| NC_021880.1|WP_020849513.1|1452192_1453701_+|murein-biosynthesis-integral-membrane-protein-MurJ |
gnl|CDD|240528 |
cd13123, MATE_MurJ_like, MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
|
1.55195e-120 |
| NC_021880.1|WP_011451396.1|1465261_1465870_-|ABC-transporter-substrate-binding-protein |
gnl|CDD|377516 |
pfam05494, MlaC, MlaC protein. MlaC is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. This family of proteins is involved in toluene tolerance, which is mediated by increased cell membrane rigidity resulting from changes in fatty acid and phospholipid compositions, exclusion of toluene from the cell membrane, and removal of intracellular toluene by degradation. Many proteins are involved in these processes.
|
1.00225e-20 |
| NC_021880.1|WP_011451381.1|1451274_1452108_-|prolipoprotein-diacylglyceryl-transferase |
gnl|CDD|234599 |
PRK00052, PRK00052, prolipoprotein diacylglyceryl transferase; Reviewed.
|
3.58729e-98 |
| NC_021880.1|WP_011451402.1|1473836_1475141_-|TrbI/VirB10-family-protein |
gnl|CDD|319755 |
cd16429, VirB10, VirB10 forms part of core complex in Type IV secretion system (T4SS). This family contains VirB10, a component of the type IV secretion system (T4SS), including homologs TrbI, TraF, TrwE and TraL. T4S system is employed by pathogenic bacteria to export virulence DNAs and/or proteins directly from the bacterial cytoplasm into the host cell. It forms a large multiprotein complex consisting of 12 proteins termed VirB1-11 and VirD4. VirB10, interacts with VirB7 and VirB9, forming the membrane-spanning 'core complex' (CC), around which all other components assemble. The CC is inserted in both, the outer and inner membranes, playing a fundamental role as a scaffold for the rest of the T4SS components and actively participating in T4S substrate transfer through the bacterial envelope via conformational changes regulating channel opening and closing. TrwE in R33 plasmid has been shown to be anchored to the inner membrane and its C-terminal is necessary for conjugation; the transmembrane domains of TrwB and TrwE are involved in TrwB-TrwE interactions. TraF protein of the RP4 plasmid is involved in circularization of pilin subunits of P-type pili. In gonococcal genetic island (GGI) of Neisseria gonorrhoeae, T4SS encodes TrbI and circularization occurs via a covalent intermediate between the C terminus of putative pilin protein TraA and TrbI.
|
1.26639e-57 |
| NC_021880.1|WP_020849514.1|1454977_1455355_+|hypothetical-protein |
gnl|CDD|173412 |
PTZ00121, PTZ00121, MAEBL; Provisional.
|
1.22801e-06 |
| NC_021880.1|WP_011451400.1|1470517_1472740_-|type-IV-secretory-system-conjugative-DNA-transfer-family-protein |
gnl|CDD|237549 |
PRK13897, PRK13897, type IV secretion system component VirD4; Provisional.
|
0 |
| NC_021880.1|WP_011451401.1|1472791_1473790_-|P-type-DNA-transfer-ATPase-VirB11 |
gnl|CDD|184381 |
PRK13900, PRK13900, type IV secretion system ATPase VirB11; Provisional.
|
0 |
| NC_021880.1|WP_020849195.1|1466965_1467631_-|heme-exporter-protein-CcmB |
gnl|CDD|225260 |
COG2386, CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones].
|
5.08676e-10 |
| NC_021880.1|WP_021799171.1|1467738_1468170_+|TraR/DksA-C4-type-zinc-finger-protein |
gnl|CDD|274124 |
TIGR02420, RNA_polymerase-binding_transcription_factor_DksA, RNA polymerase-binding protein DksA. The model that is the basis for this family describes a small, pleiotropic protein, DksA (DnaK suppressor A), originally named as a multicopy suppressor of temperature sensitivity of dnaKJ mutants. DksA mutants are defective in quorum sensing, virulence, etc. DksA is now understood to bind RNA polymerase directly and modulate its response to small molecules to control the level of transcription of rRNA. Nearly all members of this family are in the Proteobacteria. Whether the closest homologs outside the Proteobacteria function equivalently is unknown. The low value set for the noise cutoff allows identification of possible DksA proteins from outside the proteobacteria. TIGR02419 describes a closely related family of short sequences usually found in prophage regions of proteobacterial genomes or in known phage. [Transcription, Transcription factors, Regulatory functions, Small molecule interactions].
|
2.36487e-27 |
| NC_021880.1|WP_021799173.1|1475164_1476007_-|P-type-conjugative-transfer-protein-VirB9 |
gnl|CDD|274296 |
TIGR02781, Protein_virB9, P-type conjugative transfer protein VirB9. The VirB9 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in a type IV secretion system . VirB9 is a homolog of the F-type conjugative transfer system TraK protein (which is believed to be an outer membrane pore-forming secretin, TIGR02756) as well as the Ti system TrbG protein. [Cellular processes, Conjugation].
|
2.14694e-81 |
| NC_021880.1|WP_020849519.1|1469179_1470031_-|P44/Msp2-family-outer-membrane-protein |
gnl|CDD|366729 |
pfam01617, Surface_Ag_2, Surface antigen. This family includes a number of bacterial surface antigens expressed on the surface of pathogens.
|
2.37532e-12 |
| NC_021880.1|WP_011451394.1|1463751_1464891_-|P44/Msp2-family-outer-membrane-protein |
gnl|CDD|366729 |
pfam01617, Surface_Ag_2, Surface antigen. This family includes a number of bacterial surface antigens expressed on the surface of pathogens.
|
1.4695e-31 |
| NC_021880.1|WP_044104407.1|1465946_1466840_-|cation-transporter |
gnl|CDD|235130 |
PRK03557, PRK03557, CDF family zinc transporter ZitB.
|
1.63451e-81 |
