CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015424	Aeromonas veronii B565, complete sequence	5 crisprs	DEDDh,csa3,DinG,cas3,WYL,RT	0	0	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_015424_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015424_1

666006-666111

Orphan

Consensus_repeat	Method
ACTAAACGCCAAGGTTTGATCCGAATGAAATCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015424_1

>merge|NC_015424|1|666006-666111|CRISPRCasFinder
ACTAAACGCCAAGGTTTGATCCGAATGAAATCTGCATATGCGAGCGACGATGGCGCTGGCCGTTTTATCTGTACTAAACGCTAAGGTTTGATCCGAATGAAATCTG

>NC_015424|1|1|666006-666111|CRISPRCasFinder
ACTAAACGCCAAGGTTTGATCCGAATGAAATCTG	CATATGCGAGCGACGATGGCGCTGGCCGTTTTATCTGT
ACTAAACGCTAAGGTTTGATCCGAATGAAATCTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015424.1\|WP_005354753.1\|669295_670015_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270422
NC_015424.1\|WP_005354743.1\|675469_676093_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NC_015424.1\|WP_005304871.1\|676404_676881_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_015424.1\|WP_005304908.1\|665418_665943_+\|peptidoglycan-associated-lipoprotein-Pal	unknown	unknown	gnl\|CDD\|182744
NC_015424.1\|WP_005354764.1\|661276_661684_+\|tol-pal-system-associated-acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|274304
NC_015424.1\|WP_005354746.1\|672589_673153_+\|DUF2799-domain-containing-protein	unknown	unknown	gnl\|CDD\|378521
NC_015424.1\|WP_005304933.1\|660756_660873_+\|cytochrome-bd-I-oxidase-subunit-CydX	unknown	unknown	gnl\|CDD\|227227
NC_015424.1\|WP_005354757.1\|662362_662809_+\|protein-TolR	unknown	unknown	gnl\|CDD\|274306
NC_015424.1\|WP_005354745.1\|673204_674023_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|182523
NC_015424.1\|WP_005335741.1\|659605_660742_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|184965
NC_015424.1\|WP_013723471.1\|662814_663948_+\|cell-envelope-integrity-protein-TolA	unknown	unknown	gnl\|CDD\|368950
NC_015424.1\|WP_005354744.1\|674133_675363_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_015424.1\|WP_005354742.1\|677016_677334_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225653
NC_015424.1\|WP_005335728.1\|664043_665369_+\|Tol-Pal-system-protein-TolB	unknown	unknown	gnl\|CDD\|235312
NC_015424.1\|WP_005354750.1\|670018_671332_-\|sodium-dependent-transporter	unknown	unknown	gnl\|CDD\|271367
NC_015424.1\|WP_005335740.1\|660925_661171_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370577
NC_015424.1\|WP_005354748.1\|671543_672383_-\|isopenicillin-N-synthase-family-oxygenase	unknown	unknown	gnl\|CDD\|226022
NC_015424.1\|WP_005354754.1\|667549_668863_-\|sodium-dependent-transporter	unknown	unknown	gnl\|CDD\|271367
NC_015424.1\|WP_005335735.1\|661673_662363_+\|protein-TolQ	unknown	unknown	gnl\|CDD\|131843
NC_015424.1\|WP_005335743.1\|658037_659594_+\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|185052

Protein	Function_ID	Function_description	E-value
NC_015424.1\|WP_005354753.1\|669295_670015_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270422	cd13704, PBP2_HisK, The periplasmic sensor domain of histidine kinase receptors; the type 2 periplasmic binding fold protein. This subfamily includes the periplasmic sensor domain of the histidine kinase receptors (HisK) which are elements of the two-component signal transduction systems commonly found in bacteria and lower eukaryotes. Typically, the two-component system consists of a membrane-spanning histidine kinase sensor and a cytoplasmic response regulator. The two-component systems serve as a stimulus-response coupling mechanism to enable microorganisms to sense and respond to changes in environmental conditions. Extracellular stimuli such as small molecule ligands and ions are detected by the N-terminal periplasmic sensing domain of the sensor kinase receptor, which regulate the catalytic activity of the cytoplasmic kinase domain and promote ATP-dependent autophosphorylation of a conserved histidine residue. The phosphate is then transferred to a conserved aspartate in the response regulator through a phospho-transfer mechanism, and the activity of the response regulator is in turn regulated. The sensor domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space through their function as an initial high-affinity binding component. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	7.13228e-14
NC_015424.1\|WP_005354743.1\|675469_676093_+\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	1.9677e-59
NC_015424.1\|WP_005304871.1\|676404_676881_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	3.22775e-48
NC_015424.1\|WP_005304908.1\|665418_665943_+\|peptidoglycan-associated-lipoprotein-Pal	gnl\|CDD\|182744	PRK10802, PRK10802, peptidoglycan-associated lipoprotein Pal.	3.5678e-77
NC_015424.1\|WP_005354764.1\|661276_661684_+\|tol-pal-system-associated-acyl-CoA-thioesterase	gnl\|CDD\|274304	TIGR02799, Acyl-CoA_thioesterase_YbgC, tol-pal system-associated acyl-CoA thioesterase. The tol-pal system consists of five critical genes. Inner membrane proteins TolQ and TolR convert protomotive force to energy that is transduced through TolA to an outer membrane complex of TolB and Pal. The system is known to be required to maintain outer membrane integrity. In a system with several homologous parts, ExbB and ExbD transduces energy through TonB to a variety of outer membrane proteins, many of which are siderophore receptors. The tol-pal system therefore may also be involved in transport. This family consists of a protein nearly always found in operons with the genes of the tol-pal system. The significance of this thioesterase to the tol-pal system is unclear, but either of two observations may be relevant. First, Pal, or peptidoglycan-associated lipoprotein, has a conserved N-terminal cleavage and acylation that makes it a lipoprotein. Second, the tol-pal system is implicated not only in the import of certain organics but also in the maintenance of outer membrane integrity (by an unknown mechanism).	1.15341e-54
NC_015424.1\|WP_005354746.1\|672589_673153_+\|DUF2799-domain-containing-protein	gnl\|CDD\|378521	pfam10973, DUF2799, Protein of unknown function (DUF2799). Some members in this family of proteins are annotated as yfiL which has no known function.	2.6913e-28
NC_015424.1\|WP_005304933.1\|660756_660873_+\|cytochrome-bd-I-oxidase-subunit-CydX	gnl\|CDD\|227227	COG4890, COG4890, Predicted outer membrane lipoprotein [Function unknown].	9.94001e-13
NC_015424.1\|WP_005354757.1\|662362_662809_+\|protein-TolR	gnl\|CDD\|274306	TIGR02801, Protein_TolR, TolR protein. The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	8.34399e-42
NC_015424.1\|WP_005354745.1\|673204_674023_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|182523	PRK10530, PRK10530, pyridoxal phosphate (PLP) phosphatase; Provisional.	1.28508e-80
NC_015424.1\|WP_005335741.1\|659605_660742_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|184965	PRK15003, PRK15003, cytochrome d ubiquinol oxidase subunit II.	7.4003e-160
NC_015424.1\|WP_013723471.1\|662814_663948_+\|cell-envelope-integrity-protein-TolA	gnl\|CDD\|368950	pfam06519, TolA, TolA C-terminal. This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.	1.87806e-20
NC_015424.1\|WP_005354744.1\|674133_675363_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.34299e-44
NC_015424.1\|WP_005354742.1\|677016_677334_-\|hypothetical-protein	gnl\|CDD\|225653	COG3111, COG3111, Periplasmic protein with OB-fold [Function unknown].	0.00134126
NC_015424.1\|WP_005335728.1\|664043_665369_+\|Tol-Pal-system-protein-TolB	gnl\|CDD\|235312	PRK04792, tolB, Tol-Pal system protein TolB.	0
NC_015424.1\|WP_005354750.1\|670018_671332_-\|sodium-dependent-transporter	gnl\|CDD\|271367	cd10336, SLC6sbd_Tyt1-Like, solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain. SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.	6.33016e-164
NC_015424.1\|WP_005335740.1\|660925_661171_+\|hypothetical-protein	gnl\|CDD\|370577	pfam09600, Cyd_oper_YbgE, Cyd operon protein YbgE (Cyd_oper_YbgE). This entry describes a small protein of unknown function, about 100 amino acids in length, essentially always found in an operon with CydAB, subunits of the cytochrome d terminal oxidase. It appears to be an integral membrane protein. It is found so far only in the Proteobacteria.	1.50037e-14
NC_015424.1\|WP_005354748.1\|671543_672383_-\|isopenicillin-N-synthase-family-oxygenase	gnl\|CDD\|226022	COG3491, PcbC, Isopenicillin N synthase and related dioxygenases [General function prediction only].	3.64873e-39
NC_015424.1\|WP_005354754.1\|667549_668863_-\|sodium-dependent-transporter	gnl\|CDD\|271367	cd10336, SLC6sbd_Tyt1-Like, solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain. SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.	9.08718e-165
NC_015424.1\|WP_005335735.1\|661673_662363_+\|protein-TolQ	gnl\|CDD\|131843	TIGR02796, Protein_TolQ, TolQ protein. TolQ is one of the essential components of the Tol-Pal system. Together with TolR, it harnesses protonmotive force to energize TolA, which spans the periplasm to reach the complex of TolB and Pal at the outer member. The tol-pal system proves to be important for maintaining outer membrane integrity. Gene pairs similar to the TolQ and TolR gene pair often number several per genome, but this model describes specificially TolQ per se, as found in tol-pal operons. A close homolog, excluded from this model, is ExbB of the ExbB/ExbD/TonB protein complex, which powers transport of siderophores and vitamin B12 across the bacterial outer membrane. The Tol-Pal system is exploited by colicin and filamentous phage DNA to enter the cell. It is also implicated in pathogenesis in several bacterial species [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	3.85704e-106
NC_015424.1\|WP_005335743.1\|658037_659594_+\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|185052	PRK15097, PRK15097, cytochrome bd-I ubiquinol oxidase subunit CydA.	0

>NC_015424.1|WP_005304908.1|665418_665943_+|peptidoglycan-associated-lipoprotein-Pal
MQLNKLLKGLAIALPLFTLAACSSSSDSDAAGAESGMTDGMGGVQTGGANGMLSPEEQMRQKFEALQRDNVIYFPFDGYDIQGQYADLLDAHASYLRERPSVKVLIEGHADERGTPEYNIALGERRAKAVAKYLQTLGVQAEQLSIVSYGEEKPLDMSHTEDAFAKNRRAVLVY
>NC_015424.1|WP_005335728.1|664043_665369_+|Tol-Pal-system-protein-TolB
MIRKVFFALVGCLLLGQSAQAALDIVITGGIDSARPIAVAPFKWEGNGQLPQDIAEVVSNDLMRSGKFKPLARGQMPQTPSSSSEINFAPWASQGVEAVVVGSISAVGDGTYKVNFELVDVLKGQLAKAQGGESNGYILDSRMATIPGAQMRQFAHRISDIVYERLTGERGAFLTRLAYVSVQQGTQFPYQLRISDYDGYNEKTLLRSREPLMSPAWSPDGSKLAYVSFENQKSEIYVQDIYTQQRSLITSFRGINGAPEWSPDGRRLAIVLSKDGSPNLYVVDVASKQLTRVTTSRVIDTEPSWMPDGQNLLFTSERGGKPQIYSVNLATGMTRRMTWEGESNQGASITPDGKIMVMVTRVQGQYRIARQDMENNALLVLTQSALDESPSVAPNGSMIIYATIYQGRKSLALVSTDGRFKAVLPTSSGEIRAPAWSPFLN
>NC_015424.1|WP_013723471.1|662814_663948_+|cell-envelope-integrity-protein-TolA
MDVKRGISGYLIASFLLHLIIGIILFVGLDFSKPKRPESKGQIVNAVMLDENFLNEQAKQIQQQKSQPKPQKVEKEKDKEDTDLAKRELAQKQEQLRIAETKRKQAEEATRKAEAEKQKKVAEQKQAEEKAQKAEEARKLEEQKAKKAEAERKAAEAESKALALKKKKEQEKKEAEEKAKAAEAKAKKAEADKKAKAEAEKKAKAEAEKKAKAEAEKKAKEEAEKKAKADAEKKAKAEAEKQAKIAAERKRKAAEQAKLQKEMEEMMQQQLSAEANARSQAASAAAQGEVDKYAALIKATVERYMILDPTMRGKTCTIGVRLASSGFVISVDNGQGDPAVCRSGKAAVLKANQLPVPKDPAAFEMLKEFNLKLEPSI
>NC_015424.1|WP_005354757.1|662362_662809_+|protein-TolR
MQTYQRIRRKKVAEINVVPYIDVMLVLLIIFMAVTPVITQGVKVDLPQAESEQLPEDAKPPFIVSVNTEGEYVIKAGEADDEPVPSGTPEAMQQYITEKAMGYLAINQNAPVVVAGDKAVRYEEVILLMVALKKAGVPQVGLMTDPVN
>NC_015424.1|WP_005335735.1|661673_662363_+|protein-TolQ
MHAEISFIGLFWQASLLVKLVMMTLMSMSIVSWALIIQRSKAIKAANLASEQFEDRFWSGVDLNRLYQESSSRRDDIEGMEDIFYSGFKEYARLLKAGARGQDAVMDGTYRAMRVSLSRAVDDLESNLPVLATIGSISPYIGLFGTVWGIMNAFIALGQVQQATLQMVAPGIAEALIATAMGLFAAIPAVIFYNRFSNKVERLENAYANFMDEFTTILNRQIAQQQGDQ
>NC_015424.1|WP_005354764.1|661276_661684_+|tol-pal-system-associated-acyl-CoA-thioesterase
MGEVFEFPVRVYYEDTDAGGIVYNANYLKFMERARTEFLRAKGVEQDVWLKEGYAFVVSRTEIDFRSAARFNELLNVLTQVIEVKRASLRFSQQILAADGRLITQAMVQIACVSHPQMKPVAIPEKIKGVLLSAR
>NC_015424.1|WP_005335740.1|660925_661171_+|hypothetical-protein
MLLAAALLAVAILQAPNLIAANTSEHGLWLAPWLMWAVCCGVLNGLGFHLKSLPGRVLFNPWLAWPSLLYGLWLTHSYFLS
>NC_015424.1|WP_005304933.1|660756_660873_+|cytochrome-bd-I-oxidase-subunit-CydX
MWYFTWILGLLLACAFGIINALWLEHTENMDRQIDENK
>NC_015424.1|WP_005335741.1|659605_660742_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MFDYETLRVIWWALVGVLLIGFAITDGFDMGVGALLPFVGKKDVERRVMLNTMGPHWEGNQVWLVTAGGALFAAWPMVYAATFSGFYIAMILTLMALFLRPVGFKYRSLRADAKWRSNWDWALFAGSAVPPIVFGVAFGNLLQGVPFEFNQFMMLTYHGNFFGLLNPFGILAGLVSLFMLLTQGATWLMMKTDGEVLARSRTAAMICSLLTLVLFAAAGWWVSGMEGYVIVKAAATDAVSNPMNKEVVLQAGAWMNNYTLYPWMVAAPVLGLAMSLLTALFARMNIGWLAFTSSSLAIAGVILTAGFSMFPFVMPSSLEPSLSLTMWDATASFNTLQVMTVAAAIFVPIVLGYTIWTYIKMFGRVTNKHIEDNQQSLY
>NC_015424.1|WP_005335743.1|658037_659594_+|cytochrome-ubiquinol-oxidase-subunit-I
MIAEHVVDLSRFQFAATALYHFLFVPLTLGMAFLLAIMESVYVMTNNTIYRDMTKFWGKLFGINFALGVTTGLAMEFQFGTNWAYYSHYVGDIFGAPLAIEGLMAFFLESTFVGMFFFGWDRLSKHQHLAATWLMALGTNLSALWILVANGWMQNPVGAEFNFESMRMEMMSFADVVLNPVAQVKFVHTVAAGYTCGAMFVLGISSYYLLKNRDVAFARRSFAIAAAFGMASIVSVLILGDESGYETGEVQKVKLAAIEAEWETEPAPAAFTLFGIPNQEEMRTDYAIKIPYALGIIATRSLDGQVTGLKDLKSEHELRVRNGMTAYDLLTKLQSGDKSDETRARFDEVKQDLGYGLLLKRYTSNVTDATDEQIKAAVDDSIPQVLPLFFAFRIMVAVGMLMLVLIGMAFYDSARHQIGKRKWLLKGLLWGIPLPWIAIEAGWFVAEYGRQPWTIAEVLPTSLSASNLPAAEIWFSLIGICLFYTVLLVIEMYLMFKYARLGPSSLKTGKYHFEQIKA
>NC_015424.1|WP_005354754.1|667549_668863_-|sodium-dependent-transporter
MSQVQWSSRLGHVLAAAGTAIGLGAIWKFPYVTATNGGGAFLLVFLLFSFTLGVAVQVGETLLGSHSQRGVLGAFRKLVGPNWRWMGYMGIACGFFIYSFYSVVGGWTVGYAALAMAGKLNLSEGSALTALFNGYVSNPWWPVLTHLIFAGLTWWFVQGGIQKGVERALRWMMPALFIMMLLLVGVGLSMPGSMAGVRQLLLPDFSMLTGQSVLDALGLAFFSLSIGLGVHTTYGAYLPNSEGVLRSGVWVVTLASLISVLAGLMIFPALASTGIDPTAGPGLTFMTMPAVFSHLPLGQGLGVVFFLLLLVAALSSSISMLEHLVRFTTEEWGWSRRGACRVLTLLIMASGIPVSLSFGPWSDLTLFGKTIFELLDYLTSNLMMPLFGLVLTLLLGWRLGDAILPVGLSPALRLALLWCWRVVAPLLISGILIRGIM
>NC_015424.1|WP_005354753.1|669295_670015_+|transporter-substrate-binding-domain-containing-protein
MRWMVLPWLLISLSVSAQPGLTLLSHDLPPFTEYRDGKLDGFAIRLIDEVQEELGTRYPVRIYPLKRALALARVEPGYGLFVVQRLPERESHFKWVGPLFINRVFIYQAPDSRHPLTSLAQLRDLPRVGVVLGNADDVRLTHEGYTNLVRYKTVGEAIERLMLGKIDALPMAELVMEATLDKMGLSRRSIVSSGVLLHQAGLYIVFSKGTDDAEITRWQHALDAVRVAQGRADGPTREE
>NC_015424.1|WP_005354750.1|670018_671332_-|sodium-dependent-transporter
MKQSQWSSRLGYILAAAGSAVGIGAIWKFPYVTAVNGGGAFLLVFLLFSFTLGVAVLMGETLLGSMSRRGVVGAFSDLLGKQWRWVGVMGVISTLLIYCFYSVVGGWTLGYTGMAISGQLNHGDAAALTARFNDYVSGDVWPILTHLLFAAFTWMVVQGGIQKGVERTLRWMMPALFLMILMLVAFGLTLPNAMAGVRHFLMPDFSKLGMSGVLDAMGLAFFSLSIGLGIHTTYGAYLPTSEGVGRSSLWVVLLASMVAVLAGLMIFPVLASTGIDPASGPGLTFMTMPAVFQLLPFGQVLEVIFFALLVFAALSSAISLLEHLQCFLCETWGWSRRMACSAITGFVMVSGVPVSLSFGPLQHATLFGKTIFELLDFVTSNLMMPLFGLMLTLLLGWKLGRKALPQGIASHWHHLLMNCWRWVAPLLIGGILIRGLV
>NC_015424.1|WP_005354748.1|671543_672383_-|isopenicillin-N-synthase-family-oxygenase
MKVLTVDYRSPDAAQRFTESLRTTGFGVLTNHPIPKELVQSIYDNWYRFFMSEQKQDFLFNRETQDGYFPPSVSEVAKGHSQKDIKEYFHIYPWGQMPEELKEQAMEYYRLANGLAAELLGWVEQYTPADIDAHYSCPLSSMIEESQKTLLRVLHYPPFDGTEEPGAIRAAAHEDINLLTILPAANEPGLQVKGSDGEWMDVPCDFGTLIINIGDMLQEASRGYYPSTTHRVINPTDGSAAKSRISLPLFLHPRPDVVLSERHTAHSYLMERLRELGVI
>NC_015424.1|WP_005354746.1|672589_673153_+|DUF2799-domain-containing-protein
MSPKILLLTLPVLLAGCSALSEDECRTMSWYNLGYQDGSEGKTRQASRDYVSSCSEYGLKVDEAEWKRGYDKGLELYCIPELAYSKGKEGQAYLGVCPNDARFLKQYQRGYEEYKLAARMREISDELERTERDIDTLERSIRNETNTEQRDYYRAKRDRAIRHYESLRREYNRLRYPDRVIQFSFGG
>NC_015424.1|WP_005354745.1|673204_674023_-|Cof-type-HAD-IIB-family-hydrolase
MSEYKAIALDMDGTLLTRDHKISSATRAALAQARAHGIKVLLVTGRHYMTARPFHHELALDTPLICSNGAYLYDPVQNGILSGDPLAAAPLTELLAAVEAQQMGALFHLSEGIGYIGCEEHVTRIRHWSANQPDHLKIAIHPVEELAGWLDNPVWKLELFNQDPARLHTFMGEVVEQMPFTRDWAAPYAVELVQPGCSKGNRLAQWAASEGIAMEQVVAFGDNNNDISMFEQVGLAVAMGNAAPQIQSHAHRVTADHNEDGIALALQRWVLP
>NC_015424.1|WP_005354744.1|674133_675363_-|MFS-transporter
MEKHEHKNPLWVLVMTVTLAVAGFSLPSPVLAPLLLDPAQGMLTPDASDWSRKVWLGVIMGLYPLFQLVGSPWLGRLSDRYGRKPLLLLSLAGVLAGYALMALGIAWRSLPLLLLSRIVEGLCNGNIAIVQAMAADLAGKEHKARSFAWINIGMNLGWVVGPMIGGYAAVISGDYSLAAWLAVGMTLLNLLLVYWLIPYRPPVAATRQTATLSSRQLLLQPALLPYFALTLISYGAVQLYFTYFNIWLVERLAWDPAQLAQAAVLVSLPMMAGSWLGSRIARHWRGSSLGIVGHLVMATGMLLFILPVHWWGLALTFVPAGIGMSLGELATSVAISNRSHPEQQGQAMGLYRALAVGSEILAVLLGSLVLLAGTEWPFYLATLCSLASAAGFYLLRRRADRRQQLASCT
>NC_015424.1|WP_005354743.1|675469_676093_+|transcriptional-regulator
MNASTDKILFLLKSHGPQSAAALGEQLQMTSMGARQHLLALEQEGWVTFSDEARGRGRPVRLWQLTEQAWQRFPDSHSDLTVQLIDNVRELFGEEGMEGLIQQRELQMLARYQEALGSHGLSGRLAALKELRSREGYMAEIRREEDGSWLLWESHCPICAAARTCRGFCRSELALFRQLLAPATVEREQYLLEGAHRCLYRITPPAL
>NC_015424.1|WP_005304871.1|676404_676881_+|Lrp/AsnC-family-transcriptional-regulator
MLKLDRIDRHILELMQENGRISNLELAELVGLSPSPCSRRVKALEDAGLIDTHVTLLNARQLGLTLTAYIHISMDRHTPERFENFDRAISELPEVLECDLITGNDADYQLKVVVRDMEHYQHFLLDKLTHIPGVTGVRSSFVLRRIKHKTALPLNHLG
>NC_015424.1|WP_005354742.1|677016_677334_-|hypothetical-protein
MQTSIVGLSILWGLASFGVQGDFIESRDSVAPSWQAESRVEMEGYLIESLGEDRWLFDNGSESLLVSLPEGQWVPTGERLRVSGEPQQEQSGWLLQVEDISQVSA

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Crispr_ID: NC_015424_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015424_2

723523-723650

Orphan

Consensus_repeat	Method
CGGGATCAATTGTCAGCACGGTTTTTCATTTGGTCAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015424_2

>merge|NC_015424|2|723523-723650|CRISPRCasFinder
CGGGATCAATTGTCAGCACGGTTTTTCATTTGGTCAGGCCTGAGCTATGTGCAGATTGACCGCTATTTTCGCTGGCAGACGGTTTCATGCGGGATCAATTGTCAGCACGGTTTTTCATTTGGTTAGGC

>NC_015424|2|2|723523-723650|CRISPRCasFinder
CGGGATCAATTGTCAGCACGGTTTTTCATTTGGTCAGGC	CTGAGCTATGTGCAGATTGACCGCTATTTTCGCTGGCAGACGGTTTCATG
CGGGATCAATTGTCAGCACGGTTTTTCATTTGGTTAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015424.1\|WP_005354651.1\|728062_729430_+\|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl\|CDD\|224736
NC_015424.1\|WP_005354659.1\|725178_725688_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NC_015424.1\|WP_005335640.1\|725684_726479_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723
NC_015424.1\|WP_005354670.1\|715553_717872_-\|penicillin-binding-protein-1B	unknown	unknown	gnl\|CDD\|273952
NC_015424.1\|WP_005354643.1\|730587_730995_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341115
NC_015424.1\|WP_005354662.1\|722534_723443_+\|tRNA-glutamyl-Q(34)-synthetase-GluQRS	unknown	unknown	gnl\|CDD\|274810
NC_015424.1\|WP_013723480.1\|729513_730041_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NC_015424.1\|WP_005354639.1\|731240_733343_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182330
NC_015424.1\|WP_005335639.1\|726680_727538_+\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|234741
NC_015424.1\|WP_005354675.1\|714311_714698_+\|multidrug-transporter	unknown	unknown	gnl\|CDD\|182471
NC_015424.1\|WP_005335642.1\|723700_725167_+\|polynucleotide-adenylyltransferase-PcnB	unknown	unknown	gnl\|CDD\|236939
NC_015424.1\|WP_005354666.1\|720571_721114_+\|RNA-2',3'-cyclic-phosphodiesterase	unknown	unknown	gnl\|CDD\|274058
NC_015424.1\|WP_005354664.1\|721110_721854_+\|DNA/RNA-nuclease-SfsA	unknown	unknown	gnl\|CDD\|234733
NC_015424.1\|WP_005354668.1\|717945_720393_-\|ATP-dependent-helicase-HrpB	unknown	unknown	gnl\|CDD\|236950
NC_015424.1\|WP_005354654.1\|727562_727913_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NC_015424.1\|WP_005354646.1\|730045_730465_-\|hypothetical-protein	unknown	unknown	unknown
NC_015424.1\|WP_005335644.1\|721973_722423_+\|RNA-polymerase-binding-protein-DksA	unknown	unknown	gnl\|CDD\|182722
NC_015424.1\|WP_005354677.1\|713271_714153_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_015424.1\|WP_005335659.1\|714694_715015_+\|multidrug-transporter	unknown	unknown	gnl\|CDD\|182618
NC_015424.1\|WP_005354672.1\|715093_715495_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319940

Protein	Function_ID	Function_description	E-value
NC_015424.1\|WP_005354651.1\|728062_729430_+\|cation:dicarboxylase-symporter-family-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	1.83307e-164
NC_015424.1\|WP_005354659.1\|725178_725688_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	1.79296e-66
NC_015424.1\|WP_005335640.1\|725684_726479_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	8.96019e-162
NC_015424.1\|WP_005354670.1\|715553_717872_-\|penicillin-binding-protein-1B	gnl\|CDD\|273952	TIGR02071, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NC_015424.1\|WP_005354643.1\|730587_730995_-\|hypothetical-protein	gnl\|CDD\|341115	cd17032, T3SC_IA_SycT-like, Class IA type III secretion system chaperone protein, similar to Yersinia enterocolitica SycT. This family includes type III secretion system (T3SS) chaperone proteins similar to Yersinia enterocolitica SycT and similar proteins. In Y. enterocolitica, a food-borne pathogen causing gastroenteritis and mesenteric lymphadenitis, chaperone SycT promotes translocation of effector YopT (Yersinia outer protein T), a cysteine protease that inactivates the small GTPase RhoA of targeted host cells by cleaving its C-terminal, prenylated cysteine, thereby releasing the GTPase into the host cytosol.	1.10125e-19
NC_015424.1\|WP_005354662.1\|722534_723443_+\|tRNA-glutamyl-Q(34)-synthetase-GluQRS	gnl\|CDD\|274810	TIGR03838, queuosine_YadB, glutamyl-queuosine tRNA(Asp) synthetase. This protein resembles a shortened glutamyl-tRNA ligase, but its purpose is to modify tRNA(Asp) at a queuosine position in the anticodon rather than to charge a tRNA with its cognate amino acid. [Protein synthesis, tRNA and rRNA base modification].	2.09157e-158
NC_015424.1\|WP_013723480.1\|729513_730041_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	9.95533e-18
NC_015424.1\|WP_005354639.1\|731240_733343_+\|hypothetical-protein	gnl\|CDD\|182330	PRK10246, PRK10246, exonuclease subunit SbcC; Provisional.	0.00510162
NC_015424.1\|WP_005335639.1\|726680_727538_+\|pantoate--beta-alanine-ligase	gnl\|CDD\|234741	PRK00380, panC, pantoate--beta-alanine ligase; Reviewed.	1.12466e-167
NC_015424.1\|WP_005354675.1\|714311_714698_+\|multidrug-transporter	gnl\|CDD\|182471	PRK10452, PRK10452, multidrug/spermidine efflux SMR transporter subunit MdtJ.	7.87217e-18
NC_015424.1\|WP_005335642.1\|723700_725167_+\|polynucleotide-adenylyltransferase-PcnB	gnl\|CDD\|236939	PRK11623, pcnB, poly(A) polymerase I; Provisional.	0
NC_015424.1\|WP_005354666.1\|720571_721114_+\|RNA-2',3'-cyclic-phosphodiesterase	gnl\|CDD\|274058	TIGR02258, UPF0097_protein_AF_2157, 2'-5' RNA ligase. This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing].	2.25335e-32
NC_015424.1\|WP_005354664.1\|721110_721854_+\|DNA/RNA-nuclease-SfsA	gnl\|CDD\|234733	PRK00347, PRK00347, DNA/RNA nuclease SfsA.	2.87019e-134
NC_015424.1\|WP_005354668.1\|717945_720393_-\|ATP-dependent-helicase-HrpB	gnl\|CDD\|236950	PRK11664, PRK11664, ATP-dependent RNA helicase HrpB; Provisional.	0
NC_015424.1\|WP_005354654.1\|727562_727913_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	7.89567e-15
NC_015424.1\|WP_005335644.1\|721973_722423_+\|RNA-polymerase-binding-protein-DksA	gnl\|CDD\|182722	PRK10778, dksA, RNA polymerase-binding protein DksA.	3.87128e-78
NC_015424.1\|WP_005354677.1\|713271_714153_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	6.31259e-37
NC_015424.1\|WP_005335659.1\|714694_715015_+\|multidrug-transporter	gnl\|CDD\|182618	PRK10650, PRK10650, multidrug/spermidine efflux SMR transporter subunit MdtI.	2.66142e-18
NC_015424.1\|WP_005354672.1\|715093_715495_-\|VOC-family-protein	gnl\|CDD\|319940	cd08352, VOC_Bs_YwkD_like, vicinal oxygen chelate (VOC) family protein Bacillus subtilis YwkD and similar proteins. uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Bacillus subtilis YwkD and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.31334e-70

>NC_015424.1|WP_005354662.1|722534_723443_+|tRNA-glutamyl-Q(34)-synthetase-GluQRS
MPVNPLSSPLARPYVGRFAPSPSGPLHFGSLIAALGSFLQARAQQGRWLVRIEDIDPPREMAGAADLILKTLEAYGLEWDGEVMFQSARHGRYDEIIDQLYRAGDLYWCRCTRREIMAAGGLYSGHCRTLGLAAEGCAARLRQHHPVYHFDDRLQGHIAVPAALAEEDFIIRRRDGLYAYNLAVVVDDMDSGITEIVRGADLLEPTVRQIALYQTLGAPVPDWVHLPLAVLADGNKLSKQNHAPALALDEVRPALWQALHFLGQCPPPELMASRIDEIIRWGIANWLLERVPASEKIPLADC
>NC_015424.1|WP_005335644.1|721973_722423_+|RNA-polymerase-binding-protein-DksA
MPTGENRKSLGPLAIAGVAPYQEKPGEEYMNDQQKAHFRKILGAWRNQLMQEVDRTVDHMKDEAANFPDPVDRAAQEEEFALELRTRDRERKLIKKIEKTLQLLEDDDFGYCEHCGIEIGIRRLEARPTADLCVDCKTLAEIKEKQMAG
>NC_015424.1|WP_005354664.1|721110_721854_+|DNA/RNA-nuclease-SfsA
MIFDPPLQSGQLVARYKRFLTDVQLDNGEVITIHCANTGAMTGCADPGTRVWYSTSDNPKRKLPNSWEIAESPAGHFICVNTARANQIARELIEQEAIAPLAGYSRLRTEVKYGEENSRIDLLLEDDEKGNCYIEVKSVTLLDEREQPGMGYFPDAVTARGAKHLRELMAMKAAGHRAVLLFMVLHSGISRMRPATHIDPHYSLLIEQAIAAGVEILCYRPHVGVQGMVAQGFIPFESGHLLPEGSA
>NC_015424.1|WP_005354666.1|720571_721114_+|RNA-2',3'-cyclic-phosphodiesterase
MAKLFFALPVKELAPELIAWRDKLPWPGQPVPQANLHLTLAFLGEADELTTRRLIAAVERQHCPPFSIRLDETGWFSRAKAAWIGPKEWPNELTVLAKALRRHGEKQRLGNGEQGYRPHVTLSRKAGEAPAILPAPNFLLQADEFCLYQSISTPDGVRYKPLACWPLRARVKEDARRANP
>NC_015424.1|WP_005354668.1|717945_720393_-|ATP-dependent-helicase-HrpB
MSQLPIVSVLPELFAALDSHTSVILQAPPGAGKSTLLPLELVRQNRLPGRIIMLEPRRLAARNIATFLARQLGEKVGERIGLRVRGESRTSSATRLEIVTEGVLTRMLQQDPELTGVSLVIFDEFHERSLHADTALAFAIESQQGLRDDLKLLVMSATLDGMALETLLPDAPVVRSEGRGFPIDYHYRPANRQQWLEPQVGAVVLEALAEQDGSLLVFLPGQGEIERLAQWLADKLPDDVTLAPLYGRLDMAAQQAAIEPAPAGRRKLVLTTNVAETSLTIEGISVVIDSGLERRASFDLKSGVTRLETRQIAKSSATQRAGRAGRLGPGICYRLWSSEVQERLAEQSPPDILTQELTGLLLDAAQWGAKVEDLPLLDMPPAAAVASAQRLLVALGAMKPEGEQQLTPAGRAMAAFGTHPRLARMLLRARELEAEGLTGIVADAAYLVALQEEDLRGSERLSVLFHRRQNALRQSAARWFERLGARPASAQGQWLGLLCALAWPDRIGKLRSGSRYQLSGGVSCDLVEGHPCQGQAALIAIEMGQNDRGSRIFIAEPIELDELARLLPELVSERQWFDWDEREERVRAERQQVIGELVLSQRPLTELSDEQKGRCLLQGIRRKGLHVLPWDESSEGLLARLRCARDWLPDEEWPAMDDESLLATLEQWLLPAVSGMTRLEQLKKLNLGDILRQSLPWPLPKRLDEALPSHFAAPTGSRVRIRYQPGQAPVIPVRIQEMFGQGSTPCVADGRVPLVVELLSPAQRPLQITADLAAFWAGSYEQVKKEMKGRYPRHYWPDNPLEAMPTKVTKKKMGI
>NC_015424.1|WP_005354670.1|715553_717872_-|penicillin-binding-protein-1B
MATQRRKRAPKKAAPKRTIWRKLFWLGFKLSLVVAAFMVVFGIYLDTKVRERFDGEKWQLPVMVYSRPLELYPSQRLSRDQMLRELNMLSYKQVRQPHTPGEYTINGNRIELIRRPFEFYDGADGARGLRLTFNGPRLEGIQSLENQRQLGYAQMDPVLLDRLNTEDREDRLLVRIAEVPDSLLVTLLTTEDRDFYQHGGVSPVAIMRAMFANLIAGRTVQGGSTLTQQLAKNFFLTRERSLWRKLQEAYMAVLIDYRYSKDEILESYLNEVYLGQNFSQGVYGFGLASYFYFGIPVNELDIDQVALLVGLVKGPSYYDPWRFPERAKTRRDLVLKLLMDHGSLTQAEYELASRQPLGIIARGQMSYGRTPAFMGLLKREIQSRFGADLLKQSGLKIFTSLDPIAQHAAERAVESGLADIEKLRGKKKLEAAMVVSDWHKGEVVALVGGRDPRYAGFNRALDARRQIGSLVKPAVYLTGLSNGLTLATPLKDQPIRIRGQDGQVWTPQNYDRKFRQSVPLMDALASSLNVPTVNLGLQVGLEKVVDTLHKLGVQQEIQPYPSLVLGAVALSPLEVNQMYLPIANQGLTQPLSAIRAVVNGDGSLLYQHDQTAKRVTDQQASWLTLFAMTKTVSQGTARALSAKFPGATMAAKTGTTNELRDSWFAGMDNNELVSIWVGRDDNTPAGLTGASGALQLFSGYMSQRGVNSLGLKMPEGVTWANFSRASGTRVTSDCPGSLQVPAKASTMGSPAGCASSVTPRSALDDWFGGFFN
>NC_015424.1|WP_005354672.1|715093_715495_-|VOC-family-protein
MTFPLFDAIHHVAIIASDYPRSRHFYHEVLGLPIIAETLREARQSWKLDLALPDGSQLELFSFPSPPERPSRPEACGLRHLAFRVSDLDRVIAHLLAHRIEVEPVRVDELTGKRFTFFADPDGLPLELYEAPR
>NC_015424.1|WP_005335659.1|714694_715015_+|multidrug-transporter
MSPFVIVLGAALIDIGANMAINRSKGFRYKGWGFLGIMLVLGAFTLLSEAVSGGQIDLAVAYATWGAIGIVGTALGGLLFFGERLKPIGWAGMMVMALAVVMLTTA
>NC_015424.1|WP_005354675.1|714311_714698_+|multidrug-transporter
MLLSRMFLARLFLTGAIVTEVAGTSSMAMIPEQGAGWMNYIPMWLLIGFSYWLLAKAAKTISIGIAFALWEGLGITLITIVSVMFLGYDVTVQELIGLALAIVGIVMVTMGETHDEPSDKSVDAEATA
>NC_015424.1|WP_005354677.1|713271_714153_-|LysR-family-transcriptional-regulator
MKLYQIELFVESANSGSIANTARRLGKSRSAVSTAIAALEVELGVELFERGANQSRLTEIGELVLDDCTRLLQAANSLQQKCKHYASGAEVALRVARDDAIPEPVWREMLASLHNQFPGTSISLVLASPPELPALVEEGFVDAAFGLITEDQERSGLNIDVLNPIRTLMVVAPSHPLAGLKRVKQQDLTDHTQVTLSYVDEFSVKSLLPVGGQHIGLSSFELMRNAVLDGLGWAVLPSPLIQSQLRQGSLLTLKHKFSLQWRDYGVYLAENAYHGKVLAWLKKSIQGYLEPFE
>NC_015424.1|WP_005335642.1|723700_725167_+|polynucleotide-adenylyltransferase-PcnB
MKRCTIFSQIANFCRKVLGKEDGEQSVESPIPARVAGQRRTLSRDQHPISRKEISENALKVLYRLNKGGYEAYLVGGGVRDLLLGKTPKDFDIATDATPEQIKALFSNCRLIGRRFRLAHIVFGRDVIEVATFRGHHHQVNTSKHVSAQSDEGMLLRDNVYGTIEEDAERRDFTVNALYYSAKDFTLHDFEGGLEDLAERKLELIGDPETRYREDPVRMLRAVRFAAKLDMTISPRTAAPIKELAPLLQDIPAARLFEETLKLFLAGDGLATYKLLREYGLFQQLFPQVAALFTPHGNSPYEQFIEQALIDTDTRVREDKRVTPAFLYATLLWGCVEARGRVLENESGLPWYDAFMLAINEVLDNQVRIIAVPRRFTTDVRDIWALQQRLTRRQGKHPERAMEHPKFRAAFDFLLLRNRVERGLGELASWWERYVASNPDVRPQLQREATRRPASGERGEARSHDGEKRSSNSRNRRRPRRRKPKVAE
>NC_015424.1|WP_005354659.1|725178_725688_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MTEVFIAIGSNLSDPLGQARRAVAALARLPESVLVEASSFYSSRPMGPADQPDYVNAVARLNTRLAPLALLDQLQKIELEQGRVRKDERWGPRTLDLDLLLYGDQVINHERLIVPHYGMKEREFVLLPLAEIAPALVLPCGTPLARLVARCPHNDLAIIAPRADVQEPL
>NC_015424.1|WP_005335640.1|725684_726479_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MSKITTASLLKMKQEGQKFTAITAYDATFAKLFDDEGAHVLLIGDSLGMVLQGGQDTLAVNMDEMVYHTRCVARGASKALVVADMPFMSYATPEQTYQNAARLMAAGARMVKMEGGDWLCDSIRHLTRNGVPVCGHLGLTPQSVHVFGGFKVQGRDEFQAQEIYRQALELQAAGIQLLVLECVPTALAERITKALRIPVIGIGAGPATDGQILVMHDAFGVTSGYVPKFTKNFLAETGDVRAAIRLYVQQVSEGSFPGPEHCFN
>NC_015424.1|WP_005335639.1|726680_727538_+|pantoate--beta-alanine-ligase
MLVVNNPVVLREQISQWRREGRAIAFVPTMGNLHQGHLTLVKEAHSHAEKVVVSIFVNPMQFDKAEDLANYPRTLEQDCAALEAAGVDMVFTPTPEIMYPQGLASQTFVEVPGLSNLLEGALRPGHFRGVSTVVTKLFNLVQPDVACFGQKDYQQLALIRKMVADMAMPIEIVGVPTVRAEDGLALSSRNGYLTAAERAIAPELARTMNWIAEQIEAGDHHLPSLVAQASQRLDNAGFRTDAIDIVDAATLESATDESAQLVILMAAYLGKARLIDNQVVTLQQA
>NC_015424.1|WP_005354654.1|727562_727913_+|antibiotic-biosynthesis-monooxygenase
MSKKVYCIAQFLPKPGQEQALFQVLQALEPNTLREDGCLQYRVTRHIASPFAEGESFPIVFNEIWQDMAAFEAHCQRAEIKAFFERYCLAEDGLAAKWNVCVYSDEPEQYDAPVKK
>NC_015424.1|WP_005354651.1|728062_729430_+|cation:dicarboxylase-symporter-family-transporter
MMFVLIASLVFCLLCFALTRIPSTVPLSRKVLAGLLLGALFGLALQLGWGADDAGVQQTLEWVNIIGGGYVSLLKVVMMPLVFTSILSAINKLEQAQSLGKISAVLIGSMLTLVMIAGVVGMTITHLSGLTAAGLLSHGSDSATLQQSMSTIDSAQTLPALLLSLVPTNFAADMAGSRSLSVIGVVIFTVLAGVALLQLKAEHPQAGARAAVAIDTLQLWVMKMVRVVIALTPYGVMALIARVVAHYPLSEILSLLGFILVCYVAILAMFAVHMVILLLIGQNPLHYLREVWGVLTFAFVSRSSAASIPLSIETQQRLGVPASIANFAASFGANLGQNGCAGIYPAMMVAMIAPMLGINPFDPLFLLTLLPVIALGSIGVAGVGGGGTFAALIVLSTLNFPIALVGVMIAIEPLVDMGRTALNVNGSIMAAMITKRLLGKQQLANVETVQTQAAS
>NC_015424.1|WP_013723480.1|729513_730041_-|rhodanese-like-domain-containing-protein
MMTLRSRTLLASLIAASFALAGCGDNQFEQEVKLEQSAVQLAQEAQQGGYQLLTVAELKTRMDKGEELVIIDTMPYEDSYKKEHIPGAKNFVFVKEAKSGDNWSEIVEGSGTAEQFQALLGEDKSRPVVIYCGFVKCGRSHNAAAWAVTQGYQQVYRVPGGIFAWKGAGYPVSAE
>NC_015424.1|WP_005354646.1|730045_730465_-|hypothetical-protein
MPALLRMLANLALGGFFLASAGFKLVSPALFIEQIAAFGLIWPSLIPPVAWGLIALELCAGLAVIANRRWGLWLVIGLLALFIPVLGYGVAIGLDISCGCLGRADLSSLPEAIVRDLLLLTLAGALLRTSRPVFPVLKE
>NC_015424.1|WP_005354643.1|730587_730995_-|hypothetical-protein
MYHALITALYTQLGLPLPVAGQTATTLTINDELVLTLAEDEDHLVIYLLLPGHAMPNTPLLNHLGDEPVFLLDQTERGETLIWAREWLDHLTVDSLLVLLERAIELAAELLTHQHDREQSTQPQHPASTTATIRV
>NC_015424.1|WP_005354639.1|731240_733343_+|hypothetical-protein
MKIASPDIDVSRHQQTSPDATPPATACLGNARLRLLDAGNREFDRGIRRGIGHRQSPELKAVKQAVRHYQAQPTPSLAGLAKIEQVLQFWIDSGKNRSRQQDPVLQKLVDDIAVRRQALAQGGKPPSFQLAWVCNEQGRVNQPIESNQQVRQWCSELARLQQEGANDLFKQELQGGLDLMFGVSEGMMARRLERVPTREEVAESHEWQLFCGTLRQALPALGELKPQATAEENGRDILLTHSQLLELGHLKEVLDLSIQQQVSKQGEIGLLRTELLTALVDGLDEPWLEREAQEKALWQGEAASGKHYQSGVRAELKSSLSAASKELKPGEPVSHKAFGGLGLVSTSALVEAFAKIEIGKWEGRRDTPVGEFAGKVALTQENKASAKAELVIGKAEGSLVFNPVNKIVNDTDGSRYTPGPHDLSLLRIGASAELVSRLGLSVEGSWTIGNLLNAKLAGSAEVVANAKLEAGAAAIMTPNGPVVSVTANASAFAGMKAEGSAQLNLLKSQYADAYSLSAKVRASANLGVGASAGATAAFGPEGAKFHTTLGVTLGVGSDVGWEGGVNAMATKAYALELAARAVSNFDQRKGEQLDGLAMAAGNENRLFELAQRVDNRIVTLATQLDELQLAASENRIRMQESLIDPELAAGRTAMAQAIDDAFGQERVDEQGGVTVPERAAERNEKLELTARLLKDHAIRV

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Crispr_ID: NC_015424_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015424_3

2842448-2842596

Orphan

Consensus_repeat	Method
TCAGGGATAGATGCTCACTTCTATCAGATTCTGATCCGGGTCGAGGAAGTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015424_3

>merge|NC_015424|3|2842448-2842596|CRISPRCasFinder
TCAGGGATAGATGCTCACTTCTATCAGATTCTGATCCGGGTCGAGGAAGTAGAATGATTCTGATAGGTGTTGCACCGTCAGGCGCCGCGCCAACCCTGTCAGGGATAGATGCTCACTTCTATCAGGTTCTGATCCGGGTCGAGGAAGTA

>NC_015424|3|3|2842448-2842596|CRISPRCasFinder
TCAGGGATAGATGCTCACTTCTATCAGATTCTGATCCGGGTCGAGGAAGTA	GAATGATTCTGATAGGTGTTGCACCGTCAGGCGCCGCGCCAACCCTG
TCAGGGATAGATGCTCACTTCTATCAGGTTCTGATCCGGGTCGAGGAAGTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015424.1\|WP_005337600.1\|2849305_2849887_+\|electron-transport-complex-subunit-RsxA	unknown	unknown	gnl\|CDD\|235352
NC_015424.1\|WP_005350837.1\|2836919_2837762_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_015424.1\|WP_005350810.1\|2843446_2845345_+\|hypothetical-protein	unknown	unknown	unknown
NC_015424.1\|WP_005350795.1\|2854411_2855044_+\|electron-transport-complex-subunit-RsxG	unknown	unknown	gnl\|CDD\|179350
NC_015424.1\|WP_005350834.1\|2839269_2840286_-\|23S-rRNA-pseudouridine(2604)-synthase-RluF	unknown	unknown	gnl\|CDD\|236698
NC_015424.1\|WP_005350838.1\|2835349_2835988_-\|tellurite-resistance-TerB-family-protein	unknown	unknown	gnl\|CDD\|377342
NC_015424.1\|WP_005350803.1\|2847011_2848601_-\|DNA-cytosine-methyltransferase	unknown	unknown	gnl\|CDD\|223348
NC_015424.1\|WP_005337582.1\|2836688_2836844_+\|pleiotropic-regulatory-protein-RsmS	unknown	unknown	gnl\|CDD\|182920
NC_015424.1\|WP_005350797.1\|2853205_2854258_+\|electron-transport-complex-subunit-RsxD	unknown	unknown	gnl\|CDD\|234844
NC_015424.1\|WP_005350842.1\|2830871_2832443_-\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|185052
NC_015424.1\|WP_005337580.1\|2836126_2836594_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|224523
NC_015424.1\|WP_005350829.1\|2840743_2842324_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225176
NC_015424.1\|WP_005350839.1\|2834035_2835106_-\|hypothetical-protein	unknown	unknown	unknown
NC_015424.1\|WP_005350836.1\|2837939_2839202_+\|cyanate-transporter	unknown	unknown	gnl\|CDD\|340968
NC_015424.1\|WP_005350798.1\|2850482_2853194_+\|electron-transport-complex-subunit-RsxC	unknown	unknown	gnl\|CDD\|235334
NC_015424.1\|WP_005350841.1\|2832565_2833984_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_015424.1\|WP_005350799.1\|2849889_2850468_+\|electron-transport-complex-subunit-RsxB	unknown	unknown	gnl\|CDD\|235347
NC_015424.1\|WP_005350807.1\|2845341_2846169_+\|hypothetical-protein	unknown	unknown	unknown
NC_015424.1\|WP_005350805.1\|2846172_2846934_+\|hypothetical-protein	unknown	unknown	unknown
NC_015424.1\|WP_005350801.1\|2848669_2849119_+\|DNA-mismatch-endonuclease-Vsr	unknown	unknown	gnl\|CDD\|226250

Protein	Function_ID	Function_description	E-value
NC_015424.1\|WP_005337600.1\|2849305_2849887_+\|electron-transport-complex-subunit-RsxA	gnl\|CDD\|235352	PRK05151, PRK05151, electron transport complex protein RsxA; Provisional.	7.87435e-116
NC_015424.1\|WP_005350837.1\|2836919_2837762_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	8.97025e-42
NC_015424.1\|WP_005350795.1\|2854411_2855044_+\|electron-transport-complex-subunit-RsxG	gnl\|CDD\|179350	PRK01908, PRK01908, electron transport complex protein RnfG; Validated.	2.65395e-108
NC_015424.1\|WP_005350834.1\|2839269_2840286_-\|23S-rRNA-pseudouridine(2604)-synthase-RluF	gnl\|CDD\|236698	PRK10475, PRK10475, 23S rRNA pseudouridine(2604) synthase RluF.	0
NC_015424.1\|WP_005350838.1\|2835349_2835988_-\|tellurite-resistance-TerB-family-protein	gnl\|CDD\|377342	pfam04391, DUF533, Protein of unknown function (DUF533). Some family members may be secreted or integral membrane proteins.	5.086e-66
NC_015424.1\|WP_005350803.1\|2847011_2848601_-\|DNA-cytosine-methyltransferase	gnl\|CDD\|223348	COG0270, Dcm, Site-specific DNA methylase [DNA replication, recombination, and repair].	9.53702e-26
NC_015424.1\|WP_005337582.1\|2836688_2836844_+\|pleiotropic-regulatory-protein-RsmS	gnl\|CDD\|182920	PRK11038, PRK11038, hypothetical protein; Provisional.	1.13312e-17
NC_015424.1\|WP_005350797.1\|2853205_2854258_+\|electron-transport-complex-subunit-RsxD	gnl\|CDD\|234844	PRK00816, rnfD, electron transport complex protein RnfD; Reviewed.	0
NC_015424.1\|WP_005350842.1\|2830871_2832443_-\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|185052	PRK15097, PRK15097, cytochrome bd-I ubiquinol oxidase subunit CydA.	0
NC_015424.1\|WP_005337580.1\|2836126_2836594_+\|acyl-CoA-thioesterase	gnl\|CDD\|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	6.84857e-55
NC_015424.1\|WP_005350829.1\|2840743_2842324_+\|alpha/beta-hydrolase	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	7.94972e-21
NC_015424.1\|WP_005350836.1\|2837939_2839202_+\|cyanate-transporter	gnl\|CDD\|340968	cd17410, MFS_CynX_like, Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.24539e-90
NC_015424.1\|WP_005350798.1\|2850482_2853194_+\|electron-transport-complex-subunit-RsxC	gnl\|CDD\|235334	PRK05035, PRK05035, electron transport complex protein RnfC; Provisional.	0
NC_015424.1\|WP_005350841.1\|2832565_2833984_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	6.05566e-135
NC_015424.1\|WP_005350799.1\|2849889_2850468_+\|electron-transport-complex-subunit-RsxB	gnl\|CDD\|235347	PRK05113, PRK05113, electron transport complex protein RnfB; Provisional.	2.27095e-126
NC_015424.1\|WP_005350801.1\|2848669_2849119_+\|DNA-mismatch-endonuclease-Vsr	gnl\|CDD\|226250	COG3727, Vsr, DNA G:T-mismatch repair endonuclease [DNA replication, recombination, and repair].	6.33141e-60

>NC_015424.1|WP_005350829.1|2840743_2842324_+|alpha/beta-hydrolase
MQAHTRRLVRRALLTLLLLLLTAWAVIAYFAWQAAPLQLWHTVVPPELSADELDSSDWQAYLTREAELFELVATEVVAKTPPEQQLASNRYYQDAPINPARFQQNWNRSYLLRPEGEVKGVAVLLHGLTDSPYSLRHLARRYQQQGFIALGLRIPGHGTVPAGLVDVDWETWLAATRLAVREARLLAPGKRPLHLVGFSNGGALAVKYALDALADPSGTLAKPDRLVLISPMIGVTRFARFAGLKAVPALLPAFANAAWLDTMPEFNPFKYNSFPVNGARQSYRLTHAIQQQVRQLAASGELAAFPPALTFQSVMDYTVSTRSIIADLYHYLPANGSELVLFDINRSTLFGPLMSSASELALHRLLPNAPGHYRLTVVGNMDPASPATQARTLATADQPEQLRPLGIDYPKEIYSLSHVALPFPMDDPLYGMAARPQQREQYGINLGGLALRGERGVLIVNPGALTRTSSNPFYPYLQQRVMETLTAPPMARSAAVTPASSGQPDAAYQAEVERFLQESDESSAPF
>NC_015424.1|WP_005350834.1|2839269_2840286_-|23S-rRNA-pseudouridine(2604)-synthase-RluF
MLANESMRLNKYISESGICSRREADRFIEQGHVFINGKRAGIGDQVQVGDLVKVNGQVIEPREADSLVLIALNKPVGIVSTTEAGEKDNIVDFVNHSTRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPVTDEFVRGMAAGVPILGTVTKKCKVKKEAPFVFRITLVQGLNRQIRRMCEHFGFEVTKLERIRIMNVSLKGLPVGEWRDLTDDELIDLFKLIEDSSSEVKPAKGDKPKAAKAPAAQSAKPGQGKKPRRDDDHEIGGRPNVPGPEAFEKKLPVGKGGAGKGAANKGGAGKGAPKGGKPAAGKPRTANTGRQKKGR
>NC_015424.1|WP_005350836.1|2837939_2839202_+|cyanate-transporter
MNQRNTDQPAGQTALLVLVILIGLNLRPFLTAIGPLSGEIGRTLSLGMDTLAWLTLLPLWLIGIGVLLTPSLRRRTSARQLLGAALLLLGVGSAMRFDAQSGALLIASAALCGLGSALVQGVLPALIKQAFAHKVPLVMGIFSACMMGGGALGASLTPRLAASLDWSRALALWSLPVLLALVWLGWKVHLPRATAVAIPHGERRLITLPRSWLLIVCFGIINSGYGIVVAWLAPAYMAQGWSAAQAGELVAWLALAQTASGLGLPLLAARKMDRRPWMGLAIAMQLAGFGGLWLAPASAPILWCMLCGAGLGGSFSLIMVIALDHLPDPRRAGTLSALMQGFGFMLAATGPWVAARLYHLFGDFAAAWQWQLGGLLLMSQLVLRLDPRHYPRVMGLPTASEPAFSAPLPASTAAQSNTPA
>NC_015424.1|WP_005350837.1|2836919_2837762_-|LysR-family-transcriptional-regulator
MLDPLLLRSFVAIIDTGSFTRAGERVHLTQSTISQQIRRLEQQLGCPLLDRAGRQVVATAEGEKLLGLARRILALLAQAEEQVTEGSVALSLGVPEDFAAGAITPVLAAFARDYPEVRLEVQSGLSHEIWQRFEAGELDLALVKQTRGKGSPLASWREPLVWVDSRDWPARERDPLPLVAFPSEGLYRQQMTEALDGLGRRWRIAYVSASLASLQGAVSAGIGVSLLPKRLMPADQLALTQWPKVAPVELALHAGVSVSEPLTRLSAALIALCDEVMGPQ
>NC_015424.1|WP_005337582.1|2836688_2836844_+|pleiotropic-regulatory-protein-RsmS
MSLETAPPEVKLAVDLIELLETNELAPELVLAALAIVKNDYERKLAEGKDH
>NC_015424.1|WP_005337580.1|2836126_2836594_+|acyl-CoA-thioesterase
MPNRELTLQFLAEPSDVNFGGKVHGGMVMKWIDQAGYACAAGWCGGYAVTVYVGGIRFLRPIQIGQLVEVHAQVIHTGTTSMHLAVDVYSRHPTETERHKTTHCIIIFVAMDEQGKPTPVPQWQPVSESDLQLQQYAKKLIALREEIDKEMRQHL
>NC_015424.1|WP_005350838.1|2835349_2835988_-|tellurite-resistance-TerB-family-protein
MKQMLEQLLGAGKGWLNEGGDKRKGQMQGALAGGALGLLLGNKKVRKYGSKAAAVGGAAALGGLAYKLYQDWQAQQAAPAQPTHPISGLEGNALDARAALLVRAMVAAARADGHIDGAERQKIQEYLTEQGQSDVARWIDAELARPLDPHALAREVTDMELATEVYLASLLAIEVDHFMERGYLDELARALKLDDNLKGSIERQVAQLNAPA
>NC_015424.1|WP_005350839.1|2834035_2835106_-|hypothetical-protein
MSTSPAELAKYYSVDDLTSATTGGGRLNNLLLSVQKGLPLSIWSQQYLESKGLNALLGFLTGSLSKEEFYRRALLEREQRIVIAKKRQLELEAIKIAEQKASALRYEMLQAQYEAERIKRENDPKFIARRINQELRRKFGIESFVEKHHFKQLMKILRTLDAKSRLSELDSIWLKVEGREYQTDEIWHAYHRIEADFYISEYKKTCDPWQAVNASAHLRKCAAAASAVELLSAIPVKDQEHAKLKSAIRTTHGGALRDLGKRTDALKMGAEAHALQPNNFRPCTLLGALNIEQGNIEEGHNWYLMAEARGAKRDSIEYELRSLLLRMSEDKRHATIAELLRIAPREYGWLRRPLKR
>NC_015424.1|WP_005350841.1|2832565_2833984_+|PLP-dependent-aminotransferase-family-protein
MSLYQQLADRLQSQIDDGIWQPGERIPSIRQSCKTHGLSPMTVLQAYQLLESQGRILARPQSGYYVKAASPQVVQHTPSQTHYSGSVDINDLVFEVLQASKSRDLVPLGMSVADPTLFPHPQLGRALASCMRKLDPFSTVADLPPGNEALRRAIAQRYASDGVAVNPQEIIITTGAMEALSLSLQVLTEPGDWVVVESPTFYGALQAIERLKLKAVEIPVIPGVGIDLALLEDALTRIPVKACWLMGNVQHPLGHTMPDSHKARLMALLNSHGVPLVEDDVYAEVYFGRERPKPIRHWDQRGDSLLCSSFSKCLAPGFRVGWVVAGPHAERVQRLQLMSTLSTNVPSQLALAEMLRQGGVDAHFRRLRHTLAQRQQQMRAALQRLLPDEVRISSPDGGYFLWLALPAHFDSRALHAKALGSGFSVAPGALFSSQGQHNHCLRLNSSHPWSEQLEQALFKLAELINRQIAQGT
>NC_015424.1|WP_005350842.1|2830871_2832443_-|cytochrome-ubiquinol-oxidase-subunit-I
MINPDDVVSLSRLQFGATALFHFLFVPLTLGLSWILVIAESAYVMTGKVIYQDITRFWGKLFGINFVMGVTTGITMEFQFGTNWAYYSHYVGDIFGTPLAIEGLMAFFLESTLVGLFFFGWDKLSRGKHLLVTMLVALGSNLSALWILIGNGWMQNPVGAEFNLLTQRMELVDIAAVLFNPVAQVKFVHTVAAGYVAASMFVMGVSSWYLLRKTEVQFALRSFAIASGFGLAAILSVIVLGDESGYRTGEVQKVKLAAIEAEWETEPAPASFTLFGFPDQQAETTHAAIKIPYLMGIIATRSIDEAVTGLKDIKVQNEARIRSGMVAAEALDQIRQGADTPANRARFEQHGKDLGYGMLLTPYASNIAKAGEAEIAKAVDDSIPPVAPLFWGFRVMVGLGVTMLGLMVVSFVQLCRNRLQDSPRLLKTLLWSIPLPWIAIEAGWLVAELGRQPWTISDVLPVSASVSLLQPGQLWFSLIAICSIYTLLLVVELFLLRHVIRKGPAILHTGRYSGEQPELARIA
>NC_015424.1|WP_005350810.1|2843446_2845345_+|hypothetical-protein
MTVPELEFLKNEAGEEEGLSDAGIETFRDDPYASCAREAGQNSRDAGLDGKPVRMTFDLKQEDIANIPFHASLARTLNCCSSQAHAEKEKEFFKNACAVMSRDTLPILRISDFNTKGLIGPPEKSGTAFHSLLKSSGVSKKDSETSGGSYGIGKNANFAVSDLQTVMYSTLYVGEDNEHHFAAQGKVKLVSHTDGNNVHRRAIGYWGFSDNFRAITNASQVPAWMQRSDVGTSIFCVGFRESEDWAERMAFSLVSNFFVAIQNEDMEFEVDSGKIKINSNTLEELLSNDAIEETADRSGHSSELEFARQLYKCLVAETATEEIIDIPNLGKMKVRILMEVGMPRRVGFVRNGMLITDNLRNFGHVLARFNGADFIALVEPNDDSASKVLKKLENPAHNAFSAERISDPEGRRTTEKAMRKLGEKLRNIIKSYTTIPVQDSLTLDELGELFSYKGTSDTEPDPNSENDPEKYTYSAAHVNTRKNSTYRHNVKDDGQNGRHKARNSTTSNGGSSSQPISKGAEDTDRSDMHTALNLLDVRNRIAPDDKGIAKSRTLYFSSPVTGKIELILQATGVNTPESLHPVNANGASINNKKLLLDVKEGTRNSIYVEFDEPYDGPIEIYARKISSMGETK
>NC_015424.1|WP_005350807.1|2845341_2846169_+|hypothetical-protein
MRITENTRFPHPVLGLDSGDFVAGEFSIQIQVKEDRSAGTVTLEHAITLTEPAIRALVESNQASVGCIIKCADTFFSDLKKMTWSTGITDFPPDQLLNQVTFRPIVWLKKDLDNWDPGTINSEFSPPISLKKSDIIAIGNELMISVGQAKLTPIESIFELVKSERIPDGELQVDISGSCIGLLVSEKTFQTLSELRLQSHSKDILMSSIYLPAVMEVLDILRNDSKEYEFQRWYQPFLAKCHAKGIDIESNHSILEAAQCLLEHPISHLGKIAEE
>NC_015424.1|WP_005350805.1|2846172_2846934_+|hypothetical-protein
MSYVPLKYLSQSVLDSLGNDISSNRERYISGDFSDLAKENGWEIKSNTVNVDLDALNELNGTKSTAEADIRNSLIVYKSLQGMTPALAREERLWVRLTHVECLQYSRARWIKNVNDEALDNTVKKHFFARGRTGVRDDNAISRLWWNMHVATIANPESPESALQLILKTADIRQAIVERPNIASRKHLAQAIVRAMDAIPWLTSSEVIFREFMKEMNRDAGGILFEAISASEADCILRKYASRVKFNLENSEK
>NC_015424.1|WP_005350803.1|2847011_2848601_-|DNA-cytosine-methyltransferase
MSIFSSSIPVVDLFAGPGGLGEGFSSLNDGKAFEIRVSAEKDPIARETLRLRSFYRLLKNHRRDCLQDYYQYCNGDADQPYTEKTNDLWEKAGLEAMCLEIGSESGNQRLDQAITKALENRNESQPWVLIGGPPCQAYSLAGRSRNKGKSDYKPEEDHRHFLYKEYLRIIQRNRPDIFVMENVKGILSSKINGDFIFHQILRDLANPNAALDVSDDDLRYQIVSLVSDEVFRDGDDPKAIDARKFIIKSEEYGIPQARHRVILLGIRDDRILTELPKLSQEEPITVKQVIGDLPVLRSKLSKQEDSYENWVSSVNDQLMELALNAPLGAEHIKPLANKLSAVAETLEASHPGSLRLEKDEKSVFIGNYKLEKWYSDPKLKVWLNHETRGHRIDDLARYGFAACFAEEYGRSPKGHTDFCLPGLAPDHKNWESGNFSDRFRVQLADAPSTTITSHISKDGHYFIHYDPRQCRSLTVREAARLQTFPDNYFFQGGRTQQYHQVGNAVPPLLANKIAKLVLNIILSKHNHHK
>NC_015424.1|WP_005350801.1|2848669_2849119_+|DNA-mismatch-endonuclease-Vsr
MDVVDTATRSAMMAGIKSKNTRPELTLRRYLHGLGFRFRVHVKELPGKPDIVLPRYRLCIFVHGCFWHRHPGCRFAATPKSNTEFWLQKFAANTERDELVEKQLHEAGWRVFRIWECGLKNADFQTLGWLPERIRGTTSFLDWPEFETL
>NC_015424.1|WP_005337600.1|2849305_2849887_+|electron-transport-complex-subunit-RsxA
MTEYLLLLIGTVLVNNFVLVKFLGLCPFMGVSGKLETAIGMGLATTFVMTLASASSYLVEHYILLPLDIAYLRTLAFILVIAVVVQFTEMVVRKSSPTLYRLLGIFLPLITTNCAVLGVALLSINERHDFIQSVIYGFGAATGFSLVLILFAAMRERLVAADVPAPFRGVSIAMITAGLMSLAFMGFTGLIKI
>NC_015424.1|WP_005350799.1|2849889_2850468_+|electron-transport-complex-subunit-RsxB
MIHILFAILVLTLLALAFGIILGFAAVKFHVEADPIVDQLDALLPQTQCGQCGYPGCKPYAEALANGDQINKCVPGGEATMRKIADLMGVEPQPLGGSDEAAVPVKKVAFIHEDQCIGCTKCIQACPVDAIVGATKAMHTVIANECTGCDLCVDPCPTDCIEMIPVPTTVDNWKWDLNNVHVPGKIPVKIVE
>NC_015424.1|WP_005350798.1|2850482_2853194_+|electron-transport-complex-subunit-RsxC
MHSLLERIKAGTLWDFHGGIHPADNKLQSSQSPVVDAGLPPRLIIPLRQHAGPAGDLLVQVGDKVKKGQPLTRYAKGRVVPVHASTSGTITEIGNHTVAHPSGLGDLCVILTPDGEDEWGERNGKADYWNLERGELLERIQQAGVAGLGGAVFPTHSKLDGRGQLTEILIVNGLECEPYITTDDRLMQQYADEIMDGIRVLKHLLKPKLTLIGVEDNKPEAIEQLTRHATDEDVLVKTVPTKYPSGGAKQTIELLTGRQVPKGGRAVDIGIMVLNVATVFAIKRAIIDGEPLIERIVTLTGESFKQPGNAWVRLGTPVRWLLQRFELQPEAEQRVIMGGPMMGFTLPHAMVPVVKATNCLLAPTQAELPAPGPEQPCIRCSACADACPATLLPQELYWYSRAKEYDKAEKLNLMDCIECGACAWVCPSEIPLVQYYKIAKDDIREARAEAEKAERAKQRFEAKQARFEREKAAREARHAEAAAQRRQTMTAAGGEDPVAAALARIKAKQDAPITAITATAEGLPDNSAVIAAREARKREAEARRAAKLAESANSETAAAAQSTEAVDPASDPKKAAIAAALARAKAKKAAQAGDSAEPVTAEAVAAPAVDADQQKAEVDPKKAAIAAAIARAKAKKAEASGEPVSAANSATTDADTQSDAPADPKKAAIAAAIARAKAKKLAQQGDSAEGNLTATAGTSETAATQNDAPSAASEAVDPKKAAIAAAIARAKAKKLAQQGESAGAEGAQSEPTASAQTRDVALAKGEVTTSQSDTAASEAVDPKKAAIAAAIARAKAKKLAQQSASTSAEVESAGTQVESAGTEGERAPAEPMQTDAASSEQPLAVTAAPEASAPAADAPVDPKKAAIAAAVARAKAKKLAAEAARAAESAAEDAPSADRTTTR
>NC_015424.1|WP_005350797.1|2853205_2854258_+|electron-transport-complex-subunit-RsxD
MFNIATAPFAHNRKQTRTLMLLVILACVPGLLAQTWFFGWGSFIQILLALVTALLCEALVLKLRGRAIKPALMDGSAALTAVLIGLSLPPLLPWWMLVVGTAFAIIVAKHLYGGLGQNLFNPAMVAYVLLLVSFPVQMTSWLPPESVRAYGLGFGDAASVIFTGFSLDGYSMAQLKQGVDGLTMATPLDTLKTGLTQGLTTGEILSGPLFEGWGGIGWSWVNLGYLLGGLFLLQQKVINWRIPTAILGALLAASTIGYLVSPDATATPMFHLFSGATMLGAFFIATDPVSACTTPRGRLVYGVLIGMLVYIIRRFGGYPDAFAFAVLLANLCVPFIDSLTRPKVYGARRQ
>NC_015424.1|WP_005350795.1|2854411_2855044_+|electron-transport-complex-subunit-RsxG
MLKSMRKNGLILAMFALGCTALVVLTNELTKDKIAHQQQLEKQQTLSVLLPEGSYDNDLVASCKQVTSRKYLGSDQPQALYTASKNGVVTGYALEAIAPDGYSGAIRIVAGFDAKGTITAVRVLAHNETPGLGDKIELKKSDWINSFAGKFLTHDNEPQWAVKKDGGEYDAFTGATITPRAVVKAVKNLLKLQQEQPELLSNAPACPAAN

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Crispr_ID: NC_015424_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015424_4

2881185-2881343

Orphan

Consensus_repeat	Method
AACTGATCCCATCATCAAGGTGCAACAGGCATCGAGAAGTGCAGCCATCACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015424_4

>merge|NC_015424|4|2881185-2881343|CRISPRCasFinder
AACTGATCCCATCATCAAGGTGCAACAGGCATCGAGAAGTGCAGCCATCACCGACACCCTCTTCGCCTTCCCGGTTCGTTTTCTGGAGGTGAAATATGCACGCAGTAACTGATCCCATCATCAAGGTGCAACAGGCGTCGAGAAGTGCAGCCATCACCG

>NC_015424|4|4|2881185-2881343|CRISPRCasFinder
AACTGATCCCATCATCAAGGTGCAACAGGCATCGAGAAGTGCAGCCATCACCG	ACACCCTCTTCGCCTTCCCGGTTCGTTTTCTGGAGGTGAAATATGCACGCAGT
AACTGATCCCATCATCAAGGTGCAACAGGCGTCGAGAAGTGCAGCCATCACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015424.1\|WP_005350700.1\|2890602_2892252_-\|phosphate-ABC-transporter-permease-PstA	unknown	unknown	gnl\|CDD\|227318
NC_015424.1\|WP_005350708.1\|2885586_2886489_-\|homocysteine-S-methyltransferase-family-protein	unknown	unknown	gnl\|CDD\|376828
NC_015424.1\|WP_005350749.1\|2873530_2873926_+\|nucleoside-diphosphate-kinase-regulator	unknown	unknown	gnl\|CDD\|180236
NC_015424.1\|WP_005350714.1\|2882236_2883028_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366132
NC_015424.1\|WP_005334071.1\|2874119_2874710_+\|transcriptional-regulator-UhpA	unknown	unknown	gnl\|CDD\|182408
NC_015424.1\|WP_005350712.1\|2883196_2884036_+\|sterol-desaturase-family-protein	unknown	unknown	gnl\|CDD\|225546
NC_015424.1\|WP_013723917.1\|2886782_2887325_-\|hypothetical-protein	unknown	unknown	unknown
NC_015424.1\|WP_005350740.1\|2877675_2878809_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_015424.1\|WP_005350746.1\|2874706_2876227_+\|signal-transduction-histidine-protein-kinase/phosphatase-UhpB	unknown	unknown	gnl\|CDD\|236945
NC_015424.1\|WP_005350743.1\|2876248_2877583_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|183266
NC_015424.1\|WP_013723913.1\|2870317_2871706_+\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|224699
NC_015424.1\|WP_005350738.1\|2879329_2880130_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270347
NC_015424.1\|WP_005350710.1\|2884161_2885577_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129983
NC_015424.1\|WP_005350752.1\|2872547_2873285_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366132
NC_015424.1\|WP_005350756.1\|2871778_2872465_+\|hypothetical-protein	unknown	unknown	unknown
NC_015424.1\|WP_013723912.1\|2868908_2870306_+\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|224699
NC_015424.1\|WP_005334102.1\|2889650_2890469_-\|phosphate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|184582
NC_015424.1\|WP_005334094.1\|2887344_2888664_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NC_015424.1\|WP_005350722.1\|2881385_2882129_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_015424.1\|WP_005334097.1\|2888854_2889565_-\|phosphate-signaling-complex-protein-PhoU	unknown	unknown	gnl\|CDD\|182974

Protein	Function_ID	Function_description	E-value
NC_015424.1\|WP_005350700.1\|2890602_2892252_-\|phosphate-ABC-transporter-permease-PstA	gnl\|CDD\|227318	COG4985, COG4985, ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism].	1.01428e-93
NC_015424.1\|WP_005350708.1\|2885586_2886489_-\|homocysteine-S-methyltransferase-family-protein	gnl\|CDD\|376828	pfam02574, S-methyl_trans, Homocysteine S-methyltransferase. This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.	1.05036e-71
NC_015424.1\|WP_005350749.1\|2873530_2873926_+\|nucleoside-diphosphate-kinase-regulator	gnl\|CDD\|180236	PRK05753, PRK05753, nucleoside diphosphate kinase regulator; Provisional.	5.56507e-57
NC_015424.1\|WP_005350752.1\|2872547_2873285_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|366132	pfam00497, SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3.	1.87131e-16
NC_015424.1\|WP_005334071.1\|2874119_2874710_+\|transcriptional-regulator-UhpA	gnl\|CDD\|182408	PRK10360, PRK10360, transcriptional regulator UhpA.	1.46965e-124
NC_015424.1\|WP_005350712.1\|2883196_2884036_+\|sterol-desaturase-family-protein	gnl\|CDD\|225546	COG3000, ERG3, Sterol desaturase [Lipid metabolism].	2.8452e-37
NC_015424.1\|WP_005350740.1\|2877675_2878809_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	7.32388e-57
NC_015424.1\|WP_005350746.1\|2874706_2876227_+\|signal-transduction-histidine-protein-kinase/phosphatase-UhpB	gnl\|CDD\|236945	PRK11644, PRK11644, signal transduction histidine-protein kinase/phosphatase UhpB.	0
NC_015424.1\|WP_005350743.1\|2876248_2877583_+\|MFS-transporter	gnl\|CDD\|183266	PRK11663, PRK11663, glucose-6-phosphate receptor/MFS transporter UhpC.	0
NC_015424.1\|WP_013723913.1\|2870317_2871706_+\|alkaline-phosphatase	gnl\|CDD\|224699	COG1785, PhoA, Alkaline phosphatase [Inorganic ion transport and metabolism].	6.13619e-123
NC_015424.1\|WP_005350738.1\|2879329_2880130_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270347	cd13629, PBP2_Dsm1740, Amino acid-binding domain of the type 2 periplasmic binding fold superfamily. This subfamily includes the periplasmic binding protein type II (BPBII). This domain is found in solute binding proteins that serve as initial receptors in the ABC transport, signal transduction and channel gating. The PBPII proteins share the same architecture as periplasmic binding proteins type I (PBPI), but have a different topology. They are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBPII proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the family includes ionotropic glutamate receptors and unorthodox sensor proteins involved in signal transduction.	1.72737e-131
NC_015424.1\|WP_005350710.1\|2884161_2885577_-\|amino-acid-permease	gnl\|CDD\|129983	TIGR00905, Arginine/ornithine_antiporter, transporter, basic amino acid/polyamine antiporter (APA) family. This family includes several families of antiporters that, rather commonly, are encoded next to decarboxylases that convert one of the antiporter substrates into the other. This arrangement allows a cycle that can remove proteins from the cytoplasm and thereby protect against acidic conditions. [Transport and binding proteins, Amino acids, peptides and amines].	6.94463e-159
NC_015424.1\|WP_005350714.1\|2882236_2883028_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|366132	pfam00497, SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3.	2.16015e-13
NC_015424.1\|WP_005334102.1\|2889650_2890469_-\|phosphate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|184582	PRK14236, PRK14236, phosphate transporter ATP-binding protein; Provisional.	0
NC_015424.1\|WP_013723912.1\|2868908_2870306_+\|alkaline-phosphatase	gnl\|CDD\|224699	COG1785, PhoA, Alkaline phosphatase [Inorganic ion transport and metabolism].	4.45795e-133
NC_015424.1\|WP_005334094.1\|2887344_2888664_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	3.0198e-133
NC_015424.1\|WP_005350722.1\|2881385_2882129_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	5.16163e-154
NC_015424.1\|WP_005334097.1\|2888854_2889565_-\|phosphate-signaling-complex-protein-PhoU	gnl\|CDD\|182974	PRK11115, PRK11115, phosphate signaling complex protein PhoU.	2.86228e-161

>NC_015424.1|WP_005350738.1|2879329_2880130_+|transporter-substrate-binding-domain-containing-protein
MIKKLILSTLLFCGIATAAPTPAPTSTLDAVLERGVLRVGFDAGYQPFEMTNKQGQYIGFDVDLAKMVAKEMGVKVEFVNTAWDGIIPALLTNKFDVIMGGMTVTPQRNLRVNFADPYIVVGQTIVLRKEKAGEIKSFTDLNDPKYKIAVKLGTTGEQAVKRLIPKATLLQFETQDDAKLEVINGKVDAFVYDLPYNAIFASQNQGAVVHLDKPFTFEPLAWAIRKGDQDTLNWFNNYLRQIKGDGSYDRLYKKWFESNAWLKQLK
>NC_015424.1|WP_005350740.1|2877675_2878809_-|GGDEF-domain-containing-protein
MDASLLLKLDIFTLMIMALCGYCLGFLTLTIIRVTHNDIPGVGVWWWSSLFAMLGQAGFASLLLTPTPYGSWVGNVFLIFHVSLLLVAQRCFFRQSPGWPVCWGFILLFAAVMTWSVAIDGRIAVRVMISSATFLMLSTLIIWQLWRHGRPDYQVAVWVLIGLNLVLIAMTLMRMFTVWGEVIESPFQRQLFNVLPYVSMLVGSSMLTFGVLLLCNQHRALALRYQASHDPLTGLLNRRGFMERLARGRPAQQGALVVLDLDDFKQINDRHGHEVGDRVLEQVGLALRELEGVLASRFGGEEFVLLFRHATAEEAIARCQSLRVQLAASEVEGIHITVSMGIAHWQGEWHFDSLFSRADDALYRAKREGKNRVCQAA
>NC_015424.1|WP_005350743.1|2876248_2877583_+|MFS-transporter
MLSFMRSAPHRPLIRDQAEIDATYRHWRLHLLLTMYLGYAVFYFTRKSFNFAMPDMLASGMLDKSDIGMLWTLFYITYGCSKFFSGIISDRANPRYFMGVGLMATGVINILFGLSSALWMFAALWVANAFFQGWGWPPCSKLLTSWYSRTERGVWWSAWNTAHNVGGALIPLIVSTIALQHGWRYGMIVPGLIAIIAGLFLCWRLQDTPSAMGLPTVGEWRKDAMELAQQTQDAGLSHRQILRKYVLGNPYIWLLACCYVLVYVVRTAINDWGNLYMTEQRGFNLMSANSAISMFEVGGFIGALVAGWGSDKLFNGNRGPMNLIFAVGILLAVGSLWLMPFFSYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKNSAGAATGFVGLFAYMGAALSGYPLAKVMEIWHWNGFFVVISVAAGVSALLLLPFLKAQAPRTAQANAE
>NC_015424.1|WP_005350746.1|2874706_2876227_+|signal-transduction-histidine-protein-kinase/phosphatase-UhpB
MISRFASYVAIALAACFIFAAGWFCLWSISLHLAGGPALAVLLFPFGLRLGLLLQSPGHYWPPLLLCEGLLLYWLNLEVGLPHWPWLVAGSLLTLLPLLIARRQQVRNDWQQLLLLLATVTAAALLQALLWHLAGEDGLSALLLSLTGGLTLTSTCMLIWHYLTRATWVPLGPALVDQPVEWRFRHLVWYLLLFVLSLWLQLGLPNSLVRFTPFCLAIPIIAMAWRYGWQGALLATLMNTIALLASQAWHDHPLDLLLSLLAQSLTGLLLGAGIQRQRELNQALTRQLAHNRQLTERLLETEESIRKEVARELHDDIGQTITAIRTQAGIVRRLAPDNAGVGQSSALIDTLSLGIYDAVRGLLGRLRPRQLDDMTLEQAVRALLRELELERHGIVTRLEWQLADRDLSDAQRVTLFRVCQEGLNNVVKHANAHSVTIRARACGEQLQLVLEDDGRGLPESRPQQGYGLLGIRERVQALGGSLQLSCIHGTQLTVNLPSRRREESHG
>NC_015424.1|WP_005334071.1|2874119_2874710_+|transcriptional-regulator-UhpA
MIKIALIDDHQIVRSGFAQLLNLEPDLQVVAEFGSASDALAGLPGSGARVCVCDISMPDQSGLDLLKQLPSGLAVVMLSVHDSPALIEQALQTGAKGFLSKRCSPDELIAAVRTAAQGGCYLTPDIAQKLASSSRDPLTNREREIAQLLAQGLEVKAIAEQLGLSPKTVHVHRANLMDKLKVSNNVELAHRMLDSW
>NC_015424.1|WP_005350749.1|2873530_2873926_+|nucleoside-diphosphate-kinase-regulator
MKQPHLVISSLDLDRIEQLLGTHPQHLALQEELDRAEIREPADMPPDVVTMNSKVRFKMQSSGNEFCLTLVYPRDAKGDESNISVLAPVGSALLGLKVGDSIAWPGPAGRTIEVEILEVVYQPERAGELHR
>NC_015424.1|WP_005350752.1|2872547_2873285_+|transporter-substrate-binding-domain-containing-protein
MRALCLPFFALLLLLVHTGAQAIVLVAAELPPYVIRSSHGKPSGVAIEIMEEAARRLKEPLTIELMPLPRALTQTIHRPDVLMIPPVRSSQREHLYQWVTPILDEQFLIVSDRRFHPKALKSSDLKNLDVGVLRYSFGQHLLKQRIGIRGETVADEQLNAHKLHRGRIDAWVAAWNVILYAQQQDKRSSQQLVRGEVLMNTQLFLAAHKDFPFKQAQRWQAVIDEMRHDGTLARIIRQYNYQAPE
>NC_015424.1|WP_005350756.1|2871778_2872465_+|hypothetical-protein
MMRLLLSLWLLGSTLAFPLHADDTPPDLAARISYHDRNTGSDGIARESVWQEKWLRVGNQVWSQRLIPLPLARAYHATHDATPGHKHFTHQMAARWVSRSDEGELQLRYADSWHNQLVEVPVEEYGQVAFKPDWPRIRHLVNPTLIEGMTPLDEAAPEQARWYEKREGQQRTRILWSSQWQIPLVVESASLDGYRSYRMEVTLRKLPAQLPWQQLADYEVRDLRDFFD
>NC_015424.1|WP_013723913.1|2870317_2871706_+|alkaline-phosphatase
MSKQMKSIKHTLVCAALFSALGATSQAQAGDAKNVILFIGDGMGPTVLTATRLFKVGEEGNLEMMKLPRSARIKTFSNDAQTTDSAPSMAAYTTGVKMNNEVIAMSSDTKAVAPGKDVNGNKTVNNCSSDNGKPVPTILELAKAAGKSVGAVTTTELTHATPAATYAHICHRDAAYDIAAQAVPGGAGFNQALGDGVDVLMGGGANHWTPYSASNKGGRNDNRDLTAEMKAQGYSYVTTQSELAKVTSGKVLGLFSSKSHLDYELDRVAKGAANTQPSLSEMTAKAIDLLSKNSQGYFLMVEGGRIDHALHGTNAKRSLTDAVALDEAVKTALGKVDLNNTLIVVTADHDHTMTINGYSAKGNPVLDLVKNSDGSTQNDVDGKPFTTLVFGNGPNRAAVRPVLTSDQVMANDYLQETGVKLTSETHGGGDVMLFADGAGSNRFKGTLDNTKVFGKLREALGL
>NC_015424.1|WP_013723912.1|2868908_2870306_+|alkaline-phosphatase
MRKMAGLAVMIGAALAAGCKSDNDTVATKPAAQPTNVIFFLGDGMGLNTLTAARIYGVGEEGDLTIDTLPETAFIKTFSHDAQVTDSAPSMAAYMTGVKSNNGVISMDGDATYESDCSKSAGKPVTTLLELAKADGRGTGVVTSTRVTHATPAATYAHICNRDLEADIAVQLVPGGKGYNSALKEGLDVVLGGGSSFFLPKADKGKREDGRNLISEMQAKGYQFASNLDELNKADAGKPLLGLFGSSHMKYDLDRPASEPSLAQMTLAAIKQLKGKEKGYFLMVEGGRIDHALHDTNAKRALQDTIAFDNAIKAAIDEVKKSDPELKNTLIVVTADHDHTLVLNGYAKRTGKTTADNPGVLGLVRNYETGEPSKDSEGMPYTIIGFGNGYNRVDGPRSSVAPLDDATVSANDYHQEVVVKVGEIGNETHGGTDVFLGAIGKGADSFHGSLDNTAVFGKIKAAAKL
>NC_015424.1|WP_005350722.1|2881385_2882129_+|amino-acid-ABC-transporter-ATP-binding-protein
MRAATDPIIKATGVEKFYGSEVHALKNVSTQVAEGEVVVIVGPSGSGKSTFLRTLNQLETINDGNIVVDGICLTEPGDVNKLREEVGMVFQSFNLFPHLTVLDNICLAPQKVRGLSRREAEDRAKALLLKVGLSVKAASYPSQLSGGQQQRVAIARALAMQPRIMLFDEPTSALDPEMVGEVLDVMKGLAREGMTMVVVTHEMGFAREVADRVLFMESGELLVDEKPADFFDNPPSPRLRQFLSQVL
>NC_015424.1|WP_005350714.1|2882236_2883028_-|transporter-substrate-binding-domain-containing-protein
MRVWCCLLLGLCMMAHAKTRVEILADAAYPPYSWQEGEEVRGIYADIIREVTSAMPDYEVVLKPMPWRRGLSMVEQGAAFAIFPPYYMPDTRPYMWPYSQPMLDEELVVMCGASVAANTPQARFPLDYHGLRFGMNAGFAVGGDAFWQAVKEKQIDVEEVKSNRENLLKIVRGRVDCTINDRLSLLYELLNMIKADQLAVADMSLLKQGPVLSKEQGFLGYSRKGEYPYKQAFIDQFDKELYQLKKRDGVKVIVERYLGKSPR
>NC_015424.1|WP_005350712.1|2883196_2884036_+|sterol-desaturase-family-protein
MDVQLLLLYLSPIFLAFIGWEMLYLRKHGAAFPTATYQWRDLFANAALALMHQGGDALAAIAIAYLYDTLWGWRLFDIELTFWSVLLLFLLQDLCYWLFHFTSHHVRWLWASHVVHHSSERLNLSTAFRQSLMYPISGMWLFWIPMIVIGFPPEAVVTTVLLSLGFQFFVHTQVVGKLGWLEWVFNTPSHHRVHHASNAKYIDRNFAGVLIIWDRLFGTFVEEDPAEPCRFGITKPINSFNPLTLTFHEWRDMLHDARGLPWRQKLAVLFGKPAGPASR
>NC_015424.1|WP_005350710.1|2884161_2885577_-|amino-acid-permease
MKESKIGLWSLTALVFSSMVGAGIFSLPQNMAEVAGARAVLIGWGVTGVGILALAMSFLYLSRLRPDLDGGIYSYARAGFGDLVGFFSAWGYWLCATIGVVGYLVIAFAALGSFIDTPEQVWFGEGNTLAAFVGESCILWAVHLLVARGVQQAALFNLVATLAKSLPLLLFILFACYWFDPVTFAADQQGSSLAVPVSEQVRNTMLITLWVFTGIEGAAVLSARARNRRDVGTATVLGVVLALLLYVLISVLALGILSRPELAALPNPSMAGLMAQMTGSWGKLLISVGLIVSVLASYVSWTLFSAEVPFSAARHGAFPAIFRRQNRNGTPIASLWLTSLTVQTCLLLVWLLGKGYTSLLLISTSMILVPYLLIGLFLLKLSFSKKGEGGQGRRLMQAVALVSSGYGFWLLYAAGVEYLLLSLLLYGPGLLLFLYSRRQLGADLCLSGRERLLAGVTLLSLIPAVWSFAHL
>NC_015424.1|WP_005350708.1|2885586_2886489_-|homocysteine-S-methyltransferase-family-protein
MKTRELWVLDGGMGRELARRGAPFRQPEWSALALMEAPETVRDVHQAYVASGARVITTNSYALVPFHIGDERFFADGEGLAALAGQLAREVADEQKGAVQVAGSLPPLFGSYRADLFKADRVSELATPLIRALSPHVDIWLAETMSLIAEPLALKALLPDDGKPFWVSFTLEDEAPGNEPRLRSGERVADAVTMLVVAEVDAILFNCCQPEVIEGALEVACTRLQALGRADIRLGAYANAFPPQPKEATANDGLDEIRGDLGPLDYLGWAERWLAAGASLIGGCCGIGPEHIQALSSRLR
>NC_015424.1|WP_013723917.1|2886782_2887325_-|hypothetical-protein
MKMQSHSRALACVALALALGACSQSAPRKATVAAKPVAPKPAVVVPQPDPDAVVQSGMAEPSPVFDEQYHGPDQGSLESVTALFARGYIESAMRETMLAAVHNDYQLLGMRDVRLTDPVSKFLTSEQAATTAHDYLYAGVQRRLGRPLSPAQWEQIWRGLPQQGRVSDWVKQIKRVLAGR
>NC_015424.1|WP_005334094.1|2887344_2888664_-|HlyC/CorC-family-transporter
MSFADSLFFLMLLVGGSVFFSLSEISLAASRKIKLQVMADEGNRQAEKVLALQAQPGNFFTVVQIGLNTVAILGGILGESALNPAIKGIVSQFYQGPWLGEISSGASFVFVTGMFILIADLMPKRLAMTMPEQIAVVVVRPMLFFVTVLMPLVWVFNGLANSLFRLMRVSTVRNDEITSDDIYAVMDAGAEAGVIQREEHQLIENVFELQSLGVTSAMTARESLIYFTLQESEESIKAKIAEHPHNKFLVCDHNLDSIKGFVDAKELLIRVIGGQSIDLIGGNLVQNVIIIPDTLNLYEAMEYFKNHRGDFAVVMNEYALVVGIVTMNDLMSTVMGEWATHVVEEQIVQRDENSWLVDGVTPISDVMRAFDIEEFPENQNYETIAGFIMYMLRKIPKRTDSVKYAGYKFEVVDIDSYKIDQLLVTRVEPAVAEKPAQES
>NC_015424.1|WP_005334097.1|2888854_2889565_-|phosphate-signaling-complex-protein-PhoU
MDNMNLNKHISGQFNAELESVRNQVLVMGGLVEQQLTDAIAAIHDQDLDAARKIVANDHKVNAMEVAIDEECTRIIAKRQPTASDLRLVMAIIKTITDLERIGDVADKIARMLTDNANKPQPPLVSLENMGRRTIKMLHDVLDAFARMDLDAALAVYKEDDKVDREYESIIRELMTYMMEDPRTIPQVLNVLWAARAIERVGDRCQHICEYIVYYVKGKDVRHTKADDLGTLLGKG
>NC_015424.1|WP_005334102.1|2889650_2890469_-|phosphate-ABC-transporter-ATP-binding-protein
MINVTTTSTQHTALDLLNLTPEQTALEVKDLNLYYGSKQALFNVNMKIPKGQVTAFIGPSGCGKSTLLRCINRMNDLVEICRIEGEIQLHGHNIYDKSVDVSALRRQVGMVFQRPNPFPKSIYENVVYGLRLQGINDRRTLDEAAERSLRGAALWDEVKDRLHDNAFGLSGGQQQRLVIARAIAIEPEVLLLDEPTSALDPISTLTIEELINELKSQFTVVIVTHNMQQAARVSDQTAFMYMGELIEYSDTNTIFTTPAKKKTEDYITGRYG
>NC_015424.1|WP_005350700.1|2890602_2892252_-|phosphate-ABC-transporter-permease-PstA
MGKWFKSGAPWIWMTGGAVSLSLVAVLGLLLLIGWRGLVYFWPHPIYEWQLEDASGNKSVLIGEINDREQVPVERLRAAGLALEGEDRELLTRYLVKTGNREFVDLDFRWVLETDIKSQSQPAELAMVERATNGNFYGYIVGVKEDGRELTSDLHPALQRVLARANALSEQANDLQKGDIGSINYQLERLRLKERKAELDDKLTDQLKAELASERQALNDRYQVLEKELFSLRSQADRDAITVKDMRGELVTMPMSKVLDVVWPNDMSLLAKVGHWFHQIGKFVSDDPREANTEGGVFPAIFGTVFMVFLMAIIVTPLGVVAAVYLHEYAGKNSLTKIIRIAVINLAGVPSIVYGVFGLGFFVYTLGGSLDQLFYPEALPSPTFGSPGVIWSALTLAILTLPVVIVSTEEGLARIPSTIRQGSLALGATQAETLWRIVLPMASPAIMTGLILAIARAAGEVAPLMLVGVVKLAPTLPMDGNFPYLHVERKFMHLGFHIYDVGFQSPNVEAARPLVYATSFLLVTVIVGLNLTAIGIRNHLREKFRSLEH

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Crispr_ID: NC_015424_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015424_5

3631276-3631371

Orphan

Consensus_repeat	Method
ACGACTTCCAGACCGAAACCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015424_5

>merge|NC_015424|5|3631276-3631371|CRISPRCasFinder
ACGACTTCCAGACCGAAACCACCCGGAAGGGAATGGTACTTCTCTGGTGGAACTTTACTCGCCGATGTACTCAACCACTTCCAGACCGAAACCACC

>NC_015424|5|5|3631276-3631371|CRISPRCasFinder
ACGACTTCCAGACCGAAACCACC	CGGAAGGGAATGGTACTTCTCTGGTGGAACTTTACTCGCCGATGTACTCA
ACCACTTCCAGACCGAAACCACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015424.1\|WP_005349514.1\|3623806_3624781_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_015424.1\|WP_005343514.1\|3630227_3630641_-\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|234686
NC_015424.1\|WP_013724073.1\|3626507_3628232_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NC_015424.1\|WP_005338866.1\|3630655_3631126_-\|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl\|CDD\|234606
NC_015424.1\|WP_005338880.1\|3634606_3635056_-\|transcriptional-regulator-NrdR	unknown	unknown	gnl\|CDD\|234774
NC_015424.1\|WP_005349498.1\|3641538_3642252_-\|two-component-system-response-regulator-TorR	unknown	unknown	gnl\|CDD\|182711
NC_015424.1\|WP_005349495.1\|3642397_3643564_+\|pentaheme-c-type-cytochrome-TorC	unknown	unknown	gnl\|CDD\|184992
NC_015424.1\|WP_026034998.1\|3629210_3630170_-\|thiamine-phosphate-kinase	unknown	unknown	gnl\|CDD\|235583
NC_015424.1\|WP_005349506.1\|3633297_3634407_-\|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	unknown	unknown	gnl\|CDD\|182729
NC_015424.1\|WP_005349507.1\|3632588_3633242_-\|riboflavin-synthase	unknown	unknown	gnl\|CDD\|236455
NC_015424.1\|WP_005338884.1\|3635206_3636460_-\|serine-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234571
NC_015424.1\|WP_005349499.1\|3641097_3641502_+\|GFA-family-protein	unknown	unknown	gnl\|CDD\|226314
NC_015424.1\|WP_005349515.1\|3622862_3623804_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_015424.1\|WP_005349505.1\|3636784_3637069_+\|hypothetical-protein	unknown	unknown	unknown
NC_015424.1\|WP_005349503.1\|3640013_3641060_+\|TMAO-reductase-system-periplasmic-protein-TorT	unknown	unknown	gnl\|CDD\|236801
NC_015424.1\|WP_005349509.1\|3628719_3629214_-\|phosphatidylglycerophosphatase-A	unknown	unknown	gnl\|CDD\|182942
NC_015424.1\|WP_005349513.1\|3624880_3626437_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173863
NC_015424.1\|WP_005349504.1\|3637117_3639943_-\|TMAO-reductase-system-sensor-histidine-kinase/response-regulator-TorS	unknown	unknown	gnl\|CDD\|274362
NC_015424.1\|WP_005335285.1\|3622519_3622735_+\|SlyX-family-protein	unknown	unknown	gnl\|CDD\|377222
NC_015424.1\|WP_005349516.1\|3621536_3622505_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121

Protein	Function_ID	Function_description	E-value
NC_015424.1\|WP_005349514.1\|3623806_3624781_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.78639e-112
NC_015424.1\|WP_005343514.1\|3630227_3630641_-\|transcription-antitermination-factor-NusB	gnl\|CDD\|234686	PRK00202, nusB, transcription antitermination factor NusB.	5.47456e-61
NC_015424.1\|WP_013724073.1\|3626507_3628232_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	0
NC_015424.1\|WP_005338866.1\|3630655_3631126_-\|6,7-dimethyl-8-ribityllumazine-synthase	gnl\|CDD\|234606	PRK00061, ribH, 6,7-dimethyl-8-ribityllumazine synthase; Provisional.	5.62066e-81
NC_015424.1\|WP_005338880.1\|3634606_3635056_-\|transcriptional-regulator-NrdR	gnl\|CDD\|234774	PRK00464, nrdR, transcriptional repressor NrdR.	5.30495e-93
NC_015424.1\|WP_005349498.1\|3641538_3642252_-\|two-component-system-response-regulator-TorR	gnl\|CDD\|182711	PRK10766, PRK10766, two-component system response regulator TorR.	9.31053e-134
NC_015424.1\|WP_005349495.1\|3642397_3643564_+\|pentaheme-c-type-cytochrome-TorC	gnl\|CDD\|184992	PRK15032, PRK15032, pentaheme c-type cytochrome TorC.	0
NC_015424.1\|WP_026034998.1\|3629210_3630170_-\|thiamine-phosphate-kinase	gnl\|CDD\|235583	PRK05731, PRK05731, thiamine monophosphate kinase; Provisional.	8.71727e-145
NC_015424.1\|WP_005349506.1\|3633297_3634407_-\|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	gnl\|CDD\|182729	PRK10786, ribD, bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD.	0
NC_015424.1\|WP_005349507.1\|3632588_3633242_-\|riboflavin-synthase	gnl\|CDD\|236455	PRK09289, PRK09289, riboflavin synthase.	2.99738e-113
NC_015424.1\|WP_005338884.1\|3635206_3636460_-\|serine-hydroxymethyltransferase	gnl\|CDD\|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0
NC_015424.1\|WP_005349499.1\|3641097_3641502_+\|GFA-family-protein	gnl\|CDD\|226314	COG3791, COG3791, Uncharacterized conserved protein [Function unknown].	2.72863e-28
NC_015424.1\|WP_005349515.1\|3622862_3623804_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.55821e-102
NC_015424.1\|WP_005349503.1\|3640013_3641060_+\|TMAO-reductase-system-periplasmic-protein-TorT	gnl\|CDD\|236801	PRK10936, PRK10936, TMAO reductase system periplasmic protein TorT; Provisional.	8.08954e-137
NC_015424.1\|WP_005349509.1\|3628719_3629214_-\|phosphatidylglycerophosphatase-A	gnl\|CDD\|182942	PRK11068, PRK11068, phosphatidylglycerophosphatase A; Provisional.	5.41283e-62
NC_015424.1\|WP_005349513.1\|3624880_3626437_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173863	cd08498, PBP2_NikA_DppA_OppA_like_2, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_015424.1\|WP_005349504.1\|3637117_3639943_-\|TMAO-reductase-system-sensor-histidine-kinase/response-regulator-TorS	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	0
NC_015424.1\|WP_005335285.1\|3622519_3622735_+\|SlyX-family-protein	gnl\|CDD\|377222	pfam04102, SlyX, SlyX. The SlyX protein has no known function. It is short less than 80 amino acids and is found close to the slyD gene. The SlyX protein has a conserved PPH(Y/W) motif at its C-terminus. The protein may be a coiled-coil structure.	1.14888e-21
NC_015424.1\|WP_005349516.1\|3621536_3622505_+\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	2.87266e-25

>NC_015424.1|WP_005338866.1|3630655_3631126_-|6,7-dimethyl-8-ribityllumazine-synthase
MKVIEGNIAAPEARVAIVVARFNSFINDSLVNGAVDVLKRQGQVQDSNLTLVKVPGAVEMPLVIKKLAKSGQYDAIVAVGTVIRGGTYHFDLVANENSKGMAQVMMEYEIPVAFGVLTTENIEQAIERAGTKAGNKGAEAALAALEMINVLKELDV
>NC_015424.1|WP_005343514.1|3630227_3630641_-|transcription-antitermination-factor-NusB
MKPSERRKARHCATQAIYQWQMTKANVGDIEEQFKIDQDTKGVDLNYFRDLLFGVALHCSELDKVFAPFLSRPLEEVDMVDKAILRLATYELTRRDDVPPRVVINEAIELAKAFAADDSHKFVNGVLDKVIKSLNKR
>NC_015424.1|WP_026034998.1|3629210_3630170_-|thiamine-phosphate-kinase
MGEFELIDKYFKVPHARKDVVMGPGDDCALLTLPPDTQLAVSTDTLVSGVHFFPDMDPVDLGYKALAVNLSDLAAMGAEPRWVSLALTLPAINEGWVAGFAEGFLELAEYYNVALVGGDMTRGPLSITISVKGSVPAGRALMRSGAKAGDGIYVTGTLGDAALALSHLLGKRTLNENQLAAVLPRLDHPHPRILAGQALRGLAGSALDLSDGLASDLGHILKASGVRAQIDLDLLPLSPVLQDAVSEQEAWQLALAGGDDYELCFTVPEEHRGALDTALAHSGVKFSRIGRIVAGEPGIDYLRGDQAVELQLKGWDHFA
>NC_015424.1|WP_005349509.1|3628719_3629214_-|phosphatidylglycerophosphatase-A
MSLFRIKPELTRLDLKNPLHFLAVGFGSGLSPKAPGTMGTLAAIPLYLLVSGLPTHWFIALLAVGFVVGIRICQSATDAIGMPDHGAIVWDEVIGFGVTMIAAPAGWEWVVAGFALFRLFDVLKPWPISWFDRRIHGGLGIMLDDLIAGLFALFCMQLLAFWLG
>NC_015424.1|WP_013724073.1|3626507_3628232_-|ABC-transporter-ATP-binding-protein
MSLLEVKNLRIEYPSRYGVLAAVKDLSFSIEKGEIVGVVGESGAGKSTIGNAVIDLLSPPGRIARGDIYLNGELISGKSQNEMRAIRGSRIGFIFQDPMTSLNPLFTVEHQLVETILANTDLSREATFAKALELMGAVGIPSPELRIKQYPHQFSGGMRQRVVIAIALSCDPELIIADEPTTALDVSIQDQILQLIRALCKERQVGCMLVTHDMGVVSNVTDKVAVMYRGDLVEFGLTEQVLGSPNHPYTRSLISAVPRSDVKLVRFPLVSYIEDASAPDTNIDLKTHWLGQSQDERAYEGALLRVENVDLKFVTKDSIFPSRRQYVRACNNISFEIFEGETFGLVGESGSGKSTIARAITGLYPPDTGKIFFEGIDLTALKSERERRPLRRQMQMVFQNPYSSMNPRMKVRDIIAEPIRFHQLASSESQIEGIVGDLLDHVGLGRGAGVKYPHEFSGGQRQRISIARALATRPRFLICDEPTSALDVSVQAQILNLLKDLQQELKLTMLFISHDLPVIRQMCDRIGVMQHGHLVEVAETEKLFTNAEHEYSRKLISLMPEFKGMSREGLEIAS
>NC_015424.1|WP_005349513.1|3624880_3626437_-|ABC-transporter-substrate-binding-protein
MKKGLSKIALALFAAGFAFSVSAADIKVGVASDATSLDPQEQLSGQTLEMSHLVFDPLMRYTQDLKFEPRLAEKFERVDDKTVRFHLRKGVKFHSGNDFTADDVVWTVNRLKSSVDFKAIFDPISEVKKVDDYTVDLITAKPFPLVLQTVTYIFPMDSKFYTGKTEAGKDKAEIVKNGDSYASTHVSGTGPFTVKFREQGVKLDYARNANYWDKASKGNVENLTVVPIKEDATRVAALLGGDVDMIYPVAPNDLERVKNGKDSQLVTLSGTRAIIIELNQNTNPALKDKRVRQAINYAINQVGIVEKINKGFGTPAGQLSPKGYAGHNEALVPQYDLAKAKELMKEAGYEKGFKMTFISPAARYVNDVKIAQAVSAMLAKINIKVDLKTMPVAQYWPEFDKCAADMQLIGWHSDTEDTANFFEFLTFTKDAKTGMGQYNCAGYANAEADKLVMDANAETDPAKRAEMLKKVEAMLIEDAAYVPLHWEDLAYGAKKNVDIKPVVNVMNFPYLGDLVVSK
>NC_015424.1|WP_005349514.1|3623806_3624781_-|ABC-transporter-permease
MFTFLLKRFYQAVIVMFVISLVAFSIQDNLGDPLRELVGQSVSEAQRHELREKMGLNDPFLIKYSRFLKNAVHGDLGTSYFFKRPALEVILDKLVATLELVFAAALIIVVVSIPLGVYSAIRPRSIPTKIIMAGSSIGISIPVFLTAIMLMYLFSIQLGWLPAYGRGETRNLLGWESGFFTWDGILHLILPAVSLSSIMLPLFIRLVRSEMLEQLSSEYVKFARAKGLDNNKVYYQHALKNTMLPVITVGGVQIGTMVAYTILTESVFQWPGTGFLFLEAIHRVDTPLITAYVIFVGLIFVVTNTLVDLLYGLINPTVNLTAKG
>NC_015424.1|WP_005349515.1|3622862_3623804_-|ABC-transporter-permease
MSNAVTASPSRWARFKNSDIVYYFLRDKVAMFSFAVFMVFVLAALLAPWLAPHNVYDQTSFDLMDAELPPSWLEGGEERFWLGTDNQGRDIWSTILYGARISLTIGLFAVALQLVLGIVIGLIAGYFGGRIDNLLMRFADVQLSFSTMMVAIIISAIFQATFGSEFYSKFAIMMLVVIIGIAEWPQYARTVRASVLAEKKKEYVEAAKVMGFRAPRIMFRHILPNCLSPILVISTVQVANAIMSEAALSFLGLGMPVDQPSLGSLISVGFNYIFSGSWWITAFPGICLVVLVLVINLLGDWLRDVFNPKIYKG
>NC_015424.1|WP_005335285.1|3622519_3622735_+|SlyX-family-protein
MSQQLNDRIETLETRLAYAEYTIEQLNDEVTTQGRELDRLKYQIQLLIDKLQSVQPSQIASMAEETPPPHY
>NC_015424.1|WP_005349516.1|3621536_3622505_+|hypothetical-protein
MIKSAIYLVSLCLMLTGCEQSSQPNQQMTLASTGLLTADLSSDGKQAIVSSISQGIIVWDLEQNRQRWRWKQSDSAEDLVFITRFSEGNSHAVTATPDTFATWRLNDGQSQGYYSLPESRLRDIALSADGRYVLIGREDGKAEWLDTRSGRRLQFLGHTEQVNTVDLSANGRYALTGGNDYSAYLWDTRSGQVIWRFNHGGRVIMARLEPSGRYAFTADSSRASIWDLKTGKEVSQLQYDHRFEVYTSARFANDGKWLITGAPSRQLSLWQVSDGALLQSWRVSPQPKVKPPSAVVYGVALRDNSHLVSASSSGLAEIWTIK
>NC_015424.1|WP_005349507.1|3632588_3633242_-|riboflavin-synthase
MFTGIIEAVGTLAELRRQGDDMALTVHAPGLDFSDVKLGDSIATNGVCLTVVALGDKSYTADVSLETLSRTGFAAARVGDRVNLEKALMPTSRLGGHLVSGHVDGVGEVKSVSSSGRAIEYWIKAPGELSRYIAEKGSIAVDGISLTVNAVQGDLFRLTIVPHTAQETTIASWKPGHKVNLEVDQIARYLERLMMGKSQESSASTLTMETLAKAGFL
>NC_015424.1|WP_005349506.1|3633297_3634407_-|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD
MFSQDDYQWMSRALELARRGRYTTAPNPCVGAVLVKDGVVVGEGWHQKAGEPHAEVYALRAAGDNARGATAYVTLEPCSHHGRTPPCAEALINAGVARVVAAMVDPNPQVGGRGLRMLSEAGIKTDFGLLASEAEALNPGFFKRMRTAFPRVTVKLGASLDGRTAMASGESQWITSPDARRDVQRLRARHDAVLSSAETVLADGASLTVRWDELPPSVKVSYPKETLRQPLRVIVDSQNRLTPELPLFQNESPVLLARHKASGEWPEWVQQLELPLLDGKLDLVSLFMLLAKQNVNSVLVEAGPRLCGALLEKGLVDELVLYQAPKLMGDEGRGLFHLPGLTRLFQAPKLAIKDVRMVGQDIRITAKIA
>NC_015424.1|WP_005338880.1|3634606_3635056_-|transcriptional-regulator-NrdR
MHCPFCSAVDTKVIDSRLVAEGHQVRRRRECLLCHERFTTFEMAELVMPRVIKSNGSREPFNEDKLRAGILRALEKRPVSMEAIEKAVNHIKSRLRATGEREVASELVGNLVMDELKSLDKVAYIRFASVYRSFEDIREFGEEIAKLEK
>NC_015424.1|WP_005338884.1|3635206_3636460_-|serine-hydroxymethyltransferase
MLKRDMTIANYDPQLWQAITDETRRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPSKRYYGGCEYVDVVETLAIERAKELFGATYANVQPHSGSQANSAVYMALLQPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDESGKIDYDDMERQAVEHKPKMMIGGFSAYSGIVDWARMREIADKVGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTSTTHKTLAGPRGGLILSAADDEELYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKTYQAQVVKNAKAMAATFIERGYKIVSGGTDNHLMLVDLIGRELTGKDADAALGKANITVNKNSVPNDPRSPFVTSGVRIGTPAITRRGFKEAESIELTHWICDVLDNHDNDAVLATVREKVLDICRRFPVYG
>NC_015424.1|WP_005349505.1|3636784_3637069_+|hypothetical-protein
MDHLLTFVILAVFFLFYWVYYTSQRKHLPTTSWEQLPTKAEYLATHPESVDGDIIFCYHCGHHELLELGMVHLTDFRREWVCAKCKQVLFREIE
>NC_015424.1|WP_005349504.1|3637117_3639943_-|TMAO-reductase-system-sensor-histidine-kinase/response-regulator-TorS
MRIFSGLGGKLLLAFSLMALLTLSASLLGWVGLSHLRQLEQGVQQTLADQELARTLSRLSGEIQSASRLLATATSEQEREHQGRLLTLQGQQLQQVLAQLGRGQGSTSLDQLSQSIIGNLGQQGWLVGERLTLMAQGEAQRARLVAAAGQIAELARSQMENAETVMVAGLGSLYQQQGAQATRTLDRLLEQDLDWLEQMTELRHRTLMQQQRIEEMWRSERQEQLQTLLQEGQRELAILQLRAGAVTDPARRQAVEQALTVLAQSDKLVQLRSDWLGKGEALRVLANANEALMSSLNQQVGELVSRARDSLGQSQQALSQRLRLLEQALMAIGLLTLLLLMLLMWRMVYGRIVWPLQRAVAGMSRLARGDLAPLEPIASTGRDELAELGRALQVFRDNAVELGRYQRELESRVEERTGQLSHANERLNEEVEKQRQARAEAEQANRAKSVFLATMSHEIRTPMNGILGGLTLLEDTHLSDTQQRYLAAIEHSGESLLEILNDILDYSKIEAGHVEARREPFPLFQLVDELGALFRPKAEAKGVTLALEYAPWLAPVVEGDLGKLRQVLGNLLGNAVKFTARGQITLTVAPLVCHGPCAEPCIRFVVRDTGPGIPADEQEAVFEAFRQRKRDIGHQGGTGLGLAISRKLVTAMGGELILASEPGKGCEFSFSLPLQRSSAQLPAEAQPLHLGQSRDILLVEDNEINRLVAHGMLTRLGHRVTLAEDGRSALALVTERPFELALLDINLPDMDGMSLREDLAAISEEMHERPLPAIAISAQMYPEDIRHCLAAGFVDFVGKPVRLAVLANAIDQLFRQEGTSIEPRVPLSVAVPPTNHPEWANPVLDADLPLLGMARIRQLVALFESQGRVLVDKLAQGEGKEQRQLAHKLKGSALALGLTEFASHCAALEAGGGEPAAIGGQFDAAVSGLQQWLAANRDSPF
>NC_015424.1|WP_005349503.1|3640013_3641060_+|TMAO-reductase-system-periplasmic-protein-TorT
MRSVYLSPLLLIWLLMLPRAALAFAVDIWPGGEFSGQPLRQQWPEPAAATKPLTLCALYPHLRDAYWLSVNQGMVDEAKRLGVKLQIHEAGGYGALAEQRQQLQRCVQEGSDAILLGAVSYQGLREAIKATPLPLFGLVNDLPNGLVQAKVGVSWYQMGWQIGHWLAQRHPAGSKPVSVALFPGPQASGGNNFVEPGFADAIKGSAIKLVSTERGDNSREIQRTLVQQTLARYPDLDYLVGGAIAAEVAVNELAQRHLDRPQVLSTYFSHGVQRGLRRGKILAANSDQMRLQGRLAVAQAVCLLQHPDANAEQCPRVMGPPILTLSAPLADPADSLSDGAFRPVYRVE
>NC_015424.1|WP_005349499.1|3641097_3641502_+|GFA-family-protein
MKELHASCLCGAVALTLPDQFDYMGNCHCSECRKFSGGDYASVGGLDGNKVTIVKGEEAIARYRKSAETTLAFCRHCGSSLFSQKSSSGKINLRLGVLDDVPSQRPAFHIFVGSKAPWHQIGDDCPQFDTRPPV
>NC_015424.1|WP_005349498.1|3641538_3642252_-|two-component-system-response-regulator-TorR
MSYHILVVEDDAVTREKLTGYFEREGYRVTAVENGQEMRAVLAEQPVDLVMLDINLPGEDGLLLTRELRARSTVGIILVTGRSDAVDRIVGLEMGADDYVTKPFELRELLVRVKNLLWRISLAAAAPSEPAVADDAVRFGPWRFDIPRRQLSKDGVPVRLTKAEYEVLVAFVAHAGRVLSRERILTLISHRGDGPSDRTIDVLIRRLRGKMEADPRDPQLFVTVHGEGYLFAGEIAS
>NC_015424.1|WP_005349495.1|3642397_3643564_+|pentaheme-c-type-cytochrome-TorC
MMKKLWHFLRTPSRRWSVLALLLVGVGVTLAGTVGLHYGFEKTSSLEFCISCHSMKDTVYPEYKESIHFKNASGVQAVCTDCHQPKDFVGKVARKIEAANDLYQEYIGHSIDTQEKFEDRRLHLAEKVWARMSSQNSKTCKSCHSYDNMDHAKQSPAAALAMKDAAAKNMNCIECHKGIAHELPNMAGGFRATYATLVNDAQEAPATETLYNLGEKDLYASEQSSEPVGKLLPASRIDVVDRSGDRLKVTIEGWRESDGKGRVLSEYMGKRVFVATIRDELKASEKVLKQETDSATHIKWEQVQVQAWVDGKGFESSLKPIWDYAGEMYKSTCNSCHGAPDPAHFTANGWISGLKAMSAYYRLSKEEERTLLKYLQNHAADTGGQGSH

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1987077 : 1993275

Shigella_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013723697.1\|1987077_1987374_+	hypothetical protein	A0A0C4UR00	Shigella_phage	1.1e-16	57.0
WP_013723698.1\|1987388_1987964_+	DUF3486 family protein	A0A0C4UQU5	Shigella_phage	3.6e-61	68.9
WP_013723699.1\|1987963_1989532_+	hypothetical protein	A0A2I7S9C5	Vibrio_phage	3.4e-162	59.5
WP_013723700.1\|1989531_1991115_+	DUF935 domain-containing protein	J9SVY0	Pseudomonas_phage	1.1e-131	51.0
WP_013723701.1\|1991114_1992602_+	hypothetical protein	A0A2H4IYU7	uncultured_Caudovirales_phage	2.0e-63	53.2
WP_013723702.1\|1992637_1992838_+	hypothetical protein	NA	NA	NA	NA
WP_013723703.1\|1992837_1993275_+	phage virion morphogenesis protein	Q5ZQY1	Pseudomonas_phage	1.9e-14	45.9

DBSCAN-SWA_2

2323741 : 2329113

Aeromonas_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005351639.1\|2323741_2324449_+	GGDEF domain-containing protein	A0A127AWB9	Bacillus_phage	5.3e-14	31.6
WP_005351638.1\|2324494_2325193_-	hypothetical protein	A0A1I9KFB9	Aeromonas_phage	1.3e-76	69.0
WP_005351637.1\|2325189_2325615_-	hypothetical protein	A0A1I9KG18	Aeromonas_phage	7.0e-54	69.5
WP_005351636.1\|2325611_2325941_-	DUF1364 family protein	A0A1B1ITP8	uncultured_Mediterranean_phage	3.0e-12	43.4
WP_005351635.1\|2325937_2326525_-	DUF1367 family protein	H6WRY7	Salmonella_phage	2.8e-45	44.9
WP_005351632.1\|2326839_2327094_-	hypothetical protein	NA	NA	NA	NA
WP_013723789.1\|2327472_2329113_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	3.7e-26	36.0

DBSCAN-SWA_3

2575433 : 2586016

Bacillus_phage(42.86%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005351207.1\|2575433_2576681_+	diguanylate cyclase	A0A127AWB9	Bacillus_phage	2.5e-14	32.2
WP_005337104.1\|2576789_2577260_-	glycine zipper 2TM domain-containing protein	NA	NA	NA	NA
WP_005351205.1\|2577279_2577987_+\|tRNA	leucyl/phenylalanyl-tRNA--protein transferase	NA	NA	NA	NA
WP_005351203.1\|2577983_2578700_+	arginyltransferase	NA	NA	NA	NA
WP_005300033.1\|2578768_2578987_+	translation initiation factor IF-1	NA	NA	NA	NA
WP_005351201.1\|2579055_2581311_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	3.5e-168	43.0
WP_005337111.1\|2581370_2581688_-\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	1.4e-14	49.4
WP_005300025.1\|2581917_2582136_+	cold shock-like protein CspD	A0A2H4N7Y6	Lake_Baikal_phage	1.2e-17	63.2
WP_005351199.1\|2582252_2583107_-	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	4.6e-28	32.9
WP_005351197.1\|2583958_2584669_+	two-component system response regulator RstA	W8CYM9	Bacillus_phage	2.5e-27	31.0
WP_005351190.1\|2584690_2586016_+	two-component system sensor histidine kinase RstB	W8CYF6	Bacillus_phage	2.3e-18	24.9

DBSCAN-SWA_4

2737544 : 2807899

Aeromonas_virus(15.79%)

portal,head,plate,capsid,integrase,tail,holin,terminase,protease,lysis,tRNA

attL 2751730:2751748|attR 2791990:2792008

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005350938.1\|2737544_2738921_-\|tRNA	cysteine--tRNA ligase	H2EDD6	Moumouvirus	9.3e-47	33.1
WP_005337417.1\|2739133_2739631_+	peptidylprolyl isomerase	NA	NA	NA	NA
WP_005350937.1\|2739620_2740418_+	DUF4269 domain-containing protein	NA	NA	NA	NA
WP_005350936.1\|2740414_2741170_+	UDP-2,3-diacylglucosamine diphosphatase	NA	NA	NA	NA
WP_005350934.1\|2741467_2744902_+	hypothetical protein	NA	NA	NA	NA
WP_005350931.1\|2745160_2745337_+	DUF3606 domain-containing protein	NA	NA	NA	NA
WP_005350930.1\|2745585_2745834_+	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_080559468.1\|2745900_2747256_-	sensor histidine kinase	NA	NA	NA	NA
WP_005350926.1\|2747299_2747974_-	transcriptional regulator TctD	NA	NA	NA	NA
WP_005350924.1\|2748196_2749183_+	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_005350923.1\|2749194_2749626_+	tripartite tricarboxylate transporter TctB family protein	NA	NA	NA	NA
WP_005350920.1\|2749635_2751168_+	tripartite tricarboxylate transporter permease	NA	NA	NA	NA
WP_005350918.1\|2751350_2751554_+	hypothetical protein	NA	NA	NA	NA
2751730:2751748	attL	NA	NA	NA	NA
WP_041915412.1\|2751751_2752114_-	hypothetical protein	NA	NA	NA	NA
WP_041915413.1\|2752144_2753200_-\|integrase	tyrosine-type recombinase/integrase	A5X9F3	Aeromonas_virus	9.1e-111	58.3
WP_013723851.1\|2753260_2755048_-	DUF4209 domain-containing protein	NA	NA	NA	NA
WP_013723852.1\|2755103_2755574_-	hypothetical protein	NA	NA	NA	NA
WP_041915414.1\|2755601_2756300_-	helix-turn-helix domain-containing protein	A0A1I9KG86	Aeromonas_phage	2.9e-44	40.8
WP_041915415.1\|2756418_2756607_+	helix-turn-helix domain-containing protein	A5VW97	Enterobacteria_phage	3.9e-09	56.4
WP_013723854.1\|2756628_2756898_+	hypothetical protein	Q1I116	Pasteurella_virus	4.8e-08	44.1
WP_013723855.1\|2756890_2757400_+	phage regulatory CII family protein	A5X9F7	Aeromonas_virus	7.1e-45	54.3
WP_005351998.1\|2757408_2757633_+	ogr/Delta-like zinc finger family protein	E5E3T8	Burkholderia_phage	1.1e-10	48.5
WP_013723856.1\|2757682_2758135_+	hypothetical protein	A5X9F8	Aeromonas_virus	3.7e-37	55.0
WP_013723857.1\|2758200_2758389_+	hypothetical protein	NA	NA	NA	NA
WP_005352009.1\|2758391_2758652_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_005352017.1\|2758845_2759052_+	hypothetical protein	A5X9G1	Aeromonas_virus	2.1e-16	68.2
WP_005352019.1\|2759048_2759249_+	hypothetical protein	NA	NA	NA	NA
WP_041915416.1\|2759226_2759538_+	hypothetical protein	A5X9G2	Aeromonas_virus	1.3e-28	64.7
WP_005352024.1\|2759534_2759792_+	hypothetical protein	NA	NA	NA	NA
WP_013723860.1\|2759788_2762029_+	replication endonuclease	A5X9G4	Aeromonas_virus	0.0e+00	77.4
WP_013723861.1\|2762291_2763641_-	hypothetical protein	NA	NA	NA	NA
WP_013723862.1\|2763990_2765268_-	translesion error-prone DNA polymerase V subunit UmuC	F1C5A5	Cronobacter_phage	7.3e-131	56.8
WP_041915443.1\|2765264_2765663_-	translesion error-prone DNA polymerase V autoproteolytic subunit	A0A1W6JNS2	Morganella_phage	1.7e-30	51.7
WP_013723864.1\|2766732_2767740_+	DUF4062 domain-containing protein	NA	NA	NA	NA
WP_013723865.1\|2768196_2769201_-\|portal	phage portal protein	A0A1S6KZW5	Salmonella_phage	9.0e-108	56.2
WP_013723866.1\|2769200_2770967_-\|terminase	terminase ATPase subunit family protein	A0A1S6KZW3	Salmonella_phage	1.5e-238	68.9
WP_013723867.1\|2771116_2771920_+\|capsid	GPO family capsid scaffolding protein	F1BUR1	Erwinia_phage	4.3e-60	46.6
WP_013723868.1\|2771932_2772991_+\|capsid	phage major capsid protein, P2 family	A4JWP9	Burkholderia_virus	5.5e-108	57.4
WP_013723869.1\|2773000_2773762_+\|terminase	terminase	A4PE31	Ralstonia_virus	2.6e-43	45.3
WP_013723870.1\|2773870_2774347_+\|head	head completion/stabilization protein	E5E3S2	Burkholderia_phage	1.4e-31	51.3
WP_013723871.1\|2774346_2774550_+\|tail	tail protein X	A0A2H4J946	uncultured_Caudovirales_phage	2.0e-14	57.6
WP_013723872.1\|2774578_2774809_+	TraR/DksA C4-type zinc finger protein	U3PFL5	Vibrio_phage	1.1e-05	39.1
WP_005352066.1\|2774818_2775190_+	membrane protein	NA	NA	NA	NA
WP_013723873.1\|2775186_2775528_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_013723874.1\|2775524_2776346_+	DUF3380 domain-containing protein	A0A2H4JGJ9	uncultured_Caudovirales_phage	3.3e-68	52.3
WP_013723875.1\|2776335_2776809_+\|lysis	phage lysis regulatory protein LysB	A0A1S6KZX8	Salmonella_phage	6.5e-08	33.8
WP_013723876.1\|2776916_2777387_+\|tail	phage tail protein	A0A077K8R3	Ralstonia_phage	2.9e-32	50.4
WP_013723877.1\|2777368_2777821_+	phage virion morphogenesis protein	Q6K1H7	Salmonella_virus	6.2e-24	43.8
WP_049790229.1\|2777894_2778656_+	hypothetical protein	NA	NA	NA	NA
WP_143231919.1\|2778818_2779985_+	hypothetical protein	NA	NA	NA	NA
WP_013723880.1\|2780080_2780632_+\|plate	phage baseplate assembly protein V	F1BUP5	Erwinia_phage	1.0e-25	40.1
WP_013723881.1\|2780628_2780988_+	GPW/gp25 family protein	O80315	Escherichia_phage	7.8e-22	49.5
WP_013723882.1\|2780984_2781866_+\|plate	baseplate J/gp47 family protein	A0A218M4K5	Erwinia_phage	6.1e-68	51.2
WP_013723883.1\|2781876_2782278_+	hypothetical protein	A0A0U1UNR7	Pseudomonas_phage	1.9e-29	51.9
WP_013723884.1\|2782277_2783693_+\|tail	phage tail protein I	A4JWL7	Burkholderia_virus	3.5e-33	44.2
WP_013723885.1\|2783694_2784897_+	hypothetical protein	A0A1B0XUH9	Freshwater_phage	7.1e-27	68.4
WP_013723886.1\|2784906_2785314_+\|tail	tail fiber assembly protein	NA	NA	NA	NA
WP_013723887.1\|2785508_2786687_+\|tail	phage tail sheath protein	F1BUU3	Erwinia_phage	3.8e-134	62.3
WP_013723888.1\|2786696_2787215_+\|tail	phage major tail tube protein	E5G6P8	Salmonella_phage	1.3e-49	56.4
WP_013723889.1\|2787292_2787577_+\|tail	phage tail assembly protein	R4JJY8	Burkholderia_phage	2.9e-19	56.5
WP_041202707.1\|2787585_2787717_+\|tail	GpE family phage tail protein	NA	NA	NA	NA
WP_013723890.1\|2787713_2790149_+\|tail	phage tail tape measure protein	A0A2H4JE61	uncultured_Caudovirales_phage	2.5e-127	42.5
WP_013723891.1\|2790161_2790653_+\|tail	phage tail protein	E5G6Q2	Salmonella_phage	7.1e-34	50.0
WP_013723892.1\|2790652_2791813_+	phage late control D family protein	A0A0M5M5V5	Salmonella_phage	7.4e-98	49.6
WP_005337443.1\|2792561_2793116_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
2791990:2792008	attR	NA	NA	NA	NA
WP_005350898.1\|2793315_2795169_-	excinuclease ABC subunit UvrC	NA	NA	NA	NA
WP_005337448.1\|2795296_2795941_-	UvrY/SirA/GacA family response regulator transcription factor	NA	NA	NA	NA
WP_013723894.1\|2796153_2796903_-	3-deoxy-manno-octulosonate cytidylyltransferase	NA	NA	NA	NA
WP_005347033.1\|2796899_2797088_-	hypothetical protein	NA	NA	NA	NA
WP_013723895.1\|2797211_2798207_-	tetraacyldisaccharide 4'-kinase	NA	NA	NA	NA
WP_005359702.1\|2798206_2799970_-	lipid A ABC transporter ATP-binding protein/permease MsbA	W8CYL7	Bacillus_phage	2.2e-56	30.7
WP_013723896.1\|2800074_2802276_-	DNA internalization-related competence protein ComEC/Rec2	NA	NA	NA	NA
WP_005350890.1\|2802303_2802822_+	DUF2062 domain-containing protein	NA	NA	NA	NA
WP_005350889.1\|2802815_2803319_+	DUF2062 domain-containing protein	NA	NA	NA	NA
WP_005350888.1\|2803425_2804616_-	aspartate/tyrosine/aromatic aminotransferase	NA	NA	NA	NA
WP_005350886.1\|2804761_2805703_-	hypothetical protein	NA	NA	NA	NA
WP_005337525.1\|2805874_2806747_-	HTH-type transcriptional regulator HdfR	NA	NA	NA	NA
WP_005350885.1\|2806746_2807118_-	DUF413 domain-containing protein	NA	NA	NA	NA
WP_005337529.1\|2807416_2807899_-\|protease	serine protease inhibitor ecotin	NA	NA	NA	NA

DBSCAN-SWA_5

3630655 : 3639943

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005338866.1\|3630655_3631126_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.1e-29	47.3
WP_005349508.1\|3631329_3632439_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	3.9e-64	39.2
WP_005349507.1\|3632588_3633242_-	riboflavin synthase	A0A1V0SE20	Indivirus	2.7e-20	37.8
WP_005349506.1\|3633297_3634407_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	1.4e-48	34.7
WP_005338880.1\|3634606_3635056_-	transcriptional regulator NrdR	NA	NA	NA	NA
WP_005338884.1\|3635206_3636460_-	serine hydroxymethyltransferase	A0A219Y950	Aeromonas_phage	3.9e-100	53.2
WP_005349505.1\|3636784_3637069_+	hypothetical protein	NA	NA	NA	NA
WP_005349504.1\|3637117_3639943_-	TMAO reductase system sensor histidine kinase/response regulator TorS	A0A1V0SGX0	Hokovirus	6.1e-45	31.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_015424

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection