CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014391	Micromonospora aurantiaca ATCC 27029, complete sequence	9 crisprs	csa3,cas3,DEDDh,WYL,PD-DExK,RT,cas4,c2c9_V-U4,DinG	1	2	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014391_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014391_1

218385-218483

Orphan

Consensus_repeat	Method
CCGCCCTGCTGGCCGTAACCGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014391_1

>merge|NC_014391|1|218385-218483|CRISPRCasFinder
GGCGGCTCCTGGCCGTAACCGCCCTGCTGGCCGTAACCGCCCTGCGGGTTCTGACCGTAGCCCTCGCCGTACCCGCCGCCCTGCTGGCCGTAGCCGCCC

>NC_014391|1|1|218385-218483|CRISPRCasFinder
GGCGGCTCCTGGCCGTAACCGCCC	TGCTGGCCGTAACCGCCCTGCGGGTTCTGACCGTAGCCCTCGCCGTACCCG
CCGCCCTGCTGGCCGTAGCCGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014391.1\|WP_013283423.1\|217423_218173_+\|2-phosphosulfolactate-phosphatase	unknown	unknown	gnl\|CDD\|224956
NC_014391.1\|WP_013283422.1\|214701_217413_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	unknown	unknown	gnl\|CDD\|234921
NC_014391.1\|WP_007073996.1\|228411_228621_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|133390
NC_014391.1\|WP_013283417.1\|210423_211848_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|176471
NC_014391.1\|WP_013283430.1\|226057_227140_-\|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
NC_014391.1\|WP_013283419.1\|212539_213223_-\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|238113
NC_014391.1\|WP_013283431.1\|227315_228155_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013283432.1\|228692_229085_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274712
NC_014391.1\|WP_013283428.1\|225187_225400_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013283426.1\|222833_223988_+\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NC_014391.1\|WP_013283415.1\|209076_209592_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NC_014391.1\|WP_013283420.1\|213693_213957_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl\|CDD\|376904
NC_014391.1\|WP_013283421.1\|213953_214637_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	unknown	unknown	gnl\|CDD\|235140
NC_014391.1\|WP_013283416.1\|209588_210335_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013473444.1\|220661_221090_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380033
NC_014391.1\|WP_013283414.1\|207690_208983_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|236440
NC_014391.1\|WP_174361687.1\|211951_212527_-\|heavy-metal-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|376657
NC_014391.1\|WP_013283429.1\|225550_225766_-\|DUF3073-domain-containing-protein	unknown	unknown	gnl\|CDD\|378620
NC_014391.1\|WP_174361756.1\|224115_225207_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|211984
NC_014391.1\|WP_013283425.1\|221258_222776_+\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236113

Protein	Function_ID	Function_description	E-value
NC_014391.1\|WP_013283423.1\|217423_218173_+\|2-phosphosulfolactate-phosphatase	gnl\|CDD\|224956	COG2045, COG2045, Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only].	8.74828e-20
NC_014391.1\|WP_013283422.1\|214701_217413_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	gnl\|CDD\|234921	PRK01213, PRK01213, phosphoribosylformylglycinamidine synthase subunit PurL.	0
NC_014391.1\|WP_013283417.1\|210423_211848_+\|adenylosuccinate-lyase	gnl\|CDD\|176471	cd03302, Adenylsuccinate_lyase_2, Adenylsuccinate lyase (ASL)_subgroup 2. This subgroup contains mainly eukaryotic proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP). ASL deficiency has been linked to several pathologies including psychomotor retardation with autistic features, epilepsy and muscle wasting.	1.64881e-178
NC_014391.1\|WP_013283430.1\|226057_227140_-\|Glu/Leu/Phe/Val-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	3.58112e-94
NC_014391.1\|WP_013283419.1\|212539_213223_-\|trypsin-like-serine-protease	gnl\|CDD\|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	8.01041e-26
NC_014391.1\|WP_013283432.1\|228692_229085_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274712	TIGR03666, Rv2061_F420, PPOX class probable F420-dependent enzyme, Rv2061 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	7.10406e-48
NC_014391.1\|WP_013283426.1\|222833_223988_+\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	0
NC_014391.1\|WP_013283415.1\|209076_209592_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	1.55292e-36
NC_014391.1\|WP_013283420.1\|213693_213957_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl\|CDD\|376904	pfam02700, PurS, Phosphoribosylformylglycinamidine (FGAM) synthase. This family forms a component of the de novo purine biosynthesis pathway.	1.49681e-30
NC_014391.1\|WP_013283421.1\|213953_214637_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	2.3952e-137
NC_014391.1\|WP_007073996.1\|228411_228621_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|133390	cd04762, HTH_MerR-trunc, Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins. Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.	7.10039e-16
NC_014391.1\|WP_013473444.1\|220661_221090_+\|hypothetical-protein	gnl\|CDD\|380033	pfam17844, SCP_3, Bacterial SCP ortholog. This domain is found in MSMEG_5817 gene product from M. smegmatis. It has been shown to be vital for mycobacterial survival within host macrophages. Crystal structure revealed a Rossmann-like fold alpha/beta two-layer sandwich forming a highly hydrophobic interface cavity and with high structural homology to the SCP family. Hence, it has been suggested that this domain may be involved in the interaction of apolar ligands through its hydrophobic cavity. Alanine-scanning mutagenesis of the hydrophobic cavity of MSMEG_5817 protein demonstrated that the conserved Val82 residue plays an important role in ligand binding.	7.74632e-49
NC_014391.1\|WP_013283414.1\|207690_208983_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|236440	PRK09268, PRK09268, acetyl-CoA C-acetyltransferase.	0
NC_014391.1\|WP_174361687.1\|211951_212527_-\|heavy-metal-binding-domain-containing-protein	gnl\|CDD\|376657	pfam01906, YbjQ_1, Putative heavy-metal-binding. From comparative structural analysis, this family is likely to be a heavy-metal binding domain. The domain oligomerizes as a pentamer. The domain is about 100 amino acids long and is found in prokaryotes.	3.81034e-33
NC_014391.1\|WP_013283429.1\|225550_225766_-\|DUF3073-domain-containing-protein	gnl\|CDD\|378620	pfam11273, DUF3073, Protein of unknown function (DUF3073). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.46183e-20
NC_014391.1\|WP_174361756.1\|224115_225207_+\|radical-SAM-protein	gnl\|CDD\|211984	TIGR04261, putative_arylsulfatase_regulatory_protein, radical SAM/SPASM domain protein, GRRM system. Members of this protein family are radical SAM/SPASM domain proteins (see pfam04055 and TIGR04085) related to anaeroboic sulfatase maturating enzymes and the peptide modification enzyme PqqE. Members are found primarily in Cyanobacteria adjacent to a short protein, ~150 residues, in which the last ~60 residues tends to be repetitive and highly glycine-rich (see TIGR04260). The arrangement suggests modifications to the repetitive C-terminal region by this radical SAM domain enzyme, but the purpose of this system on the whole is unknown.	4.72266e-84
NC_014391.1\|WP_013283425.1\|221258_222776_+\|amidophosphoribosyltransferase	gnl\|CDD\|236113	PRK07847, PRK07847, amidophosphoribosyltransferase; Provisional.	0

>NC_014391.1|WP_013283423.1|217423_218173_+|2-phosphosulfolactate-phosphatase
MAVFAQPGAGARFDWGLTGAAELGRVCAALVVVDVLSFTTAVEVAVSRGMRVHPFPWGEQAADYARRVGAVAAVGRRKTTAEHQWSLSPAALRAAPVVADLVLPSPNGSAISAAASATGVPVVAACLRNAPAVGRWLRTEGYGSKDAPVGVVAAGERWPDGSLRPCVEDQLGAACVLDALADVPGGLSVEAAMALAALASTPDVPAAVRGCVSGRELAEGGFAEDVTVATEVGVSDVVPVLRQGYFAPA
>NC_014391.1|WP_013283422.1|214701_217413_+|phosphoribosylformylglycinamidine-synthase-subunit-PurL
MTTHPDPALREPQGVVPQAGPTDDWALGVDTVPRAADSPEELQPYAELGLRDDEYDRIRHILGRRPTQAELAMYSIMWSEHCSYKSSKVHLRQFGEKAPPSDRLLAGIGENAGVVRVSDELAVTFKVESHNHPSFVEPYQGAATGVGGIVRDILAMGARPVAVMDPLRFGAADHPDTARVLPGVVAGVGGYGNCLGLPNIGGEVVFDPCYQGNPLVNALCLGVLPVDRLQKKDATGPGNIVVLMGAKTGRDGIGGVSVLASATFDEGSEQRRPSVQVGDPFMEKLLIEACLELYDAELVVGIQDLGGAGLTCALTETAASAGTGMRVWLERVPLREPSMEPHEILASESQERMLLVVSPDKLDAVLKTAEKWGVWATAIGEVTAPSADGQPGRLVVTWRDQLVVDVPPGSLVDDGPVYARPMREPADLILLQADRAETLPRPSTPEALRETVLRMIASPNLADKTWVTEQYDRYVLGNTVLAQPEDSGVIRIDERSGLGVALSVDGNGRYARLDPYHGTKLALAEAYRNVAVTGAKPIAVTNCLNFGSPEDPGVMWQFAEAVRGLADGCLELGIPVTGGNVSFYNQTGAAAIHPTPVVGVLGVLDDVADRVPIGFVPRPAGDHDQLFLLGETHVELSGSEWAWVTHEHLGGIPPQVDLARERQLAELLAEAARVGHLSSAHDLSDGGLAQSLVESALRRGVGARVVVPEHFAGGSMPFVFLFSESAGRVLVSVPRGHEKAFTALCAERGVPWEFIGVTDPASGGLEVHGQFRIGLDELREAHTGTLPRLFGAAEAARVEVEATRTGTTTVLPATAEQPVGVDPAAVDAEPIAKAGRDTPAADAEASAPAAAAEPEASAAASDEAEPAEGTATPAVDGNPAQDESAPADGSDAPAPGEPAPGQR
>NC_014391.1|WP_013283421.1|213953_214637_+|phosphoribosylformylglycinamidine-synthase-subunit-PurQ
MTARVGVVTFPGSLDDGDAARAVRIAGAEVVRLWHGDPDLHGVDAVVLPGGFSYGDYLRCGAIARFAPVMETIVQAARGGLPVLGICNGFQILCEAHLLPGALTRNQHLHFRNRDQVLRIESTGTAWTNAFQPGQEVLIPVKNGEGCYVADPATLDRLEGEGRVVARYVGGNPNGSQRDIAAITNEAGNVVGIMPHPEHAVEALTGPSLDGLGFFTSVLKHLVGAPA
>NC_014391.1|WP_013283420.1|213693_213957_+|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MPRVVVDVMLKPEILDPQGQAVANALPRLGVSDVASVRIGRRIEIEFTGEPDLDRAREIADKLLANPVIEDFTVHVVTADETAGAQS
>NC_014391.1|WP_013283419.1|212539_213223_-|trypsin-like-serine-protease
MRLRPLLAVLTTALAGVLATASGATAAPAGPQPIIGGGTVSSAPWAAAVFSNGSFTCSGSVIAPQWVLTARHCVSGTMSVRVGSVYYASGGVTRTVSASYTRYDLALLRLSSTVSTSAVSLASSNPPVGSTNTIYGWGMTCYSGCGASPQLKTASVRVTSTSVTDAYGGQAIRSTRVNGNAWRGDSGGPQFYNGRQVGVASTADGQSIQDYGSVAYNRAWITSTAGV
>NC_014391.1|WP_174361687.1|211951_212527_-|heavy-metal-binding-domain-containing-protein
MRRGSVGCGPAVRAAPFFSIRSAEHGSRTTRPGTDSIGSVLVVTTDQLPGYEIRQILGEVVSSMARTRNPYREGVKNLRGGAYDPMAPDNLTRWRTDSVARLGEEARRLGANAVIGMRFDSRDCGEMWMEICAYGTAVIVAPKMPDVMPPDQPAIAAETAHEPEIASAPGGIAEPASAPNLSSAAETPTGP
>NC_014391.1|WP_013283417.1|210423_211848_+|adenylosuccinate-lyase
MTTIPNVLANRYASPELVALWSPEEKVRMERRLWLAVLKAQRDLGVPVPDGVVEAYERVVDQVDLASIAARERVTRHDVKARIEEFSALAGHEHVHKGMTSRDLTENVEQLQIRASLELIRDRVVATLARLGWHAGEYSALVMTGRSHNVAAQATTLGKRFASAAEELLIAYERLEDLIGRYPLRGIKGPVGTAADQLDLFDGDAAKVAELEQRVAGHLGFRRVLDSVGQVYPRSLDFDVLSALAQVAAAPSSLATTIRLMVGQELVTEGFKPGQVGSSAMPHKMNTRSSERVNGFAVIIRGYLSMVGELAGDQWNEGDVSCSVVRRVALPDAFFAADGLFQTFLTVLDEFGPYPAVINRELERFLPFLATTKILVAAVRRGVGREVAHEVIKEHAVAVALAMREKGAAENDLFDRLAADGRLGLTRAEIDTLVADRNAFVGAATDQVARVTARITRVVESHPQAAAYSPPPIL
>NC_014391.1|WP_013283416.1|209588_210335_+|hypothetical-protein
MTYRQIFDEAIGDAPPTTVDVDALVAREGRRRRRTVGAYASATAVLALALGVGVVVQPGASGGPAPAHSAASAAARTEPERLRAAMLAAFHREAPDLRWVQGASTGDRETWDGPVTDEPPWWVQRLQWESATGWLAVGVAARGEVRSYLNINVGRVRPGHTSGPDRCRPGEVTCRSFTGPGGELVVAHDAEGRNLAKPVTKRTVLRTVTVKRADGAFVSVQTVSSTDRHLMTVEEMAAVALDPEIRLG
>NC_014391.1|WP_013283415.1|209076_209592_+|SigE-family-RNA-polymerase-sigma-factor
MTGRDEEFRDYVTARLEPLRRTAYLLCRDWHTADDLVSITLSKLYRNWRRALGADNLDAYVRGMLTNAWLDERRRPWRRERSTDEVPDRADLAAGEPSVGEREMLLELLGRLAPRRRAVVVLRFYCDLSVEETAQILGVSTGTVKSQAARALETLRLLASHHSAAESGRQR
>NC_014391.1|WP_013283414.1|207690_208983_+|acetyl-CoA-C-acetyltransferase
MQSVRRVAVIGGNRIPFARSNSRYAHASNADMLGAALDGLVARFGLAGERVGEMVAGAVLKHSRDFNLTREVVLGSRLDPHTPAYDIQQACGTGLEAAILVANKIALGQIEVGIAGGVDTTSDAPLAVNEDMRRTLIQLNSARTLGERLKIAAKLRPHQPFKPEIPRNAEPRTGLSMGEHAARTALRWNVDRAAQDELALRSHQRLAAAYDKGFFDDLMTPYLGLTRDQNLRPDTSLEKLGSLKPVFGASGADAERATMTAGNSSPLTDGASTVLLASEEWAKAHNLPVLAWFSWSEAAAVDFVHGDEGLLMAPAYAVPRMLARAGLSLQDFDFYEIHEAFASQVLATLAAWESPEFCKERLGLDAPLGSIDRDKLNVNGSSLAAGHPFAATGGRIVATLAKLLDQKGSGRGLISICAAGGQGVTAILER
>NC_014391.1|WP_013473444.1|220661_221090_+|hypothetical-protein
MPCLTGSSLPRAAVGRPSAGSYRPVVSSPHAYSEAVRAALVALDEGRTPERPVLREAVRTLLAALADRAPGRSVEVRVPPYGAVQCVSGPRHTRGTPPNVVEMDPPTWLAVATGRQGWAETVTEGRIRVSGNRADLSPYLPI
>NC_014391.1|WP_013283425.1|221258_222776_+|amidophosphoribosyltransferase
MPRGDGRLSHDLDPQRPGPQDACGVFGVWAPGEEVANLTYFGLYALQHRGQEAAGIAVSDGSGVVVYKDLGLVAQVFDEPTLASLRGHVAIGHARYSTTGGSTWENAQPTIRATTAGTTIALAHNGNLVNTAELQREAAVRGLDSDGSTNDTSLVTMLLASRPDLSVEAAALEVLPQLRGAFSFVFMDESTLYAARDAHGVRPLVLGRLERGWVVASETAALDIVGASVVREVEPGELIAIDENGLRSSRFASPEPKGCLFEYVYIARPDATIAGRNVHAARVQIGRQLAKEHPVEADLVIPVPESGTPAAIGYAEESGITYGQGLMKNPYVGRTFIQPSQTLRALGVRLKLNPLRQNVRGKRLVVVDDSIVRGTTQRAIVRLLREAGALEVHVRISSPPVSWPCFYGIDFATRAELLANGLDNDGIRRSIGADSLGYVSLPGLIAATEQPKSRLCRACFDGEYPIELPAGNLIGKHVLEGVGRRVAAEAAGPTGPLVATPTHHP
>NC_014391.1|WP_013283426.1|222833_223988_+|phosphoribosylformylglycinamidine-cyclo-ligase
MTHVSERSGAGSSPTGAGGDRQPWSAGSGRTQRKRSVSYADAGVSIEAGDRAVELLKSKVKETRRPEVMGDLGGFAGLFRLDTKKYKNPILASSTDGVGTKLVIAQQLDIHDTVGIDLVAMVVDDLVACGAEPLFLLDYIATGEVVPDKVAEIGAGIADGCRYAGCALLGGETAEHPGVLRPDEYDISATGVGVVEESEILSPERVEVGDVVIAMRSSGLHSNGYSLVRHVLLGAGRMRLDVVIDDFGRQRTLGEELLTPTKIYAQDCLKLIAEAEVRALAHVTGGGIPGNLVRVLPEHVDAVVNRSTWKPQPIFDLIQSKGRIEDPEMEATFNMGVGMFAIVSAEDADRALATLTGRGVDAWQAGEIIEGSGNVQMVGQHTRG
>NC_014391.1|WP_174361756.1|224115_225207_+|radical-SAM-protein
MRGISAVPSYVVMQPTTLCNLDCAYCYLPFRAVDRRMPVAVAEAVAASVNPWAAGGRFSVVWHGGEPLAAGREHLAALLAPFGPDVEHHVQTNATLIDDAWCAFFAEHRVRVSISVDGPRARNGERVTRGGRPAYDRIVAGVAALRRHGLPFSALAVVSRPEPGLATELYDYFLDLGCDVLGVNIEETEGVNTRTNARDEGAVTGFWAELVAAWRRDPRIHLREVEWSLRYAGAVLAGTADDLLPRSLDPIPTVGHDGSVVVLSPELAGFTDPRYGDFASGNVLTTPLGDILAGAAGTPWVGEFLTGVEACRASCAYFGFCGGGHAANRYFELGRFDGTETEHCRNSKIRLLEGVLEHARDHQ
>NC_014391.1|WP_013283428.1|225187_225400_+|hypothetical-protein
MPETISDTDREAVADRVRDAAAGLTALLREAEAARLLRAEVSGGDGADAVCAWNHFENIPTFYNWNNRPR
>NC_014391.1|WP_013283429.1|225550_225766_-|DUF3073-domain-containing-protein
MGRGRAKAKQTKVARELKYHSPNTDLTALQRELAGSGKSEHNFDDDYKEYVDDDDEDHADDDPDTWARPTR
>NC_014391.1|WP_013283430.1|226057_227140_-|Glu/Leu/Phe/Val-dehydrogenase
MGVFASTDDPVSTGHEQVVFCQDKQSGLKAIIGIYSTALGPALGGTRFYPYASEAEALADVLDLSRGMAYKNALANLDLGGGKAVIWGDPEQIKSEALLRAYGRFVEALNGRYYTACDVGTYVADMDVIARETRYVTGRSVEHGGAGDSSILTAWGVFQGMRAAAEHVWGSPTLAGRRVGVAGLGKVGKYLTAHLLDDGAEVVATDVSPRALEWARTTHPQVTLVDDTEALVTSDIDVYAPCALGGALNDDTVPVLRAKVVTGAANNQLAHPGIEKVLADRGILYTPDYVVNAGGVIQVADEIEGFNFDRAKLRATRIFDTTRQILQLADDEGVPPAVAADRLAERRMAEVGRLRTIHLR
>NC_014391.1|WP_013283431.1|227315_228155_+|hypothetical-protein
MPSLFASYLRVYEPLTAFDRDRQSYWRRYVSEGRAIAPLEGPVRQRTAVIEALGAGWTRLPDLPDEAYVLESDDALLVCPWNLRIRVAEAALSARDGVPSVLADAFVPPVLAGQAKAVVEDWRSGARVLEHGVPRVHEQIATWGVPLRWFVLFEAGERHLVTEPERRALRYRTEISKARRRASRALSVLRKSIGEAPITEAVEEAARWLEEFHPRSVVELDYGGLVQLLPDETLEADDSTELVATGLSGLGRGEAEEASAAYDKLVARWRAVQLLERCN
>NC_014391.1|WP_007073996.1|228411_228621_+|helix-turn-helix-domain-containing-protein
MASRTHEPEPLLTPAEVASMFRVDPKTVTRWAKAGKLSAIRTLGGHRRYRESEVRALLQGQIPQQRQGD
>NC_014391.1|WP_013283432.1|228692_229085_-|PPOX-class-F420-dependent-oxidoreductase
MTDLDRLAAEKYVLLTTFRKDGRAVPTPVWAVRDGDGLAVWTVADSGKVKRIRRDGRVTVAPCDVRGRPHGEAVPGHATIADPESTNRVRGLLKRKYRLIGRLSLLGSRLRRGERGTVGLRIVLDGPGRD

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Crispr_ID: NC_014391_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014391_2

1688263-1688355

Orphan

Consensus_repeat	Method
GCCGTACTGCGGCTGCTGCGGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014391_2

>merge|NC_014391|2|1688263-1688355|CRISPRCasFinder
GCCGTACTGCGGCTGCTGCGGCGGGTAGTCGCCGCCGTACTGCTGCTGGGGAGCCTGCGGGTAGTCACCGCCGTACTGCGGCTGCTGCGGCGG

>NC_014391|2|2|1688263-1688355|CRISPRCasFinder
GCCGTACTGCGGCTGCTGCGGCGG	GTAGTCGCCGCCGTACTGCTGCTGGGGAGCCTGCGGGTAGTCACC
GCCGTACTGCGGCTGCTGCGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014391.1\|WP_013284817.1\|1693527_1695087_+\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NC_014391.1\|WP_013284818.1\|1695174_1695990_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237871
NC_014391.1\|WP_013284807.1\|1679316_1680609_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|379140
NC_014391.1\|WP_013284808.1\|1680609_1681929_-\|peptidase-C39-family-protein	unknown	unknown	gnl\|CDD\|239109
NC_014391.1\|WP_013284822.1\|1699312_1700014_+\|chlorite-dismutase-family-protein	unknown	unknown	gnl\|CDD\|377705
NC_014391.1\|WP_013284811.1\|1684414_1686964_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371693
NC_014391.1\|WP_013284821.1\|1697906_1699316_+\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|237009
NC_014391.1\|WP_013284823.1\|1700109_1701210_-\|lytic-polysaccharide-monooxygenase	unknown	unknown	gnl\|CDD\|376983
NC_014391.1\|WP_013284806.1\|1678057_1679320_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|199834
NC_014391.1\|WP_013284816.1\|1691975_1693295_-\|ribonuclease-D	unknown	unknown	gnl\|CDD\|223426
NC_014391.1\|WP_174361774.1\|1676098_1677964_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|287142
NC_014391.1\|WP_013284810.1\|1683066_1684209_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_014391.1\|WP_013284819.1\|1696059_1696632_-\|DUF3000-domain-containing-protein	unknown	unknown	gnl\|CDD\|378665
NC_014391.1\|WP_174361702.1\|1696805_1697897_+\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NC_014391.1\|WP_013284804.1\|1674300_1676085_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224720
NC_014391.1\|WP_013284812.1\|1687209_1687596_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NC_014391.1\|WP_013284809.1\|1682377_1683046_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_014391.1\|WP_013284814.1\|1688615_1690679_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|236864
NC_014391.1\|WP_013284815.1\|1690675_1691872_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|273881
NC_014391.1\|WP_013284803.1\|1671075_1672266_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014391.1\|WP_013284817.1\|1693527_1695087_+\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	3.12748e-25
NC_014391.1\|WP_013284818.1\|1695174_1695990_+\|hypothetical-protein	gnl\|CDD\|237871	PRK14965, PRK14965, DNA polymerase III subunits gamma and tau; Provisional.	2.66213e-08
NC_014391.1\|WP_013284807.1\|1679316_1680609_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|379140	pfam13360, PQQ_2, PQQ-like domain. This domain contains several repeats of the PQQ repeat.	6.53814e-10
NC_014391.1\|WP_013284808.1\|1680609_1681929_-\|peptidase-C39-family-protein	gnl\|CDD\|239109	cd02549, Peptidase_C39A, A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature or have different domain architectures.	3.03563e-26
NC_014391.1\|WP_013284822.1\|1699312_1700014_+\|chlorite-dismutase-family-protein	gnl\|CDD\|377705	pfam06778, Chlor_dismutase, Chlorite dismutase. This family contains chlorite dismutase enzymes of bacterial and archaeal origin. This enzyme catalyzes the disproportionation of chlorite into chloride and oxygen. Note that many family members are hypothetical proteins.	3.84628e-102
NC_014391.1\|WP_013284811.1\|1684414_1686964_+\|hypothetical-protein	gnl\|CDD\|371693	pfam11721, Malectin, Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognizes and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan.	4.03888e-18
NC_014391.1\|WP_013284821.1\|1697906_1699316_+\|protoporphyrinogen-oxidase	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	4.89064e-125
NC_014391.1\|WP_013284823.1\|1700109_1701210_-\|lytic-polysaccharide-monooxygenase	gnl\|CDD\|376983	pfam03067, LPMO_10, Lytic polysaccharide mono-oxygenase, cellulose-degrading. This domain is found associated with a wide variety of cellulose binding domains. This is a family of two very closely related proteins that together act as both a C1- and a C4-oxidising lytic polysaccharide mono-oxygenase, degrading cellulose. This domain is also found in baculoviral spheroidins and spindolins, protein of unknown function.	5.58977e-45
NC_014391.1\|WP_013284806.1\|1678057_1679320_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|199834	cd10276, BamB_YfgL, Beta-barrel assembly machinery (Bam) complex component B and related proteins. BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.	1.48068e-08
NC_014391.1\|WP_013284816.1\|1691975_1693295_-\|ribonuclease-D	gnl\|CDD\|223426	COG0349, Rnd, Ribonuclease D [Translation, ribosomal structure and biogenesis].	6.76048e-81
NC_014391.1\|WP_174361774.1\|1676098_1677964_-\|hypothetical-protein	gnl\|CDD\|287142	pfam10131, PTPS_related, 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein. This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.	0.000197683
NC_014391.1\|WP_013284810.1\|1683066_1684209_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.85891e-46
NC_014391.1\|WP_013284819.1\|1696059_1696632_-\|DUF3000-domain-containing-protein	gnl\|CDD\|378665	pfam11452, DUF3000, Protein of unknown function (DUF3000). This is a bacterial family of uncharacterized proteins.	8.84307e-87
NC_014391.1\|WP_174361702.1\|1696805_1697897_+\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NC_014391.1\|WP_013284804.1\|1674300_1676085_+\|hypothetical-protein	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	0.00135712
NC_014391.1\|WP_013284812.1\|1687209_1687596_+\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	3.96424e-22
NC_014391.1\|WP_013284809.1\|1682377_1683046_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.2216e-70
NC_014391.1\|WP_013284814.1\|1688615_1690679_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|236864	PRK11154, fadJ, fatty acid oxidation complex subunit alpha FadJ.	1.37187e-114
NC_014391.1\|WP_013284815.1\|1690675_1691872_-\|thiolase-family-protein	gnl\|CDD\|273881	TIGR01930, 3-ketoacyl-CoA_thiolase, acetyl-CoA acetyltransferases. This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation. [Fatty acid and phospholipid metabolism, Other].	1.95183e-148

>NC_014391.1|WP_013284812.1|1687209_1687596_+|VOC-family-protein
MSAQIHCVTVETDDPYALAGWWARVLDRRLADDDHPGDPEAVLAAPDGHGPDLLFVRVDERHGKGAFHLDLHPAEGTRDEEVARLRELGAALVADRRRPDGTGWVVLADPEGNEFCVCRSPAERAASA
>NC_014391.1|WP_013284811.1|1684414_1686964_+|hypothetical-protein
MTHPSAPRRRRLLAVLTAGALTVAGLSPATPAAAVAAPGHDKVVHTVPSTASPDVQDGSVDAIHDAGTKIIAGGSFTRVQNRNSDVDIPRDYLLAFDKATGQVDTAFAPTLDNEVTAVVAGPTAGTVFVAGKFNTVNGVTRRKVALLDVATGAVVTSFTPPAFNGLIKDIALVGDRLLVGGIFTTAGNPNPRGGLASLNATTGAVDSYLTTALTENHNWDGVSGAKAGVGAEKLAVSPDGTQLVVIGNFKKADGVLHDQIVKIDLGATAATVADWNTARYTPRCKWQSFDSYVRDVAFSPDNSYFVVVTTGAPYGGTLCDTAARWEAGATGSSLQPTWVDYSGGDTFLSVGISEQAVYVGGHLRWLNNSTGTDNARAGAVGRASIAALDPANGLPLSWNPGRHPRGIGASEMLVTPSGLWVGGDTLWIGNFQYRRERIAFFPLAGGKAPHPTTTATLPGNVYQAGLPKPTNVLYRVNAGGPVVAAADGGPDWAADTGSSPSPYHNTGSSTSSFNTVGSLDATVPAGTPAALYSDERYDPAGGAEMLWQFPVPAGTEVHVRLYLANRYDGTSAPNTRVFDVALDGAVVLDDLDLSASVGHNVGTMREFTVTSDGTVDIEFRHVKENPLVDAVEIVKTGPPPAGTGEEVQVRSYDGLTGVGAPAPVANPDETAWSATRNAFWVGGTLFYGTGGALWRRTFDGTTFGTPELVDPYHDPYWDTVVTNSGPEGQTYVGATTGFYAEIPNVTGMFYTGGRLYYTLTGQNGLFWRWFTPDSGVVGADRFSVAGASGFSDAGAVFVAGSTLYKVNRSTGDLSAVDWVNGAPSGTFTVRSGPAVDGVDWRAKAVFVGP
>NC_014391.1|WP_013284810.1|1683066_1684209_+|HAMP-domain-containing-histidine-kinase
MRPTLRLRLTLLNGVLLVGAGAILVLLAWLLVRDALRPTDELLPGTTVVLTDGRTLDAGQWQRQLVDAASQELLVKGLLALVAISVVGVAGAYLVAGRALRPLHQVTATARRLGEATLDERIGWSGADDEVAELAETFDAMLDRISGAFEAQKRFVANASHELRTPLAVMRTEIDVTLSDDDADLAEYRRMAGVVRDASERANGLVDALLVLARSEAQTGRRLGRRAESDLAIGTANALSAVSREVERIGLKVHTSLRPAPVVGDPGLLDRLAGNLVENAVRYNHLHGRIWIRTGTDGERSWLVVGNTGFEVAPADVPGLFEPFRRGGQERTGARGSGLGLSIVRAVSDAHGGTVKAVAQPGGGLEVTVTLPSADPAAAT
>NC_014391.1|WP_013284809.1|1682377_1683046_+|response-regulator-transcription-factor
MRVLVVEDERNLADAIARGLRKRGMAVDVAYDGDAGHEAAFVTRYDVVILDRDLPGVHGDRICADLAASGALTRVLMLTASVTVADRVEGLQLGADDYLAKPFAFDELVARVQALGRRATPAAPPVLEVADLVLDPARRVVSRGGVPLDLTNKEFGVLAELLKARGAVVSSEELLERVWDANTDPFTTIVRVTVMTLRKKLGDPPLIDTVVGAGYRIGGVRQ
>NC_014391.1|WP_013284808.1|1680609_1681929_-|peptidase-C39-family-protein
MRRHGPPLQKTFGYAMLGGDDRQAQQAQVTAAPGGFPMSGRDIAYRRFRFPADRDRGRADGLRAGPDGLTLDGSAGRVTHTDPHSGTTAGYAAGTWTSPVTAVGFTVTELVPSWTADTPPGCWLRVGMRGWADGTAATGWYELGHWAADDSAVHRASVPGQEDDRARVAADTLRVTGATVTGWQVRVTLLRRLDTAAGPVLRTVGVVASTDPPGGAEAAPAEAAPAEAGSAEAGDAWGHVLDVPRYAQRLHAAGETRWGGGGDSWCSPTCVSMVLDFWGTGPTADRYAWVAPPGPRPQVVHAARHCYDHAFGGPGNWPFNTAYAATHGVDAFVTRLRSLAEAERFVAAGIPLIVSAAFTAGQVPGLDYDTRGHLMVLAGFTAEGDPVLNDPYAPDDERVRRTVPRGPFESAWQAGSGGIAYVLRPESTPLPPPPAQANW
>NC_014391.1|WP_013284807.1|1679316_1680609_+|PQQ-binding-like-beta-propeller-repeat-protein
MSPVIELGEMRHGESADDPADAPPRRPPGRTARVAVLGCLVLLVVTAAAGPSRRPEPIRVPAPQGAAFVVLADRVVVADGPGAIGRGGRVVAAYRLPGGEPAWRFALTDGDHVLGLTAVAGGLLVTSSPAGDGDSVSAMLDPATGTLRWRHPGYPVRTASGGLLLENPRPPGAGTVRAVDPASGEVRWTLPVPGQEVGYRRDDHGVTQLVLVTPQGRVTVYDADSGAVAHTGRVAPAADRAAYRYAQVVADLLLVEDARGTVTGYGLDRLDERWSLPVGSRAGLWFADCAGMVCLRDQVGGAQALDPATGRPAWSDERWLGMGPVGDRLIAAERGVGEELELSALDPPTGRVLARLGRWRVSGNDLPSGPLLGLRTLTEDRTLVGALDVAAGQVRIRGILPGAWSECADTGTELVCLRPTGGMAIWPVGR
>NC_014391.1|WP_013284806.1|1678057_1679320_+|PQQ-binding-like-beta-propeller-repeat-protein
MTVIDLGELRDDAPPGPAPRPPRAVGRPFRLLVVLLVALLTLTAATPPRGPVEWTLPGGLGSAVFVSGDVVYVVRPDRAGAVSGRELLAYRGDRERWRSPLPGVGTAVSVWEQDGRVIVAGRSVDNTDWQTVTYDAATGADVWRRPGIAFAVGRVLLMQSAASDTTTSIMEVDPADGRTVWTAPMTGALGFDVEPTGPVRMVLSPATGQTVVVDARTGARLVARDLDPVRRPGPRRLQLARGLLLEFRDGDGAIEAYDLDTLRPRWTVARKLVGHVESCGALLCAVGPTGGMTALDPATGAVRWSVDRWASVAAARGGRFLVGTPDTDTDADGGLAVLDQDDGRLIADLRGWTLVPQHESGGPLLATRPLGGGRRLLAEVGLSGDPPTIRGTLTGTDCTTGMTLLVCRRPGGDYMVRRLT
>NC_014391.1|WP_174361774.1|1676098_1677964_-|hypothetical-protein
MDPSLNPSSVEADAVVADPPRRARRRPARADVLAIGAYVLLGVLVCLNYWGDVEHRVSSHLPTDHSWFEWLFAHGAYSVQHLENPLFTTRQNAPDGVNMMANTSLLGVTLPLAPLTLLLGPQVMYALYLGAALSATAATSYWVLSRHLVRSRAAAFVGGAFLGFAPGIVHHANGQPNFVSNFLLPLIVARVLRLGEPGRWRRNGLALGLLVAYQIFINEEMLLLTALACLVVVVAYAVQRPRATRERAGSFVAALGLGGGLALLLTAYPIWFQFNGPQSYRGLQGGVFHNWGEDLVAFVTFARDTIAGDEAVEKTIGLTEQNTWFGWPLVLVALAALVLLVRRSVPARILAVLVVVFTIASIGPVVRFNGVETDIDGPWAYVPDDLPLVEMMMPTRLSLVVVAAVGVLLALAWDTLAGAGRPPVPAPRSGADDGGDDDGGTTARDTRRRVLRLAGFVAIAAAVVPLIPRPLPAERIDPPPHFITAGGWRPYVPEGRTLVPVPIPSNVHGLHTLRWSALTGQEFPVPGGYFIGPNERGEGVFGAPNRPTSTLIYSTMDANEVPEITEENRRQAVDDLRFWRASVVVLGAGPREAVLRDLMAELLGPPQRVDDVWIWDVRDRV
>NC_014391.1|WP_013284804.1|1674300_1676085_+|hypothetical-protein
MAVGRAETDQPVRLTEPAVPAPAPRRRRPRPADVLVVAGYLGLAVLLTTGQWRRPERLFHQAGDQMLFEWMLARAARAVTGGENPLWSGALNAPDGVNLMANTSVLGLGVPLTPVTVVFGSQAAFLVAVTLSLAGTATAWYALLARRLVRSRAAAAVGGLFCGFAPGMVAQAGAHLHMAAQFLVPVILALVFRPATDRVRRDGVLLGLAVAYQVFLGEEVLVFLALAAGVFAGAYALADRAAARRLAPVVARRLGVGALVAGVLLAYPLWFQFAGPGHYRGMPFHTEGYRLDVVSFVTTARQSVAGDARRAGLLSPNPTEQNSFLGPFLPLLAVLVVVRLWRRPLVRALAACGLLFALLSLGSPVVVNRHDTGLPGPYRLLAGVPLLDLVVPARFALVCVPVLGVLLALALDRVRRGGVRTWAPWAGAVAAALLPLAPTPIRAVPVPPVPAVVSGGGWREYVPPGRTLVPVPPVTGAAVSPAMFWSARTALAFDAPGGYFIGPRSATDPAARWGAPDRPTSLLLRRAAETGRVPPVGETERRQAVDDLRHWRAAALVQADSSPGDPVRATVDALVGPGRDVPGGYLWDVRPLVG
>NC_014391.1|WP_013284803.1|1671075_1672266_-|hypothetical-protein
MLSARRGATTGIALAALLLVTAGCGPVAERQPADLRVGYDSLDGTLAVWPPRGSLARDAAATAAITTAVRDWRSPVDDRVHVPTSGILFSGQVAGSALALVAADVPGESASWLLQLDRDGQRWRVVHATEYTDPGYLVYSDVLPVREPSGRRYLTSARVERLTGPDGKVLGTTDGVTDPVAVPDCRAVELTATLRATPSLPRGRAADRVLDLGTATEAPRYPLVRDETGAGKRALTGLDTCVLAGERGPFGSVPRRIGDREAPRSAPESWPMAKIATRSLGSVALGEGEPGELEQLSWETPAGTMTAVVYRPADGGTPVVSPADRSTTLQAYHLPMPGRPLAVLSWRTRDASFSAPPGTTRLVDRPGLVVVEHTDQRQTFSLAGTEKTWYRSLPTP
>NC_014391.1|WP_013284814.1|1688615_1690679_-|enoyl-CoA-hydratase/isomerase-family-protein
MSLAAPNEVVTKALLRQVAVPGLDRPAALITLDNGFDHTKPNTFGPAGLTSLDEAITAALSAEPAFIAVTGKPYIFCVGADITSLPALENREQALEIGRLGHRVFARLKDSGVPTFAFVNGAAMGGGLELALHCHYRTLSAGAAALALPEVSLGLIPGWGGTQLLPNLIGIPAATQVIIQNPLMQNKMLKPKQAAEMGIADVLLEPADFLERSLEWAAGVVRGEVTVTRPEVDKDMWAGVLYFARQTLDQRLHGAVPSAYKALDLLETAKDADFATGTAAEDEALADLVFSEELRSGLYAFDLVQRRAKRPAGAPDKGLARPVTKVGIVGAGLMASQLALLFARRLQVPVVMTDLDQSRVDKGVGYVHTQIEKAVSKGRMDKGTAAKLYGLVSGSVDKSVFADADFVIEAVFEDLGVKKQVWAELEKIVKPEAVLATNTSSLSITEMAAELEHPERVVGFHFFNPVAVLPLLEIVRGERTDDATLATAFAVGKQLRKSSVLVKDAPAFVVNRLLTRFLGTVFAAVDQGTPLDVANSALDPLGLPMRPLALLQLVGPAVAYHVGGTLHEAFPDRFGVSENLKRIADSGQPIVVDDQINDEVAKLLVVGDEPLTAEQVRQNALDALAQEIRLMLDEGVVAEAQDIDLCMILGAGWPFHLGGVTPYLDRTGTSERVTGKRFLPHGVASLR
>NC_014391.1|WP_013284815.1|1690675_1691872_-|thiolase-family-protein
MPREVRDVVFVDGVRTPFGKAGGMYANTRADDLVIRCIRELMRRNPQLPPEKVEEVAIAATTQIGDQGLTIGRTAALLAGLPKTVPGFAIDRMCAGAMTAVTTVASGIAVGAYDVAIAGGVEHMGRHPMGEGVDPNPRIVAEKLVDPSALVMGSTAENLHDRVPHITKERTDAFALASQQKTAKAYANGKLQGDLVPVAVRDPEAGWGLATVDEAPRDTSMEKLAGLKTPFRPHGKVTAGNAAGLNDGATAALLVAEDTARELGLPVGMRLVSFGFVGVEPEVMGVGPIPSTEKALRIAGLSIDDIGLFELNEAFAVQVLAFLDHFGIADDDPRVNPWGGAIAIGHPLASSGVRLMTQLARQFAEHPEVRYGLTAMCIGIGMGGTVIWENPHWEGGDK
>NC_014391.1|WP_013284816.1|1691975_1693295_-|ribonuclease-D
MTDEPPLRRRAAESRTGEASAQPTSALPEPADAGSETDTGAAVPLTAPRDGTPAPVATPAELDEVVARFAAGTGPVALDAERASGYRYSQRAYLVQLRRGGAGTALIDPLPLPDLSALDAVIAETEWVLHAASQDLACLAEVGLRPRRLFDTELAARLAGFERVGLAALTEQLLGFSLEKHHSAADWSSRPLPESWLTYAALDVELLVDLRDSLDEELQRQGKSGWAAEEFDALVRNGASPRVRAEPWRRTSGIHRVRGARAQARVRSLWYARDQIASRRDAAPGRVLPDSAIVAAAELDPKDEKTLLTLPGFGGRSVRRLARTWLAALDDARQLPDDALPVSPAVEGPPPPHRWAERDPVAAGRLARAREVVVGTAGAHRLPAENLIAPDSIRRLAWQPPAEITDETVAETLRGFGAREWQIGLLLPALTEALHTPQQ
>NC_014391.1|WP_013284817.1|1693527_1695087_+|trypsin-like-peptidase-domain-containing-protein
MTGGYGTGDDVPGHGGGDTAADRPGPLPPRFAPPAGSAPVPGSFPGGSEWAGTPGYPARAAVQPPAGYPGLPDPAGTPQPTPYAASSGVATPPATAQPGQPSYGTTPSEPGRSSYGTAPGQPSYGSAPAQPSYGSAPGQPSSFGAVPAQTSRSAAPAYPGQPAASPSYPGQPVSASPSYPGQPAASPSYPGGPGSSSYPDRAPAAPSYPGLSGSGPSYPGQPVSAPAYPGQPVSAPSQPGSAYPGQAAPVGGPAGFGAQPARRSRVAVVALALAAVLTVVTGVQAYQIYRLDDRLAAADKRMAEGQGTDASRLDGLEQRAGSLEKKAGAAFNPEAVASAVLPSVFRVRAGQFTGTAFAVGKAPSGGGTTLLTNFHVVESVFTAGERKVFLERKDQRFEATIIATDKDKDLAQLQTTAKFTGLVAARDPVRSGQQIIVVGAPLGLQDSVTTGVVSAFREDERGGGPVIQFDAPINPGNSGGPVINGSKEVVGIATAKARNAEGIGLAVPIKTACDRFRLC
>NC_014391.1|WP_013284818.1|1695174_1695990_+|hypothetical-protein
MSYPPAGGDNPPPAPGGTVYGNPYGSRPAPQQYDPNQPAPTLHQPTVSDGAPGYGGYQPATPGQPGYAPGAAPVPPPAQPMSAPPVSVPPVSAPGYAQPMSVPPASAPPVSGPGFGPPPMSGPPGPYGPVGAPPATGGGRKWAALVLGLVAALLFVFGGVMTFLYVSTNGELDKSRQTVSQRDGTISANQQEMEKLKGELKAVQERLSDTQQDLTGTKNDRDEQARQKKVIANCLDKLTTAMAAASRGDRAAFEAASKGLDKICDEAENYL
>NC_014391.1|WP_013284819.1|1696059_1696632_-|DUF3000-domain-containing-protein
MAPPIALPETFARAVAGLRSATPRPEIILEEVGAPQRLAPYAFALSAAVMRDDDEVATGRLILLHDPAGHEAWQGTLRLVTYVTAELEVDLASDPLLPGVGWTWLTDALDAQGAGHRAIGGTVTQTLSTRFGELAGPPAAGDIEIRASWTPLRADLGPHLLGWCTLLASTAGLPPPGVTALPTRRSAGAA
>NC_014391.1|WP_174361702.1|1696805_1697897_+|uroporphyrinogen-decarboxylase
MTTDTTGTAARDGEPRRGGPADSPFVRACRREPGPHTPVWFMRQAGRSLPEYREIRANVPMLESCRRPDLVTEITLQPVRRHGVDAAILFSDIVVPVAAAGIDLDIVPGTGPVVAEPVRTAADVERITPIGRDDVSFVDEAVRRLVVELGDTPLIGFAGAPFTLASYLVEGGPSRTHAKTKALMYGDPELWHALCARLAEVTLAFLQVQIDAGVSAVQLFDSWAGALSEADYRRFVLPHSTYVLGGLADAGVPRIHFGVGTGELLGAMGEAGADVVGVDWRTPLDVATGRIGPDKAVQGNLDPTVLLAGWPVVETEVRRIVEQGRAAPGHVFNLGHGVLPETDPEVLTRVVALVHELTARPER
>NC_014391.1|WP_013284821.1|1697906_1699316_+|protoporphyrinogen-oxidase
MVRPWRVAIVGGGITGLAAAVRLRDRAPEGTEITVYEQSGRLGGKLHTGELAGGPVEFGAESFLMRDPAGGESAAVTLARRLGLDASIVHPTVGQAALLVDGTLRQVPGGTLVGVPGDLDKVAAVAPPAADADRDAGHPLLAEGEDTSVGELVRKRLGDAVVERLVDPMLGGVYAGRADDLSLVTTMPALARAARAEHTLVGAVRAAQAAAPRAPGAPVFGTLAGGLSTLVEAAAAASGATIRRGAAVRELRRTPDGWRLTVGPTRDAEHVEADAVVLAVPARPAARLLAAAAPEAAGTVGALDYASVALITLALPGPALPELSGFLVPAGEGLTIKASTFFTTKWGHLRRPDGLALVRASVGRYGDETSLQLTDDDLADTVHRELSAVLGAPLPAPVARHVQRWGGALPQYTPGHTARVAAVRTALRAAHPTLAVAGAGYDGVGIPVCVRSGETAAEEIITALEGSAA
>NC_014391.1|WP_013284822.1|1699312_1700014_+|chlorite-dismutase-family-protein
MTEQTNAARLRELNETIRYTMWSVYRATSPLPSLRENVVDEVESLFTELAGKDVTIRGTYDVAGLRADADLMIWWHSSSSDALQDAYLRFRRTTLGRALTPVWSQMALHRPAEFNKSHIPAFLNDEEPRAYLCVYPFVRSYEWYLLPDAERRELLAEHGKMARGYPDVRANTVASFALGDYEWMLAFEADELHRIVDLMRDLRASGARRHVREEIPFYTGRRRSVAAIVNCLV
>NC_014391.1|WP_013284823.1|1700109_1701210_-|lytic-polysaccharide-monooxygenase
MSTPYRRPLPLAAAILGVCAVVAALLTTAFSGPASAHGSVVDPASRSYSCWQRWGGDFQNPAMATQDPMCWQAWQADPNAMWNWNGLFREGVAGNHQGAIPDGQLCSGGRTQSGRYNALDTVGAWKTVPVTNNFRVKFFDQASHGADYIRVYVTKQGYNALTSPLRWSDLELVGQIGNTPASQWTREVDGVSIQIPANAPGRTGRHVVYTIWQASHLDQSYYLCSDVDFGGSGPTTPPTSTPPTSTPPTSTPPTSPPPTTPNPAGGCTATYAITGSWGGGFQADVKVTNGSGSPIRGWSVSWNYQNGQQVNSAWNATVTTSGTLVTARNVAYNGSLAPGASTSFGFTGSAGATNPVPSIVSCTTTS

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Crispr_ID: NC_014391_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014391_3

2234358-2234447

Orphan

Consensus_repeat	Method
GGGGTTTGGCCGCCGTCCGGGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014391_3

>merge|NC_014391|3|2234358-2234447|CRISPRCasFinder
CCCCTTGGCCCGCCGGCCGGGGTTTGGCCGCCGTCCGGGGTTGGCCGCCGTCCGGGGGGGGGGGGGGGGGGGTTGGCCGCCGTCCGGGGT

>NC_014391|3|3|2234358-2234447|CRISPRCasFinder
CCCCTTGGCCCGCCGGCCGGGGT	TTGGCCGCCGTCCGGGGTTGGCCGCCGTCCGGGGGGGGGGGGGG
GGGGGTTGGCCGCCGTCCGGGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014391.1\|WP_145752723.1\|2247042_2247633_-\|sugar-transferase	unknown	unknown	gnl\|CDD\|376775
NC_014391.1\|WP_174361782.1\|2239820_2241005_-\|glycogen-synthase	unknown	unknown	gnl\|CDD\|273997
NC_014391.1\|WP_013285276.1\|2226679_2227336_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_014391.1\|WP_013285283.1\|2234491_2236594_-\|1,4-alpha-glucan-branching-protein-GlgB	unknown	unknown	gnl\|CDD\|235445
NC_014391.1\|WP_013285277.1\|2227346_2228735_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_014391.1\|WP_013285281.1\|2231353_2232958_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224720
NC_014391.1\|WP_013285273.1\|2223839_2225588_+\|CDP-glycerol-glycerophosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|367953
NC_014391.1\|WP_013285288.1\|2242375_2244019_+\|alpha-D-glucose-phosphate-specific-phosphoglucomutase	unknown	unknown	gnl\|CDD\|236050
NC_014391.1\|WP_030270475.1\|2228741_2229692_-\|TAXI-family-TRAP-transporter-solute-binding-subunit	unknown	unknown	gnl\|CDD\|270287
NC_014391.1\|WP_013285290.1\|2245076_2245943_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NC_014391.1\|WP_013285282.1\|2233040_2234117_+\|DUF2183-domain-containing-protein	unknown	unknown	gnl\|CDD\|227187
NC_014391.1\|WP_013285285.1\|2239001_2239730_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_014391.1\|WP_013285275.1\|2226256_2226595_-\|DUF952-domain-containing-protein	unknown	unknown	gnl\|CDD\|226033
NC_014391.1\|WP_013285291.1\|2245939_2246998_+\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	unknown	unknown	gnl\|CDD\|99740
NC_014391.1\|WP_030270460.1\|2244025_2244955_-\|NAD(+)/NADH-kinase	unknown	unknown	gnl\|CDD\|223139
NC_014391.1\|WP_013285274.1\|2225646_2226189_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|100048
NC_014391.1\|WP_013285287.1\|2241108_2242341_+\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234846
NC_014391.1\|WP_013285284.1\|2236581_2238702_-\|alpha-1,4-glucan--maltose-1-phosphate-maltosyltransferase	unknown	unknown	gnl\|CDD\|200482
NC_014391.1\|WP_030270473.1\|2230533_2231331_-\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NC_014391.1\|WP_013285279.1\|2229779_2230427_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014391.1\|WP_145752723.1\|2247042_2247633_-\|sugar-transferase	gnl\|CDD\|376775	pfam02397, Bac_transf, Bacterial sugar transferase. This Pfam family represents a conserved region from a number of different bacterial sugar transferases, involved in diverse biosynthesis pathways.	6.02473e-70
NC_014391.1\|WP_174361782.1\|2239820_2241005_-\|glycogen-synthase	gnl\|CDD\|273997	TIGR02149, glgA_Coryne, glycogen synthase, Corynebacterium family. This model describes Corynebacterium glutamicum GlgA and closely related proteins in several other species. This enzyme is required for glycogen biosynthesis and appears to replace the distantly related TIGR02095 family of ADP-glucose type glycogen synthase in Corynebacterium glutamicum, Mycobacterium tuberculosis, Bifidobacterium longum, and Streptomyces coelicolor. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_014391.1\|WP_013285276.1\|2226679_2227336_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.00431e-73
NC_014391.1\|WP_013285283.1\|2234491_2236594_-\|1,4-alpha-glucan-branching-protein-GlgB	gnl\|CDD\|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
NC_014391.1\|WP_013285277.1\|2227346_2228735_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.97718e-46
NC_014391.1\|WP_013285281.1\|2231353_2232958_-\|hypothetical-protein	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	0.00134057
NC_014391.1\|WP_013285273.1\|2223839_2225588_+\|CDP-glycerol-glycerophosphotransferase-family-protein	gnl\|CDD\|367953	pfam04464, Glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase. Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerization of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate units from CDP-glycerol to the linkage unit lipid.	2.48577e-07
NC_014391.1\|WP_013285288.1\|2242375_2244019_+\|alpha-D-glucose-phosphate-specific-phosphoglucomutase	gnl\|CDD\|236050	PRK07564, PRK07564, phosphoglucomutase; Validated.	0
NC_014391.1\|WP_030270475.1\|2228741_2229692_-\|TAXI-family-TRAP-transporter-solute-binding-subunit	gnl\|CDD\|270287	cd13569, PBP2_TAXI_TRAP_like_1, Substrate binding domain of putative TAXI proteins of the tripartite ATP-independent periplasmic transporters; the type 2 periplasmic binding protein fold. This subgroup includes uncharacterized periplasmic binding proteins that are related to Thermus thermophilus GluBP (TtGluBP) of TAXI-TRAP family. TRAP transporters are comprised of an SBP (substrate-binding protein) and two unequally sized integral membrane components. Although TtGluBP is predicted to be an L-glutamate and/or an L-glutamine-binding protein, the substrate spectrum of TAXI proteins remains to be defined. A sequence-homology search also shows that TtGluBP shares low sequence homology with putative immunogenic proteins of uncharacterized function.	9.9266e-107
NC_014391.1\|WP_013285290.1\|2245076_2245943_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	4.18284e-12
NC_014391.1\|WP_013285282.1\|2233040_2234117_+\|DUF2183-domain-containing-protein	gnl\|CDD\|227187	COG4850, COG4850, Uncharacterized conserved protein [Function unknown].	4.81325e-55
NC_014391.1\|WP_013285285.1\|2239001_2239730_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	6.49218e-19
NC_014391.1\|WP_013285275.1\|2226256_2226595_-\|DUF952-domain-containing-protein	gnl\|CDD\|226033	COG3502, COG3502, Uncharacterized protein conserved in bacteria [Function unknown].	3.80389e-39
NC_014391.1\|WP_013285291.1\|2245939_2246998_+\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	3.15117e-18
NC_014391.1\|WP_030270460.1\|2244025_2244955_-\|NAD(+)/NADH-kinase	gnl\|CDD\|223139	COG0061, nadF, NAD kinase [Coenzyme metabolism].	2.90517e-52
NC_014391.1\|WP_013285274.1\|2225646_2226189_-\|N-acetyltransferase	gnl\|CDD\|100048	cd03358, LbH_WxcM_N_like, WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization and transacetylation reactions of keto-hexoses. It contains an N-terminal LbH domain responsible for the transacetylation function and a C-terminal isomerase domain. The LbH domain contains imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), typical of enzymes with acyltransferase activity.	1.66215e-57
NC_014391.1\|WP_013285287.1\|2241108_2242341_+\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|234846	PRK00844, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NC_014391.1\|WP_013285284.1\|2236581_2238702_-\|alpha-1,4-glucan--maltose-1-phosphate-maltosyltransferase	gnl\|CDD\|200482	cd11344, AmyAc_GlgE_like, Alpha amylase catalytic domain found in GlgE-like proteins. GlgE is a (1,4)-a-D-glucan:phosphate a-D-maltosyltransferase, involved in a-glucan biosynthesis in bacteria. It is also an anti-tuberculosis drug target. GlgE isoform I from Streptomyces coelicolor has the same catalytic and very similar kinetic properties to GlgE from Mycobacterium tuberculosis. GlgE from Streptomyces coelicolor forms a homodimer with each subunit comprising five domains (A, B, C, N, and S) and 2 inserts. Domain A is a catalytic alpha-amylase-type domain that along with domain N, which has a beta-sandwich fold and forms the core of the dimer interface, binds cyclodextrins. Domain A, B, and the 2 inserts define a well conserved donor pocket that binds maltose. Cyclodextrins competitively inhibit the binding of maltooligosaccharides to the S. coelicolor enzyme, indicating that the hydrophobic patch overlaps with the acceptor binding site. This is not the case in M. tuberculosis GlgE because cyclodextrins do not inhibit this enzyme, despite acceptor length specificity being conserved. Domain C is hypothesized to help stabilize domain A and could be involved in substrate binding. Domain S is a helix bundle that is inserted within the N domain and it plays a role in the dimer interface and interacts directly with domain B. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_014391.1\|WP_030270473.1\|2230533_2231331_-\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	5.48403e-65

>NC_014391.1|WP_013285282.1|2233040_2234117_+|DUF2183-domain-containing-protein
MARPVRLWHCCRVPPTPPDQLAVPQLHRAARFEDAVHGLVERRLRRTGWQPNIIAYAGYGAPGWARVLCRVLLGRPDTRRRGRLDKVRGWRSFATLPAKHITVTIEADGVRQEVTADRSGFVDTVIEADFTPGWGCVRLSVADAEPVEALVRILDPAVRFGILSDIDDTVMVTALPRPLLAAWNTFVLDEHARTAVPGMAVLYERLATAHPGAPVFYLSTGAWNVAPTLTRFLSRHLYPAGPLLLTDWGPTADRWFRSGREHKRATLARLSREFPEVRWLLIGDDGQHDPEIYREFAAAHPDNVAGVAIRRLSPTQSVLAGSLPAPAGRSSSGPIGQKWLSAPDGAGLWKLLREADLV
>NC_014391.1|WP_013285281.1|2231353_2232958_-|hypothetical-protein
MSTTKRNPVRPRPDAPALVALLLGAAGVGYRLVLTLLTVPASNSDEATFGLAALHIAAGGERPVFLYGQRYMGVLESYLAAPLVGWAGPSWPVLRLPLLALFAIFLWLAYRLTRRLFSPWLAVAVVGLLALGSERVVRDQLTVVGGRPEVKPAVLAMLLIAVALGGRRIRHHWLATGAFGLLAGLALWSDWLIAPYLLVAAVVLAVAVPRDLIGWPGVLLVAGFLAGIAPVVKDNLVAPPGQDSLSVFHEISTKEGVAPSLAERLRGGLLEGVPLASGLCPMDGCARWAQWFGVLYPVLLVAAAALGLIAYRRAADHAARVRAVAILALVAGAVLTLLAYVRSPLAATDPLGNARYLSVLQISLPAVLWPLWLAAAHALRATTGWTARLGGTAAAVVLAGLTAATVAGTVAFLAGVPGVRDEERTARRLADTVRDAGLHEVYGDYWTCNRLIFNTGETVACGVLDGALTPGQNRYPAYWQRVARAERPGYVVAVGSPAERTLRRLLGDRADAAVVAEVGGSRVYHPDRAVRPWR
>NC_014391.1|WP_030270473.1|2230533_2231331_-|peroxide-stress-protein-YaaA
MLILLPPSEGKAEAGTGRRLDLSRLSLTELNPAREAVLTALVDLCAGPDETAARTALGLTEGQRGELRRNARLREAATAPAGRLYTGVLYEALGLDTLPPDAQRAARRQVLISSGLWGAVRFADRIPPYRCPIGARLPGLGALSAYWRAALGPVLEPAAGRGPVLDLRSGAYAATWTPRGALAERTVTVRVLHERIVDGTPARSVVSHFNKATKGRLVRDLLLADARPRTADALVGALRELKYTVEEAPRAAGRPRQVDLVVTEL
>NC_014391.1|WP_013285279.1|2229779_2230427_-|hypothetical-protein
MLTTLLDRPRPSPPPLDWLTLTDAFEVACMVRCTPPPAADVRRLDSGPHRGGIAEFNREDAAQRMRQLLGRLDVPVEHELTTGGLRRRYELHRLSVPPQHRAAYANLLTTGWRQGRRELLGGPFPGASAPRRLWRPRLAAAAWRAALLAGGRHVRRHCLGIRLADRDLAAVLVRGAALLDVPAALRPGSGCFLVVVPNGEHRERITESAELAPAS
>NC_014391.1|WP_030270475.1|2228741_2229692_-|TAXI-family-TRAP-transporter-solute-binding-subunit
MQPVSRHWPVRAAAPLALVLLLVAGLTGCRDEPSEPTRIRIATGSPTAVYHAFGQSLAALLNRELPGVRAEVVVTAASAQNVRLVGAGEAELGFTQADVLPPREPEHPSVLAVARVYDDLLHLVTRAGGPIRTLGDLRGRRVSVGADGSGTEITATRLLAVAQLGGDRVRQEHLGLDDSVAALREGRIDAFFFSGGLPVRGVADLAQRTSLRIVDLGDWTEPLRRAYGQVYVTRDVPRSVYRAAPVSTVANPNYLIVRADLPAALVREVTRLLMDRREELAAAHPAAGRMSPRSAIVTTPLPLHPGAAQWYRAAKP
>NC_014391.1|WP_013285277.1|2227346_2228735_+|HAMP-domain-containing-histidine-kinase
MRRRLVISYLLLMVLVLIALETPLAATLATRETDRVRADRLADATRFASLAGPALRGGSPGPLDGELAAYDALYGIGAAVVDRDRRTVVASSGWEPGAGTRAALDTALSGQQFSGPESVWPWVGGPVVTAVPINDGGEVLGAVVTTSPADGVRRTVTVWWLLLAGIGLLAVLACVSTAFGLAGWVLRPVTELDAVTHEIAEGRRAARVRAGLGPPELRRLATSFNDMADAVSDVMDRQRAFVAHASHQLRNPLTALRLRVEELGPSLTDADGRAEHRLALEETDRLATVLDALLTLARAEREENERVTVDATATAASRVAAWLPLARHREVTLRLDAEDAPAYARTVPTAIDQALDALIDNAVKFSGTGGEVTVTVRAADDGTVLTVGDTGPGMTTSQLDQATERFWRAPDAQNVDGVGLGLTIAAVLVDASDGRLTMRQGEPRGLVAELWFPAPADAPVRC
>NC_014391.1|WP_013285276.1|2226679_2227336_+|response-regulator-transcription-factor
MRILLVEDDRRVAAALSSALTRRGYQVEHAATVAAALSAAPCDLVLLDLGLPDGDGTDLCRELRRRSSRLGIIAVTARGEERDRVLGLRLGADDYVVKPFSMVELQARIEAVLRRAAHTAPQRNLIEAGTVRIDVGGRTVTVAGRDVSLTRKEFDILLSLARQPGVAVPRERILLDVWGTTWADRHTVEVHVGSLRGKLGDPTLVETVRGVGYRLREA
>NC_014391.1|WP_013285275.1|2226256_2226595_-|DUF952-domain-containing-protein
MIYKILTDDEWTRARADGRFAGTAMDRQDGYVHLSAADQVVETARRYFAGVTGLTVLAVDESRLGDALRWEESRGGALFPHLYGALPVDAVVAAHPLPADRPAADAVAELLG
>NC_014391.1|WP_013285274.1|2225646_2226189_-|N-acetyltransferase
MTDSNDRSASVFVHPTADVESGAQVGDGTKVWHLAHIRSSAQVGAGCVIGRNVYVDAGVTVGDLVKIQNNVSVYQGVTIEDEVFVGPCAVFTNDFRPRAQNPDWTITPTLVRRGASIGANATLVCGIEVGEYAMIAAGSVVTRDVKPYQLVAGNPARPKGWVDAKGEVISRDVDNPPHQG
>NC_014391.1|WP_013285273.1|2223839_2225588_+|CDP-glycerol-glycerophosphotransferase-family-protein
MFSRVRSQQGLAAVGATLLGYAVMVLAGVLGLVVPYAVAAVVAVAGELALAGRHTETATLLDKAGLGETFRRLVRDLSVVLLVVAAVRPGVAGTVAVLLLPAALWTVAVATNAVTKVIDGRVDPPAYTRNIDLGALRRVPVPPAWARLLAGLRMPLLNVLLVPAAVVAAALDRVAPVVLTALVTLAAGLVTAAVLALTALRGRGKAPGVLPAVHDWMARERPEVALYFAGPAKDVYQANMWLAPVEATGRRAVVLLRAADAFEQLADTRLPVICVPAGVDFMNLDLGSLRVALYAANVGANIHLLREPGVKHVFVGHGDSDKQASVNPYSKVYDEVWVAGPAGRERYARADVGVLDRDIVEVGRPQLAGVHTFGSGAADHRFTVLYAPTWEGWLDDDPYHTSLVLMGERIVSGLLAAGDVRVIYKPHPLTGTRSPKARAVHERIVSRIKAAGGETDPSSLDGTAHLVVTGRTPGLFDCFNVTDLLVSDVSSVVSDFVQSERPYVVANPAGLPEDEFRRQFPTARAAYLLSADCGELTKILDVTRAGDDPMTGARRELKEYLLGPAGSNPMDRFRDEIGRLCG
>NC_014391.1|WP_013285283.1|2234491_2236594_-|1,4-alpha-glucan-branching-protein-GlgB
MDQLIAGEVHDPHAVLGAHPADGSTTIRTLRRGAGEVAVLADGERHPMKRVHDAGVFEAVLPGEVLDYRVEVDGTTHDDPYRYPPTLGDLDLHLIGEGRHERLWAALGARVFDEGVAFTVWAPNARAVRLIGDVTGWAPDDGWPMRSLGSSGVWEIFVPGMPVGSRYKYRVLGADGRWRDKADPMAARTEVPPATASVVHESRYEWGDADWLARRSRQAPHQEPMSVYEVHLGSWRPGLGYRELAEQLTAYVLEMGFTHVEFLPVMEHPFGGSWGYQVTGYYAPTARFGDPDDFRHLVDRLHAAGIGVLLDWVPAHFPKDEWALARFDGTPLYEHPDPRRGEHPDWGTYVFDFGRNEVRNFLVANALYWLDEFHIDGLRVDAVASMLYLDYSRQDGQWAPNVHGGRENLEAIAFLQEVNATVYRHHPGVLMIAEESTAWPGVTRPTSEGGLGFGFKWNMGWMHDTLLYTSKDPVYRQHHHHQLTFSLAYAWSENYVLPISHDEVVHGKGSLAGKMPGDTWQRLATVRALLAYMWAHPGKQLLFMGCELADDREWSEERGLDWYLTHDPARAGVQRLVADLNRVYRESPALWAQDTDPAGFRWIAGDDVANNAVSFIRIAPDGQTLVCVANFSALPLEDYRIGLPAGGTWTEALNTDAHHYGGSGVGNLGEVHAENVPWHGLPASVSLRVPPLGVLWLRPA
>NC_014391.1|WP_013285284.1|2236581_2238702_-|alpha-1,4-glucan--maltose-1-phosphate-maltosyltransferase
MTGRFPIEDVSPVVSCGRYPAKAVVGEVVPVSARAYREGHDALGCNVVWLGPDGAARPFTRMRPGEPGQDRWHATIRPDAVGLWRFAVEAFGDPYLTWQNAVTKKLAAGQGAAELANDLAEGVRVLTAALDLVPRADRDRVREAVRALADDDLDLPRRVSAALDLADLLWEHPVRELVTTGEERTLWVDRPRAIFSAWYEFFPRSEGAVPATVDAPARSGTFATAMERLPGVAAMGFDVLYLPPIHPIGRVNRKGRNNALTAGPDDVGSPWAIGAAEGGHDAIHPDLGTPEDFRDFVAAAAEQGLEVAMDLALQCAPDHPWVTEHPEWFTTRADGSIAYAENPPKKYQDIYPLNFDNDPEGIRAEVLRVVLHWVGEGIRIFRVDNPHTKPFDFWHWLIAEVKKVDPDVLFLAEAFTRPAIMHGLGKIGFTQSYTYFTWRTTAAEMREYCEELVASVDWMRPNFWPNTPDILHSSLQHGGPPMFKIRAVLAALLSPSWGMYAGFELFEHVARPGAEEYLDNEKYELRPRDWDAALAQGRSLAPFVTTLNRVRRDNPALHRLRNLRFHDIDNPALLCWSKHDPETGNTVIVVCSFDSREVQWGNTTLDMPALGLDWHERFTVRDELTGAEYDWGQRNAVRLDPYLQPAHVLTVRRPAAPEPPQPAAPTAAEPEQPTAPDLTVEDVPADLSGGTAPTAPADKDDARWTS
>NC_014391.1|WP_013285285.1|2239001_2239730_-|class-I-SAM-dependent-methyltransferase
MPDAIFAHPRLAPVYDAFDGDRDDLDAYLAIADELDARVVLDLGCGTGNLALLLAPHGRTVVGVDPAGASLAVARSKDREGRVRWVHGDATTLPPLRADLAVMTGNVAQVFRTDDDWARTLRGVHGALRPGGHLVFETRRPERRAWEEWAADTAPVTRDVPGVGPVERRLEVTAVDLPFVTFRFTYRFPADGAVVTSDSTLRFRDRDEVEASLAAAGYRVLDVRDAPDRPGREFVFVAQRST
>NC_014391.1|WP_174361782.1|2239820_2241005_-|glycogen-synthase
MRVDLLTREYPPEVYGGAGVHVEYLARELRRLADVRVHCFGAPRDEQGVTAYAEPAALAGANAALRVMGVDLEMAAGTAGTDVVHSHTWYANLAGHTAKLLHGVPHVVTAHSLEPLRPWKAEQLGGGYALSSWCERTAFEAADAIIAVSAGMRRDVLTAYPAVNPDRVRVVYNGIDTAQYAPDPGTDVLDRLGIDPVRPSVVYVGRITRQKGLPYLLRAARELPADTQLVLLAGAPDTPEIAAEVEGLVAELRATRSGVIWVAAMLPKHEVIQVLTHATVFACPSVYEPMGIVNLEAMACETAVVATATGGIPEVVADGETGLLVPIEQAGDGSGTPLDPERFVADLAARMNELLGDPERIAAFGAAGRRRAVEHFSWDAIARQTIEVYRSVGV
>NC_014391.1|WP_013285287.1|2241108_2242341_+|glucose-1-phosphate-adenylyltransferase
MAAKVLAIVLAGGEGKRLMPLTTDRAKPAVPFGGMYRMVDFVLSNLANAGFLKIVVLTQYKSHSLDRHITKTWRMSTLLGNYVTPVPAQQRRGPWWFAGSADAIYQSFNLINDEQPDYVIVFGADHIYRMDPRQMVDDHIASGAGVTVAGIRQPLSTADQFGVIEVGEDGKRIRAFREKPTDAVGLPDAPDEIYASMGNYVFTTKALCEAVERDAADKTSKHDMGGSIIPMLVERGEANVYDFKDNEVPGSTDRDRGYWRDVGTLDSFYDAHMDLINVHPVFNLYNFDWPIYTEQPPYPPAKFVHAWGERVGRAVSSMVSPGSVISGSLVENSIVAPKVKVHSWAHVDGAVLMEGVQIGRHAVVRRAILDKNVHVPEGAEIGVDLEKDRQRYTVSDNGIVVIGKGQRVEP
>NC_014391.1|WP_013285288.1|2242375_2244019_+|alpha-D-glucose-phosphate-specific-phosphoglucomutase
MAHPRAGQPAQPDDLVDVPRLVTAYYAEHPDPDDPAQQVSFGTSGHRGSSLRNAFNSDHILAVTQALCDYRREQGLSGPLFLGRDTHALSAPAEADALEVLAANDVTVLRDSRDGYTPTPAVSHAILTHNRGRTSGLADGIVITPSHNPPSDGGFKYNPTHGGPADTDATKWIQDRANAILAAGLKEVKRIPYARARAAATTGEYDFLARYVDDLPAALDIDAIRDAGVRIGADPMGGASVAYWGEIAERHRLDLTVINPLVDPTWRFMTLDGDGKIRMDCSSPNAMASLIAARDDYAVSTGNDADADRHGIVTPDGGLMNPNHYLAVAIGHLFRTREQWGPGAAVGKTLVSSSMIDRVAADLGRPLLEVPVGFKWFVPGLLDGTVGFGGEESAGASFLRRDGGTWTTDKDGILLCLLAAEIIATTGRTPSEHWAELADRFGAPAYARIDAPADRAQKAVLAKLSPEQVTATELAGEPITAILTTAPGNGAAIGGLKVTTGSGWFAARPSGTEDVYKIYAESFQGPEHLARIQEEAKALVDGVLATA
>NC_014391.1|WP_030270460.1|2244025_2244955_-|NAD(+)/NADH-kinase
MAGDVLGLVLHPTRDVSEVVGIVADWAARHRITLAVRAEDRARVPAAVEAIAADELADRCAALISIGGDGTMLGALRMAVRDPKPVLGVHLGRVGFLVEVEPPDLPRALERLVEHDFTVESHACLACDVCGDDVVAFNDIALVRQPGAGFVTATLAVDGQRYGYYRCDALVVSTPTGSTAYSYAAGGPLISPATEAMVVTPSAPMAGISRSVLLSAHETVHLELRADSAPVAVEMDGLLIRQAATEGSVHIRYVKDAGRVVRLDPRRYQERNQLKLSLLDLPLLPDQLRELLPDGLREQLSRRELPPPR
>NC_014391.1|WP_013285290.1|2245076_2245943_+|GNAT-family-N-acetyltransferase
MPVPYGVQSIVPAADVGVPSRADAPGLRVRPAIVADAEWLAEVSQASFARHLHDYLTSAQPGVGRFWEVVLAHPESFPGRCFLVADDQDGRRLGFADLTRVEPGLAHLSYICVVEAARGRGVARELLRAYARAHPDLRSMRLDVFADNAPARALYDRLGFASDSTTTWWVADLALGGVAPAADVRFDGLHAARAWLDTYGFGELTVVAGDATHVLGRPSPGVLRCFDPATLRRPAVVAAVVRAFPGIDRVLVMTPGEDAPPSAVGPLRAVNRSLRMSTTEIRARLELP
>NC_014391.1|WP_013285291.1|2245939_2246998_+|DegT/DnrJ/EryC1/StrS-family-aminotransferase
MTQTIPKTATDPGAFRTPSLFYRAAREGMRDLLAQPEVWRGDRRDILLPSFIGWSANEGSGVFDPVTELGLDPGFYDLTEDLAVDVSSLEARLAERPYDVVVVIHYFGRTERAIGRIRELTDRHGALLLEDLAHAWFTHALGGPAGRTGEVSLYSLHKMLPMPGARGGMITYRDPGRLTGQRETEPDLSRHVLDHDTLGIAARRQENFRALTALLRDLPELGVAFELMWPELAPDDAPQTLPVRILGTGRENRDHVYAEMNREGFGMVSLYHTLIAQLRDHPSMARLSRQIINFPVHQDVAPADYPALVASFQRALGTLPERGALAPAGRPAAPAQSGASAPRPSGVPTGSA
>NC_014391.1|WP_145752723.1|2247042_2247633_-|sugar-transferase
MTVALVVLVVTAPVVAVAALLVLAQFGSPVFFRQERTGRYERRIRVLKLRTMSDDRDAEGRLLPDGVRCRGVGRTLRRLSIDELPQMVNVLRGDLSLVGPRPLLLRYDPWYTDRERKRFEVRPGITGLAQVNGRNDLAWTERLELDVRYVLDWSLWLDLRILARTAGKVLRASGVAVDPSAQMLDLDQERRLTGVR

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Crispr_ID: NC_014391_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014391_4

2469976-2470072

Orphan

Consensus_repeat	Method
GTGGAACGCCGTGGGTGTCTCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014391_4

>merge|NC_014391|4|2469976-2470072|CRISPRCasFinder
GTGGAACGCCGTGGGTGTCTCGCGGGCGTTGTGACACCCGTGGCGTTCCAGTCGGCGGGGATGCCGCGGATGAGTGGAACGCCGTGGGTGTCTCCCG

>NC_014391|4|4|2469976-2470072|CRISPRCasFinder
GTGGAACGCCGTGGGTGTCTCGCG	GGCGTTGTGACACCCGTGGCGTTCCAGTCGGCGGGGATGCCGCGGATGA
GTGGAACGCCGTGGGTGTCTCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014391.1\|WP_013285502.1\|2472661_2473102_+\|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|235443
NC_014391.1\|WP_013285503.1\|2473188_2473746_+\|elongation-factor-P	unknown	unknown	gnl\|CDD\|234788
NC_014391.1\|WP_013285508.1\|2476580_2477897_+\|dihydroorotase	unknown	unknown	gnl\|CDD\|236479
NC_014391.1\|WP_013285492.1\|2462762_2465444_+\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NC_014391.1\|WP_013285494.1\|2465628_2466090_+\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|335420
NC_014391.1\|WP_013285497.1\|2468256_2469435_+\|chorismate-synthase	unknown	unknown	gnl\|CDD\|235438
NC_014391.1\|WP_013285507.1\|2475657_2476584_+\|aspartate-carbamoyltransferase-catalytic-subunit	unknown	unknown	gnl\|CDD\|234849
NC_014391.1\|WP_174361785.1\|2473769_2474180_+\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|273891
NC_014391.1\|WP_013285487.1\|2458258_2459674_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NC_014391.1\|WP_013285490.1\|2461966_2462428_+\|DUF948-domain-containing-protein	unknown	unknown	gnl\|CDD\|377605
NC_014391.1\|WP_013285506.1\|2475017_2475599_+\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	unknown	unknown	gnl\|CDD\|235365
NC_014391.1\|WP_013285491.1\|2462460_2462766_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013285505.1\|2474242_2474731_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|319351
NC_014391.1\|WP_013285489.1\|2461202_2461820_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013285501.1\|2471588_2472665_+\|3-dehydroquinate-synthase	unknown	unknown	gnl\|CDD\|234565
NC_014391.1\|WP_013285496.1\|2467285_2468098_+\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|234703
NC_014391.1\|WP_013285499.1\|2470156_2470957_-\|cytochrome-c-oxidase-assembly-protein	unknown	unknown	gnl\|CDD\|378238
NC_014391.1\|WP_013285498.1\|2469431_2469941_+\|shikimate-kinase	unknown	unknown	gnl\|CDD\|234654
NC_014391.1\|WP_013285500.1\|2470953_2471496_-\|DUF2243-domain-containing-protein	unknown	unknown	gnl\|CDD\|370775
NC_014391.1\|WP_013285495.1\|2466086_2467286_+\|endolytic-transglycosylase-MltG	unknown	unknown	gnl\|CDD\|376862

Protein	Function_ID	Function_description	E-value
NC_014391.1\|WP_013285502.1\|2472661_2473102_+\|type-II-3-dehydroquinate-dehydratase	gnl\|CDD\|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	1.30963e-82
NC_014391.1\|WP_013285503.1\|2473188_2473746_+\|elongation-factor-P	gnl\|CDD\|234788	PRK00529, PRK00529, elongation factor P; Validated.	2.29216e-111
NC_014391.1\|WP_013285508.1\|2476580_2477897_+\|dihydroorotase	gnl\|CDD\|236479	PRK09357, pyrC, dihydroorotase; Validated.	0
NC_014391.1\|WP_013285492.1\|2462762_2465444_+\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NC_014391.1\|WP_013285494.1\|2465628_2466090_+\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|335420	pfam03652, RuvX, Holliday junction resolvase. This family of nucleases resolves the Holliday junction intermediates in genetic recombination.	1.18756e-48
NC_014391.1\|WP_013285497.1\|2468256_2469435_+\|chorismate-synthase	gnl\|CDD\|235438	PRK05382, PRK05382, chorismate synthase; Validated.	0
NC_014391.1\|WP_174361785.1\|2473769_2474180_+\|transcription-antitermination-factor-NusB	gnl\|CDD\|273891	TIGR01951, nusB, transcription antitermination factor NusB. A transcription antitermination complex active in many bacteria was designated N-utilization substance (Nus) in E. coli because of its interaction with phage lambda protein N. This model represents NusB. Other components are NusA and NusG. NusE is, in fact, ribosomal protein S10. [Transcription, Transcription factors].	4.11411e-47
NC_014391.1\|WP_013285487.1\|2458258_2459674_+\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	1.05557e-15
NC_014391.1\|WP_013285490.1\|2461966_2462428_+\|DUF948-domain-containing-protein	gnl\|CDD\|377605	pfam06103, DUF948, Bacterial protein of unknown function (DUF948). This family consists of bacterial sequences several of which are thought to be general stress proteins.	5.20145e-16
NC_014391.1\|WP_013285506.1\|2475017_2475599_+\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	gnl\|CDD\|235365	PRK05205, PRK05205, bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR.	1.59837e-93
NC_014391.1\|WP_013285507.1\|2475657_2476584_+\|aspartate-carbamoyltransferase-catalytic-subunit	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	0
NC_014391.1\|WP_013285505.1\|2474242_2474731_-\|transcriptional-regulator	gnl\|CDD\|319351	cd16837, BldD_C_like, C-terminal domain of BldD and similar transcription factors. The Streptomyces transcription factor BldD dimerizes via an unusual mechanism that inolves a tetrameric c-di-GMP assembly. BdlD is involved in controlling multicellular differentiation in sporulating actinomycetes.	5.92871e-29
NC_014391.1\|WP_013285501.1\|2471588_2472665_+\|3-dehydroquinate-synthase	gnl\|CDD\|234565	PRK00002, aroB, 3-dehydroquinate synthase; Reviewed.	1.76111e-169
NC_014391.1\|WP_013285496.1\|2467285_2468098_+\|shikimate-dehydrogenase	gnl\|CDD\|234703	PRK00258, aroE, shikimate 5-dehydrogenase; Reviewed.	4.49497e-89
NC_014391.1\|WP_013285499.1\|2470156_2470957_-\|cytochrome-c-oxidase-assembly-protein	gnl\|CDD\|378238	pfam09678, Caa3_CtaG, Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG). Members of this family are the CtaG protein required for assembly of active cytochrome c oxidase of the caa3 type, as found in Bacillus subtilis.	2.26072e-54
NC_014391.1\|WP_013285498.1\|2469431_2469941_+\|shikimate-kinase	gnl\|CDD\|234654	PRK00131, aroK, shikimate kinase; Reviewed.	7.01136e-74
NC_014391.1\|WP_013285500.1\|2470953_2471496_-\|DUF2243-domain-containing-protein	gnl\|CDD\|370775	pfam10002, DUF2243, Predicted membrane protein (DUF2243). This domain, found in various hypothetical bacterial proteins, has no known function.	3.58544e-60
NC_014391.1\|WP_013285495.1\|2466086_2467286_+\|endolytic-transglycosylase-MltG	gnl\|CDD\|376862	pfam02618, YceG, YceG-like family. This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of YceG was solved by X-ray crystallography.	3.01499e-80

>NC_014391.1|WP_013285498.1|2469431_2469941_+|shikimate-kinase
MSTRPVCVLVGAPGSGKTTVGTALAEALGVDFRDTDADIENLAGKPIPEIFVDEGEEHFRTLERAAVAAALASHAGVLAVGGGAVLAEENRAALIGHTVVHLSVELPDAVKRVGLGAGRPLLALNPRATLKHLMDQRRPLYAEVATATVVTDGRTPQELAAEIAALLKP
>NC_014391.1|WP_013285497.1|2468256_2469435_+|chorismate-synthase
MLRWLTAGESHGPALVAMLEGVPAGIEVTTGEISGELARRRLGYGRGARMSFEQDEVEIIGGLRHGVTLGSPVAIRVGNSEWPKWRTVMAADPVDPEELASQARNAPLTRPRPGHADLAGMQKYGHTDARPILERASARETAARVAVGTVAKALVRQALGVEIVSHVVELGPVAVKPGLRPTPEDAARIDADPLRCLDAEASARMVAEVDAAKKAADTLGGVVEVLAYGVPPGLGSHVQWDRKLDARLATALMSIQAIKGVEIGDGWQQARSRGSEAHDEIVPTATGVRRITDRAGGLEGGITTGEPLRVKAAMKPISSLNRALATIDVTTGEPATAINQRSDVCAVPAAAVVAEAMVALVLAEAAVEKFGGDSIAEMRRNLNGYLDSLVIK
>NC_014391.1|WP_013285496.1|2467285_2468098_+|shikimate-dehydrogenase
MADPRRAAVVGRPIAHSLSPVIHTAGYAAAGLTGWSYTRIEAGADELPGLVAGLGPEWAGLSVTMPGKEVALALADEVSPAAAAVGAANTLVRRQDGTWYADNTDVTGMVEVLTGAGCVAGAVVTVLGAGGTARAAIAAAARIGAAEVTVVARRPEAVDELRPVAAAAGVPLAGAEWDGAPSHARADLVISTVPKGVADPLADNFDWRPESVFFDVVYDPWPTPLAAAALAAGCRVVSGLDLLLAQAFGQFEHFTGVTAPRTAMRAALPV
>NC_014391.1|WP_013285495.1|2466086_2467286_+|endolytic-transglycosylase-MltG
MIDDLDLGFDEPDRGEKGRHRRGAVRRRQGKSGGGRGKTLLALALALVLLGGIGGGAFYGFDRVQNYFVTPDYDGSGTGEVTVEIKQGALIADMADALVAADVVKSTKAFIEAAEENSRSKNIQPGTYKMRKQMSGDAAVVALLDLKNKIVNGITIPEGLTAKTVYKRLSEKTDIPVKDFEAAAKDPEALGVPDWWFKRSDGKKVNPSIEGFLFPDTYEIPPKATAETVLKLMVDNFLTVTSGMQYAEKVQKDRGGITPYEALIVASLAQAEAGNKADLGKVARVAYNRVYGEFPCNCLEMDVTVNYYLELTGQKTKASKDMTAAELDNPKNPYNRKLRGLVPSPINNPGKEALEGALSPPDGKWLYFVAISRDGRSAFAETYAEQKRNEQKAREAGII
>NC_014391.1|WP_013285494.1|2465628_2466090_+|Holliday-junction-resolvase-RuvX
MSEVSRGVRLGVDVGQVRVGVARCDPHGILATPLVTLARDLTAEPDAVPADMAELVRLAAEHEAVGIVVGLPVNLAGKHGPAALNVSAYASRLADVMRPIPVTLTDERMSTVVASRRLAERGVRGKRQRAVVDQAAAVEILQSWLDAQRRRTQ
>NC_014391.1|WP_013285492.1|2462762_2465444_+|alanine--tRNA-ligase
MKTAEIKRRFLAHFEANGHTVVPSAPLPAISDPNLLFINAGMVQFVPYFLGQQTPPYARATSVQKCIRTPDIDEVGKTSRHGTFFQMNGNFSFGDYFKSGAIPLAWDLATKPVEAGGFGLDPERIWATVYLDDDEAYDIWRATGVPAERIVRRGKADNFWSMGIPGPCGPCSELYYDRGPAYGREGGPEVDEDRYLEFWNLVFMQFERGPGVGKEDFPILGDLPAKNIDTGMGLERMASLLQGVDNLYEIDEVKPILDRAAELTGKRYGVHSGHAANESHPDDVRLRVIADHVRTSLMLIGDGVTPSNEGRGYVLRRIMRRAIRAVRLLGYQDRALPELLPVARDCMAPSYPELAEDFGRISQYAYAEEDAFLATLRAGTTILDTAIAETKSAGKAALSGDKAFQLHDTYGFPIDLTLEIAAEQGLQVDAEGFRRLMADQRSRAKADAQARKTGHTDVSAYRSVLDGGGPVEFTGYTELSRESRVRALLSGGAAVSAAVEGDTIELVLDTTPFYAEGGGQQPDQGLITVGGGQVEVFDVQQPVPGLIVHRAKVVRGEVRSGETGYAEIDVSRRRAISRSHTATHLVHQTMRNFLGESATQAGSLNAPGRLRFDFNTPTGVAPSVLHDVEQQVNEVLLADLEVHAFVTSQEEARRIGAMALFGEKYGERVRVVEVGDYARELCGGTHVARSAQLGLVKILSEASVGSGVRRIEALVGMDAFGFLAREHLLVSRLAELFRVPGEQVADRVEQTVTQLRDAEKELEKLRAQLVLGGAGALAAQAKDVRGVAYVGTEAPEGAAANDVRTLAQEIRGRIDAARPAVIAVAARANGKASLVVAVNQAARGRNLSAKDLVKAAFSGRGGGSDDLAQGGGLPATEAPNLLVTVERAVADAA
>NC_014391.1|WP_013285491.1|2462460_2462766_+|hypothetical-protein
MRRLFWLGIGLAVGVLVVRKATRTAQAYTPAGIASGLSESAGGLVESLRAFVDDVRVGMAEREQEIHEAFARGEVYDDQFAELREDPRIGDREIFPEDHQR
>NC_014391.1|WP_013285490.1|2461966_2462428_+|DUF948-domain-containing-protein
MSGGEIAALIAAGAFLMLVLVLAVPILRLRHTVDATTRMITDVNERTAPLLGDVNTTVKNVNVALEQVQTSLDGVNLQLAKVDTMTSHAQNVTANVANLATVVSAAAANPLVKVAAFGYGVRRAASARRHAETEREVRDTIKQQRRAAKRGNR
>NC_014391.1|WP_013285489.1|2461202_2461820_+|hypothetical-protein
MRERSRLRLGILALVSLVLLGAVPLYFGMRTLSRDPVFDTLDALAVPAWAQSNTVDNVSGSRWCLQDCRLRERSVESEQGWKETVAVYEEALAGDGWRRWKVDRCPDEKVPGSYTCWRRDELTLDLWVRDRTCTPPPVDGAPAPTAPPAPAAAECTGSLVSVKVRNAIDDERTGPTPTTDPSLTGEDPYPTLTDDPLGEATPSPS
>NC_014391.1|WP_013285487.1|2458258_2459674_+|hypothetical-protein
MARGPERPADGPDERRDPRGKGRRWGRGRAEPELDPTVVGEELGWIDDLRTAKQQGGELGPDGGVPAPRPDADPSWPDGEPSRPPRPAAAPGPGPGMPPGGRQAPRPPAPGSPPPSTGQPVPPPSPAGRPGTPPAGAPQTPGRAVPPPAAAPQTPGRAVPPPAAPHTPGRPHPGGPAPVGRTDPTLPPVTGRPGPAAPPAAGRPGGPVTGRPGTDLPPAPGRPGMDTPPPPGRSGVDTAPPSGRPGVDMPPAPGRPAADTPPGARPPVVDAPSGGGRPGPEAPPGGGRPGPRPPVMRRPDTPGPAAPPVRPGGPETGAPRRPGDGPWPGGPEAGAPRRPVDGPWPGVPEAPRPADAPYRRRVDGPTGQQPPVAGTRVPPAAPPPGRAPAAPGRPPADGDSRVPPTPRGRHGAGPEVPHQADPTIPPPSGGRRARPDDTAGIQPVSGGARRARAEDADAVQPVPGGTPSAPR
>NC_014391.1|WP_013285499.1|2470156_2470957_-|cytochrome-c-oxidase-assembly-protein
MTVAHAGHADGGFPVTALIPVAMSWAYLAAALRLRDPGGPGWPHARTASFGLGALLLVAGLLWPAGDFVGHMWQHLLIGMLAPLALVLGAPVTLLLRTLDRRTGRALVHLLRHPVARVLGHPVTGLLLTAGGLWLLYLTPLYRATLDSPALHTLVNLHFLLSGCLFAWSIAGPDPGPHRPRVPVRLVVIGVGVAAHATIAQLLYAGLFVDVPATAAELRAGATLMYYLGDLAEIALALALLATWRPEPARRRRAGRRTARAAAANA
>NC_014391.1|WP_013285500.1|2470953_2471496_-|DUF2243-domain-containing-protein
MSETRAHATRPESATSIRLPATILGVGLGGFVDGIVLHQVLQWHHMLSSTGSDRIGVREYPVDTVPGLQMNTLWDGLFHVVTWVAVLTGLALLYSRVTHSRGRLWRSPMLWGWALIGWGLFNLVEGIVDHHLLGIHHVRGGPNQLWWDLGFLALGVVLIAAGWAIQRRARAVDLCPPERR
>NC_014391.1|WP_013285501.1|2471588_2472665_+|3-dehydroquinate-synthase
MDEVTRIPVGGERPYDVLVGRDLLNPPPRLLPGAERVAFLHAPPLKALADRLADGVREGGVTPLLIEVPDAEAGKHVDVAAACWDRLGDAGFTRTDAVVGVGGGAVTDLAGFVAATWLRGVRWVPVATSLLGMVDAAVGGKTGINTAAGKNLVGAFHPPAGVLADLATLDSLPPADLAAGMAEVVKCGFIADPVILDLVEDDPAAALDPAGPVLRELVERAVRVKAGVVAGDLRESGVREVLNYGHTLAHAIEKVEGYRWRHGHAVAVGLVYAATLARLAGRLDAADAERHRRVLAALDLPTGYRADAWPELLAAMRVDKKARGSRLRFVVLDGLARPAIMEALPDDLLAAAYAEISS
>NC_014391.1|WP_013285502.1|2472661_2473102_+|type-II-3-dehydroquinate-dehydratase
MRVYVLNGPNLGRLGTRQVDVYGVTSYAQLVADCERHGRELGLDVVVRQTDAEHEMLAWLHEAADEAAAVVLNPAAWSHYSIAVRDACAMLRGPLVEVHISNIHAREEFRHHSVVSAVATGVICGLGVDGYRLALHHLAARLAAGA
>NC_014391.1|WP_013285503.1|2473188_2473746_+|elongation-factor-P
MATTNDLKNGLVLNLDGELWAVVEFQHVKPGKGGAFVRTTLKNVLSGKVVDKTFNAGTKVETATVDKRTMQYLYADGEDYVFMDLETFDQITVPGGTVGEAANYLLPEAEATVATHESVPLYIELPTSVVLEVTYTEPGLQGDRSTGGNKPATVETGATVQVPLFITTGEKIKVDTRDGRYLGRA
>NC_014391.1|WP_174361785.1|2473769_2474180_+|transcription-antitermination-factor-NusB
MPARRKARKRALDVLFEADLRDRPPVEVLAGYLERIEQPRPDHLGYAVGLVEGVAAHLDRIDETIASYAEGWTLERMPVVDRNLARIAVYELLYVDEIDDAVAISEAVELARQMSTDDSPRFLNGILGRIAEYATR
>NC_014391.1|WP_013285505.1|2474242_2474731_-|transcriptional-regulator
MPSEYAKSLGARLRSIRQQQGLSLQGVEEKSNGRWKAVVVGSYERGDRAVTVSRLAELADFYRVPVSELLPDGSGVRHEPTSKIVLDLERLYDEASEDLAYVARYARAIQQQRGDYNGRVLSIRADDLRALAIVYDASPSGLIERLTEHGVLVADPRAFFAS
>NC_014391.1|WP_013285506.1|2475017_2475599_+|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR
MAYPPAAHSSPPRQPSVKVILAAADVSRVVDRIAHQILEKTQGAADTVLLGIPTRGVPLAHRLAARISTFEDVTVPVGVLDITLYRDDLRRHATRAVGPTDLPPGGIDGKRVILVDDVLFSGRTVRAALDALSDVGRPASVQLAVLVDRGHRQLPIRADYVGKNIPTALAENVKVTLAETDGSDEVRLYGGSL
>NC_014391.1|WP_013285507.1|2475657_2476584_+|aspartate-carbamoyltransferase-catalytic-subunit
MIRHLLSGADLDAGTATLVLDTAAEMATVAGREVKKLPALRGRTVVNLFYEDSTRTRISFEAAAKRLSADVINFSAKGSSVAKGESLKDTALTLQAMGADAVVVRHPASGAPHRLAEWVDGSVVNAGDGTHEHPTQALLDAYTMRSRLGRLDGLHVAIVGDVLHSRVARSNVLLLSTLGAKVTLVGPPTLIPVDIAAALATGTDVCYDLDAVLPDVDVVMMLRVQRERMGDSYFPSAREYARRYGLDGPRMRRLPEHAIVMHPGPMNRGMEITPEVADSPRSTIVEQVANGVSVRMAVLYLLLGGNNR
>NC_014391.1|WP_013285508.1|2476580_2477897_+|dihydroorotase
MTAYLITGVSIVGGEPTDLLIRDGVVAGTGRGLAADDATVIDATGLVALPGLVDLHTHLREPGREDAETVESGSRAAALGGYTAVCAMANTSPVADTAGVVEQVWRLGREAGLVDVQPIGAVTVGLAGERLAELGAMADSAAGVRIFSDDGHCVSDPRLMRRALEYVKAFDGVIAQHAEEPRLTEGAQMHEGEVSTRLGLTGWPAVAEEAIIARDVLLAEHVGSRLHVCHVSTAGSVEVLRQAKARGVRVTAEVTPHHLLLTDEVVSGRSELANNWSPAGSYDPVFKVNPPLRTATDIAALREALAEGVIDIIATDHAPHAVEDKECEWAYARPGMLGLETALSIALDVFGPRWDLIAERMSRTPARIAGLAGHGLDPAPGVPANLTLVDPAARRVVEPAELASRSRNTPYARMTLPGRIVATFLRGEPTVLDGKAVK

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Crispr_ID: NC_014391_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014391_5

4400743-4400831

Orphan

Consensus_repeat	Method
GTCGGCGGCCGTGCGCCGGACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014391_5

>merge|NC_014391|5|4400743-4400831|CRISPRCasFinder
GTCGGCGGCCGTGCGCCGGACCGCGCCGTTCCTGCGCAACGCCGACGGATCACGCAGCACGATCCGGTCGGCGGCGGTGCGCCGGACCG

>NC_014391|5|5|4400743-4400831|CRISPRCasFinder
GTCGGCGGCCGTGCGCCGGACCG	CGCCGTTCCTGCGCAACGCCGACGGATCACGCAGCACGATCCG
GTCGGCGGCGGTGCGCCGGACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014391.1\|WP_013287033.1\|4387038_4388400_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NC_014391.1\|WP_013287040.1\|4394394_4395630_-\|hydroxymethylglutaryl-CoA-synthase-family-protein	unknown	unknown	gnl\|CDD\|225959
NC_014391.1\|WP_013287035.1\|4389917_4390904_+\|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|130256
NC_014391.1\|WP_013287048.1\|4427630_4428392_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_014391.1\|WP_013287037.1\|4391768_4393025_-\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013287050.1\|4429680_4430220_-\|DUF1697-domain-containing-protein	unknown	unknown	gnl\|CDD\|377954
NC_014391.1\|WP_013287034.1\|4388595_4389834_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NC_014391.1\|WP_013287039.1\|4393204_4394398_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|131480
NC_014391.1\|WP_013287045.1\|4423228_4424107_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013287052.1\|4431611_4433096_+\|acyl--CoA-ligase	unknown	unknown	gnl\|CDD\|223395
NC_014391.1\|WP_013287049.1\|4428388_4429669_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|215608
NC_014391.1\|WP_013287046.1\|4424113_4424872_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|235938
NC_014391.1\|WP_013287042.1\|4395871_4396807_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375665
NC_014391.1\|WP_013287047.1\|4424868_4427076_+\|acyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|240093
NC_014391.1\|WP_013287032.1\|4386233_4386974_+\|thioesterase	unknown	unknown	gnl\|CDD\|225749
NC_014391.1\|WP_013287053.1\|4433239_4433653_+\|DUF4260-domain-containing-protein	unknown	unknown	gnl\|CDD\|379455
NC_014391.1\|WP_013287041.1\|4395626_4395875_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|376348
NC_014391.1\|WP_013287051.1\|4430346_4431588_+\|hydroxymethylglutaryl-CoA-synthase-family-protein	unknown	unknown	gnl\|CDD\|225959
NC_014391.1\|WP_013287044.1\|4417012_4423030_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|238429
NC_014391.1\|WP_013287036.1\|4390900_4391701_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444

Protein	Function_ID	Function_description	E-value
NC_014391.1\|WP_013287033.1\|4387038_4388400_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	1.97946e-179
NC_014391.1\|WP_013287040.1\|4394394_4395630_-\|hydroxymethylglutaryl-CoA-synthase-family-protein	gnl\|CDD\|225959	COG3425, PksG, 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism].	3.20907e-77
NC_014391.1\|WP_013287035.1\|4389917_4390904_+\|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	1.57104e-110
NC_014391.1\|WP_013287048.1\|4427630_4428392_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	4.38839e-32
NC_014391.1\|WP_013287053.1\|4433239_4433653_+\|DUF4260-domain-containing-protein	gnl\|CDD\|379455	pfam14079, DUF4260, Domain of unknown function (DUF4260). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 114 and 126 amino acids in length. There is a conserved GLK sequence motif.	7.5687e-44
NC_014391.1\|WP_013287050.1\|4429680_4430220_-\|DUF1697-domain-containing-protein	gnl\|CDD\|377954	pfam08002, DUF1697, Protein of unknown function (DUF1697). This family contains many hypothetical bacterial proteins.	8.2468e-50
NC_014391.1\|WP_013287034.1\|4388595_4389834_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.41761e-92
NC_014391.1\|WP_013287039.1\|4393204_4394398_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	2.60689e-14
NC_014391.1\|WP_013287052.1\|4431611_4433096_+\|acyl--CoA-ligase	gnl\|CDD\|223395	COG0318, CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	2.75486e-80
NC_014391.1\|WP_013287049.1\|4428388_4429669_+\|cation:proton-antiporter	gnl\|CDD\|215608	PLN03159, PLN03159, cation/H(+) antiporter 15; Provisional.	4.77103e-33
NC_014391.1\|WP_013287046.1\|4424113_4424872_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|235938	PRK07112, PRK07112, enoyl-CoA hydratase/isomerase.	7.503e-73
NC_014391.1\|WP_013287042.1\|4395871_4396807_-\|hypothetical-protein	gnl\|CDD\|375665	pfam18238, LnmK_N_HDF, LnmK N-terminal Hot Dog Fold domain. This domain is found in LnmK and is present in Streptomyces atroolivaceus. LnmK is a bifunctional acyltransferase/decarboxylase (AT/DC) that catalyzes first self-acylation using methylmalonyl-CoA as a substrate and subsequently trans-acylation of the methylmalonyl group to the phosphopantetheinyl group of the LnmL acyl carrier protein. LnmK is a homodimer composed of two monomeric double-hot-dog folds (DHDF). This domain is the N-terminal hot dog fold.	2.35073e-102
NC_014391.1\|WP_013287047.1\|4424868_4427076_+\|acyltransferase-domain-containing-protein	gnl\|CDD\|240093	cd04742, NPD_FabD, 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDPs are members of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	4.82454e-88
NC_014391.1\|WP_013287032.1\|4386233_4386974_+\|thioesterase	gnl\|CDD\|225749	COG3208, GrsT, Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism].	2.72856e-76
NC_014391.1\|WP_013287041.1\|4395626_4395875_-\|acyl-carrier-protein	gnl\|CDD\|376348	pfam00550, PP-binding, Phosphopantetheine attachment site. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of the anguibactin system regulator AngR has the attachment serine replaced by an alanine.	1.31458e-09
NC_014391.1\|WP_013287051.1\|4430346_4431588_+\|hydroxymethylglutaryl-CoA-synthase-family-protein	gnl\|CDD\|225959	COG3425, PksG, 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism].	2.36433e-104
NC_014391.1\|WP_013287044.1\|4417012_4423030_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|238429	cd00833, PKS, polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.	3.18429e-179
NC_014391.1\|WP_013287036.1\|4390900_4391701_+\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	6.61442e-17

>NC_014391.1|WP_013287042.1|4395871_4396807_-|hypothetical-protein
MNVLTPELELLGPDATTRTTVVRPGMCGPGSLFVGQVGDWTWDTVSALCDTNVYTARDADGMPTYLAFHYIHLRGGADLHVRGMTFGDVLRVDSRSFASGSESVLTLHEIRRGDRPGRVVDPDEFYAHPDPGCLYAQNFNRWVVRGPSGGNGDLRSASPPGFRHGHLPVLPARHSPRRAYAELRALGAEPDPSDPLDRLALDYPVDPSRDLNGVGLLYFASYFSIVDWASLRLWRHRGGTDAGFLRRIVLDQRMSYLGNADVGAVLRVRVSRRPGGDVPGADETVRVVLADRDTGRPLAVALSQTRTEGTT
>NC_014391.1|WP_013287041.1|4395626_4395875_-|acyl-carrier-protein
MSPSDEAVRRVVHEVIAEILPAVPGDRIPGDAHLRDLGADSIDRVEIILALRERLGVDEPLGSFSDLPDIDHLVAYLCEVTA
>NC_014391.1|WP_013287040.1|4394394_4395630_-|hydroxymethylglutaryl-CoA-synthase-family-protein
MNVGIEALNVYCGVASVAVPVLFEGRGLDAARLGNLMMTAKSVALPFEDPVTHAVNAAKPILDAMDEADRDRIELLVTSSESGLDLSKSIASYVHRHLGLSRRCRMLEVKQACYAATGALQLACGYLAAGLSPGAKALVIATDVSLVNENASYTEPAMGTGAAAVLLGDDPRVLDVDLGAFGTHSYETFDSARPGPTFDVADADRSLFAYLDCLTNAYAHYAEKVADVDFATTFAGLAMHTPFAGIVRAAHRKLAREHRLPDADADFARRVAPGLEYPRLVGNLCSGSVYLALASLIDHLRPDDPVRVGMYSYGSGCAAEFYSGLVDGRSTAEVGRMRIGEHLAGRCELTFDEYKRILADNADCLVPVADKRIDPGRYAEVLDRVAGARTLLACTGVRAYHRSYEWIGAGA
>NC_014391.1|WP_013287039.1|4393204_4394398_-|alpha/beta-fold-hydrolase
MTPGRDLAAALLAAGPLLRVLPPPVRVRCADPATAAALARLCDRLDVPAPTPVTDAADLGPFERVVSDLLDLDANPAPPPADEPRVVAEAREQDFTCRFRRTDVRTGDGVVLPTYAAGDPDRPPVLMVSACGMPARLAEGWAGRLSRDFHVLVPETRGLFADVDGFSADTGVVAQADDLLAVLDRFGLRRAHLIGLCGGAVLAVVAAARAPERVSSLSLWHGDFDLGDESPKTDHQQNLQALMAMAARSPQQAAAVHAVLTNTMLGVAPPRLAHLVTYPYATPELLRRYCRLNGAIMGTDLRPYLAGLTTRTLVVTSEDDHTAHPAGSRAVAARIAGSVLHVAEHGDHLSLFHAEESLVDLAARFVAGDDALGTRSPAEAGRRVPPVPTRGGEEVFP
>NC_014391.1|WP_013287037.1|4391768_4393025_-|hypothetical-protein
MTEFALDAPVLVRPYTARRDGDFAVIGDDSRQVYLSIPAEGLDLLEWLRDGATVGEAVRRFEATHEASPDADAFLQALADEGFLAPAGAHDPPPDAEPARPPRPGHLAWLSPQAARRLLSRPVLAVCGVIVGVAVAMAVDRPGLVPGPSSLMFHSHFWAYLLVVLGIAVIGVWLHELAHVVGARAAGTSARMTVGNQMYAIVAQTDLSGMWMASKRERFVAVLVGPLVDVIGAALLFITLWLNDVGVLGLPEPVRLVVAGVLFTSFIRLLWQTFLFLRTDFYYLITTALDTRSLMADTGAYLRNLVRRVLRRRLIDQSGVGRGEMRTIRIYAVVWVLGRVVALAVLFTATIPLLWFYLVRVVGFFRGDEMTGQFTWADVLALAMLSFLLDGGGTLMWLRSLRRSSRLRRRAPDRVLVE
>NC_014391.1|WP_013287036.1|4390900_4391701_+|ABC-transporter-permease
MNAVVLAFGEGVVVAKRNLRMILRVPEMLLNAAIAPAMMTLLFGFIVGGAIDAQGVPYREYLLGGIFVQAVLFGAVNTGTAIAADLRNGIVDRLMSMPISRSAVLVGRTTSDLVNSGVVITVTALLGLVVGWRSRTSLPEAALGFLILLAFAYALSWLMAVVGLASRAPEAVSSTGFTIAIPLGFLSNAYVPIDSMPGVLQPVAEWNPVSAIVQAVRVQFGNVDPSTAPDVWPLQHPVAASGLWIGALLALSIPLAIAQFRRSAGR
>NC_014391.1|WP_013287035.1|4389917_4390904_+|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein
MANAIVADGLRRQFDKVTALDGLDLVVPEGTITGILGPNGAGKSTAVRLLTTLLAPTGGRAEVAGFDVVTQAAEVRRVISLSGQHAAVDENLSGFENLEMLGRLLHLGARQSRQRADELLQRFDLVDAAGRRAKEYSGGMRRRLDLAAALIRTPRVLFLDEPTTGLDTRSRTALWDTIGELVSGGMTLLLTTQYLEEADRLADQIVVIDHGRVVAGGTPDELKRRVSGTSLEITVGPDADLTAAQTVLTSLGTGPASVDETAGRISVPAGDGVDTLLAGARLLRQAGIPVRDAALRTATLDDVFLALTGGPGRGTGDEPVKETVEEKQ
>NC_014391.1|WP_013287034.1|4388595_4389834_+|cytochrome-P450
MTTSEQPDLMSPAARETAYDTYAALRDTNPVSRVRMPTGQDVWLVTGYDECTSFLTDYHRFKTSPTVMPEGMEAPALPEAVVRLLGGSMGSVDPPEHTRQRRLVQQAFTPQYVERLRPGVQQITDQLVDGLLEREGRTFDLVEDFAVPLPLTVMSDMLGIPRADRDRFRLWSELLLSLDPTSAQSAPQGMSPAEVMAEIEEFVRYLDALIQRKRAEPGDDLISGMALAEADGERMSDDELLKMVALLVVGGLGTTQHLIGNMVLALFRNPEQLQLLRDKPELAPGAVEEMLRYHGPIEISFPRFAAEDTEIGGVPISRGEMVIGVLAAADRDPGRYPEPDRLDIERTANRHLAFGRGAHMCLGAPLARVEGQVAITTLLARMPDLRPAESLDETPWRPGLTLRGLTALTVEF
>NC_014391.1|WP_013287033.1|4387038_4388400_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MDLETTETERLRTLDQQRVWHPYTPTDAYLNAKPLVITHGEGVYLVDSDGNRYLDAGSSLGVNIHGHQRRELNEALAAQAAKIAHTTLYGMTHPGAAELADRLVRLAPEGIDKVLFLESGSSAVETAMKMAYSYWVFKGSPQRNKFVSMGGAFHGDTIGALSVGQMTILKNFYQPLLRETSSFAQPYAYRCGLCNNNCNLACADTLEEVLEREGDEVAAVLVEPRVQNVSGMIVARDGHLARVAEIARRYGVLLIADELGVGFGRTGPMFACQADGVSPDILCVGKGLTGGYMPLTATMASAEVFDAFRGDGKMLLSGHTFSGNPLAVAVALASLDLFEKDDLIRHGQAQAVVLAEELDKFRSVAHVGDVRQCGLLAAVELVADVETREPFPMELGVATRITERCRELGMIIHSAPSDTIVIVPPLVMTEEELRTMARILLQATQEVVASLPA
>NC_014391.1|WP_013287032.1|4386233_4386974_+|thioesterase
MSNQWIKGPADRDAPMLLYCVPHAGGGGSFFRPWRAALEPYLGVCPVVLPGRESRLREPPYTSIDHLVPPLAAAISAHADRPYALFGHSMGAVVAYETARRLSAGPGGGPARLFVSGRRAPHLPARRPDRHTLGADEFLPAVAALGGTPDEVLRRHDLMALFLPGLRADFAVNETYRQLPGPPLRCPVSAFTGDADPEVDVVEMRSWADVTSAGFSLRVFSGGHFYLAGPPAELAEALLADLAVRS
>NC_014391.1|WP_013287044.1|4417012_4423030_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTQQTDPAHAVVLSAADPERLRRSAHRLREHVSTADPALDLADVAYTTQVGRMPLPHRLAVRCASVADLVGGLDAYLRGEARDGVLHGVAGAPFAPAAAPTDADAAADWVGGGLVDWRRYWPGPRPRVPLPGYPFGAAPPAPPAARPRDPAGSLRAYLVEVYAEVSGLPAESVDPLLPLTELGLSSFLVTRLTARLENDLGERSRTLFFEHATLGEVAAALAAAGRTAPAGAAPAEPAEPAESAAPAARTESVAPAESAAPPAADVVPAPAVAVEREPEEERETEIAVIGVAGRYPRSPDLDAFWDNLAGGRDCVTPHPPERARPGWPTHLMDGGYLDDVDRFDPLLFGITPRDAALMDPQERLFLEVTWAALESAGYTRARLRERHHSSVAVYAGAMWNEYPLFGAERTLRGVPQDSGATLGGIANRVSYCFDLHGPSLTVDTMCSSALVALDLAVQSLRRGEAELAVAGAVSLSLHPNKFIQQHRMKLTATDRRSRTFGAGGDGFVPAEGVGALILKPLRRALDDGDPVHAVIRGTAVVHAGRTNGYIVPSPVAQADVVRRALRDARTGPAEIGYVEAHGAGTALGDPVEIDGLTRAYRDAAGTDLPPGSIPIGSVKSTIGHTEAAAGLAGLTKVILQLRHGVLAPSLHADELNPNIPWDAVPFRVQRQRAEWTGPRVAGVSSFGAGGTIAHAVVAAPPARTRPAAPPGPQLVVLSAYDEDRLDEVVRRLVAYLRRDRGPSTADLVAAVRRIAAGEHPGSAADHAAALLAHDGPALADIAYTLQVGREPLRQRLAVVVEDVATLCERLTAYRTDPAVLRGRAPAAPDPDAVPPAGASLTDLARHWVAGGAVDWAALHEPGRTVVDLPAYPFARMRCWAPEDTPAGVSSGTQAPTVAAAPGAEVPLYVKGWEPDPDPGPAASPVAGVMLCVGGSPDLVARLGGLAVRDVADLAAVLSRVPDVGGLVGLPGGPGWETRVRMVQRLLAERPTTPLRILETAVDDVRTAGFVKVLGAEYARVTATVLHTDRTGDDADLATRILAEWVRADAYGEVRYADGRRYRPRLDLVPAPHAPLRCDPDGAYLVTGGTRGVGALVARHLAGHGARSIALVGVHADTGVADDLRARGVRVLQHAGGFPGVEEFLRQVRAELGPLRGVVHCAGVESRGNPAFLHKDLADVRAVMAPKLDGFETLAPLCADDPLDFFLVFSSVCATVTGLAAGVSDYAAANIAVDELVRARIAAGRTEFRSVDWPQWAQTGSTSGRPNPCAPAGLAPLDDAAGLRVVDRVLALPAGAVVLPCPPLGDAPDPDALLRLRPRRPAPTSPPVVAGAPAAGTPAPGSATASVPAPASVPAPASVPAPASVPASASASIPAPAQALTTGTATAPAAPGGPAAPPGWLVGIFSAALGIPERDLDPTVEFGDLGVDSVLLGELLIRIEERLGTHLDPATLLLHPTLERLTAHLGVQAATPEPEPPTAPEAVNSPGPVAAPVPVTPPDAVTAPVPVTAPVPVDEPVPTAAQAAVVAGGGARPDLDRRVAVIGMACRFPGATDVVTLWDNLLHGRCAVTEVPAERWDHRRWYSPEPGLGRSISKWGGFVEGIEWFDPGYFDMSDDEARCLDPAIRMFLEGTAECLAEAGYAPDELRGRRVAVVAGARLSDYGRRVPIRTDVLRSDQNFIAARVAHHFDLRGPNLVVDSACSSSLVAVQVACRSLLAGESELAVVGGVEVLLDPETYLDLSAARALSPTGRCWTFDERADGFVPGEGCGVVLLKPLAAALADGDRVHAVIDGVAVNNDGHTMGVTTPSPAAQADVVRQALAAAGRRPADITMLEAHGTGTLIGDPIELRALNDVFGDRPGGRIEIGSVKSNLGHLLSAAGMAGLFKVALALEHGTIPPTLFCDTPNPRFDFDRSPLHPTTEPVGWPAGRERVAGVSSFGLGGTNAHLVLSGAPPGPVRRAPLPRPVFRRRRLWLDGDGPAGAPPPARPDTGEPLTASLLRLQLVTTD
>NC_014391.1|WP_013287045.1|4423228_4424107_+|hypothetical-protein
MTTTVEPYRALNQSSLPLERVLHTLNSGFILHRVGQMAYGFAAEGRQFSVDLLQYINTSQEGVATSFAFEEVFGGRDRMHWFIHLKSPQDYRILLNMVDHDLEFRRISDEDRLPHKGGGNWDRIFVHRSLHEDVLVPQHGMDHDGDDAEPATFVPPASSQLNQPPEQQINSATAGAIVMRTSDVKYEFREEGRMYAAHWQHFVNERLAGRVTATLYEQTWGQQDHLFQLIHLRSVDDYHELRELERGKEMATEVFGRRRLHESKGGGTWDRLFIEGSIRDTLLLPQVPSGAA
>NC_014391.1|WP_013287046.1|4424113_4424872_+|enoyl-CoA-hydratase/isomerase-family-protein
MAYRTIELRREPGLLRVTLARPERRNGIDDETLRELHAALDEAEGDAACRAVVLAGRDGVFSTGMDFQSAAGDGGASDGGAAFFALLERFTTVPRVVIAQVDGQVAGGGVGLVAASDFVHATARSTFALPEALWGLLPCCVLPFLVRRVGFQKAYAATLSTQTIAAAEAYRIHLVDEVAERPETVLRQLLFRLNRLDPVVVGDAKRYFRAFSGVDDRLRDHAVTEFGRLMSAPAVRQRITEFVAHGRYPWER
>NC_014391.1|WP_013287047.1|4424868_4427076_+|acyltransferase-domain-containing-protein
MIAVRAWVFPGQGSQHPGMGEGLLDRFPAECATAERLIGVPPAQLCRDARGEYLGRTRYVQPAVFLVSVLAARAALADGRPPPEVVAGHSLGEYAALHLAGCLDFDSALSLVVRRGRLMESVTGGGMVAVLGLPLSRVTELLAGIPDVDLANHNLPDQFVLAGSTAGIRAVVDAVPRLGTGRCVPLAVSVPAHSRFMAGAAEAFAVALRDVTPGPPSIPVVSNVTGAPHVPGEIPGTLLRHFVEPVRWWDTMCLLARSGVTEPVEVGPGEVLTKMWRRAAGSLPAPAPGGPLAPAAPVPPPAPVPPPPPATSVAPAAPAALPVTAPAAPVARGPALGPPPATASRPRPAGSPGLRSDYGIRYACLAGSSPFGVTSPAFLRRLSEAGLLGFFGAQGLAPPEIRAALAELRDVRRYGMAWPSGGDERALCDLYLAHDVRHVEVTGPLAVVSPQLVRFRYGDGPRQVLVRAPDLATAVRFLRPADPATVRALAAAGHLDGGAAGAAAREAVATDVAVERDAHALVPALVALRDREAPGARIGVAGVGTPAAVAAAFALGADFVVTTTVNQCTAEAATSDAAKDLLAALDVTDIREAPDPDLFELGARSPVAHRGTLFAARAEELYRMFLRYDRLADVGPRRLAELERTHFGRPLDDVRADLGVAGRDDRRVLASVCAAYCREATAAALRGTPGQRLNYRVPASTDVGAFNRLVAAEPLADWRARHAESVTERLLSEAN
>NC_014391.1|WP_013287048.1|4427630_4428392_+|Crp/Fnr-family-transcriptional-regulator
MRIAGATTSLRNELHRLIRDDPTFAVRTHVPRGGAAYNSGDHDLRMYLVEVGQFKTIASSADGKQCLLSIHTRGDMFGELGLLGGPRHDTARAMRDSVIRRVNSAKLFDLLSSDEQLNWHFTRFLMAKLLDQQQAITQLVTMDSEHRLAATLLRLARKVGRRLNLGMQIDAKITQEELASMVGTTRSRVGLFLKHFRAAKLVDQLPGGYLLINEPALTRYVECGQYEPARWGAEPIRPVNGARLLRGDRELSA
>NC_014391.1|WP_013287049.1|4428388_4429669_+|cation:proton-antiporter
MSAVLVLLHGAALLVALLLVGGTGRAVARLLRQPPVIGEIVAGLLVGPALVLFAGHDGLAAVLPEDIRALLRLVAEGALVLFLVGLARELRVGPARDDRRLAWVTAGALVPALACGVLVALWVQFVAGPAVRGDAPMPAFVLGVAVTLSITAVPVLARLLTERGLTETTAGALALAAAVVVDVVGWLLLSLAVGLGAGDPATFGRAMAVLAGALLLAGGIRWVLRRARAALWCGRWPAASAVVLGVVALVVGFGVHLLGLTAVFGAILVGLAVPPGEPWDAPTAAVSRLGRSLLPIFFVSAGLTALTGAVASTPWSLVVVVLVLGLAGKIGGGYLGSRLGGCSPAEATRIGILLNTRGLTELIVLQVAFQAGILSPPLFLALLIMALVTTLLTGPLLSLADRFVRAADAGDSASGAVSGPSMVSPR
>NC_014391.1|WP_013287050.1|4429680_4430220_-|DUF1697-domain-containing-protein
MTRYVALLRAVNIGGGSSMVMTELKEVFVSCGFDGVATYIQSGNVVFGCPETDEVAILAEIDRGIKQRWGRDVPVLLRSLDELDAMIAANPYLDVQTDHTKLLVTMLSGDPGADKQAALAAPPGESGTLTLLGRDVFVHVPDGYGRSKLSNAFVEKKTGVVGTTRNWRSVLKLRDMAAS
>NC_014391.1|WP_013287051.1|4430346_4431588_+|hydroxymethylglutaryl-CoA-synthase-family-protein
MITTAVGIEDLHVYPGRAYVDVPSLFEARGLDPSRLPNLMMRRRSVSLPCEDQVTHAVNAARPLVDALSPEQREAIELVVVATESGLDFGKPISTYVHDLLGLPPRCRSFEVKHACYGGTAALQSAAAIIAASPAPDARALVIATDIAGVAAAGSYFEPSEGAGAVAMLVSRTPDVLRLDLGASGYHTQEVMDTLRPRPDVDVVNSDLSLLAYLTCLERCFAAYRDRVEGADIVTTFDHLVFHIPFAGMVKGAHRTLLRKTKRMAPADIDRDFAARVAPSLSYTSQIGNLYSGSLYLALCSLIDHADFTVARRIGLFSYGSGCGSEFFSGVVTERAAGRLAARPLARAVEERRRLTVAEFDEWSRHTADRAFGVRDAVLDTGPYRSVLDSHVAGRGLLLLDRIEDFHRVYRWS
>NC_014391.1|WP_013287052.1|4431611_4433096_+|acyl--CoA-ligase
MSVPTSAVVVPDLLRHRTGLMPEQEAINVRGKTAITYRDWDRRSNAVARAVLDRLGGTGRGARVALLFGGDDWIDYAVAYLGVLKAGATAVHVNDTMPAVELRRRFDQCAVAGVIRGAALPPWRDDAGRWSVVVADLDQGDSAAVDTGVTPEDISDILYTSGTTGPAKPFTNPHGNLTYGRGSAALGQLVDPAPLLAPMPLGTTSSATTVAVLATTTPSPLIVCSPDDPEEIARLLATHGCATLILTPWTAIRLAAIRPQDRYDLGSVKTIGNASAIMPPRIARDLLAAMPNATIANAYAQSEAVPAIILGNVDPDRPMWLGRPGRGTEMRVVDQQGEPLPPGELGEVWLRCEAPKRLYLDQALNARVHAGGWTRTRDLGRATADGELFLFDRMTDVITTDGKLVSSLEVEAALYDHPSVREATVVALPDPEHGEIVAAVVAADPALDDATLAAFLAERLEPHQVPARIHRLDALPRGGTGKVLKYQLRQRFGG
>NC_014391.1|WP_013287053.1|4433239_4433653_+|DUF4260-domain-containing-protein
MPQLNPVAAQRVEAVAVAALAVVVTVAAGYPWWSLLALFLVFDLSMLGYLRGPRVGAVCYNVAHSYTLPAALGAVAVAAAASGDRIDWLGVLAVAWAFHIAVDRALGYGLKTTEGFEHTHLGLIGKARRAGSSTDER

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Crispr_ID: NC_014391_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014391_6

5375044-5375140

Orphan

Consensus_repeat	Method
TCCGGGCCTACCGGGACGGGCGACG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_014391_6

>merge|NC_014391|6|5375044-5375140|CRISPRCasFinder
TCCGGGCCTACCGGGACGGGCGACGGTGCGCCCGGGCGAGTCGGGTCCGCGCCGTCCGGCATCCGCCGGCCGTCCGGGCCGACCGGGACGGGCGACG

>NC_014391|6|6|5375044-5375140|CRISPRCasFinder
TCCGGGCCTACCGGGACGGGCGACG	GTGCGCCCGGGCGAGTCGGGTCCGCGCCGTCCGGCATCCGCCGGCCG
TCCGGGCCGACCGGGACGGGCGACG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014391.1\|WP_013287889.1\|5375416_5375923_-\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NC_014391.1\|WP_013287896.1\|5383947_5384334_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013287887.1\|5374405_5374840_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013287882.1\|5371435_5371819_-\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013287884.1\|5372649_5373411_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_014391.1\|WP_174361732.1\|5370583_5370892_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_014391.1\|WP_013287879.1\|5369566_5370496_-\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274648
NC_014391.1\|WP_013287878.1\|5368918_5369374_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_014391.1\|WP_049794843.1\|5371934_5372618_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013287894.1\|5380067_5381303_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366721
NC_014391.1\|WP_013287897.1\|5384430_5385615_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NC_014391.1\|WP_013287898.1\|5385619_5386630_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_014391.1\|WP_013287886.1\|5374087_5374396_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226614
NC_014391.1\|WP_013287881.1\|5370895_5371426_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176908
NC_014391.1\|WP_013287885.1\|5373569_5374037_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176904
NC_014391.1\|WP_013287891.1\|5376983_5377499_-\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013287892.1\|5377575_5377968_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013287895.1\|5381295_5383431_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_014391.1\|WP_013287893.1\|5378312_5378987_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_014391.1\|WP_013287890.1\|5376059_5376851_+\|AAC(3)-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|376807

Protein	Function_ID	Function_description	E-value
NC_014391.1\|WP_013287889.1\|5375416_5375923_-\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	1.8007e-44
NC_014391.1\|WP_013287884.1\|5372649_5373411_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.95646e-10
NC_014391.1\|WP_174361732.1\|5370583_5370892_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	2.1275e-18
NC_014391.1\|WP_013287879.1\|5369566_5370496_-\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274648	TIGR03560, F420_Rv1855c, probable F420-dependent oxidoreductase, Rv1855c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity].	2.84655e-112
NC_014391.1\|WP_013287878.1\|5368918_5369374_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	6.11356e-05
NC_014391.1\|WP_013287894.1\|5380067_5381303_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	3.5072e-42
NC_014391.1\|WP_013287897.1\|5384430_5385615_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.23031e-56
NC_014391.1\|WP_013287898.1\|5385619_5386630_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	1.06478e-31
NC_014391.1\|WP_013287886.1\|5374087_5374396_+\|hypothetical-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	0.00899985
NC_014391.1\|WP_013287881.1\|5370895_5371426_+\|SRPBCC-family-protein	gnl\|CDD\|176908	cd08899, SRPBCC_CalC_Aha1-like_6, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	3.83236e-38
NC_014391.1\|WP_013287885.1\|5373569_5374037_+\|SRPBCC-family-protein	gnl\|CDD\|176904	cd08895, SRPBCC_CalC_Aha1-like_2, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	2.44811e-65
NC_014391.1\|WP_013287895.1\|5381295_5383431_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	7.51755e-81
NC_014391.1\|WP_013287893.1\|5378312_5378987_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	4.17491e-07
NC_014391.1\|WP_013287890.1\|5376059_5376851_+\|AAC(3)-family-N-acetyltransferase	gnl\|CDD\|376807	pfam02522, Antibiotic_NAT, Aminoglycoside 3-N-acetyltransferase. This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyze the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.	3.5339e-107

>NC_014391.1|WP_013287887.1|5374405_5374840_+|hypothetical-protein
MAVTAAGVFRRTPQERADQRLAWERADQPFFAAGACHILAWVCRDTYPDRPIGLAGLRFAGQSQVFHVYATWADRAFDHAGWNPEADLLAANREFERRPLERIAIVDDLATFCREHFSRMPHQYWGDPLPRARDYVNRHAPPWE
>NC_014391.1|WP_013287886.1|5374087_5374396_+|hypothetical-protein
MTGQRAGRGGRRGSSRRAGLDAERFDEAWERVNERGRAAGRDRMQQLRIKSVLAVQAGLAAALAWAAARWLTGMPSPIFAPDAGVQVHVVSSVVVHGRAAFG
>NC_014391.1|WP_013287885.1|5373569_5374037_+|SRPBCC-family-protein
MSRIDRGSRTIAAPPAAVYDALVDRAALEAWLPPDGMRGRIERWDPRPGGGFRMVLTYLDPAGSPGKTSDATDVVDVGFAELVPARRVVQTAVFQADDPAYAGTMTMTWHLAAAGDGTAVTVTATGVPPGIDQRVHEEGIASSLAHLAAYLEPGA
>NC_014391.1|WP_013287884.1|5372649_5373411_-|GNAT-family-N-acetyltransferase
MPVRQHLHDSLLLGDDDTPLARMRLRDDDGTAVAADVRPLPEAPLTRLVAQVRRDLAGHRLETPDEALAAALVADGLKLDRAATDMRHDLTGVPEPVALPDGWSLGAPGWDDDLAEGLDAAYGPDHPDGRWQPSDTEEVRAMFDTGEPVPPLVPASARLIDPDGRSAGHVLCAGPVPWTDDDCVWILNLGVAPRAQRRGFGRALLVHALRGAREVGLPSVGLSVVDGNPARRMYDAAGFRVLTRVLTVRIPDA
>NC_014391.1|WP_049794843.1|5371934_5372618_+|hypothetical-protein
MSRPLPRLVEAEAFADVPAERLLAVLEAVTMVLTLPHRAAERVDALVVPTGQGEDWRLTDAIRAWETGPALRHLLVANTDSAERTYRPLTLDRLRGLGLRRTGGVVLQAEPVTGTGRQATWIAEQVRALGVGSVALVVSPYHLVRVYLTVLRACDDAGLRIPMVPLPVAVAPDAPVPETGAAGYDLVAGEVSRLLRYPGQGWIATPERLRDYLRWLWSEHRPLLTGA
>NC_014391.1|WP_013287882.1|5371435_5371819_-|hypothetical-protein
MTTRRTLLGGLLLALATAGAWVAWLSWESGWTVDPQTGDMSGPYAVWQVAAAVLTLGALAAVGGWWLNIWLVATVMTVAFTVPWAVHAASTDDTGLWAVGAALVAIGTTIGTTLVGGAAGWLRRRTA
>NC_014391.1|WP_013287881.1|5370895_5371426_+|SRPBCC-family-protein
MDRDTFRPGPLARVHLEPANDRWDLVFVRALRHPPETVWAALTDPDQLAAWAPFLADRDLGRTGDAVLSTVDGEQAHPAPARVLRADRPHLLEYTWGDDLLRWELAPTGDGTTLTLRHRVGRPDLAPMTAAGWHLCLDVAAHLLDGDPVGPIRGAEAKDFGWAELRDAYAERLNRD
>NC_014391.1|WP_174361732.1|5370583_5370892_+|metalloregulator-ArsR/SmtB-family-transcription-factor
MTVDAFTVLAEPSRRRILDRLRRAESSVGELVDALGMSQPTVSKHLRVLRDAGLVTCRTAAQRRIYRVNVAPLRAVDDWLGPYRSMWTAHLDALERHLDSQE
>NC_014391.1|WP_013287879.1|5369566_5370496_-|LLM-class-F420-dependent-oxidoreductase
MELRIFTEPQQGATYDQLLAVARRAEETGFAAFFRSDHYLKMGSVSGDPGPTDAWTTLAGLARDTTRIRLGTLMTAATFRLPGPLAITVAQVDQMSGGRVELGIGTGWYAEEHSAYGIPFPSLGERFDRLEEQLAVITGLWSTPAGSTFDFPGTYYPVSDSPALPKPVQRPRPPILLGGMGPKRTPRLAARYADEFNLPFASVEDTVAQFGRVRDACAQIDRDPSTMTWSNALVLCCGRNEAEVKRRAEAIGRDPAELRANGAAGTPAEVVDTLGRYAEAGSSRAYLQVLDLTDLDHLELVAAEVMPQL
>NC_014391.1|WP_013287878.1|5368918_5369374_+|hypothetical-protein
MSSYRDPSLRGDVYPSEEEIDPTGVDPDAAEMPPAAVGMAPAAAGMPPAAVGVTPAAVGMGPAATAPVPGPTPEPEPDPVPHPGPPPRQASGRSIVTRHLDGSVEVVTDLDGDGVADVVQVDLDGDGVPDVTYLDSNRDGRLDTVRRATAS
>NC_014391.1|WP_013287889.1|5375416_5375923_-|SigE-family-RNA-polymerase-sigma-factor
MDEDERAVLAEFVASRAPALIRVAYLLTGDRSSAEDLFQSALSKIIPKWRSIRHADPEGYLRAVMYREQVSWWRRLRRRRESPAGVHEPVVADPAGGTDLRLALRAALWELPPAQRTVVVLRYYEDLPEAQVAELLGCSVGTVRSRTHRAVTRLRQILPDSELLEMRR
>NC_014391.1|WP_013287890.1|5376059_5376851_+|AAC(3)-family-N-acetyltransferase
MDQTAPHTVSSIAYDLRALGIVPGDVLLLHSSYRSLGFVAGRTEAVVRALLAALGPEGTLVVPTHTPENTDPAEWRHPPVPEAWWPVIREQTPGFDPACTPSRWMGAVAETVRTWPGARRSDHPQVSFAALGAHAADVVEGHRLDDALGEHSPLGAVYRLDGKVLLLGCDHSSNTSLHLAEWRQASPPRAVTGSAVRLPDGTSRWTTWTDVVTDEDDFDRLGADFEATGGATTGQVASATARLMRQRALVDFATAWMATNRAH
>NC_014391.1|WP_013287891.1|5376983_5377499_-|hypothetical-protein
MREIVGVARRCQGAADRCTAVYGCRVNRRLWVVSALAVTALLALPVTVVGVHVTHPRDEDGYLAYLKQYGDRQNGRPLAVLPPTADLVAEGDAACDWLREQPYALWRHDPEYRELVVYERYVRQVENRLPAWGNELPDRRSVTGAAWTHLCPAEWELRQPRRNPFAPKPPD
>NC_014391.1|WP_013287892.1|5377575_5377968_+|hypothetical-protein
MVAEVPPTYTCCEDLDVDKPYQPGQTLTVHWTVESPDEPGSTSPQVELTARLTGPYGTVDDLKAASAVPGLVTFTATPVRPTGTPGERPVSTIVIGPDAEPGFYDLVTSVIDGGNATSSGSSIVRVVPER
>NC_014391.1|WP_013287893.1|5378312_5378987_+|hypothetical-protein
MGYDVTVRRFGLYVAVAAMLLTASACGRADETPGTPTAVAASTDTESPTPMPSAPTATPSLAPEPSPTLRPSQTSRSSGTPRSSTAPAAAPTTRKATQVATTSSKAACTTVRGPLEKAIAGLIILVGVASSSTVEAELVNARAEASTRLVNLEAVANRVAGEQTDRTLRKKFQVLTMAAGRKDVEVRSIKPKLEYAEAIVKVASDTGDLESAVDKLEPDCGRYW
>NC_014391.1|WP_013287894.1|5380067_5381303_-|FAD-dependent-oxidoreductase
MPDTDVVIVGGGLAGLAAARRLHRAGVPWRLLEAGDRLGGRVATDRVDGFLLDRGFQVLNTAYPRLTGLVDVGTLTMGWFTSGVLVRRGDRLERLVNPLREPTGAPGTLTAGIGSLTDRLRFATLAAGYATVPVGRLLDTPETSAEKALRRAGLSDAIIEELLRPFLSGVLLDRELATSSHVLAVVMRSFARGRIGLPADGMQALPKALAAPLPAELIELNTPVTDVAPGRVRTPSGEITCRAVVVAVDPPTAATLLPGLPRVRMHAYTTYYHRTDTAPLDEPILLLDGDRRELIANTVVVSRAAPTYAPGGQHLVATSVVGPQAPPEPVIRRELDRLYGRSTADWTHLTTVAVPDALPAAPPPQGRLRKPVVLGDGLYVAGDHRDSPSIQGALASGWRTVGAVLAELRRG
>NC_014391.1|WP_013287895.1|5381295_5383431_-|MMPL-family-transporter
MAAGRSRWTATLIAVAVVLGWLIVGGIAGPYSGKLGEVSTNDNASFLPADAEATRAQDLAAGFVDRETTPALVVYERPGGLTPADQQRIRTDAARFAEVPGVVGPLPPPVVSQDEQAAQVIVPIDSSEGEQIRSVVERLRDIAGPDRDGLTVDVAGPAGLLGDLIEVFGAIDGPLLLVTLTVVLVILLVVYRSPVLWIFPLLAAGMSYSLAAVFVYLLADHDIVKLNGQAQGILTVLVFGAGTDYALLLIARYREELHRHERPWDAMRTAWKGAAPAIIASGATVIVSLLCLLLSSFNSNRALGPVSAVGIAATLLVMLTFLPALLVLGGRWAFWPRRPRYDQADPRTEHGIWGRIAGFVARRARTVWVVTAVVLAALAIGVTQLGATTLGQSQLFTQRTDSVAGQEVIDRHFPAGTGSPATIFTTQGTARQVAQVAQGVPGVASVLPLGERGENAPPDPNAPPKVVDGRVQLNVTLADPPDSNGAERTIRDLREAVHRVPGADAVVGGFTAINVDTADASVRDRDVIIPVVLLVIAVILALLLRALVAPVLLIATVVLSFLATLGLCALLFRYVFDFPGVDQSFPLFAFVFLVALGIDYNIFLMSRVREESVRRGTRAGVLAGLAVTGGVITSAGIVLAATFSALAVLPLVVLVELGVAVAVGVLLDTIVVRSLLVPALAYDIGPKVWWPGRLSRSHREGDRAGPGVDRA
>NC_014391.1|WP_013287896.1|5383947_5384334_+|hypothetical-protein
MRGKIMFLGGLAAGFVLGARAGREKYEELVVRGRKVLDHPTVQEAAGVAQAQATRLYSEGKDKLGQTKLGEKLATNGGKPGMTDADKPFAGTPAAVGSRSANGTGSTSASGSTTTGTSTKPSSTGNTL
>NC_014391.1|WP_013287897.1|5384430_5385615_+|ROK-family-transcriptional-regulator
MPMVGPETADQARLLRLLRDDGPRSRVELADLLGLPRARFAAEVDRLTTLGLVETAGPAASRGGRRSSLLRIGAQVRFGAVLVGDGLLRVALTDGELNPLARHDEPVDVRLGPDVVVGRIVELLGKLRVEAGLSSLTGVGVALPAPVEVRDGTPVSAPALPGWHRFPVRDTLAAELGCPVQVDNDANAMALGERHAGTGRPFDDFLYVKLGEAIGCGLVLAGALYRGAASGAGDIGHFQLTEDGPLCGCGNNGCVEAYCGDVALVREAVSAARAGRSTALADRLAAAGTLSVADVAAAATEGDPAAQTLVRDAARRLGRVLVGLVSFVNPAIVIIGGAPGGIGPVLLAEIRGVVYRRSTPLATGSMPIVLSDLGDTAGLVGAARLVSDQVYAAR
>NC_014391.1|WP_013287898.1|5385619_5386630_-|sugar-phosphate-isomerase/epimerase
MARPITLFTGQWADLPFDEVCRLAAEWGYDGLEIACWGDHFEVDKALADDSYVERKRATLAKHNLQVFAVSNHLVGQAVCDHPIDERHQDILPARIWGDGEPEGVRQRAAEEIKDTARAAAKLGVNTVVGFTGSSIWHTVAMFPPVPPAMIERGYQDFADRWNPILDVFDEVGVRFAHEVHPSEIAYDYWTTKRTLEAIGHREAFGLNWDPSHFVWQELDPVNFIFDFADRIYHVDCKDAKVRTGDGRRGRLSSHLPWADMRRGWDFVSTGHGDVPWEDCFRALNAIGYDGPISIEWEDAGMDRLVGAPEALQFVRRLAFDAPSAAFDAAFSSSRD

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Crispr_ID: NC_014391_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014391_7

5509728-5510009

Orphan

Consensus_repeat	Method
GCCNNNGCCGGGNNNGCC	CRT

5 spacers

The CRISPR arrays of NC_014391_7

>merge|NC_014391|7|5509728-5510009|CRT
GATCGTGCCGGGCCCGCCCGCGCCGGCCAGACCACTGCCGTACTCCGGGGTGCCCGAGCCGGGGGCGCCACCGAGCTCGGGGATCCCCCCGGTGGTCGGCGGGGTGTAGGAGCCGCCGCCGGGGATGCCGCTGCCGGGCCCACCCGGGGGCGGCGTGAACGAACCGCCGCCGGGCGTGCCACCACCGATGCCGGTGCTGCCGATGGACGGCATGGGGCCGCCACCGCCGGGCATGCCGCCGCCGGGCGCACCGCCACCCGGCAGGCCGCCGCCGGGCACACC

>NC_014391|7|1|5509728-5510009|CRT
GATCGTGCCGGGCCCGCC	CGCGCCGGCCAGACCACTGCCGTACTCCGGGGT
GCCCGAGCCGGGGGCGCC	ACCGAGCTCGGGGATCCCCCCGGTGGTCGGCGGGGTGTAGGA
GCCGCCGCCGGGGATGCC	GCTGCCGGGCCCACCCGGGGGCGGCGTGAACGA
ACCGCCGCCGGGCGTGCC	ACCACCGATGCCGGTGCTGCCGATGGACGGCATGGGGCC
GCCACCGCCGGGCATGCC	GCCGCCGGGCGCACCGCCACCCGGCAG
GCCGCCGCCGGGCACACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014391.1\|WP_013288011.1\|5502752_5503067_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NC_014391.1\|WP_013288024.1\|5522697_5524032_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NC_014391.1\|WP_013288022.1\|5521624_5522065_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NC_014391.1\|WP_013288008.1\|5500435_5500885_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NC_014391.1\|WP_013288005.1\|5498228_5499014_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180240
NC_014391.1\|WP_013288019.1\|5515459_5516167_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NC_014391.1\|WP_013288014.1\|5507827_5509288_-\|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl\|CDD\|274856
NC_014391.1\|WP_013288009.1\|5500944_5502396_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237045
NC_014391.1\|WP_013288020.1\|5516324_5519471_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235681
NC_014391.1\|WP_013288016.1\|5510787_5511225_-\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_083395316.1\|5506778_5507498_-\|DUF2344-domain-containing-protein	unknown	unknown	gnl\|CDD\|274865
NC_014391.1\|WP_041799328.1\|5499222_5499687_+\|DUF4383-domain-containing-protein	unknown	unknown	gnl\|CDD\|379556
NC_014391.1\|WP_013288012.1\|5503369_5506648_-\|Rne/Rng-family-ribonuclease	unknown	unknown	gnl\|CDD\|273254
NC_014391.1\|WP_013288018.1\|5513586_5515455_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_014391.1\|WP_013288017.1\|5511395_5513381_-\|TIGR03960-family-B12-binding-radical-SAM-protein	unknown	unknown	gnl\|CDD\|188475
NC_014391.1\|WP_013288010.1\|5502486_5502741_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NC_014391.1\|WP_013288021.1\|5519869_5521429_-\|alkaline-phosphatase-D-family-protein	unknown	unknown	gnl\|CDD\|226070
NC_014391.1\|WP_013288023.1\|5522126_5522552_-\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NC_014391.1\|WP_013288007.1\|5499772_5500432_+\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_049794893.1\|5524104_5524455_-\|DUF4233-domain-containing-protein	unknown	unknown	gnl\|CDD\|379420

Protein	Function_ID	Function_description	E-value
NC_014391.1\|WP_013288011.1\|5502752_5503067_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	5.97499e-45
NC_014391.1\|WP_013288024.1\|5522697_5524032_+\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	4.0757e-10
NC_014391.1\|WP_013288022.1\|5521624_5522065_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.31477e-24
NC_014391.1\|WP_013288008.1\|5500435_5500885_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.75954e-15
NC_014391.1\|WP_013288005.1\|5498228_5499014_-\|hypothetical-protein	gnl\|CDD\|180240	PRK05759, PRK05759, F0F1 ATP synthase subunit B; Validated.	0.00138853
NC_014391.1\|WP_013288019.1\|5515459_5516167_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	9.39156e-52
NC_014391.1\|WP_013288014.1\|5507827_5509288_-\|type-VII-secretion-associated-serine-protease-mycosin	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	3.54057e-83
NC_014391.1\|WP_013288009.1\|5500944_5502396_-\|GTPase-ObgE	gnl\|CDD\|237045	PRK12296, obgE, GTPase CgtA; Reviewed.	0
NC_014391.1\|WP_013288020.1\|5516324_5519471_-\|isoleucine--tRNA-ligase	gnl\|CDD\|235681	PRK06039, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NC_014391.1\|WP_083395316.1\|5506778_5507498_-\|DUF2344-domain-containing-protein	gnl\|CDD\|274865	TIGR03936, radical_SAM-linked_protein, radical SAM-linked protein. This model describes an uncharacterized protein encoded adjacent to, or as a fusion protein with, an uncharacterized radical SAM protein.	3.50603e-69
NC_014391.1\|WP_041799328.1\|5499222_5499687_+\|DUF4383-domain-containing-protein	gnl\|CDD\|379556	pfam14325, DUF4383, Domain of unknown function (DUF4383). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length.	2.7965e-41
NC_014391.1\|WP_013288012.1\|5503369_5506648_-\|Rne/Rng-family-ribonuclease	gnl\|CDD\|273254	TIGR00757, Ribonuclease_E/G-like_protein, ribonuclease, Rne/Rng family. This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome. [Transcription, Degradation of RNA].	5.88676e-165
NC_014391.1\|WP_013288018.1\|5513586_5515455_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	2.23077e-18
NC_014391.1\|WP_013288017.1\|5511395_5513381_-\|TIGR03960-family-B12-binding-radical-SAM-protein	gnl\|CDD\|188475	TIGR03960, radical_SAM_domain_protein, radical SAM family uncharacterized protein. This model describes a radical SAM protein, or protein region, regularly found paired with or fused to a region described by TIGR03936. PSI-BLAST analysis of TIGR03936 suggests a relationship to the tRNA pseudouridine synthase TruA, suggesting that this system may act in RNA modification. [Unknown function, Enzymes of unknown specificity].	0
NC_014391.1\|WP_013288010.1\|5502486_5502741_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	7.7082e-48
NC_014391.1\|WP_013288021.1\|5519869_5521429_-\|alkaline-phosphatase-D-family-protein	gnl\|CDD\|226070	COG3540, PhoD, Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism].	5.47606e-161
NC_014391.1\|WP_013288023.1\|5522126_5522552_-\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	2.95703e-81
NC_014391.1\|WP_049794893.1\|5524104_5524455_-\|DUF4233-domain-containing-protein	gnl\|CDD\|379420	pfam14017, DUF4233, Protein of unknown function (DUF4233). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.	1.13108e-19

>NC_014391.1|WP_013288014.1|5507827_5509288_-|type-VII-secretion-associated-serine-protease-mycosin
MKVHVGALRPVTAGLLAGLMLLGAAQPAVAAPRRAEQWYLDELRIDRAHQISTGRGVVVGVLDTGVDAGHPDMRGRVLAGGSTRDSGDGRRDPDGHGTHMAGIIAANGTGVVGIAPDARILPIRKPVGAAATKDDSATGIRMAVDGGAKVLNLSYGGAGPVEEVEEAAIRYALERDVVVVAAAGNVRQAGPDVVSPAKIPGVIAVTGTVRGGGFWSGSAQGPEAVIAAPGDEVYNIGPDRGYGWGDGTSDAAAVVSGVAALIRSKHPKLSAPDVINRMIRTARDAGPPGRDPRFGFGRIDPVAALTADVPSVSANPLLGAAAPSASAPPAAAEDDNFDVTKYGDRGGPTDQQVMVIGIGIAVALVVLLALVVFLIWNRRRHRRELAKVGSIPDEALDRMDAGGQGPPVPAGHAAPPPGYGPPGGYPPPGAHPQPGGYPQPGGYPQQGGYPQPGGYPQPGAGAYPPQGQAHTPPGQSPYAPPGDPRP
>NC_014391.1|WP_083395316.1|5506778_5507498_-|DUF2344-domain-containing-protein
MRYAKRGPLRFTSHRDFARAFERALRRAGVPIAFSQGFTPHPKISYASAAPTGVASEAEYLEIGLREPVDPARLREALDAALSPGLDVIDAVEAVGGSLADRIEASYWRIELPEVDPKVLAEAVAAFTAAEEIQVERMTKQGRRTFDARAAVVSIDAMAPAETPSGAAAVPCAILELVVRQVTPSVRPDDVLSGLRAVAALEPPVTPKVIRLAQGTLTAQGEIVDPLEADRDGATIGER
>NC_014391.1|WP_013288012.1|5503369_5506648_-|Rne/Rng-family-ribonuclease
MLENEPEGGERTGAEPAGTTADSATTASGSAASATSAGAGGATTEGTVEGVAETKPPARKRASRRKAAPLNQPEQTDAPVEASTTVTGSGESPQAEVLAPVAGELDTAPKTTRRRRKATPAKAVEEPVAAAGVEAASEEVVPPVKVTRTRRRKATPAAETVAPDETTAAGQAPADGVIDGPVSAPGGDLIAEGRADIDGGETAAPGEAVTAGTAAETAPQAPTGRRRATTSRTKAAGAGKASTGGIGETTGEDVEDAEDAEAEAMADASAAAARTEEVNLARSGGPADATGVVSTGAAVPRAAEEPAETPPATSRRRRAALSAPTVLFMAPQPDEAPAVQVTYPAAEEPIEEAVETGRRRRRGRREVEPVEAEVEPEVAEEELAAEAEETAEGDEDDETAAGRRRRRRGRRGRGRGKGGADEVDDEDVEEPAAAEAEGEAEEPAEDEEAEGEGMTRRRRRRRRRGAGEADTAAEDGVPTVVKIREPRKPVDEVQGVSGSTRLEAKRQRRRDGREQRRTRPPILSESEFLARREAVDRVMVVRQRGDRTQIAVLEDGVLVEHYVTRNSSGTMAGNVYLGKVQNVLPSMEAAFVDIGRGRNAVLYAGEVNWDATGLEGRARSIEQALRSGDSVLVQVTKDPIGHKGARLTSHIALSGRHLVYVPNGNASGISRKLPDTERKRLRDVLKKLVPDGAGVIVRTAAEGASEDELARDVKRLQAQWEDIQAKATEGGAPVLLYEEPDLVIRVVRDLFNEDFRELVIEGEPAYDLVESYLSHVSPDLVARLRRHAGVADVFAEYRIDEQILKGLDRKVFLPSGGSLVIDRTEAMTVVDVNTGKYTGSGGNLEETVTRNNLEAAEEIVRQLRLRDLGGIVVIDFIDMVLESNRELVLRRLTECLGRDRTKHQVTEITSLGLVQMTRKRIGAGLLEAFSETCECCKGRGVIIHTEPVPEKPRGGAGEKVKAVASAVAAPAEEKGRRRGRKAAAEKPAVEAAPEQPSAQPQAVTEATAAPERTVAEVVETDDDYYDTQGYDLSRFETDTPAAPAIADSQEGDSARLAAADDPDAIGDGDNDDDSGAPRRRARRGGARRRTRP
>NC_014391.1|WP_013288011.1|5502752_5503067_-|50S-ribosomal-protein-L21
MYAIVKTGGKQYKVAEGDVIEVEKLAGAPGDAVKLTAVLLVDGDDLVTEAAKLAKVAVSGEIAAHTKGPKIRIHKFKNKTGYHKRQGHRQPLTQVKVTGISSGK
>NC_014391.1|WP_013288010.1|5502486_5502741_-|50S-ribosomal-protein-L27
MAHKKGASSSRNGRDSAAQRLGVKRFGGQVVSAGEILIRQRGTKFHPGDLVGRGGDDTLFALAAGSVQFGTKRGRKTVSIVPQQ
>NC_014391.1|WP_013288009.1|5500944_5502396_-|GTPase-ObgE
MTTFVDRVVLHMQAGDGGHGCVSIHREKFKPFGGPDGGNGGHGGSVSLVVDPQVTTLLDFHFRPHLKAENGKGGAGSNRDGANGRDLVIKVPNGTVVQSLDGEVLADLVGVGTTFEAARGGRGGRGNASLANARRKAPGFAELGEPGDRLDVVLELKSVADVGLVGFPSAGKSSLISVISAAKPKIADYPFTTLVPNLGVVRVDNHTFTVADVPGLIPGAASGKGLGLEFLRHVERCAVLVHVIDTATLEPGRDPLADIDAIESELSQYGGLADRPRLVALNKVDVPDGKDLADIVRPDLEARGLRVFDVSAATREGLRELTYAMAELVDQGRRAAPPAEPTRIVIRPKAVDDAGFTIEAEPDGSYTVRGSRPERWVKQTNFDNDEAVGYLADRLARLGVEEKLAKAGAQAGDLVRIGDREFDWQPTLYAGVDFVPGNRGTDVRLEEKSNRPSASDRLAARKARRVRPEDEVEAAPAAEADAE
>NC_014391.1|WP_013288008.1|5500435_5500885_-|GNAT-family-N-acetyltransferase
MLIESRPSTDPEIAALVVAQQRELRDADGGLDGQVTVVHTDIHYLAAVVGGRAVGCGGLQALDADTGELKRMYVRPAYRGRGIARQLLVALEELAFQQGHRTVCLETGTYLPAAIGLYRSSGYEPIPVYGEYVDNPYSVCFAKRLPVAA
>NC_014391.1|WP_013288007.1|5499772_5500432_+|hypothetical-protein
MPRWLRDNMLSVAMLGAFLVFLLLQSVFGWQVHNEELSRYGAEPLSWWAYLGTGHFAEAVFENWESEFLQMGGYVLLTAYLVQKGSAESKPEDQTDRPEDDRDHARPDSPWPVRAGGLPLVVYRNSLAVALLMIFGGAFLGHLFGGVAAYNQEQALESGAAPISAWQFLGTSDFWFQSMQNWQSEFLAVGVLILLSIVLRQHASPESKPVTAPHAQTSA
>NC_014391.1|WP_041799328.1|5499222_5499687_+|DUF4383-domain-containing-protein
MREHAPARPAVQKVALAAAALFALIGVLGFVPGITTHYGEMTFAGHHSEAKLLGVFQVSVLHNLVHLLFGLVGLVMARRLAGARVFLAVGGALYLVLWLYGFAIDRDTSVNFVPVNDADNWLHLALGFGMLAAGLLLNNNLGTGTRVEAPFDRP
>NC_014391.1|WP_013288005.1|5498228_5499014_-|hypothetical-protein
MTQDLSPSSATYQSTNGGGGVRDQARQVGSDAANAGGAVAQTAKEQGREVVGEAKRQARDLYGETRSQVTAQAGQQQQRAASGLRSLADEMRTMAQQGGGSGPVTELAHQAAERVHGVAGWLEQREPGDLLNEVKTYARRNPGTFLVGAALLGVVAGRLTRNIAAIGDDSTARPAYDPDRTAVIPTAREVPDQVPPGGYLDPTPGSYAEPDPGYSAPGATYPAGGAPNTWADPAGGTGQPLPPPERTDPLPGVPSTGAPRP
>NC_014391.1|WP_013288016.1|5510787_5511225_-|hypothetical-protein
MGINPPDTGDLHVSVEDLDAAAEYIERLKQYVEDTISWEMERIKERMKGDSGNAQTVPNGTPFGAYEDARMQWQALTTSTASMEAHLKAISMKLAGLKQGTQDIAKAFRDAEARNAANGKDIERLLESAAPPPDAGQQPTYPYTA
>NC_014391.1|WP_013288017.1|5511395_5513381_-|TIGR03960-family-B12-binding-radical-SAM-protein
MSAPSTTPRPAAANSVWPRLEPLLPQVTKPIQYVGGELGAVVKDWDAATVRWALMYPDAYEVGLPNQGVQILYEVLNELPDVLAERTYAVWPDLEKLMRAHGVPQFTVDAHRPVRDFDVFGVSFSTELGYTNLLTAIDLAGIPLLAADRTDADPVIVAGGHAAFNPEPIADFVDAAVLGDGEEAVLEITAIVREWKTEGSPGGRDELLLRLARTESVYVPRFYDVDYLPDGRIQRVVPNRPDVPFRVHKRTTMDLDAWPYPKKPLVPLAETVHERYAVEIFRGCTRGCRFCQAGMITRPVRERSITTVGQMVKEGLEFSGFHEVGLLSLSSADHSEIGDMCSGLAEQYAGTNVSLSLPSTRVDAFNIDLAQELSRNGRRTGLTFAPEGGSERIRKVINKMVSKEDLIRTVVTAYSNGWRQVKLYFMCGLPTETDEDVLEIADMAHEVIRAGRAATGSKDIRCTVSIGGFVPKPHTPFQWASMERPEVIDGRLKLLKQAINSDRSLGRAIGFRYHDGEPSLIEGLLSRGDRRVGAVIRKVWENGGRFDGWSEHFSYQRWVDAATEVLPAYGVDLDWYTTRQREELEVLPWDHLDSGLDKDWLWQDWQDSLSEYEQDDCRWTPCFDCGVCPSMDTEIQIGPTGRKLLPLTPVNGLKLPAAAQG
>NC_014391.1|WP_013288018.1|5513586_5515455_+|hypothetical-protein
MPQPQPGADRPADGAEMPSVTEPATAADTEDATGASAPASPSGTPEAADDRTPGATAADQPSGAADSEPSEQSEQAGPARLDEPAEQALRDDRPEPSEQAEPARRDQAAEPADPASTAPLDSASPHPPADDAAAPTGRAGPQASATTADAFSGNAGMPADAPTGDEAPTADAGTPGGTPPVPVTRARGSAAVPGRTTPVPTPRTGRQPDPTRIDVAPQPPRAAATPDPTKVENAQDRMPSANTPDPTRVENTPDPTRVDAPAPRWSGSAAVPPPPPRRPAWGESAEPTPVPPLASPEHATPVDPWAGVDTTGWELHAPELPPPTPTLPYTAPWAAPDNPHPAHPAPPAAHPAPQPAPPARPAPPAARPVSPPPHSPPYPGPARPVSPPHHPGPPAARPLPPAAPVAPPAKPGRPPKQRRGKAGPPVAPPPGWQQPPKRTRRRRRWPWVLLLSVACCCGLPLWWFQPISSQYPASATLPDQIDSMRLRQDESSRTAAEELKSQVREANLLAEDTFAGIYSTSDGKRVTLFGSTGLRFSPESDAKAELDRLAGDYALKESVAVDTGVRGRHERCAVGRADGDSVVVCVSADHGSLTTGVFTRLSVDDSGRLLNDLRQRVVVPKS
>NC_014391.1|WP_013288019.1|5515459_5516167_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MPLLYTIGKLTVAPALRLAFRPHVEGLEHIPATGGAIFASNHLSVADELLLGTVVPRHLAFWAKSEYFKGTGLKGGFSKFVLTGLGAIPVERAGGRAALTAFDAAIPVLKAGDLVAVYPEGTRSPDGRLYRGRTGTVRLAIAAGVPIIPVGVTGTDKAQPIGTRIPRPGRAKITIKFGKPLDFTGRPDDRTSLRAMTDEMMAEIQKLSGQEYVPRYAPKRADQTAGDQAGGEQTA
>NC_014391.1|WP_013288020.1|5516324_5519471_-|isoleucine--tRNA-ligase
MAYPLHDPTGAGVPASPDLPAVERRVLEHWTADKTFEASVEARDAGRDGENEYVFYDGPPFANGLPHYGHLFTGYVKDVVPRYQTMRGRHVERRFGWDCHGLPAEVVAEKQLGITTKAEILDLGVARFNDACRTSVLEFTHDWERYVTRQARWVDFANDYKTLDLDYMESVMWAFKTLHDKGLVYEGFRVLAYCWRCETPLSNTETRMDDVYRDRHDPTLTVWFELTADENAPEPLRGPVKLGVWTTTPWTLPSNLALAVGPDIEYALLERDGERYVVGAARLGAYAKELEGYEQVGTVYGRDLVGRRYTPLYDFLVEPAGPNAYQVLGADFVTTEDGTGIVHLAPAFGEDDQNTCNAAGIPTVVTVDDHTRFTALVPPYQGEQVFDVNKPVIRELKERGVVLRQDTYTHSYPHCWRCDTPLVYKAVSSWFVAVSTFKDRMVELNQQINWTPGHIKDGSFGKWLANARDWSISRNRFWGSPIPVWKSDDPNHPRVDVYGSLEQIERDFGVRLTDLHRPAVDDLVRPNPDDPTGKSMMRRVPEVLDCWFESGSMPFAQVHYPFENREWFEHHYPGDFIVEYIGQTRGWFYTMHVLATALFDRPAFRNCLSHGILLGSDGRKMSKSLRNYPDVYHVFDSYGSDAMRWMLMSSPVLRGGDMAVTESGIRDAVRQVLLPLWNVWYFFSLYANADGHTARRRTDSTNVLDRYVLAKTNELVATVGAQMDAYDISGACATVRSYLDALTNWYVRRSRDRFWAGDADAFDTLWTVLETLCRVVAPLAPLTAEEIWRGLTGERSVHLTDWPQAEEFPADHELVSAMDNVRAVASAALSLRKAKGLRVRLPLAKLTVASPVAAQLRPFADLVADEVNVKEVVLTDEVSAYCQQVLTVVPRALGPRVGKAVQQVIKAVKAGEWELRDGAPVAAGVTLAEGEYELRLVAADAEHSAPLPGGEGVVVLDTEVTPELAAEGLARDVVRVVQQARREADLDVSDRITVAVSASEEVRAAVAAYTGFVAREVLADSIDFAEGLDGFDGEAGEGERVTVTVRKV
>NC_014391.1|WP_013288021.1|5519869_5521429_-|alkaline-phosphatase-D-family-protein
MTHFDRRTLLRAGLVAGAGVAGGALLGAPGAPAAPGLRRSGRPLLTHGVQSGDVTADSALVWTRADRPGRMLVEVSRRPDLRGARLVRGPVVDPTGDLTGKVRLRGLPAGERLHYRVRVESLDRHGLCSEPLTGSFATAPGRHQRRDVRFVWTGDIVGQGWGISTDFDGLAIFRAMRERRPDFFLCSGDTVYADGPLAESVVLPDGRTWRNLVTPEKSKVAETLAEYRGQFAYNLLDEHLRAFAAQVPQINQWDDHEVVNNWYPGEILTDERYGEKRVDVLAARARQAFHEWLPVPSGGPMYRKLSYGPLLDVFVLDMRTYKDPNDGNTYADRNRGLLGKAQREWLIRELRASRATWKVIANDLPIGLVVPDGAGSQEGVAQGDHGAPAGRELEFAEVLRASHRAGVTGLVFLTADVHYTAAHHYDPARAAVRDFSPFWEFVSGPAHAGAFGPNALDGTFGPKAVFVHAPPRANTSPAEGFQHFGEVTIDGPSAALTVHLRDRTGASLWTTTLPAPTSR
>NC_014391.1|WP_013288022.1|5521624_5522065_+|carboxymuconolactone-decarboxylase-family-protein
MSRMDMAAVAPEAYQAVLGLEKYVRANVDHTVLELVKLRASMRNGCAFCVDMHSREALAAGEDSRRLFAVAAWREAPFFDERERAALALTDAVTRLGEHGVPDDVWDAAAKVWSEKELADLVMAIATINVWNRVAVTCRTQPPAQV
>NC_014391.1|WP_013288023.1|5522126_5522552_-|nucleoside-diphosphate-kinase
MSSSSPDERSLVLIKPDAVRRGLVGEILSRFERKGLRIDAMVSRTMDGDFADQHYAEHVDKPFYPPLKTFMTSGPLVALVLSGDQVVEVVRAMIGSTDGRKAAAGTIRGDLSLSNRENLVHASDSADSAKREIALWFPELA
>NC_014391.1|WP_013288024.1|5522697_5524032_+|VOC-family-protein
MANGGNRTIAPVRKLIGAVLGTVATFVTVFGLGMTSWAIVALGVALLVLAIALATVRGGGRTWVIGLGHVHSASEPPTQYAFGRCELQLVIDAPGLPPRSKKIIEPRVPVAKWPSLGQALPVRVALDDQRHVRVLWDEVPTHAESAAAVADLPPEYAAEPDPLDEPLIAQEAPPWAGRAPEDDFRDDYPPAPDPYLDDVPPRAEEREPVVLHQSPGGPVVLEGQLVERAERAAGSGPLPRRAPAPRSPAEEPVDTVPVETVFVDSEPADSGRSDTVPDPIDVPLDDPSDAPRRSDAPPTAEELDEAIFGPSGAAEPDELASPISGVGITLLVTDLDRSLDFYRELGFDELDRGEGNAVLSSGPTRLVLRRVTGAAPISRRLVHVNLEVDDIQGAYERLRDSGVRFTYAPRVVNRGTKLEVWAAAFRDPDGHGVALTQWRTLAQV
>NC_014391.1|WP_049794893.1|5524104_5524455_-|DUF4233-domain-containing-protein
MGGVRRSGLRNPDKAVRGLGAGTMSLEALVLLLAIQPIRVVGGDLSGAAIGAIVALAVACVVLAGMMRRPWAWYAGTVIQGLLLLSGLLHWSLFALGVMFALVWAYALHVRRVILG

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Crispr_ID: NC_014391_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014391_8

6596285-6596468

Orphan

Consensus_repeat	Method
GTGGACGCCGACACGCTGGAGACGCTCGACCCGCGGGCGGTACGGC	PILER-CR

2 spacers

The CRISPR arrays of NC_014391_8

>merge|NC_014391|8|6596285-6596468|PILER-CR
GTGGACGCCGACACGCTGGAGGCGATCGACCCGCGCGCGGTACGGAACCTGCGCACGCCGGCGGGCCAGCCGATCGACGCGGACACGCTGGAGACGCTCGACCCGCGGGTGGTACGCGGCATGCGGGCGACGACAGCGGTGGACGCCGACACGCTGGAGACGCTCGACCCGCGGTCGGTCCGGC

>NC_014391|8|1|6596285-6596468|PILER-CR
GTGGACGCCGACACGCTGGAGGCGATCGACCCGCGCGCGGTACGGAACCTGCGC	ACGCCGGCGGGCCAGCCG
ATCGACGCGGACACGCTGGAGACGCTCGACCCGCGGGTGGTACGCGGCATGCGG	GCGACGACAGCGGTGGACGCC
GACACGCTGGAGACGCTCGACCCGCGGTCGGTCCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014391.1\|WP_013289012.1\|6590790_6592806_+\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|227111
NC_014391.1\|WP_013289018.1\|6598589_6602171_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|143636
NC_014391.1\|WP_013289013.1\|6592802_6593966_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173838
NC_014391.1\|WP_013289017.1\|6597995_6598454_-\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013289010.1\|6587978_6589118_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173849
NC_014391.1\|WP_013289009.1\|6586305_6587982_+\|DUF1446-domain-containing-protein	unknown	unknown	gnl\|CDD\|377804
NC_014391.1\|WP_013289014.1\|6594024_6595803_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|312032
NC_014391.1\|WP_030273791.1\|6606215_6607364_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223082
NC_014391.1\|WP_013289019.1\|6602167_6602950_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293836
NC_014391.1\|WP_013289007.1\|6584870_6585482_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_014391.1\|WP_013289022.1\|6603782_6604223_-\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013289021.1\|6603564_6603720_-\|DUF4177-domain-containing-protein	unknown	unknown	gnl\|CDD\|379366
NC_014391.1\|WP_013289008.1\|6585514_6586309_+\|TIGR03084-family-protein	unknown	unknown	gnl\|CDD\|274423
NC_014391.1\|WP_013289024.1\|6605186_6606161_+\|ArsA-family-ATPase	unknown	unknown	gnl\|CDD\|223082
NC_014391.1\|WP_013289011.1\|6589114_6590722_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit	unknown	unknown	gnl\|CDD\|178415
NC_014391.1\|WP_013289020.1\|6603097_6603559_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100006
NC_014391.1\|WP_013289006.1\|6584020_6584764_+\|metallophosphoesterase-family-protein	unknown	unknown	gnl\|CDD\|378975
NC_014391.1\|WP_013289016.1\|6596489_6597965_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_014391.1\|WP_013289023.1\|6604558_6605137_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227505
NC_014391.1\|WP_007466162.1\|6583114_6583792_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736

Protein	Function_ID	Function_description	E-value
NC_014391.1\|WP_013289012.1\|6590790_6592806_+\|biotin/lipoyl-binding-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NC_014391.1\|WP_013289018.1\|6598589_6602171_-\|AAA-family-ATPase	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	1.04186e-51
NC_014391.1\|WP_013289013.1\|6592802_6593966_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	6.049e-84
NC_014391.1\|WP_013289024.1\|6605186_6606161_+\|ArsA-family-ATPase	gnl\|CDD\|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	7.72761e-34
NC_014391.1\|WP_013289010.1\|6587978_6589118_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	5.58972e-137
NC_014391.1\|WP_013289009.1\|6586305_6587982_+\|DUF1446-domain-containing-protein	gnl\|CDD\|377804	pfam07287, AtuA, Acyclic terpene utilisation family protein AtuA. This family consists of several bacterial and plant proteins of around 400 residues in length. One member of this family has been characterized in Pseudomonas citronellolis as AtuA, a member of a gene cluster that is essential for the acyclic terpene utilisation (Atu) pathway.	1.7087e-174
NC_014391.1\|WP_013289014.1\|6594024_6595803_-\|alpha/beta-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	1.55831e-19
NC_014391.1\|WP_030273791.1\|6606215_6607364_+\|AAA-family-ATPase	gnl\|CDD\|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	4.09799e-46
NC_014391.1\|WP_013289019.1\|6602167_6602950_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293836	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	8.36675e-67
NC_014391.1\|WP_013289007.1\|6584870_6585482_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.45631e-08
NC_014391.1\|WP_013289021.1\|6603564_6603720_-\|DUF4177-domain-containing-protein	gnl\|CDD\|379366	pfam13783, DUF4177, Domain of unknown function (DUF4177).	0.000878703
NC_014391.1\|WP_013289008.1\|6585514_6586309_+\|TIGR03084-family-protein	gnl\|CDD\|274423	TIGR03084, conserved_hypothetical_protein, TIGR03084 family protein. This family, like pfam07398, belongs to the larger set of probable enzymes modeled by TIGRFAMs family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized. [Hypothetical proteins, Conserved].	6.95349e-112
NC_014391.1\|WP_013289011.1\|6589114_6590722_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit	gnl\|CDD\|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
NC_014391.1\|WP_013289020.1\|6603097_6603559_-\|RidA-family-protein	gnl\|CDD\|100006	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	1.45189e-66
NC_014391.1\|WP_013289006.1\|6584020_6584764_+\|metallophosphoesterase-family-protein	gnl\|CDD\|378975	pfam12850, Metallophos_2, Calcineurin-like phosphoesterase superfamily domain. Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	7.54698e-16
NC_014391.1\|WP_013289016.1\|6596489_6597965_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.06807e-63
NC_014391.1\|WP_013289023.1\|6604558_6605137_+\|hypothetical-protein	gnl\|CDD\|227505	COG5178, PRP8, U5 snRNP spliceosome subunit [RNA processing and modification].	4.68194e-06
NC_014391.1\|WP_007466162.1\|6583114_6583792_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.7062e-55

>NC_014391.1|WP_013289014.1|6594024_6595803_-|alpha/beta-hydrolase
MPRAIRSLAATGIAGVLLAGPAVAPAAAATPQPPAHDRTTAAEARRVDRVPTPKLDWYACYDYAECATVRLPLDYDNPKGATTEVALLRVKARDQQRKVGSLFLNPGGPGGSGTSIALAAPYFLGDDLLDRFDIVGVDPRGVEASENIKCFRSVKDQTRAYAGLNVAFPWTKAEEKAYVAASKAVGKACSTTGKPLTGAASTAEVARDMDVLRRAVGDKLLSYLGFSYGTALGQYYANMFPDRFRALVVDGVLDPNAWIGQGSARNQLQETRLRSADGAYRALREILARCGEAGAEQCALASTGNPLAAYDTVAKRLRKKPVVIEDPDFGSFTVSYADFVGATLGALYDPYGWQSVVDLTVQLLALTDPAAGKAATATARKALAARAAQARQQRGYDFPYDNGLETFLTVDCTDAYHPKSADAWPALSAKEDKRAPYFGRAWAWGTSPCARNTWTVRDEDAWTGPFNRVTAAPVLVVGNYWDPATNYQGAVSSAKLLPNSRLLSSDSWGHTAYGTSACVTGRIDAYLLTGKLPAKGTLCVGDAQPFQEDAAAGRADASKSALARAGEPSRGEPKRLPPVATPRPAVGTLTVR
>NC_014391.1|WP_013289013.1|6592802_6593966_+|acyl-CoA-dehydrogenase
MNFDLTPEQDQLRDAVRALGRKYGHSYFVEKARSGEHTTELWHEAGRLGYLGVNIPTEYGGGGGGITELALVCEELAATGCPLLLLVVSPAIAATIINKHGTEEQRKKHLPGLADGSQKIVFAITEPDAGSNFHRLATVARRDGDDWLLSGRKIYISGVDEAGHVLVVARTEDASTGKLKPALFIVPTDAPGLEKSKLDMEILSPENQFLLFLDDVRLPADALVGESLDAGLPALFAGLNPERITVAAMGAGTGRYAIERASDYTATRKVWGGRSIGSHQGVSHPLAHAAVQVELARLMIHKAATLYDAGRDLEAGISGNMAKYAAGEAAALAVDTAVQALGGAGMTTEYGVATLLGAVRAGRIAPVSREMILNFVAQHVLGQDKSY
>NC_014391.1|WP_013289012.1|6590790_6592806_+|biotin/lipoyl-binding-protein
MINKLLVANRGEIARRVFATCRALGVATVAVHSDADADAPFVADADQAVRLPGNTPAETYLRIDAILDAARRSGADAVHPGYGFLAENAEFAAAVTDAGLTWVGPSAKAIAAMGDKMAAKAMLADAGVPMLPTWTDPAEVTAFPVLVKAAAGGGGRGMRIVRDAAGLAEAVAGARREAAAAFGDGTVFIERYVERGRHVEVQIFGDTHGTVVALGVRDCSIQRRHQKIVEEAPGVLPDDVRAELHEAAVAAGRAVDYVGAGTVEFLLAPDGQVHFLEMNTRLQVEHPVTELTTGLDLVRLQLLVAEGEPLPVTTTPPADGHAIEVRLCAEDPAQGFRPATGTLHRFAIPGVAAEFGPARGLRLDSGVVDGSTVSVHYDSMLAKLVAWAPTRTEAARALAGALAHAELHGVATNRDLLVRVLRSAEFTAVDLDTGFLDRHPEVFAPLLPAEQLPVAALAAALSGAAERRAAAPVLAGLPSGWRNVPSFPQVTRFTVGDGEEIEVHYRLDRTGALAEWGRKGPLLTDPVEEGSSVNTELPVVELVTATPGRVVLDVDGVRRAFRVHRAGSSVFVDGPDGAASLTELPRLPLPTAELAAGSLLAPLPGAVTRVHVEVGQRVAAGDLLLTLEAMKLEHPVLAPADGVVTELPVPAGGQVETGAVLAVVDPEEDPQ
>NC_014391.1|WP_013289011.1|6589114_6590722_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit
MSTTVLQSTIDPSAPAFTANREALLERLAELEEALDQARGGGGEKYVTRHRGRGKLLPRERIELLLDPDSPFLELSSVAAFGTDFPVGASTVTGIGVVEGVECLIVANDPTVRGGAINPWSLAKTRRAGEIAAANRLPMVNLVESAGADLPTQAEIFIPGGRVFRDLTRLSAQRIPTVSVVFGNATAGGAYVPGMSDYTVMIRDRSQVYLAGPPLVKMATGEVTDDESLGGAAMHATTSGLADFLAEDERDGIRLARQCVRRLNWRKHGPPPRNPHPLPPRYDPEELLGIASADLKVPFDPREVLARVLDDSAFDEFKPGYGTALVTGWGELHGYPVGVLANARGVLFSQEAQKAAQFIQLANAADTPLVFLQNTTGYMVGTEYEQRGIIKHGALMINAVSNSKVPHLTVNLGASYGAGNYGMCGRAYEPRFLFTWPNAKSAVMGPAQLAGVLSIVARQAAAARGREYDEDTDAAMRMMVEQQIESQSGALFLSGRLYDDGVIDPRDTRTVLGLCLSAIHNGPVKGADGFGVFRM
>NC_014391.1|WP_013289010.1|6587978_6589118_+|acyl-CoA-dehydrogenase-family-protein
MTIVDTPERRQLRELTRSFVTREVLPHLSDWERAGEVPRSLHETAAKIGLLGIGFPESVGGSGGDLLDSMVVTEEIIRSGGSSGLVAALFTHGIALPHMVETQDEGLIDKYVRPALAGTMIGALAITEPDGGSDVAGIRTCAVRDGDHYVVNGSKTYITSGVRADFVTTAVCTEFPGSGSVSLLVIDKGTPGFTVGRRLEKLGWHCSDTAELSFVDVRVPVTNRVGPEDTGFLAIMQQFANERLSLATQAYATAQRCVDLAVQWCRDRQTFGRPLVGRQVVRHKLAEMHSRTDAARAYVHDVAERVAAGQPVVTEVAMAKNVAVATCDWVVDAALQLHGGFGYMRDAEVERHYRDARLLGIGGGTTEIMNEIIAKGMGL
>NC_014391.1|WP_013289009.1|6586305_6587982_+|DUF1446-domain-containing-protein
MSVLRIGNASGFYGDRFAAWREMLDGGELDVLTGDYLAELTMLILGRDRMRDPSLGYAKTFLRQAEGVLGTALERGVTLVTNAGGLNPAGLADAIRSLGDRLGLQVRVGYVEGDAIQRPDALTANAYLGAFGIAACLDAGADVVVTGRVTDASLAVGPAIARFGWTRDDLDALAGATVAGHLIECGAQVTGGNFSFFTELPDGGHRPGFPIAELHADGSSVLTKHAGTGGAVTVETVTAQLLYEVGGPDYLGPDVVTRLDTVRLEQEGPDRVRVSGVRGTPPPDTLKVGVNNLGGFRNSMTFVLCGLDIPAKAALVRGQIEESVGTEGLEFTLARTDHPDTGDTEAASALLHVHLRDGDKSRAGRAFSAAAVELALASYPGCTLTTLPGDATPYGVFTADTIAQDAVEHVAVLPSGERVAIAPPTVTGGLQGAPVQHEALRGGPSLPGTRRGPLGELVGARSGDKGGDANLGVWARTDATWPWLRDWLTVERLAELLPETASLTVERYELPNLRAVNFVIRGLLGQGVAASTRFDPQAKALGELLRSRVVDLPTEARA
>NC_014391.1|WP_013289008.1|6585514_6586309_+|TIGR03084-family-protein
MVDLTALLADLAAESEQLDALVADLPPEGWERPTPAPGWTVAHQVAHLAWTDHVAYLAATDESAFFASVMAAPDPSRLVEDGAESFLAPPPALLARWRAGRSALAGALAAVPAGQKIPWYGTSMSPTSMVTARLMETWAHGEDVADALSVSRTPTARLRHIAHLGFRTLGHGFSAHGRDVPTAPVRVELTAPADGEVWEFGPADATDRVTGPALDFCLLVTQRRHRADLALTATGPVADEWLDVAQAFAGPPGGKREPANGTSS
>NC_014391.1|WP_013289007.1|6584870_6585482_+|TetR/AcrR-family-transcriptional-regulator
MSSRVPQQERSRATQARLLEATVECLVEHGWSGTTTTVVAAHAGVSRGAQLHHYPTKAALVTAAVTHLTERRAAELRAEAAHLPVGPKRLDGVVDLLAASFTGPLFVAALELWVAARTDAELRAALVPLEARIGREMHRLTVELLGVDERKPGVRESVQATLDLLRGLGVANLLSDDSPRRAALLHTWKRQLAALLTPESERH
>NC_014391.1|WP_013289006.1|6584020_6584764_+|metallophosphoesterase-family-protein
MPDRVAVLSDIHGVLPALEAVLAEPDVAAADLIVLTGDLAAGPQPVEVLDRLAALGDRACWVGGNADRELVQARAGRSSPIAVSNWAAGQLRDDQVARLAALPPSVTLPVTGLGDVLFCHATPRDDEEVVLVDSRLDRWAEVFAGLPAEVGTVVCGHTHMPFTRLADRRLVVNPGSVGMPYGGAGAWWALLGPGVQLRRTRFDVDAACTRVAAESTFPDAAAWADEYVRSRHSDADALTVFAPRDGR
>NC_014391.1|WP_007466162.1|6583114_6583792_+|Crp/Fnr-family-transcriptional-regulator
MDEVLARSGIFQGVDPEAAEALAKEMETIEVRKGEIVFNEGEPGDSLYILLSGKIKVGRRAADGRQNLIAVMGPSDMVGELSLFDPGPRTATATAVTDTRLVRLRKQALRPWLNNRPEIAEQLLRVLARRLRRTNDSLADLIFTDVPGRVAKNLLQMAGRFGTRDGGVLRVTHDLTQEEIAQLVGASRETVNKALADFASRGWLRLDGKSIIILDPERLARRARV
>NC_014391.1|WP_013289016.1|6596489_6597965_-|serine/threonine-protein-kinase
MTETPPGALRLPIVPGLTDLQVFARGGYATIYRATQISVGREVAVKIENRTLDSERDQARFLREARAAGRMSSHPHVVDLFDVGVTVDQHPYLIMELCDGSYAERMRTSPLGPAETRDLGVKIADALAHSHAAGVLHRDVKPANILHSEFNSAVLADFGLAVLAEFRDSSVMLEALTPAYAPPETFNHSPPTPAVDVYSLCATLYAVMYGRPPRWHSERNPSLVTVLEMFQQPIPGLPGVPGELIDVLRLGMSNDPGARPSAVELRGLLASLPLDGAPATGGLYDGATGDRFHRTGGPNPRPPADDDHPTVASRGRRWPKRWFLGGAGVLALAASAGGGWVAGGHTPAVTPTPATSGVAGVAPVPGCASADVRLPAGARCATELECFGPVRLRRDRAEASRVPCDGQHTWETYAAGDLPAGLAGARHETVAADPAVGRVCNADTFRLVSGGKSASGWNLEVLPPEAEADRTYRCLAGRGVNALAGPTLTGR
>NC_014391.1|WP_013289017.1|6597995_6598454_-|hypothetical-protein
MRLPRSGAGWTIAVFGLLALLLGALGLIWPETQLRLLGFEVPAERAPGDYTGTFLTASSMASFNMGVYYLLAVATEWRPFYRFTVWFRLVTFTVFTIAVLSDVAPDRFFAVAAWEGLGAVATAVGLWWDARRAAAATDDSVPGPVPATDTAR
>NC_014391.1|WP_013289018.1|6598589_6602171_-|AAA-family-ATPase
MTCPVCGTVAVPGARFCHNCGAALPAAATLPAAERRVVTVLFGDLSDFTSWSEDLDPERVGAVTDRVLAALAGAVKTFGGHVDKLTGDGIMAVFGAPVAHEDDAERAVRAALSMQRAVRRVLDDERGGGAPLGLRVGLNTGDVIAGIQAAIEYTVIGDTVNTAARLADAAAVGAVYAGARTSAATRHVASWRALRPLRLKGKREPVEAYELLGLLDAPGTRSGLGDEAPFVGRETEIGRIAGRLAEVIDRGEPRVLLMTAEAGIGKSRFAAEVERLAAGYDVGAGRYAAHTGARVLSVRCAAFGERRRLAPLADLVRAAVGLPGDAATAVTRPAVEERLRRLGQRLSRLPGDPPPIAVDQLLALLGYAELPPATENGEWNAAGPPPDDEAVPTAVADLLSALAGEAPLVIVVDDLHDATAETLKALALTLNRLSGPVLVLLLGRPELVRTAGALTRVADAEVHALPPLRGADASRLLTSYLSGGRMPQTDADRLLATAQGNPFYLAELVTLLMERGALTAGPGRGADVGWRLAPGSLGSRLLSRDLAAVLAARIDALPPNARSALRDAAVVGDTVPAGALEALREQRVGRDGRPAAVAAVELDRAVEELLQRRMLHRTRSGFAFATPLMREAAYAGVSKAELAERHAALARWAAPESVDETGGAPGGAFTEAARDDFVAEHVERATALADAVKLRPDAPARAVTPLGVAALGRAARRSLRSGEPALAVEYAERAAELARDGVPPADRVVHARALLQIGRPADALAFAEKIAANTGDPATRTAALLLAGQAQQTLGDAERAECNWQEALQVATDAGLPTLRASAMRRLGMADFIAGRLGQASSRLAASYQVSLAARDPRGQAWSLQNLAWVTTTRGDFAGTDAVLGRAARLFAELKDPYGRAWLRGTTAFARLLAGRLREACRMARVFLPFGERVGEAWAVGTLRAVEAYATAELGDLAEADRAARRAYRDFAEVGDDWGQGFALVVRGVVARGLGEPEHAADLFTEALEYADRTTHPLLTGMAGTLRGFVALDMGDHETAEREARSVLTRVEPHNPQAPAQVAPRVLLAMARLAAGDPGTAVGLLAPVATGAANAPSLLFSRRQTMARYAAALLAHGQREQALDWAQRSITAPAEDVRSQVVALLVLAEALDACGRRAEALTNAEEAVRLAYATEQRSERIVADALRVRLSGG
>NC_014391.1|WP_013289019.1|6602167_6602950_-|MBL-fold-metallo-hydrolase
MAGAAGALAEELPAWVTLLRAPNPGPMTLDGTNTWVLRAGPDAPAVVVDPGPADEGHLAAIAAQGRIGCVLITHGHADHTEGAPRLRELLDGVPVLAADPAHTAGGEPLSADTALDVGLDLRLLPTPGHTADSVCLVAAHGGERVVLTGDTILGRGTTVVAHPDGHLGDYLSSLELLSTYREIPALPGHGPALADCGVAADFYLAHRRARLDQVRAAVAAGATTAAEVVAVVYADVDRSLWWAAEWSVRAQLEHLGVEQP
>NC_014391.1|WP_013289020.1|6603097_6603559_-|RidA-family-protein
MSNGPQAKLAELGLELPEVVPPVASYVPAVQSGQHVYVSGQLPMAEGKLLATGKVGNGVSAEQAKDLAQRCALNALAAIDALVGLENVVKVVKLTGFVASAPGFTGQPGVINGASDLFGAVFGEAGRHARSAVGVAELPLDAPVEVEVIVEVA
>NC_014391.1|WP_013289021.1|6603564_6603720_-|DUF4177-domain-containing-protein
MQKWEYATVPLLVHATKQILDNWGEDGWELVSVVPGPNPEQLVAYLKRPKG
>NC_014391.1|WP_013289022.1|6603782_6604223_-|hypothetical-protein
MRDAENSPRGQFPGDRAGRPGEAEGPGAPFNERSYGPPADVVRTLPRSGGRGRDEDEPGYVIHLQVRVPDLAAATALAGTVATSLGFLMELDAGETTVSTADDQNNRHRVFCDLLLPDRSRCPQRFEHEGPCGEPPAAPEPRPASW
>NC_014391.1|WP_013289023.1|6604558_6605137_+|hypothetical-protein
MTQPPVGGDTGTPGDPNPQPPPTGGAPPGSAPPAGPPAYPSEPQPRKRPAVLIVSLVLAAAVLLCGGGGTAAFLALRNSEDGQGAKEPQVAVDGFLKAVYQERDAEKAAAFVCSAARDDEKITTKVAEVQKYVAQYQNPRFRWPTPTVDNQTGDRATVSARVTMTTADEKVAEQALRFTVVRKTGWWVCEVG
>NC_014391.1|WP_013289024.1|6605186_6606161_+|ArsA-family-ATPase
MAASEQPAEPAGRWPARLHVVTGKGGTGKTSVAAALALGLAAGGRRTLLVEVEGRQGIAQLFGTDPLPYEERHLADAPGGGEVRALAVDAEEALLEYLDMFYKLGAAGRALRKLGAIDFATTIAPGLRDVLLTGKVKEATTRTSGSRRTYDAVVLDAPPTGRIGRFLNVTAETARLAKVGPIKTQSEGVSALLRSPMTAVHVVTLLEEMPVQETLDAVAELTQLGFPVGRVIVNGVRPPVPAGRAVTAAELKRGLAAAGLPTDGPTVAGLVEEARDQQVRRELEDSLRGDLVDLGLPLVELPLLPEGVDRAGLETLAEALVRAD
>NC_014391.1|WP_030273791.1|6606215_6607364_+|AAA-family-ATPase
MVPSEDAAPPLDVDQILADDGVRIVVCCGAGGVGKTTTAAALALRAAERHGRRTVVLTIDPARRLAQSLGLTELDNTPRQVKGIDVEASGGELHAMMLDMKRTFDDVVLQHTDPAKAAEIFANPFYQAMSSTFAGTQEYMAMEKLGQLHARGEWDLIVVDTPPSRSALDFLDAPARLSRFLDGRMLRLLLAPARSGGRSMFSLVTASFGMFSKVVQKVIGAQLLTDLSGFVAALDSMFGGFRQRAEQTYRILQARETAFLLVAAPEPDAVREAAYFAGRLRSERMPLAGLVLNRVHRPASDLSAAESLAAAERLAGVGGHEGTVEVLRAHAALAQQAVREEQVAARFTEAFPAVPAVSVTAQPADVHDVDGLRTIGEAISRS

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Crispr_ID: NC_014391_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014391_9

7022363-7022456

Orphan

Consensus_repeat	Method
CCGCCTGCTCGCCGGAGAAGGCGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014391_9

>merge|NC_014391|9|7022363-7022456|CRISPRCasFinder
CCGCCTGCTCGCCGGAGAAGGCGGGTGTCACGTCCACCGCCGGGTCGGCGGGCTCGATCCCGGTCACCACCGCCGGCTCGCCGGAGAAGGCGGG

>NC_014391|9|7|7022363-7022456|CRISPRCasFinder
CCGCCTGCTCGCCGGAGAAGGCGGG	TGTCACGTCCACCGCCGGGTCGGCGGGCTCGATCCCGGTCACCA
CCGCCGGCTCGCCGGAGAAGGCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014391.1\|WP_030269559.1\|7024710_7025124_-\|ribonuclease-P-protein-component	unknown	unknown	gnl\|CDD\|376392
NC_014391.1\|WP_013477538.1\|7024429_7024669_-\|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl\|CDD\|376620
NC_014391.1\|WP_013289380.1\|7016091_7016955_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_014391.1\|WP_013289388.1\|7025158_7025296_-\|50S-ribosomal-protein-L34	unknown	unknown	gnl\|CDD\|366117
NC_014391.1\|WP_013477529.1\|7011655_7012816_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NC_014391.1\|WP_013289375.1\|7011169_7011493_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NC_014391.1\|WP_174361833.1\|7021532_7022246_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NC_014391.1\|WP_013289378.1\|7013772_7015086_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_014391.1\|WP_013289386.1\|7023427_7024429_-\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|234941
NC_014391.1\|WP_013289385.1\|7022626_7023217_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|224760
NC_014391.1\|WP_041784681.1\|7010177_7011131_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_014391.1\|WP_013289377.1\|7012824_7013490_-\|hypothetical-protein	unknown	unknown	unknown
NC_014391.1\|WP_013289379.1\|7015093_7016089_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234948
NC_014391.1\|WP_128136872.1\|7019949_7020756_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113
NC_014391.1\|WP_013289382.1\|7018881_7019922_-\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|275105

Protein	Function_ID	Function_description	E-value
NC_014391.1\|WP_030269559.1\|7024710_7025124_-\|ribonuclease-P-protein-component	gnl\|CDD\|376392	pfam00825, Ribonuclease_P, Ribonuclease P.	2.80434e-20
NC_014391.1\|WP_013477538.1\|7024429_7024669_-\|membrane-protein-insertion-efficiency-factor-YidD	gnl\|CDD\|376620	pfam01809, Haemolytic, Haemolytic domain. This domain has haemolytic activity. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	3.11385e-37
NC_014391.1\|WP_013289380.1\|7016091_7016955_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.000161049
NC_014391.1\|WP_013477529.1\|7011655_7012816_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	2.90101e-58
NC_014391.1\|WP_013289375.1\|7011169_7011493_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	2.44109e-46
NC_014391.1\|WP_174361833.1\|7021532_7022246_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	2.51389e-73
NC_014391.1\|WP_013289378.1\|7013772_7015086_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	3.58838e-119
NC_014391.1\|WP_013289386.1\|7023427_7024429_-\|membrane-protein-insertase-YidC	gnl\|CDD\|234941	PRK01315, PRK01315, putative inner membrane protein translocase component YidC; Provisional.	1.20035e-80
NC_014391.1\|WP_013289385.1\|7022626_7023217_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|224760	COG1847, Jag, Predicted RNA-binding protein [General function prediction only].	1.56279e-45
NC_014391.1\|WP_041784681.1\|7010177_7011131_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	1.13757e-155
NC_014391.1\|WP_013289388.1\|7025158_7025296_-\|50S-ribosomal-protein-L34	gnl\|CDD\|366117	pfam00468, Ribosomal_L34, Ribosomal protein L34.	1.46789e-08
NC_014391.1\|WP_013289379.1\|7015093_7016089_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	2.03089e-103
NC_014391.1\|WP_128136872.1\|7019949_7020756_-\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	1.54936e-84
NC_014391.1\|WP_013289382.1\|7018881_7019922_-\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	6.46838e-79

>NC_014391.1|WP_174361833.1|7021532_7022246_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MPPELAEAARALFGDRLDLAAAYAELLATDGVVRGLIGPRETPRLWERHLLNCAVVAERIPEGASVIDVGSGAGLPGLVLAIARPDLTVTLVEPLARRTAFLIEAVQRLGLTRDVRVFRGRAEEAAAGSRDREPLSADIVTARAVAPLDRLASWCLPLVAPGGRLVALKGASAADEITEHTEAVIRLGGATPELHRCGEGVIDPPATVVEVVRERVINPRRPKKPKRSRGGRRRGDR
>NC_014391.1|WP_128136872.1|7019949_7020756_-|ParA-family-protein
MPRPDRTRVMCVANQKGGVGKTTTTVNLAVALALHGNRVLVVDLDPQGNASTGLNVPHHTGVPDVYDCLIDSVPLEEVAQAVEGIPNLWCVPATIDLAGAEIELVSVVARESRLARAIAAYPGHFDYVFIDCPPSLGLLTVNALVAAQEVLIPIQCEYYALEGLNQLINNINLVRQHLNPKLEVSTILLTMYDRRTRLADAVEQDVRNHFGDKVLQAVIPRNVRVSEAPSYGQSVMTYDPGSRGATSYFEAAQEIAERGVKEPVSRNA
>NC_014391.1|WP_013289382.1|7018881_7019922_-|ParB/RepB/Spo0J-family-partition-protein
MKNRPRGGLGRGLGALIPTGPVPGAEPAATEPESSATAASPSTPVAGATAAITGGVGSTPPPAFEPEPQLSPVPGARFAEIPVDAIVPNPKQPRHVFDEEALEELKTSIQEVGFLQPIVVRQLDPEKFELVMGERRWRAAQAVGRETIPAIVRDTKDDAMLRDALLENIHRANLNPLEEAAAYQQLLEEFGATHEELARRIGRSRPQISNTIRLMNLPPAVQRRVAAGVLSAGHARALLSLDNAEAQEALAERIVREGITVRGAEELVHLALAEEPAKTAAAKRRPKPHAPALTDLADRLSDRFDTRVKVDIGRSKGKITIEFATVDDLERIVGIIGVGEDGQPEA
>NC_014391.1|WP_013289380.1|7016091_7016955_-|hypothetical-protein
MPDTPPSVPDFTQWPSFPFEGDLRVKQLDEPVPFEPPRRGEADRECTACNAPDEAYIWVGERWRVRAMDRPTGLPMVLILESRSHLDLGDLPNLLAAELGVMTVRLERAVRSLDGVARVHVNRWGDGSAHLHLWFLARPYGRLQLRGTFLSLWDSILPPISEEKWRENLAMVAAWLAEFGGRPLAEPPRIHWQAPSSLSPTSPANAAEEPEDEAVSVIEAADEIPESDAAAGLSDPSAGPSDPDPAPQAGPAPEHAGDSAPDSADEDDAGPDDAADDRPDAARTRES
>NC_014391.1|WP_013289379.1|7015093_7016089_+|D-alanine--D-alanine-ligase
MSDSPAAPPPVTGSTADELHVLVLAGGLSYERDVSLRSGRRVLDALRAVGVDAELRDADVALLPALTADPPDAVVIALHGATGEDGSLRGVLDLWDVPYVGCDARSSRLAWDKPSAKAVLREAGIPTPDWVALPHDRFSELGAVAVLDRIVDRLGLPLMVKPAQGGSGLGAAVVREAASLPAAMVGCFAYDQTALVERYVPGMDVAVSVLDLGKGPQALPPVEIVPRNGVYDYAARYTAGRTTWHAPARLDAATTARVTEVALAAHTALGLRDVSRVDLIVDAGGDPHVLEVNVSPGMTETSLLPLAIQAAGLDFGRVLGTLVTRAAARRR
>NC_014391.1|WP_013289378.1|7013772_7015086_+|PLP-dependent-aminotransferase-family-protein
MTGTTLDDYTDRYARRVRGMTASEIRALFAVASRPEVVSLAGGAPYIAALPLDAVGEMLGRLGSEHGATTLQYGIGQGTPELRERICEVMSLSGIDASCGASPEDVVVTVGGQQALDLVARLFLDPGDVVLAEGPTYVGALGVFQAAQAQVAHVPMDDEGLIPEALETAIADLARAGRRVKFLYTIPTYQNPAGVTLSEERRERVLDICERAGLLVVEDDPYGQLGFEGEAPRPLRARRRDGVFYLSTFSKTFAPGLRVGWILAPHAVRDKLVIASEAQILCPSAYAQSAVSTYLGTMPWRQQLKVYREVYRERRDALLDAMADLMPEGTTWTTPRGGLFVWATLPDGLDSKAMMPRAVAARVAYVPGTGFYADGTGTGNMRLNFSFPTPERIREGVRRLAGVMEQEIAMRKVFGAVGGARPRRRQGGSDAPGPDLA
>NC_014391.1|WP_013289377.1|7012824_7013490_-|hypothetical-protein
MSRRLVSLTLDTLEDLPRSCRSCVYWELDPVSAERACAAGDPGLEKEAWVSQTLLEWGSCGKLVYVDGMPAGFVMYAPPAYVPRSMAFPTSPVSADAALLMTAHVVPAFADGGLGRMLVQGVARDLTKRGIKAIEAFGDAKFGDDADDPARACVAPADFFLSVGFKTVRPHPRYPRLRLELRTALSWKSDVEYALEKLLGSMSPETLLRPVRPAPATRSTS
>NC_014391.1|WP_013477529.1|7011655_7012816_+|N-acetylmuramoyl-L-alanine-amidase
MRPIRPGDQGPAVAEIRTVLAGLELLPAEAGGDDYDAQTERAVRAFQQSRGLSVDGRVGAETWRALDAARWRFGARALYHAVPEPLTGEDVRSLQERLLEMGYDVGRADAIYGIRTSRAVAQFQREMGLKPDGSCGPHTVNALRRLGRKVVGGRPQWLRESDAIRQAGPTLIGRTVVIDPGHGGTDPGVVVPDGTLRWSEADLVHDLASRLEGRLAAAGVRVQLTRGPSPGDCLPDADRAQLANSLGADVFISLHTDGHANPEAEGVATYHYGTDNGVTSATGERLAGLVQREIVARTGLRDCRTHAKAWELLRLTRMPAVRVEVGYLTSPDDRARLVDPRFRDRVVEAIVAGVQRMYLPIERDVPTGSIDVSELRAIVAAGTVVD
>NC_014391.1|WP_013289375.1|7011169_7011493_+|thioredoxin
MGATKAVTDASFVSDVLQSDKPVLVDFWAEWCGPCRKVSPLLEEIAGEMKDQVTIVKLNIDENPETARAYRVMSVPTLTIFKNGQPVQSIAGAKPKGELVKLIESAL
>NC_014391.1|WP_041784681.1|7010177_7011131_+|thioredoxin-disulfide-reductase
MDEVRNLIIIGSGPAGYTAAVYAARANLKPLVIEGVQSGGALMTTTEVENFPGFADGILGPELMDNMRKQAERFGAEFLTDDVTRVELKDTGEIGSDAVSTVWVGETAYRAHAVILSTGSAWRPLGVPGEQEYLGHGVSSCATCDGFFFRNQHIVVVGGGDSAMEEASFLTRFAESVTIIHRRDSFRASKIMADRALGNEKIKVEWNSVVEEILGDDGKVNGVRVRNVHTGESKVLDVTGVFVAIGHDPRSELFRGQVEMDDEGYVKVQAPSTRTSVPGVFAAGDVVDHTYRQAITAAGTGCAAALDAERFIATIQG
>NC_014391.1|WP_013289385.1|7022626_7023217_-|single-stranded-DNA-binding-protein
MRPVTETSIPSADQSLDEETPVTAATETEDAAGEAREKKAPADSDLFRQSEIAADYVEGLLDILDYDGDIDELVSGGRPVVEVVGGRLQNLVGQRGATLEALQELTRLAVFRQTGTPSRLLLDVGGYRAARRKELAAVAKNAVEKVKEHGEPVRLEPMSAFERKCVHDVVNAMSGVESESEGVEPNRRIVVRPVAD
>NC_014391.1|WP_013289386.1|7023427_7024429_-|membrane-protein-insertase-YidC
MFSLDWIYYAISWILLTWHSAWDAIGVPVGAVIGTNWAWILAIVFLVVTVRVILFPVFVKQIKSQRAMQALQPKVKELQEKHKGDRETLQKEMMELYRKEKANPLMGCLPMFLQIPVFLGLFHTLRRLSPDNQGKTLYGWTVDQFNSASNATLFTAPISGKFGSTADELSRLGASTGTVKVVAGILVIIMIATTYLTSRQMILKTGWAEDPQQRMVQRLMLYGIPLSLLISGAIFPIGVIIYWVTNNLFTLGQQQWVLRKFPPPPTAKSTSAAKSTSGKGPVQPAKAGGLFGRKAAQPPAKAPAVAPKVAGPKPGAKPVNPKKGGSKPAKRQG
>NC_014391.1|WP_013477538.1|7024429_7024669_-|membrane-protein-insertion-efficiency-factor-YidD
MLLAPIIAYRRWISPALPARCRFYPSCSAYAVEAVSRHGALRGAWLTVRRLSRCHPFHPGGHDPVPEPGDRRRSDVTGA
>NC_014391.1|WP_030269559.1|7024710_7025124_-|ribonuclease-P-protein-component
MLAAAQRLRRSNDFAAAVRGGRRVGRGAVVVHLTLPEPIGTTATLSPEPARSLGAETSAPSRAGFVVSKAVGGAVVRNKVRRRLRHLVRERLGELPAGTTLVVRALPAAADATYARLGADLDAAIAAARAPRGRRSR
>NC_014391.1|WP_013289388.1|7025158_7025296_-|50S-ribosomal-protein-L34
MSKRTYQPNNRRRAKTHGFRLRMRTRAGRAIISTRRSKGRARLSA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_014391_8	8.1\|6596339\|18\|NC_014391\|PILER-CR	6596339-6596356	18	NC_014391.1	6604656-6604673	1	0.944

1. spacer 8.1|6596339|18|NC_014391|PILER-CR matches to position: 6604656-6604673, mismatch: 1, identity: 0.944

acgccggcgggccagccg	CRISPR spacer
acgccggcgggccggccg	Protospacer
*************.****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP042263	Litoreibacter sp. LN3S51 plasmid unnamed2, complete sequence	280034-280060	3	0.889
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	321665-321691	4	0.852
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP046568	Dietzia sp. DQ12-45-1b plasmid pI, complete sequence	45395-45421	5	0.815
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP006369	Aureimonas sp. AU20 plasmid pAU20b, complete sequence	240065-240091	5	0.815
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP031086	Paracoccus yeei strain CCUG 32053 plasmid pYEE8, complete sequence	1482-1508	5	0.815
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NC_012811	Methylorubrum extorquens AM1 megaplasmid, complete sequence	361022-361048	6	0.778
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP039697	Novosphingobium sp. ABRDHK2 plasmid pABRDHK22, complete sequence	676341-676367	6	0.778
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	210925-210951	6	0.778
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	LN997843	Streptomyces reticuli genome assembly TUE45, plasmid : II	225987-226013	6	0.778
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	GQ919031	Streptomyces phage ZL12, complete genome	7147-7173	6	0.778
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	1166898-1166924	6	0.778
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP022760	Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence	1069554-1069580	6	0.778
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP022789	Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence	1069543-1069569	6	0.778
NC_014391_7	7.3\|5509857\|33\|NC_014391\|CRT	5509857-5509889	33	NZ_CP021083	Deinococcus ficus strain CC-FR2-10 plasmid pDFI2, complete sequence	281815-281847	7	0.788
NC_014391_7	7.3\|5509857\|33\|NC_014391\|CRT	5509857-5509889	33	NC_010510	Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence	426937-426969	7	0.788
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	883299-883325	7	0.741
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NC_010372	Myxococcus fulvus strain 124B02 plasmid pMF1, complete sequence	1268-1294	7	0.741
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1002241-1002267	7	0.741
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP016313	Thermus brockianus strain GE-1 plasmid pTB1, complete sequence	340078-340104	7	0.741
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	1130138-1130164	7	0.741
NC_014391_7	7.5\|5509965\|27\|NC_014391\|CRT	5509965-5509991	27	NZ_CP015585	Roseomonas gilardii strain U14-5 plasmid 1, complete sequence	216336-216362	8	0.704

1. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP042263 (Litoreibacter sp. LN3S51 plasmid unnamed2, complete sequence) position: , mismatch: 3, identity: 0.889

gccgccgggcgcaccgccacccggcag-	CRISPR spacer
gctgcccggcgcaccgccaccc-gcagc	Protospacer
**.*** *************** ****

2. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.852

gccgccgggcgcaccgccacccggcag	CRISPR spacer
ccggccgggcgcaccgtcacccagcag	Protospacer
 * *************.*****.****

3. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP046568 (Dietzia sp. DQ12-45-1b plasmid pI, complete sequence) position: , mismatch: 5, identity: 0.815

gccgccgggcgcaccgccacccggcag	CRISPR spacer
ccgatcgagcgcaccgccacccggcag	Protospacer
 * ..**.*******************

4. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP006369 (Aureimonas sp. AU20 plasmid pAU20b, complete sequence) position: , mismatch: 5, identity: 0.815

gccgccgggcgcaccgccacccggcag--	CRISPR spacer
atcgccgggcgcaccgccacc--gccgcc	Protospacer
..*******************  ** *

5. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP031086 (Paracoccus yeei strain CCUG 32053 plasmid pYEE8, complete sequence) position: , mismatch: 5, identity: 0.815

gccgccgggcgcaccgccacccggcag	CRISPR spacer
tccgccgggcgcagcgccaccggggcg	Protospacer
 ************ ******* **  *

6. spacer 7.5|5509965|27|NC_014391|CRT matches to NC_012811 (Methylorubrum extorquens AM1 megaplasmid, complete sequence) position: , mismatch: 6, identity: 0.778

gccgccgggcgcaccgccacccggcag	CRISPR spacer
gccgacggacgcaccgccacccgcggt	Protospacer
**** ***.**************  .

7. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP039697 (Novosphingobium sp. ABRDHK2 plasmid pABRDHK22, complete sequence) position: , mismatch: 6, identity: 0.778

gccgccgggcgcaccgccacccggcag	CRISPR spacer
cgcgccgggcgcgccggcacccggcga	Protospacer
  **********.*** ********..

8. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 6, identity: 0.778

gccgccgggcgcaccgccacccggcag	CRISPR spacer
ggcgccgggcgcgccgccacccgaacc	Protospacer
* **********.**********.

9. spacer 7.5|5509965|27|NC_014391|CRT matches to LN997843 (Streptomyces reticuli genome assembly TUE45, plasmid : II) position: , mismatch: 6, identity: 0.778

gccgccgggcgcaccgccacccggcag	CRISPR spacer
gccgccgggctcaccgccaccgatctc	Protospacer
********** ********** . *

10. spacer 7.5|5509965|27|NC_014391|CRT matches to GQ919031 (Streptomyces phage ZL12, complete genome) position: , mismatch: 6, identity: 0.778

gccgccgggcgcaccgccacccggcag	CRISPR spacer
ggcgacgggcgcaccgccacccgcacc	Protospacer
* ** ******************

11. spacer 7.5|5509965|27|NC_014391|CRT matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 6, identity: 0.778

gccgccgggcgcaccgccacccggcag	CRISPR spacer
cgcgccggtcgcaccgccaccctgcgc	Protospacer
  ****** ************* **.

12. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP022760 (Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.778

gccgccgggcgcaccgccacccggcag	CRISPR spacer
cgcgccggtcgcaccgccaccctgcgc	Protospacer
  ****** ************* **.

13. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP022789 (Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.778

gccgccgggcgcaccgccacccggcag	CRISPR spacer
cgcgccggtcgcaccgccaccctgcgc	Protospacer
  ****** ************* **.

14. spacer 7.3|5509857|33|NC_014391|CRT matches to NZ_CP021083 (Deinococcus ficus strain CC-FR2-10 plasmid pDFI2, complete sequence) position: , mismatch: 7, identity: 0.788

gctgccgggcccacccgggggcggcgtgaacga	CRISPR spacer
gctgccgggcccacccgggcgaggcggtcaccc	Protospacer
******************* * ****   **

15. spacer 7.3|5509857|33|NC_014391|CRT matches to NC_010510 (Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence) position: , mismatch: 7, identity: 0.788

gctgccgggcccacccgggggcggcgtgaacga	CRISPR spacer
tcggcgcggccgacccggcggcggcgtgaacca	Protospacer
 * **  **** ****** ************ *

16. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 7, identity: 0.741

gccgccgggcgcaccgccacccggcag	CRISPR spacer
cacgccggccgcaccgccacccgcggt	Protospacer
  ****** **************  .

17. spacer 7.5|5509965|27|NC_014391|CRT matches to NC_010372 (Myxococcus fulvus strain 124B02 plasmid pMF1, complete sequence) position: , mismatch: 7, identity: 0.741

gccgccgggcgcaccgccacccggcag	CRISPR spacer
cgcctcgggcgcaccgccacccggagc	Protospacer
  * .******************* .

18. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 7, identity: 0.741

gccgccgggcgcaccgccacccggcag	CRISPR spacer
gatcccgggcgcaccgccacccgcttc	Protospacer
* . ******************* .

19. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP016313 (Thermus brockianus strain GE-1 plasmid pTB1, complete sequence) position: , mismatch: 7, identity: 0.741

gccgccgggcgcaccgccacccggcag	CRISPR spacer
gccgccaggcgcaccgccacctcctcc	Protospacer
******.**************.  .

20. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.741

gccgccgggcgcaccgccacccggcag	CRISPR spacer
gatcccgggcgcaccgccacccgcttc	Protospacer
* . ******************* .

21. spacer 7.5|5509965|27|NC_014391|CRT matches to NZ_CP015585 (Roseomonas gilardii strain U14-5 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.704

gccgccgggcgcaccgccacccggcag	CRISPR spacer
cagagcgggcgcaccgccacccggtgc	Protospacer
   . *******************..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1918869 : 2008527

Tupanvirus(20.0%)

transposase,integrase

attL 1915071:1915086|attR 1952718:1952733

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1915071:1915086	attL	NA	NA	NA	NA
WP_013285008.1\|1918869_1920006_+\|integrase	site-specific integrase	A0A1W6JTA0	Pseudomonas_phage	3.1e-08	23.6
WP_041798892.1\|1920461_1920683_+	hypothetical protein	NA	NA	NA	NA
WP_013285009.1\|1920666_1920918_+	hypothetical protein	NA	NA	NA	NA
WP_013285010.1\|1921086_1921695_+	hypothetical protein	NA	NA	NA	NA
WP_013285011.1\|1921988_1922369_-	hypothetical protein	NA	NA	NA	NA
WP_049794871.1\|1922861_1923194_+	hypothetical protein	NA	NA	NA	NA
WP_041799214.1\|1923383_1923929_-	hypothetical protein	NA	NA	NA	NA
WP_013285014.1\|1924100_1924883_+\|transposase	IS5-like element ISMau1 family transposase	NA	NA	NA	NA
WP_013285015.1\|1925074_1925851_+\|transposase	transposase	NA	NA	NA	NA
WP_013285016.1\|1925854_1926877_-	TauD/TfdA family dioxygenase	NA	NA	NA	NA
WP_083791314.1\|1926913_1927768_-	thioesterase	NA	NA	NA	NA
WP_013285018.1\|1927786_1929037_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_145755681.1\|1929033_1929303_-	hypothetical protein	NA	NA	NA	NA
WP_013285019.1\|1930306_1931644_+	MFS transporter	NA	NA	NA	NA
WP_013285020.1\|1931796_1932519_+	hypothetical protein	NA	NA	NA	NA
WP_013285021.1\|1932508_1934494_+	amino acid adenylation domain-containing protein	A0A2K9KZV5	Tupanvirus	7.1e-56	27.3
WP_114919807.1\|1934546_1935701_+	cytochrome P450	NA	NA	NA	NA
WP_013285023.1\|1936945_1937728_-\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_013285024.1\|1938156_1938861_+	RraA family protein	NA	NA	NA	NA
WP_013285025.1\|1938857_1939976_+	DUF2332 domain-containing protein	NA	NA	NA	NA
WP_013285026.1\|1939972_1940845_+	nucleotidyltransferase family protein	A0A127AW70	Bacillus_phage	4.0e-11	22.3
WP_013285027.1\|1940825_1941737_+	radical SAM protein	NA	NA	NA	NA
WP_013285028.1\|1942082_1943699_+	phosphopantetheine-binding protein	NA	NA	NA	NA
WP_013285029.1\|1943688_1944342_+	HAD family hydrolase	NA	NA	NA	NA
WP_013285030.1\|1944341_1945415_+	phosphotransferase	NA	NA	NA	NA
WP_041798905.1\|1945466_1947353_+	asparagine synthase (glutamine-hydrolyzing)	F2Y1H0	Organic_Lake_phycodnavirus	1.6e-20	26.2
WP_013285032.1\|1947421_1947655_+	acyl carrier protein	NA	NA	NA	NA
WP_049794823.1\|1947922_1948417_-	hypothetical protein	NA	NA	NA	NA
WP_013285033.1\|1948560_1948806_-	hypothetical protein	NA	NA	NA	NA
WP_013285034.1\|1948781_1949129_-	major facilitator superfamily protein	NA	NA	NA	NA
WP_041799221.1\|1949125_1950100_-	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	1.4e-44	35.2
WP_114919813.1\|1950436_1950772_-	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_145755722.1\|1951030_1952035_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_013285038.1\|1952031_1952445_-\|transposase	transposase	NA	NA	NA	NA
WP_157547438.1\|1952474_1953047_-	hypothetical protein	NA	NA	NA	NA
1952718:1952733	attR	NA	NA	NA	NA
WP_013285023.1\|1953176_1953959_-\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_157547400.1\|1955142_1956363_+	hypothetical protein	NA	NA	NA	NA
WP_157547401.1\|1956592_1956859_-	hypothetical protein	NA	NA	NA	NA
WP_013285041.1\|1957449_1957860_-	hypothetical protein	NA	NA	NA	NA
WP_157547402.1\|1958159_1958627_+	hypothetical protein	NA	NA	NA	NA
WP_041798909.1\|1959131_1959764_-	nucleoside monophosphate kinase	NA	NA	NA	NA
WP_041798911.1\|1959951_1961370_+	hypothetical protein	NA	NA	NA	NA
WP_013285045.1\|1961344_1964098_+	hypothetical protein	NA	NA	NA	NA
WP_013285046.1\|1964283_1964949_+	hypothetical protein	NA	NA	NA	NA
WP_013285047.1\|1965030_1966413_+\|transposase	IS1380 family transposase	A0A222ZN33	Mycobacterium_phage	9.5e-92	45.2
WP_013285048.1\|1967166_1968348_+	hypothetical protein	NA	NA	NA	NA
WP_013285049.1\|1968462_1972386_+	hypothetical protein	NA	NA	NA	NA
WP_013285050.1\|1972646_1973789_+	nucleoside monophosphate kinase	NA	NA	NA	NA
WP_083791358.1\|1973783_1974971_-	hypothetical protein	NA	NA	NA	NA
WP_145755800.1\|1975039_1977268_-	AAA family ATPase	K4I1H4	Acidithiobacillus_phage	6.8e-23	31.6
WP_145755799.1\|1977609_1978374_-	hypothetical protein	NA	NA	NA	NA
WP_145755798.1\|1978520_1978772_-	hypothetical protein	NA	NA	NA	NA
WP_151016190.1\|1978975_1979311_-	hypothetical protein	NA	NA	NA	NA
WP_013285055.1\|1979578_1979731_-	hypothetical protein	NA	NA	NA	NA
WP_013285056.1\|1979761_1980292_-	hypothetical protein	NA	NA	NA	NA
WP_041799227.1\|1980648_1981017_+	hypothetical protein	NA	NA	NA	NA
WP_013285058.1\|1981095_1981299_-	hypothetical protein	NA	NA	NA	NA
WP_013285059.1\|1982338_1982638_+	hypothetical protein	NA	NA	NA	NA
WP_041798916.1\|1983023_1984601_+	DUF2397 domain-containing protein	NA	NA	NA	NA
WP_013285061.1\|1984600_1985761_+	TIGR02678 family protein	NA	NA	NA	NA
WP_013285062.1\|1985757_1990092_+	hypothetical protein	NA	NA	NA	NA
WP_013285063.1\|1990088_1991231_+	DUF2399 domain-containing protein	NA	NA	NA	NA
WP_157547404.1\|1991447_1992698_-	hypothetical protein	NA	NA	NA	NA
WP_157547405.1\|1992704_1994243_-	hypothetical protein	NA	NA	NA	NA
WP_013285047.1\|1995016_1996399_-\|transposase	IS1380 family transposase	A0A222ZN33	Mycobacterium_phage	9.5e-92	45.2
WP_013285064.1\|1997026_1998070_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_013285066.1\|1998852_1999170_-	hypothetical protein	NA	NA	NA	NA
WP_030270966.1\|2000072_2000312_+	hypothetical protein	NA	NA	NA	NA
WP_013285067.1\|2001822_2002494_+	HNH endonuclease	NA	NA	NA	NA
WP_013285068.1\|2002691_2002865_+	hypothetical protein	NA	NA	NA	NA
WP_013285064.1\|2003288_2004332_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_013285069.1\|2004501_2005698_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_083791322.1\|2005992_2006367_+	hypothetical protein	NA	NA	NA	NA
WP_013285072.1\|2006363_2006672_+	hypothetical protein	NA	NA	NA	NA
WP_013283498.1\|2007244_2008171_-\|transposase	IS3 family transposase	Q6H9S3	Enterobacteria_phage	2.1e-50	38.8
WP_083791297.1\|2008167_2008527_-\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	5.8e-17	54.7

DBSCAN-SWA_2

4582376 : 4679801

Gordonia_phage(36.36%)

transposase,integrase

attL 4595331:4595348|attR 4644604:4644621

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085985943.1\|4582376_4583203_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_013287184.1\|4583300_4583759_+	DUF3592 domain-containing protein	NA	NA	NA	NA
WP_085985943.1\|4583937_4584763_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_041799053.1\|4584879_4585881_-	hypothetical protein	NA	NA	NA	NA
WP_013287186.1\|4586237_4591349_+	hypothetical protein	NA	NA	NA	NA
WP_013287187.1\|4591396_4592542_-	DUF4238 domain-containing protein	NA	NA	NA	NA
WP_157547414.1\|4592738_4593908_-	hypothetical protein	NA	NA	NA	NA
WP_013287189.1\|4594004_4594604_-	hypothetical protein	NA	NA	NA	NA
WP_145824182.1\|4594534_4595095_-	hypothetical protein	NA	NA	NA	NA
WP_013287190.1\|4595091_4596090_-	hypothetical protein	NA	NA	NA	NA
4595331:4595348	attL	NA	NA	NA	NA
WP_145824183.1\|4596546_4598058_-	hypothetical protein	NA	NA	NA	NA
WP_013287192.1\|4598129_4599584_+\|integrase	site-specific integrase	A0A1B0T6A8	Bacillus_phage	7.1e-29	29.1
WP_013287193.1\|4599765_4600830_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_157547415.1\|4600861_4601011_-	hypothetical protein	NA	NA	NA	NA
WP_013285064.1\|4601220_4602264_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_085985945.1\|4602797_4603451_-	choice-of-anchor M domain-containing protein	NA	NA	NA	NA
WP_013287195.1\|4603447_4604095_-	choice-of-anchor M domain-containing protein	NA	NA	NA	NA
WP_013287196.1\|4604842_4605781_-	anchored repeat-type ABC transporter permease subunit	NA	NA	NA	NA
WP_174361803.1\|4605780_4606494_-	anchored repeat-type ABC transporter ATP-binding subunit	A0A2R8FG22	Brazilian_cedratvirus	3.7e-15	31.3
WP_083791363.1\|4606520_4607456_-	choice-of-anchor M domain-containing protein	NA	NA	NA	NA
WP_013287199.1\|4607497_4609102_-	anchored repeat ABC transporter, substrate-binding protein	NA	NA	NA	NA
WP_174361804.1\|4609098_4610682_-	TIGR03773 family transporter-associated surface protein	NA	NA	NA	NA
WP_013287201.1\|4610803_4612018_-	DUF916 domain-containing protein	NA	NA	NA	NA
WP_013287202.1\|4612143_4613616_-	choice-of-anchor M domain-containing protein	NA	NA	NA	NA
WP_013287203.1\|4613665_4613971_-	30S ribosomal protein S14	NA	NA	NA	NA
WP_013287204.1\|4613970_4614138_-	50S ribosomal protein L33	NA	NA	NA	NA
WP_013287205.1\|4614137_4614374_-	50S ribosomal protein L28	NA	NA	NA	NA
WP_013287206.1\|4614677_4615979_+	GTP-binding protein	NA	NA	NA	NA
WP_013287207.1\|4615975_4616236_+	type B 50S ribosomal protein L31	NA	NA	NA	NA
WP_013287208.1\|4616232_4617102_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_013287209.1\|4617108_4617618_+	transcriptional repressor	NA	NA	NA	NA
WP_013287210.1\|4618725_4619130_-	transcriptional repressor	NA	NA	NA	NA
WP_013287212.1\|4619786_4621010_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_041799056.1\|4621051_4621387_-	(2Fe-2S) ferredoxin domain-containing protein	NA	NA	NA	NA
WP_157547440.1\|4621383_4622055_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_013287214.1\|4622114_4623341_-	GTP-binding protein	NA	NA	NA	NA
WP_013287215.1\|4623337_4623517_-	50S ribosomal protein L32	NA	NA	NA	NA
WP_083791336.1\|4623940_4624585_-\|transposase	IS3 family transposase	A0A1B3AZE5	Gordonia_phage	6.4e-75	68.6
WP_013285608.1\|4624562_4625489_-\|transposase	IS3 family transposase	Q6H9S3	Enterobacteria_phage	2.1e-50	38.8
WP_013283497.1\|4625485_4625797_-\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.2e-17	55.7
WP_049794835.1\|4625820_4626195_-\|transposase	IS3 family transposase	A0A1B3AZE5	Gordonia_phage	9.0e-21	49.1
WP_013287216.1\|4626191_4626509_-\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.7e-34	70.5
WP_145824155.1\|4627223_4627871_-	hypothetical protein	NA	NA	NA	NA
WP_013287219.1\|4628414_4629086_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_013287220.1\|4629082_4629490_+	hypothetical protein	NA	NA	NA	NA
WP_041799059.1\|4629953_4630649_+	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_013287223.1\|4630645_4631278_+	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_013287224.1\|4631252_4632956_-	carbamoyltransferase	A0A1B1IVF2	uncultured_Mediterranean_phage	3.7e-29	28.7
WP_013287225.1\|4632948_4634322_-	radical SAM protein	NA	NA	NA	NA
WP_013287226.1\|4634309_4635533_-	radical SAM protein	NA	NA	NA	NA
WP_013287227.1\|4635624_4635801_-	hypothetical protein	NA	NA	NA	NA
WP_013287228.1\|4635963_4637289_+	hypothetical protein	NA	NA	NA	NA
WP_013287229.1\|4637364_4637871_-	hypothetical protein	NA	NA	NA	NA
WP_145824156.1\|4638035_4638620_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_145824157.1\|4638805_4639522_-	hypothetical protein	NA	NA	NA	NA
WP_013287232.1\|4639731_4640487_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_013287233.1\|4640518_4640947_-	hypothetical protein	NA	NA	NA	NA
WP_013287234.1\|4641083_4642604_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	2.2e-09	28.6
WP_145824158.1\|4642600_4643515_-	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_013287236.1\|4643595_4644474_-	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_013287237.1\|4644505_4645321_-	methyltransferase domain-containing protein	NA	NA	NA	NA
4644604:4644621	attR	NA	NA	NA	NA
WP_013287238.1\|4645340_4646681_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_174361721.1\|4646677_4647301_-	hypothetical protein	NA	NA	NA	NA
WP_013287240.1\|4647323_4647734_-	roadblock/LC7 domain-containing protein	NA	NA	NA	NA
WP_174361722.1\|4647733_4650217_-	nitrate- and nitrite sensing domain-containing protein	NA	NA	NA	NA
WP_013287242.1\|4650761_4651649_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013287243.1\|4651645_4651864_+	DUF397 domain-containing protein	NA	NA	NA	NA
WP_157547416.1\|4652068_4652497_+	hypothetical protein	NA	NA	NA	NA
WP_013287244.1\|4652559_4653531_+\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_157547417.1\|4653593_4654550_+	hypothetical protein	NA	NA	NA	NA
WP_145824159.1\|4654552_4655131_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013287247.1\|4655363_4655822_+	DNA-binding protein	NA	NA	NA	NA
WP_167545752.1\|4655843_4657085_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_013287248.1\|4657393_4658281_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	1.7e-17	36.2
WP_145824154.1\|4658280_4659501_-	hypothetical protein	NA	NA	NA	NA
WP_013287250.1\|4659876_4660011_+	FxLD family lanthipeptide	NA	NA	NA	NA
WP_013287251.1\|4660113_4663134_+	lantibiotic dehydratase	NA	NA	NA	NA
WP_013287252.1\|4663130_4664387_+	lanthionine synthetase C family protein	A0A2H4PQH9	Staphylococcus_phage	2.1e-05	20.4
WP_013287253.1\|4664401_4666483_+	methyltransferase, FxLD system	NA	NA	NA	NA
WP_041799290.1\|4666613_4667711_+	hypothetical protein	NA	NA	NA	NA
WP_013287255.1\|4667986_4669228_+	methyltransferase, FxLD system	NA	NA	NA	NA
WP_041799292.1\|4669245_4669830_+	kinase	NA	NA	NA	NA
WP_013287257.1\|4669971_4671297_+	MFS transporter	NA	NA	NA	NA
WP_013287258.1\|4671293_4671938_+	3'-5' exonuclease	NA	NA	NA	NA
WP_013287259.1\|4672104_4673142_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_013287260.1\|4673483_4674284_+	hypothetical protein	NA	NA	NA	NA
WP_145824215.1\|4674397_4674922_-	hypothetical protein	NA	NA	NA	NA
WP_013287262.1\|4675924_4676347_+	hypothetical protein	NA	NA	NA	NA
WP_145824214.1\|4676382_4677504_+	hypothetical protein	NA	NA	NA	NA
WP_013287264.1\|4677500_4677854_+	hypothetical protein	NA	NA	NA	NA
WP_145824219.1\|4677915_4678536_-	hypothetical protein	NA	NA	NA	NA
WP_013287266.1\|4678907_4679801_+\|transposase	IS5 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014391

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection