CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP012476	Alkalihalobacillus clausii strain ENTPro plasmid unnamed, complete sequence	1 crisprs	NA	0	1	0	0
NZ_CP012475	Alkalihalobacillus clausii strain ENTPro chromosome, complete genome	14 crisprs	cas3,csa3,DEDDh,WYL,cas6,PD-DExK,cas10,csm3gr7,csx19,casR,DinG	1	7	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012476_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012476_1

2314-2430

Orphan

Consensus_repeat	Method
TAATGAACGGAATGTAACCGAGACTGTCAACCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012476_1

>merge|NZ_CP012476|1|2314-2430|CRISPRCasFinder
TAATGAACGGAATGTAACCGAGACTGTCAACCAAACAACGAGAAACAATGAAACGATTAATCGCCAGAACATCCAGAATAACAATAATGAACGGAATGTAACCGAGACTGTCAACCA

>NZ_CP012476|1|1|2314-2430|CRISPRCasFinder
TAATGAACGGAATGTAACCGAGACTGTCAACCA	AACAACGAGAAACAATGAAACGATTAATCGCCAGAACATCCAGAATAACAA
TAATGAACGGAATGTAACCGAGACTGTCAACCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012476.1\|WP_035202650.1\|6728_7043_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012476.1\|WP_035202649.1\|6286_6586_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012476.1\|WP_035202651.1\|7143_7344_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012476.1\|WP_051881150.1\|7377_7884_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NZ_CP012476.1\|WP_082369310.1\|5912_6065_+\|aspartyl-phosphate-phosphatase-Spo0E-family-protein	unknown	unknown	gnl\|CDD\|378175
NZ_CP012476.1\|WP_082369308.1\|3383_4577_+\|bifunctional-lytic-transglycosylase/C40-family-peptidase	unknown	unknown	gnl\|CDD\|381602
NZ_CP012476.1\|WP_035202644.1\|2755_3397_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012476.1\|WP_035202645.1\|4722_5346_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP012476.1\|WP_035202647.1\|5459_5654_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012476.1\|WP_035202653.1\|7914_8490_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP012476.1\|WP_082369308.1\|3383_4577_+\|bifunctional-lytic-transglycosylase/C40-family-peptidase	gnl\|CDD\|381602	cd13399, Slt35-like, Slt35-like lytic transglycosylase. Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	1.28093e-29
NZ_CP012476.1\|WP_035202645.1\|4722_5346_+\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	4.77803e-32
NZ_CP012476.1\|WP_051881150.1\|7377_7884_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	9.82275e-35
NZ_CP012476.1\|WP_082369310.1\|5912_6065_+\|aspartyl-phosphate-phosphatase-Spo0E-family-protein	gnl\|CDD\|378175	pfam09388, SpoOE-like, Spo0E like sporulation regulatory protein. Spore formation is an extreme response to starvation and can also be a component of disease transmission. Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A. Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation. This is a family of Spo0E-like phosphatases. The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure.	2.85496e-09

>NZ_CP012476.1|WP_035202644.1|2755_3397_+|hypothetical-protein
MFGWDFENSKADRVKLFLFLFVIFLIVGFSASLIIRSLSSDANIDDNNEVTEAKGDSEADSTLEVDFGSEEPVVENEQVENEFDQTEHFSEENLEETKEIAVDFVKAYHSYDSDNPSDYLENAQPYMTEALYQEFSAQPRRETLERSYLTVKETQVTNVVNSSSRVIRWNIIVLGEAESVDGEISETEDWYLVGLRQVDGEWKVEDVRVNVPN
>NZ_CP012476.1|WP_082369308.1|3383_4577_+|bifunctional-lytic-transglycosylase/C40-family-peptidase
MSQTDPNNDHQTEGSSALKKAASSAGKAATKKAVKTAAKKAAQKAAGTTLLAKIGWPIILGAFLLLLIAGAALIIIFIAASHEESSPQPGGGFWGGDISELAENEIPADFIPIYKAAEQEYGVPWNLLAAIHRVETHFSTIDPMVSPVGAVGHMQFMPCTWLGWGHPSCGGLGAGNIDNSQLVNVSVINKYGGYGVDANGDGKADPFDLEDAIFSAANYLAANGAAEGDFRRAAFAYNRADWYVEKVMGYADSYVSGYVPIGDGGGSGGNDVVNVGKKWIGNSKYVFGGGRNQADIAAGRFDCSSFVHWAFAQVGVDLGPLGSTSTETLKHLGTPVPPNEMKPGDLVFFDTYKIDGHVGIYVGDGKYIGAQSSTGVAIVDMTKGYWAKTFNGRVKRI
>NZ_CP012476.1|WP_035202645.1|4722_5346_+|recombinase-family-protein
MIFGYARVSSQEQNLDRQIEELQAVGCDKIYFDKQSGKNFSRAAFREMRSKMRFGDVLIVHDLSRFGRNKKEIKREWESLIADDIDIVVLDMPILDTRKYKELEGIGQLVRDIVLALLAWMVDQERLNTRKAQREGIEIAKRKGKYKGGKRKYHPGAKGKDKVIYDEVVRLLKCGESVMDIHRATGLARNTIYSIKKDLIHNRKEDD
>NZ_CP012476.1|WP_035202647.1|5459_5654_-|hypothetical-protein
MGRFTIRKAKWENVNLKSSRMAAILAFDLSFFGSFGTAASAANESGTYGLLAKYELTGRGYRVI
>NZ_CP012476.1|WP_082369310.1|5912_6065_+|aspartyl-phosphate-phosphatase-Spo0E-family-protein
MSLKEKIETKRKQMADLVRKNGVASKEVLKASQELDTLINQAMREGMMKQ
>NZ_CP012476.1|WP_035202649.1|6286_6586_+|hypothetical-protein
MKKNAVKFYEVENFRFYRLPSPISVAPDGWKFEPTRYALLSNTTDKRAIFLMNFNRGYSEVDLINDVVGCIKIHKIIHEADVSKDDQQLISELLEINGY
>NZ_CP012476.1|WP_035202650.1|6728_7043_+|hypothetical-protein
MKLILALLKLIEIFFIYVIPLGLAPSLILVNVTLNRVYGLKIYAVELLLLFSVSILIGYAVGSARDEYKKHLYRVYCKKRGIDPKKLSSWNDWKYNQILEKKSD
>NZ_CP012476.1|WP_035202651.1|7143_7344_+|hypothetical-protein
MFEVFFDDVLNSWVMAKSICRMCGSYTEFDSFESEEEALNAASEKTKLGERVDVIICEECFMENMY
>NZ_CP012476.1|WP_051881150.1|7377_7884_+|thermonuclease-family-protein
MNRIIIVFLFAIVLAGCEGTFDAEKGETTQGGELLQGVVTKVTDGDTFTVELNGVEEKVRPILVDAPEICHRNSPKDCEAEPFGDEATIFAEELLLDEIVYLEPDVSERDRYDRMLFYVYLEDGRMFQELLLAEGLAEVAVFEPDIKYMDEFFKIQEQAQKEKVGIWE
>NZ_CP012476.1|WP_035202653.1|7914_8490_+|hypothetical-protein
MEFIFSERPNNIFYGDICKINGQGCLIFGFGKSEAAQIASSDNMIAYDMACLTRDDEGTLYGHFEMEARAKGIDDPIKERIEIKNFLRMLDQEETQRLLDLNPHLKAIDGLVEIPYDAFVASCTYNITFTAPADFPFRPEGLPEIERDPQKRIKHFIKLSKDSNVRSFVVPWTDTVEEKAVLIKDALIQKK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012476_1	1.1\|2347\|51\|NZ_CP012476\|CRISPRCasFinder	2347-2397	51	NZ_CP012476	Bacillus clausii strain ENTPro plasmid, complete sequence	2347-2397	0	1.0

1. spacer 1.1|2347|51|NZ_CP012476|CRISPRCasFinder matches to NZ_CP012476 (Bacillus clausii strain ENTPro plasmid, complete sequence) position: , mismatch: 0, identity: 1.0

aacaacgagaaacaatgaaacgattaatcgccagaacatccagaataacaa	CRISPR spacer
aacaacgagaaacaatgaaacgattaatcgccagaacatccagaataacaa	Protospacer
***************************************************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012475_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_1

415881-415963

Orphan

Consensus_repeat	Method
GCTCCCCATTACTGGGGAGTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012475_1

>merge|NZ_CP012475|1|415881-415963|CRISPRCasFinder
GCTCCCCATTACTGGGGAGTTTTCAGTCTGATGGCGGTTATCGACTTTGTCGACAACCTCGCTCCCCATTACTGGGGGGTTTT

>NZ_CP012475|1|1|415881-415963|CRISPRCasFinder
GCTCCCCATTACTGGGGAGTTTT	CAGTCTGATGGCGGTTATCGACTTTGTCGACAACCTC
GCTCCCCATTACTGGGGGGTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_035204501.1\|420636_422169_-\|L-aspartate-oxidase	unknown	unknown	gnl\|CDD\|236147
NZ_CP012475.1\|WP_011246390.1\|422256_423372_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NZ_CP012475.1\|WP_035204507.1\|415964_416801_-\|YhcN/YlaJ-family-sporulation-lipoprotein	unknown	unknown	gnl\|CDD\|378211
NZ_CP012475.1\|WP_011246387.1\|424823_425267_-\|ACT-domain-containing-protein	unknown	unknown	gnl\|CDD\|179848
NZ_CP012475.1\|WP_035204497.1\|423932_424808_-\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|237013
NZ_CP012475.1\|WP_035204499.1\|423379_423916_+\|transcription-repressor-NadR	unknown	unknown	gnl\|CDD\|224740
NZ_CP012475.1\|WP_035204505.1\|418722_419817_-\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NZ_CP012475.1\|WP_011246399.1\|413077_414079_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NZ_CP012475.1\|WP_011246402.1\|410609_411761_-\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
NZ_CP012475.1\|WP_011246403.1\|410300_410564_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|376903
NZ_CP012475.1\|WP_035204495.1\|425452_426739_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237046
NZ_CP012475.1\|WP_179290691.1\|414824_415346_-\|BofC-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|370208
NZ_CP012475.1\|WP_011246398.1\|414094_414694_-\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NZ_CP012475.1\|WP_035204503.1\|419807_420656_-\|carboxylating-nicotinate-nucleotide-diphosphorylase	unknown	unknown	gnl\|CDD\|181221
NZ_CP012475.1\|WP_035204516.1\|409812_410193_+\|TIGR04086-family-membrane-protein	unknown	unknown	gnl\|CDD\|274969
NZ_CP012475.1\|WP_035204514.1\|411774_412803_-\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl\|CDD\|234666
NZ_CP012475.1\|WP_035204519.1\|409213_409678_-\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NZ_CP012475.1\|WP_011246400.1\|412881_413085_-\|DUF2905-domain-containing-protein	unknown	unknown	gnl\|CDD\|378570
NZ_CP012475.1\|WP_035204510.1\|415495_415870_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|259980
NZ_CP012475.1\|WP_051881219.1\|416879_418409_-\|SafA/ExsA-family-spore-coat-assembly-protein	unknown	unknown	gnl\|CDD\|131945

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_035204501.1\|420636_422169_-\|L-aspartate-oxidase	gnl\|CDD\|236147	PRK08071, PRK08071, L-aspartate oxidase; Provisional.	3.32474e-177
NZ_CP012475.1\|WP_011246390.1\|422256_423372_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	3.30844e-136
NZ_CP012475.1\|WP_035204507.1\|415964_416801_-\|YhcN/YlaJ-family-sporulation-lipoprotein	gnl\|CDD\|378211	pfam09580, Spore_YhcN_YlaJ, Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ). This entry contains YhcN and YlaJ, which are predicted lipoproteins that have been detected as spore proteins but not vegetative proteins in Bacillus subtilis. Both appear to be expressed under control of the RNA polymerase sigma-G factor. The YlaJ-like members of this family have a low-complexity, strongly acidic, 40-residue C-terminal domain.	6.03493e-14
NZ_CP012475.1\|WP_011246387.1\|424823_425267_-\|ACT-domain-containing-protein	gnl\|CDD\|179848	PRK04435, PRK04435, ACT domain-containing protein.	1.44937e-82
NZ_CP012475.1\|WP_035204497.1\|423932_424808_-\|prephenate-dehydratase	gnl\|CDD\|237013	PRK11898, PRK11898, prephenate dehydratase; Provisional.	2.83594e-146
NZ_CP012475.1\|WP_035204499.1\|423379_423916_+\|transcription-repressor-NadR	gnl\|CDD\|224740	COG1827, COG1827, Predicted small molecule binding protein (contains 3H domain) [General function prediction only].	1.12151e-44
NZ_CP012475.1\|WP_035204505.1\|418722_419817_-\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	1.98132e-145
NZ_CP012475.1\|WP_011246399.1\|413077_414079_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NZ_CP012475.1\|WP_011246402.1\|410609_411761_-\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	0
NZ_CP012475.1\|WP_011246403.1\|410300_410564_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|376903	pfam02699, YajC, Preprotein translocase subunit. See.	2.44908e-31
NZ_CP012475.1\|WP_035204495.1\|425452_426739_-\|GTPase-ObgE	gnl\|CDD\|237046	PRK12297, obgE, GTPase CgtA; Reviewed.	0
NZ_CP012475.1\|WP_179290691.1\|414824_415346_-\|BofC-C-terminal-domain-containing-protein	gnl\|CDD\|370208	pfam08955, BofC_C, BofC C-terminal domain. The C-terminal domain of the bacterial protein 'bypass of forespore C' contains a three-stranded beta-sheet and three alpha-helices. Its exact function is, as yet, unknown.	5.50491e-25
NZ_CP012475.1\|WP_011246398.1\|414094_414694_-\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	1.72657e-84
NZ_CP012475.1\|WP_035204503.1\|419807_420656_-\|carboxylating-nicotinate-nucleotide-diphosphorylase	gnl\|CDD\|181221	PRK08072, PRK08072, carboxylating nicotinate-nucleotide diphosphorylase.	9.95824e-171
NZ_CP012475.1\|WP_035204516.1\|409812_410193_+\|TIGR04086-family-membrane-protein	gnl\|CDD\|274969	TIGR04086, hypothetical_protein, putative membrane protein, TIGR04086 family. Members of this family of strongly hydrophobic putative transmembrane protein average about 125 amino acids in length and occur mostly, but not exclusively, in the Firmicutes. Members are quite diverse in sequence. The function is unknown.	4.19575e-18
NZ_CP012475.1\|WP_035204514.1\|411774_412803_-\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0
NZ_CP012475.1\|WP_035204519.1\|409213_409678_-\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	8.64927e-12
NZ_CP012475.1\|WP_011246400.1\|412881_413085_-\|DUF2905-domain-containing-protein	gnl\|CDD\|378570	pfam11146, DUF2905, Protein of unknown function (DUF2905). This is a family of bacterial proteins conserved of unknown function.	1.9819e-15
NZ_CP012475.1\|WP_035204510.1\|415495_415870_+\|hypothetical-protein	gnl\|CDD\|259980	cd13913, ba3_CcO_II_C, C-terminal cupredoxin domain of Ba3-like heme-copper oxidase subunit II. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea, which catalyze the reduction of O2 and simultaneously pump protons across the membrane. It has been proposed that archaea acquired heme-copper oxidases through gene transfer from gram-positive bacteria. The ba3 family contains oxidases that lack the conserved residues that form the D- and K-pathways in CcO and ubiquinol oxidase. Instead, they contain a potential alternative K-pathway. Additional proton channels have been proposed for this family of oxidases but none have been identified definitively.	5.4326e-08
NZ_CP012475.1\|WP_051881219.1\|416879_418409_-\|SafA/ExsA-family-spore-coat-assembly-protein	gnl\|CDD\|131945	TIGR02899, hypothetical_conserved_protein, spore coat assembly protein SafA. SafA (YrbB) (SafA) of Bacillus subtilis is a protein found at the interface of the spore cortex and spore coat, and is dependent on SpoVID for its localization. This model is based on the N-terminal LysM (lysin motif) domain (see pfamAM model pfam01476) of SafA and, from several other spore-forming species, the protein with the most similar N-terminal region. However, this set of proteins differs greatly in C-terminal of the LysM domaim; blocks of 12-residue and 13-residue repeats are found in the Bacillus cereus group, tandem LysM domains in Thermoanaerobacter tengcongensis MB4, etc. in which one of which is found in most examples of endospore-forming bacteria. [Cellular processes, Sporulation and germination].	2.11611e-13

>NZ_CP012475.1|WP_035204510.1|415495_415870_+|hypothetical-protein
MRKLAGVVTACLLFFILTACGAQEDSGQEDNSTAESSETVVIKAMNWQFDKEEYAAGAGDVTVELKNEEGNHGIIIVGADNGSDLVISGSDSKTVTLEPGEYEIQCNIPCGPGHEEMVSTLIVS
>NZ_CP012475.1|WP_179290691.1|414824_415346_-|BofC-C-terminal-domain-containing-protein
MMLKQVVHKHWLPFSLGAASFALLLGTFIILGEDASNDSPQVANPPNATEVLRETVFADGNIRTERVEETIWAIDDFWAEYEEWQLVDQSNHFVHFRKTILDLSPEVKEDGYLGIDADRGIVLYTGAQEAGQIVTRYSEIEAAKLSESDVAALEQGIRIESLEHLQNLLAQWR
>NZ_CP012475.1|WP_011246398.1|414094_414694_-|Holliday-junction-branch-migration-protein-RuvA
MIDYIKGNLVAVEPAYLVVEANGIGFQIYCANPYRFINDLNREVVVPTHHYVREDSQRLFGFTTRTERLLFEKLLNVSGIGPKGALAILASGEPEDIIHAIEQEDEALLVRFPGVGKKTARQIILDLKGKLDDMAPMLEPAAGADKQQKNPQLEDALEALRALGYVEKELKKVEKQLKAETLETDEYIRRALALMLKRP
>NZ_CP012475.1|WP_011246399.1|413077_414079_-|Holliday-junction-branch-migration-DNA-helicase-RuvB
MEERIVSAEATELEEQSEQGLRPKRLADYIGQETVKHNLAVFMEAAKMREEALDHVLLYGPPGLGKTTLAAIIAAEMGGELRTTSGPAIERSGDLAAILTALEPGDVLFIDEIHRLNRTVEEVLYPAMEDFCLDIVIGKGPTARSVRLDLPPFTLVGATTRAGMLSSPLRDRFGVMARLEYYKPEELAQIVERSATVFQATLEPSAALELARRSRGTPRIANRLLRRVRDFAQVGGEAAISLERACSALEQLHVDPLGLDHIDDKLLKGMIEKFNGGPVGLETIAATIGEEAATIEEVYEPYLLQIGFIQRTPRGRIATPACYAHYGVEKQNG
>NZ_CP012475.1|WP_011246400.1|412881_413085_-|DUF2905-domain-containing-protein
MGKTLMVIGAVLLIVGFLWQVLGRFLPIGKLPGDFLFKSGQTTVYFPIMTCIIISIVLSLLFSLFRR
>NZ_CP012475.1|WP_035204514.1|411774_412803_-|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MDVNEFDFDLPEELIAQTPLKTRTNSRLLVVDKKTKAISDRMFPDLIEALSPGDCLVLNDTKVMPARLLGEKVETKAVIELLLLKQLEGDCWETLVKPAKRVKIGTEVSFGDGKLTAICTAVQPQGGRIFEFRYSGVFYELLEELGTMPLPPYIKERLEDADRYQTVYAKQIGSAAAPTAGLHFSEQLLSEIEAKGVKIVYITLHVGLGTFRPVSASSVEDHQMHAEYYQVTEEAAHTLASARENGGNIIAVGTTSARTLETIYSDHGAFVAASGWTSIFIYPGYKYQAIDGLLTNFHLPKSTLVMLVSALIGKEALMDAYAHAIKERYRFFSFGDAMFIRP
>NZ_CP012475.1|WP_011246402.1|410609_411761_-|tRNA-guanosine(34)-transglycosylase-Tgt
MTAAITYEHIKTCKQSGARLGRVHTPHGTIETPMFMPVGTLATVKTMSPEDLKAMDAQIILSNTYHLWLRPGEEIIKEAGGLHQFMNWDKPILTDSGGFQVFSLSDLRKITEEGVHFRNHLSGEKLFLSPEKAMQIQHVLGSDIMMAFDECPPYPADHSYMKASVERTSRWAERCLAEHKRSGKDSVQGLFGIIQGGEYEDLRKQSANDLTALDFPGYAVGGLSVGEPKDVMNHVLEFTTPLMPEDKPRYLMGVGSPDSLIDGAIRGIDMFDCVLPTRIARNGTCMTSAGRLVVRNAKYARDFSPLDEKCDCHVCRTYSRAYIRHLIKCEETFGFRLTTYHNLYFLLNLMKQVRQAIMDDCLLDFREQFFEEYGFNKENARNF
>NZ_CP012475.1|WP_011246403.1|410300_410564_-|preprotein-translocase-subunit-YajC
MELLVSMLPFIAIIVLFYFLLIRPQQKQQKRVREMHANLQRGDKVITIGGLHGVIDSIDESVVVLLVNDNRKLTYDRNAIREVVQSD
>NZ_CP012475.1|WP_035204516.1|409812_410193_+|TIGR04086-family-membrane-protein
MESRRFFPAVCIGTFVSICIAVAFSILMATLLYLTSLTEQSVHWVMVGCGFLALFVGGFFSGAKAKNKGWLAGAFTAFLFVAILLAISYLGYNESITSNQVLLFAGYCAIASLGGVFGVNFSGGNS
>NZ_CP012475.1|WP_035204519.1|409213_409678_-|DUF421-domain-containing-protein
MDAMIVRAAATYAALVLIKQYKNETTQTQQGPFELALALFAGEAIATFWSLWVLLPIFLLVIAAILKRKTGESGKLQHTSKPPTVAPPLQKEGPALAMPLPLIIDGTIQHDHLRELRQTELWLRQQLRKLGYRDIKKIAYCSLKGKESFFIDSF
>NZ_CP012475.1|WP_035204507.1|415964_416801_-|YhcN/YlaJ-family-sporulation-lipoprotein
MKKTALSFICASVLLTGLAGCGTQDNNRAGMQPNTYRNQEANLNGDNNFNNRNYPYYGPNAYNTNDKTFFDDNRFSNKNQRMNRTNQYNQGRNGYVRGITGNNRPGMVDENGFLNRRADYGNRGMNFQRATTNKDGNRGINAQRSTNQDGNMRQGMETEEVRYHRNYDGDRVEEIREEVEKIDGVREARVIINRDDVVVGYEQDEKADDVKQHVENRVRKLAGKGKNVVVSTDNNIYKNMRKMDDKLRSGAAFDDVRDTFTDMMRDLGNAAKRPFQNK
>NZ_CP012475.1|WP_051881219.1|416879_418409_-|SafA/ExsA-family-spore-coat-assembly-protein
MRIHIVQKGDTLWKLAEKYEVDYEHLKEANPNLTNPEMLMPGMKVKVPAGSVAVRKEQKKTTPKAKEVDKKQQKAKEQSVKPPKKPELKASEKTQAANVAPAPPYYGQTQQGVAKPPEYPPLPPKPPCTPCQGNAFQEFAPQANMYQQSYAPNQQLYSQQMNQPPSYQPQANQPQSYPPQSYQPQANQPQSYQPQLYQPQANQPQSYQPQSYQPQANQPQSYQPQSYQPQANQPQSYQPQIFQPQAYGENAQLQAQSHGPKQQESAGKHQPLPQDKKDNEAGEWNGVQPQAHKGSSKSGIHGQQSPWGSNAPFVQQSGGPNQQSYPIQENQNKGFQGQQNTNFTPWPQQENKGWNQEQAYAHQVEMNWGQSNGAQPFSQQMDINWGQYRYSPYQGEIGDAAPFQSYPGWQPAALPQMPVANSYPPPQTPFFAPGTLNQQAGPYRQPPVGQLDDQLYQQPHYMNQAPSFLTGPYAAQPQQWAHPQSPYLQEQEYEPEEQINAYEEEDQQD
>NZ_CP012475.1|WP_035204505.1|418722_419817_-|quinolinate-synthase-NadA
MQVMQPARLPHHYREMSSAEKEARIREAKAFFGNDLLIPGHHYQREDVIQFADFTGDSLQLAQLCGQTSSANIVFCGVHFMAETADMLTSREQHVILPDLAAGCSMADMASIAQTERAWVALTERFGDTILPLTYVNSTAEIKAFCGRHGGACVTSSNAKNMVQWAFAQKPRVMFLPDQHLGRNTAFALGIPLEKMAVWNPHTHELELPPGANIEEIIVILWKGHCSVHEKFTVEQIKNVRDRSPHTQVIVHPECTHEVVQAADKAGSTHYIIETLKQAEPGTSWAIGTEMNLVNRLAKQHPDKQVFSLHSTMCLCLTMNRIDLDHLAWSLDLLREGKRQFEITVAEDVAEEARTALARMLATV
>NZ_CP012475.1|WP_035204503.1|419807_420656_-|carboxylating-nicotinate-nucleotide-diphosphorylase
MNPLKLDQQLRGFLAEDIGYGDRTAEALFTVERAEAVIVAKGEGIFAGTQVVNQLYALLDSDIEVELFVCDGEQVKRGQQLARFTGPVKSLLSGERVLLNLLQRMCGIATLTAKAVEELGDPSIRVCDTRKTAPGLRMFDKFAVRIGGGANHRFGLDDALMLKENHIAACTSIAAAIEKARAYAGPMAKIEVETTTLDEVKEAVAAQADVIMFDNATPEAIRTYLAYVPAGIKTEASGGITMANLRQFANTGVDFLSLGFLTHSVVALDLSMLIQKGEEQCK
>NZ_CP012475.1|WP_035204501.1|420636_422169_-|L-aspartate-oxidase
MKKKSVIIVGAGIAGLMAAHKLADKAEVSLLMKAGRLDSNSCMAQGGIAAAVGETDHPTLHARDTFVAGSGFNAFKRASELARQAPAMIKELDALGVPFEKAAGQYVLGHEAAHSKRRILHAYQDQTGLAVVETLWRTLSENVHVYENQYVLELIVKNQTIQGVRTVNHAFYGDCVVIATGGSGQLYENSSNEQRATGDGLMLAYRAGAVLKDLEFMQFHPTILKGKEPSLISEAVRGEGAYLVNRAGHRLMGKWAKGELEGRDVVAATLHKALQSGENVYLDARHLHDFPSRFPAIYRRLQRNGYDVRKDLIPIEPGAHFLCGGIETDRFGRTSVNGLYAIGEAACTGVHGANRLASNSLVEALVYGQAVAAALLADPQTKAGAVKPQPNKALIHGIPERSELQKMMSAYAGIERDAYRLQTVANWLSSFQQMPKKTVVHVDDLETGTMYELATLVVKAALLRTETRGTHRRSDYPSADEQWRKRSICFSVQNKAFVKTEEREYEPAQA
>NZ_CP012475.1|WP_011246390.1|422256_423372_+|cysteine-desulfurase
MYYLDYSATTPLSPLCLDVYQKTAQLAFANSNSLHTFGLEARAILEQARTKFASLLRLTEEELYFTGSGSESNFLAIVSLAFAYRNKGQHLVSTKTEHPSVLEALHYLEKHGYEITYVPVTEEGNVTVEALRASLRPDTVLASIAVASSEIGTVQDIAHLSNVLRSRGILFHSDCVQALGKIEIDFSLLDAASFSAHKLYAPKGTGAVYLSKRLHWRGFYEQARHESGFRPGTVDTPAVAAFASAVEHALSIRKTRMAELAELRDTIIRQLTATGHFQLVGSKKERLPFHIGMLVKGWSGQQFMLECDRAGFAIATGSACQAGQTSPPLSLLALGLTNEQADRYVRVTLGEPTTEDEVGMFIEHCTKIVCR
>NZ_CP012475.1|WP_035204499.1|423379_423916_+|transcription-repressor-NadR
MRKEKKLKSEERRAAIVEWLKKENAPLKGSDLAKRAGVSRQVVVQDMSLLKAKGEPIFATAQGYMYLAPATKQKVQRLIAVQHRPEDTREELYTFVDHGLTVINVSIEHAIYGELTGAMHISNRQEVDAFCATLAKTKASLLSELTEGVHLHLVEGQNEAQVEKAIAALREKSFLLEE
>NZ_CP012475.1|WP_035204497.1|423932_424808_-|prephenate-dehydratase
MKKVGFLGPKGTFTEMAAYSLFPKEELVPLKTIPKVLDLAFAKGIDYAVVPIENAIEGTVNITLDYLIHHKPMPIVASISLEIAQHLLFSPNKDRETFVPKKVVSHPQAIAQCHQFLQKNYPEIEIEYADSTGSAAAWLAENPDADACVIANAQAASTYGLAVAQGDIHDFEHNRTRFIVLTAKKEQAPHIVGPEHTGDKTTLMVTLPSDFAGALHQVLSAFAWRKLNLSKIESRPTKTGLGNYFFLIDIDQLMDDVLVPGAIAELTALGCKVEVLGSYATYSSKATASIN
>NZ_CP012475.1|WP_011246387.1|424823_425267_-|ACT-domain-containing-protein
MSKKQFYLVREDMLTDAMQRTLEAKALLSAGKVRKINEAVHRVGLSRSAFYKYKDGIFPFHAIAKERIMTFSINLADRSGTLSQLLNIVADTGANILTINQTIPLQGRANITLSVDTAPIEIDINELFERMEALESVERVELVGSGS
>NZ_CP012475.1|WP_035204495.1|425452_426739_-|GTPase-ObgE
MFVDKVKVYAKGGDGGNGMVAYRREKYVPDGGPAGGDGGRGASVILEVDEGLRTLMDFRYNKHFKGKRGEHGMSKNMHGKKAEDLVVKVPPGTMVTDEETGALLADLTTHGQRAVVAKGGRGGRGNVRFATPANPAPDHAENGEPGEERNLLLELKVLADVGLVGFPSVGKSTLLSIVSAAKPKIAEYHFTTITPNLGVVDAQDGRSFVMADLPGLIEGAHEGVGLGHQFLRHIERTRVIVHIVDMSAMEGRDPVEDYHKINEELSQYNYRLTERPQLVVANKMDMPEANENLKRFKEALGEETKIFPVSAITKDGVRELMLAIADELEHAPEFPLHDSEEQVEGRVLYKHELPIEPFTITRGDDGVFELSGAELERAFKMTDFAREESVRRFARRMRKMGVDEALRKRGAKDGDLVRIMKFEFEFVE

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Crispr_ID: NZ_CP012475_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_2

2500202-2500565

Orphan

I-C

Consensus_repeat	Method
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	PILER-CR
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	CRT

5 spacers

The CRISPR arrays of NZ_CP012475_2

>merge|NZ_CP012475|2|2500202-2500565|PILER-CR,CRISPRCasFinder,CRT
GTCGCACTCTATGTGAGTGCGTGGATTGAAATATGTCAGACATGGCCTGATTGGCAAGCGTATATCGTCGCACTCTATGTGAGTGCGTGGATTGAAATTTTGGGCTCCTAATAACGTTTTATACATATTCTCACGTCGCACTCTATGTGAGTGCGTGGATTGAAATGATCATCGTTTCCCCTCCTATCTATAATCCGCAGTCGCACTCTATGTGAGTGCGTGGATTGAAATTGAAATTGCGCCCTCCTGCGTAAACAGTGGGGCAAGTCGCACTCTTTGTGAGTGCGTGGATTGAAATCCCATAATCGTGTCTTTAGCATCGCCATATAGTGGTCGCACTCTATGCGAGTGCGTCGATTGAATC

>NZ_CP012475|2|1|2500202-2500499|PILER-CR
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	ATGTCAGACATGGCCTGATTGGCAAGCGTATATC
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	TTTGGGCTCCTAATAACGTTTTATACATATTCTCAC
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	GATCATCGTTTCCCCTCCTATCTATAATCCGCA
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	TGAAATTGCGCCCTCCTGCGTAAACAGTGGGGCAA
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT

>NZ_CP012475|2|2|2500202-2500565|CRISPRCasFinder
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	ATGTCAGACATGGCCTGATTGGCAAGCGTATATC
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	TTTGGGCTCCTAATAACGTTTTATACATATTCTCAC
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	GATCATCGTTTCCCCTCCTATCTATAATCCGCA
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	TGAAATTGCGCCCTCCTGCGTAAACAGTGGGGCAA
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CCCATAATCGTGTCTTTAGCATCGCCATATAGTG
GTCGCACTCTATGCGAGTGCGTCGATTGAATC

>NZ_CP012475|2|1|2500202-2500565|CRT
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	ATGTCAGACATGGCCTGATTGGCAAGCGTATATC
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	TTTGGGCTCCTAATAACGTTTTATACATATTCTCAC
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	GATCATCGTTTCCCCTCCTATCTATAATCCGCA
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	TGAAATTGCGCCCTCCTGCGTAAACAGTGGGGCAA
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CCCATAATCGTGTCTTTAGCATCGCCATATAGTG
GTCGCACTCTATGCGAGTGCGTCGATTGAATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_051881135.1\|2502397_2503978_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173863
NZ_CP012475.1\|WP_035202483.1\|2502101_2502344_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035202497.1\|2490315_2491824_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225962
NZ_CP012475.1\|WP_011248511.1\|2491823_2492315_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225937
NZ_CP012475.1\|WP_011248497.1\|2504977_2505901_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP012475.1\|WP_011248495.1\|2506933_2507968_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|185037
NZ_CP012475.1\|WP_035202486.1\|2499020_2499917_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225518
NZ_CP012475.1\|WP_011248505.1\|2495801_2497070_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NZ_CP012475.1\|WP_035202484.1\|2500795_2501671_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP012475.1\|WP_035202489.1\|2497930_2499016_+\|DUF871-domain-containing-protein	unknown	unknown	gnl\|CDD\|377567
NZ_CP012475.1\|WP_011248506.1\|2495437_2495743_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035202495.1\|2492585_2493401_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP012475.1\|WP_011248496.1\|2505944_2506937_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP012475.1\|WP_011248504.1\|2497094_2497403_-\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99906
NZ_CP012475.1\|WP_035202479.1\|2508018_2509230_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349891
NZ_CP012475.1\|WP_035202478.1\|2509287_2510655_+\|anion-permease	unknown	unknown	gnl\|CDD\|273267
NZ_CP012475.1\|WP_051881134.1\|2510796_2511990_+\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349883
NZ_CP012475.1\|WP_035202492.1\|2494128_2495445_-\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|133432
NZ_CP012475.1\|WP_035202481.1\|2504048_2504966_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP012475.1\|WP_011248503.1\|2497589_2497928_+\|PTS-lactose/cellobiose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|376749

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_051881135.1\|2502397_2503978_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173863	cd08498, PBP2_NikA_DppA_OppA_like_2, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP012475.1\|WP_035202481.1\|2504048_2504966_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.98814e-123
NZ_CP012475.1\|WP_035202497.1\|2490315_2491824_-\|PH-domain-containing-protein	gnl\|CDD\|225962	COG3428, COG3428, Predicted membrane protein [Function unknown].	7.80234e-47
NZ_CP012475.1\|WP_011248511.1\|2491823_2492315_-\|PH-domain-containing-protein	gnl\|CDD\|225937	COG3402, COG3402, Uncharacterized conserved protein [Function unknown].	6.46504e-28
NZ_CP012475.1\|WP_011248497.1\|2504977_2505901_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.00257e-105
NZ_CP012475.1\|WP_011248495.1\|2506933_2507968_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|185037	PRK15079, PRK15079, oligopeptide ABC transporter ATP-binding protein OppF; Provisional.	2.10518e-150
NZ_CP012475.1\|WP_035202486.1\|2499020_2499917_+\|hypothetical-protein	gnl\|CDD\|225518	COG2971, COG2971, Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism].	1.20392e-33
NZ_CP012475.1\|WP_011248505.1\|2495801_2497070_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	1.01631e-147
NZ_CP012475.1\|WP_035202484.1\|2500795_2501671_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.63152e-51
NZ_CP012475.1\|WP_035202489.1\|2497930_2499016_+\|DUF871-domain-containing-protein	gnl\|CDD\|377567	pfam05913, DUF871, Bacterial protein of unknown function (DUF871). This family consists of several conserved hypothetical proteins from bacteria and archaea. The function of this family is unknown.	0
NZ_CP012475.1\|WP_035202495.1\|2492585_2493401_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	8.86419e-11
NZ_CP012475.1\|WP_011248496.1\|2505944_2506937_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	0
NZ_CP012475.1\|WP_011248504.1\|2497094_2497403_-\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99906	cd05564, PTS_IIB_chitobiose_lichenan, PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	6.07087e-37
NZ_CP012475.1\|WP_035202479.1\|2508018_2509230_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349891	cd03896, M20_PAAh_like, M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins. Peptidase M20 family, Poly(aspartic acid) hydrolase (PAA hydrolase)-like subfamily. PAA hydrolase enzymes are involved in alpha,beta-poly(D,L-aspartic acid) (tPAA) biodegradation. PAA is being extensively studied as a replacement for commercial polycarboxylate components since it can be degraded by enzymes from isolated tPAA degrading bacteria. Thus far, two types of PAA degrading bacteria (Sphingomonas sp. KT-1 and Pedobacter sp. KP-2) have been investigated in detail; the former can completely degrade tPAA of low-molecular weights below 5000, while the latter can degrade high molecular weight tPAA to release oligo(aspartic acid) (OAA) as a product, suggesting two kinds of PAA degrading enzymes. It has been shown that PAA hydrolase-1 from Sphingomonas sp. KT-1 hydrolyzes beta,beta-aspartic acid units in tPAA to produce OAA, and it is suggested that PAA hydrolase-2 hydrolyzes OAA to aspartic acid. Also included in this family is Bradyrhizobium 5-nitroanthranilic acid (5NAA)-aminohydrolase (5NAA-A), a biodegradation enzyme that converts 5NAA to 5-nitrosalicylic acid; 5NAA is a metabolite secreted by Streptomyces scabies, the bacterium responsible for potato scab, and metabolized by Bradyrhizobium species strain JS329.	1.82982e-94
NZ_CP012475.1\|WP_035202478.1\|2509287_2510655_+\|anion-permease	gnl\|CDD\|273267	TIGR00785, Uncharacterized_transporter_HI_0020, anion transporter. The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds].	3.26241e-42
NZ_CP012475.1\|WP_051881134.1\|2510796_2511990_+\|M20-family-metallopeptidase	gnl\|CDD\|349883	cd03887, M20_Acy1L2, M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family. Peptidase M20 family, Aminoacylase 1-like protein 2 (ACY1L2; amidohydrolase) subfamily. This group contains many uncharacterized proteins predicted as amidohydrolases, including gene products of abgA and abgB that catalyze the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia coli, to p-aminobenzoate and glutamate. p-Aminobenzoyl-glutamate utilization is catalyzed by the abg region gene product, AbgT. Aminoacylase 1 (ACY1) proteins are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	4.47824e-158
NZ_CP012475.1\|WP_035202492.1\|2494128_2495445_-\|6-phospho-beta-glucosidase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CP012475.1\|WP_011248503.1\|2497589_2497928_+\|PTS-lactose/cellobiose-transporter-subunit-IIA	gnl\|CDD\|376749	pfam02255, PTS_IIA, PTS system, Lactose/Cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.	3.0484e-35

>NZ_CP012475.1|WP_035202486.1|2499020_2499917_+|hypothetical-protein
MYVIGLDAGGTKTHGAVIDQEQNIHFSIETGPGNVAVDSEKAKEHIMAAIQACIQSKYGSLCKAIVLGIAGIEKGHLKSEFKTLVEQHFQLPALMLNDAELALYAVLEDENGVLAIAGTGSVLIGKKDATIKMVGGWGHLLGDEGSAYHIGIQALKQLASEIEQGTIQTKLAKALATQYQLPDASAVKEFVYSSTKKEIADIALFVYRRAQDDTDAKKLLEQAGEELAQQAIRLVKQLELETSSIPIIVKGSLLEKNEFVRHHFAEKLKQCSADISIVCKNRPAVTGALHAWKISSHH
>NZ_CP012475.1|WP_035202489.1|2497930_2499016_+|DUF871-domain-containing-protein
MQQLGISIYPNHSTAEKDKQYIHVANQYGFTRVFTCLLSVEQDNILASFQETIHYAKQLGMEVICDINPRVFKDLGISYDDLTFFKNLGADGIRLDLGFTGNEESMMTFNPHGLFIEVNMSNSTKYIDNILSFQPNRNKLIGCHNFYPHRYSGLSYDFFIECSEKFKKYGLRTAAFVSSQAASFGPWPIVEGLPTLEMHRGLPIDVQAKHLFATRLIDDVIIGNAYASEEELKRLSQINKAKLTFNLELVDSVSDLEKKILFDEPHFYRGDVSDYMIRSTQSRVKYRGEAFPPHNTTDIKRGDVVIESELYEQYAGELQIALKDMTNSGRTNVIARIREEEIFLIDSLKPWDKFAFSEWDG
>NZ_CP012475.1|WP_011248503.1|2497589_2497928_+|PTS-lactose/cellobiose-transporter-subunit-IIA
MNVEVEIFNMISNAGDAKSIAYEALKLAQNNDFHLANEKLETANKTLAKAHNTQTKLIQAEINGEHVEQSLLMVHAQDHLMAAISEMSLIEQMIAILRRVAQLEARSESESV
>NZ_CP012475.1|WP_011248504.1|2497094_2497403_-|PTS-sugar-transporter-subunit-IIB
MTKVLFVCSGGMSSAIVVNTLKKEAEKHGQALEVKAIGSSEVAAELENNWDVVMVAPQIKHRFDNIKKEADAYGVPCGPIPPQAYTPLGGPTLLKTLQELVK
>NZ_CP012475.1|WP_011248505.1|2495801_2497070_-|PTS-sugar-transporter-subunit-IIC
MGKFIDFLEKRVSNPMARLAEQRHLLAVRDGVVSSLPFIIVGSFFLIIAFPPLPESWGMTQWATENADQILIPYRMTMFIMSLYVAFGIGYNLAQSYKVDPLSGGQIAVASLLLTITPSVVEELGFVLPMQYLGGSGLFVTIIVSILSVEIFRICKQRNITIRLPEAVPASVSRSFEALIPVAIVIMLMTLITIIMGVNLHALVEKLTVPLVTAGDSLFGVLVPVFLITFFWSFGIHGVSVVGSVARPLWETYLLKNGEAVASGASELPHIAPEPLYQWFIWIGGSGATLGLVIVMLIFARSKYLKSLGRTVAVPSIFNINEPVIFGLPIVLNPILVIPFIITPIITAVIAYLATSVGLVSPTFIKAPWTLPAPIGAYLATGGDWRSIILVLVNLAISVVIYLPFLRIYDKKMLAMEQNEEQ
>NZ_CP012475.1|WP_011248506.1|2495437_2495743_-|hypothetical-protein
MEQSRLIPRISPKGVFVFMMILFFGMLLLSIPLKYIHLSETMSAFLSAGISAAIGIGIVLTKIDGKTTDKRLNRQRIRIAIIVGFATSALMTFVFGGDLLG
>NZ_CP012475.1|WP_035202492.1|2494128_2495445_-|6-phospho-beta-glucosidase
MGKKGIKIVTIGGGSSYTPEFVEGLIKRHKELPVRELWLVDIEKGKEKLEIVGNLAKRMVKKAGLPITIYTTFDRKEALKDADFVTTQMRVGLLEARIKDERIPLKHGMIGQETNGAGGLFKALRTIPVLLEIAEQMHELCPNAWLINFTNPAGIVTEAVMKYSQHKKIIGVCNVPINTKMTIATLLDVPPDQLTITFAGLNHMSYGLDVHVNGESRLNDVIDLVTDPDHEVTMKNIIPLPWEKAFMKALGCIPSPYHRYYYKTNEILQKELEEFKQGKTRAEVVKQLEDELFELYKDPDLDIKPPQLEKRGGAYYSDAACNLISSIYNDKGDVQTLNTRNEGAITNLPNDTVVEVNCIVTKQGPIPLAIGELPYSINGLIQQIKSFELVAIEAAVTGSYEQALLALCINPLITSDVKAKEILDEMLEAHKTDLPQFQ
>NZ_CP012475.1|WP_035202495.1|2492585_2493401_-|CPBP-family-intramembrane-metalloprotease
MKKLTSTILKTIIFFMSWAILISFTPDIHTNSQAYLRLWWEFTPLVVVVLLSVVFVFIVEKGKITIPVAPRFLKSSLIGMVLGVLWLGSVVTVFLLTKTMNIQGQNSVDYIWIWILASLLNVAMQELLVRGYLYQLWKQKYNVIVATILTTILFTVMHGGAFEAGMIPVINVISMSIFVTLLLEYTGTIVAPIIIHFIWNTVGAIILGGVSLAGDYPNLLINTFQGSLLISGGTYKFEGSIIVSIANLILITSLLVLNKRKRNDNLSGLLK
>NZ_CP012475.1|WP_011248511.1|2491823_2492315_-|PH-domain-containing-protein
MSIPINAPQKRLSKDAIKVWLISDAIGNMIVLIILGILFYLDDRFLWKEWVGWLLIGATVLTIIGWIWSVIRPFLLYKHWRYDVDEAYLQLKSGALKETHELVPMTKIQSVATEQGPLLRKYGLCSVSVETMGSSHTIPALPKEAAVELRNQIAQYARIKEVE
>NZ_CP012475.1|WP_035202497.1|2490315_2491824_-|PH-domain-containing-protein
MTKAKRYSPYTMLFHLINLVRNAFFFVIYLYVVMAGSESAFIKYGRMAFWIIVGLILFSIIYKWVTHKYKLDEQSFHLYKGLFSKTEQTIPFSKIENINRHTSFLHRVFKRTSIHFEIAMTGENAHIKFEVLSKAEAEQIEAHIKRATDEELDGWNHPSHDPNDEEAHPRDPAQERTIHFQPTKRDILKASVTSLSFLVLIPLIGSFYFKINDLFHVEDTTEGLINKLASSWWIVAIIIIVLIIASTIFGLIRTYVKYGKYEIASDATHIYINRGVIDETAFSISKDKVQAIEIEQSMVKRLLGLAEVKLTSAGGLRSGEEALEKNTLYPFLPVNKAYEMISDMLPSYTITTEMTRLPTKSLWLRILRPSWFWLLATGALFYFKPAIFNIEQSWIIVSAALLVYLLIARLFDFFHTRYAINDHFIQFKTGAFTTSLFVSKREKVIKAKITRNILQKRLGLASIETTNRGNPVRHSGINDVPVELAHSFLQWYRGRKNDITVE
>NZ_CP012475.1|WP_035202484.1|2500795_2501671_-|LysR-family-transcriptional-regulator
MNEKDWELLQTLYEMKNITKAAEKLFISQPALTYRLRSLENEFGVEIAKRGTKRLQFTSEGEYLVEYSRKMLNELAKTKDQLLNMAGNIQGHLRIGVSSHFAHYRLPTILKDFLAVYPNVQVNVTTGWSTKISQKLERKEVHIGIIRGSYEWKEQSILLNEENVCLISKNKIHMGDLPSIGRISYKTDPIFDNMIKDWWNHHFSQPPMVTMEVDRIETCKEMVRNGLGYAIIPQISLRPHDQLYNRILAIDNHPLLRKTWLIYSNSALDLSVVKAFVQFVTTQLRQKAHSL
>NZ_CP012475.1|WP_035202483.1|2502101_2502344_+|hypothetical-protein
MNAKTHASEVRMGKNIAYFWKIYSSFLIGGVLLELKGEEILKKKDRCIPNNVDGQVKDNNGWNVLFLKLRNTGRGSGIGD
>NZ_CP012475.1|WP_051881135.1|2502397_2503978_+|ABC-transporter-substrate-binding-protein
MKRPFLMQMMPIVVGGLLLSGCMTNEENMTTAPDAGGEGGASSSNDTTLTIAQGSDMVSFDVHDHSNTSTEAIHVNMFSYLVKNDVEGEGIVPDLATDWELVDDETWQFTLRDDAVFHNGDPVTAEDVKFTLERVAKDNTLQEHENYRQINEVEVIDDHTFLIHTNGPQPVMLNRLSRLGSGILPKDYIEENGWDHFLQEPVGSGPYQFVEWVRDDRVVLERFDDYFGGDVAVWDQLVFRSIPESSTRVGEVIAGGVDIAMNIAPIDWNRVNENEGTSIVEGQTNRTMMLVPNHREEYPTSDPLVREAIDLAIDNQALLDNLMGGSGTPTLTRVNPGNFGANEALHGEYRYDPDRAKELLEEAGYGDGLELTLHSPDGRYLQDRETTEVIAGMLSEIGIDVKIDFMEWSAYVDLRDAHEQKDLYLIGLTGSLWDAAHQLRHHTSMVAEDHIGYSNEEFDQIYLEAEVNMDEAEREQQYIDLQTMADEELINIMLFQLDSFYAVNDRIQFEPRLDEMWRVEEITLSE
>NZ_CP012475.1|WP_035202481.1|2504048_2504966_+|ABC-transporter-permease
MRKYLLWRVLQIIPVLFLISIFVFALLYLAGDPVALMLPEDATQEQVDALRESLGLDQPFYIQYLSFVGDVIQGDFGYSYRYSQPALPIVLERLPATFELAFASMIVAVLIAVPLGILSATKRNTALDVFISGASVLGKAMPNFWLGIMLILMLAITYPFFPVSGSGSMAHLILPAITLGTGCAAEMTRVLRSSMLETLNQDYVRTAVSKGVKNFFVVYKHAFRNALIPFITITFLQVSTLVSGALITEVVFSWPGLGQLLIQAINGRDMAVVQATVFIVAFIVIVVNLMADVLYRVLDPRIQFD
>NZ_CP012475.1|WP_011248497.1|2504977_2505901_+|ABC-transporter-permease
MQTEQPVKHLRNHTTENRLANWTRRWARLLFKSKTGTIGLIITGLIFLLAIFAPVLSPYHPNVQNYAAMNVPPVWLEGGMKEHLLGTDNLGRDMLSRIIYGTQVSLLVGVCSVVVAGAIGMFFGLIAGYYGGFIDNVLMRIVDAFLAIPNVLFILVILGVLSPGLLTLIFVIGLTNWVIYARLVRGDVLSIKEREFIKAARTIGTKNPVIICKHVLPNVMPSFIVISTLSVATTIVLEASLSYLGLGVQPPTVSWGGMLSAGRDYLATSWWIATFPGLAIMITVLGIIFLGDWLRDVLDPRSQTLRS
>NZ_CP012475.1|WP_011248496.1|2505944_2506937_+|ABC-transporter-ATP-binding-protein
MARQNRLLEVENLKTYFHTENGTVPSVDGVSFHVDRGETVAIVGESGSGKSVTSFSIMGLVSPPGKIEAGHIRFDGTELTSLSERKMRKVRGNEIAMIFQEPLTSLNPVFTVGHQISEAILLHQDTKKAEARKQGIAMLKRVGIPRAEQVYQSYPHALSGGMRQRVMIAMALSCNPKMLIADEPTTALDVTIQAQILRLLKKISKEVDTSIILITHDLGVVAELVDRVIVMYAGQIVEQADVYTIFKDPKHPYTQGLLESTPKIHELHDELKSIRGVVPVPTNMPTGCRFHPRCPHAMDICKEKEPMMVDRDGKAQVRCWLYASEKEDVG
>NZ_CP012475.1|WP_011248495.1|2506933_2507968_+|ATP-binding-cassette-domain-containing-protein
MIKEVANTKEDDTLLEIKGLKKHFDVTRKIFAKKKDILKAVDGVDFIVKKGETFGIVGESGCGKSTTGNMIMRLADPTAGSIHFEGKDLSKLAKNEQSKMKKDIQMIFQDPFSSLNPRMRVFEIIAEPLRTHKIATGKELKQQVYELLDVVGLDRSLAKRFPHEFSGGQRQRIGIARALALRPKLIVCDEPVSALDVSIQSQVLNLLSKLQKDFDLTYIFIAHGLPVVKHISDRVAVMYLGKIVETAATEELFKHPKHPYTEGLLRAIPVPDPTLRSLDSGELLEGDLPSPVNPPSGCHFRTRCPYANEKCKAEAPKLQEVAKAHYVACHYPLQAGRGVIMEHA
>NZ_CP012475.1|WP_035202479.1|2508018_2509230_+|M20/M25/M40-family-metallo-hydrolase
MQQTYEALKNDPAIQQGLAFIEEDDEQTLAEQVAMTEIPAPPFKEAERAAYVQQKFSEYGLEAVRRDKEGNVIGAYKGVGDGPVIVLSAHLDTVFPEGTDTKVRRERDRLCAPGIFDDTRGLAEMLSIIRALHRTNVKTSGTIQFVASVGEEGIGDLRGVKAFFADSPNVDAFISIDGTGVGHIVYEGTGSCRYKITYSATGGHSYGDFGLPSAIHAAGRAVAAIADCRPPTEPKTTFTIGEIAGGTAVNAIASSASFHLDVRSTSPQALEQLESTFLKACEQAAEQENRHWQKHDVTVDIKRVGDRPAGRQDKEATIVQAVVQASKELGIAPTLKGAASTDSNIPIHLGIPAVTVGRGGNGGGTHTLGEWFEPVHAYLSPQRTFLAALALVGVDQVSRPLLA
>NZ_CP012475.1|WP_035202478.1|2509287_2510655_+|anion-permease
MSSQLDADNMKKPSKATYKYVVLGVLLLFLFASPFLPVPESMELRGWSALAVVTLGIGLWFTHLLPPAVTAMLLIVLFPLFGVLTFEQSAASLGKEVIWLIIAMLMMGAAVERTGLDKRIAFTILTLTKGNIRLVLLALIFVGFVLTFFLPNAIGRVVVLLPIALGVVQSLAGTGGPNVGKASMFAITYTPIICSVALITGATGSVYAASLFETMLGFEWRYLYWMAVMLPSTLAILLILWLALLWLFPIKAGKHAQGKAYFEQEKEKLGPMSFQEKTLLILYVLLITLWTTQSVHQLSISFSAVLIVIALYIPGIQLMEWKEAVAKVDWSIPLLFSAGFSMAEAFEAGGVVQWSSSLASAHLNGLPAFTLAVSLLLVVAAIRIGFTNLTAMIASLMPVALTFAAGSNVNPVWLGMICLAACSTGFLFPSQSVGTMMTYALGYYTSQELLKVGAT
>NZ_CP012475.1|WP_051881134.1|2510796_2511990_+|M20-family-metallopeptidase
MLKNKSITEKKRNIEEAVDRRDSELRQLALNIHAHPELGYQEYKASNWLSTLLEKEGFAVKRGIAGLDTAFTATWAGKAGGPVIGLLAEYDALPRLGHACGHNLIGTSSVGAALALKDAFPELQATIQVIGTPAEEGLGGKVIMCEHGVFNHLDAAMMCHPKNKTMVIRGGLARVGATFKFYGKESHAASAPEKGVSALDALVGAYNAINSLRQFFSDDVRIHGVITHGGDAANIVPGYSEASFLIRCNTRKELEHVKEKVYTAVRQSAAAVGATSKIEEHLIYAERNTNKTLANLFKENLQLMGIEVSPPPLQGGIGSSDIGNVSQLVPTIHPYIKIGEATNHTHDFTNETKSEGGLKGMNQAAKALAMTAYDLCELPGALQRVKEEFANWQLENV

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Crispr_ID: NZ_CP012475_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_3

2514363-2514597

Orphan

I-C:NA

Consensus_repeat	Method
TGTCGCACTCTATGTGAGTGCGTGGATTGAAATAT	PILER-CR
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CRISPRCasFinder
TGTGAGTGCGTGGATTGAAATA	CRT

3 spacers

The CRISPR arrays of NZ_CP012475_3

>merge|NZ_CP012475|3|2514363-2514597|PILER-CR,CRISPRCasFinder,CRT
TGTCGCACTCTATGTGAGTGCGTGGATTGAAATATTTTGAAATTGGAAATCCAATAAGTTCATTCTTGTCGCACTCTTTGTGAGTGCGTGGATTGAAATTTCGTGAAACCTCACGTCAGCATTCACTACAAAACCGTCGCACTCTATGTGAGTGCGTGGATTGAAATAATAAATGGTCTGTAGATGATCTGTACACATCTATGGCGCACTCTTCGTGAGTGCGTCGCATAAACTA

>NZ_CP012475|3|2|2514363-2514531|PILER-CR
TGTCGCACTCTATGTGAGTGCGTGGATTGAAATAT	TTTGAAATTGGAAATCCAATAAGTTCATTCT
TGTCGCACTCTTTGTGAGTGCGTGGATTGAAATTT	CGTGAAACCTCACGTCAGCATTCACTACAAAAC
CGTCGCACTCTATGTGAGTGCGTGGATTGAAATAA

>NZ_CP012475|3|3|2514364-2514596|CRISPRCasFinder
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	ATTTTGAAATTGGAAATCCAATAAGTTCATTCTT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	TTCGTGAAACCTCACGTCAGCATTCACTACAAAACC
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	AATAAATGGTCTGTAGATGATCTGTACACATCTAT
GGCGCACTCTTCGTGAGTGCGTCGCATAAACT

>NZ_CP012475|3|2|2514375-2514597|CRT
TGTGAGTGCGTGGATTGAAATA	TTTTGAAATTGGAAATCCAATAAGTTCATTCTTGTCGCACTCTT
TGTGAGTGCGTGGATTGAAATT	TCGTGAAACCTCACGTCAGCATTCACTACAAAACCGTCGCACTCTA
TGTGAGTGCGTGGATTGAAATA	ATAAATGGTCTGTAGATGATCTGTACACATCTATGGCGCACTCTT
CGTGAGTGCGTCGCATAAACTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_051881135.1\|2502397_2503978_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173863
NZ_CP012475.1\|WP_011248484.1\|2521350_2522109_+\|response-regulator	unknown	unknown	gnl\|CDD\|227095
NZ_CP012475.1\|WP_035202469.1\|2517820_2519476_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NZ_CP012475.1\|WP_035202479.1\|2508018_2509230_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349891
NZ_CP012475.1\|WP_011248497.1\|2504977_2505901_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP012475.1\|WP_035202473.1\|2514755_2515265_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|222878
NZ_CP012475.1\|WP_035202467.1\|2519675_2521346_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NZ_CP012475.1\|WP_035202463.1\|2523698_2524421_+\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|224982
NZ_CP012475.1\|WP_011248495.1\|2506933_2507968_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|185037
NZ_CP012475.1\|WP_035202475.1\|2513439_2513949_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035202472.1\|2515637_2516660_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270264
NZ_CP012475.1\|WP_011248496.1\|2505944_2506937_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP012475.1\|WP_035202481.1\|2504048_2504966_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP012475.1\|WP_035202459.1\|2525531_2526650_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP012475.1\|WP_035202465.1\|2522225_2523323_-\|RapH-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|376220
NZ_CP012475.1\|WP_035202478.1\|2509287_2510655_+\|anion-permease	unknown	unknown	gnl\|CDD\|273267
NZ_CP012475.1\|WP_051881134.1\|2510796_2511990_+\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349883
NZ_CP012475.1\|WP_035202461.1\|2524527_2525406_-\|ribokinase	unknown	unknown	gnl\|CDD\|238579
NZ_CP012475.1\|WP_094979048.1\|2512043_2513234_+\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349921
NZ_CP012475.1\|WP_035202471.1\|2516724_2517819_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_051881135.1\|2502397_2503978_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173863	cd08498, PBP2_NikA_DppA_OppA_like_2, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP012475.1\|WP_011248484.1\|2521350_2522109_+\|response-regulator	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	3.80928e-56
NZ_CP012475.1\|WP_035202469.1\|2517820_2519476_+\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	1.23708e-108
NZ_CP012475.1\|WP_035202479.1\|2508018_2509230_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349891	cd03896, M20_PAAh_like, M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins. Peptidase M20 family, Poly(aspartic acid) hydrolase (PAA hydrolase)-like subfamily. PAA hydrolase enzymes are involved in alpha,beta-poly(D,L-aspartic acid) (tPAA) biodegradation. PAA is being extensively studied as a replacement for commercial polycarboxylate components since it can be degraded by enzymes from isolated tPAA degrading bacteria. Thus far, two types of PAA degrading bacteria (Sphingomonas sp. KT-1 and Pedobacter sp. KP-2) have been investigated in detail; the former can completely degrade tPAA of low-molecular weights below 5000, while the latter can degrade high molecular weight tPAA to release oligo(aspartic acid) (OAA) as a product, suggesting two kinds of PAA degrading enzymes. It has been shown that PAA hydrolase-1 from Sphingomonas sp. KT-1 hydrolyzes beta,beta-aspartic acid units in tPAA to produce OAA, and it is suggested that PAA hydrolase-2 hydrolyzes OAA to aspartic acid. Also included in this family is Bradyrhizobium 5-nitroanthranilic acid (5NAA)-aminohydrolase (5NAA-A), a biodegradation enzyme that converts 5NAA to 5-nitrosalicylic acid; 5NAA is a metabolite secreted by Streptomyces scabies, the bacterium responsible for potato scab, and metabolized by Bradyrhizobium species strain JS329.	1.82982e-94
NZ_CP012475.1\|WP_011248497.1\|2504977_2505901_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.00257e-105
NZ_CP012475.1\|WP_035202473.1\|2514755_2515265_+\|hypothetical-protein	gnl\|CDD\|222878	PHA02562, 46, endonuclease subunit; Provisional.	0.00768773
NZ_CP012475.1\|WP_035202467.1\|2519675_2521346_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	2.38109e-46
NZ_CP012475.1\|WP_035202463.1\|2523698_2524421_+\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl\|CDD\|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	1.36759e-77
NZ_CP012475.1\|WP_011248495.1\|2506933_2507968_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|185037	PRK15079, PRK15079, oligopeptide ABC transporter ATP-binding protein OppF; Provisional.	2.10518e-150
NZ_CP012475.1\|WP_035202465.1\|2522225_2523323_-\|RapH-N-terminal-domain-containing-protein	gnl\|CDD\|376220	pfam18801, RapH_N, response regulator aspartate phosphatase H, N terminal. Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.	6.8455e-21
NZ_CP012475.1\|WP_035202472.1\|2515637_2516660_+\|extracellular-solute-binding-protein	gnl\|CDD\|270264	cd13546, PBP2_BitB, Substrate binding domain of a putative iron transporter BitB, a member of the type 2 periplasmic binding fold superfamily. The substrate domain of this group shows a high homology to the periplasmic component of ferric iron transporter (Fbp), but its biochemical characterization has not been performed. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.3958e-97
NZ_CP012475.1\|WP_011248496.1\|2505944_2506937_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	0
NZ_CP012475.1\|WP_035202481.1\|2504048_2504966_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.98814e-123
NZ_CP012475.1\|WP_035202459.1\|2525531_2526650_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.2052e-47
NZ_CP012475.1\|WP_035202478.1\|2509287_2510655_+\|anion-permease	gnl\|CDD\|273267	TIGR00785, Uncharacterized_transporter_HI_0020, anion transporter. The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds].	3.26241e-42
NZ_CP012475.1\|WP_051881134.1\|2510796_2511990_+\|M20-family-metallopeptidase	gnl\|CDD\|349883	cd03887, M20_Acy1L2, M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family. Peptidase M20 family, Aminoacylase 1-like protein 2 (ACY1L2; amidohydrolase) subfamily. This group contains many uncharacterized proteins predicted as amidohydrolases, including gene products of abgA and abgB that catalyze the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia coli, to p-aminobenzoate and glutamate. p-Aminobenzoyl-glutamate utilization is catalyzed by the abg region gene product, AbgT. Aminoacylase 1 (ACY1) proteins are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	4.47824e-158
NZ_CP012475.1\|WP_035202461.1\|2524527_2525406_-\|ribokinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	4.95627e-118
NZ_CP012475.1\|WP_094979048.1\|2512043_2513234_+\|M20-family-metallopeptidase	gnl\|CDD\|349921	cd05672, M20_ACY1L2-like, M20 Peptidase aminoacylase 1-like protein 2-like, amidohydrolase subfamily. Peptidase M20 family, aminoacylase 1-like protein 2 (ACY1L2; amidohydrolase)-like subfamily. This group contains many uncharacterized proteins predicted as amidohydrolases, including gene products of abgA and abgB that catalyze the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia coli, to p-aminobenzoate and glutamate. p-Aminobenzoyl-glutamate utilization is catalyzed by the abg region gene product, AbgT. This subfamily includes Staphylococcus aureus antibiotic resistance factor HmrA that has been shown to participate in methicillin resistance mechanisms in vivo in the presence of beta-lactams. Aminoacylase 1 (ACY1) proteins are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	1.03552e-151
NZ_CP012475.1\|WP_035202471.1\|2516724_2517819_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	4.26749e-150

>NZ_CP012475.1|WP_035202475.1|2513439_2513949_-|hypothetical-protein
MTAYAQSPEEIRESFLLVLNLMLFLYICLFTLWLIAHLIVAAALSRMAKNAHIRHPWLSWIPIAQFWIVGELISGKLRGNGGIKVLLIGCVTIVFRFLPFHQLYIHLLVKIPEPIYRFVSITLWILLIYIVYRLYEAYAKKAWIHTVLSIIPFYAPIALFVLRNRERRY
>NZ_CP012475.1|WP_094979048.1|2512043_2513234_+|M20-family-metallopeptidase
MATTILAEKQEILTALDQRDKELRELALMIHANPELSFKEYKAAEWLSAYLEKEGFQVERGVAGLETAFTAVWEGNPGGPVIGILAEYDALPNLGHACGHNLIGTAAVGAAVALKDAYPELQGTIKVIGTPAEEGGGGKIYMCDHGTFNDLDAAMMVHPKNKTMVLRGGLACMTATFSFYGKESHAASAPEKGISALDALIQSYNAINSLRQFFTDDVRIHGIITKGGDAANIVPGHCEAQFIIRAATTNRLHEIKEKVYEAVRHSSQSVGAKYKIEEGLIYAERNNNHALAELFKENWEAMGIEVEDPPKQGGIGSSDIGNVGQVTATIHPYIKIGENTNHTFEFTEDTKSEGGMKGMNQAAAGLAMTAYDLCTNPDALKAIRDEFEAWKKTQGR
>NZ_CP012475.1|WP_051881134.1|2510796_2511990_+|M20-family-metallopeptidase
MLKNKSITEKKRNIEEAVDRRDSELRQLALNIHAHPELGYQEYKASNWLSTLLEKEGFAVKRGIAGLDTAFTATWAGKAGGPVIGLLAEYDALPRLGHACGHNLIGTSSVGAALALKDAFPELQATIQVIGTPAEEGLGGKVIMCEHGVFNHLDAAMMCHPKNKTMVIRGGLARVGATFKFYGKESHAASAPEKGVSALDALVGAYNAINSLRQFFSDDVRIHGVITHGGDAANIVPGYSEASFLIRCNTRKELEHVKEKVYTAVRQSAAAVGATSKIEEHLIYAERNTNKTLANLFKENLQLMGIEVSPPPLQGGIGSSDIGNVSQLVPTIHPYIKIGEATNHTHDFTNETKSEGGLKGMNQAAKALAMTAYDLCELPGALQRVKEEFANWQLENV
>NZ_CP012475.1|WP_035202478.1|2509287_2510655_+|anion-permease
MSSQLDADNMKKPSKATYKYVVLGVLLLFLFASPFLPVPESMELRGWSALAVVTLGIGLWFTHLLPPAVTAMLLIVLFPLFGVLTFEQSAASLGKEVIWLIIAMLMMGAAVERTGLDKRIAFTILTLTKGNIRLVLLALIFVGFVLTFFLPNAIGRVVVLLPIALGVVQSLAGTGGPNVGKASMFAITYTPIICSVALITGATGSVYAASLFETMLGFEWRYLYWMAVMLPSTLAILLILWLALLWLFPIKAGKHAQGKAYFEQEKEKLGPMSFQEKTLLILYVLLITLWTTQSVHQLSISFSAVLIVIALYIPGIQLMEWKEAVAKVDWSIPLLFSAGFSMAEAFEAGGVVQWSSSLASAHLNGLPAFTLAVSLLLVVAAIRIGFTNLTAMIASLMPVALTFAAGSNVNPVWLGMICLAACSTGFLFPSQSVGTMMTYALGYYTSQELLKVGAT
>NZ_CP012475.1|WP_035202479.1|2508018_2509230_+|M20/M25/M40-family-metallo-hydrolase
MQQTYEALKNDPAIQQGLAFIEEDDEQTLAEQVAMTEIPAPPFKEAERAAYVQQKFSEYGLEAVRRDKEGNVIGAYKGVGDGPVIVLSAHLDTVFPEGTDTKVRRERDRLCAPGIFDDTRGLAEMLSIIRALHRTNVKTSGTIQFVASVGEEGIGDLRGVKAFFADSPNVDAFISIDGTGVGHIVYEGTGSCRYKITYSATGGHSYGDFGLPSAIHAAGRAVAAIADCRPPTEPKTTFTIGEIAGGTAVNAIASSASFHLDVRSTSPQALEQLESTFLKACEQAAEQENRHWQKHDVTVDIKRVGDRPAGRQDKEATIVQAVVQASKELGIAPTLKGAASTDSNIPIHLGIPAVTVGRGGNGGGTHTLGEWFEPVHAYLSPQRTFLAALALVGVDQVSRPLLA
>NZ_CP012475.1|WP_011248495.1|2506933_2507968_+|ATP-binding-cassette-domain-containing-protein
MIKEVANTKEDDTLLEIKGLKKHFDVTRKIFAKKKDILKAVDGVDFIVKKGETFGIVGESGCGKSTTGNMIMRLADPTAGSIHFEGKDLSKLAKNEQSKMKKDIQMIFQDPFSSLNPRMRVFEIIAEPLRTHKIATGKELKQQVYELLDVVGLDRSLAKRFPHEFSGGQRQRIGIARALALRPKLIVCDEPVSALDVSIQSQVLNLLSKLQKDFDLTYIFIAHGLPVVKHISDRVAVMYLGKIVETAATEELFKHPKHPYTEGLLRAIPVPDPTLRSLDSGELLEGDLPSPVNPPSGCHFRTRCPYANEKCKAEAPKLQEVAKAHYVACHYPLQAGRGVIMEHA
>NZ_CP012475.1|WP_011248496.1|2505944_2506937_+|ABC-transporter-ATP-binding-protein
MARQNRLLEVENLKTYFHTENGTVPSVDGVSFHVDRGETVAIVGESGSGKSVTSFSIMGLVSPPGKIEAGHIRFDGTELTSLSERKMRKVRGNEIAMIFQEPLTSLNPVFTVGHQISEAILLHQDTKKAEARKQGIAMLKRVGIPRAEQVYQSYPHALSGGMRQRVMIAMALSCNPKMLIADEPTTALDVTIQAQILRLLKKISKEVDTSIILITHDLGVVAELVDRVIVMYAGQIVEQADVYTIFKDPKHPYTQGLLESTPKIHELHDELKSIRGVVPVPTNMPTGCRFHPRCPHAMDICKEKEPMMVDRDGKAQVRCWLYASEKEDVG
>NZ_CP012475.1|WP_011248497.1|2504977_2505901_+|ABC-transporter-permease
MQTEQPVKHLRNHTTENRLANWTRRWARLLFKSKTGTIGLIITGLIFLLAIFAPVLSPYHPNVQNYAAMNVPPVWLEGGMKEHLLGTDNLGRDMLSRIIYGTQVSLLVGVCSVVVAGAIGMFFGLIAGYYGGFIDNVLMRIVDAFLAIPNVLFILVILGVLSPGLLTLIFVIGLTNWVIYARLVRGDVLSIKEREFIKAARTIGTKNPVIICKHVLPNVMPSFIVISTLSVATTIVLEASLSYLGLGVQPPTVSWGGMLSAGRDYLATSWWIATFPGLAIMITVLGIIFLGDWLRDVLDPRSQTLRS
>NZ_CP012475.1|WP_035202481.1|2504048_2504966_+|ABC-transporter-permease
MRKYLLWRVLQIIPVLFLISIFVFALLYLAGDPVALMLPEDATQEQVDALRESLGLDQPFYIQYLSFVGDVIQGDFGYSYRYSQPALPIVLERLPATFELAFASMIVAVLIAVPLGILSATKRNTALDVFISGASVLGKAMPNFWLGIMLILMLAITYPFFPVSGSGSMAHLILPAITLGTGCAAEMTRVLRSSMLETLNQDYVRTAVSKGVKNFFVVYKHAFRNALIPFITITFLQVSTLVSGALITEVVFSWPGLGQLLIQAINGRDMAVVQATVFIVAFIVIVVNLMADVLYRVLDPRIQFD
>NZ_CP012475.1|WP_051881135.1|2502397_2503978_+|ABC-transporter-substrate-binding-protein
MKRPFLMQMMPIVVGGLLLSGCMTNEENMTTAPDAGGEGGASSSNDTTLTIAQGSDMVSFDVHDHSNTSTEAIHVNMFSYLVKNDVEGEGIVPDLATDWELVDDETWQFTLRDDAVFHNGDPVTAEDVKFTLERVAKDNTLQEHENYRQINEVEVIDDHTFLIHTNGPQPVMLNRLSRLGSGILPKDYIEENGWDHFLQEPVGSGPYQFVEWVRDDRVVLERFDDYFGGDVAVWDQLVFRSIPESSTRVGEVIAGGVDIAMNIAPIDWNRVNENEGTSIVEGQTNRTMMLVPNHREEYPTSDPLVREAIDLAIDNQALLDNLMGGSGTPTLTRVNPGNFGANEALHGEYRYDPDRAKELLEEAGYGDGLELTLHSPDGRYLQDRETTEVIAGMLSEIGIDVKIDFMEWSAYVDLRDAHEQKDLYLIGLTGSLWDAAHQLRHHTSMVAEDHIGYSNEEFDQIYLEAEVNMDEAEREQQYIDLQTMADEELINIMLFQLDSFYAVNDRIQFEPRLDEMWRVEEITLSE
>NZ_CP012475.1|WP_035202473.1|2514755_2515265_+|hypothetical-protein
MEEKEMLELLLQKVTDLELGLKEQKEHNAAVAKDLEDQKEHNAMAAKDIKEQKGHNAAVAKDLKEQKAYNAAFAKDLKEQKTQVAGITKELKEQKEHYLAMAQDIKELKEDQLIIKQAVLETNRSVKNIKTNIENLSDQVSQLSEDQKSVREILGDHEVAIRTLRKKPV
>NZ_CP012475.1|WP_035202472.1|2515637_2516660_+|extracellular-solute-binding-protein
MKALKKFGVVVGLAVVATGCGGNGSSGDDTLVVYTTRSESLNEAVIPQFEKETGIRVQMISAGTGEAITRVESERNNPQGDVLWAADITMLYDKTDLFEEYVSPEDEYMMEGFKNTTGYFSPAFSDPTVFIVNTDLAGDMEIESFQDLLNPELKGRIAFGDPVNSSSAFQSLIAMLYAAGDGDPMSDQAWEFVKAFVANLDGKVQGSSGQVHKGVADGEYVVGLTWEDPVVHYKQSGAAVEVVFPTEGVVYPGQSIQIIKGTKNLENAKKFVDYVLSEEVQSRTGQELTVRPLREGVEVADYMTPQEEIKLFDEYDEMFIIENMDDITARYVEVLEGSMD
>NZ_CP012475.1|WP_035202471.1|2516724_2517819_+|ABC-transporter-ATP-binding-protein
MGVAIDIDNVVKMYDEHTVIDGLSLTIQPGELFTLLGPSGCGKTTLLRMIIGFNSVDGGAIKVDGQRINDVPVSKRKMGMVFQNYAIFPHMTVAENIAFGLKTLKDSKAQMQSKIDHIMKVVHIQDHHSKKPDKLSGGQQQRVALARALVINPNVLLMDEPLSNLDAKLRIEMRNAIKEIQQEVGITTVYVTHDQEEALAISDRIAVMNKGVIQQIGKPEQIYLRPTNLFVAQFIGTSNVIKAKVEKQGTDTFIVFNGEYKEKLDNVVETVENGQEVLVSVRPQEFTITQEASAIAGVVESTMFLGINTHYLVTLTTGERVEVVQHIEDKAIIPEGTNIYVKVKPHLINLFDVANEQTLMKAGE
>NZ_CP012475.1|WP_035202469.1|2517820_2519476_+|iron-ABC-transporter-permease
MRPKAFNGWNWITLSIVLFFALFILFPVVLVLNKSIYNGEAGRFTLEHFSLFFERKFYWVTLWNSIKVTVVATVLAVLIGLPLAYMLRRVKIFGSGIVQILIIVSYISPPFIGAYAWIQLLGRSGVITKWINDTFQLQFDGIYGFAGIVLVLTLQSFPLIFIYISGALKNLDNSLIEAAESLGYSGVQRVVKIVVPLIAPTILASSLLVFMRVIADFGTPMLIGEGYRTIPVLIYTQFMSEVGGDAGFAAALASIFIIVTIALFLVQRVIARQYSYSMSALRPMETKKSTGLKNLLSHVAVYGVTLLAILPQLVVVYTSFLETIGGQVYTGKFSLQNYENILFNRDLSMILNTYQLGLIAIVVIVILGILIAYLTVRKRNKVTSLLDTVSMLPFVIPGSVLAMALIFAFGEAPLYLTGTSLIMVLAFVIRRMPYTVRSSTAIVSQISPSMEEAAISLGASERRTFFRVVVPMMMPGVLAGAIMSWMTILGELSASIILYSTNTQTLAVSIYTEVIRGNFGNASAYSAILTVTSILSLFLFFKLTGKKEMNV
>NZ_CP012475.1|WP_035202467.1|2519675_2521346_+|sensor-histidine-kinase
MERRRMKDDIQRSFLTNAIVIISAILCVYLLSLLFLFNVSIVRPSQATNERVAKEVEAEFAHYKEGMARLVADEQIRAFLRGEGKSGEVNQLLYDFRNAQTFQSDFVLLDSEEEIVATSLYEGQKEQLQQSPVLREQMQQAEEHPFTGEYVNKRAFNAGQGGAYVFAAAVEEGEERAGYLLFLLEHTLPSASEQIVFVTDSFYNAVFYSHTFGIGALGKLTIPTDGFLVQYDGNPFYVTKTEVAGQPIQVITLTSVKTYQLLLLYGLLAMVVSSFVMLAVVWLVTPKILKKTLEPFDALVARISSKNNHLHFQQTDHVFAEVQTIYEEYTNKVHEIQALVDKNEEILEKKRLSEIKHLEAKFNPHFLYNVLEMIKYETLANPESAAEMIVKTAKLMRYNAHFGDTTVLLEEDIAYLRDYFALQKMRYGKRLDYTIAIEPELGRARVPKLLLQPLIENAVKHNIDGIRCLNVDVSAYWENGVLTFVVEDNGLGMTPGKMAKIKAIMAGERKEAAHTGLKNTHQMIQLLYGQRYGIDIASAPEKGEGTTVRMHIPYEG
>NZ_CP012475.1|WP_011248484.1|2521350_2522109_+|response-regulator
MLKVAIVEDEPILLKGLLYRVDWLSNDCTVVGAAEDGAEGLNLIKQTKPDIIITDIRMPFKDGLAMLKEAKADHSFEAIILSGFGEFDYAKQAITIGVHDYLLKPVDMHELEATLQKLVQKLQAQKSNDHLTKQTKVYSHLLDLGRGSHSTYVAEIMDFIKKHYHEKVTLKAASNEIGLSTVSLNDKLKEKTGYSFNELVTRYRLTKAISLLQDEKLLIYEVAEKTGFSDYKYFSQVFKKYTGMSPKQFCGK
>NZ_CP012475.1|WP_035202465.1|2522225_2523323_-|RapH-N-terminal-domain-containing-protein
MTVAVSPEKAGATIAEWYSCIIARSVEQASQLKAKVDAMFKQIEKNERLLAYYALVNFRYRLMCKQASQGGADDEMLKRAGMVAEESVDHLLKYLYYFSCGQNEFVNERYRSAITLFRKAERLLEYVENKEEEAEFHYYMGLSLYRISQYPFAGSYIEEALVEFNRLGNKERSIHCQTILGGIYSETKQYDKAVLILNEALAAAHPYPFSKMAVLRALGLNALRYHHYEQARQWFEKTLSYHEFQHTLIGVKNTYNLANTLYRLNLPQHAAPYLKKAAIGAEFYRNKEYKARCLATRGLYAEGNYALIDKAIEQLDKEGFDFEVDELAEEAATYFEQAGHTTLALKYLKIAYHAKQNLFKLGAGQ
>NZ_CP012475.1|WP_035202463.1|2523698_2524421_+|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MAKPVIGITSTIALHNQIPSVDLAEKVVKAVMNAGGVPIVLPVGNVELASDWIKACDGLILSSGEDVDPYLYKAEPSPKLQKTFKQRDEVEMELVKQALQQKKPIFAICRGIGVLNVALGGSLMQDIETGLPNACKHYQEAGRTDVTHRIQIVKDSLLHQVIGSEEIRVNSLHHQAISRLAPPLKKVASAADGVIEAVEGKAGMPYVLGVQWHPEELAANDAAMARLFTVLIERASEKSI
>NZ_CP012475.1|WP_035202461.1|2524527_2525406_-|ribokinase
MITVVGSINIDLVVHTGTMPVLGETVLGGEFQMNPGGKGANQAVAAARLGADVTMIGKVGNDPYGKLVTDNLQNEQINTDYIEVEKDGHTGVAMITVTNNDNAIVVAPGANFSWKPEDAAQYRDVFKQTNVLVLQLEVPLPFIEKIAKIGKEERCIVILNPAPAQPLPSSLLDLVDYITPNETECQTIFKQSVEQAVQRYPNKLLVTEGKKGAAYHDGQQLVQVNGFPANVVDTTGAGDTFNGALAAALASGQQLTEAVTFANAAASLSVEQAGAQAGMPSKQQVLDRLGSS
>NZ_CP012475.1|WP_035202459.1|2525531_2526650_-|HAMP-domain-containing-histidine-kinase
MGIKTRFTLHFALGLTLWLLGTGLSLVILFEVLLPLFDVVVGENTEGLLVGSIFALSTLVCIGLFGWYFGGPIAFIMRWIHQLSQGNYKQPPGLRKIYTRKETLRMRYLLYKEVLHSLQLLAEQLQANEVERKKIEQAKQEWIAGISHDLKTPLTYITGYSSLLLTNQYEWSTEEARSFTQEIYDKGKHMEELIQDLNLVLKLNDGVHPFPIHTTSQDLVEFTKRVVADISNSPQAVDYRLHFKTNKPRIDVDFDDKFMQRILQNILMNSIIHNPEPVDIYIELFDYNEQARIHITDNGIGMPTHMMENLFQQYYRGATTDSASEGTGLGMAIVYNLVRAHRGTISVESEPSKGTSFDIHFPKKGRPQDNMF

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Crispr_ID: NZ_CP012475_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_4

2564068-2564155

TypeIII

Consensus_repeat	Method
ATGTTTTATATGAACTTATTGGGT	CRISPRCasFinder

1 spacers

cas6,PD-DExK,cas10,csm3gr7,csx19

The CRISPR arrays of NZ_CP012475_4

>merge|NZ_CP012475|4|2564068-2564155|CRISPRCasFinder
ATGTTTTATATGAACTTATTGGGTATTAATCCGCATATGCTTGCGGAACTTGAGCGCTCAATGATCGTTTTATATGAACTTATTGGGT

>NZ_CP012475|4|4|2564068-2564155|CRISPRCasFinder
ATGTTTTATATGAACTTATTGGGT	ATTAATCCGCATATGCTTGCGGAACTTGAGCGCTCAATGA
TCGTTTTATATGAACTTATTGGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_035203539.1\|2565350_2565707_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035203559.1\|2554651_2555662_+\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|376910
NZ_CP012475.1\|WP_011248443.1\|2559829_2560264_+\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815
NZ_CP012475.1\|WP_035203538.1\|2566087_2567647_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP012475.1\|WP_035203545.1\|2561778_2562651_-\|ribokinase	unknown	unknown	gnl\|CDD\|274000
NZ_CP012475.1\|WP_011248449.1\|2554184_2554646_+\|ribose-5-phosphate-isomerase-B	unknown	unknown	gnl\|CDD\|376799
NZ_CP012475.1\|WP_035203547.1\|2560277_2561759_+\|tripartite-tricarboxylate-transporter-permease	unknown	unknown	gnl\|CDD\|225870
NZ_CP012475.1\|WP_035203529.1\|2576323_2576896_+\|hypothetical-protein	csx19	cls001376_csx19_CAS-III-D	gnl\|CDD\|274900
NZ_CP012475.1\|WP_035203552.1\|2557874_2558780_+\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
NZ_CP012475.1\|WP_051881184.1\|2570386_2571394_+\|hypothetical-protein	PD-DExK	mkCas0090_PD-DExK_CAS-I:CAS-III	unknown
NZ_CP012475.1\|WP_035203532.1\|2572867_2574949_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|131722
NZ_CP012475.1\|WP_035203531.1\|2574932_2576327_+\|hypothetical-protein	csm3gr7	cd09726_csm3gr7_CAS-III-D	gnl\|CDD\|187857
NZ_CP012475.1\|WP_035203541.1\|2564389_2564860_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227027
NZ_CP012475.1\|WP_035203543.1\|2562851_2563862_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP012475.1\|WP_035203554.1\|2556315_2557272_+\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|236536
NZ_CP012475.1\|WP_035203549.1\|2558846_2559818_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP012475.1\|WP_035203556.1\|2555675_2556305_+\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
NZ_CP012475.1\|WP_035203528.1\|2576876_2578802_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NZ_CP012475.1\|WP_035203536.1\|2569467_2570394_+\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	mkCas0091_cas6_CAS-I:CAS-III	gnl\|CDD\|187890
NZ_CP012475.1\|WP_035203535.1\|2571380_2572871_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|274209

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_035203531.1\|2574932_2576327_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	1.50065e-12
NZ_CP012475.1\|WP_035203559.1\|2554651_2555662_+\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|376910	pfam02733, Dak1, Dak1 domain. This is the kinase domain of the dihydroxyacetone kinase family EC:2.7.1.29.	4.6389e-162
NZ_CP012475.1\|WP_011248443.1\|2559829_2560264_+\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	0.000805338
NZ_CP012475.1\|WP_035203538.1\|2566087_2567647_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	4.29041e-146
NZ_CP012475.1\|WP_035203545.1\|2561778_2562651_-\|ribokinase	gnl\|CDD\|274000	TIGR02152, Putative_ribokinase, ribokinase. This model describes ribokinase, an enzyme catalyzing the first step in ribose catabolism. The rbsK gene encoding ribokinase typically is found with ribose transport genes. Ribokinase belongs to the carbohydrate kinase pfkB family (pfam00294). In the wide gulf between the current trusted (360 bit) and noise (100 bit) cutoffs are a number of sequences, few of which are clustered with predicted ribose transport genes but many of which are currently annotated as if having ribokinase activity. Most likely some have this function and others do not. [Energy metabolism, Sugars].	1.91803e-119
NZ_CP012475.1\|WP_011248449.1\|2554184_2554646_+\|ribose-5-phosphate-isomerase-B	gnl\|CDD\|376799	pfam02502, LacAB_rpiB, Ribose/Galactose Isomerase. This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).	5.00483e-70
NZ_CP012475.1\|WP_035203547.1\|2560277_2561759_+\|tripartite-tricarboxylate-transporter-permease	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	1.3195e-153
NZ_CP012475.1\|WP_035203552.1\|2557874_2558780_+\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	6.06963e-92
NZ_CP012475.1\|WP_035203532.1\|2572867_2574949_+\|hypothetical-protein	gnl\|CDD\|131722	TIGR02674, cas_cyan_RAMP_2, CRISPR-associated RAMP protein, Csx10 family. CRISPR is a widespread repeat family in prokaryotes. At least 45 different protein families occur in prokaryotes only when these repeats are present. This family, a minor CRISPR-associated protein family, seems largely restricted to the Cyanobacteria. It belongs to the RAMP superfamily (pfam03787).	1.35062e-14
NZ_CP012475.1\|WP_035203529.1\|2576323_2576896_+\|hypothetical-protein	gnl\|CDD\|274900	TIGR03984, hypothetical_protein_FrEUN1fDRAFT_5778, CRISPR-associated protein, TIGR03984 family. Members of this protein family are found exclusively in CRISPR-containing organisms, in operon contexts with RAMP (repeat-associated mystery protein) proteins also linked to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats).	1.17194e-23
NZ_CP012475.1\|WP_035203541.1\|2564389_2564860_-\|hypothetical-protein	gnl\|CDD\|227027	COG4682, COG4682, Predicted membrane protein [Function unknown].	2.79847e-45
NZ_CP012475.1\|WP_035203543.1\|2562851_2563862_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.4943e-99
NZ_CP012475.1\|WP_035203554.1\|2556315_2557272_+\|class-II-fructose-bisphosphatase	gnl\|CDD\|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	2.5717e-164
NZ_CP012475.1\|WP_035203549.1\|2558846_2559818_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	2.85967e-107
NZ_CP012475.1\|WP_035203556.1\|2555675_2556305_+\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	7.69854e-55
NZ_CP012475.1\|WP_035203528.1\|2576876_2578802_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	2.98649e-77
NZ_CP012475.1\|WP_035203536.1\|2569467_2570394_+\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	gnl\|CDD\|187890	cd09760, Cas6_III, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex.	1.69139e-06
NZ_CP012475.1\|WP_035203535.1\|2571380_2572871_+\|hypothetical-protein	gnl\|CDD\|274209	TIGR02578, CRISPR-associated_protein_Cas10/Csm1, CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2. A typical example is TM1811 from Thermotoga maritima. CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats. This protein family belongs to a conserved gene cluster regularly found near CRISPR repeats.	4.99421e-06

>NZ_CP012475.1|WP_035203543.1|2562851_2563862_+|LacI-family-DNA-binding-transcriptional-regulator
MKVTIKEVARHAGVSIATVSKVINNRDYVSEKTREKVKRAIGELQYEVNANAQSLKAVRSRKVAVLVSDISNTYLMSIAKAVEEMIRSIGYHMILMSHNDAPDIEYELLQIVQQQQVDAMVLIPTGENSSTIKRMVTLGVHVIAVDRKVNDLQTDYIADDNFYGSYESVRYLQSLRHQRIAVLYGHRRNSIGEERYQGALAALKEGNTYDPTLFRGANFKEEEAYRLTTELLSLPEPPTAIYSANNTMTLGVLQAIKERGLEMPNDISVIAFGDETQWKLFRPKLTLMVQQAQQIGLEAAIMLKNRLTIEKPYPVQERIIKPVLQQNETCNVLRGH
>NZ_CP012475.1|WP_035203545.1|2561778_2562651_-|ribokinase
MAIVGSINIDLVVYTSNMPVPGETVLGDKFRTNPGGKGANQAVAAARLGAAVTMVGRVGNDPYGKLATENLRNEQVETGYIDVDNAAHTGVAMITVTNNDNSIVVAPGANFSWKREDAGLYRELLRQSKVLLLQLEVPLPFIEEIAKLGKEEQCTTILNPAPAQQLSPSMLDLVDFITPNETECQTIFKQPVEQAVRNYPNKLIVTEGKKGATYHDGNRLVRVNGFLAKAVDTTGAGDTFNGAFAAALASEHPLAEAVSFANAAASLSVEKAGAQSGMPTKKQVVHRLGT
>NZ_CP012475.1|WP_035203547.1|2560277_2561759_+|tripartite-tricarboxylate-transporter-permease
MDTVMLVLQPGVLFFMLLGTFLGLFIGALPGLTATMGVAVLTPLTFWLAPQEGLAMLIAIYCTAIFASGIPAILVNTPGTPASVTTTFDGYPLTQQGKQGVALGINALYSGLGGLVSTAFLIFAAFPISKVALLFGPAEYFALAVFGLTIMVSVSSGSIIKGLISGGIGLFIVTIGLDPIRNIPRFTYDYPPLLEGLSFIPIMIGLFGLAEVFSQMLSKQTTKTGTTEKVGRILPNKAERKEVRKPFWMSSILSTCIGVIPGAGGDIASIISWNQAKNMAKGEKKAEYGKGSLGGLTASCTSNSAVIGGAFTTMMTLGLPGDAVTAILIGSLMMYGLDPGPALFTENIEMVHLIFALLIISNLLVIVVGLLGSNLFTRIIQIRQEFIHLAVVLFCIVGAYALNNSYFDVWVMVIAGFFGLLFKKLRIPLGPLILALILGPLAEANFRRAIMISGGSMDIFFTSPIAIALFVIAGLSVLIPMFRRNPKNNAPSA
>NZ_CP012475.1|WP_011248443.1|2559829_2560264_+|tripartite-tricarboxylate-transporter-TctB-family-protein
MKTANLLLNGTITVACLIFFYQTFHFPMLFGIEDSGPALFPRIALAALLLFVIIDSAVIIRKRDGEFFFTKEERGNLWRLALLIGLLVFFVFFLGKLPFLILSLVTMFLIGLVFQLKWGPALLTAVVLTFFIQFVFIKGLNIIL
>NZ_CP012475.1|WP_035203549.1|2558846_2559818_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MDRLTNLFISIVAALCLASCSNQSPEEAAERYPEDQVSLIVPFATGGASDVVSRAVAMAMEEELGVPVVVVNKTGGVGAIGVYDVMMANADGYRIGYVPVELVMYDGLQIASISPYEFAYISRLMEIPAAITVSADAPYNTLDEFITYAKEHPGELQIGNSGTGSIWHIAAGALAQEAGVEFNYVPFEGAAPAVGSLLGGHIDAVSVSPSEVKTGLDSGDLKVLGVMGNERDPVVPDVPTMKEQGYDVVLGGWGGFVAPKDTPEEIIAALDAAIEKSMETETFQTLAESRGLTPAYLPGQAFEAFAVEQYEFFNELIPSIEME
>NZ_CP012475.1|WP_035203552.1|2557874_2558780_+|dihydrodipicolinate-synthase-family-protein
MKRLYGITTAMVTPFTEAGEVDVPSVRALTDFLIEKGVHGLFPLGTTGEMNKLSIEERKQVAEAVISQAAGRVHVFIQVGAQTMGSTLELARHALEAGADGIGVVTPFFLGADDRELEEYYVTVAKQLPDDFPVYLYNIPQASANDLKPEVAERIVRRTENVVGIKYSYPDFVRLQEYSFVNGGDFSVLTGTDRLLTAALALGCDGTVSGVSGVWPEPFVRAYEAFCMGDLETARTHQSVATAYCVALKGGSNMSYFKEALKMRGIDVGGMRRPQLDLTASQLSELKSALKKVESRNSDIN
>NZ_CP012475.1|WP_035203554.1|2556315_2557272_+|class-II-fructose-bisphosphatase
MRDFLFSMAHVTEQAAVASFPWIGTGNKIEADRASTEAMRAALNRIPFRGRIAIGEGEMDEAPMLYIGEIVGNGSGPLFDLAVDPLDGTTPASKGQGDCIAVLAGAPHGTLLHAPDMYMEKLATGTEAKGAVHLDAPIEANIQAVARAKNKAVKDVTVIVQDRTRHQKLVQRARHTGAKVKLFYEVDVTAALATALPDHDIDLFVGIGGAPEGVVAAAAIKCLGGDFQGRLLPDDHQQLARCQQMGLDNPNQLLNLHDLVASQQCFFIATGVTDGLLVDGVKKRDQGELATHTFMVDGVANEIRVVQTIHRPKQVLMK
>NZ_CP012475.1|WP_035203556.1|2555675_2556305_+|dihydroxyacetone-kinase-subunit-L
MIQATDLKKALYSMRDKMAEERDYLCELDRHLGDGDHGVTMDIGWKAVAQALDDLDAETDISVICKQVAMAFLNAVGSSVGPLYATGFLQAGKPFKGKNALTSEDVATFWIAFAEGIEARGGAKIGDKTMVDTLAPMAAYLRERGGGFDGEGALAAAKKGMESTKRLQANVGRSSRLGERSIGTIDPGAASAFLLFKAFCDSVQPREKV
>NZ_CP012475.1|WP_035203559.1|2554651_2555662_+|dihydroxyacetone-kinase-subunit-DhaK
MKKLVNNPDVVVDEMIDGYLKAFPQLVEKVEGSGRALVAKQSLHGNGKVGIVIGGGSGHEPAFMGYIGRGMADGVAVGNIFASPPPQPIVEATEAVNQGNGVVYIYGNYAGDIMNFGMASDLADMEHDIKVESIIVRDDVASAPKREKEKRRGIAGEFFVTKVAGAASARGDDLSEVVRLTNKANESVRSMGVGLTPCALPQTGKPSFVLGENEMEIGLGHHGEPGVEKGPLQQADDVCDRLIDDILNDGDLKAGDDVAVLVNGLGSTTQMELFIMFRRVEQRLSEKQINIHRSYVGNYSTSMEMGGCSVTLMKVDEELKALIDAPAECPLYAQYE
>NZ_CP012475.1|WP_011248449.1|2554184_2554646_+|ribose-5-phosphate-isomerase-B
MKIAIGSDHNAFELKEELKTYMIDEGYDVVDYGCHSCEAVDYPDVSFRVGNDIMKGEIDRGILICGTGIGVAIAAGKVPGIRAALCHDTYSAERAQLSNNAQILTMGAKVIGPEAAKKVLNAYLGASFAGGPSARKIQQIAEQEQAYLEQESR
>NZ_CP012475.1|WP_035203541.1|2564389_2564860_-|hypothetical-protein
MSNEHEVLLDNEKQNEPEIKVERREGEPTGAFKGATWAALIVGVGAYFIGLFNANMELNEKGYYFVVLIFGLYSSVSLQKAVRDKDEGIPVTSIYYGISWVALIVAILLMGIGLYNAGSIVLSEKGFYGMSFVLSLFAAITVQKNIRDTQRARERD
>NZ_CP012475.1|WP_035203539.1|2565350_2565707_+|hypothetical-protein
MFFFKRDKKPTRLEVDAPDGALVLYPTELEELREKEGKHFLFFITTDEDQTGYIVTSKPDNEGPGLLFPIQEEFDVCSELFLAIPLPLSHSDSFVYKEASSYEEMTEAIEIAKNERKR
>NZ_CP012475.1|WP_035203538.1|2566087_2567647_+|BCCT-family-transporter
MKSGPIGKKRTMENKIVFPSILIIAIVSLLFAIYTEESTTLLNTIFDTIVDLFAWGYMWYALLMVVTGIWLAYSKYGQVVLGDPSEKPRYTLFEYASILVAMGVGATLMRTGMVQWSEVAVDPPFGLQDGSSEALLTGNAYSMFLWSFQTFAVFVMAAPAMAYILHVRKKPKMRISEACRVIFGDKFTDGLGGIVLDTLFLVSILAGAAVTLGLGTPIVTENLAELFNIEVTFLLTMIVTLIWVFVFTLSAYVGLDKGIKRLSTMNMYLAGVFALFIMIIGPGIFILDFFTDSVRVLVSRYLDFSLYTNSLHTEGGGSHIESHTVFWFAYNATWAMLHGVFAAVVSKGRTIKEMILTYLLAPTMLSWVATGILGGLGVERHTSGDVSVLNIVQEQEPVTAVPQILASMPIPEISISVFIIIATIFLVTTLDSTTYTIATYMSTQDMSRRAPSKHLRIFVAVVITVLALTLMNIGGLAPLEVLSGLMGIPIIAIQILTIIAAKKMMDEDKAWINNVRKEK
>NZ_CP012475.1|WP_035203536.1|2569467_2570394_+|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6
MFDHIKLLTLRVTYEAKRSGTLPPFLGTTIRGALGHCIRGFDCPTPRMKCFVCPIASRCDYANHFNSVGNEGGAVNPFVIRMVTYNKTSWKVGDKLIFEITLIGETSDHAGLFLDAFQEMEKRGFGAERIPFELKEVSDAIRKKQIWKLGRMSLRHIQPSPLVCKEREAHSVRIKFHSPVRVQVSKKVLYSLTFADIIRSISRRLALLTQAYTDKQLNWNEEAMLSAASDIQTEAQSWRLNDFKRYSMNHKDKLHIPGIEGWARFSGNITPFTPLLEAGERIHFGKNTTHGFGSFSVFYNEEEGHENV
>NZ_CP012475.1|WP_051881184.1|2570386_2571394_+|hypothetical-protein
MYKESKRKKATPQETIRGIAENYKWLEKSYANQLGIHAPNHDASTGSYRENIWLDLFERIIPKKFCISTGVFIMDSYQNVSKEVDIAIYDEQYTPYIFTGKNNLKYIPIEAVAVAIQCKSEKINSNDDIRKWAQSITKLKTSLNALTRIQTSVLDTKLDNLHSFYISQQERKNNGVSNQEPIKQVQTSTRPILILCKLNGSKTKLSDTFDIVLSINQKEVNEKGEPYQMSKQIKYEKEDLSYWYNQLNHFQLGRYGEEEETKLKEIANDQMKKFKRNLNQLRVVQNGEENITLSLTFQLNQLLMLINNPIFFPHQSYVCMFNKILNQGDGSDDSN
>NZ_CP012475.1|WP_035203535.1|2571380_2572871_+|hypothetical-protein
MTQTDSYLLALYDISGIQEYIFATNRMKENVGASRIVGDLMRSQLIKVLKEHESIKVDWQKDMEIELFSNSEFQAEVVFIGGGNALVIYRDHNLCQKVFKEISIKLIEKSYTLTLIAETLEFSYDKTTSYYPLYQELQDKLARKKEEMVRPKPFGALPISAQEHFGGFPITYKDNRSTIQALKEQATESIELEDIIDPPPKKRWAVQINDLKKSPGDDSYIAVIHIDGNGMGEQMIRKLQNLDKNGLSFAEQVKGHRELSLQISQGYKDLVQNVMKTISFEKDILPIRPLIMDGDDLTFLCQADWALPLVVEILKRMESYSGDLSLSACAGIAYVHGHFPFDIAYEIAEKCCKEAKKKRSQNGGQGSYIDFQLVRGSDVTARDVTGRPTNPNNAVLGRYRPYRVSEHEKNGVNTLIECIKQLNEKGTESEMRIPRTKQKLMYQAYLKGTEDAIKAANELLGSRGIGDFKEPKPWLDAFELADYYEQNLFKSRVVQQ
>NZ_CP012475.1|WP_035203532.1|2572867_2574949_+|hypothetical-protein
MTVYYLNITLNSELCVATGSSIAGLVDTETAHQKGFPYIPSKRIKGALHGVARELVDWGLADKLATKQLFGRAGAAESSPLHVYDGVLYQVPDPSDPDIKKKDVGEIDVDVFSQYRSESILEMFTSLRTHTALEGQVAKSHSLRTIRTVNKGIVFRSKIVLADETQLELLKQCVKGLRHLGIGRTRGLGEVECVLAEAQTVEAILSHKPAKPTNEVVFRLTLEQPLLIAGQRGLYHSSEDWIPGSTILGALAGMYITDHGLGEEAHKDEAFSRIFLQNGVKFHYAYPEHDGKVFVPCPGHFQQNKKNPTEIYDVFAKRDQLDSEDVILRSVQSLIYLEDSTVYVYEPKKEIRMHHSRPADRGVGRALGKEDDPQSGQFFQYTSLGAKQTFYGTWQGSTDDLQALIACVEKRNGQLRLGRSRTAEYGTVTMEFLEEPKQVLTDQLLRNEEYIAICLLTPMLLIDDYGRANPDPDQFLKEVEQELMPHLTLKPTRKFIKQTTLSGYNSKWRMPKPQIPALDAGTVLIVKNQEVDWEKVEQRLWGQQTGAGYGRVKVLSIKNSQTSSCFSKIEVSFSPEKMEDKGEFTKWVLQQLKQREQQKLDLANGSNVAKRAMEDKDFSRNIGQTSIHQMAELMNMKNDASVIKLIKEVKIKTKQVVMEQMFEDCKNQSREFREGYFQTLKYQVRGGAHGRKE
>NZ_CP012475.1|WP_035203531.1|2574932_2576327_+|hypothetical-protein
MAEKNNSNPISFRTCVLLEGELASPLLAGSGEEEYSDNDTVIDQYGCPFVPGSALAGVFRHQLKVRFPDELPSIKELFGKDESQSRLYVYAMTITPKAEGGFSIRDGVKLNQYKTATDQGKYNMRVVERGATWKLRFEWIEREKDQNNAIKEELLCQLIEGLMDGTITIGAKTNRGFGKLAVRRVAVKTFDHKNSKQASKSWLDWNWNDIDDKQWLRNETSLKNGPRTHLVPQEESSLRVPLLLDQTLMIRTYSKLKRVSEEEQLQAEQPDYEQLNVDHKAVIPGTTWAGAIRSRIKNVLVTQFFMEKGKADNLLEELFGTWTNGTSSTEPLKASRVRIEESVVEGGEPFPITRNAIDRFTGGTVDGALYTGEPWVNGKSELILRWSNQSTNQGSISNEAIGGMLLWAIKDLQEGLLAVGGETSVGRGIFMKDSNYSLMINGQKFTDESTCLRKAAQTVKEWNA
>NZ_CP012475.1|WP_035203529.1|2576323_2576896_+|hypothetical-protein
MKPLKVNCRRSKIEHGTTTKDALFKSIPEKLHDGFVYAVFDHAICIGKSEAGTLSFKQYTGKTIEENLDFLQEIRIFNEEREFRAVRVDGQFRWRLRMDNDEGEPTYYLDETHKLWGKAVNVQEDDWTLLKEERGTKLWFPENIKKDGEKGIVIRQYLAFGQNSYCFSDERLIGFVDWYEGGDAHGAKDY
>NZ_CP012475.1|WP_035203528.1|2576876_2578802_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MGRKIIKEGNRFVNPYNFVSLGEACEKSPYISPFEQQEKTNTGYFICELVTKTPLFIPNTSNNKALHKAEERNNDSLSDSSSFEFFSYTNLKGQPVQNQPNYEPIIPGSEIRGAVRSVHEAAFNGCLSQVIPDKSLHRRTMDTKLAGILSFDEKEKKFKIQPCERVMLNVKKGHPEGKYVDKRNYREGEKVYIKKSPEPYKGKQYMPFVVDNIEKFRKEEDWLEGYIHIGEFFPRKHHESVFVPTGATSCTVAPEQIKAFLELLQMYKENEPPHEGYKRYREELGEGSINKIPVYYNEIKENQQTYPAYLSPANLSNEIFHQKVENLLKENGGYQPCTCRQNVCPSCALFGFVSKKASQSLASRVRFSDAKIEEKNGQYFKEPVVLPELGEPKPGTVEFYTKRNTETSGETRFWTYDYKTNGKVRMKLKPTDLTIRGRKFYWHHNPKNTTTKYALTNMRQRIRPLKENQVFSFRVYFENITDQELKTLQWALDFNDGNCAHKIGRGKPLGYGSVKIQLKRLVTRSVSGNGEWLLNQYVPDPNCIGKWKHQDTEEQRDNRVVETTDQRDEILQIATFCQEIKDIISYPKGKVEGAGKNSEASHQWFTLNKRNEKRILPTIQEELFKKDNSHLKELYEIKNKR

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Crispr_ID: NZ_CP012475_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_5

2568047-2568276

TypeIII

I-C

Consensus_repeat	Method
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	PILER-CR
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CRT

3 spacers

cas6,PD-DExK,cas10,csm3gr7,csx19

The CRISPR arrays of NZ_CP012475_5

>merge|NZ_CP012475|5|2568047-2568276|PILER-CR,CRISPRCasFinder,CRT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAATGGTAATTTTCCGACCACTGTTATGCGTACCGTAGTCGCACTCTTTGTGAGTGCGTGGATTGAAATCTCAATGCCGTCCATGGAAGGGTCTGCTGGTTCGGTCGCACTCTTTGTGAGTGCGTGGATTGAAATTTTAAAGTACGGTTTGATGAAAGAGGAAAGCCGATGTCGCACTCTTTGTGAGTGCGTGGATTGAAAT

>NZ_CP012475|5|3|2568047-2568276|PILER-CR
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	GGTAATTTTCCGACCACTGTTATGCGTACCGTA
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CTCAATGCCGTCCATGGAAGGGTCTGCTGGTTCG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	TTTAAAGTACGGTTTGATGAAAGAGGAAAGCCGAT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT

>NZ_CP012475|5|5|2568047-2568276|CRISPRCasFinder
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	GGTAATTTTCCGACCACTGTTATGCGTACCGTA
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CTCAATGCCGTCCATGGAAGGGTCTGCTGGTTCG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	TTTAAAGTACGGTTTGATGAAAGAGGAAAGCCGAT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT

>NZ_CP012475|5|3|2568047-2568276|CRT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	GGTAATTTTCCGACCACTGTTATGCGTACCGTA
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CTCAATGCCGTCCATGGAAGGGTCTGCTGGTTCG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	TTTAAAGTACGGTTTGATGAAAGAGGAAAGCCGAT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_035203526.1\|2581871_2582069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035203531.1\|2574932_2576327_+\|hypothetical-protein	csm3gr7	cd09726_csm3gr7_CAS-III-D	gnl\|CDD\|187857
NZ_CP012475.1\|WP_011248443.1\|2559829_2560264_+\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815
NZ_CP012475.1\|WP_051881183.1\|2582300_2584097_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350092
NZ_CP012475.1\|WP_035203538.1\|2566087_2567647_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP012475.1\|WP_035203545.1\|2561778_2562651_-\|ribokinase	unknown	unknown	gnl\|CDD\|274000
NZ_CP012475.1\|WP_035203539.1\|2565350_2565707_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035203547.1\|2560277_2561759_+\|tripartite-tricarboxylate-transporter-permease	unknown	unknown	gnl\|CDD\|225870
NZ_CP012475.1\|WP_035203552.1\|2557874_2558780_+\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
NZ_CP012475.1\|WP_051881184.1\|2570386_2571394_+\|hypothetical-protein	PD-DExK	mkCas0090_PD-DExK_CAS-I:CAS-III	unknown
NZ_CP012475.1\|WP_035203527.1\|2580819_2581500_+\|amino-acid-racemase	unknown	unknown	gnl\|CDD\|224707
NZ_CP012475.1\|WP_035203532.1\|2572867_2574949_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|131722
NZ_CP012475.1\|WP_035203529.1\|2576323_2576896_+\|hypothetical-protein	csx19	cls001376_csx19_CAS-III-D	gnl\|CDD\|274900
NZ_CP012475.1\|WP_035203541.1\|2564389_2564860_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227027
NZ_CP012475.1\|WP_035203543.1\|2562851_2563862_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP012475.1\|WP_035203554.1\|2556315_2557272_+\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|236536
NZ_CP012475.1\|WP_035203549.1\|2558846_2559818_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP012475.1\|WP_035203528.1\|2576876_2578802_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NZ_CP012475.1\|WP_035203536.1\|2569467_2570394_+\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	mkCas0091_cas6_CAS-I:CAS-III	gnl\|CDD\|187890
NZ_CP012475.1\|WP_035203535.1\|2571380_2572871_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|274209

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_051881183.1\|2582300_2584097_+\|hypothetical-protein	gnl\|CDD\|350092	cd08978, GH_F, Glycosyl hydrolase families 43 and 62 form CAZY clan GH-F. This glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) includes family 43 (GH43) and 62 (GH62). GH43 includes enzymes with beta-xylosidase (EC 3.2.1.37), beta-1,3-xylosidase (EC 3.2.1.-), alpha-L-arabinofuranosidase (EC 3.2.1.55), arabinanase (EC 3.2.1.99), xylanase (EC 3.2.1.8), endo-alpha-L-arabinanases (beta-xylanases) and galactan 1,3-beta-galactosidase (EC 3.2.1.145) activities. GH62 includes enzymes characterized as arabinofuranosidases (alpha-L-arabinofuranosidases; EC 3.2.1.55) that specifically cleave either alpha-1,2 or alpha-1,3-L-arabinofuranose side chains from xylans. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many of the enzymes in this family display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. GH62 are also predicted to be inverting enzymes. A common structural feature of both, GH43 and GH62 enzymes, is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	1.14575e-07
NZ_CP012475.1\|WP_011248443.1\|2559829_2560264_+\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	0.000805338
NZ_CP012475.1\|WP_035203547.1\|2560277_2561759_+\|tripartite-tricarboxylate-transporter-permease	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	1.3195e-153
NZ_CP012475.1\|WP_035203545.1\|2561778_2562651_-\|ribokinase	gnl\|CDD\|274000	TIGR02152, Putative_ribokinase, ribokinase. This model describes ribokinase, an enzyme catalyzing the first step in ribose catabolism. The rbsK gene encoding ribokinase typically is found with ribose transport genes. Ribokinase belongs to the carbohydrate kinase pfkB family (pfam00294). In the wide gulf between the current trusted (360 bit) and noise (100 bit) cutoffs are a number of sequences, few of which are clustered with predicted ribose transport genes but many of which are currently annotated as if having ribokinase activity. Most likely some have this function and others do not. [Energy metabolism, Sugars].	1.91803e-119
NZ_CP012475.1\|WP_035203531.1\|2574932_2576327_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	1.50065e-12
NZ_CP012475.1\|WP_035203538.1\|2566087_2567647_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	4.29041e-146
NZ_CP012475.1\|WP_035203552.1\|2557874_2558780_+\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	6.06963e-92
NZ_CP012475.1\|WP_035203532.1\|2572867_2574949_+\|hypothetical-protein	gnl\|CDD\|131722	TIGR02674, cas_cyan_RAMP_2, CRISPR-associated RAMP protein, Csx10 family. CRISPR is a widespread repeat family in prokaryotes. At least 45 different protein families occur in prokaryotes only when these repeats are present. This family, a minor CRISPR-associated protein family, seems largely restricted to the Cyanobacteria. It belongs to the RAMP superfamily (pfam03787).	1.35062e-14
NZ_CP012475.1\|WP_035203527.1\|2580819_2581500_+\|amino-acid-racemase	gnl\|CDD\|224707	COG1794, RacX, Aspartate racemase [Cell envelope biogenesis, outer membrane].	7.4624e-63
NZ_CP012475.1\|WP_035203529.1\|2576323_2576896_+\|hypothetical-protein	gnl\|CDD\|274900	TIGR03984, hypothetical_protein_FrEUN1fDRAFT_5778, CRISPR-associated protein, TIGR03984 family. Members of this protein family are found exclusively in CRISPR-containing organisms, in operon contexts with RAMP (repeat-associated mystery protein) proteins also linked to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats).	1.17194e-23
NZ_CP012475.1\|WP_035203541.1\|2564389_2564860_-\|hypothetical-protein	gnl\|CDD\|227027	COG4682, COG4682, Predicted membrane protein [Function unknown].	2.79847e-45
NZ_CP012475.1\|WP_035203543.1\|2562851_2563862_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.4943e-99
NZ_CP012475.1\|WP_035203554.1\|2556315_2557272_+\|class-II-fructose-bisphosphatase	gnl\|CDD\|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	2.5717e-164
NZ_CP012475.1\|WP_035203549.1\|2558846_2559818_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	2.85967e-107
NZ_CP012475.1\|WP_035203528.1\|2576876_2578802_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	2.98649e-77
NZ_CP012475.1\|WP_035203536.1\|2569467_2570394_+\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	gnl\|CDD\|187890	cd09760, Cas6_III, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex.	1.69139e-06
NZ_CP012475.1\|WP_035203535.1\|2571380_2572871_+\|hypothetical-protein	gnl\|CDD\|274209	TIGR02578, CRISPR-associated_protein_Cas10/Csm1, CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2. A typical example is TM1811 from Thermotoga maritima. CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats. This protein family belongs to a conserved gene cluster regularly found near CRISPR repeats.	4.99421e-06

>NZ_CP012475.1|WP_035203538.1|2566087_2567647_+|BCCT-family-transporter
MKSGPIGKKRTMENKIVFPSILIIAIVSLLFAIYTEESTTLLNTIFDTIVDLFAWGYMWYALLMVVTGIWLAYSKYGQVVLGDPSEKPRYTLFEYASILVAMGVGATLMRTGMVQWSEVAVDPPFGLQDGSSEALLTGNAYSMFLWSFQTFAVFVMAAPAMAYILHVRKKPKMRISEACRVIFGDKFTDGLGGIVLDTLFLVSILAGAAVTLGLGTPIVTENLAELFNIEVTFLLTMIVTLIWVFVFTLSAYVGLDKGIKRLSTMNMYLAGVFALFIMIIGPGIFILDFFTDSVRVLVSRYLDFSLYTNSLHTEGGGSHIESHTVFWFAYNATWAMLHGVFAAVVSKGRTIKEMILTYLLAPTMLSWVATGILGGLGVERHTSGDVSVLNIVQEQEPVTAVPQILASMPIPEISISVFIIIATIFLVTTLDSTTYTIATYMSTQDMSRRAPSKHLRIFVAVVITVLALTLMNIGGLAPLEVLSGLMGIPIIAIQILTIIAAKKMMDEDKAWINNVRKEK
>NZ_CP012475.1|WP_035203539.1|2565350_2565707_+|hypothetical-protein
MFFFKRDKKPTRLEVDAPDGALVLYPTELEELREKEGKHFLFFITTDEDQTGYIVTSKPDNEGPGLLFPIQEEFDVCSELFLAIPLPLSHSDSFVYKEASSYEEMTEAIEIAKNERKR
>NZ_CP012475.1|WP_035203541.1|2564389_2564860_-|hypothetical-protein
MSNEHEVLLDNEKQNEPEIKVERREGEPTGAFKGATWAALIVGVGAYFIGLFNANMELNEKGYYFVVLIFGLYSSVSLQKAVRDKDEGIPVTSIYYGISWVALIVAILLMGIGLYNAGSIVLSEKGFYGMSFVLSLFAAITVQKNIRDTQRARERD
>NZ_CP012475.1|WP_035203543.1|2562851_2563862_+|LacI-family-DNA-binding-transcriptional-regulator
MKVTIKEVARHAGVSIATVSKVINNRDYVSEKTREKVKRAIGELQYEVNANAQSLKAVRSRKVAVLVSDISNTYLMSIAKAVEEMIRSIGYHMILMSHNDAPDIEYELLQIVQQQQVDAMVLIPTGENSSTIKRMVTLGVHVIAVDRKVNDLQTDYIADDNFYGSYESVRYLQSLRHQRIAVLYGHRRNSIGEERYQGALAALKEGNTYDPTLFRGANFKEEEAYRLTTELLSLPEPPTAIYSANNTMTLGVLQAIKERGLEMPNDISVIAFGDETQWKLFRPKLTLMVQQAQQIGLEAAIMLKNRLTIEKPYPVQERIIKPVLQQNETCNVLRGH
>NZ_CP012475.1|WP_035203545.1|2561778_2562651_-|ribokinase
MAIVGSINIDLVVYTSNMPVPGETVLGDKFRTNPGGKGANQAVAAARLGAAVTMVGRVGNDPYGKLATENLRNEQVETGYIDVDNAAHTGVAMITVTNNDNSIVVAPGANFSWKREDAGLYRELLRQSKVLLLQLEVPLPFIEEIAKLGKEEQCTTILNPAPAQQLSPSMLDLVDFITPNETECQTIFKQPVEQAVRNYPNKLIVTEGKKGATYHDGNRLVRVNGFLAKAVDTTGAGDTFNGAFAAALASEHPLAEAVSFANAAASLSVEKAGAQSGMPTKKQVVHRLGT
>NZ_CP012475.1|WP_035203547.1|2560277_2561759_+|tripartite-tricarboxylate-transporter-permease
MDTVMLVLQPGVLFFMLLGTFLGLFIGALPGLTATMGVAVLTPLTFWLAPQEGLAMLIAIYCTAIFASGIPAILVNTPGTPASVTTTFDGYPLTQQGKQGVALGINALYSGLGGLVSTAFLIFAAFPISKVALLFGPAEYFALAVFGLTIMVSVSSGSIIKGLISGGIGLFIVTIGLDPIRNIPRFTYDYPPLLEGLSFIPIMIGLFGLAEVFSQMLSKQTTKTGTTEKVGRILPNKAERKEVRKPFWMSSILSTCIGVIPGAGGDIASIISWNQAKNMAKGEKKAEYGKGSLGGLTASCTSNSAVIGGAFTTMMTLGLPGDAVTAILIGSLMMYGLDPGPALFTENIEMVHLIFALLIISNLLVIVVGLLGSNLFTRIIQIRQEFIHLAVVLFCIVGAYALNNSYFDVWVMVIAGFFGLLFKKLRIPLGPLILALILGPLAEANFRRAIMISGGSMDIFFTSPIAIALFVIAGLSVLIPMFRRNPKNNAPSA
>NZ_CP012475.1|WP_011248443.1|2559829_2560264_+|tripartite-tricarboxylate-transporter-TctB-family-protein
MKTANLLLNGTITVACLIFFYQTFHFPMLFGIEDSGPALFPRIALAALLLFVIIDSAVIIRKRDGEFFFTKEERGNLWRLALLIGLLVFFVFFLGKLPFLILSLVTMFLIGLVFQLKWGPALLTAVVLTFFIQFVFIKGLNIIL
>NZ_CP012475.1|WP_035203549.1|2558846_2559818_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MDRLTNLFISIVAALCLASCSNQSPEEAAERYPEDQVSLIVPFATGGASDVVSRAVAMAMEEELGVPVVVVNKTGGVGAIGVYDVMMANADGYRIGYVPVELVMYDGLQIASISPYEFAYISRLMEIPAAITVSADAPYNTLDEFITYAKEHPGELQIGNSGTGSIWHIAAGALAQEAGVEFNYVPFEGAAPAVGSLLGGHIDAVSVSPSEVKTGLDSGDLKVLGVMGNERDPVVPDVPTMKEQGYDVVLGGWGGFVAPKDTPEEIIAALDAAIEKSMETETFQTLAESRGLTPAYLPGQAFEAFAVEQYEFFNELIPSIEME
>NZ_CP012475.1|WP_035203552.1|2557874_2558780_+|dihydrodipicolinate-synthase-family-protein
MKRLYGITTAMVTPFTEAGEVDVPSVRALTDFLIEKGVHGLFPLGTTGEMNKLSIEERKQVAEAVISQAAGRVHVFIQVGAQTMGSTLELARHALEAGADGIGVVTPFFLGADDRELEEYYVTVAKQLPDDFPVYLYNIPQASANDLKPEVAERIVRRTENVVGIKYSYPDFVRLQEYSFVNGGDFSVLTGTDRLLTAALALGCDGTVSGVSGVWPEPFVRAYEAFCMGDLETARTHQSVATAYCVALKGGSNMSYFKEALKMRGIDVGGMRRPQLDLTASQLSELKSALKKVESRNSDIN
>NZ_CP012475.1|WP_035203554.1|2556315_2557272_+|class-II-fructose-bisphosphatase
MRDFLFSMAHVTEQAAVASFPWIGTGNKIEADRASTEAMRAALNRIPFRGRIAIGEGEMDEAPMLYIGEIVGNGSGPLFDLAVDPLDGTTPASKGQGDCIAVLAGAPHGTLLHAPDMYMEKLATGTEAKGAVHLDAPIEANIQAVARAKNKAVKDVTVIVQDRTRHQKLVQRARHTGAKVKLFYEVDVTAALATALPDHDIDLFVGIGGAPEGVVAAAAIKCLGGDFQGRLLPDDHQQLARCQQMGLDNPNQLLNLHDLVASQQCFFIATGVTDGLLVDGVKKRDQGELATHTFMVDGVANEIRVVQTIHRPKQVLMK
>NZ_CP012475.1|WP_035203536.1|2569467_2570394_+|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6
MFDHIKLLTLRVTYEAKRSGTLPPFLGTTIRGALGHCIRGFDCPTPRMKCFVCPIASRCDYANHFNSVGNEGGAVNPFVIRMVTYNKTSWKVGDKLIFEITLIGETSDHAGLFLDAFQEMEKRGFGAERIPFELKEVSDAIRKKQIWKLGRMSLRHIQPSPLVCKEREAHSVRIKFHSPVRVQVSKKVLYSLTFADIIRSISRRLALLTQAYTDKQLNWNEEAMLSAASDIQTEAQSWRLNDFKRYSMNHKDKLHIPGIEGWARFSGNITPFTPLLEAGERIHFGKNTTHGFGSFSVFYNEEEGHENV
>NZ_CP012475.1|WP_051881184.1|2570386_2571394_+|hypothetical-protein
MYKESKRKKATPQETIRGIAENYKWLEKSYANQLGIHAPNHDASTGSYRENIWLDLFERIIPKKFCISTGVFIMDSYQNVSKEVDIAIYDEQYTPYIFTGKNNLKYIPIEAVAVAIQCKSEKINSNDDIRKWAQSITKLKTSLNALTRIQTSVLDTKLDNLHSFYISQQERKNNGVSNQEPIKQVQTSTRPILILCKLNGSKTKLSDTFDIVLSINQKEVNEKGEPYQMSKQIKYEKEDLSYWYNQLNHFQLGRYGEEEETKLKEIANDQMKKFKRNLNQLRVVQNGEENITLSLTFQLNQLLMLINNPIFFPHQSYVCMFNKILNQGDGSDDSN
>NZ_CP012475.1|WP_035203535.1|2571380_2572871_+|hypothetical-protein
MTQTDSYLLALYDISGIQEYIFATNRMKENVGASRIVGDLMRSQLIKVLKEHESIKVDWQKDMEIELFSNSEFQAEVVFIGGGNALVIYRDHNLCQKVFKEISIKLIEKSYTLTLIAETLEFSYDKTTSYYPLYQELQDKLARKKEEMVRPKPFGALPISAQEHFGGFPITYKDNRSTIQALKEQATESIELEDIIDPPPKKRWAVQINDLKKSPGDDSYIAVIHIDGNGMGEQMIRKLQNLDKNGLSFAEQVKGHRELSLQISQGYKDLVQNVMKTISFEKDILPIRPLIMDGDDLTFLCQADWALPLVVEILKRMESYSGDLSLSACAGIAYVHGHFPFDIAYEIAEKCCKEAKKKRSQNGGQGSYIDFQLVRGSDVTARDVTGRPTNPNNAVLGRYRPYRVSEHEKNGVNTLIECIKQLNEKGTESEMRIPRTKQKLMYQAYLKGTEDAIKAANELLGSRGIGDFKEPKPWLDAFELADYYEQNLFKSRVVQQ
>NZ_CP012475.1|WP_035203532.1|2572867_2574949_+|hypothetical-protein
MTVYYLNITLNSELCVATGSSIAGLVDTETAHQKGFPYIPSKRIKGALHGVARELVDWGLADKLATKQLFGRAGAAESSPLHVYDGVLYQVPDPSDPDIKKKDVGEIDVDVFSQYRSESILEMFTSLRTHTALEGQVAKSHSLRTIRTVNKGIVFRSKIVLADETQLELLKQCVKGLRHLGIGRTRGLGEVECVLAEAQTVEAILSHKPAKPTNEVVFRLTLEQPLLIAGQRGLYHSSEDWIPGSTILGALAGMYITDHGLGEEAHKDEAFSRIFLQNGVKFHYAYPEHDGKVFVPCPGHFQQNKKNPTEIYDVFAKRDQLDSEDVILRSVQSLIYLEDSTVYVYEPKKEIRMHHSRPADRGVGRALGKEDDPQSGQFFQYTSLGAKQTFYGTWQGSTDDLQALIACVEKRNGQLRLGRSRTAEYGTVTMEFLEEPKQVLTDQLLRNEEYIAICLLTPMLLIDDYGRANPDPDQFLKEVEQELMPHLTLKPTRKFIKQTTLSGYNSKWRMPKPQIPALDAGTVLIVKNQEVDWEKVEQRLWGQQTGAGYGRVKVLSIKNSQTSSCFSKIEVSFSPEKMEDKGEFTKWVLQQLKQREQQKLDLANGSNVAKRAMEDKDFSRNIGQTSIHQMAELMNMKNDASVIKLIKEVKIKTKQVVMEQMFEDCKNQSREFREGYFQTLKYQVRGGAHGRKE
>NZ_CP012475.1|WP_035203531.1|2574932_2576327_+|hypothetical-protein
MAEKNNSNPISFRTCVLLEGELASPLLAGSGEEEYSDNDTVIDQYGCPFVPGSALAGVFRHQLKVRFPDELPSIKELFGKDESQSRLYVYAMTITPKAEGGFSIRDGVKLNQYKTATDQGKYNMRVVERGATWKLRFEWIEREKDQNNAIKEELLCQLIEGLMDGTITIGAKTNRGFGKLAVRRVAVKTFDHKNSKQASKSWLDWNWNDIDDKQWLRNETSLKNGPRTHLVPQEESSLRVPLLLDQTLMIRTYSKLKRVSEEEQLQAEQPDYEQLNVDHKAVIPGTTWAGAIRSRIKNVLVTQFFMEKGKADNLLEELFGTWTNGTSSTEPLKASRVRIEESVVEGGEPFPITRNAIDRFTGGTVDGALYTGEPWVNGKSELILRWSNQSTNQGSISNEAIGGMLLWAIKDLQEGLLAVGGETSVGRGIFMKDSNYSLMINGQKFTDESTCLRKAAQTVKEWNA
>NZ_CP012475.1|WP_035203529.1|2576323_2576896_+|hypothetical-protein
MKPLKVNCRRSKIEHGTTTKDALFKSIPEKLHDGFVYAVFDHAICIGKSEAGTLSFKQYTGKTIEENLDFLQEIRIFNEEREFRAVRVDGQFRWRLRMDNDEGEPTYYLDETHKLWGKAVNVQEDDWTLLKEERGTKLWFPENIKKDGEKGIVIRQYLAFGQNSYCFSDERLIGFVDWYEGGDAHGAKDY
>NZ_CP012475.1|WP_035203528.1|2576876_2578802_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MGRKIIKEGNRFVNPYNFVSLGEACEKSPYISPFEQQEKTNTGYFICELVTKTPLFIPNTSNNKALHKAEERNNDSLSDSSSFEFFSYTNLKGQPVQNQPNYEPIIPGSEIRGAVRSVHEAAFNGCLSQVIPDKSLHRRTMDTKLAGILSFDEKEKKFKIQPCERVMLNVKKGHPEGKYVDKRNYREGEKVYIKKSPEPYKGKQYMPFVVDNIEKFRKEEDWLEGYIHIGEFFPRKHHESVFVPTGATSCTVAPEQIKAFLELLQMYKENEPPHEGYKRYREELGEGSINKIPVYYNEIKENQQTYPAYLSPANLSNEIFHQKVENLLKENGGYQPCTCRQNVCPSCALFGFVSKKASQSLASRVRFSDAKIEEKNGQYFKEPVVLPELGEPKPGTVEFYTKRNTETSGETRFWTYDYKTNGKVRMKLKPTDLTIRGRKFYWHHNPKNTTTKYALTNMRQRIRPLKENQVFSFRVYFENITDQELKTLQWALDFNDGNCAHKIGRGKPLGYGSVKIQLKRLVTRSVSGNGEWLLNQYVPDPNCIGKWKHQDTEEQRDNRVVETTDQRDEILQIATFCQEIKDIISYPKGKVEGAGKNSEASHQWFTLNKRNEKRILPTIQEELFKKDNSHLKELYEIKNKR
>NZ_CP012475.1|WP_035203527.1|2580819_2581500_+|amino-acid-racemase
MIGILAGMGPKSTGPFVDKTVDQCQKIYGAVNDIDFPHMMIYSCPTPFYIDRPLNHKDMEMAIINGAKRLEKTGVDFIAIPCNTAHVYFDQVKNSLSIPLLNMVEETIKRVPEHSKKVALLATTPTVQSGIFQEALAKEGYEFLHQDDWQTCINQIIEKIKQGQIGESLELWDELYLQLADTIDTAIIACTDLNVVTDKKSGDISLVDSSTCLAEAIVHKYLSLKN
>NZ_CP012475.1|WP_035203526.1|2581871_2582069_-|hypothetical-protein
MSAKSKNSIEMQLLNGFVILVGLLLIFSVGHNLYVGEFNWTLLIFLAAIFAWVVFWRGFRKRRSE
>NZ_CP012475.1|WP_051881183.1|2582300_2584097_+|hypothetical-protein
MKSPLKALTVSVILLLAGLVLGDDRMEAHELPLFHFEKTLIEPSEMRYNPTGEVDFPTVIRAADYFENPLGTYYMYYGPHDAPGGIALAYADSVTGPWTEYASNPVISRNWQPHYNVSHVASAHPIWNEEEGKLFLYFHGENSVTRLASSEDGIHFDYEQVVIDTSDFTGISEASYARVFEHELDGKDNRYVMLLMGNNNGTRRIYLAWSADGREWEAQQEPLISPQPGQGGNLSGAYYFPYNGHHYVTVHGGSGNQYVVDVGENFDQEIHLGPYYQPSAVAPENGRAASRSYIYSEDELYMVYEAGQRGSTKIALARAILGDERVEMATASLRLPSRVVSTNSEIDFDVLARRYDGTTIAENELSFSLFSSDSSVVRVDGQRLYSGGEGIAEVRAEVSYQGKVITTEAISIEVRDGEVWNVIDERFDDYTRRWQIAKGSAAQGTIEQGAGFVDIIENRRSGGAYHYLTYEGFYLPNSFYTLEAELSVFAPSQGNEISIREGNRQKSLFITYDGNQGFIQDRLFQPTVAVEIDPTERARYKLVSTGQTTYDVYRNDEFLFRSTSVSQAGQNLVKVGADSQGSAALRVDALRIQTNTAP

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Crispr_ID: NZ_CP012475_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_6

2579000-2579890

TypeIII

I-C

Consensus_repeat	Method
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	PILER-CR
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	CRISPRCasFinder
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	CRT

13 spacers

csm3gr7,csx19,cas10,PD-DExK,cas6

The CRISPR arrays of NZ_CP012475_6

>merge|NZ_CP012475|6|2579000-2579890|PILER-CR,CRISPRCasFinder,CRT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAATACAAAGTGCCGTCGTTTCGCTAACATCGCCGCCATCGCACTCCTTGTGAGTGCGTGGATTGAAATCCTATGGTTTTACAAGAATTAGGTGTGTCAGCTGAGATCGCACTCCTTGTGAGTGCGTGGATTGAAATTACTTCCTCCGTAGTCGTGTCGCCGGCAGCCCGATCGCACTCCTTGTGAGTGCGTGGATTGAAATCACCCTTTAGCTTTTAATAGTCCCATCATTGCCACATCGCACTCCTTGTGAGTGCGTGGATTGAAATACCTTTACAATATAGTCCATGACATTCAAGACGTCATCGCACTCCTTGTGAGTGCGTGGATTGAAATAAACCCCATATCAGAAAAGTGATTGAGATAAATATCGCACTCCTTGTGAGTGCGTGGATTGAAATTAGAATATCGCGAGAAATCGAAGTTGCTAGGCACATCGCACTCCTTGTGAGTGCGTGGATTGAAATAGCGCTGGCCGTACGAGCGTATCCAATGCCAGTATCGCACTCCTTGTGAGTGCGTGGATTGAAATAAACAGTGTCGGATTTAAATCTTGTTGGAAATTCGATCGCACTCCTTGTGAGTGCGTGGATTGAAATGGCGACCCAATCGTGGAGTTCCGCCTCAGTGACATCGCACTCCTTGTGAGTGCGTGGATTGAAATTTTGAAAAACGTAGTCAATGCATCCTTTAAGGTTAATCGCACTCCTTGTGAGTGCGTGGATTGAAATTATTAAGTTTTCGCGGTACAAGGTTATTCCTCCTTATCGCACTCCTTGTGAGTGCGTGGATTGAAATATCAGGGTAAGTAGCTGTTCTTTTTTCATTTTTGTCGCACTCCTTGTGAGTGCGTGGATTAAAAA

>NZ_CP012475|6|4|2579000-2579890|PILER-CR
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	ACAAAGTGCCGTCGTTTCGCTAACATCGCCGCC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	CCTATGGTTTTACAAGAATTAGGTGTGTCAGCTGAG
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TACTTCCTCCGTAGTCGTGTCGCCGGCAGCCCG
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	CACCCTTTAGCTTTTAATAGTCCCATCATTGCCAC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	ACCTTTACAATATAGTCCATGACATTCAAGACGTC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AAACCCCATATCAGAAAAGTGATTGAGATAAAT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TAGAATATCGCGAGAAATCGAAGTTGCTAGGCAC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AGCGCTGGCCGTACGAGCGTATCCAATGCCAGT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AAACAGTGTCGGATTTAAATCTTGTTGGAAATTCG
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	GGCGACCCAATCGTGGAGTTCCGCCTCAGTGAC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TTTGAAAAACGTAGTCAATGCATCCTTTAAGGTTA
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TATTAAGTTTTCGCGGTACAAGGTTATTCCTCCTT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	ATCAGGGTAAGTAGCTGTTCTTTTTTCATTTTT
GTCGCACTCCTTGTGAGTGCGTGGATTAAAAA

>NZ_CP012475|6|6|2579000-2579890|CRISPRCasFinder
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	ACAAAGTGCCGTCGTTTCGCTAACATCGCCGCC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	CCTATGGTTTTACAAGAATTAGGTGTGTCAGCTGAG
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TACTTCCTCCGTAGTCGTGTCGCCGGCAGCCCG
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	CACCCTTTAGCTTTTAATAGTCCCATCATTGCCAC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	ACCTTTACAATATAGTCCATGACATTCAAGACGTC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AAACCCCATATCAGAAAAGTGATTGAGATAAAT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TAGAATATCGCGAGAAATCGAAGTTGCTAGGCAC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AGCGCTGGCCGTACGAGCGTATCCAATGCCAGT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AAACAGTGTCGGATTTAAATCTTGTTGGAAATTCG
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	GGCGACCCAATCGTGGAGTTCCGCCTCAGTGAC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TTTGAAAAACGTAGTCAATGCATCCTTTAAGGTTA
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TATTAAGTTTTCGCGGTACAAGGTTATTCCTCCTT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	ATCAGGGTAAGTAGCTGTTCTTTTTTCATTTTT
GTCGCACTCCTTGTGAGTGCGTGGATTAAAAA

>NZ_CP012475|6|4|2579000-2579890|CRT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	ACAAAGTGCCGTCGTTTCGCTAACATCGCCGCC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	CCTATGGTTTTACAAGAATTAGGTGTGTCAGCTGAG
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TACTTCCTCCGTAGTCGTGTCGCCGGCAGCCCG
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	CACCCTTTAGCTTTTAATAGTCCCATCATTGCCAC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	ACCTTTACAATATAGTCCATGACATTCAAGACGTC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AAACCCCATATCAGAAAAGTGATTGAGATAAAT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TAGAATATCGCGAGAAATCGAAGTTGCTAGGCAC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AGCGCTGGCCGTACGAGCGTATCCAATGCCAGT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AAACAGTGTCGGATTTAAATCTTGTTGGAAATTCG
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	GGCGACCCAATCGTGGAGTTCCGCCTCAGTGAC
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TTTGAAAAACGTAGTCAATGCATCCTTTAAGGTTA
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TATTAAGTTTTCGCGGTACAAGGTTATTCCTCCTT
ATCGCACTCCTTGTGAGTGCGTGGATTGAAAT	ATCAGGGTAAGTAGCTGTTCTTTTTTCATTTTT
GTCGCACTCCTTGTGAGTGCGTGGATTAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_035203526.1\|2581871_2582069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035203521.1\|2588918_2589752_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP012475.1\|WP_035203531.1\|2574932_2576327_+\|hypothetical-protein	csm3gr7	cd09726_csm3gr7_CAS-III-D	gnl\|CDD\|187857
NZ_CP012475.1\|WP_051881183.1\|2582300_2584097_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350092
NZ_CP012475.1\|WP_035203519.1\|2589778_2591143_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_CP012475.1\|WP_035203523.1\|2586714_2587980_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP012475.1\|WP_035203527.1\|2580819_2581500_+\|amino-acid-racemase	unknown	unknown	gnl\|CDD\|224707
NZ_CP012475.1\|WP_035203539.1\|2565350_2565707_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035203538.1\|2566087_2567647_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP012475.1\|WP_035203522.1\|2587999_2588929_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP012475.1\|WP_035203532.1\|2572867_2574949_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|131722
NZ_CP012475.1\|WP_035203529.1\|2576323_2576896_+\|hypothetical-protein	csx19	cls001376_csx19_CAS-III-D	gnl\|CDD\|274900
NZ_CP012475.1\|WP_035203525.1\|2584153_2584870_+\|response-regulator	unknown	unknown	gnl\|CDD\|381091
NZ_CP012475.1\|WP_035203541.1\|2564389_2564860_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227027
NZ_CP012475.1\|WP_035203524.1\|2584890_2586624_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NZ_CP012475.1\|WP_035203528.1\|2576876_2578802_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NZ_CP012475.1\|WP_051881184.1\|2570386_2571394_+\|hypothetical-protein	PD-DExK	mkCas0090_PD-DExK_CAS-I:CAS-III	unknown
NZ_CP012475.1\|WP_035203516.1\|2592301_2593627_-\|6-phospho-alpha-glucosidase	unknown	unknown	gnl\|CDD\|133434
NZ_CP012475.1\|WP_035203536.1\|2569467_2570394_+\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	mkCas0091_cas6_CAS-I:CAS-III	gnl\|CDD\|187890
NZ_CP012475.1\|WP_035203535.1\|2571380_2572871_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|274209

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_051881183.1\|2582300_2584097_+\|hypothetical-protein	gnl\|CDD\|350092	cd08978, GH_F, Glycosyl hydrolase families 43 and 62 form CAZY clan GH-F. This glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) includes family 43 (GH43) and 62 (GH62). GH43 includes enzymes with beta-xylosidase (EC 3.2.1.37), beta-1,3-xylosidase (EC 3.2.1.-), alpha-L-arabinofuranosidase (EC 3.2.1.55), arabinanase (EC 3.2.1.99), xylanase (EC 3.2.1.8), endo-alpha-L-arabinanases (beta-xylanases) and galactan 1,3-beta-galactosidase (EC 3.2.1.145) activities. GH62 includes enzymes characterized as arabinofuranosidases (alpha-L-arabinofuranosidases; EC 3.2.1.55) that specifically cleave either alpha-1,2 or alpha-1,3-L-arabinofuranose side chains from xylans. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many of the enzymes in this family display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. GH62 are also predicted to be inverting enzymes. A common structural feature of both, GH43 and GH62 enzymes, is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	1.14575e-07
NZ_CP012475.1\|WP_035203521.1\|2588918_2589752_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.94029e-90
NZ_CP012475.1\|WP_035203519.1\|2589778_2591143_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	2.08068e-149
NZ_CP012475.1\|WP_035203523.1\|2586714_2587980_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.01022e-65
NZ_CP012475.1\|WP_035203527.1\|2580819_2581500_+\|amino-acid-racemase	gnl\|CDD\|224707	COG1794, RacX, Aspartate racemase [Cell envelope biogenesis, outer membrane].	7.4624e-63
NZ_CP012475.1\|WP_035203531.1\|2574932_2576327_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	1.50065e-12
NZ_CP012475.1\|WP_035203538.1\|2566087_2567647_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	4.29041e-146
NZ_CP012475.1\|WP_035203532.1\|2572867_2574949_+\|hypothetical-protein	gnl\|CDD\|131722	TIGR02674, cas_cyan_RAMP_2, CRISPR-associated RAMP protein, Csx10 family. CRISPR is a widespread repeat family in prokaryotes. At least 45 different protein families occur in prokaryotes only when these repeats are present. This family, a minor CRISPR-associated protein family, seems largely restricted to the Cyanobacteria. It belongs to the RAMP superfamily (pfam03787).	1.35062e-14
NZ_CP012475.1\|WP_035203529.1\|2576323_2576896_+\|hypothetical-protein	gnl\|CDD\|274900	TIGR03984, hypothetical_protein_FrEUN1fDRAFT_5778, CRISPR-associated protein, TIGR03984 family. Members of this protein family are found exclusively in CRISPR-containing organisms, in operon contexts with RAMP (repeat-associated mystery protein) proteins also linked to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats).	1.17194e-23
NZ_CP012475.1\|WP_035203522.1\|2587999_2588929_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.36599e-94
NZ_CP012475.1\|WP_035203541.1\|2564389_2564860_-\|hypothetical-protein	gnl\|CDD\|227027	COG4682, COG4682, Predicted membrane protein [Function unknown].	2.79847e-45
NZ_CP012475.1\|WP_035203524.1\|2584890_2586624_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	3.61634e-55
NZ_CP012475.1\|WP_035203528.1\|2576876_2578802_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	2.98649e-77
NZ_CP012475.1\|WP_035203525.1\|2584153_2584870_+\|response-regulator	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.02798e-53
NZ_CP012475.1\|WP_035203516.1\|2592301_2593627_-\|6-phospho-alpha-glucosidase	gnl\|CDD\|133434	cd05298, GH4_GlvA_pagL_like, Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases. Bacillus subtilis GlvA and Clostridium acetobutylicum pagL are 6-phospho-alpha-glucosidase, catalyzing the hydrolysis of alpha-glucopyranoside bonds to release glucose from oligosaccharides. The substrate specificities of other members of this subgroup are unknown. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP_PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases, which include 6-phospho-beta-glucosidases, 6-phospho-alpha-glucosidases, alpha-glucosidases/alpha-glucuronidases (only from Thermotoga), and alpha-galactosidases. Members of this subfamily are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CP012475.1\|WP_035203536.1\|2569467_2570394_+\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	gnl\|CDD\|187890	cd09760, Cas6_III, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex.	1.69139e-06
NZ_CP012475.1\|WP_035203535.1\|2571380_2572871_+\|hypothetical-protein	gnl\|CDD\|274209	TIGR02578, CRISPR-associated_protein_Cas10/Csm1, CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2. A typical example is TM1811 from Thermotoga maritima. CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats. This protein family belongs to a conserved gene cluster regularly found near CRISPR repeats.	4.99421e-06

>NZ_CP012475.1|WP_035203528.1|2576876_2578802_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MGRKIIKEGNRFVNPYNFVSLGEACEKSPYISPFEQQEKTNTGYFICELVTKTPLFIPNTSNNKALHKAEERNNDSLSDSSSFEFFSYTNLKGQPVQNQPNYEPIIPGSEIRGAVRSVHEAAFNGCLSQVIPDKSLHRRTMDTKLAGILSFDEKEKKFKIQPCERVMLNVKKGHPEGKYVDKRNYREGEKVYIKKSPEPYKGKQYMPFVVDNIEKFRKEEDWLEGYIHIGEFFPRKHHESVFVPTGATSCTVAPEQIKAFLELLQMYKENEPPHEGYKRYREELGEGSINKIPVYYNEIKENQQTYPAYLSPANLSNEIFHQKVENLLKENGGYQPCTCRQNVCPSCALFGFVSKKASQSLASRVRFSDAKIEEKNGQYFKEPVVLPELGEPKPGTVEFYTKRNTETSGETRFWTYDYKTNGKVRMKLKPTDLTIRGRKFYWHHNPKNTTTKYALTNMRQRIRPLKENQVFSFRVYFENITDQELKTLQWALDFNDGNCAHKIGRGKPLGYGSVKIQLKRLVTRSVSGNGEWLLNQYVPDPNCIGKWKHQDTEEQRDNRVVETTDQRDEILQIATFCQEIKDIISYPKGKVEGAGKNSEASHQWFTLNKRNEKRILPTIQEELFKKDNSHLKELYEIKNKR
>NZ_CP012475.1|WP_035203529.1|2576323_2576896_+|hypothetical-protein
MKPLKVNCRRSKIEHGTTTKDALFKSIPEKLHDGFVYAVFDHAICIGKSEAGTLSFKQYTGKTIEENLDFLQEIRIFNEEREFRAVRVDGQFRWRLRMDNDEGEPTYYLDETHKLWGKAVNVQEDDWTLLKEERGTKLWFPENIKKDGEKGIVIRQYLAFGQNSYCFSDERLIGFVDWYEGGDAHGAKDY
>NZ_CP012475.1|WP_035203531.1|2574932_2576327_+|hypothetical-protein
MAEKNNSNPISFRTCVLLEGELASPLLAGSGEEEYSDNDTVIDQYGCPFVPGSALAGVFRHQLKVRFPDELPSIKELFGKDESQSRLYVYAMTITPKAEGGFSIRDGVKLNQYKTATDQGKYNMRVVERGATWKLRFEWIEREKDQNNAIKEELLCQLIEGLMDGTITIGAKTNRGFGKLAVRRVAVKTFDHKNSKQASKSWLDWNWNDIDDKQWLRNETSLKNGPRTHLVPQEESSLRVPLLLDQTLMIRTYSKLKRVSEEEQLQAEQPDYEQLNVDHKAVIPGTTWAGAIRSRIKNVLVTQFFMEKGKADNLLEELFGTWTNGTSSTEPLKASRVRIEESVVEGGEPFPITRNAIDRFTGGTVDGALYTGEPWVNGKSELILRWSNQSTNQGSISNEAIGGMLLWAIKDLQEGLLAVGGETSVGRGIFMKDSNYSLMINGQKFTDESTCLRKAAQTVKEWNA
>NZ_CP012475.1|WP_035203532.1|2572867_2574949_+|hypothetical-protein
MTVYYLNITLNSELCVATGSSIAGLVDTETAHQKGFPYIPSKRIKGALHGVARELVDWGLADKLATKQLFGRAGAAESSPLHVYDGVLYQVPDPSDPDIKKKDVGEIDVDVFSQYRSESILEMFTSLRTHTALEGQVAKSHSLRTIRTVNKGIVFRSKIVLADETQLELLKQCVKGLRHLGIGRTRGLGEVECVLAEAQTVEAILSHKPAKPTNEVVFRLTLEQPLLIAGQRGLYHSSEDWIPGSTILGALAGMYITDHGLGEEAHKDEAFSRIFLQNGVKFHYAYPEHDGKVFVPCPGHFQQNKKNPTEIYDVFAKRDQLDSEDVILRSVQSLIYLEDSTVYVYEPKKEIRMHHSRPADRGVGRALGKEDDPQSGQFFQYTSLGAKQTFYGTWQGSTDDLQALIACVEKRNGQLRLGRSRTAEYGTVTMEFLEEPKQVLTDQLLRNEEYIAICLLTPMLLIDDYGRANPDPDQFLKEVEQELMPHLTLKPTRKFIKQTTLSGYNSKWRMPKPQIPALDAGTVLIVKNQEVDWEKVEQRLWGQQTGAGYGRVKVLSIKNSQTSSCFSKIEVSFSPEKMEDKGEFTKWVLQQLKQREQQKLDLANGSNVAKRAMEDKDFSRNIGQTSIHQMAELMNMKNDASVIKLIKEVKIKTKQVVMEQMFEDCKNQSREFREGYFQTLKYQVRGGAHGRKE
>NZ_CP012475.1|WP_035203535.1|2571380_2572871_+|hypothetical-protein
MTQTDSYLLALYDISGIQEYIFATNRMKENVGASRIVGDLMRSQLIKVLKEHESIKVDWQKDMEIELFSNSEFQAEVVFIGGGNALVIYRDHNLCQKVFKEISIKLIEKSYTLTLIAETLEFSYDKTTSYYPLYQELQDKLARKKEEMVRPKPFGALPISAQEHFGGFPITYKDNRSTIQALKEQATESIELEDIIDPPPKKRWAVQINDLKKSPGDDSYIAVIHIDGNGMGEQMIRKLQNLDKNGLSFAEQVKGHRELSLQISQGYKDLVQNVMKTISFEKDILPIRPLIMDGDDLTFLCQADWALPLVVEILKRMESYSGDLSLSACAGIAYVHGHFPFDIAYEIAEKCCKEAKKKRSQNGGQGSYIDFQLVRGSDVTARDVTGRPTNPNNAVLGRYRPYRVSEHEKNGVNTLIECIKQLNEKGTESEMRIPRTKQKLMYQAYLKGTEDAIKAANELLGSRGIGDFKEPKPWLDAFELADYYEQNLFKSRVVQQ
>NZ_CP012475.1|WP_051881184.1|2570386_2571394_+|hypothetical-protein
MYKESKRKKATPQETIRGIAENYKWLEKSYANQLGIHAPNHDASTGSYRENIWLDLFERIIPKKFCISTGVFIMDSYQNVSKEVDIAIYDEQYTPYIFTGKNNLKYIPIEAVAVAIQCKSEKINSNDDIRKWAQSITKLKTSLNALTRIQTSVLDTKLDNLHSFYISQQERKNNGVSNQEPIKQVQTSTRPILILCKLNGSKTKLSDTFDIVLSINQKEVNEKGEPYQMSKQIKYEKEDLSYWYNQLNHFQLGRYGEEEETKLKEIANDQMKKFKRNLNQLRVVQNGEENITLSLTFQLNQLLMLINNPIFFPHQSYVCMFNKILNQGDGSDDSN
>NZ_CP012475.1|WP_035203536.1|2569467_2570394_+|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6
MFDHIKLLTLRVTYEAKRSGTLPPFLGTTIRGALGHCIRGFDCPTPRMKCFVCPIASRCDYANHFNSVGNEGGAVNPFVIRMVTYNKTSWKVGDKLIFEITLIGETSDHAGLFLDAFQEMEKRGFGAERIPFELKEVSDAIRKKQIWKLGRMSLRHIQPSPLVCKEREAHSVRIKFHSPVRVQVSKKVLYSLTFADIIRSISRRLALLTQAYTDKQLNWNEEAMLSAASDIQTEAQSWRLNDFKRYSMNHKDKLHIPGIEGWARFSGNITPFTPLLEAGERIHFGKNTTHGFGSFSVFYNEEEGHENV
>NZ_CP012475.1|WP_035203538.1|2566087_2567647_+|BCCT-family-transporter
MKSGPIGKKRTMENKIVFPSILIIAIVSLLFAIYTEESTTLLNTIFDTIVDLFAWGYMWYALLMVVTGIWLAYSKYGQVVLGDPSEKPRYTLFEYASILVAMGVGATLMRTGMVQWSEVAVDPPFGLQDGSSEALLTGNAYSMFLWSFQTFAVFVMAAPAMAYILHVRKKPKMRISEACRVIFGDKFTDGLGGIVLDTLFLVSILAGAAVTLGLGTPIVTENLAELFNIEVTFLLTMIVTLIWVFVFTLSAYVGLDKGIKRLSTMNMYLAGVFALFIMIIGPGIFILDFFTDSVRVLVSRYLDFSLYTNSLHTEGGGSHIESHTVFWFAYNATWAMLHGVFAAVVSKGRTIKEMILTYLLAPTMLSWVATGILGGLGVERHTSGDVSVLNIVQEQEPVTAVPQILASMPIPEISISVFIIIATIFLVTTLDSTTYTIATYMSTQDMSRRAPSKHLRIFVAVVITVLALTLMNIGGLAPLEVLSGLMGIPIIAIQILTIIAAKKMMDEDKAWINNVRKEK
>NZ_CP012475.1|WP_035203539.1|2565350_2565707_+|hypothetical-protein
MFFFKRDKKPTRLEVDAPDGALVLYPTELEELREKEGKHFLFFITTDEDQTGYIVTSKPDNEGPGLLFPIQEEFDVCSELFLAIPLPLSHSDSFVYKEASSYEEMTEAIEIAKNERKR
>NZ_CP012475.1|WP_035203541.1|2564389_2564860_-|hypothetical-protein
MSNEHEVLLDNEKQNEPEIKVERREGEPTGAFKGATWAALIVGVGAYFIGLFNANMELNEKGYYFVVLIFGLYSSVSLQKAVRDKDEGIPVTSIYYGISWVALIVAILLMGIGLYNAGSIVLSEKGFYGMSFVLSLFAAITVQKNIRDTQRARERD
>NZ_CP012475.1|WP_035203527.1|2580819_2581500_+|amino-acid-racemase
MIGILAGMGPKSTGPFVDKTVDQCQKIYGAVNDIDFPHMMIYSCPTPFYIDRPLNHKDMEMAIINGAKRLEKTGVDFIAIPCNTAHVYFDQVKNSLSIPLLNMVEETIKRVPEHSKKVALLATTPTVQSGIFQEALAKEGYEFLHQDDWQTCINQIIEKIKQGQIGESLELWDELYLQLADTIDTAIIACTDLNVVTDKKSGDISLVDSSTCLAEAIVHKYLSLKN
>NZ_CP012475.1|WP_035203526.1|2581871_2582069_-|hypothetical-protein
MSAKSKNSIEMQLLNGFVILVGLLLIFSVGHNLYVGEFNWTLLIFLAAIFAWVVFWRGFRKRRSE
>NZ_CP012475.1|WP_051881183.1|2582300_2584097_+|hypothetical-protein
MKSPLKALTVSVILLLAGLVLGDDRMEAHELPLFHFEKTLIEPSEMRYNPTGEVDFPTVIRAADYFENPLGTYYMYYGPHDAPGGIALAYADSVTGPWTEYASNPVISRNWQPHYNVSHVASAHPIWNEEEGKLFLYFHGENSVTRLASSEDGIHFDYEQVVIDTSDFTGISEASYARVFEHELDGKDNRYVMLLMGNNNGTRRIYLAWSADGREWEAQQEPLISPQPGQGGNLSGAYYFPYNGHHYVTVHGGSGNQYVVDVGENFDQEIHLGPYYQPSAVAPENGRAASRSYIYSEDELYMVYEAGQRGSTKIALARAILGDERVEMATASLRLPSRVVSTNSEIDFDVLARRYDGTTIAENELSFSLFSSDSSVVRVDGQRLYSGGEGIAEVRAEVSYQGKVITTEAISIEVRDGEVWNVIDERFDDYTRRWQIAKGSAAQGTIEQGAGFVDIIENRRSGGAYHYLTYEGFYLPNSFYTLEAELSVFAPSQGNEISIREGNRQKSLFITYDGNQGFIQDRLFQPTVAVEIDPTERARYKLVSTGQTTYDVYRNDEFLFRSTSVSQAGQNLVKVGADSQGSAALRVDALRIQTNTAP
>NZ_CP012475.1|WP_035203525.1|2584153_2584870_+|response-regulator
MYKVVIAEDEKMIRKGLVTIVDQLVTDFTVIGEADNGERALELLAHDCPDVLLTDIRMPKCDGLSLIREARSYYPHVKIVIVSGHEEFAYAQQAIQHGVSRYLLKPIDRTEVVLAFDEIKRGLVEPEQEDHENHLIQQVDSYIKTHIDQDITLQAVAKLVHLHPTYFSQWFKNETGQNFSTYVTQKRLERAETLLHQTNLRVYEVARMSGYQNEKHFMKLFKKEKRCTPTQFRQRALL
>NZ_CP012475.1|WP_035203524.1|2584890_2586624_+|sensor-histidine-kinase
MSLRPKIILLFLSIVLVPLNLLGMITYAYFSKTLEDQTYHYTVQVIGQVNQNVNAYIDEMHRLSLLPLYDRDILAILKNRSDVHHSYYPQTEEFERMSSFLSTLSYNRQELSGIHIITRDGSLFSDLGSPRTVHRLAEGTSDWQEAIEAGNGASLLLPTHSPSYVLGAEKSVFSVGRLLRDPDGFRPLGMIKVDIELSFIESLLEDVDLSEDASITMIDRNGEPIYETGKAIYPLLKAKGEDVWQLAERESIAVDGVDYLPVIRNDSSGDVQTIVFLPEHHIVGASQSLRLFTIGLMLAVSAVVIMLALVAERSLTKPIFELRQVMALAEKGEFHHRMNRSSKDELGQLAIGFNHMMKQINELIAKVYQTEIREKDAEIKALQTQMNPHFIYNTLEHINMMAITKQAYELSDMVASLGRLIRYSIDQKTRFVPLREELAFVESYITIQQKRLEGKVTFSIAVPEAMRSLSIPKLILQPLIENAIEHGHQHGEWPGEISIKGWQDDAYSYIEVRDSGQGMKQETIERMKEEPERGAGNQVALGNISERLLLLLGEQARLMIDSELGRGTKVTVRLPKT
>NZ_CP012475.1|WP_035203523.1|2586714_2587980_+|sugar-ABC-transporter-substrate-binding-protein
MKRWSISAGLLLVVAGCSSSGGSTDANGDEQIELTFSTWGNENHIAVYEELLEAYYVDHPNVHVTIQTTPFPDYQQNMTVLAAGQELPDIGWAAERMVPQFIENNILADLSALREDESFHFEDILPGTITQYEVGDALYGVPFSSPPHIIFYNKTLFEKNGLETPQELESRGEWTWEAFEEAAAVIAEEEGVYGANFFRAWETWENLLAHTRAEGGDLFNEDTTEFTWNSDAGISTLEMLERMMFEDRSHPRAGDQVAFEAGNVGMFFDVYSYVSTARGIEDFEWDIAPVPLGSQGRSPILGQAGYVMFEGTEHPEEALDLIRYFASETGMEATSTYFAPPRASVLESDAFIEQPGNPPRASMESTILNLSEESRVLPIHPEWQNIDNHILQGFDHLFGQTAEPADILEQMEASINPLVQE
>NZ_CP012475.1|WP_035203522.1|2587999_2588929_+|sugar-ABC-transporter-permease
MNADVQAEWRQKKKRPRKPIFKRDELAGWLFISPMLLGFTIFMFVPIGFAFYMSFTDWPLLGQSEFIGTANYQAIVQDPEFQQVMKNTVLFTAGLVPFNIILALGLALLLRHPLPGMGLFRTIVFVPVVTTLVVWAIVWRYMFATDFGFINSILAWFGIEPQAWLYNKNLAMPVVILTSVLKNVGLNMVLFLAALQMVPKNLYEAARIDGAGSWRQFKNITLPIISPTVFLATIITIIGAMKIFAQIFVMTKGGPESSTKVIVYYIWEKAFRLFDMGYASAAAFILFFVIFAFTLIQWWLRKRWVYNED
>NZ_CP012475.1|WP_035203521.1|2588918_2589752_+|carbohydrate-ABC-transporter-permease
MKINSVSTVVRYGLLTIISAIMLLPFIWMVTTSLKDPNQIFALPPTFIPNPIQWDSYINVLSSTHFLRQMFNSIYIGAAVTIGTVLLASLAGYAFARIPFKGRNVVFLAFLSVMMIPGEVTIIPLFLFMRELGWIDTHLPLMIIPIFGAGGAFGIFVMRQFFKQVPAELEDAARIDGCSRFRIFVQIMLPLSKPALATVTIFTFLTNWNEFLEPLIFINSRELMTLPLALSLFTDEAGTDWSSLMSASVLATLPVLIVFFFAQKQFIESLAMSGSKE
>NZ_CP012475.1|WP_035203519.1|2589778_2591143_+|FAD-dependent-oxidoreductase
MRQVTEIEKQVRVRAEADVVVCGGGPAGIGAALSAARNGAKTILLESHGFLGGMGTAGMVTSFAYGYHDKERFITGGIFQEIRQKLHDRGGLIMTDRKGWEPFNAEQYKILAFELLAEAGVELLCHTTVVNTITKEGTIEAIIIESKAGREALLATHVIDATGDGDVAERAGAICKIGRDKDGGTQPSSLMYVLGNVDTAALGEMLDQEGRRGYWKTEDGYRYVNATGFADEIEQAKRDGFLTKVNRDHIAAIFTVPWIDNVVGINFGRIQGKNALDPQDLTDAEVIGREQVLDGIAFLKEYVPGFKRAELLQTAPQVGIRETRRIIGDYVITQEDIVELKQFDDCIAQSCYMIDIHSPDSSTTEIYKLPKGTHYDIPYRALLPQGLNNLLVAGRCISATHEALGSFRVQAICLAIGEAAGAAAAIATKEKCLPREIDVKHLQDTLVNQGAILS
>NZ_CP012475.1|WP_035203516.1|2592301_2593627_-|6-phospho-alpha-glucosidase
MKTFNITIAGGGSTFTPGIILMLLDYLDEFPIDTIKLYDNDGDRQKTIADACAILLKERAPQVRLLASTNPEEAFTNVDFVMAHIRVGKYAMRELDEKIPLKHGVVGQETCGPGGIAYGMRSIPGVLELIDYMEKYSPEAWMLNYSNPAAIVAEATRKLRPHSKVLNICDMPIGIEELIAKNLGFASRKEMEVDYYGLNHFGWWTDIRDKNGNSLMPDVIKHVSQHGYATDGTSELEQQESWNSTLKKAREVQALDPKTVPNTYLKYYLYPDYEVAHSNKEYTRANEVMEGREKFVFGECQAIIDKGTAKETKLVIDEHASYIVDLAKAIAFNTKERMLMIVENNGAIPNFDPTAMVEIPCIVGSNGPEKLVVGEIPRFQKSLMEQQVGVEKLVVEAFEEGSYQKLWQAITLSKTVPSAKVAKDILDDLIEANKAFWPALK

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Crispr_ID: NZ_CP012475_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_7

2591556-2592117

TypeIII-D?,TypeIII-A

I-C:NA

Consensus_repeat	Method
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCACTCTNNGTGAGTGCGTGGATTGAAAT	CRT
GTGAGTGCGTGGATTGAAAT	PILER-CR

8 spacers

csm3gr7

The CRISPR arrays of NZ_CP012475_7

>merge|NZ_CP012475|7|2591556-2592117|CRISPRCasFinder,CRT,PILER-CR
GTCGCACTCTATGTGAGTGCGTGGATTGAAATCCTACAAGGGCAACAATAGTTTCACTATGATAATGTCGCACTCTTAGTGAGTGCGTGGATTGAAATCTACTTTGGTCATTTATAATCCCTACCTGCCAAGGGTCGCACTCTTAGTGAGTGCGTGGATTGAAATAAAAGGATTCCTCCATTCTCTGCATAAAATCTTCGTCGCACTCTTAGTGAGTGCGTGGATTGAAATGTCGAGATTATATAGGTATCGTCCAATTCCAAATTGTCGCACTCTTAGTGAGTGCGTGGATTGAAATGATGACACGGGCCTGAATTTCGATTGGCCGAGAAGTCGCACTCTTAGTGAGTGCGTGGATTGAAATACTTTTGTTGCGTTGCGCTCTTTGATTACTTCGGTCGCACTCTTAGTGAGTGCGTGGATTGAAATAGTTACAGCAACTTATAGCTTCACTCGGTCCAATGTCGCACTCTATGTGAGTGCGTGGATTGAAATCAAACGTGCATCTTCTTGAGTTTTCAAATTGCTACGTCGCACTCTATATGAGTGCTTGGATTGAAAT

>NZ_CP012475|7|7|2591556-2592117|CRISPRCasFinder
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	CCTACAAGGGCAACAATAGTTTCACTATGATAAT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	CTACTTTGGTCATTTATAATCCCTACCTGCCAAGG
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	AAAAGGATTCCTCCATTCTCTGCATAAAATCTTC
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	GTCGAGATTATATAGGTATCGTCCAATTCCAAATT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	GATGACACGGGCCTGAATTTCGATTGGCCGAGAA
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	ACTTTTGTTGCGTTGCGCTCTTTGATTACTTCG
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	AGTTACAGCAACTTATAGCTTCACTCGGTCCAAT
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	CAAACGTGCATCTTCTTGAGTTTTCAAATTGCTAC
GTCGCACTCTATATGAGTGCTTGGATTGAAAT

>NZ_CP012475|7|5|2591556-2592117|CRT
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	CCTACAAGGGCAACAATAGTTTCACTATGATAAT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	CTACTTTGGTCATTTATAATCCCTACCTGCCAAGG
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	AAAAGGATTCCTCCATTCTCTGCATAAAATCTTC
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	GTCGAGATTATATAGGTATCGTCCAATTCCAAATT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	GATGACACGGGCCTGAATTTCGATTGGCCGAGAA
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	ACTTTTGTTGCGTTGCGCTCTTTGATTACTTCG
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	AGTTACAGCAACTTATAGCTTCACTCGGTCCAAT
GTCGCACTCTATGTGAGTGCGTGGATTGAAAT	CAAACGTGCATCTTCTTGAGTTTTCAAATTGCTAC
GTCGCACTCTATATGAGTGCTTGGATTGAAAT

>NZ_CP012475|7|5|2591568-2592050|PILER-CR
GTGAGTGCGTGGATTGAAAT	CCTACAAGGGCAACAATAGTTTCACTATGATAATGTCGCACTCTTA
GTGAGTGCGTGGATTGAAAT	CTACTTTGGTCATTTATAATCCCTACCTGCCAAGGGTCGCACTCTTA
GTGAGTGCGTGGATTGAAAT	AAAAGGATTCCTCCATTCTCTGCATAAAATCTTCGTCGCACTCTTA
GTGAGTGCGTGGATTGAAAT	GTCGAGATTATATAGGTATCGTCCAATTCCAAATTGTCGCACTCTTA
GTGAGTGCGTGGATTGAAAT	GATGACACGGGCCTGAATTTCGATTGGCCGAGAAGTCGCACTCTTA
GTGAGTGCGTGGATTGAAAT	ACTTTTGTTGCGTTGCGCTCTTTGATTACTTCGGTCGCACTCTTA
GTGAGTGCGTGGATTGAAAT	AGTTACAGCAACTTATAGCTTCACTCGGTCCAATGTCGCACTCTAT
GTGAGTGCGTGGATTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_051881183.1\|2582300_2584097_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350092
NZ_CP012475.1\|WP_035203521.1\|2588918_2589752_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP012475.1\|WP_035203504.1\|2597493_2598228_+\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|378155
NZ_CP012475.1\|WP_035203498.1\|2599623_2600568_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238570
NZ_CP012475.1\|WP_035203519.1\|2589778_2591143_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_CP012475.1\|WP_035203523.1\|2586714_2587980_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP012475.1\|WP_035203527.1\|2580819_2581500_+\|amino-acid-racemase	unknown	unknown	gnl\|CDD\|224707
NZ_CP012475.1\|WP_035203526.1\|2581871_2582069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035203507.1\|2596951_2597425_+\|DUF5381-family-protein	unknown	unknown	gnl\|CDD\|375146
NZ_CP012475.1\|WP_011248416.1\|2596270_2596756_+\|DUF1648-domain-containing-protein	unknown	unknown	gnl\|CDD\|377929
NZ_CP012475.1\|WP_011248411.1\|2600750_2601539_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP012475.1\|WP_035203510.1\|2595384_2596152_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP012475.1\|WP_011248410.1\|2601531_2602011_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NZ_CP012475.1\|WP_035203501.1\|2598258_2598792_+\|HXXEE-domain-containing-protein	unknown	unknown	gnl\|CDD\|379370
NZ_CP012475.1\|WP_035203524.1\|2584890_2586624_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NZ_CP012475.1\|WP_035203528.1\|2576876_2578802_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NZ_CP012475.1\|WP_035203525.1\|2584153_2584870_+\|response-regulator	unknown	unknown	gnl\|CDD\|381091
NZ_CP012475.1\|WP_035203516.1\|2592301_2593627_-\|6-phospho-alpha-glucosidase	unknown	unknown	gnl\|CDD\|133434
NZ_CP012475.1\|WP_035203522.1\|2587999_2588929_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP012475.1\|WP_035203513.1\|2593656_2595240_-\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273925

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_051881183.1\|2582300_2584097_+\|hypothetical-protein	gnl\|CDD\|350092	cd08978, GH_F, Glycosyl hydrolase families 43 and 62 form CAZY clan GH-F. This glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) includes family 43 (GH43) and 62 (GH62). GH43 includes enzymes with beta-xylosidase (EC 3.2.1.37), beta-1,3-xylosidase (EC 3.2.1.-), alpha-L-arabinofuranosidase (EC 3.2.1.55), arabinanase (EC 3.2.1.99), xylanase (EC 3.2.1.8), endo-alpha-L-arabinanases (beta-xylanases) and galactan 1,3-beta-galactosidase (EC 3.2.1.145) activities. GH62 includes enzymes characterized as arabinofuranosidases (alpha-L-arabinofuranosidases; EC 3.2.1.55) that specifically cleave either alpha-1,2 or alpha-1,3-L-arabinofuranose side chains from xylans. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many of the enzymes in this family display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. GH62 are also predicted to be inverting enzymes. A common structural feature of both, GH43 and GH62 enzymes, is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	1.14575e-07
NZ_CP012475.1\|WP_035203521.1\|2588918_2589752_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.94029e-90
NZ_CP012475.1\|WP_035203504.1\|2597493_2598228_+\|SMI1/KNR4-family-protein	gnl\|CDD\|378155	pfam09346, SMI1_KNR4, SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.	9.06235e-06
NZ_CP012475.1\|WP_035203498.1\|2599623_2600568_-\|hypothetical-protein	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	4.17429e-65
NZ_CP012475.1\|WP_035203519.1\|2589778_2591143_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	2.08068e-149
NZ_CP012475.1\|WP_035203523.1\|2586714_2587980_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.01022e-65
NZ_CP012475.1\|WP_035203516.1\|2592301_2593627_-\|6-phospho-alpha-glucosidase	gnl\|CDD\|133434	cd05298, GH4_GlvA_pagL_like, Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases. Bacillus subtilis GlvA and Clostridium acetobutylicum pagL are 6-phospho-alpha-glucosidase, catalyzing the hydrolysis of alpha-glucopyranoside bonds to release glucose from oligosaccharides. The substrate specificities of other members of this subgroup are unknown. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP_PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases, which include 6-phospho-beta-glucosidases, 6-phospho-alpha-glucosidases, alpha-glucosidases/alpha-glucuronidases (only from Thermotoga), and alpha-galactosidases. Members of this subfamily are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CP012475.1\|WP_035203507.1\|2596951_2597425_+\|DUF5381-family-protein	gnl\|CDD\|375146	pfam17353, DUF5381, Family of unknown function (DUF5381). This is a family of unknown function found in Bacillales.	0.00423398
NZ_CP012475.1\|WP_011248416.1\|2596270_2596756_+\|DUF1648-domain-containing-protein	gnl\|CDD\|377929	pfam07853, DUF1648, Protein of unknown function (DUF1648). Members of this family are hypothetical proteins expressed by either bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues.	0.00239141
NZ_CP012475.1\|WP_011248411.1\|2600750_2601539_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	4.3258e-90
NZ_CP012475.1\|WP_035203510.1\|2595384_2596152_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	4.54204e-36
NZ_CP012475.1\|WP_011248410.1\|2601531_2602011_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	2.57201e-35
NZ_CP012475.1\|WP_035203501.1\|2598258_2598792_+\|HXXEE-domain-containing-protein	gnl\|CDD\|379370	pfam13787, HXXEE, Protein of unknown function with HXXEE motif. This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.	6.0163e-17
NZ_CP012475.1\|WP_035203524.1\|2584890_2586624_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	3.61634e-55
NZ_CP012475.1\|WP_035203528.1\|2576876_2578802_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	2.98649e-77
NZ_CP012475.1\|WP_035203525.1\|2584153_2584870_+\|response-regulator	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.02798e-53
NZ_CP012475.1\|WP_035203527.1\|2580819_2581500_+\|amino-acid-racemase	gnl\|CDD\|224707	COG1794, RacX, Aspartate racemase [Cell envelope biogenesis, outer membrane].	7.4624e-63
NZ_CP012475.1\|WP_035203522.1\|2587999_2588929_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.36599e-94
NZ_CP012475.1\|WP_035203513.1\|2593656_2595240_-\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273925	TIGR02005, PTS-IIBC-alpha, PTS system, alpha-glucoside-specific IIBC component. This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0

>NZ_CP012475.1|WP_035203519.1|2589778_2591143_+|FAD-dependent-oxidoreductase
MRQVTEIEKQVRVRAEADVVVCGGGPAGIGAALSAARNGAKTILLESHGFLGGMGTAGMVTSFAYGYHDKERFITGGIFQEIRQKLHDRGGLIMTDRKGWEPFNAEQYKILAFELLAEAGVELLCHTTVVNTITKEGTIEAIIIESKAGREALLATHVIDATGDGDVAERAGAICKIGRDKDGGTQPSSLMYVLGNVDTAALGEMLDQEGRRGYWKTEDGYRYVNATGFADEIEQAKRDGFLTKVNRDHIAAIFTVPWIDNVVGINFGRIQGKNALDPQDLTDAEVIGREQVLDGIAFLKEYVPGFKRAELLQTAPQVGIRETRRIIGDYVITQEDIVELKQFDDCIAQSCYMIDIHSPDSSTTEIYKLPKGTHYDIPYRALLPQGLNNLLVAGRCISATHEALGSFRVQAICLAIGEAAGAAAAIATKEKCLPREIDVKHLQDTLVNQGAILS
>NZ_CP012475.1|WP_035203521.1|2588918_2589752_+|carbohydrate-ABC-transporter-permease
MKINSVSTVVRYGLLTIISAIMLLPFIWMVTTSLKDPNQIFALPPTFIPNPIQWDSYINVLSSTHFLRQMFNSIYIGAAVTIGTVLLASLAGYAFARIPFKGRNVVFLAFLSVMMIPGEVTIIPLFLFMRELGWIDTHLPLMIIPIFGAGGAFGIFVMRQFFKQVPAELEDAARIDGCSRFRIFVQIMLPLSKPALATVTIFTFLTNWNEFLEPLIFINSRELMTLPLALSLFTDEAGTDWSSLMSASVLATLPVLIVFFFAQKQFIESLAMSGSKE
>NZ_CP012475.1|WP_035203522.1|2587999_2588929_+|sugar-ABC-transporter-permease
MNADVQAEWRQKKKRPRKPIFKRDELAGWLFISPMLLGFTIFMFVPIGFAFYMSFTDWPLLGQSEFIGTANYQAIVQDPEFQQVMKNTVLFTAGLVPFNIILALGLALLLRHPLPGMGLFRTIVFVPVVTTLVVWAIVWRYMFATDFGFINSILAWFGIEPQAWLYNKNLAMPVVILTSVLKNVGLNMVLFLAALQMVPKNLYEAARIDGAGSWRQFKNITLPIISPTVFLATIITIIGAMKIFAQIFVMTKGGPESSTKVIVYYIWEKAFRLFDMGYASAAAFILFFVIFAFTLIQWWLRKRWVYNED
>NZ_CP012475.1|WP_035203523.1|2586714_2587980_+|sugar-ABC-transporter-substrate-binding-protein
MKRWSISAGLLLVVAGCSSSGGSTDANGDEQIELTFSTWGNENHIAVYEELLEAYYVDHPNVHVTIQTTPFPDYQQNMTVLAAGQELPDIGWAAERMVPQFIENNILADLSALREDESFHFEDILPGTITQYEVGDALYGVPFSSPPHIIFYNKTLFEKNGLETPQELESRGEWTWEAFEEAAAVIAEEEGVYGANFFRAWETWENLLAHTRAEGGDLFNEDTTEFTWNSDAGISTLEMLERMMFEDRSHPRAGDQVAFEAGNVGMFFDVYSYVSTARGIEDFEWDIAPVPLGSQGRSPILGQAGYVMFEGTEHPEEALDLIRYFASETGMEATSTYFAPPRASVLESDAFIEQPGNPPRASMESTILNLSEESRVLPIHPEWQNIDNHILQGFDHLFGQTAEPADILEQMEASINPLVQE
>NZ_CP012475.1|WP_035203524.1|2584890_2586624_+|sensor-histidine-kinase
MSLRPKIILLFLSIVLVPLNLLGMITYAYFSKTLEDQTYHYTVQVIGQVNQNVNAYIDEMHRLSLLPLYDRDILAILKNRSDVHHSYYPQTEEFERMSSFLSTLSYNRQELSGIHIITRDGSLFSDLGSPRTVHRLAEGTSDWQEAIEAGNGASLLLPTHSPSYVLGAEKSVFSVGRLLRDPDGFRPLGMIKVDIELSFIESLLEDVDLSEDASITMIDRNGEPIYETGKAIYPLLKAKGEDVWQLAERESIAVDGVDYLPVIRNDSSGDVQTIVFLPEHHIVGASQSLRLFTIGLMLAVSAVVIMLALVAERSLTKPIFELRQVMALAEKGEFHHRMNRSSKDELGQLAIGFNHMMKQINELIAKVYQTEIREKDAEIKALQTQMNPHFIYNTLEHINMMAITKQAYELSDMVASLGRLIRYSIDQKTRFVPLREELAFVESYITIQQKRLEGKVTFSIAVPEAMRSLSIPKLILQPLIENAIEHGHQHGEWPGEISIKGWQDDAYSYIEVRDSGQGMKQETIERMKEEPERGAGNQVALGNISERLLLLLGEQARLMIDSELGRGTKVTVRLPKT
>NZ_CP012475.1|WP_035203525.1|2584153_2584870_+|response-regulator
MYKVVIAEDEKMIRKGLVTIVDQLVTDFTVIGEADNGERALELLAHDCPDVLLTDIRMPKCDGLSLIREARSYYPHVKIVIVSGHEEFAYAQQAIQHGVSRYLLKPIDRTEVVLAFDEIKRGLVEPEQEDHENHLIQQVDSYIKTHIDQDITLQAVAKLVHLHPTYFSQWFKNETGQNFSTYVTQKRLERAETLLHQTNLRVYEVARMSGYQNEKHFMKLFKKEKRCTPTQFRQRALL
>NZ_CP012475.1|WP_051881183.1|2582300_2584097_+|hypothetical-protein
MKSPLKALTVSVILLLAGLVLGDDRMEAHELPLFHFEKTLIEPSEMRYNPTGEVDFPTVIRAADYFENPLGTYYMYYGPHDAPGGIALAYADSVTGPWTEYASNPVISRNWQPHYNVSHVASAHPIWNEEEGKLFLYFHGENSVTRLASSEDGIHFDYEQVVIDTSDFTGISEASYARVFEHELDGKDNRYVMLLMGNNNGTRRIYLAWSADGREWEAQQEPLISPQPGQGGNLSGAYYFPYNGHHYVTVHGGSGNQYVVDVGENFDQEIHLGPYYQPSAVAPENGRAASRSYIYSEDELYMVYEAGQRGSTKIALARAILGDERVEMATASLRLPSRVVSTNSEIDFDVLARRYDGTTIAENELSFSLFSSDSSVVRVDGQRLYSGGEGIAEVRAEVSYQGKVITTEAISIEVRDGEVWNVIDERFDDYTRRWQIAKGSAAQGTIEQGAGFVDIIENRRSGGAYHYLTYEGFYLPNSFYTLEAELSVFAPSQGNEISIREGNRQKSLFITYDGNQGFIQDRLFQPTVAVEIDPTERARYKLVSTGQTTYDVYRNDEFLFRSTSVSQAGQNLVKVGADSQGSAALRVDALRIQTNTAP
>NZ_CP012475.1|WP_035203526.1|2581871_2582069_-|hypothetical-protein
MSAKSKNSIEMQLLNGFVILVGLLLIFSVGHNLYVGEFNWTLLIFLAAIFAWVVFWRGFRKRRSE
>NZ_CP012475.1|WP_035203527.1|2580819_2581500_+|amino-acid-racemase
MIGILAGMGPKSTGPFVDKTVDQCQKIYGAVNDIDFPHMMIYSCPTPFYIDRPLNHKDMEMAIINGAKRLEKTGVDFIAIPCNTAHVYFDQVKNSLSIPLLNMVEETIKRVPEHSKKVALLATTPTVQSGIFQEALAKEGYEFLHQDDWQTCINQIIEKIKQGQIGESLELWDELYLQLADTIDTAIIACTDLNVVTDKKSGDISLVDSSTCLAEAIVHKYLSLKN
>NZ_CP012475.1|WP_035203528.1|2576876_2578802_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MGRKIIKEGNRFVNPYNFVSLGEACEKSPYISPFEQQEKTNTGYFICELVTKTPLFIPNTSNNKALHKAEERNNDSLSDSSSFEFFSYTNLKGQPVQNQPNYEPIIPGSEIRGAVRSVHEAAFNGCLSQVIPDKSLHRRTMDTKLAGILSFDEKEKKFKIQPCERVMLNVKKGHPEGKYVDKRNYREGEKVYIKKSPEPYKGKQYMPFVVDNIEKFRKEEDWLEGYIHIGEFFPRKHHESVFVPTGATSCTVAPEQIKAFLELLQMYKENEPPHEGYKRYREELGEGSINKIPVYYNEIKENQQTYPAYLSPANLSNEIFHQKVENLLKENGGYQPCTCRQNVCPSCALFGFVSKKASQSLASRVRFSDAKIEEKNGQYFKEPVVLPELGEPKPGTVEFYTKRNTETSGETRFWTYDYKTNGKVRMKLKPTDLTIRGRKFYWHHNPKNTTTKYALTNMRQRIRPLKENQVFSFRVYFENITDQELKTLQWALDFNDGNCAHKIGRGKPLGYGSVKIQLKRLVTRSVSGNGEWLLNQYVPDPNCIGKWKHQDTEEQRDNRVVETTDQRDEILQIATFCQEIKDIISYPKGKVEGAGKNSEASHQWFTLNKRNEKRILPTIQEELFKKDNSHLKELYEIKNKR
>NZ_CP012475.1|WP_035203516.1|2592301_2593627_-|6-phospho-alpha-glucosidase
MKTFNITIAGGGSTFTPGIILMLLDYLDEFPIDTIKLYDNDGDRQKTIADACAILLKERAPQVRLLASTNPEEAFTNVDFVMAHIRVGKYAMRELDEKIPLKHGVVGQETCGPGGIAYGMRSIPGVLELIDYMEKYSPEAWMLNYSNPAAIVAEATRKLRPHSKVLNICDMPIGIEELIAKNLGFASRKEMEVDYYGLNHFGWWTDIRDKNGNSLMPDVIKHVSQHGYATDGTSELEQQESWNSTLKKAREVQALDPKTVPNTYLKYYLYPDYEVAHSNKEYTRANEVMEGREKFVFGECQAIIDKGTAKETKLVIDEHASYIVDLAKAIAFNTKERMLMIVENNGAIPNFDPTAMVEIPCIVGSNGPEKLVVGEIPRFQKSLMEQQVGVEKLVVEAFEEGSYQKLWQAITLSKTVPSAKVAKDILDDLIEANKAFWPALK
>NZ_CP012475.1|WP_035203513.1|2593656_2595240_-|PTS-transporter-subunit-EIIC
MNAIKRFGSAMIVPVLLFAFFGIVVGLATLFKNPAIMGDIAAEGTMWYKVWSLIESGGWTIFNHMELAFVIGLPISLAKKAQARATLAALMVYLVFNNFINAILTLWPSTFGVDLSQGVENITGVKEIAGIPTLDTNIIGAIVISAIVIWIHNRFYDQKLPEMLGIFQGLVFVVIIGFFVMIPFAFLVAFVWPYVQQGIGSLQGFISQAGYVGVWLFHFLERVLIPTGLHHFIYTPFEFGPAAVNEGLKPYWIANLNDFATSTSALKDLYPYGFLLHGNIKMFGCLGIALAMYYSTPKENRKKVLALVLPATLTAIFAGITEPLEFTFLFIAPYLFVIHALLGATMVTLMNMFGVVGMMGGGLIEIVALNWIPLASNHGSIYIVQAMIGLIFAALYFVLFRWMIVKFDIPLPGRKKEEEARLYTKQDYQKAKKGSNHEKEAAAAYESEYEEKAVYYLEGLGGKENIKDVTNCATRLRVTVIDPSLVKDSDYFTNNKMAHGVAKSGQSIQIIVGLSVPQVRDSFETKL
>NZ_CP012475.1|WP_035203510.1|2595384_2596152_+|MurR/RpiR-family-transcriptional-regulator
MILDKLVNKHFESLSENDLHIIKTIYDHIDEMKTMKIQDLAVYAHTSISSIHRLTKKIGLDGYSDLKSYIKLNNFTEGTSQDLMELLDQDIHQTRKYMEQLDFCQLNRLIDRAPYIYIYGTGAAQLDLANDVQRQLWTLHKKSQVIRSERDFTNGLGEMGENDLLFIISLSGESENLDEIIHAIKTRKIKCVSLTTLRNNLLAQNAMFNIYVNSTPFWLYNKVENSSFLPFYIVVDIIVRKFSEWKMEQLKNNMT
>NZ_CP012475.1|WP_011248416.1|2596270_2596756_+|DUF1648-domain-containing-protein
MEKPKNGHSKIENLLVFLSAVFFIYHLTFLINAWPDIPNQIAFHYSNGIPDNFRPKYLLIVIPLIGVLMWCLLGFLVRKPEKLNYINLTEANKDLQYMKARKIMSVVQNASFIMLLFANEAFIRGAMGLEFSFQLSISLLLLVICNLTPLYFLIWAFRLKY
>NZ_CP012475.1|WP_035203507.1|2596951_2597425_+|DUF5381-family-protein
MKAISYRKSVAWGKALGSLLFVLVCLFLLYVAFFTDATLIHTFFCITSAIIGIPFFGGYLVVCLPRALKSNTQLLTYDQQAISDGKQTVAWVDIVKISYSGPSIQRWLLPQFPKLIFHLKNRETWTVNTYYLLTDTEIQSVMKLLHGLIGRNGKEIK
>NZ_CP012475.1|WP_035203504.1|2597493_2598228_+|SMI1/KNR4-family-protein
MEASIEGLLRLLRDQHEAHHGIPESEIEAKERELGFSLPLVLRNYYKALGRSPHISQGCNNQYEPLPLEKLFIPDSTFFTTDKAFLVFYQVEESVIYCGIRLDELEKEDPPVYLCAWSFADWQLENQSLSRFLAGKALVQLGVEDRLPYWAIFDESTGNLSDYHEWMRLDDHEDEIEEGSELNTWKIFVKDDVLIVFELSGSEEEEAPLAVYLASFKRTNLENLLNELEKAANLPAYRTNLFEQ
>NZ_CP012475.1|WP_035203501.1|2598258_2598792_+|HXXEE-domain-containing-protein
MIEALNQSVSISSLIWLFLVFFMIHDFEEIIFVEGWVKKRYESVYQRIPSFYRPIFRIFNGMTGSQFAFAVFIEFIVFIPVTYLAAEQQMFTWFIGFNVIAFLHVFTHAGQALLLRMYTPGVITAIIVTLPYSLYLFYRLEAEYNIQVNDLIASIPYGLTIIPIVAFGHLLAKKVIR
>NZ_CP012475.1|WP_035203498.1|2599623_2600568_-|hypothetical-protein
MIHILCANPALDRTIYVQAFYPNGVTRSSASHEGLGGKGFNVALPFIVTNEQKTIHMHTFFGGPVGEQLAQMMKNAQLAGETTFIEGDNRYCTILVNESKQEAALINEQGPSITEKEQQQFLQSLFCSLKAGDHLVLSGSLPKGTPLTFYRDIIAQAESRGVQTILDSSGDALAYGAEAKPWLIKINGEEFLDLMGVKEEAANRQQQIEEYLKNSPYPNCIVTLGGEGTVAKINGDIWRVTLPTINVTNATASGDIFLGTFIREWRKTNDVKAALLAGSALSLANCLHWLPTIDFSQAEQYQQKIHIERIGSAV
>NZ_CP012475.1|WP_011248411.1|2600750_2601539_+|DeoR/GlpR-transcriptional-regulator
MLPQERQDLIMKELYEYHSVKISELSSKLDVTRETIRKDLYELEEKGLIRKVHGGAVLNKANLETNYSSRKIVNEWEKRAIAKKAVEFVFDNDTIYIDYGTTALYFARELIMKKTGLTIVTNSLSLANELVEHSNFSIIIIGGNVRKNERSLYGPVANQTIANLYVDTGFFGIGALHPEVGYTNIHMGEAEVSRLMVQHSKRRVMMADYSKFGSIHMNKVAPIEEVDTLITDSKADAEMLKAIQAKARNVIVVEAEGGEGDE
>NZ_CP012475.1|WP_011248410.1|2601531_2602011_+|PTS-sugar-transporter-subunit-IIA
MSNALLDRDLILLNQTCQTVEEVLETIAAPMQAKQFAKETYADGLKEREQSFATGIPTEPFGVAIPHTDASYVLESKIGLLTLKEPVSFGVMGSENDQIDVKVVLLLGLADGSAHLKALQTIVERIQDAHFVKKLASVQEKDEALALLDASITKQLEGE

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Crispr_ID: NZ_CP012475_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_8

2599073-2599437

Orphan

I-C

Consensus_repeat	Method
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	PILER-CR
GTCGCACTCTTTGTGAGTGCGTGGATTGAAATA	CRISPRCasFinder
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CRT

5 spacers

The CRISPR arrays of NZ_CP012475_8

>merge|NZ_CP012475|8|2599073-2599437|PILER-CR,CRISPRCasFinder,CRT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAATACACACAGCCCATTGTCTCTTCGTTTCACAGCTTCGTCGCACTCTTTGTGAGTGCGTGGATTGAAATAATCACCTAATTTCTGTTGCCTTATAATCTCTTGGTCGCACTCTTTGTGAGTGCGTGGATTGAAATAACCATGTGTTTGTAATCGGCAGAACTAATACCGGTCGCACTCTTTGTGAGTGCGTGGATTGAAATCGTCCGGGGCATATAAATTGAATTCTTGGACTAGGGTCGCACTCTTCGTGAGTGCGTGGATTGAAATTTGCATTTCCCGTAAACGGGCAAAAAAAGGCGGCGTCGCACTCTTTGTGAGTGCGTGGATTGAAATC

>NZ_CP012475|8|6|2599073-2599436|PILER-CR
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	ACACACAGCCCATTGTCTCTTCGTTTCACAGCTTC
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	AATCACCTAATTTCTGTTGCCTTATAATCTCTTG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	AACCATGTGTTTGTAATCGGCAGAACTAATACCG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CGTCCGGGGCATATAAATTGAATTCTTGGACTAGG
GTCGCACTCTTCGTGAGTGCGTGGATTGAAAT	TTGCATTTCCCGTAAACGGGCAAAAAAAGGCGGC
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT

>NZ_CP012475|8|8|2599073-2599437|CRISPRCasFinder
GTCGCACTCTTTGTGAGTGCGTGGATTGAAATA	CACACAGCCCATTGTCTCTTCGTTTCACAGCTTC
GTCGCACTCTTTGTGAGTGCGTGGATTGAAATA	ATCACCTAATTTCTGTTGCCTTATAATCTCTTG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAATA	ACCATGTGTTTGTAATCGGCAGAACTAATACCG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAATC	GTCCGGGGCATATAAATTGAATTCTTGGACTAGG
GTCGCACTCTTCGTGAGTGCGTGGATTGAAATT	TGCATTTCCCGTAAACGGGCAAAAAAAGGCGGC
GTCGCACTCTTTGTGAGTGCGTGGATTGAAATC

>NZ_CP012475|8|6|2599073-2599436|CRT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	ACACACAGCCCATTGTCTCTTCGTTTCACAGCTTC
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	AATCACCTAATTTCTGTTGCCTTATAATCTCTTG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	AACCATGTGTTTGTAATCGGCAGAACTAATACCG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CGTCCGGGGCATATAAATTGAATTCTTGGACTAGG
GTCGCACTCTTCGTGAGTGCGTGGATTGAAAT	TTGCATTTCCCGTAAACGGGCAAAAAAAGGCGGC
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_011248409.1\|2602013_2602289_+\|PTS-galactitol-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NZ_CP012475.1\|WP_035203486.1\|2608441_2608918_+\|DUF2975-domain-containing-protein	unknown	unknown	gnl\|CDD\|378586
NZ_CP012475.1\|WP_035203504.1\|2597493_2598228_+\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|378155
NZ_CP012475.1\|WP_035203498.1\|2599623_2600568_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238570
NZ_CP012475.1\|WP_035203489.1\|2606676_2607777_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376220
NZ_CP012475.1\|WP_035203510.1\|2595384_2596152_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP012475.1\|WP_035203519.1\|2589778_2591143_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_CP012475.1\|WP_035203516.1\|2592301_2593627_-\|6-phospho-alpha-glucosidase	unknown	unknown	gnl\|CDD\|133434
NZ_CP012475.1\|WP_035203521.1\|2588918_2589752_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP012475.1\|WP_035203501.1\|2598258_2598792_+\|HXXEE-domain-containing-protein	unknown	unknown	gnl\|CDD\|379370
NZ_CP012475.1\|WP_035203492.1\|2604740_2605610_+\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|376459
NZ_CP012475.1\|WP_035203507.1\|2596951_2597425_+\|DUF5381-family-protein	unknown	unknown	gnl\|CDD\|375146
NZ_CP012475.1\|WP_011248408.1\|2602314_2603661_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CP012475.1\|WP_035203494.1\|2603681_2604740_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_CP012475.1\|WP_011248416.1\|2596270_2596756_+\|DUF1648-domain-containing-protein	unknown	unknown	gnl\|CDD\|377929
NZ_CP012475.1\|WP_035203484.1\|2608928_2609153_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226181
NZ_CP012475.1\|WP_011248410.1\|2601531_2602011_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NZ_CP012475.1\|WP_011248411.1\|2600750_2601539_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP012475.1\|WP_035203522.1\|2587999_2588929_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP012475.1\|WP_035203513.1\|2593656_2595240_-\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273925

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_011248409.1\|2602013_2602289_+\|PTS-galactitol-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	1.29288e-38
NZ_CP012475.1\|WP_035203486.1\|2608441_2608918_+\|DUF2975-domain-containing-protein	gnl\|CDD\|378586	pfam11188, DUF2975, Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	8.94473e-34
NZ_CP012475.1\|WP_035203504.1\|2597493_2598228_+\|SMI1/KNR4-family-protein	gnl\|CDD\|378155	pfam09346, SMI1_KNR4, SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.	9.06235e-06
NZ_CP012475.1\|WP_035203498.1\|2599623_2600568_-\|hypothetical-protein	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	4.17429e-65
NZ_CP012475.1\|WP_035203489.1\|2606676_2607777_-\|hypothetical-protein	gnl\|CDD\|376220	pfam18801, RapH_N, response regulator aspartate phosphatase H, N terminal. Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.	7.37604e-20
NZ_CP012475.1\|WP_035203510.1\|2595384_2596152_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	4.54204e-36
NZ_CP012475.1\|WP_035203519.1\|2589778_2591143_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	2.08068e-149
NZ_CP012475.1\|WP_035203516.1\|2592301_2593627_-\|6-phospho-alpha-glucosidase	gnl\|CDD\|133434	cd05298, GH4_GlvA_pagL_like, Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases. Bacillus subtilis GlvA and Clostridium acetobutylicum pagL are 6-phospho-alpha-glucosidase, catalyzing the hydrolysis of alpha-glucopyranoside bonds to release glucose from oligosaccharides. The substrate specificities of other members of this subgroup are unknown. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP_PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases, which include 6-phospho-beta-glucosidases, 6-phospho-alpha-glucosidases, alpha-glucosidases/alpha-glucuronidases (only from Thermotoga), and alpha-galactosidases. Members of this subfamily are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CP012475.1\|WP_035203521.1\|2588918_2589752_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.94029e-90
NZ_CP012475.1\|WP_035203501.1\|2598258_2598792_+\|HXXEE-domain-containing-protein	gnl\|CDD\|379370	pfam13787, HXXEE, Protein of unknown function with HXXEE motif. This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.	6.0163e-17
NZ_CP012475.1\|WP_035203492.1\|2604740_2605610_+\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|376459	pfam01116, F_bP_aldolase, Fructose-bisphosphate aldolase class-II.	2.23495e-129
NZ_CP012475.1\|WP_035203507.1\|2596951_2597425_+\|DUF5381-family-protein	gnl\|CDD\|375146	pfam17353, DUF5381, Family of unknown function (DUF5381). This is a family of unknown function found in Bacillales.	0.00423398
NZ_CP012475.1\|WP_011248408.1\|2602314_2603661_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	4.91628e-164
NZ_CP012475.1\|WP_035203494.1\|2603681_2604740_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	2.32129e-165
NZ_CP012475.1\|WP_011248416.1\|2596270_2596756_+\|DUF1648-domain-containing-protein	gnl\|CDD\|377929	pfam07853, DUF1648, Protein of unknown function (DUF1648). Members of this family are hypothetical proteins expressed by either bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues.	0.00239141
NZ_CP012475.1\|WP_035203484.1\|2608928_2609153_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|226181	COG3655, COG3655, Predicted transcriptional regulator [Transcription].	1.58556e-29
NZ_CP012475.1\|WP_011248410.1\|2601531_2602011_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	2.57201e-35
NZ_CP012475.1\|WP_011248411.1\|2600750_2601539_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	4.3258e-90
NZ_CP012475.1\|WP_035203522.1\|2587999_2588929_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.36599e-94
NZ_CP012475.1\|WP_035203513.1\|2593656_2595240_-\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273925	TIGR02005, PTS-IIBC-alpha, PTS system, alpha-glucoside-specific IIBC component. This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0

>NZ_CP012475.1|WP_035203501.1|2598258_2598792_+|HXXEE-domain-containing-protein
MIEALNQSVSISSLIWLFLVFFMIHDFEEIIFVEGWVKKRYESVYQRIPSFYRPIFRIFNGMTGSQFAFAVFIEFIVFIPVTYLAAEQQMFTWFIGFNVIAFLHVFTHAGQALLLRMYTPGVITAIIVTLPYSLYLFYRLEAEYNIQVNDLIASIPYGLTIIPIVAFGHLLAKKVIR
>NZ_CP012475.1|WP_035203504.1|2597493_2598228_+|SMI1/KNR4-family-protein
MEASIEGLLRLLRDQHEAHHGIPESEIEAKERELGFSLPLVLRNYYKALGRSPHISQGCNNQYEPLPLEKLFIPDSTFFTTDKAFLVFYQVEESVIYCGIRLDELEKEDPPVYLCAWSFADWQLENQSLSRFLAGKALVQLGVEDRLPYWAIFDESTGNLSDYHEWMRLDDHEDEIEEGSELNTWKIFVKDDVLIVFELSGSEEEEAPLAVYLASFKRTNLENLLNELEKAANLPAYRTNLFEQ
>NZ_CP012475.1|WP_035203507.1|2596951_2597425_+|DUF5381-family-protein
MKAISYRKSVAWGKALGSLLFVLVCLFLLYVAFFTDATLIHTFFCITSAIIGIPFFGGYLVVCLPRALKSNTQLLTYDQQAISDGKQTVAWVDIVKISYSGPSIQRWLLPQFPKLIFHLKNRETWTVNTYYLLTDTEIQSVMKLLHGLIGRNGKEIK
>NZ_CP012475.1|WP_011248416.1|2596270_2596756_+|DUF1648-domain-containing-protein
MEKPKNGHSKIENLLVFLSAVFFIYHLTFLINAWPDIPNQIAFHYSNGIPDNFRPKYLLIVIPLIGVLMWCLLGFLVRKPEKLNYINLTEANKDLQYMKARKIMSVVQNASFIMLLFANEAFIRGAMGLEFSFQLSISLLLLVICNLTPLYFLIWAFRLKY
>NZ_CP012475.1|WP_035203510.1|2595384_2596152_+|MurR/RpiR-family-transcriptional-regulator
MILDKLVNKHFESLSENDLHIIKTIYDHIDEMKTMKIQDLAVYAHTSISSIHRLTKKIGLDGYSDLKSYIKLNNFTEGTSQDLMELLDQDIHQTRKYMEQLDFCQLNRLIDRAPYIYIYGTGAAQLDLANDVQRQLWTLHKKSQVIRSERDFTNGLGEMGENDLLFIISLSGESENLDEIIHAIKTRKIKCVSLTTLRNNLLAQNAMFNIYVNSTPFWLYNKVENSSFLPFYIVVDIIVRKFSEWKMEQLKNNMT
>NZ_CP012475.1|WP_035203513.1|2593656_2595240_-|PTS-transporter-subunit-EIIC
MNAIKRFGSAMIVPVLLFAFFGIVVGLATLFKNPAIMGDIAAEGTMWYKVWSLIESGGWTIFNHMELAFVIGLPISLAKKAQARATLAALMVYLVFNNFINAILTLWPSTFGVDLSQGVENITGVKEIAGIPTLDTNIIGAIVISAIVIWIHNRFYDQKLPEMLGIFQGLVFVVIIGFFVMIPFAFLVAFVWPYVQQGIGSLQGFISQAGYVGVWLFHFLERVLIPTGLHHFIYTPFEFGPAAVNEGLKPYWIANLNDFATSTSALKDLYPYGFLLHGNIKMFGCLGIALAMYYSTPKENRKKVLALVLPATLTAIFAGITEPLEFTFLFIAPYLFVIHALLGATMVTLMNMFGVVGMMGGGLIEIVALNWIPLASNHGSIYIVQAMIGLIFAALYFVLFRWMIVKFDIPLPGRKKEEEARLYTKQDYQKAKKGSNHEKEAAAAYESEYEEKAVYYLEGLGGKENIKDVTNCATRLRVTVIDPSLVKDSDYFTNNKMAHGVAKSGQSIQIIVGLSVPQVRDSFETKL
>NZ_CP012475.1|WP_035203516.1|2592301_2593627_-|6-phospho-alpha-glucosidase
MKTFNITIAGGGSTFTPGIILMLLDYLDEFPIDTIKLYDNDGDRQKTIADACAILLKERAPQVRLLASTNPEEAFTNVDFVMAHIRVGKYAMRELDEKIPLKHGVVGQETCGPGGIAYGMRSIPGVLELIDYMEKYSPEAWMLNYSNPAAIVAEATRKLRPHSKVLNICDMPIGIEELIAKNLGFASRKEMEVDYYGLNHFGWWTDIRDKNGNSLMPDVIKHVSQHGYATDGTSELEQQESWNSTLKKAREVQALDPKTVPNTYLKYYLYPDYEVAHSNKEYTRANEVMEGREKFVFGECQAIIDKGTAKETKLVIDEHASYIVDLAKAIAFNTKERMLMIVENNGAIPNFDPTAMVEIPCIVGSNGPEKLVVGEIPRFQKSLMEQQVGVEKLVVEAFEEGSYQKLWQAITLSKTVPSAKVAKDILDDLIEANKAFWPALK
>NZ_CP012475.1|WP_035203519.1|2589778_2591143_+|FAD-dependent-oxidoreductase
MRQVTEIEKQVRVRAEADVVVCGGGPAGIGAALSAARNGAKTILLESHGFLGGMGTAGMVTSFAYGYHDKERFITGGIFQEIRQKLHDRGGLIMTDRKGWEPFNAEQYKILAFELLAEAGVELLCHTTVVNTITKEGTIEAIIIESKAGREALLATHVIDATGDGDVAERAGAICKIGRDKDGGTQPSSLMYVLGNVDTAALGEMLDQEGRRGYWKTEDGYRYVNATGFADEIEQAKRDGFLTKVNRDHIAAIFTVPWIDNVVGINFGRIQGKNALDPQDLTDAEVIGREQVLDGIAFLKEYVPGFKRAELLQTAPQVGIRETRRIIGDYVITQEDIVELKQFDDCIAQSCYMIDIHSPDSSTTEIYKLPKGTHYDIPYRALLPQGLNNLLVAGRCISATHEALGSFRVQAICLAIGEAAGAAAAIATKEKCLPREIDVKHLQDTLVNQGAILS
>NZ_CP012475.1|WP_035203521.1|2588918_2589752_+|carbohydrate-ABC-transporter-permease
MKINSVSTVVRYGLLTIISAIMLLPFIWMVTTSLKDPNQIFALPPTFIPNPIQWDSYINVLSSTHFLRQMFNSIYIGAAVTIGTVLLASLAGYAFARIPFKGRNVVFLAFLSVMMIPGEVTIIPLFLFMRELGWIDTHLPLMIIPIFGAGGAFGIFVMRQFFKQVPAELEDAARIDGCSRFRIFVQIMLPLSKPALATVTIFTFLTNWNEFLEPLIFINSRELMTLPLALSLFTDEAGTDWSSLMSASVLATLPVLIVFFFAQKQFIESLAMSGSKE
>NZ_CP012475.1|WP_035203522.1|2587999_2588929_+|sugar-ABC-transporter-permease
MNADVQAEWRQKKKRPRKPIFKRDELAGWLFISPMLLGFTIFMFVPIGFAFYMSFTDWPLLGQSEFIGTANYQAIVQDPEFQQVMKNTVLFTAGLVPFNIILALGLALLLRHPLPGMGLFRTIVFVPVVTTLVVWAIVWRYMFATDFGFINSILAWFGIEPQAWLYNKNLAMPVVILTSVLKNVGLNMVLFLAALQMVPKNLYEAARIDGAGSWRQFKNITLPIISPTVFLATIITIIGAMKIFAQIFVMTKGGPESSTKVIVYYIWEKAFRLFDMGYASAAAFILFFVIFAFTLIQWWLRKRWVYNED
>NZ_CP012475.1|WP_035203498.1|2599623_2600568_-|hypothetical-protein
MIHILCANPALDRTIYVQAFYPNGVTRSSASHEGLGGKGFNVALPFIVTNEQKTIHMHTFFGGPVGEQLAQMMKNAQLAGETTFIEGDNRYCTILVNESKQEAALINEQGPSITEKEQQQFLQSLFCSLKAGDHLVLSGSLPKGTPLTFYRDIIAQAESRGVQTILDSSGDALAYGAEAKPWLIKINGEEFLDLMGVKEEAANRQQQIEEYLKNSPYPNCIVTLGGEGTVAKINGDIWRVTLPTINVTNATASGDIFLGTFIREWRKTNDVKAALLAGSALSLANCLHWLPTIDFSQAEQYQQKIHIERIGSAV
>NZ_CP012475.1|WP_011248411.1|2600750_2601539_+|DeoR/GlpR-transcriptional-regulator
MLPQERQDLIMKELYEYHSVKISELSSKLDVTRETIRKDLYELEEKGLIRKVHGGAVLNKANLETNYSSRKIVNEWEKRAIAKKAVEFVFDNDTIYIDYGTTALYFARELIMKKTGLTIVTNSLSLANELVEHSNFSIIIIGGNVRKNERSLYGPVANQTIANLYVDTGFFGIGALHPEVGYTNIHMGEAEVSRLMVQHSKRRVMMADYSKFGSIHMNKVAPIEEVDTLITDSKADAEMLKAIQAKARNVIVVEAEGGEGDE
>NZ_CP012475.1|WP_011248410.1|2601531_2602011_+|PTS-sugar-transporter-subunit-IIA
MSNALLDRDLILLNQTCQTVEEVLETIAAPMQAKQFAKETYADGLKEREQSFATGIPTEPFGVAIPHTDASYVLESKIGLLTLKEPVSFGVMGSENDQIDVKVVLLLGLADGSAHLKALQTIVERIQDAHFVKKLASVQEKDEALALLDASITKQLEGE
>NZ_CP012475.1|WP_011248409.1|2602013_2602289_+|PTS-galactitol-transporter-subunit-IIB
MKKVLVACGGAVATSTVAANKVKAILKENNIQADVSQCRVSELGSKAQGADLIISTAKVDRDYGVPVIHGLPFISGVGLDKTKQEILDILK
>NZ_CP012475.1|WP_011248408.1|2602314_2603661_+|PTS-galactitol-transporter-subunit-IIC
MNVLQYILDLGPAVMLPAVIFVLGLLLRQGIGKSLRSGITIGVGFVGITLVISLLTDNLGPAAQEMAERFNLGLSIVDVGWPGASPMAWASNIGTVAIPVAILVNVVMLLLKWTRVVNVDIWNIWHMAFAGAIVSTASGSFWLGVLGVVIYAAFAYKLGDWFAPIIHKYNGLEGISIPHGTGAIMAPIAVVTDAIIEKIPGLKNVNINSDKIENRLGPIGEPAIIGAILGTVIGALAGYEVSAILQLGIQMAAVMLLMPTVVKFIMEGLMPIAEAAREMLDKRFSGQDYYIGLDPALLLGNSQVVAASLIFVPLTLVIAILIPGNEVLPFGDLATIGFFISIAVGIHGGNLFRTLISGTLIMTMTIWIANMMVGVHTQLALNTGTISGGQVASLDQGGSPLQFIMTELTTWQNLLPLIVVTAIYGFCVVFTIVQHKRGKLLPAETDKN
>NZ_CP012475.1|WP_035203494.1|2603681_2604740_+|galactitol-1-phosphate-5-dehydrogenase
MKALVLEANQSFTIKDIETPVPKEDEALIKVAYCGICGSDLARYFDGKVHNYPIVLGHEFSGTVEAVGASVDSVTVGDRVVVAPLLPNKDDPFMQKGSPALSSSYSFLGSRENGAMAEYVVVKAENLLVLPETVTLAEAALIEPLTVAIHGIERIVLPAGEHVCVLGAGTIGIMTILALKARGAGKVTAIDINDEKLAFAKKIGADDTINSLKEDPVSYASKHGKPGAVIETAGVPSAQEQAVALVEKKGKIVFVGTASGDVTFPAATFEKILREELEITGSWMSYSGPFPGYEWQAAIDYIASGKIDVKPLIHDVFKLEDGDKPFQAMKDPDNHSIKLLYQIAENEGQVGK
>NZ_CP012475.1|WP_035203492.1|2604740_2605610_+|class-II-fructose-bisphosphate-aldolase
MGLQSTTPMLKKAKANKHGIVAFNVHSFDSIFWVLEAAAELKSPVILQTTVGTVKSLGAKNIAEVAKAAAEHYQVPTGLHLDHCTDFEVIKDAIRAGYTSVMMDASMHPFAENVARTKEVVALASSLGVNVEAELGKVGGVEDDIVVDEADAQKAIPEECRQFVEETDVPTLAPAIGTAHGIYKGKPEIDFERIAKIAEMVDVPLVLHGGSAVPEEDVRRCVALGMAKVNVSTELKNAYSEAIRDHFANEPDSLDPRAYLQKAKEAAKEMAKSKIRMVGSENTVVPAFA
>NZ_CP012475.1|WP_035203489.1|2606676_2607777_-|hypothetical-protein
MSAILSPEEVSTIIAEWYSCIIARSVEQANELKEKAENMVKTMEPNDRVIAYYSLVEFRHSIMAKQGGKDEKDDERIQQAGNMIEDSIDHTLKYLYLFVSGQNEFIKERYQSAIRLFRKAERLLEYINDEAEEAEFYYYMGSSLYRINQYPYAASYIEEALLAFNRLGYIERAVYCQVILGGIYSEAGQHEKVRKLLEEALSISNNYPMAQVAVLRIIGLDALRKKAYQKAKEYFEKSLSYPECTETILGVKSEYNLANALFRIGLFNEALPHLTKAYAGAQSYNNHEYQARCIATYGLYVNSNPEEIDQAIKSLSESDMNFEIEEIAEEAATFFKQKGEQELAWKYLNVAYRARQNLSNIGVDQP
>NZ_CP012475.1|WP_035203486.1|2608441_2608918_+|DUF2975-domain-containing-protein
MKRGSTLFLKIAVVLMGSPVLALCIFGLAWIPNHPVDPDYGHILYPIFIGVFLTVIPFFVALSQAFKLLSYIDKNQSFSELSTRALKKIKYCAIIISGLYVAIMPFFYLLADRDDAPGLLFMGVVPLFASTVIAVFAAVLQRLFQEAIDIKSENDLTV
>NZ_CP012475.1|WP_035203484.1|2608928_2609153_+|helix-turn-helix-transcriptional-regulator
MAIIINVDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIRLSTLDAICKALDCQPGDLLEYRSDENLHDE

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Crispr_ID: NZ_CP012475_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_9

2606024-2606322

Orphan

I-C

Consensus_repeat	Method
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATT	PILER-CR
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATT	CRT

4 spacers

The CRISPR arrays of NZ_CP012475_9

>merge|NZ_CP012475|9|2606024-2606322|PILER-CR,CRISPRCasFinder,CRT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATCCATCTTACAATTACCGCGTTTCTTTTGTTGGACGGTCGCACTCTTAGTGAGTGCGTGGATTGAAATTACCAGTATTCAAACATAGTGCCATCACGAACAATTGTCGCACTCTTAGTGAGTGCGTGGATTGAAATTCGAACAGTTGTTACATCAAAACGGTGTGGAGCGTCGCACTCTTAGTGAGTGCGTGGATTGAAATTCGCGTTGCTCTTGTCTACAATTTGCCGCCTCATGTCGCACTCTTAGTGAGTGCGTGGATTGAAATT

>NZ_CP012475|9|7|2606024-2606322|PILER-CR
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATC	CATCTTACAATTACCGCGTTTCTTTTGTTGGACG
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATT	ACCAGTATTCAAACATAGTGCCATCACGAACAATT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATT	CGAACAGTTGTTACATCAAAACGGTGTGGAGC
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATT	CGCGTTGCTCTTGTCTACAATTTGCCGCCTCAT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATT

>NZ_CP012475|9|9|2606024-2606321|CRISPRCasFinder
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	CCATCTTACAATTACCGCGTTTCTTTTGTTGGACG
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	TACCAGTATTCAAACATAGTGCCATCACGAACAATT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	TCGAACAGTTGTTACATCAAAACGGTGTGGAGC
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	TCGCGTTGCTCTTGTCTACAATTTGCCGCCTCAT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT

>NZ_CP012475|9|7|2606024-2606322|CRT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATC	CATCTTACAATTACCGCGTTTCTTTTGTTGGACG
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATT	ACCAGTATTCAAACATAGTGCCATCACGAACAATT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATT	CGAACAGTTGTTACATCAAAACGGTGTGGAGC
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATT	CGCGTTGCTCTTGTCTACAATTTGCCGCCTCAT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_011248409.1\|2602013_2602289_+\|PTS-galactitol-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NZ_CP012475.1\|WP_035203479.1\|2615491_2616391_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP012475.1\|WP_035203494.1\|2603681_2604740_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_CP012475.1\|WP_035203498.1\|2599623_2600568_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238570
NZ_CP012475.1\|WP_035203477.1\|2620139_2620373_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035203507.1\|2596951_2597425_+\|DUF5381-family-protein	unknown	unknown	gnl\|CDD\|375146
NZ_CP012475.1\|WP_035203481.1\|2611576_2614177_-\|phosphoenolpyruvate-synthase	unknown	unknown	gnl\|CDD\|235751
NZ_CP012475.1\|WP_011248411.1\|2600750_2601539_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP012475.1\|WP_035203504.1\|2597493_2598228_+\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|378155
NZ_CP012475.1\|WP_035203501.1\|2598258_2598792_+\|HXXEE-domain-containing-protein	unknown	unknown	gnl\|CDD\|379370
NZ_CP012475.1\|WP_035203492.1\|2604740_2605610_+\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|376459
NZ_CP012475.1\|WP_035203489.1\|2606676_2607777_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376220
NZ_CP012475.1\|WP_011248408.1\|2602314_2603661_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CP012475.1\|WP_035203486.1\|2608441_2608918_+\|DUF2975-domain-containing-protein	unknown	unknown	gnl\|CDD\|378586
NZ_CP012475.1\|WP_051881192.1\|2616533_2617316_+\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_CP012475.1\|WP_035203484.1\|2608928_2609153_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226181
NZ_CP012475.1\|WP_051881182.1\|2617498_2619202_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NZ_CP012475.1\|WP_011248410.1\|2601531_2602011_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NZ_CP012475.1\|WP_035203478.1\|2619189_2619924_+\|response-regulator	unknown	unknown	gnl\|CDD\|227095
NZ_CP012475.1\|WP_035203482.1\|2609197_2609989_+\|DUF817-domain-containing-protein	unknown	unknown	gnl\|CDD\|226262

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_011248409.1\|2602013_2602289_+\|PTS-galactitol-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	1.29288e-38
NZ_CP012475.1\|WP_035203479.1\|2615491_2616391_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.04281e-49
NZ_CP012475.1\|WP_035203494.1\|2603681_2604740_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	2.32129e-165
NZ_CP012475.1\|WP_035203498.1\|2599623_2600568_-\|hypothetical-protein	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	4.17429e-65
NZ_CP012475.1\|WP_035203507.1\|2596951_2597425_+\|DUF5381-family-protein	gnl\|CDD\|375146	pfam17353, DUF5381, Family of unknown function (DUF5381). This is a family of unknown function found in Bacillales.	0.00423398
NZ_CP012475.1\|WP_035203481.1\|2611576_2614177_-\|phosphoenolpyruvate-synthase	gnl\|CDD\|235751	PRK06241, PRK06241, phosphoenolpyruvate synthase; Validated.	0
NZ_CP012475.1\|WP_011248411.1\|2600750_2601539_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	4.3258e-90
NZ_CP012475.1\|WP_035203504.1\|2597493_2598228_+\|SMI1/KNR4-family-protein	gnl\|CDD\|378155	pfam09346, SMI1_KNR4, SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.	9.06235e-06
NZ_CP012475.1\|WP_035203501.1\|2598258_2598792_+\|HXXEE-domain-containing-protein	gnl\|CDD\|379370	pfam13787, HXXEE, Protein of unknown function with HXXEE motif. This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.	6.0163e-17
NZ_CP012475.1\|WP_035203492.1\|2604740_2605610_+\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|376459	pfam01116, F_bP_aldolase, Fructose-bisphosphate aldolase class-II.	2.23495e-129
NZ_CP012475.1\|WP_035203489.1\|2606676_2607777_-\|hypothetical-protein	gnl\|CDD\|376220	pfam18801, RapH_N, response regulator aspartate phosphatase H, N terminal. Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.	7.37604e-20
NZ_CP012475.1\|WP_011248408.1\|2602314_2603661_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	4.91628e-164
NZ_CP012475.1\|WP_035203486.1\|2608441_2608918_+\|DUF2975-domain-containing-protein	gnl\|CDD\|378586	pfam11188, DUF2975, Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	8.94473e-34
NZ_CP012475.1\|WP_051881192.1\|2616533_2617316_+\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.10498e-19
NZ_CP012475.1\|WP_035203484.1\|2608928_2609153_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|226181	COG3655, COG3655, Predicted transcriptional regulator [Transcription].	1.58556e-29
NZ_CP012475.1\|WP_051881182.1\|2617498_2619202_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	2.87735e-55
NZ_CP012475.1\|WP_011248410.1\|2601531_2602011_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	2.57201e-35
NZ_CP012475.1\|WP_035203478.1\|2619189_2619924_+\|response-regulator	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	3.8685e-51
NZ_CP012475.1\|WP_035203482.1\|2609197_2609989_+\|DUF817-domain-containing-protein	gnl\|CDD\|226262	COG3739, COG3739, Uncharacterized integral membrane protein [Function unknown].	1.70048e-129

>NZ_CP012475.1|WP_035203492.1|2604740_2605610_+|class-II-fructose-bisphosphate-aldolase
MGLQSTTPMLKKAKANKHGIVAFNVHSFDSIFWVLEAAAELKSPVILQTTVGTVKSLGAKNIAEVAKAAAEHYQVPTGLHLDHCTDFEVIKDAIRAGYTSVMMDASMHPFAENVARTKEVVALASSLGVNVEAELGKVGGVEDDIVVDEADAQKAIPEECRQFVEETDVPTLAPAIGTAHGIYKGKPEIDFERIAKIAEMVDVPLVLHGGSAVPEEDVRRCVALGMAKVNVSTELKNAYSEAIRDHFANEPDSLDPRAYLQKAKEAAKEMAKSKIRMVGSENTVVPAFA
>NZ_CP012475.1|WP_035203494.1|2603681_2604740_+|galactitol-1-phosphate-5-dehydrogenase
MKALVLEANQSFTIKDIETPVPKEDEALIKVAYCGICGSDLARYFDGKVHNYPIVLGHEFSGTVEAVGASVDSVTVGDRVVVAPLLPNKDDPFMQKGSPALSSSYSFLGSRENGAMAEYVVVKAENLLVLPETVTLAEAALIEPLTVAIHGIERIVLPAGEHVCVLGAGTIGIMTILALKARGAGKVTAIDINDEKLAFAKKIGADDTINSLKEDPVSYASKHGKPGAVIETAGVPSAQEQAVALVEKKGKIVFVGTASGDVTFPAATFEKILREELEITGSWMSYSGPFPGYEWQAAIDYIASGKIDVKPLIHDVFKLEDGDKPFQAMKDPDNHSIKLLYQIAENEGQVGK
>NZ_CP012475.1|WP_011248408.1|2602314_2603661_+|PTS-galactitol-transporter-subunit-IIC
MNVLQYILDLGPAVMLPAVIFVLGLLLRQGIGKSLRSGITIGVGFVGITLVISLLTDNLGPAAQEMAERFNLGLSIVDVGWPGASPMAWASNIGTVAIPVAILVNVVMLLLKWTRVVNVDIWNIWHMAFAGAIVSTASGSFWLGVLGVVIYAAFAYKLGDWFAPIIHKYNGLEGISIPHGTGAIMAPIAVVTDAIIEKIPGLKNVNINSDKIENRLGPIGEPAIIGAILGTVIGALAGYEVSAILQLGIQMAAVMLLMPTVVKFIMEGLMPIAEAAREMLDKRFSGQDYYIGLDPALLLGNSQVVAASLIFVPLTLVIAILIPGNEVLPFGDLATIGFFISIAVGIHGGNLFRTLISGTLIMTMTIWIANMMVGVHTQLALNTGTISGGQVASLDQGGSPLQFIMTELTTWQNLLPLIVVTAIYGFCVVFTIVQHKRGKLLPAETDKN
>NZ_CP012475.1|WP_011248409.1|2602013_2602289_+|PTS-galactitol-transporter-subunit-IIB
MKKVLVACGGAVATSTVAANKVKAILKENNIQADVSQCRVSELGSKAQGADLIISTAKVDRDYGVPVIHGLPFISGVGLDKTKQEILDILK
>NZ_CP012475.1|WP_011248410.1|2601531_2602011_+|PTS-sugar-transporter-subunit-IIA
MSNALLDRDLILLNQTCQTVEEVLETIAAPMQAKQFAKETYADGLKEREQSFATGIPTEPFGVAIPHTDASYVLESKIGLLTLKEPVSFGVMGSENDQIDVKVVLLLGLADGSAHLKALQTIVERIQDAHFVKKLASVQEKDEALALLDASITKQLEGE
>NZ_CP012475.1|WP_011248411.1|2600750_2601539_+|DeoR/GlpR-transcriptional-regulator
MLPQERQDLIMKELYEYHSVKISELSSKLDVTRETIRKDLYELEEKGLIRKVHGGAVLNKANLETNYSSRKIVNEWEKRAIAKKAVEFVFDNDTIYIDYGTTALYFARELIMKKTGLTIVTNSLSLANELVEHSNFSIIIIGGNVRKNERSLYGPVANQTIANLYVDTGFFGIGALHPEVGYTNIHMGEAEVSRLMVQHSKRRVMMADYSKFGSIHMNKVAPIEEVDTLITDSKADAEMLKAIQAKARNVIVVEAEGGEGDE
>NZ_CP012475.1|WP_035203498.1|2599623_2600568_-|hypothetical-protein
MIHILCANPALDRTIYVQAFYPNGVTRSSASHEGLGGKGFNVALPFIVTNEQKTIHMHTFFGGPVGEQLAQMMKNAQLAGETTFIEGDNRYCTILVNESKQEAALINEQGPSITEKEQQQFLQSLFCSLKAGDHLVLSGSLPKGTPLTFYRDIIAQAESRGVQTILDSSGDALAYGAEAKPWLIKINGEEFLDLMGVKEEAANRQQQIEEYLKNSPYPNCIVTLGGEGTVAKINGDIWRVTLPTINVTNATASGDIFLGTFIREWRKTNDVKAALLAGSALSLANCLHWLPTIDFSQAEQYQQKIHIERIGSAV
>NZ_CP012475.1|WP_035203501.1|2598258_2598792_+|HXXEE-domain-containing-protein
MIEALNQSVSISSLIWLFLVFFMIHDFEEIIFVEGWVKKRYESVYQRIPSFYRPIFRIFNGMTGSQFAFAVFIEFIVFIPVTYLAAEQQMFTWFIGFNVIAFLHVFTHAGQALLLRMYTPGVITAIIVTLPYSLYLFYRLEAEYNIQVNDLIASIPYGLTIIPIVAFGHLLAKKVIR
>NZ_CP012475.1|WP_035203504.1|2597493_2598228_+|SMI1/KNR4-family-protein
MEASIEGLLRLLRDQHEAHHGIPESEIEAKERELGFSLPLVLRNYYKALGRSPHISQGCNNQYEPLPLEKLFIPDSTFFTTDKAFLVFYQVEESVIYCGIRLDELEKEDPPVYLCAWSFADWQLENQSLSRFLAGKALVQLGVEDRLPYWAIFDESTGNLSDYHEWMRLDDHEDEIEEGSELNTWKIFVKDDVLIVFELSGSEEEEAPLAVYLASFKRTNLENLLNELEKAANLPAYRTNLFEQ
>NZ_CP012475.1|WP_035203507.1|2596951_2597425_+|DUF5381-family-protein
MKAISYRKSVAWGKALGSLLFVLVCLFLLYVAFFTDATLIHTFFCITSAIIGIPFFGGYLVVCLPRALKSNTQLLTYDQQAISDGKQTVAWVDIVKISYSGPSIQRWLLPQFPKLIFHLKNRETWTVNTYYLLTDTEIQSVMKLLHGLIGRNGKEIK
>NZ_CP012475.1|WP_035203489.1|2606676_2607777_-|hypothetical-protein
MSAILSPEEVSTIIAEWYSCIIARSVEQANELKEKAENMVKTMEPNDRVIAYYSLVEFRHSIMAKQGGKDEKDDERIQQAGNMIEDSIDHTLKYLYLFVSGQNEFIKERYQSAIRLFRKAERLLEYINDEAEEAEFYYYMGSSLYRINQYPYAASYIEEALLAFNRLGYIERAVYCQVILGGIYSEAGQHEKVRKLLEEALSISNNYPMAQVAVLRIIGLDALRKKAYQKAKEYFEKSLSYPECTETILGVKSEYNLANALFRIGLFNEALPHLTKAYAGAQSYNNHEYQARCIATYGLYVNSNPEEIDQAIKSLSESDMNFEIEEIAEEAATFFKQKGEQELAWKYLNVAYRARQNLSNIGVDQP
>NZ_CP012475.1|WP_035203486.1|2608441_2608918_+|DUF2975-domain-containing-protein
MKRGSTLFLKIAVVLMGSPVLALCIFGLAWIPNHPVDPDYGHILYPIFIGVFLTVIPFFVALSQAFKLLSYIDKNQSFSELSTRALKKIKYCAIIISGLYVAIMPFFYLLADRDDAPGLLFMGVVPLFASTVIAVFAAVLQRLFQEAIDIKSENDLTV
>NZ_CP012475.1|WP_035203484.1|2608928_2609153_+|helix-turn-helix-transcriptional-regulator
MAIIINVDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIRLSTLDAICKALDCQPGDLLEYRSDENLHDE
>NZ_CP012475.1|WP_035203482.1|2609197_2609989_+|DUF817-domain-containing-protein
MRPLKQLVRFGWEQALSCLFPVVIFASLAITQLVPLPFLPRYDWLLIICLFMQWWMVRSGLETWDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKVFGVPLYSGFMYASVASYLCQAWRRLKIELVKWPSLLLVVPLAAAIYLNFITHHFWIDIRFWLAGLVIIVFWPSWVTYEVNETRYRMPLALSFVLIGFFIWIAENIATFFGAWEYPNQTDAWSLVHLGKVSSWLLLVIVSFLIVATLKQVKGKRRTGVDASQSL
>NZ_CP012475.1|WP_035203481.1|2611576_2614177_-|phosphoenolpyruvate-synthase
MSSLVLGFQEMDEKQLLLVGGKGLNLGELSKIQGIQVPEGFCVTTTGFQKAIKQNDTFQALLAQLATLKVEDRDQIGEISRKIRELILEVEIPSDVVKAVAHYLSQFGEKHAYAVRSSATAEDLPHASFAGQQDTFLNIIGKDAILQHISKCWASLFTDRAVIYRMQNGFDHSQVYLSVIVQKMVFPQASGILFTADPMTSNRKVLSIDAGFGLGEALVSGLVSADCYKVREDQIVDKRIATKKLAIYGREEGGTETQQIDPDQQKTQTLTDQQILQLARIGRQIEAHFGQPQDIEWCLANDTFYIVQSRPITTLYPIPETNDQENHVYLSVGHQQMMTDPIKPLGLSFYLLITPAPMRKAGGRLFVDVAPRLTTRAGREALLNTVGSDPLTKSALMTVIEQDYIKLLPTDQSASNPGNSHKGMSEQFETDPTIVSKLIKRSQTSIEQLKQNIQAKSGLDLFDFILEDIEQLKKILFDPQSTAVFMAAINATTWINENMNEWLGEKNAADTLSLSVPHNITSEMGLALMDVADVIRPYPEVIDYLQHAIEDNFLDELVKFDGGQEARNAIDAYLDKYGMRCPGEIDITRTRWSEKPITLVPMILSHINNFEPNEGNRKFEQGRRVALEKEQELINRLKQLPDGEQKAKETKQRIDLIRNFIGYREYPKYGIVSRYFVYKQALLKEAEQLVQAGVIQEKEDIYYLTFEELHEVARTKKTDDQIINKRKDEYKRYEKLTPPRVITSDGEIITGAYKQANLPANAIAGLAVSTGVIEGRASVILNIENADLEDGDILVTSFTDPGWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENATKLIKDGQRIRVNGTDGYVEILNS
>NZ_CP012475.1|WP_035203479.1|2615491_2616391_-|LysR-family-transcriptional-regulator
MNLHALRIFTKVAALKSVTKAADALSISQPAVTIQIRNLEKETGLKLIKTEGRGINLTKEGEFLVKRAESLFNMEQDIENKLIQLKDGELQELHISSTSLPANYLLPTWLAKFKLAYPSVKINLSSGNSYQVVDQLLHYKSDIAFVVKEEWHHPTIQLHHLMDIEFWFIVPTGHKYDGQEVSLHDLMDEPFLVREEGSSTREVLFSLCNLHNVPVPNIGIQFHGLNESIRSVLAGYGAMLAPSLAVKDHIHRNELGKVLVKDIEIKRPVYLCTRKEDAHTIHLSRLIDLINGFTKDDFY
>NZ_CP012475.1|WP_051881192.1|2616533_2617316_+|TSUP-family-transporter
MIISFSFGRSIVDNHLALLVVIGMLSSFIGTLAGGGGLITVPAMMLTGIPIQTSIATNKFSSGIAAMSSVFYLVNRRQLTIQAIVKTVATAFVGGIAGALLTAYISEKTMNVVAFVLLFFALIVTVGSKNWAKGRKGEEVTLSPQSWRPWTPLFIAAYDGGFGPGSSTFGILYYMKKHHTYLKAVQLTRVLILGSCVGGFLVFYQTGFFQWPYAVALAIGSTVGSQVGLLVLPKVPMKLAKGLLLTVTCLLILSIVYKLV
>NZ_CP012475.1|WP_051881182.1|2617498_2619202_+|sensor-histidine-kinase
MFQQLYQLLGLSRFRRKILIIFLLFSIMPILFIGFVSKQLADRSLIETYRERNQAQLVNASKLIDRSLEDIVNIQRLILADRSIRHELVRSNEQVYEGDETIGVDTYRNLQRLLSNYLVDQRYVDSVCLFDAFFRSVCHGGSAEREAQTFQTKKWYLDALNENGGELLFAENVLAEEKDTFSYVKSLRNPEEFKLDRIGLLVVTIDKSLLEDVNTSQESDLIVQSEDYTVLDTRTDGGKSDGVDEASLESENYIFDAYTNSASGWKLYSVISEDKLLGQLNNIGAVTLALGGGMSVLLMIVMIPVSRRLSGPLSQVYESAIQLFGWPPNEQKRGLDELKVIDGTFKRVAFQHKQLNERLMEAKLREKEAELKLLQAQINPHFLYNTLSSIYWLAKMKKQSEIAQMAISLSESFKISLNNGKEHIPLQKELEHIRHYITIQNIRFRGKFQYKEEIDDRLLNVEIIKLLLQPLIENAIIHGLEKKESTGRVLLRAFVEGDTLVFQIKDDGVGMEHTSQAMHGFGLKNVHERIQLYYGGKSGLTIASAVNQGTVVTVRLQLRKGEILCFG
>NZ_CP012475.1|WP_035203478.1|2619189_2619924_+|response-regulator
MLRVIIVDDEPLMVEGMVQMVDWEANGAKVVGTAHSGGEALVLVEKEKPDLIFTDIEMPGMDGLDFLEAIKPISPDSLLFLFSAHTDFHYAKRALKLGVLDYLVKPVTVPMIEDALDRALVQERKLEQKGGGRPEKANHQAIRKALAFIAERYNHDITIEHVAEHIGMNASYFSTLFKKEMGVSYIKYVTKYRMEIAKQLLLMGEKVMDVSEKVGYQSYRHFSETFKKQYQITPSELKTKGRTE
>NZ_CP012475.1|WP_035203477.1|2620139_2620373_-|hypothetical-protein
MKATFIFENGVYVQESPRDGTPVHVLAYLYNLIYQIETNAMVYIGDENDQDTFAEENLHNVKSIVFEFEEQDRFTKE

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Crispr_ID: NZ_CP012475_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_10

2610333-2610765

Orphan

Consensus_repeat	Method
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	PILER-CR
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	CRT

6 spacers

The CRISPR arrays of NZ_CP012475_10

>merge|NZ_CP012475|10|2610333-2610765|PILER-CR,CRISPRCasFinder,CRT
GTCGCACTTTTTGTGAGTGCGTGGATTGAAATCAAAAAGGATCAGCGATGAAGCGTTTTGCCAGATAGTCGCACTTTTTGTGAGTGCGTGGATTGAAATAACTAGCAAGGAAAAATGCAAAATCTCAATTACTGTCGCACTTTTTGTGAGTGCGTGGATTGAAATTGTCTCTGACATTACTACCCCCCTGTTAGCTAGGGTCGCACTTTTTGTGAGTGCGTGGATTGAAATATACGCCCTTGGCGCGGCATGGCGCTTTTTGTTAGTCGCACTCTTTGTGAGTGCGTGGATTGAAATCATTTTAGGAGTTGACGCAGCGAACATCCGTTTATCGTCGCACTCTTTTTATGAGTGCGTGGGATTGAAATCCGTCTACGCACCCAATCACCAGGGTCGCCATCGTCACACTCCTGGCGAGTACGTGGGTTAAATA

>NZ_CP012475|10|8|2610333-2610629|PILER-CR
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	CAAAAAGGATCAGCGATGAAGCGTTTTGCCAGATA
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	AACTAGCAAGGAAAAATGCAAAATCTCAATTACT
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	TGTCTCTGACATTACTACCCCCCTGTTAGCTAGG
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	ATACGCCCTTGGCGCGGCATGGCGCTTTTTGTTA
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT

>NZ_CP012475|10|10|2610333-2610765|CRISPRCasFinder
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	CAAAAAGGATCAGCGATGAAGCGTTTTGCCAGATA
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	AACTAGCAAGGAAAAATGCAAAATCTCAATTACT
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	TGTCTCTGACATTACTACCCCCCTGTTAGCTAGG
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	ATACGCCCTTGGCGCGGCATGGCGCTTTTTGTTA
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CATTTTAGGAGTTGACGCAGCGAACATCCGTTTATCGT
CGCACTCTTTTTATGAGTGCGTGGGATTGAAA	TCCGTCTACGCACCCAATCACCAGGGTCGCCATC
GTCACACTCCTGGCGAGTACGTGGGTTAAATA

>NZ_CP012475|10|8|2610333-2610699|CRT
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	CAAAAAGGATCAGCGATGAAGCGTTTTGCCAGATA
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	AACTAGCAAGGAAAAATGCAAAATCTCAATTACT
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	TGTCTCTGACATTACTACCCCCCTGTTAGCTAGG
GTCGCACTTTTTGTGAGTGCGTGGATTGAAAT	ATACGCCCTTGGCGCGGCATGGCGCTTTTTGTTA
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CATTTTAGGAGTTGACGCAGCGAACATCCGTTTATCGT
CGCACTCTTTTTATGAGTGCGTGGGATTGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_011248409.1\|2602013_2602289_+\|PTS-galactitol-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NZ_CP012475.1\|WP_035203479.1\|2615491_2616391_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP012475.1\|WP_035203494.1\|2603681_2604740_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_CP012475.1\|WP_035203471.1\|2621907_2622792_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP012475.1\|WP_035203481.1\|2611576_2614177_-\|phosphoenolpyruvate-synthase	unknown	unknown	gnl\|CDD\|235751
NZ_CP012475.1\|WP_035203482.1\|2609197_2609989_+\|DUF817-domain-containing-protein	unknown	unknown	gnl\|CDD\|226262
NZ_CP012475.1\|WP_011248410.1\|2601531_2602011_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NZ_CP012475.1\|WP_035203468.1\|2623701_2626344_+\|alpha-L-rhamnosidase	unknown	unknown	gnl\|CDD\|379971
NZ_CP012475.1\|WP_035203492.1\|2604740_2605610_+\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|376459
NZ_CP012475.1\|WP_035203489.1\|2606676_2607777_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376220
NZ_CP012475.1\|WP_011248408.1\|2602314_2603661_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CP012475.1\|WP_035203486.1\|2608441_2608918_+\|DUF2975-domain-containing-protein	unknown	unknown	gnl\|CDD\|378586
NZ_CP012475.1\|WP_035203474.1\|2620571_2621852_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NZ_CP012475.1\|WP_051881192.1\|2616533_2617316_+\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_CP012475.1\|WP_082369160.1\|2622807_2623686_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP012475.1\|WP_035203484.1\|2608928_2609153_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226181
NZ_CP012475.1\|WP_035203477.1\|2620139_2620373_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_051881182.1\|2617498_2619202_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NZ_CP012475.1\|WP_035203478.1\|2619189_2619924_+\|response-regulator	unknown	unknown	gnl\|CDD\|227095
NZ_CP012475.1\|WP_011248411.1\|2600750_2601539_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_011248409.1\|2602013_2602289_+\|PTS-galactitol-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	1.29288e-38
NZ_CP012475.1\|WP_035203479.1\|2615491_2616391_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.04281e-49
NZ_CP012475.1\|WP_035203494.1\|2603681_2604740_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	2.32129e-165
NZ_CP012475.1\|WP_035203471.1\|2621907_2622792_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.91004e-68
NZ_CP012475.1\|WP_035203481.1\|2611576_2614177_-\|phosphoenolpyruvate-synthase	gnl\|CDD\|235751	PRK06241, PRK06241, phosphoenolpyruvate synthase; Validated.	0
NZ_CP012475.1\|WP_035203482.1\|2609197_2609989_+\|DUF817-domain-containing-protein	gnl\|CDD\|226262	COG3739, COG3739, Uncharacterized integral membrane protein [Function unknown].	1.70048e-129
NZ_CP012475.1\|WP_011248410.1\|2601531_2602011_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	2.57201e-35
NZ_CP012475.1\|WP_035203468.1\|2623701_2626344_+\|alpha-L-rhamnosidase	gnl\|CDD\|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	4.66921e-138
NZ_CP012475.1\|WP_035203492.1\|2604740_2605610_+\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|376459	pfam01116, F_bP_aldolase, Fructose-bisphosphate aldolase class-II.	2.23495e-129
NZ_CP012475.1\|WP_035203489.1\|2606676_2607777_-\|hypothetical-protein	gnl\|CDD\|376220	pfam18801, RapH_N, response regulator aspartate phosphatase H, N terminal. Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.	7.37604e-20
NZ_CP012475.1\|WP_011248408.1\|2602314_2603661_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	4.91628e-164
NZ_CP012475.1\|WP_035203486.1\|2608441_2608918_+\|DUF2975-domain-containing-protein	gnl\|CDD\|378586	pfam11188, DUF2975, Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	8.94473e-34
NZ_CP012475.1\|WP_035203474.1\|2620571_2621852_+\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.40515e-41
NZ_CP012475.1\|WP_051881192.1\|2616533_2617316_+\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.10498e-19
NZ_CP012475.1\|WP_082369160.1\|2622807_2623686_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.05096e-73
NZ_CP012475.1\|WP_035203484.1\|2608928_2609153_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|226181	COG3655, COG3655, Predicted transcriptional regulator [Transcription].	1.58556e-29
NZ_CP012475.1\|WP_051881182.1\|2617498_2619202_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	2.87735e-55
NZ_CP012475.1\|WP_035203478.1\|2619189_2619924_+\|response-regulator	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	3.8685e-51
NZ_CP012475.1\|WP_011248411.1\|2600750_2601539_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	4.3258e-90

>NZ_CP012475.1|WP_035203482.1|2609197_2609989_+|DUF817-domain-containing-protein
MRPLKQLVRFGWEQALSCLFPVVIFASLAITQLVPLPFLPRYDWLLIICLFMQWWMVRSGLETWDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKVFGVPLYSGFMYASVASYLCQAWRRLKIELVKWPSLLLVVPLAAAIYLNFITHHFWIDIRFWLAGLVIIVFWPSWVTYEVNETRYRMPLALSFVLIGFFIWIAENIATFFGAWEYPNQTDAWSLVHLGKVSSWLLLVIVSFLIVATLKQVKGKRRTGVDASQSL
>NZ_CP012475.1|WP_035203484.1|2608928_2609153_+|helix-turn-helix-transcriptional-regulator
MAIIINVDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIRLSTLDAICKALDCQPGDLLEYRSDENLHDE
>NZ_CP012475.1|WP_035203486.1|2608441_2608918_+|DUF2975-domain-containing-protein
MKRGSTLFLKIAVVLMGSPVLALCIFGLAWIPNHPVDPDYGHILYPIFIGVFLTVIPFFVALSQAFKLLSYIDKNQSFSELSTRALKKIKYCAIIISGLYVAIMPFFYLLADRDDAPGLLFMGVVPLFASTVIAVFAAVLQRLFQEAIDIKSENDLTV
>NZ_CP012475.1|WP_035203489.1|2606676_2607777_-|hypothetical-protein
MSAILSPEEVSTIIAEWYSCIIARSVEQANELKEKAENMVKTMEPNDRVIAYYSLVEFRHSIMAKQGGKDEKDDERIQQAGNMIEDSIDHTLKYLYLFVSGQNEFIKERYQSAIRLFRKAERLLEYINDEAEEAEFYYYMGSSLYRINQYPYAASYIEEALLAFNRLGYIERAVYCQVILGGIYSEAGQHEKVRKLLEEALSISNNYPMAQVAVLRIIGLDALRKKAYQKAKEYFEKSLSYPECTETILGVKSEYNLANALFRIGLFNEALPHLTKAYAGAQSYNNHEYQARCIATYGLYVNSNPEEIDQAIKSLSESDMNFEIEEIAEEAATFFKQKGEQELAWKYLNVAYRARQNLSNIGVDQP
>NZ_CP012475.1|WP_035203492.1|2604740_2605610_+|class-II-fructose-bisphosphate-aldolase
MGLQSTTPMLKKAKANKHGIVAFNVHSFDSIFWVLEAAAELKSPVILQTTVGTVKSLGAKNIAEVAKAAAEHYQVPTGLHLDHCTDFEVIKDAIRAGYTSVMMDASMHPFAENVARTKEVVALASSLGVNVEAELGKVGGVEDDIVVDEADAQKAIPEECRQFVEETDVPTLAPAIGTAHGIYKGKPEIDFERIAKIAEMVDVPLVLHGGSAVPEEDVRRCVALGMAKVNVSTELKNAYSEAIRDHFANEPDSLDPRAYLQKAKEAAKEMAKSKIRMVGSENTVVPAFA
>NZ_CP012475.1|WP_035203494.1|2603681_2604740_+|galactitol-1-phosphate-5-dehydrogenase
MKALVLEANQSFTIKDIETPVPKEDEALIKVAYCGICGSDLARYFDGKVHNYPIVLGHEFSGTVEAVGASVDSVTVGDRVVVAPLLPNKDDPFMQKGSPALSSSYSFLGSRENGAMAEYVVVKAENLLVLPETVTLAEAALIEPLTVAIHGIERIVLPAGEHVCVLGAGTIGIMTILALKARGAGKVTAIDINDEKLAFAKKIGADDTINSLKEDPVSYASKHGKPGAVIETAGVPSAQEQAVALVEKKGKIVFVGTASGDVTFPAATFEKILREELEITGSWMSYSGPFPGYEWQAAIDYIASGKIDVKPLIHDVFKLEDGDKPFQAMKDPDNHSIKLLYQIAENEGQVGK
>NZ_CP012475.1|WP_011248408.1|2602314_2603661_+|PTS-galactitol-transporter-subunit-IIC
MNVLQYILDLGPAVMLPAVIFVLGLLLRQGIGKSLRSGITIGVGFVGITLVISLLTDNLGPAAQEMAERFNLGLSIVDVGWPGASPMAWASNIGTVAIPVAILVNVVMLLLKWTRVVNVDIWNIWHMAFAGAIVSTASGSFWLGVLGVVIYAAFAYKLGDWFAPIIHKYNGLEGISIPHGTGAIMAPIAVVTDAIIEKIPGLKNVNINSDKIENRLGPIGEPAIIGAILGTVIGALAGYEVSAILQLGIQMAAVMLLMPTVVKFIMEGLMPIAEAAREMLDKRFSGQDYYIGLDPALLLGNSQVVAASLIFVPLTLVIAILIPGNEVLPFGDLATIGFFISIAVGIHGGNLFRTLISGTLIMTMTIWIANMMVGVHTQLALNTGTISGGQVASLDQGGSPLQFIMTELTTWQNLLPLIVVTAIYGFCVVFTIVQHKRGKLLPAETDKN
>NZ_CP012475.1|WP_011248409.1|2602013_2602289_+|PTS-galactitol-transporter-subunit-IIB
MKKVLVACGGAVATSTVAANKVKAILKENNIQADVSQCRVSELGSKAQGADLIISTAKVDRDYGVPVIHGLPFISGVGLDKTKQEILDILK
>NZ_CP012475.1|WP_011248410.1|2601531_2602011_+|PTS-sugar-transporter-subunit-IIA
MSNALLDRDLILLNQTCQTVEEVLETIAAPMQAKQFAKETYADGLKEREQSFATGIPTEPFGVAIPHTDASYVLESKIGLLTLKEPVSFGVMGSENDQIDVKVVLLLGLADGSAHLKALQTIVERIQDAHFVKKLASVQEKDEALALLDASITKQLEGE
>NZ_CP012475.1|WP_011248411.1|2600750_2601539_+|DeoR/GlpR-transcriptional-regulator
MLPQERQDLIMKELYEYHSVKISELSSKLDVTRETIRKDLYELEEKGLIRKVHGGAVLNKANLETNYSSRKIVNEWEKRAIAKKAVEFVFDNDTIYIDYGTTALYFARELIMKKTGLTIVTNSLSLANELVEHSNFSIIIIGGNVRKNERSLYGPVANQTIANLYVDTGFFGIGALHPEVGYTNIHMGEAEVSRLMVQHSKRRVMMADYSKFGSIHMNKVAPIEEVDTLITDSKADAEMLKAIQAKARNVIVVEAEGGEGDE
>NZ_CP012475.1|WP_035203481.1|2611576_2614177_-|phosphoenolpyruvate-synthase
MSSLVLGFQEMDEKQLLLVGGKGLNLGELSKIQGIQVPEGFCVTTTGFQKAIKQNDTFQALLAQLATLKVEDRDQIGEISRKIRELILEVEIPSDVVKAVAHYLSQFGEKHAYAVRSSATAEDLPHASFAGQQDTFLNIIGKDAILQHISKCWASLFTDRAVIYRMQNGFDHSQVYLSVIVQKMVFPQASGILFTADPMTSNRKVLSIDAGFGLGEALVSGLVSADCYKVREDQIVDKRIATKKLAIYGREEGGTETQQIDPDQQKTQTLTDQQILQLARIGRQIEAHFGQPQDIEWCLANDTFYIVQSRPITTLYPIPETNDQENHVYLSVGHQQMMTDPIKPLGLSFYLLITPAPMRKAGGRLFVDVAPRLTTRAGREALLNTVGSDPLTKSALMTVIEQDYIKLLPTDQSASNPGNSHKGMSEQFETDPTIVSKLIKRSQTSIEQLKQNIQAKSGLDLFDFILEDIEQLKKILFDPQSTAVFMAAINATTWINENMNEWLGEKNAADTLSLSVPHNITSEMGLALMDVADVIRPYPEVIDYLQHAIEDNFLDELVKFDGGQEARNAIDAYLDKYGMRCPGEIDITRTRWSEKPITLVPMILSHINNFEPNEGNRKFEQGRRVALEKEQELINRLKQLPDGEQKAKETKQRIDLIRNFIGYREYPKYGIVSRYFVYKQALLKEAEQLVQAGVIQEKEDIYYLTFEELHEVARTKKTDDQIINKRKDEYKRYEKLTPPRVITSDGEIITGAYKQANLPANAIAGLAVSTGVIEGRASVILNIENADLEDGDILVTSFTDPGWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENATKLIKDGQRIRVNGTDGYVEILNS
>NZ_CP012475.1|WP_035203479.1|2615491_2616391_-|LysR-family-transcriptional-regulator
MNLHALRIFTKVAALKSVTKAADALSISQPAVTIQIRNLEKETGLKLIKTEGRGINLTKEGEFLVKRAESLFNMEQDIENKLIQLKDGELQELHISSTSLPANYLLPTWLAKFKLAYPSVKINLSSGNSYQVVDQLLHYKSDIAFVVKEEWHHPTIQLHHLMDIEFWFIVPTGHKYDGQEVSLHDLMDEPFLVREEGSSTREVLFSLCNLHNVPVPNIGIQFHGLNESIRSVLAGYGAMLAPSLAVKDHIHRNELGKVLVKDIEIKRPVYLCTRKEDAHTIHLSRLIDLINGFTKDDFY
>NZ_CP012475.1|WP_051881192.1|2616533_2617316_+|TSUP-family-transporter
MIISFSFGRSIVDNHLALLVVIGMLSSFIGTLAGGGGLITVPAMMLTGIPIQTSIATNKFSSGIAAMSSVFYLVNRRQLTIQAIVKTVATAFVGGIAGALLTAYISEKTMNVVAFVLLFFALIVTVGSKNWAKGRKGEEVTLSPQSWRPWTPLFIAAYDGGFGPGSSTFGILYYMKKHHTYLKAVQLTRVLILGSCVGGFLVFYQTGFFQWPYAVALAIGSTVGSQVGLLVLPKVPMKLAKGLLLTVTCLLILSIVYKLV
>NZ_CP012475.1|WP_051881182.1|2617498_2619202_+|sensor-histidine-kinase
MFQQLYQLLGLSRFRRKILIIFLLFSIMPILFIGFVSKQLADRSLIETYRERNQAQLVNASKLIDRSLEDIVNIQRLILADRSIRHELVRSNEQVYEGDETIGVDTYRNLQRLLSNYLVDQRYVDSVCLFDAFFRSVCHGGSAEREAQTFQTKKWYLDALNENGGELLFAENVLAEEKDTFSYVKSLRNPEEFKLDRIGLLVVTIDKSLLEDVNTSQESDLIVQSEDYTVLDTRTDGGKSDGVDEASLESENYIFDAYTNSASGWKLYSVISEDKLLGQLNNIGAVTLALGGGMSVLLMIVMIPVSRRLSGPLSQVYESAIQLFGWPPNEQKRGLDELKVIDGTFKRVAFQHKQLNERLMEAKLREKEAELKLLQAQINPHFLYNTLSSIYWLAKMKKQSEIAQMAISLSESFKISLNNGKEHIPLQKELEHIRHYITIQNIRFRGKFQYKEEIDDRLLNVEIIKLLLQPLIENAIIHGLEKKESTGRVLLRAFVEGDTLVFQIKDDGVGMEHTSQAMHGFGLKNVHERIQLYYGGKSGLTIASAVNQGTVVTVRLQLRKGEILCFG
>NZ_CP012475.1|WP_035203478.1|2619189_2619924_+|response-regulator
MLRVIIVDDEPLMVEGMVQMVDWEANGAKVVGTAHSGGEALVLVEKEKPDLIFTDIEMPGMDGLDFLEAIKPISPDSLLFLFSAHTDFHYAKRALKLGVLDYLVKPVTVPMIEDALDRALVQERKLEQKGGGRPEKANHQAIRKALAFIAERYNHDITIEHVAEHIGMNASYFSTLFKKEMGVSYIKYVTKYRMEIAKQLLLMGEKVMDVSEKVGYQSYRHFSETFKKQYQITPSELKTKGRTE
>NZ_CP012475.1|WP_035203477.1|2620139_2620373_-|hypothetical-protein
MKATFIFENGVYVQESPRDGTPVHVLAYLYNLIYQIETNAMVYIGDENDQDTFAEENLHNVKSIVFEFEEQDRFTKE
>NZ_CP012475.1|WP_035203474.1|2620571_2621852_+|extracellular-solute-binding-protein
MKQLTFPLMMLASIVFVGGCSSSSGGEMESSGGEREIHYLSNRTANQGQPRIVMPIMEQFQQNNPDVSLDLETIEQSDLVQRIQLLTASNALPDMFVYESAQLDDLISGDYIVNIEEALGEAGLLDNVRPAALDLMRQLSDTGEMYAVPMELNIEGFWYNKEIFQSLGLEEPQTWDELMAISDVLLENEIQPFALAGQDRWPITRFINAYAVRYYGVDAMQRVADGDLSITDEGFIKAAKTVQEMSERGYFGQGVNAMDYDAATASFLTGQSAMYYMGSWALGEMNDENQNHIGGPENIGFFNVPVVEGGVGTLEDYMMNAGIVTVFSKAGFDEPTREWFTYLYTHYADRAMSEHGMVSGLATSIEPNDDDPLTKLVLDELEQAESSALWFEATFNARKQELAETNAQQLIEGSLTPEQFMSALDE
>NZ_CP012475.1|WP_035203471.1|2621907_2622792_+|sugar-ABC-transporter-permease
MDKVLGNKKTILFFVGPALLLYLLLLIVPTIWSIGYSFFSGSPLRGFDFVGFDNYTVALRDKHFLDSLFASIRYAAFVTTGQVALGLCLALLFVFFLKKHSSLIRTLVFFPVILPAVAVAQLFSKLFEFSPQLGLINDLLAALHLDSYVQAWLAQGDTAFAVLVIMDIWRSIGFYAVILYAGLIDVPDDVIEAARLDGASGLRLVTSIVLPMIRPILLSAVIFSLNGTLKVFESAVALTGGGPGNSTTMLTMYMYNTAFSYGEYGYGSAIAVYLLIICLLVTLLIYRFARKNIA
>NZ_CP012475.1|WP_082369160.1|2622807_2623686_+|carbohydrate-ABC-transporter-permease
MKATLAERAATIGAGKKRGVWLSVLGKGLVGVFLLITVYPVIWLLLSSLKEPSEFMTNSMNALPEGFYLGNYVEAWKTGNMGIYFRNSIFVTFPALIGIVLFGSMAAFAIEKLRWKLKNVVMLLFLAGIMIPVQIVLLPLFQIYFNINLLNSLFGLGLVYLVFGLPLTIFLFASYFKSMPNELMEAAVVDGASIYQIFFTLALPLLKNAIVTVALVQFFFVWNDLIFAMSFIRDSDLRTIQTGLMGFAGEYGQREWGPTFASIALAVVPILLLYTFLNKLVMKGMTSGAVKG
>NZ_CP012475.1|WP_035203468.1|2623701_2626344_+|alpha-L-rhamnosidase
MIAVKEMRCEDRLNPIGLDRQSPQFSWITKSDRPDYEQTRYEIQVSMDAEGKEAIWSKRVFSSQSLAVRYEGPPLESYKRYYWRVRVWAGEEKSDWSGASFFEMGILEATEWKGDWITSAANSDANTFACARQFQAKKPITKAILYATSLGLYELMLNGQRVGHYALTPGWTNYHDRIQYQAYDVSFHLKETNELRALVGEGWYSGYLGWKGQKNTYGNTNALLLQLRLVYEDGSVDWIYTDESWRELATPIQMSDLYNGETYDGRIQFEQIGDMRIFSYPKAHLVAQENEPVAVIEQIRPKRLFRTPKQELVLDMGQNMVGVIEFKVRGKEGQKLQLIHGEVLDHEGNFYRANLRAAEQTVSYICSGEGEAVYRPHFTFQGFQFVKLVGFSEDVSIDDFTGLVMHSDMEQTGDFHTSDSSINQLQHNILWGQKGNFVDVPTDCPQRNERLGWTGDAQIFIRTANFNMGTKRFFQKWLRDLAYNQSGDGSVPFVVPDILNGEFSGNKGRTCAAWGDAAVICPWTLYWSFGDEQVLYEQYESMKAWVDYIRSTSEDGLLWQNEFQLGDWLALDAEENSYYGATDNDLVASAYYAYSTKLLAKTARVIGKVDDYHQYKALFKQIKQAYQKAYMTAPNRLYSDTQTAYVLTLHFGLAEETQRQGLAARLVELIRQNGTHLTTGFVGTPYLCHALSDNGYTDVAYELLFQRTYPSWLYQVDRGATTMWEHWDSIKEDGSFWSTDMNSFNHYAYGSIGDWMYQHIIGLDAVQAGYKTAIIAPKPTEKLTYATGTLKTPYGKLASEWHLQGETLTIKGTVPENTSAYICLPAVANQEEMNALNINPASIASEEAETVFRHMREDSVLIKQGSGPFSYTYQARMAKQ

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Crispr_ID: NZ_CP012475_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_11

2614682-2615179

Orphan

I-C:NA

Consensus_repeat	Method
GTCGCACTCCTTGTGAGTGCGTGGATTGAAAT	CRISPRCasFinder
GTGAGTGCGTGGATTGAAAT	PILER-CR
GTGAGTGCGTGGATTGAAAT	CRT

7 spacers

The CRISPR arrays of NZ_CP012475_11

>merge|NZ_CP012475|11|2614682-2615179|CRISPRCasFinder,PILER-CR,CRT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAATGATGACAGGGTTTAATGATACAAATATCCTCCCTGTCGCACTCTTAGTGAGTGCGTGGATTGAAATACCGAACTCGGTAAAGAATGAAACAATCGCTTTTCGTCGCACTCCTTGTGAGTGCGTGGATTGAAATAACGATTTCCTCTTGATTGATTTTAATAATCATTGTCGCACTCCTTGTGAGTGCGTGGATTGAAATTTCGCTCACGTCAGGCTTCAATGATTTTGACTGGGTCGCACTCCTTGTGAGTGCGTGGATTGAAATATTAAACAATATATCGTCGGAAATAATGCGGGTTGTCGCACTCCTTGTGAGTGCGTGGATTGAAATTCAGCGCAAGTCTTTCCGTAGCCCCTACGCTGGCTAAGTCGCACTCCTTGTGAGTGCGTGGATTGAAATAGGATTACCAGTCTACAAAAGATTGGACGCTTGAGTCGCACTTTTAGTGAGTGCATGGATTGAAAC

>NZ_CP012475|11|11|2614682-2615179|CRISPRCasFinder
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	GATGACAGGGTTTAATGATACAAATATCCTCCCT
GTCGCACTCTTAGTGAGTGCGTGGATTGAAAT	ACCGAACTCGGTAAAGAATGAAACAATCGCTTTTC
GTCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AACGATTTCCTCTTGATTGATTTTAATAATCATT
GTCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TTCGCTCACGTCAGGCTTCAATGATTTTGACTGG
GTCGCACTCCTTGTGAGTGCGTGGATTGAAAT	ATTAAACAATATATCGTCGGAAATAATGCGGGTT
GTCGCACTCCTTGTGAGTGCGTGGATTGAAAT	TCAGCGCAAGTCTTTCCGTAGCCCCTACGCTGGCTAA
GTCGCACTCCTTGTGAGTGCGTGGATTGAAAT	AGGATTACCAGTCTACAAAAGATTGGACGCTTGA
GTCGCACTTTTAGTGAGTGCATGGATTGAAAC

>NZ_CP012475|11|9|2614694-2615113|PILER-CR
GTGAGTGCGTGGATTGAAAT	GATGACAGGGTTTAATGATACAAATATCCTCCCTGTCGCACTCTTA
GTGAGTGCGTGGATTGAAAT	ACCGAACTCGGTAAAGAATGAAACAATCGCTTTTCGTCGCACTCCTT
GTGAGTGCGTGGATTGAAAT	AACGATTTCCTCTTGATTGATTTTAATAATCATTGTCGCACTCCTT
GTGAGTGCGTGGATTGAAAT	TTCGCTCACGTCAGGCTTCAATGATTTTGACTGGGTCGCACTCCTT
GTGAGTGCGTGGATTGAAAT	ATTAAACAATATATCGTCGGAAATAATGCGGGTTGTCGCACTCCTT
GTGAGTGCGTGGATTGAAAT	TCAGCGCAAGTCTTTCCGTAGCCCCTACGCTGGCTAAGTCGCACTCCTT
GTGAGTGCGTGGATTGAAAT

>NZ_CP012475|11|9|2614694-2615179|CRT
GTGAGTGCGTGGATTGAAAT	GATGACAGGGTTTAATGATACAAATATCCTCCCTGTCGCACTCTTA
GTGAGTGCGTGGATTGAAAT	ACCGAACTCGGTAAAGAATGAAACAATCGCTTTTCGTCGCACTCCTT
GTGAGTGCGTGGATTGAAAT	AACGATTTCCTCTTGATTGATTTTAATAATCATTGTCGCACTCCTT
GTGAGTGCGTGGATTGAAAT	TTCGCTCACGTCAGGCTTCAATGATTTTGACTGGGTCGCACTCCTT
GTGAGTGCGTGGATTGAAAT	ATTAAACAATATATCGTCGGAAATAATGCGGGTTGTCGCACTCCTT
GTGAGTGCGTGGATTGAAAT	TCAGCGCAAGTCTTTCCGTAGCCCCTACGCTGGCTAAGTCGCACTCCTT
GTGAGTGCGTGGATTGAAAT	AGGATTACCAGTCTACAAAAGATTGGACGCTTGAGTCGCACTTTTA
GTGAGTGCATGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_011248409.1\|2602013_2602289_+\|PTS-galactitol-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NZ_CP012475.1\|WP_035203479.1\|2615491_2616391_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP012475.1\|WP_035203494.1\|2603681_2604740_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_CP012475.1\|WP_167369565.1\|2626540_2627458_-\|undecaprenyl-diphosphate-synthase-family-protein	unknown	unknown	gnl\|CDD\|259850
NZ_CP012475.1\|WP_035203471.1\|2621907_2622792_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP012475.1\|WP_035203481.1\|2611576_2614177_-\|phosphoenolpyruvate-synthase	unknown	unknown	gnl\|CDD\|235751
NZ_CP012475.1\|WP_035203482.1\|2609197_2609989_+\|DUF817-domain-containing-protein	unknown	unknown	gnl\|CDD\|226262
NZ_CP012475.1\|WP_011248410.1\|2601531_2602011_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NZ_CP012475.1\|WP_035203468.1\|2623701_2626344_+\|alpha-L-rhamnosidase	unknown	unknown	gnl\|CDD\|379971
NZ_CP012475.1\|WP_035203492.1\|2604740_2605610_+\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|376459
NZ_CP012475.1\|WP_035203489.1\|2606676_2607777_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376220
NZ_CP012475.1\|WP_011248408.1\|2602314_2603661_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CP012475.1\|WP_035203486.1\|2608441_2608918_+\|DUF2975-domain-containing-protein	unknown	unknown	gnl\|CDD\|378586
NZ_CP012475.1\|WP_035203474.1\|2620571_2621852_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NZ_CP012475.1\|WP_051881192.1\|2616533_2617316_+\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_CP012475.1\|WP_082369160.1\|2622807_2623686_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP012475.1\|WP_035203484.1\|2608928_2609153_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226181
NZ_CP012475.1\|WP_035203477.1\|2620139_2620373_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_051881182.1\|2617498_2619202_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NZ_CP012475.1\|WP_035203478.1\|2619189_2619924_+\|response-regulator	unknown	unknown	gnl\|CDD\|227095

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_011248409.1\|2602013_2602289_+\|PTS-galactitol-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	1.29288e-38
NZ_CP012475.1\|WP_035203479.1\|2615491_2616391_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.04281e-49
NZ_CP012475.1\|WP_035203494.1\|2603681_2604740_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	2.32129e-165
NZ_CP012475.1\|WP_167369565.1\|2626540_2627458_-\|undecaprenyl-diphosphate-synthase-family-protein	gnl\|CDD\|259850	cd00475, Cis_IPPS, Cis (Z)-Isoprenyl Diphosphate Synthases. Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS) catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl diphosphates. A few can also catalyze the condensation of IPP to trans-geranyl diphosphate to form the short-chain cis,trans- FPP. In prokaryotes, the cis-IPPS, undecaprenyl diphosphate synthase (UPP synthase), catalyzes the formation of the carrier lipid UPP in bacterial cell wall peptidoglycan biosynthesis. Similarly, in eukaryotes, the cis-IPPS, dehydrodolichyl diphosphate (dedol-PP) synthase catalyzes the formation of the polyisoprenoid glycosyl carrier lipid dolichyl monophosphate. cis-IPPS form homodimers and are mechanistically and structurally distinct from trans-IPPS, which lack the DDXXD motifs, yet require Mg2+ for activity.	1.59065e-50
NZ_CP012475.1\|WP_035203471.1\|2621907_2622792_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.91004e-68
NZ_CP012475.1\|WP_035203481.1\|2611576_2614177_-\|phosphoenolpyruvate-synthase	gnl\|CDD\|235751	PRK06241, PRK06241, phosphoenolpyruvate synthase; Validated.	0
NZ_CP012475.1\|WP_035203482.1\|2609197_2609989_+\|DUF817-domain-containing-protein	gnl\|CDD\|226262	COG3739, COG3739, Uncharacterized integral membrane protein [Function unknown].	1.70048e-129
NZ_CP012475.1\|WP_011248410.1\|2601531_2602011_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	2.57201e-35
NZ_CP012475.1\|WP_035203468.1\|2623701_2626344_+\|alpha-L-rhamnosidase	gnl\|CDD\|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	4.66921e-138
NZ_CP012475.1\|WP_035203492.1\|2604740_2605610_+\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|376459	pfam01116, F_bP_aldolase, Fructose-bisphosphate aldolase class-II.	2.23495e-129
NZ_CP012475.1\|WP_035203489.1\|2606676_2607777_-\|hypothetical-protein	gnl\|CDD\|376220	pfam18801, RapH_N, response regulator aspartate phosphatase H, N terminal. Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.	7.37604e-20
NZ_CP012475.1\|WP_011248408.1\|2602314_2603661_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	4.91628e-164
NZ_CP012475.1\|WP_035203486.1\|2608441_2608918_+\|DUF2975-domain-containing-protein	gnl\|CDD\|378586	pfam11188, DUF2975, Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	8.94473e-34
NZ_CP012475.1\|WP_035203474.1\|2620571_2621852_+\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.40515e-41
NZ_CP012475.1\|WP_051881192.1\|2616533_2617316_+\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.10498e-19
NZ_CP012475.1\|WP_082369160.1\|2622807_2623686_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.05096e-73
NZ_CP012475.1\|WP_035203484.1\|2608928_2609153_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|226181	COG3655, COG3655, Predicted transcriptional regulator [Transcription].	1.58556e-29
NZ_CP012475.1\|WP_051881182.1\|2617498_2619202_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	2.87735e-55
NZ_CP012475.1\|WP_035203478.1\|2619189_2619924_+\|response-regulator	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	3.8685e-51

>NZ_CP012475.1|WP_035203481.1|2611576_2614177_-|phosphoenolpyruvate-synthase
MSSLVLGFQEMDEKQLLLVGGKGLNLGELSKIQGIQVPEGFCVTTTGFQKAIKQNDTFQALLAQLATLKVEDRDQIGEISRKIRELILEVEIPSDVVKAVAHYLSQFGEKHAYAVRSSATAEDLPHASFAGQQDTFLNIIGKDAILQHISKCWASLFTDRAVIYRMQNGFDHSQVYLSVIVQKMVFPQASGILFTADPMTSNRKVLSIDAGFGLGEALVSGLVSADCYKVREDQIVDKRIATKKLAIYGREEGGTETQQIDPDQQKTQTLTDQQILQLARIGRQIEAHFGQPQDIEWCLANDTFYIVQSRPITTLYPIPETNDQENHVYLSVGHQQMMTDPIKPLGLSFYLLITPAPMRKAGGRLFVDVAPRLTTRAGREALLNTVGSDPLTKSALMTVIEQDYIKLLPTDQSASNPGNSHKGMSEQFETDPTIVSKLIKRSQTSIEQLKQNIQAKSGLDLFDFILEDIEQLKKILFDPQSTAVFMAAINATTWINENMNEWLGEKNAADTLSLSVPHNITSEMGLALMDVADVIRPYPEVIDYLQHAIEDNFLDELVKFDGGQEARNAIDAYLDKYGMRCPGEIDITRTRWSEKPITLVPMILSHINNFEPNEGNRKFEQGRRVALEKEQELINRLKQLPDGEQKAKETKQRIDLIRNFIGYREYPKYGIVSRYFVYKQALLKEAEQLVQAGVIQEKEDIYYLTFEELHEVARTKKTDDQIINKRKDEYKRYEKLTPPRVITSDGEIITGAYKQANLPANAIAGLAVSTGVIEGRASVILNIENADLEDGDILVTSFTDPGWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENATKLIKDGQRIRVNGTDGYVEILNS
>NZ_CP012475.1|WP_035203482.1|2609197_2609989_+|DUF817-domain-containing-protein
MRPLKQLVRFGWEQALSCLFPVVIFASLAITQLVPLPFLPRYDWLLIICLFMQWWMVRSGLETWDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKVFGVPLYSGFMYASVASYLCQAWRRLKIELVKWPSLLLVVPLAAAIYLNFITHHFWIDIRFWLAGLVIIVFWPSWVTYEVNETRYRMPLALSFVLIGFFIWIAENIATFFGAWEYPNQTDAWSLVHLGKVSSWLLLVIVSFLIVATLKQVKGKRRTGVDASQSL
>NZ_CP012475.1|WP_035203484.1|2608928_2609153_+|helix-turn-helix-transcriptional-regulator
MAIIINVDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIRLSTLDAICKALDCQPGDLLEYRSDENLHDE
>NZ_CP012475.1|WP_035203486.1|2608441_2608918_+|DUF2975-domain-containing-protein
MKRGSTLFLKIAVVLMGSPVLALCIFGLAWIPNHPVDPDYGHILYPIFIGVFLTVIPFFVALSQAFKLLSYIDKNQSFSELSTRALKKIKYCAIIISGLYVAIMPFFYLLADRDDAPGLLFMGVVPLFASTVIAVFAAVLQRLFQEAIDIKSENDLTV
>NZ_CP012475.1|WP_035203489.1|2606676_2607777_-|hypothetical-protein
MSAILSPEEVSTIIAEWYSCIIARSVEQANELKEKAENMVKTMEPNDRVIAYYSLVEFRHSIMAKQGGKDEKDDERIQQAGNMIEDSIDHTLKYLYLFVSGQNEFIKERYQSAIRLFRKAERLLEYINDEAEEAEFYYYMGSSLYRINQYPYAASYIEEALLAFNRLGYIERAVYCQVILGGIYSEAGQHEKVRKLLEEALSISNNYPMAQVAVLRIIGLDALRKKAYQKAKEYFEKSLSYPECTETILGVKSEYNLANALFRIGLFNEALPHLTKAYAGAQSYNNHEYQARCIATYGLYVNSNPEEIDQAIKSLSESDMNFEIEEIAEEAATFFKQKGEQELAWKYLNVAYRARQNLSNIGVDQP
>NZ_CP012475.1|WP_035203492.1|2604740_2605610_+|class-II-fructose-bisphosphate-aldolase
MGLQSTTPMLKKAKANKHGIVAFNVHSFDSIFWVLEAAAELKSPVILQTTVGTVKSLGAKNIAEVAKAAAEHYQVPTGLHLDHCTDFEVIKDAIRAGYTSVMMDASMHPFAENVARTKEVVALASSLGVNVEAELGKVGGVEDDIVVDEADAQKAIPEECRQFVEETDVPTLAPAIGTAHGIYKGKPEIDFERIAKIAEMVDVPLVLHGGSAVPEEDVRRCVALGMAKVNVSTELKNAYSEAIRDHFANEPDSLDPRAYLQKAKEAAKEMAKSKIRMVGSENTVVPAFA
>NZ_CP012475.1|WP_035203494.1|2603681_2604740_+|galactitol-1-phosphate-5-dehydrogenase
MKALVLEANQSFTIKDIETPVPKEDEALIKVAYCGICGSDLARYFDGKVHNYPIVLGHEFSGTVEAVGASVDSVTVGDRVVVAPLLPNKDDPFMQKGSPALSSSYSFLGSRENGAMAEYVVVKAENLLVLPETVTLAEAALIEPLTVAIHGIERIVLPAGEHVCVLGAGTIGIMTILALKARGAGKVTAIDINDEKLAFAKKIGADDTINSLKEDPVSYASKHGKPGAVIETAGVPSAQEQAVALVEKKGKIVFVGTASGDVTFPAATFEKILREELEITGSWMSYSGPFPGYEWQAAIDYIASGKIDVKPLIHDVFKLEDGDKPFQAMKDPDNHSIKLLYQIAENEGQVGK
>NZ_CP012475.1|WP_011248408.1|2602314_2603661_+|PTS-galactitol-transporter-subunit-IIC
MNVLQYILDLGPAVMLPAVIFVLGLLLRQGIGKSLRSGITIGVGFVGITLVISLLTDNLGPAAQEMAERFNLGLSIVDVGWPGASPMAWASNIGTVAIPVAILVNVVMLLLKWTRVVNVDIWNIWHMAFAGAIVSTASGSFWLGVLGVVIYAAFAYKLGDWFAPIIHKYNGLEGISIPHGTGAIMAPIAVVTDAIIEKIPGLKNVNINSDKIENRLGPIGEPAIIGAILGTVIGALAGYEVSAILQLGIQMAAVMLLMPTVVKFIMEGLMPIAEAAREMLDKRFSGQDYYIGLDPALLLGNSQVVAASLIFVPLTLVIAILIPGNEVLPFGDLATIGFFISIAVGIHGGNLFRTLISGTLIMTMTIWIANMMVGVHTQLALNTGTISGGQVASLDQGGSPLQFIMTELTTWQNLLPLIVVTAIYGFCVVFTIVQHKRGKLLPAETDKN
>NZ_CP012475.1|WP_011248409.1|2602013_2602289_+|PTS-galactitol-transporter-subunit-IIB
MKKVLVACGGAVATSTVAANKVKAILKENNIQADVSQCRVSELGSKAQGADLIISTAKVDRDYGVPVIHGLPFISGVGLDKTKQEILDILK
>NZ_CP012475.1|WP_011248410.1|2601531_2602011_+|PTS-sugar-transporter-subunit-IIA
MSNALLDRDLILLNQTCQTVEEVLETIAAPMQAKQFAKETYADGLKEREQSFATGIPTEPFGVAIPHTDASYVLESKIGLLTLKEPVSFGVMGSENDQIDVKVVLLLGLADGSAHLKALQTIVERIQDAHFVKKLASVQEKDEALALLDASITKQLEGE
>NZ_CP012475.1|WP_035203479.1|2615491_2616391_-|LysR-family-transcriptional-regulator
MNLHALRIFTKVAALKSVTKAADALSISQPAVTIQIRNLEKETGLKLIKTEGRGINLTKEGEFLVKRAESLFNMEQDIENKLIQLKDGELQELHISSTSLPANYLLPTWLAKFKLAYPSVKINLSSGNSYQVVDQLLHYKSDIAFVVKEEWHHPTIQLHHLMDIEFWFIVPTGHKYDGQEVSLHDLMDEPFLVREEGSSTREVLFSLCNLHNVPVPNIGIQFHGLNESIRSVLAGYGAMLAPSLAVKDHIHRNELGKVLVKDIEIKRPVYLCTRKEDAHTIHLSRLIDLINGFTKDDFY
>NZ_CP012475.1|WP_051881192.1|2616533_2617316_+|TSUP-family-transporter
MIISFSFGRSIVDNHLALLVVIGMLSSFIGTLAGGGGLITVPAMMLTGIPIQTSIATNKFSSGIAAMSSVFYLVNRRQLTIQAIVKTVATAFVGGIAGALLTAYISEKTMNVVAFVLLFFALIVTVGSKNWAKGRKGEEVTLSPQSWRPWTPLFIAAYDGGFGPGSSTFGILYYMKKHHTYLKAVQLTRVLILGSCVGGFLVFYQTGFFQWPYAVALAIGSTVGSQVGLLVLPKVPMKLAKGLLLTVTCLLILSIVYKLV
>NZ_CP012475.1|WP_051881182.1|2617498_2619202_+|sensor-histidine-kinase
MFQQLYQLLGLSRFRRKILIIFLLFSIMPILFIGFVSKQLADRSLIETYRERNQAQLVNASKLIDRSLEDIVNIQRLILADRSIRHELVRSNEQVYEGDETIGVDTYRNLQRLLSNYLVDQRYVDSVCLFDAFFRSVCHGGSAEREAQTFQTKKWYLDALNENGGELLFAENVLAEEKDTFSYVKSLRNPEEFKLDRIGLLVVTIDKSLLEDVNTSQESDLIVQSEDYTVLDTRTDGGKSDGVDEASLESENYIFDAYTNSASGWKLYSVISEDKLLGQLNNIGAVTLALGGGMSVLLMIVMIPVSRRLSGPLSQVYESAIQLFGWPPNEQKRGLDELKVIDGTFKRVAFQHKQLNERLMEAKLREKEAELKLLQAQINPHFLYNTLSSIYWLAKMKKQSEIAQMAISLSESFKISLNNGKEHIPLQKELEHIRHYITIQNIRFRGKFQYKEEIDDRLLNVEIIKLLLQPLIENAIIHGLEKKESTGRVLLRAFVEGDTLVFQIKDDGVGMEHTSQAMHGFGLKNVHERIQLYYGGKSGLTIASAVNQGTVVTVRLQLRKGEILCFG
>NZ_CP012475.1|WP_035203478.1|2619189_2619924_+|response-regulator
MLRVIIVDDEPLMVEGMVQMVDWEANGAKVVGTAHSGGEALVLVEKEKPDLIFTDIEMPGMDGLDFLEAIKPISPDSLLFLFSAHTDFHYAKRALKLGVLDYLVKPVTVPMIEDALDRALVQERKLEQKGGGRPEKANHQAIRKALAFIAERYNHDITIEHVAEHIGMNASYFSTLFKKEMGVSYIKYVTKYRMEIAKQLLLMGEKVMDVSEKVGYQSYRHFSETFKKQYQITPSELKTKGRTE
>NZ_CP012475.1|WP_035203477.1|2620139_2620373_-|hypothetical-protein
MKATFIFENGVYVQESPRDGTPVHVLAYLYNLIYQIETNAMVYIGDENDQDTFAEENLHNVKSIVFEFEEQDRFTKE
>NZ_CP012475.1|WP_035203474.1|2620571_2621852_+|extracellular-solute-binding-protein
MKQLTFPLMMLASIVFVGGCSSSSGGEMESSGGEREIHYLSNRTANQGQPRIVMPIMEQFQQNNPDVSLDLETIEQSDLVQRIQLLTASNALPDMFVYESAQLDDLISGDYIVNIEEALGEAGLLDNVRPAALDLMRQLSDTGEMYAVPMELNIEGFWYNKEIFQSLGLEEPQTWDELMAISDVLLENEIQPFALAGQDRWPITRFINAYAVRYYGVDAMQRVADGDLSITDEGFIKAAKTVQEMSERGYFGQGVNAMDYDAATASFLTGQSAMYYMGSWALGEMNDENQNHIGGPENIGFFNVPVVEGGVGTLEDYMMNAGIVTVFSKAGFDEPTREWFTYLYTHYADRAMSEHGMVSGLATSIEPNDDDPLTKLVLDELEQAESSALWFEATFNARKQELAETNAQQLIEGSLTPEQFMSALDE
>NZ_CP012475.1|WP_035203471.1|2621907_2622792_+|sugar-ABC-transporter-permease
MDKVLGNKKTILFFVGPALLLYLLLLIVPTIWSIGYSFFSGSPLRGFDFVGFDNYTVALRDKHFLDSLFASIRYAAFVTTGQVALGLCLALLFVFFLKKHSSLIRTLVFFPVILPAVAVAQLFSKLFEFSPQLGLINDLLAALHLDSYVQAWLAQGDTAFAVLVIMDIWRSIGFYAVILYAGLIDVPDDVIEAARLDGASGLRLVTSIVLPMIRPILLSAVIFSLNGTLKVFESAVALTGGGPGNSTTMLTMYMYNTAFSYGEYGYGSAIAVYLLIICLLVTLLIYRFARKNIA
>NZ_CP012475.1|WP_082369160.1|2622807_2623686_+|carbohydrate-ABC-transporter-permease
MKATLAERAATIGAGKKRGVWLSVLGKGLVGVFLLITVYPVIWLLLSSLKEPSEFMTNSMNALPEGFYLGNYVEAWKTGNMGIYFRNSIFVTFPALIGIVLFGSMAAFAIEKLRWKLKNVVMLLFLAGIMIPVQIVLLPLFQIYFNINLLNSLFGLGLVYLVFGLPLTIFLFASYFKSMPNELMEAAVVDGASIYQIFFTLALPLLKNAIVTVALVQFFFVWNDLIFAMSFIRDSDLRTIQTGLMGFAGEYGQREWGPTFASIALAVVPILLLYTFLNKLVMKGMTSGAVKG
>NZ_CP012475.1|WP_035203468.1|2623701_2626344_+|alpha-L-rhamnosidase
MIAVKEMRCEDRLNPIGLDRQSPQFSWITKSDRPDYEQTRYEIQVSMDAEGKEAIWSKRVFSSQSLAVRYEGPPLESYKRYYWRVRVWAGEEKSDWSGASFFEMGILEATEWKGDWITSAANSDANTFACARQFQAKKPITKAILYATSLGLYELMLNGQRVGHYALTPGWTNYHDRIQYQAYDVSFHLKETNELRALVGEGWYSGYLGWKGQKNTYGNTNALLLQLRLVYEDGSVDWIYTDESWRELATPIQMSDLYNGETYDGRIQFEQIGDMRIFSYPKAHLVAQENEPVAVIEQIRPKRLFRTPKQELVLDMGQNMVGVIEFKVRGKEGQKLQLIHGEVLDHEGNFYRANLRAAEQTVSYICSGEGEAVYRPHFTFQGFQFVKLVGFSEDVSIDDFTGLVMHSDMEQTGDFHTSDSSINQLQHNILWGQKGNFVDVPTDCPQRNERLGWTGDAQIFIRTANFNMGTKRFFQKWLRDLAYNQSGDGSVPFVVPDILNGEFSGNKGRTCAAWGDAAVICPWTLYWSFGDEQVLYEQYESMKAWVDYIRSTSEDGLLWQNEFQLGDWLALDAEENSYYGATDNDLVASAYYAYSTKLLAKTARVIGKVDDYHQYKALFKQIKQAYQKAYMTAPNRLYSDTQTAYVLTLHFGLAEETQRQGLAARLVELIRQNGTHLTTGFVGTPYLCHALSDNGYTDVAYELLFQRTYPSWLYQVDRGATTMWEHWDSIKEDGSFWSTDMNSFNHYAYGSIGDWMYQHIIGLDAVQAGYKTAIIAPKPTEKLTYATGTLKTPYGKLASEWHLQGETLTIKGTVPENTSAYICLPAVANQEEMNALNINPASIASEEAETVFRHMREDSVLIKQGSGPFSYTYQARMAKQ
>NZ_CP012475.1|WP_167369565.1|2626540_2627458_-|undecaprenyl-diphosphate-synthase-family-protein
MPENRFRFFRCHSCRAYVKRFSIFLVATIAKQIGFLNDSVYRLTSGKIKLYDERIVNVPRERIIINFINHIAIIPDGNRRWAKKKGLLSEGSLYDKGAANFQYITEALFSKGVNYVTFWVSSVDNLKNREKSLVKAMHKLYAKKFTELLNDPKIMENKIKVQVCGSWRTFLEKDTIDIIEKLLVKTANNDKGILTLLVAYDGKIERGQAVISLLDDHVLEKNINKDPLTFNSLLKKHSWTGYLPSVDFIIRTGSWNDPHNSADFLSFLTGDSQLYFPEVYWPDFDSNWLEKSLQEYVSRERRKGS

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Crispr_ID: NZ_CP012475_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_12

2627814-2628047

Orphan

I-C

Consensus_repeat	Method
TGTCGCACTCTTTGTGAGTGCGTGGATTGAAATA	PILER-CR
TGTCGCACTCTTTGTGAGTGCGTGGATTGAAATA	CRT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP012475_12

>merge|NZ_CP012475|12|2627814-2628047|PILER-CR,CRT,CRISPRCasFinder
TGTCGCACTCTTTGTGAGTGCGTGGATTGAAATAGCAGGGAGAACCTTTTCAATCGATATTCCCATAGTCGCACTCTTTGTGAGTGCGTGGATTGAAATATAATATATTCCCACCAATCTGTATCATTGACTATGTCGCACTCTTTGTGAGTGCGTGGATTGAAATCAACAACAGGTCAAGTTGGGCATGGTACTGTCTTTGTCGCACTCTTCGTAAGTGCGTGCTCGTTCGTA

>NZ_CP012475|12|10|2627814-2627980|PILER-CR
TGTCGCACTCTTTGTGAGTGCGTGGATTGAAATA	GCAGGGAGAACCTTTTCAATCGATATTCCCAT
AGTCGCACTCTTTGTGAGTGCGTGGATTGAAATA	TAATATATTCCCACCAATCTGTATCATTGACTA
TGTCGCACTCTTTGTGAGTGCGTGGATTGAAATC

>NZ_CP012475|12|10|2627814-2628047|CRT
TGTCGCACTCTTTGTGAGTGCGTGGATTGAAATA	GCAGGGAGAACCTTTTCAATCGATATTCCCAT
AGTCGCACTCTTTGTGAGTGCGTGGATTGAAATA	TAATATATTCCCACCAATCTGTATCATTGACTA
TGTCGCACTCTTTGTGAGTGCGTGGATTGAAATC	AACAACAGGTCAAGTTGGGCATGGTACTGTCTT
TGTCGCACTCTTCGTAAGTGCGTGCTCGTTCGTA

>NZ_CP012475|12|12|2627815-2628046|CRISPRCasFinder
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	AGCAGGGAGAACCTTTTCAATCGATATTCCCATA
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	ATAATATATTCCCACCAATCTGTATCATTGACTAT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CAACAACAGGTCAAGTTGGGCATGGTACTGTCTTT
GTCGCACTCTTCGTAAGTGCGTGCTCGTTCGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_167369565.1\|2626540_2627458_-\|undecaprenyl-diphosphate-synthase-family-protein	unknown	unknown	gnl\|CDD\|259850
NZ_CP012475.1\|WP_035203468.1\|2623701_2626344_+\|alpha-L-rhamnosidase	unknown	unknown	gnl\|CDD\|379971
NZ_CP012475.1\|WP_035203455.1\|2632465_2632963_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_051881180.1\|2637489_2644791_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|227268
NZ_CP012475.1\|WP_035203710.1\|2630642_2631998_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273919
NZ_CP012475.1\|WP_011248403.1\|2644807_2645398_+\|class-D-sortase	unknown	unknown	gnl\|CDD\|320681
NZ_CP012475.1\|WP_035203471.1\|2621907_2622792_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP012475.1\|WP_035203478.1\|2619189_2619924_+\|response-regulator	unknown	unknown	gnl\|CDD\|227095
NZ_CP012475.1\|WP_035203479.1\|2615491_2616391_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP012475.1\|WP_051881182.1\|2617498_2619202_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NZ_CP012475.1\|WP_051881181.1\|2636167_2637286_-\|response-regulator	unknown	unknown	gnl\|CDD\|226456
NZ_CP012475.1\|WP_035203463.1\|2628358_2629066_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP012475.1\|WP_011248401.1\|2645705_2646044_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP012475.1\|WP_035203474.1\|2620571_2621852_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NZ_CP012475.1\|WP_051881192.1\|2616533_2617316_+\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_CP012475.1\|WP_082369160.1\|2622807_2623686_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP012475.1\|WP_035203460.1\|2629146_2630346_-\|2-dehydro-3-deoxy-6-phosphogalactonate-aldolase	unknown	unknown	gnl\|CDD\|239438
NZ_CP012475.1\|WP_035203452.1\|2633130_2636094_-\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NZ_CP012475.1\|WP_035203477.1\|2620139_2620373_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035203450.1\|2646321_2646576_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_167369565.1\|2626540_2627458_-\|undecaprenyl-diphosphate-synthase-family-protein	gnl\|CDD\|259850	cd00475, Cis_IPPS, Cis (Z)-Isoprenyl Diphosphate Synthases. Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS) catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl diphosphates. A few can also catalyze the condensation of IPP to trans-geranyl diphosphate to form the short-chain cis,trans- FPP. In prokaryotes, the cis-IPPS, undecaprenyl diphosphate synthase (UPP synthase), catalyzes the formation of the carrier lipid UPP in bacterial cell wall peptidoglycan biosynthesis. Similarly, in eukaryotes, the cis-IPPS, dehydrodolichyl diphosphate (dedol-PP) synthase catalyzes the formation of the polyisoprenoid glycosyl carrier lipid dolichyl monophosphate. cis-IPPS form homodimers and are mechanistically and structurally distinct from trans-IPPS, which lack the DDXXD motifs, yet require Mg2+ for activity.	1.59065e-50
NZ_CP012475.1\|WP_035203468.1\|2623701_2626344_+\|alpha-L-rhamnosidase	gnl\|CDD\|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	4.66921e-138
NZ_CP012475.1\|WP_051881180.1\|2637489_2644791_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|227268	COG4932, COG4932, Predicted outer membrane protein [Cell envelope biogenesis, outer membrane].	0
NZ_CP012475.1\|WP_035203710.1\|2630642_2631998_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273919	TIGR01995, beta-glucosides_PTS_EIIBCA, PTS system, beta-glucoside-specific IIABC component. This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.	1.38885e-136
NZ_CP012475.1\|WP_011248403.1\|2644807_2645398_+\|class-D-sortase	gnl\|CDD\|320681	cd06166, Sortase_D_2, Sortase domain found in subfamily 2 of the class D family of sortases. Class D sortases are cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They anchor surface proteins bearing a cell wall sorting signal to peptidoglycans of the bacterial cell wall envelope, which is responsible for spore formation under anaerobic conditions. This involves a transpeptidation reaction in which the surface protein substrate is cleaved at the cell wall sorting signal and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical subfamily 2 of class D sortase from Clostridium perfringens (named Cp-SrtD) recognizes the LPQTGS signal motif for transpeptidation. Its catalytic activity is in a metal cation- and temperature- dependent manner. The presence of magnesium appears to enhance Cp-SrtD catalysis towards the LPQTGS signal motif.	2.16901e-46
NZ_CP012475.1\|WP_035203460.1\|2629146_2630346_-\|2-dehydro-3-deoxy-6-phosphogalactonate-aldolase	gnl\|CDD\|239438	cd03322, RspA, The starvation sensing protein RspA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subfamily share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and catalytic residues, a partially conserved Lys-X-Lys motif and a conserved histidine-aspartate dyad.	0
NZ_CP012475.1\|WP_035203478.1\|2619189_2619924_+\|response-regulator	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	3.8685e-51
NZ_CP012475.1\|WP_035203471.1\|2621907_2622792_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.91004e-68
NZ_CP012475.1\|WP_051881182.1\|2617498_2619202_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	2.87735e-55
NZ_CP012475.1\|WP_051881181.1\|2636167_2637286_-\|response-regulator	gnl\|CDD\|226456	COG3947, COG3947, Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms].	1.49673e-83
NZ_CP012475.1\|WP_035203479.1\|2615491_2616391_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.04281e-49
NZ_CP012475.1\|WP_035203463.1\|2628358_2629066_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.47938e-49
NZ_CP012475.1\|WP_011248401.1\|2645705_2646044_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.27383e-14
NZ_CP012475.1\|WP_035203474.1\|2620571_2621852_+\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.40515e-41
NZ_CP012475.1\|WP_051881192.1\|2616533_2617316_+\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.10498e-19
NZ_CP012475.1\|WP_082369160.1\|2622807_2623686_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.05096e-73
NZ_CP012475.1\|WP_035203452.1\|2633130_2636094_-\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	7.4718e-49

>NZ_CP012475.1|WP_167369565.1|2626540_2627458_-|undecaprenyl-diphosphate-synthase-family-protein
MPENRFRFFRCHSCRAYVKRFSIFLVATIAKQIGFLNDSVYRLTSGKIKLYDERIVNVPRERIIINFINHIAIIPDGNRRWAKKKGLLSEGSLYDKGAANFQYITEALFSKGVNYVTFWVSSVDNLKNREKSLVKAMHKLYAKKFTELLNDPKIMENKIKVQVCGSWRTFLEKDTIDIIEKLLVKTANNDKGILTLLVAYDGKIERGQAVISLLDDHVLEKNINKDPLTFNSLLKKHSWTGYLPSVDFIIRTGSWNDPHNSADFLSFLTGDSQLYFPEVYWPDFDSNWLEKSLQEYVSRERRKGS
>NZ_CP012475.1|WP_035203468.1|2623701_2626344_+|alpha-L-rhamnosidase
MIAVKEMRCEDRLNPIGLDRQSPQFSWITKSDRPDYEQTRYEIQVSMDAEGKEAIWSKRVFSSQSLAVRYEGPPLESYKRYYWRVRVWAGEEKSDWSGASFFEMGILEATEWKGDWITSAANSDANTFACARQFQAKKPITKAILYATSLGLYELMLNGQRVGHYALTPGWTNYHDRIQYQAYDVSFHLKETNELRALVGEGWYSGYLGWKGQKNTYGNTNALLLQLRLVYEDGSVDWIYTDESWRELATPIQMSDLYNGETYDGRIQFEQIGDMRIFSYPKAHLVAQENEPVAVIEQIRPKRLFRTPKQELVLDMGQNMVGVIEFKVRGKEGQKLQLIHGEVLDHEGNFYRANLRAAEQTVSYICSGEGEAVYRPHFTFQGFQFVKLVGFSEDVSIDDFTGLVMHSDMEQTGDFHTSDSSINQLQHNILWGQKGNFVDVPTDCPQRNERLGWTGDAQIFIRTANFNMGTKRFFQKWLRDLAYNQSGDGSVPFVVPDILNGEFSGNKGRTCAAWGDAAVICPWTLYWSFGDEQVLYEQYESMKAWVDYIRSTSEDGLLWQNEFQLGDWLALDAEENSYYGATDNDLVASAYYAYSTKLLAKTARVIGKVDDYHQYKALFKQIKQAYQKAYMTAPNRLYSDTQTAYVLTLHFGLAEETQRQGLAARLVELIRQNGTHLTTGFVGTPYLCHALSDNGYTDVAYELLFQRTYPSWLYQVDRGATTMWEHWDSIKEDGSFWSTDMNSFNHYAYGSIGDWMYQHIIGLDAVQAGYKTAIIAPKPTEKLTYATGTLKTPYGKLASEWHLQGETLTIKGTVPENTSAYICLPAVANQEEMNALNINPASIASEEAETVFRHMREDSVLIKQGSGPFSYTYQARMAKQ
>NZ_CP012475.1|WP_082369160.1|2622807_2623686_+|carbohydrate-ABC-transporter-permease
MKATLAERAATIGAGKKRGVWLSVLGKGLVGVFLLITVYPVIWLLLSSLKEPSEFMTNSMNALPEGFYLGNYVEAWKTGNMGIYFRNSIFVTFPALIGIVLFGSMAAFAIEKLRWKLKNVVMLLFLAGIMIPVQIVLLPLFQIYFNINLLNSLFGLGLVYLVFGLPLTIFLFASYFKSMPNELMEAAVVDGASIYQIFFTLALPLLKNAIVTVALVQFFFVWNDLIFAMSFIRDSDLRTIQTGLMGFAGEYGQREWGPTFASIALAVVPILLLYTFLNKLVMKGMTSGAVKG
>NZ_CP012475.1|WP_035203471.1|2621907_2622792_+|sugar-ABC-transporter-permease
MDKVLGNKKTILFFVGPALLLYLLLLIVPTIWSIGYSFFSGSPLRGFDFVGFDNYTVALRDKHFLDSLFASIRYAAFVTTGQVALGLCLALLFVFFLKKHSSLIRTLVFFPVILPAVAVAQLFSKLFEFSPQLGLINDLLAALHLDSYVQAWLAQGDTAFAVLVIMDIWRSIGFYAVILYAGLIDVPDDVIEAARLDGASGLRLVTSIVLPMIRPILLSAVIFSLNGTLKVFESAVALTGGGPGNSTTMLTMYMYNTAFSYGEYGYGSAIAVYLLIICLLVTLLIYRFARKNIA
>NZ_CP012475.1|WP_035203474.1|2620571_2621852_+|extracellular-solute-binding-protein
MKQLTFPLMMLASIVFVGGCSSSSGGEMESSGGEREIHYLSNRTANQGQPRIVMPIMEQFQQNNPDVSLDLETIEQSDLVQRIQLLTASNALPDMFVYESAQLDDLISGDYIVNIEEALGEAGLLDNVRPAALDLMRQLSDTGEMYAVPMELNIEGFWYNKEIFQSLGLEEPQTWDELMAISDVLLENEIQPFALAGQDRWPITRFINAYAVRYYGVDAMQRVADGDLSITDEGFIKAAKTVQEMSERGYFGQGVNAMDYDAATASFLTGQSAMYYMGSWALGEMNDENQNHIGGPENIGFFNVPVVEGGVGTLEDYMMNAGIVTVFSKAGFDEPTREWFTYLYTHYADRAMSEHGMVSGLATSIEPNDDDPLTKLVLDELEQAESSALWFEATFNARKQELAETNAQQLIEGSLTPEQFMSALDE
>NZ_CP012475.1|WP_035203477.1|2620139_2620373_-|hypothetical-protein
MKATFIFENGVYVQESPRDGTPVHVLAYLYNLIYQIETNAMVYIGDENDQDTFAEENLHNVKSIVFEFEEQDRFTKE
>NZ_CP012475.1|WP_035203478.1|2619189_2619924_+|response-regulator
MLRVIIVDDEPLMVEGMVQMVDWEANGAKVVGTAHSGGEALVLVEKEKPDLIFTDIEMPGMDGLDFLEAIKPISPDSLLFLFSAHTDFHYAKRALKLGVLDYLVKPVTVPMIEDALDRALVQERKLEQKGGGRPEKANHQAIRKALAFIAERYNHDITIEHVAEHIGMNASYFSTLFKKEMGVSYIKYVTKYRMEIAKQLLLMGEKVMDVSEKVGYQSYRHFSETFKKQYQITPSELKTKGRTE
>NZ_CP012475.1|WP_051881182.1|2617498_2619202_+|sensor-histidine-kinase
MFQQLYQLLGLSRFRRKILIIFLLFSIMPILFIGFVSKQLADRSLIETYRERNQAQLVNASKLIDRSLEDIVNIQRLILADRSIRHELVRSNEQVYEGDETIGVDTYRNLQRLLSNYLVDQRYVDSVCLFDAFFRSVCHGGSAEREAQTFQTKKWYLDALNENGGELLFAENVLAEEKDTFSYVKSLRNPEEFKLDRIGLLVVTIDKSLLEDVNTSQESDLIVQSEDYTVLDTRTDGGKSDGVDEASLESENYIFDAYTNSASGWKLYSVISEDKLLGQLNNIGAVTLALGGGMSVLLMIVMIPVSRRLSGPLSQVYESAIQLFGWPPNEQKRGLDELKVIDGTFKRVAFQHKQLNERLMEAKLREKEAELKLLQAQINPHFLYNTLSSIYWLAKMKKQSEIAQMAISLSESFKISLNNGKEHIPLQKELEHIRHYITIQNIRFRGKFQYKEEIDDRLLNVEIIKLLLQPLIENAIIHGLEKKESTGRVLLRAFVEGDTLVFQIKDDGVGMEHTSQAMHGFGLKNVHERIQLYYGGKSGLTIASAVNQGTVVTVRLQLRKGEILCFG
>NZ_CP012475.1|WP_051881192.1|2616533_2617316_+|TSUP-family-transporter
MIISFSFGRSIVDNHLALLVVIGMLSSFIGTLAGGGGLITVPAMMLTGIPIQTSIATNKFSSGIAAMSSVFYLVNRRQLTIQAIVKTVATAFVGGIAGALLTAYISEKTMNVVAFVLLFFALIVTVGSKNWAKGRKGEEVTLSPQSWRPWTPLFIAAYDGGFGPGSSTFGILYYMKKHHTYLKAVQLTRVLILGSCVGGFLVFYQTGFFQWPYAVALAIGSTVGSQVGLLVLPKVPMKLAKGLLLTVTCLLILSIVYKLV
>NZ_CP012475.1|WP_035203479.1|2615491_2616391_-|LysR-family-transcriptional-regulator
MNLHALRIFTKVAALKSVTKAADALSISQPAVTIQIRNLEKETGLKLIKTEGRGINLTKEGEFLVKRAESLFNMEQDIENKLIQLKDGELQELHISSTSLPANYLLPTWLAKFKLAYPSVKINLSSGNSYQVVDQLLHYKSDIAFVVKEEWHHPTIQLHHLMDIEFWFIVPTGHKYDGQEVSLHDLMDEPFLVREEGSSTREVLFSLCNLHNVPVPNIGIQFHGLNESIRSVLAGYGAMLAPSLAVKDHIHRNELGKVLVKDIEIKRPVYLCTRKEDAHTIHLSRLIDLINGFTKDDFY
>NZ_CP012475.1|WP_035203463.1|2628358_2629066_-|GntR-family-transcriptional-regulator
MKKRQFVADDLLSKIYQNKYAPGEKLPTERALATHYQVSRYTIRKAIKKLINIGSVQVVQGSGMFVTKTIRESPLIYNSLTEKKFKDIQSTVIAMQKKKMTPEIENIFDMKNDFVWEFTRVRIVDYQKVQIETTQLPCSYFPDLTEQIAAGSVHEYVQQCGYDISHFITTYSAVNVTKEQANLLNCKKGIAAMKIVNRGILNDGRVFEYSELINLDYAVSYFTPFNRFKHQFRKK
>NZ_CP012475.1|WP_035203460.1|2629146_2630346_-|2-dehydro-3-deoxy-6-phosphogalactonate-aldolase
MEPNIITSIEAFVTNPHRHNFVVVKVKTNLGLTGYGCATFQQRPLPVKMVVDQYLTPLLLGRDAHDIEDLWQMMMVNAYWRNGPIMNNAIAGIDMALWDMKAKLANMPLYQLFGGKSKSAIAAYAHADGLTLEELFKNVDALIKRGFKHIRCQLGKYGGKNHDMHLPVRQLEGEYYDPDIYMRDVVRMFKALREKYGYSLHFLHDVHERLSPIQAIQLAKELEPYKPYFLEDVLPPDQNEWLAQLRAQCTTPIATGELFNNPMEWKHLIANRQIDYIRCHVSQIGGITPALKLGALCSQFGVKIAWHGPSDMTPIGVAVNTHLNIHLHQAAIQEIQEPEAIIEEMFPGSVQVKQGYIYPIDEVGIGVSFDETLAQNYPVVYRKHEWTQARLPNGAIHTP
>NZ_CP012475.1|WP_035203710.1|2630642_2631998_+|PTS-transporter-subunit-EIIC
MKDNELIPLIIQYVGGQDNIKKVWHCMTRLRFDLHDFSKIERDQIKELQGVVGEQLTNDQYQIVIGTHVQKVYAALTEELGLDEDKTSAEPAKKKGFFGAILDIVSGVFGPIVPAIAGAGMIKGILAGLIALDVLSNESDAVIILDLVASSVFYFLPFFLAASAAKIFKTNPYLALAVAGGFMYPSLLDAAKLGEVTQFSFMGLPVPVINYSATVIPIILSVWALSYINKYVDQYMPNVLRTVFTPTLTLFIAIPFALIATGPLGAYVGSLLASFIELLFNLSPILAGVVVGGIRPIAIVFGMHHAMTPIALQNFADNGFDMMMPMFLMTNMAIAGATFAVFFKSKSKKEKSVVLSAGVSALLGITEPALFGVLIKYKKAFIACTIASMAGATFFALLGVRIYGYILSSIVSLVAYVGPYFWFAILGIVLSIGIGFAVTYFTLKSKEVNSH
>NZ_CP012475.1|WP_035203455.1|2632465_2632963_+|hypothetical-protein
MAKKLGVAFLFVWLSAAVAGCGMFAAGGQEIEEKSKFEAGVKEPPIPTITIGNEPFQPALGAYSWGVENSSGTVTSTEVDIAPPPEQAKHMESIAVAGEDDLEIDFGSVHPPKPMDLHIWEDGKRRFVDGDMRLADYKGTGSVIVELYGEWHEGHASYVFVLEVR
>NZ_CP012475.1|WP_035203452.1|2633130_2636094_-|response-regulator
MPTKKQLLIVCVFLLALLIIRLVWNAMTGLPDQPTAKNGVLDLSDFAFSQPGYVSLEGEWKFIPLHSEEQALKTIPGPTELELQGTYQLDLQVQDTERYYGFYIHLPHGILSVSANGQRLYQTSTQNRQMSPTVLASIQPDENGLIRLTFQLEEIDRHSWLPTPRSLYFGPSENIERKNAIESLLQMAVAAIMLIHAIYACILKAIKPAKKGILFFALAAFFAAASVLISDNKVLGYFIALNSEWDKRLTYLFYAGLSLSFLLFVLRTFAPSYKRTVRVASTLFGLYFVYLLLVPLSLLHKTGFLLAVAIVFAFSTITFIMLKIVQAQLKGALLLYLAALAVASNVLWMMLYRYVDSVAMPTLMFYPVDLTVAFLCFSSFWFLRFFHAEDENATLLAKLQREYKQKDQFLASTSHEMRNPLHGMMNIAQTVATENKQVLDQKSQQSLELLVSIGRRMSYLLNDLIDLAVFKERKLTLQQEAIQLEPIIRRTLDTLNFLIDNEKTRFVVAIPNDFPLVFADANRVSQILFNLLHNAGKFTNEGTITIAASHSGKLATIRVIDTGLGMDQSTKARIFEPYEQGANADNEGLGLGLAICKELVEMHGGQINVVSSPGQGSSFSFTLPLAKSANHQAIATALTTEQPNEVAAAEAPQQPEREAPFRILAVDDDPVNLKVLRHALSTKPYQLVTETSPKATLRKVAEERWDLVIADVMMPEMSGLELVKHIRQTYSVSELPILLVTARIQPEDIYAGFRAGANDYIGKPVDLLELQTRIEAMLALKQSIEDRLRLEAAWLQAQIEPHFLFNTLNTIASLSTVDTDRMLDLIAEFGRYLRASFNEKKLSPVIPLSEELDLLRSYLYIEQERFGERLQVKWAIDEHVDCLVPPLSIQPLAENAILHGILKQEAGGTLEVHVYKKDGKAHIAIKDDGVGMDQDTLNTLFTQTKSTKKSIGLANTNLRLQKQLGNGLSVSSEIGKGTTVSFTAPLQ
>NZ_CP012475.1|WP_051881181.1|2636167_2637286_-|response-regulator
MKAVLVDDEPHALTFLENQLLGVGDVEITGSFTSASTALDWVLSTPPDLLFLDIEIANVNGMELAETVLSKHPDIQIVFVTAYQEYAVKAFELNAVDYIMKPISKNRLKKTLERLQTKKQQESIPAEKTTICCLPSLQFFSGEKPIHIHWRTSKAKGLFLFLLHHLGHHVRKDVIIETFWPDSDYKKAYAQLYSTVYLIRKTLTSVFPSIRIDNFEQSYTLEVGDIHIDYLEWEKKWSQLPALSDSTLPAYLTLLDEYRGDYLHEEDYLWAENRREHLKNLWRETATAVADYLFEQGRYEQAARLGQKIQEMYPFLEESYCMLMRIYAALNEPFYFEKQYNKLVHMLDEEFAIAPSPELIKLHDECRKQLTE
>NZ_CP012475.1|WP_051881180.1|2637489_2644791_+|LPXTG-cell-wall-anchor-domain-containing-protein
MKNKATAIVLIFVLLVQTFIAQLAGAVQVYAQEPEASTFEALASLVDENGEPLTEEATLAAEDQVHVKIDWSLTGHTQQETYHIKLPEQWQPDKIEWKDEGHGDEMVTYSLNGTELTMSFPEQEEAVQASGTVELSAYFSQDAIGEAAETDLVFLIGDTAQVIPVSFQVKEELEQEPVQEEAPASSEEEQVNEEGDTPESKEQAPETEKEEETPVVDEEQVAAEEKQEDARKEEQEEASKEKEENVEANDQEADTTESAEADVVSQAVVGEIEKNIITGIVLRDGDGNLINADENPGNKPALGDDVQIEITWELPNGHGYGSGSTFTFSLPDIFHVYNDVNGELTFGDTTVGSFTLKEDGTVVMTFNEQIEELSNVHGLLNFRTIIREDLVGDVDREVVFDVKDEVVANIPISLQPKAGSAIDKRGQVNRAYNATEIEWTVDFNKQLKSINQAVLKDPIQQHQALKKGSIEVYKLDVQLDGTVKQGERVDPSAYTVTEDPFDIQFGDISSAYRVVFSTEITDEDGTNYANKATLTGKNSEDLSAEASVTTRRGQALAKRNASYDPATQTITWEIHYNYNEKSIKQADALLVDSFSESHDLIADSIKVERITLDENGNEKEASNADNYAVTPGQHGFELKFTEDINDAYKITYKTKANERVLEDGKIDNIVQSGGREAKGSQGTSQQVLHKGYSNINYKDKTVQWRIDFNRDGYEMKDVFFTDTFTNGGLELERDSFKVLRKGTEVDPSEYTLAETDEGFTLRFHEPISEPHQIVYTTKFHYDELKGDQFRNHVHMKWTTEDGKTWEKEASSGFKPDTYTTNNGFKNGSYNAVTKEITWTVGINYDLKNLTVMNVTDYIKGKQTLVEGSIEVYRAELTGGNNGIRKGEKLSPSEYELDLLSDEKPGFHVRFPGERDDAYIIEYKTSVEGELIVDRYDNTATLSSEGREPVDLNAHVTVQHGGSYVKKAGKQNGNVIDWNVAINAGQSKVSDAKVIDQQQANQILLEDSFRLYATTVSGNGQFAKAEELERDKDYTLEINTADDGSQTFVLSFLEDITRPYILEYQSYINASDGEEISNTIKFEGKQITTERTDSSETIKVRLTDGGGSGSGKRGSLEVIKVDANSKEVLPGARFTLYDKEGKIALRTVVTDEDGKAIFRNLRYDDYLLKEDSAPDGYVVGIDEKIVKVDSETTTITVENKKITRDVALTKVDEETKQTLAGAEFALEKKAGDNWETIEEGLVTNEDGQLVLTELEPGDYRFVETKAPVGYELDNQPIEFTIDDKQTERILLTKDNVIIKGSAVLKKVDAATGEPLEGVSFKLVQDGKTIKEGLVSDKDGFVKVSGLRPGSYELIETTALENYKLDPTPIPFEIEAGQEKELTIGEKENALVTGGIRLTKVDGDDNRLALQGAVFALLDEDGNVLREGLETDESGQLTIEQLAPGNYQLVETKAPVDYELDDTPIPFTIEKSQQETIQVERKVENHLITGAVELKKQDSKDGSALEGAEFSLYTEDGELVEEGLVTGENGTVYVEGLKPGKYYFVETQAPAHYQADDTKRPFTIERSQLEKVELIVENVLIPGAATLIKVDEDSENVRLEGAVYTLEDEEGTVIEEGLTTDEEGRIVVTDLPPGVYYFIETKAPEHYQLDNTPIKIEIEKGQQEAVQVKAVNTLTTGSVVLEKHDSESNALLEGAEFSLVDENGNTVKEGLTTDANGRIVVEGLKPGKYAFVETKAPADYQLDEKPIPFEIVRSQKEALVVEKSNTLIPGAVELLKVNQHDTAETLAGAEFTLLDGEGNVLEEGLTTDEEGKLRVEQLAPGTYQFIETKAPQGFELSSEPLPFVIERSQQETLKVTAFNELIRGKVELSKVDSDNQTIALKGAEFELRTKAGEFVALFTTNDEGKLLINGILPGDYVLVETKAPFGYQLDATPINVTVERDQKTAVLVTKENTLIPGSVIVEKVDAADQQLLLAAAVFSLLDEAGNVLEENLMTDQHGRLEINNLPPGDYQLVETKAPEHYQLDATPIVFTIEKGQTVTPVITVENTLIPRAAALIKVDQDNGDIRLAGAEFMLTDADGNVVAEQLVTDENGLVAVSDLAPGTYYFVETKAPLHYERDAEPVAVTVEKGQTEAAVVKKSNTLISGAVVLEKVDSSDHSTLLAGAEFRLEDEQGTVIQEKLVTDETGRIIVTDLKPGNYQFVETKAPNGYDLNEEGLAFTIERSQEAAVVVKAENTLTPGSVEIVKVDSSDGARLEGAVFTVLTEDGDMVAEGLTTDESGSVQLDGLAPGTYQLVETKAPAHYQLNETPIAFEISKGQTERLVLTVENTLIPPGEEPKEPQPPSEPKQPLTEPGDGQTPTGPQNNNGGTGTGKTGTPKAGGGDPSPLLSKGAQPASGGQLPQTGETEMFMFMVAGLLLMAIGALTLVNGRLARKRG
>NZ_CP012475.1|WP_011248403.1|2644807_2645398_+|class-D-sortase
MRKRTLFIGMLLIIAGLALVAVPLTKEWQQANGVAQLEKALAAVQTGETIEKTDDSPSSWTKEQLEAVMELEIPAIDLKQYILDETTDENLALTLTQIKQEQVPGEGNFAVAGHRGYRGDRHFRQLPNVQKGDEIRLHADDGKTYIYVVKSTEIIEPTDVDVLNDGEQPEITLITCTLSGQQRVAVKGDLIDVIEA
>NZ_CP012475.1|WP_011248401.1|2645705_2646044_-|helix-turn-helix-domain-containing-protein
MAELNDRLRELRKAHQLTQQEVASFLGITESAYGFYEQGRNEPSIAKLKQLAEKYNVSIAYIAGETDIKTAPSDKVKENGSAYTFTNLDEEEKEFLGEQLELFRRLKKKKGH
>NZ_CP012475.1|WP_035203450.1|2646321_2646576_+|hypothetical-protein
MADIPYSVCSCLYTGIQKSIAFLTMQANAVQASKECVWKRYDDQLYHEVKEALQWHRQHCMADTSHLEEALRVFENAYNQVHDK

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Crispr_ID: NZ_CP012475_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_13

2692566-2692919

Orphan

I-C:NA

Consensus_repeat	Method
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	PILER-CR
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCACTCTTTGTGAGTGCGTGGAT	CRT

5 spacers

The CRISPR arrays of NZ_CP012475_13

>merge|NZ_CP012475|13|2692566-2692919|PILER-CR,CRISPRCasFinder,CRT
GTCGCACTCTTTGTGAGTGCGTGGATTGAAATTTAAAATGTGGCGTCCTAGCGGCGCCTTATACACGTCGCACTCTTTGTGAGTGCGTGGATTGAAATGCTAGTTTAGCTCGCTCAGACAGAGATAGAAATACGGTCGCACTCTTTGTGAGTGCGTGGATTGAAATGAATGCTGAAAAGTAGTAATTCCAAGCGGGTAATCGTCGCACTCTTTGTGAGTGCGTGGGTTGAAATTCCTTCTGAGGCTGAACAGCTGGCGTCTGCCATGTCGCACTCTTTGTGAGTGCGTGGATATGAATCGCGCTCTTCTCAGCTGCCAAACGTTGGTAGTCGCACTCTTCATGCGTGCACACAT

>NZ_CP012475|13|11|2692566-2692798|PILER-CR
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	TTAAAATGTGGCGTCCTAGCGGCGCCTTATACAC
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	GCTAGTTTAGCTCGCTCAGACAGAGATAGAAATACG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	GAATGCTGAAAAGTAGTAATTCCAAGCGGGTAATC
GTCGCACTCTTTGTGAGTGCGTGGGTTGAAAT

>NZ_CP012475|13|13|2692566-2692863|CRISPRCasFinder
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	TTAAAATGTGGCGTCCTAGCGGCGCCTTATACAC
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	GCTAGTTTAGCTCGCTCAGACAGAGATAGAAATACG
GTCGCACTCTTTGTGAGTGCGTGGATTGAAAT	GAATGCTGAAAAGTAGTAATTCCAAGCGGGTAATC
GTCGCACTCTTTGTGAGTGCGTGGGTTGAAAT	TCCTTCTGAGGCTGAACAGCTGGCGTCTGCCAT
GTCGCACTCTTTGTGAGTGCGTGGATATGAAT

>NZ_CP012475|13|11|2692566-2692919|CRT
GTCGCACTCTTTGTGAGTGCGTGGAT	TGAAATTTAAAATGTGGCGTCCTAGCGGCGCCTTATACAC
GTCGCACTCTTTGTGAGTGCGTGGAT	TGAAATGCTAGTTTAGCTCGCTCAGACAGAGATAGAAATACG
GTCGCACTCTTTGTGAGTGCGTGGAT	TGAAATGAATGCTGAAAAGTAGTAATTCCAAGCGGGTAATC
GTCGCACTCTTTGTGAGTGCGTGGGT	TGAAATTCCTTCTGAGGCTGAACAGCTGGCGTCTGCCAT
GTCGCACTCTTTGTGAGTGCGTGGAT	ATGAATCGCGCTCTTCTCAGCTGCCAAACGTTGGTA
GTCGCACTCTTCATGCGTGCACACAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_073305390.1\|2703695_2704970_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP012475.1\|WP_035203373.1\|2686990_2688451_+\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271357
NZ_CP012475.1\|WP_035203383.1\|2682382_2682880_-\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|341130
NZ_CP012475.1\|WP_035203349.1\|2705832_2707035_+\|glycosyl-hydrolase-53-family-protein	unknown	unknown	gnl\|CDD\|226385
NZ_CP012475.1\|WP_035203351.1\|2704969_2705812_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226354
NZ_CP012475.1\|WP_011248364.1\|2693076_2693886_+\|TrmB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224296
NZ_CP012475.1\|WP_035203385.1\|2681341_2682298_-\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|366736
NZ_CP012475.1\|WP_035203370.1\|2688547_2689753_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224747
NZ_CP012475.1\|WP_035203381.1\|2683015_2684212_+\|erythromycin-esterase-family-protein	unknown	unknown	gnl\|CDD\|350610
NZ_CP012475.1\|WP_035203700.1\|2689702_2690593_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP012475.1\|WP_035203359.1\|2695919_2699399_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_011248358.1\|2702375_2703635_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270376
NZ_CP012475.1\|WP_035203364.1\|2691718_2692378_+\|ABC-2-transporter-permease	unknown	unknown	gnl\|CDD\|379133
NZ_CP012475.1\|WP_011248363.1\|2693965_2694832_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP012475.1\|WP_035203367.1\|2690864_2691722_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP012475.1\|WP_142237576.1\|2699422_2700868_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_011248359.1\|2701193_2702186_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380486
NZ_CP012475.1\|WP_011248362.1\|2695048_2695603_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035203379.1\|2684476_2686231_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NZ_CP012475.1\|WP_035203376.1\|2686227_2686974_+\|3-oxoacyl-ACP-reductase-FabG	unknown	unknown	gnl\|CDD\|235500

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_073305390.1\|2703695_2704970_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.15825e-78
NZ_CP012475.1\|WP_035203373.1\|2686990_2688451_+\|sodium:solute-symporter-family-protein	gnl\|CDD\|271357	cd10322, SLC5sbd, Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain. This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.	1.4397e-62
NZ_CP012475.1\|WP_035203383.1\|2682382_2682880_-\|L,D-transpeptidase-family-protein	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.68708e-39
NZ_CP012475.1\|WP_035203349.1\|2705832_2707035_+\|glycosyl-hydrolase-53-family-protein	gnl\|CDD\|226385	COG3867, COG3867, Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism].	7.20059e-151
NZ_CP012475.1\|WP_035203351.1\|2704969_2705812_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226354	COG3833, MalG, ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism].	7.83752e-127
NZ_CP012475.1\|WP_011248364.1\|2693076_2693886_+\|TrmB-family-transcriptional-regulator	gnl\|CDD\|224296	COG1378, COG1378, Predicted transcriptional regulators [Transcription].	2.1466e-28
NZ_CP012475.1\|WP_035203385.1\|2681341_2682298_-\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	4.1971e-14
NZ_CP012475.1\|WP_035203370.1\|2688547_2689753_-\|hypothetical-protein	gnl\|CDD\|224747	COG1834, COG1834, N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism].	1.16717e-45
NZ_CP012475.1\|WP_035203381.1\|2683015_2684212_+\|erythromycin-esterase-family-protein	gnl\|CDD\|350610	cd14728, Ere-like, Erythromycin esterase and succinoglycan biosynthesis related proteins. This group contains erythromycin esterase, which shares conserved active site residues of the Tiki/TraB family. Erythromycin esterases (EreA and EreB) disrupt erythromycin via the hydrolysis of the macrolactone ring. A critical catalytic histidine acts as a general base in the activation of a water molecule. Macrolides act by inhibiting bacterial protein synthesis by binding at the exit tunnel of ribosomal subunit 50s, blocking the translation of the polypeptide. Erythromycin esterase, typically found in integrons and transposons, confers antibiotic resistance through the disruption of the drug ring structure. EreB substrate profile is substantially broader than that for EreA, being able to also metabolize semisynthetic derivatives such as azalide azithromycin.	2.90988e-58
NZ_CP012475.1\|WP_035203700.1\|2689702_2690593_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	7.67067e-36
NZ_CP012475.1\|WP_011248359.1\|2701193_2702186_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380486	cd01544, PBP1_GalR, ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism. Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism. Transcription of the galactose regulon genes is regulated by Gal iso-repressor (GalS) and Gal repressor (GalR) in different ways, but both repressors recognize the same DNA binding site in the absence of D-galactose. GalR is a dimeric protein like GalS and is exclusively involved in the regulation of galactose permease, the low-affinity galactose transporter. GalS is involved in regulating expression of the high-affinity galactose transporter encoded by the mgl operon. GalS and GalR are members of the LacI-GalR family of transcription regulators and both contain the type 1 periplasmic binding protein-like fold. Hence, they are structurally homologous to the periplasmic sugar binding of ABC-type transport systems.	1.11054e-101
NZ_CP012475.1\|WP_011248358.1\|2702375_2703635_+\|extracellular-solute-binding-protein	gnl\|CDD\|270376	cd13658, PBP2_CMBP, The periplasmic binding component of ABC transport systems specific for cyclo/maltodextrin; possess the type 2 periplasmic binding fold. This group includes the periplasmic cyclo/maltodextrin-binding protein of Thermoactinomyces vulgaris ATP-binding cassette transporter and related proteins. Cyclodextrins are a family of compounds composed of glucose units connected by 1, 4 glycosidic linkages to form a series of oligosaccharide rings, and their cavity is hydrophibic which allows cyclodextrins to accomodate hydrophobic molecules/moieties in the cavity. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.54599e-144
NZ_CP012475.1\|WP_035203364.1\|2691718_2692378_+\|ABC-2-transporter-permease	gnl\|CDD\|379133	pfam13346, ABC2_membrane_5, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	1.56712e-26
NZ_CP012475.1\|WP_011248363.1\|2693965_2694832_+\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.03897e-15
NZ_CP012475.1\|WP_035203367.1\|2690864_2691722_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.67846e-70
NZ_CP012475.1\|WP_035203379.1\|2684476_2686231_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	4.99003e-59
NZ_CP012475.1\|WP_035203376.1\|2686227_2686974_+\|3-oxoacyl-ACP-reductase-FabG	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	1.24493e-91

>NZ_CP012475.1|WP_035203364.1|2691718_2692378_+|ABC-2-transporter-permease
MKGLVLNQYYSVGKSFWNYIALSVVITAILLFTQNEMLMQFAAWLPLFFMVTPALEVLKHESMSGWSKFVLTLPLKRREVVQSHYLFYSMMIVIGIVITVALFMVADSLIGQVMTDSAVNKIMNGVGIVLISGLLNYPLTYLLGTEKSDGILVFSIMAAVGLFLLSSWLFEIFLGAVSFDALQGMNLDKLFSGSFLAVTFVLFMASYVIALQVYKRKEF
>NZ_CP012475.1|WP_035203367.1|2690864_2691722_+|ABC-transporter-ATP-binding-protein
MSFILEVDNLRKQYSDSAFALKGVSFSIPYGSIVGFIGENGAGKSTTMGSILGTLQKDSGTIHIFGEEMAPDKLHLKENIGVVFDDIKLPGDLNIVKLGNVFQRIYKQWNQKTFDHYVDFFSLPRNKKIRGFSRGMSMKLSAAVALSHDAKLLILDEATAGLDPTGRDELLDVLKGFVQDGKRGILLSSHITSDIEKIADSLVFIKNGKILLNVKKAELREKYAILQCRQNEFDLIQQKLILTYKKNEDTVDVLVSDREQVPSSITKKDFTIDDMTLLLMRGETA
>NZ_CP012475.1|WP_035203700.1|2689702_2690593_+|helix-turn-helix-transcriptional-regulator
MDYNKSIQTSIAYIESHLQDPISVADVAKKAGYSPYHFHRVFLQEVGLSLSEYIKRRRLCFAAKTLLHTDTPVIEVAFSCGFESQEAFTRAFKRLYGLPPARYRTRFQPHQFIQANGGNMMDLQTSPIKHWFLSGSQPAEYEYGLDTETVHQGSVSAYLKSYALQEEDDFATLMQQFNAKNYVGKRVRFSGFVKTKNVTNYCGLWMRVDNNMNDALQFDNMSNRKIVGTTNWNRYAIVLDVPENSAVISFGLLLSGKGQAWLDSCSFEVVDKKVPSTNIEMNFTMYDEPLNLSFQE
>NZ_CP012475.1|WP_035203370.1|2688547_2689753_-|hypothetical-protein
MALNVGNARLDAFVVIDRPPPSRPFIIANRLFFFLIQIAQAWAISLPFILRITAFSFVDTRKRSLNIKERCYLPLPSNHLPGQRLVVDSFYDIDAQQAVWGGLWGAFSPVGPIQKVLIHRPGNELRQLDNKSYETYIDDQILQDNQGVIGNDLTGTDPIDVALLHRQHDQLRQALLDSGAEVIDLDFVSPNHPKSIYVHDLGLVVPGGVILPRFALGIRQGEEQAAYRTFAKLGMPVLATIQGNGFIEGGSFTMLDERSAVVGRSVRVNQAGIDQLRTILAWQEMELIVVDLPADRIHLDELFMLVDTKTALVEPKRLPYWFLKELRSRGYRLIYTDPNDPDRAANCLTLAPGHVLIASEYPGTIKQLQQAGIRTKTIDTTEIRKIGGGIHCAALPLVRGQ
>NZ_CP012475.1|WP_035203373.1|2686990_2688451_+|sodium:solute-symporter-family-protein
MEGIIIFLIYLVFIYYMGYKGYQRVKTAEDLIVAGWSMPLYVVTGSLVAALLAAPFFFAAVGSGYTSGGFEGTATMAGLGTCMILGALIWTRPLRRLRGWTIADYYGLRFASKKLGAYTGSVMAVAFGFFNAGALTVGGTYVIQTIFAIDFIPAACLFVLLTVVYSAIGGLWAVAYTEIVQGVVALIGILGIAGVVLFTHGDLTFQPDWWNVSNLFEKGGVEFWALYLVLALGDIPAADLGQRVAGAKSPRVAYLSMIIAGVIVISISWIPGMLGEAFKTIFPNSDNPEMLMIMFADGYFPPIISAIFLTSLAAMGMSTLAACYVASAGIWTKNIYLDLINDQPDPKKLLLFSRIAICVSAALGLLLALGFQKVIDLAYLAWDVVFVTLFWPIVLAPFWGRVSTKAVWASVTLGLLSYGVTTFTGVPGPEVASTGIIGLLVELWHLPVFFGVVISGLTIVITSLVSPATPEVRNMHELEKIPTADE
>NZ_CP012475.1|WP_035203376.1|2686227_2686974_+|3-oxoacyl-ACP-reductase-FabG
MNALKGKTAVVTGASKGIGRAVALELAKAGADVLVNFIGNPEEAEEVCAIAASYGVRAMKWHADVSDPQQVRDMYALVDREFGKIDILVNNAGIAEEAPIIDMTDEGWDRMIRVHLYGTFHNCREAAKRMTEAKAGKIINISSDLGHLGCENFSHYSAAKGAINAFTKSLARELAPHVLVNAVAPGGTWTDILASFGDDYAEEEAQKYPLKRLAKPEEIAKSVLFLASDDGNFYTGQILGPNGGAVMP
>NZ_CP012475.1|WP_035203379.1|2684476_2686231_+|methyl-accepting-chemotaxis-protein
MERISQLSLRHKLAIPIVALVIICFVILTWMSQSTLSDQLHRDLERELRSVGLLTASSLDPSDVEAVMGVTDETDEAFVHLQNQLETIMEKQGIMYWSYIWQMEGDSVIPLGFTKNLEDVYNVGESFDNLASIHIEGGHQAIESGEPVVTDVFEDDFGTWSTVFSPIENEHGETVAVIGIDYSAEYIDSILGELQLSQWLTAIMGTLIVACFVYFVVNGLLKPLKQVVQVTNKVADGDLAVPSLEVRSKDEVGQMATALNQMVQSLRGLIQNMAYASEQVAASSQQVAAASNQTEQAANEVVAVMGDMAEGARVSQQAAEDTAKATEENAQGIQRIAQSSAVVAESAQKTAAEASQGNDIIQNVVKQMQSVSSSVNQAGKEVQELGERSSEIGKIVELITNIANQTNLLALNASIEAARAGENGRGFAVVAGEVGKLAEQSAASAKQITDIIAEIQTVTERSVESMATGTKDAEEGLASVNEAGEVFQRILGAAQQVAAQVEEVSSVSEQLSANSEEVAASVQELTGFAEETTNRTDNVTTVSKEQLAAMKEIAASSDSLTQMAEQLQESMNQFKLEQQKDVLE
>NZ_CP012475.1|WP_035203381.1|2683015_2684212_+|erythromycin-esterase-family-protein
MVNKFADKRTEWKEQINEQLIPLDEGEWKQLDRFLEGKQIVLLGENSHWVSEYYTNKIKFVQYLHEKHGFRVLVLESGLVEASTTDFFGNTNLEDAMKNGLLGIYHNEEMTTLFTNEGLEDLTIAGMDVQPISNDCSQRILSCVEKEIGGHVANKLKDVEATFFELEPQIRNEVKLAKDTKKQLKQLAEGYEEVISLMENEMQAGVYSKRLQLIYRGIVNRKQWLLVNLKGRFRSGSLRDVFMYENLEWLFDYYKGEKIIVWSHNYHIRKNRSLLLKGLGIKTVGHLLAKQYAHSLLSVGFYAGSGTCLSPYKQPYDISVKNQYHLEKLLMEFNRDVLFLPVNVDAIGQKRPWSKQNWWLLEMKWLGMAPLVIKPYKFYDAIFFVKRVNPPRYWEDQD
>NZ_CP012475.1|WP_035203383.1|2682382_2682880_-|L,D-transpeptidase-family-protein
MFFHSVQQGETLSSIAADYRISLSHLIQANPTINPNQLFVGQSIVIPGLPNPNTIPYEIHVSLSQHQLTLLHNGSVVKIYPIAVGKMLTQTPTGNFVIVNKAPNPGGPFGTMWMSLSKLHYGIHGTNDPSSIGKSVSHGCIRMHNEDVEELAATVPIGTRVRIEP
>NZ_CP012475.1|WP_035203385.1|2681341_2682298_-|aminoglycoside-phosphotransferase-family-protein
MDSLKRLLQEQYQLQAQTISPQKGGWAALAYRVETKKHTYFLKMYEKSRTSTPKWTALIDEYVPALIWLNEQNDLNSKVPVPILTKNGQCKCENDKGIFLLYEHIEGETIGPQQLTNGQVEQLATIIAALHAIGEETAPIATAQLKEDFSLPFAVSLYKLLTEQLAMLPDDIQTTIAPFSQPLLSLIESTEKRANTLKQRPLRYALCHTDLHHWNLMTSQGELVLIDWEGLKLAPVEADRMFVVDECYNNAFMDHYRKHHPDYVIDQECLAFYQGRRKLEDIWEFLEQLLFDEQKPTERAAILEGLEKELEAVAKACL
>NZ_CP012475.1|WP_011248364.1|2693076_2693886_+|TrmB-family-transcriptional-regulator
MEEAVIQELQKHGFSKYESKAYIGLLKAPAITGYELSKRSGVPRSMIYEVLGKLLDKGAVHTVPADPIVYKPVDPRQLLTKMREDLDASLTSLEDSLTTLESDQKIDVVTRIVQYDHIISEMRSMIRAAKKELWLSIWSPTVASIEDVLKEKETDIPIFTVLFGDESKSFGHTYHHNYMAPNIVSERMGGYLTIVIRDEEEALIAKFSDKGSEWAVKSMDPALVLIATEYIRHDIMVEEVTNAFGPEKLDALWRKREDLIHVMTGKSSL
>NZ_CP012475.1|WP_011248363.1|2693965_2694832_+|DMT-family-transporter
MNAHVKFSLAMAIFGSIGLFSVKAGLPSLELVFVRCLCASVMLGAVLLLTNRKGREERPPKSEYGKVLLCGLFLVLNWLFFFRSFEVMPITVAVSIYHLAPLLILLLGSLLFKEKLTWAGIASIVICFVGALLVGKAYSHGHVSDFLQTGIGWAFAAAFFYALTSLAGKSITVLSPTKTTLIQTMLGAVLLAPLVDWHLFSGLSAENWLFILITGFIHTGVVFYFFFSSLRELPASTIAILVFIDPIVAILLDVAVLHYRPDILQLVGILLIFLAMGYRPKKYEQKKA
>NZ_CP012475.1|WP_011248362.1|2695048_2695603_-|hypothetical-protein
MNYKELDARSKHLKPVKLNRFQIEHTLERKYEAKELPLFTIPRKDYENDEEVDEKRIYKLYTITNKQVLKQIQNKDDIDAIKEPFLSTIYEKASYIVSQTKSKNDGQSVSYNQLIHEHNHGKRVSVVLEKDETDYVTNFKVYGFAHHLVTYLVARIGIEGMKEGDMTDTDYQFYLECLAENGFI
>NZ_CP012475.1|WP_035203359.1|2695919_2699399_-|hypothetical-protein
MGVSRYSIQSTLMKSYVSGTPLQYDKALTTTTGTDGQLWLFSIGSDGLIYLYSKENGTDKGWNTRYLSGGLPEHSEAVFIEAIQDADGAPLLTAVVLKEQTYTVYMTKDFSDHTKDRWLFRGQYSGGTVSNIATGYGKQGQVFIVVTTQDKDRSSNHLINPNLTDTTWLWREVPAPLNSKHVIQTAIGHHNKLESINGVDGLLYALYQTSDKQTQLVITSLPDFHYYNHPVPLDFSPTSFALVTAPGSNSECWLGDTSVYYASPAVQLAKDAKTVKAGLRKIDGNPSKRPYKQILAARTNSGTDIWLLTDDGKLSRSHFDETSWTEPLLFQEQVGESALWVNRTTGENHLVVVDLDNQLYRYFQDVSTTRWHSEQILFESLGTIEEKDGYSTVIQLVDDKGAPAVNETIWVQASELVQLTINGKTYFATDRPGYIEANTDSLGNVMITQYVKSVAAAALRITIPALNETIDIEPLAQVKQKLTGMTVDEWINAEMQTDQDGVTEPLLKGKSKQDIADTHQAVQRLLTMAQTLPSHKQGPFQTSSKHIPLANTLSLAHVEDSMHWGLDLTGKHPVYTENKGHIDQHFNPRAHLLNQTKDTAHILSDWFGDIWHAIKQGFITVTHFVFSKVKEGIELVINSAEKAYRVVLRYAEQLWDVIEYVFAEIDILLDDFVRWLGYLFKWKDILRTHEVIRTTVELGIKETVQKLDQGKAFVDRLIEHVQRNIADPALQENIGAFGSRTLTEQEYGQQLLFEAPEANWSMNYVMSGHLLKPGGNLPEVDTLAYDESWGAGLESVKQQFEQFGTELASQFESWSFATLFQKIISLLEDAVLEGVKLLADGLFTAAEQITQMVDDLLHIHWNVPLLTPLYEEIVAPGSKLTLIDFISLLTAIPATVLYKATTGDVPFEEETTTQLVNSQSYGDFLAKLGGKQPHLALDQEQSPVLLQAAAEPEVPIAARKASYAFGFIGGIASIIAGTASTTMSFTETTTIGCAVVFLSYSVGTATSVTTLSLDLAYKPYEKRLGFEMFYALFQIGFNLKDGLALGNQIKNKGIAKLAYELLLDLGETLLGAISCAFSIALAIWEGVDGEMTTSNGMKLTQNLAITISQILAFPASVISEPRVKKVIQGAQAFCNISPGVIDICRTAYDQEMEAIHTNR
>NZ_CP012475.1|WP_142237576.1|2699422_2700868_-|hypothetical-protein
MLTYQNLNGFDMVYAVSQQTINAQLQLLWAMDMLPTTWKAEAAEGLYSIDAELGCPVVDFNTGDSSSRTAKLTMPLTKASFHYAKIVIEDGKPTVVQTTKEISGSSLSFFVNMSLAELASTYQNQDSIPDEVKRQLEQFDTSMFSIQHLFLNFEDANLLKSFDFQTNGAIPTDQPELTGQIRNLVEAFIDTIKGNDNPYIFGYYAVDKISEPSQATWQPTGCTYSIYSDAHFASRSSINYLLVTDHKTVPGSGAGMFQHNWVMSDQVEGSFVLSQALVMDPLLQSLANMLSIDKTQFSPTNNNQFFVSFESRLDKNTKGKTTCTLVPLVGTKQMAVYFNIDYNTDMHDLAGSYIGYVDGTIKWTTTLTFEVDTIKSSVNVSAKNSEVITTKKDHPNALGKFEHALAVFADFIITVFTFGQVDDVFQDLIRKDWQKTINTGYSTQINSMKARAILPGGSEIMFKDAQFYENGSMIVATTVKN
>NZ_CP012475.1|WP_011248359.1|2701193_2702186_+|LacI-family-DNA-binding-transcriptional-regulator
MATIKEIAEKAGVSITTVSRVLKQDPTLSVTQETREKVYETAQRLGYTKKRFKHSLKKIAFLYWITEKEDLQDVYFQTVKKGVEEEANERQLNLTTYSIGDGIEAIDPQTKGVICLGRFSKRELDYIRTLTNDVVFIDTSPDEDHFDSVRPHLRRMIERMIDYYLENGHTAIGYIGGNDFDADCGGYIPDRRERAFKEYMEKKGLFDERFLFVGDQYAVNEGYALMKRAIHSLGDQLPTAFCVASDSLAVGCLQALNEERIALPERVNVFSINDASIAQYVSPPLTTFRIDVKLLCQTAIDLLLERLVDKRTSPKTVLMSCNPIFRKSTG
>NZ_CP012475.1|WP_011248358.1|2702375_2703635_+|extracellular-solute-binding-protein
MKTNWRMVLLSGAVLTVVACGPQEDGDAGESASGTSADKLVIWEDAEKAIGIEKAVAAFEDMHGIEIEVIEKEYGGQLEDLRLDGPAGSGPDVLTIPHDQIGTAVVEGLLAPLEVDDEVTGRFTEESLLSQTVDGEVYGLPKAVETTILFYNKELVDEPPQTLDEWYELSKERVAEDEYGFVAKWDEIYYAMSVIGGGGGYIFPQNEDGQYDVNDIGLANEGAIEGGTYIQTFFEEGLFPAGIVGEQGINVLDSLFTEGKAAAVISGPWSFEPYARAGIDYGVLPLPALADGEPMSSFLGVKSYNVSSYSQNAELAQEFVEFLTNEENSLDRFEQTREIPPLTSLVEHPAIAEDEHAAAVSEQSLYATMTPNNPEMAEVWTPIDNALGLIATGRTDVQEALEEAVQTIESQIEANHSQN
>NZ_CP012475.1|WP_073305390.1|2703695_2704970_+|sugar-ABC-transporter-permease
MKPATNHALVAGMLAIIPGMGQMYNKQFAKGTLFFLFVAAFLFVFKDIFNMGFWGLATLGVQTPRDNSVFLLAEGIIAVIVAAFGLAFYYFMIKDAAKNGKRRDLGLELHSIRRQYHHLLDASFPYLMSSPAFFLLIFTVIFPILFSLAIAFTNYDLYHSPPANLFDWVGLKNFRDIFSVPIWRSTFLDVLGWTVVWTLVATTLQCALGIFLAILLNQRDVRGKAFFRTFFILPWAVPGFVTILVFAGLFNDSFGAINNHILTFFGVDGLPWLNDPFWSRVALIVMQMWLGFPFVFIMTTGVLQAIPNDLYEAATIDGAGFIQKFRLITLPLVLYSIAPILITQYTFNFNNFNIIYLFNGGGPPMPGSTAGGTDILVSWIYKLTMQSSQYALAAAITMLLSIFVISIALWQFKRTNSFKEEDMM
>NZ_CP012475.1|WP_035203351.1|2704969_2705812_+|sugar-ABC-transporter-permease
MTVYTKRRIRLFVTYSILVSVVLVIAYPLVWTIGASFNPGNSLMSTSMIPENPTLAHYIHLLGEGSHPYVQWYLNSLKISLLTMGITLVLVSFSGYAFSRFRFKGRKNGLMLFLLLQMIPQFSALIAIFVLAQMLGLINSHWALVLIYAGGQIPMNTFLLKGYLDSIPRDLDESARMDGASHFRIYGQIIMPLAKPILAVVAINSFTGPLGDFILASVIVRSPEMYTLPIGLYNLVSNPMGASYTMFAAGALLISIPVALMFLLLQKQFVSGLTQGGVKG
>NZ_CP012475.1|WP_035203349.1|2705832_2707035_+|glycosyl-hydrolase-53-family-protein
MSLRGKWPFVVLLVCIVLFGGADVKAAVTVEPIAGLDDRFIKGADISMLPEIEENGGRYYADGEQIDPLVLLKEKGVNAVRIRIWVDPYDENGNPYGGGTVGEQRAVDLAKRAHNHGFQLLLDFHYSDFWTDPGKQFKPKSWEHYSFEELKSAIYHHTSNVLGQLKDAGIIPEMVQVGNEINAGMLWPDGKSWGEGGGEFDRLAALLKAGLTAVRDCDPGIRTMLHLAEGGDIDMAQWWLDEIVNRDVDFDVVGLSYYPYWDGNFSKLKQVMELVTNDYGKGVNVVETAYGFTTDNGDNLDNIFSNEYAQLVGYPASPQGQASYLRDLMETIHTAGGEGFYYWEPLWIPVSGASWANEAGMRYIQTEGEVGNAWDNQAMFDFNGEALPSLDVFHLVNQSR

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Crispr_ID: NZ_CP012475_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012475_14

4095881-4095976

Orphan

Consensus_repeat	Method
CACGCACTCACTAAGAGTGCGACTGAAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012475_14

>merge|NZ_CP012475|14|4095881-4095976|CRISPRCasFinder
CACGCACTCACTAAGAGTGCGACTGAAGCCATCCAAAAAAAACAAGATGGAATCGTTATTTCAATCCACGCACTCACTAAGAGTGCGACTGAAGCC

>NZ_CP012475|14|14|4095881-4095976|CRISPRCasFinder
CACGCACTCACTAAGAGTGCGACTGAAGCC	ATCCAAAAAAAACAAGATGGAATCGTTATTTCAATC
CACGCACTCACTAAGAGTGCGACTGAAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012475.1\|WP_035201326.1\|4098078_4098279_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035201338.1\|4094082_4094928_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_051881087.1\|4091567_4093007_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NZ_CP012475.1\|WP_051881086.1\|4093429_4093951_-\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NZ_CP012475.1\|WP_156323130.1\|4097895_4098057_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035201329.1\|4097341_4097719_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_169024128.1\|4095020_4095182_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035201339.1\|4093003_4093366_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_169024188.1\|4099150_4099324_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_011246944.1\|4087869_4088280_-\|DUF2188-domain-containing-protein	unknown	unknown	gnl\|CDD\|227213
NZ_CP012475.1\|WP_142300536.1\|4096155_4096386_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197775
NZ_CP012475.1\|WP_035201332.1\|4096712_4097345_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP012475.1\|WP_051881085.1\|4098361_4099132_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035201320.1\|4101197_4101398_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035201342.1\|4091063_4091552_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP012475.1\|WP_051881084.1\|4099344_4100835_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035201322.1\|4100985_4101201_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_156323129.1\|4090010_4091033_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012475.1\|WP_035201336.1\|4095446_4095794_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP012475.1\|WP_035201344.1\|4088780_4089932_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173838

Protein	Function_ID	Function_description	E-value
NZ_CP012475.1\|WP_051881087.1\|4091567_4093007_-\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	8.18211e-52
NZ_CP012475.1\|WP_035201342.1\|4091063_4091552_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.96662e-07
NZ_CP012475.1\|WP_051881086.1\|4093429_4093951_-\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	1.23369e-10
NZ_CP012475.1\|WP_011246944.1\|4087869_4088280_-\|DUF2188-domain-containing-protein	gnl\|CDD\|227213	COG4876, COG4876, Uncharacterized protein conserved in bacteria [Function unknown].	1.06069e-27
NZ_CP012475.1\|WP_035201336.1\|4095446_4095794_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	7.64745e-16
NZ_CP012475.1\|WP_142300536.1\|4096155_4096386_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	1.31804e-11
NZ_CP012475.1\|WP_035201332.1\|4096712_4097345_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	0.00533516
NZ_CP012475.1\|WP_035201344.1\|4088780_4089932_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	2.51618e-54

>NZ_CP012475.1|WP_035201336.1|4095446_4095794_-|helix-turn-helix-domain-containing-protein
MNLGERIRSLREKEELTQKQLAEKLKIPHQNLSNYERNFRQPDYETLNKIASYFDVSVDYLLGRTDNPNSDISIAYDGGIKYEDEDEREFIEQQLEQYRKMKKRMQERLKQDKNN
>NZ_CP012475.1|WP_169024128.1|4095020_4095182_-|hypothetical-protein
MKVIAILLVILGVLGLLMSTLMYGDIGIAAGIGALTALLSGFGFLNLNKKLSN
>NZ_CP012475.1|WP_035201338.1|4094082_4094928_-|hypothetical-protein
MKKVLNILVIFIVLIMAACSNNTTEPTEADTSEIESGNDEKVSSSEMLTENEFYQMLASPKDYIGSQVEFIGKVFSVEKDSEGVYLQVWQDIHNNENNMLVGIYDNSFEVSTDDYIKVKAEIIDEFEGENAFGATLTLPAVEAYEYELIGYADAVSPTEFEVDVAETQEQSGYVVTINKIEFGAEDFRLFVEIENQSDDVINFWKHDAKLVAGNNQFDSDSNWAADYPEVQSELLPGVSTEGIISFPYINYEEVNQVTVHLGGSSDNWDISIDDFVFNIEW
>NZ_CP012475.1|WP_051881086.1|4093429_4093951_-|ImmA/IrrE-family-metallo-endopeptidase
MKYTTQREITISNQMKSLGIYSPSDLTYENLCTVFNIDILYRNGQSKCIFEDDYALIFLDNRLPYYEQRRVFFHELAHYLYHYGNQRKMPKPLLSLQEEQASYISLYLAMPRHIFEPALLKYESVESLQEVFELPKDMIVDRCNSLKRQRHRKVIQTKLQYKQLKHRRKREYK
>NZ_CP012475.1|WP_035201339.1|4093003_4093366_-|hypothetical-protein
MKLGVYYEDRDGELLPMWLLLPVDLRQEYVTYNIMAPFERIDDFHDSLSAVTVTIGALSKGPFDPYDITIHIPTVRKELFLTGYNPEHLNEADYFILQMADVEELLQLEVRRLYVGGNDT
>NZ_CP012475.1|WP_051881087.1|4091567_4093007_-|recombinase-family-protein
MKTAIYLRVSTEEQAKEGFSIRAQRERLDMFARSQDWDVVDFYIDEGRSAKDTERPELQRMLDDIANNRIEVVLVYKLDRLTRSVMDLYQLLEQFEKHGCMFKSATEVFDTTTPTGRLFITLVAAVAQWERENLADRVKFGMEQMVEEGRWPGGPAPFGYILGENSKLKADPDEAELYRYMYDLYENFKGDNAISIILNHELKKKTRLGNQFSAKTVRDILKNPISYGALKWGGKVYEGFCEGIITKERYDRHLALRAARSTVSPKAVTSTYIFTGTIKCARCGAPMKGRMSKSVNNSTYAYLACTNKREKKCDMPMVSEQNVEKHFLNELQLLLASQFDAANEIAASSHNEDRLINQRVQQIQKQIQTIKDRKKKWQMAYADDVISLEELREHTNQDRKRQEELETELADLSSQTESHSPEKVVAILSNFLDNWDQLEPMEKKQAVMLLLERFDVNAEDGKRVLHSKRNLVLSNFKFR
>NZ_CP012475.1|WP_035201342.1|4091063_4091552_-|helix-turn-helix-domain-containing-protein
MIGAVLRGEEEAKKWFNGVMKQKEAASYLGISVYKIRKLREENKIPYSQIFKNIYFHKTILDAWKMNKFPNGRVELVLDDESINFAHEKALKEHYKRYPELAKEKEALNKKNKPLLNNDSKIDYQVKNNGVELVIGSNHAIKTSIFLSNKAIIEMYNDINKN
>NZ_CP012475.1|WP_156323129.1|4090010_4091033_-|hypothetical-protein
MPLVGTLLLPVAIRAGLPPLVGAAAIAIAGQGMALSSDYMIQIAPMLSATAAGVPVSDVADRALVLSLIAGGTAMIVLYLLARRRKERLRASFPKEWMQPYKQRYTAVVSWKAKLFAAFVPLAFLAVILYMLYTSFFTNLQLEGGSGAALVGGAALLLLLVAGLFYRPKQLFEDVSNHLVDGFLFAFKAMGPVIPIAGFFFLGSSDFAPAILAIDEAPAFLFELVKAGESYIPTEPGWTAFGLLMIGMITGLDGSGFSGLPLTGALAGALAPVSGIDPATLAAIGQMGAVWVGGGTLIAWSSLVAVAGIARVHVQDLVRICFIPVIAGLLVSTILALVIW
>NZ_CP012475.1|WP_035201344.1|4088780_4089932_+|acyl-CoA-dehydrogenase-family-protein
MSILDEQSAVGREQALRHILTGFSEIGAIHDHQQTVPIENIAALKKSGYTALPVETKYGGRQISLSEMLYLQQLIAEEDGPTALCIGWHMGTMYQLVEEKNWPKHWHEQISCDVVEKGVLLNTAATEKATGSPTRGGAFQTTAKYERGEWVLNGTKTFTTLAEHLDYYLILATVEPEKQVGLFIVPQNTPGVTVEKTWDMMAMGSTGSEDLHLKNVKLPSDHFIKKQEKNGLPTAWLLHIPACYLGIACAAIREAAKFANSYSPNSIQGTIAQLPHVKQKLGEAVILYEQSRHFLYSVANKWDNSDKETRMQLNTELKMVKYAVVNNANRIVDTVMRAVGAHSLSNQSPLSRYYKNVRAGLHNPPMDDMVVHAAAESVLQRES
>NZ_CP012475.1|WP_011246944.1|4087869_4088280_-|DUF2188-domain-containing-protein
MPWTMDDYPSSLKNFDKAIRKKAIEMANSMVKDGYSESRAIPIATEQAKKWKENADDNEIAHFLKHGKVTPSKHDSSSSSPETADKPEHVVKREDGWAVYAEGAKRASYVANTKEEALQRARKIAKNKGAGVKVDD
>NZ_CP012475.1|WP_142300536.1|4096155_4096386_+|helix-turn-helix-domain-containing-protein
MRQIKVNQNLRVIRKSKGMTQKYVAISLGMPVQTYNSYELGRRKISADLLKEIAIVLDEPIENFFENKLYETKNIG
>NZ_CP012475.1|WP_035201332.1|4096712_4097345_+|helix-turn-helix-domain-containing-protein
MANTLSQTRLYHASQIGDVLRIARERASKPEHRTKQRMAEELGITVARLTRIEEGTAQVPLELAIQWCQIVNDHTALAKVRHIWGLDLPATNPLLQEDMLSQLINFRRQATQAIEAIAGLLDISVQLRPGDNVTERFGKELYEHAEEILDMKQATESLLTSLSLNWGLDREKLRRSWTQEALADGVLVTSVSHYEEIKKEQFFSERAASL
>NZ_CP012475.1|WP_035201329.1|4097341_4097719_+|hypothetical-protein
MKTKALNGMNSAEIQVIKETLERQCRVKSKEQIFFPMVLEKVKQHGSNVELDGMEMKLICFALRRKALILTAVYGMDAQQQQKKVLYNLAFEISKRRIQFQQSNNPVNKKEAQTAATVHASALNL
>NZ_CP012475.1|WP_156323130.1|4097895_4098057_+|hypothetical-protein
MSLTQGLLQTAAQLEEVKRSLKEVQISLAEDSSQGNVEEQIAVLSSIIDDLNY
>NZ_CP012475.1|WP_035201326.1|4098078_4098279_+|hypothetical-protein
MLRYWSSEGCYKWLNEDQQFYLYHHIAVLGFSVVHRVARRLGMTSDEAIQVFNELHKRKKPNQLAG
>NZ_CP012475.1|WP_051881085.1|4098361_4099132_+|hypothetical-protein
MDNQLQPIESAANIARVQVTPAQALEAYNALKDITKKVLVPGTDYGKIPGTPKPTLLKSGAENLLRFYGLGHRLQVIEQVKDWENGFFYFSYKVTVHRTSETGVEFVLSECEGSANSKEKRYRNQDAYMLVNTLQKMAIKRALVGATLQATGASGLFTQDIEDMDSSYNSNSPSSNQPKSNGSNGAATEAQIKAINSGAKRKGLTEEEINQLSSNIHKVDTLKSLTKQQASDMITLFNSSTEEELKGMLGSASEHS
>NZ_CP012475.1|WP_169024188.1|4099150_4099324_+|hypothetical-protein
MEYRIPIPHIYKSIALASSDPAGTYYKYAESYIRSNYPELILIRHEKGVAVCILKEN
>NZ_CP012475.1|WP_051881084.1|4099344_4100835_+|hypothetical-protein
MQGYIKDYRKELDSDIWMMSPLYHRVWTYLKYKANYKEGKIPLKDGTFITILPGQHLTSTRKIASGVAYYEKKQLIVPTAKTIRDILKWMVKRQMITTEHGRKGNEYTLITILNWSNYQSEEPVVENERGVTGNTKETAKSQSSQGIQDIEAVTSNSNDEKGTKHLTDCKTPVRGNTVETPESLTDQGIRNGNHVIGNTSETARKHLLPINKKEKNNKELLNTNTTNDVQELASFDDDFGLLYGQEPDEKDLLVAHFNQQVGRLTPVGADYCVAADLLDTMQLDHAKQLVDVSIKKIKERKGSQVKINSLGYLAPVMKELYDVYLAREAARRDNVVQLTPRSQAINEDSEAYDLAKLLLNEIRKVQPDFSQPDMNVWAASFANMIAAGKEPKRIQAALLYARSEPFWMTRVLNPEKLAKYYDTLQQQIATSKQANRQPRNNQRRAPEPSWLTEDRQTGTKNSQDSAMQETKAKIARLMAERKKQRAESEAAYGGGY
>NZ_CP012475.1|WP_035201322.1|4100985_4101201_+|hypothetical-protein
MIQEVMHTHCKRCSRPLRGKESMLRGYGPVCAQKVKYGQQLDLVDMLDKPQSSQVDEQNFMDELEERRKVV
>NZ_CP012475.1|WP_035201320.1|4101197_4101398_+|hypothetical-protein
MKITTDKNGVSHCELSNGEVGIMYRLPRAVVVRFEGREELLPNEQAALAWMHAKERECRKEKVQNA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP012475_1	1.1\|415904\|37\|NZ_CP012475\|CRISPRCasFinder	415904-415940	37	NZ_CP012475.1	363237-363273	1	0.973
NZ_CP012475_1	1.1\|415904\|37\|NZ_CP012475\|CRISPRCasFinder	415904-415940	37	NZ_CP012475.1	506102-506138	1	0.973
NZ_CP012475_1	1.1\|415904\|37\|NZ_CP012475\|CRISPRCasFinder	415904-415940	37	NZ_CP012475.1	3055827-3055863	1	0.973

1. spacer 1.1|415904|37|NZ_CP012475|CRISPRCasFinder matches to position: 363237-363273, mismatch: 1, identity: 0.973

cagtctgatggcggttatcgactttgtcgacaacctc	CRISPR spacer
cagtctgagggcggttatcgactttgtcgacaacctc	Protospacer
******** ****************************

2. spacer 1.1|415904|37|NZ_CP012475|CRISPRCasFinder matches to position: 506102-506138, mismatch: 1, identity: 0.973

cagtctgatggcggttatcgactttgtcgacaacctc	CRISPR spacer
cagtctgagggcggttatcgactttgtcgacaacctc	Protospacer
******** ****************************

3. spacer 1.1|415904|37|NZ_CP012475|CRISPRCasFinder matches to position: 3055827-3055863, mismatch: 1, identity: 0.973

cagtctgatggcggttatcgactttgtcgacaacctc	CRISPR spacer
cagtctgagggcggttatcgactttgtcgacaacctc	Protospacer
******** ****************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012475_10	10.3\|2610498\|34\|NZ_CP012475\|PILER-CR,CRISPRCasFinder,CRT	2610498-2610531	34	NZ_MF503688	Bacillus xiamenensis strain HYC-10 plasmid pHYC-10, complete sequence	2038-2071	8	0.765
NZ_CP012475_10	10.3\|2610498\|34\|NZ_CP012475\|PILER-CR,CRISPRCasFinder,CRT	2610498-2610531	34	NC_001764	Bacillus subtilis plasmid pTA1040, complete sequence	5590-5623	8	0.765
NZ_CP012475_3	3.1\|2514398\|31\|NZ_CP012475\|PILER-CR	2514398-2514428	31	NC_017543	Paenibacillus polymyxa M1 plasmid pPPM1a, complete sequence	72539-72569	9	0.71
NZ_CP012475_10	10.2\|2610432\|34\|NZ_CP012475\|PILER-CR,CRISPRCasFinder,CRT	2610432-2610465	34	NC_019700	Oscillatoria acuminata PCC 6304 plasmid pOSCIL6304.01, complete sequence	26308-26341	9	0.735
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	NZ_CP044475	Acinetobacter schindleri strain HZE33-1 plasmid pHZE33-1-1, complete sequence	97947-97978	10	0.688
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	NZ_CP044446	Acinetobacter indicus strain CMG3-2 plasmid pCMG3-2-1, complete sequence	6939-6970	10	0.688
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	NZ_CP044484	Acinetobacter schindleri strain HZE30-1 plasmid pHZE30-1-1, complete sequence	76444-76475	10	0.688
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	NZ_MN366357	Bacterium plasmid pALTS28, complete sequence	46616-46647	10	0.688
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	NZ_CP044451	Acinetobacter indicus strain MMS9-2 plasmid pMMS9-2-1, complete sequence	41336-41367	10	0.688
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	NZ_CP047350	Proteus cibarius strain ZN2 plasmid pZN2-tetX-171kb, complete sequence	54504-54535	10	0.688
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	NZ_CP047345	Proteus vulgaris strain ZN3 plasmid pZN3-tetX-171kb, complete sequence	54502-54533	10	0.688
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	NZ_CP047353	Proteus mirabilis strain ZA25 plasmid pZA25-tetX-168kb, complete sequence	51808-51839	10	0.688
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	NZ_CP048015	Acinetobacter towneri strain 205 plasmid pAT205, complete sequence	47338-47369	10	0.688
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	CP046596	Acinetobacter indicus strain FS42-2 plasmid pFS42-2-1, complete sequence	128234-128265	10	0.688
NZ_CP012475_9	9.3\|2606192\|32\|NZ_CP012475\|PILER-CR,CRT	2606192-2606223	32	NZ_CP044464	Acinetobacter schindleri strain HZE23-1 plasmid pHZE23-1-1, complete sequence	44439-44470	10	0.688
NZ_CP012475_3	3.3\|2514396\|34\|NZ_CP012475\|CRISPRCasFinder	2514396-2514429	34	NC_017543	Paenibacillus polymyxa M1 plasmid pPPM1a, complete sequence	72538-72571	11	0.676
NZ_CP012475_6	6.13\|2579826\|33\|NZ_CP012475\|PILER-CR,CRISPRCasFinder,CRT	2579826-2579858	33	AY249139	Lactococcus phage bIL66M1 E15 (e15) gene, partial cds; and E14 (e14), E13 (e13), E12 (e12), E11 (e11), E10 (e10), E9 (e9), E8 (e8), E7 (e7), E6 (e6), E5 (e5), E4 (e4), E3 (e3), E2 (e2), and E1 (e1) genes, complete cds	6033-6058	11	0.667
NZ_CP012475_11	11.3\|2614847\|34\|NZ_CP012475\|CRISPRCasFinder	2614847-2614880	34	NZ_CP013925	Acinetobacter baumannii strain KBN10P02143 plasmid pKBN10P02143, complete sequence	513-546	11	0.676

1. spacer 10.3|2610498|34|NZ_CP012475|PILER-CR,CRISPRCasFinder,CRT matches to NZ_MF503688 (Bacillus xiamenensis strain HYC-10 plasmid pHYC-10, complete sequence) position: , mismatch: 8, identity: 0.765

tgtctctgacattactacccccctgttagctagg	CRISPR spacer
ttcatcttacattactacccccctgttagagtga	Protospacer
* . *** *********************   *.

2. spacer 10.3|2610498|34|NZ_CP012475|PILER-CR,CRISPRCasFinder,CRT matches to NC_001764 (Bacillus subtilis plasmid pTA1040, complete sequence) position: , mismatch: 8, identity: 0.765

tgtctctgacattactacccccctgttagctagg	CRISPR spacer
ttcatcttacattactacccccctgttagagtga	Protospacer
* . *** *********************   *.

3. spacer 3.1|2514398|31|NZ_CP012475|PILER-CR matches to NC_017543 (Paenibacillus polymyxa M1 plasmid pPPM1a, complete sequence) position: , mismatch: 9, identity: 0.71

tttgaaattggaaatccaataagttcattct	CRISPR spacer
gcccgaattggaaatccaatatgttgatttc	Protospacer
 .. .**************** *** ***..

4. spacer 10.2|2610432|34|NZ_CP012475|PILER-CR,CRISPRCasFinder,CRT matches to NC_019700 (Oscillatoria acuminata PCC 6304 plasmid pOSCIL6304.01, complete sequence) position: , mismatch: 9, identity: 0.735

aactagcaaggaaaaatgcaaaatctcaattact	CRISPR spacer
accccccaaggaaaaatgaaaaatttcaatttta	Protospacer
* *.  ************ *****.****** .

5. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to NZ_CP044475 (Acinetobacter schindleri strain HZE33-1 plasmid pHZE33-1-1, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

6. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to NZ_CP044446 (Acinetobacter indicus strain CMG3-2 plasmid pCMG3-2-1, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

7. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to NZ_CP044484 (Acinetobacter schindleri strain HZE30-1 plasmid pHZE30-1-1, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

8. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to NZ_MN366357 (Bacterium plasmid pALTS28, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

9. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to NZ_CP044451 (Acinetobacter indicus strain MMS9-2 plasmid pMMS9-2-1, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

10. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to NZ_CP047350 (Proteus cibarius strain ZN2 plasmid pZN2-tetX-171kb, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

11. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to NZ_CP047345 (Proteus vulgaris strain ZN3 plasmid pZN3-tetX-171kb, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

12. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to NZ_CP047353 (Proteus mirabilis strain ZA25 plasmid pZA25-tetX-168kb, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

13. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to NZ_CP048015 (Acinetobacter towneri strain 205 plasmid pAT205, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

14. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to CP046596 (Acinetobacter indicus strain FS42-2 plasmid pFS42-2-1, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

15. spacer 9.3|2606192|32|NZ_CP012475|PILER-CR,CRT matches to NZ_CP044464 (Acinetobacter schindleri strain HZE23-1 plasmid pHZE23-1-1, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacagttgttacatcaaaacggtgtggagc	CRISPR spacer
ggcgagattgttacagcaaaacggcgtggaca	Protospacer
 * . ..******** ********.*****

16. spacer 3.3|2514396|34|NZ_CP012475|CRISPRCasFinder matches to NC_017543 (Paenibacillus polymyxa M1 plasmid pPPM1a, complete sequence) position: , mismatch: 11, identity: 0.676

attttgaaattggaaatccaataagttcattctt	CRISPR spacer
ctgcccgaattggaaatccaatatgttgatttcg	Protospacer
 * .. .**************** *** ***..

17. spacer 6.13|2579826|33|NZ_CP012475|PILER-CR,CRISPRCasFinder,CRT matches to AY249139 (Lactococcus phage bIL66M1 E15 (e15) gene, partial cds; and E14 (e14), E13 (e13), E12 (e12), E11 (e11), E10 (e10), E9 (e9), E8 (e8), E7 (e7), E6 (e6), E5 (e5), E4 (e4), E3 (e3), E2 (e2), and E1 (e1) genes, complete cds) position: , mismatch: 11, identity: 0.667

atcagggtaagtagctgttcttttttcattttt	CRISPR spacer
-------taagtagctgttcttctgtcatttgc	Protospacer
       ***************.* ****** .

18. spacer 11.3|2614847|34|NZ_CP012475|CRISPRCasFinder matches to NZ_CP013925 (Acinetobacter baumannii strain KBN10P02143 plasmid pKBN10P02143, complete sequence) position: , mismatch: 11, identity: 0.676

aacgatttcctcttgattgattttaataatcatt	CRISPR spacer
ttaaacacactcttttttgattttaataatcata	Protospacer
   .*. . *****  *****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

911557 : 919762

Cyanophage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_035204825.1\|911557_912142_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	4.2e-25	36.4
WP_011245886.1\|913198_914611_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.4e-50	34.2
WP_035204817.1\|914586_916812_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	3.3e-163	43.5
WP_011245884.1\|916795_917479_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_011245883.1\|917475_917727_-	phosphoribosylformylglycinamidine synthase subunit PurS	A0A1D7SRI3	Cyanophage	2.1e-05	34.6
WP_035204815.1\|917719_918439_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SPE1	Cyanophage	1.7e-47	43.7
WP_035204813.1\|918463_919762_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	5.5e-17	32.1

DBSCAN-SWA_2

3117030 : 3125776

Bacillus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011247957.1\|3117030_3118521_+	sucrose-6-phosphate hydrolase	F8WPR5	Bacillus_phage	9.8e-34	28.5
WP_011247956.1\|3118645_3119401_-	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	7.4e-14	28.8
WP_011247955.1\|3119527_3120820_-	glycoside hydrolase family 18 protein	NA	NA	NA	NA
WP_011247954.1\|3120899_3121106_-	hypothetical protein	NA	NA	NA	NA
WP_011247953.1\|3121226_3121772_+	cysteine hydrolase	G3MA16	Bacillus_virus	5.3e-30	41.1
WP_011247952.1\|3121818_3122445_-	hypothetical protein	A0A127AYS1	Bacillus_phage	1.1e-44	42.0
WP_011247951.1\|3122632_3123637_-	class 1b ribonucleoside-diphosphate reductase subunit beta	R4JMU8	Bacillus_phage	7.3e-150	80.1
WP_035202795.1\|3123673_3125776_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	U5PY35	Bacillus_phage	0.0e+00	79.6

DBSCAN-SWA_3

4098361 : 4105961

Paenibacillus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_051881085.1\|4098361_4099132_+	hypothetical protein	A6M982	Geobacillus_virus	3.3e-25	39.2
WP_169024188.1\|4099150_4099324_+	hypothetical protein	NA	NA	NA	NA
WP_051881084.1\|4099344_4100835_+	hypothetical protein	A0A0C5AFF7	Paenibacillus_phage	1.2e-34	52.9
WP_035201322.1\|4100985_4101201_+	hypothetical protein	NA	NA	NA	NA
WP_035201320.1\|4101197_4101398_+	hypothetical protein	NA	NA	NA	NA
WP_035201318.1\|4101390_4101822_+	single-stranded DNA-binding protein	A0A290GHL8	Caldibacillus_phage	4.0e-49	68.3
WP_035201316.1\|4101944_4102142_+	hypothetical protein	NA	NA	NA	NA
WP_035201314.1\|4102138_4102675_+	Holliday junction resolvase RecU	A0A0K2CP48	Brevibacillus_phage	4.4e-37	49.7
WP_035201312.1\|4102738_4103548_+	DNA adenine methylase	Q8W5X3	Listeria_phage	1.1e-63	48.2
WP_051881083.1\|4103608_4104394_+	hypothetical protein	R9VWW9	Paenibacillus_phage	2.6e-30	51.1
WP_035201311.1\|4104414_4104615_+	XtrA/YqaO family protein	A0A1L2JY31	Aeribacillus_phage	1.3e-10	53.0
WP_035201309.1\|4104611_4105127_+	hypothetical protein	NA	NA	NA	NA
WP_035201307.1\|4105225_4105420_+	hypothetical protein	NA	NA	NA	NA
WP_035201304.1\|4105436_4105961_+	sigma-70 family RNA polymerase sigma factor	A0A1L2JY33	Aeribacillus_phage	6.1e-23	38.5

DBSCAN-SWA_4

4109849 : 4166014

Bacillus_phage(45.83%)

tail,protease,terminase,portal,head,capsid,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_035201295.1\|4109849_4110689_+\|terminase	terminase small subunit	A0A0A7RTY1	Clostridium_phage	3.9e-72	56.4
WP_035201291.1\|4110678_4111875_+\|terminase	PBSX family phage terminase large subunit	A0A2H4J8B0	uncultured_Caudovirales_phage	8.3e-185	74.8
WP_035201276.1\|4111883_4113266_+\|portal	phage portal protein	A0A2H4J4Q7	uncultured_Caudovirales_phage	9.1e-135	54.8
WP_035201273.1\|4113243_4114155_+\|head	phage head morphogenesis protein	A0A1Q1PVS5	Bacillus_phage	1.1e-56	40.5
WP_035201270.1\|4114151_4114361_+	hypothetical protein	NA	NA	NA	NA
WP_051881081.1\|4114443_4115055_+	DUF4355 domain-containing protein	A0A2H4J4P4	uncultured_Caudovirales_phage	5.7e-49	55.2
WP_035201266.1\|4115072_4115441_+	hypothetical protein	A0A0K2CNR0	Brevibacillus_phage	5.3e-34	62.3
WP_035201263.1\|4115459_4116506_+\|capsid	major capsid protein	S5MNB6	Brevibacillus_phage	3.0e-138	68.4
WP_156323132.1\|4116544_4116685_+	hypothetical protein	NA	NA	NA	NA
WP_035201260.1\|4116681_4116993_+\|head,tail	phage head-tail connector protein	Q4ZCE6	Staphylococcus_virus	4.3e-08	35.0
WP_035201257.1\|4116982_4117324_+	hypothetical protein	NA	NA	NA	NA
WP_094978930.1\|4117334_4117724_+	HK97 gp10 family phage protein	O48447	Bacillus_phage	2.5e-26	53.0
WP_035201251.1\|4117720_4118131_+	DUF3168 domain-containing protein	A0A0K1LLG5	Bacillus_phage	2.5e-08	30.5
WP_051881080.1\|4118136_4118688_+\|tail	phage major tail protein, TP901-1 family	NA	NA	NA	NA
WP_051881079.1\|4118761_4119226_+	hypothetical protein	O48453	Bacillus_phage	3.3e-12	33.9
WP_051881078.1\|4119345_4119582_+	hypothetical protein	NA	NA	NA	NA
WP_151210677.1\|4119809_4122722_+	hypothetical protein	H9A0P1	Staphylococcus_phage	1.0e-47	28.7
WP_035201248.1\|4122734_4123652_+\|tail	phage tail family protein	NA	NA	NA	NA
WP_035201246.1\|4123664_4125716_+\|tail	phage tail protein	U3PDY0	Staphylococcus_phage	4.2e-43	28.0
WP_156323133.1\|4125728_4125869_+	hypothetical protein	NA	NA	NA	NA
WP_156323134.1\|4125837_4125990_+	hypothetical protein	NA	NA	NA	NA
WP_035201243.1\|4126005_4128459_+\|tail	tail fiber domain-containing protein	Q9FZW3	Bacillus_phage	8.3e-131	36.2
WP_035201240.1\|4128716_4129820_+	DUF4263 domain-containing protein	NA	NA	NA	NA
WP_035201238.1\|4130019_4130274_+	hemolysin XhlA family protein	A0A0S2SXU0	Bacillus_phage	1.8e-09	43.9
WP_035201236.1\|4130323_4130593_+\|holin	holin	A0A0U4JE55	Bacillus_phage	4.6e-19	58.8
WP_151210678.1\|4130592_4131531_+	N-acetylmuramoyl-L-alanine amidase	A0A0N6W8I1	Bacillus_phage	1.2e-53	59.8
WP_035201235.1\|4131623_4131968_-	hypothetical protein	NA	NA	NA	NA
WP_035201233.1\|4131964_4133497_-	LXG domain-containing protein	NA	NA	NA	NA
WP_035201231.1\|4133844_4134936_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_035201229.1\|4135191_4135464_+\|holin	holin	A0A0U4JE55	Bacillus_phage	3.0e-18	56.5
WP_051881076.1\|4135460_4136315_+	N-acetylmuramoyl-L-alanine amidase	A0A0S2SXM5	Bacillus_phage	9.8e-39	40.2
WP_082369292.1\|4136269_4136548_+	peptidoglycan-binding protein	NA	NA	NA	NA
WP_035201228.1\|4136732_4136921_+	hypothetical protein	NA	NA	NA	NA
WP_035201227.1\|4136904_4137873_-	hypothetical protein	A0A1S5SA20	Streptococcus_phage	9.5e-14	24.9
WP_051881075.1\|4138147_4138591_+	DUF4065 domain-containing protein	NA	NA	NA	NA
WP_035201225.1\|4138580_4139717_+	hypothetical protein	NA	NA	NA	NA
WP_035201224.1\|4139784_4140072_+	hypothetical protein	NA	NA	NA	NA
WP_051881074.1\|4140173_4140995_+	MBL fold metallo-hydrolase	Q0H255	Geobacillus_phage	3.5e-33	32.4
WP_035201221.1\|4141001_4141262_+	DUF3006 domain-containing protein	NA	NA	NA	NA
WP_035201217.1\|4141479_4142031_-	SMI1/KNR4 family protein	O64022	Bacillus_phage	3.8e-36	44.3
WP_035201214.1\|4142049_4143072_-	HNH endonuclease	NA	NA	NA	NA
WP_011246940.1\|4144392_4145034_-	hypothetical protein	NA	NA	NA	NA
WP_081427713.1\|4145166_4145274_+	hypothetical protein	NA	NA	NA	NA
WP_011246939.1\|4145314_4145563_-	hypothetical protein	NA	NA	NA	NA
WP_142299195.1\|4145699_4146029_-	hypothetical protein	NA	NA	NA	NA
WP_011246938.1\|4146338_4146659_+	PadR family transcriptional regulator	NA	NA	NA	NA
WP_011246937.1\|4146674_4147418_+	DUF1129 domain-containing protein	NA	NA	NA	NA
WP_011246936.1\|4148167_4148833_-	hypothetical protein	NA	NA	NA	NA
WP_011246935.1\|4149137_4149479_+	hypothetical protein	NA	NA	NA	NA
WP_011246934.1\|4149786_4151316_-	glycosyltransferase	NA	NA	NA	NA
WP_035201670.1\|4151818_4152331_+	DinB family protein	NA	NA	NA	NA
WP_035201206.1\|4152497_4152863_-	hypothetical protein	NA	NA	NA	NA
WP_011246931.1\|4152955_4153696_-	HAD family phosphatase	NA	NA	NA	NA
WP_011246930.1\|4154009_4155560_+	PTS transporter subunit EIIC	A0A2I7SAJ6	Vibrio_phage	4.7e-07	35.7
WP_011246929.1\|4155580_4156954_+	adenylosuccinate lyase family protein	A0A2H4UUU6	Bodo_saltans_virus	3.4e-09	27.0
WP_011246928.1\|4157031_4157769_-	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_011246927.1\|4158007_4158145_-	hypothetical protein	NA	NA	NA	NA
WP_035201204.1\|4158439_4158868_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_011246925.1\|4158851_4159082_+	DUF3147 family protein	NA	NA	NA	NA
WP_073304124.1\|4159223_4159406_+	DUF4177 domain-containing protein	NA	NA	NA	NA
WP_035201202.1\|4159605_4159821_+	hypothetical protein	NA	NA	NA	NA
WP_011246924.1\|4159932_4160187_-	hypothetical protein	NA	NA	NA	NA
WP_011246923.1\|4160620_4162018_-	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_011246922.1\|4162047_4162794_-	chitin disaccharide deacetylase	NA	NA	NA	NA
WP_011246921.1\|4162842_4164168_-	6-phospho-alpha-glucosidase	NA	NA	NA	NA
WP_142299357.1\|4164482_4165190_+	UTRA domain-containing protein	NA	NA	NA	NA
WP_011246919.1\|4165375_4166014_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP012476

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP012475

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection