CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022604	Staphylococcus aureus subsp. aureus Z172, complete sequence	10 crisprs	cas3,DEDDh,DinG,csa3,WYL	10	2	12	1
NC_022605	Staphylococcus aureus subsp. aureus Z172 plasmid pZ172_2, complete sequence	0 crisprs	NA	0	0	0	0
NC_022610	Staphylococcus aureus subsp. aureus Z172 plasmid pZ172_1, complete sequence	0 crisprs	csa3	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022604_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022604_1

430037-430137

Orphan

Consensus_repeat	Method
TTATGAATTGAGTATTAAATTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022604_1

>merge|NC_022604|1|430037-430137|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTGAAAGTAAATTACAGTTCTATAGGTTTATAAAAATCAGTTTTTAAATCAAAGCTATATATGAATTGAGTATTAAATTTG

>NC_022604|1|1|430037-430137|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTG	AAAGTAAATTACAGTTCTATAGGTTTATAAAAATCAGTTTTTAAATCAAAGCTAT
ATATGAATTGAGTATTAAATTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022604.1\|WP_001289311.1\|426952_427708_+\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|380322
NC_022604.1\|WP_000763768.1\|432032_432440_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378584
NC_022604.1\|WP_000052781.1\|425891_426461_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|211789
NC_022604.1\|WP_000237797.1\|437936_439130_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_022604.1\|WP_000991007.1\|427788_429177_-\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
NC_022604.1\|WP_000868248.1\|422643_423027_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000158374.1\|421996_422578_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NC_022604.1\|WP_000633907.1\|439156_439357_-\|DUF3173-family-protein	unknown	unknown	gnl\|CDD\|371495
NC_022604.1\|WP_000211676.1\|421609_421819_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000421410.1\|432952_433531_+\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
NC_022604.1\|WP_001789518.1\|429261_429363_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000394699.1\|431227_431890_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000793010.1\|433530_434799_+\|purine-permease	unknown	unknown	gnl\|CDD\|274468
NC_022604.1\|WP_001795623.1\|423980_424274_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000956132.1\|430153_431110_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235334
NC_022604.1\|WP_000424966.1\|436327_437869_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NC_022604.1\|WP_000845143.1\|439854_440085_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378900
NC_022604.1\|WP_000930486.1\|424352_425876_-\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942
NC_022604.1\|WP_000264071.1\|434836_436303_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NC_022604.1\|WP_000746687.1\|423281_423908_-\|NDxxF-motif-lipoprotein	unknown	unknown	gnl\|CDD\|380196

Protein	Function_ID	Function_description	E-value
NC_022604.1\|WP_001289311.1\|426952_427708_+\|NADPH-dependent-oxidoreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	5.03864e-88
NC_022604.1\|WP_000763768.1\|432032_432440_-\|hypothetical-protein	gnl\|CDD\|378584	pfam11181, YflT, Heat induced stress protein YflT. YflT is a heat induced protein.	2.0219e-12
NC_022604.1\|WP_000052781.1\|425891_426461_-\|peroxiredoxin	gnl\|CDD\|211789	TIGR03137, AhpC, peroxiredoxin. This peroxiredoxin (AhpC, alkylhydroperoxide reductase subunit C) is one subunit of a two-subunit complex with subunit F(TIGR03140). Usually these are found as an apparent operon. The gene has been characterized in Bacteroides fragilis, where it is important in oxidative stress defense. This gene contains two invariant cysteine residues, one near the N-terminus and one near the C-terminus, each followed immediately by a proline residue. [Cellular processes, Detoxification, Cellular processes, Adaptations to atypical conditions].	1.50623e-124
NC_022604.1\|WP_000237797.1\|437936_439130_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.36769e-47
NC_022604.1\|WP_000991007.1\|427788_429177_-\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
NC_022604.1\|WP_000158374.1\|421996_422578_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	2.78414e-49
NC_022604.1\|WP_000633907.1\|439156_439357_-\|DUF3173-family-protein	gnl\|CDD\|371495	pfam11372, DUF3173, Domain of unknown function (DUF3173). This family of proteins with unknown function appears to be restricted to Firmicutes. These proteins appear to be distantly related to HHH domains and are therefore likely to be DNA-binding. Genomic environment-visualisation confirms the likely function as being DNA-binding, as this short protein lies very closely between an integrase and a replication protein (http://www.microbesonline.org/).	2.02242e-22
NC_022604.1\|WP_000793010.1\|433530_434799_+\|purine-permease	gnl\|CDD\|274468	TIGR03173, pbuX, xanthine permease. All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.	3.16192e-170
NC_022604.1\|WP_000421410.1\|432952_433531_+\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	9.01486e-119
NC_022604.1\|WP_000264071.1\|434836_436303_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NC_022604.1\|WP_000956132.1\|430153_431110_-\|hypothetical-protein	gnl\|CDD\|235334	PRK05035, PRK05035, electron transport complex protein RnfC; Provisional.	0.000748442
NC_022604.1\|WP_000424966.1\|436327_437869_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NC_022604.1\|WP_000845143.1\|439854_440085_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378900	pfam12645, HTH_16, Helix-turn-helix domain. This domain appears to be a helix-turn-helix domain suggesting that this might be a transcriptional regulatory protein. Some members of this family are annotated as conjugative transposon domains.	2.04673e-25
NC_022604.1\|WP_000930486.1\|424352_425876_-\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0
NC_022604.1\|WP_000746687.1\|423281_423908_-\|NDxxF-motif-lipoprotein	gnl\|CDD\|380196	NF033193, lipo_NDxxF, NDxxF motif lipoprotein. Members of this family are lipoproteins, about 200 amino acids long in precursor form, found in Staphylococcus aureus, Bacillus cereus, and various other Firmicutes. The protein family is named for one of its several highly conserved motifs.	1.67126e-71

>NC_022604.1|WP_001789518.1|429261_429363_+|hypothetical-protein
MQLNVNMMKFDRWHKGICKQIVLNSVVIGGKGK
>NC_022604.1|WP_000991007.1|427788_429177_-|L-cystine-transporter
MNAFLTLINIIVLVIFIVILHMMARKHISFAKRVFTALGIGIVFGVLLHLIYGTHSNVITSTSDWFNIVGQGYVALLQMIVMPLIFISIVAAFTKIQIGEKFAKIGSLIFIFLIGTVTIAAIVGVVYALVFGLDASTINLGNAEQARGSEIAKQAKDLTAHTLPQQILELLPKNPFLDFTGQRATSTIAVVIFASFIGFAYLRVARKQPDHGELLKRAIDAIYSLVMAIVTFVLRLTPYGVLAIMANTLSTSDFGAIWTLGKFLIASYAALITMYIIHLIILSLLGISPIRYVKKTLEVLIFAFTSRSSAGALPLNVQTQTRRLGVPEGIANFAATFGLSIGQNGCAGIYPAMLAIMVAPVANVEIDLQFIVTLIAVVIISSFGVAGVGGGATFASILVLSTLNLPVALAGVLISVEPLIDMGRTALNVNDSMLAGTGTAKLTKHWDKDTFDSNDNAALTSH
>NC_022604.1|WP_001289311.1|426952_427708_+|NADPH-dependent-oxidoreductase
MSEHVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKENLREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAENIAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPFDHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDMLEQLQKSGLIQR
>NC_022604.1|WP_000052781.1|425891_426461_-|peroxiredoxin
MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLAQRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQPGLDLVGKI
>NC_022604.1|WP_000930486.1|424352_425876_-|alkyl-hydroperoxide-reductase-subunit-F
MLNADLKQQLKQLLELMEGNVEFVASLGSDDKSKELKDLLTEITDMSPRLSLSEKSLKRTPSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKKLEGSFHFETFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNGRMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGGQVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENGAVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEAAIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYEDMNTGEEHLLNLDGIFVQIGLLPNTSWLNDAVELNERGEIVIDRNNNTNVPGIFAAGDVTDQKNKQIIISMGAGANAALNAFDYIIRN
>NC_022604.1|WP_001795623.1|423980_424274_-|hypothetical-protein
MINLIYTTRCAIMLKVCTSRKQINMKNDIEKEKYVNEIIMLLRTIPTSKLVQPIMQLFIDKAILNNVQNDALLIEKATHARNHLRLWSLQGHRDIPN
>NC_022604.1|WP_000746687.1|423281_423908_-|NDxxF-motif-lipoprotein
MKKRLLLSTFLASTLILTGCASDQSDNEDHHTSTGIHAPKSAKKLETKDIFNSDKKNSDISDAEMKQAIEKYLSVNSDILDNKYIMQHKLDKQIDSQTKVTEKQAETLSHLSNLAVKNDLHFKKFVTENNIPKEYKKPVELMMNYFKALNSTIANVDEDIEKLSYQPQNKINVVDVPTKYAGDVNKKQQDKIKDFLKSKGIKSDVIDK
>NC_022604.1|WP_000868248.1|422643_423027_-|hypothetical-protein
MKVRITFIILAILSTIVCLFLAAMHPTGPNTVTFEQPYLFTLNIIIMVLVALPSLVLAIYDYMSFRISSAILQFLGAISWFFLSLILSLTQFTPFTLASFITSIILFTSTIITLAIGGKSVEKNDSP
>NC_022604.1|WP_000158374.1|421996_422578_+|histidine-phosphatase-family-protein
MTIYLVRHGESKSNYDNKHFRSYFCGQLDVPLTDTGTKSADDLCDYFKEKQIKHVYVSDLLRTQQTFEHIFPYDIASTTTPLLRERSLGVFEGEYKDEISANPKYEKYFNDPNFKDFRHSFSQKAPEGESYEDVYQRVEHFMNHVVNEDTQKDDIVIVAHQVVIRCLMVYFNKVSRAEAVDLKVENCKPYIIE
>NC_022604.1|WP_000211676.1|421609_421819_-|hypothetical-protein
MTTQSFIFMNIILLDGATQRHPFFICQILAFLFPKFPHINLLLFNPILSTFSNIIIHIDHFHANKKDDN
>NC_022604.1|WP_000956132.1|430153_431110_-|hypothetical-protein
MLTKEFAQRVELSEKQVRKIVQHLEERGYQLSKTEYRGREATDFKEEDIELFKDIADKVKQTNSYDLAFDELEKEKDFLQVIVKNDDKNLPTNQNVAQLVEDLRLEIQKMREERHLLGQMMNQVHQQQQELKELQNQLTSKIDSNSESLKAIQTSQEAIQEAQASQAKALAESTNKVEKNAVTEDKADSKDSKVAGVNTSTDAKTDTKAENAGDGTATKVDKEDQISATEAIEKASVEQSKNDNAAETSNKEATVDAEAQHDAEQQVAEAHAEASKQATSNDSLEAKAENDSTASQSEMSEPKPQEEKKGFFARLFNL
>NC_022604.1|WP_000394699.1|431227_431890_-|hypothetical-protein
MEFKTIQSVKDPHYNEALKLYDTKLNLSLTEDKRIIKRSLENNKTENDYVFIVGLENDVVVSLATAHYEATTNSAFLIYLFAKDLPNHDELMTQTLHQIEHELNLLSNLVHSRSINFLMMEVPKEPADLTQDNGLIIEHRRQFLYEHQFERQTEIDYIHPTNDGHTKKVDLFLKKNIKLTKDIYGTSVKSNYILKYVFANGIAREIIYALLEETDLRKPF
>NC_022604.1|WP_000763768.1|432032_432440_-|hypothetical-protein
MADITVVNDTGELYNVINQKKSEGYLESELTIISKSKLHLNDLHDSEISLISTSGTFSDRMTKLLTGEDGEHAVLSRYNLAPDELEKYKQLILDDKMLVVAVRDKSSHQEVHENNSAYEEIDITHFAEASKGPKA
>NC_022604.1|WP_000421410.1|432952_433531_+|xanthine-phosphoribosyltransferase
MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVGEE
>NC_022604.1|WP_000793010.1|433530_434799_+|purine-permease
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILLLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIESTGVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEENVQ
>NC_022604.1|WP_000264071.1|434836_436303_+|IMP-dehydrogenase
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSF
>NC_022604.1|WP_000424966.1|436327_437869_+|glutamine-hydrolyzing-GMP-synthase
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCRGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
>NC_022604.1|WP_000237797.1|437936_439130_-|site-specific-integrase
MVKDPIKKAKNGTYYFRANLGYDSKGKKIQKYRSGFTTKKEAREEYSKLLLMKPEELSENKDKMTFKHYIFEIFLPWYKTQVKLRTYENRLPTIKKHFSYFDKMAVSDIEPIDVQNWQLKLSKKCKSSYVRAVQGLFSVAMDRAIVLGITTTNPSKIIGNVKKQKSKIEFWTKEEFEKVISLIYKEDYYQHFLFISLWFLFMTGMRIGEATAIQWEDIDFDSGVLTINKTLYYKNQSNYRFVEPKTKASVRHIVLDKCTLTYLSEWKEVQQNLIQTDFVMSYNGIPTQKHTLSYAIERYAKLAGIHRIRIHGLRHSHASLLISMGENPLIIKDRLGHEDIETTLGTYGHLYPNSNFEVANKLNGAISFKEAKQNYDTSPKNQFTVDYLRNKEMKKVQ
>NC_022604.1|WP_000633907.1|439156_439357_-|DUF3173-family-protein
MITVTKKDLVELGYGTSFSADIIKKAKELMITKGHIYYQSRKLDRVPREAVEEILGIRFSNENRSE
>NC_022604.1|WP_000845143.1|439854_440085_-|helix-turn-helix-domain-containing-protein
MKTAYPRVPFPLIVKATDGDVEAINQIVKHYRGYTSKRSLRRMTDEYGNSHMVIDETLRGRMETKLISKILSFEIK

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Crispr_ID: NC_022604_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022604_2

698290-698382

Orphan

Consensus_repeat	Method
CTAAAGGTGAAGAGGAACGCAGTTGGATGCTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022604_2

>merge|NC_022604|2|698290-698382|CRISPRCasFinder
CTAAAGGTGAAGAGGAACGCAGTTGGATGCTAAGGCACAACTGCATAAAAGCCTCTAATCGCTAAAGATGAAGAGGAACGCAGTTGGATGCTA

>NC_022604|2|2|698290-698382|CRISPRCasFinder
CTAAAGGTGAAGAGGAACGCAGTTGGATGCTA	AGGCACAACTGCATAAAAGCCTCTAATCG
CTAAAGATGAAGAGGAACGCAGTTGGATGCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022604.1\|WP_001018677.1\|704721_705096_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|130944
NC_022604.1\|WP_000735558.1\|702129_702636_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_001819741.1\|695006_695390_+\|DUF1934-family-protein	unknown	unknown	gnl\|CDD\|226896
NC_022604.1\|WP_000365354.1\|700490_701210_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NC_022604.1\|WP_001553862.1\|706043_706973_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|225778
NC_022604.1\|WP_001045421.1\|703682_704471_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_022604.1\|WP_001813976.1\|698510_699338_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238563
NC_022604.1\|WP_000633782.1\|690124_690661_+\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NC_022604.1\|WP_000477504.1\|690829_691306_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_022604.1\|WP_001021145.1\|695386_697048_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234964
NC_022604.1\|WP_001790232.1\|699485_700436_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_022604.1\|WP_000169042.1\|707167_707392_-\|DUF2922-domain-containing-protein	unknown	unknown	gnl\|CDD\|378571
NC_022604.1\|WP_000655099.1\|694773_694881_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000901764.1\|697436_698072_+\|endonuclease-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|225140
NC_022604.1\|WP_000808902.1\|688975_689914_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381309
NC_022604.1\|WP_001788287.1\|692668_693190_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378039
NC_022604.1\|WP_000362972.1\|701193_701994_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_022604.1\|WP_001222133.1\|702797_703514_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000180231.1\|691345_692641_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004
NC_022604.1\|WP_001200748.1\|693688_694699_+\|alcohol-dehydrogenase-AdhP	unknown	unknown	gnl\|CDD\|181842

Protein	Function_ID	Function_description	E-value
NC_022604.1\|WP_001018677.1\|704721_705096_-\|transcriptional-regulator	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	1.77309e-26
NC_022604.1\|WP_001553862.1\|706043_706973_-\|DMT-family-transporter	gnl\|CDD\|225778	COG3238, COG3238, Uncharacterized protein conserved in bacteria [Function unknown].	7.93315e-37
NC_022604.1\|WP_001819741.1\|695006_695390_+\|DUF1934-family-protein	gnl\|CDD\|226896	COG4506, COG4506, Uncharacterized protein conserved in bacteria [Function unknown].	9.50091e-54
NC_022604.1\|WP_000365354.1\|700490_701210_+\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	3.6864e-38
NC_022604.1\|WP_001813976.1\|698510_699338_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238563	cd01143, YvrC, Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	1.32108e-72
NC_022604.1\|WP_000633782.1\|690124_690661_+\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	3.16348e-26
NC_022604.1\|WP_000477504.1\|690829_691306_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.13315e-11
NC_022604.1\|WP_001021145.1\|695386_697048_+\|arginine--tRNA-ligase	gnl\|CDD\|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	0
NC_022604.1\|WP_001790232.1\|699485_700436_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	5.19191e-48
NC_022604.1\|WP_001045421.1\|703682_704471_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.55978e-34
NC_022604.1\|WP_000901764.1\|697436_698072_+\|endonuclease-III-domain-containing-protein	gnl\|CDD\|225140	COG2231, COG2231, Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair].	3.98158e-90
NC_022604.1\|WP_000808902.1\|688975_689914_+\|aldo/keto-reductase	gnl\|CDD\|381309	cd19083, AKR_AKR11A1_11D1, AKR11A and AKR11D families of aldo-keto reductase (AKR). Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).	7.3194e-168
NC_022604.1\|WP_001788287.1\|692668_693190_+\|hypothetical-protein	gnl\|CDD\|378039	pfam08741, YwhD, YwhD family. This family of proteins are currently uncharacterized. They are around 170 amino acids in length.	8.7406e-98
NC_022604.1\|WP_000362972.1\|701193_701994_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.35732e-24
NC_022604.1\|WP_000169042.1\|707167_707392_-\|DUF2922-domain-containing-protein	gnl\|CDD\|378571	pfam11148, DUF2922, Protein of unknown function (DUF2922). This bacterial family of proteins has no known function.	1.74707e-13
NC_022604.1\|WP_000180231.1\|691345_692641_+\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	3.76825e-150
NC_022604.1\|WP_001200748.1\|693688_694699_+\|alcohol-dehydrogenase-AdhP	gnl\|CDD\|181842	PRK09422, PRK09422, ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional.	0

>NC_022604.1|WP_000901764.1|697436_698072_+|endonuclease-III-domain-containing-protein
MLGTDELYKVLYEHLGPQFWWPADNDIEMMLGAILVQNTRWRNAEIALNQIKEHTHFNPNHILELPIETLQSLIHSSGFYKSKSLTIKTLLTWLARHHFNYQEINERYKGGLRKELLSLKGIGSETADVLLVYIFGRIEFIPDSYTRKIYDKLGYENTKNYDQLKKVVTLPNHFTNQDANEFHALLDVFGKHYFRDKDIKNYDFLEPYFKK
>NC_022604.1|WP_001021145.1|695386_697048_+|arginine--tRNA-ligase
MNIIDQVKQTLVEEIAASINKAGLADEIPDIKIEVPKDTKNGDYATNIAMVLTKIAKRNPREIAQAIVDNLDTEKAHVKQIDIAGPGFINFYLDNQYLTAIIPEAIEKGDQFGHVNESKGQNVLLEYVSANPTGDLHIGHARNAAVGDALANILTAAGYNVTREYYINDAGNQITNLARSIETRFFEALGDNSYSMPEDGYNGKDIIEIGKDLAEKHPEIKDYSEEARLKEFRKLGVEYEMAKLKNDLAEFNTHFDNWFSETSLYEKGEILEVLAKMKELGYTYEADGATWLRTTDFKDDKDRVLIKNDGTYTYFLPDIAYHFDKVKRGNDILIDLFGADHHGYINRLKASLETFGVDSNRLEIQIMQMVRLMENGKEVKMSKRTGNAITLREIMDEVGVDAARYFLTMRSPDSHFDFDMELAKEQSQDNPVYYAQYAHARICSILKQAKEQGIEVTAANDFTTITNEKAIELLKKVADFEPTIESAAEHRSAHRITNYIQDLASHFHKFYNAEKVLTDDIEKTKAHVAMIEAVRITLKNALAMVGVSAPESM
>NC_022604.1|WP_001819741.1|695006_695390_+|DUF1934-family-protein
MLKQHNEKEKFEFTTEGTWQQRQSNFIRYVEQIEDATVNVTIKVDDDSVKLIRKGDINMNLHFVEGQTTTTFYDISAGRIPLEVKTLRILHFVSGDGGKLKIHYELYQDNEKMGSYQYEINYKEIGE
>NC_022604.1|WP_000655099.1|694773_694881_+|hypothetical-protein
MKDSENLVFFGFEVLFVFYKMAYIYEALIKYGIVN
>NC_022604.1|WP_001200748.1|693688_694699_+|alcohol-dehydrogenase-AdhP
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
>NC_022604.1|WP_001788287.1|692668_693190_+|hypothetical-protein
MEVISLSEKKGFNFNIIKNDPLDGHKGTNIGSISLDNIAPVFIDVANKEAFIDIGGMHARAKVEKGVKWITDKAAVEGDEAKEYWLCWVTTERNEQGPYYAGLTACYLLVNKAIRRGYKSMPEHVNMMDKSMKHHIIIDQIGDENKAILKDFLMNHDEGMWKHSSDALHQAFN
>NC_022604.1|WP_000180231.1|691345_692641_+|HD-domain-containing-protein
MTNAYVDLKLVEEKVFKDPIHRYIHVEDQLIWDLIKTKEFQRLRRIRQLGTLYLSFHTAEHSRFGHSLGVYEIVRRLIDESFIGHDAWDNKDRPLALCAALLHDLGHGPFSHSFEKIFNTDHEAYTQAIITGDTEVNAVLRKVAPEFPREVAEVINKTHHNKLVISMISSQIDADRMDYLQRDAYFTGVSYGAFDMERILRLMRPSKDEVLIKESGMHAVENFIMSRYQMYWQIYFHPVSRGGEVLLNNCLKRAKQLYNEGYEFKLHPHDFIPFFEETVTIEQYVELDEAVVTYYLEKWTKEDDAILSDLASRFINRDLFKYIPFDGSIITISELQELFEAGGINPDYYFVSEAFSDLPYDYDRPGSNRKPIHLLRQYGTIREISNQSLVIHSITGINRQDYKLYYPREMVAKIKDKTIREAIENLINELN
>NC_022604.1|WP_000477504.1|690829_691306_+|GNAT-family-N-acetyltransferase
MFKVRQATEKDVVQIRDVATKAWFNTYLNIYAATTVNHLLEASYNEHHLKKRLQEQLFLVVEEGNDIVGFANFIYGEELYLSAHYVKPESQHTGYGTALLNEGLSRFEDKFEGVYLEVDNKNEEAVAYYKEQGFTILRSYEPEMYGEKLDLALMYKAF
>NC_022604.1|WP_000633782.1|690124_690661_+|flavodoxin-family-protein
MITVLFGGSRPNGNTAQLTKFALQDLEYQWIDVTQHQFKPIRDVRHTAETITSYDDDYLPILDKILASDTIIFASPVYWYSISAPLKAFIEHWSETLQDKRYPNFKAQMAEKDFRVILVGGDCPKIKAKPAITQMKYSLDFLGATLNGYIIGTAEKPGDIMKDNYALARATEWNSILQ
>NC_022604.1|WP_000808902.1|688975_689914_+|aldo/keto-reductase
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYGPERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDNNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYVDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEENVRRVKALESIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDEIQYIDELFPIED
>NC_022604.1|WP_001813976.1|698510_699338_+|ABC-transporter-substrate-binding-protein
MKDNDKQGSNDNGSSKSPYHRIVSLMPSNTEILYELGLGKYIVGVSTVDDYPKDVKKGKKQFDALNLNKEELLKAKPDLILAHESQKATANKVLSSLEKQGIKVVYVKDAQSIDETYNTFKQIGKLTHHDKQAEQLVEETKDNIDKVIDSIPAHHKKSKVFIEVSSKPEIYTAGKHTFFNDMLEKLEAQNVYSDINGWNPVTKESIIKKNPDILISTEAKTRSDYMDIIKKRGGFNKINAVKNTRIEVVNGDEVSRPGPRIDEGLKELRDAIYRK
>NC_022604.1|WP_001790232.1|699485_700436_+|iron-ABC-transporter-permease
MTFNKVLLSWIVILIITTSIYLFWQLGDINDVFNQSILINVRLPRLLEALLTGMILTVAGLIFQTVLNNALADSFTLGLASGATFGSGLALFLGLTTLWIPVFSITFSLITLITVLVITSVLSQGYPVRILILSGLMIGALFNSLLYFLILLKPRKLNTIANYLFGGFGDAEYSNVSIIAITFIIALFGIFIILNQLKLLQLGELKSQSLGLNVQLITYIALCIASMITAINVAYVGIIGFIGMVIPQLIRKWQWKQSLGRQLALNIVTGGQIMVMADFIGSHILSPVQIPASIIIALIGIPVLFYMLISQSKRLH
>NC_022604.1|WP_000365354.1|700490_701210_+|HAD-family-hydrolase
MDLNQIKAVVFDLEGTLLDRVKSREKFIEEQYERFHDYLIHVQLADFKKAFIELDDDEDNDKPDLYKEIIKRFHVDRLTWKDLFNDFEMHFYRYVFPYYDTLYTLEKLSQKGFQIGVIANGKSKIKQFRLHSLGLMHVINYLSTSETVGFRKPHPKIFEDMIDQLGVLPEQIMYVGDDALNDVAPARAMGMVSVWYKQEDAEIEPLEEEVDFTITTVEELLTILPIKNDNKGENYGSIY
>NC_022604.1|WP_000362972.1|701193_701994_+|alpha/beta-hydrolase
MDLFTRKDGTSIHYSTLGEGYPIVLIHTVLDNYSVFNKLAAELAKSFQVVLIDLRGHGYSDKPRHIEIKDFSDDIVELLKYLYIEEVAFVCHEMSGIIGADISVRYPEFTSSLTLVNPTSIEGELPEERLFRKYAHIIRNWDPEKQDKFLNKRKYYRPRKMNRFLKHVVDTNEISTKEEIQAVKEVFKNADISQTYRNVVVPTKIIAGEFGERTTRLEAKEVADLIQNADFEVYQESSAFPFVEEQERFVEDTAAFINKHHDEKHV
>NC_022604.1|WP_000735558.1|702129_702636_+|hypothetical-protein
MKKLLTASIIACSVVMGVGLVNTSAEAASGNSIDTVKQLIKGDQSLENVKIGESIKDVLTKYKNPMYSYNEDGTEHYYEFHTKKGMLLVTTDGKKNNGKVTHISMMYNDANGPTYQAVKNYVGKAVTHTEYSKVAGNFGYIEKGKTTYQFASAPKDKNIKLYRIDLEK
>NC_022604.1|WP_001222133.1|702797_703514_+|hypothetical-protein
MRINDKILLENIEDYFNHKGLSPHLIDDIKEKVITDIKNSEKKDQDYIEYKRKSPAQIILMIQRNLFALQMNPVIFFIINFILISYLYDKQYVQFQAITGMSLFYCLVIFPMTIVVYLRVSQKNYLRSNKIEMIMGTIIAIISLLLIILQAFNITWGVIPITNFGHQFFFFIGIILVIAGIFYKRLEFSGIGLLFCQKTVDAMIHNPQSAQIFSLIIWILLVVLVIYFTIRLSSRTRL
>NC_022604.1|WP_001045421.1|703682_704471_+|alpha/beta-hydrolase
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKSSKSESYDLNDHVEDLKILMEKLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKKDDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEKTMKWYQKQRIYSIKSEDDSAVAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLEAHFLNVTKKIFEHSGHAPHIEEPEAFMNYYLKFLKSVS
>NC_022604.1|WP_001018677.1|704721_705096_-|transcriptional-regulator
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
>NC_022604.1|WP_001553862.1|706043_706973_-|DMT-family-transporter
MLLFYIIGVLVGMLIPIQTSVNSRLSLYTKSPFYTSFISFSVGTICLIILNIIINPEVFTIHFYNNQSFNYTWVVGGLLGVSFLTGNLLLLPKLGATLTVIATVAGQIIMGVIIDTFGLFGATIHDFNLIKAIGVLLLIVGIVIMNQFNKNNLLLTDQKYLLFWLLLGFIFGFFPPIQTTINSALASHTHSPAFASLVSFTIGSIALLILTAIFNRSLKLKTSHLKFGKLKPIYFTGGILGMAFVTANIILMPHMGAALTTLIGMFGQILMGILIDHFGLFGSPKIAMTSRKTIGLLCILTGIILLRLF
>NC_022604.1|WP_000169042.1|707167_707392_-|DUF2922-domain-containing-protein
MTKTLELSFKSSLDKPVKLQLPQLNNVVTEQVARDSMNALVDLNIIKSNSGTITKVHSAQIIDKTTTVLFEDKK

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Crispr_ID: NC_022604_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022604_3

814035-814117

Orphan

Consensus_repeat	Method
CCAATTTCTACAGACAATGCAAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022604_3

>merge|NC_022604|3|814035-814117|CRISPRCasFinder
CCAATTTCTACAGACAATGCAAGTTGGCGGGGCCCCAACATAGAGAAATTGGAACGCCAATTTCTACAGACAATGCAAGTTGG

>NC_022604|3|3|814035-814117|CRISPRCasFinder
CCAATTTCTACAGACAATGCAAGTTGG	CGGGGCCCCAACATAGAGAAATTGGAACG
CCAATTTCTACAGACAATGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022604.1\|WP_000429014.1\|814565_815483_-\|diacylglycerol-kinase-family-lipid-kinase	unknown	unknown	gnl\|CDD\|224513
NC_022604.1\|WP_000930014.1\|817598_818099_-\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	unknown	unknown	gnl\|CDD\|223851
NC_022604.1\|WP_001068497.1\|818118_818985_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_022604.1\|WP_000663030.1\|811934_812993_+\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|235106
NC_022604.1\|WP_000499195.1\|823854_824010_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000983677.1\|807207_808989_+\|DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|273594
NC_022604.1\|WP_000193751.1\|815752_817258_-\|peptide-MFS-transporter	unknown	unknown	gnl\|CDD\|225646
NC_022604.1\|WP_000589260.1\|809210_810188_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224050
NC_022604.1\|WP_000708692.1\|800929_801640_+\|allophanate-hydrolase-subunit-1	unknown	unknown	gnl\|CDD\|224960
NC_022604.1\|WP_000876318.1\|824048_825020_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226965
NC_022604.1\|WP_001790169.1\|800635_800842_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_001790641.1\|815573_815675_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000098285.1\|803101_805042_+\|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS	unknown	unknown	gnl\|CDD\|224287
NC_022604.1\|WP_000197271.1\|813343_813886_+\|5'-3'-deoxyribonucleotidase	unknown	unknown	gnl\|CDD\|226895
NC_022604.1\|WP_000855505.1\|820146_822252_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|236069
NC_022604.1\|WP_000022323.1\|801623_802628_+\|biotin-dependent-carboxyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224895
NC_022604.1\|WP_000180991.1\|810180_811695_+\|ABC-transporter-permease/substrate-binding-protein	unknown	unknown	gnl\|CDD\|270328
NC_022604.1\|WP_000692521.1\|819785_820184_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	unknown	unknown	gnl\|CDD\|224694
NC_022604.1\|WP_000562498.1\|822369_823341_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|275027
NC_022604.1\|WP_000525109.1\|805312_807196_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562

Protein	Function_ID	Function_description	E-value
NC_022604.1\|WP_000429014.1\|814565_815483_-\|diacylglycerol-kinase-family-lipid-kinase	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	3.10512e-78
NC_022604.1\|WP_000930014.1\|817598_818099_-\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	gnl\|CDD\|223851	COG0780, COG0780, Enzyme related to GTP cyclohydrolase I [General function prediction only].	7.91282e-79
NC_022604.1\|WP_001068497.1\|818118_818985_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	3.8323e-10
NC_022604.1\|WP_000663030.1\|811934_812993_+\|histidinol-phosphate-transaminase	gnl\|CDD\|235106	PRK03158, PRK03158, histidinol-phosphate aminotransferase; Provisional.	0
NC_022604.1\|WP_000983677.1\|807207_808989_+\|DNA-helicase-RecQ	gnl\|CDD\|273594	TIGR01389, recQ, ATP-dependent DNA helicase RecQ. The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_022604.1\|WP_000193751.1\|815752_817258_-\|peptide-MFS-transporter	gnl\|CDD\|225646	COG3104, PTR2, Dipeptide/tripeptide permease [Amino acid transport and metabolism].	1.22605e-172
NC_022604.1\|WP_000589260.1\|809210_810188_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	4.80291e-155
NC_022604.1\|WP_000708692.1\|800929_801640_+\|allophanate-hydrolase-subunit-1	gnl\|CDD\|224960	COG2049, DUR1, Allophanate hydrolase subunit 1 [Amino acid transport and metabolism].	1.29969e-94
NC_022604.1\|WP_000876318.1\|824048_825020_+\|ABC-transporter-permease	gnl\|CDD\|226965	COG4606, CeuB, ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism].	1.32603e-150
NC_022604.1\|WP_000098285.1\|803101_805042_+\|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	0
NC_022604.1\|WP_000197271.1\|813343_813886_+\|5'-3'-deoxyribonucleotidase	gnl\|CDD\|226895	COG4502, COG4502, 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism].	1.15481e-107
NC_022604.1\|WP_000855505.1\|820146_822252_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|236069	PRK07632, PRK07632, ribonucleotide-diphosphate reductase subunit alpha; Validated.	0
NC_022604.1\|WP_000022323.1\|801623_802628_+\|biotin-dependent-carboxyltransferase-family-protein	gnl\|CDD\|224895	COG1984, DUR1, Allophanate hydrolase subunit 2 [Amino acid transport and metabolism].	1.25641e-144
NC_022604.1\|WP_000180991.1\|810180_811695_+\|ABC-transporter-permease/substrate-binding-protein	gnl\|CDD\|270328	cd13610, PBP2_ChoS, Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; type 2 periplasmic-binding protein fold. Osmoprotectant binding lipoprotein ChoS of Lactococcus lactis is predicted to be involved in uptake of compatible solutes such as choline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ChoS belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.03165e-152
NC_022604.1\|WP_000692521.1\|819785_820184_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	gnl\|CDD\|224694	COG1780, NrdI, Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism].	5.52807e-56
NC_022604.1\|WP_000562498.1\|822369_823341_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	gnl\|CDD\|275027	TIGR04171, ribonucleotide-diphosphate_reductase_subunit_beta, ribonucleoside-diphosphate reductase, class 1b, beta subunit. Members of this family are NrdF, the beta subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	2.30551e-164
NC_022604.1\|WP_000525109.1\|805312_807196_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0

>NC_022604.1|WP_000197271.1|813343_813886_+|5'-3'-deoxyribonucleotidase
MTRKSIAIDMDEVLADTLGEIIDAVNFRADLGIKMEALNGQKLKHVIPEHDGLITEVLREPGFFRHLKVMPYAQEVVKKLTEHYDVYIATAAMDVPTSFSDKYEWLLEFFPFLDPQHFVFCGRKNIVKADYLIDDNPRQLEIFTGTPIMFTAVHNINDDRFERVNSWKDVEQYFLDNIEK
>NC_022604.1|WP_000663030.1|811934_812993_+|histidinol-phosphate-transaminase
MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQSRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPNNPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAIEKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNFIFVKTKRVNELYEALLNVGCITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE
>NC_022604.1|WP_000180991.1|810180_811695_+|ABC-transporter-permease/substrate-binding-protein
MTNFFDILSERKGQLFSTMIEHIQISFIALLIATAIAVPLGILLTKTKTISEIVMNIAAILQTIPSLALLGLMIPLFGIGRVPAIIALVVYALLPILRNTYTGIKEVDPSLIEAAKGIGMKPFRRLTKVELPIAMPVIMAGVRTAMVLIIGTATLAALIGAGGLGDLILLGIDRNNASLILLGAIPAALLAIIFDLILRFMAKLSYKKLLMTLGVIVMIIILAIAIPMFAQKGDKITLAGKLGSEPSIITNMYKILIEEETKNTVEVKDGMGKTAFLFNALKSDDIDGYLEFTGTVLGELTKEPLKSKEEKKVYEQAKQSLEKKYQMTMLKPMKYNNTYALAVKRDFAKQHNIRTIGDLNKVKDQLKPGFTLEFNDRPDGYKAVQKAYNLNLDNIRTMEPKLRYQAINKGNINLIDAYSTDAELKQYDMVVLKDDKHVFPPYQGAPLFKESFLKKHPEIKKPLNKLENKISDEDMQMMNYKVTVKNEDPYTVAKDYLKAKGLIK
>NC_022604.1|WP_000589260.1|809210_810188_+|ABC-transporter-ATP-binding-protein
MIKFKNVTKRYGKHVAVDNISFNINEGEFFVLIGPSGCGKTTTLKMINRLIHLSEGYIYFKDKPISDYPVYEMRWDIGYVLQQIALFPHMTIKENIAQVPQMKKWKEKDIDKRVDELLEMVGLEPEKYKNRKPDELSGGQRQRVGVIRALAADPPVILMDEPFSALDPISREKLQDDLIELQTKIKKTIIFVTHDIQEAMKLGDKICLLNEGHIEQIDTPEGFKNNPQSEFVKQFMGSHLEDDAPCVEENAIIRDLDIMKPIDEVTSMSAYPIVYDNQPIEVLYQLLSESERVIVMQEDSVGQYVIDRKDIFKYLSQKKEVAQHD
>NC_022604.1|WP_000983677.1|807207_808989_+|DNA-helicase-RecQ
MMQQTLSHYFGYETFRPGQEEIISKVLDHRNVLGVLPTGGGKSICYQVPGLLLGGTTIVISPLISLMKDQVDQLKAMGIQAAFLNSSLTQKEQQRIEKALSNGEIQFLYVAPERFENRYFLNMLQRIKIHLVAFDEAHCISKWGHDFRPSYQNVISKVFTLPQDFTIIALTATATVEVQQDIREKLNIAQTDQIKTSTKRRNLIFKVNPTYQRQKFILDYIKTHDEDAGIIYCSTRKQVEELQEALESQKIESVIYHAGLSNKEREEAQNDFLFDRVKVVVATNAFGMGIDKSNVRFVIHYNMPGDLESYYQEAGRAGRDGLKSECILLFSERDINLHEYFITVSQADDDYKDKMGEKLTKMIQYTKTKKCLEATIVHYFEPNEKLEECEQCSNCVQQDKSYNMTQEAKMIISCIARMKQQESYSVIIQVLRGESTDYIKYKGYDQISTHGLMKGYTTSELSHLIDELRFKGFLNENDEILMCDTSIKKLLSNEVEVFTTPFKQKATEKVFINTVEGVDRVLFSQLVEVRKKLSDKLTIAPVSIFSDYTLEEFAKRKPASKQDMINIDGVGSYKLKHYCPAFLETIQNYKAKV
>NC_022604.1|WP_000525109.1|805312_807196_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MGMEAYKIEHLNKSYADKTIFDNLDLSISEGEKIGLVGINGTGKSTLLKVIGGIDDDFTANVMHPNQYRIRYSSQKQDLNEDMTVFDAVLSSDTTTLRIIKQYEQAVQAYADDQSDKLFKRMMDAQDAMDQHDAWDYNAEIKTILSKLGIHDTTKYIKELSGGQQKRVVLAKTLIEQPDLLLLDEPTNHLDFESISWLINYVKQYPHTVLFVTHDRYFLNEVSTRIIELNRGKLASYPGNYESYIEMRAEREVTLQKQQQKQRALYKEELAWMRAGAKARTTKQQARINRFNDLENEVNQQYKDDKGELNLAYSRLGKQVFELEDLSKAINDKVLFEHLTEIIQKGERIGVVGPNGAGKTTLLNILSGEDQQFEGKLKTGQTVKVAYFKQTDETLDRDIRMIDYLREENEIAKEKDGTSVSITQLLERFLFPSATHGKKVYKLSGGEQKRLYLLRLLVHQPNVLLLDEPTNDLDTETLTILEDYIHTFGGTVITVSHDRYFLNKVAQSYWFIHDGQMEKIIGTFEDYESYKKSLDKNKSTLKQQSKSSTTVRKKNGLSYKEKLEYEQLMKRIEQAEVRMEEIDVLMIEASADYGKIKELNEEKEQLEIQYDLDITRWSELEEIKEQQ
>NC_022604.1|WP_000098285.1|803101_805042_+|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS
MSSQKKKISLFAFFLLTVITITLKTYFSYYVDFSLGVKGLVQNLILLMNPYSLVALVLSVFLFFKGKKAFWFMFIGGFLLTFLLYANVVYFRFFSDFLTFSTLNQVGNVESMGGAVSASFKWYDFVYFIDTLVYLFILIFKTKWLDTKAFSKKFVPVVMAASVALFFLNLAFAETDRPELLTRTFDHKYLVKYLGPYNFTVYDGVKTIENNQQKALASEDDLTKVLNYTKQRQTEPNPEYYGVAKKKNIIKIHLESFQTFLINKKVNGKEVTPFLNKLSSGKEQFTYFPNFFHQTGQGKTSDSEFTMDNSLYGLPQGSAFSLKGDNTYQSLPAILDQKQGYKSDVMHGDYKTFWNRDQVYKHFGIDKFYDATYYDMSDKNVVNLGLKDKIFFKDSANYQAKMKSPFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDGYIQTARYLDEALEEYINDLKKKGLYDNSVIMIYGDHYGISENHNNAMEKLLGEKITPAKFTDLNRTGFWIKIPGKSGGINNEYAGQVDVMPTILHLAGIDTKNYLMFGTDLFSKGHNQVVPFRNGDFITKDYKYVNGKIYSNKNNELITTQPADFEKNKKQVEKDLEMSDNVLNGDLFRFYKNPDFKKVNPSKYKYETGPKANSKK
>NC_022604.1|WP_000022323.1|801623_802628_+|biotin-dependent-carboxyltransferase-family-protein
MSIIIEKSGLFSSFQDFGRRGYEHDGVIPCGALDTLAHEIANRLVANDKNEATLEMTNKMATIRFTEPTLIALAGGNVKAYTEHMTISPYKLYLLDKGDVLKFRETSYTSRVYLAVGGGFELDAWLGSNSTDFNVKIGGFKGRTLQDGDEIKLKRDYTARHHKLFENLAHTKQTDWGIDGYALSFNYMSDVFHVVKNKGTEDFKEDAIQRFVKHDYKVTSKANRMGMMLEGEKIKAFYEDMPPYQTVKKGTIQIKRDGTPIILLNDHYTLGSYPQIGTIASYHLTKLAQKPQGSRLKFQFIDILTAEKNLVKYSNWLNQLFHGIEYRMQLEMMK
>NC_022604.1|WP_000708692.1|800929_801640_+|allophanate-hydrolase-subunit-1
MKIYSQGDQAIVVAIEKEVSKSLTEDLLTLRSYLIEQNYPFIIEIVPSESDMMIVYDARDMIKHHNIQSPFLYMKALIESIHLNIKHDFNQQDLIEIPIVYGSKYGPDLESLLKHYKIKLETFIELHSKAQYFVSMMGYSPGFPYLTGLNKKLYINHTSKQKKFIPAGSVVLEGKKCGIVTTDTINDWLVIGYTPLSLFNPKESDFARLKLGDNIKFRPINENELEVGAFKDVNHN
>NC_022604.1|WP_001790169.1|800635_800842_+|hypothetical-protein
MIIVYIVLLLILVYVNYRLVNRLLSENRIYVVRLIATITTVISFILVYALIHELMPFVVRAMDLMYHQ
>NC_022604.1|WP_000429014.1|814565_815483_-|diacylglycerol-kinase-family-lipid-kinase
MENKYTHGVLFYHEHSGLKNINQGIGEVTTALSSICKHLSIQLSENEGDIIKYCQEIKTKNYAKDVDILFILGGDGTVNELINGVMTHDLQLPIGILPGGTFNDFTKTLNIAPNHKQASEQMISAQVGTYDVIKINNQYALNFVGLGLIVQNAENVQDGSKDIFGKLSYIGSTVKTLLNPTQFNYQLSIDDKTYSGETTMILTANGPFIGGSRIPLTDLSPQDGELNTFIFNEQSFSILNDIFKKRDSMNWNEITQGIEHIPGKKISLTTDPAMKVDIDGEISLETPIDIEVIPNAIQLLTVNDL
>NC_022604.1|WP_001790641.1|815573_815675_+|hypothetical-protein
MVINEIDFYRVGRENIVIAVYNEHIKFLFILIS
>NC_022604.1|WP_000193751.1|815752_817258_-|peptide-MFS-transporter
MTQQNSHGNQIQDIPQTGFFGHPRGLGVLFFVEFWERFSYYGMRALLIFYMYFAVTDNGLGIDKTTAMSIMSVYGSLIYMTSIPGGWIADRITGTRGATLLGAVFIIIGHICLSLPFALIGLFTSMFFIIIGSGLMKPNISNIVGRLYPENDRRMDAGFVIFYMSVNMGALLSPIILQHFVNVKNFHGGFLIAAVGMALGLVWYVLFNRKNLGSVGMKPTNPLTPAEKKKYGLIIGSVVLAIVLIIVIGALTNSLSFNLVSNTVLVLGIALPIIYFTLIIRSKDVTDTERSRVKAFIPLFILGMVFWAIQEQGSNVLNIYGIEHSDMKLNLFGWKTNFGEAIFQSINPLFILLLAPIISLLWQKLGTKQPSLPVKFAIGTFLAGASYILIGIVGYASGSSNFSVNWVILSYIICVIGELCLSPTGNSAAVKLAPKAFNAQMMSIWYLTNASAQAINGTLVKLIEPLGQTNYFIFLGVVAIIVTTIVLAFSPLIIKAMKGIR
>NC_022604.1|WP_000930014.1|817598_818099_-|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF
MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPITGQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEVWGKFTPRGGISIDPYTNYGRPNSKYEKMAEHRLMNHDLYPEKIDNR
>NC_022604.1|WP_001068497.1|818118_818985_-|DMT-family-transporter
MNPKVKGIIAILISAIGFSFMSVFFRLAGDLPVFQKSLARNLVAMFIPLFFIYKYHQPMFGRLSSQPLLITRSTLGLIGVLLNIYAIDHMVLSDADSLMKLNPFWTILLSIVFLHEKVRKYQITAMIIAILGMLLIVKPEFSSSMIPSLAGLFSGIFAASAYTCVRALSTREAPYTIVFYFSLFSVIVLIPFTAYTYEPMSQMQILYLLGAGLAAAVGQIGVTLAYSFAAAKDISIFTYASIIFTAILGFILFGESPDFYATLGYVVIIGASYYMFEKARRDAKIIKK
>NC_022604.1|WP_000692521.1|819785_820184_+|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI
MKIIYFSFTGNVRRFIKRTELENTLEITAENCMEPVHEPFIIVTGTIGFGEVPEPVQSFLEVNHQYIRGVAASGNRNWGLNFAKAGRTISEEYNVPLLMKFELHGKNKDVIEFKNKVGNFNENHGREKVQSY
>NC_022604.1|WP_000855505.1|820146_822252_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha
MKTMEEKKYNHIELNNEVTKRREDGFFSLEKDQEALVAYLEEVKDKTIFFDTEIERLRYLVDNDFYFNVFDIYSEADLIEITDYAKSIPFNFASYMSASKFFKDYALKTNDKSQYLEDYNQHVAIVALYLANGNKAQAKQFISAMVEQRYQPATPTFLNAGRARRGELVSCFLLEVDDSLNSINFIDSTAKQLSKIGGGVAINLSKLRARGEAIKGIKGVAKGVLPIAKSLEGGFSYADQLGQRPGAGAVYLNIFHYDVEEFLDTKKVNADEDLRLSTISTGLIVPSKFFDLAKEGKDFYMFAPHTVKEEYGVTLDDIDLEKYYDDMVANPNVEKKKKNAREMLNLIAQTQLQSGYPYLMFKDNANRVHPNSNIGQIKMSNLCTEIFQLQETSIINDYGIEDEIKRDISCNLGSLNIVNVMESGKFRDSVHSGMDALTVVSDVANIQNAPGVRKANSELHSVGLGVMNLHGYLAKNKIGYESEEAKDFANIFFMMMNFYSIERSMEIAKERGIKYQDFEKSDYANGKYFEFYTTQEFEPQFEKVRELFDGMAIPTSEDWKKLQQDVEQYGLYHAYRLAIAPTQSISYVQNATSSVMPIVDQIERRTYGNAETFYPMPFLSPQTMWYYKSAFNTDQMKLIDLIATIQTHIDQGISTILYVNSEISTRELARLYVYAHYKGLKSLYYTRNKLLSVEECTSCSI
>NC_022604.1|WP_000562498.1|822369_823341_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta
MIAVNWNTQEDMTNMFWRQNISQMWVETEFKVSKDIASWKTLSEAEQDTFKKALAGLTGLDTHQADDGMPLVMLHTTDLRKKAVYSFMAMMEQIHAKSYSHIFTTLLPSSETNYLLDEWVLEEPHLKYKSDKIVANYHKLWGKEASIYDQYMARVTSVFLETFLFFSGFYYPLYLAGQGKMTTSGEIIRKILLDESIHGVFTGLDAQHLRNELSESEKQKADQEMYKLLNDLYLNEESYTKMLYDDLGITEDVLNYVKYNGNKALSNLGFEPYFEEREFNPIIENALDTTTKNHDFFSVKGDGYVLALNVEALQDDDFVFDNK
>NC_022604.1|WP_000499195.1|823854_824010_+|hypothetical-protein
MFYFTLSKQNTHSEKLNFSLIANINKIDTKLFERLLKLWSKNATINEKYYQ
>NC_022604.1|WP_000876318.1|824048_825020_+|ABC-transporter-permease
MKYLLKGNILLLLLILLTIISLFIGVSELSIKDLLHLTESQRNILFSSRIPRTMSILIAGSSLALAGLIMQQMMQNKFVSPTTAGTMEWAKLGILIALLFFPTGHILLKLVFAVICSICGTFLFVKIIDFIKVKDVIFVPLLGIMMGGIVASFTTFISLRTNAVQSIGNWLNGNFAIITSGRYEILYLSIPLLALTYLFANHFTIVGMGKDFTNNLGLSYEKLINIALFITATITALVVVTVGTLPFLGLVIPNIISIYRGDHLKNAIPHTMMLGAIFVLFSDIVGRIVVYPYEINIGLTIGVFGTIIFLILLMKGRKNYAQQ

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Crispr_ID: NC_022604_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022604_4

855087-855167

Unclear

Consensus_repeat	Method
TTCTTTATGTTGGGGCCCCGCCAACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022604_4

>merge|NC_022604|4|855087-855167|CRISPRCasFinder
TTCTTTATGTTGGGGCCCCGCCAACTTGCATTGTTTGTAGAATTTCTTTTCGAAATTCTTTATGTTGGGGCCCCGCCAACT

>NC_022604|4|4|855087-855167|CRISPRCasFinder
TTCTTTATGTTGGGGCCCCGCCAACT	TGCATTGTTTGTAGAATTTCTTTTCGAAA
TTCTTTATGTTGGGGCCCCGCCAACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022604.1\|WP_000006551.1\|862959_863904_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NC_022604.1\|WP_000816295.1\|865306_866209_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NC_022604.1\|WP_000513308.1\|856341_857181_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NC_022604.1\|WP_001049165.1\|864476_865064_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NC_022604.1\|WP_001224793.1\|857188_857674_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NC_022604.1\|WP_000749380.1\|847792_848632_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_022604.1\|WP_000638419.1\|849452_849689_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NC_022604.1\|WP_000617735.1\|842441_843014_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NC_022604.1\|WP_001248939.1\|861854_862850_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NC_022604.1\|WP_001790092.1\|846000_846105_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000662681.1\|851950_854797_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_022604.1\|WP_000958224.1\|855403_856336_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NC_022604.1\|WP_000057549.1\|857681_859121_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NC_022604.1\|WP_000506532.1\|843427_845959_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_022604.1\|WP_000134963.1\|859187_860123_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_022604.1\|WP_000229253.1\|849957_851943_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_022604.1\|WP_000369732.1\|860946_861858_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NC_022604.1\|WP_001790093.1\|847537_847645_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000538141.1\|848805_849456_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NC_022604.1\|WP_010956549.1\|846273_847384_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799

Protein	Function_ID	Function_description	E-value
NC_022604.1\|WP_000006551.1\|862959_863904_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NC_022604.1\|WP_000816295.1\|865306_866209_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	4.94096e-153
NC_022604.1\|WP_001049165.1\|864476_865064_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NC_022604.1\|WP_001224793.1\|857188_857674_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
NC_022604.1\|WP_000749380.1\|847792_848632_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	2.23913e-42
NC_022604.1\|WP_000638419.1\|849452_849689_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NC_022604.1\|WP_000617735.1\|842441_843014_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.13584e-37
NC_022604.1\|WP_001248939.1\|861854_862850_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NC_022604.1\|WP_010956549.1\|846273_847384_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_022604.1\|WP_000662681.1\|851950_854797_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_022604.1\|WP_000958224.1\|855403_856336_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NC_022604.1\|WP_000057549.1\|857681_859121_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.31987e-06
NC_022604.1\|WP_000506532.1\|843427_845959_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_022604.1\|WP_000134963.1\|859187_860123_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NC_022604.1\|WP_000229253.1\|849957_851943_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_022604.1\|WP_000369732.1\|860946_861858_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	1.09727e-168
NC_022604.1\|WP_000538141.1\|848805_849456_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NC_022604.1\|WP_000513308.1\|856341_857181_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.39921e-119

>NC_022604.1|WP_000662681.1|851950_854797_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NC_022604.1|WP_000229253.1|849957_851943_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NC_022604.1|WP_000638419.1|849452_849689_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NC_022604.1|WP_000538141.1|848805_849456_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NC_022604.1|WP_000749380.1|847792_848632_+|CHAP-domain-containing-protein
MKKSLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVTKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NC_022604.1|WP_001790093.1|847537_847645_+|hypothetical-protein
MCLLKQHMQCAFSNITYGDFQGIELIIENVLNYMV
>NC_022604.1|WP_010956549.1|846273_847384_+|peptide-chain-release-factor-2
MELSEIKRNIDKYNQDLTQIRGSLDLENKETNIQEYEEMMAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDEEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDIGPFIESYLRQTMSHD
>NC_022604.1|WP_001790092.1|846000_846105_+|hypothetical-protein
MLWEESFYFTSVKYFKKCEEVVKRCYVLSFKKSV
>NC_022604.1|WP_000506532.1|843427_845959_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNESHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>NC_022604.1|WP_000617735.1|842441_843014_+|ribosome-associated-translation-inhibitor-RaiA
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
>NC_022604.1|WP_000958224.1|855403_856336_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NC_022604.1|WP_000513308.1|856341_857181_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGSVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NC_022604.1|WP_001224793.1|857188_857674_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NC_022604.1|WP_000057549.1|857681_859121_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDMEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDVMVAWINQGELIIAEKVDLSDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NC_022604.1|WP_000134963.1|859187_860123_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NC_022604.1|WP_000369732.1|860946_861858_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGVGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NC_022604.1|WP_001248939.1|861854_862850_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NC_022604.1|WP_000006551.1|862959_863904_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NC_022604.1|WP_001049165.1|864476_865064_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NC_022604.1|WP_000816295.1|865306_866209_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKALFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGIILSNEGGALQTMKLPYEYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE

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Crispr_ID: NC_022604_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022604_5

904955-905036

Orphan

Consensus_repeat	Method
CCCCAACTTGCATTGTCTGTAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022604_5

>merge|NC_022604|5|904955-905036|CRISPRCasFinder
CCCCAACTTGCATTGTCTGTAGAAATTGGGAATCCAATTTCTCTTTGTTGGGGCCCATCCCCAACTTGCATTGCCTGTAGAA

>NC_022604|5|5|904955-905036|CRISPRCasFinder
CCCCAACTTGCATTGTCTGTAGAA	ATTGGGAATCCAATTTCTCTTTGTTGGGGCCCAT
CCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022604.1\|WP_000732326.1\|908248_909070_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NC_022604.1\|WP_000660172.1\|903857_903971_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000150017.1\|900947_901664_+\|type-I-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|184156
NC_022604.1\|WP_000569884.1\|899484_899979_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|372596
NC_022604.1\|WP_001802951.1\|898079_898640_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NC_022604.1\|WP_000422909.1\|901746_902286_+\|nitroreductase	unknown	unknown	gnl\|CDD\|380312
NC_022604.1\|WP_000290485.1\|903413_903794_+\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NC_022604.1\|WP_000571218.1\|906517_907543_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NC_022604.1\|WP_001033317.1\|911273_912002_-\|staphylococcal-enterotoxin-type-Q	unknown	unknown	gnl\|CDD\|280949
NC_022604.1\|WP_001018962.1\|905592_905979_+\|topiosmerase	unknown	unknown	gnl\|CDD\|224572
NC_022604.1\|WP_000264182.1\|909213_910434_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_022604.1\|WP_023180111.1\|907535_908231_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NC_022604.1\|WP_001190695.1\|902435_902756_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_022604.1\|WP_000255561.1\|898712_899330_-\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NC_022604.1\|WP_000589549.1\|902899_903256_+\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NC_022604.1\|WP_000974460.1\|900377_900800_-\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NC_022604.1\|WP_001065801.1\|905971_906268_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_022604.1\|WP_001063624.1\|913060_913273_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379188
NC_022604.1\|WP_000142630.1\|912176_912911_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_022604.1\|WP_000733773.1\|910521_911250_-\|staphylococcal-enterotoxin-type-K	unknown	unknown	gnl\|CDD\|280949

Protein	Function_ID	Function_description	E-value
NC_022604.1\|WP_000732326.1\|908248_909070_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	2.15951e-112
NC_022604.1\|WP_000290485.1\|903413_903794_+\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	2.81086e-68
NC_022604.1\|WP_000150017.1\|900947_901664_+\|type-I-3-dehydroquinate-dehydratase	gnl\|CDD\|184156	PRK13575, PRK13575, type I 3-dehydroquinate dehydratase.	1.26721e-148
NC_022604.1\|WP_000569884.1\|899484_899979_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|372596	pfam13420, Acetyltransf_4, Acetyltransferase (GNAT) domain.	2.53639e-47
NC_022604.1\|WP_001802951.1\|898079_898640_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	7.9429e-44
NC_022604.1\|WP_000422909.1\|901746_902286_+\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	1.47647e-49
NC_022604.1\|WP_001033317.1\|911273_912002_-\|staphylococcal-enterotoxin-type-Q	gnl\|CDD\|280949	pfam02876, Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain.	7.79999e-28
NC_022604.1\|WP_000571218.1\|906517_907543_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	3.37873e-170
NC_022604.1\|WP_001018962.1\|905592_905979_+\|topiosmerase	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	2.45102e-36
NC_022604.1\|WP_000264182.1\|909213_910434_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.81902e-37
NC_022604.1\|WP_023180111.1\|907535_908231_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	7.22016e-99
NC_022604.1\|WP_001190695.1\|902435_902756_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.70086e-24
NC_022604.1\|WP_000255561.1\|898712_899330_-\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	9.12336e-62
NC_022604.1\|WP_000589549.1\|902899_903256_+\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NC_022604.1\|WP_000974460.1\|900377_900800_-\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	5.58225e-61
NC_022604.1\|WP_001065801.1\|905971_906268_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	7.01368e-14
NC_022604.1\|WP_001063624.1\|913060_913273_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	7.52525e-13
NC_022604.1\|WP_000142630.1\|912176_912911_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	5.1934e-12
NC_022604.1\|WP_000733773.1\|910521_911250_-\|staphylococcal-enterotoxin-type-K	gnl\|CDD\|280949	pfam02876, Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain.	3.87599e-25

>NC_022604.1|WP_000660172.1|903857_903971_+|hypothetical-protein
MKEKLLGTIIWSIATFYYSRMMEIMNLAILKIKIGGS
>NC_022604.1|WP_000290485.1|903413_903794_+|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVAIIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEISDESQIEALLTAEKYSEMIGE
>NC_022604.1|WP_000589549.1|902899_903256_+|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NC_022604.1|WP_001190695.1|902435_902756_-|thioredoxin-family-protein
MQSIKSNESFKSVINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>NC_022604.1|WP_000422909.1|901746_902286_+|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEGDMPKAPRKNRNLITLY
>NC_022604.1|WP_000150017.1|900947_901664_+|type-I-3-dehydroquinate-dehydratase
MTHVEVVATIAPQLSIEETLIQKINHRIDAIDVLELRIDQIENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFTNDSYLNLISDLANINGIDMIDIEWQADIDIEKHQRIITHLQQYNKEVVISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGVPQAPGQIDVTDLKAQVTLY
>NC_022604.1|WP_000974460.1|900377_900800_-|organic-hydroperoxide-resistance-protein
MAIHYETKATNVGGRKGHVYTDDRALDIDIVPPAQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAHPEVTLTVRLEDDSDSESPKLSVSIDATIKNVISQEEAEKYLQMAHEFCPYSKATQGNINVDLNVNVVD
>NC_022604.1|WP_000569884.1|899484_899979_-|GNAT-family-N-acetyltransferase
MIEIKTLTNNDFNEYKRLVSTVNEEFTQDSHYSQTMTDTLIHDILNQGSPKCIVFGCYENETLIATAALEQIRYVGKEHKSLIKYNFVTNNDKSINSELINFIINYARQNNYESLLTSIVSNNIGAKVFYSALGFDILGFEKNAIKIGNTYFDEHWLFYDLINK
>NC_022604.1|WP_000255561.1|898712_899330_-|amino-acid-transporter
MVTAIIHGFILAIGLILPLGAQNVFIFNQGANQPKYRYVLPAIITAGLSDSLLIIIAVVGVSIIIMSLPVLQAIIYIVGLIFLMYMAWTIWHDKPSTDGETQIMSPMKQVSFALSVSLLNPHAILDTIGVIGSSAALYSGSNKIAFTIACISVSWLWFFLLAILGKMVGSIDKTGKLLTIINKISSIIIIIVALMILQKLIQLLF
>NC_022604.1|WP_001802951.1|898079_898640_+|histidine-phosphatase-family-protein
MRHGQTLFNFKGLIQGFGDSPLTELGIAQAQKARSYYETKGINFDLYASSTQERASDTLENVAPNQSYQRFKGLKEWHFGIFEGESVYLFDNLYKPEDLFGDRIVPFKGEARQQVEERIVKTLHDIMSQTKNNALVVSHGTIMGVFLRYCLKLDEALKHNIGNCNILKFEYDNGTFKFVELIDPNL
>NC_022604.1|WP_001018962.1|905592_905979_+|topiosmerase
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKLDDMIESLYDKQVFVLADSDDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPLLPNINNERLVLVNE
>NC_022604.1|WP_001065801.1|905971_906268_+|thioredoxin-family-protein
MNNSLDIKDVTTFYEEDKHLIFGYTPTCGTCKVSERMLDIANEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFKSVTDLLENLK
>NC_022604.1|WP_000571218.1|906517_907543_+|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEQGPVTQVFENPQHTVTKRFVKDDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
>NC_022604.1|WP_023180111.1|907535_908231_+|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFAFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGTNTWTVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NC_022604.1|WP_000732326.1|908248_909070_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGNKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYELDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGDVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NC_022604.1|WP_000264182.1|909213_910434_-|site-specific-integrase
MWFEKFKNKNKETKYRYYEKYKDPLTNKWRRVSVVLNKNGKQSQKEAQRLLNERIEAKLNDKTPTTLKSLTFHAASDEWFQNYIKTSGSKRTTIKTKLSKLNTLKKFVDEDILINKITLSYAQQVFDEMDSKGYVYQVNKDALSIFKNVFEYTRRIYKLQDLEFLKDITLNKRIKSYDEVKAKRNKYLELNEIQSIIKDINMKAQKMHSGIHKRFYLFVALMTEFQALNGMRIGEMLAIQNEDIDFDNKSLNINGTIHWFHDESGGFGVKDTTKTESSYRTIGLSSRSCEILKKAILENKKDSKWNDGYLNRNFVFTNHKGNPMQTERFNKILREAAKDVGIDKEVSSHILRHSHISLLSQQGVSLKAIMDRVGHSDHRTTLSIYSHVTEQMDKDMMNKLEQVKLG
>NC_022604.1|WP_000733773.1|910521_911250_-|staphylococcal-enterotoxin-type-K
MKKLISILLINIIILGVSNNASAQGDIGIDNLRNFYTKKDFVDLKDVKDNDTPIANQLQFSNESYDLISESKDFNKFSNFKGKKLDVFGISYNGQCNTKYIYGGVTATNEYLDKSRNIPINIWINGNHKTISTNKVSTNKKLVTAQEIDVKLRKYLQEEYNIYGHNGTKKGEEYGHKSKFYSGFNIGKVTFHLNNNDTFSYDLFYTGDDGLPKSFLKIYEDNKTVESEKFHLDVDISYKETI
>NC_022604.1|WP_001033317.1|911273_912002_-|staphylococcal-enterotoxin-type-Q
MNKIFRILTVSLFFFTFLIKNNLAYADVGVINLRNFYANYEPEKLQGVSSGNFSTSHQLEYIDGKYTLYSQFHNEYEAKRLKDHKVDIFGISYSGLCNTKYMYGGITLANQNLDKPRNIPINLWVNGKQNTISTDKVSTQKKEVTAQEIDIKLRKYLQNEYNIYGFNKTKKGQEYGYQSKFNSGFNKGKITFHLNNEPSFTYDLFYTGTGQAESFLKIYNDNKTIDAENFHLDVEISYEKTE
>NC_022604.1|WP_000142630.1|912176_912911_-|helix-turn-helix-transcriptional-regulator
MTFGEILKKERVSWKLSVKELSTLSGVSQTYISKLENGKRNFPSLETIFNLLIGFKTHIEYKMGSESPFYEINNSYLDEILIMFINSSNSTISDRDPNELITQFNEYYDVTIKKKQNENSKIESDIFSNKIKLVKGTTKKEVIEKPYFDLNWLLTQNEYEVFFDRSFLLDNNFLNKKHFTEKDMYYYNVLNDNDLKTIKDLIVVFLLNKYNYIKNKDDFFNIFTNSEDDKTKRDALYKILYETD
>NC_022604.1|WP_001063624.1|913060_913273_+|helix-turn-helix-transcriptional-regulator
MNNNLSLLMGKHRVTASKLSTVTGISRTSIHGLYHERTENPDTKTVMKLCEYFNITPNEFFGIIEKEGVK

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Crispr_ID: NC_022604_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022604_6

1103263-1103350

Orphan

Consensus_repeat	Method
CCCCTAACAACTAAAAGTTGTAAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022604_6

>merge|NC_022604|6|1103263-1103350|CRISPRCasFinder
CCCCTAACAACTAAAAGTTGTAAGGAAGGAGAGGGATACATGCGCCGAGCACATGCATAAAATCCCCTAACAACTAAAAGTTGTAAGG

>NC_022604|6|6|1103263-1103350|CRISPRCasFinder
CCCCTAACAACTAAAAGTTGTAAGG	AAGGAGAGGGATACATGCGCCGAGCACATGCATAAAAT
CCCCTAACAACTAAAAGTTGTAAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022604.1\|WP_000032727.1\|1091717_1093907_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	unknown	unknown	gnl\|CDD\|234921
NC_022604.1\|WP_000030812.1\|1095362_1096391_+\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NC_022604.1\|WP_000514290.1\|1112452_1113115_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NC_022604.1\|WP_000381849.1\|1109942_1111304_+\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NC_022604.1\|WP_000273253.1\|1099986_1100793_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NC_022604.1\|WP_001289614.1\|1109511_1109745_-\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|239274
NC_022604.1\|WP_000238664.1\|1096393_1096960_+\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|223376
NC_022604.1\|WP_000040054.1\|1107556_1109275_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NC_022604.1\|WP_000709290.1\|1096974_1098453_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NC_022604.1\|WP_000437472.1\|1107287_1107554_+\|phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
NC_022604.1\|WP_000064214.1\|1103359_1103494_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000033477.1\|1102200_1102776_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|227065
NC_022604.1\|WP_001632500.1\|1103139_1103259_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000009069.1\|1103645_1104941_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000921968.1\|1100785_1102186_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NC_022604.1\|WP_000505965.1\|1106591_1107134_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368297
NC_022604.1\|WP_000483713.1\|1093885_1095370_+\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235984
NC_022604.1\|WP_000638456.1\|1111300_1112320_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224213
NC_022604.1\|WP_001101908.1\|1098474_1099722_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|237507
NC_022604.1\|WP_000685079.1\|1105365_1106538_+\|class-I-SAM-dependent-rRNA-methyltransferase	unknown	unknown	gnl\|CDD\|224017

Protein	Function_ID	Function_description	E-value
NC_022604.1\|WP_000032727.1\|1091717_1093907_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	gnl\|CDD\|234921	PRK01213, PRK01213, phosphoribosylformylglycinamidine synthase subunit PurL.	0
NC_022604.1\|WP_000030812.1\|1095362_1096391_+\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	0
NC_022604.1\|WP_000514290.1\|1112452_1113115_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	4.35421e-66
NC_022604.1\|WP_000381849.1\|1109942_1111304_+\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	2.48829e-165
NC_022604.1\|WP_000273253.1\|1099986_1100793_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	7.39205e-29
NC_022604.1\|WP_001289614.1\|1109511_1109745_-\|glutaredoxin-family-protein	gnl\|CDD\|239274	cd02976, NrdH, NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase activity that is dependent on TRX reductase, not glutathione (GSH). It is part of the NrdHIEF operon, where NrdEF codes for class Ib ribonucleotide reductase (RNR-Ib), an efficient enzyme at low oxygen levels. Under these conditions when GSH is mostly conjugated to spermidine, NrdH can still function and act as a hydrogen donor for RNR-Ib. It has been suggested that the NrdHEF system may be the oldest RNR reducing system, capable of functioning in a microaerophilic environment, where GSH was not yet available. NrdH from Corynebacterium ammoniagenes can form domain-swapped dimers, although it is unknown if this happens in vivo. Domain-swapped dimerization, which results in the blocking of the TRX reductase binding site, could be a mechanism for regulating the oxidation state of the protein.	5.00495e-16
NC_022604.1\|WP_000238664.1\|1096393_1096960_+\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|223376	COG0299, PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism].	7.23817e-92
NC_022604.1\|WP_000040054.1\|1107556_1109275_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NC_022604.1\|WP_000709290.1\|1096974_1098453_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NC_022604.1\|WP_000638456.1\|1111300_1112320_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|224213	COG1294, AppB, Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion].	6.42118e-76
NC_022604.1\|WP_000437472.1\|1107287_1107554_+\|phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	2.44795e-51
NC_022604.1\|WP_000033477.1\|1102200_1102776_-\|ECF-transporter-S-component	gnl\|CDD\|227065	COG4721, COG4721, ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism].	4.34592e-70
NC_022604.1\|WP_000921968.1\|1100785_1102186_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	1.67975e-64
NC_022604.1\|WP_000483713.1\|1093885_1095370_+\|amidophosphoribosyltransferase	gnl\|CDD\|235984	PRK07272, PRK07272, amidophosphoribosyltransferase; Provisional.	0
NC_022604.1\|WP_000505965.1\|1106591_1107134_+\|hypothetical-protein	gnl\|CDD\|368297	pfam05128, DUF697, Domain of unknown function (DUF697). Family of bacterial hypothetical proteins that is sometimes associated with GTPase domains.	0.00779365
NC_022604.1\|WP_001101908.1\|1098474_1099722_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|237507	PRK13790, PRK13790, phosphoribosylamine--glycine ligase; Provisional.	0
NC_022604.1\|WP_000685079.1\|1105365_1106538_+\|class-I-SAM-dependent-rRNA-methyltransferase	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	5.6543e-145

>NC_022604.1|WP_001632500.1|1103139_1103259_+|hypothetical-protein
MKRDTYQSYLFNNSEEPVHNGLRIIVYKEEEGYMRRAHA
>NC_022604.1|WP_000033477.1|1102200_1102776_-|ECF-transporter-S-component
MSKGLKLSEILVTVLISVVFAVIYNLWWFVYNGVQATGLHLEQLTNGVWFMAAIVCYLIIPKPGIALLAEFAAGAGETIIMGRFDIPTIVYAFIQGLACELVFAIFKYQSRSVMVAMLAGFCTAIAAFPIDYFYGYLNEVAGWNLTLFIVFRLISGAVVAGVLSYLLVKALDKTGVTKLFRPAAKEDYDNL
>NC_022604.1|WP_000921968.1|1100785_1102186_-|ABC-transporter-ATP-binding-protein
MLKVSDLRLKYPSGQRKIFDHLNITIQDKEKVLLLGPSGCGKSTLLNVLSGIVPNLIELPMKYDELIVDPLSGVIFQDPDSQFCMPKVYEELAFVLENRQLPREDMDALIINALNMVNLNVTPETYIKDLSGGMKQKLAIVETILQQSKTLFLDEPTAMLDVQATEDLWTKLIELWEDQTVVIVEHKVKHIWNHVDRVILMDYNGNIIADECPEIILQKYVHLLSEYGVWHPRAWEFAPSRVDFPTTNSHLLQFKNGRIIRGKSTLLSFSDLEIGLGEWITITGANGSGKTTLLESIMQLIKYQGDVYFENQRLTKIKHAAKHMYLVYQNPELQFITNSVYDEINIHFNHLSKDQSDDETIQLLKLLDLQNVKDQHPYELSIGQKRRLSVATALSSKADIIFLDEPTFGLDSHNTFQLIKLFQKRINLGQSIVMVTHDDEIIERYPSRRLKISDGALLDCDGDTNV
>NC_022604.1|WP_000273253.1|1099986_1100793_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MYEQWKVRQSFVDDVNIITKLFLGIILFFFIIFVHNFDFMLYITILMLVFLLMFNGTQFKITAIFITISIGFALLSSLFMILYGNGSHTILKFGFIHITTESLVRGLHVSLRTIAISFFGILIALTSQVVMIFYSLMQHLKVKSKVAYAFMAAIRMIPLMISSLIQLRRSLKMRYQMIDAANYRGLKRFKHLIIPLLSQNIRKAHQLSVAMESKGFRDGPRTYYYNVPFSYKDIIFIIVLIAIITMAYYCSITLPITGIDDVRLGRVG
>NC_022604.1|WP_001101908.1|1098474_1099722_+|phosphoribosylamine--glycine-ligase
MNVLVIGAGGREHALAYKLNQSNLVKQVFVIPGNEAMTPIAEVHTEISESDHQAILDFAKRQNVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMEKYNIPTADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFVNGDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDGPKVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVSGLKKQGDTFVTSGGRVILAIGKGDNVQDAQRDAYKKVSQIQSDHLFYRHDIANKALQLK
>NC_022604.1|WP_000709290.1|1096974_1098453_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MKKAILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGRVKTLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQQTVANPDVTMDEAIENIDIGGPTMLRAAAKNYKHVTTIVHPADYQEVLTRLRNDSLDESYRQSLMIKVFEHTAEYDEAIVRFFKGDKETLRYGENPQQSAYFVRTSNAKHTIAGAKQLHGKQLSYNNIKDADATLALVKKFDTPATVAVKHMNPCGVGIGDTIEQAFQHAYEADSQSIFGGIVALNRAVTPELAEQLHSIFLEVIIAPKFTDEALDILKQKKNVRLLEIDMTIDSNEEEFVSVSGGYLVQDKDNYVVPKEEMKVVTEVAPTDEQWEAMLLGWKVVPSVKSNAIILSNNKQTVGIGAGQMNRVGAAKIALERAIEINDHVALVSDGFFPMGDTVELAAQHGIKAIIQPGGSIKDQDSIDMANKHGIAMVVTGTRHFKH
>NC_022604.1|WP_000238664.1|1096393_1096960_+|phosphoribosylglycinamide-formyltransferase
MVKIAIFASGSGSNFENIVEHVESGKLENIEVTALYTDHQNAFCIDRAKKHDIPVYINEPKQFDSKAAYEQHLVTLLNEDKVEWIILAGYMRLIGPDLLASFEGKILNIHPSLLPKYKGIDAIGQAYHSGDTITGSTVHYVDSGMDTGEIIEQRKCDIRPDDSKEQLEEKVKKLEYELYPSVIAKIVK
>NC_022604.1|WP_000030812.1|1095362_1096391_+|phosphoribosylformylglycinamidine-cyclo-ligase
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSIGIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAVEKDDYVDGSEVKEGQVVIGLASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKAMNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDVSRALKILAEQNVEAYQIGHIVKNESTAIELLGV
>NC_022604.1|WP_000483713.1|1093885_1095370_+|amidophosphoribosyltransferase
MFNYSGLNEECGVFGIWNHPEAAQLTYMGLHSLQHRGQEGAGIVVSDQNELKGERGLGLLTEAIKDDQMERLKGYQHAIGHVRYATSGNKGIENIQPFLYHFYDMSVGICHNGNLINAKSLRQNLEKQGAIFHSSSDTEVIMHLIRRSKAPTFEEALKESLRKVKGGFTFAILTKDALYGAVDPNAIRPLVVGKMKDGTYILASETCAIDVLGAEFVQDIHAGEYVVINDKGITVKSYTHHTTTAISAMEYIYFARPDSTIAGKNVHAVRKASGKKLAQESPVNADMVIGVPNSSLSAASGYAEEIGLPYEMGLVKNQYVARTFIQPTQELREQGVRVKLSAVKDIVDGKNIILVDDSIVRGTTIRRIVKMLKDSGANKVHVRIASPEFMFPSFYGIDVSTTAELISASKSPEEIKDYIGADSLAYLSVDGLIESIGLDYDAPYSGLCVESFTGDYPAGLYDYEANYKAHLSHRQKQYISKNKHFFDSEGNLNV
>NC_022604.1|WP_000032727.1|1091717_1093907_+|phosphoribosylformylglycinamidine-synthase-subunit-PurL
MSKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHSKPFLKQFPTSGDHVLMGPGEGAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSLRFGELDNKQNQRLLKGVVKGIGGYGNCIGIPTTAGEIEFDERYDGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESKRPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQVPTREPGISPYEMMLSETQERMLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLTYDDEVYADIPVEPLADEAPVYILEGEEKDYNTSKNDYTHIDVKDTFFKLLKHPTIASKHYLYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAYRNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNETKGTSIFPTPVVGMVGLIENVNYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHEFESLDLSSEVEKGESIKTAIREGLLSHVQTVGKGGLLITLAKLSAHYGLGLKSSIDITNAQLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGAIAQCLTTQD
>NC_022604.1|WP_000064214.1|1103359_1103494_-|hypothetical-protein
MSNENQNKKAAEKAKEVEEKLKDKKEEKTEDINQTKQDIQDTLN
>NC_022604.1|WP_000009069.1|1103645_1104941_+|hypothetical-protein
MSFLRKHAEIIFSYLIGIVSLFTGLIILINLPLIKQLNGGKKVDTHVHNVWEFLNAFFSEIIKVMSRFIGNFPIVSAIVIIIFGILVMLIGHTLLRTIKYDYDISIFFLVIGIMYFIITLILMTQVYGFFAVIFIIPFTIHIGYIVYKDELNQENVKNHFMWIIVSYGISYLITQIALYGRIDANEIESIDILSVNAFFIIMWLLGQMAIWNFLFLRRALPLTKQELGEEEPELSRTSKGNVTNQTKIHLKQLQDKTTEYARKTRRSVDLDKIRAKRDKFKKKVNDIIDIQEDDIPDWMRKPKWVKPMYVELFCGVVIFLFTFLEFNNRNALFVSGDWKLSQTQYVIEWVTLLILLFIIIAYIATTLTFHLKGKFYYLQLFMGSILFFKLLTEFINIMIHGLLLSVFITPTLLLMLLAIIISYSLQLRERP
>NC_022604.1|WP_000685079.1|1105365_1106538_+|class-I-SAM-dependent-rRNA-methyltransferase
MKIATLNKGKETKYFNGYPLIEEEDIYSQDHLKEGDIFQIVTDKSQYVATAYVGRQHKGLGWVLTYDKAQQINTAFFVKLFNTALAERDYYFNIDGTNAFRLFNAEGDGVGGLTIDNYDGHLLIQWYSKGIYKFKYAILEAVRKVFDYKSIYEKVRFKDSEYSGGFVEGDAPEFPIVIEENFTFYNVDLEDGLMTGIFLDQKEVRKKLRDQYAKERHVLNLFSYTGAFSAIAASEASSTTSVDLANRSRSLTEENFGLNAIDPKSQYIYVMDTFDFYKYAARHGHSYDTIVIDPPSFARNKKRTFSVQKDYDKLINGALNILSSEGTLLLCTNASVYPLKQFKNTIKKTLEESGVDYELTEVMGLPKDFKTHPHYKPSKYLKAVFVNIRH
>NC_022604.1|WP_000505965.1|1106591_1107134_+|hypothetical-protein
MGFKNNLTSNLTNKIGNSVFKIENVDGKGAMPTTIQELRERRQRAEAIVKRKSLMSSTMSVVPIPGLDFGVDLKLMKDIIEDVNKIYGLDHKQVNSLGDDVKERIMSAAAIQGSQFIGKRISNAFLKIVIRDVAKRTAAKQTKWFPVVGQAVSASISYYFMNKIGKDHIQKCENVIKNVM
>NC_022604.1|WP_000437472.1|1107287_1107554_+|phosphocarrier-protein-HPr
MEQNSYVIIDETGIHARPATMLVQTASKFDSDIQLEYNGKKVNLKSIMGVMSLGVGKDAEITIYADGSDESDAIQAISDVLSKEGLTK
>NC_022604.1|WP_000040054.1|1107556_1109275_+|phosphoenolpyruvate--protein-phosphotransferase
MSKLIKGIAASDGVAIAKAYLLVEPDLTFDKNEKVTDVEGEVAKFNSAIEASKVELTKIRNNAEVQLGADKAAIFDAHLLVLDDPELIQPIQDKIKNENANAATALTDVTTQFVTIFESMDNEYMKERAADIRDVSKRVLSHILGVELPNPSMIDESVVIVGNDLTPSDTAQLNKEFVQGFATNIGGRTSHSAIMSRSLEIPAIVGTKSITQEVKQGDMIIVDGLNGDVIVNPTEDELIAYQDKRERYFADKKELQKLRDADTVTVDGVHAELAANIGTPNDLPGVIENGAQGIGLYRTEFLYMGRDQMPTEEEQFEAYKEVLEAMGGKRVVVRTLDIGGDKELSYLNLPEEMNPFLGYRAIRLCLAQQDIFRPQLRALLRASVYGKLNIMFPMVATINEFREAKAILLEEKENLKNEGHDISDDIELGIMVEIPATAALADVFAKEVDFFSIGTNDLIQYTLAADRMSERVSYLYQPYNPSILRLVKQVIEASHKEGKWTGMCGEMAGDETAIPLLLGLGLDEFSMSATSILKARRQINGLSKNEMTELANRAVDCATQEEVIELVNNYVK
>NC_022604.1|WP_001289614.1|1109511_1109745_-|glutaredoxin-family-protein
MSEIIVYTQNDCPPCTFVKNYLNEHHIDFEERNINNQQYRNEMIDFDAFSTPFILLNGNPMYHVDLDEINKVLNIQD
>NC_022604.1|WP_000381849.1|1109942_1111304_+|cytochrome-ubiquinol-oxidase-subunit-I
MDTVEISRFLTAMTLAVHIIFATIGVGMPLMFAIAEFLGIRKNDLQYIAMAKRWAKAYTITVAVGVVTGTIIGLQLSLIWPTFMEMGGHVIALPLFMETFAFFFEAIFLSIYLYTWDRFKNKWTHFLISIPVIIGGSFSAFFITSVNSFMNTPAGFELKNGKMVNVQPIEAMFNPSFIVRSFHVITTAGMTMAFVIASIAAFKLLRNRQPKDTVYHKKALKMSMIVGFFSTLLSMLAGDLSAKFLHKFQPEKLAAYEWHFDTSSHAKLLLFGVLDEKTQQVKGAIELPGLLSFLADNSVKTKVQGLNDFPKSLHPPMIVHYFFDLMVTMGILCFVISGVYVLTLMFKKLRKFSTHKWMLYGILLTGPASMLAIEFGWFLTEMGRQPWIVRGYMRVAEAATQAGGITFVTILFGILYIILMYTCAYVLIRMFKNKPAYEDVNRLAKKQGGEIEK
>NC_022604.1|WP_000638456.1|1111300_1112320_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MIYAFIGITVLWLFLFCYIIIASIDFGAGFFALHSKLTGDEKKINHLISRYLNPVWEVTNVFFVFFFVGFVGFFPESIKYLGTVLLIPGSIALIMISLRNSFYAFENYGQDTKLAWMIMYGVSGLLIPASLSTALTITEGGYINVRNNVIDLDWVQLLLSPFAWSVVFLAIISVLYISSGFLTYYAKKANDEPAYNLTRQWHIFLGPPMIIICLFVFLSLRIQNSEHFYSAVFDYWWMFGISFLFFALASLLTFFKKKHGLAFVFVILQMMFAFFGYGISKLPYLLYPFVKITDAYVNPEMGWTLVIVFILGLLLLLPSLILLLRLFVFDKEYVEGKKS
>NC_022604.1|WP_000514290.1|1112452_1113115_+|TrkA-family-potassium-uptake-protein
MGKEYVVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYSDIATHAVVADTTDEAVMKSLGIRNFDHVIVAIGENIQSSTLTTLILKELGVKKVTAKAQNDYHAKILNKIGADTVVHPERDMGRRIAHNVASASVLDYLELADEHSIVELKATEKMAGQSIIDLDIRAQYGINIIAIKRGKEFIISPNPNINLEIGDILIMIGHDNDLNRFEKNIATR

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Crispr_ID: NC_022604_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022604_7

1225391-1225692

Orphan

Consensus_repeat	Method
TGCAAGTTGGNGNGGNNCCNA	CRT
TCAGCATACAAAAATGTGCAAGTTGGCGGGGCCCCAACATAGAGAAATAGGA	PILER-CR

5 spacers

The CRISPR arrays of NC_022604_7

>merge|NC_022604|7|1225391-1225692|CRT,PILER-CR
TGCAAGTTGGCGGGGCCCCAACAGAGAGAAATAGGATCACCAATTTCAACAGACAATGCAAGTTGGGGTGGGGCCCAACACAGAAGCTGGCGAAAAGTCAGCATACAAAAATGTGCAAGTTGGCGGGGCCCCAACAGAGAGAAATAGGATCACCAATTCCAACAAACAATGCAAGTTGGCGGGGCCCCAATATAGAAGCTGGCGAAAAGTCAGCATACAAAAATGTGCAAGTTGGCGGGGCCCCAACATAGAGAAATTGGAACCCCAATTTCTACAGACAATGCAAGTTGGGGTAGGACATC

>NC_022604|7|1|1225391-1225692|CRT
TGCAAGTTGGCGGGGCCCCAA	CAGAGAGAAATAGGATCACCAATTTCAACAGACAA
TGCAAGTTGGGGTGGGGCCCA	ACACAGAAGCTGGCGAAAAGTCAGCATACAAAAATG
TGCAAGTTGGCGGGGCCCCAA	CAGAGAGAAATAGGATCACCAATTCCAACAAACAA
TGCAAGTTGGCGGGGCCCCAA	TATAGAAGCTGGCGAAAAGTCAGCATACAAAAATG
TGCAAGTTGGCGGGGCCCCAA	CATAGAGAAATTGGAACCCCAATTTCTACAGACAA
TGCAAGTTGGGGTAGGACATC

>NC_022604|7|1|1225488-1225651|PILER-CR
TCAGCATACAAAAATGTGCAAGTTGGCGGGGCCCCAACAGAGAGAAATAGGA	TCACCAATTCCAACAAACAA
TGCAAGTTGGCGGGGCCCCAATATAGAAGCTGGCGAAAAGTCAGCATACAAA	AATGTGCAAGTTG
GCGGGGCCCCAACATAGAGAAATTGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022604.1\|WP_000791587.1\|1224025_1224523_+\|complement-convertase-inhibitor-Efb	unknown	unknown	gnl\|CDD\|289007
NC_022604.1\|WP_000765708.1\|1230328_1230475_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000739563.1\|1222188_1222590_-\|formyl-peptide-receptor-like-1-inhibitory-protein	unknown	unknown	gnl\|CDD\|171849
NC_022604.1\|WP_000848124.1\|1227364_1228324_-\|beta-channel-forming-cytolysin	unknown	unknown	gnl\|CDD\|273388
NC_022604.1\|WP_000669537.1\|1224676_1225027_+\|complement-inhibitor-SCIN-B	unknown	unknown	gnl\|CDD\|371594
NC_022604.1\|WP_000041896.1\|1231156_1231873_-\|superantigen-like-protein-SSL12	unknown	unknown	gnl\|CDD\|171995
NC_022604.1\|WP_000195429.1\|1228588_1229761_+\|IS256-like-element-IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NC_022604.1\|WP_000739209.1\|1221490_1221820_+\|complement-convertase-inhibitor-Ecb	unknown	unknown	gnl\|CDD\|289007
NC_022604.1\|WP_000739523.1\|1232800_1233526_-\|superantigen-like-protein-SSL14	unknown	unknown	gnl\|CDD\|171855
NC_022604.1\|WP_000584398.1\|1223260_1223767_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_001032814.1\|1225847_1226033_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_001039659.1\|1219106_1219907_+\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851
NC_022604.1\|WP_000793606.1\|1233963_1234965_+\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|235269
NC_022604.1\|WP_001802045.1\|1230431_1230656_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_001063557.1\|1231980_1232706_-\|superantigen-like-protein-SSL13	unknown	unknown	gnl\|CDD\|106307
NC_022604.1\|WP_000231632.1\|1226654_1226888_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_001803346.1\|1221129_1221297_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000049484.1\|1220498_1221002_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|223695
NC_022604.1\|WP_000659317.1\|1219918_1220506_+\|XTP/dITP-diphosphatase	unknown	unknown	gnl\|CDD\|184835
NC_022604.1\|WP_001791789.1\|1222136_1222229_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022604.1\|WP_000791587.1\|1224025_1224523_+\|complement-convertase-inhibitor-Efb	gnl\|CDD\|289007	pfam12199, efb-c, Extracellular fibrinogen binding protein C terminal. This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.	5.40265e-27
NC_022604.1\|WP_000739563.1\|1222188_1222590_-\|formyl-peptide-receptor-like-1-inhibitory-protein	gnl\|CDD\|171849	PRK13033, PRK13033, formyl peptide receptor-like 1 inhibitory protein; Reviewed.	3.87075e-77
NC_022604.1\|WP_000669537.1\|1224676_1225027_+\|complement-inhibitor-SCIN-B	gnl\|CDD\|371594	pfam11546, CompInhib_SCIN, Staphylococcal complement inhibitor SCIN. SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface. An 18 residue stretch 31-48 is crucial for SCIN activity.	2.0882e-48
NC_022604.1\|WP_000195429.1\|1228588_1229761_+\|IS256-like-element-IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	0
NC_022604.1\|WP_000739209.1\|1221490_1221820_+\|complement-convertase-inhibitor-Ecb	gnl\|CDD\|289007	pfam12199, efb-c, Extracellular fibrinogen binding protein C terminal. This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.	4.63429e-22
NC_022604.1\|WP_001039659.1\|1219106_1219907_+\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	2.38427e-134
NC_022604.1\|WP_000041896.1\|1231156_1231873_-\|superantigen-like-protein-SSL12	gnl\|CDD\|171995	PRK13350, PRK13350, superantigen-like protein; Reviewed.	1.29441e-152
NC_022604.1\|WP_000739523.1\|1232800_1233526_-\|superantigen-like-protein-SSL14	gnl\|CDD\|171855	PRK13043, PRK13043, superantigen-like protein; Reviewed.	8.18566e-161
NC_022604.1\|WP_001063557.1\|1231980_1232706_-\|superantigen-like-protein-SSL13	gnl\|CDD\|106307	PRK13349, PRK13349, superantigen-like protein; Reviewed.	4.11802e-148
NC_022604.1\|WP_000848124.1\|1227364_1228324_-\|beta-channel-forming-cytolysin	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	1.62736e-140
NC_022604.1\|WP_000049484.1\|1220498_1221002_+\|metallophosphoesterase	gnl\|CDD\|223695	COG0622, COG0622, Predicted phosphoesterase [General function prediction only].	9.91823e-44
NC_022604.1\|WP_000659317.1\|1219918_1220506_+\|XTP/dITP-diphosphatase	gnl\|CDD\|184835	PRK14822, PRK14822, XTP/dITP diphosphatase.	1.88157e-114
NC_022604.1\|WP_000793606.1\|1233963_1234965_+\|ornithine-carbamoyltransferase	gnl\|CDD\|235269	PRK04284, PRK04284, ornithine carbamoyltransferase; Provisional.	0

>NC_022604.1|WP_000669537.1|1224676_1225027_+|complement-inhibitor-SCIN-B
MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSNVYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
>NC_022604.1|WP_000791587.1|1224025_1224523_+|complement-convertase-inhibitor-Efb
MKNKLIAKSLLTLAAIGITTTTIASTADASEGYGPREKKPVSINHNIVEYNDGTFKYQSRPKFNSTPKYIKFKHDYNILEFNDGTFEYGARPQFNKPAAKTDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVK
>NC_022604.1|WP_000584398.1|1223260_1223767_+|hypothetical-protein
MIIKILTILLLLCILSYLVTNRKKPFLFLKTLFMGVVFIFIGYISLAISAVIIYGIIQFITIDFGSFFLMGIILILISSIFQLFIVRLLFRKKNVDLTEVVVLEHLIQWFLVYFAIYQAVNEKMDINDINIDNFQSVFFDVSNLNLVILPTLIISWVTIFNYRMRSYK
>NC_022604.1|WP_000739563.1|1222188_1222590_-|formyl-peptide-receptor-like-1-inhibitory-protein
MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKESDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIKVVKNGEIDSITWY
>NC_022604.1|WP_001791789.1|1222136_1222229_-|hypothetical-protein
MLKTVKSTRLLGIKKHTELNSCTPNVRKQC
>NC_022604.1|WP_000739209.1|1221490_1221820_+|complement-convertase-inhibitor-Ecb
MKKNFIGKSILSIAAISLTVSTFAGESHAQTKNVEAAKKYDQYQTNFKKQVNKKVVDAQKAVNFFKRTRTVATHRKAQRAVNLIHFQHSYEKKKLQRQIDLVLKYNTLK
>NC_022604.1|WP_001803346.1|1221129_1221297_+|hypothetical-protein
MKRIVILENVIVDNPIWLNHVDYLVKSVLLKSIKLRFQEVKKFEILVKIMNRIHI
>NC_022604.1|WP_000049484.1|1220498_1221002_+|metallophosphoesterase
MSKWIIVSDNHTESGVLYQIYEMHPDADVYLHLGDSEFAYDDTELSLFNRVKGNCDFYPEFENEAVAKYNDVKAFYTHGHLYQVNRTRDLLAEKGLELGCLFAFYGHTHVAKYEYINGVHVINPGSISQSRSSMEETYAEVIIDDQTLHGTINFKNRHHETISHTTF
>NC_022604.1|WP_000659317.1|1219918_1220506_+|XTP/dITP-diphosphatase
MKEIVIASNNQGKINDFKVIFPDYHVIGISELIPDFDVEETGSTFEENAILKSEAAAKALNKTVIADDSGLEVFALNGEPGIYSARYAGENKSDEANIEKLLNKLGNTTDRRAQFVCVISMSGPDMETKVFKGTVSGEIADGKYGENGFGYDPIFYVPKLDKTMAQLSKEQKGQISHRRNAINLLQAFLEGDKNV
>NC_022604.1|WP_001039659.1|1219106_1219907_+|glutamate-racemase
MNKPIGVIDSGVGGLTVAKEIMRQLPNETIYYLGDIGRCPYGPRPGEQVKQYTVEIARKLMEFDIKMLVIACNTATAVALEYLQKTLSIPVIGVIEPGARTAIMTTRNQNVLVLGTEGTIKSEAYRTHIKRINPHVEVHGVACPGFVPLVEQMRYSDPTITSIVIHQTLKRWRNSESDTVILGCTHYPLLYKPIYDYFGGKKTVISSGLETAREVSALLTFSNEHASYTEHPDHRFFATGDPTHITNIIKEWLNLSVNVERISVND
>NC_022604.1|WP_001032814.1|1225847_1226033_-|hypothetical-protein
MNKHINKKAAKLLEDYKKVQQRKSKETDRGCLKSVIMLIVLFFLIIFGIVACSTNVNFFFQ
>NC_022604.1|WP_000231632.1|1226654_1226888_-|hypothetical-protein
MVFNDWEINVVYSGEHEVVTNEKSLFVIDEFYDVAIAIYYLDGKLKVAHVNYGSDFTIDVANKVFELNIQNPNVDEH
>NC_022604.1|WP_000848124.1|1227364_1228324_-|beta-channel-forming-cytolysin
MKTHIVSSVTTTLLLGSILMNPVANAADSDINIKTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWIDRSSERYKIDWEKEEMTN
>NC_022604.1|WP_000195429.1|1228588_1229761_+|IS256-like-element-IS256-family-transposase
MTQVHFTLKSEEIQSIIEYSVKDDVSKNILTTVFNQLMENQRTEYIQAKEYERTENRQSQRNGYYERSFTTRVGTLELKVPRTRDGHFSPTVFERYQRNEKALMASMLEMYVSGVSTRKVSKIVEELCGKSVSKSFVSSLTEQLEPMVNEWQNRLLSEKNYPYLMTDVLYIKVREENRVLSKSCHIAIGITKDGDREIIGFMIQSGESEETWTTFFEYLKERGLQGTELVISDAHKGLVSAIRKSFTNVSWQRCQVHFLRNIFTTIPKKNSKSFREAVKGIFKFTDINLAREAKNRLIHDYIDQPKYSKACASLDDGFEDAFQYTVQGNSHNRLKSTNLIERLNQEVRRREKIIRIFPNQTSANRLIGAVLMDLHDEWIYSSRKYINFDK
>NC_022604.1|WP_000765708.1|1230328_1230475_+|hypothetical-protein
MKLFYIVFLIIIWLNIFLGNEIIHTLTVLITTLYIVNSRKGIKNDRVE
>NC_022604.1|WP_001802045.1|1230431_1230656_+|hypothetical-protein
MLIQERGLKMTELNNIINSLQSLFESESGYKISKNSGVPYQTVQDLRNGKTKLEDARFRTIIKLYSYYVSLKEH
>NC_022604.1|WP_000041896.1|1231156_1231873_-|superantigen-like-protein-SSL12
MSKNITKNIILTTTLLLLGTVLPQNQKPVFSFYSEAKAYSIGQDETNINELIKYYTQPHFSFSNKWLYQYDNGNIYVELKRYSWSAHISLWGAESWGNINQLKDRYVDVFGLKDKDTDQLWWSYRETFTGGVTPAAKPSDKTYNLFVQYKDKLQTIIGAHKIYQGNKPVLTLKEIDFRAREALIKNKILYNENRNKGKLKITGGGNNYTIDLSKRLHSDLANVYVKNPNKITVDVLFD
>NC_022604.1|WP_001063557.1|1231980_1232706_-|superantigen-like-protein-SSL13
MNNNITKKIILSTTLLLLGTASTQFPNTPINSSSEAKAHYINQNETNVNELTKYYSQKYLTFSNSTLWQKDNGTIHATLLQFSWYSHIQVYGPESWGNINQLRNKSVDIFGIKDQETIDSFALSQETFTGGVTPAATSNDKHYKLNVTYKDKAETFTGGFPVYEGNKPVLTLKELDFRIRQTLIKSKKLYNNSYNKGQIKITGADNNYTIDLSKRLPSTDANRYVKKPQNAKIEVILEKSN
>NC_022604.1|WP_000739523.1|1232800_1233526_-|superantigen-like-protein-SSL14
MKKNIMNKLVLSTALLLLETTSTQLPKTPISFSSEAKAYNISENETNINELIKYYTQPHFSLSGKWLWQKPNGSIHATLQTWVWYSHIQVFGSESWGNINQLRNKYVDIFGTKDEDTVEGYWTYDETFTGGVTPAATSSDKPYRLFLKYSDKQQTIIGGHEFYKGNKPVLTLKELDFRIRQTLIKNKKLYNGEFNKGQIKITADGNNYTIDLSKKLKLTDTNRYVKNPRNAEIEVILEKSN
>NC_022604.1|WP_000793606.1|1233963_1234965_+|ornithine-carbamoyltransferase
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTRCAFEVAAHDQGANVTYLGPTGSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTYVGDGRNNVANALMQGAAIMGMNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPDEVWKERLELLKPYQVNKEIMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVTDEVLESKASVVFQEAENRMHTIKAVMVATLGEF

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Click the colored protein region to show detailed information

Crispr_ID: NC_022604_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022604_8

1230896-1230981

Orphan

Consensus_repeat	Method
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022604_8

>merge|NC_022604|8|1230896-1230981|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGGCGGGGCCCCAACATAGAAGCTGGCGGAAAGTCAGCTTACAATAATGTGCAAGTTGG

>NC_022604|8|7|1230896-1230981|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CGGGGCCCCAACATAGAAGCTGGCGG
AAAGTCAGCTTACAATAATGTGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022604.1\|WP_000791587.1\|1224025_1224523_+\|complement-convertase-inhibitor-Efb	unknown	unknown	gnl\|CDD\|289007
NC_022604.1\|WP_000765708.1\|1230328_1230475_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000739563.1\|1222188_1222590_-\|formyl-peptide-receptor-like-1-inhibitory-protein	unknown	unknown	gnl\|CDD\|171849
NC_022604.1\|WP_000398672.1\|1240783_1240918_+\|beta-class-phenol-soluble-modulin	unknown	unknown	gnl\|CDD\|368464
NC_022604.1\|WP_000669537.1\|1224676_1225027_+\|complement-inhibitor-SCIN-B	unknown	unknown	gnl\|CDD\|371594
NC_022604.1\|WP_000041896.1\|1231156_1231873_-\|superantigen-like-protein-SSL12	unknown	unknown	gnl\|CDD\|171995
NC_022604.1\|WP_000195429.1\|1228588_1229761_+\|IS256-like-element-IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NC_022604.1\|WP_000149423.1\|1237955_1238183_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000739523.1\|1232800_1233526_-\|superantigen-like-protein-SSL14	unknown	unknown	gnl\|CDD\|171855
NC_022604.1\|WP_000600047.1\|1236157_1237648_+\|YfcC-family-protein	unknown	unknown	gnl\|CDD\|224207
NC_022604.1\|WP_001245802.1\|1239683_1239872_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225382
NC_022604.1\|WP_001032814.1\|1225847_1226033_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_001802045.1\|1230431_1230656_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_001063557.1\|1231980_1232706_-\|superantigen-like-protein-SSL13	unknown	unknown	gnl\|CDD\|106307
NC_022604.1\|WP_001239288.1\|1238487_1239435_-\|TDT-family-transporter	unknown	unknown	gnl\|CDD\|187765
NC_022604.1\|WP_000231632.1\|1226654_1226888_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000848124.1\|1227364_1228324_-\|beta-channel-forming-cytolysin	unknown	unknown	gnl\|CDD\|273388
NC_022604.1\|WP_000584398.1\|1223260_1223767_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000793606.1\|1233963_1234965_+\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|235269
NC_022604.1\|WP_001074342.1\|1234987_1235920_+\|carbamate-kinase	unknown	unknown	gnl\|CDD\|237071

Protein	Function_ID	Function_description	E-value
NC_022604.1\|WP_000791587.1\|1224025_1224523_+\|complement-convertase-inhibitor-Efb	gnl\|CDD\|289007	pfam12199, efb-c, Extracellular fibrinogen binding protein C terminal. This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.	5.40265e-27
NC_022604.1\|WP_000739563.1\|1222188_1222590_-\|formyl-peptide-receptor-like-1-inhibitory-protein	gnl\|CDD\|171849	PRK13033, PRK13033, formyl peptide receptor-like 1 inhibitory protein; Reviewed.	3.87075e-77
NC_022604.1\|WP_000669537.1\|1224676_1225027_+\|complement-inhibitor-SCIN-B	gnl\|CDD\|371594	pfam11546, CompInhib_SCIN, Staphylococcal complement inhibitor SCIN. SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface. An 18 residue stretch 31-48 is crucial for SCIN activity.	2.0882e-48
NC_022604.1\|WP_000398672.1\|1240783_1240918_+\|beta-class-phenol-soluble-modulin	gnl\|CDD\|368464	pfam05480, Staph_haemo, Staphylococcus haemolytic protein. This family consists of several different short Staphylococcal proteins, it contains SLUSH A, B and C proteins as well as haemolysin and gonococcal growth inhibitor. Some strains of the coagulase-negative Staphylococcus lugdunensis produce a synergistic hemolytic activity (SLUSH), phenotypically similar to the delta-hemolysin of S. aureus. Gonococcal growth inhibitor from Staphylococcus act on the cytoplasmic membrane of the gonococcal cell causing cytoplasmic leakage and, eventually, death.	6.35158e-13
NC_022604.1\|WP_000195429.1\|1228588_1229761_+\|IS256-like-element-IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	0
NC_022604.1\|WP_000739523.1\|1232800_1233526_-\|superantigen-like-protein-SSL14	gnl\|CDD\|171855	PRK13043, PRK13043, superantigen-like protein; Reviewed.	8.18566e-161
NC_022604.1\|WP_000600047.1\|1236157_1237648_+\|YfcC-family-protein	gnl\|CDD\|224207	COG1288, COG1288, Predicted membrane protein [Function unknown].	0
NC_022604.1\|WP_001245802.1\|1239683_1239872_+\|hypothetical-protein	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	0.00787195
NC_022604.1\|WP_000041896.1\|1231156_1231873_-\|superantigen-like-protein-SSL12	gnl\|CDD\|171995	PRK13350, PRK13350, superantigen-like protein; Reviewed.	1.29441e-152
NC_022604.1\|WP_001239288.1\|1238487_1239435_-\|TDT-family-transporter	gnl\|CDD\|187765	cd09325, TDT_C4-dicarb_trans, C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.	1.39126e-83
NC_022604.1\|WP_001063557.1\|1231980_1232706_-\|superantigen-like-protein-SSL13	gnl\|CDD\|106307	PRK13349, PRK13349, superantigen-like protein; Reviewed.	4.11802e-148
NC_022604.1\|WP_000848124.1\|1227364_1228324_-\|beta-channel-forming-cytolysin	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	1.62736e-140
NC_022604.1\|WP_000793606.1\|1233963_1234965_+\|ornithine-carbamoyltransferase	gnl\|CDD\|235269	PRK04284, PRK04284, ornithine carbamoyltransferase; Provisional.	0
NC_022604.1\|WP_001074342.1\|1234987_1235920_+\|carbamate-kinase	gnl\|CDD\|237071	PRK12353, PRK12353, putative amino acid kinase; Reviewed.	0

>NC_022604.1|WP_001802045.1|1230431_1230656_+|hypothetical-protein
MLIQERGLKMTELNNIINSLQSLFESESGYKISKNSGVPYQTVQDLRNGKTKLEDARFRTIIKLYSYYVSLKEH
>NC_022604.1|WP_000765708.1|1230328_1230475_+|hypothetical-protein
MKLFYIVFLIIIWLNIFLGNEIIHTLTVLITTLYIVNSRKGIKNDRVE
>NC_022604.1|WP_000195429.1|1228588_1229761_+|IS256-like-element-IS256-family-transposase
MTQVHFTLKSEEIQSIIEYSVKDDVSKNILTTVFNQLMENQRTEYIQAKEYERTENRQSQRNGYYERSFTTRVGTLELKVPRTRDGHFSPTVFERYQRNEKALMASMLEMYVSGVSTRKVSKIVEELCGKSVSKSFVSSLTEQLEPMVNEWQNRLLSEKNYPYLMTDVLYIKVREENRVLSKSCHIAIGITKDGDREIIGFMIQSGESEETWTTFFEYLKERGLQGTELVISDAHKGLVSAIRKSFTNVSWQRCQVHFLRNIFTTIPKKNSKSFREAVKGIFKFTDINLAREAKNRLIHDYIDQPKYSKACASLDDGFEDAFQYTVQGNSHNRLKSTNLIERLNQEVRRREKIIRIFPNQTSANRLIGAVLMDLHDEWIYSSRKYINFDK
>NC_022604.1|WP_000848124.1|1227364_1228324_-|beta-channel-forming-cytolysin
MKTHIVSSVTTTLLLGSILMNPVANAADSDINIKTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWIDRSSERYKIDWEKEEMTN
>NC_022604.1|WP_000231632.1|1226654_1226888_-|hypothetical-protein
MVFNDWEINVVYSGEHEVVTNEKSLFVIDEFYDVAIAIYYLDGKLKVAHVNYGSDFTIDVANKVFELNIQNPNVDEH
>NC_022604.1|WP_001032814.1|1225847_1226033_-|hypothetical-protein
MNKHINKKAAKLLEDYKKVQQRKSKETDRGCLKSVIMLIVLFFLIIFGIVACSTNVNFFFQ
>NC_022604.1|WP_000669537.1|1224676_1225027_+|complement-inhibitor-SCIN-B
MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSNVYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
>NC_022604.1|WP_000791587.1|1224025_1224523_+|complement-convertase-inhibitor-Efb
MKNKLIAKSLLTLAAIGITTTTIASTADASEGYGPREKKPVSINHNIVEYNDGTFKYQSRPKFNSTPKYIKFKHDYNILEFNDGTFEYGARPQFNKPAAKTDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVK
>NC_022604.1|WP_000584398.1|1223260_1223767_+|hypothetical-protein
MIIKILTILLLLCILSYLVTNRKKPFLFLKTLFMGVVFIFIGYISLAISAVIIYGIIQFITIDFGSFFLMGIILILISSIFQLFIVRLLFRKKNVDLTEVVVLEHLIQWFLVYFAIYQAVNEKMDINDINIDNFQSVFFDVSNLNLVILPTLIISWVTIFNYRMRSYK
>NC_022604.1|WP_000739563.1|1222188_1222590_-|formyl-peptide-receptor-like-1-inhibitory-protein
MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKESDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIKVVKNGEIDSITWY
>NC_022604.1|WP_000041896.1|1231156_1231873_-|superantigen-like-protein-SSL12
MSKNITKNIILTTTLLLLGTVLPQNQKPVFSFYSEAKAYSIGQDETNINELIKYYTQPHFSFSNKWLYQYDNGNIYVELKRYSWSAHISLWGAESWGNINQLKDRYVDVFGLKDKDTDQLWWSYRETFTGGVTPAAKPSDKTYNLFVQYKDKLQTIIGAHKIYQGNKPVLTLKEIDFRAREALIKNKILYNENRNKGKLKITGGGNNYTIDLSKRLHSDLANVYVKNPNKITVDVLFD
>NC_022604.1|WP_001063557.1|1231980_1232706_-|superantigen-like-protein-SSL13
MNNNITKKIILSTTLLLLGTASTQFPNTPINSSSEAKAHYINQNETNVNELTKYYSQKYLTFSNSTLWQKDNGTIHATLLQFSWYSHIQVYGPESWGNINQLRNKSVDIFGIKDQETIDSFALSQETFTGGVTPAATSNDKHYKLNVTYKDKAETFTGGFPVYEGNKPVLTLKELDFRIRQTLIKSKKLYNNSYNKGQIKITGADNNYTIDLSKRLPSTDANRYVKKPQNAKIEVILEKSN
>NC_022604.1|WP_000739523.1|1232800_1233526_-|superantigen-like-protein-SSL14
MKKNIMNKLVLSTALLLLETTSTQLPKTPISFSSEAKAYNISENETNINELIKYYTQPHFSLSGKWLWQKPNGSIHATLQTWVWYSHIQVFGSESWGNINQLRNKYVDIFGTKDEDTVEGYWTYDETFTGGVTPAATSSDKPYRLFLKYSDKQQTIIGGHEFYKGNKPVLTLKELDFRIRQTLIKNKKLYNGEFNKGQIKITADGNNYTIDLSKKLKLTDTNRYVKNPRNAEIEVILEKSN
>NC_022604.1|WP_000793606.1|1233963_1234965_+|ornithine-carbamoyltransferase
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTRCAFEVAAHDQGANVTYLGPTGSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTYVGDGRNNVANALMQGAAIMGMNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPDEVWKERLELLKPYQVNKEIMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVTDEVLESKASVVFQEAENRMHTIKAVMVATLGEF
>NC_022604.1|WP_001074342.1|1234987_1235920_+|carbamate-kinase
MAKIVVALGGNALGKSPQEQLELVKNTAKSLVGLITKGHEIVISHGNGPQVGSINLGLNYAAEHNQGPAFPFAECGAMSQAYIGYQLQESLQNELHSIGMDKQVVTLVTQVEVDENDPAFNNPSKPIGLFYNKEEAEQIQKEKGFIFVEDAGRGYRRVVPSPQPISIIELESIKTLIKNDTLVIAAGGGGIPVIREQHDGFKGIDAVIDKDKTSALLGANIQCDQLIILTAIDYVYINFNTENQQPLKTTNVDELKRYIDENQFAKGSMLPKIEAAISFIENNPKGSVLITSLNELDAALEGKVGTVIKK
>NC_022604.1|WP_000600047.1|1236157_1237648_+|YfcC-family-protein
MILFILTVVAVIATWVIPAGAYSKLSYEPSSQELKIVNPHNQVKKVPGTQQELDKMGVKIKIEQFKSGAINKPVSIPNTYERLKQHPAGPEQITSSMVEGTIEAVDIMVFILVLGGLIGVVQASGSFESGLLALTKKTKGHEFMLIVFVSILMIIGGTLCGIEEEAVAFYPILVPIFIALGYDSIVSVGAIFLASSVGSTFSTINPFSVVIASNAAGTTFTDGLYWRIGACIVGAIFVISYLYWYCKKIKNDPKASYSYEDKDAFEQQWSVLKDDDSAHFTLRKKIILTLFVLPFPIMVWGVMTQGWWFPVMASAFLIFTIIIMFIAGTGKSGLGEKGTVDAFVNGASSLVGVSLIIGLARGINLVLNEGMISDTILHFSSSLVQHMSGPLFIIVLLFIFFCLGFIVPSSSGLAVLSMPIFAPLADTVGIPRFVIVTTYQFGQYAMLFLAPTGLVMATLQMLNMRYSHWFRFVWPVVAFVLIFGGGVLITQVLIYS
>NC_022604.1|WP_000149423.1|1237955_1238183_+|hypothetical-protein
MTHLTKVLDTLTGICVVLLFSKYFVAYANMVFDWNLRWYLLENIPHLPIILFILMFIFGVPSEMIKDRQRKNNGV
>NC_022604.1|WP_001239288.1|1238487_1239435_-|TDT-family-transporter
MRLQKAPLVTSGLVLGLLGLGNLLKDLSLTLNAVCGIFAFLIWIHLLCTMIKYFNNVKEQLNSPLVSSVFTTFFMSGFLGTTYLNTFFSNITFINSLITPIWILCLVGIMTHMIIFSIKYLKDFSLKNVYPSWTVLFIGIAIAGLTAPVSGYFFIGQLTVIYGFVATCIVLPIVFKRLKAFPLQTSIKPNTSTICAPFSLVAAAYVIAFPKANAFIVIIFLLLAQIFYFYIIIQLPKLLKEPFSPVFSAFTFPLVISATALKNSLPVLMFPDIWKGLLFIEVLLATVIVLRVFIGYLHFFLKKEKQDKFLRNASQ
>NC_022604.1|WP_001245802.1|1239683_1239872_+|hypothetical-protein
MRNQIQKLLDSDLSSLHISKQTGVPQSTIHRMRKNERSLDNMSLKNAELLYKFANSIFSNEN
>NC_022604.1|WP_000398672.1|1240783_1240918_+|beta-class-phenol-soluble-modulin
MEGLFNAIKDTVTAAINNDGAKLGTSIVSIVENGVGLLGKLFGF

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_022604_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022604_9

2360908-2361058

Orphan

Consensus_repeat	Method
AACTTTAGTTGTTAGGGGCTCTTATGCA	CRISPRCasFinder

2 spacers

csa3

The CRISPR arrays of NC_022604_9

>merge|NC_022604|9|2360908-2361058|CRISPRCasFinder
AACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTAAACTTTAGTTGTTAGGGGCTCTTATGCAGTTGATGCGTAGCATCCAACTGTGTTCCTCTATTTTTCAACTTTAGTTGTTAGGGGCTTCTTTCTA

>NC_022604|9|8|2360908-2361058|CRISPRCasFinder
AACTTTAGTTGTTAGGGGCTCTTATGCA	TGCGCTTAGCGCAGGCGCTCCTACTTTTA
AACTTTAGTTGTTAGGGGCTCTTATGCA	GTTGATGCGTAGCATCCAACTGTGTTCCTCTATTTTTC
AACTTTAGTTGTTAGGGGCTTCTTTCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022604.1\|WP_000808817.1\|2355779_2356010_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000927363.1\|2370401_2372534_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_022604.1\|WP_000160304.1\|2351389_2352100_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_022604.1\|WP_000334467.1\|2366342_2368148_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_022604.1\|WP_000070866.1\|2352220_2352664_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NC_022604.1\|WP_000019744.1\|2358552_2359533_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NC_022604.1\|WP_001790138.1\|2363605_2363698_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000083789.1\|2368828_2370367_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_022604.1\|WP_001024094.1\|2357413_2358079_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NC_022604.1\|WP_001123303.1\|2352863_2353277_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NC_022604.1\|WP_000115564.1\|2362180_2363317_-\|SAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|366887
NC_022604.1\|WP_000495671.1\|2359798_2360890_+\|lytic-regulatory-protein	unknown	unknown	unknown
NC_022604.1\|WP_000370924.1\|2364403_2365261_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_022604.1\|WP_000123393.1\|2353734_2355108_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NC_022604.1\|WP_000003759.1\|2358230_2358551_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_022604.1\|WP_001292149.1\|2372545_2372980_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_022604.1\|WP_000908176.1\|2365328_2366111_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_022604.1\|WP_000648718.1\|2372979_2374086_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NC_022604.1\|WP_001802298.1\|2361389_2361494_-\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_001127960.1\|2356040_2356979_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399

Protein	Function_ID	Function_description	E-value
NC_022604.1\|WP_000927363.1\|2370401_2372534_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	4.09729e-67
NC_022604.1\|WP_000160304.1\|2351389_2352100_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NC_022604.1\|WP_000070866.1\|2352220_2352664_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.22744e-67
NC_022604.1\|WP_000019744.1\|2358552_2359533_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.049e-108
NC_022604.1\|WP_001127960.1\|2356040_2356979_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.24075e-129
NC_022604.1\|WP_000083789.1\|2368828_2370367_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_022604.1\|WP_001024094.1\|2357413_2358079_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.74381e-48
NC_022604.1\|WP_001123303.1\|2352863_2353277_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	3.14887e-46
NC_022604.1\|WP_000115564.1\|2362180_2363317_-\|SAP-domain-containing-protein	gnl\|CDD\|366887	pfam02037, SAP, SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.	3.91533e-06
NC_022604.1\|WP_000370924.1\|2364403_2365261_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	5.39747e-59
NC_022604.1\|WP_000123393.1\|2353734_2355108_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.86989e-06
NC_022604.1\|WP_000003759.1\|2358230_2358551_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NC_022604.1\|WP_001292149.1\|2372545_2372980_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
NC_022604.1\|WP_000334467.1\|2366342_2368148_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_022604.1\|WP_000648718.1\|2372979_2374086_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NC_022604.1\|WP_000908176.1\|2365328_2366111_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	4.88024e-103

>NC_022604.1|WP_000495671.1|2359798_2360890_+|lytic-regulatory-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYAQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NC_022604.1|WP_000019744.1|2358552_2359533_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>NC_022604.1|WP_000003759.1|2358230_2358551_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NC_022604.1|WP_001024094.1|2357413_2358079_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFDGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGDQDIKDALTQFENETD
>NC_022604.1|WP_001127960.1|2356040_2356979_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NC_022604.1|WP_000808817.1|2355779_2356010_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NC_022604.1|WP_000123393.1|2353734_2355108_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRISNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NC_022604.1|WP_001123303.1|2352863_2353277_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIKLITALPNRTKLLGVGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NC_022604.1|WP_000070866.1|2352220_2352664_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLENAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NC_022604.1|WP_000160304.1|2351389_2352100_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NC_022604.1|WP_001802298.1|2361389_2361494_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NC_022604.1|WP_000115564.1|2362180_2363317_-|SAP-domain-containing-protein
MSVNARDLLVLHTNVNRLVGEEIFANKCLANNDVQIMNSIKKLIEAELLTTTNDFEVSIYKKTRPELQSILKSFGIKTTGNKPDLIKRIDDNFHIINNLDLPYVYIPTKKGEEILKKTEYLTSFIQSYGEISLERAYYLVENYIDENCDDKVAEIYKFEFQRKYDNGEFDFNHGYNFELNMLIDHYKRDVKDYDNARKYSNIYLYFGLRDFLKKLMSNYSYYDSKGNIDLNEIQNDLNRFINSSASGMYERLIYNENLSNNIMFELFKKDTQDYSDLEEQLIEKFINYVVSNVKKESRSNTLIELSKILENGYTIDKEEFKKEDDYLSKYIFTDIDYLKKLESKINVAIDIRSGEIHLVLDDDSLDILIQNQKYGNEF
>NC_022604.1|WP_001790138.1|2363605_2363698_+|hypothetical-protein
MFIFKTTSKSHFHNNVKSLECIKIPINKNR
>NC_022604.1|WP_000370924.1|2364403_2365261_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINQLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQITNLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAEHFLAE
>NC_022604.1|WP_000908176.1|2365328_2366111_-|ABC-transporter-ATP-binding-protein
MLIQLDQIGRMKQGKTILKKISWQIAKGDKWILYGLNGAGKTTLLNILNAYEPATSGTVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEIRNEAHQLLKLVGMFAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITANFSKILLLKDGQSIQQGAVEDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NC_022604.1|WP_000334467.1|2366342_2368148_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDTPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>NC_022604.1|WP_000083789.1|2368828_2370367_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRFQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NC_022604.1|WP_000927363.1|2370401_2372534_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGTDSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVNKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDVDGNTSFENEQTSYLTSVFEKHLSDEKSEQLLHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFISDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NC_022604.1|WP_001292149.1|2372545_2372980_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>NC_022604.1|WP_000648718.1|2372979_2374086_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVEDSSIEAGLRRVLAETSQYITNEFDFTEAEQAAYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS

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Crispr_ID: NC_022604_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022604_10

2485072-2485265

Orphan

Consensus_repeat	Method
TGTTGGGGCCCCGCCAACTTGCA	CRT

3 spacers

The CRISPR arrays of NC_022604_10

>merge|NC_022604|10|2485072-2485265|CRT
TGTTGGGGCCCCGCCAACTTGCACATTATTGTATGCTGACTTTTCGTCACCTTCTGTGTTGGGGCCCCGTTCCCCAACTTGCATTGTCTGTAGAATTTCTTTTTGAAATTCTCTATGTTGGGGCCCCGCCAACTTGCACATTATTGTAAGCTGACTTTCTGTCAGCTTCTGTGTTGGGGCCCCGCCAACTTGTA

>NC_022604|10|2|2485072-2485265|CRT
TGTTGGGGCCCCGCCAACTTGCA	CATTATTGTATGCTGACTTTTCGTCACCTTCTG
TGTTGGGGCCCCGTTCCCCAACT	TGCATTGTCTGTAGAATTTCTTTTTGAAATTCTCTA
TGTTGGGGCCCCGCCAACTTGCA	CATTATTGTAAGCTGACTTTCTGTCAGCTTCTG
TGTTGGGGCCCCGCCAACTTGTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022604.1\|WP_000866971.1\|2487054_2487288_-\|molybdopterin-converting-factor-subunit-1	unknown	unknown	gnl\|CDD\|340452
NC_022604.1\|WP_000076929.1\|2490590_2491595_-\|molybdopterin-biosynthesis-protein-MoeB	unknown	unknown	gnl\|CDD\|181084
NC_022604.1\|WP_001549681.1\|2481450_2481702_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000184419.1\|2483052_2484264_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NC_022604.1\|WP_000600967.1\|2481693_2482458_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|379203
NC_022604.1\|WP_000503817.1\|2490053_2490560_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	unknown	unknown	gnl\|CDD\|223595
NC_022604.1\|WP_000602937.1\|2487753_2488239_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|224677
NC_022604.1\|WP_000808500.1\|2487293_2487740_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|223391
NC_022604.1\|WP_000592303.1\|2476512_2479680_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NC_022604.1\|WP_000259718.1\|2488235_2489495_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NC_022604.1\|WP_001790034.1\|2484841_2485012_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000413865.1\|2479796_2481062_-\|lipid-II:glycine-glycyltransferase-FemX	unknown	unknown	gnl\|CDD\|225224
NC_022604.1\|WP_000066900.1\|2484365_2484716_-\|HTH-type-transcriptional-regulator-SarV	unknown	unknown	gnl\|CDD\|130944
NC_022604.1\|WP_000230173.1\|2485406_2486429_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|274250
NC_022604.1\|WP_000134528.1\|2489557_2490052_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NC_022604.1\|WP_001161085.1\|2476008_2476326_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000051206.1\|2475599_2475764_+\|hypothetical-protein	unknown	unknown	unknown
NC_022604.1\|WP_000951058.1\|2482619_2483060_+\|winged-helix-DNA-binding-protein	unknown	unknown	gnl\|CDD\|197670
NC_022604.1\|WP_000913019.1\|2491764_2492370_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226628
NC_022604.1\|WP_000643988.1\|2486448_2487048_-\|molybdenum-cofactor-guanylyltransferase-MobA	unknown	unknown	gnl\|CDD\|234725

Protein	Function_ID	Function_description	E-value
NC_022604.1\|WP_000866971.1\|2487054_2487288_-\|molybdopterin-converting-factor-subunit-1	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	8.16473e-25
NC_022604.1\|WP_000076929.1\|2490590_2491595_-\|molybdopterin-biosynthesis-protein-MoeB	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	3.67241e-132
NC_022604.1\|WP_000184419.1\|2483052_2484264_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.27961e-72
NC_022604.1\|WP_000600967.1\|2481693_2482458_-\|VOC-family-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	1.50083e-38
NC_022604.1\|WP_000503817.1\|2490053_2490560_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	1.02752e-64
NC_022604.1\|WP_000602937.1\|2487753_2488239_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl\|CDD\|224677	COG1763, MobB, Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism].	4.35501e-50
NC_022604.1\|WP_000808500.1\|2487293_2487740_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	5.56799e-58
NC_022604.1\|WP_000592303.1\|2476512_2479680_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NC_022604.1\|WP_000259718.1\|2488235_2489495_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	9.49423e-160
NC_022604.1\|WP_000413865.1\|2479796_2481062_-\|lipid-II:glycine-glycyltransferase-FemX	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	4.8324e-143
NC_022604.1\|WP_000066900.1\|2484365_2484716_-\|HTH-type-transcriptional-regulator-SarV	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.64009e-20
NC_022604.1\|WP_000230173.1\|2485406_2486429_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.0538e-165
NC_022604.1\|WP_000134528.1\|2489557_2490052_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	3.63862e-98
NC_022604.1\|WP_000643988.1\|2486448_2487048_-\|molybdenum-cofactor-guanylyltransferase-MobA	gnl\|CDD\|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	5.68918e-67
NC_022604.1\|WP_000951058.1\|2482619_2483060_+\|winged-helix-DNA-binding-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.35323e-15
NC_022604.1\|WP_000913019.1\|2491764_2492370_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226628	COG4148, ModC, ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism].	3.32197e-115

>NC_022604.1|WP_001790034.1|2484841_2485012_+|hypothetical-protein
MFRFISFGQLVVYSTTFIPKKDILQLNGMECDINVKEPLKIYYVVILKSGIEMIFS
>NC_022604.1|WP_000066900.1|2484365_2484716_-|HTH-type-transcriptional-regulator-SarV
MSNKVQRFIEAERELSQLKHWLKTTHKISIEEFVVLFKVYEAEKISGKELRDTLHFEMLWDTSKIDVIIRKIYKKELISKLRSETDERQVFYFYSTSQKKLLDKITKEIEVLSVTN
>NC_022604.1|WP_000184419.1|2483052_2484264_+|MFS-transporter
MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLFIVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAVVTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILGILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILTYLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCLISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPSFLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
>NC_022604.1|WP_000951058.1|2482619_2483060_+|winged-helix-DNA-binding-protein
MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEKPTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNISQDQMQETINVMNQIHEILLKEAHND
>NC_022604.1|WP_000600967.1|2481693_2482458_-|VOC-family-protein
MILKFDHIIHYIDQLDRFSFPGDVIKLHSGGYHHKYGTFNKLGYINENYIELLDVENNEKLKKMAKTIEGGVAFATQIVQEKYEQGFKNICLRTNDIEAVKNKLQSEQVEVVGPIQMERDTHKDGKVKWQLLYIMNQDDDEIKPPFFIQWEESDSMRTKKLQKYFQKQFSIETVIVKSKNRSQTVSNWLKWFDMDIVEENDHYTDLILKNDDIYFRIEDGKVSKYHSVIIKDAQATSPYSIFIRGAIYRFEPLV
>NC_022604.1|WP_001549681.1|2481450_2481702_+|hypothetical-protein
MRTIILSLFIIMNIVAIIMTLSQPLTVNYFSLRVILIFFTFILSIFFILIKSSRLNNILTILSIVLVIIHMGILAHSTYVYLY
>NC_022604.1|WP_000413865.1|2479796_2481062_-|lipid-II:glycine-glycyltransferase-FemX
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMKTSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKRK
>NC_022604.1|WP_000592303.1|2476512_2479680_-|efflux-RND-transporter-permease-subunit
MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLTLAGGQGQSQSQSDNKQNSAMSDVNQASPQQNSKASAPNNISGMPTAKLGDLADITVGDVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWIVIILSTLILVATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHADGFKHPGEWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR
>NC_022604.1|WP_001161085.1|2476008_2476326_+|hypothetical-protein
MQFYLILLAILYLIVSFISIFKMEVVFTRILRIIMGVLLLFVLALTTMSFPKENWWVFIVLLLLVGNVEVTGFKMLKKDLKGVNILNLMSLFIFVIYFILTIVLF
>NC_022604.1|WP_000051206.1|2475599_2475764_+|hypothetical-protein
MSLENQLAELKYDYVRLQGDIEKRESLNLDTSALVRQLKDIENEIRNVRAQMQD
>NC_022604.1|WP_000230173.1|2485406_2486429_-|GTP-3',8-cyclase-MoaA
MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
>NC_022604.1|WP_000643988.1|2486448_2487048_-|molybdenum-cofactor-guanylyltransferase-MobA
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
>NC_022604.1|WP_000866971.1|2487054_2487288_-|molybdopterin-converting-factor-subunit-1
MKVLYFAEIKDILQKAQEDIVLEQALTVQQFEDLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
>NC_022604.1|WP_000808500.1|2487293_2487740_-|molybdenum-cofactor-biosynthesis-protein-MoaE
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>NC_022604.1|WP_000602937.1|2487753_2488239_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MILQIVGYKKSGKTTLMRHIVSFLKSHGYTVATIKHHGHGKEDIQLQDSDVDHMKHFEAGADQSIVQGFQYQQTVTRVDNQNLTQIIEKSVTIDTNIVLVEGFKNADFEKVVVYRNEEELQVLQQLSNVCYSINVREHEDFTAFEQWLLNKIKNDCDTQLT
>NC_022604.1|WP_000259718.1|2488235_2489495_-|molybdopterin-molybdotransferase-MoeA
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETKTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQKDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFVDGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
>NC_022604.1|WP_000134528.1|2489557_2490052_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIFKQISNNTNTKGNVLNTAQIAGIMAAKNTSTLIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSNQ
>NC_022604.1|WP_000503817.1|2490053_2490560_-|molybdenum-cofactor-biosynthesis-protein-MoaB
MGEHQNVKLNRTVKAAVLTVSDTRDFDTDKGGQCVRQLLQADDVEVSDAHYTIVKDEKVAITTQVKKWLEEDIDVIITTGGTGIAQRDVTIEAVKPLLTKEIDGFGELFRYLSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPELNHLIHELTK
>NC_022604.1|WP_000076929.1|2490590_2491595_-|molybdopterin-biosynthesis-protein-MoeB
MSQERYSRQILFKQIGEIGQSKINQKCALIIGMGALGTHVAEGLVRAGIAKLIIVDRDYIEFSNLQRQTLFTEEDALKMMPKVVAAKKHLLALRSDVDIDDYIAHVDYYFLETHGQDVDVIIDATDNFETRQLINDFAYKYRIPWIYGGVVQSTYTEAAFIPGKTPCFNCLVPQLPALNLTCDTVGVIQPAVTMATSLQLRDAMKVLTEQPIDTKITYGDIWEGSHYSFGFSKMQRSDCTTCGDVPSYPYLNKNEQRYATLCGRDTVQYENASITHDILVQFLKQHQLNYRSNSYMVMFEFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG
>NC_022604.1|WP_000913019.1|2491764_2492370_-|ATP-binding-cassette-domain-containing-protein
MLKINVKYQLKNTLIRINIDDTEPKIYAVRGPSGIGKTTVLNMIAGLRKADEAIIEVNGQLLTDTAKNVNVKIQQRRIGYLFQDYQLFPNMTVYKNITFMAEPSEHIDQLIQTLNIDHLMKQYPMTLSGGEAQRVALARALSTKPDLILLDEPFSSLDDTTKDESITLVKRIFNEWQIPIIFVTHSNYEAEQMAHEIITIG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022604_5	5.1\|904979\|34\|NC_022604\|CRISPRCasFinder	904979-905012	34	NC_022604.1	1441713-1441746	0	1.0
NC_022604_5	5.1\|904979\|34\|NC_022604\|CRISPRCasFinder	904979-905012	34	NC_022604.1	1530747-1530780	0	1.0
NC_022604_10	10.2\|2485151\|36\|NC_022604\|CRT	2485151-2485186	36	NC_022604.1	1230827-1230862	0	1.0
NC_022604_4	4.1\|855113\|29\|NC_022604\|CRISPRCasFinder	855113-855141	29	NC_022604.1	391559-391587	1	0.966
NC_022604_4	4.1\|855113\|29\|NC_022604\|CRISPRCasFinder	855113-855141	29	NC_022604.1	1897760-1897788	1	0.966
NC_022604_7	7.1\|1225412\|35\|NC_022604\|CRT	1225412-1225446	35	NC_022604.1	1225356-1225390	1	0.971
NC_022604_7	7.3\|1225525\|35\|NC_022604\|CRT	1225525-1225559	35	NC_022604.1	1225356-1225390	1	0.971
NC_022604_7	7.5\|1225637\|35\|NC_022604\|CRT	1225637-1225671	35	NC_022604.1	2169821-2169855	1	0.971
NC_022604_7	7.6\|1225540\|20\|NC_022604\|PILER-CR	1225540-1225559	20	NC_022604.1	1225371-1225390	1	0.95
NC_022604_8	8.1\|1230926\|26\|NC_022604\|CRISPRCasFinder	1230926-1230951	26	NC_022604.1	317131-317156	1	0.962
NC_022604_8	8.1\|1230926\|26\|NC_022604\|CRISPRCasFinder	1230926-1230951	26	NC_022604.1	823563-823588	1	0.962
NC_022604_8	8.1\|1230926\|26\|NC_022604\|CRISPRCasFinder	1230926-1230951	26	NC_022604.1	860515-860540	1	0.962
NC_022604_10	10.2\|2485151\|36\|NC_022604\|CRT	2485151-2485186	36	NC_022604.1	1897753-1897788	1	0.972
NC_022604_4	4.1\|855113\|29\|NC_022604\|CRISPRCasFinder	855113-855141	29	NC_022604.1	317263-317291	2	0.931
NC_022604_4	4.1\|855113\|29\|NC_022604\|CRISPRCasFinder	855113-855141	29	NC_022604.1	905021-905049	2	0.931
NC_022604_4	4.1\|855113\|29\|NC_022604\|CRISPRCasFinder	855113-855141	29	NC_022604.1	987928-987956	2	0.931
NC_022604_4	4.1\|855113\|29\|NC_022604\|CRISPRCasFinder	855113-855141	29	NC_022604.1	1230834-1230862	2	0.931
NC_022604_4	4.1\|855113\|29\|NC_022604\|CRISPRCasFinder	855113-855141	29	NC_022604.1	1709852-1709880	2	0.931
NC_022604_4	4.1\|855113\|29\|NC_022604\|CRISPRCasFinder	855113-855141	29	NC_022604.1	2063611-2063639	2	0.931
NC_022604_4	4.1\|855113\|29\|NC_022604\|CRISPRCasFinder	855113-855141	29	NC_022604.1	2678006-2678034	2	0.931
NC_022604_7	7.5\|1225637\|35\|NC_022604\|CRT	1225637-1225671	35	NC_022604.1	814017-814051	2	0.943
NC_022604_7	7.5\|1225637\|35\|NC_022604\|CRT	1225637-1225671	35	NC_022604.1	860551-860585	2	0.943
NC_022604_7	7.5\|1225637\|35\|NC_022604\|CRT	1225637-1225671	35	NC_022604.1	2792659-2792693	2	0.943
NC_022604_8	8.1\|1230926\|26\|NC_022604\|CRISPRCasFinder	1230926-1230951	26	NC_022604.1	823507-823532	2	0.923
NC_022604_8	8.1\|1230926\|26\|NC_022604\|CRISPRCasFinder	1230926-1230951	26	NC_022604.1	823619-823644	2	0.923
NC_022604_8	8.1\|1230926\|26\|NC_022604\|CRISPRCasFinder	1230926-1230951	26	NC_022604.1	968402-968427	2	0.923
NC_022604_10	10.1\|2485095\|33\|NC_022604\|CRT	2485095-2485127	33	NC_022604.1	1230883-1230915	2	0.939
NC_022604_10	10.1\|2485095\|33\|NC_022604\|CRT	2485095-2485127	33	NC_022604.1	1441668-1441700	2	0.939
NC_022604_10	10.1\|2485095\|33\|NC_022604\|CRT	2485095-2485127	33	NC_022604.1	1530793-1530825	2	0.939
NC_022604_10	10.1\|2485095\|33\|NC_022604\|CRT	2485095-2485127	33	NC_022604.1	2052867-2052899	2	0.939
NC_022604_10	10.1\|2485095\|33\|NC_022604\|CRT	2485095-2485127	33	NC_022604.1	2758391-2758423	2	0.939
NC_022604_10	10.2\|2485151\|36\|NC_022604\|CRT	2485151-2485186	36	NC_022604.1	317256-317291	2	0.944
NC_022604_10	10.2\|2485151\|36\|NC_022604\|CRT	2485151-2485186	36	NC_022604.1	1709852-1709887	2	0.944
NC_022604_10	10.2\|2485151\|36\|NC_022604\|CRT	2485151-2485186	36	NC_022604.1	2063611-2063646	2	0.944
NC_022604_10	10.3\|2485210\|33\|NC_022604\|CRT	2485210-2485242	33	NC_022604.1	860495-860527	2	0.939
NC_022604_10	10.3\|2485210\|33\|NC_022604\|CRT	2485210-2485242	33	NC_022604.1	1230883-1230915	2	0.939
NC_022604_10	10.3\|2485210\|33\|NC_022604\|CRT	2485210-2485242	33	NC_022604.1	1441668-1441700	2	0.939
NC_022604_10	10.3\|2485210\|33\|NC_022604\|CRT	2485210-2485242	33	NC_022604.1	2052867-2052899	2	0.939
NC_022604_10	10.3\|2485210\|33\|NC_022604\|CRT	2485210-2485242	33	NC_022604.1	2758391-2758423	2	0.939

1. spacer 5.1|904979|34|NC_022604|CRISPRCasFinder matches to position: 1441713-1441746, mismatch: 0, identity: 1.0

attgggaatccaatttctctttgttggggcccat	CRISPR spacer
attgggaatccaatttctctttgttggggcccat	Protospacer
**********************************

2. spacer 5.1|904979|34|NC_022604|CRISPRCasFinder matches to position: 1530747-1530780, mismatch: 0, identity: 1.0

attgggaatccaatttctctttgttggggcccat	CRISPR spacer
attgggaatccaatttctctttgttggggcccat	Protospacer
**********************************

3. spacer 10.2|2485151|36|NC_022604|CRT matches to position: 1230827-1230862, mismatch: 0, identity: 1.0

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgtctgtagaatttctttttgaaattctcta	Protospacer
************************************

4. spacer 4.1|855113|29|NC_022604|CRISPRCasFinder matches to position: 391559-391587, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcttgtagaatttcttttcgaaa	Protospacer
*******.*********************

5. spacer 4.1|855113|29|NC_022604|CRISPRCasFinder matches to position: 1897760-1897788, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaa	Protospacer
********.********************

6. spacer 7.1|1225412|35|NC_022604|CRT matches to position: 1225356-1225390, mismatch: 1, identity: 0.971

cagagagaaataggatcaccaatttcaacagacaa	CRISPR spacer
cagagagaaataggatcaccaattccaacagacaa	Protospacer
************************.**********

7. spacer 7.3|1225525|35|NC_022604|CRT matches to position: 1225356-1225390, mismatch: 1, identity: 0.971

cagagagaaataggatcaccaattccaacaaacaa	CRISPR spacer
cagagagaaataggatcaccaattccaacagacaa	Protospacer
******************************.****

8. spacer 7.5|1225637|35|NC_022604|CRT matches to position: 2169821-2169855, mismatch: 1, identity: 0.971

catagagaaattggaaccccaatttctacagacaa	CRISPR spacer
catagagaaattggaacaccaatttctacagacaa	Protospacer
***************** *****************

9. spacer 7.6|1225540|20|NC_022604|PILER-CR matches to position: 1225371-1225390, mismatch: 1, identity: 0.95

tcaccaattccaacaaacaa	CRISPR spacer
tcaccaattccaacagacaa	Protospacer
***************.****

10. spacer 8.1|1230926|26|NC_022604|CRISPRCasFinder matches to position: 317131-317156, mismatch: 1, identity: 0.962

cggggccccaacatagaagctggcgg	CRISPR spacer
cgggcccccaacatagaagctggcgg	Protospacer
**** *********************

11. spacer 8.1|1230926|26|NC_022604|CRISPRCasFinder matches to position: 823563-823588, mismatch: 1, identity: 0.962

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacatagaagcaggcgg	Protospacer
******************** *****

12. spacer 8.1|1230926|26|NC_022604|CRISPRCasFinder matches to position: 860515-860540, mismatch: 1, identity: 0.962

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacacagaagctggcgg	Protospacer
*************.************

13. spacer 10.2|2485151|36|NC_022604|CRT matches to position: 1897753-1897788, mismatch: 1, identity: 0.972

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaattctcta	Protospacer
************************.***********

14. spacer 4.1|855113|29|NC_022604|CRISPRCasFinder matches to position: 317263-317291, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

15. spacer 4.1|855113|29|NC_022604|CRISPRCasFinder matches to position: 905021-905049, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

16. spacer 4.1|855113|29|NC_022604|CRISPRCasFinder matches to position: 987928-987956, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

17. spacer 4.1|855113|29|NC_022604|CRISPRCasFinder matches to position: 1230834-1230862, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttctttttgaaa	Protospacer
********.***************.****

18. spacer 4.1|855113|29|NC_022604|CRISPRCasFinder matches to position: 1709852-1709880, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

19. spacer 4.1|855113|29|NC_022604|CRISPRCasFinder matches to position: 2063611-2063639, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcctttcgaaa	Protospacer
********.***********.********

20. spacer 4.1|855113|29|NC_022604|CRISPRCasFinder matches to position: 2678006-2678034, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

21. spacer 7.5|1225637|35|NC_022604|CRT matches to position: 814017-814051, mismatch: 2, identity: 0.943

catagagaaattggaaccccaatttctacagacaa	CRISPR spacer
catagagaaattggattcccaatttctacagacaa	Protospacer
*************** .******************

22. spacer 7.5|1225637|35|NC_022604|CRT matches to position: 860551-860585, mismatch: 2, identity: 0.943

catagagaaattggaaccccaatttctacagacaa	CRISPR spacer
catagagaaattggattcccaatttctacagacaa	Protospacer
*************** .******************

23. spacer 7.5|1225637|35|NC_022604|CRT matches to position: 2792659-2792693, mismatch: 2, identity: 0.943

catagagaaattggaaccccaatttctacagacaa	CRISPR spacer
catagagaaattggattcccaatttctacagacaa	Protospacer
*************** .******************

24. spacer 8.1|1230926|26|NC_022604|CRISPRCasFinder matches to position: 823507-823532, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacacagaagcaggcgg	Protospacer
*************.****** *****

25. spacer 8.1|1230926|26|NC_022604|CRISPRCasFinder matches to position: 823619-823644, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacataaaagcaggcgg	Protospacer
***************.**** *****

26. spacer 8.1|1230926|26|NC_022604|CRISPRCasFinder matches to position: 968402-968427, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacacagaggctggcgg	Protospacer
*************.***.********

27. spacer 10.1|2485095|33|NC_022604|CRT matches to position: 1230883-1230915, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********** *************** ******

28. spacer 10.1|2485095|33|NC_022604|CRT matches to position: 1441668-1441700, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********** *************** ******

29. spacer 10.1|2485095|33|NC_022604|CRT matches to position: 1530793-1530825, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcatcttctg	Protospacer
********** ***************.******

30. spacer 10.1|2485095|33|NC_022604|CRT matches to position: 2052867-2052899, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********** *************** ******

31. spacer 10.1|2485095|33|NC_022604|CRT matches to position: 2758391-2758423, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********** *************** ******

32. spacer 10.2|2485151|36|NC_022604|CRT matches to position: 317256-317291, mismatch: 2, identity: 0.944

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaattctcta	Protospacer
*******.****************.***********

33. spacer 10.2|2485151|36|NC_022604|CRT matches to position: 1709852-1709887, mismatch: 2, identity: 0.944

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaattctcta	Protospacer
*******.****************.***********

34. spacer 10.2|2485151|36|NC_022604|CRT matches to position: 2063611-2063646, mismatch: 2, identity: 0.944

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgtctgtagaatttcctttcgaaattctcta	Protospacer
********************.***.***********

35. spacer 10.3|2485210|33|NC_022604|CRT matches to position: 860495-860527, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgactttccgccagcttctg	Protospacer
*********************.*.*********

36. spacer 10.3|2485210|33|NC_022604|CRT matches to position: 1230883-1230915, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********************..***********

37. spacer 10.3|2485210|33|NC_022604|CRT matches to position: 1441668-1441700, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********************..***********

38. spacer 10.3|2485210|33|NC_022604|CRT matches to position: 2052867-2052899, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********************..***********

39. spacer 10.3|2485210|33|NC_022604|CRT matches to position: 2758391-2758423, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********************..***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022604_4	4.1\|855113\|29\|NC_022604\|CRISPRCasFinder	855113-855141	29	MN693281	Marine virus AFVG_25M371, complete genome	6448-6476	7	0.759
NC_022604_7	7.1\|1225412\|35\|NC_022604\|CRT	1225412-1225446	35	KY971610	Pseudomonas phage PspYZU05, complete genome	73937-73971	11	0.686

1. spacer 4.1|855113|29|NC_022604|CRISPRCasFinder matches to MN693281 (Marine virus AFVG_25M371, complete genome) position: , mismatch: 7, identity: 0.759

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtttgtaggatttcttctaagtg	Protospacer
**************.*******.* .. .

2. spacer 7.1|1225412|35|NC_022604|CRT matches to KY971610 (Pseudomonas phage PspYZU05, complete genome) position: , mismatch: 11, identity: 0.686

cagagagaaataggatcaccaatttcaacagacaa	CRISPR spacer
ccacatgaaatagggtcaccaatttgaacagcttt	Protospacer
* . . ********.********** ***** .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

42622 : 90914

Streptococcus_phage(33.33%)

integrase,transposase

attL 44608:44624|attR 91691:91707

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000093392.1\|42622_43108_+\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	4.9e-19	35.4
WP_000175892.1\|43401_43740_+	hypothetical protein	NA	NA	NA	NA
WP_001166716.1\|43833_44145_+	hypothetical protein	NA	NA	NA	NA
WP_000848380.1\|44160_44667_+	DUF1643 domain-containing protein	NA	NA	NA	NA
44608:44624	attL	NA	NA	NA	NA
WP_023180038.1\|44687_45005_+	RadC family protein	NA	NA	NA	NA
WP_000868132.1\|45123_46209_+\|integrase	tyrosine-type recombinase/integrase	A0A0A8WIF9	Clostridium_phage	4.5e-12	28.3
WP_000361059.1\|48104_48482_+\|transposase	transposase	NA	NA	NA	NA
WP_000067268.1\|48632_49415_+	aminoglycoside nucleotidyltransferase ANT(9)-Ia	NA	NA	NA	NA
WP_001072201.1\|49540_50272_-	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	E4ZFQ0	Streptococcus_phage	1.9e-51	47.5
WP_001092058.1\|50780_51443_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_000373151.1\|51990_52863_+	HTH domain-containing protein	NA	NA	NA	NA
WP_000065262.1\|52919_53210_+	hypothetical protein	NA	NA	NA	NA
WP_000397419.1\|53225_53714_+	hypothetical protein	NA	NA	NA	NA
WP_000717928.1\|53848_54376_+	hypothetical protein	NA	NA	NA	NA
WP_000941331.1\|54438_54855_+	hypothetical protein	NA	NA	NA	NA
WP_001070883.1\|55321_55543_+	hypothetical protein	NA	NA	NA	NA
WP_000759939.1\|55694_56261_+	peptidase	NA	NA	NA	NA
WP_000231163.1\|56340_58530_-	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	1.4e-41	25.8
WP_023180042.1\|58615_59290_-\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	5.4e-125	97.3
WP_023180046.1\|59572_60919_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_000525462.1\|61218_61626_+	Hg(II)-responsive transcriptional regulator MerR	NA	NA	NA	NA
WP_000746202.1\|61642_62128_+	TlpA family protein disulfide reductase	NA	NA	NA	NA
WP_000010352.1\|62124_62805_+	cytochrome c biosynthesis protein	NA	NA	NA	NA
WP_001794630.1\|62892_63279_+	mercuric transport protein MerT	NA	NA	NA	NA
WP_000193219.1\|63336_64980_+	mercury(II) reductase	A0A2K5B2C5	Erysipelothrix_phage	1.7e-50	29.4
WP_000790333.1\|65061_65712_+	organomercurial lyase MerB	NA	NA	NA	NA
WP_000377078.1\|65906_66422_-	hypothetical protein	NA	NA	NA	NA
WP_001105968.1\|66540_67215_-\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	9.9e-127	98.7
WP_000122374.1\|68980_70222_+	plasmid recombination protein	NA	NA	NA	NA
WP_020444595.1\|72493_72883_+	hydroxymethylglutaryl-CoA synthase family protein	NA	NA	NA	NA
WP_000958858.1\|73959_74703_+	glycerophosphoryl diester phosphodiesterase	NA	NA	NA	NA
WP_000872606.1\|74799_75228_+	MaoC family dehydratase	NA	NA	NA	NA
WP_078056052.1\|75273_77283_-	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	NA	NA	NA	NA
WP_000952923.1\|77379_79137_+	beta-lactam sensor/signal transducer MecR1	NA	NA	NA	NA
WP_014532405.1\|79592_79661_-	phenol-soluble modulin PSM-mec	NA	NA	NA	NA
WP_000427807.1\|79980_81129_+	ROK family transcriptional regulator	NA	NA	NA	NA
WP_000438836.1\|82608_83673_-	dihydroneopterin aldolase	NA	NA	NA	NA
WP_000220507.1\|83808_84069_+	persulfide-sensing transcriptional repressor CstR	NA	NA	NA	NA
WP_000350222.1\|84068_84713_+	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_023180052.1\|85679_88094_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	7.9e-251	63.6
WP_000159127.1\|88086_88452_-	winged helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	7.7e-25	49.6
WP_001041908.1\|88637_89015_-	hypothetical protein	NA	NA	NA	NA
WP_014532403.1\|89021_90914_-\|integrase	phage integrase family protein	NA	NA	NA	NA
91691:91707	attR	NA	NA	NA	NA

DBSCAN-SWA_2

434836 : 450840

Streptococcus_phage(76.92%)

integrase

attL 430744:430758|attR 446673:446687

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
430744:430758	attL	NA	NA	NA	NA
WP_000264071.1\|434836_436303_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	5.2e-96	40.5
WP_000424966.1\|436327_437869_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	1.2e-23	32.6
WP_000237797.1\|437936_439130_-\|integrase	site-specific integrase	A0A0S2MV79	Bacillus_phage	8.3e-44	34.2
WP_000633907.1\|439156_439357_-	DUF3173 family protein	NA	NA	NA	NA
WP_000845143.1\|439854_440085_-	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	1.0e-27	78.9
WP_000804879.1\|440081_440504_-	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	7.5e-48	68.6
WP_001227350.1\|441034_441388_+	helix-turn-helix transcriptional regulator	A0A1S5SFA6	Streptococcus_phage	2.2e-53	89.7
WP_032506803.1\|441445_441634_-	conjugal transfer protein	D0R0F6	Streptococcus_phage	7.4e-16	61.4
WP_000691737.1\|441731_443651_-	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	97.2
WP_001791010.1\|443666_443783_-	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_000584387.1\|444027_444957_-	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	1.1e-83	56.6
WP_000768373.1\|444973_445996_-	peptidase P60	A0A1S5SEZ8	Streptococcus_phage	2.4e-132	75.5
WP_000192392.1\|445992_448020_-	membrane protein	A0A1S5SF30	Streptococcus_phage	2.3e-195	65.5
446673:446687	attR	NA	NA	NA	NA
WP_000331167.1\|448016_450461_-	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	78.4
WP_000723887.1\|450444_450840_-	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	5.9e-47	72.6

DBSCAN-SWA_3

457277 : 465444

Streptococcus_phage(85.71%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000870467.1\|457277_457772_-	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	2.8e-54	63.4
WP_000675717.1\|457838_458618_-	abortive infection family protein	NA	NA	NA	NA
WP_001009054.1\|458659_458881_-	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	3.1e-29	93.2
WP_000055376.1\|458877_459168_-	hypothetical protein	NA	NA	NA	NA
WP_000426689.1\|459164_460349_-	XRE family transcriptional regulator	A0A1S5SEX3	Streptococcus_phage	6.3e-161	68.1
WP_001130245.1\|460530_461934_-	DUF87 domain-containing protein	A0A1S5SFB5	Streptococcus_phage	7.5e-177	66.7
WP_000185761.1\|461955_462729_-	hypothetical protein	NA	NA	NA	NA
WP_001234191.1\|462738_463116_-	YdcP family protein	A0A1S5SF96	Streptococcus_phage	9.6e-47	76.4
WP_000421279.1\|463136_463451_-	YdcP family protein	A0A1S5SF38	Streptococcus_phage	1.2e-42	77.7
WP_000181735.1\|463650_465444_-	ATP-dependent helicase	E3T5J8	Cafeteria_roenbergensis_virus	6.9e-26	23.8

DBSCAN-SWA_4

792142 : 799962

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244412.1\|792142_793198_-	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	2.1e-14	30.0
WP_000149344.1\|793197_793884_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037807.1\|793858_794332_-	DoxX family protein	NA	NA	NA	NA
WP_001093553.1\|794673_795114_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637687.1\|795393_795978_-	hypothetical protein	NA	NA	NA	NA
WP_001062972.1\|796076_796790_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941338.1\|796793_797213_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	3.7e-07	28.7
WP_000446724.1\|797214_797883_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604514.1\|798233_798827_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.4e-38	42.9
WP_001217785.1\|798810_799962_+	anthranilate synthase component I family protein	A0A0B5J984	Pandoravirus	1.6e-23	35.7

DBSCAN-SWA_5

811934 : 826721

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663030.1\|811934_812993_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	7.9e-22	26.7
WP_000197271.1\|813343_813886_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429014.1\|814565_815483_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	3.7e-07	22.0
WP_001790641.1\|815573_815675_+	hypothetical protein	NA	NA	NA	NA
WP_000193751.1\|815752_817258_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930014.1\|817598_818099_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.9e-52	71.5
WP_001068497.1\|818118_818985_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|819785_820184_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855505.1\|820146_822252_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|822369_823341_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000499195.1\|823854_824010_+	hypothetical protein	NA	NA	NA	NA
WP_000876318.1\|824048_825020_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.3e-139	78.9
WP_001245577.1\|825006_825963_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000616842.1\|825959_826721_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	8.5e-18	31.6

DBSCAN-SWA_6

906517 : 921325

Staphylococcus_phage(89.47%)

terminase,coat,integrase

attL 909052:909070|attR 923614:923632

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000571218.1\|906517_907543_+	methionine ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.2e-27	36.8
WP_023180111.1\|907535_908231_+	ABC transporter permease	NA	NA	NA	NA
WP_000732326.1\|908248_909070_+	MetQ/NlpA family ABC transporter substrate-binding protein	NA	NA	NA	NA
909052:909070	attL	NA	NA	NA	NA
WP_000264182.1\|909213_910434_-\|integrase	site-specific integrase	Q4ZE80	Staphylococcus_phage	3.5e-98	47.3
WP_000733773.1\|910521_911250_-	staphylococcal enterotoxin type K	A0EX09	Staphylococcus_phage	2.4e-22	32.3
WP_001033317.1\|911273_912002_-	staphylococcal enterotoxin type Q	A0EX09	Staphylococcus_phage	7.9e-29	35.4
WP_000142630.1\|912176_912911_-	helix-turn-helix transcriptional regulator	Q4ZE79	Staphylococcus_phage	8.5e-132	98.4
WP_001063624.1\|913060_913273_+	helix-turn-helix transcriptional regulator	Q4ZE78	Staphylococcus_phage	3.4e-33	98.6
WP_001138298.1\|913273_913546_+	winged helix-turn-helix domain-containing protein	Q4ZE77	Staphylococcus_phage	3.4e-46	100.0
WP_000784885.1\|913557_913704_+	hypothetical protein	NA	NA	NA	NA
WP_001058492.1\|913696_913906_+	hypothetical protein	Q4ZE76	Staphylococcus_phage	7.7e-30	95.7
WP_001103946.1\|913908_914202_+	DUF1474 family protein	A0A1W6JQH0	Staphylococcus_phage	1.8e-24	61.8
WP_001002691.1\|914289_915159_+	hypothetical protein	A0A1W6JQL5	Staphylococcus_phage	4.2e-162	96.9
WP_000432707.1\|915175_916633_+	hypothetical protein	A0A1W6JQD6	Staphylococcus_phage	1.4e-279	96.7
WP_001039172.1\|916934_917297_+	hypothetical protein	A0A1W6JQD5	Staphylococcus_phage	2.9e-64	96.7
WP_000998180.1\|917298_917583_+	hypothetical protein	A0A1W6JQE4	Staphylococcus_phage	1.6e-49	98.9
WP_001019783.1\|917579_918221_+	hypothetical protein	Q4ZE67	Staphylococcus_phage	2.7e-113	94.8
WP_001190616.1\|918669_919011_+	hypothetical protein	Q4ZE66	Staphylococcus_phage	1.6e-56	98.2
WP_000846279.1\|919022_919601_+	hypothetical protein	A0A2H4JBG0	uncultured_Caudovirales_phage	3.3e-30	40.0
WP_000448776.1\|919618_919837_+	hypothetical protein	NA	NA	NA	NA
WP_000771365.1\|919887_920415_+\|coat	spore coat protein	Q4ZE87	Staphylococcus_phage	1.6e-87	96.0
WP_025174984.1\|920546_920759_+	hypothetical protein	Q4ZE86	Staphylococcus_phage	3.2e-31	97.1
WP_001281786.1\|920755_921325_+\|terminase	terminase small subunit	A0A1W6JQF0	Staphylococcus_phage	1.2e-101	98.4
923614:923632	attR	NA	NA	NA	NA

DBSCAN-SWA_7

1088487 : 1096960

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000861572.1\|1088487_1088970_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7
WP_001010412.1\|1088956_1090081_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174053.1\|1090084_1090789_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	42.1
WP_000848350.1\|1090788_1091052_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666799.1\|1091053_1091725_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032727.1\|1091717_1093907_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.0e-140	39.7
WP_000483713.1\|1093885_1095370_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.2e-45	31.7
WP_000030812.1\|1095362_1096391_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.3e-61	41.4
WP_000238664.1\|1096393_1096960_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.1e-29	40.1

DBSCAN-SWA_8

1148617 : 1229761

100

Staphylococcus_phage(83.33%)

plate,portal,transposase,capsid,tRNA,head,holin,terminase,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000401377.1\|1148617_1149100_+	pantetheine-phosphate adenylyltransferase	A0A1B1IVQ3	uncultured_Mediterranean_phage	2.6e-28	46.2
WP_000843599.1\|1149161_1150301_-	nucleotidyltransferase	NA	NA	NA	NA
WP_000872158.1\|1150427_1150985_+	DUF177 domain-containing protein	NA	NA	NA	NA
WP_000290472.1\|1151064_1151238_+	50S ribosomal protein L32	NA	NA	NA	NA
WP_000861313.1\|1151354_1152740_-	recombinase family protein	I1W625	Staphylococcus_phage	2.5e-265	100.0
WP_000392109.1\|1152946_1153627_-	hypothetical protein	A0A2H4PQQ5	Staphylococcus_phage	5.1e-123	100.0
WP_000874708.1\|1153658_1154297_-	LexA family transcriptional regulator	A0EWH5	Staphylococcus_virus	1.1e-116	100.0
WP_001106626.1\|1154486_1154741_+	helix-turn-helix transcriptional regulator	C5I625	Staphylococcus_phage	1.4e-41	98.8
WP_000856472.1\|1154909_1155146_-	hypothetical protein	Q4ZBN3	Staphylococcus_phage	2.3e-38	98.7
WP_000933363.1\|1155593_1155779_+	helix-turn-helix transcriptional regulator	S4SUN2	Staphylococcus_phage	1.7e-25	100.0
WP_009560540.1\|1155780_1156533_+	phage antirepressor protein	A0A1X9H0A0	Staphylococcus_phage	1.1e-139	99.6
WP_000395457.1\|1156699_1156930_-	hypothetical protein	R4IG40	Staphylococcus_phage	2.3e-35	100.0
WP_000066026.1\|1157109_1157271_+	DUF1270 family protein	C8CGY5	Staphylococcus_phage	2.5e-20	100.0
WP_000291089.1\|1157364_1157625_+	DUF1108 family protein	Q4ZBM7	Staphylococcus_phage	1.2e-43	100.0
WP_023180128.1\|1157637_1158174_+	hypothetical protein	A0A0F6N4M6	Staphylococcus_phage	4.2e-80	99.4
WP_023180130.1\|1158174_1158822_+	ERF superfamily	A0A0F6N3I5	Staphylococcus_phage	7.5e-116	97.2
WP_023180131.1\|1158821_1159238_+	single-stranded DNA-binding protein	G4KNN8	Staphylococcus_phage	7.1e-59	83.7
WP_023180133.1\|1159251_1159947_+	hypothetical protein	Q9MBS0	Staphylococcus_prophage	8.9e-131	96.5
WP_000504974.1\|1159918_1160713_+	DnaD domain protein	Q8SDW2	Staphylococcus_phage	3.9e-106	98.5
WP_001132243.1\|1160712_1161069_+	hypothetical protein	M9NS37	Staphylococcus_phage	8.2e-64	100.0
WP_023180135.1\|1161065_1162307_+	AAA family ATPase	A9CR70	Staphylococcus_phage	3.3e-229	99.8
WP_001024398.1\|1162303_1162519_+	hypothetical protein	C8CGZ4	Staphylococcus_phage	3.7e-35	100.0
WP_001123688.1\|1162521_1162743_+	DUF3269 family protein	Q9G021	Staphylococcus_phage	1.3e-35	100.0
WP_023180136.1\|1162752_1163178_+	phage N-6-adenine-methyltransferase	C8CGZ6	Staphylococcus_phage	2.3e-81	99.3
WP_000049810.1\|1163174_1163579_+	DUF1064 domain-containing protein	A0A0H4ISQ5	Staphylococcus_phage	9.0e-67	100.0
WP_001187264.1\|1163583_1163769_+	DUF3113 family protein	D2JGK9	Staphylococcus_phage	7.0e-27	100.0
WP_000022735.1\|1164129_1164384_+	DUF3310 domain-containing protein	D2JGL1	Staphylococcus_phage	1.3e-42	100.0
WP_078065934.1\|1164383_1164632_+	hypothetical protein	A0A0K1LL46	Staphylococcus_phage	3.0e-41	97.6
WP_023180140.1\|1164644_1165049_+	hypothetical protein	A0A0E3T8H9	Staphylococcus_phage	6.6e-70	96.3
WP_001105618.1\|1165045_1165330_+	hypothetical protein	S4V9L1	Staphylococcus_phage	3.2e-47	100.0
WP_001065026.1\|1165322_1165571_+	DUF1024 family protein	S4V7K0	Staphylococcus_phage	4.1e-38	100.0
WP_000185669.1\|1165563_1166100_+	hypothetical protein	R4IG63	Staphylococcus_phage	9.4e-96	100.0
WP_020444716.1\|1166136_1166373_+	DUF1381 domain-containing protein	C8CH06	Staphylococcus_phage	9.0e-35	97.4
WP_020444715.1\|1166397_1166634_+	hypothetical protein	A7TWB3	Staphylococcus_phage	5.6e-37	98.7
WP_015988676.1\|1166626_1166800_+	int gene activator	A9CR97	Staphylococcus_phage	3.4e-23	100.0
WP_000286968.1\|1166800_1167202_+	hypothetical protein	A0A2H4PQK5	Staphylococcus_phage	5.6e-69	100.0
WP_000594085.1\|1167552_1168047_+	hypothetical protein	A0A0H4J343	Staphylococcus_phage	8.4e-83	100.0
WP_001807202.1\|1168039_1169248_+\|terminase	PBSX family phage terminase large subunit	A0A0H4ITX6	Staphylococcus_phage	1.0e-235	100.0
WP_001159669.1\|1169201_1170680_+\|portal	phage portal protein	Q4ZB45	Staphylococcus_virus	4.3e-284	99.6
WP_044119665.1\|1170618_1171599_+\|capsid	minor capsid protein	Q4ZAW9	Staphylococcus_virus	6.6e-180	98.8
WP_000366932.1\|1171696_1172293_+	hypothetical protein	R4IG73	Staphylococcus_phage	5.6e-73	100.0
WP_023180143.1\|1172313_1173138_+\|capsid	N4-gp56 family major capsid protein	A0A0H4J347	Staphylococcus_phage	7.3e-148	99.6
WP_000278802.1\|1173154_1173481_+	hypothetical protein	A0A0H4ITX8	Staphylococcus_phage	1.2e-50	100.0
WP_000338934.1\|1173480_1173795_+\|head,tail	phage head-tail adapter protein	A0A0H4IPX4	Staphylococcus_phage	2.6e-53	100.0
WP_000482988.1\|1173787_1174123_+\|head	phage head closure protein	A0A0H4ISR6	Staphylococcus_phage	1.0e-60	100.0
WP_023180145.1\|1174109_1174511_+	HK97 gp10 family phage protein	A0A0H4IPA6	Staphylococcus_phage	1.2e-71	96.4
WP_000270194.1\|1174523_1174961_+	DUF3168 domain-containing protein	A0A0H4J350	Staphylococcus_phage	7.9e-77	100.0
WP_000046067.1\|1174947_1175508_+	hypothetical protein	A0A0H4ITY2	Staphylococcus_phage	5.9e-101	100.0
WP_000141084.1\|1175569_1176064_+	hypothetical protein	A0A0H4IPX9	Staphylococcus_phage	2.5e-87	100.0
WP_000204079.1\|1176084_1176426_+	hypothetical protein	W5R8J4	Staphylococcus_phage	3.5e-56	100.0
WP_023180147.1\|1176428_1179398_+\|tail	phage tail length tape measure protein	A0A2H4PQM1	Staphylococcus_phage	1.9e-262	93.8
WP_000560199.1\|1179412_1180348_+\|tail	phage tail protein	A0A0H4J355	Staphylococcus_phage	4.8e-180	100.0
WP_023180149.1\|1180358_1182242_+	phage minor structural protein	A0A0H4ITY6	Staphylococcus_phage	0.0e+00	99.8
WP_023180150.1\|1182254_1184153_+	hypothetical protein	Q4ZBQ2	Staphylococcus_phage	0.0e+00	99.7
WP_023180152.1\|1184152_1185976_+\|plate	BppU family phage baseplate upper protein	Q4ZDD5	Staphylococcus_virus	2.5e-294	99.0
WP_000705893.1\|1185975_1186353_+	DUF2977 domain-containing protein	Q8LTH7	Staphylococcus_phage	7.3e-55	100.0
WP_001790193.1\|1186356_1186530_+	XkdX family protein	Q8LTH6	Staphylococcus_phage	1.7e-27	100.0
WP_023180153.1\|1186570_1186870_+	DUF2951 domain-containing protein	Q4ZBP8	Staphylococcus_phage	3.8e-46	99.0
WP_000524044.1\|1187006_1188881_+	CHAP domain-containing protein	A0A2I6PCX0	Staphylococcus_phage	0.0e+00	100.0
WP_000276641.1\|1188893_1190132_+\|plate	BppU family phage baseplate upper protein	E0Y3M8	Staphylococcus_virus	3.5e-210	100.0
WP_031782932.1\|1190136_1190532_+	hypothetical protein	S4SWE0	Staphylococcus_phage	4.4e-66	96.9
WP_000354128.1\|1190586_1191024_+\|holin	phage holin	S4SVG2	Staphylococcus_phage	4.1e-73	99.3
WP_023180154.1\|1191004_1192450_+	CHAP domain-containing protein	Q4ZB16	Staphylococcus_virus	1.8e-295	99.8
WP_023180156.1\|1193181_1195119_-	heme uptake protein IsdB	NA	NA	NA	NA
WP_000160859.1\|1195321_1196374_-	LPXTG-anchored heme-scavenging protein IsdA	NA	NA	NA	NA
WP_000789821.1\|1196582_1197266_+	heme uptake protein IsdC	NA	NA	NA	NA
WP_001246698.1\|1197265_1198342_+	hypothetical protein	NA	NA	NA	NA
WP_001220199.1\|1198338_1199217_+	heme ABC transporter substrate-binding protein IsdE	NA	NA	NA	NA
WP_001548422.1\|1199226_1200195_+	iron ABC transporter permease	NA	NA	NA	NA
WP_001242429.1\|1200256_1200991_+	class B sortase	NA	NA	NA	NA
WP_000670950.1\|1201009_1201333_+	staphylobilin-forming heme oxygenase IsdG	NA	NA	NA	NA
WP_001788617.1\|1201369_1201477_+	hypothetical protein	NA	NA	NA	NA
WP_000435374.1\|1201716_1202457_+	RNA methyltransferase	NA	NA	NA	NA
WP_000003559.1\|1202837_1203896_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2I2L4E3	Orpheovirus	1.9e-31	35.5
WP_000908982.1\|1203895_1206298_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_001284258.1\|1206468_1207407_-	ribonuclease HIII	NA	NA	NA	NA
WP_000191455.1\|1207776_1208043_+	cell division protein ZapA	NA	NA	NA	NA
WP_000234068.1\|1208043_1208565_+	CvpA family protein	NA	NA	NA	NA
WP_000161942.1\|1208637_1210350_+	DNA polymerase/3'-5' exonuclease PolX	A0A2H4UV14	Bodo_saltans_virus	8.9e-15	24.0
WP_001249285.1\|1210359_1212708_+	endonuclease MutS2	F2QAF8	Phaeocystis_pouchetii_virus	1.1e-15	25.3
WP_001018928.1\|1212880_1213195_+	thioredoxin	A0A1X9I9P5	Staphylococcus_phage	6.6e-25	46.6
WP_001788625.1\|1213257_1213353_-	hypothetical protein	NA	NA	NA	NA
WP_000390529.1\|1213518_1215300_+	excinuclease ABC subunit UvrC	NA	NA	NA	NA
WP_000079317.1\|1215623_1216238_+	succinate dehydrogenase cytochrome B558	NA	NA	NA	NA
WP_000818278.1\|1216289_1218056_+	succinate dehydrogenase flavoprotein subunit	NA	NA	NA	NA
WP_000139712.1\|1218055_1218871_+	succinate dehydrogenase iron-sulfur subunit	NA	NA	NA	NA
WP_001039659.1\|1219106_1219907_+	glutamate racemase	NA	NA	NA	NA
WP_000659317.1\|1219918_1220506_+	XTP/dITP diphosphatase	NA	NA	NA	NA
WP_000049484.1\|1220498_1221002_+	metallophosphoesterase	NA	NA	NA	NA
WP_001803346.1\|1221129_1221297_+	hypothetical protein	NA	NA	NA	NA
WP_000739209.1\|1221490_1221820_+	complement convertase inhibitor Ecb	NA	NA	NA	NA
WP_001791789.1\|1222136_1222229_-	hypothetical protein	NA	NA	NA	NA
WP_000739563.1\|1222188_1222590_-	formyl peptide receptor-like 1 inhibitory protein	NA	NA	NA	NA
WP_000584398.1\|1223260_1223767_+	hypothetical protein	NA	NA	NA	NA
WP_000791587.1\|1224025_1224523_+	complement convertase inhibitor Efb	NA	NA	NA	NA
WP_000669537.1\|1224676_1225027_+	complement inhibitor SCIN-B	NA	NA	NA	NA
WP_001032814.1\|1225847_1226033_-	hypothetical protein	NA	NA	NA	NA
WP_000231632.1\|1226654_1226888_-	hypothetical protein	NA	NA	NA	NA
WP_000848124.1\|1227364_1228324_-	beta-channel forming cytolysin	A0A2H4PQH7	Staphylococcus_phage	2.8e-34	29.9
WP_000195429.1\|1228588_1229761_+\|transposase	IS256-like element IS256 family transposase	A0A0N9STL0	Staphylococcus_phage	3.5e-135	100.0

DBSCAN-SWA_9

1760255 : 1769298

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1760255_1760774_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000594993.1\|1760795_1763069_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	1.2e-62	28.8
WP_000749795.1\|1763271_1765551_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1765825_1766086_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1766104_1767244_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019171.1\|1767266_1768292_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005767.1\|1768293_1769298_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_10

1902816 : 1981819

Staphylococcus_phage(93.22%)

protease,tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001050548.1\|1902816_1909377_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	2.0e-304	98.1
WP_000836465.1\|1909702_1910014_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	1.6e-52	100.0
WP_001108732.1\|1910035_1912450_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.2
WP_001025061.1\|1912740_1913922_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
WP_000526539.1\|1914031_1914985_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
WP_000764419.1\|1914981_1915545_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
WP_000757543.1\|1915664_1916066_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266096.1\|1917644_1918472_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_001790712.1\|1918474_1918594_-	hypothetical protein	NA	NA	NA	NA
WP_001196354.1\|1918705_1919707_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
WP_001008551.1\|1919828_1920293_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
WP_001159024.1\|1920305_1921487_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.6e-225	99.2
WP_000493892.1\|1921497_1922130_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.7e-112	99.5
WP_000384181.1\|1922136_1923168_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	4.8e-197	99.4
WP_001261678.1\|1923660_1925163_-	FAD-dependent oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	2.3e-30	100.0
WP_000221179.1\|1925685_1926000_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	2.0e-53	100.0
WP_000989121.1\|1925999_1927292_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	5.0e-228	99.5
WP_000163235.1\|1927309_1927705_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	6.3e-73	100.0
WP_001032833.1\|1927999_1928854_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1929129_1929354_-	hypothetical protein	NA	NA	NA	NA
WP_000671052.1\|1929552_1930023_+	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	1.0e-82	99.4
WP_001153742.1\|1930135_1930579_+	competence protein ComK	NA	NA	NA	NA
WP_001030465.1\|1930565_1931009_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	3.0e-55	85.0
WP_001168904.1\|1931304_1931940_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_001096494.1\|1932379_1933093_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091445.1\|1933352_1933655_+	hypothetical protein	NA	NA	NA	NA
WP_001200542.1\|1933910_1934276_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
WP_000623471.1\|1934272_1934626_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	1.0e-21	99.1
WP_000453322.1\|1936689_1937541_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	7.0e-154	97.8
WP_000366154.1\|1937752_1938661_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.2e-136	98.7
WP_000933822.1\|1938785_1939979_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000109906.1\|1940349_1941942_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	100.0
WP_000093392.1\|1942077_1942563_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	4.9e-19	35.4
WP_002868962.1\|1942937_1943684_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	7.1e-142	98.4
WP_000672014.1\|1943688_1944162_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	4.7e-83	98.1
WP_000718107.1\|1944227_1944485_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778523.1\|1944481_1945483_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	4.8e-186	97.6
WP_000348360.1\|1945487_1946966_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.0e-281	97.0
WP_011443643.1\|1947124_1947580_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	3.0e-79	98.6
WP_001795535.1\|1947882_1948533_+	calcium-binding protein	A0A2H4PQM8	Staphylococcus_phage	2.7e-44	88.4
WP_000070653.1\|1948613_1949609_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	7.1e-73	96.4
WP_000669046.1\|1949684_1950311_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	7.1e-79	82.7
WP_000627551.1\|1950351_1950696_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	6.3e-53	92.0
WP_000414205.1\|1950793_1951345_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	1.0e-20	94.1
WP_000494956.1\|1951562_1952204_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	2.6e-76	93.2
WP_000809857.1\|1952317_1952503_-	hypothetical protein	NA	NA	NA	NA
WP_000375476.1\|1952504_1952681_-	hypothetical protein	NA	NA	NA	NA
WP_000070811.1\|1952691_1953075_-	hypothetical protein	NA	NA	NA	NA
WP_001549059.1\|1953678_1953822_-\|transposase	transposase	A0A2H4PQU1	Staphylococcus_phage	6.4e-20	100.0
WP_144316852.1\|1954025_1954121_+	type I toxin-antitoxin system Fst family toxin	NA	NA	NA	NA
WP_001791893.1\|1954240_1954342_+	hypothetical protein	NA	NA	NA	NA
WP_002868972.1\|1954689_1955049_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000831215.1\|1955587_1959700_-	SMEK domain-containing protein	A0A2H4PQT3	Staphylococcus_phage	0.0e+00	99.9
WP_000072576.1\|1960549_1961749_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	5.5e-229	99.7
WP_011443644.1\|1961741_1963481_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	4.4e-288	99.4
WP_001791797.1\|1963461_1963596_-	hypothetical protein	NA	NA	NA	NA
WP_001038702.1\|1963660_1964380_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	1.0e-129	98.3
WP_001038867.1\|1964500_1965220_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	1.2e-130	99.2
WP_001039447.1\|1965277_1966000_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	2.4e-131	99.6
WP_001039435.1\|1966124_1966832_-\|protease	serine protease SplA	A0A2H4PQN3	Staphylococcus_phage	2.6e-130	100.0
WP_001092763.1\|1967795_1968362_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	3.3e-99	100.0
WP_000586140.1\|1968835_1969534_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	3.8e-113	94.4
WP_000581552.1\|1969530_1970292_-	lantibiotic immunity ABC transporter MutE/EpiE family permease subunit	A0A2H4PQH2	Staphylococcus_phage	4.4e-131	100.0
WP_001096791.1\|1970288_1970981_-	lantibiotic protection ABC transporter ATP-binding subunit	A0A2H4PQG7	Staphylococcus_phage	6.2e-124	100.0
WP_000691541.1\|1971003_1972377_-	S8 family serine peptidase	A0A2H4PQH1	Staphylococcus_phage	2.9e-258	100.0
WP_000504439.1\|1972386_1972905_-	enterotoxin	A0A2H4PQG9	Staphylococcus_phage	2.0e-95	100.0
WP_000566596.1\|1972920_1974165_-	lanthionine synthetase C family protein	A0A2H4PQH9	Staphylococcus_phage	5.1e-238	100.0
WP_001803290.1\|1974157_1975900_-	lantibiotic dehydratase	A0A2H4PQG8	Staphylococcus_phage	2.5e-259	54.1
WP_000416756.1\|1975964_1976108_-	gallidermin/nisin family lantibiotic	A0A2H4PQH4	Staphylococcus_phage	5.3e-14	80.9
WP_000195429.1\|1976817_1977990_-\|transposase	IS256-like element IS256 family transposase	A0A0N9STL0	Staphylococcus_phage	3.5e-135	100.0
WP_000416759.1\|1978175_1978319_-	gallidermin/nisin family lantibiotic	NA	NA	NA	NA
WP_000782464.1\|1978559_1979543_-	bi-component leukocidin LukED subunit D	A0A2H4PQH7	Staphylococcus_phage	2.3e-185	99.1
WP_000473590.1\|1979544_1980480_-	beta-channel forming cytolysin	A0A2H4PQI5	Staphylococcus_phage	5.1e-174	99.7
WP_001790220.1\|1981279_1981819_+	hypothetical protein	Q4ZCB9	Staphylococcus_virus	2.0e-61	76.8

DBSCAN-SWA_11

2065707 : 2163717

117

Staphylococcus_phage(91.25%)

portal,integrase,capsid,protease,tRNA,head,holin,terminase,tail

attL 2127594:2127611|attR 2153641:2153658

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000027928.1\|2065707_2067165_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_000170162.1\|2067166_2067469_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_000957012.1\|2067835_2069374_+	sodium/proline symporter PutP	NA	NA	NA	NA
WP_000831698.1\|2069462_2070662_-	CamS family sex pheromone protein	NA	NA	NA	NA
WP_000774565.1\|2070674_2072678_-	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	5.8e-114	36.1
WP_000992921.1\|2072681_2074874_-	DNA helicase PcrA	A7KV33	Bacillus_phage	1.0e-135	42.2
WP_000272068.1\|2074870_2075563_-	heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
WP_001165363.1\|2075734_2076037_-	hypothetical protein	NA	NA	NA	NA
WP_000572878.1\|2076145_2077441_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.6e-16	32.9
WP_000827748.1\|2078301_2079468_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434933.1\|2079498_2079825_+	staphostatin A	NA	NA	NA	NA
WP_000669862.1\|2080116_2080290_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011542.1\|2080270_2080873_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040873.1\|2081143_2081965_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	1.8e-69	52.7
WP_000284431.1\|2081957_2083427_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	4.5e-108	45.1
WP_000897635.1\|2083610_2084687_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177817.1\|2084706_2085501_+	prephenate dehydratase	NA	NA	NA	NA
WP_001802312.1\|2085572_2085680_+	hypothetical protein	NA	NA	NA	NA
WP_000323161.1\|2085690_2087253_-	SLC13 family permease	NA	NA	NA	NA
WP_000275730.1\|2087457_2088555_-	pectate lyase	U5PWM6	Bacillus_phage	1.9e-47	34.6
WP_000149686.1\|2088926_2089487_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|2089539_2090469_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001790680.1\|2090663_2090837_-	hypothetical protein	NA	NA	NA	NA
WP_001021214.1\|2090888_2092268_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_023180182.1\|2092387_2093416_-	lactonase family protein	NA	NA	NA	NA
WP_000205106.1\|2093684_2094086_+	YolD-like family protein	U3PG23	Staphylococcus_phage	6.0e-23	42.9
WP_000267034.1\|2094658_2094832_-	hypothetical protein	NA	NA	NA	NA
WP_001188077.1\|2095282_2096323_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000713060.1\|2096379_2097222_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001033971.1\|2097218_2097776_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966288.1\|2097835_2098360_-	membrane protein	NA	NA	NA	NA
WP_000182842.1\|2098480_2099044_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221651.1\|2099109_2099850_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_000763048.1\|2099849_2100722_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_000645727.1\|2100718_2101399_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991302.1\|2101399_2102296_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	1.1e-16	30.2
WP_000691584.1\|2102292_2102673_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681968.1\|2102936_2103113_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|2103355_2103454_-	hypothetical protein	NA	NA	NA	NA
WP_001068542.1\|2103653_2104940_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_001549158.1\|2105564_2107319_-	MAP domain-containing protein	NA	NA	NA	NA
WP_000669789.1\|2108276_2108456_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	2.2e-25	100.0
WP_001791826.1\|2108766_2109027_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000702262.1\|2109079_2109430_-	complement inhibitor SCIN-A	A7TWS0	Staphylococcus_phage	7.5e-54	100.0
WP_096784214.1\|2109938_2110397_-	amidase	R9QTN8	Staphylococcus_phage	2.4e-84	98.7
WP_000920041.1\|2110925_2111417_-	staphylokinase	A7TWR8	Staphylococcus_phage	8.0e-86	100.0
WP_000861038.1\|2111607_2112363_-	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
WP_000611512.1\|2112374_2112629_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_072482930.1\|2112840_2113017_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	3.8e-22	96.6
WP_000750412.1\|2113125_2113899_-	staphylococcal enterotoxin type A	A0A1X9H080	Staphylococcus_phage	1.1e-145	100.0
WP_000340977.1\|2114271_2114646_-	hypothetical protein	G4KNR3	Staphylococcus_phage	3.3e-39	100.0
WP_001262621.1\|2114701_2114989_-	hypothetical protein	A0A1X9H0N7	Staphylococcus_phage	7.6e-44	100.0
WP_001000059.1\|2115034_2115187_-	hypothetical protein	A0A1W6JPL6	Staphylococcus_phage	1.7e-18	98.0
WP_000582173.1\|2115179_2118962_-	hypothetical protein	A0A1X9H096	Staphylococcus_phage	0.0e+00	99.7
WP_000567408.1\|2118977_2120462_-\|tail	phage tail protein	A0A2I6PDJ0	Staphylococcus_phage	1.2e-297	100.0
WP_001795393.1\|2120458_2124988_-\|tail	phage tail tape measure protein	A0A1X9H084	Staphylococcus_phage	0.0e+00	100.0
WP_001789580.1\|2125044_2125206_-	hypothetical protein	A0A0H3U330	Staphylococcus_phage	1.6e-22	100.0
WP_001096355.1\|2125232_2125583_-	hypothetical protein	G4KNQ8	Staphylococcus_phage	7.8e-59	100.0
WP_072050172.1\|2125632_2125857_-	hypothetical protein	A0A075LYE8	Staphylococcus_phage	8.8e-32	98.6
WP_000268741.1\|2125898_2126543_-\|tail	phage tail protein	W5R9H4	Staphylococcus_phage	6.5e-120	100.0
WP_000565498.1\|2126543_2126951_-	hypothetical protein	G4KNQ6	Staphylococcus_phage	7.1e-72	100.0
WP_000114225.1\|2126947_2127352_-	hypothetical protein	A0A2I6PDJ6	Staphylococcus_phage	4.3e-69	100.0
WP_000755150.1\|2127348_2127711_-\|head,tail	head-tail adaptor protein	G4KNQ4	Staphylococcus_phage	4.4e-65	100.0
2127594:2127611	attL	NA	NA	NA	NA
WP_000150936.1\|2127694_2127979_-\|head,tail	phage head-tail adapter protein	A0A2I6PDJ5	Staphylococcus_phage	2.3e-45	100.0
WP_000238236.1\|2127968_2128253_-	hypothetical protein	A0A2I6PDJ3	Staphylococcus_phage	1.8e-45	100.0
WP_000154555.1\|2128272_2129418_-\|capsid	phage major capsid protein	A0A1X9H072	Staphylococcus_phage	5.6e-215	100.0
WP_000861914.1\|2129441_2130179_-\|protease	Clp protease ClpP	C8CH20	Staphylococcus_phage	2.3e-129	100.0
WP_000025274.1\|2130162_2131350_-\|portal	phage portal protein	A0A2I6PDI1	Staphylococcus_phage	1.0e-219	100.0
WP_000625088.1\|2131365_2133027_-\|terminase	terminase large subunit	A0A2I6PDJ8	Staphylococcus_phage	0.0e+00	100.0
WP_000402904.1\|2133023_2133368_-	hypothetical protein	G4KNP9	Staphylococcus_phage	9.4e-57	100.0
WP_000988336.1\|2133498_2133798_-	HNH endonuclease	A0EWY8	Staphylococcus_phage	4.6e-52	100.0
WP_000590126.1\|2134029_2134446_-	hypothetical protein	A0A1X9H0U8	Staphylococcus_phage	2.9e-76	100.0
WP_000265039.1\|2134473_2134674_-	DUF1514 family protein	R9QT57	Staphylococcus_phage	1.4e-28	98.5
WP_000595265.1\|2134673_2134823_-	transcriptional activator RinB	A0A1W6JPZ2	Staphylococcus_phage	4.8e-18	100.0
WP_000592207.1\|2134819_2135206_-	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
WP_000195820.1\|2135202_2135409_-	DUF1381 domain-containing protein	A0A1X9H0C2	Staphylococcus_phage	1.3e-21	100.0
WP_001066444.1\|2135445_2135982_-	hypothetical protein	A0A1X9H0S5	Staphylococcus_phage	1.4e-96	100.0
WP_000197967.1\|2135974_2136385_-	hypothetical protein	C8CH13	Staphylococcus_phage	2.3e-70	100.0
WP_001065024.1\|2136381_2136867_-	DUF1024 family protein	A0A1X9H0D4	Staphylococcus_phage	3.6e-70	93.4
WP_001105604.1\|2136859_2137144_-	hypothetical protein	S4V9L1	Staphylococcus_phage	2.1e-46	97.9
WP_000982711.1\|2137140_2137590_-	hypothetical protein	A0A2I6PDH2	Staphylococcus_phage	2.1e-80	99.3
WP_000178986.1\|2137654_2137903_-	hypothetical protein	A0A0K1LL46	Staphylococcus_phage	1.2e-40	97.6
WP_000111491.1\|2137899_2138157_-	DUF3310 domain-containing protein	A0A1X9H067	Staphylococcus_phage	6.3e-42	98.8
WP_000401969.1\|2138541_2138946_-	RusA family crossover junction endodeoxyribonuclease	A0A075M042	Staphylococcus_phage	8.4e-73	100.0
WP_000338528.1\|2138954_2139173_-	hypothetical protein	A0A1P8L6E4	Staphylococcus_phage	1.4e-37	100.0
WP_000148333.1\|2139179_2140073_-	DnaD domain-containing protein	A0A1P8L6F0	Staphylococcus_phage	3.2e-141	100.0
WP_000934759.1\|2140102_2140573_-	single-stranded DNA-binding protein	A0A1P8L6D9	Staphylococcus_phage	5.7e-81	100.0
WP_064135358.1\|2140573_2141191_-	MBL fold metallo-hydrolase	A0A1P8L6F7	Staphylococcus_phage	1.2e-86	100.0
WP_000180598.1\|2141271_2142192_-	recombinase	A0A1P8L6F6	Staphylococcus_phage	8.6e-166	99.7
WP_000700555.1\|2142193_2144137_-	AAA family ATPase	S4V9K6	Staphylococcus_phage	0.0e+00	100.0
WP_001205732.1\|2144145_2144409_-	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	7.7e-43	100.0
WP_001814567.1\|2144417_2144678_-	DUF1108 family protein	D2JGJ8	Staphylococcus_phage	5.8e-43	100.0
WP_000138304.1\|2144658_2144988_-	hypothetical protein	D2JGJ7	Staphylococcus_phage	1.4e-33	100.0
WP_000066017.1\|2145077_2145239_-	DUF1270 domain-containing protein	D2JGJ6	Staphylococcus_phage	4.3e-20	100.0
WP_001120197.1\|2145235_2145556_-	DUF771 domain-containing protein	A0A2I6PDH6	Staphylococcus_phage	1.5e-56	100.0
WP_000275058.1\|2145614_2146247_+	hypothetical protein	A7TW95	Staphylococcus_phage	1.5e-113	100.0
WP_000939496.1\|2146261_2146402_-	hypothetical protein	A0A2I6PDG0	Staphylococcus_phage	1.9e-16	100.0
WP_001148861.1\|2146432_2146630_-	hypothetical protein	A0A1W6JPV3	Staphylococcus_phage	1.2e-24	100.0
WP_001148653.1\|2146645_2147395_-	antirepressor	O80074	Staphylococcus_phage	2.0e-136	100.0
WP_000180411.1\|2147445_2147775_+	hypothetical protein	A0A0H3U4Z1	Staphylococcus_phage	4.6e-53	100.0
WP_001025404.1\|2147763_2147979_-	DUF2829 domain-containing protein	A0A0H3U4C7	Staphylococcus_phage	4.8e-35	100.0
WP_000854072.1\|2147994_2148258_-	helix-turn-helix transcriptional regulator	A0A2I6PF09	Staphylococcus_phage	7.2e-41	100.0
WP_001801500.1\|2148254_2148428_-	hypothetical protein	NA	NA	NA	NA
WP_001031454.1\|2148390_2149104_+	helix-turn-helix transcriptional regulator	M9NUL0	Staphylococcus_phage	1.2e-130	100.0
WP_000759682.1\|2149119_2150052_+	ATP-dependent helicase	A0A2I6PEZ7	Staphylococcus_phage	5.7e-173	100.0
WP_000591749.1\|2150057_2150399_+	hypothetical protein	A0A2I6PF04	Staphylococcus_phage	4.6e-56	100.0
WP_000705248.1\|2150602_2150785_+	hypothetical protein	M9NSW6	Staphylococcus_phage	4.1e-27	100.0
WP_000825947.1\|2150884_2151349_+	hypothetical protein	A0EWV3	Staphylococcus_phage	1.1e-28	100.0
WP_000857191.1\|2151407_2152445_+\|integrase	site-specific integrase	A0EWV2	Staphylococcus_phage	9.1e-180	100.0
WP_000595324.1\|2153563_2154580_-	bi-component leukocidin LukGH subunit G	A0A2I6PER8	Staphylococcus_phage	1.1e-25	29.0
2153641:2153658	attR	NA	NA	NA	NA
WP_000791407.1\|2154601_2155657_-	bi-component leukocidin LukGH subunit H	A0A1X9IGW5	Staphylococcus_phage	2.8e-35	34.3
WP_000206638.1\|2156091_2157315_+	ArgE/DapE family deacylase	NA	NA	NA	NA
WP_000825510.1\|2158591_2159503_-	iron-hydroxamate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001045079.1\|2159663_2160971_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000022887.1\|2161823_2162267_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_001797573.1\|2162431_2162809_-	hypothetical protein	NA	NA	NA	NA
WP_001293058.1\|2163126_2163717_-\|terminase	terminase small subunit	Q4ZE85	Staphylococcus_phage	1.1e-97	95.8

DBSCAN-SWA_12

2178588 : 2252143

Staphylococcus_phage(93.68%)

integrase,transposase

attL 2207554:2207613|attR 2245844:2247168

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001052278.1\|2178588_2179839_-	ammonium transporter	H8ZJB2	Ostreococcus_tauri_virus	7.6e-40	31.2
WP_000581077.1\|2180045_2180270_-	sulfurtransferase TusA family protein	NA	NA	NA	NA
WP_001260014.1\|2181189_2182728_-	recombinase family protein	A0A0N9RZT8	Staphylococcus_phage	5.3e-277	100.0
WP_001281071.1\|2182717_2183299_-	DNA-binding protein	A0A0N9SK69	Staphylococcus_phage	1.6e-101	97.9
WP_001083475.1\|2184079_2184472_-	hypothetical protein	A0A0N9RRM7	Staphylococcus_phage	2.0e-63	96.9
WP_000487602.1\|2184473_2185220_-	NTP pyrophosphohydrolase	A0A0N9SIY2	Staphylococcus_phage	5.3e-121	88.7
WP_000414358.1\|2185232_2185472_-	hypothetical protein	A0A0N9S8B1	Staphylococcus_phage	8.2e-36	94.9
WP_001006074.1\|2185487_2185736_-	thioredoxin family protein	A0A0N9SGY3	Staphylococcus_phage	4.0e-41	98.8
WP_000602136.1\|2185776_2186379_-	AAA family ATPase	A0A0N9RTZ3	Staphylococcus_phage	9.8e-110	99.0
WP_000196388.1\|2186406_2187429_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A0N9SK77	Staphylococcus_phage	4.3e-198	99.7
WP_071813268.1\|2187473_2187830_-	ribonucleoside-diphosphate reductase	A0A2H4J2N6	uncultured_Caudovirales_phage	5.9e-38	60.2
WP_031265563.1\|2188143_2191020_-	intein-containing class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A0N7GFG8	Staphylococcus_phage	0.0e+00	99.4
WP_000509886.1\|2191074_2191521_-	hypothetical protein	A0A0N9STF9	Staphylococcus_phage	5.1e-71	93.2
WP_001807395.1\|2191520_2191934_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A0N9RZU5	Staphylococcus_phage	8.9e-70	97.8
WP_001145748.1\|2192134_2192836_-	hypothetical protein	A0A0N9RRN5	Staphylococcus_phage	1.8e-123	96.6
WP_000389908.1\|2192847_2193357_-	siphovirus Gp157 family protein	A0A0N9SIY9	Staphylococcus_phage	7.3e-82	97.0
WP_000729421.1\|2193486_2194089_-	hypothetical protein	A0A0N9S8C0	Staphylococcus_phage	1.8e-55	89.2
WP_000824898.1\|2194088_2194319_-	hypothetical protein	A0A0N9SGZ7	Staphylococcus_phage	1.8e-32	100.0
WP_000356944.1\|2194332_2194515_-	hypothetical protein	A0A0N7GFG9	Staphylococcus_phage	3.1e-27	100.0
WP_000792728.1\|2194517_2194871_-	hypothetical protein	A0A0N9RU04	Staphylococcus_phage	1.2e-59	100.0
WP_000598580.1\|2194903_2195902_-	DNA cytosine methyltransferase	A0A0N9SK84	Staphylococcus_phage	3.1e-193	99.7
WP_001108802.1\|2195916_2196603_-	methyltransferase domain-containing protein	A0A0N9SHZ9	Staphylococcus_phage	4.0e-123	96.1
WP_000460098.1\|2196592_2196784_-	hypothetical protein	A0A0N9STH2	Staphylococcus_phage	5.2e-33	96.8
WP_000416627.1\|2196776_2197388_-	nucleoside 2-deoxyribosyltransferase	A0A0N9RZV9	Staphylococcus_phage	3.8e-109	98.0
WP_000404790.1\|2197350_2197581_-	hypothetical protein	A0A0N9SKA8	Staphylococcus_phage	8.2e-25	96.6
WP_000865652.1\|2197580_2197832_-	hypothetical protein	A0A0N9RRP5	Staphylococcus_phage	3.8e-39	100.0
WP_000937287.1\|2197854_2198160_-	hypothetical protein	A0A0N7GFH0	Staphylococcus_phage	1.8e-51	100.0
WP_001031085.1\|2198140_2198428_-	hypothetical protein	A0A0N9SIZ8	Staphylococcus_phage	2.3e-40	92.6
WP_000041332.1\|2198420_2198687_-	hypothetical protein	A0A0N9S8D1	Staphylococcus_phage	4.3e-41	97.7
WP_001098622.1\|2198986_2199370_-	DUF3139 domain-containing protein	A0A0N9RU12	Staphylococcus_phage	2.6e-47	94.7
WP_001157078.1\|2199456_2200755_-	ATP-dependent DNA ligase	A0A0N9SK95	Staphylococcus_phage	2.6e-240	98.1
WP_000866402.1\|2200764_2201079_-	hypothetical protein	A0A0N9SI08	Staphylococcus_phage	4.7e-39	81.7
WP_001215077.1\|2201217_2201598_-	hypothetical protein	A0A0N9STI1	Staphylococcus_phage	8.8e-48	96.0
WP_000350441.1\|2201710_2204197_-	hypothetical protein	A0A0N7GFH1	Staphylococcus_phage	0.0e+00	99.5
WP_000335153.1\|2204541_2205978_-	PHP domain-containing protein	A0A0N9SKC7	Staphylococcus_phage	2.7e-275	98.3
WP_000601657.1\|2205990_2206365_-	hypothetical protein	A0A0N9RRQ3	Staphylococcus_phage	1.3e-59	95.2
WP_000154133.1\|2206534_2207029_+	hypothetical protein	A0A0N9SJ02	Staphylococcus_phage	1.0e-64	96.4
2207554:2207613	attL	NA	NA	NA	NA
WP_000195429.1\|2207655_2208828_+\|transposase	IS256-like element IS256 family transposase	A0A0N9STL0	Staphylococcus_phage	3.5e-135	100.0
WP_001028141.1\|2208964_2210404_-	bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia	A0A0N9SKF6	Staphylococcus_phage	8.5e-285	100.0
WP_000393259.1\|2210404_2210797_-	GNAT family N-acetyltransferase	A0A0N7GFH7	Staphylococcus_phage	6.9e-72	100.0
WP_072387101.1\|2212417_2212825_-	WYL domain-containing protein	A0A1B0RXM3	Streptococcus_phage	1.1e-59	98.3
WP_001096887.1\|2213644_2214439_-	aminoglycoside O-phosphotransferase APH(3')-IIIa	E4ZFP6	Streptococcus_phage	2.3e-154	100.0
WP_002505594.1\|2214946_2215198_-	hypothetical protein	A0A1B0RXL7	Streptococcus_phage	2.5e-27	98.7
WP_001043218.1\|2216044_2216767_-	hypothetical protein	A0A0N7GFH2	Staphylococcus_phage	1.4e-89	98.3
WP_000686449.1\|2216875_2217676_-	serine/threonine protein phosphatase	A0A0N9SKA2	Staphylococcus_phage	4.0e-151	100.0
WP_000280790.1\|2217679_2218174_-	hypothetical protein	A0A0N9SI15	Staphylococcus_phage	5.2e-85	98.8
WP_000755772.1\|2218230_2218500_-	hypothetical protein	A0A0N9STI7	Staphylococcus_phage	6.9e-39	100.0
WP_032605691.1\|2218483_2218675_-	hypothetical protein	A0A0N9RZX7	Staphylococcus_phage	8.6e-20	82.5
WP_001179607.1\|2218976_2219372_-	type II toxin-antitoxin system death-on-curing family toxin	A0A0N9SKD8	Staphylococcus_phage	6.7e-59	90.1
WP_000258939.1\|2219371_2219602_-	addiction module antitoxin	A0A0N9RRQ9	Staphylococcus_phage	6.5e-30	85.5
WP_000639078.1\|2219777_2220299_-	hypothetical protein	A0A0N9SJ06	Staphylococcus_phage	1.9e-93	94.2
WP_000411528.1\|2220298_2220949_-	hypothetical protein	A0A0N7GFH3	Staphylococcus_phage	3.5e-113	96.3
WP_001807410.1\|2220948_2221266_-	hypothetical protein	A0A0N9S8E9	Staphylococcus_phage	1.2e-42	82.7
WP_000197304.1\|2221258_2221984_-	serine/threonine protein phosphatase	A0A0N9SH20	Staphylococcus_phage	4.8e-135	95.9
WP_000829423.1\|2221983_2222205_-	hypothetical protein	A0A0N9RU28	Staphylococcus_phage	5.5e-34	95.9
WP_129760514.1\|2222224_2222410_-	hypothetical protein	A0A0N9SKB9	Staphylococcus_phage	4.0e-22	89.7
WP_000858632.1\|2222393_2222936_-	hypothetical protein	A0A0N9SI25	Staphylococcus_phage	7.2e-96	97.2
WP_000691100.1\|2222950_2223223_-	hypothetical protein	A0A0N9STJ5	Staphylococcus_phage	6.7e-42	96.7
WP_000792995.1\|2223248_2223404_-	transcriptional regulator	A0A0N9RZY5	Staphylococcus_phage	2.2e-18	98.0
WP_001187008.1\|2223700_2223886_-	hypothetical protein	A0A0N9SKE7	Staphylococcus_phage	1.5e-24	100.0
WP_000401832.1\|2223870_2224050_-	hypothetical protein	A0A0N9RRR6	Staphylococcus_phage	1.1e-21	91.5
WP_000833764.1\|2224063_2224546_-	hypothetical protein	A0A0N9SJ15	Staphylococcus_phage	8.8e-69	94.3
WP_000924986.1\|2224547_2224736_-	hypothetical protein	A0A0N9S8F9	Staphylococcus_phage	4.5e-29	95.2
WP_000867237.1\|2224741_2224933_-	hypothetical protein	A0A0N9SH33	Staphylococcus_phage	6.2e-18	88.0
WP_000742009.1\|2224929_2225157_-	hypothetical protein	NA	NA	NA	NA
WP_000403510.1\|2225161_2225428_-	hypothetical protein	A0A0N9RU37	Staphylococcus_phage	3.6e-40	95.5
WP_000800820.1\|2225417_2225621_-	hypothetical protein	A0A1W6JP82	Staphylococcus_phage	9.2e-20	72.3
WP_001041170.1\|2225639_2225891_-	hypothetical protein	NA	NA	NA	NA
WP_000042824.1\|2226164_2226398_-	hypothetical protein	A0A0N7GFH5	Staphylococcus_phage	2.6e-34	97.4
WP_000359469.1\|2226419_2226644_-	hypothetical protein	A0A0N9SI40	Staphylococcus_phage	2.0e-31	100.0
WP_000862563.1\|2226649_2226997_-	nuclease	A0A0N9STK3	Staphylococcus_phage	4.4e-62	100.0
WP_000937215.1\|2226993_2227404_-	hypothetical protein	A0A0N9RZZ6	Staphylococcus_phage	1.1e-72	97.1
WP_000312937.1\|2227443_2227707_-	hypothetical protein	A0A0N9SKF2	Staphylococcus_phage	6.9e-44	100.0
WP_000239839.1\|2227709_2228081_-	hypothetical protein	A0A2H4JFL4	uncultured_Caudovirales_phage	3.9e-16	38.7
WP_048666632.1\|2228083_2228392_-	hypothetical protein	A0A0N9RRS4	Staphylococcus_phage	1.3e-41	85.3
WP_000022947.1\|2228684_2228960_-	hypothetical protein	A0A0N7GFH6	Staphylococcus_phage	2.0e-41	92.3
WP_000404899.1\|2228972_2229170_-	hypothetical protein	A0A0N9SH39	Staphylococcus_phage	3.2e-25	92.3
WP_000542668.1\|2229180_2230218_-	hypothetical protein	A0A0N9RU46	Staphylococcus_phage	8.8e-191	97.7
WP_000389289.1\|2230474_2231212_-	ribonuclease Z	A0A0N9RZK9	Staphylococcus_phage	7.0e-134	99.6
WP_000865239.1\|2231405_2233172_-	single-stranded DNA-binding protein	A0A0N9SK20	Staphylococcus_phage	0.0e+00	99.7
WP_000459730.1\|2233174_2234287_-	hypothetical protein	A0A0N9RRG7	Staphylococcus_phage	1.8e-218	99.7
WP_001048214.1\|2234303_2235836_-	helicase DnaB	A0A0N9SIU7	Staphylococcus_phage	2.4e-293	99.0
WP_023180191.1\|2235857_2236376_-	hypothetical protein	A0A0N9S850	Staphylococcus_phage	5.1e-91	98.8
WP_000050755.1\|2236452_2237421_-	ATP-binding protein	A0A0N9SGS5	Staphylococcus_phage	1.0e-180	99.4
WP_000852323.1\|2237543_2238503_-	hypothetical protein	A0A0N7GFF9	Staphylococcus_phage	6.7e-169	100.0
WP_000668931.1\|2238546_2239227_-	hypothetical protein	A0A0N9RTS7	Staphylococcus_phage	2.0e-127	100.0
WP_000364656.1\|2239244_2239733_-	hypothetical protein	A0A0N9SK25	Staphylococcus_phage	2.3e-53	99.4
WP_000035084.1\|2239748_2239997_-	hypothetical protein	A0A0N9SHT9	Staphylococcus_phage	1.7e-39	97.6
WP_001110387.1\|2240155_2241160_-	hypothetical protein	A0A0N9ST56	Staphylococcus_phage	1.0e-183	99.4
WP_001030860.1\|2241171_2242452_-	hypothetical protein	A0A0N9RZM2	Staphylococcus_phage	1.1e-235	99.8
WP_000993078.1\|2242750_2243794_-\|integrase	site-specific integrase	A0A0N9SK33	Staphylococcus_phage	8.0e-192	98.6
WP_000759940.1\|2244485_2244914_-	hypothetical protein	A0A0N9RRH5	Staphylococcus_phage	9.5e-75	98.6
WP_000725702.1\|2244991_2245513_-	hypothetical protein	A0A0N7GFG0	Staphylococcus_phage	1.7e-89	98.3
WP_000228097.1\|2245512_2245776_-	hypothetical protein	A0A0N9SIV3	Staphylococcus_phage	4.3e-38	89.7
WP_000195429.1\|2245945_2247118_+\|transposase	IS256-like element IS256 family transposase	A0A0N9STL0	Staphylococcus_phage	3.5e-135	100.0
WP_000856958.1\|2247253_2248756_+	N-acetylmuramoyl-L-alanine amidase	A0A0N9SGX6	Staphylococcus_phage	9.8e-276	95.4
2245844:2247168	attR	NA	NA	NA	NA
WP_000348472.1\|2249726_2251376_-	hypothetical protein	A0A0N9SHY1	Staphylococcus_phage	6.1e-312	94.5
WP_000748898.1\|2251528_2252143_-	LPXTG cell wall anchor domain-containing protein	A0A0N9STB7	Staphylococcus_phage	6.8e-74	96.6

Anti-CRISPR protein detection

Acr_ID: NC_022604.1|WP_000856472.1|1154909_1155146_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_022604.1|WP_000856472.1|1154909_1155146_-|hypothetical-protein

1154909_1155146_-

78 aa aa

HTH_XRE

Identity	Hit_domain_coverage
0.42592592592592593	0.9310344827586207

1148617-1229761

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_022604_7	Orphan	7.1\|1225412\|35\|NC_022604\|CRT	1225412-1225446	35	1225356-1225390	1
NC_022604_7	Orphan	7.3\|1225525\|35\|NC_022604\|CRT	1225525-1225559	35	1225356-1225390	1
NC_022604_7	Orphan	7.6\|1225540\|20\|NC_022604\|PILER-CR	1225540-1225559	20	1225371-1225390	1

1. spacer 7.1|1225412|35|NC_022604|CRT matches to NC_022604 position: 1225356-1225390, mismatch: 1

cagagagaaataggatcaccaatttcaacagacaa	CRISPR spacer
cagagagaaataggatcaccaattccaacagacaa	Protospacer
************************.**********

2. spacer 7.3|1225525|35|NC_022604|CRT matches to NC_022604 position: 1225356-1225390, mismatch: 1

cagagagaaataggatcaccaattccaacaaacaa	CRISPR spacer
cagagagaaataggatcaccaattccaacagacaa	Protospacer
******************************.****

3. spacer 7.6|1225540|20|NC_022604|PILER-CR matches to NC_022604 position: 1225371-1225390, mismatch: 1

tcaccaattccaacaaacaa	CRISPR spacer
tcaccaattccaacagacaa	Protospacer
***************.****

2. NC_022610

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

18881 : 27214

Streptococcus_phage(28.57%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001105968.1\|18881_19556_+\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	9.9e-127	98.7
WP_000003264.1\|19790_21974_-	cadmium-translocating P-type ATPase CadA	E4ZFI9	Streptococcus_phage	8.1e-255	64.0
WP_000726007.1\|21966_22335_-	Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory transcriptional repressor CadC	E4ZFI8	Streptococcus_phage	4.2e-55	85.2
WP_000690625.1\|22706_23285_+	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	4.2e-41	51.1
WP_000583528.1\|23410_24019_+	recombinase family protein	G8I4U3	Mycobacterium_phage	1.0e-13	30.2
WP_001049146.1\|24264_24603_+	hypothetical protein	NA	NA	NA	NA
WP_000797248.1\|24607_24793_+	helix-turn-helix transcriptional regulator	A0A142LP09	Marinitoga_camini_virus	9.9e-05	37.9
WP_001807342.1\|24925_25492_-	multidrug-binding transcriptional regulator QacR	NA	NA	NA	NA
WP_000622774.1\|25669_27214_+	QacA/B family quaternary ammonium compound efflux MFS transporter	A0A0M3UL24	Mycobacterium_phage	3.3e-32	26.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022604

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

2. NC_022610

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection