CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016894	Acetobacterium woodii DSM 1030, complete sequence	3 crisprs	csa3,WYL,RT,DinG,DEDDh,cas3,cas2,cas1,cas4,cas5,cas7,cas8b2,cas6	0	11	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_016894_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016894_1

2375564-2375657

Orphan

Consensus_repeat	Method
ATTGCCGCCATGTCCGCCATTACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016894_1

>merge|NC_016894|1|2375564-2375657|CRISPRCasFinder
ATTGCCGCCATGTCCGCCATTACCGCCATCCGGACCTCCGTTAGGAACATATTTTTCGCGTCGGAAACTCATTCCGCCATGTCCGCCATTACCG

>NC_016894|1|1|2375564-2375657|CRISPRCasFinder
ATTGCCGCCATGTCCGCCATTACCG	CCATCCGGACCTCCGTTAGGAACATATTTTTCGCGTCGGAAACT
CATTCCGCCATGTCCGCCATTACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016894.1\|WP_014356372.1\|2366882_2368799_-\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234752
NC_016894.1\|WP_014356369.1\|2363625_2364420_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224026
NC_016894.1\|WP_014356371.1\|2365405_2366398_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380548
NC_016894.1\|WP_014356383.1\|2377212_2377932_+\|class-B-sortase	unknown	unknown	gnl\|CDD\|320675
NC_016894.1\|WP_014356380.1\|2375805_2376093_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NC_016894.1\|WP_193353282.1\|2377991_2379428_-\|sodium:alanine-symporter-family-protein	unknown	unknown	gnl\|CDD\|224040
NC_016894.1\|WP_052307079.1\|2373994_2374357_-\|YhbY-family-RNA-binding-protein	unknown	unknown	gnl\|CDD\|376702
NC_016894.1\|WP_014356386.1\|2380968_2382816_-\|TIGR03960-family-B12-binding-radical-SAM-protein	unknown	unknown	gnl\|CDD\|188475
NC_016894.1\|WP_041668690.1\|2364419_2365316_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226605
NC_016894.1\|WP_041668697.1\|2382987_2383419_-\|EamA-family-transporter	unknown	unknown	unknown
NC_016894.1\|WP_014356382.1\|2376444_2376762_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NC_016894.1\|WP_083837880.1\|2383461_2384241_-\|protein-kinase-family-protein	unknown	unknown	gnl\|CDD\|270622
NC_016894.1\|WP_041671287.1\|2384176_2384881_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NC_016894.1\|WP_014356377.1\|2373335_2373977_-\|nicotinate-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
NC_016894.1\|WP_014356373.1\|2369239_2370940_-\|B12-binding-domain-containing-radical-SAM-protein	unknown	unknown	gnl\|CDD\|379119
NC_016894.1\|WP_014356381.1\|2376105_2376438_-\|ribosomal-processing-cysteine-protease-Prp	unknown	unknown	gnl\|CDD\|381747
NC_016894.1\|WP_014356374.1\|2371104_2372202_-\|redox-regulated-ATPase-YchF	unknown	unknown	gnl\|CDD\|236583
NC_016894.1\|WP_041668692.1\|2372773_2373349_-\|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-YqeK	unknown	unknown	gnl\|CDD\|224627
NC_016894.1\|WP_014356385.1\|2380292_2380976_-\|DUF2344-domain-containing-protein	unknown	unknown	gnl\|CDD\|378393
NC_016894.1\|WP_014356375.1\|2372428_2372773_-\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|376779

Protein	Function_ID	Function_description	E-value
NC_016894.1\|WP_014356372.1\|2366882_2368799_-\|threonine--tRNA-ligase	gnl\|CDD\|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
NC_016894.1\|WP_014356369.1\|2363625_2364420_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224026	COG1101, PhnK, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	3.97448e-122
NC_016894.1\|WP_014356371.1\|2365405_2366398_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380548	cd06325, PBP1_ABC_unchar_transporter, type 1 periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally.	1.42098e-120
NC_016894.1\|WP_014356383.1\|2377212_2377932_+\|class-B-sortase	gnl\|CDD\|320675	cd05826, Sortase_B, Sortase domain found in class B sortases. Class B sortases are membrane-bound cysteine transpeptidases broadly distributed in Gram-positive bacteria (mainly present in Firmicutes and Actinobacteria). They can have radically distinct functions. Some members of this group attach haemoproteins to the peptidoglycan of the cell wall, while others assemble pili, which are multi-subunit hair-like fibres that extend from the cell surface to promote microbial adhesion and biofilm formation. In transpeptidation reaction, the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class B sortases normally recognize the consensus NP[Q/K][T/S][N/G/S][D/A] motif), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase B protein from Staphylococcus aureus (named Sa-SrtB) cleaves surface protein precursors between threonine and asparagine at a conserved NPQTN motif with subsequent covalent linkage to pentaglycine cross-bridges. It is required for anchoring the heme-iron binding surface protein IsdC to the cell wall envelope. SrtB contains an N-terminal hydrophobic region that functions as a signal peptide/transmembrane domain. At the C terminus, it contains an essential cysteine residue within the catalytic TLXTC signature sequence, where X is usually a serine. Genes encoding SrtB and its targets are generally clustered in the same locus. The prototypical class B sortase involved in pilus biogenesis is pilus-specific sortase C2 from Streptococcus pyogenes (named Sp-SrtC2) that anchors a surface protein containing a QVPTGV motif to the cell wall, as well as polymerizes the major pilin subunit Tee3/FctA and attaches the minor tip pilin Cpa. The linkage of Cpa to Tee3 by SrtC2 requires the VPPTG motif in the cell wall-sorting signal of Cpa. The family also includes SrtB enzymes from Bacillus anthracis (named Ba-SrtB) and Clostridium difficile (named Cd-SrtB). Ba-SrtB is thought to recognize the NPKTG motif, and attaches surface proteins to meso-diaminopimelic acid (mDAP) cross-bridges. Cd-SrtB does not play an essential role in pathogenesis. It cleaves short [SP]PXTG motif-containing peptides between the threonine and glycine residues and then covalently anchors the threonine residue to a nucleophile such as glycine or mDAP, but not to the peptidoglycan of C. difficile, suggesting a novel association of sortase activity with cyclic diGMP (c-diGMP)-mediated regulation to control levels of cell wall anchoring and secretion of putative adhesion molecules.	1.42737e-67
NC_016894.1\|WP_014356380.1\|2375805_2376093_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	2.91343e-55
NC_016894.1\|WP_193353282.1\|2377991_2379428_-\|sodium:alanine-symporter-family-protein	gnl\|CDD\|224040	COG1115, AlsT, Na+/alanine symporter [Amino acid transport and metabolism].	0
NC_016894.1\|WP_052307079.1\|2373994_2374357_-\|YhbY-family-RNA-binding-protein	gnl\|CDD\|376702	pfam01985, CRS1_YhbY, CRS1 / YhbY (CRM) domain. Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly. GFP fused to a single-domain CRM protein from maize localizes to the nucleolus, suggesting that an analogous activity may have been retained in plants. A CRM domain containing protein in plant chloroplasts has been shown to function in group I and II intron splicing. In vitro experiments with an isolated maize CRM domain have shown it to have RNA binding activity. These and other results suggest that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes. YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome.	3.1383e-30
NC_016894.1\|WP_014356386.1\|2380968_2382816_-\|TIGR03960-family-B12-binding-radical-SAM-protein	gnl\|CDD\|188475	TIGR03960, radical_SAM_domain_protein, radical SAM family uncharacterized protein. This model describes a radical SAM protein, or protein region, regularly found paired with or fused to a region described by TIGR03936. PSI-BLAST analysis of TIGR03936 suggests a relationship to the tRNA pseudouridine synthase TruA, suggesting that this system may act in RNA modification. [Unknown function, Enzymes of unknown specificity].	0
NC_016894.1\|WP_041668690.1\|2364419_2365316_-\|ABC-transporter-permease	gnl\|CDD\|226605	COG4120, COG4120, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.61985e-99
NC_016894.1\|WP_014356382.1\|2376444_2376762_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	6.00429e-45
NC_016894.1\|WP_083837880.1\|2383461_2384241_-\|protein-kinase-family-protein	gnl\|CDD\|270622	cd00180, PKc, Catalytic domain of Protein Kinases. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.	9.82948e-26
NC_016894.1\|WP_041671287.1\|2384176_2384881_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	6.31978e-99
NC_016894.1\|WP_014356377.1\|2373335_2373977_-\|nicotinate-nucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	9.36335e-76
NC_016894.1\|WP_014356373.1\|2369239_2370940_-\|B12-binding-domain-containing-radical-SAM-protein	gnl\|CDD\|379119	pfam13311, DUF4080, Protein of unknown function (DUF4080). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	3.48629e-40
NC_016894.1\|WP_014356381.1\|2376105_2376438_-\|ribosomal-processing-cysteine-protease-Prp	gnl\|CDD\|381747	cd16332, Prp-like, ribosomal-processing cysteine protease Prp and similar proteins. This model represents a family of cysteine proteases that include members found to cleave the N-terminus extension of ribosomal subunit L27 in eubacteria. Proteins in this family are distinguished by a pair of invariant histidine and cysteine residues with conserved spacing that form the classic catalytic dyad of a cysteine protease. Dependence of Staphylococcus aureus on L27 cleavage by Prp makes the enzyme a target for antibiotic development.	3.91186e-30
NC_016894.1\|WP_014356374.1\|2371104_2372202_-\|redox-regulated-ATPase-YchF	gnl\|CDD\|236583	PRK09601, PRK09601, redox-regulated ATPase YchF.	0
NC_016894.1\|WP_041668692.1\|2372773_2373349_-\|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-YqeK	gnl\|CDD\|224627	COG1713, COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism].	1.05784e-61
NC_016894.1\|WP_014356385.1\|2380292_2380976_-\|DUF2344-domain-containing-protein	gnl\|CDD\|378393	pfam10105, DUF2344, Uncharacterized protein conserved in bacteria (DUF2344). This domain, found in various hypothetical bacterial proteins and Radical Sam domain proteins, has no known function. This domain is distantly related to tRNA pseudouridine synthases, suggesting this family may carry out a function related to RNA modification. But this family appears to lack the catalytic aspartate found in pseudouridine synthases.	6.20794e-67
NC_016894.1\|WP_014356375.1\|2372428_2372773_-\|ribosome-silencing-factor	gnl\|CDD\|376779	pfam02410, RsfS, Ribosomal silencing factor during starvation. This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.	4.30829e-46

>NC_016894.1|WP_052307079.1|2373994_2374357_-|YhbY-family-RNA-binding-protein
MLTSKQRSYLRKLAMDIPDIIFIGKDGLTPQVIVQTKDAIIARELIKGKVQNNSLEDVKDVAQALAAATKSDIVCTIGNKFVLYKKNLLKTKIEVPTKNQKPIKRVKKKALNPLRKFSNS
>NC_016894.1|WP_014356377.1|2373335_2373977_-|nicotinate-nucleotide-adenylyltransferase
MKKKIGLLGGTFNPIHTGHLLLAESARDQYELDKVLFIPTGNNPFKLSQDEITRKHRLKMVELAINGNDYFEILTHEIDQNGITYTIDTINIIKEIYPDCDFYFIAGADLMFEITLWKGASELLKSVKFITTFRPGYSHERLDMRIKELQEIYGASIYKLYATEMDIASSDIRARIKNGYSIRYLLPDSVAAYIHTHGLYLSELPFEDENESD
>NC_016894.1|WP_041668692.1|2372773_2373349_-|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-YqeK
MNRTEIEADLKKKLSAKRFRHTQNVVEAASNLAYIYGCNVDQVSLAALLHDCAKYFSDQQLLQYAKKHHLKVDRVSRYNQQLLHGPVGAIVAKQTYGVEDVAILHAICYHTTGCKEMTTLDEIIYLADYIEKDRSFPGIEDIRKMADTNLDLATIMALTNSICYVASVGDLIHKRTIDARNDLIIKNKKRK
>NC_016894.1|WP_014356375.1|2372428_2372773_-|ribosome-silencing-factor
MIFIIPEEFAQKIKEWIDNKNGFDIEVINVTEMTSIANYFVIASGSSERQVKAIADNIEYEAKELEIFPKGIEGQREGRWILLDYYDVIIHIFHAEERGFYSLEKLWKDSEVSR
>NC_016894.1|WP_014356374.1|2371104_2372202_-|redox-regulated-ATPase-YchF
MKIGIVGLPNVGKSTIFNALTKAGAESANYPFCTIDPNIGVVAVPDFRLAVLEKMYNSKKVIPTSIEFVDIAGLVRGASKGEGLGNKFLSHIREVDAIVHVVRCFEDDNVVHVEGKIDPIDDLETINMELIFADLEMLDRRIEKNKKLAKTNPQEKANIEVAMRLREILETGKMPNDDEFSADEWEFIQTIQLISIKPVLYIANVSEDDLHEDNEMVTRLKATVLENHSGNHKDIIKISAKIEEEIAQFDDAEKAEFLSDMGLAESGLDQVIRTGYKLLGLITFLTAGPQEIRAWTVTDGTKAPQAAGKIHSDIERGFIRAEITSYDQLIEAGSEVKAKESGVTRVEGKDYVMKDGDVTFFRFNV
>NC_016894.1|WP_014356373.1|2369239_2370940_-|B12-binding-domain-containing-radical-SAM-protein
MKDLVLVAINAKYIHTNLAVRVLKAQLLEFEIEILEMSINDSMHRIVQQLMDIDTKIIGFSCYIWNIEIIFKLAEIIKKAKPTVQIMLGGPEVSFDGKALLETYSFCDFIIQGEGENKLQQFMNNPQNLAEISGLCFRDENGIVWENTDDKPLALNNLTFAYFQNDLESLKHKIIYYETMRGCPFSCSYCLSSVNNGVNMLPLERVYEELDFFIQAGVKQVKLVDRTFNCNLRRTKDIFRYLIKCGGTTNFHFEMTGDLIDDEMILLLKSAPAGLIQFEIGIQSTDPITLKAIGRKISLTQTEKNVKKLLEPQNIHIHLDLIAGLPYETYLVFKSSFNRVIALFPDMLQLGFLKCLKGTRIRKEADIHDYRYTSFPPYEIISNKYINAKELYQLRQIEMLVDRYFNSGAFKYTMHFIIQTNLFDTPFDFFEQFSFYWAEQGYYDMGKSKEQLYGIIGEFCEKHQKGQLIKEYLKFDFLTNGNLRLPSGMVDNSPNKEWIFEFLKEPRHIETYLSDFINFAPKKIYNQIKFQNFSQLFMEQFFGKTSVNTNKSSLLLFTEKSYQVVN
>NC_016894.1|WP_014356372.1|2366882_2368799_-|threonine--tRNA-ligase
MITITLKDGSIKNYEPGITVLDVANDISSGLAKNTMAGELNGEVVDIRQPINENSTLNLLKFEDAGGQHAFWHTGSHLLAQAIKRLYPQAKLAIGPAIENGFYYDIDLDVIITPEIMEKIEKEMAKIVKEGLKINRYELSRQEALEKVTKEGEIYKAELIENLPADAIISFYSQGEFSDLCAGPHIQNLSGIKAIKLLSLAGAYWRGDEKNKMLQRIYGITFPKKSQLDEYLTRLEEAKKRDHRKLGKELDLFSLHEEGPGFPFFHPKGMIIRNELENFWREEHQRRGYHEIKTPIILNNDLWKRSGHWDKYKENMYFTEIDESEYAIKPMNCPGGMLVYKTKGHSYRDLPLKMGELGLVHRHELHGALHGLMRVRAFTQDDAHIFMTPEQIQEEVIKVIDLADDVYKIFGFSYKVELSTQPENSIGSDEVWEIATEALRKALEKKEINYRLNPGDGAFYGPKIDFHLEDSLGRTWQCGTIQLDFQMPERFDLNYIGSDGEKHRPVIIHRTILGSIERFFGILIEHFAGKFPVWLAPVQVMIIPVADAHHDFAKGIADQLTALGVRASVDGRDEKLGYRIREAQLQKVPYMLVVGEKEAEGGDLALRIRDTGDAGLISLADLKEKLIEKIKTKSLTLD
>NC_016894.1|WP_014356371.1|2365405_2366398_-|ABC-transporter-substrate-binding-protein
MKKNGKKLMAILFATTLVVLGAGCTSSATKEESKNVSIGIVQYVDHVALDAAREGFISALADNGYTDGDNITIDVQNAQGDQSNLSTISDRFVSNKVDLVLAIATPAAQAIAGKTTEIPILGTAITDYVAARLVKSNEAPGGNVTGTTDMNPISEQIDLLVKLVPTAKTVGVLYTSSEDNSVIQAKIAKEAIEKLGMKYVEVTVTNSNDVQQATQSIVSQCDAIYIPTDNVFASAMPQVENITTQSKTPVICGESGMVESGGLATLGINYSDLGYQTGLMAVKIIKGEAKPATMPIESATKFDYAINGSVAQEIGLTIPADLQQYIITTK
>NC_016894.1|WP_041668690.1|2364419_2365316_-|ABC-transporter-permease
MLQIILGAISLGLLWAIMTIGVYITYRILDIADLTVEGSIAMGAAIAAFSIFNGMNPFLATALAFVGGMLAGLVTGILHTKLKIPALLAGILTMIALYSVNLRIMGKANLSLLRIDTVFTSLENLGLDPTNAVMLFGFISVMIIVALLYWFFGTEIGCAIRATGNNPQMARAQGINTNNMIILGLVISNGLVALSGSLIAQSQSFADIQMGIGSIVIGLASVIIGEVIFGTRNFLNCLISLVLGAITYRIIIALVLKLGMPANDLKLFTAITVAIALSLPILKSYLRPFKKSIKGGDL
>NC_016894.1|WP_014356369.1|2363625_2364420_-|ATP-binding-cassette-domain-containing-protein
MLVIKDVEKKFNPETVNEKIALSNLSLTLEEGDFVTLIGGNGAGKSTLLNCVAGVFGVERGTISINGMDVTKLPEYKRSSFIGRVFQDPMMGTAGNMGIEENLALAYRRGKMRSLSWGISQKEREIYKEYLSHLDLGLENRLNAKVGLLSGGQRQALTLLMATLKKPKLLLLDEHTAALDPKTADKVLKLSDQFVKDGNLTTLMVTHNMRHAIEHGNRLIMMHSGRVILDIKGEEKKKLTVDELLKRFGQVSGEEFANDRALLS
>NC_016894.1|WP_014356380.1|2375805_2376093_-|50S-ribosomal-protein-L27
MLKMNLQLFAHKKGVGSSRNGRDSEAKRLGVKRGDGQFVLAGNILVRQRGTKIHPGTNVGKGGDDTLFALEDGIVRFERKGRDKKQVSIYPREAI
>NC_016894.1|WP_014356381.1|2376105_2376438_-|ribosomal-processing-cysteine-protease-Prp
MISVKIQGKNNIATEIIVSGHAGFADHGEDIVCAAVSVLTISILNGLTEIIGRKDLDEVIEEGYVHFLIPQVDDGPMKIKTDTLISTYLLGIRGIKEAYGDYIQFEEVYK
>NC_016894.1|WP_014356382.1|2376444_2376762_-|50S-ribosomal-protein-L21
MYAIIKTGGKQYRVQENDVIQIEKINFSEEDVKEITFTEVLAVNKDGEMVIGTPVVENAVVKAEILEVAKGPKVIIYKYKSKKDYRKKQGHRQPFMKVKITGIQA
>NC_016894.1|WP_014356383.1|2377212_2377932_+|class-B-sortase
MKLRSNITKTKLIASVILILMALTFGIYNYYPTFSNSIEKDKIIAVAKENKLDTQDRVDFSGLLALNSQTVGWVQIDGTPLEYPVVQTDNNDHYLSFNFLNNESFEGAIFQDYLCDTINTRNHILYGHYMSDESMFGSLWNYQDKSYYEHHPVIQFDQPGNPGDWEIFSVYVTEADYDYRQPKFSSDTDFLNYMSRLKKRSLYDTGVDISPSDEVLTLSTCIYTFDNARLAVHARKIKK
>NC_016894.1|WP_193353282.1|2377991_2379428_-|sodium:alanine-symporter-family-protein
MNFSEIIAAVNNFVWGPIMLALLMGTGIFLTIRLKFLPWRNLGYALKSVFAKPDPSKKDSSGDISPFQSLMTALAATIGTGNIVGVATAMVLGGPGALVWMWISALFGLSTKYGESVLAVKYRETNVEGEMAGGPMYAMKNGFKNKTIGSILAVLFSGFAVIASFGIGNMTQANSISGAVLGTFGIPTWITGAVITILALVVLLGGIKSIGRVCGVIVPFMAVFYFLGGILVIIINFQNIPAGIAQIFTMAFSPTAIAGGVGGTVIASMLSAMRWGVARGVFSNEAGLGSAPIAAAAAKTDHPSRQGYINMTGTFFDTLVVCTVTGLVIASSGVLGTVTESGKLLSGADLTIASFESVLGPIGGYLVTIGIMLFAFSTILGWEYYGEKSLEYLIKAPIAIKAYRFIFSIVTFIGATTALQIVWDFSDTMNGLMAIPNLISLLVLSNVIAKECFDYEEKIIKPERESRRLEKKAIVENE
>NC_016894.1|WP_014356385.1|2380292_2380976_-|DUF2344-domain-containing-protein
MVKIQYQFKRTKRLRFLSHLDQQRLFQRAFRRADIPVEYSQGFNPHPKMSFALAMSVGLTSDGEYGEVIVSKDIDVDEFINSMNQVLPKGLEIISAMVCPAEVESLSASLRKSVYRLELNLAPGIEIEKATKTIESFLALPQILIQKRNKKGKFVEKDIRPFIESLLVIEDDEEEKLNLKMTLLYIDQQCVKPEQIIESINNQNGVIFLIDPTTRIHREKLLLNADS
>NC_016894.1|WP_014356386.1|2380968_2382816_-|TIGR03960-family-B12-binding-radical-SAM-protein
MNNFIEENILPLVTKPITYLGNEVNAVHKTPNEDMVRFAFAFPDTYEVGMSHLGMKILYGLLNEEKDIWCERVFAPWVDMEEQLRLHQLPLYGLESMMPLYQYDFVGFTLQYEMSFSNILNMLELGQIPLRTSQRRETDPFIIAGGPCAYNPEPLSDFIDIFVIGEGELVILEIMENYRQWQKTNGNRQEFLISVAGIEGVYVPSLYEVTYDESSGVISAFKPIVKEASKTIRKRFIEDLDNAYFPDKIVVSYTETVHDRISYEIFRGCGRGCRFCQAGMIYRPTREKAPATIQEKIKALIKVTGYDEVSLSSLSSGDYSEIELLIKNLVNEYEDQKVSISLPSLRIDSLSIDMLEEIQKVRKTGLTLAPEAGTQRMRDVINKGVTEKNLLDTVHLAFEKGWGHVKLYFMIGLPGETMEDIEGIADLGQKVVGEYLKIDRSLRNKSLKVVLSTSSFVPKAFTPFQWMGQNSQELFKDKQRHLKMSIKDRKISYSWHDSGVSFLEAVFARGDRRLCEVLEIAHKKGCRFDGWGEFFDFGKWMEAFSEAGVDPDFYALRKRSYTEILPWDFIDTGVTKKYLIAEALKAESALTTPFCPENCSNCGIMEFKKGWKCNG
>NC_016894.1|WP_041668697.1|2382987_2383419_-|EamA-family-transporter
MKELSYYLPIILIVIANVFYNICTKSTPESVNPFLSLMVTYLVAALLTFFLMLANGLNEGIVDAFKRLNWTSFALGIAVVALEFGYITAYRLGWNISIGSVVANILLAIILIPIGLLCYKEILTTNQLIGIFLCLAGLVFINR
>NC_016894.1|WP_083837880.1|2383461_2384241_-|protein-kinase-family-protein
MVRYRKVILMKNPCQLMKSNGKKVISLEGALSYWGFRLKQRIGQGRFGTCYEISGNSGNYVLKLYHANDVKRRKEKLVWEGKWLKMVDHPAIPEVIADFDQDGFYGLILEKMTGNDLEALIDSDHEFKKEEIIAILTQLIEIVDYLYGLKISHRDLKVSNILWTGSKLALIDFGSARFIPQFNKRFNPDFWGIGDVFMRLSAMCHEIMPSSDDFLIDQLRLNDNEKIVLKRMLYIETPYQNINELKHDFNAAFLNNNLI
>NC_016894.1|WP_041671287.1|2384176_2384881_-|ABC-transporter-ATP-binding-protein
MKHFIEFKDVYKRYHMGEVTINAANGINFFIDEGQFAVVVGPSGAGKTTVLNILGGMDSCDEGEVIVGKKNVAALTRKELAEYRRYDTGFVFQFYNLVQNLTAVENVELATQICRDPKDAEMVLKSVGLEERLANFPSQLSGGEQQRVAIARALAKRPKLLLCDEPTGALDYNTGKNILKLLQETSRKENMTVILITHNQAITPMADKVIIMKNGQVQKSYLNEKPLSVDEIEW

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Crispr_ID: NC_016894_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016894_2

3377721-3380835

Unclear

Consensus_repeat	Method
ATTTACATTCCAATATGGATCTACTCAAAT	CRISPRCasFinder
ATTTACATTCCAATATGGATCTACTCAAAT	CRT
ATTTACATTCCAATATGGATCTACTCAAAT	PILER-CR

47 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6,WYL

The CRISPR arrays of NC_016894_2

>merge|NC_016894|2|3377721-3380835|CRISPRCasFinder,CRT,PILER-CR
AAACCGATTCCAATATGGATCTACTCAAATAATAAATTGAGATGGCAAAATGTTATATTCATTCAATTTACATCCAATATGGATCTACTCAAATTTTGGCGACCGTAGAAATTGTCGTTTGGGTTCTGATATTTACATTCCAATATGGATCTACTCAAATGATGGCGCTTGCAAGGGTAATCCCGGCGTTGGTGGTATTTACATTCCAATATGGATCTACTCAAATCAAGGTTGAATTCCGAGAATTGGTAGCGGCGGATTAATTTACATTCCAATATGGATCTACTCAAATTGGGTGGCGTAACCCAAAGCTTAACAGACCGGATCAGATTTACATTCCAATATGGATCTACTCAAATGAAAATGAAGTCAATGCCCTAGCCCCGGCATTGCATTTACATTCCAATATGGATCTACTCAAATATCAGTGTCGGTGCGTCTTCGGACAACGCAACTTTTATTTACATTCCAATATGGATCTACTCAAATTAATCGATTAAGTTCTTCAACAACATCATCCACGAAATTTACATTCCAATATGGATCTACTCAAATCTTCTAATTGCGATACTAGGTCATAGGCCTTTTGCATTTACATTCCAATATGGATCTACTCAAATCGGTATATGTAAAGCCGTTCGGGTGTTGGTAGCACGATTTACATTCCAATATGGATCTACTCAAATTTGCGCTTTTTGTCAACGAGATTGATGGAGAAATGAATTTACATTCCAATATGGATCTACTCAAATTTTATTATAAGAATGAACGGGAAGTTATGGAATCGTATTTACATTCCAATATGGATCTACTCAAATACGATCAGCCCCAACACTATTAGCCTGTTCAACTGATTTACATTCCAATATGGATCTACTCAAATAAAGTCTCCCCGAAGCTGATAGCCTGATAGTTATTATTTACATTCCAATATGGATCTACTCAAATGACTATAAAAATGTTGTTACTAACGTAAAGCCAAAATTTACATTCCAATATGGATCTACTCAAATGCGCTTAAAAGCCCTCTTCAATTCAAATTTCCAAAATTTACATTCCAATATGGATCTACTCAAATTACGATTGATATACCGTTTATACTCTTTACTTTGAAATTTACATTCCAATATGGATCTACTCAAATTTGTAGTTCGTCCATTGCCATTTTAACCGCATCGGTATTTACATTCCAATATGGATCTACTCAAATTCTTAATAACATTCATCTCATCACCTCATAGAATAAATTTACATTCCAATATGGATCTACTCAAATTTGTTTATTAATGATCAAGTGTTTAGCATTAAGATGATTTACATTCCAATATGGATCTACTCAAATAAAATGGAGAATTAAATACAACTAGTTCACCATCATTTACATTCCAATATGGATCTACTCAAATGATTATAAAGTAATGATAAATCAATCACTAAATTAACATTTACATTCCAATATGGATCTACTCAAATCCCCCATTGCCTAATTCTCTTGCGCAAATAGCCCAAATTTACATTCCAATATGGATCTACTCAAATAAAATGGTTGAAGTCGTATTAGAAGACGTTGGCAACATTTACATTCCAATATGGATCTACTCAAATTAAACTAAATACCGGCAGAACAGGACGCTTCCAAAATTTACATTCCAATATGGATCTACTCAAATATACGTAATCTCTATCAGTAATAGTGCCATACGTTATTTACATTCCAATATGGATCTACTCAAATACAAAATAACAGATAAGCCGCTGTTCTGCTATTGTAATTTACATTCCAATATGGATCTACTCAAATGCTAGCAGAGATCAAAACCGTCGATGGACCTAGCAGATTTACATTCCAATATGGATCTACTCAAATCGTATTGCCCTGAGCTGTCCAGGTACGTAAACTTATTTACATTCCAATATGGATCTACTCAAATTCTTTTGCAAATCGATTGTCGTAACCGCTTTTAAAATTTACATTCCAATATGGATCTACTCAAATCAACCGGACTGGCCGCGAAATATTATTGTAGTTGATTTACATTCCAATATGGATCTACTCAAATGCATTACCAATTATTTGGAAAGCACCTGTGAAAAGATTTACATTCCAATATGGATCTACTCAAATAAGAATTGTTTCTTTTGCTTTTCTCATGTCTTCAAATTTACATTCCAATATGGATCTACTCAAATAAAATGGTTGAAGTCGTATTAGAAGACGTTGGCAACATTTACATTCCAATATGGATCTACTCAAATTCGCCATCGTCATTCCCAGTAACGACAATATCCGAATTTACATTCCAATATGGATCTACTCAAATATTTATCCCGATATTGAAGCGGTTTTCATTGATACATTTACATTCCAATATGGATCTACTCAAATTAATGCATCGATAATCTCAATGCCGGCATTAATTTTTCATTTACATTCCAATATGGATCTACTCAAATAGAAATAAATTAGTTGATGAACTCAACACGAAATAATTTACATTCCAATATGGATCTACTCAAATAACAATCCGGGTAAACCGATCCGGCGTCATAACAGTATTTACATTCCAATATGGATCTACTCAAATGACGATTTAATTAAAGCTATTAATGATTTTGATTCATTTACATTCCAATATGGATCTACTCAAATTAATACTGTTTATTTTTCTTTTCAGATCATTATAAGATTTACATTCCAATATGGATCTACTCAAATCGCCGGGGCCTCTCCCAAGAGTAGGTCAGCAATCTTAATTTACATTCCAATATGGATCTACTCAAATCTTTTTACATCTTTTAAGTTCATTTTTATTCCTCCCATTTACATTCCAATATGGATCTACTCAAATCCCGCATTGACGCTATTATTTGTTATTTCTCTACTCATTTACATTCCAATATGGATCTACTCAAATGTTGACAAAATACGCATTGCGTACTAGAATAAACGCAATTTACATTCCAATATGGATCTACTCAAATTGATAAGAGTATTAACTTAACGACATCTTTAACAAAAATTTACATTCCAATATGGATCTACTCAAATCTTAACATTTTGATTCTTGATATTGTTCTTGCATTGATTTACATTCCAATATGGATCTACTCAAAT

>NC_016894|2|2|3377721-3380835|CRISPRCasFinder
AAACCGATTCCAATATGGATCTACTCAAAT	AATAAATTGAGATGGCAAAATGTTATATTCATTC
AATTTACATCCAATATGGATCTACTCAAAT	TTTGGCGACCGTAGAAATTGTCGTTTGGGTTCTGAT
ATTTACATTCCAATATGGATCTACTCAAAT	GATGGCGCTTGCAAGGGTAATCCCGGCGTTGGTGGT
ATTTACATTCCAATATGGATCTACTCAAAT	CAAGGTTGAATTCCGAGAATTGGTAGCGGCGGATTA
ATTTACATTCCAATATGGATCTACTCAAAT	TGGGTGGCGTAACCCAAAGCTTAACAGACCGGATCAG
ATTTACATTCCAATATGGATCTACTCAAAT	GAAAATGAAGTCAATGCCCTAGCCCCGGCATTGC
ATTTACATTCCAATATGGATCTACTCAAAT	ATCAGTGTCGGTGCGTCTTCGGACAACGCAACTTTT
ATTTACATTCCAATATGGATCTACTCAAAT	TAATCGATTAAGTTCTTCAACAACATCATCCACGAA
ATTTACATTCCAATATGGATCTACTCAAAT	CTTCTAATTGCGATACTAGGTCATAGGCCTTTTGC
ATTTACATTCCAATATGGATCTACTCAAAT	CGGTATATGTAAAGCCGTTCGGGTGTTGGTAGCACG
ATTTACATTCCAATATGGATCTACTCAAAT	TTGCGCTTTTTGTCAACGAGATTGATGGAGAAATGA
ATTTACATTCCAATATGGATCTACTCAAAT	TTTATTATAAGAATGAACGGGAAGTTATGGAATCGT
ATTTACATTCCAATATGGATCTACTCAAAT	ACGATCAGCCCCAACACTATTAGCCTGTTCAACTG
ATTTACATTCCAATATGGATCTACTCAAAT	AAAGTCTCCCCGAAGCTGATAGCCTGATAGTTATT
ATTTACATTCCAATATGGATCTACTCAAAT	GACTATAAAAATGTTGTTACTAACGTAAAGCCAAA
ATTTACATTCCAATATGGATCTACTCAAAT	GCGCTTAAAAGCCCTCTTCAATTCAAATTTCCAAA
ATTTACATTCCAATATGGATCTACTCAAAT	TACGATTGATATACCGTTTATACTCTTTACTTTGAA
ATTTACATTCCAATATGGATCTACTCAAAT	TTGTAGTTCGTCCATTGCCATTTTAACCGCATCGGT
ATTTACATTCCAATATGGATCTACTCAAAT	TCTTAATAACATTCATCTCATCACCTCATAGAATAA
ATTTACATTCCAATATGGATCTACTCAAAT	TTGTTTATTAATGATCAAGTGTTTAGCATTAAGATG
ATTTACATTCCAATATGGATCTACTCAAAT	AAAATGGAGAATTAAATACAACTAGTTCACCATC
ATTTACATTCCAATATGGATCTACTCAAAT	GATTATAAAGTAATGATAAATCAATCACTAAATTAAC
ATTTACATTCCAATATGGATCTACTCAAAT	CCCCCATTGCCTAATTCTCTTGCGCAAATAGCCCAA
ATTTACATTCCAATATGGATCTACTCAAAT	AAAATGGTTGAAGTCGTATTAGAAGACGTTGGCAAC
ATTTACATTCCAATATGGATCTACTCAAAT	TAAACTAAATACCGGCAGAACAGGACGCTTCCAAA
ATTTACATTCCAATATGGATCTACTCAAAT	ATACGTAATCTCTATCAGTAATAGTGCCATACGTT
ATTTACATTCCAATATGGATCTACTCAAAT	ACAAAATAACAGATAAGCCGCTGTTCTGCTATTGTA
ATTTACATTCCAATATGGATCTACTCAAAT	GCTAGCAGAGATCAAAACCGTCGATGGACCTAGCAG
ATTTACATTCCAATATGGATCTACTCAAAT	CGTATTGCCCTGAGCTGTCCAGGTACGTAAACTT
ATTTACATTCCAATATGGATCTACTCAAAT	TCTTTTGCAAATCGATTGTCGTAACCGCTTTTAAA
ATTTACATTCCAATATGGATCTACTCAAAT	CAACCGGACTGGCCGCGAAATATTATTGTAGTTG
ATTTACATTCCAATATGGATCTACTCAAAT	GCATTACCAATTATTTGGAAAGCACCTGTGAAAAG
ATTTACATTCCAATATGGATCTACTCAAAT	AAGAATTGTTTCTTTTGCTTTTCTCATGTCTTCAA
ATTTACATTCCAATATGGATCTACTCAAAT	AAAATGGTTGAAGTCGTATTAGAAGACGTTGGCAAC
ATTTACATTCCAATATGGATCTACTCAAAT	TCGCCATCGTCATTCCCAGTAACGACAATATCCGA
ATTTACATTCCAATATGGATCTACTCAAAT	ATTTATCCCGATATTGAAGCGGTTTTCATTGATAC
ATTTACATTCCAATATGGATCTACTCAAAT	TAATGCATCGATAATCTCAATGCCGGCATTAATTTTTC
ATTTACATTCCAATATGGATCTACTCAAAT	AGAAATAAATTAGTTGATGAACTCAACACGAAATA
ATTTACATTCCAATATGGATCTACTCAAAT	AACAATCCGGGTAAACCGATCCGGCGTCATAACAGT
ATTTACATTCCAATATGGATCTACTCAAAT	GACGATTTAATTAAAGCTATTAATGATTTTGATTC
ATTTACATTCCAATATGGATCTACTCAAAT	TAATACTGTTTATTTTTCTTTTCAGATCATTATAAG
ATTTACATTCCAATATGGATCTACTCAAAT	CGCCGGGGCCTCTCCCAAGAGTAGGTCAGCAATCTTA
ATTTACATTCCAATATGGATCTACTCAAAT	CTTTTTACATCTTTTAAGTTCATTTTTATTCCTCCC
ATTTACATTCCAATATGGATCTACTCAAAT	CCCGCATTGACGCTATTATTTGTTATTTCTCTACTC
ATTTACATTCCAATATGGATCTACTCAAAT	GTTGACAAAATACGCATTGCGTACTAGAATAAACGCA
ATTTACATTCCAATATGGATCTACTCAAAT	TGATAAGAGTATTAACTTAACGACATCTTTAACAAAA
ATTTACATTCCAATATGGATCTACTCAAAT	CTTAACATTTTGATTCTTGATATTGTTCTTGCATTG
ATTTACATTCCAATATGGATCTACTCAAAT

>NC_016894|2|1|3377721-3380835|CRT
AAACCGATTCCAATATGGATCTACTCAAAT	AATAAATTGAGATGGCAAAATGTTATATTCATTC
AATTTACATCCAATATGGATCTACTCAAAT	TTTGGCGACCGTAGAAATTGTCGTTTGGGTTCTGAT
ATTTACATTCCAATATGGATCTACTCAAAT	GATGGCGCTTGCAAGGGTAATCCCGGCGTTGGTGGT
ATTTACATTCCAATATGGATCTACTCAAAT	CAAGGTTGAATTCCGAGAATTGGTAGCGGCGGATTA
ATTTACATTCCAATATGGATCTACTCAAAT	TGGGTGGCGTAACCCAAAGCTTAACAGACCGGATCAG
ATTTACATTCCAATATGGATCTACTCAAAT	GAAAATGAAGTCAATGCCCTAGCCCCGGCATTGC
ATTTACATTCCAATATGGATCTACTCAAAT	ATCAGTGTCGGTGCGTCTTCGGACAACGCAACTTTT
ATTTACATTCCAATATGGATCTACTCAAAT	TAATCGATTAAGTTCTTCAACAACATCATCCACGAA
ATTTACATTCCAATATGGATCTACTCAAAT	CTTCTAATTGCGATACTAGGTCATAGGCCTTTTGC
ATTTACATTCCAATATGGATCTACTCAAAT	CGGTATATGTAAAGCCGTTCGGGTGTTGGTAGCACG
ATTTACATTCCAATATGGATCTACTCAAAT	TTGCGCTTTTTGTCAACGAGATTGATGGAGAAATGA
ATTTACATTCCAATATGGATCTACTCAAAT	TTTATTATAAGAATGAACGGGAAGTTATGGAATCGT
ATTTACATTCCAATATGGATCTACTCAAAT	ACGATCAGCCCCAACACTATTAGCCTGTTCAACTG
ATTTACATTCCAATATGGATCTACTCAAAT	AAAGTCTCCCCGAAGCTGATAGCCTGATAGTTATT
ATTTACATTCCAATATGGATCTACTCAAAT	GACTATAAAAATGTTGTTACTAACGTAAAGCCAAA
ATTTACATTCCAATATGGATCTACTCAAAT	GCGCTTAAAAGCCCTCTTCAATTCAAATTTCCAAA
ATTTACATTCCAATATGGATCTACTCAAAT	TACGATTGATATACCGTTTATACTCTTTACTTTGAA
ATTTACATTCCAATATGGATCTACTCAAAT	TTGTAGTTCGTCCATTGCCATTTTAACCGCATCGGT
ATTTACATTCCAATATGGATCTACTCAAAT	TCTTAATAACATTCATCTCATCACCTCATAGAATAA
ATTTACATTCCAATATGGATCTACTCAAAT	TTGTTTATTAATGATCAAGTGTTTAGCATTAAGATG
ATTTACATTCCAATATGGATCTACTCAAAT	AAAATGGAGAATTAAATACAACTAGTTCACCATC
ATTTACATTCCAATATGGATCTACTCAAAT	GATTATAAAGTAATGATAAATCAATCACTAAATTAAC
ATTTACATTCCAATATGGATCTACTCAAAT	CCCCCATTGCCTAATTCTCTTGCGCAAATAGCCCAA
ATTTACATTCCAATATGGATCTACTCAAAT	AAAATGGTTGAAGTCGTATTAGAAGACGTTGGCAAC
ATTTACATTCCAATATGGATCTACTCAAAT	TAAACTAAATACCGGCAGAACAGGACGCTTCCAAA
ATTTACATTCCAATATGGATCTACTCAAAT	ATACGTAATCTCTATCAGTAATAGTGCCATACGTT
ATTTACATTCCAATATGGATCTACTCAAAT	ACAAAATAACAGATAAGCCGCTGTTCTGCTATTGTA
ATTTACATTCCAATATGGATCTACTCAAAT	GCTAGCAGAGATCAAAACCGTCGATGGACCTAGCAG
ATTTACATTCCAATATGGATCTACTCAAAT	CGTATTGCCCTGAGCTGTCCAGGTACGTAAACTT
ATTTACATTCCAATATGGATCTACTCAAAT	TCTTTTGCAAATCGATTGTCGTAACCGCTTTTAAA
ATTTACATTCCAATATGGATCTACTCAAAT	CAACCGGACTGGCCGCGAAATATTATTGTAGTTG
ATTTACATTCCAATATGGATCTACTCAAAT	GCATTACCAATTATTTGGAAAGCACCTGTGAAAAG
ATTTACATTCCAATATGGATCTACTCAAAT	AAGAATTGTTTCTTTTGCTTTTCTCATGTCTTCAA
ATTTACATTCCAATATGGATCTACTCAAAT	AAAATGGTTGAAGTCGTATTAGAAGACGTTGGCAAC
ATTTACATTCCAATATGGATCTACTCAAAT	TCGCCATCGTCATTCCCAGTAACGACAATATCCGA
ATTTACATTCCAATATGGATCTACTCAAAT	ATTTATCCCGATATTGAAGCGGTTTTCATTGATAC
ATTTACATTCCAATATGGATCTACTCAAAT	TAATGCATCGATAATCTCAATGCCGGCATTAATTTTTC
ATTTACATTCCAATATGGATCTACTCAAAT	AGAAATAAATTAGTTGATGAACTCAACACGAAATA
ATTTACATTCCAATATGGATCTACTCAAAT	AACAATCCGGGTAAACCGATCCGGCGTCATAACAGT
ATTTACATTCCAATATGGATCTACTCAAAT	GACGATTTAATTAAAGCTATTAATGATTTTGATTC
ATTTACATTCCAATATGGATCTACTCAAAT	TAATACTGTTTATTTTTCTTTTCAGATCATTATAAG
ATTTACATTCCAATATGGATCTACTCAAAT	CGCCGGGGCCTCTCCCAAGAGTAGGTCAGCAATCTTA
ATTTACATTCCAATATGGATCTACTCAAAT	CTTTTTACATCTTTTAAGTTCATTTTTATTCCTCCC
ATTTACATTCCAATATGGATCTACTCAAAT	CCCGCATTGACGCTATTATTTGTTATTTCTCTACTC
ATTTACATTCCAATATGGATCTACTCAAAT	GTTGACAAAATACGCATTGCGTACTAGAATAAACGCA
ATTTACATTCCAATATGGATCTACTCAAAT	TGATAAGAGTATTAACTTAACGACATCTTTAACAAAA
ATTTACATTCCAATATGGATCTACTCAAAT	CTTAACATTTTGATTCTTGATATTGTTCTTGCATTG
ATTTACATTCCAATATGGATCTACTCAAAT

>NC_016894|2|1|3377793-3380835|PILER-CR
TCCAATATGGATCTACTCAAATTTTGGCGA	CCGTAGAAATTGTCGTTTGGGTTCTGATATTTACAT
TCCAATATGGATCTACTCAAATGATGGCGC	TTGCAAGGGTAATCCCGGCGTTGGTGGTATTTACAT
TCCAATATGGATCTACTCAAATCAAGGTTG	AATTCCGAGAATTGGTAGCGGCGGATTAATTTACAT
TCCAATATGGATCTACTCAAATTGGGTGGC	GTAACCCAAAGCTTAACAGACCGGATCAGATTTACAT
TCCAATATGGATCTACTCAAATGAAAATGA	AGTCAATGCCCTAGCCCCGGCATTGCATTTACAT
TCCAATATGGATCTACTCAAATATCAGTGT	CGGTGCGTCTTCGGACAACGCAACTTTTATTTACAT
TCCAATATGGATCTACTCAAATTAATCGAT	TAAGTTCTTCAACAACATCATCCACGAAATTTACAT
TCCAATATGGATCTACTCAAATCTTCTAAT	TGCGATACTAGGTCATAGGCCTTTTGCATTTACAT
TCCAATATGGATCTACTCAAATCGGTATAT	GTAAAGCCGTTCGGGTGTTGGTAGCACGATTTACAT
TCCAATATGGATCTACTCAAATTTGCGCTT	TTTGTCAACGAGATTGATGGAGAAATGAATTTACAT
TCCAATATGGATCTACTCAAATTTTATTAT	AAGAATGAACGGGAAGTTATGGAATCGTATTTACAT
TCCAATATGGATCTACTCAAATACGATCAG	CCCCAACACTATTAGCCTGTTCAACTGATTTACAT
TCCAATATGGATCTACTCAAATAAAGTCTC	CCCGAAGCTGATAGCCTGATAGTTATTATTTACAT
TCCAATATGGATCTACTCAAATGACTATAA	AAATGTTGTTACTAACGTAAAGCCAAAATTTACAT
TCCAATATGGATCTACTCAAATGCGCTTAA	AAGCCCTCTTCAATTCAAATTTCCAAAATTTACAT
TCCAATATGGATCTACTCAAATTACGATTG	ATATACCGTTTATACTCTTTACTTTGAAATTTACAT
TCCAATATGGATCTACTCAAATTTGTAGTT	CGTCCATTGCCATTTTAACCGCATCGGTATTTACAT
TCCAATATGGATCTACTCAAATTCTTAATA	ACATTCATCTCATCACCTCATAGAATAAATTTACAT
TCCAATATGGATCTACTCAAATTTGTTTAT	TAATGATCAAGTGTTTAGCATTAAGATGATTTACAT
TCCAATATGGATCTACTCAAATAAAATGGA	GAATTAAATACAACTAGTTCACCATCATTTACAT
TCCAATATGGATCTACTCAAATGATTATAA	AGTAATGATAAATCAATCACTAAATTAACATTTACAT
TCCAATATGGATCTACTCAAATCCCCCATT	GCCTAATTCTCTTGCGCAAATAGCCCAAATTTACAT
TCCAATATGGATCTACTCAAATAAAATGGT	TGAAGTCGTATTAGAAGACGTTGGCAACATTTACAT
TCCAATATGGATCTACTCAAATTAAACTAA	ATACCGGCAGAACAGGACGCTTCCAAAATTTACAT
TCCAATATGGATCTACTCAAATATACGTAA	TCTCTATCAGTAATAGTGCCATACGTTATTTACAT
TCCAATATGGATCTACTCAAATACAAAATA	ACAGATAAGCCGCTGTTCTGCTATTGTAATTTACAT
TCCAATATGGATCTACTCAAATGCTAGCAG	AGATCAAAACCGTCGATGGACCTAGCAGATTTACAT
TCCAATATGGATCTACTCAAATCGTATTGC	CCTGAGCTGTCCAGGTACGTAAACTTATTTACAT
TCCAATATGGATCTACTCAAATTCTTTTGC	AAATCGATTGTCGTAACCGCTTTTAAAATTTACAT
TCCAATATGGATCTACTCAAATCAACCGGA	CTGGCCGCGAAATATTATTGTAGTTGATTTACAT
TCCAATATGGATCTACTCAAATGCATTACC	AATTATTTGGAAAGCACCTGTGAAAAGATTTACAT
TCCAATATGGATCTACTCAAATAAGAATTG	TTTCTTTTGCTTTTCTCATGTCTTCAAATTTACAT
TCCAATATGGATCTACTCAAATAAAATGGT	TGAAGTCGTATTAGAAGACGTTGGCAACATTTACAT
TCCAATATGGATCTACTCAAATTCGCCATC	GTCATTCCCAGTAACGACAATATCCGAATTTACAT
TCCAATATGGATCTACTCAAATATTTATCC	CGATATTGAAGCGGTTTTCATTGATACATTTACAT
TCCAATATGGATCTACTCAAATTAATGCAT	CGATAATCTCAATGCCGGCATTAATTTTTCATTTACAT
TCCAATATGGATCTACTCAAATAGAAATAA	ATTAGTTGATGAACTCAACACGAAATAATTTACAT
TCCAATATGGATCTACTCAAATAACAATCC	GGGTAAACCGATCCGGCGTCATAACAGTATTTACAT
TCCAATATGGATCTACTCAAATGACGATTT	AATTAAAGCTATTAATGATTTTGATTCATTTACAT
TCCAATATGGATCTACTCAAATTAATACTG	TTTATTTTTCTTTTCAGATCATTATAAGATTTACAT
TCCAATATGGATCTACTCAAATCGCCGGGG	CCTCTCCCAAGAGTAGGTCAGCAATCTTAATTTACAT
TCCAATATGGATCTACTCAAATCTTTTTAC	ATCTTTTAAGTTCATTTTTATTCCTCCCATTTACAT
TCCAATATGGATCTACTCAAATCCCGCATT	GACGCTATTATTTGTTATTTCTCTACTCATTTACAT
TCCAATATGGATCTACTCAAATGTTGACAA	AATACGCATTGCGTACTAGAATAAACGCAATTTACAT
TCCAATATGGATCTACTCAAATTGATAAGA	GTATTAACTTAACGACATCTTTAACAAAAATTTACAT
TCCAATATGGATCTACTCAAATCTTAACAT	TTTGATTCTTGATATTGTTCTTGCATTGATTTACAT
TCCAATATGGATCTACTCAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_016894.1\|WP_014357268.1\|3390627_3391653_-\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_016894.1\|WP_014357254.1\|3373772_3374453_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_016894.1\|WP_041669104.1\|3382827_3385083_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_016894.1\|WP_014357261.1\|3382311_3382806_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_016894.1\|WP_145972727.1\|3388567_3389311_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_016894.1\|WP_052307100.1\|3368580_3369531_+\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|234792
NC_016894.1\|WP_014357264.1\|3386219_3387098_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NC_016894.1\|WP_014357257.1\|3376335_3376959_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NC_016894.1\|WP_014357253.1\|3371245_3373780_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NC_016894.1\|WP_014357249.1\|3367805_3368384_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_016894.1\|WP_014357255.1\|3374550_3375393_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_016894.1\|WP_014357260.1\|3381303_3382296_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NC_016894.1\|WP_014357263.1\|3385103_3386189_-\|CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|187789
NC_016894.1\|WP_014357265.1\|3387100_3388552_-\|type-I-CRISPR-associated-protein-Cas8a1/Csx8	cas8b2	cd09744_cas8b2_CAS-I-B	gnl\|CDD\|187875
NC_016894.1\|WP_014357259.1\|3381012_3381291_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NC_016894.1\|WP_014357256.1\|3375389_3376070_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_016894.1\|WP_014357258.1\|3377077_3377641_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_016894.1\|WP_041669100.1\|3369737_3370154_+\|TOBE-domain-containing-protein	unknown	unknown	gnl\|CDD\|273189
NC_016894.1\|WP_193353286.1\|3389462_3390521_-\|hypothetical-protein	unknown	unknown	unknown
NC_016894.1\|WP_145972807.1\|3370200_3371103_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176112

Protein	Function_ID	Function_description	E-value
NC_016894.1\|WP_014357268.1\|3390627_3391653_-\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	2.31024e-30
NC_016894.1\|WP_014357254.1\|3373772_3374453_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.04911e-108
NC_016894.1\|WP_041669104.1\|3382827_3385083_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	3.50235e-56
NC_016894.1\|WP_014357261.1\|3382311_3382806_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.12258e-58
NC_016894.1\|WP_145972727.1\|3388567_3389311_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	5.31076e-14
NC_016894.1\|WP_052307100.1\|3368580_3369531_+\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	4.96897e-48
NC_016894.1\|WP_014357264.1\|3386219_3387098_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	5.44822e-54
NC_016894.1\|WP_014357257.1\|3376335_3376959_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	7.54899e-35
NC_016894.1\|WP_014357253.1\|3371245_3373780_-\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	9.57777e-11
NC_016894.1\|WP_014357249.1\|3367805_3368384_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.0516e-12
NC_016894.1\|WP_014357255.1\|3374550_3375393_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	8.00343e-45
NC_016894.1\|WP_014357260.1\|3381303_3382296_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.18508e-162
NC_016894.1\|WP_014357263.1\|3385103_3386189_-\|CRISPR-associated-protein-Cas5	gnl\|CDD\|187789	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	4.58212e-10
NC_016894.1\|WP_014357265.1\|3387100_3388552_-\|type-I-CRISPR-associated-protein-Cas8a1/Csx8	gnl\|CDD\|187875	cd09744, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as Csx8 family.	8.35206e-145
NC_016894.1\|WP_014357259.1\|3381012_3381291_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.06806e-25
NC_016894.1\|WP_014357256.1\|3375389_3376070_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.67312e-65
NC_016894.1\|WP_014357258.1\|3377077_3377641_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.97134e-13
NC_016894.1\|WP_041669100.1\|3369737_3370154_+\|TOBE-domain-containing-protein	gnl\|CDD\|273189	TIGR00638, Probable_molybdenum-pterin-binding_protein, molybdenum-pterin binding domain. This model describes a multigene family of molybdenum-pterin binding proteins of about 70 amino acids in Clostridium pasteurianum, as a tandemly-repeated domain C-terminal to an unrelated domain in ModE, a molybdate transport gene repressor of E. coli, and in single or tandemly paired domains in several related proteins. [Transport and binding proteins, Anions].	2.70018e-16
NC_016894.1\|WP_145972807.1\|3370200_3371103_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176112	cd08420, PBP2_CysL_like, C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold. CysL, also known as YwfK, is a regular of sulfur metabolism in Bacillus subtilis. Sulfur is required for the synthesis of proteins and essential cofactors in all living organism. Sulfur can be assimilated either from inorganic sources (sulfate and thiosulfate), or from organic sources (sulfate esters, sulfamates, and sulfonates). CysL activates the transcription of the cysJI operon encoding sulfite reductase, which reduces sulfite to sulfide. Both cysL mutant and cysJI mutant are unable to grow using sulfate or sulfite as the sulfur source. Like other LysR-type regulators, CysL also negatively regulates its own transcription. In Escherichia coli, three LysR-type activators are involved in the regulation of sulfur metabolism: CysB, Cbl and MetR. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.46297e-53

>NC_016894.1|WP_014357258.1|3377077_3377641_-|TetR/AcrR-family-transcriptional-regulator
MRISKEPEVRKQEMIDTAMKIFAQKGYEATSMTDIAKEMNVVSGLCYRYFKSKNELYETAVKMYAKACSEPMIQILSHEGMTLQEGFERFSRSFIVSDGAEKYHEFFHREGSERFHRHLESEMLKNIMPYMIKYLADLRDRGEIQIDDIENSAKFIMYGQMPIINDEQLSSKEKTDKVIYLIKKVLA
>NC_016894.1|WP_014357257.1|3376335_3376959_-|class-I-SAM-dependent-methyltransferase
MNNEKVKELTQKHFDETAGDYNTSHDGKFVKCMYDEILERIVAINPETVLDLGCGNGNVLKKIMDISNAKLFGLDLSPKMIESAQKKLGEKVTLEVGDAEKLPYAENQFDIVICNASFHHYPNPDRVLSEIKRVLKNGGILILGDPTAPFEWYLKILNWGLKWSNSGDFRIYGAKEITALLSKNGFQVSGWKKIKNRAFVINAISEI
>NC_016894.1|WP_014357256.1|3375389_3376070_-|response-regulator-transcription-factor
MKHILIIEDDIALNNGIALALKDADYCFHQATTLACAKELMLNQKMAMVILDINLPDGSGFEFLEVIRKDSDVPVIILTANDMELDEVRGLNLGADDYITKPFSLMVLRSRIESVFRRSVKQNKNIYIIDDLYLDFEQMFFKVGDRELGLSKTEQKLLFLLVENKDRTVTRGVLVDKIWTNAAEYVDENALSVAISRLRNKIEKDPGTPQYIQTVYGLGYTWGKKT
>NC_016894.1|WP_014357255.1|3374550_3375393_-|HAMP-domain-containing-histidine-kinase
MSIFGTRKTLNRLNEMIDDAIAGNFTESNYDESQLSRLESKWMHYLSASKMSMVQTNQERENIKSMVSDISHQTKTPLANILLYTELLNEQVDNQENLKLVEQISMQTQKLDFLIQSLVKMSRLESNIIELNPQKQPVKPLLEQALSEIMPKARQKQMDITVENAEAIQACYDLKWTSEALYNILDNAVKYSEAQTSITIHVKMYELVTCIAVEDQGSGIAPDEKAQIFQRFYRSSGIQQKEGIGIGLYLAREIMQKQKGYIKVTSTPKKGSIFSLYLPT
>NC_016894.1|WP_014357254.1|3373772_3374453_-|ABC-transporter-ATP-binding-protein
MTILQTRNLRKEYGNGDNLVKALDDVNLTIKQGEFVSIVGTSGSGKSTLLHMLGGLDRPSSGKVFVEGNDIFSFKEEPLTIFRRRKIGFVFQSYNLVPVLNVYENVVLPIELDGNTVDDEYIHEIIDILGLASKEENLPSQLSGGQQQRVAIARALAAKPAIILADEPTGNLDSRTSQDVLSLLKMTGERFKQTIVMITHNEEIAQMADRIIRIEDGKVRERGEND
>NC_016894.1|WP_014357253.1|3371245_3373780_-|FtsX-like-permease-family-protein
MIKVTNKKAIRNLAYKSFKNNKIRNYIAMIAIALTTVLFTTLFTLGMGTVESIQQATKRQAGGDGHAVVKYINDDEFNTIKEHPLIKEIAYDRILCDDIENQEFLKRRAEFWYDDDIGLKLGFIELASGHKPVAENEVIADTKTLQLMGVPLEVGAPLTLTLNIRGETVTRDFVLAGWWESDPVFNVGQIFASRAYVDAHLGELQNTYKEDNSMTGAIQAYIMFDNSLDLENKLATVITESGYSFDENAPNYLASNVNWSYLSTNFEMDAQTWIALIAALLLIVLTGYLIIYNIFQISVIRDIRFYGLLKTIGTTKKQIRVMIRNQALLLSVIGIPVGLIGGFVIGVALVPLVMSNTTYAGSAVSVSPNPWIFAGAALFALITVMISTFKPGKIAGSVSPVEAVNYTDSDKKNSATNKKSKDGAKIHRMARANLGRNKKRTLLVVLSLSLSLVLLNTVFTLSTGIDMNKFLSKFNDADFLIAHADYFQYEYFGNENQTTETFIEAVQTQPGFQQGGRLYGGRDELFTCTDNSVDIINTNEYGDHYAAVYGLEDFPLNRLVVLDGELDYDKLASGKYILEGVQLDDNNNPEFESSHYDVGEVVELHNYKGTSESFEEREYTTQQFTVLAHVAIKYYVNSDCTGWAYSFYLPANIYKTLVTKPAVMSYTYNVADADEATMERFVANYTDTVEPLMNYTSKLTSLASLSEMKMTVVMVGGALSLIIGLIGVLNFINAVVTSIITRRKEFAMLQSIGMTQKQLRNMLCYEGLYLTLGTGIVALFFGSLFSLVVVNFFSGLIWFLGYQFILWPLLSVLPFLLVMGIAIPWIADMATNNQSIVERLRDAD
>NC_016894.1|WP_145972807.1|3370200_3371103_-|LysR-family-transcriptional-regulator
MTIRHLKIFITVYDERSMTKAAKKLFMTQPSISQVIKELENYYNVILFERLSHKLYVTKAGEKLYTVARQIINLLDEAKDTLGIADLQKNLAIGVNYTIGSKLVHRYIQKYERLYPGSEISVNVNKAPKLIEMLRNGELDLALIEERDNEADLIQKFFYHDRVVIIANPKHALCQKKYVNPEDIINEHLLLRDRGAGVRNLFELRMKELGLGIKPYWESTSTTALISAAENNFGIAVLPFQLVQEKIDNGSLKEIKIKGMDLDRKLMIAYHKNKFLTSSMLEFVKICHQTEEIKSLQLAK
>NC_016894.1|WP_041669100.1|3369737_3370154_+|TOBE-domain-containing-protein
MKLSARNQLSGKVEAVQEGAVNAIVTLKTDDGTTISSTISLAAVKELGLAVGKEATAIFKATEVLIGLGTMKISARNKIIGEVAAVEAGAVNGIVTLKADTGCTISSTISMAAIKELGLEPGVKATAVIKATSVMIAV
>NC_016894.1|WP_052307100.1|3368580_3369531_+|GIY-YIG-nuclease-family-protein
MNQLKEKLKQLPSLPGVYKMLDSTGQIIYVGKSNCLKKRVSSYFTPSPKPAKIEKMILFINDIDYIVTDTHLEARLLECQLIKTIKPYFNAQMKNDKRYFYVKVGHSRQAHVLSIVPERDADTFGPFRRKQLIQSMIDSFTYLFPIVKKNNHYDFIYQTLPQIMSVEDFMNNKQTLMEIFLEENKMLSLINQLQLAMREEAAHYHYEKAARYRDLVNGLTNINHVLHDYKRLLEKDILLKIPVRDGEKLFYISKGQIILKKYFRALSPIEIDKFLAEANNIKAALIINRNEKAEIDFQNILFSELQALPDDWILLK
>NC_016894.1|WP_014357249.1|3367805_3368384_-|TetR/AcrR-family-transcriptional-regulator
METKRQLQKAATRKLILDTAYQVYAEQGFTATTNKIAQAANVSHGTIFVHFPTVENLISCLLEEFGIEINEQLHSLSEQDENLETFLDAHITILIRYEKFYQRLISEISLLPEQARFIYINMQSVVSFHLNNVLIRYQTKNLIKDIPMHLIFNTWLGLLHYYLSNSFIFTTGSVLTEFKDELISNYIKLIKK
>NC_016894.1|WP_014357259.1|3381012_3381291_-|CRISPR-associated-endonuclease-Cas2
MYVILVYDICGDEGGQRVLNKTFKICKKYLNHIQNSVFEGEISEPQILNLKYELNKYIRKDIDSVILFKSRNERWLKKEFWANVEDKTDNFL
>NC_016894.1|WP_014357260.1|3381303_3382296_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MKRDYYFYNDGTIRRKDNTITFINSDEESRNLPIENMGNLYVMSEMSLNTSLINLLSQYGIVVHFFNYYSFYTGSFYPREKLVSGNIIVKQVEHYQDNEKRMGIAQALIDAASYNIYRNLRYYNGRGKDVKMEMADIENLRKNIAGTIGIKELMGYEGNIRKIYYSAWDKIIDQDINFTKRVKNPPDNMINTLISFVNTLVYTKVLGEIYQTQLNPTISYLHEPGTRRFSLSLDIAEIFKPLIADRLIFSLLNRNQITEKSFAKNLNYLHLTKEASKTIVSELDAKLQTTIKHRELDKSVSYQYLIRLECYKMIKHLLGEKEYEAFKIWW
>NC_016894.1|WP_014357261.1|3382311_3382806_-|CRISPR-associated-protein-Cas4
MEKEITGVMVYYYQVCWRKLWYFYHEIQMEQNNDNVQIGKLLDENAYGRDDKHINIDNIINIDFIRTKKVLHEVKKSKKIEAASILQVKYYLYFLMKRGATGISAQIDYPLLKQSVEVSLSDQDVAEIEKILADISKIVKEENPPVLKKLRICKSCAYYDLCYI
>NC_016894.1|WP_041669104.1|3382827_3385083_-|CRISPR-associated-helicase/endonuclease-Cas3
MKNPEDYQAKPDKTIKEHSLELIDELDRLNNLGYIKNDQIYELTKKACWYHDFGKANKEFQKRVMSEKKIRMSLEREVFHNILSVFLIQPDAFESKDDYYKVTQAILFHHDYAESYEDVYDQLKSRKELCTALLNEFPLVPIKNRLQLELIKRIEDDQVVKIKGLLHKCDYSASGGFVAEYPNDFLESGLENLGYDWNDLQKFCIDHRNENIIAVAQTGMGKTEAGLLWIGNYKGYFVLPLRTAINAIYQRIVGDETKKIVSEKLDERVALLHSSSLSYYLEMAEKNKKELVEMGMDGIDVEEYQKRGHQHSIPLNISTMDQLFDFVFKYQGYELKLATLSYSKIVVDEIQMYDSDLLAYLIMGLKRICELGGQVAILTATLAPFVEDELKMAIPGIIKQGFYDNSLRHNLKVKDEEICIDDILAHYTANKDSGIGNKILVICNTVKKSQEVYEKLRQSGKVENDEVFLLHSKFTRGDRAKKEEAIKNFGKTYVGDSHEIDVRNGIWVSTSLVEASLDIDFDYLFTELQDLNSLLQRLGRCNRKGVKSIDQTNCYVYTVINEKLFIINGHGFIDSDIFNISKAALSQWDGPISEKQKLTLINDNLTTEKLKKSNYYKAYKSKCDWIASIAAYTIKQKEIDLRHIFSEEIIPSPIFERYRDKITKLVEQINQPNMERKEKLRLKELLYQYTLSVEKYHVTNYEKAKFKGEALTFEPLRIGKFETIQVLECSYDESLGFRKLEKSQIRNPEFL
>NC_016894.1|WP_014357263.1|3385103_3386189_-|CRISPR-associated-protein-Cas5
MKALRIKLYQSSANYRKEESDTNKMTYPLPPFSTVIGALHEASGYQTYHPMDLSIQGKYESMHREPYTDYCFLNSTMDDRGILVKMRNPELLSSAFDKVAAAQKSQGNSFRKRITIKVFDEILYQEFIALKELNDEIENFKNTRYKRIMDLIKTRKKTIKIKKTEVSKGEIQYEKLCRREKQIKEIEKQIKDEFEKYKEVQYTKPYSKFRSLTTSLKFYEILNNVELVIHVKAEETVLMTILDNIYHLKSIGRSEDFVEVTEAKIVELIQDDNCDVTSSFSAYLDFRDVKNERIFPVAVGGGVNEKGGTRYGLNKTYQIIDDKRIFDKKSVIYLSQYGIDETSETIWLDRDDDQEYIVNFI
>NC_016894.1|WP_014357264.1|3386219_3387098_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MKKALTLTVVANMTANYSEGLGNISSVQKVFKNKKVYSIRSRESLKNAIMVQSGLYDDLQTEVDGATQKLVTEKLTAANCKALEGGYMSTKGTTYIRKSSFYLTDAISTDNFVNETRFHNNLYLASTEAKQKGINLQEKSKESGLMPYQYEYDKSLKVYSFTMDLEMVGKDENFNAEATSAEKANRVIAIVEAIENLSLVVKGNLDNAEPVFVIGGLSPRKTHFFENVVRVQGEKLIISDDLLGKLEKGFNCGLLRGNEFLNEEEIVEKLKPQNMTAFFNDIKSEINNWYGV
>NC_016894.1|WP_014357265.1|3387100_3388552_-|type-I-CRISPR-associated-protein-Cas8a1/Csx8
MVEEFVIDEKSYFKLSATEWRYSAAALGLMRYFDFLEIPWIEKAFDVLSLPEIAKELQKSIVCVYERSTGFEYLCFAKEYLSEEDYLRFVREIYPNDLYPFLIEEQLKKSVFEEAEIKEINTWLTGNTVMKKIFGKTKFTGENKDEILTIIKANKDLSTKESFRYKKNLYANYANTHQLLNEGGDSCRLSGYSIDMGKKGRSTAYNFNVKTSTNMDTILFDWIPFAFIGDREAFFINANYDLKQLKKINTFLRTQVKKDRDDDKNKNQNVRYSLFNSMIFSSQFINFDVEVIYKNRERDFFETLYIRHESMEILKSMDKINYKAFCFSLKINDNYYIDIQEKITNCILNLVLTDELIELFLKQKNSNGYLVSQCIEINWLIRKGGEVMKKKMSGAYACAKEVVKKIPENKIESYRQRLTSAIVFKDYDRVCQILLQLSNYSNVSFNFAYDLFEDFENNKDIAYTFINALRKGNDNTSNNEGGN
>NC_016894.1|WP_145972727.1|3388567_3389311_-|CRISPR-associated-endoribonuclease-Cas6
MKLELNFSLKSMIIPLDYRKVFIAFIKKALTEAKGGEYFEKFYRDTLAKSFSFSVVFKQPDFKKDKIILGANQLKVLFTAIDDAQVSLIMYMAFIEQKNKAFPLPFENEMVLRTIYEKKAEKIETNKVIFKTAPGSGLCVREHNRETNGDNYYVFNDEAFTEKLFTVLRSQAERAGFNKQVAEKIRCKPLNCKKVVVKHYGCLLNISIGMLQMEADVKLLQYFYDAGIGSRHSAGFGLVDLVAQDLF
>NC_016894.1|WP_193353286.1|3389462_3390521_-|hypothetical-protein
MKTAKLVIGIISMVLSFFIMFQSCAAGIVNTVASNGEMSGTAGLMVAVFFIIAGIVGVATRNSLGMAGSLTAGGFYLAAALIGSITAGNYTDLYIWSFLAWSFGVVYLVAAFYDQYDIWGAASWWQKSWFIILITIVFPPAGIALVWISRKFELAPRIIMTVIFSIAFLISMASFMGIANTSANKPINMNNTNNTNNTNNTNTNTTTDSKVTEDTQKNKVYGLGETWTVDGEFSLSFTAVTATDDRNQFSEKTPGQVVILNYDYSNIGVEKSFTELYISSNDFNVIDANGEVASTYPASIAVHPQETPIGAKCVGAQCAYGLNNPSSEITVKVQVNGNNFKSYEAVFKLPVQ
>NC_016894.1|WP_014357268.1|3390627_3391653_-|WYL-domain-containing-protein
MANTKMKILRVLDILKETDEHHPITANEICHKLETYGIEAERKSVSRDINVLMEYFNNDSDYGYEIVLCEDNRKGYYMCSRLFEDWELKILIDAVWQARFLTAKKSESLANRLGSLASTESRKVLQNVTPVKSYIKTTKPKISEHIDMLLLAIRKGRKVEFQYQYTDTNMEKQLRFEGKVYLFNPYALKWRGDRYYLIGNYDKYDNLSFYRLDRIYNLAITDSRVKPVREIVGDNSANKIEAYVSKCMYNFGGENIHPVLRVKAEMVDEIIDYFGEDIQFKKQEDNYFDVRVSVNDGDGLYFWLLQYAEKVKVISPKSVRNELLKRVHAIIKNYDENESTN

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Crispr_ID: NC_016894_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016894_3

3904684-3905123

Orphan

Consensus_repeat	Method
GACGTAACACTGCTGGGTATCGTTAT	CRISPRCasFinder

6 spacers

The CRISPR arrays of NC_016894_3

>merge|NC_016894|3|3904684-3905123|CRISPRCasFinder
TCCTCGACACTGCTTGGTATTGTTATATTGGTTAAGCTAGTACAACTATAGAATGCGTCTTTGTCAATAAACGTAACACTGCTGGATATCGTTACGCTACTCAAACTAGTGCAATCTGCGAAAGTTGCGTCTGCAATAGATGTAACACTATCTGGTATTTTTATATTGGTTAGGCTGCTGCATACACTAAATGCATGCGCTCCAATAGATGAGACACTGTTTGGCATCGTTATATTGATCAAACTACTGCACCGATTAAATGCGTAGTTTCCAATCGACGTAACACTGCTGGGTATCGTTATATTGATTAAACTGCTACACCGATCAAATGCGTAGCTTCCAACAGACGTAACACTGCTGGGTATCGTTATGCTGGTCATTTTATTGCAATTAGCGAAAGTCCCTTTTGCAATAGATATAACACCGTTAGGTATGGTCAC

>NC_016894|3|3|3904684-3905123|CRISPRCasFinder
TCCTCGACACTGCTTGGTATTGTTAT	ATTGGTTAAGCTAGTACAACTATAGAATGCGTCTTTGTCAATA
AACGTAACACTGCTGGATATCGTTAC	GCTACTCAAACTAGTGCAATCTGCGAAAGTTGCGTCTGCAATA
GATGTAACACTATCTGGTATTTTTAT	ATTGGTTAGGCTGCTGCATACACTAAATGCATGCGCTCCAATA
GATGAGACACTGTTTGGCATCGTTAT	ATTGATCAAACTACTGCACCGATTAAATGCGTAGTTTCCAATC
GACGTAACACTGCTGGGTATCGTTAT	ATTGATTAAACTGCTACACCGATCAAATGCGTAGCTTCCAACA
GACGTAACACTGCTGGGTATCGTTAT	GCTGGTCATTTTATTGCAATTAGCGAAAGTCCCTTTTGCAATA
GATATAACACCGTTAGGTATGGTCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016894.1\|WP_169314719.1\|3911635_3911746_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380007
NC_016894.1\|WP_014357740.1\|3911883_3912087_-\|hypothetical-protein	unknown	unknown	unknown
NC_016894.1\|WP_014357731.1\|3898129_3898597_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|173926
NC_016894.1\|WP_041669499.1\|3892526_3893228_+\|lantibiotic-protection-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|163452
NC_016894.1\|WP_014357733.1\|3905420_3905669_-\|DUF2442-domain-containing-protein	unknown	unknown	unknown
NC_016894.1\|WP_014357723.1\|3888419_3889388_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_016894.1\|WP_014357729.1\|3894729_3895404_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_016894.1\|WP_014357737.1\|3909921_3911073_-\|DUF924-family-protein	unknown	unknown	gnl\|CDD\|377592
NC_016894.1\|WP_169314717.1\|3909259_3909646_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369940
NC_016894.1\|WP_014357728.1\|3893985_3894714_+\|lantibiotic-immunity-ABC-transporter-MutG-family-permease-subunit	unknown	unknown	gnl\|CDD\|163445
NC_016894.1\|WP_014357744.1\|3916128_3916794_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_016894.1\|WP_145972736.1\|3897012_3898133_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_016894.1\|WP_014357725.1\|3890224_3892222_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239241
NC_016894.1\|WP_014357727.1\|3893227_3893989_+\|lantibiotic-immunity-ABC-transporter-MutE/EpiE-family-permease-subunit	unknown	unknown	gnl\|CDD\|274754
NC_016894.1\|WP_014357734.1\|3906051_3908538_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225461
NC_016894.1\|WP_169314718.1\|3909680_3909833_-\|hypothetical-protein	unknown	unknown	unknown
NC_016894.1\|WP_014357742.1\|3912901_3914134_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223717
NC_016894.1\|WP_014357743.1\|3914135_3915842_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|237198
NC_016894.1\|WP_014357730.1\|3895379_3896711_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_016894.1\|WP_041669496.1\|3889472_3890066_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NC_016894.1\|WP_169314719.1\|3911635_3911746_-\|hypothetical-protein	gnl\|CDD\|380007	pfam17761, DUF1016_N, DUF1016 N-terminal domain. This family may include an HTH domain.	0.00854984
NC_016894.1\|WP_014357731.1\|3898129_3898597_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	0.00588383
NC_016894.1\|WP_041669499.1\|3892526_3893228_+\|lantibiotic-protection-ABC-transporter-ATP-binding-protein	gnl\|CDD\|163452	TIGR03740, galliderm_ABC, gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit. Model TIGR03731 represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family describes the ATP-binding subunit of a gallidermin/epidermin class lantibiotic protection transporter. It is largely restricted to gallidermin-family lantibiotic biosynthesis and export cassettes, but also occurs in orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes.	1.48516e-119
NC_016894.1\|WP_041669496.1\|3889472_3890066_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.84138e-14
NC_016894.1\|WP_014357723.1\|3888419_3889388_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.40861e-25
NC_016894.1\|WP_014357729.1\|3894729_3895404_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.04326e-76
NC_016894.1\|WP_014357737.1\|3909921_3911073_-\|DUF924-family-protein	gnl\|CDD\|377592	pfam06041, DUF924, Bacterial protein of unknown function (DUF924). This family consists of several hypothetical bacterial proteins of unknown function. Structurally, this family resembles TPR-like repeats.	6.01836e-80
NC_016894.1\|WP_169314717.1\|3909259_3909646_-\|hypothetical-protein	gnl\|CDD\|369940	pfam08546, ApbA_C, Ketopantoate reductase PanE/ApbA C terminal. This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.	1.31582e-30
NC_016894.1\|WP_014357728.1\|3893985_3894714_+\|lantibiotic-immunity-ABC-transporter-MutG-family-permease-subunit	gnl\|CDD\|163445	TIGR03733, lanti_perm_MutG, lantibiotic protection ABC transporter permease subunit, MutG family. Model TIGR03731 represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family is largely restricted to gallidermin-family lantibiotic cassettes, but also include orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes. In most species, this subunit is paralogous to an adjacent gene modeled separate by TIGR03732, while in some species only one subunit is found.	1.35581e-32
NC_016894.1\|WP_014357744.1\|3916128_3916794_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.32532e-07
NC_016894.1\|WP_145972736.1\|3897012_3898133_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	4.69658e-44
NC_016894.1\|WP_014357725.1\|3890224_3892222_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|239241	cd02931, ER_like_FMN, Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and methylketones. ERs are similar to 2,4-dienoyl-CoA reductase from E. coli and to the old yellow enzyme from Saccharomyces cerevisiae.	9.36425e-169
NC_016894.1\|WP_014357727.1\|3893227_3893989_+\|lantibiotic-immunity-ABC-transporter-MutE/EpiE-family-permease-subunit	gnl\|CDD\|274754	TIGR03732, lanti_perm_MutE, lantibiotic protection ABC transporter permease subunit, MutE/EpiE family. Model TIGR03731 represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family is largely restricted to gallidermin-family lantibiotic cassettes, but also include orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes. In most species, this subunit is paralogous to an adjacent gene, modeled separately.	3.41938e-39
NC_016894.1\|WP_014357734.1\|3906051_3908538_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	1.4183e-22
NC_016894.1\|WP_014357742.1\|3912901_3914134_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223717	COG0644, FixC, Dehydrogenases (flavoproteins) [Energy production and conversion].	8.0986e-27
NC_016894.1\|WP_014357743.1\|3914135_3915842_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|237198	PRK12771, PRK12771, putative glutamate synthase (NADPH) small subunit; Provisional.	1.97286e-111
NC_016894.1\|WP_014357730.1\|3895379_3896711_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.6691e-35

>NC_016894.1|WP_014357731.1|3898129_3898597_-|GNAT-family-N-acetyltransferase
MALEIRKLIPDLAEDYVHFFDTTPHDNNVDDHKCYCVCWCNDDYEGKDFSTAEKRRKCAIQYVKGNNIQGYLAYSGDTVVGWCNANTKLDCLKCVSWRKFMNYVPIEKSDSGIKVKSIFCFVITPGMKRKGIATLLLERVCTDAKQDGFGLSTLF
>NC_016894.1|WP_145972736.1|3897012_3898133_+|IS3-family-transposase
MTKRPRRSFTDEFKNQMVQLYLNGKPRSEIVKEYDLTASSLDKWIKQHQSSGSFKENDNRTDEENELIRLRKENQRLLMENDIFKAGSADHRTKVEVIRANQDRYSVSAMCRVLNIPKSTYYYISKKTNGVDPIIADVIEIFKMSRKNYGTRKIKHQLEVKGIVASRRRIGRIMRENGLVSNYTVAQYKVHKQPVNQDPVPNEVNREFNGRAPLEVAVSDLTYVRVGGKWNYVCLIVDLYNREIIGYSAGPNKTAQLVYEAFARIRYRLDQISIFHTDRGSEFKNNVIDGVIETFNIKRSLSNKGCPYDNAVAESAFKVFKTEFANQYAFDRLDYLKLMLSDYVNWYNNIRIHSSLGYLTPDAYRKLAHKKSV
>NC_016894.1|WP_014357730.1|3895379_3896711_+|HAMP-domain-containing-histidine-kinase
MAKKQRSISLSLVLLRFAIVMLGSMVFCCLLWYLCFWRLENADVICQSFVAYQQVEQMLAGEPKTFISPGDNFIAEYALFDQNGNVLESNVTAKKLEDLTEFLSVATPNLNVLRYPYADGSTVIFHWYYRAEFVDPLLRGMLPPFEYLWMATLGIVWVFCLLFNTLWLRRFLAAKLKLFGEVSAKIGAQELDFTIPHAGIREYDQALDAMEHMREALYQSLSDQWATQQKREAEIAALAHDLKTPLTLVGGNAELLLDEELPERSRKMVATIVASNDRAKHYLVSLLETSAGADESFKDTSLPTMFNELCQRTMTIAETRRICLHTQNELLGAANIQKDHLLRALANVIQNAIEHTPAGKNVYLEGRMADNGWQITVCDEGPGFSKAALHHATERLWRDDPARGVDGHNGLGLWFAAQVVKTHAGQLELQNCDSGGVVTIKFC
>NC_016894.1|WP_014357729.1|3894729_3895404_+|response-regulator-transcription-factor
MSKLLVVDDDLEMLSLVRAALEKDGHQIDTEADAAIVQPARCQLYDLLLLDVMMPNEDGFSLCRRIRAEVDCPILFLTAKAEDAALVQGFGLGADDYIKKPFSLAELRARVNAHLRREVRQPTHTLSRGGVRFDMQAKVAIAGEHPLPFTKGEYAICEYLALHAGQVFTKEQLYEAVFGFDAEGDPSAVAEHIKNIRAKLKSDDINPIKTVWGVGYKWQKNNVL
>NC_016894.1|WP_014357728.1|3893985_3894714_+|lantibiotic-immunity-ABC-transporter-MutG-family-permease-subunit
MTILREFFSNFTKIKRTPVILLHLLPPIVITTLFFVYYASGGYHLISDVRLFFVILQIGYPIFVSIVVPILINLDRHNGIQNALGLVPSRSSVYLGKWLFLMFLSAINMILYEVCFYVGVNFFPGINMPPFGASLVIFGVFLFSNLFLYLLHILIAFRFGSSLSVLTGISGTILAGYFENAIGDKIWPFIPWEWGVRFLENYFNFSNVPVFPGIIALMIMTSFILIVSLLWFSHWEGNVIQE
>NC_016894.1|WP_014357727.1|3893227_3893989_+|lantibiotic-immunity-ABC-transporter-MutE/EpiE-family-permease-subunit
MLQAYLNAENLKFKHSLFRKLILFIPAALILISLVFIFVGIGLGGFSSAMVCNWCMPIGSLSVMFLCHLVNNKDQKHGYRTLYSLPIDLKQIFIAKTILIALNLLIISLLLSFITVIAESIVSGLFIALSHSDYYLLGYGLLWLSLLWQIPFCLFLDQKVGFVAAVIINLFASAFGGLFFSLTPLFWFFPYSWPARFMVTLFGVLPNGLLVNGGSRLILNPGASALLVLISLLTSLLLTVLFSRWYRKQVYRK
>NC_016894.1|WP_041669499.1|3892526_3893228_+|lantibiotic-protection-ABC-transporter-ATP-binding-protein
MSEYILKTNHVSKKFKQTDAIKDLSMSVRKNSVYGLLGPNGAGKSTFLKMVTGIIRPTSGEIIFNNHPWTRKDLLNIGSLIESPPLYENLTAFENLKVRALLLGISTDRCHQVLQQMDLMATNNKKVANFSLGMKQRLGIALALLNNPQLLVLDEPTNGLDPFGIEELRVMIKNFAASGIAVIISSHILSEIQQVADDIGIIYNGSLLYQDKIDAHKNLEQLFMDIIRKERAS
>NC_016894.1|WP_014357725.1|3890224_3892222_+|FAD-dependent-oxidoreductase
MKSKTDALFQPMSIGTMRVKNRIAMAPMGLHSKNPDGSFNQDAVDLYVARAKGGVGLIVTTGIACQNKLDSMRATLATAGDSYVTASKKLTDEVHKYGAKIVLQIANGAGRNRKNGFFLDNDPISSSENPNVWHPEMMHRALTTAEVQFLIQSYANGAYVAKQAGFDGVEVHALHEGYLMDQFSMECTNRRTDQYGGSLENRLRYATETVQAIKEKCGKDFPVLIRYSVKSYMKGFGLDKGALPGEKFEEFGRDLEESAKIAKILQDAGYDALDADNGTYESWYFAHPPVYMPKACNLADAQYIKQFVDIPVICAGKMDDPEIGSEAVASGSIDAISVGRALLADPEWPNKVQTENFDDIRPCIGCHAGCLERFFAGKNTSCAINPQVGMEKKYEIKPADVKKNIMVIGGGISGMEAARISALRGHKVDLYERTNSLGGVFIPASSMSFKEEDKKLIQWYVKQLKDTGVTIHMNTEVNENIIKAAKPNSIFVATGSTARKLNINSASSEKVITAVEALLETKPIGDKVVVIGGGLTGVEIGYSLTKDKGKHVEILEMLPDILQVQDLNAANKTMLQNLVLSHNIGVHTNAKVTAITSKGVQFEENGATVELDADTIITSIGYISDKSLYEAIHDCGAEVYLIGDASKVSNLMGAIWDAYEIAMAI
>NC_016894.1|WP_041669496.1|3889472_3890066_-|TetR/AcrR-family-transcriptional-regulator
MIENIKHTILVKAIELFKKNGFDNVTINEICESCNITKRTFYYHYDSKKTLLLDYFSLVDEDIETSLKDIDNEITWLDKCWKIKQIHIKGIANLNTDILKNLIKIDMEQQNYMFNFRLNDFDPNLKRLRQMVIEYTYKAQETGELDADTSAEDLSYCFASAFLGLAVNWSSTGGNYDLVEAAKKYFDLIYKKTSRSK
>NC_016894.1|WP_014357723.1|3888419_3889388_+|helix-turn-helix-transcriptional-regulator
MYEWHQQIQTIVDEIDNCIKNYNGEALTLHFLSHKLGYSEFYTTRKFKEIAGMQFRDYLRHRKLAFALKEVRDRNKSFLDIAFDYGFSSHEAFTRAFKGTYGVTPSEYRKKPTPVILRTKINPFDRYFFGFGEIGMIKSTADVKIYFVTIPAHKFLHIKNYQSNGYWDFWQKQNLIPGQDYETICGLLDSIKGKLDDDGGSESNSGSGQLMAYINDPNGRLCDWGIPRTECYGARLPFDYNGEIPSQMLMLDVPEAEYIVFEHGPFDYEQENRSVEATMEKAMATFDFSGTGYCFDPSPGRIIYLLYNPERFWKYIRPVRSK
>NC_016894.1|WP_014357733.1|3905420_3905669_-|DUF2442-domain-containing-protein
MKITNVYATDDYKLLIDFEEGNQVRFNMQRMVETIPFLRLRDLEVFKDVKFEDKAVCWDAPDGKPEVMPLRMTVDNILFALR
>NC_016894.1|WP_014357734.1|3906051_3908538_+|LuxR-family-transcriptional-regulator
MKNKKILNRDRINTMLSAVYDYPLTILEAPMGYGKTTAVKRFIEQKNLHTCWFTFSDFKNSETAFWDSFANAIITIDTQAGTILKSLGLPTDAPQMGKVLQTLDSLDFDGTFLIVLDDYHLAGDMRLNRLFLRLAQEELEGFSILLITRDTTGLDFIELLSKGQCCLLPKQLLQFTQGELQDYCRMMLTDITDTDQQMIWQYTDGWISFAYIILLGLESGIPIGMSTNLENMIERTLFAPYDEKTQGFLLLLSVMEDFTAEQAAFVTQQEDAPQLLKRLDMENAFIYYEEKTGIYKIHAVLQNFLRIKRHLSTDDLQNLYGRLGDWMMSQQNLLAAYSYLNRAGRSEDILAHLNNPKNIRNEWLDFEGADELFNRLPRELLFQYPFAYLLHMFYSILLGKENEILGWNERLDELQQYYKNMAGLEETYRNRILGEILIVRKFTRFNDVAAMCASDAEIIRLLNGQNSYITLPENEFTFASPHYLYLYYRDKGSFCKLANLLSEDVGYAKFSGGCGTGSDALTLAEYALETGDLNNVASHCRKAIAKAEIMSQTGIVICAKFSLIRLRLIEGNVSQALHLLTELERHVEKMNNSVYNTTIDLCKGYVFACLGRPEQIPTWLQIGEIKAADFYDQGIAFNYIVYGKTLLALEKYDELESRIEQFEAYFSVFCNRLGLIHNQIFEAVARCRLYGLEEGASVLLVALDEAQADNLVLPFAENALHIMGMLKIIIQGNPGNTFFNHILMLCCRYESAIMGLPHPVATLSRREINILSLAAEGLSRKEIAARLYIAEGTVKTHFKNIYQKLGVNSKMAAVKIAQNRGYLSMTEW
>NC_016894.1|WP_169314717.1|3909259_3909646_-|hypothetical-protein
MDRKIWSKFMLNIGVNQVVSVYGQNFGSVKKPGRARDMMIAAMAEVIPVAKQEGVVLDEADIAYWLGVVDALSDAGKPSMRQDVEAKRPSEVALFSGTVVALRQKHRIKTPVNAMLYDNIMAIEKGYV
>NC_016894.1|WP_169314718.1|3909680_3909833_-|hypothetical-protein
MEIKKQQSLAWMPWLFFSEPRLSNKSGMICFGNRADDQSNEKVMRVKRFF
>NC_016894.1|WP_014357737.1|3909921_3911073_-|DUF924-family-protein
MYKISELTVADYLVKMSVCDFPGPAAGSAAATAAAMAAALLEMSCDGSLRKSGDNLLLVESIAIGAELRQACLMLADVDMMAYGQVIAAAKNKAGDREAYETAMKGATEPFIQILRHCHRLLDQIEKVIKGSFSRVLGDLVGGAYLAEAAAAASKSGIDVNLRLIHDEAFQNRYQAEANALYRACASLKAEILNQVFSSSRGIHSDAKAVLDFWFEPQNQPFWFQKNQAFDLAIKTNFYDHWVAGCNGLLSDWRDTIEGRLAEIILLDQFSRNLNRDNPKAFAQDGMALVLSQEAIHHPDFNRLPQAWQRFMLMPFMHSEAADIHQVALPLFEALGDPATLEYEIKHQQIIDQFGHFPHRNEILKRESTPAEIEFLKQPGSSF
>NC_016894.1|WP_169314719.1|3911635_3911746_-|hypothetical-protein
MYATVDIVMVVTYWNIGKQTYETQDEYERVEYGICT
>NC_016894.1|WP_014357740.1|3911883_3912087_-|hypothetical-protein
MVRQVGSSIGIAILGTIFFGTVGNLSGITGFVMGIRYAILSAVGILILTIPLVFLFPKKAQQHSDTF
>NC_016894.1|WP_014357742.1|3912901_3914134_-|NAD(P)/FAD-dependent-oxidoreductase
MKRQIIVVGAGPGGSTAAFYFAKKGMDVLLLDRETWPREKPCGGTYLPVCYPMFEEMGVLEEMQSVAEMSATKVRLILHDEANGEFTTKPKLNMPRRYGDDCIRRSALRAGADYMENFDVTELIMRKGVVKGVKGYYHNQEMTIESDLVIVADGAHSVLANQLGAFENDPERVMYTFRSMMTGVEGLEDDIIEQYYLPDTLPNEAHSPICVFWLCPQKSGVTLFGVTITEKALRETKFSIEELVEVWVTTTEFGKKRMQNAKVLDDYGYRGWRLPGCTKLHKSYYPGAIIIGDAISAAECAFEYGIPEAMFGGKIAAEVGAEIFAANGTFDEETLAEYRRRAEAQLNPTLGFNAIFRTELLDHKDRLDAFLKWAKEQPGYPNNDFGVNVAQFITKELGIPLQVGGEASMQ
>NC_016894.1|WP_014357743.1|3914135_3915842_-|FAD-dependent-oxidoreductase
MSEIRIVPNKNKEFVLKRAAVAHIDPKRCVNCGTCRELCPTDAIQENQRTICRICPGCTDKPGMSLDAMDAFTTKQSCTTACPLGISPQGYVNLVNCGKEKEAYELNWKKNPLPSVCAFICNHPCEEVCKRGVLVDQPIMIRGVKRFLSEHVDYVPEKYPRNYEERIAIIGAGPAGLAAGHFLSREGYNVTIFEGEAEAGGMLIKGIPEFRLDREALKRDISKLEEAGLEIKVNQRIGKFYLNKIRKEYDAVILAAGEPNGKLLKIPGHMNDAILTAMQFMQKANNDQTFVSCPGDFFRIKGGEGIIIGGGSVAMDVARAAVRLGAKNVTVVAVEEYDNLPAHAWEVKEAQEEGVQVLGGYCPTEYVNGGGGTFDHVHFVKVKEMIKDENNKLQFVFNEEEYIDIRGDFAVVATGQEADKSWPESDDKTFFYAGDISGESNCVIDAMASGRKTAYKVDAKLRGRTLRDMDLSHEIYAAPLNEKIYPANRRRVVTFEQPVLKPEDRVNNFEAVDLCYTEKQAKQEVSRCLSCGYEIVDVSKCIGCGICQKECPKGDVITMIAAEVRKEI
>NC_016894.1|WP_014357744.1|3916128_3916794_-|TetR/AcrR-family-transcriptional-regulator
MSQINDEKRSEILKCSYDLFSHNDYCSVFLKDIAAQVGISKSRLQNFFPKKREIIRNLLEEYIYQLFRYVEERLAVDVTVYYKLALFTAFFWKLIDRNKELHYFMMNVITNNELLDVLTDFVFCWHSEMKYEGVHNFEIANLRQSLIFSISGGSALYIKKDSLNIETLYITQNISDTFMRMMGCSDEQISEVLKNTSEWLPKMDVNSFLEYSRDNIAWMQP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016894_2	2.1\|3377751\|34\|NC_016894\|CRISPRCasFinder,CRT	3377751-3377784	34	NC_021561	Vibrio phage pYD38-B genomic sequence	25675-25708	8	0.765
NC_016894_2	2.6\|3378080\|34\|NC_016894\|CRISPRCasFinder,CRT	3378080-3378113	34	NC_011044	Mycobacterium phage Nigel, complete genome	65045-65078	8	0.765
NC_016894_2	2.52\|3378088\|34\|NC_016894\|PILER-CR	3378088-3378121	34	NC_011044	Mycobacterium phage Nigel, complete genome	65045-65078	8	0.765
NC_016894_2	2.33\|3379846\|35\|NC_016894\|CRISPRCasFinder,CRT	3379846-3379880	35	NC_013940	Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence	152505-152539	9	0.743
NC_016894_2	2.40\|3380306\|35\|NC_016894\|CRISPRCasFinder,CRT	3380306-3380340	35	NC_024989	Clostridium botulinum plasmid pMI06-01 DNA, complete genome, strain: Miyagi2006-01	15242-15276	9	0.743
NC_016894_2	2.40\|3380306\|35\|NC_016894\|CRISPRCasFinder,CRT	3380306-3380340	35	NC_025002	Clostridium botulinum plasmid pTO08 DNA, complete genome, strain: Tochigi2008	15242-15276	9	0.743
NC_016894_2	2.40\|3380306\|35\|NC_016894\|CRISPRCasFinder,CRT	3380306-3380340	35	NZ_LR134422	Legionella adelaidensis strain NCTC12735 genome assembly, plasmid: 13	163764-163798	9	0.743
NC_016894_2	2.40\|3380306\|35\|NC_016894\|CRISPRCasFinder,CRT	3380306-3380340	35	NC_011246	Borrelia recurrentis A1 plasmid pl124, complete sequence	19263-19297	9	0.743
NC_016894_2	2.40\|3380306\|35\|NC_016894\|CRISPRCasFinder,CRT	3380306-3380340	35	NC_011247	Borrelia duttonii Ly plasmid pl165, complete sequence	59081-59115	9	0.743
NC_016894_2	2.43\|3380504\|36\|NC_016894\|CRISPRCasFinder,CRT	3380504-3380539	36	NC_030925	Bacillus phage Shbh1, complete genome	24197-24232	9	0.75
NC_016894_2	2.79\|3379854\|35\|NC_016894\|PILER-CR	3379854-3379888	35	NC_013940	Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence	152505-152539	9	0.743
NC_016894_2	2.86\|3380314\|35\|NC_016894\|PILER-CR	3380314-3380348	35	NC_024989	Clostridium botulinum plasmid pMI06-01 DNA, complete genome, strain: Miyagi2006-01	15242-15276	9	0.743
NC_016894_2	2.86\|3380314\|35\|NC_016894\|PILER-CR	3380314-3380348	35	NC_025002	Clostridium botulinum plasmid pTO08 DNA, complete genome, strain: Tochigi2008	15242-15276	9	0.743
NC_016894_2	2.86\|3380314\|35\|NC_016894\|PILER-CR	3380314-3380348	35	NZ_LR134422	Legionella adelaidensis strain NCTC12735 genome assembly, plasmid: 13	163764-163798	9	0.743
NC_016894_2	2.86\|3380314\|35\|NC_016894\|PILER-CR	3380314-3380348	35	NC_011246	Borrelia recurrentis A1 plasmid pl124, complete sequence	19263-19297	9	0.743
NC_016894_2	2.86\|3380314\|35\|NC_016894\|PILER-CR	3380314-3380348	35	NC_011247	Borrelia duttonii Ly plasmid pl165, complete sequence	59081-59115	9	0.743
NC_016894_2	2.89\|3380512\|36\|NC_016894\|PILER-CR	3380512-3380547	36	NC_030925	Bacillus phage Shbh1, complete genome	24197-24232	9	0.75
NC_016894_2	2.40\|3380306\|35\|NC_016894\|CRISPRCasFinder,CRT	3380306-3380340	35	NZ_CP036355	Bacillus sp. SYJ plasmid unnamed1, complete sequence	205677-205711	10	0.714
NC_016894_2	2.40\|3380306\|35\|NC_016894\|CRISPRCasFinder,CRT	3380306-3380340	35	NC_014535	Gloeothece verrucosa PCC 7822 plasmid Cy782206, complete sequence	11707-11741	10	0.714
NC_016894_2	2.86\|3380314\|35\|NC_016894\|PILER-CR	3380314-3380348	35	NZ_CP036355	Bacillus sp. SYJ plasmid unnamed1, complete sequence	205677-205711	10	0.714
NC_016894_2	2.86\|3380314\|35\|NC_016894\|PILER-CR	3380314-3380348	35	NC_014535	Gloeothece verrucosa PCC 7822 plasmid Cy782206, complete sequence	11707-11741	10	0.714
NC_016894_2	2.35\|3379977\|35\|NC_016894\|CRISPRCasFinder,CRT	3379977-3380011	35	MN694725	Marine virus AFVG_250M823, complete genome	28083-28117	11	0.686
NC_016894_2	2.35\|3379977\|35\|NC_016894\|CRISPRCasFinder,CRT	3379977-3380011	35	MN694730	Marine virus AFVG_250M981, complete genome	28702-28736	11	0.686
NC_016894_2	2.40\|3380306\|35\|NC_016894\|CRISPRCasFinder,CRT	3380306-3380340	35	NC_010933	Bacillus cereus strain G9241 plasmid pBC210, complete sequence	66839-66873	11	0.686
NC_016894_2	2.40\|3380306\|35\|NC_016894\|CRISPRCasFinder,CRT	3380306-3380340	35	NZ_CP009940	Bacillus cereus strain 03BB87 plasmid pBCX01, complete sequence	120737-120771	11	0.686
NC_016894_2	2.40\|3380306\|35\|NC_016894\|CRISPRCasFinder,CRT	3380306-3380340	35	NZ_CP009591	Bacillus cereus G9241 plasmid pBC210, complete sequence	196249-196283	11	0.686
NC_016894_2	2.81\|3379985\|35\|NC_016894\|PILER-CR	3379985-3380019	35	MN694725	Marine virus AFVG_250M823, complete genome	28083-28117	11	0.686
NC_016894_2	2.81\|3379985\|35\|NC_016894\|PILER-CR	3379985-3380019	35	MN694730	Marine virus AFVG_250M981, complete genome	28702-28736	11	0.686
NC_016894_2	2.86\|3380314\|35\|NC_016894\|PILER-CR	3380314-3380348	35	NC_010933	Bacillus cereus strain G9241 plasmid pBC210, complete sequence	66839-66873	11	0.686
NC_016894_2	2.86\|3380314\|35\|NC_016894\|PILER-CR	3380314-3380348	35	NZ_CP009940	Bacillus cereus strain 03BB87 plasmid pBCX01, complete sequence	120737-120771	11	0.686
NC_016894_2	2.86\|3380314\|35\|NC_016894\|PILER-CR	3380314-3380348	35	NZ_CP009591	Bacillus cereus G9241 plasmid pBC210, complete sequence	196249-196283	11	0.686

1. spacer 2.1|3377751|34|NC_016894|CRISPRCasFinder,CRT matches to NC_021561 (Vibrio phage pYD38-B genomic sequence) position: , mismatch: 8, identity: 0.765

aataaattgagatggcaaaatgttatattcattc	CRISPR spacer
agcaactgtagctggcaaaatgttttattcattt	Protospacer
*..** *  ** ************ ********.

2. spacer 2.6|3378080|34|NC_016894|CRISPRCasFinder,CRT matches to NC_011044 (Mycobacterium phage Nigel, complete genome) position: , mismatch: 8, identity: 0.765

gaaaatgaagtcaatgccctagccccgg-cattgc	CRISPR spacer
gcccatgaaggcaatgccgtagccccggccaccg-	Protospacer
*   ****** ******* ********* **..*

3. spacer 2.52|3378088|34|NC_016894|PILER-CR matches to NC_011044 (Mycobacterium phage Nigel, complete genome) position: , mismatch: 8, identity: 0.765

gaaaatgaagtcaatgccctagccccgg-cattgc	CRISPR spacer
gcccatgaaggcaatgccgtagccccggccaccg-	Protospacer
*   ****** ******* ********* **..*

4. spacer 2.33|3379846|35|NC_016894|CRISPRCasFinder,CRT matches to NC_013940 (Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence) position: , mismatch: 9, identity: 0.743

aagaattgtttcttttgcttttctcatgtcttcaa	CRISPR spacer
ttcactggtttcttttgcttttctcatttcatctt	Protospacer
   * * ******************** ** **

5. spacer 2.40|3380306|35|NC_016894|CRISPRCasFinder,CRT matches to NC_024989 (Clostridium botulinum plasmid pMI06-01 DNA, complete genome, strain: Miyagi2006-01) position: , mismatch: 9, identity: 0.743

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
gatgatttaattaaagcttttaatgactacactaa	Protospacer
**.*************** *******.* .. *

6. spacer 2.40|3380306|35|NC_016894|CRISPRCasFinder,CRT matches to NC_025002 (Clostridium botulinum plasmid pTO08 DNA, complete genome, strain: Tochigi2008) position: , mismatch: 9, identity: 0.743

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
gatgatttaattaaagcttttaatgactacactaa	Protospacer
**.*************** *******.* .. *

7. spacer 2.40|3380306|35|NC_016894|CRISPRCasFinder,CRT matches to NZ_LR134422 (Legionella adelaidensis strain NCTC12735 genome assembly, plasmid: 13) position: , mismatch: 9, identity: 0.743

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
tttaatttaattaaagttattattgattttattta	Protospacer
  ..************.***** *******. **

8. spacer 2.40|3380306|35|NC_016894|CRISPRCasFinder,CRT matches to NC_011246 (Borrelia recurrentis A1 plasmid pl124, complete sequence) position: , mismatch: 9, identity: 0.743

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
gttagattttttaaagatattaattattttgattc	Protospacer
* ... **  ****** ******* **********

9. spacer 2.40|3380306|35|NC_016894|CRISPRCasFinder,CRT matches to NC_011247 (Borrelia duttonii Ly plasmid pl165, complete sequence) position: , mismatch: 9, identity: 0.743

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
gttagattttttaaagatattaattattttgattc	Protospacer
* ... **  ****** ******* **********

10. spacer 2.43|3380504|36|NC_016894|CRISPRCasFinder,CRT matches to NC_030925 (Bacillus phage Shbh1, complete genome) position: , mismatch: 9, identity: 0.75

ctttttacatcttttaagttcatttttattcctccc	CRISPR spacer
gcaagtaactcttttattttcatttttattcctccc	Protospacer
 .   **  *******  ******************

11. spacer 2.79|3379854|35|NC_016894|PILER-CR matches to NC_013940 (Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence) position: , mismatch: 9, identity: 0.743

aagaattgtttcttttgcttttctcatgtcttcaa	CRISPR spacer
ttcactggtttcttttgcttttctcatttcatctt	Protospacer
   * * ******************** ** **

12. spacer 2.86|3380314|35|NC_016894|PILER-CR matches to NC_024989 (Clostridium botulinum plasmid pMI06-01 DNA, complete genome, strain: Miyagi2006-01) position: , mismatch: 9, identity: 0.743

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
gatgatttaattaaagcttttaatgactacactaa	Protospacer
**.*************** *******.* .. *

13. spacer 2.86|3380314|35|NC_016894|PILER-CR matches to NC_025002 (Clostridium botulinum plasmid pTO08 DNA, complete genome, strain: Tochigi2008) position: , mismatch: 9, identity: 0.743

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
gatgatttaattaaagcttttaatgactacactaa	Protospacer
**.*************** *******.* .. *

14. spacer 2.86|3380314|35|NC_016894|PILER-CR matches to NZ_LR134422 (Legionella adelaidensis strain NCTC12735 genome assembly, plasmid: 13) position: , mismatch: 9, identity: 0.743

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
tttaatttaattaaagttattattgattttattta	Protospacer
  ..************.***** *******. **

15. spacer 2.86|3380314|35|NC_016894|PILER-CR matches to NC_011246 (Borrelia recurrentis A1 plasmid pl124, complete sequence) position: , mismatch: 9, identity: 0.743

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
gttagattttttaaagatattaattattttgattc	Protospacer
* ... **  ****** ******* **********

16. spacer 2.86|3380314|35|NC_016894|PILER-CR matches to NC_011247 (Borrelia duttonii Ly plasmid pl165, complete sequence) position: , mismatch: 9, identity: 0.743

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
gttagattttttaaagatattaattattttgattc	Protospacer
* ... **  ****** ******* **********

17. spacer 2.89|3380512|36|NC_016894|PILER-CR matches to NC_030925 (Bacillus phage Shbh1, complete genome) position: , mismatch: 9, identity: 0.75

ctttttacatcttttaagttcatttttattcctccc	CRISPR spacer
gcaagtaactcttttattttcatttttattcctccc	Protospacer
 .   **  *******  ******************

18. spacer 2.40|3380306|35|NC_016894|CRISPRCasFinder,CRT matches to NZ_CP036355 (Bacillus sp. SYJ plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
taaactccaattgaacctattaatgattttgatag	Protospacer
 * . *..****.** *****************

19. spacer 2.40|3380306|35|NC_016894|CRISPRCasFinder,CRT matches to NC_014535 (Gloeothece verrucosa PCC 7822 plasmid Cy782206, complete sequence) position: , mismatch: 10, identity: 0.714

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
tgggttttaattaatgctattaatgttttttgata	Protospacer
 . * ********* ********** **** . *

20. spacer 2.86|3380314|35|NC_016894|PILER-CR matches to NZ_CP036355 (Bacillus sp. SYJ plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
taaactccaattgaacctattaatgattttgatag	Protospacer
 * . *..****.** *****************

21. spacer 2.86|3380314|35|NC_016894|PILER-CR matches to NC_014535 (Gloeothece verrucosa PCC 7822 plasmid Cy782206, complete sequence) position: , mismatch: 10, identity: 0.714

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
tgggttttaattaatgctattaatgttttttgata	Protospacer
 . * ********* ********** **** . *

22. spacer 2.35|3379977|35|NC_016894|CRISPRCasFinder,CRT matches to MN694725 (Marine virus AFVG_250M823, complete genome) position: , mismatch: 11, identity: 0.686

tcgccatcgtcattcccagtaacgacaatatccga	CRISPR spacer
ccaaagcatccattcccagtaacgacaaaatcgga	Protospacer
.*.  ..  .****************** *** **

23. spacer 2.35|3379977|35|NC_016894|CRISPRCasFinder,CRT matches to MN694730 (Marine virus AFVG_250M981, complete genome) position: , mismatch: 11, identity: 0.686

tcgccatcgtcattcccagtaacgacaatatccga	CRISPR spacer
ccaaagcatccattcccagtaacgacaaaatcgga	Protospacer
.*.  ..  .****************** *** **

24. spacer 2.40|3380306|35|NC_016894|CRISPRCasFinder,CRT matches to NC_010933 (Bacillus cereus strain G9241 plasmid pBC210, complete sequence) position: , mismatch: 11, identity: 0.686

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
taaacgccaattgaacctattaatgattttgatag	Protospacer
 * .  ..****.** *****************

25. spacer 2.40|3380306|35|NC_016894|CRISPRCasFinder,CRT matches to NZ_CP009940 (Bacillus cereus strain 03BB87 plasmid pBCX01, complete sequence) position: , mismatch: 11, identity: 0.686

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
taaacgccaattgaacctattaatgattttgatag	Protospacer
 * .  ..****.** *****************

26. spacer 2.40|3380306|35|NC_016894|CRISPRCasFinder,CRT matches to NZ_CP009591 (Bacillus cereus G9241 plasmid pBC210, complete sequence) position: , mismatch: 11, identity: 0.686

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
taaacgccaattgaacctattaatgattttgatag	Protospacer
 * .  ..****.** *****************

27. spacer 2.81|3379985|35|NC_016894|PILER-CR matches to MN694725 (Marine virus AFVG_250M823, complete genome) position: , mismatch: 11, identity: 0.686

tcgccatcgtcattcccagtaacgacaatatccga	CRISPR spacer
ccaaagcatccattcccagtaacgacaaaatcgga	Protospacer
.*.  ..  .****************** *** **

28. spacer 2.81|3379985|35|NC_016894|PILER-CR matches to MN694730 (Marine virus AFVG_250M981, complete genome) position: , mismatch: 11, identity: 0.686

tcgccatcgtcattcccagtaacgacaatatccga	CRISPR spacer
ccaaagcatccattcccagtaacgacaaaatcgga	Protospacer
.*.  ..  .****************** *** **

29. spacer 2.86|3380314|35|NC_016894|PILER-CR matches to NC_010933 (Bacillus cereus strain G9241 plasmid pBC210, complete sequence) position: , mismatch: 11, identity: 0.686

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
taaacgccaattgaacctattaatgattttgatag	Protospacer
 * .  ..****.** *****************

30. spacer 2.86|3380314|35|NC_016894|PILER-CR matches to NZ_CP009940 (Bacillus cereus strain 03BB87 plasmid pBCX01, complete sequence) position: , mismatch: 11, identity: 0.686

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
taaacgccaattgaacctattaatgattttgatag	Protospacer
 * .  ..****.** *****************

31. spacer 2.86|3380314|35|NC_016894|PILER-CR matches to NZ_CP009591 (Bacillus cereus G9241 plasmid pBC210, complete sequence) position: , mismatch: 11, identity: 0.686

gacgatttaattaaagctattaatgattttgattc	CRISPR spacer
taaacgccaattgaacctattaatgattttgatag	Protospacer
 * .  ..****.** *****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

144479 : 152177

Bacillus_phage(50.0%)

transposase,integrase

attL 148003:148016|attR 155627:155640

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014354544.1\|144479_145988_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	2.7e-55	34.8
WP_083837915.1\|146603_147203_-\|integrase	site-specific integrase	A0A0S2SXP1	Bacillus_phage	2.5e-20	33.0
WP_014354546.1\|147569_148106_+	hypothetical protein	NA	NA	NA	NA
148003:148016	attL	NA	NA	NA	NA
WP_014354547.1\|148252_149512_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	M4T586	Rhodobacter_phage	1.3e-15	27.6
WP_014354548.1\|149504_150305_+	AAA family ATPase	NA	NA	NA	NA
WP_014354549.1\|150381_150804_-\|integrase	phage integrase	A0A0U3U8Y8	Bacillus_phage	2.4e-06	33.3
WP_041669838.1\|150924_151104_-	helix-turn-helix domain-containing protein	A0A1B0T6C2	Bacillus_phage	9.6e-05	41.7
WP_014354551.1\|151418_152177_-	phage antirepressor KilAC domain-containing protein	A0A0H4TEY4	Erysipelothrix_phage	9.6e-38	39.3
155627:155640	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1920565 : 1933851

Synechococcus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014356016.1\|1920565_1922707_-	diguanylate cyclase	A0A220YL79	Alteromonas_virus	4.9e-10	31.9
WP_014356017.1\|1922788_1923487_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_014356018.1\|1923769_1927495_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	3.0e-31	25.3
WP_014356019.1\|1927574_1928069_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	9.1e-29	45.8
WP_014356020.1\|1928104_1928812_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	6.9e-46	44.2
WP_014356021.1\|1928892_1930281_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	6.2e-59	34.3
WP_014356022.1\|1930362_1931418_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SCX2	Cyanophage	7.3e-68	44.1
WP_014356023.1\|1931399_1932056_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.6e-25	38.8
WP_014356024.1\|1932321_1933851_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	6.6e-70	47.5

DBSCAN-SWA_3

3570878 : 3589662

Clostridium_phage(64.29%)

capsid,integrase,tail,protease,terminase,holin

attL 3584210:3584223|attR 3590252:3590265

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014357413.1\|3570878_3571313_-\|holin	phage holin family protein	M9Q253	Clostridium_phage	1.5e-22	45.8
WP_014357414.1\|3571412_3571565_-	hypothetical protein	NA	NA	NA	NA
WP_041669151.1\|3571581_3571914_-	hypothetical protein	NA	NA	NA	NA
WP_014357416.1\|3571917_3573210_-	hypothetical protein	NA	NA	NA	NA
WP_014357417.1\|3573211_3574237_-	hypothetical protein	E2ELJ8	Clostridium_phage	6.4e-61	50.6
WP_014357418.1\|3574250_3575339_-	siphovirus ReqiPepy6 Gp37-like family protein	A0A0K2CZQ1	Paenibacillus_phage	1.7e-59	34.8
WP_014357419.1\|3575340_3576204_-\|tail	phage tail family protein	E2ELJ6	Clostridium_phage	5.1e-59	44.4
WP_014357420.1\|3576213_3579543_-\|tail	phage tail tape measure protein	G4KNQ9	Staphylococcus_phage	1.3e-107	48.8
WP_014357421.1\|3579532_3579802_-	hypothetical protein	NA	NA	NA	NA
WP_014357422.1\|3579864_3580269_-	hypothetical protein	NA	NA	NA	NA
WP_014357423.1\|3580273_3581116_-	chitobiase/beta-hexosaminidase C-terminal domain-containing protein	A0A0U4IS63	Bacillus_phage	3.7e-46	47.6
WP_041669153.1\|3581230_3581479_-	hypothetical protein	NA	NA	NA	NA
WP_041669156.1\|3581468_3581927_-	hypothetical protein	NA	NA	NA	NA
WP_014357813.1\|3581889_3582225_-	hypothetical protein	Q0H236	Geobacillus_phage	8.4e-10	37.9
WP_014357427.1\|3582225_3582528_-	DNA-packaging protein	A0A1L2BY95	Clostridium_phage	8.3e-17	51.6
WP_014357428.1\|3582569_3583805_-\|capsid	phage major capsid protein	A0A290FZS5	Caldibacillus_phage	6.7e-105	50.6
WP_014357429.1\|3583797_3584571_-\|protease	Clp protease ClpP	A0A1L2BY92	Clostridium_phage	3.1e-47	44.2
3584210:3584223	attL	NA	NA	NA	NA
WP_014357431.1\|3585758_3587414_-\|terminase	terminase large subunit	A0A0A8WI49	Clostridium_phage	7.8e-226	68.7
WP_014357815.1\|3587410_3587794_-	hypothetical protein	A0A1L2BY96	Clostridium_phage	4.7e-25	51.6
WP_014357433.1\|3587896_3588628_-	HNH endonuclease	A0A0A8WJ48	Clostridium_phage	1.6e-18	44.1
WP_014357817.1\|3588629_3588887_-	hypothetical protein	NA	NA	NA	NA
WP_052307152.1\|3589098_3589662_-\|integrase	tyrosine-type recombinase/integrase	A0A0A8WF93	Clostridium_phage	9.0e-65	67.2
3590252:3590265	attR	NA	NA	NA	NA

DBSCAN-SWA_4

3880300 : 3943307

Bacillus_phage(30.0%)

transposase,integrase,protease,bacteriocin

attL 3941031:3941060|attR 3947082:3947111

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014357715.1\|3880300_3880726_-\|transposase	transposase	A0A1X9I5T2	Streptococcus_phage	9.9e-24	50.0
WP_145972751.1\|3880741_3880975_-	hypothetical protein	A0A1X9I5T2	Streptococcus_phage	3.4e-18	61.5
WP_169314715.1\|3882236_3882389_-	hypothetical protein	NA	NA	NA	NA
WP_014357717.1\|3883126_3883984_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_193353297.1\|3884139_3884775_-	N-acetyltransferase	NA	NA	NA	NA
WP_145972752.1\|3885499_3885733_-	hypothetical protein	NA	NA	NA	NA
WP_145972753.1\|3885810_3886068_+	hypothetical protein	NA	NA	NA	NA
WP_014357721.1\|3886087_3887551_-	YdiU family protein	A0A075BSJ0	Microcystis_phage	3.1e-48	31.3
WP_014357722.1\|3887620_3888112_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014357723.1\|3888419_3889388_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_041669496.1\|3889472_3890066_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014357725.1\|3890224_3892222_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_041669499.1\|3892526_3893228_+	lantibiotic protection ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.7e-57	50.2
WP_014357727.1\|3893227_3893989_+	lantibiotic immunity ABC transporter MutE/EpiE family permease subunit	NA	NA	NA	NA
WP_014357728.1\|3893985_3894714_+	lantibiotic immunity ABC transporter MutG family permease subunit	NA	NA	NA	NA
WP_014357729.1\|3894729_3895404_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.7e-30	35.0
WP_014357730.1\|3895379_3896711_+	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_145972736.1\|3897012_3898132_+\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	3.0e-88	58.0
WP_014357731.1\|3898129_3898597_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_169314716.1\|3899849_3905132_-	leucine-rich repeat protein	NA	NA	NA	NA
WP_014357733.1\|3905420_3905669_-	DUF2442 domain-containing protein	NA	NA	NA	NA
WP_014357734.1\|3906051_3908538_+	LuxR family transcriptional regulator	NA	NA	NA	NA
WP_169314717.1\|3909259_3909646_-	hypothetical protein	NA	NA	NA	NA
WP_169314718.1\|3909680_3909833_-	hypothetical protein	NA	NA	NA	NA
WP_014357737.1\|3909921_3911073_-	DUF924 family protein	NA	NA	NA	NA
WP_169314719.1\|3911635_3911746_-	hypothetical protein	NA	NA	NA	NA
WP_014357740.1\|3911883_3912087_-	hypothetical protein	NA	NA	NA	NA
WP_014357742.1\|3912901_3914134_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_014357743.1\|3914135_3915842_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_014357744.1\|3916128_3916794_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_145972754.1\|3917218_3917404_+	hypothetical protein	NA	NA	NA	NA
WP_014357746.1\|3917446_3917704_-	hypothetical protein	NA	NA	NA	NA
WP_041669503.1\|3917874_3918249_-	PH domain-containing protein	A6N235	Microbacterium_phage	1.0e-40	69.2
WP_041669509.1\|3919016_3919394_-	RidA family protein	NA	NA	NA	NA
WP_041669511.1\|3919421_3920609_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_014357751.1\|3920617_3921913_-	amino acid permease	NA	NA	NA	NA
WP_014357752.1\|3922066_3922525_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_014357753.1\|3922978_3923278_-	STAS domain-containing protein	NA	NA	NA	NA
WP_014357754.1\|3923513_3923657_-	hypothetical protein	NA	NA	NA	NA
WP_014357755.1\|3923749_3924016_-	hypothetical protein	NA	NA	NA	NA
WP_041669514.1\|3924111_3924525_-	hypothetical protein	NA	NA	NA	NA
WP_014357756.1\|3924612_3926823_-\|bacteriocin	NHLP bacteriocin export ABC transporter permease/ATPase subunit	W8CYL7	Bacillus_phage	6.3e-21	24.9
WP_052307121.1\|3926839_3929020_-\|bacteriocin	NHLP family bacteriocin export ABC transporter peptidase/permease/ATPase subunit	W8CYL7	Bacillus_phage	4.2e-25	23.2
WP_041669518.1\|3929030_3929513_-	hypothetical protein	NA	NA	NA	NA
WP_041669524.1\|3929737_3930775_-	dihydrodipicolinate reductase	NA	NA	NA	NA
WP_041671669.1\|3930887_3931721_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_014357761.1\|3931980_3932460_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_041669529.1\|3932608_3933013_-	GFA family protein	NA	NA	NA	NA
WP_014357763.1\|3933163_3934051_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_014357764.1\|3934188_3935043_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_041669534.1\|3935160_3936198_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_014357766.1\|3936434_3936581_-	DUF1835 domain-containing protein	NA	NA	NA	NA
WP_145972755.1\|3936713_3937040_-	ABC transporter permease	NA	NA	NA	NA
WP_041669537.1\|3937161_3937971_+	EFR1 family ferrodoxin	NA	NA	NA	NA
WP_014357768.1\|3938292_3938850_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014357769.1\|3939017_3940991_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
3941031:3941060	attL	NA	NA	NA	NA
WP_014354546.1\|3941364_3941901_+	hypothetical protein	NA	NA	NA	NA
WP_014354547.1\|3942047_3943307_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	M4T586	Rhodobacter_phage	1.3e-15	27.6
3947082:3947111	attR	NA	NA	NA	NA

DBSCAN-SWA_5

3956431 : 4006028

Clostridium_phage(41.94%)

capsid,integrase,tail,protease,portal,terminase,transposase,holin

attL 3961017:3961032|attR 4005738:4005753

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014357783.1\|3956431_3956944_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	3.8e-54	59.4
WP_014357784.1\|3957844_3960106_+	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	2.5e-137	34.7
WP_014357785.1\|3960118_3960541_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_041669558.1\|3960918_3961776_+\|transposase	transposase	NA	NA	NA	NA
3961017:3961032	attL	NA	NA	NA	NA
WP_014354548.1\|3962029_3962830_-	AAA family ATPase	NA	NA	NA	NA
WP_014354547.1\|3962822_3964082_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	M4T586	Rhodobacter_phage	1.3e-15	27.6
WP_014354546.1\|3964228_3964765_-	hypothetical protein	NA	NA	NA	NA
WP_014357788.1\|3964943_3965609_+\|transposase	transposase	NA	NA	NA	NA
WP_014357790.1\|3965837_3966272_-	HD domain-containing protein	A0A0F7L746	uncultured_marine_virus	1.4e-28	56.2
WP_014357791.1\|3966551_3966737_-	hypothetical protein	NA	NA	NA	NA
WP_014357792.1\|3966908_3967769_-	hypothetical protein	NA	NA	NA	NA
WP_145972736.1\|3968744_3969865_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	3.0e-88	58.0
WP_169314721.1\|3970307_3970664_-\|transposase	transposase	NA	NA	NA	NA
WP_014357796.1\|3970836_3971217_-	hypothetical protein	NA	NA	NA	NA
WP_014357797.1\|3971335_3972058_-	hypothetical protein	NA	NA	NA	NA
WP_145972736.1\|3974203_3975323_+\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	3.0e-88	58.0
WP_014357798.1\|3975403_3976159_-	DNA adenine methylase	A0A2H4IYF4	uncultured_Caudovirales_phage	7.8e-80	55.5
WP_041669567.1\|3976275_3977268_-	N-acetylmuramoyl-L-alanine amidase	A0A0N9SGH1	Paenibacillus_phage	6.3e-05	29.5
WP_014357800.1\|3977269_3977701_-\|holin	phage holin family protein	M9Q253	Clostridium_phage	1.6e-21	44.2
WP_014357801.1\|3977738_3977891_-	hypothetical protein	NA	NA	NA	NA
WP_145972826.1\|3977909_3978167_-	hypothetical protein	NA	NA	NA	NA
WP_014357803.1\|3978243_3979518_-	hypothetical protein	NA	NA	NA	NA
WP_014357804.1\|3979519_3980545_-	hypothetical protein	E2ELJ8	Clostridium_phage	3.4e-62	51.0
WP_014357805.1\|3980558_3981647_-	siphovirus ReqiPepy6 Gp37-like family protein	A0A0K2CZQ1	Paenibacillus_phage	1.3e-59	35.3
WP_014357806.1\|3981648_3982512_-\|tail	phage tail family protein	E2ELJ6	Clostridium_phage	1.5e-58	44.1
WP_014357807.1\|3982521_3985833_-\|tail	phage tail tape measure protein	G4KNQ9	Staphylococcus_phage	1.3e-107	48.8
WP_014357808.1\|3985822_3986092_-	hypothetical protein	NA	NA	NA	NA
WP_014357809.1\|3986154_3986559_-	hypothetical protein	NA	NA	NA	NA
WP_014357810.1\|3986563_3987406_-	chitobiase/beta-hexosaminidase C-terminal domain-containing protein	A0A0U4IS63	Bacillus_phage	3.7e-46	47.6
WP_041669587.1\|3987409_3987769_-	hypothetical protein	NA	NA	NA	NA
WP_041669589.1\|3987758_3988217_-	hypothetical protein	NA	NA	NA	NA
WP_014357813.1\|3988179_3988515_-	hypothetical protein	Q0H236	Geobacillus_phage	8.4e-10	37.9
WP_014357427.1\|3988515_3988818_-	DNA-packaging protein	A0A1L2BY95	Clostridium_phage	8.3e-17	51.6
WP_014357428.1\|3988859_3990095_-\|capsid	phage major capsid protein	A0A290FZS5	Caldibacillus_phage	6.7e-105	50.6
WP_014357429.1\|3990087_3990861_-\|protease	Clp protease ClpP	A0A1L2BY92	Clostridium_phage	3.1e-47	44.2
WP_014357814.1\|3990863_3991988_-\|portal	phage portal protein	A0A1L2BY94	Clostridium_phage	1.4e-138	63.9
WP_014357431.1\|3992049_3993705_-\|terminase	terminase large subunit	A0A0A8WI49	Clostridium_phage	7.8e-226	68.7
WP_014357815.1\|3993701_3994085_-	hypothetical protein	A0A1L2BY96	Clostridium_phage	4.7e-25	51.6
WP_014357433.1\|3994187_3994919_-	HNH endonuclease	A0A0A8WJ48	Clostridium_phage	1.6e-18	44.1
WP_014357817.1\|3994920_3995178_-	hypothetical protein	NA	NA	NA	NA
WP_052307153.1\|3995389_3995953_-\|integrase	tyrosine-type recombinase/integrase	A0A0A8WF93	Clostridium_phage	1.2e-64	67.2
WP_169314722.1\|3996005_3996146_-	hypothetical protein	NA	NA	NA	NA
WP_041669168.1\|3996265_3996688_-	hypothetical protein	NA	NA	NA	NA
WP_145972828.1\|3996779_3997595_-	DNA adenine methylase	Q24LC8	Clostridium_phage	4.5e-57	41.5
WP_169314723.1\|3997611_3997758_-	hypothetical protein	NA	NA	NA	NA
WP_014357820.1\|3997767_3998622_-	hypothetical protein	NA	NA	NA	NA
WP_041669176.1\|3998618_3998888_-	hypothetical protein	NA	NA	NA	NA
WP_041669591.1\|3998877_3999099_-	hypothetical protein	NA	NA	NA	NA
WP_145972756.1\|3999100_3999892_-	DNA (cytosine-5-)-methyltransferase	A8YQM6	Lactobacillus_phage	1.1e-63	49.0
WP_169314724.1\|3999973_4000144_-	hypothetical protein	A0A1J0MGB9	Staphylococcus_phage	1.8e-05	43.8
WP_041669593.1\|4000136_4000343_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_169314725.1\|4000339_4000516_-	hypothetical protein	NA	NA	NA	NA
WP_014357441.1\|4000516_4000702_-	hypothetical protein	NA	NA	NA	NA
WP_169314726.1\|4000698_4001103_-	hypothetical protein	NA	NA	NA	NA
WP_052307123.1\|4001041_4001347_-	hypothetical protein	NA	NA	NA	NA
WP_014357822.1\|4001339_4002158_-	hypothetical protein	I6XGC7	Burkholderia_virus	1.0e-29	55.7
WP_014357823.1\|4002154_4002385_-	hypothetical protein	NA	NA	NA	NA
WP_014357824.1\|4002442_4003147_-	hypothetical protein	A0A0A7RUC6	Clostridium_phage	1.8e-46	44.4
WP_014357825.1\|4003143_4003473_-	hypothetical protein	A0A1L2JY32	Aeribacillus_phage	1.7e-10	36.5
WP_041669602.1\|4003459_4003648_-	hypothetical protein	NA	NA	NA	NA
WP_014357826.1\|4003707_4004196_-	helix-turn-helix transcriptional regulator	A0A1L2BY71	Clostridium_phage	2.6e-20	39.1
WP_145972829.1\|4004255_4004615_-	hypothetical protein	NA	NA	NA	NA
WP_041669611.1\|4004638_4004866_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_169314727.1\|4004888_4005041_-	hypothetical protein	NA	NA	NA	NA
WP_169314728.1\|4005050_4005206_-	hypothetical protein	NA	NA	NA	NA
WP_041669615.1\|4005232_4005466_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014357828.1\|4005632_4006028_+	helix-turn-helix transcriptional regulator	A0A1L2JY18	Aeribacillus_phage	8.9e-11	33.3
4005738:4005753	attR	NA	NA	NA	NA

DBSCAN-SWA_6

4017850 : 4027704

Streptococcus_phage(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014357839.1\|4017850_4018837_-	DNA polymerase III subunit delta'	A0A1L2BWV7	Bacteriophage	1.9e-17	33.7
WP_014357840.1\|4018860_4019172_-	DUF2007 domain-containing protein	NA	NA	NA	NA
WP_083837914.1\|4019164_4021297_-	aminotransferase class V-fold PLP-dependent enzyme	G3MB74	Bacillus_virus	3.7e-26	33.8
WP_014357842.1\|4021422_4021749_+	thioredoxin	A0A1X9I9P5	Staphylococcus_phage	1.2e-16	47.4
WP_014357843.1\|4021808_4023755_-\|tRNA	methionine--tRNA ligase	A0A1V0SEZ7	Hokovirus	5.8e-103	35.9
WP_014357844.1\|4024106_4024949_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	7.9e-49	39.1
WP_014357845.1\|4024949_4026338_-	FAD-binding protein	NA	NA	NA	NA
WP_014357846.1\|4026348_4027704_-	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	1.1e-103	45.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_016894

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection