CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_017167	Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1, complete sequence	6 crisprs	c2c9_V-U4,csa3,cas3,DEDDh,DinG,cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7,csx1,csm6,csb2gr5,cas7,cas8u1,cas2,cas1,cas4,csb1gr7	0	12	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_017167_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017167_1

38229-39732

TypeV-U4

Consensus_repeat	Method
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	PILER-CR
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CRISPRCasFinder
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CRT

20 spacers

c2c9_V-U4

The CRISPR arrays of NC_017167_1

>merge|NC_017167|1|38229-39732|PILER-CR,CRISPRCasFinder,CRT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCGCGAGGACTCAAGGCGAAGGAGGTGGCGGAGGCCATGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCTCTGCGTTCTTGATAGGGTCATCGATAAGGAGAAGACGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCACAAATCCCATCAACAAAACCAGCAACGATTATATGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCCCAATGGTTCCTACTCAGTTAGCTGAACACTGGAAGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCACCCTCACCGACTGATTTCGAGATGTTCAATAATGGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCGGCGTAAAACCGGCCTCTTCCCATTCACGGGCGGCGCGGGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCTTATCACCCACGCTCACCCTGTCCGTGTCGCTCTCGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCTACACGCTATACGCTACGCCGGATCGCTTGCGGCTCGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCAAGACGCGGCGGCTCCACGGCATCCGCGACATTGCGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCTCGTATGAGGTGAGACAGCATGGCGAGCGTGCAACAAGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCACTAACCTAAACTGATTCGCTTGACGATTCCCGTTTGGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCATATCCACGCGCATACGACCGATCCGAATATGGTCGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCGGTAACAGGGACGGATGCGTGATGACAGAGCATGAGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCATTTTCGTCTCCGACCAGATACCACGTGAGCTGCGAAGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCATACCCGCTCTCGCCGTGTCATTCGGTGTTGGCGGTGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCTTCGCCATCGTCGTCGGTTACGGTCGGTGCGGGAGAGTGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCTCAATGGGCCGAGAGACGTGGACAAAGGTTAGGTGGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCAGCGCAAGGCCAGGACTTCGCCGACGCGCATGCCGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCGTCGATCAAGCCAAGTTACAAGGGATCGGTCGCTCAGTGTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCTGAACTATTTGGTGTCGTGGCTGAACCGCTTTGAAGTTGCTCCGCCGAGATCGTCGGCGGCCCCAATCACGA

>NC_017167|1|1|38229-39659|PILER-CR
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GCGAGGACTCAAGGCGAAGGAGGTGGCGGAGGCCAT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CTCTGCGTTCTTGATAGGGTCATCGATAAGGAGAAGAC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACAAATCCCATCAACAAAACCAGCAACGATTATAT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CCCAATGGTTCCTACTCAGTTAGCTGAACACTGGAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACCCTCACCGACTGATTTCGAGATGTTCAATAATG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GGCGTAAAACCGGCCTCTTCCCATTCACGGGCGGCGCGG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TTATCACCCACGCTCACCCTGTCCGTGTCGCTCTC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TACACGCTATACGCTACGCCGGATCGCTTGCGGCTC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	AAGACGCGGCGGCTCCACGGCATCCGCGACATTGC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TCGTATGAGGTGAGACAGCATGGCGAGCGTGCAACAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACTAACCTAAACTGATTCGCTTGACGATTCCCGTTTG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CATATCCACGCGCATACGACCGATCCGAATATGGTC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GGTAACAGGGACGGATGCGTGATGACAGAGCATGA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ATTTTCGTCTCCGACCAGATACCACGTGAGCTGCGAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CATACCCGCTCTCGCCGTGTCATTCGGTGTTGGCGGT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TTCGCCATCGTCGTCGGTTACGGTCGGTGCGGGAGAGT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CTCAATGGGCCGAGAGACGTGGACAAAGGTTAGGTG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CAGCGCAAGGCCAGGACTTCGCCGACGCGCATGCC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GTCGATCAAGCCAAGTTACAAGGGATCGGTCGCTCAGT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC

>NC_017167|1|1|38229-39732|CRISPRCasFinder
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GCGAGGACTCAAGGCGAAGGAGGTGGCGGAGGCCAT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CTCTGCGTTCTTGATAGGGTCATCGATAAGGAGAAGAC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACAAATCCCATCAACAAAACCAGCAACGATTATAT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CCCAATGGTTCCTACTCAGTTAGCTGAACACTGGAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACCCTCACCGACTGATTTCGAGATGTTCAATAATG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GGCGTAAAACCGGCCTCTTCCCATTCACGGGCGGCGCGG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TTATCACCCACGCTCACCCTGTCCGTGTCGCTCTC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TACACGCTATACGCTACGCCGGATCGCTTGCGGCTC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	AAGACGCGGCGGCTCCACGGCATCCGCGACATTGC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TCGTATGAGGTGAGACAGCATGGCGAGCGTGCAACAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACTAACCTAAACTGATTCGCTTGACGATTCCCGTTTG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CATATCCACGCGCATACGACCGATCCGAATATGGTC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GGTAACAGGGACGGATGCGTGATGACAGAGCATGA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ATTTTCGTCTCCGACCAGATACCACGTGAGCTGCGAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CATACCCGCTCTCGCCGTGTCATTCGGTGTTGGCGGT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TTCGCCATCGTCGTCGGTTACGGTCGGTGCGGGAGAGT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CTCAATGGGCCGAGAGACGTGGACAAAGGTTAGGTG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CAGCGCAAGGCCAGGACTTCGCCGACGCGCATGCC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GTCGATCAAGCCAAGTTACAAGGGATCGGTCGCTCAGT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CTGAACTATTTGGTGTCGTGGCTGAACCGCTTTGAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCAATCACGA

>NC_017167|1|1|38229-39732|CRT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GCGAGGACTCAAGGCGAAGGAGGTGGCGGAGGCCAT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CTCTGCGTTCTTGATAGGGTCATCGATAAGGAGAAGAC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACAAATCCCATCAACAAAACCAGCAACGATTATAT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CCCAATGGTTCCTACTCAGTTAGCTGAACACTGGAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACCCTCACCGACTGATTTCGAGATGTTCAATAATG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GGCGTAAAACCGGCCTCTTCCCATTCACGGGCGGCGCGG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TTATCACCCACGCTCACCCTGTCCGTGTCGCTCTC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TACACGCTATACGCTACGCCGGATCGCTTGCGGCTC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	AAGACGCGGCGGCTCCACGGCATCCGCGACATTGC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TCGTATGAGGTGAGACAGCATGGCGAGCGTGCAACAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACTAACCTAAACTGATTCGCTTGACGATTCCCGTTTG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CATATCCACGCGCATACGACCGATCCGAATATGGTC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GGTAACAGGGACGGATGCGTGATGACAGAGCATGA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ATTTTCGTCTCCGACCAGATACCACGTGAGCTGCGAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CATACCCGCTCTCGCCGTGTCATTCGGTGTTGGCGGT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TTCGCCATCGTCGTCGGTTACGGTCGGTGCGGGAGAGT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CTCAATGGGCCGAGAGACGTGGACAAAGGTTAGGTG
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CAGCGCAAGGCCAGGACTTCGCCGACGCGCATGCC
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GTCGATCAAGCCAAGTTACAAGGGATCGGTCGCTCAGT
GTTGCTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CTGAACTATTTGGTGTCGTGGCTGAACCGCTTTGAA
GTTGCTCCGCCGAGATCGTCGGCGGCCCCAATCACGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017167.1\|WP_041695572.1\|31394_32333_+\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NC_017167.1\|WP_014462923.1\|26505_28206_-\|IS1634-family-transposase	unknown	unknown	gnl\|CDD\|227708
NC_017167.1\|WP_041695577.1\|49613_50183_+\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|376404
NC_017167.1\|WP_041695573.1\|41002_41590_-\|IS607-family-transposase	unknown	unknown	gnl\|CDD\|225296
NC_017167.1\|WP_041694819.1\|41625_42846_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_017167.1\|WP_049784300.1\|23414_23795_+\|IS66-family-insertion-sequence-hypothetical-protein	unknown	unknown	gnl\|CDD\|379154
NC_017167.1\|WP_041695576.1\|48119_49439_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|273327
NC_017167.1\|WP_014462932.1\|36507_37791_+\|isocitrate-lyase	unknown	unknown	gnl\|CDD\|237893
NC_017167.1\|WP_014462925.1\|28517_29870_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NC_017167.1\|WP_041695575.1\|46661_47735_-\|BMP-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380577
NC_017167.1\|WP_014462941.1\|43995_45069_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226962
NC_017167.1\|WP_049784393.1\|24219_25806_+\|IS66-family-transposase	unknown	unknown	gnl\|CDD\|376980
NC_017167.1\|WP_014462938.1\|39879_41031_-\|transposase	c2c9_V-U4	-	gnl\|CDD\|223747
NC_017167.1\|WP_041694816.1\|30253_31228_-\|ketoacyl-ACP-synthase-III	unknown	unknown	gnl\|CDD\|236475
NC_017167.1\|WP_014462948.1\|50887_51307_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_017167.1\|WP_014462931.1\|34686_36054_-\|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|274399
NC_017167.1\|WP_041694817.1\|32333_33182_-\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_014462947.1\|50201_50834_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293807
NC_017167.1\|WP_014462930.1\|33319_34690_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340825
NC_017167.1\|WP_008337831.1\|43041_43959_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224005

Protein	Function_ID	Function_description	E-value
NC_017167.1\|WP_041695572.1\|31394_32333_+\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.36524e-68
NC_017167.1\|WP_014462923.1\|26505_28206_-\|IS1634-family-transposase	gnl\|CDD\|227708	COG5421, COG5421, Transposase [DNA replication, recombination, and repair].	2.36859e-31
NC_017167.1\|WP_041695577.1\|49613_50183_+\|cysteine-hydrolase	gnl\|CDD\|376404	pfam00857, Isochorismatase, Isochorismatase family. This family are hydrolase enzymes.	3.87046e-38
NC_017167.1\|WP_041695573.1\|41002_41590_-\|IS607-family-transposase	gnl\|CDD\|225296	COG2452, COG2452, Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair].	5.5732e-58
NC_017167.1\|WP_041694819.1\|41625_42846_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.09297e-50
NC_017167.1\|WP_049784300.1\|23414_23795_+\|IS66-family-insertion-sequence-hypothetical-protein	gnl\|CDD\|379154	pfam13384, HTH_23, Homeodomain-like domain.	0.00650247
NC_017167.1\|WP_041695576.1\|48119_49439_-\|MFS-transporter	gnl\|CDD\|273327	TIGR00895, transport_protein, benzoate transport. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	2.00936e-14
NC_017167.1\|WP_014462932.1\|36507_37791_+\|isocitrate-lyase	gnl\|CDD\|237893	PRK15063, PRK15063, isocitrate lyase; Provisional.	0
NC_017167.1\|WP_014462925.1\|28517_29870_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	3.36914e-26
NC_017167.1\|WP_041695575.1\|46661_47735_-\|BMP-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380577	cd06354, PBP1_PrnA-like, periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. The PnrA lipoprotein, also known as Tp0319 or TmpC, represents a novel family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC) transport system (pnrABCDE). It shows a striking structural similarity to another basic membrane lipoprotein Med which regulates the competence transcription factor gene, comK, in Bacillus subtilis. The members of PnrA-like subgroup are likely to have similar nucleoside-binding functions and a similar type 1 periplasmic sugar-binding protein-like fold.	9.94554e-112
NC_017167.1\|WP_014462941.1\|43995_45069_-\|ABC-transporter-permease	gnl\|CDD\|226962	COG4603, COG4603, ABC-type uncharacterized transport system, permease component [General function prediction only].	3.39825e-96
NC_017167.1\|WP_049784393.1\|24219_25806_+\|IS66-family-transposase	gnl\|CDD\|376980	pfam03050, DDE_Tnp_IS66, Transposase IS66 family. Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.	1.2593e-109
NC_017167.1\|WP_014462938.1\|39879_41031_-\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	7.88421e-68
NC_017167.1\|WP_041694816.1\|30253_31228_-\|ketoacyl-ACP-synthase-III	gnl\|CDD\|236475	PRK09352, PRK09352, beta-ketoacyl-ACP synthase 3.	0
NC_017167.1\|WP_014462948.1\|50887_51307_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	4.00795e-32
NC_017167.1\|WP_014462931.1\|34686_36054_-\|nucleotide-sugar-dehydrogenase	gnl\|CDD\|274399	TIGR03026, NDP-sugDHase, nucleotide sugar dehydrogenase. Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.	8.97406e-116
NC_017167.1\|WP_014462947.1\|50201_50834_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	8.93781e-62
NC_017167.1\|WP_014462930.1\|33319_34690_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	8.31249e-52
NC_017167.1\|WP_008337831.1\|43041_43959_-\|ABC-transporter-permease	gnl\|CDD\|224005	COG1079, COG1079, Uncharacterized ABC-type transport system, permease component [General function prediction only].	9.32665e-99

>NC_017167.1|WP_014462932.1|36507_37791_+|isocitrate-lyase
MTYFKTAAELEQHWKTDPRWKGVERAYTAEDVIRLRGSVHIEHTLAQMGAEKLWRRLHEDGFIRALGALTGNQAVQQVKAGLKAIYVSGWQVAADANLAEHMYPDQSLYPSNSVPSLVRRINNALLRADQIQTAEGKGDIDWMVPIVADAEAGFGGPLNVFELMKMMIEAGAAGVHFEDQLSSEKKCGHMGGKVLIPTSHAVRNLTAARLAADVLGVPTIIVARTDANGAFLITSDVDDRDARFITGERTPEGFYRFRGGLEAAIARGLAYAPYADMIWCETSEPNIEEAKRFAEAIKAEFPDKLLAYNCSPSFNWRKKLDPKTIEEFQEIIASFGYKFQFVTLAGFHALNYSMFELAYGYNQRGMGAYSDLQQQEFAAEARGYTATRHQREVGTGYFDEVAQVVSGGLSSTTALTGSTEEEQFVEA
>NC_017167.1|WP_014462931.1|34686_36054_-|nucleotide-sugar-dehydrogenase
MRTQIAVIGLGYIGLPLSLALCERGETVIGVDVDERKVNELRTGVTHVMEPYRGESLESILRRHLESGRFTATTSLAEAAERADTFIVTVGLPVAGDVVDKSPLLACVNDLGQALRPGDLVLIRSTLVPGMMEDEIVPRLASASGFVPGRDFHVAYAPERVAEGRAMKEFQTLDVIVAGLTDACAHRAMAVLARLTDGHLHKTSLRVAELSKVVENAQRDVNIALAHELKVVAEEHGVDVYELIRMANTHPRVHLLEPNIGVGGFCIPNAYAYLAASLTSEEHIPLFSLARQINLTAPHRAARQLDDALRQIGKRLSGARVALLGLGMKDGSNDIRQSPAVHFAEILAERGATVTAFDPTVDPYFPFQAASLEDCLVDVDAVAVAAWQAAFDTTPWPALLAVARQPLVLLDLKRRLVPSLKEAGWQIRGDSHLPYIATPAPHASAERDCAVEMVP
>NC_017167.1|WP_014462930.1|33319_34690_-|glycosyltransferase-family-4-protein
MKRRHALVICHDFPPVGGIAVQRPLKFAKYLGEFGWKVTVLTADHVYSATPDPSLLDEIPEDVQIVRVTDLVSKQLARWSGRIVGDGSTSTPQASSQARRPLWKRLAWSAWKWAQAHALIPDESVVWAMLAGFAARRIVRQRVIDCIYTTSGPQSTQLAGLIASAFSRTPWIADFRDPWTDNLHFHHRGWRASLERRLERMVFARASAIVTVTDGFWRLFAAKYPHRALDIHVIRNGVDEADFPPAPARHKGEEEPFTFFYGGILYPGRSADALFQAVHRLLQNGHITPQRLRIQFAGVLDYPGHHHHTRLIRELGLEAVIEPLGYLPRREALTRMLAADATLLIGDQSEQAKDYVPGKLYEYLYAGRPILAMLREGEAADLIRREQAGIVVPPDHPDAIAQAILHLMAQPATERRTWNPAYSRRAQAQQLARLMDDVLAAVQTESTAWSSMSWDV
>NC_017167.1|WP_041694817.1|32333_33182_-|hypothetical-protein
MALQAWFSRAAASAALVGVCAVSTACGSSAASSQWMLVNHWMIDAVTTKQAPLALQCLLIDANPTTQSVVSSAQLQTPGLHTRSFSQQELHLTQNTIEFQLHFTSTVTRSMHGAEPTLTIATPNWTHTFSFGEMDVTLVPKRVNWLLPLRSFAGESGAFTTSHVFAMVVANPLPHAVTFDGFTVGGGVELERTAYVVNPSNVFLTIPKQAKDLSAPIAIAPGQTVALYCAFRQPSAYRNVYFQPALRLTYQGQSGYELTNPALYTETKFKGDPTAIYPTVNG
>NC_017167.1|WP_041695572.1|31394_32333_+|ADP-ribosylglycohydrolase-family-protein
MIALEDRLRGGMWGLLVGDAFGEPYVGLQPEEMPPEGEIDMQGPPGEWVAVVPPGTWTDDGAQALCLLDSLLTCGRFDPADFATRLIAWHDEGLWTVDGQVFGIGWQTKLAIQEMKRGVEPERAGLVLPEGKGNGALMRVLPLALWHRGADAALVEDAHRQARVTHGHVTNQVCCAVYCLWARRMLDGQAPDEAYENAIAALRGLYGEESPYRRSLEDELCPDDPPVTNGDGYVVHTLNAARLALNETSYERVVRRAIQLGRDTDTNAAVAGGLAGIAFGASGIPERWRRQLRGRDKAEPLVESLVRWRLGS
>NC_017167.1|WP_041694816.1|30253_31228_-|ketoacyl-ACP-synthase-III
MYKAVIRGVGSYLPETRLTNVEIEQMVETSDEWIQTRTGIAERRIASPEEATSDLAYHAAVAALADAGLQPEEIDLLIVATETPDYLLPPVACQVQARLGCRNIGAFDLHATCAGFLSALQVAEQFVKSGVHQHVLIVGADTLSRFTDYTDRSTCILFADGAGAFVVSRGEPDEPGGVLATAIHADGTYFEHLYIPGGGSRTPYGEGAKAKIVMDGRKIFKLAVNVMAATAEELLQKTGRQKDEIDWLIPHQANQRIIDAVAESLDFPEEKVVSTIQNVGNNSSATIPIAVDTAIRDGRIQRGDLLMLVAFGGGLVWGGAMVEY
>NC_017167.1|WP_014462925.1|28517_29870_-|IS1380-family-transposase
MNHLRFIIEESDEVIVTHSGMTLVGVLLDKTRIGERLNQTRLPGMGKPDISNRDVAYSYIGLLCQGKTDFDHIEAFRDDEFFMIALQVDNVPSSPTLRQRLDMVAGKSGWESILREESARLLRALDVTLHPIELGVPAERRTYIPLDIDVSPFDNSGTKKEGVSRTYKGHDGYAPIFAYLGQEGYVVNVQLREGSTHVQKGTSTFLRESIQYARQVTDLPLLVRLDAGNDSAENIAVCRSQDSRAEFIIKRNLRKESPEAWLVIAQRHGTCHEPRPGKKVYHGSLMCPVKGVSEPVRMVFEVIERTTTADGQILLVPDIEVSAYWTSLPDDPAVIIHLYHDHAVMEQFHSEIKTDLDAERLPSGKFATNNLVLHFVCVAYNLLRVIGQESLKRNDAPLRKKAERRRIRTVIQNLMTLAAKMVRHARQTKLKLGYGNRWLPAFRRLYLAFA
>NC_017167.1|WP_014462923.1|26505_28206_-|IS1634-family-transposase
MREAFQLFGPVRSYVMGPAPVLARLIDELKWVEIIDEFVPRPDSKLSIGLRTKALLVHIGTNREALYRVEEFYAQRDVEVLLGNGVSADDLHDDALARALDALYDAGLEALYARIALHTLRRLRVLSDSNELIPIHADTTSLSVTGEYLDQTAFRIDRGFSKDHRPDLKQIVFGLCTVHGLGLCANVNPGNLDDHTWNFENIQQLLSQLDEETRKRSVYVADAALVTKDNLELLAEEDIHFISRLPGTYKLSEDLKRAAWEKENSWKEVGRLAEAEDSAHYRIQAFRRTLYGRTYRFVVVRSSSLDTRKERKLEEVLKREKAALEKAAKAMNQNVYSCEQDAQMAMQTFMHEHRATLHPISARICAEQVQEKRARRGRPRKDDPPPPVHTQYRVEVEILPPSEERVQQWREKEATFVLITDIRDDQRVSDEQILRLYKEQHEVEARFRYLKSPYHVGPIYLHKPTRVKAFGFVMLLSLLLYSVLEYLIREKMKRETEPLMLPGKRKSFRPTGLAILEMLDGMTTVHMQVGDTWQRVPATPHNPQIMRVLKLLNMDLSIYTEAQKTA
>NC_017167.1|WP_049784393.1|24219_25806_+|IS66-family-transposase
MNTTTDTLNQLETLQARCEAQEKEIAELKKQVKLLLEQLRLARHRQFGKSSERTTDDQLRLDLVFNEAEAEAQPEEEEPTFEMVTYQRRKKQPGQRDAMLADLPVERVEYRLSEEERICPCCGDVMSEAGVEIRRELIHIPAQTKVREHVQQQYACRTCDQQGTETPMVKAQMPKPPIPGSLASASMLAYVIDKKYVDGLPLFRLEQQFARQGLQLTRQTLANWVVLGTTRWLELMYNRLHEELLKRRYLHADETTLQVLHEPGRSAETTSYMWLYRSGQDGPAIVLFDYQETRSKEHPRRFLEGFGGYLHVDGYSGYHDIPGVKLVGCWAHARRKFHEAHTALPAEERKKPTAARIGLEYCNRLFKIERALKDMDPEQRHAQRQKLSRPVLDELWHGSGRRANRYCPRVPWGQAVSYCLNQWPKLTVFLEDGHLELDNNRSERSIKRFVIGRKNFLFANTPRGARASAIAYSLVETAKENGLDPYLYLEYLFERLPNIQTDDQTAMNDLLPWSDHLPDGIRRRTKKA
>NC_017167.1|WP_049784300.1|23414_23795_+|IS66-family-insertion-sequence-hypothetical-protein
MIPLESIDGGITVTKAELEKLRELWRARVADFRASGLTGAAWCAAHQVKEHQLWYWVSKLKTEGHYGDHQHGDTDPRFIPVRVGEPSAEGSDKPLSVRVGPVVIEVTPGYDTELLRDVVRTLASLC
>NC_017167.1|WP_014462938.1|39879_41031_-|transposase
MKIHRAYRYELAPNRMQRSLLAKHAGAARFAYNWGLARRIALYEETGQSTNAIEQHRELNRLKKTDFPWMYEVSKCAPQEALRDLDRAFQHFFRGLKEGRRVGFPRFKKKGRDDSFRLTGSIRVLDNAIQLPRLGRIRLKEKPHVEGRILSATVKREADRWYVSLSAETEIPDPVPPSGEPVDVDLGVSWFLTLSDGTKIEAPKPLARYLRRLRRLSKRHSRKKPGSRNRRKSALALARLHRKIRNIRQDFLHKVTTELAKTKRVIVIEDLHVRGMVQNRTLARAISDVGFGEFRRMLTYKCTWYGSELIVAPRFYASSKTCSACGYVISELPLSVREWTCPACSTRHDRDINAAKNLLRIGTASSAGSDACGDPSGGAALGC
>NC_017167.1|WP_041695573.1|41002_41590_-|IS607-family-transposase
MKLSDWARKNGITYKTAWRWVKEGRMPVPFEQTPSGTILVHEPESSTENAVALYARVSSADQKADLDRQIARLMEFATEQKLVVVKAVTEIGSGLNGHRPKLMKLLSNPDAHTIVVEHRDRLMRFGFEYVEAALAAQGRRILVVEPGEVKDDLVQDMIEVLTSFCARLYGRRSARHRAKRALEVFKREDSSGVSV
>NC_017167.1|WP_041694819.1|41625_42846_-|MFS-transporter
MRTYGWFQRRSLALLMVADGISVLGDQVGWMELLWSTMTLTKSAQIMGWLGLAFGLPTVALGPTVGHVLDHTSHKRVLITSQVMLGALFASIAVLQRMHALPVWALLMFAIAAGCLTPFSTIGWSVVIPNIIADDELGSVNALMEILWNGASILGPALGGFAIARVGSSAALFADAISFWLAALCVGMAKVPAQSMHAPITLPESARLFVQNTLEAMKTLYALRPVWWITIGAWVLNLAYGALDIELPLLTHRQFGRGAWILGSLWTTYAISSIAGAAFSGWISKRRRIGVVMTMMIVGWGAAFAPLFWTHAFTLTYVFLACAGLLFGGYPPLARTVVQRSVPSQVMGRIMGLRGSLIALGPPLGSWVGGVLDRWLSPSDAIALVGMAVVALGCWLGSRGRELLIE
>NC_017167.1|WP_008337831.1|43041_43959_-|ABC-transporter-permease
MVFSNPEIWALTLSMAIPLALPAVGGTFSERTGVVNIAMEGIMLIGAFFGVAFSYWTGNAWIGLLAAIVCGALTALALAWGAIHVSADQTVLGMGINIFAAGLTTFLLNTLFGYNGTPVNTPKLPSVSIPGLDRIPYIGVIFTNQSVLVYIGIVLIFLSHWFLFSTRLGLRMRSVGENPLAADTLGIPVWRLRYLGVVLSGVFSAIGGAYLSIGILNGFTSNMTSGRGYIALAAMIFGKWTPLGSFGAALIFGFSTALGIVLQGHGVSSNILQMIPYALTILALTGLIGRSTPPAADGIPYEPRR
>NC_017167.1|WP_014462941.1|43995_45069_-|ABC-transporter-permease
MKALQSILLPVAASLVAIVIGAILVAALGYNPVSVYGSLISGAFGSLGNLGNTLTASLPLIIIGLGIALSFQSGLFNIGADGQYWIGATAAVWVGYHFTSLPGWLHMLFCLAAGMIAGALWAGIVPGLTKAFVGAHEVITTMMMSYIAILFARYLIEGGPMQEKGYIPQSPLIASNTQFPYFTQGFARSQLSPISILIAALAVIVAWFLLYKTTLGFSLRSVGLNARAAKYAGIRVKLHIVIALALSGLFAGLAGAVQMLGVDHQLLDGFSSNYGYTAIVVALLARNNPLAVVISGLFFGALTTGGQNMQIVSNVPASLTNVLTGLIIFFVGCERIIPQVIGWYRRRRSARAQTPAS
>NC_017167.1|WP_041695575.1|46661_47735_-|BMP-family-ABC-transporter-substrate-binding-protein
MQKRIWQSGLSILAAAALVVGCGTNNSSSGTTNTANSGGTGNTTSTSGKTIKVGLVTDTGGLNDNSFNHLAYVGMQEAQKELPNIQTSVVQSQSESDYVPNLSHFAQDGYNLVIAVGYLMADAVQQVAKEYPKTHFLIIDDSITGIPNVASAIFQSQQAGYLAGVVAGMVQKDHLLKNINNHNTVGVVGGQEIPPVDTYIAGFQQGFHSVDPTGKVIVEYTNSFNDEAAGSQYAQNEISQGADIIFPVAGGTGIGSIKAAQSAKVYAIGVDTDQSYLAPGTVITSAIKRVDTSVFDTIKAVQDGTFKSGVNNFDLSNNGVGIAPLISGLPKSVTDAVNQAKQEILSGKIQVSTTVQK
>NC_017167.1|WP_041695576.1|48119_49439_-|MFS-transporter
MSSAPQTVRDEHWTRTDSWLFWSFGLGMLLENYIFSLSSVATQWVPMPKSLQSLLLAWSPIWLIIGIAVAGPLADRVGRKNTFYTTMALYGLGAIGLVFSNQYALILLFLAMLLFAAGGEMNTIMAVSHEMMPHKHRGKTMMLELNFINLGGVILGLVALSTAYQHVAFQRAMIALTLLVVLVILFFARRNTPESIRWLERTGQHDRARAEIEKFYGFEEYQARQEAARRSTQAAQASDASRAKRVGLKLFTTLTISFAGSAGFGLMTYVLGPHFFPKMNAAIILVATGTGFVSGFFGLWADRWSRKSLLLIGYLGSFVMTLVIWATIPAWSKSLALFWLLLVVLNVFVNIGYLTEDTLKGEVWPTQLRGTYTALVRFISIGLYIATIYITQNFGITAYTMFNALVWAIGLAGAVAWWIGGYETGKGTSLDVASGELDT
>NC_017167.1|WP_041695577.1|49613_50183_+|cysteine-hydrolase
MTVDVKHTALLVMDVQNGIVSRYIQDASAMRPFQQAVSAARKAGMQVIFVRVAFSEGFPEASPRNKMFAHLAQAGNMTVSADTTQIHESVRPEPGEPVVTKYRVSAFAGSNLEVILRAKDITHLVLCGIATSGVVLSTLREAADKDYALTVLKDACLDADPEVHRVLVEKVFPRQADVMTVEEWAKTLA
>NC_017167.1|WP_014462947.1|50201_50834_+|MBL-fold-metallo-hydrolase
MEIAPKIHLLECTKGSYSYLVLGDEPVLVDTSMPGRADEIVKALASLGLKPGHLAHIVLTHLDVDHIGNAKRLKELSGATLWAPAPDIPYIEGTAKPKGVRRAIAGLMRVERPKVDRALEPGAHVGGLEVVPAPGHTPGHVCLIARDTLLAGDLVTTRGGRLKKSPSFLTWDKAALKKSLADVGRLSFDWVCPAHGDPVRRGSLWEALLE
>NC_017167.1|WP_014462948.1|50887_51307_-|acyl-CoA-thioesterase
MIHETPIHIRYSDTDLNGHVNNAVYATYMEESRISFLQEVFPGQRLPLVIASLHIDFRQETRYPEHTDVIARTWLTRLGRSSFEFFCQIVSVRGEVMCEGTAVVVHYDFEKRKSAPLPDWAREKLLPYVREREESNVGV

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Crispr_ID: NC_017167_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017167_2

341074-341171

Orphan

Consensus_repeat	Method
ACGGTGACCGATGCGAACGGGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017167_2

>merge|NC_017167|2|341074-341171|CRISPRCasFinder
ACGGTGACCGATGCGAACGGGAATCCGGTGCCGAATCAGGTCGTCCAGTTCTTGGTCTCGACTACGGACAACCTGACGGTGACCGATGCGAGCGGGAA

>NC_017167|2|2|341074-341171|CRISPRCasFinder
ACGGTGACCGATGCGAACGGGAA	TCCGGTGCCGAATCAGGTCGTCCAGTTCTTGGTCTCGACTACGGACAACCTG
ACGGTGACCGATGCGAGCGGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017167.1\|WP_014463237.1\|353229_354081_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_017167.1\|WP_041695629.1\|325725_326541_+\|transposase	unknown	unknown	gnl\|CDD\|273806
NC_017167.1\|WP_148260095.1\|344936_347981_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_158306708.1\|348066_349527_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133005
NC_017167.1\|WP_041694883.1\|354312_355188_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|274042
NC_017167.1\|WP_014463230.1\|344287_344710_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_014463239.1\|355184_355931_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_041694876.1\|339206_339893_-\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
NC_017167.1\|WP_014463218.1\|322397_323510_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380650
NC_017167.1\|WP_193352812.1\|328781_330476_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NC_017167.1\|WP_041695628.1\|319516_320728_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NC_017167.1\|WP_014463234.1\|349614_350814_-\|DUF87-domain-containing-protein	unknown	unknown	gnl\|CDD\|224588
NC_017167.1\|WP_014463219.1\|323585_324368_+\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NC_017167.1\|WP_014463220.1\|324369_325575_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226669
NC_017167.1\|WP_014463217.1\|320879_322052_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|119353
NC_017167.1\|WP_041694878.1\|342261_344301_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_041694874.1\|330552_331056_+\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|238207
NC_017167.1\|WP_158306709.1\|352472_352694_-\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_041694875.1\|338658_339210_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_014463235.1\|351068_352277_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367101

Protein	Function_ID	Function_description	E-value
NC_017167.1\|WP_041694883.1\|354312_355188_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|274042	TIGR02224, Tyrosine_recombinase_XerC, tyrosine recombinase XerC. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerC, one of two closely related chromosomal proteins along with XerD (TIGR02225). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and homologs of XerC on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerC, as some apparent XerC examples score in the gray zone between trusted (450) and noise (410) cutoffs, along with some XerD examples. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	1.24986e-51
NC_017167.1\|WP_041695629.1\|325725_326541_+\|transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	1.24917e-05
NC_017167.1\|WP_014463237.1\|353229_354081_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.25079e-10
NC_017167.1\|WP_041694876.1\|339206_339893_-\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	3.28363e-56
NC_017167.1\|WP_014463218.1\|322397_323510_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380650	cd19995, PBP1_ABC_xylose_binding-like, periplasmic xylose-like sugar-binding component of the ABC-type transport systems. Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	1.66236e-127
NC_017167.1\|WP_193352812.1\|328781_330476_+\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NC_017167.1\|WP_041695628.1\|319516_320728_-\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.50209e-65
NC_017167.1\|WP_014463234.1\|349614_350814_-\|DUF87-domain-containing-protein	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	5.38317e-20
NC_017167.1\|WP_014463219.1\|323585_324368_+\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	4.35688e-106
NC_017167.1\|WP_014463220.1\|324369_325575_+\|ABC-transporter-permease	gnl\|CDD\|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	1.31661e-99
NC_017167.1\|WP_014463217.1\|320879_322052_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|119353	cd02874, GH18_CFLE_spore_hydrolase, Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the forespore inner membrane and is deposited as a mature enzyme in the cortex layer of the spore. As part of a sensory mechanism capable of initiating germination, CFLE degrades a spore-specific peptidoglycan constituent called muramic-acid delta-lactam that comprises the outer cortex. CFLE has a C-terminal glycosyl hydrolase family 18 (GH18) catalytic domain as well as two N-terminal LysM peptidoglycan-binding domains. In addition to SleB, this family includes YaaH, YdhD, and YvbX from Bacillus subtilis.	5.71918e-130
NC_017167.1\|WP_041694874.1\|330552_331056_+\|glutathione-peroxidase	gnl\|CDD\|238207	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per subunit, which is involved in catalysis. Different isoenzymes are known in mammals,which are involved in protection against reactive oxygen species, redox regulation of many metabolic processes, peroxinitrite scavenging, and modulation of inflammatory processes.	1.64305e-102
NC_017167.1\|WP_158306708.1\|348066_349527_+\|glycosyltransferase	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	3.86342e-36
NC_017167.1\|WP_014463235.1\|351068_352277_-\|hypothetical-protein	gnl\|CDD\|367101	pfam02486, Rep_trans, Replication initiation factor. Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family, including myelin transcription factor 2 and cerebrin-50.	9.6487e-05

>NC_017167.1|WP_041694876.1|339206_339893_-|YigZ-family-protein
MTSFMTLAGVWTDEIVEKKSRFIASAVPVRTEAEALAALERVRDEHRDARHHVYAYRIGIQVPHERFSDDGEPSGTAGRPVLEVIRRKDLTNVLVIVTRYFGGILLGANGLVRVYTEAAAVVLERAPKLVCAQMCDILVTCGYEHYGRLLHLLEQTGLRLYDAEFTDVVRFRLVVREADVPRTVALVTDATSGQATCDVRPPAYVGITDAGELVRDVWLPEHDAPRQT
>NC_017167.1|WP_041694875.1|338658_339210_+|hypothetical-protein
MFILPEPNHHPMDNVPVHTEADAPTMGEIARHITAFVPVYCQGNRTLVLLANGSMFYLPRRAQWVRETLLRHFAISHRDLRRACEEDLNRSLFAPVVIPAAGLAYAQLRVRTPIGRNDGAQGFFRIDAIRGVRAINTEETAVRMEGGIDFMVRMPRPRVVERVLGARSALILQLARGVAYPRF
>NC_017167.1|WP_041694874.1|330552_331056_+|glutathione-peroxidase
MTLTIYEFEVEKADGTKISMREYQGKVLLIVNTASKCGFTPQYEGLQKLYELYRERGFEVLAFPCNQFGNQEPGSNEEIQTFCSTTYRVTFPVFAKIDVNGPNAHPLFEHLKKEAKGALGSETIKWNFTKFLVDREGRVVKRYAPQTSPESIREDIEACLVHASRGQ
>NC_017167.1|WP_193352812.1|328781_330476_+|2-isopropylmalate-synthase
MKHVNKYTRQYFLPPKPCFDWVHRDYLDHPPIWCSVDLRDGNQALIVPMNLEEKLAYFQLLVEIGFKEIEVGFPAASDTEFEFVRTLIERDLVPDDVTIQVLTQSRDHIIERTFEAIRGAKRAIVHLYNSTSVAQREQVFRADKDEIVNIAVTGAEQIRDLARTTPGNFFFQYSPESFTGTELDFALEICNAVLDVWQPTPDRKVIINLPATVELSMPHVYASQIEYMGKHLARRDAVILSVHPHNDRGTGVAAAELAMLAGAERLEGTLFGNGERTGNVDIVTLALNLYSHGIDPGLDFSNLPAIQARVEALTKMQVSRRHPYAGELVFTAFSGSHQDAIAKGMKWREEKSPEHWTVPYLPIDPKDIGREYEGDIIRINSQSGKGGIGYVLEQSHGFDLPPKMREQLGYAVKRVSDREQKELSADEIAEIFMREFVNLGQPLDLVELTGTDAKGSHRVRATVVWQGETVEIEGAGNGRLDALCHALEEGLGIRVANLTYKEHALEVGSGSRAVAYISVDDEEGNTHFGCGVDTDIMEASAKALVSAVNRMLAHRPEIAVPVSK
>NC_017167.1|WP_041695629.1|325725_326541_+|transposase
MDIPRNANDLVAKHLTLALPGEVLSVIGVRDAPVVRALATEIPEVRMRQTMTDIMLELADGRLLHLEFQSTKEPMLYRFAAYDVALVERHRRAVRTVVLYTSEVQSAPSELDAGSFRYTVENVYLGQMDGDAALETVRRHLETGEWTPEDRVRLAFAFHMRFDRRTRDEAFDAIVETLQRVPDREEQNYLAALVFGFSARVLTDEQKAVLRRVLAMTELLKEIVEEAKDERSKEIAERMFRKGASVADVVELTDLSEQEAQEVLKRVREEA
>NC_017167.1|WP_014463220.1|324369_325575_+|ABC-transporter-permease
MTVNIGQAKQTQTPAARSTSVFDRIIGGEFQQLPVFLSLVLIWIVFEILNNSFLTSRNLSNLVLQMAEYGLLGVGETLILLLGEIDLSIAAVSAIGGAILAVLAGNGVNPYVAILAGALSGTVLGFFQGFWVTVLRVPSFIVTLAGSLAFLGLLFVLIGQEGTVPIMNNTINAIAGNYLPDWLSWVLVAVALLLMVWTAVRDRAKRQKLGLPPKSAASTWTKLILSAAVMIGATVLLNAYQGVPIAGLVLIVFVVLLAWICQSTAFGRHIYAVGGNAEAARRAGISVKGVRIMVFTLAGTMAAIGGIVGASRLGAASTASGGSDLLMDSIAAAVIGGTSLFGGYGSVWNALLGALVIGSIENGMALLNAPTSTKYLVEGAILLLAVTFDTFTRMRRKQLGR
>NC_017167.1|WP_014463219.1|323585_324368_+|sugar-ABC-transporter-ATP-binding-protein
MATEVKTQPVLEVRNLRKRFGAVQALDGVSFSVHAGEIVALVGDNGAGKSTTIKMIAGVEQPDEGEILFEGQPVRLTSPAVAERYGIQTVYQDLALCDNLDIVSNLFLGRELRRSVIPGLVRVIDRNEMERRAIPVLNELGIRLPPLHTQVASLSGGQRQTVAVARSVLWGSKLVMLDEPTAALGVVQQRAVLELIQRLAASGRAVLVISHNMSDVFKIANRIVVLRLGRTVATFEREQVTPEQVVAAITGASAQEEVTS
>NC_017167.1|WP_014463218.1|322397_323510_+|sugar-ABC-transporter-substrate-binding-protein
MAKKTWKKSATWMAAAAVVTGIVAGCGTSSTNAQSSTSTGAASAVNPHPSVKIAFLMPETNTSPRWEYDDRPDFIAAMKKLDPNAQIIYANAQGSEATQLQQVESAITEGAKLLVVAPVNGFAATTIVTEAAKAHVPVISYDRLIQNAKVDYYVSFNNVEVGKLQGEYIAQHTKKGGTVVMLDGAPTDPNAKQFAQGAHDVLDPLFKSGKLKLGYEQFTPNWDSQQALTEMQQALTRLHNHVNAVLAANDNLAGAAIQALEQQHIKGIPVTGQDATDAGLHRIYYDGTQSMTVYKPIKEEADAAAQLAYDLITGKKPPASLVNGTVNNGATNVPSVLLQPIVVTKSNIASTVIKDGFTTWARIKNPAEQQ
>NC_017167.1|WP_014463217.1|320879_322052_+|LysM-peptidoglycan-binding-domain-containing-protein
MLIHVVEPGDTLWELGKLYHVSAADIAAANGIRNPEQLVVGQALVVPTREGVVTGAERRTIEVNAYFVQFTDPAPHQLDVLAPVLTYVSPFSYEAETDGSIRARSDDTALVDAALHQSVMPMLVLTNWHGDMFNSDVAHAIFTSPSTQEKILTNVLRVMGDKGYRALNLDFEYVYAHDRDLYNAFVERCAERVHKEGFLLSSALAPKLYADQPGLLYEAHDYHWHGEVCDFVILMTYEWGWIGGPPMPVSPVDQIRKVLDYAVTAIPRDKIMLGVSVYGYDWTLPYRPGTRAATLTPVQAVNLAYQQHVPIQYDLRAEAPYFTYSDAQGRHHIVWFEDPRSFQAKQDLVVEYNLRGMSFWSYPTNFPQVPILVNNQFNTKKWTREDVPVR
>NC_017167.1|WP_041695628.1|319516_320728_-|MFS-transporter
MATVPENGPSPAPPLSRRLVLFMAVAAGVGVANLYYLQPLLHEIQVGFHAASWQVGLAATLTQIGYALGLFLFVPLGDSLERRSLIVRMCIVTAGVLLILAASLNVWWLVSSCLVVGAATIVPQLVVPFAAHLAPPEERGRTVGTVMSGLLIGVLLARTLAGLVGQALGWRAVYVLAAAAMMGLAALLRASLPLSPPESRTPYGRLLLSLLHLIRAYPDLRDASLLGAMSFGAFSAFWTVLSLYLAGPPFHLGPGVTGLFGLAGVAGALAAPYAGHVASRLPAIWTARLASCLTLASFGLFWTFRHSLAGLALGVVLMDLGVQATQVSNQARIYSLSDEARSRVNSVYMVTYFLGGALGSFVGASAWDRFHFGGVCAAACVLLAIGILGVAMVAPSRLRDAIR
>NC_017167.1|WP_041694878.1|342261_344301_+|hypothetical-protein
MPSDLTLLPVLGSSNGAMQVSWEPGQSVGALGLSNHALQASYADVSQIPNNPQGLEETASSSETMYFGAYTESGQEILPAQFPDDQLSFNLNVPQGFTMNSAFGFQLDPAGSGDSTVYNAIVKQLQSNYGYKTDGTQTFDITNLSVYVDYKTNQIYVDSVQGYLYSNLQSATGTPFTITFGQGENTSVTAKLNTNYTVAVNSSNDPNSSININGGTATLNINVQVNNPDANPVGQGGASASANIQFQPGSGVSALGEATTIEGIENYGPLINTNSGTPNTISLQGIPWGNNQSQYFLQPSGEVTWLVAPFNNYVNLASIPNGGLNYTIASDGKNQDSINFIDGHEISNSKYNYSAQVVISKSGKTTVNGQVIFDPSAYGLQTVVAYTPDGNYILGQDSSGNYVLYDTQTGKQVADFGQVPMPADAQGDPMIVGGQVSTTSGGSGTLTLTWISGNGQSKATGTATNATETVSDELIPIQIVEVGAYGRFTGTYTYTATENGQTATAQVTYTSASTGSVQAVYATPQNITGSADQTNTVTLEAQDAFGNPVPNATITITPQNLPGVWITAVNGVALQQSVPQGNTSQTEPTPVPLFNPADILPSGWQLDYNSISVPGALAATNIGSGQVPTITLTTNNNGEVQLTLEDGAVTYAAVNTTKGTGQKCDVPTDYRTVSPGVGW
>NC_017167.1|WP_014463230.1|344287_344710_+|hypothetical-protein
MSGGELNAYSAGGTTAIGAVPINWQGTETLQGSNGNSNSNGNSNNGGSNNQQSTLISNASASYALGLTNVKATVASGVTSVQIIDVTQNNNSLQTAQVSNGQVDTYVVGANAGDTLELVPYEGNTAESNAAVTVTVQQAE
>NC_017167.1|WP_148260095.1|344936_347981_+|hypothetical-protein
MAKRNKSMRKMNLATAAAVASMLSAMTGGTAYAATVNSQAQSTGYYINGDFFNASDVLSNPSELAELNNLLAQNPTGLYLDLNGQIANYAGFIQYVQQNHLSASNSVFDAYAQANPFTIPSTATLVTPSGNAPYYEQTISAVNSSVGVFPSSITDGQAFTMTVTVNDANGDPVSGLSASSFVLNVNGKFVTASAAVYQGNGTYVLTFLPTTLTPGPDESEALVVDGTTVATSVGVDVSAGSVSTSGSTAVFPSNSVLDASGTYTVTVNLEDAIGNPISGATGTPTVSLGTGANAIPLTATALKAVTSTPGEYTFTFTAPTVSVSTALPLVVNVDGVTLTSTQTYTVTSDTPTALALESSLPATLEDGATYTVTVGAVDANGELVPTTSLATTTTSWTVEFAGNSATIKSVTTASTPGEYEVTFQMPSVTAGYVSKLTISDTTNNLSLTTSNSYTAGAGISSAASSVTWPSTTTLVEGQSYTVTVDVVDTSSNPVTGLTTSDFSITGPSTTIESVTPGSTSGSYVVTFELTTTTPGTLDVVVDGTTITSSPLTVTSVESTSVSAVTLSTLDGATASSVSAPVLLPGSSNTVTLDAGAVNLTSSDFSVELGNTPLSVTSVEPATTAGYYTLTFTAPNTTVSTPETLTFTVGTATTSINDVTVENNISATASTVVSGGPSTTTWTEGSTATFTVNVENASGDPVLGLPTSTFDITLGNSSNLVTSVTEDGGSYTVTVQAPNTVVTSATFSVSVDGVTITNGVPTSSYNVVASEPATFNSSVTFPSGNALHELIAGQTYTITATLDNAQGNPVLGLTTSDFALGYTTSSVTTTNGADTLPELPTSSFAVTGNSNGTYTITFVPTSASSSAEYLALLVDSQGVTTKGSSVSTSTSGAVFGDSTSLSVLPGAPEQLAVTAATATVSSTNSPDAVTVTLEDAYGNPITSDSSDVVTFSLATGSATGATLSATTATLSSGTASVTVTTPASSSDWGTGSSITVDASVTVNGHTYTGSVTIDE
>NC_017167.1|WP_158306708.1|348066_349527_+|glycosyltransferase
MVSDEVIRQKLLDGAFDEARKLALEQIKGVSWRAQSWVFLGEACLRLGNGKIARRCFERAWLLDPMAPWVNAVMKACDEVSAGKRDREVESALRVPKTTVSALVLFRDDARTIKRCIEALRPAVDEIIAVDTGSTDGSDVIASAFGAQVYRFEWTGDFAAARNFGLSKVTSQWVIAIDSDEILYAEDVDAIRTIAGVFESVRKESPVILRIVQMNLTGETVTPATSQSRMFPTGEDIEWRGLIHETPTLTKETARPAVRALVRIRVYHDGYDPKHVDLEKKFRRNLELLTEALEREPNNPVYEFYIGRESLFLKDYTKSIEYLERAEQHAKEIAGFSLLPDIRRRLAQAYMLAGKNEHMANKLEDMVKEHPEYPDGWFLRGEKKLREAGVLLQEAAQDFAKAQEAAQKYRGITEYDTAIGLWKAPAQLGEIARMRGNLVEARRWYQRVLKQEPNLKTIRERLEKLEQEACAIAQDVQEATKNTKDE
>NC_017167.1|WP_014463234.1|349614_350814_-|DUF87-domain-containing-protein
MAIHVTHGPEHWRWVEWLLGAGAVLVAYVAWTGWIDRNRLIVDAFSFEEALRRADLWDNPRYKRPSLVRVKERANGDVELVVQGLPASIWQKPEIADPFCASFGVERFRSVTQDPKRRDRVHLVLASGSLDQVVKAAGREPGTRRLPKPKVKRDRDDEDAHPAARMSFLLGYGHDGRVFWQTPVWPHLLVAGSTGSGKSTLIRLIMQQALDRDWLVYLIDPKGGVDYLELLTWLAEPMKEFPQDALPLLETLWAKHRERLTKLKEAGVSSLREAHQQGLLLEEKPILLVVDELSIFSSNTGGKDEKEVRVRAHTYLERFALASRATGIALLLSAQYPTAEILGSQIRQQVWRICGRVDDEVASRTILGVPGAEKLPPDKPGRFLYVEHGELKEFQVTLP
>NC_017167.1|WP_014463235.1|351068_352277_-|hypothetical-protein
MWVEDHTTVFREFIQTLRRFRDEQAPDGQALPFYGPHLVYDAASTVGRWLAFRSWAKEAEGMRIRWRVYETEPPRKSNLWPIEVIFGSMELWAKPFRDWWQDVKQTLRWIADAPHKLYTFDGEWCVGSRVSRLDWAIDSDEWAFVPEDLPRFVTRSRMTDQHECEVEWLEYVQETPEVSHAVNRQFTGFSFGKSPVHVRIYDKHYELFASRKPAKAKFFLRLWEQNGWTGVPVWRVEIELRREVLHQMRYGARTFADMEADEVVAHFPVTIQYWFFQWMSLRQPTEDPNRSRWPLDAKWQRVIEAVSEDPDLFERVLPGPAFDVQSLARQQRTLLAKWALVRGLPPEACVTDAYLGQLAEALHLSPMQFLLSTEKEMHLLAGRHGARLPTLQDNKVWAKVVQ
>NC_017167.1|WP_158306709.1|352472_352694_-|hypothetical-protein
MSVSEAADHSRVFAEVGDPVLLTRFRFVLPVNTGIEAGDKVDLEVRNIRVSKTGSLMFEGQLHSRKPAEAPKA
>NC_017167.1|WP_014463237.1|353229_354081_+|helix-turn-helix-transcriptional-regulator
MARVPKQERVSDEQKKMFAQWLRQFREARGWSQTELARHLGVSLAYYNSLENANKTATRRKLYDIAQKLGDVRIIAQLFGKDVLERFQREHEARMVLATSHPDSPYEEVPIDPLLMWWGFSPRARVRLMRYSEWKREPFHGQLFYVTEGPLEEGSFYFANLQERTPQLESVASVLIRYFDLACDREMQLLDLDLSQMKKIPLYEGVRRLYVAIQVYESLDDAEEVHRRFTPLMTPRIRNLDVHAKRQVNLLAGYLSAVQAASPPPHAATGETSETLEPFVATP
>NC_017167.1|WP_041694883.1|354312_355188_+|tyrosine-type-recombinase/integrase
MLGEEAITEFGAHLLRQGRSRKTVIGYQSDLRGFAAFYAKRHNLPWVVEETTVEDLRAYLDAQPAQAPTLNRRLYTFRSFFKYLVRQGVLTSNPAEMLEAKRVVQKERYALPADELARFIHHIPHPHVQAAAWTMAYTGLRMAEIIFLRMMDVDFEEGVVRVEHGKGDKPREVPISDALRPILSQYVEQYRKGAKPHERFFATPSTGGLSPTHINRVLKQTSQALGYRRYVTAHTFRHSFASNLIRQGVHITLVQKLLGHSSPTVTSVYTHATRDDLYRAVQTLSFEEGQA
>NC_017167.1|WP_014463239.1|355184_355931_+|hypothetical-protein
MTLRPEDVFQHLADGKTRDEIAQMYGYKARRYLDQFMMRRGYQWSVERETYVERVTPKKKRRGQKVARVIEAFQAEPYGDPKRIAEALGFASAFEMAQYMQAHGYLWSNTARNYVAQDRTQDEVSPSTEADSPRQAVSNEGESASLPLGDALEILGMLVKHRAKLERLLLHTEQGATDVPRYTIPGLSVVKSLHISVELDRLLRSASQAWRMSQREILEAAVIEFLRKHGYDEVLHRLLTGRKQERTS

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Crispr_ID: NC_017167_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017167_3

356765-356862

Orphan

Consensus_repeat	Method
ACGGTGACCGATGCGAACGGGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017167_3

>merge|NC_017167|3|356765-356862|CRISPRCasFinder
ACGGTGACCGATGCGAACGGGAATCCGGTGCCGAATCAGGTCGTCCAGTTCTTGGTCTCGACTACGGACAACCTGACGGTGACCGATGCGAGCGGGAA

>NC_017167|3|3|356765-356862|CRISPRCasFinder
ACGGTGACCGATGCGAACGGGAA	TCCGGTGCCGAATCAGGTCGTCCAGTTCTTGGTCTCGACTACGGACAACCTG
ACGGTGACCGATGCGAGCGGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017167.1\|WP_041694883.1\|354312_355188_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|274042
NC_017167.1\|WP_041695631.1\|362119_363319_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NC_017167.1\|WP_041694885.1\|359591_360404_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_014463254.1\|370232_370889_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|224482
NC_017167.1\|WP_158306710.1\|358425_359559_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_014463230.1\|344287_344710_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_014463239.1\|355184_355931_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_049784310.1\|370904_372494_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NC_017167.1\|WP_014463251.1\|367269_368895_+\|IS66-family-transposase	unknown	unknown	gnl\|CDD\|376980
NC_017167.1\|WP_148260234.1\|360463_361660_-\|DUF87-domain-containing-protein	unknown	unknown	gnl\|CDD\|224588
NC_017167.1\|WP_014463234.1\|349614_350814_-\|DUF87-domain-containing-protein	unknown	unknown	gnl\|CDD\|224588
NC_017167.1\|WP_049784330.1\|366531_366864_+\|transposase	unknown	unknown	gnl\|CDD\|379154
NC_017167.1\|WP_158306709.1\|352472_352694_-\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_014463237.1\|353229_354081_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_017167.1\|WP_148260095.1\|344936_347981_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_148260097.1\|356121_356718_+\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_158306708.1\|348066_349527_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133005
NC_017167.1\|WP_041694887.1\|363616_365440_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|226355
NC_017167.1\|WP_014463235.1\|351068_352277_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367101
NC_017167.1\|WP_049784400.1\|366917_367220_+\|IS66-family-insertion-sequence-element-accessory-protein-TnpB	unknown	unknown	gnl\|CDD\|377551

Protein	Function_ID	Function_description	E-value
NC_017167.1\|WP_041694883.1\|354312_355188_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|274042	TIGR02224, Tyrosine_recombinase_XerC, tyrosine recombinase XerC. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerC, one of two closely related chromosomal proteins along with XerD (TIGR02225). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and homologs of XerC on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerC, as some apparent XerC examples score in the gray zone between trusted (450) and noise (410) cutoffs, along with some XerD examples. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	1.24986e-51
NC_017167.1\|WP_041695631.1\|362119_363319_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	4.6338e-20
NC_017167.1\|WP_148260234.1\|360463_361660_-\|DUF87-domain-containing-protein	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	1.49583e-18
NC_017167.1\|WP_014463254.1\|370232_370889_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|224482	COG1566, EmrA, Multidrug resistance efflux pump [Defense mechanisms].	1.18836e-26
NC_017167.1\|WP_014463237.1\|353229_354081_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.25079e-10
NC_017167.1\|WP_041694887.1\|363616_365440_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|226355	COG3835, CdaR, Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms].	2.43197e-18
NC_017167.1\|WP_049784310.1\|370904_372494_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	5.12249e-113
NC_017167.1\|WP_014463251.1\|367269_368895_+\|IS66-family-transposase	gnl\|CDD\|376980	pfam03050, DDE_Tnp_IS66, Transposase IS66 family. Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.	2.89684e-128
NC_017167.1\|WP_014463235.1\|351068_352277_-\|hypothetical-protein	gnl\|CDD\|367101	pfam02486, Rep_trans, Replication initiation factor. Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family, including myelin transcription factor 2 and cerebrin-50.	9.6487e-05
NC_017167.1\|WP_049784400.1\|366917_367220_+\|IS66-family-insertion-sequence-element-accessory-protein-TnpB	gnl\|CDD\|377551	pfam05717, TnpB_IS66, IS66 Orf2 like protein. This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.	6.48684e-48
NC_017167.1\|WP_014463234.1\|349614_350814_-\|DUF87-domain-containing-protein	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	5.38317e-20
NC_017167.1\|WP_158306708.1\|348066_349527_+\|glycosyltransferase	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	3.86342e-36
NC_017167.1\|WP_049784330.1\|366531_366864_+\|transposase	gnl\|CDD\|379154	pfam13384, HTH_23, Homeodomain-like domain.	0.00848548

>NC_017167.1|WP_148260097.1|356121_356718_+|hypothetical-protein
MKRTLSGIASAAIVLGAISPMAFGATSTSGLTPAGQLPIVVNGQVLSNPYEMVGIDSGNKTGFFPIYYFSQALAKIGIQATWNGVTHTWALTDSNVNAANVQVAGGIGTGNTTVTVNGTVVKKFNTQVARDPAAGPKGPITTYLPIYYINNILKALNINGSFSGQAGAQHPDPNGREHLHGGALADPGLRADGRHGCG
>NC_017167.1|WP_014463239.1|355184_355931_+|hypothetical-protein
MTLRPEDVFQHLADGKTRDEIAQMYGYKARRYLDQFMMRRGYQWSVERETYVERVTPKKKRRGQKVARVIEAFQAEPYGDPKRIAEALGFASAFEMAQYMQAHGYLWSNTARNYVAQDRTQDEVSPSTEADSPRQAVSNEGESASLPLGDALEILGMLVKHRAKLERLLLHTEQGATDVPRYTIPGLSVVKSLHISVELDRLLRSASQAWRMSQREILEAAVIEFLRKHGYDEVLHRLLTGRKQERTS
>NC_017167.1|WP_041694883.1|354312_355188_+|tyrosine-type-recombinase/integrase
MLGEEAITEFGAHLLRQGRSRKTVIGYQSDLRGFAAFYAKRHNLPWVVEETTVEDLRAYLDAQPAQAPTLNRRLYTFRSFFKYLVRQGVLTSNPAEMLEAKRVVQKERYALPADELARFIHHIPHPHVQAAAWTMAYTGLRMAEIIFLRMMDVDFEEGVVRVEHGKGDKPREVPISDALRPILSQYVEQYRKGAKPHERFFATPSTGGLSPTHINRVLKQTSQALGYRRYVTAHTFRHSFASNLIRQGVHITLVQKLLGHSSPTVTSVYTHATRDDLYRAVQTLSFEEGQA
>NC_017167.1|WP_014463237.1|353229_354081_+|helix-turn-helix-transcriptional-regulator
MARVPKQERVSDEQKKMFAQWLRQFREARGWSQTELARHLGVSLAYYNSLENANKTATRRKLYDIAQKLGDVRIIAQLFGKDVLERFQREHEARMVLATSHPDSPYEEVPIDPLLMWWGFSPRARVRLMRYSEWKREPFHGQLFYVTEGPLEEGSFYFANLQERTPQLESVASVLIRYFDLACDREMQLLDLDLSQMKKIPLYEGVRRLYVAIQVYESLDDAEEVHRRFTPLMTPRIRNLDVHAKRQVNLLAGYLSAVQAASPPPHAATGETSETLEPFVATP
>NC_017167.1|WP_158306709.1|352472_352694_-|hypothetical-protein
MSVSEAADHSRVFAEVGDPVLLTRFRFVLPVNTGIEAGDKVDLEVRNIRVSKTGSLMFEGQLHSRKPAEAPKA
>NC_017167.1|WP_014463235.1|351068_352277_-|hypothetical-protein
MWVEDHTTVFREFIQTLRRFRDEQAPDGQALPFYGPHLVYDAASTVGRWLAFRSWAKEAEGMRIRWRVYETEPPRKSNLWPIEVIFGSMELWAKPFRDWWQDVKQTLRWIADAPHKLYTFDGEWCVGSRVSRLDWAIDSDEWAFVPEDLPRFVTRSRMTDQHECEVEWLEYVQETPEVSHAVNRQFTGFSFGKSPVHVRIYDKHYELFASRKPAKAKFFLRLWEQNGWTGVPVWRVEIELRREVLHQMRYGARTFADMEADEVVAHFPVTIQYWFFQWMSLRQPTEDPNRSRWPLDAKWQRVIEAVSEDPDLFERVLPGPAFDVQSLARQQRTLLAKWALVRGLPPEACVTDAYLGQLAEALHLSPMQFLLSTEKEMHLLAGRHGARLPTLQDNKVWAKVVQ
>NC_017167.1|WP_014463234.1|349614_350814_-|DUF87-domain-containing-protein
MAIHVTHGPEHWRWVEWLLGAGAVLVAYVAWTGWIDRNRLIVDAFSFEEALRRADLWDNPRYKRPSLVRVKERANGDVELVVQGLPASIWQKPEIADPFCASFGVERFRSVTQDPKRRDRVHLVLASGSLDQVVKAAGREPGTRRLPKPKVKRDRDDEDAHPAARMSFLLGYGHDGRVFWQTPVWPHLLVAGSTGSGKSTLIRLIMQQALDRDWLVYLIDPKGGVDYLELLTWLAEPMKEFPQDALPLLETLWAKHRERLTKLKEAGVSSLREAHQQGLLLEEKPILLVVDELSIFSSNTGGKDEKEVRVRAHTYLERFALASRATGIALLLSAQYPTAEILGSQIRQQVWRICGRVDDEVASRTILGVPGAEKLPPDKPGRFLYVEHGELKEFQVTLP
>NC_017167.1|WP_158306708.1|348066_349527_+|glycosyltransferase
MVSDEVIRQKLLDGAFDEARKLALEQIKGVSWRAQSWVFLGEACLRLGNGKIARRCFERAWLLDPMAPWVNAVMKACDEVSAGKRDREVESALRVPKTTVSALVLFRDDARTIKRCIEALRPAVDEIIAVDTGSTDGSDVIASAFGAQVYRFEWTGDFAAARNFGLSKVTSQWVIAIDSDEILYAEDVDAIRTIAGVFESVRKESPVILRIVQMNLTGETVTPATSQSRMFPTGEDIEWRGLIHETPTLTKETARPAVRALVRIRVYHDGYDPKHVDLEKKFRRNLELLTEALEREPNNPVYEFYIGRESLFLKDYTKSIEYLERAEQHAKEIAGFSLLPDIRRRLAQAYMLAGKNEHMANKLEDMVKEHPEYPDGWFLRGEKKLREAGVLLQEAAQDFAKAQEAAQKYRGITEYDTAIGLWKAPAQLGEIARMRGNLVEARRWYQRVLKQEPNLKTIRERLEKLEQEACAIAQDVQEATKNTKDE
>NC_017167.1|WP_148260095.1|344936_347981_+|hypothetical-protein
MAKRNKSMRKMNLATAAAVASMLSAMTGGTAYAATVNSQAQSTGYYINGDFFNASDVLSNPSELAELNNLLAQNPTGLYLDLNGQIANYAGFIQYVQQNHLSASNSVFDAYAQANPFTIPSTATLVTPSGNAPYYEQTISAVNSSVGVFPSSITDGQAFTMTVTVNDANGDPVSGLSASSFVLNVNGKFVTASAAVYQGNGTYVLTFLPTTLTPGPDESEALVVDGTTVATSVGVDVSAGSVSTSGSTAVFPSNSVLDASGTYTVTVNLEDAIGNPISGATGTPTVSLGTGANAIPLTATALKAVTSTPGEYTFTFTAPTVSVSTALPLVVNVDGVTLTSTQTYTVTSDTPTALALESSLPATLEDGATYTVTVGAVDANGELVPTTSLATTTTSWTVEFAGNSATIKSVTTASTPGEYEVTFQMPSVTAGYVSKLTISDTTNNLSLTTSNSYTAGAGISSAASSVTWPSTTTLVEGQSYTVTVDVVDTSSNPVTGLTTSDFSITGPSTTIESVTPGSTSGSYVVTFELTTTTPGTLDVVVDGTTITSSPLTVTSVESTSVSAVTLSTLDGATASSVSAPVLLPGSSNTVTLDAGAVNLTSSDFSVELGNTPLSVTSVEPATTAGYYTLTFTAPNTTVSTPETLTFTVGTATTSINDVTVENNISATASTVVSGGPSTTTWTEGSTATFTVNVENASGDPVLGLPTSTFDITLGNSSNLVTSVTEDGGSYTVTVQAPNTVVTSATFSVSVDGVTITNGVPTSSYNVVASEPATFNSSVTFPSGNALHELIAGQTYTITATLDNAQGNPVLGLTTSDFALGYTTSSVTTTNGADTLPELPTSSFAVTGNSNGTYTITFVPTSASSSAEYLALLVDSQGVTTKGSSVSTSTSGAVFGDSTSLSVLPGAPEQLAVTAATATVSSTNSPDAVTVTLEDAYGNPITSDSSDVVTFSLATGSATGATLSATTATLSSGTASVTVTTPASSSDWGTGSSITVDASVTVNGHTYTGSVTIDE
>NC_017167.1|WP_014463230.1|344287_344710_+|hypothetical-protein
MSGGELNAYSAGGTTAIGAVPINWQGTETLQGSNGNSNSNGNSNNGGSNNQQSTLISNASASYALGLTNVKATVASGVTSVQIIDVTQNNNSLQTAQVSNGQVDTYVVGANAGDTLELVPYEGNTAESNAAVTVTVQQAE
>NC_017167.1|WP_158306710.1|358425_359559_+|hypothetical-protein
MQGYLYSNLQSATGTPFTITFGQGENTSVTAKLNTNYTVAVNSSNDPNSSININGGTATLNINVQVNNPDANPVGQGGASASANIQFQPGSGVSALGEATTIEGIENYGPLINTNSGTPNTISLQGIPWGNNQSQYFLQPSGEVTWLVAPFNNYVNLASIPNGGLNYTIASDGKNQDSINFIDGHEISNSKYNYSAQVVISKSGKTTVNGQVIFDPSAYGLQTVVAYTPDGNYILGQDSSGNYVLYDTQTGKQVADFGQVPMPADAQGDPMIVGGQVSTTSGGSGTLTLTWISGNGQSKATGTATNATETVSDELIPIQIVEVGAYGRFTGTYTYTATENGQTATAQVTYTSASTGSVQAVYATPQTLQARPTRRIL
>NC_017167.1|WP_041694885.1|359591_360404_+|hypothetical-protein
MPNATITITPQNLPGVWITAVNGVALQQSVPQGNTSQTEPTPVPLFNPADILPSGWQLDYNSISVPGALAATNIGSGQVPTITLTTNNNGEVQLTLEDGAVTYAAVNTTKGTGQNATYQLITAPSVQVSGGELNAYSAGGTTAIGEVPITWQGGAGNVATVTLGTFSTSSSTSPYDYSGTVTVTYPDGNPVTGLTYSNFAVSDNSGASGVNYTGVASNSTPSAGDFTVSGGTNGVYTLNVYTSSDVKGDTLTVKVTANGVSQTATATYSN
>NC_017167.1|WP_148260234.1|360463_361660_-|DUF87-domain-containing-protein
MGLHLAHGPERWQWLAWFLGVPAVFTVYLAWTGWLDRNRVIVDAFSFEEALRRANLWDNPRYRRPTLVRVKERANGDVELIVAGLPASIWQKPEITDPFCASFGVERFRSVSQDPKRRDRVHLVLASGSLDQVVKATSRELGARRLPKPKVKRDRDDEDAHPVARMSFLLGYGHDGKVFWRLPIWPHLLIAGSTGSGKSTLIRLIMTQALEGGWLVYLVDPKGGVDYLELLPRLAEPMKEFPQDALPLLEALWATHRERLTKLKEAGVSSLREAHERGFLLEQKPSLLVVDELSIFTSSTGGKDEKDMRTRAHAYLERFALASRATGIALLLSAQYPTAEILGSQIRQQVWRICGRVDDEIASRTILGISGAEKLPPDKPGRFLYVEHGELKEFQVMF
>NC_017167.1|WP_041695631.1|362119_363319_-|transposase
MYIRQTWLFSFDEWMEIDPSERRERFFSALDLSPYAAKLRSSTPQGAKPISREAILRAFLVAPLEGISSFTQLHRRLETDLRFRYQCGFSLHEPVPSVSTLSRVFQAIVNKGIAATLFADLVRQCRDEGLIEGEHVAIDSTAIHAYERKHPRSGVQPSNRANWGAKFDAFGNKLAWFGYKVHLAVDAKSELPMALTVTPANVYDGEMAIPLMEELHRQDWRIRFVLMDAGYDQTKNYEAARALGAQALIPLNRRNEREPPEGMDFDGTPRCTMGYRMTYWGAEGDWLKFRCPHATGHVDCPLGMAACSASNYGMVVKKHIDEDVRRYANPHRGSRTWKMLYDERTAVERCFSRLKEQLMLDDLHVRGIEKVTVHAYIHAIVLLASALAMHRTNRIEQVA
>NC_017167.1|WP_041694887.1|363616_365440_+|helix-turn-helix-domain-containing-protein
MSHLEQAESTEQQIDMMLKATSAIFQSDISIVYIRKDNQELFYPHACALTSNQQNILSQVPIAACCRRILSWPFRWPSDDREPALLHCAFFDNMDKMGFSTWFSLPLSISGFPLGIIAVGYYHFQYLVDDVGHILWEFAQDVAQALVPNLPEVLRQAVRHETPELPDAPYQQKMRRFLSNHYQLTSALWTDDGLHSIAHSVKQMLNRPTAVLDRFQSVLSICPEDARWHQLLHQVKHWMTLRSPFQETMWPLPVRTELEDQTTFVVAPIQTGDVIHGYLVIWENSAQLDDLDLIAVQEATMALAVHFYKRGFQIQRRGHGFQELFNFLLDQPEAWGAAESDAARAVGWDVEAEQRLLVGLPSAQSVLTHPAYLEHLSVLVDHLRSRLETEFPQILVARRHEAIVLSLPVSMPFEEIERLLNSIQTISLHMTGRLSNHLSARLFSELVEHMRFGISGPCTHPSQIVSAFEEASFACRLAPFITPTERILFTKDVQLYHLLRPIATSPKAKHFVSETADLLRAYDQQHGSELFKTLEVYLHHNCNLTDTSTALYIHRTTLQYRLKRIESLLNRSLDAAESKLEMQLAIIFRKIMDAEQVMNSVYDPFSD
>NC_017167.1|WP_049784330.1|366531_366864_+|transposase
MREHMSHQERRELWRERIAAFYDSGQSASQFCAEHGLKPHQFWYWLRRLRNETAPGTHDTTFVSVVTTSSPSDAGRSPLTLRIGSVEIDVRPGYDASTLAELIRLVMHVC
>NC_017167.1|WP_049784400.1|366917_367220_+|IS66-family-insertion-sequence-element-accessory-protein-TnpB
MRKSIDGLAALVQASFQLDPFSPCLFVFCNRQRDKLKILHWSHNGFWLYYRRLERGRFDWPETGDAKTMVITRRELNWLLDGLPLEQPKAHRAVHVRSAI
>NC_017167.1|WP_014463251.1|367269_368895_+|IS66-family-transposase
MTQENGTILMTEQEYEALQREKEQLRQQVAYLEEQIHLLRHRLFGASSEKRRKTPAESDSVQLPLFNEAEVEADAQPSEETGEADAEVTSEGVETETITYERRKPRAARERDAWLYQGEADEVVEYRLSDDERVCSKCAGELHEMSREITRRVKIIPAQMKKVEYVRYVYACRHCEAQDVETPVVRAPMPRPVQAKSLATPEAVAYVMTKKFVDGMPLYRQEQQFARHGYPLSRQTLANWVVHAAETWLEPLYAKLRQVLLAQRYLHADETTLQVLHEAGRAAQTQSYMWVYRSGMDGPPMVLYDYQETRSAEHPRRFLAGFQGYLHVDGYAGYEGLPDVTLVGCWAHARRKFDEALKAVPPKERKGKTAAEEGLSYCNALYAVEKKLKNASAEERQRVRMAKSKPILDAFLAWLEKQEQQMLPKSALGRAVNYGLKQWPKLIRYVEDGHLEIDNNRCERSLKPFVIGRKNWLFANTPRGARASAVTYSIVETAKENGLNPTAYLTYLFERMPNMDLKDEAAFEALLPWSEGLPDGIRVRN
>NC_017167.1|WP_014463254.1|370232_370889_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MKPAVKRSLQVGLGVVVAAALAGGGYYWYKSSQYLTTDDAYVDGFQYVIQAPASGKVVNWEGYVGATLTPGAVIGDIEAQSGNAMSDVPVESPGNVSIVQRDVADGEEVVAGTPMAYAYDLHNLYVTANVKETLIRQVHVGQKVKIDIDAYPGQTFEGVVARIGLSTASALSEIPSTSDNANFTKVTQVIPVTIDFTTYPVEPIVPGMDVTVHIVKNS
>NC_017167.1|WP_049784310.1|370904_372494_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MDAVSSTPTQHRSSPYLQLVIVLIGTFMAVLDTSVVNVAIPKMEVALNTNTSNIQWVLTGYMLVTGVIVPTSGWLIDTLGPKRLFLFALVVFTAGSALCGFAWNLPSIIFFRIIQGIGGGLLQPVAQTVIYRTFPPERIGSIMGVFGITIMGAPAFGPLISGYFVEYSSWRWIFFVNVPIGILALLLAIPYMDDLPTSPSFKLDVWGLTFSTIGFFSLLYGFNNVPDHGWGSTQVRVALAIGVVSLLLFVITELRAERPLLQLRLLTTYTYTMSLIVVSILSVALFVGIFLMPLYLENIRGYSALRTGLFVTPGALVSALVMPISGRLFDKIGARPLGLLGIGILAVSTYAFTFLTTDSTGAHIQLLYITRSLAMGIAMMPIMTAGTTAVVSKNPMLAGQAAALTNTIRNVASGLGTAVMTVYMTKRETIREAQLASQYDPGSPRALQLSQATAHYLAQGMSQTQAHAQAMLQITDNLQANAFVLGMNDTFMVSTLLAIAAWIVVLFIYPIGQSPQRRSSNPRVSPAMD

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Crispr_ID: NC_017167_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017167_4

2550334-2550419

Orphan

Consensus_repeat	Method
GCTGCAGCCGACTTCCAGGCGACTTCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017167_4

>merge|NC_017167|4|2550334-2550419|CRISPRCasFinder
GCTGCAGCCGACTTCCAGGCGACTTCCGGGATGCAGGGAGCACAACGGAACCTGGTAGCTGCAGGCGACTTCCAGGCGACTTCCGG

>NC_017167|4|4|2550334-2550419|CRISPRCasFinder
GCTGCAGCCGACTTCCAGGCGACTTCCGG	GATGCAGGGAGCACAACGGAACCTGGTA
GCTGCAGGCGACTTCCAGGCGACTTCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017167.1\|WP_014465426.1\|2557518_2558409_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381321
NC_017167.1\|WP_041695435.1\|2542628_2544233_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|171961
NC_017167.1\|WP_041695439.1\|2552414_2552822_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_017167.1\|WP_014465423.1\|2552837_2553614_-\|enoyl-[acyl-carrier-protein]-reductase-FabL	unknown	unknown	gnl\|CDD\|236145
NC_017167.1\|WP_014465409.1\|2539370_2539625_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|179197
NC_017167.1\|WP_041695440.1\|2555273_2557442_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372469
NC_017167.1\|WP_041695436.1\|2544248_2545409_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NC_017167.1\|WP_014465410.1\|2539660_2540440_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236145
NC_017167.1\|WP_041695437.1\|2546448_2547765_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215444
NC_017167.1\|WP_014465414.1\|2545405_2546437_+\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|181535
NC_017167.1\|WP_014465416.1\|2547929_2548268_-\|L,D-transpeptidase	unknown	unknown	gnl\|CDD\|341130
NC_017167.1\|WP_014465418.1\|2548723_2550199_+\|potassium/proton-antiporter	unknown	unknown	gnl\|CDD\|235410
NC_017167.1\|WP_041695438.1\|2551650_2552418_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NC_017167.1\|WP_014465427.1\|2558422_2559223_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NC_017167.1\|WP_014465420.1\|2551484_2551643_-\|activator-of-Hsp90-ATPase-1-family-protein	unknown	unknown	gnl\|CDD\|176856
NC_017167.1\|WP_014465424.1\|2553804_2555064_+\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	unknown	unknown	gnl\|CDD\|238430
NC_017167.1\|WP_014465429.1\|2560757_2561189_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NC_017167.1\|WP_014465411.1\|2540458_2542468_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239240
NC_017167.1\|WP_041695434.1\|2537658_2539317_-\|acyl--CoA-ligase	unknown	unknown	gnl\|CDD\|223395
NC_017167.1\|WP_041695441.1\|2559284_2560616_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910

Protein	Function_ID	Function_description	E-value
NC_017167.1\|WP_014465426.1\|2557518_2558409_-\|aldo/keto-reductase	gnl\|CDD\|381321	cd19095, AKR_PA4992-like, Pseudomona aeruginosa PA4992 and similar proteins. Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.	8.69102e-94
NC_017167.1\|WP_041695435.1\|2542628_2544233_+\|AMP-binding-protein	gnl\|CDD\|171961	PRK13295, PRK13295, cyclohexanecarboxylate-CoA ligase; Reviewed.	0
NC_017167.1\|WP_041695439.1\|2552414_2552822_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	3.97082e-29
NC_017167.1\|WP_014465423.1\|2552837_2553614_-\|enoyl-[acyl-carrier-protein]-reductase-FabL	gnl\|CDD\|236145	PRK08063, PRK08063, enoyl-[acyl-carrier-protein] reductase FabL.	5.47466e-142
NC_017167.1\|WP_014465409.1\|2539370_2539625_-\|acyl-carrier-protein	gnl\|CDD\|179197	PRK00982, acpP, acyl carrier protein; Provisional.	2.7928e-25
NC_017167.1\|WP_041695440.1\|2555273_2557442_-\|hypothetical-protein	gnl\|CDD\|372469	pfam13088, BNR_2, BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.	0.00909374
NC_017167.1\|WP_041695436.1\|2544248_2545409_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	9.19152e-97
NC_017167.1\|WP_014465410.1\|2539660_2540440_-\|SDR-family-oxidoreductase	gnl\|CDD\|236145	PRK08063, PRK08063, enoyl-[acyl-carrier-protein] reductase FabL.	8.84395e-86
NC_017167.1\|WP_041695437.1\|2546448_2547765_-\|hypothetical-protein	gnl\|CDD\|215444	PLN02830, PLN02830, UDP-sugar pyrophosphorylase.	0.000825171
NC_017167.1\|WP_014465414.1\|2545405_2546437_+\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|181535	PRK08673, PRK08673, 3-deoxy-7-phosphoheptulonate synthase; Reviewed.	1.02152e-175
NC_017167.1\|WP_014465416.1\|2547929_2548268_-\|L,D-transpeptidase	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.68798e-38
NC_017167.1\|WP_014465418.1\|2548723_2550199_+\|potassium/proton-antiporter	gnl\|CDD\|235410	PRK05326, PRK05326, potassium/proton antiporter.	1.79701e-156
NC_017167.1\|WP_041695438.1\|2551650_2552418_-\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	3.69628e-79
NC_017167.1\|WP_014465427.1\|2558422_2559223_-\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	7.20114e-15
NC_017167.1\|WP_014465420.1\|2551484_2551643_-\|activator-of-Hsp90-ATPase-1-family-protein	gnl\|CDD\|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	0.000290304
NC_017167.1\|WP_014465424.1\|2553804_2555064_+\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	gnl\|CDD\|238430	cd00834, KAS_I_II, Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.	0
NC_017167.1\|WP_014465429.1\|2560757_2561189_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	3.35235e-20
NC_017167.1\|WP_014465411.1\|2540458_2542468_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|239240	cd02930, DCR_FMN, 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the flavin and iron-sulfur cofactors. Metabolism of unsaturated fatty acids requires auxiliary enzymes in addition to those used in b-oxidation. After a given number of cycles through the b-oxidation pathway, those unsaturated fatty acyl-CoAs with double bonds at even-numbered carbon positions contain 2-trans, 4-cis double bonds that can not be modified by enoyl-CoA hydratase. DCR utilizes NADPH to remove the C4-C5 double bond. DCR can catalyze the reduction of both natural fatty acids with cis double bonds, as well as substrates containing trans double bonds. The reaction is initiated by hybrid transfer from NADPH to FAD, which in turn transfers electrons, one at a time, to FMN via the 4Fe-4S cluster. The fully reduced FMN provides a hydrid ion to the C5 atom of substrate, and Tyr and His are proposed to form a catalytic dyad that protonates the C4 atom of the substrate and completes the reaction.	9.23665e-165
NC_017167.1\|WP_041695434.1\|2537658_2539317_-\|acyl--CoA-ligase	gnl\|CDD\|223395	COG0318, CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	4.90302e-126
NC_017167.1\|WP_041695441.1\|2559284_2560616_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	3.49445e-43

>NC_017167.1|WP_014465418.1|2548723_2550199_+|potassium/proton-antiporter
METFLLILSLILLSGVWSAHLGNRLGFPVLIGFVTIGMLLGPGGLRLGPHVPISVAQSIGYLALILILFEGGLHTPLDRIRGVWKPALSLATAGVVISGAILTVMAHALLHLPWYAAALLGVAVSSTDAASVFSILGRHPLRRRLVDVLEVESGTNDPMAFFLTILLIQWSEHGIGRPWGALGYAISTFVLQMAMGLIAGAVIGYLGSLANQRIKLDTGGLYPTLSLAFALLSYSVAVLLHGSGFLAVYTAAVVMGNRRLEHRHSILRFHEGLSWTMHIVMFVVLGLQISPARLGSILVPGVLLAASALFLARPVAVWMSTIGMRFSAAEKVFISWAGLRGAVPIVLVMTAMLSPAYTPAPMLDAVFFVVIASTIVQGLTVRPLAAKLDLLERAPSGDLLELVRIARENAVITPVEVDASSDLVGRKMVEIEFPENTLCYAIVRGDQVIVPRGATELQAGDHLLILSDRRNIGRLRRLFGAERMGPAEMLP
>NC_017167.1|WP_014465416.1|2547929_2548268_-|L,D-transpeptidase
MAKYEIIVDLSDRRLYLLEAGKVIRAFPVGIGEMVTRTPIGQYTIVNKEPNPGGHFGAYWMGLSKPHYGIHGTNNPSSIGKLVSHGCIRMYNEDVTWLAHTVPLGTPVTIRP
>NC_017167.1|WP_041695437.1|2546448_2547765_-|hypothetical-protein
MRASRHVERITAAVLLGCLFTWMAAPKLEAQVIHRLPSVGAARASFVLPGRTLYRMASPPSGGDAFLAVAALRIGTASIPMDLWVTGSLDSGEVYVPLDILQKALDSIGFRSTWNATPFTWAIQTPTSRADTWGFPVGTGIGAVEVDGSLVTRLNVVPGVDLTSGWNGVDTAFLPLSQVSQLLADVGVQNTWDIASRVWTWIPPLQTSEPLGPSQGVEELRSDLLVSGANIVLRNLQVDGDVFVAPSPNGSVSLDHVSIDGKLVILASSGAPIQLTDIASPRIDVDSEGPVSIQLSGGAVGVLDVLPGVGGVQVASSKSSVLEVDDFATSAVVLAGSAYESAEIRADDGVLNAEASLPLVRVQASGATLTVGQGQTIGLLQVSPGVNGFSVDNFGTIQFLVNSSPHPVSTQGIGAVEAAMGAMTTLQASGTASGATGA
>NC_017167.1|WP_014465414.1|2545405_2546437_+|3-deoxy-7-phosphoheptulonate-synthase
MMVIRHGKVDLKQALEKAGLDAWVRALYPAGPGVSVLAAKEPGLAERVARVVGVTEVREVSRPYALASREYKPEDTVVEVRGHRIGAGGVTIMAGPCSVESLENIVDVAKAVKRLGGHVLRGGAFKPRSSPYSFQGHGEEGLKMMAAAREMTGLPIVSEVMEPGLVDLVAEYVDILQIGARNMQNYPLLREAGRSGKPVLLKRGLSATIEEWLMAAEYILAQGNPNVILCERGIRTYETATRNTLDLNAIPVVKSLSHLPVLVDPSHGVGKRAFVRPMARAGVAAGADGVIVEIHPVPDQAMSDAAQTIDYEEFGRMVQEVNRVALALAGSNEGASAREMVGV
>NC_017167.1|WP_041695436.1|2544248_2545409_+|acyl-CoA-dehydrogenase-family-protein
MMRTLYEWRKDVDAYVAGPARAWSEQIEATGTVPEALWRELRDAGYLRLAAPPHLGGHGLSFTDYLDLLRRFAHTHGSIRVIVHVANSLWRSLAQKATPDQVERFVKPFVAGDIRVTFTLTEPNSGSGADLKTTARREGDAYVLNGEKWMIIFSDVADYFLLFCRLEGTSGGDGTLALLVPRDAPGLTIEFMAPAMGIAGTAHGHLRLRDCRVPVANRLGEEGDGLEVAFRGFLDPSRTAIGMTCVGAAERALELAAQHALRRVTFGQPLAKRQIIQMWLAEMATDIEAARQLVLHTARRFDEGHPITVEAAMAKMFATEMLQRVTDKALQIHGGPGYFKSSEIERIYRDARMQRFEEGTSEIQKMVIARDVIDKAKRASEGSERR
>NC_017167.1|WP_041695435.1|2542628_2544233_+|AMP-binding-protein
MSAPLFLDQFETTLRDHPEQMAVIDLSGDEPVMLTYAKLERLAARIAARLLQLDVKPGEAVAYQLPSGWPFVALTLAIWKVGATPCPILPQLREREVAFILNSSESRVFIAPDAFRRFDYRPLVESVLKEAPRVEHTLILPMAPYAPLSSDLGGLLASEADAEAAKEALSARRPGPDSHSQLLYTSGTTGEPKGVLHTHRTLSEALLIHTRTLGLTSKDRIWVPSPTAHQTGFLYGMLVSFYIGAPGIYHAIWDVDKARAAIEEFGATFVQAAMPFLSDITRADRPPKGLRLFIATGAAIPRQLAQEAREKLQCAVVGAWGSTESCLVTVGRPSDPPEKLWGTDGRVLDGMQIRVVDEEGRELPPGTEGNFQVKTPAMFVTYLHHPEWYEAAMTPDGFFDTGDLAVIDEDGYLRITGRKKDVVNRGGEKIPVVEIEDLLYQHPDIADAAVVAMPDERLGERACAYVVLKPGAKRLELCDITDFLGERGMAKIYWPERLEIIDEMPRTASGKIQKYVLRQDIQRKLERERAEKTG
>NC_017167.1|WP_014465411.1|2540458_2542468_-|FAD-dependent-oxidoreductase
MPERWMKRRYEALAQPGKIGSLELPHRILMGSMHMGLEHDDDEMMARLCAFYRERALGGAALIITGGACVLPEGGGHMFVLTNPRHVERLAQLPKAVHEVGGRIALQLYHAGRYAFSEEIGQQAVAPSPLPSRLTRETPREMTLEDIRRTIEGYANAARTAKEIGFDAIEIMGSEGYLLNQFLSPLTNHRNDEYGGDFERRMRLPLEVVEAVRRAVGPAYPIIFRMSGLDCMPGSTTPEETLQFAQALERAGVDALNVGIGWHEAAVPTVQQVVPRGGFAGVAAFVRQHVTVPVLAANRLNVPEVANELVADGFLDFIAPARPWLADAEFAKKILEGDRDGLNVCIACNQSCLDHTLVKPYRVVSCLVNPRAGYEALRPRVKAQVKRRVAVVGGGPAGLEAARAAAERGHEVTLFERDKELGGQFRLASRIPGKDEFLETIRYYEVMLERLGVTVTMQTEPSLDQLAEFDDVIVAVGVKPKAPGIPGEDLPHVVSYQDLLMGRVQPGQNIVILGAGGIGCDVAVFLGTRRRMTPEALAFFEEQGLPVPEPIERTITMLARSDRIGRGIGRSTRWVVRQEMERLGVNVVPNVAMLEITQDGVRIAREGHEEVVPADQVVLCTGQLSQDTSWAEKLPPRVRVHVVGGARDSRDINAARAIREAWTAAYEIG
>NC_017167.1|WP_014465410.1|2539660_2540440_-|SDR-family-oxidoreductase
MLLEGKRAFITGSSRGIGRAIAIQMAKHGADVVVHYRRQPEEAEATAQAIRDLGRRAMVVKAELEIQDELNQAFDQIEREFGDLDIFVANAAASAFKPIEQLKDYHLDRTYRVVIHSTVFAAQRVIPMMERRGGGRIITMSSMGSTFTLPNYATLGTAKAALEALTRYLARETAPKNITVNAINPGVVDTESARFYGADHYDAYRRDVEAHTPLGRLASPEEVADVAVFLASDLSRFVTGQVIWVDGGLTLLTGGFESF
>NC_017167.1|WP_014465409.1|2539370_2539625_-|acyl-carrier-protein
MATLSREEIEARVRKVVANQLQVSESEVKPDSLFVDDLGADSLDLTELAVAFEDEFDLEIPEADFGQLSTVAGVVDYIERRLSA
>NC_017167.1|WP_041695434.1|2537658_2539317_-|acyl--CoA-ligase
MFDFPGRTLTEERAKLYFEKGYWTNESFVDVLFEDVKKYPNFVHRDETREATYEKLWSEVESVAAHLYRMGVRKGDTVALQLPNVLDYVVAVFACARIGAIGVSLQIDLGRQAIISSMRTSRAKVWIIADYFRGESLFEMAVSLKPELPDLTHIVVQGDPERAPEGATTFASLREAGDKLGEAELEANKPGPLDAFLMVFTSGTTGSPKGVVHLHANYLWAARAYAKNFGYQPGEAVLCLAPICHQTGMLAGVMMTVASGGRIMLLDRFSAARVIDWIEKYKPTYLVGAPPHVIHVANAPNLKQADTSSVKLFIYAGAPVPKAVLEQLQRDSGIKVGCMFGWSEGFLATATRPDDPLEALSSTVGFVIPGTEVRLVDEEGHDVKPGEPGEMWARGPNFSAGYYHNPEAAHRQWDEEGWFHSGDILRQDENGRYIFIARADDIINRGGTKIDPKTVEDAISKHEAVQNVAVVGAPDPTLGQMTVACVILKEGAKPFTLRELRDFLAEQGLAKFQFPDRLEFMTEFPQTHSGKIKKKDLRERFRLEAEGQGAHA
>NC_017167.1|WP_014465420.1|2551484_2551643_-|activator-of-Hsp90-ATPase-1-family-protein
MAQLPDIVVDVVIDASAEKIWPYVATADGLGAWFMGSTPSFARSWRAAGGAS
>NC_017167.1|WP_041695438.1|2551650_2552418_-|SDR-family-oxidoreductase
MRDMEGRVAIVTGGAGGIGSATARRLAERGVRVVVADRDEAGARRVADEIRAAGGEAEGMFVDVTDEASVNALVDAAVARFSRLDIMFNNAGVFGDGARNFLDDPPEEYFRVVSINQHGVFYGMRAAARHMRQAGTGGVIINTASIYAFIADRNQLPYHASKAAVVAMTKAAALDLARYNIRVVAVAPGMVNTGLVDNWRQDERVWNTIQRAHMRRRMAEPDEIARVVAFLASDEARFINGHAICVDDGALSFKR
>NC_017167.1|WP_041695439.1|2552414_2552822_-|acyl-CoA-thioesterase
MEGFRYHYDLEVRWSEVDAQRIVFNANYLMYLDLAYQEFFRSELRLYDDVPTTVIATSTQTFLKPARWRDKLSIWVRPKRIGNTSVTLEFVMTREGEPIFRAETVYVHVDENGRPEPIPAFWRERLRAYQEEALA
>NC_017167.1|WP_014465423.1|2552837_2553614_-|enoyl-[acyl-carrier-protein]-reductase-FabL
MANAGRAPRRFEDKVVLVTGSSRGIGRRLAIRFAEEGAHVVVNYFRNGDLAREVVAEIEQMGRRAIAVRANMAQEEKIVALFDEVREVFGRLDVFIHNAASGRNRAALEVDTKGFDWTVDVNARAFLIGAQQAAKLMPEGGAMLAISSFGADRVFPYYLSVGTSKAALEAMVRYFAVELGPRRINVNCISAGAVLTDALGHFPDMDQTLKKLEEKMPYHRMVTPDDVANLALFLCSPEAEMIRGQTVRVDGGVTLVLP
>NC_017167.1|WP_014465424.1|2553804_2555064_+|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein
MADKTRIVVTGMGAVTPFGVGVSTFWENIVAGRSAVRETEDELLRTWAPVVAAARDFDPAAYLDKKQMQNSDRFTQMGLVAAAEAIRDAGFGDGGAFGPYERDRIGISIGCAFGGVQTLEEGSNRLASGRSTRVGPRLVPKSIPNAAAAGIAMRYGIRGPVMTYSTACASSANAIGEASYWLRLGEIDMALVGGAECLFSPAILAGLRAAGALATEGPADYSAWSRPFDKRRTGMVMGEGAAVLVLETLERALERGATIYGELVGYGTSNDAYHETSPDPSGHGAKLAMARALKSAGLAPEDIDYVNAHATATPAGDVAESTALRDMFGPHIDEIPVSSIKGAVGHMLGTAGAIESIACVKALETGWLPPTLNCDDKEEIAPRDVVPNRSRRADIRTALSSSFGFGGQNGVLIWKKAEI
>NC_017167.1|WP_041695440.1|2555273_2557442_-|hypothetical-protein
MRRWMWLGAVCVVCGMLAVGCGAQGVSGEKAPGSLPGSSAAGANANGTPAKGAEVTADTNRSSTERALASRGSFEILGHPGWGPARVTQVVPPSFAGATAFAALVGQSSSAIIKSVAGKPWHVVSEIPGQVAAISFSSPSDGAVITVARKTVSPTMAEGPATYRIWLTRDAGASWRSVWQITVSTGHEMSAEMPVLALFGATGYAAVSGELLRSADGGATWARVPLQDAVLDAAFLSPTRVWLSEVSPQVFRAGNHPAPVVMAESEDGGRTFHTVLTGPSVVPWQENLAMTASGVGVWVVKDLGSWETRVLWTTNGWASWREAMPQAYQGRVAQSVPVLDGDVAYIGLCPGAAPFPGGVTSFDLRTGQASTLATVPYWYSVSLARSPSGAWYAAPSSSEPTGLYASGPGLDTWHRVAPTAPPDVQVVADPALGSDGRPALVGIDGDLFQGTVEESVDGGASWRVLTRMPHQMPIAVAAGPGKLLAVATVGASDDNGPLRLWVSRDGGQHWTELGAADLPSNVVQSLTPFGPSDAALSVTADGYVLAIAAMPKDLVLQSRDGVHWSTVRSVPNDDLALAPAFDGGTVWWLDNKLIRPGSKSNGKDTGPVLQPVLTASPVSGNAERTVSLPEGYDALAMAWAGSRGMVVCASSATMDPSQGLTLFVTTDGGATWSTRHLAPGFQSKLPGEVMSLTLAGGDFGALLTDAGLLVTRDGGWTWAYAP
>NC_017167.1|WP_014465426.1|2557518_2558409_-|aldo/keto-reductase
MEYREFGRTGMRVSALGFGGSEIRGSDVATVERLLASALDAGLNVIDTGECYGDSEELIGRAVGHRRGEYFLFTKCGHRSGLETPDWAPETIRASIDRSLKRLRTDYVDLMQLHSCSIEVLKEGSVIEELQKAKEAGKIRFLGYSGDNEAAKYAVEFGVFDSLQTSVNVVDQSAIEEVIPLAAARGMGVIAKRPVANVAWRYHEKPDVDYYVEYWRRLRELKFPFTERPLSEAVGVALRFTLSVPGVTTAIVGTQNPGRWQENARYVDEGPLPKEEFDAIREAWRRVARPDWVGQT
>NC_017167.1|WP_014465427.1|2558422_2559223_-|HAD-family-hydrolase
MHQDPYVRIGRAKLFIFDLDGTVYAETEHFEAYARELASFLPESRREAFLEDAHRALLHEGQAFYGHAFSRETGERVEVAEEDRPDRAYLHVDDPWGLLQVVAIRHGIGPRERDEAFLRTRDFMAGPFPMQPLGGLREAMEEIRARGGHVVLATNSPEPDSRAILRKLNLEDVIEDFVFRAVKPYRTEEHFRKWLAKYGVAPERAVSIGDHYRNEMRPAIRLGMLTIYIDRYIGRERPDVTLRLTHPGELGDVLVTCLRRAEEAEA
>NC_017167.1|WP_041695441.1|2559284_2560616_-|methyl-accepting-chemotaxis-protein
MEKTSEALRSGTGIGSANERAVRVSLRVKMIVVVIVSLVVSIPLSDAINAAIRRAVPDSHYGIYVNSAVSVIVSAALLLVAIQILVIRPLGRLVRAVQDVAAGNLAARVAVETQDEMGLLARELNAATAAMQEVIRELARTSGDLAAASQELAASAEETGKAAEQIALTIQDVSAGVQRQDARIASSTDVFQLLARGMEDMSARFRGASEATAQAREAARDGGEHVAQALAQMASVEGAFEHLAQAVRSFASRSQEVGAIVEVITRIAKQTHLLALNAAIEAARAGEAGRGFSVVASEIRKLAEQSADSSKQIASLVDAIQADMENAAERMASSREQMEAGKASFEAVDASFARIRQAVERVDEELKGVLTFVNRLGRASAQLREGVDEIAQVSAQTSAGMETVAATTEEQLASMQEMTASAAALAQMAESLQRMVASFRLEA
>NC_017167.1|WP_014465429.1|2560757_2561189_+|PaaI-family-thioesterase
MGFDYCFACGKDNPHGLHMHFERDGDGVVCHFQTQEHHIGWPNVQHGGITCTLLDEASAYVPFFMGLVTVTAELNISFKKPVHVGERLRVWARPTKVSSRLLVVEAAVEGEDGELKASSTAKMMVLSAEKQKQLGMEGLEAKR

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Crispr_ID: NC_017167_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017167_5

2812009-2812628

Unclear

Consensus_repeat	Method
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	PILER-CR
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CRISPRCasFinder
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CRT

8 spacers

c2c9_V-U4,cas4,cas1,cas2,cas3,cas8u1,cas7,csb2gr5

The CRISPR arrays of NC_017167_5

>merge|NC_017167|5|2812009-2812628|PILER-CR,CRISPRCasFinder,CRT
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCGATAGCCCGGATGAGGCCCTGATGTGGCCCGCCAAGTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCACTTCCGCAAACCGCGTCTGCTCATAGCTCGTGTCGTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCCCACAAGCAAATAAATCTTGCAATTTCATTTCGAGAGTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCTGGATCATGCCCCAGGAAGTCCCGCAGACAATTCCGTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCACCCACTTTGATGTGATGTCGTCACAACTGACTGTGCGTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCACATGTTTGTGTAGACAGAATACTGGTCGGTATTGATGTTGTTCCGCCGAGATCGTCGGCGCCCCCATTGAAGCGCAATCTGGGCGGTGTGAAAGTACCGCGTCCTGGGTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGCGAATTCGAGCGGTGGAACAACGGCCCAGCGAATTACTTGTTCCGCCGAGATCGTCGGCGGCCCCCTGAAGCT

>NC_017167|5|2|2812009-2812556|PILER-CR
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GATAGCCCGGATGAGGCCCTGATGTGGCCCGCCAA
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CACTTCCGCAAACCGCGTCTGCTCATAGCTCGTGTC
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CCCACAAGCAAATAAATCTTGCAATTTCATTTCGAGA
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TGGATCATGCCCCAGGAAGTCCCGCAGACAATTCC
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACCCACTTTGATGTGATGTCGTCACAACTGACTGTGC
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CACATGTTTGTGTAGACAGAATACTGGTCGGTATTGAT
GTTGTTCCGCCGAGATCGTCGGCGCCCCCATTGAAGC	GCAATCTGGGCGGTGTGAAAGTACCGCGTCCTGG
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC

>NC_017167|5|5|2812009-2812628|CRISPRCasFinder
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GATAGCCCGGATGAGGCCCTGATGTGGCCCGCCAA
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CACTTCCGCAAACCGCGTCTGCTCATAGCTCGTGTC
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CCCACAAGCAAATAAATCTTGCAATTTCATTTCGAGA
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TGGATCATGCCCCAGGAAGTCCCGCAGACAATTCC
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACCCACTTTGATGTGATGTCGTCACAACTGACTGTGC
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CACATGTTTGTGTAGACAGAATACTGGTCGGTATTGAT
GTTGTTCCGCCGAGATCGTCGGCGCCCCCATTGAAGC	GCAATCTGGGCGGTGTGAAAGTACCGCGTCCTGG
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GAATTCGAGCGGTGGAACAACGGCCCAGCGAATTA
CTTGTTCCGCCGAGATCGTCGGCGGCCCCCTGAAGCT

>NC_017167|5|2|2812009-2812628|CRT
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GATAGCCCGGATGAGGCCCTGATGTGGCCCGCCAA
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CACTTCCGCAAACCGCGTCTGCTCATAGCTCGTGTC
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CCCACAAGCAAATAAATCTTGCAATTTCATTTCGAGA
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TGGATCATGCCCCAGGAAGTCCCGCAGACAATTCC
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	ACCCACTTTGATGTGATGTCGTCACAACTGACTGTGC
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CACATGTTTGTGTAGACAGAATACTGGTCGGTATTGAT
GTTGTTCCGCCGAGATCGTCGGCGCCCCCATTGAAGC	GCAATCTGGGCGGTGTGAAAGTACCGCGTCCTGG
GTTGTTCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GAATTCGAGCGGTGGAACAACGGCCCAGCGAATTA
CTTGTTCCGCCGAGATCGTCGGCGGCCCCCTGAAGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017167.1\|WP_014465674.1\|2818412_2818616_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219
NC_017167.1\|WP_041695505.1\|2821139_2821394_+\|DUF2273-domain-containing-protein	unknown	unknown	gnl\|CDD\|378362
NC_017167.1\|WP_193352809.1\|2798397_2799183_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_017167.1\|WP_041695946.1\|2820595_2821147_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	unknown	unknown	gnl\|CDD\|380217
NC_017167.1\|WP_014465668.1\|2810353_2811505_+\|transposase	c2c9_V-U4	-	gnl\|CDD\|223747
NC_017167.1\|WP_041695500.1\|2804227_2806858_-\|CRISPR-associated-helicase-Cas3'	cas3	cd09696_cas3_CAS-I-U	gnl\|CDD\|274235
NC_017167.1\|WP_193352837.1\|2818656_2818917_-\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197385
NC_017167.1\|WP_014465661.1\|2801957_2804231_-\|type-I-U-CRISPR-associated-protein-Csx17	cas8u1	cd09767_cas8u1_CAS-I-U	gnl\|CDD\|274989
NC_017167.1\|WP_014465667.1\|2809794_2810382_+\|IS607-family-transposase	unknown	unknown	gnl\|CDD\|225296
NC_017167.1\|WP_014465671.1\|2814765_2816238_-\|cytosine-permease	unknown	unknown	gnl\|CDD\|224374
NC_017167.1\|WP_014465664.1\|2807866_2808907_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NC_017167.1\|WP_014465673.1\|2817450_2818263_-\|Dam-family-site-specific-DNA-(adenine-N6)-methyltransferase	unknown	unknown	gnl\|CDD\|182825
NC_017167.1\|WP_041695502.1\|2812637_2814359_-\|phosphomethylpyrimidine-synthase-ThiC	unknown	unknown	gnl\|CDD\|236451
NC_017167.1\|WP_014465660.1\|2800978_2801941_-\|type-I-U-CRISPR-associated-protein-Cas7	cas7	cd09678_cas7_CAS-I-U	gnl\|CDD\|378223
NC_017167.1\|WP_014465665.1\|2808894_2809530_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NC_017167.1\|WP_014465663.1\|2807562_2807853_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_017167.1\|WP_014465681.1\|2821464_2821839_-\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|377129
NC_017167.1\|WP_014465682.1\|2822028_2822523_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_017167.1\|WP_041695503.1\|2816581_2817373_-\|membrane-protein	unknown	unknown	gnl\|CDD\|227049
NC_017167.1\|WP_041695499.1\|2799365_2800982_-\|type-I-U-CRISPR-associated-protein-Cas5/Cas6	csb2gr5	cls000315_csb2gr5_CAS-I-U	gnl\|CDD\|274005

Protein	Function_ID	Function_description	E-value
NC_017167.1\|WP_014465674.1\|2818412_2818616_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	1.7279e-17
NC_017167.1\|WP_041695505.1\|2821139_2821394_+\|DUF2273-domain-containing-protein	gnl\|CDD\|378362	pfam10031, DUF2273, Small integral membrane protein (DUF2273). Members of this family of hypothetical bacterial proteins have no known function.	0.000575837
NC_017167.1\|WP_193352809.1\|2798397_2799183_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	3.42605e-30
NC_017167.1\|WP_041695946.1\|2820595_2821147_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	gnl\|CDD\|380217	NF033218, anchor_AmaP, alkaline shock response membrane anchor protein AmaP. The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.	5.92445e-15
NC_017167.1\|WP_014465668.1\|2810353_2811505_+\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.11859e-67
NC_017167.1\|WP_041695500.1\|2804227_2806858_-\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|274235	TIGR02621, CRISPR-associated_helicase_Cas3, CRISPR-associated helicase Cas3, subtype Dpsyc. This model describes a CRISPR-associated putative DEAH-box helicase, or Cas3, of a subtype found in Actinomyces naeslundii MG1, Geobacter sulfurreducens PCA, Gemmata obscuriglobus UQM 2246, and Desulfotalea psychrophila. This protein includes both DEAH and HD motifs.	8.30076e-43
NC_017167.1\|WP_193352837.1\|2818656_2818917_-\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|197385	cd10148, CsoR-like_DUF156, Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156. This superfamily includes various transcriptional regulators that respond to stressors including Cu(I), Ni(I), sulfite, and formaldehyde. It includes CsoR (copper-sensitive operon repressor) from Mycobacterium tuberculosis (MtCsoR), Bacillus subtilis (BsCsoR), Thermus thermophilus (TthCsoR), and Staphylococcus aureus (SaCsoR), Mycobacterium tuberculosis RicR (regulated in copper repressor, MtRicR), Escherichia coli RncR (formally known as YohL, nickel and cobalt-sensitive), Alcaligenes xylosoxidans NreA (nickel-sensitive), E. coli FrmR (formally known as YaiN, formaldehyde sensitive), and Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor, NWMN_0026.5, SaCstR). CsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis. For example, TthCsoR binds the promoter region of the copZ-csoR-copA operon, and represses expression of these genes, which encode the copper chaperone CopZ, CsoR, and the copper efflux P-type ATPase CopA, respectively. In the presence of excess Cu(I), TthCsoR binds this ion, and is released from the DNA, allowing expression of the downstream genes. TthCsoR also senses other metal ions such as Cu(II), Zn(II), Ag(I), Cd(II) and Ni(II). CsoRs form a homotetramer (dimer of dimers). In the case of MtCsoR, two Cys residues on opposite subunits within each dimer, along with a His residue, bind the Cu(I) ion. These residues are conserved in the majority of members of this superfamily. Exceptions include the functionally uncharacterized Bacillus subtilis YrkD where there is an Asn instead of His (C-N-C), E.coli RcnR where there is a Thr instead of the second Cys (C-H-T), or TthCsoR and E.coli FrmR where there is a His instead of the second Cys and which have an additional N-terminal His (not found in those family members having C-H-C) that may also be involved in metal binding (H-C-H-H). A conserved Tyr and a Glu residue facilitate allosteric regulation of DNA binding. SaCstR regulates genes predicted to function in sulfur metabolism; it is thought that oxidation of the intersubunit Cys pair to a mixture of disulphide and trisulphide linkages by sulfite, results in a reduced affinity of SaCstR for the operator DNA. SaCstR exists as a mixture of oligomeric states, including dimers, tetramers and octamers. The sequence of SaCstR was not available at the time this hierarchy was curated and therefore was not included. Escherichia coli RncR represses expression of the gene encoding the nickel and cobalt-efflux protein RcnA. The gene encoding Alcaligenes xylosoxidans NreA is part of the nre nickel resistance locus located on the pTOM9 plasmid from thisbacteria. Escherichia coli FrmR regulates the formaldehyde degradation frmRAB operon.	6.65987e-33
NC_017167.1\|WP_014465661.1\|2801957_2804231_-\|type-I-U-CRISPR-associated-protein-Csx17	gnl\|CDD\|274989	TIGR04113, hypothetical_protein_AaLAA1DRAFT_1703, CRISPR-associated protein Csx17, subtype Dpsyc. Members of this protein family are found exclusively in CRISPR-associated (cas) type I system gene clusters of the Dpsyc subtype. Markers for that type include a variant form of cas3 (model TIGR02621) and the GSU0054-like protein family (model TIGR02165). This family occurs in less than half of known Dpsyc clusters.	0
NC_017167.1\|WP_014465667.1\|2809794_2810382_+\|IS607-family-transposase	gnl\|CDD\|225296	COG2452, COG2452, Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair].	4.18665e-58
NC_017167.1\|WP_014465671.1\|2814765_2816238_-\|cytosine-permease	gnl\|CDD\|224374	COG1457, CodB, Purine-cytosine permease and related proteins [Nucleotide transport and metabolism].	3.80915e-41
NC_017167.1\|WP_014465664.1\|2807866_2808907_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	5.68442e-149
NC_017167.1\|WP_014465673.1\|2817450_2818263_-\|Dam-family-site-specific-DNA-(adenine-N6)-methyltransferase	gnl\|CDD\|182825	PRK10904, PRK10904, adenine-specific DNA-methyltransferase.	1.53993e-126
NC_017167.1\|WP_041695502.1\|2812637_2814359_-\|phosphomethylpyrimidine-synthase-ThiC	gnl\|CDD\|236451	PRK09284, PRK09284, thiamine biosynthesis protein ThiC; Provisional.	0
NC_017167.1\|WP_014465660.1\|2800978_2801941_-\|type-I-U-CRISPR-associated-protein-Cas7	gnl\|CDD\|378223	pfam09617, Cas_GSU0053, CRISPR-associated protein GSU0053 (Cas_GSU0053). This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).	2.88718e-53
NC_017167.1\|WP_014465665.1\|2808894_2809530_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	5.49624e-35
NC_017167.1\|WP_014465663.1\|2807562_2807853_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	4.18156e-27
NC_017167.1\|WP_014465681.1\|2821464_2821839_-\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	4.47272e-32
NC_017167.1\|WP_014465682.1\|2822028_2822523_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	5.79557e-27
NC_017167.1\|WP_041695503.1\|2816581_2817373_-\|membrane-protein	gnl\|CDD\|227049	COG4705, COG4705, Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown].	2.03854e-58
NC_017167.1\|WP_041695499.1\|2799365_2800982_-\|type-I-U-CRISPR-associated-protein-Cas5/Cas6	gnl\|CDD\|274005	TIGR02165, CRISPR-associated_protein_GSU0054_family, CRISPR-associated protein GSU0054/csb2, Dpsyc system. This model represents a CRISPR-associated protein from the Dpsyc subtype (a type I-C variant), named for Desulfotalea psychrophila LSv54. CRISPR systems confer resistance in prokaryotes to invasive DNA or RNA, including phage and plasmids. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associated proteins, have low levels of sequence identify, have sequence relationships that suggest lateral transfer, and show some sequence similarity to DNA-active proteins such as helicases and repair proteins.	5.20641e-47

>NC_017167.1|WP_014465668.1|2810353_2811505_+|transposase
MKIHRAYRYELAPNRMQRSLLAKHAGAARFAYNWGLARRIALYEETGQSTNAIEQHRELNRLKKTDFPWMYEVSKCAPQEALRDLDRAFQHFFRGLKEGRRVGFPRFKKKGRDDSFRLTGSIRVLDNAIQLPRLGRIRLKEKPHVEGRILSATVKREADRWYVSLSAETEIPDPVPPSGEPVDVDLGVSWFLTLSDGTKIEAPKPLARYLRRLRRLSKRHSRKKPGSRNRRKSALALARLHRKIRNIRQDFLHKVTTELAKTKRVIVIEDLHVRGMVQNRALARAISDVGFGEFRRMLTYKCTWYGSELIVAPRFYASSKTCSACGYVISELPLSVREWTCPACSTRHDRDINAAKNLLRIGTASSAGSDACGDPSGGAALGC
>NC_017167.1|WP_014465667.1|2809794_2810382_+|IS607-family-transposase
MKLSDWARKNGITYKTAWRWVKEGRMPVPFEQTPSGTILVREPESSTANAVALYARVSSADQKDDLDRQIARLMEFATEQKLVVFKAVTEIGSGLNGHRPKLMKLLSNPDAHTIVVEHRDRLMRFGFEYVEAALAAQGRRILVVEPGEVKDDLVQDMIEVLTSFCARLYGRRSARHRAKRALEVFKREDSSGVSV
>NC_017167.1|WP_014465665.1|2808894_2809530_-|CRISPR-associated-protein-Cas4
MDDDWLIPVSALQHYAYCPRQCALIHVEQTFLENELTTNGHFLHQRVDEDHVFSSRGHKVITGMRVWSERLGLIGRCDAVELHGETPYPIEFKHGKARRSRSQQVQLCAQALCLEEMFDTPVPEGAIFHIHSHRRSRVIVDDALRALTLGVIARVREMFLRNEVPPPVADRRCLRCSLQPVCLPHWSKLRSDASFWRAIEQDLGGETSCRL
>NC_017167.1|WP_014465664.1|2807866_2808907_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MPPVMLKTLFVQRDGAVVRIHQDTVLVTLEGETLLRVPLHMIESIVGIGRVSFTSPLLERCAADGRSVVRMTRGGRFLYRIEGRLSGNVLLRAAQYEAARSPEKSLAIMRAIVAGKVHNQRQLLLKASRDLADPADRAAARAAADDLARELRKLPSASHPDEVRGIEGVTARRYFAALRHLLVSSVREVLTFDGRNRRPPRDPVNAVLSFLYTMLTRDAESALLGVGLDPQIGFLHTLRPGRPSLALDLIEEMRPILADRVMLSLFNRRQLQPSDFEVLPGGAIELGEAGRRAVFAEWDRRKQAEIEHPLLKQPVTYGRLLDVQARMLARAIRSQGPGYTPFLYRG
>NC_017167.1|WP_014465663.1|2807562_2807853_-|CRISPR-associated-endonuclease-Cas2
MYYIVTYDVATDTREGQRRLRRVAQACEGYGQRVQKSVFECVLDELRYVELVHRLGAIIRRDEDSVRIYRTQDFTKSSLLVLGRNLGLDLNGPWTV
>NC_017167.1|WP_041695500.1|2804227_2806858_-|CRISPR-associated-helicase-Cas3'
MDFSEFFIRATGSPPYPWQSRIATASTWPDLLRIPTGAGKTGVILAWLWRRLHGGDEMEQRTGRRLVYVLPQRSLVAQTAETARAWLAALGLEGDVGLSVLMGGSIDHAWDLEPDKSWIIVGTQDQILSRALNRGYGGVSRFRWPLQFALLHNDVQWVVDEVQLFGDGLATTAQLQAFRERFGTHGPAHTLWMSATASPEWLQTVDLREAGRELEVWELDDADREALRARLVARKPLERCPVILDDEASKKPEAYAKKLAEWLLGRRPADGLTLVILNRVDRAQVVYQALKRAAPEEDVRLAHGQFRARDRAWLAEQARSLGDTRAILVATQVVEAGMDLDATALVTELAPWSSLIQRFGRLNRTGTREAARAFWIDIARDSKVAYEPYHPADLDRARAQLERLEDVGPSRLPGEIDPLTYQRVLRRRDLLQLFDTTPDLGGNDIDVSPFIREIEDRTVSVYWGEWTGDAPPDALRAVADEDVCRVPMSRLQEYLKKKRKVRGAEQTRVAYIWNSLIGRFEEVKEQRVFPGRLYLLRAEDGGYSPDLGFDPDLWSTVPNPVEARGPGEVDAEDGEEDNGPSPGRPVTLEEHTLDVMREAEALRPLAGSDEIAEVLREAAFWHDSGKRHPLFQAKLRLAALGEEAYREKYGSQGPGQSPVYPPDEIPMLAKSGGRAGLRSYPQVCLREDRQSSAEAAAGQEGDHGGVWGGAEGQGEDRAAANAGNKAQAGQIRSIRGFRHELASGLAYLEQVPPEEANHLRTRLVAYLIAAHHGKIRGQIRASARERAPEDGRLFARGVWEGDQLPAYAVSSEGSWPEALLSLSVMRMGRDEAGRESWVHGVQRLLEAYGPFRLAWYEALLRVADSRASRREGGVEA
>NC_017167.1|WP_014465661.1|2801957_2804231_-|type-I-U-CRISPR-associated-protein-Csx17
MKREIRLFGCRPVPIAGYLKAIAVMRLVAEQKDPDLRSYWQHDVFCLQTELSEADLVEFFLREYRPTPIMAPWNGGGGFIGGKNAEPVDWLRKSTGARFEPYRAALRVVDRLFADAPLSDKPKDEDKVELLARLRAELPDEAVEWLDAVAAITTDRLGLAPLYGTGGNDGNFEFTNNFMQRLSELFQPDGSPAPSTERLLRAALFEEPVNGLFNVSIGQFQPSQNGGPNAGPGFEAGRRVNPWDFIFAMEGGELFSAAASRRLGSQHVDFSYPFTVRATAGGQGAMSTADEGQRARAEMWLPLWKQPVSLEELEQFFQEGRAQVGWRPARTGLDFARACANLGIDRGIDSFQRYAFLVRFGKMYYAVPLSRFHVRRRPEADVLDDVDRWLSQVQGLPSMKEPPAAALSALRRVKDAIFDLCQHGGSHRVRELLVAVGQLDRTVSMRSDLRDRIEPLVLRSPSWIERAWPEESREQAEFAIALALATMENVDKVSHRQYFAPVKGGGASARQWADDMAAARVRLAFDSPDFVRGAILLAKRRLLDEERASQNHSEGEASGPLDKRGKLGFHSRERGFAARLEHLVPFWLGRTRDARILDYAWALSAYQGSAPNLASRLPARRTPDWVPYLYALLRIALTSDGELRNAFTRLAGRNLGQPPSIADDFVLPVPRDVFALLGTDRPSDAVRAREILERRFIASGLAIKHRGTDTFGLSPRRVLASAVVPIDRSSLASIAARLWPKDDPAATEAATEATTHS
>NC_017167.1|WP_014465660.1|2800978_2801941_-|type-I-U-CRISPR-associated-protein-Cas7
MAISLDLLNTAPRLLVRAELKPVAGTRFQPTGFPDLGAAEYDHPRELYRMLLVESPQSMANRMEKVCWDDAANDWRAPLKGLPRVDVYDQNGAFLTNSVLEAHRLNSPYILEGKDTTVAQLLKRELGLRSDAQPVDVPKLARTVFKYDPNSVLHGLFLAKKDLAGGRLRLTRMLSAFIEAEDARVAPSGGVKNDRVDPKGDASQGFGNVPFHRDEYVARRIYAYFVFDLALLRSYGLGSLAETFLVLFGLYKIQHFLAEGLRLRTACDFDVEQVEVLRPSGFVLPQAEEIDRELPGLIERLRAEGALSADDLRVRYEVKK
>NC_017167.1|WP_041695499.1|2799365_2800982_-|type-I-U-CRISPR-associated-protein-Cas5/Cas6
MIAIPHKGSGHVVGIEFRFVAGKFHATPWGRHVNEADVEWPPSPWRILRALIGVYYRYSASARYGEAALRQLVEALASEKPMYSLPDAVHTHTKHYMPVAGGRTTLVHDAFLRVEPDAPLGVYWPKVELAEEADALLRHLAPIIPYLGRAESWVEASVAERLPDAFDAVPVEADEAEQMLERAEGELVDLLAPVAPSDWPRLRARWAVGSRKSSLAAAETLFEALLLGTDVLEAERLNLPLGAEHVTYVRRKLDLRHPAPSPRISALRPASNVARFRLVSPVPTRIIHALDVGEAMHAALVGIAAKRGDVPPSLTGKDPENPKEPLREGHRHVFILPTDEDLDGYLDHVLVYQGDPFSDGLVDVLESLRYLYTPDWWPGRPRRWQLYLEGLWRTPPYAERPAEGRSLDVPDGYLRPSRVFTSVTPYLHPWHWKKRGAKFGPADQIREELRRRGLPEPVSVEELGHIRLGGLSYDARKFRKLRYGARQEIPARKGGLWRIEFADPVFGPIALGVNCHFGMGLFYAGEVAHMPLQTVLER
>NC_017167.1|WP_193352809.1|2798397_2799183_+|sulfite-exporter-TauE/SafE-family-protein
MNWEMFATLLAIGFAGSVLAGMVGVGGAIVKYPLLLYLPPLLGVGIFSAHQVAGISSVQVMCASLAAVWAYRKSGYLHRRLIGDMGLAMLAGSFVGAYMAHFYPESVVNLIYALLATAATLIMLRPSGSDELRGDVDEVDYPRPLAVGLGALVGLFSGVVGSAGAFLLMPILLGVLRIPTRVAIASSIAITFVASLGGFVGKWAAHEVMWGPALVLAWASAVGAPLGAKLGKRMDARWLRWLLAALIAATCVRIWWTVLAE
>NC_017167.1|WP_041695502.1|2812637_2814359_-|phosphomethylpyrimidine-synthase-ThiC
MTTGFDPYFPSSRKVYIGGARPDLRVPMREIALEATSSSAGLRPNDPIRVYDTSGPYTDPDIKVDPRRGLPALRARWIDERADTEWKEPSRPLEADPSLIPFERRVRRAKPGRIVTQMHYAKRGIVTPEMEFVAIREGMDPEFVRDEVARGRAIIPANINHPELEPMIIGRKFHVKVNANIGNSIVSSSLEEEVEKMRWAILWGADTVMDLSTGRHIHETREWILRNSPVPIGTVPIYQALEKVGGSIPDLSWEVYRDTLIEQAEQGVDYFTIHAGVLLRYIPLTANRVTGIVSRGGSIMAAWCLAHHEENFLYTHFDEICEILAAYDVSISLGDGLRPGAIADANDEAQFAELETLGELTKRAWAHDVQVMIEGPGHIPMHKIEENVVREREICHDAPFYTLGPIVTDIAPGYDHITSAIGAAMIAWHGTAMLCYVTPKEHLGLPNRDDVKEGLIAYKIAAHAADVAKGHPRAQHWDDALSKARFEFRWRDQFHLALDPIRAESFHDETLPAEPAKTAHFCSMCGPKFCSMRITQDLRAYAEAHGLTPDDAIAVGMRERAEAFRAKGRDVYR
>NC_017167.1|WP_014465671.1|2814765_2816238_-|cytosine-permease
MATADELRHTAQVDEAFRLETEGNGIIAEHRRHGMPRELFYVWFAAVLTFTGVVTGQLFTGVFGLNVWESLLIVLLCSISFAALGLYVATGPRAGTVTLTISRAAFGVHGGKIPAFFSWFTAVGWESVTMVLTVWAMLSLAQYVGLPSTGVGPTLVALVITLFLTYLVPILGHATLVVMQRVLAIVLAACTVLVLFAVLPDVKWNFNPPASALAAHGVFPTFLLALSVGLASTFYGWANFAADYSRYLPKETKTSRMVWATFLGGGLANFIMMGLGVVLGTVISAKAFSANPVMAIAKAIPEWAAIPFLIVVVLGDICANYLNAYSSGMSFLSMGIRLKRHFAVALDGAICTAIGIYALFFSNNFVDFFENFLDLMITVMGPWAAIYIVHHFAVRGRYAADDLVDASPTSAYWYNGGFNWRAIVAFVVGAVATFLSVNSALWQSPLTNAWFGGADVSAYAAPIVTGLVYLLLIAPRRERVKAPKAEVKAS
>NC_017167.1|WP_041695503.1|2816581_2817373_-|membrane-protein
MSTARVSTRRIRPMVSKVPEITVWFWIVKLLTTAMGEATSDFLVLHLNKYLAVLLGAVAFGGAFWFQYRAKRYIPYIYWSFVTMVAVFGTMVADAIHIVLGVPYWASTSAFAIFLAAVFITWYRTERTLDIHSIVTRRRELFYWAAVLATFAMGTACGDMTATTLHLGYFASGILFIVLFGAPFVLKRWAGMNEIFAFWFSYVMTRPLGASLADWLGVEKAYGGLGFGRGAVALVTTVVIVVLVAYLTITSKDRSNESLVSNL
>NC_017167.1|WP_014465673.1|2817450_2818263_-|Dam-family-site-specific-DNA-(adenine-N6)-methyltransferase
MKPFLKWAGGKYRLLPYIQRALPPGRRLIEPFVGSGAVFLNTSYDAYVLSDINADVIAVYRVLSVCGEAFIEDCRRLFVPENNSPEAYYALREEFNASRDPVRRAALFVYLNRHGYNGLCRYNAEGRFNVPFGKYRRPYFPEREMRYFREKARRAEFLCGDFRAVMRMAEPGDVVYCDPPYVPLSKTANFRQYAAQGFGEGEQRDLARIAEELADRGIPVLISNHLTPFTERAYHRAECCQLQVRRAISCQGARRGYAPEVLALFTPRSP
>NC_017167.1|WP_014465674.1|2818412_2818616_-|heavy-metal-associated-domain-containing-protein
MVITTIRVKGMTCDGCVRSVTRALSAVEGVSHVDVSLEKGEAVVTHADSTPVSAIRTAVEEAGYDVE
>NC_017167.1|WP_193352837.1|2818656_2818917_-|metal-sensitive-transcriptional-regulator
MKADLSRRLRRIEGQVRGLQKMVEEDRYCVDILVQIAAVKSALHQVGLSILESHTRGCVAEALQQRDREQEKVDELIQVLRQFTKL
>NC_017167.1|WP_041695946.1|2820595_2821147_+|alkaline-shock-response-membrane-anchor-protein-AmaP
MNWFDRLLLFILSVVALILGVAVVLIGAAVPIGWAQMELTRQPYNTVTMVVGGVTALIAIRFLFFRRRRRDPKLDSVMVSGDHGPIRIAYDTIVQLANRRGSQLRGMASFETVVRQGQGGLILTLRMRVLPDIDIAALAKEAQNAVKSYLEETTHVPVERVLVQVTELGDSNRAMRVWSGTGA
>NC_017167.1|WP_041695505.1|2821139_2821394_+|DUF2273-domain-containing-protein
MRETLRGAWEWFVNLPHRYHGLILGVAVWVVWMIVGFWRMVLLAVLAALFYWFGRLWEQEGTIAGIAERLLAQLASRRRPRDGM
>NC_017167.1|WP_014465681.1|2821464_2821839_-|Asp23/Gls24-family-envelope-stress-response-protein
MPKTVETSLGKVQIAEEVVAKIAGMAALECPGLAGMAPRRQVMDRLNEVLRRENLERGVDVQIGPNGDDVKVGLYIIVQYGVNIYDTAVNVQERVADALNRYIGMDNTQIHVYVQGVDFGDANR
>NC_017167.1|WP_014465682.1|2822028_2822523_+|Lrp/AsnC-family-transcriptional-regulator
MNDALRLKICDLLHENAKLSPETIARMLGETPDVIENTIRELEQEKVILRYSAVVNWDKLPVNQVTAVIDVKVLPQREVGFDAIARKIYRFDEVKSVSLMSGGYDLQVTVVGRDLREVSRFVSEKLATLENVTSTATHFLLKTYKSDGVIYDDTDGERRLMITP

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Crispr_ID: NC_017167_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017167_6

3039367-3040720

TypeI-A

Consensus_repeat	Method
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	PILER-CR
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	CRISPRCasFinder
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	CRT

18 spacers

c2c9_V-U4,csa3,cas8u1,cas3,csb2gr5,csb1gr7

The CRISPR arrays of NC_017167_6

>merge|NC_017167|6|3039367-3040720|PILER-CR,CRISPRCasFinder,CRT
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGCTTTTCGCCCAAAGGTCAGCACCTAACCTTCGTCCGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGTTTATTCACCTGGCCCCGGCTCGTTTGAGAATGAGAGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGCCGAGAATGGCGCGCGTGTGATGAAGGCCGTCTTCACGGGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGCTCCTTCGCATCCAAAGACAAGATTGATGGCTGGCAGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGACCCGACAATGCGAAATGTGTGCGATGGTATGGCACGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGGCCAAGATCGTGCACAAGAGCGGCAAACCGTATCATGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGAATGTGCACGTCGCGCTCGTCGTCACCAGCGAGTTCGGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGGGCGCCGCGGCCATGGGGCTTGCCATGGGCTCGAAGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGACATCGGATGCAAGCAGGCCCTCAAGGCCGCCGTGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGAGATAGAAGGCCTTCGAGTTCCCCCCCCTGGATGTCGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGGACATAGAGTGCTGGACGATCTGGATGATGCACTTGAGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGCTCCTCCCCGGTGGCCGCGAAAACCGCACGACAGCCGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGCAGGCATTCGTGCCATAACAGTACCCGTTCCTCACGCAGTTGATCCGCCGACATCGTCGGCGGCCCCATTGAAGCTACGGATCGTCCTGCTCCGGCATCACACCGTACTTGGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGCGGGAATTGCTCCAGGAGAGCCCGGATCTCCTGTGCGCAGGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGCCGAGTGATGGGGGCGAAGTCGAACTCTCCGTTTTCCAGTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGCAGTACCTCCTGCGCCTCCAGCACCACCATTTCCACGTTGATCCGCCGAGATCGTCGTTGGCCTCATTGAAGCCCGAAACCTACTTCCGATGTTTGTGCCGCCTGGCGCGTTGATCCGCCAAGACAGTCGCCGCCCGGGCTAGACG

>NC_017167|6|3|3039367-3040574|PILER-CR
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GCTTTTCGCCCAAAGGTCAGCACCTAACCTTCGTCC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GTTTATTCACCTGGCCCCGGCTCGTTTGAGAATGAGA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GCCGAGAATGGCGCGCGTGTGATGAAGGCCGTCTTCACGG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GCTCCTTCGCATCCAAAGACAAGATTGATGGCTGGCA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GACCCGACAATGCGAAATGTGTGCGATGGTATGGCAC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GGCCAAGATCGTGCACAAGAGCGGCAAACCGTATCAT
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GAATGTGCACGTCGCGCTCGTCGTCACCAGCGAGTTCG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GGGCGCCGCGGCCATGGGGCTTGCCATGGGCTCGAA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GACATCGGATGCAAGCAGGCCCTCAAGGCCGCCGT
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GAGATAGAAGGCCTTCGAGTTCCCCCCCCTGGATGTC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GACATAGAGTGCTGGACGATCTGGATGATGCACTTGA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	CTCCTCCCCGGTGGCCGCGAAAACCGCACGACAGCC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	CAGGCATTCGTGCCATAACAGTACCCGTTCCTCACGCA
GTTGATCCGCCGACATCGTCGGCGGCCCCATTGAAG	CTACGGATCGTCCTGCTCCGGCATCACACCGTACTTG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	CGGGAATTGCTCCAGGAGAGCCCGGATCTCCTGTGCGCAG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	CCGAGTGATGGGGGCGAAGTCGAACTCTCCGTTTTCCA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG

>NC_017167|6|6|3039367-3040720|CRISPRCasFinder
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	CTTTTCGCCCAAAGGTCAGCACCTAACCTTCGTCC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	TTTATTCACCTGGCCCCGGCTCGTTTGAGAATGAGA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	CCGAGAATGGCGCGCGTGTGATGAAGGCCGTCTTCACGG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	CTCCTTCGCATCCAAAGACAAGATTGATGGCTGGCA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	ACCCGACAATGCGAAATGTGTGCGATGGTATGGCAC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	GCCAAGATCGTGCACAAGAGCGGCAAACCGTATCAT
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	AATGTGCACGTCGCGCTCGTCGTCACCAGCGAGTTCG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	GGCGCCGCGGCCATGGGGCTTGCCATGGGCTCGAA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	ACATCGGATGCAAGCAGGCCCTCAAGGCCGCCGT
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	AGATAGAAGGCCTTCGAGTTCCCCCCCCTGGATGTC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGG	ACATAGAGTGCTGGACGATCTGGATGATGCACTTGA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	TCCTCCCCGGTGGCCGCGAAAACCGCACGACAGCC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	AGGCATTCGTGCCATAACAGTACCCGTTCCTCACGCA
GTTGATCCGCCGACATCGTCGGCGGCCCCATTGAAGC	TACGGATCGTCCTGCTCCGGCATCACACCGTACTTG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	GGGAATTGCTCCAGGAGAGCCCGGATCTCCTGTGCGCAG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	CGAGTGATGGGGGCGAAGTCGAACTCTCCGTTTTCCA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAGC	AGTACCTCCTGCGCCTCCAGCACCACCATTTCCAC
GTTGATCCGCCGAGATCGTCGTTGGCCTCATTGAAGC	CCGAAACCTACTTCCGATGTTTGTGCCGCCTGGCGC
GTTGATCCGCCAAGACAGTCGCCGCCCGGGCTAGACG

>NC_017167|6|3|3039367-3040719|CRT
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GCTTTTCGCCCAAAGGTCAGCACCTAACCTTCGTCC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GTTTATTCACCTGGCCCCGGCTCGTTTGAGAATGAGA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GCCGAGAATGGCGCGCGTGTGATGAAGGCCGTCTTCACGG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GCTCCTTCGCATCCAAAGACAAGATTGATGGCTGGCA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GACCCGACAATGCGAAATGTGTGCGATGGTATGGCAC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GGCCAAGATCGTGCACAAGAGCGGCAAACCGTATCAT
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GAATGTGCACGTCGCGCTCGTCGTCACCAGCGAGTTCG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GGGCGCCGCGGCCATGGGGCTTGCCATGGGCTCGAA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GACATCGGATGCAAGCAGGCCCTCAAGGCCGCCGT
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GAGATAGAAGGCCTTCGAGTTCCCCCCCCTGGATGTC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	GACATAGAGTGCTGGACGATCTGGATGATGCACTTGA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	CTCCTCCCCGGTGGCCGCGAAAACCGCACGACAGCC
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	CAGGCATTCGTGCCATAACAGTACCCGTTCCTCACGCA
GTTGATCCGCCGACATCGTCGGCGGCCCCATTGAAG	CTACGGATCGTCCTGCTCCGGCATCACACCGTACTTG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	CGGGAATTGCTCCAGGAGAGCCCGGATCTCCTGTGCGCAG
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	CCGAGTGATGGGGGCGAAGTCGAACTCTCCGTTTTCCA
GTTGATCCGCCGAGATCGTCGGCGGCCCCATTGAAG	CAGTACCTCCTGCGCCTCCAGCACCACCATTTCCAC
GTTGATCCGCCGAGATCGTCGTTGGCCTCATTGAAG	CCCGAAACCTACTTCCGATGTTTGTGCCGCCTGGCGC
GTTGATCCGCCAAGACAGTCGCCGCCCGGGCTAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017167.1\|WP_041695547.1\|3041854_3044881_-\|type-I-U-CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09696_cas3_CAS-I-U	gnl\|CDD\|187827
NC_017167.1\|WP_014465897.1\|3030804_3031557_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NC_017167.1\|WP_014465904.1\|3036526_3037681_+\|transposase	c2c9_V-U4	-	gnl\|CDD\|223747
NC_017167.1\|WP_014465895.1\|3025733_3029633_-\|glycoside-hydrolase-family-13-protein	unknown	unknown	gnl\|CDD\|200477
NC_017167.1\|WP_041695546.1\|3033867_3035265_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129965
NC_017167.1\|WP_014463112.1\|3047821_3049174_+\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NC_017167.1\|WP_014465909.1\|3040866_3041880_-\|hypothetical-protein	cas8u1	mkCas0114_cas8u1_CAS-I-U	unknown
NC_017167.1\|WP_158306753.1\|3032258_3033455_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340891
NC_017167.1\|WP_014465918.1\|3053409_3055749_+\|alpha-xylosidase	unknown	unknown	gnl\|CDD\|236731
NC_017167.1\|WP_014465906.1\|3038283_3038991_-\|DUF969-domain-containing-protein	unknown	unknown	gnl\|CDD\|368767
NC_017167.1\|WP_014465914.1\|3049498_3049645_-\|hypothetical-protein	unknown	unknown	unknown
NC_017167.1\|WP_014465903.1\|3035967_3036555_+\|IS607-family-transposase	unknown	unknown	gnl\|CDD\|225296
NC_017167.1\|WP_014465911.1\|3044855_3046373_-\|type-I-U-CRISPR-associated-protein-Cas5/Cas6	csb2gr5	cls000315_csb2gr5_CAS-I-U	gnl\|CDD\|274005
NC_017167.1\|WP_041695973.1\|3046369_3047590_-\|type-I-U-CRISPR-associated-protein-Cas7	csb1gr7	pfam09617_csb1gr7_CAS-I-U	gnl\|CDD\|378223
NC_017167.1\|WP_041695550.1\|3051093_3052221_-\|glutamate-5-kinase	unknown	unknown	gnl\|CDD\|235460
NC_017167.1\|WP_014465898.1\|3031559_3032192_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240048
NC_017167.1\|WP_014465896.1\|3029838_3030771_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NC_017167.1\|WP_014465900.1\|3033486_3033825_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_017167.1\|WP_014465915.1\|3049810_3051097_-\|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|234685
NC_017167.1\|WP_041695551.1\|3052256_3053123_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257

Protein	Function_ID	Function_description	E-value
NC_017167.1\|WP_041695547.1\|3041854_3044881_-\|type-I-U-CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187827	cd09696, Cas3_I, CRISPR/Cas system-associated protein Cas3; Distinct Cas3 family with HD domain fused to C-termus of Helicase domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DNA helicase Cas3; This protein includes both DEAH and HD motifs; signature gene for Type I.	1.68013e-76
NC_017167.1\|WP_014465897.1\|3030804_3031557_+\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	8.54621e-43
NC_017167.1\|WP_014465904.1\|3036526_3037681_+\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.78092e-66
NC_017167.1\|WP_014465895.1\|3025733_3029633_-\|glycoside-hydrolase-family-13-protein	gnl\|CDD\|200477	cd11338, AmyAc_CMD, Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins. Cyclomaltodextrinase (CDase; EC3.2.1.54), neopullulanase (NPase; EC 3.2.1.135), and maltogenic amylase (MA; EC 3.2.1.133) catalyze the hydrolysis of alpha-(1,4) glycosidic linkages on a number of substrates including cyclomaltodextrins (CDs), pullulan, and starch. These enzymes hydrolyze CDs and starch to maltose and pullulan to panose by cleavage of alpha-1,4 glycosidic bonds whereas alpha-amylases essentially lack activity on CDs and pullulan. They also catalyze transglycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules. Since these proteins are nearly indistinguishable from each other, they are referred to as cyclomaltodextrinases (CMDs). The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	6.59463e-175
NC_017167.1\|WP_041695546.1\|3033867_3035265_-\|MFS-transporter	gnl\|CDD\|129965	TIGR00887, Inorganic_phosphate_transporter_PHO84, phosphate:H+ symporter. This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions].	1.44954e-108
NC_017167.1\|WP_014463112.1\|3047821_3049174_+\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.78865e-26
NC_017167.1\|WP_158306753.1\|3032258_3033455_+\|MFS-transporter	gnl\|CDD\|340891	cd17333, MFS_FucP_MFSD4_like, Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins. This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.15083e-35
NC_017167.1\|WP_014465918.1\|3053409_3055749_+\|alpha-xylosidase	gnl\|CDD\|236731	PRK10658, PRK10658, putative alpha-glucosidase; Provisional.	0
NC_017167.1\|WP_014465906.1\|3038283_3038991_-\|DUF969-domain-containing-protein	gnl\|CDD\|368767	pfam06149, DUF969, Protein of unknown function (DUF969). Family of uncharacterized bacterial membrane proteins.	2.95942e-108
NC_017167.1\|WP_014465903.1\|3035967_3036555_+\|IS607-family-transposase	gnl\|CDD\|225296	COG2452, COG2452, Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair].	7.26523e-58
NC_017167.1\|WP_014465911.1\|3044855_3046373_-\|type-I-U-CRISPR-associated-protein-Cas5/Cas6	gnl\|CDD\|274005	TIGR02165, CRISPR-associated_protein_GSU0054_family, CRISPR-associated protein GSU0054/csb2, Dpsyc system. This model represents a CRISPR-associated protein from the Dpsyc subtype (a type I-C variant), named for Desulfotalea psychrophila LSv54. CRISPR systems confer resistance in prokaryotes to invasive DNA or RNA, including phage and plasmids. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associated proteins, have low levels of sequence identify, have sequence relationships that suggest lateral transfer, and show some sequence similarity to DNA-active proteins such as helicases and repair proteins.	1.22733e-66
NC_017167.1\|WP_041695973.1\|3046369_3047590_-\|type-I-U-CRISPR-associated-protein-Cas7	gnl\|CDD\|378223	pfam09617, Cas_GSU0053, CRISPR-associated protein GSU0053 (Cas_GSU0053). This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).	1.61779e-56
NC_017167.1\|WP_041695550.1\|3051093_3052221_-\|glutamate-5-kinase	gnl\|CDD\|235460	PRK05429, PRK05429, gamma-glutamyl kinase; Provisional.	3.01951e-180
NC_017167.1\|WP_014465898.1\|3031559_3032192_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240048	cd04692, Nudix_Hydrolase_33, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.14393e-33
NC_017167.1\|WP_014465896.1\|3029838_3030771_+\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	9.32449e-99
NC_017167.1\|WP_014465900.1\|3033486_3033825_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.4476e-16
NC_017167.1\|WP_014465915.1\|3049810_3051097_-\|glutamate-5-semialdehyde-dehydrogenase	gnl\|CDD\|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	0
NC_017167.1\|WP_041695551.1\|3052256_3053123_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.25576e-104

>NC_017167.1|WP_014465906.1|3038283_3038991_-|DUF969-domain-containing-protein
MVVMGVLLVIVGFALRINPLLVVTVAGIVTGLLAHESPYAILSQFGAAFAKDRYMAVFVATLPVIGLLERHGLREQAQRLVAKIRAATTGRILNAYLFIREVAAALGLTSIGGPAQMVRPVVAPMAEGAAEAAYGELPHHVRDHIRAHAAAVDNVGLFFGEDVFVAVGAVLLMKGVFDQFHIHSTPILMGLWALPTATAVFIVHSVRLYLLDRRLRRWLSGGVNAAPSAGEGVNP
>NC_017167.1|WP_014465904.1|3036526_3037681_+|transposase
MKIHRAYRYELAPNRMQRSLLAKHAGAARFAYNWGLARRIALYEETGQSTNAIEQHRELNRLKKTDFPWMYEVSKCAPQEALRDLDRAFQHFFRGLKEGRRVGFPRFKKKGRDDSFRLTGSIRVLDNAIQLPRLGRIRLKEKPHVEGRILSATVKREADRWYVSLSAETEIPDPVPPSGEPVDVDLGVSWFLTLSDGTKIEAPKPLARYLRRLRRLSKRHSRKKPGSRNRRKSALALARLHRKIRNIRQDFLHKVTTELAKTKRVIVIEDLHVRGMVQNRALARAISDVGFGEFRRMLTYKCAWYGSRELIVAPRFYASSKTCSACGYVISELPLSAREWTCPACSTRHDRDINAAKNLLRISTASSAGSDACGDPSDGAALGC
>NC_017167.1|WP_014465903.1|3035967_3036555_+|IS607-family-transposase
MKLSDWARKNGITYKTAWRWVKEGRMPVPFEQTPSGTILVREPESSTANAVALYARVSSADQKDDLDRQIARLMEFATEQKLVVFKAVTEIGSGLNGHRPKLMKLLSNPNAHTIVVEHRDRLMRFGFEYVEAALAAQGRRILVVEPGEVKDDLVQDMIEVLTSFCARLYGRRSARHRAKRALEVFKREDSSGVSV
>NC_017167.1|WP_041695546.1|3033867_3035265_-|MFS-transporter
MSVNPKVLEAMDESRLSGFHWKTMFTAGMGFFTDAYDLFIIGTVTAILTPLWHLSTAQLSILNSTSLAAAALGALFFGKLMDKLGRKAMYGFEVIMLAVGAILSACAPSFIWLVIFRFIVGLGVGGDYPTSSVIMTEYSNRKNRGFMVTMVFAMQGLGLLAGPLVASILLSVGIPHDIAWRIMLALGAIPAASVIYLRRRMPESPRYLMAVKQDADAAASAAQQLTGQAVRALEESASRAVIAKQSLWTPKHLFRLLGTAGSWFLIDVAFYGNSVSSQLILKALLPHAQLVTTTLVATAIFMVAALPGYFVAANLMDKWGRKFIQSLGFVVMAAAYAALFLVPSIAKMPILFLLLYAVSYFFIEFGPNTTTFLVPSEAFPTNLRGTAHGISAAAGKIGAFLGAFVLPGILKAAGLSVTMGLLAGVALLGALLTLLAVPEMKQKSLEDTEEIQVSPQATAHHSIVG
>NC_017167.1|WP_014465900.1|3033486_3033825_-|winged-helix-turn-helix-transcriptional-regulator
MTHGPDMPEDLCMRCLAMLGEPQRLRILRALAEGEQTAGALSERLGVRQNTLSHHMRQLREHGLVEVRRHPHDERYTFYRLNGRRLRALSAVLTDWAARAEAEQDVSGRRSS
>NC_017167.1|WP_158306753.1|3032258_3033455_+|MFS-transporter
MPMYVWLACGLYWMNGMATVALGSVMPLAIQHLHATYVFGSDLVLLQFVGYWIGVPLSSLAVRRVGYRGTIVGSSLITAAASAGFTAWPEPLAYLVCSLANGIGMALMQATVSTSLIEWFPARRAVIMSRTEAAFGLGCVLGPAFASACMAAGEWRIAFVLVAAAATALAIGAIFTPMAVQDSGEGPRDAHTDAIHLANRRDRALVLALFMLCVLVYVGVESCVNNFLPAMFVEHFGLPATTASVAVSTFWAAMVAGRMATGWIARKLPYRPYLILAALGTLSTTAAMAATGDAILGYVECVFLGLFMSGIYVVTLVFANHAFPDLTGFVTRFVTFFAGLGGATLPYAFGWTLAKTGSQWANVVLALFAAMLFGVVAWTGWVTKRKSRSRAERVHAAG
>NC_017167.1|WP_014465898.1|3031559_3032192_-|NUDIX-domain-containing-protein
MGKDEREEWLDIFTHEMIPCGKAPRSMVHERGLWHQTFHAWIATGKGPAGRLVIQLRGARKDTNPLRFDVSAAGHLEAGESPEEGVREIEEELGLHAAPGSLHKLGVVAHEARLGSVWDREFNHVYVAIVPELSLEALRPAVDEVAGIYELSVRDFLDLAFGRREEAVLTGYRVLPGHLQKDARTARWTDFVPRSRAYLELLQDFFLGKG
>NC_017167.1|WP_014465897.1|3030804_3031557_+|pirin-family-protein
MAWMKFPGAHRAPLMFYEHARIFPSRTTPYIDPFLLLDHFSIQHPDGFPDHPHRGFEIITYVLKGAVAHADSAGHQSVIPEGGAQHVTAGRGIVHSEMPGTDGIDSGLQLWINIPRSDKGMDPGYEDIPPDALPVDEPAQGVRRKWIVGGGSPLRTHRPMTYQDVEMAAGASYTLEAPAHHQGFIFVLDGAGHLGEEEIPMQKGDLFIWHRADGEAFMPTPVRAEESLRAVMVFGEPVGERPIFNGPFVD
>NC_017167.1|WP_014465896.1|3029838_3030771_+|alpha/beta-hydrolase
MPLDPVIQQVLDQLNRMPAPDYQHLSAQQFRSQQSLFPPVKKEPVAEVREFDMDLPGRTLKVRMYRPEGVEAPYPALVYYHGGGWVVGDLETHDPVCRVLAKDGRAVVFSIDYRLAPEHKFPAAVEDAYDALQWIAERAADFQLDPSRIAVGGDSAGGNLAAVTSILAKERGGPAIAFQLLIYPSTGYDPAHPPASIEENAEGYLLTGGMMLWFRDQYLNSLEELTHPWFSPVLYPDLSGLPPAYIATAQYDPLRDVGKLYAEALQKAGVKVEIENFEDLIHGFAQFYSLSPGATKALLRIAEKLREALA
>NC_017167.1|WP_014465895.1|3025733_3029633_-|glycoside-hydrolase-family-13-protein
MKWKGTVSLATTIVMSAALPFVAFGDARFASTQRSLSVTAMDSSNSSSAAGAAGGGGTAAETYSNAVQIVSGNGFRAGSAATVVLAVNGLTLDASNFKVEVSNSTNGVIDVTNDAALTGLNSITLRLPGGDDGLGAGTYTVTVESGGLSVSTPAGQGLQVMPYTTADTVQWDGIYTSDDPMYVSNPNPSPGQEVTISLRAYSGNLTKVILNCWDTAQNKGFQVEMSPGRTFGPYQLWSATIPASNGGTIYYRFDIYDGTSFACLSGDGLHTSDDINNNFPLPVGTVTLSTLQANPGDTVTVSDPVGDFAGSQDQPNQTVIRFVNSSGETAATVDGTNASWNSVQFTVPQSLPNGLYRVEIDTVAKDADGAVNVEWDRSAELIVGPLPAWMQAYAHDSFQAFYRSPFGAVPTGTPITLRLRAPLSVKSATLRLWGAAGQSGEIDLPMQKLQMPGDELAQQTGVQDINNYTWWTVTIPAADVTTPGTMWYQFMTETDTGQVVYYDDNGAQLEGLGQVGLSSDGPSYQITVYERGFQTPDWLKHAVIYEIMPDRFYNGNIATEENPNTQKGIYVGADGTESLGPIQFHENWDSPPYDPNIPPSSDPKISSLRGNGQWNIDFFGGDLQGIEDKLDYLKSLGVNTLYLMPVFEAESNHKYDTADYFKIDPGFGTQQDWLNLVRAAHAKGFHIILDGVFEDTGSDSVYFNKFGNFNSNGAWQAYLKNQPSLSPYYSWYEWTGNASNPYNSWFQIDTLPLTDTSNPAYQQFVYGGANSVARHWIREGADGWRLDSADNGNFNTSWWSGFRDAVKSIDPNAAIIGEIWNNATNDNGTDWLTGSTFDSVMNYQFRNAVIDFFRGTYNDGNVQHHAVDAEGFNQELMRLYSEYPLQSFYAMMNLVDSQDTMRILTILENAPQPSDLSALQQDEYKPSPADEQLGIERLKLVSDLQFSFPGDPTIFYGDEAGLTGYSDPLNRRTYSWDNQNIDLLNHYRKLGAIRNANPVLQTGDFTPLYAQGMVYAFARTIRNGRDVFGVPAEDATAIVAINNQNQAITVTIPTDGTVADGTTMLDELNNQWYKVQNGGITLTLQPYQGAILVTPSDAPVAYLQEEDSQNEIAWTPVQGAIGYRVWRKNPDGQWVPFGPMLPATDLSVTVERNAYAQTFAVQALFSPADHAQSPVSAPNTVSLPVDVPAVRLSQPIVSGRVAGDRAMLSIAPVSGATQYVIYQRQGDGSYAPVATVSTSGGSAAVGEVPAQGPATSPHATIRVTVPVPAGFSSVTYRVAAQNEDGQAVTDPLTLSISTK
>NC_017167.1|WP_014465909.1|3040866_3041880_-|hypothetical-protein
MTAHEFRLEGLEPDNPLAFFALLGLLRALEAVDLDCEPSERLYPRVQWAPAPLRPVLVVRRSATEDEIAKRAVDGIAQLANHHDFGDHADLNYTQQEAREILSEAIAKAGPHQRYRADLLAALMSDGAVEGKRSKKSESPRIAPTPVCLLFGQGHQHFLKRLRDVPRSRTPDELEDKGRVGAGEEPEQYVQETIFRPWRRDDTMLSSFRWDPNEIARYALMPGNPTDPKYKLGTQYGANRLAAIGISVLSGAPRNRADRTWLTIVGGHYDKDGFTLAWPIWRAPATLAAIRFMLAHPGLRDGGLRHMGVEQVMVSRRIQIEKYFSFTRAQPRFVEAT
>NC_017167.1|WP_041695547.1|3041854_3044881_-|type-I-U-CRISPR-associated-helicase/endonuclease-Cas3
MCTPLDRSEFAAFLQEVHGYQPFPWQVRLLDRLVETGAWPELLKLPTSSGKTTVIDIAVFYLALEADAGANRRAPVRLAFIVDRRLVVDDAYQHAKRLAEKLEAAEPDSVSARVAARLRELSGSSHPLVVRRLRGGVPREDDWARTPIQPTVLCSTVDQVGSRLLFRGYGVSDAMKPVHAGLLGADCHLFVDEAHLVEPLRQTLSWVAMYNGPLWRTDTTIKLPWGYTIMTATPQPGVNQAFELDDENFEHPILSARWSATKPVRLIELKKKTARDKSAPEESLQEADEAEENRRVEALIDEFRTAAQYLQANGVLRPAIAIVVNRVGRARAVFDALRAELASDGWTPMLLMGPARPLDRDAWLTGQLAPIRTRPWPERRDLEHPIAIVATQCIEVGIDIDLDAVITDAAPIDALRQRFGRLNRAGRPTPCLGAIVATPTDLSSRTDDPVYGGAIAEAWAYLKRHAQAGRRGEAPTVDFGLAAFESFVKADPVPDEALSPTEDAPVLMPAHVDLLACTSPVPAADPEVSLYLHGPKRQPDAVSVIWRADIHRALGHRAVFALLQLVLPRSTEAVELPVWAVKMWLRRGSNADADLADVASQMEDEDLDADRASSREVFRWTGDEDTSAWISANDIRPGDTIVLPASYGGLDAYGWNPEETAPVRDLGLQANLPFQGSYFTVRVAPGLVAQEDEARLAAILAEAEAGDWRDVRDGLLEFKLDDDLRASLKRLDAARGRVQAFFDIYGRDAQGRPIGVVLEARRGVAADGVDALSAVPATEDDLFGSITGVPVELEAHCQGVAEAALRFARAVGLPESIQRDLELAGLFHDFGKADRRFQSYLAFGDPLGPDMDAPLLAKSGRPLPYHVRADVGLPDRWRHEALSVALAPRHPRFQEVGDPELVLWLVGTHHGYGRPFFPHDDPASSSGEPYSRTLFGYAVEMAPSDGPQSLAYDWHGVDWAGLYELLKARYGVWGLAYLEAVLRLADHRVSEEEQRMRGVTRDSSRIST
>NC_017167.1|WP_014465911.1|3044855_3046373_-|type-I-U-CRISPR-associated-protein-Cas5/Cas6
MTLVLEIEFLSGSSVAALHPDSEAPDWPPQPDRVFSALVATWAYRGQRPEERMALEWLEALEPPRIEATSAFQRTSYVTYVPPNDRSAVKTRRASDNISDYRSRQPRRFITVRPVSPTVRLLWHGVGADGETERWVSALDALARDTAYVGHSSSLTRCRVYLTDEHVPDHAQEPLRRVYPGRMAELIRSFEAGRRPRVGEWVLPRAKTATRGEPASLFSTTWLVLEHVGGLMPDIRAAALVSQAIRDRVVEGYRAIGAPVSEVVSGRTVHGEPAHDAHLAIVPLPFAGFSHADGRVLGFALVPPRQVDLLRNETWLRALRAICPVDERRGRRVLRVKLDMGEMELSPTLQPTKRSLDPAVYVASPSRIFATVTPMVLNRHVKSGRAPSVLEVMDEVARACAHVGLPRLEEIRVEGLDRPVPAVLATDHSAFEGVPSVLRSRKRPAWLRWQVPPYLQGRPITHAVIQFAEPVSGPVILGAGRYLGLGLCRPLPDGGESSVHALGSL
>NC_017167.1|WP_041695973.1|3046369_3047590_-|type-I-U-CRISPR-associated-protein-Cas7
MNVETLAQMVTSDAAIRRRQRLQPAGGPGDKIFPPTYPGEYQNDPPRHVFERRMVNGEEVWCALVDSVQSQANRMEDALLRAIRKDGLRIPHVVVDFRDKGLLGLSEITSLDAPHRIYDAIMRDSLLDGRPFMESEVGLSLAQASPGNATAILEIAPTALIFGAWHSTGSGGGLGAKFARCLTSEIVAIGVPVDEIPRRDGTLVVRTAGRRTGSRIDPLGILRKVEVYKSDTNWDVVPDRAGKGAKKVRPSEINHGNITPSVDPLGITCDHLEHTFVLSFAGLRRLRFGGDERDRAGRVLLAALGLLAMLEQDRHGYALRSRCDLVPEQPAPLEVVHPDGSTDTLKLDLQGARALYEEAFARAEAAGFRLRREPIRLIPQDKLVAIVMESQKLALSGQGGEAEEEK
>NC_017167.1|WP_014463112.1|3047821_3049174_+|IS1380-family-transposase
MNHLRFIIEESDEVIVTHSGMTLVGVLLDKTRIGERLNQTRLPGMGKPDISNRDVAYSYIGLLCQGKTDFDHIEAFRDDEFFMIALQVDNVPSSPTLRQRLDMVAGKSGWESILREESARLLRALDVTLHPIELGVPAERRTYIPLDIDVSPFDNSGTKKEGVSRTYKGHDGYAPIFAYLGQEGYVVNVQLREGSTHVQKGTSTFLRESIQYARQVTDLPLLVRLDAGNDSAENIAVCRSQDSRAEFIIKRNLRKESPEAWLVIAQRHGTCHEPRPGKKVYHGSLMCPVKGVSEPVRMVFEVIERTMTADGQILLVPDIEVSAYWTSLPDDPAVIIRLYHDHAVMEQFHSEIKTDLDAERLPSGKFATNNLVLHFVCVAYNLLRVIGQESLKRNDAPLRKKAERRRIRTVIQNLMTLAAKMVRHARQTKLKLGYGNRWLPAFRRLYLAFA
>NC_017167.1|WP_014465914.1|3049498_3049645_-|hypothetical-protein
MGTFGGYTRWAVVFLIIFVLFFLLVPAVGAAPAPSCGCAPGAGAYGVY
>NC_017167.1|WP_014465915.1|3049810_3051097_-|glutamate-5-semialdehyde-dehydrogenase
MSVDTTTELVESVRAILRGAQGAKRRMATAPTRVKNEALSHMADAIWARRSEILAANAADVDAARREGQPAARVDRLMLDEARLQQIIEGVREVEALPDPVGEEVERILRPNGLDIRKVRVPMGVIAMIYEARPNVTVDAAALAVKTGNVAVLRGGSEALRSNQALVAAIHDGLRQAGLPEAAVSLVAHVDRDVVDVLIRARGYVDLAIPRGGAGLIRRVVENASVPVIETGVGNCHVYVDRAANFEMATRIVVNAKTQRPSVCNAAETLLVHAEIADAWLPNAARALVDRGVALRACPRALEILRGAGIPAEAAQEADWETEYLDLILAVRVVETLEDAIAHIERYGTQHSEVIVTDDEDAARVFLASIDAAAVYHNASSRFTDGFEFGFGAEIGISTQKMHARGPMGLRELTSYKYVVYGHGQVRE
>NC_017167.1|WP_041695550.1|3051093_3052221_-|glutamate-5-kinase
MSRDGRGRRRVVVKIGSSSLTEADGSLALSRMRQMVSDVARLGRETGCQFVLVSSGAIAAGLGRLGWQRAHISMPEKQAAAAVGQVLLMEHYERLFAEHGIAVGQILMTRADVEDRKRFVNIRNTVMALLQRGVMPIINENDTVAVEEIRFGDNDTLAALVALVAEADTLVLLTDIDGLYTANPRQDPSATRIAEVEVITDEIERIAGGAGSSAGTGGMRTKIAAAKIATQSGVEVVIAHRDEPRVLERVLAGEPVGTRFLASREPVSLRKSWLLHAPKPEGALQVDHGAMRALIAGGKSLLLPGLVQVHGEFQEGAVVELVGPTGAAFGKGISNFSSRDLAEWLEKKRAGEDVHALHEVVHRNDMVIWTEATAG
>NC_017167.1|WP_041695551.1|3052256_3053123_-|fumarylacetoacetate-hydrolase-family-protein
MKLCTYREGGALRLGLVRGDEVVDVAASAAQLGVSVPDTMEAVIAQYAEYQSALEAIAEKGVAAGKLSDLRLAPPVTRPQKIVCVGLNYRKHAEESKMPIPSSPVYFAKFANSLAAHGDEIAIPPVAREVDYEVELVAVIGCRCRDVAEEQALGAVFGYAVGNDLSARDLQMRASQWLYGKAIDGFAPLGPYIATADEVGDPQRLGLRLYLNGELRQNSSTADMIFSVAQVIADLSRIMTLEPGDLVYTGTPEGVILGREEKVWLKPGDEMACEIDGLGRLENRLVAG
>NC_017167.1|WP_014465918.1|3053409_3055749_+|alpha-xylosidase
MKFTDGNWLVREGVSIHPGLAVQEWRQEEDGVLFFVACRPVAHRGHMLDGPMLTCRISFPRPGMVRVEQHHFLGRMHRGPHFPLELNPQPFDAVETEDSVVLRAGEMEVRVRLAPWSIAFYENGRFLTESGPRSTAYVVDHGRPYMRGQLHLSVGENVYGLGERFTAFVKNGQSIDIWNRDGGTGSDQAYKNVPFYLTNRGYGVFVNHPERVWFEIGTEFVSKVQFSVEGEALDYVVIGGGEPKGVIERYTALTGRPALPPMWSFGLWLSTSFTTDYDEETVSQFVDGMASRGIPLSVFHFDCFWMKPFEWCNFAWDTACFPDPAGMLARLKSRGLKICVWINPYIAQKSPLFREAMERGYLLKRQNGDVWQWDLWQPGMGIVDFTNPEARRWYQSHLRRLLDMGVDAFKTDFGERIPTDVVYHDGSDPQKMHNFYCYLYNEAVWEVLRERRGDDAVVFARSATAGGQRFPVHWGGDCRATYESMAETLRGGLSLALCGFGFWSHDIGGFEDTAPAHLYKRWIAFGLFSSHSRLHGSGSYRVPWLFDEESVDVLRHFTRFKLRLMPYLWSCAVEAHRTGVPMLRPMILEFPDDPTCDTLDRQYMLGPSLLVAPVFSETGEVVYYLPEGRWTHLFTGETRQGGRWYRERYDFMSLPVFVREGSILAMGAESEQSDQPYHREVAIHVYPIRPDRRSSYTLFDQRGNEAGTWHAFWDGDDLVLAPQGRSEARCAILHGIDDPAYLAAQGADCRISPEGVVILPRHPQEAVRVAGCRTRWWAE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_017167_1	1.18\|39513\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	39513-39547	35	CP006880	Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence	172969-173003	6	0.829
NC_017167_1	1.18\|39513\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	39513-39547	35	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1545664-1545698	8	0.771
NC_017167_6	6.28\|3040207\|35\|NC_017167\|CRISPRCasFinder	3040207-3040241	35	NZ_CP014308	Burkholderia sp. PAMC 26561 plasmid unnamed1, complete sequence	588490-588524	8	0.771
NC_017167_6	6.28\|3040207\|35\|NC_017167\|CRISPRCasFinder	3040207-3040241	35	NZ_CP014309	Burkholderia sp. PAMC 26561 plasmid unnamed2, complete sequence	246584-246618	8	0.771
NC_017167_6	6.33\|3040576\|35\|NC_017167\|CRISPRCasFinder	3040576-3040610	35	MN694289	Marine virus AFVG_250M1105, complete genome	25412-25446	8	0.771
NC_017167_5	5.1\|2812046\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	2812046-2812080	35	NZ_LR536452	Methylocella tundrae isolate MTUNDRAET4 annotated genome plasmid 3	27938-27972	9	0.743
NC_017167_5	5.1\|2812046\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	2812046-2812080	35	NZ_LR536452	Methylocella tundrae isolate MTUNDRAET4 annotated genome plasmid 3	27949-27983	9	0.743
NC_017167_5	5.4\|2812265\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	2812265-2812299	35	NZ_CP016287	Rhizobium leguminosarum strain Vaf10 plasmid unnamed1, complete sequence	486258-486292	9	0.743
NC_017167_6	6.8\|3039917\|36\|NC_017167\|PILER-CR,CRT	3039917-3039952	36	NZ_CP005190	Sphingobium sp. MI1205 plasmid pMI1, complete sequence	187716-187751	9	0.75
NC_017167_6	6.33\|3040576\|35\|NC_017167\|CRISPRCasFinder	3040576-3040610	35	AP014296	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S27-C59, * SEQUENCING IN PROGRESS *	7877-7911	9	0.743
NC_017167_6	6.33\|3040576\|35\|NC_017167\|CRISPRCasFinder	3040576-3040610	35	MN694467	Marine virus AFVG_250M311, complete genome	16737-16771	9	0.743
NC_017167_6	6.35\|3040575\|36\|NC_017167\|CRT	3040575-3040610	36	MN694467	Marine virus AFVG_250M311, complete genome	16737-16772	9	0.75
NC_017167_5	5.1\|2812046\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	2812046-2812080	35	NZ_LR536452	Methylocella tundrae isolate MTUNDRAET4 annotated genome plasmid 3	27960-27994	10	0.714
NC_017167_5	5.4\|2812265\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	2812265-2812299	35	NC_008381	Rhizobium leguminosarum bv. viciae 3841 plasmid pRL10, complete sequence	106506-106540	10	0.714
NC_017167_5	5.4\|2812265\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	2812265-2812299	35	NZ_CP049734	Rhizobium leguminosarum strain A1 plasmid unnamed1, complete sequence	13122-13156	10	0.714
NC_017167_5	5.4\|2812265\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	2812265-2812299	35	CP049734	Rhizobium leguminosarum strain A1 plasmid pRLa11, complete sequence	130361-130395	10	0.714
NC_017167_5	5.4\|2812265\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	2812265-2812299	35	NZ_CP054024	Rhizobium sp. JKLM12A2 plasmid pPR12A203, complete sequence	195869-195903	10	0.714
NC_017167_5	5.4\|2812265\|35\|NC_017167\|PILER-CR,CRISPRCasFinder,CRT	2812265-2812299	35	NZ_CP054035	Rhizobium sp. JKLM13E plasmid pPR13E04, complete sequence	292411-292445	10	0.714
NC_017167_6	6.22\|3039771\|36\|NC_017167\|CRISPRCasFinder	3039771-3039806	36	NZ_CP019872	Pseudomonas syringae pv. tomato strain B13-200 plasmid pB13-200A, complete sequence	119359-119394	10	0.722
NC_017167_6	6.6\|3039770\|37\|NC_017167\|PILER-CR,CRT	3039770-3039806	37	NZ_CP019872	Pseudomonas syringae pv. tomato strain B13-200 plasmid pB13-200A, complete sequence	119359-119395	11	0.703
NC_017167_6	6.9\|3039989\|35\|NC_017167\|PILER-CR,CRT	3039989-3040023	35	NC_008537	Arthrobacter sp. FB24 plasmid 1, complete sequence	153822-153856	11	0.686
NC_017167_6	6.23\|3039844\|37\|NC_017167\|CRISPRCasFinder	3039844-3039880	37	NZ_AP022607	Mycobacterium branderi strain JCM 12687 plasmid pJCM12687	408137-408173	11	0.703
NC_017167_6	6.25\|3039990\|34\|NC_017167\|CRISPRCasFinder	3039990-3040023	34	NC_008537	Arthrobacter sp. FB24 plasmid 1, complete sequence	153822-153855	11	0.676
NC_017167_6	6.25\|3039990\|34\|NC_017167\|CRISPRCasFinder	3039990-3040023	34	NC_010492	Arthrobacter sp. Chr15 plasmid pChr15, complete sequence	3322-3355	11	0.676

1. spacer 1.18|39513|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to CP006880 (Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence) position: , mismatch: 6, identity: 0.829

cagcgcaaggccaggacttcgccgacgcgcatgcc	CRISPR spacer
caagccgaggcaaggacttcgccggcgcgcatgcc	Protospacer
**.  *.**** ************.**********

2. spacer 1.18|39513|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 8, identity: 0.771

cagcgcaaggccaggacttcgccgacgcgcatgcc	CRISPR spacer
tcgcgcacggccaggacatcgccgacgcgctcggg	Protospacer
. ***** ********* ************ .*

3. spacer 6.28|3040207|35|NC_017167|CRISPRCasFinder matches to NZ_CP014308 (Burkholderia sp. PAMC 26561 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.771

tcctccccggtggccgcgaaaaccgcacgacagcc-	CRISPR spacer
tccgccccggttgccgcgaaaaccg-acgctatttt	Protospacer
*** ******* ************* *** .* ..

4. spacer 6.28|3040207|35|NC_017167|CRISPRCasFinder matches to NZ_CP014309 (Burkholderia sp. PAMC 26561 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.771

tcctccccggtggccgcgaaaaccgcacgacagcc-	CRISPR spacer
tccgccccggttgccgcgaaaaccg-acgctatttt	Protospacer
*** ******* ************* *** .* ..

5. spacer 6.33|3040576|35|NC_017167|CRISPRCasFinder matches to MN694289 (Marine virus AFVG_250M1105, complete genome) position: , mismatch: 8, identity: 0.771

agtacctcctgcgcctccagcaccaccatttccac	CRISPR spacer
accacctcctccgcctccaccaccaccaccgccaa	Protospacer
* .******* ******** ********.. ***

6. spacer 5.1|2812046|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR536452 (Methylocella tundrae isolate MTUNDRAET4 annotated genome plasmid 3) position: , mismatch: 9, identity: 0.743

gatagcccggatgaggccctgatgtggcccgccaa	CRISPR spacer
tgtggcccggatgtggcccggatgtggcccgggtt	Protospacer
 .*.********* ***** ***********

7. spacer 5.1|2812046|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR536452 (Methylocella tundrae isolate MTUNDRAET4 annotated genome plasmid 3) position: , mismatch: 9, identity: 0.743

gatagcccggatgaggccctgatgtggcccgccaa	CRISPR spacer
tgtggcccggatgtggcccggatgtggcccggatg	Protospacer
 .*.********* ***** ***********   .

8. spacer 5.4|2812265|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016287 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.743

tggatcatgccccaggaagtcccgcag----acaattcc	CRISPR spacer
cagatcatgccccagggagtcccgcagtagtgcga----	Protospacer
..**************.**********    .*.*

9. spacer 6.8|3039917|36|NC_017167|PILER-CR,CRT matches to NZ_CP005190 (Sphingobium sp. MI1205 plasmid pMI1, complete sequence) position: , mismatch: 9, identity: 0.75

gggcgccgcggccatggggcttgccatgggctcgaa	CRISPR spacer
ggacgccgcggccatggggctcgccacccactatat	Protospacer
**.******************.****.  .**  *

10. spacer 6.33|3040576|35|NC_017167|CRISPRCasFinder matches to AP014296 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S27-C59, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.743

agtacctcctgcgcctccagcaccaccatttccac-----	CRISPR spacer
tgcacctccagcgcctccagcaccacca-----gcaaatg	Protospacer
 *.****** ******************     .*

11. spacer 6.33|3040576|35|NC_017167|CRISPRCasFinder matches to MN694467 (Marine virus AFVG_250M311, complete genome) position: , mismatch: 9, identity: 0.743

agtacctcctgcgcctccagcaccaccatttccac	CRISPR spacer
ggttccacctgcgcctccagcaccacctgtactgt	Protospacer
.** ** ********************  * *...

12. spacer 6.35|3040575|36|NC_017167|CRT matches to MN694467 (Marine virus AFVG_250M311, complete genome) position: , mismatch: 9, identity: 0.75

cagtacctcctgcgcctccagcaccaccatttccac	CRISPR spacer
cggttccacctgcgcctccagcaccacctgtactgt	Protospacer
*.** ** ********************  * *...

13. spacer 5.1|2812046|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR536452 (Methylocella tundrae isolate MTUNDRAET4 annotated genome plasmid 3) position: , mismatch: 10, identity: 0.714

gatagcccggatgaggccctgatgtggcccgccaa	CRISPR spacer
cgcggcccggatgtggcccggatgtggcccggatg	Protospacer
 ...********* ***** ***********   .

14. spacer 5.4|2812265|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to NC_008381 (Rhizobium leguminosarum bv. viciae 3841 plasmid pRL10, complete sequence) position: , mismatch: 10, identity: 0.714

tggatcatgccccaggaagtcccgcag----acaattcc	CRISPR spacer
cagatcatcccccagggagtcccgcagtagtgcga----	Protospacer
..****** *******.**********    .*.*

15. spacer 5.4|2812265|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049734 (Rhizobium leguminosarum strain A1 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

tggatcatgccccaggaagtcccgcag----acaattcc	CRISPR spacer
cagatcatcccccagggagtcccgcagtagtgcga----	Protospacer
..****** *******.**********    .*.*

16. spacer 5.4|2812265|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to CP049734 (Rhizobium leguminosarum strain A1 plasmid pRLa11, complete sequence) position: , mismatch: 10, identity: 0.714

tggatcatgccccaggaagtcccgcag----acaattcc	CRISPR spacer
cagatcatcccccagggagtcccgcagtagtgcga----	Protospacer
..****** *******.**********    .*.*

17. spacer 5.4|2812265|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054024 (Rhizobium sp. JKLM12A2 plasmid pPR12A203, complete sequence) position: , mismatch: 10, identity: 0.714

tggatcatgccccaggaagtcccgcag----acaattcc	CRISPR spacer
cagatcatcccccagggagtcccgcagtagtgcga----	Protospacer
..****** *******.**********    .*.*

18. spacer 5.4|2812265|35|NC_017167|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054035 (Rhizobium sp. JKLM13E plasmid pPR13E04, complete sequence) position: , mismatch: 10, identity: 0.714

tggatcatgccccaggaagtcccgcag----acaattcc	CRISPR spacer
cagatcatcccccagggagtcccgcagtagtgcga----	Protospacer
..****** *******.**********    .*.*

19. spacer 6.22|3039771|36|NC_017167|CRISPRCasFinder matches to NZ_CP019872 (Pseudomonas syringae pv. tomato strain B13-200 plasmid pB13-200A, complete sequence) position: , mismatch: 10, identity: 0.722

gccaagatcgtgcacaagagcggcaaaccgtatcat	CRISPR spacer
gccaagatcgtccacaagtgcggcaaccgccgctac	Protospacer
*********** ****** ******* *  ....*.

20. spacer 6.6|3039770|37|NC_017167|PILER-CR,CRT matches to NZ_CP019872 (Pseudomonas syringae pv. tomato strain B13-200 plasmid pB13-200A, complete sequence) position: , mismatch: 11, identity: 0.703

ggccaagatcgtgcacaagagcggcaaaccgtatcat	CRISPR spacer
cgccaagatcgtccacaagtgcggcaaccgccgctac	Protospacer
 *********** ****** ******* *  ....*.

21. spacer 6.9|3039989|35|NC_017167|PILER-CR,CRT matches to NC_008537 (Arthrobacter sp. FB24 plasmid 1, complete sequence) position: , mismatch: 11, identity: 0.686

gacatcggatgcaagcaggccctcaaggccgccgt	CRISPR spacer
gcttacggatccaagcaggccctccaggccctgag	Protospacer
* .  ***** ************* ***** . .

22. spacer 6.23|3039844|37|NC_017167|CRISPRCasFinder matches to NZ_AP022607 (Mycobacterium branderi strain JCM 12687 plasmid pJCM12687) position: , mismatch: 11, identity: 0.703

aatgtgcacgtcgcgctcgtcgtcaccagcgagttcg	CRISPR spacer
atcgcagtacccgcgctcgtcgtcaccggcgagtgcg	Protospacer
* .*..    .****************.****** **

23. spacer 6.25|3039990|34|NC_017167|CRISPRCasFinder matches to NC_008537 (Arthrobacter sp. FB24 plasmid 1, complete sequence) position: , mismatch: 11, identity: 0.676

acatcggatgcaagcaggccctcaaggccgccgt	CRISPR spacer
cttacggatccaagcaggccctccaggccctgag	Protospacer
 .  ***** ************* ***** . .

24. spacer 6.25|3039990|34|NC_017167|CRISPRCasFinder matches to NC_010492 (Arthrobacter sp. Chr15 plasmid pChr15, complete sequence) position: , mismatch: 11, identity: 0.676

acatcggatgcaagcaggccctcaaggccgccgt	CRISPR spacer
taggtgcgtgcaagcaggccttcaagggcgccta	Protospacer
  . .* .************.****** ****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

325725 : 376649

Bacillus_phage(37.5%)

transposase,integrase

attL 312386:312402|attR 387128:387144

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
312386:312402	attL	NA	NA	NA	NA
WP_041695629.1\|325725_326541_+\|transposase	transposase	NA	NA	NA	NA
WP_193352812.1\|328781_330476_+	2-isopropylmalate synthase	NA	NA	NA	NA
WP_041694874.1\|330552_331056_+	glutathione peroxidase	Q6VZR0	Canarypox_virus	3.6e-25	41.0
WP_041694875.1\|338658_339210_+	hypothetical protein	NA	NA	NA	NA
WP_041694876.1\|339206_339893_-	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	2.9e-25	36.5
WP_041694877.1\|340431_342123_+	hypothetical protein	NA	NA	NA	NA
WP_041694878.1\|342261_344301_+	hypothetical protein	NA	NA	NA	NA
WP_014463230.1\|344287_344710_+	hypothetical protein	NA	NA	NA	NA
WP_148260095.1\|344936_347981_+	hypothetical protein	NA	NA	NA	NA
WP_158306708.1\|348066_349527_+	glycosyltransferase	S5WBE2	Pseudomonas_phage	4.9e-06	22.4
WP_014463234.1\|349614_350814_-	DUF87 domain-containing protein	W8CYG2	Bacillus_phage	2.6e-13	29.8
WP_014463235.1\|351068_352277_-	hypothetical protein	NA	NA	NA	NA
WP_158306709.1\|352472_352694_-	hypothetical protein	NA	NA	NA	NA
WP_014463237.1\|353229_354081_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_041694883.1\|354312_355188_+\|integrase	tyrosine-type recombinase/integrase	A0A142F1N9	Bacillus_phage	8.3e-17	24.7
WP_014463239.1\|355184_355931_+	hypothetical protein	NA	NA	NA	NA
WP_148260097.1\|356121_356718_+	hypothetical protein	NA	NA	NA	NA
WP_041694884.1\|356647_358513_+	hypothetical protein	NA	NA	NA	NA
WP_158306710.1\|358425_359559_+	hypothetical protein	NA	NA	NA	NA
WP_041694885.1\|359591_360404_+	hypothetical protein	NA	NA	NA	NA
WP_148260234.1\|360463_361660_-	DUF87 domain-containing protein	A0A0S2GLG9	Bacillus_phage	3.8e-12	28.1
WP_041695631.1\|362119_363319_-\|transposase	transposase	NA	NA	NA	NA
WP_041694887.1\|363616_365440_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_049784330.1\|366531_366864_+\|transposase	transposase	NA	NA	NA	NA
WP_049784400.1\|366917_367220_+	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	1.0e-14	41.0
WP_014463251.1\|367269_368895_+\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	3.4e-72	35.5
WP_014463254.1\|370232_370889_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_049784310.1\|370904_372494_+	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
WP_041694889.1\|372528_374688_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_193352813.1\|374734_375196_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_158306711.1\|375922_376318_-	hypothetical protein	NA	NA	NA	NA
WP_014463260.1\|376388_376649_-\|transposase	transposase	NA	NA	NA	NA
387128:387144	attR	NA	NA	NA	NA

DBSCAN-SWA_2

523605 : 532913

Prochlorococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041694927.1\|523605_524898_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.1e-22	36.2
WP_041694928.1\|524935_525655_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	E3SPA9	Prochlorococcus_phage	4.2e-43	41.9
WP_014463391.1\|525651_525912_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_014463392.1\|525908_526589_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_014463393.1\|526581_528816_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.7e-162	43.0
WP_014463394.1\|528836_530279_+	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	1.3e-54	31.1
WP_014463395.1\|530282_531308_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.5e-62	43.9
WP_014463396.1\|531344_532913_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	3.4e-77	50.8

DBSCAN-SWA_3

1051884 : 1062032

Leptospira_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_049784329.1\|1051884_1052745_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	9.9e-47	40.7
WP_014463251.1\|1053247_1054873_-\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	3.4e-72	35.5
WP_049784400.1\|1054922_1055225_-	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	1.0e-14	41.0
WP_049784330.1\|1055278_1055611_-\|transposase	transposase	NA	NA	NA	NA
WP_158306717.1\|1056183_1056474_+\|transposase	transposase	NA	NA	NA	NA
WP_014463898.1\|1056633_1058154_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_049784331.1\|1059642_1060410_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	2.2e-61	51.4
WP_041695058.1\|1060832_1062032_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_4

1094222 : 1149882

Leptospira_phage(16.67%)

transposase,integrase

attL 1086753:1086768|attR 1127532:1127547

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1086753:1086768	attL	NA	NA	NA	NA
WP_081462247.1\|1094222_1094468_-\|integrase	tyrosine-type recombinase/integrase	A0A0S2SXP1	Bacillus_phage	2.0e-13	50.7
WP_041695072.1\|1097944_1099285_+	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_049784332.1\|1099363_1100311_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_041695073.1\|1100303_1101131_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_014463950.1\|1101162_1104288_+	DUF4981 domain-containing protein	L0N6M2	Herpes_simplex_virus	8.8e-170	36.9
WP_049784330.1\|1104650_1104983_+\|transposase	transposase	NA	NA	NA	NA
WP_049784400.1\|1105036_1105339_+	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	1.0e-14	41.0
WP_014463251.1\|1105388_1107014_+\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	3.4e-72	35.5
WP_014463954.1\|1107561_1107849_-\|transposase	transposase	NA	NA	NA	NA
WP_014463956.1\|1108078_1109230_+	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_014463957.1\|1109245_1110055_+	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
WP_014463958.1\|1110073_1110826_+	glucose 1-dehydrogenase	Q06VL0	Trichoplusia_ni_ascovirus	1.9e-17	32.0
WP_014463959.1\|1110855_1112082_+	acyl--CoA ligase	NA	NA	NA	NA
WP_158306718.1\|1111970_1112561_+	AMP-binding protein	NA	NA	NA	NA
WP_148260128.1\|1112598_1113885_-	DUF2029 domain-containing protein	NA	NA	NA	NA
WP_014463962.1\|1114179_1115193_+	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	3.8e-29	31.2
WP_014463965.1\|1116913_1117480_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	2.5e-54	55.0
WP_014463966.1\|1117504_1119052_+	anthranilate synthase component I family protein	NA	NA	NA	NA
WP_014463967.1\|1119379_1119649_-	hypothetical protein	NA	NA	NA	NA
WP_014463968.1\|1119822_1120869_+	N-acetyl-gamma-glutamyl-phosphate reductase	NA	NA	NA	NA
WP_148260251.1\|1120881_1121667_+	acetylglutamate kinase	NA	NA	NA	NA
WP_014463970.1\|1121663_1122833_+	acetylornithine/succinylornithine family transaminase	A0A1V0SKB7	Klosneuvirus	3.0e-22	26.5
WP_014463971.1\|1122915_1123404_-	N-acetyltransferase	NA	NA	NA	NA
WP_041695076.1\|1128281_1129349_+	ornithine carbamoyltransferase	M1HWF9	Paramecium_bursaria_Chlorella_virus	7.2e-23	29.0
1127532:1127547	attR	NA	NA	NA	NA
WP_193352819.1\|1129345_1130611_+	argininosuccinate synthase	NA	NA	NA	NA
WP_014463976.1\|1130607_1131987_+	argininosuccinate lyase	NA	NA	NA	NA
WP_041695715.1\|1133719_1134955_+	aspartate kinase	NA	NA	NA	NA
WP_014463979.1\|1135136_1136726_+	phosphoglycerate dehydrogenase	A0A1V0SBV6	Catovirus	8.5e-52	34.9
WP_041695716.1\|1136786_1137863_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	1.3e-83	47.1
WP_014463981.1\|1137878_1139006_+	HAD family hydrolase	NA	NA	NA	NA
WP_014463112.1\|1141661_1143014_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_014463986.1\|1143390_1146903_+	DUF3883 domain-containing protein	A0A1B1IUI1	uncultured_Mediterranean_phage	8.7e-57	27.7
WP_014463988.1\|1148181_1149882_+\|transposase	IS1634 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

1354564 : 1419242

Bacillus_phage(14.29%)

coat,tRNA,integrase,protease,transposase

attL 1354525:1354541|attR 1423043:1423059

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1354525:1354541	attL	NA	NA	NA	NA
WP_014464189.1\|1354564_1355473_+\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA
WP_014464190.1\|1355477_1356455_+	bifunctional riboflavin kinase/FAD synthetase	A0A1V0SJE1	Klosneuvirus	1.3e-10	34.8
WP_041695127.1\|1356472_1356859_+	gamma-glutamylcyclotransferase	NA	NA	NA	NA
WP_008339940.1\|1357014_1357281_+	30S ribosomal protein S15	NA	NA	NA	NA
WP_014464192.1\|1357391_1359599_+	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
WP_041695128.1\|1359659_1360622_+	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_148260135.1\|1360672_1361938_+	insulinase family protein	G3MBJ8	Bacillus_virus	6.1e-45	28.3
WP_041695129.1\|1361952_1362402_+	dUTP diphosphatase	Q2NP83	Xanthomonas_phage	1.1e-28	50.4
WP_041695130.1\|1362543_1363455_+	dipicolinate synthase subunit DpsA	NA	NA	NA	NA
WP_014464197.1\|1363445_1364048_+	dipicolinate synthase subunit B	NA	NA	NA	NA
WP_014464198.1\|1364077_1365115_+	aspartate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_014464199.1\|1365134_1366352_+	aspartate kinase	NA	NA	NA	NA
WP_014464200.1\|1366367_1367258_+	4-hydroxy-tetrahydrodipicolinate synthase	NA	NA	NA	NA
WP_014464201.1\|1367254_1368520_+	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	2.5e-22	24.0
WP_014464202.1\|1368672_1370418_+	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_014464203.1\|1370425_1371316_+	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_014464204.1\|1371340_1372783_+	CoA-acylating methylmalonate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_014464205.1\|1372801_1373872_+	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_014464206.1\|1373908_1375555_+	acyl--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	1.3e-79	38.4
WP_014464207.1\|1375559_1376738_+	thiolase family protein	NA	NA	NA	NA
WP_014464208.1\|1376770_1377529_+	3-hydroxyacyl-CoA dehydrogenase	NA	NA	NA	NA
WP_014464209.1\|1377583_1378678_-	Glu/Leu/Phe/Val dehydrogenase	NA	NA	NA	NA
WP_014464211.1\|1379148_1380804_+	ribonuclease J	A0A0C5AJ83	Bacteriophage	2.5e-06	30.6
WP_014464212.1\|1380983_1381763_+\|protease	ATP-dependent Clp protease proteolytic subunit	NA	NA	NA	NA
WP_014464213.1\|1381762_1381966_+	YlzJ-like family protein	NA	NA	NA	NA
WP_014464214.1\|1382031_1384461_+	DNA translocase FtsK	A0A218M9A2	Mycobacterium_phage	1.7e-88	49.4
WP_014464215.1\|1384523_1385105_+	hypothetical protein	NA	NA	NA	NA
WP_014464216.1\|1385152_1385503_-	hypothetical protein	NA	NA	NA	NA
WP_148260136.1\|1385661_1386690_+	hypothetical protein	NA	NA	NA	NA
WP_012810807.1\|1386713_1387484_+	DUF3388 domain-containing protein	NA	NA	NA	NA
WP_041695131.1\|1387513_1388452_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014464219.1\|1388500_1388995_+	YajQ family cyclic di-GMP-binding protein	NA	NA	NA	NA
WP_041695740.1\|1389646_1390945_+	competence/damage-inducible protein A	B5TK85	Pseudomonas_phage	5.0e-18	40.0
WP_014464222.1\|1390949_1392530_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	8.4e-68	39.3
WP_014464223.1\|1392757_1393822_+	recombinase RecA	A0A0S2MVG1	Bacillus_phage	1.4e-127	70.6
WP_014464224.1\|1393784_1394486_+	regulatory protein RecX	NA	NA	NA	NA
WP_041695132.1\|1394617_1396165_+	ribonuclease Y	NA	NA	NA	NA
WP_014464226.1\|1396329_1396590_+	stage V sporulation protein S	J9PTX7	Bacillus_phage	2.5e-09	42.5
WP_041695741.1\|1396615_1397563_+	dipeptidase	NA	NA	NA	NA
WP_014464228.1\|1397876_1398413_+\|coat	outer spore coat protein CotE	NA	NA	NA	NA
WP_014464229.1\|1398475_1399552_+	YheC/YheD family protein	NA	NA	NA	NA
WP_014464230.1\|1399569_1400682_+	YheC/YheD family protein	NA	NA	NA	NA
WP_014464233.1\|1402198_1403320_+	YheC/YheD family protein	NA	NA	NA	NA
WP_008340032.1\|1403316_1403565_-	hypothetical protein	NA	NA	NA	NA
WP_014464235.1\|1403667_1405161_+\|tRNA	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	NA	NA	NA	NA
WP_014464236.1\|1405160_1405613_+	YlbF family regulator	NA	NA	NA	NA
WP_014464237.1\|1405625_1408229_+	DNA mismatch repair protein MutS	A0A1V0SDQ0	Indivirus	1.5e-34	27.3
WP_014464238.1\|1408228_1410115_+	DNA mismatch repair endonuclease MutL	A0A1B2LRQ5	Wolbachia_phage	3.6e-57	29.4
WP_041695133.1\|1410111_1410912_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_014464240.1\|1410908_1411910_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_014464241.1\|1411911_1412172_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_148260137.1\|1413254_1413776_+\|transposase	transposase	NA	NA	NA	NA
WP_081462253.1\|1413875_1414367_+\|transposase	transposase	NA	NA	NA	NA
WP_006446313.1\|1415732_1416548_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.3e-61	48.1
WP_014464251.1\|1418105_1418444_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_158306720.1\|1418738_1419242_-\|transposase	IS3 family transposase	NA	NA	NA	NA
1423043:1423059	attR	NA	NA	NA	NA

DBSCAN-SWA_6

1703924 : 1795827

Leptospira_phage(26.09%)

protease,holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_081462258.1\|1703924_1704023_-\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_014464555.1\|1704100_1704592_-	hypothetical protein	NA	NA	NA	NA
WP_014464556.1\|1704614_1705088_-	hypothetical protein	NA	NA	NA	NA
WP_041695221.1\|1705188_1706550_-	ParB N-terminal domain-containing protein	NA	NA	NA	NA
WP_014464560.1\|1711291_1712515_-	hypothetical protein	NA	NA	NA	NA
WP_014464561.1\|1712623_1713178_-	hypothetical protein	NA	NA	NA	NA
WP_014464564.1\|1715079_1715910_-	hypothetical protein	NA	NA	NA	NA
WP_014464565.1\|1715916_1717158_-	ParB/RepB/Spo0J family partition protein	NA	NA	NA	NA
WP_014464566.1\|1717382_1717766_-	gamma-glutamylcyclotransferase	H8ZM44	Pseudomonas_phage	1.6e-09	38.5
WP_193352800.1\|1717939_1718098_+	hypothetical protein	NA	NA	NA	NA
WP_014464567.1\|1718922_1719552_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_081462260.1\|1719590_1719884_-	helicase	NA	NA	NA	NA
WP_158306725.1\|1719870_1724259_-	DEAD/DEAH box helicase family protein	A0A1V0SHP4	Klosneuvirus	3.5e-39	27.6
WP_158306726.1\|1724520_1724811_+	hypothetical protein	NA	NA	NA	NA
WP_193352802.1\|1724855_1725143_-	hypothetical protein	NA	NA	NA	NA
WP_014464573.1\|1725199_1726039_+	Dam family site-specific DNA-(adenine-N6)-methyltransferase	A0A1S6L1V5	Vibrio_phage	1.2e-52	44.1
WP_014464574.1\|1726186_1727788_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_148260264.1\|1728095_1728980_-	hypothetical protein	A0A0K2CZE3	Paenibacillus_phage	2.3e-30	39.8
WP_158306727.1\|1729193_1729766_-\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_014464578.1\|1730394_1731201_-\|transposase	transposase	NA	NA	NA	NA
WP_081442619.1\|1731309_1731600_-	gamma-glutamylcyclotransferase	NA	NA	NA	NA
WP_014464579.1\|1731698_1731980_-	YolD-like family protein	NA	NA	NA	NA
WP_012810500.1\|1732753_1733134_+	winged helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	1.5e-10	35.2
WP_148260154.1\|1733218_1734082_+	cation transporter	NA	NA	NA	NA
WP_012810498.1\|1734097_1734751_+	cation transporter	NA	NA	NA	NA
WP_014464583.1\|1735177_1735576_-	VOC family protein	V5UQY3	Oenococcus_phage	2.9e-33	51.1
WP_014464585.1\|1736554_1737316_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.1e-38	37.6
WP_148260265.1\|1737315_1738737_-\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	1.5e-15	27.2
WP_081462263.1\|1739530_1740064_-	NUDIX domain-containing protein	A0A0B5CYJ3	Rhizoctonia_fumigata_mycovirus	2.4e-06	44.1
WP_081462264.1\|1742273_1743047_-	SDR family oxidoreductase	A0A0N9R355	Chrysochromulina_ericina_virus	1.2e-19	30.2
WP_014464591.1\|1743027_1744413_-	hypothetical protein	NA	NA	NA	NA
WP_158306728.1\|1744458_1745706_-	amino acid permease	NA	NA	NA	NA
WP_148260155.1\|1747579_1748653_-	hypothetical protein	NA	NA	NA	NA
WP_014464593.1\|1748961_1750395_-\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_158306729.1\|1750993_1751281_+	hypothetical protein	NA	NA	NA	NA
WP_148260084.1\|1751169_1751502_+	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_049784397.1\|1751555_1751858_+	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	1.0e-14	41.0
WP_014463046.1\|1751903_1753529_+\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	5.8e-72	38.0
WP_148260157.1\|1753793_1755377_-\|transposase	IS66 family transposase	S5VTP8	Leptospira_phage	9.4e-27	40.2
WP_014464597.1\|1755438_1755804_-	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	1.4e-21	43.4
WP_014464598.1\|1755797_1756157_-	IS66 family insertion sequence hypothetical protein	NA	NA	NA	NA
WP_041695229.1\|1756199_1756379_-\|transposase	transposase	NA	NA	NA	NA
WP_014464600.1\|1757007_1758684_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_158306730.1\|1758884_1759184_+\|transposase	transposase	NA	NA	NA	NA
WP_014464602.1\|1759536_1759791_-	hypothetical protein	NA	NA	NA	NA
WP_014464603.1\|1759812_1761042_-	FAD-dependent monooxygenase	NA	NA	NA	NA
WP_014464604.1\|1761073_1761559_-	DinB family protein	NA	NA	NA	NA
WP_014464605.1\|1761591_1762521_-	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_041695230.1\|1762543_1763629_-	cupin domain-containing protein	NA	NA	NA	NA
WP_041695787.1\|1763651_1764050_-	acyl-CoA thioesterase	NA	NA	NA	NA
WP_041695231.1\|1764073_1765345_-	MFS transporter	NA	NA	NA	NA
WP_049784350.1\|1765581_1767243_-	acyl--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	1.6e-37	28.0
WP_014464611.1\|1768461_1769238_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_148260158.1\|1772234_1773329_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	7.9e-49	38.4
WP_014463112.1\|1773466_1774819_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_148260157.1\|1775039_1776623_-\|transposase	IS66 family transposase	S5VTP8	Leptospira_phage	9.4e-27	40.2
WP_014464597.1\|1776684_1777050_-	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	1.4e-21	43.4
WP_014464598.1\|1777043_1777403_-	IS66 family insertion sequence hypothetical protein	NA	NA	NA	NA
WP_081462267.1\|1777445_1777739_-	hypothetical protein	NA	NA	NA	NA
WP_041695233.1\|1778007_1778547_-	LuxR family transcriptional regulator	NA	NA	NA	NA
WP_014464618.1\|1778587_1779469_-	hypothetical protein	NA	NA	NA	NA
WP_014464619.1\|1779509_1780139_-	hypothetical protein	NA	NA	NA	NA
WP_041695791.1\|1780211_1780934_-	DUF3820 family protein	A0A1C3S7F5	Escherichia_phage	1.6e-21	30.2
WP_041695793.1\|1781150_1781669_-	AAA family ATPase	NA	NA	NA	NA
WP_041695234.1\|1781665_1782064_-	RusA family crossover junction endodeoxyribonuclease	A0A139ZPD4	Marinitoga_camini_virus	6.7e-06	35.8
WP_014464623.1\|1782083_1782296_-	hypothetical protein	NA	NA	NA	NA
WP_041695235.1\|1782395_1782602_-	hypothetical protein	NA	NA	NA	NA
WP_041695236.1\|1782585_1782825_-	hypothetical protein	NA	NA	NA	NA
WP_041695237.1\|1782968_1783175_-	hypothetical protein	NA	NA	NA	NA
WP_014464626.1\|1783184_1783514_-	hypothetical protein	NA	NA	NA	NA
WP_014464627.1\|1783516_1783927_-	DUF669 domain-containing protein	NA	NA	NA	NA
WP_014464628.1\|1784034_1784385_-	hypothetical protein	NA	NA	NA	NA
WP_014464630.1\|1785053_1785326_-	hypothetical protein	NA	NA	NA	NA
WP_014464631.1\|1785322_1785538_-	hypothetical protein	NA	NA	NA	NA
WP_148260159.1\|1785801_1786056_-	hypothetical protein	NA	NA	NA	NA
WP_014464633.1\|1786080_1786278_-	hypothetical protein	NA	NA	NA	NA
WP_041695795.1\|1786268_1786766_-	hypothetical protein	NA	NA	NA	NA
WP_041695240.1\|1786991_1788104_-	DNA polymerase III subunit beta	R9TRR6	Rhizobium_phage	2.0e-23	26.9
WP_041695241.1\|1788091_1788394_-	hypothetical protein	NA	NA	NA	NA
WP_148260160.1\|1788405_1788804_-	DUF4406 domain-containing protein	G8I4J1	Mycobacterium_phage	1.3e-20	53.3
WP_014464639.1\|1788761_1788956_-	hypothetical protein	NA	NA	NA	NA
WP_041695242.1\|1789063_1789414_-	hypothetical protein	NA	NA	NA	NA
WP_014464641.1\|1789430_1789964_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_158306731.1\|1790257_1790431_-	hypothetical protein	NA	NA	NA	NA
WP_014464644.1\|1791052_1792870_-	DEAD/DEAH box helicase	Q6J7X8	Actinoplanes_phage	1.5e-49	35.7
WP_158306732.1\|1792976_1793594_-	hypothetical protein	NA	NA	NA	NA
WP_158306733.1\|1793740_1793914_-	hypothetical protein	NA	NA	NA	NA
WP_014464646.1\|1794390_1794798_+\|transposase	transposase	NA	NA	NA	NA
WP_014464647.1\|1794814_1795681_+\|transposase	transposase	NA	NA	NA	NA
WP_158306734.1\|1795578_1795827_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_7

1808460 : 1850207

Bacillus_phage(28.57%)

protease,transposase,tRNA,integrase

attL 1805598:1805611|attR 1814899:1814912

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1805598:1805611	attL	NA	NA	NA	NA
WP_014464666.1\|1808460_1809594_+\|integrase	site-specific integrase	A0A1B0T6A8	Bacillus_phage	6.2e-73	43.0
WP_041695246.1\|1810256_1811480_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	8.8e-150	67.3
WP_158306735.1\|1811573_1811876_-	hypothetical protein	NA	NA	NA	NA
WP_158306736.1\|1811880_1812219_-	hypothetical protein	NA	NA	NA	NA
WP_041695247.1\|1812215_1812689_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_148260166.1\|1813081_1814125_-	type II secretion system F family protein	NA	NA	NA	NA
WP_041695248.1\|1814108_1815065_-	Flp pilus assembly complex ATPase component TadA	NA	NA	NA	NA
1814899:1814912	attR	NA	NA	NA	NA
WP_041695249.1\|1815168_1815510_-	Mov34/MPN/PAD-1 family protein	NA	NA	NA	NA
WP_014464676.1\|1815547_1816828_-	GTPase ObgE	NA	NA	NA	NA
WP_041695250.1\|1816832_1817291_-	Spo0B domain-containing protein	NA	NA	NA	NA
WP_041695251.1\|1817366_1817672_-	50S ribosomal protein L27	NA	NA	NA	NA
WP_014464679.1\|1817730_1818051_-\|protease	ribosomal-processing cysteine protease Prp	NA	NA	NA	NA
WP_012811120.1\|1818047_1818362_-	50S ribosomal protein L21	NA	NA	NA	NA
WP_041695252.1\|1818468_1819377_-\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_041695253.1\|1819373_1820240_-	peptidoglycan DD-metalloendopeptidase family protein	NA	NA	NA	NA
WP_041695254.1\|1820303_1821098_-	septum site-determining protein MinD	NA	NA	NA	NA
WP_041695255.1\|1821103_1821796_-	septation ring formation regulator EzrA	NA	NA	NA	NA
WP_014464684.1\|1821887_1822409_-	rod shape-determining protein MreD	NA	NA	NA	NA
WP_041695256.1\|1822405_1823272_-	rod shape-determining protein MreC	NA	NA	NA	NA
WP_014464686.1\|1823295_1824330_-	rod shape-determining protein	NA	NA	NA	NA
WP_014464687.1\|1824346_1825048_-	DNA repair protein RadC	NA	NA	NA	NA
WP_041695257.1\|1825271_1826237_-	hypothetical protein	NA	NA	NA	NA
WP_041695258.1\|1826384_1828211_-	alkaline phosphatase family protein	NA	NA	NA	NA
WP_041695259.1\|1828407_1829397_-	DUF348 domain-containing protein	A0A217ER34	Bacillus_phage	2.6e-14	55.3
WP_041695260.1\|1829665_1831057_-	UDP-N-acetylmuramate--L-alanine ligase	NA	NA	NA	NA
WP_014464693.1\|1831072_1832371_-	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_193352832.1\|1832385_1835037_-\|tRNA	valine--tRNA ligase	A0A1V0SK04	Klosneuvirus	1.1e-168	41.7
WP_014464696.1\|1835310_1835847_-	hypothetical protein	NA	NA	NA	NA
WP_162470212.1\|1835916_1836210_-	hypothetical protein	NA	NA	NA	NA
WP_014464698.1\|1836223_1837597_-	hypothetical protein	NA	NA	NA	NA
WP_041695261.1\|1837710_1839018_-	glutamate-1-semialdehyde 2,1-aminomutase	NA	NA	NA	NA
WP_193352833.1\|1839030_1840011_-	porphobilinogen synthase	NA	NA	NA	NA
WP_014464701.1\|1840016_1840760_-	uroporphyrinogen-III synthase	NA	NA	NA	NA
WP_041695262.1\|1840770_1841679_-	hydroxymethylbilane synthase	NA	NA	NA	NA
WP_041695263.1\|1841696_1842494_-	cytochrome c biogenesis protein CcsA	NA	NA	NA	NA
WP_041695264.1\|1842502_1843858_-\|tRNA	glutamyl-tRNA reductase	NA	NA	NA	NA
WP_014464705.1\|1843984_1844647_-	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_014464706.1\|1844643_1847079_-	endopeptidase La	A0A0R6PGP8	Moraxella_phage	4.8e-163	41.4
WP_014464707.1\|1847160_1848837_-\|protease	ATP-dependent protease LonB	A0A076FMQ5	Aureococcus_anophage	2.6e-11	31.4
WP_008340896.1\|1848935_1850207_-\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	7.3e-155	67.6

DBSCAN-SWA_8

2374423 : 2380699

Clostridium_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041695400.1\|2374423_2374762_+	hypothetical protein	B6SBX1	Clostridium_virus	4.8e-05	50.0
WP_014465241.1\|2375150_2375333_-	hypothetical protein	NA	NA	NA	NA
WP_041695401.1\|2375353_2375704_+	hypothetical protein	NA	NA	NA	NA
WP_081462280.1\|2375730_2376081_-	hypothetical protein	NA	NA	NA	NA
WP_081462281.1\|2376077_2376308_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014465245.1\|2376399_2376648_+	helix-turn-helix transcriptional regulator	A0A1L2JY18	Aeribacillus_phage	1.6e-10	43.5
WP_148260199.1\|2376652_2376862_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_041695892.1\|2376977_2377205_+	helix-turn-helix transcriptional regulator	S5MNZ4	Brevibacillus_phage	1.1e-05	43.5
WP_041695894.1\|2377207_2377441_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_158306749.1\|2377839_2378013_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_081462282.1\|2378192_2378729_+	helix-turn-helix domain-containing protein	A0A0A7RUJ5	Clostridium_phage	3.3e-08	51.5
WP_081462283.1\|2378733_2379210_+	ImmA/IrrE family metallo-endopeptidase	B6SBW7	Clostridium_virus	4.0e-05	34.8
WP_041695403.1\|2379163_2380699_+	recombinase family protein	A0A0K2CNN5	Brevibacillus_phage	1.3e-94	39.2

DBSCAN-SWA_9

2809794 : 2843970

Leptospira_phage(40.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014465667.1\|2809794_2810382_+\|transposase	IS607 family transposase	F9VHY9	Thermus_phage	1.2e-32	43.4
WP_014465668.1\|2810353_2811505_+\|transposase	transposase	A0A7P9	Microcystis_virus	1.4e-64	41.4
WP_041695502.1\|2812637_2814359_-	phosphomethylpyrimidine synthase ThiC	NA	NA	NA	NA
WP_014465671.1\|2814765_2816238_-	cytosine permease	NA	NA	NA	NA
WP_041695503.1\|2816581_2817373_-	membrane protein	NA	NA	NA	NA
WP_014465673.1\|2817450_2818263_-	Dam family site-specific DNA-(adenine-N6)-methyltransferase	A0A1S6L1V5	Vibrio_phage	5.4e-71	50.2
WP_014465674.1\|2818412_2818616_-	heavy-metal-associated domain-containing protein	A0A218MNH0	uncultured_virus	7.3e-09	50.8
WP_193352837.1\|2818656_2818917_-	metal-sensitive transcriptional regulator	NA	NA	NA	NA
WP_041695946.1\|2820595_2821147_+	alkaline shock response membrane anchor protein AmaP	NA	NA	NA	NA
WP_041695505.1\|2821139_2821394_+	DUF2273 domain-containing protein	NA	NA	NA	NA
WP_014465681.1\|2821464_2821839_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_014465682.1\|2822028_2822523_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_014465683.1\|2822519_2823701_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_041695947.1\|2823791_2825057_-	MFS transporter	NA	NA	NA	NA
WP_014465685.1\|2825173_2826217_-	NAD(P)-dependent alcohol dehydrogenase	A0A2K9L339	Tupanvirus	7.5e-73	43.7
WP_014465686.1\|2826421_2827039_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_049784387.1\|2827106_2828480_-	aspartate aminotransferase family protein	NA	NA	NA	NA
WP_014465690.1\|2831276_2831642_-	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	9.4e-23	45.1
WP_049784300.1\|2831635_2832016_-	IS66 family insertion sequence hypothetical protein	NA	NA	NA	NA
WP_014465691.1\|2832048_2833209_-	NAD-dependent dihydropyrimidine dehydrogenase subunit PreA	NA	NA	NA	NA
WP_081462293.1\|2833261_2833633_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_049784330.1\|2833737_2834070_+\|transposase	transposase	NA	NA	NA	NA
WP_049784400.1\|2834123_2834426_+	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	1.0e-14	41.0
WP_014465693.1\|2834475_2836101_+\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	9.8e-72	35.3
WP_158306751.1\|2838056_2839229_+	MFS transporter	NA	NA	NA	NA
WP_049784330.1\|2840147_2840480_+\|transposase	transposase	NA	NA	NA	NA
WP_049784400.1\|2840533_2840836_+	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	1.0e-14	41.0
WP_014465698.1\|2842752_2843970_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	4.9e-100	51.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_017167

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection