVPFFPLGGFTPLQSRTLDAVAARLGATPMQVALAWLLRRSPNVLLIPGTSSIAHLRENLASASLVLGADDVETLDGLSARA
>NZ_CP011125.1|WP_053231859.1|1952281_1952599_-|AraC-family-transcriptional-regulator
MAELTRVTGVSVRSLQEGFRRSRGCSPLTFARTRRLERARVLLLTHDDALTVSEVAQRVGIPHFGRFSVYYRQRFGETPTQTLGRSFGARSTQGETQVGTAPAAP
>NZ_CP011125.1|WP_157068842.1|1953006_1953729_+|hypothetical-protein
MLGDDGELWTYDPTTHDFALVTASLGCAGGSLFSMAIGRDGIAYLMFINGDIQAIDVNDPTSCVDPGYATGQPGFGLFGMGFASNSALDPCDKLYAHTWNGIGGFSQGPDAGRLGRMDADELVLTEIGLIDYNGGELTGTGDGRLFAFAGAPAQIIEYDKDTAEVIATDSLAMNLTNAFAFAFYGGDFILFTESDGDPSYSNVTRFDHDGDGSLTTVVTQAPIRVVGAAVSTCAPLVAAP
>NZ_CP011125.1|WP_053231861.1|1953725_1953998_-|hypothetical-protein
MITTLSRGELVAQGAALRSSYLVQQAGYTLGIAALDEAGIAAILGDRSLLEDVATAKTARADRSLVAEEAKARTVGQSEHVRDAKAHPAN

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Crispr_ID: NZ_CP011125_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_9

2174895-2175033

Orphan

Consensus_repeat	Method
GAGCGAGCCGCGTGAGCTCGGATGGCTCGAGTTGCGCAGCTCTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_9

>merge|NZ_CP011125|9|2174895-2175033|CRISPRCasFinder
GAGCGAGCCGCGTGAGCTCGGATGGCTCGAGTTGCGCAGCTCTGAGGAGTTGCCGCTAAGGAGAGCAGGAGGAGCAGGAGGGGATTCGCGCGATGAGCGATCCGCGTGAGCTCGGATGGCTCGAGTTGCGCAGCTCTGA

>NZ_CP011125|9|7|2174895-2175033|CRISPRCasFinder
GAGCGAGCCGCGTGAGCTCGGATGGCTCGAGTTGCGCAGCTCTGA	GGAGTTGCCGCTAAGGAGAGCAGGAGGAGCAGGAGGGGATTCGCGCGAT
GAGCGATCCGCGTGAGCTCGGATGGCTCGAGTTGCGCAGCTCTGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053232029.1\|2167294_2169016_-\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349895
NZ_CP011125.1\|WP_053232027.1\|2165825_2166470_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP011125.1\|WP_053232039.1\|2177203_2177929_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP011125.1\|WP_053232040.1\|2178130_2179726_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157068881.1\|2170990_2171692_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238744.1\|2176566_2177115_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP011125.1\|WP_053232037.1\|2175212_2175629_-\|GxxExxY-protein	unknown	unknown	gnl\|CDD\|275083
NZ_CP011125.1\|WP_053232028.1\|2166529_2167294_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368243
NZ_CP011125.1\|WP_053232033.1\|2171755_2172088_-\|thiol-reductase-thioredoxin	unknown	unknown	gnl\|CDD\|200072
NZ_CP011125.1\|WP_053232043.1\|2182502_2183318_+\|matrixin-family-metalloprotease	unknown	unknown	gnl\|CDD\|334067
NZ_CP011125.1\|WP_157068883.1\|2180980_2182384_-\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|372685
NZ_CP011125.1\|WP_053232036.1\|2173997_2174759_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133405
NZ_CP011125.1\|WP_053232031.1\|2170583_2170889_+\|YfhL-family-4Fe-4S-dicluster-ferredoxin	unknown	unknown	gnl\|CDD\|319871
NZ_CP011125.1\|WP_053232045.1\|2184093_2185455_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053232034.1\|2172161_2172647_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_CP011125.1\|WP_169791384.1\|2183289_2184042_-\|response-regulator	unknown	unknown	gnl\|CDD\|381110
NZ_CP011125.1\|WP_053232030.1\|2169077_2170496_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|273453
NZ_CP011125.1\|WP_157068882.1\|2179830_2180739_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|223810
NZ_CP011125.1\|WP_053232038.1\|2175978_2176449_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NZ_CP011125.1\|WP_053232035.1\|2172759_2173923_+\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|239583

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053232029.1\|2167294_2169016_-\|M28-family-peptidase	gnl\|CDD\|349895	cd05643, M28_like, M28 Zn-peptidase-like. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They typically have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This protein subfamily conserves some of the metal-coordinating residues of the typically co-catalytic M28 family which might suggest binding of a single metal ion.	9.36251e-36
NZ_CP011125.1\|WP_053232027.1\|2165825_2166470_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.73543e-09
NZ_CP011125.1\|WP_053232039.1\|2177203_2177929_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.28191e-15
NZ_CP011125.1\|WP_053238744.1\|2176566_2177115_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.42944e-16
NZ_CP011125.1\|WP_053232037.1\|2175212_2175629_-\|GxxExxY-protein	gnl\|CDD\|275083	TIGR04256, conserved_hypothetical_protein, GxxExxY protein. Members of this protein family average about 130 residues in length and include an almost perfectly conserved motif GxxExxY. Members occur in a wide range of prokaryotes, including Proteobacteria, Perrucomicrobia, Cyanobacteria, Bacteriodetes, Archaea, etc.	3.66187e-48
NZ_CP011125.1\|WP_053232028.1\|2166529_2167294_+\|hypothetical-protein	gnl\|CDD\|368243	pfam05019, Coq4, Coenzyme Q (ubiquinone) biosynthesis protein Coq4. Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway. The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).	1.25387e-36
NZ_CP011125.1\|WP_053232033.1\|2171755_2172088_-\|thiol-reductase-thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	3.04493e-23
NZ_CP011125.1\|WP_053232043.1\|2182502_2183318_+\|matrixin-family-metalloprotease	gnl\|CDD\|334067	pfam00413, Peptidase_M10, Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.	2.37658e-10
NZ_CP011125.1\|WP_157068883.1\|2180980_2182384_-\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|372685	pfam13715, CarbopepD_reg_2, CarboxypepD_reg-like domain. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.	3.92593e-09
NZ_CP011125.1\|WP_053232036.1\|2173997_2174759_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133405	cd04778, HTH_MerR-like_sg2, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 2). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	2.39747e-31
NZ_CP011125.1\|WP_053232031.1\|2170583_2170889_+\|YfhL-family-4Fe-4S-dicluster-ferredoxin	gnl\|CDD\|319871	cd10549, MtMvhB_like, Uncharacterized polyferredoxin-like protein. This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.	1.12849e-06
NZ_CP011125.1\|WP_053232045.1\|2184093_2185455_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.48225e-96
NZ_CP011125.1\|WP_053232034.1\|2172161_2172647_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.95979e-20
NZ_CP011125.1\|WP_169791384.1\|2183289_2184042_-\|response-regulator	gnl\|CDD\|381110	cd17562, REC_CheY4-like, phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins. CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	6.64045e-11
NZ_CP011125.1\|WP_053232030.1\|2169077_2170496_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|273453	TIGR01125, Ribosomal_protein_S12_methylthiotransferase_RimO, ribosomal protein S12 methylthiotransferase RimO. Members of this protein are the methylthiotransferase RimO, which modifies a conserved Asp residue in ribosomal protein S12. This clade of radical SAM family proteins is closely related to the tRNA modification bifunctional enzyme MiaB (see TIGR01574), and it catalyzes the same two types of reactions: a radical-mechanism sulfur insertion, and a methylation of the inserted sulfur. This clade spans alpha and gamma proteobacteria, cyano bacteria, Deinococcus, Porphyromonas, Aquifex, Helicobacter, Campylobacter, Thermotoga, Chlamydia, Streptococcus coelicolor and Clostridium, but does not include most other gram positive bacteria, archaea or eukaryotes. [Protein synthesis, Ribosomal proteins: synthesis and modification].	2.45731e-160
NZ_CP011125.1\|WP_157068882.1\|2179830_2180739_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|223810	COG0739, NlpD, Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane].	1.41722e-34
NZ_CP011125.1\|WP_053232038.1\|2175978_2176449_-\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	1.04557e-14
NZ_CP011125.1\|WP_053232035.1\|2172759_2173923_+\|fatty-acid-desaturase	gnl\|CDD\|239583	cd03506, Delta6-FADS-like, The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity. While HUFAs may be required for cold tolerance in bacteria, plants and fish, the primary role of HUFAs in mammals is cell signaling. These enzymes are described as front-end desaturases because they introduce a double bond between the pre-exiting double bond and the carboxyl (front) end of the fatty acid. Various substrates are involved, with both acyl-coenzyme A (CoA) and acyl-lipid desaturases present in this CD. Acyl-lipid desaturases are localized in the membranes of cyanobacterial thylakoid, plant endoplasmic reticulum (ER), and plastid; and acyl-CoA desaturases are present in ER membrane. ER-bound plant acyl-lipid desaturases and acyl-CoA desaturases require cytochrome b5 as an electron donor. Most of the eukaryotic desaturase domains have an adjacent N-terminal cytochrome b5-like domain. This domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain the residues: HXXXH, HXX(X)HH, and Q/HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homolog, stearoyl CoA desaturase.	1.61911e-21

>NZ_CP011125.1|WP_053232036.1|2173997_2174759_+|MerR-family-transcriptional-regulator
MSSSEASAAEPEYTIDELARESRVPSRTIRFYQSKGVLMAPVLRGRVAYYGPKHLERLELIAQLQDRGLKIDTIRELAARLDKGEIDVADWLGLDAQLRAPWAEDRPRTVTEAQLIELAGAKRPGLVADLVRTGGVERHGDVFLVRSPALLQVAMKLEGAGVDLEVATKAADILRRHLAKAAKDLTDHFLSHAGRILEGEYEGDLGRAVEALRPLGLDAVRIVFAQEMEKALAALRDSGRAARLPTRKKKKIR
>NZ_CP011125.1|WP_053232035.1|2172759_2173923_+|fatty-acid-desaturase
MELAHFETDPRSLPDAERLRRFGDELDAIKARVEAEIGAEDLAYVRRMHRFSRTMEVLGRVLIHVSPEPITWSAGVIALWIHKQLQATEIGHTVLHGAYDRIEGNGKFDSKKWWWRVPIDEESWRYGHNVRHHGATNVAGKDADIHFGPVRLTEQTPHRAEHRFQLLFALAVLFPNFGFLMNLHFTGLNDLHWDNGLPGGEKQLDFIPDRSPESRRLAWKRALRKYVPYYAYEYGLFPLLAGPFFWKVLLGNWLSDTMRDVYSAATIFCGHVGERTKSYDPGTKSKSRGEWYAMQIEASNDFEVPWVVSVLCGGLDRQIEHHLFPKLAPQRLRAIAPEVRALCEKYGVDYRTGSWPQVLRDALRWIDTLSRDHGAIGGARAALAAMA
>NZ_CP011125.1|WP_053232034.1|2172161_2172647_+|sigma-70-family-RNA-polymerase-sigma-factor
MDPVIDSLVRTHRRTLVAIARREGLGPEEALECVQDALCTFLSLPHPPHDHALAAICVMVRNAARNVRRRHHRLRIHDPIADELAAPCADAESLVSRAEDVARLRSCVAALRGPQREVVLLRLLEERSGEDVAAELGLARGHVDVLVHRAKRSLRACMNDR
>NZ_CP011125.1|WP_053232033.1|2171755_2172088_-|thiol-reductase-thioredoxin
MTKHLISVDDLGFDVDVLGSELPVLVEATSRWCGPCRAQHVILERIAAQLAGRVRVVLLDIEQAPVTTVRLGIRGTPTIMLFAGGREIARQTGLTPETIVRRMIEPALAA
>NZ_CP011125.1|WP_157068881.1|2170990_2171692_+|hypothetical-protein
MIAAGCAAPQPMMLGGRTTPRDRVDLGVGGAARIPLGDLQPPETPDGDEQVLHYAESGGIAPIAWGRWGLADDWDLGLFVSGSVVRLETLGELRLSPFLRLIGGVMPYGGYARADVPEPATMSTRTSEGWRVGALAPIAIGIEAGGVFEGWLGARVGFEHADGSFGPAEMRTSGALTAFRGGLVLGLGLGLRRVHVLIELAADYEYWRGGIGEDDIERHGVALTPGFALRLRL
>NZ_CP011125.1|WP_053232031.1|2170583_2170889_+|YfhL-family-4Fe-4S-dicluster-ferredoxin
MATHITSDCINCGACEPECPNQAISEGTDIYVIDPNLCTECVGFYDHEACQAVCPVECCLPDPNRPESEDVLIERAVHLHPEDEQLKSRASANDYPSRFRK
>NZ_CP011125.1|WP_053232030.1|2169077_2170496_+|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MAADRTIHFVSLGCPKNRVDTEVMLGVSGLEGYRHVDDATDADVIVVNTCGFIGPAKEESIDTILGMSQLKESGSCKTLVVAGCLSQRYPEQLAAEMPEVDHFLGSSDMLKLKDVLDAPGRAPRMLVGNPADHTIRATDPRLPSLGAHSVYVKIAEGCNRSCSFCAIPTFRGKQRSRPIDDVVRECEMLIDRGATELNLISQDTISYGRDLKDGTELAALVQRVADLPGAKWVRLFYLYPETLKPHLVDLIANHPKVLPYVDMPLQHASDRMLKIMRRGHGLDRQRKVVETLRKNVPNLVMRTAFIVGHPGETDADFAELCDFVTWAEFDRVGVFRYSPEEDTRSHAMEDDVPAKVSNARARKLVALQRPISRRKTKAMIGQEVEVLVEGGSEESEFLLRGRWWGQAPEIDGEVHLANGTAKVGELRKALITAAADHDLVADLADEHGELPEPPDGPRRAPRKPRISLRTIA
>NZ_CP011125.1|WP_053232029.1|2167294_2169016_-|M28-family-peptidase
MLAVRDLASVFLLLLAIGCGGAQGAREVAPAFPPPTPRLAANARAVHAHFDPERALATVAYVDRFFRVRGNEGYQSSLRHVQTSLAAQGFDLASMRLVQLGEERATWTPRRARLALIGDGGSETELVAFADESERDRAALLVGSDAMAPVELEVVRIEAVRAGTSARGRLVLAEGEPRPLFRELASRGAVGVLVKNLAPYHRGDDAAQFGYLPAHEGQLGIGFSLSEEDWRALRAATERGIARVRVEIAVRSGRSAATALEARIEGTEPDAGAIVFVAHVDEPGANDNASGVGALAELAVALRRAIEEGAVRPPTRTLVFLWGQEIEVAREWLEREVMPVSAGLVLDMVGQDPTVVGAPFLIERMPDPGAVWLRAPDEHSEWGQSEVDPARLRGHFLNDWLRASIASVQGVEGAAFPARAHPFEGGSDHVAFLERGLPAVLAWHFTDDAYHTTRDRLDRVSGAEMRRVAAVLGGAALSMASGERGDREEMIAVVRAAGLERLAWAEHASREEIASGGALTTERLVIGAWGDWYDEALRSIDAWDGEDEALRAAITEAREAIAARTREAEATLR
>NZ_CP011125.1|WP_053232028.1|2166529_2167294_+|hypothetical-protein
MHDTPSAHKKLRPWHAAPAMWRLLRDPDDTRHVFTIIEALSFRELERTRDRMRASADGRRILRERPDLLASLRDRDALAAMPEGSLGRAYLEFLRAEGITADGLVAASIEGSTDVAPMNADELELLYVGDRLRDAHDLWHVVTGYHGDLLGEASLLAFSFAQTGTPGVGFIAAIGWLKAAAIDARDLIAGGYHRGRTAAWLPDQHWETMLARPLSEVRARLRIAPPPPYEPLRTRDIAPGSLARWERTERPLAA
>NZ_CP011125.1|WP_053232027.1|2165825_2166470_-|TetR/AcrR-family-transcriptional-regulator
MTSRTTKKRASKKESVAPPRVRRSAEDAQRAILDAAEVRLAERGPDSIRLQDVARAVGMSHSTVLHHFGSREALLEAVVKRAMERLTSDMLTSFAAGEDARDPAAMLERVFEAFGGGQARMLSWLRLTGIDVNVDERYLLDVARAAHALRPAGANGKKPPFEDTLFTMILASLAAYADGIAGEPTRRSAGLAGDPGAAKRFRAWLARLLSTHLG
>NZ_CP011125.1|WP_053232037.1|2175212_2175629_-|GxxExxY-protein
MPLEHEEMTRSLIGAAIAVHRALGPGFLESVYAGALALELGARGLSYERERSVPVVYRGVEVGTHRLDLLVAGEIVVELKAVKDVTDSHFAVVRSYLRAVGREHGVILNFAKPKLEAKRVIVTATPRARSAPPRGRSR
>NZ_CP011125.1|WP_053232038.1|2175978_2176449_-|NUDIX-hydrolase
MSELVNAPVRMVYRAAHLALRAYWLVRRPETHGALVALWFRGKILLIRSSYRATYSLPGGYVKSGEDARRAARRELDEELGLALPDDALRHAWAGSFPFEHRTDSLDIFEADLEEPFHVEPNGRELIWAGWKTPEEALAMEIVPHLRDYLDRRTKR
>NZ_CP011125.1|WP_053238744.1|2176566_2177115_+|helix-turn-helix-transcriptional-regulator
MSLSAVLAENVRQLRAARGLTQAQLAKSAGVPRATWANLESGEANPTLHVISAVSRALGVSLEELLSAPRAACVLHPRETLPTKKRGTVTVRNLLPDPLPGSNIDRIELPPGARMTGIPHTPGTREYLTVERGAIVLAAAGERFTLREGDVLAFRGDQRHSYANPSTHETAIGYSVVILVDA
>NZ_CP011125.1|WP_053232039.1|2177203_2177929_+|class-I-SAM-dependent-methyltransferase
MSVVLRFDRARTHSSEDRFHDLAFARIVREIGAKPGDEIFDAGCGDCTNALRFARLGLRVKGVDVSHLALERARSRIARERAERRVSVSHGDVRALRVRDRAFRFASCWSVLMHVPHVERALDELARVLAKHGRLAIMERTCESLQARTWDRAVRLLRRHRLERTARGLEEWREEGLLVRGFDPAWLCEHLDRRGLSLVARFAGQLTEVEPLARVLGDLYFSANAPARFAHGNVFVFEKRS
>NZ_CP011125.1|WP_053232040.1|2178130_2179726_-|hypothetical-protein
MPPIAVIRTERDVYANLLRDTRGLRREQANARDVWFASMPWERKEETLFELEMLLKGLACFGNPRNHPGTPAAKSAVAQDFHEELRILRDASQRVITLTKQLLGDKERAYTFTRYLESVLPEDSARGRLIQEQLTQDTPEEALFVLRNAFGHFLDLSDGLARLGRVSNRLYFAMHGVVVREIGRNAYFNPLMALEFRPEFDRIRSGEVLEALHVVESETAHRVLALTFLALFRALRYVSLVDAYASDPASTRRAYVILAVLRSDLRALTRYLGRRAGDAIADGLERELLATPSDEIGVRYTHLADVARSLTRIRGTLDHVANGLRVEVKKIFEHDLPSPQAEISAQELGPQMVIAAAELRASLQNAVRALCSEIRPGDTLPELAVDLAGRRAASDRLRREIWMFQQILRAFLAKADAAASAGSDGAHDRWAGHGSFQFVRDFLGHFRAIGYQLVRSHDYERLDPFLTSLERLRDVDLLEPHRMAEAVEECRALSQFLGELFEKVSGRAELAGHGFDRQSAGETLKIYLGRA
>NZ_CP011125.1|WP_157068882.1|2179830_2180739_+|peptidoglycan-DD-metalloendopeptidase-family-protein
MIRRWALVLAMWLAVPGMTQAQPRPRTYVVREGDTLARIARRHRSSVEAIREANRLRGDAVRAGQELIVPREGEDPRALRSSRGATPARETPAQREARGRARRIGLGTVRAGQSLLVRAPERRWVAAAGEGPRLSGTLRLPVDRGRLIRGWGSGEGGYHLAIDIRGRVGATIRAAERGIVAYAGDGLSGYGNFVILVHPNGWVTAYAHNRENLVVAGQVVRRGEAIARLGNTGTSQSPHLHFVLVDGGAHCDAVPLFDPPIARSVTSAVWRDERPESVQCLRRSERPHPSHAEEDDERADEP
>NZ_CP011125.1|WP_157068883.1|2180980_2182384_-|carboxypeptidase-regulatory-like-domain-containing-protein
MVRKTRKMPALISTIALIAGCGSSTRAEVTGVVVDARTGRAIPGARVVAHDGSATRTDDEGRFTLSVSRGDARSIRASAAGREDAQTRIDVGVDESASIVIRLVPAHDETPRAEHVVAQYHEEHGTDPDAVLRWIEDVDLERWLVRGVREPEGVETVPCGTCTAWGAREQWALGAMRLAGDTSDGAECASCHDASAFAAAHGETTSIAGDACVACHEGTELRAFEHVDHVAGAPASGLGTGAVCVECHRAPGHAPQADVVLGRGARTLASADVGEAPHGAIADACVACHAAPWREADPAELTLGHTFEVREASGGIARDACSSCHGEVAPESIARGDWDGDGASGAVAEEHDRAVARVRRRLESRVQQARVRARCGTRSSTAVAFTEHAAGGGPGTLVLVDVRGVMLGDCDEDGAFDEDERPVSIDALPRDVRDSMWDLMLLERDGSRGVHNPTFSFALLGAIEARL
>NZ_CP011125.1|WP_053232043.1|2182502_2183318_+|matrixin-family-metalloprotease
MSSTPTRHRSVRTLVTLVAALAISVGAAGRARAYERATVTGDTTPLAWARRDLGLRIAEDTSRDLAPVDVRDAVRRSMTTWTRAGGCTDIVLVDLGTPPDLRTNLLGGAPDLENRVVFREDAWPSELGPETLAITTLVYRRSTGEILDADIDLNALDHSWSVAAVPSLETTDLENTITHEVGHLLGFAHVVDPDATMFASSDPGDVVKRDLATDDVTAVCEVYPASRRTPGGVGPRPPLTSGCAVSSAGGAGVIPVLLGLAALIVRRRRRS
>NZ_CP011125.1|WP_169791384.1|2183289_2184042_-|response-regulator
MSDDPSRPSLEERLAKLRARMEDGLPTRAAELRAAADRLASGDSRAREDIRRAAHRLRGTAGSHGHDALSTEAGEVELLASRDDDCARVVARTLALVASIRRIANESRPVAPVAAPPLVTPSARPLVGRSVLALDDDAPTRRLLELTLVTMGGADARVIEAPDEALVLLDHRAFDVIIVDAMMPTLTGLELVAAARHRAHGANGVFAFLSAATPEELGWTIPPGASWLRKPFRPRELLDALVRIVGGAAR
>NZ_CP011125.1|WP_053232045.1|2184093_2185455_+|protein-kinase
MSGARRSDPDDDELPRTQPRRAGDVPAPETTRPPRARAWDGVPGPGELVADTYRITRVLGEGAMGVVMLARDERLERDVAIKLIHPDYVASPDAHARFVGEARTMARVRHENVVEIYTFGEHRVAGGQRAPYFVMEYVPGITLDARRRAQGVLSIDEVIGVLEQVCRGLGAIHRAGAVHRDLKPTNVLIGPAFRVAVADLGLARVLDRPRDAERDTVSGTPAYMSPEMVRGDVVPAGMHHRADVYSLAVMALELLTGRLPFETDDAVEMMTRHATEAPPRASEIRHELPRAFDEVLLRGMEKDPARRTASADAFRRELLEARDSASQHAGALRLLVADDDEDFAALVRETLDWAFPGAEIVVARDGEQALRELDRHPAALAVLDLDMPGLNGIELTAAIRATSRSERMPILVVTATGGAPDWRLLASLGADGFLVKPIDPMALVALARRTLAR

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Crispr_ID: NZ_CP011125_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_10

2527523-2527614

Orphan

Consensus_repeat	Method
GATCGAGCATCTTCGATGCTCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_10

>merge|NZ_CP011125|10|2527523-2527614|CRISPRCasFinder
GATCGAGCATCTTCGATGCTCGAACGTCGTAGCCGTCGCGCTCAGGCCACGATCTCAGCTCCTTCTCTCGTTCGAGCATCTTCGATGCTCGA

>NZ_CP011125|10|8|2527523-2527614|CRISPRCasFinder
GATCGAGCATCTTCGATGCTCGA	ACGTCGTAGCCGTCGCGCTCAGGCCACGATCTCAGCTCCTTCTCTC
GTTCGAGCATCTTCGATGCTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053232304.1\|2529075_2530464_-\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP011125.1\|WP_053232307.1\|2533670_2534159_-\|YfbM-family-protein	unknown	unknown	gnl\|CDD\|378105
NZ_CP011125.1\|WP_157068934.1\|2527066_2527489_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232299.1\|2519668_2520922_-\|GTP-cyclohydrolase-II	unknown	unknown	gnl\|CDD\|235959
NZ_CP011125.1\|WP_169791406.1\|2534669_2535578_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP011125.1\|WP_053232313.1\|2538627_2539779_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP011125.1\|WP_157068935.1\|2536000_2536663_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791405.1\|2522782_2524825_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|222980
NZ_CP011125.1\|WP_053232297.1\|2517747_2518380_-\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NZ_CP011125.1\|WP_053238760.1\|2525996_2527052_+\|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada	unknown	unknown	gnl\|CDD\|185333
NZ_CP011125.1\|WP_053232298.1\|2518445_2519672_-\|URC4/urg3-family-protein	unknown	unknown	gnl\|CDD\|377948
NZ_CP011125.1\|WP_053232311.1\|2536803_2537121_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232303.1\|2527644_2529009_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP011125.1\|WP_075097875.1\|2517321_2517693_+\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|376605
NZ_CP011125.1\|WP_075097877.1\|2532172_2533687_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP011125.1\|WP_053232302.1\|2524897_2525662_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|180993
NZ_CP011125.1\|WP_053232312.1\|2537499_2538357_-\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|370378
NZ_CP011125.1\|WP_083457297.1\|2514313_2517208_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP011125.1\|WP_053232305.1\|2530694_2532128_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053232300.1\|2520935_2522417_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143404

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053232304.1\|2529075_2530464_-\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.06468e-98
NZ_CP011125.1\|WP_053232307.1\|2533670_2534159_-\|YfbM-family-protein	gnl\|CDD\|378105	pfam08974, DUF1877, Domain of unknown function (DUF1877). This domain is found in a set of hypothetical bacterial proteins.	7.60581e-30
NZ_CP011125.1\|WP_075097877.1\|2532172_2533687_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.33237e-41
NZ_CP011125.1\|WP_053232299.1\|2519668_2520922_-\|GTP-cyclohydrolase-II	gnl\|CDD\|235959	PRK07198, PRK07198, GTP cyclohydrolase II.	0
NZ_CP011125.1\|WP_169791406.1\|2534669_2535578_+\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.45503e-24
NZ_CP011125.1\|WP_169791405.1\|2522782_2524825_+\|hypothetical-protein	gnl\|CDD\|222980	PHA03095, PHA03095, ankyrin-like protein; Provisional.	3.81471e-17
NZ_CP011125.1\|WP_053232297.1\|2517747_2518380_-\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	8.78647e-130
NZ_CP011125.1\|WP_053238760.1\|2525996_2527052_+\|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada	gnl\|CDD\|185333	PRK15435, PRK15435, bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada.	2.819e-141
NZ_CP011125.1\|WP_053232298.1\|2518445_2519672_-\|URC4/urg3-family-protein	gnl\|CDD\|377948	pfam07958, DUF1688, Protein of unknown function (DUF1688). A family of uncharacterized proteins.	0
NZ_CP011125.1\|WP_053232313.1\|2538627_2539779_-\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	4.42274e-84
NZ_CP011125.1\|WP_053232303.1\|2527644_2529009_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NZ_CP011125.1\|WP_075097875.1\|2517321_2517693_+\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	2.53481e-36
NZ_CP011125.1\|WP_053232302.1\|2524897_2525662_-\|SDR-family-oxidoreductase	gnl\|CDD\|180993	PRK07478, PRK07478, short chain dehydrogenase; Provisional.	2.06604e-142
NZ_CP011125.1\|WP_053232312.1\|2537499_2538357_-\|DUF1963-domain-containing-protein	gnl\|CDD\|370378	pfam09234, DUF1963, Domain of unknown function (DUF1963). This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.	1.57273e-30
NZ_CP011125.1\|WP_083457297.1\|2514313_2517208_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP011125.1\|WP_053232305.1\|2530694_2532128_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.68621e-88
NZ_CP011125.1\|WP_053232300.1\|2520935_2522417_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl\|CDD\|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0

>NZ_CP011125.1|WP_157068934.1|2527066_2527489_+|hypothetical-protein
MRALAAALVVVTFVLVPALALAKGPTLPPNESVWQGRYVCAQGVTGLTLTVRPVGADRVSATFSFYAVPENPDVPSGSYTMTGLLSATSEVVQLVPERWVQQPRGYVMVAMSGTFDVAQGVMRGRVDGPGCTEFQLRRMR
>NZ_CP011125.1|WP_053238760.1|2525996_2527052_+|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada
MDAVVMGTEDDARWAAVVARDRAADGTFVYAVRTTGVYCRPSCASRLARRENVEFHRGASEAERAGFRACRRCRPGEASPAERQAARIAEICRVLDDADREHDLDALAASAGMSRFHFQRVFKSITGVTPKAYARARRAERVRSELARGASVTSAMYAAGFRSSGRFYEHSDAMLGMVPSAFREGARSLTIRFAIGACSLGAILVAATDVGVCSILLGDDPDALAAELQERFPHATFEAGEREFDAWVARVVGLVEAPRVGLDLPLDVRGTAFQQRVWAALRAIPVGTTASYADVARAIGMPDAARAVAGACAANPLAVAIPCHRVVRRDGELSGYRWGVERKRELLRRES
>NZ_CP011125.1|WP_053232302.1|2524897_2525662_-|SDR-family-oxidoreductase
MSALFQKVAIVTGASSGIGRAAAKLFAREGAKLVVTARRAHELETLVAEIRDAGGEAIALPGDVTDERHARALVELAVDRFGGLDVAFDNAGASGALGPTSEISLDGWKRTIDTNLTSAFLLAKHQAPALVARGGGSLIFTSTFVGHTVGMPGMAAYAASKAGLIGLVQTLAVELGAQGVRVNALLPGGTDTPAYRAMNASEDAHRFVSGLHALGRVATPDEIARAALWLASDASSFQTGTAMLVDGGISIRRA
>NZ_CP011125.1|WP_169791405.1|2522782_2524825_+|hypothetical-protein
MSDGEVASEDDGAPAETAVDDARASIRVGSLSQRDEERFVLALAAGDRATLDELLATAIDPDVEYPPHGPALHTILTLYAGADVVDVVRSLLDRGADPRVLDERDQSPLHAVVARSVDVRTRGPSNAELVRVLVSRGADVDARDDEGATPLLAQLHAGGGTDVVRALLDAGARVDVRDHAGAAPLHAAIASGAGSLERVQLLVGGGADPRAEVDGTSALELARAMRPRDAELASIERWLSAHLGARSERPADAIALLAQLARERPFAEPPRVGRATAVGAYDASIARLLGAAAGDVVPLSGESRSRASRAPYPRERIAGVDVQVAALVRRGELGARAESLRVEDASLAELSLELGMVETLRALATSPGRAKKHLERWLEHAVSNFLGAEREDLVRVLLDAGADPAAIVSRGRGAYAAPMLQSAAGLDRHATARLLVERFTDARKLVDHVEQALPAACAELGALLRGAHRLAGGAPRGCSLEVKHRSRNVDPERARGVAATREHGAQRVLYFVDAPVAAVAEARAGRAIRSFVDMPDATVPWAARWDAIVGWRGNPWTVVVPHPVPRACEAGSIARALGARVLAVGPAAAIEHASDGSVAAERDGDVDAWCAERGAFMCAYETLRDGLRIGLVLRGVWPEAVERFAVVVHDDGDGTLDARDREVLVALASRLGRSSKRRRS
>NZ_CP011125.1|WP_053232300.1|2520935_2522417_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MKLVDVPAATIRCRNLIAGEWRDASSGETRDVVSPYTGSVVGTVPMSSASDVAAAVESAHHAWQSWRRTPLKERTQLLFRYREILLRDLDLLSHRAALEAGKTVEEARAGIMKGIEVAEFALSLQNLDDGGALEVSRGVTCEVRREPLGVCVGITPFNFPAMVPMWLYPIAVTLGNAFILKPSEKVPLTAVLQAERMLEAGFPKGVFSLVHGGRETVEALVDHPLVAGVGFVGSSGAARAVYTRASNRGARALCLGGAKNVLMITPDADPDVTIPGVVASFTGCAGQRCMAASLLVAVGDVDHLIDGIVERASQVRLGRDMGAIIDHGARERIVHDIDRAVAEGAKLRLDGRAPEAPEGYAQGAWLGPTILDHARADMECATKELFGPVITIVRVKNLEEALAIEASGTYGNACSVFTSSGAVARHVADRATSGMIGVNVGVPVPREPFSFGGTKTSRYGAGDVTGRQGVEHWSWLKKITTKWQMQGDATWMS
>NZ_CP011125.1|WP_053232299.1|2519668_2520922_-|GTP-cyclohydrolase-II
MTTENKPKSRKHIQLTSHPTGEVAMPIRWGNPEPRQRGPVIATLSKPEHRNAIGTHSGAYAVYRALAVAAGSLQADHRSDLTNTAPTDRFGPHAQWGDPERIVSIDPFGAVVQEVFAEQIAQGFDIRPTIAVTKAHLQMHELRDAMDKGRLHADGTVLKASGDVVVTKAAIEPVWWLPGIAKRFGCDEHTLRRTLFEQTGGMFPELVTRPDLDVFLPPIGGHTVYVFGDPSKLGSREHSLTCRVHDECNGSDVFGSDICTCRPYLTHGIEECVKSAQEGGVGLVVYNRKEGRALGEVTKFLVYNARKRQEGGDSAAQYFARTECVAGVQDMRFQELMPDALHWLGITKIDRFVSMSNMKHDALTRSGIEIGERVKIPDELIPADARVEMEAKMAAGYYSAGEVVTDERLRETKGRAL
>NZ_CP011125.1|WP_053232298.1|2518445_2519672_-|URC4/urg3-family-protein
MSESDIALLRSPSTIRARCRAILDAGVRGELAQLDVRLDRMDAVVARVVRVTRAAYPDLRIPYHSRWGHFRAGKVDRVASFDREIAALDRDEQARVRFELAITSVLLDAGAGTKWRYHEASSARDYDRSEGLAVASFHMFRDGLFSGDRRSMRADAEGLDRVDAATLARGFHVSDANPMVGLDGRASLLARLGAAMRAAPRLFGADHPRLGGLYDHLRAQVDANGELPARLVLAALLEGLAPIWPGRIELGGVNLGDVWRHPHAGGEGLTKGLVPFHKLSQWLAYSLVEPLEHAGIRVTSLDELTGLAEYRNGGLFVDEGVLAPRRAEILTSPHAPGDEVIVEWRALTVALLDETATRVRAAIGKSAAELPLCNVLEGGTWAAGREIAREKREGGGPPIQVVSDGTVF
>NZ_CP011125.1|WP_053232297.1|2517747_2518380_-|uracil-phosphoribosyltransferase
MSPEVHVVSHPLVQHKLSLMRRETTSVSQFRQLLEEISMLLAYELTRDFPLSTERIKTPIAEMDAPVIEGKKLVIISILRAGDGFLTGMLRVIPSARVGHIGLYRDPKTLMAVEYYFKVPGDLADRDVIVVDPMLATGNSAVAAVDRIKSRGPKSIKLMCLLAAPEGIKTLHETHPDVPVWTCAVDEKLNEKGYIVPGLGDAGDRLFGTK
>NZ_CP011125.1|WP_075097875.1|2517321_2517693_+|large-conductance-mechanosensitive-channel-protein-MscL
MLKELRDFLLRGNVLDLAVAFVMGAAFTRVVTAFTEGILMALVAAAVGEPSFDDLAVELNGTPIRYGVFLTALVSLLLVGTALFLVVKGVNALRRPTPAARVETDHDVLVQIRDALRTPTTTA
>NZ_CP011125.1|WP_083457297.1|2514313_2517208_-|excinuclease-ABC-subunit-UvrA
MPPRRASRPSTSTPNHSKRSAAAREPDTIEITGAREHNLQVDHLSIPKNALVVFTGPSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGRLERPAVERLKGLSPTIAIEQKSATNNPRSTVGTITEIQDYLRVLWARAGRQHCVECGKEVRGRSTDEIVRDVLGMREGAKFLVLAPLVTHRKGEFRDLFEGLASRGFARVRVNGEIHRLDAPPTLDKKRKHDIELVVDRLVADAASRSRIAEAVELGLKEGQGELTIEPEGSDKLTFSASRSCCGRTYPELSPQSFSFNSPLGFCSACNGLGTRTEIDADLVVPDRTKSIREGAIAPWATSVERGEGWTFRIIEAMSEATGVDLDVPFGKLPKKLQETVLYGIEGKKIRVTWGQEGSESHGSWGIKFHGVIPTLMRRYRDTTSERMREHYRQYMRDVACDACDGKRLRPESLSVKVGGRGLAEITNSTVRDCARWFEEGITLSSHDARIAEGVLREIRSRLGFLLDVGLEYLTLDRAGPSLSGGEAQRIRLASQLGSELSGVMYVLDEPSIGLHPRDNERLIATLRHLRDLGNSVIVVEHDEDTIRTADHVIDFGPGAGHLGGRVVFEGAPSELATAKGSITADYITGRKKIEVPAKRRKHEHAITVRGAREHNLKNVDVSFPLGCLVAVTGPSGAGKSSLVDGILLPALARALHNATEPVGVHDRIEGLQHVDKVIAIDQRPIGRTPRSNPGTYTKAFDEIRNIFAQQPDSRARGWEAARYSFNVKGGRCESCQGDGVVRVEMHFLSDVYVPCEVCGGRRYDSETLSVKYKGKSIADVLDTSIAECLELFSPYPSLARVLRTLTEVGLGYAKIGQPAPTLSGGEAQRVKLAKELARTQTGRTLYLLDEPTTGLHFEDVRHLLEVLAKLVEAGNTVVVIEHHLDVIKCADWVIDLGPEGGDAGGRVIATGTPEQIAKNKASVTGKWLAPLLK
>NZ_CP011125.1|WP_053232303.1|2527644_2529009_-|sigma-54-dependent-Fis-family-transcriptional-regulator
MSKARVLVVDDDRAVGLVLASLLKQAGYESHHVASGEDALAALASRAIDVVISDVRMPGMDGMELLGEVKQRTPDVPVLLLTAHGSVPLAVEAMKAGAAEFLLKPFDRDEVLFTVEKALATNARVAARPPDAPVRGEGQVLGDSDAMRETIARLKKAAPTVATVLLRGESGTGKEVAARTLHGWSPRHAGPFVAVHCAALPDNLLESELFGYEKGAFTGATQRKPGRVELAQGGTLFLDEIGDISPAVQVKLLRLLQEKEFQRLGGTSAEKVDVRFVAATHRDLEAMVEDGTFREDLFYRLNVVPVWMPPLRERGDDVALLANRFCAELADQNGRAGLRFAADGIAALRAHDWPGNVRELQNLVERLVVFAEGDAIRASDVERELGARSARNGRPSGSPAPIDAGTLDAHRVEAEKGAIRDALARAQGNRTQAARLLGISRRTLYNKLAELGLE
>NZ_CP011125.1|WP_053232304.1|2529075_2530464_-|sigma-54-interacting-transcriptional-regulator
MGWDEDRTDQSSRRAPAARPLVATLVVLHGPRGVAEPRTVVLSPGETTIGRAAAPRTIQLEDARVSRRHALVEVSPRGAVLRDMASSHGTFVGSARIETPRVLADGDVIRTGDSFLLFRVRPLDAPDAPIAGLSGSAPAIAQLRSKIALVAPTDVNVLVIGESGTGKELVAQAIHEMSARRGRFVAVNTSAIPESLAESHLFGHAAGAFTGAKTSHPGYFEQAAGGTLFLDEIGEMPLPLQAKLLRVIEERAVVPVGATQPRAVDVRIVAATHRSLESAVERGTFRGDLFARLSDVLLRTPALRERREDVLPLLARTLGPHAPPLDPDLVEALLLHGWPYNVRELIKIATELRVLGAGSATLDLSMIASRLGRRVDTGPLLAPSAIDEPTQVTAKADTRPPPREPEPEPRDAPSPEVVSALYREHEGNISRIARALGRSRRQVHRYLEAAGLRKKGDPDDET
>NZ_CP011125.1|WP_053232305.1|2530694_2532128_+|serine/threonine-protein-kinase
MLQPGDRVAHYEIVTHLRSGGMAALYLARRVGPAGFARDVAIKLVHPHLAEDESFRRMFVDEARLSARIVHPNVVHVEELGEERGRYFLVMEYVHGASLSQILDRLRRAGRWIEPDVAVRIAIAVAEGLHAAHETRGDDGEPLDLVHRDVSPSNVLVTEQGHVKLIDFGIAKARGRAQETESGVLKGKTRYMSPEQARGERVDRRTDVFALGIVLWEMLAARRFFGERGDVDVLRELIRGPETPRLGELAPGIDPALERVVAKALANDARERYASALELRQALVEAAPRAALVDASGLAETVRVAYDGPIPRPIAPAGVVPAIQVTFAEAPTASSAKRRADAVDAASTPARVAAPRSAMRWVATGAVVVIAAAIAAALGMTSAEPEGVASPAPMVPVPAAAAPPPAAEVAPAPAIEVVPPPVEVRAASTLEVVPATAAPAREVRSAPSSTPRARARAAPRARHELIDGVPIADDGAF
>NZ_CP011125.1|WP_075097877.1|2532172_2533687_+|HAMP-domain-containing-histidine-kinase
MGLEQWVSSAAGALFLALGVLCLVRGARSPLAPPLAFLCITLFVYDVLEVARNFTDDPVWDFLDAGAAALVAPPTLYLVAAFVGKRRALRVPLVVATTYFVGLALVCVSAIVVPSLAWFAGSDAWALAMLGGMLPTFGVVPFLLAQHARRAGPEERARTQLFAVAFVLGVGGVTSDLAAIAGAVAPRVAAVGLLIGVLLLGALALRARVIERITGLAIVNAIALAGLAILGHLIVLEWLGDQTTLMVLGAVAVTLALLAALRPLVSTLTEERERTRHLATMGRLSAQMAHDLKNPLAAIKGAAQFLAEERRQGRSIDEQDAFVSLILEQAERLGRVVDEYQRLGRVEAVLAPVALERLAQEIATAQRAAARGEGIEVACDVRGEVGVTQADQDLLRAALENLVRNAREALVAAGRERGRVTIVVEGGEREIVLRVEDDGPGMDARTRERAFDDFYTTKATGSGLGLAYVARVAQAHGGRARIESEEGIGTSVELALPRVVTAPR
>NZ_CP011125.1|WP_053232307.1|2533670_2534159_-|YfbM-family-protein
MSGRGVLFAVDDDTLARLGDASSDAEVRAIVSELEERWDPATTCELDKAWDAIHRALTDGRLSFGNGAPPLSWTILGGRRLHDGDELIVTVKAPDQVQRIARALGGWDRAKLRAAYYRIPKQDYGDLDEEDLEYVWAYFSKMLELWKDAAREERGVVFSVEP
>NZ_CP011125.1|WP_169791406.1|2534669_2535578_+|APC-family-permease
MRASAVQQALITTVKYAGVLLLAVLGLLAPLVAGAEVPVPADPPAFASAPTAAGVFAALVAAMWAYDGWADLSSLAGETRDPSRTLPRALVLGTLAVGVAYLLANLGYARVLGVEGLRRSTDGSGMAAAHLATLTLGAAGRALLASLVLVSCVGGCMASLLTNSRTFVPMATDGVFVEWLGRVWARTGVPANAIVVGAILGAAYVSSRSFEQLTNAFVVGYFPFYALAVLGLFRMRAKEPDLPRPFRVPLHPLPAIVFLVGAACVMAGAATGLDGSSVIAAVVIAAGVPVSFVWLRAGRPAG
>NZ_CP011125.1|WP_157068935.1|2536000_2536663_-|hypothetical-protein
MPRKLGSDESLDSLEDEILFTRAALEADEDAADLLTRSDDWLSLVDAARARDRSARIAEASASALRAVANGRLDDACADFGRRLALEAPRSSARWTRFFDTAPSAWVARALSRQVASVKAWLTISGDALLDAHRAPLARWSDAAQAALDRTAASAQVRGAARVGREELALDLTRERDGLHAALVARAAERGLPRDWPARFFRIEDRRRRRADEDPAPAPA
>NZ_CP011125.1|WP_053232311.1|2536803_2537121_+|hypothetical-protein
MSEDSARPLAHAGREEQARELFPYREQTPEEYAARHFHEWMCFSFDEFRYSDPELDAWIARLGQIFFERPGAPSVEELRARFLTPEEIEAIHERDQEELRSGTRA
>NZ_CP011125.1|WP_053232312.1|2537499_2538357_-|DUF1963-domain-containing-protein
MRLELPAEIEAVRERIEASIAPCLFLSPAEDGELTRTRLGGAPLLPPGVAWPRSDRGPLSFVGQLDFRELQHAAQKCAAVRELDVALPTDGVLSLFYDVEEQPWGYDPAHASGFALVYAPDPARAVDVEPPEGAIPFDEEPLVAGAGLTLPWPDDRAYASLEITGEAAERTYRDYVERFSLAQGRGIPALRQQVGGHAQWLQRDGRITAELASSGVHAGGDPRTWRSADLRRAESEAQSWRLLWQLKPEDDRFTWVDLGTLYVLIRDEDLRAQRFERAWVVFQSG
>NZ_CP011125.1|WP_053232313.1|2538627_2539779_-|metallophosphoesterase
MRISPRRLIVFLGVVGSVSALLHGYAWLRLFRDPAWGAPWELLGGVALAVLGVLVPAAILSARTVRPSIATPLAWLGYSWLGTIFYLDVLLLPIDLARVLLAAVDPDGAPFLGARWVAATATVGALSLVAAGIARVRRGPVLREVDVPIEGLPAALEGFRIVQLSDVHVGPTIDRAFVERLVARTNALAPDVIAITGDLVDGSVAALARGVAPLSELRARHGVFFVTGNHEYFSGADAWARHVATLGARVLRNEHDVIDHDGAALVVAGIDDVIAPHFGDRSDVELALEGAPEGVPVVLLAHQPRSIDAAARAGVALQLSGHTHGGQMQPFGLLVKLEQPFLSGLHRVARTWLWVSEGTGYWGPPLRVGSRSEISVVRLVAAR

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Crispr_ID: NZ_CP011125_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_11

2999831-2999920

Orphan

Consensus_repeat	Method
TCGGCTGGCGGGCGTCTCGTGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_11

>merge|NZ_CP011125|11|2999831-2999920|CRISPRCasFinder
TCGGCTGGCGGGCGTCTCGTGCGCTGAGGCGGACTCGGCTGGCGGGCGTGTCGGCGCTGAGGCGGACTCGGCTGGCGGGCGTCTCGGGCG

>NZ_CP011125|11|9|2999831-2999920|CRISPRCasFinder
TCGGCTGGCGGGCGTCTCGTGCG	CTGAGGCGGACTCGGCTGGCGGGCGTGTCGGCGCTGAGGCGGAC
TCGGCTGGCGGGCGTCTCGGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053232658.1\|2990532_2992422_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224196
NZ_CP011125.1\|WP_053232657.1\|2988643_2990536_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224196
NZ_CP011125.1\|WP_169791427.1\|2997013_2997832_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367482
NZ_CP011125.1\|WP_053232670.1\|3004746_3005391_-\|ribosome-biogenesis-GTP-binding-protein-YsxC	unknown	unknown	gnl\|CDD\|234770
NZ_CP011125.1\|WP_053232663.1\|2999050_2999731_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176853
NZ_CP011125.1\|WP_083457345.1\|3003525_3004617_-\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|335313
NZ_CP011125.1\|WP_053232654.1\|2985821_2987261_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379142
NZ_CP011125.1\|WP_053232656.1\|2987747_2988647_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP011125.1\|WP_157068993.1\|3002349_3002859_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157068995.1\|3008596_3008989_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232671.1\|3005400_3006954_-\|histidine-ammonia-lyase	unknown	unknown	gnl\|CDD\|236484
NZ_CP011125.1\|WP_157068994.1\|3007066_3008437_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_083457343.1\|2995254_2997003_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366307
NZ_CP011125.1\|WP_053232655.1\|2987345_2987717_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232659.1\|2993437_2995069_-\|D-aminoacylase	unknown	unknown	gnl\|CDD\|238622
NZ_CP011125.1\|WP_053232666.1\|3001291_3002353_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|225070
NZ_CP011125.1\|WP_053232664.1\|3000022_3000799_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133407
NZ_CP011125.1\|WP_053232668.1\|3002864_3003503_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232665.1\|3000864_3001281_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791428.1\|2997892_2998984_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053232658.1\|2990532_2992422_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	1.20898e-07
NZ_CP011125.1\|WP_053232657.1\|2988643_2990536_+\|ABC-transporter-permease	gnl\|CDD\|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	4.11661e-09
NZ_CP011125.1\|WP_169791427.1\|2997013_2997832_-\|hypothetical-protein	gnl\|CDD\|367482	pfam03411, Peptidase_M74, Penicillin-insensitive murein endopeptidase.	1.91728e-16
NZ_CP011125.1\|WP_053232663.1\|2999050_2999731_+\|SRPBCC-family-protein	gnl\|CDD\|176853	cd05018, CoxG, Carbon monoxide dehydrogenase subunit G (CoxG). CoxG has been shown, in Oligotropha carboxidovorans, to anchor the carbon monoxide (CO) dehydrogenase to the cytoplasmic membrane. The gene encoding CoxG is part of the Cox cluster (coxBCMSLDEFGHIK) located on a low-copy-number, circular, megaplasmid pHCG3. This cluster includes genes encoding subunits of CO dehydrogenase and several accessory components involved in the utilization of CO. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	1.6486e-09
NZ_CP011125.1\|WP_083457345.1\|3003525_3004617_-\|dienelactone-hydrolase-family-protein	gnl\|CDD\|335313	pfam03403, PAF-AH_p_II, Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	6.97738e-16
NZ_CP011125.1\|WP_053232654.1\|2985821_2987261_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	2.20302e-14
NZ_CP011125.1\|WP_053232656.1\|2987747_2988647_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.15872e-83
NZ_CP011125.1\|WP_053232670.1\|3004746_3005391_-\|ribosome-biogenesis-GTP-binding-protein-YsxC	gnl\|CDD\|234770	PRK00454, engB, GTP-binding protein YsxC; Reviewed.	9.6866e-77
NZ_CP011125.1\|WP_053232671.1\|3005400_3006954_-\|histidine-ammonia-lyase	gnl\|CDD\|236484	PRK09367, PRK09367, histidine ammonia-lyase; Provisional.	0
NZ_CP011125.1\|WP_083457343.1\|2995254_2997003_+\|hypothetical-protein	gnl\|CDD\|366307	pfam00791, ZU5, ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.	6.4573e-07
NZ_CP011125.1\|WP_053232659.1\|2993437_2995069_-\|D-aminoacylase	gnl\|CDD\|238622	cd01297, D-aminoacylase, D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics.	6.5024e-97
NZ_CP011125.1\|WP_053232666.1\|3001291_3002353_-\|amidohydrolase-family-protein	gnl\|CDD\|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	6.1211e-14
NZ_CP011125.1\|WP_053232664.1\|3000022_3000799_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133407	cd04780, HTH_MerR-like_sg5, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 5), N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	3.70379e-18

>NZ_CP011125.1|WP_053232663.1|2999050_2999731_+|SRPBCC-family-protein
MRLARRAAVIAALACALGVLLPLSTAQTIGAQDRGFSDAERSVLAAGRLIARRRVEQRGNLVHFGGTSFQTVDRPLTEVWRAVRDPANYRNLLPQVESVSVVSRGEHEGVIRIEHAYGLIRAAYHLRLRFADGRHDLTFDLDATRPNDVRSARGFMTLSEWPGDPGRTLVTWGILAAVDEGILGGLVRPQLHAWMLRVPTTMRSYLQGRGRSRFLADSGHASTATH
>NZ_CP011125.1|WP_169791428.1|2997892_2998984_+|hypothetical-protein
MRAHHLALVLILAACGGAPPATSTRTPDAPQPREHRASTVPTSPRTLARDATFADLVAAARTLDDRRDQESDAACLIGVTPSGFELRADLAVAVRPLAEPEGDLDARLANDPGPVRVLTRYGSYGTGAAQMGLVATSTTLPPTRGTALALFVTPEGVYTRRSDQPGGERDASRVAWVVEHTDWSAFDLVVVTAEARVPLTTLVALLEALPASLAGRITLAVPLAAGTRLPDAPPAVDGTAERGQLCPDGLPELTEDAALGDLPASSIRAALAPLQSSAELCVGTSSGPGAAGGRVALAVRIAPDGRVSDACVMEDSTGDAALRACLSRAALELAFDAPSGYVDFALPLVLEPGRAQRQVAVCR
>NZ_CP011125.1|WP_169791427.1|2997013_2997832_-|hypothetical-protein
MRRSAAVLLAIAIALLATVARATPGDHDDPRPRRARRATPSTSVGLPFRGRLRHGVLLRESEHVRYAGEYREGGRFYGTDELVQLIERAAARVSQRLPGARLSVGELSARQGGRVSGHRSHQNGRDVDIAFYMIDRDGRPYDPWGFAAFDRHGNGMPPNEALRFDDARNWELVARLVSDPDARVQYVFVADTLRRRLLATARRRRAPASIVARAEQLLVQPSHGHPHRNHFHVRIYCPPADRPSCEDREPFHAWYPGTPPRTEHASAEDAGD
>NZ_CP011125.1|WP_083457343.1|2995254_2997003_+|hypothetical-protein
MGTTRRIAAAIVLALGSGPSCAPGEPVLASAIVGAEGGRIEGDGIVLEIPAGALEGATRITVSVEDAPSDERYALRSPLYRFEPSGLVFAEPVHVVLEAPAAAPGSVLLWSREGDETSFDFAGFVEDGVAAAAVRHFSYGAIADGSTCSDAPGACTGPTCEAGPAPDAECAGEESAGSCPDACAAGGGDCTGACAGDATCQGNVEPCRRLCVCDGTEPPRGMLCASDPTQSGDRPFDPSECPETNAQIGPVLANGLVERPTDGHEILGLRDGEACTGWALRSIDRHLCSCEYRGRTLCRRPWDDPGGTPSCSTTLDGLVPTDALEEFATRAYTQEEGACSGYYVVGSANSARVEGVLTACDATTTSVGNEWREEAGTTRACQLFGWPGAIPESVEIDRARCRLAEQDWARLQQRREDCGLPPRTLVPNDGHTVAILTTPGEDEITGLNGRTGGAQPYRARAVEEGTCPPPLTRTYGEDATRYRGAGPTHCHAEGDALEQLSVLRMREPGTPGAGDPRQGATGGRTTGSAELIVDRDPCAMSCAPRGVDRMRSIAGLEELIVRSPQGTRRYADGLPETGVPLD
>NZ_CP011125.1|WP_053232659.1|2993437_2995069_-|D-aminoacylase
MRLLLRNATIIDGTGAEAEAGDVLLEDDHIAELGATTLAPDEVIDARGLVVTPGFIDVHSHSDFTLPGDPEARAKVMQGVTSEVVGNCGLGLFPSNETVERFYALLSPMLFGEPGGGCFRDIDAYRARLEERGVSVNVVPLVPHGNVRCQAMGLAERAARPDEIARMRDSVDTNMRQGAFGLSTGLVYAPGAFADTEEIVELAKVSAAHGGIYASHMRDEGSRLVQSVEETLRIGREAKIPVQISHHKAADRWNWGKVETTLAMVDRARAEGLDVHSDVYPYTAGSTVLSAMFLPLWAFEGSQDRLLERLRDPKVREQIVEGSKERMMKLATLPGVLDRIVPKRLILPFVLFELSRLVVVSSLKNQQQYEGMTLREIAKARKQKLYDMLLDLLVEEELAIAAIAHVMSEDDVQRVMAHDATMIGTDGFPQREGKPHPRAFGTYARVIEHYVRERRLFGIETAIHKMTGMVAKKLGLRDRGVLRAGAKADVVVLDAARVKDRATYASPKNHPEGIVHVFVNGVHTVKNGKHTGARGGRVLHRAG
>NZ_CP011125.1|WP_053232658.1|2990532_2992422_+|ABC-transporter-permease-subunit
MIALLRKELRALVPHALLCFLVISGDVISRPLTEQLDIQTWSSISAVDPGEGGGLAFMLALVAFFVAYAAFPREHDDGTIDFLRSLPVTRRAIFSAKMLAGAGVLVLFTALGQVTNWLLQLPNPQSFSGDQFRLDVALGVAALQSTFVLVLYAHGVLASTMRRFGLLPYALVMFVLLAAEEIEPSLAWLNPASICRLAYRGQVLLVPWGDIAVHVPIALVALGISYLVWMGPFEQLRDALAPKRDGRAAIAFGCGTAVVVFVGLAVMTVLAVRSVQENGLPSDEPEGIDWQTAEARTEHYAFVYPTNLRARALRLVGSADDIAESVARVVGAREVPFITVDLAETSAHHEGIAAGTRIRMGLVGQDDDARLRHVLAHESTHVLQGRESDRRLMTQRGTRAFVEGSAEWVAYRVVPNDAAQTESRIVAAAGWTRHRLQLEDVLDDESLRQRFDTSLAYSLGEVLTEGIARACGERAVGDVMRAIGRSDAPQDLEPLALWQDALQSIGCSEVAARAQMERVIDDVARDHADAIAALPRAGAAVTGRDEETTTVVATLDRDAPEGATWTLRVRRDRMVSDTEIRSVRGVVDAARRRVTFLVPRGWSWPRFDLQVCMVPVGGNWSWCEGWTSG
>NZ_CP011125.1|WP_053232657.1|2988643_2990536_+|ABC-transporter-permease
MKRIAALALKDLAEHAVALAMLVLFMGVAWALLSLIVLAQPATVTYLEVHASLMRFFLPVAGLALGNRLVVAEYHGRTQRFLESLPLGRADVILVKLALGVLVIEALALGSLGATLVLAITREAIDARFVAIIAARTATYALFGMCWFTAMGMLGRLRVPLYIAIGVAFALVANGTELEVSRFGPIALVADDFVLERTRWPVEPLLVTLALAAGWALLAIGLATVREGSVAETLAKRMSLREGVTLVIVVIAILIAWMRLSPPNQRPPYEWEDGGVLRAGDAPIEIMYGLEDARPDAEALMARLRRELPPLRDAMGWAQLPTVRVALSERLDGSTFERVTLGEDDGILVRANYRRGPEWDEDALLSELVGLVIDDATGGRALWEPIEWPRDGIAAWWPRRDEPELPETIELRALWATRERGPDASRLRAWDRTIQREGERVAGALAAVGIDVLEEQRGRDAVFALGRALYGHEPPDDFRAVVHGWLHPLSRTLREAAGIDERALIEAWYARLASLRASHRGAWMPRVEARIDVETADGLPTIVARATLDRPPPPGATVSLAHFDDGPFDDFVWPWEPQREERAWPDGERSIEMRLPGRYGPGSRVWVALDLEGTPLGAPMRLAEARVEVP
>NZ_CP011125.1|WP_053232656.1|2987747_2988647_+|ABC-transporter-ATP-binding-protein
MDPDVIEVRGLAKRYGAVEALRGLDLTVRPGDVYGFLGRNGAGKSTTIRILMGITRPSGGSVRMFGEPGGHDLVSWRQRIGYVAQEQSFYGWMTPVSIARFVRAFFPRWDDAEYTRLLRVLDVPSARRIGTFSGGTKVKLALALALAHRPPLLLLDEPTAGLDPVARREFLEIVRHEAEHSGRTTFFSSHLVDEIELVANRVGVVDEGRTRYEGTIDDLVQRVRVVRASELADPAPLHAAIAELQLAVRHEEVREGERRIVVESDDPARFDALAPTIPDAVIELLPLEEVFIAMVRRRA
>NZ_CP011125.1|WP_053232655.1|2987345_2987717_+|hypothetical-protein
MFEFDSGAVRDAAKAYESIQLQPAQEALVKDLGNLVGPKIGLDPFPCRGFWLMAVRAWQVEHATTADSIGAMPPEKRAAAAREIAKHFRDIVGKQLRDPREQSRLDRVLDDAFAHYLARYNKR
>NZ_CP011125.1|WP_053232654.1|2985821_2987261_-|trypsin-like-peptidase-domain-containing-protein
MLDRRIALGAALALAACVPEPSLATEPVVYGEDGRREAYEVDATLRALALGSSAAIFDPENLDVRDPSAIVPSGRRLQSDEDLCDDQRFLDQPTAASCSGTLIDDDLYLTAGHCVETEEECRGLRFVFDYAYASDGVLETIGEDDVYACRRLVAHRDQDAPWRDHSIIQLDRPVVGRTPATLRRGALTPGEPLVLIGYPDTIPMKIDASGHVNDARAEVLDRFYASVDAFGGNSGSGVLDAEGRLVGVLSGGEDDYVRRGDCSVVNVLDDACPGGDCTRHGEYVGYAQNAIDDLCASGWPSARLCDRAATCGDGFCSGTETSETCADDCDAPRCGDDVCDRGESATCEADCGRVVPDAWTCEVRWYAALDDCDCACGAPDPDCESGRLRVVNCERGETCVEGVCAPAPDAGTTPRDAGGAARDDASISTDAATTRDAGPVIVPARDEGCACGVAPRRAPSAALVALLALVALAIRARRS
>NZ_CP011125.1|WP_053232664.1|3000022_3000799_-|MerR-family-transcriptional-regulator
MDEESELEGGRSVKVSALAKMSGVPAATIKHYVREGLLPEPSRTSKNMAYYDVSLVPRIKKIKELQRTRFLPLKVIKSILDESELESEDETVGATIARVLEQTAPTERRTREELIASGMPEEQLVWLRGAGLITPQPDSKREVYAGDDLELLRVLGASRKAGITAEMLPVTILGEYAQALRTLVEIEVRMFREGVMPRAGDDLPALTEAATTLSERLVIVLRRRMLVPTMRALAEQAKRSRSAPPPAPKKRTPRRKAE
>NZ_CP011125.1|WP_053232665.1|3000864_3001281_-|hypothetical-protein
MTTRTMLALVFVLSACDERATTTADAGDDARASSTRGTIAGTITYDGSGAGRLTVGVWPQTPPAGPPSEIFVRDDPTFPIDYELRGLAAGTYYLGVVLDIGANHPTIPGAEDPRSFPTDGIVVEGDTHDVDVELVDPE
>NZ_CP011125.1|WP_053232666.1|3001291_3002353_-|amidohydrolase-family-protein
MTRIVLFVAVVAIASDARADIEIDGERVEVVDMHLHPGHYANMAIEGRRFIGASLPPFARLYAPALIEVLLDPYAEHVGIRAETEMAGVDHAVLFAVYASRSTGFYTNDELERVLADERNAGWAWGMASIDYEGFLDDGIAQQRLDALASYFEQRRDLFVGIKLAHAHQAVTFDDARYLGVYDVAARFGVPVLLHTGLSPFPGTQTDPAYYDPEGLEAVVTAYDGAHGAPRVDFVLSHVGQGDPRAVEHALALAEAHENVWLEISALNRPFLLDDDGEPIASTEPQYPSVLRRILERGLVERTLFATDGPQFSGMVRSYVQRIALGMREAGYSLDQIRRVMSGTFYRLYLQSE
>NZ_CP011125.1|WP_157068993.1|3002349_3002859_-|hypothetical-protein
MRASITIALVLVACEAEVAPALDAGLEVRPGEGIGPVHVGMRYADVREALGPLEGAFTSERVAFGRYTSLGLEVVLVSSEDASVSDDAIVIGVGALQSEGFVGPVVPGMRRDALVAAYGEPDDEAGETALYREGFGVEHDGDVVSKVGVFRPYTHEPTPPAMARATGTR
>NZ_CP011125.1|WP_053232668.1|3002864_3003503_-|hypothetical-protein
MEKVALAWLCSLALVACGGDDDGDGTAGFDAGRSGIDAQVAPGVDSGTQPDAYVAPGTDAGGADAYVPPGTDAGGGGGDERDPRLETDPDPGQVGCGSMTCNVPAQTCCTQLSGQTCVAPSSCSGGLAAPGNCDGPEDCSDGQLCCAPSGFADLTTGTTCAASCGSRHAMCQTDADCSGGATCHTCRPPGGMGGVVGLCNTGASCPGSYTSL
>NZ_CP011125.1|WP_083457345.1|3003525_3004617_-|dienelactone-hydrolase-family-protein
MPRSLPALLLVVAVACAPEDDACAAAPFASPGPFVAGVTTLDVDGLAVEVWYPAESEAGTPRDVYDLRDHLPSELAPAIPDDAPTTFTTPAHRDVPVASGPFPVVYFSHGLGGYRRQSSAITAHLASWGFVVAAPEHAERNLATVLRVAMGTEGASISDDAYAQILAAHAHLASEARFAGALDLSRVAVMGHSAGGGAVQALVDRSPLEADAWIGMATVAAPQASTVPGLLLGGSLDQLATVASMDELFDHEIVASPARLVRIEGAGHLAFSDICVIGRERGGVLAIAQDAGLEIDELVVTLATDGCQPQALPAEDAWPIVGHYAVAHLRDALGVSTPATPITGLEPDAATCFGARIGRNDAR
>NZ_CP011125.1|WP_053232670.1|3004746_3005391_-|ribosome-biogenesis-GTP-binding-protein-YsxC
MQVDIRDARFVASAMRQDQLPPPAFAEIAFAGRSNVGKSSLINQLVVRRKLVRTSSTPGATRGLLLFRTALAIQRAGKEPQLATLDLVDLPGYGFAKRSKIERRSWGPMIEGYLENRVGLRAVVVIVDVRRGLEDDDRQLLEFLDHIRRPAVLVATKLDKLPASQRMLEVAKIKASAGRPVVGVSSETGDGRDRLWSRLIAAAGIAPADVTPSS
>NZ_CP011125.1|WP_053232671.1|3005400_3006954_-|histidine-ammonia-lyase
MTRPQVRLGDAISLETLDLVARGDATVVLTDEVRARIDRARAAVDRLADGGDRAPNVYGVNTGFGALAETRIAHDQIRALQRNLVRSHACGVGPLLPREAVRAMMFLRAQTIAMGNSGARAKIVDLVIAMLERGVHPCIPSQGSVGASGDLAPLAHLALVLIGEGEAEHQGAIMPGHEALAAAGLTPVELEAKEGLAMINGTQLITAIGALAVLRGERLCTNADVVGAMSLEALKGTGRPFDPRVQQVRPHPGQATTAANLRALLEGSAIMESHRDCGKVQDPYSLRCMPQIHGATRDALAWARQVIEREIVASVDNPLVFVDERGEADFVSGGNFHGQPLAIALDTAAIAIAELANCAERRLEQLVNPAMSSGLPPFLAPRSGLDSGFMMAQVTAAALVSENKVLCHPSSVDSIPSSAGKEDHVSMGSISARKCMQVAEHVRTVLAIEAMVAAQGLDLRLPLEPGVGVRAAHVALREHVPTLVEDRVLHPDILRCCELVDRGVLVTAAERVVGRLS
>NZ_CP011125.1|WP_157068994.1|3007066_3008437_+|hypothetical-protein
MALASVLFAAGPALLVPTRAMADDDELVLMREPAAFVDVIDAFDDHDPFDLDISIGYVRTWELGRIQREPGMGDPEDRRSREWLDVADYSREVNQLVFGLDVGIFRDLALYGRLPLILSDDRSLSRIGNDDPSSVLLDRSSAPMPLFDVPAGEGFRSPTRSGLDWVSVGLAWSILNQQRDPHVPTWLIMLEGRFNIDEPMRACRRAGGDVVCQGGGSEPGISRGTNALRFETRGSWRDRYVEPYAGLAFQIEFPGNAADLFTQGGNLAGYINQRPPIQGRLTAGVAIIPWEDRQHWQRFSIDLRFTGDYVSEGRDYSPLFDALGSSTNPYLTSPACEGVTGGATCQAAGYEQVDFTGLTDTQAHARLGGQITLELQAARYVRFGITTAIFHSPSYGLTQADACNPNASSDDPGRRGTCRSGIINPHHRAVIDLPGQRFRIESLTQIDVAANVTAQF
>NZ_CP011125.1|WP_157068995.1|3008596_3008989_+|hypothetical-protein
MSRVGIVLALIGAFSCAACDSEAENAFERRMDERRARLQQRYEAREQQVAEDSEVQIGEIDQRIEQLRARREAELEEELARERVRMEDTIERRRDQRLEALSQERDQRLDQLTEDRQRGEDRIEEGLSPE

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Crispr_ID: NZ_CP011125_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_12

3103688-3103808

Orphan

Consensus_repeat	Method
CGGCGGACGCGTCGCGTCGATGGGCACGCACAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_12

>merge|NZ_CP011125|12|3103688-3103808|CRISPRCasFinder
CGGCGGACGCGTCGCGTCGATGGGCACGCACATCGTCGTGGTGTTCCTTCTCCTCCTGCCCTCCTCAGAAATTCTCGTCGTGCGAGCTCGGCGGACGCGTCGCGTCGACGGGCACGCACAT

>NZ_CP011125|12|10|3103688-3103808|CRISPRCasFinder
CGGCGGACGCGTCGCGTCGATGGGCACGCACAT	CGTCGTGGTGTTCCTTCTCCTCCTGCCCTCCTCAGAAATTCTCGTCGTGCGAGCT
CGGCGGACGCGTCGCGTCGACGGGCACGCACAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053232757.1\|3107774_3108761_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|183621
NZ_CP011125.1\|WP_169791434.1\|3097118_3098375_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP011125.1\|WP_157069004.1\|3103999_3104806_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP011125.1\|WP_053232747.1\|3095059_3095470_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232753.1\|3101923_3103516_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP011125.1\|WP_053232762.1\|3111737_3112874_-\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|334855
NZ_CP011125.1\|WP_053232750.1\|3098696_3099365_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232752.1\|3100802_3101927_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|180607
NZ_CP011125.1\|WP_157069006.1\|3113028_3115641_+\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|381604
NZ_CP011125.1\|WP_053232760.1\|3109880_3111593_+\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NZ_CP011125.1\|WP_053232745.1\|3092713_3094312_+\|GMC-family-oxidoreductase	unknown	unknown	gnl\|CDD\|225186
NZ_CP011125.1\|WP_053232746.1\|3094308_3095052_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791433.1\|3095521_3096094_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232758.1\|3108836_3109079_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl\|CDD\|376904
NZ_CP011125.1\|WP_053238789.1\|3096201_3096960_+\|DUF1295-domain-containing-protein	unknown	unknown	gnl\|CDD\|178015
NZ_CP011125.1\|WP_053232751.1\|3099445_3100744_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|181000
NZ_CP011125.1\|WP_083458501.1\|3106711_3107713_-\|DUF1517-domain-containing-protein	unknown	unknown	gnl\|CDD\|369378
NZ_CP011125.1\|WP_053232759.1\|3109081_3109774_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053232761.1\|3111598_3111847_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232755.1\|3104805_3106689_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|338048

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053232757.1\|3107774_3108761_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|183621	PRK12607, PRK12607, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	2.24019e-168
NZ_CP011125.1\|WP_053238789.1\|3096201_3096960_+\|DUF1295-domain-containing-protein	gnl\|CDD\|178015	PLN02392, PLN02392, probable steroid reductase DET2.	4.13821e-76
NZ_CP011125.1\|WP_053232758.1\|3108836_3109079_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl\|CDD\|376904	pfam02700, PurS, Phosphoribosylformylglycinamidine (FGAM) synthase. This family forms a component of the de novo purine biosynthesis pathway.	1.27788e-35
NZ_CP011125.1\|WP_053232753.1\|3101923_3103516_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.15177e-12
NZ_CP011125.1\|WP_053232762.1\|3111737_3112874_-\|dienelactone-hydrolase-family-protein	gnl\|CDD\|334855	pfam02230, Abhydrolase_2, Phospholipase/Carboxylesterase. This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.	1.63027e-15
NZ_CP011125.1\|WP_053232752.1\|3100802_3101927_-\|ATP-binding-protein	gnl\|CDD\|180607	PRK06526, PRK06526, transposase; Provisional.	9.05477e-51
NZ_CP011125.1\|WP_157069006.1\|3113028_3115641_+\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|381604	cd13401, Slt70-like, 70kDa soluble lytic transglycosylase (Slt70) and similar proteins. Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.	1.14284e-57
NZ_CP011125.1\|WP_053232760.1\|3109880_3111593_+\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NZ_CP011125.1\|WP_053232745.1\|3092713_3094312_+\|GMC-family-oxidoreductase	gnl\|CDD\|225186	COG2303, BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism].	3.73298e-25
NZ_CP011125.1\|WP_169791434.1\|3097118_3098375_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	3.29133e-20
NZ_CP011125.1\|WP_053232751.1\|3099445_3100744_+\|adenylosuccinate-lyase	gnl\|CDD\|181000	PRK07492, PRK07492, adenylosuccinate lyase; Provisional.	0
NZ_CP011125.1\|WP_083458501.1\|3106711_3107713_-\|DUF1517-domain-containing-protein	gnl\|CDD\|369378	pfam07466, DUF1517, Protein of unknown function (DUF1517). This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.	2.55951e-35
NZ_CP011125.1\|WP_053232759.1\|3109081_3109774_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.20535e-21
NZ_CP011125.1\|WP_157069004.1\|3103999_3104806_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	6.57997e-06
NZ_CP011125.1\|WP_053232755.1\|3104805_3106689_+\|hypothetical-protein	gnl\|CDD\|338048	pfam11617, Cu-binding_MopE, Putative metal-binding motif. The seqeunce of structure 2vov is not matched in any other sequence either in UniProt or in NCBI (Sep2014). The model is of a short repeat not found on the G1UBC6 - 2vov - protein. The presence of conserved cysteine residues and the lack of hydrophobic residues suggests that this repeat might be a metal-binding site, perhaps for zinc or calcium ions.	1.57497e-05

>NZ_CP011125.1|WP_053232753.1|3101923_3103516_-|IS21-family-transposase
MTLLAMAMGAMLFGTVAVSGRDGRGAEDMLPLLKRHEIQVLLSVAIPLDAIAERTGVSVATIKRIRDEAPVEHVDDRAEHRKRGIGRPSKAAPFADDVRAWLEEEPDLPTQELLRRALEKGYGGGKSAFYSLVASARPARTAPVVRFEGLPGESSQHDFGHVDVRFVDGTKKRVHFFASRLKYSRFVAVTLVPNERVETLVRTLVKHFREFGGVPLLAVFDRPRTIVTKSGPGREVEQFNTTFAEVMLELGVGAEMCAPRSGNQKGSVEQLVKWVKSSFFKWRMFADERDLEAQLAAWVRQVNFETPNRATAEIPEARRQQELPRLRPVRLTPETLAMRVPVFVGPTAEVMFEGRAYSMPPQAANVPGTAFVYEDRLRIVAGRHEVEHARGKPGDPPASLPEHRADKLAAVHGARARLYEKREQLLRLGPDALALLTALTHRAPTRSAEHVERLYALYEEHDDDAMRAAISRAVARGTLTISAVGEALSSSDRAKDERELDRTREAQPRAPRAHVAKKRTPRAERKRGAR
>NZ_CP011125.1|WP_053232752.1|3100802_3101927_-|ATP-binding-protein
MSSDLDPLLKRLSLANTRRVWRDLVRRAETEEWSYEQLLQTIFSEEIAHRRGTRLMRAVRAAELPFLRTVEEFDFSYQSTLRLTTIGSLLSPDFVTEGNSVILFGKTGRGKTHLAISLAYRAMQNGFDALFANCAELIDDLSCASREGRLREALARYVKPHVLVVDEVGYLAYGDDAANVLFHVVNERHIKKRAMVFTTNKHPKRWGPVLHDDDLAEAIVDRILDRGRLLKLDGPSIRTKHLAEDNALDDDQDETEALRVSGKPGSQFPEPAPARSAFPSSRIALPFPRAARTRAERDATRERPGRGEARTGREPSHPNPARRQNRGTGRGVEGPTPSCDGGRRGRPETDRSIAAEREARAAMRPPRPDARALS
>NZ_CP011125.1|WP_053232751.1|3099445_3100744_+|adenylosuccinate-lyase
MIPRYTPADFEQLWSPRRKYLAWLDVELAACEAMERAGIVPAGTAAQVRPVADRIDPDRIDAIELETRHDVIAFLTHVEELAGPPARWLHRGMTSSDVLDSSFALLLVEATDKLIARTDALLDAFRARVQEQRKTPMIGRSHGIHAEPTTFGVALAGHYAELARGRARLVAARSEIAFGKIAGAVGTYAHLTPAIEADALGKLGLTPETVATQIVPRDRHAVLASAMAVVAASVERFATNVRHWQRTEVLEAEEPFAKGQKGSSAMPHKRNPILSENLCGLARVVRAAVVPALENVALWHERDISHSSVERMMMPDATATLAFMLDRTKRLIEGLVVYPENLKRNLEKTNGLWASEGVLLELVHKGLARQAAYVLVQRNAMRAFAGEAPFVTLLEADADIRAHLSAEEIRAQFDLGHALAHCDVIIDRALAS
>NZ_CP011125.1|WP_053232750.1|3098696_3099365_-|hypothetical-protein
MSQLEHAARLREFDAPAEITAWAAKQPSFDEAWDASPSSRHRVWLGAVSGVAVETIAESAAAAFFAVVESAPETQTFEHAVEESVAASDAETAAKLAERCERAAHALGSYRERDRTREAIIARAAAHVCRAFEALRAAESSMESDRLLRARTTASYMGGGVHAFLPAHPGPATLLVTAPSSVERGLLVDAVTSAGDAIALLATLVLDTAALDEAVWDALAPS
>NZ_CP011125.1|WP_169791434.1|3097118_3098375_+|M23-family-metallopeptidase
MRRTTAILVLALSILLLAPGRPWRARRRAGVRPNHILTERVLPADWPSEPRTPARIDHARFARALHELCGFMPPGRDERWATWITQYAQEFDVDPFLIGALVHRQSRCLPDAENVEGPGLGLTQIHREMYAEQLRDGVLRYRVIENDRWVERERRVDRFPFAGPRLLMAEPNIYFAAAILAMWKDQHETLDGEFDQQAHRHWVSHFLWGDAVRSDWEEERVFADRRRLLEYYGAHQGMAPLRVRGVEMGCPLDGCPRVVLSWLGAEREGGAREHRGIDVDSLPGEPVRAIADGLVTFAGVDLPGHRSHVQVARAEEYERYGRRDLGAGGRYVCIRHGRGEGDDASLRSCSMHLETVEVRYGDRVTRGQRIGTVGRTGMQRSAAHLHLEMYTGERLEDASELLSGLLLGRPPEDPRARR
>NZ_CP011125.1|WP_053238789.1|3096201_3096960_+|DUF1295-domain-containing-protein
MAEAELHSIATWTEIGLAALTFVSLFFVTAPYGRHGRKGWGPEISQRLGWVLMELPACVLWLGIYFAGTHALELAPLALMALWQLHYVNRTFVFPFRIKAEGKTTPVSIVATAIVFNTLNAYVNARWVSELGSYPISWLYDARFVIGAVLFVAGFAINQHADQVLMNLRKPGETGYKIPHGGLYRFISCPNYFGEILEWTGWAIATWSLAGLAFALYTIANLAPRALKHHEWYRQKFADYPTSRRALIPFVV
>NZ_CP011125.1|WP_169791433.1|3095521_3096094_-|hypothetical-protein
MARRLALSLSLVLVLAVAIPHRAQTQDTPPPQRTEAELRTLLDGAWFLSTPERTGQQRIDAAIERAVGEMNFFLQGVTRDQLREKTPLNRRIDLDFLADGRISCVFDSRFTYTTRPGVAQPFTLPDGAAVDVTQHFRDGRLEQYFGHSLGRRWNHYAVSPDGRTMTVTATQQGPMMPVPVHFTLEYQKRS
>NZ_CP011125.1|WP_053232747.1|3095059_3095470_-|hypothetical-protein
MQTTAVEGAPEIVLEAVSDVLWSTAAAGAIFCLVVPVVAATAALRLHARTSVHLVASAGVAIASVGTGVLLLHQVSGVIHGVEVLVSTAPDRRALAFAEEVRPTSSLPLLTLWAAALVAVLAAVAVARRAPSTAGA
>NZ_CP011125.1|WP_053232746.1|3094308_3095052_+|hypothetical-protein
MSAIRHAIGGACVALMSLAQAGCYGNEATVFPAGAEPWEENLAAMPPADEGTPCAEELTFHRTGWLSARSVHARACIHQPLDVVWRAIRNPQTGRDPTTTARWRVLEWDVARDEDPAPDFSYRTYLFVDDIIDLEMEQVWRHYLVQSETDDTGAETPTLVATRWQKVWGTSAISVMEGSLVARPFEEDPSMTLVEYQYHLDAVARDDHATIETFLGVIYGRLKQDAHGEALDPSDCDECPEPPDSYL
>NZ_CP011125.1|WP_053232745.1|3092713_3094312_+|GMC-family-oxidoreductase
MQQRRRLFLPLSRRTFVKLAAASAASAAFVGCGPSGAEAEEVDNLIIGSGFGGSISAYRLAQAGHSSVVLERGRRWTVQNPGDDVFSDMGFTEGDRYDHRCRWLGTTAPLPGLPPLRPLVPYTGVLERIPGDGIDIVCAAGVGGGSLVYSGMMVRPRDDHFESVFPSEITARSMDPYYERVRELVQPSSLPDDLLELEPWAASRTFIEQGMRAGYDVQRLLCGFDWDKARAEARGELPPQLIRGSYIFGLNNGAKATLDKLYLGMAEATGLVDVRPLHWAQRIIRDGARWRVEVDVIDEMGVVQESIAFSARRLFVCAGTANTNALLVRARDEDTIPDLPDSLGEGFGNNGQHIRARRGVGVDTGAFQAGPACIMLFDQDAPIAMENGPAPLGSEMQMLIGTGQGIPSGRGRFIWNAADGRVVPVWDPAFDAEARANTDEVIRRLNEMNAGEDATARMNLDQSVTFHPLGGCVLGQTTDLYGRVNNQDGLYVVDGALIPGVTPLSNPFWTVSANAERCIERIIAEDYAEATT
>NZ_CP011125.1|WP_157069004.1|3103999_3104806_+|hypothetical-protein
MHRFARRFAVLALSCSVITAVLADASSADAQRRRRPSGRARDAQTQAQEQQREGVDPRLDEEARQLFLAGQTAYDAGRYEAALDYFTRAHALSGRPGLLFNIASASERLRRDDEALRAYEDYLRAMPDAPNREFAQQRIAFLREQIAADARLREAAQRAQGSDVRIDAREEDDAAAPSGAPRVRAAEPRPVGEPTIAPGALAIEEQRDDRDGGDITDEWWFWTLVGVAVVGTGVGVGAAIAAATDGGSGPPVEGDFGPGGVIVALEAF
>NZ_CP011125.1|WP_053232755.1|3104805_3106689_+|hypothetical-protein
MRARLALLCAAIALVACTSEDDDATRVVVTIDADETMRAQVASLRLRVDPDSQGGEATFDQTLAARSFDWPARTTVVPREGDASRTYLVEAIALDPSGAPLVIARAISGFVPGETRELRIELTAACLGVECAAEATCAAGQCVDARIAAASLPRFGQTGMDAGVDDAGTDPDGGVDACTPAATYADEDGDGFGDPATLETSCTVPDGRVTRAGDCDDTCDTCRPEGVEVCDGERDEDCDGTADEGCACTTGASRACPGASDVGECVAGTQRCVEGTWSVCGDRVDPLPETCDGGDEDCDGRVDEGLQRACEGACGTGTETCRAGEWQGCTVRAPRAETCNGMDDDCDGSTDEGVQSTFYRDADADTYGAATQTALGCRAPAGYVTRAGDCDDTCRTCRPGGRETCDGRLDEDCNGTVDQGCACTAGATRACPGGVDTGECSAGTQTCTGGTWGTCTGAVEPAAETCNARDDDCDARVDEGVQRACGPMTEVGVCRRGTQACSAGAWGTCSGAVSAGTESCNALDDDCDGTTDEGVRTTFYADADDDGYGVTSSAIQACMRPSGYATQGGDCDDARDDVRPGATETCDGIDQDCDERVDDGITCMPDAGARDAGTSTGVMDAGVPDDE
>NZ_CP011125.1|WP_083458501.1|3106711_3107713_-|DUF1517-domain-containing-protein
MRGITTRSWALWLAALIAAFALLFWPESALAQGTGGSFGGGNWGGGGSGGGGGGGSSSDDDGGGAAYLVFMLIRVLLVTVGPIPTLIIVVLAGGAWLLVRGSRRSAGDAGMPFGRPPAAGSPLWNQVDITAVRIAIDWRARAFVRKRYLELAKGADARKKPGLVKHVAAIAQALDEARVAWLRAEVSNFHPMSPPDAEHHFRSLADGARAAITSDASGIADPSAHPAEGAVVITVIVAASRELVDVQANDANDLAIALRGLRSVQPHEMIAGDLVWSPPAEGAKMSTRELEARHPAMVVIAEHSIGGRVICHACRAPFPRGIPKCPGCGADVR
>NZ_CP011125.1|WP_053232757.1|3107774_3108761_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MPIDTDTLRKGLELTLDATDLGGPPPRGLGTKYEGKVRDNYLPGDGRRILVTTDRISAFDRVLGTLPFKGQVLNQLAAWWFDQTKDVASNHVLSIPDPNVTIGIDCRPLEVELVVRAYLTGVTSTSIWTHYAKGARTFCGHALPDGLAKNDALPAPILTPSTKAEKGGHDVSVSRDELLAMGRVSAEEFDRASQLALALFRRGQELCAKRGLILVDTKYEMGVDPSGRIVVIDEMHTPDSSRYWFRESYEERRARGEEPESFDKEYVRRWLAAQGWTGDGPMPPIPDEVRIEASRRYVEACETIMGRAFVPDLEDPQVRLRRNLGLTR
>NZ_CP011125.1|WP_053232758.1|3108836_3109079_+|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MKAKIYVTLKREVLDPQGDAVRRALGSMGFEGVRDVRIGKLVEMQIDRTDRAGVEADVKSMGEKLLANPVIEDFRFEIVD
>NZ_CP011125.1|WP_053232759.1|3109081_3109774_-|protein-kinase
MRHARRGDRDRSSRARGRRREQTVALPAHLELPSRDLEYVLRAEIRVPEALRDRALDLRIVRLPARVRVEGDGEPLDDIAPPLLDGYRVETPRAFSETSIERVHALVGDREESSAPTSDEGPPLTETGLLPGTPLYIAPELARGPDALRPASDLFAFGVLAYELLIGRKPYDQPVALAVLEERRPPPRLPLAPHWPSGDPAIVTILEACLALDPAERPSARDVADALEIA
>NZ_CP011125.1|WP_053232760.1|3109880_3111593_+|proline--tRNA-ligase
MRYSQAFIPTLKEVPKEATTPSHVLLLRGGFVRMVGAGIYEMLPLGLRVMTKIAAIVREEMDRAGAQEVLMPALLPKEYFEESGRWESFGDTLLRLKDRKAGEYHLGPTHEEIITDMVRRDVKSYRQLPLNLYQIQMKFRDEARPRAGLLRCREFMMKDAYSFDTSEQNAIASYEAMREAYHRIFRRLGLDYRIVAADSGAMGGSTSAEFQVLAQNGEDAIVACTKCDYAANVEVAAQVVPAKKTDAVSAPSKVATPGKKTIEDVAKFLGLPASRTMKTLMVVADGKLTMVLVRGDHEGNDVKIARAAGAREVRMASDVEIREGVGPVGYLGPVGWSGPVIADMSLDTGEGFVSGGNEVDVHLRDVVLGRDFQAKLADVRTVGNGDPCPRCGGELKSYRGIEGGHIFVLGTHYSAKMRATFLDENNVEKPIVMGCYGIGVSRLVATSIEQHHDENGIKWPIAIAPYHVVVTTAGKGDDLDQAAVRIYDELRAKGVEVLFDDRDERPGVKFKDADLIGIPLRVVIGKKGLAEGKAEVKSREEKDPTMVPLAEVAASIEQRIVAGGGRLRAS
>NZ_CP011125.1|WP_053232761.1|3111598_3111847_+|hypothetical-protein
MAARKHDVAPTSAELQRGSPLAVTIGLLIGFLVLAIVGVVTVVVPEVTDDGDEETQDAEGDRPADAPESDAPASPPAAAAAP
>NZ_CP011125.1|WP_053232762.1|3111737_3112874_-|dienelactone-hydrolase-family-protein
MRRRLCCSDFVALLITLASLSACGASPPRATQARQERTPPVAAWPPPSDPPVPTVPPVAEQEAPLPEPAVAASVPEPSVPLPPPTPREHYQARAPGVRVREGESQGIGFLEIVLGDADPHDPLPMIVVLHGRGDRPRVPGGPFEGLTHPVRVIMPRGPMIVGEGFGWLPVRVLEGRTELLAAGLRDVSTRLSRLIEEVRASRPTIGPTMVSGFSQGGMLAVTLAVRYPTLVGVAFPLAGWLPPPLWPEARPPTGAAPIRAMHALDDERIPFEPTRDSYERLRTLGWDLQLSTYDGAGHAMSAEMDATFHAWLERALTAIARGESRLVEPLPAPEVIEEEPPRVRARRPRREARPERRSRARRPGDRPRRPASPRRRRP
>NZ_CP011125.1|WP_157069006.1|3113028_3115641_+|transglycosylase-SLT-domain-containing-protein
MRGNSAWCCLLSLASILVIAGGATPASAWDGPMCASDGVSMWGVSTAGDATWSEAGVAPSSRFSDASLTSGPREGEPAVLACLPSAPAYTGAPAYIGPSSPTSAAPTLDARFEAARRAYASLAAHRAASRDADALISLATLRELVPELSDRWDLIEGEMRPADRRGCEAYERAAASPHSAVAARGRVGRVRCLLEVRDRRADVELRALLARYPELPEALDLRLLEAEVREERGDVRGAIAILRDIDLTSPDVPAAERARASVARLEAAGHRVPPFTPLQIVERLDRIVRRGAPDFARAEIERVQSMRLPRRELAEVTLLAARIARVEGRFEDAAQLMHQARGATDDADIRAQAEDLAAAAVARAEDDARAELARFTGRARTLRTVNTTRLFGYLRTAARAGLRPEVDAALDELATRSLPCGLRLEAGVLASGAGDDERVARVLEQCVSAPGSIGVASRYHRARALERLGRHDDARAELSQVITQDRTETRWYALWARQWLGGEQVASATTTSALEPGKAREHDGGAPAPTLVVDAPSPRTTVVAPQPAPSPTSEDASEEELDAPIDAPAPRFRPMPRDEIEQRLAAIAETHRVGYPWLTRALAMLRLGDDAGVTDELHEAFLAWYQARGRSALRAGVEAVYRGATPPRMRAESGEVLRARRQLGVADAGVLGDIAASLGDFGLAIRFGGRSRAAMRPRAYEQIVNEVARERGLDPNLLLAVMRVESVYNPRIVSYAGAVGLLQIMPRTGRLIARSMGREAEFGVDDLLDPRTNIEFAAWYLSSLIRRFEGRVPLAIASYNGGPHNVRRWLRDHSEDMPIDAFCERIPFDQTHRYVRRVLGHWAAYRAQQGLPMVELDPSIPELEADRVAF

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Crispr_ID: NZ_CP011125_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_13

3166406-3166530

Orphan

Consensus_repeat	Method
GGAGTGCTCGTTCGCCGGTCCCGGACGGAAGCGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_13

>merge|NZ_CP011125|13|3166406-3166530|CRISPRCasFinder
GGAGTGCTCGTTCGCCGGTCCCGGACGGAAGCGCGCGACGCGCGCGTACGGTAGGGACCGGCGGGCGAGCCGATGTTCGAGTCCTCGCTGGAGTGCTCGTTCGCCGGTCCCGGACGGGAGCGCGC

>NZ_CP011125|13|11|3166406-3166530|CRISPRCasFinder
GGAGTGCTCGTTCGCCGGTCCCGGACGGAAGCGCGC	GACGCGCGCGTACGGTAGGGACCGGCGGGCGAGCCGATGTTCGAGTCCTCGCT
GGAGTGCTCGTTCGCCGGTCCCGGACGGGAGCGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053232813.1\|3158033_3158747_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232832.1\|3166651_3169588_-\|2-oxoglutarate-dehydrogenase-E1-component	unknown	unknown	gnl\|CDD\|236499
NZ_CP011125.1\|WP_053232827.1\|3164987_3165713_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	unknown
NZ_CP011125.1\|WP_083457355.1\|3161285_3162110_-\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234971
NZ_CP011125.1\|WP_169791435.1\|3172784_3174278_-\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP011125.1\|WP_053232829.1\|3165979_3166396_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107221
NZ_CP011125.1\|WP_053232833.1\|3170050_3171748_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173843
NZ_CP011125.1\|WP_053232822.1\|3161997_3163263_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NZ_CP011125.1\|WP_053232843.1\|3176184_3177288_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277343
NZ_CP011125.1\|WP_053232846.1\|3179655_3181776_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379980
NZ_CP011125.1\|WP_053232824.1\|3163361_3164033_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232825.1\|3164029_3164959_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224196
NZ_CP011125.1\|WP_053232844.1\|3177549_3179634_+\|IPT/TIG-domain-containing-protein	unknown	unknown	gnl\|CDD\|366832
NZ_CP011125.1\|WP_053232839.1\|3174361_3175315_-\|YegS/Rv2252/BmrU-family-lipid-kinase	unknown	unknown	gnl\|CDD\|224513
NZ_CP011125.1\|WP_053232835.1\|3171802_3172432_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232847.1\|3181918_3183067_+\|DUF1517-domain-containing-protein	unknown	unknown	gnl\|CDD\|369378
NZ_CP011125.1\|WP_053232818.1\|3160475_3160724_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232841.1\|3175337_3176195_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232820.1\|3160836_3161280_+\|helix-hairpin-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224472
NZ_CP011125.1\|WP_053232815.1\|3158739_3160230_-\|leucyl-aminopeptidase	unknown	unknown	gnl\|CDD\|234863

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053232832.1\|3166651_3169588_-\|2-oxoglutarate-dehydrogenase-E1-component	gnl\|CDD\|236499	PRK09404, sucA, 2-oxoglutarate dehydrogenase E1 component; Reviewed.	0
NZ_CP011125.1\|WP_053232846.1\|3179655_3181776_+\|hypothetical-protein	gnl\|CDD\|379980	pfam17517, IgGFc_binding, IgGFc binding protein. This domain is found at the N terminal of human IgGFc-binding protein and has been shown to confer IgG Fc binding activity. It may play a role in immune protection and inflammation in the intestines of primates.	5.03538e-39
NZ_CP011125.1\|WP_053232820.1\|3160836_3161280_+\|helix-hairpin-helix-domain-containing-protein	gnl\|CDD\|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	6.40647e-21
NZ_CP011125.1\|WP_169791435.1\|3172784_3174278_-\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	1.36604e-85
NZ_CP011125.1\|WP_053232829.1\|3165979_3166396_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107221	cd06464, ACD_sHsps-like, Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.	1.12103e-30
NZ_CP011125.1\|WP_053232833.1\|3170050_3171748_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173843	cd01154, AidB, Proteins involved in DNA damage response, similar to the AidB gene product. AidB is one of several genes involved in the SOS adaptive response to DNA alkylation damage, whose expression is activated by the Ada protein. Its function has not been entirely elucidated; however, it is similar in sequence and function to acyl-CoA dehydrogenases. It has been proposed that aidB directly destroys DNA alkylating agents such as nitrosoguanidines (nitrosated amides) or their reaction intermediates.	6.96928e-127
NZ_CP011125.1\|WP_053232822.1\|3161997_3163263_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NZ_CP011125.1\|WP_053232843.1\|3176184_3177288_-\|metallophosphoesterase	gnl\|CDD\|277343	cd07398, MPP_YbbF-LpxH, Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain. YbbF/LpxH is an Escherichia coli UDP-2,3-diacylglucosamine hydrolase thought to catalyze the fourth step of lipid A biosynthesis, in which a precursor UDP-2,3-diacylglucosamine is hydrolyzed to yield 2,3-diacylglucosamine 1-phosphate and UMP. YbbF belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.25887e-10
NZ_CP011125.1\|WP_053232825.1\|3164029_3164959_-\|ABC-transporter-permease	gnl\|CDD\|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	4.03344e-06
NZ_CP011125.1\|WP_053232844.1\|3177549_3179634_+\|IPT/TIG-domain-containing-protein	gnl\|CDD\|366832	pfam01833, TIG, IPT/TIG domain. This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.	2.08415e-13
NZ_CP011125.1\|WP_053232839.1\|3174361_3175315_-\|YegS/Rv2252/BmrU-family-lipid-kinase	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	2.488e-53
NZ_CP011125.1\|WP_053232847.1\|3181918_3183067_+\|DUF1517-domain-containing-protein	gnl\|CDD\|369378	pfam07466, DUF1517, Protein of unknown function (DUF1517). This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.	1.49272e-64
NZ_CP011125.1\|WP_083457355.1\|3161285_3162110_-\|ATP-phosphoribosyltransferase	gnl\|CDD\|234971	PRK01686, hisG, ATP phosphoribosyltransferase catalytic subunit; Reviewed.	1.98428e-101
NZ_CP011125.1\|WP_053232815.1\|3158739_3160230_-\|leucyl-aminopeptidase	gnl\|CDD\|234863	PRK00913, PRK00913, multifunctional aminopeptidase A; Provisional.	0

>NZ_CP011125.1|WP_053232829.1|3165979_3166396_+|Hsp20/alpha-crystallin-family-protein
MLTRWDPFTEMSRLQDELFRSSFAPRGAAATRSTFSPAVDVFEDADAIFVQAELPGLKLEEISVGVENDVLTFSGERKSEREEGHYLRERWVGAFSRSFKLPRTVDVEKIEATLKDGILTVRLPKRENVKARRIEVKS
>NZ_CP011125.1|WP_053232827.1|3164987_3165713_-|rhomboid-family-intramembrane-serine-protease
MRFAFPPLTPVVRVILVVLFASFVAQSLLQGLIGLPLFDWLALSPELDVPLAWQWATYPLVEYVGSSAVISRAIDLLLVWTFGAMAESHLGRNRTIQLVVVSVIGGAVLPLVFGLLFRDYAVPAAGAGAISWAMMGAFAVITRGAPVNFVFMPAMSAWHALGVFLVVTALQSMWARTPTPLLIALGALAAAVLFVRWIEQRPAKPTKKAGGNGPRRRGGASHLQVIPGGQSSEDERPRWLN
>NZ_CP011125.1|WP_053232825.1|3164029_3164959_-|ABC-transporter-permease
MGRVWAIAINTFREAVRDRVLYGVLGFATALLLFTLALAELSLDQQERVVRDLGLASISLFSVVVAIFLGSSLLYKEIERKTLYVILPKPIRRHEFLIGKYAGIALTAIVFVAIMGAMQLWLAAIQAGASAMWLVVEPVVLGIALGLALWKAKDRTSVLVPFSLVALAASAGVAQSAGVAVGPTLAALTLDVGEVLVVAAVALFFSSFSTPFLTGVLTVGVWLVGRSADEMATMRSNVLPESVRDLLHGLAWVVPNLNLFVPPHRALTEHVEGSGGPVEYVASAMGYGVLYAAILIVMACVVFRRRDFL
>NZ_CP011125.1|WP_053232824.1|3163361_3164033_-|hypothetical-protein
MTAPAREDGRWARRIARAVGIAGVLLLVLAVRVVTASRAELVEADRLRERGDVDASVAHYRRAARWYAPGNPYSTDALDRLAEIARGAEAAGDRDLALAAWRSVRGAILGARSFYVPHAERLERADEHIATLMAALPPPPVDAGRSEAERRAAHLELLRDVPRPSPFWGLVALLGLATWIVAALAFVTRAIDEEDRLVAAQARVWGTVWILGFGSFLLGLALA
>NZ_CP011125.1|WP_053232822.1|3161997_3163263_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MDNIKVRGGTPLRGTLRVSGAKNAALPILCSALLADGEHVFRNVPDLRDIVTTAKLLEHMGLEVDVNPPVVTVRAKPVLEPDAPYELVKQMRASVLVLGPLVARYGRARVSLPGGCAIGARPIDQHLKGLEAMGAEIDLSHGYVNVTVPSGRLKGAEIHLDIPTVTGTENLMCAAVLAKGRTRLANAAREPEVEELACVLNKMGASVEGAGTDVITIEGKDELHPVDHAIIADRIEAGTYMVGAAVTGGNVLLEGITFDHIEALCAKMRSAGIVVEREAGGIRVVGRPPFKPVDVTTEPHPGFPTDMQAQFMLLMCMANGSSVITETIFENRFMHVPELVRMGARIDIRGRSAFVHGPSKLQGARVMATDLRASASLVLAGLVADGETEVLRVYHIDRGYERIEEKLRALGADIERVKGSA
>NZ_CP011125.1|WP_083457355.1|3161285_3162110_-|ATP-phosphoribosyltransferase
MVRPRCCASITSIAATSASKRSCARSAPTSRGSRAVPEKRPTLRALGGRGVTIAVPKGRILKPLADLLEKVGVRREALLADDRTLMREDREAGVSFLLLKPDDVPTYVEYGAADLGVVGRDVLLEREYDLYAPVDLGIGRCRMMVAGLPDRPAPPRTLRVATKFPNIAAAHYARRGIPVEIIFVQGSVELAPITGLADVIVDLVESGETLRQNGLVTFETICDVSSVVVANRAALKLKRDAIAPILAALEPARAATTDARTASPGTRRASRSAG
>NZ_CP011125.1|WP_053232820.1|3160836_3161280_+|helix-hairpin-helix-domain-containing-protein
MGLVRATIAALAISTLAATPHADAQRRQVATAQTSASRAPAAAPATASAEGVVNIQTASVEELQRLPGIGPSKAQAIVAFRERTAFRRVEDILRVRGIGRATFRRLRPMITVTGPTTLTQDVRSPRRAQSSEDAADAESESEPDGEE
>NZ_CP011125.1|WP_053232818.1|3160475_3160724_+|hypothetical-protein
MESASSRSPLVVYTIVERERDGKKFWVRIGAAFRNRDGSLNAFLDAVPVNGTMHIREARPWNERDAGEVPHDDLAVADALAQ
>NZ_CP011125.1|WP_053232815.1|3158739_3160230_-|leucyl-aminopeptidase
MKVSLTTDAPTKIKADLLAIGVRAGQLGKDTVFKQLDKATDGALAAAAKREDFTGKTGESLRVTVSGLGAPVVLVLGLGDGERKERDVRSIAVKAAQAASRYHHVALVLPEDVPDEERAVRVATEGLITGSYKYTRYLTGDRLPKRRTETAKIAVAKSAAGAKDALRRGTALGETINFVRDLVNAPPNDLTPTALAEAARAQSEAHGLSCKVWDKKGIEKLGMNLFLAVNRGSAEEPRLVHMAWKPAGAKKGAKKIVFVGKGLTFDSGGLCIKPPKSMVDMKCDMAGAAVTIGVLVACARLGLPVEVHGFIGATENMTGPAAYRPGDVFSSLDGKTVEIINTDAEGRLVLADVLTYAAREIEPDYLIDHATLTGACMVALGPWRAGLFANDDELASRYQKAADAEGETFWRMPLDEELRELLKSDIADMKHVGEQYGGSITAALFLREFIGQSKWMHLDIAGPAFLDRPHGTAPKGGTGFGVTTAVRFLEALGESA
>NZ_CP011125.1|WP_053232813.1|3158033_3158747_-|hypothetical-protein
MRERRRLAIAVALIGGAIAIARPARAHLGHVILRAERYLKLDATEGDTRLVVSLMLGAEEGERVLAAADANGDHEVTRDEADRYLAQWGEGLRTEVPVELDGAPVELAWTDGWLDPIGRVREVPLTVEMVAHLPTDAREHHVVFEDRMVRRETFDRTDVAFRAHDGAEMIACGPERDPARCDEDELGIVRGGAQPTTFGARVRYPTRSESRMPLVALAVGLVALVAGLIAFFVRRRR
>NZ_CP011125.1|WP_053232832.1|3166651_3169588_-|2-oxoglutarate-dehydrogenase-E1-component
MAHDFGVNQGLVEELYLKYRENPAAVPAEWRKFFDTLDEDPFPPRRSSAGAVAAPSSVGTLLTPSAVGTLTAPATNGAHAANGQAAAAAQPAMAARSASDRRSFIPGPETRAATELQSRVSAMVNAYRVRGHLFADLDPLGLAPKPAFDIDLSAFGLENVDPETTFQAMGQQLSLRQIVARLKETYCRTIGTEVTQIEDPEERNWLQHRMESTLNHVDLSREQQLRLLGKLTEAEVWETFIDTTYVKTKRFSLEGGESTIPLLELLIETSAAHGADEVVIGMAHRGRLNVLVNVMELPAHDLLAAFEDAQPEKYKGRGDVKYHLGYSSDRKFAGKNVHLTLSFNPSHLEFVNPVVEGRVRAKQDRREDHHRKRVVPLLIHGDAAFIGQGVVAETLNLANLRGYTTGGTIHVVINNQIGYTTEVEDARSTRYCTDLVRMLRCPVFHVNGEDPEAVAQVAKLAAEYRQRYGKDVVVDLYCYRKYGHNEGDEPRFTQPVMYRAVDSKKTVRQVYVDRLLELGKITPNEADAIMQERRERLSKALHEVRETKRTYEPSAFTGVWTAYQGGPDASAPDAPTAVAKSTLVPLLNTLAHVPDGYQLMRQVAGVQQQYRDAAEKGSGIKWGVAENLAYATLLAQGYNVRLTGQDSRRGTFAHRMAVLHDTNTGNEFVPLHHLGEGQGRFEIYDSPLSEQGVLGFEYGYSLDSPDALVIWEAQFGDFANGAQVIIDQFLVSGEDKWHRLNGLVMLLPHGFEGAGPEHSSARLERFLALAAEDNIQVVNLTNAAQIFHALRRQVVRPWRKPLIVMSPKSLFRAAEATCTLDDLATGSFQRIIGDAEIAPKKAKRVILCSGKVYYDLAQYRHKLGRDDVAIIRLEQLYPLRPEEIRDVLSVYADGTDLVWVQEEPFNSGAWYFLNARLPSMIEYRLPLRCVSRVESASPATGSGKAHALEQQQLIEEAFANIGAKTARASTRPRASTAS
>NZ_CP011125.1|WP_053232833.1|3170050_3171748_-|acyl-CoA-dehydrogenase-family-protein
MKVTPFNQPPPALGNQYDEDRPLRSLLARIVPRDALLSIEPALRDLGELAGGELYRMQLDDRENDPKLVHWDAWGNRIDHIEVSPLWKRAERIAAEKGLVATAYERRLGALSRVHQFSLVHLFGPATDIYACPLAMTDGAARTLLESGNAVLAERAVPRLTSRDPDRFWTSGQWMTESTGGSDVGRSETVATKDESGQWRLWGRKWFTSATTAQMSLTLARPEGNGPGGRGLALFYVETRDQDGRLRNILVHRLKDKLGTRKVPTAELTLDGTPATPVIGLDSGTKYISPMLNVTRTWNTVMAVAGMRRGVALARDYATKRVAFGAPLSEKPLHVDTLAGVAAEYEAALQLAFFVVQLHGRIEAREASDRDVLLARLLTPIAKLVTGKQAVAVASEVLESFGGAGYVEDTGLPVLLRDAQVLPIWEGTTNVLSLDTLRALGHGPDVAAALEQEMESRVGTISDTSLREVAERARGAVRRALGWLASTYSSSPLDVEGGARRFALTLGRSLELLLLAHHADWSLRNERDARSRAAALRFARAPFDLVEDTPVADLRALANDEPLAV
>NZ_CP011125.1|WP_053232835.1|3171802_3172432_+|hypothetical-protein
MERDLAGRCGSCSFFISYRETEDGAQEGECRLGCWVPPLRDDNTCSHFKQRGTSFDGALKRKVAAGTPRRMREEEARASEPKKPLPQEIDIDMDQDEFRRVLREVLLEELGVGDVAMGDRWRGGEMILKPGKDGTQPKSVPLDQFFHKIVMLRDKLRVLEQKVNSSKGLADDEKVQLQQYITACYGSLTTFNALFRDREDYFVGQGTKE
>NZ_CP011125.1|WP_169791435.1|3172784_3174278_-|apolipoprotein-N-acyltransferase
MTRALRAVLLGGAGGACIAVAGSPIELVALAFLGPALLMLAIDDREITPRVALLAGASCGFVCNAITTSWIVPLLEEYAAFPLVAGIAVGALMWIGQALPFAVAAWLAAPLIARGIAGWIALPITLTIAGSIAPMLFPWRLGVSQMPGVTFVQLAELGGPPLIDLALALGSCAAMHALRRRDARVAIVAALVIATPYAYGAWRIDAIQAQREAAPSLRVGVVQPNLGVREKHDPFLRDAHLRLHRDMTRELEAQGVELVLWPESSYPSYLPHDPGRDVRAIGRILTDGVRGPILFGALTEAPGRRYNSVIGLAREGRVTGIYDKVNLLAFGEYVPLWDFLPPLQRVVRRGFTHGVAEGVVPIAGARVGVLNCYEDLLVEHARLTAARGPSFLANFTNDAWFGDTSAPHLHHMLARLRAVETRRDLVRAVNTGISGLVLATGEDAGRTAPFVRTSFVAEVRLLDGAPTPWVRFGDLVTPALLGVYLAMALARRRGAPR
>NZ_CP011125.1|WP_053232839.1|3174361_3175315_-|YegS/Rv2252/BmrU-family-lipid-kinase
MDRDSFLLVVNPRAGAGRAEKRLPALSDALHAAGAKFEVARTAGPRHATEIVRDALGRGVRGIGVVGGDGTLNEAVNGFFDGDGRVIDPDAWIGPLSCGTGGDFRKTIGSPDVGAGGRGMDALASRFVAATPRPLDVGWLEMLDHDGAPARRAFLNIASFGVGGLVDRLVNETPKWMGGTPAFFLGTVRALARYRSQRVRVRLDDGAARETKIVNMAVANGRFFGGGMQIAPRAEIDDGLFDVVGLEMDVSASFGLTSRIYRGRHLDRPGVSFERARRVRAEPVSEGDHVLLDVDGEAPGRLPATFSVRASAIHLRG
>NZ_CP011125.1|WP_053232841.1|3175337_3176195_-|hypothetical-protein
MPTDHVRATCALVLAGALSIACEERDPAPFAPERDGAIERPDGGPLVITRRDAGQRDAGIDAGAFDGGDLGDAGVGLPVVDGVIGEREYELGIDDVTSSTPPTGLPDQLTRLLVVRTATRLWIGIEGNVGPGRGMMLLLDAAYGGEDGVTLTAGSLADNVGTLDRALSSAVLFSAEDSFRPEYAWGALAEVPFTIDGSEDDVGWREITTADDFADLPSGNRTVCSEDACETSIPIGGTGILRAGTIAIAVRTIDANGLLSSQTLPLDEPGAPESISNVLRVFPPE
>NZ_CP011125.1|WP_053232843.1|3176184_3177288_-|metallophosphoesterase
MKLLRLVLSDLHLGTGVRRGELNAFEDFRHDDEFADLLAHHDREVGEHGELELILNGDVFDLLKVKIDGRWPTEITDEIATEKLRQCLDGHPRFVHALRALLAKKGRRLVFLPGNHDLDMVLPGPQELFRRYVAPGPLGERVRFVTSTDTYHLPEGIQIRHGHQLERIHRVDYARLTRKLRDGREILDLPWGSLWILDVMNPAKEQRSYVDRIQPLGRFLLGAFVFDTMFVLRFLYHSSLYFLRRRVFDIGAWVERIRRLPQMLREDIIALGGFDEVVHRELKKLRGVRCLIIGHSHGPRYLQMPGGKLLVNTGTWMKMINLDVSHLGQDSGLTYCTIDYSEDGDPRISLVKWHGMRKPYEVIPYAD
>NZ_CP011125.1|WP_053232844.1|3177549_3179634_+|IPT/TIG-domain-containing-protein
MAATSLAVGCDRPGAIALPDAAGIDATVPIDSGVPTFSDSAIANTSLSLDRVVPSHGPFVGGNQVILRGTGFTDDAQVTIGGRAVQPADHQLIDSRRLAVIVPAGDVGPADVEVQVGDETVVLEDGYVYDALYVDPSRGSIAGGTFVTITGSGTTFATGDSVVFGRMPCTNVTVVSETRITCRTPASSAGEVDVTVLRAADGHMDTAEDAFEYYDTSDPLNGGLGGGTISGSLNVTVVDWLSDAPLEGAFVIVGQDLDTPHQGLTNALGQITFSGPDLVGPLTVHVAKDCYQRTSVVAFDASDVTVFLRMWDPLTLPERCRADGEPPPPTGGRGRNLSFVEGDLIWRGPNEYGPNPWANIPEPREGWERVAYVYTTVREIGLANPDPAGGGAHQRVIEVLPDDGTQHLGYPYRILAYPRGMAVYALAGLQERRTGGRFIPYVMGVARSVLAGPGDTVSGVDIVMDIPLDHYVDVDLGVLPASTPVGPNRFRVQAFLDLGGEGLIRRQVGAQDFDTLRRYDAARDFRFVSQPALSGTIADGRYRITAGWFTGDADGEPFTYAVVNGVTAVDETVPMPDFLGVPMAVAPSVGQSLPADRILRWRAEGGPAPDLYWLLIFSEDGNLAWEMFVPGSVTEAPMPDLSTIPELFDVPDGAIYWQVRAASIPGFDFDELSYAQLSDRYWSHSARNTFIVQR
>NZ_CP011125.1|WP_053232846.1|3179655_3181776_+|hypothetical-protein
MVFVRSLTAACAAVAIASLCSCTQGRSDPDRPDGGNNPIIDGGFVCLSETSEACLGDVHYSCEADGEFLRPVIEDCAEQGKTCADGLWCVTCRPNSGGCDEQGNAVVCRDDGSGWDLVDECDIDNGEVCDLGSCRNLCELALTRRSYLGCEFYATDLDNASLGAGRDASAQQYAVVVSNPGNYAADVIVEIDTGAFGGATVPVIVAEQRVLPGDLEVFELPRRELDGSSSMVPCAADTECQSAIEACWCSGGDPVGTPGATDCRCRNAPGTNGMNDGTHSALTAHAYRVRSSLPIVAYQFNPLDNVGVFSNDASLLLPTSGIGERYTVVGWPQTIADSTNPDEDFDPSRTDEDLRAFLTIVGTQPDTHVEITLGPQVRNVVGLGEDDNYVAGDVIELDLGEFDVVNLETQGFNADFTGTRIVASPERPVAVFVGTEASDAPRYETLLNRQCCGDHVEEQLFADDALGRHFFIGLTPRRSRALSAALIDGSSVGDFAEPESVRIVAVAEGVTTIDTTLDDGFGGFLSYELAENESLVIETTHDFEIRSSQAIAVLQVQSSQESIGIDSRYPGGDPSIVGVPPVDQYRRDYVFLTPDLYAFDFVTIVAPATAQILLDERPLTEFECEAAAADGIERMMDDPPPEWFVYRCQLSYPDVIGPPNVEVEDGVQNDGYHTLRATEEVSLIVSGFDAYVSYGYAGGADLESID
>NZ_CP011125.1|WP_053232847.1|3181918_3183067_+|DUF1517-domain-containing-protein
MSPSRSALRSFLLTLLFALVIAIAGPARVDAQGTGGSFGGGDWSGGGGGGSGGGGGGSDWGGGGGGSYGGGSYGGGGYGGSYGGGGYGGSYGGGGGGMGCGGACCLLMFLGLFITIAIVNQRRRAAGGGGGGAPFMPMGMPGGGAGGYSGPNAMYLSQIQLGLDWRARAQLQQHLMRLAQTGDTRSPSGLAQLLSESVLALRRHEMSWLYAATKDGGGMQPQQAQGAFQQWANDARSRFQHELVRGHQGGMQQQQGPEMTAHAHEGQGTVVVTIILATRRPVQGFMVPDASQIRNALSDRGAILPNQMVALEVIWSPAAENDRMSTSELEQNYPELKLIDPNSIAGRVFCAYCSGPFPMELLNCPHCGAPAEASKGRREPPR

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Crispr_ID: NZ_CP011125_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_14

3262338-3262646

Orphan

Consensus_repeat	Method
GGCGAATCTCGGAGATTCG	CRT
GGCGAATCTCGGAGATTCG	PILER-CR

7 spacers

The CRISPR arrays of NZ_CP011125_14

>merge|NZ_CP011125|14|3262338-3262646|CRT,PILER-CR
GGCGAATGTCGGAGGTTCGGGGTCTCGGTCGGGGACCGGCCGGCGAATCTCGGAGATTCGGTGGTCGATTCTGGAATCGGCGGGCGAATCTCGGAGATTCGGTGATCGATTTTGAAATCGGCGGGCGAATCTCGGAGATTCGATCCCCTGGATTCGAAATCCACCCGGCGAATCTCGGAGATTCGGTCGGCGATTCTGAAATCGGCGGATGAATCTCGGAGATTCGATCCCTGGATTCGAAATCCACCCGGCGAATCTCGGAGATTCGGTGGTCGATTCTGGAATCGGCGGGCGAATCTCGGAGATTCG

>NZ_CP011125|14|1|3262338-3262646|CRT
GGCGAATGTCGGAGGTTCG	GGGTCTCGGTCGGGGACCGGCC
GGCGAATCTCGGAGATTCG	GTGGTCGATTCTGGAATCGGCG
GGCGAATCTCGGAGATTCG	GTGATCGATTTTGAAATCGGCG
GGCGAATCTCGGAGATTCG	ATCCCCTGGATTCGAAATCCACCC
GGCGAATCTCGGAGATTCG	GTCGGCGATTCTGAAATCGGCG
GATGAATCTCGGAGATTCG	ATCCCTGGATTCGAAATCCACCC
GGCGAATCTCGGAGATTCG	GTGGTCGATTCTGGAATCGGCG
GGCGAATCTCGGAGATTCG

>NZ_CP011125|14|3|3262461-3262646|PILER-CR
GGCGAATCTCGGAGATTCG	ATCCCCTGGATTCGAAATCCACCC
GGCGAATCTCGGAGATTCG	GTCGGCGATTCTGAAATCGGCG
GATGAATCTCGGAGATTCG	ATCCCTGGATTCGAAATCCACCC
GGCGAATCTCGGAGATTCG	GTGGTCGATTCTGGAATCGGCG
GGCGAATCTCGGAGATTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053232904.1\|3255315_3255534_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232902.1\|3252642_3254250_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP011125.1\|WP_053232905.1\|3255643_3256723_+\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	unknown	unknown	gnl\|CDD\|236947
NZ_CP011125.1\|WP_053232908.1\|3259906_3260164_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232907.1\|3258956_3259796_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226354
NZ_CP011125.1\|WP_053232916.1\|3270402_3271599_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232911.1\|3261448_3262285_+\|TonB-family-protein	unknown	unknown	gnl\|CDD\|367555
NZ_CP011125.1\|WP_053232910.1\|3260999_3261437_+\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|223917
NZ_CP011125.1\|WP_053232921.1\|3277204_3278038_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP011125.1\|WP_053232913.1\|3263528_3264977_-\|DUF1552-domain-containing-protein	unknown	unknown	gnl\|CDD\|377875
NZ_CP011125.1\|WP_169791439.1\|3254357_3255140_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP011125.1\|WP_053232918.1\|3273468_3274074_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232912.1\|3262661_3263450_-\|DUF1517-domain-containing-protein	unknown	unknown	gnl\|CDD\|369378
NZ_CP011125.1\|WP_053232909.1\|3260335_3260995_+\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|223881
NZ_CP011125.1\|WP_169791440.1\|3264973_3266626_-\|DUF1592-domain-containing-protein	unknown	unknown	gnl\|CDD\|377886
NZ_CP011125.1\|WP_053232906.1\|3256719_3258960_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|224096
NZ_CP011125.1\|WP_053232920.1\|3276172_3277048_-\|phosphatidylserine-decarboxylase	unknown	unknown	gnl\|CDD\|234591
NZ_CP011125.1\|WP_053232919.1\|3274070_3276176_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_CP011125.1\|WP_157069024.1\|3271894_3273382_+\|thrombospondin-type-3-repeat-containing-protein	unknown	unknown	gnl\|CDD\|380149
NZ_CP011125.1\|WP_157069023.1\|3266823_3270393_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|338048

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053232921.1\|3277204_3278038_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.0973e-12
NZ_CP011125.1\|WP_053232902.1\|3252642_3254250_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	3.86683e-25
NZ_CP011125.1\|WP_053232905.1\|3255643_3256723_+\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	gnl\|CDD\|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	3.72596e-179
NZ_CP011125.1\|WP_053232907.1\|3258956_3259796_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226354	COG3833, MalG, ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism].	1.40035e-81
NZ_CP011125.1\|WP_053232911.1\|3261448_3262285_+\|TonB-family-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	3.51321e-10
NZ_CP011125.1\|WP_053232912.1\|3262661_3263450_-\|DUF1517-domain-containing-protein	gnl\|CDD\|369378	pfam07466, DUF1517, Protein of unknown function (DUF1517). This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.	4.47763e-09
NZ_CP011125.1\|WP_053232910.1\|3260999_3261437_+\|biopolymer-transporter-ExbD	gnl\|CDD\|223917	COG0848, ExbD, Biopolymer transport protein [Intracellular trafficking and secretion].	1.14843e-31
NZ_CP011125.1\|WP_053232913.1\|3263528_3264977_-\|DUF1552-domain-containing-protein	gnl\|CDD\|377875	pfam07586, HXXSHH, Protein of unknown function (DUF1552). A family of proteins identified in Rhodopirellula baltica.	2.9209e-27
NZ_CP011125.1\|WP_169791439.1\|3254357_3255140_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	8.67082e-55
NZ_CP011125.1\|WP_053232920.1\|3276172_3277048_-\|phosphatidylserine-decarboxylase	gnl\|CDD\|234591	PRK00044, psd, phosphatidylserine decarboxylase; Reviewed.	7.40115e-89
NZ_CP011125.1\|WP_053232909.1\|3260335_3260995_+\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|223881	COG0811, TolQ, Biopolymer transport proteins [Intracellular trafficking and secretion].	4.98732e-34
NZ_CP011125.1\|WP_169791440.1\|3264973_3266626_-\|DUF1592-domain-containing-protein	gnl\|CDD\|377886	pfam07631, PSD4, Protein of unknown function (DUF1592). A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match pfam07627, pfam07626, and pfam07624.	2.10609e-35
NZ_CP011125.1\|WP_053232906.1\|3256719_3258960_+\|extracellular-solute-binding-protein	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.05045e-79
NZ_CP011125.1\|WP_053232919.1\|3274070_3276176_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	6.21117e-26
NZ_CP011125.1\|WP_157069024.1\|3271894_3273382_+\|thrombospondin-type-3-repeat-containing-protein	gnl\|CDD\|380149	NF012181, MSCRAMM_SdrD, MSCRAMM family adhesin SdrD. Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.	1.34823e-11
NZ_CP011125.1\|WP_157069023.1\|3266823_3270393_+\|hypothetical-protein	gnl\|CDD\|338048	pfam11617, Cu-binding_MopE, Putative metal-binding motif. The seqeunce of structure 2vov is not matched in any other sequence either in UniProt or in NCBI (Sep2014). The model is of a short repeat not found on the G1UBC6 - 2vov - protein. The presence of conserved cysteine residues and the lack of hydrophobic residues suggests that this repeat might be a metal-binding site, perhaps for zinc or calcium ions.	3.93845e-05

>NZ_CP011125.1|WP_053232911.1|3261448_3262285_+|TonB-family-protein
MGDGAAGLARVFGMLVLSTGAHVAVAFVLIALPLARELIPNEPQMIEIVAIDEPLPPEPEPEPVVEEPEPPPPEPEAVRPEPRRVERTEPRPSTPEPQPEPPSAEPPPVEEAIADFTGETLTNEGGETFAMPVGNGAPMDGPIGQPGAVVTGRRREGGSGGAIGGSGTAAPEGPRVVALADLSRRPSPQGDMNAVLQRNYPPRARQLGIEGRVVIGFRIMPDGSVQRFRTRSETPPSQGFGEACRRTVQQLRWDPPLAQDGAAVATDASFECEFAVGL
>NZ_CP011125.1|WP_053232910.1|3260999_3261437_+|biopolymer-transporter-ExbD
MGGGTGGGGDDDLITSINVTPLVDVVLVLLIILMVTASYIVSHSIPMELPQAETGDPEAQQPRTLTVSINETGQLHIDAEPISDEVFRRRIREYVASLPNRQESRATIAADGRIQHSRFVYVLDSLRREGVTRYAINVRPEDLAQ
>NZ_CP011125.1|WP_053232909.1|3260335_3260995_+|MotA/TolQ/ExbB-proton-channel-family-protein
MDIQERLTAFAMLGATWVMWLLVLLSIVGLAIILERAYYLFVSRDDIAKLKSDLLAKLRSNDVDAARTRMRQSRSVEAQVALAGLDAAEDGAETAEERMDGQTSISRLNMERNLAFLGTVGNNAPFVGLAGTVIGIIRAFHELNESQGQVSAGLMAEVGEALVATLIGLLVALPAVAFFNLFQRIIKARLTRADAMGREVLAFLKSERRKNGVAEAAAE
>NZ_CP011125.1|WP_053232908.1|3259906_3260164_+|hypothetical-protein
MGASTHGDGAAAERVVAHLAARVGLNDIERRVIALSLAGVAPEALPAQLGVDPSLAAAAIRVACVRLEIDSVSEVWRLVRGDLQD
>NZ_CP011125.1|WP_053232907.1|3258956_3259796_+|sugar-ABC-transporter-permease
MKARGRELLVHLVLWIAVLFALYPVTWVVSQALSSGATTGGRILPWPTEPSLEHFEAVVMRVHEGRWLFGLQLLNSVVVSAATALVAIAIATPAAYALSRFEFVGARGATRTLLATQMFPGVAASIPLYLLLDASNLLDTRTGLVLVYATSAVPFAIFQLRGAFDAIPRDLEEAAMVDGATRAGAFFRVVLPAARPALAVTALFAFMTAWNEFILAATFLTSQDLYTLPILLNGYASEYDSNFGHFAAGAIVVSIPVMALFYALQRQLVGGLTAGGVKG
>NZ_CP011125.1|WP_053232906.1|3256719_3258960_+|extracellular-solute-binding-protein
MSFRRTQTRAVLSAALTAVLALLAGVTLTWVSLCLPSAARGQTTTLTLWHSYGEREERGLRAAVDAFEQSHRGTHVEMLAVPFGAYASKLESAIPVQRGPDVFVDAHDRLSSYVSSHLVQPLGAGLEMDDELEQAHLDALTIDSALYGVPLQLKSAALFVNDALLGDRTIESLEDLEALRATLPDGSFPLAWDADDAYQFASLLHAYGGGLLEPDGTYAFVGPRTERALDHLLRLLRTRTIPEETSYELVRDLFRSGRAATAISGPWFASDLPTDLEWSVRPLPIVRGADGEPMRAFATIEAAFVAEGARDLDAARALAIFLATPDAARLRAIHGGHVVATRSVWSDPEVARDTRLVAFRQAASHARITPTHPSMRAVFVPAERALRNVLRGEIAIDEALAQGQHRFDDETREPPPPRDPSTGLLAFGLVLLAMVFGMVRRARDPMFRVALRRSVPAYAWVAHAAITVGVLVILPLVVGAGTSFFAGHGRDLHYVGLANYVDILTARGGDLLGHGSFWAVLVVTVLWTAANISLHVAIGVALALLLNRSTLRFKGLYRVLLVLPWAVPSYVTALAWRGMFHRQFGAVNAMLEALGAEPVSWFARWSTAFAANVTTNVWLGFPFMMVVTLGALTAIPKDLYEAAEVDGATKWQQFRFVTLPLLRPSLAPAVAMGAVWTFNMFNVVYLVSAGEPDGTTEILVSEAYRWAFTRGHQYGYAAAYAVLIFLLLYFGTRALPGSGSAKEGAR
>NZ_CP011125.1|WP_053232905.1|3255643_3256723_+|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC
MSSLSLRGIKKDLGGNPILRGVDLEVGDGELVVLVGPSGCGKSTLLRTIAGLEIPDGGTLKIGDRDVTQLPPRDRDVAMVFQSYALYPHLTVRENLGFGLKLRGTDAKTIAERVDEVAQMLGLEKLLDRYPRQMSGGQRQRVAMGRAIARRPSVFLFDEPLSNLDAALRADVRVEIKRLHARLKEQGQGATMIYVTHDQVEAMTLADRLVVLKSGHVEQIGAPLEVYEKPRSRFVASFLGSPAMNFVPGEIVDGRIRADGLDAQLPQNDRIASKSVLAGIRPHDVLPSANGHADILLRVEVIEAMGFEAYAHGKVGAHPFVARLEGDRARAARPGDTLALDIAQGSLHLFDPDSERTLS
>NZ_CP011125.1|WP_053232904.1|3255315_3255534_+|hypothetical-protein
MARALLFVSLMHRETTHRTPRRTRSTLASAELRRLDHDLVALEAQASTDPVLATMLAAARACRAQLVRDTEG
>NZ_CP011125.1|WP_169791439.1|3254357_3255140_+|histidine-phosphatase-family-protein
MEIVLVRHAESIWNAEGRWQGQTDVPLSEQGRAEAAKLGARLANAHFDRRIASDLMRTRDTAAAIGADFVHDPAWREFDLGAWGGLLHSEVRERFPDEVQAMAMGTDMPIGGAESMVTFDARVHRALDAVIASGRDGERVIVVTHGGVIRSIVMRLLGLRGRPLIGATNTSITHLRVDPERRVRIVSYNCGAHLDASDTPHDDEILEGAPDDIVRRVATRLGIGDAQRVHLHPPRPGSITRLVRGTAHPVLRSFATPAFG
>NZ_CP011125.1|WP_053232902.1|3252642_3254250_-|mechanosensitive-ion-channel
MRSRFRALASWASFVALVAIAGSVRAQGEPAPTTGLPPPDEPLDLSTPRRALRYFDGAVADGEWIDAARVLDLRDVPPERAVPRGEGAARAIDAVLTDRGVTPESLPDEAEPGGSHVVGVAWIPGVEPGVVMRRLLRDGRPVWVFSRTTVRVAPDLAARIDRGPIGNRLGPALREPRFAELEPWQWIGSALALVIAAVLATATGRALVWLVWRSLRREERAKLGRAVKRVRPPARLALTLAYLGLLAILLRYPPSIVAVLADAYRAAWIVAVGWLVVRGIDFAAQAASERAAARQGWRARMVRTRVILLRRALNVVATVVFASVLLLQFPPVREVGVSLLASAGVAGVVVGIAAQRTLGNLLAGIQLSFTQPLRVGDQVVIENEFGTVEEVNLSYVVVRVWDQRCLIVPMARLLELPFQNWTRAADDLIGDVFFYVDFATPIERLRPEIERFVRAHPLWDRRVLGVQVVEATERAAKVRVLVSARDAGSTWDLRCATREFVLGLLQRLEGGRYLPRMRLDDVERPSEGSGARRLS
>NZ_CP011125.1|WP_053232912.1|3262661_3263450_-|DUF1517-domain-containing-protein
MSGAGWLHGLALALAVLAALATTASAQASTRRPRPFPPEQAAHLRAVARENVVLVLATAAAGAVLAGWALSRRRSRTRLASDTPIRIEQWDLAVVEVALAREHVASLRRELDEILASRLNARDVLPELANALARAPWSHVGMRQYPRVDAPIAEQRHRAVQTEIAARETLEVPPEPGRGYRGEPMRDEPEEHALVSLLVLTRAELPEALGAPPDAARRTLESLARRPTSEIVQVDVTWFPPGAGETTTTRDLLARAPRLVPA
>NZ_CP011125.1|WP_053232913.1|3263528_3264977_-|DUF1552-domain-containing-protein
MTTILDRRRFLRAMGLSALASAGASTALGRSIVHAGDDDAPPRRVVFFCTGHAHVWNGWHVALPGLPTDRTVERSLLELSRDELSPVLRPFHAMRDRVLPIEGIAHTSVLGDLAALAGQTGIDANHHNVAMAHLLTAQIAQQRGPGAICIGGGRSIDQEIGARVSQPGRFDACVWGANHWMPYSFLGAGHAAPRVDDPERAYADLLGLYVPPASDTPATRDERIRALRGSVLDAVAREHEFMRTRMGLEGARKLEQHRDMVRDLERALGIAVPTRCDPVFESTGHVIDQYSRLATLALSCDLTRVVTIVPPILEPTEFGYPASSDVHGRFAHSSVDDGSEPFDPVSERAMIDYGIFYSQRFLALLEMLDAVPEGSGTMLDHTTVVWLTELGSPTHQHVDACTLIAGGTDFFRTGRYVRYARDVRAAMDWAGRPLSHGPALSQLFVTLLRSFGWDDDHFGMREVTRGDGSTIDVRGTLRELHV
>NZ_CP011125.1|WP_169791440.1|3264973_3266626_-|DUF1592-domain-containing-protein
MRHAVPLAVILLLAALSGCGDDLPIARPLPTGRATPSLPEPLRRLSRVEHERTLRDLFPGTALPLLELPPDTELDRLENDARSLGPSQLGIARYEESARAVASAVMADERARARVLSCDAWSTPSEQEACVDAFVAGFAMRALRRPPSEDEAERLRSRIRAWTTQTDFLGAIELAVQMLLQTPSFLYRTEPSVDDDDEIIAVDGYEMASRLSYALWQSMPDDALFEAAASGALSSREGVEREARRMIADARAGDTIVDFHRQWLDLDRILEPEHAVRADGTRSDWDARTQRDAHAEALRFVRIALVEGDGRLASLLESPEAELSGRLARLYDVGTDPSWADDEWRRVTLPDERRAGILTRVAVLASHAHPGYASPPLRGSFVLETLLCAPRTSPPADVDLSQPRPSDGEGPRTNRELFAQRTSSALCQGCHVRLDGIGFGLEHYDAAGVWRDVEVGVAIDTAGALHGTDVDGPFDGALELSRRLATSRDVHACYTRRWLQFVRGRPADASEQFLLAELEERFAESGGDVRALMLAIVTHPSFARRTAVGE
>NZ_CP011125.1|WP_157069023.1|3266823_3270393_+|hypothetical-protein
MRFRAWYARCSGAASMLDRRRVVVLAVVVIVACEAPPPATPDGGIEADAGPELCVLDRECQNGVFCDGEERCMPGATDADQRGCVPAYVAACEPGYVCEEDARRCVTDCPVALDADGDGRIATECGGDDCDDGDRNRFPGNTEVCDAAGHDEDCNVATFGFVDDDGDGSASETCCNADDEGAQCGDDCDDGDSLINPRAGEACDRVDNNCDGVADEVCPCAPGAAEVCGTGEGACQEGRRVCVEGIFGECIGAVGPAEELCDGVDDDCDAIVDEHVLRTYHEDTDGDGYGSATSGVTTSACSVPEGWASNTLDCDDARAGVSPAAPEVCNDLDDDCDGTTDEGLRRVYHLDGDGDGFGGAANAAGATCGPPSASYVERRGDCDDARAAASPVGIESCNGADDDCDGRTDEGVLRTFHRDQDGDGAGGATTSTGCTAPSGYVTLGGDCADTDAARHPGRHDACNAIDDDCDGTTDPGCTCTDGARRDCGTGPGGGAPTNVGECAIGSQICVGGSWGSCVGDVASSAEVCDGLDQDCDGRTDEGTVVATCLGDGDGDGYGAGAATRQCRDATRASAGFCPPGWTTTGGDCNDANASARPMATESCNAIDDDCDTTIDEGTTATGCFPDADADTYGIGSATTQCRDATRGAHGFCPLGYTSRGGDCNDSSSAIRPGATEACNGRDDDCDAAADDGAGMICALGTVRAGTGAYGSCASVAGTYACNAGCTTETFTPAPPSETCNGGDDDCDGAIDDVFECRQSSSGHACVTGCGTVGTRSCSASCSFGGQTCRGTEICNGCDDDVDGSADDGFACRLGETRSCTRACGGGSVAGTQRCLADCSGWSDCTATETCNGCDDDGDGSVDNGFFCPRNAITYCTTACGTAGQQICNASCSAHTETACYASAESCNYCDDDGDPSTSDASLANGIVTDLYTCSAFRAASTTTTCSTLTSRTYTLVNGAANDAGAIWLDSPAAMRRLGWGPMSFVAEVTAGRSASPTTYPADGWAVILGRSGSGDLGAVGGGLGVPSTRDGLVLEWRYYTGVPSSQSDQVQVVRQSGGTRTVLGTVTPPSAHLDSTSSSDVTQRLFIEYTPDDPRTVTSEERLRLRFAVNGPIALDIAPSPSSCGGSICACDPPCASPSLSRELVPGEPFQVGFSAATGGAVSMARVELNGALVGGGPYTRAQRSNVCF
>NZ_CP011125.1|WP_053232916.1|3270402_3271599_-|hypothetical-protein
MHRTALVLASALAACAPDQPATGLALHLTATDAEGATYRLRDATFAIAGPETTSASTETDPDAATISLELAAGTYAVTLADGWRLERVVAGEATDVTATLVSPNPVSATVVAAASTQVRFRFAVRGDVVETGPGQLDIGIEVERETAGDEIVLGPWNTGAGTEETLCLVVDAGGITGKRVRAIHVTPSPGTYEVEIARTTAPLTEGATTCPGDIGSAPLFVATAAPASLVLPDDTELVLAPHEHVRILQRVANTSDADVESSVHVELDVLDPGAPARDALSVSLLFDWMFACPPHTTCATSSFHAMPASAELVALTTLTRSRADATVRHAASAADTTGALIHDAVDWSAPGTTIAAPRRTFGGEDGLRLTCTITADDSTLTAGLSSRDEICAALAYHR
>NZ_CP011125.1|WP_157069024.1|3271894_3273382_+|thrombospondin-type-3-repeat-containing-protein
MRRIALVVGTLTCLLVAWTNHASAQPLGEFNVLRYHPAPGPNNYFGVDGAAVRGEVAGAAGVQLDYAHEPFTLYSATCEAGDAGCETTGIEANVVQYTAAAHLWGSIALFNRIQIGLNVPLVLTEGDAFPNPAGPGDLISSGSGFTLGDPRLHVKANLLDDASGLRLGLAAWVTAPVAVHIAEGRFVGDEDPSFGGHAIIEYVNQGVHVAGNVGGYWRDGDTLFSTVAGPALSYGLAFGYDITPLVMVFGEIQGSTAFSGQVDENPLEARLGGRLRVDDVVFELGAGAGLVAGVGVPVFRVLGGFAWAPQRADNDGDGIDDSMDSCPADREDLDDWHDDDGCPEPDNDSDGLADGADRCPNEAEDMDGDADDDGCPDLDTDGDGVHDGYDSCPTQAEDMDGDRDDDGCPDADRDRDNIEDSADQCPDQPEDTDGFGDEDGCPETDFDGDNLPDDGDQCPDQPEDADGFEDEDGCAEEAGPPPAEETPADRRRRGR
>NZ_CP011125.1|WP_053232918.1|3273468_3274074_+|hypothetical-protein
MLVVALVGTPFVLACRDVDSTSGTSIGSFDVHGTLDENGCAPGLDSIDPLEFRVDLAREHGTLTWRMQGGGPVFGTIEDDGEFRVRSSTEAEAWPEDPVNGIRGCRLTQIETIEGTIRDLPRADGGTSMPDAGTQGDAGTQGDAGTQGDAGASARPTFEASHRIEVVPVAGSDCSPLLIVHGGSFPTLPCSARYDLEAEAD
>NZ_CP011125.1|WP_053232919.1|3274070_3276176_-|methyltransferase-domain-containing-protein
MTDREHGDGPDGEGSSPDTLALAERPSRRRTGRRRSLRVPVDEVPRRSTSPDGELAAVSTPEEQDPFAPMPTERTQVSAAVAAATTTSELGMELADVDLAEELDADELQVDDEPGAAAPSLEEEPTRIAATPSAPALGSPSTEPELERVRETDPGAQPAMSERPPPSQPPVDAERTSPGVTRAADEPRASMPSAQPAVIVSRVVAISSPPPAPTPTQAAAPTPSWPSHDEEPELSISESFDDLEVDVGDDERDMMSALADEELGDDALDAGDALDEDDALDDDAALDAAATARAPEDDGDEVSAAELELPDDELTDAAKPPPPPARAQRPADEEELAADDLEVEASGETDSLDPKKRSAPPPPPDKPARAAPPARPAGATSATPTAAAPASATATASSTATASSTTTAQEPAAEPARRSKKKGNWWEDFFNDDYLRTVPPPNPRQIARQCDFIEQRLALKEGSTILDVGCGLGLHAIELTRRGYLVVGLDLSLPMLSRAADEAQDQGFRINFLHADMREMNFDGAFDAVLCWGTTFGYFDDDQNRGVVERLHRALRPKGKLLLEVVNRDFVVPTQPNLVWFEGDGCVVMEETQANFITSRLTVKRTVILDDGRQRDNQYSVRLYSLHELGQILHQRGFRVVEVSGREATPGVFFGADSPKLIILAERRIQQAAPPPAPKKTGSMDAVDAPTTDSSESGAES
>NZ_CP011125.1|WP_053232920.1|3276172_3277048_-|phosphatidylserine-decarboxylase
MLASRIAAETLRFLPRKRISRVLGRMASAGVPLPLLQRAIELYVRAYAVDLSECDVPSGGWTSFNQFFTRPLRDGCRPIDPDPGAIVSPADGLVEDCGTIDARATFRVKGRPYDVGELLGDARDASRYEGGRFAIIYLSPRDYHRVHAAVEGPVRVVRHVGGTLFPVNKIGLEHVPGLFAKNERVAVFQESPLHGEIATILVGAIVVGSVTLTFDPAMRTNDGPPRGTVRYLPGREPTLGRGDELGAFQLGSTVIVLTTRRSDIELAVDPGTPVRMGQAIARRVRDGRNVS
>NZ_CP011125.1|WP_053232921.1|3277204_3278038_-|class-I-SAM-dependent-methyltransferase
MRDEHRDTNKRNWDERARVHARSKFYDLDGFVAGARGIWLHPCEREELGAIEGRSLCQLQCHLGVETLSWARLGASRVVGLDFSHDAITAARDLAQRCGLADRARFVESDVHDAERALADEAPFDVVYVSVGAICWLPSITRWARIVRALLKPGGVLYVREVHPMMNGVFERDGKLVVEGPYFEREEPTRWDDGTTYTEGGPKLENVTCFEWAHGLGEIVQALLDVGLVIEMLHEHRDAEFQPFESMTRGDDGLWRLPEAWRDRLPLTFTLRARLPG

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Crispr_ID: NZ_CP011125_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_15

3330114-3330469

Orphan

Consensus_repeat	Method
TGGGTCGGACCCATCGAGATCGA	CRT

8 spacers

The CRISPR arrays of NZ_CP011125_15

>merge|NZ_CP011125|15|3330114-3330469|CRT
TGGCTCGGACCCATCGAGATCGAGTTCAGGCTCGGCGGTGATGGGTCGGACCCATCGAGATCGACTCGAAAGTCGTCAGGTGATGGGTCGGACCCATCGGAGGTCGACTCGAAAGTCGTGAGGTGATGGGTCGGACCCATCGAGATCGACTCGAAAGTCGTCGGGTGATGGGTCGGACCCATCGAGATCGACTTCGAGCTCGCCCCGCGATGGGTCGGACCCATCGAGATCGAGTTGGAAGTCGGCGTGGATGGGTCGGACCCATCGAGATCGAGCTGGAAGTCGGCGTGGATGGGTCGGACCCATGCCGATCGAGCTGGAAGTCGGCGTCGATGGGTCGGACCCATCGAGACCGA

>NZ_CP011125|15|2|3330114-3330469|CRT
TGGCTCGGACCCATCGAGATCGA	GTTCAGGCTCGGCGGTGA
TGGGTCGGACCCATCGAGATCGA	CTCGAAAGTCGTCAGGTGA
TGGGTCGGACCCATCGGAGGTCG	ACTCGAAAGTCGTGAGGTGA
TGGGTCGGACCCATCGAGATCGA	CTCGAAAGTCGTCGGGTGA
TGGGTCGGACCCATCGAGATCGA	CTTCGAGCTCGCCCCGCGA
TGGGTCGGACCCATCGAGATCGA	GTTGGAAGTCGGCGTGGA
TGGGTCGGACCCATCGAGATCGA	GCTGGAAGTCGGCGTGGA
TGGGTCGGACCCATGCCGATCGA	GCTGGAAGTCGGCGTCGA
TGGGTCGGACCCATCGAGACCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053232954.1\|3322911_3323577_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371690
NZ_CP011125.1\|WP_053232958.1\|3327639_3330051_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_169791445.1\|3336953_3338504_-\|CapA-family-protein	unknown	unknown	gnl\|CDD\|378215
NZ_CP011125.1\|WP_053232967.1\|3338584_3339274_+\|CAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|131955
NZ_CP011125.1\|WP_053232962.1\|3333100_3333349_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|179197
NZ_CP011125.1\|WP_053238806.1\|3322123_3322900_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|226591
NZ_CP011125.1\|WP_169791443.1\|3335104_3336064_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|184875
NZ_CP011125.1\|WP_053232953.1\|3321212_3322127_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|236565
NZ_CP011125.1\|WP_053238808.1\|3332255_3332666_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NZ_CP011125.1\|WP_157069031.1\|3324849_3325932_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791444.1\|3336224_3336953_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232960.1\|3331534_3332269_-\|carbohydrate-binding-family-9-like-protein	unknown	unknown	gnl\|CDD\|187678
NZ_CP011125.1\|WP_053232952.1\|3318845_3321194_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275303
NZ_CP011125.1\|WP_053232959.1\|3330520_3331432_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069030.1\|3324277_3324841_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232963.1\|3333389_3335069_-\|fatty-acyl-AMP-ligase	unknown	unknown	gnl\|CDD\|341254
NZ_CP011125.1\|WP_053232961.1\|3332813_3333056_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|376348
NZ_CP011125.1\|WP_053232951.1\|3318372_3318795_+\|hemerythrin-domain-containing-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053232955.1\|3323693_3324218_-\|O-acetyl-ADP-ribose-deacetylase	unknown	unknown	gnl\|CDD\|394878
NZ_CP011125.1\|WP_083457371.1\|3326437_3327487_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|223704

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053232954.1\|3322911_3323577_+\|hypothetical-protein	gnl\|CDD\|371690	pfam11717, Tudor-knot, RNA binding activity-knot of a chromodomain. This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding.	0.00012853
NZ_CP011125.1\|WP_053232958.1\|3327639_3330051_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.78888e-50
NZ_CP011125.1\|WP_169791445.1\|3336953_3338504_-\|CapA-family-protein	gnl\|CDD\|378215	pfam09587, PGA_cap, Bacterial capsule synthesis protein PGA_cap. This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.	2.22213e-65
NZ_CP011125.1\|WP_053232962.1\|3333100_3333349_-\|acyl-carrier-protein	gnl\|CDD\|179197	PRK00982, acpP, acyl carrier protein; Provisional.	1.63033e-11
NZ_CP011125.1\|WP_053232955.1\|3323693_3324218_-\|O-acetyl-ADP-ribose-deacetylase	gnl\|CDD\|394878	cd02908, Macro_OAADPr_deacetylase, macrodomain, O-acetyl-ADP-ribose (OAADPr) family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family includes eukaryotic macrodomain proteins such as human MacroD1 and MacroD2, and bacterial proteins such as Escherichia coli YmdB; these have been shown to be O-acetyl-ADP-ribose (OAADPr) deacetylases that efficiently catalyze the hydrolysis of OAADPr to produce ADP-ribose and free acetate. OAADPr is a sirtuin reaction product generated from the NAD+-dependent protein deacetylation reactions and has been implicated as a signaling molecule. By acting on mono-ADP-ribosylated substrates, OAADPr deacteylases may reverse cellular ADP-ribosylation.	1.02802e-74
NZ_CP011125.1\|WP_169791443.1\|3335104_3336064_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	1.98852e-25
NZ_CP011125.1\|WP_053232953.1\|3321212_3322127_+\|ROK-family-protein	gnl\|CDD\|236565	PRK09557, PRK09557, fructokinase; Reviewed.	1.22921e-130
NZ_CP011125.1\|WP_053232960.1\|3331534_3332269_-\|carbohydrate-binding-family-9-like-protein	gnl\|CDD\|187678	cd09620, CBM9_like_3, DOMON-like type 9 carbohydrate binding module. Family 9 carbohydrate-binding modules (CBM9) play a role in the microbial degradation of cellulose and hemicellulose (materials found in plants). The domain has previously been called cellulose-binding domain. The polysaccharide binding sites of CBMs with available 3D structure have been found to be either flat surfaces with interactions formed by predominantly aromatic residues (tryptophan and tyrosine), or extended shallow grooves. CBM9 domains found in this uncharacterized heterogeneous subfamily may co-occur with various other domains.	8.62867e-51
NZ_CP011125.1\|WP_053232952.1\|3318845_3321194_+\|hypothetical-protein	gnl\|CDD\|275303	TIGR04510, mod_pep_cyc, putative peptide modification system cyclase. Members of this family show homology to mononucleotidyl cyclases and to tetratricopeptide repeat (TPR) proteins. Members occur in next to two other markers of ribosomal peptide modification systems. One is a dehydrogenase related to SagB proteins from thiazole/oxazole modification systems. The other is the putative precursor, related to the nitrile hydratase-related leader peptide (NHLP) and nitrile hydratase alpha subunit families. These systems occur in many species of Xanthomonas and Stenotrophomonas, among others.	0.00228671
NZ_CP011125.1\|WP_053238806.1\|3322123_3322900_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|226591	COG4106, Tam, Trans-aconitate methyltransferase [General function prediction only].	3.30579e-70
NZ_CP011125.1\|WP_053232967.1\|3338584_3339274_+\|CAP-domain-containing-protein	gnl\|CDD\|131955	TIGR02909, conserved_hypothetical_protein, uncharacterized protein, YkwD family. Members of this protein family represent a subset of those belonging to pfam00188 (SCP-like extracellular protein). Based on currently cuttoffs for this model, all member proteins are found in Bacteria capable of endospore formation. Members include a named but uncharacterized protein, YkwD of Bacillus subtilis. Only the C-terminal region is well-conserved and is included in the seed alignment for this model. Three members of this family have an N-terminal domain homologous to the spore coat assembly protein SafA.	1.88389e-48
NZ_CP011125.1\|WP_053232961.1\|3332813_3333056_-\|acyl-carrier-protein	gnl\|CDD\|376348	pfam00550, PP-binding, Phosphopantetheine attachment site. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of the anguibactin system regulator AngR has the attachment serine replaced by an alanine.	2.00394e-10
NZ_CP011125.1\|WP_053238808.1\|3332255_3332666_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	4.45181e-34
NZ_CP011125.1\|WP_053232963.1\|3333389_3335069_-\|fatty-acyl-AMP-ligase	gnl\|CDD\|341254	cd05931, FAAL, Fatty acyl-AMP ligase (FAAL). FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.	0
NZ_CP011125.1\|WP_083457371.1\|3326437_3327487_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	3.535e-72

>NZ_CP011125.1|WP_053232958.1|3327639_3330051_+|serine/threonine-protein-kinase
MLSRPTARSPLRPGPDETVVPLVVRRRGEDAEARREEGGARMSSVASLASVELSGVLATSPDALRRRLLGPWALGLRQYLALRLGDPQRAGDAFRELRRLVSAMPASELVREPGPKAHVYRLARRIALDLEAQRPVSARGREALAFRDPPDATRGYADALQRVRRSLSGDDAELVELRFARELSPAEIACVVEQPLVDVELRLARATARAFDLLGAHAPDPHATRGGPLVDAFALAKGAQGSATRTAEGESLAALPPGTLIGARYRVVKRVGIGAFGDVYMADDADVPGHRVALKMLREPSLSTAAREAALRELKLIAAVFHPSVVQFKDHGWHEDRLWFVMPWYEGETLDQRMQRGPLARAEARRIFEPLARALAALHANGIRHQDIKPDNVFLARIKGFGPDGEHEESIPVLLDLGVAAKEHEALIGGTPVYFAPEVASHYANVDDERPIGPKADVFALALTLRNALEPDTEEDVPAGAIEAFIERRARERPPLPRAKELRWLAPSFERWLAMDPDQRPSAEELARELAVLTRPEERRARRRAVLQWLVPLLVGLGAAFGALVYVFVRETELQELEISRARTEAQAARADLMVEAARLEALDADHAALLERYEQNRLTRQQLADQLATAEGQIRILGDQIGQLIGDRESLSASLDETREALATMQETFLTQRRQLDTELTRVRDLTRHIDELRIDSERVTAELEGELEQTRGRVEQLEDQLEISRAARREVTARAESLDNQLRESEAARERAMEELVTLRRRVAQLREILDPGEQPARRPQDTGTLDVRAPEGASADPVTP
>NZ_CP011125.1|WP_083457371.1|3326437_3327487_-|serine/threonine-protein-phosphatase
MTTWIIAGVAGLVLAAVLFLLLGRRRDGGAREPAAVGVGAAGLAAGPMPRRRDATGEENGTKLASSPPPGASAHANANSNVGSMEIEISETGLPGEIEEDEPTGPQPRILVTAVGQTDAGRRRKHNEDAYLVLQAHSLFAIADGMGGYAAGEVASQMAIDVITASFETGHFGGSPIPGLPRRGDELVRAIQSANAAILKQARANEAQAGMGTTLVAARFSPNRKRVYIAHVGDSRLYRLRDGELTQLTTDHTLGAMGIQGPSANKLSRAVGVFDEVEVDLNVDEPHNGDYYLLCSDGLSKMVPEDDIAKLIRSTHDDLDAAVRKLISDANERGGKDNVSVILIRVDEPR
>NZ_CP011125.1|WP_157069031.1|3324849_3325932_-|hypothetical-protein
MPTQAEKAVSLVSSIAALLVVTGALAGCGGGGGDDGDDVDAGTRDAQVSGIDGGRRDSGPPVDAMAPPSCEGVSCEPFEYCFEGECAPYPPCAGDGTCRAGSTCHARYCVPDDVDVDGDGSPAGEDCDETDPEKSPLLDEICDGDDEDCDTNVDEGDPAAICEYYPGGGVCIDGSCGCPSGTFDLDRTVPGCECAAMPDLGQGVTCETAIDLGDFPDSPGRTHVVTGNVLPDDRVVWYRFTATDVADTTCDNFHVRAQLMTNPDDTFEITVSRGSCGGVACPGPATPTIDYSWATDFRGDVGGVVSGQCPCWASPTAPSDAAAHCTDDTATFFVRVRRRPGAALSCATYALEISNGMYDS
>NZ_CP011125.1|WP_157069030.1|3324277_3324841_+|hypothetical-protein
MGRSTSRWSAVLGAALVGIAVPCAAHAEDAPEVDPESGHVSVSGGALAGDDAGSLAFRPLVRAEVAFNVAGPLAAGGFLQVAFADGGMSDAPAFGGGVLLTLRPDLPELGFVPHLEITGSRLQLPSRGDGLVDAWSAGIGGGIGVTIVTGVAVEARVHHGWYFGLPATSSLSESAWTFGGALTVDLP
>NZ_CP011125.1|WP_053232955.1|3323693_3324218_-|O-acetyl-ADP-ribose-deacetylase
MAITVERGDITEVEVEAIVNAANETLLGGGGVDGAIHRAAGRELLDACRALPIVEPPRVRCPVGEARITPAFGKLRATWVIHAVGPRYRGVSEDARLLASAFRSSLALAEANEAKSVALPAISCGVFGYPIDAAARIAIGVARERAWRIDAIRFVLFSDDVLRAFQDALAKSAP
>NZ_CP011125.1|WP_053232954.1|3322911_3323577_+|hypothetical-protein
MSFRDDRDALRHRNEALEREVEALRAERDAASEARDRALADAERARKGEIIDAPHSAYRAGEKVIVEWRGSWWDATVVGVVGPREWRIHYDGWSSSWDEDVGPMRILPRGATPPGPRAGKGAGRAVLVLLALLAVAIAAVIVLVRGSDAPASVPGAYTTPGTALAPSDALSVGAPVWVEWNGTWYRATVLQTYDDGSARIHYDGWSDTLDETVARPRMRRP
>NZ_CP011125.1|WP_053238806.1|3322123_3322900_+|methyltransferase-domain-containing-protein
MTSEWRPDLYARFARERAQPFHDLLALVRPRAAMRAVDLGCGTGELTRVLHDTLAAATTLGIDSSETMLAKSAAHLAPGLSFARGSIESFTPDAPLDLIFSNAALHWVDDHPALLARLASFLAPGGQLAVQVPANERHPSHTVAAEVALEPPFRDALAGWTRVSPVLEIADYARALHTLGLVDVHVRRQVHPHVLDTRDAVADWTRGTLLTAYFARLPSELHAPFEARYRELLRARLPDERPFFFPFERVLFRAARSE
>NZ_CP011125.1|WP_053232953.1|3321212_3322127_+|ROK-family-protein
MRIGVDLGGTKIEAIALADDGTIAVRRRVATPAREGYDAIIGAIAELVRTVERDAGCAGASVGVGTPGALSPATGLLRNSNTVCLNGRPLDRDLSVALGRPLRIANDANCFALSEASDGAAAGAEIVFGVILGTGVGGGVVVRGDVLNGRHGVAGEWGHTPLPWPRDDERPGRACYCGRHGCVETWCSGPALAEDHRAHTGERIDGPTIAARADAGDPACVATLARYVDRLARSLAIVIDLVDPDVIVLGGGVGSIAQLYRDLPARLPAWVFSDVVTTRIVPPQHGDSSGVRGAAWLWPIEGAR
>NZ_CP011125.1|WP_053232952.1|3318845_3321194_+|hypothetical-protein
MASTLDEALASFRAGAAPDEVVDAALREADRALESGQALDGIEALVRAESELGAGFGGVRGGGLGVRHVERPRVHALLGFRERVDRTLPALRRAVRFPEDVRRALELEVERAIALSRAFVELGWYAHGASMLAASELPLGYLGARPTQRFEWLRQRASWAFAARELGEARQAVRDYHALVRDGGLPDVEIDRLLDELTGWLEVAPVRTLVAELAPRVAGHPEREGRLLAWDIASTLFFPWDEALEAELESRLREPTVATLEALVDRVGEALAARAALASDPLPRPALLEDGGRVLMLLDRLADLALARDAEKLALRARVTAHEQMLDVLAALRPDALEAMHPVDAARVRELLDEAPWSEAARGARLARLRASITDDADARVIAALVADPLLPPSDAEILSASRLGVDGALVAPDEDTLDLVAALVDRSALCSSGSGGDREIERGTIALARRWLEHAITSEDRALAMEAKEILAGALELEGDLAGALALFEELATYFEARDHERWVRAIERCAMLAKQTGRLAAAGRAARSGFRPGGRVQLPAQDLPEPSDPMQAEEQAERAIAVALRTSDPEVGEAWLRRALALYDRVPDGRRREDEIWERIADLWQAEADALFESGDATSETLDEAHRRAHEALVRAIEVNEDLGDGERVFELSGRVLDVLWTWLTRWEDAIDAFLTLARGRFRSAIARADLDHAAAALFELRAHLADFRSDTSDLEIEGDEGGTFVARFEELEREMADGVAAETEKLGEPWWAERLERRAALLEARWAQLDDDDDGDDEP
>NZ_CP011125.1|WP_053232951.1|3318372_3318795_+|hemerythrin-domain-containing-protein
MRRSDQFRRQHQELQELAVEIGTHLRVEVLEQDASVCRRLVARFAGKLRVHAAMENDALYPELLRHDDPQVRQLAERLVRELGPVYEGFDAYEARWSSAHAISIEPRAFVVSTLETFEMLRRRMATENKQLYPVVDALVR
>NZ_CP011125.1|WP_053232959.1|3330520_3331432_-|hypothetical-protein
MRHVLFLGLTACASTLPAASETAASTQPPAEEAAPPADERTTQARGLRADELLEAAGVATFLEDHELHVAAVDEAAIERWLSRKPSAVFLYTERSLEIAEGASLRGECQRVAVWDDVVVNQLSIVVSRHGDERVVVDLGQESVSVVEQRLEQRRWQASGVRRLPVGVIAWDDAHVAYAEGAEIHELACVPTLRPVPCVEDRWDGPRGHCVDHALVVRPWRAPTVLHVGGVIPGHRDPIPEIPSEECEVTCAPSACDEALRTAHLPRAPLYAEQDPVLAVFRTQTACRAFVASRGPRTPDAATW
>NZ_CP011125.1|WP_053232960.1|3331534_3332269_-|carbohydrate-binding-family-9-like-protein
MRARELVIAASLVASGCTCATPPPRTEIPTLRVPRASAPPTLDGRLDDATWRDAARTERFVDTMDGSHAQPEVTARMAWDDDALYVAFEVDDALLRCDLEGHDAHLWEQDAVELMIDPDGDGRSYAELQVSPTHLVFDTWFDARRVPQPFGHVTWSSELRSAVSTDGTPNDDAADDGWTAEIAIPWSAFERLGTPASRPSRGDTWRIALYVLDVRAQGQLGVGWSPPLVGDFHVPDRFGRVTFE
>NZ_CP011125.1|WP_053238808.1|3332255_3332666_-|acyl-CoA-thioesterase
MPDDRTAVVRHRARVGYVDTDKAGVVHHTVYLVWMEAGRIEYLRARGVDYRRFEVERGLAMPVVEANLAYRSPARFDDEVVIETWVSSVTRARIVFEARVLRDGEVLCEGAITTAVVHLAEARPVSVPEELRDACS
>NZ_CP011125.1|WP_053232961.1|3332813_3333056_-|acyl-carrier-protein
MSDSDLREKLREIIAEVSEVDEIPDETPFKELGIDSMMAIEIVAEVERTFKLSIPEDELKKMTHFTAVYDLVKSKLAAAA
>NZ_CP011125.1|WP_053232962.1|3333100_3333349_-|acyl-carrier-protein
MNRSELIKTFQRMASEIAEKDFSHVTEDAKIAALGIDSLGMLELVGQMERELGVQIPDEQLVGIQTVRQLLDLVEKRAVAAR
>NZ_CP011125.1|WP_053232963.1|3333389_3335069_-|fatty-acyl-AMP-ligase
MTAYPSTLVEALDRLPGGEARGFRFYGADRQERYFPYEAMRAEAHRRAAFLAALGMRKGDCVALVLPENHEFVLSFLGASVGGFVPVPIFPRASFKGADQYVDTLEHIVKASHAKAVICMQQNRDIVDQLRGREGLENLPILDTETGFTGQAPPFAPPVVTPDDLCFLQFTSGSTNRPKGVMVKHHNLVANTTSFLGPHGLARTPDDVGVSWLPLFHDMGLIGFVLGTLIVDLPVVLMPTPTFARMPRMWLELITKHRGTITYAPNFAYQLVTKRCNEKDLAALDLSSLRVAGCGAEPIRARTLIEFAEKFRPAGFKSHALLPSYGMAESCLAITFHQRSTEMIVDRVDGAAMKSGRATPSASPDALELVSCGVPFPGHELAIVDESGQPVGERVVGQILSKGPSVTEGYFENPEASAESFKHGWLWTGDLGYVADGNVYICGRVKDLIILNGANHYPQDLEWAVGEIEGVRRGNVVAFSVMKDGVEQLVIAAEGNSGDAARLRTEIAEAIQKSFGLTPAHVAICAVGALPKTSSGKAQRRKTRAMWESGELEEHPVSA
>NZ_CP011125.1|WP_169791443.1|3335104_3336064_-|alpha/beta-fold-hydrolase
MPHRFMQLSDRFLVGQLQLRGFTSRRVRTSAGHVHVLEAAGRGSLPPLLVLHGFSAAGHLYDGVMLRMRPHARRIVAPDMLGHGLSDMPAAGLCESACRSALLETIDRIVDEPCIVFGNSLGGAAALTLAIDRPEKVRGLFLVAPGGAPMDAAELGAFVDRFRLRTHDEALDFVDRLFAKPHPMRQVLAWGTRKQFGRPGLRDLLERVKPEDLLCPRELGRLRMPIQVVWGAADRILHPTHLDFFRRHLPAHAKLQVVEHYGHTPHMDHPEELHRRLLAFARLVHARTPQREVVTSPGVELSASAERPELPGISASVAP
>NZ_CP011125.1|WP_169791444.1|3336224_3336953_+|hypothetical-protein
MRLRAVSSFVVLASLVWTVAAGWATRADARCAPQGLAPRVLTPVTASLPRDGGGIVVAMVGSSSGENVAMPSGVQLVRGRRTQDLVARELAPGLVRFAAATRLTPGTFSAPALGATSSIAVGRSPLPGVPTRPSVSELRRVAATGMSSRRTPRTEVRATLEFPVPAGIVAIVVAWGEDGAPAAWQPAIEGQREVVVWSEPARCASAPEGTVAPPEGEGASGRIAFVDAYGQVSPFSAAVPLR
>NZ_CP011125.1|WP_169791445.1|3336953_3338504_-|CapA-family-protein
MRALACRAVVLAALVLALAPVRAQDADGPELALGGDVIFDGHITYAIERFFGDAPGPALRELLAETTPALSRADLAIVNLETPVGPRTHERGPEHDAPTFAAPPELLDALAQAGVDALTVANNHAYDQGVAGLASTLEHTARARLPAIGAGRDLDDAARAIVLDARGHRIAIAAFSEGTNRRVRDGDPDAPRIAIASDERIDASVRAARRDADFVVVSLHWTSPLDDRPTRTMQRFARVAADAGADLVYAHGPHQPAPAGRITTSDGRVVPVLWSLGNLVAVMDVDDDRVHAPEPSVRDAIVARVRTRRSDHGRLEVASIASDAYWIATPQRAWWSDPTSAMVRPLSLRAELARIARAACGPRCDRYAASYRARERMLASLLGAETPVESASPELASTTPIARPRSAPRIEHEPPTIPPELARGVALRIEFPHDGAVESSVDRAQIRAIADLLLADRSLRVEIVARPARTERAGIALQRAHRARGLVAILGPSRARFTLRDAPPAATASITLRVSR
>NZ_CP011125.1|WP_053232967.1|3338584_3339274_+|CAP-domain-containing-protein
MSCSRSVAVCAIVLVVVMTGCEGSVDDDRPRVSLDGAMGGADAGPATGDECETLGEIGACNGTTARWCEGGAVREERCADDARVCGVVAGRHRCTDPPPPECGDPIEQEQLRITNEERTRAGLSPLECDPGLTRAARLHSQDMCDQGYFEHDSLDGRTFRDRIDAQGVSWRAIGENIARGQPTPQAVHDAWMDSSGHRANILGEQFGRIGIGHVACGGNGPYWTQDFAD

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Crispr_ID: NZ_CP011125_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_16

3434713-3434809

Orphan

Consensus_repeat	Method
CGCGCGGACGCATGCTCGACGCCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_16

>merge|NZ_CP011125|16|3434713-3434809|CRISPRCasFinder
CGCGCGGACGCATGCTCGACGCCGACGCGCGCCGCGAGGTCGAGGCCGCGCTCGAGCGTGCCCCCGATCACGCGCGCGGACGCATGCTCGCCGCCGA

>NZ_CP011125|16|12|3434713-3434809|CRISPRCasFinder
CGCGCGGACGCATGCTCGACGCCGA	CGCGCGCCGCGAGGTCGAGGCCGCGCTCGAGCGTGCCCCCGATCACG
CGCGCGGACGCATGCTCGCCGCCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053233052.1\|3433401_3434034_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213871
NZ_CP011125.1\|WP_053233057.1\|3440194_3441151_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233049.1\|3430647_3431427_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP011125.1\|WP_075097521.1\|3437166_3438372_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP011125.1\|WP_053233062.1\|3448863_3449226_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233047.1\|3428296_3429025_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP011125.1\|WP_157069042.1\|3441211_3442135_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376792
NZ_CP011125.1\|WP_053233046.1\|3427003_3428269_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|223513
NZ_CP011125.1\|WP_075097520.1\|3431471_3432485_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP011125.1\|WP_053233051.1\|3432481_3433402_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223687
NZ_CP011125.1\|WP_053233045.1\|3425587_3426967_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233043.1\|3424233_3425049_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375319
NZ_CP011125.1\|WP_083457388.1\|3442365_3444168_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053233054.1\|3435638_3437060_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233056.1\|3438368_3439361_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132002
NZ_CP011125.1\|WP_053233048.1\|3429021_3429858_-\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NZ_CP011125.1\|WP_157069041.1\|3425151_3425478_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_083457389.1\|3446110_3448672_+\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|234827
NZ_CP011125.1\|WP_157069043.1\|3444248_3445868_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214621
NZ_CP011125.1\|WP_053233064.1\|3450453_3451698_+\|DUF4388-domain-containing-protein	unknown	unknown	gnl\|CDD\|373017

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053233052.1\|3433401_3434034_-\|hypothetical-protein	gnl\|CDD\|213871	TIGR03840, TMPT_Se_Te, thiopurine S-methyltransferase, Se/Te detoxification family. Members of this family are thiopurine S-methyltransferase from a branch in which at least some member proteins can perform selenium methylation as a means to detoxify selenium, or perform a related detoxification of tellurium. Note that the EC number definition does not specify a particular thiopurine, but rather represents a class of activity.	2.36798e-76
NZ_CP011125.1\|WP_157069043.1\|3444248_3445868_-\|hypothetical-protein	gnl\|CDD\|214621	smart00327, VWA, von Willebrand factor (vWF) type A domain. VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.	1.58833e-05
NZ_CP011125.1\|WP_053233049.1\|3430647_3431427_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.4351e-93
NZ_CP011125.1\|WP_053233047.1\|3428296_3429025_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.22215e-58
NZ_CP011125.1\|WP_053233046.1\|3427003_3428269_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|223513	COG0436, COG0436, Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism].	1.14289e-58
NZ_CP011125.1\|WP_075097520.1\|3431471_3432485_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	2.63853e-74
NZ_CP011125.1\|WP_053233051.1\|3432481_3433402_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223687	COG0614, FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism].	8.27439e-38
NZ_CP011125.1\|WP_075097521.1\|3437166_3438372_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	8.69592e-63
NZ_CP011125.1\|WP_053233043.1\|3424233_3425049_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	3.10523e-25
NZ_CP011125.1\|WP_083457388.1\|3442365_3444168_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.71739e-97
NZ_CP011125.1\|WP_157069042.1\|3441211_3442135_-\|hypothetical-protein	gnl\|CDD\|376792	pfam02472, ExbD, Biopolymer transport protein ExbD/TolR. This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.	5.65612e-06
NZ_CP011125.1\|WP_053233056.1\|3438368_3439361_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	7.02384e-102
NZ_CP011125.1\|WP_053233048.1\|3429021_3429858_-\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	2.88938e-29
NZ_CP011125.1\|WP_083457389.1\|3446110_3448672_+\|sodium-translocating-pyrophosphatase	gnl\|CDD\|234827	PRK00733, hppA, membrane-bound proton-translocating pyrophosphatase; Validated.	0
NZ_CP011125.1\|WP_053233064.1\|3450453_3451698_+\|DUF4388-domain-containing-protein	gnl\|CDD\|373017	pfam14332, DUF4388, Domain of unknown function (DUF4388). This domain family is found in bacteria, and is typically between 102 and 135 amino acids in length.	7.63864e-08

>NZ_CP011125.1|WP_053233052.1|3433401_3434034_-|hypothetical-protein
MDPDFWRTRWAEGRIGWHQGAPSPHLVSHARVLEGAGRVLVPLCGKSVDLAWIAARPGGPSVVGVELVEEAARAFFEEQSIPVHRTHDGPFVRYEGSTIEIVVGDIFEITTAEIGRFEACFDRAAMVAMPPSMRGAYVAQLRSLLEPGARVLLVALEHDAPDGPPFSLREDEVRALYAGAKVTRLGAIETETSAALAARGAREVAYEIEI
>NZ_CP011125.1|WP_053233051.1|3432481_3433402_-|ABC-transporter-substrate-binding-protein
MRDFATPIACALALAASATLGALAPESTWAPQPVAPPARPARIVSLTLPADEIVLALVSPERVLALEAYVDDAQASNVVDEARAVRGRMHQPITAEAVIAARPDLVLLSGWSDPQLEALLGVQGVPVERVLSAQSLEGTRAQITRIGELLDERQRAREVIAAMDARIDAVRARGAARTWRPRVLLFSWSGHTPAEGTLFCELVDLAGGSCASTEAGLSGYAPLTIEHLLELDPDVIVTNRYRADGRARAVVPEPALEDDPRLRTLRAVREDRVVALPSAHLLATSHHVASLAEDLSRALDALEPAR
>NZ_CP011125.1|WP_075097520.1|3431471_3432485_-|iron-ABC-transporter-permease
MRRVLPASIVALALIALAIPLATAIGPSTLAVDRVLAVLLGMARDVAPWERAVVLDVRLPRVVVALLGGAALGISGAAMQGLFRNSLAEPGVLGVSGGATLGAIVALYAGAALPLVVVPGAAFAGALGCALVVYRLASAGGRARTASLLLAGVAVSGVATALASMVLSIAVADWELGRQMLSWMMGGLEGRSWTHAAIVAPPIVVGGGLLFARARELDALALGEESAAGLGVDVPALRRAVLMLVALATGATVAVMGAIAFLGLMAPHVVRLIVGPAHRRVLVGSAVAGGLGLVAADALCRAVAGSVDLRPGVVTAILGGPFFLWLLVRDRAAGGEA
>NZ_CP011125.1|WP_053233049.1|3430647_3431427_-|ABC-transporter-ATP-binding-protein
MSARLELDHVEAGYRGRAVLREVSLALSPGEVVGLVGPNGAGKSTLLRVASGALAPRAGAVRLEGASMAAMSRRDVARRLAWLPQAQSTDLAFRAREVVAMGRLPHLGPYAPAGAHDRAAVDAAIAATGIEPLAERSFPTLSEGEKQRVLLARCLAQEPGVLLLDEPTAALDVRHAWSLMRVVRERASAGIAVLAAIHDLALAARTCDRVIVIAAGRVARDGRPEDALDAAVIAETFGMRARVQREEAGIAITILGPSG
>NZ_CP011125.1|WP_053233048.1|3429021_3429858_-|dihydroneopterin-aldolase
MPRFRARSAPPDVIAIDGLQVNCVVGVYPHERHEPQPLRVDLKLMLDTAVAGETQRLRMTVDYAMIASQLAFLLQSCRFHLLETAAHALTRYLLAPPALGEDRPRVQGVTLRLTKPNALGGHGIPSLEVHRVPADVRLRHETKPWGTVDVVHETKTEGIYRLNVAPGQHIPLHAHHVMQESEMALGDGLVLSGKRIPAGQVHRWPHGKKHLWENPSDRWQSILCVDSPPFLPHDEQLAEGTPDEVAPEPPFLPLHSVEAPSGVEAPSGVEAPSGVVPT
>NZ_CP011125.1|WP_053233047.1|3428296_3429025_-|SDR-family-oxidoreductase
MRAVESVIVTGASRGIGRATAERLIASGRRVAAVARDARALDALVAGSGGRAVAIDADLASPDALRTVVPRAIEALGDVDALVSCAGIAKHRPLAAIDEALFDEHVALNVRAPLFLSRDLARHLDARDASGAIVHLASTLALQGVAGTSVYAATKGAIVALARTLAIELAPRVRVSCIAPGAVDTEMIRAPRSEESLRELAALHPVGRIGTADEIAEAAEYLLEARFATGTLLVLDGGLTAA
>NZ_CP011125.1|WP_053233046.1|3427003_3428269_-|pyridoxal-phosphate-dependent-aminotransferase
MSSTHDGSPRLNAFRPVPRTGVIYVTAEATRRGYRQDDPDWCNLGQGQPETGPLPGAPARVTHVDIDPADQEYSPVPGLWELRETVASLYNKLYRRGLPSQYSAENVAIGGGGRVSVMRACAAVGGVHMGHFLPDYTAYEELLDVFRRFTPIPILLDPETGYDFSVRQLRREILGRGLGALLLSNPCNPTGKVIAGEELRAWVTLARELDCAMLMDEFYSHYVWKDGVTMSSAAQYVEDVDHDPIVLFDGLTKNWRYPGWRICWTVGPKSVIQAMSSAGSFLDGGPSRPMQRAAIALLDEEGTRAETDAIHTSFLAKRKVLLQGLRRLGVRFDLEPEGTFYCWGDVSGLPASLRTGEQFFQAALERRIITVPGVFFDVDPGKRRGGRPSRFQHHVRFSFGPSMPTLERALVRLGEMIAEAT
>NZ_CP011125.1|WP_053233045.1|3425587_3426967_-|hypothetical-protein
MALRFALAAAVVLCTACCVNPVDPSPVPPPTGPCGARPCLDAGGPVFRDGGETFPGACFIPGFAQPCERECAHSQLTCFRERRTTTDVEHEGGTATLEVVAFPNGLCSTACSVDAECGDCGQCVPYALAGRARLQGIVGGTGVCRPRCFGLECGAGYACDPLVGACLEACTTDEQCRFSTVDTDGDGDDDALAYDAESTLVCASGVCTADAVSIGPACFEGIECPAGFECLRDPERMRTGMCGRVGCSTDESCGPDAACVEREDGTTICTQACTVGAERPEDRIGGTGRGAGCAERFACLHHGPAATDGACLPGTYDDVLEPNVGERCSADWECYSPYGRGRCLRARPDEGEGTCVVEDCIAGQADQLWPGVTVPSPTICDQTAATCLPITATRSRTLCAVTCASASDCLPGWACVALPGGDRACFPGCTVDEDCRSGTTCRADDDTPCDDADRGCVCE
>NZ_CP011125.1|WP_157069041.1|3425151_3425478_+|hypothetical-protein
MNVRMIVPLLVLVPFALFSGMVVLEEGYLGFFSVAREEPWGMQMLIDLAICFVLVLRGLAKDARERGLALWPWVIGTVLFGSIAPLGYLVYRELVARPAPLAHAVAQK
>NZ_CP011125.1|WP_053233043.1|3424233_3425049_-|helix-turn-helix-transcriptional-regulator
MDLAHARFGPMLKRFRGSRGLSQERLAEHAEVSPRHVSFLENGRAAPSREMVLVLASALDLPLRERNTLLVAAGFAPVYASSPIESATLEPVRRALDHLLRAHEPFGALVVDRDWNVVRMNAGATRLLGWALEGLTPPPEALANLLVAIFHPEALRPRIANFEEIASAMIERVEHELQLETDDARRARMTSLLGSLHDAPRGSAPSAGPALPFLPVRLRRGDRELRLFTTLTTLGTPLDVTAQELRIESYFPADADTERALRDLAGETFSA
>NZ_CP011125.1|WP_053233054.1|3435638_3437060_-|hypothetical-protein
MRGRFARLLIVSVLVSGCSTIVDPDEGRLDPPAGSDGGGGVLDAGGVDAGDEPGVDAGPPPIDGGGGECVPSCVGSTLTRCEGGRPVVEACALPCATEGVRCGEMIPSNVGAELWTTEARDVVVAGTARFDTSACTSTMSLARVVPQSAGPSVCVLQVRNLRVESGATLSVVGNLPLAILATGDVEIRGTLDASAALERPGPGGGAGGRPGAIDGSGWGPGRGGTRMGSFDDGGGGGGGLCGSGGAGGAGGDAAGGAAGPATDAQLLVPLRGGSGGGLGLGATGGGPGATGTFGLGGGGGGGVQISALGRIRVEGAILVGGGGGRAGRSVEAGNWGAGGGGGSGGGILLEAPEVAFEGSGTLGATGGGGGGSASAGTSGGDGEDGRVSLTSASGGASGGPEYGASGGDSGGGEVLAGRAGEANEARSANGGGGGGGAGCIVVRTADGTLPPGVEDGWSPGGAGGVFVAPVLVR
>NZ_CP011125.1|WP_075097521.1|3437166_3438372_+|FAD-dependent-oxidoreductase
METKPRVIVVGGGYAGVMAALRASRRLRHRGEVVLISDRDAMIERVRLHEAASGTVDPARPLATLLRGTRVRIVRGRVESVDRAGHEVTLSSGERMRFDRLIVAIGSRVDASAIPGAAEHAFTLEPDAVAELEVAARDAAQREGHLVVIGGGLTGIEGATELAERHRGLRVTLVTSGEVGPGLHPRAVEHLRRVFARLGVTLREHARVERVEAGAVVIAGERLPFDVCVGAVGFAIPGSLRAWGFPVDARGRARVDAMLRLEGAPDVYVAGDCAAPSGVLGSAVPFGCKSAMPMGVHAAENAVRSLGGEPEHALDWSDATYCISLGRREGLVQLMDPRGTPRTTFLSGRLGAIVKEMICRYTVRSVELERDGWWEFRFPRVRLHALPARDPERLAAPPEAA
>NZ_CP011125.1|WP_053233056.1|3438368_3439361_+|sigma-70-family-RNA-polymerase-sigma-factor
MKNDPAALYSEHRSFLIGLAYRMLGSVAEAEDAVQEAFVRAQGAPSSPFNDAANAAESASADAERGGDRGGVGRAATNDRASRADVASPRAWLATVVTRICLDQLRSARARREQYTGEWLPEPVRTDVAGAVVQPRDPEDAESLSLAFLLLLERLSPLERAVFLLHEVFDYSHAEVAAILERDEVAVRQLMSRARAHVKEGRPRFPADPDRHRELVMRFAMAIGEGDLGGLQAMLAKDVVARSDGGGRAKAARRAVQGDDRVARFVVGLARKASADVRFELMEINGRTGIAWSIAGRPLGVMAVTIDGDRIVEIDLVINPEKLSGISARE
>NZ_CP011125.1|WP_053233057.1|3440194_3441151_+|hypothetical-protein
MAAAKKRSKKATPIKKAATTRRTAAKGRVGLDTSRAWSLDEIERELTPVSAARVAAVRDAIVRAYGDDKLVELGTGFRTEEIVAVAPNVVAAALLAVRKLGRAPQGLALELLTLAVSEARELARLDLAHEQQLRDVASEIAGRREALKTSRATALRERRAVATHLLRNVLPRDAPQRAELERAAGKAATASSVVASVRTVARILADARRDESLVVVLDSYGYDDALVARLEALAAETERLSGTSATLTPPQAVDQRTLDRHDGLVLAILRAIVSALRDAQRAGAPISLPPLAGLERLLVPSRDDEQDDEEPEPVAPAS
>NZ_CP011125.1|WP_157069042.1|3441211_3442135_-|hypothetical-protein
MELPISLRGDPTAPSDALRVEISPTELRLESRPVYTLERGRVPAAEVTPDGLTQLRTALQAAPARPRVALTAHGMVPYGTLVRTIQTLTAAGYRDILLAVRPVSTTGAAPTAPSWMPLSSPQIAPFGPEPVDPATYGGPARGWGDFTSRWEESYDACRAAGPGQYVDCDPKASVTPEDGQMQVVLWARGRGMQVRFNRVGAPPPEPSKAPSGPALIEGVRAAPTGEGEEIPPDPSTTGAFAFRAEVATAADSAISGVTRPVCGAAACPTVVEADEETPVMRVVSLLGAAFPNGATPPHLVLRMPAAR
>NZ_CP011125.1|WP_083457388.1|3442365_3444168_-|serine/threonine-protein-kinase
MSRPAPSEAPLVSAADSFVGRVLEQRYRVEQRLGEGGLGTVYRAQHLKLARNVAVKVLRDDLRGIPQLRARFEREVKALSSLSHPNVVTITDYGVEGGMPFLVMELVEGVELAKIVGEPLPPERALMIVRQILASLAYAHERDVVHRDLKPANVIVRQLPDGRDHVTVLDFGLAKFVGDDPGGDLTRSGLVVGTPAYMPPEQMAAGARRADARSDLYAAGLILFELIAGRRPFTFEEPAELLRAHLVMQPPTLAEALPGSVVRPELEELVARALAKSPDDRFPDARAMIDAMDALPYEPLVRGGVGGHDARRDTTRPARPTPISAAAAASERPAPTPTAAERARSMGMRAGIAAIVFLMTIAGIAWTARRATTEPVADAPTTEPAPPAAPLARSEGPGTIATQPTAPVAAAEVTPRDHDPVAAGAEDTEALVGEEDEGEVAPEVEAPFVAPVRVGPRPPARNPLRGRLPGVLSRVDARIERGRPIGAGDIRALQRYRNDRPGDVRGRLVLGHAYAARGWLSPAMDQYERAVGVDESVRGDPAILENLLRAVRTESLNARASELVVRIFGAEAQAGVRRAISRVRDPGERGRLEALSARLR
>NZ_CP011125.1|WP_157069043.1|3444248_3445868_-|hypothetical-protein
MRRGVWWGIAVVVATIAVGCGESHPPGDDGGADDFDAGEHDASTVPGQDAGTIPDDDAGAPGDDASPPDLDAGPPESCDSPGVVEDVPCGNCGTVSRFCTASRVWEYAECEGEGVCAPGTIDAVECGNCGTQTARCTTACVWERTGGCTAEGECAPGTRTRSSETCTAPQTREFLCNDACTFEPASECSADACPTPGMLQEVPCGMCGTRERFCTSARVWEYGPCGGEGVCMPGTTGPVACGNCGTRTARCNTSCEWDGSGTCTGEGVCAPGTVTRSGALCPPMQTQRVQCTDSCTYTPLDACRGTVPVDVMVLLDVTGSHATYVRDNVANFGTRLVAPLLAIDDVAVGVAWYADFPIDPFGVTGDRPFEGGVQPTRTRAEIDAAFAAAPQRNGNDLPESAVEALSILAGGTPPASAIPLACSTGRTAGGCWRSGVRRVIVVYTDASSHNGPSPTSTALHSPYTTIPTAATWPAVRSRLMTDGTLLLVLYRSNSDGDAPGQYDEMLRDLGQPASDRIAADTLTTALDAVVARVRSIAMP
>NZ_CP011125.1|WP_083457389.1|3446110_3448672_+|sodium-translocating-pyrophosphatase
MSSRLSSLLARVAAAAAALAAFAAPSLALAQETGHAAGGEANLRLPDFSTVTMLGIDGRTLLMSGLAVCALGLAFGFVIFNQLKAMPVHKTMLDISELIYETCKTYLITQGRFIMILFAFIGAIMVVYYGVFAFAHLPAGERWMRVGMILVFALIGVAGSYGVAWYGIRVNTFANSRTAFASLQGKGHPVYAIPLKAGMSIGMMLISVELMMMLLILVFVPGEFAGPCFVGFAIGESLGASALRIAGGIFTKIADIGSDLMKIVFKIKEDDARNPGVIADCTGDNAGDSVGPSADGFETYGVTGVALISFILLVLTSPEAAEAQKMLLVWLFMIRVVMVVASAASYLVNEAIAKSRYGNLGKFNFEHPLTVLVWLTSIVSILATFGVSAALIPELGGASSAWWKLSVIVSCGTLAGAIIPELIKVFTSVESGHVREVVTASKEGGASLNVLAGLTAGNFSAYWMGIVFVVLMGVAYGVTMMDAGTSEALGAIIRFQTEGGWVDVSPIFAFGLVAFGFLGMGPVTIAVDSYGPVTDNAQSVYELSLIENVPNVKEEIKKDFKFDANFEVAKELLEENDGAGNTFKATAKPVLIGTAVVGATTMIFSIIVLLTGLRPELLTHLSLMHPPFLLGMLAGGSVIFWFTGASTQAVSTGAYRAVEFIKANIKLEGVEKASIEDSKKVVEICTVYAQKGMFNIFLTVFFSTLAFAFLESYFFIGYLVAIALFGLFQALFLANAGGAWDNAKKVVETELKAKGTDLHAACVVGDTVGDPFKDTSSVAMNPVIKFTTLFGLLAVELAEILQGSVDNGATMRVVIAAVLFAISAFFVYRSFYGMRIAALEGESHAKTAAAPAE
>NZ_CP011125.1|WP_053233062.1|3448863_3449226_-|hypothetical-protein
MRFVLVAIPAALGLSACGACACLPCPPPITIDVHLDDTHDASSVSVAGFACVAADAPQTVTCTSPQIGGGTHGLVVHVGERSIPIRVHVPGEGGGSCCGCGYLPVREQVLVLGDPRMSGV
>NZ_CP011125.1|WP_053233064.1|3450453_3451698_+|DUF4388-domain-containing-protein
MAEPNDLVIVEADGSVRVPGRGADRRLRDRAGRYRLVVDATGLIVLRAEKSDGAAQPRVLMAGEIVSRTSILELVNIIASASWRGDMHIFGPDAHRVLSIDQAALKSATSTHPDDRLGQVLYRNGILSKQQLDEILAEVDPERRFGQIVVDKGSISQEQLFEQLQKQVEQIFFASLLIREGHYVFVQPDEGAEAPVHPVHLPVQALLMEGVQRIDEMALFRERIPHDELVPEVQPRVSVHSLEETAQTVLAWADGNRTIEDIARETGLGQFMTVKALYGLLQQNLVVLRPKKSVDSTAVRKVVSQFNDVLRDIFMAVATYGGVDQTRSTLEAWIVGSGYGPIFGEHVEEDGSIDPAVVARALADIKVDNPMEGLHQALHELAAFALFAATTSLPRDQELMLSRDVTTRLKRIRM

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Crispr_ID: NZ_CP011125_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_18

3669761-3669834

Orphan

Consensus_repeat	Method
GACGCGGGCTCGTTCGACGCGGGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_18

>merge|NZ_CP011125|18|3669761-3669834|CRISPRCasFinder
GACGCGGGGACGCGTGATGCCGGTCCGCGGCCCGACGCCGGGATGCGCGACGCGGGCGCGCGCGACGCCGGTCC

>NZ_CP011125|18|14|3669761-3669834|CRISPRCasFinder
GACGCGGGGACGCGTGATGCCGGTCC	GCGGCCCGACGCCGGGATGCGC
GACGCGGGCGCGCGCGACGCCGGTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_169791458.1\|3659033_3659891_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238017
NZ_CP011125.1\|WP_083457408.1\|3662377_3664456_-\|beta-galactosidase	unknown	unknown	gnl\|CDD\|366567
NZ_CP011125.1\|WP_075097527.1\|3678913_3681307_-\|polyphosphate-kinase-1	unknown	unknown	gnl\|CDD\|235469
NZ_CP011125.1\|WP_053233230.1\|3667310_3668252_+\|prolyl-aminopeptidase	unknown	unknown	gnl\|CDD\|130316
NZ_CP011125.1\|WP_053233228.1\|3664918_3665611_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP011125.1\|WP_053233224.1\|3659887_3661291_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053233235.1\|3671666_3672884_-\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234752
NZ_CP011125.1\|WP_053233231.1\|3668276_3669284_-\|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|234629
NZ_CP011125.1\|WP_053233237.1\|3673798_3676216_-\|endopeptidase-La	unknown	unknown	gnl\|CDD\|223542
NZ_CP011125.1\|WP_053233240.1\|3681380_3683072_-\|family-1-glycosylhydrolase	unknown	unknown	gnl\|CDD\|274539
NZ_CP011125.1\|WP_157069067.1\|3678292_3678904_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233238.1\|3676435_3677197_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382
NZ_CP011125.1\|WP_053233241.1\|3683119_3683428_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP011125.1\|WP_053233239.1\|3677264_3678287_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366285
NZ_CP011125.1\|WP_169791457.1\|3658215_3658950_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233236.1\|3673123_3673711_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233229.1\|3665691_3667311_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP011125.1\|WP_053233234.1\|3670517_3671510_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP011125.1\|WP_053233227.1\|3664510_3664900_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|129116
NZ_CP011125.1\|WP_053233225.1\|3661298_3662381_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_169791458.1\|3659033_3659891_+\|FHA-domain-containing-protein	gnl\|CDD\|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	1.65045e-17
NZ_CP011125.1\|WP_083457408.1\|3662377_3664456_-\|beta-galactosidase	gnl\|CDD\|366567	pfam01301, Glyco_hydro_35, Glycosyl hydrolases family 35.	1.08313e-33
NZ_CP011125.1\|WP_075097527.1\|3678913_3681307_-\|polyphosphate-kinase-1	gnl\|CDD\|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NZ_CP011125.1\|WP_053233230.1\|3667310_3668252_+\|prolyl-aminopeptidase	gnl\|CDD\|130316	TIGR01249, Putative_proline_iminopeptidase, proline iminopeptidase, Neisseria-type subfamily. This model represents one of two related families of proline iminopeptidase in the alpha/beta fold hydrolase family. The fine specificities of the various members, including both the range of short peptides from which proline can be removed and whether other amino acids such as alanine can be also removed, may vary among members.	5.74447e-95
NZ_CP011125.1\|WP_053233228.1\|3664918_3665611_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.58788e-84
NZ_CP011125.1\|WP_053233224.1\|3659887_3661291_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.64896e-101
NZ_CP011125.1\|WP_053233235.1\|3671666_3672884_-\|threonine--tRNA-ligase	gnl\|CDD\|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
NZ_CP011125.1\|WP_053233231.1\|3668276_3669284_-\|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	gnl\|CDD\|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	7.77458e-180
NZ_CP011125.1\|WP_053233237.1\|3673798_3676216_-\|endopeptidase-La	gnl\|CDD\|223542	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP011125.1\|WP_053233240.1\|3681380_3683072_-\|family-1-glycosylhydrolase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	1.67435e-58
NZ_CP011125.1\|WP_053233241.1\|3683119_3683428_-\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	9.60346e-06
NZ_CP011125.1\|WP_053233238.1\|3676435_3677197_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	9.32388e-26
NZ_CP011125.1\|WP_053233229.1\|3665691_3667311_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.37749e-55
NZ_CP011125.1\|WP_053233234.1\|3670517_3671510_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.78241e-58
NZ_CP011125.1\|WP_053233227.1\|3664510_3664900_-\|RidA-family-protein	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	1.02478e-55
NZ_CP011125.1\|WP_053233239.1\|3677264_3678287_+\|hypothetical-protein	gnl\|CDD\|366285	pfam00754, F5_F8_type_C, F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.	0.00378335

>NZ_CP011125.1|WP_053233231.1|3668276_3669284_-|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase
MTHTIAVLGAGAWGTALAKALSDKGHQVHLWSWQKPHADAIQRDRTNQDFLPGFELAPTLRATSDLPDALGGADMVLTAVPTHVLREVLGKAAPHLPESAPILSVSKGIEISTLKVVSGIFEDCVPKETLDRVAYLGGPSFAKEVAAGMPTAVVVACTSHDVACRWQEALATDRLRVYTTDDVIGIELGGALKNVIAIAAGVSDGLGFGHNSRAALITRGLAEMTRLATKMGAHPLTLAGLGGMGDLVLTCTGDLSRNRTVGLELGKGRKLDDILAGMTQVAEGVRTTKAAYALAQREGCEMPITDAMYRILYEGQSPLEATVELMTRRKRAERD
>NZ_CP011125.1|WP_053233230.1|3667310_3668252_+|prolyl-aminopeptidase
MFPPIEPFATGRLRTRDGHEIHWETSGNPRGKPALYLHGGPGAGLMTGHRRRFDPERWLVVALDQRGCGRSTPLVIDALDTLATNTTDALIADIEALREHLGIDAWLVYGVSWGTTLALAYAQAHPARVTELVLMCVVQTSASEVAWITEDLRRVFPREWSRFEAASKRRSGQRVIDAYHALITSADATEREEAARAWCAWEDTHVSLDPRHRPEPRFETDAVFRQTFATLTIHYWKHAAFLEDGALLSRIDRIAHIPAALIHGRLDISSPLEWPWQLHLAWPKSTLTIVDDEGHGGDTMIDEVVRAIARFAP
>NZ_CP011125.1|WP_053233229.1|3665691_3667311_+|HAMP-domain-containing-histidine-kinase
MEWRSRLVYLALIPAIAIAAGILGYFSIQSARQFARESEQSVLASTLVLVDEKVDRVEQMIITSDEAVFHLVDLERPEAVSETWQPLAERISPSVRALLVLDDGGEVIGYACRCSTQERRDFLKVFTERILPNLELERERIGVLRHHHRTYADTSYLISYRAVRHAGRRHYMVAHHDTGFIEREVFPTLFVHEEERVSYNVVDDDNRLVYGQSRIARAGDYLVGRRFPTTLYGWRLQIAPKRAPELIVRGAEQVYTESALIGLSFAIVLLGVGFLIYAAVKESRLNALRSEFIANVSHELKTPLSVVRMFSEMLMTGRVRDEKKREQYLQIIARESERLTALIDNVLDFSAIERGKQTYQMREGDLADVVARAIDTFRYRLERENLEVKLEVVGEVPAVRFDEQAILLAVMNLLDNAMKYGAGSTIEVTIERGRRHAYVRVRDHGPGIPDEHHKRVFERFYRVRNGSSSARGSGIGLSLVKRIVEAHRGRAWVENAAGGGARVSFSLPFSDLAGGGTAVALSSWRNDAGPPPDDEIAER
>NZ_CP011125.1|WP_053233228.1|3664918_3665611_-|response-regulator-transcription-factor
MATPERRILLVEDDPAIALGLVDSLEFEGFAVTHARTGQEGIQLARSEHPDCIILDLMLPDTNGYRVCEQIRAHDTLVPILMLTARSQEADKIRGLDAGADDYVTKPFSVGELVARIRAIFRRTTRAQITEAPIRIGTASIDPAAQTMKRGRETTSLSFYEVQLLKYLFERAGQVVSREELLDKVWGVEGTPTNRTIDNFIVKLRKKIEPNPEKPAHILTVYGLGYKLVV
>NZ_CP011125.1|WP_053233227.1|3664510_3664900_-|RidA-family-protein
MAKRDVLSSEHAPKAIGPYSQGIRCGQMVFFSGQIPLDANGEFVGQGDVRAQIEQVMKNVDALLKSAGLGFDDVVKATIFLVDLADFATVNEVYAKRFEGIAPPARSTVQVAALPRGARVEVEIIAIAG
>NZ_CP011125.1|WP_083457408.1|3662377_3664456_-|beta-galactosidase
MKPKRPAARPATRARAVRRVGGVRLEDGALRIADRSVPLLCGAVHYWRLERESWRAALSETRALGIPIVETYVPWQVHELAPGDYDFGQRDPRKDVGAFLDLAADLGLYAFVRPGPHINSEMTWFGLPERIVYDKSIQARSPKQSPVVLGFPPRMFPVPSYASEQYHLESQRWLEAAAAQLAPRLWPQGPIVLLQVDNEATYWFRDSAYDQDYHPDAIAGWRAWLAQRYGTPYEAGRAHRREYAAWDDVVAPERFDAETPEQLALHLDWGAWREELITRALVRFKGAMATAGLKGVPTVHNLPLGEQAAPVSTPRIEEIVDLVGLDYYHARREHRTIKRRTLFLAGSSRLPFAPEMGVGAPPWFTPLTHEDSLFCAMSACAYGLRGMSLYMTVDRDRWYGAPIDATGNPRLEAGAWKSFLHALTSIGFHRLQRRVEVGLALPREYSRLSRATHLMGVLSPITLEAIGGSPVEACSEEPLGFAGPIQVLWWTMIARFAEALTAAGVPYVYVDGDAPEERYDGLRVVIAPTYEFASVARWSRLCDFASEGGTVVFGPAMPTLDDTMRARPFEVPRHGRKVLIDRPEDADEVVRTLVHDLGLETPFRASPAPVETTVHEDEGGPRVLFVINPAPERIEAIVELPYAIAFEDSASGDRFAGDRSITVPMAPHACRMLVVRRSAQEEGAQATAGRVS
>NZ_CP011125.1|WP_053233225.1|3661298_3662381_-|hypothetical-protein
MIAADLRVEGFDARSWTNLISLFAPGVVTRIQREPAPSDAPELDTKEAEDAGLSEQRSTGSLVIVISETGRVRKAFHSQRGRIRDLAQASPSELPMITERYRARRALLMREGAIEEIAERVAVRLERGDDYVAQWLVVARTIREVIDAGMIHVWPRPLAGVPIPTAGMVRRALDTVLPDDRALVMVIWSGSTPWTGVVLRRRRGEIDLVAGPDLIARWSGPLGGDWRRDHRFVSEGIARAVAPVHLGIYAEIGSIRRLLRSAEPGAWARAVAVRDVIVSPTPPYVAVAIGADAARAVAQRTTTWLGGIDALASLAPAVTYVRGRISEIASVTQTLGFDPLKLLAGSLARSEDGDEKNDER
>NZ_CP011125.1|WP_053233224.1|3659887_3661291_+|serine/threonine-protein-kinase
MTRSTIHAIRPSEVERAPVGVPGVILGGKYRLDEAIARGGMARVWRATHVTLNRPVAVKFVDAWGATPEERNERFLREAKVAASVRHRHVVDIIDFGTSRNGEPYMVMELLEGETLDQRLGRGPVPVDEVIEIAAQLLSGLDAVHRAGIVHRDLKPGNVFLTHDEVDGVFARLLDFGISQGADEIATESDRVVVGTPEYMSPEQAFGEPLDARSDLYAVGVVLYEMLSGVLPFEDPDPQKVVELVAHGTPAPLLSMRPDIPEICAVIARAMSPMPEARFDSAREMRRALLDAVGRGPDVTGRSSAVPRDSRVSGLQARAVATVAASGVTRSGETLAETLAPPEGPRARTRWTVMAVVLLVVVGAGAMWLAMQGGEERAAGDDAPPSAAMQAAEPSPSTAVPSTGPEEAAAAAEGDDGEASEAESTDEALPERSTRRPRRRARRATRDGEEPDPSTPSEPTIRRELDF
>NZ_CP011125.1|WP_169791458.1|3659033_3659891_+|FHA-domain-containing-protein
MPNGVSPRFRSSLVAIRLQDRVMARFRLRLQDREIALPAGGELVVGRDATVADVALDDRLVSRRHAAFRCHGDDELEIVDLESLNGVRVNDVPVKGVRALGHRDRVQIGAHVFLVVDQRREHRSNAPTTRGSMRTASATRPTPRAQRAIVTPLDTIAQALADDDLSAAVVAMDAVIARYGDPSEALMPGELGRVVELLLALSERTGDMRFFDRVFQIHTGRRLVIDGASIDAIQNALPHLERASSQGLDTYLAAMGARGATLSPQEQVRLRRIAALTRRVGKGKA
>NZ_CP011125.1|WP_169791457.1|3658215_3658950_-|hypothetical-protein
MRDTAAARALFQEGVACADRSDWTCAADRFARAHELRASAVIAYNLGHALVESGRLVEGTEILRRLVRDESVAANVRADAARVIRDAEPRIGRLAVHLRGPHEDVEVALGTHELASSLLGTAAPVDPGEHVLEARRDGEIVASARVHIDPGATEEIELEIPARPARATASAIAPEAAAQTAFDATGARDVAPSEGGDDGTWIALGVAGGVLVVAAAVVVGVVLAAPAQEPAPFDGTLGWVEIGR
>NZ_CP011125.1|WP_053233234.1|3670517_3671510_-|diguanylate-cyclase
MLGGGQDALHVLLDLTRRLAEPIELEAQLQATTDAALAILPGDHASLRLFDEGKSELLSSARSGTGVTQPPATFRRGQGVVGAVAESGRSTLVPDALEDPRFVAYPTQGFEVRAVIAVPLVAGGEVIGVLSVSSARTGAFGPEDRDLAQLIANCAVPAIEKSRLGRLAITDWLTRAYNHRYLAPRLEEEVERARRHAEPLSLALLDLDHFKRVNDAHGHDAGDAVLRAFVDRVRAEVRRHDVVVRRGGEEFVLIMPETGAADAFLVAERVRARVSGGPIALGEGRETTITVSIGIATWRGERAQALEQRADAALYRAKGEGRDRVIVDLG
>NZ_CP011125.1|WP_053233235.1|3671666_3672884_-|threonine--tRNA-ligase
MLDDSDHRAIARRLGLLHFQEEAPGMVFWHPRGLAMYRALEDAQRAQVRREGYEEVRSPQVMRRPMWEASGHWKHFAEGMMRIQDDELEAALKPVSCPGHVQIVKRMAPSYRDLPVRLAELGVVHRDEASGALHGLMRLRQFSQDDGHVFCEEAQAEDEVVRFLEGLRPFYAQFGFHELDVALSLRPEDRAGDDVVWDRAEALLARALDRRGEKHRVQEGAGAFYGPKIEIALRDRAGRLWQCGTIQMDLVMPVRFDLRYVDARGEKQPVVMLHRALYGSLERFLGILLEQHGASLPAWLAPEQVVVVPVSGAQHENARALARELERDGARVSIDAREESLARRIAEAHERGVPYVAIVGAREAERGEVALRSRLLPESKGQRVMAIDAARAYLREALVRPERAS
>NZ_CP011125.1|WP_053233236.1|3673123_3673711_-|hypothetical-protein
MWAHFIYRVHAASVGGVGRAIARNAELIARPNSGHSYGHVVEHVCRYEGARRVVMLDRDPHRAAYWHSLASEEDVLRLVHERRGNTLFGRGTATDTPYAALMTELRARYRAVGTREEERALLREAEARAEPLVVSEETRTTWRVLLARWKWTKRHTSATSFPFLRAGIDVYKADGFELGTPGAGTAFYAFALFHY
>NZ_CP011125.1|WP_053233237.1|3673798_3676216_-|endopeptidase-La
MADDDEKTGELTDQDLSFGDELPVLPIRNAVLFPGAVAPFDVGREKSVALVEDIDNLAQPVIAIFAQRDPSTDDPSQADLYPVGVAARVLKALKHSSGNYSLILQGLVRIRMEGVQQLDPYMRARISRLDQPKAEDVETEALAMSLRDIAKQVIQLMPELPREATSLIDSINEPGQLADLVAANLDAPVDEKAQLLETIDVKERIRKVLRLLTRQLEILKMRERINSQIKEEMGKNQREYVLRQQLKAIKEELGEEDGDQGDLDVLDERITKANLPQEAEQVARKQLKRLRSMQVGSAEYTVVRTYIDWILDIPWSKETTDNMDIGEVRRVLEEDHSGLDKVKKRIVEYLAVRKLKKDKKGPILCLIGPPGVGKTSLGRSIARSLGRKFVRISLGGVHDEAAIRGHRRTYVGALPGQVIQGMKKAGTINPVFMLDEIDKIGHDFRGDPAAALLEVLDPEQNDTFADHYLEIPYDLSKVMFVATANVGDTIPPPLRDRMEIIEIPGYTRKEKLDIARDHLLPKQLEEHGLKASQVDITIKALENVIDHHTREAGVRNLERQIATVIRGIAVKVAEGNQGPFRVETEEDLRPYLGPPRFISDVAERTAETGVATGLAWTSVGGEILFIEATRMHGSGKLQLTGQLGDVMKESAQAAMSYVRTRAKALGIAEDFLEKHDIHIHIPAGAMPKDGPSAGVTMMTSLVSLLTGINVRHDVAMTGEITLRGRVLPVGGIKEKVLAAHRAGIKRVILPERNVADLEEVPGEIKNELEFVSVSKMDDVLEAALEEPSRLKLKVETPATTGAAPA
>NZ_CP011125.1|WP_053233238.1|3676435_3677197_-|methyltransferase-domain-containing-protein
MRADEHERMYRVETRHFWFTGTRRVIVSALERALGSRLAGARVLDLGCGTGFTLTRLPDGVRSVGLDYSPAALAFARERATSSALVRGSAYALPFADASFDAVLALDVLEHLDDDLAAARELRRVLAPGGAAIVTVPAFQALWSAHDEALDHRRRYRLSRIEAVLREAGLTIEHGSYYNFFLFPAVAAARLAERARVALGLTRTSSPEGTGTDLRVPPAPINDALAALLGAERAIAPRMRLPFGVSCLVVARA
>NZ_CP011125.1|WP_053233239.1|3677264_3678287_+|hypothetical-protein
MASSSIAEYFTLRDASATAARIPETKRKEIADALALGRQKAEAAEALWSNGHAAEGLRLVVEALIATLDAAPRYESATTAPAKEPAPKIEGESELGESDAPKSEPAPATWRTALAARGVSADRVRAIGDAEDKARTTALPRLDSDVSAEHADLYQQIARARLDVERALAYAAMSARELGWTRVARIATAAVLGVALITALYFVVRTPHEVTADASATFANSPTFGAGNAIDGDANSEWLLPDRSSGWVEARLSPPRHVARVTLRNAKNAPHFDRATREYRIELYSGGRVVEQIDGEFATYERDPQPVSHDFDADGIDRVRFVSRSHHNLGGGLAEMTVEE
>NZ_CP011125.1|WP_157069067.1|3678292_3678904_+|hypothetical-protein
MRSMLAIIALLAGCTCGPQGGGTPVPHEAPAQRAETPSAEAPAQPEFEDAAGGLAWRAEEPLISRRPSSPMRAAEYAVRDHEGAELTVFHFGRDQGGGVDENVARWVDQFEQPDGRPSREVAVIERAEVNGIRVTRVQVAGAFAGMRGMGGGGGAAQPGYRLLGAIAEGPDGMVFFKLTGPEAAVQDASSAFESLIASLHPAG
>NZ_CP011125.1|WP_075097527.1|3678913_3681307_-|polyphosphate-kinase-1
MDKAPLAGRADGTLVEASATSASAIRIEPATRPSSIPPPPAEGGSAPDLVRGTTDLFINRELSWLEFNQRVLDEARDRSVPLLERLKFVSICASNLDEFFMVRVAGLVGQRRDRVHVVASDGMSPAEQLAAIAKRVGRMRGEMSELLLEDLLPELAGRGVRLLAARDVGIDGRAQLRQYFRDQVLPVLTPLAIDPGHPFPHLRNKSLNLIAMLSGSHRQAVAPAFAMVQVPGVLPRLVRVTSADEGTKAAYVLLDDLIALHIGDLFPGFRCLGAWPFRVVRNFDLSIDEEEAEDLLESVKQEVRRRDRGNAVSVLIDGRAHQAAQDMLREALRVDTEYVFTVDGPLNLPDLVQLGESLDSDHELRDPAFTPQLVPPFRHEEEPIFAVIAKRDVLLHHPYESFDPVVHFIEEAATDPDVLAIKQTLYRTSGDSPIVKALMRAADHGKQVTALVEIKARFDEENNIQWARKLEEAGVHVVYGLLGLKTHAKAALVVRRENGELKRYVHLGTGNYNPSTARLYTDLSFFTARPDIGEDASSLFNLLTSCTAPATWRKLIVAPLGLHERVLGLIEREAAAARAGRPARIVAKMNSLVDPDVILALYRASQAGVRIDLMVRGICCLRPGLPGVSDNIRVSSIVDRFLEHARIFVFEADGAQEVYCASADWMQRNFHRRVEVMFPVEDPVLKARIVEEVLGTEMRDNVKRRSLRADGHWDRAQPDAGEDAVRAQRVFLHRARDAAARADAKVRHERPFIVRPVRNRPTKTPDGLDVEPAPPRDSVPEGLLSVPPPAPGSRENG
>NZ_CP011125.1|WP_053233240.1|3681380_3683072_-|family-1-glycosylhydrolase
MVGFDVRTLACAIALGLALAACGDDDGPVDLDAGLDAGAADAGRDASWPDGGPPDPVTFPEIGPLAGDEGEGSFRFGVATAATQIEDMNPSTDWYAFTAPTSEGGLGRGTFVGDAVRGYTNAVADVALLEQIHVDSYRFSVEWARVEPQRDQVDEDALAHYSALLDALVTAGIRPMITVHHFSNPTWVDDPRRDPDDCTGAFPNDEWLCGFGHPTGGAQIVEEIGEHACRLAEEYGDRVDEWGSINEPVNYLFASYGAGGQFPPARSYVLSDFPYFMNIVRDAIRAHVAIYDAIKRCDTVDADGDGANASIGIPLSVAYWTPARGGQPSDLEADVAATERMTYVYHYLLVDSLRNGTFDPDLDGTGDEAQPTWAGKLDWLGVQYYFRAGVTAQPAALRPLGLTPCFAALDFGACLDPIDDTHWIPAMRYEYWEPGLGEILLAMGERWPDLPLVVTEAGISTEVGRRRAENVVRTLEQIARARAAGVDVRGYYHWSLMDNFEWAEGYEPRFGLFRVDRTGDYPRTITEGGTVYGEIAESRELTMQQRLEYGGLGPMTPEPAHAP
>NZ_CP011125.1|WP_053233241.1|3683119_3683428_-|hypothetical-protein
MSKRLEMLEMVASKKPDDPFVWYARAMELRSLDRKDEALAAFGDVATKFPTYVPTYLMGAQVAAELGRTDEARAFAQRGIEQARAGGDGHALSELDSFLATL

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Crispr_ID: NZ_CP011125_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_17

3669522-3669671

Orphan

Consensus_repeat	Method
GACGCGGGCTCGTTCGACGCGGGCCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP011125_17

>merge|NZ_CP011125|17|3669522-3669671|CRISPRCasFinder
GCCGATGCCGCGCTCGACGCGGGGCTCCCGATCGACGTCGACGCGACGTTCCCTCCGTTCGACGCCGGCGTTCCCGAGGACGCGGGCTCGTTCGACGCGGGCCCGTCCGATGCGGGCCCGACCGATGCGGGTGTGCGCGACGCCGGTCCG

>NZ_CP011125|17|13|3669522-3669671|CRISPRCasFinder
GCCGATGCCGCGCTCGACGCGGGGCT	CCCGATCGACGTCGACGCGACGTTCCCTCCGTTCGACGCCGGCGTTCCCGAG
GACGCGGGCTCGTTCGACGCGGGCCC	GTCCGATGCGGGCCCGACC
GATGCGGGTGTGCGCGACGCCGGTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_169791458.1\|3659033_3659891_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238017
NZ_CP011125.1\|WP_083457408.1\|3662377_3664456_-\|beta-galactosidase	unknown	unknown	gnl\|CDD\|366567
NZ_CP011125.1\|WP_075097527.1\|3678913_3681307_-\|polyphosphate-kinase-1	unknown	unknown	gnl\|CDD\|235469
NZ_CP011125.1\|WP_053233230.1\|3667310_3668252_+\|prolyl-aminopeptidase	unknown	unknown	gnl\|CDD\|130316
NZ_CP011125.1\|WP_053233228.1\|3664918_3665611_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP011125.1\|WP_053233224.1\|3659887_3661291_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053233235.1\|3671666_3672884_-\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234752
NZ_CP011125.1\|WP_053233231.1\|3668276_3669284_-\|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|234629
NZ_CP011125.1\|WP_053233237.1\|3673798_3676216_-\|endopeptidase-La	unknown	unknown	gnl\|CDD\|223542
NZ_CP011125.1\|WP_053233240.1\|3681380_3683072_-\|family-1-glycosylhydrolase	unknown	unknown	gnl\|CDD\|274539
NZ_CP011125.1\|WP_157069067.1\|3678292_3678904_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233238.1\|3676435_3677197_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382
NZ_CP011125.1\|WP_053233239.1\|3677264_3678287_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366285
NZ_CP011125.1\|WP_169791457.1\|3658215_3658950_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233236.1\|3673123_3673711_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233229.1\|3665691_3667311_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP011125.1\|WP_053233234.1\|3670517_3671510_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP011125.1\|WP_053233227.1\|3664510_3664900_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|129116
NZ_CP011125.1\|WP_075097526.1\|3669802_3670510_+\|LamG-domain-containing-protein	unknown	unknown	gnl\|CDD\|379155
NZ_CP011125.1\|WP_053233225.1\|3661298_3662381_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_169791458.1\|3659033_3659891_+\|FHA-domain-containing-protein	gnl\|CDD\|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	1.65045e-17
NZ_CP011125.1\|WP_083457408.1\|3662377_3664456_-\|beta-galactosidase	gnl\|CDD\|366567	pfam01301, Glyco_hydro_35, Glycosyl hydrolases family 35.	1.08313e-33
NZ_CP011125.1\|WP_075097527.1\|3678913_3681307_-\|polyphosphate-kinase-1	gnl\|CDD\|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NZ_CP011125.1\|WP_053233230.1\|3667310_3668252_+\|prolyl-aminopeptidase	gnl\|CDD\|130316	TIGR01249, Putative_proline_iminopeptidase, proline iminopeptidase, Neisseria-type subfamily. This model represents one of two related families of proline iminopeptidase in the alpha/beta fold hydrolase family. The fine specificities of the various members, including both the range of short peptides from which proline can be removed and whether other amino acids such as alanine can be also removed, may vary among members.	5.74447e-95
NZ_CP011125.1\|WP_053233228.1\|3664918_3665611_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.58788e-84
NZ_CP011125.1\|WP_053233224.1\|3659887_3661291_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.64896e-101
NZ_CP011125.1\|WP_053233235.1\|3671666_3672884_-\|threonine--tRNA-ligase	gnl\|CDD\|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
NZ_CP011125.1\|WP_053233231.1\|3668276_3669284_-\|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	gnl\|CDD\|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	7.77458e-180
NZ_CP011125.1\|WP_053233237.1\|3673798_3676216_-\|endopeptidase-La	gnl\|CDD\|223542	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP011125.1\|WP_053233240.1\|3681380_3683072_-\|family-1-glycosylhydrolase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	1.67435e-58
NZ_CP011125.1\|WP_053233238.1\|3676435_3677197_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	9.32388e-26
NZ_CP011125.1\|WP_053233229.1\|3665691_3667311_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.37749e-55
NZ_CP011125.1\|WP_053233234.1\|3670517_3671510_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.78241e-58
NZ_CP011125.1\|WP_053233227.1\|3664510_3664900_-\|RidA-family-protein	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	1.02478e-55
NZ_CP011125.1\|WP_075097526.1\|3669802_3670510_+\|LamG-domain-containing-protein	gnl\|CDD\|379155	pfam13385, Laminin_G_3, Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	8.83871e-11
NZ_CP011125.1\|WP_053233239.1\|3677264_3678287_+\|hypothetical-protein	gnl\|CDD\|366285	pfam00754, F5_F8_type_C, F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.	0.00378335

>NZ_CP011125.1|WP_053233231.1|3668276_3669284_-|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase
MTHTIAVLGAGAWGTALAKALSDKGHQVHLWSWQKPHADAIQRDRTNQDFLPGFELAPTLRATSDLPDALGGADMVLTAVPTHVLREVLGKAAPHLPESAPILSVSKGIEISTLKVVSGIFEDCVPKETLDRVAYLGGPSFAKEVAAGMPTAVVVACTSHDVACRWQEALATDRLRVYTTDDVIGIELGGALKNVIAIAAGVSDGLGFGHNSRAALITRGLAEMTRLATKMGAHPLTLAGLGGMGDLVLTCTGDLSRNRTVGLELGKGRKLDDILAGMTQVAEGVRTTKAAYALAQREGCEMPITDAMYRILYEGQSPLEATVELMTRRKRAERD
>NZ_CP011125.1|WP_053233230.1|3667310_3668252_+|prolyl-aminopeptidase
MFPPIEPFATGRLRTRDGHEIHWETSGNPRGKPALYLHGGPGAGLMTGHRRRFDPERWLVVALDQRGCGRSTPLVIDALDTLATNTTDALIADIEALREHLGIDAWLVYGVSWGTTLALAYAQAHPARVTELVLMCVVQTSASEVAWITEDLRRVFPREWSRFEAASKRRSGQRVIDAYHALITSADATEREEAARAWCAWEDTHVSLDPRHRPEPRFETDAVFRQTFATLTIHYWKHAAFLEDGALLSRIDRIAHIPAALIHGRLDISSPLEWPWQLHLAWPKSTLTIVDDEGHGGDTMIDEVVRAIARFAP
>NZ_CP011125.1|WP_053233229.1|3665691_3667311_+|HAMP-domain-containing-histidine-kinase
MEWRSRLVYLALIPAIAIAAGILGYFSIQSARQFARESEQSVLASTLVLVDEKVDRVEQMIITSDEAVFHLVDLERPEAVSETWQPLAERISPSVRALLVLDDGGEVIGYACRCSTQERRDFLKVFTERILPNLELERERIGVLRHHHRTYADTSYLISYRAVRHAGRRHYMVAHHDTGFIEREVFPTLFVHEEERVSYNVVDDDNRLVYGQSRIARAGDYLVGRRFPTTLYGWRLQIAPKRAPELIVRGAEQVYTESALIGLSFAIVLLGVGFLIYAAVKESRLNALRSEFIANVSHELKTPLSVVRMFSEMLMTGRVRDEKKREQYLQIIARESERLTALIDNVLDFSAIERGKQTYQMREGDLADVVARAIDTFRYRLERENLEVKLEVVGEVPAVRFDEQAILLAVMNLLDNAMKYGAGSTIEVTIERGRRHAYVRVRDHGPGIPDEHHKRVFERFYRVRNGSSSARGSGIGLSLVKRIVEAHRGRAWVENAAGGGARVSFSLPFSDLAGGGTAVALSSWRNDAGPPPDDEIAER
>NZ_CP011125.1|WP_053233228.1|3664918_3665611_-|response-regulator-transcription-factor
MATPERRILLVEDDPAIALGLVDSLEFEGFAVTHARTGQEGIQLARSEHPDCIILDLMLPDTNGYRVCEQIRAHDTLVPILMLTARSQEADKIRGLDAGADDYVTKPFSVGELVARIRAIFRRTTRAQITEAPIRIGTASIDPAAQTMKRGRETTSLSFYEVQLLKYLFERAGQVVSREELLDKVWGVEGTPTNRTIDNFIVKLRKKIEPNPEKPAHILTVYGLGYKLVV
>NZ_CP011125.1|WP_053233227.1|3664510_3664900_-|RidA-family-protein
MAKRDVLSSEHAPKAIGPYSQGIRCGQMVFFSGQIPLDANGEFVGQGDVRAQIEQVMKNVDALLKSAGLGFDDVVKATIFLVDLADFATVNEVYAKRFEGIAPPARSTVQVAALPRGARVEVEIIAIAG
>NZ_CP011125.1|WP_083457408.1|3662377_3664456_-|beta-galactosidase
MKPKRPAARPATRARAVRRVGGVRLEDGALRIADRSVPLLCGAVHYWRLERESWRAALSETRALGIPIVETYVPWQVHELAPGDYDFGQRDPRKDVGAFLDLAADLGLYAFVRPGPHINSEMTWFGLPERIVYDKSIQARSPKQSPVVLGFPPRMFPVPSYASEQYHLESQRWLEAAAAQLAPRLWPQGPIVLLQVDNEATYWFRDSAYDQDYHPDAIAGWRAWLAQRYGTPYEAGRAHRREYAAWDDVVAPERFDAETPEQLALHLDWGAWREELITRALVRFKGAMATAGLKGVPTVHNLPLGEQAAPVSTPRIEEIVDLVGLDYYHARREHRTIKRRTLFLAGSSRLPFAPEMGVGAPPWFTPLTHEDSLFCAMSACAYGLRGMSLYMTVDRDRWYGAPIDATGNPRLEAGAWKSFLHALTSIGFHRLQRRVEVGLALPREYSRLSRATHLMGVLSPITLEAIGGSPVEACSEEPLGFAGPIQVLWWTMIARFAEALTAAGVPYVYVDGDAPEERYDGLRVVIAPTYEFASVARWSRLCDFASEGGTVVFGPAMPTLDDTMRARPFEVPRHGRKVLIDRPEDADEVVRTLVHDLGLETPFRASPAPVETTVHEDEGGPRVLFVINPAPERIEAIVELPYAIAFEDSASGDRFAGDRSITVPMAPHACRMLVVRRSAQEEGAQATAGRVS
>NZ_CP011125.1|WP_053233225.1|3661298_3662381_-|hypothetical-protein
MIAADLRVEGFDARSWTNLISLFAPGVVTRIQREPAPSDAPELDTKEAEDAGLSEQRSTGSLVIVISETGRVRKAFHSQRGRIRDLAQASPSELPMITERYRARRALLMREGAIEEIAERVAVRLERGDDYVAQWLVVARTIREVIDAGMIHVWPRPLAGVPIPTAGMVRRALDTVLPDDRALVMVIWSGSTPWTGVVLRRRRGEIDLVAGPDLIARWSGPLGGDWRRDHRFVSEGIARAVAPVHLGIYAEIGSIRRLLRSAEPGAWARAVAVRDVIVSPTPPYVAVAIGADAARAVAQRTTTWLGGIDALASLAPAVTYVRGRISEIASVTQTLGFDPLKLLAGSLARSEDGDEKNDER
>NZ_CP011125.1|WP_053233224.1|3659887_3661291_+|serine/threonine-protein-kinase
MTRSTIHAIRPSEVERAPVGVPGVILGGKYRLDEAIARGGMARVWRATHVTLNRPVAVKFVDAWGATPEERNERFLREAKVAASVRHRHVVDIIDFGTSRNGEPYMVMELLEGETLDQRLGRGPVPVDEVIEIAAQLLSGLDAVHRAGIVHRDLKPGNVFLTHDEVDGVFARLLDFGISQGADEIATESDRVVVGTPEYMSPEQAFGEPLDARSDLYAVGVVLYEMLSGVLPFEDPDPQKVVELVAHGTPAPLLSMRPDIPEICAVIARAMSPMPEARFDSAREMRRALLDAVGRGPDVTGRSSAVPRDSRVSGLQARAVATVAASGVTRSGETLAETLAPPEGPRARTRWTVMAVVLLVVVGAGAMWLAMQGGEERAAGDDAPPSAAMQAAEPSPSTAVPSTGPEEAAAAAEGDDGEASEAESTDEALPERSTRRPRRRARRATRDGEEPDPSTPSEPTIRRELDF
>NZ_CP011125.1|WP_169791458.1|3659033_3659891_+|FHA-domain-containing-protein
MPNGVSPRFRSSLVAIRLQDRVMARFRLRLQDREIALPAGGELVVGRDATVADVALDDRLVSRRHAAFRCHGDDELEIVDLESLNGVRVNDVPVKGVRALGHRDRVQIGAHVFLVVDQRREHRSNAPTTRGSMRTASATRPTPRAQRAIVTPLDTIAQALADDDLSAAVVAMDAVIARYGDPSEALMPGELGRVVELLLALSERTGDMRFFDRVFQIHTGRRLVIDGASIDAIQNALPHLERASSQGLDTYLAAMGARGATLSPQEQVRLRRIAALTRRVGKGKA
>NZ_CP011125.1|WP_169791457.1|3658215_3658950_-|hypothetical-protein
MRDTAAARALFQEGVACADRSDWTCAADRFARAHELRASAVIAYNLGHALVESGRLVEGTEILRRLVRDESVAANVRADAARVIRDAEPRIGRLAVHLRGPHEDVEVALGTHELASSLLGTAAPVDPGEHVLEARRDGEIVASARVHIDPGATEEIELEIPARPARATASAIAPEAAAQTAFDATGARDVAPSEGGDDGTWIALGVAGGVLVVAAAVVVGVVLAAPAQEPAPFDGTLGWVEIGR
>NZ_CP011125.1|WP_075097526.1|3669802_3670510_+|LamG-domain-containing-protein
MRDAGARDAGPIDGGRRSPALRFTPDRYLLVPDRPGLRVGGDTTTELWIRARGTGIIARKGQDDGQRHLVIELAPGPDGRVELIAGWTTVRSERRELRAPFDAFGDWTHVALTIQRTAGVLRTLLYVNFTVVAMADFPDDIGDAFNIEPLLIGRFDGDLDEIRIWNTVRSAAALQAAAFTRLSTGTATLAAYWPLEEAPAGQIALDRSLRGNDAILGQITTTDPRDPTWILDGAL
>NZ_CP011125.1|WP_053233234.1|3670517_3671510_-|diguanylate-cyclase
MLGGGQDALHVLLDLTRRLAEPIELEAQLQATTDAALAILPGDHASLRLFDEGKSELLSSARSGTGVTQPPATFRRGQGVVGAVAESGRSTLVPDALEDPRFVAYPTQGFEVRAVIAVPLVAGGEVIGVLSVSSARTGAFGPEDRDLAQLIANCAVPAIEKSRLGRLAITDWLTRAYNHRYLAPRLEEEVERARRHAEPLSLALLDLDHFKRVNDAHGHDAGDAVLRAFVDRVRAEVRRHDVVVRRGGEEFVLIMPETGAADAFLVAERVRARVSGGPIALGEGRETTITVSIGIATWRGERAQALEQRADAALYRAKGEGRDRVIVDLG
>NZ_CP011125.1|WP_053233235.1|3671666_3672884_-|threonine--tRNA-ligase
MLDDSDHRAIARRLGLLHFQEEAPGMVFWHPRGLAMYRALEDAQRAQVRREGYEEVRSPQVMRRPMWEASGHWKHFAEGMMRIQDDELEAALKPVSCPGHVQIVKRMAPSYRDLPVRLAELGVVHRDEASGALHGLMRLRQFSQDDGHVFCEEAQAEDEVVRFLEGLRPFYAQFGFHELDVALSLRPEDRAGDDVVWDRAEALLARALDRRGEKHRVQEGAGAFYGPKIEIALRDRAGRLWQCGTIQMDLVMPVRFDLRYVDARGEKQPVVMLHRALYGSLERFLGILLEQHGASLPAWLAPEQVVVVPVSGAQHENARALARELERDGARVSIDAREESLARRIAEAHERGVPYVAIVGAREAERGEVALRSRLLPESKGQRVMAIDAARAYLREALVRPERAS
>NZ_CP011125.1|WP_053233236.1|3673123_3673711_-|hypothetical-protein
MWAHFIYRVHAASVGGVGRAIARNAELIARPNSGHSYGHVVEHVCRYEGARRVVMLDRDPHRAAYWHSLASEEDVLRLVHERRGNTLFGRGTATDTPYAALMTELRARYRAVGTREEERALLREAEARAEPLVVSEETRTTWRVLLARWKWTKRHTSATSFPFLRAGIDVYKADGFELGTPGAGTAFYAFALFHY
>NZ_CP011125.1|WP_053233237.1|3673798_3676216_-|endopeptidase-La
MADDDEKTGELTDQDLSFGDELPVLPIRNAVLFPGAVAPFDVGREKSVALVEDIDNLAQPVIAIFAQRDPSTDDPSQADLYPVGVAARVLKALKHSSGNYSLILQGLVRIRMEGVQQLDPYMRARISRLDQPKAEDVETEALAMSLRDIAKQVIQLMPELPREATSLIDSINEPGQLADLVAANLDAPVDEKAQLLETIDVKERIRKVLRLLTRQLEILKMRERINSQIKEEMGKNQREYVLRQQLKAIKEELGEEDGDQGDLDVLDERITKANLPQEAEQVARKQLKRLRSMQVGSAEYTVVRTYIDWILDIPWSKETTDNMDIGEVRRVLEEDHSGLDKVKKRIVEYLAVRKLKKDKKGPILCLIGPPGVGKTSLGRSIARSLGRKFVRISLGGVHDEAAIRGHRRTYVGALPGQVIQGMKKAGTINPVFMLDEIDKIGHDFRGDPAAALLEVLDPEQNDTFADHYLEIPYDLSKVMFVATANVGDTIPPPLRDRMEIIEIPGYTRKEKLDIARDHLLPKQLEEHGLKASQVDITIKALENVIDHHTREAGVRNLERQIATVIRGIAVKVAEGNQGPFRVETEEDLRPYLGPPRFISDVAERTAETGVATGLAWTSVGGEILFIEATRMHGSGKLQLTGQLGDVMKESAQAAMSYVRTRAKALGIAEDFLEKHDIHIHIPAGAMPKDGPSAGVTMMTSLVSLLTGINVRHDVAMTGEITLRGRVLPVGGIKEKVLAAHRAGIKRVILPERNVADLEEVPGEIKNELEFVSVSKMDDVLEAALEEPSRLKLKVETPATTGAAPA
>NZ_CP011125.1|WP_053233238.1|3676435_3677197_-|methyltransferase-domain-containing-protein
MRADEHERMYRVETRHFWFTGTRRVIVSALERALGSRLAGARVLDLGCGTGFTLTRLPDGVRSVGLDYSPAALAFARERATSSALVRGSAYALPFADASFDAVLALDVLEHLDDDLAAARELRRVLAPGGAAIVTVPAFQALWSAHDEALDHRRRYRLSRIEAVLREAGLTIEHGSYYNFFLFPAVAAARLAERARVALGLTRTSSPEGTGTDLRVPPAPINDALAALLGAERAIAPRMRLPFGVSCLVVARA
>NZ_CP011125.1|WP_053233239.1|3677264_3678287_+|hypothetical-protein
MASSSIAEYFTLRDASATAARIPETKRKEIADALALGRQKAEAAEALWSNGHAAEGLRLVVEALIATLDAAPRYESATTAPAKEPAPKIEGESELGESDAPKSEPAPATWRTALAARGVSADRVRAIGDAEDKARTTALPRLDSDVSAEHADLYQQIARARLDVERALAYAAMSARELGWTRVARIATAAVLGVALITALYFVVRTPHEVTADASATFANSPTFGAGNAIDGDANSEWLLPDRSSGWVEARLSPPRHVARVTLRNAKNAPHFDRATREYRIELYSGGRVVEQIDGEFATYERDPQPVSHDFDADGIDRVRFVSRSHHNLGGGLAEMTVEE
>NZ_CP011125.1|WP_157069067.1|3678292_3678904_+|hypothetical-protein
MRSMLAIIALLAGCTCGPQGGGTPVPHEAPAQRAETPSAEAPAQPEFEDAAGGLAWRAEEPLISRRPSSPMRAAEYAVRDHEGAELTVFHFGRDQGGGVDENVARWVDQFEQPDGRPSREVAVIERAEVNGIRVTRVQVAGAFAGMRGMGGGGGAAQPGYRLLGAIAEGPDGMVFFKLTGPEAAVQDASSAFESLIASLHPAG
>NZ_CP011125.1|WP_075097527.1|3678913_3681307_-|polyphosphate-kinase-1
MDKAPLAGRADGTLVEASATSASAIRIEPATRPSSIPPPPAEGGSAPDLVRGTTDLFINRELSWLEFNQRVLDEARDRSVPLLERLKFVSICASNLDEFFMVRVAGLVGQRRDRVHVVASDGMSPAEQLAAIAKRVGRMRGEMSELLLEDLLPELAGRGVRLLAARDVGIDGRAQLRQYFRDQVLPVLTPLAIDPGHPFPHLRNKSLNLIAMLSGSHRQAVAPAFAMVQVPGVLPRLVRVTSADEGTKAAYVLLDDLIALHIGDLFPGFRCLGAWPFRVVRNFDLSIDEEEAEDLLESVKQEVRRRDRGNAVSVLIDGRAHQAAQDMLREALRVDTEYVFTVDGPLNLPDLVQLGESLDSDHELRDPAFTPQLVPPFRHEEEPIFAVIAKRDVLLHHPYESFDPVVHFIEEAATDPDVLAIKQTLYRTSGDSPIVKALMRAADHGKQVTALVEIKARFDEENNIQWARKLEEAGVHVVYGLLGLKTHAKAALVVRRENGELKRYVHLGTGNYNPSTARLYTDLSFFTARPDIGEDASSLFNLLTSCTAPATWRKLIVAPLGLHERVLGLIEREAAAARAGRPARIVAKMNSLVDPDVILALYRASQAGVRIDLMVRGICCLRPGLPGVSDNIRVSSIVDRFLEHARIFVFEADGAQEVYCASADWMQRNFHRRVEVMFPVEDPVLKARIVEEVLGTEMRDNVKRRSLRADGHWDRAQPDAGEDAVRAQRVFLHRARDAAARADAKVRHERPFIVRPVRNRPTKTPDGLDVEPAPPRDSVPEGLLSVPPPAPGSRENG
>NZ_CP011125.1|WP_053233240.1|3681380_3683072_-|family-1-glycosylhydrolase
MVGFDVRTLACAIALGLALAACGDDDGPVDLDAGLDAGAADAGRDASWPDGGPPDPVTFPEIGPLAGDEGEGSFRFGVATAATQIEDMNPSTDWYAFTAPTSEGGLGRGTFVGDAVRGYTNAVADVALLEQIHVDSYRFSVEWARVEPQRDQVDEDALAHYSALLDALVTAGIRPMITVHHFSNPTWVDDPRRDPDDCTGAFPNDEWLCGFGHPTGGAQIVEEIGEHACRLAEEYGDRVDEWGSINEPVNYLFASYGAGGQFPPARSYVLSDFPYFMNIVRDAIRAHVAIYDAIKRCDTVDADGDGANASIGIPLSVAYWTPARGGQPSDLEADVAATERMTYVYHYLLVDSLRNGTFDPDLDGTGDEAQPTWAGKLDWLGVQYYFRAGVTAQPAALRPLGLTPCFAALDFGACLDPIDDTHWIPAMRYEYWEPGLGEILLAMGERWPDLPLVVTEAGISTEVGRRRAENVVRTLEQIARARAAGVDVRGYYHWSLMDNFEWAEGYEPRFGLFRVDRTGDYPRTITEGGTVYGEIAESRELTMQQRLEYGGLGPMTPEPAHAP

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Crispr_ID: NZ_CP011125_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_19

4199023-4199097

Orphan

Consensus_repeat	Method
GTTCGGTTCCGGGTCGGGATCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_19

>merge|NZ_CP011125|19|4199023-4199097|CRISPRCasFinder
GTTCGGTTCCGGGTCGGGATCGCCGCGCAGGATGACCCGGTGGAAGCCGAGGTTCGGCTCCGGGTCGGGATCGCC

>NZ_CP011125|19|15|4199023-4199097|CRISPRCasFinder
GTTCGGTTCCGGGTCGGGATCGCC	GCGCAGGATGACCCGGTGGAAGCCGAG
GTTCGGCTCCGGGTCGGGATCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_157069132.1\|4205367_4205907_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069134.1\|4211570_4212866_-\|TonB-family-protein	unknown	unknown	gnl\|CDD\|367555
NZ_CP011125.1\|WP_053233657.1\|4190385_4191384_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233667.1\|4203818_4205273_-\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP011125.1\|WP_053233664.1\|4198066_4198855_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP011125.1\|WP_169791474.1\|4199490_4203657_-\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226350
NZ_CP011125.1\|WP_053233672.1\|4209042_4210149_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235904
NZ_CP011125.1\|WP_053233661.1\|4193873_4196084_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|236901
NZ_CP011125.1\|WP_157069133.1\|4208675_4208969_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069131.1\|4187550_4189008_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
NZ_CP011125.1\|WP_053233670.1\|4207394_4208666_-\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240573
NZ_CP011125.1\|WP_053233663.1\|4197650_4198070_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233656.1\|4189532_4190312_+\|Ig-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379073
NZ_CP011125.1\|WP_053238853.1\|4189249_4189504_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069135.1\|4212935_4213739_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233673.1\|4210145_4211555_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_083457454.1\|4205914_4207303_-\|response-regulator	unknown	unknown	gnl\|CDD\|223715
NZ_CP011125.1\|WP_053233658.1\|4191541_4192651_-\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_CP011125.1\|WP_053233654.1\|4186311_4187550_+\|cytochrome-c3-family-protein	unknown	unknown	gnl\|CDD\|379636
NZ_CP011125.1\|WP_053233662.1\|4196130_4197651_-\|GMC-family-oxidoreductase	unknown	unknown	gnl\|CDD\|225186

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_157069134.1\|4211570_4212866_-\|TonB-family-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	3.79624e-10
NZ_CP011125.1\|WP_053233656.1\|4189532_4190312_+\|Ig-like-domain-containing-protein	gnl\|CDD\|379073	pfam13205, Big_5, Bacterial Ig-like domain.	4.09395e-11
NZ_CP011125.1\|WP_053233667.1\|4203818_4205273_-\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	2.18836e-106
NZ_CP011125.1\|WP_053233664.1\|4198066_4198855_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	2.27018e-40
NZ_CP011125.1\|WP_169791474.1\|4199490_4203657_-\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|226350	COG3829, RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms].	9.50705e-109
NZ_CP011125.1\|WP_053233661.1\|4193873_4196084_-\|GAF-domain-containing-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	1.01998e-72
NZ_CP011125.1\|WP_053233672.1\|4209042_4210149_+\|hypothetical-protein	gnl\|CDD\|235904	PRK06995, flhF, flagellar biosynthesis protein FlhF.	0.00427606
NZ_CP011125.1\|WP_053233670.1\|4207394_4208666_-\|metallopeptidase-family-protein	gnl\|CDD\|240573	cd12953, MMP_TTHA0227, Minimal MMP-like domain found in Thermus thermophilus hypothetical protein TTHA0227 and similar proteins. The subfamily includes an uncharacterized protein from Thermus thermophilus (TTHA0227) and its homologs from bacteria. Although its biological role remains unclear, TTHA0227 contains a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets and a HExxH (x could be any amino acid) motif. It may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD motif.	1.97704e-12
NZ_CP011125.1\|WP_157069131.1\|4187550_4189008_-\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	6.21082e-40
NZ_CP011125.1\|WP_083457454.1\|4205914_4207303_-\|response-regulator	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.57272e-35
NZ_CP011125.1\|WP_053233658.1\|4191541_4192651_-\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_CP011125.1\|WP_053233654.1\|4186311_4187550_+\|cytochrome-c3-family-protein	gnl\|CDD\|379636	pfam14522, Cytochrome_C7, Cytochrome c7 and related cytochrome c. This family includes cytochromes c7 and c7-type. In cytochromes c7 all three haems are bis-His co-ordinated. In c7-type the last haem is His-Met co-ordinated.	2.35032e-05
NZ_CP011125.1\|WP_053233662.1\|4196130_4197651_-\|GMC-family-oxidoreductase	gnl\|CDD\|225186	COG2303, BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism].	4.76189e-47

>NZ_CP011125.1|WP_053233664.1|4198066_4198855_-|FadR-family-transcriptional-regulator
MAPADPRKRAAVEAANRIRDEILTGRYPSGSSLPGERELSEQLGVSRLTLRSALAHLEAEGLVRPYHGSGTRVLDFREHGGIDLLGYLARLAFEGRVVPIDVLADLLELRRSVAVDAVGLAAERATAEEIHAMREHLAMQAELMDQPRAFMQADIAFARRVVRATHNLAFELIYNTVARTLESNAGLELAFFANAPQTLRVYARLIDIVEKREAERARRATRALLERLDRTTLSRVGAFLGMTVREGAHDGDTDHEAEEELR
>NZ_CP011125.1|WP_053233663.1|4197650_4198070_-|hypothetical-protein
MNGWAALVLSSFAPADDAGGLVKSGDEIDWGAAWTRFTSTMSAKGRLGAYAGLVICVFAPLLAMGRFATIARLSITERARALDVLLSHRSFAIRELTLLLKIVACMAIFRSSAARERSGYDRPVGSAKLRLPTLATEAA
>NZ_CP011125.1|WP_053233662.1|4196130_4197651_-|GMC-family-oxidoreductase
MAQQRIDDAADFVIVGTGAGGATAARVLADAGLDVVLLEEGPEIPLADRRREALDAMSVAVRDMASQTTDGIHPIPLLQGRVVGGSTAINSGIIWRLPDDVRRDWCERFGLEKLVDETEMERVFARIEDELGVHETEGELLGGNNTLMERGAQALGLPGRRIHRNTKGCQGNNRCLQGCPVGARQSMDVSYVPRAIADGARLHSSCRATRVVFEGRRAVAVRGTVHDPKTRARVGSFEVRARRGVIVAASAIWTPVLLQNSGYRHPLLGERFQAHPGAAFVGRFDEPVNMGFGAAQGYEVPMRDRGYKLESLGMPAEMLAARLPGAGADWSKRLANLGHYVQWGGQVRMEALGRVRARWFPGASGGGVSVKYEPTKRDIAKLHDALVLTGRMMLAAGAKEIHPGVAGFPDTISTEAELDAFARHPLHRSQAHLVASHLFGTACASRDPKLGVVDDELAAHGAERLYVMDASVFPTNLGVNPQHSIMGVVWRASEMLAQRASRAAAA
>NZ_CP011125.1|WP_053233661.1|4193873_4196084_-|GAF-domain-containing-protein
MDLRTQISLVASILCFALSAVVLLRPRKRRVHWLFALFDGTVGAWYLTTFLARFEGGGAFWERLNLVWAVLLPLSAVQFFRAFLQSDSRRSGQLNHTAIFLAIGMIAAIFTPLYRALVLGTAVFVYVFVLLAAALVIVYRAGRRARSRFDRARLLYLALVGTFAAVFTLAEYLPYVGLDIPPVGTVLILVFLYVLSQSILSSRILDLYELGARLGVLTTLAFSLAGILWVLVALDPGHFFLHSVTAALVLMLLTEPVRSKIEQQISQLFFRERHDFERMVLDLRRQLANVLSQDDLVRSVVTAFESSRRLTHGSIYLLDADRQGYDLMGHVGAEPARRVELAPGRPFLDRMRRDEALVLENLERELDERRELGEDGEAETLAEIIGTMESMQASVAVALRGPDESYGLICIRDERLRDAYSPEEVQLLKGLAAQASIAVENSRLYQRMKERDRLAALGEMAAGLAHEIRNPLGAIKASAQFLAEPAPRDESTRMDDGAREFLDIIVEEVDRLNRVVSSFLDYARPSQLGDVTPIDVNATVRRTLQLLGPQFGAGVESSLDLDAEVPPVRIDAERLRQVLINLALNAVQAMEGHGRIEVRTRGVSRGDERWVEIHVADTGPGIPQKILKNLFVPFVTTKDRGTGLGLAISQRIVSAAGGLIEVRSSAGIGTTFVVRLPAHVEERRALPVLDQGRIGAGATGNSAPAEGLVGGGDGLGTSADRGAVAGERASSLASNR
>NZ_CP011125.1|WP_053233658.1|4191541_4192651_-|alanine-dehydrogenase
MIIGVPTEIKTREYRVGINPGGVRQLTRAGHEVRIQKGAGIGAGIADKDFEAAGARIVPTAADAWSAEMVMKVKEPLPEEYGYFRPGLILYTYLHLAPLPELTKELMAKKVRAIAYETVQNADGSLPLLRPMSEVAGRMATQVGASCLEKERGGKGLLLGGVPGTRRGHVVVLGGGVVGAHSAKIAVGMGAQVTVLDVDGTRMSYLEDIFGASIETLYSNPTNIEETVAGADLVIGAVLVAGAKAPKLVDEDLIKKMKPGSVVVDVAVDQGGCIATCRPTTHDHPTFELHGVIHYCVPNMPGAVSMTSTFALTNVTITYAERIAREGVVKAIKSSPALALGVNVWDGACVYQAVAEGVGVEYTPLDRVL
>NZ_CP011125.1|WP_053233657.1|4190385_4191384_+|hypothetical-protein
MAVAIGVLAIGSRAEAQRMDLALSRLSVPSEGGVCPNVDGALVCADDDAWRRLATQFAGALIPPILLPAHTRGMRGIYFGVESSITGIDSGADYWARGTEGDTGTDRNRFVDGVLAWSRFNVRKGLPFGFEIGTNVGFLVNTSYWALGAEVRWSLLEGLRDRHASAYFPSLSVRGSVQTLLGDSEVNVTVPAVDVSIGERIIVADTVEISPYLGGQIAWVFADSELVDLTPEVDAFRECDPDPIPPGVEGHTGSDDPPYCRGSGADFNHNVVFPSLRSTRVRLFVGSQVRYEWFALTAAFAFDLLAPSDLDESLPSDLPRQWRVDVGAGVSY
>NZ_CP011125.1|WP_053233656.1|4189532_4190312_+|Ig-like-domain-containing-protein
MLLAAFVIAVACDVPNEPAPDGSAPRVIATVPAPAADDVDRLARMQVVFDRPLAPSSVSAASVRVVSGARVVPIAVHADPTLPGLRIVPQSELDPDARWELRVEGVRDLDGVVAQRHVVVFRTGRAASAPPDEVPPWSEIGPLLAQRCGECHGGEASVLGLDLGSAEGVRSTAIRVASRQTGERPRAGAVVTGLGGMTRIEVFGSAGRPEESYLVYKLLGDPHVAGERMPPPGDAGDHALSRDEIARVAAWIRGGAPTE
>NZ_CP011125.1|WP_053238853.1|4189249_4189504_+|hypothetical-protein
MKELARFLLQNAQIDFSGEITIEQVRQFLREDDSREARALLAKLIEDKGVDDMLVTLADCLKEYIPEGVSEDVIRQQLSMYSES
>NZ_CP011125.1|WP_157069131.1|4187550_4189008_-|glycosyltransferase
MTAFAAVPGSSPHGAALLAIAAAVRGDVDLVTVKTELLSHVERIGDARMFRVPVGEAGALEQRVTFDRAVARQLEAEPYDVVHVRGPFEGAIAADRKHAFGFQLVYEMATFPDEALGAEVERRWSEAHAKSIEHADLVLVPTEAARRAVLESVPAERVVVLPPGIDVGSFDWRPASHESVPRLLYLGSFTADRDLATVLGALRRVVQTRPVRALVAGETDRHRREQMRAMVDAFQLGGVVEVRGEPPPRTLPKIIAGADLCLAPASEAPRFQSLGDLPQPLLEYLACHRPVIAAGVPGVSDALRDEQDGLLYPPGDEGALADAILEMLRDESLRDRTTESGYRRVRELFSSGARRRRIAEIYERLAPGSQDADPWDESFEDGETGALQVASISSLVTPDTGDRDHAVHEEIGADSEEPTTHNALVITDSQSAIELDTSEVLVVKTQPGEEITRDIPAHLDTDPGLLPIDTIAPEATRRTTDTDPG
>NZ_CP011125.1|WP_053233654.1|4186311_4187550_+|cytochrome-c3-family-protein
MRALRYVVAIGIALAFVLGLTSTRTTGQRSASARPRDLGRSTIIYPPQRIALRMDHSLAAHRELDCARCHEGAPTSESSADRLIPAEHTCLPCHAREIDRATPTIETCGTCHVGFVPPASDAGAPIAPVSDVPAARLRFSHRAHVQAGQTCVDCHAGVPDARLATRAHLPTMRDCFRCHAPSGLGDVPAAPRPLECEGCHVASPSGQLRARWPEGWMNPPRWMAGMRHDHEWLVRHRWVAADQGPLCAQCHTESDCTDCHDGRVRPRRVHPSDFLTVHPVYARRDGELGTSGGRCTSCHTISQFCAECHGRLGIAPIAAPDVRTRDRWHPPAAVWVRGPNMHALEAVRSMQSCASCHAEEDCVQCHGARGIGAGVSPHPPGFAMSCRGALETNARACITCHGDVEELRARCR
>NZ_CP011125.1|WP_169791474.1|4199490_4203657_-|sigma-54-interacting-transcriptional-regulator
MRKSFPLRLLEPPRADVYPLAFGEPGEAFVSKGRGVSMQQGTSGSQSAASSQITTNATHASPHDRPVLLERRNFSHAPPVIGSAPNACAGRESEIAKLMESYRRIAQHRDRERLVLLQGPGGIGKSRILGELRGRIRLEGGVVLEGRCEPGRAFGPFAEIVDRALRFLDEVGVVPSSDLDGLACRAGCHRLWHQHGGPEPETSSAIDPNGAPPEIAAFEKRLRFFDAIHQLLRDVATVRAPVLILHHLERADRGTLELLSFLLDLAGDHGSFAGQNEPTALRMMVVASLRDDVAPAHPEAIETLRGHDAAERVPVGALDAQGVRAFLTSEEAIARVIERTGGNPELIELLLEADPLTPRARIERRLARLTPIARELAGALAVHARPASLETLAAIAGVPIEAAARSELPSFDLLTRSIVDGHVLFAFERENDRETCYQLFSPRERRDLHARCIDVCSARLDLQEAVRHAIATGDFARASDLAVAAAASLAARHAHAEAAALLESLLQANSGAGKGATELPLVIREELADLYRIAGNYRGALVHARAVRDALPEDPAAARRVGYLLTVAGEFDAAAEPLEAARRLATARVDAGLATGAEVAEVEAQLAELGYQQGNYDAAREWSEAALERAREAGALRIEIHARNTLGKLALAQKNPAVAAELFEQNRVLAARSGLGHQEAQAHTNLGVAMLLRRELGAAEQACKRAIEVATRASDTRDRAIATENLAVLAHLARDYRRALSHYHVAVGLLKRLGNRAMLGRVANNLGELYLSLGDRARARALSDLAAHVSGTSGPPLRTAQRLRLRGRIEAADGNVGLARQSFESALLAFRSLGDARAAADAQLEVAKLALADGDVPKAREILASLPVEDAPQRAAEVAIVAADLERAAGGETVLSARRAVELAEKAGDDELLLPALVRFARALGDAGDLSHAARVLERAQDVDKKLGANVPEEALAAWQERPARIELMQVQAKLASAWAATYNAGGRHDSVPPPRALAPRGRPVIAETGASDPRFEKWRKRYPNIAGSSTAVASVMSVLDKVSNSDAIVLIRGESGTGKELIAEAIHNNSARATKPIVKVNCAALVETLLLSELFGHEKGAFTGAQSRKKGRFELADGGTIFLDEIGDISPKTQVALLRVLQEREFERVGGTQPIRVDVRIVAATHRDLERMVREGTFREDLYYRLRGVTLEMPPLRRRLDDLPELCGRLLQRIAEERDETAKRMSSAALDLLGGHRWPGNVRELENVLRSATLFADGEELVPEDFAAFADTFQAPDPEVATLRAATTTSAGGTSPGTMAVLGSDSVRDDASSADGEDAPIEMLVYERVRGGATSLFEMKKMLERECIVRALEETNGNITRAAALLGMKRPRLSQLVKEYELGDLGK
>NZ_CP011125.1|WP_053233667.1|4203818_4205273_-|sigma-54-interacting-transcriptional-regulator
MAKNVPHQSVPTGSVETFPTFGDDATDPTPGLVLVYSRLHRQLPSAVAFVDPLTTIGREADNDLSIPEPAVSRYHAVVERREDGCWLIDKGSTNGTIVNGARTHGARLASQDLVRVGDAVFRFADRGVLSYSAYRLDGSVIAAMRPVRHAIRSQLVGGCQIDLLLERVEKVAKTGLACVIHGESGTGKELLARTIHDASERRGPFQAINCAALPANLIESELFGYRKGAFTGATQDKHGLVRAAHLGTLFLDEIGDMPLEAQAKLLRVLQEREVLPIGATQPERVDVRVVCATHRTLEAEVAAGRFRGDLLARLREFSVRIPPLRERREDLHPLVLHFLKRAGRPEATVTLPFMLGLAQYAWPYNVRELESAVKLAVALSDGHDIDVRHLPETVQHALRQPPAASRPVAQPSLSSPTTQPDRARFAAAAAPSSRLGTPTEAELREILARHRGNIAAVGRELGKERMQVHRWLKRYAIDINDYRG
>NZ_CP011125.1|WP_157069132.1|4205367_4205907_+|hypothetical-protein
MRRIVTVLGALTVLLVASGCGRRRTEERVQVDVSQGGATSGGQTVYVVGAPAQGAPAAPDFVAQHMNVRYQQFAPDMVPDTPLYHGYLQQGQEESFEAVLEAGRCYRLIGVGGPTMSDLDLFIVDENGNPIAQDTATDNFPVLGVGQDTICPRWTGPFFVRALAYSGYGEYGLQLFRTP
>NZ_CP011125.1|WP_083457454.1|4205914_4207303_-|response-regulator
MNPVADDSLDWLAGLGLVVIEERLDGSARSIGPGGASIIERFDVALARATHLTGSDARLGALIRQARASGAAMVELAGARIGLHRRGDRLLAIVVPQDRTSASIVHELANALTGIAGWTRLATTAGPMPERARSAVEVLDRATNDALDTARTLLASLQGHAEIGEGSDVSDVVGAAISMLRPLSDDKDIVVRAKLPTGLRAAARPAELRAIATNLIKNAIEALEPGGEIVVAADAADDRVVLTVVDDGPGMDDATLAHIFDPFVTHKASGTGLGLALVRDLAQARGGDVRAESGRGRGARFVVRLPALLDARAEARERRQNLRGSGVRRRSTAPLKRPIRVLVVDDDESLRGMVTATLEIRGASVVAVPGVHEAMAVDQTFDLALVDLSLRDGRGDCLLAWLREQHRTHRAVLMSGAPVTPDEVTHADEVLRKPFTLEDLAEVVDRVVRAGARAPRDRSRGA
>NZ_CP011125.1|WP_053233670.1|4207394_4208666_-|metallopeptidase-family-protein
MRRRRVVLPSGLEVHVRAPEGAVRDDDVVDGTRLRFGRAIATLLAPGVVEGADVLALAMRDFHVLRDLLLRTGAIAPEPDDDARCRNCDAPLAFDPRELDPIELETAHASAPSPSLDPAPLPSPVRLPRGGIANEITMRPVTLREARPLLEALARDTPYRVTPRLLTAMGVLALGTLDRPVLMARVLGRASDAVWASVEQRYLELNAAPPLVAPLACPACGTLHEVVVPTPDELDPDATRTERDTGAPFLSEHEFERLVERLAPAIYEARGVRIEAVPPRVEPGVPATDIAGEPLLGSYEPRQEVDAAGYTQLEFVVTLYYRTFRRVWEDEGSYDVEAEIRETLDHELEHHLHHLAGHDPMDAAERAEARQELRALYGDRRLAKLAAREAARDLGQFVRVTWPFFVLIALALGAAAGFGWIRW
>NZ_CP011125.1|WP_157069133.1|4208675_4208969_-|hypothetical-protein
MSRRTSDISPERAASLSRHRTFRWNDGVDVNVYDAVETCDEGLRWYRWSHRFGERGGRVDEALQTFDAFLRDGPLRPAPATTVSAIRAWIDTNVAHD
>NZ_CP011125.1|WP_053233672.1|4209042_4210149_+|hypothetical-protein
MEKPPARVPPPLPPRAIPRMPPPPLAGLRGGAAQAAPAPPPPQPFAQAASQAPPGSTRAMILQAGAALRLRDEQLRARVQYYNAELKTNAELDAITDQVVAELRALASAQAGTRPQGEVEIELIQNLRELLEKLFSKKRSGFLTRKLEEVQRRITQLFFNSELYARLAEDGRELPAATWPEQALYFALKQHEIDILAELESMPVSEPAVRDRAIEKLQSFQRQLCNEFLSKTTPELERLLAIYREVLTHFFLEVFPKNLGEFCWEVVRESRVAHDHDLGYKITAEKFHGFRAVFDRKFLEHLVLNVQEPITRRASQSTEQFRDATLLFVQDPRIHTEICGAINDALYDYLHGEGYLDLPPDWRRLLMR
>NZ_CP011125.1|WP_053233673.1|4210145_4211555_-|hypothetical-protein
MRVLVPLAGVVLIALHASLYAGYVIDDAWISFRYARHLAHGLGLVFNEGERVEGYTNFLWVVLAAPFTSMRVERVMAGIGLACACATLVIAVLRARRDDPSARFAGVPTALGLACMHGLAFHAVGGLETPLYALLVLVASLMLADGRALPFAIATTLAFLTRPEAALLGLGGTLFLAHRSKRDGALALGAFVLLVTPYLVFKLAYFGALLPNTLHAKPPGLVSGARYLARELLPAIALVVAAIVGARTNERHRVLVVIALAFLAAVLLEGGDWMPGGRMIVPWLAPLFVAADRPIRALFTSTHRARVIAIVAVLAIVPWQIARSAELVMGTRARVPIDAARIELADRLAHEDVRSIALLDIGLVGWRAEHARIVDLGGLVDRTIAASPGPHGAKRADLDYLESLAPEVVILTSARDATRDAEGRVHVGARFVAEQHLEESAWLREHYEHVETRTPARVYRMHVFRRRLD
>NZ_CP011125.1|WP_157069134.1|4211570_4212866_-|TonB-family-protein
MTRSARAMSYGAAVSLLAHLAIAWLLPTLSATRTDAADAPAELAIDVRFSDEAGDGTAVRVPGAATPLEPGGADPEHNVDARDRGQGGDRTGAQRVIRLLPRADQVTLSDAPMNALGVGQTQRIETARDRATREDRRATPHPADDPFLASGDGEHPERRPVARVDAAPGARVAPEAGTRGAPIAGSERVVTADSGSTRGGTNEGALTTEPSGAASDSPGRGIVRGRGARATESARVALGRPTVDEAAAATPSESRDARVRDDTDAELLAARMMQSVVESTQRRGEEDGEGRGGARGLGAPGTGGGRREGGRARALGPGDGAYDALDTSDGRYRRWFVETRRRIENAMVFPRERAMRMDQGTSVVELVVRRDGTLARAPRVVRSSGFDDFDGAAIAAIRSTIPFSPLPDDLVPGRESLRIRMPLEFSNPMVR
>NZ_CP011125.1|WP_157069135.1|4212935_4213739_+|hypothetical-protein
MPTDILDRPELDGAVLRAPILDAPSTVALAVKLLARVPAPRDARDRDALARVRSKARTLRAAVLELQRAWAARDDAERREKGRTKVRPLDLASDAAWASLLARLEAWSGIGAEARAAELMALLLPTRLDFTRLALPAQWAVQQQKLDLVEAEGLARDLERLAGAAFLRAVRDTHEALGVALGMRGDAPPEPPIADVLQAMRAVHRAIGAYALRLADVYDDVSDEAAAAIRMALAPIAEARAAAATRPPSEAGEAGGPDTPVPDVDDA

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Crispr_ID: NZ_CP011125_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_20

4502237-4502528

Orphan

Consensus_repeat	Method
CCGCGCGCGACGACGACTGCGACGA	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP011125_20

>merge|NZ_CP011125|20|4502237-4502528|CRISPRCasFinder
CCGCGCGCGACGACGACTGCGACGACAACGACGGCATGGCGCACCCCGGCGGCACCGAGGCGTGCAACCGCCGCGACGACGACTGCGACGAGACGGTCGACGAGGGCACCGCGACCGCGACGCTCTATCCCGACGCCGACGGCGACGGCTGGGGCGGGCGCGAGGGCGATCCCGTGACCGGCTGCGATCGCCCCGGCTACGGGGTCGGCAACGACGACTGCGACGATCGGGATCCCGGCACGAACCCCGGCGCGACCGAGGTCTGCGGCGGGCGCGACGAGGACTGCGACGG

>NZ_CP011125|20|16|4502237-4502528|CRISPRCasFinder
CCGCGCGCGACGACGACTGCGACGA	CAACGACGGCATGGCGCACCCCGGCGGCACCGAGGCGTGCA
ACCGCCGCGACGACGACTGCGACGA	GACGGTCGACGAGGGCACCGCGACCGCGACGC
TCTATCCCGACGCCGACGGCGACGG	CTGGGGCGGGCGCGAGGGCGATCCCGTGACCGGCTGCGATCGCCCCGGCTACG
GGGTCGGCAACGACGACTGCGACGA	TCGGGATCCCGGCACGAACCCCGGCGCGACCGAGGTCTGCG
GCGGGCGCGACGAGGACTGCGACGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053238866.1\|4502900_4503758_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP011125.1\|WP_053233899.1\|4493280_4494855_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238867.1\|4507266_4509639_-\|arylsulfatase	unknown	unknown	gnl\|CDD\|293749
NZ_CP011125.1\|WP_053233906.1\|4500336_4501503_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233900.1\|4494895_4498531_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069174.1\|4491149_4492877_+\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NZ_CP011125.1\|WP_053233919.1\|4511569_4511794_+\|DUF4266-domain-containing-protein	unknown	unknown	gnl\|CDD\|379460
NZ_CP011125.1\|WP_053233910.1\|4504172_4505051_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233917.1\|4510793_4511573_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233911.1\|4505096_4506050_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069175.1\|4506309_4506915_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233915.1\|4509715_4510705_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378890
NZ_CP011125.1\|WP_053233923.1\|4513188_4514346_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053233895.1\|4489730_4491137_+\|RNA-directed-DNA-polymerase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|239569
NZ_CP011125.1\|WP_053233904.1\|4499200_4500340_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224001
NZ_CP011125.1\|WP_053233902.1\|4498540_4499131_-\|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|223632
NZ_CP011125.1\|WP_075097558.1\|4484405_4485146_+\|macro-domain-containing-protein	unknown	unknown	gnl\|CDD\|394872
NZ_CP011125.1\|WP_053233892.1\|4485173_4487705_+\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|224331
NZ_CP011125.1\|WP_053233893.1\|4487701_4489438_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069176.1\|4512054_4513185_+\|DUF3570-domain-containing-protein	unknown	unknown	gnl\|CDD\|378811

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053238866.1\|4502900_4503758_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.01097e-10
NZ_CP011125.1\|WP_157069174.1\|4491149_4492877_+\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.91561e-53
NZ_CP011125.1\|WP_053233895.1\|4489730_4491137_+\|RNA-directed-DNA-polymerase	gnl\|CDD\|239569	cd03487, RT_Bac_retron_II, RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA branches out from a small ssRNA molecule via a 2'-5'phosphodiester linkage. Bacterial retron RTs produce cDNA corresponding to only a small portion of the retron genome.	1.67517e-87
NZ_CP011125.1\|WP_053233904.1\|4499200_4500340_-\|hypothetical-protein	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	6.38421e-05
NZ_CP011125.1\|WP_053233902.1\|4498540_4499131_-\|CDP-alcohol-phosphatidyltransferase-family-protein	gnl\|CDD\|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	2.09191e-14
NZ_CP011125.1\|WP_053238867.1\|4507266_4509639_-\|arylsulfatase	gnl\|CDD\|293749	cd16025, PAS_like, Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	0
NZ_CP011125.1\|WP_075097558.1\|4484405_4485146_+\|macro-domain-containing-protein	gnl\|CDD\|394872	cd02900, Macro_Appr_pase, macrodomain, Appr-1"-pase family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. The yeast protein Ymx7 and related proteins in this family contain a stand-alone macrodomain and may be specific phosphatases catalyzing the conversion of ADP-ribose-1"-monophosphate (Appr-1"-p) to ADP-ribose. Appr-1"-p is an intermediate in a metabolic pathway involved in pre-tRNA splicing.	2.59915e-38
NZ_CP011125.1\|WP_053233915.1\|4509715_4510705_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	2.52486e-23
NZ_CP011125.1\|WP_053233892.1\|4485173_4487705_+\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	0.00010652
NZ_CP011125.1\|WP_053233919.1\|4511569_4511794_+\|DUF4266-domain-containing-protein	gnl\|CDD\|379460	pfam14086, DUF4266, Domain of unknown function (DUF4266). This presumed lipoprotein domain is functionally uncharacterized. This domain family is found in bacteria, and is approximately 50 amino acids in length.	9.1689e-08
NZ_CP011125.1\|WP_157069176.1\|4512054_4513185_+\|DUF3570-domain-containing-protein	gnl\|CDD\|378811	pfam12094, DUF3570, Protein of unknown function (DUF3570). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 396 to 444 amino acids in length.	0.00128772

>NZ_CP011125.1|WP_053233906.1|4500336_4501503_-|hypothetical-protein
MDRTTTWVCAAMVVLAGCAAELDEGEANDGGPDGVIVIDDAKLDALSEARVRAEGLTVWIDPAIDGRVEGGVGRFVIAGRASRDVLEVTSARGVTRVVSARRFEVELDEDEMSEVVMGMPLRVALRAARAPHARYVVRLRVRPRIGAGSGEREVAIASGLSPVWIDGGARYRGAVTLGRALSEPRMIAPSGGEIALVGEMPVLRFDLRYDDVARAASDRSARLVVTARRRSGIVRRTAEVELVVSELAITHHDPDAVWPDDVCAADVLVCLEDAGRDTSVCGDAWRVTRCRLPSRFVGDLRAHLIEWYAVHEGDVRAAGGATLAEAQRAIEASRVEELRHTDDDPHGHDRATTRVLRHPDVVFPGSDRVWHGAYARESGDLLEIYAFE
>NZ_CP011125.1|WP_053233904.1|4499200_4500340_-|hypothetical-protein
MSYTERVRHHVYLVPGFFGFANFGDFRYFAHVREHLLAWTRMRGVDAVIHYAPTFPTASLRRRAGRLVEIMAETSGDGGPIHLIGHSTGGLDARLAVAPRASLHCAVDPESVASRVRTVVAVTSPHYGAPTAAFFTSLLGQRLLFLLSLVTIYAIRVGTIPLPALVVLASALGSTGAGRLVAGGVIEQVYDLVIKDFSPERRLQIEQVFAQVRSDQTLLVQLTPEGLDLFNALATERDGVRRGCVVAQAKPPTLGRQARVGPSPTNQAMYNVYRALYAIASSLPEHLLPAPDDAQAKVLIDAYGRIPSAKGNDAMVPTRSQVWGEVVHAAWADHLDVIGHFHAPHRAPLHVDWMRTMSDFGQREFEEMWDDVARFAFST
>NZ_CP011125.1|WP_053233902.1|4498540_4499131_-|CDP-alcohol-phosphatidyltransferase-family-protein
MSHGTETSLLRELARPWNLMSLVRLPLAVVALLVRAEPLAVLALMVVAGISDALDGVMARRAHADPKLGEWLDPVCDKVFVLAVLAGVWIERQPPWWLLVLTATREILVVPAGITLAVSVGTFRSRIEYCARPSGKATTVAQFLVLGALLFDVDQVALPAAIAAAVLGLAAGVEYGVRARACLDAPRGTPAAGAAE
>NZ_CP011125.1|WP_053233900.1|4494895_4498531_+|hypothetical-protein
MDPIQTLTRAMDAVAKAVDHRDHEPDPARADWPRLRNHVTELRRRMEDEVIASFATLAIELPPGAREKVADNVAFLAIELSAIVRASADESGAVRLLRAAHKLGPRGLVAEELEGAMREPATHLALCRARWNHRQGDFDVGDRILREARRTAKDAGLRKLIETVLNGSRPLTNGAPALFRVNGFGVGIYGERDRRDDGSYVTTHCISALFVPIFPLGAYRVIDQGHGSYLFLSKEPLSAFARGWRWALLAAVVLGVVSTAVSSYLSSPSRLAAIALEDARAVDARGDVDASLAAYDGLLAGAGYDLDLADREAVGVRYVDVLASTVPTPLTEDRLDAFDRAMTRWQSVPQYARSGAPERHLQERVAAWASELGERDERSLRAALTVVERGIAVTTPSSPLDARRSALHRALGERLAPEWPFEALDEHVASGLDEAGVRAAAPIVERVIASPSLVLAASRSLRAWASAARMDTLPLRDRVSDALAAADAMQADAERAAALASGDEALLRASLARFPDDHDCVAALADLSRARGDSAAATATLRALGSPGVLAPTALASLAAAELDVGHLDDARALLARRVMPRLGELREAQQAMSRIERERTESLVSRLEMGLGPPEVQARLRVASDDETRAIVSEHLASELSRDPELGAARARYEAIAPIVPSVLQLAMIELRRGGERSGAERDRALADAERLFLAIQAEAASVPAYHLGLGQVYYRLGREGQGEQELQSVLASGDEDLALQVARAYRELGLEPRAREVATGVYERGQQPQAGRAAMLLSILADRIEDTETWLARAPQDTPEVRTRLTDVRGQRALRERRYDDADRLFAEVARDWDRAGDRDMPALNNAAVALGARYEATADPSHLDAALDRLERAVRLAPDQSITISNLADAHRFRGTLRVLSRWLDGRALRLDRSQADALLGIMTAGAHRAEVIAALRDDPGIRRAIELTHQEQVLAPRRAGAWERELALLRRCGDPSALVDLEARIARVGELEVNEQRAAWERGEWDAEILVHAERALADADDRLARARRGRDPRAVAALLTIRGNALLERATVRAESRDADVDLAIAAYREAAAAWPELGASSMLAQAHVTRALLRDASLRVRWEAERRRFSVVAILHHASNDPAQAAQVRASSDVRDAVAALSALDPVVLRVDELWIAESAADAAMIARLAPVRAREDLRAAYAIDRRLDPSDSESDERLATLASR
>NZ_CP011125.1|WP_053233899.1|4493280_4494855_+|hypothetical-protein
MVTQSAPAWTRAERISWALAGVALAAACIAHASFGYSHSDLSGHALGSDDAFISFRYAERLLAGDGLVFNAGERVEGFTNLGYLLLCVPGLALLGRDGVIAWAVGLNLLAALGAAALVASWLRRVLPAHLRVIAPWVVAIQPALWIAVASGLETPVVVLLQVALWRIVDAMAERDRARPIELVAMASIAICAVLVRADGFIGVGIAVVFLALRRHFGVAGALAAAGALAFAAVLAFRLSYYGDVLPNTYYAKVSAPFWMRVPAGIVQLGIVATQQGFALELVAIGAAWVLARRGGRLVPSYAAFLGAGVVAYWVWVGGDVFQERFLVGLYLVGSALALSIAASTSRLARWTPAIAGALVLVHLLPCVFDLRFRYTTTRTDRWVALGRHLAEHAPEGATIAVDAAGKIPFFSGLRAIDMLGLNDRELAHRERTRFDVGHDAYDPDYVLGRRPDLVACWIEPDLDMFYGLDRARWQGAGYRLRWLVFADENEHGRTEILDAREVPGALVPALIRAGFRYAVLDRAP
>NZ_CP011125.1|WP_157069174.1|4491149_4492877_+|ADP-ribosylglycohydrolase-family-protein
MGERRGSGDGTMQLDLLGAEVARPTKSSPGTVVADAPAKVTSSTHPMRVTWVEPRIGVAHAPGVVEIAETGIEWSRDLASDLDALRAEGADVLVDLTTDEERARGGYGAIEDLADERELVVIRLPIVPEGAPCEDAHEVLERIESHVSEDAKVVLVSREGMGRAGTIAVALQVRSGRALDDALRATRELRGRKVASSDAQREWLEQIAQHVASASAIDDGEEGDLWSARELDDDDLGPELPEAAIRETIPPEIRPATPRARALSPRASAVGGAVLGAAIGDAMGHPTEFMSLEAIRRKWPPHGVTAFELYWERGGKRFAPYTDDTQMAEAVLRSLLWSRREGADLDATMQHMARAFVEWAERPQGGHRAPGNACLSGSRALARGEHWSRAGGPTAGGCGSVMRAYPFGLLYAHDLSRCEEWSVAHSKLTHRDPIALAASAAMAIGVARVLRGDPTRVVLSEMIAAAARYSARTAVMMAEALDDADGGVAPETTLDRLRGWAAHEAIAAAVYLFARSPDDPERAILEGANSPGDSDSLATLSGALAGARAGLGALPDAWVRDVERSDDLLALALEI
>NZ_CP011125.1|WP_053233895.1|4489730_4491137_+|RNA-directed-DNA-polymerase
MSDEKDPQKAALVKAVLASLDDATALSRMKTLGFWPVHEPVPGDPPGEIVERAELDAELATLVKIASDGEKPEKALQRERIRRWKESRERRKAKKAERIAEAKQRADAWRAQRAERLVYAGLGVSAGLHDVESDVATLEACGLPIWRDARDVASALGISIAKLRWLTFHRRGATLVHYHRYGIPKKTGGIRAISAPKPALAEAQQNVQSLVLQRIAPSDEAHGFVRERSVVSNARPHVGRAVVVNLDLRDFFPTISFRRVKGLFAKLGYSEQVATVLALLCTEPPRVPAELDGQRYHVALGARVLPQGACTSPAITNLICRRLDARLRGIARALGFTYTRYADDLTFSGDDPTKLASLFGMVRKVIASEGFAEHEGKTRVMRRGARQEVTGVVVNRAVRLPRDEKRALRALLYNCARFGMESQNRDGRPSFASYLRGRVAWAVMVEPALGPRLFPALERALEGRRSDL
>NZ_CP011125.1|WP_053233893.1|4487701_4489438_+|hypothetical-protein
MTATSFAYKYAGRSGAVASGDRARLALATSTLREATYFAGELDDVLPLREGLAALYDVAVSDFRYHPRDRTAFRAWLAEQDRLFLAGLAAKSTHAKARLGEIQLRIGELDRARAERRASFEKARRAYVQWAIEDELERSLVLDPVVTVHPDELSFEAFSRDQSSYARLAVGHAAFSRIDAIEHGTTNVDFSSRLHDHFDRMRSYRATRFEIAPGGFEAETIAALPETARSVHEKKITMPEGWLAGFLQVHGLMSMGLERVELAPVDVYNVIRVIRARRAQASPRSLRWQLTPGERTKILIEPFDVLVTGSPISRFHGAKERSIRTWGRDRLRVLERVLPLAERVQVFLAGSGLPSIWVCDLGGRVTFTLALSGWTDNDWAGGQAKFDLLTRRLPTNADELTRVYGALRDARRATDAEIAARCDLGVEKARSALSILAQAGRAMYDVVSGLHRHRDLLLVPFSASAAIAEAKVAEIESSPKAKTAKEMIDHGGVRIIARRPTSMGYKLSGSARGESGPPVRPLLAVDHEGQILEASCTCVFAEKHGLTKGPCEHVLALRLAHMAKLEEEDQAKKKGSSS
>NZ_CP011125.1|WP_053233892.1|4485173_4487705_+|HEAT-repeat-domain-containing-protein
MIPTRRFRRPTGDDRYAVVSVEPSSAQPGAGSLQGQWLIRVARGIAPGSLSSGTVYGPYPTNLADARAEDVVRALLGEGFTPSVHEELIEALSSSDPARRARAAIALGWRRERAVVPALLAAAATKGPELPSIVEALGRIGDPAAIPITRELASKKLLSRRRAGVEALRLLGDAEGLAEARAAGQKRLPPSIAQAIGALDENDLRKSNVAPLLEVIDALEKARVGIVADQLYEAGTPALVATARRMLRASDVSAPHVWRYAKSVLKRAMLREDAATFALIAHAIEQRARSTKGKSASLKSGLDGETRSTRVFGRKTQRWAMRACWRYLRRIAKWRPERYAEIAAEVLCAYRPEDRAPEQGLFGPLAHSYELQRILFARSTRVVLDDRTLKTRFASAAAKMAVASVREEAFPELWDARPDAYLRALVGGRLREVQDFALAGVARHPGLAQRLQNGDIASLLASEHEGVVAVALAELERRFDATKPDLALLSRLLDSESASVRARGAALLDRSRLAWSGDPEGVLRLLDRERPVARAEIASIVASALRDAARDARMAIAKRLVDRLREGGDDDRLASIAELLASALRDEVASVLSSTELIAWIDRGGNAAKRVAGRLLAGRPEALALIGLPRLTALADSEVATVREAAVALLDAAEGELRADPTPLYTLAESRWDDVRRPALARLRALITVEQHGLDAVIALCDSNHAEVQALGRELVLASFDRLDADAVLFRLIEHPQRAMRAFAMELATQHLRPGYVPLARCEAFFRTVLLEVRADAATKRRAIDFLVTRGQLDAQQGALAASLLDRVLRTRTVRDFERVIVGLAAIQTRFPEVRSALSTEGA
>NZ_CP011125.1|WP_075097558.1|4484405_4485146_+|macro-domain-containing-protein
MLVKVVLCDVNPKVIQAWRATFEENPEVEIVHGSMLDMSTSAWVSPTNSAGRMDGGLDLVIKNYLGVGIEKTLQRTIKDRYAGRMPVGHAACTPTERVQPRFLISTPTMVSSSEDISATMNVALACAAAFQAVHIQNTVEPGTIRSVALPGLGANTGRVPAEICADLMWTAYDLFREHAFTDFAAVRQALESILGDLGPTSTQYKQKAAPGLSQMGITPSKPTIGGALEDFDDSEFEDDEDFSDDE
>NZ_CP011125.1|WP_053238866.1|4502900_4503758_-|alpha/beta-hydrolase
MDDTSFEPARRGRTRLPSGRFLGWSEQGPEHGAPVLFFGGAGTSSALSMRREDVERAGVRLVAVDRPGLGASDPLAGRTLADWVEDVRDFVIARALGSPAIVAFSQGAPFGIACAADEIGRSLVIVSGTDELAAPHLAELLVPDVRGIVQRVARDPEGAEAFFRGMTPAMMRQMVLAMIGDADRAVYADPAFDAAYRRALDEGFAQGGEGYARDTVLAFGAWPFDLGRISMPVSLWYGAEDTSPVHSPDLGASLAHRIPSARRTVIDAAGGAILWTHGEAILAAI
>NZ_CP011125.1|WP_053233910.1|4504172_4505051_-|hypothetical-protein
MATSKKTTRKATTARPSPTVQIAERSLAALAPLREPERAAFLAQTTPEDRAALGARTRADGVLRDLGPLIAHIDASVAKYGTTIRYGAPRRAFLAQTTLELADALATATGKRDGATSASAQRNAALRRGRAVFGDLAHALSSIARGSAEAARLDAVERDFDHEDTLARGLRQLAELARGWIERARTDEAARALVAGAHLTEADVTSAERAAEALLTAGADRVGSGRASANDPPEVNVLEGIVLAEAREAWRAFEAARSNHPSIPRLPLGTALRQVIGTRPKRAKPKPAAPKT
>NZ_CP011125.1|WP_053233911.1|4505096_4506050_-|hypothetical-protein
MLLAAGSALAQTTPLPAEDPHPTARSARSVGGHAYSEFENIELPFVATRVTSRTGIGVSQFELRGERVPRRDLEGDLAQLDQRFVLGIALTEWLGLEVGVHGGAIGGIDYDAGLVIGANGFGGGRLSGVVRVVETDAFLLSLRVDVTAGAAAGIAPARTVIPLLTGQRPPESRLRSPDFSGSRGTLGGSVTGVLTATEWLGFAGSFRAEARRVEFDDVEDDEGWLGGALGASFNFGSLGVPLQILLGSRVSWSFADEIDDLALSIVEPADEVVVEPELGFYYFDPKLPELEVGLSTSFAFSDETRRGRVGLNLAYWF
>NZ_CP011125.1|WP_157069175.1|4506309_4506915_+|hypothetical-protein
MRRPVEWVLSAALIAALAGRARAQEGSPDAHAPADARAAAPATAAQPPQPTTVPELAVPVFGLGTQVVLLAPAPTAGAGAFAATYDLGVLHVDALLGVFLSDAFESSVRGTVRVFFPVHRGPIADFSLGVGGGVGYIEPAGGQLQVLGEALAGAKIRSFIGRNIALEATIGANLLFMDGDFESVSIGGRLLGAAGFMYYFR
>NZ_CP011125.1|WP_053238867.1|4507266_4509639_-|arylsulfatase
MASDYDEYEPGKPFPGRIGMTVDESTPAWPAYRRAKDGAPNVLIFVLDDVGFGQLSCFGGLCETPNLDRLASRGLRYTNMQTTALCSPTRGALLTGRNHHTLGLSAITELSMGFPAHNGMVGFEHGFLSEMLLEHGYNTFAVGKWHLAPPEETTQAGPFTRWPLGRGFERYYGFLGGDTDQWHPDLTEDNRSVTPPRTPEEGYHLNVDLADRAIRMIQDADASAPEKPFFLYYATGAGHAPHHVEKSWIDRYRGRFDMGWDAYREQVFARQLELGVIPAGTTLSTRDPDVPAWDTLSADEKRMYARQMEVYAAFLSQTDHHFGRILDYLERIGELENTLVVAISDNGASAEGGVHGTFNEMLFFNGAPERLEDNLRHYDDWGGPDTFPHYAWGWTWAGDTPFRRWKRETYRGGTSDPCIVSWPRGIPASGEIRTQYLHVIDIVPTILETLGLEPPSTIRGVTQSPIEGVSFAHTLHDAAAPTKHVTQYFEMFGHRAIHHDGWRAVCPFPGPSLTEGASRGWLFGRTSLTREVLEELDRSGWELYHLDEDPSETRNVAAEHPEILRSMTRRWYVEAGRYGVMPLAAGDVARMNVPRPTVARPRDRYVLQPGGAPIPFAAAPRIYNRPHSITAKVRIPAGGAEGVLLAHGNRHGGYSLYVAEGRLHHVHNYLGLHKMKVSSNVVLPSGEHTLRYEFEPTGAPDLAAGKGVPGRSQLYLDGRLVGSAMLPFTVPNVFGIAGLSCGRDHYDAVVPSEYRAPFPFTGELVEVVIDLSGELTRDHQRDIDRLMAQQ
>NZ_CP011125.1|WP_053233915.1|4509715_4510705_-|AraC-family-transcriptional-regulator
MPSTVRTDAVEQILAIAERAGLDRAALLARARIPGDVLRGGGGRIAVERLHALWHAVTRDAGRALTSKVAAHARVEGFGPYGFSILTAPTALDALRTATEHYPVINDDGRWSVELGASRVVARWARAGAATAGVDAASESIVAHFVLGLRSIVDGPIRVDEVRFAHAAPRGVRALEEVLRAPLVFDAGENAIVLPRADLDAVPRLASAPMHAFVTGFVRDELARIAPERTFVDHVADALAARPDARASRIAAELGVTERTLRRRLADTGTSFRALVDARRAAIALDRVEHTDDAITRIAIELGFTDASAFARAFRRWHGRSPSKVRDAR
>NZ_CP011125.1|WP_053233917.1|4510793_4511573_+|hypothetical-protein
MKTDCLLPIAVTLALSLAHGGCVDPESVPPATRSAGGEAAARRALVVVPYGAPDARRGDAVVHLFVEGAPTAGDACAAPACVALRSGADGALVAELAAGARLAYRVMPDASFVRTIASGAVVEPGAGPLRLHTVPRVVLAAMFRDAGVTAQDGRGHVAGVVRGADGAPLAGVVPRIVDDAGREITAGSLLVSPSDVPGALTSGGTETSSSGRFAIVNLPPSGSLRVEVWRASERIASERIPVEADALSIVSLRASEAAR
>NZ_CP011125.1|WP_053233919.1|4511569_4511794_+|DUF4266-domain-containing-protein
MSARGVVVVALGIAWAASGCVVVPAYQRGAFVDPAMDPASRALAVRSRRQLYTSREAAAGGDGTSAGGGCACGN
>NZ_CP011125.1|WP_157069176.1|4512054_4513185_+|DUF3570-domain-containing-protein
MRGSVSAALLVVLLAVPGVASSQDDEGLRFERFEARFATFVQRGAGWQSQASDDPRAPGSEALEVYQPALYARLREGRETVHEITVPIDVVTSASADALDAVSTASLVNEAVGLHVAHRFALDADTRVTARWGGNVEETLRSGTVGLSIARELAEDNATLVVSADVIADHLDRILPNGSTPEERGRVAATFNVSLAQLLSPTTMIELAGGATLQAGELATTWGSVPTLAGGRAAEVLPDTRARYAVRATLRQAVLETMTFGEAAYRLYADDLGVVAHTGELGITQYVIPGTLWIRADARVHTQTAPWLWTSLLQDDGAPGPRTADSDLAELVAIEGGGALRWIYDRGSWLELEGAHYVRTNGLDVTRVALTWGQAF
>NZ_CP011125.1|WP_053233923.1|4513188_4514346_-|hypothetical-protein
MSRPAPSQAPRGIAPELLLSQVRNTAPYVFDEGVIDTPPATFVRELDRAMPASLSHAEYFRLCVSAHYLTCATPVPTDVDNQIRRKLWAPGLPLVTALEMGRLVLESRGWDFTPLTSRASYGAKGTEWEHVPLHGHAGEWFTVAAGAYAALGQYRAADAKTLRASLLEAIARETEQHSQIFGSLWRAKDGVGALLASVSIAHNFGDLDRVIDMWDLPITDPLRRDFHGLTTSPFDAERNLRHMGRLWTAGELYKSVIDGSSMALENHRHFALRKPRGLRARPELRVPLGPFFDAWGARVATMLEGESLLETIDALVAGCERMPTTAGYARALHAIREARPELHERSDALTKSAHFRALLETPRDVFEARWNDAALTLLDEIPGRA

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Crispr_ID: NZ_CP011125_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_21

6131044-6131185

Orphan

Consensus_repeat	Method
CGCCGAGCATCGAAGATGCTCGATC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP011125_21

>merge|NZ_CP011125|21|6131044-6131185|PILER-CR
CGCCGAGCATCGAAGATGCTCGATCCGCGTCGCAGCACGGACGTCGTTCACCGTCGAGCATCGAAGATGCTCGACCAGAAAAAAGAGCTGAAGTGGACCGGACGACGACGGCTGCGACGCCGAGCATCGAAGATGCTCGATC

>NZ_CP011125|21|4|6131044-6131185|PILER-CR
CGCCGAGCATCGAAGATGCTCGATC	CGCGTCGCAGCACGGACGTCGTTCAC
CGTCGAGCATCGAAGATGCTCGACC	AGAAAAAAGAGCTGAAGTGGACCGGACGACGACGGCTGCGA
CGCCGAGCATCGAAGATGCTCGATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_157069389.1\|6131722_6132691_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379248
NZ_CP011125.1\|WP_053235312.1\|6137065_6138700_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367457
NZ_CP011125.1\|WP_053235301.1\|6121754_6122252_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235305.1\|6126006_6127224_-\|NADH-quinone-oxidoreductase-subunit-D	unknown	unknown	gnl\|CDD\|180385
NZ_CP011125.1\|WP_053235311.1\|6134673_6136950_-\|bifunctional-salicylyl-CoA-5-hydroxylase/oxidoreductase	unknown	unknown	gnl\|CDD\|236203
NZ_CP011125.1\|WP_053235302.1\|6122354_6122939_-\|NADH-quinone-oxidoreductase-subunit-I	unknown	unknown	gnl\|CDD\|235637
NZ_CP011125.1\|WP_053235310.1\|6132934_6134635_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235306.1\|6128591_6128951_-\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|180638
NZ_CP011125.1\|WP_053235308.1\|6131215_6131701_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP011125.1\|WP_053235304.1\|6124366_6125959_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|273904
NZ_CP011125.1\|WP_053235303.1\|6122943_6124356_-\|NADH-quinone-oxidoreductase-subunit-H	unknown	unknown	gnl\|CDD\|235692
NZ_CP011125.1\|WP_053235314.1\|6141853_6142438_-\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_CP011125.1\|WP_053238958.1\|6140836_6141145_-\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NZ_CP011125.1\|WP_169791554.1\|6121358_6121754_+\|DUF3634-family-protein	unknown	unknown	gnl\|CDD\|315081
NZ_CP011125.1\|WP_053235307.1\|6129520_6130921_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225243
NZ_CP011125.1\|WP_053235299.1\|6120060_6121269_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|99738
NZ_CP011125.1\|WP_075098015.1\|6138812_6140243_-\|replicative-DNA-helicase	unknown	unknown	gnl\|CDD\|273206
NZ_CP011125.1\|WP_053235313.1\|6141198_6141741_-\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|275385
NZ_CP011125.1\|WP_053238957.1\|6140377_6140821_-\|50S-ribosomal-protein-L9	unknown	unknown	gnl\|CDD\|234659
NZ_CP011125.1\|WP_075097626.1\|6127245_6127929_-\|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl\|CDD\|376317

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_157069389.1\|6131722_6132691_-\|hypothetical-protein	gnl\|CDD\|379248	pfam13540, RCC1_2, Regulator of chromosome condensation (RCC1) repeat.	2.25897e-05
NZ_CP011125.1\|WP_053235312.1\|6137065_6138700_-\|hypothetical-protein	gnl\|CDD\|367457	pfam03349, Toluene_X, Outer membrane protein transport protein (OMPP1/FadL/TodX). This family includes TodX from Pseudomonas putida F1 and TbuX from Ralstonia pickettii PKO1. These are membrane proteins of uncertain function that are involved in toluene catabolism. Related proteins involved in the degradation of similar aromatic hydrocarbons are also in this family, such as CymD. This family also includes FadL involved in translocation of long-chain fatty acids across the outer membrane. It is also a receptor for the bacteriophage T2.	2.83503e-07
NZ_CP011125.1\|WP_053235305.1\|6126006_6127224_-\|NADH-quinone-oxidoreductase-subunit-D	gnl\|CDD\|180385	PRK06075, PRK06075, NADH-quinone oxidoreductase subunit D.	0
NZ_CP011125.1\|WP_053235311.1\|6134673_6136950_-\|bifunctional-salicylyl-CoA-5-hydroxylase/oxidoreductase	gnl\|CDD\|236203	PRK08255, PRK08255, bifunctional salicylyl-CoA 5-hydroxylase/oxidoreductase.	0
NZ_CP011125.1\|WP_053235302.1\|6122354_6122939_-\|NADH-quinone-oxidoreductase-subunit-I	gnl\|CDD\|235637	PRK05888, PRK05888, NADH-quinone oxidoreductase subunit NuoI.	4.12863e-43
NZ_CP011125.1\|WP_053238958.1\|6140836_6141145_-\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	4.87505e-30
NZ_CP011125.1\|WP_053235306.1\|6128591_6128951_-\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|180638	PRK06602, PRK06602, NADH:ubiquinone oxidoreductase subunit A; Validated.	2.16379e-42
NZ_CP011125.1\|WP_053235308.1\|6131215_6131701_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	9.0641e-14
NZ_CP011125.1\|WP_053235304.1\|6124366_6125959_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|273904	TIGR01973, NADH-quinone_oxidoreductase_subunit_G, NADH-quinone oxidoreductase, chain G. This model represents the G subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria while translocating protons, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes related subunits from formate dehydrogenase complexes. [Energy metabolism, Electron transport].	6.41942e-100
NZ_CP011125.1\|WP_053235303.1\|6122943_6124356_-\|NADH-quinone-oxidoreductase-subunit-H	gnl\|CDD\|235692	PRK06076, PRK06076, NADH-quinone oxidoreductase subunit NuoH.	1.25422e-86
NZ_CP011125.1\|WP_053235314.1\|6141853_6142438_-\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	8.32452e-102
NZ_CP011125.1\|WP_169791554.1\|6121358_6121754_+\|DUF3634-family-protein	gnl\|CDD\|315081	pfam12321, DUF3634, Protein of unknown function (DUF3634). This family of proteins is found in bacteria. Proteins in this family are typically between 103 and 114 amino acids in length.	2.33574e-13
NZ_CP011125.1\|WP_053235307.1\|6129520_6130921_-\|hypothetical-protein	gnl\|CDD\|225243	COG2368, COG2368, Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism].	8.82488e-149
NZ_CP011125.1\|WP_053235299.1\|6120060_6121269_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|99738	cd00614, CGS_like, CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.	5.85559e-166
NZ_CP011125.1\|WP_075098015.1\|6138812_6140243_-\|replicative-DNA-helicase	gnl\|CDD\|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP011125.1\|WP_053235313.1\|6141198_6141741_-\|30S-ribosomal-protein-S6	gnl\|CDD\|275385	cd00473, bS6, Bacterial ribosomal protein S6. bS6 is one of the components of the small subunit of the prokaryotic ribosome, a ribonucleoprotein organelle that decodes the genetic information in messenger RNA and forms peptide bonds to synthesize the corresponding polypeptides. Ribosomes consist of a large and a small subunit, which assemble during the initiation stage of protein synthesis. Prokaryotic ribosomes consist of three molecules of RNA and more than 50 proteins. The small subunits of bacterial and eukaryotic ribosomes have the same overall shapes (with structural elements described as head, body, platform, beak and shoulder). The bacterial ribosomal protein S6 is important for the assembly of the central domain of the small subunit via heterodimerization with ribosomal protein S18.	6.62935e-32
NZ_CP011125.1\|WP_053238957.1\|6140377_6140821_-\|50S-ribosomal-protein-L9	gnl\|CDD\|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	1.70702e-63
NZ_CP011125.1\|WP_075097626.1\|6127245_6127929_-\|NADH-quinone-oxidoreductase-subunit-C	gnl\|CDD\|376317	pfam00329, Complex1_30kDa, Respiratory-chain NADH dehydrogenase, 30 Kd subunit.	2.23503e-55

>NZ_CP011125.1|WP_053235307.1|6129520_6130921_-|hypothetical-protein
MKTAAEYVESLRARKLVLWVDGQRVPDPTRHPKVRPSIDTVAATYALAHDPDPTIRDLATPHSKLVDARVNRFTHLFTSDDDLRKKLELQRILGRLTGTCFQRCVGMDGLNATYIATHGRQGHDRFVRWLANVQREDLTLNGAMTDPKGDRSKRPSEQPDSFVRVVGRSAVGLVIRGAKIHQTGAANAHEILVMPGQSLRAGEEDFAIACAIPVDAPGVSMVLGRQPSDERRGGPDAGNARYGGQECVVIFEDVFVPRDRVFIDGDLEACNELLEAFAGFHRASYGGCKPGNLDALVGATALLAKKNGVRDASHVRDKLTQMVHLTETIHALGLAASTKTTKHRSGIHQVDAVLANVCKHHVTELPYEIVRLAEDLAGGLLATMPSVADLDHPELGPKLRHVMGDRERAKLLRLVEWMSYGSGAVPLRIECMHGAGSPQAQRVVIERRTDWDEKMRAARKLAGLDE
>NZ_CP011125.1|WP_053235306.1|6128591_6128951_-|NADH-quinone-oxidoreductase-subunit-A
MFEVYFPVFLMLAIAVAIPSLLFILASTLGRKNPTPEKLIPYESGSATTGAQHVRLSVKFYLTAILFVVFDIEAVFLYPWAAQFRELGWFGLVEMLLFLLVLGVTLVYAWKKGALEWER
>NZ_CP011125.1|WP_075097626.1|6127245_6127929_-|NADH-quinone-oxidoreductase-subunit-C
MSKKVLERLTAQFGDRILATSSHFGDDEAVVAPKDWLEVARFLRDDPECDMNHFVDVTCVDYPMREDLPRFDVLLFVRSLAKKHRVRIKTRVDEGGSVASLVPVWIGANWGEREAWDMFGVVFEGHPDPRRILMYDEFVGHPLRKDYPIEKTQPLVPYRDVEDIDKLPPFGPDEGQPWSRIDWQARIEGSDFQVSPAIGEQQGQRPALSKGIEYTELDDEAARTATE
>NZ_CP011125.1|WP_053235305.1|6126006_6127224_-|NADH-quinone-oxidoreductase-subunit-D
MEPFYEDEEHEGTLELPAEPMRINMGPSHPAMHGTIRMVLELDGETVMDLDIQPGYLHRGFEKSCERGNWTQVFPYADRLNYVSPMLCNVGFSLAVEKLAGLKVPERCTWYRMILGEISRITDHLTCNSATAMELGAFTPFLWCIKVRDWLWDVLEQETGARMTHSFGRIGGMAKEPTPHFKESVRAVLPQVDEVLLETESLLLKNRIFLDRTQGIGKLSKERALAWGVTGPVLRSTGVDYDVRKAHPYMFYDAVDFDVPVGHDGDNYDRFMVRFEEVRQSMKIIEQCLDKMPDKGPINADDPRFVLPEKLDVYNTIEATIAHFKIVMEGIKVPAGECYSFTEGGNGELGFFIVSDGSGTPYRVRCRPPCFYNLQACREMLIGDMVADIVPTFGSINMIGGECDR
>NZ_CP011125.1|WP_053235304.1|6124366_6125959_-|(2Fe-2S)-binding-protein
MPTFKLDGQEIPFEPGDTIIRAAWKKGVEIPHYCWHPGLSIAANCRMCLVEIKSARPMALPILAWDEKKKDYVETTKNKLQPACQIEVTEGMEVASKGAAVEKAQGAVQEFLLLNHPVDCPICDQAGECKLQDYWLAHQKKLKRKDTEPVHKPKAVRFGPTIVYDAERCIMCTRCIRFCDEVVGDHVLDMRERGNKNEITVSPGRELDHAYTLMTEHVCPVGALTSKDFRFKARVWFLRSAPGVCNGCATGCNTWVDYDPRYQRVYRLRPRDNEQVNKFWMCDAGMMTYKRFHEDRILTGRVRQEGRVVEVPRDVAIEASAKVLEKSQRLAVVFSAQHTNEDNFVLGKLGREHLGGTALYLAALSPESVPGGWKGDAILRHPDPNPNRAGATAVAGGELRSTADLAADVAAGRVDAILSLGWAAGESVEQLASLANVPHVNLSSNIGPLTQVATVVVPVATTAEASGTFVNAKGMAQQFQRAVNAPLGIKSAWETLIEIGKRVGREIAFAKLPEVRAAMPATTAAVAAAS
>NZ_CP011125.1|WP_053235303.1|6122943_6124356_-|NADH-quinone-oxidoreductase-subunit-H
MDLGWLVLVSILKIAFVIGVLLLLFAPVLVLAERRQSAFFQDRLGPYMGGFPMPRALLDAIPYLVLGAYVVAALCGVMFAISLAMVATGNGQDVLFTEPVFGIEHTWGGLMLVFFPLAVIHLVAAKILPFLFFDGRLTIFGGLHALFDAIKAFTKEDIVPPRGDKFLHSIAPIIAMVPAFATAAVIPFGPTIYVDYLLDQLPAEGAIGGTAIDIQVANLNIGILYIFAIAGTGIIGAAIAGYASDNKYALLGGLRAASQMVSYEVTLGLSLVPMFMLYDSLMLPDMIRWQSEHVWGVLVNPLAFVLFFTATIAEYKRVPFDAPEGESEIVAGYFLEYSSGKWLMYMMGEFIEVAVSSAIIAVVFLGGWDVPFLTRAGWEAFGYRFDLSGTDFAVVSNVANSHLFIIILQVVAFLTKVMVLALISIQVRWTLPRFRYDQIMSLCWKLILPLSLLNILVTGIFVLLFQQMGW
>NZ_CP011125.1|WP_053235302.1|6122354_6122939_-|NADH-quinone-oxidoreductase-subunit-I
MAYAIKKPGRTVADQSYVVEAVKGLGVTFKRFFQNTIGPAENRKTATIRYPEESRDYPERFRGVHRLTHRADGSPRCVACLCCSTACPAQCIYIEPAEYEADDPRHGYERYPRVFVIDELRCIFCGFCVEACPCDAIRMDTGTHVPASWKREHFIFDKETLMSIPGKDGTYVTANPRHEPGDPTHPGLDREKAH
>NZ_CP011125.1|WP_053235301.1|6121754_6122252_-|hypothetical-protein
MSAQRIALGHGSAWHDFHRVDRERPYELAVRELVGASQRARVSIEDDLLHAWSAELSAIPCVWPTREIHRGLAWTGWSVIRGDGARVAHDVFRSLARRYRDDDGPPVLDVRLGEEHWIDDDGREHSLGDHVERVARADLIAAFERLAEDCLWATRAPGYLLHLGV
>NZ_CP011125.1|WP_169791554.1|6121358_6121754_+|DUF3634-family-protein
MLDPIVILVVLLVAVGAYVLWRANEIFCLSVRDGRVLVVRGRIPPALLHGIEDVVRRTGTRRATIRAVAGQHHARLVLSGTDDGTAQRLRNVFGTHPIQKLRGAKLPEARNLGQVLGIAWLAWLLVDRGRG
>NZ_CP011125.1|WP_053235299.1|6120060_6121269_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MSSDQQSKKQEPGRTPETRAVHGGEPRDRASDSLAEPIVQTATYTFASTSALVEYMEGKVEREEYGRYGNPTVRTLEQKMAALEGTDDAVAFSSGMSAVTTAILALVKSGSHVVLFSDCYRRTRQFVTSFLDRFGVTSTLVPPADVDAMQAALTPQTRLVISEAPTNPYNNVVDLRRVAAICRERRIRTMIDATFATPVNLRPAEHGIDLVVHSATKYLSGHNDVLAGVVAGPNGLVSLVRDLRHVLGGVLDPHAAYLVHRGIKTLAVRVKQQNASALALAQALEGHPRVRRVWYPGLASHPHHAVAKELMTGFGGVVTFAVKGDLASVGRFVDACRIPRIAPSLGGVESLIEQPALMSYFELSTEQREAVGISDDLVRYAVGIEDTDELVADVLRALDQTA
>NZ_CP011125.1|WP_053235308.1|6131215_6131701_-|PaaI-family-thioesterase
MSTPLPPLDGHLFGPGQPCFGCGPDHPYGFHLTFAREGDEIVTRFTPGDRYQGPPGIMHGGLVSTLADEVAAWALIGLLGKFGFTASFDAKLHKAVRIGVPLEGRSVITRDARRIVDVAVRIVQDGADAFTGSFRFVVLDQGGAERMLGGPIPDAWKRFCR
>NZ_CP011125.1|WP_157069389.1|6131722_6132691_-|hypothetical-protein
MDGTSSGCTVEETEAGAVVTCDDGTSVTVPRGVDGSGCTLTDHGDGSATLTCDDGTSVTLPIDGPLHLGAGSNGSCATRADGTLRCWGSAGILSVPPGRFVEVRGFHNDHRFCARRPDHTVACWGNPDPLSTPLGETFTRLYGHDRGMCGMRADGTLRCWGAFGPIDGPPTDEAFVDYAFGFEWGCGVRASDGTIRCWGGPDPDDVPTPPTGAFVSIVGSLFDVCGRRADGTVACSGALASGAPAEALGAISAGQLHACGIRASDASLVCWGRDAEGQHVVPPGRFVEVVSGGRHSCALDEADEVHCWGDDTFGQASVPDPL
>NZ_CP011125.1|WP_053235310.1|6132934_6134635_-|hypothetical-protein
MRAASCRDRAPIHAARARYAECTTRGPMGTRGKGRARWALVLIALASGCTGDAAIDGDASTPRDGGISSIDGARPSEHDASTSPIDGGPVATAGEIALTLRADRGAASDAVVSLGVPFAPGVLRDASHVRVLDASGTEREIHVAELARWPLDGSIRSVLVAFRATLAANAEERWTIEHGAPRTRTAPAAIAPAPDGPVAATLDPEHYARSRVSGPHLTIAANDRFESFDDELESCLGSMSPAYETYGVSCAGTNAHRTYYDGPHALWQRFVRGADAARYRRARLESTWYRDNELEWIAGRAMAVQVCQADGWTPSQKLDWGVMRRMTGQGMLDDYLLTGDPAAREAVIAMGEAFVRSLPAQRGGRENSLRVTERNLAWTIMGVASYYALDPRDEVRAALVSLIDEAVDWQSDGTSGAFEHDLVRPDPEECSDGPAGGSPFMTSLLVDGLMDAHALTGDARIADVVRRAAEWLRDDAVTSDGAAFRYLWGCASDDYDDSSTADLNLLIVHVFGAAYVLTGDAAWLDVGDAFADHGVDAMYVGRPKQWNQSGRAFPRYLGYRALGRAP
>NZ_CP011125.1|WP_053235311.1|6134673_6136950_-|bifunctional-salicylyl-CoA-5-hydroxylase/oxidoreductase
MRVRILGGGPAGLYLSILLKKHDASHDVQVIERNAPDDTFGWGVVFSDETLSNIEEAEPETFASFARDFARWDALDIRVKGETIRSHGHGFVGIARKRLLMRLQERARALGVELSFKTEVSDVDALRRDCDLLVGADGLRSIVRTRFEDAFRPTFDVRRARYVWLGSTQRFPAFTFSFRENEHGLFQIHAYQFDGCGSEAAHSTVIVETDEESWRRAGLEGASEEQTIAYCERVFADDLGGHPLLPNRSQWIQFTTIKNERWVHENVAILGDAAHTAHFSIGSGTKMALEDAIVLARAIAAHPGDLATALSSYEDEQRPIVGRIQTAAQQSLEWFEQAKRHHAALEPMQLAFSLLTRSRRITHSNLAMRDPAWVAEADRWFARRAGIDVDAKTPPPMFTPFTLRGLTLPNRIVVSPMCQYSAEDGLPDDWHLVHLGSRAIGGAGLVMTEMTDVSPEGRITPGCTGIWSDEHVARWKRVVDFVHRFSDAKIGLQLAHAGRKGSTKLLWLGEDEPLDDGNWELIAPSPLPYDETKSQTPRPMTRADMDAVIDAHVRGAKNADAAGFDLLELHMAHGYLLSSFLSPLSNQRTDAYGGSLENRMRFPLEVFDAVRAAWPSDKPMSVRVSATDWVPGAFDGDDAVALSRALKQRGCDVIDVSTGQTSTLAKPVYGRAYQTPFSDRIRNELGIPTIAVGNIQDFDQVNSILLAGRADLCALARPHLYDPYWTLHAAATQGHDGVRWPDQYRAAKTAIPKTVKPA
>NZ_CP011125.1|WP_053235312.1|6137065_6138700_-|hypothetical-protein
MSFLRASYSVLLCALVLSVPAGASAGGFEFAAHGTRQLGRGGAWAARADDPLALYYNPAMLADLPDSQVLANVHVGFWDACVDRQGTYGSVIPGGTASDNIFDSEGGNPDAWLGDEMPSVCNSGYPQPIPWVLGSIRLLPELGIAFGITAPSGIGNATWGNTGEGRFGTVDTANGLRPSPVRYGLAQQDVLLAHPSIGVGWRPADFIRIGFTFQWGIANVRFMNFTSAGVLGAPEDPFGDIRTELHAFDWFVPAGILSVHVQPHPNFDIMVGGRISDAIGGATAAEGHLDLNTSYFSRDEQWQSTPNRIDGVTLRAGQPWQFQLAMRYADRIRPRSWERGFEAAVQNVVNDSMYSENFDIELDVVYELNSQVGDFVVRLPTGASVIAGGTAVPVPAVQPIPHGWGDVLGIRLGGDWNIIPGQIAARAGFHTEIPLAQSRYQIQDFINGYRFGLHVGATFRIERFDISIAYAHIFQLDTTITDGNFRAVSANSSEGMCAGGGGYDPNNPVVDAGCYPQGYGAVTNNGTYSAEYNVLSVGATYHFE
>NZ_CP011125.1|WP_075098015.1|6138812_6140243_-|replicative-DNA-helicase
MFDEAGSGERSFSRGDSGAAGGRVPPHSLEAERAVLGGVLLENSALNTVTQILSGDDFYSRANGLVFDAMCELFRRGQPVDTVTLRAWLVDRGQHQKAGGDEHLLGLTNTIPTVANIEHYSQIVREKATVRRLITACHEIAATGYGDYGEPAEYLDQAEKRVFEVGKQHGSAPYEHIKDVVLRTFEQVQEAARRKEAITGLPTGLHKLDEMTAGLKGGELIIIAGRPGMGKTAFALNVAIAACQQRGVPIAVFSLEMRKEELVRRLLCSEAKVDGGRMRTGMLSREDWARLASSAGPLTEMPFFIDDTPAITLMQLRGKARRLKSENHGKLGMIVIDYLQLMRSGVKNDSREQEISEISRSLKGLSKELDCPVIALSQLNRGVETRPGKDKRPQLADLRESGAIEQDADVIMFVYRPEVYAKDEERAQLRGLAEIIVGKQRAGPTGIVRCRFFHEFTRFENLAEGEFEDYDGGGDE
>NZ_CP011125.1|WP_053238957.1|6140377_6140821_-|50S-ribosomal-protein-L9
MQVVLKDDVENLGKSGELVRVRPGYARNYLLPRGLAALATRGNIAQIEHEKAVATARAAKLKGDAEAVSKTLSGIKVEIAVQAGEGDKLFGSVGTKDIAEALEKKGQKVDRKKIVLAENIKTVGDHDVAIKLGYDVTATIKVSVVKA
>NZ_CP011125.1|WP_053238958.1|6140836_6141145_-|30S-ribosomal-protein-S18
MDDDRRGGRDDGGSQPPPGRGGADDPLGLRRRAGRKRAPAFTADPDFSFDYKDPQTLKHFITERGKIVPRRISGLSAKQQRDLTRAIKLARKISLLPYTGVK
>NZ_CP011125.1|WP_053235313.1|6141198_6141741_-|30S-ribosomal-protein-S6
MQQSAAATSKRLAREYELVYILTPNVDPDDADKVATRIQEVVARLGGKITKVDSWGRRRLAYPIKKSSRGVFVYVRYIGFNDLVAELERNLRNADAVIRFQTVRREGVFDLAEVTVDPEEAKFSRIEAAPLEEEPEPSFEERLGLTQKPREREEEDFLDMGDEDDVVPGAEKPEDETTEK
>NZ_CP011125.1|WP_053235314.1|6141853_6142438_-|aminoacyl-tRNA-hydrolase
MWLIVGLGNPGPKYRNTRHNVGFMVVDRLADRASAGPFKEKFKGEWCKATIAGRDVVLLKPLTFMNLSGESLQQAMAFFKTPLSEVLVIHDELDLAYRDVRVKVGGGAAGHNGLKSIVQHCGGPDFARVRIGIGRPPKGSTESWVLGEFDTMESAELPDVLQAAALAAEAVVKDGAQAAQNKFNARPKAPSEKA

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Crispr_ID: NZ_CP011125_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_22

6169716-6169956

Orphan

Consensus_repeat	Method
GAGGCACCCGTCCGAGCTGACGGATG	CRISPRCasFinder

5 spacers

The CRISPR arrays of NZ_CP011125_22

>merge|NZ_CP011125|22|6169716-6169956|CRISPRCasFinder
GATGCACCCGTCAGCGCTGACGGACGCCTCTTCGAGCCCCGAAGATCCACCCGTCAGAGCGGACGGATGGGTCATCGCAATGCGACGAGGCACCCGTCCGAGCTGACGGATGGCCCATCGAGCCGCATGGAGGCACCCGCCACCGCGGACGGGTGCACCTTCGAGAGTCGAAGAGGCACCCGTCCGAGCTGACGGATGCCTCTTCGCAACGCGACGATGCCCCCGTCAGAGCTGACGGGGG

>NZ_CP011125|22|17|6169716-6169956|CRISPRCasFinder
GATGCACCCGTCAGCGCTGACGGACG	CCTCTTCGAGCCCCGAA
GATCCACCCGTCAGAGCGGACGGATG	GGTCATCGCAATGCGAC
GAGGCACCCGTCCGAGCTGACGGATG	GCCCATCGAGCCGCATG
GAGGCACCCGCCACCGCGGACGGGTG	CACCTTCGAGAGTCGAA
GAGGCACCCGTCCGAGCTGACGGATG	CCTCTTCGCAACGCGAC
GATGCCCCCGTCAGAGCTGACGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_075098017.1\|6175945_6176422_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP011125.1\|WP_053235341.1\|6180025_6180847_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239796
NZ_CP011125.1\|WP_157069394.1\|6182669_6183482_+\|peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|379040
NZ_CP011125.1\|WP_053235342.1\|6181133_6181529_+\|DUF393-domain-containing-protein	unknown	unknown	gnl\|CDD\|367833
NZ_CP011125.1\|WP_053235330.1\|6161367_6162051_-\|outer-membrane-lipoprotein-carrier-protein-LolA	unknown	unknown	gnl\|CDD\|319983
NZ_CP011125.1\|WP_053235331.1\|6162256_6162463_+\|YdcH-family-protein	unknown	unknown	gnl\|CDD\|377305
NZ_CP011125.1\|WP_053235332.1\|6162576_6162957_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791555.1\|6167321_6168593_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NZ_CP011125.1\|WP_157069393.1\|6165847_6167182_-\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237999
NZ_CP011125.1\|WP_053235327.1\|6157684_6159520_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP011125.1\|WP_053235343.1\|6181501_6182473_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133379
NZ_CP011125.1\|WP_083457773.1\|6168699_6169683_+\|CAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|349398
NZ_CP011125.1\|WP_157069391.1\|6160252_6161446_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
NZ_CP011125.1\|WP_053235339.1\|6175214_6175883_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP011125.1\|WP_053235345.1\|6183478_6184423_+\|HupE/UreJ-family-protein	unknown	unknown	gnl\|CDD\|379373
NZ_CP011125.1\|WP_157069392.1\|6163832_6165728_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173810
NZ_CP011125.1\|WP_053235328.1\|6159533_6160244_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NZ_CP011125.1\|WP_053235337.1\|6170093_6173471_-\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NZ_CP011125.1\|WP_053238961.1\|6176530_6180025_+\|pyruvate-carboxylase	unknown	unknown	gnl\|CDD\|237263
NZ_CP011125.1\|WP_053235338.1\|6173628_6175125_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053235341.1\|6180025_6180847_-\|hypothetical-protein	gnl\|CDD\|239796	cd04268, ZnMc_MMP_like, Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.	6.44317e-13
NZ_CP011125.1\|WP_157069394.1\|6182669_6183482_+\|peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|379040	pfam13145, Rotamase_2, PPIC-type PPIASE domain.	1.29253e-08
NZ_CP011125.1\|WP_053235342.1\|6181133_6181529_+\|DUF393-domain-containing-protein	gnl\|CDD\|367833	pfam04134, DUF393, Protein of unknown function, DUF393. Members of this family have two highly conserved cysteine residues near their N-terminus. The function of these proteins is unknown.	3.14668e-20
NZ_CP011125.1\|WP_053235330.1\|6161367_6162051_-\|outer-membrane-lipoprotein-carrier-protein-LolA	gnl\|CDD\|319983	cd16325, LolA, LolA, a periplasmic chaperone. This family contains periplasmic molecular chaperone LolA which binds to outer-membrane specific lipoproteins and transports them from inner membrane to outer membrane (OM) through LolB, a lipoprotein anchored to outer membranes. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts OM-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. Studies have shown that hydrophobic surface patches large enough to accommodate acyl chains of the OM lipoproteins and the structural flexibility of LolA are important factors for its role as a periplasmic chaperone.	1.06907e-30
NZ_CP011125.1\|WP_053235331.1\|6162256_6162463_+\|YdcH-family-protein	gnl\|CDD\|377305	pfam04325, DUF465, Protein of unknown function (DUF465). Family members are found in small bacterial proteins, and also in the heavy chains of eukaryotic myosin and kinesin, C terminal of the motor domain (Myosin pfam00063, Kinesin pfam00225). Members of this family may form coiled coil structures.	0.00415339
NZ_CP011125.1\|WP_075098017.1\|6175945_6176422_+\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	2.79367e-24
NZ_CP011125.1\|WP_169791555.1\|6167321_6168593_+\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	1.9053e-05
NZ_CP011125.1\|WP_053235339.1\|6175214_6175883_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	1.52784e-11
NZ_CP011125.1\|WP_053235327.1\|6157684_6159520_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP011125.1\|WP_053235343.1\|6181501_6182473_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133379	cd01104, HTH_MlrA-CarA, Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA. Helix-turn-helix (HTH) transcription regulator MlrA (merR-like regulator A), N-terminal domain. The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. Its close homolog, CarA from Myxococcus xanthus, is involved in activation of the carotenoid biosynthesis genes by light. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA- and CarA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins.	4.16563e-19
NZ_CP011125.1\|WP_083457773.1\|6168699_6169683_+\|CAP-domain-containing-protein	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	2.1442e-14
NZ_CP011125.1\|WP_157069391.1\|6160252_6161446_+\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	3.18106e-57
NZ_CP011125.1\|WP_157069393.1\|6165847_6167182_-\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	3.72775e-24
NZ_CP011125.1\|WP_053235345.1\|6183478_6184423_+\|HupE/UreJ-family-protein	gnl\|CDD\|379373	pfam13795, HupE_UreJ_2, HupE / UreJ protein. These proteins contain many conserved histidines that may be involved in nickel binding.	4.45515e-46
NZ_CP011125.1\|WP_157069392.1\|6163832_6165728_-\|S8-family-serine-peptidase	gnl\|CDD\|173810	cd07484, Peptidases_S8_Thermitase_like, Peptidase S8 family domain in Thermitase-like proteins. Thermitase is a non-specific, trypsin-related serine protease with a very high specific activity. It contains a subtilisin like domain. The tertiary structure of thermitase is similar to that of subtilisin BPN'. It contains a Asp/His/Ser catalytic triad. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) clan include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53 the it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	1.12614e-123
NZ_CP011125.1\|WP_053235328.1\|6159533_6160244_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.27611e-43
NZ_CP011125.1\|WP_053235337.1\|6170093_6173471_-\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NZ_CP011125.1\|WP_053238961.1\|6176530_6180025_+\|pyruvate-carboxylase	gnl\|CDD\|237263	PRK12999, PRK12999, pyruvate carboxylase; Reviewed.	0

>NZ_CP011125.1|WP_083457773.1|6168699_6169683_+|CAP-domain-containing-protein
MRAALAWVIVAVLAAPGLARAQRCEDDVLAEAAAAVLMHGGDPTGAELLAAARHAGSDAPTVHALAIHDGDEGRIGPWLERLGERLRAPVVCGEARRDERWLVIAAPRAGRLVDEGNERFRIELGPGFADPMVFVEDPHGNVERVEPFEGRADVPSDLERPVRVQLVARGPDGPRPVAERRIGGDEDPARRTSADDEPLDARIEALRSQAHVSPLRPHRVLASVAQAHADAVCRVGRAAHELEPGRDPRARARERGIEARHVGEVIARGADVAGAFLALTRSPSHRSALVDRRFTDAGAGIATDDAGRACVVVVLAAWPRLVVGASR
>NZ_CP011125.1|WP_169791555.1|6167321_6168593_+|hypothetical-protein
METCTQCRASLSVGDERCPSCGAVRVPLASEPPPRDAADSDEPPPVPAGTWASTSEIESEPPPSPLRATADPDTRRIRKISREQEAGTEPEPTREPSRPVRRVRGEAAARGRARGLAIAAAAEEEQDRSDEPARPAARVVAFPTTARAADATPVQSASASSSGMRAQTAPVGPPQWLASELLRERPAAEPMAWTSRGLALFAGAGVVTAAMTLAAGEAIHLGIAGLGAAIALVAIAPLRFAMRAGAFAVLASLGLVVATMARSSPGGAEGLAAMGTTLLAAAQLLRWQNRASRFARAAMGVGVAVSASWLILDGGLDAMVVHAGGVDAWLGPAMRALLLVVLALSLLAFIDDSSDSGCRVWPWLVLGWGALDGMVASAIGPAWNAAGAATTPLFAAVAAVGWMQVWATTPGLGRESARAKGDG
>NZ_CP011125.1|WP_157069393.1|6165847_6167182_-|cyclic-nucleotide-binding-domain-containing-protein
MRTLRDLRAHADARLLAGEAHAALHAYCALVQLQPVDLDARLRVADSLLALGEVQRAAVVYTALARYATHAGYPLRALVALKVLTALEPQLEALLAPLAELYSVGSPRLGRGVRIAPGDPDQLVPETLDLAREIPLEQLAPHAERVAADTTGAAFPERLPPIPLFSELRADVFRALLPALKLRRVRPGEVVLAEGEPGQSFFVIARGEVQVTKQLAQHPEAGGGDTVLATLHEGAVFGEMALVSAAPRSATVRASTDADLLEFDRDALSALSRDVATLAVALDKFTRERLLQNLLQTSPLFRPLDRKQRMDLVRRFTAHDVVPGVQIITEGQPGRGLFVLLSGEVDVSKIDGDSKILLATLKPGDVFGEISLLHDEPASATVTAARQSTVLFLGRDIFQRLVAAFPEIREYVSQLGEERQLDTRLLLETSDGTEELDLEDLVLV
>NZ_CP011125.1|WP_157069392.1|6163832_6165728_-|S8-family-serine-peptidase
MPSTRSLPWAKVIFGIAVVALLLASVLARSGFRCPATACGAGCPPSRAALSMPHPFVADPATGALLVDLDDDASPEDREAVARELAGAIAPFAWSSGLGEMLSDEAELFRVRAPESEVSDVLARLGRNELVEGIEVERTWSLPETELGFVPSSQPPAATDGERRFTPDDPYYRFQWHLDQIGMPEAWARARGAGVVVAVIDTGVAYRDGDRFLRAPDLARTRFVEGWDFVDDDAQPDDEHGHGTHVAGTIAQSTHNALGVAGVAPEAAIMPLRVLDRNGAGGWGAIAASIRWAADHGANVINMSLGGGMRSRTVERAIEYAHEKGVVVVAAAGNASRSTVEYPARHDHVIAVGAVRFDRTLSFYSSYGRGLDVVAPGGDTRVDQNGDGMPDGVLQNTLVGRDPRRFDYVAYQGTSMAAPHVAGVAALIVGAGVTDPDAVERVLTSTAVDLGDRTRYAAGLVQANAALARASQESGAARGALAALLGLGVLVGLRRRGKLGVGLAGATMLAVVVAGGLGALPWHLVPGLGGLESLLAGGGPGAAAHIGGRWTALFAMSALVPLAAVALMLHFRKMQPLLVGLCLGTAAFLLVEALAPTTAVALLPGWLVGPWLVLNAGVALWLGRQVARQSR
>NZ_CP011125.1|WP_053235332.1|6162576_6162957_-|hypothetical-protein
MRRPLAVIFALALGACAATSSEMRRAEEAYDQARFDAARTWLVDLEDIAPSMDEPMRARYFYLRGMAEYRLGHRLEALHYLEVAHEIAGENGRGLREEQRDLLARTRAELEPVDPLSHRPPPAAAD
>NZ_CP011125.1|WP_053235331.1|6162256_6162463_+|YdcH-family-protein
MARSQSRQVDPLKELDRLERRHKKLKERVAEYEARMFLTNTEQLDLAKLKKQKLATKDAIENLRVPSS
>NZ_CP011125.1|WP_053235330.1|6161367_6162051_-|outer-membrane-lipoprotein-carrier-protein-LolA
MSTRPAPTILACFALASLVATGVIAHAQTDDASTVLAEVRARYGALRGLRARFEQRFHHRLHERDDRWRGRIALQRPGRLRIDYDVPRGRVLASDGTRIVSYEPEPAPGQYYEQAASEDAMPIALGLLMGVELPEGAVIARLVDARQTGFAGSVIELRPSEPVAQYERVWLYVDRAEERRGRVHRVMIIDHAGNTNRFDLIDQVENPRLAESTFVFRPPASARRIEP
>NZ_CP011125.1|WP_157069391.1|6160252_6161446_+|glycosyltransferase
MPATSFPTSPRDVSGLFVLGMARALASLGHEVEVLAPAPDHRDAWTDPAPGVRVRWIDYARPRALQRTFHRAGAPDNLARDPLAWLGAASFPLALAAAMRDRRWDAIASHWGVPCGLVAGAMRGSARHVAIFHSADVHVLSRAPRALARAIAERSDSLVFVSARLRDGFLALAPEARPRSHVIAMGVDAPPSVARARRERFTLLALARLVPVKGLDRAIRALPPDVELVIGGDGPERTRLEQLARTCGARVCFLGTITGDDKARWLATADALIAPSIVLPSGRTEGAPTALIEAMSAALPVVATDVGGVREIVTHEHDGLLVPPDDVGALRDAIARLRDDATLRARLSDHASHTASSRTWPALAPRFEALLAQGSMRRADAGGRNTNVDSASRGFST
>NZ_CP011125.1|WP_053235328.1|6159533_6160244_+|glycosyltransferase-family-2-protein
MLESAKVAVVVPAYNEARLIARALSGIPSFVDRVVVVDDASTDDTAREAARAGDARVEVVRHARNRGVGAAIATGTRVAFDRGADVAAVMAGDAQMDPSDLERVVAPVARGEFDYCKGDRLSHPSVRRTMPPHRWIANHVLSRLTHLATGIPVRDSQCGYAAISRSAARRVELERMWPGYGYPNDLLGRAAAAGLRVGEVTVRPIYADEESGIGIRHGLVVIPLLLARTAITRHLS
>NZ_CP011125.1|WP_053235327.1|6157684_6159520_+|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYVGDDDTAPILLDGLRRLEYRGYDSAGVAIHSSGEIKIARAVGKLRNLEKALEEKPLAGTTGIGHTRWATHGRPTEVNAHPHQSGPIALVHNGIIENHLSLRTRLVERGAKIVSDTDTEIAAHLVHEKLRENGKGLEDAVRSALREIHGAYALAVLSKDEPGRIVVAKASSPLVIGIADDASYAGSDIPALLPYTRKMIFLEDGDMAVLEKGSVRITRLDGTVVERAIKVIDWSPVMAEKAGFKHFMLKEIHEQPRAIEDTLRGRLDREHGDVHGHEIGLSDDDARSIKRVFLLACGTSHHAAMTGRYYLESIARIPTSVELASEFRGREPMIGEGDLVVAVSQSGETIDTLIAAREAKERGAKILAIANVIGSAIPRMADAAFYTHAGPEIGVASTKCFSTQLANLMMLSIWLGKRRGSLDEAKARELVEAMARLPLLMRDVITGTRQLVCNLAKRYRDARDVLFLGRGLNYPIALEAALKLKEISYVHAEGYAAGEMKHGPIALIDSAVPVFVLMPKDRWYERTHGNLQEAKAREGQVIAIATEGDESAHSLSQDVIEVPDVPEAITPFLTVLPMQLYSYYVADFKGTDVDQPRNLAKTVTVE
>NZ_CP011125.1|WP_053235337.1|6170093_6173471_-|preprotein-translocase-subunit-SecA
MLQDILKKLFGTNHERQIRKIQPRVAAINALEPEIKKLSDAQLKARTAELKQKLDNGATLDDVLFEAFATAREAGRRVLGMRHYDVQLIGGMVLHDGKIAEMKTGEGKTLVATLPCYLNALSGKGVHVVTVNDYLAKRDAEWMGRLYNWLGLSYGVVIPSQSDQAKKNAYRADITYGQNNEFGFDYLRDNMKFSIYDYAQRELNFAIVDEVDSILVDEARTPLIISGQGEVASDKYLRIARIMPRLRKDEHYVVDEKFHNATFTEEGIERAQQLLVEAGIMKSENLFDPVNLETLHILNKSLIAHTLYKRDQHYMVTADQKVVIVDEFTGRVLAGRRWSDGLHQAVEAKEGVPIQAENRTLATISFQNYFRLYKKIAGMTGTADTEAEEFHKIYKLDVTVIPTNKPIQRSDQDDLVFKTEREKFKAVYEDIVECHKAGQPVLVGTTSVEKSEALHRMLAKAEIPHNVLNAKQHEREAYVVAQAGRKGAITIATNMAGRGTDILLGGNPEMLAKYRVMDRANAEGNVELLQSRELFEAAVKEEQTRLEAECAQERKEVLAAGGLQIVGTERHESRRIDNQLRGRAGRQGDPGASRFYLSLEDDLMRIFAGERIQAMMTTLGMEEGVPIEHKWVTNAVANAQKKVEERNFDIRKNLLEYDDVMNQQRKSIYALRRQVLEGQYRTVPTEDEIKKGVKPEPIVKEIDEELRKRAKPTLERMVKVHGAKAIPPQPPARPQPPPRNATPEQLSAFNDVVRAYDVAAREWQESMRAWQETALAANVADLDEVRWQALERNIYDVFGCRVHIEKIAKKPKLVLETIEKEVGMSLSEQRERMLDLVDDIVGKLVERTCPPNKHAEDWDFDGLRKSYEETFGLKAGAVEKFHDVEDLAERLYKDGEAVLLKKEKEIGPENLLAAFRNFYLREIDRQWLDHLTNMDQLRDGIGLRGYGQRDPKKEYKKEGYDLFVGMTESIKAQVAFSMFRIQVMREEDVRRLEEQRRREVEAQQQRIMQQHIAAATTNAGPGTQPVASSSGIGAARGGARAAAAGVPAAAARGGRTIVPAQQAAAAAAPKVETVRRDKPKVGRNDPCYCGSGKKYKNCHMRTDQQSEPALDSVAPEAKSVDEAQG
>NZ_CP011125.1|WP_053235338.1|6173628_6175125_-|hypothetical-protein
MSHRARDADPPEPASSRAVVLARILVPIALGVVGYAVLISERWEVDHELQLVAPDRVRPGDPIPLRAFVFDGIDDPDGGELVAAQVDVELRDGERVLARTTLDTSRARSSEGALAPPDDATDARLDLVASARDDDGALLATVTRALTIEPDAPPAPLRGRVGLPLQQIDVGPVIAEATGVPLPPLEVRVAGGACVPEERCALWIDAGDADTITIEETPAASVGERSTRDGALVRLVVVPHGPEASVELVASRLGQPLARRTVRLPIALATPWIDAPRVVSSMPIPLEAHPPVGREVLTADLFYEGRWIATATLDPARPELPFDVGPGLYRVEVRADPFGGERAAARYVLVAPAGSDLALHDTRELLRREDVELTDREGTEPRLLLAGAEEEVRTLPSAISGLEDDRRMVAERRRRLHFVAGLALGLGIAVLAMSLLRRGLFAAAEARDVMHEAGDPEARSVRARARTTLAVIAIVGAVAVALLAGAALILARAALVTG
>NZ_CP011125.1|WP_053235339.1|6175214_6175883_+|tetratricopeptide-repeat-protein
MGYFSYYLGWILLTYLVQYPPLLVGLVVLFVLRRFVPDPWVLFRTMGRIQALRRQIDANPANVTARRDLAMVYVERLRPGRALELLDEARKRFPDDAELLYLSGLAQFKRRDYEKALEPLVKSVQMDPRVRFGEPYLVAGDALRKLGRDEEAIDAYERFVSTNSSSIEGHVKLALAFRATKDEAAAKKALDEAFATWGQIPGYKRRKELQWWLYAWICRLFV
>NZ_CP011125.1|WP_075098017.1|6175945_6176422_+|DoxX-family-protein
MDTRRLGTRRDPVALTLLRVVAGVTMAAHGWQKVEGFDGWRDTVASMGVPAADVLAALAVAGELGGGIGLALGLLTPLSALGVLAVMIVATTAVHLPNGFFAQDGGFEYPLLMATVALFFLLRGPGPYSVDAMVRGRARHRREPERGAPYREPIGRPA
>NZ_CP011125.1|WP_053238961.1|6176530_6180025_+|pyruvate-carboxylase
MATRRPRPITKLLCANRGEIAIRVFRAATELGIPTVAVYSHQDRVHLHRYKADEAYLVGKGKSAVAAYLGIEEIIDVALACGADGIHPGYGFLSENAGLSEACREVGIAFVGPSPEVLRRFGDKTAARTLAKEIGVSMVPGTDGPVSTIEQAREFCAHAGFPVIVKAAMGGGGRGMRVVRREEDLAESFSRAQSEALAAFGDGTVFIERYVDKPRHVEVQILADAAGEVIHLYERDCSVQRRHQKVVEMAPAQNLPAGVREALCRDAVALARATGYRNAGTVEFLVDREGRHYFIEVNPRIQVEHTVTEEVTGIDLVQSQIRIAGGATFADLGLSQDAVSIRGVAIQCRVTTEDPRKNFQPDTGRIEVFRAGEGMGIRLDAGSGYAGAQISPDYDSMLVKCTAHALTFEGAVHKLSRALAEFRVRGVSTNIPFLSNVLRHPDFESANVWTSWVDDTRALFDFPLRKNRGQRLLHYLGDVVVNGPGIPGMGAQPPARIEPVVPALSPEGSALKSPPPQGWRDILVHLGPAAFAKAVRKHRGLLVTDTTWRDAHQSLLATRVRTRDLLAIAPTTARLMAPLFSLECWGGATFDVSLRFLHECPWDRLERLRDAVPNIPFQMLFRGANAVGYTSYPDNVVFAFAKMAKDKGVDVFRIFDSLNYVENMKLGIDAVGNAGGVVEAAICYTGDVSDPTRKKYSLQYYVDLAGELVKLGIHVLAIKDMAGLLKPRAASMLVGALRRAYPDLPIHVHTHDTAGTGVASMLACAEADADVVDLALPAMAGLTSQPTMSAVVAALAGTTRDTSLTTDSIRKLNGYWEQTRALYAPFESGQTGYAPDLYEHEMPGGQYTNLLFQAQQNGLGDRWASIKRAYREANQLLGDIIKVTPSSKVVGDLAQFMVQNDLDAKMVEEQADTLSFPTSVVEFLEGRLGQPHGGFPEPLRTKVLRGRKPIDERPGATLPPLDLDALKKSLVEEHGDVAIRDHDVMSAAMYPQVFREYRRFRTKNGDVSVLPTRHFLAPLQKGEELLFDIERGKTLVVVLRAVGELDDEGNRRVFFELNGQPRAVSVVDRSAKAATKQRERASTSEPGSVGAPMPGSVVDVRVSVGAKITKGDPLVVLSAMKMETVVASPVSGVVKRVAVAKDDALKAGDLLVEVQVVEAAVAQA
>NZ_CP011125.1|WP_053235341.1|6180025_6180847_-|hypothetical-protein
MSRLRALAPMLLALVACDHGPAPAAIGLTCAMLDEAPTLVDLDLRFANADEAREYLEHGSSETPREHLIVATDGPSIATLPLEVRGDLTYCVSDELGASRDAVIAATERAAAMWSSVADVRFRFVTPPRCAERGVDAHLVIIPECGASRVVANAMLPWRSGRRGQELAINVCYWDHDAVVASDDALTRTLLHELGHVLGLVHAWNTADYVGACECASSTSFLALAPYDPASIMNYPDCGATWSLFDPPALSDADRAGIEELYCAPGAGPPPCP
>NZ_CP011125.1|WP_053235342.1|6181133_6181529_+|DUF393-domain-containing-protein
MREAWLVEVFFDGACPLCRREIELLRRLDRRGRVRFTDIAAPGFDAHALGRRYGEMMDRIHARTADGEWVVGVEVFRRFYEAIGLGALVRITRARPIDALLQRAYETFARNRLKWTGRCEEGTCRAATDVA
>NZ_CP011125.1|WP_053235343.1|6181501_6182473_+|MerR-family-transcriptional-regulator
MSSGNGRRLKPVSADDREGTATYPMRVVTRLTGLTADTIRVWERRYGAVRPERTQGNVRRYSSGEIRRLTLLREAVSRGHAIGEIGALPDDELEKLSSTPRQDEPSESATHRGRWWPIIESYLDAVERYDLRRADEILTRTAVLTSPRELALEVVAPLLREVGERWEHGAMSIAQEHVISGQAKSLLGTLLRAGATDAGAPRIVTAAAEAHQHELGALIAGVLASTRGVVPIHLGPDVPWSELRGAVRRAGADVVLLGFARDLERTEARRCAEELRRLADDVEVWVGAPEGHPSTSADRRVRVFHDFDEVDAELAHRFSRAQP
>NZ_CP011125.1|WP_157069394.1|6182669_6183482_+|peptidyl-prolyl-cis-trans-isomerase
MERWRRWAREPLVWFVAAGAVIFAIDRALLQDERAARAIVVDDAFVAGLRARFVERHGRAPDAREEDALVRDFVREEALSREARAAGLDEGDAIVRRRLVQKLELMLAGSVHVPEPDDEALETWMRAHEDELRVPARVTLEHVLFARDLRGARAEEDARTALDTGAIESGDPFVRGRAIGPSSEARIAAEMGAAFARAVIDMTPEQGWTGPIASTYGAHLVRVIAREEARMPALDDVRARVAAAWIEERRAALVDAEIARIVASYDVVIE
>NZ_CP011125.1|WP_053235345.1|6183478_6184423_+|HupE/UreJ-family-protein
MRVALVIAIVLIASTAHAHPLAFGALDVREDARGDVDVSFRFSGTETRVTGAEVVMPSRCVARGELVSAITGGESRVMRFACGGLGGETIAVRGMEGTGVQIAVRVERADGSIVRARLDDGTREVRLDARDTGITAYLRLGVEHIAGGIDHLLFVLGLLLVVRSRAAMIAGVTSFTIGHSITLALAALDVVTVRAAPVEACIALSIVLLAREVARPESASLVRRAPWIAAGGLGLLHGLGFAGALAEVGLPSDAIVPALLGFNVGVELGQLAFVAIVVAIGLVVRVERARLACALGMGALASFFFFERLAALGT

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Crispr_ID: NZ_CP011125_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_23

6234029-6234123

Orphan

Consensus_repeat	Method
CTCCGGCTCGTCGTCGTCGGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_23

>merge|NZ_CP011125|23|6234029-6234123|CRISPRCasFinder
CTCGGGCTCGTCGTCGTCGGGCGTGATCGCGGCGAGCTCCGGCTCGTCGTCGTCGGGCGTGATCGCGGCGAGCTCCGGCTCGCCGTCGTCCGGTG

>NZ_CP011125|23|18|6234029-6234123|CRISPRCasFinder
CTCGGGCTCGTCGTCGTCGGGCG	TGATCGCGGCGAGCTCCGGCTCGTCGTCGTCGGGCGTGATCGCGGCGAG
CTCCGGCTCGCCGTCGTCCGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053235376.1\|6222690_6223428_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235373.1\|6216083_6217307_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_157069399.1\|6245602_6246949_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235378.1\|6226867_6227278_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235379.1\|6227252_6228065_-\|DUF2520-domain-containing-protein	unknown	unknown	gnl\|CDD\|378484
NZ_CP011125.1\|WP_083457783.1\|6220237_6222616_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368175
NZ_CP011125.1\|WP_053235387.1\|6244688_6245471_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235381.1\|6228608_6229211_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235386.1\|6242369_6243680_-\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_CP011125.1\|WP_075098023.1\|6228057_6228612_-\|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|185680
NZ_CP011125.1\|WP_053235374.1\|6217577_6220232_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368175
NZ_CP011125.1\|WP_157069401.1\|6250435_6251356_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235377.1\|6223465_6226588_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380149
NZ_CP011125.1\|WP_053235385.1\|6241350_6242373_-\|FecR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377406
NZ_CP011125.1\|WP_157069396.1\|6215328_6215928_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235389.1\|6247088_6248993_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227511
NZ_CP011125.1\|WP_157069400.1\|6249043_6250297_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235384.1\|6241012_6241333_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236641
NZ_CP011125.1\|WP_053235392.1\|6251436_6252012_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235383.1\|6235848_6240756_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274350

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053235373.1\|6216083_6217307_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.00089e-81
NZ_CP011125.1\|WP_053235383.1\|6235848_6240756_-\|hypothetical-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	0.00177841
NZ_CP011125.1\|WP_053235377.1\|6223465_6226588_+\|hypothetical-protein	gnl\|CDD\|380149	NF012181, MSCRAMM_SdrD, MSCRAMM family adhesin SdrD. Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.	4.42624e-13
NZ_CP011125.1\|WP_053235385.1\|6241350_6242373_-\|FecR-domain-containing-protein	gnl\|CDD\|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	2.21167e-05
NZ_CP011125.1\|WP_053235386.1\|6242369_6243680_-\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	2.50667e-72
NZ_CP011125.1\|WP_053235379.1\|6227252_6228065_-\|DUF2520-domain-containing-protein	gnl\|CDD\|378484	pfam10728, DUF2520, Domain of unknown function (DUF2520). This presumed domain is found C-terminal to a Rossmann-like domain suggesting that these proteins are oxidoreductases.	2.75904e-27
NZ_CP011125.1\|WP_083457783.1\|6220237_6222616_+\|hypothetical-protein	gnl\|CDD\|368175	pfam04885, Stig1, Stigma-specific protein, Stig1. This family represents the Stig1 cysteine rich plant protein. The STIG1 gene is developmentally regulated and expressed specifically in the stigmatic secretory zone.	2.4599e-12
NZ_CP011125.1\|WP_053235389.1\|6247088_6248993_+\|hypothetical-protein	gnl\|CDD\|227511	COG5184, ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton].	4.38164e-31
NZ_CP011125.1\|WP_053235384.1\|6241012_6241333_-\|hypothetical-protein	gnl\|CDD\|236641	PRK10019, PRK10019, nickel/cobalt efflux transporter RcnA.	0.000425029
NZ_CP011125.1\|WP_075098023.1\|6228057_6228612_-\|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase	gnl\|CDD\|185680	cd02165, NMNAT, Nicotinamide/nicotinate mononucleotide adenylyltransferase. Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT). NMNAT represents the primary bacterial and eukaryotic adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide. It is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, and can participate in both de novo and salvage pathways of NAD synthesis.	5.84807e-58
NZ_CP011125.1\|WP_053235374.1\|6217577_6220232_+\|hypothetical-protein	gnl\|CDD\|368175	pfam04885, Stig1, Stigma-specific protein, Stig1. This family represents the Stig1 cysteine rich plant protein. The STIG1 gene is developmentally regulated and expressed specifically in the stigmatic secretory zone.	4.34842e-12

>NZ_CP011125.1|WP_053235381.1|6228608_6229211_-|hypothetical-protein
MRIGLLGPTEDDQAGFREAVSFLLADVEADQIVYLGRGEFADRAIDAWVRELGGADDAESAFLARAAHLATDGSPAQIEALLETDAAISQLARIRKIPPPPSRAIEMLDDRVVLFVHDKSILDEEDIANAHLIVYGRGAEADLRRFGKRTFFTPGPLSGGRVGVLESSDDGTSVALYDLSGMPVWREPIVSPGSKVIVAT
>NZ_CP011125.1|WP_075098023.1|6228057_6228612_-|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase
MSETIGVFGGSFDPPHCGHVLLATYALSAAPIDRLLVVPTFAHPFGKQMAPYEHRVAMCERAFGLLRGAEISRIEEELGGASYTVRTLEALHARHPGVTLRLLVGADVLGDLEKWKDFERVRALAPLFVVGRSGYAREAGMETPDLPAISSTRVREQLRAHRTIGGLVPREVARYCDEHGLYHG
>NZ_CP011125.1|WP_053235379.1|6227252_6228065_-|DUF2520-domain-containing-protein
MAERVVVIGRGRLGTRVARAVSAQLVGGRDHSLEVVRAAGVIVIAVPDPAIESVAERIAPVLDPSHVVLHCAGSRGRDVLASCAARGASTGVMHPLVAIASEESVLADRTFVIDGDERAIDAASRIARACEARVVIAPLHGPAYHAAAALVANGSTALAALGVSILERLGVPSGDAARAIGGLLASVAQNVASVGVPRALTGPIARGDAQTVARHREALAEIDRVTLAAYDAVAPSILEVATRAGLDGRAQRAIRRALGRRGLSGPRGAS
>NZ_CP011125.1|WP_053235378.1|6226867_6227278_+|hypothetical-protein
MKTTTTPTTRAPELALSPRTVYALDTVASAVLGAGMIAVAEPLTELLAWSLPPAFLVVLGATLLPWAAVNAWSARQSTQPAAAFGMHVLVDGGWVLGTLALLVLERDLLSTAGVALLAAQGVAVLGVLVMKLRAGR
>NZ_CP011125.1|WP_053235377.1|6223465_6226588_+|hypothetical-protein
MKHVRVWSAAALVTGSLAASPSGASAAPPVIAFTSPTAIEEGREVTLEVTVTDPEGAPVTWSWDTDGPDGVFGDHPNAASFTVPAAETDGPGNLRIGVRATDGTETTTVYRTITVANVAPEITSFPLTTGSVRHEYRYELRTSDPAGANDPITYALTARPPGMEVVDGVVTWTPTIDQRGRAFDVTVRAADGDGATDTQSWTIEIARNTAPSVPSLSSPIERARIAGDEPTTLTVQNATDPDGDPLVYFFRLSRESQFDPARVIGSGEVAEQEGETTSWTTSEPLDPGLWYWQAWVSDGIVETSPRFGSFIVGDTEYELNALPDAGTPDAGSDWTSLLDAGPSNDAPRGGCAVDAGATRGSSAAWLAGVLALGLVAFRRARRSAASALVMAALTALAVGCTDGEQMTGGDGGAVVGDDSDFDTISDADEGADEGVDTDEDSNPDFRDPDSDGDTIPDSAEAGDEDRATPPVDSDADGTPDYRDLDADDNGIPDGFETRGDTDLDGIADHADLDDDGDLVRDVLELMGVALPPADTDGDVLANYHDPDCDDDHILDGDEWNADTDQDGLLDFEDHDTDNDGIPDAVEAGDADIFSAPRDSDDDGTADFRDTDSDNDGLSDSLERESGSDPTRDDSDGDGVSDLIEVGAGTDPNDGSVSPRTRGDFVFVVPFEEAPAPARDTLRFRTTLQLVDVYFLFDISGSMSGELEALAGAVSTISTDLTCTSFGRACRADGDCDGGQACSVEGVCIEDPAFSSCVASAWTGAGIYEQELENLLSVQDDPARTAAALNVGTFGGTEQLFRAAWGVADPAGAPGVESGCAVPALGRLGCPAFRENAQRILVIFTDEISSGSETAAQAGAALRYANITTIGVWSGTPGAAARDSLVQLARASNSFSSTGQPLVFEGMDGAVVPRVISAINEVVEGVPLRVTITSADEPGDAGDALQFIDHVEVNVANPDCTAIRPTEDTDANGHDDAFPSLLPGTPVCWDVVVRQNDTVEPATVPLVFRARLTVHGDGSPLDSRIVYFLVPPVIPGPEVPI
>NZ_CP011125.1|WP_053235376.1|6222690_6223428_+|hypothetical-protein
MQPRSDLGRAPRAIFVLGVVLLAACGDSDGSGADSGAPLDAPMEDAFVPGALCSNELLDGHETSVDCGGPECTACGAGRGCRAASDCADGVCQRGFCLEPSCVDGVENGAEVGVDCGGECGLCPEGEPCTANSECESGRCGAGAICAAATCDDGLRNQGESDTDCGGPCERCPPEAMCTTADDCESLRCVLGRCLAPSCNDRTRNQDEAGIDCGGALCPRCGPGLTCTLDADCASGDCNAENRCE
>NZ_CP011125.1|WP_083457783.1|6220237_6222616_+|hypothetical-protein
MNENGSEAMLARTLWIGLALTLVLVGCGGDDDGTDPGVDASTPLVDAGPLECADGTTRCGTECVSTSESRRNCGACGNACAAGEACVDGECGVLCPSSQTECGGTCADLATDRSNCGECGNACGAGQVCADGECAVSCPEGQVVCGGVCADLQSSHANCGECGNACAPGAVCNAGHCEITCGGSLAACDGACVSLATSPDHCGACGNACPAVAGGTPFCSNGSCRFECSALQGDCNGIATDGCETPLATDVENCGGCGIGCELADAVAGCSAGECVLASCDAGFDDCDGAPENGCEAELATDALNCGACGTVCGVDQACVRSTCIAAGGGGAGAGDRCESAIPLTVGTNTITWEAATNDYLRERASCSTSAGLNGPDIVLSYTAPANQALTFTFHKANSASSATSYAPLLVSLVTTCGDPDSEIACLYASTLSAAMQPTDQVVVPAGTTVYVHVIDSGTASDLPPLPNPLTVDVTATQVACAPGIGGVVGNTQTDVITNIGTVTADYLAVDDEYFYVGDSSAFFRAPRAGGSHQDIEAAAGLTSSHLGAAMAIHGDDIYMVEATTSSTVGSRGRLFRISRDGGVTWRIEDYADFFPIPADDFRSAYVYGDKLYLLTEEDSTGVSTEIWSVDLGVTLDDTTRFVAAVQERVLSPSSTPGMGDCNGLTRDATYFYLACVDTTSTDTLFRVPVAGGAPEVMFASPAFDINSSVSSTLRGGDTDADGTFDVLYLVGAASSGDFTDTVQFVCEPAGPSPTLSTLANVTGMTGGLAIDPATGALVTFDDSADEFVVIQ
>NZ_CP011125.1|WP_053235374.1|6217577_6220232_+|hypothetical-protein
MNARSIVPTLALAALVLAGCGDDDSSATPDAGARDDASAPTQDSGPPGCAPGTSMCGDICADTDSSRAHCGECGNACAAGEACLEGSCAIVCPGSQSACDGVCADLDSDRRHCGECGATCDAGELCVDGACAVSCPSGQTLCGTTCVDTQSEPSHCGECGNACDAGEVCSEGTCAATCSSGLTECDDACVDTNDDPSNCGACGNECATEADGAGGACIAGSCRTLCEPGYGDCDADLTSATGNGCETAVSTDVTNCGACGNACDLANATAGCDAGGCVIATCDEGFLDCDTSPTNGCEVSLADDAANCGACGNACAAGEVCGAGACVVPAGEDCGNPIALTPGRHVLTWTAADADYITSTPACGAGYAPAGPDVVFSYTNTSAAQEWISTFFEKPEGARWHALVTTGAACGTLDGALCTSDFYSPFLGGGALLAPGQTAHLYLIDSVSGGAPLSRPLTVDFDATACDATPSMTRLIPANGGTTPIRAATFTAQFSAPAVPGGTVTITGNMGTALSYPVGTEATAPARLDEATRTILTIDPGISFPPGEQLTISWTGLNLRTCSPTTSVPAPTPTWQVTVRTPPCTPGMAGMIGDTVAIHSVGGSYAAEQYVAADSDPNGYVYVGGTAALWRFPKAGGAGTNLVGSSPITSDHLGYAMLIDGQNIFTVESDSAPIPTGHLYRVSTDGGATWSVEEYMEFSVAPNDDFRGVTISGDRIYLVTHEDSTATGPYPAQPTQIWSVPRVATTLPVEPVLELEVAEGDCTSVVRDASFYYLVCDGAGAIIRYAHDGTGRRTMPNRWHVETNATVNALHGSDTDADGVFDVLYYRAAAEQIDYVCNPATSPYVDHLVRFSTVTASAYGLGLDPVGGVLWSYDDDTYEIVSVQ
>NZ_CP011125.1|WP_053235373.1|6216083_6217307_+|serine/threonine-protein-kinase
MPVLPRRFGRYQLFDRIGKGGMAEIYLARAASELGAERLVVVKQIHEALSRDESFARMFIEEAKLCAGLRHANVVQVLELGREDGLLYMAMEYVEGFDLHQLLARCSRAKVALPAEFALFIVREVLAALDFAHRATDASGRALGIVHRDVSPSNVLMSLEGEVKLCDFGIARAAGAQEERSGDAKVVGKSAYMSPEHARGEALDARADVFAAGILLWELCAGRRLYRGSEEEMLELARRGEIPALPERGLPQPEKLQAILDRALARDRDARYATAAQMRAELDEYAHGARLFASQIRFGAFLSDHFGEEFVKERRARERAARALELGPPVRLEPIAMPAAVQGFAEIDTDRNIRRDEDTVPEARALPAPESEPMKTATTKPRRSRALVIGAITMTLVLAVLVALMSR
>NZ_CP011125.1|WP_157069396.1|6215328_6215928_-|hypothetical-protein
MSRRVLVLLVSSLLFACGGDDDSVVPEDDAGVVTVTAHARIAWRVRCGGATGCTDDAPARVVDHDDAEAAHAVECDVTAMPDGNRRFDVTIATPDGAAMRVRGATIAADGDRIIGSSCRLEIDEPDDFDLEGACSSNPPSADRPCQIQRIDITAEGAVTAEIRCADVPAAGNPGVTRDVTDDDVAAAVAELELTGCAGL
>NZ_CP011125.1|WP_053235383.1|6235848_6240756_-|hypothetical-protein
MTTTQPPITSSSRPGGGLSPDPVDARVAMLRAELEAATDRAHKAAIQYELGHVTEVELGQEAQAVREYLAAYNLDPSFAPPLVALVRIFERRRSFKNLARLYEAETKSAASPEERASSLVDRAVLAEDQLGSPDAARALYEQAIVEHPEGAALPALFLERLLLARGERDAATDAIATRAAQVADPTLKGMLLIEVARGREERGDVDGAIEAARQAATLPSARFRFLEQLERIARRHARVPEIVAALEGRAALAARAARGEAPAGSEGTAGSGAFSIKRFADEARAAGEAAALYREAARIRMLHLRSQDGTGDAQGALAALGKAILLRSGDLALHRDRMLAAELAGDLVTAADEARRLLAAGVEGRHAAPLHFRVAEEAQARGETDEARAALAAALEADPRSAVVAAMLEDLSVAGAQAGDGRLEGWIARLGARAESSEGALRARLAWQAAHLAATRTNDAERACALYATALDAAAEDTKATLAREWLGASLRLGHATGARDAAKALLEQPIDDEERSAILRDLHELERMVLEDDAAADATLDRALQTSVAAWAPDAARVLAAMRGDGALLARAHRKLAERAADADAAAAHLCAAARALVRVAASREGGLEASRTELEEAATLLADALQRVPGHRYAVALLEEVYRARGDADAVVKLLREAAEADRAGRAMETQLLLAGAAAEAAGDHALARRTYEEAAERDPSAIGPLFALRRLAELREDDALLRLALERLSEVEVGAGAPGRATLEVGEHLQLVAKEPSLAEPALRLALGVADLAAPAALDLALMGPASPASMLDGTRELVTRAEGDARLAWRRELGGVQLDLLGETAAAEAIADEILGASPDEPWALLAKLRATSSDPARAADRAAAMLALADATSDADASADLVVHGLRVAALAGQAADDAILRAVELEEARPGSFAAAALGLEALSEADDPGERADALGRWAAHASTESARAIHAARARALAAAARGAEACDALREALAGDPEDLASWEALRVAARDAERWMDVVEACDRLAAQVDGALRATLLEEAAAVLMDQTDPEDAEALVQAERRLREALEIDGGRAIAYGRLHDLLAERGDDAGLLELVQARADRTDDPEQLSPLFYELARLHRGLGRRDDALVSLDNLLMLEPEHVGGLALLVELHVQREAWPEAVQALRTLAGASDVPASQRRIARLGAADFLDKKLSQPLAAADELEAIEGLGLADRALFERIADLCERGGRVDRAVQVLAKAAAAAREPAQRAAAERRAARLWDERLGDEDQAIAAYRRALEAVPTDVEAGAALAVLLDGPSRIALSTSFERSVREVLDADPTEPEALRMLATAARWRGDKVLETAVLGALVAIDLATEDEREQLGEDTEVLRRVKPGATKLTEARLTELMVSGVSGPVMELALLATETLTEMDRLEPSSFGMGRGELLRDPATSPAAQEVLGISMLLGAPAGDVWAGGRDPQLLAVIPSYKGKPAWLLGGGVGPPLTSLRRYEIGRSAIALRLGLGPFVTRSVDATATALFAIASAAGAPLPVGEGRAGMADATRAANKAMSRRVRKAAPEAIAKIAEGGRPVLAFASALHASFARAGLVVAGDLHGVLATVLGRAPERDAVRANASALDLLRFWISPAAITTRRELGLAS
>NZ_CP011125.1|WP_053235384.1|6241012_6241333_-|hypothetical-protein
METATRVDHDHVADRDDVADHDDVADHDHDHDHDHDHVADRERVADRDAAACRRRGRGGRVNVVVVVNVVVVVVGRASWSVARRGWRVASTKPICDRFPSARKSAS
>NZ_CP011125.1|WP_053235385.1|6241350_6242373_-|FecR-domain-containing-protein
MRFFALAALLITACGGGEDERPPRSASAPQAAVERHAGEPVEVIGTPPDQPPARLARATGDVLRSRGPIEAGAPLEAGDGLVVRGEGRADVDLGDGGRVSLGPDTELRIGDGGPAQVVLLEGSLHAAVPAGPAGPRPPLRIATAHASIDLGGSGELFVRAHRTGTWVASLAGLGTVATGEVDGRRRLRVIELPPGRAIFVGARLAEPTDGPTRLDDARSAAVTIFEGAAEPEAARLTRELDDAASRLDESLLWLEAETRRGLDLTTQHREAVRAGRADEGMRLQRELVTHSQQLYALRQVATARWERLHASALATAHVPGTTPSTHAETRRDRVASLLGL
>NZ_CP011125.1|WP_053235386.1|6242369_6243680_-|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase
MNDAVAPPQLSFWPTTDVGRVRDHNEDAFLVDKKLQLFVVADGMGGHAAGEVASNLASRTVRDVIAGQREALVEFEQGHGGTTRTDLLRLMESAVQQACSAVYQEGVKDETKRGMGTTLDALLLVGNRGFIAHVGDSRVYLYRQGSVHQLTEDHSLINELLKRGRLSREQIEKLQYKNAVTRAVGVYESVEVDTIDFDVLKGDRFLICSDGLHGYFEEAELAKLFAETPEDQLSQRLVELSNERGGKDNITAIVVKVPDAEAGVDRLAREVNLKMEVLHRMPLFRFLTYQELVRVLNITHVRTFEPGAEIVGQGSDGDELFIVLTGNVQVEASGAPIASLGPGQHFGEMALIDKAPRSADVRAIEASSLLTIRRRDFFDIIRKDHAIAVKLLWSFLGVITERLRNTSRELGEAREGKRAPDLADSILRAFEHPEDS
>NZ_CP011125.1|WP_053235387.1|6244688_6245471_-|hypothetical-protein
MARSLTATDVVQLPTLSAEDAFTLVSQLLHQASRVPAPASLEELVVELASRHSALQSQLVARRAKPGVDAKSAVESDRRVDTAWSALRDWLSGWVKLGAAAPRATEIAELDAFLFGDGLGFLGLRYEAQWAAAETRLAGLRARRNEELVRALGGGPFLDVLYAAQARYGEVLGVSGDAPAPPSDAKIRESRDAMLDALREYVVGVLGTVRRSRPVTAERADELLRPLAQWETPPRASSSAPQDGDEDAEGGGTPPAPATT
>NZ_CP011125.1|WP_157069399.1|6245602_6246949_+|hypothetical-protein
MRSLVLLPALFVLAACGDDDGDTTLDAGDRRDATIATDAAGLDAGSDPDAAAPDAATPDASTSDASTLDAGGSGDAGTLPDAHTGDGGTSGGWRATTLVPWSRIIGSEPDASVLDVDLVMDGAAAHACASIRMRTGVTTYERRVLYATNEGGAFRVEVVRVTPDEQPAQCSIALFEGAPHVASSATTVDGFALQRRTATGAWEAVAVDLEPPPDDVSQVTVHALRADASSLALVISRRRDPGFPAPANYELRVRRRTASGWGAWIDGGPSASRAGMELEGGVLRGAASVPASAGLWSLDLATGERMTRAVLDGSALAGEDVRGVGGLALVGAPVLLGAVHYDCDGFSCSALVLTHAPEGETATHHVLADRRIGVWSTARCGDDATVMHVDGSMRTLHTSTAGATPVSTTLAVATESTVVDEALGVDCASGRMVLVTARYGELVAFESP
>NZ_CP011125.1|WP_053235389.1|6247088_6248993_+|hypothetical-protein
MTNLRTSIAFAVLIASAGCDTDPICTPLVYDRNERRCVCPPGSEWIMDEAICVLPDGGMLHLPDDAGSRSADDACVPQAWYRDGDGDGHGDPLTRVDACEAPDRFVAAGDDCDDECETCAPGRAEECDGTRDENCVGGVDEGCDCATGRSRACPGGTDIGECAAGVQTCIDGAWSDCDGAIGVATEACNGLDEDCDMVIDGPAASAACGSRPRATSVACSGGACVVAACTTGFDDCDDDDANGCEAELAADESNCGACGNQCGWWCDGSDCVGIATPVAGSSITCLITDRSELACAGTNDAGALGVGDTRTFSSRPVFVVSPSATTRLTGVTQVSVGTQHVCAALSDGRVACWGSNLYGQLGPGAGAQQSRPYVVPGLSTAVEVVAGQQHSCARLASGGVRCWGNNEAGRLGDGTTTQRTTVATVLRSDGTPLTGVQRLSVGTAHTCAITSARTAWCWGSNFFGQLGDGTTTTRPSAVQVTGLSNVVQLESGSAFSCALDSFDRVRCWGDNVHGQLGDGSTTRRPAPVQASISDVEEIGTGSSHACARVSGGRVLCWGRNAFYELGDGTRTTQLAPVVAQFTNVEALVVGGARTCILDTAGRLWCVGINDRGQFGDGSVPNSDGTATPVRLIEP
>NZ_CP011125.1|WP_157069400.1|6249043_6250297_-|hypothetical-protein
MVGNGRLGTLACVMALVVGCGESRTTDADAAIVIDLDGAMLDAGQDAGPPSNIGAACSDESTATDCTGGADTCIADPDYFPDGYCTLECGSDEDCGEGGICSDFFGPSFCVDACDAAGTDQCRDGQGCTLDHPMLPLPFCLGGGCEEDRECPEGLRCDPDGGDLGEGNCYDPTASIGEPCEDESACPMSALCLSEALGGWPSGACIATGCDPAASGSCGADAHCLPSAGGGGGLCVDACATAEDCRAGYTCRGTSTYPDRLTCQPACSDADCTAGRVCNEVLGTCDDPFPAGQLGAQCSRFGGGMPCTGGTCYSEGQTGYPGAYCAFEGCNVGDDTTCPDDGVCIAATEAGEPNVCFKRCAVSTDCRDGYTCRDVDGEGEGTVGACTPQCTATMQCANRDRGFTCDVASGLCVRAEG
>NZ_CP011125.1|WP_157069401.1|6250435_6251356_-|hypothetical-protein
MQHAAPFRGLAVALALVGAPGAALAQDDPCVDDTSPARRPVEVTPSVGAFNVTLDAPIAVRYSRGYFGPDGPGDDPATLLRIVRCPADVECSAGCSAADGEDVAGRVQVIGDQLFFFPDGGFEPSRAYAGRAGGIDESLDFRFCTGVTVDNGPPVLGEFLDAEPSESTAECVLPEGGRLVGLRWEQATDDGPPGSIEYMLYLTRAAGVNAPQLRDRVRNYASREITLNLRLDALEASEPVCVRVFAADGVGNVSEPSDERCFDPLTDAAFQPLCAVSAPGSARAMPWALAGFALVLGVIVARRRAR
>NZ_CP011125.1|WP_053235392.1|6251436_6252012_+|hypothetical-protein
MSSASFLDGLALAATLTGDRGRAAEAGLAPELARALEARVQEIRGADTQGRQRALGAIAVGLRPGIDARATLPARGAAILASEVPRATGAAWMARAPLPRPGFRASAGLRATMRRLAGAPIDEAADRARGAVLAQEQDERSATFVRIARATGRDVEAALGAMERGAREGGEDRGARAGRELAALWERGCRG

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Crispr_ID: NZ_CP011125_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_24

6244222-6244286

Orphan

Consensus_repeat	Method
GTCGACGGGCGCGACTCGGAACGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_24

>merge|NZ_CP011125|24|6244222-6244286|CRISPRCasFinder
GTCGACGGGCGCGACTCGGAACGGTCCGCGCGGTCGAGCGGCGCGACGGGCGCGACTCGGTCGAA

>NZ_CP011125|24|19|6244222-6244286|CRISPRCasFinder
GTCGACGGGCGCGACTCGGAACGG	TCCGCGCGGTCGAGCGG
CGCGACGGGCGCGACTCGGTCGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053235383.1\|6235848_6240756_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP011125.1\|WP_157069403.1\|6255443_6256058_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069399.1\|6245602_6246949_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069402.1\|6252571_6253510_+\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|100081
NZ_CP011125.1\|WP_053235386.1\|6242369_6243680_-\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_CP011125.1\|WP_053235379.1\|6227252_6228065_-\|DUF2520-domain-containing-protein	unknown	unknown	gnl\|CDD\|378484
NZ_CP011125.1\|WP_053235387.1\|6244688_6245471_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235384.1\|6241012_6241333_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236641
NZ_CP011125.1\|WP_053235381.1\|6228608_6229211_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_075098023.1\|6228057_6228612_-\|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|185680
NZ_CP011125.1\|WP_157069401.1\|6250435_6251356_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235393.1\|6251999_6252575_+\|type-III-secretion-system-stator-protein-SctL	unknown	unknown	gnl\|CDD\|224236
NZ_CP011125.1\|WP_053235382.1\|6229219_6235852_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NZ_CP011125.1\|WP_053235377.1\|6223465_6226588_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380149
NZ_CP011125.1\|WP_053235385.1\|6241350_6242373_-\|FecR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377406
NZ_CP011125.1\|WP_053235395.1\|6253553_6255239_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235389.1\|6247088_6248993_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227511
NZ_CP011125.1\|WP_157069400.1\|6249043_6250297_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235378.1\|6226867_6227278_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235392.1\|6251436_6252012_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053235383.1\|6235848_6240756_-\|hypothetical-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	0.00177841
NZ_CP011125.1\|WP_053235393.1\|6251999_6252575_+\|type-III-secretion-system-stator-protein-SctL	gnl\|CDD\|224236	COG1317, FliH, Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion].	1.24382e-17
NZ_CP011125.1\|WP_053235382.1\|6229219_6235852_-\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	2.4109e-23
NZ_CP011125.1\|WP_053235377.1\|6223465_6226588_+\|hypothetical-protein	gnl\|CDD\|380149	NF012181, MSCRAMM_SdrD, MSCRAMM family adhesin SdrD. Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.	4.42624e-13
NZ_CP011125.1\|WP_053235385.1\|6241350_6242373_-\|FecR-domain-containing-protein	gnl\|CDD\|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	2.21167e-05
NZ_CP011125.1\|WP_053235379.1\|6227252_6228065_-\|DUF2520-domain-containing-protein	gnl\|CDD\|378484	pfam10728, DUF2520, Domain of unknown function (DUF2520). This presumed domain is found C-terminal to a Rossmann-like domain suggesting that these proteins are oxidoreductases.	2.75904e-27
NZ_CP011125.1\|WP_053235386.1\|6242369_6243680_-\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	2.50667e-72
NZ_CP011125.1\|WP_053235389.1\|6247088_6248993_+\|hypothetical-protein	gnl\|CDD\|227511	COG5184, ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton].	4.38164e-31
NZ_CP011125.1\|WP_053235384.1\|6241012_6241333_-\|hypothetical-protein	gnl\|CDD\|236641	PRK10019, PRK10019, nickel/cobalt efflux transporter RcnA.	0.000425029
NZ_CP011125.1\|WP_075098023.1\|6228057_6228612_-\|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase	gnl\|CDD\|185680	cd02165, NMNAT, Nicotinamide/nicotinate mononucleotide adenylyltransferase. Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT). NMNAT represents the primary bacterial and eukaryotic adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide. It is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, and can participate in both de novo and salvage pathways of NAD synthesis.	5.84807e-58
NZ_CP011125.1\|WP_157069402.1\|6252571_6253510_+\|site-2-protease-family-protein	gnl\|CDD\|100081	cd06160, S2P-M50_like_2, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with additional putative N- and C-terminal transmembrane spanning regions, relative to the core protein, and no PDZ domains.	1.7616e-45

>NZ_CP011125.1|WP_053235386.1|6242369_6243680_-|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase
MNDAVAPPQLSFWPTTDVGRVRDHNEDAFLVDKKLQLFVVADGMGGHAAGEVASNLASRTVRDVIAGQREALVEFEQGHGGTTRTDLLRLMESAVQQACSAVYQEGVKDETKRGMGTTLDALLLVGNRGFIAHVGDSRVYLYRQGSVHQLTEDHSLINELLKRGRLSREQIEKLQYKNAVTRAVGVYESVEVDTIDFDVLKGDRFLICSDGLHGYFEEAELAKLFAETPEDQLSQRLVELSNERGGKDNITAIVVKVPDAEAGVDRLAREVNLKMEVLHRMPLFRFLTYQELVRVLNITHVRTFEPGAEIVGQGSDGDELFIVLTGNVQVEASGAPIASLGPGQHFGEMALIDKAPRSADVRAIEASSLLTIRRRDFFDIIRKDHAIAVKLLWSFLGVITERLRNTSRELGEAREGKRAPDLADSILRAFEHPEDS
>NZ_CP011125.1|WP_053235385.1|6241350_6242373_-|FecR-domain-containing-protein
MRFFALAALLITACGGGEDERPPRSASAPQAAVERHAGEPVEVIGTPPDQPPARLARATGDVLRSRGPIEAGAPLEAGDGLVVRGEGRADVDLGDGGRVSLGPDTELRIGDGGPAQVVLLEGSLHAAVPAGPAGPRPPLRIATAHASIDLGGSGELFVRAHRTGTWVASLAGLGTVATGEVDGRRRLRVIELPPGRAIFVGARLAEPTDGPTRLDDARSAAVTIFEGAAEPEAARLTRELDDAASRLDESLLWLEAETRRGLDLTTQHREAVRAGRADEGMRLQRELVTHSQQLYALRQVATARWERLHASALATAHVPGTTPSTHAETRRDRVASLLGL
>NZ_CP011125.1|WP_053235384.1|6241012_6241333_-|hypothetical-protein
METATRVDHDHVADRDDVADHDDVADHDHDHDHDHDHVADRERVADRDAAACRRRGRGGRVNVVVVVNVVVVVVGRASWSVARRGWRVASTKPICDRFPSARKSAS
>NZ_CP011125.1|WP_053235383.1|6235848_6240756_-|hypothetical-protein
MTTTQPPITSSSRPGGGLSPDPVDARVAMLRAELEAATDRAHKAAIQYELGHVTEVELGQEAQAVREYLAAYNLDPSFAPPLVALVRIFERRRSFKNLARLYEAETKSAASPEERASSLVDRAVLAEDQLGSPDAARALYEQAIVEHPEGAALPALFLERLLLARGERDAATDAIATRAAQVADPTLKGMLLIEVARGREERGDVDGAIEAARQAATLPSARFRFLEQLERIARRHARVPEIVAALEGRAALAARAARGEAPAGSEGTAGSGAFSIKRFADEARAAGEAAALYREAARIRMLHLRSQDGTGDAQGALAALGKAILLRSGDLALHRDRMLAAELAGDLVTAADEARRLLAAGVEGRHAAPLHFRVAEEAQARGETDEARAALAAALEADPRSAVVAAMLEDLSVAGAQAGDGRLEGWIARLGARAESSEGALRARLAWQAAHLAATRTNDAERACALYATALDAAAEDTKATLAREWLGASLRLGHATGARDAAKALLEQPIDDEERSAILRDLHELERMVLEDDAAADATLDRALQTSVAAWAPDAARVLAAMRGDGALLARAHRKLAERAADADAAAAHLCAAARALVRVAASREGGLEASRTELEEAATLLADALQRVPGHRYAVALLEEVYRARGDADAVVKLLREAAEADRAGRAMETQLLLAGAAAEAAGDHALARRTYEEAAERDPSAIGPLFALRRLAELREDDALLRLALERLSEVEVGAGAPGRATLEVGEHLQLVAKEPSLAEPALRLALGVADLAAPAALDLALMGPASPASMLDGTRELVTRAEGDARLAWRRELGGVQLDLLGETAAAEAIADEILGASPDEPWALLAKLRATSSDPARAADRAAAMLALADATSDADASADLVVHGLRVAALAGQAADDAILRAVELEEARPGSFAAAALGLEALSEADDPGERADALGRWAAHASTESARAIHAARARALAAAARGAEACDALREALAGDPEDLASWEALRVAARDAERWMDVVEACDRLAAQVDGALRATLLEEAAAVLMDQTDPEDAEALVQAERRLREALEIDGGRAIAYGRLHDLLAERGDDAGLLELVQARADRTDDPEQLSPLFYELARLHRGLGRRDDALVSLDNLLMLEPEHVGGLALLVELHVQREAWPEAVQALRTLAGASDVPASQRRIARLGAADFLDKKLSQPLAAADELEAIEGLGLADRALFERIADLCERGGRVDRAVQVLAKAAAAAREPAQRAAAERRAARLWDERLGDEDQAIAAYRRALEAVPTDVEAGAALAVLLDGPSRIALSTSFERSVREVLDADPTEPEALRMLATAARWRGDKVLETAVLGALVAIDLATEDEREQLGEDTEVLRRVKPGATKLTEARLTELMVSGVSGPVMELALLATETLTEMDRLEPSSFGMGRGELLRDPATSPAAQEVLGISMLLGAPAGDVWAGGRDPQLLAVIPSYKGKPAWLLGGGVGPPLTSLRRYEIGRSAIALRLGLGPFVTRSVDATATALFAIASAAGAPLPVGEGRAGMADATRAANKAMSRRVRKAAPEAIAKIAEGGRPVLAFASALHASFARAGLVVAGDLHGVLATVLGRAPERDAVRANASALDLLRFWISPAAITTRRELGLAS
>NZ_CP011125.1|WP_053235382.1|6229219_6235852_-|hypothetical-protein
MSGTDDKRGADIDFDWDDALADWERDLDDKSEARSGPMPQKPAGATPAKEKEPARALYRPPDPSEFKRPVPRGAPPARPEPPKPAPPPPRVHEPVLPPAEDVHVSFDDDDDDDEHTRIASIPKELIASLVTARERDEASSEQHRLSTRPPPPGMPTSDDPIAVPPAAPPPIDLDLDDMLDGLDQDTRAYPVDVPRFVSPIRGRTSAPPGPASVPPPPASEAPAPPSVGTPTARPGAPDEDPLALALPSAPPAARTPSPEGAPPTSSTPPRKSLLPSPSDLSWEEMPEPARPTREPLADADALEDVSATPSPGARAIAPPPPARSEETPAPPPPPSGSAAAAALRAAVAARNTGGAAPLRPPAPEDTTSPSSSTPPKMPPLPRPGAAAAGGKPVVPLPRPGGLPPLPRPPGARVSVPQPGAPRVPPPPGVPAPRPPVVPRPGADVPAAVAPPPEPQAVALSGEQVHATPVTAPNDRAALDVGAPSSAVVAVSSGAAERPVADDDFAFLDALEAPAPKAAPAPEPADGFGGLLPVDDDEGGEEPSVAEVSIRVSEPDLVVAPASSPAPDDDEPEIAAIAPDDGEPELAAITPDDDEPELAAITPDDDEPEARVESVTDSEPAPAAPAPAAPVPAAAAARDRGAAAARRTVRSRKPRVEVFPLVGRGADALAARRDLLLRLAEGRSGSQRARLLLAAAELDHQLGRADDAREHTLLAREADASDPVVVRAARRDALARAAYDEAAALLEAEIALPLAPPERVAALLTLAEVRLQQLGDASGAERAALDALELAPRSVAAALVLASARAASGAGGPAVDALSRAADAWDDPRARAALRVTVAREAERTGDRARAATLHASARTDDPQALDAALGVARTEAGVPQADALEALARPLPEGALRDALLRRAALALVTSTVRETRGEERTSAARRALDMLEDARALPALRTRALAASFVGDVDVELSTLEAWAGASGGTDRALAMVRLAEKHGATGDLAAADATLHAAALADASLSTIRIVREVLARRAGNRALLVEAVESAGALAAAAKLAIDPASTMRERELLGEARRADEAPLTAEVLWLDLAAGAADAAEVASALRHEVDRTPPERRTGALLALADRALEEGDAETAERTLREARDLAPGDATVLRPLGRLAAARSPRDAAALWLEEATAASGARAAFAAATAGLLLEAAEGDAIGAYRRALDAMPGYGPALWSLEPVARAAGDAITLVDVHEQSADGALTEVDAAASLVRAALLRAESDPASASALLARAREKTPHDAVLVDLVLRLGDALTPDERAQLTLSLAEGAPRELARAIELSAAASLEDAGEPGRAAEIYRALAERHPNDPLIALPLDRAELHAGETSRVAERRFAAVRDAADDALRVLALERLAELDLEERDDAASGVLSLVSILEVSPGHVPSLRTLERYYLEQDRREDLAGIEERLAMHLETPEDAAVHLRLAARLKLAGEGTPGDAADAVLVGAAPRVRMNAWLARRIAAAARAAGASELETSTTSEIASRLPTPLARTAGTMRVADLRAAAGDFAGAASVLATAVEASPDHPFAAERLARLREGAGDARGAAEALAIAARAAHVPGRAASLWYRAGVLWQDTIGDEELALEALTEASKVDVGHLDVFDRLRNLLELREDHAALSELVARRTAAGGGDPALLVELHALQAKLKEKLGDREGAREALRAVLALSPEMLDALRRLAELCLEDEDYRNAAEALIRIARIRKDREELRWVFFTLGEIYDRHIPDAKRAEAAYRRVLKLAPDDVTAMERLAALFRRDNQLQAAAEQLGELSRVEPDPDRARGHQLALAEVLEQMGDPRRAEQVLETARRAAPTELGALKALADFYTRQRAMPAHAMHLNRAVADFRHALGNDLSDAAAWLGLVEVLGWRGRGDAARVAAGAAFALGVTDLEISRLVDAQGGVPGVGAAAADAALDDLLAPQGLPAALRAVLRSAGPVLEKVLPFDPRAYRAEKLGARDGAIRAAAVDVAKWFGIPDVEIWITPGAPRVCVPVSSGPPVALMIGRDLLAVDDRERLFVLARALKIASLGLSVAVRSQPQELVLAMAGLVHNFDPHYAPGGIDPAALGDWSKRVARQLPRRLADELGPVVFEMAGAPDYEPTRLAMAASELGDRVALLAGGSIPAGLSALLRLSGENGLAESTSTRVAQLRRFPEVLSLASFAVSDVHFDARQRAGADKL
>NZ_CP011125.1|WP_053235381.1|6228608_6229211_-|hypothetical-protein
MRIGLLGPTEDDQAGFREAVSFLLADVEADQIVYLGRGEFADRAIDAWVRELGGADDAESAFLARAAHLATDGSPAQIEALLETDAAISQLARIRKIPPPPSRAIEMLDDRVVLFVHDKSILDEEDIANAHLIVYGRGAEADLRRFGKRTFFTPGPLSGGRVGVLESSDDGTSVALYDLSGMPVWREPIVSPGSKVIVAT
>NZ_CP011125.1|WP_075098023.1|6228057_6228612_-|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase
MSETIGVFGGSFDPPHCGHVLLATYALSAAPIDRLLVVPTFAHPFGKQMAPYEHRVAMCERAFGLLRGAEISRIEEELGGASYTVRTLEALHARHPGVTLRLLVGADVLGDLEKWKDFERVRALAPLFVVGRSGYAREAGMETPDLPAISSTRVREQLRAHRTIGGLVPREVARYCDEHGLYHG
>NZ_CP011125.1|WP_053235379.1|6227252_6228065_-|DUF2520-domain-containing-protein
MAERVVVIGRGRLGTRVARAVSAQLVGGRDHSLEVVRAAGVIVIAVPDPAIESVAERIAPVLDPSHVVLHCAGSRGRDVLASCAARGASTGVMHPLVAIASEESVLADRTFVIDGDERAIDAASRIARACEARVVIAPLHGPAYHAAAALVANGSTALAALGVSILERLGVPSGDAARAIGGLLASVAQNVASVGVPRALTGPIARGDAQTVARHREALAEIDRVTLAAYDAVAPSILEVATRAGLDGRAQRAIRRALGRRGLSGPRGAS
>NZ_CP011125.1|WP_053235378.1|6226867_6227278_+|hypothetical-protein
MKTTTTPTTRAPELALSPRTVYALDTVASAVLGAGMIAVAEPLTELLAWSLPPAFLVVLGATLLPWAAVNAWSARQSTQPAAAFGMHVLVDGGWVLGTLALLVLERDLLSTAGVALLAAQGVAVLGVLVMKLRAGR
>NZ_CP011125.1|WP_053235377.1|6223465_6226588_+|hypothetical-protein
MKHVRVWSAAALVTGSLAASPSGASAAPPVIAFTSPTAIEEGREVTLEVTVTDPEGAPVTWSWDTDGPDGVFGDHPNAASFTVPAAETDGPGNLRIGVRATDGTETTTVYRTITVANVAPEITSFPLTTGSVRHEYRYELRTSDPAGANDPITYALTARPPGMEVVDGVVTWTPTIDQRGRAFDVTVRAADGDGATDTQSWTIEIARNTAPSVPSLSSPIERARIAGDEPTTLTVQNATDPDGDPLVYFFRLSRESQFDPARVIGSGEVAEQEGETTSWTTSEPLDPGLWYWQAWVSDGIVETSPRFGSFIVGDTEYELNALPDAGTPDAGSDWTSLLDAGPSNDAPRGGCAVDAGATRGSSAAWLAGVLALGLVAFRRARRSAASALVMAALTALAVGCTDGEQMTGGDGGAVVGDDSDFDTISDADEGADEGVDTDEDSNPDFRDPDSDGDTIPDSAEAGDEDRATPPVDSDADGTPDYRDLDADDNGIPDGFETRGDTDLDGIADHADLDDDGDLVRDVLELMGVALPPADTDGDVLANYHDPDCDDDHILDGDEWNADTDQDGLLDFEDHDTDNDGIPDAVEAGDADIFSAPRDSDDDGTADFRDTDSDNDGLSDSLERESGSDPTRDDSDGDGVSDLIEVGAGTDPNDGSVSPRTRGDFVFVVPFEEAPAPARDTLRFRTTLQLVDVYFLFDISGSMSGELEALAGAVSTISTDLTCTSFGRACRADGDCDGGQACSVEGVCIEDPAFSSCVASAWTGAGIYEQELENLLSVQDDPARTAAALNVGTFGGTEQLFRAAWGVADPAGAPGVESGCAVPALGRLGCPAFRENAQRILVIFTDEISSGSETAAQAGAALRYANITTIGVWSGTPGAAARDSLVQLARASNSFSSTGQPLVFEGMDGAVVPRVISAINEVVEGVPLRVTITSADEPGDAGDALQFIDHVEVNVANPDCTAIRPTEDTDANGHDDAFPSLLPGTPVCWDVVVRQNDTVEPATVPLVFRARLTVHGDGSPLDSRIVYFLVPPVIPGPEVPI
>NZ_CP011125.1|WP_053235387.1|6244688_6245471_-|hypothetical-protein
MARSLTATDVVQLPTLSAEDAFTLVSQLLHQASRVPAPASLEELVVELASRHSALQSQLVARRAKPGVDAKSAVESDRRVDTAWSALRDWLSGWVKLGAAAPRATEIAELDAFLFGDGLGFLGLRYEAQWAAAETRLAGLRARRNEELVRALGGGPFLDVLYAAQARYGEVLGVSGDAPAPPSDAKIRESRDAMLDALREYVVGVLGTVRRSRPVTAERADELLRPLAQWETPPRASSSAPQDGDEDAEGGGTPPAPATT
>NZ_CP011125.1|WP_157069399.1|6245602_6246949_+|hypothetical-protein
MRSLVLLPALFVLAACGDDDGDTTLDAGDRRDATIATDAAGLDAGSDPDAAAPDAATPDASTSDASTLDAGGSGDAGTLPDAHTGDGGTSGGWRATTLVPWSRIIGSEPDASVLDVDLVMDGAAAHACASIRMRTGVTTYERRVLYATNEGGAFRVEVVRVTPDEQPAQCSIALFEGAPHVASSATTVDGFALQRRTATGAWEAVAVDLEPPPDDVSQVTVHALRADASSLALVISRRRDPGFPAPANYELRVRRRTASGWGAWIDGGPSASRAGMELEGGVLRGAASVPASAGLWSLDLATGERMTRAVLDGSALAGEDVRGVGGLALVGAPVLLGAVHYDCDGFSCSALVLTHAPEGETATHHVLADRRIGVWSTARCGDDATVMHVDGSMRTLHTSTAGATPVSTTLAVATESTVVDEALGVDCASGRMVLVTARYGELVAFESP
>NZ_CP011125.1|WP_053235389.1|6247088_6248993_+|hypothetical-protein
MTNLRTSIAFAVLIASAGCDTDPICTPLVYDRNERRCVCPPGSEWIMDEAICVLPDGGMLHLPDDAGSRSADDACVPQAWYRDGDGDGHGDPLTRVDACEAPDRFVAAGDDCDDECETCAPGRAEECDGTRDENCVGGVDEGCDCATGRSRACPGGTDIGECAAGVQTCIDGAWSDCDGAIGVATEACNGLDEDCDMVIDGPAASAACGSRPRATSVACSGGACVVAACTTGFDDCDDDDANGCEAELAADESNCGACGNQCGWWCDGSDCVGIATPVAGSSITCLITDRSELACAGTNDAGALGVGDTRTFSSRPVFVVSPSATTRLTGVTQVSVGTQHVCAALSDGRVACWGSNLYGQLGPGAGAQQSRPYVVPGLSTAVEVVAGQQHSCARLASGGVRCWGNNEAGRLGDGTTTQRTTVATVLRSDGTPLTGVQRLSVGTAHTCAITSARTAWCWGSNFFGQLGDGTTTTRPSAVQVTGLSNVVQLESGSAFSCALDSFDRVRCWGDNVHGQLGDGSTTRRPAPVQASISDVEEIGTGSSHACARVSGGRVLCWGRNAFYELGDGTRTTQLAPVVAQFTNVEALVVGGARTCILDTAGRLWCVGINDRGQFGDGSVPNSDGTATPVRLIEP
>NZ_CP011125.1|WP_157069400.1|6249043_6250297_-|hypothetical-protein
MVGNGRLGTLACVMALVVGCGESRTTDADAAIVIDLDGAMLDAGQDAGPPSNIGAACSDESTATDCTGGADTCIADPDYFPDGYCTLECGSDEDCGEGGICSDFFGPSFCVDACDAAGTDQCRDGQGCTLDHPMLPLPFCLGGGCEEDRECPEGLRCDPDGGDLGEGNCYDPTASIGEPCEDESACPMSALCLSEALGGWPSGACIATGCDPAASGSCGADAHCLPSAGGGGGLCVDACATAEDCRAGYTCRGTSTYPDRLTCQPACSDADCTAGRVCNEVLGTCDDPFPAGQLGAQCSRFGGGMPCTGGTCYSEGQTGYPGAYCAFEGCNVGDDTTCPDDGVCIAATEAGEPNVCFKRCAVSTDCRDGYTCRDVDGEGEGTVGACTPQCTATMQCANRDRGFTCDVASGLCVRAEG
>NZ_CP011125.1|WP_157069401.1|6250435_6251356_-|hypothetical-protein
MQHAAPFRGLAVALALVGAPGAALAQDDPCVDDTSPARRPVEVTPSVGAFNVTLDAPIAVRYSRGYFGPDGPGDDPATLLRIVRCPADVECSAGCSAADGEDVAGRVQVIGDQLFFFPDGGFEPSRAYAGRAGGIDESLDFRFCTGVTVDNGPPVLGEFLDAEPSESTAECVLPEGGRLVGLRWEQATDDGPPGSIEYMLYLTRAAGVNAPQLRDRVRNYASREITLNLRLDALEASEPVCVRVFAADGVGNVSEPSDERCFDPLTDAAFQPLCAVSAPGSARAMPWALAGFALVLGVIVARRRAR
>NZ_CP011125.1|WP_053235392.1|6251436_6252012_+|hypothetical-protein
MSSASFLDGLALAATLTGDRGRAAEAGLAPELARALEARVQEIRGADTQGRQRALGAIAVGLRPGIDARATLPARGAAILASEVPRATGAAWMARAPLPRPGFRASAGLRATMRRLAGAPIDEAADRARGAVLAQEQDERSATFVRIARATGRDVEAALGAMERGAREGGEDRGARAGRELAALWERGCRG
>NZ_CP011125.1|WP_053235393.1|6251999_6252575_+|type-III-secretion-system-stator-protein-SctL
MSRVIRGPGAPPRVVPAEVVDARAEAERIVEAARREAEALLEGARAECERLRAEARAEGAASGLAQAAALLVEARRARDGALVGIERDAQTLALAAAERIVGEAITIEPARVVAIVRDVIARARRARAIELRVHPEDARALEGAIEPSVRVIEDASITRGGCVMRSELGTVDARVEVRIDAMARMLGCERP
>NZ_CP011125.1|WP_157069402.1|6252571_6253510_+|site-2-protease-family-protein
MSEIARTWWAEWRTPLALIVLTFVSTLWAGALMGGSDPWERPLELIAGWDFALPLMAILLAHELGHYVVGRMHRVDISPPFFVPMPPPFMLGTMGAVIRMRGEIRDRNALLDVGAAGPLAGMVVALPVLIYGIATSPVQPLPESGEMLIEGRSLLYVALLYALKGPIPEGHDIMLSSTAFAGWAGLLVTMMNLLPFGQLDGGHIAYALLGKTQDRIARAVLAVLPVVAIATGLFYAWPLYASGERGDPLMGSALAGVSWLVWFAVLGLMSWLSGIDHPPFEPGALTPGRRVVAIGCLVLFVLLFMPSWMRAG
>NZ_CP011125.1|WP_053235395.1|6253553_6255239_+|hypothetical-protein
MVRPLARAGVSLALILGVLVCPRAARAWTDATVRSVSAHVTIARDASAEVELVAQVRVDGGWLQAFELDGLDPDLELVPGRASFRDAEGVLLEPRVDVEGEGRVVFGFRRRGAPRRGDYVATIVYRTSLAHRATEVREDGTVLVRWVLPGWRYGLDDVAITLDAPEGAAPVRDEDDPAVEVTHAPTATGTRVVFHRVHLPRTREWVVTLALPAGRMDTSLHVPSTTPRRARPAPPMDAPSTPIGVPLLALALAVIAVAKSLVVARAERAARVPSSALVPLGLGARVVIVVVLASAAAMLHEHVELALGLLGGVALCAIHRRAQEPRAPRLGSFRATTPEDHARARRALRTSRLDVLDPTTVPGATLLGVVIAAPLIAWSRGVLPVPLPIAMVAAALATTVLLGGTRRSRPAAAHVELAHLLALAAQLRADLEDDRRWAMRPVLHTDVRGEAQDARLRIVLAAMPKGLLRLDVVRAARADRGGWSSEPVLLVVTREGSPADRALDERFPDARIASAPRRIARQLAIEPDLARTLAPVLEALAACPVETAPAPRSVGTLAATA
>NZ_CP011125.1|WP_157069403.1|6255443_6256058_-|hypothetical-protein
MQSRPSCDEQLIRLAIRSMAENGFAEAMREAILSLPQDLKAMLRVMEDPDLDDQGRVLASGALLHVLSASNAIPGVKGTLALVDDVLVLRLALERIAQTSPEVVTHHREDEPEIFEPWTVQLDAARAYLGDRGVAVLQKAVDGLPKITFQGHSARECARDQDAATWLYDSVHEAIIQQFEIAPDEVARAVKNAHEILAKVSQRA

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Crispr_ID: NZ_CP011125_25

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_25

6255307-6255443

Orphan

Consensus_repeat	Method
CGCAGCTCGAGGGGTCGAGAGGGGAGGCGCGCAGCCTCCCCCGGGCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_25

>merge|NZ_CP011125|25|6255307-6255443|CRISPRCasFinder
CGCAGCTCGAGGGGTCGAGAGGGGAGGCGCGCAGCCTCCCCCGGGCAACTACGCCCGCTGCGAGCACCGCAAGCGGGTGGGGACCCGCGCGCAGCTCGAGGGGTCGAGAGGGGAGGCGCGCAGCCTCCCCCGGGCAA

>NZ_CP011125|25|20|6255307-6255443|CRISPRCasFinder
CGCAGCTCGAGGGGTCGAGAGGGGAGGCGCGCAGCCTCCCCCGGGCAA	CTACGCCCGCTGCGAGCACCGCAAGCGGGTGGGGACCCGCG
CGCAGCTCGAGGGGTCGAGAGGGGAGGCGCGCAGCCTCCCCCGGGCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053235405.1\|6267534_6268722_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|366438
NZ_CP011125.1\|WP_157069399.1\|6245602_6246949_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069402.1\|6252571_6253510_+\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|100081
NZ_CP011125.1\|WP_053235386.1\|6242369_6243680_-\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_CP011125.1\|WP_157069404.1\|6256121_6258152_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_CP011125.1\|WP_053235387.1\|6244688_6245471_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791557.1\|6260409_6261780_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235402.1\|6265342_6266281_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380271
NZ_CP011125.1\|WP_053235400.1\|6261768_6263391_-\|alanine:cation-symporter-family-protein	unknown	unknown	gnl\|CDD\|273291
NZ_CP011125.1\|WP_053235393.1\|6251999_6252575_+\|type-III-secretion-system-stator-protein-SctL	unknown	unknown	gnl\|CDD\|224236
NZ_CP011125.1\|WP_053235398.1\|6258435_6260253_-\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238017
NZ_CP011125.1\|WP_157069401.1\|6250435_6251356_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069400.1\|6249043_6250297_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235401.1\|6263839_6265315_-\|DNA-polymerase-Y-family-protein	unknown	unknown	gnl\|CDD\|176458
NZ_CP011125.1\|WP_157069408.1\|6266994_6267534_+\|NAD(P)H-dependent-oxidoreductase-subunit-E	unknown	unknown	gnl\|CDD\|239278
NZ_CP011125.1\|WP_053235395.1\|6253553_6255239_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053235389.1\|6247088_6248993_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227511
NZ_CP011125.1\|WP_053235406.1\|6268739_6270281_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271210
NZ_CP011125.1\|WP_053235392.1\|6251436_6252012_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069407.1\|6266459_6267041_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053235405.1\|6267534_6268722_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|366438	pfam01053, Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme. This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.	5.6402e-166
NZ_CP011125.1\|WP_157069404.1\|6256121_6258152_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	1.28897e-36
NZ_CP011125.1\|WP_157069402.1\|6252571_6253510_+\|site-2-protease-family-protein	gnl\|CDD\|100081	cd06160, S2P-M50_like_2, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with additional putative N- and C-terminal transmembrane spanning regions, relative to the core protein, and no PDZ domains.	1.7616e-45
NZ_CP011125.1\|WP_053235386.1\|6242369_6243680_-\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	2.50667e-72
NZ_CP011125.1\|WP_053235398.1\|6258435_6260253_-\|FHA-domain-containing-protein	gnl\|CDD\|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	2.35871e-18
NZ_CP011125.1\|WP_053235406.1\|6268739_6270281_-\|hypothetical-protein	gnl\|CDD\|271210	cd14251, PL-6, Polysaccharide Lyase Family 6. Polysaccharide Lyase Family 6 is a family of beta-helical polysaccharide lyases. Members include alginate lyase (EC 4.2.2.3) and chondroitinase B (EC 4.2.2.19). Chondroitinase B is an enzyme that only cleaves the beta-(1,4)-linkage of dermatan sulfate (DS), leading to 4,5-unsaturated dermatan sulfate disaccharides as the product. DS is a highly sulfated, unbranched polysaccharide belonging to a family of glycosaminoglycans (GAGs) composed of alternating hexosamine (gluco- or galactosamine) and uronic acid (D-glucuronic or L-iduronic acid) moieties. DS contains alternating 1,4-beta-D-galactosamine (GalNac) and 1,3-alpha-L-iduronic acid units. The related chondroitin sulfate (CS) contains alternating GalNac and 1,3-beta-D-glucuronic acid units. Alginate lyases (known as either mannuronate (EC 4.2.2.3) or guluronate lyases (EC 4.2.2.11) catalyze the degradation of alginate, a copolymer of alpha-L-guluronate and its C5 epimer beta-D-mannuronate.	8.77209e-146
NZ_CP011125.1\|WP_053235402.1\|6265342_6266281_-\|hypothetical-protein	gnl\|CDD\|380271	NF033429, ImuA_translesion, translesion DNA synthesis-associated protein ImuA. A three-gene cassette encoding ImuA, ImuB, and ImuC (""inducible mutagenesis"") is induced by DNA damage, is capable of DNA synthesis across DNA damage lesions, and consequently is associated with mutagenesis. This family, ImuA (previously misnamed SulA in Pseudomonas putida) shows some homology to SulA itself and to RecA. ImuB resembles Y-family polymerases but may be catalytically inactive. ImuC is a C-family polymerase, and catalytically active.	2.91691e-07
NZ_CP011125.1\|WP_053235400.1\|6261768_6263391_-\|alanine:cation-symporter-family-protein	gnl\|CDD\|273291	TIGR00835, carrier_protein, amino acid carrier protein. The Alanine or Glycine: Cation Symporter (AGCS) Family (TC 2.A.25) Members of the AGCS family transport alanine and/or glycine in symport with Na+ and or H+.	2.38563e-15
NZ_CP011125.1\|WP_053235393.1\|6251999_6252575_+\|type-III-secretion-system-stator-protein-SctL	gnl\|CDD\|224236	COG1317, FliH, Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion].	1.24382e-17
NZ_CP011125.1\|WP_157069408.1\|6266994_6267534_+\|NAD(P)H-dependent-oxidoreductase-subunit-E	gnl\|CDD\|239278	cd02980, TRX_Fd_family, Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:ubiquinone oxidoreductase (NuoE). TRX-like Fds are soluble low-potential electron carriers containing a single [2Fe-2S] cluster. The exact role of TRX-like Fd is still unclear. It has been suggested that it may be involved in nitrogen fixation. Its homologous domains in large redox enzymes (such as Nuo and hydrogenases) function as electron carriers.	5.54141e-13
NZ_CP011125.1\|WP_053235389.1\|6247088_6248993_+\|hypothetical-protein	gnl\|CDD\|227511	COG5184, ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton].	4.38164e-31
NZ_CP011125.1\|WP_053235401.1\|6263839_6265315_-\|DNA-polymerase-Y-family-protein	gnl\|CDD\|176458	cd03468, PolY_like, DNA Polymerase Y-family. Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.	3.07797e-28

>NZ_CP011125.1|WP_053235395.1|6253553_6255239_+|hypothetical-protein
MVRPLARAGVSLALILGVLVCPRAARAWTDATVRSVSAHVTIARDASAEVELVAQVRVDGGWLQAFELDGLDPDLELVPGRASFRDAEGVLLEPRVDVEGEGRVVFGFRRRGAPRRGDYVATIVYRTSLAHRATEVREDGTVLVRWVLPGWRYGLDDVAITLDAPEGAAPVRDEDDPAVEVTHAPTATGTRVVFHRVHLPRTREWVVTLALPAGRMDTSLHVPSTTPRRARPAPPMDAPSTPIGVPLLALALAVIAVAKSLVVARAERAARVPSSALVPLGLGARVVIVVVLASAAAMLHEHVELALGLLGGVALCAIHRRAQEPRAPRLGSFRATTPEDHARARRALRTSRLDVLDPTTVPGATLLGVVIAAPLIAWSRGVLPVPLPIAMVAAALATTVLLGGTRRSRPAAAHVELAHLLALAAQLRADLEDDRRWAMRPVLHTDVRGEAQDARLRIVLAAMPKGLLRLDVVRAARADRGGWSSEPVLLVVTREGSPADRALDERFPDARIASAPRRIARQLAIEPDLARTLAPVLEALAACPVETAPAPRSVGTLAATA
>NZ_CP011125.1|WP_157069402.1|6252571_6253510_+|site-2-protease-family-protein
MSEIARTWWAEWRTPLALIVLTFVSTLWAGALMGGSDPWERPLELIAGWDFALPLMAILLAHELGHYVVGRMHRVDISPPFFVPMPPPFMLGTMGAVIRMRGEIRDRNALLDVGAAGPLAGMVVALPVLIYGIATSPVQPLPESGEMLIEGRSLLYVALLYALKGPIPEGHDIMLSSTAFAGWAGLLVTMMNLLPFGQLDGGHIAYALLGKTQDRIARAVLAVLPVVAIATGLFYAWPLYASGERGDPLMGSALAGVSWLVWFAVLGLMSWLSGIDHPPFEPGALTPGRRVVAIGCLVLFVLLFMPSWMRAG
>NZ_CP011125.1|WP_053235393.1|6251999_6252575_+|type-III-secretion-system-stator-protein-SctL
MSRVIRGPGAPPRVVPAEVVDARAEAERIVEAARREAEALLEGARAECERLRAEARAEGAASGLAQAAALLVEARRARDGALVGIERDAQTLALAAAERIVGEAITIEPARVVAIVRDVIARARRARAIELRVHPEDARALEGAIEPSVRVIEDASITRGGCVMRSELGTVDARVEVRIDAMARMLGCERP
>NZ_CP011125.1|WP_053235392.1|6251436_6252012_+|hypothetical-protein
MSSASFLDGLALAATLTGDRGRAAEAGLAPELARALEARVQEIRGADTQGRQRALGAIAVGLRPGIDARATLPARGAAILASEVPRATGAAWMARAPLPRPGFRASAGLRATMRRLAGAPIDEAADRARGAVLAQEQDERSATFVRIARATGRDVEAALGAMERGAREGGEDRGARAGRELAALWERGCRG
>NZ_CP011125.1|WP_157069401.1|6250435_6251356_-|hypothetical-protein
MQHAAPFRGLAVALALVGAPGAALAQDDPCVDDTSPARRPVEVTPSVGAFNVTLDAPIAVRYSRGYFGPDGPGDDPATLLRIVRCPADVECSAGCSAADGEDVAGRVQVIGDQLFFFPDGGFEPSRAYAGRAGGIDESLDFRFCTGVTVDNGPPVLGEFLDAEPSESTAECVLPEGGRLVGLRWEQATDDGPPGSIEYMLYLTRAAGVNAPQLRDRVRNYASREITLNLRLDALEASEPVCVRVFAADGVGNVSEPSDERCFDPLTDAAFQPLCAVSAPGSARAMPWALAGFALVLGVIVARRRAR
>NZ_CP011125.1|WP_157069400.1|6249043_6250297_-|hypothetical-protein
MVGNGRLGTLACVMALVVGCGESRTTDADAAIVIDLDGAMLDAGQDAGPPSNIGAACSDESTATDCTGGADTCIADPDYFPDGYCTLECGSDEDCGEGGICSDFFGPSFCVDACDAAGTDQCRDGQGCTLDHPMLPLPFCLGGGCEEDRECPEGLRCDPDGGDLGEGNCYDPTASIGEPCEDESACPMSALCLSEALGGWPSGACIATGCDPAASGSCGADAHCLPSAGGGGGLCVDACATAEDCRAGYTCRGTSTYPDRLTCQPACSDADCTAGRVCNEVLGTCDDPFPAGQLGAQCSRFGGGMPCTGGTCYSEGQTGYPGAYCAFEGCNVGDDTTCPDDGVCIAATEAGEPNVCFKRCAVSTDCRDGYTCRDVDGEGEGTVGACTPQCTATMQCANRDRGFTCDVASGLCVRAEG
>NZ_CP011125.1|WP_053235389.1|6247088_6248993_+|hypothetical-protein
MTNLRTSIAFAVLIASAGCDTDPICTPLVYDRNERRCVCPPGSEWIMDEAICVLPDGGMLHLPDDAGSRSADDACVPQAWYRDGDGDGHGDPLTRVDACEAPDRFVAAGDDCDDECETCAPGRAEECDGTRDENCVGGVDEGCDCATGRSRACPGGTDIGECAAGVQTCIDGAWSDCDGAIGVATEACNGLDEDCDMVIDGPAASAACGSRPRATSVACSGGACVVAACTTGFDDCDDDDANGCEAELAADESNCGACGNQCGWWCDGSDCVGIATPVAGSSITCLITDRSELACAGTNDAGALGVGDTRTFSSRPVFVVSPSATTRLTGVTQVSVGTQHVCAALSDGRVACWGSNLYGQLGPGAGAQQSRPYVVPGLSTAVEVVAGQQHSCARLASGGVRCWGNNEAGRLGDGTTTQRTTVATVLRSDGTPLTGVQRLSVGTAHTCAITSARTAWCWGSNFFGQLGDGTTTTRPSAVQVTGLSNVVQLESGSAFSCALDSFDRVRCWGDNVHGQLGDGSTTRRPAPVQASISDVEEIGTGSSHACARVSGGRVLCWGRNAFYELGDGTRTTQLAPVVAQFTNVEALVVGGARTCILDTAGRLWCVGINDRGQFGDGSVPNSDGTATPVRLIEP
>NZ_CP011125.1|WP_157069399.1|6245602_6246949_+|hypothetical-protein
MRSLVLLPALFVLAACGDDDGDTTLDAGDRRDATIATDAAGLDAGSDPDAAAPDAATPDASTSDASTLDAGGSGDAGTLPDAHTGDGGTSGGWRATTLVPWSRIIGSEPDASVLDVDLVMDGAAAHACASIRMRTGVTTYERRVLYATNEGGAFRVEVVRVTPDEQPAQCSIALFEGAPHVASSATTVDGFALQRRTATGAWEAVAVDLEPPPDDVSQVTVHALRADASSLALVISRRRDPGFPAPANYELRVRRRTASGWGAWIDGGPSASRAGMELEGGVLRGAASVPASAGLWSLDLATGERMTRAVLDGSALAGEDVRGVGGLALVGAPVLLGAVHYDCDGFSCSALVLTHAPEGETATHHVLADRRIGVWSTARCGDDATVMHVDGSMRTLHTSTAGATPVSTTLAVATESTVVDEALGVDCASGRMVLVTARYGELVAFESP
>NZ_CP011125.1|WP_053235387.1|6244688_6245471_-|hypothetical-protein
MARSLTATDVVQLPTLSAEDAFTLVSQLLHQASRVPAPASLEELVVELASRHSALQSQLVARRAKPGVDAKSAVESDRRVDTAWSALRDWLSGWVKLGAAAPRATEIAELDAFLFGDGLGFLGLRYEAQWAAAETRLAGLRARRNEELVRALGGGPFLDVLYAAQARYGEVLGVSGDAPAPPSDAKIRESRDAMLDALREYVVGVLGTVRRSRPVTAERADELLRPLAQWETPPRASSSAPQDGDEDAEGGGTPPAPATT
>NZ_CP011125.1|WP_053235386.1|6242369_6243680_-|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase
MNDAVAPPQLSFWPTTDVGRVRDHNEDAFLVDKKLQLFVVADGMGGHAAGEVASNLASRTVRDVIAGQREALVEFEQGHGGTTRTDLLRLMESAVQQACSAVYQEGVKDETKRGMGTTLDALLLVGNRGFIAHVGDSRVYLYRQGSVHQLTEDHSLINELLKRGRLSREQIEKLQYKNAVTRAVGVYESVEVDTIDFDVLKGDRFLICSDGLHGYFEEAELAKLFAETPEDQLSQRLVELSNERGGKDNITAIVVKVPDAEAGVDRLAREVNLKMEVLHRMPLFRFLTYQELVRVLNITHVRTFEPGAEIVGQGSDGDELFIVLTGNVQVEASGAPIASLGPGQHFGEMALIDKAPRSADVRAIEASSLLTIRRRDFFDIIRKDHAIAVKLLWSFLGVITERLRNTSRELGEAREGKRAPDLADSILRAFEHPEDS
>NZ_CP011125.1|WP_157069404.1|6256121_6258152_-|OmpA-family-protein
MRRIARILGFATLIALAHAAVLAPSGTAEAQGAGGRLTSGGMDLHLFRPAVDSKGLLYTNGTDILGHLAFSFGLIVDAGFGILPYNGFVNDTSTAADQADYCNGRGDLLCGRLVDALFHGTLHANLGLFNVLEVGIQLPLAVFGAGPNVTVPGFFNEGGTRSRSLDYQGIGPLSLHVKGRILRAERNGGFGIAALLQVEFPTGSPSEFVGDNNVVLWPIVALEWRPARIVRFGVNVGTRLQLGEGMPIVPAGGRTVPGGSNATMPMQVPGSATSVQYGPMLTYSLGVGIRLGDSPVELTADVYGASIFEAFATEGGTSLEAMGGLKIFVDRNSYLVLAGGGGIPVGGILQSDVRGMIGFVFEPSIGDRDGDGLRDDVDQCPDQPEDFDDFGDEDGCPDPDNDRDGILDVDDECPMVPEDRDGDSDEDGCPEGNEGDRDGDGILDADDQCPDDPEDRDGFQDEDGCPDPDNDQDGILDTDDLCPNDPEDRDGFQDADGCPDPDNDVDRILDRDDSCPNDPETYNGTEDDDGCPDRGTVVIEENSIIILEKIYFETDSAQIQSRSFPIIDAVAATLIGNPHITLVEIQGHADERGDDEYNLRLTSDRAAAVVEALVQRGVARDRLRSGGYGERCPVDPRHTAEAWEQNRRVEFKIIRTADGPTGVEVACPAGRSLIPD
>NZ_CP011125.1|WP_053235398.1|6258435_6260253_-|FHA-domain-containing-protein
MYKLVIADDEGKTTVVPLVRDEITIGRKEGNTIRLTERNISRRHAKLRKANGSYLVEDLSSYNGVKVNGRRIGNEATLKAGDQISIGDYQLALQLDDGATIPDTTAPMAAPNGGAEPATAMLQSPAIAPGAPTLPAGGVGTPAIVVGPPARLVMTSQPAPGAEFALARPVTRIGRAEELDVWINHRSISREHAEVTNDGGAIRIKDLGSANGVRVNGRDVQQAELKPGDTLELGQVRFRFVGPGEQFVFDAAHTMQLEAASPERPTSRAPIFVAAGIVGLAVVGAVVVAISGGQPTSTTATPITEPPVPSPTVPTVHGDPTTAVAGPSVEERVAAAVAACVTARNGGHFDLALQRAGEALAILPSDVRALDCQAGAQQDREESDAFARGVALRNQGNLEGAYLEFDALPPQSPFRTRPEVEQTMRDFADATLEQAQDQLTEEPEEALRLAQTVLNMAQLEPATRRAADAIARRARPRVSGGARDRAVTPPRDREPRDPRGTAGAVTGRDSGTTTSAAVTPPPPADSGQTPLAAARACLARGDNQCAVRALEGRSRTTDEYRLLVETYRAMGNTGRMLDTMERYIQRFPSDPRTQQYRQILLQHGR
>NZ_CP011125.1|WP_169791557.1|6260409_6261780_+|hypothetical-protein
MRWRTTACVVGAVALLGCEERAPAVPTRDSGPRARDGGDVAQIDGGYRRPDGGPRLPPADLEVTLPYGGPEARVPLEVGADLGTLDVFLSIDTTGSFGGEIDALQRDLIDGVVPTLAARVPSVALGVGRFEDFPAEPFGTENDRPFQLVTAITTDRARVGSALASLDAPLGDGGDLPESGAEALWQIATGEGYTHDGRTWIAPFRDRGVPGGGDVGGAGFRARALRVVVHVTDATSHAPGEYEASFPGTRSLAQAAEALRAIDARVIGIASGPAPRSELEALALRTGAVVPPVDGSCSTGIEGAPRGTVEGTCPLVFDVAPDGTGLSTTLVDAIGDLLDTVQWNEVWGEADDEGLGFVRAVAAIEARVEGGAAPPTREDRRPSGDGVADTFAGVRPGTSVRFELVLRNTTVAPADYEQVFRVSVRILGDGLDLVERTVRVIVPRGRLVDGGVDSGA
>NZ_CP011125.1|WP_053235400.1|6261768_6263391_-|alanine:cation-symporter-family-protein
MQALFSARDVLWTWVVPIVLALVGLVLTVVLRAPQLLRLRDGFRAALSHDPRVEGSMPPGTSVLLSSAATWGAAAAVSAATAVALGGPGAIAWLWLFGLLIAPLRYAEVLLARSAPPGKAGEDAHGSLATRLANDSAPALRAIGLALVVLVPLAAFAFVGGVHGGAAADAAGQLLPGSETYVGIAVAVVAALAVLPALGRPVATPASAVLGWIALAALGTLFGVAFAAMLQDPARAFGTIPRAFDDVFSGAESVGAFSGAMVGEIAAAALLHVLPPLAATTGADGAIHAAARAPTARGQAAAALFGPLLHVVLATVLACAFVATGAFHRRVEGSRALDEITFWRSGFDTVSQRRETDRTFSGTLRVLDGGVLARPLELATERGMIVDPRYVGEDGQPGDFALRVTDGRITALLEPDGEGTLRQVDLARTSRIRVEGAMLPRGGTLVASAMMRGGGDIASRIALTALLLLAALGAAGWGVAAARSVPRALAIPAAFLPALGLLLAATGVAPWLATVGSIAGAVLGLVAAIGLLAKLRELRA
>NZ_CP011125.1|WP_053235401.1|6263839_6265315_-|DNA-polymerase-Y-family-protein
MSRIACLDVPALPLQVLRRDRPEWAGMPLAVVGDDRPQAPVLWTSQSAQRLGVRVGMRYASALGISRELRAAPVPEARIAEVRAELVGAMHRYSPRVEPDDERPGVIWIDPEGMVSLFGSLERWAQSIWGELGAHDLFGAVVVGFQRMRAWAIARTVRDARVIADADTEHRLAGRVSIARLDLPPELESALAVLGVATLDDFLALPPGELSVRFGPSASRLHALFSGVMREPMTPVIAAQPIAIEAELDPPDDDASRLLFCVKGALHALHRALEQRSLALAALDLTLTMEGGAAPHREVLRPARASRDATSVLELVRLRLDTISLPERVERIRLEAEPAPLEGTQLVLAAGTRRRDPDAATRGIARLRAAFGDEAVTRARLEDAWLPEHQFRWEPVRTIDVPRRAPDDDPRDPPLVRRLMPSPQPLPSDDAGRPVCVPPITEMSGPYRLQSGWWAHGVVRDYWYAERADGALLWMYRDAALDRWFVQGRID
>NZ_CP011125.1|WP_053235402.1|6265342_6266281_-|hypothetical-protein
MASTLVPRVLRASTVVAARVATLPADRARVVEAAGASLAQLALALDGDEQRIDTAALTRLLDVARIDEARIDEAPAPDVALADVGLAGDASTRETRTAQALAVASSSLRRVRLLRAPTARVPEPPASAPWVSPGRIVELCSGPDSAQTSAAVVVLRDAQREGDPVAWIMPRGAGLFPPDLAAAGIDLDALVVVHVPPDDAAAAPRAAELVLRTGAFGAVVLDLGSAVLPRGTAWQGRLLGLAREHACRVVVLSPHGRSRASLGPLVSLRFDVRRKRVGPDRFGVVASALKDKSGLLATHETRGACLAPVGAR
>NZ_CP011125.1|WP_157069407.1|6266459_6267041_-|hypothetical-protein
MRDDASPEVVAGAVRMVVEPTPHPEPQVRYSVPQGPEDARRRAKGPPAVDIDLVYERRSAPLPDQPWIFLEIWTRNTIYQLDASLICVDVIDQGTRRAIAEHPLRGARLVGGQSRDGDAMELSHPFPRPGSEAVFEQTSGRHVRFSQTSSVTRVVMRLRVLTVEPEQLLPTWEDVSGKWDLRTLGQKPQGQKK
>NZ_CP011125.1|WP_157069408.1|6266994_6267534_+|NAD(P)H-dependent-oxidoreductase-subunit-E
MRTAPATTSGEASSRIAIGCTSSGGSGCDGGPKPGTVPCLGREGGSSLIPRSRLSRVVSPILAADVDGPLFFPTRAHLLLCTGPRCSRRGSTRVFEEAWRTLEARGIAYYKRGGGVRLTESGCLGCCSYGPTLAAYYGDETGALTQAWYVGVDAPSLVRIAEALNEGRTPPDDKRFGPR
>NZ_CP011125.1|WP_053235405.1|6267534_6268722_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MTDRTLRPGTLAVHAGEEPDPTTGALEPPIVLASAYAFASADDAAAQFRGEQDGWIYGRWRNPTVESFERKIAALEGAEATVALASGMAAVNGAIASCARAGEHVVAPRSVYAEAARLMREVLPRFGVETTFVDQTDLAAVEAAMTERTRIVYAETPANPNLVCTDLAALAELAHARGAVLIVDGTFATPWHQRPLALGADLVLHSATKAICGHGDAIGGVVSGSRDRVTEVRRIGVRAMGGAMAPNTAAMLARGVRTLGLRMDRASASAMELARRLEEDRRVARVWYPGLPSHPQHAIARAQMTRGFGAMIAFEVAGGLEAGKRCHDAVEVIARAVSLGDVRSLLTHPATTTQASMPREARIAAGVTDGLMRFSVGIEDVEDLWEDLDRALPSS
>NZ_CP011125.1|WP_053235406.1|6268739_6270281_-|hypothetical-protein
MQRWPSVIALSAAIVSACADEPVIDAAPSDAGVLIDARAMLDARVPDDDAGEPPVACDVVASDGETLERAIAAASPGDTVCLAAGTWRDLVLRITQHGAEGAPITIAAERPGETIVTGTSAIGLGGSHLVLRGLVFRGGRSAGGTLLATRSDVSTPCGHCRLTELTIDGVDEGVEESKWVSIYGDHNRVDHSWFAHKTSSDVLLVVWRPDGAEDHHRIDHNYFGDRPPVGEGAETLRVGTSDTHDTPSYTIVEHNLFERTSGEIEIVSNKSGRNVYRHNTFRASIGQLTLRHGDGCVVEGNWFFADGAPGAGGIRVVGGGHRIVNNYVQGVRTSSDVRGGIVLMSWESDAEPTGYQEVVDVLVAHNTIADSEQSLVLGAGSSDRAPRRITLANNLIGGAIGAVVRSELGIEASTWAGNVLHGDALGLDETPGIRFVDPGLARDGEGIWRPDPRGPAIDTAAAIDEPLAIDIEGHRRDGRADVGADELVDAPARLPPLTAADVGPRTYDPRRRD

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Crispr_ID: NZ_CP011125_26

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_26

7071543-7071673

Orphan

Consensus_repeat	Method
GCCGGCGCGTCCTCCGACGCCGG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP011125_26

>merge|NZ_CP011125|26|7071543-7071673|CRISPRCasFinder
GGTGGGCCGCCGTCCGACGCCGCGCGTCCGCCGGTCGACGGCGCGATGACGGATGCCGGCGCGTCCTCCGACGCCGGCGCTTCGCTCGACGCCGACACGTCCTCGGACGCCGGCGCGTCCTCCTCGGACGC

>NZ_CP011125|26|21|7071543-7071673|CRISPRCasFinder
GGTGGGCCGCCGTCCGACGCCGC	GCGTCCGCCGGTCGACGGCGCGATGACGGAT
GCCGGCGCGTCCTCCGACGCCGG	CGCTTCGCTCGACGCCGACACGTCCTCGGAC
GCCGGCGCGTCCTCCTCGGACGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053236080.1\|7072759_7073272_-\|DUF2505-domain-containing-protein	unknown	unknown	gnl\|CDD\|378476
NZ_CP011125.1\|WP_157069552.1\|7067047_7067821_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP011125.1\|WP_053236072.1\|7064546_7064750_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|365980
NZ_CP011125.1\|WP_169791605.1\|7069680_7071363_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236086.1\|7080543_7081452_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236081.1\|7073322_7074684_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP011125.1\|WP_075097663.1\|7064737_7065319_-\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|334719
NZ_CP011125.1\|WP_053236069.1\|7060877_7062458_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236070.1\|7062661_7063012_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236083.1\|7076011_7078645_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226418
NZ_CP011125.1\|WP_157069551.1\|7065493_7066021_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|223619
NZ_CP011125.1\|WP_053236085.1\|7079302_7080535_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236075.1\|7066031_7067048_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236088.1\|7083723_7084410_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236089.1\|7084406_7087988_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276921
NZ_CP011125.1\|WP_053236084.1\|7078696_7079203_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236077.1\|7068116_7069628_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053236071.1\|7063592_7064366_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236082.1\|7074735_7075974_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069553.1\|7081500_7083513_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053236080.1\|7072759_7073272_-\|DUF2505-domain-containing-protein	gnl\|CDD\|378476	pfam10698, DUF2505, Protein of unknown function (DUF2505). Members of this family are all Actinobacteria. The function is not known.	2.68043e-14
NZ_CP011125.1\|WP_053236083.1\|7076011_7078645_-\|AAA-family-ATPase	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	6.66354e-15
NZ_CP011125.1\|WP_157069552.1\|7067047_7067821_-\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	7.08365e-06
NZ_CP011125.1\|WP_053236072.1\|7064546_7064750_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|365980	pfam00254, FKBP_C, FKBP-type peptidyl-prolyl cis-trans isomerase.	4.8241e-11
NZ_CP011125.1\|WP_053236089.1\|7084406_7087988_-\|hypothetical-protein	gnl\|CDD\|276921	cd13416, TNFRSF16, Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271. TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases.	1.13084e-16
NZ_CP011125.1\|WP_053236077.1\|7068116_7069628_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.15226e-81
NZ_CP011125.1\|WP_157069553.1\|7081500_7083513_-\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	0.000464617
NZ_CP011125.1\|WP_053236081.1\|7073322_7074684_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	6.75177e-19
NZ_CP011125.1\|WP_157069551.1\|7065493_7066021_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	5.01731e-36
NZ_CP011125.1\|WP_075097663.1\|7064737_7065319_-\|dihydrofolate-reductase-family-protein	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	1.24414e-16

>NZ_CP011125.1|WP_169791605.1|7069680_7071363_+|helix-turn-helix-transcriptional-regulator
MRSERAATPCRLARVSEELFRCAAEACEHGTITGARVHPPELLDRLDAVATPEAQAWGWLLRAQHAALSRAGDGALEVPAHVLSTSTSRDVVRRGLPILARLALLAFDATRLERCCELHDLLRDESASDAAAIAATLARAWLRWLRAEPHEHAVDLGAIAAQARALGQPALVVEAQALRALDALAAGDLQAAAELGRRASRMARTEGIPESEVLANVALARVRRAQNRPHLSLRILGALLPHAPPAWHDWIHWEAVAAGLIRLDLPGSSSPAALLAATLRAIGSGVAADVGPCAERLLGAVQAIAPLRHDARRALTLLVPGYAEPDPDVDEWHRGTSVETPVGLAGIAFAPAPGRVEAGTCAHVVVAPGVAARRVAPLAVPMESASAEIDPRPATPPGQPRTDEGLAVLALAGRALETPAYFRAVYEYDYEPGAHATMLGMHVHRMRSRLGDAGTIAREAGALELVAARAMLLRDPRCGEPLAQQTLRLLARGGAVSARALATTLGVPLRTMQRVLAELVTDGDLARVQEGREVAYRVEDTTFSEPTRSQRFGPAGFSVE
>NZ_CP011125.1|WP_053236077.1|7068116_7069628_-|serine/threonine-protein-kinase
MVHVDAPTPDRAGATTRYQRLFDLAEGGMGRVELSVRRGPSFQRLYAVKRLRPAVAADADARAMFLEEGRLAGLIHHPNVVPVLDVGEDERGPFLVIEYVGGITARDVIVEAQRSALPTSVQIGCRIVAQAARGLAAAHDLTSHDGGALGLVHRDVSPHNILIGFDGVVRVTDFGIAKVTGREHRTSSGVLKGKLGYMAPEVLQFRGADARTDLFALGVVFYELLAGRRLYGGEDDGARARRILDEPPPDIGELRMDVAPDAQQLLVSLLAKDPADRPESARAVADRLDAIVHQLVELEGAHPLEEFVREAFGSVQAERQRAIQTALGELAGAAEADPTTTSEATRPALARRWSQRATALALALVLGATGGVVFAVADSGEPPARATTSSDAAPPELPAAAAPARVTIEVETVPPGAWVEIEGLEPVRTPASVELPRSTDRRQLTLTLDGYARRIESVVPDESRHLELVLAALPSPPARERRAARRESPSPRSKRASPLDTYW
>NZ_CP011125.1|WP_157069552.1|7067047_7067821_-|hypothetical-protein
MSRCLLIAVCAMLSWLRTAPLCAQSARPCASPAECEQAAAVLAERAGERFAEGDLEAAVVLLREAIYLHETPALRHNLARSLAELGRWEEARAEYRNALRLALDDEARARMQAEVARLSALIRAGQSDSEASPSTPPAASVSAAPVSPEVELAPGTPFDPAPWVLAGGGVVVLGAAVALAVVFEDTVSQVRSAPSHEAAWPLAERAEGLAIGADVAFAVGGTLALAGVIWGIVVLASASSPGAQALRPSGGGLGAVF
>NZ_CP011125.1|WP_053236075.1|7066031_7067048_-|hypothetical-protein
MRARSILAALALCVGCSVGPDLLEGLPCPCADGWQCDEAAGICIRGAHDGGVDPPRDGATPEPPAPLATTCWVRPEGCDWSREGFTLVDQFGDDRFTDGEARNATFSPDGCSVYYSLRGDIYRVTRSGPREPYGAPEPIASVNGATAYLDAPSLSPDALELFVASDEGVSGTRSVLRAARGTATSAWGPLEEVTALSPPALVTWEPRLAPHGLRLYYAPDDGVQFIHVGERDALGRDFAPPTRVVIEGLEPGYDTNRPSVTHDERVLVGVQQRHADEPTRIGFYVTRSDWNAAWRRAQPLPSSVSLARVGDLSVSPDGCEVLVRSQLSTATTLSYVDP
>NZ_CP011125.1|WP_157069551.1|7065493_7066021_+|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MRALLALVLVLAAGCGARRAQPSTSDEQATNGAETPEPTPPTDGPCSSWDPSADPTTPPLDVAAPPATANRGRDGLRFCILRPGSGQRRPSRDDRVRVHYTGWTTDGRMFDSSHTRGEPASFPLTDVIRGWTYSLESMTVGQVRRVWIPEELAYQGRAGAPAGMLVFDIELLAIE
>NZ_CP011125.1|WP_075097663.1|7064737_7065319_-|dihydrofolate-reductase-family-protein
MTRKMIAALQVSLDGFTQGEDRGEAPWVDSWADAIELIPEVDTFVQGAGMHPGYGAYWKAIYENPRSIPPYQTRAPYEREVAYAQLAAKAPHFVVSTTLDRVEWPPTAKIVRSVAELRGLAHQPGKNIYVVGGATLVASLLNDGLLDELRLIVHPILLGGGKPLFAGIDRRRSLELIDSRSTESGRVILSYRT
>NZ_CP011125.1|WP_053236072.1|7064546_7064750_+|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MLRLCILPPGSGQRDDRVRVHCTGWTTDGRTFDSSHTRGEPASFAPVPFVPAAASSNARRAELRQVR
>NZ_CP011125.1|WP_053236071.1|7063592_7064366_+|hypothetical-protein
MSQLNTPVFGGYVDAMRITADNAQPCARELVNHAPADADPREKKALRRVGDRASEIDEVLKERERDPGVKVRPVVTAFCNGWGGLSDAMLGLTRIPNERGERAAALHARLFPAGMLWLREDARTIWSQGNRLVQRIDEENLAREIDQLIGADVREAVTRVTNELGETIGVGRKRRESVSTTGVQEKLLAFSRAVAFYCRQLAANVDESDPKSIERFRLAVAPIDAYRSTRTVRDSEPPRPEAPAIDPVTPDPVADES
>NZ_CP011125.1|WP_053236070.1|7062661_7063012_-|hypothetical-protein
MTSSRRSRVLAIVVAIAAFVPACAAAPYRTARIEGTAQDGETGTVYFVEVRRGRHVPNGTGDELNTDDEVTAVIVCNDRTPEVCVRVLPDTLRTAEETRAWAQRLNATIDAQSRVE
>NZ_CP011125.1|WP_053236069.1|7060877_7062458_+|hypothetical-protein
MNDSDEQVLGDEAEGVFEMWARRVHIRYGRLEPDRYGIDRWFEIPAPMAPATTTLDRRAGGIQGYLQIKGTRDASRGSDIALSVWDRFVKSDLPCFVLCLEFDEGLNVRAAFLSHVGPAKIPDVLRRLRAARSDDLHKKTHRQKWSRANAIDSPFDLGLVRKMRMHVGDPATYAARKAKIRDTAGYGSGSHRLHVRSRADDEQVVEALLEGHQIPVDILGITETRFGIESPEEIPKAASFGVKFGPSESKPSMLTIQSPTALTMMNGQSRVAGTSALGLPPSREVLRFEAPALRVDVRDSGTTLTVTHLGLERVDDRFSLRDLRNATNMIVNFLRERRTITLEVAGHPHTFEGGVPDRDSAEAFGIAIAFRWAAVAVEMAGLPDDIEVQPREILSQIDELRSWGIHTDRDATHFIVRFATNDFPFNNDFTTVLPAWFAIGRHVIVQAFASEAVPTEPSEADKRQFRLQPVRSGRPHVLDRNAAASFDPVTATLPLREELQRGRPLLALDDDIRRHWREFVEGLTLA
>NZ_CP011125.1|WP_053236080.1|7072759_7073272_-|DUF2505-domain-containing-protein
MRTATESFDLACPPEGFWRVYLDPEYVRALYLGALGYRACEVLEVTDTSRKLRVVPKMNLPGPIEALLGDGFAYEDHGTLDRAKNEWTWRMVQPEQLDPRAKPRKDVVTTRGTIRVTATGGGRCRRTDELVIEAKLFGIGGMIEAVAEKETRAAWAKERALLATWVAKLR
>NZ_CP011125.1|WP_053236081.1|7073322_7074684_-|Gfo/Idh/MocA-family-oxidoreductase
MTRTTSRRAFVELAACGLGAAALPGCGSALAPAPRPSHARAPAPETPLRAAPLERVRVGFVGVGGMGSAHVLNLLTMDAVDLVAVADIVPAHAERARSWATERGRPAPTLYTDGERDFERMIGEEALDLVITATPWEWHVPVMLRALESGVHGATEVPAALTVDDCWALVEASERASRHCVMLENCIYDRLELMTLAMVRAGALGEIVHGQGGYLHDLRAIKFARDGEGLWRRRWDTLVDGNLYPTHGLGPVAACMDIHRGDRLERLVSMSGPSRGLADWARTRVDEADPRRAERYVAGDVNVTLIQTARGRTITLGHDTNLPRPYSRGFTIQGTRGIVEGSPERIHIEGRSPEHAWESVEAYRDEHEHPLWRAELASAHERPGHGGMDYLELSRLVHCLREGLPVDMNVYDAAALSSIIELSARSVAARGAPQDIPDFTRGRWQAWTRGEVI
>NZ_CP011125.1|WP_053236082.1|7074735_7075974_-|hypothetical-protein
MSTLSWMVLGALLAVGAQGCGGGRGDDADGGHRDARASGGDGGGEGSALPVRCPPGADDPVCGQAREDNPIGAGPRPRAQVGLTPMLTGGVLDGETLVIGGSWGGGDALTGAVLEIELGSGDRRALSGVVNDPRTGEQTIGAGRALGQVQDVGVRSDGDVVALSRVSTTRVELVRIARESGDRTVLWYNQLTADGHETTAACTDGAAREIPNVDDSSLAIGPDDEMYVVARPADPSAAAIIAIAADGRSCAITTFDGEAQPPGANRGSGPKITGGMRGLRYAGGRLYGTDAGVSSLIAIDVETGDRVVISRSGSSGTVGAGEALGHSRLDVDVAGGRALTIDDELGGATRITEIDLESGDRTTVALVSNTVHAPGEGGVWFHPSRPLYVAVTWSTAIALVDPVSGEGNLISN
>NZ_CP011125.1|WP_053236083.1|7076011_7078645_-|AAA-family-ATPase
MARGRERGRRSDLVGRDVELETGRALLADGARLLTIVGAPGIGKTRLARALLEDAPHRFVDLAAARDLGDTCAAVAAALDVRALSARSADDLAGAVHEALRTWSGGALVLDNVEQVVDVTASNIERWASASAAPLIVTSREPLRVPAERCLPLAPLSVPASDDHDPERILAADAVRVLLARARARRPSFAPSDSEARDLAAIARAVDGIPLALELCAAQLWLLGVHGVRERVESGIGVLGSAVRAGVDRHGTLAAAIAWSWDLLSEAERDALARLSIARGGLDLEAAIALLERSEADTLAVLHALHDRSVLLVEERDGRARYRAYEPVRAFVSERAELGAARARHATHFAARAIRDGARASSVVRRALLADVENVLAACDHLVDPRSETSDAALGASALAAIAPIYTEGHHGPIDRYLERLDRGGEVIGERDAGARGRVELARGTVRSLRWEIAEADARLEAARTWAERARDRSTCAEAWLRTARLRSIERRHDAAADALARARGAIEVGVDPAIDALHAFEHGSSLLVQRRLDEAHASLARASALYGSLGDAAREARAAANAALALMHAGRGDEAVETADAALAAARREGLRRAECEVLAVRANALLEVGRIADAELAIEESLAIARAIALHSFHAAVRGVLAYVRLFQGRFADALPLIHDTEAAYRASGDRDRAAIAAAIQAIAAGALGRDALARERLAAVRAVDSAAVAEVAEIAEAHVALVLARGDDAIERAASRARALAAPASSHTSDARLLRTLLARAIPELAADLEVGVDARWFRVAGGPEVELLRKRAVRLILDALVAARLESPGVALSTDTLFRVGWPGERASESSAKNRVNVTLTRLKDLGLRPLLQSRDDGVLIPPGVKVAICNER
>NZ_CP011125.1|WP_053236084.1|7078696_7079203_-|hypothetical-protein
MRPAEPARRSRTWISVLGGIAALVCALPALVLVWLEVDMARAHDHPVSHWDYVAQGLLAAAWGLGTALVLFRRSTSVRVLIAPGVCGIAVALIGIAINAQPLLAPVLIGQDREAADWIRVAMIPGFGGLGHLAAQSTRLRGALDRVFYALAFLLAVWIVVRVVVVATS
>NZ_CP011125.1|WP_053236085.1|7079302_7080535_+|hypothetical-protein
MHSLVRSWAPSARAGALVLALGGCSGTHVRHEVDAATASDGGAIEIDAGRDPVALVDAGTSDVDAYVEVDAGGSEPPCEPRILVTARAARVAYFAPRADGYLAVAWSARDAEGARSLALQRLYSTGIARGEPRPIPGEHLTPIQDGLVAYGGSPPMFHHVDANGLAAGEPISAPEDWALVSDVVASGTSVRGTAVHRLEDGTYDTLVYALDVAGRAPEVRDVGDADRELAILGHEGDRELVFRRAGGAAIVERTTLDREVVHEHAWSHEAITPVAARFDASHGVWLVLAEERVTSDVGSYARPAIVALGTRDEERITRVVDARIMRAVVGTIAIGDGIGALAIDDHHGSSSVVFVSLDTLEVLEIREVPEMWRGAIAWLPGESSFAMVTETSPYEPSTTLTFHCGLRPAR
>NZ_CP011125.1|WP_053236086.1|7080543_7081452_-|hypothetical-protein
MARDVVLGRQIAIAARVVDLVVPRRALTVVAFLAAVIVASVGARARAKQDAACVPAPELSFTTRITRWPASGRTQVDHRFATLRAWDLDGDGRADALVPRPRERAPEGTCPGEVRWDVYATRGTACDVLLGTVEGDAPHAEAVRPGHHGLRDLVTTIAPATGAEGATRIRYEHDGTRYVEVSRTRGPARCDVHPDACRDVPHATCDLRDHPSVPGRFDADGTVLAMLRASEAAQVACRAPAATIERCDVHVSFANDGRVTAVDVRDCPRRRACVAPFFQALRTSPFVGDPAFPSTSFQIPAP
>NZ_CP011125.1|WP_157069553.1|7081500_7083513_-|hypothetical-protein
MMRAGSFVFWSALAALTACTPAPADPRPDPDAGADTPDVGPEVPPDPEPADCVEPEVGTVDEDVSEPDDSALVRRVHELARAGQSIATSAFPRETAVRVAIDIDEDAIRTAADGSTYAELDIDGTTVHVVNAGSPTARPTSSDLALHIGSRELVGASIVASFTETTRGFELSLSSMDASGAPARPVGPPSRTQPPGCLTTAFQGLAPQIPRDMPPIRLPALTGCEDLTRCSQIRAAWARAHIETFWAYLMVEWLETRSFADREFAWGAQGRDVHGELTERNVAPEWWYGEYDTGRFERVHEGVEDVWRVFRTLKHGRQTVRLYCPPAGETNVCNVGSPPSAHHFDRGELNFCARFFTDHDADSRIRLMIHEPLHWIFVGGAALLDRHTHGHGSDCLTAIEHVDAIYGPEEAHELASYVAPNGNECLHRDMASRAVDVYAQMIHHFGRAVRTREMVRWPSNGDPPPAPCDAAGEEGCICAQVPSTGAPDGDYLPTQFCPDHDGEMTCVTTTFSASTTVGVCTRCQPAGDGGNNRPAGCECESDEQCATGLSCYGADTQGGGGLGHCYRDDRGPPDFACVADCRRLFNDPQAVCIHDYPGGARCFELACDDPGVFAPCYENGTGVCRTACDSEGNDCETGCGSECVNDTDCDERGYPAGYSCVGAVCTFTGT
>NZ_CP011125.1|WP_053236088.1|7083723_7084410_-|hypothetical-protein
MSADDGTRIAPAARLPDGTPSVQWMITDSIHTVASRATPYLESARLFGDRYGMLLALIDAFRDEDGRAPELQRALEVARGLLAQGKRHLHDAWDARTGPAVDRRLDEIFREATPPRGTVAARRSEAPIDPFATVAAVIQKIDRAPDRAEAATEFAVTWALLRRTPVRLRELREQAGADDRELLDAGIRSAGRWMLDLEEAWSARTFDELLGRPTLGELLQLVFPPPSE
>NZ_CP011125.1|WP_053236089.1|7084406_7087988_-|hypothetical-protein
MTVDVRGAAHVADTPSGIHFADASSGLGLRYGHGLWVDASGQETRIPARWRGDRIELVVPSDVVGAATYPAVLDPVISPEVGLDTPVLSPTSGTKTDPAIASNGSGYLVVWTETRADTPAVFATRVDASGTVLDPHGILVSGSTSSQAMPAVASDGTDYFVVWQHANADFDVYGARVTSAGAVLDPSGIAVHRTSSQDYWPSVAWNGSHYLVVWQRAAFADNNVLGIRVSRDGALLGSAFSISSATGVQSEPRVASNGTDFLVVWRDGRTSGEGDVYGARVSASGTVFDASGIALSTAAGAQLEVSVASNGTGYLVVWSDGRAGGFHYDVYATRVSAAGGVSDPGGIAISAGSAAERRPNVARAGSDYFVVWSDERAGGGTSVYGARVTSVGVVRDPGGLAISTRGATPTVATNGTALYVTWLASRPPPEALAANELYGTAVTLAGAPADPSGTRLGGAANAQRTPSVAYDGTSWLVAWADARGASWAVWGARVDPSGAVLDPSGIAISSGTVERRSPRVASDGEGWLVVWEEESSADASDVRGTRVTASGAVSNPSGIAISTASGAQTDPSAACDPARCLVVWTDARTSGGRDVYGTFVGASGAVSHPSGLGIATGGHAEHSPRAAFGASGYLVVYEDQRTSQADVYATFVSTAGAISDPSGFPIATRTEYENAPAVAASATSYFVVWSYGLADVHIRGTVVTSSGVSGPTPITIHAEAGSRGAPEVASDRSDYFVVWRDYRGGSRADVYGARIVGTSVRDASGLALATSPFSEQSAEIAAGPPGRFLLVYDRFVAEVPERTRRIRARLIDDRTPLGSVCGSSGDCASGHCVDGVCCDDACGGGATDCLACSVATGAPGNGACAALTGTACDDTNACTISDRCAAGSCGGANACDAATTCAPGPGATYACSACPAGTYSADGTGATACTEWTTCAPGTHVASAGSATRDRTCVACAGGYSSTTNAPSCTPWTDCVPGERESSAGTPTSDRVCVPCSSGWTSAPNAATCVAWTDCAAGQYVAAMATVASDRVCAACPAGTYSTSVNAPSCAACTACPPGAHETSACTATRDRVCEPEAPLDGALASDAGTLPIDAAPPEIDAGRTLDGGSPEAPGDAGCACRAARSGGNAGLAFVGMAIVLVAVRRRRRRRGADDPSGTPSEGAASRCASSAVALRDAERVCRRRPVSGTLGR

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Crispr_ID: NZ_CP011125_27

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_27

7168038-7168138

Orphan

Consensus_repeat	Method
GTGCACGCGACGCCGTCGTCGCA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP011125_27

>merge|NZ_CP011125|27|7168038-7168138|CRISPRCasFinder
GTGCACGCGACGCCGTCGTCGCAGCGGTCGTCGTGCGTCTGGTAGACGCAGCCGAGCCCGAGGTCGCAGCGCTCGCTCGTGCACTCGACGCCGTCGTCGCA

>NZ_CP011125|27|22|7168038-7168138|CRISPRCasFinder
GTGCACGCGACGCCGTCGTCGCA	GCGGTCGTCGTGCGTCTGGTAGACGCAGCCGAGCCCGAGGTCGCAGCGCTCGCTC
GTGCACTCGACGCCGTCGTCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053236162.1\|7178838_7181382_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226418
NZ_CP011125.1\|WP_053236161.1\|7177038_7178838_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225829
NZ_CP011125.1\|WP_053236164.1\|7182302_7182863_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NZ_CP011125.1\|WP_053236152.1\|7162134_7163013_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223999
NZ_CP011125.1\|WP_157069572.1\|7183971_7184520_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236150.1\|7160403_7161420_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|225109
NZ_CP011125.1\|WP_053236155.1\|7166784_7167570_-\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197319
NZ_CP011125.1\|WP_053236165.1\|7182849_7183914_-\|beta-N-acetylhexosaminidase	unknown	unknown	gnl\|CDD\|224389
NZ_CP011125.1\|WP_053236160.1\|7173115_7177042_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|274782
NZ_CP011125.1\|WP_053236151.1\|7161478_7162138_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236157.1\|7168863_7169697_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP011125.1\|WP_053236163.1\|7181463_7182306_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP011125.1\|WP_053236148.1\|7154768_7155440_-\|DUF998-domain-containing-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053239008.1\|7155932_7156280_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP011125.1\|WP_053236159.1\|7171429_7172920_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053236149.1\|7156367_7160291_-\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|320687
NZ_CP011125.1\|WP_053236154.1\|7165285_7166638_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053239007.1\|7155436_7155910_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176868
NZ_CP011125.1\|WP_053236153.1\|7163023_7164901_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|274455
NZ_CP011125.1\|WP_083458587.1\|7169696_7171277_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053236162.1\|7178838_7181382_-\|hypothetical-protein	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	6.96505e-23
NZ_CP011125.1\|WP_053236161.1\|7177038_7178838_+\|hypothetical-protein	gnl\|CDD\|225829	COG3292, COG3292, Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms].	7.75288e-12
NZ_CP011125.1\|WP_053236164.1\|7182302_7182863_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	3.81744e-18
NZ_CP011125.1\|WP_053236152.1\|7162134_7163013_+\|alpha/beta-hydrolase	gnl\|CDD\|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	1.64053e-10
NZ_CP011125.1\|WP_053236150.1\|7160403_7161420_-\|diguanylate-cyclase	gnl\|CDD\|225109	COG2199, COG2199, c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms].	1.86679e-25
NZ_CP011125.1\|WP_053236155.1\|7166784_7167570_-\|exodeoxyribonuclease-III	gnl\|CDD\|197319	cd09085, Mth212-like_AP-endo, Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes the thermophilic archaeon Methanothermobacter thermautotrophicus Mth212and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Mth212 is an AP endonuclease, and a DNA uridine endonuclease (U-endo) that nicks double-stranded DNA at the 5'-side of a 2'-d-uridine residue. After incision at the 5'-side of a 2'-d-uridine residue by Mth212, DNA polymerase B takes over the 3'-OH terminus and carries out repair synthesis, generating a 5'-flap structure that is resolved by a 5'-flap endonuclease. Finally, DNA ligase seals the resulting nick. This U-endo activity shares the same catalytic center as its AP-endo activity, and is absent from other AP endonuclease homologues.	5.40423e-121
NZ_CP011125.1\|WP_053236165.1\|7182849_7183914_-\|beta-N-acetylhexosaminidase	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	1.05265e-79
NZ_CP011125.1\|WP_053236157.1\|7168863_7169697_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	3.78886e-08
NZ_CP011125.1\|WP_053236163.1\|7181463_7182306_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	5.83834e-20
NZ_CP011125.1\|WP_053236160.1\|7173115_7177042_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|274782	TIGR03788, marine_srt_targ, marine proteobacterial sortase target protein. Members of this protein family are restricted to the Proteobacteria. Each contains a C-terminal sortase-recognition motif, transmembrane domain, and basic residues cluster at the the C-terminus, and is encoded adjacent to a sortase gene. This protein is frequently the only sortase target in its genome, which is as unusual its occurrence in Gram-negative rather than Gram-positive genomes. Many bacteria with this system are marine. In addition to the LPXTG signal, members carry a vault protein inter-alpha-trypsin inhibitor domain (pfam08487) and a von Willebrand factor type A domain (pfam00092).	2.95759e-122
NZ_CP011125.1\|WP_053239008.1\|7155932_7156280_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	6.05655e-17
NZ_CP011125.1\|WP_053236149.1\|7156367_7160291_-\|M48-family-metalloprotease	gnl\|CDD\|320687	cd07328, M48_Ste24p_like, M48 Ste24 endopeptidase-like, integral membrane metallopeptidase. This family contains peptidase M48-like proteins that are as yet uncharacterized, but probably function as intracellular, membrane-associated zinc metalloproteases; they all contain the HEXXH Zn-binding motif, which is critical for Ste24p activity. They likely remove the C-terminal three residues of farnesylated proteins proteolytically and are possibly associated with the endoplasmic reticulum and golgi.	7.01528e-27
NZ_CP011125.1\|WP_053236159.1\|7171429_7172920_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.49818e-95
NZ_CP011125.1\|WP_053239007.1\|7155436_7155910_-\|SRPBCC-family-protein	gnl\|CDD\|176868	cd07826, SRPBCC_CalC_Aha1-like_9, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	2.66447e-58
NZ_CP011125.1\|WP_053236153.1\|7163023_7164901_-\|GTPase-HflX	gnl\|CDD\|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	1.13993e-162
NZ_CP011125.1\|WP_083458587.1\|7169696_7171277_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.06315e-77

>NZ_CP011125.1|WP_053236155.1|7166784_7167570_-|exodeoxyribonuclease-III
MRVSSWNVNGLRSIAGKGFSDWLATSGSDVVGLQETRCRPDQVPGPIRELPGWHAHFVCAERAGYSGVGLLSKLAIDGVESSLGVKTFDVEGRLQLARVGRLRIANVYFPNGSGQERDNSRVPFKLRFYRRLHKLLEPYKQDGLPILVMGDFNTAPHEIDLARPKDNQKTSGFLPEERRELVRWLETGWVDTFREFEKGPGHYTWWSQRFGVRERNIGWRIDLVLASPGALPYLRDAAIHAQVPGSDHCPISVDLDDSVIG
>NZ_CP011125.1|WP_053236154.1|7165285_7166638_-|hypothetical-protein
MRSTDILARLYDGLSRRPRPEDVAELILEQLDGRLNARERVALETAARGSLRRNAWGFSSMLADFRRADAITAKVDRAKQLFASASSFAITRDECGDPVKVEAFLRHVAPEIRASFGEIDWKRDRLDRRGRKAEGLDLSRRKYNRKFRLLRRLEERLASLVRVRRQVELTMIGKSSLASRVPRDRFLANASTACFVAYYASRASLRSEFTNGPQQRAFDDISAMLIARCERDPDTDWLVIAHVLPRPEVLARVHDEDKLALLATWHGVLDETAELLRVTWEKSRFRRDTMIVKRGDDSSTWNQLAGAWNKARDGWIALLHVLGMEDVLDAMCIGKVLRLMAADVAHWHRASGGALEPDTAVWSALPPPWEVLRGEAWCTRAHVEETCRAVGVDPTAKGWIAPRPKGEPVPFRPTPELVHGVSVGHPALARMLRRAGWFSGQVERLRPLGA
>NZ_CP011125.1|WP_053236153.1|7163023_7164901_-|GTPase-HflX
MTIHGNTNGLSPSDLHALERLYRRRVPFDRLLTPELARSMAEISASTGRQVGVIADRSGHVQFVVVGDSSKLMLPDVGRVRAAQGRFRGLRLIHTHLTPEGLTRDDLVDLTRLRLDLVAAINVGKNGEPETVHYGHNVPVAPGSSESPHRTIGPLSYQALIGELVQVDPAALIAGLEQEFARVARTRVVDAKDGRAILVHVCEKHDAWRAEESLRELAELARTAGVEVVDQVLQVRDRIDPKFVMGRGKLDEIVQRSMQVDASVLIFDRNLGPAQAAAIAKAIDLKVIDRSQLILDIFAQRAESRDGKLQVELAQMKYLLPRIGQKDDSLSRLTGGIGGRGPGETVLEIGKRRARERISRLESELEKLAVQRRNRRQRRNRRDVPIVSIVGYTNAGKSTLLNALTGSETIVEDKLFATLDTRSRRIRFPEEREVVITDTVGFIRDLPVDLFAAFRATFEEAQDADLLLHVVDASDPALGEHIKTTEQLLGQLELSNVPTLLVLNKCDRVPASEVASMVRARDAVPVSAIDPSTFGPLLERLERMLFERGSGVVTRSATGSDELDLDDAIPPSITSVRLTAARPVEEAPAPRGPYFDDAAIDALIAGSGSKSAPAAAPARTRSRAR
>NZ_CP011125.1|WP_053236152.1|7162134_7163013_+|alpha/beta-hydrolase
MKRALVVVALTFAACVQIETFFFAGRSIDAYRWDEAAPELDGDLSDAHPSIVPAADRIEGFVALDDEREVHWVFARRPGATTTFVYSHGNGPHLGRFWDRVERLWELGHHVLIYDYPGYGRSTGESSEAALYEAIDAIWDEVVPSIPEIDPTRTLLYGHSLGGGPTFHLAARAQRGAPRPRGVIAESVWCSIEAQIQEGAFLDLPRELLAHLAIDNCARASELDASTPITLLQGTEDDVTSPRQSELLESAATRAPVTRILVEGAHHTDLPNVAGDRYREWIDEAVAHALSR
>NZ_CP011125.1|WP_053236151.1|7161478_7162138_+|hypothetical-protein
MRRPFLALALAAIGVVATSACATRQLARTVGRGRTEVGVLVGGPLQSNLGFAAPIPEHRVHGRYGLTDDLDLSASVPLAPIVSSILALDVGFVAQIVRFPRFAMSASLRLHCVYDLDDAWNDTYYPELGVHMEQRVERRVAIIAGTSALVQASPPDQRPGVFLAPYLGLEVLLGEHALSLALGWINPWMDGSSIVTWEPAGFGAMTVTFGWRIQPGGVR
>NZ_CP011125.1|WP_053236150.1|7160403_7161420_-|diguanylate-cyclase
MVDAKVTLHVLIDLHRALTNEPSLEKQLDRVARAALALLEADHASIRVLDETGTELLSGARAGTGVQYRPVTFGRGVGVAGWVVDHNETVRIDDVTTDARFVDVRGQGFAIRSMLAVPLAITGAVIGVLVVTSERVGAFDASKEDLAILLASIAVSPIERARLEEIALRDPSTRAFGARYLAPRLAGEVHRAREGRVALSVIALDLDPLPELREELGRAAIDALLRVSVDRILAVVRARGVVIRRDGGELVIVLPQHDADDAERMADRIGDALAKRVTELGPGLEALELTASFGVVQWDGAESPTRLERRADDALRAAKQRGPGAIAVWPSGERALEG
>NZ_CP011125.1|WP_053236149.1|7156367_7160291_-|M48-family-metalloprotease
MGAAESWTRESEPARQPTLDDLFPPSPSAPPAELTAASTAYKRSAWLACAGLFGFVAVYLGLIAYLARVVYRLLGNAIAHGGNVLLAAGISLPALFFIAFLVRGLFVVKHAKDPSLVELDEQREPLLFAFLRRLADETGAPRPHRVFVSARVNASVFYDLSFWNLIFPSKKNLEVGLGLVNALTLDELKAVIAHEYGHFAQRTMAVGRWVYVAQQIAGHIIVSRGVFDRVLSFISSIDIRVAWIGWIMRLFVWAIRSVLDTVFRVVVLAHRALGREMELQADRVAVSVSGSDSLVHALHRLGPADEAWEEAIAFTHEEAVAGRPVADLLSVQSAALEHLRRILSEPGFGLTPDRPESAAVHRVFDSELAQPPRMWMTHPPNREREEHAKAIYLGSSLDPRPAWALFSDPETLRREITRSFLALLFAKIPNASAEPVPEAQSLAKFEERFARASLDPRYRGAYLGRAIAAYHESPELMVSIDREDGDREALLARFEALYPSSLGEELAKYRERREEESLLEGLSDGVLTAPGGVIRYRGREIPRKELASVIEGVRSERREIEARILEHDRACRAVHLDAARALGGGWEAYLESLHALLHYATHAFRDLADAHGHLHHVLRIVLADGSVSSDERVRVLSASSDLQHVLEQVWSQKPQLVLPPAVRARFADLGGFTVLEDSLGMNDPSPENLGDWLQKVDGWAAGASGDLKALADATLDALLDVEEAIARQLREGIEPGEAPEPARVPERYRTCVVGAERERQKKLGWWDRFQTADGFLPGAARFAVASALLLPALLIGGRIGGSTVHVFNGLPIPVVVSIDGDEVDVGARSAATLEHDASEHAHVVTRTRDGRVVEDFEASVGGGFAEYAYNVAQATVLVQWTAVYGPGLPPPERVLGAPRWRVAEEDAVFTAPPTSVSVSSHSSSARRTVLEAVASAPPASQLSALTTEDDRLAMLRAHVLFDPVDSQAFGEWVAFASQTPAMLPVLRERAQIEPEAVLVARALQDAGDPEACPRATVRATERPDDADRAYVAIRCMTDAQARRAAYARLYEAHPENGWTAFAVAHDLARAQRWQDALVAWSTAVQTPALRGLLDYARTEMLRTQRAAALHQDPAGARAFIEAPDGSGGMLDFFLRLESPPHADEPPAYAAYRQLASGAVLHAVQAIESAVPDAAGRAPLVALAAASDGASGDLVQRALSLDPESLGPPGLHAVAALAIREHRDPSPYLARLRAVDDDHVYDGLADVLASPTLADDPSALEAIASRALLATRGHVIAMGVIVLGDRAPTSWRDEARALLFAPERPYFR
>NZ_CP011125.1|WP_053239008.1|7155932_7156280_-|winged-helix-turn-helix-transcriptional-regulator
MHASFAALAEPNRLRIVELLRTGPRPVNDIAERLELNQPQVSKHLRVLKEAGLVDVQPRAQQRLYALEPRPLRELHDWIERYRRVWDARFDAMDEVIAELQRDDEARGRKKTKKG
>NZ_CP011125.1|WP_053239007.1|7155436_7155910_-|SRPBCC-family-protein
MELRGDREIIIARTFRAPPRIVFEAYTKPEHVKRWWAPKSLGCEVTSCEADVRVGGRYRFVTRAGGQEFAFSGTYTEVSSPTRLVYTQVFEPMADAGHAVVTVTFEEHQGTTRYVSHELYPSAEAREAALASGMEHGMRETMRQLDEVVASLVGDAR
>NZ_CP011125.1|WP_053236148.1|7154768_7155440_-|DUF998-domain-containing-protein
MSAVARVEASSAPSSSAVAARLALGAAAATLALLASLHVLSPELDPTWRMVSEYAYGRFGWVLSLMFVAWGLASWALALALRPRVSTRGERVGWAFLVLAGVGQAMAAVVDVQHPLHSLAALIGIPSLPIAALLLTAPIARERPALRWAAHATWVCVVLMAAAFALLITTFVQAGGDTSAEPGTVTTLPPGVIAVVGVANRLLVVAYCAWVASVAWHVAPRSS
>NZ_CP011125.1|WP_053236157.1|7168863_7169697_-|tetratricopeptide-repeat-protein
MRIIATLALLATLLLAPSAHAQDPDPARGAAARALFQEGVGLARRGDYTAAIDRFRRAQALRPAAPIAYNLAAALAHEGQLVEAAELLERVLRDPTIPPQLRASAERQRDQIAPRVGRLTVRLDGDPSGVRVHIGERELPEAMVGVPVPIDPGAHEIRATRDGADVARERIEIGDAERRELALTIPARVVPREALTVAPARASSSDRAPDAALETAERDPVDRDEGGGGGDDALVITLAVVGGLVVAGAVTATAIVLTSPQTPEPVMGNTMPGVLTW
>NZ_CP011125.1|WP_083458587.1|7169696_7171277_-|serine/threonine-protein-kinase
MSRPASAVANGDQEREHDASGPRLREPILDVEFDVPRSTAEIAAELPVLRRFAGYEILGRIAVGGMAEVFLAREHGQAGSVRQIALKVIRPQLAADRDFEEMFMREGKVALGLRHPNVCHTYRFGMESGHPFLAMELVEGVTLRDLSARARRAGKPMPAPIAVKIVSLVAEALHSAHVARDDKGRALGIVHQDVSPHNVMVAYDGTVKLLDFGVASTSKERATEIAESSHITIRGKAGYLSPEQCLGQSFDARSDVFSLGIVLHELLTGQRLFARAQSLDAMRAITSEPLPPWPTTIPPALQRVLTRALARDVSDRYRTAAAMQEDLERTLAETRTAVTSAKIAEVVARLLGDDFGRAPKLETTRDVVAWIISPEQELIALQLPPPMPLLPPPTPTAPELPAAPPPSSARPLALAATGVIALLLGALAMFAMTRGASAPAATAPAPVIAPIVAAPPPATTAPAPVAIPETPPAAEPVAATPEPVAAAPAPARARPARSFPARPAARAPRAEASSEASSEFFDDPGF
>NZ_CP011125.1|WP_053236159.1|7171429_7172920_+|serine/threonine-protein-kinase
MYLRLDRLSDAVRSRRTRSLILLAASIPLWLFGLASFGMIAMWAVEPTPTPDWGAASFCATFGGAIPCLGAIALLFARHRYDRGTRALQALFTEAGSDGRVDRAALEARGWTRERADAVLLDALAHGLLRETASATPQPIGAQALAPVAGPPPFAWPQPPPSPSPVPASSPPYVSPVAPGAVMSPPPAPSPLYELADPVAMTRDARARAATASPASSALTGRVLKSTYLVEEPLGRGGMGAVFAARHLRTGRRYAVKTLLSTERFSREAILRFEREARAASAIGHSGIVGVHDFDRTDDGMHYLVMDLLSGETLETRLGRSGRLAWSDARRVAIELGDALAAAHRAGILHRDLKPANVFLAHVAGLGERAVLVDFGLAKPMEESAAQRVTSTGAVVGTALYMSPEQARGAPLDARSDVYGLAAVIYEMVTGVPPFLGPNALAVMTMVMAEQPVPPSMLARGLPAAVDHALLRALAKHPDQRPSDVASLVSMLAAIA
>NZ_CP011125.1|WP_053236160.1|7173115_7177042_+|PQQ-binding-like-beta-propeller-repeat-protein
MLLAWTIGGIALLLDGCPTPASNPRASTTAASAHEHDHFVAIEGHTPREIDHQALIRDALAGVPETDDGSIEHRVPVRRIAIPHPPRGGNARFDWGGGRRGWITALPSEELLTSAAYANGRVFLGGGFASHRFFALDAYDGELAWSVAAPDGGPSAAIVANDRVIFNTESCTLFVADAGTGEIRWSRWLGDPLMSQPAAAGGLVVSAYPADGAYRFGAFRLDDGEPVWSTAIPADVIQAPQIVGDSVYFATMDGSVLELALRTGEVRWSRDVGASSAVWVDRGSVLLARRVDMQEQIVVLSARDGRVARTGDRFAAPYLSGQSRDRALVHAQAGAWGNFQHGDHLGLRNVAAGWAFQGSTPTVADGRAYFAIGDAILARAIDTGEEVWRRTYARAGGAQALSPPAIVGSLLVFGTVDGQLVATDVDTGMTIWAYEIGEPIVFQPIVAQGWVYATTARGNVIGLEVGDAMLDGWHMWGGNERHAGPVETAGTVDPALLASLARPTRGTLRAVAPAVAEPDVDGDEGEVASDATPAAIPPPAPERDLPLRRTSIDARVSGFVAEVEVTQEFVNDGDAPIEAVYLFPLPVDAAVDAMEMRIGERVVRGRIQGRSQARRTYEEARATGRRAALLEQQRPDLFAQRVANLMPGDRIEVRLRFVQPLPFESGRYEFAFPLAAPRRFDPSDASAVAQQPEEPDARAISMSLAIDAGLPIGTIESPTHDVAIERGARPSIASVRLEGERVPNRDFVLRYTLGGDAPRATVLAHRGAEEGWLTLLVQPPDAPADETIAPRDLVFVVDASSSMRGRPSEQARALVHRAIGALRAGDTVDVIGFADRVVRMGEHAAGDADATARADEFLAQLRTVGATRMVPAIEEALDRANAASVRAPGRVPLVVLVTDGYIANEAEVLRAIATHLGASRVYALGVGSSPNRFLLERSAEVGRGRALITTLGEDAARAADRFHAWIDRPVFTDVEIDWGGLDVQDVHPTRVPDLFADRPVVVNARFVRGGRATVRVRGSVNGRRHERAIDVTLPSEPTPDGPHASQESLWARAAIGDRIRRLEVRDDEDLVREVTELGLAHHVVTPFTSFVAVEETPAEPSEGEPEAEVRATVSPARALPGDPEIRIPAPPDARAVTVILPFGETIDARWEPAIDRWTARFLIPRDAAEGTFPIEILVTHADGHAEELRVFYTVDASAPEVAIELDGEARPGATITVRARQVITEADLAQVGRRAIDPQRAQLLADVRRVEVRAPGGAPVALVLTGPGTWEGALRVPDDAEGTMTLELFVADLAANVSTRRVPVEIAR
>NZ_CP011125.1|WP_053236161.1|7177038_7178838_+|hypothetical-protein
MRLVVVVAVLALACVARAQPRLEVVETIGATGDVHDVAVMPDGRVLAATSGGLVVIEGGRVARTITSADGLPGTRLRALDVIDGAIWAASIEGVAELDGALSVTRTIAIARARRVVRAHGALWIATYGDGLFRVRDGAPEPVTLGSDPAYARQTDALARPDGLWIATAGRGVVRLDANGVIRGRIRQAQGLSHDLVWDLEPDGDDVLVATLAGVSRVTADGAITARADETRAAQRLAVRDVRTIRRAGARTIVASWGGGVAELDGSRARPVRGASTRARAVVAQGDLTWIADDAGLTRVERGVAQRVLGGGLPSADLTALARFEGAIWIGTFDRGLARMDASGRIEPVRVAIDRWRVDPRINDLAVTRGAEGARLWIATDRGLFVHDGRRFVPIDDPEGPGDGHVTALHVDRHGALWAATSRVLARRDGDRWQRWSGDDAMPIAQLHAVTTDARGTVWVGSLHGLLRFDPSTGRFARESVATGALPVDWVTAVAPWRGGLLAGTYHGGLVTHTSGRFVIEREGATLPCGWINPHAIETRGERAWVGTLEGGLLVGAPGAWSRIGRDEGMPGDDVTDVLAIDEHEAWIATRAGLARVRVE
>NZ_CP011125.1|WP_053236162.1|7178838_7181382_-|hypothetical-protein
MPPPSEAFVGRARELAEVEALLARGERLVTITGLGGIGKSALAQRVSAGDLDVVLCDLDDATSVEALADVVASSLDAGPGGKTRGTSWPARAIAARGPLRLVLDPLDRVPGAAARIAEWLAAAPELVVLAVSRERLQMAGEIAYEVGPLATDDDAIALFVDAARAQRHGYAPSDDERRVLAEIVRELDRVPLAIELAAARLAVMGPAALLHRLRSRFEILRRPGRGGRHGALEASLAWSWEILEPWERDVLAQCTVFRGGFGIDAAEAVVVTSAPGAPAVIDVVAALRAKSMIRAQSIEHGELRLSLYESVRAYATRGVGEGARDLEARHAKHFVEQAELWAASVETRDGDEARARLALERENLLAVVERILGRGTVSARIAELALRALVALAPVLSVRGPLELYARHLERALEVTAGSGADPRLQARGLLVRGALRRQRGDVTGAERDLGEALVLAHHTGDAAVEAHALLAVSRIAAQRGDLERASSAIDRAIAIGDPGAAARGWIARAALGRARGDREATRDALERARARAGRSVQLEGTIRRRLALVELSDGRLDDARAHLAVARELAGALHDRRGHAVARALCGLADHLEGRVDGAERAYRDAIAELATGGFVTLEAIVAGLLGVVHAERGDRAEARLLVQGARAALEDGDAALEVFFTCVLARIETLAGRDAAARALLVAARARITSATDASLWTLVDAVEASVGSALERDASASLAMTLIARLRAPSARSQPPERADALRIGDAGSWFRVGDGARVELATRKPLRRILDRLALEHASAPGRAVSWDVLIEAGWPGEKMRADAGAHRVRVAISTLRKMGLRDVVKTVEEGYLLDAQVPVVRG
>NZ_CP011125.1|WP_053236163.1|7181463_7182306_+|alpha/beta-hydrolase
MTTTHFAQRSEGRLAYVDQGPSTAPAVLCLPSLGDTRAQYRRIAPRLLDTGARVLAADLRGHGESDATFARHDVRDLADDLVAVLDAARVERAVIAGSSISGAAALLAAARHPERIAGLLLLGPVARDLPLRRVLRPLFRPLFGAPWGPTLWSAYYRSLFKRHVPEDLDAHRATLRAMLGDRARRHALVELLRSDRRDVEQSMSAVRAPVAIVMGSADPDFPDPRAEVAALERALTATRVRTTTLEGVGHYPHLEDPDAVLAAYRALVAGASRTVEGVAS
>NZ_CP011125.1|WP_053236164.1|7182302_7182863_+|TetR/AcrR-family-transcriptional-regulator
MRSSRTDEVVDVAIALVEAEGEEGLGWNRVARALGVKPPSLYNHVESGADLRRRVAIRGWERWEDDARRAIARSRGPRAQLRALATSYRTFAHEHGALFAVLGSTRIAPDDPDFRPVAGRLLALFEAPLAELGVPAAKRVHAIRTVRSIVHGFVHLEAAGQLAMDASIDASFRYAIELLLDGLTSE
>NZ_CP011125.1|WP_053236165.1|7182849_7183914_-|beta-N-acetylhexosaminidase
MTNDAIRRAAGRVLIVGFPGRVLPAPLAALAAEGALGGVILFKRNLGTITEIAAVIDAVHDAFGAGHVPLVSIDQEGGRVARLGAPFVKLPPMRVLGTRDDVALTRRAARVLGTQLRALGIGVDFAPVLDVDTNPANPVIGDRSFGREPDVVIRHALAFAEGLGDAGVLACGKHFPGHGDTDLDSHLALPRIAHDRARLDRVELAPFRAARAKVPTIMTAHVVFDAIDPTVPATLSRAVIEGVLRGELGYDGVIVSDDLEMKAVADRWGVAGSAVRAIDAGCDALLVCATPERVIEAHAALVARAERDDAFAERLDVAARRVDALPRVPRPAPDVLARIDAAGGAEIERALTPT
>NZ_CP011125.1|WP_157069572.1|7183971_7184520_+|hypothetical-protein
MSREIELFVEPAPSAGYRDSPRAGTLRIEHTWRDAAAWRGAPAALPWLGVGIALGALGVRAGGDDPRASLALLGIVAAWLSLTVLFAWEVLARLVNRTRITFDQRALRVVHGPVPLATLRSLRIVRSEIAAFFVEPRRTERGELVHHVAVETVAGVRTTLLALACARRAVTVRDALARHLAA

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Crispr_ID: NZ_CP011125_28

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_28

7383466-7383612

Orphan

Consensus_repeat	Method
GTTAGGAACACCACGGCGACGAGCCACACGCGGACGCGCCGCGCGAACCGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_28

>merge|NZ_CP011125|28|7383466-7383612|CRISPRCasFinder
GTTAGGAACACCACGGCGACGAGCCACACGCGGACGCGCCGCGCGAACCGCGCCAGACATCGAGCAGCAGAGAATTTCTGAGGAGAGCAGGAGGGTTAGGAACACCACGGCGACGAGCCACACGCGGACACGCCGCGCGAACCGCGC

>NZ_CP011125|28|23|7383466-7383612|CRISPRCasFinder
GTTAGGAACACCACGGCGACGAGCCACACGCGGACGCGCCGCGCGAACCGCGC	CAGACATCGAGCAGCAGAGAATTTCTGAGGAGAGCAGGAGG
GTTAGGAACACCACGGCGACGAGCCACACGCGGACACGCCGCGCGAACCGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_083458000.1\|7388654_7389323_-\|metallophosphoesterase-family-protein	unknown	unknown	gnl\|CDD\|378975
NZ_CP011125.1\|WP_053236310.1\|7394148_7395930_-\|DnaJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|365959
NZ_CP011125.1\|WP_053236294.1\|7376420_7377068_+\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|379311
NZ_CP011125.1\|WP_053236308.1\|7391286_7392087_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069602.1\|7379492_7380761_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366051
NZ_CP011125.1\|WP_053236304.1\|7386919_7388653_+\|tryptophan-7-halogenase	unknown	unknown	gnl\|CDD\|380163
NZ_CP011125.1\|WP_053236289.1\|7370604_7371531_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237019
NZ_CP011125.1\|WP_053236290.1\|7371539_7372766_+\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NZ_CP011125.1\|WP_053236293.1\|7374850_7376308_-\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP011125.1\|WP_053236297.1\|7378182_7379493_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238119
NZ_CP011125.1\|WP_053236306.1\|7389371_7389815_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236302.1\|7385283_7385745_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236307.1\|7389814_7391065_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP011125.1\|WP_053236299.1\|7380835_7382035_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238119
NZ_CP011125.1\|WP_053236291.1\|7372805_7373771_-\|NADPH:quinone-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|176203
NZ_CP011125.1\|WP_053236301.1\|7383982_7384672_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274710
NZ_CP011125.1\|WP_053236309.1\|7392175_7394002_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NZ_CP011125.1\|WP_053236303.1\|7385741_7386845_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP011125.1\|WP_083457994.1\|7377064_7378102_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382
NZ_CP011125.1\|WP_157069601.1\|7373908_7374847_+\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197318

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_083458000.1\|7388654_7389323_-\|metallophosphoesterase-family-protein	gnl\|CDD\|378975	pfam12850, Metallophos_2, Calcineurin-like phosphoesterase superfamily domain. Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	6.27145e-10
NZ_CP011125.1\|WP_053236310.1\|7394148_7395930_-\|DnaJ-domain-containing-protein	gnl\|CDD\|365959	pfam00226, DnaJ, DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.	6.44874e-14
NZ_CP011125.1\|WP_053236294.1\|7376420_7377068_+\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	0.000247687
NZ_CP011125.1\|WP_157069602.1\|7379492_7380761_-\|hypothetical-protein	gnl\|CDD\|366051	pfam00362, Integrin_beta, Integrin beta chain VWA domain. Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.	8.63381e-08
NZ_CP011125.1\|WP_053236304.1\|7386919_7388653_+\|tryptophan-7-halogenase	gnl\|CDD\|380163	NF033113, halo_ClmS, chloramphenicol-biosynthetic FADH2-dependent halogenase CmlS.	2.58462e-21
NZ_CP011125.1\|WP_053236289.1\|7370604_7371531_+\|hypothetical-protein	gnl\|CDD\|237019	PRK11907, PRK11907, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	4.87836e-05
NZ_CP011125.1\|WP_053236290.1\|7371539_7372766_+\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	5.82986e-20
NZ_CP011125.1\|WP_053236293.1\|7374850_7376308_-\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.05937e-119
NZ_CP011125.1\|WP_053236297.1\|7378182_7379493_-\|VWA-domain-containing-protein	gnl\|CDD\|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	0.000358733
NZ_CP011125.1\|WP_053236307.1\|7389814_7391065_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	2.11731e-92
NZ_CP011125.1\|WP_053236299.1\|7380835_7382035_-\|VWA-domain-containing-protein	gnl\|CDD\|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	0.000662702
NZ_CP011125.1\|WP_053236291.1\|7372805_7373771_-\|NADPH:quinone-oxidoreductase-family-protein	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	8.98191e-156
NZ_CP011125.1\|WP_053236301.1\|7383982_7384672_-\|hypothetical-protein	gnl\|CDD\|274710	TIGR03664, purine_and_other_phosphorylases_family_1_protein, futalosine hydrolase. This enzyme catalyzes the conversion of futalosine to de-hypoxanthine futalosine in a pathway for the biosynthesis of menaquinone distinct from the pathway observed in E. coli.	1.14327e-11
NZ_CP011125.1\|WP_053236309.1\|7392175_7394002_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP011125.1\|WP_053236303.1\|7385741_7386845_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.16168e-25
NZ_CP011125.1\|WP_083457994.1\|7377064_7378102_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	1.62079e-24
NZ_CP011125.1\|WP_157069601.1\|7373908_7374847_+\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197318	cd09084, EEP-2, Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps, proteins.	8.29065e-27

>NZ_CP011125.1|WP_053236299.1|7380835_7382035_-|VWA-domain-containing-protein
MDAGPDAQIPCIEIPLDGGLIEIPLETEVQLGRADVVLAIDTTASMGQEIGEIRRTLRDQIVPGIRRAIPDANLGVTTYADFPEGGCGSAGDNDLPFRLVLPVTEDVGRVQSAVDSVRLNNGADTPESQVEALYQIATGEGVGRYVPASFGCPMGGFGYPCFRTDALPVVLLFSDAPFHNGPGGGSPYSDSMACPAVATVAHDYDDAVQALQRNEIRVIGLYSGPPRDRGLPDMRQLALDTNALGDGDEPLVFDIGENGERLSTSVIDAITTLAEVIELDIDTVLMDVDRTDAVDPRDFVEAVVPLRAEPMEGVREIDVPAGAFLGVRTGTTVVFGMTLRNDAVAPGAGPQRFLLEVVFRGDGRTRIGSVIIEIVVPGEDGTGCEEMTGTVLEIRGPSD
>NZ_CP011125.1|WP_157069602.1|7379492_7380761_-|hypothetical-protein
MTFPASIWRFGSLALIAGLVSCGARTGLDAPDAQIDAGMDAGPPPPPPPLCVDVPVDDPRVRVDLEIPASLRVVDVMFLIDSTASMQDEIDSVRERLRDRVVPGVRELIPDAAFGVALFGEFPVAPHALAGDDVGPFLLRTPITTDVVRIETALARTPVWGNLDDPEAAIEGLFQVATGAGLEPFIEASVGCPSGGVGGACFRDDAFRIVMLVTDAPMHNGPPDVSPVSNYERVRPAPHTYLETVEATRALDLFVIGLAASDAGRPSAFQHLVALARDTESVDGAGDPIVFDIGGRGDRIGAGIVDAVRRVAEEVPLDVDATVEDRPGDALDALDVVRAIHARSADPASGIAGMDGSRFLGVRPGTRLTFELEIDASELPPSPARREFAARVIFRESGRSRIEVRDIVIVVPGDDGLGCEDE
>NZ_CP011125.1|WP_053236297.1|7378182_7379493_-|VWA-domain-containing-protein
MRPDRRVVGVVAALALLGCGSKTGLFAPDAEAPFDASIDGPLDAFVPPDRFVPPDAFVPPDVCVELPPMEPPRSVDVSFVSRVLSAEVYFLVDVTGSMGEEIGEIRARLRDTIIPGIAGQIPDVRFSVARYADFPVDPYGSDGRTSGMPADDLYRLEQRSTTDIDAVQRALDRLERQGGGDLPEATVEALWVTATSDAPMRLVPARSCPAGTVGYPCFEREGSRIFLLFTDAPTHNGPGGSDRYAPVLGFRNHTYEETVMELRTIGAKVLGLYSGDGTDIGLPQLQNLARDTGAVRPDGTPIVFDIGTNGASLGSDVVEAVRTLVEEVPIDVDALTEDWPGDAADATEFVTEIVAASADPASGATRLPDRFVDVRPGTRVTFSIMLANERFVRMEEPQVFRMIVVLRGDGVTRLSETIVDIVVPAIDGDGCDELGR
>NZ_CP011125.1|WP_083457994.1|7377064_7378102_+|methyltransferase-domain-containing-protein
MTDDRGTRRPTYPGHPPIPSPARRPSSQPELPATSEIELVSDEPTQRRPPSTPQMPAVRPRSEPPPSPRGMRVGPSTTPQEAAIYDSVVVPRWSSMFGRAIVARIPQGARLTVLDVGCGTGHPAFDVMRRLGEGGRVIAIDRDPALVDLARRRALDDAGKRIFFKIEPLEHLSFGDEVFDIAVGNLVMGSVDDEGASLSEIRRVLAPGGRALLTRPLASTFEEVLDMFREIAVRRDHAALARRIEQLALRHPTPSAWRAQLAAAGLDDVHVDVEEVRLPFRNAREIFTDPMVRLVAMPEWRWLCGMQPGDESMLEQVEKALDTYFAGGPISLTVHVGLADARKPG
>NZ_CP011125.1|WP_053236294.1|7376420_7377068_+|HEAT-repeat-domain-containing-protein
MDRAREHLNALFEADRALRAAEDAFLESAEEKQIAHTLSSAVREALSLEDRDEQEMRLMRLADLCAQVQGPETVDALLAILDHDEPAVRNEAGECLLDVAYERFKEVATGIERLLGRGHSGHSMEELPFVLCEIRDPDPLPLVSRFLAHPRGEVVAAAIEALAAYGDPGAIRHLEKLTEDPREVTLPELEDATATIGDLAADAIAELEGDPGDGA
>NZ_CP011125.1|WP_053236293.1|7374850_7376308_-|sigma-54-interacting-transcriptional-regulator
MESGEQGGPGAGEGTFRGTQIRDDGTGPVLLEHRQKVVVVAGPDRGLEAEITGNSLAIGTAPTNDLVLSDDTVSRRHCMVSVQRDRYVVRDLESTNGTIVDGTPVLEAFLAPGARIRLGDTEILFQPKKKWERIEQQSGDRFGQLWGRSEAMKPVFALLAKLAPTDLSCILVGETGTGKELAARAIHEASRRAQKPFVVVDCGAISDNLIESELFGHERGAFTGADRQRIGAFEAAHGGTVFLDEIGELPIDLQPKLLRVLERREIKRLGSTRLLEVDVRVVAATHRDLPGMVRQGQFREDLYYRLAEVVVSLPALRERRGDVGLLAQRILDEYAEPGARPPQLDGSAIEELERRNWPGNVRELRNVLRRSMMMTSGPMLRAADLRLGAGPGGTSSRPPPPSPVDLTGEEATSPSIDVADDLPIKDARERWVAPMEREYLIRVLKRCGGDLDRAAADAGVHRKSFERLLRQHGIKAGEVLDTEDE
>NZ_CP011125.1|WP_157069601.1|7373908_7374847_+|endonuclease/exonuclease/phosphatase-family-protein
MLASLDRIALALTTPIAVLALLRIAPGLSGHPFDALEAYSGWALASAWVALGYAITRRRPALAMLAAPGALVHAGLIAQLVVAPSARADDDGLVLRVATANLYAGNPRPDALASELAALDVDVLALEELTPRWREVLGEHGVLARFPHRVIDDRDDCFGIALLSRVPMDATIEDLAGVPMIDARLTTSAGPLRVLAVHTIPPLGPDAADWNAQIALLARLASSSREPTIVTGDLNASPFGRGYRALIDAGLRGAHESAGRGLATTWPNGARLLPPMRLDHVLVSRGIGVREVREGRGEGSDHRPVIATLTVR
>NZ_CP011125.1|WP_053236291.1|7372805_7373771_-|NADPH:quinone-oxidoreductase-family-protein
MRAVLCESLGPVSSSLAVREIDAPRASGGQLVIDVKAAPVNFPDLLMVQGLYQMRPPLPFSPGGEIAGVVREVGPGVLGFAPGQRVMAFCGFGGFAERIVLAPAQCFAMPDEMPFEVGASLFLTYCTAHHALVDRGRVTRGETVLVLGAAGGVGVAAIQIAKALGARVIATASSEEKRQFCLSLGADQAIDPAADLKGTLKSLGGVDVVFDPVGGDLSEPALRALRPRGRFLVIGFASGTIPKLPLNLALLKECDVVGVQWGAFALREPDKQRAIVEDLIRMWRAGAVKPPIHRTYSLDETAQALDDLAQRRVMGKVVVTP
>NZ_CP011125.1|WP_053236290.1|7371539_7372766_+|PQQ-dependent-sugar-dehydrogenase
MRTRSLLTLSLALALTACGGDDDGPVGPVDPWMEFTPLQLPEGTMPLVGAAVVPGTDDEMILLEILGTVRHVRIEEDTVTELGSFTITLEDGCSLLSTAFDPDYETNHFLYVGQCTTVTGSEIVRYTFAPPDYESVVASAQRIYFVDEPMATRAWHQVGSIGFFDDGSMWALFGEQLRSANAQDVTNDLGKILRIVPSRDPAMGGSTPSPLNPFASGGGDESPNVWTWGVRSPFRGALDASGNLWVADVGENTWEEINVVTGPGQNLGWPVHEGLCRELDCDDFVQPIVSWSHTDDHRFVLEDEETENTTKRNAYVGLEYQPRNADQYGGRLTGRMIYGDMCAGWVRSVQRGSDGRAVADRFDGHRPYISQWIQGGDDMLYVTTLGLCDDPGAGPLEPAGLWRVSVAE
>NZ_CP011125.1|WP_053236289.1|7370604_7371531_+|hypothetical-protein
MVCRWFPSFFLFLSLIVASSSPASAQDEPVATEPTTEPTRVEATSAPETTTPETTTSDTTLAPAERTPVDANAPAVVTVAPPLPRLVRPHAFEGEAIIDTFWGFHVHGRGAIALHEMVDFTVHATLYTSPRLGGASSRTVDVLWVETGIGARAVLLDGALWAGGEIGLMHGALLSDSSEAIPLDGIAVRPYVDARVPLIDHVVGIDGLAQFTVFAPLRQGSGETRTLFHTIARVGAYLFDIVALGPYWEHLFVETAGGNLHPATWLGGYVEARLDFGLVVGAAAGVDLTPDEGLDDGEFYRAWLGWRL
>NZ_CP011125.1|WP_053236301.1|7383982_7384672_-|hypothetical-protein
MSSGQQRGADVLLVASHAPDLAGMRPYLGERLDGVIRNVRVRAKIVGMGMATAAAAAARGILAVQPRAVLMIGTCGVYPNLAQYRPHDVLVPSRAQLVDHAVLAVRASFPDPMQTVVETHGLMSSALRACHPRGHLAAVASPLAQTTDDTLAAAIAPATGCEAENLELFAVAMACRAADVPFVAALGISNIAGSTGRHDWSQFQRDAVSSAASAIAAWMHNGAQGLPHS
>NZ_CP011125.1|WP_053236302.1|7385283_7385745_+|hypothetical-protein
MSPNLLKPPVRVRPGALLRPREGVALGPRAEEELFRVAEVLTEGRLDQSAFFGSALITIDLEKVAPQLRGPEGEAERRRLFDVVTGSVRVRLRAMRLALADVARRHPDKRLGTATTETRFRLDGSLLLLDVDLEVPVDLSSLQRKSTGRDSVR
>NZ_CP011125.1|WP_053236303.1|7385741_7386845_+|tetratricopeptide-repeat-protein
MSQGDPVGGKIIHVQFGPGGGRRAVPATTVPTPPKSASTAVVPPPAEPIAAPAPDEETLAVDVAAQEAELEKQARRRDPTGDLYGRAEVARLFGIPESKLRYWDRTGFLSPSGVVGARRLYTFQDLIGVRTAKTLLERGVPLRRVRKTVEALRTTLPDVVRPLSELRVLTDGASVIVRDEKSSFEPRTGQVVMDFEVRELRDDVVRVLRPDALDPARRRAAYEAYLEGCRLDEDEATLDRAEACYRRAITLDPALANALTNLGNLRFRRGDGKEARGLYERAIELDPEQPEAWYNLGFLAFERGDLEDAVRLFDRAVSSDPSFADAHFNLAMALEEIGRTREARVHWETYLRLDPSGPWAEIAKRHL
>NZ_CP011125.1|WP_053236304.1|7386919_7388653_+|tryptophan-7-halogenase
MDGKTFDVAILGTGIAGSILGAILAKNGVRTLLVEQGSHPRFAIGESTVPETTFLFRLLGMRYGVPEISQLSTYNRVRRTVGTTSGVKRNFSFVFHRDGEPQRAHESSQLPTLSPPMGPDVHLFRQDVDAYLLGVAAARGAVVRQRTDVTSLDFGASGVELKCRDGSAFRASYVVDAGGVQAPVAKLFGLREQPTTMRTHSRSIFTHFHGVTPFDACIGPREGHGLPSPLSQGTLHHLFHGGWMWVIPFDNHPSSTNRLTSVGLNLDPRVHPPTGLPAEEEFRRFVARYPALAKQFENAHPIREWVSTDRLQFSSTRVVGDRYCLMPHAFAFVDPLFSSGLGISMGAINMLAWRLIEAKKDGDYSTERFMPIDARVKRNFAHVDRLVSRSYVAFSDFELWNAWYKIWALGTIFGGTGTLEAIGEVLTHGAGTRFEPYELAPFGGLQGSDLPEYMALFDRAAAEIDAYAEKRVSASQAAERIFAVIEESRLWPAPWGSPRARHPGVFTLPKVGPLIQWMQRDAPQGIRDAYARRFVLRHVVKMAADEWASELGYAGKLVTTLGRDFVTGYNRDWDRAD
>NZ_CP011125.1|WP_083458000.1|7388654_7389323_-|metallophosphoesterase-family-protein
MASSRTAPASAPMAFLADIHGNLAALDAVLQDIRRRDVGIVYVAGDLLFGGDDPLAVWKRLVEVKAKCVRGLSDAALATLDPTRMSPADEVQRERMERFLRTRTAVGELVLKYLERLPDSMRIPLVDGREIVVVHGSPADPTTELSHDMSDEEMMALIADDPADIVACGGSHVPFQRDVDEVRVIGLGSVGESPEGGIAHYTVVTPRLEGTLVEQTWIRYAA
>NZ_CP011125.1|WP_053236306.1|7389371_7389815_-|hypothetical-protein
MQAREAALAEALAPVGAARVLWIGVSPIDALDAARGANRASLDALPSDARFDAVVLGPTASGLVDASAAVRACVREGGVIAMVLPVERAGLRAFTQRALGAFDATRRARPLEEACGALLSAGVAPVKVIDVKGALGEAVVHGVVRAT
>NZ_CP011125.1|WP_053236307.1|7389814_7391065_-|HlyC/CorC-family-transporter
MSALTAAMYALPEELLMAVRDEEGPDAPTANRVLRERAAIRARLLTGRVMSVAALAAATAHLVMGQMPLWAGVLVVAAASLGYAVLAEVAQTFARARARVLGLRLLRWSRPLEMMFAPLAWPIQIVASTTERLLPQRDEAVDEDLAAREVEHMIERREEEGVIPEEFAQLLLRVLEFKDTVAREVMVPRTRMVAIDVSTPIDDVVARVVEEGHSRYPVYRERVDRIEGILHAKDLFRAMREKKGRVNLLSIVRKPALFVAESQKIGHVLREMQSKRQHLALVVDEFGGTAGVVTLEDILEEIVGEIQDEHDAEESLVMEIGPNTFLADARVSIHELGELLDTELGEAAENAEVEVDSLGGLVVGLAGKVPEPGESVTLDGLDLIVREADEKHVTRVEIRRKTTAPPSSASPAEGAV
>NZ_CP011125.1|WP_053236308.1|7391286_7392087_-|hypothetical-protein
MTLEFAGPPLALPDDPAPQERDSDRPEPLHLDTAELDTAELDTAQRAPSAKARATIDPEGFLDPELVTEDRGTEQALQLDLGELEASPRADDGWGRLREGNAPARPRSVTPPPMTRDDALELVTRRSRPPSTPGLDLAGEMADRYALGDYTGALRVAELLLGRDPDDVRAQRCAESSRERLLALYTARLGSVSGVASSEVGARVPRIAVPEHEIRWLGLDHRQGFLLSRLDGSVTVDDLVDVSGMSRLEVLRTLVELVESGAVGVQ
>NZ_CP011125.1|WP_053236309.1|7392175_7394002_-|molecular-chaperone-DnaK
MEKVIGIDLGTFNSCVAVVEGGTPVVIANRGGYKVTPSMVAITEAGKRLVGHIAKRQAVTNAENSVYAAKRLIGRKFHSPQVQAAIGNVPYRIVEGPHNDPRIQLRDKVYSVPEISAMILQEMKMIAEDYLGHEVHKAVVTVPAYFNDGQRQATRDAGAIAGLDVIRIINEPTAAALAYGFGKNIDRRVAVYDLGGGTFDISVMEISSAGVFKVVSTAGDTFLGGEDFDQRIIDWLVQGFREEHDIDLRQDRMALQRLKDAAEKAKCELSSVVETEVNLPFIISSARSEALHLQRLLTRSQLEELTDDLVQRTIEICDMTLKEAGLEKDEIEDVILVGGMTRMPKVQAAVADYFEREPCKGVHPDEVVALGAAIQGAALVDDEQDMVLLDVTPHTLGIMVHGGLFEELIPQNSTVPTSRSKIFTTVRDNQTAVKILVMQGESKRADENELLGEFILTGLRRASAGAVEIEVTFEINADGIVSVHAKDLETGKAQSITVTATSGLTKDEIDQMVDDAQTYAVARRDDEELERAKQEAETLIAEIQRLFPKVEEVVAGSDFGRDAIDKARIVVEKARSLMQAGDTRGLKEQIEALNRTQRMFKGVVGKIG
>NZ_CP011125.1|WP_053236310.1|7394148_7395930_-|DnaJ-domain-containing-protein
MDLRSLPLTPTEGFILSRIDGVATIDDLSDLTNLDVSDVVIAIGRLIELGAVEWADGTISLPRASNRPPTPSQGVHRRAIPSPRAFERPNVTESEPPSATREPTRVKVPPPARVPVPSSTSPTSPPPPSSATPSDTIDPRRLEGRVDASRPPTARPGNVARVNVRDRPPSNPTVPTADATARRPTPPAMPATQPPPASPPASEPAAVVPSSAGSLPAEIDLPPERRKRIDELYPVLELLDHYEVLGLRPNAELKDIRATYFELSKVFHPDTAFRKSLGPYKAKMEAIFTRLTEAYEVLGKKKPRAEYDAYLALQGDTRAVEDAMRAPAKPAASPSPPAPSPPPEPPPPPSPAPTESPARALSDEGRRRARELLERRLQGARPATTTTSSGAIPSPTSSAPRARDEVLRDLASSLKSTASLTGGIDRISRHQRDAQRLEAEGDLAGASRELRMATALAPQRDDLRLEHERVSRLLAAQLADKYEQAAQYEEKHRKWAAAAISWSKVVDGRPDDVAALLRAALALVEAKGDLHQAQRFAQRACELRPDDVAARRTLGRVYLAAGLQLNARRELERAALLDPTDQIVKNLLGELKG

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Crispr_ID: NZ_CP011125_29

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_29

8008226-8008333

Orphan

Consensus_repeat	Method
CTACGGGAGTGCTCGTCCCGCGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_29

>merge|NZ_CP011125|29|8008226-8008333|CRISPRCasFinder
CTACGGGAGTGCTCGTCCCGCGGGTCCCGCACGGGAGCGCGCGAAGCGCGCGGACGGAAGGGACCAGCGGGCGAGCCGATGTCACTACGGGAGTGCTCGTCCCGCGGG

>NZ_CP011125|29|24|8008226-8008333|CRISPRCasFinder
CTACGGGAGTGCTCGTCCCGCGGG	TCCCGCACGGGAGCGCGCGAAGCGCGCGGACGGAAGGGACCAGCGGGCGAGCCGATGTCA
CTACGGGAGTGCTCGTCCCGCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053236771.1\|8006279_8006534_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236766.1\|7999040_7999703_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236768.1\|8001077_8001701_-\|recombination-associated-protein-RdgC	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236776.1\|8010721_8011486_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369378
NZ_CP011125.1\|WP_053236772.1\|8006622_8007528_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236770.1\|8004565_8006209_-\|alkaline-phosphatase-D-family-protein	unknown	unknown	gnl\|CDD\|378184
NZ_CP011125.1\|WP_157069700.1\|7999741_8000965_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276965
NZ_CP011125.1\|WP_053236765.1\|7997262_7997955_-\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|238449
NZ_CP011125.1\|WP_169791644.1\|8011525_8012299_-\|DUF1517-domain-containing-protein	unknown	unknown	gnl\|CDD\|226808
NZ_CP011125.1\|WP_157069702.1\|8007652_8008222_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069706.1\|8014739_8014904_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069705.1\|8013495_8014722_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_083458124.1\|8014900_8016076_-\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NZ_CP011125.1\|WP_157069707.1\|8016129_8017110_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236775.1\|8010445_8010655_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236774.1\|8008343_8009696_-\|outer-membrane-beta-barrel-protein	unknown	unknown	gnl\|CDD\|369446
NZ_CP011125.1\|WP_053239044.1\|7998068_7999028_+\|transcriptional-activator-NhaR	unknown	unknown	gnl\|CDD\|176120
NZ_CP011125.1\|WP_157069704.1\|8012387_8013479_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069701.1\|8001800_8004419_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274612
NZ_CP011125.1\|WP_157069703.1\|8010009_8010204_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053239044.1\|7998068_7999028_+\|transcriptional-activator-NhaR	gnl\|CDD\|176120	cd08429, PBP2_NhaR, The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold. NhaR is a positive regulator of the LysR family and is known to be an activator of the nhaA gene encoding a Na(+)/H(+) antiporter. In Escherichia coli, NhaA is the vital antiporter that protects against high sodium stress, and it is essential for growth in high sodium levels, while NhaB becomes essential only if NhaA is not available. The nhaA gene of nhaAR operon is induced by monovalent cations. The nhaR of the operon activates nhaAR, as well as the osmC transcription which is induced at elevated osmolarity. OsmC is transcribed from the two overlapping promoters (osmCp1 and osmP2) and that NhaR is shown to activate only the expression of osmCp1. NhaR also activates the transcription of the pgaABCD operon which is required for production of the biofilm adhesion, poly-beta-1,6-N-acetyl-d-glucosamine (PGA) .Thus, it is suggested that NhaR has an extended role in promoting bacterial survival. This substrate-binding domain has significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.97124e-89
NZ_CP011125.1\|WP_083458124.1\|8014900_8016076_-\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	3.10221e-39
NZ_CP011125.1\|WP_053236774.1\|8008343_8009696_-\|outer-membrane-beta-barrel-protein	gnl\|CDD\|369446	pfam07642, BBP2, Putative beta-barrel porin-2, OmpL-like. bbp2. BBP2 is a family of putative porin proteins that are likely to be outer membrane beta barrel proteins porins.	6.27441e-45
NZ_CP011125.1\|WP_157069701.1\|8001800_8004419_-\|hypothetical-protein	gnl\|CDD\|274612	TIGR03502, lipase_Pla1_cef, extracellular lipase, Pla-1/cef family. Members of this protein family are bacterial lipoproteins largely from the Gammaproteobacteria. Characterized members are expressed extracellularly and have esterase activity. Members include the lipase Pla-1 from Aeromonas hydrophila (AF092033) and CHO cell elongation factor (cef) from Vibrio hollisae.	7.45138e-12
NZ_CP011125.1\|WP_053236765.1\|7997262_7997955_-\|carbonic-anhydrase	gnl\|CDD\|238449	cd00884, beta_CA_cladeB, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	2.7398e-85
NZ_CP011125.1\|WP_053236770.1\|8004565_8006209_-\|alkaline-phosphatase-D-family-protein	gnl\|CDD\|378184	pfam09423, PhoD, PhoD-like phosphatase.	7.9894e-122
NZ_CP011125.1\|WP_157069700.1\|7999741_8000965_-\|hypothetical-protein	gnl\|CDD\|276965	sd00038, Kelch, Kelch repeat. Kelch repeats are 44 to 56 amino acids in length and form a four-stranded beta-sheet corresponding to a single blade of five to seven bladed beta propellers. The Kelch superfamily is a large evolutionary conserved protein family whose members are present throughout the cell and extracellularly, and have diverse activities. Kelch repeats are often in combination with other domains, like BTB and BACK or F-box domains.	8.21488e-26
NZ_CP011125.1\|WP_169791644.1\|8011525_8012299_-\|DUF1517-domain-containing-protein	gnl\|CDD\|226808	COG4371, COG4371, Predicted membrane protein [Function unknown].	7.23998e-10
NZ_CP011125.1\|WP_053236776.1\|8010721_8011486_-\|hypothetical-protein	gnl\|CDD\|369378	pfam07466, DUF1517, Protein of unknown function (DUF1517). This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.	0.000105444

>NZ_CP011125.1|WP_157069702.1|8007652_8008222_+|hypothetical-protein
MSTHHVGLGFPRPASLCFWLVSNLVPRCFGWTLVALVASTSGGCFTHSPIDDSGRQRARATERAAIACDGLAPELVERTLADAPHLVLHAEAITAFGGRPRRLQTLGVRIRVDNDLGLDARLAERVLSCQSARYAARGESLTARDPLAVAGLVMRVEKADDHIELVLRARDPRDAEEAVRRASALLADR
>NZ_CP011125.1|WP_053236772.1|8006622_8007528_+|hypothetical-protein
MGSGTTTGRAQKSTGKRRAANGAKSANGHAVHADGEGAKTNGARHKRSARDVDVETASSEAPVERARESERLVPVKARPSRSEREFAEQRAQEIDDVCAAWAAIVAERMAADQQFAESYEQFQKRPRDLRGLFLWDQLHAAESHVAMVNAVIAKHLEGRRADPFAILTDLRAAQRKLAVVYAVNAFLAVLNQMSPSKPKWLTVEALDPRMAVLALAHQTLEYALEAARIEAPSDLTEQILAAAQDESVWTGARDASDRTLAACAATAAFFRTLGAQDLATIDEIVTLYETHARGRDVRAAF
>NZ_CP011125.1|WP_053236771.1|8006279_8006534_-|hypothetical-protein
MRTKLGLAIALVASLVASVARADAVPACGPFEHREGRPHESECRFGPAWLCSVPGAVTSHDEAIAPSLVVLAGLVVMVRRRSRR
>NZ_CP011125.1|WP_053236770.1|8004565_8006209_-|alkaline-phosphatase-D-family-protein
MDSSSKGPGFSRRRALKSAGVLGAATMIGCESTDVPLVDASMQMGGDAAMPDTGPRGRDAGPAPMGAFQHGVASGDPLADAVILWTRVTTESTSAIALAWEMSRDASFATIDASGEASADPARDFTAKVDATGLMPATTYYYRFRVVDGGETSPVGRTRTAPASDAEIARLRFAVCSCSNYAFGYFHGYRNIAQRADLDAVLHLGDYIYEYGTGEYGTFRDCDPPGEIVTLDDYRRRYRQYRTDPDLQEAHRQHPFVNVWDDHESADNAWRDGANNHDEAEGAWADRKAAAQQAFDEWLPIRTASEGPSRIWRALRYGALAELVMLDTRIDGRSEQGAGEPGARPLISSEQEAFLIERLTTSDAQWKVIGQQVMFSPLPLLANDDQWDGYPASRTRVLDAIRGDGERDPVRDVVVLTGDIHTAWACEVVEDPSASPLPPASAVEFVAPGISSPPISPPGGPIERALMRSLAARAPHIKYADISHRGYFVLDLSPARVHATFVQIADVEAPYDTSELEVTAWEAASGTSRLVEVEPTSPPDGAPPLAP
>NZ_CP011125.1|WP_157069701.1|8001800_8004419_-|hypothetical-protein
MLHVLLALVAGCGLPLDTDQRVPTFPIFDPGTGEIPMPNDALRDDEEGHLDLPIDDDDPELSETERAFRAWMNTRDGWSTTMAATVRFSAVVDDRSIDPDTVQVWDWLPTPQRVSDLEVRLEEGDRRLTILPPRTGWEPGHRYVIVVRGGELGVRDTQGFGVEPDAIFYFLRRDQVLNTIGHNRAFPGATRAERLDAGSRLEDLRLELAPFFEFFEDPARPTQSEIPRDEVAALWSFTVTQDPELAMDRDSQRVPLPFDLLVDPETGLVSLEEAEWDSELEANAKRQANELDGFGVSPNLLFEMTEAVDPTTVAGNVHVFELDDTPRELPVSVKVMGDDGEEACRQTPTPADCIHLVVVVDDSALPLQGHTTYAIVVDRGVRSAEGEAVEPMPLGWFMRSEHPIAVRGASQIGSLTDELASRVEVTRARIDEFLDGYGRENIVTAWPFTTMDAVPGIRESARASIDLELDAEPTVRERLTPAQALEALSPGVEGAAIRAVYLTRSIGVREYVIGTIPSPYFLDPISRRWREDGQHPMQPVRFYMAVPNDLPEDEPAPVVIFGHAIVTDARFLMGIAGELAQRGFVAIGIDFPFHGERIACIDASLVAIPNFFPEVFRNLTGLDDDILRFPPCASGSDATCSTDGRCLTSSGEPDEFNQFPLVAVQMASGAAFLDTHDLPYINDHFRQALVDLSSLLRSIQTADWEGATGVRLDPERIHYVGQSLGAIIGSVWVSVTPEIDRAVLNVPGSDMVDLFVESTYFSPQIDEYFTSIDVPRPSFEEERLLDVARWLIDSVDPHSVAHLYAQEDRQVLIQMSRGDIIIPNRTTEVLQRVSGRPLRSYPTPLHADLIIPALGDAMLRDMGAFLSGEIEE
>NZ_CP011125.1|WP_053236768.1|8001077_8001701_-|recombination-associated-protein-RdgC
MSALSGSLSYARFFAPRSLPRGFLDKSHEKILHHAMRPLRPEEPDAERSGWCVMGDALDVDLPSERIYLDGFLNLGFRTDRWAIPGPLLKTRVREAETKYREKSGRDKLSRRERAEIKEVVTRELRKRLVPTTRVIDLTWSLEEGVVRFFSHTERNALAMLELFQKTFGIELVAESPYTLAQRLELGEDETQAWAELEMTVLAPRGR
>NZ_CP011125.1|WP_157069700.1|7999741_8000965_-|hypothetical-protein
MRTLAPFLVLSFVLSACGGSSDDPPIVLPDAALPDASAFDAGAGDVDAGPRVALAIEPTGSIHVARLGHTATRLPSGRVLFVGGEDLGRVPTASIEEYDPETGAFEEVAMLPAARVNHTATLLADGRVLVAGGGASASNGVPAGTAVTESVVIYDPSTHDVIDAAAMAHARGHHGAILLSDGRVLVAGGAATPASGGGFAPVASIEIFDPEEGTWSEGGALAAPRAMLSLVEHDGAVLVIGGFAPTGAPHEIERIDTTTGAVSPGGRLAGPGRFFHATLRTRDDDVLVVGGLAPPVFLDVVEALGSSDEAFRALPELPSPRNSIALVETSAAVLAIGGFFFSPSTGGQSIEDVLALDPEGERFEVVGSIPLGRSGHTATVLASGDVLVAGGYTSVGMTDVALLVRAE
>NZ_CP011125.1|WP_053236766.1|7999040_7999703_-|hypothetical-protein
MQLADLIEKRRFVGRELLLWLWMESELFDGTLSTREHGSFGLWIEKKLVLSADAESTRITAALPGLGREAKEALLRGQLPESAGIRISRGDDDTSLVLTGESFAVRGLKLQTELGGEGEAVTGDLVDEMAGRTRGTPKKKKGADEDEADDTPFYERMKMTREIEEVLAALYREFLALRLSARWAGVVVPTLQRWAEGERVDADAYRAARDGKSAKKRARA
>NZ_CP011125.1|WP_053239044.1|7998068_7999028_+|transcriptional-activator-NhaR
MEWLNYHHLLYFWTVAHEGGLLPAARKLRVTHSTVGAQVHALEESLGEKLLVREGRRLVPTDVGRLVLRYADEIFGLGRELVDTVRGRPTGQALRLDVGVVDVIPKLVARRLLRPAHELDQPVRIVCREDHLERLIGELALHSLDAIISDSPPPPSANVKVFGHPLGECGVTLFAAPALAKKLARGFPRSLDGAPMVVPTEGTVLRRSLDRWLAAISVRPTIVAEIEDSALLKAFGQDGAGVFPAPSVVRDEVVRQYGVRALGEAPGVVERFYVITAERRFQHPALVAITARARAELDASPKTARRRPGASARDHTGSR
>NZ_CP011125.1|WP_053236765.1|7997262_7997955_-|carbonic-anhydrase
MKKLVHGVHRFHSEVFASQRDLFLRLGGGQSPQALFVTCSDSRIDPNLLTQTQPGELFILRNAGNIVPAWGTHGAEAATIEFAIAGLGIEHIVVCGHSHCGAMKALITPGSVDRMPAMREWLTHAAATGQVVDECYADRDPEERLNVAIQENVLAQLTNLRTHPAVAARLATGKLHLHAWVYKITSGEVFAYDQDAGQFRVLGGEAPAMDQPRRSLDGALLADARDGGSR
>NZ_CP011125.1|WP_053236774.1|8008343_8009696_-|outer-membrane-beta-barrel-protein
MNELVSRTSKRAAGAALAILVSLTLVPRANAQDTATSEPSAEPAPGAVVETPATTEAPAEAAVAPAEEPVVTAEPVAMPEVVAEEEEVAATEPEAEASSWTDNLSFRVFADAYVAAHWTLPNGFEGNQSAIIGHRAYDIYGGPSLAWAGLDLRYAPDPLGAAIDLRFGTAVPRLLGAFSGLPEGLQFLKQAYVSWRPIENFQIDFGQFDTIYGAEVSESWLNPNYSRGSLYNVVQPFYHMGFRASYAVIPELTLTAIAVNGWNNVSDNNDGKSVGIQGALTVGDFSVALGYLTGPEQSDCNAIPGPDDPPIAGCVTDEDLGDHDGRFRHLVDLILRYSVGDLALVANGDVTIEDFGPAGYTTIAGGMIGAQYRFIPEFALALRGEVLYFEDTDESLTTGTFTIEVAPDPHLVFRLDNRLDVSSYDQFVDNSGQPSELVFSSILGVVAHSD
>NZ_CP011125.1|WP_157069703.1|8010009_8010204_-|hypothetical-protein
MTNSKGRIAAGIVAVVMACTALVGCGGRQQPPTTGTCHPGREWVPPAQDENGQWRDGYCRSTGG
>NZ_CP011125.1|WP_053236775.1|8010445_8010655_+|hypothetical-protein
MDDPSTEATIWLAALAAAVRRAQSASTQHERLAALEALDETKMRLEDALARVREELALGVEPPSDALLS
>NZ_CP011125.1|WP_053236776.1|8010721_8011486_-|hypothetical-protein
MRGKLLAVIALVAIASSCAVASAQRAGGSSGGGRSGGGARSSSGSHGRGRYFYAGRHGQTAYYYDAYSSTGSRVAGGDGPLWLGLFLIVGALVVSARPRTVRRDAAPDAQSPEWKNVDLGVVEVTVDRATRVEIERAIARRKTHRREPRRVRRLRAMVDALRAHRAAWRAVRVEDHRPMSSPIADGVFRRLATGARSGSVGDDREVLTIVVASRREIVDVHRSDEEAADRVLRAMAQLELREIVALEIAWREAR
>NZ_CP011125.1|WP_169791644.1|8011525_8012299_-|DUF1517-domain-containing-protein
MIFGALLSLSLLLVGAFAEAAIAEAQRTGGSFGGRRWSGGGRGRAPIGSSYRGTRYGGGGYYGPAPFVFFAPGGIGAGGLVTLVVIGGVVMLLARGARRATLRVPGPQSRAWDNVDLGVVQIGVDAETRRAIEETLAARRVPLRVREHGATWLREVIHELRARRDAWLAVRVDDYRPMSPPMAAGSFRRVQEDAQHGAPLAEHDGELEVVTIAVASHREIVDVQRDDADAAERVMRALAQLDPDEIVALDVRWAAPA
>NZ_CP011125.1|WP_157069704.1|8012387_8013479_+|hypothetical-protein
MTTTRALVIVSLVAAGCGGAASAPTHDRGELACAPARACDETADAWPSTDAYRGWAPFDEREVPASIVEPVPPLPVCAVESGSQVLRWTRDARGLPASYEQVEHGEVQLRVRWEHDASGMLVRETVERELVPVHVQGDGDRGPTFVDGRPERVTTWQRDGATLREAIDEDGDGTIDREIVRTLDARGATRSETRVRCGGSTRAGSELRTWERDAQGRVIAERCDAEGARWSKRTIHGEHGPSRMAYERRDEFGARALEHQWTYDGAGRLVREGFDADGDGALDVWREHEITLDEHGRVAALRTVPHGDGRRAVEHRWAYDAEGRRVDHVIVEGASTSSVPRGYDARGRLATTLAATTLRYECE
>NZ_CP011125.1|WP_157069705.1|8013495_8014722_-|hypothetical-protein
MEIRIVLTALAIASLTACGSETPRDDTPDAGSPPDGGGAAPAYAVTTTVFDETTAATYVTVLGSLDAQQVDLSTAREFAGWSSVAAHDAVLFVGHGERPEVERYALGADGTLGDAEQTVSFAAHGLSSASLSFNTIVDATMAHMALEQTSRVLWDPTAMEIVGSVDTPEVAPERDGMAVTAANFQGRVVREDGVFQPYFWHDADWYAFHQQSQIAIYARDGSLDALLDVPCPALQIATEDEQGNLYFSGMVDTIAYDLVEEASTLERCVARIDAGEHAIAEGWPRRFEELTEGRPAGVFHYLADGIGILTVYHVENADPSSPTFLDDWYAANWGLWLVDLEAWSAEPIEAWPLGSSNIFFSRLEGRLFVHSVEADFSSTTIREISVDGTLTERLTVPGYAAYPLLRLR
>NZ_CP011125.1|WP_157069706.1|8014739_8014904_-|hypothetical-protein
MSARAGLVIAGVAIGQAAFGTIDTLQGDGTIPVSAIALAFLAISIVALAPWARA
>NZ_CP011125.1|WP_083458124.1|8014900_8016076_-|PepSY-domain-containing-protein
MGPSSRARMANRHGVERRALPARARPRGGVKRAFRVHGALGMTFGAALFVICASGALAAVSSDVDWLVHPALRAPALADGAPRASWGALHASARAHAPDARVIVLAAPLEPGFAAEAIVARPDDTLARIWLDPRDARVRGEGPYLTVQRFARDLHRSLFLGENVGVFVVALFGLALLGSTASGVLVVWRSRSRRLLRVAKERASKDLHRVGGLALVAFALLAGITGTWYGVERVAAWADVELTPAAPSIDEAGRARATSEPIADLDTLVALGRAAMPELEVRAIAMPTERRPVLSLLGETDALLARDQANQVFLDPGARVVLGVWRADAMPPIERWVHTVDALHFGSFGGLPTRALWSAMAIGTALLALSGAWIRARRSARSSIEAQGGAA
>NZ_CP011125.1|WP_157069707.1|8016129_8017110_+|hypothetical-protein
MCCSAGAQALAHRSARSAGSSSCDPEQPSALHAASTLGSAPSRGDSRVRGALTDSDRDAGIAPSRGGHRMTIPITVEDLIAIGERFPSEAIIAEIDRLLPIASADLAMLEAGGYSADLLDALRGYRATLTEETAGRRAQRAAKKSARSVEAEAIAEAKRVLRAAVVMAEAAITYRVPPTGEAPETTQRITRDLAAALESARGVVGHDSAKLRTRLTAVAAVLGSASIAPAESGRAARTAMIARVTAAIAALPALAEEKKAAQHEARSNTDALDEIDGRAYLNLRTLAKVGRAQWRLAGDKTRADAYQLTLDDRRPKRSGEPTPTPA

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Crispr_ID: NZ_CP011125_30

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_30

8277496-8277611

Orphan

Consensus_repeat	Method
GCGCGCGAAGCGCGCGGACGGTAGGAGCGGCGGGCGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_30

>merge|NZ_CP011125|30|8277496-8277611|CRISPRCasFinder
GCGCGCGAAGCGCGCGGACGGTAGGAGCGGCGGGCGAGCGTTTGCGGGAGTGCTCGTCCCGCCGATCCCGAACGGGAGCGCGCGAAGCGCGCGGACGGTAGGAGCGGCGGGACGAG

>NZ_CP011125|30|25|8277496-8277611|CRISPRCasFinder
GCGCGCGAAGCGCGCGGACGGTAGGAGCGGCGGGCGAGC	GTTTGCGGGAGTGCTCGTCCCGCCGATCCCGAACGGGA
GCGCGCGAAGCGCGCGGACGGTAGGAGCGGCGGGACGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053236990.1\|8271945_8272686_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP011125.1\|WP_053234869.1\|8287328_8288144_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|366760
NZ_CP011125.1\|WP_053239057.1\|8269905_8270760_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236600
NZ_CP011125.1\|WP_053236997.1\|8278729_8280805_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053237003.1\|8285176_8285842_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NZ_CP011125.1\|WP_053236998.1\|8280892_8281141_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237002.1\|8283704_8284838_-\|epoxide-hydrolase	unknown	unknown	gnl\|CDD\|377658
NZ_CP011125.1\|WP_053236994.1\|8275326_8276742_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|214500
NZ_CP011125.1\|WP_053236993.1\|8274874_8275330_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|334450
NZ_CP011125.1\|WP_053237000.1\|8282679_8282946_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053239058.1\|8270864_8271326_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP011125.1\|WP_053236999.1\|8281137_8281806_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236995.1\|8276977_8277457_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069745.1\|8269238_8269832_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053236989.1\|8271453_8271963_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235139
NZ_CP011125.1\|WP_053236991.1\|8272771_8273527_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368243
NZ_CP011125.1\|WP_053237001.1\|8282947_8283625_-\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|376576
NZ_CP011125.1\|WP_053236992.1\|8273599_8274844_+\|DUF697-domain-containing-protein	unknown	unknown	gnl\|CDD\|226125
NZ_CP011125.1\|WP_169791765.1\|8278001_8278730_+\|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase	unknown	unknown	gnl\|CDD\|274396
NZ_CP011125.1\|WP_053239059.1\|8281807_8282542_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153228

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053236990.1\|8271945_8272686_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	9.33846e-11
NZ_CP011125.1\|WP_053234869.1\|8287328_8288144_-\|ATP-binding-protein	gnl\|CDD\|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	4.23706e-42
NZ_CP011125.1\|WP_053236997.1\|8278729_8280805_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.39807e-85
NZ_CP011125.1\|WP_053237003.1\|8285176_8285842_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.02243e-13
NZ_CP011125.1\|WP_053237002.1\|8283704_8284838_-\|epoxide-hydrolase	gnl\|CDD\|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	6.09373e-47
NZ_CP011125.1\|WP_053236994.1\|8275326_8276742_+\|GAF-domain-containing-protein	gnl\|CDD\|214500	smart00065, GAF, Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.	3.26519e-13
NZ_CP011125.1\|WP_053236993.1\|8274874_8275330_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|334450	pfam01243, Putative_PNPOx, Pyridoxamine 5'-phosphate oxidase. Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as yeast YLR456W and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.	7.21493e-06
NZ_CP011125.1\|WP_053239058.1\|8270864_8271326_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.17672e-21
NZ_CP011125.1\|WP_053239059.1\|8281807_8282542_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|153228	cd03134, GATase1_PfpI_like, A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. This group includes proteins similar to PfpI from P. furiosus. and PH1704 from Pyrococcus horikoshii. These enzymes are ATP-independent intracellular proteases and may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For PH1704, it is believed that this Cys together with a different His in one monomer and Glu (from an adjacent monomer) forms a different catalytic triad from the typical GATase1domain. PfpI is homooligomeric. Protease activity is only found for oligomeric forms of PH1704.	4.93853e-71
NZ_CP011125.1\|WP_053239057.1\|8269905_8270760_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236600	PRK09636, PRK09636, RNA polymerase sigma factor SigJ; Provisional.	1.0095e-66
NZ_CP011125.1\|WP_053236989.1\|8271453_8271963_+\|hypothetical-protein	gnl\|CDD\|235139	PRK03612, PRK03612, polyamine aminopropyltransferase.	0.00731679
NZ_CP011125.1\|WP_053236991.1\|8272771_8273527_+\|hypothetical-protein	gnl\|CDD\|368243	pfam05019, Coq4, Coenzyme Q (ubiquinone) biosynthesis protein Coq4. Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway. The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).	2.58225e-40
NZ_CP011125.1\|WP_053236992.1\|8273599_8274844_+\|DUF697-domain-containing-protein	gnl\|CDD\|226125	COG3597, COG3597, Uncharacterized protein/domain associated with GTPases [Function unknown].	7.87708e-11
NZ_CP011125.1\|WP_169791765.1\|8278001_8278730_+\|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase	gnl\|CDD\|274396	TIGR03023, Sugar_transferase., Undecaprenyl-phosphate glucose phosphotransferase. This family of proteins encompasses the E. coli WcaJ protein involved in colanic acid biosynthesis, the Methylobacillus EpsB protein involved in methanolan biosynthesis, as well as the GumD protein involved in the biosynthesis of xanthan. All of these are closely related to the well-characterized WbaP (formerly RfbP) protein, which is the first enzyme in O-antigen biosynthesis in Salmonella typhimurium. The enzyme transfers galactose from UDP-galactose (NOTE: not glucose) to a polyprenyl carrier (utilizing the highly conserved C-terminal sugar transferase domain, pfam02397) a reaction which takes place at the cytoplasmic face of the inner membrane. The N-terminal hydrophobic domain is then believed to facilitate the "flippase" function of transferring the liposaccharide unit from the cytoplasmic face to the periplasmic face of the inner membrane. Most of these genes are found within large operons dedicated to the production of complex exopolysaccharides such as the enterobacterial O-antigen. Colanic acid biosynthesis utilizes a glucose-undecaprenyl carrier, knockout of EpsB abolishes incorporation of UDP-glucose into the lipid phase, and the C-terminal portion of GumD has been shown to be responsible for the glucosyl-1-transferase activity.	1.03666e-132
NZ_CP011125.1\|WP_053237001.1\|8282947_8283625_-\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|376576	pfam01618, MotA_ExbB, MotA/TolQ/ExbB proton channel family. This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels. MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller. ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.	7.74828e-16

>NZ_CP011125.1|WP_053236995.1|8276977_8277457_+|hypothetical-protein
MATKKNTKKVGKKSAKKVAKKRAKPAPIALTPAERSRKLRPRRDYRELIETFLRVWEENPSVRLTGLTRAQLRRALGLAIKAADKEDALRREADTKLRVLMDARLVAEDDLWRKLLDANALVRAQSRVDPRLAEAFAFLSDALRPESRERDDAEEPAAG
>NZ_CP011125.1|WP_053236994.1|8275326_8276742_+|GAF-domain-containing-protein
MKLAVPLERLSRCFQGIVPGAIATCDADGLPNVSYVSHVQVVDDRHVALSCQFFNKTRRNLDQSPLACVQIVDPLTLQAYQMRLRFLRSERDGALFESMSARLDAIASHTGMKGVFKLLSSDVFEVLEIEVLADFLTGAEPSITGHDEPMAIPGPASELRALQTVSARINRACDLEALLASTLAALEELFGFGHAMVLVPDGSGKRLVTIASHGYGDGGIGAEVAIGDGLVGTVAEERRVLAVAGIDAGLRYGRAIRDATRRAPSQANVRPEIPLPGLPDARSQLGLPLLVEDRLLGVLAIESRDPAAFEPWHEAFLQVLANQIASRMDHLAEHEDDEDDDESPSARRPDPDRIRISLPGGDRTRVFCFYKNDDAVFVDGEYLIRNVPGKILWKLLNAHARERRTEYSNRELRLDPWLGLPAIKDNLESRLILLRKRLEQKCPEVRIVPTRRGRFALELECAVELVERETA
>NZ_CP011125.1|WP_053236993.1|8274874_8275330_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MLSAELVDVLESGPSMLIATRDAQRMPECTRAVGVVVRGPARVTIFVPRAVGARAVANLAVEPRIALTFSRPHDHRTYQLKGTTTAVRDASDDERAIVESYRASFAVALDVVGIPRRVTMRVSTWPAVAIDLDVTDVFEQTPGPAAGARLS
>NZ_CP011125.1|WP_053236992.1|8273599_8274844_+|DUF697-domain-containing-protein
MTRRSDDDHPPSPPPHHGELDDLFAIVDRLPFFGSLKKDLTHLRKLLYDRRTPRVLAVGARGSGRTSLANSLLRLPALPLGEHAASPPDAWIRIDAGGRHLDWLEVASGPLEGGRLAMVRRALDESVPDVIVVAARADAPETEGAAARETLAQIHTMLAESKTIGDAKAARPATIGVITHVDRVTEPEAAESGVRFATEDLARLDAATLALKKQLEAGTTTKITRPIPVLAGGELGGPDQPVRWNVEEVAAAIHDALADEAKVEAVRALAVPVEMRRELARTIVNHCAAAAVTVGLMPVPFSDAVILLPLQGVMVSGVAYLAGQPWDRRAALEWLGSVGVMGGAAFGLRWGAQQLVKLIPGAGTLVSGSVAGAGTLAIGRSAVAYFVDGPGARTPRLQLPADASTPIETPPPTE
>NZ_CP011125.1|WP_053236991.1|8272771_8273527_+|hypothetical-protein
MHATQHATPSTERPRSAPAAKPAPPEDPREREAARIALEGTPLQRTAMAYRALRALIADPDDTKQVFYVGLLVNRGTYPTFLARFTTDDEGARLLRERPAIDRSTVDYDALRAMPASTLGGAYVRFLDANGLDPDLFQSPPGLPEVPSYIAQRMRQVHDLWHVLTGYDSDVAGEVALQAFTWGNTGMASAAAVTLAAGVRFSVTDPRIVRMAAAGYRDGRRAKFLAPIRIEDHFARELDELRAEWGIRAVR
>NZ_CP011125.1|WP_053236990.1|8271945_8272686_-|TetR/AcrR-family-transcriptional-regulator
MARTPARGRTSRAAAPSASSEKKAAPEARSTRRRRSPEEARRLILDATKTLLAQHGPDAVGLKEVAKAAGVSHALVSHYFGTYDALVEAALRDHMLETRVETLQRIADVAHAGPAEWVEMCFEQLAHPLSGRLLAWAILSGRMDSEDFFPRRDQGMRFVADAIEARVRAQLGEDRVPAREDIEFGMLLVFSAALGYSFSRTVLWESLSKKPSAERDRWFREKLGELVTDALPIARGLAHSGSERDE
>NZ_CP011125.1|WP_053236989.1|8271453_8271963_+|hypothetical-protein
MTTTITIPEPETNDLAIERLLTRRGWALDLAWVGGASALAVATMLGASALFALAVAATSALIGAAIGAGAPWLLSRRVRRLPVLVLLGAGAGLGANWGALSAASVALASDGGLGWVRAAELGGTAGLLVMGLFWLPAALLRASGRSTRLARIAALALSPVIAGYLLVAL
>NZ_CP011125.1|WP_053239058.1|8270864_8271326_+|carboxymuconolactone-decarboxylase-family-protein
MRARMKHPAMMVPDAMQALQALGAAIERAGVPRRTLELVNLRASQINGCSFCVEMHSRALKRSEEKDERIFAVAAWRESPHFTPAERAALALTEAITRVADRADPVPDELWREVTHHFDEPALAALVLGISNVNTWNRLNVATRQIAGSIRTD
>NZ_CP011125.1|WP_053239057.1|8269905_8270760_-|sigma-70-family-RNA-polymerase-sigma-factor
MEQLAERWLADRDHLRAVAYRMLGSASEADDAVQEAWIRVSRADTSEVENLRGWLTTVVARVCLDMLRSRKSRREDALDGHAERVGEGDPEAELALADSVGVALLIVLETLPPAERVAFVLHDLFDVSFDEIARIVDRSEVAARQLASRARRRVQGAPRPDDAAIARQRAVVEAFVAAARGGSIDALLAVLDPDVVLRADRAAVPAGAETEARGAEVVARRASQARARHGTLAVVDGAVGIVVAPRGVLRGVLTFTFAHDRITSVEVIADPERLRALDISVLPA
>NZ_CP011125.1|WP_157069745.1|8269238_8269832_-|hypothetical-protein
MALAFVAATSLLPASVRAQTAVHPSSDALYIGFRAEPGVAYLVAYDLDILVTDASTGISIGPSVSIAFGGDSSTDLGRQQEYLIAADFVRARLTVAQGYGLRATVLIGAGMYLVGLPEQERAPHVALLDDGTEVIVRERYASALLPGALLTGGVGGDWYFDAHWGIAAFLVGHVRLDDLNRMPALWIEFGAGVRWGE
>NZ_CP011125.1|WP_169791765.1|8278001_8278730_+|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase
MARHVCEADGAYDLSEDAYLMALAIALSLDDQAMRGLLLGSPFDRPWAERLKRLEDIVLGAVFLAVSAPVMLACAIGVKLTSKGPALFKQRRYGLNGKEFFVYKFRSMTVAEDGAKVTQATKNDARVTKLGAFLRRSSLDELPQFLNVLKGDMSIVGPRPHAIAHNEHYKKLIDEYMLRHKVKPGITGWAQVNGWRGETDTLDKMLSRVEHDLYYIQHWSVLFDIEIVLRTVFGSAVRENAY
>NZ_CP011125.1|WP_053236997.1|8278729_8280805_+|serine/threonine-protein-kinase
MSAPTTSTQRGATEAHDAEASKLVTFGKYLLLDKIATGGMAEVWLGKTVQDESVSDLLAIKRLLPRFSDDEEFLHMFVDEARIAGQLEHPGIVQIHELGKVGSSLYIAMEFVWGRDLLGILRRLRELSLPMEPTTIAYVGARMCEALHFAHTAKGKDGKPLNVVHRDVSPQNVLVSFDGKVKLIDFGIAKAASRSTKTQAGTLKGKVGYMSPEQVRGAPMDARSDQFAAGTCLYEMITGRPLFSRANNFEAMELVREADVPPLEEAAPGTPAKLVEIVMRALSKRADDRYESAHEMQKALTLFLAEAAPGYERFTLTTWLRGIFRDEMAEEKARLDVLDLIGRRPSVQPEAKRKRTNSSTRLEIGAHDLFDDDEDAETQIFEGSPLAKLEIEVRPVGPYEVFFQRDGADEGAKPSSGSHVRPLKATFRPGRTQAAESWRPPRTDLAELGPYRKPKEREVGRDTDPNPSAEKGPATSPPPGSESEPSVMVADELRTTMRDPDSNEKVLSTIPIDPEHLSLDPAEINSQVIRALLPTGKTDPAQRKAQQAASREPTGPHRASSENRRDPTTRRRILAEQSAPRRRRSDVVFFAIAAFFMLVVGAGATYWWLAGAATSSIEVRTAPMTSGAVLIDGVSRGRVPLRVEGLSPGRHTVTIVADGYEPTVREVQLAPRASAILELPMQRASGAAATE
>NZ_CP011125.1|WP_053236998.1|8280892_8281141_+|hypothetical-protein
MLTTSLLVYLALTFSLASSIVLWVAMIGVAVRRARTSEMHPGLSVVPPLAAVAAWRGGERELALGFAAVSIVYLVLLIAAHA
>NZ_CP011125.1|WP_053236999.1|8281137_8281806_+|hypothetical-protein
MTALRDVDPELARAARDRLARAQEPSPHVAPGLVARGIIGAVDAVYGSEGSFPKFRALEVIARVMYQAWESVAYGAISSDYRDVDARSGHARTIERSRHQQDNEQRHLFWMHALCERRGEREGWWRHRVVPRVLAALLYRLAWIAHWVDPAWSLHLNAELEDRAEREYLRFLAAHPELEHEPAGVHGFTSVADLLRSMVLDEREHKTESLAHAARLGELALR
>NZ_CP011125.1|WP_053239059.1|8281807_8282542_-|type-1-glutamine-amidotransferase
MQITSTKLRGKKIAVLAADGFEHVELSIPEKALRLAGADVEIVSLHPGRIRGMNMTAPTKTVRVDRTIDEVSVDEYDALFVPGGFIGPDLLRQSGPARRFVAAFDAAQKPIATLCHGPWMFASAGIARGRTLASWPGVRDDLVHAGATWRDEPVVRDRNWITSRGPQDLKQFVPAMLALFADSGLHAEDATAHRLQTGSSPAHESPPPMAVAVARMIPGPTIRTVAAAAAVAAVGALALRAVSA
>NZ_CP011125.1|WP_053237000.1|8282679_8282946_-|hypothetical-protein
MNIGDYSEWRRHRGDRAKYACFRCRVCFKWPHERAASVSGQRRCFARPLSVPTCPHCRATMRPMGYTYEPPPRQDRRAWERDARRYAR
>NZ_CP011125.1|WP_053237001.1|8282947_8283625_-|MotA/TolQ/ExbB-proton-channel-family-protein
MRWLAHHFEEGGWGMYPLVACLAVALLITIERACALLRARPNADALLDALRACLRVGDVTGAIAICERNRGPLARIALAGLRESLQSVPRIEAALATRWMLEAQPLARRLGYLQLIVQIATLFGLLGTVTGLFGGYGHTNADASSRATMLARGISESLNCTAGGLFVSMVALLALCLLDGRARTLREELEEGTLAIRNMLIDHREHLRWNGARAPLDRPTYRTAR
>NZ_CP011125.1|WP_053237002.1|8283704_8284838_-|epoxide-hydrolase
MKITPFRIDVSQNVLDDLRDRVARTRFPEAPEGWSAGTDSALMKRLTKHWLDEYDWRRHESALNAHPQFVADVNGTPIHFVHVRGRGPSPTPLLLIHAFPDSFHRFVDAIGPLTDPAAHGADPALSFDVIIPSLPGFGFSGHTAMSVDATADTLAALMKGLGYDRYLAGGGDGPIPMAMSHRHAESVAGIYCVDVGYPDGNTDFASLSPEEREFAQWIHAWWMREGAFNMIQSTKPSSLAFALNDSPVGLAAWLMILFASGAEDRVEERFTLDALITNAMIYWVSGTIGSAMRSYLESARAMYASPAAAPRGRSEVPAAVARMPLDAPLPRAWAERRVNVVQFTEMERGGHHSSWEVPDLFAKDLRDFLATLRRRSH
>NZ_CP011125.1|WP_053237003.1|8285176_8285842_-|AraC-family-transcriptional-regulator
MSARRQVRSSDSPFVERVTRVTYDAAVRELSTPDGTWDLVVIEREGRRLVLQTGLITRPVELENDAGDAYLAISFKPGVFLAKQPGVSTVDRGIVQPILSPRAFSMHGETLEIPTFDNADDFVARLARRDLLARDELVADAARGDVRAIGTRTLQRHFVHALGITPKQLAQIQRACRAVELLERGVAPAAVAIEVGYSDQPHMTRALKALVGRTPGQIRGG
>NZ_CP011125.1|WP_053234869.1|8287328_8288144_-|ATP-binding-protein
MKTLPSISPELKKVLKKLKLGPIIATLPDRMALAEMQKLSLEETLLLVLSDEIARRESSACARRAAKAGLDPDMTLERWDSSAKVRYDKRVLAELTSLRFIEASKNAVILGPVGVGKTFLASALGHIACRHGYNVIFTRADAMLRRLKQSRLDNSRDAVMTELSTIDLLVVDDFALEPMTRDESRDVYQLFVERSGRASTIVTSNRDTSEWLAAFDEVLLAQSAVDRFIHNAFDLVVEGESYRARLKPKVSDDDPPPSSPVEKKTLIGKRR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP011125_31

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_31

8727441-8727520

Orphan

Consensus_repeat	Method
GCAAGCGGGGCTGGGGCCCCGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_31

>merge|NZ_CP011125|31|8727441-8727520|CRISPRCasFinder
GCAAGCGGGGCTGGGGCCCCGCGCTCCGAAGCGCTCCGAAGCGCTCCCGAGCACGCGCAAGCGGGGCTGGGGCCCCGCGC

>NZ_CP011125|31|26|8727441-8727520|CRISPRCasFinder
GCAAGCGGGGCTGGGGCCCCGCGC	TCCGAAGCGCTCCGAAGCGCTCCCGAGCACGC
GCAAGCGGGGCTGGGGCCCCGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053239085.1\|8725215_8727045_-\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NZ_CP011125.1\|WP_053237311.1\|8723103_8723973_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223462
NZ_CP011125.1\|WP_053237304.1\|8716637_8717447_-\|PaaX-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225864
NZ_CP011125.1\|WP_157069870.1\|8737683_8738118_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237318.1\|8734149_8734728_+\|HdeD-family-acid-resistance-protein	unknown	unknown	gnl\|CDD\|225786
NZ_CP011125.1\|WP_053237319.1\|8734875_8736750_+\|DUF4215-domain-containing-protein	unknown	unknown	gnl\|CDD\|162730
NZ_CP011125.1\|WP_053237320.1\|8736913_8737687_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NZ_CP011125.1\|WP_053237305.1\|8718753_8719347_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237315.1\|8728778_8730359_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_075098116.1\|8730736_8731603_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP011125.1\|WP_157069859.1\|8731599_8732625_-\|stage-II-sporulation-protein-M	unknown	unknown	gnl\|CDD\|224219
NZ_CP011125.1\|WP_157069854.1\|8719438_8720629_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069852.1\|8717527_8718442_+\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|236213
NZ_CP011125.1\|WP_053237308.1\|8721524_8722190_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP011125.1\|WP_053237312.1\|8723981_8725157_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP011125.1\|WP_157069857.1\|8727682_8728762_-\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP011125.1\|WP_053237322.1\|8738121_8738940_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237310.1\|8722566_8723097_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237317.1\|8732621_8733929_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP011125.1\|WP_053237307.1\|8720635_8721508_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053239085.1\|8725215_8727045_-\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	1.09881e-135
NZ_CP011125.1\|WP_053237311.1\|8723103_8723973_+\|hypothetical-protein	gnl\|CDD\|223462	COG0385, COG0385, Predicted Na+-dependent transporter [General function prediction only].	1.10476e-14
NZ_CP011125.1\|WP_053237304.1\|8716637_8717447_-\|PaaX-family-transcriptional-regulator	gnl\|CDD\|225864	COG3327, PaaX, Phenylacetic acid-responsive transcriptional repressor [Transcription].	8.36068e-15
NZ_CP011125.1\|WP_053237319.1\|8734875_8736750_+\|DUF4215-domain-containing-protein	gnl\|CDD\|162730	TIGR02148, ORFveg106_random, fibro-slime domain. This model represents a conserved region of about 90 amino acids, shared in at least 4 distinct large putative proteins from the slime mold Dictyostelium discoideum and 10 proteins from the rumen bacterium Fibrobacter succinogenes, and in no other species so far. We propose here the name fibro-slime domain.	2.02862e-22
NZ_CP011125.1\|WP_053237320.1\|8736913_8737687_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	1.80597e-42
NZ_CP011125.1\|WP_075098116.1\|8730736_8731603_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	5.45005e-12
NZ_CP011125.1\|WP_157069859.1\|8731599_8732625_-\|stage-II-sporulation-protein-M	gnl\|CDD\|224219	COG1300, SpoIIM, Uncharacterized membrane protein [Function unknown].	6.01547e-30
NZ_CP011125.1\|WP_053237318.1\|8734149_8734728_+\|HdeD-family-acid-resistance-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	1.74795e-21
NZ_CP011125.1\|WP_157069852.1\|8717527_8718442_+\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|236213	PRK08272, PRK08272, crotonase/enoyl-CoA hydratase family protein.	4.48409e-174
NZ_CP011125.1\|WP_053237308.1\|8721524_8722190_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00250311
NZ_CP011125.1\|WP_053237312.1\|8723981_8725157_-\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.42027e-55
NZ_CP011125.1\|WP_157069857.1\|8727682_8728762_-\|FHA-domain-containing-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.81021e-16
NZ_CP011125.1\|WP_053237317.1\|8732621_8733929_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	4.53676e-35

>NZ_CP011125.1|WP_053239085.1|8725215_8727045_-|glycoside-hydrolase-family-15-protein
MASRIEDYGFIGDMKGSALVSRHADIDWLCVPRFDSEACLAALLGRDEHGRWALRPTSRVLETRQRYRGDTLVLETELECDEGVVRIVDFMTPTSDRSDVVRIVEGVRGAVTLEMVLDVRFGYGASLPWIRSYDRQVTLVAGPDSMHLRASVPLTSTRTRVSSIFTIRAGEQASFVATWAASDCAAPPPLDAGRALQETERFWLEWAGRCTYRGKWRDAVVRSLLTLKALTYAPTGGIVAAPTTSLPEEIGGVRNWDYRFCWLRDATLTLDALMIGGYSDEARAWRDWIARTVLGDLSRLQIMYGLAGERRLTEFELDWLPGYEESRPVRVGNGAWNQFQLDVYGETLSCLYQARRAGLSALEEAWDIAHELLERIESIWQKPDEGIWEVRGGGLRHFTHSKVMAWVAIDRAIRLIEEFGVGGERGANDLAHLRALRERIHEDVCTRAWNEGIGAFAQSYGSDALDASVLIIPHCGFLPADDPRMLSTVRAIEKRLVRGGFVQRYSTELGLDGLPGDESPFLACSFWLADNYAFQGRIAEAEELFERLLAIQNHLGLLAEEYDPNAGRQIGNFPQAFSHLALIFTANAIETCRAKKTTRAQPAPQPAHP
>NZ_CP011125.1|WP_053237312.1|8723981_8725157_-|sensor-histidine-kinase
MPVSTDPRCAELARILRREKQPILDTWIARVRADERVPRARALSDPELLDHSPMLLDEVSDALEGHDAPQRRHDAASEHGAQRAGHGYDIRAVVREIALLRDIIVERLAPDEQLLSGPPGRTFHGVFDDSMAASVERMESVARAAIARERDEAQRAKLRAERSDAEKDLFVAVIAHEIRTPLTAVLGWIALARERVREDELLVRAIDTIDRNVAVLRRLVEDLLDLARVRSGKLSLDLQRVDAARFVTAAVESARPHAAGKGVDLSIEHIAPAHVQGDPDRLLQVLSNLLVNAIKFTPRDGHVVVRVARAADRVRVEVSDDGPGIAPEIRASVFDPFKQGDPLAGSRGGGLGLGLAIVREVVAAHHGSVGAESEGVGKGATFWFELPLAPP
>NZ_CP011125.1|WP_053237311.1|8723103_8723973_+|hypothetical-protein
MSDAIRTVIAVALPAMMFAHGLSMRVDERRAAGADRPWWMSRAVLAVIVLVPLFALLVLLVVPTTPRVRVGIAIMAASPVAPLALGRIVGQRGDVPFATAMHLTLGSLAVFTTPIVLAALGAVLGFRASVGPSQVAGQLATALLAPMVLGIVAARRAPALARLARPIGAIAKLALAIAVVLILVASSGSIFAMDVRSYVAMTLFVAGALAIGHLLGGPRREDRVTLALETSFRNPGLALLIASVAFPEGRPLAVLVPYIVTAFVVQSLYLAAWRRRDIDTEALGAPAPA
>NZ_CP011125.1|WP_053237310.1|8722566_8723097_+|hypothetical-protein
MRPERRQGSIHRNGAAALLGSALALGACATSGSGRGELQTVGKQREGDVEFAWVAEPDATSGDIAATLPDGRVFRGSFLQVTSTTLGTDISPYWTTWGHTWYGGYGYPDMYYDYPGFVRTYSGRVIAQLEGPEGQRMRCAFVLARPEDGPASGGMGDCELSTGEAIEYATLRGEDD
>NZ_CP011125.1|WP_053237308.1|8721524_8722190_-|hypothetical-protein
MPKAWTNEVVARSLGVALCAGCAAQPSSPPATVVTHGGEQARATAPALIEVDESALAALPEVTAPGPTTVAAPTPDATPAPIEAAEVDADVEEDATALACPSDVAGLEARAVTTARGAALVLRTSEPEQVDELRRRVRELASALDEERRERATITHTPRFAASGAMHETHEVRLHDVARGVRMELIAREGDAAARRELRDELRDDARVLGEGRCPLRFQTT
>NZ_CP011125.1|WP_053237307.1|8720635_8721508_-|hypothetical-protein
MQHERSNVGACWLAAIITVAASAGASRASAQVAEGQLVYVQGDDGALQLYRRIDAPDEGDGRARFVRVDRTQPVEGQTIPVVPRTAVLASVSTDTAQIEIVEPPPMTTTTSGGVELGSEPRTEGPMYIEQPAPELARFRLGASAIGGGIIGDLDGWLVGANLRVGTQLGPWFAFYYAPTFLYGGLSDSDGAFVFWSSFVGEVTLWDIVSVGVGPSVDIYDDCDPRVRANAACSRVDETFFGLHGRVALNLGAGGPGERGAVSVSFEVHPTWFGEDLSAVAMLGGVGAELY
>NZ_CP011125.1|WP_157069854.1|8719438_8720629_+|hypothetical-protein
MPLSPVGTARASWLRMAQPALFAGDPFDRILNALDPRAGPKRRVVERCAAIVLIAWAPLAVASYAEGTFRGAPGSFASDILVHVRLLVSVPLLMIGEHAVARRFGAALEHLERAGLVPEDRRAAYRAAIASVERLHRAVWPDVVLVGLVAAFAVDDITAGRLERWMQPALVPGATLSLAGAWDLCFSLPVYRFLVGRWLWHFALWFLLLARVARVPLRLEATHPDRMAGLRFLSDAHESLAWLVLALSCTLAASLIMLLRHTGEAVDALDPTVLLFCIAAPLLAVSPMTVFAWPLERARRERHDDYGVAAADLSRRYVAKHIAGRSATPFPVDADEPSTHIDMSSSFQNCIDMRRAPVRRTTLILLFACAAVPMLAVYLQQLPMVEIVKRLRGLMG
>NZ_CP011125.1|WP_053237305.1|8718753_8719347_-|hypothetical-protein
MRVERCVLVSLCLALVSVAGRAAAQGDEGFWVRPRVGGSLVLGGTLGEPEGWLAGGNVRVGAQLGEYFATYYQANLMYAALAGGTEIDDRDDDGDSDNAFVMWNVFLFEATVLDAISFGVGPSADLYEDCEDDVQANRGCARDSLYFGMHGRVSVGFGATDRGRRQALTLSFEAHPTWFDEDHMTVSMLGGIGFDLY
>NZ_CP011125.1|WP_157069852.1|8717527_8718442_+|crotonase/enoyl-CoA-hydratase-family-protein
MDTLKTMTFEVTGRIARITLNRPKRGNGITMDMPRELAACVERANLDPSVHVIALSGNGSGFCGGYDLVESAETFTLGSEDASRVPGSPLDPAVQLQNHVPNGAWDPMVDYAMMSRNVRGFMSLFHGEKPVVCKVHGFCVAGGTDMALCSDLLVIADDAKIGYPPARVWGSPTTSIWVHRIGLEKAKRLLFTGDCLSGEEAHEWGLAIESAPPDRLDERFEILLARIAKMPINQLVMMKLLLNQTLMAQGLHTTQLVGTVFDGITRHTKEGYAFQQRAAEVGFKQAVRERDEPFGDFGLSTFKG
>NZ_CP011125.1|WP_053237304.1|8716637_8717447_-|PaaX-family-transcriptional-regulator
MRVATPPNPRDLILKLLLGAEGGSFSARDAVAACALFGIRENNARVALVRLSATGMIEGTGRGAYRIGPSSSDLAEEVRAWRAAESRVRKWNGAWLVVHSAALLRSDRAAWRRCDRALRMLGFRELEKDLFVRPDNLVGGVKSVRARLRKLGLAAEAPVFTADDLDEELDARARALWTSDALTESYARTRRELERWLQRMRTLEPEVAARESFLLGSDAIRQLVFDPLLPDPLVDVSERRAFVDVVKRFDEAGHAIWRTVLGASAKEVP
>NZ_CP011125.1|WP_157069857.1|8727682_8728762_-|FHA-domain-containing-protein
MNDQNKKTLRQFQCRDYLWEIFEQMSGELECSVDYLINEAMRQYARSRNYGARTGPTPDPTGQRARPEPTAQQGRQRVPSQPAIPSAPPPPPARGSYPQPGAPSYGQPSPAPVPGSAGYPPPPPGRSSPGGYPAAPPAQQPPAAYGGAGYGAPAPQAYGAPPMQPQSQAGGYGGAPYGAPTPGYPAPPSYPAASSPGGYPAPPGYGAPPPRPAAPAAPSSYPPPPQTTRPPAYGSGGAPASYGAPPPLPSAAPPLPGAGGGTHPAGMPTLFVIFNGQKFPVNKEEFIIGRGTKTADLAIKDGNISRRHAAVIFQNGGFYMKDLGSTNGVEFQGRRVDGKRIEEGDVYQLCDYELRFTYR
>NZ_CP011125.1|WP_053237315.1|8728778_8730359_-|hypothetical-protein
MHLHVRSLRNLFTVLCSVALLAACAVTHEDVDTWIGTVRGPGKIKAVLLSDKYDDELRIHAGLALVRMERQDVEGVTELQSALRQLDDETRRRIVDGMTPGLLELMRGEGQPQQAEEGPPPTLQVRAKDAAFLVLQYASPTQQGQLTDGVVGWFVEDFNGRSLAGNFSAEQVVRQLGAPAAQRLVDAMNARIPQQALVKIAELVAALGSPETKTRAAERLVAIEREMEGPEFGTWLGERIRTQLAAAGGAAPDDARVQAAVALNREQFITTGALPAMHHLADQPTVSNRLLEMATQTAGSTEDRRVVALQAMEGHVRPDQNATLLALALDQSSPVRVRDYAFDRIADSRAREAIPQLWPLATSADNAQWRQRWRVGSLILTLGGPEILPEWLGRLPNARDIQYAREELNGYATRIAAMRPEPDALMTAQLASPNWWNRAIALYYFERQGDEADLPRIQAMAGDTTATRGEHWEEHDTVGKIAQDVVTAIRERMTRGAAGAGATGATGAGGTGGAAAGGAGSAGAPG
>NZ_CP011125.1|WP_075098116.1|8730736_8731603_-|RDD-family-protein
MSERSVRLLAPEGTEIGLALASVGERAIAYVLDVVFSQLLLLLFVVIGLVATVITTSEHVLALLILGAFVIRHGYFLFFETRFQGSTPGKRLLRLRVVSRDGAQLGLDAIVARNVMRDLEVMLPLMLLVAPEAAIGRAPAWLAYPAVAWLMLVALLPVLTRERTRAGDLVAGTVVVRVPRSELLRDEARGTRATRLRFTREQLSVYGEHELETLAQLLRSAEAGKADDDDLRVVATTIARRIGFEGNEPQRAPGTFLRAFYRDQRAELERNLVLGRRIADKHERNNKR
>NZ_CP011125.1|WP_157069859.1|8731599_8732625_-|stage-II-sporulation-protein-M
MTTDRVSDPMRVEPRSVRFRAEREAEWSELEQMLDRALAGGLRRLTEEELHRLPMLYRSAVSSLNVARKTALDRALVTYLESLVGRAYLAVYTSRRPERGPLRRFFFERFPIAVRSMARELALSTAIFALGVLVAYAMVRADAEWYFAFVDAGLAGGRSPGASTEFLRDALYAPQHDGLSIFASSLFSHNAGIGLLAFALGFAAGVPTALLVFTNGLMLGGFLALYDERGLLVPLLGWLLPHGVPEIGAILLCGAAGLALGRSVLAPGARSVRDALVDAGRRGAVVAAGSVVLFLIAGFVEGVFRQVVTHDLLRFALALFNAAWLSAWIVLGGRALVRRRS
>NZ_CP011125.1|WP_053237317.1|8732621_8733929_-|DUF58-domain-containing-protein
MVPTPRLLVVLLAIAPLAILPLAIEPAWIALAVAWVAVAVAVGVDLALLASARLDVALQRPASAGVGRAVRAKAAIDLRAAAPLHGTLRAIAEAPLSASAPIAVRIPRGASELPIDLHADARGTGALREIWLRVTGPLGLVARIEKVDRGAGPIAVVPDVEHVDRTTMAVLGAQPMLSGLKREKWTGEGGEFESLQQYTLGMDLGSVDWKASARHQQLRVRRFHVERRQRIVVCLDVGRAMRDPIQGLERLDHGVHTALVLAKAALRAGDLVGMHAYGGEPRAWVPPRSGVGQFARLRQAAAALRAETDETNHVLGLHDLLRRLSRRTMVVVFTEFSDATTAELMLDALGQLARKHVIVFVALDDPLLEEPLSTLPSDASDLAAAVVASNLAQRRHLVLARLPRLGVHVVHSRPGAVAADLVERYVNIKARGLIG
>NZ_CP011125.1|WP_053237318.1|8734149_8734728_+|HdeD-family-acid-resistance-protein
MTTNRSFSYGWAAGVAMGVLMILGGIFCIGASLTTGLVTVVFAGVLLVAAGVSEIIAGFRLRRHGSMWLPFLSGALSIVVGVAIVSRPFTGLAVATLFIGAFMVAAGLVRGIAAVADRYPRWGWDALYGVVALLLGVYLLASWPVSALWLVGTIVGVELVSRGIAWVVGSLAMRRVVRTREGRIIEGAAAPA
>NZ_CP011125.1|WP_053237319.1|8734875_8736750_+|DUF4215-domain-containing-protein
MSFVSLSFVCLTACDPDDPARPGPDGGGALGTFDAGMPLDAAVPPRDALPRTDAGDVCGDGMRGITEACDDGDADPGDGCSETCVVEEGFRCPPAGGACRAIVCGDRRVESPERCDDGDADAGDGCDASCQVEDGWACTIPGLECQAASCGDGIVAGFEQCDDGGAATAGCSAECRLEPGYHCPTPGAACAPTRCGDGMRQGVEQCDDGNVRAYDGCDNECRNEPSCMGGTCAATCGDGVILPGTAEDCDDGNTLSGDGCSATCDEEDGFECSLVEQPLPPSIRLPVVHRDFRGGDQAGSPTHPDFNTRGGDGITFDMVSDTLDAERRPVFSGLVVGGSGALSTESFHDWYRDSARNTPVLSTIELTRVGTTDQYEFASTAFFPLDGQGWDSPTSTAPETYMEDHNYGFTTEIRYWFQYQGDERLDFRGDDDVWVFVDGHLCLDVGGLHPAVPAVMDFANPANAGDARQTAIVTECRDRLTVGGVYEVIVFHAERRCCASNFRLTLSGFVTRESRCDWTCGDGIVTRYELCDDGPGMNTGEYGRCGADCRSRGPYCGDGAVESGVEQCDEGPDNDGRYGGCNPDCTAGPRCGDGVRQGAEECDAGEENGAPTSGCDAECELTLV
>NZ_CP011125.1|WP_053237320.1|8736913_8737687_+|RNA-methyltransferase
MATTRYGEILADLLALRACKGMDSRGRLLLEGVRMVLSARRAGVALDALAYAPEHGGDAPAAQQLMAALEREGVPRARLSARDFSRISYKADGVIAVVRPAWPTLDEVLRRSGLVVALDAPSDPGNVGAVIRTANAWGAAGVVVLGDAEKITHPKCLRASTGALFHTPTCAATRDELLARALGRRLVVLVPDGDRAWRADERAIVVLGNEKRGVHPELVRAASERVAIPMTGVVDSLNVSNAAAVILWDAFRARSTP
>NZ_CP011125.1|WP_157069870.1|8737683_8738118_+|hypothetical-protein
MTEPWLLHLPHRALRVGLDVARIARARGDLRDPRELEFRFGLHSHERRFVRELLAARTQLWVFRCDQLRACGDLVVVDMSAPRALRRCVVVELKQRVRVRAAPNHVQLANHTIAVAELAARGIVAPDPPVTALLGEVGVGTFAS
>NZ_CP011125.1|WP_053237322.1|8738121_8738940_-|hypothetical-protein
MIADRDLDLVALAPLAMPRTIATSWLRLVVRDESGCDRGARTLDASDARVWCDASFADDHVVVVIEQTATGAQQIQAFHVETGAPAGLQVDVGDARIATHPALREVVIATSRSLAVWGIDGTRRGEWSGVFVGESALGASIVVHVDEDLISVLDRARGARRHVRNPRRRDPEVVSLDPDEQHVDVVWSGGKVDRISLGDGHLAPLGHHLGARWMVSRPDRVYTADEHVVIERCVVSGATRAIDGVRGPLGWESGRGVLLGVSRDGRVVAIDG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP011125_32

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_32

8746900-8747008

Orphan

Consensus_repeat	Method
CTTCGGGCGACCAGTCCAGCTCGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_32

>merge|NZ_CP011125|32|8746900-8747008|CRISPRCasFinder
CTTCGGGCGACCAGTCCAGCTCGAATCGCGATGGGTCGGCCCTCCGGGCGACTCAATCCAGCTCGACGTTCGATGGGTCGACTCTTCGGGCGACCCAGTCCAGCTCGAA

>NZ_CP011125|32|27|8746900-8747008|CRISPRCasFinder
CTTCGGGCGACCAGTCCAGCTCGAA	TCGCGATGGGTCGGCCCTCCGGGCGACTCAATCCAGCTCGACGTTCGATGGGTCGACTC
TTCGGGCGACCCAGTCCAGCTCGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053237329.1\|8747223_8748012_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237336.1\|8752259_8752634_-\|YciI-family-protein	unknown	unknown	gnl\|CDD\|226318
NZ_CP011125.1\|WP_053237335.1\|8751009_8752263_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|227277
NZ_CP011125.1\|WP_053237334.1\|8750499_8750928_-\|glyoxalase/bleomycin-resistance/extradiol-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|319899
NZ_CP011125.1\|WP_157069874.1\|8745639_8746788_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237331.1\|8748884_8749667_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP011125.1\|WP_157069870.1\|8737683_8738118_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237320.1\|8736913_8737687_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NZ_CP011125.1\|WP_157069872.1\|8741925_8742768_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|284258
NZ_CP011125.1\|WP_083458246.1\|8742899_8745548_+\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NZ_CP011125.1\|WP_053237337.1\|8752727_8753444_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|225136
NZ_CP011125.1\|WP_053237323.1\|8738939_8739896_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP011125.1\|WP_053237325.1\|8741121_8741910_-\|DUF4129-domain-containing-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237338.1\|8753433_8754018_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NZ_CP011125.1\|WP_053237330.1\|8748089_8748806_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237333.1\|8750078_8750486_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
NZ_CP011125.1\|WP_053237332.1\|8749663_8750077_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237324.1\|8739892_8741125_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237319.1\|8734875_8736750_+\|DUF4215-domain-containing-protein	unknown	unknown	gnl\|CDD\|162730
NZ_CP011125.1\|WP_053237322.1\|8738121_8738940_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053237335.1\|8751009_8752263_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|227277	COG4941, COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription].	5.15458e-180
NZ_CP011125.1\|WP_053237331.1\|8748884_8749667_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.04697e-14
NZ_CP011125.1\|WP_053237319.1\|8734875_8736750_+\|DUF4215-domain-containing-protein	gnl\|CDD\|162730	TIGR02148, ORFveg106_random, fibro-slime domain. This model represents a conserved region of about 90 amino acids, shared in at least 4 distinct large putative proteins from the slime mold Dictyostelium discoideum and 10 proteins from the rumen bacterium Fibrobacter succinogenes, and in no other species so far. We propose here the name fibro-slime domain.	2.02862e-22
NZ_CP011125.1\|WP_053237334.1\|8750499_8750928_-\|glyoxalase/bleomycin-resistance/extradiol-dioxygenase-family-protein	gnl\|CDD\|319899	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins. The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.	6.21571e-36
NZ_CP011125.1\|WP_157069872.1\|8741925_8742768_-\|hypothetical-protein	gnl\|CDD\|284258	pfam06790, UPF0259, Uncharacterized protein family (UPF0259).	0.00688793
NZ_CP011125.1\|WP_083458246.1\|8742899_8745548_+\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	2.14855e-161
NZ_CP011125.1\|WP_053237323.1\|8738939_8739896_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	7.8173e-96
NZ_CP011125.1\|WP_053237320.1\|8736913_8737687_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	1.80597e-42
NZ_CP011125.1\|WP_053237338.1\|8753433_8754018_-\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	9.8138e-39
NZ_CP011125.1\|WP_053237333.1\|8750078_8750486_-\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	2.74773e-11
NZ_CP011125.1\|WP_053237336.1\|8752259_8752634_-\|YciI-family-protein	gnl\|CDD\|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	1.92858e-44
NZ_CP011125.1\|WP_053237337.1\|8752727_8753444_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|225136	COG2226, UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism].	4.89923e-15

>NZ_CP011125.1|WP_157069874.1|8745639_8746788_-|hypothetical-protein
MASCKERARPAPTTARSETRTVREMASRAVAGLLAVSVLACGSGSHRVCVPPSAVVALPVGHAPVVAIDGPSAGPGIPMAVGRTHVLVAEPEGATQLVLRDLPSMRPVWRLSVPAGVWSADVDEPDDEVVVSARSGEIILVRGGSVAWRRADVAPVRASFFGPYVLVDRGGMPPLVLRSLDGRETQEPEGQLFDHAYPFLITGQLGVPMTSEHVNAVSLWRADAGRGLAALWSQSEVRLAHSAGHWVAVERGDGNVIVDARTGSVACVMPPESNIQLESDGAEGFYVTLEHDVCRFSGRDWEWCIDRAGALHVERFGADAILLGEDVRQIDRGSGALVRRFVLPPDFVSLSRDIRARRLLTTDRCFIVSDVAIGSYVHHCSR
>NZ_CP011125.1|WP_083458246.1|8742899_8745548_+|DNA-translocase-FtsK
MSAHESTIGVLATTEGGRRHEVLGILSGAATTLLALSLYTYDARGGENWIGPVGEWIANIAATAFGAAAWVVPFELSLLTIRLFQRRRSPVGLAHLASTLVIVLVGCAMVHLAMPGEEVLGGHLPGGMFGEVLGEVLRSLLGLVGAFVVGTAVILVTMVLRTSFSIVGAARTVFGGAAAGASAAREWTSSVWEAWQEAREIERREREEEAARNAPRIVVPGASQSEADEELEEEAIAEEDLAPVEPAPEPVVVEKKAKKSRAKKEKPATIDTTPAAKPAKAARVAAPVIEEEDEEEIVASAEEAYEEDEVEEPAPPPLPSKRPSKPAPAVAAKAEPVAKGPTIVAPRADVVKQEPARESDEIEQKGEYVMPPTSLLDSPPSQQIEIDAATLQNNAVRLVQKLEAYGVKGRVDEIHPGPVVTMYELEPESGTKVSKIAGLADDLAMALAAQKVRIVAPIPGKARVGFELPNKHRQTVFLRDILEDRRWEENAEKAALPTAFGKDIAGQPVYGDLAKMPHLLVAGATGAGKSVGLNVMLCSLLMKRTPEEVRMLMIDPKVVELAVFDGIPHMLLPVVTDMKKASLALRWAVDEMERRYQLFADAGARNITTYNERVEKVLRGELAPEKLAPKKAGKQKAIGADGEDVYLNPVDDEAADAVPMPTKLPYVVVVVDEFADLMMVAAKDVEAAIARLAQKARAAGIHVILATQRPSVDVITGMIKANFPARIAFKVSQREDSKTILGRIGAEHLLGQGDMLMIPPGASDLRRVHSAYVSEHEVQGLCDHLREQGKPVYDEKILAPRDEESGEVLGDDGPSHSDDPLYDRAVACVATAGYCSISHIQRQLGIGYNKAAKLVEKMEAEGVVGPATGKAGGRREVLINAL
>NZ_CP011125.1|WP_157069872.1|8741925_8742768_-|hypothetical-protein
MENQTWGAPNAPPAPLELGDAIASTFRAVGQNLVPFLVISAIVVLPTVIVQTILEVLIYNVTQQSLASTRPEEALSMLGLLSLGYIGVLGLIMLMYAFGQGAIMYLTVESLVGRKASVGDAVRAVLGRIVPLVIASFLVAFVTGIGAMFCFAPGIIAWIWLSAALPACLVERLGPIQSMQRSIELTEGHRMTIFLIFLVLFGGFFGVTLCVAMPARLAGGMTPGAIPNPLDPLQLAAKLVMFVVQLGSTMVLSAAIAVVYAKLRGLRDGVDAQALARVFA
>NZ_CP011125.1|WP_053237325.1|8741121_8741910_-|DUF4129-domain-containing-protein
MRGLATVIAAGASIMLALAVVPAAAQEDPAAVAARVREQGGYPADVTVLVPEHESGGAPEGAEGAGRGPRGETSIDGERESPDPGPQVELPFARPLMDWLASVLASLSGPLGYVFLALGLAVLALVIVFFAASMRFRAPRLEASARDESVGEAAIDPLLVGTGESADALAAQGRWREAIHALFLDSLGRVGGAEGRHRSRTARELVRAIDGRRAGRAELESLLDLTERVWFGARDADETQFRDARALADAVPRGAVIEEDAS
>NZ_CP011125.1|WP_053237324.1|8739892_8741125_-|hypothetical-protein
MSDRALFGDRVRRVVIAVAVMSLVATVGALVFGRRLTTPEAQPRDSYGAGALGHRAFLETMRALGVRVQRWTRPEWDSVSAPLWIIEPNQPWVMVQSRTTTLGELVRARADAERVTVIVLPKWQPGMLGMVADEDAIEIAAILTELPFAVSLVRGPIEDDWRTIDAHELARDATRRLELRWPQRVQGGVPVLWDDEGSFVVRDDKALIYVVSDPDLLHSFNLQRGAHAALWRDFTRDTLHAEDIVIDEVFHGAVRTRSLPELFGRWPGVLVLVHGAIVALVVLLMGRRRFGPPDPIPEALGRGPREVIDVAASVLANGSRETTLALRYVEDVIADLHRRLGLSEAATADARAALIDQAAERRRVGASAAKLLADARAVEKTRRRREALVIARRAAELRAALMGTKKEERA
>NZ_CP011125.1|WP_053237323.1|8738939_8739896_-|MoxR-family-ATPase
MTPDVVRHHLRALSEQIGRVVYGAEEHTRLAFVAIAVRGHVLLEGVPGTGKTLFAQCLSRALGLPMRRLQCTPDLMPGDVLGANVFDFRTQTFHLTQGPVFTEVLLADEINRTPPKTQSALLEAMQERSVTIDGTTHSLSERFTVIATQNPVEQEGTYPLPEAQLDRFLFKLDVGYPAFEQELRAVLTHGGQAGMPPIDALGIEPVMDPQQIDQLRTMPGRVHLDPKIGEYVVGLARATRQHPALAVGLSPRAATMLAAAARAAALCAGRDFVVPDDVKSLFVPLAHHRVVITPSAEMEGVRVETALAEILAQIAPPR
>NZ_CP011125.1|WP_053237322.1|8738121_8738940_-|hypothetical-protein
MIADRDLDLVALAPLAMPRTIATSWLRLVVRDESGCDRGARTLDASDARVWCDASFADDHVVVVIEQTATGAQQIQAFHVETGAPAGLQVDVGDARIATHPALREVVIATSRSLAVWGIDGTRRGEWSGVFVGESALGASIVVHVDEDLISVLDRARGARRHVRNPRRRDPEVVSLDPDEQHVDVVWSGGKVDRISLGDGHLAPLGHHLGARWMVSRPDRVYTADEHVVIERCVVSGATRAIDGVRGPLGWESGRGVLLGVSRDGRVVAIDG
>NZ_CP011125.1|WP_157069870.1|8737683_8738118_+|hypothetical-protein
MTEPWLLHLPHRALRVGLDVARIARARGDLRDPRELEFRFGLHSHERRFVRELLAARTQLWVFRCDQLRACGDLVVVDMSAPRALRRCVVVELKQRVRVRAAPNHVQLANHTIAVAELAARGIVAPDPPVTALLGEVGVGTFAS
>NZ_CP011125.1|WP_053237320.1|8736913_8737687_+|RNA-methyltransferase
MATTRYGEILADLLALRACKGMDSRGRLLLEGVRMVLSARRAGVALDALAYAPEHGGDAPAAQQLMAALEREGVPRARLSARDFSRISYKADGVIAVVRPAWPTLDEVLRRSGLVVALDAPSDPGNVGAVIRTANAWGAAGVVVLGDAEKITHPKCLRASTGALFHTPTCAATRDELLARALGRRLVVLVPDGDRAWRADERAIVVLGNEKRGVHPELVRAASERVAIPMTGVVDSLNVSNAAAVILWDAFRARSTP
>NZ_CP011125.1|WP_053237319.1|8734875_8736750_+|DUF4215-domain-containing-protein
MSFVSLSFVCLTACDPDDPARPGPDGGGALGTFDAGMPLDAAVPPRDALPRTDAGDVCGDGMRGITEACDDGDADPGDGCSETCVVEEGFRCPPAGGACRAIVCGDRRVESPERCDDGDADAGDGCDASCQVEDGWACTIPGLECQAASCGDGIVAGFEQCDDGGAATAGCSAECRLEPGYHCPTPGAACAPTRCGDGMRQGVEQCDDGNVRAYDGCDNECRNEPSCMGGTCAATCGDGVILPGTAEDCDDGNTLSGDGCSATCDEEDGFECSLVEQPLPPSIRLPVVHRDFRGGDQAGSPTHPDFNTRGGDGITFDMVSDTLDAERRPVFSGLVVGGSGALSTESFHDWYRDSARNTPVLSTIELTRVGTTDQYEFASTAFFPLDGQGWDSPTSTAPETYMEDHNYGFTTEIRYWFQYQGDERLDFRGDDDVWVFVDGHLCLDVGGLHPAVPAVMDFANPANAGDARQTAIVTECRDRLTVGGVYEVIVFHAERRCCASNFRLTLSGFVTRESRCDWTCGDGIVTRYELCDDGPGMNTGEYGRCGADCRSRGPYCGDGAVESGVEQCDEGPDNDGRYGGCNPDCTAGPRCGDGVRQGAEECDAGEENGAPTSGCDAECELTLV
>NZ_CP011125.1|WP_053237329.1|8747223_8748012_+|hypothetical-protein
MAVGILPNDSPIYFHSPRFDGPSGVLLVRRLIKHAPADPSPLLRRVLRQMRTDGEALRVVIQERDAASPARSRPFGLAHARAWSALHARLDAGTKLATDVYPLAPRAAELIESIFPNGLVFVAGNYDTAFFEGETRLAKIVERVERDVIAIAGAPFLDGVRITHAALGEVLGLGRSTPEVPSTTAVQDAIARTMKSVAAYSRVLVAELDEDDEASVARFRRAVGPLDAYRASTRASADQPQVEPTPGDDDPDEPLPPTPPVS
>NZ_CP011125.1|WP_053237330.1|8748089_8748806_+|hypothetical-protein
MVRSFALLMLVLVGCSPAPRATSDASASRDASTSTRCVAPEGVSASPRTIDEVVALINALPSPVTIPCFLEALDRPLYVEATLSRVSAQPAFGERSPRIFLFVGDLVLSIVPDGEGAPLLEMSEFVEETRSRKAELHMPIATPVSSAAPYERVLYETGTTCGGCHRSEERDETIDFTDAFVSGALRPRDDDLVDLDALRSEWLACSPQEEPDRCAMLEALFAHGLVAHRSFPEHIPTL
>NZ_CP011125.1|WP_053237331.1|8748884_8749667_-|alpha/beta-hydrolase
MTSFVTSKDGTRIAFDRRGRGAPVIVVGGILCDRDRTRPLAHELASRLTAIDYDRRGRGESGNRAPCSLEREIEDIAALIAEVGGSAAVYGHSSGAALALNAAVRGLAITKLVLHEPPYGGDDDESVRGARGLAEQVRDLLHEDRRAEAITTFLGAAGVPPEMIEAMARDPKMLAMAPTMLHDFEVMGELRTGGVIPRELVRAIRIPTLVLAGTESAPFFRDTAKRIAELLPDGRYQVLDGQDHGAAPDVVAPIVATFVA
>NZ_CP011125.1|WP_053237332.1|8749663_8750077_-|hypothetical-protein
MSTSLTLVPSALRSTRAVLAGALVVAVVSTAIDMVLHATGIYPPLGQPMAEPLFVLALGYRVVVSVAGGWLTARLAPARPMTHVGVLGAIGLLAGTVGAIATWDAGPEFGPKWYGVAVAATALPSVWLGGLLRGARA
>NZ_CP011125.1|WP_053237333.1|8750078_8750486_-|DoxX-family-protein
MDIALTQQQPVSIAPTKARLWTGRILGGLAALFLLVDGLVKFTTVEGVVEAHARLGIPMHLAPVIGALELACLALYLVPRTSLLGALAFTGFLGGAVAIHVRSETPFWFPLVIAAMLWGSLALRDARVIALLRGK
>NZ_CP011125.1|WP_053237334.1|8750499_8750928_-|glyoxalase/bleomycin-resistance/extradiol-dioxygenase-family-protein
MTIQQVDPYLSFDGDAAAAIALYERALGAQVERIMRYGDVKEFASVPGHAARVMHCVLRLGASRVLLSDAPPGMEVATASRVHVSLDFDDAAEAAAKFDALAAGGRVLYPLHDTFFGAKLGGLTDRFGISWTFHCAAAPTKA
>NZ_CP011125.1|WP_053237335.1|8751009_8752263_-|RNA-polymerase-sigma-factor
MSELAWIGTALGAARPQVVGALLRYFRDLDLAEEAYQEACLRALKNWPQNGPPRDPASWLIFVGRNAAMDVVRRRKKQRDLPDEDAISDTDDAETSLAEGLDGAQYRDDVLRLLFICVHPEIPATQQIALALRIVCGLSVPQIARAFLVSEAAMEQRITRAKARIADANVPYETPGAPERAERLSAVASVLYLMFNEGYSAPNGESASARAPLCDEAIRLARILMRLFRHEPEIMGLTSLFLLQHARSAARFDAHGEIVLLEAQDRSRWDRALIDEGLALLDKALRHRRPDPYQVQAAIAALHARASRPEDTDWAQIDRLYATLERLAPSPVITLNRAVAVSKTRGAADALAMIEPLAPKLSGYFHFFGLKGALLLQLGRDAEARTAFGQAIALARTPAEAAHIRMHLDRLQADAKG
>NZ_CP011125.1|WP_053237336.1|8752259_8752634_-|YciI-family-protein
MLYAILCYDSEEVVEAWTKDQDDAVMKRLGAVQDELRAKGRLGPVARLMPTTAATSLRKGRETIVMDGPFAETKEQLLGFYVVECESLEEAIDTAKKLGGASGSHGTFEIRPLRYFAPNGSSPT
>NZ_CP011125.1|WP_053237337.1|8752727_8753444_+|methyltransferase-domain-containing-protein
MDALFRLYEGLALLAPGDEETSRAALRRVMPLPPGARVLDVGAGTGRSARMIASAVPDAEVVAIDVHVPFLEEAMRDAPPSLRTRVESMDALSDPDESVDLIWSEGAAYVMGFESALRSWRRVVKPGAHAVVSELCWLRDERTDTARAFWAEAYPDMTDVEGARCRAENAGFAVIETIVLPERAWDAYYAPLEARCDALAADPSMNEAIESARREIALWRATRGEYGYVLFVAARVSR
>NZ_CP011125.1|WP_053237338.1|8753433_8754018_-|Uma2-family-endonuclease
MAGGAATLVRMTREQYLAAERASSEKHILWDGAVYAMAGASLAHNAIVANLVIALGTRLDRSACRPYPSDLRVRIPGSDRYVYPDATVVCGRAQLEDEHHDVLLNPTVVIEVLSAGTEAFDRGEKFAAYRTITSMQSFVLISQDQQRVEIYTRGPEGVWSFREHRGGDVTLALGNERTVALPIDALYAGVELSG

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Crispr_ID: NZ_CP011125_33

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_33

8906134-8906402

Orphan

Consensus_repeat	Method
CCGGCGAATCTCCGAGATTC	CRT

6 spacers

The CRISPR arrays of NZ_CP011125_33

>merge|NZ_CP011125|33|8906134-8906402|CRT
CCGCCGAATCTCCGACATTCGCTCGGCGATTCTAGAATCGACCGGCGAATCTCCGAGATTCACCCCCTGGATTTCGAATCCACCCGGCGAATCTCCGACATTCGCTCGGCGATTCCAGAATCGATCGGCGAATCTCCGAGATTCACCCTCTGGATTTTGAATCCACCCGGCGAATCTCCGAGATTCGGTCGGCGATTCTAGAATCGACCGGCGAATCTCCGAGATTCACCCTCTGGATTTCGAATCCACCCGGCGAATCTCCGAGATTC

>NZ_CP011125|33|3|8906134-8906402|CRT
CCGCCGAATCTCCGACATTC	GCTCGGCGATTCTAGAATCGA
CCGGCGAATCTCCGAGATTC	ACCCCCTGGATTTCGAATCCAC
CCGGCGAATCTCCGACATTC	GCTCGGCGATTCCAGAATCGA
TCGGCGAATCTCCGAGATTC	ACCCTCTGGATTTTGAATCCAC
CCGGCGAATCTCCGAGATTC	GGTCGGCGATTCTAGAATCGA
CCGGCGAATCTCCGAGATTC	ACCCTCTGGATTTCGAATCCAC
CCGGCGAATCTCCGAGATTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053237465.1\|8920738_8921548_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|378401
NZ_CP011125.1\|WP_157069943.1\|8904207_8904615_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053239090.1\|8923227_8923695_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240020
NZ_CP011125.1\|WP_053237459.1\|8906549_8909387_-\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|224182
NZ_CP011125.1\|WP_075097715.1\|8898915_8899218_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069934.1\|8897560_8898124_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237461.1\|8916329_8917604_-\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|179997
NZ_CP011125.1\|WP_157069951.1\|8922385_8923231_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069948.1\|8921547_8922441_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|184875
NZ_CP011125.1\|WP_157069939.1\|8902509_8902992_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069945.1\|8919216_8919561_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237464.1\|8919598_8920606_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378890
NZ_CP011125.1\|WP_053237451.1\|8899267_8899504_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381118
NZ_CP011125.1\|WP_053237462.1\|8917603_8919106_-\|glycogen-synthase	unknown	unknown	gnl\|CDD\|340822
NZ_CP011125.1\|WP_157069936.1\|8900332_8902369_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274730
NZ_CP011125.1\|WP_157069941.1\|8903571_8904003_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237460.1\|8909383_8915536_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|365868
NZ_CP011125.1\|WP_053237455.1\|8903009_8903504_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237458.1\|8905132_8905978_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069932.1\|8895630_8897172_+\|response-regulator	unknown	unknown	gnl\|CDD\|274362

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053237465.1\|8920738_8921548_+\|metal-dependent-hydrolase	gnl\|CDD\|378401	pfam10118, Metal_hydrol, Predicted metal-dependent hydrolase. Members of this family of proteins comprise various bacterial transition metal-dependent hydrolases.	2.07805e-91
NZ_CP011125.1\|WP_053239090.1\|8923227_8923695_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240020	cd04662, Nudix_Hydrolase_5, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.4924e-52
NZ_CP011125.1\|WP_053237459.1\|8906549_8909387_-\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|224182	COG1262, COG1262, Uncharacterized conserved protein [Function unknown].	7.40274e-06
NZ_CP011125.1\|WP_053237451.1\|8899267_8899504_+\|hypothetical-protein	gnl\|CDD\|381118	cd17580, REC_2_DhkD-like, second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains. Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.02595e-05
NZ_CP011125.1\|WP_157069936.1\|8900332_8902369_-\|hypothetical-protein	gnl\|CDD\|274730	TIGR03696, tRNA_nuclease_WapA, RHS repeat-associated core domain. This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.	4.2523e-15
NZ_CP011125.1\|WP_053237462.1\|8917603_8919106_-\|glycogen-synthase	gnl\|CDD\|340822	cd03791, GT5_Glycogen_synthase_DULL1-like, Glycogen synthase GlgA and similar proteins. This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.	5.39169e-179
NZ_CP011125.1\|WP_053237460.1\|8909383_8915536_-\|VWA-domain-containing-protein	gnl\|CDD\|365868	pfam00092, VWA, von Willebrand factor type A domain.	4.99656e-11
NZ_CP011125.1\|WP_157069948.1\|8921547_8922441_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	6.75091e-28
NZ_CP011125.1\|WP_053237461.1\|8916329_8917604_-\|NTP-transferase-domain-containing-protein	gnl\|CDD\|179997	PRK05293, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	2.62058e-178
NZ_CP011125.1\|WP_157069932.1\|8895630_8897172_+\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	1.57401e-57
NZ_CP011125.1\|WP_053237464.1\|8919598_8920606_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	4.30454e-33

>NZ_CP011125.1|WP_053237458.1|8905132_8905978_-|hypothetical-protein
MPVRPDSHPDAPSLKAALDSKRDLLERMPEPEIFRTHRLDAATAAGVVIGSLPRIAQHRDAIAAQFGREGAGFLDDLPIVARATLQANVELTASDAMSDLADMAADVAEEHKLVFTDAEALANRKLLDRSRVETGRPVQGYRTVATSTLVIVSLFREHWSAVRNKTPLTREDLDRVEKKAELLLQRLDEREQGSTRLPAAELRTRAISLLVSTYGEVRRMITYVRWWDEDADTIAPSLWSGRRRGSRNEVVVEPTDPTEPETPVTPIPTPGPMNGDGPFTS
>NZ_CP011125.1|WP_157069943.1|8904207_8904615_-|hypothetical-protein
MTRFDEVFMRQAKFPTRRADGSVSVAGRFNFGGQVAADAAAAKVRSWIAEREAETIELTEDLASAPYIVVRDDSTFDVVFEGRPGQPRWKDWMVALTRELASTVSNVRFDCFYDLVGDVRHPGSGIPGSGTLPQA
>NZ_CP011125.1|WP_157069941.1|8903571_8904003_-|hypothetical-protein
MYADPSGAPHAVTQAGPNGYSYDARGRQVERSGPQVREGFQRIDSYTAFDLPVSVTVGLGEASRTGYLHTDPLGSVVLVTDETGAPRCESTDAFDPTPASSIRSSTVQLRLRLRPTAPTFSSGGKDAAVPLASMSSSSEKKAW
>NZ_CP011125.1|WP_053237455.1|8903009_8903504_-|hypothetical-protein
MVTLEERFVLHTTSADIEFDMTTASFAERFLDYHVTIRALDDARAAGVCFPTRVPCSTYQGSFRSFRRLFEEYLSGGKDTDGVPDEASEIFLAMELDFFFYFRGRLGCWPDGRRVRLVFMLIMPSSPPNERDYAGIEGSVAVDAVRGLFEFMSEWETVLRRTAS
>NZ_CP011125.1|WP_157069939.1|8902509_8902992_-|hypothetical-protein
MPTNPRQTVANAFSLVTKGGCVEFDMSNARLIDGMLTCLVSLRPTEAAARAGLRLPHDIACSIRPETFRVFRTSFEAYLRETVDSDGALVRNSEEFVPEQQNFWFAIHGGGVDEDGTGEVALLFMLSAGQMYVGVRGDVQIVAIRELFDFMDGWTAKLGG
>NZ_CP011125.1|WP_157069936.1|8900332_8902369_-|hypothetical-protein
MGANRGFLSSETHDQPGLPEMVVTSSYDSFGRPLQLGYPGEAGAFAVTHEYDSFGHLNRLRDSTGTLLWESLESYQGYRRAGETFGNGVESSVSFEPLTGRIQRMSTTSAAGVARDVTYAYDLDGRRASEIDGLTPANSRAFVHDVLGRLTDVTNLDGTVTHESTRYDALGNITFRTGIGTYDSNDPSGSPHAVSQAGGNSYSYDARGRQQERSGPQVSGGFQRIDEYTAFDLPTTIVVGAGEAAETVEMRYDASDRIAARLSTGTDIRYIGRLYSREETSAGVEHRFRVYADGHQVVEVTRHTGGVGGTTESRQFLHADALGSIVLVTDDNGHEVDERSYASFGDAGSVTGPEAGYTGHRHDDELGLIDMIGRVYDPVIGRFLTPDPITAMPTWTQSLNRYAYVYNSPFVDRSDWLQRGERHEHGWWACHASAAPRCRVARIRRTGEPDIRRPSVAGPIGRHVAAAESLRRRDQLERRADRDRRCRGRTIAFHRLGNASRPDCPSRRGYRGRSHGVCRPAPDRPRECTCFRDWRAHRLDWWPGIRRCRDRERARRHRGIGGRWHRRGCSERGSQSRTRGCWGRRGCGARDRWSGRCGRARARRRDRARSHRPHERRRRRFREPARVLRARRRSPVRTGESGRAATDSWSEREECSPHRGHRPGAESRRARRTPTSRV
>NZ_CP011125.1|WP_053237451.1|8899267_8899504_+|hypothetical-protein
MSAEDRAGLQVIDRKARGRAVQRDPAIAISGLVREEDARASSEGGVDRHVGKPLDPIELAREIARMIGPPSDVTRAPS
>NZ_CP011125.1|WP_075097715.1|8898915_8899218_-|hypothetical-protein
MRPEALDAIALGRMPAEPDATDAELRRWQDTIQRIPEPVSLQEARALSASFGPDDCFGLAWALLHKIETCGMQVVVDEPEPSDEWRHRLWRRWQNQLGIP
>NZ_CP011125.1|WP_157069934.1|8897560_8898124_-|hypothetical-protein
MDYLAHSCVIADGVVRCRGNADGGRLGPGCSSSHCDEWVDVPIPDRVIAVATTIQGGCALAVNRTELHCWGGVVGDTSLCHPDSSRIMPPADAIRRHRLPGSVEALRSVGVNVCAVLTDGDVHCLTTLGVTIPSSVLVDREPRRVLGEVADIGQTSLARTCAILRSGEVRCNASLDDVGFDLAAAID
>NZ_CP011125.1|WP_157069932.1|8895630_8897172_+|response-regulator
MALLHVWLRPWLGSTASLMLFLLAVYVSASVAGMLGGSIAAVLGVLVGSVFFMGRPGELGPLASGDQVRVVFFLAVAIAMSATSELLLRTRRRLQREVDARSDALAEREKLLLRERDARANAESMARLRDEFVGTVSHELRTPVNAILGFAVLLRQRASVDPKIVRGLEVIERNARAQARLIDDMLDLGRILGGKMALVPERLDLRVPIRDALESVRMSARAKHLVLEIDLGEEAVPVMGDAGRLQQVAWNLLSNALKFTPSGGRVRVALRREDERAVLDVIDTGEGIDPAFLPHVFDRFRQQDASSTRVHGGMGIGLAITRQLIELHGGRVRAESAGRGRGARFEVSLPIAEPGAQPHAEEAMPTRPSAVTPVPLAHGLLEGARVLLVEDDPDSREAVREGLRSSGAMVDAADAAEPALALLDRGRYDVLVSDIGMPGHDGWWLMREVRRAAAQYSRIPAIAISGFVREEDARASSEAGFDRHVGKPLDPIELAREIARMIGRPSDVTSAPS
>NZ_CP011125.1|WP_053237459.1|8906549_8909387_-|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MSRFVSSAQRLALLVVLSSCTVEPYCLVCPDVDGGEPLDGGTDAGSDARVAPRDASADVIVVPDGACIDFELCNERDDDCDGHTDEGIDTESNPDHCGGCDMPCPVYPHAFAVCEAGECSIGACDVGYLDLDPAQPGCEYYCIPTVTDGTDEICDFNDDDCDGAIDEDIDFANDPENCGFTSSGAGRCGNHCRGSRAAGSCSAGVCTLGACDPGYYDIDGSATNGCEYQCTPADPPVEVCNLLDDDCDGTVDDGEPGAGVACGSDVGACGAAAGVTICRAGEIVCTGEPAPAAETCNTVDDDCDGRVDENNPEGGRVCGISTGACEVGTQQCVGGALVCMGQVEATAEICNTIDDDCDGAVDDGNPGGGAACGPTAGACEAGVVTCTRGALVCTGGVGPSPELCNNVDDDCDGNVDEGDPEGGQLCGSDVGRCAPGVQHCRSGSLVCEGAITATTETCDGVDQDCDSNVDEGNPGGGAACGETAGACEAGTVQCRGGTLTCEGAIGPTVELCNGTNDDCDAMTDEGFALMTDINNCGACGRVCSFPNATPRCNAGTCAIAACRPGFVDLDPTRPGCEYACSFAGNEACNGRDDDCDGRTDEGLTAPSAFCNPNGVCNGTAATCGGARGWECVYPATYQQTEQRCDSLDNDCDGSIDEAFPLVGDQCSNGSGTCRRVGTYVCAASGTAVQCNAAAAGTPGDESCNGADDDCDGEVDETGVNDPGTPWRDAIDASAIPTVTYTSGGRTIRVMRYEASRPDATSTSAGSLSTLACSAPNVRPWTSVTWAEAEAACCALNASGTCTSPTSGWHLCGAEDWETACEGPAGSCDWSYAATCSATQPVACNGMEYDSNTSLAGDQDALATTGSPTFSSCYTDWAAAGRVYDMSGNVREWTSTSAGTSGGVPLYQVRGGSYQSIEEGRTCDFDFTVAQRTFRAPTTGFRCCMY
>NZ_CP011125.1|WP_053237460.1|8909383_8915536_-|VWA-domain-containing-protein
MHVGHAYGEGIAALMVSKSIPESTVAVIDPESGTSSGASTGTDVRIAPGDVILFRINYFGMPDRVARGINAYITEFVPPNTEVVGVRLIDPTTLTAYPGGRTIAPNHPGLALDRCTSGGSCGTYTLPCTGGAGCSGGTRSVPEGALSQLYGDTGFFYSTDARTQRTPANAFLTYFNGQSMAGRPPTFAASISPILGLDGVTTFFGHTPWDVDQVYAFGIANSDGNRSGNQGNGDTPFQYGSPVAGPQTHYLYEATDLSVGGADPPTDVVFNHVVGPWQRIRYAGARIGTGTTATYTASDTRRSIDASATGFDVRPANPLPAATNAVRAAIGELRAGEAGILEIALRVIDTPLDPVMMRDANCAESFGGGPSSSNAGQDNPWGFVIPSPGCVFLNNQFDLTPDRMLTDNGERITYTLHGMNLSTLPQTNVVVTADYDSSRGALVPGSATGAPSSAMCGTRPCLRWVLGTLDPGEEYTFTFQYDVSGTGQISLVSYANYTSTQLPAPGFTTQAVTLSRPTPVLRASFTQPLTAQAAGSNVVLSGTLQNWGTQAASLDPAQMLLPAGWTVVSGPTLGTTSLGPRTSITTPTSTPISVTLRAPAGTAAGLYDLDFKLFWSASNYGGSFEAFFPTAVRVPIGQPRSDRPVIDCSRVLSSATTIVGTHTESNASTVVRVFFNNIERGSDASTAGGAWDVGTFGPGSTFGALYGGLEVTATAQAPGELVSLPSEPCFVTHVPGCSDGLDNDGDGDVDFPGDSGCSGPGDNDERDVQCSDGVDNDGDGRVDFPADPECNGPDDGTEGGAPACSNGVDDDGDGRVDYPADPDCSSSSDRDEVTRRACSDGLDNDGDGRIDFGLGATNDEGCHSANDTSEGPFVYAPGDVRPRILLVFDTSGSMNWHTCADQFTGGDGSGECLGGDVACATCGASGCGNGIADDSRIARARAGVSDVVAAFGDVEMGLMRFRQRATSFACPSANATAASGGWAGSGAVCGEYAAGDLLVGFSPENEYSILEWLDGSDNYGGTAPAGLDLELRGSGTTPLAGSLASAQAYLADVRTDDPRSSCRPYEVILLTDGAETCGGDPIDAATDLRTAGFPVNVIGFANSPDASAQLNAIASNGGTGSAIFVDDSAALSAAIADIVNGSIRTELCNGGDDDCDTLVDEGFVLYCNRPGGVTSPTLCTDPGETQCNGVDDNCDGRIDEGLRNRCGACGAEPPEVCNGVDDDCDGVADENNVCAGCRPEAELCDDVDNDCDGRTDEGLARVCGTDVGACTVGQEVCTAGAWGTCSGTGPATETCDNVDNDCDGVIDGLTRPCGTSVGVCRPGTETCTASVWGACVGAVGASPEICNTLDDDCDGVVDDGNPGGGGACGTALGECNPGALSCVAGALVCSGGTGPTPETCDNQDDDCDGRVDEELPTGASCGACGAGLMRCVGGTMTCTGDRAPGTEICNGADDDCDTRIDEGNPGGGVTCGTSTGACEPGRTQCTGGAIVCTGGTGPATESCNTIDDDCDNLVDEGNPGGGAECGGSDAGECERGTEVCVGGALVCVGESGPQPERCDGLDNDCNGSVDEGNPGGGAACGDDTGECTAGTTMCQGGTLVCSGGRGPVEEVCNDLDDDCDGVVDDGLSVGAPCGEGTGECTPGRLTCVGGEIVCEGGNGPINESCNNLDDDCDTRIDEEVPSAVCGETEGVCEPGTLTCIGGRQVCTGGTPRGREVCDCDDDDCDMMVDEDPDGTLCPPGSACVDCACALPCADSEFARCPAGRVPQTNDEGMCFCVAPRCDDTACAGETVMDGDEVFCAPGMEAEGIPSCACHNNRCTYACEDVDCSAEGLRCEPFSGTCQVDDCRSFPCPAGEICDRTAPDPVCVPDPCATAGCTAEQACRAGVCETSCAEVSCEDGERCTSGECLVNPCADVSCGGERVCDPTTGECTTNLCGDVVCSSGDVCDPLTGLCRRDRCLDLQCPEGQRCSGGECELVVVPRLDGGPPLDDGGSDVDAGPDGGDGTVRVLAAGGGGCLCTAAGTGESSRAPWAMAMLAALGLVLVARRRVR
>NZ_CP011125.1|WP_053237461.1|8916329_8917604_-|NTP-transferase-domain-containing-protein
MKTVAVILAGGEGSRLGVLTAKRTKPAVPFGGKFRIIDFALSNCVNSGLFDVMIVAQYRPHSLIEHIGAGGPWELDRERTGGVRIYSPYKSREAGSWFVGTADAVQQNFLFVKDRRPDLVVILSGDHIYRMNYNDLIAKHLERRADVTLATMEVPDHEKSRFGIVQLDDDERVTSFVEKPKDPIPGLGSMGIYVFNYGVLDRVLLEDSRMPDSNHDFGKDILPRMIARGERVFSWKYAGYWRDVGTIESYWEAHMDLIGEPPLYDLNDLGWLIHTRSENRPPARLAKGADVSDSLITHGCAIATDAHIERSILSAGVRVEPGAVVRESVLLTDCVIERGAVVERAILDKRARVGQGARVGAMPQGDDEPGSRRFAVLGKNAVIPAGFVVGAGAEVGPDVIPSDLGSSPLPEGAAVFTKRRPHEV
>NZ_CP011125.1|WP_053237462.1|8917603_8919106_-|glycogen-synthase
MKILFLTAEAAPFTKVGGLGDVAGALPAALRAVPGAGLDVRVVTPLHGGARARITTPLERVARVSVPHPSGPLGAEILATTYDGVPFYFVHAPGLFDDSIAVYHQDTGWDGHRYAFFCLAALELARVIDFVPDVLHANDWHTAPSIPALHRARFSDPKLGRARTALTVHNLPYVGWGAGPAMRAFGLVPGELPRVAPEGREMPLPIGLSLADRITTVSPGYAREILEPEFGAGLDALLRARKDALVGILNGIDTELYDPKTDAALPQRYDATTALAARAVNKRALRRELGLVHEQGSVDEPLPLLAVVSRLTGQKGIDLVPDAIRALARDHAFQCVILGTGDHALEEQLLRLAGELGDRVRVRVAFDEALSRRIYAGADMLMLPSRYEPCGLAQMIAMRYGCVPVARDTGGLSDTVRDLDLHDAPTGFLFPVASSRSLAFGLRRALATFAAVSPRTGEHCAREGRFAMLQQNGMREDFSWSRAALAYAHTYRELVTGETR
>NZ_CP011125.1|WP_157069945.1|8919216_8919561_+|hypothetical-protein
MTKRTTAPAIVLVALALSACGQSAEEAACNDTVQVFGDAIVRCGLDDGLSRDALERQIESTVTMTQGCGRVVSIRDEAELREECLPALETLACSSLEAGTLPASCRAQIEVEVR
>NZ_CP011125.1|WP_053237464.1|8919598_8920606_-|AraC-family-transcriptional-regulator
MHAPDAHTIPAIHALHLADVVERWGIDVDALLAGSGWTPDALAQPDARLTLADVERLVERARKLTGEPGLGFHVGLQMRIASHGFLGLAAMAAPTLGDAAQVAVRFAPTRTTALSLRLETGPEGAALVMLEHADLGSARDAVVLALTVGIVQLARALTGADAAYQVELAFDEPSYYRRFAHLLRPARFGCPVHRITFPAAALAARLVTADPAALRLTLEQCERELAELRAGDPFSQRVARVLPRASGGFLTIEEVAKALHVSTRTLKRRLAEEGTSFRDLLEDARRARALVLLRDELGLDEIAARLGYSDAANFSRAFRRWTGVTPGAWRTREPK
>NZ_CP011125.1|WP_053237465.1|8920738_8921548_+|metal-dependent-hydrolase
MNGTQTLEVRNLTFATGADVPRHWHGGRRSVTRFLDNLSIFFPEGERFFVMSVQAHRHVVENDPVLRKLVRDFCAQEGIHGREHRRYNDMLRAQGLPVDEMEQSVVRILKRAKRTLPPRTQLAVTAALEHFTALMGHLILARPALLEGAHPEMVALWRWHAAEENEHKAVAFDVYRAAGGNYAERSVIMLAATAVFWAKVLEFQTRMMAEDGDALSAREWIALVRFLFVEPGGLQEVWRLWADWFRPGFHPNDIDSAGAIAAWQASAGA
>NZ_CP011125.1|WP_157069948.1|8921547_8922441_+|alpha/beta-fold-hydrolase
MGLLSLVEGLSHVALRARGLRGRMIDTAVGRVHAYVGRGHGALPPVVMVHGIGSAAAPFAPVIARVQEHVRAVIAPELPGHGWSAPPRGRLAPDTLFEVMGAVIDRLIDEPAVVVGNSLGGAVALDYARTRPEKVRALVLLSPAGARMSEDELEAVRRVFHLRSTADAIAFVERVYHRAPPGASWVAGDVRRQMGRAVVRELLANVRSDHGFDPDALRGLTMPVTLMWGRSERVLPASGLAYFRAHLPAHARVEEPEGVGHCPHLDRPGLVARRIVEAAISGSALEGARAHAGDPRA
>NZ_CP011125.1|WP_157069951.1|8922385_8923231_-|hypothetical-protein
MTRQPTIPSSSSSDVLVLVLLLASCAPTPPPHEPDVLATTGEELAAIPDTDVPDAIEPPPPTPCDAHPPSPTTLEPLGQRGILVLDASFPRELGTCLSPALVLREGAIECEPGSTRCRVGDRAILLAREHDDRCEPYALIRYPDTTPTTEPDDVLAALAHRDEACALHDRIALQDPSLYDATLRARRIQAGPRTALVAECLRDADAQTFAADARARFARVPLRCAGLRCESAAAADDAAAPAHSLVFANRLSGPLRFDAVAWVLTPEDHPRALELLRERCR
>NZ_CP011125.1|WP_053239090.1|8923227_8923695_-|NUDIX-domain-containing-protein
MVLLRRGARGIEMLVVHPGGPFFAKKHEGAWSIPKGMIEEGEDPLAAAQREVVEELGVTPPAPPYVALGDVRLKSGKRVHAWAARADFDPSRIVSNEFELEWPPRSGRLQRFPEVDRASWVDLETAKRLTSPALAPLFERAVSKETLDIVFGDPP

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Crispr_ID: NZ_CP011125_34

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_34

8911762-8911991

Orphan

Consensus_repeat	Method
GGCCCTCGTCGGTGCGGCCGTCGCAGTCGTCGTCGACGCCGTTGCACTCCGCCTCGCCG	PILER-CR
GCCGTCGCAGTCGTCGTCGACGCCGTTGCA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP011125_34

>merge|NZ_CP011125|34|8911762-8911991|PILER-CR,CRISPRCasFinder
GGCCCTCGTCGGTGCGGCCGTCGCAGTCGTTGTCGACGTCGTCGCAGAGCTCCGCCTCGGGGCGGCAGCCCGCGCAGACGTTGTTCTCGTCGGCGACGCCGTCGCAGTCGTCGTCGACGCCGTTGCAGACCTCGGGCGGCTCCGCGCCGCACGCGCCGCAGCGGTTGCGCAGGCCCTCGTCGATGCGGCCGTCGCAGTTGTCGTCGACGCCGTTGCACTGCGTCTCGCCG

>NZ_CP011125|34|5|8911762-8911991|PILER-CR
GGCCCTCGTCGGTGCGGCCGTCGCAGTCGTTGTCGACGTCGTCGCAGAGCTCCGCCTCGGGG	CGGCAGCCCGCGCAGACGTTGTT
CTCGTCGGCGACGCCGTCGCAGTCGTCGTCGACGCCGTTGCAGACCTCGGGCGGCTCCGCGC	CGCACGCGCCGCAGCGGTTGCGCAGGCCCTCGTCGATGCGGCCG
TCGCAGTTGTCGTCGACGCCGTTGCACTGCGTCTCGCCG

>NZ_CP011125|34|28|8911778-8911867|CRISPRCasFinder
GCCGTCGCAGTCGTTGTCGACGTCGTCGCA	GAGCTCCGCCTCGGGGCGGCAGCCCGCGCA
GACGTTGTTCTCGTCGGCGACGCCGTCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053237465.1\|8920738_8921548_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|378401
NZ_CP011125.1\|WP_157069943.1\|8904207_8904615_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053239090.1\|8923227_8923695_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240020
NZ_CP011125.1\|WP_053237459.1\|8906549_8909387_-\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|224182
NZ_CP011125.1\|WP_169791684.1\|8924483_8925023_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_075097715.1\|8898915_8899218_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069934.1\|8897560_8898124_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237461.1\|8916329_8917604_-\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|179997
NZ_CP011125.1\|WP_157069951.1\|8922385_8923231_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069948.1\|8921547_8922441_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|184875
NZ_CP011125.1\|WP_157069939.1\|8902509_8902992_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237468.1\|8924145_8924487_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_CP011125.1\|WP_157069945.1\|8919216_8919561_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237464.1\|8919598_8920606_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378890
NZ_CP011125.1\|WP_053237451.1\|8899267_8899504_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381118
NZ_CP011125.1\|WP_053237462.1\|8917603_8919106_-\|glycogen-synthase	unknown	unknown	gnl\|CDD\|340822
NZ_CP011125.1\|WP_157069936.1\|8900332_8902369_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274730
NZ_CP011125.1\|WP_157069941.1\|8903571_8904003_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237455.1\|8903009_8903504_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237458.1\|8905132_8905978_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053237465.1\|8920738_8921548_+\|metal-dependent-hydrolase	gnl\|CDD\|378401	pfam10118, Metal_hydrol, Predicted metal-dependent hydrolase. Members of this family of proteins comprise various bacterial transition metal-dependent hydrolases.	2.07805e-91
NZ_CP011125.1\|WP_053239090.1\|8923227_8923695_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240020	cd04662, Nudix_Hydrolase_5, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.4924e-52
NZ_CP011125.1\|WP_053237459.1\|8906549_8909387_-\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|224182	COG1262, COG1262, Uncharacterized conserved protein [Function unknown].	7.40274e-06
NZ_CP011125.1\|WP_053237451.1\|8899267_8899504_+\|hypothetical-protein	gnl\|CDD\|381118	cd17580, REC_2_DhkD-like, second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains. Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.02595e-05
NZ_CP011125.1\|WP_157069936.1\|8900332_8902369_-\|hypothetical-protein	gnl\|CDD\|274730	TIGR03696, tRNA_nuclease_WapA, RHS repeat-associated core domain. This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.	4.2523e-15
NZ_CP011125.1\|WP_053237462.1\|8917603_8919106_-\|glycogen-synthase	gnl\|CDD\|340822	cd03791, GT5_Glycogen_synthase_DULL1-like, Glycogen synthase GlgA and similar proteins. This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.	5.39169e-179
NZ_CP011125.1\|WP_053237461.1\|8916329_8917604_-\|NTP-transferase-domain-containing-protein	gnl\|CDD\|179997	PRK05293, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	2.62058e-178
NZ_CP011125.1\|WP_053237468.1\|8924145_8924487_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	4.1973e-19
NZ_CP011125.1\|WP_157069948.1\|8921547_8922441_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	6.75091e-28
NZ_CP011125.1\|WP_053237464.1\|8919598_8920606_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	4.30454e-33

>NZ_CP011125.1|WP_053237459.1|8906549_8909387_-|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MSRFVSSAQRLALLVVLSSCTVEPYCLVCPDVDGGEPLDGGTDAGSDARVAPRDASADVIVVPDGACIDFELCNERDDDCDGHTDEGIDTESNPDHCGGCDMPCPVYPHAFAVCEAGECSIGACDVGYLDLDPAQPGCEYYCIPTVTDGTDEICDFNDDDCDGAIDEDIDFANDPENCGFTSSGAGRCGNHCRGSRAAGSCSAGVCTLGACDPGYYDIDGSATNGCEYQCTPADPPVEVCNLLDDDCDGTVDDGEPGAGVACGSDVGACGAAAGVTICRAGEIVCTGEPAPAAETCNTVDDDCDGRVDENNPEGGRVCGISTGACEVGTQQCVGGALVCMGQVEATAEICNTIDDDCDGAVDDGNPGGGAACGPTAGACEAGVVTCTRGALVCTGGVGPSPELCNNVDDDCDGNVDEGDPEGGQLCGSDVGRCAPGVQHCRSGSLVCEGAITATTETCDGVDQDCDSNVDEGNPGGGAACGETAGACEAGTVQCRGGTLTCEGAIGPTVELCNGTNDDCDAMTDEGFALMTDINNCGACGRVCSFPNATPRCNAGTCAIAACRPGFVDLDPTRPGCEYACSFAGNEACNGRDDDCDGRTDEGLTAPSAFCNPNGVCNGTAATCGGARGWECVYPATYQQTEQRCDSLDNDCDGSIDEAFPLVGDQCSNGSGTCRRVGTYVCAASGTAVQCNAAAAGTPGDESCNGADDDCDGEVDETGVNDPGTPWRDAIDASAIPTVTYTSGGRTIRVMRYEASRPDATSTSAGSLSTLACSAPNVRPWTSVTWAEAEAACCALNASGTCTSPTSGWHLCGAEDWETACEGPAGSCDWSYAATCSATQPVACNGMEYDSNTSLAGDQDALATTGSPTFSSCYTDWAAAGRVYDMSGNVREWTSTSAGTSGGVPLYQVRGGSYQSIEEGRTCDFDFTVAQRTFRAPTTGFRCCMY
>NZ_CP011125.1|WP_053237458.1|8905132_8905978_-|hypothetical-protein
MPVRPDSHPDAPSLKAALDSKRDLLERMPEPEIFRTHRLDAATAAGVVIGSLPRIAQHRDAIAAQFGREGAGFLDDLPIVARATLQANVELTASDAMSDLADMAADVAEEHKLVFTDAEALANRKLLDRSRVETGRPVQGYRTVATSTLVIVSLFREHWSAVRNKTPLTREDLDRVEKKAELLLQRLDEREQGSTRLPAAELRTRAISLLVSTYGEVRRMITYVRWWDEDADTIAPSLWSGRRRGSRNEVVVEPTDPTEPETPVTPIPTPGPMNGDGPFTS
>NZ_CP011125.1|WP_157069943.1|8904207_8904615_-|hypothetical-protein
MTRFDEVFMRQAKFPTRRADGSVSVAGRFNFGGQVAADAAAAKVRSWIAEREAETIELTEDLASAPYIVVRDDSTFDVVFEGRPGQPRWKDWMVALTRELASTVSNVRFDCFYDLVGDVRHPGSGIPGSGTLPQA
>NZ_CP011125.1|WP_157069941.1|8903571_8904003_-|hypothetical-protein
MYADPSGAPHAVTQAGPNGYSYDARGRQVERSGPQVREGFQRIDSYTAFDLPVSVTVGLGEASRTGYLHTDPLGSVVLVTDETGAPRCESTDAFDPTPASSIRSSTVQLRLRLRPTAPTFSSGGKDAAVPLASMSSSSEKKAW
>NZ_CP011125.1|WP_053237455.1|8903009_8903504_-|hypothetical-protein
MVTLEERFVLHTTSADIEFDMTTASFAERFLDYHVTIRALDDARAAGVCFPTRVPCSTYQGSFRSFRRLFEEYLSGGKDTDGVPDEASEIFLAMELDFFFYFRGRLGCWPDGRRVRLVFMLIMPSSPPNERDYAGIEGSVAVDAVRGLFEFMSEWETVLRRTAS
>NZ_CP011125.1|WP_157069939.1|8902509_8902992_-|hypothetical-protein
MPTNPRQTVANAFSLVTKGGCVEFDMSNARLIDGMLTCLVSLRPTEAAARAGLRLPHDIACSIRPETFRVFRTSFEAYLRETVDSDGALVRNSEEFVPEQQNFWFAIHGGGVDEDGTGEVALLFMLSAGQMYVGVRGDVQIVAIRELFDFMDGWTAKLGG
>NZ_CP011125.1|WP_157069936.1|8900332_8902369_-|hypothetical-protein
MGANRGFLSSETHDQPGLPEMVVTSSYDSFGRPLQLGYPGEAGAFAVTHEYDSFGHLNRLRDSTGTLLWESLESYQGYRRAGETFGNGVESSVSFEPLTGRIQRMSTTSAAGVARDVTYAYDLDGRRASEIDGLTPANSRAFVHDVLGRLTDVTNLDGTVTHESTRYDALGNITFRTGIGTYDSNDPSGSPHAVSQAGGNSYSYDARGRQQERSGPQVSGGFQRIDEYTAFDLPTTIVVGAGEAAETVEMRYDASDRIAARLSTGTDIRYIGRLYSREETSAGVEHRFRVYADGHQVVEVTRHTGGVGGTTESRQFLHADALGSIVLVTDDNGHEVDERSYASFGDAGSVTGPEAGYTGHRHDDELGLIDMIGRVYDPVIGRFLTPDPITAMPTWTQSLNRYAYVYNSPFVDRSDWLQRGERHEHGWWACHASAAPRCRVARIRRTGEPDIRRPSVAGPIGRHVAAAESLRRRDQLERRADRDRRCRGRTIAFHRLGNASRPDCPSRRGYRGRSHGVCRPAPDRPRECTCFRDWRAHRLDWWPGIRRCRDRERARRHRGIGGRWHRRGCSERGSQSRTRGCWGRRGCGARDRWSGRCGRARARRRDRARSHRPHERRRRRFREPARVLRARRRSPVRTGESGRAATDSWSEREECSPHRGHRPGAESRRARRTPTSRV
>NZ_CP011125.1|WP_053237451.1|8899267_8899504_+|hypothetical-protein
MSAEDRAGLQVIDRKARGRAVQRDPAIAISGLVREEDARASSEGGVDRHVGKPLDPIELAREIARMIGPPSDVTRAPS
>NZ_CP011125.1|WP_075097715.1|8898915_8899218_-|hypothetical-protein
MRPEALDAIALGRMPAEPDATDAELRRWQDTIQRIPEPVSLQEARALSASFGPDDCFGLAWALLHKIETCGMQVVVDEPEPSDEWRHRLWRRWQNQLGIP
>NZ_CP011125.1|WP_157069934.1|8897560_8898124_-|hypothetical-protein
MDYLAHSCVIADGVVRCRGNADGGRLGPGCSSSHCDEWVDVPIPDRVIAVATTIQGGCALAVNRTELHCWGGVVGDTSLCHPDSSRIMPPADAIRRHRLPGSVEALRSVGVNVCAVLTDGDVHCLTTLGVTIPSSVLVDREPRRVLGEVADIGQTSLARTCAILRSGEVRCNASLDDVGFDLAAAID
>NZ_CP011125.1|WP_053237461.1|8916329_8917604_-|NTP-transferase-domain-containing-protein
MKTVAVILAGGEGSRLGVLTAKRTKPAVPFGGKFRIIDFALSNCVNSGLFDVMIVAQYRPHSLIEHIGAGGPWELDRERTGGVRIYSPYKSREAGSWFVGTADAVQQNFLFVKDRRPDLVVILSGDHIYRMNYNDLIAKHLERRADVTLATMEVPDHEKSRFGIVQLDDDERVTSFVEKPKDPIPGLGSMGIYVFNYGVLDRVLLEDSRMPDSNHDFGKDILPRMIARGERVFSWKYAGYWRDVGTIESYWEAHMDLIGEPPLYDLNDLGWLIHTRSENRPPARLAKGADVSDSLITHGCAIATDAHIERSILSAGVRVEPGAVVRESVLLTDCVIERGAVVERAILDKRARVGQGARVGAMPQGDDEPGSRRFAVLGKNAVIPAGFVVGAGAEVGPDVIPSDLGSSPLPEGAAVFTKRRPHEV
>NZ_CP011125.1|WP_053237462.1|8917603_8919106_-|glycogen-synthase
MKILFLTAEAAPFTKVGGLGDVAGALPAALRAVPGAGLDVRVVTPLHGGARARITTPLERVARVSVPHPSGPLGAEILATTYDGVPFYFVHAPGLFDDSIAVYHQDTGWDGHRYAFFCLAALELARVIDFVPDVLHANDWHTAPSIPALHRARFSDPKLGRARTALTVHNLPYVGWGAGPAMRAFGLVPGELPRVAPEGREMPLPIGLSLADRITTVSPGYAREILEPEFGAGLDALLRARKDALVGILNGIDTELYDPKTDAALPQRYDATTALAARAVNKRALRRELGLVHEQGSVDEPLPLLAVVSRLTGQKGIDLVPDAIRALARDHAFQCVILGTGDHALEEQLLRLAGELGDRVRVRVAFDEALSRRIYAGADMLMLPSRYEPCGLAQMIAMRYGCVPVARDTGGLSDTVRDLDLHDAPTGFLFPVASSRSLAFGLRRALATFAAVSPRTGEHCAREGRFAMLQQNGMREDFSWSRAALAYAHTYRELVTGETR
>NZ_CP011125.1|WP_157069945.1|8919216_8919561_+|hypothetical-protein
MTKRTTAPAIVLVALALSACGQSAEEAACNDTVQVFGDAIVRCGLDDGLSRDALERQIESTVTMTQGCGRVVSIRDEAELREECLPALETLACSSLEAGTLPASCRAQIEVEVR
>NZ_CP011125.1|WP_053237464.1|8919598_8920606_-|AraC-family-transcriptional-regulator
MHAPDAHTIPAIHALHLADVVERWGIDVDALLAGSGWTPDALAQPDARLTLADVERLVERARKLTGEPGLGFHVGLQMRIASHGFLGLAAMAAPTLGDAAQVAVRFAPTRTTALSLRLETGPEGAALVMLEHADLGSARDAVVLALTVGIVQLARALTGADAAYQVELAFDEPSYYRRFAHLLRPARFGCPVHRITFPAAALAARLVTADPAALRLTLEQCERELAELRAGDPFSQRVARVLPRASGGFLTIEEVAKALHVSTRTLKRRLAEEGTSFRDLLEDARRARALVLLRDELGLDEIAARLGYSDAANFSRAFRRWTGVTPGAWRTREPK
>NZ_CP011125.1|WP_053237465.1|8920738_8921548_+|metal-dependent-hydrolase
MNGTQTLEVRNLTFATGADVPRHWHGGRRSVTRFLDNLSIFFPEGERFFVMSVQAHRHVVENDPVLRKLVRDFCAQEGIHGREHRRYNDMLRAQGLPVDEMEQSVVRILKRAKRTLPPRTQLAVTAALEHFTALMGHLILARPALLEGAHPEMVALWRWHAAEENEHKAVAFDVYRAAGGNYAERSVIMLAATAVFWAKVLEFQTRMMAEDGDALSAREWIALVRFLFVEPGGLQEVWRLWADWFRPGFHPNDIDSAGAIAAWQASAGA
>NZ_CP011125.1|WP_157069948.1|8921547_8922441_+|alpha/beta-fold-hydrolase
MGLLSLVEGLSHVALRARGLRGRMIDTAVGRVHAYVGRGHGALPPVVMVHGIGSAAAPFAPVIARVQEHVRAVIAPELPGHGWSAPPRGRLAPDTLFEVMGAVIDRLIDEPAVVVGNSLGGAVALDYARTRPEKVRALVLLSPAGARMSEDELEAVRRVFHLRSTADAIAFVERVYHRAPPGASWVAGDVRRQMGRAVVRELLANVRSDHGFDPDALRGLTMPVTLMWGRSERVLPASGLAYFRAHLPAHARVEEPEGVGHCPHLDRPGLVARRIVEAAISGSALEGARAHAGDPRA
>NZ_CP011125.1|WP_157069951.1|8922385_8923231_-|hypothetical-protein
MTRQPTIPSSSSSDVLVLVLLLASCAPTPPPHEPDVLATTGEELAAIPDTDVPDAIEPPPPTPCDAHPPSPTTLEPLGQRGILVLDASFPRELGTCLSPALVLREGAIECEPGSTRCRVGDRAILLAREHDDRCEPYALIRYPDTTPTTEPDDVLAALAHRDEACALHDRIALQDPSLYDATLRARRIQAGPRTALVAECLRDADAQTFAADARARFARVPLRCAGLRCESAAAADDAAAPAHSLVFANRLSGPLRFDAVAWVLTPEDHPRALELLRERCR
>NZ_CP011125.1|WP_053239090.1|8923227_8923695_-|NUDIX-domain-containing-protein
MVLLRRGARGIEMLVVHPGGPFFAKKHEGAWSIPKGMIEEGEDPLAAAQREVVEELGVTPPAPPYVALGDVRLKSGKRVHAWAARADFDPSRIVSNEFELEWPPRSGRLQRFPEVDRASWVDLETAKRLTSPALAPLFERAVSKETLDIVFGDPP
>NZ_CP011125.1|WP_053237468.1|8924145_8924487_-|nuclear-transport-factor-2-family-protein
MSTESEQLARRWLDAFNARDVDAMVALYADDATHTSPKIAAARIVGREALRAWWRGALERTPSLRYELVGIAASEDRVALEYVRHVDGEPAMPVCNVFDVQGGRFVASRVYHG
>NZ_CP011125.1|WP_169791684.1|8924483_8925023_-|hypothetical-protein
MTVESAILLLPWIALVALDRRALAGDVELSTLIEPIAARPVPGEYRTSIAYYRAVLALRAKDARSARALLDAVPRPLPRKRHAEAFEYLGALLDVVEGATERTLASAAAHEHGPRRASWLAVRAHAQAASGDVESARATLRMLRALRDPQLDLASVARWELPASRLASELMRGEEHPFR

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Crispr_ID: NZ_CP011125_35

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_35

8939172-8939283

Orphan

Consensus_repeat	Method
GACGGTAGGGCCCGGCGGGCGAGCCGATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_35

>merge|NZ_CP011125|35|8939172-8939283|CRISPRCasFinder
GACGGTAGGGCCCGGCGGGCGAGCCGATTCTTTCCCGGAGTGCTCGTCCCGCAGGCCCCGGACGGGAGCGCGCGAAGCGCGCAGACGGTAGGGCCCGGCGGGCGAGCCGATT

>NZ_CP011125|35|29|8939172-8939283|CRISPRCasFinder
GACGGTAGGGCCCGGCGGGCGAGCCGATT	CTTTCCCGGAGTGCTCGTCCCGCAGGCCCCGGACGGGAGCGCGCGAAGCGCGCA
GACGGTAGGGCCCGGCGGGCGAGCCGATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053237482.1\|8938380_8939115_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237487.1\|8942763_8943768_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069958.1\|8936620_8937277_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|275102
NZ_CP011125.1\|WP_053237479.1\|8935928_8936585_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NZ_CP011125.1\|WP_053237489.1\|8944651_8946268_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NZ_CP011125.1\|WP_053237481.1\|8937276_8938287_-\|aminopeptidase	unknown	unknown	gnl\|CDD\|225191
NZ_CP011125.1\|WP_053237478.1\|8935158_8935929_-\|3',5'-cyclic-nucleotide-phosphodiesterase	unknown	unknown	gnl\|CDD\|293821
NZ_CP011125.1\|WP_053237484.1\|8940154_8941138_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214748
NZ_CP011125.1\|WP_169791685.1\|8930403_8931564_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273654
NZ_CP011125.1\|WP_053237483.1\|8939353_8940073_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372974
NZ_CP011125.1\|WP_053239092.1\|8934444_8934885_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239315
NZ_CP011125.1\|WP_053237477.1\|8933916_8934234_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_083458271.1\|8931829_8932939_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340894
NZ_CP011125.1\|WP_053237476.1\|8933157_8933895_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157069961.1\|8943903_8944302_+\|four-helix-bundle-copper-binding-protein	unknown	unknown	gnl\|CDD\|153434
NZ_CP011125.1\|WP_053237491.1\|8948561_8949740_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237490.1\|8946269_8948423_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP011125.1\|WP_053237485.1\|8941180_8941651_+\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|225498
NZ_CP011125.1\|WP_053237486.1\|8941944_8942634_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237488.1\|8944406_8944655_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_157069958.1\|8936620_8937277_-\|glycosyltransferase	gnl\|CDD\|275102	TIGR04282, hypothetical_protein, transferase 1, rSAM/selenodomain-associated. Members of this protein family show strongly correlated phylogenetic distribution, and in most cases co-clustering, with an unusual radical SAM enzyme (TIGR04167) whose C-terminal pfam12345 domain often contains a selenocysteine residue. Other members of the conserved gene neighborhood include another putative glycosyltransferase, an alkylhydroperoxidase family protein (TIGR04169), and a phosphoesterase family protein (TIGR04168). The cassette is likely to be biosynthetic but its exact function is unknown. [Unknown function, Enzymes of unknown specificity].	2.36429e-47
NZ_CP011125.1\|WP_053237479.1\|8935928_8936585_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.61367e-34
NZ_CP011125.1\|WP_053237489.1\|8944651_8946268_+\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	1.28234e-37
NZ_CP011125.1\|WP_053237481.1\|8937276_8938287_-\|aminopeptidase	gnl\|CDD\|225191	COG2309, AmpS, Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism].	1.07547e-14
NZ_CP011125.1\|WP_053237478.1\|8935158_8935929_-\|3',5'-cyclic-nucleotide-phosphodiesterase	gnl\|CDD\|293821	cd07735, class_II_PDE_MBL-fold, class II cyclic nucleotide phosphodiesterases Saccharomyces cerevisiae PDE1, Dictyostelium discoideum PDE1 and PDE7, and related proteins; MBL-fold metallo-hydrolase domain. Cyclic nucleotide phosphodiesterases (PDEs) decompose the second messengers cyclic adenosine and guanosine 3',5'-monophosphate (cAMP and cGMP, respectively). Saccharomyces cerevisiae PDE1 and Dictyostelium discoideum PDE1 and PDE7, have dual cAMP/cGMP specificity. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	3.9876e-71
NZ_CP011125.1\|WP_053237484.1\|8940154_8941138_+\|hypothetical-protein	gnl\|CDD\|214748	smart00631, Zn_pept, Zn_pept domain.	1.00284e-39
NZ_CP011125.1\|WP_169791685.1\|8930403_8931564_-\|hypothetical-protein	gnl\|CDD\|273654	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490. This hypothetical equivalog is a member of the IB subfamily (TIGR01488) of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The sequences modelled here are all bacterial. The IB subfamily includes the enzyme phosphoserine phosphatase (TIGR00338). Due to this relationship, several of these sequences have been annotated as "phosphoserine phosphatase related proteins," or "Phosphoserine phosphatase-family enzymes." There is presently no evidence that any of the enzymes in this model possess PSPase activity. OMNI\|NTL01ML1250 is annotated as a "possible transferase," however this is due to the C-terminal domain found on this sequence which is homologous to a group of glycerol-phosphate acyltransferases (between trusted and noise to TIGR00530). A subset of these sequences including OMNI\|CC1962, the Caulobacter crescentus CicA protein cluster together and may represent a separate equivalog. [Unknown function, Enzymes of unknown specificity].	7.44972e-11
NZ_CP011125.1\|WP_053237483.1\|8939353_8940073_-\|hypothetical-protein	gnl\|CDD\|372974	pfam14234, DUF4336, Domain of unknown function (DUF4336).	0.00279768
NZ_CP011125.1\|WP_053239092.1\|8934444_8934885_-\|peroxiredoxin	gnl\|CDD\|239315	cd03017, PRX_BCP, Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing and detoxifying hydroperoxides. The protein was named BCP based on its electrophoretic mobility before its function was known. BCP shows substrate selectivity toward fatty acid hydroperoxides rather than hydrogen peroxide or alkyl hydroperoxides. BCP contains the peroxidatic cysteine but appears not to possess a resolving cysteine (some sequences, not all, contain a second cysteine but its role is still unknown). Unlike other PRXs, BCP exists as a monomer. The plant homolog of BCP is PRX Q, which is expressed only in leaves and is cellularly localized in the chloroplasts and the guard cells of stomata. Also included in this subfamily is the fungal nuclear protein, Dot5p (for disrupter of telomere silencing protein 5), which functions as an alkyl-hydroperoxide reductase during post-diauxic growth.	2.07241e-69
NZ_CP011125.1\|WP_083458271.1\|8931829_8932939_+\|hypothetical-protein	gnl\|CDD\|340894	cd17336, MFS_SLCO_OATP, Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters. Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	9.03085e-06
NZ_CP011125.1\|WP_157069961.1\|8943903_8944302_+\|four-helix-bundle-copper-binding-protein	gnl\|CDD\|153434	cd08026, DUF326, Cysteine-rich 4 helical bundle widely conserved in bacteria. This functionally uncharacterized protein forms a 4-helical bundle with a bromodomain-like topology. It is present in major bacterial lineages and contains highly conserved cysteines in a repeated pattern, whose sidechains appear buried. Some family members have been (mis)annotated as putative ferredoxins.	6.34611e-22
NZ_CP011125.1\|WP_053237490.1\|8946269_8948423_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	5.56644e-39
NZ_CP011125.1\|WP_053237485.1\|8941180_8941651_+\|EVE-domain-containing-protein	gnl\|CDD\|225498	COG2947, COG2947, Uncharacterized conserved protein [Function unknown].	3.90704e-69

>NZ_CP011125.1|WP_053237482.1|8938380_8939115_+|hypothetical-protein
MRFHLAALVLALGIASSARAQSAEDGWAPPTEEVRPTSGEASFLSGRTLGVGQVLMAAALGWPGLWAHVELAPDSTFNVGARVAVVYGSPVMGLVTGAGGELIVPMRVHLFGEGDVDLALRIAPQVALGEGRLFGEAEGVRANDLGVSSRLEVGPRLGWRVAERVTVLAGVDAGAGVSWTNGEDVRAIGTFSATLGIEALMTLQTMLFAEVSGGAGVADGSGRAVPLYPQQEIFRLSLGLAYVL
>NZ_CP011125.1|WP_053237481.1|8937276_8938287_-|aminopeptidase
MSATALSRVTVSQLDLAAREVVGSALAVREREVVAIFADATSVRMGDALARAVEARGAEPRMIWLDDLGPRPLLELPVGIDVVLEGMTASAFVASAPAPEITMRRALLAKLTGQRVRHAHMPGVSHLAFVRGLRVDYDAVAGHGMRLLARLTSSTRITVSSASGTRLRIATSPATRWMPQLGQLEPGRWGNLPAGALYAVPDSIDGVYVANAAVGPHATSSTPVTLYIADGRVVRLAAEDDPVLEQMLRARIESAPNRDRVGLVAIGCNYGIVESTGEAIVDQNMPGLHLALGDAASDVTGVAWSAAGSLPCCAAGTSVVVDGEAIVRSGVLVDPS
>NZ_CP011125.1|WP_157069958.1|8936620_8937277_-|glycosyltransferase
MRVAIFARPPIPGRCKTRLARAIGDVRAAELHAAFVIDTLEHVRAREGLRPELHVTELHPFFAQLRARFELPPPIVQVEGDLGARMRHALDREPGPACVIGTDAPTLPHALIGRASIALGDDDFVCTPTSDGGYALIGSAGRAPSTFLEDPRIRWSSRHALADTMRAAPSRIALTAPWYDVDEPADLALLGTHLTLDPRAAPATAALLLGQRRRTSTF
>NZ_CP011125.1|WP_053237479.1|8935928_8936585_-|Crp/Fnr-family-transcriptional-regulator
MGEGDALFARFGRTFEPGEVLFREDEPGNTMFVIQQGQVRITKATRDGTKTLAILGPGEFFGEMAILNSKPRNATAEALSPLRCLVIDARTFGQMVVSNAEIAVRMITKLARRLDSANALIEVLMHRDPKARVILGLSRQAEMIGEERDDGSVWVPITRTDLAAEIGLSEEETEDVLVRLRRLRIVEGGDDGFVVGDVQRLQEFLEFLEMRERFGDGN
>NZ_CP011125.1|WP_053237478.1|8935158_8935929_-|3',5'-cyclic-nucleotide-phosphodiesterase
MELRVLGCHGGETPKHKTSSFLLDGKVAIDAGAVTSMLTLEEQHAIETVLVSHAHLDHVRDLATLADNRCQQGGPPLVIAGIPETLEVLKKHFFNDLLWPDFSKIPAGSSGMTIELRPLVPEETTELSGMRITPVLVHHTIDASGFVVETPSGALGYSGDTGPTTRFWEKLNATRDLRALLMEISFPDEHHKLAKVSGHHTPETLEAELQKLHDHRELPVLLYHIKPVFEQRVEKELSRIRDRNLDICRLGDQFVL
>NZ_CP011125.1|WP_053239092.1|8934444_8934885_-|peroxiredoxin
MPVGEAAPAFMLQDQTGRVRQLSEYRGHPVVLYFYPRDATPGCTAEACAFRDAWDRLQGTGAVVLGVSTDDVESHRRFHDEHQLPFELLADLDGRVAQQYGVPMQMGMTARMTFLIDDEGVVRHVWEDVDPGVHVDEVIAEIDELP
>NZ_CP011125.1|WP_053237477.1|8933916_8934234_-|hypothetical-protein
MTVLSTEPADVLKRRAQRFASKGEYRKAALALRERAAIVGDAASWVMAGAMLRRARRDDEAIEALRQGLWLHERAGAAGRAQAVANVLRELAPDDRLLRRYAKAS
>NZ_CP011125.1|WP_053237476.1|8933157_8933895_+|hypothetical-protein
MQSPRDPRSIRPGLVVVSTLVLALLALGVGGVVTQHARTTDDDEEEDRGGRTFVLEPATDDDADRDDDGWARAVDDPGAEGSAREAWAQAFTDRDEPLPPLVEAVVDPQMSRYRAVYTEAPPPFTPIGRRGRVLASSGLDIDSAQPCEVRVLPAADSGFNCLVRVMCGETVVYPNRAQTAGYVACDLGEGGPSAAADSNPSVTDGDPAIAFDLARGTVTVRDADREGRSLFEVTLQLDPTALRVM
>NZ_CP011125.1|WP_083458271.1|8931829_8932939_+|hypothetical-protein
MHDRSILPLRAARALRPAFALLLGIPLLLAPRGCEEPGDPDTCFCADIYAPVCGADGRTYGNACEAECVGAMIAHEGECDAGCVCPAVYAPVCGDDGKTYGNTCEAACAGVMVVRDGECETSCACPDVYAPVCGQDGRTYGNACEANCAGVMVDHEGRCECPAIPPIYCEWGYVVDQNGCPTPECLPPPTCEPVMCEIACEFGHVIDERGCAICACNPPPMCEPVLCDVYCEHGHARDERGCETCACDPPPVCEPVLCDVYCEHGHARDERGCETCACNPPPADLCLSDDECGAGAYCDHTVCRSPCEGLPDDRACPAVCYGECRPTPPPSCSADADCAAGEVCVVPVCIWDDPSAPCPDEGTCVPVER
>NZ_CP011125.1|WP_169791685.1|8930403_8931564_-|hypothetical-protein
MRTNVVAWGLCWWVVLAACGATRAREERRVPVTLREEGWLPENRARIERVIGELGARDGRRVAVFDWDNTMMRGDIGDLVLAHLIERGAIAEGVIPQGDAMLSAAAHEALARASDATERGRVVAHLAWRGTTPEGEPAFTVSVGPFYRATYGVIAQVLAAGRTDDALRAIAREAFTAASVAPIGAREVIGGVEVERFARLHAPMIELARALEAIGVEVWIVSASPEPIVEAIAEIAGLDPARVVGVRMEHDDAGRGTSRFEACGEGPLATPVMTWLEGKRCWINREIFGVPSARQRMRQDDPALRPVLVAGDSDGDLAMLQDATALAIVLDRQNVRVMCNALASGWVVQPLFVDPPAPRTTPYPCSTHEDTLGRVVDVEGRAIADR
>NZ_CP011125.1|WP_053237483.1|8939353_8940073_-|hypothetical-protein
MPKAFEEWKVLSHGPIEVLASNLWRVWGSLPGMSLKRTMTIVRLADGRLVVHSGIALGAREMERIEAWGAPAFLVVPNAGHRLDAKAYAARYPHARVVAPRGAKKGVEEVVHVDATYADVDVGDASVRFETLAGVDEGEGAMIVRSDDGVTVVLNDCVMNMDRKRDPLGFFFTTLLGSAPGPRVSRLVRRVFVKDRSALRRDLERLAALPDLTRLVVSHEKVAHGAEARRALERAATYL
>NZ_CP011125.1|WP_053237484.1|8940154_8941138_+|hypothetical-protein
MSADDLAALADAIAPFLDDPPLRDDVDLTRIGRYRGFGEVVGAIAALRDRGARVTVAGRSHEGAPVLRVDIGDVRASSGSLMIAGTHAMEWIGVEVALAILDAIADEPGDRRIVAFPVLNPDGYRRAERDLRSGRKMRYSRANARGVDLNRNWPTHWAPTGLIPRVLPLLGSAGSHPASEPEIRAVLDTILEVKEAGHTRLERALSLHSFGAVLLLPYGGRWALPPEHPRLHAMAREVRRALRKRYGIRSVARWVPGFFAHGMEVDHLLHEGMSPLLVECSRGGLSFFDPSSWVVPFRWYNPPRPVRHVTELQHALLPFLGFGHASE
>NZ_CP011125.1|WP_053237485.1|8941180_8941651_+|EVE-domain-containing-protein
MKLWLMKSEPDVFSIQDLARDRTTTWEGVRNYQARNFMRDDMKVGDLVLYYHSNADPSGVAGVARVAKLAYPDPTQFDPKSEYYDEGSPKDDPRWLMVDVEFVEAFDEVVSLDRLKSDKALDGMLVIKKGQRLSVQPVEKKHFARVLKLAGAKTKL
>NZ_CP011125.1|WP_053237486.1|8941944_8942634_-|hypothetical-protein
MGDTVELPSGRLEVETRPGYLFIVEHGTLRNVDEVDQYAAALELLVGRTGVRRALIDSRAADAIELPPDVRDALWRWLLTARVFEQIAFVLGSEMAVVRVNMVARSHRAGICAFGAVHEAHRWLSGRQRTLSQTFSAPLGAMSQTPVPPPRAEREPRSSVPPPPPPRTKSDVYPARDASGAPMPQRASSASTGRFTALPPARAPSQPGLEQVRPTRELEPARRKKVEET
>NZ_CP011125.1|WP_053237487.1|8942763_8943768_-|hypothetical-protein
MTREISSEKRIAIGRNRDGRLEVFFVGKDGVLRHNWQSRPNGLWEGESSLKQNAIEVGCGVNADGRLEVFWVAPDGTLMHDWQLTPGGKWAGAEDLKAKAKALAVASNADGRLEVFYVGADGALHHDWQLAPNGDWNGPEKLAKVASAVAVGRNQDGRLEVFYVGENGAVMHDWQKEPNGDWFGAEALQGKAREIVVGSNADGRLEVFWRDDLDIVWHDWQLEPNGDWHGQESLGVKAKRIDVAENRDGRLEVFYVDGDKKIRNLWQVHANGDWGTDQEVLGDEATDLAIGQNQDGRLELFYFGRGSEIWHNWQPRPNAGPWNPIVRYDEPTVG
>NZ_CP011125.1|WP_157069961.1|8943903_8944302_+|four-helix-bundle-copper-binding-protein
MEMTARMLEMTPGIRMRSDRALLACIDACFECAQVCTLCANACLQERMVAMLRQCIRLNLDCADVCDATGRVLSRVGPHGTRMARTMVEACAIACEECARECEQHADVHEHCRLCAEACRRCERACRALLAS
>NZ_CP011125.1|WP_053237488.1|8944406_8944655_+|hypothetical-protein
MLAIAIRLVASLAVAVCVAAGMTRWVPPGGGVDHVVVPVVVFPVIWATAFLVLQVRRGRSGTSVAALVAVSAASLLPFVMAR
>NZ_CP011125.1|WP_053237489.1|8944651_8946268_+|PepSY-domain-containing-protein
MSEPSASGPSTRRRLFEVHTWSGLLVGLLGFVVIGSGAIVVFADDIDVWAHRDRPHPELHDVDALGLERAIARVATTVPPEHLEDIGLWTAHGSVVAWMHHHTTDASGAPIERGTVVHLDPASWGERARRSGTVDEVFAPSPREALSRFFVDLHIRLFLPDTTGLWATGLVGFGLLLLVVTGLFVHRPFFRHATRVRGTAAPRKLLHDLHTVVAVWTLPFTAVLSLTGAFLSFGGALVFPLLTEAAFGGDEAALDRAFSGAPEPAAEIAIAPATTALGAALTDARSRSEHDARRVEWIEVAHWSRSDAHMTLYTSPVFGPQYDVSHRYDGDGTWRSVRACFGNGQSFGGALYQWMSALHYGNFGGGLVRALWMLLGVLAASLALTGLGIWSVRRTGGAEARAGRVAGVLTIGAGLGLPLGAAVAVHAWALANASGASPYAAMAVSLVLGPAIVVWHAARRSFRSVLRLGLVALGVACVLAPLTALVAVGDAFGAAWWIDVTFAVTGIAAIAAGARIGRAVAPDVVRRVAVSGPSAREA
>NZ_CP011125.1|WP_053237490.1|8946269_8948423_+|TonB-dependent-receptor
MSARVAVLIALALATCASRALAQDPDAPDPASDELDDDDLLTEDVVVSTTSEADAIAESADSVLVLETDVVRIQAADAGEVLARQEGISVRRGGGLGSSARICIHGICDAGIRYFLDGVPLELAGFGHGISNVPLSMVERVEIYRGAVPIRLGTDALGGVIDLVREQAYFVPHASASLLAGSWGTYRAYVDGGYRHDASGFYAGASAFVDHADNDYPIDVLVTDAAGRLSPARVRRFHDAYDAYGVAAEVGLVGVPFADRLLLRGFVNEYDRELQHNVVMTVPYGEVTYGEVSAGGLLRYSHTIDTQWSIDAFAGYTRREITFRDASTWVYDWHGRRVRERRVAGEIDPRARDQVVWEDAAPARLTLSFQLTPEHLFVANVTPEFTSRSGDERVQVDPMARDPLSAQRDLFTMVSGIEHRMSVFDDALETSLFIKDYVYASASEEVLRDSIVARHDRSTHDVGAGAAARYRIADGILARATYEYATRLPEPYEVFGDGVLVVENLDLLPERSHNATLEGSLDVRADPGRFEASIAGFVRARENMIVLLGTQRSFSYQNVYSALVVGGEASVRWTSPGDWVVLAANATYQEDRNTSAEGTFARVRGDRIPNRPFLFANFSAELHASGVLGHRDELTLGWRGRYVHEFFRGWESQGSVEHKQTVSSQLAQDVWLTYVVDGEPRISTSLEVQNLADAALFDFFGAQRPGRSFFVRVTAEL
>NZ_CP011125.1|WP_053237491.1|8948561_8949740_+|hypothetical-protein
MLAGAVGCGGDDDTGGGPGPEGPLYAVMYEVYDDVGSTSYLSLLDSLDIEEIDTTRTREYGGGRAFIQAYNGWLFVGEAQSPTVIRYSVDDDGELVEEGRVSFSNYGLESAVLDDWAITWLSPTKAYLVNFADGRTIIWNPTTMEITGEIEPAEEFLREGLSLEGAPAAVRGNLLFRTFNWVNYDTAEYSTDFLLAIYDTDSDELIELVTETRCPVPGNLVHQDEAGNIYFSNWLWPLAGTIMRDAPESCVLRIAPGETRFDPEWTLDYADVTDGHHGAMFTYVGDGEALASAFYDERTSFDETTNPWSYLSTLNWRIWRFDIDDPSTAAPLEGLDFNGGAFTPVQFDDRLLLMVPGGEAEGYATQIYEVEGNQATPRVRLPGWSYQFVKLR

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Crispr_ID: NZ_CP011125_36

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_36

9142981-9143063

Orphan

Consensus_repeat	Method
GGGCACGTCACGCCGCCGCACGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_36

>merge|NZ_CP011125|36|9142981-9143063|CRISPRCasFinder
GGGCACGTCACGCCGCCGCACGCATCGACGCAGGCGCCGCCGCGGCAGCGCTCGCCGGGCGGGCACGTCACGCCGACGCACGC

>NZ_CP011125|36|30|9142981-9143063|CRISPRCasFinder
GGGCACGTCACGCCGCCGCACGC	ATCGACGCAGGCGCCGCCGCGGCAGCGCTCGCCGGGC
GGGCACGTCACGCCGACGCACGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053237661.1\|9145460_9148214_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223700
NZ_CP011125.1\|WP_053237663.1\|9149010_9149847_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235545
NZ_CP011125.1\|WP_075097729.1\|9136846_9137908_+\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|215219
NZ_CP011125.1\|WP_157070025.1\|9144377_9144863_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237654.1\|9140153_9140471_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237660.1\|9145024_9145435_+\|VanZ-family-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_075097728.1\|9135658_9136786_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226019
NZ_CP011125.1\|WP_053237655.1\|9140491_9141067_-\|YdeI/OmpD-associated-family-protein	unknown	unknown	gnl\|CDD\|226851
NZ_CP011125.1\|WP_053237662.1\|9148336_9148927_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|379122
NZ_CP011125.1\|WP_053237652.1\|9137955_9138612_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237664.1\|9149847_9150036_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237667.1\|9152089_9152596_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237648.1\|9133372_9133978_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237656.1\|9141063_9142425_-\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NZ_CP011125.1\|WP_053237666.1\|9150337_9152089_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|226179
NZ_CP011125.1\|WP_053237665.1\|9150048_9150270_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237650.1\|9134988_9135636_-\|outer-membrane-lipoprotein-carrier-protein-LolA	unknown	unknown	gnl\|CDD\|319983
NZ_CP011125.1\|WP_169791271.1\|9152592_9153168_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237653.1\|9139125_9140124_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369445
NZ_CP011125.1\|WP_075098126.1\|9133984_9134989_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271139

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053237663.1\|9149010_9149847_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235545	PRK05650, PRK05650, SDR family oxidoreductase.	3.71243e-86
NZ_CP011125.1\|WP_075097729.1\|9136846_9137908_+\|biotin-synthase-BioB	gnl\|CDD\|215219	PLN02389, PLN02389, biotin synthase.	9.93695e-169
NZ_CP011125.1\|WP_053237650.1\|9134988_9135636_-\|outer-membrane-lipoprotein-carrier-protein-LolA	gnl\|CDD\|319983	cd16325, LolA, LolA, a periplasmic chaperone. This family contains periplasmic molecular chaperone LolA which binds to outer-membrane specific lipoproteins and transports them from inner membrane to outer membrane (OM) through LolB, a lipoprotein anchored to outer membranes. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts OM-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. Studies have shown that hydrophobic surface patches large enough to accommodate acyl chains of the OM lipoproteins and the structural flexibility of LolA are important factors for its role as a periplasmic chaperone.	1.6663e-26
NZ_CP011125.1\|WP_053237656.1\|9141063_9142425_-\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	4.61927e-105
NZ_CP011125.1\|WP_053237666.1\|9150337_9152089_+\|amidohydrolase-family-protein	gnl\|CDD\|226179	COG3653, COG3653, N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism].	8.36271e-119
NZ_CP011125.1\|WP_053237662.1\|9148336_9148927_-\|HD-domain-containing-protein	gnl\|CDD\|379122	pfam13328, HD_4, HD domain. HD domains are metal dependent phosphohydrolases.	3.94875e-24
NZ_CP011125.1\|WP_053237653.1\|9139125_9140124_+\|hypothetical-protein	gnl\|CDD\|369445	pfam07635, PSCyt1, Planctomycete cytochrome C. These proteins share a region of homology at their N-terminus that contains the C-{CPWHF}-{CPWR}-C-H-{CFYW} motif typical of cytochromes C, or CxxCH.	3.1084e-07
NZ_CP011125.1\|WP_053237661.1\|9145460_9148214_-\|hypothetical-protein	gnl\|CDD\|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	0.00288927
NZ_CP011125.1\|WP_053237655.1\|9140491_9141067_-\|YdeI/OmpD-associated-family-protein	gnl\|CDD\|226851	COG4430, COG4430, Uncharacterized protein conserved in bacteria [Function unknown].	6.21821e-48
NZ_CP011125.1\|WP_075097728.1\|9135658_9136786_-\|hypothetical-protein	gnl\|CDD\|226019	COG3488, COG3488, Predicted thiol oxidoreductase [Energy production and conversion].	4.60377e-53
NZ_CP011125.1\|WP_075098126.1\|9133984_9134989_-\|hypothetical-protein	gnl\|CDD\|271139	cd14656, Imelysin-like_EfeO, EfeO is a component of the EfeUOB operon. This family includes the EfeO domain, an essential component of the EfeUOB operon which is highly conserved in bacteria. However, its biochemical function is unknown. EfeO contains an N-terminal cupredoxin (CUP)-like domain and C-terminal imelysin-like domain that may bind iron. Algp7, a member of EfeO family protein from Sphingomonas sp. A1, is found to bind alginate at neutral pH, but does not contain the CUP domain, thus having a role that does not seem to be related to iron uptake. Some members of this family are fused to an N-terminal putative EfeU ion permease domain. The imelysin-like domain of this family also contains the GxHxxE sequence motif and a highly conserved functional site, suggesting a similar role to other imelysin family proteins containing the same motif.	5.80177e-20

>NZ_CP011125.1|WP_053237656.1|9141063_9142425_-|glycoside-hydrolase-family-1-protein
MSRPTIEREDASRAQRGASAITFPPRFLWGTATSSHQVEGAQTQSDWAAWEARTGRIHGGDRAGRACEWWAGRAEEDFARARTMGHSAIRLSLEWSRLEPRPGVFDEGAFDRYARLLEKARELGLTTMVGLNHFTLPYWLAVRGSWLAEDAPDRFARYADRCARRLGDLVPLWTTLNEPSVLALMGYVGTAWPPGRGNPALGMKALRAQLVAHGAAFHAVHDARPDAQVGLVINMPALDPFDPSSVRDRAVAAAQDWAFNGVVLDALAHARFRFPLALREERAPILRVSGGPALDFVGLNYYGRYRVRFDARHPGELFGRRDARDTVHTDSNDWGEIHPEGLTRQLLRLSRTFPRLPLYVTENGMFDPTDTRRPSYLVSHVRAVHDAIAQGADVRGYFVWSLLDNFEWAEGWSTPFGLLALDRATQARTARRSADVYSAICRANGVSDAMEVR
>NZ_CP011125.1|WP_053237655.1|9140491_9141067_-|YdeI/OmpD-associated-family-protein
MTTDETRTFASPDAWREWLEANHTSSRGLWLRLAKKGTGTPSVTYPEALDVALCFGWIDGQKKGDGAEWWLQRFTPRGARSIWSKINRAKAEALIASGAMREAGLREVERAKADGRWDAAYDSPSNAKVPEDLEAALAKSAEARASFATLDATNRYAILHRLQTAKKPETRARRIEQFVAMLERGEKIHER
>NZ_CP011125.1|WP_053237654.1|9140153_9140471_-|hypothetical-protein
MRLNVSFPPPGFFLNDPRLVVTLGDRMLYDGSFRDGFSVSVEIEPGEHVLETAIHLAGTIARKQRFELKLDPASGFRQVAIVDAKLTYSRLSGNFDKRVSLSTRG
>NZ_CP011125.1|WP_053237653.1|9139125_9140124_+|hypothetical-protein
MHHRICVLLVSLGATSSLACSLERVGFEPPPRDCPGQDCPAPAGDGGTPRPGACGDAVCAAGEDCASCPADCGACTDACESGLAPNVDYGEDVQPIFDARCVGCHGGTDPAAGLRLDTLLGLLAGSASGPVITPCSCRDSLLWKKLGPDPFTGDRMPLGGAPLSDAEIARICQWLDEGAESRFDPTTCGAPVGPPRGACDECGDGVCGVTESCGSCVIDCGCEPPPPERDVTAPAFEGARDAESPSPAQCVVSWRPAVDDVTPSEAIVYEVFAGPRDTVPDLSRPVAVTAPGATSHVLAIGPGERVDVVVRAVDAAGNRDTNLRARECDGRD
>NZ_CP011125.1|WP_053237652.1|9137955_9138612_-|hypothetical-protein
MSLPTDDRASTIILRDARYHRASIKADPTTAHLAERVETGERVLRDAAQATEAAEDARVEAYARLVRADYALDARTRRVELEVLTAVLRDRSTPGYRACFPQGLTALIALRGEEQERATRSLVAALGVHFPDVAAAHGAALTELAAAAVTAERAWLETERLLSAAMGDERLARVELIRALQRNEGALIELFPGDKRQAKSYFRKSARRGRKGDPSGEE
>NZ_CP011125.1|WP_075097729.1|9136846_9137908_+|biotin-synthase-BioB
MQSPEIRHDWTLDEVLAIHELPLTDLLLRAQMVHRRFHPPDSVQLCTLLSVKTGGCPEDCGYCPQSSKHDTSVEPERLLSVDEVLSSARRARESGSTRFCMGAAWREVKDGPAFDRVVDMVKGVRELGLEACATLGMLTEDQAKKLAAAGLTAYNHNLDTSREHYGEIISTRTYDDRLKTISNVAKAGISLCCGGILGMGESTRDRCEMLRTLAALDPQPGSVPINALVAVEGTPLEDQPKVDPIDMVRAIATARIVMPRAMVRLSAGRADLSREAQILCFMAGANSIFYGDKLLTTGNPDVAADRALLHDAGMKPMLPYASPDPTVQSTRERGPQPKPGTIALSARIPADAE
>NZ_CP011125.1|WP_075097728.1|9135658_9136786_-|hypothetical-protein
MRAWAAVGIALAAACGDEPPALPEIAAAPIERVVEDPSDAPLAGLSEEELVRFEDGDARFELPFREAQGLGPLYIHRACTSCHEDDARGPGAVRRIVRRGADAPALPWGDVVRPRMTAGASVPVMAPAHPAIGEAVRLAPAVFARGLIEAIPDAAIEANARRGTGGRVARLRDGRIGRFGHKARTATLDEFVADALLGDMGLTSPVRPEELPGPEGIRDDAKPGVDVSDEEIALLADYVRLLAMPRREARDGTVFEEIGCATCHLPSMRTRDDHPVRALRDVDAAIYSDLLLHDMGDGLADGIEEGAASGREWRTAPLVGVRHLRGLMHDGRARTVREAIDAHASEGSEANEVVARWRALGEDEQRALITFVEAL
>NZ_CP011125.1|WP_053237650.1|9134988_9135636_-|outer-membrane-lipoprotein-carrier-protein-LolA
MKRRELVGALLLLGAPGIALAQARPTAAELVARVDAFHGRTRTIRARFSQFFWSRAYGRTSTSRGRIAIERPGRVRFDYDPPNGKIFVAEGARWLMYEPFDGGPGQFSRGTSSALIAALGILSGAISLDAYRASVADRSAGAPADTDALELVPVQRDPHHRCVRLHVDARGAVRRVGLLDHEGNWNTFALDELAFDAPIDPSTFSFTPPAGAREL
>NZ_CP011125.1|WP_075098126.1|9133984_9134989_-|hypothetical-protein
MRGAWLGLVLVACGARDEAPIVAPDEQATRAVKSYVDAEVAELARACDALCAAAPAPDADGWSIASDREAVERMRAEWRRARRAYEHVEGAIAILFPDTDAAVDGRYEHEVELRRDDTPFDANGFVGMHAIERILWSDAIPAPTERFERALASYTPPRTPASEAEARAFQGALCARLSRDVRAMERALGPLALDPATAWRGIVGSIEEQAEKVRLGTTGEDESRYAQHTLADMRANLEGGRAVLDAFAAMPIAADERAAIDRELRALERVYAESGEDALPPVPDGFDPDAPRDDTPYGRLFVMLSRASDPRAEGSLAARLRRAGEAMGIAPIAR
>NZ_CP011125.1|WP_053237648.1|9133372_9133978_-|hypothetical-protein
MRSAFASLVVVLVAAALTGALVSVASTVEMPAVASAPSDAGVDAGSGPFVAFARDFAGFRRWERIAVEGAMVPIGAPEGPTYVYASGRAPEGASRWPVGTILVKSIEVGPPSAWTIHAMVKRGVPYNRAGTIGWEFFELRFPEGEEDAPVIVWRGPGPPSGHGYAAMHRDAGTEPVALVCNDCHAAAWQSDGAITPALSLR
>NZ_CP011125.1|WP_157070025.1|9144377_9144863_-|hypothetical-protein
MSALLAFDATLQRALLDLVVATLWADGDVADREIAAARGAQIALGLVHPSDDAASAIGHGPSDAWRTLAGASDRERLLAYAAAVWTALADRVIDPGEARFLREVRHALALDDGAVRFADTLARWIDADARDASLPAHRSFAQLLVQGARRVAQVEARRAAA
>NZ_CP011125.1|WP_053237660.1|9145024_9145435_+|VanZ-family-protein
MGTERRGAVALATMVAVALATLVVLADTDRITPLLVFVHAVPLGDKLGHLVLIGLLALVVELATAGRVVSIARAPIRIGSAVVLALVVLEEISQRWVPARSFDYGDLAADVIGIAVLGTLGARLARQRARTTGAAT
>NZ_CP011125.1|WP_053237661.1|9145460_9148214_-|hypothetical-protein
MSCRIRALLFTSIVLSLTGCGDDDVAPPAPDGGTPCVLQPVAWSHASVGVTVGATRDVTIELTRPFSCNDVSLSFETSGAGSIEALPGDLVIEPLGTSRHALEITGVSEGVLTVTATATSEDGQRVEAELEVAITGTTVPQCEGEASGNVAPGGAIEATSGSLRGARIALAEGASREDEFQVDAFDAQIACASDAIVPEGYRALGPAVSLASSAGRTRFPRELDLAVPIRLALLPSHAHRGHVEVAYVGPGVTEPRIVPIADPVFEGSAGDGVFHFRAPRLGTYQVVTRDEGPQRRDRRFVYRGITGVSMGGSGSGRVGLGNPDRFDFVAPLGGPTDWQYMLEYIRRYHLGGFCTEEERQSGTVDCSAASQDRAPARGQFMEHVQHFENWWYEDAYDGQGGRFDRREYLEIFRDLSAMFGNANTDAGLDADDPNVAPPGTPDSERYRLPAERCALENVIRIAPEPEGGDELAATGWFDDEYNPEGRYPVISFCDGAEVPGDTGRWAPEGDNSAPAEVAYAVDVNGNGRRDPGEPVIRNGREPYRDVGSDGLPSEMEEGYDAITNPDPAGDDYDFQYNPLGTEGDWDRQDGEPFDDFGIDGVDGTAQLADGGYDSGEGDGVFTRTQGAQRMIDASPRGMLREMDDATARAQDVFADGGVRDLFNWVVMGHHSMGAFASRGIPVRFYNGHSALYLDGRDQDFVFSAVPWNEIGRHAMVRYGSIDATEQEKINGDGGHVGTVVQIQHRLFSSLAAMDRRWPGGDREVVRDSLCSEIGSGCDHVNSIELDFDAPTAQRSGPVTIILPPGYFHPQYAEYRYPVVYFLHGYGMEPSDLLATGLLLWNFMSDARLPQAQRFQKAIFVFPDGRCRGAECVNGTFYTDAPESTPNGPAMETFLLDVVDYVDATYRTRAPETIQVWE
>NZ_CP011125.1|WP_053237662.1|9148336_9148927_-|HD-domain-containing-protein
MAHAFYGPRVGEALQLAADAFAARARKGSGAPYLTHLLSVTTLVMEHGGDEDQICAAALHDYLEDIPGAQASELEARFGARVTRLVRALSDATDAQNKAPWKPRKLAYLAHLRDEPAEVKLISAADKLHNARSIVDDHQRMGDEVFTRFTASREETLWYYREVVRALAHDFDHPLVDRLRDAVRDIHRATGLDADV
>NZ_CP011125.1|WP_053237663.1|9149010_9149847_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTTSKIPSGARSVITGAGSGFGRAVSLALAERGARLLLSDVSKEGLAESVSMARGKGAQIESMIVDVRDAAQIEGMAKRAEEMWGGVDVLVNNAGVAVAGEVGSIPLDDWKWQVDINLWGVIYGCHYFVPKMKAHKSGWILNVASIAGVVSAPMMGPYNVTKAGVIALSETLATELATSGIKVTALCPSFFRTNIHKGSRATGMLTGRTEKLVTQSKWSAEEIAEHALRGLERGQLYVMPQSDAKAMWRLKRALGGGFFGAIGAAAKRGVLDRVMGRD
>NZ_CP011125.1|WP_053237664.1|9149847_9150036_-|hypothetical-protein
MAETFDRGREPFGSGLSPRALKGALLGALLLLIVPTLLVIAMIAWSHATTHVEHQPSVEPAR
>NZ_CP011125.1|WP_053237665.1|9150048_9150270_-|hypothetical-protein
MHAFAREDAKMAEVYSRHPLEPNTKSDARKLVAIVLFALLVPPLVATLILLIAEVGDRNRIVVPDDRAIESAK
>NZ_CP011125.1|WP_053237666.1|9150337_9152089_+|amidohydrolase-family-protein
MAYDLAIVNGMVVDGTGAPARRADVGVKDGRIVAIGALEERAARTIDAEGALVTPGFVDLHTHYDGQASWDASMLPSSAHGVTTAVMGNCGVGFAPVRPRDRERLIALMEGVEDIPGSALAEGIRWEWEQFGEYLDALDRRPRTIDVAAQVPHDALRVYVMGERAVAGGRATDDDVAGMRAMLRAALEQGALGFSTGRSDNHRAKDGSETPAADAEARELAGIARAFEGLGRGVLQAVSDFDMHVSPERFDPEFDVLEAMAEAAGRPLAISTLQRDSATDQWRKILARIERASARGVTMNALVAPRPIGVILGLDATFHPFIGFPSYKAIAHLPLAERVAILSRPDVKAKLLSERSEKVAGDGSPIPPLADQLLAAIDFVAMRLFRMGATPSYEPQRQDALFAEAMRRGVPALEVVYDALLEESGNALLYFPLYNYGGYSLDDVAEMLHHPRAMVSLGDGGAHVGTICDASMFTYFLVHWARDRERGRFSIEDAVRKLTSEPARWAGLVDRGEIAIGRRADLNVIELDRLALRAPRLVRDLPAGGKRFLQDAIGYRATIVRGEPIAIDGALTGATPGRIVRAS
>NZ_CP011125.1|WP_053237667.1|9152089_9152596_-|hypothetical-protein
MKRSTFAQRLAETIAWCAPRAGIGDPRRSLRDPQLQPQLLARDRAQTVAWLVSRRDRRVRGEPIPPSTRPASGRLLVYFPDANLSCGAAELETDGFFDADNVPPWDTWISVHDRAHGCPSYGSMLVCWVPPALVELVDRGIDVNPEQCIVWIDALELDLDALWRAEVD
>NZ_CP011125.1|WP_169791271.1|9152592_9153168_-|hypothetical-protein
MRTSGSSSRNSDRGAHGLRTPRIACDRTLAVRSIAGETVAIYYNLAAFVGARDEAEAFVAHFHGRTIPIEHGDLVLDITLRETPQGWLVGLWPVGMSYGTCDDARLVAPEAREAAARWFERELRGAPTFRAAAFGAEIYDTFLDTTLAELVDGGGMPGLVLDIRTHVSLRSPAGTKPFGPGRRWWPRTKTP

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Crispr_ID: NZ_CP011125_37

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_37

9236091-9236198

Orphan

Consensus_repeat	Method
GTCGCCGTCGGAGTCGAGATCGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_37

>merge|NZ_CP011125|37|9236091-9236198|CRISPRCasFinder
GTCGCCGTCGACGTCGGCGTCGCGGAAGTCGGGCAGGCCGTCCTCGTCGAGATCGGTCGTGCCCTGCGACGCGTCGGGCACGCCGTCGCCGTTCGACTCGAGGTCGAG

>NZ_CP011125|37|31|9236091-9236198|CRISPRCasFinder
GTCGCCGTCGACGTCGGCGTCGCG	GAAGTCGGGCAGGCCGTCCTCGTCGAGATCGGTCGTGCCCTGCGACGCGTCGGGCACGCC
GTCGCCGTTCGACTCGAGGTCGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053237748.1\|9236528_9237071_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380149
NZ_CP011125.1\|WP_053237751.1\|9240085_9240718_-\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|223698
NZ_CP011125.1\|WP_053237745.1\|9229198_9230884_+\|CHASE-domain-containing-protein	unknown	unknown	gnl\|CDD\|377162
NZ_CP011125.1\|WP_053237744.1\|9228142_9229099_-\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|223512
NZ_CP011125.1\|WP_053237749.1\|9237211_9239407_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237743.1\|9227366_9228173_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|367049
NZ_CP011125.1\|WP_053237742.1\|9226314_9227187_-\|acyl-CoA-thioesterase-II	unknown	unknown	gnl\|CDD\|224857
NZ_CP011125.1\|WP_157070080.1\|9243737_9244184_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379608
NZ_CP011125.1\|WP_053237754.1\|9242949_9243666_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157068918.1\|9232602_9233922_+\|transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP011125.1\|WP_053237741.1\|9225369_9226143_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP011125.1\|WP_053237753.1\|9242624_9242942_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053239103.1\|9240860_9242021_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341462
NZ_CP011125.1\|WP_053237740.1\|9222715_9225337_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|274362
NZ_CP011125.1\|WP_053237750.1\|9239504_9240080_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237752.1\|9242020_9242365_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NZ_CP011125.1\|WP_053237738.1\|9220050_9220380_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070073.1\|9220369_9222307_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238119
NZ_CP011125.1\|WP_157070078.1\|9242451_9242625_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791697.1\|9231053_9232079_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053237748.1\|9236528_9237071_-\|hypothetical-protein	gnl\|CDD\|380149	NF012181, MSCRAMM_SdrD, MSCRAMM family adhesin SdrD. Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.	2.9818e-05
NZ_CP011125.1\|WP_053237751.1\|9240085_9240718_-\|glutathione-S-transferase-family-protein	gnl\|CDD\|223698	COG0625, Gst, Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	1.01305e-06
NZ_CP011125.1\|WP_053237744.1\|9228142_9229099_-\|glutathione-S-transferase-family-protein	gnl\|CDD\|223512	COG0435, ECM4, Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	7.00396e-159
NZ_CP011125.1\|WP_053237743.1\|9227366_9228173_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|367049	pfam02353, CMAS, Mycolic acid cyclopropane synthetase. This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.	5.42201e-23
NZ_CP011125.1\|WP_053237742.1\|9226314_9227187_-\|acyl-CoA-thioesterase-II	gnl\|CDD\|224857	COG1946, TesB, Acyl-CoA thioesterase [Lipid metabolism].	1.14309e-137
NZ_CP011125.1\|WP_157068918.1\|9232602_9233922_+\|transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	7.87484e-10
NZ_CP011125.1\|WP_053237741.1\|9225369_9226143_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.000939874
NZ_CP011125.1\|WP_053239103.1\|9240860_9242021_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341462	cd08183, Fe-ADH-like, Iron-containing alcohol dehydrogenases-like. This family contains iron-containing alcohol dehydrogenase (Fe-ADH) which catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions. The protein structure represents a dehydroquinate synthase-like fold and is a member of the iron-activated alcohol dehydrogenase-like family. It is distinct from other alcohol dehydrogenases which contain different protein domains. Proteins of this family have not been characterized.	0
NZ_CP011125.1\|WP_053237740.1\|9222715_9225337_-\|PAS-domain-containing-protein	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	9.15233e-57
NZ_CP011125.1\|WP_053237752.1\|9242020_9242365_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	3.92287e-22
NZ_CP011125.1\|WP_053237745.1\|9229198_9230884_+\|CHASE-domain-containing-protein	gnl\|CDD\|377162	pfam03924, CHASE, CHASE domain. This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases. Predicted to be a ligand binding domain.	6.63694e-48
NZ_CP011125.1\|WP_157070073.1\|9220369_9222307_-\|VWA-domain-containing-protein	gnl\|CDD\|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	5.87206e-08
NZ_CP011125.1\|WP_157070080.1\|9243737_9244184_+\|hypothetical-protein	gnl\|CDD\|379608	pfam14433, SUKH-3, SUKH-3 immunity protein. This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems.	1.77454e-14
NZ_CP011125.1\|WP_169791697.1\|9231053_9232079_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	6.55513e-117

>NZ_CP011125.1|WP_157068918.1|9232602_9233922_+|transposase
MAKRTYRTVEIQHVDASKLATALGACCIVAIDLAKTKMFAGFASAAGRCIEIVRFEHPKQTRLFLELLCRLRELGVALEVAMEPTGVYGDALRYQLTLRDIPVFRVDAKKVHDAAALLDGVPSLHDAKACTLLAHLHAQGISKRWKERSAVQRAMRSLIDERDLYARPFETAYGRLEALVARHWPELSQHLDMDAAWHLHLLCEMPGPAEVRARRGDAVALLRRVSRAALSFERIEQIVGCAVSSLGESMHDQERSFLRSLARHMLALREHIRDVDKRIEAELANHRELHSIRAAFGAVTTAALVADLGNPADYESSASFEKAMGLNLRVQSSGNNAGQHTIHITKRGPGRARRYLFLAALRFVQSDPVAREWYRARKGYRADIKLKAVVALMRKLARAMVHVARGAPFDATKLFDTRSMTAVTASPSRDAGQSSLAGS
>NZ_CP011125.1|WP_169791697.1|9231053_9232079_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MSASSAWSLGWREDDLAARFPRVIGRSERTNELRRQLAAAAGCDATVLLRGESGTGKEVAAWSIHEASERRRGPMVVVDCSAIASELIESELFGHERGAFTGALGPRAGLFETASGGTIFLDEIGELPLAMQPKLLRVLESRTVRRVGGQKNVAIDVRVVCATHRDLRAEVRAGRFREDLYFRLAVLSVELPALRARREDVPLLIEHFLQQQSASAAAVMARIARERRHELLQHAWPGNVRELRNHVERCAAFGRWVPLDGDVEPELAREEPSGEHRVAAILGVDGSKAYADEKQKWVSLFERAYLEELLRVHDDNVKAAARTAGIDRAYLYRLLHRHALR
>NZ_CP011125.1|WP_053237745.1|9229198_9230884_+|CHASE-domain-containing-protein
MPHDSAPRRRSSTPWIVLVASIALVTFAAVAAAQWVESQASLRRERATAEAVRIVERRMDAYVALLRGVAALFAYDERVDGEGFARFVEHLQVREYPGIQGLGWSERVEPEQDGAVLARIDGAASGLWPERPHDRERHAIVFLEPRDVRNRAAIGFDMHSEATRREAMDRARDEGVPAATGAVTLVQEIDGDVQPGFLIYVPVYEGGDVPRTLEERRARLRGFAYAPFRAGDLFRAMFPDGFGAHLTIHDGTEAHAARELFEIEASGHTASPSVQRMEIAGRPWTLVVRPRGDRVSDARVVGIVIALVGALLTALAFRSAWAEARARERAEEALAIEARHAQFRETFLGVLGHDLRNPLSAVRMTAQALQRAPSIDETSRRALERIVRSADRAIRMVSQLLDVTRARLGGGLPIEARTVALAPLLREVVDELCSTHDARFELDVDDRLALHADPDRIAQVLSNLAGNALTHGEPPLRLSAHAEGRMARVEVANGGAPIPPHVLATLFDPFVRGAQRGGNREGLGLGLYISQQIAIAHGGSLDASSDAERGTRFVVRLPLAG
>NZ_CP011125.1|WP_053237744.1|9228142_9229099_-|glutathione-S-transferase-family-protein
MGHLVDGKWSTEWYAPDAEGRFQRPRTKFHGWIRADGSTDHAPVAGRYHLYVSTACPWAHRTLITRALRGLEHAISVTVVDPHMGPDGWPFDARDPDPLGPSQFLRDVYLRAKRDYTGRVTVPVLWDRERATIVNNESREIMRMLDVECEPLATRGPSLAPPALRARIDEVLDAIYEPINNGVYRAGFAKSQKAYEDACRELFAALDRWNEVLERQRFLCGDAMTEADVALFTTLLRFDLVYYAHFKCNLHRIQDYPALWGFVRDVYQTPGVRETCDLDAIKTHYYWSQDAVNPTRIVPLGPTLDLDAPHGRTARTSA
>NZ_CP011125.1|WP_053237743.1|9227366_9228173_+|class-I-SAM-dependent-methyltransferase
MTSRASFAGSRAEHHYDLRGTDALPTDGPDPVVNMGLWRARPATLHAANLALFDRVIELAEIRGGTRVLDVGCGFGTAAMRVAERTDAAQIVGINVSTVQLRTAYELTRARGLEQRVAFVAASATALPFADASVDHLVSIEAAFHFDTRDAFFREAHRVLRPGGTLALADLVITPPRNRVQEAMLVQLSRALAFPLGNAYGLPEYAARVARAGLVVEHAESIAHDVVPAFRRWMLRHSWRHRALAADLAAWPYLVYPWDYALVRAVRP
>NZ_CP011125.1|WP_053237742.1|9226314_9227187_-|acyl-CoA-thioesterase-II
MSKVLDELVKLLALEKIEENLFRGQSQDLGWGRVFGGQVLGQALSAALQTVPADRAAHSLHAYFLRPGDVSKPIVYDVDRIRDGSSFTTRRVVAIQSGQPILNLQASFQIVEEGFSHQDEMPEAPPPESLKTEQERIASYAGRLPRGLRERAVAERPFELRPVDEADDPFVPAPRPPMRMVWLKTVAKLPDDRALHRYLLAYASDYSFVTTSLRPHGVTWLTPGMQVASVDHVMWFHQDFRVDDWLLHVIDSPAAHGARGLVRGRVFTRDGRLVASTAQEGLIRLRPQQP
>NZ_CP011125.1|WP_053237741.1|9225369_9226143_-|hypothetical-protein
MDTTDESSDTPKRSKRAVKAETTSAEASLATASETTEAAPSAETPAAPPAEITETAETEARVDAAPATTEPTESATAESAMAAESTSSPGTVPAEPISDRRRLQAELEALEKKQAELRRALTIADHPDLADAIRVVEGRAYAVTRAEAKMAQGLSKGEERRRETLEKKLSAARAKRDEIDAQIAELERELAPLGEERMRAFEQERRAALEALVSVLGAHDAAFAAAGIDVAALVPELARWTPELRTVAEEIVARGKA
>NZ_CP011125.1|WP_053237740.1|9222715_9225337_-|PAS-domain-containing-protein
MSQHSEPGGKGAPDARPLASIVADLQEAEAVGAELDREDLRAALAQAPVGIAIWRGPEHVYRFVNRRYAEMFAPRALVGRTLREAFPELDGDAYALWDRVYSTGEPFVAYEHRGDYDRRGTGVREEAYFTFSLHPVRRASGEVDGVVAIATEVTEAVQIARASAKKDQAHLEGIAETADALRRSEEQLRVIVNTVPALVAYIDRDLVYRWCNESYEQWFGPVARTYVGRAMRDVVGERAHEIVRPRIDAVLRGERVAFEDEIPYAHGGKRWVDATYAPVLGPRGDVEGFVALVHDVSDRRRAERALDLLARASVELGASLETDVVLSDLTRVLVPDVGEWAAVYLRGEDGRTTLAALTHRSPEKAALIREEVARYPRPDDATCGHAAVIRTGRAEIYPRIDPATLDAGATSADHARLLSDIAPRSMMIVPLRAQGRVLGALSVGRTESAVAYDAADLALAEELGRRAAAALENARLFALAQTERVRAEEANRAKDEFLAMVSHELRTPLNAILGWARLLEQGGLDEPKRGRAIHVIARNARAQAQLIDDLLDVTRVVSGKIRLEVRRVDLARVIDAALESMRPAADAKQLTVEVQRDPAASEMLGDADRLQQVVFNLLSNAVKFTPAGGTVRVRSERIEHALRITVTDSGEGIDPSFLPYVFERFRQAEVGTTRSKGGLGLGLAIVRSLVELHGGTIGAHSAGRGRGATFTVVLPIAPDRAEPRRGPPSSPAMPAIAPPASTPSLRGVRVLVVDDERDARELLRTVLEGAGAEVTTSASVSEALARIAARVPDVIVSDIGMPGEDGYALIETLRRRAAEDGGRVPAVALTAFARTDDRTRALRAGFDVHVAKPFDPVELVLVVASVASRAKPT
>NZ_CP011125.1|WP_157070073.1|9220369_9222307_-|VWA-domain-containing-protein
MIVVVAWSPRAHAQTLDAPEDVREVAHDVRVTFAEGVAEIALRIELARDGTQRAEIGYTLALPRGAEAISLEVCRAGGGCRALSSSITRGSHVDPYAVALHGAPRGRTSRPIASASWRRSALTIRAAPVGDGARLVLAVRYAAPLVVRGGTSSLVLPARDADPRLVPASITLVAPGHDTLSVSGGAPGEDAVISARVASPLRVLADVECIGARCAHAHLVEPRRVARHDVILAIDASPSMLDVPVERVETALRTVLASLAPGSRVRVLRFGARARWETSTWCAPDTLDAARLASELPGALGSRTLFDLPPDALDDARSPLVVVIGDGWLDRADLAALEARGARVVIANVSDAPFGGVTLRAASATTSTMTLSLGASFAGAGFDLASIVAEPAPRARIELRGEPAIDLATVPTGEALTFFAPGRAARLVVGTRTSRASSPSDALRAVLAQEGSFDALALDRRVLGDLDKWTRPRRRPPPVPGGIGGVHSWITAMPIGHGLYARSARPPLLRVPAPARIRATASAETLRRMVRRQLGPRVRGCLAGARAGRPDWHAHVTLDLSLAHREVLGARVSGENVDASLASCILAGVDDLQVPRFDGRIDVSYPFRAVAIARPAALPLDDATSSVLDTIAPDAPVAPDVLLTP
>NZ_CP011125.1|WP_053237738.1|9220050_9220380_+|hypothetical-protein
MSGELLDRFTVGALDVRVTRSCARRDLYDVRAPGALPLALRSAMVARAEGATLAGNDLLWVIDVPHVHRITVSAASGRIAVLPRMETERPDQRAAVMALCEWLEGALTA
>NZ_CP011125.1|WP_053237748.1|9236528_9237071_-|hypothetical-protein
MLALALAACGGDDDGATETDAGGRVDSGSMDSGTQTDSGTQVDSGEDEEVDSGSEPDSGGGDDAGSDAGGDSDAGSDGGGGDVCAPPGIGAACDAETGECQTGLRCYTGSAGDFCSVDRAPDCGGFAHTRCPASAPYCLRPIGSSLGACATEQEAICICAVASEKIQPGEGTEGCPTPPR
>NZ_CP011125.1|WP_053237749.1|9237211_9239407_+|hypothetical-protein
MRPALARLACALVVLTAACTVPMDPPDEGWRDAQIDAQPEADAGPPPDDAAVACDPEGSRIGETCTADDDCSDACFCNGAERCVEGVCAAGDDPCADGVVPDGAPSCVVAGCVESARACAAMPDHTQCDDGEPCNGAETCSASLGCVAGEEPSCDDDDSCTIDACEAGVGCVHDPRDLDADGHPDVRCGGDDCDDDPRTGASTYPGVGELCANRRDDDCDGALDFEDEDCVPSNDDCATAEPLPPNDVTVSGSTRGLDGDLDLSCAPAGGADAVYRIQLPAHTDLHVEARSGNTTISVALRPLDECITGPDLRCSTRVGPSFVGRNLPPGDYAIIVRTPLPAPFTLVVDVEPPSAPAQNETCSATTDRLESGVTVSGRFDEVGDDVQPACREDGGLVADAVYRLRLDAPSDVVISASTDGLTGVYLSLVEGCDALTDSISCVVDRAAIVRRRALPAGTYFVVVEPEDPTVITYELVAHVTPAAPAAPGDACGSAIDVPVDGRVVIPVASLLQDGGTSCGGASGAERDAVLRLTLTQRRDVTVTATTTTGHASYVALRTECDDTWSELACRAQPLTTEALAAGTYAIVVTTAATSGDLTIDVETSAPSESVPGDHCEDAVDVSAGARIDATFAGAADDLRAGTCASFGRPDAFYRLSLATERRVLVFAESLVPGLVSVSLHTGGCAGPELLCRTGTTAAFERVLPAGEHYLAVEGDQTTPGAYRLRVFVEAP
>NZ_CP011125.1|WP_053237750.1|9239504_9240080_+|hypothetical-protein
MRPALLTTALVLASCASHSRVACTIPPVTWLPAAEPPSEPPAAPEPTPPRCLGVELAVDVIAPDDSSRRRITLHCRADEAVLSVVSHCPDCESTPSELTLDVAQADALWDELEPALETAECPDDPGRATLELRSPARSLSCHSADLPPTWRALRETLERTFRAVVDAHRDWSPYSADCWPHSADCWPDSAD
>NZ_CP011125.1|WP_053237751.1|9240085_9240718_-|glutathione-S-transferase-family-protein
MSTVQIVGRSSSHFTRMCLIFAHELEVPFELVPVHDMTRLDAEAYGGHPALKVPALRCEDRLVFGAQNVCRVLAERAGATERVVWPEQLRDDVSRNAQELVWHCMSAQVQLVVGTGLAKLPADNLYFTKARGGFEGALRWLDEHLEAALSALQAQRALSVFEVSLFCLIEHLGFRPTLPLEPYPSLVRFARELGARPSAERTAYRFDAPA
>NZ_CP011125.1|WP_053239103.1|9240860_9242021_-|iron-containing-alcohol-dehydrogenase
MFELATAGRIVFGDGAIAKLPSIVSSLAGGEARCLFVTGARVERFAHVRQALEGAGIAAVPFAVSGEPTTELAREGTALARRERCSIVVAIGGGSVLDAGKAIAALVTNEGDPLDYLEVIGRGLPLTRAPLPFVAAPTTAGTGSEVTKNAVLADPTQRVKVSLRSDAMLPRVALVDPELTWSVPPAVTASTGLDAITQCLEPFVSSMASPLTDPFCREGMRLGAGALRRAYAKGDDREARRDMALCSVFGGIALANAKLGAVHGFAAPIGGSFESPHGAVCARLLPLVIETNVAALRARAPESPSLARYEEAARIVCGRADAKIEDLIAWGHDIARDLAIPALSTYGMRASDVETIADKAAKASSTKGNPIVLERAELIAILERAL
>NZ_CP011125.1|WP_053237752.1|9242020_9242365_-|antibiotic-biosynthesis-monooxygenase
MLRGMLIVHVHVRVKPEHVDAFVAATEDNARASLQEPGILRFDLIRDAGERDRFVLVEVYRTDDDPAKHKQTAHYAKWRDAVEPMMAEPRRSVKYADVFPREQTAWATSGYTRS
>NZ_CP011125.1|WP_157070078.1|9242451_9242625_+|hypothetical-protein
MDEPIDLPDGSEIELEIVENDDEWSPELDAELLARAEAAARGEVVTAADAIARLRRR
>NZ_CP011125.1|WP_053237753.1|9242624_9242942_+|hypothetical-protein
MREVVLSADALRDVEDATSWWDEHRPDARGLVVDELAAALDHLGEHATTLPVFQRIGSSFVVRRYLLPRTRRHIYFTVEADRVLVLAVWGSVRAVLPRLRARTRT
>NZ_CP011125.1|WP_053237754.1|9242949_9243666_+|hypothetical-protein
MKSARELAAGVLDDVSAREHDAARGTFDGLDVEIRLVDRGVGSSRDPWTEIVVLGQAVRDDLHLGVIAQTDRDAKDVEEEQLGTDLVLDDPQFDPVFLVEAGPADVVKSLLDARVRKQMLALKPLGLHTRPEGLVLDKPSWLEDPKVVRALVILAVAITRRVPHAFEAPDRDARSRSAYRDGPSATSMGRSRRDEVADVKARKQLRDERNAQRGCYTVIAILAIVAILSMLSLIFAQE
>NZ_CP011125.1|WP_157070080.1|9243737_9244184_+|hypothetical-protein
MPETEVVLRGAGWYPGRSADLTSYAGCLRAWGLPWIDVAAPFLRELGGLRIPCGSGVLSIDPCALLAYAQCCEDIDWIRAFGDRVDEPVIAIGSISHGQILQGSSGRVYAHYDGLVLLAGATSDAAIDALVRDVPLPPADVLPAPDDE

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Crispr_ID: NZ_CP011125_38

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_38

9386410-9386538

Orphan

Consensus_repeat	Method
CGCGCAGCCCGACACGCGCGCGCAGCGCGCAACCCGCAAGCGGGTCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_38

>merge|NZ_CP011125|38|9386410-9386538|CRISPRCasFinder
CGCGCAGCCCGACACGCGCGCGCAGCGCGCAACCCGCAAGCGGGTCGAGGACCCCGCGCAGTCGAGGGGTCGAGAGAGACGCGCGCAGCCCAACACGCGCGCGCAGCGCGCAACCCGCAAGCGGGTCGA

>NZ_CP011125|38|32|9386410-9386538|CRISPRCasFinder
CGCGCAGCCCGACACGCGCGCGCAGCGCGCAACCCGCAAGCGGGTCGA	GGACCCCGCGCAGTCGAGGGGTCGAGAGAGACG
CGCGCAGCCCAACACGCGCGCGCAGCGCGCAACCCGCAAGCGGGTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_169791706.1\|9393672_9395844_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379232
NZ_CP011125.1\|WP_053237873.1\|9380220_9380892_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237174
NZ_CP011125.1\|WP_053237880.1\|9389088_9390786_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224423
NZ_CP011125.1\|WP_169791707.1\|9398189_9399203_+\|sulfotransferase	unknown	unknown	gnl\|CDD\|379204
NZ_CP011125.1\|WP_053237881.1\|9390871_9393337_+\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NZ_CP011125.1\|WP_053237875.1\|9382103_9382739_+\|XylR-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|198057
NZ_CP011125.1\|WP_053237887.1\|9399251_9401057_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053237869.1\|9375473_9376967_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791705.1\|9380914_9381874_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237878.1\|9387501_9387909_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|223796
NZ_CP011125.1\|WP_053237876.1\|9382735_9383008_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_083458359.1\|9395952_9396924_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237877.1\|9383064_9386298_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP011125.1\|WP_157070455.1\|9386594_9386849_-\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|240828
NZ_CP011125.1\|WP_053237870.1\|9377143_9377677_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053237871.1\|9377827_9379111_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225176
NZ_CP011125.1\|WP_157070146.1\|9396863_9398111_+\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|226651
NZ_CP011125.1\|WP_053237868.1\|9374137_9374623_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239311
NZ_CP011125.1\|WP_053239112.1\|9374633_9375470_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP011125.1\|WP_075097743.1\|9388094_9389084_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053237887.1\|9399251_9401057_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.38053e-83
NZ_CP011125.1\|WP_053237873.1\|9380220_9380892_-\|hypothetical-protein	gnl\|CDD\|237174	PRK12696, flgH, flagellar basal body L-ring protein; Reviewed.	0.00946199
NZ_CP011125.1\|WP_053237880.1\|9389088_9390786_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	5.25134e-21
NZ_CP011125.1\|WP_169791707.1\|9398189_9399203_+\|sulfotransferase	gnl\|CDD\|379204	pfam13469, Sulfotransfer_3, Sulfotransferase family.	7.56405e-28
NZ_CP011125.1\|WP_053237881.1\|9390871_9393337_+\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	0.00234741
NZ_CP011125.1\|WP_053237875.1\|9382103_9382739_+\|XylR-N-terminal-domain-containing-protein	gnl\|CDD\|198057	smart00989, V4R, The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons.	8.75069e-07
NZ_CP011125.1\|WP_169791706.1\|9393672_9395844_-\|hypothetical-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	3.33841e-06
NZ_CP011125.1\|WP_053237878.1\|9387501_9387909_+\|RNA-binding-protein	gnl\|CDD\|223796	COG0724, COG0724, RNA-binding proteins (RRM domain) [General function prediction only].	4.00445e-30
NZ_CP011125.1\|WP_157070455.1\|9386594_9386849_-\|RNA-binding-protein	gnl\|CDD\|240828	cd12382, RRM_RBMX_like, RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins. This subfamily corresponds to the RRM domain of hnRNP G, also termed glycoprotein p43 or RBMX, an RNA-binding motif protein located on the X chromosome. It is expressed ubiquitously and has been implicated in the splicing control of several pre-mRNAs. Moreover, hnRNP G may function as a regulator of transcription for SREBP-1c and GnRH1. Research has shown that hnRNP G may also act as a tumor-suppressor since it upregulates the Txnip gene and promotes the fidelity of DNA end-joining activity. In addition, hnRNP G appears to play a critical role in proper neural development of zebrafish and frog embryos. The family also includes several paralogs of hnRNP G, such as hRBMY and hnRNP G-T (also termed RNA-binding motif protein, X-linked-like-2). Both, hRBMY and hnRNP G-T, are exclusively expressed in testis and critical for male fertility. Like hnRNP G, hRBMY and hnRNP G-T interact with factors implicated in the regulation of pre-mRNA splicing, such as hTra2-beta1 and T-STAR. Although members in this family share a high conserved N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), they appear to recognize different RNA targets. For instance, hRBMY interacts specifically with a stem-loop structure in which the loop is formed by the sequence CA/UCAA. In contrast, hnRNP G associates with single stranded RNA sequences containing a CCA/C motif. In addition to the RRM, hnRNP G contains a nascent transcripts targeting domain (NTD) in the middle region and a novel auxiliary RNA-binding domain (RBD) in its C-terminal region. The C-terminal RBD exhibits distinct RNA binding specificity, and would play a critical role in the regulation of alternative splicing by hnRNP G. .	1.30044e-27
NZ_CP011125.1\|WP_053237877.1\|9383064_9386298_+\|PAS-domain-S-box-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.45527e-45
NZ_CP011125.1\|WP_053237871.1\|9377827_9379111_+\|hypothetical-protein	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	5.02711e-05
NZ_CP011125.1\|WP_157070146.1\|9396863_9398111_+\|dienelactone-hydrolase-family-protein	gnl\|CDD\|226651	COG4188, COG4188, Predicted dienelactone hydrolase [General function prediction only].	2.39229e-13
NZ_CP011125.1\|WP_053237868.1\|9374137_9374623_+\|peroxiredoxin	gnl\|CDD\|239311	cd03013, PRX5_like, Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 suggests that it may have an important antioxidant role in organelles that are major sources of reactive oxygen species (ROS), as well as a role in the control of signal transduction. PRX5 has been shown to reduce hydrogen peroxide, alkyl hydroperoxides and peroxynitrite. As with all other PRXs, the N-terminal peroxidatic cysteine of PRX5 is oxidized into a sulfenic acid intermediate upon reaction with peroxides. Human PRX5 is able to resolve this intermediate by forming an intramolecular disulfide bond with its C-terminal cysteine (the resolving cysteine), which can then be reduced by TRX, just like an atypical 2-cys PRX. This resolving cysteine, however, is not conserved in other members of the subfamily. In such cases, it is assumed that the oxidized cysteine is directly resolved by an external small-molecule or protein reductant, typical of a 1-cys PRX. In the case of the H. influenza PRX5 hybrid, the resolving glutaredoxin domain is on the same protein chain as PRX. PRX5 homodimers show an A-type interface, similar to atypical 2-cys PRXs.	8.50972e-82
NZ_CP011125.1\|WP_053239112.1\|9374633_9375470_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.24852e-06

>NZ_CP011125.1|WP_053237877.1|9383064_9386298_+|PAS-domain-S-box-protein
MRAQATLVRPLAGVPALAVDLPRVARAIGVIVALVGTAMLASWWARAPLGPRAHPAMMPTTALAAALAGASLALRAASGPSGTTRVVISRVLALAVTAIGALTLAQYLLGIDLALERIACFGRAAGSLLPGPNTALAFTALGIALLAIEPRRSVGTRVAAVAAAIGAVIALTAFYGHVYGAAALHEATRSLRTTGMSVLTAIALLALSVGVVIARPRPGLARVLGGSRTAGHMARRLFAALFAVPVLGLLVTVGHTRGLYTQLESAALFAVAATLLGAAWIASTARALDRADEARDVAAAEAAKWKLFFEHADWGAALARPDGTLELVNDALAAQRGSSVDALRGLAFDALHTPDHRDEARAMLERNAANGHARIASEHVRSDGSTFPVRIAATALRDRAGRLLFHALQVDDVTEERAVEAQRARFASMVESAEDAVVAITVDGRLTEWNPAAERLYGWSASEMIGETYAPLVPPELHDDTERLFARLRRGLRVAPYETLLMHKDGRRIPVSVTVWPVIGRDGRVLMISASARDISARKEMEDELRRASETERRLRDELERVTRASSVVAEELAALPDTSRASLLHTIALQAQLLTCADAVAVAIGSDPGQRFEDWAVIGIDPELERELGRPHAIGTLGSVAASGEIVLTGDVATHAAFGGLRDGPPRLHALAAVPIVHRGRPVGSLFVASTQKGEVFAEADVRVLRMLAARVGPAIETARAYEAVSLKSAWLSAVIEQMPEGVVLTDEHGRIVSQNEAARRLARDGASGAAAIDTLYEMVDARGAPLPETERPLSRALERHESAAGIELAVRTTEGRAVPILASATPVRVGERVVGAVLVFRDISVVKELERMRDEWSSIIAHDLRQPLSVISMSTGLLRHVITLRPSERKTLDRIQSSTRTLTRMVEDLLDASRIESRRLSITQREIDVGALAREVVERNTNLLAGHELQLVEHGTATVRGDAQRLEQVLVNLISNAHKYGDPGTPIRIEVLADAEPNEVDVLVSNRGRGIAPEELPHVFDRFSRSRAARSSKTEGLGLGLYICRGIVEAHGGRIRAESTPGDTTTFRITLPRIA
>NZ_CP011125.1|WP_053237876.1|9382735_9383008_+|hypothetical-protein
MSGFAQRTLPQGVQLGKISREVFDALARFTSFPWPVMQAQCRREELDPTALTKSDVERLLPHLATAVARFTSPEKGEQVAEALRAIVNAS
>NZ_CP011125.1|WP_053237875.1|9382103_9382739_+|XylR-N-terminal-domain-containing-protein
MLKSVRVPTPMEPPFAQAEQYVGAMFSRMQREPENGSVRIGGERYVLMRCESLYLSWFDALEETFGAETARAFVYNTAREIGRSDARAFVARLGGEEGVDRLAAGPVHFAHAGWAIVEILEDSAPAPNDSYFLHYLHPNTFETEVLASQKRRTADTACLFSAGYSAGWCSEAFQIDVHGRELRCLARGDERCEFIMAPSSQLDAHQHRLAR
>NZ_CP011125.1|WP_169791705.1|9380914_9381874_-|hypothetical-protein
MLVALAGCGESTTSLLVVVTADPDVRERSASVRLQVTGGHDGDTSELDETHQTNEDAWPLRAVIVPMHGDASRPVDIALEALDANERAVARIRAAPAFEAGRTRVVALHFEASCLGVLSCAAGQTCSEGRCVAVPRQTPDAGVPSMRDDGGAPAPRVDAGPSCRAVTSYADVDGDGWGDDARSRSSCEVPAGYVSRAGDCDDTCAQCTPRGGEICDGARDEDCDGRVDEDCECVIARTRACPGGDDVCVPGVQTCLLGRWGECDGRVDRRDEECNARDDDCDGRIDEDLRRGCGRGCHSTCVLGVWGPCRDGGERCDDD
>NZ_CP011125.1|WP_053237873.1|9380220_9380892_-|hypothetical-protein
MTWRTGVLGIAIVLAGACGARDTAPPPEPPVPVPVADTPPPHGPPIPGPTARSIVRTERPFAVTGALPGAEELVERARQHASVCYAQVPSPEGVMELAIDVADDRVRDVRVVRDELASSTVLACLRERVLAMPVQGSSAASIVVAWRFASAPIDVERDCSEDRECVMVSGVCGEPVSVREAVRDTAQARYRQLSAVATCAGNVPAVTAVARCREGLCTAVPVP
>NZ_CP011125.1|WP_053237871.1|9377827_9379111_+|hypothetical-protein
MTKPLLELLERASLDALAERFRSDEETNLPALFPLETLALLRAISNEAPLDTLDADDVERPVVVVVHGILGGHLAERSDPSARIWCHAGRTVTGSVARRLALADASWARPHEESDVVPERAPLYLAYGPAITAWQLCGMHVETITYDWRRDVRDEARRFGDQVRALRAKHGRPMILVAHSMGGLVASAWAQRSDADLDAFSRVAFVAVPLGGSFDAVAAHLGEPWLMHALGAASIDETFDDVRAMASSWPGLVQLFPHGAVLDAHLVDDETCWEPGRAPRALLRTMRDALHDTLFDSPLVQRAVRFYSSWYPTKTGVERASNGRLRIGGYGAGDFVVPLASLRAGGDAPTLRTTVWHPQTVVDPVVIAKVLSWGYDSAAALVGAAVDEQASATPEEVTPDHDARFASMRPPQLDAPATAADEAILTR
>NZ_CP011125.1|WP_053237870.1|9377143_9377677_+|hypothetical-protein
MRNYAVQTYGQQAWSTVVERASREDREVLSGMLLAGGWVPIGVVNRAVTTLLAEHRTRDDEMRKLSAFIADNDLGTVYKMALRFGSPEFLLSRTGSLWNRYFDSGTLTPKDMGPRHWRLTLDAPVGDDVAPNQLFCGPGCPAWIEMGLRLTGATNASVRHTECRYSNGSSCSYVVTW
>NZ_CP011125.1|WP_053237869.1|9375473_9376967_-|hypothetical-protein
MFLQNAGRIGNVPKKKFLYSRKGPWPQPSPTEPLGTAPEVLHLPWQEVLDFQLHIGLRYMRDLFVCGPAALVKALGFRELPEIPDDALASALTRGLYSRFLAPLDPPDHAKFGLDPSDGALRYKIDFTPIARVDPYEGMYVAPTITLLRREGPTSPTFVVEAVAIGETELVLRPGDGASWELAKYFVLQGCSYGTLFTEHPNVHFPYDTINAITKGSIPTDHLLFQLLHPHLRFSLVLDNAVLQSPASVISEFRHTIYDPFTARASDGLMSFFIAGYKGIRDNAAYPGYRYADSIASLGLPPTDYGRFLESYFGPFHWLTQQVVGAMDDDEMSYCEEWARWIRVWIESFPELPYRHVDAAGKQRTREKLAFALAVMLWDVTVVHSTDHHDFATDIPVEWKCFRLRVPPPVARAGSAVDRGKLSRRIDLFKSHLAHRMFFAPTTVTKLIDTEYDFGTDALRAVHNEFIERLRRVDADLPSRGIKRFIPLGEIAASIQY
>NZ_CP011125.1|WP_053239112.1|9374633_9375470_+|GNAT-family-N-acetyltransferase
MFADVVLARRIEAAESGLTREVAEAVRAHGTREVLLRALGGLGVGVWIGGSPFDKVIGWGFGDAEAEDAALRGFEDAVRSREGAVQLELSTLADLSRADALIARGYTLVGAENVLGMRLDRASLAPPAIEVRRARDDEGDAWIDTVVNGFEHPDGAHVAAHEAFPRDALVQVFHDIAGAQGYRRYLAMREGAIAGGASLRVHRDENGAIAQLAGAATLPAHRRRGVQSALLRARLRDAAEAGCDLAVVTTQPGSRSQHNAQNAGFALLYTRLVLVRGA
>NZ_CP011125.1|WP_053237868.1|9374137_9374623_+|peroxiredoxin
MTIQIGDRIPDATLMYMTADGPKPLATHEVFAGKKVVLFGVPGAFTPTCSAQHLPGYVDRHGELVAKGIDTVACMAVNDAFVMSAWGKAQEVDGKVLMLADGNAELTKKLGLELDASGFGMGTRTRRFALYAEDGVVKALEIEPGRGLTVSSAETMCSKIG
>NZ_CP011125.1|WP_157070455.1|9386594_9386849_-|RNA-binding-protein
MPARLFVGGLSDEVTEDDLAQVFGQFGRIADCIVMRDRDSRAPRGFGFVTMADRKDAPRAIAGLDGTDLKGRTLVVNVATERGR
>NZ_CP011125.1|WP_053237878.1|9387501_9387909_+|RNA-binding-protein
MSNRLYVGNLSFHTTEDTLRATFEAIGGVERVDVPMDRMTGRPRGFAFVTMASAEDAKRAIGDLDGSMLDGRPLRVNVAEDRPRGGGGGGGFGGGGGGGGRGGFGGGGGGGGGRGGYGGGGGGRGGRGGGGGDRW
>NZ_CP011125.1|WP_075097743.1|9388094_9389084_+|hypothetical-protein
MGKVGRRIAVGVGVVVGLAGAALAGFLGATPYAPPPADLHVARTAEQIERGRYIAEHVAHCTTCHSDVDRTRFSGPVVPGTIGRGGQAFGAAEGLPFDAWSANITPAALGDWTDGELARALTVGVDREGDALIPIMRYENYRHLCGEDVEAVVAWMRSLEPIENDVAEPRVDFPLTLLLRTVPDAAEPWACPDASTPREERGRYLTRIAGCADCHTRREGIEVVGEPFAGGNEMRMPNGAIHRTANLTPDRETGIGLWTEEGFVNRFRAHRGEQPIVGEDGRSSPMPWSAYAGMSDDDLAAIYAFLRTQEPVRNVVEQYTPPPAHVATR
>NZ_CP011125.1|WP_053237880.1|9389088_9390786_-|alpha/beta-fold-hydrolase
MNDLDHPSREPRRPLAPVVVGAIVLGGAGALAASSFGALPAIVTALGAALVGGLGALAIASGRRALGIASIVLGLGALACCGTSGLAYRGVQSLVPDAVALEPVAAGDRRWLRHPTLGFLVGDPGEGWQDASGSPVAAGLGIAMSAVGASEGTWMWTQPEFGANVLVAAVRPHAPPTPENARAFLEGAVTGGLRRETVELAPSRVRWDDERREIWARAHGMRASGPLGVSARYLAWIDASAQWHALIVLVTSHPDDDWTSFLLDVHTPGERWRGPGVAPPGFEVARETLLAARAAHTTELVREVASDVVPPAPGADWPFELVRYESRVGPLAAYLSRGAAQLARGEERRPAVLWLHGGFSIDEGPESVAFALAEAGIVVMAPTLRGEDGNPGRLELFLGEVDDARAALDHLRALPTVDPERVVVMGHSVGGTLALMLAETHAPARAFVSFGPMADTVDLNALFPDEQGAIYDARRVEESWVRSPLAFLADLEAPTFVVEGELGNAAQARALAAAAPAGSPLRVIVAEGDHFDLVAPVVALLTPRLRGDAPIALTQSEVDAIAAQR
>NZ_CP011125.1|WP_053237881.1|9390871_9393337_+|VCBS-repeat-containing-protein
MLRASSWCACVVLAVLLVGCDCGGGGSGACESAGDCRRGQACIDGTCVAGMDGAITPDAGSDAAVACGAGTRACGEACCGEGEVCGTDVECCARESLCGSVCCDDGQVCEQAVCRTACGERARCHDESGAEICCGDGEVCASDRCFLPDTECDDFIDCEAGEYCEPTLGRCLPQPTGEECVARPTGGEVRPTLLWHWTGAGAALPAYNQVMMAPMVASLNDDDGDGDADADDVPDVVFNTFCGVAGMGCAYGNYSSDGVLRAVSGADGSSVFDVVDPAHRTIPGSQVAIGDIDGDGWNEIVTCASDADGIGGVIAFHHDGSFYWRSSDVRVSCAQAAPSIADLDADGVPEVFVRYTVLDARSGDVESHHDCVGTGGWATNAHNPCDYTTAADLDGDGDLEIVGGNAAYRADGSVLYDRTAEFNDGYPAIGDLDRNGTPEIIVVHSAFTPAPYAGDHWLRALRNDGTDFWAAPVDINAGLAPAADVTAGTVGGGGPPTIANFDDDPDAEIGVAGAYAYAVFEPDGTRRWASISDDRSSRKTGSSVFDFDGDGVAEVVYNDHYWLRVYDGTDGDVRFCLCNTTATLWEYPVVVDVDTDGHAEIVVASNDYGSGYTTCPLRPELGECEMARITAGENVGTHGVRVFASPTRDWVGTRRIWNQHAYHVTNVSERGEIPRVERRNWQVPGLNDFRLNVQPGATNLPDPTPIELAVDLRACGASMTLYFSVRNDGWSAIPAGATIAVYAEEAGSFALITRVTTTRALLPGESERFGVPYPLDGREPGETVRFRVVANDDGDPSAEDVIECRDANNVAETTASCSILF
>NZ_CP011125.1|WP_169791706.1|9393672_9395844_-|hypothetical-protein
MRFALRLALVLLAGVAVTACGDDDAPGADASFADGPRCTTDDECDDDDFCDGVERCQPSSASADARGCIEPARGACLDGQICDGDARTCTTDCAIIDDADGDGAIAMECGGGDCDDSDARRFPGATEACDLDGRDEDCDPSTFGFRDADGDRFADATCCNGDVCGDDCDDQAPSVNPTGAELCNERDDDCDDLVDEQAGIACWADLDSDGYALAGSTEVRMCGSCGAQQTSRAPTEGAIDCDDDAASVRPGAADDQCDELDNDCDDAIDEDATSASHRLFFVDADADGFGDGSDVGMRICAASVPGRSLQPGDCDDDVATRYPGAPELCNRLADDCVAWPSGATTAPARLEEDRDGDGVSAIDATCSGGPYPKLDCADDDIRRVHCDPIPHDVATDEIQRVRAGDIDGDGDVDLVAWMTSMALAFRNDGTGTFVREPIGAADHTRAAALVDVDADGDLDVLTYASRVGWYERGAAGTWTWHAVGATADRTGTSRVPAADLDGDGLVEIVVFAADDLAVWHRVSGTWQRHPVATDAGAQLANPMLVDVDGGGSLDILVTTPDRTWVYRSSGSITGTWARSDVCLGGENDVDVFDLEPDGDLDVAFTPSGVLGSVARCTNTGTSSWTSRGITTIGYAGDLEGGDLDGDGDGDLLIAGSGPLHWQEGRPLDLERHELLPDPPGNTNMTVAIGDLDGDGDNDVVVAQRGSPARLFWLEMSGGVFSIP
>NZ_CP011125.1|WP_083458359.1|9395952_9396924_+|hypothetical-protein
MHRWTIGAALVIGTWSTWVSGAHASTDAGVCTAPTISPVPGALPVNVPGFVISARGGATSAVELVRIEEDGTETPLDIVVEWLANVTPAMRIVPSAPFEVGVRYVVRVQGCVPGSGLGEISFEYVAVDAVPVPATLGTVQISPLRRIESDVGEPFFFVDTTLVPDTDFAPWLGLYAIDFVAESELGTTPSTPRLATATRGLLERFAIACEGADPTFARVAPGAMTVRVRATSFFDETDVVEASASTTTACDESIDVTPPGVVLHDAAVGLGLDAGVAAAEGGAAGSCACRATSGSRPGTSFAATWLVLGIAIVLRRERAYSRA
>NZ_CP011125.1|WP_157070146.1|9396863_9398111_+|dienelactone-hydrolase-family-protein
MARARHRDRAATRTGILARVTSHRSIALLALFFLACGGDDDDRAPDAALVDSGTDAGPLPEPAADYFVAGPHVVASTRVTLVDDAREGRALPVEIWYPAVESARDAAAAGHAMAEFETGTRATELARLVSEAPPACLRARTRSARDAEPLADTARWPFVVFSHCHVCTRFDVAEVSERLASFGIAVVAPDHEGNTLWDELEGDAAPVGAEFLEVRVADVRFVLDAMLEDTNDALPDALRGRFDAARAGVMGHSFGAATAGVAAARDPRFVAAMAIAAPITALGGGVRAADVSTPFLFLLAREDNSITEVGNRLIRGDHSRLSGPSWLVEVDDAGHWSFSDHCGLIDLFDAGCGTGTRQTMSGVEFNYLDNSTARDIAADVAASFFARWLLGDEGATTLLARQHDSGAVTVSARVP
>NZ_CP011125.1|WP_169791707.1|9398189_9399203_+|sulfotransferase
MSYSQRAERLWNSQHDGDARQSRDDVSPHPVTFLVGAERSGTTLTRLMLDGHPELAFRYEFELAVDLVPPGEGWPDLDVYYEYLRTYRFVDPPPHIDRSLDYPSLVRSFLEQKRRADRKPRVGAVVHRNFDRLLRIWPDARFVHIVRDPRDVARSCVGMGWAGHAWSGVAPWIEAEQLWERVRASLPRQRWITVRYEDLVHDPKRELGRICRLVEIDFDDAMLEYPSRSTYRAPSPSFTEQWRKKLTPRDVQLVESRVHDMLAPRGYALSGLPRIEPSPLERAALRARCRAGRARHAARSLGVRLWVERAVAHRGGPRAWREHVQRRVDAAINAQLA
>NZ_CP011125.1|WP_053237887.1|9399251_9401057_+|serine/threonine-protein-kinase
MGDDEAPDLTEAGGHDLRLSAAEISDPQFQARYELDSLLGSGGMGEVSLVRDRRLQREIALKVLRASAAADPELRKRFQREALLQARLDHPAIVPVYDYESTDDRLYFTMKRVRGRTLRDVIDAIAEGDEATRAEWGRGRLLSAFVQVCRAIDYAHAHGVLHRDLKPQNVMLGGFGEVHVIDWGIAKHLDRASSDADGTLATIEGESLGTIGYMAPEQIVGDDVTPATDVFSLGAIVFEVLGGGPLVPPGSRSERATATLKGVELRVRERARELEMPPELEAVVLRATMREPRARYGSARELAEAVQRYLDGDRDAERRRELADECVRKAERMLAIQDERARAIVRPAAVKELARALALDPSHDVASALLGRSLLEPPAEVPAEARAVLERTQEESEREAARTGTFRYLLWLSFAPWYAAMGVRDWVTFTIIVALTAASALLMGLVWKGKLPTKAGLLAFVTSTTTLAMFSRAFSPLVIVASLAATNVMFFSGYVAPRERRAIVLFTCLAIMAPYALEMIGAMPASFTITDETIVIVPWLLGYHPTGTLVFMIAMTLTATAVPALAAGRVRDALTKAQERLAITAWQLGELVPKRKDERGE

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Crispr_ID: NZ_CP011125_39

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_39

9835668-9835974

Orphan

Consensus_repeat	Method
TCGCCGAGCCGGNGATCGC	CRT

7 spacers

The CRISPR arrays of NZ_CP011125_39

>merge|NZ_CP011125|39|9835668-9835974|CRT
TCGCCGGCGCGCCGATCGCGTCCCTTCGGTCGCGATCGGTCTCGCCGAGCCGGAGATGGCCTTTCCCCGACTCAGAGCCGGCTCGCCGAGCCGGAGATCGCCTCGCCCACTGCGGAAGCGGCTTCGCCGAGCCGGAGATGGCCTTTCCCCGGCTCAGAGCCGGCTCGCCGAGCCGGAGATCGCCTCGCCCACTGCGGAAGCGGCTTCGCCGAGCCGGAGATCGCCGATCGCCACCACGAGACGCCTTCGCCGAGCCGGCGATCGCGACCCGTGGACGGATCATCCCAATCGAGGGACCGGCGATCGC

>NZ_CP011125|39|4|9835668-9835974|CRT
TCGCCGGCGCGCCGATCGC	GTCCCTTCGGTCGCGATCGGTC
TCGCCGAGCCGGAGATGGC	CTTTCCCCGACTCAGAGCCGGC
TCGCCGAGCCGGAGATCGC	CTCGCCCACTGCGGAAGCGGCT
TCGCCGAGCCGGAGATGGC	CTTTCCCCGGCTCAGAGCCGGC
TCGCCGAGCCGGAGATCGC	CTCGCCCACTGCGGAAGCGGCT
TCGCCGAGCCGGAGATCGC	CGATCGCCACCACGAGACGCCT
TCGCCGAGCCGGCGATCGC	GACCCGTGGACGGATCATCCCAA
TCGAGGGACCGGCGATCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053238232.1\|9837927_9839157_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373017
NZ_CP011125.1\|WP_053238228.1\|9833150_9834623_-\|BamA/TamA-family-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274514
NZ_CP011125.1\|WP_169791724.1\|9840734_9841157_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238230.1\|9836061_9836832_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070326.1\|9841322_9842912_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238234.1\|9839901_9840483_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|377026
NZ_CP011125.1\|WP_169791723.1\|9824201_9826058_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011125.1\|WP_053238229.1\|9834777_9835623_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238222.1\|9828192_9828813_+\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|238317
NZ_CP011125.1\|WP_053238225.1\|9830372_9830936_-\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_CP011125.1\|WP_157070324.1\|9839237_9839816_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070327.1\|9843872_9844541_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238227.1\|9832512_9833154_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238224.1\|9829412_9830264_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|376885
NZ_CP011125.1\|WP_157070328.1\|9844590_9845316_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274357
NZ_CP011125.1\|WP_053238237.1\|9842923_9843730_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238226.1\|9830932_9832516_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|227333
NZ_CP011125.1\|WP_053238231.1\|9836890_9837931_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238223.1\|9828809_9829406_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238221.1\|9826215_9828078_-\|DUF2079-domain-containing-protein	unknown	unknown	gnl\|CDD\|370724

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053238225.1\|9830372_9830936_-\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	9.99886e-35
NZ_CP011125.1\|WP_053238232.1\|9837927_9839157_-\|hypothetical-protein	gnl\|CDD\|373017	pfam14332, DUF4388, Domain of unknown function (DUF4388). This domain family is found in bacteria, and is typically between 102 and 135 amino acids in length.	0.000106464
NZ_CP011125.1\|WP_169791723.1\|9824201_9826058_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.54646e-72
NZ_CP011125.1\|WP_053238228.1\|9833150_9834623_-\|BamA/TamA-family-outer-membrane-protein	gnl\|CDD\|274514	TIGR03303, OM_YaeT, outer membrane protein assembly complex, YaeT protein. Members of this protein family are the YaeT protein of the YaeT/YfiO complex for assembling proteins into the outer membrane of Gram-negative bacteria. This protein is similar in sequence and function to a non-essential paralog, YtfM, that is also in the Omp85 family. Members of this family typically have five tandem copies of the surface antigen variable number repeat (pfam07244), followed by an outer membrane beta-barrel domain (pfam01103), while the YtfM family typically has a single pfam07244 repeat. [Protein fate, Protein and peptide secretion and trafficking].	1.61563e-31
NZ_CP011125.1\|WP_053238224.1\|9829412_9830264_-\|Fic-family-protein	gnl\|CDD\|376885	pfam02661, Fic, Fic/DOC family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.	1.21644e-09
NZ_CP011125.1\|WP_157070328.1\|9844590_9845316_+\|hypothetical-protein	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	0.000239215
NZ_CP011125.1\|WP_053238226.1\|9830932_9832516_-\|HAMP-domain-containing-protein	gnl\|CDD\|227333	COG5000, NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms].	1.15631e-45
NZ_CP011125.1\|WP_053238234.1\|9839901_9840483_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|377026	pfam03358, FMN_red, NADPH-dependent FMN reductase.	1.31654e-09
NZ_CP011125.1\|WP_053238222.1\|9828192_9828813_+\|thiamine-phosphate-synthase	gnl\|CDD\|238317	cd00564, TMP_TenI, Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl) thiazole phosphate to yield thiamine phosphate. TenI is a enzymatically inactive regulatory protein involved in the regulation of several extracellular enzymes. This superfamily also contains other enzymatically inactive proteins with unknown functions.	3.39888e-71
NZ_CP011125.1\|WP_053238221.1\|9826215_9828078_-\|DUF2079-domain-containing-protein	gnl\|CDD\|370724	pfam09852, DUF2079, Predicted membrane protein (DUF2079). This domain, found in various hypothetical prokaryotic proteins, has no known function.	9.85118e-41

>NZ_CP011125.1|WP_053238229.1|9834777_9835623_+|hypothetical-protein
MPSTGHELPLLLLRDAPAVLACLVRDAFGVELGKGLAESSAAFHELEPAAYVADLVLVGPDVVVVVEVQRARDERKRATWPLYLASAHARHGRASWLVVVALDRAVSAWARAPIATFQGGALTPLVIGPDEIPRVRDAEVARAAPELAVLSAMAHGRNGPEVVEIGAAGLIAAAEVGRRDEDRGKLYFDAVLDALADLARAALEASMKVEGHEYRSEFARRYVAEGREEGRADGLRTAVRVLCDALGIAWTDGRERAIAALDAHALEALCARIQRERRWPD
>NZ_CP011125.1|WP_053238228.1|9833150_9834623_-|BamA/TamA-family-outer-membrane-protein
MRVPVWLVLALCLVASPSRAQTEPEPPPVSEPDPELVFLLDGIDVRGNDRTADHVIRRVLPFEIGAPLDVDDERLEQARWQLLGTGFFDSVELSIERGRERGRVVLVVDVRERNTVLLEEIALGVSEGLNGERSYGGDIYVGSTLSETNLFGTGTSLQGSFVLSMLQQGLRLRFHEPRFAGTPFALTIGAFFLNAREVYGDEDVLVTPIAPVDPEGPFGPEEVRYALVRYHRGGGWIGTGLSLDPENRINVSYQLEVVDVLSRPDAASERRGSEIVPIDFALHDGTSFVSTLTLGFAHDERDDPGLTRRGRLITLRGDLASRLLGGDYDFFRAQALWREWIALPGWEHSLRTTLFVGAALGDAPVFYRFYAADLSDLVPSRMLELNLDRRTPPNLLGTAIAELRFAQLGARVDVEYTFLIVRPNDAVRALFGFVDVGLYALADTDMFTRPIPGYPISVPIDLTFDVGIRLDTSVGVFQLAFSTLVGFVSL
>NZ_CP011125.1|WP_053238227.1|9832512_9833154_-|hypothetical-protein
MIARALIALAMLLLAPSLVHAQDESIARRAMPVRFEAGAAHVDAEASDLADAALRRRLSSGLPQTLVTRVYAFQGESTTPIAIGVRSCRITHDPWGLTYRVQIQTESSDRSETMRSVEQVIDACLDLRALRVGRARDWAPSRGQSVWLAAIVELNPLSPDTVHRIRRWLARPDGAGVEGDAFFGSFVSLFVNRRIGEAERTIRYRSAAEVRVP
>NZ_CP011125.1|WP_053238226.1|9830932_9832516_-|HAMP-domain-containing-protein
MTKSPLRLGRFERRVLAVIAAVAFVPLIGALVLGRGVLAESYRVGVNPRVRRQLEASLETYHEYLVAMRADAERSADAVAYDYRLVDALRAEDANVARDVLDAALARHEHLAAIEIVDDDGAVLAASARDLDPDHYRHLLLERDFERTADPALQHVTVRVTVAAPNEPFLAYQRAGEVVEVFRHLEASTSYVAGFYLAVYIALLLSVAVVALAIGIVVSRRVTRRIVVLADATQRVGGGDLTVEVPTDEADEVGELTRAFNAMVRDIRTSRDRIEYLQRVGAWQEMARRLAHEIKNPLTPIQLAVQQLHQSYRGEDARYRRTLDDVRDIVEEEITTLRRLVKEFGEFARLPTPELAPADLRALARDFAKGVDAAAMASEGEAPRPGLPIPSVRLDIDPDVPLPVVIDAQMLRRCLDNLVRNAVQATVSSRARGGPGSAVIVAARREGDDALLEVRDDGPGVPPGARERVFDPYYTTREEGTGLGLAIVKKVVLEHGGTISCDEAKEGGAAFRIRLPLERSSSSEGTR
>NZ_CP011125.1|WP_053238225.1|9830372_9830936_-|TlpA-family-protein-disulfide-reductase
MSDGGPTTRTILRALGFGFVLLVLGAWLAQTLFPHESPLMSQPAPPLEGRIVAGEGAESEDRVSLESLRGRPVILDFWASWCPPCRASIPILSRLAATHADAGLVTLGVNVEANQTRTFVERAHRALRSGFPTLHDEHYQMQAAYGVESLPTLVLIDRRGVVRRVEVGVPDESDLDAHIRELLAENP
>NZ_CP011125.1|WP_053238224.1|9829412_9830264_-|Fic-family-protein
MSSQNPGAEFTRLQQQAQKLDERLVVLQRLYAAAPEDARKDYNFKLDLSWIHHDSALEGVVYSIPELHAALQGQPPADASLVPTFDEIRQNKASVDLVREMATRKKLKIDLDTLKDLYVCLAPEEVEGKKPPAYRKDMPIHRLYFHEIATPDKISYKLRQFTQWVNAAETKRTTHPVRLAAKAHFQLLHIYPFPKHSGKVARLVGNLILLQNGFPPAIIHATERQRYYDALKTNDNALATVVREALMSSMESAIRYFETIAPPAPVEEPAPKPRKKAAGAKKR
>NZ_CP011125.1|WP_053238223.1|9828809_9829406_+|hypothetical-protein
MIIELAVSAAAVVVASAVARAIVQRRAAQDAEREKRLAAAARANDPRRGLRVGDVLLHVGDELWLAGMIELDEEGTLLSIFRAPENTRTAWVAQLDDEARELALLAHSDEVPEGHVPDRLPLGGRVLSLLRRGSAKVRGHGEHLPPHGPKARFTILHDAGGRVAMVIDFEGAPRLTLVGDRVERALIDVLPGGERGPE
>NZ_CP011125.1|WP_053238222.1|9828192_9828813_+|thiamine-phosphate-synthase
MRGLYAIVDPDRCAGRDPVEVASAILRGGCALIQVRAKRMPDRERLALVRAVRARAKEHGVPFVVNDRPDLALLVDADGLHLGQDDLPIAEARRIVGRMMIGRSTHDLAQLRAAMHEGANLVGFGPVFATKSKENPDPVVGLEGLARAVRVARVPIVAIGGITEASAPGVARTGVALGAAIAAIGEARDPEQTARALHLALGGGEG
>NZ_CP011125.1|WP_053238221.1|9826215_9828078_-|DUF2079-domain-containing-protein
MREWWRDARGEPSPIPWAGTRRAVHALVVIAAITFATLSLLRWHTFHNETFDLAFYARMAWGAVHGDGWNPIVGAHELGLHLAWILRPLGVIGMLFGQAPTLLVAQSIALSAAALPIARIGARHLGAPGAIVAALAWLLHPNLAHVASEEFHPGSVAVLPLAWAADALDRRSGPGIVLATLGVLLCREDLGLVTMLVGVAACGLAVRSPRSAERTRLARAGVLVAVVSLAYVLLFVLVLHPRFAPPEGSLELHFGRFGRSTTEVARYVLTHPGELIEHLSARHRVLYLALITAPCALLPLLRPGFLVIAAPVLAINLLSDFPGTTDLDSHYLTPAMPFVLASAIHGAAALPDGALLRLAPLATSAFFAHVIAGGTPLSLAFSREPFVADESTDAARRIVARIGPSASVQAPDALLPHLAERRDLRRAPPPETRADFVVLDASHRVRFAHDEDLLRTSEEPEIRAWIARDDHALVEAGGDYLLLERGRDPREGIGARAIIGHDDDRRAGRRLTGCLRLRDARLERRGSGLVLTLDLVALGACPSDLALRIGEGKRPSRVDLVANGWLSPAHFRAGDVIRSEHPLGPAEVRPGRLRVGALRSSGARPEHLDPHSLSIDAAFP
>NZ_CP011125.1|WP_169791723.1|9824201_9826058_-|serine/threonine-protein-kinase
MFQGGSAAHSRASTLTSSGQDDEDDGPTLLESRKNLQSLQPELLADRYESRSVLGEGGMGEVRLVWDRVVGREVAMKVLLPTRSNRSRAKERFLREAHVQGYLDHPGIVPVHEVGTLPSGEPFFTMKRIRGVTLHEVLEGLRKNDPNLRSRFSRRRMLSAFAKACLAIDYAHARGVVHRDLKPENVMLGDFGEVYVLDWGVARIVGTQVQRMPMALLGSITRAEQDLLGTPGYMAPEQIDRSNDADSAADVYSLGAILFEVLTHQALHRGKSVRELMISTREGADARCSVRAPQAAVPPELEAICVRATHADPLKRPQARELHEAIESFLDGDRETARRKLVADLHLRAAKETLKRASGSSGAEGATAQRDAIRGLARALSADPSNPEALQQLLDALAKPLDGKLPEEAEAEIREEEEKQHRVASRALRAGRFSWLLYVPLVVWLGPRDLVLGLTALGAIIAAVIVSWIVDLLPRPRPWMRTAVAVFAMLTIMPIASLFSPLILLPAITAASIPTFMVHLDRPGRWITTAAACIAATLPFALEIAGVIPPSVLIRDGAITILPRMTHFPEWPTRVVLLVLSMSPLITSAILVGRVRWELDAARRRVHWHLWRLRQLMP
>NZ_CP011125.1|WP_053238230.1|9836061_9836832_-|hypothetical-protein
MTEVSKTVADHLAISEQVLQAIEVLGGKVAEGIASGARIPRDVVLSAVIAWLGTHLRSAHDALRDADLEHAAELQDDRAPRDARDQITADLRGALISASSVVRGAYGESFSTAAGLEAAVEKRPDLVAAQAHRIARALRAGRAPATITEGVRVDLAALASSLEARASRLDDALSIVRREEREAQTAMSARDAALARWERTYAGVAEIFTGLCTLAGLDDLARKVRPTPRRRAGLPDDGGAPPGGGGEGDGGGGTTE
>NZ_CP011125.1|WP_053238231.1|9836890_9837931_-|hypothetical-protein
MKRALWWMAGVATVAATIALAAYLWLFEVRGRIATLSAVPFGPYVVTQHQRRTSRWLPWLPTHELEVSDASGPRWRIRVRDATPWDGFGASHWLRHDELLVEDGDTWHGHDLATGALRWRAPLHHVHDARVLPRVTLVLDGHSQLWAIDHTSGVARWARDFDEGRLDALPTLGDEIVIGTDVVDLGTGRVRLELPYAFAMAGDQLFWAEGDVVMRRPAGAPPRRVLSLSALGAVDALAVGDEVLIHLSRIAQWAPDVAVRAQPTAVRLDELTARDAAIVALGPHDDVRWTVAMAHGFWRWCAVHDPRSVVVVQTSRAAGPQYVDAAFAIDVETGTVLALDASSACP
>NZ_CP011125.1|WP_053238232.1|9837927_9839157_-|hypothetical-protein
MATEPAMSGEIPPDGVLDILREIEARRITGRLRFTATSEDGTKLTGEVELIAGQIALDQDPLPDGSDPVERLLAMRGGIFVVHQRLPVLPVSQGDDRHRVGSLSVHVPADLMNYCEQAGLTGTLKLDHEGERVELVYEAGELLAIRVDGREDGDLTHVFGWDSGRFEIAVNAKVRTLIPELPAEEARKALESDDFEAREPTTQYVRPRNPEDTGKHLMKVLEVALTTIVDQSERARPARVSPARGASKSVRPRPATMPALNAPRRREPTVRVVYLKPDDPTTAVPAGTDLSTRHVAPGHAREEALPEAQPARRKSAEHAAVEPAKPPPLRPVRKDPTPTPTPQSEPPRTAKPDRTPLRVEQPPRSSPSHRIALERETERAKHQGLTPLLWVITVVAIGLLVVGLLTQLQ
>NZ_CP011125.1|WP_157070324.1|9839237_9839816_+|hypothetical-protein
MSRLARCALVALVMVGCGPSASSSSSPDTSAGGEETAGPESCETLRAQEAETRAAVESCRASTPLPEWALRDDFEWLEEAIGARLDAARRGEEVSTGVVQMQEIAEHVWALLDEVPEAQRDAALLGRVEDGAEALMHPHTAEGRQEALAQVAGALGALRERLEPAPPADACEGPAREAAAAWMAVQAACGEE
>NZ_CP011125.1|WP_053238234.1|9839901_9840483_-|NAD(P)H-dependent-oxidoreductase
MHRPRILAIQAGLGGEDGNSAALLAHALPHLEPHADVELVTLASTPGFAPHRDALALADAFVLVTGTYWDGPSSHLQRFLEEATPSEGTALWLGKPAAVLVGAHAVGGKSVLARLQSVLATLGASIPPMSGLVVTLAAQIAIDHASHGHADDLWSTADLEIVCHNLLVATRVDRSAYRAWPVDRRDPSRRWLR
>NZ_CP011125.1|WP_169791724.1|9840734_9841157_-|hypothetical-protein
MRRSLGWLVLLVACGGSPATDPSSSTEPAAGSETEEVTPTEPAPSECPATFDAPGPSCEGERVLQCTYPEGECYCGRPPLCQGVQPPPMPPEWVCVPNRPPCPEAGTPCEGNAECAPWCCGVGVVCVDGTWQSHHFPCPP
>NZ_CP011125.1|WP_157070326.1|9841322_9842912_+|hypothetical-protein
MRVSRVLAICLALAACSNGTIEGDPRDVDGGGLGPSGDGAIARTDGGGGGGDEDASTGPAPVPVGTIAELLVPFDANRADLVGPDDHSAMYGKSPEIVPVPAGAELDLLVQDHASDETPRAMILRLTPDGDDLVITRAIEAPILDRVMGLARDESGAYFVASGVDEAGAITRENPAPGTYREGIVRVVKLDAAGAIGFDVDLDTGRADVRADAEPLINPMVAASARLAYGDGLLALVHGNNTVPDGGGVRHQKAVTTVLRADTGAVTRTSTIWCSHSFDQRLAHDGTGFVEMHLGDAYPRFVTLSRTTAERVSDAYPLFHVKGNLGDNNTHTRLGAFAAIEGAGEMGWLALFASEHTTGTGAIEGASRVAGARDLAIVRVRRDFDARRADENAFLDPALPDRLDVTSSGEARQNRLQWLTDYQTSDGGAVHAERPKLVALGGDRFVVLWERWARGDRGFAFSGTWGMVIDGSGATVVGARELTEDHLPRGDDAFRLGDDAAFVIGDREARTLRVHRVSASLEHRVVVVE
>NZ_CP011125.1|WP_053238237.1|9842923_9843730_+|hypothetical-protein
MAYREPSASEVELDRRVIVAWRGVVMATVVTVVSVITAMLAHPIALGALIIAYVALAKTASHARWVAVHVRGMHVVIRERALFRREVVRELDASDVRRVGTDERCSTTILAADVASVELTTADGSDFAITSHLLGASHARALASRIAEHFALGRTTVRERPCDPSQRAHRRLGWVGVLPVLVIVGIAWSISAYREDASEGRLALVCRERCVFGGITCLPGGTLEGSYAPGSYAVALEDRVVQVPVVAGHRTTFECRHDAGIPTPVPDR
>NZ_CP011125.1|WP_157070327.1|9843872_9844541_+|hypothetical-protein
MPKRIGALVAGAWLTLTILACMTEAPDDECDVGSEGCACTSGDGCDPGLQCVMDVCREPCDGGSCARDAGTRRDSGRPSSGTCTGTVDACWQGCISSGTSTAACRAACDLGDAYGCYALCVDNGDDTGTCRSVCGASGAIAELGCAETCIARGVATATCKGLCGLTSDCGEVGCAGVCLRQGDDVVSCKNVCGFTTERGREACHAVCGERGEAPATCSALCG
>NZ_CP011125.1|WP_157070328.1|9844590_9845316_+|hypothetical-protein
MSRLQAVRESLVAVSRRYSRVADEVEDLAHDIIVSALQRGLPLDGEVFLRSAHGAARRHAAFLARSAVRRRARELRIVAEEHDGATDTHDVEGAPLSELTPTLRTTLLLLFLGLEKAELRAALGVNDAALRKRLQSLRELGPLARPELPTPSRTPAVVRARRAQVDVLPRLEATRAGDVGRVLGASDPDGHGLIFAEALTAGRATATSGKASDAPPAGGRTRERGSSCSTVSSRTSPSSSS

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Crispr_ID: NZ_CP011125_42

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_42

9989806-9989900

Orphan

Consensus_repeat	Method
GCGGCGCGTGCGTCGACGATCCGTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_42

>merge|NZ_CP011125|42|9989806-9989900|CRISPRCasFinder
GCGGCGCGTGCGTCGACGATCCGTGCGGCTCGCTCGGCTGCGACACCGGCGAGGTGTGCGATCCGACGCGCGGCGAGTGCGTCGACGATCCGTGC

>NZ_CP011125|42|35|9989806-9989900|CRISPRCasFinder
GCGGCGCGTGCGTCGACGATCCGTGC	GGCTCGCTCGGCTGCGACACCGGCGAGGTGTGCGATCCGACGC
GCGGCGAGTGCGTCGACGATCCGTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053238346.1\|9980017_9980479_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP011125.1\|WP_053238357.1\|9997332_9999114_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173842
NZ_CP011125.1\|WP_053238348.1\|9981450_9981948_-\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NZ_CP011125.1\|WP_075098173.1\|9984854_9985382_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238361.1\|10003440_10003917_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP011125.1\|WP_157070346.1\|9999182_10000121_+\|UbiA-family-prenyltransferase	unknown	unknown	gnl\|CDD\|260125
NZ_CP011125.1\|WP_169791731.1\|9975581_9978398_-\|penicillin-acylase-family-protein	unknown	unknown	gnl\|CDD\|376618
NZ_CP011125.1\|WP_157070348.1\|10004465_10004840_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070344.1\|9985428_9985836_-\|YbjN-domain-containing-protein	unknown	unknown	gnl\|CDD\|341109
NZ_CP011125.1\|WP_075097761.1\|9982184_9983609_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NZ_CP011125.1\|WP_053238347.1\|9980565_9981072_-\|DUF4240-domain-containing-protein	unknown	unknown	gnl\|CDD\|379426
NZ_CP011125.1\|WP_053238349.1\|9984142_9984754_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238354.1\|9993895_9994807_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185695
NZ_CP011125.1\|WP_053239150.1\|9978503_9979613_+\|Mrp/NBP35-family-ATP-binding-protein	unknown	unknown	gnl\|CDD\|378455
NZ_CP011125.1\|WP_075098174.1\|9994877_9996557_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|235728
NZ_CP011125.1\|WP_053238356.1\|9996556_9997363_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070345.1\|9985936_9986164_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238360.1\|10002419_10003457_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|234948
NZ_CP011125.1\|WP_157070459.1\|10000966_10001902_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234948
NZ_CP011125.1\|WP_053238362.1\|10003913_10004453_+\|DUF3109-family-protein	unknown	unknown	gnl\|CDD\|378636

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053238346.1\|9980017_9980479_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.50177e-12
NZ_CP011125.1\|WP_053238348.1\|9981450_9981948_-\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	9.31312e-08
NZ_CP011125.1\|WP_053238361.1\|10003440_10003917_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.80139e-09
NZ_CP011125.1\|WP_053238354.1\|9993895_9994807_+\|hypothetical-protein	gnl\|CDD\|185695	cd01081, Aldose_epim, aldose 1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism; they catalyze the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate and the histidine as the active site acid to protonate the C-5 ring oxygen.	8.88724e-07
NZ_CP011125.1\|WP_157070346.1\|9999182_10000121_+\|UbiA-family-prenyltransferase	gnl\|CDD\|260125	cd13962, PT_UbiA_UBIAD1, 1,4-Dihydroxy-2-naphthoate octaprenyltransferase. Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.	1.59697e-09
NZ_CP011125.1\|WP_075098174.1\|9994877_9996557_+\|FAD-dependent-monooxygenase	gnl\|CDD\|235728	PRK06184, PRK06184, hypothetical protein; Provisional.	8.52178e-112
NZ_CP011125.1\|WP_157070344.1\|9985428_9985836_-\|YbjN-domain-containing-protein	gnl\|CDD\|341109	cd17026, T3SC_IA_SpcU-like, Class IA type III secretion system chaperone protein, similar to Pseudomonas aeruginosa SpcU. This family includes type III secretion system (T3SS) chaperone proteins similar to Pseudomonas aeruginosa SpcU and similar proteins. In P. aeruginosa, a multidrug resistant pathogen associated with serious illnesses such as ventilator-associated pneumonia and various sepsis syndromes, the T3SS allows injection of effector protein ExoU, one of the most aggressive toxins injected by a T3SS, into the cytosol of target eukaryotic cells, leading to rapid cell necrosis. Chaperone SpcU binds the cytotoxin ExoU, which is a broad-specificity phospholipase A2 (PLA2) and lysophospholipase, and maintains the N-terminus of ExoU in an unfolded state which is required for secretion.	9.43431e-10
NZ_CP011125.1\|WP_075097761.1\|9982184_9983609_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NZ_CP011125.1\|WP_053238347.1\|9980565_9981072_-\|DUF4240-domain-containing-protein	gnl\|CDD\|379426	pfam14024, DUF4240, Protein of unknown function (DUF4240). This presumed domain is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 169 and 263 amino acids in length. This domain is often associated with the WGR domain pfam05406.	2.44651e-39
NZ_CP011125.1\|WP_053238357.1\|9997332_9999114_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	3.53404e-125
NZ_CP011125.1\|WP_053239150.1\|9978503_9979613_+\|Mrp/NBP35-family-ATP-binding-protein	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	4.09131e-144
NZ_CP011125.1\|WP_169791731.1\|9975581_9978398_-\|penicillin-acylase-family-protein	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	3.99639e-79
NZ_CP011125.1\|WP_053238360.1\|10002419_10003457_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	8.15792e-31
NZ_CP011125.1\|WP_157070459.1\|10000966_10001902_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	5.95371e-67
NZ_CP011125.1\|WP_053238362.1\|10003913_10004453_+\|DUF3109-family-protein	gnl\|CDD\|378636	pfam11307, DUF3109, Protein of unknown function (DUF3109). This bacterial family of proteins has no known function.	1.2081e-08

>NZ_CP011125.1|WP_157070345.1|9985936_9986164_+|hypothetical-protein
MGATRRVKGTIRKLGIEGGVWALVTDEGDTIELIEAPAELCQNGRRAEVELEREGADVTIGMTGAAGRVRSHKML
>NZ_CP011125.1|WP_157070344.1|9985428_9985836_-|YbjN-domain-containing-protein
MRQIHRLTEPRALALQLDELGWSAARHDDRTFRCVHDTSEGELVVFVRLDQNWLIASVVPFLRTRGDNSFELSRWLLRMNRDMYQTKFAYDEDGDVVLTVELPTESLDASEIRTALSDLLQHAIRHRRTLREASA
>NZ_CP011125.1|WP_075098173.1|9984854_9985382_-|hypothetical-protein
MRIEADSVLPFSRERVFRAYRDELPDFTAYLPNVRAIEVKSRTDEGAIATLHNVWHGGGDIPAPIVKVIGGESLSWDDFAKWDQSAWTCEWNIRTSVFTEAVTCSGKNTFIELGADRTRLEIVGDISIDVKKVKGVPSFLAGSIGKTVESFLVKQITANLTSVSDALTKYLQSKG
>NZ_CP011125.1|WP_053238349.1|9984142_9984754_-|hypothetical-protein
MLARQPFVAVTVAEEPRIASAVVSGVRRTLIDLGQWPRVRARAIARMPKVRSWIDSALDGSWCPVAYHIVILESVAAEYGDDGIAAFGRARLLDNMSGGVLSPILRSWMRSYGGAPGHLLRVSPHVWRAVTRDLGRMVVVEMGERATRFRIEEMPEEARRCVAWHRFLEGYGVALLEAGSYPGAHVEISLGETPRQLEGSVRW
>NZ_CP011125.1|WP_075097761.1|9982184_9983609_+|replication-associated-recombination-protein-A
MDLFDHKEDRDREGAPLSDRMRPRRLTDMVGQRHLVAEGSLLRRAIQQDRIPSMILWGPPGTGKTTLARAVAAETKAVFVPFSAVMSGVPELRKILAEAAERKRLHGTRTILFVDEIHRWNKAQQDALLPHVERGAVVLIGATTENPSFAVNAALLSRARVFRLEPHEPSDLRALLERAMSDREHGLGKLALTVDPEALGVIAEMAQGDARRALDVLELAANDATARKVALDREAVEQALASRTLLYDKSGEEHYNVVSAFIKSMRGSDPDAAIYWMMRMLEAGEDPLFVMRRLVIFASEDVGNADPNALQIAVAADAAFRRLGMPEGLHPLAQCCTYLASTVKSNASYEAWQRAQDAVKQHGPLPVPMKLRNAATKHMKAWGYGEGYRYPHAEGGHAQGETYLPDALVGARFYEPKDIGIESRIKQRLAKLRGDERPPTEDPPRAENDARRTDRSRPDVPREEGPRTDPPDER
>NZ_CP011125.1|WP_053238348.1|9981450_9981948_-|PilZ-domain-containing-protein
MTTRNVLEMIFEYQLLRAKQDRLEVPLDDDERARLFGLGRLLTGDGSPGARTMPRLPFPKTVSFTMPGCFESGEVKNLSGNGLAIATTRPPVIGARVIVRLVDEAAGCEYFFPCRVIWARRTNLPGMGLVFDGVPTRSEYLAEESTGVWRRAMRMGDPPREANVA
>NZ_CP011125.1|WP_053238347.1|9980565_9981072_-|DUF4240-domain-containing-protein
MDEAWFWALIDASRRGCDHRSADEARGQPAVLERLLRALTPEDVAGFAHIFETLHARAYRWDLWHAAYVIEGGCSDDGFTDFRSGLIGLGREVFENALRDPLTLARLSGDSAFSQEGMRYAARRAYERITGRRLAVDVARAIEPAGEQLDEEVFLRKYAELERRFGPR
>NZ_CP011125.1|WP_053238346.1|9980017_9980479_+|RDD-family-protein
MAAEVSMDSLVPAELPVRIAARAIDVAIVVAMNVGLGQLMGFGFDWLIVGSMLVLAYFALLDAFVGATFGKLALGLRVIGPEGERVTMKQALTREAFTVLGAIPFIGPILALAAWIWIVVTIRNSPLRQGRHDALAGGTRVVRATKTVALRKP
>NZ_CP011125.1|WP_053239150.1|9978503_9979613_+|Mrp/NBP35-family-ATP-binding-protein
MAELTTESLRTALSKVVDPVFEKPMLDIGALTDLSVEPGGEVKVRAHLATPSSTVHAKVREEIERAAREAGATAVDIAIDVQVPTREVMGDDPIPGVKNVVLVMSGKGGVGKSTTAVNLTLALKRAGLRVGILDADIYGPSIPTMMGVHGHPPTRDDKKILPLERFGVKMMSIGFLLEDDKQAVIWRGPMLHSALQQFLKDVEWGELDYLVLDLPPGTGDVALTMAQKLKVSGVVMVTTPQEVALQDVYKCVSMCSKLSLPILGVIENMSYFVDSAGVRQELFGRGGGEKIAEFAKAPLLGQIPLEPPVREWGDKGMPIVQSVPDSASAKAFTAVADALIAKVANLHFERTGGTRIPAAKGPTRLRIVR
>NZ_CP011125.1|WP_169791731.1|9975581_9978398_-|penicillin-acylase-family-protein
MTYRFRLLLLSLASLPLLAACGDDDDAPPTTDGGTDAGMMTTTDLALPGLDGEVEVVYDDRGIPHIYGTTRHDVLVVQGYLMSRDRFAQMEFIRRSVLGRIAEIAGEDSLEDDVISRWEGYRRMGVEIYESLPTDDPARLSAEAFVEGINLYIDAVMRREEDPAVMGADVINLVIFGSSFGHWEPADIFALARFQSANLSFDPRDDLNRSARLALIQQAFPADDADPRIAARSGLFEDLFTQRPAREAFTDDGFPDGTTMALLPVIDPRPFGARFTPNVRAIRGAMPFLDRIEERQSRIFGDLVTRGSNNWTVSGEHTASGNPILSNDPHLSLISPAVWWYVHLNTARMGGEDMIDAQGTAFAGLPGVVIGFNRDIAWGVTTTGYDVTDAYQEQITGTCDADGNVTGGTVLWMGGQSPIAFHEETISLASGDPITVRFPYASHRPGSQFLPGSCVAVEGTTDRFVAVSVRYTGWEPSNELATFTGLMTATDVESGRAALDAFEVGSQNFMIVDRDDIMWSTQARIPVRSEMATNLVIDEETGEHTGYCPHMVVPGTGEYEWTGDLADTAIPHELAPARGWIATANQDNVGVTQDGNPCNDEHYVGAGFDYGWREARIQERLAELVERGDITTDDMIALQAETQSPLGRTLRDPIVAILGDTAAIEALGLTEDEETDLAAARTQLMEWTFETPHGVGATDTAEIADSVATTIFNAALTRIIPLALGDETERAMIGGPTSESARLIEWMLTSPSRLLSYDEAAMESVLWDDIRTDAVETKEEIVIRGVLAGLAFLTERMETSDWTEWRWGRLHTVRFNSVVPILGGDDVLSIPAENDPTYPNGFPRHGDWGNVDPGNFGLWNTESFSFGSGASQRLIVEMTADGPRAFNAIPGGQSIDPMSPHKQDEALLWIRNEQPPLYFTEQDVMSHAERELTVRPMD
>NZ_CP011125.1|WP_053238354.1|9993895_9994807_+|hypothetical-protein
MDSCDVQGFRAVRIQRGSTTLVVVPALGAKIASIHAAGREWLWTSATIPYRAPIDGASYVETADSGGFDECFPTVSPCTLPGGVTLPDHGELWAVEPEIDARDSTLSARWTGRRAKYVFERRIDVDPSGAVTMRYAATNSGNVRMPFSWSSHPLMPLTNDVTLVLPKDAITRVDAQHDIDLGGHGAEHRWPVIAGHDMTRPAALGRHYATKLFVALGDVKTVGLAVEGARLTAELEGIPDFGLWINHRGWTPFEGGTPYLNFGFEPCIGAPDSLARALEPGWENAHWLAAGETRRWAMRWTFA
>NZ_CP011125.1|WP_075098174.1|9994877_9996557_+|FAD-dependent-monooxygenase
MDTTDVLVVGAGPTGLTMACELARRGLAVRVIDRAAAPSTRSKAIVVHARTLEIFEDVGIAEDLIARGLVLRGITMWAGGEVIVSAGFEELDTRFSYLLSVSQAETEAVLAAKLESLGVEVERGTTLGSFRQDGTGVTATLRTNDGETTVRAAWLVGCDGAHSTVRETLELPFEGTTYDERFLLADVTIGWDTRDDRISTWFAEDGVIACFPMPGGRWRVIASAPAGDETEAAPTLDEVQAIFDRRTATGGVLGDATWLARFRIHCRQVARYRDDRVFLAGDAAHVHSPVGGQGMNTGIQDAHNLAWKLAMVHRGEARALLLDSYEQERHAIARSVLKSTDLATKVGTLKSSVARALRNEVARHLAGLEVVQQRIAREVSELAVGYQSSPIVREDKISMLQARIGSAAGGETPTLATMREFEHGPRAGSRAPDGRVTVAGSSGTKRLAEILDGRAWTLLLFDGRHESDAGYERYAKLCERIASRWGASVRAFVVTPRASRPAKLPESVPVLLDPDGDLEKRYGATSECAYLIRPDLYVGYRGQPIDETKLDAYLRSILR
>NZ_CP011125.1|WP_053238356.1|9996556_9997363_+|hypothetical-protein
MTRKTLRTTAELIAWMEGEYLSEALLRRATPKPTAKRAPRSVRLVLGLVVPEDPPQLQQYTLEAHGVTRWTLDGEWDVDTPLSFPDVELPDAPVAIVIDAPGRIVLTASHVEVERGATTKYRPPPRPRSDELLVWGPREISWRDVLAAVGAPASTRIVCVRHRGGVLHEQEVEGDALDARFVAPLFDRFELRTASGEPWASIHHMLAIGRTGFYLSITRAPGADDDRWARARRAPIELGECEVMSGSVRTTSSEWARWLQRSAGSSPT
>NZ_CP011125.1|WP_053238357.1|9997332_9999114_-|acyl-CoA-dehydrogenase
MPSANPLISDRFVDFLLYDVLDAPSLAALPAFADHERETFDLWLGACRRLAREVLFPTYRAMDEAPPRLEGGQVRVHPAMRAIWKELAELGVIASTRPASVGGQQLPLTVSTLASAYLMAGNLSAYGYAGLTTGAAHLIEAFGDAWTKQTFMAPLYEGRWTGTMTLTEPQAGSSLADVQTRATRTDQGHFLLRGAKIFISGGDHDVTENVVHLVLARIDGAPPGTKGISLFAVPKRRREGDAWVDNDVSISGVIHKIGWKGLPSVALALGDRNDCHGWLIGTENSGLRCMFQMMNEARLMVGVNATATASVAYHESLAYARERTQGRPLGVVDATTPPVPLVEHADVRRMLLRQKAIVEGALCLLATSAKYADLAEHATDPSLRERSRLLLDLLTPMAKSFPAEYGFESNALAVQIHGGYGYSSEYLPESWLRDQKLNSIHEGTTGIQSLDLLGRKVVAGGGAAIMTWREEILADCARADEAGVDRARTQSVRDALERVVALTGALGARGMKGDVNGMLAHSADYLQLASILAIAWMWTRMSAAIAGRDEAFARGIERAAMYWIATEVPRIEVLARLCESAEPSYVGLDPADL
>NZ_CP011125.1|WP_157070346.1|9999182_10000121_+|UbiA-family-prenyltransferase
MIRALWTLARPKGMVLIAFLPMIGFGFAYWDHGCRIPGFGALAPLGLLATVWAVPHMGTMWLNAALDRDEGQVLFGKSVPVPPGVEKYAYLTLAFSLVAAFVTDVGLGLCVLGCAMLSVLYSHPRTAWKGHAILGPLANAIGYGVLSPLGGFLLSDLPPTPRGAATLALSVTYIVAAYLAAQAFQEDEDRARGYRTLVALRGARFTLDVTRAFLALSVILTLVLAAIGWYPRLVLLAAPAFLAAERYLARWRDVPGGGDGSWAAGFFVRMMIAGLVCIVAVSADYGWSQLRGEPAGGVATASGRPATPACGG
>NZ_CP011125.1|WP_157070459.1|10000966_10001902_+|D-alanine--D-alanine-ligase
MPDDAFEEYDSDATVAAIEEALGANGYRTRRLGSGRSFLARAMQEPGDLVFNIAEGYGTRSREAHVPSALEMLGVPYTHSDPLTLALTLDKAMAKRVVASAGVPTPRFVVVENVEQLHDVPLAFPLIAKPLFEGSSMGVRKHSRVVDLYDLRELCGQLLADYREPVLVEEFCSGPEFTVGILGTGASAQVIGAMEIVPRNCAVEEFVYSLEVKRNYLEEVEYHVPPRRPDELVRAVEDVALAAYRALACRDVGRVDVRLGDDGEPKFLEVNPLPGLNPVTGDLVILARANGLGYADLIGRIVEGARERQGL
>NZ_CP011125.1|WP_053238360.1|10002419_10003457_+|ATP-grasp-domain-containing-protein
MTSLRSIAILWDSLSTTSATSAETGAAEAAAVASIGGVIDEVAHVAASLGLRVERVPLASDARTMLAQVAAIDADVVVNLAESWAGRVRNEAGVAWTLELRGCAYTGATPRALALCLEKPLTRALLASAGVPVPEGATMSDARAPWPLDVRGPWIVKPAAQDASHGVDATSVVHDERAARARVDHLITRGLGPALIERYVDGRELNVSIVELDGAPPRALPIAEIDYSQFPAELPRILTFAAKWDETSDEYRGSASVEARDLDPTRRARVEQVALAAWRALGLRDYGRVDLRLDRDGAPFVIDVNPNPDLSRGAGLCLAAERAGIGYEGLIAGLLRGAARRAHPD
>NZ_CP011125.1|WP_053238361.1|10003440_10003917_+|GNAT-family-N-acetyltransferase
MRIRTELRPTDREAIARIVRAVGVFRPDEVDVAMELVDEGLSTNADQYFFAVAEDDHGAVLGYACWGHAPMTDATYDLYWIAVDPTRHGGGIGQKLLAACEDDVRARGGRLLLIETEGTPDYEPTRRFYLRAGYPEIARVRDYYRVGADKIVYGRSLA
>NZ_CP011125.1|WP_053238362.1|10003913_10004453_+|DUF3109-family-protein
MKKALPVVNGDAARFECVWPGCGGACCKDSRPPVSEGEAARIAEAIPRVVARLRPAARRVVERGAWVTKRMKHGRPMLAIADAYCVFYAEGCALHVLGASEGDKNKYKPATCITFPLDRDDHDRWYVRQHGVENEQWTELACLDPGASSNRAVDSLREEIAFAERVEAGLETWRRPNGR
>NZ_CP011125.1|WP_157070348.1|10004465_10004840_-|hypothetical-protein
MAPRLLWIRDMQGLAALLLATMLVQGPPAALEADRERDRTPRPSFAIELELEVPTLEEVLRETFPVSELLYVRNGWVGISLTEDLAILVDVRTEGIPSSPDPARPMSRGSFSATLGIALSSWDG

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Crispr_ID: NZ_CP011125_41

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_41

9989554-9989649

Orphan

Consensus_repeat	Method
GCGGCGCGTGCGTCGACGATCCGTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_41

>merge|NZ_CP011125|41|9989554-9989649|CRISPRCasFinder
ACGGCGCGTGCGTCGGCAACAACTGCATCTTCCTGCCGTACCTCTGCACCGACGCGCAGATCTGCGCGGCCGGCGAGTGCGTCGACGATCCGTGCG

>NZ_CP011125|41|34|9989554-9989649|CRISPRCasFinder
ACGGCGCGTGCGTCGGCAACAACTGC	ATCTTCCTGCCGTACCTCTGCACCGACGCGCAGATCTGCGCGG
CCGGCGAGTGCGTCGACGATCCGTGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053238346.1\|9980017_9980479_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP011125.1\|WP_053238357.1\|9997332_9999114_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173842
NZ_CP011125.1\|WP_053238348.1\|9981450_9981948_-\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NZ_CP011125.1\|WP_075098173.1\|9984854_9985382_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238361.1\|10003440_10003917_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP011125.1\|WP_157070346.1\|9999182_10000121_+\|UbiA-family-prenyltransferase	unknown	unknown	gnl\|CDD\|260125
NZ_CP011125.1\|WP_169791731.1\|9975581_9978398_-\|penicillin-acylase-family-protein	unknown	unknown	gnl\|CDD\|376618
NZ_CP011125.1\|WP_157070348.1\|10004465_10004840_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070344.1\|9985428_9985836_-\|YbjN-domain-containing-protein	unknown	unknown	gnl\|CDD\|341109
NZ_CP011125.1\|WP_075097761.1\|9982184_9983609_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NZ_CP011125.1\|WP_053238347.1\|9980565_9981072_-\|DUF4240-domain-containing-protein	unknown	unknown	gnl\|CDD\|379426
NZ_CP011125.1\|WP_053238349.1\|9984142_9984754_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238354.1\|9993895_9994807_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185695
NZ_CP011125.1\|WP_053239150.1\|9978503_9979613_+\|Mrp/NBP35-family-ATP-binding-protein	unknown	unknown	gnl\|CDD\|378455
NZ_CP011125.1\|WP_075098174.1\|9994877_9996557_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|235728
NZ_CP011125.1\|WP_053238356.1\|9996556_9997363_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070345.1\|9985936_9986164_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238360.1\|10002419_10003457_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|234948
NZ_CP011125.1\|WP_157070459.1\|10000966_10001902_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234948
NZ_CP011125.1\|WP_053238362.1\|10003913_10004453_+\|DUF3109-family-protein	unknown	unknown	gnl\|CDD\|378636

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053238346.1\|9980017_9980479_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.50177e-12
NZ_CP011125.1\|WP_053238348.1\|9981450_9981948_-\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	9.31312e-08
NZ_CP011125.1\|WP_053238361.1\|10003440_10003917_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.80139e-09
NZ_CP011125.1\|WP_053238354.1\|9993895_9994807_+\|hypothetical-protein	gnl\|CDD\|185695	cd01081, Aldose_epim, aldose 1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism; they catalyze the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate and the histidine as the active site acid to protonate the C-5 ring oxygen.	8.88724e-07
NZ_CP011125.1\|WP_157070346.1\|9999182_10000121_+\|UbiA-family-prenyltransferase	gnl\|CDD\|260125	cd13962, PT_UbiA_UBIAD1, 1,4-Dihydroxy-2-naphthoate octaprenyltransferase. Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.	1.59697e-09
NZ_CP011125.1\|WP_075098174.1\|9994877_9996557_+\|FAD-dependent-monooxygenase	gnl\|CDD\|235728	PRK06184, PRK06184, hypothetical protein; Provisional.	8.52178e-112
NZ_CP011125.1\|WP_157070344.1\|9985428_9985836_-\|YbjN-domain-containing-protein	gnl\|CDD\|341109	cd17026, T3SC_IA_SpcU-like, Class IA type III secretion system chaperone protein, similar to Pseudomonas aeruginosa SpcU. This family includes type III secretion system (T3SS) chaperone proteins similar to Pseudomonas aeruginosa SpcU and similar proteins. In P. aeruginosa, a multidrug resistant pathogen associated with serious illnesses such as ventilator-associated pneumonia and various sepsis syndromes, the T3SS allows injection of effector protein ExoU, one of the most aggressive toxins injected by a T3SS, into the cytosol of target eukaryotic cells, leading to rapid cell necrosis. Chaperone SpcU binds the cytotoxin ExoU, which is a broad-specificity phospholipase A2 (PLA2) and lysophospholipase, and maintains the N-terminus of ExoU in an unfolded state which is required for secretion.	9.43431e-10
NZ_CP011125.1\|WP_075097761.1\|9982184_9983609_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NZ_CP011125.1\|WP_053238347.1\|9980565_9981072_-\|DUF4240-domain-containing-protein	gnl\|CDD\|379426	pfam14024, DUF4240, Protein of unknown function (DUF4240). This presumed domain is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 169 and 263 amino acids in length. This domain is often associated with the WGR domain pfam05406.	2.44651e-39
NZ_CP011125.1\|WP_053238357.1\|9997332_9999114_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	3.53404e-125
NZ_CP011125.1\|WP_053239150.1\|9978503_9979613_+\|Mrp/NBP35-family-ATP-binding-protein	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	4.09131e-144
NZ_CP011125.1\|WP_169791731.1\|9975581_9978398_-\|penicillin-acylase-family-protein	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	3.99639e-79
NZ_CP011125.1\|WP_053238360.1\|10002419_10003457_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	8.15792e-31
NZ_CP011125.1\|WP_157070459.1\|10000966_10001902_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	5.95371e-67
NZ_CP011125.1\|WP_053238362.1\|10003913_10004453_+\|DUF3109-family-protein	gnl\|CDD\|378636	pfam11307, DUF3109, Protein of unknown function (DUF3109). This bacterial family of proteins has no known function.	1.2081e-08

>NZ_CP011125.1|WP_157070345.1|9985936_9986164_+|hypothetical-protein
MGATRRVKGTIRKLGIEGGVWALVTDEGDTIELIEAPAELCQNGRRAEVELEREGADVTIGMTGAAGRVRSHKML
>NZ_CP011125.1|WP_157070344.1|9985428_9985836_-|YbjN-domain-containing-protein
MRQIHRLTEPRALALQLDELGWSAARHDDRTFRCVHDTSEGELVVFVRLDQNWLIASVVPFLRTRGDNSFELSRWLLRMNRDMYQTKFAYDEDGDVVLTVELPTESLDASEIRTALSDLLQHAIRHRRTLREASA
>NZ_CP011125.1|WP_075098173.1|9984854_9985382_-|hypothetical-protein
MRIEADSVLPFSRERVFRAYRDELPDFTAYLPNVRAIEVKSRTDEGAIATLHNVWHGGGDIPAPIVKVIGGESLSWDDFAKWDQSAWTCEWNIRTSVFTEAVTCSGKNTFIELGADRTRLEIVGDISIDVKKVKGVPSFLAGSIGKTVESFLVKQITANLTSVSDALTKYLQSKG
>NZ_CP011125.1|WP_053238349.1|9984142_9984754_-|hypothetical-protein
MLARQPFVAVTVAEEPRIASAVVSGVRRTLIDLGQWPRVRARAIARMPKVRSWIDSALDGSWCPVAYHIVILESVAAEYGDDGIAAFGRARLLDNMSGGVLSPILRSWMRSYGGAPGHLLRVSPHVWRAVTRDLGRMVVVEMGERATRFRIEEMPEEARRCVAWHRFLEGYGVALLEAGSYPGAHVEISLGETPRQLEGSVRW
>NZ_CP011125.1|WP_075097761.1|9982184_9983609_+|replication-associated-recombination-protein-A
MDLFDHKEDRDREGAPLSDRMRPRRLTDMVGQRHLVAEGSLLRRAIQQDRIPSMILWGPPGTGKTTLARAVAAETKAVFVPFSAVMSGVPELRKILAEAAERKRLHGTRTILFVDEIHRWNKAQQDALLPHVERGAVVLIGATTENPSFAVNAALLSRARVFRLEPHEPSDLRALLERAMSDREHGLGKLALTVDPEALGVIAEMAQGDARRALDVLELAANDATARKVALDREAVEQALASRTLLYDKSGEEHYNVVSAFIKSMRGSDPDAAIYWMMRMLEAGEDPLFVMRRLVIFASEDVGNADPNALQIAVAADAAFRRLGMPEGLHPLAQCCTYLASTVKSNASYEAWQRAQDAVKQHGPLPVPMKLRNAATKHMKAWGYGEGYRYPHAEGGHAQGETYLPDALVGARFYEPKDIGIESRIKQRLAKLRGDERPPTEDPPRAENDARRTDRSRPDVPREEGPRTDPPDER
>NZ_CP011125.1|WP_053238348.1|9981450_9981948_-|PilZ-domain-containing-protein
MTTRNVLEMIFEYQLLRAKQDRLEVPLDDDERARLFGLGRLLTGDGSPGARTMPRLPFPKTVSFTMPGCFESGEVKNLSGNGLAIATTRPPVIGARVIVRLVDEAAGCEYFFPCRVIWARRTNLPGMGLVFDGVPTRSEYLAEESTGVWRRAMRMGDPPREANVA
>NZ_CP011125.1|WP_053238347.1|9980565_9981072_-|DUF4240-domain-containing-protein
MDEAWFWALIDASRRGCDHRSADEARGQPAVLERLLRALTPEDVAGFAHIFETLHARAYRWDLWHAAYVIEGGCSDDGFTDFRSGLIGLGREVFENALRDPLTLARLSGDSAFSQEGMRYAARRAYERITGRRLAVDVARAIEPAGEQLDEEVFLRKYAELERRFGPR
>NZ_CP011125.1|WP_053238346.1|9980017_9980479_+|RDD-family-protein
MAAEVSMDSLVPAELPVRIAARAIDVAIVVAMNVGLGQLMGFGFDWLIVGSMLVLAYFALLDAFVGATFGKLALGLRVIGPEGERVTMKQALTREAFTVLGAIPFIGPILALAAWIWIVVTIRNSPLRQGRHDALAGGTRVVRATKTVALRKP
>NZ_CP011125.1|WP_053239150.1|9978503_9979613_+|Mrp/NBP35-family-ATP-binding-protein
MAELTTESLRTALSKVVDPVFEKPMLDIGALTDLSVEPGGEVKVRAHLATPSSTVHAKVREEIERAAREAGATAVDIAIDVQVPTREVMGDDPIPGVKNVVLVMSGKGGVGKSTTAVNLTLALKRAGLRVGILDADIYGPSIPTMMGVHGHPPTRDDKKILPLERFGVKMMSIGFLLEDDKQAVIWRGPMLHSALQQFLKDVEWGELDYLVLDLPPGTGDVALTMAQKLKVSGVVMVTTPQEVALQDVYKCVSMCSKLSLPILGVIENMSYFVDSAGVRQELFGRGGGEKIAEFAKAPLLGQIPLEPPVREWGDKGMPIVQSVPDSASAKAFTAVADALIAKVANLHFERTGGTRIPAAKGPTRLRIVR
>NZ_CP011125.1|WP_169791731.1|9975581_9978398_-|penicillin-acylase-family-protein
MTYRFRLLLLSLASLPLLAACGDDDDAPPTTDGGTDAGMMTTTDLALPGLDGEVEVVYDDRGIPHIYGTTRHDVLVVQGYLMSRDRFAQMEFIRRSVLGRIAEIAGEDSLEDDVISRWEGYRRMGVEIYESLPTDDPARLSAEAFVEGINLYIDAVMRREEDPAVMGADVINLVIFGSSFGHWEPADIFALARFQSANLSFDPRDDLNRSARLALIQQAFPADDADPRIAARSGLFEDLFTQRPAREAFTDDGFPDGTTMALLPVIDPRPFGARFTPNVRAIRGAMPFLDRIEERQSRIFGDLVTRGSNNWTVSGEHTASGNPILSNDPHLSLISPAVWWYVHLNTARMGGEDMIDAQGTAFAGLPGVVIGFNRDIAWGVTTTGYDVTDAYQEQITGTCDADGNVTGGTVLWMGGQSPIAFHEETISLASGDPITVRFPYASHRPGSQFLPGSCVAVEGTTDRFVAVSVRYTGWEPSNELATFTGLMTATDVESGRAALDAFEVGSQNFMIVDRDDIMWSTQARIPVRSEMATNLVIDEETGEHTGYCPHMVVPGTGEYEWTGDLADTAIPHELAPARGWIATANQDNVGVTQDGNPCNDEHYVGAGFDYGWREARIQERLAELVERGDITTDDMIALQAETQSPLGRTLRDPIVAILGDTAAIEALGLTEDEETDLAAARTQLMEWTFETPHGVGATDTAEIADSVATTIFNAALTRIIPLALGDETERAMIGGPTSESARLIEWMLTSPSRLLSYDEAAMESVLWDDIRTDAVETKEEIVIRGVLAGLAFLTERMETSDWTEWRWGRLHTVRFNSVVPILGGDDVLSIPAENDPTYPNGFPRHGDWGNVDPGNFGLWNTESFSFGSGASQRLIVEMTADGPRAFNAIPGGQSIDPMSPHKQDEALLWIRNEQPPLYFTEQDVMSHAERELTVRPMD
>NZ_CP011125.1|WP_053238354.1|9993895_9994807_+|hypothetical-protein
MDSCDVQGFRAVRIQRGSTTLVVVPALGAKIASIHAAGREWLWTSATIPYRAPIDGASYVETADSGGFDECFPTVSPCTLPGGVTLPDHGELWAVEPEIDARDSTLSARWTGRRAKYVFERRIDVDPSGAVTMRYAATNSGNVRMPFSWSSHPLMPLTNDVTLVLPKDAITRVDAQHDIDLGGHGAEHRWPVIAGHDMTRPAALGRHYATKLFVALGDVKTVGLAVEGARLTAELEGIPDFGLWINHRGWTPFEGGTPYLNFGFEPCIGAPDSLARALEPGWENAHWLAAGETRRWAMRWTFA
>NZ_CP011125.1|WP_075098174.1|9994877_9996557_+|FAD-dependent-monooxygenase
MDTTDVLVVGAGPTGLTMACELARRGLAVRVIDRAAAPSTRSKAIVVHARTLEIFEDVGIAEDLIARGLVLRGITMWAGGEVIVSAGFEELDTRFSYLLSVSQAETEAVLAAKLESLGVEVERGTTLGSFRQDGTGVTATLRTNDGETTVRAAWLVGCDGAHSTVRETLELPFEGTTYDERFLLADVTIGWDTRDDRISTWFAEDGVIACFPMPGGRWRVIASAPAGDETEAAPTLDEVQAIFDRRTATGGVLGDATWLARFRIHCRQVARYRDDRVFLAGDAAHVHSPVGGQGMNTGIQDAHNLAWKLAMVHRGEARALLLDSYEQERHAIARSVLKSTDLATKVGTLKSSVARALRNEVARHLAGLEVVQQRIAREVSELAVGYQSSPIVREDKISMLQARIGSAAGGETPTLATMREFEHGPRAGSRAPDGRVTVAGSSGTKRLAEILDGRAWTLLLFDGRHESDAGYERYAKLCERIASRWGASVRAFVVTPRASRPAKLPESVPVLLDPDGDLEKRYGATSECAYLIRPDLYVGYRGQPIDETKLDAYLRSILR
>NZ_CP011125.1|WP_053238356.1|9996556_9997363_+|hypothetical-protein
MTRKTLRTTAELIAWMEGEYLSEALLRRATPKPTAKRAPRSVRLVLGLVVPEDPPQLQQYTLEAHGVTRWTLDGEWDVDTPLSFPDVELPDAPVAIVIDAPGRIVLTASHVEVERGATTKYRPPPRPRSDELLVWGPREISWRDVLAAVGAPASTRIVCVRHRGGVLHEQEVEGDALDARFVAPLFDRFELRTASGEPWASIHHMLAIGRTGFYLSITRAPGADDDRWARARRAPIELGECEVMSGSVRTTSSEWARWLQRSAGSSPT
>NZ_CP011125.1|WP_053238357.1|9997332_9999114_-|acyl-CoA-dehydrogenase
MPSANPLISDRFVDFLLYDVLDAPSLAALPAFADHERETFDLWLGACRRLAREVLFPTYRAMDEAPPRLEGGQVRVHPAMRAIWKELAELGVIASTRPASVGGQQLPLTVSTLASAYLMAGNLSAYGYAGLTTGAAHLIEAFGDAWTKQTFMAPLYEGRWTGTMTLTEPQAGSSLADVQTRATRTDQGHFLLRGAKIFISGGDHDVTENVVHLVLARIDGAPPGTKGISLFAVPKRRREGDAWVDNDVSISGVIHKIGWKGLPSVALALGDRNDCHGWLIGTENSGLRCMFQMMNEARLMVGVNATATASVAYHESLAYARERTQGRPLGVVDATTPPVPLVEHADVRRMLLRQKAIVEGALCLLATSAKYADLAEHATDPSLRERSRLLLDLLTPMAKSFPAEYGFESNALAVQIHGGYGYSSEYLPESWLRDQKLNSIHEGTTGIQSLDLLGRKVVAGGGAAIMTWREEILADCARADEAGVDRARTQSVRDALERVVALTGALGARGMKGDVNGMLAHSADYLQLASILAIAWMWTRMSAAIAGRDEAFARGIERAAMYWIATEVPRIEVLARLCESAEPSYVGLDPADL
>NZ_CP011125.1|WP_157070346.1|9999182_10000121_+|UbiA-family-prenyltransferase
MIRALWTLARPKGMVLIAFLPMIGFGFAYWDHGCRIPGFGALAPLGLLATVWAVPHMGTMWLNAALDRDEGQVLFGKSVPVPPGVEKYAYLTLAFSLVAAFVTDVGLGLCVLGCAMLSVLYSHPRTAWKGHAILGPLANAIGYGVLSPLGGFLLSDLPPTPRGAATLALSVTYIVAAYLAAQAFQEDEDRARGYRTLVALRGARFTLDVTRAFLALSVILTLVLAAIGWYPRLVLLAAPAFLAAERYLARWRDVPGGGDGSWAAGFFVRMMIAGLVCIVAVSADYGWSQLRGEPAGGVATASGRPATPACGG
>NZ_CP011125.1|WP_157070459.1|10000966_10001902_+|D-alanine--D-alanine-ligase
MPDDAFEEYDSDATVAAIEEALGANGYRTRRLGSGRSFLARAMQEPGDLVFNIAEGYGTRSREAHVPSALEMLGVPYTHSDPLTLALTLDKAMAKRVVASAGVPTPRFVVVENVEQLHDVPLAFPLIAKPLFEGSSMGVRKHSRVVDLYDLRELCGQLLADYREPVLVEEFCSGPEFTVGILGTGASAQVIGAMEIVPRNCAVEEFVYSLEVKRNYLEEVEYHVPPRRPDELVRAVEDVALAAYRALACRDVGRVDVRLGDDGEPKFLEVNPLPGLNPVTGDLVILARANGLGYADLIGRIVEGARERQGL
>NZ_CP011125.1|WP_053238360.1|10002419_10003457_+|ATP-grasp-domain-containing-protein
MTSLRSIAILWDSLSTTSATSAETGAAEAAAVASIGGVIDEVAHVAASLGLRVERVPLASDARTMLAQVAAIDADVVVNLAESWAGRVRNEAGVAWTLELRGCAYTGATPRALALCLEKPLTRALLASAGVPVPEGATMSDARAPWPLDVRGPWIVKPAAQDASHGVDATSVVHDERAARARVDHLITRGLGPALIERYVDGRELNVSIVELDGAPPRALPIAEIDYSQFPAELPRILTFAAKWDETSDEYRGSASVEARDLDPTRRARVEQVALAAWRALGLRDYGRVDLRLDRDGAPFVIDVNPNPDLSRGAGLCLAAERAGIGYEGLIAGLLRGAARRAHPD
>NZ_CP011125.1|WP_053238361.1|10003440_10003917_+|GNAT-family-N-acetyltransferase
MRIRTELRPTDREAIARIVRAVGVFRPDEVDVAMELVDEGLSTNADQYFFAVAEDDHGAVLGYACWGHAPMTDATYDLYWIAVDPTRHGGGIGQKLLAACEDDVRARGGRLLLIETEGTPDYEPTRRFYLRAGYPEIARVRDYYRVGADKIVYGRSLA
>NZ_CP011125.1|WP_053238362.1|10003913_10004453_+|DUF3109-family-protein
MKKALPVVNGDAARFECVWPGCGGACCKDSRPPVSEGEAARIAEAIPRVVARLRPAARRVVERGAWVTKRMKHGRPMLAIADAYCVFYAEGCALHVLGASEGDKNKYKPATCITFPLDRDDHDRWYVRQHGVENEQWTELACLDPGASSNRAVDSLREEIAFAERVEAGLETWRRPNGR
>NZ_CP011125.1|WP_157070348.1|10004465_10004840_-|hypothetical-protein
MAPRLLWIRDMQGLAALLLATMLVQGPPAALEADRERDRTPRPSFAIELELEVPTLEEVLRETFPVSELLYVRNGWVGISLTEDLAILVDVRTEGIPSSPDPARPMSRGSFSATLGIALSSWDG

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Crispr_ID: NZ_CP011125_40

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_40

9986469-9986577

Orphan

Consensus_repeat	Method
CTGGCGCAGCGCCGTGGTCTTCCTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011125_40

>merge|NZ_CP011125|40|9986469-9986577|CRISPRCasFinder
CTGGCGCAGCGCCGTGGTCTTCCTTCCCCCCTGCCTTCCTCAAAAAAATCCGGAAGGCCCCATCGGGCGCTCCGAGGATCGACCTGGCGCAGCGCCGTGGTCTTCCTTC

>NZ_CP011125|40|33|9986469-9986577|CRISPRCasFinder
CTGGCGCAGCGCCGTGGTCTTCCTTC	CCCCCTGCCTTCCTCAAAAAAATCCGGAAGGCCCCATCGGGCGCTCCGAGGATCGAC
CTGGCGCAGCGCCGTGGTCTTCCTTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053238346.1\|9980017_9980479_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP011125.1\|WP_053238357.1\|9997332_9999114_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173842
NZ_CP011125.1\|WP_053238348.1\|9981450_9981948_-\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NZ_CP011125.1\|WP_075098173.1\|9984854_9985382_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238361.1\|10003440_10003917_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP011125.1\|WP_157070346.1\|9999182_10000121_+\|UbiA-family-prenyltransferase	unknown	unknown	gnl\|CDD\|260125
NZ_CP011125.1\|WP_169791731.1\|9975581_9978398_-\|penicillin-acylase-family-protein	unknown	unknown	gnl\|CDD\|376618
NZ_CP011125.1\|WP_157070344.1\|9985428_9985836_-\|YbjN-domain-containing-protein	unknown	unknown	gnl\|CDD\|341109
NZ_CP011125.1\|WP_075097761.1\|9982184_9983609_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NZ_CP011125.1\|WP_053238347.1\|9980565_9981072_-\|DUF4240-domain-containing-protein	unknown	unknown	gnl\|CDD\|379426
NZ_CP011125.1\|WP_169791732.1\|9986888_9993842_+\|DUF4114-domain-containing-protein	unknown	unknown	gnl\|CDD\|271234
NZ_CP011125.1\|WP_053238349.1\|9984142_9984754_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238354.1\|9993895_9994807_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185695
NZ_CP011125.1\|WP_053239150.1\|9978503_9979613_+\|Mrp/NBP35-family-ATP-binding-protein	unknown	unknown	gnl\|CDD\|378455
NZ_CP011125.1\|WP_075098174.1\|9994877_9996557_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|235728
NZ_CP011125.1\|WP_053238356.1\|9996556_9997363_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070345.1\|9985936_9986164_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238360.1\|10002419_10003457_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|234948
NZ_CP011125.1\|WP_157070459.1\|10000966_10001902_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234948
NZ_CP011125.1\|WP_053238362.1\|10003913_10004453_+\|DUF3109-family-protein	unknown	unknown	gnl\|CDD\|378636

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053238346.1\|9980017_9980479_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.50177e-12
NZ_CP011125.1\|WP_053238357.1\|9997332_9999114_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	3.53404e-125
NZ_CP011125.1\|WP_053238348.1\|9981450_9981948_-\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	9.31312e-08
NZ_CP011125.1\|WP_053238361.1\|10003440_10003917_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.80139e-09
NZ_CP011125.1\|WP_157070346.1\|9999182_10000121_+\|UbiA-family-prenyltransferase	gnl\|CDD\|260125	cd13962, PT_UbiA_UBIAD1, 1,4-Dihydroxy-2-naphthoate octaprenyltransferase. Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.	1.59697e-09
NZ_CP011125.1\|WP_075098174.1\|9994877_9996557_+\|FAD-dependent-monooxygenase	gnl\|CDD\|235728	PRK06184, PRK06184, hypothetical protein; Provisional.	8.52178e-112
NZ_CP011125.1\|WP_157070344.1\|9985428_9985836_-\|YbjN-domain-containing-protein	gnl\|CDD\|341109	cd17026, T3SC_IA_SpcU-like, Class IA type III secretion system chaperone protein, similar to Pseudomonas aeruginosa SpcU. This family includes type III secretion system (T3SS) chaperone proteins similar to Pseudomonas aeruginosa SpcU and similar proteins. In P. aeruginosa, a multidrug resistant pathogen associated with serious illnesses such as ventilator-associated pneumonia and various sepsis syndromes, the T3SS allows injection of effector protein ExoU, one of the most aggressive toxins injected by a T3SS, into the cytosol of target eukaryotic cells, leading to rapid cell necrosis. Chaperone SpcU binds the cytotoxin ExoU, which is a broad-specificity phospholipase A2 (PLA2) and lysophospholipase, and maintains the N-terminus of ExoU in an unfolded state which is required for secretion.	9.43431e-10
NZ_CP011125.1\|WP_075097761.1\|9982184_9983609_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NZ_CP011125.1\|WP_053238347.1\|9980565_9981072_-\|DUF4240-domain-containing-protein	gnl\|CDD\|379426	pfam14024, DUF4240, Protein of unknown function (DUF4240). This presumed domain is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 169 and 263 amino acids in length. This domain is often associated with the WGR domain pfam05406.	2.44651e-39
NZ_CP011125.1\|WP_169791732.1\|9986888_9993842_+\|DUF4114-domain-containing-protein	gnl\|CDD\|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	1.61864e-11
NZ_CP011125.1\|WP_053238354.1\|9993895_9994807_+\|hypothetical-protein	gnl\|CDD\|185695	cd01081, Aldose_epim, aldose 1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism; they catalyze the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate and the histidine as the active site acid to protonate the C-5 ring oxygen.	8.88724e-07
NZ_CP011125.1\|WP_053239150.1\|9978503_9979613_+\|Mrp/NBP35-family-ATP-binding-protein	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	4.09131e-144
NZ_CP011125.1\|WP_169791731.1\|9975581_9978398_-\|penicillin-acylase-family-protein	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	3.99639e-79
NZ_CP011125.1\|WP_053238360.1\|10002419_10003457_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	8.15792e-31
NZ_CP011125.1\|WP_157070459.1\|10000966_10001902_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	5.95371e-67
NZ_CP011125.1\|WP_053238362.1\|10003913_10004453_+\|DUF3109-family-protein	gnl\|CDD\|378636	pfam11307, DUF3109, Protein of unknown function (DUF3109). This bacterial family of proteins has no known function.	1.2081e-08

>NZ_CP011125.1|WP_157070345.1|9985936_9986164_+|hypothetical-protein
MGATRRVKGTIRKLGIEGGVWALVTDEGDTIELIEAPAELCQNGRRAEVELEREGADVTIGMTGAAGRVRSHKML
>NZ_CP011125.1|WP_157070344.1|9985428_9985836_-|YbjN-domain-containing-protein
MRQIHRLTEPRALALQLDELGWSAARHDDRTFRCVHDTSEGELVVFVRLDQNWLIASVVPFLRTRGDNSFELSRWLLRMNRDMYQTKFAYDEDGDVVLTVELPTESLDASEIRTALSDLLQHAIRHRRTLREASA
>NZ_CP011125.1|WP_075098173.1|9984854_9985382_-|hypothetical-protein
MRIEADSVLPFSRERVFRAYRDELPDFTAYLPNVRAIEVKSRTDEGAIATLHNVWHGGGDIPAPIVKVIGGESLSWDDFAKWDQSAWTCEWNIRTSVFTEAVTCSGKNTFIELGADRTRLEIVGDISIDVKKVKGVPSFLAGSIGKTVESFLVKQITANLTSVSDALTKYLQSKG
>NZ_CP011125.1|WP_053238349.1|9984142_9984754_-|hypothetical-protein
MLARQPFVAVTVAEEPRIASAVVSGVRRTLIDLGQWPRVRARAIARMPKVRSWIDSALDGSWCPVAYHIVILESVAAEYGDDGIAAFGRARLLDNMSGGVLSPILRSWMRSYGGAPGHLLRVSPHVWRAVTRDLGRMVVVEMGERATRFRIEEMPEEARRCVAWHRFLEGYGVALLEAGSYPGAHVEISLGETPRQLEGSVRW
>NZ_CP011125.1|WP_075097761.1|9982184_9983609_+|replication-associated-recombination-protein-A
MDLFDHKEDRDREGAPLSDRMRPRRLTDMVGQRHLVAEGSLLRRAIQQDRIPSMILWGPPGTGKTTLARAVAAETKAVFVPFSAVMSGVPELRKILAEAAERKRLHGTRTILFVDEIHRWNKAQQDALLPHVERGAVVLIGATTENPSFAVNAALLSRARVFRLEPHEPSDLRALLERAMSDREHGLGKLALTVDPEALGVIAEMAQGDARRALDVLELAANDATARKVALDREAVEQALASRTLLYDKSGEEHYNVVSAFIKSMRGSDPDAAIYWMMRMLEAGEDPLFVMRRLVIFASEDVGNADPNALQIAVAADAAFRRLGMPEGLHPLAQCCTYLASTVKSNASYEAWQRAQDAVKQHGPLPVPMKLRNAATKHMKAWGYGEGYRYPHAEGGHAQGETYLPDALVGARFYEPKDIGIESRIKQRLAKLRGDERPPTEDPPRAENDARRTDRSRPDVPREEGPRTDPPDER
>NZ_CP011125.1|WP_053238348.1|9981450_9981948_-|PilZ-domain-containing-protein
MTTRNVLEMIFEYQLLRAKQDRLEVPLDDDERARLFGLGRLLTGDGSPGARTMPRLPFPKTVSFTMPGCFESGEVKNLSGNGLAIATTRPPVIGARVIVRLVDEAAGCEYFFPCRVIWARRTNLPGMGLVFDGVPTRSEYLAEESTGVWRRAMRMGDPPREANVA
>NZ_CP011125.1|WP_053238347.1|9980565_9981072_-|DUF4240-domain-containing-protein
MDEAWFWALIDASRRGCDHRSADEARGQPAVLERLLRALTPEDVAGFAHIFETLHARAYRWDLWHAAYVIEGGCSDDGFTDFRSGLIGLGREVFENALRDPLTLARLSGDSAFSQEGMRYAARRAYERITGRRLAVDVARAIEPAGEQLDEEVFLRKYAELERRFGPR
>NZ_CP011125.1|WP_053238346.1|9980017_9980479_+|RDD-family-protein
MAAEVSMDSLVPAELPVRIAARAIDVAIVVAMNVGLGQLMGFGFDWLIVGSMLVLAYFALLDAFVGATFGKLALGLRVIGPEGERVTMKQALTREAFTVLGAIPFIGPILALAAWIWIVVTIRNSPLRQGRHDALAGGTRVVRATKTVALRKP
>NZ_CP011125.1|WP_053239150.1|9978503_9979613_+|Mrp/NBP35-family-ATP-binding-protein
MAELTTESLRTALSKVVDPVFEKPMLDIGALTDLSVEPGGEVKVRAHLATPSSTVHAKVREEIERAAREAGATAVDIAIDVQVPTREVMGDDPIPGVKNVVLVMSGKGGVGKSTTAVNLTLALKRAGLRVGILDADIYGPSIPTMMGVHGHPPTRDDKKILPLERFGVKMMSIGFLLEDDKQAVIWRGPMLHSALQQFLKDVEWGELDYLVLDLPPGTGDVALTMAQKLKVSGVVMVTTPQEVALQDVYKCVSMCSKLSLPILGVIENMSYFVDSAGVRQELFGRGGGEKIAEFAKAPLLGQIPLEPPVREWGDKGMPIVQSVPDSASAKAFTAVADALIAKVANLHFERTGGTRIPAAKGPTRLRIVR
>NZ_CP011125.1|WP_169791731.1|9975581_9978398_-|penicillin-acylase-family-protein
MTYRFRLLLLSLASLPLLAACGDDDDAPPTTDGGTDAGMMTTTDLALPGLDGEVEVVYDDRGIPHIYGTTRHDVLVVQGYLMSRDRFAQMEFIRRSVLGRIAEIAGEDSLEDDVISRWEGYRRMGVEIYESLPTDDPARLSAEAFVEGINLYIDAVMRREEDPAVMGADVINLVIFGSSFGHWEPADIFALARFQSANLSFDPRDDLNRSARLALIQQAFPADDADPRIAARSGLFEDLFTQRPAREAFTDDGFPDGTTMALLPVIDPRPFGARFTPNVRAIRGAMPFLDRIEERQSRIFGDLVTRGSNNWTVSGEHTASGNPILSNDPHLSLISPAVWWYVHLNTARMGGEDMIDAQGTAFAGLPGVVIGFNRDIAWGVTTTGYDVTDAYQEQITGTCDADGNVTGGTVLWMGGQSPIAFHEETISLASGDPITVRFPYASHRPGSQFLPGSCVAVEGTTDRFVAVSVRYTGWEPSNELATFTGLMTATDVESGRAALDAFEVGSQNFMIVDRDDIMWSTQARIPVRSEMATNLVIDEETGEHTGYCPHMVVPGTGEYEWTGDLADTAIPHELAPARGWIATANQDNVGVTQDGNPCNDEHYVGAGFDYGWREARIQERLAELVERGDITTDDMIALQAETQSPLGRTLRDPIVAILGDTAAIEALGLTEDEETDLAAARTQLMEWTFETPHGVGATDTAEIADSVATTIFNAALTRIIPLALGDETERAMIGGPTSESARLIEWMLTSPSRLLSYDEAAMESVLWDDIRTDAVETKEEIVIRGVLAGLAFLTERMETSDWTEWRWGRLHTVRFNSVVPILGGDDVLSIPAENDPTYPNGFPRHGDWGNVDPGNFGLWNTESFSFGSGASQRLIVEMTADGPRAFNAIPGGQSIDPMSPHKQDEALLWIRNEQPPLYFTEQDVMSHAERELTVRPMD
>NZ_CP011125.1|WP_169791732.1|9986888_9993842_+|DUF4114-domain-containing-protein
MQVDGTIVPVGNALQDALNTYEGVAPPAANAIHAVIDAAQLPEIFLPSTSNAVVFVDIAEGAGFENSFGYYNVGDDPRVTTNLRPIMGCGVQASNHANEVPNYVRSAEAGTSVSVDFNAERTAGRYRGGYIAFYLITPEDPANPGSQGSPNCGDFGSGSQSFYGRAYYTQRDFNNDGDFVHHLVYQSRVTANRFYFGFEDLFRGGDNDYEDMAMQVTGLTPPCSPGVEICNGRDDDCDGLVDAADSSLSDDDVACTCDNVSMTCEGGAQRGVCRTGATACVAGALICRSTVGPSAEQCNNLDDNCDGTVDNGAAGTGVACDGTDADLCNEGVFACTSGALTCTDATGANAETCNGADDDCDTRTDENVPGVGAACDGADGDLCNEGVTTCAGASGLRCSDATGTNAELCNGADDDCDGAVDDGPTDVGVACSTGVGLCRSNGATICSMGAPVCNATPIPPRAERCNALDDDCDGATDETFRLGEACVAPGVCGPGVLECAGDTGTRCSSAPGGSGDGSRAETCNGLDDDCDTRVDEGLTDLGSCGESTGECEPGRLRCLAAAPTCVGGIGPTPEICDGRDNDCNGDNDDMPTDVGASCGDDTGECTAGTQACVGGMLRCQGAVGPGTERCNSLDDDCDAITDEDPSDVGATCGTTDVGVCDLGSTICVAGGLVCAGATEPNVEVCNGDDDDCDGDTDEDAIDVGRVCGSAMGTCTPGITVCVAGAPICQGATTGTPEICNGIDDDCDTVIDDSPSDEGGVCGMGEGVCEEGELRCIAGSLQCVGGVLPGTEVCNGLDDDCNGSIDEGDLCEGGVCVGGRCSVPCQMTEFGERCPSGEICVEHYCVPDECEGVTCEPGPDGTKNVCVEGGCVPACDTVTCDAPNVCRRTDGACVGNNCIFLPYLCTDAQICAAGECVDDPCAGVSCDAGQFCRGGACVGSCAGVRCGVGEVCRGGECESTGCNTPCGAGQVCAGGACVDDPCGSLGCDTGEVCDPTRGECVDDPCRNVTCPGEGEICRLGECYAPSDFEVDAGTGGMDAGTGSGPREVLAAGGGGMCSASGAGTGGASGALAWIALGIVGIVIARRRRSSANAGTASANAGTASANAGTGIALVVALVLGGCEVDPYCVANCDGGAELDAGPGDDAGTDGGTDGGRGRPDGCVVGATEECNESDDDCDGLVDEGIDLTSDSRHCGDCSTTCERTGAQTQCTEGACELLECFDGFVDLNGDIDGPFADTDGCEYRCFSSNGGVEACDTIDNDCDGDVDETFDFQGDEANCGRCGQVCTFFRVTTATCDMGTCEFDPATDCETGYIDQNAVQFDGCEFECTPTGAEVCDGLDNDCDTRTDEGFGLETDPNNCGRCGRVCTFPNATPRCNTGVCGFDPMTDCNAGFSDRDGVQLNGCEYPCTPTNGGVEICDGLDNDCNGRVDGPTTDSGASCNRAPGGTATGVCTSTGTLTCVGATLRCVGAPEPTREICDGLDNDCDGSSDDSPVDVGRVCAPAVGACTAGFSTCGGGTLGCVRAVGPTPEICNGLDDDCDGTIDDMPTDPTLGDACGTDTGECVRGAIACTDGRLVCAGSVGATLETCNNRDDDCDGMTDDDPVDVGGSCGSSVGACVPGSLVCSSGSLVCSGGASASSEICDNQDDDCDGTVDEMLSQSCYTGPAGTSGVGLCRGGTRVCAAGTFGTCAGQVVPAGETCTNTDEDCDGRIDEGVTRACYTGPAGTNGVGLCRGGTQACTAGAFGGACTGQVTPATSESCDSLDDDCDGRTDEGAGGGALTRSCYTGAAGTAGVGTCRAGTQTCRFGAFEAACAGQIVNTLDRCGDTLDTDCDGLNDTAEGCLTAGGELRIDTGGGDDPGEFHSFEVQLASGGDPVGRNVYAVWVDKRNGGSTADVFFSRSTNGGSTFSAPVDLTDFATTRAVAPRIAVGRVGSNDVVYVTFQIVVDGVRNVYVRTSADGGASFGSAVALSTLAARDNFKQSVATSGARAVVAWERLNTSTLDRTVVYAATTNSGANWTDVATVSVNSGATPNAGEPVAAVTSTGRFVFAWRELRVSASPSRTTFDVYATWTDDITMPIPAANERRLDGDTTNARASDDLRIVSDGERVYVAWTDVATAAGGGSDVVFSRSINNGASWSPERILDDPSGEVSSSTQATLAIDPATSSTTDDRLFVAWVDTRDGTQIFLARSTDSGATWSTPVRASQATGGVAVPGVNDSPAIVYAGGDRVIVAYVNDANGASTYRRVRAAVSIDAGASWQVADPVVDSNGGAGGGEADYPSIARADSTTPFVGAVIGWIDFRSGTRVNGDVYRARVGR
>NZ_CP011125.1|WP_053238354.1|9993895_9994807_+|hypothetical-protein
MDSCDVQGFRAVRIQRGSTTLVVVPALGAKIASIHAAGREWLWTSATIPYRAPIDGASYVETADSGGFDECFPTVSPCTLPGGVTLPDHGELWAVEPEIDARDSTLSARWTGRRAKYVFERRIDVDPSGAVTMRYAATNSGNVRMPFSWSSHPLMPLTNDVTLVLPKDAITRVDAQHDIDLGGHGAEHRWPVIAGHDMTRPAALGRHYATKLFVALGDVKTVGLAVEGARLTAELEGIPDFGLWINHRGWTPFEGGTPYLNFGFEPCIGAPDSLARALEPGWENAHWLAAGETRRWAMRWTFA
>NZ_CP011125.1|WP_075098174.1|9994877_9996557_+|FAD-dependent-monooxygenase
MDTTDVLVVGAGPTGLTMACELARRGLAVRVIDRAAAPSTRSKAIVVHARTLEIFEDVGIAEDLIARGLVLRGITMWAGGEVIVSAGFEELDTRFSYLLSVSQAETEAVLAAKLESLGVEVERGTTLGSFRQDGTGVTATLRTNDGETTVRAAWLVGCDGAHSTVRETLELPFEGTTYDERFLLADVTIGWDTRDDRISTWFAEDGVIACFPMPGGRWRVIASAPAGDETEAAPTLDEVQAIFDRRTATGGVLGDATWLARFRIHCRQVARYRDDRVFLAGDAAHVHSPVGGQGMNTGIQDAHNLAWKLAMVHRGEARALLLDSYEQERHAIARSVLKSTDLATKVGTLKSSVARALRNEVARHLAGLEVVQQRIAREVSELAVGYQSSPIVREDKISMLQARIGSAAGGETPTLATMREFEHGPRAGSRAPDGRVTVAGSSGTKRLAEILDGRAWTLLLFDGRHESDAGYERYAKLCERIASRWGASVRAFVVTPRASRPAKLPESVPVLLDPDGDLEKRYGATSECAYLIRPDLYVGYRGQPIDETKLDAYLRSILR
>NZ_CP011125.1|WP_053238356.1|9996556_9997363_+|hypothetical-protein
MTRKTLRTTAELIAWMEGEYLSEALLRRATPKPTAKRAPRSVRLVLGLVVPEDPPQLQQYTLEAHGVTRWTLDGEWDVDTPLSFPDVELPDAPVAIVIDAPGRIVLTASHVEVERGATTKYRPPPRPRSDELLVWGPREISWRDVLAAVGAPASTRIVCVRHRGGVLHEQEVEGDALDARFVAPLFDRFELRTASGEPWASIHHMLAIGRTGFYLSITRAPGADDDRWARARRAPIELGECEVMSGSVRTTSSEWARWLQRSAGSSPT
>NZ_CP011125.1|WP_053238357.1|9997332_9999114_-|acyl-CoA-dehydrogenase
MPSANPLISDRFVDFLLYDVLDAPSLAALPAFADHERETFDLWLGACRRLAREVLFPTYRAMDEAPPRLEGGQVRVHPAMRAIWKELAELGVIASTRPASVGGQQLPLTVSTLASAYLMAGNLSAYGYAGLTTGAAHLIEAFGDAWTKQTFMAPLYEGRWTGTMTLTEPQAGSSLADVQTRATRTDQGHFLLRGAKIFISGGDHDVTENVVHLVLARIDGAPPGTKGISLFAVPKRRREGDAWVDNDVSISGVIHKIGWKGLPSVALALGDRNDCHGWLIGTENSGLRCMFQMMNEARLMVGVNATATASVAYHESLAYARERTQGRPLGVVDATTPPVPLVEHADVRRMLLRQKAIVEGALCLLATSAKYADLAEHATDPSLRERSRLLLDLLTPMAKSFPAEYGFESNALAVQIHGGYGYSSEYLPESWLRDQKLNSIHEGTTGIQSLDLLGRKVVAGGGAAIMTWREEILADCARADEAGVDRARTQSVRDALERVVALTGALGARGMKGDVNGMLAHSADYLQLASILAIAWMWTRMSAAIAGRDEAFARGIERAAMYWIATEVPRIEVLARLCESAEPSYVGLDPADL
>NZ_CP011125.1|WP_157070346.1|9999182_10000121_+|UbiA-family-prenyltransferase
MIRALWTLARPKGMVLIAFLPMIGFGFAYWDHGCRIPGFGALAPLGLLATVWAVPHMGTMWLNAALDRDEGQVLFGKSVPVPPGVEKYAYLTLAFSLVAAFVTDVGLGLCVLGCAMLSVLYSHPRTAWKGHAILGPLANAIGYGVLSPLGGFLLSDLPPTPRGAATLALSVTYIVAAYLAAQAFQEDEDRARGYRTLVALRGARFTLDVTRAFLALSVILTLVLAAIGWYPRLVLLAAPAFLAAERYLARWRDVPGGGDGSWAAGFFVRMMIAGLVCIVAVSADYGWSQLRGEPAGGVATASGRPATPACGG
>NZ_CP011125.1|WP_157070459.1|10000966_10001902_+|D-alanine--D-alanine-ligase
MPDDAFEEYDSDATVAAIEEALGANGYRTRRLGSGRSFLARAMQEPGDLVFNIAEGYGTRSREAHVPSALEMLGVPYTHSDPLTLALTLDKAMAKRVVASAGVPTPRFVVVENVEQLHDVPLAFPLIAKPLFEGSSMGVRKHSRVVDLYDLRELCGQLLADYREPVLVEEFCSGPEFTVGILGTGASAQVIGAMEIVPRNCAVEEFVYSLEVKRNYLEEVEYHVPPRRPDELVRAVEDVALAAYRALACRDVGRVDVRLGDDGEPKFLEVNPLPGLNPVTGDLVILARANGLGYADLIGRIVEGARERQGL
>NZ_CP011125.1|WP_053238360.1|10002419_10003457_+|ATP-grasp-domain-containing-protein
MTSLRSIAILWDSLSTTSATSAETGAAEAAAVASIGGVIDEVAHVAASLGLRVERVPLASDARTMLAQVAAIDADVVVNLAESWAGRVRNEAGVAWTLELRGCAYTGATPRALALCLEKPLTRALLASAGVPVPEGATMSDARAPWPLDVRGPWIVKPAAQDASHGVDATSVVHDERAARARVDHLITRGLGPALIERYVDGRELNVSIVELDGAPPRALPIAEIDYSQFPAELPRILTFAAKWDETSDEYRGSASVEARDLDPTRRARVEQVALAAWRALGLRDYGRVDLRLDRDGAPFVIDVNPNPDLSRGAGLCLAAERAGIGYEGLIAGLLRGAARRAHPD
>NZ_CP011125.1|WP_053238361.1|10003440_10003917_+|GNAT-family-N-acetyltransferase
MRIRTELRPTDREAIARIVRAVGVFRPDEVDVAMELVDEGLSTNADQYFFAVAEDDHGAVLGYACWGHAPMTDATYDLYWIAVDPTRHGGGIGQKLLAACEDDVRARGGRLLLIETEGTPDYEPTRRFYLRAGYPEIARVRDYYRVGADKIVYGRSLA
>NZ_CP011125.1|WP_053238362.1|10003913_10004453_+|DUF3109-family-protein
MKKALPVVNGDAARFECVWPGCGGACCKDSRPPVSEGEAARIAEAIPRVVARLRPAARRVVERGAWVTKRMKHGRPMLAIADAYCVFYAEGCALHVLGASEGDKNKYKPATCITFPLDRDDHDRWYVRQHGVENEQWTELACLDPGASSNRAVDSLREEIAFAERVEAGLETWRRPNGR

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Crispr_ID: NZ_CP011125_43

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011125_43

10251696-10251983

Orphan

Consensus_repeat	Method
GAGCTCGAGCAGCGCGCGCGCGACGCCGAG	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP011125_43

>merge|NZ_CP011125|43|10251696-10251983|CRISPRCasFinder
GAGCTCGAGTCGCGGGCGCGCGATGCCGAGGCCCAGCTCGCGCCGCTGCGCAGCCGCCTCTCGGAGCTCGAGCAGCGCGCGCGCGACGCCGAGGCGAAGTCGGAGCCGCTGCGCGGTCGGGTGAGCGAGCTCGAGCAGCGCGCGCGCGACGCCGAGTCGCAGGCCACGCCGCTCCGCACCCGTGCCGGCGAGCTCGAGCAGCGCGTGCGCGATCTCGAGACCACGATCGCAGCGCAGCGCCGCGAGGTCGACGAAGCGGAGCGCGCGCGCCGCGCCGGCGAGGAAGAG

>NZ_CP011125|43|36|10251696-10251983|CRISPRCasFinder
GAGCTCGAGTCGCGGGCGCGCGATGCCGAG	GCCCAGCTCGCGCCGCTGCGCAGCCGCCTCTCG
GAGCTCGAGCAGCGCGCGCGCGACGCCGAG	GCGAAGTCGGAGCCGCTGCGCGGTCGGGTGAGC
GAGCTCGAGCAGCGCGCGCGCGACGCCGAG	TCGCAGGCCACGCCGCTCCGCACCCGTGCCGGC
GAGCTCGAGCAGCGCGTGCGCGATCTCGAG	ACCACGATCGCAGCGCAGCGCCGCGAGGTCGACGAAGCG
GAGCGCGCGCGCCGCGCCGGCGAGGAAGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011125.1\|WP_053238562.1\|10242308_10243313_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|163279
NZ_CP011125.1\|WP_053238566.1\|10248577_10249042_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238576.1\|10258910_10259240_-\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|238308
NZ_CP011125.1\|WP_157070394.1\|10253370_10253880_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_169791746.1\|10253876_10254446_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP011125.1\|WP_053238574.1\|10256636_10258187_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|338048
NZ_CP011125.1\|WP_053238573.1\|10255866_10256472_+\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|379311
NZ_CP011125.1\|WP_157070392.1\|10243547_10244183_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070390.1\|10238813_10239455_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238578.1\|10260047_10260554_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238565.1\|10247346_10248489_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP011125.1\|WP_053238561.1\|10241739_10242309_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238564.1\|10244205_10247337_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|169983
NZ_CP011125.1\|WP_053238577.1\|10259301_10260003_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_053238572.1\|10255194_10255818_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011125.1\|WP_157070393.1\|10249042_10251070_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NZ_CP011125.1\|WP_053238575.1\|10258399_10258735_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237177
NZ_CP011125.1\|WP_053238560.1\|10241027_10241675_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP011125.1\|WP_157070391.1\|10239494_10240964_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NZ_CP011125.1\|WP_157070395.1\|10254519_10255161_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011125.1\|WP_053238562.1\|10242308_10243313_+\|SDR-family-oxidoreductase	gnl\|CDD\|163279	TIGR03466, HpnA, hopanoid-associated sugar epimerase. The sequences in this family are members of the pfam01370 superfamily of NAD-dependent epimerases and dehydratases typically acting on nucleotide-sugar substrates. The genes of the family modeled here are generally in the same locus with genes involved in the biosynthesis and elaboration of hopene, the cyclization product of the polyisoprenoid squalene. This gene and its association with hopene biosynthesis in Zymomonas mobilis has been noted in the literature where the gene symbol hpnA was assigned. Hopanoids are known to be components of the plasma membrane and to have polar sugar head groups in Z. mobilis and other species.	1.31659e-106
NZ_CP011125.1\|WP_053238565.1\|10247346_10248489_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	2.26024e-62
NZ_CP011125.1\|WP_053238575.1\|10258399_10258735_+\|hypothetical-protein	gnl\|CDD\|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	0.000118306
NZ_CP011125.1\|WP_053238564.1\|10244205_10247337_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|169983	PRK09579, PRK09579, multidrug efflux RND transporter permease subunit.	0
NZ_CP011125.1\|WP_169791746.1\|10253876_10254446_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.18659e-12
NZ_CP011125.1\|WP_157070393.1\|10249042_10251070_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	5.89453e-60
NZ_CP011125.1\|WP_053238576.1\|10258910_10259240_-\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|238308	cd00552, RaiA, RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site. RaiA is also thought to counteract miscoding at the A site thus reducing translation errors. The RaiA fold structurally resembles the double-stranded RNA-binding domain (dsRBD).	3.30453e-18
NZ_CP011125.1\|WP_053238560.1\|10241027_10241675_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.28577e-11
NZ_CP011125.1\|WP_053238574.1\|10256636_10258187_+\|hypothetical-protein	gnl\|CDD\|338048	pfam11617, Cu-binding_MopE, Putative metal-binding motif. The seqeunce of structure 2vov is not matched in any other sequence either in UniProt or in NCBI (Sep2014). The model is of a short repeat not found on the G1UBC6 - 2vov - protein. The presence of conserved cysteine residues and the lack of hydrophobic residues suggests that this repeat might be a metal-binding site, perhaps for zinc or calcium ions.	7.23957e-06
NZ_CP011125.1\|WP_157070391.1\|10239494_10240964_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	2.24604e-08
NZ_CP011125.1\|WP_053238573.1\|10255866_10256472_+\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	1.77445e-05

>NZ_CP011125.1|WP_157070393.1|10249042_10251070_-|N-acetylmuramoyl-L-alanine-amidase
MRALLALASLLAIAAPAAAQPLVVIDPGHGGSDPGAVGCSIEEEDVVLDVSQRLQVLLERDGVRIAMTRDADTTVGLSARATFANSRGATGFVSIHSNSNGGTPATGTETFVYPGSNARTRALGQGVQSAMIAAWGLRDRGLKEGNFAVVRETTMPAALGELAFTNNCATDARYLSDPAQRQRMAEHLRTAILNWLGVSPMPTTGTLRGVVFEDQGVGTEDITVRIGGAGVRVTETGASATSAADGAWSFTVPPGEYTVEASHAGHVTASRRCAVVSGMTTWCSVGLLPESTPPPPDAGSVGEEDAGVIEEVDAGARDAATGGDAGPARDAGATGPGREMIDGGCSVGHGSGSSAWLAMVLAGLVIAMRRRRAPVALLATFAIVGCAREAAPTAHESDLRGIVDEENVAPSARIGARPVASFVTLGPRREWLVQDLVTPVLSPDGTRALLASPDHTALFVLELDGTSTVRELCGVGRCGWEPQWQDDGAAVAFRTEGQSGTAVPAEAVSLEDGRSLAVHVGERGVHAWTDEDDRAWLRIDGRVREIGPEGERVMMPTLTSDRRHVVMWGLTEGVLIHRVRDGAIVYAGPGGHPRVDPSGRWLVLERTEDDGHEITRSDLYVVDLADPSYAIAPLVLSDDRVERMPSLSRIGDDGAGTLAYVEEGALVVREVRLSR
>NZ_CP011125.1|WP_053238566.1|10248577_10249042_+|hypothetical-protein
MESTVYGQDEHLLYARIGPVVVAQVLPDHTDASFEIYLSALERELGARREDERVAVLFYVPGGGTWDAGRRKRVNDVLARYVVKRRRTTSVWVLCTPSAATRGVATALFWVVPPPYEYRIRADLGAGLEDVREKHPDFSPSAFSSELARITRRR
>NZ_CP011125.1|WP_053238565.1|10247346_10248489_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MRRGVAALVVLLVILALGGIAGIKWSQITTIIAHAQDMERQGPPPEAIGAAVAEEQVWPQTAHAVGTVASNRDVAIANELPGVVARIAFDSGDAVRAGDLLVQLDVSVERANLDAAIANERLARVTADRAHQLVARGVASEQEGDNAEANAASAAAQVESLRATIERKTVRAPFDGRVGIRAVRLGQYLQPGTTVTTIAGEDATYVDFTLPQELLPALQVGMRAEVRGAGERETLAGEVAAIEPSVDPTTRTVGLRAIVRTGQEQLRAGMFVDVDVVLPQRESVVAVPSTAIVHAPYGDSVYLLEPSDRRTPDGQPILVARQTFVRLGEQRGDFVAITQGVEPGRQVVSAGAFKLRNNAPVIITEDAAPQPELAPRPVSR
>NZ_CP011125.1|WP_053238564.1|10244205_10247337_-|efflux-RND-transporter-permease-subunit
MKGLTDVFVRRPVLAIVVNLLILVAGVQAIRSLSVRQYPRLELATVTISTVYVGASADLVRGFITTPIERAISAADGIEYIESESTQGISTIRARLRLNFPASDALADISARVNQVRNELPPEAELPTILIEPSDAQIAAMYLSFRSPILEPNQVTDYLVREVQPRLSAIDGVQRADLLGGRAFALRAWLDPQRMASLGVSPSDVSRALADENYLAAVGNTDGALVRVDLTATTDLQSVDQFRRLVVRRDGDTLIRLADVADVQLGSESYDQDVRFAGERAVFMGVWVRPNANALEVIERVRAELALLQADLPVGMEATVAYDSTEYIEDAIREVTRTLLETVLIVVLVITAFLGSLRGSIVPVVAIPLSLIGAVFLMQVLGFTLNLLTLLAIVLSVGLVVDDAIVVVENVERHIREGQTRVQAALLGARELVGPIIAMTITLLAVYVPVGFQGGMTGELFREFAFTLAGAVLISGIVALTLSPVMSSRLVPEKQGRIARAVARAFSAVQRGYGHALDTTLAMRPVVYVVWILIALATIPMFMLSSSELAPEEDQGVVFSSLEVPANASLEQVSAYAGELQHVFEQDPDYHQSFQLTTPGTAFGGMIAAPWQERERDIFAIQGALTPRVSAIAGVRAPLFLPAALPSPGTLPIEFVVSASADHEEIVRYTERLTEIAAQSGEFAFPPISDVRFDEARADIVLDRDQIAAMGVNMGQIGSDLSWMLSGNYVNRFNMAGRSYRVIPQIVRTSRLVPRQLQDIHVTGPNGTLIPLGAIATLQETVEPRTLNRFQQLNSVKLSGVPARSVDAALRVLEEAAAETLPPGYRVDYTGESRQLRQEAGKFLPVLGLALLVIFLVLAAQFDSFRDPFVILAGSVPLALFGALVFTFLHFEGPPGVEFGLTSGWTTTLNIYSQVGLVTLVGLIAKHGILIVEFANDAQREGLSKIEAVKHAAATRLRPILMTTAATIAGHFPLTLVTGPGAEARNSIGLVLVGGMAIGTIFTLFVVPAVYVLIAREHRVRVEEKRREEEPEMGGALLPSPAE
>NZ_CP011125.1|WP_157070392.1|10243547_10244183_+|hypothetical-protein
MSEPMSGGVEGVLYDSQRVSSERLESAVTELASVYAVRWRWAADLFDAAISATRFDIRVHTAEMALLQRTFFHYLTTARPDPSDRIRIGRAVLSLIGSSERHAIERAAAVTNKIMRNPENVGVDFAPEELTALIASEPPALEARSVVASALSRAVEHRMDDASSRAVVETALGEGRKLVLSFEAQIHAALAWLSLSSAEEIHVVTNDEQSG
>NZ_CP011125.1|WP_053238562.1|10242308_10243313_+|SDR-family-oxidoreductase
MRALVTGAAGLIGHHVVRQLCERGDDVRALVLARDDLRNLRGLDVEVRIGDVTDRDSVARAMREVEVVFHLAAIYALWTPDRGARMRRVNVEGTRIVLDEARRAGVRRVVHTSSIARFGGQGPGRRATESSPFALGVTKSAYAISKRDAHEVALDAARDQDVVIVAPCGPIGPGDVGPTPTGRLLVECLRLPVIAVTPTVTNFVDVRDVARGHLLAAERGARSESYLLGHRDLSLAQLAGMALEVTGRRAPIVEIPWRAARIAGRAMSALADRVTHRAPPITTEAIAIAELGLAADASRAVRELGLPQTPIERALSDALKWFDREGYLAARLAA
>NZ_CP011125.1|WP_053238561.1|10241739_10242309_+|hypothetical-protein
METIAARSLDVHSPARSTGAAPSSIRRLDELLHLDHDALAALYERATLPQLEAISGDLRGRMLAVPAVPSWLSKLPVAWARTGSFPWRGKSFAPHGEGRGEGNNRVVFDAIRLFRFETFAGPSRHDGQPAIQLDYDHAENPFFIRKIEDEIRELAPGVYLGQAWLRVGAEPRFVLWFGLEDRRRVEGTR
>NZ_CP011125.1|WP_053238560.1|10241027_10241675_-|TetR/AcrR-family-transcriptional-regulator
MSSGRAKKKPTKSEPRSRAESSAETREALIRAGIELFASEGLDAPSLDAICARAGKTRGAFYVHFPDRDAFLAAVMERVGLPFLDVVLGSDDTPPTLTTVVQRFLVAVASGEYPLTAKDGVRPHQLLDACARSEPVRARYVALIESSIARLAAIVARGQDEKTLRDDVRPEDAAAILLAAVVGAQTLMELRASVDLGPAAAAMLAMLRRHPGPQE
>NZ_CP011125.1|WP_157070391.1|10239494_10240964_-|tetratricopeptide-repeat-protein
MRAATIAAVTIRSWALVAMVLSLAPPLAATAPVASAQRRERAPIPAMVRGLRNAAGYAGVERDRIAAELSAAMRAIDATSASDGCKAIARRRVEAIAAAVTESPDRAASRAWEAARRAVASAGECRASDEAPSEALIALEVAVWLGVVSNGASAEVMVQDPGPRALFVRGAALLASSQWELARARFEAGRAVVGDADPVLSADLVRGVGEAHLGAMRDAEGVRAIEDAASRATSAADAGWRALVDAQVALGIAHAHARRFADALAAYDRALSVAQSRLGAGDPWVADLVGRRAVALGELERVDDAIIANQSALAIRERALGPGHPDALVSRSNIAMMLQRRGDLAGALAMHQQILDTRTRVLGASDPSVAVTLDAIAFIERTAGRHAEAEALLRRAISIRERSLPPGHPDRGRSHRALAPVLVALGRMDEAVQLAERGVLLTIEAVGPDHPDVATAWSTMLQVAQAVGRDELAQRAQREIARVRAISRR
>NZ_CP011125.1|WP_157070390.1|10238813_10239455_-|hypothetical-protein
MDPDTLFLAAGSVIAGAVLGAPLGPSGAVVASMMLSGRRDDAYVASAGVPIGHAVVAAIATSATLLASSALGAHERTLRIVAALLLVAIGVRLALAKPRVAASRASAGSIAGTFLLTVLNPTLLAAYALVTAGPLAIGPLAPGPDASLAAALVIVVPSATIGAALAFVGATALLDRLQRAMSDARRATVARGLAAALVVLGAVGLARSLFGGA
>NZ_CP011125.1|WP_157070394.1|10253370_10253880_+|hypothetical-protein
MHEATPDQVAQRVRELGAGRVFGTASSARARVVHDPAEAWSYAFSREDLEDGEDWVQLRGHALAERWSLCAADLGRELVTSHDLIAPLSSREVDTIARQIASRLALGREYPEEIFTDLKLILATSKAPRPSAFSPMIDGMFAAYQRGAYPCGWAGRWPEGEIVWFVPPA
>NZ_CP011125.1|WP_169791746.1|10253876_10254446_+|GNAT-family-N-acetyltransferase
MSLVHPARSTCHFLDRAPSTTRCAMSIAIRRLGAHDAPAYRALRALGLRQAPDAFRVAPEDEQHETDASVAQRLAGHAVFGGERDATLLGVAGVTGFDGAKLRHRALLWGMYVHPDARGTGLADALVARAIEHASLDHQRLILTLAADNVRALRLYERHGFVVYGREPDAIRRSPDAYVDELLMSRALR
>NZ_CP011125.1|WP_157070395.1|10254519_10255161_+|hypothetical-protein
MIGAVLTAWWAWRARDRWGRVSRPAALVGVGPYRRALVRSHEPRRVPLAVLVVAGVGCVWGLLTTLVFAPSGLVFLLAPARHDPVRQILLTLSGLGVFATAIAAFALGPSLMRASRALIERDHDAGERALSVATWSSLHHAMVLVSFVLFAVHEDDARIAVVVAVPCAIGLVHAWSLGRACAIVARVQRDERDDEDASSESAASIVIGDRSTL
>NZ_CP011125.1|WP_053238572.1|10255194_10255818_+|hypothetical-protein
MGLVLYALFVLGIAMVAVVATAYWSVRFAARWGSVPGPALRVGRGAYRESRVSREVPRGTPSPITWTAGIGMVWSVLTSLVFAPMMLCVGAMTDGVGLIGVVTGVGLVVTGSSGFFLGLALACIAYFVLRRDREVVDLAEGAVVWSVLHHLSGLLFVVLHAIVTPGPGLLILTAPIWVFGLAHAYALQDAAQLTLEGPPPDDEIIAA
>NZ_CP011125.1|WP_053238573.1|10255866_10256472_+|HEAT-repeat-domain-containing-protein
MKSGDILTAPILRLVPGEKEDADEMMGFANEEYWLLARVIEADGDAPAEDIYTTEDGRTRIHWIQDPKISRGYIALAGENVEEVAELIRSGMSILGLEEIRQRALSATSRADRMRSIYDLALAAPIEHDPGIFEIFGSYLEDADPDVRGAAVLAISYVGWREFLEPLRTRASEDADGSVREDATILIGNLQKYPARSVVAR
>NZ_CP011125.1|WP_053238574.1|10256636_10258187_+|hypothetical-protein
MMRRAAFVCLTALSLLLPACMQNEPAPPMGMLMDEPGEVGVVSADLTAAERRVRAGQIRDAAFGAGMEQGWLLAGIADAETRMSHCWRELTWACQGPNSSDCGGGPVVAGAGDGPCADRQGGLGMFQFDAGTFEQTLAREGNRILSIAGNTQAAVDFVANMVVRSAYVPGVENRAQAIAWMNGVRIGNDRWDAWIRTVTHYYNGCAPSYSCFSQRYAHYRDNTTGVYNEMGPDFWVTTRDWGAAYVSQSFPLARDPFPLEAGATHEGYLEMRNTGAQTWRPGEVFLGTTEPRDVASPIAADTWPAPNRAATIDREVPPGGTGRFVFRVRAPDAPGDYPQFFNLVREGVAWFSESGGPVDAQIQIRVTSTAPPPCPGGIGDAWSCEGDDRVRCERGMVFREPCELGCNAGTCNAPATDEDGDGYGSDDCAPGDADVHPGADEICDDGIDQDCDGEDAIDCEGPGDDGGPGDDGGPGDGPRMISGGCSVAHGASGSQLALAFAVVAIGLVIRRRRAGW
>NZ_CP011125.1|WP_053238575.1|10258399_10258735_+|hypothetical-protein
MRKHLMIGILSGLALGALSACESPRENAIDTQEEALDERMEAQEQQLEQEREQREQQLDTQQQQLDRELEQRQEALEQQHEMEEQRLEQTEEGVEERERNVQELENRPMAE
>NZ_CP011125.1|WP_053238576.1|10258910_10259240_-|ribosome-associated-translation-inhibitor-RaiA
MRMPVQIHFRDMDASEAMESLLREKLEGLAQIEPRATSCHVVIEPTDKRHRHGTIHRITVRLAVPGDELVVSRESGEDHSHEDPYVALRDAVDALRRQVVERNRMRRGA
>NZ_CP011125.1|WP_053238577.1|10259301_10260003_-|hypothetical-protein
MAYRDENDALRARIEQLERENAELRRERAHLRAPLRTTTTGERLLGAPLVLIEEREIDGALPASAHEEVLETLRAAFGAIGDGQSVGHTLTWRLGPPARQRIVEVIVTSREGRTRVRVLERLGTLAGGLFGGIVGGAGAGGAAVIAPLLALVDPVLALVSVPLWIGAVHAFVRAGYESTANARARELDGLTNEIERLVRHRVAQDVPKVRVDAKHDDDEHVTGATRAAERRAT
>NZ_CP011125.1|WP_053238578.1|10260047_10260554_+|hypothetical-protein
MSVPSADVPQAATKLGRIRATIEVLARAPSTGDDVATHAGMARRHAHYQLAAARALGWATREGARRHAITREGRALLATTPGSAAEVRRFVRAVRASPLVQALSQGIDPRAPDLEFAIADRIERLTAPPLAKETARERARTIAAWVRLAASPQEALAFAAGVAAEDTT

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP011125_9	9.1\|2174940\|49\|NZ_CP011125\|CRISPRCasFinder	2174940-2174988	49	NZ_CP011125.1	2175040-2175088	0	1.0
NZ_CP011125_15	15.7\|3330388\|18\|NZ_CP011125\|CRT	3330388-3330405	18	NZ_CP011125.1	86241-86258	1	0.944
NZ_CP011125_15	15.7\|3330388\|18\|NZ_CP011125\|CRT	3330388-3330405	18	NZ_CP011125.1	5427130-5427147	1	0.944
NZ_CP011125_15	15.8\|3330429\|18\|NZ_CP011125\|CRT	3330429-3330446	18	NZ_CP011125.1	86241-86258	1	0.944
NZ_CP011125_18	18.1\|3669787\|22\|NZ_CP011125\|CRISPRCasFinder	3669787-3669808	22	NZ_CP011125.1	268570-268591	1	0.955
NZ_CP011125_24	24.1\|6244246\|17\|NZ_CP011125\|CRISPRCasFinder	6244246-6244262	17	NZ_CP011125.1	1880191-1880207	1	0.941
NZ_CP011125_24	24.1\|6244246\|17\|NZ_CP011125\|CRISPRCasFinder	6244246-6244262	17	NZ_CP011125.1	3651456-3651472	1	0.941
NZ_CP011125_24	24.1\|6244246\|17\|NZ_CP011125\|CRISPRCasFinder	6244246-6244262	17	NZ_CP011125.1	7479976-7479992	1	0.941
NZ_CP011125_15	15.4\|3330263\|19\|NZ_CP011125\|CRT	3330263-3330281	19	NZ_CP011125.1	2895758-2895776	2	0.895
NZ_CP011125_15	15.5\|3330305\|19\|NZ_CP011125\|CRT	3330305-3330323	19	NZ_CP011125.1	3562156-3562174	2	0.895
NZ_CP011125_15	15.5\|3330305\|19\|NZ_CP011125\|CRT	3330305-3330323	19	NZ_CP011125.1	3578607-3578625	2	0.895
NZ_CP011125_17	17.2\|3669626\|19\|NZ_CP011125\|CRISPRCasFinder	3669626-3669644	19	NZ_CP011125.1	1305148-1305166	2	0.895
NZ_CP011125_39	39.1\|9835687\|22\|NZ_CP011125\|CRT	9835687-9835708	22	NZ_CP011125.1	6845168-6845189	2	0.909

1. spacer 9.1|2174940|49|NZ_CP011125|CRISPRCasFinder matches to position: 2175040-2175088, mismatch: 0, identity: 1.0

ggagttgccgctaaggagagcaggaggagcaggaggggattcgcgcgat	CRISPR spacer
ggagttgccgctaaggagagcaggaggagcaggaggggattcgcgcgat	Protospacer
*************************************************

2. spacer 15.7|3330388|18|NZ_CP011125|CRT matches to position: 86241-86258, mismatch: 1, identity: 0.944

gctggaagtcggcgtgga	CRISPR spacer
gctggaagtcggcgttga	Protospacer
*************** **

3. spacer 15.7|3330388|18|NZ_CP011125|CRT matches to position: 5427130-5427147, mismatch: 1, identity: 0.944

gctggaagtcggcgtgga	CRISPR spacer
gctggaggtcggcgtgga	Protospacer
******.***********

4. spacer 15.8|3330429|18|NZ_CP011125|CRT matches to position: 86241-86258, mismatch: 1, identity: 0.944

gctggaagtcggcgtcga	CRISPR spacer
gctggaagtcggcgttga	Protospacer
***************.**

5. spacer 18.1|3669787|22|NZ_CP011125|CRISPRCasFinder matches to position: 268570-268591, mismatch: 1, identity: 0.955

gcggcccgacgccgggatgcgc	CRISPR spacer
gcggcccgacgccgcgatgcgc	Protospacer
************** *******

6. spacer 24.1|6244246|17|NZ_CP011125|CRISPRCasFinder matches to position: 1880191-1880207, mismatch: 1, identity: 0.941

tccgcgcggtcgagcgg	CRISPR spacer
tccgcgcggccgagcgg	Protospacer
*********.*******

7. spacer 24.1|6244246|17|NZ_CP011125|CRISPRCasFinder matches to position: 3651456-3651472, mismatch: 1, identity: 0.941

tccgcgcggtcgagcgg	CRISPR spacer
tccgcgcgctcgagcgg	Protospacer
******** ********

8. spacer 24.1|6244246|17|NZ_CP011125|CRISPRCasFinder matches to position: 7479976-7479992, mismatch: 1, identity: 0.941

tccgcgcggtcgagcgg	CRISPR spacer
tccgcgccgtcgagcgg	Protospacer
******* *********

9. spacer 15.4|3330263|19|NZ_CP011125|CRT matches to position: 2895758-2895776, mismatch: 2, identity: 0.895

ctcgaaagtcgtcgggtga	CRISPR spacer
ctcgaacgtcgtcgcgtga	Protospacer
****** ******* ****

10. spacer 15.5|3330305|19|NZ_CP011125|CRT matches to position: 3562156-3562174, mismatch: 2, identity: 0.895

cttcgagctcgccccgcga	CRISPR spacer
cttcgagatcgcgccgcga	Protospacer
******* **** ******

11. spacer 15.5|3330305|19|NZ_CP011125|CRT matches to position: 3578607-3578625, mismatch: 2, identity: 0.895

cttcgagctcgccccgcga	CRISPR spacer
cttcgagctcgcggcgcga	Protospacer
************  *****

12. spacer 17.2|3669626|19|NZ_CP011125|CRISPRCasFinder matches to position: 1305148-1305166, mismatch: 2, identity: 0.895

gtccgatgcgggcccgacc	CRISPR spacer
gtcggatgcgggctcgacc	Protospacer
*** *********.*****

13. spacer 39.1|9835687|22|NZ_CP011125|CRT matches to position: 6845168-6845189, mismatch: 2, identity: 0.909

gtcccttcggtcgcgatcggtc	CRISPR spacer
gtcccttcgtgcgcgatcggtc	Protospacer
*********  ***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP011125_18	18.1\|3669787\|22\|NZ_CP011125\|CRISPRCasFinder	3669787-3669808	22	NC_006362	Nocardia farcinica IFM 10152 plasmid pNF1, complete sequence	160827-160848	1	0.955
NZ_CP011125_18	18.1\|3669787\|22\|NZ_CP011125\|CRISPRCasFinder	3669787-3669808	22	NZ_LN868941	Nocardia farcinica strain NCTC11134 plasmid 4, complete sequence	70993-71014	1	0.955
NZ_CP011125_18	18.1\|3669787\|22\|NZ_CP011125\|CRISPRCasFinder	3669787-3669808	22	NZ_CP031419	Nocardia farcinica strain W6977 plasmid unnamed1, complete sequence	12874-12895	1	0.955
NZ_CP011125_18	18.1\|3669787\|22\|NZ_CP011125\|CRISPRCasFinder	3669787-3669808	22	CP000385	Mycobacterium sp. MCS Plasmid1, complete sequence	205198-205219	1	0.955
NZ_CP011125_18	18.1\|3669787\|22\|NZ_CP011125\|CRISPRCasFinder	3669787-3669808	22	NZ_CP026745	Nocardia cyriacigeorgica strain MDA3349 isolate MDA3349 ancestor plasmid p_unnamed, complete sequence	103213-103234	1	0.955
NZ_CP011125_18	18.1\|3669787\|22\|NZ_CP011125\|CRISPRCasFinder	3669787-3669808	22	NC_008704	Mycobacterium sp. KMS plasmid pMKMS02, complete sequence	10383-10404	1	0.955
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NZ_CP016024	Ralstonia insidiosa strain ATCC 49129 plasmid pRI-1, complete sequence	30080-30110	6	0.806
NZ_CP011125_19	19.1\|4199047\|27\|NZ_CP011125\|CRISPRCasFinder	4199047-4199073	27	NZ_CP018096	Chelatococcus daeguensis strain TAD1 plasmid pTAD1, complete sequence	378259-378285	6	0.778
NZ_CP011125_19	19.1\|4199047\|27\|NZ_CP011125\|CRISPRCasFinder	4199047-4199073	27	NZ_CP024895	Amycolatopsis sp. AA4 plasmid unnamed1, complete sequence	273333-273359	6	0.778
NZ_CP011125_19	19.1\|4199047\|27\|NZ_CP011125\|CRISPRCasFinder	4199047-4199073	27	MN694130	Marine virus AFVG_250M413, complete genome	39598-39624	6	0.778
NZ_CP011125_34	34.3\|8911808\|30\|NZ_CP011125\|CRISPRCasFinder	8911808-8911837	30	NZ_CP017563	Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence	752573-752602	6	0.8
NZ_CP011125_43	43.3\|10251852\|33\|NZ_CP011125\|CRISPRCasFinder	10251852-10251884	33	NZ_CP013454	Burkholderia vietnamiensis strain MSMB608WGS plasmid pMSMB608, complete sequence	26177-26209	6	0.818
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NZ_LR134454	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence	144514-144544	7	0.774
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NZ_CP014964	Geobacter anodireducens strain SD-1 plasmid pSD, complete sequence	84116-84146	7	0.774
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NZ_CP009645	Bacillus pseudomycoides strain BTZ plasmid pBTZ_5, complete sequence	3365-3395	7	0.774
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NZ_CP034352	Streptomyces sp. W1SF4 plasmid p2, complete sequence	173024-173054	7	0.774
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	791167-791197	7	0.774
NZ_CP011125_20	20.2\|4502328\|32\|NZ_CP011125\|CRISPRCasFinder	4502328-4502359	32	NZ_CP014519	Sinomonas atrocyanea strain KCTC 3377 plasmid pSA01, complete sequence	22536-22567	7	0.781
NZ_CP011125_26	26.1\|7071566\|31\|NZ_CP011125\|CRISPRCasFinder	7071566-7071596	31	NZ_CP029831	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence	490221-490251	7	0.774
NZ_CP011125_26	26.2\|7071620\|31\|NZ_CP011125\|CRISPRCasFinder	7071620-7071650	31	NZ_LR134454	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence	13814-13844	7	0.774
NZ_CP011125_34	34.3\|8911808\|30\|NZ_CP011125\|CRISPRCasFinder	8911808-8911837	30	NZ_CP020447	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed7, complete sequence	66297-66326	7	0.767
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP022775	Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence	164386-164418	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	170491-170523	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP022762	Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence	184849-184881	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP014703	Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence	184849-184881	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP022760	Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence	174355-174387	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP022789	Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence	174356-174388	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP022771	Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence	184858-184890	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP022777	Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence	184876-184908	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP022799	Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence	184848-184880	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP022764	Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence	164401-164433	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP022797	Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence	164400-164432	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP022758	Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence	164398-164430	7	0.788
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP012748	Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence	63419-63451	7	0.788
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NC_013859	Azospirillum sp. B510 plasmid pAB510e, complete sequence	357734-357764	8	0.742
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NZ_CP054617	Azospirillum oryzae strain KACC 14407 plasmid unnamed3, complete sequence	615676-615706	8	0.742
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NZ_CP022999	Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-A, complete sequence	725494-725524	8	0.742
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NC_020062	Rhizobium tropici CIAT 899 plasmid pRtrCIAT899c, complete sequence	657973-658003	8	0.742
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NZ_AP022319	Burkholderia sp. THE68 plasmid BTHE68_p1, complete sequence	264585-264615	8	0.742
NZ_CP011125_20	20.2\|4502328\|32\|NZ_CP011125\|CRISPRCasFinder	4502328-4502359	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	5026194-5026225	8	0.75
NZ_CP011125_20	20.2\|4502328\|32\|NZ_CP011125\|CRISPRCasFinder	4502328-4502359	32	NC_023316	Streptomyces sp. 14R-10 plasmid pZL1, complete sequence	91555-91586	8	0.75
NZ_CP011125_20	20.2\|4502328\|32\|NZ_CP011125\|CRISPRCasFinder	4502328-4502359	32	NZ_CP033072	Streptomyces sp. Z022 plasmid unnamed1	45165-45196	8	0.75
NZ_CP011125_20	20.2\|4502328\|32\|NZ_CP011125\|CRISPRCasFinder	4502328-4502359	32	NZ_CP023072	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence	158121-158152	8	0.75
NZ_CP011125_20	20.2\|4502328\|32\|NZ_CP011125\|CRISPRCasFinder	4502328-4502359	32	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	687038-687069	8	0.75
NZ_CP011125_26	26.1\|7071566\|31\|NZ_CP011125\|CRISPRCasFinder	7071566-7071596	31	NC_021289	Burkholderia insecticola plasmid p1, complete sequence	323179-323209	8	0.742
NZ_CP011125_26	26.1\|7071566\|31\|NZ_CP011125\|CRISPRCasFinder	7071566-7071596	31	NC_019320	Variovorax sp. DB1 plasmid pDB1, complete sequence	14016-14046	8	0.742
NZ_CP011125_26	26.1\|7071566\|31\|NZ_CP011125\|CRISPRCasFinder	7071566-7071596	31	NZ_CP015530	Rhodococcus sp. WB1 plasmid pWB1, complete sequence	46743-46773	8	0.742
NZ_CP011125_34	34.3\|8911808\|30\|NZ_CP011125\|CRISPRCasFinder	8911808-8911837	30	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	423189-423218	8	0.733
NZ_CP011125_34	34.3\|8911808\|30\|NZ_CP011125\|CRISPRCasFinder	8911808-8911837	30	AP014720	Arthrobacter sp. Hiyo8 plasmid pHiyo8-1 DNA, complete genome, strain: Hiyo8	99259-99288	8	0.733
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP012399	Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence	786063-786095	8	0.758
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	260038-260070	8	0.758
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP013104	Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence	1778062-1778094	8	0.758
NZ_CP011125_43	43.3\|10251852\|33\|NZ_CP011125\|CRISPRCasFinder	10251852-10251884	33	NZ_CP034813	Paracoccus sp. Arc7-R13 plasmid unnamed2, complete sequence	190391-190423	8	0.758
NZ_CP011125_4	4.2\|782755\|31\|NZ_CP011125\|CRISPRCasFinder	782755-782785	31	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	222266-222296	9	0.71
NZ_CP011125_20	20.2\|4502328\|32\|NZ_CP011125\|CRISPRCasFinder	4502328-4502359	32	MH509446	Gordonia phage DelRio, complete genome	6214-6245	9	0.719
NZ_CP011125_20	20.2\|4502328\|32\|NZ_CP011125\|CRISPRCasFinder	4502328-4502359	32	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	347640-347671	9	0.719
NZ_CP011125_20	20.2\|4502328\|32\|NZ_CP011125\|CRISPRCasFinder	4502328-4502359	32	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	791543-791574	9	0.719
NZ_CP011125_26	26.1\|7071566\|31\|NZ_CP011125\|CRISPRCasFinder	7071566-7071596	31	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	892105-892135	9	0.71
NZ_CP011125_26	26.1\|7071566\|31\|NZ_CP011125\|CRISPRCasFinder	7071566-7071596	31	NC_009956	Dinoroseobacter shibae DFL 12 = DSM 16493 plasmid pDSHI02, complete sequence	123173-123203	9	0.71
NZ_CP011125_26	26.1\|7071566\|31\|NZ_CP011125\|CRISPRCasFinder	7071566-7071596	31	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1240273-1240303	9	0.71
NZ_CP011125_26	26.1\|7071566\|31\|NZ_CP011125\|CRISPRCasFinder	7071566-7071596	31	NZ_CP025513	Neorhizobium sp. SOG26 plasmid unnamed2, complete sequence	950268-950298	9	0.71
NZ_CP011125_26	26.1\|7071566\|31\|NZ_CP011125\|CRISPRCasFinder	7071566-7071596	31	NC_013855	Azospirillum sp. B510 plasmid pAB510a, complete sequence	1284060-1284090	9	0.71
NZ_CP011125_34	34.3\|8911808\|30\|NZ_CP011125\|CRISPRCasFinder	8911808-8911837	30	NZ_CP020539	Sphingobium herbicidovorans strain MH plasmid pMSHV, complete sequence	936229-936258	9	0.7
NZ_CP011125_34	34.3\|8911808\|30\|NZ_CP011125\|CRISPRCasFinder	8911808-8911837	30	NZ_CP015040	Rhodovulum sp. P5 plasmid pRGUI01, complete sequence	60354-60383	9	0.7
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	NZ_CP015293	Rhodobacter sphaeroides strain MBTLJ-20 plasmid e, complete sequence	14680-14712	9	0.727
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	MH834623	Arthrobacter phage Peas, complete genome	29987-30019	9	0.727
NZ_CP011125_26	26.1\|7071566\|31\|NZ_CP011125\|CRISPRCasFinder	7071566-7071596	31	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	360757-360787	10	0.677
NZ_CP011125_43	43.1\|10251726\|33\|NZ_CP011125\|CRISPRCasFinder	10251726-10251758	33	MH834605	Arthrobacter phage Constance, complete genome	29762-29794	10	0.697
NZ_CP011125_20	20.2\|4502328\|32\|NZ_CP011125\|CRISPRCasFinder	4502328-4502359	32	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	509480-509511	11	0.656
NZ_CP011125_36	36.1\|9143004\|37\|NZ_CP011125\|CRISPRCasFinder	9143004-9143040	37	NZ_CP012477	Arthrobacter sp. ERGS1:01 isolate water plasmid unnamed2, complete sequence	298372-298408	11	0.703

1. spacer 18.1|3669787|22|NZ_CP011125|CRISPRCasFinder matches to NC_006362 (Nocardia farcinica IFM 10152 plasmid pNF1, complete sequence) position: , mismatch: 1, identity: 0.955

gcggcccgacgccgggatgcgc	CRISPR spacer
gcggcccgacgccgggaagcgc	Protospacer
***************** ****

2. spacer 18.1|3669787|22|NZ_CP011125|CRISPRCasFinder matches to NZ_LN868941 (Nocardia farcinica strain NCTC11134 plasmid 4, complete sequence) position: , mismatch: 1, identity: 0.955

gcggcccgacgccgggatgcgc	CRISPR spacer
gcggcccgacgccgggaagcgc	Protospacer
***************** ****

3. spacer 18.1|3669787|22|NZ_CP011125|CRISPRCasFinder matches to NZ_CP031419 (Nocardia farcinica strain W6977 plasmid unnamed1, complete sequence) position: , mismatch: 1, identity: 0.955

gcggcccgacgccgggatgcgc	CRISPR spacer
gcggcccgacgccgggaagcgc	Protospacer
***************** ****

4. spacer 18.1|3669787|22|NZ_CP011125|CRISPRCasFinder matches to CP000385 (Mycobacterium sp. MCS Plasmid1, complete sequence) position: , mismatch: 1, identity: 0.955

gcggcccgacgccgggatgcgc	CRISPR spacer
gcggcccgacgccgggatacgc	Protospacer
******************.***

5. spacer 18.1|3669787|22|NZ_CP011125|CRISPRCasFinder matches to NZ_CP026745 (Nocardia cyriacigeorgica strain MDA3349 isolate MDA3349 ancestor plasmid p_unnamed, complete sequence) position: , mismatch: 1, identity: 0.955

gcggcccgacgccgggatgcgc	CRISPR spacer
gcggcccgacgccgggaagcgc	Protospacer
***************** ****

6. spacer 18.1|3669787|22|NZ_CP011125|CRISPRCasFinder matches to NC_008704 (Mycobacterium sp. KMS plasmid pMKMS02, complete sequence) position: , mismatch: 1, identity: 0.955

gcggcccgacgccgggatgcgc	CRISPR spacer
gcggcccgacgccgggatacgc	Protospacer
******************.***

7. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP016024 (Ralstonia insidiosa strain ATCC 49129 plasmid pRI-1, complete sequence) position: , mismatch: 6, identity: 0.806

--gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
gcgccctg--acggcaccgccgcgaagcaacag	Protospacer
  *.* **  .***************** ****

8. spacer 19.1|4199047|27|NZ_CP011125|CRISPRCasFinder matches to NZ_CP018096 (Chelatococcus daeguensis strain TAD1 plasmid pTAD1, complete sequence) position: , mismatch: 6, identity: 0.778

gcgcaggatgacccggtggaagccgag	CRISPR spacer
gcgcaggatgtcgcggtggaagcgcca	Protospacer
********** * **********   .

9. spacer 19.1|4199047|27|NZ_CP011125|CRISPRCasFinder matches to NZ_CP024895 (Amycolatopsis sp. AA4 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

gcgcaggatgacccggtggaagccgag	CRISPR spacer
ctgcaggatgcccaggtggaagccgcc	Protospacer
 .******** ** ***********

10. spacer 19.1|4199047|27|NZ_CP011125|CRISPRCasFinder matches to MN694130 (Marine virus AFVG_250M413, complete genome) position: , mismatch: 6, identity: 0.778

gcgcaggatgacccggtggaagccgag	CRISPR spacer
gtgcagaatgacccggtggaagcacct	Protospacer
*.****.****************

11. spacer 34.3|8911808|30|NZ_CP011125|CRISPRCasFinder matches to NZ_CP017563 (Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence) position: , mismatch: 6, identity: 0.8

gagctccgcctcggggcggcagcccgcgca	CRISPR spacer
gatctccgcctcggggcggcggcgcacccg	Protospacer
** *****************.** *.* *.

12. spacer 43.3|10251852|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP013454 (Burkholderia vietnamiensis strain MSMB608WGS plasmid pMSMB608, complete sequence) position: , mismatch: 6, identity: 0.818

tcgcaggccacgccgctccgcacccgtgccggc-	CRISPR spacer
tcgtaggcctcgccgctccgcacct-cgccgacg	Protospacer
***.***** **************. .****.*

13. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NZ_LR134454 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence) position: , mismatch: 7, identity: 0.774

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
gtcgtggcgcggccccgccgcgaacgaggcg	Protospacer
************* **********   .  *

14. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP014964 (Geobacter anodireducens strain SD-1 plasmid pSD, complete sequence) position: , mismatch: 7, identity: 0.774

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
gcggtatcgcggcaccgccgctaagccacca	Protospacer
*. **. ************** ******* .

15. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP009645 (Bacillus pseudomycoides strain BTZ plasmid pBTZ_5, complete sequence) position: , mismatch: 7, identity: 0.774

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
ggcatggcgcggcaccgccgccaagcgtcgc	Protospacer
* *.***************** ****  *.

16. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP034352 (Streptomyces sp. W1SF4 plasmid p2, complete sequence) position: , mismatch: 7, identity: 0.774

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
gtcgtggcgcagcaccgcggcgatgtccgtg	Protospacer
**********.******* **** *.*   *

17. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 7, identity: 0.774

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
gtcgtcgcgcagcaccgccgcgaccgcatcg	Protospacer
***** ****.************   **. *

18. spacer 20.2|4502328|32|NZ_CP011125|CRISPRCasFinder matches to NZ_CP014519 (Sinomonas atrocyanea strain KCTC 3377 plasmid pSA01, complete sequence) position: , mismatch: 7, identity: 0.781

gacggtcgacgagggcaccgcgaccg-cgacgc	CRISPR spacer
cccggtcgacgagggcaccctgaccaccggcg-	Protospacer
  ***************** .****. **.**

19. spacer 26.1|7071566|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP029831 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence) position: , mismatch: 7, identity: 0.774

-gcgtccgccggtcgacggcgcgatgacggat	CRISPR spacer
cgcg-acgccggtcgccagcgcgatgacgtcg	Protospacer
 ***  ********* *.***********

20. spacer 26.2|7071620|31|NZ_CP011125|CRISPRCasFinder matches to NZ_LR134454 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence) position: , mismatch: 7, identity: 0.774

cgcttcgctcgacgccgacacgtcctcggac	CRISPR spacer
cgcggggctcgacgccgccacgtcgtcggtg	Protospacer
***   *********** ****** ****

21. spacer 34.3|8911808|30|NZ_CP011125|CRISPRCasFinder matches to NZ_CP020447 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed7, complete sequence) position: , mismatch: 7, identity: 0.767

gagctccgcctcggggcggcagcccgcgca	CRISPR spacer
ctgcgacgcctcggggcggcagatcgcgct	Protospacer
  **  **************** .*****

22. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022775 (Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

23. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

24. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022762 (Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

25. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP014703 (Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

26. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022760 (Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

27. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022789 (Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

28. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022771 (Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

29. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022777 (Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

30. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022799 (Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

31. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022764 (Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

32. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022797 (Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

33. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022758 (Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
tgccagctccagccgctgcgcagccgcctcggc	Protospacer
  *******  *******************

34. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP012748 (Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
gatcagctcgcgcagcttcgcagccgccccagg	Protospacer
* .********** *** **********.*  *

35. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NC_013859 (Azospirillum sp. B510 plasmid pAB510e, complete sequence) position: , mismatch: 8, identity: 0.742

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
gaaatcgcgcgacaccgccgcgaagccagga	Protospacer
*  .* *****.**************** ..

36. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP054617 (Azospirillum oryzae strain KACC 14407 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.742

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
ctgatggcgcggcaccgccgccaagcgcttg	Protospacer
 * .***************** ****  . *

37. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP022999 (Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-A, complete sequence) position: , mismatch: 8, identity: 0.742

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
gttcgggggcggcaccgccgggaagccaggt	Protospacer
**.  ** ************ ******* .

38. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NC_020062 (Rhizobium tropici CIAT 899 plasmid pRtrCIAT899c, complete sequence) position: , mismatch: 8, identity: 0.742

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
gttcgggggcggcaccgccgggaagccaggt	Protospacer
**.  ** ************ ******* .

39. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NZ_AP022319 (Burkholderia sp. THE68 plasmid BTHE68_p1, complete sequence) position: , mismatch: 8, identity: 0.742

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
gagctggcgcggccccggcgcgaagccgaac	Protospacer
*   ********* *** *********. *

40. spacer 20.2|4502328|32|NZ_CP011125|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.75

gacggtcgacgagggcaccgcgaccgcgacgc	CRISPR spacer
gcagatcgccgacggcaccgcgaccgcggcca	Protospacer
*  *.*** *** ***************.*

41. spacer 20.2|4502328|32|NZ_CP011125|CRISPRCasFinder matches to NC_023316 (Streptomyces sp. 14R-10 plasmid pZL1, complete sequence) position: , mismatch: 8, identity: 0.75

gacggtcgacgagggcaccgcgaccgcgacgc	CRISPR spacer
caccaccgccgaggccaccgcgaccgcgaccg	Protospacer
 ** ..** ***** ***************

42. spacer 20.2|4502328|32|NZ_CP011125|CRISPRCasFinder matches to NZ_CP033072 (Streptomyces sp. Z022 plasmid unnamed1) position: , mismatch: 8, identity: 0.75

gacggtcgacgagggcaccgcgaccgcgacgc	CRISPR spacer
cgggatcgacgagggcagcgagaccgcgaagt	Protospacer
 . *.************ ** ******** *.

43. spacer 20.2|4502328|32|NZ_CP011125|CRISPRCasFinder matches to NZ_CP023072 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence) position: , mismatch: 8, identity: 0.75

gacggtcgacgagggcaccgcgaccgcgacgc	CRISPR spacer
ggcggtcgacgagggcaaggcgaccgaggaag	Protospacer
*.***************  ******* *. .

44. spacer 20.2|4502328|32|NZ_CP011125|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.75

gacggtcgacgagggcaccgcgaccgcgacgc	CRISPR spacer
gtcgaagaacgacggcgccgcgaccgcgacga	Protospacer
* **.  .**** ***.**************

45. spacer 26.1|7071566|31|NZ_CP011125|CRISPRCasFinder matches to NC_021289 (Burkholderia insecticola plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.742

gcgtccgccggtcgacggcgcgatgacggat	CRISPR spacer
ttgcccgccggtcgccagcgcgatgacgttc	Protospacer
 .*.********** *.***********  .

46. spacer 26.1|7071566|31|NZ_CP011125|CRISPRCasFinder matches to NC_019320 (Variovorax sp. DB1 plasmid pDB1, complete sequence) position: , mismatch: 8, identity: 0.742

gcgtccgccggtcgacggcgcgatgacggat	CRISPR spacer
cctgctgccggtggacggcgcgatcacggcc	Protospacer
 *  *.****** *********** **** .

47. spacer 26.1|7071566|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP015530 (Rhodococcus sp. WB1 plasmid pWB1, complete sequence) position: , mismatch: 8, identity: 0.742

gcgtccgccggtcgacggcgcgatgacggat	CRISPR spacer
ccctcagccggtcgacggcgcgctgagattt	Protospacer
 * ** **************** *** .  *

48. spacer 34.3|8911808|30|NZ_CP011125|CRISPRCasFinder matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 8, identity: 0.733

gagctccgcctcggggcggcagcccgcgca	CRISPR spacer
accgcccgcatcggggcggcggcccgcgcc	Protospacer
.   .**** **********.********

49. spacer 34.3|8911808|30|NZ_CP011125|CRISPRCasFinder matches to AP014720 (Arthrobacter sp. Hiyo8 plasmid pHiyo8-1 DNA, complete genome, strain: Hiyo8) position: , mismatch: 8, identity: 0.733

gagctccgcctcggggcggcagcccgcgca	CRISPR spacer
gctatccgcctcggggcggcagaacgcatt	Protospacer
*   ******************  ***..

50. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP012399 (Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence) position: , mismatch: 8, identity: 0.758

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
ggtgagctccggccgctgcgcagccgcctcgac	Protospacer
* . *****  *******************

51. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 8, identity: 0.758

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
ttccagcacgcgccgcagcgcagccgcattcca	Protospacer
 .***** ******** ********** *..*.

52. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP013104 (Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.758

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
gatcagctcgcgcagcttcgcagccgcgcccgg	Protospacer
* .********** *** ********* .*. *

53. spacer 43.3|10251852|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP034813 (Paracoccus sp. Arc7-R13 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.758

tcgcaggccacgccgctccgcacccgtgccggc	CRISPR spacer
accatggccacgccgttccgcacccgtcccgag	Protospacer
 *   **********.*********** ***.

54. spacer 4.2|782755|31|NZ_CP011125|CRISPRCasFinder matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 9, identity: 0.71

gtcgtggcgcggcaccgccgcgaagccacag	CRISPR spacer
cgagtggcgcggcaccggcgcggagctgcgc	Protospacer
   ************** ****.***..*.

55. spacer 20.2|4502328|32|NZ_CP011125|CRISPRCasFinder matches to MH509446 (Gordonia phage DelRio, complete genome) position: , mismatch: 9, identity: 0.719

gacggtcgacgagggcaccgcgaccgcgacgc	CRISPR spacer
ggtcaacgccgagggcaccgagaccgcgaccg	Protospacer
*.. . ** *********** *********

56. spacer 20.2|4502328|32|NZ_CP011125|CRISPRCasFinder matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 9, identity: 0.719

gacggtcgacgagggcaccgcgaccgcgacgc	CRISPR spacer
ggcggccgacaagggcaccgcgaccttctccg	Protospacer
*.***.****.************** .  *

57. spacer 20.2|4502328|32|NZ_CP011125|CRISPRCasFinder matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 9, identity: 0.719

gacggtcgacgagggcaccgcgaccgcgacgc	CRISPR spacer
gctcgtcgacgagggcagcgcggccgctccag	Protospacer
* . ************* ****.****  *.

58. spacer 26.1|7071566|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.71

gcgtccgccggtcgacggcgcgatgacggat	CRISPR spacer
cttgccgccggtcgacggggcgatgaagccg	Protospacer
 .  ************** ******* *

59. spacer 26.1|7071566|31|NZ_CP011125|CRISPRCasFinder matches to NC_009956 (Dinoroseobacter shibae DFL 12 = DSM 16493 plasmid pDSHI02, complete sequence) position: , mismatch: 9, identity: 0.71

gcgtccgccggtcgacggcgcgatgacggat	CRISPR spacer
cgaaccgccggtcgacggcgcaatgatcggc	Protospacer
  . *****************.****. *..

60. spacer 26.1|7071566|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 9, identity: 0.71

gcgtccgccggtcgacggcgcgatgacggat	CRISPR spacer
cttgccgccggtcgacggggcgatgaagccg	Protospacer
 .  ************** ******* *

61. spacer 26.1|7071566|31|NZ_CP011125|CRISPRCasFinder matches to NZ_CP025513 (Neorhizobium sp. SOG26 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.71

gcgtccgccggtcgacggcgcgatgacggat	CRISPR spacer
ctcgccgccggtcaaccgcgcgatgaccgcg	Protospacer
 .  *********.** ********** *

62. spacer 26.1|7071566|31|NZ_CP011125|CRISPRCasFinder matches to NC_013855 (Azospirillum sp. B510 plasmid pAB510a, complete sequence) position: , mismatch: 9, identity: 0.71

gcgtccgccggtcgacggcgcgatgacggat	CRISPR spacer
ggcgacgccggtcgccagcgcgatgacgtcg	Protospacer
*    ********* *.***********

63. spacer 34.3|8911808|30|NZ_CP011125|CRISPRCasFinder matches to NZ_CP020539 (Sphingobium herbicidovorans strain MH plasmid pMSHV, complete sequence) position: , mismatch: 9, identity: 0.7

gagctccgcctcggggcggcagcccgcgca	CRISPR spacer
gcagcgagccgcggggcggcagcccgcgtg	Protospacer
* . .  *** *****************..

64. spacer 34.3|8911808|30|NZ_CP011125|CRISPRCasFinder matches to NZ_CP015040 (Rhodovulum sp. P5 plasmid pRGUI01, complete sequence) position: , mismatch: 9, identity: 0.7

gagctccgcctcggggcggcagcccgcgca	CRISPR spacer
ctatatcgcatcggggcgggagcccgcgcg	Protospacer
  .. .*** ********* *********.

65. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to NZ_CP015293 (Rhodobacter sphaeroides strain MBTLJ-20 plasmid e, complete sequence) position: , mismatch: 9, identity: 0.727

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
caccagctcgcgcagccgcgcagccgtcgccgc	Protospacer
  *********** **.*********.* *.

66. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to MH834623 (Arthrobacter phage Peas, complete genome) position: , mismatch: 9, identity: 0.727

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
gcccagctcgcgcatctgcgcagcggtgatgct	Protospacer
*************  ********* *.  . *

67. spacer 26.1|7071566|31|NZ_CP011125|CRISPRCasFinder matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 10, identity: 0.677

gcgtccgccggtcgacggcgcgatgacggat	CRISPR spacer
ccggccgccggtcaacggcgcgattgtcctg	Protospacer
 ** *********.********** ..

68. spacer 43.1|10251726|33|NZ_CP011125|CRISPRCasFinder matches to MH834605 (Arthrobacter phage Constance, complete genome) position: , mismatch: 10, identity: 0.697

gcccagctcgcgccgctgcgcagccgcctctcg	CRISPR spacer
gcccagctcgcgcatctgcgcagcggtgatgat	Protospacer
*************  ********* *.  .

69. spacer 20.2|4502328|32|NZ_CP011125|CRISPRCasFinder matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 11, identity: 0.656

gacggtcgacgagggcaccgcgaccgcgacgc	CRISPR spacer
cgaactcgacgaggtcaccgcgagcgcggaca	Protospacer
 . . ********* ******** ****.

70. spacer 36.1|9143004|37|NZ_CP011125|CRISPRCasFinder matches to NZ_CP012477 (Arthrobacter sp. ERGS1:01 isolate water plasmid unnamed2, complete sequence) position: , mismatch: 11, identity: 0.703

atcgacgcaggcgccgccgcggcagcgctcgccgggc	CRISPR spacer
gacgacgccgacgccgccgcggcagcgcaggttgttg	Protospacer
. ****** *.*****************  *..*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

5633703 : 5667693

Microbacterium_phage(25.0%)

protease,tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_053234937.1\|5633703_5634234_-\|tail	phage tail protein	A0A2R4A082	Microbacterium_phage	6.3e-12	32.7
WP_053234938.1\|5634247_5634754_-\|tail	phage tail protein	A0A222ZG41	Arthrobacter_phage	1.9e-18	38.4
WP_053234939.1\|5634773_5635283_-\|tail	phage tail protein	A0A2R3ZZT3	Microbacterium_phage	3.6e-12	34.0
WP_053234940.1\|5635304_5640071_-	putative Ig domain-containing protein	NA	NA	NA	NA
WP_053234941.1\|5640249_5641095_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_053234942.1\|5641094_5642369_+	VCBS repeat-containing protein	NA	NA	NA	NA
WP_053234943.1\|5642442_5643720_-	DUF4340 domain-containing protein	NA	NA	NA	NA
WP_053234944.1\|5643732_5645505_-	GldG family protein	NA	NA	NA	NA
WP_053234945.1\|5645508_5646219_-	ABC transporter permease	NA	NA	NA	NA
WP_053238930.1\|5646218_5647274_-	ATP-binding cassette domain-containing protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	5.5e-15	25.7
WP_053234946.1\|5647477_5648233_-	extensin family protein	NA	NA	NA	NA
WP_169791532.1\|5648428_5651752_+	hypothetical protein	NA	NA	NA	NA
WP_053234948.1\|5651839_5652925_+\|protease	trypsin-like serine protease	NA	NA	NA	NA
WP_157069332.1\|5652974_5653676_+	hypothetical protein	NA	NA	NA	NA
WP_053234950.1\|5653676_5654342_-	hypothetical protein	NA	NA	NA	NA
WP_053234951.1\|5654366_5655155_-	ABC transporter permease	NA	NA	NA	NA
WP_053234952.1\|5655151_5656216_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.8e-18	27.4
WP_053234953.1\|5656212_5657112_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_053234954.1\|5657151_5657598_-	DUF962 domain-containing protein	NA	NA	NA	NA
WP_053234955.1\|5657594_5658410_-	hypothetical protein	NA	NA	NA	NA
WP_053234956.1\|5658548_5661965_+\|protease	ATP-dependent Clp protease ATP-binding subunit	A0A223W0B1	Agrobacterium_phage	1.9e-48	27.2
WP_053234957.1\|5661961_5665423_+	AAA family ATPase	A0A1L2CUT6	Pectobacterium_phage	5.0e-65	31.1
WP_053238931.1\|5665419_5667693_+\|protease	ATP-dependent Clp protease ATP-binding subunit	A0A248SJW6	Salicola_phage	5.6e-57	28.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP011125

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CRISPR-Cas detection and classification

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