CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_017586	Streptomyces cattleya NRRL 8057 = DSM 46488, complete sequence	8 crisprs	WYL,csa3,DEDDh,cas3,DinG,cas4	0	4	3	0
NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	2 crisprs	WYL,csa3	0	7	0	0

1. NC_017586

CRISPR-Cas detection and classification

Crispr_ID: NC_017586_1

• CRISPR_ID: NC_017586_1
• CRISPR_location: 643707-643918
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_017586_1

Consensus_repeat	Method
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	PILER-CR
GTCGTCCCCGCCAGCGCGGGGGTAGCCC	CRISPRCasFinder
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	CRT

spacers of NC_017586_1

>1.1|643736|32|NC_017586|PILER-CR,CRT
TGGGGTATGTGTGTCCCACTCCGCCAGGTCGA
>1.2|643797|32|NC_017586|PILER-CR,CRT
AACCGAGGGCGGCGCATGCCACCCGTGCGATC
>1.3|643735|33|NC_017586|CRISPRCasFinder
GTGGGGTATGTGTGTCCCACTCCGCCAGGTCGA
>1.4|643796|33|NC_017586|CRISPRCasFinder
GAACCGAGGGCGGCGCATGCCACCCGTGCGATC
>1.5|643857|33|NC_017586|CRISPRCasFinder
CATCGCCACCCGGCCCCGCACGCACGAGCGCGT
>1.6|643858|32|NC_017586|CRT
ATCGCCACCCGGCCCCGCACGCACGAGCGCGT

CRISPR arrays and Neighbor proteins around NC_017586_1

CRISPR arrays

The CRISPR arrays of NC_017586_1

>merge|NC_017586|1|643707-643918|PILER-CR,CRISPRCasFinder,CRT
GTCGTCCCCGCCAGCGCGGGGGTAGCCCGTGGGGTATGTGTGTCCCACTCCGCCAGGTCGAGTCGTCCCCGCCAGCGCGGGGGTAGCCCGAACCGAGGGCGGCGCATGCCACCCGTGCGATCGTCGTCCCCGCCAGCGCGGGGGTAGCCCCATCGCCACCCGGCCCCGCACGCACGAGCGCGTGTCGTCCCCGCGAGCGCGGGGTTAGGTCG

>NC_017586|1|1|643707-643857|PILER-CR
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	TGGGGTATGTGTGTCCCACTCCGCCAGGTCGA
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	AACCGAGGGCGGCGCATGCCACCCGTGCGATC
GTCGTCCCCGCCAGCGCGGGGGTAGCCCC

>NC_017586|1|1|643707-643917|CRISPRCasFinder
GTCGTCCCCGCCAGCGCGGGGGTAGCCC	GTGGGGTATGTGTGTCCCACTCCGCCAGGTCGA
GTCGTCCCCGCCAGCGCGGGGGTAGCCC	GAACCGAGGGCGGCGCATGCCACCCGTGCGATC
GTCGTCCCCGCCAGCGCGGGGGTAGCCC	CATCGCCACCCGGCCCCGCACGCACGAGCGCGT
GTCGTCCCCGCGAGCGCGGGGTTAGGTC

>NC_017586|1|1|643707-643918|CRT
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	TGGGGTATGTGTGTCCCACTCCGCCAGGTCGA
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	AACCGAGGGCGGCGCATGCCACCCGTGCGATC
GTCGTCCCCGCCAGCGCGGGGGTAGCCCC	ATCGCCACCCGGCCCCGCACGCACGAGCGCGT
GTCGTCCCCGCGAGCGCGGGGTTAGGTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017586.1|WP_014141302.1|631206_632109_+|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	unknown
NC_017586.1|WP_014141318.1|646449_646755_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014141305.1|633924_635070_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|275041
NC_017586.1|WP_014141307.1|636577_636775_+|FxLD-family-lantipeptide	unknown	unknown	gnl|CDD|275157
NC_017586.1|WP_014141301.1|630432_631071_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014141308.1|636852_639915_+|lantibiotic-dehydratase	unknown	unknown	gnl|CDD|377403
NC_017586.1|WP_014141304.1|632953_633802_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014141325.1|650296_650839_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014141317.1|645595_646327_-|hypothetical-protein	unknown	unknown	gnl|CDD|223704
NC_017586.1|WP_014141322.1|648962_649304_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014141319.1|646877_648275_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014141323.1|649377_649791_-|hypothetical-protein	unknown	unknown	gnl|CDD|235450
NC_017586.1|WP_014141309.1|639911_641138_+|lanthionine-synthetase-C-family-protein	unknown	unknown	gnl|CDD|271201
NC_017586.1|WP_014141312.1|643235_643451_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014141306.1|635285_636563_+|methyltransferase,-FxLD-system	unknown	unknown	gnl|CDD|275158
NC_017586.1|WP_014141324.1|649872_650286_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014627360.1|645408_645615_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014141320.1|648286_648730_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014141314.1|644070_644388_+|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|367559
NC_017586.1|WP_014141303.1|632264_632957_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017586.1|WP_014141323.1|649377_649791_-|hypothetical-protein	gnl|CDD|235450	PRK05416, PRK05416, RNase adapter RapZ.	1.47122e-16
NC_017586.1|WP_014141309.1|639911_641138_+|lanthionine-synthetase-C-family-protein	gnl|CDD|271201	cd04793, LanC, Cyclases involved in the biosynthesis of lantibiotics. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links called lanthionines (Lans) or methyllanthionines (MeLans) in addition to 2,3-didehydroalanine (Dha) and (Z)-2,3-didehydrobutyrine (Dhb). These unusual amino acids are introduced by the dehydration of serine and threonine residues, followed by thioether formation via addition of cysteine thiols, catalysed by LanB and LanC or LanM. LanC, the cyclase component, is a zinc metalloprotein, whose bound metal has been proposed to activate the thiol substrate for nucleophilic addition. Also contains SpaC (the cyclase involved in the biosynthesis of subtilin), NisC, and homologs.	5.35006e-111
NC_017586.1|WP_014141306.1|635285_636563_+|methyltransferase,-FxLD-system	gnl|CDD|275158	TIGR04364, methyltran_FxLD, methyltransferase, FxLD system. Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.	0
NC_017586.1|WP_014141307.1|636577_636775_+|FxLD-family-lantipeptide	gnl|CDD|275157	TIGR04363, hypothetical_protein, FxLD family lantipeptide. Members of this protein family occur with a cassette of lanthionine-type peptide modification enzymes. Members are small (about 60 amino acids long), rich in Cys, and variable in copy number per genome (from one to three). These features suggest that members of this family are modified to become lantipeptides, although not necessarily a lantibiotic. There is no GlyGly cleavage motif to separate a leader peptide from core region.The considerable abundance in Streptomyces and relatively strong consideration hints at a non-antibiotic function. The motif FxLD in the N-terminal region is nearly invariant.	7.31458e-07
NC_017586.1|WP_014141308.1|636852_639915_+|lantibiotic-dehydratase	gnl|CDD|377403	pfam04738, Lant_dehydr_N, Lantibiotic dehydratase, C-terminus. Lantibiotics are ribosomally synthesized antimicrobial agents derived from ribosomally synthesized peptides. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues. This family constitutes the N-terminus of the enzyme proposed to catalyze the dehydration step, via glutamylation of the substrate during lantibiotic biosynthesis. The enzyme dehydrates Ser/Thr residues in the precursor by glutamylation.	0
NC_017586.1|WP_014141317.1|645595_646327_-|hypothetical-protein	gnl|CDD|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	6.45522e-16
NC_017586.1|WP_014141314.1|644070_644388_+|PadR-family-transcriptional-regulator	gnl|CDD|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	4.59965e-09
NC_017586.1|WP_014141305.1|633924_635070_+|methyltransferase-domain-containing-protein	gnl|CDD|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	3.88823e-77

Protein sequences

>NC_017586.1|WP_014141312.1|643235_643451_-|hypothetical-protein
MKHDEYHWVVTLMWVQGDQTLLRGRQGIITVQRPGTTRQDLFHEVLEYTRTTVGAPESAGVIFWSLKRNRL
>NC_017586.1|WP_014141309.1|639911_641138_+|lanthionine-synthetase-C-family-protein
MTTPVSLSTAEHLARYLALPEPASLDKPGEAQSLARGPAGIALLHIERAHTGDGTWQQAHAWITRAVAGPISAAENTGLYLGAPAVAYMLHTAAIGSTTRYRGALQDVDKHVTAAAHQHTDAAMARLGGGQLPTFREYDIFSGLTGTGALILHRAPGSSALGRILDYLVALIRPVTIDGQELPGWWACHDPRLRTSARYPDGHGNFGAAHGITGPLLLLSQAARRGITVDGHHEAIGTILAWLDTWRQDGDAGPWWPEHITLGELRTGRARQAGPARPSWCYGTPGIARAGQLAAFATGDRRRQQLYEDALHQCLADPVQMGRLTDAGLCHGWAGVYQTVWRAARDATTPALATHLPRLAEALVEHAGSGGEDEPGFLNGAAGTALALTTAARDAAPISGWDACLLIN
>NC_017586.1|WP_014141308.1|636852_639915_+|lantibiotic-dehydratase
MTSDVSYQWLPCALLRATTAPGTLDLPRDLDLASDTTAAREWLATVWQRQEVRDTLAVASPALCRRISEVLAGERCQPRQVRRAAISMASYLLRWQQRPTPFGLFAGVAAVRITDAAKAAWRGTHRTVARADACWLAGIIERLNGCPPLVDRLTVVASNAGQVRGDRYVVPGLPGEQPQELAPVEVSVRHTRPVAAALDAARMPIRYGELRALLAQQFPAAPVGRIDAMLGGLVARDILISSLRAPMTRLDALGHVCDLLEAAEAHTIPDITDLVTELYALRHELSRSVVIDARPARSDLADRMQALSDVASVPLVIDTGLDCDVEIPEHVAVEAQEAVNVLHRVSAHPSGSPAWRDYHARYRTRYGPDAVVPVLDLVADSGLGLPAGYLGSAYKTAARQMTERDEKLLALVQQTILDGAPEIILTESLITELSDADTPTRCAPYAEVAVEVHAASPEDLARGAFRLLVTGTPRPASSMAGRFAHLLPAQTRAQLADAYRAAAPGALAAQLSFVPRKRRNENVARTERLLPQVISLSEHPMPDQSVIPLSDLAVTADTRHLFLVRLSTGMRIEPRVAHALEAGVHTPPLARFLGEISTARCAVYRYFDFGAAARLPYLPRVRHKRTILAPARWLLTGPDLPGPGAPGHAWDAAFEAWRTRRRVPDLVTLAEHDQRLRMDLTHPVHRLVLRTRLNATGHLELREAATARDLAWLGRAHELLLPLALANPTPARIPERTLVPTVTADAGHLPGHSTVLAAHLHAHPDRYDEILTGHLPSLIDSLQGTPLWWFNRQRTTPRPDADQHLALYLRLPEPDDYSRTAEQLHAWTRQLRRQRLVAQLTLATYQPPTGQYGHGPALEAAYEVFAADSAAALAQIRMTTRGGTDPLALSAASMVDLAARLAPSAADGLTWLTEQLPHEPGRLDRSLREQTLDIADPYGRRTTLRARPCGDEVAAAWQARAATLAAYREHLAGQRQPFTVLRPLLRLHQTRTLGPDPTLRRITARLARACALRYTAGTTQ
>NC_017586.1|WP_014141307.1|636577_636775_+|FxLD-family-lantipeptide
MPDVLLPDNTRLADDPADDDFTLDVRIVVATGPMAGYADCPTDDGCGNTCANGASACDSYIGDPA
>NC_017586.1|WP_014141306.1|635285_636563_+|methyltransferase,-FxLD-system
MTDVTSDHEHAARLRDAVVDELVDRGEIVSKDVEAVMRKVARHAFTPEASLEDAYHTYNAVVTKRNEHGRAVSSVSAPQIQAFMLEQAEVRPGMRVLEIGSGGLNAAYLAELVGNTGEVTTVDIDPEVTERAARLLAQAGYPDVRVLLADATEGVAAHAPYDVIMVTVGSWDIPPAWIEQLTATGRLVVPLRIRGLVRSVAFQRQGNRLVSTSARICGFVSMQGAGAHEADLLLVNGTEEIVLRFDDGLPADPGQLNNAVRSPRVEISTGVLVRRMEPVDTLQLYMATVLPGFCTMSVDAGLDTGLVAPRNKGFSMACVEGANFAYITTRIAEDDAFAEFVVHAFGPGGPTLAEAIADHVRTWDREHRGGPGPRITLYPAGTPDDQIPELPGGRVIDKTHCRVTLSWSPTATAAEDRATQHHTTE
>NC_017586.1|WP_014141305.1|633924_635070_+|methyltransferase-domain-containing-protein
MTWRDRARDLAATLEKTGDLHDHRWRAAVEEVPRHEFVPAFYLPGDDDPGVWHRVGVDHDGYLDAVYTDQTLVTYLDPHTAANAGTGLAGVPSSSSTRPGLVVRMLETLGVEAHHAVLDIGTATGYQAALIAHRLNASGRLTTADIDPLFTTHAQAALQLLGYTPEVVTCDATTYLWSEMFDRIISGCALPRITDTLRAALRPGGRLIAPLMPPLGCALVVLTAEDHGVLEGRFLPGQVAVMPARQHPASYPAPAAGPGVTAATITGTSTVPVEAFDDPCFLFLLAGHLPGVDLQTGDGDTVPVRRLVMPDGSWAEGRFAPHQPVLWREVGDHRIRRTLNRCWTWYLQHDRPAFDRFGLTITSTGTHRLWFDSPNHVLTSF
>NC_017586.1|WP_014141304.1|632953_633802_+|hypothetical-protein
MTSTRMPTTTAVPDHDFRALMSKRAAGWSRRKPPSAFRYGFPFHAVPQVLAHFTAKQHSEPWLAGRLVRSLAADIARWQGVWSLHQPSGLYRLDDRGPGSLCHALLIDPAGVILAYTTSHSDAACRRTGIPAPPAGQPWLASTTERIPPDGAVNVWRHILRVSTSAPIAVSGAAYNGYKDCRTHDPGTHPLPQTMPNWYLAAQASATRLAPLIPHSPGQTYRIHDGTGLAWLIRIPTHPGRKPTALRVQMSPADEPKIIPLAPRAAAQAMTDPQVSLQDADR
>NC_017586.1|WP_014141303.1|632264_632957_+|hypothetical-protein
MDSDADVFVLHDVPNWPQEDLDCLARSGYRLERAVMTDRPGYHTLLLCRPPWYTRGVWNLAGRHFHPGLVRMRLIHLPPDPGQDLYGISGLRPAEEGAEVLLMALHMSERGRRLMRRATAAPGLAGGELVAAVEQLSVQAEAEHGPDWARWPEPPHTRPAGQPVDPTFGLHDPAAPRVLILSHCTTDDDTGPETADQVVISGAASSTVHCPPAPTSADDQMCLVDLEIPR
>NC_017586.1|WP_014141302.1|631206_632109_+|endonuclease/exonuclease/phosphatase-family-protein
MKSVVTFATFNLEQNGFGCRERREQAYALINKVRPDVLFRQEMPGADADYHQHVREAEQALAMVGYLGEGSRTALFVRPGLFDVLKGWPSPQPVTMSAPTALTVQLRAAGPASTPLILVADHLSYSTPTLRLIGAGELTRFNDKWVVLPDGTRRRGLAVAGLDANSYPSGEFLTAEPRLPRVEEIQDRPHRAHRTVLAADGRRVMDQAPHDFLVTAGLDDVARVCAAHSPGAVAATMGPSITHGPATRVDWVMASRHLRDAWVGGEVIDASTVSDHNIFVGRADLQILVDILSGPLPEFG
>NC_017586.1|WP_014141301.1|630432_631071_+|hypothetical-protein
MTPTKRPLVVPYIAPWSGERTAAHLLVHDARGTGIVYADEHPFDRDSHGVLYKRTLHRPGVGDPLLGDVHGPRQRRAMRKLLCQVCGRAADRDARGWLWLLRADPRTPEWPEGEMTTHPPLCRRCARISVRQCPHLNDQAVAARVGRPEIDHVLAVRYRKGGTAPEPAGHADVVPIADPAIRWYLATQLVATLTGCTVVDLKTELGDRSSAV
>NC_017586.1|WP_014141314.1|644070_644388_+|PadR-family-transcriptional-regulator
MASIRLTRPTLEVLQVLLASTDDDPAWGLRICEEAALGSGTVYPILDRLTERGWIASQEEVVPHPGRPARRFYTLTGTGRKLAEEAVRSRLGQRGTPSPALGADA
>NC_017586.1|WP_014627360.1|645408_645615_+|hypothetical-protein
MRVYAEGAWRRAWVLQRQDWPDGRTAYMLDVLLPSRPPIPGDPHSQDYFVRTYWWGTGSMTPVKRSSS
>NC_017586.1|WP_014141317.1|645595_646327_-|hypothetical-protein
MTTARAQTVTTATATRQGSRPCNADAAAVHRVPGTRLIGAAVVDGIGSNPAVARLAEIAAEVIARVAPRKTPVLGILAAAELVAAPADRNPIDPDAVAVAAVAEPGRRTGIAWTGDARAYGWDGTTLTQLTTDQTVGEYLRANSGGGGPVELLAQAHDNWLRASLGRSSISTVHTVGTDARLVLLTSDGVHDHIPHKVLEALVREHAENAQALVEAVVEVAEPDETGYRDDATAVVLVTTTTA
>NC_017586.1|WP_014141318.1|646449_646755_-|hypothetical-protein
MTPENPHGETEAGVTIQYSVKELIEGLHRKLDSLMTLLHGKADSVTVKALEVRMDRVEEHIATQTHHRELEEKRADWRRWLIPTLATLILAAATVASLLKT
>NC_017586.1|WP_014141319.1|646877_648275_-|hypothetical-protein
MPRTMYDAVTPANIPANATMVAGYADGRYANLDELRARFPAATIISIAVRWTTRAQVLDVESGDATPEQAVQWCTQTMADTPNHELTVYCNTSQWPSVRAAFQAAGITEPNYWVAAYDGDPTIPAGAIAKQYLGDYHGYDKSAVVDYWPGVDTSPPPGGEFYPGANRSHWYEQAYPGDPMRVNTIIWHSTETTVLPDYGGGSIAPTLTAVPNWREQRLDWWQHFPFDTSARALVHDRALIGTNTLNVAQIEIVGTCDPATHAAWTQAGIQHLYMPALPGWAVRDLAACARWAHTTHGVPLTSGLRWLPYPASFGANNGVRMDAAAWSAFRGHAGHMHVPQNDHGDPGVFPIAAILSNTPVLEDDMPQWHTGPITAGSEPTVVLVPHGNAWQAAPKRTLHLGMDQLGAPAATATVRVAVHNGIRWGAVSTVKVTAAGSTVDVDVTGAVKVSLQTTTTGLAYAVETW
>NC_017586.1|WP_014141320.1|648286_648730_-|hypothetical-protein
MPTHPHRQVAAHDQSVTHRYVMHYPAHAPREGDPHYRAFELYRRHHRQGAVCYVGERAGHDQCAGDLELHHSVLEFAVVNAVDAAALHKDFPEVREDATAEEIAQWAESSPGQFRWLCAYHHRGAGGAHTASHADWSAQLYVPHLIS
>NC_017586.1|WP_014141322.1|648962_649304_-|hypothetical-protein
MDRIRAFNERLADWITAALSSMWAAYLFTGLALVSLPQALAGGIAPTVTWTAQTFIQLVALAVLGAGQDKQTRRWAATLRETHDAVLQQLEGVTELVAALHAKHDAVHSPEPS
>NC_017586.1|WP_014141323.1|649377_649791_-|hypothetical-protein
MTPHHTASAKVVVRSIGTRHPDAIGLLRSGLYFDLGHLRNPHADRIMRYKTGLSEDVRAHVLSTPGATHLAVQIAEAAKAQLYSFANRNQDPVTVTLACSGGRHRSVVMAEQVAEYLDIDDVPAAVEHLHIHASVIE
>NC_017586.1|WP_014141324.1|649872_650286_-|hypothetical-protein
MTHTCARCGAPSAVQWLRRPTPGEHTAINATAAQRRAEILELADPDRPPPIGPGLTEATDHTVAVYACSTHTITLDLATRIHASTCTAPHESDLPQCDCTPEPPPKPQPRPGDPGTMVTLPTGWVVPAPAERAPSGP
>NC_017586.1|WP_014141325.1|650296_650839_-|hypothetical-protein
MGLAPPVIATQAPGNFITGALWNSQVANGLTFLLGPPVFVGVQGAATQSLANTATTAINLDTNVIDFYGGHSTSFSTSRYVCQQPGYYTVSGTVVYTANATGMRGAHACVNGASNPIQGCAAQVPAGPTYNTAVALPARDVYLNQGDYVEIYGWQSSGGTLSTQYAADQASMLYLRFSHS

Crispr_ID: NC_017586_2

• CRISPR_ID: NC_017586_2
• CRISPR_location: 1576297-1576394
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_017586_2

Consensus_repeat	Method
CCCCGTCTCGTCGTGGCTGGCGTCAC	CRISPRCasFinder

spacers of NC_017586_2

>2.1|1576323|46|NC_017586|CRISPRCasFinder
GCTCGCGCTGGCGGTCAGCCATTACCTCCCCGGGGGTTCGCCCGGT

CRISPR arrays and Neighbor proteins around NC_017586_2

CRISPR arrays

The CRISPR arrays of NC_017586_2

>merge|NC_017586|2|1576297-1576394|CRISPRCasFinder
CCCCGTCTCGTCGTGGCTGGCGTCACGCTCGCGCTGGCGGTCAGCCATTACCTCCCCGGGGGTTCGCCCGGTCCCCGTCTCGTCGTGGCTGGCGTCAC

>NC_017586|2|2|1576297-1576394|CRISPRCasFinder
CCCCGTCTCGTCGTGGCTGGCGTCAC	GCTCGCGCTGGCGGTCAGCCATTACCTCCCCGGGGGTTCGCCCGGT
CCCCGTCTCGTCGTGGCTGGCGTCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017586.1|WP_014142215.1|1577938_1578721_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|377092
NC_017586.1|WP_014142219.1|1581807_1582704_-|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl|CDD|213022
NC_017586.1|WP_014142208.1|1571626_1572295_+|HAD-IA-family-hydrolase	unknown	unknown	gnl|CDD|319829
NC_017586.1|WP_014142224.1|1587474_1587699_+|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl|CDD|274226
NC_017586.1|WP_014142223.1|1586185_1587430_+|hypothetical-protein	unknown	unknown	gnl|CDD|274008
NC_017586.1|WP_014142217.1|1579482_1580142_+|membrane-protein	unknown	unknown	gnl|CDD|223659
NC_017586.1|WP_014142220.1|1582741_1584892_-|aminodeoxychorismate-synthase-component-I	unknown	unknown	gnl|CDD|223225
NC_017586.1|WP_014142203.1|1565371_1566820_+|glycine-betaine/L-proline-transporter-ProP	unknown	unknown	gnl|CDD|182611
NC_017586.1|WP_014142222.1|1585346_1586114_+|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl|CDD|372574
NC_017586.1|WP_014142213.1|1575441_1576209_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|131480
NC_017586.1|WP_014142218.1|1580230_1580986_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142211.1|1573611_1574478_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|375319
NC_017586.1|WP_014142206.1|1568569_1570807_-|MFS-transporter	unknown	unknown	gnl|CDD|341045
NC_017586.1|WP_014142205.1|1567386_1568541_+|acyltransferase	unknown	unknown	gnl|CDD|224748
NC_017586.1|WP_014142210.1|1572724_1573543_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187639
NC_017586.1|WP_014142216.1|1578857_1579310_+|DoxX-family-protein	unknown	unknown	gnl|CDD|225168
NC_017586.1|WP_014142212.1|1574487_1575387_+|aldo/keto-reductase	unknown	unknown	gnl|CDD|381314
NC_017586.1|WP_014142214.1|1577105_1577690_-|TMEM165/GDT1-family-protein	unknown	unknown	gnl|CDD|225030
NC_017586.1|WP_014142204.1|1566877_1567207_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142207.1|1570896_1571472_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017586.1|WP_014142215.1|1577938_1578721_-|ABC-transporter-permease	gnl|CDD|377092	pfam03649, UPF0014, Uncharacterized protein family (UPF0014).	2.46281e-42
NC_017586.1|WP_014142219.1|1581807_1582704_-|polysaccharide-deacetylase-family-protein	gnl|CDD|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	8.27664e-29
NC_017586.1|WP_014142208.1|1571626_1572295_+|HAD-IA-family-hydrolase	gnl|CDD|319829	cd07527, HAD_ScGPP-like, subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). This subfamily includes Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). GPP1p and GPP2p are involved in glycerol biosynthesis, GPP1 is induced in response to both anaerobic and hyperosmotic stress, GPP2 is induced in response to hyperosmotic or oxidative stress, and during diauxic shift; overexpression of DOG1 or DOG2 confers 2-deoxyglucose resistance. These belong to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.68817e-67
NC_017586.1|WP_014142224.1|1587474_1587699_+|zinc-ribbon-domain-containing-protein	gnl|CDD|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	3.32387e-11
NC_017586.1|WP_014142223.1|1586185_1587430_+|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00103495
NC_017586.1|WP_014142217.1|1579482_1580142_+|membrane-protein	gnl|CDD|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	4.19854e-15
NC_017586.1|WP_014142220.1|1582741_1584892_-|aminodeoxychorismate-synthase-component-I	gnl|CDD|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	4.66237e-136
NC_017586.1|WP_014142203.1|1565371_1566820_+|glycine-betaine/L-proline-transporter-ProP	gnl|CDD|182611	PRK10642, PRK10642, proline/glycine betaine transporter ProP.	0
NC_017586.1|WP_014142222.1|1585346_1586114_+|DUF4097-family-beta-strand-repeat-protein	gnl|CDD|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	8.08341e-09
NC_017586.1|WP_014142213.1|1575441_1576209_+|alpha/beta-fold-hydrolase	gnl|CDD|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	3.95872e-26
NC_017586.1|WP_014142216.1|1578857_1579310_+|DoxX-family-protein	gnl|CDD|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.51193e-11
NC_017586.1|WP_014142206.1|1568569_1570807_-|MFS-transporter	gnl|CDD|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.45281e-79
NC_017586.1|WP_014142205.1|1567386_1568541_+|acyltransferase	gnl|CDD|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	1.24802e-26
NC_017586.1|WP_014142210.1|1572724_1573543_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187639	cd08934, CAD_SDR_c, clavulanic acid dehydrogenase (CAD), classical (c) SDR. CAD catalyzes the NADP-dependent reduction of clavulanate-9-aldehyde to clavulanic acid, a beta-lactamase inhibitor. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.47816e-91
NC_017586.1|WP_014142211.1|1573611_1574478_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.04718e-54
NC_017586.1|WP_014142212.1|1574487_1575387_+|aldo/keto-reductase	gnl|CDD|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	7.61022e-138
NC_017586.1|WP_014142214.1|1577105_1577690_-|TMEM165/GDT1-family-protein	gnl|CDD|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	7.02347e-25

Protein sequences

>NC_017586.1|WP_014142213.1|1575441_1576209_+|alpha/beta-fold-hydrolase
MLLPFDEAGQGQPVVLLHARPTDRTMWRAHLPLLAEAGVRAIALDLPGHGDSPLPDHREVAPWADVLDTLDHLGVDRFVLAGNSLGALVALQTAVTAPERVRGLALIGYRPHDLPPSPRLQTAWDREKTALDADDIEAAVQAGVDSWTSPNASDEVRAHAADMLRRQLTSQLAHGEPNLATDPLSQNADALRTLAIPALVGVGELDMPDFFQGGKSLADELDAGDLVVVPNAGHLAPLEQPEAFCALLLNAFRSR
>NC_017586.1|WP_014142212.1|1574487_1575387_+|aldo/keto-reductase
MTTSLADSVGTFEIAGKKVARLGFGAMRLTGLGVWGEPDDRGECVRVVRRAVELGVQLIDTADSYGPYVSEEIIREAIHPYSDDVLIATKAGLTRNGPDVIRRGGELVRLGPAAWPPVGRPEYLRQQALMSLRRLGLDHIDLFQLHRVDPKVPLEDQVGELKKLQDEGKIVAIGLSQVTVDQIERARRVADIATVQNRYNLTDRTSADVLAYCTRHGIGFIPWAPVAAGELARPGGTADRIASAHGTRPSHVALSWLLASSEVMLPIPGTSKVAHLEDNVAAAHLRLSEAEIAELDAAA
>NC_017586.1|WP_014142211.1|1573611_1574478_+|helix-turn-helix-transcriptional-regulator
MDSKNELGDYLRARRALIRPEDVGLPDYGPRRVPGLRRDEVALLVGVSTDYYIRLEQGRERHPSDQVLRAIAGALRLDDAAAAHLYRLGMPVFGTKTSTSTTVAPELLRLMEGMQDVPAFLVGAAQDVLAANAMARELYCGFARYDNLLRMIFLDPYAKEFYADWEAAARIAVGNLRASSSQFPEDERIQRVVGELTLRSPAFTNLWARYEVRPRTHEDKHFRHPRVGELRLHFEALAVASAPGQHLSVYSAEPGSASADALVLLRRLAEQSATAADPSNEDIPIQKE
>NC_017586.1|WP_014142210.1|1572724_1573543_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTSYPDTADLAPETHRASALRPLAGTVALVTGASSGIGEGTALALAALGASVTVAARRTGRLDALVETIEGTGGRALAVTADITDERQADATVARAVETFGRLDVVVANAGVMLLGPLAGADTTEWRRMIELNTLGLMYTAHAAVPHLLDSAAHGPRQVADLVLVSSTAGRQVRDGSGAYNASKYAVTAFGEALRRELTRRHVRTSLVEPGAVETELPEHNRPEIQQRMRERYSTMERLTPADVADAIAFVVTRPRHTAVNEILIRPTEQQD
>NC_017586.1|WP_014142208.1|1571626_1572295_+|HAD-IA-family-hydrolase
MTRRSQTLGVFKAALLDMDGTLVNSDAVVERCWRRWADEHGLDPAEVLKVVHGRQGYATMAVLLPERPMAENHADNARMLAEETADVDGVVPVPGAPEFLAALAGLPHALVTSADEALARARMDAAALPMPEVRVTAESVSASKPDPEGFLKGAAELGFAPEECVVFEDSEAGISAGLAAGMTVIGVGPRAAALSPTAHVPTLEQVAVSPAAEGGFTLALLS
>NC_017586.1|WP_014142207.1|1570896_1571472_+|hypothetical-protein
MATEFGPRGLQLVLLRRMADHRPELVEEALRELGASRSEMREANRHWQATLRARTFPRGEARHRLLLGAPESVAERRIGDVTCRALRWPVPLWPGLRFEVMSGPGGRVWNEWLVRAPGATPPAPREVADLRPWSYVVDEVARAFPAARPLEGDAPTRWRLAFADPGTGERHVAHFTYGLLQTVEPQVGGVG
>NC_017586.1|WP_014142206.1|1568569_1570807_-|MFS-transporter
MANGHPGEPLILDRGAAMARDDAIRPEGTAPGSPGGSVPDHPDRPASGVPAGRPPTGAGTAEPSGPGNVPGDVPGDTPRRIVLVAMSALLMGMLLAALDQTIVSTALPTIVSDLGGLNHLSWVVTAYLLASTAATPLWGKLGDQYGRKRLFQTAIVIFLIGSALCGIAQNMGELIVFRALQGLGGGGLMVLSMAIVGDIVPPRDRGRYQGLFGAVFGASSVLGPLLGGLFVDHLSWRWVFYINLPIGVVALGVIAAVLHIPVHRTKHTIDYAGTAAIAAVATCLVLVASLGGTTWPWASWQIVVLAVAGVVLLALFVAIERRAAEPVLPLRLFRLRAFTLCSVIGFIVGFAMFGAMTYLPTFLQVVHGISPTLSGVHMLPMVLGMLISSTGSGQIVSRTGRYKVFPVLGTGITIGGLYFLHTLDEFTGTWTMSAAFFVFGFGLGLVMQVLVLVVQNAVGYADLGVATSGATFFRSIGASFGVAIFGTVFSSELRTQLTGALAGRALPPGLTPQALQSDPHTVAALPPAVRGAVLHSYAVAITDVFLYAMPVAAVAFALAWFLREQPLRASVTAPDVSETYASNPVERSSRDEVARALSWLGTREGRRGLYRRITELAGLDLHPAASWLLLRINRYGSAAPQLLGERTDVPPEVVYQASAELEIAHLVRREGLVLVLTDAGREVAGRLVDVRTSVLAELLGDWWDPKRARDDLHGLLRELSGQLCGDDSDRPMPRQAPPRRAAATT
>NC_017586.1|WP_014142205.1|1567386_1568541_+|acyltransferase
MGTAMPVHDSPPLPPVAVTAATPSAAAPTGPGRRPRLYVLDGLRLLAALYVVAYHYTAFAEHDPHPWGRPVHEVFPVFNRFSSYGFLGVQLFFLISGFVICMTAWGRTPKDFLISRVTRLFPAYWFAIAATTVFVLLAGGHWLRYGRGIDQFLTNLTMLQDPLKVSDVDGVYWTLWCELVFYLLFLVVVRAGLSYQRVVSFCGIWLVAGVISTGSGDSIVRTLTMPGQAPYFAGGVAIYLMHRYGPDLLLAGLTGLCWLLSLHQLATQLPEVSGHVGHHLQFGYAAAFVTACYAVLIAAALGRLDWIRWRGLTTLGALTYPLYLLHEDIGWGVILHLHDTVPAWALVGGVTAFFLYAAWLVHRYVERPLARYLKRGLSKPRPAR
>NC_017586.1|WP_014142204.1|1566877_1567207_-|hypothetical-protein
MNEHDGHAAPDSGSGPRRVLDEVRAAETERRTRQALDDFADHPRRAVQELDTLLAEACGWFTDALTDRRHALRQHWRGEGGSASTTVGPDDLRHALAEYRDLLLRLSRL
>NC_017586.1|WP_014142203.1|1565371_1566820_+|glycine-betaine/L-proline-transporter-ProP
MTTHPDTLKAETRWPPNRGVGGTADRARPVTVVDQKMVKRAVTAAALGNAMEWFDFGVYSYIAVTLGEVFFPSGNPTAQLLSTFGAFAAAFLVRPVGGMVFGPLGDRIGRQKVLAITMIMMAVGTFAIGLIPSYAAIGVGAPLLLLAARLVQGFSTGGEYGGASTFIAEYAPDKRRGFLGSWLEFGTLVGYVAGASIVAVLTAVLSHDALLAWGWRIPFLVAGPLGLIGLYLRLKLEETPAFARLEQEARAKQVEQSAKKSLREILLGQWRAMLLCVALVLVFNVTDYMLLSYMPSYLTGQLHYGATHGLIVVLVVMVVMMAVQPLAGRLSDRFGRRPVIGAGCAGFLLLSIPALLLIRQGSLAGVYAGMAALGLLLVCFTGAMPSTLPALFPTRIRYGALSVGFNISVSLFGGTTPLVVTALISATGNLLMPAYYMMAAAVVGGVAVLLMSETAGRPLKGSPPAVATEAEARELAATPQAA
>NC_017586.1|WP_014142214.1|1577105_1577690_-|TMEM165/GDT1-family-protein
MFSLTIAAIVFGVIFVAELPDKTALASLMLGTRYRAGYVFCGIAAAFAVHVVVAIAAGSLLTLLPHRWVQGVVGVLFLAGAAMILWQHSGDEDEETMKPPADQSFWKVAGSGFMLILVAEFGDLTQIMTANLAARYGDPLSVGIGAVLALWAVAGIGILGGRALMKRVPLRLITKIAAAVMVALAGFSLYEALS
>NC_017586.1|WP_014142215.1|1577938_1578721_-|ABC-transporter-permease
MAVSAAASATTLLPVNAMLGVVLAALLLAAVAVACYARFVDDRENYPRAIAYAGLRAVVQLAVVALVIGWVVRRLPTLLAFVLVMYAVAVRTAGRRITRNGTWWWASVPIAVGALPVVALLVAVGLVPLKGVALIPVAGILIGGALTATVLAGQRALDELRSRHGEVEAALALGLLERDARLEIARPAAATALIPGLDQTRTVGLVTLPGAFVGMLIGGASPVMAGAVQLFVLVALLAVQAVAVTVVLELVARGRITRPR
>NC_017586.1|WP_014142216.1|1578857_1579310_+|DoxX-family-protein
MRLSADTAKPHVLALFRVVTGLLFACHGAASLFGVLGGAAGTHGGTLPAGAWPGWYAAVIQFIGGVLVVLGLGTRAAALISSGSMAYAYFSVHAKLALWPLQNGGEPAALYSWAFLLLAVTGPGAWALDGIFSAARRRRPAAPAEAGSPA
>NC_017586.1|WP_014142217.1|1579482_1580142_+|membrane-protein
MVDRLTALVDSPWAFALVALSVLLDVFLPVLPSGVLLTSAATVGTAGADGAKDATDIVALLLCASAASCLGDLAAYRLAWRGGAWLDRRLERSRRLAAAQERLGQVLTQGGGALVVLARFAPAGRSVVSLGAGAAHRRPAEFLPWSALAGFVWAAYGVGLGYIGGHWLGASWVSTAMSLLALAGAGAVAAYVFRRERRTLATPDLPVPAQDLPVPADLR
>NC_017586.1|WP_014142218.1|1580230_1580986_-|hypothetical-protein
MDDTREHVERLLDRAHNAFELDDAVVARLRGALMHCVELHSLHRRNGPPYPLGHRTLRHVFLLPDGADLVLWEIEYTTGPGSRTLHEVYADQAQAAEAERRMTAWCGTEPYPRADTDADAALQDLLSGILDDLAIPGRSRSRHTYEHDRSAEHAWRVLRRAENPDRPGARIRRLLRTAVGHETTLVAMRHARDEGPAVEWALYEHAFLLADDSELSLWEVEHFPPDGYPVCEVYLDETTARDSAERRREAL
>NC_017586.1|WP_014142219.1|1581807_1582704_-|polysaccharide-deacetylase-family-protein
MKRHNGLSRVHSTTAGVAALAAVATLATGCGGGADAAGKPSPAPTASGAPASGTPSAPAGGDGTASVPAAVWHKWGLKPLPAPPAPPADKPVKLTAHGPVPVFAHIPTHQKVVFVTLDDGQEKDPKFIAMMRELRIPVTMFLMNDAIKSDYGYFKPLQALGNHIQNHTLHHPAMNTIPLARQTEEVCGDQKILTKQYGTAPLLFRPPYGAYDTATKAAVNACGPRAIVWWRESMQITNMQYQAPDKKLRPGDIILAHFRGPSELKGTTMTEMFANLIRRIEEQGFTVARLEDYVAAPS
>NC_017586.1|WP_014142220.1|1582741_1584892_-|aminodeoxychorismate-synthase-component-I
MRTLLIDNYDSFTYNLVHQIAAATGQEPEVVRNDDPGWRAGRLDGYDAVVISPGPGTPRRTSDFGICDEVIARCERARLPLLGICLGHQGIAARHGGTVERAPEPRHGRTSPVLHDGTGLFAGVPSPFEVVRYHSLAVTDLPDELRATAWTEDGVLMALAHRERPVWGLQFHPESICTRHGDLLLRNFTALARAERAAHPRPPVTVRAPEPTPAPAAPPRELEVLAERIPTRWDAEVVFDRLFRERPYAYWLDGGGPGSGLSADGTGRFSVLGDATGPLARVATADVWTGTVTVRERGREQLVTGSFLDWLDADLRGLRTTCPELPCDFALGWVGYLGYELKAECGGERAHRSPDPDAVLVFTDRAIVLDHATGTTYLLALAERGARSQARAWLRETRRRLAALAGAAPGPAPRPQPAAHGIRLRHDRARYLELIAEAQEEIAAGETYEVCLTNTADIPGPVDAWQAYRLLRRLSPAPFGALLSFGGLSVLSTSPERFLRIGADGVAESRPIKGTRPRGATAAEDEALRAGLAADEKDRSENLMIVDLVRNDLGRCAVTGSVVADDVFRVESFRTVHQLVSTVRARLRPGASAVDCVRSAFPGGSMTGAPKVRTMRIIDRLEGGPRGVYSGVIGYFSLTGAADLSIVIRTAVVTERGIRYGTGGAIVALSDPAAEFEETAVKAAPLLALTATEFPGRADAGAPGAGQGTDPAVSRS
>NC_017586.1|WP_014142222.1|1585346_1586114_+|DUF4097-family-beta-strand-repeat-protein
MASAHRIRMGFRAPLLATVLGLALAGCGHAVADRGPAEHRSFAFTGKRLTIETTEGSLVVEAADVRKVEVTRWFRGRAVLGVTPRATWDLTGATLALRTHCAGVVSSCSIRHKVLVPRGLAVAVRAGDGKVEAEDIGTPLNISTANGSVQVKDCSGDLTLTSHNGKVTATGTGARTVRARSGNGSVQLGFATVPDRVDVTSGNGKVTVELPPASYDVTARSSNGSTHVDVPVKRHSGHVVTVRVKNGSATVRTAT
>NC_017586.1|WP_014142223.1|1586185_1587430_+|hypothetical-protein
MATARSWWRRDDDSHRAAARSAKDAAAESFYELDTAQRELTLTIETITAVDRSPGGRKAKADYDSLARRIDEVSGGYIAAVDAHDLDAEQLDLAAATRARNAFTLARDEIVKVRADLDRFARSLGPMLTRAENELSRLAPAVEQARQALLGATGALDEVRAAGLRADDLAARLAALGPELTKLNAGAKAHGVRETIQRADAMRRAAGEIRAEAEALPQRAAEIDRRLVSLRTRAQALTTRAGQVGPTLSELRRRFSAACWQDLQQVPERAADAVARAERRLAEAERARAEQRWPDATAALTAVRDLLAETDAAVSAAGDRLRRLDEVSRDPQGEIERTRFALRDAQRLAMQGRATPDPRHAGPLDDGVARLQRAVDGLTGRHPDYWAFLTELAAIRETAEDVVAAIREERARTS
>NC_017586.1|WP_014142224.1|1587474_1587699_+|zinc-ribbon-domain-containing-protein
MPRYEYRCRACGTTFEMNRPMAQSSDPAACPHGHDDTVKLLSTVAVTGTATSGAGAARAPQGGGGGCCGGGCCG

Crispr_ID: NC_017586_3

• CRISPR_ID: NC_017586_3
• CRISPR_location: 1726809-1726895
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_017586_3

Consensus_repeat	Method
CCGCGCTACGCCTCGACCGCCCCCGCG	CRISPRCasFinder

spacers of NC_017586_3

>3.1|1726836|33|NC_017586|CRISPRCasFinder
GCCCCCACCTCCCGGGGGACGACCCCCGTACCC

CRISPR arrays and Neighbor proteins around NC_017586_3

CRISPR arrays

The CRISPR arrays of NC_017586_3

>merge|NC_017586|3|1726809-1726895|CRISPRCasFinder
CCGCGCTACGCCTCGACCGCCCCCGCGGCCCCCACCTCCCGGGGGACGACCCCCGTACCCCCGCGCTACGCCTCGACCGCCCCCGCG

>NC_017586|3|3|1726809-1726895|CRISPRCasFinder
CCGCGCTACGCCTCGACCGCCCCCGCG	GCCCCCACCTCCCGGGGGACGACCCCCGTACCC
CCGCGCTACGCCTCGACCGCCCCCGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017586.1|WP_014142369.1|1738988_1739621_-|ComEA-family-DNA-binding-protein	unknown	unknown	gnl|CDD|224472
NC_017586.1|WP_014142364.1|1733426_1734020_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_017586.1|WP_014142357.1|1724661_1725492_+|DUF3097-domain-containing-protein	unknown	unknown	gnl|CDD|378628
NC_017586.1|WP_014142351.1|1716299_1719563_-|S41-family-peptidase	unknown	unknown	gnl|CDD|227282
NC_017586.1|WP_014142368.1|1736487_1738992_-|ComEC/Rec2-family-competence-protein	unknown	unknown	gnl|CDD|225212
NC_017586.1|WP_041825034.1|1735118_1735364_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142352.1|1719637_1720393_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl|CDD|236959
NC_017586.1|WP_014142349.1|1714885_1715785_-|ribonuclease-Z	unknown	unknown	gnl|CDD|234602
NC_017586.1|WP_014142350.1|1715806_1716166_-|histidine-triad-nucleotide-binding-protein	unknown	unknown	gnl|CDD|238607
NC_017586.1|WP_014627646.1|1728958_1729363_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142365.1|1734054_1735044_-|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl|CDD|236130
NC_017586.1|WP_014142354.1|1721521_1722664_-|molecular-chaperone-DnaJ	unknown	unknown	gnl|CDD|237654
NC_017586.1|WP_014142367.1|1735981_1736440_+|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl|CDD|132706
NC_017586.1|WP_014627645.1|1725502_1726735_-|coproporphyrinogen-III-oxidase	unknown	unknown	gnl|CDD|180172
NC_017586.1|WP_014142362.1|1731712_1731979_+|30S-ribosomal-protein-S20	unknown	unknown	gnl|CDD|376586
NC_017586.1|WP_014142363.1|1732301_1733237_-|NADP-dependent-oxidoreductase	unknown	unknown	gnl|CDD|176191
NC_017586.1|WP_014142356.1|1723904_1724621_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293840
NC_017586.1|WP_014142361.1|1729558_1731427_-|elongation-factor-4	unknown	unknown	gnl|CDD|235462
NC_017586.1|WP_014142355.1|1722664_1723684_-|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl|CDD|234621
NC_017586.1|WP_014142353.1|1720389_1721457_-|2-nitropropane-dioxygenase	unknown	unknown	gnl|CDD|367316

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017586.1|WP_014142369.1|1738988_1739621_-|ComEA-family-DNA-binding-protein	gnl|CDD|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	2.04343e-22
NC_017586.1|WP_014142364.1|1733426_1734020_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.67455e-12
NC_017586.1|WP_014142357.1|1724661_1725492_+|DUF3097-domain-containing-protein	gnl|CDD|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	9.35754e-161
NC_017586.1|WP_014142351.1|1716299_1719563_-|S41-family-peptidase	gnl|CDD|227282	COG4946, COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown].	1.27342e-113
NC_017586.1|WP_014142368.1|1736487_1738992_-|ComEC/Rec2-family-competence-protein	gnl|CDD|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	1.28429e-52
NC_017586.1|WP_014142352.1|1719637_1720393_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl|CDD|236959	PRK11713, PRK11713, 16S ribosomal RNA methyltransferase RsmE; Provisional.	1.54995e-71
NC_017586.1|WP_014142349.1|1714885_1715785_-|ribonuclease-Z	gnl|CDD|234602	PRK00055, PRK00055, ribonuclease Z; Reviewed.	2.59147e-114
NC_017586.1|WP_014142350.1|1715806_1716166_-|histidine-triad-nucleotide-binding-protein	gnl|CDD|238607	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.	1.06201e-51
NC_017586.1|WP_014142361.1|1729558_1731427_-|elongation-factor-4	gnl|CDD|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_017586.1|WP_014142365.1|1734054_1735044_-|DNA-polymerase-III-subunit-delta	gnl|CDD|236130	PRK07914, PRK07914, hypothetical protein; Reviewed.	5.12027e-87
NC_017586.1|WP_014142354.1|1721521_1722664_-|molecular-chaperone-DnaJ	gnl|CDD|237654	PRK14278, PRK14278, chaperone protein DnaJ; Provisional.	0
NC_017586.1|WP_014142367.1|1735981_1736440_+|pyridoxamine-5'-phosphate-oxidase	gnl|CDD|132706	TIGR03667, Rv3369, PPOX class probable F420-dependent enzyme, Rv3369 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	1.56254e-05
NC_017586.1|WP_014627645.1|1725502_1726735_-|coproporphyrinogen-III-oxidase	gnl|CDD|180172	PRK05628, PRK05628, coproporphyrinogen III oxidase; Validated.	0
NC_017586.1|WP_014142362.1|1731712_1731979_+|30S-ribosomal-protein-S20	gnl|CDD|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	2.35707e-22
NC_017586.1|WP_014142356.1|1723904_1724621_+|MBL-fold-metallo-hydrolase	gnl|CDD|293840	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.46834e-47
NC_017586.1|WP_014142363.1|1732301_1733237_-|NADP-dependent-oxidoreductase	gnl|CDD|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	7.12095e-74
NC_017586.1|WP_014142355.1|1722664_1723684_-|heat-inducible-transcriptional-repressor-HrcA	gnl|CDD|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	3.60403e-157
NC_017586.1|WP_014142353.1|1720389_1721457_-|2-nitropropane-dioxygenase	gnl|CDD|367316	pfam03060, NMO, Nitronate monooxygenase. Nitronate monooxygenase (NMO), formerly referred to as 2-nitropropane dioxygenase (NPD) (EC:1.13.11.32), is an FMN-dependent enzyme that uses molecular oxygen to oxidize (anionic) alkyl nitronates and, in the case of the enzyme from Neurospora crassa, (neutral) nitroalkanes to the corresponding carbonyl compounds and nitrite. Previously classified as 2-nitropropane dioxygenase, but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. One atom of oxygen is incorporated into the carbonyl group of the aldehyde product. The reaction appears to involve the formation of an enzyme-bound nitronate radical and an a-peroxynitroethane species, which then decomposes, either in the active site of the enzyme or after release, to acetaldehyde and nitrite.	1.19041e-94

Protein sequences

>NC_017586.1|WP_014627645.1|1725502_1726735_-|coproporphyrinogen-III-oxidase
MPSVLPDGEPMPADGSLPGHALAGAAGRPLGFYLHVPYCATRCGYCDFNTYTASELRGSGGAPASRDNYAETLVEEVRLARKVLGDDPRQVATVFVGGGTPTLLAAEDLGRMLAAIRDEFGLAPGAEVTTEANPETVDPAYLERLRAAGFTRVSFGMQSARQHVLRILERTHTPGRPEKCVEQARAAGFDHVNLDLIYGTPGESDDDWRASLDAAIGAGPDHVSAYALIVEDGTRLAHRIRRGEIPMTDDDVHADRYLIAEQALSDAGFHWYEVSNWATTKAGRCRHNELYWRGADWWGAGPGAHSHVGGVRWWNVKHPGAYAQALAEGRTPGAGREVLTDEDRRVERVLLELRLADGCPLDLLRPDGARAAARALADGLLQPAPYQAGRAVLTLRGRLLADAVVRDLVD
>NC_017586.1|WP_014142357.1|1724661_1725492_+|DUF3097-domain-containing-protein
MRSRSYGPDLTPPWKRSKPAPEVAAEPDLVVEEVGTGFCGAVVRCEKTAEGVTVTLEDRFGKHRVFPLVPRGFMIDGQVVTLVRPAPAGRAPAGPRLTASGSIAVPGARARVARAGRIYVEGRHDAELVERVWGDDLRIEGVVVEYLEGVDDLPGIVAEFAPGPDARLGVLVDHLVPGSKESRIAERVGGPDVLVVGHPFVDVWQAVKPAAVGIPAWPTVPRGQDWKTGVCRALGWEEHTGAAWRRILASVRSYKDLEPELLGAVEHLIDHVTTPA
>NC_017586.1|WP_014142356.1|1723904_1724621_+|MBL-fold-metallo-hydrolase
MEKTERDGWERLAPGVARRRLAFLDVTIGVVVGTDGVLLIDSGSTVPEGERLRREVRDLTGRDVTHLALTHAHFDHVLGASAFPEAAVYGQAGLAGVLARGRAELGEDAVRYGVAGPEARRAVDALVTPGHPVDRRHALDLGGREALLVHPGPGHTGHDLAVVVPGTPVVVFCGDLVEESGEPQAGPDAVPGRWPAALDALLELGGETAVYVPGHGAVVDARFVRAQRDALARRFAVG
>NC_017586.1|WP_014142355.1|1722664_1723684_-|heat-inducible-transcriptional-repressor-HrcA
MLSERRLEVLRAIVQDYVGTEEPVGSKALTERHKLGVSPATVRNDMAVLEEEGFIQQPHTSAGRIPTDKGYRLFVDRLAGVKPLSAAERRAIQNFLDGAVDLDDVVARTVRLLAQLTRQVAVVQYPSLTRSTVRHVELLSLAPARVMLVLITDTGRVEQRLVDCPAPVGETVLADLRARLNSRVVGRRFTDVPSLVQDLPDSFEHDDRPTVSVVLATLLETLVEETEERIMLGGTANLTRFAHDFPLTIRPVLEALEEQVVLLKLLGEGAKDSGVTVRIGHENAHEGLNSTSVIAVGYGSGDEAVARLGVVGPTRMDYPGTMGAVRAVARYVGQILAES
>NC_017586.1|WP_014142354.1|1721521_1722664_-|molecular-chaperone-DnaJ
MATDYYAVLGVRRDAGQDEIKKAFRRLARELHPDVNPDPKTQERFKEINAAYEVLSDPQKKQIYDLGGDPLSASGGAGGAGAGGFGAGFGNFSDIMDAFFGTASQRGPRSRTRRGQDAMIRLEIELDEAAFGTTKEIQVDTAVTCTTCAGEGAAPGTAAQTCDMCRGRGEVSQVTRSFLGQVMTSRPCPQCQGFGTVVPTPCPECAGDGRIRSRRTLTVKIPAGVDNGTRIQLAGEGEVGPGGGPAGDLYVEIRELPHQVFQRRGDDLHCTVTIPMTAAALGTKVPLETLDGLEEVDIRPGTQSGQSIPLHQRGITHLRGGGRGDLVVHVEVQTPTKLDAEQEELLRRLAVLRGEERPSGHFQPGQQGLFSRLKDAFNGR
>NC_017586.1|WP_014142353.1|1720389_1721457_-|2-nitropropane-dioxygenase
MPTLTELLPLPVVQAPMAGGASGPALAAVVSGAGGLGFLAAGYKTPEAVRREIAEVRALTARPFGVNVFLPQPAADPAAVAAYAARLAPEADRYGTALGDPGAGDDDAYDAKVALLLADPVPVVSFTFGCPEPAVVEALRRAGTYTVVTVTSAAEAVAARRAGADAVCAQGTEAGAHQGRHHDDPGRDATATTLQALLPAVREAAGLPVIAAGGIMDGRGIAAVLAAGAEAAQLGTAFLATAESGAHPLHKRALTDPGYDRTELTRAFSGRPARGLVNRFLREHGPAAPAAYPAVHHLTSPLRKAAAAAGDTEAMALWAGQGHRLARELPAAELVRVLAAELAEARGARTPGRAR
>NC_017586.1|WP_014142352.1|1719637_1720393_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MTAPVFVVPPGALPAAPGTRVVLDGPEGRHAVSVRRLRVGEEIVLTDGEGTGAYGTVAAVEGKDWLEAEVAEVRREPDPAPRITVVQALPKGDRGELAVETMTETGVDAVVPWAAGRCVTQWKGERGVKALAKWRATAREAGKQARRLRFPVVHDLMTTRQVAGLLAGADFAAVLHEEGAAPLAAAPLPKRGEIVLVVGPEGGVAPDELAAFADAGAAPCRLGPTVLRTSTAGVAATALLLGRTGRWGAPD
>NC_017586.1|WP_014142351.1|1716299_1719563_-|S41-family-peptidase
MTHPSYLRYPHPHGDLITFTAEDDVWAAPLDGGRAWRVSADNMPVDHPRISPDGEHIAYTSTRDGAPEVHFAPVDGGPAKRLTYWGSWQTRVLGWTPRGEVLAVTAHGEVSSRRTWARAVPLDGGPARTLPYGPVGGVAFGPDGAVLLQSVSMGREAATWKRYRGGTAGKLWLDPDGTGTFHRVHAALDGNIECPLWVSGGGGPARIAFLSDHEGTGALYSSLPDGSDLRRHTPLDGFYARHAATDGTRVAYTSGGRLHLLDSLDAEPRPLQVRLGGQRTDLQPYPVRAAHHLGDAHPDHTGRGSAVEVRGTVHWLTHREGPARALAATPGVRARLPRVFRKGGEGEPHVVWVTDAEGEDALEFAPATGSGAETGRTDATAPPHRLAAGRLGRVLELAVSPDGRRVAVASHDGRVLLVERETGEVRRVSDSEHGEASGLVFSPDSGWLAWSQPGPAPLRQLRLANTTTLAVCDATPLRFNDFSPAFTADGKHLAFLSERAFDPVYDAHVFDLSFPNACRPYLITLAADTPSPFGPQRHGRPLGGGADDRAEGERHDEGHPEDGERRVPVTRLDLDGLADRIVPFPVEAGRCSTLRAAAGGVLWLRHPLHGVLGAALATPQATPPATTLERFDLDRLRAEELAEDVDDFAVTGDGRRLLLTSGGKLRVVPSDAKADDEDGDSAVTVDLSRIRVTVEPAAEWRQMYAETGRLMRDNFWRPDLGGVDWDGVLDRYRPLLDRVATHDDLCDLLWEVHGELGTSHAYVVPPRGRGDALHRQGLLGADLVRDGDGVWRVARVLPSETSDPGARSPLAAPGVAVRAGDALLAVDGRPVDPVAGPGPLLVGTAGKPVELTVVGATGEPRAVVVVPIADEEPLRYHDWVAGRRAHVHERSAGRLGYLHVPDMQGYGWAQLHRDLRIEVAREGLVVDLRENRGGHTSQLVIEKLVRRVVGWDVPRGARPSSYPLDAPRGPVVAVADEFSGSDGDIVNAAIKELGIGPVVGTRTWGGVVGIDSRYHLVDGTLVTQPKYAIWFDSLGWDLENHGVDPDIEVVPTPQDRVAGRDVQLDTAIEVALERLAAQPARTPPALP
>NC_017586.1|WP_014142350.1|1715806_1716166_-|histidine-triad-nucleotide-binding-protein
MAGDPQADCLFCKIVAGDVPATIVHENDTTVAFRDINPQAPTHVLVIPKAHYPDAASLAEQAPQLAADVLATAGQVAAAERVDGTGYRIVFNTGGGAGQTVFHAHAHLLGGRGLNWPPG
>NC_017586.1|WP_014142349.1|1714885_1715785_-|ribonuclease-Z
MRELVVLGTASQVPTRHRNHNGYLLRWDGEGILFDPGEGTQRQMLLAGVAAHDLTRICVTHFHGDHSLGVAGVVQRINLDRVPHPVTAHYPASGSRFFERLRYATAYRQTAVIRQEPVIGDGELAVTPAFTLTARKLSHPVDSYGYRLVEPDGRRMLPEKLAAHGIAGPDVGRLQRDGELRGVRLEEVSEVRRGQRFAFVMDTRLCDNVHALADGCDLLVIESTFLGPDEALADEYGHLTAAQAARVAAGAGVRHLVLTHFSQRYPDPEAYAAEAREAGFTGELTIARDLDRVPFPKRR
>NC_017586.1|WP_014627646.1|1728958_1729363_-|hypothetical-protein
MSDSAMARRMLLAAAGSAVALGSACPAAMAASADAFDGRHLSANQGAGCASHTLALVGDHVLHHGRLPKVFNHYRGGGLPVDGVAALCEAVDEKEAKDGRQGPLGLLGGLPLHGNPLNAVHQLPVGASPLGHTG
>NC_017586.1|WP_014142361.1|1729558_1731427_-|elongation-factor-4
MPATPSHVPEPSRTDPALIRNFCIIAHIDHGKSTLADRMLQLTGVVEQRQMRAQYLDRMDIERERGITIKSQAVRLPWAPTSGEGKGTTHVLNMIDTPGHVDFTYEVSRSLAACEGTILLVDAAQGIEAQTLANLYLALENDLTIIPVLNKIDLPAAQPEKYAAELAHIIGCDPSEVLKVSAKTGEGVAELLDKVVAEVPAPVGVADAPARAMIFDSVYDSYRGVVTYVKVVDGRLSKRERIQMMSTGAAHELLEIGVSSPEMTAADGLGVGEVGYLITGVKDVRQSKVGDTVTRLHKGATEALGGYKDPKPMVFSGLYPLDGSDYPELRDALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHLDVIRERLEREFGLDLIATAPNVVYRVIMEDGSEHTVTNPSEFPVGKIDEVYEPVVRATVLAPSEFVGAIMELCQSRRGSLLGMDYLSEDRVELRYTLPLAEIVFDFFDQLKSKTRGYASLDYEPTGEQISDLVKVDILLHGDKVDAFSAILHKDKAYAYGVRMAGKLRELIPRQQFEVPIQAAIGSRVIARETVRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGNVEVPQEAFIAALSTDEGDAKARK
>NC_017586.1|WP_014142362.1|1731712_1731979_+|30S-ribosomal-protein-S20
MANIKSQIKRNKTNEKARLRNKAVKSELKTAIRRTREAVEAGNAEKATEAARAAARKLDKAVSKGVIHKNQAANKKSALASSVASLKG
>NC_017586.1|WP_014142363.1|1732301_1733237_-|NADP-dependent-oxidoreductase
MNAIRFHEYGEATDVLRLERADVPVPGPGEIRVAVHACGLNPADWALCRGLFTGQLPRGIGLEVSGTVDAVGAGVTGVAVGDTVLGAADYAGGHSAGAADFAVLTHWAHVPEGLDLVQAAALPMAVETAYRSLEQLAVTAGRTLLVHGAGTMIGFAAVQIALDRGARVIAAAGPTYAERLRALGATVTSYGDGMAERVTAAAGGPVDLVLDTAPPGGVLPALVRVADGDPRRVLTVSDPDGVGLGVRTSFDEDASKALRYDVLGEFAQRAAEGRFSIPVARVFPLADWRTAAETSLGGRARGKLVLLLDRS
>NC_017586.1|WP_014142364.1|1733426_1734020_+|TetR/AcrR-family-transcriptional-regulator
MPRDGRPARLRLQKAAAELFGEHGFDRVTTAEIAARAGVTERTFYRHYADKREVFFASEADLRDALVAGVADAPEELEPLPALLWAFRTVVPVMEENRPLVEPMRRVIADTPALRERHQAKTAALTDALATALHGRGVAGPTASLAARVAMAAMSHAAAVWFVNPGHDLDRLLRDTFADVHALTAALAASDAEAARR
>NC_017586.1|WP_014142365.1|1734054_1735044_-|DNA-polymerase-III-subunit-delta
MAKKSSTDDVLAPVTLAVGQEDLLLDRAVAEVVAAARAADPDTDVRDLTPDALQPGTLAELVSPSLFAERKVVVVRNAHDLSADTVKDVKGYLDAPAEEITLVLLHAGGAKGKGLLDAARKARAREVACAKLTKPADRLAFVRAEFRTAGRSATPEACQALVDAIGSDLRELASACAQLGADVEGTVDAAVVARYYTGRAEATGFEVADLAVTGRTAEALERLRWALAVGQPLPGITFALASGVRAIGKLATAPRGARPGDLARELGMPPWKIDRVRQQMRGWSGDGVAMALRAVAEADAAVKGAGADPAYALEKAVVTISRAARSRRG
>NC_017586.1|WP_041825034.1|1735118_1735364_+|hypothetical-protein
MSNVRHVLVLPDRDAAHEAAEEAVSRFGLDDDPDIVREALAGEDDAEDAQWLVVIEDEPGELDPAELESLAEEYDGWREEE
>NC_017586.1|WP_014142367.1|1735981_1736440_+|pyridoxamine-5'-phosphate-oxidase
MTHPESPRSLALRKRQALHRLDHDQDVWVATADGDGVPCLVPLYFWWDGHAVWIATRGTNPTGVNLSRSGLARLSFGHTRDVVLMAGTATDFARDGLPAGVGDAFAAKFGWDPREDHPSYRYFRIVPELIQAWGTVAEMADRTLMRDGRWLL
>NC_017586.1|WP_014142368.1|1736487_1738992_-|ComEC/Rec2-family-competence-protein
MTTGTSPEETTGPADLRLVPPACAAWGAAAVTLGVPGRWTAAVAAGALAVALAVWVRLRGRGGDGRSGVAGVAVATALCACAAACSAGLAATALHRGPIPRLAARGAEATVDVTLTGDPHRTSARPPDAMPAPPVVVARAEAVRVAADGVTTTVRTPVLLIAEPGGSGRSGGSGERSPPGGADAWLRLLPSTTLRLTARLDRSDRPGDDIAALAVVHGAPRVIAGPSRLHRVAGSLRAGLRAATAQLAPDVRALLPGLVVGDTSGVPPDLRAAFDATDLSHLLAVSGANLTLVLALFIGPPALATRAERRGLAARSGLSLRRTAVLGAVLTAGFVVLCRPEPSVLRAAVCGLITLAAIGTGRRRSLLPALAATVLVLVLADPWLARSFGFALSVLATGALLTLAPRWAEGLRRHGVPPRAAEALGAAAAAQACCAPVIAVLAAHVSLVAVPCNLLAEVAVAPATVAGFAALAVAPVSLPAAKALAWLAGWPVRWVAWVARTGADLPGARLGWPGGWRGGLLLAVVTVAAVGLVRRIRPRPWMYAALVVALLVAVVRPAPLTRFATGWPPPGWRMVVCDVGQGDALVLNSGSGTGVVVDAGPDPVLADRCLRALGITRIPLLILTHFHADHVAGLPGVLRGRAVGAIETTTLDSPAPEAASVVRAAAAAHVPLVRAAAGERRRLGALEWQVLWPPPAPAELPDEGPNDASVALLVTVAGLTLALLGDLEPAAQQEVLARNPGLPRADVLKVAHHGSAHQDPALLARLRPRLALISCGAHNRYGHPSPRTLDALHAQGATVLRTDTAGSIAVTGRDAPVPGAGPPALSASVVKGAS
>NC_017586.1|WP_014142369.1|1738988_1739621_-|ComEA-family-DNA-binding-protein
MEPRTVVALAGVLVVVVAFAVHHFWAGRPRTVQVPAVVRGGAPVVARAAGASEGTAARATATVVVDVAGRVRRPGVARLPAGSRVVDALKAAGGAVPGTDTGALNLARLLVDGEQIRVGGPAPPDAPPDPAVGPAGPSAATGSVPGAGPVSLSTATLEQLDALPGVGPVLARHILDYRTQHGPFTSVTQLRRIPGVGDRRYKTLEPLVRP

Crispr_ID: NC_017586_4

• CRISPR_ID: NC_017586_4
• CRISPR_location: 1805082-1805341
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NC_017586_4

Consensus_repeat	Method
CATCCCCGCCGAAGCGGGGCCAA	CRISPRCasFinder

spacers of NC_017586_4

>4.1|1805105|20|NC_017586|CRISPRCasFinder
CGAAAAGCGTGCAGCGGGAC
>4.2|1805148|48|NC_017586|CRISPRCasFinder
CATCCCTGTCACTTGAACATCAGGGATGCATGTTCACTTGTGAAGGAA
>4.3|1805219|38|NC_017586|CRISPRCasFinder
ACTTGCGCCCGACAACCCCTGCAAGGCGACTCTCGGGC
>4.4|1805280|39|NC_017586|CRISPRCasFinder
CGTTGTGCCCTGTTGAGCCATGCAAAGCGACTCTAGGGC

CRISPR arrays and Neighbor proteins around NC_017586_4

CRISPR arrays

The CRISPR arrays of NC_017586_4

>merge|NC_017586|4|1805082-1805341|CRISPRCasFinder
CCACCCCCGCGCAGCGGGGACAACGAAAAGCGTGCAGCGGGACCACCCCCGCTAACGCGGGGACAACATCCCTGTCACTTGAACATCAGGGATGCATGTTCACTTGTGAAGGAACATCCCCGCCGAAGCGGGGCCAAACTTGCGCCCGACAACCCCTGCAAGGCGACTCTCGGGCCATCCCCGCCGAAGCGGGTCCAACGTTGTGCCCTGTTGAGCCATGCAAAGCGACTCTAGGGCGACCCCCGCAGAGGCGGGGTCAA

>NC_017586|4|4|1805082-1805341|CRISPRCasFinder
CCACCCCCGCGCAGCGGGGACAA	CGAAAAGCGTGCAGCGGGAC
CACCCCCGCTAACGCGGGGACAA	CATCCCTGTCACTTGAACATCAGGGATGCATGTTCACTTGTGAAGGAA
CATCCCCGCCGAAGCGGGGCCAA	ACTTGCGCCCGACAACCCCTGCAAGGCGACTCTCGGGC
CATCCCCGCCGAAGCGGGTCCAA	CGTTGTGCCCTGTTGAGCCATGCAAAGCGACTCTAGGGC
GACCCCCGCAGAGGCGGGGTCAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017586.1|WP_158693794.1|1804310_1804658_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142444.1|1800411_1801641_+|hypothetical-protein	unknown	unknown	gnl|CDD|379657
NC_017586.1|WP_014142451.1|1805767_1807771_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142456.1|1810833_1811079_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142448.1|1803604_1804327_+|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl|CDD|119373
NC_017586.1|WP_014142449.1|1804715_1804946_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142443.1|1799415_1800399_+|phage-tail-family-protein	unknown	unknown	gnl|CDD|368574
NC_017586.1|WP_014142457.1|1811075_1811336_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142450.1|1805384_1805657_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142447.1|1803351_1803540_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142442.1|1797981_1799397_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_078590659.1|1797771_1797969_+|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl|CDD|381605
NC_017586.1|WP_014142445.1|1801641_1802724_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_157894818.1|1809449_1810067_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142455.1|1810382_1810796_-|hypothetical-protein	unknown	unknown	gnl|CDD|378714
NC_017586.1|WP_014142452.1|1807908_1809432_-|DUF3987-domain-containing-protein	unknown	unknown	gnl|CDD|379041
NC_017586.1|WP_157894819.1|1811332_1811569_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142459.1|1811639_1812068_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142446.1|1802727_1803261_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014142454.1|1810146_1810386_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017586.1|WP_014142455.1|1810382_1810796_-|hypothetical-protein	gnl|CDD|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	3.82925e-06
NC_017586.1|WP_014142444.1|1800411_1801641_+|hypothetical-protein	gnl|CDD|379657	pfam14594, Sipho_Gp37, Siphovirus ReqiPepy6 Gp37-like protein. This family includes numerous phage proteins from Siphoviruses. The function of this protein is uncertain, but it is related to pfam06605. In Rhodococcus phage ReqiPepy6 this protein is called Gp37.	4.95061e-79
NC_017586.1|WP_014142452.1|1807908_1809432_-|DUF3987-domain-containing-protein	gnl|CDD|379041	pfam13148, DUF3987, Protein of unknown function (DUF3987). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	3.25852e-09
NC_017586.1|WP_014142448.1|1803604_1804327_+|LysM-peptidoglycan-binding-domain-containing-protein	gnl|CDD|119373	cd00599, GH25_muramidase, Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family of muramidases contains a glycosyl hydrolase family 25 (GH25) catalytic domain and is found in bacteria, fungi, slime molds, round worms, protozoans and bacteriophages. The bacteriophage members are referred to as endolysins which are involved in lysing the host cell at the end of the replication cycle to allow release of mature phage particles. Endolysins are typically modular enzymes consisting of a catalytically active domain that hydrolyzes the peptidoglycan cell wall and a cell wall-binding domain that anchors the protein to the cell wall. Endolysins generally have narrow substrate specificities with either intra-species or intra-genus bacteriolytic activity.	3.65892e-39
NC_017586.1|WP_014142443.1|1799415_1800399_+|phage-tail-family-protein	gnl|CDD|368574	pfam05709, Sipho_tail, Phage tail protein. This family consists of several Siphovirus and other phage tail component proteins as well as some bacterial proteins of unknown function.	2.56707e-19
NC_017586.1|WP_078590659.1|1797771_1797969_+|transglycosylase-SLT-domain-containing-protein	gnl|CDD|381605	cd13402, LT_TF-like, lytic transglycosylase-like domain of tail fiber-like proteins and similar domains. These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	1.3172e-28

Protein sequences

>NC_017586.1|WP_014142449.1|1804715_1804946_+|hypothetical-protein
MNEFIKKHAVRAFAVLAALVPVLVDQWPGIPWEALAAVVAAILGVGEVTQRHWDARLNAPVEPAAEVPAEPAGPAV
>NC_017586.1|WP_158693794.1|1804310_1804658_-|hypothetical-protein
MQMQGPDGDVEVEEEDSGACDVADQEGTRILSEQCGTCILRAGTPVPPQAVRRVIRSALEADGHVVCHETAVRGVPAAVCRGFVDRYGDQALSIRLAHVIGIREIPPPSSLTSRF
>NC_017586.1|WP_014142448.1|1803604_1804327_+|LysM-peptidoglycan-binding-domain-containing-protein
MIKGIDVSSYQSTDFDTDGLDFVFIKATEGTSYVNPRMAGQAATARAAGLVVGFYHYISPGDMSAQAAFFVDRCDSVPGDVLFADWEEPGVSCAQKDQFIREVKRLRGSNHKVGLYCNQDYWLNRDSSSYAGDALWIADYVTPGRPRIQANWLFHQYTDRPLDTNVASFANRAALRSWAGGSSAPAPKPTPGPVTYTVRSGDTLSGIAQKYGTTVAKLSAANGIKDPDMIFAGQVLKIVK
>NC_017586.1|WP_014142447.1|1803351_1803540_+|hypothetical-protein
MKYHTGRVWQAEAEAQKARADRLQDDLAEIKERLARIEAENSRLLEILSVIDPERIAALRHP
>NC_017586.1|WP_014142446.1|1802727_1803261_+|hypothetical-protein
MRQLFGGTASDFAEDAAGTRVPGAIGTVWDGPSTGAQQYTDLTTADGAPMYQLTADSRGFVPAFFGPDGVERLWVDFGAGRVALTSVTVGERLDAHTSALDPHGDRAYADGAFLKNSGNGLEVTPDGKAIVSHVPHQFTGPLRLCSASGDLLGELYAEGGALKWRSSAGTVTTIAPA
>NC_017586.1|WP_014142445.1|1801641_1802724_+|hypothetical-protein
MGNEISYPFSSDSAGGGQQMVSQAQWQMMSRMFGPDRIDTQLVSSSYDGSALPFAASVVNGTSVSVSPGRALVGGFYYQLTAAQSVAIAANTGTNPRVDLIVLRADLAAGSVNLAVVQGQAAASPVVPQPTRTLGGRWELPLHQVTVPGNNGTLSVLSVGPFDMPSPVAVPWNASQLAQVTPVGTYIYDLDSNTNDTQSEYFVGRDGVAVTRHLGKARPYTPSLVNATDPLPTSYRTGRWRIIAPGMVWFAVTINNQNDGGAMLSGKNWIMGITLPPVPAATATRQVLHGHITNARGGGNLPNYMSVTALIEQGGTGQTTAYLYYPSPTTPAQGLDALPGIPAGAILTLSGVYQTNVYGD
>NC_017586.1|WP_014142444.1|1800411_1801641_+|hypothetical-protein
MGYRVEVRDAALNRIGVIDTWIKLDLVVRYCQTGSWQVLVEAGTPQADLLQKGGGVAIYQDGVKDPVLTGQIEAFQHYWTNDQHTSLGSLYFGGKCDNKLAYNRLAFPDPAKDATQQWQADDTRKVKGPAGQLIWSELNQALGPGALPSRQIPGVVIGSNVPSGPTLSDNLRWDVIGTKLESWIDTKTTGYRFLYDPNAKAINFHPFTPRDLSQDIRFSTELGNLREFTWALTAPTVTRVIVACQGAGKSRYLYQQTDTASEAEWGLQIEQFLDRRDLPIKADPTTGQPIKADLSVSDTDFQTALQAVKDAANEALTNGAKNGNFQIYPIDTDHVKFGRDYFVGDIVTVAVDGTEYVDIVREVSITVEQGGQTETVAPSIGEQGSGNPLNLYKTVFEMREKLRRLEARM
>NC_017586.1|WP_014142443.1|1799415_1800399_+|phage-tail-family-protein
MPIPAAVTSPNDAWSGDLTVPVPVEWQSTYVSIRGNNGQGEEIPLTGFLSAAWPAIMLQPGATGLDMPPFEIHADDSPNLDGSMYRGARAAARDILLPLYVYGIDRLTLRQFKRDLANALNPKSGYCVLTFIESDGIPRRLRCYYKGGMEGSEAADSAGFRWVSYGIQLTAMDPWFYGDTQVVASWSFGKPQPFLGKFLPLRLGKGTLATNTLQVSNPGDIEAWPVWRISGPVKSLILTGPDGSSWGIPAQASGADVIPIGRTLTVDCRPGYKTVTDDQGKNYFPLLAANPSLWPVPPGTSTVATNLVAGSGTAAVTMTLDPRYASY
>NC_017586.1|WP_014142442.1|1797981_1799397_+|hypothetical-protein
MQALAGTAGYASGTSGARPGWAWVGEEGPELVRFGGGETVLNHRDSMRAATRGLPGYASGTKSGVAVDAEKGASSLSAAVKRLYEIITKAFTSGRIGQGTENSLNRWLDGENKALSNLVKQRTDLAGKLKAAQAALKKVKDDEAKMASGISDKASSLRDLSSVFNSDGVSVTAGLSGLHERLAAIKKFQANLNTLVKRGFSSAIIENIAEAGPEQGGAMAQELLNATGAQIKDYNKTYAAIGTASDSLGNSVAKSYYATGEKAAQRLVDGLMSKDKVLVKKIESLADSIVRTLKRTLNFGSTTPVTSGLGALLTWLTGESQSVGRKPKPKPKPKPKPTPQVKRTVTTTTGYDSKGRSVTTVTTTITDPWAGTTTTITERTVDGRTTTTRSVRRTTKGYATGTLSASPGMALVGERGPELVDFRGGERVYTARQTADLMGPRYEIHIHEAKAENTTQAVLRALKYAEVMSGM
>NC_017586.1|WP_078590659.1|1797771_1797969_+|transglycosylase-SLT-domain-containing-protein
MQVESGGNPNAINLWDSNALAGMPSQGLMQTIPPTFDAYAGPYRSLGITNPLASIYAGLNYAIHR
>NC_017586.1|WP_014142450.1|1805384_1805657_-|hypothetical-protein
MRGVDPNGDTGDGGVILSEGEYMTLALLEVTGPARPTATHKRSYPVLGELIDAGYVEVFGSIYESTRVITEVGREALRKHREAGPGGQNE
>NC_017586.1|WP_014142451.1|1805767_1807771_-|hypothetical-protein
MREHVVHPLYYHRGDGHGPERLCDELTCRLCQHDCDCAACRELVDAPGLRVLVDSHDELPEGSIMTEVRESAATRAVMAELAREVGMWSSAGESFDMSDLPTYRDQAMRWLKQHSELSTRVIEGADYAVALTHYRMWTGWSPAADLEKREKKEMISVDMPAQLRKHAARLNGATKGERELTEACSRAVEAMREAGRSPNEGGTVQLTNAALGAALTVARGWLNSKNGNEMRAAKSLLSRHEMDYVPDDPREIRHEVKLPKSLSELMRRSFSHGQLRGRDDLLAELTAMSWTEAGAKGRVTVDGLRWLLDRARHFEGHDHPAVKRAATTFVQRYTPDHERTSKLVDAYLAAGDEHQDQEQQSPTEPERVVLVACGGAKAALDRAAAGDMYVGSYHRACRRAAEALTKDGGTVLILSARYGLLPLDQEIETYDVRAGEPGAMQPDALRDQAASMGLTDARVTVLGGSAYVELARSVWPQAEAPLNGGIGDQLQQLASIYGGDPEPLDETPETMPTAAPMKWYTGPLREVGGLPTRYQPRLHRMWFGGKAGRKGKAPGPWRRVEVTYTGDSVYELADLETGEVLLNAKLSTRIHWAALPGNWEVAQEVEAELVADEDQDDEPELPTKAGKSSRPLRQVPENFLYIAEEADTEAARAWWRRRCEQYARGEV
>NC_017586.1|WP_014142452.1|1807908_1809432_-|DUF3987-domain-containing-protein
MSTDATSPFAAMKYGPMGEAVERAMPTSEADPIGVWAAALSLYSSAISRTVRLENGRPVVVWTVLAGRSAIGRKGYALGTAKSMLRPVIGGYLDVRLEDGIASGASLVQMLYRLELETSGSRGGPDGRACIVEEEWASVLRMQKRDTKFSTLFRSAWDGKTISNRTKKELQIVPRPLLGFHAHITPGEWAAYVSKSDALGGSYNRLLPVLVERSKMLPHNNRWKFGDAKPLANAFQWATATERVMVFDTPAGKRYDVIRAEIEDRMVELPELLASYMERAAEQVHRIAAVLAATEKRTKIPRKAVDAAWAFVQYSMASVEKLVKEAAESGSRPLKTIEDLIRDALARYGGEATSTLLLRALGTRANAAAVKEAVEGMEDVEVYKAQTVGRGAKPIMYRLVEPAAGDQTEESPTEPETVVPSAAEKPERKATRPTLRVVRPARTLDPVHQDEPQQPVKAKPVKPLPKKTKKKAKPTGPKKAVTKKAVAKPKPAPAPAPADVNPIAALL
>NC_017586.1|WP_157894818.1|1809449_1810067_-|hypothetical-protein
MPADYRETQVSVYGRAVIVRTEKDGTIRTDKQLEAAHFNRVKAKLEELHAVGKRKKAAQLRLLGTKARGLRSHPRTGNLEEASKVYEAEALMVEKRKFSKPTCDFRDARRPFPKVTFTYPVIPEHLLEMHEEIAPRDIVMVTRGDDMASRVISSVVCDACATKQIEREGSVKLTIGDDEYDLCGEHGERFRAWFADALKPAQAAA
>NC_017586.1|WP_014142454.1|1810146_1810386_-|hypothetical-protein
MSYTKRWADDVKDVQEQAVRGRELPTARERLVALRELFEECGYLARVYPCPCRAAAELVSVAAAAWQESAPDEPAVTAA
>NC_017586.1|WP_014142455.1|1810382_1810796_-|hypothetical-protein
MSGVDEPARTPGEVPEDYDPEDVAAWCLRQRWFTTGPWDTEFQKREIHPKVLALYRKDRARELEREKRGAAERTRLAQMWAEAAAARERAAEQARRMRDMRRWGPENGYFVGTRGCIPRRVVEAYNQAHGIEEGDSS
>NC_017586.1|WP_014142456.1|1810833_1811079_-|hypothetical-protein
MSGMKRYVEERWKAEGRIGEYRRIAELHAADTVDGLLVDAWTAAACVTLHDALSERNRARWLAMSTAQQCEVAVRLTMGGR
>NC_017586.1|WP_014142457.1|1811075_1811336_-|hypothetical-protein
MTTSTRWIATFDEEAGQLDIYSSNGPGPMYTWRRRHDLTHAIQTLILWSWEHPTNGWRTAPQWERLGESSVMVADAWPVRISVEDR
>NC_017586.1|WP_157894819.1|1811332_1811569_-|hypothetical-protein
MGKGSTKSEVQHFQRLDDGRTGCWTWNCGKAATRWIDMERYGIRRWLSKAYCDGHGNDEFKDSHHTYRVRQIKEGNNK
>NC_017586.1|WP_014142459.1|1811639_1812068_-|hypothetical-protein
MSWGYEVWVCDCGYTKPAEHDGSCGIWKRTAIHWNDRWFGAFEEAAQHGHAYVMAVPVGATLERGWKAHITFEHIRGGGLCKECRKRRGPLTTTPFGKKFMCEDCRSAFRRDHERNAYVTGRDPDSRLYRPVLDVAQEDAKH

Crispr_ID: NC_017586_5

• CRISPR_ID: NC_017586_5
• CRISPR_location: 2666458-2666541
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_017586_5

Consensus_repeat	Method
ACCTCGACGCAGTTGCCGCCCTGG	CRISPRCasFinder

spacers of NC_017586_5

>5.1|2666482|36|NC_017586|CRISPRCasFinder
TCACCGCTGTAGCTCGACTTGCGCCAGGCAAGGGCT

CRISPR arrays and Neighbor proteins around NC_017586_5

CRISPR arrays

The CRISPR arrays of NC_017586_5

>merge|NC_017586|5|2666458-2666541|CRISPRCasFinder
ACCTCGACGCAGTTGCCGCCCTGGTCACCGCTGTAGCTCGACTTGCGCCAGGCAAGGGCTACTTCGACGCAGTTGCCGCCCTGG

>NC_017586|5|5|2666458-2666541|CRISPRCasFinder
ACCTCGACGCAGTTGCCGCCCTGG	TCACCGCTGTAGCTCGACTTGCGCCAGGCAAGGGCT
ACTTCGACGCAGTTGCCGCCCTGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017586.1|WP_014143283.1|2671058_2671484_+|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl|CDD|235383
NC_017586.1|WP_014143265.1|2656267_2656993_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187585
NC_017586.1|WP_014143286.1|2673008_2673572_-|FABP-family-protein	unknown	unknown	gnl|CDD|378046
NC_017586.1|WP_014143284.1|2671499_2672468_-|folate-binding-protein-YgfZ	unknown	unknown	gnl|CDD|223431
NC_017586.1|WP_014626964.1|2667473_2668244_+|IS5/IS1182-family-transposase	unknown	unknown	gnl|CDD|372577
NC_017586.1|WP_086010087.1|2663572_2664765_-|IS3-family-transposase	unknown	unknown	gnl|CDD|222853
NC_017586.1|WP_014143268.1|2658531_2659074_-|DUF3291-domain-containing-protein	unknown	unknown	gnl|CDD|378694
NC_017586.1|WP_014143285.1|2672520_2672952_-|transcriptional-repressor	unknown	unknown	gnl|CDD|223806
NC_017586.1|WP_014143280.1|2668360_2669029_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014627918.1|2665045_2665423_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014143267.1|2658057_2658339_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014143264.1|2655823_2656249_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176106
NC_017586.1|WP_014143288.1|2673814_2674177_+|hypothetical-protein	unknown	unknown	gnl|CDD|224955
NC_017586.1|WP_014143282.1|2670299_2670932_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014143266.1|2657091_2657997_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|182137
NC_017586.1|WP_014143281.1|2669252_2670221_-|asparaginase	unknown	unknown	gnl|CDD|377601
NC_017586.1|WP_041824660.1|2659345_2659879_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_106433172.1|2660826_2661216_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014143274.1|2661356_2662859_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|377587
NC_017586.1|WP_014143279.1|2666581_2667391_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017586.1|WP_014143283.1|2671058_2671484_+|D-tyrosyl-tRNA(Tyr)-deacylase	gnl|CDD|235383	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional.	1.74302e-85
NC_017586.1|WP_014143265.1|2656267_2656993_-|SDR-family-oxidoreductase	gnl|CDD|187585	cd05324, carb_red_PTCR-like_SDR_c, Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs. PTCR is a classical SDR which catalyzes the NADPH-dependent reduction of ketones on steroids and prostaglandins. Unlike most SDRs, PTCR functions as a monomer. This subgroup also includes human carbonyl reductase 1 (CBR1) and CBR3. CBR1 is an NADPH-dependent SDR with broad substrate specificity and may be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds. In addition it includes poppy NADPH-dependent salutaridine reductase which catalyzes the stereospecific reduction of salutaridine to 7(S)-salutaridinol in the biosynthesis of morphine, and Arabidopsis SDR1,a menthone reductase, which catalyzes the reduction of menthone to neomenthol, a compound with antimicrobial activity; SDR1 can also carry out neomenthol oxidation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.19344e-87
NC_017586.1|WP_014143286.1|2673008_2673572_-|FABP-family-protein	gnl|CDD|378046	pfam08768, DUF1794, Domain of unknown function (DUF1794). This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.	1.0185e-62
NC_017586.1|WP_014626964.1|2667473_2668244_+|IS5/IS1182-family-transposase	gnl|CDD|372577	pfam13359, DDE_Tnp_4, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	3.93626e-15
NC_017586.1|WP_086010087.1|2663572_2664765_-|IS3-family-transposase	gnl|CDD|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	2.45587e-96
NC_017586.1|WP_014143268.1|2658531_2659074_-|DUF3291-domain-containing-protein	gnl|CDD|378694	pfam11695, DUF3291, Domain of unknown function (DUF3291). This bacterial family of proteins has no known function.	1.48753e-31
NC_017586.1|WP_014143285.1|2672520_2672952_-|transcriptional-repressor	gnl|CDD|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	1.7125e-34
NC_017586.1|WP_014143264.1|2655823_2656249_+|LysR-family-transcriptional-regulator	gnl|CDD|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	9.84688e-21
NC_017586.1|WP_014143288.1|2673814_2674177_+|hypothetical-protein	gnl|CDD|224955	COG2044, COG2044, Predicted peroxiredoxins [General function prediction only].	7.60878e-17
NC_017586.1|WP_014143284.1|2671499_2672468_-|folate-binding-protein-YgfZ	gnl|CDD|223431	COG0354, COG0354, Predicted aminomethyltransferase related to GcvT [General function prediction only].	1.78724e-52
NC_017586.1|WP_014143266.1|2657091_2657997_+|LysR-family-transcriptional-regulator	gnl|CDD|182137	PRK09906, PRK09906, DNA-binding transcriptional regulator HcaR; Provisional.	1.65441e-36
NC_017586.1|WP_014143281.1|2669252_2670221_-|asparaginase	gnl|CDD|377601	pfam06089, Asparaginase_II, L-asparaginase II. This family consists of several bacterial L-asparaginase II proteins. L-asparaginase (EC:3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartate and ammonium. Rhizobium etli possesses two asparaginases: asparaginase I, which is thermostable and constitutive, and asparaginase II, which is thermolabile, induced by asparagine and repressed by the carbon source.	5.84601e-144
NC_017586.1|WP_014143274.1|2661356_2662859_-|WXG100-family-type-VII-secretion-target	gnl|CDD|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	0.0036914
NC_017586.1|WP_014143279.1|2666581_2667391_-|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.19046e-08

Protein sequences

>NC_017586.1|WP_014627918.1|2665045_2665423_-|hypothetical-protein
MTMPPERVRAAALLTDLGSHDPRLSLSVLDVARLTPLAARWLASGLPDTALHTALTASLPPLIHSPAALLTHRLRTEPPLPPQPPRPHHPSGPLPECTSCRDPLPRNSSAHHCHRCASVPVPLAT
>NC_017586.1|WP_086010087.1|2663572_2664765_-|IS3-family-transposase
MPAPRKYPDELRERAVREVRSTGRPVTHVARDLGIHKEALRSWVRQAEADAGERDDRLTSSELEELKQLRKENAELRRANEILKAASVFFCPGDRPSPDEAEQVIDHLRDKGLGVDPVCRVLGLSPSTYFARKTRPKSARRLRDEELIPLVTAAWEDSGRTYGARRVTRALVRAGHAVARCTVERLMRELGIEGVIRGQRRRTTVPEPTAPRPPDLVNRRFTAERPNQLWLADLTYIRTWSGWVYVAFVLDAYSRRIVGWQAATHMRTDLPLDALEMALWRQQIKKDAGLIHHSDRGSQYVSIRYTERLAEAGASASVGSVADSYDNAMAEALNGTFKAELIEHQGPWRDFDEVERAVFQWVAWYNGERLHSALGYLPPDEYEQAYWARPEQVPQTA
>NC_017586.1|WP_014143274.1|2661356_2662859_-|WXG100-family-type-VII-secretion-target
MVDLNPLHWINKINESIGHSMADVLEFIGITNPAVDPDGIREVARHWKALGDALDDAHWHVGQALGDLRWEGRAADAFHARAVEVRDQCEKTAKACHDGHDQLNRFADQAHELISEIGKLCAEILEFELAALPLSLLTGPLAEVASNLAAGERAVKITALIARIAEAARTVDRAAEAVLESLGTLGRALKALTPIAKMAAGGAATTLGYDAIVNPDRLRHADTLEQDVEIGALLGIIGGGFGKGIQGMLKGLGPRMVPALSDAGLLGELGGEDVAISRLGALMREENLPPEPGSEPPLTPEPVPPENPPDLLAEYESRSDPDALEKYDRIRAMTDDVERIAENCGIAPEIVTRAKENLFLKKHDVQFGPGKTVRNVYFNAYDELASVWLKARNWNVRPNTIGMVRGLIAHEYVEGRLMEAGVPYSSDDPSRWVAQPVNSRGNVGAHELSPLSLNGWPVTLEGTLKHWKLLGIEPPSAPVTDDLSNLDVVVDSILKWWKSA
>NC_017586.1|WP_106433172.1|2660826_2661216_-|hypothetical-protein
MGGADRWPFFDIAGRVAPAVRADPDQADRLERYLEENVGGFSTENACRWALRWATLRDVQGDHLPRLADPFEPLILMYERGGEIVPDETRSFNFGTRVVRALTWQEHLSPDPIVSLDPATLDALDAEES
>NC_017586.1|WP_041824660.1|2659345_2659879_-|hypothetical-protein
MGGKLAEAMLERLFVIDWRDSKNSIQHNVSRAKLMREYLRRAALWVNELGGTDRWPFFDIAGRIAPSVRTNPDLAARLERYIEENVGGISTEDALRAILRWATLRDVHKGQLPYPNDPFEPLLVMYERGGEVVADEARFFNFGHRSVRLKPWPQHLSPDPVVSLDPATLDALDREES
>NC_017586.1|WP_014143268.1|2658531_2659074_-|DUF3291-domain-containing-protein
MPHLALYTFSVLKSPLADPAPLTDEFYDIGEAVYREIGQRSGYLAHAEAADAERGVLFGADWGAWGEFTVPTWYGKGRTRETTALAATLSLWTGLRPAFDAIYTGLHRAALNRRYDWFERTGHPNYVAWWVSDDAIPTWRDGVSRLQHLHDHDPAPHAFTFHHAFAPDATPARLKGNGYA
>NC_017586.1|WP_014143267.1|2658057_2658339_+|hypothetical-protein
MNAALPDGWTIERVRSVSGDREAAVLSLDRLVVVEDYVRADRTPLQPDVILSFHNLCLVRDEGDWFIGHLGDDGSVICWASYGSGLEEAIRGL
>NC_017586.1|WP_014143266.1|2657091_2657997_+|LysR-family-transcriptional-regulator
METRELRYFVAVAEELHFGRAALRLGIAQPPLSRAISRLERRLGVTLLERTSRAVALTEAGAVLLAEARAALDAVEAAERRTRRAAHPTNGVVLATKAGASGDLLAELLDVYAAEPDAVTVDLLLCGIGEQERMLRDGRADVALLHLPYDGTAGFDTEELRVERQVVVLPAGHPLTGRDHVRMAEVTDLPGLPVPRWPGRDGTYPDGPGPKARDHTQLFQLIALGRACWIAPESCRTQLREGLAALPVVDAPPVTTVLAWPPQSRSRGVAGLVRVGVREFRAGRGEFSQARGTTTARSGAR
>NC_017586.1|WP_014143265.1|2656267_2656993_-|SDR-family-oxidoreductase
MSEQTIALVTGANKGIGYEIAAGLGALGWRVGVGARDEERRGTAVAKLRAAGADAFGVPLDVTDDASVADAAALIEERAGHLDVLVNNAAITGGSAQMPTTAGPAVVRAAVETNVIGVIRVTNAMLPLLRRSPSPRIVNMSSGVGSLTRQSTPGAETGPIAVAYAPSKTFLNAVTVQYAKELRGTGILINAACPGYCATDLNGFRGVRTPEQGAAIGIRLATLPDDGPTGGFFDDEGEVPW
>NC_017586.1|WP_014143264.1|2655823_2656249_+|LysR-family-transcriptional-regulator
MLSAERFMALVPAAHPLAGRAELSASELSATGLLTWPHQINSGLCDRLLAAFHIGGADLRIIRTADSVHAIAAHVAAGTGVGITVGSALDQQPPGLRVIPITGPSTTVDQVVLTPAEPSRTAVALRDLLLEASAEASSTGR
>NC_017586.1|WP_014143279.1|2666581_2667391_-|helix-turn-helix-domain-containing-protein
MINNQGSSNLRMFGSCVRYLRLRAGLSLEQLGALTNYSKSLVAAIETGDRMPSEAFILKAGKVFGAEDLLMEMAQHLSRETYPKWFLEFLELEKKARALHTYENHVIPGLLQTEEYMRAVFSAHCPALDDKQIEERVAGRLARHVIFDRRPAPVLSFVLEMATILRPIGGLAVQRAQLKRLLEVSEQRNVEIQLMRLERDTHAGLNGPFVLLETDDRRNLAYVEGQHGSRVFEDPEIVSDLTARYGIIRAQASSPEESRRLIEQVAKEL
>NC_017586.1|WP_014626964.1|2667473_2668244_+|IS5/IS1182-family-transposase
MSGVITASEPSWIAPFTGLSPRQFGKLITALRREGVDPVRKGRPWSLPLEDRVLLIAAYWRTNLTLRQLAPLFGVSKSAADRIIDHLGPALALQQRKRFRKDTVLIVDGTLVPTRDHTIAEQSKNYRYSTNHQVVIDADTRLVVAVGRPVAGNRNDCKAWELSGAKDAVGKTTVIADGGYRGTGLVIPHRREKGQTELPEWKEEHNASHRKVRARVEHVFARMKGWKILRDCRLKGDGVQHAMLGIARLHNLVLAG
>NC_017586.1|WP_014143280.1|2668360_2669029_-|hypothetical-protein
MTTRRARRTVRSAGLLAIAAAAAFSLTACGPNDPAGSSNAAGSGNASASTSTSGTGSTGSSAQGGTSGTHHSTTAGTASTNGGTTSPTRTQTLPDGSKAEIYRLGSQHYRAKIVNNGSVLATLETNQHDAGLDANDMFVVLTLDGQVHAWMGGGHQGPGTFDLAGGWKAKVTKVGELRYRAQIIGNDGSVDATLETDQHDVGLDANGAYVVLSNGGVISAHM
>NC_017586.1|WP_014143281.1|2669252_2670221_-|asparaginase
MTSVVPDQHAQLPVLAEVVRSGFTEGRHHGSLVVLDADGKVELALGDVTSPVFPRSSNKPMQAEAVLRAGVDLDGELLALAAASHSGETFHLDGVRRLLAAAGLPESALRTPADLPLDATESETWLAAGGVRKPILMNCSGKHAAMLWACVRNGWPTESYLDQDHPLQRLVLDVVRERSGESVDHVGVDGCGAPLMAISLTGLARVFRSYVTADPGTPARRVADAMRAHPEYVAGTRRPDTWLMRELPGTLSKMGAEAVQAVALPDGRALAFKIDDGASRALGPVLARTLRTMGVDAPVLDRIADAPLLGGGVRVGEIRAAF
>NC_017586.1|WP_014143282.1|2670299_2670932_-|hypothetical-protein
MTTPQDPVNGTPDPGATVIGTGTAHTTGSAPTNLTDLTALALPRLRTLRRDAQQEEADLSYLRRLLQGRVDILRAELARRTDPPAGRPAPPPRRPVVLPAALPLLDRLPEILTDDPSAVRQSARHVTLGTPRGAEYRRLADRILDDVGLSDLSARTDTELRAGLARMEALEQDISRRRRGLQETVDGCSAEITRRYREGEARIDDLLSGA
>NC_017586.1|WP_014143283.1|2671058_2671484_+|D-tyrosyl-tRNA(Tyr)-deacylase
MRAVAQRVTEAAVTVDGETVGKITGPGLCVLVGVTHDDTPEKAAQLARKLWSLRILPDERSCSDIDAPLLVVSQFTLYGDARKGRRPTWNAAAPGPVAEPLVDEVVARLRELGATVETGRFGASMKVSLVNDGPFTVVLEI
>NC_017586.1|WP_014143284.1|2671499_2672468_-|folate-binding-protein-YgfZ
MTSSPLLSLPGAVPAESPDEGVAGHYGDPFREQRALADGTAFVDLSHRGVVTVTGEDRLAWLHLLLTQHVSELPAHQATEALVLSAHGHVEHALYLVDDGTTTWAHVEPGTQGDLLAYLESMKFFYRVETADAGDAYAVVHLPAGNITEVPADWAVRETPWGRDVFVPRAELEAFAGRAGTPAGVLAHEALRIEAHRPRLGLETDHRTIPHEVGWLESAVHLNKGCYRGQETVARVHNLGRPPRRLVFLHLDGSEVKLPGHGAPVRLAEDGPDGRQIGFVTSSARHHELGPIALALVKRNVPADAVLLADTVPANQEVVVAP
>NC_017586.1|WP_014143285.1|2672520_2672952_-|transcriptional-repressor
MVTTDWKKDLRERGYRLTPQRQLVLEAVDTLEHATPDDILTEVRRTASGVNISTVYRTLELLEELGLVSHAHLGHGAPTYHLADRHHHMHLVCRDCGSVIEADVSVAQPLIDGLRQQFGFDTDMKHFAIFGRCADCAGSAAGG
>NC_017586.1|WP_014143286.1|2673008_2673572_-|FABP-family-protein
MIEIPSDLHPDIAPLVFLLGDWAGAGVFDFPGAEKCNFGQEVTFRHDGRPFLEYTSHTWVLDGDGNKVRPLESESGFWRVDGDRKVEVVMTRDSGVIEIWYGELAENKPQIDLATDAVARIASADEYSGGKRLFGYVKGDLMWVGEKATPSVPLRPYMSAHLKKVVSPAEWIKDIKDLPDDGIAFFK
>NC_017586.1|WP_014143288.1|2673814_2674177_+|hypothetical-protein
MTKQLVIKVTAGADAPERCSQAFTVAAVAVASGVEVSLWLTGESSWFALPGRAAEFELPHAAPLPELIDAILTGGRVTLCTQCAARRDITEDDVVEGVRIAGAQVFVREIMGEGVQALVY

Crispr_ID: NC_017586_6

• CRISPR_ID: NC_017586_6
• CRISPR_location: 3299845-3299921
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_017586_6

Consensus_repeat	Method
GCGGGAGGTACTGGGTGGCCGCG	CRISPRCasFinder

spacers of NC_017586_6

>6.1|3299868|31|NC_017586|CRISPRCasFinder
GCGTCCTCGCCCTCGGGGGCCACGGAGGCGT

CRISPR arrays and Neighbor proteins around NC_017586_6

CRISPR arrays

The CRISPR arrays of NC_017586_6

>merge|NC_017586|6|3299845-3299921|CRISPRCasFinder
GCGGGAGGTACTGGGTGGCCGCGGCGTCCTCGCCCTCGGGGGCCACGGAGGCGTGCGGCAGGTACTGGGTGGCCGCG

>NC_017586|6|6|3299845-3299921|CRISPRCasFinder
GCGGGAGGTACTGGGTGGCCGCG	GCGTCCTCGCCCTCGGGGGCCACGGAGGCGT
GCGGCAGGTACTGGGTGGCCGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017586.1|WP_014143866.1|3295311_3296046_-|RNA-polymerase-sigma-factor-SigM	unknown	unknown	gnl|CDD|236604
NC_017586.1|WP_014143863.1|3292856_3293192_-|thioredoxin	unknown	unknown	gnl|CDD|200072
NC_017586.1|WP_014143865.1|3294436_3295315_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014143873.1|3307084_3307714_-|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NC_017586.1|WP_106433127.1|3311125_3312649_+|DUF2029-domain-containing-protein	unknown	unknown	gnl|CDD|227937
NC_017586.1|WP_014143869.1|3300212_3302633_-|membrane-protein	unknown	unknown	gnl|CDD|212096
NC_017586.1|WP_014143870.1|3302866_3304315_+|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl|CDD|131739
NC_017586.1|WP_014143877.1|3313908_3315027_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	unknown	unknown	gnl|CDD|225224
NC_017586.1|WP_014143878.1|3315146_3315464_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014143867.1|3296124_3297846_-|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270875
NC_017586.1|WP_014143862.1|3292146_3292764_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_017586.1|WP_014143876.1|3312820_3313852_-|alanine-racemase	unknown	unknown	gnl|CDD|376473
NC_017586.1|WP_078590746.1|3289590_3290682_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|224113
NC_017586.1|WP_014143872.1|3305948_3307031_-|inositol-3-phosphate-synthase	unknown	unknown	gnl|CDD|132491
NC_017586.1|WP_157894833.1|3291989_3292142_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014143864.1|3293241_3294222_-|thioredoxin-disulfide-reductase	unknown	unknown	gnl|CDD|273540
NC_017586.1|WP_041824753.1|3290678_3291815_+|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|275105
NC_017586.1|WP_014143874.1|3308117_3310985_+|penicillin-binding-protein	unknown	unknown	gnl|CDD|223815
NC_017586.1|WP_078590744.1|3288546_3289308_+|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl|CDD|234637
NC_017586.1|WP_014143871.1|3304414_3305755_-|MFS-transporter	unknown	unknown	gnl|CDD|340863

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017586.1|WP_014143866.1|3295311_3296046_-|RNA-polymerase-sigma-factor-SigM	gnl|CDD|236604	PRK09643, PRK09643, RNA polymerase sigma factor SigM; Reviewed.	1.404e-88
NC_017586.1|WP_014143863.1|3292856_3293192_-|thioredoxin	gnl|CDD|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	6.61919e-42
NC_017586.1|WP_014143876.1|3312820_3313852_-|alanine-racemase	gnl|CDD|376473	pfam01168, Ala_racemase_N, Alanine racemase, N-terminal domain.	5.13002e-10
NC_017586.1|WP_014143873.1|3307084_3307714_-|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.80079e-19
NC_017586.1|WP_106433127.1|3311125_3312649_+|DUF2029-domain-containing-protein	gnl|CDD|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	1.33315e-30
NC_017586.1|WP_014143869.1|3300212_3302633_-|membrane-protein	gnl|CDD|212096	cd01022, GH57N_like, N-terminal catalytic domain of heat stable retaining glycoside hydrolase family 57. Glycoside hydrolase family 57(GH57) is a chiefly prokaryotic family with the majority of thermostable enzymes coming from extremophiles (many of these are archaeal hyperthermophiles), which exhibit the enzyme specificities of alpha-amylase (EC 3.2.1.1), 4-alpha-glucanotransferase (EC 2.4.1.25), amylopullulanase (EC 3.2.1.1/41), and alpha-galactosidase (EC 3.2.1.22). This family also includes many hypothetical proteins with uncharacterized activity and specificity. GH57s cleave alpha-glycosidic bonds by employing a retaining mechanism, which involves a glycosyl-enzyme intermediate, allowing transglycosylation.	0.00887309
NC_017586.1|WP_014143870.1|3302866_3304315_+|CCA-tRNA-nucleotidyltransferase	gnl|CDD|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0
NC_017586.1|WP_014143877.1|3313908_3315027_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	gnl|CDD|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	1.06252e-38
NC_017586.1|WP_014143867.1|3296124_3297846_-|serine/threonine-protein-kinase	gnl|CDD|270875	cd13973, PK_MviN-like, Pseudokinase domain of the peptidoglycan biosynthetic protein MviN. The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This family is composed of the mycobacterial protein MviN and similar proteins. MviN is an integral membrane protein that is essential for growth and is required for cell wall integrity and peptidogylcan (PG) biosynthesis. It comprises of 14 predicted transmembrane (TM) helices at the N-terminus, followed by an intracellular pseudokinase domain linked through a single TM helix to a carbohydrate binding extracellular domain. Phosphorylation of the MviN pseudokinase domain by the PG-sensitive serine/threonine protein kinase PknB recruits a forkhead associated (FHA) domain protein FhaA, which modulates local PG synthesis at cell poles and the septum. The MviN pseudokinase forms a canonical receptor kinase dimer.	1.39315e-57
NC_017586.1|WP_014143862.1|3292146_3292764_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.38211e-05
NC_017586.1|WP_078590746.1|3289590_3290682_+|AAA-family-ATPase	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	1.6652e-87
NC_017586.1|WP_014143872.1|3305948_3307031_-|inositol-3-phosphate-synthase	gnl|CDD|132491	TIGR03450, mycothiol_INO1, inositol 1-phosphate synthase, Actinobacterial type. This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.	0
NC_017586.1|WP_014143864.1|3293241_3294222_-|thioredoxin-disulfide-reductase	gnl|CDD|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	6.94133e-159
NC_017586.1|WP_041824753.1|3290678_3291815_+|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	3.15541e-76
NC_017586.1|WP_014143874.1|3308117_3310985_+|penicillin-binding-protein	gnl|CDD|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	1.4675e-139
NC_017586.1|WP_078590744.1|3288546_3289308_+|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl|CDD|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	1.39309e-75
NC_017586.1|WP_014143871.1|3304414_3305755_-|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.45164e-40

Protein sequences

>NC_017586.1|WP_014143867.1|3296124_3297846_-|serine/threonine-protein-kinase
MAERSTAAVDVANESGAPPLTAGAGGATVDGATAQSGAQDADRSDPEEGAEATPTTEPPELHSGHKLARRYRLEECLTQAAGFSSWRAVDEKLRRAVGVHVMPADSPRARNVLAAARSAALLGDPRFVQVLDAVEENDLVYVVHEWLPDATELTPLLAAGPMEPHEAYQLVSQLSQAMAVAHREGLAHLRLNPGAVLRTETGQYRIRGLAVAAALRGVESDRPKRTDTEAIGALLYAALTARWPYPDDAHGLTGLPKGLGLVAPDQVRAGVHRGLSDIAMRALVNDGATPSRQEKPVTTPEELAKAVAGLPKIRPPEPQAPPFPQVGYRQPPARPAQPQQARPVPAAPPPPALPGRTGTAVKWGVAALLIAALGLGSWQIADTLMNRDNGAPTTNSQNQKPTTHSGGGGTAAKRTGKPLPIVGALEYAPDGTFQDEGDARATYDGKPDTYWHSHSFDDGPELQPSVKKGVGLIYDLGSTQKVTGAEIGLKFGGDHTTVSLYASDEYSSAASMSSMRKLGTVQTSDNTAKFQLGQPAQARYLVIWLTAMPYFGQDNYSKPGYKQGITEVSFTGQ
>NC_017586.1|WP_014143866.1|3295311_3296046_-|RNA-polymerase-sigma-factor-SigM
MAWTVAAATLARENDVTRGNPTESADDAALLARHVAGEPDAFGELVRRHRDRLWAVALRTLGDPEEAADAVQDALVSAFRAAHTFRGQSAVTTWLHRITVNACLDRARKSAARRTAPVPDEERFDTLLEPHESAEAPAERDELHRELIRALGALPPDQRAALVLVDMQGYPVAEAAEVLGVPPGTVKSRCARGRARLLPLLTHLRSGRGDNGSPPGGRNRAEATSVPQTAAKDQDVVKGGGGQR
>NC_017586.1|WP_014143865.1|3294436_3295315_-|hypothetical-protein
MTSPPDTNGHPEVAEISALAEGILPPERSADLRGHLAVCVLCTEVRDSLDEIRGLLGTLPGPPRMPEEIAGRIDAALAAEALISATTPAPEAPATEPVSRETDGAAGAVSRETAATAGRRPEGHPTAATGPGRGRPRRRRARLALTGAAGAAVLAFGGLLTYSLTSGPAVTGTSRQAAAFSGTELPVRVHQLLAGTPGTGAGTAAPHTGVNTPFTAHVAPGVPGCVLKGTGRGEAPLASAGGSYQGHASYLVVFPHPGDGAKVDAYVVDASCVSSGSPGPGTVLTRQTYDRS
>NC_017586.1|WP_014143864.1|3293241_3294222_-|thioredoxin-disulfide-reductase
MSDVRNVIIIGSGPSGYTAALYTARASLKPLVFEGAVTAGGALMNTTEVENFPGFRDGIMGPDLMDNMRAQAERFGAELIPDDVVEVDLTGDIKLVTDSAGTVHRAKSVIVATGSGYRKLGLPNEDTFSGRGVSWCATCDGFFFKDQDIVVVGGGDTAMEEATFLSRFAKSVTIVHRRDTLRASKAMQERAFADPKISFIWDSEVSEIHGDGKLSGLTLRNVRTGATSKLPVTGLFIAIGHDPRTELFKGQLDLDEEGYLKVEAPSTRTNLAGVFAAGDVVDHTYRQAITAAGTGCSAALDAERYLAALSDRPEETAEPEKAAAAL
>NC_017586.1|WP_014143863.1|3292856_3293192_-|thioredoxin
MAGAIITVTDADFEEKVLNSDKPVLVDFWAEWCGPCRQVAPSLEAIAAEHDEILIAKLNIDQNPETTTKYGVMSIPTMNVYQGGEVAKTIVGAKPKAAIERDLADFLAAKG
>NC_017586.1|WP_014143862.1|3292146_3292764_+|GNAT-family-N-acetyltransferase
MGRRLVPLTLDNLPDLPKRCRSCVFWELDPVSGEAATQAGKPELEKEAWISAVLLEWGSCGRVVYVDDVPAGFVLYAPPAYVPRSTAFPTSPVSPDAVQLMTSRILPGFQGQGLGRVLVQTVAKDLVRRGFKAIEAFGDAHWEEPSCILPADHLTAVGFKTVRPHPRFPRLRLVLRSTLSWREDVEMAIDRLLGAVQKEPALRPL
>NC_017586.1|WP_157894833.1|3291989_3292142_+|hypothetical-protein
MKHEWRPAALVAAGLGLGAMGGFLVGLLRDRGTLKDAGFSKSCMVTKARA
>NC_017586.1|WP_041824753.1|3290678_3291815_+|ParB/RepB/Spo0J-family-partition-protein
MTERRRGLGRGLGALIPAAPTGAEPGPAVGAPVTSPSAVPVLTAERGVAAAKVAGLTESGVRTADPAPQIPVSRETEAPSPKKAEPEPALNEVVGAHFAEIPLDAIVPNPRQPRAYFDEDALDELVTSIKEVGLLQPVVVRETGPGSYELIMGERRWRACREAGLKRIPAIVRATEDEKLLLDALLENLHRAQLNPLEEAAAYDQLLKDFRCTHEELADRIGRSRSQVSNTLRLLKLSAPVQSKVAAGVLSAGHARALLGLDDVEAQDRLARRIVAEGLSVRSVEEIVNVMASAAKSAKRSKGPRAGKRLSPALSDLASRLSDRLDTRVKVDLGQRKGKIVVEFASIEDLERILGSIAPGEGKVLQKGLAAETEDPAS
>NC_017586.1|WP_078590746.1|3289590_3290682_+|AAA-family-ATPase
MAGSEHCEPPAEESESLRPDASTAGPMTDPVPGPRSETTAEDVSRETLPPMDDTPIGRAAQMAVEALGRAGEGLPRPEETRVIVVANQKGGVGKTTTTVNIAASLALHGGRVLVVDLDPQGNASTALGIDHHAEVPSIYDVLVESKPLSDVVQPVRDVEGLFCAPATIDLAGAEIELVSLVARESRLQRAIAAYEQPLDYILIDCPPSLGLLTVNALVAGAEVLIPIQCEYYALEGLGQLLRNVDLVRGHLNPKLHVSTILLTMYDGRTRLAAQVADEVRSHFGKEVLRTSIPRSVRISEAPSYGQTVLTYDPGSSGALSYLEAAREIALRGAGISVGYEAQEAHIARQNNEYGQHTMSEGIK
>NC_017586.1|WP_078590744.1|3288546_3289308_+|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MTASEGTVPVTEAAELPPAPEEARAVFGERFADAVRYAELLADAGVRRGLIGPREVPRLWARHLLNCAVLSDVVPKGVSVCDVGSGAGLPGIPLALARPDLRITLLEPLLRRTTFLQEVVDLLGLENVTVVRGRAEEMIGHLQPVDVVTARAVAPLDRLAGWGLPLLRPHGEMLALKGDTAEEELTHARAALDRLGAVDTSVVQAGVGLVDPPSTVVRVLVGESPGGVRAAARRARVARANRPVRSGGGRRRR
>NC_017586.1|WP_014143869.1|3300212_3302633_-|membrane-protein
MRDAAKHPGTTSLPACLPAGNTAARSGPAPRPPVRRGRLRRVAALLLGAALLALPAQLPGASRAQAAPSRTESAHGSAAAVSIDSLAPAVPGKSDTLQISGTVANTGDETITGGHVGVRVGGGGPLGSRSAITDTSSDDDFNPGADGPEVSGHTTKLADIPAGVSVPFTLSVPVSALGLGSDGVYQLGVTASGTTRDTGYDHVLGIERTFLPWYAQGGGQKTGTAFLWPLIDRPHLDIRPPGDNQQAPLFRDDDLASELAPGGRLDELVSLGKDLPVTWVVDPDLLASVDAMTKPYRVLGADGDPKRTTPGTGSDYAKRWLDELQTAVKGHEVVALPFGDPDIAAIAHHGKDVSGTIGHLKAATDLASVTVQTVLGVTPRTDFAWPAEGAVDPSIIGVATAAGADKVIARSDSLHETELNYTPTAARPIGGGTTAVVADAGLSKAFTGDMTRAGSVTSAVQRFLAQSLMITEQEPQRQRSIVVAPQRMPTTGQAQAMAAAIGALRSGTWVEPAGLGAAAAATPDPGANRSVPGGDSYPGALRGQELGTDAFQQIQSVQESLDGFEVILSRKDRVTTPFGNAVLRAMSTQWRGAGAQAAAFRNDVSAYLSDLRQDVRISDKDSITLSGRSAIIPVTVQNSLAQQVTGLELRLTSAQPNRLSVGKPQNVDIDGGHNRSLKFATTARANGKAWISAQLYTRDGAPYGEAMVFQVNVTSITDTVMLVIAGGLLLLVLAGVRMYRQRKRLAQRRAEEEGGGDAPATGDAPAPAPDDAAGDEPTRPEQPGDPAPDTAAGEAGPSEPGEKVDR
>NC_017586.1|WP_014143870.1|3302866_3304315_+|CCA-tRNA-nucleotidyltransferase
MAPAEASALNQVQRRAVGELLRVSPVADDLGRRFEQAGFRLALVGGSVRDALLGRLGNDLDFTTDARPEQVLKILRGWADAVWEVGIAFGTVGCRKADAAGNDFQIEVTTYRSEAYDRDSRKPEVSYGDTIEEDLVRRDFTVNAMAVSLPGIEFVDPHNGLEDLARRVLRTPGTPQESFSDDPLRMMRAARFAAQLDFDVAPEVVAAMTEMADRISIVSAERVRDELNKLVCGAYPRKGLQLLVDTGLADRVLPELPALRLERDEHHRHKDVYEHTLTVLEQAIALEESGPDPVLRLAALLHDIGKPKTRRFEPDGRVSFHHHEVVGAKLTKARMTKLKYPNDEVKAVSRLVELHLRFHGYGSGEWTDSAVRRYVRDAGPLLERLHKLTRSDCTTRNKKKAAALARTYDSLEARIAQLKEQEELDAIRPDLDGNEIMEILGVPAGPVVGKAYKHLLELRLENGPMAHDEAVAALKEWWAGQR
>NC_017586.1|WP_014143871.1|3304414_3305755_-|MFS-transporter
MAVIEDLRALLRFPDFRRLLAARLLSQLADGVYQVALAAYVVFSPEKQASPGAIAAAMAVLLLPYSLLGPFTGVLLDRWRRRQVLLHGNLLRSVLAAGTAVLVLVHVPDVFFYLSALSVTAVNRFVLAGLSAALPRVVDGDRLVVANSLCPTVGTIAATVGGAAAFAVHLVLRPGPGSDAAVVVLAAVIYLFAGLSARALDPDRLGPDPELLRPRLAGAVAGTVRGLVAGLRHLAARPQAARALAAMTVLRFAYGALFVTLLMLARNAWSPPGNASGGLALLGLAVGVSGAGFFAAAVITPWATTRCGTTGWITVCAAAAAVLEPCLGLPFEPAPMLVAAFLLGAATQGAKIATDTVLQAEVDDAFRGRVFALYDVTFNAAFVAAAALAALLLPPDGRSPALLLLVAAVYVAVAVTMARFVRQGARRAAPEAEPRQAEWEPEERAG
>NC_017586.1|WP_014143872.1|3305948_3307031_-|inositol-3-phosphate-synthase
MGSVRVAIVGVGNCAASLVQGVEYYKDADPDSRVPGLMHVQFGDYHVRDVEFVAAFDVDAKKVGLDLADAIGASENNTIKICDVPPSGVTVQRGHTLDGLGRYYRETIEESAEEPVDVVQILKDRQVDVLVCYLPVGSEEAAKFYAQCAIDAKVAFVNALPVFIAGTKEWADKFTEAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVVLDRTMQLNVGGNMDFKNMLERDRLESKKISKTQAVTSQIPDRDLGAKNVHIGPSDYVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDALRAAKIAKDRGIGGPVLSASSYFMKSPPVQYFDDEARENVEKFIRGEVER
>NC_017586.1|WP_014143873.1|3307084_3307714_-|PadR-family-transcriptional-regulator
MSRRSGVLEFAVLGLLRESPMHGYELRKRLNTSLGVFRAFSYGTLYPCLKALVSQGWLVEEPPADEPGTAAPLAGRRAKIVYRLTAAGKEHFENLLAQTGPEAWEDEQFGVRFAFFGHTERDVRMRVLEGRRSRLEERLEKMRASLARTRERLDDYTLELQRHGMESVEREVRWLNELIETERAGRDRAKGRPADDQGRDDTDPTDTTN
>NC_017586.1|WP_014143874.1|3308117_3310985_+|penicillin-binding-protein
MSEHRRKPPQPNGSGRAADRRGAPPPGNGHRGAPPGRGADGYGTGAPSGPDRSYGSAPSPGSGPSYGGGSPYGSAPGGEGRAARRRAAGSEAGTASEGVPERPYGGRAEARRAAKGGRRAAGGAGSRGGGGRRGTGGGGSGPGGQGPGGQRPKRFIDYPRWGKTGWRRWMPSWKQVSAICVAFLGTLVGLVGIAYAMVDVPNPNAAAKQQKNVYYWADGSRMVVAGGGDYNRQIVPLDKISIHMQNAVISMENASFYHDAGVDPQGILRAILRMAQGGETQSGSTITQQYVKNTYLDQSQTLTRKFKELLISVKVGATVDKKDILAGYLNTAFYGRGAYGIQAASQAYYGVDADKLKPDQAAFLAAVLNGPNLYDPAGGIGDGATPEENTKRAVQRWNEVLDREVKTGDMTQQERAKYTKFPMPQKPKRSTDKAGQIGYLTDLANKYILNNTNISQHNLDNGGYQIHTTFDKNKVRALQQAVDSVRKKNLKPDVRSADKYVQFGGASVVPGDGAIVAIYGGEDYLKHFTDNADYTGAQVGSTFKPFVLAAAMQDGVRNPSLGPDQGPSERTKVSLKSMYTGLNKWKVLNYNRTVWQDPDGKEWLQVNDDNESIPTVDLKTAMAQSLNSTYAQLGMDVGMDKVRQAAITAGLQDDQSMVSTNGPSFSLGVSSPSAIRMADAYGTFAHGGVQADPYSVTRVEYQGTVKYQHETKTKQAFDPAIAGNVTDALQAVVQEGTGTAAKALGRPAAGKTGTTDDNKSAWFTGYTPELATSIGMYRMDDHATNPTFLKMYGVGGLDKIYGASFPTQIWTEYMKDALAGKPVQDFPPASAYGTVVHGPGATESAPPSAPPSNSPSVTPSAPPSKSPSHSPSPSITPTPTHSSCGLFGCEPGGTTTGTGSNNGNENGGPGSNTGTTNGAGNAGTTSGTGSSRGNGNGGPGGNGNGNGNGGGGIFG
>NC_017586.1|WP_106433127.1|3311125_3312649_+|DUF2029-domain-containing-protein
MSAMTTARKNAESAAAAPSTPPTWDDPVARAGSELLGGPAGRRMGAVAGRWWNPLRVIVLAAVGLFALGMVQKLPCYDSGWFFGANDQYTHACYSDIPHLFYARGFADDVVPYFGHIPDKVSGGMPYLEYPVLTGLFMEIASWFTPHGADLIRREQIYWLVNSGMLLVCAVVTVVAVARTHRRRPWDGLLVALAPAAALTATVNWDLLALALTAVGMLLWARRRPVASGVLIGLATAAKLYPALLLGPLLLLCLRAGRMRAFTKALAGAVVAWLVVNVPVMLAHDATGFHIRPGWAQFYSYSQTRPVDFGSLWLLISQQTGNPLPDANTYAIVLMLLLCAGLAWLVLYAPRRPRFAQTAFLVVAAFVLTNKVYSPQYVLWLVPLAALARPRWRDFLVWQAGEVMYFLGIWMYLAFTTGGNNKGLPEGGYDLAIALHLLATGYLCACVVRDILRAEHDPVRQDGSDDPSGGVLDGAPDVFVLGTAGARHAARSSGTAVRWGTPPDQAA
>NC_017586.1|WP_014143876.1|3312820_3313852_-|alanine-racemase
MALTLYVDTARWRAHHKTVVDQFPGIIPVCKGNGYGFGHERLAEETARLGADMIAVGTTYEAARMKDLFGGDLLVLTPYRLGEEPVPLPDRAIRSVSSVEGVRGLVGARVIVEVMSSMRRHGVLPEELGRLRGAIEDVRLEGFAIHLPLDRTDGSDGVQEVHGWMERLRAAGLPLHTMFVSHLKADELVHLQRQFPQTRFRTRIGTRLWLGDHQATEYRGAVLDVTRVGKGERYGYRQQKAAGEGHLVVVAGGTSHGVGLESPKAVHGVMPRAKGVARAGLATVNRNLSPFVWAGKQRWFAEPPHMQVSILFLPGDVAPPQMGEELVAHLRHTTTQPDRMVDR
>NC_017586.1|WP_014143877.1|3313908_3315027_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein
MSLTLRTISREQHLAYIQSLPSASHMQVPAWADVKAEWRSENLGWFDKNGELVGVGLVLYRQLPKIKRYLAYLPEGPVINWYAPNLEEWLQPMLAHLKRQGAFSVKMGPPVVIRRWDAAAVKNGIADPDAKRLRDVEATFIEPRAFEVADRLRKMGWQQGEDGGAGFGDVQPRYVFQVPLEGRTLEDVHKGFNQLWRRNIKKAEKAGVEVVQGTYEQLPIWQQLYEITAERDHFRPRPLSYFQRMWTALNSEDPNRMRLYFAVHEGEAVAAATMLVVGGHVWYSYGASANHKREVRPSNAMQWRMLRDAYALGATVYDLRGISDSLDENDHLFGLIQFKVGTGGQAAEYLGEWDFPLNKLLHKALDIYMSRR
>NC_017586.1|WP_014143878.1|3315146_3315464_-|hypothetical-protein
MAQTFRQFRQRHVLTLNTDGRPHPVENTLTVITVVLGAVAALTSLSRGLHLVSSWTGLLGIVSGAYGQYISATTAERFLLVIGLGAAAVGFFIGMAHGGLFGGVV

Crispr_ID: NC_017586_7

• CRISPR_ID: NC_017586_7
• CRISPR_location: 4716726-4716824
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_017586_7

Consensus_repeat	Method
GCCGGTCGGCCGGGTGCGGCCGGGA	CRISPRCasFinder

spacers of NC_017586_7

>7.1|4716751|49|NC_017586|CRISPRCasFinder
AACGCCGCCGCGTGGGGGGGGCGGCTGTGCCGCGTCGGTGGCGGGCGCT

CRISPR arrays and Neighbor proteins around NC_017586_7

CRISPR arrays

The CRISPR arrays of NC_017586_7

>merge|NC_017586|7|4716726-4716824|CRISPRCasFinder
GCCGGTCGGCCGGGTGCGGCCGGGAAACGCCGCCGCGTGGGGGGGGCGGCTGTGCCGCGTCGGTGGCGGGCGCTTGCCGTCGGCCGGGTGCGGCCGGGA

>NC_017586|7|7|4716726-4716824|CRISPRCasFinder
GCCGGTCGGCCGGGTGCGGCCGGGA	AACGCCGCCGCGTGGGGGGGGCGGCTGTGCCGCGTCGGTGGCGGGCGCT
TGCCGTCGGCCGGGTGCGGCCGGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017586.1|WP_014145106.1|4710510_4711668_+|D-alanine--D-alanine-ligase	unknown	unknown	gnl|CDD|234993
NC_017586.1|WP_014145116.1|4720720_4721233_+|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl|CDD|234674
NC_017586.1|WP_014145110.1|4713712_4714501_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl|CDD|180561
NC_017586.1|WP_041824911.1|4723303_4723477_+|50S-ribosomal-protein-L32	unknown	unknown	gnl|CDD|237038
NC_017586.1|WP_014145120.1|4724379_4725258_+|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	unknown	unknown	gnl|CDD|234899
NC_017586.1|WP_014145115.1|4720142_4720724_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl|CDD|367574
NC_017586.1|WP_014145107.1|4711701_4712196_-|DUF3515-domain-containing-protein	unknown	unknown	gnl|CDD|378794
NC_017586.1|WP_014145104.1|4708722_4709478_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NC_017586.1|WP_014145112.1|4715049_4716690_+|DAK2-domain-containing-protein	unknown	unknown	gnl|CDD|274671
NC_017586.1|WP_014145108.1|4712216_4712450_-|Lrp/AsnC-ligand-binding-domain-containing-protein	unknown	unknown	gnl|CDD|366431
NC_017586.1|WP_014145113.1|4717215_4719423_+|ATP-dependent-DNA-helicase-RecG	unknown	unknown	gnl|CDD|236794
NC_017586.1|WP_014628431.1|4714614_4714800_-|50S-ribosomal-protein-L28	unknown	unknown	gnl|CDD|234736
NC_017586.1|WP_014145117.1|4721363_4722497_+|hypothetical-protein	unknown	unknown	gnl|CDD|349951
NC_017586.1|WP_014145118.1|4722641_4723301_+|DUF177-domain-containing-protein	unknown	unknown	gnl|CDD|376863
NC_017586.1|WP_014145121.1|4725268_4725679_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224647
NC_017586.1|WP_014145114.1|4719554_4720073_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014145119.1|4723496_4724285_+|ribonuclease-III	unknown	unknown	gnl|CDD|234633
NC_017586.1|WP_014145109.1|4712668_4713634_+|thiamine-phosphate-kinase	unknown	unknown	gnl|CDD|235583
NC_017586.1|WP_014145105.1|4709474_4710476_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|234629
NC_017586.1|WP_106433144.1|4707840_4708503_-|2-phospho-L-lactate-guanylyltransferase	unknown	unknown	gnl|CDD|274643

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017586.1|WP_014145106.1|4710510_4711668_+|D-alanine--D-alanine-ligase	gnl|CDD|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	0
NC_017586.1|WP_014145116.1|4720720_4721233_+|pantetheine-phosphate-adenylyltransferase	gnl|CDD|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	1.23701e-98
NC_017586.1|WP_014145110.1|4713712_4714501_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl|CDD|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	1.84589e-125
NC_017586.1|WP_041824911.1|4723303_4723477_+|50S-ribosomal-protein-L32	gnl|CDD|237038	PRK12286, rpmF, 50S ribosomal protein L32; Reviewed.	8.0342e-25
NC_017586.1|WP_014145120.1|4724379_4725258_+|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	gnl|CDD|234899	PRK01103, PRK01103, bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase.	8.82117e-149
NC_017586.1|WP_014145115.1|4720142_4720724_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl|CDD|367574	pfam03602, Cons_hypoth95, Conserved hypothetical protein 95.	5.9465e-66
NC_017586.1|WP_014145107.1|4711701_4712196_-|DUF3515-domain-containing-protein	gnl|CDD|378794	pfam12028, DUF3515, Protein of unknown function (DUF3515). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 166 to 214 amino acids in length. This protein has a conserved RCG sequence motif.	1.33123e-13
NC_017586.1|WP_014145104.1|4708722_4709478_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	2.77951e-40
NC_017586.1|WP_014145112.1|4715049_4716690_+|DAK2-domain-containing-protein	gnl|CDD|274671	TIGR03599, YloV, DAK2 domain fusion protein YloV. This model describes a protein family that contains an N-terminal DAK2 domain (pfam02734), so named because of similarity to the dihydroxyacetone kinase family family. The GTP-binding protein CgtA (a member of the obg family) is a bacterial GTPase associated with ribosome biogenesis, and it has a characteristic extension (TIGR03595) in certain lineages. This protein family described here was found, by the method of partial phylognetic profiling, to have a phylogenetic distribution strongly correlated to that of TIGR03595. This correlation implies some form of functional coupling.	2.6409e-141
NC_017586.1|WP_014145108.1|4712216_4712450_-|Lrp/AsnC-ligand-binding-domain-containing-protein	gnl|CDD|366431	pfam01037, AsnC_trans_reg, Lrp/AsnC ligand binding domain. The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold.	2.65137e-07
NC_017586.1|WP_014145113.1|4717215_4719423_+|ATP-dependent-DNA-helicase-RecG	gnl|CDD|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NC_017586.1|WP_014628431.1|4714614_4714800_-|50S-ribosomal-protein-L28	gnl|CDD|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	4.67457e-24
NC_017586.1|WP_014145117.1|4721363_4722497_+|hypothetical-protein	gnl|CDD|349951	cd06503, ATP-synt_Fo_b, F-type ATP synthase, membrane subunit b. Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.	1.67923e-06
NC_017586.1|WP_014145118.1|4722641_4723301_+|DUF177-domain-containing-protein	gnl|CDD|376863	pfam02620, DUF177, Uncharacterized ACR, COG1399. This family is nearly universally conserved in bacteria and plants except the Chlorophyceae algae. Thus far, mutantional analysis in bacteria have not established a function. In contrast, mutants have embryo lethal phenotypes in maize and Arabidopsis. In maize, the mutant embryos arrest at an early transition stage.It has been suggested that family members specifically affect 23S rRNA accumulation in plastids as well as bacteria.	1.94378e-27
NC_017586.1|WP_014145121.1|4725268_4725679_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	4.77821e-35
NC_017586.1|WP_014145119.1|4723496_4724285_+|ribonuclease-III	gnl|CDD|234633	PRK00102, rnc, ribonuclease III; Reviewed.	4.65481e-120
NC_017586.1|WP_014145109.1|4712668_4713634_+|thiamine-phosphate-kinase	gnl|CDD|235583	PRK05731, PRK05731, thiamine monophosphate kinase; Provisional.	1.19831e-127
NC_017586.1|WP_014145105.1|4709474_4710476_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	gnl|CDD|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	9.9947e-180
NC_017586.1|WP_106433144.1|4707840_4708503_-|2-phospho-L-lactate-guanylyltransferase	gnl|CDD|274643	TIGR03552, F420_cofC, 2-phospho-L-lactate guanylyltransferase. Members of this protein family are the CofC enzyme of coenzyme F420 biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	4.89474e-42

Protein sequences

>NC_017586.1|WP_014145112.1|4715049_4716690_+|DAK2-domain-containing-protein
MPPTLDAVAVRTWCRLALAELGRAREEIDAINVYPVADGDTGTNLYLTVESAAQSVDAVFDGHASSGARPDRAQTVRAMAHGALIGARGNSGTILAQLLRGMSEILAAPQPPRPDDADTLRRALRHAAASAHQAVAHPAEGTMLTVAAAAADAACATAGDVAAAARAAYDAACAALARTPGQLAALGRAGVVDAGGRGLVAVLGALARAVGATAQAPPATTARPLPDPRHDCAAGRDPHLAQDGPAFEVVYLLEAADSAVPALRARLDALGDCLVVVGGDGLWNVHVHVDDAGAAVEAGVDAGRPYRIRITHFGDQCRTGRRTAALEQRAVVAVADGDGLAALYAGAGATVVPVPAGEPLASGDLAAAVRRAHAREVVLLPNDAELLHLAGVAAEQARADGLRVALIPTRSAVQGIAALAVHQPSRRFDEDVVAMTAAAGATRYAAVAVAERESWTMAGVCQAGDLLGLIDGDVVVIGDDLARTAVTVLDRMLAAGGEMVTLVPGAGAPPGLADHLTDHVREHHLAVDTVVHPGGQHTCPLVIGVE
>NC_017586.1|WP_014628431.1|4714614_4714800_-|50S-ribosomal-protein-L28
MAANCDVCGKGPGFGNNISHSHRRTRRRWNPNIQTVRAVVGRTPKRLNVCTSCIKAGKVAR
>NC_017586.1|WP_014145110.1|4713712_4714501_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MRIPPRVLTVAGSDSGGGAGIQADLKTMLALGTHGMSVVTAVTAQNSLGVQGAWELPAEAVRAQFRSIVDDIGVQAVKTGMLASPELVRTVARLLAGVDAPVVVDPVGVSKHGDRLLAAEALESVRERLLPTATVATPNLDEVAELTGVKVTDEDGMREAARAILAYGPRWALIKGGHLPGAPVDLLSDGREEHWFRGARHDNRHTHGTGCTLASAIAAHLAKGLDVPQAVGAAKAYVTGAIAAGFPLGAGIGPVDHAWQWG
>NC_017586.1|WP_014145109.1|4712668_4713634_+|thiamine-phosphate-kinase
MKGTVGELGEFGLIRELTSRLTTTPAVRLGPGDDAAVVAAPDRRVVASTDVLLEGRHFRRDWSTAYDVGRKAAAQNLADIAAMGATPTALLLGLVVPAELPATWPLELMDGISDECQVAGAAVAGGDVVRGDAITVAITALGDLQGRRPVTRSGARPGDVVAVTGWLGWSAAGYALLSRGFRSPRAFVEAHRRPEPPYAEGPAAAALGATAMTDVSDGLLADLGHIAEASGVSIDVKRAALDVPAQMTDIGQAVGVDPVDWVLTGGEDHAIVAAFPAKAKLPARWRVIGEVLGAGAGPQVTVDGAVWEAAGGWDHFGAPAG
>NC_017586.1|WP_014145108.1|4712216_4712450_-|Lrp/AsnC-ligand-binding-domain-containing-protein
MVQAYILIQTEVGKATVVAEVISKLPGVLTAEDVTGPYDVIVRAQADTVDELGRMVVAKVQQVDGITRTLTCPVVHL
>NC_017586.1|WP_014145107.1|4711701_4712196_-|DUF3515-domain-containing-protein
MNVFVPARLRPLLPLPATVLLTVAGCSSGPANAVAVPSPSPSAAAICRALHDRLPGTVDGLARHATTPASPFTAAWGNPQVELRCGVPRPRSLTPGDPHYDPTAEAVGVNDVTWLPQQFDGGYRFTTTGRAAFVEVTVPSAYKPEVNPLTDLAAAVKRADPTEL
>NC_017586.1|WP_014145106.1|4710510_4711668_+|D-alanine--D-alanine-ligase
MSNMPSHHSRPPSGRKPRVAVVFGGRSSEHAISVVTAGAVLRAIDRTKYDVLPIGITTDGRWALAADEPDRMAITAGQLPDVARLAESAEGSVVLPVDPASREVVLSEPGSVPKALGEVDVVFPVLHGPYGEDGTLQGLLELSGVPYVGAGVLASAVGMDKEYMKRVFTSFGLAVGPYLVIRPREWHADPAAARRRITDFAEREGWPLFVKPARAGSSMGISKVDGPDELDAAVELAQSHDPKILVESALSGREIECGVLEFEDGPRASVPAWIPPADAHGFYDFEAKYIDSAEGVVPAPLTDEETARVRELAVRAFDAVSCEGLVRADFFLTDDGEFVINEVNTMPGFTPISMYPRMWEATGVDYPELVDRLIQAALRRSTGLR
>NC_017586.1|WP_014145105.1|4709474_4710476_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase
MTRCAVYGTGSWGTAFAMILADAGCEVTMWGRRPALAETINTTRINPDYLPGVALPPSVTATTDPARAAEGAEFVVLAVPSQTLRENLAAWAPLFPADAVLVSLMKGVELGTKKRMSEVIEEVAKAAPERVAVLSGPNLAGEIAARQPAAAVVACRDEEVARRLQSACHTAYFRPYTNTDVVGTELGGAVKNVIALAVGIAEGMGLGDNAKASLITRGLAETTRLGLAMGADAHTFAGLAGMGDLVATCASPLSRNHTFGINLGRGMTLEETVAVTKQTAEGVKSCRSVLDLARDMGVEMPITETVVGIVHQGKPPLVALKELMSRSTKAERR
>NC_017586.1|WP_014145104.1|4708722_4709478_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MSRRRIGFWYRLAAVIVKPWLIVLFKRDWRGMENIPADGGFITAINHNSYLDTFSYAHFQYNTGRVPRFLAKDALFRKGVAGAFMRGTDQIPVYRESVNAAGAFRAAVAAIERGECVAFYPEGTLTRDPGLWPMTGKTGVARVALLTRAPVIPIAQWGANEALPPYGKPRLLPRKTLRVVAGPPVDLSAYYDQEPTPEVLRAATGTIMDAITGLLEELRGERAPAERYDMRKAREEERRRADRAAEREESK
>NC_017586.1|WP_106433144.1|4707840_4708503_-|2-phospho-L-lactate-guanylyltransferase
MWDLVVPLKPLTVAKSRLRGAAAAGVVVRPPLALAFAQDTVAAALACPAVAGVTVVTDDPLAAPELAALGARVFPDAPGGGLNAALTHGARLVRAERPGASVAALNADLPALRPAELARALSVAGRARRAFVADAAGLGTTLLTASRGTDLSPAFEGPSRARHLASGAREIRLPDIDSLRRDVDTPADLRIALSLGVGPHTTTATTGIFAKGGAFAEHPE
>NC_017586.1|WP_014145113.1|4717215_4719423_+|ATP-dependent-DNA-helicase-RecG
MAALDEPLRKVVGDRTAKVLADHLDLHTTGDLLHHYPRRYAERGELTRLADLPLDEHVTVVAQVAKAEKKTYNRGAGVRLEVVVTDGSGSLQLVFFNKAAHFHHTKLVPGRRGMFAGKVTVFNRVRQLAHPDYQLLDAEDGEEAVDAFAGRLLPLYPACKQIASWQIAQAVDVVLDSLTGTEWAGVADPLPARLRADRGLAPLPEALLKVHRPATRADIADARERLKWDEAFVLQVALARRRADDAARPAVARRPKDDGLLTAFDARLPFTLTEGQTKVSAEIFADLAAEHPMHRLLQGEVGSGKTLVALRAMLAVVDSGGQAAMLAPTEVLAQQHHRSITEMMGDLAEGGMLGGADVGTKVVLLTGSMGAAARRQALLDLVSGDAGIVVGTHALIEDKVTFHDLGLVVVDEQHRFGVEQRDALRGKGNRPPHLLVMTATPIPRTVAMTVFGDLETSVLDQLPAGRSPIATHVVPAKDKPHFLTRAWERVREEVAAGHQGYVVCPRIGDEEEPAKAKETKEGKEAADDAERRPPLAVLDVAEQLATGPLAGLRVEVLHGRMQPEAKDDVMRRFAAGQVDVLVATTVIEVGVNVPNATAMVIMDADRFGVSQLHQLRGRVGRGAAAGLCLLVTEAPEVSPARTRLDAVAATLDGFELSRIDLEQRREGDVLGQAQSGTRSSLRMLTVIADEDIIAAAREEATALVAADPSLAGHPELRSALDSLVDASREDYLEKG
>NC_017586.1|WP_014145114.1|4719554_4720073_+|hypothetical-protein
MAFRHINELPLGEKVFRIELASEDDTTVTVTLSGWHESDPDTLLASGELRLPLQDVASLRLAVNRALRAIALVADVAEPIPDRDVLRELYPGHGAPWVPQHEQELVRRFHDGETVARISARFGRTPDSVRTKLRELGHDPRRPEYCPPDGCLSWSRYASPALVGAAEEPGRG
>NC_017586.1|WP_014145115.1|4720142_4720724_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MTRVIAGAAGGRRLAVPPGQGTRPTSDRAREGLFSTWQALHGPLTGARVLDLYGGSGAVGLEALSRGAAHVLLVEADARAVRVIRENVRALGLPGAEVRAAKAEKVVAGPPPADPYDVVFLDPPYAVSDDELREILITLAAGGWLAADAMVTVERGTRGGQFHWPAGFEGLRARRYGEGTLWYGRAAQVTDAS
>NC_017586.1|WP_014145116.1|4720720_4721233_+|pantetheine-phosphate-adenylyltransferase
MTHPESEESPLRRAVCPGSFDPITNGHLDIIARASRLYDVVHVAVMINKSKQGLFTIDERISLIEQVTAEFGNVRVESFHGLLVDFCKQREIPAIVKGLRAVSDFDYELQMAQMNNGLSGVETLFVPTNPAYSFLSSSLVKEVAAWGGDVSHLVPAPVMEALRGKLGKDR
>NC_017586.1|WP_014145117.1|4721363_4722497_+|hypothetical-protein
MDVQKKLDEIVAAVEGARSMPMSASCVINRAELLAMVRDLQAALPEALSRAEAVIGDREQVVAEARAEADRVIAAAHEERAALISGTEVARHAQEEADRLLAEARAEADEVRAEADEYVDSKLANFEVVLTKTLGSVDRGREKLLGRDPGASPAEQADPEYDAAPERTSDPDELRRRADAYVDAKLGAFEAVLAKTLEAVGRGRQKLTGHRPIDDLAAHLAAQDALGAAPQSDDEYLAGLAAGLNQTPVAPAVPAPSQPGDYGYPQQPGYAPAAAGYEGTGYQDPSLGYGTTAEPQHPGYQGYYGTYQEQPGGYGDWPAHHGYQEAVGQAPAPQTHPQQPQGAHAHVPQQPAGLDETSFFDTSLIDLNQLRELDGGR
>NC_017586.1|WP_014145118.1|4722641_4723301_+|DUF177-domain-containing-protein
MHRGKQEAINARLDHRDPLVLDTRELGRRPGAMKRIARTVPAPADLGVADVIGVPASAEIELDLRLESVMEGVLVTGTARAPVTGECVRCLEPIERELETDFQELFSYPDAGEGFGGHADEADGDEEEELLQVEDDLIGLEPVLRDAVVLELPLQPVCREDCPGLCADCGARLADDPGHHHDATDIRWAALQGLADSLQGGEKDNMSGAEGGVDEKQEK
>NC_017586.1|WP_041824911.1|4723303_4723477_+|50S-ribosomal-protein-L32
MAVPKRKMSRSNTRHRRSQWKAAPVTLVACERCHEPKQQHIACPSCGTYNKRQVLEV
>NC_017586.1|WP_014145119.1|4723496_4724285_+|ribonuclease-III
MSDADRSPHKRGGDPAQADTASSHTLLEGRLGYTLEPALLVRALTHRSFAYENGGLPTNERLEFLGDSVLGLVVTDTLYRVHPDLPEGQLAKLRAAVVNSRALAEVARGLELGRFVRLGRGEEGTGGRNKASILADTLEAVIGAVYLDQGLDAASELVHRLFDPLIEKSSNLGAGLDWKTSLQELTATEALGVPEYLVTESGPDHEKTFTAAARVGGVTYGTGTGRSKKEAEQQAAEAAWRAIGAKRDAAAKAAGSAEPAAS
>NC_017586.1|WP_014145120.1|4724379_4725258_+|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase
MPELPEVEVVRRGLERWISGRTVAEVTVLHPRAVRRHPAGAEDFASRLRGTVLGPARRRGKYLWLLLDDGGSLLGHLGMSGQLLVQPLDAPAETHLRVRIRLADDLGTELRFVDQRTFGGLSVHPCVPDGPDAAVGLPLPLAHIAPDPLEAAFDEDAFHAALRRRRTTIKRALLDQSLISGVGNIYADEALWRSRLHYDRPTATLTRPRTAELVGHIREVMNEALAVGGTSFDSLYVNVNGESGYFDRSLDAYGREDEPCRRCGTAIRRRPWMNRSSYYCPRCQRPPRPTAG
>NC_017586.1|WP_014145121.1|4725268_4725679_-|helix-turn-helix-transcriptional-regulator
MDDATVTAPAPDEDIDLAYDVFARSCPSRHTLEHVTGRWGALTLGALSENTLRFNELRRRVDGVSEKMLSQTLHALERDGLVHREDRQTNPPRVEYRLTPLGESVAERLLSLIELIEGKMPEVLAAQHRYDGRRPA

Crispr_ID: NC_017586_8

• CRISPR_ID: NC_017586_8
• CRISPR_location: 4919060-4919161
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: DinG

Consensus repeat of NC_017586_8

Consensus_repeat	Method
CCCGGGCCCTCGGGCGGGGCCGCG	CRISPRCasFinder

spacers of NC_017586_8

>8.1|4919084|54|NC_017586|CRISPRCasFinder
CTTCCGGGTACCGGCACCGGCGTGGCCCACGACGCGGGCCGGGGAACGGCCCGG

CRISPR arrays and Neighbor proteins around NC_017586_8

CRISPR arrays

The CRISPR arrays of NC_017586_8

>merge|NC_017586|8|4919060-4919161|CRISPRCasFinder
CCCGGGCCCTCGGGCGGGGCCGCGCTTCCGGGTACCGGCACCGGCGTGGCCCACGACGCGGGCCGGGGAACGGCCCGGCCCGGGCCCTCGGGCGGGGCCGTC

>NC_017586|8|8|4919060-4919161|CRISPRCasFinder
CCCGGGCCCTCGGGCGGGGCCGCG	CTTCCGGGTACCGGCACCGGCGTGGCCCACGACGCGGGCCGGGGAACGGCCCGG
CCCGGGCCCTCGGGCGGGGCCGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017586.1|WP_014145286.1|4933574_4934993_-|MFS-transporter	unknown	unknown	gnl|CDD|129794
NC_017586.1|WP_014145285.1|4932808_4933585_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|225130
NC_017586.1|WP_014145264.1|4906068_4906284_-|antitoxin	unknown	unknown	gnl|CDD|379416
NC_017586.1|WP_014145273.1|4915097_4916330_-|hypothetical-protein	unknown	unknown	gnl|CDD|237605
NC_017586.1|WP_041824925.1|4925908_4926679_-|transcriptional-repressor-LexA	unknown	unknown	gnl|CDD|234688
NC_017586.1|WP_014145287.1|4935145_4935550_-|glyoxalase/bleomycin-resistance/extradiol-dioxygenase-family-protein	unknown	unknown	gnl|CDD|319925
NC_017586.1|WP_041824922.1|4909562_4911668_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl|CDD|223394
NC_017586.1|WP_014145277.1|4921935_4923699_+|IucA/IucC-family-siderophore-biosynthesis-protein	unknown	unknown	gnl|CDD|226715
NC_017586.1|WP_014628469.1|4906721_4907669_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl|CDD|234626
NC_017586.1|WP_014145272.1|4913498_4915013_+|GTPase-HflX	unknown	unknown	gnl|CDD|274455
NC_017586.1|WP_014145268.1|4907853_4908402_+|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014145282.1|4928238_4931160_+|vitamin-B12-dependent-ribonucleotide-reductase	unknown	unknown	gnl|CDD|235828
NC_017586.1|WP_014145284.1|4931397_4932642_+|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl|CDD|238797
NC_017586.1|WP_014145281.1|4927317_4927953_+|transcriptional-repressor-NrdR	unknown	unknown	gnl|CDD|234774
NC_017586.1|WP_014145276.1|4920988_4921792_+|acetyltransferase	unknown	unknown	gnl|CDD|379237
NC_017586.1|WP_014145274.1|4916661_4918101_+|diaminobutyrate--2-oxoglutarate-transaminase-family-protein	unknown	unknown	gnl|CDD|235892
NC_017586.1|WP_014145278.1|4923775_4925752_+|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl|CDD|224120
NC_017586.1|WP_014145265.1|4906308_4906536_-|hypothetical-protein	unknown	unknown	unknown
NC_017586.1|WP_014145271.1|4911776_4913345_+|M1-family-metallopeptidase	unknown	unknown	gnl|CDD|341066
NC_017586.1|WP_014145269.1|4908464_4909352_+|diaminopimelate-epimerase	unknown	unknown	gnl|CDD|234768

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_017586.1|WP_014145278.1|4923775_4925752_+|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	5.2e-130	429.4	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017586.1|WP_014145286.1|4933574_4934993_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.67124e-56
NC_017586.1|WP_014145285.1|4932808_4933585_+|MBL-fold-metallo-hydrolase	gnl|CDD|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	1.0635e-15
NC_017586.1|WP_014145264.1|4906068_4906284_-|antitoxin	gnl|CDD|379416	pfam14013, MT0933_antitox, MT0933-like antitoxin protein. This family of proteins contains the MT0933 protein, which has been identified as an antitoxin to /protein MT0934. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 90 amino acids in length.	4.65473e-10
NC_017586.1|WP_014145273.1|4915097_4916330_-|hypothetical-protein	gnl|CDD|237605	PRK14086, dnaA, chromosomal replication initiator protein DnaA.	0.00601687
NC_017586.1|WP_041824925.1|4925908_4926679_-|transcriptional-repressor-LexA	gnl|CDD|234688	PRK00215, PRK00215, transcriptional repressor LexA.	1.70103e-115
NC_017586.1|WP_014145287.1|4935145_4935550_-|glyoxalase/bleomycin-resistance/extradiol-dioxygenase-family-protein	gnl|CDD|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.00608e-16
NC_017586.1|WP_041824922.1|4909562_4911668_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl|CDD|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	1.91641e-154
NC_017586.1|WP_014145277.1|4921935_4923699_+|IucA/IucC-family-siderophore-biosynthesis-protein	gnl|CDD|226715	COG4264, RhbC, Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism].	4.1961e-169
NC_017586.1|WP_014628469.1|4906721_4907669_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl|CDD|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	2.88819e-148
NC_017586.1|WP_014145272.1|4913498_4915013_+|GTPase-HflX	gnl|CDD|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	1.02841e-169
NC_017586.1|WP_014145282.1|4928238_4931160_+|vitamin-B12-dependent-ribonucleotide-reductase	gnl|CDD|235828	PRK06556, PRK06556, vitamin B12-dependent ribonucleotide reductase; Validated.	0
NC_017586.1|WP_014145284.1|4931397_4932642_+|3-phosphoshikimate-1-carboxyvinyltransferase	gnl|CDD|238797	cd01556, EPSP_synthase, EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.	2.95394e-143
NC_017586.1|WP_014145281.1|4927317_4927953_+|transcriptional-repressor-NrdR	gnl|CDD|234774	PRK00464, nrdR, transcriptional repressor NrdR.	5.09521e-85
NC_017586.1|WP_014145276.1|4920988_4921792_+|acetyltransferase	gnl|CDD|379237	pfam13523, Acetyltransf_8, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.19877e-54
NC_017586.1|WP_014145274.1|4916661_4918101_+|diaminobutyrate--2-oxoglutarate-transaminase-family-protein	gnl|CDD|235892	PRK06938, PRK06938, diaminobutyrate--2-oxoglutarate aminotransferase; Provisional.	0
NC_017586.1|WP_014145278.1|4923775_4925752_+|ATP-dependent-DNA-helicase	gnl|CDD|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	6.12143e-139
NC_017586.1|WP_014145271.1|4911776_4913345_+|M1-family-metallopeptidase	gnl|CDD|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.9387e-134
NC_017586.1|WP_014145269.1|4908464_4909352_+|diaminopimelate-epimerase	gnl|CDD|234768	PRK00450, dapF, diaminopimelate epimerase; Provisional.	3.03113e-109

Protein sequences

>NC_017586.1|WP_014145274.1|4916661_4918101_+|diaminobutyrate--2-oxoglutarate-transaminase-family-protein
MPTAEGRPSPPQGAAPADGPGVPGGADAILGRQAARESAARTYARSLPVVPVRARGMTIEGADGRRYLDCLAGAGTLALGHNHPVVLEAIRAVLDSGAPLHVLDLATPVKDAFTTALFETLPPELAENGRIQFCGPAGTDAVEAAVKLVRHATGRSGLLTFTGAYHGMTAVSLAAGGDTTARAAVGEADARITRLPYPYDYRCPFGVGGDRGAELSARWTATLLDDPKGGLQPPAGMLLEVVQGEGGVVPAPDAWLRRMRQLTKDRGIPLIADEVQTGVGRTGAFWAVEHSGIVPDVMVLSKAIGGSLPLAVVVYREELDTWHPGAHAGTFRGNQLAMAAGTATLRYVRENRLHERAARIGARMLTRLRGLAAHYPCVGDVRGRGLMIGVELVDPARPRDEYGALPAAPRLAAAVQAQALRRGLIVELGGRHGSVVRLLPPLTITDEQAEAVLDRLSDAIAAAERTAQHPGVIPGQGSA
>NC_017586.1|WP_014145273.1|4915097_4916330_-|hypothetical-protein
MPHPPATARRPQQPAPRAPRARRNRPAAWTAAAVTAALALTATACGPSDTKADGKPAATASAGQGQDGHHGLRLPSGFPTSLADLEKWKHGDWRKWDSWARRAADFANPVIKDLWKPRRMAEAKDRPVPQVPPNIGGDQGVSDPAPRPVQAVPVPTPYHRSAGPVGKIFFDTPQGSFVCSGTVVRDPAHPGRSNLVWTAGHCVHKGKAGGWYRNIVFVPSYNDDGLSAAAAASAPRQQVAPDGVWWADWAGTSRQWIDTGAESGGSGSPYDFAVLHVHPENGTGKSLEETVGAALPVWFDAPSATAISRMGAWGYPAAPPFDGARMFDCLDKPGRLSLDPSMPTEYRIGCTMTGGSSGGGWFAKRPDGTVALVSNTSIGPSDNTWLAGPHLGAEARSVFDAVSGRFAAAG
>NC_017586.1|WP_014145272.1|4913498_4915013_+|GTPase-HflX
MTNSTSSSSAARSAAADRQRLPESLRATALMEEDVAWSLDVDGERDGDQFDRSERASLRRVAGLSTELQDVTEVEYRQLRLERVVLVGVWTDGTVQDAENSLAELAALAETAGALVLDGVIQRRDKPDPATYIGSGKAQELRDIVLESGADTVVCDGELSPGQLIHLEDVVKVKVVDRTALILDIFAQHAKSREGKAQVALAQMQYMLPRLRGWGQSLSRQMGGGGSGSAGGGMATRGPGETKIETDRRRIREKMAKLRREIAEMKTSRDLKRQERRRHQVPSVAIAGYTNAGKSSLLNRLTGAGVLVENALFATLDPTVRRAETPSGRLYTLADTVGFVRHLPHHLVEAFRSTMEEVADADLVLHVVDGAHPVPEEQLAAVREVLRDVGAADVPEIVVINKADAADPLVVQRLLTHEKHAIAVSARSGEGVAELLALLDAELPRPRVEIEALVPYTHGALVSRVHVGGEVISEEHTAEGTLLKARVHDQLAAELGPFALAVQR
>NC_017586.1|WP_014145271.1|4911776_4913345_+|M1-family-metallopeptidase
MTRIAFRKATALAAAACAVLFTTAAQPQEPPRTGLGDRLYPALGDPRIHVGAYDITLDYHGNDKPLDAVTRMEARAVTGFDRFHLDFTHGTVRKVTVDGRPAAFRTTGEWLEITPGHHVEAGRPLRITVTHTSDPSGTDGQGGWVRTADGLALANQAVAAHHVFPCNDHPSDKAFFTFRITTPKGITAVAGGLPAGRPASGGTARAATTTWTYTTAHPVATELAQVSIGRSTVLHRTGPHGLPMRDVVPTADRTVLADRLALTPAQLSWMEGQVGPFPFETYGVLAVNTATGFELETQTLSLFERRLLVAPVAYVAPLMIHELAHQWFGDSVTPAAWSDVWLNEGHATWYEWRYRGEKKYGDSLDAQAKRAYQIDALARAAYGPPARPKVPPAGSKLGIFRENVYGGGALVLYALRHEIGDHAFRELERAWVTEHRDGNVTTHDFVALASRVAGRDLSGFLNGWLYGAKPPAMPGHPDWKPLTKLPVATALPGSPGAATRPGGRPAGRAQRPAPAVPAPVRR
>NC_017586.1|WP_041824922.1|4909562_4911668_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MDAVPAVSGGNERRRGLTRPTLRRLGRAALFGSAGGRDRLPDAIEHVAKVHRAHHPRADLDTLRRAYLLAESSHRGQLRKSGEPYITHPLAVTLILAELGAETTTLTASLLHDTVEDTDVTLEQVRAEFGEEVCYLVDGVTKLEKVDYGAAAEPETFRKMLVATGNDVRVMSIKLADRLHNMRTLGVMRPEKQARIAKVTRDVLIPLAERLGVQALKTELEDLVFAILHPEEYARARDAMVRHDSAPDPLAAVAERVRTVLRDAGIAAEVAIRPRHVLSVHRARLKRGGELGGSEYGRLLVLVAEDADCYAVLGELHTCFTPVIAEFKDFIAAPKFNLYQSLHTAIADRDGAITEILVRTRRMHRVAEAGVIALGNPYTTAEGDGGEESPGRTDPTRPGWLSRLLEWQRDASDPDTFWTALRDELAQDREITVFSADGGTIGLPAGATCVDAAYAIDADTGHACIGAQVNGRLVSLGTPLRDGDTLHLLMAAGEASGPSPQWLAHARTPAARIAISRWLAAHPATAEDEPVSHPVRPVPAPDPPAPAEPVALTDRPGAAVRLARCCTPVPPDEVTGFVIRGGTVAVHRKQCPQVTRMTAAGRTLSTVRWRDDPPAAGYLVTVRAEALGRPRLLADLTEAISAAGVGILAADVEPPQQHRVRHTYTIELPRAGALPELMRAMRRVPGVYDVYRTRPEVAATP
>NC_017586.1|WP_014145269.1|4908464_4909352_+|diaminopimelate-epimerase
MHPTHSGLPFLKGHGTENDFVIIPDPDGALELSAAMVARLCDRRAGIGGDGILRVVRSAAHPEAAAMAGEAEWFMDYRNADGSIAEMCGNGVRVFARYLQHAGLVGEGDLAVATRAGVRRPHIAKADADGTPGRITVDMGRATLHPDQVEVTVGDRRWPARHVNMGNPHAVAFVDDLRHAGRLLDAPEVSPASVYPEGVNVEFVTDRGPRHVAMRVHERGSGETRSCGTGACAVAVATARRDGVDPAVTGEPADYTVDLPGGRLLITERPDGTVEMTGPAVIVAEGVVDPAWLGR
>NC_017586.1|WP_014145268.1|4907853_4908402_+|hypothetical-protein
MAMEAGHRDRPQSERPGDELPGLPAAGFPDLPELPEPPGAAGLPELPTVPDALTADGPDSTGHDPEQAAQGSSFRELRPPRRLRVWQLIPIVGLGTVGSLMFAFPLAFEFGDGGPVVAMLGLLLSCCSAGWAIMAARRVGYTWPGLPARGSGDRPDWRFVAGYTAFAVLVALLAVWRVARLR
>NC_017586.1|WP_014628469.1|4906721_4907669_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MNNAVPYARTPQVIAVVGPTAAGKSDLGTALAERLGGEVVNADSMQLYRGMDIGTAKLTPAERRGVPHHLLDVWEVTRTASVAEYQELARAEIDRLLAAGRVPVLVGGSGLYVRATIDALRFPGTDPAVRARLEAELDEHGSGALHARLAAVDPRAARSILPGNGRRIVRALEVIEITGAPFTANLPAAGPEGAVYDTLQIGVDVPRPVLDERITARVDRMWRDGLLEEVRRLEKSGLRDGLTASRALGYQQVLAHFAGECTEQEARDETVRATKRFARRQDSWFRRDPRVHWLQGDAGELAEQALALLERPVTA
>NC_017586.1|WP_014145265.1|4906308_4906536_-|hypothetical-protein
MGVLEWFRRRSAAGAAVATEAPAQPGPAATPAGDSEPATRPADGRTDAADEAVGIPKQQSAGEAADSETGKGAHT
>NC_017586.1|WP_014145264.1|4906068_4906284_-|antitoxin
MGFLDTIKGKLNRGKAEDLARQHGDQVKGGMDKAGGALDERTGGKYGDQIRGGEEKAKGSYDEWKGGDQGS
>NC_017586.1|WP_014145276.1|4920988_4921792_+|acetyltransferase
MPSTDSNTGLPSIGPAPDDLRADPSGAEPRQPASGEDVRGDAPADTDDTLDLTLPQDVLDLLEEPVTAPGPGDPATDADLLDDLPDWGPVRTPRGVFQLVPVVLSRDLPIVARWMNDPAVAEYWQLAGPERITETHLRAQLDGDGRSRPCLGVLDGTPMSYWEIYRADLDPLARQYPARPHDTGIHLLIGRIADRGDGLGSVLLRAVADHVLDRRPACTRVVAEPDLRNTPSVAAFLAAGFRFAAELRLPDKSAALMIRDRTLRHLL
>NC_017586.1|WP_014145277.1|4921935_4923699_+|IucA/IucC-family-siderophore-biosynthesis-protein
MLHHPPELTAETWSHVSRRLLAKLLAELAYEEVIAPRPETPPADGPADYRLVLDDCAYRFRARRGAYGHWSVEPASITPTGDPFHFLRHARHTLGLTGQTLGHLVRELNATLAADSRLAAHALPVAELAGLDYAALEGHQTGHPWLVVNKGRLGFSAVDADRWTPEARRPGPLPWLAVRTTLAAYRGVPALATAERLYAGELDPAVRHTFDATLRDRGLDPAGYLYLPVHPWQWDETVLPLFAGQIATADVVPLPSDGDLRLPQQSVRTFLNVSHPDRHTVKLPLSILNTLVWRGLPTERTLAAPAVTGWVHALRDADPFLRDECRVILLGEVASVTVHHPFYDRVPEVPYQYKELLGAIWREPLDRHLRPGERARTLAALIHTDPEGRSFTAELVRRSGLDPATWLRRLFAALLPPLLRFLYRYGTVFSPHGENAVVVFDADDVPVRLAIKDFVDDVNVSDEPLPELDAMPDEVRRVLLTEPPDFLPQFIHSGLFIGVFRYLAPLCAEQLGVPESCFWGLVREEILRHQARFPELKDRFALFDLLVPRIDRLCLNRNRLYRDGYRDRPQRPHAAVHGTVANPLHVS
>NC_017586.1|WP_014145278.1|4923775_4925752_+|ATP-dependent-DNA-helicase
MSKPALTDLLHAAVAAVGGVERPGQVAMAEAVAAAVDDGSHLLVQAGTGTGKSLGYLVPALAQGERVVVATATLALQRQLVERDLPRTVAALKPLLRREPQFAMLKGRSNYLCLHRVHEGVPSDEEDGLFDPMEQMGGPTSKLGKDLVRLRDWADETETGDRDALSPGVSDRAWAQVSVSSRECLGATKCAYGAECFAEAARERAKLADVVVTNHALLAIDAIEGAPVLPSHEVLIVDEAHELVSRVTGVATGELTPGAVNRAVKRSARLVDEKAADRLLTAAEGFERVMELALPGRLEEIPEDLAYVLAALRDACRQVITAIGDVRDKSVPDEDAVRKQALASVENVHGVAERLLEGSEYDVIWCERHDRFGASLRVAPLTVSGLLREKLFAERSVVLTSATLKLGGDFNGVAASLGLAPEGVADTEGEGEAPPWQGIDVGSPFEYRKQGILYVAKHLATPGREGSRSDMLDELAELIEAAGGRTLGLFSSMRAAQAAAEAMRGRLDFPVLLQGEETLGELIRTFADDAGTCLFGTLSLWQGVDVPGSNCQLVVMDRIPFPRPDDPLMSARQKAVEEHGGNGFMAVAATHAALLMAQGAGRLIRASGDRGVVAVLDPRLATARYGSFLRASLPDFWYTVDRNQVRRSLAAIAAAADA
>NC_017586.1|WP_041824925.1|4925908_4926679_-|transcriptional-repressor-LexA
MTTTADSATITAQDHAQDRLNPMPTTNEDTPKPGRALPGRPPGIRADSSGLTDRQRRVIEVIRDSVQRRGYPPSMREIGQAVGLSSTSSVAHQLMALERKGFLRRDPHRPRAYEVRGSDAPHSQPTDTTGKPSASYVPLVGRIAAGGPILAEESVEDVFPLPRQLVGDGELFVLKVVGDSMIEAAICDGDWVTVRRQPVAENGDIVAAMIDGEATVKRFKRENGHVWLLPHNAAYQPIPGDEATILGKVVAVLRRV
>NC_017586.1|WP_014145281.1|4927317_4927953_+|transcriptional-repressor-NrdR
MHCPFCRHPDSRVVDSRTTDDGTSIRRRRQCPDCGRRFTTVETASLMVIKRSGVTEPFSRDKVIAGVRKACQGRPVTEDALAQLGQRVEEAVRATGSAELSTHDVGLAILGPLRDLDLVAYLRFASVYRAFDSLEDFEAAIAELREAGAGAPTAAGCRCGRPEEGSDDGSERPGHDQPSARPAGPRSGAERSGAPQGGGTKVPAPSGPGAD
>NC_017586.1|WP_014145282.1|4928238_4931160_+|vitamin-B12-dependent-ribonucleotide-reductase
MTETASGPARSSRKGEKGAKADKATKGLRMERIHTTPGIHPYDEVVWERRDVVMTNWRDGSINFEQRGVEFPDFWSVNAVNIVTSKYFRGAVGSPQRENSLKQLIDRVVKTYRKAGEENGYFASPADAEIFEQELTYALLHQVFSFNSPVWFNVGTAQPQQVSACFILSVDDSMESILDWYKEEGMIFKGGSGAGLNLSRIRSSKELLSSGGNASGPVSFMRGADASAGTIKSGGATRRAAKMVVLDVDHPDIEAFVETKVKEEEKIRALRDAGFDMDLGGDDITSVQYQNANNSVRVNDEFMKAYEQGAKFGLRARMTGEVIEEVDAKALFRKMAEAAWACADPGIQYDDTINHWHTSPESGRITASNPCSEYMHLDNSSCNLASLNLMKFLRDDTASDGASGAGGNMSFDAERFAKVVELVITAMDISICFADFPTEKIGETTRAFRQLGIGYANLGALLMATGHAYDSDGGRALAGAITSLMTGTSYRRSAELAAVVGPYEGYARNADAHKRVMRQHADANTAAKRMDDLDTPVWAAATEAWQDVLRLGEQNGFRNAQASVLAPTGTIGLMMDCDTTGVEPDLALVKFKKLVGGGSMQIVNNTVPKALKRLGYQPEQVEAVVAHIAEHGNVIDAPGLKPEHYEVFDCAMGERAISPMGHVRMMAAAQPFLSGAISKTVNMPESATVEEIEEIYYEGWKLGLKALAIYRDNCKVGQPLSAKKKEEAKTEAPAEVEKVVEYRPVRKRLPKGRPGITTSFTVGGAEGYMTANSYPDDGLGEVFLKMSKQGSTLAGMMDAFSIAVSVGLQYGVPLETYVSKFTNMRFEPAGLTDDPDVRMAQSIVDYIFRRLALDFLPFETRSALGIHSAEERQRHLDTGSYEPAEDELDVEGLAQSAPRQAGPAKAATTAPAAKAQEPAAAPSPKQAHNSTELLEIQQGLNADAPLCFSCGTKMRRAGSCYVCEGCGSTSGCS
>NC_017586.1|WP_014145284.1|4931397_4932642_+|3-phosphoshikimate-1-carboxyvinyltransferase
MTVVEIPGSKSVTARALFLAAAARGTTVLRGPLVSDDSEGFAEGLITLGYQVERGPDAWTITGRPEGPAVNEADVYCRDGATTARFLPALAAAGHGLFRFDASAQMRRRPLGPLTRALRDLGVDLTHQEEEGHHPLTVRAAGIKGGQVTLDAGLSSQFLTALLLLAPLTEEGLRITVTDLVSVPYVEITLVMMRRFGVETVREGDTFVVPPGGYRATDYPVEPDASTASYFLAAAALTGRRVTVPGLGAGSLQGDLRFAEVLRSMGAEVTLTRDSVTVTGADGGRLRGLTVNMRDISDTVPTLAAIAPFADGPVRIEDVYNTRIKECDRLDACAENLRALGVPVATGRDWIEIRPARPAAARIACRGDHRIAMSFSVTGLRTPGITLDDPGCVKKTFPGFHEALAALRTAWETE
>NC_017586.1|WP_014145285.1|4932808_4933585_+|MBL-fold-metallo-hydrolase
MAELTIEYVGGPTAVIEAAGLRLLTDPTFDGPGEHPVGSRSLTKTAGPALAPDAVGPVDAVLLSHDQHPDNLDTSGRAFLARAPLVLSTEAARDRLGDPVRALPAGEWAELPRPDGGTLRITGVPAQHGPDGSESLVGQVTGFLLTGQGVPTVYVSGDNASLDVVRSIADTHGPVDVAVLFAGAARTPLVPDAYLTLTSEQAAEAARILGARQVVPLHFEHWGHFTQGRQTLLDAFATAGDGVRGTLRLLEPGERLTL
>NC_017586.1|WP_014145286.1|4933574_4934993_-|MFS-transporter
MHRDSAPPAPVRTPAGEPPDHHPVLTLLVACTGFFVITLDVNAVTVALPHIGRELGVGVTALQWVLDAYTLLFAALMLSAGTVSDRFGATRVYAVGLAGFTVMSAACALAPDAAFLIGARAAQGAAAALMLPASLSLIRRTRTDPAERARGFALWTAASGVAVAAGPVAGGVLTQALGWRSIFFLNVPVGVAALAALSRTPRIRPRPAPLDGAGQSAVVLALAALVFAVIEGGATGFGSPEVAVASAVAVAAGTAFLAVEARVRHPAVPPALFRERAVAVCTAAGLTMNLGFYGAVFVLSMFFQTQRHLSALVGGVMFLPMTGLIAVVNVVSGRVIARYGPRLPLAAGQLLAGAASLALPAVGPGTPVPLLSAALLPLGVGAGLAAPALTTTMLEAVPAERSGLASGVLNAARQTGGAVGVALFGAFIGGGRFLPGMRLSLLTGGVALLCTGTAVAVLLRGDGGRRRPAVTG
>NC_017586.1|WP_014145287.1|4935145_4935550_-|glyoxalase/bleomycin-resistance/extradiol-dioxygenase-family-protein
MDALHPRLLVRDFDTSLRFWTAALRALHGIEPVKVVPEARYANWDLDGQAVLVIFARENIVRIVGTDSLPEHAAAQDTGMLVLRVADTDDAAARLAAHGATVVAAPQDRPEWGPGLRTAHLRDPEGNLIELQSY

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_017586_6	6.1|3299868|31|NC_017586|CRISPRCasFinder	3299868-3299898	31	NC_022061	Mycobacterium phage KayaCho, complete genome	56955-56985	6	0.806
NC_017586_6	6.1|3299868|31|NC_017586|CRISPRCasFinder	3299868-3299898	31	KJ433975	Mycobacterium phage 40BC, complete genome	56823-56853	7	0.774
NC_017586_6	6.1|3299868|31|NC_017586|CRISPRCasFinder	3299868-3299898	31	KJ433973	Mycobacterium phage 39HC, complete genome	56823-56853	7	0.774
NC_017586_6	6.1|3299868|31|NC_017586|CRISPRCasFinder	3299868-3299898	31	MT639653	Arthrobacter phage Elezi, complete genome	18777-18807	7	0.774
NC_017586_6	6.1|3299868|31|NC_017586|CRISPRCasFinder	3299868-3299898	31	MN703413	Arthrobacter phage Powerpuff, complete genome	18981-19011	7	0.774
NC_017586_6	6.1|3299868|31|NC_017586|CRISPRCasFinder	3299868-3299898	31	MT024869	Arthrobacter phage Lego, complete genome	18930-18960	7	0.774
NC_017586_6	6.1|3299868|31|NC_017586|CRISPRCasFinder	3299868-3299898	31	MT889366	Arthrobacter phage London, complete genome	18777-18807	7	0.774
NC_017586_6	6.1|3299868|31|NC_017586|CRISPRCasFinder	3299868-3299898	31	MT024871	Arthrobacter phage YesChef, complete genome	18981-19011	7	0.774
NC_017586_6	6.1|3299868|31|NC_017586|CRISPRCasFinder	3299868-3299898	31	MH019216	Streptomyces phage Wentworth, complete genome	44498-44528	7	0.774
NC_017586_1	1.6|643858|32|NC_017586|CRT	643858-643889	32	NZ_CP044329	Methylocystis rosea strain BRCS1 plasmid unnamed1, complete sequence	135038-135069	8	0.75
NC_017586_1	1.5|643857|33|NC_017586|CRISPRCasFinder	643857-643889	33	NZ_CP035514	Haematobacter massiliensis strain OT1 plasmid pOT1-4, complete sequence	154928-154960	9	0.727
NC_017586_1	1.6|643858|32|NC_017586|CRT	643858-643889	32	NZ_CP035514	Haematobacter massiliensis strain OT1 plasmid pOT1-4, complete sequence	154928-154959	9	0.719
NC_017586_1	1.6|643858|32|NC_017586|CRT	643858-643889	32	NZ_CP029827	Burkholderia sp. JP2-270 plasmid p1, complete sequence	4871-4902	9	0.719
NC_017586_1	1.2|643797|32|NC_017586|PILER-CR,CRT	643797-643828	32	NZ_CP020952	Rhizobium sp. CIAT894 plasmid pRheCIAT894e, complete sequence	341657-341688	10	0.688
NC_017586_1	1.5|643857|33|NC_017586|CRISPRCasFinder	643857-643889	33	NZ_CP029827	Burkholderia sp. JP2-270 plasmid p1, complete sequence	4871-4903	10	0.697
NC_017586_1	1.6|643858|32|NC_017586|CRT	643858-643889	32	NZ_CP011667	Streptomyces sp. Mg1 plasmid pSMg1-3, complete sequence	66831-66862	10	0.688
NC_017586_1	1.6|643858|32|NC_017586|CRT	643858-643889	32	NC_014120	Paraburkholderia sp. CCGE1002 plasmid pBC201, complete sequence	368379-368410	10	0.688
NC_017586_1	1.5|643857|33|NC_017586|CRISPRCasFinder	643857-643889	33	NZ_CP011667	Streptomyces sp. Mg1 plasmid pSMg1-3, complete sequence	66830-66862	11	0.667

1. spacer 6.1|3299868|31|NC_017586|CRISPRCasFinder matches to NC_022061 (Mycobacterium phage KayaCho, complete genome) position: , mismatch: 6, identity: 0.806

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
gcgccctcggcctcgggggccacggtgcggc	Protospacer
***.***** *************** *  *.

2. spacer 6.1|3299868|31|NC_017586|CRISPRCasFinder matches to KJ433975 (Mycobacterium phage 40BC, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
gcgccctcggcctcgggggccacgacgcggc	Protospacer
***.***** **************. *  *.

3. spacer 6.1|3299868|31|NC_017586|CRISPRCasFinder matches to KJ433973 (Mycobacterium phage 39HC, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
gcgccctcggcctcgggggccacgacgcggc	Protospacer
***.***** **************. *  *.

4. spacer 6.1|3299868|31|NC_017586|CRISPRCasFinder matches to MT639653 (Arthrobacter phage Elezi, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
agggcttcgccctcggcggccacggcggcgg	Protospacer
. * *.********** ******** **** 

5. spacer 6.1|3299868|31|NC_017586|CRISPRCasFinder matches to MN703413 (Arthrobacter phage Powerpuff, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
agggcttcgccctcggaggccacggcggcgg	Protospacer
. * *.**********.******** **** 

6. spacer 6.1|3299868|31|NC_017586|CRISPRCasFinder matches to MT024869 (Arthrobacter phage Lego, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
agggcttcgccctcggaggccacggcggcgg	Protospacer
. * *.**********.******** **** 

7. spacer 6.1|3299868|31|NC_017586|CRISPRCasFinder matches to MT889366 (Arthrobacter phage London, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
agggcttcgccctcggcggccacggcggcgg	Protospacer
. * *.********** ******** **** 

8. spacer 6.1|3299868|31|NC_017586|CRISPRCasFinder matches to MT024871 (Arthrobacter phage YesChef, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
agggcttcgccctcggaggccacggcggcgg	Protospacer
. * *.**********.******** **** 

9. spacer 6.1|3299868|31|NC_017586|CRISPRCasFinder matches to MH019216 (Streptomyces phage Wentworth, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
tcgtcctcgccctcggcggcgacgatctcgt	Protospacer
 *************** *** ***.   ***

10. spacer 1.6|643858|32|NC_017586|CRT matches to NZ_CP044329 (Methylocystis rosea strain BRCS1 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

atcgc-cacccggccccgcacgcacgagcgcgt	CRISPR spacer
-tgacgtgcccgctcccgcacgcacgagcgcat	Protospacer
 * .* ..**** .*****************.*

11. spacer 1.5|643857|33|NC_017586|CRISPRCasFinder matches to NZ_CP035514 (Haematobacter massiliensis strain OT1 plasmid pOT1-4, complete sequence) position: , mismatch: 9, identity: 0.727

catcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
cgcgcgcccccggccccgcacccaccagcgcga	Protospacer
*..   * ************* *** ****** 

12. spacer 1.6|643858|32|NC_017586|CRT matches to NZ_CP035514 (Haematobacter massiliensis strain OT1 plasmid pOT1-4, complete sequence) position: , mismatch: 9, identity: 0.719

atcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
gcgcgcccccggccccgcacccaccagcgcga	Protospacer
..   * ************* *** ****** 

13. spacer 1.6|643858|32|NC_017586|CRT matches to NZ_CP029827 (Burkholderia sp. JP2-270 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.719

atcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
gcgcgtatccggcgccgcacgctcgagcgcgt	Protospacer
..   .*.***** ******** *********

14. spacer 1.2|643797|32|NC_017586|PILER-CR,CRT matches to NZ_CP020952 (Rhizobium sp. CIAT894 plasmid pRheCIAT894e, complete sequence) position: , mismatch: 10, identity: 0.688

aaccgagggcggcgcatgccacccgtgcgatc	CRISPR spacer
ggccgagggcggcgcaagccgcccggccatgt	Protospacer
..************** ***.****  *.  .

15. spacer 1.5|643857|33|NC_017586|CRISPRCasFinder matches to NZ_CP029827 (Burkholderia sp. JP2-270 plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.697

catcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
tgcgcgtatccggcgccgcacgctcgagcgcgt	Protospacer
...   .*.***** ******** *********

16. spacer 1.6|643858|32|NC_017586|CRT matches to NZ_CP011667 (Streptomyces sp. Mg1 plasmid pSMg1-3, complete sequence) position: , mismatch: 10, identity: 0.688

atcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
gcgctgacccggacccgcacgcgcgagcgccc	Protospacer
..  . ****** *********.******* .

17. spacer 1.6|643858|32|NC_017586|CRT matches to NC_014120 (Paraburkholderia sp. CCGE1002 plasmid pBC201, complete sequence) position: , mismatch: 10, identity: 0.688

atcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
tgcgccacccggcgcctcacgcacgctgggtc	Protospacer
  *********** ** ********   *  .

18. spacer 1.5|643857|33|NC_017586|CRISPRCasFinder matches to NZ_CP011667 (Streptomyces sp. Mg1 plasmid pSMg1-3, complete sequence) position: , mismatch: 11, identity: 0.667

catcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
tgcgctgacccggacccgcacgcgcgagcgccc	Protospacer
...  . ****** *********.******* .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	670246 : 679100	12	Rhodococcus_phage(33.33%)	terminase	NA
DBSCAN-SWA_2	1772638 : 1790879	26	Mycobacterium_phage(40.0%)	portal	NA
DBSCAN-SWA_3	1797771 : 1804327	8	Gordonia_phage(33.33%)	tail	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_017586|670246:679100|DBSCAN-SWA
GTCAGGTACCGGGCCGGTAGTCGCGCAGCCAGTCCATGGCCTGCGCGGCGCCGTTCTGGCTACCCAGGAGGTACAGCAGCGCCTGGCTGGTGGCGTCCACCTGGTCGTCGTGGGGGGCGTTCGGGAAGGAGGCGGTCTCCTCGACGTACTCCGCGATCCACGGGGCGAGGTCGGGGGCCGGCAGGTGGACGTTCCCAGCTTCCACGAAGGGGGCGACGGCGGAGGCGCGCGCGTACTTGCTGCCTGCCGGGTTCACCGGGATCAGGCCGGGCACGGTGGCGCGCAATTGAGCGACGATGGCGGGCCCGTTGGCTTTGTCTTCGACGAGCTTGGCGTGGCTCTGGGGCCACTTCGCCGAGAGAGCTTCCACGGCGCGACATGCGGCGGGGAAGTCGAGGCGGTCGCGGACCTGGTCCAGCAAGAACACCTGCGCGCCGATCTTCGCCCACACTTGTCCGACTACGAAGTCGGCTTTCGCGGAGTCCTTGAAGGTCATGTCCCACGACTGGATGACCTGGTGGGCCGCGGGTACCCACCAGGTGCCGTCCGGGCGGCGCTCTGCCCGTAGCGCGGTGTACCACTGCCAGTGTGCGCGCTTGAACAGCCCCCCTTCGGCCGGCGCCGGGCGCCCTTGGTACAAGGCATTCCACGTGCGGGCGCCAACGTCCTGCTTGGTGTCCTCCCAGTCCTTGATGGTCCGGCCCCGCGCTGACAGCAGGTACTCACCGGGGGCGCGGCCGAGCGGGTCGTCGTCGCTCTCAGCCTGTGCCGGGATGTTGATGTGCCGCCAGTCACCGCGGGTGTCCTGGGCGAGCAGTCTCCCGGCGAGGTCGTCTTCGTGCCAGCGGGTGAGGACGACGATCACCACCGCCTCGGGGGCAAGGCGTGTGCGAGCGGTATCGGTCCAGAAGTCCCACACCCGCTCGCGGAACACTGCGGACTCGGCCTGGGCGCGGTCCTTGATCGGGTCGTCGATGATCAGTACGTCGACCGGGCGGCTCGTCAGCGCACCGGCCACGCCGACGCTGTACACGCCACCGATGTGGTCCCGGAGCTGCCATTCCTGCGCGCTGGAGGTGTCGCCTCGGATGTACAACCCGAGGGCATCGGGGTGGGACCTGATGTCGTTGCGGATCGCGCGTCCCCAGCGCATCGCGGTGCGCTGCTCGTAGCTCGCGATGGCGACGCGTAGGTCCGGGTTCCGCGACAACATCCACGCCGGAAAGGCCCGGGAGACACGCTGTGACTTGCCTTCCTGGGGAGGCATCGTCCAGATCAGCCGCCGGCAGCGACCGGCGGCGACGTCCATCAAGTTGGCGTCCAGGAGTTCAAGGGCGGGCGTGGCCACGATCCGTGGGTCGAGGGCCTTGGCCAGGTGGTGGGGGGCGGGGTATCGGTCGGCGGCTGCATTGCGGCCTTCGAGCCGGTCGGCCGCGCGCACGAGCGCGTTCAGGTCGGACATGTGCAGGTGCCTCTGGCCGAGGGTGCAGGGGCTTGTGAGAGGGGGTGAGCGCGGGACCGAGGGTCACGGGGCGGTGGGTAGGGCGATATGGAGGCTGTCGAGGACCATCACGGCGTCCGGGACGCTGATGTAGGCGAACTCCCAGTCGGTGCGGCCGTCTCGGTCAACGGTGGCGGTCCACTCGGCGGTGGTGGCCTCGTCGTACCAGTAGTACTCGCCGGGGCCGGACTGAGCGATCCCTCGGGGCGCGTCTTCGAACAGGCCCGGCAGCAGCCTGTCCAAGACGACGCCGGCGACGTGTGGGAGGCCGGTGAACTCAATGGTGGCGCGGGTGTGATCGTCTACGCACACGGTCCCGGATCCGACGCCTGCCCGTTCCCAGCGCAGGCGTGTGGGGCAGCAACCGGTCGGCGGCGGCACGTCCACGAGCAAGGGGAAGGCGGTGCGAAGCGCGGTAGCAGCACTCTGGTGCTGGCGGGTGAACGCCTCTCGCCAAATGGCGAGTGCTCGTGCGGCGTCGGGCTGCACAACACCTCCCTCCCACTCGGAGCACCCGTCTTCACGCCACAGAACGCAGGTGCCGGGCAGCGGCTTGGCGAGCCGCCACGGCGGCGGCTCCGGTGATCCCCGCAGCCGCGAGGCCGGCTTCGAGCGCCGACACCAGCGCTTCGGCCTGGCGCTCGGTGACGCGTGCCATACGGTCTTCGATGTTCAGCCGGGCGATCATGCCGAGGATCTGTCCGGCCCGGTCCATGGCCCGCTCGTACAGGGCGATCTCGGCCCGGAGTTGCTCGGTGCCTGCCGCTCCCTCGTACCGGATGCGGTCGCCGAGGCGCTGCACCATGCCGCTGATGGCTTCCTGCCAGGCGACGGCCTGGCCGGCGAGCCGGGCCAGCGCTGCGAAGGGGTCAGCGACTGCCTCGACATTCAGGTCGGCGAGAACGGCGCGGGCCTCGGCTTCGGCCTGCTCGGTGCGTGCTGCGGCGCGCTGGTTGCGGGTGTTCCCACCGTGGAGGCGACACCGGCCGAACCCCACGTGATCGGTACCCCAGCCCGCCACCAGGCTGCAGACGTCACCGGGAGCGCCCTGCCGCTTCTGGGCGCCGCACTGGGGTGTGCCGTCCGCGGCCTGTTCCGGCTTCAGGCTCACTCGTCACTCCGGCGGTGCAGGCGTTTGATGCGCTGCCGGCGGTCGGCGATAGTCAGTACCCGGTCGACCGCAGCCAGGTCTCCCTTCATCGCCGGGCCCCACAGGGCCGCTTGCAGTCGGTCATACCGCAGGGCTTCCAGCATGCGCTCCGGGTCGAGCGGCGGCCCGTCGTACTGCTCGTCAGCGATCTCCCCTGCGGCGAGCACGGCGTCGGCCACATCCGGGTACCCAAGCTTGGTGGCGATGGTCTGCCAGTCCACTCCGGCCAGCTTCAGCGCGAGGGCTTGACTGGCGCGTTCACGGTCGCGGGCATCCATCGGCGGGCTCCCTATCGGGTCAGGAGGGTATGGAGGTCAGCACGCGCCTGCGGGTCGGTCAGGAATCGACCGGTGTAGGAGGCGGTGACCATGGACGCCCCCGGCTTGCGGGCGCCGCGGTGCGCCAGGCAGCCGTGTTCGGAGCGGATGATGCAGGCCGCGCCAAGGGTGTCCAGATGCTCGTCCAATGCGGCGGTGACCTGCCGGGTCAGCTGTTCTTGGGTCTGCAAGCGGCGGGCGTACACGTCCAGTACCCGCGGCAGCTTGGACAGGCCGGCGACCGACGCGCCGGGCTTGGGCTGGTACGCGATGTCCGCAGTGCCGCTGAACGGGAGCAGGTGGTGTTCGCACAGCGAGGTGAACGGCACGCCGGTGACGGCGATGGGCTGCCCGGCATGGTCGGCCGGGAAGGTCCGCGACAGGTGGAATGCCGGGTCGTCGCGGTACCCGGCGGTGAATTCGCCGAGCGCTCGCAGCACTCGCGTGGGGGTCTCGGCCAGAGCCGGGCTGTCGGGGTCCAGGCCGATCGAGGCGAACCATGCGGTCAGGCCGGCGGTGAACCGGCGGGCGGCGACGCGGAGGGAGGGGTCGGGGTTGGTCATCGTGCCCTTTCGTTGCCCCAGGTGAGGACGTGGAGCCGGGTGGTCAGGTTGTAGCCCGCGCGAATGGCGGGGTCGGCGATGACGGCCAGGTGGCGGCCGATGGTGGCGGCGTCGGTACCGCGCGGCATGATCCACACCTGCTCCGGGGGAATGCCCAGCGCCTGCACCCACTTCTCGGTCTCGGTGACGTCCTCGGCCGAGGCGCAGACGTACTTGAAGGTGGCTTGGCCGGTGTCGCGTAGCGCGTGGATGGCGTCTTCGCGGATGCGTCTGCTCTCGCGGTCACCGGCGCTGGCGAGTTTCGGCGAGACGTTGAACCGCGTGGCCCATGCGGTGGTGAGCGGCGTCGGCGCGATCGTGCCGTTGGTCTCGATCTCGATGTCCACCCCGGCGTCGGCGAGACGGTCCAAAAGATCCAGCCAGCCCGGCTGGTGCTGGTGCAGCAGTGGTTCGCCGCCGGTGATGACGACCACAGCGGGAGCGCCTTCCAAGGCGCGGGCGGCGATGTCGGCGGTGGGCTGGCGGGTGAGCTGGGTGCGCAGGTCGTAGCGCGTCGCGTCCCACGTGTAGGGAGTGTCACACCAGGAGCAGGTCAGGTTGCACCCGCCGAGCCGTATGAAGGCGGCGCGCCGGCCGGTGGAGGGACCTTCCCCCTGCACGGTCGGCCCGAAGACCTCCGCGACGACGAGGGTCGGGCCGCTCATGATGCAATCCAGGTAGCGGCGTTGACGTGGGTCTCGGCCAGGTGGACGCGGGTGACGCGGGCGCCGGGCGCTCGGACCAGGTCCCGGAGTACGCCGGCGGCCATGTCGGCGAGCAGGGCGGCGACGTTCTCCACGGTCGGCCATCCGGTCACCTCGTAAGCCTTGCAGTCGAAGGAACGCAGAACGGGCAACAGCGGGTCGTTAGGACCGAGCATGACCCCGTGGTCGAGGTGGGTGTCGATCCACTGGCGCAAGGCCCGCTTGAATGGCCCGAACTCGACGACGAGGCCGGCGGCGAGCTTGGGCGCTTCGACGGTGACTTCGGTCCACCAGGAGTGGCCGTGCAGGGAGGTGCACTTGCCCGGCAAGTGGGGCAGTCGGTGGGCCGTCTCGAAGTTGTGGCGGACGGTCACGCTGTGGGTCATTCCAGGCGTCCTCTCATGATGATGCGGGCCAGGATGACGCTCTGGTCTCCCGAGCCTCGGGTATCGGCGAGGGGGTAGGCCGCTTGCGGCCTCACGATCCGGGCAAGGGCGGAGTACCTGTTCGGCGCCGGAACCGCGGCGTGTTCGTGGTCGGCGCACCCGAGGGCGCGGCCTGGGGCGACTTACGTCGACTACAGGCGATGACCACCAGGTCAGGGGAGGTCACACCGCATAGTCGGTGGGGTCGGGTACGCCAGCGTCAGCGAAGGCTTCGCGGCGTTCGGTGCACGTACCGCACGTGCCGCAGTGCTGCTTTTGGCCCTTGTAGCAGCTCCACGACAGGCCCAGTGGGGCACCGAGTAGATGTGCGTGCTCGGCGATCTGCGCCTTGGTCCACGTGATGAACGGCGCCTCGATGCGGGGGGTGTGGTGGCCCTCAAGTGCCCGGGTGACGCAGGCCCTCAGGGCGTCGAGGAACGCCGGGCGGCAGTCGGGGTAGATAGCGTGGTCACCGGCGTGGATACCGAGGCCGACGAGCTGTGCTCGGCGAGCGGCGGCGATCCCGACCGCGATGTTCGCCATGATCGCGTTGCGGTTGGGCACGACGGTGACGCGCATGGATTCGGCCTCGTAATGCCCGTCCGGTACCTCGATCGCTGGATCGGTGAGGGCGCTTCCGGGCATCAGTGCGCCGACGGCCGTCAAGTCCACGACCTGGTGTTCCGCGTCGAAGTGCTGGGCGACCCGCCGAGCGGCGAGAAGTTCGCGGCTGTGCCGCTGGCCGTAGTCGAAGCTCAGCAGCATCATCTCGTAGCCGCTGTCGTGGTAGTGCGCGGCGAGAGTGGTGGAGTCCATGCCGCCGGAGAAGGAGAGCACGGCGAGGGGGCGACTCATGAGGTGTTGTCCTTCCGGGCGTCAGCGGCCAGCGCGCGGGCGGCCACGGTGAAGTTCTTGGTATCGGTGTCGGCGAGGAACAGGCCGGTGCCGGTGCTGGTCCACCCCGGCGGCGGGGCCACGTGGTGACGGCGTTCGAGCCAGCGGCCAAGGCGCCCGTAAGCCACTGCGGGGGTGGCGCGGATCATGGTGTCCTCGGCCTGGAACTGCTCCGGCGGCTTGCCTGCCTTGGTAGCGAAGCCCCGTCGGCCGACGACTGCGGGGTCTGCGCCGTGGGTGCGCAGGAGCCCGGCGTGCTTGCGGGCTTCGGCTGGCCGGCCCACGGTCAGCTGCACGATGCGGGAGTGCTGGCTGTCCCACAGCGACATCACTCCGAAGCGTGCGCCGGACGCCCAGCTGGAGGAGTCCACTGTGTAGAACGGCAGCGCGGCGATGGTGGCGAACCGGGTCTGGCCGAAGCCGTGGTAGACCGCGCCGTGGTGGCGTGCGATGCGGAAGGCTCGGATCAGCCAGCGCATCACGTCGTCGGTGCGTCGGGCGTAGGGCACCATTCCGCCCAGCGCGATGTACCGGTAGGAGGCGCACAGTGCTTCGAGGCGCCGCCAGGGGGATCCGATGTGGAATACCGGCAGGACCCGGATGCCCTGGTCTTCGAGGGCGAGGGTGTTGCGGTGGGTGGCGTCGGGGTCGCCGATCACGTCAAGGGTCGCGGCGGTGGTGATCACGTGGCGCCACTGGTGCAGCCAGGCCGCGTAGTCGGCCAGCTTGATGGTCGAGCCAGTCGTCGCGGCGGAGAATGCCCCGGAGTCAGCGAAGACCTCGTAGGGGCCGCCGTAGGCGGCGCCTATCGCGGCGAGGTCGGTCTCGCGGTGGTAGTGGAAGCTGGTCAGGTAGCGGAACACGGGGCTCCTGGTGCGAGGGTCCGGGCGGCGAGGCGCATCTGCTCGTCGTCGGTGCAGGCGAGGAACAGGCAGGTGCCGGTATCCGACCAGCCAGCCGGTGGAGGAACACGGTGGCGTCGCGCGAGCCATGTCTCCAGGCGGTGGAACGCGGTCATCGGGGCGGCGCGCATCATGTCGTACTCGCGAGCGTGCTCAGCCGCAGTGCGATGAGCGGTGTGGGCGAACCCTGGTCGGCCGACGACTGCGGGGTCTGCACCGTGGGTGCGCAGGAGCGCGGCGTGCTTGCGGGCTTCGGTTGGTCGGCCGACCGGCACGGTGACCAGGCGGCAGCGCCGATCGTCCCACAGCGTGATGTTGCCGTACCGGGCGCCGGATACCCACGCGGAAGAGTCCACGGAGTAGAACGGCAACGCGGCGATGGTGGCGAACCGGGTCTGGCCGAAGCCGTGGTAAACCGCGCCGTGGTGGCGTGCGATGCGGAAGGCTCGGATCAGCCACCGCATCACGTCGTCGGGGCGCTTGGAGTGCGGGACCATGCCGCCGAGGGCGAGGTAGGCGTGGCGGCTGCACAGGTCCTCCAGCATCGGCCAGGGGGTGCCGACGTGGAAGGCGGGCAGGACGTTCAGTCCGGCATTCAGCAGCGTGGCGGTGTTGCGGTGGGTGGCCTCGGGGTCGCCGATCACGTCCAGGGTCGCGGCCGTGGTGATCACGTGGCGCCACTGGTGCAGCCAGGCCGCGTAGTCGGCCAACTTGATCGTCGAGCCAGTCGTCGCGACGGAGAACGCCCCGGAGTCAGCGAAGATTTCCACCCGGCCGCCGTGAAGGGCTTGGAGATCACCGACGAGTTCCCCCATATCGGTGTCGCGCCAGTACGCGTACGACGTCAGGCAGCGCAGCGTCATCTCACCGCACCCCCTCCTCCAGCAACATCCGCAGTGGTGCGATGTCCTGGTCCCGCGCTCCGGAAAGAGCGAGGTACACCTTGGTGCCCTGGTCGGCGGCGCGGGGCAGCGGCGGCGCAGGTACACGGTGGCGGGTGGTCAGGGACCCCTCCATGAACTGGTAGGCGCGGGCACAACCGGCTGTGAGCAGATCCCGGTCGGCTCCGGTGGATCCGGCGGCGGGCCGCATGAAGTTGCGGTCCAGCAGCCGGTGTGGCGGCAGGCCGTGTGCGCGGACCAGCGCAGCGTTCGGCAGTACGTCGGCGGGGTTGCGGAAGAACAGGCTGCGCATACGGAGAGTGCGGGCGTCCCACAGGTAGACCAGACCGAAGCGTTGTCCCATCGTGTAGGAGCTGCTGTCGATCGAGTAGAACGGCAGGTGGCGGACGAGATTGGCGGAGGTCAGCCCGAAGCCGTGGAGCGCGGTGCCGTAGGGCCGAGCGACTTTGAAGGCGCGGATCAGCCAGGCCATGAGCGCCTTCTGCTTGGCGGCGCCTGCGGCGTGGAGCGCCAGCCCGCCGAGGGCGATGTACCGGTGCTGGGCGCACAGCCCTTCCAGCACGTCCCAAGGCTCACCTGTGTGAAACACCGGCAACACGCTGCAGCCAGCCTCGGTGAGGCGATCCAGGTTCGCGGCGGTGGCCCGGTGGTCACCGATCACGTCAAGGGTCGCGGCGACGGTAATCAACGGCTGCCAGTGTCGTAGCCAGGCAGCGTAGTCGCCCAACTTTATCGTCACGCCGGTCGTCGCAGCGGAGAACGCCCCGGAGTCGGCGAACAGGTCCACGTTCCCGCCGAGATCGTGCACCAGGGCGGCCAGGTCGGTATCGCGGTGGTAGTGGTAGCTGGCCAGGACCCGCAGCGTCACGCCATCGACCGCAGCTTGTTCATGAGGTGGATGAACCGTGCCGCGTCGTCGTCCGGTGTCTCGCACCCGGACGACAGGTCGTAGAAATCGTCGCGTACGTTGGGCGGGACCTTGAACCGCAGTACGGGCCACAGGTCGTCGTCCTCAGGCTCGCCGAACTCGGCGGCGAGTGCGTCCAGGTCCGGCGGTGGTGTGATCAGCATCTCGACGTCGGTCTCGGTGTAGCCGGTGCCGGTGTAGTCCCCGTCGAGGTAACTCAGCAGCTCCGCCAAGGCGTCGTTGTCGTATGTGCCCAGCTCCGCCAAGCGGTTGTCCGCCAGGTTGATGCGCCGGGCCTCGGCGTCATCGCACCTGACAATCTCGCACCGCGCGGTCTGCGCGCCTTCGGCGGCGAGAGCCTGCAAGGTGTGGTTTCCCGCGAGGACGATCAGCGGTCCGCTTGGTATCTCCCGGACGATCAGCGACCGGTACTGTCCGTTCCGGCGCAGGCTCTGGCGGATCGCCTCGACGTCCCCCCTCTTGGCGTTGCCGGGGAACAGCATGAGTTCGTCCAGGGGAACGTCGCGGGTGGTGACGTACTCGGCAGGCAT

Protein sequences of DBSCAN-SWA_1

>NC_017586|670246:679100|675795_676701_-|WP_014627371.1|DBSCAN-SWA
MFRYLTSFHYHRETDLAAIGAAYGGPYEVFADSGAFSAATTGSTIKLADYAAWLHQWRHVITTAATLDVIGDPDATHRNTLALEDQGIRVLPVFHIGSPWRRLEALCASYRYIALGGMVPYARRTDDVMRWLIRAFRIARHHGAVYHGFGQTRFATIAALPFYTVDSSSWASGARFGVMSLWDSQHSRIVQLTVGRPAEARKHAGLLRTHGADPAVVGRRGFATKAGKPPEQFQAEDTMIRATPAVAYGRLGRWLERRHHVAPPPGWTSTGTGLFLADTDTKNFTVAARALAADARKDNTS
>NC_017586|670246:679100|672266_672857_-|WP_014141344.1|DBSCAN-SWA
MSLKPEQAADGTPQCGAQKRQGAPGDVCSLVAGWGTDHVGFGRCRLHGGNTRNQRAAARTEQAEAEARAVLADLNVEAVADPFAALARLAGQAVAWQEAISGMVQRLGDRIRYEGAAGTEQLRAEIALYERAMDRAGQILGMIARLNIEDRMARVTERQAEALVSALEAGLAAAGITGAAAVAARQAAARHLRSVA
>NC_017586|670246:679100|678506_679100_-|WP_014141353.1|DBSCAN-SWA
MPAEYVTTRDVPLDELMLFPGNAKRGDVEAIRQSLRRNGQYRSLIVREIPSGPLIVLAGNHTLQALAAEGAQTARCEIVRCDDAEARRINLADNRLAELGTYDNDALAELLSYLDGDYTGTGYTETDVEMLITPPPDLDALAAEFGEPEDDDLWPVLRFKVPPNVRDDFYDLSSGCETPDDDAARFIHLMNKLRSMA
>NC_017586|670246:679100|674476_674905_-|WP_014141348.1|DBSCAN-SWA
MTHSVTVRHNFETAHRLPHLPGKCTSLHGHSWWTEVTVEAPKLAAGLVVEFGPFKRALRQWIDTHLDHGVMLGPNDPLLPVLRSFDCKAYEVTGWPTVENVAALLADMAAGVLRDLVRAPGARVTRVHLAETHVNAATWIAS
>NC_017586|670246:679100|675127_675799_-|WP_014141349.1|DBSCAN-SWA
MSRPLAVLSFSGGMDSTTLAAHYHDSGYEMMLLSFDYGQRHSRELLAARRVAQHFDAEHQVVDLTAVGALMPGSALTDPAIEVPDGHYEAESMRVTVVPNRNAIMANIAVGIAAARRAQLVGLGIHAGDHAIYPDCRPAFLDALRACVTRALEGHHTPRIEAPFITWTKAQIAEHAHLLGAPLGLSWSCYKGQKQHCGTCGTCTERREAFADAGVPDPTDYAV
>NC_017586|670246:679100|677604_678510_-|WP_014141352.1|DBSCAN-SWA
MTLRVLASYHYHRDTDLAALVHDLGGNVDLFADSGAFSAATTGVTIKLGDYAAWLRHWQPLITVAATLDVIGDHRATAANLDRLTEAGCSVLPVFHTGEPWDVLEGLCAQHRYIALGGLALHAAGAAKQKALMAWLIRAFKVARPYGTALHGFGLTSANLVRHLPFYSIDSSSYTMGQRFGLVYLWDARTLRMRSLFFRNPADVLPNAALVRAHGLPPHRLLDRNFMRPAAGSTGADRDLLTAGCARAYQFMEGSLTTRHRVPAPPLPRAADQGTKVYLALSGARDQDIAPLRMLLEEGVR
>NC_017586|670246:679100|673772_674480_-|WP_014141347.1|DBSCAN-SWA
MSGPTLVVAEVFGPTVQGEGPSTGRRAAFIRLGGCNLTCSWCDTPYTWDATRYDLRTQLTRQPTADIAARALEGAPAVVVITGGEPLLHQHQPGWLDLLDRLADAGVDIEIETNGTIAPTPLTTAWATRFNVSPKLASAGDRESRRIREDAIHALRDTGQATFKYVCASAEDVTETEKWVQALGIPPEQVWIMPRGTDAATIGRHLAVIADPAIRAGYNLTTRLHVLTWGNERAR
>NC_017586|670246:679100|672853_673174_-|WP_014141345.1|DBSCAN-SWA
MDARDRERASQALALKLAGVDWQTIATKLGYPDVADAVLAAGEIADEQYDGPPLDPERMLEALRYDRLQAALWGPAMKGDLAAVDRVLTIADRRQRIKRLHRRSDE
>NC_017586|670246:679100|671770_672058_-|WP_041824366.1|DBSCAN-SWA
MCVDDHTRATIEFTGLPHVAGVVLDRLLPGLFEDAPRGIAQSGPGEYYWYDEATTAEWTATVDRDGRTDWEFAYISVPDAVMVLDSLHIALPTAP
>NC_017586|670246:679100|670246_671707_-|WP_014141342.1|terminase|DBSCAN-SWA
MSDLNALVRAADRLEGRNAAADRYPAPHHLAKALDPRIVATPALELLDANLMDVAAGRCRRLIWTMPPQEGKSQRVSRAFPAWMLSRNPDLRVAIASYEQRTAMRWGRAIRNDIRSHPDALGLYIRGDTSSAQEWQLRDHIGGVYSVGVAGALTSRPVDVLIIDDPIKDRAQAESAVFRERVWDFWTDTARTRLAPEAVVIVVLTRWHEDDLAGRLLAQDTRGDWRHINIPAQAESDDDPLGRAPGEYLLSARGRTIKDWEDTKQDVGARTWNALYQGRPAPAEGGLFKRAHWQWYTALRAERRPDGTWWVPAAHQVIQSWDMTFKDSAKADFVVGQVWAKIGAQVFLLDQVRDRLDFPAACRAVEALSAKWPQSHAKLVEDKANGPAIVAQLRATVPGLIPVNPAGSKYARASAVAPFVEAGNVHLPAPDLAPWIAEYVEETASFPNAPHDDQVDATSQALLYLLGSQNGAAQAMDWLRDYRPGT
>NC_017586|670246:679100|673185_673776_-|WP_014141346.1|DBSCAN-SWA
MTNPDPSLRVAARRFTAGLTAWFASIGLDPDSPALAETPTRVLRALGEFTAGYRDDPAFHLSRTFPADHAGQPIAVTGVPFTSLCEHHLLPFSGTADIAYQPKPGASVAGLSKLPRVLDVYARRLQTQEQLTRQVTAALDEHLDTLGAACIIRSEHGCLAHRGARKPGASMVTASYTGRFLTDPQARADLHTLLTR
>NC_017586|670246:679100|676685_677603_-|WP_014141351.1|DBSCAN-SWA
MTLRCLTSYAYWRDTDMGELVGDLQALHGGRVEIFADSGAFSVATTGSTIKLADYAAWLHQWRHVITTAATLDVIGDPEATHRNTATLLNAGLNVLPAFHVGTPWPMLEDLCSRHAYLALGGMVPHSKRPDDVMRWLIRAFRIARHHGAVYHGFGQTRFATIAALPFYSVDSSAWVSGARYGNITLWDDRRCRLVTVPVGRPTEARKHAALLRTHGADPAVVGRPGFAHTAHRTAAEHAREYDMMRAAPMTAFHRLETWLARRHRVPPPAGWSDTGTCLFLACTDDEQMRLAARTLAPGAPCSAT

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014141342.1|670246_671707_-|terminase	phage terminase large subunit	A0A249XNL6	Brevibacterium_phage	1.2e-145	55.8
WP_041824366.1|671770_672058_-	hypothetical protein	NA	NA	NA	NA
WP_014141344.1|672266_672857_-	hypothetical protein	NA	NA	NA	NA
WP_014141345.1|672853_673174_-	hypothetical protein	NA	NA	NA	NA
WP_014141346.1|673185_673776_-	GTP cyclohydrolase I	A0A2H4GYC9	Pseudomonas_phage	4.6e-27	41.6
WP_014141347.1|673772_674480_-	7-carboxy-7-deazaguanine synthase QueE	A0A2P1JXY9	Rhodococcus_phage	1.2e-50	45.6
WP_014141348.1|674476_674905_-	6-carboxytetrahydropterin synthase	A0A2P1JXS3	Rhodococcus_phage	1.3e-15	36.2
WP_014141349.1|675127_675799_-	7-cyano-7-deazaguanine synthase QueC	A0A2P1JXV3	Rhodococcus_phage	1.2e-44	45.8
WP_014627371.1|675795_676701_-	hypothetical protein	A0A142F2D2	Mycobacterium_phage	2.7e-34	37.0
WP_014141351.1|676685_677603_-	hypothetical protein	A0A142F2D2	Mycobacterium_phage	3.4e-37	36.2
WP_014141352.1|677604_678510_-	hypothetical protein	A0A142F2D2	Mycobacterium_phage	1.7e-33	40.7
WP_014141353.1|678506_679100_-	ParB N-terminal domain-containing protein	A0A222Z9L3	Arthrobacter_phage	1.7e-18	35.9

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_017586|1772638:1790879|DBSCAN-SWA
ATCAGTGCTTGGATTCCTCCAGTTCCAGGACCGATCCCCAGGACCGGTCTCCGATCTCGCCCTCAGCCGGGATCAGCACGCCCCGGATGGTGAACTCCATGAGCCGTGCGGCTTCCCTGGTCAGCTCGGCAGCGGCATCGCGTGGGAAGCTGAACAGGATCTCGTCGTGGATCGGCAGCCGCATGTACGGCGCGAACCCGGCGTCCGCCAGGCGCAGCAGCGCGCGGGCCGTGATGTCCCGGCTCCCCGACTGGATGAAGTAGTTCAGGGCTGCGTACGCGCGTCCCCGGTCCACCGGCAGGCGCCTGCCGGTGGGGGTGTAGACGAACCCTGTCCGCCTGGCCTCGTCGGCGAGCTGCTTCGCCAGGACCCCGACGCGCGGGTATGTGTCGGCGAACGCGCTGAGCGTGCGCTTGGCGGTCTCCTCGTCCACGCCGAACTGTTCGACCATGGCACGCCAGCCGCCGCCGAACACGGTCAGGAAGTTCGCGCCCTTGCCTACCTTTCTCGGGACGCCGGCCGCGTCCGCGGTGATCTGGTGCAGGTCCAGGCCGTTGGCGAACGCGTGGAGCATCGTCGGGTCTTGGGAGAACGCGGCGAGGTCGCGCAACTCCATGTTTCCGAAGTCGATCGACACACTTACGTGTCCTTCCTCGGCGAGGAACATGTGCCGCACGTAGCCGTCCCCGGCCGGGAATGTCTGGGCGGGCACGCTGCCGGTGATGCTCATGCGTGCTGTGCGTGCCTGGATGGAGTTGATCGACGCGTGGACGCGCCCCCGGCTGTCTCTGCCGTCGAGCGCTCGCTGGAACCAGGTTGCCGACCACTTGCGGGCCCGTCGCGCCTTGATGACTGCTTCGGCAAGGGGGTGGTCGATGCCGTTGAGTACGTCATCGTCCATTGCCAGATTGCCCTTGGCTGTCTTCTTGGTGAGACGGATCCCGAAGCCCAGGAATGCGTCTACGAGCTGAGCGGTGGAGTTGATGTTCTCGACGCCATACCTATTGGCTACCTGCTCCCATCGCTCGTACTCGGCGGCCAGCTCCGCTAGGCGTGCTTCCGCATAGTCGGAGTCGAGCAGGTAGCCTGTGCGCTCGATAAGTCCGGTGACGTGGTTGAGGCGGTGTTCCCAGGAGAACAGGCCGCGCCTTTTGGTGCGTGCCGGCACGAGTGGCCAGAGGATGTGGAACAGGCGGTAGGCGAGGATGGGGTCCATTCCCGCGTAGAGCAGGAAGTCCTCATCGAAGAGTTCAACAATGGGCCATATCTTGTGCTTCGTGGTCTTGTATTTCCGGGCCAGGAGAACCATGCTCCCCTTGACCTCTTCGGCGACTACGGGATCGATGTAGTGTTTCGTCAGCTCTTCGAGTTTGAGGCCCGGCCCTTTCTCCTTGACTCCTCTGGGGTCTACGAGGTGTGCGGTGATCTTCGTGCAGATCGTCTTGGGCGCCAGAACCTCCAGGGGGATGCCCAGGGACGCCTCAATGACGTGCTGGTCGAAGATGGCGTTGTGTGCGATCAGCGTTCCGGCGCCGAGCAGTGCGCGTTGCGCAGCCCTGCGGTAGGGCTCCCCCAGCTCGACGGGGATCACGTAGGACTCGCTGCCGTTGCCGAACTGGGCCAGGCGCAGCCGGAATCCGCGGTCCCAGTCCCACCAGTTCAGGCCGGTGGTCTCGGTGTCGAACCCGAGCACCGGATTCTTGCCCAGCCAGCGGTCGAACTCCCGGATATCGTCTGTCGTCTCGACTACGTTGATCCGCACTTGCTGATGTTTGATCTTGTAGTGGAGATGCTTCAACTTACTCCCGGAATGCGCGGACTATGCAGTAGACGACGACCGCAACGGCGATAGTCAGGCACATGGCGGTGACCCCCGTTTCGATTGCTTTGAGCTAGCTGCCTTCGTAGGCCGATATGAGTACGAGGATCAGGAGCATGGCGAGCATGCCGTAACAGAAGGCGTAGATCACGGTGCGGACTCCTTGCAGTGGTGAGCTGTGGTCGCAGTGGCAATGTCCTGGGCAGTTACCGCATTGTTGTCGCAGCATGCGCAGCCTCCAGAGGCAATCTGGGTTTCGCATTTGGCGCACCACAGATCGACGCCGCCGTTTTCCAGTCCGTAGACGAGAATCCGGTTTGCTTCGGTCATCGGAATTCCTTCAGGCACCGGGCCGGCACGTGCGCGGCCGGTGAGTATTTCCATGCTTTGCACGGGCCTGCCATGTTCAGCCAGACGCCGAGTGCGAGCGCCAGCAAGAGTGCAATCACTGTCGTCAGGGTTTTCATGTGCCTCCAAAAGGGCGGGGCGCCGGTGGTGGCCGGCGCCCCGCGATCTGCTGTGGTCGATTACTTGGCCTTGAAGCCGCCGTCCTTCTGGCGCCACAGCGGTTCGCACTTGCCGCCCTCGGGGCCGTTGCAGAACATCGCGGCCCAATTCGCCTTCTCGACAAGGCTGCGGCCGTGGGGGCAGTCGTCGCCCGCAACGGCGGGAGGGGTCTTCGGGACCACCTTGCCGTTCTGGAAGGTCTTCGGCCCCGTGCCGCCAGCGCCTCCCTTGAACTGGCTGCGGGTGTAGTCGGCTGCCTTGGCGGTGAGGTCGATCAGCCCCTCTGCCTTGAGGGCGTTGAGCAGCGCGGCGCCCGCACGTGCGGTGTCCTCGGCGGTGTCGCCGTACACGGTGGGGGTCAGCCACTCGGCGTCATAGCCGCTGCCGGCCTTGAGCGTGAAGCCGATCTTGAATCGGGCAAGGTGGCGCGAGGTTTCAGGCATAGGCGCGGTCTCCTTCTTCGCGGTGGTGGTCTGGTGTGAGGGCACGTCCCACGGGGACTTGTCCTCGAAGGGGTCGGGGTAGCTCAAGATCACTCCACGGGTTGGCAATTCATTCGTTCGTCGGCGGGGTGTCAGATCGGGCAGGCGCCCGAGGTGCAGTCCTCGTCGTAGCTGGTGTCCACCGCGCGGTGGTCCAGGTCGGCCGTCAGCCGCTCGTACTCCTCGGCCGTGATGCGCTCGTACGGCGCCTGCGCCCGGCTGGACTCCGGGAAGACCGTGCTGCCCTTCAGTCGCGGCATGTAGTGCAGCAGCACACCGGCCAGGTCCTCGACGGTGTACTGGTCAGGGTCGATCACGGCCGTGTAGCTCACGGCCTGGTCCGCCCAGCACTGCTGGTACATCTCCTGCACGCTCAGCATGGCGTCCAGGTCGAGCTGGCCGGCGTGCTCGTATGCCTGCTCCAGCACCTCGTCCAGCAGCACGTCCCGCGTCGGGATCGCCACCACTGCCGTGTTGGCTGCGTAGATGCACGGCTCGACGTGGTAGCCGCTGCGCCGGTACTCCTCGACCTGCGCGGCCTCCGCCGGGTCCAGCAGCGAGAACCGGATGCGGCGGACGAAGTAGCCCGCGTACGGTGCATGGATCCCCTCCCCGGAGACGCCGGCCAGCTTGCTGATGGTCCCGGTCGGGGCCACCACGCGCCGCTTCACCGGCACGGGGATACGGAGCTGGGCGGCGTACTCCTGGGCAGCCCGGTCCACCACCGCGGCGTACGTCTGGAGGTCGTACGCCACCAGGCCGTGGTCGTGGTGCGCAGCCTGCGAGTACGGGATGCCCTGCTTGGCCAGGTAATCGGCGAGCCCGGTGTGCCCGACGCCGATACGGCGGTTCCGCGCGATCACCTCGGCCGAACGCCGGTCCGCGACCGGTGCGAACGTAGCCCGGACCAGGTAGCGGGTCAGCAGCCGGTGTGCCTCGTCCAGCTCTTCCCAGTCAGGGCGCCCGTCCTCGACGAACGCGGCGAGGTTGAGCGAGCCCAGGTTGCACGGCTCCCACTGGTTGAGCGTGGCCTCCCCGCACGGGTTGACCGTGTACGTCCCGTCCGGCTCGCCCACGGCCGACAGCGACGAGTTCCAGAACCCCGGCTCCCCGTCGCGCAGCGCGCCCTCGGCGATGGTGGTGAGCACCTTTCGCGCAGCGGGGTCTCCAGCCTCGGCCATGGTGATGAACTCGGAGTCCACCTCCACGGAGATGTTGGTGGTCCAGTGCTCGCTCTGCTCCCGCTTGCACCGGACGAACTCCTCAATCTGCGAGTCCCGCCAGTGCATGACCGACATACGCGCCGAGCGGCGCACACCCCCGGCCACGATGCACCGCGCGATCTCGTGATCGATCTCCATCGCATCCATGCCGGTAAGCGGGAACCCGGCGCAGTCGGCCAGGATCTCTCCGGTCCGGATCAGCAGCTCCGCGAACGGCGCCGGCCCGCTGGCCGTGCCGCCGAACGACCGCAGCGCAGCGCCCTTCCGGCGGAGCCGGCTCACGTCGTAGACACGATCGGTATGCCGCACCTGCGGGTTGTGGGCCGTGCGGATCAGGTCTGCGAGGGCGGCGGCCCAGCCCTCCCGCGAGTCCTCGACGGCATAGGCAACGTGCCAGGTGTAGGCATAGTCCCCGGACAGCAGCCCGGCTTCCGCCATCTCCGTGTAGTCAGGGTGCGCCGGGTCGCAGACGATGTGCACCTGGAGCGCGTTCTCCACGGCCGGGAACTCGGCAAAGTACCGGTTGCTGTAGTTCGCGCCGACGCCTCCTCCCTCGGCGAGCCGGAGCAGGGTGAACGTGAAGTGCTCTTCCGGCCGCGCCGGATCCCAGCCCGCGGCCCAGCAGTTGTTGAGGGCGTAGTCGGTGACGCCGCTGCCGCGCAGGTGGCGGCCGGCGGGCAGGACCTTGAACGTCTCGATCAGCTCGACCAGGCGCTCACGCTCGTCCGGCTCGATGAACTGTTCGTCCACGAGCGCAAGGTTGCCGTCGACCACGCGCTCGACGGTCTGAGGCCAGGTCTCCAGTTCCCCCGACGGCAGCTCCCGGCTGTAGGTGCGTTCGTAGACGGTTCGGGCGGTCTCGGTCCTCCAGGCCGTCACGCGGCTCCCCTCTTGGTTCGGATGTGGCGGTTCATGGACAGGGCCAGGGCGTCAACGGCCCGGTAACCTCGGCGCCGTTCGGCGTCATTCACCGGGGGCATTCCGTAGACGTAAAGCCGCTGGATCAATTCCTGATATTCGTTGCTCAGCTTCGGCAGCGCTGCGGCAGCGTCCAGCCGCGCGGGCATGATGTTGTCGGAGATCACGCACCGAGTCAGGTCGTCCTTCTTACCGACAACGTCTCCAATTTCGTCGTCCGTATAGACGAACGTACGCAGAACGGTCCGGACTTCATCGGGTGTGTAGTAATACTGATCGTCCATCAGGTCTCGGTAAGCGCGCTCCTTGGCCGCGTACCGGCGCCCGGCATTCCAAAAGACCTTGCGAATGAACTCGTGGTCCTCGGCATGCTCGGCGAGAGTGCGGCGCTCCTCCATCGCGTGCAGCAGGATTTCCTGCTTGACGTCATCGACTTCAACCACGCACCACTTGTTAGCGATCTCCCGGGCCACCTTGCCGGCCAGCTCGCTAAGCTGTCCCCAGTCGAGGTCCGTCATGCGACCGCCTTCATGGCGCTTTCCCAGGCCAGCTCAGTAGACCCGTCCGGGTAACGGACGATGTAAGTGAAGTCGCCATCCCTATCAGGTTCACTGGCAACACCAACGATCTTCCCTTCGCAGCAGTACACCTCGACCTTCTGCTCGATCTGGTACTTCGGAGACAGAACACGCTCGAAAACTCCGCCTACGCCGAACAGGGCACACTTCGCTATCTGAGGGGATGCCCACTCGTCACCGATGTAAGCGACGTATTCCGTGCCTCCGTGCTCGAACGGCTCAGCCACGGTGAAAAAGCTTAGCCCGCTCATTTTCGAACGGTACTCCCGCCCCTTCCACATACTCATGCCTTACCCCCCTTAGAAATGAACTTTCCGCGCGGTCCGCGCTTGATCTCGCCATACCGCTGGCCCTCGACCACGAACGATCCGTCGTCCTCGATCGGGATCGCGTGCGGAGTGGCGTTGTACTTGCCGACGTAGAACAGGCCGAAGCCCTTTTGCCAGTTGGCCGGCCCGTTCTTGAGATATCCGGCCTGGCGGACATCCATGAGATGTCCGACCTCGAACCCGTAGATGGTCCGGAGCTTTCCGTTATGCCCGGTGGTGTGCGGAGCGATGGCCAGCCGGTGAGTGTGCCCCATGACGATGCTGATTCCGGCCTTGGCCGCCTTGAGCCGCGCAGTCGCGCCAGCCACCTGGCTCATTCCCGGCGACTCGTGCCCGTGGACCGCCACCCATCCAGGCGCCAAGGGGTAATAGGGTTCGGCCTTCTTCACGTCGAAGGCCGGAAAGTCCAGCAGGGTCTCAAACCGGTAGAACGTGTCCTCGGCCGCCAGCGCCGGCGCCCGGCTGGCCAGATACTTCCGCGGCCGTTCGTCGTGGTTGCCTTCCAGCACCTACACGGGGCCGGAGTAGACCTCACGAAGCGGAGCCAAGAAGTTCCTCTTGGTGTACTCGGAGTCCCGGATCACATTCCCCTCGAACTCCGCCCGGGTACCTGCGGACCACCGCGACGGAGCCGGGTAGTCCACCAGGTCGCCGATCTGGATCACTTCGTCCGGCTGGTAGTCACCGATGAACGCGAGGACGTTCCGCAGCGCCCGCTTGTCTTCGAATGGCGCTTGCACGTCGGATATGACAACTATTCGCTTCACATGGCTCCTCGGGAGTAGGTCGGCTCCGGTAGGTCGATCTCGACGTACCGGCCCAACCAGCCATCGTTGACAGTGTTCAGGTCCATAGCGTGGATGGGCGAACAGTCGCCGTTATCCAACTCGTAGCCATCGGCGTAAGCGGCTTTGATCGCCGCTTCAATAGCCCTTGCGTGTTCTTCGAGAGTCAATCTGCTACCTTCAGACTCTCGATCTCGTAGTCGAGATACCAACGGGCCTTCTTCAGGTCCTCCAGCTCGTCACCCTTTCGCCCCGCCCGCATCAGGTACTTCAACGCGTTCCCACGGACGAACGAGAAGTGCCGAGTTATCTCGATGACTTCCATGCCTCCGGGCATCCAGGTGTAGTGGCCCGGGTGGTCGATGCCCTCCTCCTCCGTGGATGGTTCAGTGCTCGCGGGCATCAGCTCGTCCTCCGCGAACATGTAGCGGCGCCCGTCAGGGAACATCACCTCGTAGGGGAGGAAGTATCTGGAGTCAATGTCCGCGACCGTGCCGGTCTGGCCCTTCCGCTCCCGCAGCACGAAGGAATATTCCCTGCCCTTCGGGGGGCAAATGGTCACCTCGTCGTCCAGCCCGAACTTCAGCTTCACAGGCCGATCCTCTCTCTCAGCACGTCGAACCCGTACTCGTACGCGAACGAATTGGAGTCATGCCGGGGGGCCGGGATGATCACCTTTGCGTTGGGCATTTCGGCAGCGCGCTTCTCCGCAGCCGCAATGCCGGGCTCGTCTCCGTCGGCCACGTGGTAGACGTGCCGGAACCCCATGAAGGCGGGATCGAAGTGGGCGCGCCACGCTGAGGTGCCCTGGTAACCGACGGCCGGGACACCAGCCGCCTCCCATGTCATCGCGTCCATTTCGCCCTCGGTCACGACCACATTCGGGCTGGAGCCGATCAAGGCCATGGTGTTGTACAGCCGCGGCACATCCCCCGGGAGCGACCGGTACTTCCCGTGACCCTGGTGCCGCTCCTTCTGAAGCGGTGCGAGATACCGGCCTGCCTCGTCTTTCACGCACTCGTCGGCGATACAGCGGCACCGCACCGTGGCCACACCGTGTTCACCACCGGCCGGCCGCAAGTACGGGATGACGAGCATCCCTGCGTACTGCTCATGGCCAGTAAGAGCCGAACCGACGAATCCGATTCGAAACCGGTCGGCGACGCCGGCCAGCCCCCGAGCCTTCATGTACGCCTCGGCCGGACTCCCCTTGTACTGCCAGTGGTACGTCTTCGCTGCCTGTACCGAACCGGCTATCTGCAAACTCCTGAGCCTGTCTGAAGCCAAATCCCTCCTCCCTCTGGATCACGTCATAGCTGTCCTCGGACACGTCACAGACGAAACATGCCCATCGTTGAAAGCCGGTGTTTGCTGACGCGCTCGGATTCGTCTCCGGGTGAAGCGGGCACAGAATCTTCTGCCACCCGCTCCGGTCCCGAAGTTGGATGCCGTAGTAATGCTTCAGCACCAGGGCGATAGGCGGCTTACTGCTCACGCGCCGGCACCGGGTCCCCGACCTTCCGAACCGTGACGGGAAAGACATAGCGCTTCGAATTCCGCGCGTTCCAGTCCCGGCTTCCCTTCCACGCCCGGTAATCGAAGGCAACCGACTTGCGCTCACTCATCTTCAACCAGCCTTCCTCAACTGGCGCTCCTGGCGTAGGAGTCGCTTCAGATCCCAGTTCTCACGGACTAGAGACAGCAAGCTGTCAAAAGGCATCACCGAGTACGCCTCGCCGGTTCCCTTGAGCCTCGCTTTGATGACGACGGCGCCATTGGTGGCCTGCGGATTGTGCTCCAACTCGCGCTTCAACTCCCGCATGAAGCGGGCCAGGTCGAATCGCTGGACATTCTTCATCTCGAACACGAAGGCCAGAGGCGCCAGCGTGATGTCCCCGCGGTCGTTGACCCCGTACAGGGTCCCGTGGCGCCGGATCTCCTCCGGGTCGATCTCAGGAAACGCGGCCCGGATGTGGTCGAGGGCCTGCTTCTCCCACCGGTAGCCCTTGTCCTTGTTGGCCTTGGCGGTGGTCACCATCGCCCCTCCCCACTCTCAACGTAGAGGAACAGGATCCCCTGATTCAACTTCACGGACAAAAAAAATTGTGACTCAGAACTCACTCTCCAAGTCGGTGAGTCGCATGTTGGCGCTGTTGAACTCGTACGTTGTGAACGTCTGCCCCGAGCTGTCCTCGAACCCTTCGCGGTTCTTTACTGGACTCACGTGCAGCAGCCGCCCATCCATGCCATCGATCTCCTTGTGGATCGTCAGGATCACTGAAGGGACCCGGCCGATCTTTCCCTTCACCCCAGACAGCGGGATAGGCCGCAGGCCGTCACTGAACTCGCCCACGACATGGTGGAGCCCAAGAACGTGGGCCTGCGTGTCTCGGGCCATCTCTGACAGGTACTCACACATTGCCTCCAAGCCGAACGAGAAGTTCCCAGCATCCGCTTGGCCGTCTCCCCCATCCACATTGGTGATATTGTCCACCACGATGAGATACGGATATATACCGAAGACCTCGTAATAGCAAGCCAAGTCCTGCTCAATGTCACCCGGCGTCGGCCTTGCCTCGTAATTGAACCGTATCCACCAGCGCTCGCCCAGCGCCGCATGGTACTCCCCGAACTCGTCGGCGATCAGCTTGCGCTTCACCTCTCGTACGTTGTCCCCCGTCAGGATGGCAGTCGCGCGGGTGAGTTGCGTTGCCGCGTTGCTGTCCGCACTGAAGTACAGAACCGGGAGATTTCCGAACAACGCCAGGTTGATGGCGAACAAACTCTTGCCAGTGCCAGGGCCAGCAGCCACCAAGCTCAGCTCCCCGCGTCGAAACTCGACCTCCTGCCGGCGCAACCCGGCGAACGGGTTGGGGATCGGCTCCCCGGCCGAACCTTTGACCTCGACGCTCTGCGTTAGCGAGTACACGCACTCTCCCTCTCGATCCCCTGATTCAACTTGTAGCATAAAAAAAACAGCCGTGCGACACGTCGCAGAACCGGCACCCGTAGCCGGGGTTCGCCTCGAACCTCCCTGCCTTGACCCCGGCGTCCATGGTCGCGTAGCGCTCCCCAACCTCGGCAGGGCTCACCTGATCCAGGGCGACGGGACGGGACAAGCGACCATCCTTAGCCAAGTACCAGTCACCGCGTCGGACCGGCACGTCGTACAGGGACTCGATCGCCACGGCGTACGTCTCCAGTTGGAAGCGGCTCTTGATGCTCCCCGTCTTCAGGTCCCGCACCCGCACGGCGTCTCCGTCGGCCTCCATCACGAGCAGGTCAATGATCCCGCGGACGACGACTCCCCCCAGCTCGACCGTGAACCCCAGCTCCACCGCCGGCTTTCCGGCCGGTGTCGTCCACACCTCGGGGCGGTGCTCAGCCACCCAGTCAACGTACTGGGCCGTCTGCTCCTGGCCCAGGACGTAGCGGCGTTCGATCTCTTCGCCTCCGCTGTACCGGCCGGACGACAACCACCGATCGGTGTCCGGCTCGATGTCCAACGCATCCTGCACCAACCGGGCGTACTTGTCGGAGAAGGCTTCGACGGCTTCCTCAGCGGTCATCCTGCCGTTGGACAGCACCACGGCTTCCGCCACAGCGTGGAACGCGCTGCCGTGGAAGCTCCACGCCGCCGGCCGAGGCGTCACGCGCTCGACCCTGGCGAGGTAGTACCGCCAACCGCACTCCTCGTACTGCTGCACCTGGCTCACACTCCGGGGCTGTGTCTCTACGCTCAACGGGCTCAACCCATCACCACCTTGCTCACGCGAATGAATTCAAAAAACCGGCTGCCGAGGATGGCAGCGTGCGGGTACTGGAACGCGCCCCGCTCGACCTCCAGGTCGAACAGGGAGGCCCCCAACTCCGCCTCCAGGCGCCGCAGTCGGGCGTACCCGGCAGCCTGAATTTGGTCGGTCACGATCACGTCGATGTACTCACCAACCGGCTTGGCCAGCGTCCTCATGATCAGGACGCCGAACGTGCTCGCGTCCTGCTGCACGCTTACCAGCTTGCTCTGGTCGATGGCTGCCAGGGCGGCTTCCTGGCGCTCCCTCGACGGCGGCCTTTGCGAGGCTTCTTCCAGCGCGGAGAACAGACTCAGCTGTCTGGTTTCCTCGGCCGTGTCCGAAGCCCCCGTAACGACGATCACTTGTGCACTCCTCGTCGCCCGGCGCAGCGGTGCCGCGTCGGGCTGATCACTCAGTGCTCACAAAGTAACACCAGCCTCTGACAACACAGAAGTTCGTTTATGCCCCGCGCGAAAGTGACGTGCGCCACATCACCAACAGCTTGCACGGCGCGAAACCGACAGGTATGCCCACTTCAACTGCTACCCCGGGGAACAGAAGAGCCCCCCGGGTCCGGGAGGCTCGCGGTGTGAGTATTGACAAATTGACACGCTTGCTGTATTAGCTCCAGGGTTTGGAAGGTAGATCGAGGGCCTGCGCCAGGTCCCCCGGTGGCAACTCCTTGCCTTCCGGCCAGCGAATGACGCGCCGCCCATCAGCTTCGACGCGATGCACGAAGACCCACGGCCCCTCGGGATGCGCCCGGTCGAAGTCGAGCACCACGCCCTCCTCCCGGACCTTCCGCTCAAACAGCTCTGCCACATACCGCTGATTCACACTGAGCGTGGGATCGCCAAGCCTCCGGCGGAGGAAGACGTGCAGGCTTCGCGCCCGGCTTCGATCCGTGAACTGAACACGTCCCGTCTCCCCATTGGGCCACGCAGCCTCAAAAATCGCTGTGGCCGCATTCGCATAGGGATAGCGCTTAATCCCGAGATTATCCAAGCGCTTGGCGACAGCCTGCACAGTCACCCCGTACAGCTCGGCTATTTGTCGGTTCGACAGGCCATCGCGGTAATGCTTCAGAAGAATCGTGTCGTCTGGAAGCAGCCTCTTCATAGCTTTAACCGATCTGTCAACTCATTACCCGACCACTAGCCTGTCTGCGCCTCGACGGTACCTCTATCGAGGGCCACGGTTCAAGTCACACTGTCCCCTGAGTCAACTAGGTGTGACGTGCGTCTCAACCCCCTGCTTCAACATCCGAAGCGCCTCGGTTTGACACCGACATCATCAGTGAGAGAGCGAGAGAAGCGAGCGAACGAACCGAGGGGAACGCTCTCAACAGAGAGCATAGAACATAGATTCGAATCTTGACTCTCTCTTGACGCCTACTTCATCAGTTCATGATCATCTACATATCTAGTCGAAGTAGGACAGATAACTTATGACATCTTGTTGAAATTTTCACTTAGTCATTACAAGTCCTCCTGCTGAACGCCCTGTTGAGGCTCTTCGCCTCCGGGCAGGTCCAGGAGTCAGCGCCCCGGCTGCCAGACCAGCATCCAGCCGGGGCCACAGTCATGGCCTGCCGTCCCCGGGTAGCTACCAGGGCCGACGGGTCCAGGGATGCGGTGTGTGGAGTGCACAGGGAGCCAGTAGCCGGCCGGTAGCTCCGGCCCGCGAGCCCCTCCCAGGCGCCGGTTCGACCCCGGCCATCCCGGTCAACTTCCGAGGAGGGTGAAGCCGTGCCAAGGGCGCGATCAATCTGCCTGACAAGCGGCTGCACGACCCCCACCGTGCGCGACGGACGATGCGCCGAACACCAGCTCCGCCGGAGCTGGGAACGGACCTCTGCGCGCAACCTCTCACGGCCTGCGGACTGGTCGAAGCGGAAGGCAAAAATCCTCGTCCGCGACCGCTTCCGCTGTCAGTTCTGCGGCTCTCCCCGGAAACTCGAAGTGGATCACATAATTCCGGTTTCCCGAGGTGGCTCGTGGGAGCCAGACAACCTGTGGACATTGTGTCAGTCGTGCCATAAACGCAAGTCACACCACGACCGACAGAGCCGCTGAATCAGCACAGAATCACACCAAACTTGCGTTGGGCGCTGGGACGCACGGGGGCCTCTAAATCCCTCGCTCTGTACGGAGCTGGTCCGGTTCGATTCCGGGGCAACGCACTCACTCAGCCAGACACATGACGCTGGCATATGCATGCGGGTCGCTCCCGCAGGTCCAGGGGCCGTGAGGCGCGCTACCGGTCTCCCTGGGCGGTGTCCGTAGTTCAGCGGCCGAGAACTCCTCCCTTCAGGAGGTAACGCCGGTTCGAATCCGGCCGGACACACCGCCACACCTAGTTGTGGATTCATTCATTCACCCTTCCCCTGGAGGCCCACCCATGACTGCCGACCGCTGTTCCCGCCGATGCGACGAGGGGCCCTAGGCCGACTCCGGCTCGGTGCCGGCTCCCCGCCCGCCCCGGGCGCAGCAGCGGCGTGACTGGCACCAGGACGCGTTGTTCGAGCTGGAGGAGCTGGCCGACCTGTACGGGATCGACCTGGAGCGGGTGAGGCTGTGACCAGAGGACCCCGCCCGAAGCCCAACGCGGTCCGGCGCAACGCCCATCCCCACGCGCAGGAACTCGCCGCGGAGGCTCGTGAGGGCCGGCCCCTGCCGAAGGCGCTCGGGATCCAGACCAGCGGCGCACGCCGGTTCTGGCGGACGTGGGCCCGTGCACCGCAGACGGCCACATGGGTTGAGACCGACTGGGCTGAGCTGGAGATCACGGCGAAGCTGGTTGATGCCCTGTACATGGGCGATCTGAAGTTGGCGCCCGAGATCCGGCAGCGGGTAGCGAAGTGGGGCGCAACGGTTGAGGACCGTGCACGGCTCCGGATGTCCCTCAAGGATGAGGACCAGGACCAGGATGACGCTGGGCCGGAGTCCGCGGCGCCGGCCGCCTCCGACATGGACGAGGAGCTGTACCGGTTGCTCAACGGACCCTAACCGCCCATGAGATTGACGACGGGAGGAACCCCGACATGCAGACAGGCAACCTGCCCGATGGGGTTCCGTCCCCGCGGGAGTCCCTGGGTTACCAGGTGATCCGCTGGGCACAGCGGTAGATCGTCCACCCCGACGGCGAGCGCGCGGGCGAGCCCTGGCAGTTCACCCCCGAACAACTCAAGTTCGTGCTGTGGTTCTACGCCATCAATCCCGATGGCACCTGGCGCTACAGCGCTGGCACCCTGCGACGGGCGAAGGGCTGGGGCAAGACCCCGTTGCTCGCCGCCTTGGCCATTGTCGAGTTCATCGGCCCCTGCCGCTTCGACCGCTTCGACGCCTTCGGCCTGCCGGTCGCCAAGCGCGTTCCGCTGCCCACGGTGCAGATCGGTGCCACCGCGCTCGACCAAACGGACCAGACACTTGAGATGATCCGAGGGATGCTCTCGGAGTCTCCGGCCGAGAAAGAGTACGGGCTGGAGATCGGCAAGTCCGTGATCCAGTTCAAGTCTGGCAAGCCGGGGTCGATCCGGCCGAAGGCGACCGCTGGCCGCACCAATGAGGGCAACAGGCCGACGTTCGCCCTGCTTGATGAAGTACACCACTGGGTTGGGAGCAACGGCGGCCCCGACTTCTACCAGGTCATCAAGCGCAACGTAGAAAAGACGGCCTCCGCTGGCTCTCGCTGGGTGACCACGACCAACGCCTAGAACCCGAATGAAGATTCGGTCGCTCAGCAGATCCACGAGTCCGACATGGTTCGCCAGGGCTTCTGGCTGTACGACTGCCTTGAAGGCAACATCCAGCCGGACGAGCTGCGCGACGAAGCCAAGGTCCGCCAGGCGCTCACCGAGGCGTACGGTGACGCGACGTGGGCCGACATCGACGGCCTGACGCGCACCATCCTGCACGACCGCACGACGCCTGATTCGACGTACCTGCGCTTCTTCTTCAACGCCATCGCGGAGTCTTCCGACGGCTGGATGGTCCGCGCGGAGTGGCTGGCCTGTTACGACGACCAGGACCCCATCAAGCCGGGCGATCAAATAGCCGTGGGCTTCGATGGCTCGATCCGCGGAGACGCCACAGGGCTCGTGGGATGCAGGCTCCGGGACGGAAAACTCTTCGTCTTGGGGATCTGGGAAAACCCTCGGGACCCCAATAACCCTGACTGGGAAGTTGACGTCCTGGCGGTCGAGGCCGCAGTGCACCGAGCCTTCAAAACGTATCGCGTCCAGTGGTTCTACGGTGACCCGCCGTACTGGCAGGAGAACCTAGGCCGCTGGGCTCTCGAATACGGTGACGACTACGTATACGAATTCTGGACCAATAAGCCTACGCGCATGGTCCAGGCCGTTGAGAGGTTCCGCACCGCTTCCATGGTCCAAGACCTGAAGCACGACGGAGATGAAGACCTCACCCGGCACATTCTCAATGCGGTGACGCGTGAAGTCCCTCAGGGACTCCTGATCACCAAAGACTCTCCCCGTTCAAAGAAGAAGATCGACCTCGCGGTTTGTGCAGTCCTGGCTTTTGAGGCGCGAGCCGACGCAATCGCGGACGGGCGCCTCACGATCAAACGAAAAAGAGTTGTCGGGTTCTGAGAAGGGCCCCGGAAAGAAAGGGGCTTGATGGACGGCGGTAGCCTCGTCAGCACGACGCCGGCCGAGATGCCGGTAGGTATCGCGCCGAGCACACCTGAGCAGTGGGTTGACTAGCTGTATTCGAAGCTGGCCCGCCGCAAGGCGACCTACCAGATTTAGGGCCAGTATTACGACGGCCAGCATCAGCGCCTCATGTTCTCGCAGGCACGGCACTACAACCACTTCCACCAGACCTTCGAGAGCTGGCGAGACAACTTCTGCGGCTTGATCATCGACTCGGTGAACGAACGCCTCACCGTGGACGGTTTCCGGATGACTGACGAGCCGGATGCCGACAAGGATGCTCGGGACATCTGGCAGCGCAACTACATGGATGCCGAACACAACGCGGCTCAGCTCGACGCGATGATTCAGGGCGCCTCTTACGCGGTTGTGTGGTCGGACGACGACGACCAACCGACCATCACCATGGAGAGCGCTGAGAACGTTGTCGTCCAGTACAAACCAGGGTCCAGGCGTGAACTCGCTGCCGCGGCGAAGTTCTACTAGGACGACTGGGGCCGGGAATGGGTGAACCTCTGGCTTCCTGACGCTGTGTGGTCGTTCGCCAAAGGCTCTTTGGCGTGGGGAGAGGGGCAAGAAGGCCCTAATCCACTGGGGGTTGTTCCAGTGGTTCCGATCAGCAACCGGTCTCGGCTGCTGCGTGACCCGGTGAGTGATCTCCATGTCGTCATCCCGATCCAGGACGCCATCAACAAGACCGTTGCTGACGCTCTGGTGGCGTCGGAGTATGCGGCTTGGCCTCAGCGCTACGTCACCGGCCTGGAAATCGTGGAGGACGAGCACGGCAATCCGGTTGAGCCGTTCAAGGTCGCCGTGGACAAGCTGCTCCAGGCCGAGGACCCGCAAGCCAAGTTCGGTCAGTTCGAGGCCGCCGACCTCGGCAACTACGTGACGCTGGTGGAGATGCTGGTCCAGCACATGGCCAGCATTTCCCGGATCCCGTTCCATTACTTCCTCAATGGTGGCGTCGTCCCGTCCGGTGAGTCGATTACCGCTGCGGAGGCAGGTCTCATAGCCAAGACCCGTGAGCGCATGCTGCACTTCGGGGAGGCATGGGAAGAGGTGATGCGCCTTTGCTTCAAGGTGCTGGACGATCCCCGCTCAAAGGCGTATTCGGCAGAGACGATCTGGAAGGATCCGGAGAACCGCACGGAAGCACAGCACATGGACGCTCTGCTCAAGCTCCAGATGATCGGCGTTCCGAGGGACCAGTTGCTTTCCGATGCCGGGTACACGCCTCAGCAGATTGCGCGGTTCCAGGACATGAGGGAAGCCGATGCCAAGGCCGCAATGGAGTTGGCGAAGAAGTACCCGATGCCTGTCCCGGAACCGCCGGCCGGGCCCGTCGGCATGAGCAAGGCGGCCCAGCAGACAGCCGTGAAGCGCCCGCAGGGCAACAGCGGCAACCAGGCCCGCAAGTCGTGACCACGGCTCCCGAAACGGGAGCCCATACCGAAATGGTGATGTGAATGACTGACACGAACGACAACACTTCTTCTTCTTCCGCCGAGCAGTCCGCCCCCGGCGAGCAGGCTCCGACGATCGAGACTCTTCAGGCCGAGGTCGAGAAGTGGAAGAGCTTGAGCCGGAAGAACGAGGACAGGTTCAAGGCGACCAGCGCCGAGCTGGACCAGGTGCGCCAGGCGTCCATGACGGACGCGGAGAAGGCTATCGAGGCGGCGCGGGCGGAGGCGCGCAATGCGACTCTCGCCGAGGTCGGAACTCGGCTCGCCGAGGCTGAGCTACGGGCCCATGCCGCGACTGCCGGTGTCGAACTTCCTCCCGCCGAGTTCCTGAACCTTTCCCGGCTCGTCGGCTCTGACGGTTCCGTGGACAGCGACGCACTGACAAAGCTCATCGCGTCCCTCCCCAAGCGGAGCAACAAGCCCGTATACCGGCAGGATCTTGGGTTGGGGCGGCAGGGTGACCCGACCGCCGGCCAGCTCACCCGTGAAGAGGTTTCCCGCATGACCGGTCCGCAGATCATGGCTGCCCGCAAGGAGGGCAAGCTTGACGCTCTGATGACCGGCCAGTTCTAATACGTGAGGTAACATGGCAGGCTTTATCACTCAGCCCGGAACCGGCTACCAGGCCAATTCCGGCAACGTTTTCATCCCCGAAATCTGGACCGCTGAACTCCTCCAGGATCTTGAGGAAGAGCTGGTTCTGGCTTCGGCTCGGTTCACCAACCGGCAGTAGGAGGGCGAGTTCCGCCGGGAAGGTGATGTCGTCCACATCCCGCACTTCGTCAATGACCAGGTGCAGGACAAGGGGCTTGTCCCGGCGTACGGCACGATCGGTTCGCCCGACCACGCGTCCCTCCAGTACATCGATATGCGAGTCGCCAAGGGCTCATCTTTCCATATCGAAGTGGACGCGCTCCACCAGCTCCAGACCAGGGTCGGTATCGACCTGATGAGCAACCTCATTGCTCAGCGGGCTCGCGCCATCGCCATCAAGCTGGATGAGCTGGTCGCCAAGACCCTGCTCGCCGCAGTGAGCGGCAAGGATCTGAACGGCAATGCCGATGCGAATGCGGCGGTTTCCGGTCTGACTGCTCTCCATGGCCAGATTGACGAGATCACCGACGCGCCGACTGGCGACAACGTCACCCGGGTTGGGGGCAAGGAACGGCTGAGCGTCTATCACTACGTGGTGGCGATGCTGGAGAACCTGGATATCAAGTCGGCGCCGGCCGACCGGTTCCTGTTCATTTCCCCGCGCATGCGGTCACTGCTGCTGCGCGACCCGAACTTCATCCAGGCGCAGGTGTACGGCGGTTCGCCGGTCATCCCGAACGGCGCTTCGGCGATCGGCACCATTCTCGGTGTCCCGGTCACTGTGGCCAACGCGCTGGGTTCCCACACCCGGCCGAACAACCCGCTCATCAAGAAGGGCAACCAGGCGTTCCAGCCGGTTGACTTGTACATGGGTGCCACCGCGGCTACGTCGGTCGTTATTCCGTTCGCGCAGATGGAGGCGTACAAGCCGCAGCAGTCTTTCACCGACGCGATCAAGTCGCGCGTGATCTACGACGCGAAGGTCATCCGGCCGGAACAGCTCGTCGTGGCGCGCAACGTCGAGGCCGCCATTACCGCGCACAACGGCGCCAGCACGACCCCGGCCACGACCTGA

Protein sequences of DBSCAN-SWA_2

>NC_017586|1772638:1790879|1783693_1784191_-|WP_014142419.1|DBSCAN-SWA
MKRLLPDDTILLKHYRDGLSNRQIAELYGVTVQAVAKRLDNLGIKRYPYANAATAIFEAAWPNGETGRVQFTDRSRARSLHVFLRRRLGDPTLSVNQRYVAELFERKVREEGVVLDFDRAHPEGPWVFVHRVEADGRRVIRWPEGKELPPGDLAQALDLPSKPWS
>NC_017586|1772638:1790879|1778447_1779002_-|WP_014142408.1|DBSCAN-SWA
MLEGNHDERPRKYLASRAPALAAEDTFYRFETLLDFPAFDVKKAEPYYPLAPGWVAVHGHESPGMSQVAGATARLKAAKAGISIVMGHTHRLAIAPHTTGHNGKLRTIYGFEVGHLMDVRQAGYLKNGPANWQKGFGLFYVGKYNATPHAIPIEDDGSFVVEGQRYGEIKRGPRGKFISKGGKA
>NC_017586|1772638:1790879|1779256_1779448_-|WP_106433107.1|DBSCAN-SWA
MTLEEHARAIEAAIKAAYADGYELDNGDCSPIHAMDLNTVNDGWLGRYVEIDLPEPTYSRGAM
>NC_017586|1772638:1790879|1774603_1774786_-|WP_014142403.1|DBSCAN-SWA
MTEANRILVYGLENGGVDLWCAKCETQIASGGCACCDNNAVTAQDIATATTAHHCKESAP
>NC_017586|1772638:1790879|1777543_1778104_-|WP_014142406.1|DBSCAN-SWA
MTDLDWGQLSELAGKVAREIANKWCVVEVDDVKQEILLHAMEERRTLAEHAEDHEFIRKVFWNAGRRYAAKERAYRDLMDDQYYYTPDEVRTVLRTFVYTDDEIGDVVGKKDDLTRCVISDNIMPARLDAAAALPKLSNEYQELIQRLYVYGMPPVNDAERRRGYRAVDALALSMNRHIRTKRGAA
>NC_017586|1772638:1790879|1774983_1775493_-|WP_014142404.1|DBSCAN-SWA
MSYPDPFEDKSPWDVPSHQTTTAKKETAPMPETSRHLARFKIGFTLKAGSGYDAEWLTPTVYGDTAEDTARAGAALLNALKAEGLIDLTAKAADYTRSQFKGGAGGTGPKTFQNGKVVPKTPPAVAGDDCPHGRSLVEKANWAAMFCNGPEGGKCEPLWRQKDGGFKAK
>NC_017586|1772638:1790879|1778100_1778451_-|WP_157894813.1|DBSCAN-SWA
MSMWKGREYRSKMSGLSFFTVAEPFEHGGTEYVAYIGDEWASPQIAKCALFGVGGVFERVLSPKYQIEQKVEVYCCEGKIVGVASEPDRDGDFTYIVRYPDGSTELAWESAMKAVA
>NC_017586|1772638:1790879|1786832_1787681_+|WP_014142425.1|DBSCAN-SWA
MVRQGFWLYDCLEGNIQPDELRDEAKVRQALTEAYGDATWADIDGLTRTILHDRTTPDSTYLRFFFNAIAESSDGWMVRAEWLACYDDQDPIKPGDQIAVGFDGSIRGDATGLVGCRLRDGKLFVLGIWENPRDPNNPDWEVDVLAVEAAVHRAFKTYRVQWFYGDPPYWQENLGRWALEYGDDYVYEFWTNKPTRMVQAVERFRTASMVQDLKHDGDEDLTRHILNAVTREVPQGLLITKDSPRSKKKIDLAVCAVLAFEARADAIADGRLTIKRKRVVGF
>NC_017586|1772638:1790879|1785648_1786080_+|WP_014142422.1|DBSCAN-SWA
MTRGPRPKPNAVRRNAHPHAQELAAEAREGRPLPKALGIQTSGARRFWRTWARAPQTATWVETDWAELEITAKLVDALYMGDLKLAPEIRQRVAKWGATVEDRARLRMSLKDEDQDQDDAGPESAAPAASDMDEELYRLLNGP
>NC_017586|1772638:1790879|1789796_1789943_+|WP_157894815.1|DBSCAN-SWA
MAGFITQPGTGYQANSGNVFIPEIWTAELLQDLEEELVLASARFTNRQ
>NC_017586|1772638:1790879|1786265_1786787_+|WP_014142424.1|DBSCAN-SWA
MLWFYAINPDGTWRYSAGTLRRAKGWGKTPLLAALAIVEFIGPCRFDRFDAFGLPVAKRVPLPTVQIGATALDQTDQTLEMIRGMLSESPAEKEYGLEIGKSVIQFKSGKPGSIRPKATAGRTNEGNRPTFALLDEVHHWVGSNGGPDFYQVIKRNVEKTASAGSRWVTTTNA
>NC_017586|1772638:1790879|1787873_1788230_+|WP_014142426.1|portal|DBSCAN-SWA
MFSQARHYNHFHQTFESWRDNFCGLIIDSVNERLTVDGFRMTDEPDADKDARDIWQRNYMDAEHNAAQLDAMIQGASYAVVWSDDDDQPTITMESAENVVVQYKPGSRRELAAAAKFY
>NC_017586|1772638:1790879|1779444_1779870_-|WP_014142411.1|DBSCAN-SWA
MKLKFGLDDEVTICPPKGREYSFVLRERKGQTGTVADIDSRYFLPYEVMFPDGRRYMFAEDELMPASTEPSTEEEGIDHPGHYTWMPGGMEVIEITRHFSFVRGNALKYLMRAGRKGDELEDLKKARWYLDYEIESLKVAD
>NC_017586|1772638:1790879|1780389_1780773_-|WP_041824523.1|DBSCAN-SWA
MSSKPPIALVLKHYYGIQLRDRSGWQKILCPLHPETNPSASANTGFQRWACFVCDVSEDSYDVIQREEGFGFRQAQEFADSRFGTGSEDVPLAVQGESGRGVHEGSGAGRRRRPVSNRIRRFGSYWP
>NC_017586|1772638:1790879|1789213_1789783_+|WP_014142428.1|DBSCAN-SWA
MTDTNDNTSSSSAEQSAPGEQAPTIETLQAEVEKWKSLSRKNEDRFKATSAELDQVRQASMTDAEKAIEAARAEARNATLAEVGTRLAEAELRAHAATAGVELPPAEFLNLSRLVGSDGSVDSDALTKLIASLPKRSNKPVYRQDLGLGRQGDPTAGQLTREEVSRMTGPQIMAARKEGKLDALMTGQF
>NC_017586|1772638:1790879|1779866_1780376_-|WP_014142412.1|DBSCAN-SWA
MLVIPYLRPAGGEHGVATVRCRCIADECVKDEAGRYLAPLQKERHQGHGKYRSLPGDVPRLYNTMALIGSSPNVVVTEGEMDAMTWEAAGVPAVGYQGTSAWRAHFDPAFMGFRHVYHVADGDEPGIAAAEKRAAEMPNAKVIIPAPRHDSNSFAYEYGFDVLRERIGL
>NC_017586|1772638:1790879|1775537_1777547_-|WP_014142405.1|DBSCAN-SWA
MTAWRTETARTVYERTYSRELPSGELETWPQTVERVVDGNLALVDEQFIEPDERERLVELIETFKVLPAGRHLRGSGVTDYALNNCWAAGWDPARPEEHFTFTLLRLAEGGGVGANYSNRYFAEFPAVENALQVHIVCDPAHPDYTEMAEAGLLSGDYAYTWHVAYAVEDSREGWAAALADLIRTAHNPQVRHTDRVYDVSRLRRKGAALRSFGGTASGPAPFAELLIRTGEILADCAGFPLTGMDAMEIDHEIARCIVAGGVRRSARMSVMHWRDSQIEEFVRCKREQSEHWTTNISVEVDSEFITMAEAGDPAARKVLTTIAEGALRDGEPGFWNSSLSAVGEPDGTYTVNPCGEATLNQWEPCNLGSLNLAAFVEDGRPDWEELDEAHRLLTRYLVRATFAPVADRRSAEVIARNRRIGVGHTGLADYLAKQGIPYSQAAHHDHGLVAYDLQTYAAVVDRAAQEYAAQLRIPVPVKRRVVAPTGTISKLAGVSGEGIHAPYAGYFVRRIRFSLLDPAEAAQVEEYRRSGYHVEPCIYAANTAVVAIPTRDVLLDEVLEQAYEHAGQLDLDAMLSVQEMYQQCWADQAVSYTAVIDPDQYTVEDLAGVLLHYMPRLKGSTVFPESSRAQAPYERITAEEYERLTADLDHRAVDTSYDEDCTSGACPI
>NC_017586|1772638:1790879|1784871_1785147_+|WP_157894814.1|DBSCAN-SWA
MRDGRCAEHQLRRSWERTSARNLSRPADWSKRKAKILVRDRFRCQFCGSPRKLEVDHIIPVSRGGSWEPDNLWTLCQSCHKRKSHHDRQSR
>NC_017586|1772638:1790879|1779002_1779233_-|WP_014142409.1|DBSCAN-SWA
MQAPFEDKRALRNVLAFIGDYQPDEVIQIGDLVDYPAPSRWSAGTRAEFEGNVIRDSEYTKRNFLAPLREVYSGPV
>NC_017586|1772638:1790879|1788251_1789169_+|WP_078590657.1|portal|DBSCAN-SWA
MNLWLPDAVWSFAKGSLAWGEGQEGPNPLGVVPVVPISNRSRLLRDPVSDLHVVIPIQDAINKTVADALVASEYAAWPQRYVTGLEIVEDEHGNPVEPFKVAVDKLLQAEDPQAKFGQFEAADLGNYVTLVEMLVQHMASISRIPFHYFLNGGVVPSGESITAAEAGLIAKTRERMLHFGEAWEEVMRLCFKVLDDPRSKAYSAETIWKDPENRTEAQHMDALLKLQMIGVPRDQLLSDAGYTPQQIARFQDMREADAKAAMELAKKYPMPVPEPPAGPVGMSKAAQQTAVKRPQGNSGNQARKS
>NC_017586|1772638:1790879|1790003_1790879_+|WP_014142429.1|DBSCAN-SWA
MQDKGLVPAYGTIGSPDHASLQYIDMRVAKGSSFHIEVDALHQLQTRVGIDLMSNLIAQRARAIAIKLDELVAKTLLAAVSGKDLNGNADANAAVSGLTALHGQIDEITDAPTGDNVTRVGGKERLSVYHYVVAMLENLDIKSAPADRFLFISPRMRSLLLRDPNFIQAQVYGGSPVIPNGASAIGTILGVPVTVANALGSHTRPNNPLIKKGNQAFQPVDLYMGATAATSVVIPFAQMEAYKPQQSFTDAIKSRVIYDAKVIRPEQLVVARNVEAAITAHNGASTTPATT
>NC_017586|1772638:1790879|1781388_1782207_-|WP_014142416.1|DBSCAN-SWA
MYSLTQSVEVKGSAGEPIPNPFAGLRRQEVEFRRGELSLVAAGPGTGKSLFAINLALFGNLPVLYFSADSNAATQLTRATAILTGDNVREVKRKLIADEFGEYHAALGERWWIRFNYEARPTPGDIEQDLACYYEVFGIYPYLIVVDNITNVDGGDGQADAGNFSFGLEAMCEYLSEMARDTQAHVLGLHHVVGEFSDGLRPIPLSGVKGKIGRVPSVILTIHKEIDGMDGRLLHVSPVKNREGFEDSSGQTFTTYEFNSANMRLTDLESEF
>NC_017586|1772638:1790879|1782232_1783021_-|WP_042507623.1|DBSCAN-SWA
MSVETQPRSVSQVQQYEECGWRYYLARVERVTPRPAAWSFHGSAFHAVAEAVVLSNGRMTAEEAVEAFSDKYARLVQDALDIEPDTDRWLSSGRYSGGEEIERRYVLGQEQTAQYVDWVAEHRPEVWTTPAGKPAVELGFTVELGGVVVRGIIDLLVMEADGDAVRVRDLKTGSIKSRFQLETYAVAIESLYDVPVRRGDWYLAKDGRLSRPVALDQVSPAEVGERYATMDAGVKAGRFEANPGYGCRFCDVSHGCFFYATS
>NC_017586|1772638:1790879|1772638_1774435_-|WP_014142401.1|DBSCAN-SWA
MKHLHYKIKHQQVRINVVETTDDIREFDRWLGKNPVLGFDTETTGLNWWDWDRGFRLRLAQFGNGSESYVIPVELGEPYRRAAQRALLGAGTLIAHNAIFDQHVIEASLGIPLEVLAPKTICTKITAHLVDPRGVKEKGPGLKLEELTKHYIDPVVAEEVKGSMVLLARKYKTTKHKIWPIVELFDEDFLLYAGMDPILAYRLFHILWPLVPARTKRRGLFSWEHRLNHVTGLIERTGYLLDSDYAEARLAELAAEYERWEQVANRYGVENINSTAQLVDAFLGFGIRLTKKTAKGNLAMDDDVLNGIDHPLAEAVIKARRARKWSATWFQRALDGRDSRGRVHASINSIQARTARMSITGSVPAQTFPAGDGYVRHMFLAEEGHVSVSIDFGNMELRDLAAFSQDPTMLHAFANGLDLHQITADAAGVPRKVGKGANFLTVFGGGWRAMVEQFGVDEETAKRTLSAFADTYPRVGVLAKQLADEARRTGFVYTPTGRRLPVDRGRAYAALNYFIQSGSRDITARALLRLADAGFAPYMRLPIHDEILFSFPRDAAAELTREAARLMEFTIRGVLIPAEGEIGDRSWGSVLELEESKH
>NC_017586|1772638:1790879|1783026_1783434_-|WP_014142418.1|DBSCAN-SWA
MIVVTGASDTAEETRQLSLFSALEEASQRPPSRERQEAALAAIDQSKLVSVQQDASTFGVLIMRTLAKPVGEYIDVIVTDQIQAAGYARLRRLEAELGASLFDLEVERGAFQYPHAAILGSRFFEFIRVSKVVMG
>NC_017586|1772638:1790879|1780905_1781316_-|WP_014142415.1|DBSCAN-SWA
MVTTAKANKDKGYRWEKQALDHIRAAFPEIDPEEIRRHGTLYGVNDRGDITLAPLAFVFEMKNVQRFDLARFMRELKRELEHNPQATNGAVVIKARLKGTGEAYSVMPFDSLLSLVRENWDLKRLLRQERQLRKAG

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014142401.1|1772638_1774435_-	DNA polymerase	A0A220NQB6	Rhodococcus_phage	1.7e-162	51.5
WP_014142403.1|1774603_1774786_-	hypothetical protein	NA	NA	NA	NA
WP_014142404.1|1774983_1775493_-	hypothetical protein	NA	NA	NA	NA
WP_014142405.1|1775537_1777547_-	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent	A0A0N9RS78	Mycobacterium_phage	9.0e-208	55.6
WP_014142406.1|1777543_1778104_-	hypothetical protein	NA	NA	NA	NA
WP_157894813.1|1778100_1778451_-	hypothetical protein	NA	NA	NA	NA
WP_014142408.1|1778447_1779002_-	hypothetical protein	A0A2P1JTH8	Mycobacterium_phage	1.6e-37	51.2
WP_014142409.1|1779002_1779233_-	hypothetical protein	I6WID8	Mycobacteriophage	1.7e-25	69.3
WP_106433107.1|1779256_1779448_-	hypothetical protein	NA	NA	NA	NA
WP_014142411.1|1779444_1779870_-	DUF3310 domain-containing protein	G9FHE1	Rhodococcus_phage	1.4e-14	33.1
WP_014142412.1|1779866_1780376_-	toprim domain-containing protein	A0A088FWB0	Mycobacterium_phage	1.0e-30	44.6
WP_041824523.1|1780389_1780773_-	hypothetical protein	NA	NA	NA	NA
WP_014142415.1|1780905_1781316_-	hypothetical protein	NA	NA	NA	NA
WP_014142416.1|1781388_1782207_-	AAA family ATPase	A0A2K9VI58	Mycobacterium_phage	6.1e-62	47.2
WP_042507623.1|1782232_1783021_-	PD-(D/E)XK nuclease family protein	A0A0K1LJJ9	Mycobacterium_phage	1.5e-46	41.0
WP_014142418.1|1783026_1783434_-	hypothetical protein	NA	NA	NA	NA
WP_014142419.1|1783693_1784191_-	hypothetical protein	NA	NA	NA	NA
WP_157894814.1|1784871_1785147_+	hypothetical protein	H6WG01	Cyanophage	1.3e-08	50.0
WP_014142422.1|1785648_1786080_+	hypothetical protein	A0A2P1CID7	Actinomyces_phage	1.8e-09	52.5
WP_014142424.1|1786265_1786787_+	hypothetical protein	A0A2H4J271	uncultured_Caudovirales_phage	2.3e-30	38.2
WP_014142425.1|1786832_1787681_+	hypothetical protein	A0A1B3AY92	Gordonia_phage	2.2e-51	37.1
WP_014142426.1|1787873_1788230_+|portal	phage portal protein	A0A291AUY2	Mycobacterium_phage	4.1e-07	33.0
WP_078590657.1|1788251_1789169_+|portal	phage portal protein	A0A1B1IN58	uncultured_Mediterranean_phage	1.8e-30	31.3
WP_014142428.1|1789213_1789783_+	hypothetical protein	NA	NA	NA	NA
WP_157894815.1|1789796_1789943_+	hypothetical protein	NA	NA	NA	NA
WP_014142429.1|1790003_1790879_+	hypothetical protein	D7NW53	Streptomyces_phage	6.8e-11	29.6

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NC_017586|1797771:1804327|DBSCAN-SWA
CATCCAGGTCGAGTCCGGCGGCAACCCGAACGCCATCAATTTGTGGGACAGCAACGCCCTGGCCGGCATGCCGAGTCAGGGGCTCATGCAGACGATCCCGCCCACGTTCGACGCCTACGCCGGTCCGTACCGCAGTCTCGGGATCACCAACCCTCTGGCCAGCATCTATGCCGGTCTCAACTACGCGATCCACCGCTAGGGCGCCGGCTGGGTGCAGGCCCTCGCCGGCACCGCCGGGTACGCCTCAGGCACCTCGGGGGCACGGCCCGGCTGGGCCTGGGTCGGCGAGGAAGGCCCCGAACTCGTCCGGTTCGGCGGCGGGGAGACGGTGCTGAACCACCGGGACTCGATGCGGGCCGCAACCCGTGGCCTGCCCGGGTACGCCTCGGGCACGAAGTCGGGCGTGGCCGTCGACGCGGAGAAGGGCGCGTCCTCGCTGAGTGCTGCGGTGAAGCGGCTCTACGAGATCATCACCAAGGCGTTCACGTCCGGGCGGATCGGCCAGGGCACGGAGAATTCGCTGAACCGCTGGCTCGACGGTGAGAACAAGGCACTGTCGAACCTGGTGAAGCAGCGGACCGACCTGGCGGGGAAGCTGAAAGCGGCTCAGGCCGCGTTGAAGAAGGTCAAGGACGACGAGGCGAAAATGGCCTCGGGGATCTCCGACAAGGCATCGTCCCTGCGCGACCTGTCATCGGTTTTCAATTCCGATGGCGTGTCGGTGACTGCTGGTCTGTCCGGGCTCCACGAGCGCCTGGCCGCCATCAAGAAGTTCCAGGCCAACCTGAACACCTTGGTGAAGCGGGGTTTCTCGTCGGCAATCATCGAGAACATCGCGGAGGCCGGTCCGGAACAGGGCGGGGCCATGGCTCAGGAACTCCTGAACGCCACCGGCGCCCAGATCAAGGACTACAACAAGACGTACGCAGCCATCGGCACGGCGTCCGATTCCCTCGGGAACTCGGTAGCCAAGTCCTACTACGCCACTGGCGAGAAGGCTGCTCAGCGTCTTGTCGATGGTCTGATGTCCAAGGACAAGGTATTGGTCAAGAAGATCGAGTCCCTTGCGGATTCGATCGTCCGGACGCTGAAGAGGACGCTGAATTTCGGCTCCACCACACCGGTGACCTCCGGTCTGGGTGCTCTGCTCACCTGGCTCACCGGCGAGTCGCAGAGCGTCGGGCGCAAGCCCAAGCCGAAGCCCAAGCCCAAGCCCAAGCCGACGCCGCAGGTCAAGCGCACGGTCACGACCACGACGGGATACGACTCCAAGGGGCGGTCCGTCACCACGGTGACGACGACCATCACGGATCCGTGGGCCGGTACGACCACCACCATCACGGAGCGGACCGTCGACGGGCGGACGACCACCACCCGATCCGTCCGCAGGACGACCAAGGGCTACGCCACCGGCACTCTTTCCGCCTCGCCGGGTATGGCGCTGGTCGGTGAACGCGGCCCGGAACTCGTGGACTTCCGCGGAGGCGAGCGCGTCTACACCGCACGGCAGACGGCCGACCTGATGGGGCCTCGCTACGAGATCCACATTCATGAAGCGAAGGCGGAGAACACCACGCAGGCCGTTCTCCGCGCGCTGAAGTACGCGGAGGTGATGTCAGGAATGTAAAAGCGAAAGGAGTGCTCCATGCCGATTCCCGCAGCGGTCACGTCCCCCAACGATGCCTGGTCGGGGGATTTAACCGTCCCCGTTCCGGTGGAGTGGCAGAGCACCTACGTATCGATCCGAGGGAACAACGGTCAGGGGGAGGAAATCCCCCTGACCGGTTTCCTGTCCGCGGCATGGCCGGCCATCATGCTCCAGCCCGGGGCAACCGGGCTGGACATGCCCCCGTTCGAAATCCACGCCGACGACTCCCCGAACCTGGACGGCTCGATGTACCGGGGAGCACGGGCAGCGGCGCGGGACATCCTGCTACCGCTCTACGTCTACGGCATCGACCGCCTGACGCTGCGCCAGTTCAAGAGGGATCTCGCCAACGCGCTCAACCCCAAGTCGGGTTACTGCGTGCTGACGTTCATCGAATCGGACGGCATTCCGCGAAGGCTGCGCTGCTACTACAAGGGCGGCATGGAGGGGAGCGAGGCCGCCGACTCGGCCGGGTTCCGCTGGGTGTCCTACGGAATTCAGCTCACCGCCATGGACCCCTGGTTCTACGGAGACACACAGGTCGTGGCGAGCTGGTCATTCGGCAAGCCCCAACCCTTCCTCGGCAAGTTCCTTCCGTTGCGGCTGGGCAAGGGCACGCTGGCTACCAACACCCTCCAGGTCAGCAACCCTGGGGACATCGAGGCGTGGCCGGTGTGGCGGATCTCCGGGCCGGTCAAGTCCCTGATCCTCACGGGCCCCGACGGCTCTTCCTGGGGAATTCCGGCGCAGGCCAGCGGAGCGGACGTGATCCCTATCGGGCGCACGCTCACGGTGGACTGCCGTCCCGGCTACAAGACCGTGACCGATGACCAGGGGAAGAATTATTTCCCGCTGCTTGCAGCGAATCCGTCGCTGTGGCCGGTGCCTCCGGGAACGTCAACGGTCGCTACGAATCTGGTGGCCGGCAGCGGCACCGCGGCCGTGACGATGACGCTGGATCCCCGCTACGCGAGTTACTGACGAGGTGCACTGATGGGTTACCGGGTGGAGGTGCGCGACGCCGCTCTCAACCGCATTGGAGTGATCGACACATGGATTAAATTGGATCTGGTGGTGCGTTACTGCCAGACCGGTTCCTGGCAGGTTCTCGTGGAGGCGGGAACACCGCAGGCGGACCTTCTCCAGAAGGGCGGCGGAGTCGCCATCTACCAGGACGGGGTGAAAGACCCGGTTCTCACTGGGCAGATCGAGGCGTTCCAGCATTACTGGACCAATGATCAGCACACCTCGCTCGGCTCCCTGTATTTCGGGGGGAAGTGCGACAACAAGCTTGCCTACAACCGGCTTGCGTTCCCGGACCCGGCCAAGGACGCCACGCAGCAGTGGCAGGCCGACGACACCCGCAAGGTCAAGGGCCCGGCCGGCCAGCTCATCTGGTCGGAGCTGAACCAGGCCCTCGGGCCCGGGGCGCTGCCCAGCCGGCAGATTCCCGGGGTCGTGATCGGCAGCAACGTCCCCAGTGGCCCCACGCTTTCGGACAACCTCCGATGGGATGTGATCGGGACCAAACTCGAATCGTGGATCGACACGAAGACGACCGGTTACCGGTTCCTGTACGACCCCAACGCCAAAGCGATCAACTTCCACCCCTTCACGCCCCGTGACCTCTCGCAGGACATCCGGTTCAGCACCGAGCTGGGCAACCTGCGGGAATTCACGTGGGCGCTCACCGCGCCGACGGTGACACGGGTGATCGTGGCGTGCCAGGGCGCAGGGAAGTCACGCTACCTCTATCAGCAGACCGACACCGCCAGCGAAGCCGAATGGGGGCTCCAGATTGAACAGTTCCTCGACCGCCGCGACCTACCCATCAAGGCGGACCCGACGACAGGACAGCCGATCAAAGCCGATCTTTCCGTTTCCGACACCGACTTCCAGACCGCACTCCAAGCCGTCAAGGACGCGGCCAATGAGGCGCTGACCAACGGCGCCAAGAACGGCAACTTCCAGATTTACCCCATCGACACCGATCACGTGAAGTTCGGCCGTGATTACTTCGTCGGGGACATCGTGACAGTTGCCGTGGACGGCACCGAATACGTGGACATCGTCCGTGAGGTCTCCATCACAGTGGAGCAGGGCGGCCAGACGGAAACCGTCGCCCCCTCGATCGGGGAGCAGGGATCCGGCAACCCGCTGAATCTCTACAAGACGGTATTCGAGATGCGCGAGAAACTGCGCAGGCTAGAGGCAAGGATGTAAATGGGAAACGAGATCAGCTACCCGTTCAGCTCGGACTCCGCCGGTGGCGGACAGCAGATGGTGTCCCAGGCGCAGTGGCAGATGATGAGCCGCATGTTCGGGCCGGACCGCATCGACACCCAGCTCGTCAGCAGCAGCTACGACGGTTCAGCCCTCCCGTTCGCGGCCTCCGTCGTCAACGGCACGTCAGTCTCCGTCTCCCCCGGCCGCGCGCTGGTCGGGGGCTTCTACTACCAGCTCACCGCAGCCCAGAGTGTGGCCATCGCCGCCAACACCGGGACGAACCCCCGCGTCGACCTCATCGTGCTCCGGGCCGACCTGGCGGCCGGCTCGGTGAACCTCGCCGTCGTCCAGGGCCAGGCCGCGGCCTCCCCGGTCGTGCCGCAGCCCACACGCACACTCGGCGGCCGGTGGGAGCTGCCCCTGCACCAGGTCACCGTACCCGGCAACAACGGCACTCTCAGCGTCCTGTCAGTGGGCCCGTTCGACATGCCGTCACCCGTCGCCGTGCCGTGGAACGCGTCGCAGCTCGCCCAGGTGACACCGGTCGGCACGTACATCTACGACCTGGACAGCAACACCAACGACACCCAAAGCGAGTATTTCGTTGGCCGGGACGGTGTTGCTGTGACCCGGCACCTGGGCAAGGCACGCCCGTACACCCCGAGCCTGGTCAACGCTACGGATCCGCTGCCGACTTCCTACCGCACGGGCCGGTGGCGCATCATCGCGCCGGGCATGGTCTGGTTCGCCGTGACCATCAACAACCAGAACGACGGCGGCGCAATGCTCAGCGGGAAGAACTGGATCATGGGAATCACCCTGCCTCCGGTCCCGGCGGCAACAGCGACCCGCCAGGTACTCCACGGGCACATCACCAACGCACGCGGCGGCGGCAACCTGCCCAACTACATGTCTGTTACCGCACTGATCGAACAGGGCGGCACCGGGCAGACCACCGCCTACCTGTACTACCCCAGTCCGACCACCCCCGCCCAGGGCCTCGACGCACTGCCCGGGATCCCCGCCGGAGCCATCCTCACCCTGTCCGGGGTGTACCAGACCAACGTCTACGGAGACTGAATCATGCGACAACTCTTCGGCGGGACAGCGTCCGACTTCGCCGAGGACGCCGCCGGCACCCGCGTACCCGGCGCCATCGGAACCGTCTGGGACGGGCCGAGCACGGGCGCACAGCAGTACACCGACCTCACCACCGCTGATGGCGCCCCGATGTACCAGCTCACTGCCGACTCACGGGGGTTCGTCCCGGCCTTCTTCGGCCCGGATGGCGTCGAGAGGCTGTGGGTCGATTTCGGGGCCGGCCGCGTCGCGCTGACCTCCGTGACCGTCGGCGAACGCCTCGACGCCCACACCAGCGCCCTCGACCCGCACGGCGACCGCGCCTACGCGGATGGCGCCTTCCTCAAGAACAGCGGCAACGGCCTCGAAGTCACACCGGACGGAAAGGCCATCGTCAGCCACGTTCCCCACCAGTTCACCGGACCTCTGCGGCTCTGCTCGGCGAGCGGGGATCTCCTCGGGGAGCTGTACGCCGAGGGCGGCGCGCTGAAGTGGCGCAGCTCCGCAGGCACCGTGACCACGATCGCCCCGGCGTAAGGAGACTGCTCGTTGACCCCTCAGACCATCACCAACTAGGCCAGCATCGCAGCAACAACCATCGCTGCCCTCATTTCCCTCGCCGCGGCCGTGAAGTACCACACCGGCCGCGTCTGGCAGGCCGAGGCGGAAGCTCAGAAGGCACGAGCCGACCGGCTCCAGGACGACCTGGCGGAGATCAAGGAACGCCTCGCTCGGATTGAGGCCGAGAACTCTCGGCTTCTGGAGATCCTGTCCGTCATCGACCCTGAACGCATCGCCGCCCTGCGGCATCCCTGACCCCAGCAACTTCCCTGCGGGCCGCCCACACCGGGCGGCCCTTCCTCATACCTAGGAGAACACCTTGATCAAGGGCATCGACGTTTCCTCGTACCAGTCCACCGACTTCGACACTGACGGCCTCGACTTCGTCTTCATCAAGGCCACCGAGGGCACCTCGTACGTCAACCCGCGCATGGCCGGCCAGGCGGCCACCGCCCGCGCCGCCGGCCTGGTGGTCGGCTTCTACCACTACATCTCACCGGGCGACATGTCCGCGCAGGCCGCCTTCTTCGTGGACCGGTGCGACTCCGTACCGGGCGACGTCCTGTTCGCCGACTGGGAAGAGCCGGGCGTGTCCTGCGCTCAGAAGGACCAGTTCATCCGCGAGGTGAAGCGCCTGCGCGGCTCGAACCACAAGGTCGGCCTGTACTGCAACCAGGACTACTGGCTCAACCGCGACTCCAGCTCGTACGCCGGTGACGCCCTCTGGATCGCCGACTACGTAACCCCGGGGCGCCCGCGCATCCAGGCGAACTGGCTCTTCCACCAGTACACCGACCGCCCGTTGGACACCAACGTGGCCAGCTTCGCCAACCGCGCGGCGCTGCGCTCATGGGCGGGCGGCAGCTCGGCGCCGGCCCCGAAGCCGACCCCGGGACCGGTCACGTACACGGTCCGCTCCGGCGACACCCTCTCCGGCATCGCGCAGAAGTACGGCACCACCGTGGCGAAGTTGTCGGCGGCCAACGGCATCAAGGACCCGGACATGATCTTCGCCGGTCAGGTTCTCAAAATCGTGAAGTGA

Protein sequences of DBSCAN-SWA_3

>NC_017586|1797771:1804327|1800411_1801641_+|WP_014142444.1|DBSCAN-SWA
MGYRVEVRDAALNRIGVIDTWIKLDLVVRYCQTGSWQVLVEAGTPQADLLQKGGGVAIYQDGVKDPVLTGQIEAFQHYWTNDQHTSLGSLYFGGKCDNKLAYNRLAFPDPAKDATQQWQADDTRKVKGPAGQLIWSELNQALGPGALPSRQIPGVVIGSNVPSGPTLSDNLRWDVIGTKLESWIDTKTTGYRFLYDPNAKAINFHPFTPRDLSQDIRFSTELGNLREFTWALTAPTVTRVIVACQGAGKSRYLYQQTDTASEAEWGLQIEQFLDRRDLPIKADPTTGQPIKADLSVSDTDFQTALQAVKDAANEALTNGAKNGNFQIYPIDTDHVKFGRDYFVGDIVTVAVDGTEYVDIVREVSITVEQGGQTETVAPSIGEQGSGNPLNLYKTVFEMREKLRRLEARM
>NC_017586|1797771:1804327|1797981_1799397_+|WP_014142442.1|DBSCAN-SWA
MQALAGTAGYASGTSGARPGWAWVGEEGPELVRFGGGETVLNHRDSMRAATRGLPGYASGTKSGVAVDAEKGASSLSAAVKRLYEIITKAFTSGRIGQGTENSLNRWLDGENKALSNLVKQRTDLAGKLKAAQAALKKVKDDEAKMASGISDKASSLRDLSSVFNSDGVSVTAGLSGLHERLAAIKKFQANLNTLVKRGFSSAIIENIAEAGPEQGGAMAQELLNATGAQIKDYNKTYAAIGTASDSLGNSVAKSYYATGEKAAQRLVDGLMSKDKVLVKKIESLADSIVRTLKRTLNFGSTTPVTSGLGALLTWLTGESQSVGRKPKPKPKPKPKPTPQVKRTVTTTTGYDSKGRSVTTVTTTITDPWAGTTTTITERTVDGRTTTTRSVRRTTKGYATGTLSASPGMALVGERGPELVDFRGGERVYTARQTADLMGPRYEIHIHEAKAENTTQAVLRALKYAEVMSGM
>NC_017586|1797771:1804327|1801641_1802724_+|WP_014142445.1|DBSCAN-SWA
MGNEISYPFSSDSAGGGQQMVSQAQWQMMSRMFGPDRIDTQLVSSSYDGSALPFAASVVNGTSVSVSPGRALVGGFYYQLTAAQSVAIAANTGTNPRVDLIVLRADLAAGSVNLAVVQGQAAASPVVPQPTRTLGGRWELPLHQVTVPGNNGTLSVLSVGPFDMPSPVAVPWNASQLAQVTPVGTYIYDLDSNTNDTQSEYFVGRDGVAVTRHLGKARPYTPSLVNATDPLPTSYRTGRWRIIAPGMVWFAVTINNQNDGGAMLSGKNWIMGITLPPVPAATATRQVLHGHITNARGGGNLPNYMSVTALIEQGGTGQTTAYLYYPSPTTPAQGLDALPGIPAGAILTLSGVYQTNVYGD
>NC_017586|1797771:1804327|1797771_1797969_+|WP_078590659.1|DBSCAN-SWA
MQVESGGNPNAINLWDSNALAGMPSQGLMQTIPPTFDAYAGPYRSLGITNPLASIYAGLNYAIHR
>NC_017586|1797771:1804327|1799415_1800399_+|WP_014142443.1|tail|DBSCAN-SWA
MPIPAAVTSPNDAWSGDLTVPVPVEWQSTYVSIRGNNGQGEEIPLTGFLSAAWPAIMLQPGATGLDMPPFEIHADDSPNLDGSMYRGARAAARDILLPLYVYGIDRLTLRQFKRDLANALNPKSGYCVLTFIESDGIPRRLRCYYKGGMEGSEAADSAGFRWVSYGIQLTAMDPWFYGDTQVVASWSFGKPQPFLGKFLPLRLGKGTLATNTLQVSNPGDIEAWPVWRISGPVKSLILTGPDGSSWGIPAQASGADVIPIGRTLTVDCRPGYKTVTDDQGKNYFPLLAANPSLWPVPPGTSTVATNLVAGSGTAAVTMTLDPRYASY
>NC_017586|1797771:1804327|1803351_1803540_+|WP_014142447.1|DBSCAN-SWA
MKYHTGRVWQAEAEAQKARADRLQDDLAEIKERLARIEAENSRLLEILSVIDPERIAALRHP
>NC_017586|1797771:1804327|1802727_1803261_+|WP_014142446.1|DBSCAN-SWA
MRQLFGGTASDFAEDAAGTRVPGAIGTVWDGPSTGAQQYTDLTTADGAPMYQLTADSRGFVPAFFGPDGVERLWVDFGAGRVALTSVTVGERLDAHTSALDPHGDRAYADGAFLKNSGNGLEVTPDGKAIVSHVPHQFTGPLRLCSASGDLLGELYAEGGALKWRSSAGTVTTIAPA
>NC_017586|1797771:1804327|1803604_1804327_+|WP_014142448.1|DBSCAN-SWA
MIKGIDVSSYQSTDFDTDGLDFVFIKATEGTSYVNPRMAGQAATARAAGLVVGFYHYISPGDMSAQAAFFVDRCDSVPGDVLFADWEEPGVSCAQKDQFIREVKRLRGSNHKVGLYCNQDYWLNRDSSSYAGDALWIADYVTPGRPRIQANWLFHQYTDRPLDTNVASFANRAALRSWAGGSSAPAPKPTPGPVTYTVRSGDTLSGIAQKYGTTVAKLSAANGIKDPDMIFAGQVLKIVK

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_078590659.1|1797771_1797969_+	transglycosylase SLT domain-containing protein	A0A142K904	Gordonia_phage	7.3e-14	63.9
WP_014142442.1|1797981_1799397_+	hypothetical protein	A0A2H5BLG0	Streptomyces_phage	1.3e-11	33.1
WP_014142443.1|1799415_1800399_+|tail	phage tail family protein	A0A0E3DJL1	Propionibacterium_phage	9.3e-17	25.2
WP_014142444.1|1800411_1801641_+	hypothetical protein	A0A291LHA1	Streptomyces_phage	3.3e-27	29.0
WP_014142445.1|1801641_1802724_+	hypothetical protein	A0A0K0N633	Gordonia_phage	1.2e-09	30.2
WP_014142446.1|1802727_1803261_+	hypothetical protein	NA	NA	NA	NA
WP_014142447.1|1803351_1803540_+	hypothetical protein	NA	NA	NA	NA
WP_014142448.1|1803604_1804327_+	LysM peptidoglycan-binding domain-containing protein	Q8LTJ6	Lactococcus_phage	9.3e-14	30.8

2. NC_017585

CRISPR-Cas detection and classification

Crispr_ID: NC_017585_1

• CRISPR_ID: NC_017585_1
• CRISPR_location: 914060-914167
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_017585_1

Consensus_repeat	Method
CCGGCCCCGCGCCGCTACGCTGAC	CRISPRCasFinder

spacers of NC_017585_1

>1.1|914084|60|NC_017585|CRISPRCasFinder
GACACCATCACCGTTGCGGATCGCCTCGTTCCGTCGCCGGTCAACTGGCACCGTTGGCCC

CRISPR arrays and Neighbor proteins around NC_017585_1

CRISPR arrays

The CRISPR arrays of NC_017585_1

>merge|NC_017585|1|914060-914167|CRISPRCasFinder
CCGGCCCCGCGCCGCTACGCTGACGACACCATCACCGTTGCGGATCGCCTCGTTCCGTCGCCGGTCAACTGGCACCGTTGGCCCCGCGCCCCGCGCCGCTACGCTGAC

>NC_017585|1|1|914060-914167|CRISPRCasFinder
CCGGCCCCGCGCCGCTACGCTGAC	GACACCATCACCGTTGCGGATCGCCTCGTTCCGTCGCCGGTCAACTGGCACCGTTGGCCC
CGCGCCCCGCGCCGCTACGCTGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017585.1|WP_014151276.1|906572_907664_-|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|223677
NC_017585.1|WP_014151258.1|923191_923599_-|hypothetical-protein	unknown	unknown	unknown
NC_017585.1|WP_014151263.1|918213_918858_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl|CDD|274422
NC_017585.1|WP_014151273.1|909889_910669_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|180604
NC_017585.1|WP_014151264.1|917587_918127_+|hypothetical-protein	unknown	unknown	unknown
NC_017585.1|WP_014151260.1|921777_922716_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|366166
NC_017585.1|WP_014151271.1|911857_912766_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197775
NC_017585.1|WP_014151278.1|904469_905453_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_017585.1|WP_041823648.1|920448_921717_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_017585.1|WP_014151270.1|912775_913390_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_017585.1|WP_106433081.1|915555_916071_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_017585.1|WP_014151269.1|913611_913911_-|hypothetical-protein	unknown	unknown	unknown
NC_017585.1|WP_014151259.1|922935_923184_+|hypothetical-protein	unknown	unknown	unknown
NC_017585.1|WP_014151262.1|918940_920203_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
NC_017585.1|WP_014151277.1|905436_906255_-|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|119339
NC_017585.1|WP_014151257.1|923595_925572_-|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319849
NC_017585.1|WP_014151274.1|908676_909759_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_017585.1|WP_014151272.1|910684_911575_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|375319
NC_017585.1|WP_014151268.1|914196_914637_+|hypothetical-protein	unknown	unknown	gnl|CDD|380387
NC_017585.1|WP_014151275.1|907853_908483_-|LysE-family-translocator	unknown	unknown	gnl|CDD|224199

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017585.1|WP_014151276.1|906572_907664_-|zinc-binding-alcohol-dehydrogenase-family-protein	gnl|CDD|223677	COG0604, Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only].	8.27513e-57
NC_017585.1|WP_014151263.1|918213_918858_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl|CDD|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	3.50229e-17
NC_017585.1|WP_014151273.1|909889_910669_+|SDR-family-oxidoreductase	gnl|CDD|180604	PRK06523, PRK06523, short chain dehydrogenase; Provisional.	1.13177e-72
NC_017585.1|WP_014151260.1|921777_922716_-|alpha/beta-fold-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	7.55385e-19
NC_017585.1|WP_014151271.1|911857_912766_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	2.42221e-09
NC_017585.1|WP_014151278.1|904469_905453_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.00857e-09
NC_017585.1|WP_041823648.1|920448_921717_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.59634e-75
NC_017585.1|WP_106433081.1|915555_916071_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	3.86086e-16
NC_017585.1|WP_014151270.1|912775_913390_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.7826e-13
NC_017585.1|WP_014151257.1|923595_925572_-|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319849	cd07551, P-type_ATPase_HM_ZosA_PfeT-like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron. Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_017585.1|WP_014151262.1|918940_920203_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	8.52117e-87
NC_017585.1|WP_014151277.1|905436_906255_-|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	8.5613e-47
NC_017585.1|WP_014151274.1|908676_909759_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.82506e-12
NC_017585.1|WP_014151272.1|910684_911575_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.8629e-07
NC_017585.1|WP_014151268.1|914196_914637_+|hypothetical-protein	gnl|CDD|380387	cd06982, cupin_BauB-like, Pseudomonas aeruginosa BauB and related proteins, cupin domain. This family includes bacterial proteins homologous to beta-alanine degradation protein BauB from Pseudomonas aeruginosa, which is involved in the degradation of beta-alanine. Also included are Rhodopseudomonas palustris Rpa4178 and Bordetella pertussis Bp2299, which are both proteins with unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.64261e-08
NC_017585.1|WP_014151275.1|907853_908483_-|LysE-family-translocator	gnl|CDD|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.93381e-36

Protein sequences

>NC_017585.1|WP_014151269.1|913611_913911_-|hypothetical-protein
MHLLARLLAGTALAACVTVVVVPAWTAPGAPAASGARCGGLSGPRRGVGYDNCAAHAVRIRVGHYVGVGDDYVCVPAFGRYRAPGWNTRVVERIADECR
>NC_017585.1|WP_014151270.1|912775_913390_-|TetR/AcrR-family-transcriptional-regulator
MAQQERALKTRLLIVEAAGAVFDELGYDAATTTEIIARSGVTRGALYFHFPSKEAIADAVIASQDQFLVPPDHRVRLQATIDLTMSYARRLQHDSLLRGAVRLAVEQASYRKPDATPYVSSHEVVCRLLREAEANGELLPTADPEELTPLIVGAFTGIQVLSQAHNNRLDLLERVSALWKNLLPAIAVAGLLPHLDTSPEARPR
>NC_017585.1|WP_014151271.1|911857_912766_+|helix-turn-helix-transcriptional-regulator
MIPRSFPALGDRGGGARHRPADRRPDRAAPPGGPSAGHPLPAFLRARRLRSGLSQEGLAWRLDVSTRTVSNWERGQHGVDPRRVADLAAALALTREEERELAGLAGSRTPAARPAPAPETPHPGDPAGFAREWHRGFRDVGMPAYLRDPAWRLLACNAAYTRLFSGVARVPEAIPRENLARFICLHPDAPRLLADWYEGWLVPLLCEISDDLRAAPPRSPLYALLKAVLARPEIARAWRTEVPARAAARIRSAAAPEPAAPRHIVHPDPAVGRAAVHVSSMVPQGLDGHRSVFWRLQSLEAP
>NC_017585.1|WP_014151272.1|910684_911575_-|helix-turn-helix-transcriptional-regulator
MTDAQPSGPVVEHGRGDLTAEERRQKLSFLREKRDSVDRSSFEARYPVEVPRRLPGRGRHAPGLTLVEMGRLLGLRDGSWYADLERGQVDNAPVDRLFKVAELLDLTPRQYEFLCVYACRPKPGYPAAGLPGGYREVLDLYQGPAYFQDAGWNLLRPKMYNAAAEALFNGIPDDFNFIRWVLLERSVRRPPEGGRRHAWLPDFWQVWAPRALPVVRAAYVARPDNATLARLHADLAADPEIGPIYQGRLPPYPHTDGDLRPFVHGSTGERGMVRINVLTPRGSDDTLMLLNWHPGA
>NC_017585.1|WP_014151273.1|909889_910669_+|SDR-family-oxidoreductase
MDLRMSGKTAVVTGASRGIGLAVVRTLTGEGVRVVGAARTVTAELKDAGAVPVAVDLSTPEGCAELVQRALAELGGIDLLVNNAGGGDHFTAAGFLTADDEIWERSWALNFFAPVRLIRAALPSLIERRGAIVNVSSIGARNATGPIDYATAKAALNTLGKALAAEFGPRGVRVNTVSPGPTRTPVWEDPDGYGAQQAALGGQELADYVARVPARSGQLTGRLVEPGEVADLIAFLGSDLAASVHGADYVIDGGALKTV
>NC_017585.1|WP_014151274.1|908676_909759_+|TetR/AcrR-family-transcriptional-regulator
MARLTRAETQERNRDKVLDAAREEFAERGYRDARIDAIAERAGLTRGAVYSNFPGKRALYFAVLAALAERVPEGPPPRPVRSGGDALAAFARAWVSRLPPAGDDGPGPARLAMDLMPEVITDAATRRPFAQLLKLDAILLGLALERLEPAGRPARRMVRVAEAVLTALHGTAQLAAAAPGFLDPLDAVRVCERLAGLPLDDDPPPAPGLPPVHHVDEPWSPPPATDAVTGDPLPADGEPDQVVTVLGLHRLEAAEDAVRAAPPDTPVTAVLVTADPGELGALARLSVAELCGCLRQAFPASARPPLRVVHDPSGAFAAAAGVPAVDDRTETAIRLASARVTARAQGPGAARAVAATPRRG
>NC_017585.1|WP_014151275.1|907853_908483_-|LysE-family-translocator
MLTTALAFLGACVLIAAAPGPSTMLIIRQSLHSRRAGFLTVLGNETGVLTWGVVAALGLTALLAASRTAYDVMRIGGAVVLVWYGVQTLRAARRGEARPSAADDEAAVVPRSGWKIYRSGLLLNLANPKAAVFAMSFLPQFVPAGAPKLPVITALAAFQALFEVGYYGMYVWFVGRMKRVISRAGVRRRLEQVSGGVLVLLGIRMAVES
>NC_017585.1|WP_014151276.1|906572_907664_-|zinc-binding-alcohol-dehydrogenase-family-protein
MTLPTETWAVRIHRHGGPEVLVHERLPLPPLGPADVLVAVDTASVSGWDVKYRRGLPPGARLPGRERYRLPLQLGREAAGTVLATGPEAAGRFRPGDRVVAVVHPENPRAPETVRGLGNLSTGIALPGHQAPGGYARYLICHQDMWLPLPSGVDLEQAAVTLWPYATCHRVLRDRLRVALGETLLVCGATGAMGLAALRLARLTGVRVIAMTRYRAKERALRTAGADEVVVAGDPRQACEAVRALTGGEGVDHAVDFTGSAALLRLAVDSLRLGGRLCPAATQRPPGPLPVTTGDLTRLEITVYGIRGARHRDALRVLALLGDGSLPATPIAARFPLSRAGAAHEFLEHNTTAVGRVVLKPGW
>NC_017585.1|WP_014151277.1|905436_906255_-|enoyl-CoA-hydratase/isomerase-family-protein
MKQESRQDRFEDQDEDRFAAQESIECSRLGDGIALAEFSGAHEQNPFSRARMRELTALMRELDADEKVRCVVLYGGAGRSFGVGGDFHEVSEFTGGDEVNAWIDDITDLYTTVAAISKPVIAAIDGYAIGVGLQISLCCDYRLGSEQARLVMPEFRVGIACNFGGFMLEAAAGRTVMQRMLLTCDEWPAERALADGLLHETVASPRLLDRALELARTISGYTAEAVQSTRPRVNAPFVAGLERIRREAKESHRRAFAAGEAQVRMRRVIGRS
>NC_017585.1|WP_014151278.1|904469_905453_+|GNAT-family-N-acetyltransferase
MSPRRLVPIRPADHLPALVRLAADRDRAALGRVEVGATWIAGRLAAPGLDPEHDTALLTGSDGQVAGAVWLSRSSGRSAWDAELLLAPHATPDDAASLLDFAHRRCRTIAAGRPEGEVCLSCFVSERETALRIALSAYGFAAPRPYLRMSVPLGGATAGEPPVPGAVVRVPEGEAGLRAFHAVKNRAFSAEEAGMEPDGFEEWLRWTGADPGADPSQRALLELDGEPVGFANVTDRMAQTRGAAYLRQIGVLPRMRGRRLGAFLLRSVMAAARARGRGEMVLTVDTGNRAGLALYRATGWREESRFYDYAYRVTATPAPAGEVSSAR
>NC_017585.1|WP_014151268.1|914196_914637_+|hypothetical-protein
MTDHTYLSDLPLAGDLVATGYEGWSPELRAEFEAHAHDGHVGSRLLSENARVRVWEIRLAPGDRWHAHRHVLDYFWTAITPGRSRQHTHDGTTRDVSYHAGETRHFTFGPGEFLLHDIENTGETELIFTTVEHLDSANAPLRLELR
>NC_017585.1|WP_106433081.1|915555_916071_-|ATP-binding-protein
MEPFLAIAPPDRCFDLTIERHSSNAELDQHDRRRPGVIRRICRAKLRHWGTCDDLTNDVLLASTELVTNALKHSYGARIRVSLSCWPGAVRIDVDDGAPSPPACPRSAGLLDEDGRGLAIVAALADAWGRSGSTTWCLLTADASEQPHGNLPLPPSGHLANPTTIRPASQE
>NC_017585.1|WP_014151264.1|917587_918127_+|hypothetical-protein
MKTAGIEIRHFPDVEPVWDTLIGIYAEVRADRLHDPHYSVERFGERLARHASEPGWEAAVGYDGDEPIGYAYANTIEQGDRWWKRVQCPVPDAVLCAPTLALKEIMVRVGWRKTGASRRIHDDLLAQRTEPQVSLMVNPQAGDGKVHALYETWGYTDVGPSRPSLDSPVLMVMVRERAM
>NC_017585.1|WP_014151263.1|918213_918858_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MAHTTDHVKALIAAERRELAAVLHALRPEQWEAPSLCTGWRVREVAAHMSTGFRHPTRKVLWELVKSAGRVNAMADRLARADATALTPGELADAMADNAHHPWKPPVGGYENALGHDVVHGLDITTALGLDRRIPEERLRVLLAGVTRTSARFFGAPLHGIRLQADDLDWTFGTGTPVTGNAQDLLLAAFGRKLPPGRLSGPGGGRFVRVPGVG
>NC_017585.1|WP_014151262.1|918940_920203_-|SGNH/GDSL-hydrolase-family-protein
MPAKSVGAAAALVLTAALAVAGARAAQSPPAPVWNAAWSAAPQRPSTGFTPNWSEAGFSGQTLRQVVRVTTGGSRLRIRLSNAYGTSPLHIAGATVARRDHGARLRAGTVRQLTFGGSRAATVPAYGQLTSDPAGLPLRAFEPVTVTLHLDGTTGPATFHAQSMATSYAADGDHTADVADTAFRRTTQSWYYLSGVDVSGGDRPVRPGRTGGIVLFGDSITDGFKSTPDRDHRWSDALAERLATTGRPRPVLNAGIGGNLVLNDSAWYGQRSSARFTRDALDLPGVRTVVILEGVDDIGYSETDKPTYKPAPVVTAAQLIDGHRELIRQARARGIRVVGATLLPFGGSDHYGTRAAAVSLAFDQWVRTSGEYDAYVDFAKALADPHHPERLDPRYDSGDHLHPNDAGYRAMARAMDLSAL
>NC_017585.1|WP_041823648.1|920448_921717_+|cytochrome-P450
MMKIRTRIGAWLGRRYMANLRKKGFDLSKALPESTLMPLRRDGLDPVPDLGAMRRKAPVTKLKVPLGVNVWLVTGYEEAKAVLGDAGSFSNDFTNLIGTGVTSGTSPGGLGFADPPDHTRLRRLLTPEFTMRRLSRLTPRIHTIVEERLAEMAAATGPVDLVEAFAMPIPSLVICELLGVPYEDREEFQRLGTSRFDVFSGADASFGAISESLSYLRDIVKKERENPGDGLLGMLVREHGDAIDDEELAGLADGVLTGGLETTASMLALGTLLMLQDRQHFTALLADDAAIDPFVDELLRYLTVVQVAFPRFARRDLEIGGQAIGSGDIVLCSLSGADRDEHLGPHMEEFDPTRPAAGSHLAFGHGIHRCIGAELAKMELRAAYPALVRRFPEMTLAVPAEELRFRKYSVVFGMESLPVNLG
>NC_017585.1|WP_014151260.1|921777_922716_-|alpha/beta-fold-hydrolase
MSRSDTNVPPSVPWSSARDYAELNVPVRGGELTVLRRAAREPGAPVVLALHGITANALAWSRVADHLAGRVTVVAPDLRGRAGSRALPGPYGIGAHAEDVAAVAEALGLESAVLAGHSMGAFVAALTAVRHPGRFASVVLVDGGLAFPAPAGLGTDELLEAVIGPAMRRLRMTFPDRDAYRDYWRVHPAFGGRWSPWTDAYLQRDLTGAEPELTSSCVLDAVREDGAGVFGDPRVRSAIRELPHPARLLWAERGLLDEPQGLYDEERLATAALEPDRVATHRIPDTNHYTVLGGDAGARAVAGHLLDAAGLR
>NC_017585.1|WP_014151259.1|922935_923184_+|hypothetical-protein
MSDRRSPSARTGSPSAPKRRRAGVTIAAVVVLGTVVGTGLPGRVDAGLSAPAHAAAPRDAVRRGVTALVPAVLAAVRGGHSS
>NC_017585.1|WP_014151258.1|923191_923599_-|hypothetical-protein
MSRRDRGEARAAGPARCTVTVCRGCCCGTGKVPGVDHAAQLAELRRALSGTATVRPVTCLDACEHANVIVVQPSAAGRAAGGRPVWLGLVNDPDAVGDITAWVEAGGPGLADPAGILDLYAFSPSRRIRRDAELS
>NC_017585.1|WP_014151257.1|923595_925572_-|heavy-metal-translocating-P-type-ATPase
MSSTLTRPAPRAGGDPAAPPPARRTRILALPEARWAALALAFFLIALAAQALGAPAWACGTLYALVYAAGGWEPGWAGLTALRQKTLDVDLLMVVAALGAAAIGQVLDGALLIVIFATSGALEALATARTADSVRGLLDLAPATATRITDDGAEETVPSAELAVGDVVLVRPGERIGADGRVLDGASEVDQATITGEPLPVAKSAGDEVFAGTLNGTGALRVKVERDPADSVIARIVAMVEEASGTLAPTQLFIEKVEQRYSIGMVAATLALFAVPLCFGAALQPTLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVMERLGQVDQVALDKTGTLTEGTPQVTDVRPVPGAGLTEDELLTVAAAAEHPSEHPLARAVVAAAAARGLRPPPVTDFASAPGTGVTATVDGRRVAVGSPTRLPAAADGPATVVAEELAGKGRTVVVVEVDGVPSGVLGIADRLRDQAPEAVAALTALTGHPPVLVTGDHAGAAVPLGRRTGITDIRAGLLPEQKVAVVRELERAGRRVLVVGDGVNDAPALAAAHTGVAMGRAGSDLALQTADAVVVRDELATVPAVVALSRRARSLVTQNLVVAAVFITGLVVWDLVGTLPLPLGVAGHEGSTVIVGLNGLRLLADSAWRRAATGRAS

Crispr_ID: NC_017585_2

• CRISPR_ID: NC_017585_2
• CRISPR_location: 914841-915112
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers
• Cas_protein_info: csa3

Consensus repeat of NC_017585_2

Consensus_repeat	Method
GGAACACCCCCGCGCTCGCGGGN	CRT
GTATCGTCCCCGCGAGCGCGGGGGTGTTCCT	PILER-CR

spacers of NC_017585_2

>2.1|914863|38|NC_017585|CRT
ACGACAGCGCGGCGACGCCGATCGCCCCGGCCGTCCAC
>2.2|914923|38|NC_017585|CRT
ACGACGCCTGCCGGTAGTCGTCCGTAGCCCCGTGTACC
>2.3|914983|39|NC_017585|CRT
GACGATAGGCGGAGGACCACCTGCGCTCCGCCGCGGAGA
>2.4|915044|39|NC_017585|CRT
GACGATGCCAAAACCCGCAGTCTGCGGACCTGGCGCAAA
>2.5|914992|30|NC_017585|PILER-CR
GCGGAGGACCACCTGCGCTCCGCCGCGGAG
>2.6|915053|30|NC_017585|PILER-CR
CAAAACCCGCAGTCTGCGGACCTGGCGCAA

CRISPR arrays and Neighbor proteins around NC_017585_2

CRISPR arrays

The CRISPR arrays of NC_017585_2

>merge|NC_017585|2|914841-915112|CRT,PILER-CR
GGAACACCCCCGCGCTCGCGGGACGACAGCGCGGCGACGCCGATCGCCCCGGCCGTCCACGGAACACCCCGCGCTCGCAGGGACGACGCCTGCCGGTAGTCGTCCGTAGCCCCGTGTACCGGAACACCCCCGCGCTCGCGGGGACGATAGGCGGAGGACCACCTGCGCTCCGCCGCGGAGAGGAACACCCCCGCGCTCGCGGGGACGATGCCAAAACCCGCAGTCTGCGGACCTGGCGCAAAGGAACACCCCCGCGCTCGCGGGGACGATAC

>NC_017585|2|1|914841-915104|CRT
GGAACACCCCCGCGCTCGCGGG	ACGACAGCGCGGCGACGCCGATCGCCCCGGCCGTCCAC
GGAACACCCCGCGCTCGCAGGG	ACGACGCCTGCCGGTAGTCGTCCGTAGCCCCGTGTACC
GGAACACCCCCGCGCTCGCGGG	GACGATAGGCGGAGGACCACCTGCGCTCCGCCGCGGAGA
GGAACACCCCCGCGCTCGCGGG	GACGATGCCAAAACCCGCAGTCTGCGGACCTGGCGCAAA
GGAACACCCCCGCGCTCGCGGG

>NC_017585|2|1|914961-915112|PILER-CR
GGAACACCCCCGCGCTCGCGGGGACGATAGG	CGGAGGACCACCTGCGCTCCGCCGCGGAGA
GGAACACCCCCGCGCTCGCGGGGACGATGCC	AAAACCCGCAGTCTGCGGACCTGGCGCAAA
GGAACACCCCCGCGCTCGCGGGGACGATAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017585.1|WP_014151276.1|906572_907664_-|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|223677
NC_017585.1|WP_014151258.1|923191_923599_-|hypothetical-protein	unknown	unknown	unknown
NC_017585.1|WP_014151263.1|918213_918858_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl|CDD|274422
NC_017585.1|WP_014151273.1|909889_910669_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|180604
NC_017585.1|WP_014151264.1|917587_918127_+|hypothetical-protein	unknown	unknown	unknown
NC_017585.1|WP_014151260.1|921777_922716_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|366166
NC_017585.1|WP_014151271.1|911857_912766_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197775
NC_017585.1|WP_041823648.1|920448_921717_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_017585.1|WP_014151270.1|912775_913390_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_017585.1|WP_106433081.1|915555_916071_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_017585.1|WP_014151269.1|913611_913911_-|hypothetical-protein	unknown	unknown	unknown
NC_017585.1|WP_014151259.1|922935_923184_+|hypothetical-protein	unknown	unknown	unknown
NC_017585.1|WP_014151262.1|918940_920203_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
NC_017585.1|WP_014151277.1|905436_906255_-|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|119339
NC_017585.1|WP_014151257.1|923595_925572_-|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319849
NC_017585.1|WP_014151274.1|908676_909759_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_017585.1|WP_014151256.1|925680_926064_+|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
NC_017585.1|WP_014151272.1|910684_911575_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|375319
NC_017585.1|WP_014151268.1|914196_914637_+|hypothetical-protein	unknown	unknown	gnl|CDD|380387
NC_017585.1|WP_014151275.1|907853_908483_-|LysE-family-translocator	unknown	unknown	gnl|CDD|224199

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_017585.1|WP_014151256.1|925680_926064_+|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	6.7e-18	59.9	0.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017585.1|WP_014151276.1|906572_907664_-|zinc-binding-alcohol-dehydrogenase-family-protein	gnl|CDD|223677	COG0604, Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only].	8.27513e-57
NC_017585.1|WP_014151263.1|918213_918858_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl|CDD|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	3.50229e-17
NC_017585.1|WP_014151273.1|909889_910669_+|SDR-family-oxidoreductase	gnl|CDD|180604	PRK06523, PRK06523, short chain dehydrogenase; Provisional.	1.13177e-72
NC_017585.1|WP_014151256.1|925680_926064_+|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	6.64344e-18
NC_017585.1|WP_014151260.1|921777_922716_-|alpha/beta-fold-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	7.55385e-19
NC_017585.1|WP_014151271.1|911857_912766_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	2.42221e-09
NC_017585.1|WP_041823648.1|920448_921717_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.59634e-75
NC_017585.1|WP_106433081.1|915555_916071_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	3.86086e-16
NC_017585.1|WP_014151270.1|912775_913390_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.7826e-13
NC_017585.1|WP_014151257.1|923595_925572_-|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319849	cd07551, P-type_ATPase_HM_ZosA_PfeT-like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron. Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_017585.1|WP_014151262.1|918940_920203_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	8.52117e-87
NC_017585.1|WP_014151277.1|905436_906255_-|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	8.5613e-47
NC_017585.1|WP_014151274.1|908676_909759_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.82506e-12
NC_017585.1|WP_014151272.1|910684_911575_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.8629e-07
NC_017585.1|WP_014151268.1|914196_914637_+|hypothetical-protein	gnl|CDD|380387	cd06982, cupin_BauB-like, Pseudomonas aeruginosa BauB and related proteins, cupin domain. This family includes bacterial proteins homologous to beta-alanine degradation protein BauB from Pseudomonas aeruginosa, which is involved in the degradation of beta-alanine. Also included are Rhodopseudomonas palustris Rpa4178 and Bordetella pertussis Bp2299, which are both proteins with unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.64261e-08
NC_017585.1|WP_014151275.1|907853_908483_-|LysE-family-translocator	gnl|CDD|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.93381e-36

Protein sequences

>NC_017585.1|WP_014151268.1|914196_914637_+|hypothetical-protein
MTDHTYLSDLPLAGDLVATGYEGWSPELRAEFEAHAHDGHVGSRLLSENARVRVWEIRLAPGDRWHAHRHVLDYFWTAITPGRSRQHTHDGTTRDVSYHAGETRHFTFGPGEFLLHDIENTGETELIFTTVEHLDSANAPLRLELR
>NC_017585.1|WP_014151269.1|913611_913911_-|hypothetical-protein
MHLLARLLAGTALAACVTVVVVPAWTAPGAPAASGARCGGLSGPRRGVGYDNCAAHAVRIRVGHYVGVGDDYVCVPAFGRYRAPGWNTRVVERIADECR
>NC_017585.1|WP_014151270.1|912775_913390_-|TetR/AcrR-family-transcriptional-regulator
MAQQERALKTRLLIVEAAGAVFDELGYDAATTTEIIARSGVTRGALYFHFPSKEAIADAVIASQDQFLVPPDHRVRLQATIDLTMSYARRLQHDSLLRGAVRLAVEQASYRKPDATPYVSSHEVVCRLLREAEANGELLPTADPEELTPLIVGAFTGIQVLSQAHNNRLDLLERVSALWKNLLPAIAVAGLLPHLDTSPEARPR
>NC_017585.1|WP_014151271.1|911857_912766_+|helix-turn-helix-transcriptional-regulator
MIPRSFPALGDRGGGARHRPADRRPDRAAPPGGPSAGHPLPAFLRARRLRSGLSQEGLAWRLDVSTRTVSNWERGQHGVDPRRVADLAAALALTREEERELAGLAGSRTPAARPAPAPETPHPGDPAGFAREWHRGFRDVGMPAYLRDPAWRLLACNAAYTRLFSGVARVPEAIPRENLARFICLHPDAPRLLADWYEGWLVPLLCEISDDLRAAPPRSPLYALLKAVLARPEIARAWRTEVPARAAARIRSAAAPEPAAPRHIVHPDPAVGRAAVHVSSMVPQGLDGHRSVFWRLQSLEAP
>NC_017585.1|WP_014151272.1|910684_911575_-|helix-turn-helix-transcriptional-regulator
MTDAQPSGPVVEHGRGDLTAEERRQKLSFLREKRDSVDRSSFEARYPVEVPRRLPGRGRHAPGLTLVEMGRLLGLRDGSWYADLERGQVDNAPVDRLFKVAELLDLTPRQYEFLCVYACRPKPGYPAAGLPGGYREVLDLYQGPAYFQDAGWNLLRPKMYNAAAEALFNGIPDDFNFIRWVLLERSVRRPPEGGRRHAWLPDFWQVWAPRALPVVRAAYVARPDNATLARLHADLAADPEIGPIYQGRLPPYPHTDGDLRPFVHGSTGERGMVRINVLTPRGSDDTLMLLNWHPGA
>NC_017585.1|WP_014151273.1|909889_910669_+|SDR-family-oxidoreductase
MDLRMSGKTAVVTGASRGIGLAVVRTLTGEGVRVVGAARTVTAELKDAGAVPVAVDLSTPEGCAELVQRALAELGGIDLLVNNAGGGDHFTAAGFLTADDEIWERSWALNFFAPVRLIRAALPSLIERRGAIVNVSSIGARNATGPIDYATAKAALNTLGKALAAEFGPRGVRVNTVSPGPTRTPVWEDPDGYGAQQAALGGQELADYVARVPARSGQLTGRLVEPGEVADLIAFLGSDLAASVHGADYVIDGGALKTV
>NC_017585.1|WP_014151274.1|908676_909759_+|TetR/AcrR-family-transcriptional-regulator
MARLTRAETQERNRDKVLDAAREEFAERGYRDARIDAIAERAGLTRGAVYSNFPGKRALYFAVLAALAERVPEGPPPRPVRSGGDALAAFARAWVSRLPPAGDDGPGPARLAMDLMPEVITDAATRRPFAQLLKLDAILLGLALERLEPAGRPARRMVRVAEAVLTALHGTAQLAAAAPGFLDPLDAVRVCERLAGLPLDDDPPPAPGLPPVHHVDEPWSPPPATDAVTGDPLPADGEPDQVVTVLGLHRLEAAEDAVRAAPPDTPVTAVLVTADPGELGALARLSVAELCGCLRQAFPASARPPLRVVHDPSGAFAAAAGVPAVDDRTETAIRLASARVTARAQGPGAARAVAATPRRG
>NC_017585.1|WP_014151275.1|907853_908483_-|LysE-family-translocator
MLTTALAFLGACVLIAAAPGPSTMLIIRQSLHSRRAGFLTVLGNETGVLTWGVVAALGLTALLAASRTAYDVMRIGGAVVLVWYGVQTLRAARRGEARPSAADDEAAVVPRSGWKIYRSGLLLNLANPKAAVFAMSFLPQFVPAGAPKLPVITALAAFQALFEVGYYGMYVWFVGRMKRVISRAGVRRRLEQVSGGVLVLLGIRMAVES
>NC_017585.1|WP_014151276.1|906572_907664_-|zinc-binding-alcohol-dehydrogenase-family-protein
MTLPTETWAVRIHRHGGPEVLVHERLPLPPLGPADVLVAVDTASVSGWDVKYRRGLPPGARLPGRERYRLPLQLGREAAGTVLATGPEAAGRFRPGDRVVAVVHPENPRAPETVRGLGNLSTGIALPGHQAPGGYARYLICHQDMWLPLPSGVDLEQAAVTLWPYATCHRVLRDRLRVALGETLLVCGATGAMGLAALRLARLTGVRVIAMTRYRAKERALRTAGADEVVVAGDPRQACEAVRALTGGEGVDHAVDFTGSAALLRLAVDSLRLGGRLCPAATQRPPGPLPVTTGDLTRLEITVYGIRGARHRDALRVLALLGDGSLPATPIAARFPLSRAGAAHEFLEHNTTAVGRVVLKPGW
>NC_017585.1|WP_014151277.1|905436_906255_-|enoyl-CoA-hydratase/isomerase-family-protein
MKQESRQDRFEDQDEDRFAAQESIECSRLGDGIALAEFSGAHEQNPFSRARMRELTALMRELDADEKVRCVVLYGGAGRSFGVGGDFHEVSEFTGGDEVNAWIDDITDLYTTVAAISKPVIAAIDGYAIGVGLQISLCCDYRLGSEQARLVMPEFRVGIACNFGGFMLEAAAGRTVMQRMLLTCDEWPAERALADGLLHETVASPRLLDRALELARTISGYTAEAVQSTRPRVNAPFVAGLERIRREAKESHRRAFAAGEAQVRMRRVIGRS
>NC_017585.1|WP_106433081.1|915555_916071_-|ATP-binding-protein
MEPFLAIAPPDRCFDLTIERHSSNAELDQHDRRRPGVIRRICRAKLRHWGTCDDLTNDVLLASTELVTNALKHSYGARIRVSLSCWPGAVRIDVDDGAPSPPACPRSAGLLDEDGRGLAIVAALADAWGRSGSTTWCLLTADASEQPHGNLPLPPSGHLANPTTIRPASQE
>NC_017585.1|WP_014151264.1|917587_918127_+|hypothetical-protein
MKTAGIEIRHFPDVEPVWDTLIGIYAEVRADRLHDPHYSVERFGERLARHASEPGWEAAVGYDGDEPIGYAYANTIEQGDRWWKRVQCPVPDAVLCAPTLALKEIMVRVGWRKTGASRRIHDDLLAQRTEPQVSLMVNPQAGDGKVHALYETWGYTDVGPSRPSLDSPVLMVMVRERAM
>NC_017585.1|WP_014151263.1|918213_918858_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MAHTTDHVKALIAAERRELAAVLHALRPEQWEAPSLCTGWRVREVAAHMSTGFRHPTRKVLWELVKSAGRVNAMADRLARADATALTPGELADAMADNAHHPWKPPVGGYENALGHDVVHGLDITTALGLDRRIPEERLRVLLAGVTRTSARFFGAPLHGIRLQADDLDWTFGTGTPVTGNAQDLLLAAFGRKLPPGRLSGPGGGRFVRVPGVG
>NC_017585.1|WP_014151262.1|918940_920203_-|SGNH/GDSL-hydrolase-family-protein
MPAKSVGAAAALVLTAALAVAGARAAQSPPAPVWNAAWSAAPQRPSTGFTPNWSEAGFSGQTLRQVVRVTTGGSRLRIRLSNAYGTSPLHIAGATVARRDHGARLRAGTVRQLTFGGSRAATVPAYGQLTSDPAGLPLRAFEPVTVTLHLDGTTGPATFHAQSMATSYAADGDHTADVADTAFRRTTQSWYYLSGVDVSGGDRPVRPGRTGGIVLFGDSITDGFKSTPDRDHRWSDALAERLATTGRPRPVLNAGIGGNLVLNDSAWYGQRSSARFTRDALDLPGVRTVVILEGVDDIGYSETDKPTYKPAPVVTAAQLIDGHRELIRQARARGIRVVGATLLPFGGSDHYGTRAAAVSLAFDQWVRTSGEYDAYVDFAKALADPHHPERLDPRYDSGDHLHPNDAGYRAMARAMDLSAL
>NC_017585.1|WP_041823648.1|920448_921717_+|cytochrome-P450
MMKIRTRIGAWLGRRYMANLRKKGFDLSKALPESTLMPLRRDGLDPVPDLGAMRRKAPVTKLKVPLGVNVWLVTGYEEAKAVLGDAGSFSNDFTNLIGTGVTSGTSPGGLGFADPPDHTRLRRLLTPEFTMRRLSRLTPRIHTIVEERLAEMAAATGPVDLVEAFAMPIPSLVICELLGVPYEDREEFQRLGTSRFDVFSGADASFGAISESLSYLRDIVKKERENPGDGLLGMLVREHGDAIDDEELAGLADGVLTGGLETTASMLALGTLLMLQDRQHFTALLADDAAIDPFVDELLRYLTVVQVAFPRFARRDLEIGGQAIGSGDIVLCSLSGADRDEHLGPHMEEFDPTRPAAGSHLAFGHGIHRCIGAELAKMELRAAYPALVRRFPEMTLAVPAEELRFRKYSVVFGMESLPVNLG
>NC_017585.1|WP_014151260.1|921777_922716_-|alpha/beta-fold-hydrolase
MSRSDTNVPPSVPWSSARDYAELNVPVRGGELTVLRRAAREPGAPVVLALHGITANALAWSRVADHLAGRVTVVAPDLRGRAGSRALPGPYGIGAHAEDVAAVAEALGLESAVLAGHSMGAFVAALTAVRHPGRFASVVLVDGGLAFPAPAGLGTDELLEAVIGPAMRRLRMTFPDRDAYRDYWRVHPAFGGRWSPWTDAYLQRDLTGAEPELTSSCVLDAVREDGAGVFGDPRVRSAIRELPHPARLLWAERGLLDEPQGLYDEERLATAALEPDRVATHRIPDTNHYTVLGGDAGARAVAGHLLDAAGLR
>NC_017585.1|WP_014151259.1|922935_923184_+|hypothetical-protein
MSDRRSPSARTGSPSAPKRRRAGVTIAAVVVLGTVVGTGLPGRVDAGLSAPAHAAAPRDAVRRGVTALVPAVLAAVRGGHSS
>NC_017585.1|WP_014151258.1|923191_923599_-|hypothetical-protein
MSRRDRGEARAAGPARCTVTVCRGCCCGTGKVPGVDHAAQLAELRRALSGTATVRPVTCLDACEHANVIVVQPSAAGRAAGGRPVWLGLVNDPDAVGDITAWVEAGGPGLADPAGILDLYAFSPSRRIRRDAELS
>NC_017585.1|WP_014151257.1|923595_925572_-|heavy-metal-translocating-P-type-ATPase
MSSTLTRPAPRAGGDPAAPPPARRTRILALPEARWAALALAFFLIALAAQALGAPAWACGTLYALVYAAGGWEPGWAGLTALRQKTLDVDLLMVVAALGAAAIGQVLDGALLIVIFATSGALEALATARTADSVRGLLDLAPATATRITDDGAEETVPSAELAVGDVVLVRPGERIGADGRVLDGASEVDQATITGEPLPVAKSAGDEVFAGTLNGTGALRVKVERDPADSVIARIVAMVEEASGTLAPTQLFIEKVEQRYSIGMVAATLALFAVPLCFGAALQPTLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVMERLGQVDQVALDKTGTLTEGTPQVTDVRPVPGAGLTEDELLTVAAAAEHPSEHPLARAVVAAAAARGLRPPPVTDFASAPGTGVTATVDGRRVAVGSPTRLPAAADGPATVVAEELAGKGRTVVVVEVDGVPSGVLGIADRLRDQAPEAVAALTALTGHPPVLVTGDHAGAAVPLGRRTGITDIRAGLLPEQKVAVVRELERAGRRVLVVGDGVNDAPALAAAHTGVAMGRAGSDLALQTADAVVVRDELATVPAVVALSRRARSLVTQNLVVAAVFITGLVVWDLVGTLPLPLGVAGHEGSTVIVGLNGLRLLADSAWRRAATGRAS
>NC_017585.1|WP_014151256.1|925680_926064_+|winged-helix-turn-helix-transcriptional-regulator
MGHGAAATASNAVPRARLDAADAAKVATTLQALATPSRLLILARLREGPLPATELAAEVGMEQSACSHQLRLLRNLGLVTGTRQGRSVVYALYDNHVAELLDQALYHVEHLRLGLTDGPVDEDAAAG

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_017585_1	1.1|914084|60|NC_017585|CRISPRCasFinder	914084-914143	60	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	914084-914143	0	1.0
NC_017585_1	1.1|914084|60|NC_017585|CRISPRCasFinder	914084-914143	60	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	899011-899070	0	1.0
NC_017585_2	2.1|914863|38|NC_017585|CRT	914863-914900	38	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	914863-914900	0	1.0
NC_017585_2	2.1|914863|38|NC_017585|CRT	914863-914900	38	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	898254-898291	0	1.0
NC_017585_2	2.2|914923|38|NC_017585|CRT	914923-914960	38	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	898194-898231	0	1.0
NC_017585_2	2.2|914923|38|NC_017585|CRT	914923-914960	38	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	914923-914960	0	1.0
NC_017585_2	2.3|914983|39|NC_017585|CRT	914983-915021	39	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	898133-898171	0	1.0
NC_017585_2	2.3|914983|39|NC_017585|CRT	914983-915021	39	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	914983-915021	0	1.0
NC_017585_2	2.4|915044|39|NC_017585|CRT	915044-915082	39	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	898072-898110	0	1.0
NC_017585_2	2.4|915044|39|NC_017585|CRT	915044-915082	39	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	915044-915082	0	1.0
NC_017585_2	2.5|914992|30|NC_017585|PILER-CR	914992-915021	30	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	914991-915020	0	1.0
NC_017585_2	2.5|914992|30|NC_017585|PILER-CR	914992-915021	30	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	898134-898163	0	1.0
NC_017585_2	2.6|915053|30|NC_017585|PILER-CR	915053-915082	30	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	915052-915081	0	1.0
NC_017585_2	2.6|915053|30|NC_017585|PILER-CR	915053-915082	30	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	898073-898102	0	1.0
NC_017585_2	2.5|914992|30|NC_017585|PILER-CR	914992-915021	30	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	1944803-1944832	5	0.833
NC_017585_2	2.5|914992|30|NC_017585|PILER-CR	914992-915021	30	NC_008043	Ruegeria sp. TM1040 megaplasmid, complete sequence	391142-391171	7	0.767
NC_017585_2	2.5|914992|30|NC_017585|PILER-CR	914992-915021	30	NZ_CP017782	Rhodobacter sp. LPB0142 plasmid pEJ01, complete sequence	227518-227547	7	0.767
NC_017585_2	2.5|914992|30|NC_017585|PILER-CR	914992-915021	30	NZ_CP013069	Pannonibacter phragmitetus strain 31801 plasmid p.p-1, complete sequence	123203-123232	7	0.767
NC_017585_2	2.5|914992|30|NC_017585|PILER-CR	914992-915021	30	NZ_CP032313	Pannonibacter phragmitetus BB plasmid p.BB_1, complete sequence	303201-303230	7	0.767
NC_017585_2	2.1|914863|38|NC_017585|CRT	914863-914900	38	NZ_CP017076	Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence	1147739-1147776	8	0.789
NC_017585_2	2.5|914992|30|NC_017585|PILER-CR	914992-915021	30	CP003950	Rhodococcus opacus PD630 plasmid 1, complete sequence	126789-126818	8	0.733
NC_017585_2	2.5|914992|30|NC_017585|PILER-CR	914992-915021	30	NZ_CP040820	Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence	27958-27987	8	0.733
NC_017585_2	2.5|914992|30|NC_017585|PILER-CR	914992-915021	30	NC_013857	Azospirillum sp. B510 plasmid pAB510c, complete sequence	421386-421415	10	0.667

1. spacer 1.1|914084|60|NC_017585|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

gacaccatcaccgttgcggatcgcctcgttccgtcgccggtcaactggcaccgttggccc	CRISPR spacer
gacaccatcaccgttgcggatcgcctcgttccgtcgccggtcaactggcaccgttggccc	Protospacer
************************************************************

2. spacer 1.1|914084|60|NC_017585|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

gacaccatcaccgttgcggatcgcctcgttccgtcgccggtcaactggcaccgttggccc	CRISPR spacer
gacaccatcaccgttgcggatcgcctcgttccgtcgccggtcaactggcaccgttggccc	Protospacer
************************************************************

3. spacer 2.1|914863|38|NC_017585|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

acgacagcgcggcgacgccgatcgccccggccgtccac	CRISPR spacer
acgacagcgcggcgacgccgatcgccccggccgtccac	Protospacer
**************************************

4. spacer 2.1|914863|38|NC_017585|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

acgacagcgcggcgacgccgatcgccccggccgtccac	CRISPR spacer
acgacagcgcggcgacgccgatcgccccggccgtccac	Protospacer
**************************************

5. spacer 2.2|914923|38|NC_017585|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

acgacgcctgccggtagtcgtccgtagccccgtgtacc	CRISPR spacer
acgacgcctgccggtagtcgtccgtagccccgtgtacc	Protospacer
**************************************

6. spacer 2.2|914923|38|NC_017585|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

acgacgcctgccggtagtcgtccgtagccccgtgtacc	CRISPR spacer
acgacgcctgccggtagtcgtccgtagccccgtgtacc	Protospacer
**************************************

7. spacer 2.3|914983|39|NC_017585|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

gacgataggcggaggaccacctgcgctccgccgcggaga	CRISPR spacer
gacgataggcggaggaccacctgcgctccgccgcggaga	Protospacer
***************************************

8. spacer 2.3|914983|39|NC_017585|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

gacgataggcggaggaccacctgcgctccgccgcggaga	CRISPR spacer
gacgataggcggaggaccacctgcgctccgccgcggaga	Protospacer
***************************************

9. spacer 2.4|915044|39|NC_017585|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

gacgatgccaaaacccgcagtctgcggacctggcgcaaa	CRISPR spacer
gacgatgccaaaacccgcagtctgcggacctggcgcaaa	Protospacer
***************************************

10. spacer 2.4|915044|39|NC_017585|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

gacgatgccaaaacccgcagtctgcggacctggcgcaaa	CRISPR spacer
gacgatgccaaaacccgcagtctgcggacctggcgcaaa	Protospacer
***************************************

11. spacer 2.5|914992|30|NC_017585|PILER-CR matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

gcggaggaccacctgcgctccgccgcggag	CRISPR spacer
gcggaggaccacctgcgctccgccgcggag	Protospacer
******************************

12. spacer 2.5|914992|30|NC_017585|PILER-CR matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

gcggaggaccacctgcgctccgccgcggag	CRISPR spacer
gcggaggaccacctgcgctccgccgcggag	Protospacer
******************************

13. spacer 2.6|915053|30|NC_017585|PILER-CR matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

caaaacccgcagtctgcggacctggcgcaa	CRISPR spacer
caaaacccgcagtctgcggacctggcgcaa	Protospacer
******************************

14. spacer 2.6|915053|30|NC_017585|PILER-CR matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

caaaacccgcagtctgcggacctggcgcaa	CRISPR spacer
caaaacccgcagtctgcggacctggcgcaa	Protospacer
******************************

15. spacer 2.5|914992|30|NC_017585|PILER-CR matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 5, identity: 0.833

gcggaggaccacctgcgctccgccgcggag	CRISPR spacer
gaagaagaccacctccgctccgccgcggcg	Protospacer
* .**.******** ************* *

16. spacer 2.5|914992|30|NC_017585|PILER-CR matches to NC_008043 (Ruegeria sp. TM1040 megaplasmid, complete sequence) position: , mismatch: 7, identity: 0.767

gcggaggaccacctgcgctccgccgcggag	CRISPR spacer
ggcgaggatcacctgcgccccgccgcgtcc	Protospacer
*  *****.*********.********   

17. spacer 2.5|914992|30|NC_017585|PILER-CR matches to NZ_CP017782 (Rhodobacter sp. LPB0142 plasmid pEJ01, complete sequence) position: , mismatch: 7, identity: 0.767

gcggaggaccacctgcgctccgccgcggag	CRISPR spacer
gtcgaggaccacatgcgctccgccatgccg	Protospacer
*. ********* ***********..*  *

18. spacer 2.5|914992|30|NC_017585|PILER-CR matches to NZ_CP013069 (Pannonibacter phragmitetus strain 31801 plasmid p.p-1, complete sequence) position: , mismatch: 7, identity: 0.767

gcggaggaccacctgcgctccgccgcggag	CRISPR spacer
acgccggaccagctgcgctccgccgcccgg	Protospacer
.**  ****** **************  .*

19. spacer 2.5|914992|30|NC_017585|PILER-CR matches to NZ_CP032313 (Pannonibacter phragmitetus BB plasmid p.BB_1, complete sequence) position: , mismatch: 7, identity: 0.767

gcggaggaccacctgcgctccgccgcggag	CRISPR spacer
acgccggaccagctgcgctccgccgcccgg	Protospacer
.**  ****** **************  .*

20. spacer 2.1|914863|38|NC_017585|CRT matches to NZ_CP017076 (Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence) position: , mismatch: 8, identity: 0.789

acgacagcgcggcgacgccgatcgccccggc---cgtccac	CRISPR spacer
aggccagcgcggcgacgccgagcgctccggcatgggtc---	Protospacer
* * ***************** ***.*****    ***   

21. spacer 2.5|914992|30|NC_017585|PILER-CR matches to CP003950 (Rhodococcus opacus PD630 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.733

gcggaggaccacctgcgctccgccgcggag	CRISPR spacer
ctgatcgaccacctccgctccgccgcgccg	Protospacer
 .*.  ******** ************  *

22. spacer 2.5|914992|30|NC_017585|PILER-CR matches to NZ_CP040820 (Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence) position: , mismatch: 8, identity: 0.733

gcggaggaccacctgcgctccgccgcggag	CRISPR spacer
atggaggaccacctgcgctttgccgtgtgc	Protospacer
..*****************..****.* . 

23. spacer 2.5|914992|30|NC_017585|PILER-CR matches to NC_013857 (Azospirillum sp. B510 plasmid pAB510c, complete sequence) position: , mismatch: 10, identity: 0.667

gcggaggaccacctgcgctccgccgcggag	CRISPR spacer
ttccaggaccaactgcgctccgccgaaagc	Protospacer
 .  ******* ************* ...