CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015125	Microbacterium testaceum StLB037, complete genome	19 crisprs	WYL,csa3,DEDDh,cas3	0	13	1	0

1. NC_015125

CRISPR-Cas detection and classification

Crispr_ID: NC_015125_1

• CRISPR_ID: NC_015125_1
• CRISPR_location: 185026-185128
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_1

Consensus_repeat	Method
CCACCGCGCCCCAGGTCCCTGAGCCCGTCGAAGGGACCG	CRISPRCasFinder

spacers of NC_015125_1

>1.1|185065|25|NC_015125|CRISPRCasFinder
CAGGCTTCCACACGCTCAGCCACCC

CRISPR arrays and Neighbor proteins around NC_015125_1

CRISPR arrays

The CRISPR arrays of NC_015125_1

>merge|NC_015125|1|185026-185128|CRISPRCasFinder
CCACCGCGCCCCAGGTCCCTGAGCCCGTCGAAGGGACCGCAGGCTTCCACACGCTCAGCCACCCCCACCGCACCCCAGGTCCCTGAGCCCGTCGAAGGGACCG

>NC_015125|1|1|185026-185128|CRISPRCasFinder
CCACCGCGCCCCAGGTCCCTGAGCCCGTCGAAGGGACCG	CAGGCTTCCACACGCTCAGCCACCC
CCACCGCACCCCAGGTCCCTGAGCCCGTCGAAGGGACCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013583272.1|181403_182600_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380556
NC_015125.1|WP_013583274.1|185268_185985_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|378924
NC_015125.1|WP_013583281.1|192401_193436_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl|CDD|182463
NC_015125.1|WP_013583263.1|174977_175310_+|phenylalanyl-tRNA-synthetase-subunit-beta	unknown	unknown	unknown
NC_015125.1|WP_013583262.1|174695_174956_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_043360836.1|188646_189366_+|two-pore-domain-potassium-channel-family-protein	unknown	unknown	gnl|CDD|369572
NC_015125.1|WP_148272778.1|189489_190233_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013583273.1|182757_184992_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226418
NC_015125.1|WP_013583264.1|175332_175881_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013583275.1|185981_187448_+|aldehyde-dehydrogenase	unknown	unknown	gnl|CDD|365919
NC_015125.1|WP_013583276.1|187444_188569_+|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|176239
NC_015125.1|WP_043360840.1|194273_195095_+|siderophore-interacting-protein	unknown	unknown	gnl|CDD|99790
NC_015125.1|WP_043361795.1|179935_180610_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|223487
NC_015125.1|WP_013583269.1|178992_179847_-|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|119324
NC_015125.1|WP_013583280.1|191358_192405_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl|CDD|182464
NC_015125.1|WP_043361796.1|180609_181398_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213186
NC_015125.1|WP_013583279.1|190432_191362_+|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238566
NC_015125.1|WP_013583267.1|176919_177885_+|polyketide-synthase	unknown	unknown	unknown
NC_015125.1|WP_013583282.1|193428_194262_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224045
NC_015125.1|WP_013583268.1|178018_178996_-|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|119323

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013583272.1|181403_182600_-|ABC-transporter-substrate-binding-protein	gnl|CDD|380556	cd06333, PBP1_ABC_RPA1789-like, type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, RPA1791-1793), involved in active transport of lignin-derived aromatic substrates, and its close homologs. This group includes RPA1789 (CouP) from Rhodopseudomonas palustris and its close homologs in other bacteria. RPA1789 (CouP) is the periplasmic binding-protein component of an ABC system (CouPSTU; RPA1789, RPA1791-1793) that is involved in the active transport of lignin-derived aromatic substrates. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).	6.70334e-94
NC_015125.1|WP_013583274.1|185268_185985_+|alpha/beta-hydrolase	gnl|CDD|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	2.74794e-12
NC_015125.1|WP_013583281.1|192401_193436_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl|CDD|182463	PRK10440, PRK10440, iron-enterobactin ABC transporter permease.	3.02381e-90
NC_015125.1|WP_043360836.1|188646_189366_+|two-pore-domain-potassium-channel-family-protein	gnl|CDD|369572	pfam07885, Ion_trans_2, Ion channel. This family includes the two membrane helix type ion channels found in bacteria.	5.00957e-14
NC_015125.1|WP_013583280.1|191358_192405_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl|CDD|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	1.14865e-95
NC_015125.1|WP_013583273.1|182757_184992_+|AAA-family-ATPase	gnl|CDD|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	6.8871e-50
NC_015125.1|WP_013583275.1|185981_187448_+|aldehyde-dehydrogenase	gnl|CDD|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	0
NC_015125.1|WP_043360840.1|194273_195095_+|siderophore-interacting-protein	gnl|CDD|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	8.78966e-65
NC_015125.1|WP_043361795.1|179935_180610_-|ABC-transporter-ATP-binding-protein	gnl|CDD|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	1.04114e-87
NC_015125.1|WP_013583269.1|178992_179847_-|branched-chain-amino-acid-ABC-transporter-permease	gnl|CDD|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	1.43296e-49
NC_015125.1|WP_043361796.1|180609_181398_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	2.03026e-108
NC_015125.1|WP_013583279.1|190432_191362_+|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl|CDD|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	2.4942e-63
NC_015125.1|WP_013583276.1|187444_188569_+|NAD(P)-dependent-alcohol-dehydrogenase	gnl|CDD|176239	cd08278, benzyl_alcohol_DH, Benzyl alcohol dehydrogenase. Benzyl alcohol dehydrogenase is similar to liver alcohol dehydrogenase, but has some amino acid substitutions near the active site, which may determine the enzyme's specificity of oxidizing aromatic substrates. Also known as aryl-alcohol dehydrogenases, they catalyze the conversion of an aromatic alcohol + NAD+ to an aromatic aldehyde + NADH + H+. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	5.37007e-160
NC_015125.1|WP_013583282.1|193428_194262_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	5.48292e-131
NC_015125.1|WP_013583268.1|178018_178996_-|branched-chain-amino-acid-ABC-transporter-permease	gnl|CDD|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	1.28816e-54

Protein sequences

>NC_015125.1|WP_013583273.1|182757_184992_+|AAA-family-ATPase
MIREPRSEFVGRRRELDALADALERTRLITLTGVGGVGKTRLAMRLANAHARRTSTTVYFVGLDAVSDPRRVVAAIAQSLPFGDLSARDPLEFVVDVLSDETALLVLDNCEHVIDAAASVVDELLDALPNVTIVATSRRRLDVDGEQVFPVPPLGTEAAGGEPAEAVELLLARARAADAGFTLAPAEVAVAEQLCLALDGLPLAIELAAGRLRTLSVSDLARRLSQRFTLLRAGSRAPVSRQRTLRAVVDWSYELCTPPERALWAALSVFAGPFDLPAAAAVAGGDEAVTVETLEQLIDQSLVEADRDSGRFHLLETIRGYGRDRAEESGEQHDLVRRHLEYYRGLARLARTHWYGPAQRRILAGQRADRAELDAALRTAAATDTDVALELFADLRYHWAVGGFLSEGRRWTRRLLRLPAASAASRTPALLVAAWICVLQGALDEARGHLDEARALLPSLPPADQERGEVELRRWSGTRALFAGESDLAREELSRSIRLARSLGRPEEALLAQFQLTVALVQSELPDTLEPARDAQHLAIEIGERWIRSLSLWAIGLALYAAGELDDAERHARDALAMEEGIDDPVGDCLVLELLSWIDAARSPTERTAVLLGAARSWWRRIDSGIAVHGPQMLAQHDRCVAVVRQRLGEEAFQRLSAVGERLSPAEAAAFAGAPGRPAAGLSARESEVAAGVHEGLSNREIAERLVLSVRTVDTHVQRILAKLGFTSRAQIAAWYRSTLVSVP
>NC_015125.1|WP_013583272.1|181403_182600_-|ABC-transporter-substrate-binding-protein
MRRTVPVVATAALVLALTACSGGGSTASGNGSGPVKIGMVVPLTGFLSALGQGDKEAAERVVADINSAGGIDGRQVELTVVDDKADVTESVKQFNQLASDPSYSAMLASSFVSAATAVGSTAQSARIPTIALGPVDAFADGSNPYAFTSPPIPAVYARALVDYWVSQGVKTLAIGYTGGDLYGTNGDKATAEYAKEAGIDVVLDESYDQTATDFTPLITKVVSAKPDAFVVWGAGPAPVIITKQIAGKGIATYFTGAEASDLYLQPAGDAAEGVKAAATIALGGDALPGGAYKTKVMAVAKPWMDANNGAYPPEFAFGGASGIELLAAAIDAADSTDRQKIRDALEKTDLLTSNGHYSYSPTDHMGLDATSLAIFEAKGGKWVPTDAATKQFATELPQ
>NC_015125.1|WP_043361796.1|180609_181398_-|ABC-transporter-ATP-binding-protein
MEPAESPSAGLELAGLSRRFGGVYANRDISFRIAPGELRGVIGPNGAGKSTLFGLISGHVRAQEGVIRLDGQRIDRLPPHRRAQRGIAIVFQGARLFPGMTVLENVAVGAHARTRSGALDAAVRSPRHRREEREIIADAEEALARVGLAEWAGRGAEQLPLGQQRRLQVARALTARPRVLLLDEPASGLRTDERDDLRGLIRELHDDGTTILLIEHDVAMVTALADRIAVLDLGRLIAEGTPDEIRRDPAVIAAYLGSEAAA
>NC_015125.1|WP_043361795.1|179935_180610_-|ABC-transporter-ATP-binding-protein
MLEVNDLVVRYGSATALDGVSLRVDAGELVALVGPNGAGKTSLVNAVSGLVRPASGTVRVEETVAQVPEGRQMFGDLSVDDNLRLGAWRRRSRRTDAVYELLPDLQRLRRQRADTLSGGQQQMVAVGRALMAEPDLLVVDELSLGLAPLIAADLVRHLAALNADRGTAVLLIEQEVGLAFGLCSRAYVLDAGRIVAEGPTAELAAAPEVRAAYLGGFDEQENPS
>NC_015125.1|WP_013583269.1|178992_179847_-|branched-chain-amino-acid-ABC-transporter-permease
MSDLATYLLSGLALAGSFALVGSGIVVVYRVTHVLNFAQGSFVVFGAFLSQTFRQLGLPPGLSELAAVVVVGLIGLVVGAVAIGKPGTHPMTSLLITLGMSLVAAAAIIAVWGQNPVSPAGIGGTVQLFGAEIETQRLVTLAVAVATLGAMSLLFTRTDIGRALTAAASNPRAARLVGIDTRAMGLLSFTIAGVLGGLAGVLIAPTTAVSVTSDLPFVLSALAAAVFGGLRSPWMTFVGALVLGVTGQLVAGYANGSYQTQIALIMMLAIMIARSRSFTAEEAK
>NC_015125.1|WP_013583268.1|178018_178996_-|branched-chain-amino-acid-ABC-transporter-permease
MTRIVIAVAAVVAAIAPLLLTDQTFFVQTALTALVVTGLSLFMGYAGQASLGQGAFVAVGGLTVAVGTVTLGIPPLLALIVAPVLGALVAALVGWPLLRLRGHYLAFGSLAVLLIIQTVMATAPLFGAGVGIFGIPPLSVAGFVVPDQRVYSYVALAALAAALVVCHNLVRSRFGRGIRALAGSESAAASSGVPILRSKLTVFAVAGGFAGFAGALGAFFTPYVSQDTYPPFASFGYVVMAVVGGLGSVWGGVVGTLALSLWLQVLSALSATPGMPAAAGPILQYAGYGIVLVVFLLFVPRGIVPTLAGLRGKRRAAPAMAVTRG
>NC_015125.1|WP_013583267.1|176919_177885_+|polyketide-synthase
MQELAGRLKVLDPAASESVKIIEYFDSLIAGGAGVEAVVRAAAILGGTTAGARVRGRLVGIDADGARTTPTPPPSLPDTDAPSVWLQRDTGAALNDAMIVDRAQVALAIITARADPTTSAVERVIDAGVSRVDREAAAHRLRLDGEVRVVAAPPHSRHVTTASTVLATADGAVWIGLGEVVPPDGPAGTSLARDLDDLPRACADARLALRLADERHRVVDAGELGVLIELARAVDPSGPRHPDLEVLDALDARTLEALDVVVDSESIRAAATRLSLHHSSLQSRHETWTRQLGYDPLTPRGRARFLAARMLQRLGSGTRES
>NC_015125.1|WP_013583264.1|175332_175881_-|hypothetical-protein
MGDLSGPEPGAAASEWVALLRAGDFAAAWQLTTDAFRLANAQAWITGHRGIVGMWPGKPKPDDLARALSQEHAEHELWPYLVREVERQVRGVVLGVLGERPIGTSTRPRPIAPDIELVHVIPLDQLTASADGVAMWQPGQVVDSVSILLQRASDEWRIAGVADHLPVPGWPPSFERVADLGD
>NC_015125.1|WP_013583263.1|174977_175310_+|phenylalanyl-tRNA-synthetase-subunit-beta
MGSNRRYARHYDRLMDQRILAQTAATAGPLQTLSPAELELDSEPVTIDPQPKPVRAWVRFGATPLRVDAEACRWTSRAVGIRFTVGQEQLQAWVWNSAVSERSPSTSTTA
>NC_015125.1|WP_013583262.1|174695_174956_-|hypothetical-protein
MAPTATDPTATLWLVDGTPTRLVYAGRRWRVTDTPTHLEGPGWSAPLEPHEPAAGWRLQATDTAGASFVFDVYRVGDAWHVHRSYG
>NC_015125.1|WP_013583274.1|185268_185985_+|alpha/beta-hydrolase
MTPSPPRILLVHGAWSGPWVFDRLAAQLGERGFAVDTVALPSIDSTADLYADAAAITAALDAAEGPLNLVAHSYGGAPTTQAGDHPAVERIVYVAAFALDEGETLQQAVGGGIPDFWGISDGMVSLGKSREERVAMIAADLPPGVPVALAEQLADTFRPQSLTAFTSPVTKVAWRTKPTTYVLTERDELVPPPLQEHFVARSGADVVRVDTGHTPFEDDPVWFAGVLADIITPAEVAR
>NC_015125.1|WP_013583275.1|185981_187448_+|aldehyde-dehydrogenase
MSLTVTTAPGRLFIDGRWADATDGGRMDVIAPSTGEKITDVARGTTADVDAAVAAARRAFDEGPWPRMSSRERARILQRAYALMRERSEELAAAESLDVGKPITFARVVDVNNAAELYEYYAALGHRLDGDVREIAADAHAYVRNEPLGVVAAITPFNFPLILSSTKIAPALVAGNTVVHKPASDTPLSALLMAELLRDAGVPDGVFNVVTGPGSTLGDHLVSHPDVDKVAFTGSTEIGAHAAALAGRTLKPFTAELGGNAANILFADADLDRAIHTVISAFVFNAGQFCMAGPRLLVERPIYGVVLGILKDAVPHVPFGDIDDPATVIGPVASRTQLDKVTAMVDRARAAGARVVTGGHAVERDGGFYYAPTVLADLDPDAEVVVDEVFGPVLTVQPFDTEDEAIALANGTKYGLASGIQTADLARAHRIAGRLRAGITWVNGWAILDPAVPFGGVKASGWGREGGPEALQSYQKAHSIVFDLGGAQ
>NC_015125.1|WP_013583276.1|187444_188569_+|NAD(P)-dependent-alcohol-dehydrogenase
MTAGRAAIVEEGRDGAALGTRTISVADVDYAEPGHGEVLVRLTATGLCHTDLGVLAGGIPFPTPGIIGHEGAGRVESVGPGVRGVSPGDAVLLSFTSCGACAACAGAHPAYCETWLPRNLLGGIREADSGGIARDGEPVAAHFFGQSSFGTYAIADERSLVRVADDADLAVLAPLGCGVLTGFGSMWNVLDPGPSDVVAVYGTGAVGLSAVMAAATRAPARLIAIDRVASRLDLARELGATDTIDAAHEDVAARLAELTDGRGVTLSFDTTGHPGVARSALDAAAARGTVLVCGAPPPGTEIPVDIQGILTGKILRGVTMGDADPRELIPRLVALHAEGRLPLEKLERQYALDDIAQAIDDMHHGRTVKPVIVY
>NC_015125.1|WP_043360836.1|188646_189366_+|two-pore-domain-potassium-channel-family-protein
MYGERLARWERTVEWPLVIAALLFLAAYAAQILATPEGVVETVAEVVLKATWALFLLDYVVRLAIAEHRWRWFWRHLLDLAIVALPVFRPLRLMRFFTIIALIQRNTGTMLRGRVALFTIGATALTVFVAALAVYDAEQRSGGPISTFGDAVWWAFETITTVGYGDYYPVTVTGRIVAVGLMVGGIALIGVVTATLASWIVQRVSVEAEEASAATETQVEALRGEIAELKQMLREAPRA
>NC_015125.1|WP_148272778.1|189489_190233_-|hypothetical-protein
MRRLSDGRAHIPLAGDARRLSVVQGVTIAIAAGLVLIVAVADDLGIRLLFGAFSLLLVAIAAYVGCLRRLLETGVVRIDTRGPGLRFRPPVWPTAFLVAILLLLALPAVAVVVIGDAGEALSPRRSPLLLPVFSAICLAVMIWRLRVPAGLRLTVDGIRGIRARGDLAWSWDEVGEVGVDGPPAALTLTMKDGYVPVTASMRYLGSDPNQVAAIVRFFRDHPEERAILARGGQAALDRAADALRPLD
>NC_015125.1|WP_013583279.1|190432_191362_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MPSHRSSRRLALLAAATGLALALSGCAGGADASLAESSASTHEVTHARGTTAVSTAPQRVVTLEPLELDTAVSVGITPVGAAVANMVNGVPSYLGVEGVTPVGTVSEPDLEAIAALKPDLILGTESRHSALYDQLSAIAPTVFIATQADPWRDNAALIGDALGREDDVKKAVDAVDQRCDEIKAAHDLAGKTAEMIRPRDETTLSLYGPVSFAGSLLECVGYTIPDHAWEDGLQADISPENIASATADAVFVTTADVNDPSTVPAAISQNAAAFPVVTLVDTSTWVAGVGPKGAQSVLDDIETFLASGK
>NC_015125.1|WP_013583280.1|191358_192405_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTSVVPPRVSDTAPGSPRIGRTAIGTLVLVAVLAVSVALSLMIGANPLPWHAVWASLTGAGTPDTDFVVLGLRVPRTIAGVVAGAALGVAGALMQAFSRNPLADPGILGVNAGAAFAVALTVALFGIQSSLLLIWPAFLGALVVTVAVALVGSSGRGPADPIRLTLAGVAVGAVLSGITSGMMLSNPDAFDLMRGWNAGSLLGRGLDIVLPVVPFIAAGLAVAFVLGRPLNALALGDDLARAQGIPVGAVRVASIAAITVLAAAATALVGPLSFVGLMVPHVVRWIVGPDQRRILPLSALAAPIVVLLADVLGRVIIAPAEVPAGIVTAFVGAPVLIALARRRRASTL
>NC_015125.1|WP_013583281.1|192401_193436_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTAVDVGYRRVHLGALPVRLRSIVVGAAVLAAVVVLAVLSLGWGTYPVAPDAVVRALLGAGDALDTTVVVGWRLPRVLAAVTLGALLAIAGALFQTVTRNPLASPDILGLSNGAFTGMLLTLVLVSASWPARAVGALIGCLVASVVIWFLSYRGGVQGFRLIVVGIGVSAMLASLNTWMLLQVELETAMFASAWGHGTLNGVTGEALGGVLLCAAPFALGAFALVRALRQLELGDDMAAASGVRPHLVRTLALLAGVVLVAAATAIAGPIAFVALAAPQIARRLARTPSLSLALSALVGALLLLGSDAVAQHLLPVTLPVGVVTVSVGGAYLIVMIVTEIRRRV
>NC_015125.1|WP_013583282.1|193428_194262_+|ABC-transporter-ATP-binding-protein
MSDPSRLEARSVSLAYDGTTVVPELSVAVPPGSFTVIIGPNACGKSTLLRGLSRLLAPAAGSVVLDGRDISSYPAKEVARRLGLLPQTALAPDGITVADLVGRGRYPHQSLLRQWSSADEIAVKEALDATGTADLSTRPVDALSGGQRQRVWVAMVLAQQTDLLLLDEPTTYLDVAHQVELMELFAELNARGRTVVAVLHDLNHAARYASHIIAMRDGRIVAEGAPREVITTERVEEVYGLPNVVIDDPVTGGPLVVPLRGGAFAARAAEAAAELDA
>NC_015125.1|WP_043360840.1|194273_195095_+|siderophore-interacting-protein
MPGAGTRPWEYSAFPVTVARREMISPSFLRLTFAGDALQHFAPWGVDQRIKLVLPLPDGGLADFGLLADPTPHPSAWYTRWKALPPDERNVLRTYTPAAIRPEAGEIDVDIYLHSPDGPASRWARGARVGETLVITGPDIRNGWTGYGIHWQPPEEYTSFLLVADETAIPAVRNIALSLPPTARGIAIVEIGDHADDVTVAGLSPQVDVRVVGRGKTEDAVRAWATPDVDVAWLAGESGVVTTSRRVLVREVGVPRERVAFLGYWREGGALVD

Crispr_ID: NC_015125_2

• CRISPR_ID: NC_015125_2
• CRISPR_location: 413151-413247
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_2

Consensus_repeat	Method
CGCCCCAGGTCCCTGAGCCCGTCGAAGGGACCG	CRISPRCasFinder

spacers of NC_015125_2

>2.1|413184|31|NC_015125|CRISPRCasFinder
TTTGCCACCCGCGAGCCATCCCCTCACATCA

CRISPR arrays and Neighbor proteins around NC_015125_2

CRISPR arrays

The CRISPR arrays of NC_015125_2

>merge|NC_015125|2|413151-413247|CRISPRCasFinder
CGCCCCAGGTCCCTGAGCCCGTCGAAGGGACCGTTTGCCACCCGCGAGCCATCCCCTCACATCACGCCCCAGGTCCCCGAGCCCGTCGAAGGGACCG

>NC_015125|2|2|413151-413247|CRISPRCasFinder
CGCCCCAGGTCCCTGAGCCCGTCGAAGGGACCG	TTTGCCACCCGCGAGCCATCCCCTCACATCA
CGCCCCAGGTCCCCGAGCCCGTCGAAGGGACCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013583497.1|417033_417807_-|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|223704
NC_015125.1|WP_013583484.1|403508_404471_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl|CDD|223619
NC_015125.1|WP_013583494.1|413808_414279_-|OsmC-family-protein	unknown	unknown	gnl|CDD|224678
NC_015125.1|WP_013583492.1|411538_413050_+|glycerol-kinase-GlpK	unknown	unknown	gnl|CDD|234594
NC_015125.1|WP_043361888.1|413292_413772_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013583487.1|406410_407049_+|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl|CDD|274099
NC_015125.1|WP_013583486.1|405418_406414_+|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl|CDD|237724
NC_015125.1|WP_013583495.1|414381_415365_+|asparaginase	unknown	unknown	gnl|CDD|377601
NC_015125.1|WP_013583488.1|407045_407768_+|HPr-family-phosphocarrier-protein	unknown	unknown	gnl|CDD|183108
NC_015125.1|WP_013583498.1|417925_418906_-|aldo/keto-reductase	unknown	unknown	gnl|CDD|223739
NC_015125.1|WP_013583499.1|418970_419681_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NC_015125.1|WP_013583502.1|420877_422326_-|F0F1-ATP-synthase-subunit-beta	unknown	unknown	gnl|CDD|236447
NC_015125.1|WP_013583490.1|408847_410566_+|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl|CDD|223651
NC_015125.1|WP_013583496.1|415455_416988_-|APC-family-permease	unknown	unknown	gnl|CDD|223605
NC_015125.1|WP_013583500.1|419794_420544_-|peroxide-stress-protein-YaaA	unknown	unknown	gnl|CDD|234999
NC_015125.1|WP_080575471.1|404630_405332_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NC_015125.1|WP_153004208.1|407774_408665_-|sugar-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|225263
NC_015125.1|WP_013583491.1|410687_411443_+|aquaporin-family-protein	unknown	unknown	gnl|CDD|223653
NC_015125.1|WP_013583501.1|420615_420876_-|F0F1-ATP-synthase-subunit-epsilon	unknown	unknown	gnl|CDD|184055
NC_015125.1|WP_013583483.1|402416_403499_-|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	unknown	unknown	gnl|CDD|235472

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013583497.1|417033_417807_-|serine/threonine-protein-phosphatase	gnl|CDD|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	8.22458e-66
NC_015125.1|WP_013583484.1|403508_404471_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl|CDD|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	5.05961e-27
NC_015125.1|WP_013583494.1|413808_414279_-|OsmC-family-protein	gnl|CDD|224678	COG1764, osmC, Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism].	1.19842e-16
NC_015125.1|WP_013583492.1|411538_413050_+|glycerol-kinase-GlpK	gnl|CDD|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NC_015125.1|WP_013583487.1|406410_407049_+|dihydroxyacetone-kinase-subunit-L	gnl|CDD|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	4.92492e-74
NC_015125.1|WP_013583486.1|405418_406414_+|dihydroxyacetone-kinase-subunit-DhaK	gnl|CDD|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
NC_015125.1|WP_013583495.1|414381_415365_+|asparaginase	gnl|CDD|377601	pfam06089, Asparaginase_II, L-asparaginase II. This family consists of several bacterial L-asparaginase II proteins. L-asparaginase (EC:3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartate and ammonium. Rhizobium etli possesses two asparaginases: asparaginase I, which is thermostable and constitutive, and asparaginase II, which is thermolabile, induced by asparagine and repressed by the carbon source.	4.52103e-126
NC_015125.1|WP_013583488.1|407045_407768_+|HPr-family-phosphocarrier-protein	gnl|CDD|183108	PRK11377, PRK11377, dihydroxyacetone kinase subunit M; Provisional.	1.60232e-51
NC_015125.1|WP_013583498.1|417925_418906_-|aldo/keto-reductase	gnl|CDD|223739	COG0667, Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion].	1.11347e-108
NC_015125.1|WP_013583499.1|418970_419681_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	1.58618e-05
NC_015125.1|WP_013583502.1|420877_422326_-|F0F1-ATP-synthase-subunit-beta	gnl|CDD|236447	PRK09280, PRK09280, F0F1 ATP synthase subunit beta; Validated.	0
NC_015125.1|WP_013583490.1|408847_410566_+|glycerol-3-phosphate-dehydrogenase/oxidase	gnl|CDD|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	5.30607e-128
NC_015125.1|WP_013583496.1|415455_416988_-|APC-family-permease	gnl|CDD|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	7.47682e-31
NC_015125.1|WP_013583500.1|419794_420544_-|peroxide-stress-protein-YaaA	gnl|CDD|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	4.62018e-48
NC_015125.1|WP_080575471.1|404630_405332_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	1.47232e-56
NC_015125.1|WP_153004208.1|407774_408665_-|sugar-binding-transcriptional-regulator	gnl|CDD|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	2.1523e-67
NC_015125.1|WP_013583491.1|410687_411443_+|aquaporin-family-protein	gnl|CDD|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	1.0925e-66
NC_015125.1|WP_013583501.1|420615_420876_-|F0F1-ATP-synthase-subunit-epsilon	gnl|CDD|184055	PRK13442, atpC, F0F1 ATP synthase subunit epsilon; Provisional.	4.27515e-28
NC_015125.1|WP_013583483.1|402416_403499_-|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	gnl|CDD|235472	PRK05447, PRK05447, 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional.	0

Protein sequences

>NC_015125.1|WP_013583492.1|411538_413050_+|glycerol-kinase-GlpK
MADYVLAIDQGTTSTRAMIFDKSGGVVAVGQKEHEQIFPRAGWVEHDPLEIWRNTQEVIGLALSRADITRHDIAAVGITNQRETAVVWDKNTGKPVYNAIVWQDTRTQSIVDRLADGDTERYKSIVGLPLATYFSGTKIVWILENVDGAREKAEAGDLIFGTTDTWVLWNLTGGIDGGVHATDVTNASRTLFMDLETLEWRDDILADFGVPRSMMPEIRSSSEVYGTVESSSLLRETPVAGILGDQQAATFGQAAFDPGESKNTYGTGNFLIFQTGEEIVHSKNGLLTTLGYKLGDQPARYALEGSIAVTGSLIQWLRDQLGIISSAPEVETLASSVDDNGGVYFVPAFSGLFAPYWRPDARGAIVGMTRYVNKGHIARAALEATAFQTREVLDAVNADSGVDLTELKVDGGMTANDALMQFQADILGVPVVRPVVAETTALGAAYAAGLAVGFWDNLDDLRANWQEDKRWEPDMDSDERDRELRLWKKAVTKSMDWVDEDVR
>NC_015125.1|WP_013583491.1|410687_411443_+|aquaporin-family-protein
MQEVNLGLYFLSEVVGTAMLILLGCGVVANVALAKTKGNAGGTLMVNWGWGLAVFAGVIVSAYSGAQLNPAVSIGLLVAGKIGFVQFLVAIAAQMVGAIIGAVLTWASYKQHFDEEPDPAAKLGVFSTGPAIRSYGFNFLTEVIATFVLVFVIFGFADYGVADIGVPGGIGGLAAVPVALLVVGIGASLGGPTGYAINPARDLGPRIAHAILPIKGKGSSDWSYAWVPVAGPLVGGLLAGLLAPVLLHLGK
>NC_015125.1|WP_013583490.1|408847_410566_+|glycerol-3-phosphate-dehydrogenase/oxidase
MSSPATSLRADVQALRDAEDIDVLIIGGGINGLATLRDLSLQGVSVALVERGDFVSGASSASSHMVHGGIRYLENGEFRLVKEAVTERNDLLKTAPHYVKPLETTIPIYKTFSGILSAPFRLLVTHGRGKPNERGALLIKVGLIMYDTFSRDGGSVPRHTFLGKKKSLQALPKLNPDLAYTATYFDASMHDPERIALDVLHDGIVAGAGRTQAVNYVSAVGADANGVRVRDEVSGEEFSVKAKVILNTAGPWTDLANAAMGLKTQFMGGTKGSHIVLDNPELLAATGGREIFFEHSDGRIVLIYPLKDRVLVGTTDIDADPAKPVVCTDDEIDYFFDLVGHVFPSIAVDRSQIVYTFSGIRPLPRHDDTAPGFVSRDYRIVEDEIAGVPAMSLVGGKWTTFRALAEHLSMKTLQKLRRPHRVSTQGLPIGGGAGFPATPEARRRWVAARTNAHSRELVEALLTRYGTRADLLLEALPAEPTPIEHAPGYYVEELEWIARNEQVVHLIDVLLRRTHLAFVGGMTERTLVEVAEAVAGPLGWDADRVQEEVERTREILLTAHRVDLAEAGVAAI
>NC_015125.1|WP_153004208.1|407774_408665_-|sugar-binding-transcriptional-regulator
MDAIAHEMRVSRSSVSRLLQHARDVGLVTISISPPDDARGQMAQRIADRFGIAAHVVPTPARTTEADRLERTALTAARILTERVESSMTVGIAWGSTLSAIARHVPAKDVHDTHIVQMNGAANVRTSGIPYAGEILSRFGTAWSSSVHQFPVPALFDDPQTKRAMWRERSVRSVLEIQDRVGLFVFGLGSPQADVPSHVYSSDYFDVRDRAVIEREGVVGDCATVFYRVDGSSDIPELNARSSGPDLDTVRRIPRRFCVVSSLSKLDALRGALAAGLVTELVVEEALARRLLSVTR
>NC_015125.1|WP_013583488.1|407045_407768_+|HPr-family-phosphocarrier-protein
MIGLVAVSHSRALADAAVELALQMGGENPPTVRVAAGGPDGDLGTDAVAIAAAIDEADSGDGVLVLMDLGSAILSAETALEFVAEPDRVRLSPAPFVEGLVAAVVTAAGGADLAAVAAECATAGDAKRRQLGEDDGAGVSASGTGEAAAEASFEAVVTNPSGLHARPAATFVKTASRYDADVRIADLDAGSEEISGRSLLALMALGIRQGSRVRVSASGPEAPAALTELRALIEDGFGER
>NC_015125.1|WP_013583487.1|406410_407049_+|dihydroxyacetone-kinase-subunit-L
MSGTVSTGDLVAWIRAFRDAVHQHKDELTRLDSEIGDADHGSNMARGLDAVVAKLDSAPANAGDLFKTVGMTLVSSVGGASGPLYGTLFLRMGPALSSDEVDATALGAALRAGVEGVVARGKAELGDKTMIDALSPALDAWDAAVTEGADAAGAARAAADAAARGRDATEPLVARKGRASYLGERSAGHLDPGAASATLLLEALRDALADAA
>NC_015125.1|WP_013583486.1|405418_406414_+|dihydroxyacetone-kinase-subunit-DhaK
MKKFVNDPADVLAEALRGIQAAYPQLRVDAENRVILRAEPTRAGKVALVSGGGSGHEPLHGGFVGRGMLDAAAAGEVFTSPTPDQVLAATQAVDSGAGVLHIVKNYTGDVLNFEMAAELAAAEGVQVESVVVADDVAVQDSTWTAGRRGTGTTVVLEKIVGASAEEGADLATVAELARRVSAAGRSMGVALTSCTVPAAGRPTFELPDDEMEVGVGIHGEPGRSRVKLASAHEIAKLMVDPIVHDFGDPVGPAIVLLSGLGGTPLIEQYLLYGEIAPLLADAGVDVQRVLIGDYITSLDMAGASLTVVKADDEMLRLWDAPVVTPGLRWGA
>NC_015125.1|WP_080575471.1|404630_405332_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MGATYVLGRSLIAPLARAVYRPRVEGRENVPRTGPVIFASNHLSFIDSIAIPVAAPRPVHFMAKSAYFEKWASRQFFTAIGAIPVERGAGQKALDALDQQRALLEDGRAVALYPEGTRSLDGRLYKGRTGVAFLALQTGAPVVPVGLIGTDKVMPVGAKIPTTKERITVRFGEPLDLSPHGPATSGRARRGATDEIMAAIHALSEQELANAYNEAPAQNPLERIKQVLPHERL
>NC_015125.1|WP_013583484.1|403508_404471_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MRFRPIASLSVAAVAVLLLAGCAGSSDDSQTPDASASPDAGQCQTPFTGDVPAGLEVSGDFQGAVTVTRPDGYAPTAIQRSTLIQGTGDEVKAGDLVKANYTVIDASTGAVALDSLKSDPSGMDMIVNAQQIFGAAVSCVPIGSRTVSTFPAGTLGEGSPAYILVADSISELPTRAEGTEVAPVEGMPTVTFADNGAPTITVPSTPAPTETRIENLRQGTGDVVNPGDTVIVQYTGVLYDGGTVFDSSWDKGAPTQFATTDVVPGFKQALEGQTVGSQVVAVIPPADGYGDQAKGSIPAGSTLVFVVDILGVQHATPTAQ
>NC_015125.1|WP_013583483.1|402416_403499_-|1-deoxy-D-xylulose-5-phosphate-reductoisomerase
MRRVLLLGSTGSIGTQALDVIRANADRFEVVGLAAGSDRAGVEAQAREFGVEHVALGAVEAEQLVRDVEADVVVNGITGSVGLGPTIAALETGRTLALANKESLIVGGDLVTALAAPGQIVPVDSEHSAIAQALRSGEAHEVRRLVLTASGGPFRGRSREQLRSVTPAEALAHPTWDMGRVVTTNSATLVNKGLEVIEAHLLFDVPYDRIDVTVHPQSIVHSMVEFIDGSTIAQASPPDMRLPISLGLDWPRRVSGVGAPLDWTTASHWTFEPLDEKAFGAVALAKKVGRAGATYPAVFNAANEQAVDAFHEGRLSFLGILEVVEAVVDRHDAPGTLTRESLAEAEDWARRTADAVIVAR
>NC_015125.1|WP_043361888.1|413292_413772_-|hypothetical-protein
MQLEPALRRLDRIAGGRQADHRVDVPDDPRVRRALRAITLLLALGFVLGVATVVIALIMTANGADVGFAVWMRCLVVLAITTTLFYFLWRARAGWYWAFRRLQLFSRIFPVVALVLAAIPGLYPFWVVTEQILFAILLIGVSDYLQSDVVRAAYPKPQR
>NC_015125.1|WP_013583494.1|413808_414279_-|OsmC-family-protein
MNGEHHYRLRSTWTGDRGSGTSGYRDYDRAVTLEVEGKPAIAASADKPFRGDPAKWNPEELLLAALSECHLLSYLHACVTTGVVVTAYEDDASGTMQEDGNSGGAFTEVVLRPRVRVADESMVEAARAAHKQAREWCFIANSVNFPVRHEPEITVG
>NC_015125.1|WP_013583495.1|414381_415365_+|asparaginase
MPATPPASVELAVVERNGFIESRHHGVAVVLAPDGSEKLTLGEATASFLPRSSMKPLQALACLSAGADLADERLAIAMASHCGTERHVETARGILQSAGLTEDDLGCPAAWPSDTAARDELVRDHGAPSPLRMNCSGKHAAMLLTCVANGWSTADYLDPQHPLQVHIREVLERLVGERMTTTAIDGCGAPVYAMSLIGLARAIQRIATSSERSPFALHRSAGTLVRAVKEHPWTIDGPGRPDTVVIERLGVFSKLGAEGVQVMTAPDGTTVALKMLDGSNRAGHAVALRLLERVGALTPAAVADTLALLPLTVSGGGHEVGGIRSTV
>NC_015125.1|WP_013583496.1|415455_416988_-|APC-family-permease
MTSAPERTSGKGLATGTLGLWGSTVIGLASTAPVYSLVATLGFVVVAVGAQAPIAFVLAFIPMLFIAFAYRELNNEVPDCGTTFTWGTKAFGPWVGWMGGWGVAVAGMVVLANLSQIAGIYLWSLIGDGSLAENVPLVTATGVAFIAAMTYVSYRGVEIGERIQNILLAVQYVVLALFVVVALWKFFDGTAPNPTPFDFAWFNPFGFTEWSGFTEAVLLALFIYWGWDTCLALNEETKDPKRIPGRAALLTTVILLGTYVTVTVAAMMYAGVGEDGAGLANASNADDVFLAMKDGLFGPFAWVLVVAVLISAVSSTQTTILPTARGTLAMAAYKALPARFQTVHPRFHTPSFSTLVMGIVASVYYVGMTIISDNILQDSILSLGLAIAFYYALTGYACVWYFRRELFTSGKNLLYRGILPLLGALMLTYAFVQSAIDMYDVDYGNSELLGIGGTFVVGIGALAFGVVLMLVWYLVPASKPFFRGESLNRDTEVLVPDEPIAYPRSVDGGI
>NC_015125.1|WP_013583497.1|417033_417807_-|serine/threonine-protein-phosphatase
MPEVTTHTRTVPLSETTLDLAWAAGTDTGKRREVNQDAVLAEYPLFVVADGMGGHLGGEIASASTVDRLQAVVSGGTVSPRHIEKALSRAVKDIVSHPETTDEGTGTTLTGLYLETTAEEPHWVTLNIGDSRVYLLRDGEIVQVTTDHSVVQELIAAGRLSPEEAENHPYGNVITRAVGPSDSVKPDYLRLEVVDGDRFVVCSDGLTKELTDFGIKHFLEANADPAAAVEAMMAAALENGGRDNITIIVLDVSRQSS
>NC_015125.1|WP_013583498.1|417925_418906_-|aldo/keto-reductase
MTSSPLPQRPVGRSGLRVSAIGLGCNNFGRAGTATETLDGTRAVLNAALDAGVTFLDTADVYGREFGLSETLMGEALQGRRDEVVLATKFGHADLAPGVPGGAKASRTSIRRSVEGSLRRLRTDWIDLYQLHTPDPSTPIDETLDALADLVREGKVRYVGHSNFSGWQIAEADHAAKGVRFVSSQNQYSLLARAAEREVLPAVDRFGLGLLPFFPLHNGLLTGKFSREGGPEHSRIMRQRPHLWRNAPWDALERYQTFCDERGITMLQATFAWFLANPLVASVIAGATSPEQVQANAAAATAWEPSVDDIAEIDGILSLPADPAAG
>NC_015125.1|WP_013583499.1|418970_419681_-|hypothetical-protein
MDILHLAYSDPYDTSGAAGLAVMGAVYAFAAVIGLIGYVIGSFLLMKVFERAGVEGKWRAWVPVYNYMVFVKLGDISPWVILGIAVAWAIPFLNFLAIPVGLVVLIMAAVRVNAKFGREWPILLLFLLSGLGVWIWLGILGFSGNRWNPAAASPSPWGSSFLADKTVWNGIPVQPAQQGAGVNGGGYGAAPQGYAAPSNPSYPPAPPASGATPPPPAPPATGTTPPPPAPPAGPQV
>NC_015125.1|WP_013583500.1|419794_420544_-|peroxide-stress-protein-YaaA
MLVLLPPSETKRRGGDGPPLRLDALAMPSLRAPREAVVDALVALSADEDEAARVLKLSAKRRHEIADNAALRSSPTMPAIDRYTGVLFDALDAGSLGATARSWVAAHVAIHSAPLGPIGALDGIPTYRLAAGTSIPGLPALRRVWAGAVSAALSTLAPSFVLDLRSEAYAALGPVPADVQSSYVRVVTGGGDSPVRALNHFNKHAKGELVRSLATTAPEIHSVGDFTAWAEASGWVVREGEPGEIALVV
>NC_015125.1|WP_013583501.1|420615_420876_-|F0F1-ATP-synthase-subunit-epsilon
MSLRVSLVSADAEVWTGEASLVVAKTVEGEIGFMQGHEPVLAILAQGEVRITRADGSKILASAQDGFLSMANDELTIVAGNAALVS
>NC_015125.1|WP_013583502.1|420877_422326_-|F0F1-ATP-synthase-subunit-beta
MSLTAEKTDAAVVGRVARVTGPVVDIEFPHDAIPEIYNALKTTITIGDESTEITLEVAQHLGDDLVRAIALKPTDGIVRGQEVRNTGGPISVPVGDVTKGKVFDVTGEVLNAAPGEQIEVTERWGIHRKAPSFDQLESKTEMFETGIKSIDLLTPYVQGGKIGLFGGAGVGKTVLIQEMIQRVAQDHGGVSVFAGVGERTREGNDLIGEMEEAGVFDKTALVFGQMDEPPGTRLRVALSALTMAEYFRDVQKQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLADEMGVLQERITSTRGHSITSLQAIYVPADDYTDPAPATTFAHLDATTELSREIASKGLYPAIDPLTSTSRILDPRYIGADHYRVATAVKQILQKNKELQEIIAILGVDELSEEDKIVVSRARRIQQFLSQNTYMAKKFTGVEGSTVPIKETIESFDAIVKGDFDHVAEQAFFNVGGISDVEAKWAQIQKENG

Crispr_ID: NC_015125_3

• CRISPR_ID: NC_015125_3
• CRISPR_location: 868066-868396
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 6 spacers

Consensus repeat of NC_015125_3

Consensus_repeat	Method
GACCCGTCGCCGAAGTTCTGGAT	CRT
CCGTCGCCGAAGTTCTGGATCTC	CRISPRCasFinder

spacers of NC_015125_3

>3.1|868089|28|NC_015125|CRT
CTCCACGCTGCCGTCGCGGTACGACCCG
>3.2|868140|27|NC_015125|CRT
CTCGACCGCTCCGGCGCGGTAGTTCCC
>3.3|868190|28|NC_015125|CRT
GCTCTCGTCGCCCCGGGCGCTGGTGCCG
>3.4|868241|28|NC_015125|CRT
CTCACGGGTCGCATCGCGGTACGTGCCC
>3.5|868292|28|NC_015125|CRT
CGTCACGTCGCCCGAGGCGTAGGAACCC
>3.6|868343|28|NC_015125|CRT
CTCGACACCGCCGATCGTCGTCGAGCCC
>3.7|868092|28|NC_015125|CRISPRCasFinder
CACGCTGCCGTCGCGGTACGACCCGGAC
>3.8|868143|27|NC_015125|CRISPRCasFinder
GACCGCTCCGGCGCGGTAGTTCCCCGC
>3.9|868193|28|NC_015125|CRISPRCasFinder
CTCGTCGCCCCGGGCGCTGGTGCCGGAC
>3.10|868244|28|NC_015125|CRISPRCasFinder
ACGGGTCGCATCGCGGTACGTGCCCGAC
>3.11|868295|28|NC_015125|CRISPRCasFinder
CACGTCGCCCGAGGCGTAGGAACCCGAG
>3.12|868346|28|NC_015125|CRISPRCasFinder
GACACCGCCGATCGTCGTCGAGCCCGAC

CRISPR arrays and Neighbor proteins around NC_015125_3

CRISPR arrays

The CRISPR arrays of NC_015125_3

>merge|NC_015125|3|868066-868396|CRT,CRISPRCasFinder
GTGCCGTCGCCGAAGTTCTGGATCTCCACGCTGCCGTCGCGGTACGACCCGGACCCGTCGCCGAAGTTCTGGATCTCGACCGCTCCGGCGCGGTAGTTCCCCGCCCGTCGCCGAAGTTCTGGATGCTCTCGTCGCCCCGGGCGCTGGTGCCGGACCCGTCGCCGAAGATCTGCACCTCACGGGTCGCATCGCGGTACGTGCCCGACCCGTCGCCGAAGTTCTGGATCGTCACGTCGCCCGAGGCGTAGGAACCCGAGCCGTCCCCGAAGTTCTGGATCTCGACACCGCCGATCGTCGTCGAGCCCGACCCGTCGCCGAAGTTGCGGATGGT

>NC_015125|3|1|868066-868393|CRT
GTGCCGTCGCCGAAGTTCTGGAT	CTCCACGCTGCCGTCGCGGTACGACCCG
GACCCGTCGCCGAAGTTCTGGAT	CTCGACCGCTCCGGCGCGGTAGTTCCC
CGCCCGTCGCCGAAGTTCTGGAT	GCTCTCGTCGCCCCGGGCGCTGGTGCCG
GACCCGTCGCCGAAGATCTGCAC	CTCACGGGTCGCATCGCGGTACGTGCCC
GACCCGTCGCCGAAGTTCTGGAT	CGTCACGTCGCCCGAGGCGTAGGAACCC
GAGCCGTCCCCGAAGTTCTGGAT	CTCGACACCGCCGATCGTCGTCGAGCCC
GACCCGTCGCCGAAGTTGCGGAT

>NC_015125|3|3|868069-868396|CRISPRCasFinder
CCGTCGCCGAAGTTCTGGATCTC	CACGCTGCCGTCGCGGTACGACCCGGAC
CCGTCGCCGAAGTTCTGGATCTC	GACCGCTCCGGCGCGGTAGTTCCCCGC
CCGTCGCCGAAGTTCTGGATGCT	CTCGTCGCCCCGGGCGCTGGTGCCGGAC
CCGTCGCCGAAGATCTGCACCTC	ACGGGTCGCATCGCGGTACGTGCCCGAC
CCGTCGCCGAAGTTCTGGATCGT	CACGTCGCCCGAGGCGTAGGAACCCGAG
CCGTCCCCGAAGTTCTGGATCTC	GACACCGCCGATCGTCGTCGAGCCCGAC
CCGTCGCCGAAGTTGCGGATGGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013583920.1|872872_873817_-|type-I-pantothenate-kinase	unknown	unknown	gnl|CDD|235466
NC_015125.1|WP_013583919.1|870972_872823_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl|CDD|234729
NC_015125.1|WP_013583921.1|873868_874798_+|hypothetical-protein	unknown	unknown	gnl|CDD|223326
NC_015125.1|WP_013583912.1|866783_867065_-|DUF4190-domain-containing-protein	unknown	unknown	gnl|CDD|379388
NC_015125.1|WP_043360989.1|863562_864195_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl|CDD|274750
NC_015125.1|WP_013583913.1|867061_867595_-|DUF3060-domain-containing-protein	unknown	unknown	gnl|CDD|237019
NC_015125.1|WP_043360992.1|866070_866799_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_015125.1|WP_013583924.1|876853_877300_-|50S-ribosomal-protein-L13	unknown	unknown	gnl|CDD|181703
NC_015125.1|WP_013583918.1|870495_870876_-|holo-ACP-synthase	unknown	unknown	gnl|CDD|234610
NC_015125.1|WP_043360987.1|860220_861408_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|380115
NC_015125.1|WP_013583909.1|864258_865182_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_015125.1|WP_158309745.1|877489_878257_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NC_015125.1|WP_013583910.1|865156_866074_-|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_015125.1|WP_013583905.1|861414_861822_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013583922.1|874988_876344_-|phosphoglucosamine-mutase	unknown	unknown	gnl|CDD|237672
NC_015125.1|WP_056228321.1|876358_876754_-|30S-ribosomal-protein-S9	unknown	unknown	gnl|CDD|178888
NC_015125.1|WP_050901837.1|868877_869327_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl|CDD|376771
NC_015125.1|WP_013583917.1|869377_870499_-|alanine-racemase	unknown	unknown	gnl|CDD|143481
NC_015125.1|WP_050901836.1|861818_862919_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl|CDD|236585
NC_015125.1|WP_013583903.1|859790_860087_-|co-chaperone-GroES	unknown	unknown	gnl|CDD|178988

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013583920.1|872872_873817_-|type-I-pantothenate-kinase	gnl|CDD|235466	PRK05439, PRK05439, pantothenate kinase; Provisional.	0
NC_015125.1|WP_013583919.1|870972_872823_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl|CDD|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_015125.1|WP_013583912.1|866783_867065_-|DUF4190-domain-containing-protein	gnl|CDD|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	5.53536e-08
NC_015125.1|WP_043360989.1|863562_864195_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl|CDD|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	8.77089e-29
NC_015125.1|WP_013583913.1|867061_867595_-|DUF3060-domain-containing-protein	gnl|CDD|237019	PRK11907, PRK11907, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	0.00047899
NC_015125.1|WP_043360992.1|866070_866799_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.4445e-71
NC_015125.1|WP_013583924.1|876853_877300_-|50S-ribosomal-protein-L13	gnl|CDD|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	3.68292e-92
NC_015125.1|WP_013583918.1|870495_870876_-|holo-ACP-synthase	gnl|CDD|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	2.56254e-44
NC_015125.1|WP_043360987.1|860220_861408_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|380115	pfam18096, Thump_like, THUMP domain-like. This is a domain of unknown function found in bacteria.	7.32368e-19
NC_015125.1|WP_013583909.1|864258_865182_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.17072e-17
NC_015125.1|WP_158309745.1|877489_878257_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.26857e-09
NC_015125.1|WP_013583910.1|865156_866074_-|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.82237e-40
NC_015125.1|WP_013583921.1|873868_874798_+|hypothetical-protein	gnl|CDD|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	3.93981e-75
NC_015125.1|WP_013583922.1|874988_876344_-|phosphoglucosamine-mutase	gnl|CDD|237672	PRK14318, glmM, phosphoglucosamine mutase; Provisional.	0
NC_015125.1|WP_056228321.1|876358_876754_-|30S-ribosomal-protein-S9	gnl|CDD|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	1.36726e-74
NC_015125.1|WP_050901837.1|868877_869327_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl|CDD|376771	pfam02367, TsaE, Threonylcarbamoyl adenosine biosynthesis protein TsaE. This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).	1.98003e-44
NC_015125.1|WP_013583917.1|869377_870499_-|alanine-racemase	gnl|CDD|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	4.31349e-136
NC_015125.1|WP_050901836.1|861818_862919_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl|CDD|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	1.38947e-178
NC_015125.1|WP_013583903.1|859790_860087_-|co-chaperone-GroES	gnl|CDD|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	7.79521e-51

Protein sequences

>NC_015125.1|WP_013583913.1|867061_867595_-|DUF3060-domain-containing-protein
MRRITTTVLTLGLAVAALTGCAVSITDDQDAAGPLASPTDASSVEVATDDPRPEVIAPPAPAASAAPEAPSNLRTRDEAIALADTTIACTPGLVIADDGKVVRVEGACDDVTVSGFATAVVLDDVSTLTVSGSGIVVYAQQVGDLVVSGDVNTILWRGNAPRLDDTGVATTSTRDTR
>NC_015125.1|WP_013583912.1|866783_867065_-|DUF4190-domain-containing-protein
MSAPVPVWGQAAPRTNGLAIAALVLGLCGFGILPVIFGHIALGQIRRTGDRGATLAIVGLVLGYLALAATVIGIGLVIVVAVGIPVFATWVSS
>NC_015125.1|WP_043360992.1|866070_866799_-|response-regulator-transcription-factor
MGVVVSDERPGILLVDDDETIRAGLGAFLERSGYRVVVAADGQEALDALPVGDIALAVCDVIMPRVDGREFVRRVRAEGRWLPIILLTQVGESYERSAALDEGADDYLNKPFDPQELLSRVRAVLRRSVPGERPLSAAPRLRAGALELDRSARRVWRDGTEVTLTPKAVMLLDYLMAHPGEVHTRDRLLTALWGFDFVTSTRAIDHRIAELRRVLGDDPGAPRYIETVQSAGYRFVHPVGAA
>NC_015125.1|WP_013583910.1|865156_866074_-|HAMP-domain-containing-histidine-kinase
MSRRSAALAIALPVTLGALVALVLFAVGERRALTVSTALPLVALFVGLALTIVAAVVVAVAARRGRTKAASDRARGEGYRSGRGEERDAHRRFLARLDHELKNPITAIRATLAGVDPADAPAHVEVIDAQARRLAALVGDLRKLSEIETRPLETEPVDLEALARDAVHAIEQQRPEARGRISVIAERVPWSVPVLPGDPDLLALALDNVLANAVKFSASGPIEVRLREDGGGAVIQVADTGRGVPTDAQSLVFDDLARAANARDVPGSGIGLSLVRTILHRHGGGVELRSREGAGTVVTLRLPTA
>NC_015125.1|WP_013583909.1|864258_865182_+|alpha/beta-hydrolase
MDPTALGLRRLVVPTAVGTIVVHAGRVSGSPVATVLLHGAAGSWRTWAPMIAASDDIRLPLSDIVAIDLPGWGESAGPVPDPGDLAVAVAAVVRALGYPRWRVVGHSLGAVVALDVAARFPSATVGVGLVSPSGEGARTVARHPLRGILTLPGLAGMVAAMHVLRGLGPLSRPLLTLLARTGMLSVLARPLFRHPSRVDRAETDALATEIRPAAFLAAARTARTHDDAVWRRVACPVRSVRGRHDVFVAARDARAWARTIIDFDEVALEDSGHFAHVEQPIPTLRALRAVWAADRAPAPVRRSATAA
>NC_015125.1|WP_043360989.1|863562_864195_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MILGIDTSLGTAVAAITRDGEVLADEQSANPLGHAEVIGDLLRRATSVAPAPTHVAIGMGPGPFTGLRVGIATARVYALGRGIPVVPVPSHDGIALGILLADALTAVETPRFAVVTDARRREFAYSVYDGIDDDGLPIRITDAALSPRDELDRRLADLGAVRSDATSVSAAMVALAAARALDAGRTLAGTEPLYLRSPDVVAAHAPKRVS
>NC_015125.1|WP_050901836.1|861818_862919_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MNAPLVLGIETSCDETGIGIVRGRQLLSNTIASSMDEHARYGGVVPEVAARAHLEALQPSIDAALAEAGVTLADLDAVAVTSGPGLAGALMVGVGAAKGLAVALDKPLYAVNHLVGHIAADILDADAGELEYPTVALLVSGGHTSLLLVRDLTSDVELLGETMDDAAGEAFDKVARLLKLPYPGGPEIDRAAASGDPTAIRFPRGLSRASDMASHRYDFSFSGLKTAVARWVEQHEAAGQPVPVADVAASFREAVVDVLVTKALDACARHGVPRLLLGGGVIANKRLRDVALERAAAAGVAVRIPPLRLCTDNGAMIAALAAELISSGRPPSTLAFGADSTLPVTEIQVAEDPDAEPPASRPGAPA
>NC_015125.1|WP_013583905.1|861414_861822_-|hypothetical-protein
MSETSPPTRRARKEVEGATALPDAGETDGEEGRLATAQLEMAAFGDHVIPYVPPTPKPPRSLAPWALGLAIVALASSFFWGWLLPLSAVAAIIAVMSVRRAHDSRRVAVWALVLSLLSGVFSAGWLIWGFSQLPA
>NC_015125.1|WP_043360987.1|860220_861408_+|class-I-SAM-dependent-methyltransferase
MDTRELTALLTPDGLRLLDEVGRIESTDDAARAVSRLRAAGHSPDLVSAVVGQARLRVRGAAKFGPFADRMLFTRAGLEQATRLSIAARHAGRFRAAGITRVADLGCGIGGDALGMAGLGLRVDAVDADEVTAAIAAYNLAPFDDAVTVRHARAEDVDLDGADAVWLDPARRTAGHSETRQVSSTEWSPSLDWVFALLAERSGGVKLGPGFDRGQIPDDVEAQWISADGSTIELVLWAGALARSDVRRAALVVRGDEAWELTAPADSPDVEPHELGAFVHEPDGAVIRARLIGEVARALEAGMLAPGIAYLTSDAALTSPFVSSFRVREQLPADPKKLAQSLRARGIGTLEIKKRGVDVDPAVLRKKLSLRGDESATLILTRVGSKRLALLADRV
>NC_015125.1|WP_013583903.1|859790_860087_-|co-chaperone-GroES
MSVSIKPLEDRIVIKQVEAEQTTASGLVIPDTAKEKPQEGEVVAVGPGRIDDNGNRVPLDVAVGDRVLYSKYGGTEVKFGAEEYLVLSARDVLAVVVR
>NC_015125.1|WP_050901837.1|868877_869327_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MEELGRALGRALEPGDVVVLTGPLGAGKTTLTRGIGEGLGIRGPVQSPTFVIARTHPSLVGGTPLVHVDAYRLGAAVELDDLDIDVARSAVIVEWGRGVAEYLADTWWEIEIDREVGGRGVDNACGEIAPHTLDLDADAPRTVTISRRP
>NC_015125.1|WP_013583917.1|869377_870499_-|alanine-racemase
MRMAPGVLREALIDVDAITENVRHFRRLTGVEVIAVVKADGYGHGAHRAAQAALRGGATRIGVSDIDEALALRRAGIHAPLFAWLHAPGASFVEAVRHDIELGISDIDQLLRAGESAQGDRPAAVHLKIETGLSRNGIAPADWRVVFAEAARLERIGRLRVVGLFSHLSNASEEDDRAALARFEEGVVLAASVGLNPPLRHIAATHAAIALPEARLTGVRIGIGIYGISPFHDRTSADLGLRPAMTLRGAVSAVRRVPAGTGVSYGYVYRTERDTTLALVPLGYADGVPRQASDRGPVVIGGRRFPVAGRVAMDQFVVDVGDHPVSVGDEVVLFGDPTLGVPAARDWGDAADTIDYEIVTRVGPRVPRREVGA
>NC_015125.1|WP_013583918.1|870495_870876_-|holo-ACP-synthase
MIVGIGVDLVDVPRFEEHLARTPRLLPRLFGPAERVLKPRSLAARYAAKEALIKALGGSDGVHWTDIEVASEPSGRPVFALHGETAVTVAARGITALHLSMSHDAGLATAYVIAEAGAQPAREDTA
>NC_015125.1|WP_013583919.1|870972_872823_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIIGYVGPRQSQDILLAGLSRLEYRGYDSAGIAVIDGEGALGMRKRAGKLAVLRDDLEASPMPNGTTGIGHTRWATHGGPTDANAHPHLADDDKLAVIHNGIIENFAELKSELVGDGFAFRSETDTEVAAVMIGREYARTKDLVQAFRSVVSRLEGAYTLLAMHEDHPGLVVGARRNSPLVIGLGEGENFLGSDVAAFVEHTRNALAIGQDEIVAITPDGVEVTDFSGAPVEVEAFEVTWDASAAEKGGWSSFMAKEVSEEPEAVANTIRGRIHEGRVEIPELEGMDDFLADIDRILVIACGTAAYAGMVGKYALETWTRVPVDVELAHEFRYRDPVLSARTLVVSISQSGETMDTLMAVKYARSRGAKTLSICNTQGATIPRESDAIVYTHAGPEVAVASTKAFVAQITALYLLALHVGRIRGAVDAMVAVEAVTELEAVPGKIARVLESEQARIEQLAHWMADTRSVLFLGRNVGYPIALEGALKLKELAYIHAEGFAAGELKHGPIALIEPGQPVFVVVPSPRGSGEMHKKVVSNIEEIRARGARVIAIAEEGDVAVLPAADEVLRIPLAAPLFEPLLAVVPLHIFAMGLAEAKGLDVDQPRNLAKSVTVE
>NC_015125.1|WP_013583920.1|872872_873817_-|type-I-pantothenate-kinase
MSETAAAPSLSPYRQIDRADWARMAGGIEQPLTETEVVQLRGIGDRLDQREVAEVYLPLSRLLSLYARATRRLGADTSTFLGEPDATTPFVIGVAGSVAVGKSTIARLLRELMSRWPDTPRVELVTTDGFLYPNAELERRGLMDRKGFPESYDRRALVEFLSEVKSGAEEVRAPFYSHVRYDIMPDAHVTVHRPDVVIVEGLNVLQPPPSPNEVAVSDLFDFSIYVDADAAHIERWYVDRFLALRDNAFTNPTSFFRVFADISDEEAVERALGFWREINLPNLEENVLPTRHRAKLVLQKGADHTVESVLLRKL
>NC_015125.1|WP_013583921.1|873868_874798_+|hypothetical-protein
MRLGVLDIGSNTVHLLVANARAGGRPTATTSHRSVLRLMRYLQPDGSISPEGVKGLVDAVAAACTTAKAEGVDELLATATSAVREATNGEEVIAQIEEVLGQPLQVLGGETEARFTYLAVRRWFGWSAGQILLFDIGGGSLEIAGGADELPDLAESVPLGAGRSTVQFLPHDPPSADEIDALRQHAMSVLAPVAERFAALPRPDHVVGSSKAIRSLAKLAGYPVPGWSGIDRMVLPRKQLKDWIPRLAQIPADAREALPGITADRTFQIVAAAVVVERAMKAMDVEELEVSPWALREGVLLRYIESLEY
>NC_015125.1|WP_013583922.1|874988_876344_-|phosphoglucosamine-mutase
MPLFGTDGVRGLANGLLTAELALHLAQATAVVLGQGRSAEARKAEGRRLTAVVARDPRVSGEFLSAAVAAGLASSGVDVLDAGVIPTPATAFLIADRDADFGVMVSASHNPAPDNGIKIFARGGTKLPDIVEQRIERALEGERLQPTGAGVGRIRRFADAEDRYVLHLLGSLPHRLDGIHVVLDCAHGAAAGVSPETFKDAGATVTVIGADPDGLNINDGVGSTHLDVLAETVVRLGADVGIAHDGDADRCLAVDAQGNVVDGDQIMAILAVAMKERGTLVDDTLVATVMSNLGLHRAMEAHGIRVLQTGVGDRYVLEAMNEGGYSLGGEQSGHVIMSDFATTGDGLLTGLHVVAEMARQGKTLAELASLMTVYPQVLVNVRGVDRDGVGDEGVQAAVAASTAELGDSGRVLLRASGTEPLVRVMVEAASEDVARAHADRLAEVVRERLAL
>NC_015125.1|WP_056228321.1|876358_876754_-|30S-ribosomal-protein-S9
MLSVPGAAVGRRKQAIARVRLVPGSGTITVNGRTIEDYFPNKLHQQLINDPFTVLELAGSYDVIARISGGGPSGQAGALRLGIARALNEIDAENNRPTLKKAGFLSRDARVKERKKAGLKKARKAPQYSKR
>NC_015125.1|WP_013583924.1|876853_877300_-|50S-ribosomal-protein-L13
MTRTFTPKAAEVTREWVVIDATDVVLGRLASHAAVLLRGKHKATFANHIDSGDFVIVINAEKVALTGQKLQKKKAYRHSGYPGGLKSVTYDELLEKNPVRAVEKAIRGMLPKNSLGAAQLKKLKVYRGAEHPHGAQQPTAYTFDQVAQ
>NC_015125.1|WP_158309745.1|877489_878257_-|CPBP-family-intramembrane-metalloprotease
MRLPDVAAADIPPSRRRRHRRNRPWREGGASTARWGADLLGWAMVALGAGALGARAVSILLPVGDAPAAAQAVIWMSSAVPVVVAWSRSRPLGLLRFRGLDVVYGVVFGVILRFCQGALAQSEGGSLPWPSTPSIPGTLPDGFSGDVVAGVAVAPVLEELFFRGVVLVCAYTVVRRWSGRVAGGVAAAAISSAFFVGAHLLVAPMSASDVWALVLVGVVAAALVLGTGRIWAAVATHVVFNATGLALVAVGTLWG

Crispr_ID: NC_015125_4

• CRISPR_ID: NC_015125_4
• CRISPR_location: 1249048-1249228
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_015125_4

Consensus_repeat	Method
CAACACCGTCTCGGGCGAC	CRT

spacers of NC_015125_4

>4.1|1249067|35|NC_015125|CRT
ATCATCGTCGACGGCCTCGTGGGCGACGTCAACGC
>4.2|1249121|35|NC_015125|CRT
GTGCAGGTGCGGGAGCTCGAAGGCTCCCTGAGCGC
>4.3|1249175|35|NC_015125|CRT
GTCACGGTGACCGGTGCCGTCACCAAGGCCTCCAT

CRISPR arrays and Neighbor proteins around NC_015125_4

CRISPR arrays

The CRISPR arrays of NC_015125_4

>merge|NC_015125|4|1249048-1249228|CRT
CAACACCGTCTCGGGCGACATCATCGTCGACGGCCTCGTGGGCGACGTCAACGCCAACGCCGTCTCGGGCGACGTGCAGGTGCGGGAGCTCGAAGGCTCCCTGAGCGCCAACAGCGTCTCGGGCGACGTCACGGTGACCGGTGCCGTCACCAAGGCCTCCATCGACACGGTCTCGGGCGCG

>NC_015125|4|2|1249048-1249228|CRT
CAACACCGTCTCGGGCGAC	ATCATCGTCGACGGCCTCGTGGGCGACGTCAACGC
CAACGCCGTCTCGGGCGAC	GTGCAGGTGCGGGAGCTCGAAGGCTCCCTGAGCGC
CAACAGCGTCTCGGGCGAC	GTCACGGTGACCGGTGCCGTCACCAAGGCCTCCAT
CGACACGGTCTCGGGCGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013584268.1|1251042_1252260_-|MFS-transporter	unknown	unknown	gnl|CDD|340897
NC_015125.1|WP_013584257.1|1243748_1244678_-|carbohydrate-kinase-family-protein	unknown	unknown	gnl|CDD|223598
NC_015125.1|WP_013584275.1|1257330_1257687_-|hypothetical-protein	unknown	unknown	gnl|CDD|380033
NC_015125.1|WP_013584254.1|1240255_1241533_+|MFS-transporter	unknown	unknown	gnl|CDD|340871
NC_015125.1|WP_013584263.1|1248192_1248357_+|hypothetical-protein	unknown	unknown	gnl|CDD|378333
NC_015125.1|WP_013584270.1|1253738_1254881_-|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl|CDD|235439
NC_015125.1|WP_013584265.1|1249533_1250139_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NC_015125.1|WP_050901759.1|1255075_1255930_-|DUF559-domain-containing-protein	unknown	unknown	gnl|CDD|225408
NC_015125.1|WP_043362213.1|1243026_1243647_-|class-II-aldolase/adducin-family-protein	unknown	unknown	gnl|CDD|376358
NC_015125.1|WP_013584274.1|1256785_1257121_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013584273.1|1256171_1256783_+|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013584255.1|1241576_1243025_-|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143417
NC_015125.1|WP_043362216.1|1250143_1250659_-|universal-stress-protein	unknown	unknown	gnl|CDD|366180
NC_015125.1|WP_013584262.1|1247686_1247956_-|Rho-termination-factor-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|236490
NC_015125.1|WP_013584269.1|1252256_1253732_-|amidophosphoribosyltransferase	unknown	unknown	gnl|CDD|236427
NC_015125.1|WP_013584261.1|1246717_1247683_-|DNA-topoisomerase-IB	unknown	unknown	gnl|CDD|226099
NC_015125.1|WP_013584260.1|1245756_1246743_+|cation-transporter	unknown	unknown	gnl|CDD|223131
NC_015125.1|WP_043361087.1|1245265_1245760_+|hypothetical-protein	unknown	unknown	gnl|CDD|270230
NC_015125.1|WP_013584267.1|1250823_1251006_+|DUF3073-domain-containing-protein	unknown	unknown	gnl|CDD|378620
NC_015125.1|WP_013584258.1|1244777_1245149_-|CrcB-family-protein	unknown	unknown	gnl|CDD|223317

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013584268.1|1251042_1252260_-|MFS-transporter	gnl|CDD|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.84691e-79
NC_015125.1|WP_013584257.1|1243748_1244678_-|carbohydrate-kinase-family-protein	gnl|CDD|223598	COG0524, RbsK, Sugar kinases, ribokinase family [Carbohydrate transport and metabolism].	9.56991e-46
NC_015125.1|WP_013584275.1|1257330_1257687_-|hypothetical-protein	gnl|CDD|380033	pfam17844, SCP_3, Bacterial SCP ortholog. This domain is found in MSMEG_5817 gene product from M. smegmatis. It has been shown to be vital for mycobacterial survival within host macrophages. Crystal structure revealed a Rossmann-like fold alpha/beta two-layer sandwich forming a highly hydrophobic interface cavity and with high structural homology to the SCP family. Hence, it has been suggested that this domain may be involved in the interaction of apolar ligands through its hydrophobic cavity. Alanine-scanning mutagenesis of the hydrophobic cavity of MSMEG_5817 protein demonstrated that the conserved Val82 residue plays an important role in ligand binding.	1.80691e-50
NC_015125.1|WP_013584254.1|1240255_1241533_+|MFS-transporter	gnl|CDD|340871	cd17313, MFS_SLC45_SUC, Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters. This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.77719e-21
NC_015125.1|WP_013584263.1|1248192_1248357_+|hypothetical-protein	gnl|CDD|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	0.00950597
NC_015125.1|WP_013584270.1|1253738_1254881_-|phosphoribosylformylglycinamidine-cyclo-ligase	gnl|CDD|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	6.99359e-157
NC_015125.1|WP_013584265.1|1249533_1250139_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	6.34898e-23
NC_015125.1|WP_050901759.1|1255075_1255930_-|DUF559-domain-containing-protein	gnl|CDD|225408	COG2852, COG2852, Very-short-patch-repair endonuclease [Replication, recombination, and repair].	1.20651e-06
NC_015125.1|WP_043362213.1|1243026_1243647_-|class-II-aldolase/adducin-family-protein	gnl|CDD|376358	pfam00596, Aldolase_II, Class II Aldolase and Adducin N-terminal domain. This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.	6.39442e-48
NC_015125.1|WP_013584255.1|1241576_1243025_-|aldehyde-dehydrogenase-family-protein	gnl|CDD|143417	cd07099, ALDH_DDALDH, Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like. The 4,4'-diapolycopene-dialdehyde dehydrogenase (DDALDH) involved in C30 carotenoid synthesis in Methylomonas sp. strain 16a and other similar sequences are present in this CD. DDALDH converts 4,4'-diapolycopene-dialdehyde into 4,4'-diapolycopene-diacid.	0
NC_015125.1|WP_043362216.1|1250143_1250659_-|universal-stress-protein	gnl|CDD|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.78361e-14
NC_015125.1|WP_013584262.1|1247686_1247956_-|Rho-termination-factor-N-terminal-domain-containing-protein	gnl|CDD|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	8.72536e-05
NC_015125.1|WP_013584269.1|1252256_1253732_-|amidophosphoribosyltransferase	gnl|CDD|236427	PRK09246, PRK09246, amidophosphoribosyltransferase; Provisional.	0
NC_015125.1|WP_013584261.1|1246717_1247683_-|DNA-topoisomerase-IB	gnl|CDD|226099	COG3569, COG3569, Topoisomerase IB [DNA replication, recombination, and repair].	3.15119e-60
NC_015125.1|WP_013584260.1|1245756_1246743_+|cation-transporter	gnl|CDD|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	1.52466e-42
NC_015125.1|WP_043361087.1|1245265_1245760_+|hypothetical-protein	gnl|CDD|270230	cd01009, PBP2_YfhD_N, The solute binding domain of YfhD proteins, a member of the type 2 periplasmic binding fold protein superfamily. This subfamily includes the solute binding domain YfhD_N. These domains are found in the YfhD proteins that are predicted to function as lytic transglycosylases that cleave the glycosidic bond between N-acetylmuramic acid and N-acetylglucosamin in peptidoglycan, while the YfhD_N domain might act as an auxiliary or regulatory subunit. In addition to periplasmic solute binding domain, they have an SLT domain, typically found in soluble lytic transglycosylases, and a C-terminal low complexity domain. The YfhD proteins might have been recruited to create localized cell wall openings required for transport of large substrates such as DNA. They belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.61748e-08
NC_015125.1|WP_013584267.1|1250823_1251006_+|DUF3073-domain-containing-protein	gnl|CDD|378620	pfam11273, DUF3073, Protein of unknown function (DUF3073). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.61281e-15
NC_015125.1|WP_013584258.1|1244777_1245149_-|CrcB-family-protein	gnl|CDD|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	2.50934e-15

Protein sequences

>NC_015125.1|WP_013584263.1|1248192_1248357_+|hypothetical-protein
MNIFLIIIIVAAIVIAIVSGMSQAASFLLWVAIIVGLIALIVLLFRLISGRKPV
>NC_015125.1|WP_013584262.1|1247686_1247956_-|Rho-termination-factor-N-terminal-domain-containing-protein
MPQGRGSNSLKDPELYEELRKQGDSKEKAARISNAAAAQGRGAVGEKGGHAENYEDRTVDELKKRAKELGITGYSGKKKAELIDMLRHH
>NC_015125.1|WP_013584261.1|1246717_1247683_-|DNA-topoisomerase-IB
MARLIRVRPYEDPGYRRVRSGSGYRFVDHTGAPVPEREAERARGLVIPPAWREVWIAREPNAHIQAVGTDEAGRRQYTYHADWSKRQDKGKFARALQLAEALPRARARVTQSLRRSEIDRERVLAVSFRLLDLVAPRVGNARYFVTNGSRGLTTLQRRDATIEGDLIRLSFPAKSGKRADLRVHDAELASLIEELALGRSRAALLSYKRGRRRVPLTPGDVNAYVRSLTGGPFSAKDFRTLRGTIMAAESLAKVGAVGGKNERKKAEVAAVRATAEALGNTPAVAKSSYIDPRVFSLYRKGRTMELGGSKDAAIRRLILGE
>NC_015125.1|WP_013584260.1|1245756_1246743_+|cation-transporter
MTARFGRTELPARQAEVLRRAVRLEGITLGFLAVTVTLVFLVLGNSQAMKAAWIEDLLSFIPPIAFLVAVRLARRRPTVRHPYGFHRSVAIGHLVAAVALTGMGAFLIVDSGIGLLTAEHPTIGTVNLFGVTIWLGWLMIAVMALTGIPPVVVGRMKLGLARELHDKVLYADADMNKADWMTSVGTIVGVLGIGVGLWWMDAAAALFIAGSIVHDGISNLRAAVVDLMDARATTFDDARPHPLVGRVDQYLAGLPWVREAGSRVRDEGHVFHIEAFVVPRHRKVALADIEDAREGCVILDWKIQDVVVVPVPELPDVVDAITPRGSNA
>NC_015125.1|WP_043361087.1|1245265_1245760_+|hypothetical-protein
MSRSRPVIVVVAALCALLLAGCGIRIPSDPQGTLDRVEGGVLRAGISPNGDFVQVDGAQPSGSEIDALTAFAGSVDAEVEWTVGSEEALVRGLENGDLDVVAGGLTDDTPWTDKAGMTRPYGEVTLDDGSTARIVMLVPLGENAFVSRLETFLTAEATIEGVGR
>NC_015125.1|WP_013584258.1|1244777_1245149_-|CrcB-family-protein
MSVWRDVVLVAVGGAIGTAVRAGLTLGLGDDLGPALVPLVNVVGAFAIGIVFGFRARMPESSRAQRAQLFLGTGVLGGFTTYSSLALESADLTQLWWGVATVIVGTAAAWAGVALGRGSRRPR
>NC_015125.1|WP_013584257.1|1243748_1244678_-|carbohydrate-kinase-family-protein
MTAAPRIVTLGAHVLDTIVQPVDEIPDGQGSLLVDEIVMSAAGPAGGTALVLARLGAHVVTSGSVGDDVTGRVLVGLLADEGIDVENLRVGELPTSASVLPIRSDGSRPALHVVGANALAADVVPWDALAAADHVHVGAPELLGPENVIEILDYAREHGATTSLDFLIGGEQAFYALIEPLLAHTDYVLPNAEQALGWTEAADLHAAAHAMASAGARVVAITDGGRDIVLVEDGDLREIPILPAEPVDTSGGGDAFSAGFVFAKLLGRSSAEAARFGSATAAQVVAGVGTSYGTYDAASIDALLATVPR
>NC_015125.1|WP_043362213.1|1243026_1243647_-|class-II-aldolase/adducin-family-protein
MAAVCRALAADGLVKGTAGNVSVRVDGGIAITATGVVFAEAVADDVVVVGDDRRLVRGSLAPSSELDLHLAAYADDAVGAVVHTHAPAAVAVSLISDRLPCVHYQQLTLGGEIEVVPFSVFGSRELAEATGDALSSANAVILAHHGAVTTGRDLADAVAHTALLEWACDIYLRARAAGEPAELSPAQQADVVAAAVATGYGQKHEA
>NC_015125.1|WP_013584255.1|1241576_1243025_-|aldehyde-dehydrogenase-family-protein
MTFDSLSPLDGHVVGTFPVCDDDAVRAAVVRARTGARAWRAQGFRGRRRILDAWRRDIALHLDELIAVVRAETGKPSGDARLEILLALDHLAWAAAHAERTLRRRRVRAGLLMINQSASLGYLPYGVVGVIGPWNYPVFTPMGSLAYALAAGNAVVFKPSEYTPAVGDWLRRAFVRAGGAPEVFELVTGLGDTGAALSRAGVDKIAFTGSTATGKRVMAACAETLTPVVIEAGGKDALLIDADADIEAAAEAAVWGAYSNAGQTCIGIERVYAHTLVYDRVVAAISERVRELRAGTDDAARLGPLTMPRQADVVREHVADALAAGGVLREGAVVESGQTLAPVLLLDVPESSAAVREETFGPTLVVNRVASMDEAVAKANAVRYGLSGAVFSRRRGRALAERLRGGMIAINSVISFAAVPSLPFGGVGDSGFGRIHGADGLREFAYAKAITRQRFRLLTLTTMRRTPRVDALVQRIIRLLYG
>NC_015125.1|WP_013584254.1|1240255_1241533_+|MFS-transporter
MTSDGRTVPVAVYAEPTRPVRAGWIAAFAGAWLGLWMAQLVPVQVLLPLQIAAQHSSDEWLTSLVSYGLVSAVAGAFVVVAYPIVGALSDRTRSRFGRRRPWILGGSLTAGVGLALLGIQTGTVGTIGMWTVVMLGFCMASAALTAVMADQVPENQRGLVSGWISAPNALGILLGIVLVTAVFTTIPSGYLALAVSVVVLAVPFVLRLRDAPLSPVDAARLGPLTVRSVLASIWVDPRRHPDFAWTVASRVLINLGNAIATTMLLYFFTFALGVADPTGFLVFTTVIYMVVTIVASIALGKLSDVLGRRRVFVLASGVAQALAALLLAVAPAESTSIVGAVLLGLGQGCFFAVDQALATQVLPSAETRGKDVGIMNIAMAGPQAFGPLLGAGAVVLFGGFPGLFIASGVTGLLGAAVVMRVRSVR
>NC_015125.1|WP_013584265.1|1249533_1250139_+|helix-turn-helix-transcriptional-regulator
MSPVFSHGGLRLYILSLLDEAPRHGYDLMQALSDRTGGTYSPSAGTIYPRLAKLEDEGLVTKTVDGRKTVYEITDAGRAEVAARTGDLEGIQAELADSVRLIADEVRGSVRDAMRSLRADLAAASREEREHADTAPVDDARSRTREQLHRADAAITEFRGRVRSELRSHVARGGELAASGVDEIETALRQASDAVARAMRG
>NC_015125.1|WP_043362216.1|1250143_1250659_-|universal-stress-protein
MSDHEAGAAASGAVIAGVVPGQPPRVVREAARYAALAGVELIVAHVDTTRFVAFEDPDGYVNSATLDVAGEVARAALAEVEKDATAALAGEDVRWSARQVIGDPALALIQLADEVGASLLVVGTRKRGLGESLREFLTGSVAARLSHRQHRPVLVVPLGEPVGAHEELPWE
>NC_015125.1|WP_013584267.1|1250823_1251006_+|DUF3073-domain-containing-protein
MGRGRQKAKHTKIARELKYDTYSVNYAALERELGAPEPGEDAYVDKWADEYSDEYEDEKA
>NC_015125.1|WP_013584268.1|1251042_1252260_-|MFS-transporter
MSPRRAGTVALAAAAIVLLALTLRIAVASLSPLLIVIERDFPLPAAIVGLIGMAPPVAFAISGFVTPAIERRVGLERLVLVAAVVAAVMLGMRALAVDAITLLAATAGIFAAVGVANVLLPAVVKKYFPARIGLMTTIYTTTMAVATFMPPLVAVPLAESVGWRGSFTLWAAVALAAVVPWVAMSLRARAARADVIEQPKTSVLSRVVRVPQTWALAATFAVNSSVAYGLFAWLPPLVMGVAGVDATEAGGLLALFSFMGLPVSLVVPLLVVRARTVAPFYVVAVVGGLAGVAGLLFAPAAATTLWVVLIGIPPLMFPMALVLFGLRTRSHDTAVALSGFVQSVGYGVAALMPLAIGVTHEVTGGWTAGLIVLGVVIACVIPAGIVVSRGETIEEAWERRHGTAW
>NC_015125.1|WP_013584269.1|1252256_1253732_-|amidophosphoribosyltransferase
MCGIVGMAGQGPVNQEIYDALLLLQHRGQDSTGMATAESSGVFHIHKARGQVREAFRTRDMRALLGDIGLGHVRYATKGTASNEEEAQPFYVNAPYGIVLVHNGNLTNTRELTTELFHKDRRHLNTSSDTELLVNILGSELQSEITGPDLDPAQVFRAVGRVHERVEGSYASIALIAGYGLLAFRDPFGIRPLILGKRPAPEVPGRESRDEYIVASESLVLENAGFEVVRDVEPGEAVFISLDGTLHAQQCAKSTMLAPCSFEYVYLARPDSVMNGVSVYETRLRMGERLADTVAKYTPAGSIDVVMPIPDSARPAAMQVARKLGIEYREGFYKNRYVGRTFIMPGQAVRKKSVRQKLNAMSTEFQGKNVLLVDDSIVRGTTSREIIQMARDAGAKSVTFASAAPPVRYPHVYGINMPSRHELVAHGRTIPEIAEELGCDYLVYQEVDDLKAAIMEGTDLVDLDMSCFDGRYVTGTVSEEYLAWVEGSQES
>NC_015125.1|WP_013584270.1|1253738_1254881_-|phosphoribosylformylglycinamidine-cyclo-ligase
MASAPHENPYSAAGVDTAAGDLAVELMKSAVRRTHGPEVLGGVGGFAGLFDASALRDYAKPLLATSTDGVGTKVAIAQAIDKHDTIGEDLVGMVVDDIVVVGARPLFMTDYIACGKVVPQRIADIVAGIARGCAMTGTALVGGETAEHPGLLGIDDYDVAGAATGVVEADRVLGADRVRGGDVVLALASSGLHSNGYSLVRHIITGAGIAYGSASADLGGTWGEALLEPTRLYTSPLLRLLDDAAVGSGIHSLSHVTGGGIAANLARVLPQNTWVDVDRSTWSPSPVFRVLADIGGLELTATEGTWNLGIGFLAVVSPEIADAATAALTADGIATWQVGVVRDDQRPEGDYEQGAKGVDGGAVRLVGSYADAGAPANGAK
>NC_015125.1|WP_050901759.1|1255075_1255930_-|DUF559-domain-containing-protein
MSAGLSRRIEALRARVRALEGVVATSRLQREGVSVDTIAAAVRSGAVLRIRRRWIALPDADAFLLAAARGGVVLACSTAATRHGLWVLDQHDVHVAAPAHAGRISVAEGTRAHRSQPLLPRHPEDLVDGVINVLGLVSGCLPPEQALAIWDSALNKRLVTLDEMRRYPLTGRARQIAEQATPLADSGLETFLLVRLRWLRERLCAQAWILGRRVDLLIGDRLVVQVDGGHHVGAQREADIRHDALLALNGYHVIRVGYHQVVNDWPSGQLMITQAVAQGLHRIR
>NC_015125.1|WP_013584273.1|1256171_1256783_+|hypothetical-protein
MTAGQPEWVIREDAASPVLVALYLRQVLGIRSPEELPFLRRVPPTPESGRADAAQSELERQWRAYWAMTVEPQAHPSPVPLELVDGFDGLVTLPVEGADALREAAAPFADDATDYAQHAHGRYARETAARPGVSYRAYASAIAAHERIVGRRAHSFELNVQILPLAQRGVWWIGSLTVAVTDGLRGDVAAFDSAIHPIIAELA
>NC_015125.1|WP_013584274.1|1256785_1257121_-|hypothetical-protein
MAEQPAPDRPSISRDDIETVSVRRAPKYGVFLAAGAFVGILAALVLTFAIDGADVSPFTQVVYSQLQVFGFTALICVVIGVTIAAIIALIFERTLGGRTRQVVVDHEQHGA
>NC_015125.1|WP_013584275.1|1257330_1257687_-|hypothetical-protein
MPPRRIETGDGRAALEAVAAGDAPRPALATAVRYLLQLLAEKAPGNSVEMRVPPFGAVQVIEGPRHTRGTPPNVVETDAATWIAVATGREHWTDAVAAGRIVASGVRADLSALLPLRP

Crispr_ID: NC_015125_5

• CRISPR_ID: NC_015125_5
• CRISPR_location: 1400796-1400923
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_5

Consensus_repeat	Method
CCTCGTCCCACTTTTGGCCGGTGCATGTCCCACATA	CRISPRCasFinder

spacers of NC_015125_5

>5.1|1400832|56|NC_015125|CRISPRCasFinder
TGGCTACCCGGCGGTAGCTCGACCGACCAAAGTGGGACATGGGGGCGGGGGCGGAA

CRISPR arrays and Neighbor proteins around NC_015125_5

CRISPR arrays

The CRISPR arrays of NC_015125_5

>merge|NC_015125|5|1400796-1400923|CRISPRCasFinder
CCTCGTCCCACTTTTGGCCGGTGCATGTCCCACATATGGCTACCCGGCGGTAGCTCGACCGACCAAAGTGGGACATGGGGGCGGGGGCGGAACCTCGTCCCACTTATGGCCGGTGCATGTCCCACATA

>NC_015125|5|4|1400796-1400923|CRISPRCasFinder
CCTCGTCCCACTTTTGGCCGGTGCATGTCCCACATA	TGGCTACCCGGCGGTAGCTCGACCGACCAAAGTGGGACATGGGGGCGGGGGCGGAA
CCTCGTCCCACTTATGGCCGGTGCATGTCCCACATA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013584407.1|1395191_1396214_-|methylenetetrahydrofolate-reductase-C-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|238299
NC_015125.1|WP_013584412.1|1401883_1402498_-|GrpB-family-protein	unknown	unknown	gnl|CDD|377252
NC_015125.1|WP_013584421.1|1412996_1413632_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|380339
NC_015125.1|WP_013584410.1|1397902_1400746_+|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224446
NC_015125.1|WP_013584414.1|1402945_1404229_-|allantoate-amidohydrolase	unknown	unknown	gnl|CDD|236456
NC_015125.1|WP_013584402.1|1389237_1390428_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274819
NC_015125.1|WP_013584408.1|1396319_1396934_+|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl|CDD|235555
NC_015125.1|WP_013584406.1|1394519_1394948_-|SRPBCC-family-protein	unknown	unknown	gnl|CDD|176871
NC_015125.1|WP_013584413.1|1402557_1402926_+|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_043361117.1|1408938_1410273_-|allantoinase-AllB	unknown	unknown	gnl|CDD|238640
NC_015125.1|WP_148272941.1|1410324_1411038_-|aspartate/glutamate-racemase-family-protein	unknown	unknown	gnl|CDD|226611
NC_015125.1|WP_167539382.1|1407574_1408867_-|acetamidase/formamidase-family-protein	unknown	unknown	gnl|CDD|225279
NC_015125.1|WP_013584401.1|1387333_1388749_-|FAD-binding-protein	unknown	unknown	gnl|CDD|273050
NC_015125.1|WP_148272939.1|1405707_1407369_-|DUF3225-domain-containing-protein	unknown	unknown	gnl|CDD|181375
NC_015125.1|WP_013584409.1|1396935_1397766_+|FAD-binding-domain-containing-protein	unknown	unknown	gnl|CDD|224238
NC_015125.1|WP_013584404.1|1391803_1393708_+|FAD/NAD(P)-binding-protein	unknown	unknown	gnl|CDD|379196
NC_015125.1|WP_043362285.1|1400979_1401840_-|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl|CDD|223461
NC_015125.1|WP_013584415.1|1404419_1405652_-|alanine--glyoxylate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|223153
NC_015125.1|WP_013584405.1|1394056_1394512_-|winged-helix-DNA-binding-protein	unknown	unknown	gnl|CDD|197670
NC_015125.1|WP_013584403.1|1390424_1391807_+|NtaA/DmoA-family-FMN-dependent-monooxygenase	unknown	unknown	gnl|CDD|274819

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013584407.1|1395191_1396214_-|methylenetetrahydrofolate-reductase-C-terminal-domain-containing-protein	gnl|CDD|238299	cd00537, MTHFR, Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase to convert homocysteine to methionine. The enzymatic mechanism is a ping-pong bi-bi mechanism, in which NAD(P)+ release precedes the binding of methylenetetrahydrofolate and the acceptor is free FAD. The family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from prokaryotes and methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The bacterial enzyme is a homotetramer and NADH is the preferred reductant while the eukaryotic enzyme is a homodimer and NADPH is the preferred reductant. In humans, there are several clinically significant mutations in MTHFR that result in hyperhomocysteinemia, which is a risk factor for the development of cardiovascular disease.	3.50555e-17
NC_015125.1|WP_013584412.1|1401883_1402498_-|GrpB-family-protein	gnl|CDD|377252	pfam04229, GrpB, GrpB protein. This family has been suggested to belong to the nucleotidyltransferase superfamily. It occurs at the C-terminus of dephospho-CoA kinase (CoaE) in a number of cases, where it plays a role in the proper folding of the enzyme.	1.087e-45
NC_015125.1|WP_013584421.1|1412996_1413632_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.82252e-20
NC_015125.1|WP_013584410.1|1397902_1400746_+|molybdopterin-dependent-oxidoreductase	gnl|CDD|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	1.17564e-155
NC_015125.1|WP_013584414.1|1402945_1404229_-|allantoate-amidohydrolase	gnl|CDD|236456	PRK09290, PRK09290, allantoate amidohydrolase; Reviewed.	3.00699e-155
NC_015125.1|WP_013584402.1|1389237_1390428_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	1.56091e-56
NC_015125.1|WP_013584408.1|1396319_1396934_+|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl|CDD|235555	PRK05679, PRK05679, pyridoxal 5'-phosphate synthase.	9.35261e-36
NC_015125.1|WP_013584406.1|1394519_1394948_-|SRPBCC-family-protein	gnl|CDD|176871	cd08862, SRPBCC_Smu440-like, Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Streptococcus mutans Smu.440 and related proteins. This domain belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Streptococcus mutans is a dental pathogen, and the leading cause of dental caries. In this pathogen, the gene encoding Smu.440 is in the same operon as the gene encoding SMU.441, a member of the MarR protein family of transcriptional regulators involved in multiple antibiotic resistance. It has been suggested that SMU.440 is involved in polyketide-like antibiotic resistance.	1.50962e-16
NC_015125.1|WP_043361117.1|1408938_1410273_-|allantoinase-AllB	gnl|CDD|238640	cd01315, L-HYD_ALN, L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in biotechnology). But L-HYDs differ by having an L-enantio specificity and by lacking activity on possible natural substrates such as dihydropyrimidines. Allantoinase catalyzes the hydrolytic cleavage of the five-member ring of allantoin (5-ureidohydantoin) to form allantoic acid.	1.32544e-179
NC_015125.1|WP_148272941.1|1410324_1411038_-|aspartate/glutamate-racemase-family-protein	gnl|CDD|226611	COG4126, COG4126, Hydantoin racemase [Amino acid transport and metabolism].	2.17349e-58
NC_015125.1|WP_167539382.1|1407574_1408867_-|acetamidase/formamidase-family-protein	gnl|CDD|225279	COG2421, COG2421, Predicted acetamidase/formamidase [Energy production and conversion].	3.54039e-52
NC_015125.1|WP_013584401.1|1387333_1388749_-|FAD-binding-protein	gnl|CDD|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	1.57123e-106
NC_015125.1|WP_148272939.1|1405707_1407369_-|DUF3225-domain-containing-protein	gnl|CDD|181375	PRK08310, PRK08310, amidase; Provisional.	2.32109e-118
NC_015125.1|WP_013584409.1|1396935_1397766_+|FAD-binding-domain-containing-protein	gnl|CDD|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	6.49317e-15
NC_015125.1|WP_013584404.1|1391803_1393708_+|FAD/NAD(P)-binding-protein	gnl|CDD|379196	pfam13454, NAD_binding_9, FAD-NAD(P)-binding.	6.89859e-39
NC_015125.1|WP_043362285.1|1400979_1401840_-|PhzF-family-phenazine-biosynthesis-protein	gnl|CDD|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	1.53671e-60
NC_015125.1|WP_013584415.1|1404419_1405652_-|alanine--glyoxylate-aminotransferase-family-protein	gnl|CDD|223153	COG0075, COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism].	1.84337e-136
NC_015125.1|WP_013584405.1|1394056_1394512_-|winged-helix-DNA-binding-protein	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	7.88243e-16
NC_015125.1|WP_013584403.1|1390424_1391807_+|NtaA/DmoA-family-FMN-dependent-monooxygenase	gnl|CDD|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	4.24015e-144

Protein sequences

>NC_015125.1|WP_013584410.1|1397902_1400746_+|molybdopterin-dependent-oxidoreductase
MKFEVNGVPVDAEPRPGQSARTLLRETGHVEVKKGCDAGDCGACSVLLDGEPTHSCIIPAMRLEGRTLTTAAGLAPGDDLHPVQEALASGFGFQCGFCTPGMSVTASTLTADDLPDLDRRMKGNLCRCTGYRPIREAIRSSVLGPVRETGALSDATAPAAAACGSGCAGHNADGAASGPAAGDGRVGASTVPEAARRIVQGREPFTFDEPVPGGPPLVLRVVTSPHAHARVRSIDTEAALAIPGVVAVFTHDDVPEIRYSTGRHEHRTDDPDDTRMLDDVVRHVGQRVVAVVGETAEAADAGCRAVRIEYDVLPAVFDPEEARRPGAPLLHPDRTPDERVMEAGRNVVAGFHTGHGGDIHAALAASHTTVTGEWTSSRVTHAALETHGAVAWLDDDGRLVVRSSTQVPFLVRNELAHILEVSPDRIRVYANRVGGGFGGKQELFTEDLTALAVLKLGRPVAYEFSRTDQFVRASLRHPMRVRVTLGSDADGVLTAMKVDVLSDTGAYGNHAIGVLFHSCAESTTLYRVPVKWIDAEAVYTNNPPSGAFRGYGLGQVVFGVESALDALAVELDMDPFDLRRINAVREGDPLHPDDDEKYEEDLIWGSYGLDQCLDLAQDALARGNGVDAPEGWLVGEGMAASMIATMAPRGHIAHTTATLRPDGTYLLRVGTAEFGNGTSTVHRQIAATVLDAAPERLELWAADTDAVRHDTGAFASAGTVVAGKALFGACTVLRRRMVDIATELADGDAVPGGVDVELVASGVRVDGTVVSWARIIAAAPADFRDGDGLTADGAEFGDLRSLAFNVHAARVAVDPETGTVKVLQSIQSADAGVVINPAQCRGQIEGGVAQALGGALYEEVLVEDGVVQNPVFRTYRVPQFADVPDTEVYFAETDDSLGPFGAKSMSESPYNPVGAAIGNAVSRAVGRRGYTLPFSRDRVWRLAGGGG
>NC_015125.1|WP_013584409.1|1396935_1397766_+|FAD-binding-domain-containing-protein
MDITTVTSFRSARTRADLQLAPGEVVLAGGTWLMSEPQPTTTGFVDLTTLAWPDIEITDAGLRIGATCTIARLLAWAETEAPPEWTSLALARPSADALLASFKIWNTATVGGNVCQAFAAGAMIAMLSTLDATALIWTPDGGEREIAVADLVVDNQATSLAPGEVVRALDVPAHALRSRVGLQKIALAELGRSGAVVTARVDPHGAAVFVVTAAVRRPRVLRFARVPGAGELRDAVASAPDFYTDPLGSADWRRGVSVVLAERLRAGFARESAGAA
>NC_015125.1|WP_013584408.1|1396319_1396934_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MITAGTTFGSDVDAIDALVADPLALMVQWLPAHDSELRPLAALSTIGLDGIPSLRHVLISDRDAAGLTFHTDEASAKVAEIAANPVAAMAVAWPELGRQLVVRGIVERVTPAEAATVYAQRSRYLQLLAWLNTRENAQLDTSSRQHLWAEFDAAHPTLDPPPRWTGFRLRPLTLTFWRGDPIGQSTRQHYTLADGRWSGQILAG
>NC_015125.1|WP_013584407.1|1395191_1396214_-|methylenetetrahydrofolate-reductase-C-terminal-domain-containing-protein
MTSLPLIDTCPKRMEYGPCGGVGFDGSCEIDAAHRCAFLHRPTVPWTGVDRSSVPASGPRTAAAADTLASLGTRPWVVADLPARALSVASIDACAAVLAGEVDAVLAGDAGSARVQFPPAYRAHLLHQRGLRVWTGLNMRDRNRVAIEGELAALAVEGVAGVHCVTGDHTRTGHRPDAVPVFDLDSTEAASLARAAGHVVSVAASPAAPPVERRAARLREKLRAGADVCFVNHAGGAAPVREFIEEVGAPAAFIPCVPLVVDHASAALLESFTTLVLPDGFLSRVRGAADPRAEGIALAVALAEEMLALPGVVGVNLSGGREGAEESFAEAMAEVARRLR
>NC_015125.1|WP_013584406.1|1394519_1394948_-|SRPBCC-family-protein
MRTLASVTRESSASPSAFYARWVDHDSWREWSPDTEWARVEGEVRRGARGILKPVGGPRTAFEISELEPDRVYTDVSRMPGARLTFRHEVEPTPGGSRLTVLVTLEGPLSWLWARTAFAGFERSVPADLDRLVALVEAVHAR
>NC_015125.1|WP_013584405.1|1394056_1394512_-|winged-helix-DNA-binding-protein
MTTPLDSRFASGDASPGFLLWQVTNRWQAAIRRALAPHEVTHVQFVLLAVLTFADSDQGMTQAALSQRAGADPMMVSQVIRALANRDLVERRQDATDRRAVRVRATAAGRELARAANRAVEEVDEEFFGVDATASHPLVEHLAAVLSRSRA
>NC_015125.1|WP_013584404.1|1391803_1393708_+|FAD/NAD(P)-binding-protein
MSDRATRLVIVGAGPRAVMLVERLLARRTRSPHPHLHVTLVDPHPPGAGRIWRRDQSPLLKLNSMARDVTVFTDETCTIAGPVRSGPSLIEWAERVRAGSLPDVEIDDPDLEAELRTLRGDSFPTRRLQSVYLDWFWRRTVAIAPPGVEVHWHQGAVEWVDDTAEGYEVALADGIRLPAEIVVYALGHNGREPDGETLALIAAAADAGLTYVPPSFTADADLSALGAGDDVIVRGMGLAAVDAIVLLAEGRGGRFSRTPDGTLRYSPSGREPRLHLGSRRGVPYRSKVSSELRGDPPAREVLTPAAVAELLARPGTIDFLDDVWPLIARELVWGHYRELFTGHPERVRVSWDVFRETLREVDGDTAALRRAVAEVVPDPLDRFDVPALDVPLGDEIFADAAEVHRRIRRHIADDLHLRTAPERSTAQALFLTILSSFLALSDIPVERWSARSRAVDLPVTWHTFFSYVASGPPAHRLEEIGALADAGVVRFLGPDVAVGVAEGRFVASSPRVPGDVRAEALVDAWLPGAGAAASDNPALRELATRHGREVHVSDETFSGSLGRIDTDADGRVLARDGVAHETLFAIGPFTAGMEAGAFTRPRSNALSLRITDRVAGAVSEAVAVVSERRWAYPR
>NC_015125.1|WP_013584403.1|1390424_1391807_+|NtaA/DmoA-family-FMN-dependent-monooxygenase
MTRRQIHLAAHFPGVNNTTVWTDPSAGSQIDFSSFEYFARTAERGFFDYLFLAEGLRLREHRGQLHDLDVAGRPNTLSILSALAAVTEHIGLVGTLNTTFNEPYELARQLGTLDLLSNGRAGWNAVTSSDAFHGANFRRGGYLDHADRYVRASEFAALSKALWSSWRDDAIVADAETGAFLRDDAIARVRHESRLFDVDAVFDVPRSPQGRPVIVQAGDSPDGRDFATDHADVIFSLHTEFSDAQQFYRDVKGRLAARGRDEDSLKILPAATFVLGDTAEDARERSREIALQQVRPQTAITYLEQIWNRDLSGYDPEGPLPDVEPDTGVETAQGFAGRHAAIRDRVGQLREQAAAENLTIRELVIRLTAKHTFVGTPEHVASEIDRYVQERATDGFTVVGHVTPHGLDEFTDRVVPLLQERGSYRRSYDEGATLHDLLGLPPVDASAAGAASAPVPAATR
>NC_015125.1|WP_013584402.1|1389237_1390428_+|LLM-class-flavin-dependent-oxidoreductase
MPDRIHLAVALDGAGWHPAAWRETTARPTELTSPAYWRALARTADGAGLLLATIEDALSLGGRSFEPDAETRRDRARGRLDAVLLASFLAPVTRRLGLVPTATTAHPEPFHLATGLQTLDHASRGRAGVRLVAGSTPQERANFGRRADGPTGLPASGRVEDDPALLSAFREAGEVAEVIRRLADSWEDDAIVRDLESGKFLDRERVHNVDFEGEFFSVTGASIVPRSPQGRPLVTALAHQSVPYRFAAEHADLVFVTPADAGAVGGILDELASGEREEPLRVFADLLVLVEETRTEAAAVWNRLQDRAPLTTDARVVVGTADDVVEEIRALTAQGIDGVRLRPARLPADLEAIADRVVPRAAAAGILLPDDGAPTLRERVGLPRLASRYARQEVGA
>NC_015125.1|WP_013584401.1|1387333_1388749_-|FAD-binding-protein
MSVPTAIAASTGLSALLDDVRVEAPDIEVRPPSPATAPFGHDAATAPRRGARAYDGPAVAFPATVSEVQRLVRLAARHGVSVVPRGAGSGLSGGAVASTEQLVISTDRLNRIVEVSPADEVAVIEPGVLNAALNEHLAPLGLFYAPDPASWRISTIGGNIATNAGGLRCAKYGVTRESVLALDVVLADGSLVSIGHRSIKGVTGLDLVSLFVGSEGVLGLVVGATVRIRPLPVARRTVTAFFSSTAEGAAAIGAITASRVRPSVVEFLDEPTLVGIDAANDSGLRARGAALLLIELDGFGIDEQTAELATALEAVGARVQVESDADAEVLWELRRSGRRLGEGTWFVGGDVAVPKSRIAEVFAAFPDIEARYGVAVSAVSHAGDGNLHPVITLPIPAGVDPAAVPAVLHEAAEDLVRRALAVGGTVSGEHGIGTVKRELAAEELAERVRIAQLAIKDALDPAGLFNPGKAL
>NC_015125.1|WP_043362285.1|1400979_1401840_-|PhzF-family-phenazine-biosynthesis-protein
MTPTPGILHLLAFAAEPGGGNPAGVILDARALDDAQMQRIATDLGHPETAFVGEREGRRVAVRYFSPDDEVQFCGHATIATAVALAEAEGVGAYTFETAAGAVEVVTETEGERIIAGFTSVEPHVVDLEDVVADRLLDLLGLTRADLDERMPLAQAFAGNLHPIVAVASRDTFDAFTFEGPRLRALLDERGWKGTATVVHVDGPLGNGAVVEARNLFPVAHILEDPATGSAAAALGAYLRDRAEMPAPFGFTVRQGRHVGRPSILEVEVPASGGIRVSGTAVPLAG
>NC_015125.1|WP_013584412.1|1401883_1402498_-|GrpB-family-protein
MTDDNPAAIAEHRPEWAARAAALLVDVRSALAGLPGAGAAALDHIGSTAVPGLAAKPFLDLQVRIAPLPDEDELLARLAPRGYVRARGSRPDSPGVDRDLPRGRIEVDDVVWEKRLYWHEDAQAILHVRRFDSPWGRYTVWFRDWLRAHPAERDRYARLKQRLSAQQVGKADYDDYTRAKTVFFDEVQAAFEAWAARESRSTNR
>NC_015125.1|WP_013584413.1|1402557_1402926_+|hypothetical-protein
MRIVGGIVLVVVAIVVGLFGALMLGASGLSWAGPGLTVIPYSDSDDGERAIGIGMGVVALGSWALLTLAGFFVARGRTRTRSSRVVAGGLVAVSVVVVVGATIFLTSTPPPVIENPPPWNRA
>NC_015125.1|WP_013584414.1|1402945_1404229_-|allantoate-amidohydrolase
MTTATRLDVAPERVVSAARRVMGRCEELARVTATPGSITRVYLSPEHARVNRLAAEWMRELGMTTRQDAAGNQVGRLAPAGAPDAPTLLLGSHLDTVPDAGRFDGIVGVLMALEVVRLIRSIDDEGTASSPFPFALEVIAFSDEEGTRFGKALLGSSAVAGQWDDAWWDLTDADGSTLREAFREFGLDPGRIGEAARRPEQLVAYLEAHIEQGPELHRSGQALAAVSSIASARRFQLVVEGEARHAGGTPYDMRRDALLGASEAALAVERICRGEHHIIGTVGQLEAFPGAVNVVPGEAHFSLDLRGEFDATRDHTWDEISRELDAIMGRRGLRWRAREVHSAPAVFCAPLLQDVVRAGIGGEAPTLFSRAGHDAMSIGAITEVGMLFLRNPDGISHHPDEAVSGGDVAAGIRALAEAVLHLGAEPR
>NC_015125.1|WP_013584415.1|1404419_1405652_-|alanine--glyoxylate-aminotransferase-family-protein
MSHLPGPIDPPARLLMGPGPISAYPSVLRAMGAPLVGQYDPFMTATMTETQELYRRVWATDNDATLLIDGTSRAGIEAAILSLVRPGDRVLVPVFGRFGHLLAEIAERALAEVHTIEVPWGEVFPVSTIREAIERVKPHLVACVQGDTSTTMLQPLDEIGEICRAHGALFYTDATASLGGNAFEMDAWGLDAATAGLQKCLGGPSGSAPISLSERAVEVVRSRARVEAGIREEGDAVASDFIRSNYFDLAMILDYWGPRRLNHHTEATTMLYGARECARVLLLEGRDAVIDRHRLHGDAMLAGVQGLGLTVFGDVAHKMTNVVAVEIPEAVVGDAVRAELLSDFGIEIGTSFGPLHGRVWRIGTMGYNARTDAVLTTLAALEAVLRRHGASVPAGGGVEAAQGVYAAARS
>NC_015125.1|WP_148272939.1|1405707_1407369_-|DUF3225-domain-containing-protein
MSELATPERVSREPVPNDSAGIPEPAPAAPTNSAAIPADLRSAFDAYERAIVANDLDALDAFFAPGPDTLRGDPAGLLVGHDAISGFRSLRGGVPPRDITDIHYRRLGPDVALLMSVSRFHGGGRGLQTQVWQRIDGRWLITAAHVAPRTPPLDRSIWRSVGDPFLQGAWEGTLAGLTVAVKDLFAIAGFRIGAGNPAFLEEARPEKVTAPAVADLLRAGASLRGIARTDEFAYSIAGDNVHYGTPPNGAVVGALPGGSSSGPASAVAAGHADIGLATDTAGSIRVPASYQGLWGLRTTHDLVPRQGMLPLAQSFDTIGWLTRDGDTLQRVADWCLSYDGSATTENVYGASGDDLPWRFLVPEEILECAEPATREAFSKLVAALAASDDPPPFRAVHTGDLDAAFAAFRTVQGAEAWRNNGEWMTAHPGAVGPAVAERFSVASRIAAADEAAAREDLEPIAAHLAELVDGAVLIFPTVPGPAPQRTADVDAVRAATLRMTAPAAIAGLPSISVPLLTVDGAPVGLCLVSRAGTDIALVRLARRLAALVEGGLR
>NC_015125.1|WP_167539382.1|1407574_1408867_-|acetamidase/formamidase-family-protein
MAASGVPELVEGTGHARSGGGFDRLSHHGRAPSGIPTPFPILQPGTGPIPGDHYLRATPETVLWGRLPCATDTPVLEIASGETVTIDTVSHEGILDDQGKDPAAYFSAHGVPRAQVLDDAVEIAASVLRDPRADGPHVVVGPVRVAGAHPGDLLKITVETLVPRVPYGVISNRHGKGALVGELPRGEHNVSVFSAVAEREGVLHGTLPLREGGDPLVAFPLAPFLGTMGVAVAGDERPHSVPPGTHGGNIDINLLVEGTALFLPVQVDGALAYVGDPHFAQGDGEVALTALEASLRATLRFEVVPAEAARAAFGEVVGPLVRTPEYLVPTGMDPDLDAAMRACVRSSLALLGGRWGMGEHLAYAYLSAATDFDISQVVDIVSGVHARIREADFAGVPAVEPEALASGTAAVSMPAPVDGAAANEQEGDVA
>NC_015125.1|WP_043361117.1|1408938_1410273_-|allantoinase-AllB
MSTRIAARRVYLDGEFRPATVVSEGGTITSVEPFDAAAETVLPGDSVLLPGLVDSHVHLDEPGRTEWEGFATGTAAAAAGGVTTIVDMPLNSSPVTTTLPALDAKRAAAAGKLAVDVAYWGGAVPENLGSLRALSDAGVVGFKCFLSPSGIDEFGHLDAEQLERCLAELAVFDGLLIVHAEDPAHLHADGALGPRYRDFEASRPPLSERSAILRVIDAARRTGARAHIVHVADGGALDDVRAAKAEGVRLTVETCPHYLTLDAAEVPDGAGAFKCCPPIRGGDNRDLLWAGIVDGTIDAIVSDHSPATVELKSNPDFGLAWGGIAGLQTGLSAVHSTARARGLAFESLLPLMTTGPARIAGLEGLGVIAPGAPAHLVAFAPDEEFVVDATALEYRNPVSPWHGQTLTGVVRETWLRGESVYRRGSAVTERGGREILRATAAVDA
>NC_015125.1|WP_148272941.1|1410324_1411038_-|aspartate/glutamate-racemase-family-protein
MTAKIAEAAREVAGPDVLIEAVCPATGAAAIESHTDEVLAAAAVVELVAADRDGLDPADAYVIACFGDPGLDAARELVEAPVVGIAEAAMHLAAVSGRHFGVVTTLSRTLGRARDLVSRYGMERACVSLAATGIPVLDLEDTGSVAVETIARYSAEAAAAGADVIVLGCAGMADLCVELTARVGVPVVDGVAAAVGVASGMARMGLGTSKRDEYALPTREGAAPTLPPQATNLEVFA
>NC_015125.1|WP_013584421.1|1412996_1413632_+|helix-turn-helix-transcriptional-regulator
MTQPPLADAVDPDAAVPGAPAEPAASVGARIRDLRQARGISARALAATLGISPSAVSQIERGVMQPSVSRLIAITDALGVPLVAAFDPASDRPVEPVGPSGFTLQRAAQAADIVLESGVSFRRLTPGSSPGVDYFESVYPPGASAHGADGLFHHEGYEVGTVVAGELTIDFEAERVILRAGDAISYPCSVPHRLHNTGATDAVAHWLIVHA

Crispr_ID: NC_015125_6

• CRISPR_ID: NC_015125_6
• CRISPR_location: 1462019-1462116
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of NC_015125_6

Consensus_repeat	Method
CCGGGCCGAACTCCCGAGAAACCG	CRISPRCasFinder

spacers of NC_015125_6

>6.1|1462043|50|NC_015125|CRISPRCasFinder
CGCCGGCCACCAACCCCGCCGACGCCGCGGGCACTCGGGCCATCCGCCCA

CRISPR arrays and Neighbor proteins around NC_015125_6

CRISPR arrays

The CRISPR arrays of NC_015125_6

>merge|NC_015125|6|1462019-1462116|CRISPRCasFinder
CCGGGCCGAACTCCCGAGAAACCGCGCCGGCCACCAACCCCGCCGACGCCGCGGGCACTCGGGCCATCCGCCCACCGGGCCGAACTCCTGAGAAACCG

>NC_015125|6|5|1462019-1462116|CRISPRCasFinder
CCGGGCCGAACTCCCGAGAAACCG	CGCCGGCCACCAACCCCGCCGACGCCGCGGGCACTCGGGCCATCCGCCCA
CCGGGCCGAACTCCTGAGAAACCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013584462.1|1463164_1464406_+|SufS-family-cysteine-desulfurase	unknown	unknown	gnl|CDD|131034
NC_015125.1|WP_074696280.1|1453967_1454057_+|K(+)-transporting-ATPase-subunit-F	unknown	unknown	unknown
NC_015125.1|WP_013584455.1|1454060_1455728_+|potassium-transporting-ATPase-subunit-KdpA	unknown	unknown	gnl|CDD|377138
NC_015125.1|WP_148272827.1|1453758_1453971_+|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013584464.1|1465070_1465505_+|hypothetical-protein	unknown	unknown	gnl|CDD|227933
NC_015125.1|WP_013584453.1|1453181_1453619_-|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl|CDD|181730
NC_015125.1|WP_013584456.1|1455727_1457923_+|potassium-transporting-ATPase-subunit-KdpB	unknown	unknown	gnl|CDD|234905
NC_015125.1|WP_013584457.1|1457934_1458519_+|potassium-transporting-ATPase-subunit-KdpC	unknown	unknown	gnl|CDD|376890
NC_015125.1|WP_013584460.1|1462323_1462800_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_043361123.1|1450251_1452345_+|APC-family-permease	unknown	unknown	gnl|CDD|223605
NC_015125.1|WP_043362334.1|1458779_1461308_+|sensor-histidine-kinase-KdpD	unknown	unknown	gnl|CDD|225115
NC_015125.1|WP_043361125.1|1452555_1452942_+|PLDc-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|379161
NC_015125.1|WP_013584467.1|1467271_1467778_-|DUF4304-domain-containing-protein	unknown	unknown	gnl|CDD|379489
NC_015125.1|WP_043361132.1|1469513_1470983_+|hypothetical-protein	unknown	unknown	gnl|CDD|236310
NC_015125.1|WP_013584468.1|1468105_1469047_+|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl|CDD|227259
NC_015125.1|WP_013584466.1|1466637_1467036_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
NC_015125.1|WP_013584459.1|1461304_1461976_+|response-regulator	unknown	unknown	gnl|CDD|223816
NC_015125.1|WP_043361129.1|1469142_1469415_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|238042
NC_015125.1|WP_013584463.1|1464402_1464858_+|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl|CDD|273918
NC_015125.1|WP_013584465.1|1465640_1466618_-|SRPBCC-domain-containing-protein	unknown	unknown	gnl|CDD|176868

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_015125.1|WP_013584466.1|1466637_1467036_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	6.5e-13	43.8	0.4

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013584462.1|1463164_1464406_+|SufS-family-cysteine-desulfurase	gnl|CDD|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NC_015125.1|WP_013584466.1|1466637_1467036_-|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	5.93115e-12
NC_015125.1|WP_013584455.1|1454060_1455728_+|potassium-transporting-ATPase-subunit-KdpA	gnl|CDD|377138	pfam03814, KdpA, Potassium-transporting ATPase A subunit.	0
NC_015125.1|WP_013584467.1|1467271_1467778_-|DUF4304-domain-containing-protein	gnl|CDD|379489	pfam14137, DUF4304, Domain of unknown function (DUF4304). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 223 amino acids in length.	1.39897e-27
NC_015125.1|WP_013584464.1|1465070_1465505_+|hypothetical-protein	gnl|CDD|227933	COG5646, COG5646, Uncharacterized conserved protein [Function unknown].	9.63706e-05
NC_015125.1|WP_013584453.1|1453181_1453619_-|aminoacyl-tRNA-hydrolase	gnl|CDD|181730	PRK09256, PRK09256, aminoacyl-tRNA hydrolase.	3.33078e-53
NC_015125.1|WP_013584456.1|1455727_1457923_+|potassium-transporting-ATPase-subunit-KdpB	gnl|CDD|234905	PRK01122, PRK01122, potassium-transporting ATPase subunit KdpB.	0
NC_015125.1|WP_013584457.1|1457934_1458519_+|potassium-transporting-ATPase-subunit-KdpC	gnl|CDD|376890	pfam02669, KdpC, K+-transporting ATPase, c chain. This family consists of K+-transporting ATPase, c chain, KdpC. KdpC forms strong interactions with the KdpA subunit, serving to assemble and stabilize the Kdp complex. It has been suggested that KdpC could be one of the connecting links between the energy providing subunit KdpB and the K+-transporting subunit KdpA. The K+ transport system actively transports K+ ions via ATP hydrolysis.	4.58414e-89
NC_015125.1|WP_043361123.1|1450251_1452345_+|APC-family-permease	gnl|CDD|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	8.68862e-29
NC_015125.1|WP_043362334.1|1458779_1461308_+|sensor-histidine-kinase-KdpD	gnl|CDD|225115	COG2205, KdpD, Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms].	0
NC_015125.1|WP_043361125.1|1452555_1452942_+|PLDc-N-terminal-domain-containing-protein	gnl|CDD|379161	pfam13396, PLDc_N, Phospholipase_D-nuclease N-terminal. This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, pfam00614. However, a large number of members are full-length within this family.	4.68433e-10
NC_015125.1|WP_043361132.1|1469513_1470983_+|hypothetical-protein	gnl|CDD|236310	PRK08601, PRK08601, NADH dehydrogenase subunit 5; Validated.	1.13649e-45
NC_015125.1|WP_013584468.1|1468105_1469047_+|nuclear-transport-factor-2-family-protein	gnl|CDD|227259	COG4922, COG4922, Uncharacterized protein conserved in bacteria [Function unknown].	1.74955e-12
NC_015125.1|WP_013584459.1|1461304_1461976_+|response-regulator	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.78335e-75
NC_015125.1|WP_043361129.1|1469142_1469415_-|MarR-family-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	6.20117e-07
NC_015125.1|WP_013584463.1|1464402_1464858_+|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl|CDD|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	6.09818e-45
NC_015125.1|WP_013584465.1|1465640_1466618_-|SRPBCC-domain-containing-protein	gnl|CDD|176868	cd07826, SRPBCC_CalC_Aha1-like_9, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	9.1076e-38

Protein sequences

>NC_015125.1|WP_013584459.1|1461304_1461976_+|response-regulator
MKVLIADDDPQLVRALRITLAAHGYDVVAAADGAAAITLAAGSHPDIVLLDLGMPHLDGVQVIQALRGWTSVPIIVVSGRTGSADKVDALDAGADDYVTKPFQIDELLARLRVHARRSAPASGEAVVRFGSVEVDLAAKAVLRDGTRVHLTPTEWRMLEFLARNPGSLVTRQTLLKEIWASEQVADSGYLRLYMSQLRKKLEADPSNPVHLLTEQGMGYRLVV
>NC_015125.1|WP_043362334.1|1458779_1461308_+|sensor-histidine-kinase-KdpD
MRRGTLRVLLGMAPGVGKTYEMLEEGRRLAAEGRDVVIAVVETHGRAATAAQAEGLEVVPRRPVAHRGVALDEMDLAAVIARHPDLALVDELAHTNAPGSANDKRWTDVEELLDAGIDVITTVNVQHIASLNDVVEKITGVTQRETVPDAVVRAADQIEVVDLAPQSLRDRLSAGFVYPAERIDAALSNYFRLGNLTALRELALLWLADEVDSALQRYRTEHGIEGSWQARERVVVALTGGSEGETLLRRGARIAARSAGGELLAVHVSTQDGLRTSNPAALETQRALVEQLGGTYHQVVGDDVATALVDFARSVNASQLVIGVSRRGRLGAALTGPGIGNTVIRESGDIDVHIVNHARAGGRFALPRLTGPALSMKRRILGFVTALVGGPIISLLLLATGSDDSITTDVLSYQLLVVIVALIGGIWPAVFAAVLSGLTLDFLFIAPLHTVTISDPVHAIALVLYVVIAMLVSVVVDQAARRARAARRASAEAELLATVAGSVLRGEVAVPALVSRAREAFGLAGVRLIAADGRVLATDGEPVRDDRRTTVPVGDGRATLELHGGDLDAGARRLLDVVVAQLAAALERADLAETAAEAGALAETDQVRSALLSAVSHDLRRPLASAVAALGGLRAAGDHLSEDDRRELIETADESLATLSVLVTDLLDVSRVQAGVLAVSLAPVDAADVVIAALDELDLGPDEVELALDPDLPSLRADAVLLQRVLVNVLANAQRYTPEGVRVRIATSRLGGIAEIRVIDHGPGIAVERRDDMFSPFQRLGDTDNTAGLGLGLALSRGFAEGMGGTLVPEDTPGGGLTMVVTLPVAEGGAEAVASGIREDAP
>NC_015125.1|WP_013584457.1|1457934_1458519_+|potassium-transporting-ATPase-subunit-KdpC
MRTTLRTAGVAVRAMLVFTVVLGVGYMLFITAIGQVALPFQANGSLVRSADGTVTGSQLIGQSFQDADGQALPQYFQSRPSAASYDGAASTGSNLGPENPDLIASIQQGQSDFRALNDDGSVPADAVTASGSGLDPDISVENAERQVARVAEARGIPASEVSALVAEHTLPRDLGYLGEPRVNVFELNRALDAR
>NC_015125.1|WP_013584456.1|1455727_1457923_+|potassium-transporting-ATPase-subunit-KdpB
MSTLISSPASQPAPEPVEGSGAPTDPPRRAFSAAQIVAALPGAAKKLNPAAQWRNPVMFLVWVGAALTTLIALAEPFLGDASTGSASESLPFGFTWGIAVWLWLTVFFANIAESVAEGRGKAQAATLRKTRTTTSARRVVSYSPADPAASGAATEDVPSGDLRVGDIVLVETGELIPGDGDIVHGIATVDESAITGESAPVVRESGGDRSAVTGGTRVLSDRIVVRITSKPGETFVDRMITLVEGASRQRTPNEIALNILLASLSIVFVVVVLVLNPIASYAASPVSIPVLVALLVCLIPTTIGALLSAIGIAGMDRLVQRNVLAMSGRAVEAAGDVTTLLLDKTGTITYGNRRASAFVPLNGVGGPMLAEYASMSSQADPTPEGVSVVELASAQGIVAEMPRGAESVPFTAQTRMSGLDLPDGTQIRKGAASAVLAWLDGSHAEVPEATRAELLNSANAIAESGGTPLVVATLTPSTSGVSHVPAQVLGVIHLKDVVKDGLRERFQELRAMGIRTVMITGDNPLTAKAIAAEAGVDDYLAEATPEDKLALIQREQEGGNLVAMTGDGTNDAPALAQADVGVAMNTGTSAAKEAGNMVDLDSDPTKLIDIVRIGKQLLITRGALTTFSLANDIAKYFAIIPAMFMGVFPGLAVLNIMQLSSPASAVLSAIIFNAIVIIALIPLALRGVKYRAASASSILSRNLLVYGLGGVLVPFIGIKLIDLVVSLLPGF
>NC_015125.1|WP_013584455.1|1454060_1455728_+|potassium-transporting-ATPase-subunit-KdpA
MSIVLTSLTLLVALGLAYRPLGDYIARIYTGRRDLAVERGTYRLIGVDPRSAQTWAAYLRSVLLFSFVGVVLVYALMRLQAVLPFSLGLGAPSEALSFNTAVSFVTNTNWQSYGGESTLGYTVQFAALTVQNFVSAAVGIAVAVALVRGFAYRRSGVIGNFWVDLVRGTFRLLLPFSVVAAVVLLAGGVIQNLNGFTDATTLTGAAQSIPGGPVASQEAIKLLGTNGGGIFNANSAHPFENPTPWTNLFEIFLMLVIPFSLPRAFGRIVGDDRQGYTILGVMGAIFVASTALLTWAEMAGAGTAPMLAGGAMEGKEVRFGIFGSTLFGTTSTLTSTGAVNSMHDSYTALGGMMPMVNMMLGEIAPGGVGSGLYGMLILAVIAVFVGGLLIGRTPEYLGKKIGPREIKLASLYILVTPTLVLAGTALSFGIPGIRSDVESTSILNPGVHGLSEVLYAFTSAANNNGSAFAGLTANTPWFNTALAVAMLLGRFLPIVFVLALAGSLAAQDAVPATAGTLPTHRPQFAGLLAGVSVIVTALTYFPVLTLGPLAEGLVR
>NC_015125.1|WP_074696280.1|1453967_1454057_+|K(+)-transporting-ATPase-subunit-F
MIFFSILAAVLAVAAVVYLVVALVRPEKF
>NC_015125.1|WP_148272827.1|1453758_1453971_+|hypothetical-protein
MDRHTCRPAAPAARPRFCLDPGVVVLDAVFLAATVALFALVALVAKGVEKLGPEARPSSARPAGRGGDRS
>NC_015125.1|WP_013584453.1|1453181_1453619_-|aminoacyl-tRNA-hydrolase
MSASDDPGIRVTGSLVIPASELSWRFSRSSGPGGQGVNTTDSRVELMWDAGASTVLSPVQRERLIDRLGNRLVGGVLTIAASEHRHQVRNRDAARERLAALVADAVRAPAPPRRATKPTRGSTERRLQAKQRRTDVKRMRRRPTD
>NC_015125.1|WP_043361125.1|1452555_1452942_+|PLDc-N-terminal-domain-containing-protein
MPLLALLTLAVMVIALIDAITRRDDQVKHMPKFVWVFFIVLLPLIGSILWFTIGREYEQRSAPMSFGDPRRWQKDADPAPAPRTYDSRSTEQQIADLEREMHLADLEEQVRRRRAEGGGAGSGAGAGS
>NC_015125.1|WP_043361123.1|1450251_1452345_+|APC-family-permease
MSRAVTEESREPGVETPMAKRILIGEPLTSEKLDEQLLPKKMALPIFASDALSSVAYAPQELLMILLIGGTALLTLSPWVAVAVVTLLVVVVLSYRQLIKAYPSGGGDYEVASKNLGEVPGVIVAAALLVDYVLTVAVSVASGVDNIISALPELNPFRVEIAVGFVILIVIVNLRGVREASSVFAIPTYLFIGSVGIMIVVGLGRTLLGNAPVAESAQYAVQAESLTQAALILLVLRAFSSGCSALTGVEAVSNGVPAFRMPKIRNAQTTLTMMGGIAIVLFAGLTILALISGVHYAENPCHLIGFDCANNPQPSLMAQVAAATFGMGSIPFFIIQAATACVLLLAANTAFNGFPLLGAVLARDGYAPKALNTRGDRLVYSNGMIILGIVAIGVLIVYQANLTTLIQLYIIGVFVSFSLGQIGMVKHWRRALRGLKDLPPEAAKQQSAAIERRSAISGLWINSIGAGMTVLVLLIVTITKFTHGAWLVFIAIPILAVLMLGVNRYYRDVEHEIQMDDTVHFGASGDVAIVLVNRLQKPVMKAIDYALAAKHDKTLAVHVAITDEESAKLQKEWDEHDMPIPLVIIESPYRTYTSPVSSFIKSYREKHGSSVVTVYLPQFIVGHWWESILHNRRSRRLAQQLMLVHGVSITLVPWLLDSSEVIYGRRSRPLPGQQRGGQPVAQVPARPARKTPGDSAS
>NC_015125.1|WP_013584460.1|1462323_1462800_-|hypothetical-protein
MTLTALLPTLRASIPAPFDAAAWPAGSAPTLDDVTVRAVSVGRYAEICGTPCVCTGPAVIPASGGVASASLSTTVVVATVTDATPATLRLDACVAGLEVVWREARLIGRVSHAYDEPFVVLDAHGSAACGTVVLPGDVRVGDRVAFPCPGCHTVGEVR
>NC_015125.1|WP_013584462.1|1463164_1464406_+|SufS-family-cysteine-desulfurase
MTLPFDVDAVRADFPILETEVDGHPLVYLDSGATSQKPRAVLDAERDFLEHANSAVHRGAHTLAAEATELFEDARATVAEFVGAQPEQLVWTSGATAGLNLVAGSLGYAGRLREGDEIVVTEAEHHANLIPWQELAARTGARLRHIPVLEDGTLDMRAAADLIGERTRVVAFPHVSNVLGIVNPVAKLVTLARGVGALTVLDACQSAPHLALDLPASGVDLAVFSGHKVYGPYGIGALWGRDEVLESLPPFTTGGSMITTVTLEKAEYLPPPQRFEPGTQPVSQAVGLAAAVRWLGEHDLAAAHAHEATLEKRMREGLRSIPGVRLLGDTDAADRVALQAFAVEGVHAHDVGQFLDSRGVAARVGHHCAQPLHRRFGLTATVRASAAIHTTAAEIDTFLDAVSGVRGFFGVGA
>NC_015125.1|WP_013584463.1|1464402_1464858_+|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MSGLESLYQELILDHAKNRRGFGLAEPGAHSATVHQRNPVCGDEITLRVDVEGDRVVSVTWEGAGCSISQASASMLVALLQEDGGDEGMPRADVEALIAAFREALRSRGKTPLDEETFADAAALSGVSKYTARVKCAMLAWVALEEGLRQA
>NC_015125.1|WP_013584464.1|1465070_1465505_+|hypothetical-protein
MGNGFSAEERAAMKQRAEELQAMKGLKGLAKLQKENEACLEAIEKLEGADRSIAERVHVIVLEEAPHLNPKTYYGFPAYAKDGKVVVFYQPASKFKTRYGTVSFDETAQLDDGPMWPVSFAVLDVTAEVEQRIRELVRRAAPAA
>NC_015125.1|WP_013584465.1|1465640_1466618_-|SRPBCC-domain-containing-protein
MPVTSVESDTEALTMTLVADFPVDPERLWAVFTDPRQLERFWGPPGWPATFASFAFERGGRARYSMASATGEIARGSWEFLDIDAPRGFEVVDSFVDETGEAIPGMPAMRMTFAFDETEGGSRLTNVTYFDSAEALEQLIAMGAVEGSTLAMNQLDVVLAGLREFAQGKGTQLEILDDQHVRITRLIEGPRELVWRAHVEPDLMRQWMLGPDGWRMSVSDVDLSVGGKYRIAWEPEPGTEGEGFGFDGETLLLDEPRRIVQTEHMTGTDWPSTTNDLSFYEEDGATLVTLLIEYPDAATRDAVLATGMVDGMEKSFERMERVVIG
>NC_015125.1|WP_013584466.1|1466637_1467036_-|winged-helix-turn-helix-transcriptional-regulator
MVKQQPLADADIDRVFHALADATRRDIVRRTLVAEQSVSDLAAGYAMSFAAVSKHISVLAEARLITKRAEGRVRLVRADPAALARAQNLLRSYEDLWRGRIDRLDALLAEPAPAGPRREDAGVPASVPPSVN
>NC_015125.1|WP_013584467.1|1467271_1467778_-|DUF4304-domain-containing-protein
MPLTSESFWPWRLRSRGKATVAAQIPAQDLYAAMIKDTISPALRAEGLIGSGGRYSVKSDTHWALVGFQKSAYSDRREIQFTVNLMVVRRDEWLAQAAENSYFPVKPSASMGYGSVMPKRIGSLVGDGADKWWRLFGGQDVDLLAADVLTDLRDAGLPWLRERVAATS
>NC_015125.1|WP_013584468.1|1468105_1469047_+|nuclear-transport-factor-2-family-protein
MPLIDSRHLTRTAALVAGAVVVAGLALAAPATAATPATGSTAQVTDAGNRLDAGTEHRNTCVIRTLFAATFDDPRSEFSQKLAKWFVAPDAVAHGAGAASGPQGLLAQFAADRDRVPGARAVIKHIAADGDLVAVHWQIAPDPSDERRGDAAVDLFRLRGGRVVERWSLEQAIPTGTPASGNTNTMFSDLYHPSEPTPTPTEEQEEQNRVFAVSAYETLFRDKDVSILDRAFDPAYLQHNSVAPNGTAALKQFFLSGIPFPAQQSVISLSDGDIVWTFSQAVGAKPGDPLLAADLFRVDGGLIREHWDVVPTS
>NC_015125.1|WP_043361129.1|1469142_1469415_-|MarR-family-transcriptional-regulator
MNTWTFLTNHAHVFIYVARDPGARVREIADAVGITERTAHGILADLVEAGYLKREKEGRRNRYECVEDLPMRHPVESDHPVGALLEALKG
>NC_015125.1|WP_043361132.1|1469513_1470983_+|hypothetical-protein
MSPLAPLLTAALLAAVIAALLPDATRHRTPGSLAVWPGVAAAALATLGLAGALAERTDVAGAALALLIVALTVVVQVYASRNLRGDPRARSFFALSLLAALGSTTAIAADDVVLLAVGWTLSTLSVIALIASGGSGPQTRIAVRRSAVALLIGDAALWAAVVVATASTGSISLAALGSLEGTSAALVGALVAIAAIARAGSFPLHGWLPATAATTTPVSALLHAGFVNAGALLLLRFSAVPSDLGPWIAGIAGAITLVVATLAMLTRADVKGRLVHSTAAQMGFLLLACALGAYGLAFVHVIGHALFKASLFLGAGSAVEHALRERALPRPTPSRVGGVVGTAVVLAAAAIAVAASDAFAHPPAALLLFAITTATVAGARIGASSARVSTRAGLLLTLALAVVGYVAVVFPGAEALVPVAGAAVLPWGVTVAVFLIAAASLLAIRSARPLSDRIFAFALAWGRPPLGAPTTPSWASASAGGPLEYRRVS

Crispr_ID: NC_015125_7

• CRISPR_ID: NC_015125_7
• CRISPR_location: 1909246-1909371
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_7

Consensus_repeat	Method
CGGCGGAGGTGGCTGAGCTTGTCGAAGCCTCCGGTCCCTTCGA	CRISPRCasFinder

spacers of NC_015125_7

>7.1|1909289|40|NC_015125|CRISPRCasFinder
TGGCCTCCGGTCCCTTCGACGGGCTCAGGGACCTGGGTTG

CRISPR arrays and Neighbor proteins around NC_015125_7

CRISPR arrays

The CRISPR arrays of NC_015125_7

>merge|NC_015125|7|1909246-1909371|CRISPRCasFinder
CGGCGGAGGTGGCTGAGCTTGTCGAAGCCTCCGGTCCCTTCGATGGCCTCCGGTCCCTTCGACGGGCTCAGGGACCTGGGTTGCGGCGGAGGTGGCTGAGCTTGTCGAAGCCTCCGGTCCCTTCGA

>NC_015125|7|6|1909246-1909371|CRISPRCasFinder
CGGCGGAGGTGGCTGAGCTTGTCGAAGCCTCCGGTCCCTTCGA	TGGCCTCCGGTCCCTTCGACGGGCTCAGGGACCTGGGTTG
CGGCGGAGGTGGCTGAGCTTGTCGAAGCCTCCGGTCCCTTCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013584873.1|1902711_1903344_-|hypothetical-protein	unknown	unknown	gnl|CDD|99750
NC_015125.1|WP_013584886.1|1916330_1916903_+|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223508
NC_015125.1|WP_043361244.1|1905999_1907361_-|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|237233
NC_015125.1|WP_013584872.1|1900452_1902660_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|274529
NC_015125.1|WP_013584888.1|1918379_1918808_-|hypothetical-protein	unknown	unknown	gnl|CDD|226318
NC_015125.1|WP_013584869.1|1896190_1897414_+|glycosyltransferase	unknown	unknown	gnl|CDD|340844
NC_015125.1|WP_013584887.1|1917088_1918333_-|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|227277
NC_015125.1|WP_148272955.1|1897835_1898786_+|glycosyltransferase-family-4-protein	unknown	unknown	gnl|CDD|340831
NC_015125.1|WP_043361248.1|1914927_1916187_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NC_015125.1|WP_013584881.1|1910526_1911684_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013584878.1|1907463_1909236_+|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl|CDD|225922
NC_015125.1|WP_013584874.1|1903565_1903832_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NC_015125.1|WP_013584876.1|1905199_1905784_-|nitroreductase-family-protein	unknown	unknown	gnl|CDD|380315
NC_015125.1|WP_013584884.1|1914266_1914935_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NC_015125.1|WP_013584871.1|1899039_1900029_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|181818
NC_015125.1|WP_013584882.1|1911986_1913111_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224582
NC_015125.1|WP_013584875.1|1903828_1905145_+|HipA-domain-containing-protein	unknown	unknown	gnl|CDD|341492
NC_015125.1|WP_013584883.1|1913107_1913992_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|226631
NC_015125.1|WP_013584879.1|1909436_1910123_+|hypothetical-protein	unknown	unknown	gnl|CDD|236507
NC_015125.1|WP_013584880.1|1910138_1910519_+|VOC-family-protein	unknown	unknown	gnl|CDD|319925

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013584873.1|1902711_1903344_-|hypothetical-protein	gnl|CDD|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	0.000999217
NC_015125.1|WP_013584886.1|1916330_1916903_+|NAD(P)H-dependent-oxidoreductase	gnl|CDD|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	2.96557e-40
NC_015125.1|WP_043361244.1|1905999_1907361_-|glucose-6-phosphate-dehydrogenase	gnl|CDD|237233	PRK12853, PRK12853, glucose-6-phosphate dehydrogenase.	0
NC_015125.1|WP_013584872.1|1900452_1902660_+|AAA-family-ATPase	gnl|CDD|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NC_015125.1|WP_013584888.1|1918379_1918808_-|hypothetical-protein	gnl|CDD|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	2.40331e-28
NC_015125.1|WP_013584869.1|1896190_1897414_+|glycosyltransferase	gnl|CDD|340844	cd03817, GT4_UGDG-like, UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.	3.2899e-83
NC_015125.1|WP_013584887.1|1917088_1918333_-|RNA-polymerase-sigma-factor	gnl|CDD|227277	COG4941, COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription].	1.23096e-138
NC_015125.1|WP_148272955.1|1897835_1898786_+|glycosyltransferase-family-4-protein	gnl|CDD|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.6968e-24
NC_015125.1|WP_043361248.1|1914927_1916187_-|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.394e-39
NC_015125.1|WP_013584883.1|1913107_1913992_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|226631	COG4152, COG4152, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	1.75538e-95
NC_015125.1|WP_013584878.1|1907463_1909236_+|glycoside-hydrolase-family-15-protein	gnl|CDD|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	1.10501e-121
NC_015125.1|WP_013584874.1|1903565_1903832_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.34679e-07
NC_015125.1|WP_013584876.1|1905199_1905784_-|nitroreductase-family-protein	gnl|CDD|380315	cd02138, TdsD-like, nitroreductase similar to Burkholderia pseudomallei TdsD. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.	4.61946e-70
NC_015125.1|WP_013584884.1|1914266_1914935_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.51048e-74
NC_015125.1|WP_013584871.1|1899039_1900029_+|helix-turn-helix-domain-containing-protein	gnl|CDD|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	3.06418e-123
NC_015125.1|WP_013584882.1|1911986_1913111_-|ABC-transporter-permease	gnl|CDD|224582	COG1668, NatB, ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism].	1.05625e-20
NC_015125.1|WP_013584875.1|1903828_1905145_+|HipA-domain-containing-protein	gnl|CDD|341492	cd17793, HipA, type II toxin-antitoxin sytem toxin HipA and similar proteins. This family contains type II toxin-antitoxin (TA) system HipA family toxins similar to Escherichia coli and Shewanella oneidensis HipA, which is a serine/threonine-protein kinase that phosphorylates Glu-tRNA-ligase (GltX), preventing it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. HipA is the toxin component of the HipA-HipB TA module that is a major factor in persistence and bioflim formation; its toxic effect is neutralized by its cognate antitoxin HipB. HipA, with HipB, acts as a a corepressor for transcription of the hipBA promoter. Structures of HipAB:DNA complexes from both Escherichia coli and Shewanella oneidensis reveal distinct complex assembly.	1.73389e-70
NC_015125.1|WP_013584879.1|1909436_1910123_+|hypothetical-protein	gnl|CDD|236507	PRK09424, pntA, Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha.	0.00721564
NC_015125.1|WP_013584880.1|1910138_1910519_+|VOC-family-protein	gnl|CDD|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.60139e-08

Protein sequences

>NC_015125.1|WP_013584878.1|1907463_1909236_+|glycoside-hydrolase-family-15-protein
MTTPIEDYAVLSNCRSAALVSRDGSIDWLCLPRYDSGSMLGALLGDGSHGRWSLRPADPAARATRRYDGDTFVLVTRWETETGVADVYDAMPVDEGVEAVIRRVVGVSGEVDFVSEVRLRFDYARAVPWVQQIGQGGEHAILAVAGPDAVVVRGPRLIAVDTAHRGRWTTAAGQSVDSVLSWGASWQEPPAPFNVEAALERTREWWAAWADRVQSAGTHAALVTRSLMVLRALTHSETGGIVAAATTSLPEAFGGSRNWDYRYVWLRDAALTLSAYIDHGYLDAAQHWRTWLLRAIAGDPADVQIMYGIAGERDLPEREIPSLPGYGGAAPVRIGNGAVTQYQADVIGEVMVALEAARNAGVEETTFSWSLQRALLNQLAGEVDKPDLGIWEMRGEPHFFTHSRAMVWAAFDRGIRAVEEGGHDGEVDTWRTLRDKVRADIDARGVHDGGWFTQHFDTDEVDASLLVLPQVGFCAYDDPRMLATVARMEETLMPDGWLLRYRTTGVDGLSGDEHPFLACSFWLVGQYAHSGRRDEAVALMKRLTAVANDLGLLSEEYDPTTGRQAGNTPQALSHLALVGAADALDATAAG
>NC_015125.1|WP_043361244.1|1905999_1907361_-|glucose-6-phosphate-dehydrogenase
MAADTTLIILGASGDLTSRLLLPALGQLLAREPGRSVRLHGAGMDDWTDEHWREVVHQAFQTMDADAAFDQVSATTYSQADITKAADLLTLLDAAEGRPALYFAVPPAVTEKSCIALADVNIPEGTILALEKPFGTDEASAHKLNQQLATLVPESQVFRIDHFLGRSTVLNLLGVRFANRLIESVWSADDIATITVDFPEKLGLEGRAGYYDSAGALVDMIQSHLLQVMAFVTMEPPSSLDQLDLRDATAAVLRATHVLDDDPVANSRRARYTAGDVGDRHFVSYVDEPGVDPSRDTETLAEMTVEVRTTRWQGVPITLRSGKALDAGDPAVTVTFKPVRHLPTGFVGESEPSKLVFSLGPDTMSLELNVNGADDPLELERVALAADLGEGALKAYGEVLSGILDGDAMLAVRGDAAEQCWRIVQPVIDAWRQNKVPLDEYPAGSTGPASWQG
>NC_015125.1|WP_013584876.1|1905199_1905784_-|nitroreductase-family-protein
MSLVLDRTAPTDAPILDVLAERWSTRVFDPETPIDETALRSALEAARWAPSGMNHQPWRFLLARRGSDAHQRIVSALMGFNQAWAPAAGALLVVLAETETAEGEARPWALYDAGQAAAHFTVQAHAEGLATHQMGGFEADALRAAFDIEPRFVPVTVIAVGTLGDVDAAEEGLRQRELAPRERRTVADSLLVDA
>NC_015125.1|WP_013584875.1|1903828_1905145_+|HipA-domain-containing-protein
MTVDRVPVVLYGTMIGHLTREGSRAVLRWSAEAEQRWGLRSRVLSASLRVGEESADLSESFFGALLPEGEHIARLARDVKVDRGDLIGLLAEVGADLAGALRISGAAADPRREPERLSAAEVSALLDRADGFLLGGGGSALPGFQRKLTLTRGDGGWIRGNGVLPSTHILKPVGPDARSAVEAEAYALAVARHAGLTTMDSWVEQIGARWVLVIERYDRRLVGTQIERLHQEDAAQALGIPWGGNEKFEENDSRVSLRAVAGLLDRGGNLFAERDADKRRLLRYVAFNVAMGNTDAHAKNFSLLHDDSGATSLAPIYDVAPLALAYGATTRLSMWVDGVQHLPEVTREDLVAEGRSWGLKDAVATAAVDETLSAMVEATRRLPAHDSIEAHVPGYVRGQAQDLLDGEPARIASHLPLMLRERLGAPQPRGDASAEPSR
>NC_015125.1|WP_013584874.1|1903565_1903832_+|helix-turn-helix-transcriptional-regulator
MRAHIESPADIGHVVRRIRESQGWSQRKLAAALGVGQRYLHELEVGRAKRIDDHYFEVLSTLGINLVAEFDDALVRRVASASSSSSAE
>NC_015125.1|WP_013584873.1|1902711_1903344_-|hypothetical-protein
MTTSPPTEAGSPESQPIALARVRRRRLRWRRVRRLSVALAVVIVAIVVAGLPLYVFPSQGDPTDANLVYVIGPPQQQRIDLGETLRDADGNLPMLISVSGSAKGHGERAFDASEIDACGEPGVTCKRPEPFTTAGEAKLLSDYVASHPSDKTVVITFTPHVARTRYIFQKCYAGDVTVMGVDTNMSLYDWAFEYAYQTAAFVKAWFTPCP
>NC_015125.1|WP_013584872.1|1900452_1902660_+|AAA-family-ATPase
MNATQQPGQEDARSALEQFGINLTDRARQGKLDPVIGRDGEIRRVSQVLTRRTKNNPVLIGEPGVGKTAVVEGLAQRIVAGDVAESLKNKELVSLDISALVAGAMYRGQFEERLKSVLKEITESDGRIITFIDELHVLMGAGGGEGSVAASNMLKPMLARGELRLIGATTLDEYREFIEKDAALERRFQQVYVGEPTVEDTVAILRGLKERYEAHHKVAIADAALVAAASLSNRYIPSRQLPDKAIDLIDEAASRLRMEIDSAPLEIDELRRHVDRLKLEELALKKEKDDASKERLATLRETLAAEQAKLDELQARWERERASLNRVGELKTRLDAARVDAERAQREGNLERASRLLYAEIPALERELMKAEREEPAGDRMVNEQVTDEDIAAVIAAWTGIPVGRLLQGETEKLLHLERELGKRLIGQKDAVKAVSDAVRRSRAGISDPNRPVGSFLFLGPTGVGKTELAKSLADFLFDDEHAMVRIDMSEYGEKHSVSRLVGAPPGYVGYEAGGQLTEAVRRRPYSVVLLDEVEKAHPEVFDVLLQVMDDGRLTDGQGRTVDFTNVILILTSNLGSPILIDPTLSMDAKREQVQALVRQAFKPEFINRLDDIVIFQALSQDDLAQIVELAVDALHKRLRERRLTLAVTPDARSWLAERGYDPVYGARPLRRLIQSEIQDRLAMAILAGTVRDGDVVRVDVASDGDSLMLVSTGPAAEESGDDSGDDVIEAEIVE
>NC_015125.1|WP_013584871.1|1899039_1900029_+|helix-turn-helix-domain-containing-protein
MRSVAVVIQPGFAPFEFGLACEAFGLDRTDEGIPNFDFRIVAPDPGVVPSNIGFSVNVELGLDAAADADIVILAPIPREQWGAVDARVIEVVRAAHARGAWLLSVCSGSFVIAASGVLDGQRATTHWRYADVMARMYPSIEVDPDVLYVQSGRIITSAGTAAGLDACLHLLRQELGAELTNRIARRMVVAPQRDGGQAQFIASPLPAAPSMSLAPVTEWMLQNLDAELSVDQLAARAHMSPRTFARRFKADLGATPAAWLARQRLLHAQRLLEETDLGLDRIAAECGFGSAAVLRQNFARTLGLTPTAYRARFSCADEVSAAPREAVPA
>NC_015125.1|WP_148272955.1|1897835_1898786_+|glycosyltransferase-family-4-protein
MLNAWARRALRGAETRRTAASSQSVGGNLRDSRDSASSASAGPVGPAPAAPDAPVAPAGTATPAEPAAARGTGPADGWAYLRRFARLSRAITAPSGHFARRLEDHSVAPETAGVDVIWNGIDDDILDAALAAGVEARRPGKPRFVWLGRMSPEKRLLPFLEAVAASGIDAEVEVIGGGAQLRAAQKLVAERRSVASVVFSGRLSYAETLARLAASDAVVQTSIGFETQGMTVFEAASLGTPAVVSDPDIASELGAGVWAVPDATTSALADTLRRAADDIASGSPVAVDPSLAERFRQSSRTAAMIAVYQRAVSAGR
>NC_015125.1|WP_013584869.1|1896190_1897414_+|glycosyltransferase
MTTPATPSDSTPSDSVPTERPLTVLIGADTFLPHVNGAARFAERLAAGLVARGHNVHVAAPSVGHSHSGTFTEVIEGEAMTMHRLPAYRFLPHDWLTFVLPWRAKHYARKVLDQVKPDVVHIQSHIVIGRGLTREARKRGIPVVATNHVMAENILDFTTLPDFLDRIFVKLAWADAARTFAMTRAVTTPTRRAADFLESTIGIRGVIPISCGIDRSNYTPDLEPRDANRILFVGRLTTEKGIDVVLRALAMLDPALDVSFDIVGGGDQRRTLEQLAEQLGLSSRVTFHGHTSEEELRALYTRASVFAIASIAELQSIATMEAMASGLPVVAADAVALPHLVHDGENGYLFEPGNAEELAARLTDVLTADPEERRRMQQASLDGVIVHDIGRTLDTFEALYRGQPIPE
>NC_015125.1|WP_013584879.1|1909436_1910123_+|hypothetical-protein
MDDDVELRRLREQVYGVDGAEATPAMIARLAELEESARTETTEGDPPPETPDAEPPAPVVEVTEPAARRPALRATLIGIGALALVGLGVALGSSLSAPPSTAATTATPDPAEESLPELTFPQTVEDVISAEILSDSGIDPSSTRYIATVSDFRIYLARPDDGDGRCIATFTSTDNRPWSAGCASGAQIGAAVFGVDKTLTVAIGEPVSSGVDGIPIRLSDSVTAFVAR
>NC_015125.1|WP_013584880.1|1910138_1910519_+|VOC-family-protein
MFDPAGAFSGFAVDDLDAAHRFYAEALGLTVEVFADTGFLSLQLGSGGSVLVYGKPHHEPASFTVLNFPVADVEAAVDDLRSRGVETKIYDDADFPTDSRGIMREGGPLIAWFRDPAGNVLAVLEE
>NC_015125.1|WP_013584881.1|1910526_1911684_-|hypothetical-protein
MLRLLAFAALGAAIGGLVVSLLGNPDPGMLIFGIAIGVCIAATTITRLAGGLAASLPSPAAVQDARDARRLGRARVDSVRQTGTFINEQPVCDIDVTVIALTGEAWATTIRKLVPLTELAAYQAGLERDVAILIEGGPEIAFADGELSPAEIDRLVVPPRSEVEVRPIPPGTRIEKGRRRGPLIGIGRRGRPLRLALFALVAVLAGAVVVLPFREAAGLTLDAWSDGRLSVDMRHPDALATAERALQEAIGHDRVVSITVIPDAVIVDAPIRVGAVETDEWAYRGGVVSHDGAAHSQPELPEEQFSWSDVALDRLWPAMEEASAQSGLPTDGATALIERATDDDVQSPTFIRNVGVPEMSFGLRDDYRDAFFRLDANGTNLRATG
>NC_015125.1|WP_013584882.1|1911986_1913111_-|ABC-transporter-permease
MSTAQRNQTAHRAPSDLQSIWLVAEREIGSKLRSKAFVISTVILVLAALASVVWGGFAANNLSGSGTPVAVTAQTQQAVSGLDGLEVTVADSDDAAKALVEDGTVDAALVSGSSDAAFDYTVVVKDNVPSTLLQMLSETPPVQELEPGAGAASALRYFIALAFGLVFLIAASTFGGTIAQSVVEEKQTRVVEILISAIPVRALLAGKVLGNTVLAMAQIVLLAAVAVIGLAVTDQAGVLSALGAPIAWFAIFFLFGFVLLASLFAAAAAMVSRQEDIGATTTPITMLIMAPYFLVIFFNDNPVVLTIMSYVPFSAPVGMPLRMYLGDAQWWEPVLSLLVLIASCVVAIGIGSRIYRNSLLRMGARVKLAEALKG
>NC_015125.1|WP_013584883.1|1913107_1913992_-|ATP-binding-cassette-domain-containing-protein
MLDLNGITKSYGGRRVLDDVSFTVAPGRLTGFVGGNGAGKTTTMRIALGVLAKDAGSVELNGSPVTTGDRRRFGYMPEERGLYPKMKVAEHIAYLARLHGFGKAEATAKATALLERLGLGERLGDLVETLSLGNQQRAQIAASLVHEPDVLILDEPFSGLDPLAVDVVAGVLQEKAASGAAVLFSSHQLDVVERLCDDLVIIAGGTIRAAGTRDALRAEHATHRYELVSRGDAGWLRDEPGVTVLDFDGGYALFDADDDASAQRVLRGAVSRGDVVSFAPQRPTLAEIFKEVIQ
>NC_015125.1|WP_013584884.1|1914266_1914935_-|response-regulator-transcription-factor
MSELRVLLVDDHAMMRAGFRTILSLEDDITVVGEAATGREAISAAAELRPDVICMDVQMPDMDGLEATRLLTADPDSDAAILIVTTFDRDDYLFAALSAGASGFLLKNAGPEELVSAVRIVGAGDALLAPEVTRRVIARFASGGAPEPAASVRPPLSLAEPLTERESEVLKLVAEALSNAEIAARLFIGEATVKTHVSNVLQKLGARDRVQAVVLAHRHGLA
>NC_015125.1|WP_043361248.1|1914927_1916187_-|sensor-histidine-kinase
MPRLTRAQQRNDIVLAVVLFLGGGLSAVLSSISGIYGDQQGSLAVALGYVAVLAIPLAFRRRWPSVAAVIVTFAYFLAVTFRIPELYAGNIAMFIALYTVGAWETNRRRATIVRIALIVGMFAWLFVVMFQQATLPVGEEVEGAFSRAGSFSPFVAYQLLTIGVNALFFGGAYYFGDRSYQQMRERAALEERTAELESEREVTAAQAVALDRVRIARELHDVVAHHVSLMGVQAGVARAVLTKDPEKAREVLSGIEGSARTSLHELRQLLETLRAPGSDSGPDTAPTTHGLTSIAALVDEASAAGLPTTFTVIGEPAQDPPPLVQVNLYRIAQEALTNARRHAGPHATADVRLRFDTDAIELEVANTGRSGSTTPGLGQLGMRERAAVSGGTIEIGPRSRGGYLVRVRVPATESEVAHV
>NC_015125.1|WP_013584886.1|1916330_1916903_+|NAD(P)H-dependent-oxidoreductase
MTDYTIGYIVGSISSTSINRRLAKALEKVAPEGVTLKEIPIKDLPFYSPDYDGNFPEVAKDFKKAIEDADGVFVVTPEYSRSIPGVLKNALDWSARPYGEASFNDKPTAVIGTSQGGIATAAGQQHLRAVLLHYNALVLGQPEGYIQSTPGLFEEDGTVTDEGTAAFLRSIIEALVTLIQRTAPAEVPAV
>NC_015125.1|WP_013584887.1|1917088_1918333_-|RNA-polymerase-sigma-factor
MTSSDHDIARRVAAIWRIEGARIVATLARVVGDLPTAEDLAQDAVAEALVQWPRDGVPNNPGAWLTAVAKRRAIDGWRRQRNLDEKYRLMGADLDEITDAEWQPIDDDVLRLVFTACHPVLAREAQVAMTLKVVGGLETDAIARLFLVPVPTMQQRIVRAKKALSAARVPFTVPDPSEWPARVGAVLSVVYLVFTEGYAASAGGAVLRTELAHEAVRLGRVLNRLLPREPEALGLSALMELQASRFAARVDANGDAVLLADQDRRRWDRSAIARGAALLERADALGRGRGPYQLQAAIALCHAQAASVDATDWDRIVLLYEMLGRIAPSPVVELNRAVAVSMASGPLGALAIVDGLAASGALKGSHLIPSVRGELLSRLGRTREARAELLEAADRSRNEREAALLRRKAEALRR
>NC_015125.1|WP_013584888.1|1918379_1918808_-|hypothetical-protein
MTKYMLIMRGTDEAYAAYKKIPFEQVINEMGAYNESMVNAGVLVAGDGLAEDMSQNFVVEFGGEEPVVTDGPYGETHELFNGFWIIEVSTKEEAVEWARRAPLIAGNKLEVRRVTDETDFAAFADNEYIQKEEGWREEQASR

Crispr_ID: NC_015125_8

• CRISPR_ID: NC_015125_8
• CRISPR_location: 1917005-1917080
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_8

Consensus_repeat	Method
GTCGAAGGGACCGGGACCAGCCG	CRISPRCasFinder

spacers of NC_015125_8

>8.1|1917028|30|NC_015125|CRISPRCasFinder
TGATCACGCCATCCCGAGGTACCTGAGCCA

CRISPR arrays and Neighbor proteins around NC_015125_8

CRISPR arrays

The CRISPR arrays of NC_015125_8

>merge|NC_015125|8|1917005-1917080|CRISPRCasFinder
GTCGAAGGGACCGGGACCAGCCGTGATCACGCCATCCCGAGGTACCTGAGCCAGTCGAAGGGACCGGGACCAGCCG

>NC_015125|8|7|1917005-1917080|CRISPRCasFinder
GTCGAAGGGACCGGGACCAGCCG	TGATCACGCCATCCCGAGGTACCTGAGCCA
GTCGAAGGGACCGGGACCAGCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013584893.1|1921363_1922194_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|319832
NC_015125.1|WP_013584886.1|1916330_1916903_+|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223508
NC_015125.1|WP_013584897.1|1926074_1926503_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013584882.1|1911986_1913111_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224582
NC_015125.1|WP_013584895.1|1922649_1923597_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235737
NC_015125.1|WP_013584888.1|1918379_1918808_-|hypothetical-protein	unknown	unknown	gnl|CDD|226318
NC_015125.1|WP_013584887.1|1917088_1918333_-|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|227277
NC_015125.1|WP_043361248.1|1914927_1916187_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NC_015125.1|WP_013584890.1|1919249_1920095_-|exodeoxyribonuclease-III	unknown	unknown	gnl|CDD|197320
NC_015125.1|WP_013584883.1|1913107_1913992_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|226631
NC_015125.1|WP_013584881.1|1910526_1911684_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013584891.1|1920418_1920997_+|orotate-phosphoribosyltransferase	unknown	unknown	gnl|CDD|234771
NC_015125.1|WP_013584896.1|1923639_1926123_+|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl|CDD|319795
NC_015125.1|WP_013584884.1|1914266_1914935_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NC_015125.1|WP_043361244.1|1905999_1907361_-|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|237233
NC_015125.1|WP_013584878.1|1907463_1909236_+|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl|CDD|225922
NC_015125.1|WP_013584894.1|1922286_1922457_-|CsbD-family-protein	unknown	unknown	gnl|CDD|283241
NC_015125.1|WP_013584892.1|1921188_1921341_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013584879.1|1909436_1910123_+|hypothetical-protein	unknown	unknown	gnl|CDD|236507
NC_015125.1|WP_013584880.1|1910138_1910519_+|VOC-family-protein	unknown	unknown	gnl|CDD|319925

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013584893.1|1921363_1922194_-|HAD-family-hydrolase	gnl|CDD|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.2353e-121
NC_015125.1|WP_013584886.1|1916330_1916903_+|NAD(P)H-dependent-oxidoreductase	gnl|CDD|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	2.96557e-40
NC_015125.1|WP_013584882.1|1911986_1913111_-|ABC-transporter-permease	gnl|CDD|224582	COG1668, NatB, ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism].	1.05625e-20
NC_015125.1|WP_013584895.1|1922649_1923597_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	4.23525e-56
NC_015125.1|WP_013584888.1|1918379_1918808_-|hypothetical-protein	gnl|CDD|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	2.40331e-28
NC_015125.1|WP_013584887.1|1917088_1918333_-|RNA-polymerase-sigma-factor	gnl|CDD|227277	COG4941, COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription].	1.23096e-138
NC_015125.1|WP_043361248.1|1914927_1916187_-|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.394e-39
NC_015125.1|WP_013584890.1|1919249_1920095_-|exodeoxyribonuclease-III	gnl|CDD|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	1.42906e-116
NC_015125.1|WP_013584883.1|1913107_1913992_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|226631	COG4152, COG4152, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	1.75538e-95
NC_015125.1|WP_013584891.1|1920418_1920997_+|orotate-phosphoribosyltransferase	gnl|CDD|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	4.26308e-64
NC_015125.1|WP_013584896.1|1923639_1926123_+|HAD-IC-family-P-type-ATPase	gnl|CDD|319795	cd02609, P-type_ATPase, uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7. This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.	0
NC_015125.1|WP_013584884.1|1914266_1914935_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.51048e-74
NC_015125.1|WP_043361244.1|1905999_1907361_-|glucose-6-phosphate-dehydrogenase	gnl|CDD|237233	PRK12853, PRK12853, glucose-6-phosphate dehydrogenase.	0
NC_015125.1|WP_013584878.1|1907463_1909236_+|glycoside-hydrolase-family-15-protein	gnl|CDD|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	1.10501e-121
NC_015125.1|WP_013584894.1|1922286_1922457_-|CsbD-family-protein	gnl|CDD|283241	pfam05532, CsbD, CsbD-like. CsbD is a bacterial general stress response protein. It's expression is mediated by sigma-B, an alternative sigma factor. The role of CsbD in stress response is unclear.	1.37164e-07
NC_015125.1|WP_013584879.1|1909436_1910123_+|hypothetical-protein	gnl|CDD|236507	PRK09424, pntA, Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha.	0.00721564
NC_015125.1|WP_013584880.1|1910138_1910519_+|VOC-family-protein	gnl|CDD|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.60139e-08

Protein sequences

>NC_015125.1|WP_013584886.1|1916330_1916903_+|NAD(P)H-dependent-oxidoreductase
MTDYTIGYIVGSISSTSINRRLAKALEKVAPEGVTLKEIPIKDLPFYSPDYDGNFPEVAKDFKKAIEDADGVFVVTPEYSRSIPGVLKNALDWSARPYGEASFNDKPTAVIGTSQGGIATAAGQQHLRAVLLHYNALVLGQPEGYIQSTPGLFEEDGTVTDEGTAAFLRSIIEALVTLIQRTAPAEVPAV
>NC_015125.1|WP_043361248.1|1914927_1916187_-|sensor-histidine-kinase
MPRLTRAQQRNDIVLAVVLFLGGGLSAVLSSISGIYGDQQGSLAVALGYVAVLAIPLAFRRRWPSVAAVIVTFAYFLAVTFRIPELYAGNIAMFIALYTVGAWETNRRRATIVRIALIVGMFAWLFVVMFQQATLPVGEEVEGAFSRAGSFSPFVAYQLLTIGVNALFFGGAYYFGDRSYQQMRERAALEERTAELESEREVTAAQAVALDRVRIARELHDVVAHHVSLMGVQAGVARAVLTKDPEKAREVLSGIEGSARTSLHELRQLLETLRAPGSDSGPDTAPTTHGLTSIAALVDEASAAGLPTTFTVIGEPAQDPPPLVQVNLYRIAQEALTNARRHAGPHATADVRLRFDTDAIELEVANTGRSGSTTPGLGQLGMRERAAVSGGTIEIGPRSRGGYLVRVRVPATESEVAHV
>NC_015125.1|WP_013584884.1|1914266_1914935_-|response-regulator-transcription-factor
MSELRVLLVDDHAMMRAGFRTILSLEDDITVVGEAATGREAISAAAELRPDVICMDVQMPDMDGLEATRLLTADPDSDAAILIVTTFDRDDYLFAALSAGASGFLLKNAGPEELVSAVRIVGAGDALLAPEVTRRVIARFASGGAPEPAASVRPPLSLAEPLTERESEVLKLVAEALSNAEIAARLFIGEATVKTHVSNVLQKLGARDRVQAVVLAHRHGLA
>NC_015125.1|WP_013584883.1|1913107_1913992_-|ATP-binding-cassette-domain-containing-protein
MLDLNGITKSYGGRRVLDDVSFTVAPGRLTGFVGGNGAGKTTTMRIALGVLAKDAGSVELNGSPVTTGDRRRFGYMPEERGLYPKMKVAEHIAYLARLHGFGKAEATAKATALLERLGLGERLGDLVETLSLGNQQRAQIAASLVHEPDVLILDEPFSGLDPLAVDVVAGVLQEKAASGAAVLFSSHQLDVVERLCDDLVIIAGGTIRAAGTRDALRAEHATHRYELVSRGDAGWLRDEPGVTVLDFDGGYALFDADDDASAQRVLRGAVSRGDVVSFAPQRPTLAEIFKEVIQ
>NC_015125.1|WP_013584882.1|1911986_1913111_-|ABC-transporter-permease
MSTAQRNQTAHRAPSDLQSIWLVAEREIGSKLRSKAFVISTVILVLAALASVVWGGFAANNLSGSGTPVAVTAQTQQAVSGLDGLEVTVADSDDAAKALVEDGTVDAALVSGSSDAAFDYTVVVKDNVPSTLLQMLSETPPVQELEPGAGAASALRYFIALAFGLVFLIAASTFGGTIAQSVVEEKQTRVVEILISAIPVRALLAGKVLGNTVLAMAQIVLLAAVAVIGLAVTDQAGVLSALGAPIAWFAIFFLFGFVLLASLFAAAAAMVSRQEDIGATTTPITMLIMAPYFLVIFFNDNPVVLTIMSYVPFSAPVGMPLRMYLGDAQWWEPVLSLLVLIASCVVAIGIGSRIYRNSLLRMGARVKLAEALKG
>NC_015125.1|WP_013584881.1|1910526_1911684_-|hypothetical-protein
MLRLLAFAALGAAIGGLVVSLLGNPDPGMLIFGIAIGVCIAATTITRLAGGLAASLPSPAAVQDARDARRLGRARVDSVRQTGTFINEQPVCDIDVTVIALTGEAWATTIRKLVPLTELAAYQAGLERDVAILIEGGPEIAFADGELSPAEIDRLVVPPRSEVEVRPIPPGTRIEKGRRRGPLIGIGRRGRPLRLALFALVAVLAGAVVVLPFREAAGLTLDAWSDGRLSVDMRHPDALATAERALQEAIGHDRVVSITVIPDAVIVDAPIRVGAVETDEWAYRGGVVSHDGAAHSQPELPEEQFSWSDVALDRLWPAMEEASAQSGLPTDGATALIERATDDDVQSPTFIRNVGVPEMSFGLRDDYRDAFFRLDANGTNLRATG
>NC_015125.1|WP_013584880.1|1910138_1910519_+|VOC-family-protein
MFDPAGAFSGFAVDDLDAAHRFYAEALGLTVEVFADTGFLSLQLGSGGSVLVYGKPHHEPASFTVLNFPVADVEAAVDDLRSRGVETKIYDDADFPTDSRGIMREGGPLIAWFRDPAGNVLAVLEE
>NC_015125.1|WP_013584879.1|1909436_1910123_+|hypothetical-protein
MDDDVELRRLREQVYGVDGAEATPAMIARLAELEESARTETTEGDPPPETPDAEPPAPVVEVTEPAARRPALRATLIGIGALALVGLGVALGSSLSAPPSTAATTATPDPAEESLPELTFPQTVEDVISAEILSDSGIDPSSTRYIATVSDFRIYLARPDDGDGRCIATFTSTDNRPWSAGCASGAQIGAAVFGVDKTLTVAIGEPVSSGVDGIPIRLSDSVTAFVAR
>NC_015125.1|WP_013584878.1|1907463_1909236_+|glycoside-hydrolase-family-15-protein
MTTPIEDYAVLSNCRSAALVSRDGSIDWLCLPRYDSGSMLGALLGDGSHGRWSLRPADPAARATRRYDGDTFVLVTRWETETGVADVYDAMPVDEGVEAVIRRVVGVSGEVDFVSEVRLRFDYARAVPWVQQIGQGGEHAILAVAGPDAVVVRGPRLIAVDTAHRGRWTTAAGQSVDSVLSWGASWQEPPAPFNVEAALERTREWWAAWADRVQSAGTHAALVTRSLMVLRALTHSETGGIVAAATTSLPEAFGGSRNWDYRYVWLRDAALTLSAYIDHGYLDAAQHWRTWLLRAIAGDPADVQIMYGIAGERDLPEREIPSLPGYGGAAPVRIGNGAVTQYQADVIGEVMVALEAARNAGVEETTFSWSLQRALLNQLAGEVDKPDLGIWEMRGEPHFFTHSRAMVWAAFDRGIRAVEEGGHDGEVDTWRTLRDKVRADIDARGVHDGGWFTQHFDTDEVDASLLVLPQVGFCAYDDPRMLATVARMEETLMPDGWLLRYRTTGVDGLSGDEHPFLACSFWLVGQYAHSGRRDEAVALMKRLTAVANDLGLLSEEYDPTTGRQAGNTPQALSHLALVGAADALDATAAG
>NC_015125.1|WP_043361244.1|1905999_1907361_-|glucose-6-phosphate-dehydrogenase
MAADTTLIILGASGDLTSRLLLPALGQLLAREPGRSVRLHGAGMDDWTDEHWREVVHQAFQTMDADAAFDQVSATTYSQADITKAADLLTLLDAAEGRPALYFAVPPAVTEKSCIALADVNIPEGTILALEKPFGTDEASAHKLNQQLATLVPESQVFRIDHFLGRSTVLNLLGVRFANRLIESVWSADDIATITVDFPEKLGLEGRAGYYDSAGALVDMIQSHLLQVMAFVTMEPPSSLDQLDLRDATAAVLRATHVLDDDPVANSRRARYTAGDVGDRHFVSYVDEPGVDPSRDTETLAEMTVEVRTTRWQGVPITLRSGKALDAGDPAVTVTFKPVRHLPTGFVGESEPSKLVFSLGPDTMSLELNVNGADDPLELERVALAADLGEGALKAYGEVLSGILDGDAMLAVRGDAAEQCWRIVQPVIDAWRQNKVPLDEYPAGSTGPASWQG
>NC_015125.1|WP_013584887.1|1917088_1918333_-|RNA-polymerase-sigma-factor
MTSSDHDIARRVAAIWRIEGARIVATLARVVGDLPTAEDLAQDAVAEALVQWPRDGVPNNPGAWLTAVAKRRAIDGWRRQRNLDEKYRLMGADLDEITDAEWQPIDDDVLRLVFTACHPVLAREAQVAMTLKVVGGLETDAIARLFLVPVPTMQQRIVRAKKALSAARVPFTVPDPSEWPARVGAVLSVVYLVFTEGYAASAGGAVLRTELAHEAVRLGRVLNRLLPREPEALGLSALMELQASRFAARVDANGDAVLLADQDRRRWDRSAIARGAALLERADALGRGRGPYQLQAAIALCHAQAASVDATDWDRIVLLYEMLGRIAPSPVVELNRAVAVSMASGPLGALAIVDGLAASGALKGSHLIPSVRGELLSRLGRTREARAELLEAADRSRNEREAALLRRKAEALRR
>NC_015125.1|WP_013584888.1|1918379_1918808_-|hypothetical-protein
MTKYMLIMRGTDEAYAAYKKIPFEQVINEMGAYNESMVNAGVLVAGDGLAEDMSQNFVVEFGGEEPVVTDGPYGETHELFNGFWIIEVSTKEEAVEWARRAPLIAGNKLEVRRVTDETDFAAFADNEYIQKEEGWREEQASR
>NC_015125.1|WP_013584890.1|1919249_1920095_-|exodeoxyribonuclease-III
MRLATWNVNSIRARVTRTVEFCVREHIDVLAMQEIKCKTEQFPYAAFEEAGYHVAAHGLNQWNGVAIASREPLEDVEIGFPDMPGFEKGKEGPDLPQEARAIGATVNGVRVWSLYVPNGRGLDDPHYAYKLDWLEKLRQYTADTLAKDPDLPLALTGDFNIAPTDADNGDPTVVEGATTHVSPAERAAFAAFETAGLTDVVRPLIPTGYTYWDYKQLRFPRNEGLRIDFILGSRAFADAVQGAEIHRDERKGEVPSDHVPVVADLDPTDAGDDDDLPMIFG
>NC_015125.1|WP_013584891.1|1920418_1920997_+|orotate-phosphoribosyltransferase
MTAASTPELEADRQALICLINAEAVFHGDFTLSSGKKATYYVDMRKLTLDHRAAPAIGRLVLDLVKDLDGVVAVGGLTLGADPIANAVMHESVHAGRPLDAFVVRKEPKDHGRGRQIEGADVKGKRVVVVEDTSTTGQSALKAVEALRREGAEVIAVAVIVDRKTGAQAAIEAEGLQWLASIDLDDLGLQPQ
>NC_015125.1|WP_013584892.1|1921188_1921341_-|hypothetical-protein
MDDRTLWLISALIITAGSLVALIVQWRRSRRGGGRRDPFDGPGPGDDERR
>NC_015125.1|WP_013584893.1|1921363_1922194_-|HAD-family-hydrolase
MRTRAEIECWLTDMDGVLVHENTPVPGAAELLAQWRAEGTPFLVLTNNSIFTPRDLSARLRASGLVVPESSIWTSALATADFLKSQMPGGSAFVIGEAGLTTALHEAGFIMTETAPDYVVVGETRNYSFEAITKAIRFIRGGSRFIATNPDATGPSTEGVLPATGAIAALITKATGREPYIVGKPNPMMFRSALNRIGAHSENTGMIGDRMDTDIVAGIEAGLHTVLVMTGISDEREIERYPFRPDEILGSVAELVRDEPLESDFADGEDGLAEGL
>NC_015125.1|WP_013584894.1|1922286_1922457_-|CsbD-family-protein
MGLDDKIKNAAQDIVGKAKEAIGNATDNDRLAAEGKLEQTEAHAKKAGENVKDAFK
>NC_015125.1|WP_013584895.1|1922649_1923597_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTRAEWDPRNLPDLSGRTYLVTGATRGLGFFACEQLAAARAHVLLTGRSPHKLQTAKEALKRSNPDASIETLLLDTSNLGSVRAAAATARARGRLDGLLLNAGIVHPPKNRETAGGHELVFATNVLGHFALAGEMLKPLAAARGRMVWVGSMSTSLWNHVPTDPELVEGYSPWRAYVQSKAATTALGLEADRRLRAHSVPVESLVAHPGYSTSGRTRGIRGVNEPTRLSRFVDNLQAPVTQSKEQGAWSLVRALVDPTAEGGTMYGPALVARGLPRPATPSRRARATDLGSDLWLACETATHVRWPFDRVRRAAS
>NC_015125.1|WP_013584896.1|1923639_1926123_+|HAD-IC-family-P-type-ATPase
MDQAIADSTDADDARGLTAAAVAERVASGQTNSYAADTSRSAWNIVRANVFTLFNGIVAACFLVLLLLGRWQDALFGIAALSNAVIGCVQEFRAKAALDRLALLNAPRARVRRDGVDAEIAPGEVVRDDLLVLRAGDQVPADATVVESRGLQIDESMLTGESDAVDKRPGDEALSGSIVVGGEGTARATRVGAESYANTFASEAKKFQLVSSELRTSIDRVLTWVGWGIGPVGLLVLNAQMMVAGGWAEAFQQGTWSQAVVNTIASLTAMIPLGLVLMTSIAFAVGAARLAGKKVLVNELPAVEGLARVDVICLDKTGTLTAGEIRFDDALALTDRPGWRETLGWYGAADDANATARCLRDPFPVDAPLVPVQRIPFSSARKWSAVSFAERAEGTWILGAPEMVFGDQAADPATALGAAVTRLASSGRRTLVLAHTATALDDDDVAAERFRDDPVPVAVLTFIEAVRPDAAGALAFFREQGVGVRVISGDNPRTVAAIAREVGLEVEEGYDARRLPEDDVELGRIMEEHTVFGRVTPDQKKRIVTALQARGHVVAMTGDGVNDALAIKTADIGIAMNSGAAATKAVARLVLLDGRFSHLPSVVAEGRQVIANIERVSMLFLTKTVYATGLAVLFGVLVMEFPFLPRQLSITDGLTIGIPAFFLALLPNTQRYVPGFLKRSLSFAIPAGVVIAVSLTVYTRLAMDLGLSVEQLRTGATIILAIVAIWVLTVLSRPITRVKVLVVGAMFIALTAIFTIPVLGEFFQLKDPGEDGAWLVTAVVIVALAAIEAVRFAHRRFVRRLLAQRAARAETPQMTGVAGASTGGRVK
>NC_015125.1|WP_013584897.1|1926074_1926503_-|hypothetical-protein
MTTPAKVRRPVAVTVAIMLVYIGGLLNTALGVLVLLSRYEVSADLVLPVSLVGAATILLGLLTIAGGSALSRGSRLARILLTAYLSVLVVLQAAAMALTELDATLAAALVAALAVIAALWIPGNARRYFTRPPVEAPATPVI

Crispr_ID: NC_015125_9

• CRISPR_ID: NC_015125_9
• CRISPR_location: 2067029-2067138
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_9

Consensus_repeat	Method
GGTGGCTGAGCTCGTCGAAGCCTCCG	CRISPRCasFinder

spacers of NC_015125_9

>9.1|2067055|58|NC_015125|CRISPRCasFinder
CGGGCCTCGCGGTCGTGGGCGGTCCCTTCGGCGGGCTCAGGGACCTGGGTTGCGCGGT

CRISPR arrays and Neighbor proteins around NC_015125_9

CRISPR arrays

The CRISPR arrays of NC_015125_9

>merge|NC_015125|9|2067029-2067138|CRISPRCasFinder
GGTGGCTGAGCTCGTCGAAGCCTCCGCGGGCCTCGCGGTCGTGGGCGGTCCCTTCGGCGGGCTCAGGGACCTGGGTTGCGCGGTGGTGGCTGAGCTCGTCGAAGCCTCCG

>NC_015125|9|8|2067029-2067138|CRISPRCasFinder
GGTGGCTGAGCTCGTCGAAGCCTCCG	CGGGCCTCGCGGTCGTGGGCGGTCCCTTCGGCGGGCTCAGGGACCTGGGTTGCGCGGT
GGTGGCTGAGCTCGTCGAAGCCTCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_148272960.1|2076126_2076876_-|coenzyme-F420-0:L-glutamate-ligase	unknown	unknown	gnl|CDD|183957
NC_015125.1|WP_013585034.1|2075365_2075974_+|cobalt-ABC-transporter-permease	unknown	unknown	gnl|CDD|223692
NC_015125.1|WP_013585017.1|2055595_2055910_-|YbjQ-family-protein	unknown	unknown	gnl|CDD|376657
NC_015125.1|WP_013585022.1|2063320_2064040_+|VIT-family-protein	unknown	unknown	gnl|CDD|153123
NC_015125.1|WP_013585036.1|2076880_2077387_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_015125.1|WP_043361281.1|2066393_2066921_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NC_015125.1|WP_013585029.1|2071302_2071857_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|172294
NC_015125.1|WP_013585016.1|2054987_2055572_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_015125.1|WP_013585021.1|2059687_2063152_-|choice-of-anchor-I-family-protein	unknown	unknown	gnl|CDD|223808
NC_015125.1|WP_013585033.1|2074685_2075372_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213192
NC_015125.1|WP_013585032.1|2073582_2074689_+|thiolase-family-protein	unknown	unknown	gnl|CDD|238383
NC_015125.1|WP_013585023.1|2064336_2065506_+|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|173851
NC_015125.1|WP_013585024.1|2065585_2066374_+|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|180295
NC_015125.1|WP_013585018.1|2056050_2057595_+|MmgE/PrpD-family-protein	unknown	unknown	gnl|CDD|377179
NC_015125.1|WP_013585019.1|2057594_2058773_+|thiolase-family-protein	unknown	unknown	gnl|CDD|238383
NC_015125.1|WP_013585030.1|2071926_2072523_+|biotin-transporter-BioY	unknown	unknown	gnl|CDD|224187
NC_015125.1|WP_013585020.1|2058913_2059624_+|Type-1-glutamine-amidotransferase-like-domain-containing-protein	unknown	unknown	gnl|CDD|153223
NC_015125.1|WP_013585031.1|2072519_2073599_+|acyl--CoA-ligase	unknown	unknown	gnl|CDD|223395
NC_015125.1|WP_013585028.1|2068913_2070956_+|cytochrome-b/b6-domain-containing-protein	unknown	unknown	gnl|CDD|236090
NC_015125.1|WP_013585027.1|2067959_2068913_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl|CDD|224936

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_148272960.1|2076126_2076876_-|coenzyme-F420-0:L-glutamate-ligase	gnl|CDD|183957	PRK13294, PRK13294, F420-0--gamma-glutamyl ligase; Provisional.	7.78738e-85
NC_015125.1|WP_013585034.1|2075365_2075974_+|cobalt-ABC-transporter-permease	gnl|CDD|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	1.40972e-12
NC_015125.1|WP_013585017.1|2055595_2055910_-|YbjQ-family-protein	gnl|CDD|376657	pfam01906, YbjQ_1, Putative heavy-metal-binding. From comparative structural analysis, this family is likely to be a heavy-metal binding domain. The domain oligomerizes as a pentamer. The domain is about 100 amino acids long and is found in prokaryotes.	3.1066e-46
NC_015125.1|WP_013585022.1|2063320_2064040_+|VIT-family-protein	gnl|CDD|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	7.31801e-93
NC_015125.1|WP_013585036.1|2076880_2077387_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.78371e-13
NC_015125.1|WP_043361281.1|2066393_2066921_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.93804e-19
NC_015125.1|WP_013585029.1|2071302_2071857_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl|CDD|172294	PRK13756, PRK13756, TetR family transcriptional regulator.	5.29709e-12
NC_015125.1|WP_013585016.1|2054987_2055572_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.70245e-11
NC_015125.1|WP_013585021.1|2059687_2063152_-|choice-of-anchor-I-family-protein	gnl|CDD|223808	COG0737, UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism].	5.13603e-85
NC_015125.1|WP_013585033.1|2074685_2075372_+|ABC-transporter-ATP-binding-protein	gnl|CDD|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	3.60968e-64
NC_015125.1|WP_013585032.1|2073582_2074689_+|thiolase-family-protein	gnl|CDD|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.73239e-102
NC_015125.1|WP_013585023.1|2064336_2065506_+|acyl-CoA-dehydrogenase-family-protein	gnl|CDD|173851	cd01162, IBD, Isobutyryl-CoA dehydrogenase. Isobutyryl-CoA dehydrogenase (IBD) catalyzes the alpha, beta- dehydrogenation of short branched chain acyl-CoA intermediates in valine catabolism. It is predicted to be a homotetramer.	0
NC_015125.1|WP_013585024.1|2065585_2066374_+|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|180295	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional.	5.61445e-138
NC_015125.1|WP_013585018.1|2056050_2057595_+|MmgE/PrpD-family-protein	gnl|CDD|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	6.4083e-140
NC_015125.1|WP_013585019.1|2057594_2058773_+|thiolase-family-protein	gnl|CDD|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.09798e-179
NC_015125.1|WP_013585030.1|2071926_2072523_+|biotin-transporter-BioY	gnl|CDD|224187	COG1268, BioY, Uncharacterized conserved protein [General function prediction only].	2.30516e-37
NC_015125.1|WP_013585020.1|2058913_2059624_+|Type-1-glutamine-amidotransferase-like-domain-containing-protein	gnl|CDD|153223	cd03129, GAT1_Peptidase_E_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins. Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins. This group contains proteins similar to the aspartyl dipeptidases Salmonella typhimurium peptidase E and Xenopus laevis peptidase E and, extracellular cyanophycinases from Pseudomonas anguilliseptica BI (CphE) and Synechocystis sp. PCC 6803 CphB. In bacteria peptidase E is believed to play a role in degrading peptides generated by intracellular protein breakdown or imported into the cell as nutrient sources. Peptidase E uniquely hydrolyses only Asp-X dipeptides (where X is any amino acid), and one tripeptide Asp-Gly-Gly. Cyanophycinases are intracellular exopeptidases which hydrolyze the polymer cyanophycin (multi L-arginyl-poly-L-aspartic acid) to the dipeptide beta-Asp-Arg. Peptidase E and cyanophycinases are thought to have a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad typical of GATase1 domains by having a Ser in place of the reactive Cys at the nucleophile elbow. Xenopus peptidase E is developmentally regulated in response to thyroid hormone and, it is thought to play a role in apoptosis during tail reabsorption.	1.53902e-25
NC_015125.1|WP_013585031.1|2072519_2073599_+|acyl--CoA-ligase	gnl|CDD|223395	COG0318, CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	2.52867e-42
NC_015125.1|WP_013585028.1|2068913_2070956_+|cytochrome-b/b6-domain-containing-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	8.68565e-13
NC_015125.1|WP_013585027.1|2067959_2068913_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl|CDD|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	1.70764e-86

Protein sequences

>NC_015125.1|WP_043361281.1|2066393_2066921_-|MarR-family-transcriptional-regulator
MTRRLPVDPIAEAKRQWLAHGWDDAADGMTVVTSVIRAHQLLMASIERALKPFDLSFSRFELLRLLAFTREGRMPMASAIARLQVHPTSVTNTVERLTRDGLVTREPHPTDGRAALLALTDAGRRRVDEATAALNAVFADLGLDDDDATELVRIIARFRKGAGDFADPAPVPDPL
>NC_015125.1|WP_013585024.1|2065585_2066374_+|enoyl-CoA-hydratase/isomerase-family-protein
MTEQDAGYETIRVEQRARVGWITLDRPEALNALNTRTMHEVVAAAEAFDADEGVGAIVVTGSEKAFAAGADIKEMEGKSSVEMTLTDHFGGWSRFAAVRTPVIAAVSGYALGGGCELALMCDVILASDRAKFGQPEVQLGVIPGMGGTQRLVRALGYYKAAELVLTGRMIDAAEAERVGLVSRVVPGADLLDEAQAVAETIAEKPLPALYAAKAALDAALETSLAEGLRFERQAFAGLFDTADQKEGMAAFREKRAPSFTHR
>NC_015125.1|WP_013585023.1|2064336_2065506_+|acyl-CoA-dehydrogenase-family-protein
MDTIPAPALDAPVLSADERAAILDAVRDFAATELAPHALEWDAEKHFPRDVLRRAGELGLGGVYVRDDVGGAGLSRRDAVAIFEELAYGDPTVTAYITIHNMVAWMIDAYGTSVQRERWLPGLVAMDDLGAYCLTEPGAGSDAAAITTSAIRHGDTYVLTGVKQFISGAGEASVYVVMARTGEPGARGISAFLVPADAEGLSFGPLEKKMGWNAQPTRQVILDEVRVPAENLLGGEGRGFSIAMTALNGGRLNIATCSIGGARWALDRAIAYVHERFTFGEALAEKQSVVFAVADMATELEAARLLVREAATALDAKDPDTATRCAMAKRFATDVGFRVANEALQLHGGYGYLQDYGIEKVVRDLRVHQILEGTNEIMRLIIGRSVLAA
>NC_015125.1|WP_013585022.1|2063320_2064040_+|VIT-family-protein
MTTLPGAHPDEPHRQGLAQRLNGLRAGVLGANDGIVSTAAVVVGVAGATSEVGPVLIAGLAALVGGAVSMALGEYVSVSSQRDSERALIQKERRELAEDPDAEFSELVGLYEAQGLTRDTATRVATELTASDALKAHLAIELNIDADDVVSPWTAALASAVAFTVGALLPLLTILLAPVGIRVPLTFAAVLVALAVTGYVAAWIGGARRGRSILRTVIGGALALGATYLVGSLFGVAAG
>NC_015125.1|WP_013585021.1|2059687_2063152_-|choice-of-anchor-I-family-protein
MPSPFLRRTVALAATTAAVCALALSSVTAASAAIVVDPVRDTPADSAMSLRPIGTYETGVFDQSAAEIVHAYKNRLFVVNAQAGAVDVLDMSAPATPTKLYSIAGTGVANSLAVRADGLGVIALEAANKTAPGRLVFFDADAAEPTVLGEVTVGALPDMVTISADGTVAVVANEGEPADDFSTDPEGSIGVVALPAEKAAPTQDAVRTAGFGGFEQGGSQTLDPAVRVFGPDVAAPDQGDTPLAANRVSRNLEPEYVAIAGGTAYVALQEANAIAVVDLASAEVTGIRPLGFKDYGVETLDASDRDPEDAPTYTQKSYPGLFGMYMPDGIQAYEANGETFLVTANEGDGREWGDFTDTARVKDLGEDGLAPVCADSPLAGSLDDADLGRLNVATDMGLNADGTCYSELYTFGGRGFSVWNTAGEQVFDSGSDVERITHDANPDFFNSNHSASNLEGRSDDKGPEPENLAIGEVDGRTYAFVGLERVGGVMTYDITDPAAATYAGYVNNRDFSVSVEDQLTGDETVDRELLSRAGDLGPEGVDFIAADASPTGRPLVAVGNEVSGTTTLFEVSNPNLKNIDILTVNDFHGRLEAGSQGEAGAAVIAGAVKATEAANPNTLFVSAGDNIGASTFTSLIQEDSPTIDTLKASGLDVSAVGNHEFDRGFADLTDRVLPEYGGGEYGLGANVYKKGTKEPALDEYAVKDVDGVRVAFIGTVTPDTATMVDPAGIADLEFGDQLEAANRVADEITRGDLADVIVLLTHSGAAVSDDCAAIAADQAGFGKLAVNASPEIDAIVSAHTHQTYACDLPVAGTDRTRPVIQAYEYGKAMGRLSLTWDTRTDSLASLSGTTFPLAGAFAPDAAIEAKVAEYVAQADVIGAKPVGRISGDILRGGTPSGADRGVESSMGNGVADVYLWATSANPAYAGTKAQIALMNPGGLRADLLKGDDGVVTYKEAALVQPFANTLVTVTLTGEQLRGILNEQWKAEGDRPKLHLGVSEGFSYEYEQDAANPRVGSVVSMAYQGKTIADGDTFTVVTNSFLANGGDGFPTFAAGTDRTDTGQIDLDATLAYFEATPVVDPAPLGRAVVASGEAPGENPGEQPGTPGPDAEQPGQRPGQGLANTGTEAPWGLALAGGFLVVAGGLAFALRRRRAV
>NC_015125.1|WP_013585020.1|2058913_2059624_+|Type-1-glutamine-amidotransferase-like-domain-containing-protein
MSVHLLGGGRDVARCGGLLEPFVAEARERAGDRDPVIAVLLVLEADDDSSVARFRSVLEAAGAESIRVEAIVEGESFTNAAIEADGVFVGGGLTPAYHDAFRVIREELRERVGQGMPYAGFSAGAAIAAERALVGGWLRGGVEVCGEDAAEELGELEVRPGLGLLGFAVDVHAAQWGTLSRLVAAVDAGLVTDGVAIDENTALVVSAQAAPAVRGSGQVWRVESAASGVLVQLLRA
>NC_015125.1|WP_013585019.1|2057594_2058773_+|thiolase-family-protein
MSEPRIVLVAGARTPIGSFGGSLSSVDAYELGAVAVTEALRRAGVEKDAVDEVVMGCIAQNGPDAYNARRVALAAGLPTRVPAFTVNRLCGSGLQAIWSAAQELRWGGIDIAVAGGDESMSRTPFLEYGARGNARLGDRTLLDGTLAILTDPFSGRHMGTTAEVVASRYGVSRAEQDAFAVESQRRAALDASRAAFAEEIVPVTTGGKRPVEVSVDEHPRPGTTLEALAGLRPAFEKDGSVTAGNSSGINDGAAATVLMRENDVRDRGLSGLATLEAVTTAGVDPEIMGYAPVLALQRLWDQTGLTPADVDVIELNEAFASQAVAVIRDAALDPAKVNPYGGAIALGHPVGATGAILTVRAALDLQRRDLEYAVVTMCIGGGQALAALLRRY
>NC_015125.1|WP_013585018.1|2056050_2057595_+|MmgE/PrpD-family-protein
MTITHHVRVHRSEENLAREGQLAWSLARVAVDPVPVDADVVDMIINRVIDNAAVAAASLSRGPVSAARQQALDHAVSIGGSGATVFGCALERRSSPEWAAWANGVAVRELDYHDTFLAAEYSHPGDNIPPVLAVAQHTGRDGAAVVRALATAYEIQIDLVRAISLHKHKIDHVAHLGPAAAAGIGTLLGLDQATIYQAIGQALHTTTATRQSRKGEISTWKAHAPAFAGKMAIEAVDRAMRGETSPSPIYEGEDGVIAWLLDGPDASYDVPLPGDGEPKRGIIDSYTKEHSAEYQAQAWIDLARRLGTHRPELRDPANIASIVLHTSHHTHYVIGSGANDPQKYDPTASRETLDHSIPYIFAVALQDGAWHHVHSYAPARANRPDTVELWHKITTAEDAEWTRRYHSEDPNEKAFGGRVEITLTDGTTVTDGTTVTDEIAVADAHPLGARPFARDDYLRKFRTLAEPVLLPEEIDRFLNLAQRLPELTPAEVTQLTIVAKPGILASAPAPKGLF
>NC_015125.1|WP_013585017.1|2055595_2055910_-|YbjQ-family-protein
MLVTTMNDVPGRQITEVFGEVTGLTVRARNLGVQFGAGLKSIFGGELQGLTKQLQESRDEAKQRLIEQAQALGADAVIAMRFDTSEVAQNFQEVVAYGTAVKLA
>NC_015125.1|WP_013585016.1|2054987_2055572_+|TetR/AcrR-family-transcriptional-regulator
MGRTPSFERAAVVDAARDVFWQRGYAETGIAELEDATGLTRSSIYNAFGSKRGLFDAVLAAYLDDVVRTRLRPLGGGDPGALEAYVAEMIDGIAADTPRARLGCLLLNAGSSPLATDDAEVRTLVSDYAAEMRTAIRAAVSDRRPDLGPDAVDALAAVCASLVVAGLTLARADRDAALATLASIPTTLESWGRG
>NC_015125.1|WP_013585027.1|2067959_2068913_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MAVALVLLEVLPGGALAASSAGLLAAARRVGDPVALIAGPADAAAEAAALGAVRVLAVDVESDALTLPVVDALAAAVARESPDLVLASNSVESRDAVARLAARLRLPLAADVVGVERDDLGVVAHHAVFGGAFTVDGAPTFGTLVATLRPGAVTERLDAQPLAVERLEVVASGVPSARVEGFSETAAPSSRPELRGAKVVVAGGRGVGSRENFALVEQLADVLGAAVGASRAAVDAGYVPVSAQVGQTGVTVSPRLYIALGISGAIQHRAGMQTATTIVAVDKDPEAPIFAIADFGIVGDLFTVVPQLISALEAQKK
>NC_015125.1|WP_013585028.1|2068913_2070956_+|cytochrome-b/b6-domain-containing-protein
MASTPRTPRRGLPRVPGGEPWPPAVSGASEADDDISADGAAPGQDARGDAVAVPASQNRADLADSAGDSASSARISEPGPPSDPDAAGSTPASAVRRGLPRVRGGEPWPPATALADSEHGAGFGRGSETDPDPATPSESATAAASQNAAHLADSAGDSASSARISEPGPPSVPDAAGSSPASAVRRGLPRVRGGEPWPQATALTDSEHGAGFGRGGGIGPHSVALSESATAPGSQNAAHLADSAADSASSARISEPGPPSDPDAAGSTPAGTPGRTPAGPARAGHPLAGPTSAGSTPAGSPPAHPDPAGPSPAGSTPAGPTPAGADPAGPAPDGPTPAGPAPAPAARPPLAVPTTVWPGAAASAPRPARSEPKRIGPYTPLQWLGSAAVLGVFALALAGIAVLFARFVLAIEPGRDFLAAFPGEYALPEGAPVGLPVWLNWSHFLNSFFLLFIIRSGWQVRREKRPAAFWSPRKNKKRRISLALWFHQAIDILWIANGVIFVVLLFATGQWMRIVPTSWEVFPNAVSAALQYVSLDWPTENGWVNYNSLQQLSYFAITFIAAPLAILSGVRLSGVWPKDAEKLNRLYPVEWARKIHFPVMLFFVAFIVVHVALVLATGALRNLNHMYAARGAVDPGEYTSDPTGLLIFAASLLAMAAGWVAARPAVLVPIARLFGDVKQR
>NC_015125.1|WP_013585029.1|2071302_2071857_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MAPRGHSADDVARTALRILDDHGLPDLTMRRLATALEVQPSALYWHFPNKQTLLAELSDRIVGRMASGIPVDLGAEAHALRDALLTYRDGAEVVSSTLALGLGSSLAHDRLASAVAAAGFDADTARRGATTVLHYALGFVWHEQQRLQYDSAGARDAGASSLESDDFAFGLDLIAAGLRARGRV
>NC_015125.1|WP_013585030.1|2071926_2072523_+|biotin-transporter-BioY
MTRTLDATDLARVAVFAALIAVLGLPGSFPVFGGVPITAQTLGVMLAGAVLGPWLGALSVTVVLALTAAGLPLLAGGRGGIGVFLGPSAGYALGWILGAIVIGLLVHAGGRRPVAWRTALAMLVGGVVAIYAVGIPVQSAVTRLPLGETALTSLVFVPGDLLKAALATAVVSALVRAYPRGFRRAWTTPAARAAVASA
>NC_015125.1|WP_013585031.1|2072519_2073599_+|acyl--CoA-ligase
MIVTLDGDAPRLFERIAATRAAGDAVLIADPRWSADQRAGVERVASGIEETDATAWATLTSGSSGTPRIVRRTAASWTNSFAAVAALLDAGPDDVVALPAPPSSSLTLYSLAHALEGGPRPALGRDPAATCLHATPEGLRAVLDDGSLPRLRTALVGGSPLDRALRARAEASGVRVVSYYGAAELSFVAVDAGEGLRAFPGVDLEVRGAEVWVRSSFVASGYLGSDGPLRRDGEWATVGDRAELRDGRLRLLGRADDAILSASATVVPHEVEEVLRGIPGVRDAVVFGMPRPRVGALVAALVELTDADPAAVRAEAATRLGPAHRPRRWAFGTIPRTPSGKPARAEVARLVEHGRGAGH
>NC_015125.1|WP_013585032.1|2073582_2074689_+|thiolase-family-protein
MAPDTDPVVVAARRSPLAVRGRGLTDVDAGSLAGTVIAATVADAESPPIADVVLGNCTGPGGNLGRIAALAAGLGTGVPGGTVDRQCGSGLAAIMDAAHATRADGRARVAGGVESASTAPVRVQDGAPYARAPFAPAGFADPDMLRAAEDLAAHDALTRERQDAYARRSHARATTARASGRFDAEIVPVAGVSRDEGIGTSAALLARLAPLMTGGTVTAGTSTRIGDGAAAVVVAPAGSGPGLAIRATAVIGCDPALPGIGAAPAIQAALTQAGRSLTDVAAIELVEAFAAQSIAVLSRLGLRDDDERVCAEGGALALGHPWGASGAVAVVRLFSRLVRAGAPAGTLGLAAASVGGGLGVAAVFEVVR
>NC_015125.1|WP_013585033.1|2074685_2075372_+|ABC-transporter-ATP-binding-protein
MSVVHCRGLTARLGDREVLQDVALDLGARTIAVIGDNGSGKSTFARLITGLVRRASGELAVLGLDPERDAADLRRRVALVLSNPDAQIIMPTVAEDVALSLRALRLSREERGRRVTAVLERFGLDALADRAAHDLSGGQKQLLALAGAFVRSPDLVVADEPTAFLDARNARAVADHLLADFGHALIVVTHDLALARRCETAVLFEDGGVVASGIAADVVERYERAVAC
>NC_015125.1|WP_013585034.1|2075365_2075974_+|cobalt-ABC-transporter-permease
MLSVFRPGRGWLHRMPAGPKLALFAVVAVVVAALPPVWATVPVAVVVPVALYAVAGMGLGAGLRALGGQVCALRWMIAITAAGQLIFLGLEPAAANTARVAAAVLVAGLVPLTTPVSAMLDALERGLRPLRLVGIDPARVALLWMVTLTTIPVLARHAAEVRDAQRARGLRPSLLRGTLPFLVVALRHADDLGDALAARGIR
>NC_015125.1|WP_148272960.1|2076126_2076876_-|coenzyme-F420-0:L-glutamate-ligase
MQVWALDGIREITPGDDLVRVILDALTEPLQDGDIVVVTSKIVSKAEGRIIRASDREDAITRETVRLVASRTSPTGHVTRIVENPLGIVSAAAGVDASNTPEGTVLLLPVDPDASARRIAEGLRAVARVGVIITDTLGRAWREGQTDHAIGAGGIHVFEDLRGTVDAEGRPLVVTLPCVADELAAATDLVKGKASRRPVAIVRGRGDLVGELDLPGARSIVRDPERDMFRQGADEAYAEGFAAGRAARD
>NC_015125.1|WP_013585036.1|2076880_2077387_-|GNAT-family-N-acetyltransferase
MTAEPRTDIVVRPVRDVDAEALGRVHATCWHETYDHLISEAALKAVSPRRMAELWTHWASQGDDYRMHAALVDGEIVGFVGSGPARDDDAPRERELYFIYLLDAFHGTGIGQQLFDAAIDADEGAYLWVADDNPRAHRFYTRNGFALDGASHVEPFLGEELTEVRFVR

Crispr_ID: NC_015125_10

• CRISPR_ID: NC_015125_10
• CRISPR_location: 2203614-2203700
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_10

Consensus_repeat	Method
CCGGTGGCTTCGACGGGCTCAGCCACCT	CRISPRCasFinder

spacers of NC_015125_10

>10.1|2203642|31|NC_015125|CRISPRCasFinder
TGCTTCGGAGGTTCCTGAGCTTGTCGAAGGG

CRISPR arrays and Neighbor proteins around NC_015125_10

CRISPR arrays

The CRISPR arrays of NC_015125_10

>merge|NC_015125|10|2203614-2203700|CRISPRCasFinder
CCGGTGGCTTCGACGGGCTCAGCCACCTTGCTTCGGAGGTTCCTGAGCTTGTCGAAGGGCCGGTGGCTTCGACGGGCTCAGCCACCT

>NC_015125|10|9|2203614-2203700|CRISPRCasFinder
CCGGTGGCTTCGACGGGCTCAGCCACCT	TGCTTCGGAGGTTCCTGAGCTTGTCGAAGGG
CCGGTGGCTTCGACGGGCTCAGCCACCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013585128.1|2193642_2195166_-|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|173861
NC_015125.1|WP_013585136.1|2204042_2204891_+|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NC_015125.1|WP_013585131.1|2198777_2199143_+|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013585144.1|2213455_2214460_-|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl|CDD|224007
NC_015125.1|WP_013585139.1|2207300_2209553_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|378963
NC_015125.1|WP_043362614.1|2199173_2200739_-|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl|CDD|129794
NC_015125.1|WP_013585141.1|2210555_2211356_-|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl|CDD|224268
NC_015125.1|WP_013585126.1|2190775_2192641_-|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein	unknown	unknown	gnl|CDD|223521
NC_015125.1|WP_013585127.1|2192637_2193579_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223674
NC_015125.1|WP_013585137.1|2204887_2205820_+|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NC_015125.1|WP_013585129.1|2195354_2196020_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_015125.1|WP_013585130.1|2196016_2198446_+|DUF4982-domain-containing-protein	unknown	unknown	gnl|CDD|225789
NC_015125.1|WP_013585143.1|2212383_2213361_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|368448
NC_015125.1|WP_013585135.1|2202712_2203558_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|378820
NC_015125.1|WP_148272849.1|2202177_2202654_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NC_015125.1|WP_148272966.1|2200804_2202172_-|MFS-transporter	unknown	unknown	gnl|CDD|340863
NC_015125.1|WP_013585142.1|2211403_2212375_+|acetylxylan-esterase	unknown	unknown	gnl|CDD|225989
NC_015125.1|WP_013585140.1|2209617_2210511_+|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|380491
NC_015125.1|WP_013585138.1|2205881_2207201_+|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270303
NC_015125.1|WP_050901855.1|2214456_2215638_-|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013585128.1|2193642_2195166_-|peptide-ABC-transporter-substrate-binding-protein	gnl|CDD|173861	cd08496, PBP2_NikA_DppA_OppA_like_9, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA can bind peptides of a wide range of lengths (2-35 amino-acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	7.49705e-121
NC_015125.1|WP_013585136.1|2204042_2204891_+|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.52382e-77
NC_015125.1|WP_013585130.1|2196016_2198446_+|DUF4982-domain-containing-protein	gnl|CDD|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	7.49378e-49
NC_015125.1|WP_013585144.1|2213455_2214460_-|sugar-phosphate-isomerase/epimerase	gnl|CDD|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	1.87492e-33
NC_015125.1|WP_013585139.1|2207300_2209553_+|FAD-dependent-oxidoreductase	gnl|CDD|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	1.26366e-123
NC_015125.1|WP_043362614.1|2199173_2200739_-|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.24323e-72
NC_015125.1|WP_013585141.1|2210555_2211356_-|DeoR/GlpR-transcriptional-regulator	gnl|CDD|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.63207e-71
NC_015125.1|WP_013585126.1|2190775_2192641_-|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein	gnl|CDD|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.37783e-124
NC_015125.1|WP_013585127.1|2192637_2193579_-|ABC-transporter-permease	gnl|CDD|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.98764e-97
NC_015125.1|WP_013585137.1|2204887_2205820_+|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.57705e-87
NC_015125.1|WP_013585129.1|2195354_2196020_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.11336e-12
NC_015125.1|WP_013585143.1|2212383_2213361_+|alpha/beta-fold-hydrolase	gnl|CDD|368448	pfam05448, AXE1, Acetyl xylan esterase (AXE1). This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyze the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan.	2.39232e-127
NC_015125.1|WP_013585135.1|2202712_2203558_+|alpha/beta-fold-hydrolase	gnl|CDD|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	2.3379e-50
NC_015125.1|WP_148272849.1|2202177_2202654_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.01081e-16
NC_015125.1|WP_148272966.1|2200804_2202172_-|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.37889e-67
NC_015125.1|WP_013585142.1|2211403_2212375_+|acetylxylan-esterase	gnl|CDD|225989	COG3458, COG3458, Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism].	1.80624e-35
NC_015125.1|WP_013585140.1|2209617_2210511_+|substrate-binding-domain-containing-protein	gnl|CDD|380491	cd06267, PBP1_LacI_sugar_binding-like, ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. Ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. In most cases, ligands are monosaccharide including lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the domain sugar binding changes the DNA binding activity of the repressor domain.	2.04852e-62
NC_015125.1|WP_013585138.1|2205881_2207201_+|extracellular-solute-binding-protein	gnl|CDD|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.21626e-40
NC_015125.1|WP_050901855.1|2214456_2215638_-|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	9.72244e-63

Protein sequences

>NC_015125.1|WP_013585135.1|2202712_2203558_+|alpha/beta-fold-hydrolase
MPEFDDAYGITIVYDVYEAAEPRGVVQLLHGVGEHAGRYAALIEALVADGYTVYADDHRGHGRTGLRQWSGDHSKLGRLGPGGLGAARDAVWTLTQIIRERHPDLPLILLGHSWGSFLAQMLLDRHPDAFDAVILSGSALRWPGALNAGDLNAPWKKLGGSGMQWLSSDEQVGRDFAADPLTTSVPLAKLFGPLEAAKLFGRPRRNIERDVPMLLMVGREDTVGGPRSVHLLADAYRSRSGLTDVTTLVYPGARHEIFAEVQQAEVRADLLAWLDARFPRA
>NC_015125.1|WP_148272849.1|2202177_2202654_-|MarR-family-transcriptional-regulator
MLTTEMMTKTESTDTPDQSPVFTSTASTLRMATFRLARRLRAQRAVDSMSDGQFAVLAALTIHGEHTLGQLADRERVTAPSMNRTVSLLEEAGYLTRTPHEDDRRKVTIALTDAGRTVVDETVRRRDAWLEEALEGLSPGERQTLASAAEIMRKVAER
>NC_015125.1|WP_148272966.1|2200804_2202172_-|MFS-transporter
MFRSFSVFNYRVWFIGALVSNVGAWMQATAQNWVVLTQLTDNDAAAMGVTMALQFAPPLLLVSVTGWVADRFDRRKLIMCTQSALLALALTLGILILTGVMTLPLMYGFALALGVVTAFDNPARQTFVSDLVEKENASNAVALNAASFNTARLIGPAVAGVMIVVVGTGWVFLVNAVTFLAMLAALLIMRPHELVVHHRRGGPARLADGFRYVAKRPDLVVIFSMVFLLGAFGMNFPIFASTMALEFGRGADGFGLLSSFVAIGSLAGALLAARRERARMRVVILGSGGFAVASTLSVFAPSYGAYAATLVLTGFCVVTTLTTANGYVQTTTDPALRGRVLALYMAILLGGTPVGAPIVGWVASEFGPRVAIGLAAVVAFLACGIGVAWTLSSGRVHRHESKRFRLTVDETRPLKVVSPEPEDFSDEIAGTTPIPLAGGERAPRPGTPRPASHHP
>NC_015125.1|WP_043362614.1|2199173_2200739_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MDRRRWAGLVFISIAVSLIIVDSTIVNVAVPSIVEDLGISSTEVQWVQEAYTLVFASFLLVFGSLADRFGRRRLMLIGVVVFAVASIAASLAPTGGALIAARLAQGIGGSMILPTTLSLINATFRGRERGIAFAVWGSTIGGMAAVGPLLGGWLTTEFSWRWAFGINIPLGVIIVIGVLLTVAESRSDQRAAIDGVGALLSVLTMAPLVFALIEGRTYGWWTVDTVPTIGSWTWPFSLSPVPIAFAVAVVALAGFIAWGLRRQRRGLSTLLAFDLFRIGSFRNGNIAAAVVSLGEFGIILALPLWLQFVVGFDALQTGLLLLALAIGSFVASGVAGALSGRVAPVWVVRGGLLAEIVGVAGVALTIGPDATWGPLIPFLFVYGLGVGLATAQLTGVVLADVPPAASGQASGTQSTSRQLGAALGVAILGTVLFSTTAGVLASSLDDRGLPAAQRDQVVSQVVDSAGAAIAGLGQSPATQDIAADARAAFSDGTRAAALTAAGFLTLGLVSTLALGRRREER
>NC_015125.1|WP_013585131.1|2198777_2199143_+|hypothetical-protein
MAEKKTPQTNEELAYRLAEDPAHTLRAPGDVRTGESAAAYGREFLLREFGDEQAIQAAMRKPGRPRKATVKVAARKGPSPTVRARVTDADFDMLARIEAKTGKTESELVREGVALVIARYA
>NC_015125.1|WP_013585130.1|2196016_2198446_+|DUF4982-domain-containing-protein
MIREPFLDGWTVGPKRGAFEAQDAATLAHVTLPHDALRDLPRSPDSPQGVTSGYYPGGVFEYVREFDVPESWRDKTVLFEFEGVYRDAVVFVNGERAAHEGSGYAAFTVEADAFLRFGETNRLSVEARVHKDSRWYTGAGIHRPVHLVVADPVHLPLDGVRVTTPDIDAERAIVAVSARVRNTTRHTRTTRVSWEVRDPAGRSVATGSSPVTVLPGEVAVARARLIVERPQLWSIDTPALHELHTALADEGGAAPVDTDRTAFGIRSLQLDPVHGLRINGESVTLRGACVHHDNGPLGAVSIAAAEDRRVRLMKEAGFTAIRSSHNPAGRALLDACDRHGMVVMDELGDVWTRAKTAFDHSVRFADDWRADVEALVAKDVNHPSVILYSIGNEILEVASPHGAAWSRRLAEAVRALDDTRFVTNGINGIIANLDRIADARAELAASDPNTLMAGLGAQMAAMNASELVTRTIEESAAVLDVVGFNYADSRYALDAELFPNRVIVGSETFPERIGALWPLVASLPHVIGDFTWTGWDYLGEAGIGRVDYVDAASDAPTDTAGPYPYLFAESGDLDATGHRRTVSFFREIVYGLRTEPFLAVHRPQYYGRPTAVTPWSWDDTVASWSWDVPAGSPVVVDVYADADEVELQRDGETVGVSPVGEAREFTARFDTVYVPGELTAIARRGGVEVGRTTLRSAAGEPALVARAEAATIGAGLDDLAFVRIALEDPSDVVPCDRDVVVSVSVSGPGVLAGLGTGRARTEEPLSAASVTTYDGRALAIVRPTGAGEITVRVTAPGYPEARVLVRAGS
>NC_015125.1|WP_013585129.1|2195354_2196020_+|TetR/AcrR-family-transcriptional-regulator
MTETTRPARKPRGEYAKSEATRQAILDAALEVFAESGFRAGSLREIAQRVGMSEAGLLHHFPRKSALLLAVLDHRDEAARAVVDFDLTDGAATLHGLVELAALNASMPGVVELFCTLSAEATSPTHPAHEYFQNRYTYVRSRLTDAFERLQTAGRLFDGVIPARAAVATTALMDGLQVQWLLDPASTDMAHDLAAHFRLLVRGFDLQSLENVLDLQAGEPR
>NC_015125.1|WP_013585128.1|2193642_2195166_-|peptide-ABC-transporter-substrate-binding-protein
MFRWKATAALAVAAALVLTGCSGGGSGSEGSGSADRLTLTAIASPTSYDIGAGAEYGNRSPFFQAVFDTLLQKDSKGEIQPWLATAWEYNDDKTVLTLTLKDGVTFTDGTPLDASAVVASLERFRDGTSPQAATLAGKEFAAVDATTVTITQTAPDPSLVNLLSIAPGLIEAPSSFGNADVATNPIGSGPYILDTASSVTGTTYNYTANPDYWNKDAVKYQNLTINVLEDPTATLNAIRAGEANGAKIADNNTISEVEGAGWTIESNELDFQGLLLLDRAGTMAPQLADVKVRQAINMAFDREALLQSLQTGYGTVTEQVFPKTSVAYDESLDSTYPYDPAAAKKLLADAGYPNGFTLNMMSTPAFQQTFDLVAQQLSDIGITVNYTDPGTGNFITDMLAPKYPATWMALEQNPDWQLINFMIAPDATFNPFKYEDPKVDALISTIQTGSQAESDTAVKELNTYLVDQAWFAPFFRVQGTFATDANTNLEFWPTNAYPSIFDFSPKN
>NC_015125.1|WP_013585127.1|2192637_2193579_-|ABC-transporter-permease
MLAFIVRRLLSGVVLIAVISFLAFTLLYAAGGDIARRILGENATAETVAKKTAELGLNRPLLAQYGDWLSSAVTGNLGRSWFNGELVSVSVSGRLSVTLSIVVGATLVSAILSILLGVLAARRGGVIDAGVQFLSLVGFAVPGFLIALLLVLVFAVNLGWFKATGYTPLTTSFSGWVASVVLPIVALSIGAIATVAQQVRGSVIDATSRDYVRTLRARGLSENSVIYRHVLRNAGGPALAVLAVQFVGLLGGAVIVEQIFAIPGMGQLSVRATTQGDIPVVMGLVIAFAIIVVVVNLLIDLAQAALNPKVRLS
>NC_015125.1|WP_013585126.1|2190775_2192641_-|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein
MTAIAVPPAVPVAPVRVALFRRLLRRPLGLVSLGFLALIALLAIIGPLIAPQDPNFADIRAILASPSGAHILGTDGSGRDVLSRLLAATQTSIAAALIALVVAVVLGVVSGLIAGYYQGWFNTAATWVTELNMALPGIVVLLAARAVLGPSVWLSMVIFGILLAPAYFRLVYASVTAVRSELYVDAARVSGLSDLRIIGRHVFSVVRAPIIIQSAIIAGIAIAIQSGLEFLGLGDVNVPTWGSMLTDGFKNIYKNPVLLVWPSLAIALTCIALTLLANVLRDELERTVTVRRRRRRAVLTATGSIATATTSVALGGGDLTDPDEIPEVADGDVIVHREDARSKSTEPVLRVRDLRVGYDQADGSHIEVVHGVSLDIRKGEVHGLIGESGSGKTQTAFGVLGLLPRGGSVTGGTISFDGIDLADASERTYAGVRGKRIGYIPQEPMSNLDPAFTIGSQLVEPLRKHLHLSAKDARERSLDLLARVGIPEPKRTFDAYPFEVSGGMAQRVLIAGAISTDPELIIADEPTTALDVTVQAEVLELLRDLQQERHMAMLLVTHNFGVVADLCDRVTVMQNGRFVEQGPVRAIFNDAQHPYTRALLDAILDEGPARPPLGAENGVVA
>NC_015125.1|WP_013585136.1|2204042_2204891_+|sugar-ABC-transporter-permease
MFALLLVVPGMALMAVVVAYPLISALVTAFFRQSLVTPGREFVGFQNIVDVLESDFLRLLMQTLVFTLGTTIAPFVIGFALALALNTQIRGSKIMRGLMLIPWLVPGVVVSFLWMWIFNANYGVMNAILEPLGVAPQAWLAQPGTAMFAVIVAKTWQSFPWMMVMLLAGLQTVPRELHEAAEMDGAGTVRRFFSITVPQIGGIIGLVLLLEFIWNFQHFDIIYVLTGGGPAGSTETFATAVYETAFHGFDLGHAGALGLLWMVLLMALVVVYVRFSERGEKR
>NC_015125.1|WP_013585137.1|2204887_2205820_+|carbohydrate-ABC-transporter-permease
MTSTALPTVTPTPDAPPVVPQTPRRRRRQLASGLRSDRPGVRLAAWGAVIVCGGFALLPVYWLLATSLTPRDQVFSYPPKIFPTEVTFDAYAGLVSNPQLFTYLQNSIIVSVITAVLSVIVSAYMGYSFSKFRYRGRRQLMYFVLASQMFPQALLLVTLYSVFSAYGLLNTYTALVLSFTTFTLPLCVWMLKGFFDTIPDELIEAARVDGASRLRTIHSIVLPLAAPGLVAAGLFAFVRGWNDFIFALTLAGPDKQTLPPGLVNTYVGEAATAWPELMAASLVVSLPVAIAFMLLQRYLVSGMTAGAVKG
>NC_015125.1|WP_013585138.1|2205881_2207201_+|extracellular-solute-binding-protein
MSASSLPNPLISRRRALQLFGIGVGAAALAGCVPSGTAGPAAGAAGLNGGDPTDFSFASWSLTEESAKPALEGTLTSYEKAKGVAIKRTAFPYNEYINQLMLQVTGGQFTGAAHVDVAWLGSLAATGKLQDLSSLASGRGYTSSALQAATFDGTQYALPWTIGAIGLITNSETLGKVGVAPDAFPTTVDEFEKTLVKLKGLGGGLIPYAASTKAAQLKDILIWMQTFGSPLVDGDTVTIGDDASVEAVTWYKGLYDQGLIAADVDRFDARSLFAQGRAAMYDDAPVGRGAVTKESPDANLAAKLAPVSRPVLKAGDTPRALVWGGAIAVVNGAGAPTAGDFAQYATSDLDAILADYKLRGLPPATTEALASSEVSSDTFGAAFSERITATASSNPLWKFTAYSQIESAIADRVQAVLVGSASPKDAMKQAGEAAQKLVG
>NC_015125.1|WP_013585139.1|2207300_2209553_+|FAD-dependent-oxidoreductase
MRTHTADFDLVVVGGGLAGVSAAIAAARLGRRVALVNNRPVLGGNSSSEVRVWVCGATAHGNQRWARENGIIGELYLENQYRNPDGNPVHWDDVVLDAVRAEPNITLLLNTDVRDVVATGPEGARRIESVTGWTMGAETETVFRAPLFLDGTGDGLIGHLAGARARLGKEAREEFDEDWAPEEAERTFLGSTLLFYTKDVGHPVRFVAPDSAKAIRDTPIPSSRIIRSGDSGAHYWWIEWGGELDIVHDNERIRDELRSVILGIWDHIKNSGEFDAENLDLEWIGNVPGKREYRRLIGDYTLHQRDVLEQTRFDDGVAFGGWSIDLHPTEGMYSTGAGAVQRFSNGVFEIPYRSLYSADVDNLLMAGRDISATHIAFGAARVMATCAAMGEAAGTAAALALTHGTSPRGVYENHRVELRQLLLRQDAPLIGVADADPADLALAARVSASGARDGLGPHATAPSEPYPLAHDVGIVVPVHPRLDGIELLVASESDTELEVEVFSTGLAQNVVPEHLEHRVSVPVSAGDARWVTAPVRWEPESPANAVIVVRAQPGVTLFTTDDLPPGILTLVHTSDADDQNVHVSLDELLVQWPTKPLRGRSIVFRATAPSEALAPDRAVGGYQRPFGGPNAWASRPLAEEPAWLRLDWDEPVRPREIVLVFDDDPDVELNTLHHHRDPHLVMPSLVRDYRVEVQTVDGAWHTVAEVTDNRRRRRVHPVAPELGAVTAARVTITATNGSPEARVVAFRVQE
>NC_015125.1|WP_013585140.1|2209617_2210511_+|substrate-binding-domain-containing-protein
MTDSPSTARRVSPLTRRERTGIVALAVPNLEEPYFAELTTLLARGAEARGLSILIQQTEGDHQREIDIANGVGLPATDGLIHIPRSLTVGDLTRRTSPGPLVLLGEHIAVSPFTHVSIDNRRTADLATSHLASVGCRRVAFIGPRLSRPSDAADQRFTGYRDAVARLGIADDAGLIVAVDAFTPEEGVAALRRLHAAGTPFDGVVCSNDSVAFGVLAALHEVGLSVPEDVAVIGIDNVHAATYSVPALTSVAPDDQGIVEAAFTELDRQMAAPPGADVPVRHIVVDATVIARASTAR
>NC_015125.1|WP_013585141.1|2210555_2211356_-|DeoR/GlpR-transcriptional-regulator
MLAAERRSRLLAEVRRHGAAAVPDLAAALGVSEMTIRRDLDVLAADGHVDKVRGGARHPRPGDAPARDLTAQSRRNGAEKTAIARRAATLVEPGMSVGLSGGSSTWALARELRGVADLTIVTNSLPVADVFARPDRADEPYTQTVVLTGGVRTPTDALVGPVAVASLEHLHCDVVFLGVRGMELTAGLTTSNLLEAETNRALVAAGARAVVLADHSKWGAVGLTTIVDLNEVDLVVTDAGIAADDEEVLRAHVAELWVAPLASADD
>NC_015125.1|WP_013585142.1|2211403_2212375_+|acetylxylan-esterase
MTGATIEPGDGDYGFDLAALRAVPPVPPPSGFAQRWRSWYDEALAVDPDPRVRPLGRREGRDLFAVEHVVSGGLRLGGWFATAEDGHRTRVGIVHSHGYGGREDPEFDRVPADAAVFFALARGQGRLNTGIGAPTPAEGHVLHGIRSVDDYVLGRCAVDLWHAGTAIRALAGDVPLYLVGESFGGGIGALALPWDERLVGATLIVPSFGQYDLRLRMPCEGSGERVRQYVAAHPSAREVLRFFDASTAAGFARVPVRVEAALRDRHVPPPGQFAVANAIDAAPEAELELAVLPYGHREYDGLAEVRAAAFAATRDHISRSITR
>NC_015125.1|WP_013585143.1|2212383_2213361_+|alpha/beta-fold-hydrolase
MPQFDLPLDQLETFRPPRDEPADFDRFWADTLVEARAAGWEPRFRPVPAAESGVGGVEVDDVEFAGFGGHPVRGWLLRPRGPGGPLPCVVQYIGYNSGRGLAHQHTLLPSAGLAVLVMDTRGQTSGALPGATPDPVGSAPHPSGRLTDGLDDPAHAYYRRVFCDAVRAVDAVRAHPAIDPDRIAVWGGSQGGGIALAAAALTEGLVAAAVDFPFLSAIRRAVALTDAAPYSELVTYLQTRRGDEDAVFRALSYIDGVNFAARSSVPALFSVGLRDAVCPPSTVFAAYNHYAGEKSIRVYPYNGHEGGGPHHQLVVLGELTRRLAP
>NC_015125.1|WP_013585144.1|2213455_2214460_-|sugar-phosphate-isomerase/epimerase
MTRPITLFTGQWADLPFEEVARLAGEWGYDGLEIACWGDHLDPWRWDDDAYVQGKLDVLERNGLTVRAIANHLKGQAVCDDPIDQRHRDIVSDRVWGDGDPEGVRQRAAEEMKNTARLAAKLGVKIVTGFTGSSIWKYVAMFPPATEEMVDAGYRDFADRWNPILDVFDEVGVRFAHEVHPSEIAYDYWTAMQALEAIGHREAFGLNWDPSHMVWQDIDPVAFLWDFRDRIIHVHCKDTKKRLTNGRNGRLASHLPWADPRRGWDFISTGHGDVPWEDAFRMLNAIGYDGPLSVEWEDAGMDRLVGAPEALAFVRRLSTYEPSGAAFDAAFSRH
>NC_015125.1|WP_050901855.1|2214456_2215638_-|Gfo/Idh/MocA-family-oxidoreductase
MIGAGFMGAAHSQGWRVAPRFFDLPLSPEMSVLVGRDADRTRAAAETWGWADTSTDWREAITRDDIDVVDIVTPGDSHAEIALAALAAGKHVLCEKPLANAVDEAERMTAAAEEARTRGIRSMVGFTYRRVPAATFARDLVRSGRLGEIRQVRAEYLQDWLSDAEAPLTWRLDRDRAGSGSLGDIGAHAVDLTEFITGQRLARVSGVLETIVAERPVLASSSGLSGSAGTERGPVTVDDVALFTGRLESGALASFEATRFRTGRKNALRIEVSGSLGALAFDLERMNELEVYDATAPETEQGFRRILVTEPGHPYAGAWWPTGHMLGYEHGFSHQAKDFVEAIAEGADPRPSFADGLHVQRVLDAVARSSDADSVWVDVDTDTETSRDERTSR

Crispr_ID: NC_015125_11

• CRISPR_ID: NC_015125_11
• CRISPR_location: 2232851-2232943
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_11

Consensus_repeat	Method
AACCGGGGTGGTCCGAGCGGGCCCGCCC	CRISPRCasFinder

spacers of NC_015125_11

>11.1|2232879|37|NC_015125|CRISPRCasFinder
ACCGCAGCCCCGCCCCCAGATGAAAGAACGCGCCCCG

CRISPR arrays and Neighbor proteins around NC_015125_11

CRISPR arrays

The CRISPR arrays of NC_015125_11

>merge|NC_015125|11|2232851-2232943|CRISPRCasFinder
AACCGGGGTGGTCCGAGCGGGCCCGCCCACCGCAGCCCCGCCCCCAGATGAAAGAACGCGCCCCGAACCGGGGTGGTCCGAGCCGGCCCGCCC

>NC_015125|11|10|2232851-2232943|CRISPRCasFinder
AACCGGGGTGGTCCGAGCGGGCCCGCCC	ACCGCAGCCCCGCCCCCAGATGAAAGAACGCGCCCCG
AACCGGGGTGGTCCGAGCCGGCCCGCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013585164.1|2238476_2239493_+|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NC_015125.1|WP_013585152.1|2223177_2224227_+|lipoate--protein-ligase-family-protein	unknown	unknown	gnl|CDD|223173
NC_015125.1|WP_013585160.1|2233023_2234358_-|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270303
NC_015125.1|WP_013585165.1|2239538_2240570_-|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NC_015125.1|WP_013585155.1|2226575_2228084_-|carboxylesterase-family-protein	unknown	unknown	gnl|CDD|365897
NC_015125.1|WP_148272970.1|2246397_2247831_-|alpha-L-arabinofuranosidase	unknown	unknown	gnl|CDD|226064
NC_015125.1|WP_013585168.1|2244652_2246377_-|beta-galactosidase	unknown	unknown	gnl|CDD|366567
NC_015125.1|WP_013585150.1|2221243_2222152_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NC_015125.1|WP_148272968.1|2224271_2225198_+|site-specific-DNA-methyltransferase	unknown	unknown	gnl|CDD|334588
NC_015125.1|WP_148272969.1|2225490_2226396_+|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274648
NC_015125.1|WP_013585156.1|2228107_2229061_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013585157.1|2229419_2230571_-|galactokinase	unknown	unknown	gnl|CDD|223231
NC_015125.1|WP_193374923.1|2230567_2231713_-|galactose-1-phosphate-uridylyltransferase	unknown	unknown	gnl|CDD|238341
NC_015125.1|WP_043361299.1|2231805_2232759_+|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|380488
NC_015125.1|WP_013585162.1|2235375_2236305_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NC_015125.1|WP_013585167.1|2242859_2244488_-|PAS-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_015125.1|WP_043362630.1|2240683_2242828_+|alpha-galactosidase	unknown	unknown	gnl|CDD|307952
NC_015125.1|WP_043362625.1|2234431_2235238_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223472
NC_015125.1|WP_013585151.1|2222223_2223168_+|DMT-family-transporter	unknown	unknown	gnl|CDD|273359
NC_015125.1|WP_013585163.1|2236301_2238335_-|beta-galactosidase	unknown	unknown	gnl|CDD|367090

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013585164.1|2238476_2239493_+|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	8.10293e-89
NC_015125.1|WP_013585152.1|2223177_2224227_+|lipoate--protein-ligase-family-protein	gnl|CDD|223173	COG0095, LplA, Lipoate-protein ligase A [Coenzyme metabolism].	3.63239e-59
NC_015125.1|WP_013585160.1|2233023_2234358_-|extracellular-solute-binding-protein	gnl|CDD|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	8.58075e-50
NC_015125.1|WP_013585155.1|2226575_2228084_-|carboxylesterase-family-protein	gnl|CDD|365897	pfam00135, COesterase, Carboxylesterase family.	4.78797e-94
NC_015125.1|WP_148272970.1|2246397_2247831_-|alpha-L-arabinofuranosidase	gnl|CDD|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	1.48158e-171
NC_015125.1|WP_013585168.1|2244652_2246377_-|beta-galactosidase	gnl|CDD|366567	pfam01301, Glyco_hydro_35, Glycosyl hydrolases family 35.	5.86679e-132
NC_015125.1|WP_013585150.1|2221243_2222152_-|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	3.91553e-25
NC_015125.1|WP_148272968.1|2224271_2225198_+|site-specific-DNA-methyltransferase	gnl|CDD|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	6.4224e-41
NC_015125.1|WP_148272969.1|2225490_2226396_+|LLM-class-F420-dependent-oxidoreductase	gnl|CDD|274648	TIGR03560, F420_Rv1855c, probable F420-dependent oxidoreductase, Rv1855c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity].	3.72155e-95
NC_015125.1|WP_013585165.1|2239538_2240570_-|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.38186e-77
NC_015125.1|WP_013585157.1|2229419_2230571_-|galactokinase	gnl|CDD|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	6.42067e-112
NC_015125.1|WP_193374923.1|2230567_2231713_-|galactose-1-phosphate-uridylyltransferase	gnl|CDD|238341	cd00608, GalT, Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme contains two identical subunits. It also demonstrates that the active site is formed by amino acid residues from both subunits of the dimer.	5.63192e-99
NC_015125.1|WP_043361299.1|2231805_2232759_+|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|380488	cd01574, PBP1_LacI, ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of LacI is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	9.03498e-89
NC_015125.1|WP_013585162.1|2235375_2236305_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.40109e-50
NC_015125.1|WP_013585167.1|2242859_2244488_-|PAS-domain-containing-sensor-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.04355e-38
NC_015125.1|WP_043362630.1|2240683_2242828_+|alpha-galactosidase	gnl|CDD|307952	pfam02065, Melibiase, Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.	3.00721e-138
NC_015125.1|WP_043362625.1|2234431_2235238_-|ABC-transporter-permease-subunit	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.28922e-56
NC_015125.1|WP_013585151.1|2222223_2223168_+|DMT-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.13558e-15
NC_015125.1|WP_013585163.1|2236301_2238335_-|beta-galactosidase	gnl|CDD|367090	pfam02449, Glyco_hydro_42, Beta-galactosidase. This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	7.62011e-180

Protein sequences

>NC_015125.1|WP_043361299.1|2231805_2232759_+|LacI-family-DNA-binding-transcriptional-regulator
MADVAERAGVSAQTVSRVANGSPRVDPATRARVEKAMADLGYRMHRAARALRTGQTSTIGLVVSTLASVGNSRMLQAISEAAAARDYALAVVTVGERGIREAFARLRSQGVDGAVVLNEATELARDAQPPADLHLVVVDSPADPRFSIVQTDHAAGARAATTHLLALGCGTVHHLAGPAGSFAAVERERGWRAALADAGVAAPEPVRGDWTSASGYRAARALVGASAVFVANDQMALGALRAFADAGRRVPDDVAVVGFDDIVDAAEYRPPLTTVRQDFDALGRRAVAALIAAIEGGDAVAETVPAALVVRASSAAI
>NC_015125.1|WP_193374923.1|2230567_2231713_-|galactose-1-phosphate-uridylyltransferase
MGAGVVKRPTHLADGRELIYFDDPDTTLGAERAVDARTLDPRPTTATMRQDVLTGDWITVASNRQNRAFLPPAHLDPLSPQTPTNPSEIPSLYDVAVFENKSPSFGPALDTAIGDAPAAVDPPRGDDDLEHLGLGRTRTSVGRCEVVCFSPAHEGSFGSLSRTRARTVIEAWADRTAALSALPGIRQVFPFENRGEQIGVTLPHPHGQIYAYPYVTPRTHRLLDTISRTSNDLFERILEFESAGPRVVLRGEHWTAFVPFAARWPIEVHVLPHRHVADLAETTDAERDELAPFYLRLLRGIDALYDTPTPYIAAWHQAPVGRGRDAVRLNLQITSPRRAADKLKYLAGSEAAMGAWIGDVTPESQAERLRAALDTVPEVTA
>NC_015125.1|WP_013585157.1|2229419_2230571_-|galactokinase
MTAVDDARTLLARPPVGVWSAPGRANLIGEHTDYNEGFVFPFAIAQRTAAAVALRDDDVIRVRSTFADDAVEVPLAELDARIAAGGLGWAGYPLGVAWALLHEAPDAAPRGVDIALASEVPVGAGLSSSAAIEGAVASALNDVWNAGLDKIALARVGRIAENDAVGAPTGIMDQMASMLGVADAATFLDCRTLETRPVALGFADAGLSILVTDTLVEHAHSSGGYRERRASCEKGAEAFGVAALRDLTIDDLPRAEEILDDVTFRRVRHIVTENQRVLDTVAALDAEGPTAIGDLLTASHASMRDDFEISVPELDLAVETTLAAGALGARMTGGGFGGAAIALIPTGLIPAATEAVNAAFAASGFRAPNIFTVTPSEGARRDA
>NC_015125.1|WP_013585156.1|2228107_2229061_-|hypothetical-protein
MTDDDVLAWLTDSDPSLRWKVERDLLDAPEDQWQATRARVAHEGFGAQLLAAQGEDGLWAGGAHFPAGFEWGDPQPWTATSWSLMSLREWGVDADALRPDTAGLLERNARWEYDDLPFWGGEVDACINAFTLASGAWLGADVSGIRNWFVEHQLNDGGWNCAWVEGATKSSFHSTINSVIGILDDEWRTGGTPELHAARKGAEEYLLERQLLYRLSTGERHVWAHHLGYPFRHRYSALRALDHFRAAAQFDGTAPDPRLADAVERVRASRDADGTWHQAYPLDGAVWFPVDVDAGEPSRWLTFFALRVLRWWDGAQG
>NC_015125.1|WP_013585155.1|2226575_2228084_-|carboxylesterase-family-protein
MDAAVLATTSRGRLRGFRRGSTAVFLGIPFAQPPVGPLRFAAPVPVEPWEGERDATAYGPTAQRGDAGITLIPEPSVPGDATLNVNVFTPADRDPDATLPVLVWIHGGGYTSGSPASRWYDGDAFARDGVITVVISYRIGFDGFGLIEGAPSNRGLRDQIAALEWVRDEIGAFGGDPARVTVAGQSAGGGSVLALMASPAASGLFRGAMAISPAIGAVAVDAARGFAARLASLAGVAADRAGFASVPEERLIELQKAAGKPPRGRALASLTALLDDGLPLGPVIDGDVLPRHPLEVLGEEPSVPLVIGSTDDEFTMLTARYRAVLRFVPVSLALAVLGLGRSRRRAYLERTWRRGTAAVLGGYATDRVIRTMVLRVARARMDAGSAGATPSWEGDGMNGSTPATWVYRFAWPSPVFGDACHCLDVPFWFDHLDADGVTAIAGDAPPHDLAAQLHGAAVAFVRDGDPGWPTWDATGRRARVFDAPASVPSVESDAYAEVAPLV
>NC_015125.1|WP_148272969.1|2225490_2226396_+|LLM-class-F420-dependent-oxidoreductase
MNALAQSADDGPWTSLWVYDHFHTTPVPSAEATHEAWTLMAAFAAATDRVRLGQMCTCMGYRNPAYLAKVAATVDAISGGRAEMGIGGGWYEHEWRAYGYGFPPIAERLGRLREGVEIMHQAWTTGEATLSGKYYEVDGAIVQPKPLQDGGIPLWIAGGGEKVTLKIAAKCASYTNFGGSIEEFEHKTAVLRGHCEALGRDVSEITQSTNFNTIVAETESEAEERLAAVVARLRPHVGDERADAIEADYRSSDGFGTPEQIVERLRERAAHGLGYAIHYFPEAAYDTSGISLFEREVIPHL
>NC_015125.1|WP_148272968.1|2224271_2225198_+|site-specific-DNA-methyltransferase
MHHADNLTVTPAYADGSFALVYLDPPFNTGRTRSKAVESATWTPAADDAEGASTPDASSPDAPPEDVASDPNMLTFPEEEPPPPPVVQRGFHGREYARLRGDLRTYDDRFDDYWGFLEPRLIEAWRLLADDGTLYLHLDYREVHYAKVMCDALFGRDKFLNELIWAYDYGAKTKRRWPTKHETILVYVKNPATYFFDSDAVDREPYMAPGLVTAEKAARGKMPTDVWWHTIVPTTGREKTGYPTQKPEGVLRRMVQASSRPGDRVLDMFAGSGTLGAVAAPLGRDSVLIDDNADAVAVMRKRLEPFAG
>NC_015125.1|WP_013585152.1|2223177_2224227_+|lipoate--protein-ligase-family-protein
MHGEYKVPGGKLVVVDLEEREGRIHGFHLAGDFFLEPDDALDDIDAAVNGLPVESDVPTIAAAIRAALPEGAQLLGFTPESVATAIRRALVTAPGWADFEWEVVHDRPVSPRMNLALDEVLTTRVGAGLRKPTLRLWEWNENAVVIGSFQSFRNEVDPEGAQKHGFDVVRRISGGGAMLMAANSIVTYSLYVPASLVAGMTFADSYAFLDDWVLQALRSLGIDAVYQPLNDIAGPHGKIGGAAQKRLANGGVLHHATLSYDMDGQVLTEVLRIGREKLSDKGTVSAAKRVDPLRSQTGLPRDQVIDRFIQTFTTLYGATEGHISDEEYAEAEALVETKFATDAWLQRVP
>NC_015125.1|WP_013585151.1|2222223_2223168_+|DMT-family-transporter
MTRRPPEIVVDVLLIAVAAVWGASFLSAKELTGEVGVAPAVALRFLVAASALGVICLIRRERMPRGRGLAIAALLGCSQAAVIGLETWGVHLTSATNAGLLISLALVFTPVLESVASRSWLPRSYFVAAVAAVVGVALLVSGGGFRLPTAGDALVIAAAVVRAVHVTASGHLTRGRRDSTLAVVCVQLVVCALTSTAVAGADLPLAVGRLTASGWLDVLFLGLMCSVFAFVVQLWAVRRTSATRASILMGTEPVWALAVGVVIGGEALGLPGLAGGALIIAASYAGQAIERRHRRALAARATSGEPVLAVAPPP
>NC_015125.1|WP_013585150.1|2221243_2222152_-|LysR-family-transcriptional-regulator
MDAAHLRLLRELGDRGSVAAVAAALHISPSAVSQQLAHLQARVPVPLTVRRGRVLTLTAAGEALAAAGTRVDEALTAAREAVGAFLDSDDRPVRVSAFHSAGLALFGPLLRELDGTPPLRLADADVAHSDFPGLTADHDLVIAHRLSHDAPWPADRVVATPLLTEPLDIALPAAHPLAMRERIAAEDLADERWVSVHSGFPLAGVLDHLAAHLGRPLDIAHRINEFSVTAEVVRAGAAIAVLPRTTARPLAGDGLVLKPLADLALVRHVDALARPDALAYAAVRRVLRALRAVAGRAAEAAG
>NC_015125.1|WP_013585160.1|2233023_2234358_-|extracellular-solute-binding-protein
MKHKLFTATAGVALSALLLAGCAGGGSSSGDGAAAAADCAPSDGPVTLEFTSWIPGIEKVVDMWNTENPDIQVKVQTGPNGNNGTYQNFFNQIAAGNAPDLGQIEYDALPNFLVQDGVENIAGCSDVVAAKDQFVGWAWNQVALGGEGGVYGIPQDIGPMGLFYRSDLFEKNNIPVPTTWDEYTEAAKKIRALGGYITNFSQSDINQFAGFVWQAGGQWFGNDADGWTVSLTDPASKKVADYWQSLIDQDLVSTYPAWTDEWNNAYNSSQVWTWNSAVWGANSISSGAPDTAGNWSVADLPQWKAGDAVSGNWGGSSIAVLKGSKHPYEATKFALWLNTSTEALTALNEEANIYPATTEGLKLPSLAKGVDFYGGQKIYDVFAKAATEVTPDFVWGPTMTKTYADVSDGFKAAVSGSGTLADALQKGQDATITALESQSIPVKK
>NC_015125.1|WP_043362625.1|2234431_2235238_-|ABC-transporter-permease-subunit
MLVMAVFTVYFLLPLWWLLVASSKSTGDILTTNPLWFADMRLFSNIGDLFAYRDGIFLRWLGNSLLYAGLGGAVATLLAAMAGYALAKYRFPGRELIFDVVLGGVLVPATALALPLFLIFSQVQLTNTFWAVFLPSLVSPFGVYLARIFAASSVPDELLEASRLDGAGEIRTFFTVSLRLMSPALVTMFLFQFVAIWNNFFLPLIMLRSEELFPVVFGLYGWNNQLNQIPELRGLVLIGALLSVIPLIVIFLLLQRFWRNGLGTGALK
>NC_015125.1|WP_013585162.1|2235375_2236305_-|sugar-ABC-transporter-permease
MTTTVPAPARAERPSVPHPRRPRVPFKGAIAALLAPFAVLFLLFYVLPIIFAIGQSLLVVRREGTFGKAELVFGGLAQYALVFQDEAFWTSMLRMLTFGVVQVPVMLGLALVFALLLDSPLLKGKRFFRLAFFVPYAVPGVIAAIMWGSLFSPNLSPFTALTKNVDFLGADLVLWSIANVVTWVYVGYNMLIIYSSLLSIPSEIYEAARLDGAGQFRIAWSIKIPLVRPAIVMTAIFSIIGTLQLLAEPQVFRSFSSAVTSTFTPNMTVYATASIPNANLAAAFSVVLAVTTFVLSFGFMKWMQKKGNA
>NC_015125.1|WP_013585163.1|2236301_2238335_-|beta-galactosidase
MLAVDRLAPETRQGSPLEPLTRDGLVFGCDYNPEQWDRAVWDEDMRLMRQAGVSLVAVNIFGWSWINPAPGVWSFDELDEVMDLAHAHGIRVNLGTATASPAPWVTTRHPEILPVAEDGTRRFPGGRQAYCPSSPVFRAYAAEVSRRVVERYADHPALAMWHVSNELGCHNSLCYCDASAAAFRGWLEARYGSIAALNTAWGTSFWSQRYGAWDEILPPMTALSLRNPAQLLDFQRFSSDQQLELYRAEAEAIRRHSTAPVTTNFMVTAHIRTLDYWSWAGEMDVIANDHYLDRRLADPTAELSFAADLTRGLAGGTPWLLMETSTGAVNWQPHNLAKGEGELLRNVVSHVARGADGICFFQWRASAQGAEKFHSALLPHAGTDTAQWRTVLEVGETLRRLQPVAGSQVHSDAALLFDWESWWSLENEGRPSEDVRYLDQVHAAHAALTGSGVSVDVVSAHDELTGYRLVVVPALHLVRDEDAARIARFVEDGGTAVITFASGIVDEDDRVRLGGYPGAFRDLLGIVSEEFAPLGPGQTVTLDDGGTASVWAERLRVTDAEVDARFLDGPAAGLPARTRRAVGEGSAWYLATLPSAADYRALLSRAAQDAGIPTTPVPLGVDVIRRVSADRAFLFVINHTTDTVEIAARGRDAISGEAIAGPVRVAGGAVRIIEEAS
>NC_015125.1|WP_013585164.1|2238476_2239493_+|LacI-family-DNA-binding-transcriptional-regulator
MTPPPPGRRRSTVHDVAKVAGVSRGTVSRVLNGGYVSEQAREAIQTAIREVGYVPNTAARNLVRQRTQAVGFIVHEPHSLFLEDPNIGGIMLGANTALSNADYQMVCVVVDTERDTDRVARYLSGGFVDGAVIVSARHHDPITDVVERLGLPVAYVGHPPGINRPWVGIDNHGAARALTQRLRETGRRRIGMIAAALDRDSGSDRLAGFRDALGDDFDENLVESVPLYAYADGEAGMRRLLERAPNIDAVFGASDAVAAGALQALRAAGRRVPDDVGVVGFDDSAWASRTDPQLSTVDQPAEGLGAAAAEAVLLQLSGGIAEADGILLDAPIVWRASA
>NC_015125.1|WP_013585165.1|2239538_2240570_-|LacI-family-DNA-binding-transcriptional-regulator
MSDALPPHRRGGSRPRIVDVARAAGVSAQTVSNVLNERPGFTPETRERVLAAVRSTGYIPDPAGRHLRTGRSRRVGFSMSRSDLDPRNPFTLAFLDAVLSTAAQLDQRVLVYTHDVHVEGAFRADAGRGETDGFVLANSAPGDPRVAILEELGIPYALMGRTLPAQAQAWVDIDNAAAIASAVDHVIAAGRSRIAYVGHDSDVPWIRERERGFVDALERHGLSLPAPWRLTGSVAQLRDRLDAVFAGAEIRPDALVTASDSLALLTVDVARRHGIAVGSELAVTGFDGGALATLARPHLTTVEIPVPAIADRVVRRLLGRIDGTDDAASGEIFATRLVVAESA
>NC_015125.1|WP_043362630.1|2240683_2242828_+|alpha-galactosidase
MTTAAGPRAVHVRRGGTSLIVRLDDDALPTILHWGPEVPAGDEDELLVATAGPVGDSLVQAQPQVGVLPLHSRGWLGHPGLRGSRAGRAWSFDPSTVTHDVGDTPGEPARLVSVAVDEVDRLEVTTELLLEPSGLVRVRAGVRNLGDADYELTVLEPALPVPAVADEILDMTGRHAHERHPQRGAFRQGRWTREAWGGRPGHDSATVLCAGETGFGFRRGLVWGVHLAWSGNGAVSAERTATGWRMLSGGEKPLPGEIVLAPGESHESPWLMGSWGRGLDALSHRFHEYLRARPSHPRVERPIILNTWEAVYFEHDLARLRDLADRAAELGVERFVLDDGWFTGRRDDTAGLGDWQVDADVWPDGLGPLADHVHGLGMQFGLWFEPEMVNLDSHLARRHPEWVLQSSHGPGLPSRNQHVLDLGREEAFAYVLDAMSTVIERHRIDYLKWDHNRPLVDAGHGPDHTPGVHAQTLAAYRLMDELKRRHPGLEIESCSAGGGRIDLGVMQHADRVWVSDCIDAHERQRLQRWSSLLLPPELLGTHVGADRDHTTGRVLDLDFRAGTALFGHFGVEWDLAKADPAQLAQLRRWIELHKELRPLLHHGTVVHADGTNPAVEVEGVVAHDGSDALYRMSTVDHSAQWPLGRITLPGLDPERRYRVTVQEPSAPDSTRHPVPAWMAAGVTLTGASLETIGVATPLTDVDRLILLRARAVDA
>NC_015125.1|WP_013585167.1|2242859_2244488_-|PAS-domain-containing-sensor-histidine-kinase
MPLFEMEASPRGRMRVFLRAQFPFLLAVVFMVGIAGLTEPATLTAPVVIAGFLLTIVASVLSLVVPWERLPRGWMMLIAGLDFVAVALIRAELLPLFPSVSVLAMFPVLWLAYGFPWYGIIAAVFGAGFITSFRFAYVGSWPSSPTEWANVVIMPTFIVGVAVIVFVAARQLRRRSRQVMRAARAQADALEDARDTEAVALGIVDTVSAGVVFYDAEGHLEVANERAHHFAELGGFRLDEPPMAGRTVFSADRSTVVPANEQVIPRALAGEAVSDRFEWWGPEEAAVAVLASSGRVHRPDGAVRGTVVVIYDTTVLAEAIELREQFLRTVSHELRTPLTSITGFLDLIEEEVDPENTRLRRHIDVVTRRTADLSRRVRDLFAASESEKTLRREDVDLGDVVGAAVAEAGALAEARGHTIDTAATGPTPARLDRAQVVVAVAELLTNAVKFGIPSAPITVSYGVRDGRAVLAVTNSGPGLARTEQRRAFERFYRGSLARTGEIQGFGLGLTNVRAIAVAHGGTVRIDSVPDERTTVTLDLPAG
>NC_015125.1|WP_013585168.1|2244652_2246377_-|beta-galactosidase
MTTFTIGETDFLLDGRPHQVISGTLHYFRIHPEHWADRIRTAKAMGLNTIETYVAWNAHEPVRGEWDATGWNDLGRFLDLIAAEGLHAIVRPGPYICAEWHNGGLPVWLTSTPGIGIRRSEPQFVEAVSEYLRRVYEIVAPRQIDRGGNVVLVQIENEYGAYGSDKEYLRELVRVTKDAGITVPLTTVDQPMPWMLEAGSLPELHLTGSFGSRSAERLATLREHQPTGPLMCSEFWDGWFDWWGSIHHTTDPAASAHDLDVLLAAGASVNIYMVHGGTNFGTTNGANDKGRFDPIVTSYDYDAPIDESGHPTAKFHAFREVIAKYAPVSGDVPPARPAAPAFEAALTAEGDWMPSAQDAEPTDAPRTFEQLGHLGALVRYDVDLPALPDDRAVLAAAEVRDLAWIEVDGVPVGRLSRSLNERALAIPTGTRLTVVVEDQGRVNYADRLGEAKGLIGPVTLNGSPLTGWLSTPVDVTAVTGAGGDGIGRAAFRGSFDLDAPADLFLDTSAWGKGYAFVNGFFLGRYWRTTPQNTLYVPGPATRAGANEIVVLELEQVGETVARFVAEPSLGQLEE
>NC_015125.1|WP_148272970.1|2246397_2247831_-|alpha-L-arabinofuranosidase
MGRCVYDGIHSPGHETADAAGFRGDVLALVRELGATVARYPGGNFVSGYRWEDGVGPRDERPARLDAAWHSTETNQVGLHEFADWADAAGLEVMEAVNLGTRGVAEAADLLEYANHPSGTALSDRRRDNGREDPFGIRLWCLGNEMDGPWQIGHKTAEEYGRLAAETARMMRFIDPTVELVAAGSSNHEMPTFGEWERTVLRHTAGLVDHISVHAYYEEDPTDPASFLASGAALDRYIGEVADIIDEVGATTPDGHPIGISVDEWNVWNQTRWNEVDKPRVFTGDWPIAPRLIEDDYTVTDAVVVGSLLITLIRRSDRVSMANLAQLVNVIAPIRTEPGGGAAWRQSTFHPFKLTAEAASGRVVEPRVEGATIETARHGAVDAIDTVATVDGRDVTVFLAHRDLEASTEIELDLGVVEGIEAIVVTIPEGGDRHTTNSAGAEPVAPVALDVRVGEDGILRFTLPALAWARLRARLAG

Crispr_ID: NC_015125_12

• CRISPR_ID: NC_015125_12
• CRISPR_location: 2558762-2558882
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_12

Consensus_repeat	Method
GTTCCGCGCGACGAGATGATCCGGATCTCGCGCGGCGAGTGA	CRISPRCasFinder

spacers of NC_015125_12

>12.1|2558804|37|NC_015125|CRISPRCasFinder
TCCTCGGGCCCGAAAAGGGGCCCGGCGAAAAGACTCC

CRISPR arrays and Neighbor proteins around NC_015125_12

CRISPR arrays

The CRISPR arrays of NC_015125_12

>merge|NC_015125|12|2558762-2558882|CRISPRCasFinder
GTTCCGCGCGACGAGATGATCCGGATCTCGCGCGGCGAGTGATCCTCGGGCCCGAAAAGGGGCCCGGCGAAAAGACTCCGTTCCGCGCGACGAGATGATCCGGATCTCGCGCGGCGAGTGA

>NC_015125|12|11|2558762-2558882|CRISPRCasFinder
GTTCCGCGCGACGAGATGATCCGGATCTCGCGCGGCGAGTGA	TCCTCGGGCCCGAAAAGGGGCCCGGCGAAAAGACTCC
GTTCCGCGCGACGAGATGATCCGGATCTCGCGCGGCGAGTGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013585434.1|2547722_2548874_+|AMP-binding-protein	unknown	unknown	gnl|CDD|236108
NC_015125.1|WP_080575510.1|2560414_2561275_+|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NC_015125.1|WP_013585438.1|2550676_2552470_+|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	unknown	unknown	gnl|CDD|236020
NC_015125.1|WP_193374924.1|2567037_2567745_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|379207
NC_015125.1|WP_013585439.1|2552630_2553488_+|polyphosphate-kinase-2-family-protein	unknown	unknown	gnl|CDD|274737
NC_015125.1|WP_013585436.1|2549855_2550194_-|DUF4229-domain-containing-protein	unknown	unknown	gnl|CDD|379415
NC_015125.1|WP_013585445.1|2559047_2560313_+|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270453
NC_015125.1|WP_013585435.1|2548880_2549852_+|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	unknown	unknown	gnl|CDD|235695
NC_015125.1|WP_013585450.1|2564294_2565257_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|225176
NC_015125.1|WP_167539374.1|2568200_2568341_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013585441.1|2554929_2555493_+|DUF402-domain-containing-protein	unknown	unknown	gnl|CDD|226087
NC_015125.1|WP_013585453.1|2567783_2568191_+|NAD(+)--rifampin-ADP-ribosyltransferase	unknown	unknown	gnl|CDD|378815
NC_015125.1|WP_013585451.1|2565277_2566972_+|AMP-binding-protein	unknown	unknown	gnl|CDD|341278
NC_015125.1|WP_013585443.1|2556327_2557389_+|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|223220
NC_015125.1|WP_080575509.1|2555559_2556222_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|234689
NC_015125.1|WP_013585449.1|2563575_2564199_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013585437.1|2550268_2550673_+|PLDc-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|379161
NC_015125.1|WP_148272977.1|2561339_2562179_+|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NC_015125.1|WP_080575417.1|2553525_2554845_-|chorismate-binding-protein	unknown	unknown	gnl|CDD|224091
NC_015125.1|WP_013585448.1|2562190_2563459_+|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	unknown	unknown	gnl|CDD|236947

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013585434.1|2547722_2548874_+|AMP-binding-protein	gnl|CDD|236108	PRK07824, PRK07824, o-succinylbenzoate--CoA ligase.	3.00242e-80
NC_015125.1|WP_080575510.1|2560414_2561275_+|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.40094e-64
NC_015125.1|WP_013585438.1|2550676_2552470_+|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	gnl|CDD|236020	PRK07449, PRK07449, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Validated.	1.06153e-109
NC_015125.1|WP_193374924.1|2567037_2567745_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|379207	pfam13472, Lipase_GDSL_2, GDSL-like Lipase/Acylhydrolase family. This family of presumed lipases and related enzymes are similar to pfam00657.	1.94201e-17
NC_015125.1|WP_013585439.1|2552630_2553488_+|polyphosphate-kinase-2-family-protein	gnl|CDD|274737	TIGR03709, PPK2_rel_1, polyphosphate:nucleotide phosphotransferase, PPK2 family. Members of this protein family belong to the polyphosphate kinase 2 (PPK2) family, which is not related in sequence to PPK1. While PPK1 tends to act in the biosynthesis of polyphosphate, or poly(P), members of the PPK2 family tend to use the terminal phosphate of poly(P) to regenerate ATP or GTP from the corresponding nucleoside diphosphate, or ADP from AMP as is the case with polyphosphate:AMP phosphotransferase (PAP). Members of this protein family most likely transfer the terminal phosphate between poly(P) and some nucleotide, but it is not clear which. [Central intermediary metabolism, Phosphorus compounds].	8.88076e-142
NC_015125.1|WP_013585436.1|2549855_2550194_-|DUF4229-domain-containing-protein	gnl|CDD|379415	pfam14012, DUF4229, Protein of unknown function (DUF4229). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 122 amino acids in length.	4.31232e-08
NC_015125.1|WP_013585445.1|2559047_2560313_+|extracellular-solute-binding-protein	gnl|CDD|270453	cd14750, PBP2_TMBP, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose; possesses type 2 periplasmic binding fold. This group represents the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.64548e-75
NC_015125.1|WP_013585435.1|2548880_2549852_+|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	gnl|CDD|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	2.27786e-103
NC_015125.1|WP_013585450.1|2564294_2565257_+|alpha/beta-hydrolase	gnl|CDD|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	1.691e-24
NC_015125.1|WP_013585441.1|2554929_2555493_+|DUF402-domain-containing-protein	gnl|CDD|226087	COG3557, COG3557, Uncharacterized domain/protein associated with RNAses G and E [Translation, ribosomal structure and biogenesis].	3.55366e-07
NC_015125.1|WP_013585453.1|2567783_2568191_+|NAD(+)--rifampin-ADP-ribosyltransferase	gnl|CDD|378815	pfam12120, Arr-ms, Rifampin ADP-ribosyl transferase. This protein is found in bacteria. Proteins in this family are typically between 136 to 150 amino acids in length. The opportunistic pathogen Mycobacterium smegmatis is resistant to rifampin because of the presence of a chromosomally encoded rifampin ADP-ribosyltransferase (Arr-ms). Arr-ms is a small enzyme whose activity thus renders rifamycin antibiotics ineffective.	1.19716e-65
NC_015125.1|WP_013585451.1|2565277_2566972_+|AMP-binding-protein	gnl|CDD|341278	cd05974, MACS_like_1, Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS). MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.	0
NC_015125.1|WP_013585443.1|2556327_2557389_+|polyprenyl-synthetase-family-protein	gnl|CDD|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	1.09836e-77
NC_015125.1|WP_080575509.1|2555559_2556222_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	2.12799e-112
NC_015125.1|WP_013585437.1|2550268_2550673_+|PLDc-N-terminal-domain-containing-protein	gnl|CDD|379161	pfam13396, PLDc_N, Phospholipase_D-nuclease N-terminal. This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, pfam00614. However, a large number of members are full-length within this family.	3.1941e-09
NC_015125.1|WP_148272977.1|2561339_2562179_+|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.3066e-74
NC_015125.1|WP_080575417.1|2553525_2554845_-|chorismate-binding-protein	gnl|CDD|224091	COG1169, MenF, Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	3.04713e-87
NC_015125.1|WP_013585448.1|2562190_2563459_+|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	gnl|CDD|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	4.39368e-170

Protein sequences

>NC_015125.1|WP_013585443.1|2556327_2557389_+|polyprenyl-synthetase-family-protein
MTPRLPAASTRLSGKLGLSDRIFAGLRSRTLLSTVEAGLGRVESTLEEEVRSADRLADVTARYLYEAGGKRVRPMLAILTAQLGRGTTPEVIEVATALELTHLGSLYHDDVMDGADKRRGVPSAQTVWGNNIAILTGDLLFSRASQLMARRGERAIQLQADTFERLVLGQMHETVGPQEGDEPVEFYLRVLADKTGSLIAAAAQCGVIYSGAPEEFEQPMVVFGEKAGVAFQLLDDVIDLSPDASETGKVPGTDLRAGVPTMPYLLLGHRSDAASADLRGRIDEGQERIAAGADPAILDAPLAELRDHDTTHETLRLAHQWSQEAIDALAPLPDGAVREALTRFARAVADRSA
>NC_015125.1|WP_080575509.1|2555559_2556222_+|class-I-SAM-dependent-methyltransferase
MFDQVAPAYDRTNTVLSLGNDRFWRAATLRAVAPKRGERILDLAAGTGTSSMAFVPSGAHVVAADFSRGMIAEGRRRHGNVPNLEFVQADATDLPFEDGEFDAVTMSFGLRNVNDPRRALRELRRVTRPGGRIVVCEFSHPPSRAFNGLYRFYNDRILPLAARAVSSNAEAYDYLNESIRDWPDQPTLASWMRDAGWDAVAYRNLSFGIVALHRGIRPAE
>NC_015125.1|WP_013585441.1|2554929_2555493_+|DUF402-domain-containing-protein
MDVRPAPGTRLMFRWRKWDGSPHWVQDSVYLGSDHWGDWFGQQVGWRSARPGAEFVCRQPNVTLVPASGDWAFTHNAAPHPVAVYIDLAWDIRWSDEGVPLGIDMDLDVVRRTDGRGTWIDDRDEWDEHRVRYGYPADIVAHLEATAVDLEHRVREGIAPFSDAVTGPWLARLAELATPEDPAPSPA
>NC_015125.1|WP_080575417.1|2553525_2554845_-|chorismate-binding-protein
MPRTPAETGSTLEGVIEPADDVVPRLRVVTRELPPMDDVLAYTTPYDPLLWSRRGESLAAFGDLLTLRYRGARPGDASVADRWRAIAAAAEVDDPVQLPGTGLVAFGSFVFDPRSERESILRVPGTIVGRHSGRAWVTRLAFDDTPDEPEPELPPRSPFGPHWSATLGPGRQTAEGYQDAVRRGVEAIDAGEVGKVVLARDITGTIPAGSDLRRLVRSLHEGYPDCWIFAVDGLIGASPETLVTVSRGTVTARVLAGTVARGADADADAAASLALSESTKDQEEHRFAVQSVLTALRPHTSALAAAEQPFTLKLPNVWHLATDVEGVLSEAASSLDLVGVLHPTAAVAGTPTDVAIEVIRRLEPFDRGRYAGAVGWIGASGDGEWAIALRCAQIDRAEPSSPTAPITAYAGAGIVADSVPESELLETRVKFRPIVDALA
>NC_015125.1|WP_013585439.1|2552630_2553488_+|polyphosphate-kinase-2-family-protein
MSTSSRWSVPPSVALSVEPGFRLADLDTRATPGYDGKKADGQADLEAGIAPLSGLQERLFAQSVAGTATGSVLLVLQAMDTAGKGGIVRHVVGAVDPQGVELASFKKPTAEELSHDFLWRIRKRLPDAGRIGVFDRSHYEDVLIGRVRRLAPADEIERRYGAIVGFEAEAADLGIRVVKVMLHISKDEQRARLAERLERPDKHWKYNPSDVDERELWDDYMDAYQAAIERTSTPLAPWHVIPADRKWYARLAVQRLLIDALTDIDPRWPTADYDVEEEKRRLAAS
>NC_015125.1|WP_013585438.1|2550676_2552470_+|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase
MSTTAERAAAPSTDAAAALLAGLVARGVRHLVISPGSRSQALALVAADLERAGLVHLHVRIDERVAGFTALGIGRETGMPAVVVCTSGTAVANLLPAALEAHHAGVPLLLLTADRPPELRGVGANQTTRQPGLFRAAARFEADLPVPDAVDHDGTAEQTAEFDTVAATALAAALGEGARAAGPVHLNVPLREPLAGAVPGWLLERATARPVAAASDIESDPEAEASGALYQGGGGIGVADVAPETEAAFPLELGARTIVVAGADAGPAAEELAHRGGFPLVAEIVSGARFGRNVVHGYRALLRDPDLGGRIERVVVLGHPTLSREVALLLGRDDVEVIAVRGPGEPVNLNGTTQGVDAVRVTSGETDRAWLGEWMRASRAAAVDLSPPAPDADGLASAVPHERLGAINAEVEVIRAPLDRAALVDALWRATWPHDRLMFGSSRLVRVADELLSGKKVSVHANRGLAGIDGTIATATGIALASQVEERPGVTRVLLGDLAFLHDLGALLLPPGEDEPRLQVVVGNDGGGTIFDGLEVASVAGDDAMDRVQYTPHTTRLEPLALAFGWEYHRVTTRVALDQVLTAPGGGRQLIEVPLPR
>NC_015125.1|WP_013585437.1|2550268_2550673_+|PLDc-N-terminal-domain-containing-protein
MARLLLILALVATAFWVYTIVDCAVQPSTRHRGVSKGAWMVIVILLPVLGGILWFIVGRGRAGGPVLRRAPDDDPEFLGRLSPAARADQDERIRRLEEELAQLDSEADDPRDPRPKTGDDPGDDDARGQRGAVS
>NC_015125.1|WP_013585436.1|2549855_2550194_-|DUF4229-domain-containing-protein
MRARSALVYTVLRLLAFVIPLGILLLFPVFQELPWLAAVFAALIGLSLSLLFLRRPLDQVTGGLAERRAARTATGRRSGAEADADAEDAVLDASAPPTDAAAEPAKPETTER
>NC_015125.1|WP_013585435.1|2548880_2549852_+|1,4-dihydroxy-2-naphthoate-polyprenyltransferase
MAAQSRKRSRPAPKRRPHGNPQKHKSGAPQAVAPATARDWIAAARLRTLPLAITPVLIGTGAASLVDDQLHWALALACLAVAFALQIGVNYANDYSDGIRGTDDVRVGPGRLTGGKKAKPRTVLLVALAFFALAALVGLAIVVRTGQWWLLAVGAVCIVAAWFYTGGKRPYGYNAMGELFVFVFFGLVATLGTTWVQVQSIPQEAWFGAVAAGLLACAVLLANNLRDIDQDRLAGKRTLSVLIGRRATQVLFTLFVIAPFVISAFLALFYPVAWLTLIALLGALSSVLIVWTYRTPRELITALQVTSFTSVAYGALLFWAFLA
>NC_015125.1|WP_013585434.1|2547722_2548874_+|AMP-binding-protein
MKLEPPASGDPRDVLRALRAAVLGAGPAVALGGTDLPVEVPAGTAAVVTTSGSSGVPKSVVISRNALISSAYATASRIGEGAWLLAVPATYVAGVQVIVRALLADREPAVVAGPFRPEPFAAAALGMASHADGARVPSYTSLVPAQLQRLLDAAEHDDAVAQALRSFEAILIGGQALAPAVHERAVAAGARIVRTYGSTETSGGCVYDGVPLDGVELAIVDGEVRLSGPTLADGYLGEPERTASVFPIDDEGRRWYRTGDGGAIVDGVLRVTGRLDNVIVSGGVNVSLDRVEAAVRGIRGLESAVVVAIPDATWGQGSAVVLPGLAPDAAAETLARVRDAVAEQVGPAARPARVIAVDELPMLSSGKPDRTALARRYGGAGLG
>NC_015125.1|WP_013585445.1|2559047_2560313_+|extracellular-solute-binding-protein
MRKLGRIVAGASALVLAGTLGACSADDGVPTLTWYINPDDGGQAEIAASCTEAADGAYRIETSLLPRDAASQREQLARRLAASDRSLDIMSLDPPFIPELAEPGFLAPVPDDLQNTDGIVEGAVQSASWNGELVTVPFWANTQLLWYRKSVAEAAGLDMTQPVTWDQIMQAAEDQNKQLGVQGALAESLTVWINALVASGGGKILEDPEAKPDEMQLGLESDAGKKAAEIIGRIGSSGLGGAGLPTADENASMNLFQGDNGSFMVNWPFVYPAMQGAAPDVVEDLGWAVYPRVDAGTPAAPPVGGINLGVGAYSEHVDLAWQAVQCIVTPENQAQYFVTNGNPPSNLAAYDDAEVTEKFPMADTIAESLQLGAPRPQTPYYNEISIGLQRTWHPPNAVNPDTTPQSSTDFILAVLRGERLL
>NC_015125.1|WP_080575510.1|2560414_2561275_+|sugar-ABC-transporter-permease
MLAGPAFGIMLLVTLYPIVQALWDSLFSLRLTAPDDREFIWFRNYQVILGDPAFWQSMGVTLFITVVTVLLELIIGFGFALVMHRAIKKLRGFARTAILVPYGIITVVSAFAFFYAFDINSGGYVNSWLSWIPGFDENLNWFAYQGTSLTVIILSEVWKTTPFISLLLLSGLAQVPGDLEEAAKVDGATGWEVLRRVILPNMKAAIMVAVLFRTLEAFRIFDNIFIMTAGANDTEALSLLAYNTSIGRLEIGLGSAISVLLFLSVLIIAGIFIKGFKVDLSAGKNS
>NC_015125.1|WP_148272977.1|2561339_2562179_+|carbohydrate-ABC-transporter-permease
MTWPQRIMWLVIIAAVLVWSLFPVFSIAMTSFKTQAGLFSGTLLPQEWTLDNYATILAPGGSAQDLFLPALRNSIGISLIATFVAVVLATLCAYAIARLDFPGKRIILTTALAVSVFPIVSIVTPLFNLWRVIGLYDTWLGLIIPYLSLTLPISIWTLAAFFRQIPWELEQAAQVDGATPFEAFRKTVVPLAAPGVFTTAIIAFFIAWNDFVYGISLTSTDAARPVPAALSFFTGASQFEEPTGAISAAAIVVTIPIVIVVVIFQRRIVSGLTQGAVKG
>NC_015125.1|WP_013585448.1|2562190_2563459_+|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC
MASITLNRIVKTYDDGFTAVKGVDLDIADGEFVILVGPSGCGKSTLLRMIVGLEDISDGELRIADEVVNDKAPKDRNLAMVFQNYALYPHLTVYENIAFPMRLKSSDLSDKEIDERVRRASKLLELDEHLERKPANLSGGQRQRVAMGRAIVRNASAFLFDEPLSNLDAKLRGQMRTEIARLQRSLGITTVYVTHDQTEAMTLGDRVAVLRRGELQQVASPRGLYDQPVNLFVAGFIGSPPMNFLSGTVDGDTLRLPIADVPLDDRLRKAVEGRDLVIVGVRPDAFEDADSTERDLSGGITAELDIEMTEWLGEVLYAYVPYETDATVKDKLSELDRDLDGESLRTELVVALDAMSSIRAGDAARLWFSPDSLHLFDPETGVNLTRDEAKAEKLEEDARAARKRALERAKERAAREDASAPR
>NC_015125.1|WP_013585449.1|2563575_2564199_-|hypothetical-protein
MHPRNWLVPALSVAVGSLALGGLTSFGQTVLPDALASFANSAGGWTILAFGLVWLTRARPPLAAALGVVSFVLLIEGYRIVSAWRGFFYAEPFQDTFTIIGLFAGPVVGLSASLLRWGPGSWKPFAAAPVAAVLIGEGVYGLTVVGATTSPVYWILQTVIGVALLVSTVVAARPRIAPGVLGSVLTVGGAAAFLGFYAWMGQLGSTV
>NC_015125.1|WP_013585450.1|2564294_2565257_+|alpha/beta-hydrolase
MGEWHPDILGEGFEQQTLPLGSDDEGEVVATLVRAMPHPGARLFGAWRDLDVLYVHGWSDYFFQADLARFFTDRGARFYALDLRKYGRSIRPGQTRGYVLALDVYDADIEAALDVMGTEARGRRLVLLGHSTGGLTLTLWAARHRGRAHALVLNSPWLELQLGPLGRQALAPIVNARARLDPRGGQLALDLGFYGRAQREVGTLPDSPEGWRPPRAFPTHPGWLAAVIAGHARVASGVDVGCPALVLLSLRSTTSLTWNDAMRETDSVLVVDDIARAATRIARTVTIARIDGALHDVFLSAPDAQDAAYAALGNWVRGLA
>NC_015125.1|WP_013585451.1|2565277_2566972_+|AMP-binding-protein
MIPTVSATERYRAARDELLAARTDPDRAAAFTWPRFDGPFNWAIDWFDPMARGNDAPALIVVDDDGTHHQRTFDELARRSDQVAAWLASRGVRRGDAVLLMLGNQVELWEAMLGIMKLGGVIAPTTTALGARDLADRIERAEIRHVIVGAADADKFDDLPEGLGRIVVGGEHPGWAAYEEAFLAEAGPARHPGTVADDRLLLYFTSGTTSKPKLVEHTHASYPVGHFTTMYWLGLQPGDVHLAISSPGWAKHAWSLFFAPWIAGATVLALNYSRFSAERLLDELERDRVTTFCAPPTVWRMLIQADLTGRRGALREVVSAGEPLNPEVIATVQRAWGLDIRDGYGQTEMTAVVANTPGAELVPGSMGRPLPGCPVVLIDPVTGEPADEGEICLDLSERPLNLMTGYVGDAERNDESTANGLFHTGDVARRDALGTITYIGRTDDVFKSSDYKISPFELESVLIEHPAVVEAAVVPAPDDLRLSVPKAYVVLASGFEPGEDVAIDILRYAREKLAPFQRLRRVEFLELPKTISGKIRRVELRQREEAVVRGEVTPVEWRDDALRG
>NC_015125.1|WP_193374924.1|2567037_2567745_+|SGNH/GDSL-hydrolase-family-protein
MLTRGGTDATPAASATSTSPERTATPTRTPSPSPTRTATPTPTPTTPGLLRIPRDAAGDARVLITGDSLAAGFFASTEAQGFSALVTGALGRVTPTTVSRAHETLSTVAGVTDVPADLGLAVIELGTNDVGIPTPLADFEAQYAELVGRIRTSSPRAAIVCTGTWTVDGAEYDGIIAGVCTANAGRYVSLADLFATPEFHGPAGRDTFVGAGDDFHPNDAGHRAIADAVLAVLAH
>NC_015125.1|WP_013585453.1|2567783_2568191_+|NAD(+)--rifampin-ADP-ribosyltransferase
MSEILDAGPFFHGTKAALRVGDLLTPGFPSNYRPEILMNHVYFTSRLDGAGLAAEIIPGDGPPRVYEVEPTGEFEDDPNVTDKKFPGNPTRSFRSAAPLRIVAERDDWTRLTPEALETWRRRLTEMRDENAEIIN
>NC_015125.1|WP_167539374.1|2568200_2568341_-|hypothetical-protein
MRQRTPDPRRCPTCGDPLSFEILDDERFLVAWSCVNCGLIRTTEPV

Crispr_ID: NC_015125_13

• CRISPR_ID: NC_015125_13
• CRISPR_location: 2619054-2619148
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_13

Consensus_repeat	Method
AGGACCCTGAGCTCGTCGAAGGGT	CRISPRCasFinder

spacers of NC_015125_13

>13.1|2619078|47|NC_015125|CRISPRCasFinder
TCGGTGGCTTCGACGTGCTCAGCCACCTCCGCCGTCGCCCTCGGGGG

CRISPR arrays and Neighbor proteins around NC_015125_13

CRISPR arrays

The CRISPR arrays of NC_015125_13

>merge|NC_015125|13|2619054-2619148|CRISPRCasFinder
AGGACCCTGAGCTCGTCGAAGGGTTCGGTGGCTTCGACGTGCTCAGCCACCTCCGCCGTCGCCCTCGGGGGAGGACCCTGAGCCCGTCGAAGGGT

>NC_015125|13|12|2619054-2619148|CRISPRCasFinder
AGGACCCTGAGCTCGTCGAAGGGT	TCGGTGGCTTCGACGTGCTCAGCCACCTCCGCCGTCGCCCTCGGGGG
AGGACCCTGAGCCCGTCGAAGGGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_050901866.1|2626427_2627498_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|273670
NC_015125.1|WP_013585502.1|2613770_2614931_+|cystathionine-gamma-synthase	unknown	unknown	gnl|CDD|236104
NC_015125.1|WP_013585499.1|2611361_2611682_+|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013585507.1|2617880_2619017_+|UDP-N-acetylmuramate-dehydrogenase	unknown	unknown	gnl|CDD|237552
NC_015125.1|WP_013585511.1|2622272_2622851_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|379324
NC_015125.1|WP_013585500.1|2611753_2612602_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187578
NC_015125.1|WP_013585501.1|2612769_2613774_+|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|273464
NC_015125.1|WP_013585503.1|2615150_2615786_-|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl|CDD|224996
NC_015125.1|WP_013585498.1|2610801_2611365_+|aspartate/tyrosine/aromatic-aminotransferase	unknown	unknown	unknown
NC_015125.1|WP_013585512.1|2622905_2624198_-|MFS-transporter	unknown	unknown	gnl|CDD|340877
NC_015125.1|WP_013585515.1|2625826_2626435_+|nicotinamide-mononucleotide-transporter	unknown	unknown	gnl|CDD|377432
NC_015125.1|WP_013585508.1|2619230_2620430_-|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|235596
NC_015125.1|WP_013585514.1|2624978_2625770_+|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl|CDD|224268
NC_015125.1|WP_013585505.1|2617030_2617480_+|MaoC-family-dehydratase	unknown	unknown	gnl|CDD|379194
NC_015125.1|WP_013585517.1|2627507_2629079_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|223786
NC_015125.1|WP_013585504.1|2616084_2616891_+|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl|CDD|376667
NC_015125.1|WP_013585506.1|2617476_2617881_+|MaoC-family-dehydratase-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|239537
NC_015125.1|WP_013585513.1|2624252_2624903_-|ketohydroxyglutarate-aldolase	unknown	unknown	gnl|CDD|180618
NC_015125.1|WP_043361378.1|2620885_2622181_+|chloride-channel-protein	unknown	unknown	gnl|CDD|238505
NC_015125.1|WP_013585509.1|2620470_2620794_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_050901866.1|2626427_2627498_+|AAA-family-ATPase	gnl|CDD|273670	TIGR01526, nadR_NMN_Atrans, nicotinamide-nucleotide adenylyltransferase, NadR type. The NadR protein of E. coli and closely related bacteria is both enzyme and regulatory protein. The first 60 or so amino acids, N-terminal to the region covered by this model, is a DNA-binding helix-turn-helix domain (pfam01381) responsible for repressing the nadAB genes of NAD de novo biosynthesis. The NadR homologs in Mycobacterium tuberculosis, Haemophilus influenzae, and others appear to lack the repressor domain. NadR has recently been shown to act as an enzyme of the salvage pathway of NAD biosynthesis, nicotinamide-nucleotide adenylyltransferase; members of this family are presumed to share this activity. E. coli NadR has also been found to regulate the import of its substrate, nicotinamide ribonucleotide, but it is not known if the other members of this model share that activity.	1.08739e-52
NC_015125.1|WP_013585502.1|2613770_2614931_+|cystathionine-gamma-synthase	gnl|CDD|236104	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional.	0
NC_015125.1|WP_013585507.1|2617880_2619017_+|UDP-N-acetylmuramate-dehydrogenase	gnl|CDD|237552	PRK13903, murB, UDP-N-acetylmuramate dehydrogenase.	2.88035e-141
NC_015125.1|WP_013585506.1|2617476_2617881_+|MaoC-family-dehydratase-N-terminal-domain-containing-protein	gnl|CDD|239537	cd03453, SAV4209_like, SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.	1.12581e-44
NC_015125.1|WP_013585500.1|2611753_2612602_+|SDR-family-oxidoreductase	gnl|CDD|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.73681e-88
NC_015125.1|WP_013585501.1|2612769_2613774_+|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|273464	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase. Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family].	1.46455e-166
NC_015125.1|WP_013585503.1|2615150_2615786_-|NAD(P)-binding-domain-containing-protein	gnl|CDD|224996	COG2085, COG2085, Predicted dinucleotide-binding enzymes [General function prediction only].	1.35963e-43
NC_015125.1|WP_013585512.1|2622905_2624198_-|MFS-transporter	gnl|CDD|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.94913e-97
NC_015125.1|WP_013585515.1|2625826_2626435_+|nicotinamide-mononucleotide-transporter	gnl|CDD|377432	pfam04973, NMN_transporter, Nicotinamide mononucleotide transporter. Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.	7.04365e-47
NC_015125.1|WP_013585508.1|2619230_2620430_-|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NC_015125.1|WP_013585514.1|2624978_2625770_+|DeoR/GlpR-transcriptional-regulator	gnl|CDD|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.94561e-76
NC_015125.1|WP_013585505.1|2617030_2617480_+|MaoC-family-dehydratase	gnl|CDD|379194	pfam13452, MaoC_dehydrat_N, N-terminal half of MaoC dehydratase. It is clear from the structures of bacterial members of MaoC dehydratase, pfam01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerize to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.	3.55853e-32
NC_015125.1|WP_013585517.1|2627507_2629079_+|AAA-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	5.05254e-13
NC_015125.1|WP_013585504.1|2616084_2616891_+|sulfite-exporter-TauE/SafE-family-protein	gnl|CDD|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	2.95112e-25
NC_015125.1|WP_013585511.1|2622272_2622851_-|AAA-family-ATPase	gnl|CDD|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	6.18817e-11
NC_015125.1|WP_013585513.1|2624252_2624903_-|ketohydroxyglutarate-aldolase	gnl|CDD|180618	PRK06552, PRK06552, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	3.99527e-68
NC_015125.1|WP_043361378.1|2620885_2622181_+|chloride-channel-protein	gnl|CDD|238505	cd01033, ClC_like, Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent gating mechanism. This superfamily lacks any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. The voltage-dependent gating is conferred by the permeating anion itself, acting as the gating charge.	1.28226e-102

Protein sequences

>NC_015125.1|WP_013585507.1|2617880_2619017_+|UDP-N-acetylmuramate-dehydrogenase
MPEVAPIPLSQLTTLRTGGEPARLIEAHTADELIAALREVWAEGDDWFVLGGGSNLFVGDEPFEGTVIRVRTAGIEELPGSRPDTVRLRVQAGHDWDALVAETVERGLAGIEAMSGIPGTVGAAPVQNVGAYGQEIVQTLVEVELIDESTGDVSVVPAADLGLGFRTSVLKQHYGSIPDRSAVILSVTLELERVGPGERPIAGEQLRGALGLDADDAVSLRWIRDHVLATRARKGMVLDPEDPDTWSAGSFFQNAIVSAAFARTLPEACPKWPMAPILDPVTVIPLAAFDGILPPPPVERHEVKVSAAWLIENAGLRRGFRFPRSRAGLSTKHTLALTNRGEATAAEIAELARFVQNRVHSEFGLVLQPEPVLVNVEL
>NC_015125.1|WP_013585506.1|2617476_2617881_+|MaoC-family-dehydratase-N-terminal-domain-containing-protein
MSEFTVGEVIAERSVHLTRESLVRYAGASGDFNPIHYRDDVAAAVGLPGVLAHGMLTMGIAVGTLADAIGDPGRIAEYGVRFTRPVVVDPETGADLHVSAKVGAVDDETARIDLTVTFAETTVLGKAQVRVRLR
>NC_015125.1|WP_013585505.1|2617030_2617480_+|MaoC-family-dehydratase
MPVNPELVGRVFPPTAPYLVGREKVREFARAVFADAPQHSDPEAARALGYADVVAPPTFAMVVQDLTLQQLLGDPDSGIELSRLVHAEQRFRYTRPIVAGDELVATLSVTGIRSMGGNAMITSEAEIVDATGAHVVTTTSILLAGEAGA
>NC_015125.1|WP_013585504.1|2616084_2616891_+|sulfite-exporter-TauE/SafE-family-protein
MSFVHADTRPPRSVRFFAVCIGVGLLAGLMSGLFGVGGGTVIVPLLVLLLGFDQRFAAGTSLAAIVPTATVGVITYAVDGHVAWIPALILAAGAVLGAQIGTWLLPKLSQTALRWAFVAFLLAVIVSLYFVIPSRDAELVLTWVTGPGLALLGVVTGILAGLLGVGGGIIVVPALLLLFGTSDLIAKGTSLLMMIPTAISGTVGNLRRSNVDLTAAACVGLAACATTALGAQIAKAVDPFVANVLFSIFLVFIASQIAIKAVRGRHQR
>NC_015125.1|WP_013585503.1|2615150_2615786_-|NAD(P)-binding-domain-containing-protein
MTTVGIIGAGHIGSALAKGFAQHGYDVVIANSRGPETLSDLVAEVGEKARAATAQDAAEAGDFVVVTVPLKAYKAVPVAPLVGKIVLDTNNYYFERDGHIAELDEKQTTTSQMLQEHLPESHVAKAFNHIMASDILTDGAPAGTENRRALATSSDSDEAVALVTRIYDEFGFDTVNIGPLSESWRVERDQPAYVVRQNAAELEQNLARAER
>NC_015125.1|WP_013585502.1|2613770_2614931_+|cystathionine-gamma-synthase
MSTHDAARGFDSLAVHAGQAPDEATGAVIPPIHVSTTYAQDGIGGLRGGYEYGRSGNPTRTALETQIAALEGGVRALSFASGLAGEDALLRAALVPGDEVLLGNDVYGGTYRLLARVLGPWGVRLRVVDMSDLDAVAAAIEERAPRMVWVETPSNPMLRITDIAGLARLGHAAGSIVVVDNTFASPALQRPISLGADVVVHSATKYLGGHSDVVGGALAFADAELAEKTQFLQFAAGAVSGPFDAYLTTRGIKTLAVRMQRHSSNAQAVAEHLASHDRVARVYYPGLPQHPGHELAARQMSGFGGIVSLELADGATARRFAESTRLFTLAESLGGVESLVNYPDAMTHASVRGTELAVPDTIVRLSVGIESVDDLVADVDQALASL
>NC_015125.1|WP_013585501.1|2612769_2613774_+|pyridoxal-phosphate-dependent-enzyme
MRYAQSVADLVGNTPLVRLSRVTDGIAATVLAKIEYINPGGSAKDRIAANIIDAAERDGHLKPGGVIVEPTSGNTGVGLALVAQQRGYRCVFVVPDKVAEDKRAVLRAYGAEVVVTPTNVEPDDPNSYYSVSDRLVREIPGAFKPNQYANPNGPRSHYETTGPEIWRDTDGRLTHFVAGVGTGGTISGTGRYLREVAGSAVRIVGVDPVGSIYSGGDIHGYDVEGVGEDFWPPAFDPTVVDAYERVSDAESFAMTRRLAREEGLLVGGSSGMAVVGALRVARDLPADAVMVVVLPDHGRGYLSKIFDDDWMRAHGYDVEPTASLIPTPSEEHSA
>NC_015125.1|WP_013585500.1|2611753_2612602_+|SDR-family-oxidoreductase
MSTPPVIAVTGSTGAVGGRVARDLAARGIPQRLLVRDASRAPVLEGAEVHVARYSDADAARTALQGVETLFMVSASETADRVEHHRTFVEAAAAAGVRSIVYTSFLAAAPDAVFTLGRDHAATEEIIRASGMRWTFLRDNFYMDMMELFAGDDGVIRGPAGEGRCSLVSRSDVAATAVSVLLDPSAHADTAYDLTGPEALTMAEVAQKISAVRGHPVRFLDETVDEAYASRAAFGAPRWQVDAWVSTYTAIASGDLAGVSGDVERVTGRPAQSFEEFLGAVA
>NC_015125.1|WP_013585499.1|2611361_2611682_+|hypothetical-protein
MTDITAAALAPRIDLAVTATEGVREMYSARPVVARALEHVVDVEGSLAAVDDADGARSITVCIGVSTQDDSVAVASAVAAAVRGTDETALPATVRVRVARLVAPAS
>NC_015125.1|WP_013585498.1|2610801_2611365_+|aspartate/tyrosine/aromatic-aminotransferase
MSDDIGASGYSLEDLSAYLDRGRVPRIAAIERNAECQAVLASMERMGRLSREIVEEQAAEPLAESWYDSIMREVMREFRAGRDIPLVRGADGVEIVVTEGALYELIRAVGDGVDGVLVGRVRLHQPEPDAPLDVRVSVSVRFGRAMTPAVDEMREGIREAIERHGDLRVGKVDVTVGDVHFDGEEDE
>NC_015125.1|WP_013585508.1|2619230_2620430_-|pyridoxal-phosphate-dependent-aminotransferase
MTSRAPLSRKLSAIAESATLKVDAKAKALQAAGRPVISYAAGEPDFATPSFIVDAAAEALQDPKNYRYTPAAGLPVLREAIAAKTLRDSGLEVAPSQVIVTNGGKQSVYQAFQTVVNPGDEVLLPAPYWTTYPEAIALADGTPVEVFAGADQDYKVTVAQLEAARTDKTTVLVFVSPSNPTGSVYTPEETAEIGRWALEHGIWVITDEIYQNLTYEGVRAVSIVEAVPELAEQTILVNGVAKTYAMTGWRVGWMVGPADAMKLAGNLQSHLSSNVNNVAQIAAAAALNGPQDEAEQFRLAFDRRRQLIVSELAKIDGVEVPNPLGAFYVYPDVRGLLNRSWDGVTPTTSLELADLILEKAEVAVVPGEAFGPSGYLRLSYALGDDQLLEGVQRLQRLFA
>NC_015125.1|WP_013585509.1|2620470_2620794_-|hypothetical-protein
MTPPPASPRRPADVFGIVAVVLAAVVLLPTLFVFLVGLIPEMNAIWWLGIILLPFLLLGGVIVVVLAVIGIVVAIRRGGRRAWSITAVGLGILMLVPPGYVWFSSLS
>NC_015125.1|WP_043361378.1|2620885_2622181_+|chloride-channel-protein
MTAEPLAPTRPHRRAVLALSKLGLATLIVGLATGVAVLLLVWIVHSIEHLVWGHEQGPFLDGLPLPSPWWLPIATVGGAGVIAALGWYLLRRFGRTLATVEQGVDGKRMPWWETLADTVIQVTSVALGASIGKEVAPRELSAMAGSKIVGWFGLDARWRRILIASAAGAGLAAVYNVPLAGALFAIEILLAQFSVGAAVVALSVSAIATFVARPLVGDGSLYQVPALEVNASLVVAALLIGPLMGWGATSFATVTKALGRFRPKGWKLLVVLPLTFAAVGVLGAFFPLILGNGRALATAGFDLSQPALLLLLLALLKYVATTISLGSGAIGGTLQPSVAVGAALGAAAAAGWALIWPGADGTALAIIAAAAFLASNMRAPFTAIALIIEFTDTGFTLLLPIFLAVAGSLAASRLSSRAGLRRFTPIDPARP
>NC_015125.1|WP_013585511.1|2622272_2622851_-|AAA-family-ATPase
MTARLFFVIGPAGSGKSTVSTLIARRIRAAYLDKDSVATAFTEALLEAAGSDKNERDNNPYYQSVVMGLEYATLLRLAGDNLRLGNDVVLDAPFVRYFPEEDYLERAAASHGWPADVVITVVHVTVDGALVRDRVDSRGYGRDAWKLAHWDEFWATAQAADCRWRGAHHVLFDNSAPGADPAALEAALAAFV
>NC_015125.1|WP_013585512.1|2622905_2624198_-|MFS-transporter
MSETTADAPVLTRDEKKTIRIRWFLVGFLILGGVVNYLDRSTLSVANTTIAGEFGLDPLAMGLLLSAFSWPYAIANLPAGYLVDKFGPKKMFAFAAGAWSLVSIVTAAANSFGVLYACRVALGITESPFFTSALKVNERWFNKSERALPVSLVNTGSQIANAIAPPLLTFLLLTMSWRGMFIIVGAFGIVVALVWLRIYRDPTLKEQALIKGAEAEARVAASVEKVGWGRLLLQSNTWFMVLGAFGIFYTVWVYLTWLPSYLQTARGFSLAQSGWLASLPFLCGIIGVIFGGWLSNRLVRRGVNTVRARKIPIVGGAVLAAAAVLPVAYVDSTPLAIVLLSVGYFASQVPIGCLWTLASDVAPSNQVASLGAIQNFGGFIGAAVAPVVTGAILASTGGNYTTVFLIGGVLLLVGALSYGLFVKDRSVAAS
>NC_015125.1|WP_013585513.1|2624252_2624903_-|ketohydroxyglutarate-aldolase
MLKKHEVLSSVIDTGVVLIVRLDSPDEALAVSRAAVAGGIRALEITLSVPRALEVVRTLADEFGDHVAVGVGTVLDAEMAVASVQAGARMLVSPNLNPDMIRAANRYQAVTISGAFTPTEIVATMEAGADIVKLFPTEIAGPDYLRTVMAPLAHAPILPAGGATRDNVGDWFGAGALAVGVGSAITKAARPTGDMADVTRAAADFLAAVASARTPH
>NC_015125.1|WP_013585514.1|2624978_2625770_+|DeoR/GlpR-transcriptional-regulator
MSTPPPLIPEQRQRELMRLLRGAGALSIRHLASSLGVSHMTVRRDIAALEDEGLVDAVQGGVRLRERTGVEPPRERGSRAVLELPRKEAVARRAAALIADDMTVFIDAGTTCQALVPHLTARRGLTVVTNDFFTVSALYAHPAIEVIHTGGVVDAASGSSSGALAAATVSAMTLDLAILSTGTWDTAHGLTTPELDKVVLKRAVLDAATSGALVADSTKYGTAERFRVVPLDALDVIVSDAELPESAAAAIAEMGVELWTAEE
>NC_015125.1|WP_013585515.1|2625826_2626435_+|nicotinamide-mononucleotide-transporter
MIEWILAEWTQILGFATGAACVMLAARRNVWTYPIGIANNLVFLVVFVPAGLYASAALQVVYLVLGVHGWLRWTRGVEHDREYVARTPRCAVPWLIVAAVAGTALLTWVLATFTDSQVALADAATTSASLVAQYMLNRKWIENWFVWIGVDIAFVALSIATGLWIIAALYALFIVLCVSGLWSWRRVQNEARDAEPAADARA
>NC_015125.1|WP_050901866.1|2626427_2627498_+|AAA-family-ATPase
MPERRYRHGVVVGKFYPLHVGHAHLIRSAVRACERVTVEVIAASVESIALEKRAAWVREDHPTVRVVDLLDDTPVDFASETAWDAHTATIAGLLDEPVDVVFTSDEYGAELARRLGADWVQVDPGRRINPVSGTAIRADLDAHWHELSPAVRAGLTARVVVLGAESTGSTTLAEALAAELGTLWVPEYGRELSETREGGLEAPWRSDEFDLVVDRQIAWEQDAARRAPRPVLICDTDVLATALWHERYVGTPAPRILERAAAHRPVLYLLTGDEIPFVQDGMRDGEHIRADMQERFREVLAGQSVPWFEVRGSVAERVASALPAIRRAVAEATSFAAPMEGRPPAEQEELRRRADG
>NC_015125.1|WP_013585517.1|2627507_2629079_+|AAA-family-ATPase
MADRWHKLSQAPTTSASGEGTAPMTAADLFRDTAETVVVPLDEKLRQTYYWIVNRAVISPYYDVEFSSGAPLAFTLGDAGAELTLPSEASFSSNVLLPLLSFAVGGKCLLVGGPGRGKTTVAVLMGVLAGSTPDDVRRGVQQGQPQLTISDLVGIPLPRDLMNAASLAEVGVAWRDWLSRPVKIVDEYNRIPTKTQSALLTMVAEGYVESHDQLRKTAPASGVESWFFTANDDAGGGTFPVIQALRDRMDVTVPAAGFNSRFLDELITRVEAGEKPEEHVPAELVFAPDEQTAMRAAIRAVPVPADVRRRLEFFLSHFEFVQGGGRRFEYRTKDTVTTAGGKVAETIEANSGADLMADLGAQTLNGLSVRALQTLIVYAKAVAWFRGRDAVSLADVAAMVPFVLRGKLLPNPTHPRFDVGVERELSTDLMSWLSDLFAESCRQYDALGRGRKDPVGELLAQLDAGLDGVSAVEASRRLTAIEARLRAASASGKLYGRDFDDLTALKYLHQRYTAYLRWVEGRA

Crispr_ID: NC_015125_14

• CRISPR_ID: NC_015125_14
• CRISPR_location: 3014991-3015119
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_14

Consensus_repeat	Method
GGGTCCCGGGGGCTTCGACGGGCTCAGCCACCTCGGCGGGGGAGG	CRISPRCasFinder

spacers of NC_015125_14

>14.1|3015036|39|NC_015125|CRISPRCasFinder
CCCCTGAGGGTGTCGAAGGGACCGAGGCTCTCGTGGGTC

CRISPR arrays and Neighbor proteins around NC_015125_14

CRISPR arrays

The CRISPR arrays of NC_015125_14

>merge|NC_015125|14|3014991-3015119|CRISPRCasFinder
GGGTCCCGGGGGCTTCGACGGGCTCAGCCACCTCGGCGGGGGAGGCCCCTGAGGGTGTCGAAGGGACCGAGGCTCTCGTGGGTCGGGTCCCGGGGGCTTCGACGGGCTCAGCCACCTCTGCGGGGGAGG

>NC_015125|14|13|3014991-3015119|CRISPRCasFinder
GGGTCCCGGGGGCTTCGACGGGCTCAGCCACCTCGGCGGGGGAGG	CCCCTGAGGGTGTCGAAGGGACCGAGGCTCTCGTGGGTC
GGGTCCCGGGGGCTTCGACGGGCTCAGCCACCTCTGCGGGGGAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013585861.1|3002081_3002579_+|HNH-endonuclease	unknown	unknown	gnl|CDD|224321
NC_015125.1|WP_013585880.1|3024017_3024497_+|phenylacetate-CoA-oxygenase-subunit-PaaJ	unknown	unknown	gnl|CDD|131214
NC_015125.1|WP_043362980.1|3015918_3016779_+|3-hydroxyacyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|224170
NC_015125.1|WP_013585876.1|3020956_3021619_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|223620
NC_015125.1|WP_013585862.1|3002650_3003208_+|cysteine-hydrolase	unknown	unknown	gnl|CDD|238496
NC_015125.1|WP_050901876.1|3011776_3012511_+|NRDE-family-protein	unknown	unknown	gnl|CDD|377554
NC_015125.1|WP_013585874.1|3018826_3019519_+|hydroxyphenylacetyl-CoA-thioesterase-PaaI	unknown	unknown	gnl|CDD|131339
NC_015125.1|WP_158309757.1|3012637_3013501_+|DUF4436-family-protein	unknown	unknown	gnl|CDD|379624
NC_015125.1|WP_013585864.1|3004032_3005577_+|DNA-polymerase-Y-family-protein	unknown	unknown	gnl|CDD|176458
NC_015125.1|WP_013585879.1|3023187_3024024_+|phenylacetate-CoA-oxygenase-subunit-PaaC	unknown	unknown	gnl|CDD|368300
NC_015125.1|WP_013585866.1|3009090_3010272_+|DUF2510-domain-containing-protein	unknown	unknown	gnl|CDD|236090
NC_015125.1|WP_013585870.1|3013791_3014982_+|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl|CDD|238383
NC_015125.1|WP_013585865.1|3005619_3009033_+|error-prone-DNA-polymerase	unknown	unknown	gnl|CDD|235553
NC_015125.1|WP_013585878.1|3022681_3022987_+|1,2-phenylacetyl-CoA-epoxidase-subunit-B	unknown	unknown	gnl|CDD|237504
NC_015125.1|WP_013585877.1|3021722_3022682_+|1,2-phenylacetyl-CoA-epoxidase-subunit-A	unknown	unknown	gnl|CDD|184320
NC_015125.1|WP_148272885.1|3016775_3018830_+|phenylacetic-acid-degradation-bifunctional-protein-PaaZ	unknown	unknown	gnl|CDD|236931
NC_015125.1|WP_013585867.1|3010291_3011494_-|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	unknown	unknown	gnl|CDD|235513
NC_015125.1|WP_013585881.1|3024496_3025636_+|phenylacetate-CoA-oxygenase/reductase-subunit-PaaK	unknown	unknown	gnl|CDD|131215
NC_015125.1|WP_099046956.1|3001040_3001736_+|M23-family-metallopeptidase	unknown	unknown	gnl|CDD|366703
NC_015125.1|WP_013585875.1|3019515_3020826_+|phenylacetate--CoA-ligase	unknown	unknown	gnl|CDD|131210

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013585861.1|3002081_3002579_+|HNH-endonuclease	gnl|CDD|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	9.91941e-23
NC_015125.1|WP_013585880.1|3024017_3024497_+|phenylacetate-CoA-oxygenase-subunit-PaaJ	gnl|CDD|131214	TIGR02159, Putative_12-phenylacetyl-CoA_epoxidase_subunit_D, phenylacetate-CoA oxygenase, PaaJ subunit. Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other].	4.57323e-61
NC_015125.1|WP_043362980.1|3015918_3016779_+|3-hydroxyacyl-CoA-dehydrogenase-family-protein	gnl|CDD|224170	COG1250, FadB, 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism].	5.41556e-96
NC_015125.1|WP_013585876.1|3020956_3021619_-|HAD-family-hydrolase	gnl|CDD|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	1.93616e-31
NC_015125.1|WP_013585862.1|3002650_3003208_+|cysteine-hydrolase	gnl|CDD|238496	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.	5.28558e-53
NC_015125.1|WP_050901876.1|3011776_3012511_+|NRDE-family-protein	gnl|CDD|377554	pfam05742, TANGO2, Transport and Golgi organisation 2. In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation. In plants this family includes Solanum habrochaites Cwp, which is involved in water permeability in the cuticles of fruit. Mouse Tango2 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.	4.02546e-15
NC_015125.1|WP_013585874.1|3018826_3019519_+|hydroxyphenylacetyl-CoA-thioesterase-PaaI	gnl|CDD|131339	TIGR02286, Acyl-coenzyme_A_thioesterase_PaaI, phenylacetic acid degradation protein PaaD. This member of the domain family TIGR00369 (which is, in turn, a member of the pfam03061 thioesterase superfamily) is nearly always found adjacent to other genes of the phenylacetic acid degradation pathway. Its function is currently unknown, but a role as a thioesterase is not inconsistent with the proposed overall pathway. Sequences scoring between trusted and noise include those from archaea and other species not known to catabolize phenylacetic acid and which are not adjacent to other genes potentially involved with such a pathway.	8.06863e-37
NC_015125.1|WP_158309757.1|3012637_3013501_+|DUF4436-family-protein	gnl|CDD|379624	pfam14494, DUF4436, Domain of unknown function (DUF4436). This is a family of membrane and transmembrane proteins from mycobacterial and related species. The function is not known.	2.36037e-91
NC_015125.1|WP_013585864.1|3004032_3005577_+|DNA-polymerase-Y-family-protein	gnl|CDD|176458	cd03468, PolY_like, DNA Polymerase Y-family. Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.	1.42115e-45
NC_015125.1|WP_013585879.1|3023187_3024024_+|phenylacetate-CoA-oxygenase-subunit-PaaC	gnl|CDD|368300	pfam05138, PaaA_PaaC, Phenylacetic acid catabolic protein. This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid. These proteins may form part of a dioxygenase complex.	1.66399e-89
NC_015125.1|WP_013585866.1|3009090_3010272_+|DUF2510-domain-containing-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	6.93805e-16
NC_015125.1|WP_013585870.1|3013791_3014982_+|acetyl-CoA-C-acyltransferase	gnl|CDD|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.36189e-179
NC_015125.1|WP_013585865.1|3005619_3009033_+|error-prone-DNA-polymerase	gnl|CDD|235553	PRK05672, dnaE2, error-prone DNA polymerase; Validated.	0
NC_015125.1|WP_013585878.1|3022681_3022987_+|1,2-phenylacetyl-CoA-epoxidase-subunit-B	gnl|CDD|237504	PRK13781, paaB, phenylacetate-CoA oxygenase subunit PaaB; Provisional.	1.0126e-55
NC_015125.1|WP_013585877.1|3021722_3022682_+|1,2-phenylacetyl-CoA-epoxidase-subunit-A	gnl|CDD|184320	PRK13778, paaA, phenylacetate-CoA oxygenase subunit PaaA; Provisional.	0
NC_015125.1|WP_148272885.1|3016775_3018830_+|phenylacetic-acid-degradation-bifunctional-protein-PaaZ	gnl|CDD|236931	PRK11563, PRK11563, bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional.	0
NC_015125.1|WP_013585867.1|3010291_3011494_-|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	gnl|CDD|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	0
NC_015125.1|WP_013585881.1|3024496_3025636_+|phenylacetate-CoA-oxygenase/reductase-subunit-PaaK	gnl|CDD|131215	TIGR02160, 12-phenylacetyl-CoA_epoxidase_subunit_E, phenylacetate-CoA oxygenase/reductase, PaaK subunit. Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other].	1.0208e-154
NC_015125.1|WP_099046956.1|3001040_3001736_+|M23-family-metallopeptidase	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.5501e-33
NC_015125.1|WP_013585875.1|3019515_3020826_+|phenylacetate--CoA-ligase	gnl|CDD|131210	TIGR02155, Phenylacetate-coenzyme_A_ligase, phenylacetate-CoA ligase. Phenylacetate-CoA ligase (PA-CoA ligase) catalyzes the first step in aromatic catabolism of phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Often located in a conserved gene cluster with enzymes involved in phenylacetic acid activation (paaG/H/I/J), phenylacetate-CoA ligase has been found among the proteobacteria as well as in gram positive prokaryotes. In the B-subclass proteobacterium Azoarcus evansii, phenylacetate-CoA ligase has been shown to be induced under aerobic and anaerobic growth conditions. It remains unclear however, whether this induction is due to the same enzyme or to another isoenzyme restricted to specific anaerobic growth conditions. [Energy metabolism, Other].	0

Protein sequences

>NC_015125.1|WP_013585870.1|3013791_3014982_+|acetyl-CoA-C-acyltransferase
MSQAFLIGGARTPVGRYGGALASVRPDDLAALVVGEAVARAGVPAEAIDEVILGAANQAGEDNRNVARMAVLLAGLPDAIPGLTVNRLCASGMSAIALAAQAVRAGDADIVVAGGVESMTRAPWVQAKPAKAWAKPGEAFDTSIGWRFTNPRLAARDRATFTMPETAEEVARVDGISRADADAFALRSHERAIRAQDAGHFRDEIVGVETPRGLVDTDEGPRRDTSLEVLAGLRPVVKGGEVVTAGNASSLNDGASAIVVASAAAVERYGLRARARIVAHASAGVAPEVMGLGPVPATEKALAKARLSASDLGAVELNEAFASQSLACMRRLGLDPEIVNADGGAIALGHPLGSSGSRLLVTLLGRLEREEARYGLATMCVGVGQGTAMIVERVDG
>NC_015125.1|WP_158309757.1|3012637_3013501_+|DUF4436-family-protein
MSSTARPGHRTAVGVGGIVVAIIALYVTVVVLYASGSGVVSRGDDEVSPGAVSLVLTPEKMDAATSRLTVSLLPKQADGGEYTNGVTIDKPFAVLVSAVAGSTAVHYQPSELVAPTEVSFVMDGAIEQWPFDRYHVTSFVVAAVDDADGESVPLPTAVTVSGRGVTGWDITMAERDAGDGLLAVDISASRSGATVAFGIVLLTLMVIIPTLVLIVAIAVLRGRRKVEVTTLGWMGAMVFATIPLRNFLPGSPPIGSWIDYLIVLWVIAALVAGLVIFVIAWWRRGPA
>NC_015125.1|WP_050901876.1|3011776_3012511_+|NRDE-family-protein
MCTVVIDVPAAPSDPVRLLAVRDEDRDRPWRGVGPWWPDRSGVLGVRDDRAGGAWLAVDPDRRRLAVLLNREDLSTRGDDEVVSRGAIALDALGDGIPDQPPTRGFNLVDVDATGAHLVEWDGRESRRTRLSPGTHMVAHHAVDDPGTPRIARWLEEFRRAGLGEGSGWWEPWMNVVERATRDPGSSVLRRDAHDGLVLESLLICAASIGPDGVEVREARLAEPGHWDAGLPTRLLSGDPLSRR
>NC_015125.1|WP_013585867.1|3010291_3011494_-|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC
MFIVVGVTGGIAAYKTVGLVRLLVKAGHDVHVIPTDDALRFVGSPTWEAISRNPVTTSVHDDVARVRHVALGQAADLVIIAPATANTLAAMTAGLASDLLGTTLLATTAPVVVAPAMHTEMWRHPATAHNMQVLRSRGVHVVGPADGALTGGDSGPGRMSEPEDIVAAALALVERPRDLEGVSVVVSAGGTREPIDPVRFLGNRSSGRQGVAIARAAADRGARVTLVAAHLDADVVPDPRVEVIAVATAEELGRAMDATAPDADVIVMAAAVADYSVASVSEHKLRKQDTPGGFTLELVENRDIVAGLVAARRDGQTIVAFAAETVRDDDELLERARAKAARKGVDLLAANAVGWTRGFESVDNELVIIGRDGEIVATASGSKDDTAHSLLDAVLTAQGR
>NC_015125.1|WP_013585866.1|3009090_3010272_+|DUF2510-domain-containing-protein
MTDTPTPPDGWYPDPAGSGGTRRWDGIAWTDEVRPAGEEQRDAGPVETSNAGVTAHPAAGESPDGVADPASAPGAAAPASGAEAVSAPASASVPASDAAPIPAAVPASGAEAAPAPAEAAPAPEAAPAPAAAPAPVAAAAAPAPAPAPAYGAAPVSAPAPAAAPAYGATPVSAPASPSTPATPPGYPAYSTAPGYTGASAPAYGGGAPGYTAPGAQAATPANPGVPTDTVWVWLIVALPLVQLLVLFLFDWRALIEQSLATAFLSAQGGTTSSVVGLSLQSTFLSLGVGLVSLVISGLSVLFAFLDWRQLRARGIQKPFHWAWAFFAFVVSAGVYVIGRGIVLRRQTGKGLGPIWGFIGVSVVSIIAAAIWAILLLRDFSALFEQYMYYYYGY
>NC_015125.1|WP_013585865.1|3005619_3009033_+|error-prone-DNA-polymerase
MGWANPPVKWSELERLLSDARRPTGAPPNGDGGDSPAWSHKRGAYVPPAIERPADTVPYAELHAHSSYSFLDGASSPEELVEEAERLGLHALAVTDHDGFYGIVRFAEAAEARAVQTVFGAELSLELPAPQKGEADPAGSHLLVLARGEEGYHRLAAAITHAQLTGAEKGRPVYDLAELSERSGGPADPHWAVLTGCRKGAVRQALASAGPEAAARELDALVDLFGAEAVFVELMDQGNPLDSRHNDVLAGLAAERGLPILATNNVHYAVPEKELLAAAVAAVRANRGLDELDGWLPAHAGAHLRSGAEMAARFARYPGAVARTVTLADELAFPLRRAKPALPKQDVPEGHTPMSWLRHLVWEAVPRKYPNLSDEDRDRIERELGVIEMKDFPGYFLIVYGIVAEARRRGILCQGRGSAANSAVCFLLEITAVDSIFYKLPFERFLSSLRDEEPDIDVDFDSDRREEIIQWVYETYGRERAAQVANVIQYRPKNAVRDMARALGHSPGQQDAWSKQVERWGATLETGADHDIPDQVIEFAAELLKAPRHLGIHSGGMVLTDRPVGEVVPIEHARMENRTVIQWDKDDAAWMGLVKFDLLGLGMLAALQYCFDLIRDATGEAWELSTLPKEEKAVYDMLCRADSIGVFQVESRAQMGLLPRLQPRKFYDLVVQIALIRPGPIQGGAVHPFVRRKLGQEEITYVHPKLKPVLERTMGVPVFQEQLMQMAVAVGNCTAEDADQLRRAMGSKRGLERIDSLREKLYEGMAENGLVGHVADELYAKIQAFANFGFAESHSLSFALLVYASSWIKLHYPAAFLAGLLRAQPMGFYSPATLTADARRHGVRVRRPDLLRSGVEAGMEPLDDAGERGPTGLDACAEAHQPPTGEFDRSEPDETAAHRRDGAFAVRLGLAGVTGIGTNVAERIVSERERGGAYRDMRDLVRRTGLITAQLEALATAGAFESLGHSRREAIWLSGSAALDRPEFLPDSLVAVQPPLFTDPTSYELLASDLWATGLSADDHPLTHFRSALDARGVLTSRELQTAETDRRIEVAGLVTHRQRPATASGITFLNLEDEHGLMNIICSVGVWNRYRRIARESPALIVRGMLERSVEGVTNVVADGFTDLRVGVSHASRDFR
>NC_015125.1|WP_013585864.1|3004032_3005577_+|DNA-polymerase-Y-family-protein
MQAPTRSLVLWFPDWPITAFVHEASSPPRDDAPVAVFAHNVVVACSAAARVQGVRRGQRRRDAQALCPALMVIAADPVRDARVFGPVVARIEDRAPGVQVVRPGLCALRARGPARYYGGEAEAARTLVDLLAAEGFFGVRASVADGIFTAGHAARAASSEEPVRVVPPGEAAPFLAPLSVAALDDEEMASLLARLGVHTLGAFAAMPVERVQERFGPRGVRLHSLAGGRDSQPVEPRTPPPELHRDVAFEPPLDLADQVAFGMRVAAEEFIAHLGAQNLVCTELRVVLSGERGERSERVWLHPGSFDAAAVVDRVRWQLAEDGQGIFGSGVAGVHIEPEAVDDAAHHSKGLFGAGPDERVHHALSRVQAMLGHRGVVTPTIGGGRWLAERQVLVPWGDRAVTAKDRARPWPGSLPDPLPATVYPEPRLVEVTDIAGAPVTVGERDVLSAPPAVLVTGERRSRIREWAGPWPISERGWDPLRRRRAHRFQVVDADGGAWLLVVEEGEWRAEGRYD
>NC_015125.1|WP_013585862.1|3002650_3003208_+|cysteine-hydrolase
MTRALIVIDMQRGFDDLAFWGPTANPECEANVAALIERWGREGEPIVIVRHDSPKEGSPLHPSAPGNALVSAVAAVEPDVLVSKSVNSAFYGDPDLQAWLEERGIRDLVICGIQTNMCVETTARMAGNLGYDVTVALDATRTFDLTGEVAGVGTVSRTAAELMAETALVLQQGGFARIVRTADLL
>NC_015125.1|WP_013585861.1|3002081_3002579_+|HNH-endonuclease
MRTLVLNAGYEPLAVVSFKRALVLVMNEKATVVECVDEDPVWAAGGTYDRPAVIILTRYIRVPGARQVPVTRRGVLRRDAHRCGYCGKTASTIDHVLPRSRGGKDTWENLVACCLRCNNVKGDRTPQEMSWELKIIPAPPRGSSWTVRGVDKSDPRWEPYLALAA
>NC_015125.1|WP_099046956.1|3001040_3001736_+|M23-family-metallopeptidase
MVAGLVATVAIPAYAATVPTANTMTLGEMSAPDNQSMVVASDVANETLDRSSYSATTADEIQKKKDQEAAAAAAAERARQLAANAGASLSNIDLNMTAPGSGEVRWPLTSYVLGRGLWDSGYHQGVDLLAPGGQPIFAAAAGVVSTSSESFGGYGVGIVIQHVINGQKVSTTYGHMTYGSRQVQAGDTVAAGQLIGLVGSTGSSTANHLHFEVHINDQVVDPYAWLQQNAG
>NC_015125.1|WP_043362980.1|3015918_3016779_+|3-hydroxyacyl-CoA-dehydrogenase-family-protein
MANAGSPASLPATVGVLGGGRMGAGIAHAFLLAGARVHVVERDAAAAGQARERVETALARSVERGTKIPDADFLTTGDDADAFAEAGLVIEAVPEDRDLKLDALARIEGAVRGDAVVASNTSSISIDALAASLGRPERFLGLHFFNPVPASALVEVVTGSATLPGVVSAATNWVEAIGKTAVVVRDAPGFASSRLGVALGLEAIRMLEEGVASAHDIDTAMELGYRHPMGPLRTTDIVGLDVRLGIAEELERAFGARFTPPALLRELVAQGHLGRKTGRGFYEWSE
>NC_015125.1|WP_148272885.1|3016775_3018830_+|phenylacetic-acid-degradation-bifunctional-protein-PaaZ
MMTFLPSYVNGAWWAPGSDPDAAIVRDASTGEEIVRISTRGLDLAGAIAYARREGQKNLGALTFPQRAMVLKNLAIALNERREELYALSERSGSTRRDSLSDIDGGIGVLFTFSSKARRELPAGKVVLDGPIEPLSKDGSFLGRHVYTRLPGVAVQINAFNFPMWGALEKFAPAFLAGLPTIVKPATPTAYVAEAWVRMVVATGLLPEGSLQLVSGSVPGLFDLLDLGDTVGFTGSASTAERLRAQAKPGVRFTSETDSINASILGPDAVPGTPEFDAYVKQLLVELTTKAGQKCTAIRRAIVPRGTTDAVAEALRAKIAERVVIGDPRAEGVTMGPVVSLAQRDEVLRQVRALEEAGGRFVVGSADAPEGAPADGAFLQPMLLAFADATTPAVNDIEAFGPVASIVEYADVADAATIVARGGGSLVTSVATHDPDVATELLTRMGAMNGRVLFLDRDDARTSTGHGAPVPHLVHGGPGRAGGGEELGGIRSVLHYMQRTAIQGSPRMLTALTGVWHPGAETDSAGTHPFRKPLSDLRIGDAVESAEREVTLDDIEVFANFTGDTFYAHMDEESAAANPFFPGRVAHGYLLVSWAAGLFVDPAPGPVLANSGLENLRFVTPVSPGDRIRVALTAKQITPRETDEYGEVRWDAVIRNQDDEIVAQYDVLTLVAKTWAPAPVAVPA
>NC_015125.1|WP_013585874.1|3018826_3019519_+|hydroxyphenylacetyl-CoA-thioesterase-PaaI
MSLRPMMRNDRASAMLGMVVEHDEPGESRVSMTVRDDMLNGFAITHGGLVFTLADTAFAIACNEDERVTVAGGADITFLKSTTAGQTLTATAERRARSGRTGLYDIRVTDEKGDLVAEVRGRSITTDRRPPVPVPSTGSGTSDARVAEPVEASGPRSASVPVPSTSSGTSAAPVAERVEASGRRSAAVPVPSTSSGTSAAPVAEPVEASGPQPSNDPERDGALRTTEVSR
>NC_015125.1|WP_013585875.1|3019515_3020826_+|phenylacetate--CoA-ligase
MTLTTASRPDFLASVDPTGIPLESLRALQLERLQWTVRHAYDNVALYRRKFDEAGVGPDDIRSLDDIRLLPFTTKADLRETYPFGMFAVPMPDVRRIHASSGTTGRPTVVGYTAGDLDRWADLVARSLSAAGIRAGDRVHNAYGYGLFTGGLGAHAGIERLGATVIPMSGGQTARQAQLIQDFEPDAILCTPSYLLTIADALEAAGVDPRSTSLRVAVLGAEPWTNEMRREIERRLDIVAVDIYGLSEVMGPGVASESALTKDGPHIWEDHFLPETIDGDTGAPVADGELGELVFTSLTKEAFPVIRYRTRDLTRLQPGTAFPAMRRIEKITGRNDDMIILRGVNLFPTQIEEIVLGIEKLTPHFVLELRREGRMDAMTVRIERHPALEREVCEAAGVVLQQRIKVLIGTSVDVRVEEPGTLPRSEGKYKRVYDLR
>NC_015125.1|WP_013585876.1|3020956_3021619_-|HAD-family-hydrolase
MADTAIFDVDGTLVDTNYQHALAWYRSFLRFDIVLPIWRIHRAIGMGGDQLVPSLTSDDVENAHGEALRAAWTEEFEPFIDEVRPFNGAHDLLVAVKERGFQVVLASSGKSDHVEHFLDLVDARDLADAWTTSDDVEASKPAPDLVQTALDRVPGSGGIMIGDSPWDAIAAAKAHIPTVAVRTGGFAPEELRDAGAVEVFDSLRDLIAGLDDTPLARAGS
>NC_015125.1|WP_013585877.1|3021722_3022682_+|1,2-phenylacetyl-CoA-epoxidase-subunit-A
MTMTAPLPDAAEGEAMFDALIEADGRIEPRDWMPEGYRRTLIRQISQHAHSEIIGMQPEGAWITRAPSLKRKSILLAKVQDEAGHGLYLYSAAQTLGITRDEMTQQLVDGKARYSSIFNYPTPTWADMGAIGWLVDGAAICNQVPLCRASYGPYGRAMVRICKEESFHQRQGFEILLTLMQGTDEQREMAQDAVNRWYWPSLMMFGPPDDDSPNSAQSTAWNIKRFSNDVLRQRFVSMLVPQAAVLGVTLPDPDLRFNEETGEYDMGEIDWSEFHEVLAGRGPLNTMRRQHRRDAHEEGAWVREAAAAYAAKKSAKVAA
>NC_015125.1|WP_013585878.1|3022681_3022987_+|1,2-phenylacetyl-CoA-epoxidase-subunit-B
MATPGGSPAETWPLWEVFVRANRGLSHVHVGSLHAPDAELAVRNARDLYTRRGEGVSVWVVPSDAVTTSDPGQKGAFFESPAGKNYRHAVYYTASEGVPHL
>NC_015125.1|WP_013585879.1|3023187_3024024_+|phenylacetate-CoA-oxygenase-subunit-PaaC
MAEPVDAPDPHGDVSLDARELGAELAGGEDRTTDPDVAAYALRLGDDALILAQNLCGWIARAPEIEEDVALGNIALDLLGHARSLLRYAGSYDGRSEDDLAYWRDEPDFRSAWLFELPNGDFAHTIARQLLASTYLLELYRDLTASTDPVLAAVAAKAEKEVDYHRDHAVQWTLRLAGGTDESRRRFLVALDDTWPYLDELFRDEPLHERLDGIAVRPSSLRTRADEVLAAVLAEEDVPVPAIPASSAGGRRGIHHPSFGPLIAEMQVLARRHPGATW
>NC_015125.1|WP_013585880.1|3024017_3024497_+|phenylacetate-CoA-oxygenase-subunit-PaaJ
MVSVEHAREVAAAVVDPEVPVLTIDDLGVLRDVRVDGDTVTVTITPTYSGCPAVEAIRDDIVLALTSAGFDNAVVRTTLTPAWTTDWMSDEGRRKLSEYGIAPPTGRAPAGPIRLTLSVVCPRCGSLDTRELSRFGSTSCKSLWECRACLEPFDHFKAL
>NC_015125.1|WP_013585881.1|3024496_3025636_+|phenylacetate-CoA-oxygenase/reductase-subunit-PaaK
MTMTDATAAGPAATPAPRARARFHTLRVADVRPLTPTAIEVTFAVPDDIADAFDYAPGQYVALRATVDGEELRRSYSLCRPPARGTISVGIKRDPDGRFSSWAHEGLRPGDEIDVMSPQGTFVSRASTSTGHVVAIAAGSGITPIMALAADVLERSADARMTIVYANRSSTDVMFVDELADLKDRYPSRLTLHHVLSREQRAAPVFSGRLDEERLRLILSRLIDPASVDEWFLCGPFALVEVCREALAEAGVPRERVRFELFTAGDGNAPAQTGGARPVRVRADEPVRSIEITLDGQSAHVDSPVSANETILAAALRVRPDVPFACAGGVCGTCRARVIEGSVSMTENYALEPDEIERGYVLTCQSHPTSDTVRVDYDG

Crispr_ID: NC_015125_15

• CRISPR_ID: NC_015125_15
• CRISPR_location: 3023002-3023116
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_15

Consensus_repeat	Method
AGCGGGTCCCGGTCCCTTCGACAGGCTCAGGGACCTGACG	CRISPRCasFinder

spacers of NC_015125_15

>15.1|3023042|35|NC_015125|CRISPRCasFinder
CGGCTGCGGTGGCTGAGCCTGTCGACGCCCCCCAG

CRISPR arrays and Neighbor proteins around NC_015125_15

CRISPR arrays

The CRISPR arrays of NC_015125_15

>merge|NC_015125|15|3023002-3023116|CRISPRCasFinder
AGCGGGTCCCGGTCCCTTCGACAGGCTCAGGGACCTGACGCGGCTGCGGTGGCTGAGCCTGTCGACGCCCCCCAGAGCGGGTCCCGGTCCCTTCGACAGGCTCAGGGACCTGACG

>NC_015125|15|14|3023002-3023116|CRISPRCasFinder
AGCGGGTCCCGGTCCCTTCGACAGGCTCAGGGACCTGACG	CGGCTGCGGTGGCTGAGCCTGTCGACGCCCCCCAG
AGCGGGTCCCGGTCCCTTCGACAGGCTCAGGGACCTGACG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013585887.1|3028995_3030612_+|cation/acetate-symporter-ActP	unknown	unknown	gnl|CDD|236495
NC_015125.1|WP_013585884.1|3027238_3027523_-|hypothetical-protein	unknown	unknown	gnl|CDD|223393
NC_015125.1|WP_013585876.1|3020956_3021619_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|223620
NC_015125.1|WP_013585885.1|3027648_3028500_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|99777
NC_015125.1|WP_013585880.1|3024017_3024497_+|phenylacetate-CoA-oxygenase-subunit-PaaJ	unknown	unknown	gnl|CDD|131214
NC_015125.1|WP_043362980.1|3015918_3016779_+|3-hydroxyacyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|224170
NC_015125.1|WP_013585874.1|3018826_3019519_+|hydroxyphenylacetyl-CoA-thioesterase-PaaI	unknown	unknown	gnl|CDD|131339
NC_015125.1|WP_013585883.1|3026447_3027182_+|hypothetical-protein	unknown	unknown	gnl|CDD|274856
NC_015125.1|WP_158309757.1|3012637_3013501_+|DUF4436-family-protein	unknown	unknown	gnl|CDD|379624
NC_015125.1|WP_013585871.1|3014974_3015889_+|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|119339
NC_015125.1|WP_013585879.1|3023187_3024024_+|phenylacetate-CoA-oxygenase-subunit-PaaC	unknown	unknown	gnl|CDD|368300
NC_015125.1|WP_013585870.1|3013791_3014982_+|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl|CDD|238383
NC_015125.1|WP_013585888.1|3030772_3031306_-|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl|CDD|223427
NC_015125.1|WP_013585886.1|3028645_3028999_+|DUF485-domain-containing-protein	unknown	unknown	gnl|CDD|377315
NC_015125.1|WP_013585877.1|3021722_3022682_+|1,2-phenylacetyl-CoA-epoxidase-subunit-A	unknown	unknown	gnl|CDD|184320
NC_015125.1|WP_148272885.1|3016775_3018830_+|phenylacetic-acid-degradation-bifunctional-protein-PaaZ	unknown	unknown	gnl|CDD|236931
NC_015125.1|WP_013585882.1|3025643_3026414_+|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|235852
NC_015125.1|WP_013585878.1|3022681_3022987_+|1,2-phenylacetyl-CoA-epoxidase-subunit-B	unknown	unknown	gnl|CDD|237504
NC_015125.1|WP_013585881.1|3024496_3025636_+|phenylacetate-CoA-oxygenase/reductase-subunit-PaaK	unknown	unknown	gnl|CDD|131215
NC_015125.1|WP_013585875.1|3019515_3020826_+|phenylacetate--CoA-ligase	unknown	unknown	gnl|CDD|131210

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013585887.1|3028995_3030612_+|cation/acetate-symporter-ActP	gnl|CDD|236495	PRK09395, actP, cation/acetate symporter ActP.	0
NC_015125.1|WP_013585884.1|3027238_3027523_-|hypothetical-protein	gnl|CDD|223393	COG0316, sufA, Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones].	6.10668e-07
NC_015125.1|WP_013585876.1|3020956_3021619_-|HAD-family-hydrolase	gnl|CDD|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	1.93616e-31
NC_015125.1|WP_013585885.1|3027648_3028500_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|99777	cd06170, LuxR_C_like, C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.	6.15063e-14
NC_015125.1|WP_013585880.1|3024017_3024497_+|phenylacetate-CoA-oxygenase-subunit-PaaJ	gnl|CDD|131214	TIGR02159, Putative_12-phenylacetyl-CoA_epoxidase_subunit_D, phenylacetate-CoA oxygenase, PaaJ subunit. Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other].	4.57323e-61
NC_015125.1|WP_043362980.1|3015918_3016779_+|3-hydroxyacyl-CoA-dehydrogenase-family-protein	gnl|CDD|224170	COG1250, FadB, 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism].	5.41556e-96
NC_015125.1|WP_013585874.1|3018826_3019519_+|hydroxyphenylacetyl-CoA-thioesterase-PaaI	gnl|CDD|131339	TIGR02286, Acyl-coenzyme_A_thioesterase_PaaI, phenylacetic acid degradation protein PaaD. This member of the domain family TIGR00369 (which is, in turn, a member of the pfam03061 thioesterase superfamily) is nearly always found adjacent to other genes of the phenylacetic acid degradation pathway. Its function is currently unknown, but a role as a thioesterase is not inconsistent with the proposed overall pathway. Sequences scoring between trusted and noise include those from archaea and other species not known to catabolize phenylacetic acid and which are not adjacent to other genes potentially involved with such a pathway.	8.06863e-37
NC_015125.1|WP_013585883.1|3026447_3027182_+|hypothetical-protein	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	0.00723708
NC_015125.1|WP_158309757.1|3012637_3013501_+|DUF4436-family-protein	gnl|CDD|379624	pfam14494, DUF4436, Domain of unknown function (DUF4436). This is a family of membrane and transmembrane proteins from mycobacterial and related species. The function is not known.	2.36037e-91
NC_015125.1|WP_013585871.1|3014974_3015889_+|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	6.03004e-59
NC_015125.1|WP_013585879.1|3023187_3024024_+|phenylacetate-CoA-oxygenase-subunit-PaaC	gnl|CDD|368300	pfam05138, PaaA_PaaC, Phenylacetic acid catabolic protein. This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid. These proteins may form part of a dioxygenase complex.	1.66399e-89
NC_015125.1|WP_013585870.1|3013791_3014982_+|acetyl-CoA-C-acyltransferase	gnl|CDD|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.36189e-179
NC_015125.1|WP_013585888.1|3030772_3031306_-|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl|CDD|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	8.00082e-38
NC_015125.1|WP_013585886.1|3028645_3028999_+|DUF485-domain-containing-protein	gnl|CDD|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	5.55922e-35
NC_015125.1|WP_013585877.1|3021722_3022682_+|1,2-phenylacetyl-CoA-epoxidase-subunit-A	gnl|CDD|184320	PRK13778, paaA, phenylacetate-CoA oxygenase subunit PaaA; Provisional.	0
NC_015125.1|WP_148272885.1|3016775_3018830_+|phenylacetic-acid-degradation-bifunctional-protein-PaaZ	gnl|CDD|236931	PRK11563, PRK11563, bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional.	0
NC_015125.1|WP_013585882.1|3025643_3026414_+|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|235852	PRK06688, PRK06688, enoyl-CoA hydratase; Provisional.	2.68599e-52
NC_015125.1|WP_013585878.1|3022681_3022987_+|1,2-phenylacetyl-CoA-epoxidase-subunit-B	gnl|CDD|237504	PRK13781, paaB, phenylacetate-CoA oxygenase subunit PaaB; Provisional.	1.0126e-55
NC_015125.1|WP_013585881.1|3024496_3025636_+|phenylacetate-CoA-oxygenase/reductase-subunit-PaaK	gnl|CDD|131215	TIGR02160, 12-phenylacetyl-CoA_epoxidase_subunit_E, phenylacetate-CoA oxygenase/reductase, PaaK subunit. Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other].	1.0208e-154
NC_015125.1|WP_013585875.1|3019515_3020826_+|phenylacetate--CoA-ligase	gnl|CDD|131210	TIGR02155, Phenylacetate-coenzyme_A_ligase, phenylacetate-CoA ligase. Phenylacetate-CoA ligase (PA-CoA ligase) catalyzes the first step in aromatic catabolism of phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Often located in a conserved gene cluster with enzymes involved in phenylacetic acid activation (paaG/H/I/J), phenylacetate-CoA ligase has been found among the proteobacteria as well as in gram positive prokaryotes. In the B-subclass proteobacterium Azoarcus evansii, phenylacetate-CoA ligase has been shown to be induced under aerobic and anaerobic growth conditions. It remains unclear however, whether this induction is due to the same enzyme or to another isoenzyme restricted to specific anaerobic growth conditions. [Energy metabolism, Other].	0

Protein sequences

>NC_015125.1|WP_013585878.1|3022681_3022987_+|1,2-phenylacetyl-CoA-epoxidase-subunit-B
MATPGGSPAETWPLWEVFVRANRGLSHVHVGSLHAPDAELAVRNARDLYTRRGEGVSVWVVPSDAVTTSDPGQKGAFFESPAGKNYRHAVYYTASEGVPHL
>NC_015125.1|WP_013585877.1|3021722_3022682_+|1,2-phenylacetyl-CoA-epoxidase-subunit-A
MTMTAPLPDAAEGEAMFDALIEADGRIEPRDWMPEGYRRTLIRQISQHAHSEIIGMQPEGAWITRAPSLKRKSILLAKVQDEAGHGLYLYSAAQTLGITRDEMTQQLVDGKARYSSIFNYPTPTWADMGAIGWLVDGAAICNQVPLCRASYGPYGRAMVRICKEESFHQRQGFEILLTLMQGTDEQREMAQDAVNRWYWPSLMMFGPPDDDSPNSAQSTAWNIKRFSNDVLRQRFVSMLVPQAAVLGVTLPDPDLRFNEETGEYDMGEIDWSEFHEVLAGRGPLNTMRRQHRRDAHEEGAWVREAAAAYAAKKSAKVAA
>NC_015125.1|WP_013585876.1|3020956_3021619_-|HAD-family-hydrolase
MADTAIFDVDGTLVDTNYQHALAWYRSFLRFDIVLPIWRIHRAIGMGGDQLVPSLTSDDVENAHGEALRAAWTEEFEPFIDEVRPFNGAHDLLVAVKERGFQVVLASSGKSDHVEHFLDLVDARDLADAWTTSDDVEASKPAPDLVQTALDRVPGSGGIMIGDSPWDAIAAAKAHIPTVAVRTGGFAPEELRDAGAVEVFDSLRDLIAGLDDTPLARAGS
>NC_015125.1|WP_013585875.1|3019515_3020826_+|phenylacetate--CoA-ligase
MTLTTASRPDFLASVDPTGIPLESLRALQLERLQWTVRHAYDNVALYRRKFDEAGVGPDDIRSLDDIRLLPFTTKADLRETYPFGMFAVPMPDVRRIHASSGTTGRPTVVGYTAGDLDRWADLVARSLSAAGIRAGDRVHNAYGYGLFTGGLGAHAGIERLGATVIPMSGGQTARQAQLIQDFEPDAILCTPSYLLTIADALEAAGVDPRSTSLRVAVLGAEPWTNEMRREIERRLDIVAVDIYGLSEVMGPGVASESALTKDGPHIWEDHFLPETIDGDTGAPVADGELGELVFTSLTKEAFPVIRYRTRDLTRLQPGTAFPAMRRIEKITGRNDDMIILRGVNLFPTQIEEIVLGIEKLTPHFVLELRREGRMDAMTVRIERHPALEREVCEAAGVVLQQRIKVLIGTSVDVRVEEPGTLPRSEGKYKRVYDLR
>NC_015125.1|WP_013585874.1|3018826_3019519_+|hydroxyphenylacetyl-CoA-thioesterase-PaaI
MSLRPMMRNDRASAMLGMVVEHDEPGESRVSMTVRDDMLNGFAITHGGLVFTLADTAFAIACNEDERVTVAGGADITFLKSTTAGQTLTATAERRARSGRTGLYDIRVTDEKGDLVAEVRGRSITTDRRPPVPVPSTGSGTSDARVAEPVEASGPRSASVPVPSTSSGTSAAPVAERVEASGRRSAAVPVPSTSSGTSAAPVAEPVEASGPQPSNDPERDGALRTTEVSR
>NC_015125.1|WP_148272885.1|3016775_3018830_+|phenylacetic-acid-degradation-bifunctional-protein-PaaZ
MMTFLPSYVNGAWWAPGSDPDAAIVRDASTGEEIVRISTRGLDLAGAIAYARREGQKNLGALTFPQRAMVLKNLAIALNERREELYALSERSGSTRRDSLSDIDGGIGVLFTFSSKARRELPAGKVVLDGPIEPLSKDGSFLGRHVYTRLPGVAVQINAFNFPMWGALEKFAPAFLAGLPTIVKPATPTAYVAEAWVRMVVATGLLPEGSLQLVSGSVPGLFDLLDLGDTVGFTGSASTAERLRAQAKPGVRFTSETDSINASILGPDAVPGTPEFDAYVKQLLVELTTKAGQKCTAIRRAIVPRGTTDAVAEALRAKIAERVVIGDPRAEGVTMGPVVSLAQRDEVLRQVRALEEAGGRFVVGSADAPEGAPADGAFLQPMLLAFADATTPAVNDIEAFGPVASIVEYADVADAATIVARGGGSLVTSVATHDPDVATELLTRMGAMNGRVLFLDRDDARTSTGHGAPVPHLVHGGPGRAGGGEELGGIRSVLHYMQRTAIQGSPRMLTALTGVWHPGAETDSAGTHPFRKPLSDLRIGDAVESAEREVTLDDIEVFANFTGDTFYAHMDEESAAANPFFPGRVAHGYLLVSWAAGLFVDPAPGPVLANSGLENLRFVTPVSPGDRIRVALTAKQITPRETDEYGEVRWDAVIRNQDDEIVAQYDVLTLVAKTWAPAPVAVPA
>NC_015125.1|WP_043362980.1|3015918_3016779_+|3-hydroxyacyl-CoA-dehydrogenase-family-protein
MANAGSPASLPATVGVLGGGRMGAGIAHAFLLAGARVHVVERDAAAAGQARERVETALARSVERGTKIPDADFLTTGDDADAFAEAGLVIEAVPEDRDLKLDALARIEGAVRGDAVVASNTSSISIDALAASLGRPERFLGLHFFNPVPASALVEVVTGSATLPGVVSAATNWVEAIGKTAVVVRDAPGFASSRLGVALGLEAIRMLEEGVASAHDIDTAMELGYRHPMGPLRTTDIVGLDVRLGIAEELERAFGARFTPPALLRELVAQGHLGRKTGRGFYEWSE
>NC_015125.1|WP_013585871.1|3014974_3015889_+|enoyl-CoA-hydratase/isomerase-family-protein
MAEGAGVPGASTGSATSAGEAPEGVEGTEALVGRVPGASTGSATSAGEVPEPVEGTGILSAPRLRIEARDDRVVATLDRPERRNAIDQAMIDELHALCAELEERPRTLILTGAGGIFAAGADIAQLRERTGDDARRGINATAFDRIRHLPMPVIAAIDGFALGGGAELAYAADIRIGTPRVRFGNPEPGLGIIAAAGAAWRLPEIVGHARASELLLTARMIDADEALAWGLLSSIHEPDALLDAAHAIADRIAANSVRATILTKRALLAPRAEHPTIDGDLQAELFDSADKRARMTAFLERKKK
>NC_015125.1|WP_013585870.1|3013791_3014982_+|acetyl-CoA-C-acyltransferase
MSQAFLIGGARTPVGRYGGALASVRPDDLAALVVGEAVARAGVPAEAIDEVILGAANQAGEDNRNVARMAVLLAGLPDAIPGLTVNRLCASGMSAIALAAQAVRAGDADIVVAGGVESMTRAPWVQAKPAKAWAKPGEAFDTSIGWRFTNPRLAARDRATFTMPETAEEVARVDGISRADADAFALRSHERAIRAQDAGHFRDEIVGVETPRGLVDTDEGPRRDTSLEVLAGLRPVVKGGEVVTAGNASSLNDGASAIVVASAAAVERYGLRARARIVAHASAGVAPEVMGLGPVPATEKALAKARLSASDLGAVELNEAFASQSLACMRRLGLDPEIVNADGGAIALGHPLGSSGSRLLVTLLGRLEREEARYGLATMCVGVGQGTAMIVERVDG
>NC_015125.1|WP_158309757.1|3012637_3013501_+|DUF4436-family-protein
MSSTARPGHRTAVGVGGIVVAIIALYVTVVVLYASGSGVVSRGDDEVSPGAVSLVLTPEKMDAATSRLTVSLLPKQADGGEYTNGVTIDKPFAVLVSAVAGSTAVHYQPSELVAPTEVSFVMDGAIEQWPFDRYHVTSFVVAAVDDADGESVPLPTAVTVSGRGVTGWDITMAERDAGDGLLAVDISASRSGATVAFGIVLLTLMVIIPTLVLIVAIAVLRGRRKVEVTTLGWMGAMVFATIPLRNFLPGSPPIGSWIDYLIVLWVIAALVAGLVIFVIAWWRRGPA
>NC_015125.1|WP_013585879.1|3023187_3024024_+|phenylacetate-CoA-oxygenase-subunit-PaaC
MAEPVDAPDPHGDVSLDARELGAELAGGEDRTTDPDVAAYALRLGDDALILAQNLCGWIARAPEIEEDVALGNIALDLLGHARSLLRYAGSYDGRSEDDLAYWRDEPDFRSAWLFELPNGDFAHTIARQLLASTYLLELYRDLTASTDPVLAAVAAKAEKEVDYHRDHAVQWTLRLAGGTDESRRRFLVALDDTWPYLDELFRDEPLHERLDGIAVRPSSLRTRADEVLAAVLAEEDVPVPAIPASSAGGRRGIHHPSFGPLIAEMQVLARRHPGATW
>NC_015125.1|WP_013585880.1|3024017_3024497_+|phenylacetate-CoA-oxygenase-subunit-PaaJ
MVSVEHAREVAAAVVDPEVPVLTIDDLGVLRDVRVDGDTVTVTITPTYSGCPAVEAIRDDIVLALTSAGFDNAVVRTTLTPAWTTDWMSDEGRRKLSEYGIAPPTGRAPAGPIRLTLSVVCPRCGSLDTRELSRFGSTSCKSLWECRACLEPFDHFKAL
>NC_015125.1|WP_013585881.1|3024496_3025636_+|phenylacetate-CoA-oxygenase/reductase-subunit-PaaK
MTMTDATAAGPAATPAPRARARFHTLRVADVRPLTPTAIEVTFAVPDDIADAFDYAPGQYVALRATVDGEELRRSYSLCRPPARGTISVGIKRDPDGRFSSWAHEGLRPGDEIDVMSPQGTFVSRASTSTGHVVAIAAGSGITPIMALAADVLERSADARMTIVYANRSSTDVMFVDELADLKDRYPSRLTLHHVLSREQRAAPVFSGRLDEERLRLILSRLIDPASVDEWFLCGPFALVEVCREALAEAGVPRERVRFELFTAGDGNAPAQTGGARPVRVRADEPVRSIEITLDGQSAHVDSPVSANETILAAALRVRPDVPFACAGGVCGTCRARVIEGSVSMTENYALEPDEIERGYVLTCQSHPTSDTVRVDYDG
>NC_015125.1|WP_013585882.1|3025643_3026414_+|enoyl-CoA-hydratase/isomerase-family-protein
MIDYSHADDLAIITLNAPARRNALGLDALGALAEAYDRAEADGARAVLLRGEGPSFCAGRDIAGVDPATDDVAGYLEATLAPLLRRMASFPAPTFAAAHGACLGVGLGLLIATDVVFVADTAKVGSPFAALGATLDSGGHALFAERLGTHATLDLIYTGRMLTGEEAVRAGLFSRVVPASEIQDATELAARRAAAGPTEAFRASKRIVTAIRDERLGLWEAMALENRAQAALARTDDYREGFAAFQAKRTPEFRGR
>NC_015125.1|WP_013585883.1|3026447_3027182_+|hypothetical-protein
MSIDEEDELAQLRRRAYSPSADIASDPDALRRLIELEARANATEQAPASAPAVPEEPVAPAESEIPDATPARPRITRPRLRRSTVILLAAAALVVATLATVLVVVQRVQTDPLQAGATQIARLAPDPDFEVPSSLTVGITGNVTAFEEFEGFRVISQPSYYDAEGAARCMTVWQPELLDTAGGGGFSYDGEFFLSTCGAGSFPANMTMLLRDGTPERAQTDFPAGTALQFVYDAVNNEIVIFRG
>NC_015125.1|WP_013585884.1|3027238_3027523_-|hypothetical-protein
MLTLTEEATTAVKTITAQYPDAAQGGVRIEGAGSPESQFSLSVVDGPQPQDAVVEHAGARVFLDTDAAAVLDDRVLDAQIDPQGSVQFAVTSAA
>NC_015125.1|WP_013585885.1|3027648_3028500_-|helix-turn-helix-transcriptional-regulator
MGAPTVLRDDATLVSHAVAELARRTHFPLAFGGLEHNGAVHVTTIVGARTRSIEGLVVRAERGLGGRALVERRPRMTLDYRTARSITHDYDRAILGEGIATLFAVPVLVRGHARGVLYCGSWAQAPVGDIEARPAFDVAGELGTELRVREEVDRRLSTMPSGDNGLSVGVREEIRESYAQLRSIAATVGDDDVRRRLEELEARLAALTGDAPRSGEDADIHLSRREIDVLACAAVGSTNGEIAASLHLRETTVKSYLASAMAKLDASTRHAAVARARRAGLLP
>NC_015125.1|WP_013585886.1|3028645_3028999_+|DUF485-domain-containing-protein
MTDRRIDPAPGGGVDYIAVEESAPFRDLKKRQRSFIFPLAVAFLVWYFVYVLLSSFAPEFMAQPVFGAVTVGLLFGLGQFVTTFAITMGYVAYANRRLDPLAEQLRDELERTERGTA
>NC_015125.1|WP_013585887.1|3028995_3030612_+|cation/acetate-symporter-ActP
MNEVFGTVHAAVQTVENNPVLNISIFGAFVAVTLFIVIRASRNSKTAADYYAAGRSFTGPQNGFAIAGDYLSAASFLGIVGAIAINGYDGFLYSIGFLVAWLVALLLVAELMRNTGKFTMADVLSFRLRERPVRMAAAITTLAVCFFYLLAQMAGAGGLVSLLLGITERLGQSIVVAVVGLLMIVYVLIGGMKGTTWVQIVKAFLLIGGAVVMTIWVLAINGFNLNTLLEAAVAASPKGEAVLAPGLQYGKNPWDFISLALALVLGTAGLPHVLMRFYTVPTAKEARRSVVWAIWLIGLFYILTLVLGYGAGALVGPDAILAAPGGVNAAAPLLALALGGPILLGFISAVAFATILAVVAGLTITAAASFAHDIYASVVKKGNVPPDGEVKVARRTVIVIGVLAIIGGIGVQGQNVAFLVALAFAVAASANLPTILYSLFWRRFTTRGAVWSMYGGLGSALVLIFLSPVFWGTPTSVFVDAGVAIWPLNNPGIVSIPLGFLLGWLGSITSRRAEDAGKAAEMDVRSLTGFGAEKASTH
>NC_015125.1|WP_013585888.1|3030772_3031306_-|methylated-DNA--[protein]-cysteine-S-methyltransferase
MNTVTSTEYDSPIGPILLTFVNDALVRLDVAHDGIDLARAEIAQRLGVLPEPDPDGAVDLREQLDEYFDGARRHFEVPLDWRLVQGFTRTALQATIDIPYGEMASYGEVAILAGAPGAARAVGTACAKSPFSIVVPVHRVVRADGSIGEYGGHPEVKEYLLSLENDVVLGEGLRGTG

Crispr_ID: NC_015125_16

• CRISPR_ID: NC_015125_16
• CRISPR_location: 3058092-3058194
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_16

Consensus_repeat	Method
GGGTGCCGGTCCCTTCGACGGGCTCAGGGACCTCGGT	CRISPRCasFinder

spacers of NC_015125_16

>16.1|3058129|29|NC_015125|CRISPRCasFinder
GGGGCTCAGGGACCTCGGTTCGGGGGTGG

CRISPR arrays and Neighbor proteins around NC_015125_16

CRISPR arrays

The CRISPR arrays of NC_015125_16

>merge|NC_015125|16|3058092-3058194|CRISPRCasFinder
GGGTGCCGGTCCCTTCGACGGGCTCAGGGACCTCGGTGGGGCTCAGGGACCTCGGTTCGGGGGTGGGGGTGCCGGTCCCGTCGACGGGCTCAGGGACCTCGGT

>NC_015125|16|15|3058092-3058194|CRISPRCasFinder
GGGTGCCGGTCCCTTCGACGGGCTCAGGGACCTCGGT	GGGGCTCAGGGACCTCGGTTCGGGGGTGG
GGGTGCCGGTCCCGTCGACGGGCTCAGGGACCTCGGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013585914.1|3057601_3058078_+|YbaK/EbsC-family-protein	unknown	unknown	gnl|CDD|239825
NC_015125.1|WP_148272988.1|3054970_3055708_+|acetolactate-decarboxylase	unknown	unknown	gnl|CDD|377014
NC_015125.1|WP_013585919.1|3063743_3064742_+|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NC_015125.1|WP_013585912.1|3055785_3056124_+|Lsr2-family-protein	unknown	unknown	gnl|CDD|378714
NC_015125.1|WP_013585920.1|3064917_3065691_-|IclR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224332
NC_015125.1|WP_013585924.1|3068373_3069645_-|DUF445-domain-containing-protein	unknown	unknown	gnl|CDD|377281
NC_015125.1|WP_013585910.1|3054590_3054938_+|Lsr2-family-protein	unknown	unknown	gnl|CDD|378714
NC_015125.1|WP_013585915.1|3058304_3060251_-|glycogen-debranching-protein	unknown	unknown	gnl|CDD|225942
NC_015125.1|WP_013585905.1|3048522_3049320_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222
NC_015125.1|WP_013585909.1|3052943_3054431_-|amino-acid-permease	unknown	unknown	gnl|CDD|129987
NC_015125.1|WP_013585923.1|3067984_3068335_-|gamma-glutamylcyclotransferase	unknown	unknown	gnl|CDD|119400
NC_015125.1|WP_013585921.1|3065752_3067282_+|histidine-ammonia-lyase	unknown	unknown	gnl|CDD|236484
NC_015125.1|WP_013585917.1|3061158_3062304_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NC_015125.1|WP_013585922.1|3067391_3067856_-|histidine-phosphatase-family-protein	unknown	unknown	gnl|CDD|224973
NC_015125.1|WP_013585907.1|3050449_3050884_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013585908.1|3050982_3052806_-|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_013585906.1|3049316_3050366_-|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|223914
NC_015125.1|WP_043362994.1|3056175_3057249_-|Glu/Leu/Phe/Val-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|133444
NC_015125.1|WP_013585916.1|3060247_3061162_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NC_015125.1|WP_013585918.1|3062306_3063557_-|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270451

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013585914.1|3057601_3058078_+|YbaK/EbsC-family-protein	gnl|CDD|239825	cd04333, ProX_deacylase, This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro) deacylase and also the cis-acting prolyl-tRNA synthetase-editing domain (ProRS-INS). While ProX and ProRS-INS hydrolyze misacylated Ala-tRNA(Pro), the E. coli YbaK hydrolyzes misacylated Cys-tRNA(Pro). A few CD members are N-terminal, YbaK-ProX-like domains of an uncharacterized protein with a C-terminal, predicted Fe-S protein domain.	1.5926e-60
NC_015125.1|WP_148272988.1|3054970_3055708_+|acetolactate-decarboxylase	gnl|CDD|377014	pfam03306, AAL_decarboxy, Alpha-acetolactate decarboxylase.	7.60882e-84
NC_015125.1|WP_013585919.1|3063743_3064742_+|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.00429e-60
NC_015125.1|WP_013585912.1|3055785_3056124_+|Lsr2-family-protein	gnl|CDD|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	1.42613e-43
NC_015125.1|WP_013585920.1|3064917_3065691_-|IclR-family-transcriptional-regulator	gnl|CDD|224332	COG1414, IclR, Transcriptional regulator [Transcription].	9.8677e-57
NC_015125.1|WP_013585924.1|3068373_3069645_-|DUF445-domain-containing-protein	gnl|CDD|377281	pfam04286, DUF445, Protein of unknown function (DUF445). Predicted to be a membrane protein.	4.83233e-128
NC_015125.1|WP_013585910.1|3054590_3054938_+|Lsr2-family-protein	gnl|CDD|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	3.35068e-42
NC_015125.1|WP_013585915.1|3058304_3060251_-|glycogen-debranching-protein	gnl|CDD|225942	COG3408, GDB1, Glycogen debranching enzyme [Carbohydrate transport and metabolism].	3.30883e-69
NC_015125.1|WP_013585905.1|3048522_3049320_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.16051e-92
NC_015125.1|WP_013585909.1|3052943_3054431_-|amino-acid-permease	gnl|CDD|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.67145e-121
NC_015125.1|WP_013585923.1|3067984_3068335_-|gamma-glutamylcyclotransferase	gnl|CDD|119400	cd06661, GGCT_like, GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).	6.9359e-12
NC_015125.1|WP_013585917.1|3061158_3062304_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.20775e-78
NC_015125.1|WP_013585922.1|3067391_3067856_-|histidine-phosphatase-family-protein	gnl|CDD|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	1.73329e-31
NC_015125.1|WP_013585921.1|3065752_3067282_+|histidine-ammonia-lyase	gnl|CDD|236484	PRK09367, PRK09367, histidine ammonia-lyase; Provisional.	0
NC_015125.1|WP_013585906.1|3049316_3050366_-|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|223914	COG0845, AcrA, Membrane-fusion protein [Cell envelope biogenesis, outer membrane].	3.77507e-07
NC_015125.1|WP_043362994.1|3056175_3057249_-|Glu/Leu/Phe/Val-dehydrogenase-family-protein	gnl|CDD|133444	cd01075, NAD_bind_Leu_Phe_Val_DH, NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase. Amino acid dehydrogenase (DH) is a widely distributed family of enzymes that catalyzes the oxidative deamination of an amino acid to its keto acid and ammonia with concomitant reduction of NADP+. For example, leucine DH catalyzes the reversible oxidative deamination of L-leucine and several other straight or branched chain amino acids to the corresponding 2-oxoacid derivative. Amino acid DH -like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.	1.91177e-61
NC_015125.1|WP_013585916.1|3060247_3061162_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.11722e-76
NC_015125.1|WP_013585918.1|3062306_3063557_-|extracellular-solute-binding-protein	gnl|CDD|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.75795e-67

Protein sequences

>NC_015125.1|WP_013585914.1|3057601_3058078_+|YbaK/EbsC-family-protein
MNDALPTRSRLVAAALEAAGVGGQIIVLPDAASTAALAAAALDIEVGAIANSLVFWSDDEPLLVMTSGAHRVDTKGLAERLGRGAIRRATPEQVLAATGQPIGGVAPTGHPAPLTTIVDEALAAFPEIWAAGGTPHTVFPLTFDELVRLTGGTVARVD
>NC_015125.1|WP_043362994.1|3056175_3057249_-|Glu/Leu/Phe/Val-dehydrogenase-family-protein
MTHALPLPDFTHERVEVVTGSRSGLFIAVALHSSVLGSALGGARLWTYPAWSDALGDALRLSAAMTLKNASAGLDAGGGKSVIGLPPGTMLDADRRRAAFLDLGDAVESLGGLYRTAEDVGSTTEDMLTVSERTAHVVGLPEAGGGSGEPAGPTSLGVYSSLIATLERSAGVRDVAQRRITIAGLGQVGGRLAERLAAEGAVLTVTDVNPAKRALATELGAAWVEPHEAHLVAGDVFVPAGIGGVLTDEVIDALDVRAVCGPANNPLADRSGADRLAQRGILYAPDFVVNAGGVIYLDLESKQRGTRDEIMGRVAGIGDTLRRIFDEAESRGVTPLAAAEGVAAERLREGAASGALV
>NC_015125.1|WP_013585912.1|3055785_3056124_+|Lsr2-family-protein
MAKKHITQVIDDLDGSVLENGTTINFSLEGRAYEIDLSEKNARKLREAFEPFTVAARPIGSSAPGVRRSSGRRAVSSRDLADVRAWAEKNGHSINARGRISSAVLAAYDAAH
>NC_015125.1|WP_148272988.1|3054970_3055708_+|acetolactate-decarboxylase
MHPGVVTQFAVLDALLGGQYSSCITVRDARALGDTGIGCCERFGGEVVILDGEFFACTADEPPRLMGDDEKLPFVDVCSFGEAASRMVSDLDGPGLAAEIDGLLASRNLFHAIRLDGVMARVRTRVTRREEPPFRRLAEVTAEQIETVSHDVRGTIVGFWMPGLYQGVTVAGPHLHFLHDDRSFGGHVLEISVREAVLRVSAYARFELRVPTDDEFLSHELTHEEDRRIGAIEGGAAASASSVMR
>NC_015125.1|WP_013585910.1|3054590_3054938_+|Lsr2-family-protein
MAIKHITHLVDDLDGSVLEEGEGKQITFSVEGRAYEIDLSNRNADKFYDAVAPFVDAARSVSRTTTTSRRPRAARRDNDIDLGAVREWARANGHTVSDRGRVPATVLEAYSAAQS
>NC_015125.1|WP_013585909.1|3052943_3054431_-|amino-acid-permease
MSLFRTKSVEQSIADTDEPEFRLKKSLSALDLTVFGVGVVIGAGIFTLTGRAAHDVAGPAVVISFIVAAIACGLAAMCYAEFASTVPVSGSAYTFSYASLGELFAWIIGWDLILEMFLGASVVAQGWSAYLSAFLQQLGVALPAAISSGGVVDIPAILLVLVLGGLMTVGIKESLRVNLVLVAVKLFIVLFVIIAGIMFITPANYSPFVPPSVPTESTSGLTQPLLQFLSGLEPATFGVGGILAGAALVFFAYIGFDVVATTAEETKKPQRDLPIGIIASLVICTILYCAVAIVVTGMVPYDQLNPKAALAEAFAFHGQTWMATVIAAGAVAGLTTVVLTLLIGATRIIFAMSRDRLLPGALAKVHPRFRTPWVISIIVTVIVAIVAGLTPVGILEEMVNIGTLSAFVLVSVGVVVLRRKRPDLKRGFRVPFSPVLPILSAVICTYLMLNLSVETWLRFLIWLALGFAIYFAYSRQHARVGMLDVTPRIVAPPKD
>NC_015125.1|WP_013585908.1|3050982_3052806_-|hypothetical-protein
MTIPFDDAVAQALVSAADTAAGVVRGQGYGRHGVVSHTLDEFEGAYARAFAAGSVVEAEDRGLLARALDDLSVQVGEAQRRAAEERERLAELAAWTARDAVRQEQGALAPANTLVATWYDPRPADYPVSPPHISTAFTARERSRAVSDCIGGGQTSADPERLRFFVSTTGPMDAALREQMNAVRTAWTGFTASCSWVPIDRSTLLDGWQRLLDENTTDATWIGGIADAFDRAGSGTLSDLDVALATSATFPQSTQDLLVSGTLTTEQVAVAWAMLAQSPSADPSAFVRQWANVLGSLDGLPAFVRVEANRYRVPELLRAAERELAGLENSQDEDELSRAEMIRNEITYLKSVQTGDVQLYLYDRDASRIVEMIGTPGPDTTRAITYVPGTFTGMNSFYTGGVQQIAQYLTTQVPGTVAFVYKDGKFPGEQNNAQEPDLKRFLRIGEANDQDTAREAGEQLAQFQAGMRSDPSLSGVEQIGIGHSWGVANLTGSEVAGSEYDKVISLAGAGMLPDWRPNDDTTYTDLSYRDILLHFQSKGLVWDGNNPRSNGAFEHGPLYVGPDDAELDGRFVDGDEWGVLTDNHNLIASTDRDNDEALGDLKRLVEQ
>NC_015125.1|WP_013585907.1|3050449_3050884_-|hypothetical-protein
MTQSPSPSPLTWEEAKASTQATEREIVSLIPAEEVAAVDQLPEGSLLSCNEGGHAWLGGTKVTLVPGVHAEDVVRALETRFTDGRFDIRTRRNIDGDYEVQLLATSNERENYIISRYKADDTIDISSASPCFTLPEGVYPGGTF
>NC_015125.1|WP_013585906.1|3049316_3050366_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MGIARTWVFPILRLLLVALVAAALIKLAFFPDREVDASPAEPTGAIVEPRIAAARGTITNDVVVTATVAADPAVPVKSTAGGVVNKIFITQGAGVNQGDVIFNVKVPIERDPADSVDAEGKPKPAIFRYEDVTAPAGGTLSALDVLEGQDVTVGMAAGNVAPPSFSVTGTLEAAQQYRLLNRPGEASVAITGGPAPFTCTNLRLLTPLAGSNGDGDSTGAGAGGTPSSGGAGTTVTCAVPGDVTVFAGLAAELTIAGGKAENVLVVPTTAVRGAAQSGTVWVSTADGATEERPVALGLTDGTQVEITQGLNEGDEVLEFAPGAMAGSGAGDNCTTYPDGTMFCEPVPAS
>NC_015125.1|WP_013585905.1|3048522_3049320_-|ABC-transporter-ATP-binding-protein
MSLLHLEDVTRTVIPPDQPALTILSGVNLTIEPGDHVSIVGRSGSGKSTLLNLLGLLDLPTSGVISFDDRPIKSYSGARRDRLRGASIGFVFQQFNLLAGRTALENVTMPLLYSSGRTFWRRKKIAAEMLELVGLGHRMSSMPDRLSGGEQQRVAIARSLVRGPRLILADEPTGALDLDTGQSVMELIDDVAARTGAAQVVITHDPMIARRARRHFRLDRGILTPVDDPAFEPLTRREMREMAPTTEAEPEAEPEAEAEAEGEDA
>NC_015125.1|WP_013585915.1|3058304_3060251_-|glycogen-debranching-protein
MTTAPTTSPAGTTTETPPLQPLLDDAVIVLRAPTQVWSDTTGGMGGAPVHGVYHGDVRHVRALTLTCDDSPVEWISTAPDGASRLVLGGLLRGLDDTTPDPKVRLLRDRRVADGHVSETWTLRSRVDRPISTTLRLSLVPEFAQLHEVKSGHAHDRDAAVDIDGERATVDAGAQGLELVAPGGQVASGSDGLAVRWDVEVPAFGSAEVAWTLTLRDDTLVVGAATAPPRWDAASVAASAPDPRLSRWVRTALDDLDALRLVLPEHPDDEFFAAGAPWFFTLFGRDSLWAARLALPLDREIAASTLRVLARLQATEDDAQTAQEPGKILHELRASALEMPGEGIVLPPKYYGSVDSTPLWICLLADAWRAGMPEAEVRELLPALRAALGWIRDSGDSDGDGFLDYIDRLGTGLSNQGWKDSGDSIQWRDGRLAEGPIALCEVQGYAYEAALAGAELLEEFGEGTDAADAAFWRAWAADLKARFADTYWVETPEGRYPAVALDRDKRPVDTLTSNIGHLIGTGLLSAEEEAHVARLLLGESMSSGYGIRTMSTDAAGYWPLSYHGGSVWVHDTAIAAHGMLRAGLRDEARAVVDGLLDAAEGFDYRVPELHAGDPRSHSSVPTPYPAACRPQAWSAAAAVVCLSALAPGA
>NC_015125.1|WP_013585916.1|3060247_3061162_-|carbohydrate-ABC-transporter-permease
MTATASPQTTVLAEQRLDRPTRPAKHRLSRRALGWQIGLYALLIVLALIYIYPFLVQVATSFKTDAAAAADPISLAPQPFTWAAYERLFLNSDFPVWFGNSVVVTVFVTAGRVFFNSLAGYALARLQFRGRGIVFAGLIAVMAVPTVVLLIPKFLVINQLGIYDSYAGMILPLLVDAAGVFIMKNFFESIPPSVEEQARIDGAGTFRIFWSVVLPMARPALITIVILSFQGSWNELSHFVISTQSPELTTLTKGVASLASGQLSQGSQFPLKLAAAAIMTIPVAVVFFIFQRRIMNASEGAVKE
>NC_015125.1|WP_013585917.1|3061158_3062304_-|sugar-ABC-transporter-permease
MSALSPARRRAGSSSSGIRRGEAAAGWLFTAPVLIILGVFLLVPVLMALWVSFSDWTGRGSPFSSNVGFVGLDNYAAVTTGGGLAERDFGTALRNNAWYVLLVVPLQTALSLFLAVLVNRAILRGRGFFRTAFYFPSVTSSVAITVLWLFLFSSSGAINEVLSWLGVNGPNWFSDPSGVVHNLLGAVGVTSGPAFLTGNTLLGVSWWDWLAGPSVAMSAFILMAVFTTSGTFMLLFIAGLQNIGGDVQEAAMMDGANGWQRFWRVTLPQLKPVLFTVLTLGLIGTWQVFDQIYTGTQGGPGKTTLTPAYLSYSAAFLSQQWGQGAAIAFVLFVIIVALTILQRFVLRDRPVSRRRLRQYEVPAAASGSGADRPRAKKGAQR
>NC_015125.1|WP_013585918.1|3062306_3063557_-|extracellular-solute-binding-protein
MTRHTPIRRARGWLAAGALLTTGALALTACGSGFNDSPGEGQASGSGKLSILIGSSGDAETKAVTDAVAAWSEKSGVPAEVQTANDLPQQLSQGFAAGSPPDLFYLAPEALAGYAANGSIAAYGDDLANKSDFYPSLVDNFTVDGKFFCAPKDFSTLALIINTDLWSAAGLTDADIPTTWDQLASVAQKLTTDGRVGLAFGAEYQRVGAFMAQAGGGLVTDGKATADSSANVEALTYVKTHLNDGSFAFASDVGAGWGGEALGTQKAAMVIEGNWITGAMKADYPDVKYKVAELPAGPGGKGTLQFTNCWGLAADSGNQEQARDLVQYLTSTDQQLAFSKAFGPMPSIQSAADAWSSANPDQTAFLAGAEYAQFPPNMAGAADVITDFNAQLESLKTGDPQALLKTAQSNLEAITK
>NC_015125.1|WP_013585919.1|3063743_3064742_+|LacI-family-DNA-binding-transcriptional-regulator
MAKAPTVDDVARVAGVSRQTVSNVVNTPDIVKEATRLRVEAAIAELGYRPHAAARRLRTRRSSTIGIHLDPYAGGISGVVLDRFVHALTERAGERDMRVLLYAARTPEEEIARLGDLLEGGEVDAVVVTGTFHGDPRTGWLTARNLPFVSFGRPWGEDDVEAPAHLWVDVDGAAGTRAATAHALARGDGRVAFLGWPGGSGTGDERERGWRETAPDGPRWVVEENVGAARDVVAAGLAADPGVTGIVCASDSLAIGAHLAVTLAGRHDVTIVGFDNTPAAEALGLSSVEQLPERVASGALDLLMGENGTVVAPRAAVAGGAHVLVEPRLVVR
>NC_015125.1|WP_013585920.1|3064917_3065691_-|IclR-family-transcriptional-regulator
MSDNPRPQVPAADQTLRILSLLARQPGPVAAQTIATTLGIPRSSTYHLLATLEQHGYVVHLPGDRRWGLGTAAFELGGGYARQQPLARLGRPLLAALSDRVGESAHLAVLAGRDVLYIVEERAPRRPALVTDVGVRLPAHLAATGRAMLSALPRPQVRALYPDATALTQRTGLGPTTPRALRELLREVRAAGYASEDGEVTPGFRSVAAPVLDHAGWPAAAVALTWPADGSARDAVALAAAASGTAAELARRIGRHA
>NC_015125.1|WP_013585921.1|3065752_3067282_+|histidine-ammonia-lyase
MSSSITVGTHPLRPDDVVAVARHDARVEVSADALRRVADTRALIEGLADDPQPHYGISTGFGALATTFIAEDRRAQLQASLIRSHAAGTGAEVEREVVRALMLLRLQTLATGRTGVRPLVVETYAALLNAGVTPIVREYGSLGCSGDLAPLSHVALAVMGEGEVRDAEGRAMPAGEALAAAGIEPVRLREKEGLALINGTDGMLGMLLLALHDLETLLTTADVAAALSVESQLGTDAVFAADLMALRPQRGQAASAANLRAFLAGSPIVASHRGPACTRVQDAYSLRCAPQVHGAARDTLAHAAMVAEQELASAVDNPVVTVDGRVESNGNFHGAPVAYVLDFLAIAVADVASMSERRTDRALDVARSNGLPPFLADEVGVDSGLMIAQYAAAGIVSELKRLAAPASVDSIPSSAMQEDHVSMGWAAARKLRRALDGLARVLAIEVMTGCRALDLRAPLQPAAATGAVRALVRTRVDGPGPDRFVSPEIEAVTDLVASGDVARVALAAA
>NC_015125.1|WP_013585922.1|3067391_3067856_-|histidine-phosphatase-family-protein
MIQLVLARHAKSDWADEGLADHDRPLNERGRRDAPQVARAVSRRGVRPEVLLSSTALRAATTAEAFAAEFEVEVTQRADLYLADPPQLLAAAREAGADEVMVVAHDPGMSELVSRLADRDVRMVTCAVAIFTWHDGTWDDVDATAPDAFELLTP
>NC_015125.1|WP_013585923.1|3067984_3068335_-|gamma-glutamylcyclotransferase
MSDDPGREFLFSYGTLLLPEVQLDTFGRRVPSDEDVLPGYRLEWTDIDDERVAQLSGMDAHPILRRTGDPRDRVFGRVLELTADELDAADEYEVSLYRRTRAVLASGREAWVYVGV
>NC_015125.1|WP_013585924.1|3068373_3069645_-|DUF445-domain-containing-protein
MARTPTAQLSPADQERRRALARMKGVALGALIGMAVIFAVAFAFQRDVTWLQYVRAAAEGGMVGALADWFAVTALFRHPLGLPIPHTAIIPRRKDEIGRQLGEFVETNFLEADVVRTKLESTPLAARAGAWLAEPAHAERLAAEGATLATSVLRALSDEDVQGLIEDLAREHLLSPDWGPSVGGWLERVVSSGAHHGAIDLAFDNIAVWLGNNREVFQGLVSQRLPAWVPSLALRLVDDTIYREAVSFVDAVRADPRHQARGAIDGYLARLADNLQHDPSTMVRLEEAKAAVFDSPRVRQLAADAWNTAKTGLLSALADPDSALRRRATAALAEVGVRLQNDETLQRRVDGWVIDAAVFVVGRYRHDIASIITDTVERWDAEETTEKIELMVGRDLQYIRLNGTIVGALAGLAIFTIAHLFWG

Crispr_ID: NC_015125_17

• CRISPR_ID: NC_015125_17
• CRISPR_location: 3252513-3252712
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_015125_17

Consensus_repeat	Method
CGTGTCGCAGGTGCCTGAGCGTGTCGCAGGTCCCTGAGCTTGTCG	CRISPRCasFinder

spacers of NC_015125_17

>17.1|3252558|34|NC_015125|CRISPRCasFinder
CGCGGTCCGGTGGCTTCGACGGGCTCAGCCACCT
>17.2|3252637|31|NC_015125|CRISPRCasFinder
CAGGTGCCTGAGCGTGTCGCAGGTCCCTGAG

CRISPR arrays and Neighbor proteins around NC_015125_17

CRISPR arrays

The CRISPR arrays of NC_015125_17

>merge|NC_015125|17|3252513-3252712|CRISPRCasFinder
CCATCCCCAGGTCCCTGAGCGTGTCGAAGGGACCGGACCTCGGCGCGCGGTCCGGTGGCTTCGACGGGCTCAGCCACCTCGTGTCGCAGGTGCCTGAGCGTGTCGCAGGTCCCTGAGCTTGTCGCAGGTGCCTGAGCGTGTCGCAGGTCCCTGAGCGTGTCGCAGGTCCCTGAGCGTGTCGCAGGTCCCTGAGCTTGTCG

>NC_015125|17|16|3252513-3252712|CRISPRCasFinder
CCATCCCCAGGTCCCTGAGCGTGTCGAAGGGACCGGACCTCGGCG	CGCGGTCCGGTGGCTTCGACGGGCTCAGCCACCT
CGTGTCGCAGGTGCCTGAGCGTGTCGCAGGTCCCTGAGCTTGTCG	CAGGTGCCTGAGCGTGTCGCAGGTCCCTGAG
CGTGTCGCAGGTCCCTGAGCGTGTCGCAGGTCCCTGAGCTTGTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013586085.1|3255154_3255673_+|DUF501-domain-containing-protein	unknown	unknown	gnl|CDD|377352
NC_015125.1|WP_013586078.1|3247536_3248394_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|375319
NC_015125.1|WP_080575435.1|3244375_3245854_+|histidine--tRNA-ligase	unknown	unknown	gnl|CDD|273080
NC_015125.1|WP_013586083.1|3252880_3254161_+|phosphopyruvate-hydratase	unknown	unknown	gnl|CDD|234617
NC_015125.1|WP_013586092.1|3263467_3263959_-|transcription-elongation-factor-GreA	unknown	unknown	gnl|CDD|234693
NC_015125.1|WP_043361501.1|3246230_3246512_+|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_080575520.1|3254677_3255097_+|septum-formation-initiator-family-protein	unknown	unknown	gnl|CDD|368217
NC_015125.1|WP_167539369.1|3251035_3251827_+|cytochrome-c-oxidase-assembly-protein	unknown	unknown	gnl|CDD|378238
NC_015125.1|WP_043363079.1|3256979_3258365_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224172
NC_015125.1|WP_013586074.1|3240888_3243561_-|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl|CDD|234570
NC_015125.1|WP_080575519.1|3243846_3244464_+|MazG-family-protein	unknown	unknown	gnl|CDD|237065
NC_015125.1|WP_013586073.1|3240122_3240722_+|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl|CDD|223735
NC_015125.1|WP_013586090.1|3260741_3261932_+|AI-2E-family-transporter	unknown	unknown	gnl|CDD|223701
NC_015125.1|WP_043361505.1|3250137_3250947_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238874
NC_015125.1|WP_013586091.1|3261928_3263158_+|threonine-ammonia-lyase	unknown	unknown	gnl|CDD|236182
NC_015125.1|WP_013586086.1|3255669_3256971_+|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|274856
NC_015125.1|WP_013586089.1|3259429_3260671_-|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225755
NC_015125.1|WP_099046917.1|3246645_3247540_+|IS5-family-transposase	unknown	unknown	gnl|CDD|379129
NC_015125.1|WP_013586079.1|3248521_3249982_+|MFS-transporter	unknown	unknown	gnl|CDD|129794
NC_015125.1|WP_013586088.1|3258822_3259392_+|LemA-family-protein	unknown	unknown	gnl|CDD|377192

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013586085.1|3255154_3255673_+|DUF501-domain-containing-protein	gnl|CDD|377352	pfam04417, DUF501, Protein of unknown function (DUF501). Family of uncharacterized bacterial proteins.	2.45514e-51
NC_015125.1|WP_013586078.1|3247536_3248394_-|helix-turn-helix-domain-containing-protein	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	8.69339e-43
NC_015125.1|WP_080575435.1|3244375_3245854_+|histidine--tRNA-ligase	gnl|CDD|273080	TIGR00442, hisS, histidyl-tRNA synthetase. This model finds a histidyl-tRNA synthetase in every completed genome. Apparent second copies from Bacillus subtilis, Synechocystis sp., and Aquifex aeolicus are slightly shorter, more closely related to each other than to other hisS proteins, and actually serve as regulatory subunits for an enzyme of histidine biosynthesis. They were excluded from the seed alignment and score much lower than do single copy histidyl-tRNA synthetases of other genomes not included in the seed alignment. These putative second copies of HisS score below the trusted cutoff. The regulatory protein kinase GCN2 of Saccharomyces cerevisiae (YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidyl-tRNA synthetase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation; these regulatory proteins are not orthologous and so score below the noise cutoff. [Protein synthesis, tRNA aminoacylation].	2.38148e-99
NC_015125.1|WP_013586083.1|3252880_3254161_+|phosphopyruvate-hydratase	gnl|CDD|234617	PRK00077, eno, enolase; Provisional.	0
NC_015125.1|WP_013586092.1|3263467_3263959_-|transcription-elongation-factor-GreA	gnl|CDD|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	7.00139e-48
NC_015125.1|WP_080575520.1|3254677_3255097_+|septum-formation-initiator-family-protein	gnl|CDD|368217	pfam04977, DivIC, Septum formation initiator. DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation. These proteins are mainly composed of an amino terminal coiled-coil.	1.40563e-15
NC_015125.1|WP_167539369.1|3251035_3251827_+|cytochrome-c-oxidase-assembly-protein	gnl|CDD|378238	pfam09678, Caa3_CtaG, Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG). Members of this family are the CtaG protein required for assembly of active cytochrome c oxidase of the caa3 type, as found in Bacillus subtilis.	4.31281e-34
NC_015125.1|WP_043363079.1|3256979_3258365_+|FAD-dependent-oxidoreductase	gnl|CDD|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.76055e-95
NC_015125.1|WP_013586074.1|3240888_3243561_-|phosphoenolpyruvate-carboxylase	gnl|CDD|234570	PRK00009, PRK00009, phosphoenolpyruvate carboxylase; Reviewed.	0
NC_015125.1|WP_080575519.1|3243846_3244464_+|MazG-family-protein	gnl|CDD|237065	PRK12334, PRK12334, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	1.32224e-67
NC_015125.1|WP_013586073.1|3240122_3240722_+|gamma-carbonic-anhydrase-family-protein	gnl|CDD|223735	COG0663, PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only].	1.45355e-39
NC_015125.1|WP_013586090.1|3260741_3261932_+|AI-2E-family-transporter	gnl|CDD|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	4.66149e-47
NC_015125.1|WP_043361505.1|3250137_3250947_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238874	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl carrier protein FeeL. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	7.8442e-49
NC_015125.1|WP_013586091.1|3261928_3263158_+|threonine-ammonia-lyase	gnl|CDD|236182	PRK08198, PRK08198, threonine dehydratase; Provisional.	0
NC_015125.1|WP_013586086.1|3255669_3256971_+|S8-family-serine-peptidase	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	6.66794e-59
NC_015125.1|WP_013586089.1|3259429_3260671_-|winged-helix-turn-helix-domain-containing-protein	gnl|CDD|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	2.49637e-98
NC_015125.1|WP_099046917.1|3246645_3247540_+|IS5-family-transposase	gnl|CDD|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	3.7703e-23
NC_015125.1|WP_013586079.1|3248521_3249982_+|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.28349e-29
NC_015125.1|WP_013586088.1|3258822_3259392_+|LemA-family-protein	gnl|CDD|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	6.05039e-77

Protein sequences

>NC_015125.1|WP_167539369.1|3251035_3251827_+|cytochrome-c-oxidase-assembly-protein
MASVTYFLGVRAARRRGENWPVRRTIGFFALGLLPYAVIELGFLGVYSSELRWAFSTRIALLIFAIPAGIAAGRPLDLVPTGVRERILASRITRIFGNAMVATVVIAAVFCLFLTPLAGILRVNPVVEASLGIVVPLVGLAMVLPMMALGAVHTGTFIAIEFLLAFVELLIDSVPGLLMRLNDNVVDLIPDATQAVSWWPSMLHDQHLAGDMIWFIAEFADLPILVILMIRWMRSDRVEAKGFDDLSDEEYDEMTRAHLRGER
>NC_015125.1|WP_043361505.1|3250137_3250947_+|SGNH/GDSL-hydrolase-family-protein
MRVRRPVTLTAASSVAVLGATAVAMRTLISRQAAIARRRIGKPLGEQALDADRVWRRKKHPGEPVELLLLGDSIAAGLGAGHRRDTLGARLAKGIAREAVRPVRLRTAAVVGSETSALALQLAELPPDYRADVAVIVVGGNDVTHRVPANRAAAQLEEAIGILRERGMPVVVGTCPDLGTLRAVPQPLRTLASRSSRQLAAAQARAAHRAGARVVGLARAVGPVFAERPDEMFSIDRFHPSALGYRRTADALLPAVLATLPTAPSSANP
>NC_015125.1|WP_013586079.1|3248521_3249982_+|MFS-transporter
MTTSAHPATGSAPVPIRPGLPDPGTAEGVPTWRYLGFLLGPGVGTFAFNAVTVILPTLRERFGAGDVALELVIAGYGIPFAVLLILGGRLGDRFGRHRLYAIGMGLFLVSAIACALAPSIETLIAARVVQGVGAALCTPQVLGTIQATSRGAARTRAIAAFGASGGIGAAVGQVAGGALAAVSFGPVEGWRAVFVVVALIAVAAIVLAPLAPRSRAHEVVAIDLVGTAALALGILAASVALTFGPAWNWSWPVAVALLVAALALWGMWRHQDAIECSGRVPLLPPSVLRLRPLQLGLIAAGLFFAGYSALLYVFPRAVEAGGLTSLQAGMALLPFAVVFAGMSLAVARIQSRLGDATLILGVSLQIVALLAMGGTLAVAWGSDIGLWLQPALVILGAGQALIFSPLTQLVVREVPVEAAGLSGGMFSTAQQLALSFGVIVIGGLVSLTGAAGRDELLAGLALDIALAVAVLIVAVALRSRARRPSR
>NC_015125.1|WP_013586078.1|3247536_3248394_-|helix-turn-helix-domain-containing-protein
MSRSDDARAEFAGFLRSRRARLRPADVGLPDGARRRVAGLRREEVAQLAGVGLTWYTWLEQGRPIAASAQVVAAIARALLLSDDERDHLFALADLPLPDREARQCVGQTHLDLLEKLLPYPAAVQTSRFDIRAYNRSYRYLFDDLDELPVERRNCAVLLFTDTAWQRAHVDLDHAQRRIAARLRAAYGRHHEEPAWQRFVAELEATSPRFAELWRLGDVGGERNAPKNLVHPRVGELHLEMSSLWIDEGLGSRVVWFAPRDDATAARLERLAAESPDEALISAVA
>NC_015125.1|WP_099046917.1|3246645_3247540_+|IS5-family-transposase
MSRFVLLSDDQFVLIADLLPGPTGRKGRPFADARTMVEGIVYRYRTGIAWRDLPRTFGPWQTVWAWHRRLAADGTWDVVLDRLVSAADTAGAVDWSVSVDSTIARAHQHATNISRVTGASSNYTNPRLEPPDHGFGRSRGGLSTKIHQLVDGHGLPLVTLVTPGQAGDSPMLLPLLAELRVTRPVGRPRTRPDRVRGDKAYSSRAIRAHLRSRGIEAVIPEPRDQQGHRKRRGSRGGRPVSYNPVDYRNRNVIERGFCRVKQWRGLATRYDKLAIVYRAAVVLNAVIAWLRHLQDTP
>NC_015125.1|WP_043361501.1|3246230_3246512_+|hypothetical-protein
MNMEAFAALWPRIAYWVLWASILAILATGMILLAVGQTVEWIPNAGNPNVYQAQTVSLVPAGGALSGIGGLAVIATLMLEAFVGPLHRRRSQH
>NC_015125.1|WP_080575435.1|3244375_3245854_+|histidine--tRNA-ligase
MPSAPCASACGPCARRCGRRRRAPKPHPIDETVRGGRPSPTVSSIPYGLGAKRGFPTRGAAGAWNNGTVASVNPPRGMRDFLPADKARRERVLAVIRERYRAHGFDEIETPVMEDYDRLHAGIGGDNEKLSFSILKRGMDAEAIRAAADDPAALADLGLRYDLTVPLARFYATNRAQLPAVFRSIQMAPVWRAERPQKGRYRQFLQCDIDIIGDASARAEAELMIASLDVLDELGLEGGSIRVNDRRVLDAMLDVFGFVPDDRPGVLITIDKLDKVGSSGVVAELRDRGAAAEAVDALAAYLDRPAAPPSFDDAGIRAALPAGIPDEVITHLVTLGETVAAARGADAPLVFDPFLVRGMGYYTGTIFELAHPSVDYSLGGGGRYDGMIGRFLGQQVPAVGFSIGFERIVDLLPDTDAAGDRSVVLVHDRDVPLAQLLALKTHLVAGGARVRVEQRPKNMKALLERSAADGYSSFAPVGVDTTVESLELRPLS
>NC_015125.1|WP_080575519.1|3243846_3244464_+|MazG-family-protein
MRTVRERCAWTQTIDHRDLVPYLVEESAEVIDAVEAGTRADLREELGDLLWQVLFHAEIAAGDPDDPFDIDDVARGLTEKMVRRHPHVFADAVASTPDEVLVHWNAAKAAEKHDRTSVLDGVSDHMPSLALAQKVVGKAAQVGVSAPHHRLADPASEAELGDALLALVQLGRERGWDAERALRERLRTLRAEVRAAEAGAETASD
>NC_015125.1|WP_013586074.1|3240888_3243561_-|phosphoenolpyruvate-carboxylase
MRELTPTEAIDLVGRFEAGQELPEQMRADVRLLGSLLGRVLQESGSPGLYDDVERLRTATIQAYTDETPEAFERAAAIADGFSIERADEVARAFTAYFHLVNLVEEHQRVRILRERGDRPSRSGTPDTIATAFERLSSEVGEETALARLQALRFHPVFTAHPTEARRRAISTSIRRLSELLSEHDDAPDGGTESRRAERRMLEEIDTLWRTAPLRREKPSPVDEVRSVMSVFDETLYTAVPRVYRRIDDILQGEHAGSRAPIVKPFVRVGSWVGGDRDGNPFVTASVTRKAAAIASEHVLLGLERTTQRVGRGLTLDAETTPPSDALVALWHRLRAADEDAAAEIAERSPDEPHRRILLLLARKIAATRTRDADLAYRDPEHLLADLRTVQDSLVAAGAARQAYGALQRLVWQVETYGFHLTELEVRQHSAVHRKVLDELRAGGARSEQTDEVLEVFRSIAYVQERFGPRAAGRYIVSFTQSAEDLANVHELASYAMGPGETLPVLDVIPLFETFADLQAAPGILAEIVSHPSFVSRLDATGRRLEVMLGYSDSSKDVGPVAANLALYEAQAKISTWAEAEGIELTLFHGRGGALGRGGGPANSAILAQPPHSVDGRFKLTEQGEVIFARYGDADIAMRHIDQVAAAVLTASSPSIERRNRGAAEAFADVAKTMDVASRERFFALVKAPGFAPWFATVTPMEELGHLALGSRPARRGLSVESLEDLRAIPWVFSWTQARINLAGWFGLGTALDAVGDEQRLRDAYEQWPLFRTMIDNVAMSLAKADERIARRYLALGDRDDLAQLVMDEMLLTRSWVERITGGGLLGNKPVLQRAVKMRSPYVDALSLLQLRALRALRDASTESETPDAEHQRLLLLSVSGVAAGLQNTG
>NC_015125.1|WP_013586073.1|3240122_3240722_+|gamma-carbonic-anhydrase-family-protein
MLFAHLGAEPRIHPDAVVAPTAVISGDVTIGAGCQILHGAVLTSEGSPIVLGENVLVMENALVRASSTHPVHVGAHTLVGPMASVAGADVGEEVFLATGTRIFNGAEIGDRSEVRINAVVHLRTILPAETVVPIRWVAVGDPLQLLSPDRHDEIWAAQKELDFPGYVFGLDRETPDLMVQLTERYGRSLARHAADRPLG
>NC_015125.1|WP_013586083.1|3252880_3254161_+|phosphopyruvate-hydratase
MALIEAVNAREILDSRGNPTVEVEVLLDDGIVQRAAVPSGASTGAFEAYELRDGDKSRYSGKGVLKAVAAVVDELGPAIEGVEASEQRIIDEILIETDGTENKSRTGANAILGVSLAVAKAAADSADLPLFRYLGGPNAHLLPVPLFNVINGGEHADNGIDFQEFFLAPIGAETYGESLRWGTEVYHVLKGELKSAGYNTGLGDEGGFAPDLPSNREGLDFLIRAIEKAGFTPGKEIAVGLDVAATEFYKDGVYTVEGKEWSVDTLVDYFADLVANFPIVTIEDALAEDDWDGWKKLTDAIGSKVQLVGDDLFVTNPKRLQQGIDLGVANSLLVKVNQIGTLSETLDAISLATRSGYTSMLSHRSGETEDTTIADLAVAVNAGQIKTGAPARSERVAKYNQLLRIEEDLGDAAVFAGRSAFPRFKG
>NC_015125.1|WP_080575520.1|3254677_3255097_+|septum-formation-initiator-family-protein
MLGLVVLGTFVLVPTVGTYMDQRQQIQALKSAVALSQSEVADLQSQRERWSDPAYITTQARERLYYTMPGEVVYLIDDDLPASAALQDQADVSGDVSQTRTDWMSQFMRSLTSAGSAQVAVPTVGVPDPTPTPDAPPAP
>NC_015125.1|WP_013586085.1|3255154_3255673_+|DUF501-domain-containing-protein
MTSTQLPPASDADLAVLQTQLGRVPRGVVGIAARCVCGNPTVVATSPRLDDGSPFPTFYYLTHPAATAAMSVLEAGHVMKEFQDELAEDDDLRAAYLAAHEAYLRDRAAYGEPEEIAGISAGGMPTRVKCLHALAGHSLAAGPGVNPIGDRALARGTWSPERCVCETPGAGG
>NC_015125.1|WP_013586086.1|3255669_3256971_+|S8-family-serine-peptidase
MRRVVAAAASLVLAVMLSGATTAPVPEDPTDSVRAGEYWLDQYGIREAWNTTRGAGQKIAIIDTGIARGPVEFNGAVVGGTDVSGAGSSDGRTPVGAVDSNHGSWVASLAASRGTGNGRGMIGVAPEAELLSISIGFGASASVPFTEQIANAMRWAVDHGATVINLSLTTNTLDWDPSWDDAFMYAFDHDVVVVVAAGNRGSGTDRVGAPATIPGVLAVGGVDPSGRASSDASTQGITIGISAPSERLLGISADGTLAQWNGTSGAAPIVAGIAALVRAAHPGMDADNVLNRLISTAKPAPGTAPGLDLLYGYGLVDASRAVSADVPSVSENPLGSLEDWIRVYRRADSEPSPTPSSAPVEIPPLPPVEGPPSASSPLLPSRDTVLYGSLPLAGATLAAIMIALGVSAAARRIRKARGSREPSRTTNQESLPS
>NC_015125.1|WP_043363079.1|3256979_3258365_+|FAD-dependent-oxidoreductase
MPRILIVGGGYAGFYTAWKLEKLLGRGEAEVTIVDPLPYMTYQPFLPEVAAGEIEPRHVVVGLRRHLKRTTVIAGKITGINHATKTATITPIVGDETWQHEYDQIVVTAGAVSRTFPIPGIAENAIGLKTIEEAVAIRDRLTSNFDKASVLPAGPERDRLLTVVVVGGGFAGIEVFAELRAYASSLLKSYPQLSFDDTHFHLIEAMGRIMPEVSQKTSEWVLKDLAKKGAFVHLDTQVKGAVDGVIELSTGEQLPSDLIIWTAGVMANPTVVRGSDLPVEERGRIRTRPDLRVGTDEEVVEGAWAAGDVSAVPDLSGGGVGGFCVPNAQHAVRQGKLMAKNIVAVLRGEQPKQYFHKNLGAVAGLGLYNGAFQSGKIALTGFIAWLAHRGYHGLAMPTWERKFRVVGDWVQNFLHGRETVNLEAVQNPRATFEEFAARPRPAAPAAEAPADEKKPEPVAAK
>NC_015125.1|WP_013586088.1|3258822_3259392_+|LemA-family-protein
MWEWLVPVLVIVGIVVIAGIYLWATYNSLVALNVRVDEAWSDITVQLKRRADLLPNLIETVKGYASHEKAVFENVTRARAETLTAESPAAAGVAEGHMQQALKSLFAVAEAYPQLQASQNFLQLQHSIVDTEDKIQASRRFYNGGVRELNTKIKVFPNNLFARQLGFSEREFFEVVDGAAIAEPPRVQF
>NC_015125.1|WP_013586089.1|3259429_3260671_-|winged-helix-turn-helix-domain-containing-protein
MTTTLRRADARRIALAAQGFARPRPETVGTRQITGALHRMRILQIDSVNVFSRSHYMPVFARLGPYDTALLDKLAFSRRPKWVESWAHVASLVSVDDWPLLQFRRDALRAKYGADAWAEANQPLLQWLRDELSARGPLRPAEIDHDARSGSRGSWWGWDDVKNGLERLWLFGEVAIAGRRGFERRYALASDVLPASALETVVPREAAIAELVRRAAVAYGVATAADLADYWRIRDRPAVMAAVHDLVDAGELIPVQVDGWQVAGRPAKAWLHRDAARPRRVDAAAILTPFDPVVWFRDRAERLFDFDYRIEIYTPAPQRRFGYYSLPVVVGDDVVGRIDLKADRASSALRVQSAWWEHGAPPDAADRVAAELVAAANWQGLERITVARWGDAADAVAGALRAERHDHPDGRST
>NC_015125.1|WP_013586090.1|3260741_3261932_+|AI-2E-family-transporter
MTGSDPEPRGSFLDALKRRTVSSDLQPPVPPALRQATAYAWRLLVIAAALGVVIWVVIQLKLLVIPLLVAILITALVWPAFSFLQRHRWPKWLAIVVTVLGTIAVISGLVWLAVWQISREFASVQERTVLAVEQFRQYLIDGPLHLSAQQIDDGLTQAGAFLQQQAELLWTGALAIGTTLGHVGTGVLLTLFILLCLLADGGGIWRWTTRLFPRVARPAVDGAGRAGWRTVKSYARTQLLVATIDAIGIGLGAFLLGVPLSIPIGVLVFLGAFIPFVGAVATGALAVFIALVYNGPLIALFMLIVVLGVQQVESHILQPILMGSAVKVHPLAVVLVVAGGAMIGGIAGALFAVPLAAFVNVVAVYLSSKAWEHEGQPLASRDLIWQTVPRERGRRS
>NC_015125.1|WP_013586091.1|3261928_3263158_+|threonine-ammonia-lyase
MNDTPTLAEFEDAAQALRGIITRTPLDESLHLTELLGVPVNLKLENLQRTGSFKIRGASHRLSRLTAEERARGVVAASAGNHAQGVALAAQQLGIPATIFMPLGVPVPKLLATRGYGAEVILEGATVETPLRLAAEFAERTGAVLIHPFDHRDIIVGQGTLGLELIEDMPDLDTIIVGIGGGGLAAGVAAAVKARAAVEGRDVRIIGVQAHNSAAYPSSLAAGYPMQVETTPTMADGIAVARPGDLPFELIRKYVDEVVTVTEDDIARALLVLLERAKQVVEPAGAVGVAAILAGKIQATGPTVTILSGGNIDPLLLQRVVAHGLSASGRYMSLRIPLPDRPGQLARVSELLAQVGANVIEVLHTRHGQGLQISEVILQLSVETRGAEHRALVIQTLEDAGFIATVVPD
>NC_015125.1|WP_013586092.1|3263467_3263959_-|transcription-elongation-factor-GreA
MSNDAQVTFLTQDAYDRLAQELEHLSTTGREEIAKRIEIAREEGDLKENGGYHAAKDEQGKQEARIRTLQQLLKDAKVGEAPESHGVVESGTVVTAVVAGGEEKFLLGNREIAANSELDVYSEASPLGAAIIGLKEGEKGSYTAPNGKEISVEIVKVETYSGQ

Crispr_ID: NC_015125_18

• CRISPR_ID: NC_015125_18
• CRISPR_location: 3431114-3431200
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_18

Consensus_repeat	Method
ACCCCGTCGGCCCGGGTCCCTGAGCT	CRISPRCasFinder

spacers of NC_015125_18

>18.1|3431140|35|NC_015125|CRISPRCasFinder
TGTCGAGGGGTGCGGTGGCTTCGGCGGGCTCAGCG

CRISPR arrays and Neighbor proteins around NC_015125_18

CRISPR arrays

The CRISPR arrays of NC_015125_18

>merge|NC_015125|18|3431114-3431200|CRISPRCasFinder
ACCCCGTCGGCCCGGGTCCCTGAGCTTGTCGAGGGGTGCGGTGGCTTCGGCGGGCTCAGCGACCCCGTCCGCCCGGGTCCCTGAGCT

>NC_015125|18|17|3431114-3431200|CRISPRCasFinder
ACCCCGTCGGCCCGGGTCCCTGAGCT	TGTCGAGGGGTGCGGTGGCTTCGGCGGGCTCAGCG
ACCCCGTCCGCCCGGGTCCCTGAGCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013586252.1|3435730_3437341_-|amidohydrolase	unknown	unknown	gnl|CDD|238625
NC_015125.1|WP_158309759.1|3439212_3440988_-|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl|CDD|349873
NC_015125.1|WP_043361554.1|3423572_3425135_+|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_193374931.1|3422352_3423597_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NC_015125.1|WP_013586246.1|3429256_3430075_+|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|366154
NC_015125.1|WP_013586257.1|3442457_3443570_+|peptide-chain-release-factor-2	unknown	unknown	gnl|CDD|234799
NC_015125.1|WP_013586242.1|3425537_3426872_-|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl|CDD|236426
NC_015125.1|WP_080575524.1|3441148_3442387_-|MFS-transporter	unknown	unknown	gnl|CDD|340883
NC_015125.1|WP_013586238.1|3420712_3421405_-|NTP-transferase-domain-containing-protein	unknown	unknown	gnl|CDD|133014
NC_015125.1|WP_013586245.1|3428642_3429239_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl|CDD|234648
NC_015125.1|WP_013586253.1|3437413_3438436_+|NADPH:quinone-reductase	unknown	unknown	gnl|CDD|176215
NC_015125.1|WP_043363140.1|3425195_3425462_+|DUF3039-domain-containing-protein	unknown	unknown	gnl|CDD|378609
NC_015125.1|WP_080575523.1|3434801_3435545_-|VTT-domain-containing-protein	unknown	unknown	gnl|CDD|182775
NC_015125.1|WP_013586247.1|3430158_3431076_+|cation-transporter	unknown	unknown	gnl|CDD|224151
NC_015125.1|WP_013586244.1|3427915_3428641_+|ribonuclease-PH	unknown	unknown	gnl|CDD|178914
NC_015125.1|WP_013586258.1|3443669_3444689_+|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl|CDD|225438
NC_015125.1|WP_013586248.1|3431221_3433699_-|ATP-dependent-DNA-ligase	unknown	unknown	gnl|CDD|236599
NC_015125.1|WP_013586250.1|3433937_3434792_+|Ku-protein	unknown	unknown	gnl|CDD|238408
NC_015125.1|WP_013586254.1|3438419_3439079_-|DUF1275-domain-containing-protein	unknown	unknown	gnl|CDD|226146
NC_015125.1|WP_013586243.1|3427060_3427879_+|glutamate-racemase	unknown	unknown	gnl|CDD|234851

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013586252.1|3435730_3437341_-|amidohydrolase	gnl|CDD|238625	cd01300, YtcJ_like, YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.	9.28078e-125
NC_015125.1|WP_158309759.1|3439212_3440988_-|M20/M25/M40-family-metallo-hydrolase	gnl|CDD|349873	cd03876, M28_SGAP_like, M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins. Peptidase family M28; Streptomyces griseus Aminopeptidase (SGAP, Leucine aminopeptidase (LAP), aminopeptidase S, Mername-AA022 peptidase) subfamily. SGAP is a di-zinc exopeptidase with high preference towards large hydrophobic amino-terminal residues, with Leu being the most efficiently cleaved. It can accommodate all except Pro and Glu residues in the P1' position. It is a monomeric (30 kDa), calcium-activated and calcium-stabilized enzyme; its activation by calcium correlates with substrate specificity and it has thermal stability only in the presence of calcium. Although SGAP contains a calcium binding site, it is not conserved in many members of this subfamily. SGAP is present in the extracellular fluid of S. griseus cultures.	9.69491e-87
NC_015125.1|WP_013586238.1|3420712_3421405_-|NTP-transferase-domain-containing-protein	gnl|CDD|133014	cd02523, PC_cytidylyltransferase, Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline. This family contains proteins similar to prokaryotic phosphocholine (P-cho) cytidylyltransferases. Phosphocholine (PC) cytidylyltransferases catalyze the transfer of a cytidine monophosphate from CTP to phosphocholine to form CDP-choline. PC is the most abundant phospholipid in eukaryotic membranes and it is also important in prokaryotic membranes. For pathogenic prokaryotes, the cell surface PC facilitates the interaction with host surface and induces attachment and invasion. In addition cell wall PC serves as scaffold for a group of choline-binding proteins that are secreted from the cells. Phosphocholine (PC) cytidylyltransferase is a key enzyme in the prokaryotic choline metabolism pathway. It has been hypothesized to consist of a choline transport system, a choline kinase, CTP:phosphocholine cytidylyltransferase, and a choline phosphotransferase that transfers P-Cho from CDP-Cho to either lipoteichoic acid or lipopolysaccharide.	6.46384e-45
NC_015125.1|WP_193374931.1|3422352_3423597_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.4826e-81
NC_015125.1|WP_013586246.1|3429256_3430075_+|glycosyltransferase-family-2-protein	gnl|CDD|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	7.43787e-29
NC_015125.1|WP_013586257.1|3442457_3443570_+|peptide-chain-release-factor-2	gnl|CDD|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_015125.1|WP_013586242.1|3425537_3426872_-|nicotinate-phosphoribosyltransferase	gnl|CDD|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NC_015125.1|WP_080575524.1|3441148_3442387_-|MFS-transporter	gnl|CDD|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.33857e-30
NC_015125.1|WP_013586258.1|3443669_3444689_+|cell-division-ATP-binding-protein-FtsE	gnl|CDD|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	2.39137e-110
NC_015125.1|WP_013586245.1|3428642_3429239_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl|CDD|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	1.70102e-96
NC_015125.1|WP_013586253.1|3437413_3438436_+|NADPH:quinone-reductase	gnl|CDD|176215	cd08253, zeta_crystallin, Zeta-crystallin with NADP-dependent quinone reductase activity (QOR). Zeta-crystallin is a eye lens protein with NADP-dependent quinone reductase activity (QOR). It has been cited as a structural component in mammalian eyes, but also has homology to quinone reductases in unrelated species. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.22098e-117
NC_015125.1|WP_043363140.1|3425195_3425462_+|DUF3039-domain-containing-protein	gnl|CDD|378609	pfam11238, DUF3039, Protein of unknown function (DUF3039). This family of proteins with unknown function appears to be restricted to Actinobacteria.	4.12348e-36
NC_015125.1|WP_080575523.1|3434801_3435545_-|VTT-domain-containing-protein	gnl|CDD|182775	PRK10847, PRK10847, DedA family protein.	1.54316e-40
NC_015125.1|WP_013586247.1|3430158_3431076_+|cation-transporter	gnl|CDD|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.15553e-86
NC_015125.1|WP_013586244.1|3427915_3428641_+|ribonuclease-PH	gnl|CDD|178914	PRK00173, rph, ribonuclease PH; Reviewed.	3.45418e-160
NC_015125.1|WP_013586248.1|3431221_3433699_-|ATP-dependent-DNA-ligase	gnl|CDD|236599	PRK09632, PRK09632, ATP-dependent DNA ligase; Reviewed.	0
NC_015125.1|WP_013586250.1|3433937_3434792_+|Ku-protein	gnl|CDD|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	5.8191e-112
NC_015125.1|WP_013586254.1|3438419_3439079_-|DUF1275-domain-containing-protein	gnl|CDD|226146	COG3619, COG3619, Predicted membrane protein [Function unknown].	9.44463e-23
NC_015125.1|WP_013586243.1|3427060_3427879_+|glutamate-racemase	gnl|CDD|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	3.9292e-126

Protein sequences

>NC_015125.1|WP_013586247.1|3430158_3431076_+|cation-transporter
MHDHAPAGGIRDASNRRLLATALTLTASVMVVQIIGAILSGSLALLADAAHMFTDAAALVVALIATAIASRPADDRRTFGYQRAEVLGALANGVILIVLCAWVGIEAVQRLLAPAEAEVQGGLMLVVAAVGMVANAISMWLLGRAQKRSINVRGAYLEVLGDLVGSIAVIIAAIVIVTTGFTQADAIASLLIAVLIVPRAIGLLREVVVVLTESAPVDVHVAEIRQHLRDTDGVVDVHDVHVWQLTRGAPVFSAHVIVEDEALIDGRAARILESLQGCLADHFDVEHSTFQLEPAGHVEHDSRHA
>NC_015125.1|WP_013586246.1|3429256_3430075_+|glycosyltransferase-family-2-protein
MKPLPAVSIIVPAFNEEAVIAQCLDAIVRQTVPAAEVLVVDNRSTDATRAVVERFIAEHPGAGIRLLRQDVRQGLVPTRNLGMDAAVGDVLGRIDADTAIKPDWVAQVSRVFASGEVDAASGPVEYYDLPLRAIGQQIDDAFRRLQVRLAGDFVFLFGSNMAVRADAWRDVREHLCEDEADIMHEDLDIAVHLALAGRRIGYFSNMVAGIGARRLDDRPRDFRRYIDRFENTYSAHGIRDMRLRAPMAIFLGVYPALHAHRRIQAQLAGLRR
>NC_015125.1|WP_013586245.1|3428642_3429239_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MARVVLATHNAHKVEEFQAIVAAVRPDLEVVGYDGPEPVEDGVTFAANALIKARAAAAHTGLPALADDSGIAVDVLGGSPGVFSAYWAGHKKDSTANLELLLDQLSDVADPHRTAQFVSVIALVTPDGREDTVEGRWPGRLATAPGGTGGFGYDPIFVPEGQTPGEERTVGQWSAEEKNAESHRARAFRHLVPLLRQL
>NC_015125.1|WP_013586244.1|3427915_3428641_+|ribonuclease-PH
MTRKDGRTTDQLRPVTIERGWSAHAEGSALITFGGTKVLCTASFTNGVPRWLTGKGKGWVTAEYAMLPRATNSRNDRESIKGKVGGRTHEISRLIGRALRAVVDTKALGENTIVIDCDVLQADGGTRTAAITGAYVALADAIAWGREKKFIAQRSEVLIDSVSAVSVGIIDGEPMLDLAYVEDVRAETDMNVVVTGRGLFVEVQGTAEGAPFDKAELDRLLDLAVNGCAELRGIQTAALEG
>NC_015125.1|WP_013586243.1|3427060_3427879_+|glutamate-racemase
MDDAPIGIFDSGVGGLTVARAVSQQLPRESILYIGDTARSPYGPKPIADVRRYALEVLDTLVEQGVKMLVIACNTASAAMLRDARERYDVPVVEVIGPAVRTAMSTTRNGRIGVIGTVGTIGSRAYQDMLEVNENLTVFAEACPRFVEFVEAGVTDSPEVLATAEQYLAPLRHAGVDTLVLGCTHYPFLEGAISYVMGPDVSLVSSDSETAKDVYRQLVSRDLLAGPDATPRHRYEATGSSADDFLRLAHRLMGREVREVQLVQTGAIDLPR
>NC_015125.1|WP_013586242.1|3425537_3426872_-|nicotinate-phosphoribosyltransferase
MTRSTALLTDRYELTMLDAALRDGTAERRCVFEVFGRRLSGGRRFGVVAGTGRLLEAIQDFRFGDGELRYLRDNRIVDATTLDHLADYRFTGSVTGYREGEVYFPGSPLLTIEGTFADAVVLETLALSILNYDSAVATAAARMSVAAGDRPLAEMGSRRASEGAAVAAARAAYIAGFSATSNLEAGRRWGVPTMGTAAHAWTLLHDSEEEAFRSQIDALGTGTTLLIDTYDIAEGVRTAVRVAGPELGGVRIDSGDLPIVAGEVRALLDELGATNTRITVTSDLDEYALAALAASPVDAYGVGTSVSTGSGVPTAGLVFKLVAREAADGSWVGVAKASAQKASHGGRKAAFRTLDGGTATSELIIVSDGFEELSTAAEHPDARALQATLMIDGEADAAALGPAGVEAARAHHARVREELPMRALALSKADPALATEYREATPAR
>NC_015125.1|WP_043363140.1|3425195_3425462_+|DUF3039-domain-containing-protein
MSTPLDSPDSGGLATLDRELEELIREENIEPGDHERFSHYVKKDKILESALTGKPVRALCGKKWTPGRDPEKFPVCPQCKEIYESLTK
>NC_015125.1|WP_043361554.1|3423572_3425135_+|hypothetical-protein
MVAHVLRLRLAMMLGALRGDRDDVLRRVVGLVVLIAGTIFAAVNASGLGEVDRLTAGIVTVLAGSAITLGFAVGPPVTASVDPLDPRRFAVVGPEPRPLAGALLLAGFLSVPVLAVLVLAISVAVAWSEQGVSVFASVASIVLGLTTCVLLARVSMALGTLVKRPRQSRELAGVYLVAVLVVVVPVAVFLGSLEWRGTVPTQLVSAAEVLAWTPVGAAWGIALAPTPGAAVGSAVVAVATVAVLAALWFVLVRILLTTTPRPVAVRERGGLGWFALLPGTPGGAVAARSLSYWLRDRRYLVNIVIVPIAAVLSMVPLVVAGVPIEVAALLPVPIMALFFGWLPHNDLAYDSTALWMHIASGVRGLSDRIGRLVPVLLIGLPILAVSIPLAIVAHGRWAFLPVLIGVCAALFLSGLGLSSISSVLAPYPVSRPGDSPFQQPQRTGSGGVLAQGLVMLGSLLAASPALWFAGHALASDSEDAVVALWAGLAAGVIVLVVGVAVGAAVFERRGTRLMEFAEAT
>NC_015125.1|WP_193374931.1|3422352_3423597_+|ATP-binding-cassette-domain-containing-protein
MVEDLTPPDAAVEEPAVEEPAVEPVEDLTPPDAAVEEPAVEELAVEAPAVEGESGAADSPAEVRDDEPVEDAASVEDPAPVEGATPVEDAASGEDATPVEDTALAQDAAPLEDPTPADAPVEESPVEADADAPSEETAATTAGAAIGAAAVEGKTSAHADDATPALTLRNVTKTFGELRAVDGIDLTIPAGSFYGLVGPNGAGKTTTLSIIAGLLRADGGTVSINGVDAAKNARAAKKMIGVLPDRLRTFDRLTGRQLLSYYGALRGLPAGLVESRSADLARAFDLVDALARPVSDYSAGMTKKVMLAGAMIHSPRLLVLDEPFEAVDPVSSAVILDILGAYVAHGGTVILSSHGMELVERVCSRVAVIVSGQVLAEGTVDEVRGEASLEQRFLELAGGLGDVEGLEWLHTFSG
>NC_015125.1|WP_013586238.1|3420712_3421405_-|NTP-transferase-domain-containing-protein
MTVQIVILAAGMGSRLGRSLPKPLTPLADGRSIMQQQHDNIRAAFGRDARVTTVVGYRAETIVDAFPTADYVYNDRYDQTNTSKSLLRALAKTGRSGVLWMNGDVVFDPRVLGRAAELIDEDRSFVTVDTASVGDEEVKYTVDAEGFVKELSKVVDDGVGEAVGINYISSRDKKALMRQLQRVADQDYFERGIELAIIHDGVRVEPLDISDLYAVEVDFAEDLERANLFV
>NC_015125.1|WP_013586248.1|3431221_3433699_-|ATP-dependent-DNA-ligase
MVEQTVQIGGRRLRLSNLDKVLYPETGTTKGEVIDYYSRVAARLLPHVADRPVTRKRWPDGVGTADAPGEPFFAKALEPGAPAWVRRFPIDHSSGAKDYPLVDDLPTLVSLAQVASLELHVPQWRFSPDGERQNPDRLVLDLDPGPGVGLVECAEVARWARAILRDIGLDPLPVTSGSKGIHLYAHLDGKQSSEAASAIAKELARAIEADHPDLVVSQMSKAARPGKVFIDWSQNNGSKTTIAPYSLRGRAQPTVAAPRTWEELDDPALRHLLFTDVLERTGDPLAAVERETGPLRAYISKRTAGRTPEPVPEAPHGEPAPEGLPRFVIQEHHASRLHWDLRLEHGGVLVSWAVPKGIPSTTAKNSLAVMTEDHPMQYLDFTGEIPRGEYGAGIMTVWDTGTYELEKWRDDEVIATLQGRDDGPLGRVRVALIRTEGRGEKSQWLLHRMKTDAEGRPQADGAPVVALDHGRVGRDPEPRGAAAGHADGDVDAPDGSRRGAPSPADVRPMLATSATPGLARAAAGRWGQAWVEMKWDGIRGIGLWDGRRLRLRSRNGNDLTAAYPELTTVDLGLGPEPAIIDGEIVALDPQGRPSFPLLQKRMNLAQPREIEREARRTPVHLYLFDVLSVGDRDVSPLPLAERRGILESLAQKATAPVVIPPVFDDVDAAVATSGRFGLEGVVVKDPRSPYRRGERSEQWLKVKHSRTQEVVVGGVRPGKGNRAGTIGSLLVGVPDPDGLRYAGRVGSGFSEQTLARLSELLAPLGSDADPFVGVPAADARDAIWVRPELVAEVEFAEFTPDGILRQARWRGLRPDKDPSEVVREG
>NC_015125.1|WP_013586250.1|3433937_3434792_+|Ku-protein
MRSIWKGALTFGLVNVPVKVYSATEDHDVSLHQVHNADGGRIRYQRICEIDGEVVPYSDIDKAYDDGEQTVVLTKDDLASLPSERSREIEVVEFVPSDQVDLLTLDKAYYLEPDSSSPKAYVLLRKTLEQTDRTAIVRFSLRQKTRLAALRVRDEVLVLQTLLWADEVREAAFPALDESVRISAKELEMSASLVESFSKDFDPEEFTDEYQAELRTLIDAKLEQGDAIDTDATFGTQEEEDGGEVIDLMEALRASVERSRAARAEKDEPAKKKASAKKKSSKAS
>NC_015125.1|WP_080575523.1|3434801_3435545_-|VTT-domain-containing-protein
MHPTALLPWLDPATIITNSQPWALLVVCFIIFAETGLLIGFLLPGDTLLIMAGLLSHSTPAAPNGVFGINAWWVALAIGVAAFIGGEVGYYIGHKAGPSIFERKDSGLFSRKNVERTNAFFVRFGGLTVILARFVPVVRTFAPIAAGVGHMPWRKYTLYNFIGAVLWGIGLTMLGYAVGYIPFIRDIVTEYIDVILLAAVAGTAIFIGIHYLRERSAAKREGAVTHAEAEALTLDPQTLEDGDKPAR
>NC_015125.1|WP_013586252.1|3435730_3437341_-|amidohydrolase
MSSLLVANGILFSAGAMIDGDAVGIRDGRIVATGTRREVRTILGTVDDEVDARGGLVTPGFVDAHIHLGGGAVDALRCDLAGADSLAEIDRRVRAFAAGSTASWIVGGGWDPTLFPHGGPTAAHLDELVPDRPALFLDADHHGAWVNSAALRAAGIDADTPDPFDGRIERSTDGTPSGALREGAMQLVSPLVPPSATADVARALRTIARDVVAAGITGWQEAALGLYAGYPDFSDAYRELSTTGNLVGRATGAIWVPRDLTADTIDAFVADCVERARANTTAGFPTRTAKLMLDGIIETRTAHVCTPYPDGSHGLAYFEPAVVQKLVPALNAAGISVHVHALADAAVRDALDGFAAVPADVRAGVRNHIAHLELVTPSDVPRFAELGVTANCQPYWACRNDLVRDVTLPLLGKERADSLYPFADLRAAGATLAMGSDWPVSTYDPWLGIHVAVTRRPPGEPDAEPLGAAQALPLGVALDAYTRGSADLLGLGSGTLTPGASADLAIADRDPFTGPADGIHETRNAATIVGGELFGG
>NC_015125.1|WP_013586253.1|3437413_3438436_+|NADPH:quinone-reductase
MRAITYSQTGGSSVLTLGERPVPEPGPGDVRVRIAVSGVNPTDWKAREGGRPFSFPEVTPNQDGAGIVDAVGPGVTSVSAGQRVWVYLAQHERPTGTAAEYAVIPAGRAVPLADDASFALGASLGVPAMTAHRALTVHEDGPSRLAPGALAGRTVLVQGGAGAVGHAAIQLAVWAGATVIATVSSDEKEALARAAGAHHVLQYPSETLADGIRDLAPNGVEHIVEVAIADNAALDVEVIANHGSIGYYADNGGDSFTAAVRASFAKNVRWQGLLLYTVGETALTAAAEDVSAAVADGALPVGDEAGLPLTWFPLAETAAAHDAVADGTTGKVLIRVSDED
>NC_015125.1|WP_013586254.1|3438419_3439079_-|DUF1275-domain-containing-protein
MKDVDREALALSAALAAVAGFVDAIGFLDTGGLFVSFMSGNSTQGAVGLLDGSPQVALVSAGIIAAFVIGVTAGATVSMRAARARAWVVAGSAAGVAATAALALGGGSTTWRVGVLAAAMGALNTLFLAEGRARVAITYATGTLVSLGLGLAALLTGGSRTAWRRPLLLWSSLVTGAVIGGLAHRWGSPIALGIAALALAGAAAVIALRGRGSAVSPRR
>NC_015125.1|WP_158309759.1|3439212_3440988_-|M20/M25/M40-family-metallo-hydrolase
MPRNTLLPPPRRVRRASAIAATSALVGGALMIAPAAFAAPDAEVPNDLGLTGADVMTHLTELSAISESFADEGYRSWNGPGYEAAAQYAEKVLADTGAFTVTRHAFDVPYSEFGVASLVVDGTVYTGSHFDNSEGTDGDVTAPLALPVSEDGGFLGCAASDYAEVPAGSIVLVQRGICSFEEKIGFASDAGAAAVFVYNNERPPEENTAPEDQLTNVTSGPRNEEDSPAATLPQASGDAIEALITAAPDDAPVEGTATIEKQFLVGTSFNIIADSTAGDPEDTVVIGAHLDGVAEGPGVNDNASGSAAVLALAEKIAASEVPNDKRIRLALWGAEEIGLLGSTAYVNDLVANDAAEWDRISSYLNYDMIGSENFTVGVYDADRSTFPAEGVNIPEGSEAIEKIYTDYFDTIEQPWIDTEYSGRSDYQAFIDNGVPSGGLFSGGDDIKTEEQVEMFGGTPGVFMDRNYHTVNDTLANINRDSVDIFAPAIGHAAAALAWTAAVEPSPEPTVEPTGEPTLEPTAEPTTEPTAEPTTQPSPSPSTTTGPGPRDNLAKTGSNAEGSALPAIGAGMLVLGALIAAGTVIARRRPQE
>NC_015125.1|WP_080575524.1|3441148_3442387_-|MFS-transporter
MIYGPTLLFAIGEGAVIPLIPVIANRLGADVALAALVAAALVVGQLCGNIPAGWAVARFGERITMGVAGIVILGGLVGVVFAGTLAIFAAAVFLIGFCAASFALARHSFMTTRVPLHFRARALSLLGGTFRLGMFVGPFISAALLGIFGDETASILFFAVCQVATILLVFLGPDPEKAVPVTGVAAGEPAEGASREAEDTGEPVSGAIPTAERAGVFRTMWRFRAVLARLGLAAASLSAVRSARQVVLPLWGVSLGLDASTIAVVVGVSGAIDFALFYASGQVMDRFGRLWAALPAMVLMGAGFLALAFTHDLTSAAMWFAMFAAVLGVGNGLSSGILLTLGADLAPPDEPAAFLGSWRTLTDAGGAVAPVLISALTATVSLSGAVGAMGVIAALGAFGFVRWVPRYVPRAR
>NC_015125.1|WP_013586257.1|3442457_3443570_+|peptide-chain-release-factor-2
MLELDLTADIQALRSTFADIQAVVDVDALKADIDRLSEEAGAPDLWDDVDNAQKVTSRLSHRQAELKRITEIEQRLDDLEVLVELAIEMDDEDSADEARRELASLKDVIGQLEVQTLLDGEYDSRSAVVTIRSGAGGDDATDFAEMLLRMYLRWAERHKYPVKVMDTSYAEGAGIKSATFEVDVPYAYGTLSVEAGTHRLARISPFGGADKRQTSFAAVEVIPVMEEAVEVEVPEGDIRVDVFRSSGPGGQSVNTTDSAVRITHIPTGLVVSMQNEKSQIQNRAAAMRVLQTRLLLLKREEEAAKKKELAGTITASWGDQMRSYFLYGQQLVKDLRTGYEVGNPAVVFDGDLDGLIAAGIRWRKRKDDDD
>NC_015125.1|WP_013586258.1|3443669_3444689_+|cell-division-ATP-binding-protein-FtsE
MIRFENVTKRYRGTTKPALNAVDFEVQRGEFVFLVGASGSGKSSCLQLILRAETPSDGRVVVLGRDLRTLSNRKVPYFRRHIGSVFQDFRLLPNKTVHQNVAFTLQVTGASRGFVQQAVPEVLALVGLDGKEKRLPHELSGGEQQRVAIARALVNRPQVLLADEPTGNLDPGTSIDIMRLLARINAGGTTVVMATHEAGFVDQMQRRVIELRGGEMVRDERHGGYGDRSGLPVLAPEVEKGAAAVAALTAVLEVQREVTSITGPVEPLRGPEGSEQVSAAPVEPESPSVTTSPAAERREPATNTRSIPVSTPEVDALGLADRLGLAEKKDRDDEVGPTS

Crispr_ID: NC_015125_19

• CRISPR_ID: NC_015125_19
• CRISPR_location: 3433797-3433881
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015125_19

Consensus_repeat	Method
GGTCCCTGAGCCTGTCGAAGGGACCGGGAG	CRISPRCasFinder

spacers of NC_015125_19

>19.1|3433827|25|NC_015125|CRISPRCasFinder
GCGGGCTCAGCCACCTCGCGCGTGA

CRISPR arrays and Neighbor proteins around NC_015125_19

CRISPR arrays

The CRISPR arrays of NC_015125_19

>merge|NC_015125|19|3433797-3433881|CRISPRCasFinder
GGTCCCTGAGCCTGTCGAAGGGACCGGGAGGCGGGCTCAGCCACCTCGCGCGTGAGGTCCCTGAGCTTGTCGAAGGGACCGGGAG

>NC_015125|19|18|3433797-3433881|CRISPRCasFinder
GGTCCCTGAGCCTGTCGAAGGGACCGGGAG	GCGGGCTCAGCCACCTCGCGCGTGA
GGTCCCTGAGCTTGTCGAAGGGACCGGGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015125.1|WP_013586252.1|3435730_3437341_-|amidohydrolase	unknown	unknown	gnl|CDD|238625
NC_015125.1|WP_158309759.1|3439212_3440988_-|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl|CDD|349873
NC_015125.1|WP_043361554.1|3423572_3425135_+|hypothetical-protein	unknown	unknown	unknown
NC_015125.1|WP_193374931.1|3422352_3423597_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NC_015125.1|WP_013586246.1|3429256_3430075_+|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|366154
NC_015125.1|WP_013586257.1|3442457_3443570_+|peptide-chain-release-factor-2	unknown	unknown	gnl|CDD|234799
NC_015125.1|WP_013586242.1|3425537_3426872_-|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl|CDD|236426
NC_015125.1|WP_080575524.1|3441148_3442387_-|MFS-transporter	unknown	unknown	gnl|CDD|340883
NC_015125.1|WP_013586258.1|3443669_3444689_+|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl|CDD|225438
NC_015125.1|WP_013586245.1|3428642_3429239_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl|CDD|234648
NC_015125.1|WP_013586253.1|3437413_3438436_+|NADPH:quinone-reductase	unknown	unknown	gnl|CDD|176215
NC_015125.1|WP_043363140.1|3425195_3425462_+|DUF3039-domain-containing-protein	unknown	unknown	gnl|CDD|378609
NC_015125.1|WP_013586259.1|3444685_3445603_+|FtsX-like-permease-family-protein	unknown	unknown	gnl|CDD|225088
NC_015125.1|WP_080575523.1|3434801_3435545_-|VTT-domain-containing-protein	unknown	unknown	gnl|CDD|182775
NC_015125.1|WP_013586247.1|3430158_3431076_+|cation-transporter	unknown	unknown	gnl|CDD|224151
NC_015125.1|WP_013586244.1|3427915_3428641_+|ribonuclease-PH	unknown	unknown	gnl|CDD|178914
NC_015125.1|WP_013586248.1|3431221_3433699_-|ATP-dependent-DNA-ligase	unknown	unknown	gnl|CDD|236599
NC_015125.1|WP_013586250.1|3433937_3434792_+|Ku-protein	unknown	unknown	gnl|CDD|238408
NC_015125.1|WP_013586254.1|3438419_3439079_-|DUF1275-domain-containing-protein	unknown	unknown	gnl|CDD|226146
NC_015125.1|WP_013586243.1|3427060_3427879_+|glutamate-racemase	unknown	unknown	gnl|CDD|234851

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015125.1|WP_013586252.1|3435730_3437341_-|amidohydrolase	gnl|CDD|238625	cd01300, YtcJ_like, YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.	9.28078e-125
NC_015125.1|WP_158309759.1|3439212_3440988_-|M20/M25/M40-family-metallo-hydrolase	gnl|CDD|349873	cd03876, M28_SGAP_like, M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins. Peptidase family M28; Streptomyces griseus Aminopeptidase (SGAP, Leucine aminopeptidase (LAP), aminopeptidase S, Mername-AA022 peptidase) subfamily. SGAP is a di-zinc exopeptidase with high preference towards large hydrophobic amino-terminal residues, with Leu being the most efficiently cleaved. It can accommodate all except Pro and Glu residues in the P1' position. It is a monomeric (30 kDa), calcium-activated and calcium-stabilized enzyme; its activation by calcium correlates with substrate specificity and it has thermal stability only in the presence of calcium. Although SGAP contains a calcium binding site, it is not conserved in many members of this subfamily. SGAP is present in the extracellular fluid of S. griseus cultures.	9.69491e-87
NC_015125.1|WP_013586258.1|3443669_3444689_+|cell-division-ATP-binding-protein-FtsE	gnl|CDD|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	2.39137e-110
NC_015125.1|WP_193374931.1|3422352_3423597_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.4826e-81
NC_015125.1|WP_013586246.1|3429256_3430075_+|glycosyltransferase-family-2-protein	gnl|CDD|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	7.43787e-29
NC_015125.1|WP_013586257.1|3442457_3443570_+|peptide-chain-release-factor-2	gnl|CDD|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_015125.1|WP_013586242.1|3425537_3426872_-|nicotinate-phosphoribosyltransferase	gnl|CDD|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NC_015125.1|WP_080575524.1|3441148_3442387_-|MFS-transporter	gnl|CDD|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.33857e-30
NC_015125.1|WP_013586245.1|3428642_3429239_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl|CDD|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	1.70102e-96
NC_015125.1|WP_013586253.1|3437413_3438436_+|NADPH:quinone-reductase	gnl|CDD|176215	cd08253, zeta_crystallin, Zeta-crystallin with NADP-dependent quinone reductase activity (QOR). Zeta-crystallin is a eye lens protein with NADP-dependent quinone reductase activity (QOR). It has been cited as a structural component in mammalian eyes, but also has homology to quinone reductases in unrelated species. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.22098e-117
NC_015125.1|WP_043363140.1|3425195_3425462_+|DUF3039-domain-containing-protein	gnl|CDD|378609	pfam11238, DUF3039, Protein of unknown function (DUF3039). This family of proteins with unknown function appears to be restricted to Actinobacteria.	4.12348e-36
NC_015125.1|WP_013586259.1|3444685_3445603_+|FtsX-like-permease-family-protein	gnl|CDD|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	1.42497e-40
NC_015125.1|WP_080575523.1|3434801_3435545_-|VTT-domain-containing-protein	gnl|CDD|182775	PRK10847, PRK10847, DedA family protein.	1.54316e-40
NC_015125.1|WP_013586247.1|3430158_3431076_+|cation-transporter	gnl|CDD|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.15553e-86
NC_015125.1|WP_013586244.1|3427915_3428641_+|ribonuclease-PH	gnl|CDD|178914	PRK00173, rph, ribonuclease PH; Reviewed.	3.45418e-160
NC_015125.1|WP_013586248.1|3431221_3433699_-|ATP-dependent-DNA-ligase	gnl|CDD|236599	PRK09632, PRK09632, ATP-dependent DNA ligase; Reviewed.	0
NC_015125.1|WP_013586250.1|3433937_3434792_+|Ku-protein	gnl|CDD|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	5.8191e-112
NC_015125.1|WP_013586254.1|3438419_3439079_-|DUF1275-domain-containing-protein	gnl|CDD|226146	COG3619, COG3619, Predicted membrane protein [Function unknown].	9.44463e-23
NC_015125.1|WP_013586243.1|3427060_3427879_+|glutamate-racemase	gnl|CDD|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	3.9292e-126

Protein sequences

>NC_015125.1|WP_013586248.1|3431221_3433699_-|ATP-dependent-DNA-ligase
MVEQTVQIGGRRLRLSNLDKVLYPETGTTKGEVIDYYSRVAARLLPHVADRPVTRKRWPDGVGTADAPGEPFFAKALEPGAPAWVRRFPIDHSSGAKDYPLVDDLPTLVSLAQVASLELHVPQWRFSPDGERQNPDRLVLDLDPGPGVGLVECAEVARWARAILRDIGLDPLPVTSGSKGIHLYAHLDGKQSSEAASAIAKELARAIEADHPDLVVSQMSKAARPGKVFIDWSQNNGSKTTIAPYSLRGRAQPTVAAPRTWEELDDPALRHLLFTDVLERTGDPLAAVERETGPLRAYISKRTAGRTPEPVPEAPHGEPAPEGLPRFVIQEHHASRLHWDLRLEHGGVLVSWAVPKGIPSTTAKNSLAVMTEDHPMQYLDFTGEIPRGEYGAGIMTVWDTGTYELEKWRDDEVIATLQGRDDGPLGRVRVALIRTEGRGEKSQWLLHRMKTDAEGRPQADGAPVVALDHGRVGRDPEPRGAAAGHADGDVDAPDGSRRGAPSPADVRPMLATSATPGLARAAAGRWGQAWVEMKWDGIRGIGLWDGRRLRLRSRNGNDLTAAYPELTTVDLGLGPEPAIIDGEIVALDPQGRPSFPLLQKRMNLAQPREIEREARRTPVHLYLFDVLSVGDRDVSPLPLAERRGILESLAQKATAPVVIPPVFDDVDAAVATSGRFGLEGVVVKDPRSPYRRGERSEQWLKVKHSRTQEVVVGGVRPGKGNRAGTIGSLLVGVPDPDGLRYAGRVGSGFSEQTLARLSELLAPLGSDADPFVGVPAADARDAIWVRPELVAEVEFAEFTPDGILRQARWRGLRPDKDPSEVVREG
>NC_015125.1|WP_013586247.1|3430158_3431076_+|cation-transporter
MHDHAPAGGIRDASNRRLLATALTLTASVMVVQIIGAILSGSLALLADAAHMFTDAAALVVALIATAIASRPADDRRTFGYQRAEVLGALANGVILIVLCAWVGIEAVQRLLAPAEAEVQGGLMLVVAAVGMVANAISMWLLGRAQKRSINVRGAYLEVLGDLVGSIAVIIAAIVIVTTGFTQADAIASLLIAVLIVPRAIGLLREVVVVLTESAPVDVHVAEIRQHLRDTDGVVDVHDVHVWQLTRGAPVFSAHVIVEDEALIDGRAARILESLQGCLADHFDVEHSTFQLEPAGHVEHDSRHA
>NC_015125.1|WP_013586246.1|3429256_3430075_+|glycosyltransferase-family-2-protein
MKPLPAVSIIVPAFNEEAVIAQCLDAIVRQTVPAAEVLVVDNRSTDATRAVVERFIAEHPGAGIRLLRQDVRQGLVPTRNLGMDAAVGDVLGRIDADTAIKPDWVAQVSRVFASGEVDAASGPVEYYDLPLRAIGQQIDDAFRRLQVRLAGDFVFLFGSNMAVRADAWRDVREHLCEDEADIMHEDLDIAVHLALAGRRIGYFSNMVAGIGARRLDDRPRDFRRYIDRFENTYSAHGIRDMRLRAPMAIFLGVYPALHAHRRIQAQLAGLRR
>NC_015125.1|WP_013586245.1|3428642_3429239_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MARVVLATHNAHKVEEFQAIVAAVRPDLEVVGYDGPEPVEDGVTFAANALIKARAAAAHTGLPALADDSGIAVDVLGGSPGVFSAYWAGHKKDSTANLELLLDQLSDVADPHRTAQFVSVIALVTPDGREDTVEGRWPGRLATAPGGTGGFGYDPIFVPEGQTPGEERTVGQWSAEEKNAESHRARAFRHLVPLLRQL
>NC_015125.1|WP_013586244.1|3427915_3428641_+|ribonuclease-PH
MTRKDGRTTDQLRPVTIERGWSAHAEGSALITFGGTKVLCTASFTNGVPRWLTGKGKGWVTAEYAMLPRATNSRNDRESIKGKVGGRTHEISRLIGRALRAVVDTKALGENTIVIDCDVLQADGGTRTAAITGAYVALADAIAWGREKKFIAQRSEVLIDSVSAVSVGIIDGEPMLDLAYVEDVRAETDMNVVVTGRGLFVEVQGTAEGAPFDKAELDRLLDLAVNGCAELRGIQTAALEG
>NC_015125.1|WP_013586243.1|3427060_3427879_+|glutamate-racemase
MDDAPIGIFDSGVGGLTVARAVSQQLPRESILYIGDTARSPYGPKPIADVRRYALEVLDTLVEQGVKMLVIACNTASAAMLRDARERYDVPVVEVIGPAVRTAMSTTRNGRIGVIGTVGTIGSRAYQDMLEVNENLTVFAEACPRFVEFVEAGVTDSPEVLATAEQYLAPLRHAGVDTLVLGCTHYPFLEGAISYVMGPDVSLVSSDSETAKDVYRQLVSRDLLAGPDATPRHRYEATGSSADDFLRLAHRLMGREVREVQLVQTGAIDLPR
>NC_015125.1|WP_013586242.1|3425537_3426872_-|nicotinate-phosphoribosyltransferase
MTRSTALLTDRYELTMLDAALRDGTAERRCVFEVFGRRLSGGRRFGVVAGTGRLLEAIQDFRFGDGELRYLRDNRIVDATTLDHLADYRFTGSVTGYREGEVYFPGSPLLTIEGTFADAVVLETLALSILNYDSAVATAAARMSVAAGDRPLAEMGSRRASEGAAVAAARAAYIAGFSATSNLEAGRRWGVPTMGTAAHAWTLLHDSEEEAFRSQIDALGTGTTLLIDTYDIAEGVRTAVRVAGPELGGVRIDSGDLPIVAGEVRALLDELGATNTRITVTSDLDEYALAALAASPVDAYGVGTSVSTGSGVPTAGLVFKLVAREAADGSWVGVAKASAQKASHGGRKAAFRTLDGGTATSELIIVSDGFEELSTAAEHPDARALQATLMIDGEADAAALGPAGVEAARAHHARVREELPMRALALSKADPALATEYREATPAR
>NC_015125.1|WP_043363140.1|3425195_3425462_+|DUF3039-domain-containing-protein
MSTPLDSPDSGGLATLDRELEELIREENIEPGDHERFSHYVKKDKILESALTGKPVRALCGKKWTPGRDPEKFPVCPQCKEIYESLTK
>NC_015125.1|WP_043361554.1|3423572_3425135_+|hypothetical-protein
MVAHVLRLRLAMMLGALRGDRDDVLRRVVGLVVLIAGTIFAAVNASGLGEVDRLTAGIVTVLAGSAITLGFAVGPPVTASVDPLDPRRFAVVGPEPRPLAGALLLAGFLSVPVLAVLVLAISVAVAWSEQGVSVFASVASIVLGLTTCVLLARVSMALGTLVKRPRQSRELAGVYLVAVLVVVVPVAVFLGSLEWRGTVPTQLVSAAEVLAWTPVGAAWGIALAPTPGAAVGSAVVAVATVAVLAALWFVLVRILLTTTPRPVAVRERGGLGWFALLPGTPGGAVAARSLSYWLRDRRYLVNIVIVPIAAVLSMVPLVVAGVPIEVAALLPVPIMALFFGWLPHNDLAYDSTALWMHIASGVRGLSDRIGRLVPVLLIGLPILAVSIPLAIVAHGRWAFLPVLIGVCAALFLSGLGLSSISSVLAPYPVSRPGDSPFQQPQRTGSGGVLAQGLVMLGSLLAASPALWFAGHALASDSEDAVVALWAGLAAGVIVLVVGVAVGAAVFERRGTRLMEFAEAT
>NC_015125.1|WP_193374931.1|3422352_3423597_+|ATP-binding-cassette-domain-containing-protein
MVEDLTPPDAAVEEPAVEEPAVEPVEDLTPPDAAVEEPAVEELAVEAPAVEGESGAADSPAEVRDDEPVEDAASVEDPAPVEGATPVEDAASGEDATPVEDTALAQDAAPLEDPTPADAPVEESPVEADADAPSEETAATTAGAAIGAAAVEGKTSAHADDATPALTLRNVTKTFGELRAVDGIDLTIPAGSFYGLVGPNGAGKTTTLSIIAGLLRADGGTVSINGVDAAKNARAAKKMIGVLPDRLRTFDRLTGRQLLSYYGALRGLPAGLVESRSADLARAFDLVDALARPVSDYSAGMTKKVMLAGAMIHSPRLLVLDEPFEAVDPVSSAVILDILGAYVAHGGTVILSSHGMELVERVCSRVAVIVSGQVLAEGTVDEVRGEASLEQRFLELAGGLGDVEGLEWLHTFSG
>NC_015125.1|WP_013586250.1|3433937_3434792_+|Ku-protein
MRSIWKGALTFGLVNVPVKVYSATEDHDVSLHQVHNADGGRIRYQRICEIDGEVVPYSDIDKAYDDGEQTVVLTKDDLASLPSERSREIEVVEFVPSDQVDLLTLDKAYYLEPDSSSPKAYVLLRKTLEQTDRTAIVRFSLRQKTRLAALRVRDEVLVLQTLLWADEVREAAFPALDESVRISAKELEMSASLVESFSKDFDPEEFTDEYQAELRTLIDAKLEQGDAIDTDATFGTQEEEDGGEVIDLMEALRASVERSRAARAEKDEPAKKKASAKKKSSKAS
>NC_015125.1|WP_080575523.1|3434801_3435545_-|VTT-domain-containing-protein
MHPTALLPWLDPATIITNSQPWALLVVCFIIFAETGLLIGFLLPGDTLLIMAGLLSHSTPAAPNGVFGINAWWVALAIGVAAFIGGEVGYYIGHKAGPSIFERKDSGLFSRKNVERTNAFFVRFGGLTVILARFVPVVRTFAPIAAGVGHMPWRKYTLYNFIGAVLWGIGLTMLGYAVGYIPFIRDIVTEYIDVILLAAVAGTAIFIGIHYLRERSAAKREGAVTHAEAEALTLDPQTLEDGDKPAR
>NC_015125.1|WP_013586252.1|3435730_3437341_-|amidohydrolase
MSSLLVANGILFSAGAMIDGDAVGIRDGRIVATGTRREVRTILGTVDDEVDARGGLVTPGFVDAHIHLGGGAVDALRCDLAGADSLAEIDRRVRAFAAGSTASWIVGGGWDPTLFPHGGPTAAHLDELVPDRPALFLDADHHGAWVNSAALRAAGIDADTPDPFDGRIERSTDGTPSGALREGAMQLVSPLVPPSATADVARALRTIARDVVAAGITGWQEAALGLYAGYPDFSDAYRELSTTGNLVGRATGAIWVPRDLTADTIDAFVADCVERARANTTAGFPTRTAKLMLDGIIETRTAHVCTPYPDGSHGLAYFEPAVVQKLVPALNAAGISVHVHALADAAVRDALDGFAAVPADVRAGVRNHIAHLELVTPSDVPRFAELGVTANCQPYWACRNDLVRDVTLPLLGKERADSLYPFADLRAAGATLAMGSDWPVSTYDPWLGIHVAVTRRPPGEPDAEPLGAAQALPLGVALDAYTRGSADLLGLGSGTLTPGASADLAIADRDPFTGPADGIHETRNAATIVGGELFGG
>NC_015125.1|WP_013586253.1|3437413_3438436_+|NADPH:quinone-reductase
MRAITYSQTGGSSVLTLGERPVPEPGPGDVRVRIAVSGVNPTDWKAREGGRPFSFPEVTPNQDGAGIVDAVGPGVTSVSAGQRVWVYLAQHERPTGTAAEYAVIPAGRAVPLADDASFALGASLGVPAMTAHRALTVHEDGPSRLAPGALAGRTVLVQGGAGAVGHAAIQLAVWAGATVIATVSSDEKEALARAAGAHHVLQYPSETLADGIRDLAPNGVEHIVEVAIADNAALDVEVIANHGSIGYYADNGGDSFTAAVRASFAKNVRWQGLLLYTVGETALTAAAEDVSAAVADGALPVGDEAGLPLTWFPLAETAAAHDAVADGTTGKVLIRVSDED
>NC_015125.1|WP_013586254.1|3438419_3439079_-|DUF1275-domain-containing-protein
MKDVDREALALSAALAAVAGFVDAIGFLDTGGLFVSFMSGNSTQGAVGLLDGSPQVALVSAGIIAAFVIGVTAGATVSMRAARARAWVVAGSAAGVAATAALALGGGSTTWRVGVLAAAMGALNTLFLAEGRARVAITYATGTLVSLGLGLAALLTGGSRTAWRRPLLLWSSLVTGAVIGGLAHRWGSPIALGIAALALAGAAAVIALRGRGSAVSPRR
>NC_015125.1|WP_158309759.1|3439212_3440988_-|M20/M25/M40-family-metallo-hydrolase
MPRNTLLPPPRRVRRASAIAATSALVGGALMIAPAAFAAPDAEVPNDLGLTGADVMTHLTELSAISESFADEGYRSWNGPGYEAAAQYAEKVLADTGAFTVTRHAFDVPYSEFGVASLVVDGTVYTGSHFDNSEGTDGDVTAPLALPVSEDGGFLGCAASDYAEVPAGSIVLVQRGICSFEEKIGFASDAGAAAVFVYNNERPPEENTAPEDQLTNVTSGPRNEEDSPAATLPQASGDAIEALITAAPDDAPVEGTATIEKQFLVGTSFNIIADSTAGDPEDTVVIGAHLDGVAEGPGVNDNASGSAAVLALAEKIAASEVPNDKRIRLALWGAEEIGLLGSTAYVNDLVANDAAEWDRISSYLNYDMIGSENFTVGVYDADRSTFPAEGVNIPEGSEAIEKIYTDYFDTIEQPWIDTEYSGRSDYQAFIDNGVPSGGLFSGGDDIKTEEQVEMFGGTPGVFMDRNYHTVNDTLANINRDSVDIFAPAIGHAAAALAWTAAVEPSPEPTVEPTGEPTLEPTAEPTTEPTAEPTTQPSPSPSTTTGPGPRDNLAKTGSNAEGSALPAIGAGMLVLGALIAAGTVIARRRPQE
>NC_015125.1|WP_080575524.1|3441148_3442387_-|MFS-transporter
MIYGPTLLFAIGEGAVIPLIPVIANRLGADVALAALVAAALVVGQLCGNIPAGWAVARFGERITMGVAGIVILGGLVGVVFAGTLAIFAAAVFLIGFCAASFALARHSFMTTRVPLHFRARALSLLGGTFRLGMFVGPFISAALLGIFGDETASILFFAVCQVATILLVFLGPDPEKAVPVTGVAAGEPAEGASREAEDTGEPVSGAIPTAERAGVFRTMWRFRAVLARLGLAAASLSAVRSARQVVLPLWGVSLGLDASTIAVVVGVSGAIDFALFYASGQVMDRFGRLWAALPAMVLMGAGFLALAFTHDLTSAAMWFAMFAAVLGVGNGLSSGILLTLGADLAPPDEPAAFLGSWRTLTDAGGAVAPVLISALTATVSLSGAVGAMGVIAALGAFGFVRWVPRYVPRAR
>NC_015125.1|WP_013586257.1|3442457_3443570_+|peptide-chain-release-factor-2
MLELDLTADIQALRSTFADIQAVVDVDALKADIDRLSEEAGAPDLWDDVDNAQKVTSRLSHRQAELKRITEIEQRLDDLEVLVELAIEMDDEDSADEARRELASLKDVIGQLEVQTLLDGEYDSRSAVVTIRSGAGGDDATDFAEMLLRMYLRWAERHKYPVKVMDTSYAEGAGIKSATFEVDVPYAYGTLSVEAGTHRLARISPFGGADKRQTSFAAVEVIPVMEEAVEVEVPEGDIRVDVFRSSGPGGQSVNTTDSAVRITHIPTGLVVSMQNEKSQIQNRAAAMRVLQTRLLLLKREEEAAKKKELAGTITASWGDQMRSYFLYGQQLVKDLRTGYEVGNPAVVFDGDLDGLIAAGIRWRKRKDDDD
>NC_015125.1|WP_013586258.1|3443669_3444689_+|cell-division-ATP-binding-protein-FtsE
MIRFENVTKRYRGTTKPALNAVDFEVQRGEFVFLVGASGSGKSSCLQLILRAETPSDGRVVVLGRDLRTLSNRKVPYFRRHIGSVFQDFRLLPNKTVHQNVAFTLQVTGASRGFVQQAVPEVLALVGLDGKEKRLPHELSGGEQQRVAIARALVNRPQVLLADEPTGNLDPGTSIDIMRLLARINAGGTTVVMATHEAGFVDQMQRRVIELRGGEMVRDERHGGYGDRSGLPVLAPEVEKGAAAVAALTAVLEVQREVTSITGPVEPLRGPEGSEQVSAAPVEPESPSVTTSPAAERREPATNTRSIPVSTPEVDALGLADRLGLAEKKDRDDEVGPTS
>NC_015125.1|WP_013586259.1|3444685_3445603_+|FtsX-like-permease-family-protein
MRFGLILSEAFSGLRRNASMVISVILVTFVSLTFVGAAMLMQMQIGKMQSYWADRAQVAVFMCSTVSDSATCTPGEAATQEQIDAVRATLDGDALKPLIRDYSFSTSDEAFQNAQGLLSSDIAGVVTADQFNATFSINLVDQGQSDVIAEAFSGQAGVEEVKDQMQYLEPLFQSLTVATYVAVGIAGLMLIAAVLLIATTIRLSAFARRRELGIMRLVGASNRFIQTPFILEGVLAALIGSALASVAVWAMVQVGVERYLRDRIGFITSWVGLSDVAIVVPVIVVIGVVLSALSAGFAIRRWLRA

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NZ_CP032676	Rhodococcus rhodochrous strain ATCC BAA870 plasmid pNit, complete sequence	391051-391078	3	0.893
NC_015125_3	3.3|868190|28|NC_015125|CRT	868190-868217	28	NZ_CP040820	Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence	70498-70525	4	0.857
NC_015125_3	3.9|868193|28|NC_015125|CRISPRCasFinder	868193-868220	28	NZ_CP040820	Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence	70495-70522	4	0.857
NC_015125_3	3.9|868193|28|NC_015125|CRISPRCasFinder	868193-868220	28	NZ_CP054616	Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence	592945-592972	4	0.857
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	MK433264	Gordonia phage Tiamoceli, complete genome	1632-1659	4	0.857
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	MT952843	Gordonia phage Twonlo, complete genome	1632-1659	4	0.857
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	MK977704	Gordonia Terrae phage RoadKill, complete genome	1632-1659	4	0.857
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	786219-786246	4	0.857
NC_015125_19	19.1|3433827|25|NC_015125|CRISPRCasFinder	3433827-3433851	25	NC_017326	Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence	62341-62365	4	0.84
NC_015125_19	19.1|3433827|25|NC_015125|CRISPRCasFinder	3433827-3433851	25	NZ_CP009146	Sinorhizobium meliloti strain RMO17 plasmid pSymB, complete sequence	62631-62655	4	0.84
NC_015125_19	19.1|3433827|25|NC_015125|CRISPRCasFinder	3433827-3433851	25	NZ_CP021820	Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence	392594-392618	4	0.84
NC_015125_19	19.1|3433827|25|NC_015125|CRISPRCasFinder	3433827-3433851	25	NZ_CP021831	Sinorhizobium meliloti strain HM006 plasmid psymB, complete sequence	314618-314642	4	0.84
NC_015125_19	19.1|3433827|25|NC_015125|CRISPRCasFinder	3433827-3433851	25	NZ_CP021218	Sinorhizobium meliloti RU11/001 plasmid pSymB, complete sequence	215824-215848	4	0.84
NC_015125_19	19.1|3433827|25|NC_015125|CRISPRCasFinder	3433827-3433851	25	NZ_CP026527	Sinorhizobium meliloti strain AK21 plasmid pSymB, complete sequence	65241-65265	4	0.84
NC_015125_19	19.1|3433827|25|NC_015125|CRISPRCasFinder	3433827-3433851	25	NZ_CP019484	Sinorhizobium meliloti strain B401 plasmid pSymB, complete sequence	205735-205759	4	0.84
NC_015125_19	19.1|3433827|25|NC_015125|CRISPRCasFinder	3433827-3433851	25	NZ_CP019487	Sinorhizobium meliloti strain B399 plasmid pSym, complete sequence	1570383-1570407	4	0.84
NC_015125_3	3.2|868140|27|NC_015125|CRT	868140-868166	27	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	109042-109068	5	0.815
NC_015125_3	3.2|868140|27|NC_015125|CRT	868140-868166	27	NZ_CP020539	Sphingobium herbicidovorans strain MH plasmid pMSHV, complete sequence	333824-333850	5	0.815
NC_015125_3	3.3|868190|28|NC_015125|CRT	868190-868217	28	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	1256568-1256595	5	0.821
NC_015125_3	3.3|868190|28|NC_015125|CRT	868190-868217	28	NZ_CP054616	Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence	592942-592969	5	0.821
NC_015125_3	3.3|868190|28|NC_015125|CRT	868190-868217	28	NC_021278	Mycobacteroides abscessus subsp. bolletii 50594 plasmid 1, complete sequence	129663-129690	5	0.821
NC_015125_3	3.3|868190|28|NC_015125|CRT	868190-868217	28	NZ_CP018064	Rhodococcus sp. 2G plasmid p1, complete sequence	361184-361211	5	0.821
NC_015125_3	3.6|868343|28|NC_015125|CRT	868343-868370	28	NC_010625	Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence	1242328-1242355	5	0.821
NC_015125_3	3.7|868092|28|NC_015125|CRISPRCasFinder	868092-868119	28	NZ_CP010016	Burkholderia thailandensis 34 plasmid unnamed, complete sequence	123096-123123	5	0.821
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NC_010510	Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence	329092-329119	5	0.821
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NZ_CP034431	Bradyrhizobium sp. LCT2 plasmid pLCT2, complete sequence	109861-109888	5	0.821
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NZ_AP014686	Bradyrhizobium diazoefficiens strain NK6 plasmid pNK6b, complete sequence	161926-161953	5	0.821
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NZ_CP049700	Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2a, complete sequence	4107-4134	5	0.821
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NZ_CP049700	Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2a, complete sequence	452026-452053	5	0.821
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	KY945355	Mycobacterium phage Shandong1, complete genome	14498-14525	5	0.821
NC_015125_3	3.1|868089|28|NC_015125|CRT	868089-868116	28	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	549847-549874	6	0.786
NC_015125_3	3.1|868089|28|NC_015125|CRT	868089-868116	28	NZ_CP010016	Burkholderia thailandensis 34 plasmid unnamed, complete sequence	123099-123126	6	0.786
NC_015125_3	3.3|868190|28|NC_015125|CRT	868190-868217	28	KT381864	Thiobacimonas phage vB_ThpS-P1, complete genome	10310-10337	6	0.786
NC_015125_3	3.7|868092|28|NC_015125|CRISPRCasFinder	868092-868119	28	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	549844-549871	6	0.786
NC_015125_3	3.9|868193|28|NC_015125|CRISPRCasFinder	868193-868220	28	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	1256565-1256592	6	0.786
NC_015125_3	3.9|868193|28|NC_015125|CRISPRCasFinder	868193-868220	28	NZ_CP022991	Paraburkholderia aromaticivorans strain BN5 plasmid pBN1, complete sequence	651757-651784	6	0.786
NC_015125_3	3.9|868193|28|NC_015125|CRISPRCasFinder	868193-868220	28	NC_021278	Mycobacteroides abscessus subsp. bolletii 50594 plasmid 1, complete sequence	129660-129687	6	0.786
NC_015125_3	3.9|868193|28|NC_015125|CRISPRCasFinder	868193-868220	28	KT381864	Thiobacimonas phage vB_ThpS-P1, complete genome	10313-10340	6	0.786
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NZ_AP018516	Acetobacter orientalis strain FAN1 plasmid pAOF1, complete sequence	98423-98450	6	0.786
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NC_010553	Burkholderia ambifaria MC40-6 plasmid pBMC401, complete sequence	187216-187243	6	0.786
NC_015125_3	3.1|868089|28|NC_015125|CRT	868089-868116	28	NZ_CP005092	Sphingobium sp. TKS plasmid pTK8, complete sequence	4468-4495	7	0.75
NC_015125_3	3.5|868292|28|NC_015125|CRT	868292-868319	28	NC_010627	Paraburkholderia phymatum STM815 plasmid pBPHY02, complete sequence	72362-72389	7	0.75
NC_015125_3	3.6|868343|28|NC_015125|CRT	868343-868370	28	NZ_AP018516	Acetobacter orientalis strain FAN1 plasmid pAOF1, complete sequence	98420-98447	7	0.75
NC_015125_3	3.7|868092|28|NC_015125|CRISPRCasFinder	868092-868119	28	NZ_CP005092	Sphingobium sp. TKS plasmid pTK8, complete sequence	4471-4498	7	0.75
NC_015125_3	3.9|868193|28|NC_015125|CRISPRCasFinder	868193-868220	28	NZ_CP020372	Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence	16198-16225	7	0.75
NC_015125_3	3.9|868193|28|NC_015125|CRISPRCasFinder	868193-868220	28	NZ_CP011869	Pseudonocardia sp. HH130629-09 plasmid pLS1-1, complete sequence	238523-238550	7	0.75
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NZ_CP018857	Xanthomonas citri pv. citri strain LH276 plasmid pLH276.3, complete sequence	16456-16483	7	0.75
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NZ_CP018853	Xanthomonas citri pv. citri strain LJ207-7 plasmid pLJ207-7.3, complete sequence	2772-2799	7	0.75
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NZ_CP024080	Xanthomonas citri pv. citri strain Xcc29-1 plasmid pXAC47, complete sequence	16684-16711	7	0.75
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	NC_020798	Xanthomonas axonopodis Xac29-1 plasmid pXAC47, complete sequence	16686-16713	7	0.75
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	MH590601	Streptomyces phage Haizum, complete genome	18724-18751	7	0.75
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	MT897906	Arthrobacter phage Tweety19, complete genome	24968-24995	7	0.75
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	MF766046	Streptomyces phage Diane, complete genome	19085-19112	7	0.75
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NC_020548	Azoarcus sp. KH32C plasmid pAZKH, complete sequence	286209-286243	7	0.8
NC_015125_17	17.1|3252558|34|NC_015125|CRISPRCasFinder	3252558-3252591	34	NZ_CP022220	Bradyrhizobium guangxiense strain CCBAU 53363 plasmid p53363, complete sequence	153183-153216	7	0.794
NC_015125_17	17.1|3252558|34|NC_015125|CRISPRCasFinder	3252558-3252591	34	NZ_CP030052	Bradyrhizobium guangdongense strain CCBAU 51649 plasmid unnamed, complete sequence	745226-745259	7	0.794
NC_015125_17	17.1|3252558|34|NC_015125|CRISPRCasFinder	3252558-3252591	34	NZ_CP030054	Bradyrhizobium guangzhouense strain CCBAU 51670 plasmid unnamed1, complete sequence	924820-924853	7	0.794
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	MF766048	Streptomyces phage Tefunt, complete genome	18727-18754	8	0.714
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	MF766044	Streptomyces phage Amethyst, complete genome	18702-18729	8	0.714
NC_015125_3	3.12|868346|28|NC_015125|CRISPRCasFinder	868346-868373	28	MK392364	Streptomyces phage Nishikigoi, complete genome	18724-18751	8	0.714
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NC_010311	Streptomyces sp. HK1 plasmid pSHK1, complete sequence	142921-142955	8	0.771
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP009803	Streptomyces sp. FR-008 plasmid pSSFR1, complete sequence	27564-27598	8	0.771
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	ASHF01000034	Streptomyces sp. GBA 94-10 plasmid pGBA1, complete sequence, whole genome shotgun sequence	178789-178823	8	0.771
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP029339	Streptomyces sp. SM17 plasmid pSM17A, complete sequence	41624-41658	8	0.771
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP026489	Streptomyces sp. 604F plasmid unnamed, complete sequence	146743-146777	8	0.771
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013526	Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence	609010-609044	9	0.743
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013556	Rhizobium phaseoli strain N931 plasmid pRphaN931d, complete sequence	622811-622845	9	0.743
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013589	Rhizobium phaseoli strain N161 plasmid pRphaN161d, complete sequence	611554-611588	9	0.743
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013579	Rhizobium phaseoli strain N671 plasmid pRphaN671e, complete sequence	604902-604936	9	0.743
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013536	Rhizobium phaseoli strain R650 plasmid pRphaR650d, complete sequence	292819-292853	9	0.743
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013541	Rhizobium phaseoli strain R630 plasmid pRphaR630d, complete sequence	625487-625521	9	0.743
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013546	Rhizobium phaseoli strain R620 plasmid pRphaR620d, complete sequence	619325-619359	9	0.743
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013567	Rhizobium phaseoli strain N831 plasmid pRphaN831d, complete sequence	622811-622845	9	0.743
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013573	Rhizobium phaseoli strain N771 plasmid pRphaN771e, complete sequence	604902-604936	9	0.743
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013515	Rhizobium sp. N1314 plasmid pRspN1314d, complete sequence	331065-331099	9	0.743
NC_015125_4	4.1|1249067|35|NC_015125|CRT	1249067-1249101	35	NZ_CP013605	Rhizobium sp. N731 plasmid pRspN731d, complete sequence	331059-331093	9	0.743
NC_015125_4	4.2|1249121|35|NC_015125|CRT	1249121-1249155	35	NZ_CP033509	Mesorhizobium jarvisii strain ATCC 700743 plasmid pMJ700743b, complete sequence	1775-1809	9	0.743
NC_015125_4	4.2|1249121|35|NC_015125|CRT	1249121-1249155	35	NZ_CP033370	Mesorhizobium loti strain SU343 plasmid pMLSU343b, complete sequence	6984-7018	9	0.743
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NC_019848	Sinorhizobium meliloti GR4 plasmid pRmeGR4c, complete sequence	375227-375261	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NC_017327	Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence	531339-531373	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP021798	Sinorhizobium meliloti strain USDA1106 plasmid psymA, complete sequence	1027902-1027936	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP009145	Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence	550411-550445	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP021801	Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence	472462-472496	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP021830	Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence	1471624-1471658	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP021824	Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence	428384-428418	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP021794	Sinorhizobium meliloti strain USDA1157 plasmid psymA, complete sequence	962680-962714	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP021809	Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence	930071-930105	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP021217	Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence	116256-116290	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NC_003037	Sinorhizobium meliloti 1021 plasmid pSymA, complete sequence	1054778-1054812	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP019585	Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymA, complete sequence	1077222-1077256	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NC_017324	Sinorhizobium meliloti BL225C plasmid pSINMEB01, complete sequence	17248-17282	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP021827	Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence	1116750-1116784	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NC_018683	Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence	1257102-1257136	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP021805	Sinorhizobium meliloti strain T073 plasmid psymA, complete sequence	1355324-1355358	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP026526	Sinorhizobium meliloti strain AK21 plasmid pSymA, complete sequence	1342829-1342863	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP019483	Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence	909222-909256	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NZ_CP019486	Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence	871971-872005	10	0.714
NC_015125_18	18.1|3431140|35|NC_015125|CRISPRCasFinder	3431140-3431174	35	NC_020527	Sinorhizobium meliloti 2011 plasmid pSymA, complete sequence	1053117-1053151	10	0.714

1. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NZ_CP032676 (Rhodococcus rhodochrous strain ATCC BAA870 plasmid pNit, complete sequence) position: , mismatch: 3, identity: 0.893

-gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
agaca-cgccgatcgccgtcgagaccgac	Protospacer
 **** *********.******* *****

2. spacer 3.3|868190|28|NC_015125|CRT matches to NZ_CP040820 (Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence) position: , mismatch: 4, identity: 0.857

gctctcgtcgccccgggcgctggtgccg	CRISPR spacer
ggcctcgtcgcgccgggcgatggtgccg	Protospacer
* .******** ******* ********

3. spacer 3.9|868193|28|NC_015125|CRISPRCasFinder matches to NZ_CP040820 (Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence) position: , mismatch: 4, identity: 0.857

ctcgtcgccccgggcgctggtgccggac	CRISPR spacer
ctcgtcgcgccgggcgatggtgccggtg	Protospacer
******** ******* *********  

4. spacer 3.9|868193|28|NC_015125|CRISPRCasFinder matches to NZ_CP054616 (Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.857

ctcgtcgccccgggcgctggtgccggac	CRISPR spacer
ttcgtcgccgcgggcgctggtgacggag	Protospacer
.******** ************ **** 

5. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to MK433264 (Gordonia phage Tiamoceli, complete genome) position: , mismatch: 4, identity: 0.857

gacac-cgccgatcgtcgtcgagcccgac	CRISPR spacer
-acgcgtgccggtcgtcgtcgagcccgac	Protospacer
 **.* .****.*****************

6. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to MT952843 (Gordonia phage Twonlo, complete genome) position: , mismatch: 4, identity: 0.857

gacac-cgccgatcgtcgtcgagcccgac	CRISPR spacer
-acgcgtgccggtcgtcgtcgagcccgac	Protospacer
 **.* .****.*****************

7. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to MK977704 (Gordonia Terrae phage RoadKill, complete genome) position: , mismatch: 4, identity: 0.857

gacac-cgccgatcgtcgtcgagcccgac	CRISPR spacer
-acgcgtgccggtcgtcgtcgagcccgac	Protospacer
 **.* .****.*****************

8. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 4, identity: 0.857

-gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
caaca-cgctgatcgtcgtcgagcacgac	Protospacer
 .*** ***.************** ****

9. spacer 19.1|3433827|25|NC_015125|CRISPRCasFinder matches to NC_017326 (Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence) position: , mismatch: 4, identity: 0.84

gcgggctcagccacctcgcgcgtga	CRISPR spacer
ccgggctcagccacctcgcggatgt	Protospacer
 ******************* .** 

10. spacer 19.1|3433827|25|NC_015125|CRISPRCasFinder matches to NZ_CP009146 (Sinorhizobium meliloti strain RMO17 plasmid pSymB, complete sequence) position: , mismatch: 4, identity: 0.84

gcgggctcagccacctcgcgcgtga	CRISPR spacer
ccgggctcagccacctcgcggatgt	Protospacer
 ******************* .** 

11. spacer 19.1|3433827|25|NC_015125|CRISPRCasFinder matches to NZ_CP021820 (Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence) position: , mismatch: 4, identity: 0.84

gcgggctcagccacctcgcgcgtga	CRISPR spacer
ccgggctcagccacctcgcggatgt	Protospacer
 ******************* .** 

12. spacer 19.1|3433827|25|NC_015125|CRISPRCasFinder matches to NZ_CP021831 (Sinorhizobium meliloti strain HM006 plasmid psymB, complete sequence) position: , mismatch: 4, identity: 0.84

gcgggctcagccacctcgcgcgtga	CRISPR spacer
ccgggctcagccacctcgcggatgt	Protospacer
 ******************* .** 

13. spacer 19.1|3433827|25|NC_015125|CRISPRCasFinder matches to NZ_CP021218 (Sinorhizobium meliloti RU11/001 plasmid pSymB, complete sequence) position: , mismatch: 4, identity: 0.84

gcgggctcagccacctcgcgcgtga	CRISPR spacer
ccgggctcagccacctcgcggatgt	Protospacer
 ******************* .** 

14. spacer 19.1|3433827|25|NC_015125|CRISPRCasFinder matches to NZ_CP026527 (Sinorhizobium meliloti strain AK21 plasmid pSymB, complete sequence) position: , mismatch: 4, identity: 0.84

gcgggctcagccacctcgcgcgtga	CRISPR spacer
ccgggctcagccacctcgcggatgt	Protospacer
 ******************* .** 

15. spacer 19.1|3433827|25|NC_015125|CRISPRCasFinder matches to NZ_CP019484 (Sinorhizobium meliloti strain B401 plasmid pSymB, complete sequence) position: , mismatch: 4, identity: 0.84

gcgggctcagccacctcgcgcgtga	CRISPR spacer
ccgggctcagccacctcgcggatgt	Protospacer
 ******************* .** 

16. spacer 19.1|3433827|25|NC_015125|CRISPRCasFinder matches to NZ_CP019487 (Sinorhizobium meliloti strain B399 plasmid pSym, complete sequence) position: , mismatch: 4, identity: 0.84

gcgggctcagccacctcgcgcgtga	CRISPR spacer
ccgggctcagccacctcgcggatgt	Protospacer
 ******************* .** 

17. spacer 3.2|868140|27|NC_015125|CRT matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 5, identity: 0.815

ctcgaccgctccggcgcggtagttccc	CRISPR spacer
ctcgaccgatccggcgcggtagccgcg	Protospacer
******** *************.. * 

18. spacer 3.2|868140|27|NC_015125|CRT matches to NZ_CP020539 (Sphingobium herbicidovorans strain MH plasmid pMSHV, complete sequence) position: , mismatch: 5, identity: 0.815

ctcgaccgctccggcgcggtagttccc	CRISPR spacer
cccgaccgatccggcgcggtagtgcat	Protospacer
*.****** ************** * .

19. spacer 3.3|868190|28|NC_015125|CRT matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 5, identity: 0.821

gctctcgtcgccccgggcgctggtgccg	CRISPR spacer
gagatcgtcgccaccggcgctggtgccg	Protospacer
*   ******** * *************

20. spacer 3.3|868190|28|NC_015125|CRT matches to NZ_CP054616 (Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.821

gctctcgtcgccccgggcgctggtgccg	CRISPR spacer
gtcttcgtcgccgcgggcgctggtgacg	Protospacer
*...******** ************ **

21. spacer 3.3|868190|28|NC_015125|CRT matches to NC_021278 (Mycobacteroides abscessus subsp. bolletii 50594 plasmid 1, complete sequence) position: , mismatch: 5, identity: 0.821

gctctcgtcgccccgggcgctggtgccg	CRISPR spacer
ggtctcgtcgcccggggagctggtgcac	Protospacer
* *********** *** ********  

22. spacer 3.3|868190|28|NC_015125|CRT matches to NZ_CP018064 (Rhodococcus sp. 2G plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.821

gctctcgtcgccccgggcgctggtgccg	CRISPR spacer
gccctcgtcgccccgggcgcgggccgcg	Protospacer
**.***************** **.  **

23. spacer 3.6|868343|28|NC_015125|CRT matches to NC_010625 (Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence) position: , mismatch: 5, identity: 0.821

ctcgacaccgccgatcgtcgtcgagccc	CRISPR spacer
cccgacatcgccgaacgtcgtcgagggc	Protospacer
*.*****.****** **********  *

24. spacer 3.7|868092|28|NC_015125|CRISPRCasFinder matches to NZ_CP010016 (Burkholderia thailandensis 34 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.821

cacgctgccgtcgcggtacgacccggac	CRISPR spacer
cccgctgccgacgctgtacgacccgcag	Protospacer
* ******** *** ********** * 

25. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NC_010510 (Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence) position: , mismatch: 5, identity: 0.821

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
gcacccgcggatcgtcgccgagcccgac	Protospacer
*   **** ********.**********

26. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NZ_CP034431 (Bradyrhizobium sp. LCT2 plasmid pLCT2, complete sequence) position: , mismatch: 5, identity: 0.821

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
ggcgcggccgttcgtcgtcgagcccgaa	Protospacer
*.*.* **** **************** 

27. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NZ_AP014686 (Bradyrhizobium diazoefficiens strain NK6 plasmid pNK6b, complete sequence) position: , mismatch: 5, identity: 0.821

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
ggcgcggccgttcgtcgtcgagcccgaa	Protospacer
*.*.* **** **************** 

28. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NZ_CP049700 (Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2a, complete sequence) position: , mismatch: 5, identity: 0.821

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
ggcgcggccgttcgtcgtcgagcccgaa	Protospacer
*.*.* **** **************** 

29. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NZ_CP049700 (Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2a, complete sequence) position: , mismatch: 5, identity: 0.821

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
ggcgcggccgttcgtcgtcgagcccgaa	Protospacer
*.*.* **** **************** 

30. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to KY945355 (Mycobacterium phage Shandong1, complete genome) position: , mismatch: 5, identity: 0.821

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
gccctcggcgatcgtcgacgagcccgac	Protospacer
* * .** ********* **********

31. spacer 3.1|868089|28|NC_015125|CRT matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.786

ctccacgctgccgtcgcggtacgacccg	CRISPR spacer
catcacgctgtcgtcccggtacgaccac	Protospacer
* .*******.**** **********  

32. spacer 3.1|868089|28|NC_015125|CRT matches to NZ_CP010016 (Burkholderia thailandensis 34 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.786

ctccacgctgccgtcgcggtacgacccg	CRISPR spacer
agtcccgctgccgacgctgtacgacccg	Protospacer
  .* ******** *** **********

33. spacer 3.3|868190|28|NC_015125|CRT matches to KT381864 (Thiobacimonas phage vB_ThpS-P1, complete genome) position: , mismatch: 6, identity: 0.786

gctctcgtcgccccgggcgctggtgccg	CRISPR spacer
aacctcgtcggcgcgggcgctggtgcgg	Protospacer
. .******* * ************* *

34. spacer 3.7|868092|28|NC_015125|CRISPRCasFinder matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.786

cacgctgccgtcgcggtacgacccggac	CRISPR spacer
cacgctgtcgtcccggtacgaccacggt	Protospacer
*******.**** **********  *..

35. spacer 3.9|868193|28|NC_015125|CRISPRCasFinder matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 6, identity: 0.786

ctcgtcgccccgggcgctggtgccggac	CRISPR spacer
atcgtcgccaccggcgctggtgccgccg	Protospacer
 ******** * *************   

36. spacer 3.9|868193|28|NC_015125|CRISPRCasFinder matches to NZ_CP022991 (Paraburkholderia aromaticivorans strain BN5 plasmid pBN1, complete sequence) position: , mismatch: 6, identity: 0.786

ctcgtcgccccgggcgctggtgccggac	CRISPR spacer
cgtcacgcgccgggtgctggtgccggac	Protospacer
* .  *** *****.*************

37. spacer 3.9|868193|28|NC_015125|CRISPRCasFinder matches to NC_021278 (Mycobacteroides abscessus subsp. bolletii 50594 plasmid 1, complete sequence) position: , mismatch: 6, identity: 0.786

ctcgtcgccccgggcgctggtgccggac	CRISPR spacer
ctcgtcgcccggggagctggtgcacgtg	Protospacer
********** *** ********  *  

38. spacer 3.9|868193|28|NC_015125|CRISPRCasFinder matches to KT381864 (Thiobacimonas phage vB_ThpS-P1, complete genome) position: , mismatch: 6, identity: 0.786

ctcgtcgccccgggcgctggtgccggac	CRISPR spacer
ctcgtcggcgcgggcgctggtgcggtcg	Protospacer
******* * ************* *   

39. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NZ_AP018516 (Acetobacter orientalis strain FAN1 plasmid pAOF1, complete sequence) position: , mismatch: 6, identity: 0.786

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
cccaccgttgatcgtcgtcgagcccgta	Protospacer
  *****..*****************  

40. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NC_010553 (Burkholderia ambifaria MC40-6 plasmid pBMC401, complete sequence) position: , mismatch: 6, identity: 0.786

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
tggagcggcgatcggcgtcgagcccgac	Protospacer
 . * ** ****** *************

41. spacer 3.1|868089|28|NC_015125|CRT matches to NZ_CP005092 (Sphingobium sp. TKS plasmid pTK8, complete sequence) position: , mismatch: 7, identity: 0.75

ctccacgctgccgtcgcggtacgacccg	CRISPR spacer
gctgccgctgccgtcgcgctacgaccgg	Protospacer
 ..  ************* ******* *

42. spacer 3.5|868292|28|NC_015125|CRT matches to NC_010627 (Paraburkholderia phymatum STM815 plasmid pBPHY02, complete sequence) position: , mismatch: 7, identity: 0.75

cgtcacgtcgcccgaggcgtaggaaccc	CRISPR spacer
cgtcacgtcgcccgaggcgttcagcgtc	Protospacer
********************  ..  .*

43. spacer 3.6|868343|28|NC_015125|CRT matches to NZ_AP018516 (Acetobacter orientalis strain FAN1 plasmid pAOF1, complete sequence) position: , mismatch: 7, identity: 0.75

ctcgacaccgccgatcgtcgtcgagccc	CRISPR spacer
tatcccaccgttgatcgtcgtcgagccc	Protospacer
. .  *****..****************

44. spacer 3.7|868092|28|NC_015125|CRISPRCasFinder matches to NZ_CP005092 (Sphingobium sp. TKS plasmid pTK8, complete sequence) position: , mismatch: 7, identity: 0.75

cacgctgccgtcgcggtacgacccggac	CRISPR spacer
gccgctgccgtcgcgctacgaccggcgg	Protospacer
  ************* ******* * . 

45. spacer 3.9|868193|28|NC_015125|CRISPRCasFinder matches to NZ_CP020372 (Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence) position: , mismatch: 7, identity: 0.75

ctcgtcgccccgggcgctggtgccggac	CRISPR spacer
aggcgcgccccgggtgctggtgccgcac	Protospacer
     *********.********** **

46. spacer 3.9|868193|28|NC_015125|CRISPRCasFinder matches to NZ_CP011869 (Pseudonocardia sp. HH130629-09 plasmid pLS1-1, complete sequence) position: , mismatch: 7, identity: 0.75

ctcgtcgccccgggcgctggtgccggac	CRISPR spacer
ggccccgccccgggcgctggggccggcg	Protospacer
  * .*************** *****  

47. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NZ_CP018857 (Xanthomonas citri pv. citri strain LH276 plasmid pLH276.3, complete sequence) position: , mismatch: 7, identity: 0.75

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
catcgcgccgatcgtcgtcaagcccgtg	Protospacer
 *.  **************.******  

48. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NZ_CP018853 (Xanthomonas citri pv. citri strain LJ207-7 plasmid pLJ207-7.3, complete sequence) position: , mismatch: 7, identity: 0.75

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
catcgcgccgatcgtcgtcaagcccgtg	Protospacer
 *.  **************.******  

49. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NZ_CP024080 (Xanthomonas citri pv. citri strain Xcc29-1 plasmid pXAC47, complete sequence) position: , mismatch: 7, identity: 0.75

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
catcgcgccgatcgtcgtcaagcccgtg	Protospacer
 *.  **************.******  

50. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to NC_020798 (Xanthomonas axonopodis Xac29-1 plasmid pXAC47, complete sequence) position: , mismatch: 7, identity: 0.75

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
catcgcgccgatcgtcgtcaagcccgtg	Protospacer
 *.  **************.******  

51. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to MH590601 (Streptomyces phage Haizum, complete genome) position: , mismatch: 7, identity: 0.75

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
ggtcgagccgatcgtcgtcgagccggag	Protospacer
*..   ****************** ** 

52. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to MT897906 (Arthrobacter phage Tweety19, complete genome) position: , mismatch: 7, identity: 0.75

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
acttctgccgatcgtcgacgagcccgag	Protospacer
. . *.*********** ********* 

53. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to MF766046 (Streptomyces phage Diane, complete genome) position: , mismatch: 7, identity: 0.75

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
ggtcgagccgatcgtcgtcgagccggag	Protospacer
*..   ****************** ** 

54. spacer 4.1|1249067|35|NC_015125|CRT matches to NC_020548 (Azoarcus sp. KH32C plasmid pAZKH, complete sequence) position: , mismatch: 7, identity: 0.8

atcatcgtcgacggcctcgtgggcgacgtcaacgc-	CRISPR spacer
ctgctcgtcgacggccgcgtgcgcgacgtc-gcgca	Protospacer
 *  ************ **** ******** .*** 

55. spacer 17.1|3252558|34|NC_015125|CRISPRCasFinder matches to NZ_CP022220 (Bradyrhizobium guangxiense strain CCBAU 53363 plasmid p53363, complete sequence) position: , mismatch: 7, identity: 0.794

cgcggtccggtggcttcgacgggctcagccacct	CRISPR spacer
cgcgctccggtggcttcgacgagctgcgatagct	Protospacer
**** ****************.***  * .* **

56. spacer 17.1|3252558|34|NC_015125|CRISPRCasFinder matches to NZ_CP030052 (Bradyrhizobium guangdongense strain CCBAU 51649 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.794

cgcggtccggtggcttcgacgggctcagccacct	CRISPR spacer
cgcgctccggtggcttcgacgagctgcgatagct	Protospacer
**** ****************.***  * .* **

57. spacer 17.1|3252558|34|NC_015125|CRISPRCasFinder matches to NZ_CP030054 (Bradyrhizobium guangzhouense strain CCBAU 51670 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.794

cgcggtccggtggcttcgacgggctcagccacct	CRISPR spacer
cgcgctccggtggcttcgacgagctgcgatagct	Protospacer
**** ****************.***  * .* **

58. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to MF766048 (Streptomyces phage Tefunt, complete genome) position: , mismatch: 8, identity: 0.714

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
agtcgagccgatcgtcgtcgagccggag	Protospacer
...   ****************** ** 

59. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to MF766044 (Streptomyces phage Amethyst, complete genome) position: , mismatch: 8, identity: 0.714

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
cgtcgagccgatcgtcgtcgagccggag	Protospacer
 ..   ****************** ** 

60. spacer 3.12|868346|28|NC_015125|CRISPRCasFinder matches to MK392364 (Streptomyces phage Nishikigoi, complete genome) position: , mismatch: 8, identity: 0.714

gacaccgccgatcgtcgtcgagcccgac	CRISPR spacer
agtcgagccgatcgtcgtcgagccggag	Protospacer
...   ****************** ** 

61. spacer 4.1|1249067|35|NC_015125|CRT matches to NC_010311 (Streptomyces sp. HK1 plasmid pSHK1, complete sequence) position: , mismatch: 8, identity: 0.771

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
ccccgcgtcgtcggcctcgtgggcgacctcaagga	Protospacer
 .*  ***** **************** **** * 

62. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP009803 (Streptomyces sp. FR-008 plasmid pSSFR1, complete sequence) position: , mismatch: 8, identity: 0.771

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
ccccgcgtcgtcggcctcgtgggcgacctcaagga	Protospacer
 .*  ***** **************** **** * 

63. spacer 4.1|1249067|35|NC_015125|CRT matches to ASHF01000034 (Streptomyces sp. GBA 94-10 plasmid pGBA1, complete sequence, whole genome shotgun sequence) position: , mismatch: 8, identity: 0.771

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
ccccgcgtcgtcggcctcgtgggcgacctcaagga	Protospacer
 .*  ***** **************** **** * 

64. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP029339 (Streptomyces sp. SM17 plasmid pSM17A, complete sequence) position: , mismatch: 8, identity: 0.771

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
ccccgcgtcgtcggcctcgtgggcgacctcaagga	Protospacer
 .*  ***** **************** **** * 

65. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP026489 (Streptomyces sp. 604F plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.771

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
ccccgcgtcgtcggcctcgtgggcgacctcaagga	Protospacer
 .*  ***** **************** **** * 

66. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013526 (Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

67. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013556 (Rhizobium phaseoli strain N931 plasmid pRphaN931d, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

68. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013589 (Rhizobium phaseoli strain N161 plasmid pRphaN161d, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

69. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013579 (Rhizobium phaseoli strain N671 plasmid pRphaN671e, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

70. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013536 (Rhizobium phaseoli strain R650 plasmid pRphaR650d, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

71. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013541 (Rhizobium phaseoli strain R630 plasmid pRphaR630d, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

72. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013546 (Rhizobium phaseoli strain R620 plasmid pRphaR620d, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

73. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013567 (Rhizobium phaseoli strain N831 plasmid pRphaN831d, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

74. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013573 (Rhizobium phaseoli strain N771 plasmid pRphaN771e, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

75. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013515 (Rhizobium sp. N1314 plasmid pRspN1314d, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

76. spacer 4.1|1249067|35|NC_015125|CRT matches to NZ_CP013605 (Rhizobium sp. N731 plasmid pRspN731d, complete sequence) position: , mismatch: 9, identity: 0.743

atcatcgtcgacggcctcgtgggcgacgtcaacgc	CRISPR spacer
atcatcggcggcggcctcgtgggcgtatcgattgc	Protospacer
******* **.**************   . * .**

77. spacer 4.2|1249121|35|NC_015125|CRT matches to NZ_CP033509 (Mesorhizobium jarvisii strain ATCC 700743 plasmid pMJ700743b, complete sequence) position: , mismatch: 9, identity: 0.743

gtgcaggtgcgggagctcgaaggctccctgagcgc	CRISPR spacer
gtgcgggtgcgggaggtcgaaggctggatacggtc	Protospacer
****.********** *********   *. *  *

78. spacer 4.2|1249121|35|NC_015125|CRT matches to NZ_CP033370 (Mesorhizobium loti strain SU343 plasmid pMLSU343b, complete sequence) position: , mismatch: 9, identity: 0.743

gtgcaggtgcgggagctcgaaggctccctgagcgc	CRISPR spacer
gtgcgggtgcgggaggtcgaaggctggatacggtc	Protospacer
****.********** *********   *. *  *

79. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NC_019848 (Sinorhizobium meliloti GR4 plasmid pRmeGR4c, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

80. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NC_017327 (Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

81. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP021798 (Sinorhizobium meliloti strain USDA1106 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

82. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP009145 (Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaatt	Protospacer
 ** .  **********. *************.. 

83. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP021801 (Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

84. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP021830 (Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaatt	Protospacer
 ** .  **********. *************.. 

85. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP021824 (Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaatt	Protospacer
 ** .  **********. *************.. 

86. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP021794 (Sinorhizobium meliloti strain USDA1157 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

87. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP021809 (Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

88. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP021217 (Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

89. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NC_003037 (Sinorhizobium meliloti 1021 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

90. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP019585 (Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaatt	Protospacer
 ** .  **********. *************.. 

91. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NC_017324 (Sinorhizobium meliloti BL225C plasmid pSINMEB01, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

92. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP021827 (Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaatt	Protospacer
 ** .  **********. *************.. 

93. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NC_018683 (Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

94. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP021805 (Sinorhizobium meliloti strain T073 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

95. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP026526 (Sinorhizobium meliloti strain AK21 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

96. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP019483 (Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

97. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NZ_CP019486 (Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

98. spacer 18.1|3431140|35|NC_015125|CRISPRCasFinder matches to NC_020527 (Sinorhizobium meliloti 2011 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.714

tgtcgaggggtgcggtggcttcggcgggctcagcg	CRISPR spacer
ggtaatcgggtgcggtgaattcggcgggctcaata	Protospacer
 ** .  **********. *************...

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	1135351 : 1142696	7	Pandoravirus(33.33%)	protease,tRNA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_015125|1135351:1142696|DBSCAN-SWA
ATCAGGCCTCCCAGGCGCGGGCGACGGCGAGCGCGTCGCGGGTGGTCGGAACATCGTGCACGCGGACGGCCCACGCGCCGGACCGCGCGGCCAGCGCACTCGTGACGGCGGTCGCGAGGTCGCGGCGGGTGAGATCGGCGTCCTCGCCAAGCACCTCGGCGAGGAAACGCTTGCGACTGGTGCCGATCAGCACGCGGGATCCGAGCGCGGCGAGGGTGGGGATCGCGTTCAGAACCCGCCAGTTCTGGATGCCACGCTTCCCGAAGCCCACACCCGGGTCGACGATGATGCGGTCCGAGGCGATTCCCGCGGCGCGGGCCGCCGCCACCCGTTCGGCCAGCTCGTCGGCGACCTCTCGGCCCGCGTCGGCGTAGTCGGCGCGCGCGTACATGTCGGAGGAGGGACCGCGCCAGTGTCCCAGGGCGATCTCCGCGTCGGTCTCGGCGACCGCGGCGAGCATCTCGGGATCGGCGAGACCTCCCGACACATCGTTGACGAGGCGCGCGCCCGCGGCGACCGCGGCGCGCGCCGTCGAAGCGTTCATCGTGTCGATGCTGACGACGGCCCCCTCGGATGCCAGCGCCTCGACGACCGGCAGAACGCGCTGCTGCTCCACCCGAGGGGCGACGCGCTCGGCACCCGGCCGCGTGGACTCGCCCCCGATGTCGAGGAGGTCCGCCCCTTGGGCGCGCAGGGAGCGCGCGTGTGCGATCGCCACGTCGGGGTCGAGGTAGCGCCCGCCGTCGCTGAAGGAGTCCGGGGTCACGTTGACGATCGCCATGATGAGGGTCACGCTCGTGCCCCGATCAGGGCGACGAGCTCGGCCCGGGCGACGGCGTCGGTGTACGCGCCGCGCGCGGCGATCGTGACGGTCGACGCGTCGAGCTGGCGGCCGCCGCGCATGGTCACGCACTCGTGGACGGCGTCGAGCACCACGAGAACACCCCGCGCATCGAGAGCGGATGCCACGGCGTCGGCGACCTGCTCACCGAGCCGCTCCTGCACCTGAGGGCGTGCCGCCAGGATGTCGATCACCCGGGGCAGCGCTCCGAGACCCACGACCTCTTCCCCGGGCAGATACGCCACATGGGCACGCCCGCGGAAAGGGAGGAGATGGTGCTCGCACATCGAGCGGAAGGCGATGTCCCGCAGCATCACGGCACCGGACGGAAGGGTGTCCGGCGCCGGTCCGCGCGTCACCGAGATGGTGTGCTGCAGGGGGGCGGTGGCATCCTGACCCACTCCGCCGAAGAACTCGCTCCACGAATCGGCCACGCGGGTCGGCGTCTGGCGGAGCCCGGGGCGATCGGGATCCTCCCCGATCGCCTCGAGCAACTCGCGTACGAGCGCGGCGACGCGCTCCCGGTCGACGGCCACGGCGCCTTAGGCCGTGGCCGGTCGCGTCTGTCCGCTCGGGCGGCGCTGCGCCTGCGTCGCGGTCTGCGCCTCGGACTCCACCGACGCGGCCACGCCGGCCGGGGCCGAGCGACGGGGAACGTCGACGGGAGGCAGGGTCGAGACCGGACGGTCGCCGGACGACAGCCACTGGGGACGCGGCGGGAGGCGCTTGACGTCCTTGAAGATCTCGGCGAGCTCGAGATGGTCGAGCGTCTCCTTCTCGAGCAGCTCGAGAGCAAGACGGTCGAGGACGTCGCGGTTGGCGTTGATGACCTCGTACGCCTCGTTGTGCGCCTGCTCGATGAGCGCGCGCACCTGGGCGTCGACGCGCTCGGCGATGCGCTCCGAGAAGTCACGGCCGTGACCCATGTCGCGGCCCATGAAGACCTCGCCCGACGAGGAGCCGAGCTTGACCGGGCCCACGTCGTTGGTCATGCCGTACTCGGTGACCATCTTGCGGGCGATGCTCGTCGCCTTCTCGATGTCGTTCGAGGCGCCGGTGGTGGGGTCGTGGAACACGATCTCCTCGGCCACGCGGCCGCCCATCGCGTACGTCAGCTGGTCCTGCAGCTCGTTGCGGGTGACCGAGTACTTGTCGTCGAGCGGCAGCACCATCGTGTACCCGAGCGCCTTGCCGCGCGGAAGGATCGTCACCTTCGTGACGGGGTCGGTGTGGTTCATCGCCGCCGCGGCGAGCGCGTGTCCGCCCTCGTGGTAGGCCGTGATGAGCTTCTCTTTGTCCTTCATCACGCGGGTACGGCGCTGGGGACCGGCGATGACGCGGTCGATGGCCTCGTCGAGCGCGCGGTTGTCGATGAGCTGCGCGTTCGAGCGCGCCGTCAGCAGGGCCGCCTCATTGAGGACGTTCGCGAGATCGGCACCGGTGAAGCCGGGCGTCTTACGCGCGACGACCTCGAGGTCGACCGAGTCGGACAGCGGCTTGCCGCGACCGTGCACCTCGAGGATGCGCTGGCGTCCCTTGAGGTCGGGGGCGTCGACACCGATCTGACGGTCGAACCGGCCCGGACGCAACAGGGCGGGGTCGAGGATGTCGGGGCGGTTCGTCGCCGCGATGACGATGACGTTGACCTTCGGGTCGAAGCCGTCCATCTCGACGAGCATCTGGTTCAGCGTCTGCTCGCGCTCGTCGTGCCCGCCGCCCATGCCGGCGCCGCGGTGGCGACCGACGGCGTCGATCTCGTCGATGAAGATGATGGCCGGCGAGCTCTCCTTGGCCTGGTTGAAGAGGTCGCGGACGCGGCTGGCGCCGACACCGACGAACATCTCGACGAAGTCCGAACCCGAGATCGAGTAGAACGGCACCCCGGCCTCGCCGGCGACGGCGCGGGCGAGCAGGGTCTTACCGGTTCCGGGAGGGCCGTACAGCAGCACGCCCTTCGGGATGCGGGCACCGACCTCTTCGAACTTCTTCGGATCCTTGAGGAACTCCTTGATCTCGTCGAGCTCTTCGATCGCCTCGTCGGATCCCGCGACGTCCTGGAAGGTGACGGTCGGCGTCTCCTTCGTCACGAGTTTCGCGCGCGATTTGCCGAACTGCATGACCTTGCTGCCGCCGCCCTGGGCGCTCGAGAGCAGCCACCAGAAGAGAAGGCCGAGCAGCACGAGCGGGATCATCAGCCCGAGGAAACCGTCGAACCAGCTGGGCTTGGGGACGACGTCGTTGAAGCCGTCCGAGGGAGCGGCGCTGTCGATCGCGCTGGCGACCTCGTTCGCACGAGCCTGGCTGTAGTAGAACTGCACGTCGTTCGCACCCTCGAACGGCTGCGACAGCGTGAGGTCGACGCGCTGATCGGGATCGTTGGTCACCACCTGGGTGACGGTCCCGCCCTTCAGCAGGTCGAGACCCTCTTTCGTGGAGATCTGACGTGCACCGCTCAGGTTCGAGATGAGCGAGAAGCCGATGACCAGAAGCAGACCGACCAGCAGAACGTAGATGATCGGGTTGCGCGTGATCTTCTTGAAATCCATGGTGGGCAAGCCCAGCCCTTTCGTGAACCGCTCGCGGAGGAAAAGCGGTGGGATCAGGGTAACGCCCGCGGACTATGCCGGGCCTGTGCGTTCGTCGTGGGCGTATCCGGGGGTCAGGAGTACACGTGCGGCGCGAGCACCGCGACGTCGCGCAGGTTGCGGTACTTCTCCGCATAGTCGAGTCCGTACCCGATGACGAAGTCGTTGGGGATGTCGAAGCCCACGTAGCGGCACTCGACCTCGACCTTCATGGCATCCGGTTTGCGCAGGAGCGCCAGCACCTCGACCGATTCGGCTCCGCGCGAGGCGAAGTTCTCGAGCAGCCAGCTGAGCGTGAGGCCGGAGTCGATGATGTCCTCGACGATCAGCACGTGCTTGCCGGTGATGTCGGTGTCGAGGTCTTTGCGGATCTGCACGACGCCGCTCGAGCGCGTGCTCGCGCCGTAGGAGGACACGGCCATCCAGTCCATCGTGATGTGCCGGGGCAGGTGACGCGCGAAGTCGGCCATCACCATGACCGCCCCCTTGAGGACTCCCACGAGCACGACGTCTTTGCCGGAATAGTCGGCGACGACCTGCTGCGCCAATTCGGCGAGCTTCTCGTGAATCTGTTCCTCGGTGAGGAGGACTTCGCTGATGTCGTCGGAAATGTCGGCCGCGCGCATTCGGAAAGTCTACGTCGGTCGATTCAGGATGCCGCCCGCGCGACGACCTCGATCCGCCCGCCGGCGCGGCGCGCGAGGCATCCGGGCAGATCGATCGGGCCCTGACCCCGCCAGTCCGTCGCGAGGCGCGCGACCTCGAGTGTCTGCGTGCGCGTGAGGGAGACCCCGAACTCGCTCTCGACGACGTATCGCACGATGCGGTTGCGCAGCGCCGCGGGGTTCGCCGCCAGCGCCGCAGCCGAGAGCGAGATGCCGGCCTCGGCGTGCTCGACGATGTCTTCGATCGTCTCGTCGATCATGTCCTGGAACGCGGCGGCATCCTCGCGCAGTTGCTCGGCCGTACGGGCGAGGGCCTCGGCGACCCCCGGTCCGAGTTCCGCCTCGAGCACCGGCAGCACGCGCTCGCGCACCCGCACGCGCGTGTATGCGGGGTCGGCGTTGTGCGGGTCGGTCCACGGGTCGAGCCCCTCCGCGGCACAGGCGGCGACGGTAACCCGGCGGCGCACGGCGAGGAGCGGGCGCACCCACGTCGGGCCGGTGGCATCCCGTCGCTCCGGTGCCATGCCGGAAAGACTCGCCGCACCGGCTCCGCGCGCCAGCCCCAGAAGCACCGTCTCCGCCTGGTCGTCGAGGGTGTGGCCGAGCAGCACCGCGTCAGCGCGGATGTCGGCCGCCGCGCGCGCGAGACCGGCATAGCGCGCTTCCCGCGCAGCAGCCTCGGGGCCGTCACCTGAACCGACCTGCACCGTCACGACGCGCGCATCGAGACCGAGAGCGCGCGCCTTCTCCGCGGCCGCGGCGGCGACGGCATCCGACCCGTCCTGCAATCCGTGGTCGATCACGACGGCCTCGGCACGGATGCCGGCACGGGGCGCCTCGAACGCGGTCGCGGCCGCGAGCGCGAGCGAATCCGGCCCGCCCGACAGCGCGACGACGACGGAGCCGTCGATCCGCTCGAGCGCCGCGCGCACGGCACGACGCACCTCGGCGACGGACGGGTCGAGTCCGGGACGGTGATCCATCCCTCCACGGTAGCGGCGTCACGGCTCGGGCTCCGGGTGGCTCCCGACTAGGCTGGGCGCGGAAATCCACAGATCTAAGGAGCACGAGTATGGGCGCATACGACGCCGTCATCGAGATCCCCCGCGGCAGCCGCGTGAAGTACGAGGTCGACCACGGCACCGGCCGCGTCTACCTCGACCGCATCCTCTACACGGTGTTCGGCTACCCGGCCAACTACGGCTTCTTCGAGAACACCCTCGGCGAAGACGGCGACCCGCTCGACGTGCTCGTGCTGCTCGACCGCGAGCTGCACCCCGGCATCCTCGCCAAGGTGCGTCCCGTCGGCGTGCTCAAGATGAGCGACGAGGCCGGCGGCGACGACAAGGTCGTGGCCGTGCTCGCGAAGGACCCGCGTTGGGACCACATCCAGGACGTCGGCGACATCGACGAGTGGACGAAGAAGGAGATCACGCACTTCTTCGAGCACTACAAGGACCTCGAGCCCAACAAGTGGGTCAAGGTCGACGAGTGGGCGGATGCCGCCGAGGCCGAGCGCCTGGTCGGCGAGGCGTTCACGCGCTTCGACGAGCACGACGCGCAGACCAAGACGCAGGGCTCGGGCGAGGCGCCGAACACGCTCTGACACCCTCGCGTCAACGAAAGAACCCCCGGTCTCGGACCGGGGGTTCTTTCGTGTCAGACGTCGATTCCGCGCCAGCGCAGCCAGGGCGCCGGATCGGTGGTGCCGCCCCACGGCGGGTAGACCTCGAAGTGGAGGTGGCAGCCGAACGAGTTGCCCGTCTGCCCCGCGGCGGCGATCTGCTGCCCCGACGAGACCCAGTCGCCGGTCGACACGTAGATGCCGCCGTTGACGATGTGGGCGTAGCCCGTGCCCGAGCCGTCGGGGTGCTCGATGCGGATGTAATTGCCGTAGCCGCCGTTGTATCCGGCGTAGCTCACGCGGCCGTCGAAGGCCGCGTAGATCGGCGAGTAACACCCGGCGCCGAAGTCGAGGCCGAGGTGCCACGAGCTCGCGCAGTAGCTACCGTTGCACTGGCTCGAGCGCGGCCCGTAACCCGAGGTGGTGCCGGCCCACGAGGGACGGGACCACCCACCGGGCCCTCCGCCGCCGCCGCTGTTTCCGCCGCCACCGCCGCCGCCGTTGTCTCCACCGCCGCCGCCACCGCTGTTGTTGTTGGCGTTGTCGCGTTCTTCCTGCTCACGACGCTCGCGTTCGGCTCGGTCGCGCGCTTCCGCTTCCTCGCGTGCTTTCCGCTCGCGCTCTTCACGCGCCTTGCGCTCGGCCTCGACGCCGGCCTGGTAGTCGGCGACCGTCTTCGCGGTCGTGTCCTGGAGGGCGGCGAGCTGCGCTTCGAGGGTCGCCTGGTTCTCCTGCTGTGCCGCCAGGGCCTGCTGAGCGGCGTCGGCGGCCTGCTGAGCGGCGACCATCTTCTCTTGCGCGATCTTCTGCAGCCGGTCGCGCTCGGCGCGCGCGTCGTTCGCCTGGTTGCTCAGGTTCTTCGCGTTGTCGCGAGCCGTGACCGCCGCGGCGTACACGGCGCGGTTGCGATCGACGAGCTTGTCCATCGTGCCGAGCTTGGCGAGCAGATCGTCCGCGGTCGCGGCCGAGCCGGAGAAGAACAGATCGAGGGAGGTGTCATCGCCGCCGTCGCGGTACAGCTGTGCGGCGACCTTGCCGGCCTTGGTCGCGGCATCCGTGGCCTTCTGCGCCTCGGCGTCGGCCTGCGACTGGATCTGCTGAGCGCGGTAGTCCGCGTCGAAGTAGGCCTGCTGAGCGGTGTAGTACTCGTCGGAGCGGGCGACGACCTCGGCCTGCGTGCGCGCGACCTCGGACTGCAGTTGCTGGATCAGGCCCTGGATGCGGGTGATCTCACCCGCTTTCGCGGCTTCGTTCGCGCGCGCGGCTTCGACGTCGTCCCACGAGGGGTAGTCGGCGGCGTACGCGGGTGATCCGAACGACGGCACCGTCGCGCCGAAGGCGCCGACCGCCACGGCCCCCAGGGCTCCCAGCTTCAGCGCGCTCCGTCGGTCGAGCGACGGCCACAGGCGACGCCTCTCACTCTCGGAGGGCGCGCAACCGCAGTCGTCGTGATCTTCGGGGCGCTCGAGCGTCACGGGAATACCTTCTCTCACCGGTTCGCAACTCGGAACACAGTAGCAACACGAGTCACAGGAGCAACAGAGCGAGTCCCGCCGTTGCGGCCCATCTTCCGTCGCCGAACCCGCTTCGGCACGTACGCCACGCCCTCGATTGGCAATCTCGCGAATCAT

Protein sequences of DBSCAN-SWA_1

>NC_015125|1135351:1142696|1135351_1136143_-|WP_013584169.1|DBSCAN-SWA
MTLIMAIVNVTPDSFSDGGRYLDPDVAIAHARSLRAQGADLLDIGGESTRPGAERVAPRVEQQRVLPVVEALASEGAVVSIDTMNASTARAAVAAGARLVNDVSGGLADPEMLAAVAETDAEIALGHWRGPSSDMYARADYADAGREVADELAERVAAARAAGIASDRIIVDPGVGFGKRGIQNWRVLNAIPTLAALGSRVLIGTSRKRFLAEVLGEDADLTRRDLATAVTSALAARSGAWAVRVHDVPTTRDALAVARAWEA
>NC_015125|1135351:1142696|1136139_1136727_-|WP_013584170.1|DBSCAN-SWA
MAVDRERVAALVRELLEAIGEDPDRPGLRQTPTRVADSWSEFFGGVGQDATAPLQHTISVTRGPAPDTLPSGAVMLRDIAFRSMCEHHLLPFRGRAHVAYLPGEEVVGLGALPRVIDILAARPQVQERLGEQVADAVASALDARGVLVVLDAVHECVTMRGGRQLDASTVTIAARGAYTDAVARAELVALIGARA
>NC_015125|1135351:1142696|1141100_1142696_-|WP_080575362.1|DBSCAN-SWA
MIREIANRGRGVRAEAGSATEDGPQRRDSLCCSCDSCCYCVPSCEPVREGIPVTLERPEDHDDCGCAPSESERRRLWPSLDRRSALKLGALGAVAVGAFGATVPSFGSPAYAADYPSWDDVEAARANEAAKAGEITRIQGLIQQLQSEVARTQAEVVARSDEYYTAQQAYFDADYRAQQIQSQADAEAQKATDAATKAGKVAAQLYRDGGDDTSLDLFFSGSAATADDLLAKLGTMDKLVDRNRAVYAAAVTARDNAKNLSNQANDARAERDRLQKIAQEKMVAAQQAADAAQQALAAQQENQATLEAQLAALQDTTAKTVADYQAGVEAERKAREERERKAREEAEARDRAERERREQEERDNANNNSGGGGGGDNGGGGGGGNSGGGGGPGGWSRPSWAGTTSGYGPRSSQCNGSYCASSWHLGLDFGAGCYSPIYAAFDGRVSYAGYNGGYGNYIRIEHPDGSGTGYAHIVNGGIYVSTGDWVSSGQQIAAAGQTGNSFGCHLHFEVYPPWGGTTDPAPWLRWRGIDV
>NC_015125|1135351:1142696|1140513_1141047_+|WP_013584174.1|DBSCAN-SWA
MGAYDAVIEIPRGSRVKYEVDHGTGRVYLDRILYTVFGYPANYGFFENTLGEDGDPLDVLVLLDRELHPGILAKVRPVGVLKMSDEAGGDDKVVAVLAKDPRWDHIQDVGDIDEWTKKEITHFFEHYKDLEPNKWVKVDEWADAAEAERLVGEAFTRFDEHDAQTKTQGSGEAPNTL
>NC_015125|1135351:1142696|1136733_1138737_-|WP_043361051.1|protease|DBSCAN-SWA
MDFKKITRNPIIYVLLVGLLLVIGFSLISNLSGARQISTKEGLDLLKGGTVTQVVTNDPDQRVDLTLSQPFEGANDVQFYYSQARANEVASAIDSAAPSDGFNDVVPKPSWFDGFLGLMIPLVLLGLLFWWLLSSAQGGGSKVMQFGKSRAKLVTKETPTVTFQDVAGSDEAIEELDEIKEFLKDPKKFEEVGARIPKGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFNQAKESSPAIIFIDEIDAVGRHRGAGMGGGHDEREQTLNQMLVEMDGFDPKVNVIVIAATNRPDILDPALLRPGRFDRQIGVDAPDLKGRQRILEVHGRGKPLSDSVDLEVVARKTPGFTGADLANVLNEAALLTARSNAQLIDNRALDEAIDRVIAGPQRRTRVMKDKEKLITAYHEGGHALAAAAMNHTDPVTKVTILPRGKALGYTMVLPLDDKYSVTRNELQDQLTYAMGGRVAEEIVFHDPTTGASNDIEKATSIARKMVTEYGMTNDVGPVKLGSSSGEVFMGRDMGHGRDFSERIAERVDAQVRALIEQAHNEAYEVINANRDVLDRLALELLEKETLDHLELAEIFKDVKRLPPRPQWLSSGDRPVSTLPPVDVPRRSAPAGVAASVESEAQTATQAQRRPSGQTRPATA
>NC_015125|1135351:1142696|1139425_1140424_-|WP_013584173.1|tRNA|DBSCAN-SWA
MDHRPGLDPSVAEVRRAVRAALERIDGSVVVALSGGPDSLALAAATAFEAPRAGIRAEAVVIDHGLQDGSDAVAAAAAEKARALGLDARVVTVQVGSGDGPEAAAREARYAGLARAAADIRADAVLLGHTLDDQAETVLLGLARGAGAASLSGMAPERRDATGPTWVRPLLAVRRRVTVAACAAEGLDPWTDPHNADPAYTRVRVRERVLPVLEAELGPGVAEALARTAEQLREDAAAFQDMIDETIEDIVEHAEAGISLSAAALAANPAALRNRIVRYVVESEFGVSLTRTQTLEVARLATDWRGQGPIDLPGCLARRAGGRIEVVARAAS
>NC_015125|1135351:1142696|1138850_1139402_-|WP_013584172.1|DBSCAN-SWA
MRAADISDDISEVLLTEEQIHEKLAELAQQVVADYSGKDVVLVGVLKGAVMVMADFARHLPRHITMDWMAVSSYGASTRSSGVVQIRKDLDTDITGKHVLIVEDIIDSGLTLSWLLENFASRGAESVEVLALLRKPDAMKVEVECRYVGFDIPNDFVIGYGLDYAEKYRNLRDVAVLAPHVYS

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013584169.1|1135351_1136143_-	dihydropteroate synthase	A0A0B5J4J5	Pandoravirus	7.7e-22	34.1
WP_013584170.1|1136139_1136727_-	GTP cyclohydrolase I	A0A0B5J000	Pandoravirus	7.5e-30	44.6
WP_043361051.1|1136733_1138737_-|protease	ATP-dependent zinc metalloprotease FtsH	G9E6G3	Micromonas_pusilla_virus	2.4e-104	40.7
WP_013584172.1|1138850_1139402_-	hypoxanthine phosphoribosyltransferase	A0A1V0SEQ1	Hokovirus	1.8e-09	29.2
WP_013584173.1|1139425_1140424_-|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_013584174.1|1140513_1141047_+	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	1.6e-31	45.2
WP_080575362.1|1141100_1142696_-	M23 family metallopeptidase	A0A2D0ZM66	Rhodococcus_phage	4.7e-10	39.4