CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NC_018580	Gordonia sp. KTR9 plasmid pGKT2, complete sequence	0 crisprs	NA	0	1
NC_018583	Gordonia sp. KTR9 plasmid pGKT3, complete sequence	0 crisprs	NA	0	1
NC_018582	Gordonia sp. KTR9 plasmid pGKT1, complete sequence	0 crisprs	csa3	0	0
NC_018581	Gordonia sp. KTR9, complete sequence	7 crisprs	csa3,cas3,DinG,DEDDh,cas4,WYL,RT	2	2

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

69504 : 121296

Mycobacterium_phage(22.22%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033206723.1\|69504_70824_+\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_014928929.1\|71138_71810_+	hypothetical protein	NA	NA	NA	NA
WP_148281345.1\|71981_72188_+	hypothetical protein	NA	NA	NA	NA
WP_014928931.1\|72172_73318_+	hypothetical protein	NA	NA	NA	NA
WP_014928932.1\|73515_76341_+	class I SAM-dependent DNA methyltransferase	Q6NE04	Leptospira_phage	6.8e-145	35.5
WP_044508747.1\|76607_77105_+	hypothetical protein	NA	NA	NA	NA
WP_148281346.1\|77314_77584_+	hypothetical protein	NA	NA	NA	NA
WP_193363311.1\|77863_78475_+	hypothetical protein	NA	NA	NA	NA
WP_014928937.1\|78471_80454_+	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_014928938.1\|80655_81771_-	hypothetical protein	NA	NA	NA	NA
WP_044508754.1\|81853_82219_-	hypothetical protein	NA	NA	NA	NA
WP_014928940.1\|83144_85499_+	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_044508756.1\|85675_85945_-	hypothetical protein	NA	NA	NA	NA
WP_014928941.1\|86160_86691_-	M15 family metallopeptidase	A0A286MQD6	Mycobacterium_phage	5.4e-11	32.4
WP_144066114.1\|87069_87681_+	hypothetical protein	NA	NA	NA	NA
WP_014928943.1\|87776_88958_-	hypothetical protein	NA	NA	NA	NA
WP_110117389.1\|90516_91497_+	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_004020624.1\|91522_91786_-	MMPL family transporter	NA	NA	NA	NA
WP_004020623.1\|92045_92522_+	PaaI family thioesterase	NA	NA	NA	NA
WP_004020622.1\|92527_93553_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_004020621.1\|93652_93973_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_004020620.1\|93999_95391_+	cytochrome P450	NA	NA	NA	NA
WP_014928948.1\|95387_96587_+	FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	2.0e-05	23.7
WP_004020618.1\|96583_97255_+	transglutaminase domain-containing protein	NA	NA	NA	NA
WP_172622077.1\|97366_98380_+	DUF4872 domain-containing protein	NA	NA	NA	NA
WP_014928953.1\|101534_104567_-	RND family transporter	NA	NA	NA	NA
WP_004021766.1\|104649_104988_-	DUF4873 domain-containing protein	NA	NA	NA	NA
WP_004021765.1\|105121_106090_+	diiron oxygenase	NA	NA	NA	NA
WP_004021764.1\|106251_107772_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_004021763.1\|107819_108689_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_004021762.1\|108685_109759_+	ferredoxin--NADP reductase	I3ULH6	Synechococcus_phage	9.6e-07	36.2
WP_004021761.1\|109748_110654_+	alpha/beta hydrolase	A0A2R4AQZ9	Mycobacterium_phage	4.7e-07	24.7
WP_004021760.1\|110739_111492_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_004021759.1\|111792_112419_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_033206569.1\|112505_115547_+	MMPL family transporter	NA	NA	NA	NA
WP_004021756.1\|116353_117118_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.9e-49	42.9
WP_165629285.1\|117124_118423_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_004022138.1\|118571_118889_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	1.4e-51	100.0
WP_014928955.1\|118891_119632_+\|transposase	IS3 family transposase	A0A1B3AZE5	Gordonia_phage	5.2e-113	100.0
WP_101819295.1\|119801_121001_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	3.8e-36	31.2
WP_014928957.1\|121065_121296_+\|transposase	transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_018580

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

83515 : 89461

Gordonia_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014924706.1\|83515_85510_+	cutinase family protein	A0A2K9VEH2	Gordonia_phage	4.1e-11	32.6
WP_044505519.1\|85603_86119_-	single-stranded DNA-binding protein	A0A2H4JEL4	uncultured_Caudovirales_phage	1.5e-53	86.8
WP_014924708.1\|86334_86640_-	hypothetical protein	B5LJ42	Mycobacterium_phage	2.3e-06	33.0
WP_014924709.1\|86654_87944_-	replication-associated recombination protein A	G3MBE0	Bacillus_virus	1.6e-80	43.4
WP_044505521.1\|88009_88510_-	hypothetical protein	NA	NA	NA	NA
WP_044505522.1\|88701_89016_-	hypothetical protein	M9MU70	Rhodococcus_phage	9.6e-08	36.6
WP_044505523.1\|89146_89461_-	hypothetical protein	A0A1B3AYN2	Gordonia_phage	1.5e-13	54.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NC_018581

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CRISPR-Cas detection and classification

Crispr_ID: NC_018581_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018581_1

545773-545883

Orphan

Consensus_repeat	Method
ACGACGACGCCGCGACGTCGTCTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018581_1

>merge|NC_018581|1|545773-545883|CRISPRCasFinder
GCGACGACGACGCCGCGACGTCGTCTGAGGCGAAGGCTTCGACTCGGCTCCTCGCTGCGCTCGTCGCCGGCTCAGCCGGCAGGAGAACGACGACGCCGCGACGTCGTCTGA

>NC_018581|1|1|545773-545883|CRISPRCasFinder
GCGACGACGACGCCGCGACGTCGTC	TGAGGCGAAGGCTTCGACTCGGCTCCTCGCTGCGCTCGTCGCCGGCTCAGCCGGCAGGAGA
ACGACGACGCCGCGACGTCGTCTGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_018581.1\|WP_014925186.1\|537822_538617_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NC_018581.1\|WP_014925200.1\|556120_556468_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379642
NC_018581.1\|WP_014925191.1\|543784_545152_-\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341066
NC_018581.1\|WP_014925184.1\|536254_537130_+\|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl\|CDD\|130274
NC_018581.1\|WP_044505755.1\|540739_541441_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NC_018581.1\|WP_014925198.1\|552196_553162_+\|TIGR00341-family-protein	unknown	unknown	gnl\|CDD\|377221
NC_018581.1\|WP_044505757.1\|542498_543776_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|225153
NC_018581.1\|WP_044505765.1\|548047_549400_+\|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl\|CDD\|274581
NC_018581.1\|WP_014925193.1\|546602_547100_+\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_010844816.1\|540378_540732_-\|DUF2304-domain-containing-protein	unknown	unknown	gnl\|CDD\|378376
NC_018581.1\|WP_014925196.1\|549396_550371_+\|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl\|CDD\|378355
NC_018581.1\|WP_014925192.1\|545887_546469_-\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_010844815.1\|539740_540283_-\|EXLDI-protein	unknown	unknown	gnl\|CDD\|275138
NC_018581.1\|WP_044505763.1\|547109_547877_-\|Clp-protease	unknown	unknown	gnl\|CDD\|223616
NC_018581.1\|WP_044505767.1\|553158_554112_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561
NC_018581.1\|WP_044505753.1\|538625_539588_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NC_018581.1\|WP_014925197.1\|551599_551989_+\|PLDc-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|234967
NC_018581.1\|WP_010844827.1\|550351_551413_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274817
NC_018581.1\|WP_014925189.1\|541532_542387_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133039
NC_018581.1\|WP_014925185.1\|537145_537763_+\|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein	unknown	unknown	gnl\|CDD\|376414

Protein	Function_ID	Function_description	E-value
NC_018581.1\|WP_014925186.1\|537822_538617_-\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	1.13828e-10
NC_018581.1\|WP_014925200.1\|556120_556468_+\|N-acetyltransferase	gnl\|CDD\|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	1.96518e-19
NC_018581.1\|WP_014925191.1\|543784_545152_-\|M1-family-metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	2.7026e-171
NC_018581.1\|WP_014925184.1\|536254_537130_+\|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl\|CDD\|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	4.90167e-180
NC_018581.1\|WP_044505755.1\|540739_541441_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.24773e-43
NC_018581.1\|WP_014925198.1\|552196_553162_+\|TIGR00341-family-protein	gnl\|CDD\|377221	pfam04087, DUF389, Domain of unknown function (DUF389). Family of hypothetical bacterial proteins with an undetermined function.	6.92251e-36
NC_018581.1\|WP_044505757.1\|542498_543776_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|225153	COG2244, RfbX, Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only].	1.70622e-07
NC_018581.1\|WP_044505765.1\|548047_549400_+\|ergothioneine-biosynthesis-protein-EgtB	gnl\|CDD\|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	0
NC_018581.1\|WP_010844816.1\|540378_540732_-\|DUF2304-domain-containing-protein	gnl\|CDD\|378376	pfam10066, DUF2304, Uncharacterized conserved protein (DUF2304). Members of this family of hypothetical archaeal proteins have no known function.	6.04209e-20
NC_018581.1\|WP_014925196.1\|549396_550371_+\|L-histidine-N(alpha)-methyltransferase	gnl\|CDD\|378355	pfam10017, Methyltransf_33, Histidine-specific methyltransferase, SAM-dependent. The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring.	3.4482e-142
NC_018581.1\|WP_010844815.1\|539740_540283_-\|EXLDI-protein	gnl\|CDD\|275138	TIGR04342, hypothetical_protein, EXLDI protein. The most conserved region in this protein family is the C-terminal pentapeptide, with motif ExLDI. Members from the Firmicutes average about 120 amino acids in length, while members from the Actinobacteria have an additional 45-residue amino-terminal segment not included in the model. In it is suggested that the member from Streptococcus mutans UA159, and its homologs, participate in bacteriocin production, export, or immunity.	1.05024e-26
NC_018581.1\|WP_044505763.1\|547109_547877_-\|Clp-protease	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	2.31589e-10
NC_018581.1\|WP_044505767.1\|553158_554112_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	1.67954e-137
NC_018581.1\|WP_044505753.1\|538625_539588_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	1.43497e-101
NC_018581.1\|WP_014925197.1\|551599_551989_+\|PLDc-N-terminal-domain-containing-protein	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	0.000508823
NC_018581.1\|WP_010844827.1\|550351_551413_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274817	TIGR03858, LLM_2I7G, probable oxidoreductase, LLM family. This model describes a highly conserved, somewhat broadly distributed family withing the luciferase-like monooxygenase (LLM) superfamily. Most members are from species incapable of synthesizing coenzyme F420, bound by some members of the LLM superfamily. Members, therefore, are more likely to use FMN as a cofactor.	0
NC_018581.1\|WP_014925189.1\|541532_542387_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133039	cd04196, GT_2_like_d, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	2.4239e-18
NC_018581.1\|WP_014925185.1\|537145_537763_+\|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein	gnl\|CDD\|376414	pfam00908, dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. This family catalyze the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	7.12529e-80

>NC_018581.1|WP_014925191.1|543784_545152_-|M1-family-metallopeptidase
MPGKFGLGSRGNSGQPVLGAPADVLDPYLPDNGNLGYRISRYDLELEYKVASNRLEGTAVLTATSYAELKRFTLDLAGSLSVQRVSVNDKRARYSHRRHKLTITPDSPLPPGGAMTITVRYHGSPHPIRGPWGEVGWEELTDGALCANQPNGAASWFPCDDHPSAKAPYRISITTDSPYHALANGVLESKRVRAAHTTWVYEQVEPMPTYLASIQIGQYKQISLASKPIPVAGLIPARLEENFGVDFGRQTEMVSAFVEMFGPYPFPRYTVVVTDDDLEIPIEAQSFSTFGANHCDGSRHAERLIAHELAHQWFGNSVTAARWRDIWLHEGFACYAEWLWSQHSGGRSADEWARHYYQKLESSPVRVPLADPGPRKMFDDWIYKRGALTLHALRLTIGDGDFFALLQRWTDKYRYGSVTTEDFMALAATHSSKPLKGLWDEWLFTPELPPFPGPS
>NC_018581.1|WP_044505757.1|542498_543776_-|polysaccharide-biosynthesis-protein
MTTDPTTPGPQAGPAGPPGATDAASLGRVTIATVVAAASGYIVLLLAARHLGAVGYGVFAVFWAAYGLVTGAQNGQLQETTRAVRTAESEGRARSRPLLVNTGIGLGLAVLVIATSPLWSTRVFTDDRGLSVLLLAVGVASFAVYAHLCGALSGRLNWSSFAALLSVDALIRLAGAGIAVAAGWGTTAFLVVTVIGSVSWCVLLATSASARRAIGVAGDIPPRRLAANTLTAMAAAAASAVLVMGFPVLINLTTDLHGGPDADETRTIGALVLAVTLTRAPLLVPLNSFQGVLISRFVDRRDRRLAALGAPLGIVAAVGGVGVLGAWLVGPWLLRSVFGADFDLDGLVVALLTLGATCLALLTVTGAAAIAAGSHRWYAAGWWVSTLVAVAVLLLPFDVATRTCLALVVGPVIGLGVHLVGVLRA
>NC_018581.1|WP_014925189.1|541532_542387_+|glycosyltransferase-family-2-protein
MTIDVMMPFYGDVAQFQQAVTSVLEQDDPELRLVVVDDCHPDPTPRRWLDSLGDARVHYLRNETNLGVNGNFRRCVDLVTADWFVVMGCDDLMHRDYLSTVRRLARHHPDAAVIAPGVDVIDENGQPVTPLGDRIKSVLAPPRATVLAGERLATTLYHGNWTYFPSLLWRTAAVREVGFRPGLEIVLDLALLVDLAGAGGSLVYDPEVVFSYRRHSASVSSVQAVDGRRFAEENRFFAEEAERCAARGWPKAARAARWHATSRLNHLSARVGAGIGRLRGSSGS
>NC_018581.1|WP_044505755.1|540739_541441_-|glycosyltransferase-family-2-protein
MADPTTNADVWLVVPVFNEGQVIREVATKARETFPNVVCVDDGSSDNSADEIRAAGVHLVRHPVNLGQGAAIQTGVEYARRRPGARFFVTFDADGQHQVDDVSAMIERLRREPVDIIVGTRFADGRSESVPLLRRMALRTIVFLSPRTRRLGLSDAHNGLRAFNKTVADQLDLLMSGMSHASEFIALIDHHRWRVAEQPVTILYTDYSRAKGQSLINGVNIVADGLFHTRMRK
>NC_018581.1|WP_010844816.1|540378_540732_-|DUF2304-domain-containing-protein
MIWFQVLAILGLIALVGFFVVNRGTARASAGVKLLFVAFIGFGVYAMLRQDDVTWVANKIGIQRGLDLVLFLLVIAFAFTTVSTYLRFRDLEVKYARLARAIALQDAERENRGGTGD
>NC_018581.1|WP_010844815.1|539740_540283_-|EXLDI-protein
MPNKTIYVSDEDIKVLERAQQVSGGNLSGAVVEALRAYVRAADYRDAGYEEVVLRDGPDGVRRKRFFGRLLAEETEYDEITGNATKLSSYEGRTGKIVLAVHHVDWANYGVTHRQKTGNWLKDLTGLPSVRSLFTADLPDWGDYRVDIVDTAEQLKPLVPERFYARTAAALRPEVEDLDV
>NC_018581.1|WP_044505753.1|538625_539588_-|ATP-binding-cassette-domain-containing-protein
MTPTAISAVGLTKSFGDHTVLDGIDLRVPAGSVFALLGPNGSGKTTTVKILSTLSQQDAGDVEIAGLDPRTDRAEICAQIGLTGQFAAVDTLLTGRENLTMVARLRHLSKTATRERVDRLLDDFDLTEAADRRVADYSGGMTRRLDLAMTLVGEPSIIFLDEPTTGLDPRSRRAVWDTVRGLVAGGTTIFLTTQYLEEADHLADRIAVLDRGRIVAEGTAAELKRLVPGGYIRIDFTDADDLERARAQFPSAIDTPGENTLAVPGGAGIGAVRDVLATLDQARIDAAGISVHTPDLDDVFLTITGRTAATATATATATAN
>NC_018581.1|WP_014925186.1|537822_538617_-|ABC-transporter-permease
MTTTLDHTLSDSAVMLRRNLIRLRRYPTMMFSTIAMPVVILLMMTYFFGGAIESALAADGPLDGKYINYLLPGLLLFVPSFLTVAVAVSVNQDVTEGIINRLRSLATPPTAILAGHFVGALIQGIVAVVFLLAVAFALGFRADASLLDWFAAGGLLLLLTAGLVWIAVAMGVVAPNPESASNMPLPLLFLPYLGSGLVPTDSMPNGVRQFAEYQPFSPIADTLRGLLMGLDISDRWPWALGWCLLFLVVGYVWAVTAFRRSTTG
>NC_018581.1|WP_014925185.1|537145_537763_+|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein
MKVRPLAVEGAWEFTPVQHGDARGLFAEAFKADVLAEAIGHRFDLAQVNLSVSAAGVLRGVHFADVPPGQAKYVTCPGGAILDVIVDIRVGSPTFGAYDTVLLDDVDRRAVYLSEGLGHAFCSLADNSTVTYLCSTGYNPTGEHGINPLDPELDIEWPTQARDGSPLEFELSPKDTAAPGLSEARESGLLPRYDEVADHLRSRRD
>NC_018581.1|WP_014925184.1|536254_537130_+|glucose-1-phosphate-thymidylyltransferase-RfbA
MRGIILAGGTGTRLHPITQGVSKQLVPVYDKPMIYYPLSTLMLAGIRDILIITTPHDAPAFENLLGNGDQFGIDLTYKTQPSPDGLAQAFVLGADHIGTESVALVLGDNIFYGPGLGSRLQGFENVDGGAVFAYWVANPEAYGVVDFDADGTAISLEEKPAQPKSNFAVPGLYFYDNDVVDIARDLKPSARGEYEITDVNAHYLERGKLSVTVLPRGTAWLDTGTFDSLLDAGNFVRTVEQRQGLKIAVPEEIAWRQGYLDDDELRARADKLRKSGYGDYLLELLARGKGF
>NC_018581.1|WP_014925192.1|545887_546469_-|hypothetical-protein
MSRVIEEMEAEAQALLSAGEYDHALAEFSVLREIRSRREGPYSVMYLSNLHDCVRCMSHLMLWSDASHLCRELHGKYVRTHGRAGSDTVDVAKHWAWALVHLHDYPPAVRLYLLTADALWDSDPGQAQRLLGAAVIHRHDTDPLALLSPGLIDGVGLRHADEERKTIARLVAALADTGAVSTSTATIDGLAFA
>NC_018581.1|WP_014925193.1|546602_547100_+|hypothetical-protein
MKDDIGSTPEGSDGEYSLDEDDQLQPEDTLVDRGVDDVLDEGYSPPDRVPKGAVHGLTSREQAEGETLDERLAEEEPDVGAVDPLDEITAEERSRTDWRAHDSDRDDEFEEDDEVGDRRAGRLIAPDAGSGIDTESEAFAEDAGIDGAGASAEEAAVHYISDTPD
>NC_018581.1|WP_044505763.1|547109_547877_-|Clp-protease
MTQSPIPLRLDDLISAIRKVHPDPLDQLSDAVVAAQHLGDVADSLIGHFVDQARRSGASWTAIGASMGVSKQAAQKRFVDRVSPVSGNEAAAADNPFSRFTPRAANVLMTANAAAAADRAEHVTPAHFAQSLTAEPKSLVFVVLQELGVGIDAWRTAVAPLIPATREIADDEATSVVPYDDAAKAVLEATVGVALDLGHNYIGTEHLLLGFFADPALADVMTGLGLTADAIRATIVDALAQVMEGVPSTDRADEA
>NC_018581.1|WP_044505765.1|548047_549400_+|ergothioneine-biosynthesis-protein-EgtB
MSITEPSVRPQSAAAQSAATPSATSRSGEVAEVPSPSGVVTDVARRFLDVRTLTDTLAERLSPEDQTPQSMTEASPAKWHRAHVTWFFEEFILRQDPAYTVYDETFRYLFNSYYEAVGERHPRPDRGLVTRPGVRDVTRYREHVDAAMVDRLERGTLDDAALELVELGCNHEQQHQELLLMDIKHLFSTHAFGPVYVDREPDEPGIAKPLGWRQFDGGVVEVGALGSGFSYDNEGPRHRVYLEDFEIADRVVTNADWLEFMADDGYRRAEFWLSDGWATIRETGWEAPGYWRDETGARSVDPADWTTYTLSGRRRIVPDEPVLHVSFYEADAFARWAGARLPTEFEWEIAAGSLGAERGALLDPGRCHPGRAGSAMIGDVWEWTASAYLPYPGFVPANGAVGEYNGKFMSDQHVLRGASAVTPAGHERLTYRNFFPAESRWVFSGLRLAR
>NC_018581.1|WP_014925196.1|549396_550371_+|L-histidine-N(alpha)-methyltransferase
MSLDSDTPVETATEGLAADALSGLWQQPPVLPTKWLYDERGSKLFDEITRLPEYYPTRRETAILRARSAEIASTTRAEVIVELGSGTSTKTRLLLDAFVDAAADGERPTYVPVDVSTEMLTATADVLAVDYPGIDVVPVVADFTEPDLDLPPADGPRLAVFLGGTIGNFDPAARAEFYRAMVGSLSPGDYFLLGTDLVKDTGRLVAAYDDSAGVTADFNRNMIEVLRAGLDARGLYTDDFEHIARWNPGEHRIEMWLRARRDVDAYFGVLGRSWRVPAGTEIHTEISTKFEPEALASELESAGLTVVSAWTDPAGDFQLTLTRR
>NC_018581.1|WP_010844827.1|550351_551413_-|LLM-class-flavin-dependent-oxidoreductase
MESHAAVTDVELGLDTFGDITAEPDGALRSGARTLRDLLEQGVLADEVGVDFLGVGEHHRDDYAVSAPEVVLGAIAARTTRMRLGSAVTVLSSDDPIRVFQRFSTVDALSSGRAEVILGRGSFTESFPLFGYDLADYEELFSDKLALFAELRTGRPVSWSGSTRGPLQAQTVYPELENPPLPTWIAVGGSPESVVRAASYGLPLMLAIIGGDPLRFQPYVDLYHRALREMDKSPLPVGVHSPGHVADTDAQAREELWPHYREYVGRIGRERGWPPPTRIEFERSTGPGGSLYVGSPETVAAKIASTVRALGLSRFDLKYSHGTLGHAELMRSIELYGTQVIPRVRELLSVGSG
>NC_018581.1|WP_014925197.1|551599_551989_+|PLDc-N-terminal-domain-containing-protein
MWDSFWDFIWYTIVIFAFVAYLIVLWHIISDLFRDKAASGWQKAAWVVLLIIFPYITAIVYLLAKGKGMAERQREAYSEAKQASDEYIRSVAGATPTQQIADAKNLLDSGAITPQEFEHLKSKALGTAV
>NC_018581.1|WP_014925198.1|552196_553162_+|TIGR00341-family-protein
MLDLIPENQRRTVDELDDRLDLSSGDVRAKQSAFWLMLFLSSVIAAAGVASDSTATVIGAMIVAPLATPILGVGLGVVTGRGRLALTSLLYVGAGMVMVIVIGIVVAQILPNPSTVLANSQVVGRTSPTLMDLLAALATGLVGSIAVTRRDLGDVLPGVAIAISLVPPLAVTGVCFGSGAPSLAIGAFILFASNMIAMIITCTVVLVFARYHDVADVGRRRRRRAYVVLSAAFVLVTVPMVLNSLSAVWVRQVHDATEQWLADTPGAEVSGVTWHGGTATISVLGPEKLPPLSELEESVHDLLPWESDIVVIHDVGERLDG
>NC_018581.1|WP_044505767.1|553158_554112_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MGTVNAGRRTVDENRRTVDGNQRTVDEQAFVGLPIGPPGSVPTRVLTIAGSDSGGGAGIQADMRTFALLGVHGCVAVTAVTVQNSLGVTGFEEITPQTVAAQIDSVVGDIGVAAAKTGMLASAPIIEAIVEQCGRSGIGRDSSVPLVVDPVCASMHGNQLLADSALDTLRHNLFPLATVVTPNLDEVRLITGIEVTDAASQRDAARALLDLGPRWALVKGGHLRASDQSPDLLYDGEEFIELSHERIDTPHDHGAGDTLAAAIACALAHGLPVPESVAFAKSWVTRCLAAAYPLGAGHGPVNPLWRLGVRSEDQRPS
>NC_018581.1|WP_014925200.1|556120_556468_+|N-acetyltransferase
MLRKHRQRPPQSAKSILQQISQVVHNPDRDRFELWVAGDLVGVLGYSTETVDGQTTITVLHTVLYDEYSGHGLATRLTRTVVHHAREQGARLRPVCTFTKRYLDSHPGIVTLAPV

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Crispr_ID: NC_018581_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018581_2

906679-906755

Orphan

Consensus_repeat	Method
GCAGGGTGACGCCGAGCTGGGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018581_2

>merge|NC_018581|2|906679-906755|CRISPRCasFinder
GCAGGGTGACGCCGAGCTGGGTCTCCATCGCGCGGATCCGTGCCGACACCGCCTGCTGGGTGACGCCGAGCTGGGTC

>NC_018581|2|2|906679-906755|CRISPRCasFinder
GCAGGGTGACGCCGAGCTGGGTC	TCCATCGCGCGGATCCGTGCCGACACCGCCT
GCTGGGTGACGCCGAGCTGGGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018581.1\|WP_148281250.1\|896337_897150_-\|esterase-family-protein	unknown	unknown	gnl\|CDD\|223700
NC_018581.1\|WP_044505906.1\|910888_911440_+\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014928743.1\|903890_904796_+\|acetaldehyde-dehydrogenase-(acetylating)	unknown	unknown	gnl\|CDD\|236227
NC_018581.1\|WP_010842126.1\|916099_916702_+\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|214900
NC_018581.1\|WP_044507604.1\|906949_908098_+\|TDT-family-transporter	unknown	unknown	gnl\|CDD\|187760
NC_018581.1\|WP_010842127.1\|915186_916098_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|132257
NC_018581.1\|WP_014925472.1\|908211_909759_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|365860
NC_018581.1\|WP_014925467.1\|900968_902111_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173841
NC_018581.1\|WP_014925469.1\|904792_905887_+\|4-hydroxy-2-oxovalerate-aldolase	unknown	unknown	gnl\|CDD\|181282
NC_018581.1\|WP_044505903.1\|899910_900972_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NC_018581.1\|WP_014925468.1\|902107_902920_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|180298
NC_018581.1\|WP_010842128.1\|913955_915140_+\|flavin-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|173848
NC_018581.1\|WP_014925473.1\|909939_910734_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NC_018581.1\|WP_014928745.1\|912490_913729_-\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	unknown	unknown	gnl\|CDD\|239607
NC_018581.1\|WP_014925463.1\|897305_897716_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NC_018581.1\|WP_044505901.1\|897717_899064_-\|glycosyl-transferase	unknown	unknown	gnl\|CDD\|224732
NC_018581.1\|WP_014925465.1\|899259_899883_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_018581.1\|WP_044505908.1\|911414_911942_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_018581.1\|WP_014928742.1\|903065_903854_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|226480
NC_018581.1\|WP_014928744.1\|912065_912464_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_018581.1\|WP_148281250.1\|896337_897150_-\|esterase-family-protein	gnl\|CDD\|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	4.8589e-42
NC_018581.1\|WP_014928743.1\|903890_904796_+\|acetaldehyde-dehydrogenase-(acetylating)	gnl\|CDD\|236227	PRK08300, PRK08300, acetaldehyde dehydrogenase; Validated.	0
NC_018581.1\|WP_044507604.1\|906949_908098_+\|TDT-family-transporter	gnl\|CDD\|187760	cd09320, TDT_like_2, The Tellurite-resistance/Dicarboxylate Transporter (TDT) family. The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).	2.16637e-88
NC_018581.1\|WP_010842127.1\|915186_916098_+\|VOC-family-protein	gnl\|CDD\|132257	TIGR03213, Biphenyl-23-diol_12-dioxygenase_1, 2,3-dihydroxybiphenyl 1,2-dioxygenase. Members of this protein family all have activity as 2,3-dihydroxybiphenyl 1,2-dioxygenase, the third enzyme of a pathway for biphenyl degradation. Many of the extradiol ring-cleaving dioxygenases, to which these proteins belong, act on a range of related substrates. Note that some members of this family may be found operons for toluene or naphthalene degradation, where other activities of the same enzyme may be more significant; the trusted cutoff for this model is set relatively high to exclude most such instances. [Energy metabolism, Other].	2.13723e-104
NC_018581.1\|WP_014925472.1\|908211_909759_-\|MFS-transporter	gnl\|CDD\|365860	pfam00083, Sugar_tr, Sugar (and other) transporter.	7.68899e-50
NC_018581.1\|WP_014925467.1\|900968_902111_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.49346e-83
NC_018581.1\|WP_014925469.1\|904792_905887_+\|4-hydroxy-2-oxovalerate-aldolase	gnl\|CDD\|181282	PRK08195, PRK08195, 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated.	0
NC_018581.1\|WP_044505903.1\|899910_900972_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	1.39015e-23
NC_018581.1\|WP_014925468.1\|902107_902920_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|180298	PRK05870, PRK05870, enoyl-CoA hydratase; Provisional.	3.372e-48
NC_018581.1\|WP_010842128.1\|913955_915140_+\|flavin-dependent-monooxygenase	gnl\|CDD\|173848	cd01159, NcnH, Naphthocyclinone hydroxylase. Naphthocyclinone is an aromatic polyketide and an antibiotic, which is active against Gram-positive bacteria. Polyketides are secondary metabolites, which have important biological functions such as antitumor, immunosupressive or antibiotic activities. NcnH is a hydroxylase involved in the biosynthesis of naphthocyclinone and possibly other polyketides.	2.1917e-153
NC_018581.1\|WP_014925473.1\|909939_910734_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	2.67067e-29
NC_018581.1\|WP_014928745.1\|912490_913729_-\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	gnl\|CDD\|239607	cd03531, Rieske_RO_Alpha_KSH, The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway, catalyzing the 9 alpha-hydroxylation of 4-androstene-3,17-dione (AD) and 1,4-androstadiene-3,17-dione (ADD). KSH is a two-component class IA monooxygenase, with terminal oxygenase (KshA) and oxygenase reductase (KshB) components. KSH activity has been found in many actino- and proteo- bacterial genera including Rhodococcus, Nocardia, Arthrobacter, Mycobacterium, and Burkholderia.	1.50365e-71
NC_018581.1\|WP_014925463.1\|897305_897716_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	2.54329e-09
NC_018581.1\|WP_044505901.1\|897717_899064_-\|glycosyl-transferase	gnl\|CDD\|224732	COG1819, COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms].	7.17294e-44
NC_018581.1\|WP_014925465.1\|899259_899883_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.0485e-09
NC_018581.1\|WP_044505908.1\|911414_911942_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	7.75029e-23
NC_018581.1\|WP_014928742.1\|903065_903854_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|226480	COG3971, COG3971, 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism].	1.77612e-95
NC_018581.1\|WP_010842126.1\|916099_916702_+\|flavin-reductase-family-protein	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	2.8038e-54

>NC_018581.1|WP_014925469.1|904792_905887_+|4-hydroxy-2-oxovalerate-aldolase
MSTNVVLTPRDPKLMANARKYSDTLDIRITDSSLRDGSHHKRHQFTEDEVRAIVGALDEAGVPVIEVTHGDGLGGSSFNYGFSKTPEQQLIKAAAETAKRAKIAFLMLPGLGTKDDIRAAQDNGGQICRIATHCTEADVSIQHFGLARDLGLETVGFLMMSHSQPPEVIAKQARIMADAGCQCVYVVDSAGALVLEDVTVRVEALVAELGNDAQVGFHGHENLDIAVANSVNAIRAGAQQIDGSIRRFGAGAGNTPTEAFVGVCDKLGITTGVDFMKIADAAQDVVRPAMPSECLVDRSAMMMGYAGCYSSFLKHAEGHAERYGVSAAEILLEAGSRKLVGGQEDQLIDIALELKKKQDANAGV
>NC_018581.1|WP_014928743.1|903890_904796_+|acetaldehyde-dehydrogenase-(acetylating)
MAAKLTAAIIGSGNIGTDLMYKLERSEVIEPRWMVGIDAASEGMKRAADHGLITMSGGADELLASSERPDLIFEATSAYVHREYAPKYEEAGIVAVDLTPAAVGPAVVPPANLREHLDAPNTNMITCGGQATIPMVHAVSSVVPVPYAEIVASVASVSAGPGTRANIDEFTATTSKGVETIGGAQRGKAIIILNPADPPMIMRDTIFCAIPEDADTDAIAESIHRREKEIQAYVPGYRLLQDPQFDPPSVLNGGHARVSIFVEVEGAGDFLPPYAGNLDIMTAAATKVGEEIAKTKLGVPA
>NC_018581.1|WP_014928742.1|903065_903854_+|fumarylacetoacetate-hydrolase-family-protein
MAVEQGIREQIAADLARAEASATAIDRPTDAHPDLDVVDAYEIQLINIRKRLGAGAKVAGHKVGLASEAMQKMMGVDEPDYGHLLDDMQYFEHTPIDAKKLCFPRVEVEVGFILGEDLPGEGCTNEDVIDAVAWVVPSIELIDSRIKDWKITLCDTIADNASSCGWILGQQRVPISEIDTGDIEATLTRNGEIVAKGNSSAVLGHPLNAVSWLARKVEGFGVRLRKGDVILPGTATRAIDISSGDHFVAEFAGLGSVTLDFI
>NC_018581.1|WP_014925468.1|902107_902920_-|enoyl-CoA-hydratase/isomerase-family-protein
MSSESPNPVSPDDDTGEAILTSVNDGVGRLTLNNPRRKNAITLEMAAAIERFCDRVIDDDNVGAVVVDAVGSYFCSGADTRILAAASADPAAPSSVAQLSAVYRAFVRVGSLPVPTVGVVVGGAVGAGLNLALAVDLLVTTPDAVLDSGFLARGIHPGGGHLALLNRAVGRANTIALAACGQSLSGEQAVERGLAYAAAPVPDIPAIVDGLTGPAARDPELTRRVMASVRMELGPPAVTWDSAIEIERGTQMWSMARKGQNWSSRGPGRS
>NC_018581.1|WP_014925467.1|900968_902111_-|acyl-CoA-dehydrogenase-family-protein
MSRGAVADDVLHALRDEVRTFLRTELADGAFRPDVDSWMTGFDPDFSRRLGERGWLGLTMPVEYGGQGRTAVERFVVTEELLAHGAPVAAHWIADRQMAPSILANGTETQKRRYIPGISSGTVFFAIGMSEPDAGSDLASVRTRATGNGDTWSLRGTKVWTTGAHIAHAMVLLARTDGSTEDRREGLSQFVVDLPHPDIEIRPLASIDGEAHFNEVIFHDAVVDSSALLGVRGQGWRQVMSELAFERSGPERYLSTLPLLRAWTGLLREHGATPEQRRTLGELTAQAWALRQMSLQVARELHAGGEPDVLAAMVKDLGSTFEGDLVSAIRDASGAIPRRTGGTDFERMLAQAVLHTPAFTLRGGTNEILRGIIARGLGMR
>NC_018581.1|WP_044505903.1|899910_900972_-|acyl-CoA/acyl-ACP-dehydrogenase
MSDLATELAAATAAMLARFPVDLRTPGAESGTELWAALLDAGFTSVDVPEEAGGQGADLADALAVLDALAGAGALTPYAEHALLAAWLAGNVGHSLDGATATVAVVDDATVDRDGERVRLSGDAVGVAHLATAEVVVALAGTPDGPVIAVCRCDCPGVRLDSGTDLSGMSFGDIDFEGVEADFAAASPITVDDLRTRGALVYAVALAAAARAVRERTVRYAAERVQFGRPLAKFQAIQQTLARMAAQTTLMETAARAATDAASGDAVTARNAIAAAKIVTSRHAHEVAAAAHQIHGAIGFTAEHALGRFTTALWGWSDRYGDDHEWANVLAERILDGGVDSWDVIVGGRDGNA
>NC_018581.1|WP_014925465.1|899259_899883_+|TetR/AcrR-family-transcriptional-regulator
MSRRPYTPRKRAISAAHTRSRILDAAQELFVAQGYSRTTLQQIADRAGVAVGTVHQAGSKASLMMAVLERGFTGDEKFVSLLERPEFIAIMEEADTARAIDRYLDHILAANSRIADLWHAATLAADSDPTIGEQLERSELRRLDDVHTGSHWFVHRNLIEDTEVDEFADILSHLTSPATYRYFTVERGWTPARLKKWMIVSIEAAMR
>NC_018581.1|WP_044505901.1|897717_899064_-|glycosyl-transferase
MSTYLMCSTPLAGHVGPVIAVGSTLVDRGHTVIVVTGSRFTDQVAAAGMIPHPLDGTADLDERDPDSFTPDRDRYRGLALSRYQVQCTFIDPLADQARAVDSALGVHDVDAVLCDGTFAGIIPLLSRPASRRPPVLGLGTMPLAQTSPHVAPFNSGLRPMGGPAGRIRNRLAHLMVRHVLFASTQRRARELARGAGGSLDHFVLDLSRAFDRFVQLGPAEFEYPRPDLPADTVFAGPVLDRHAHPPDDARTMSPWWSELLDDDRPIVHVTQGTLDNHDFSQLVEPTLTGLADMDVRVVVSTGGADPRSVIPSGNATISQYLDYDALLPRTSVMITNGGYGGVLHALSHSVPVVVAPGGEDKPEVAARVRHFGVGVDLGTRRPSPRQISDAVASVLADDELAGRCARMARAIADYDPARIVSTQLDDLTTANSHQTIPTTRPTTPQEEH
>NC_018581.1|WP_014925463.1|897305_897716_-|nuclear-transport-factor-2-family-protein
MTDARTVIDAHIDAFNTREPANEPWSSDAELIAPGGSFAGRDQVLGFLSVFQGAFPDGRLSVHSYVIDAEHASVEGVFAGVHDGVLQSPQGAVDPTGRSVTFRWSATYGVRGSELVSEHLYFDQLDFLGQLGLLPG
>NC_018581.1|WP_148281250.1|896337_897150_-|esterase-family-protein
MGRDVPVTVLHPAHRGPRGTLYLLDGGGHKGTVSDWITEARVDRYFRDKTVNVVMPSGQGAFYTNWNRADPRFGRPQWETFLTRELPPLVDRLFHGTGRNAIAGLSAGGQAAFTLATRRPAIYTGVGSISGCPPTTGPVNESQIRAAVIRDGGDPTNIWGAWNGPGWADHDPARRLSALQGKHIFIAAGTGAPSPLDRLTRLDPGRSRLEKITTGAVLESLVNTCSRDFVARMRAAGLRPATHFRPVGTHAWPYWARDIPVLYSALSPGL
>NC_018581.1|WP_044507604.1|906949_908098_+|TDT-family-transporter
MTTTTLTAGLAEKDRGPATDTGTKRRHVSYVPPNWFAAVMGTGIVAIAAHSLPWQPPGLAVVATVFWLLACAVFAGVVAATVRHWVRDPEIARGHHAHRVVAHFYGAVPMAVMTVGTSTMVVGTTVIGRDLALGIDVVCWIIGTIGGVFTAVVIPYRHLIVGRPAVGEAFGGWLMPVVPPMVSASAAAVLTPQLPAGWASEVVMVIGCAMFVLAALASLPILAVLAARLRSGDVGAAHMVPTWWIVLGPLGQSITAACLLAHVAPHVVGAPIVGTLQSFAMGYGLTVWVVATLWIVVAARLTVRTLRSGMPFAMTWWSFTFPLGTYVTGSSALALTLGGAVFQVTAVAGFAVLVLAWGVVAVRTVRGVVTGELLRVPLLPVR
>NC_018581.1|WP_014925472.1|908211_909759_-|MFS-transporter
MSATESGALPDTVQSYLDEVPAWRDGTPATAGAMTSMQRRIWLLASAGKFLEGMIVFMVGVALPLIIDDFGLGSAQSGVVTAAPLLGIMIGASALGGLSDRWGRRQLFLAEMVLFTAFLVGVTFSTGFPMLVVCLVGMGMALGCDYPTAHTMISETMPTSIRGRGVLAAFGFQAVGALAGTLVGVIILGNRDELSDWRWMFGVVVVPSVLVIVGRLFIVQSPHWLLGTGRVDEAERALKRLLTRRPQYPSTVSLALRDESASGPDSADGSPSNIGSLFRRPWRRSTILASIPWFLQDLGTYGIGIFTPTIIAATIGTAAADDATVSGVVADDLHGAEGAVLIDAFLLIGIALAILLVNRLGRIRLQVFGFLGCAVGLVTAAASTLLDGTLQVVLVFVGFMLFNLMTNLGPNSMTYLLAGEVFPTSLRGTGAGLAASVAKVGAVLTAFLFPVLLDAWGTAIIVLLLAGTSALGAFVTWTFRVETTGLSLEDVDRMHDAPSPTGGMSTPRPTPAGIS
>NC_018581.1|WP_014925473.1|909939_910734_-|VOC-family-protein
MAEYAAPSGAPIWFDLMSSDTAKAEEFYGAIFGWEAEAPDEEFGGYRNLLKNGKRVAGLSPVMEGAGPPDIWTVYLHAEDADATVKAVEAAGGSIMVPPMAIGEEGTMLMALDTAGAAIGFWQPDKHNGYSEFGDHGTPYWFECQSMDYAKSVDFYRTVLGARIEEIGTGGDPDAVGPDNYAQIFYGETSYAGIMDSVKLFPAGVPSFWQIYITVDDVAATVKQAESLGAEILMAGEDTPYGTLAAIKDPMGALICLGHPPAGM
>NC_018581.1|WP_044505906.1|910888_911440_+|hypothetical-protein
MTTHSATVERLRTAAWPVLLAGGLLLVLLAQVQWGWTDEGVEPSITGLGHVKILGASDDDVAFFFEDKTDRPGLSVVVAGAVIAVVAALGWWRARLRPSAIGVIGLASIVALVVGVRVLSDPAAQLFSDSVSEALGADLPAMRAGYGLIGTVVVAALLLVVVVGWVLTTWWPRPTLSRTDESS
>NC_018581.1|WP_044505908.1|911414_911942_-|C40-family-peptidase
MSVSPPRFRRVTCTIALTAALSVGVPLIGPPLLDTGRAAAAGSSDSSGSVPIYLPVPTTVGLNALGAAITQIGKPYKWAGVGPHSWDCSGLVRWAFYTTGVHLPRTSQQQAKVGHAIPFRALAPGDIIIFGRDAGHVGIYAGAGRVFNAYGPNGVPIGFTKLKDMGYIKTIRRFG
>NC_018581.1|WP_014928744.1|912065_912464_-|hypothetical-protein
MGSDRWAKAPDFHDDPDRLARVHEATRRDREHYLQGGMREIECRACHACVLVKKTSSFHTSVQWNADARERCLGLEQMRAGGDGGNGDTGNGPLLPGAMMPTCARLSASIDHGVSEGIIPAESPVSDPDGYW
>NC_018581.1|WP_014928745.1|912490_913729_-|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha
MSSGPETMTPSSPGTPSAAAASDGADVGIREIDTGAPPTRFARGWHCLGLLEEFSDGKPHSVTIFGTKLVAWVDTKGEVNVLDAFCRHMGGDLSQGKVSGDNVACPFHGWLWKGNGRCAGVPYAKRNPKLAKTRSWPSMVRNGQVFVYNDPEGNPPPDECIIPELDEFGSEEWTPWTWNRIVIEGANCREIIDNVVDMAHFYYVHFALPDYFKNVFEGEMAAQYMNSHGRPDVTLGTNYGDSRLESIAAYYGPSYMLNPMIQYYGGYAVETILTNCHYPIDENSFVLMYGVMAKVPDGLTAEQASKMATKISAGVEVGFLQDVEIWKNKTRIDNPLLVEEDGPVYQLRRWYDQFYVDKADVTDEMTGRFEYEIDTSKALESWNEEIQENLRRQEAEKAESAAGSESTEKAEV
>NC_018581.1|WP_010842128.1|913955_915140_+|flavin-dependent-monooxygenase
MPAQRSEAAEQVLEKINVLLPELEQRAQSTEDLRRIPDETVSSLETAGFFRLLQPEQWGGYEADPVTFYEAVRRIASACGSTGWVSGIIGVHNWHLALFDQQAQEDVWGSDTNVRISSSYAPMGMGEVVDGGYKVNGSWAWSSGCETADWVFVGGPVIKNGKPVDFVSFLIPREDYTIRDVWNVVGLRGTGSNTIEVKDVFVPRHRMLSMRTMSMGQSPGLERNTAPVYKMPWGTIHPSTIATPIVGMAYGAYRAHVEHQGKRVRAAYAGEKAKEDPFAKVRIAEAASDIDAAWRQLSGNLQAEYDLILAGEEIPMELRLSARRDQVRATGRAIAAIDRLFENSGAHALENGTPIQRFWRDAHAGRVHAANDPERAYVAFGNGEFGIPIGDTMV
>NC_018581.1|WP_010842127.1|915186_916098_+|VOC-family-protein
MSDSPIRSLGYMRIEATDIEAWRTYGLKVLGMIEGSGLTDGALYLRMDDFPARLVIVPSEHDRLASAGWEVANAAELQNVRDRLARAGVVFREGKDEEIADRRVAEMIVFDDPADNTLEVFHGAALEHRRVVSPYGHRFVTEEQGLGHVVLTCSDDKAALEFYRDVLGFRLRDSMRLPPQVVGREEGDEVPWLRFLGCNPRHHSLAFLPIPNSTGIVHLMVEVENADDVGLCLDRALRKKVPMSATLGRHVNDLMLSFYMKTPGGFDVEFGCEGRTVSDDEWIARESTAVSLWGHDFSVGFKG
>NC_018581.1|WP_010842126.1|916099_916702_+|flavin-reductase-family-protein
MPPDATTQQSHARSPYGSADFDSRQFRTAMGQFCTGVTVITTLDDAGNPVGFACQSFAALSLDPPLVLFCPMKTSRSWKVIEKTGKFCVNVLSNRQQDVSAAFGAPGDDKFANITWDPSPAGLPVIRHALTWVECDVDSVTDGGDHHIVIGRALTLGEVLQDKPLLFYRGGYLSTEHPRVTPAQAELENFLTWTGGDTWL

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Crispr_ID: NC_018581_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018581_3

1023343-1023441

Orphan

Consensus_repeat	Method
CGAGCCCGACGCCCCGGAACCCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018581_3

>merge|NC_018581|3|1023343-1023441|CRISPRCasFinder
CGATCCGCCCGCCTCCGAGCCCGACGCCCCGGAACCCGACGCCCCGGACTCCGACGTTGCGGACCCGGAAGTAGTCGAACCCGACGCCCCGGAACCCGA

>NC_018581|3|3|1023343-1023441|CRISPRCasFinder
CGATCCGCCCGCCTCCGAGCCCGA	CGCCCCGGAACCCGACGCCCCGGACTCCGACGTTGCGGACCCGGAAGTAGT
CGAACCCGACGCCCCGGAACCCGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_018581.1\|WP_044505973.1\|1031065_1032538_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143421
NC_018581.1\|WP_044505971.1\|1023966_1024671_-\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014925549.1\|1024763_1025678_-\|manganese-catalase-family-protein	unknown	unknown	gnl\|CDD\|252986
NC_018581.1\|WP_010842019.1\|1035026_1035653_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_018581.1\|WP_044505969.1\|1022903_1023338_+\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014925547.1\|1022034_1022907_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185594
NC_018581.1\|WP_010842035.1\|1016059_1016848_+\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|235486
NC_018581.1\|WP_014925551.1\|1028154_1028850_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NC_018581.1\|WP_014925552.1\|1029019_1030183_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NC_018581.1\|WP_014925546.1\|1021009_1021987_+\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450
NC_018581.1\|WP_044505964.1\|1012731_1014393_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155
NC_018581.1\|WP_083889016.1\|1032672_1033593_+\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238861
NC_018581.1\|WP_014925556.1\|1033677_1035027_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NC_018581.1\|WP_010842033.1\|1018220_1019165_+\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612
NC_018581.1\|WP_010842032.1\|1019214_1020891_+\|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|376850
NC_018581.1\|WP_014925553.1\|1030334_1030937_-\|YdcF-family-protein	unknown	unknown	gnl\|CDD\|99750
NC_018581.1\|WP_014925550.1\|1025911_1027996_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173839
NC_018581.1\|WP_044505967.1\|1015653_1015908_+\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|368604
NC_018581.1\|WP_010842037.1\|1014429_1015557_-\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|273654
NC_018581.1\|WP_010842034.1\|1016844_1018224_+\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592

Protein	Function_ID	Function_description	E-value
NC_018581.1\|WP_044505973.1\|1031065_1032538_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	0
NC_018581.1\|WP_014925549.1\|1024763_1025678_-\|manganese-catalase-family-protein	gnl\|CDD\|252986	pfam05067, Mn_catalase, Manganese containing catalase. Catalases are important antioxidant metalloenzymes that catalyze disproportionation of hydrogen peroxide, forming dioxygen and water. Two families of catalases are known, one having a heme cofactor, and this family that is a structurally distinct family containing non-heme manganese.	3.60102e-92
NC_018581.1\|WP_010842019.1\|1035026_1035653_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	2.22511e-39
NC_018581.1\|WP_014925547.1\|1022034_1022907_+\|hypothetical-protein	gnl\|CDD\|185594	PTZ00395, PTZ00395, Sec24-related protein; Provisional.	1.04773e-07
NC_018581.1\|WP_010842035.1\|1016059_1016848_+\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|235486	PRK05472, PRK05472, redox-sensing transcriptional repressor Rex; Provisional.	2.63671e-76
NC_018581.1\|WP_014925551.1\|1028154_1028850_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	2.67216e-15
NC_018581.1\|WP_014925552.1\|1029019_1030183_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
NC_018581.1\|WP_014925550.1\|1025911_1027996_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173839	cd01150, AXO, Peroxisomal acyl-CoA oxidase. Peroxisomal acyl-CoA oxidases (AXO) catalyze the first set in the peroxisomal fatty acid beta-oxidation, the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. In a second oxidative half-reaction, the reduced FAD is reoxidized by molecular oxygen. AXO is generally a homodimer, but it has been reported to form a different type of oligomer in yeast. There are several subtypes of AXO's, based on substrate specificity. Palmitoyl-CoA oxidase acts on straight-chain fatty acids and prostanoids; whereas, the closely related Trihydroxycoprostanoly-CoA oxidase has the greatest activity for 2-methyl branched side chains of bile precursors. Pristanoyl-CoA oxidase, acts on 2-methyl branched fatty acids. AXO has an additional domain, C-terminal to the region with similarity to acyl-CoA dehydrogenases, which is included in this alignment.	2.22083e-176
NC_018581.1\|WP_044505964.1\|1012731_1014393_+\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	9.17842e-24
NC_018581.1\|WP_083889016.1\|1032672_1033593_+\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238861	cd01823, SEST_like, SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.	5.2092e-55
NC_018581.1\|WP_014925556.1\|1033677_1035027_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NC_018581.1\|WP_010842034.1\|1016844_1018224_+\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	1.66728e-162
NC_018581.1\|WP_010842032.1\|1019214_1020891_+\|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase	gnl\|CDD\|376850	pfam02602, HEM4, Uroporphyrinogen-III synthase HemD. This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as HemD with pfam00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease.	1.67933e-63
NC_018581.1\|WP_014925553.1\|1030334_1030937_-\|YdcF-family-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	3.0686e-29
NC_018581.1\|WP_014925546.1\|1021009_1021987_+\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NC_018581.1\|WP_044505967.1\|1015653_1015908_+\|glutaredoxin-family-protein	gnl\|CDD\|368604	pfam05768, DUF836, Glutaredoxin-like domain (DUF836). These proteins are related to the pfam00462 family.	1.04352e-11
NC_018581.1\|WP_010842037.1\|1014429_1015557_-\|HAD-IB-family-hydrolase	gnl\|CDD\|273654	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490. This hypothetical equivalog is a member of the IB subfamily (TIGR01488) of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The sequences modelled here are all bacterial. The IB subfamily includes the enzyme phosphoserine phosphatase (TIGR00338). Due to this relationship, several of these sequences have been annotated as "phosphoserine phosphatase related proteins," or "Phosphoserine phosphatase-family enzymes." There is presently no evidence that any of the enzymes in this model possess PSPase activity. OMNI\|NTL01ML1250 is annotated as a "possible transferase," however this is due to the C-terminal domain found on this sequence which is homologous to a group of glycerol-phosphate acyltransferases (between trusted and noise to TIGR00530). A subset of these sequences including OMNI\|CC1962, the Caulobacter crescentus CicA protein cluster together and may represent a separate equivalog. [Unknown function, Enzymes of unknown specificity].	2.85205e-58
NC_018581.1\|WP_010842033.1\|1018220_1019165_+\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	9.4098e-134

>NC_018581.1|WP_044505969.1|1022903_1023338_+|hypothetical-protein
MTSPDPALRPKLVVWAYRCWLASGALLVALGALVIVVSAVADTGTVTSGVLGAMVVVVGVAYILLGSKAYTGDVRWRSSLAALTLVVVAMLLFLSLGIQFFAFPLLAAIVGLFGSLLAYRPPAETWYTGKEPDAPARRSRKKNT
>NC_018581.1|WP_014925547.1|1022034_1022907_+|hypothetical-protein
MPEPYGPAPESDPGASSRPKIPDSVSIAVELWVVVIVGQIVALFAQTGTFVDMIRDQVRAAPQEGVPPEQVDFMTSSGFVIGVLVVTSLFLTAITALVVWFTRKGYNWARVVLSAMGVYVVVSLLFSLFGDTSPVWAMIPQVISGVAALGATVLLMRGDSETYCRAMAQARKPQPVHPPTPPYPYGQNPYGQNPYGQNLYGQNPYSQNPYERNPYGQNPYGQNPYGRSPYDPNPHGENTPYGDSEHRDERVGPHPEKPHSEPVHLEKPRPENLRPENSGSENQNEGPKNQ
>NC_018581.1|WP_014925546.1|1021009_1021987_+|porphobilinogen-synthase
MPPVIRPRRLRTTPAMRRLVAETSLEPRHLVLPMFVADGIAEPVPISSMPGVVQHTMESLRGAAAEAVAAGVGGLMLFGVPRPEDKDATGSGADAEDGILNRALRTLADDLGDATVLMADTCLDEFTDHGHCGVVDDRGRVDNDETLERYVSMSLAQARAGAHLLGPSGMMDGQVATIRAALDAEGFTDTGILAYAAKYASAFYGPFREAVGSSLQGDRRTYQQDAANRVEALREVRLDLEEGADIVMVKPAMSYLDIVRDVADMSDVPVAAYQISGEYSMISAAAERGWIDRDAAILESLTSIRRAGASIVLTYWAAEVAQRLS
>NC_018581.1|WP_010842032.1|1019214_1020891_+|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase
MSRTKKANPGRILFVGSGPGDPDLLTVRARTVITNATTAYIDPDVPAPVVSLIGSAHRDEPDVDTRRSAKKAEKPADDATSTPASPPDEPQAVEGDAGQADEESVVRPALGDPAEVAKTLVAAARNGDDVVRVVSGDPLTTDSVLAEVNAVARTSVTFEVLPGLPAASVVPSYAGMPLGSTHTEADVRGEVDWAALAAAPGPLVLHATSGHLAETASALTEHGMAPQTPAAITINGTTCAQRTIEATLATLNEQGNALTGPLIVTVGKVVGARGKLSWWESRALYGWTVLVPRTKDQAGDMSERLVSHGAMPKEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEKFAEFGLDARAFSGVKIACVGEATAEKVRSFGINPELVPSGEQSSLGLLEEFPPYDDVFDPVNRILLPRADIATETLSEGLRDRGWEIDDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETATEFGLRVDVQPENASVIELVDALAEHAARLRAEGALPPPRKKSRRSRS
>NC_018581.1|WP_010842033.1|1018220_1019165_+|hydroxymethylbilane-synthase
MSATSPAPIRIGTRGSLLATTQSQTIADALTAAGHPAELVIIKTAGDASAAPVAEIGVGVFTTAIRVALRNNEVDVAVHSYKDLPTAPEDDLTIAAVPTRVDPRDALVARDGLVLGELPPGSVIGTSAPRRAAQLKALGLGLEIRPLRGNLDSRLGKVASGELDAVVVARAGLVRIGRTEVVSEALEPVVMLPAPAQGALAVECRSDDAELVRILAELDDKSTRAAIDAERAVLAALEAGCTAPVGAIAEVVESIDEDGRIFAELSLRAAVAAEDGSDVIRASVVGPVDRAVQLGKDLAAELLELGAGDLVNSP
>NC_018581.1|WP_010842034.1|1016844_1018224_+|glutamyl-tRNA-reductase
MSVLLFGVSHRSAPVEVLERLAVSDHDRPKLIDELLSSRAISEAMLVSTCNRVEIYAVVDAFHPALEAVGAVLGDHSGMTVNEMTRHAYVRYSEAAVEHLFTVAAGLDSLVVGEQQILGQIRNAYLSADANDSAGRVLHELAQQALRVGKRVHTETGIDRAGASVVSVALHRAKSLLTDPATGAHRLRRAVVVGAGAMGGLATAQLAREGVTEMVVVNRTVEKADHLAGNIAANHGISVRGVGLDDLPAAMATADVVVTCTGAIGAVVGVGSVHSALASRAGDAAPLVICDLGLPRNVDPAAARLPGVHIVDIEGLRGDSETQAAENDTLAARSIVAAELADYLTHQRQAEVTPTVAALRQRAADVVEAEILRLETRLPDLEGAQRDEVAKTVRRVVDKLLHAPTVRVKQLASTPNGDHYAEALRELFELKPGAAEAVSAPDHLGGLPAGDAAGELGDR
>NC_018581.1|WP_010842035.1|1016059_1016848_+|redox-sensing-transcriptional-repressor-Rex
MGAERAKSADADPPASVVPAPDIPAADIPGPTVARLATYLHVLRSFSRRGVLVASSGELATAAGVNPAILRKDLSYVGANGVRGVGYDVGRLTARISMTLHTDSIHTVALAGAGSLGRALLSHAGFGRGFRVVAMFDADPALTGTVLEAGGPRVAPLTDIADVCQRAVPTVEIAVIATADDDARNAFDAFVAAGVRQVLNVTPVSLPAESDVVVRQVDLALELQVLAFQASRGSRDDVKEPRGTKPARRHQGNAMGEETVTA
>NC_018581.1|WP_044505967.1|1015653_1015908_+|glutaredoxin-family-protein
MTVELLTRAGCQACAAARSDLTRICAELGVGFSEVDVDLAADEGRADLRAEFGDRLPVVLLDGDEHSYWEVDEPRLRADLTGRR
>NC_018581.1|WP_010842037.1|1014429_1015557_-|HAD-IB-family-hydrolase
MGEIPGPEDRQDDQTPEDATILPPNPMQGDGPTGDDWEAHAARVEFTDDFDEDAELHELVDDETNRVTNWISQRATAATGRFRQTAHELRQTLAGEASAKAAVDSLRSRETADIPGEPRRDLTAAAFFDVDNTLVQGASIVHFARGLAARKYFTYGDIMDFAWTQAKFRITGKENARDVAEGREKALSFIAGKPTAELVELGEEIFDDYIADKIWPGTRALAQRHLDAGQQVWLVTATPVELAQTIADRLGLTGALGTVAESVDGVFTGRLVGDILHGPGKAHAVRALAIREGLNLKRCTAYSDSHNDVPMLSLVGRAVAINPDTDLRDVAKVRGWEMYDFRTARKAAKYGAGTAIVLGAAGGGAAAAARFLRQR
>NC_018581.1|WP_044505964.1|1012731_1014393_+|HNH-endonuclease
MWTDLPGEFVAGVDPARAAETDMVMLMAGLDATRRGESYLAWHRYQTIAAMTDRLVTTSASGFVMDGHADCAARIARQAAVSRRRAEILIDEAIALRDRLPDTADTLRDGVLSQWQIRLILSRTELIPADDPVIPALDAEIADTLRRRSGVWDRARLRDMVDRLVFRHDPDAVRQRRKDAMDQRGVWTHELPDGTAELTAVMSAENVRISAKAVSVLADAVCKRDGRKRGHRQSDAMFALLTRTAFECQCADDEPCTADIPDPQGVLEAVRAEIVIHVVTDAATLAGAPGVGFLDEHGIISDEHVRDLAARPDATLSPVTPARTQPTYVATNDDDHRRTAQHPAPAEDTRADDDNGGATTRSDGEPGDTTASVAVVYPATHPGNGYRPTASCADFVRVRDGYCTEPGCTRSAFACDLDHVTEYDHTDPARGGATSSENLNAKCRPSHLLKTHGDWVDVQYRDEDGRLVTEYETPEGVTLPGDAETLEDTFPNLRRIRFEQAAQAPPTPHVIASADNRERAPSRLDAKLARRRHERARNKRAREELDRLDPPPF
>NC_018581.1|WP_044505971.1|1023966_1024671_-|hypothetical-protein
MSALPDLITTPFRWLGALRHARVFHPDGLLCGGHAALSADHPLPFRSGPVSVRVSKGIGTPGALPDIVGVAIRFPASDPGTVGGGGVSPSTNATGAWDLLLAGPAPLAGRLPVPLPTTHWATAVSSLTPYRYDGRLYWIRARILEPSDSSGVSIEDLAARLRRNQPIVIVLEAGARRFVPVVRIELDHVLTGLDVDFDPILHRPEGVEFAPSWLGDLRRRAYRDSRAGRHSVTS
>NC_018581.1|WP_014925549.1|1024763_1025678_-|manganese-catalase-family-protein
MFRHTDYMQFDVKPEKPDPIYARKLQELLGGAYGEMTVTMQYLMQGWNCRMKGKYKDMIMDIATEEIGHVEMIATMVARLLEGAPVTNSTENALGDPVVAAVLGGTDPTQAIFSGGGPRLADSNGVPWNSGYITHSGNLLADFHANVTAEAQGRVQTARLWHMTDDPGVKAMLRFNLARDTFHQNLWLKGIEELKEDGLEGTIAPDDLFDEEFSEHASTLWHLSDGEDSNKGGWASGPTPDGAHEFKFLADPQPLGDRQSGPPPDPKLYATYDGAMGTPQKPQFGTEKGVIGKIKDAVDPDPSG
>NC_018581.1|WP_014925550.1|1025911_1027996_-|acyl-CoA-dehydrogenase-family-protein
MATPTSASPDEQAPAAKTPSTTSPTPIATEPTVDDPVTPASVSADDELSADERALLVDNLRFVLDGRWRTTRETVRENSNRADLLPDPSRTLDEARAHTLEVMRELASQGFAAAGFAEDHGGSGDIGASITAIEMLGYADLSLMVKAGVQWGLFGGAVENLGTARHHEKYVPGIIDLSVLGCFAMTEAGHGSNVQAIETTATYDRDAREFVINSPTPSSRKDYIGGAAAHARYAAVFAQLVTGGPDEEAEGRGVHCFVVPIRDEDGNDLPGVTTSDCGYKGGLAGVDNGRIMFDNVRIPAENLLNRYADVAADGSYSSPIENTNRRFFTMLGTLIRGRVSVAATAGAAGRKALALATRYGLIRKQFEAPDATDEITVMDYLGHQRKLLPLIAKSYAIGFAQNEIIAELHEVQSVAPDDSDAGRQRQLEGQAAGLKAYATWHASHAINVSREACGGAGYLDENQLSIMRGDIDVFTTFEGDNTIMTQLIAKELLSAYSEDVQGLSAGGWVRFIAGMARDVVAEKTAVRQVVQTLLDGSDEDTEKSALTDRSTQIRLFRNREDHLVRTCAQRLRRALDDDNDAFEVFNNAQDHLLQVGHAHIERVVLEAFVEAIENCDSRSAADLLGKVCDLFVYSALEDDLSWFLMHRHISVERAKAIRRGVNELCLELRPHARSLVDAFGVPEELLRAPMLQNG
>NC_018581.1|WP_014925551.1|1028154_1028850_+|TetR-family-transcriptional-regulator
MSAADSDPAAFRTRVVAESIRLFSEHGYESTTVEQLAAAAGMSRRTFFRQFGSKEDVIFADHESLLAQVGARLAADRGDPWLAVCAAAELVFGHFVRDRELAVRRAQVVQEVPALRDRELVTTYRYQGAFEEFLRTRLPDESPVHVVAYVAAVTGTHNFLLRQMIRGDAEATPERLRVELERVAVALGAGRAGEASTRRATPGRQVTVVTYPTGTSPAEVARRVAEELGEG
>NC_018581.1|WP_014925552.1|1029019_1030183_+|acyl-CoA-dehydrogenase
MGYGNPDFNVFELPEEHIALREAIRALSEKEIEPYAADVDENSRFPQEALDALVASGFNAIHVPEEFGGQGGDSIAACIVIEEVARVDASSSLIPAVNKLGTMGLILNGSDDLKQQVLPGIASGEAMASYALSEREAGSDAAGMKTRARKDGNNWVLNGTKCWITNGGKSSWYTVMAVTDPEKKANGISAFMVHKDDPGFTVGPLEKKLGIKGSPTAELYFEDCTIPLDRIIGDEGTGFKTALQTLDHTRPTIGAQAVGIAQGALDQAIAYVKDRKQFGKPISSFQGVEFMIADMAMKVEAARLMVYTSAARAERGEKNLGFISSASKCFASDVAMEVTTDAVQLFGGAGYTRDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLR
>NC_018581.1|WP_014925553.1|1030334_1030937_-|YdcF-family-protein
MRRRNLTTAAAAAAIATAASVAVAVAPSEPAANVQNAAISTDFGSVDLGSSELGTPNSNFLWQSPPTRYIVVLGAKFGVLGQTPDVLKRRLDVAANLGKKHPFNRMIVSGGDTHWLPVTEAQFMNLGLIRRGIPMWQMVNEGASTSTVQNAQNTVRMLKHMGANGAIIVTNGFHMERAMKNFRDAARQQGARIEFRSAYA
>NC_018581.1|WP_044505973.1|1031065_1032538_-|NAD-dependent-succinate-semialdehyde-dehydrogenase
MSGDKNVLDPRGVLEAVPTGLWIDGRSTPAADGTTFDVYDAATEESLVSVADAGVADARAALDSAVAASADWAATAPRERGEILRRTFELLTERADDIAMLMTLELGRALPDSRAETTYGLEFLRWFAEETVRIGGRFTPAPAGNGRILVAHQPVGPCLAITPWNFPLAMGTRKIGPALAAGNVIIVKPARETPLTMLALAEAFAEAGLPPGVLSVLPTTSSGEVSSTLITDDRIRKISFTGSTPVGRSLLGQAAERVQRTSMELGGNAPFLVFDDADIDAAVEGAFAAKMRNGGEACTAANRFLVQAGVVEEFTEKLVAKMSEVRMGPGYSDGVTLGPLVNADQRDKVADAVEQAVADGARVRLGGERPEGRGFFYPATVLDNVDPYAPVTREEIFGPVAVISTFDDESAGIEAANSTEYGLASYFYSRDLERCMRVAERLDSGMVGVNRGVISDAAAPFGGIKQSGIGREGGSEGIDEYLSVKYIALT
>NC_018581.1|WP_083889016.1|1032672_1033593_+|SGNH/GDSL-hydrolase-family-protein
MGTLTGLVAAGALLAGCAQSTQTPAQSTQTDAQSTQAPVQSTEMPAQSTEKPAQSTVYVNLGDSFSAGTGVSPLEEDSPIYCQRSSRNYAHIVAEEEDFDLTDVSCAGADTGDFRESQHQGVPPQLDALDEDTDVVTLMIGGNDEQTYGRAIRLCSELADVDRAGAPCTDRYGRSLIDPVAADIYPAVRQALRDVRNRAPNARILLAGYPWLLPPTVGCYPEMRLAEGDVPMIRELQTALNTYGRRAAEDEGVEFVDMSQVSEGHDACAGDERWIEPMTTSGPGAVHPNEQGQAAIAEQVRKALAG
>NC_018581.1|WP_014925556.1|1033677_1035027_+|glutamate-1-semialdehyde-2,1-aminomutase
MTPSAAATPAPGTAASAALFTRATQAIPGGVNSPVRAFSAVGGTPRFIASAAGCRLTDADGNAYVDLVSSWGPMILGHAHPAVVEAVREAATGGLSFGAPTEGEIELAEEIIGRVDPVERVRLVNSGTEATMSAIRLARGYTGRAKIIKFAGCYHGHVDALLAAAGSGVATLGLPTSPGVTGASAHDTLVLPYNDLTAVAEAFAEFGDDIAAVITEAAAGNMGAVAPVEGFNAGLRDLTRRHGALLIMDEVMTGFRVSPSGWYGLEGVAGDLYTFGKVMSGGLPAAAFGGRADVMERLAPTGPVYQAGTLSGNPVAVAAGLATLRHADVEVYRTLDANADRLATMLHEALSAAGVAHRVQKAGSLLSVFFTTDPETPIVDYAGVSATETWRFAPFFHALLERGVYAPPSAYEAWFVSAALDEDAFSQIADALPAAAQAAATAATPGDNA
>NC_018581.1|WP_010842019.1|1035026_1035653_+|histidine-phosphatase-family-protein
MHTIVHMMRHGEVDNPDGILYGRLPGFRLSADGQAQARKVADTLADHDVRAVFASPLQRAQETATPIAAAHGIPILTNDDLIEAENVFEGLKVSVGDGALSKPRHWPKLRDPFTPSWGEPYIQLAHRMLAAANKARDAARGHEAVCVSHQLPVYTLRRFLEGQRLWHDPRRRQCSLASLTSLIYDDDALVDIIYSEPAGSSDPLATGA

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Crispr_ID: NC_018581_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018581_4

2770325-2770403

Orphan

Consensus_repeat	Method
CCCTGAGGTGCGAGCGAAGCGAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018581_4

>merge|NC_018581|4|2770325-2770403|CRISPRCasFinder
CCCTGAGGTGCGAGCGAAGCGAGCCTCGAAGGGTCCCGACACCGACCCTCTGCCCCCTGAGGTGCGAGCGCAGCGAGCC

>NC_018581|4|4|2770325-2770403|CRISPRCasFinder
CCCTGAGGTGCGAGCGAAGCGAGCC	TCGAAGGGTCCCGACACCGACCCTCTGCC
CCCTGAGGTGCGAGCGCAGCGAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018581.1\|WP_014926786.1\|2765041_2766856_-\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014926778.1\|2757494_2758550_-\|MSMEG_0568-family-radical-SAM-protein	unknown	unknown	gnl\|CDD\|274940
NC_018581.1\|WP_014926794.1\|2778204_2778522_-\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014926789.1\|2768742_2770257_+\|DUF3375-domain-containing-protein	unknown	unknown	gnl\|CDD\|371764
NC_018581.1\|WP_049942595.1\|2777133_2777535_+\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_010842624.1\|2763948_2764635_+\|transposase	unknown	unknown	gnl\|CDD\|223505
NC_018581.1\|WP_014926791.1\|2771173_2774518_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227250
NC_018581.1\|WP_014926799.1\|2785964_2786453_-\|DUF3293-domain-containing-protein	unknown	unknown	gnl\|CDD\|378695
NC_018581.1\|WP_014926781.1\|2760138_2760609_-\|MSMEG_0570-family-nitrogen-starvation-response-protein	unknown	unknown	gnl\|CDD\|274939
NC_018581.1\|WP_014926788.1\|2767502_2768618_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NC_018581.1\|WP_014926787.1\|2766905_2767301_-\|PLDc-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379161
NC_018581.1\|WP_014926780.1\|2758870_2760142_-\|MSMEG_0569-family-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274942
NC_018581.1\|WP_014926796.1\|2781803_2784611_-\|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl\|CDD\|378929
NC_018581.1\|WP_010842625.1\|2761526_2762051_-\|MSMEG_0572-family-nitrogen-starvation-response-protein	unknown	unknown	gnl\|CDD\|188559
NC_018581.1\|WP_049942593.1\|2775926_2776808_+\|SIR2-family-protein	unknown	unknown	gnl\|CDD\|238697
NC_018581.1\|WP_044506674.1\|2777637_2777961_-\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014926792.1\|2774895_2775453_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370725
NC_018581.1\|WP_014926795.1\|2778552_2781807_-\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|224000
NC_018581.1\|WP_044506678.1\|2786449_2787397_-\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014926782.1\|2760601_2761513_-\|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|143587

Protein	Function_ID	Function_description	E-value
NC_018581.1\|WP_014926778.1\|2757494_2758550_-\|MSMEG_0568-family-radical-SAM-protein	gnl\|CDD\|274940	TIGR04043, hypothetical_protein_WH5701_02349, radical SAM protein, MSMEG_0568 family. Members of this protein family are radical SAM proteins related to MSMEG_0568 from Mycobacterium smegmatis. Members occur within 8-gene operons in species as diverse as M. smegmatis, Rhizobium leguminosarum, Synechococcus elongatus, and Sorangium cellulosum. The function of the operon is unknown, but similarity of MSMEG_0568 to some cofactor biosynthesis radical SAM proteins suggests a similar biosynthetic function. [Unknown function, Enzymes of unknown specificity].	0
NC_018581.1\|WP_014926789.1\|2768742_2770257_+\|DUF3375-domain-containing-protein	gnl\|CDD\|371764	pfam11855, DUF3375, Protein of unknown function (DUF3375). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.	1.52928e-102
NC_018581.1\|WP_010842624.1\|2763948_2764635_+\|transposase	gnl\|CDD\|223505	COG0428, COG0428, Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism].	1.78128e-08
NC_018581.1\|WP_014926791.1\|2771173_2774518_+\|AAA-family-ATPase	gnl\|CDD\|227250	COG4913, COG4913, Uncharacterized protein conserved in bacteria [Function unknown].	7.29042e-102
NC_018581.1\|WP_014926799.1\|2785964_2786453_-\|DUF3293-domain-containing-protein	gnl\|CDD\|378695	pfam11697, DUF3293, Protein of unknown function (DUF3293). This bacterial family of proteins has no known function.	7.91206e-14
NC_018581.1\|WP_014926781.1\|2760138_2760609_-\|MSMEG_0570-family-nitrogen-starvation-response-protein	gnl\|CDD\|274939	TIGR04042, conserved_hypothetical_protein, MSMEG_0570 family protein. This small protein, about 90 residues long, has no detectable homologs outside the set used to characterize this model. Member proteins serve as markers for an eight-gene region whose overall function is unknown. One member of the cluster is a radical SAM protein with some similarity to enzymes of cofactor biosynthesis, another a glycosyltransferase, several hydrolases or oxidoreductases, and several unknown.	2.2407e-36
NC_018581.1\|WP_014926788.1\|2767502_2768618_-\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.08949e-51
NC_018581.1\|WP_014926787.1\|2766905_2767301_-\|PLDc-N-terminal-domain-containing-protein	gnl\|CDD\|379161	pfam13396, PLDc_N, Phospholipase_D-nuclease N-terminal. This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, pfam00614. However, a large number of members are full-length within this family.	2.4095e-08
NC_018581.1\|WP_014926780.1\|2758870_2760142_-\|MSMEG_0569-family-flavin-dependent-oxidoreductase	gnl\|CDD\|274942	TIGR04046, predicted_flavoprotein_involved_in_K+_transport, flavin-dependent oxidoreductase, MSMEG_0569 family. Members of this protein family belong to a conserved seven-gene biosynthetic cluster found sparsely in Cyanobacteria, Proteobacteria, and Actinobacteria. Distant homologies to characterized proteins suggest that members are enzymes dependent on a flavinoid cofactor.	0
NC_018581.1\|WP_014926796.1\|2781803_2784611_-\|PD-(D/E)XK-nuclease-family-protein	gnl\|CDD\|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	2.85569e-26
NC_018581.1\|WP_010842625.1\|2761526_2762051_-\|MSMEG_0572-family-nitrogen-starvation-response-protein	gnl\|CDD\|188559	TIGR04044, MSMEG_0572_fam, MSMEG_0572 family protein. This model describes a family of proteins with remote similarity to the DsrE/DsrF-like family (see pfam02635). All members are found in a context of at least seven genes that includes a radical SAM protein, suggesting biosynthesis. The system is sparsely but broadly distributed in bacteria, including Actinobacteria, Proteobacteria, and Cyanobacteria.	6.82939e-92
NC_018581.1\|WP_049942593.1\|2775926_2776808_+\|SIR2-family-protein	gnl\|CDD\|238697	cd01406, SIR2-like, Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.	8.28116e-30
NC_018581.1\|WP_014926792.1\|2774895_2775453_+\|hypothetical-protein	gnl\|CDD\|370725	pfam09855, zinc_ribbon_13, Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082). This domain, found in various hypothetical prokaryotic proteins, as well as some Zn-ribbon nucleic-acid-binding proteins has no known function.	0.00372947
NC_018581.1\|WP_014926795.1\|2778552_2781807_-\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	4.33581e-111
NC_018581.1\|WP_014926782.1\|2760601_2761513_-\|carbon-nitrogen-hydrolase-family-protein	gnl\|CDD\|143587	cd07197, nitrilase, Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes. This superfamily (also known as the C-N hydrolase superfamily) contains hydrolases that break carbon-nitrogen bonds; it includes nitrilases, cyanide dihydratases, aliphatic amidases, N-terminal amidases, beta-ureidopropionases, biotinidases, pantotheinase, N-carbamyl-D-amino acid amidohydrolases, the glutaminase domain of glutamine-dependent NAD+ synthetase, apolipoprotein N-acyltransferases, and N-carbamoylputrescine amidohydrolases, among others. These enzymes depend on a Glu-Lys-Cys catalytic triad, and work through a thiol acylenzyme intermediate. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. These oligomers include dimers, tetramers, hexamers, octamers, tetradecamers, octadecamers, as well as variable length helical arrangements and homo-oligomeric spirals. These proteins have roles in vitamin and co-enzyme metabolism, in detoxifying small molecules, in the synthesis of signaling molecules, and in the post-translational modification of proteins. They are used industrially, as biocatalysts in the fine chemical and pharmaceutical industry, in cyanide remediation, and in the treatment of toxic effluent. This superfamily has been classified previously in the literature, based on global and structure-based sequence analysis, into thirteen different enzyme classes (referred to as 1-13). This hierarchy includes those thirteen classes and a few additional subfamilies. A putative distant relative, the plasmid-borne TraB family, has not been included in the hierarchy.	1.26115e-73

>NC_018581.1|WP_014926789.1|2768742_2770257_+|DUF3375-domain-containing-protein
MEFSAFPAPVEAPGASSAPESAQLTLADAWESNRSIQKSAVGRLFAATNSALYVTLMERHLDYGTKLSETELSVRLDRDLADLELTDQANGLELVKMWARQGWLHRVTDTTDPNAPNLCHLTSEARSVLDFMRRQRREDSIATGGSITGIAAELRRVAGQVSNDPDQIRSEIEAQMSDLDAELADLDAGRRPPVDLRVAEDAARTIGYQMEQIISDIGQYGTMLDRITTALLDDPGDSDLAYRDRQRQLFDDYEALLDSPQSASYQAFSQMIQDPERRARLKHDIETIVDNFPAMDAGLRSVMDNFFGLVTQQMAEVGRTRQRCARRIRRFVASGTLEQSRGLARQLNDALATANELLKTSLADRRIGYELPLATPTVNSIGRLAFEIREHVPPAPALPAAVDADLTSFASLSGQVDTTELTDTVNAAVAAGPVALADVIGGLEEPYLAHVIVLWSWASKQQAAGEKVPMTTVRFRSLIGDDHAIEVPDLTFTEPIPTAEVDAE
>NC_018581.1|WP_014926788.1|2767502_2768618_-|alpha/beta-hydrolase
MVMADRPEVQTASAPVTALTVVGLAQSMINGLARVPFRKPWSGPSGLLDNVGQSVTRQTIRAFMGYSMGLPIEEFRSMEKILDDLCRIVMPPFVELTDGVELTDDIVGGVPGLWCRAKASSDAYVDDEKDKEEIGATILYLHGGGYIGTSPMMYSAFAASLVRIAGHEVFIADYRMAPEFPFPAGVHDAADVYRGLLGRGVDPDHIIVAGDSGGGGLAASLVAYLHDHDLPRPGALALFSPEIDLDLDHPSITENAQYDILPWSIPVTPYLHGVQPNDARVSPVNAEPDPSWFPPTFVCWGGSEMFRDGIRDFAARLEASEVPTHAIEEPGMFHVFPILMPWAEASKRVFRALSELADGHVEGDPDAAQTH
>NC_018581.1|WP_014926787.1|2766905_2767301_-|PLDc-N-terminal-domain-containing-protein
MPYLGLIYLVILVVALIDIIKTDDAAVRGLPKFAWVVLVVMIPLAGALVWLAVGRPTADERPRRQHSGATSEFPEYDHPGRYIPRDPEADREFLRQVRERAEQQRRTAREQQRAADRTDRTDDEGLPPTTT
>NC_018581.1|WP_014926786.1|2765041_2766856_-|hypothetical-protein
MTSWPEIRGLSYSTMGRTARGTVYSSDGTASSVWFAPPTSWRMEVADGSPSYIESATDEYVFRGDGVAVHTAKHPNRLVAVTGVSPTVLFTAYRSWTPMELTGRPPRFSEPHQLIEAEVRGRRGWQVEFDDSYGGPTITMVLDAELGIALSWRQGEQWVQMESPVLDEDFDPALFTWDGPAVEFEEYLESREQLEHQQKMQELMNMPPTHIGWVPMQVTASPTDGDPLSGALDVTVTASSPQFGIRRWLTKLGEPEVGFSMELYSPRARTTIGPWTVELRSYNEISADDADRVLAELGLPDPPGAVGDIRDATTARQEAAEEAEIVSALGIGRDLDDYLHDSYGVSLLVRTDFSDDRRWREIALAAMAPVDSGMDDESTFEAGLTCIDHRDNDGLTVEALVERIGDDPPYYAFVADSVTMFHPEMAILVVDCGRTDFGHEPGRTFRVIPEQMQSVENNLSISNMDFRDFADSVDDDGVFRGFAPSPPHVAILQRDELLALSATNRSTPALARFAEELPQVDHPSMVVYETTRTKVHDSVAALDDPPANEIRVGVEDYLAATAREGMCRHGFVQIRGGHWSLVIDPDTGTLEAAMLRQYQPSTPS
>NC_018581.1|WP_010842624.1|2763948_2764635_+|transposase
MLTAVLYGLATAVPIAVGAAIGLRWNLPNPILATLMAFGAGTMIAAVSTELFEPAFTQAGTGVAAMALFSGTAVYVVADRLVETKLGSSAIGPALMIGVFLDGVPENTALGVSLTAGGSLVLVVAIAVGNVPEAVSGASLMRREHDASIRSALAMWLFTAVVLVAVTVGGYAVADAISPTAISVVQAFAGGATLGVLANSLMPEAYREGGWWVGLATAGGFLLAFVLG
>NC_018581.1|WP_010842625.1|2761526_2762051_-|MSMEG_0572-family-nitrogen-starvation-response-protein
MPSFDETITENIAASLAEIPHPSLPKGSSIYGGTKIFPDYQAENGESYFTLVHGIAHESSVSFVAVLQATRALRKGFESAMYFYGPGAINCLATRGFPTTGDSGFPGEQNINNSLETFISEGGTVFCCRFGLALHGGREEDLIEGVIPAHPLDVQDALIHYARKGAIINSTYMV
>NC_018581.1|WP_014926782.1|2760601_2761513_-|carbon-nitrogen-hydrolase-family-protein
MTTIGTVAANFTRDLEQNYATIEQYVGEARTRGVDFLVFPEAAIGGYLSSLGNHGDTRKNSARSLPPAISLDGPEIARVQSIVGDLVVAIGFCELGEDGETRYNAAAVLDGNHIYGSYRKVHQPLGENMSYSSGDGYGVFDTPVGRIGLQICYDKAFPEAARIMALKGAEIIASLSAWPAARTATAENLQDDRWTYRFNLFDTARALENQVFWVASNQSGTFGSLRYVGNAKIVDPGGNILDTTLLGSGLAVAEVDIAESFTAMRAGMFHLRDRRPEVYGMLVETDSDSDAGADFAWRDLAHA
>NC_018581.1|WP_014926781.1|2760138_2760609_-|MSMEG_0570-family-nitrogen-starvation-response-protein
MPEMTVQVRWPDGLFRQYYSPSLVLHDHLAPGTYRVDDFRSRATTALDEASARVRAKYGFACTSAAASAEEIAVDAARHPDSAEVEVVSMYPPLPGAEVASTRGVASLRPGSTSGGDAGVASLRPGSTSGGDASVASLRPGSTSGIPGPANTEEQL
>NC_018581.1|WP_014926780.1|2758870_2760142_-|MSMEG_0569-family-flavin-dependent-oxidoreductase
MNAHVPVVVIGGGQAGLSVSWYLGQAGVEHLVVEADTAVHAWADKRWDNFTLVTPNWHCKLPGYTYDGPEPDGFMTRDEVVEWLHGWLQTFEPPLVEHTKVTRLQRLSGDRFELTLDGPDGIHSITCDQAVIATGGYPLPVVPPFAPSLDLAVHQVHSEEYFNPEQLPDGAVLVVGSGQSGTQIAEDLHLAGRQVHLAIGNAPRVARFYRGRDCMTWLSDMGLYDTPTQEYPGGRAAQEKTNHYVTGRDGGRDIDLRRFAVEGMKLYGVLTDGKDSTLRFAPTLTAALDRADAVYNSICGDIDRHIDKHGIDAPKGSRYEPVWVPDVDPSELDLAAEGVTSIIWAIGYRPDYRWIEASAFDGGGRPMQTRGITEVPGLSFVGLPWMHTWGSGRFLGIDRDARYVAEHVVEAVRSGQPYLAAAQ
>NC_018581.1|WP_014926778.1|2757494_2758550_-|MSMEG_0568-family-radical-SAM-protein
MTVSTRVDLALLGIRGDPPLQRSGGAGPSDDGHLMVDGLHAAIPRNPQSPFVFDGDRVLYDGVDIGVEVSAIGRPRFYDLQTAEGVSYEKIARLHGRNVLATTVLQTCIRYAEDQRCRFCSIEESLKSGSTIAVKKPEQLAEVARAAVDLDGVTQMVMTTGTSGGRDRGARHLARCVRAIKEAVPELPIQVQCEPPADLAVLTELREAGADAIGIHVESLDDDVRRRWMPGKSTVPMAEYRAAWAEAVRVFGRNQVSTYLLVGLGEDTDEMIAGAKELADMGVYPFIVPFRRHVGTLAVDVDNAPAPDPAIVEKISREVAGHLCFIGMSGSEQRAGCAACGACSVLPTVGG
>NC_018581.1|WP_014926791.1|2771173_2774518_+|AAA-family-ATPase
MSGQVDQYHLSRLQLINWGVFDGYHSIPFSPNGSLITGSSGSGKSSLLDAISLAFLPDHRRNFNASGDATAAGSSSGKRTVGKYVRGAWGERRDGTNAHREIMYLRGTGPAWAAISVTYTSSSGEAITGLVLKWLAAGKMTDAHSSYFIYDGDADIVEACNEWAANNYNSAKFRDRGWRGGPGEGKYLSTLYSLIGIRGSDAAQQLLGKAKSLKSVGGLAQFVREFMLDAPTSIVGIADALDQIDPLVEARELLDVARRKRTILGNIEEVHERYAGEAATFSVLDTIDNTTIRSYVNNLRIRNAEPEVADLDDQITRLDGDLAALTTQHDQLRQDHSLLLSRIATSTGDLAPLREQLGGAQKLSTEVTARRNAYEDKVSALGFTPPTRAEGFWLLREELQEEATKIDGQLDAGRAHYAEALASEVAARTRRDAAMEELGRVENAGSALPRTEHEMRRVIAHGLQIDESELKYVAELVELDPDEERWRLAVEKVLRNVGLRLLVPDKHFRAALRFVNSHDMRGRIQLHQADSRPMPVLEPGTLASKLRPVDASHPGAAEAMTVLSKLGSHMCVDSPGEFSQYAKAVTDQGLRKDSAKLAVKDDRQQLRRSQYIFVGDVASKIAALRDELDYEERAFEDARQDCAELDRERSAKEKRRDAYRRVCEQFTQWNEIDVDSVDDRVDQLTDQYDLLIEENPDVEALQRKAEDLWEQVRNAISQAALVKDKIARQDSRRTQLLDLIDRLKPEDVPAQAEKTLDGFREDLSATLDVLNPEPYRQEIVKAASRERDRMRSDARRSRDELARILDTYDEEFPDAIPNDSDDFDERLHDYVAVCRRIDERELPAAYERMRRLITEQAPGAILGLHMAADAEERRIVEQIERVNTGLGAVAFNRGTRLRLRPGRKKLAAVEELTEKARQISNRATAVSFGDEQAILEQYSDILLLRERLAGNTPEDRQWTRDALDVRNRFDFYCEEHDAESGETIRTYSNAGDNSGGEQEKLMAFCLAGALSFNLASPHGNDNRPIFAQLMLDEAFSKSDPQFAQQALSAFRKFGFQLIIVATVQNTSTIQPYVDNVVMVSKTEAGPELRPIATATSTGIKAFSELRRSGSQLPV
>NC_018581.1|WP_014926792.1|2774895_2775453_+|hypothetical-protein
MSDYWVEFMSLDADENQASDLVDAQITWLLSQEIIAPSAKPDAFYGTFREGPRFADAMDPEWIETGAVAGGRYILFGVRIKKGWQMSHNIGGFEGPPCPRCGHQQFDGGAAGALILDWYESRAEPTVNCTNCGHIDLIGNWPHELFGYCNYASLSFINCPTLAGEFSDELLARLGNRPRAIDVRL
>NC_018581.1|WP_049942593.1|2775926_2776808_+|SIR2-family-protein
MPVFGIAGGGKGGLKGLVIRDLVTLLRSVAADRSLDVALVTPDRSVYSALQHFRRTATAVHWELSPGQLRVAKDLGTRARDGDLALFLGAGVSVSAGLPGWKALLEELGSRAGVDANTLMNLEDSPLDQAELISLRLGDNLGSEIARIVRRAKKVSLAHPLVAGLRCREVVTTNYDELYEDAVEATGELRPTVIPWEAVQPRRPRVLKMHGEVGRPESVVLTRRSFVRYDANSRPAGSLLQALMMTRHVLVVGTSMSDDNVIRLAIEVDDFLESDDSFGTFIDVSESPARAEL
>NC_018581.1|WP_049942595.1|2777133_2777535_+|hypothetical-protein
MGDEPRTSTWYSCGRSSEPSTDTKRLTSYEDARGELAKLLSPFRIAESAPKPVDPWFALGTSSWWEIRDLPSSSKVQDVIQRNARAGLSVNVYNLVRRDSVFAQEAVERLVKLIAEDVESASLLEDLRRQLSS
>NC_018581.1|WP_044506674.1|2777637_2777961_-|hypothetical-protein
MSMNYDQVLIEWAHTYNGYERLAAGPGKLYELLAPLRQEFDQHGMVPDWAGIDLLRGWAFYLVRAHRHSGGYEPFTVEYPEVYAIADAIDKHAAVTDADRPPARPGN
>NC_018581.1|WP_014926794.1|2778204_2778522_-|hypothetical-protein
MTETEHPLIDDPQAPWNWRTVDEATAQSELGCELLYEYDGSWATYDEVVASVTAEADTIPADKSRWRDGDFDADEYIDEACGWGVIGTIEVRTRIATEYTAASSD
>NC_018581.1|WP_014926795.1|2778552_2781807_-|UvrD-helicase-domain-containing-protein
MTALALADQAARDRIATATSTTLFVEAGAGSGKTHSLVSRICSLVLDEGVELHTIAAITFTEKAAAELRERVRVELAKHDTDRANTALDQVDVAAIETLHAFAARIVRQHPLEAGVPPRVEIVDAMGSELSFERRWRRMQNRLYTDEASPVLVDALGILMARGVSVDQVKKLADALDRTWDWLELGDEPAGIAPADVDRILRETDLIVDRLTDCLDREDKLAMKLEELREWRILVAAEQDAFGWIPMVALCPKVGNVGRGAAWRGGTTQRKAIQQAVKDLRDIVFPDVVDSYIAAAVEVVVWHLTEVVLNEATKRQRSGQLEFHDLLVLANRVLDNTHVAADAHARYQRVLLDEFQDTDPLQIALAEKIVAGPDHPGRLFTVGDPKQSIYRFRRADISVFMGARKQTPDTDVVQLTTNFRSTRPVIDWVNRVFGALITPSDNVQAEYIPLDPAPGRPEWDPEWGPTPLVFISDEQVSDEASLSDADVTRARESRDVARIIATAVERGWCKESFTGSGYDHQAVQWKDICILIPSRTVLPYLEKSLDEAGIEFRSEASSLVYSTQEVHDLLLACRALANTADEAALVGSLRTPMFGCGDDDLLRWRAAGGYWSIFAEAPDDLQDSPIARAFAYLRSVTDELGSLNPATLLSKLATDRRVFEISMDSPRHRDVWRRLRFVIDQARAWYAEDRGSMRDYLDWAATQADENARVAETVLPEIGVNAVRIMTIHAAKGLQFPMVVLAGMSGGFRTQPEPVLVDNSGALQACISTSATTKGYPAARDAEKVHAEAEKIRLLYVACTRAESHLAVSGYAAKRGASWGSILAPALDGLPNDVPSLVEPVRRDDEAVRSEVRQSWDEWTLETARVRDASSIRPSYTVTDAVHSDDLDARAILAGYRDAGLLPTANGSEVVPAGRASHDSGKSYGTALHAILERIPLSADHALIDEAARGTAYTQGIEDVEHFVDTIRSTLASEPVRRAADREHWREMQLAGLGPDGTTVIEGIADLIYREDDGSLVVVDYKTDVGVSATTLEQYWSQLSIYAHLVTTVAGERVSALKLVFSRAGESAVLSRTAERRAAPGNYP
>NC_018581.1|WP_014926796.1|2781803_2784611_-|PD-(D/E)XK-nuclease-family-protein
MTRPVDSLVAAVCAAKAKSPLALVTIVVPSPGAARDVLHHLARRGGVANTRVLTVPQLVAALATPALAPRLPLRYPLLEAAIERVLMDAPGAFHEVAQEPATSRALSAAAWELTTLSHPEMAYETPLVTDLLRVYRIAVERLTSRYFLQHEAYAAAGENLPEVGKIIAYRLQPTTAADAALIERLENVGVVVASDPVAAPTQVIHTSDADDEVRAVVRLVRKHLADGVPGHRMGIFYPTEDPYLPLLQEHLTAGNVTFHAPECHTLVDRPIGRSVLGLLSLDTTKMPRRELLSILADGALTRPRVDNKPLSQPQLERLTRHIEPIVGGDDWHKLMHVAAEKKHHPSSIALYDYVQRLQKRLASTGYAPDWGTVAAELGSLLDVTFRTQTSDVGHADLTAVRQAVADLDLLDGLAAVPSPARVHAAVAVRLESFRGTLGNSRIGVTVAPLSAGVGRELDISIVVGVAEGMVPGRRADNPLLPPDLVGITAREHVDQQLWAYTNALNAGTIARIATFPRGSLRGGAEKVPSRWLVPALTDLAGRKVNVVEWQRQTQDATSIVAVESFDVAAQHADERIGASAASPTEWRLRELAGVPAYRRRGALDDPVINLGMQMRSDRLNGRFTRFNGNLAEVCELISTFDHPVSPTGLETWVASPYQFFLEHILRLTTLDDPDEAAQIDALTRGNLVHAILERYVIDSIEGTELDFARLSLVAQEILDNAEADNPGWLQQLWAKDRGIIVRDLADWFHHDHADKASGWKPTHAEEQFGTEATVVLLIGNNMIRFRGKIDRIDTHLDGRVRITDYKTGKVDKKYNEISVDTPTGGGKQFQLPVYGLFARTFGDNVEARYWFVTRKGEFTSVGYPVTDSVVATLADDLALVHRCISDGQFPPKVADTFWDLPVIDLLGRSGLNRAWANLENVRELADYVQKYGGRV
>NC_018581.1|WP_014926799.1|2785964_2786453_-|DUF3293-domain-containing-protein
MNSHSDFSWPTVSKLAEYAADDQLWQNYLNTKVSIESAMATGTVWPADRSDPQLQLPDFHVVTAVLPDTDPLSADNAARIKVLDDELDSAGLAYAQAVGASFDGSYSEDSRAVFGLTDEEARSLGARFGQVAVFGLRGARWSLIACGSNRRNDRGWRWEPRS
>NC_018581.1|WP_044506678.1|2786449_2787397_-|hypothetical-protein
MSEIVYEIVRRKSDIENGQEHEHVRLSRSADRLTRCVDGESDAQIPEGTTPLAAIQQDERLGVVHEAELSSISVAPDLAPRMPLFLRVRVTGDQLPDRDDWDVTINDVPHAPFRTTSDTLRLLPVDSDLDIEFSTTWASISFCETGSMTSGLDTVTLGLISDSVAVSSTRLDPLVGAPEMPVQLWDLTDDSTPKIVSDWITANGLIDYLTTPSTMLVRLFAESAGADKRTEPTVRWGDFLAGEHADDGEIGCGPSARWELRLDLPPEIVQATLDRLSAEEREYAVIIQGVDDPGPIDDNTRTAPTPMHGTRRSDS

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Crispr_ID: NC_018581_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018581_5

4557415-4557509

Orphan

Consensus_repeat	Method
TGAGGTGCGAGGAGCGATAGCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018581_5

>merge|NC_018581|5|4557415-4557509|CRISPRCasFinder
TGAGGTGCGAGGAGCGATAGCGACACCCACCCTGCTCCCTAATCCGAAAGAACCGCATAACCCCTGGTCCCTGAGGCGCGAGGAGCGATAGCGAC

>NC_018581|5|5|4557415-4557509|CRISPRCasFinder
TGAGGTGCGAGGAGCGATAGCGAC	ACCCACCCTGCTCCCTAATCCGAAAGAACCGCATAACCCCTGGTCCC
TGAGGCGCGAGGAGCGATAGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018581.1\|WP_014928026.1\|4549741_4550155_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238780
NC_018581.1\|WP_044507231.1\|4565413_4567042_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|235730
NC_018581.1\|WP_010840724.1\|4548527_4549745_-\|O-succinylhomoserine-sulfhydrylase	unknown	unknown	gnl\|CDD\|236103
NC_018581.1\|WP_014928025.1\|4547422_4548499_+\|isochorismate-synthase	unknown	unknown	gnl\|CDD\|224091
NC_018581.1\|WP_014928040.1\|4567015_4567501_-\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014928032.1\|4556535_4557366_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NC_018581.1\|WP_014928034.1\|4559084_4560122_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_018581.1\|WP_044507228.1\|4554353_4555397_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182464
NC_018581.1\|WP_014928036.1\|4561849_4562764_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224332
NC_018581.1\|WP_014928042.1\|4568518_4569802_-\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|225779
NC_018581.1\|WP_014928033.1\|4557670_4559008_-\|ClC-family-H(+)/Cl(-)-exchange-transporter	unknown	unknown	gnl\|CDD\|238504
NC_018581.1\|WP_014928041.1\|4567527_4568409_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NC_018581.1\|WP_014928027.1\|4550792_4551818_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NC_018581.1\|WP_175404244.1\|4564625_4565417_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NC_018581.1\|WP_014928031.1\|4555393_4556539_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|376439
NC_018581.1\|WP_014928037.1\|4562877_4564593_+\|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl\|CDD\|223107
NC_018581.1\|WP_014928028.1\|4551995_4553393_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|215457
NC_018581.1\|WP_010840726.1\|4550151_4550622_-\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014928035.1\|4560267_4561833_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_018581.1\|WP_014928029.1\|4553574_4554081_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_018581.1\|WP_014928026.1\|4549741_4550155_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238780	cd01522, RHOD_1, Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins.	3.42739e-43
NC_018581.1\|WP_044507231.1\|4565413_4567042_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|235730	PRK06187, PRK06187, long-chain-fatty-acid--CoA ligase; Validated.	0
NC_018581.1\|WP_010840724.1\|4548527_4549745_-\|O-succinylhomoserine-sulfhydrylase	gnl\|CDD\|236103	PRK07810, PRK07810, O-succinylhomoserine sulfhydrylase; Provisional.	0
NC_018581.1\|WP_014928025.1\|4547422_4548499_+\|isochorismate-synthase	gnl\|CDD\|224091	COG1169, MenF, Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.64601e-111
NC_018581.1\|WP_014928042.1\|4568518_4569802_-\|fatty-acid-desaturase	gnl\|CDD\|225779	COG3239, DesA, Fatty acid desaturase [Lipid metabolism].	1.4132e-49
NC_018581.1\|WP_014928032.1\|4556535_4557366_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	9.23261e-125
NC_018581.1\|WP_014928034.1\|4559084_4560122_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	5.36308e-20
NC_018581.1\|WP_044507228.1\|4554353_4555397_+\|iron-ABC-transporter-permease	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	4.67914e-75
NC_018581.1\|WP_014928036.1\|4561849_4562764_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.14522e-18
NC_018581.1\|WP_014928033.1\|4557670_4559008_-\|ClC-family-H(+)/Cl(-)-exchange-transporter	gnl\|CDD\|238504	cd01031, EriC, ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked proton utilization. As shown for Escherichia coli EriC, these channels can counterbalance the electric current produced by the outwardly directed virtual proton pump linked to amino acid decarboxylation. The EriC proteins belong to the ClC superfamily of chloride ion channels, which share a unique double-barreled architecture and voltage-dependent gating mechanism. The voltage-dependent gating is conferred by the permeating anion itself, acting as the gating charge. In Escherichia coli EriC, a glutamate residue that protrudes into the pore is thought to participate in gating by binding to a Cl- ion site within the selectivity filter.	7.99811e-105
NC_018581.1\|WP_014928041.1\|4567527_4568409_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	1.75277e-21
NC_018581.1\|WP_014928027.1\|4550792_4551818_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	1.85572e-35
NC_018581.1\|WP_175404244.1\|4564625_4565417_+\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	1.2763e-74
NC_018581.1\|WP_014928031.1\|4555393_4556539_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	7.72675e-68
NC_018581.1\|WP_014928037.1\|4562877_4564593_+\|thiamine-pyrophosphate-binding-protein	gnl\|CDD\|223107	COG0028, IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism].	6.72183e-145
NC_018581.1\|WP_014928028.1\|4551995_4553393_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|215457	PLN02852, PLN02852, ferredoxin-NADP+ reductase.	6.56367e-137
NC_018581.1\|WP_014928035.1\|4560267_4561833_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.15028e-59

>NC_018581.1|WP_014928032.1|4556535_4557366_+|ABC-transporter-ATP-binding-protein
MTASSLETSATTARLRGVGLTVGYDERIVIDGLDIDIPDGQVTTIIGSNGCGKSTLLRCLARLLPPRAGTVYLDGDDISSVRPKQVARTLAILPQNPIAPEGLTVADLVGRGRHPHQRWFAQASAADEAAVAQAMEMTDTLDLADRTLDALSGGQRQRVWIALTLAQDTDLILLDEPTTYLDLAHSIDVLDLVRKLRDEHGKTVVMVLHDLNLAARYSDSLFVMRNGAIVTTGSPSEVIDAETLDAAFGLRAHVMTDPVTGGPLIVPLDSRTHAKS
>NC_018581.1|WP_014928031.1|4555393_4556539_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MNPPTSIKTETDTAEKSGIRAKTRIAPHPGGYRIAIEPMSMVVRPRMLAVALVATAITIILFLTSVGVSDFPLTPIDVARILLGGGTRVENVVVFDVALPRALVALLVGFGLGLAGSLTQLIAQNPLATPDMLGITAGASVAAVTAIAFSTTSWGAWLGDLGVPAAAMIGGLATAVAMYVLAWPGRKANSGINPFRLVLIGVGMTWLLQALTQFLLSRADIRDVGRAQVWIVGSVANVGWSNVWPVVAGVCASIVVVIVLARQIGMLSLGPDLARGLGVRTGAVSTTLLLTAVLVAALSVSAAGPIAFVALLAPQIALRLAGTAVPTPLVSGVIGSALVLGGDLLCRTVLPGGLPVGIVTAAIGGPFLIYLMVVMSRKASV
>NC_018581.1|WP_044507228.1|4554353_4555397_+|iron-ABC-transporter-permease
MRRSLRVLGIPLLLATLAALVVASVLFGTRPVPLDEIWPSFTAGAQEIWNALINLRMPQVPKDTDVDGIVWDLRVPRTLLGLTAGLAIGAAGAITQGHTRNPIADPGMLGVNAGAACAVVGGIYLLGITSPIAFMFFGLIGAIIAATVVFGLSSLSGSSPLTLVLAGTGLTAMLTAITSAIVLVDTNSLDQWRFWSVGSTAGRGIDVFWASLPFIGVGLVLALASGFFLNVLSLGDDMTKALGSRVVLIRALGVLTITLLIGAATAACGPIVFLGLVVPHIARAFVGADYRWIIPYSALLGGILLVGCDILGRIVARPGEVQVGVMLALVGAPFLIVMVRRQRLGTV
>NC_018581.1|WP_014928029.1|4553574_4554081_-|hypothetical-protein
MKSLKRALTGVLVAAGIAGGSLVGAAPAHAAVPNLQMTGGVYCQFGAPGTPWNQAWSMTRFMRVTARDGDFRNVTLQEINGATKFKSQLKKNESLTIKTVWFGCFPSSIAGYAISDYAENLTDNAGFWWNVRRIDNPLDRFGTGSSASAAALTGGGTDVEGVPAIPGR
>NC_018581.1|WP_014928028.1|4551995_4553393_+|FAD-dependent-oxidoreductase
MSDNSRPLRVAIVGAGPAGIYAADALMKSDTAKDRGVSIDLYERMPAPFGLIRYGVAPDHPRIKGIITALHKVLDKPQVRLLGNVDYGTDITIDEMRAHYDAVIFSTGATDDRALDIPGIDLDGSYGAAQFVAWYDGHPDFPRTWPLEAEKVAVIGVGNVALDVARVLAKTGDELLPTEIPANVYEGLKANKAIEVHVFGRRGPAQAKFTPLELKELDHSPNIEVIVNPEDIDYDEGSAVARRGSKITDQVATIIENYAIREPKQGAIHKLFLHFFESPTEILGEDGKVVGLRTERTQLDGTGNVKPTGKTTDWEVGAVYRAVGYLSDNLPQIPFDSQAGVIPNEAGRVFDEGQQLTGIYTTGWVKRGPVGLIGHTKGDANETVDCILKDMEAGALLEPAHPGEDAIVELLESKNIPFTTWDGWYRLDEHERALGAAEGRERVKVVEREDMLAASEPNKVSRPSA
>NC_018581.1|WP_014928027.1|4550792_4551818_+|ABC-transporter-substrate-binding-protein
MRSTTHRTLTLLVGLLTAALLATSCSPPDETVDSGTAQVPAPEAGAIPVTVQQAYAPATVAQAPKRIAAMGVGDGDTLLALGVTPTTIAPFADPDQASAPWNAELLADSTPVVLPNVSGAFGDEIPKALATEPDLITAVGADPTRDQFDLLSKTAPTILRPAQFQPWQVPWDAQTRQIGTAVGLPELADRKVAETEQFLAGVREQNPQLAGKTAVVVTASPTGGVSIYGPGDGRGQTVAGYGLTFPPALQPSVTSGFYGELPAESLNLLDSADVVVAVDWEGSNDRLKANAAFNRLTVAQSGRVVYLPQEVGSAMSVPTVLTIPWVADQAVEPIAAAAGKA
>NC_018581.1|WP_010840726.1|4550151_4550622_-|hypothetical-protein
MAEAAGEGDQRPPSWKNAWPFFVAAGVVGLVVLGVVLSNVIRPAEDRAGDSAQVQYAINDVYTARNGPNYAEYRANTCAADVEAADFVSEEQFLADNRESLVANGHIEIPEITELVVDGDRATAKVHWHYDKTPDDVNVVDTIVVRENGEWKVCSS
>NC_018581.1|WP_014928026.1|4549741_4550155_-|rhodanese-like-domain-containing-protein
MTYAGDLTPREAWEKLENNPDAVLVDCRTQAEWSFVGVPDLEVLGKRTIFAEWTTFPEGRRNDDFITQLRDSGVSDDHEVIFLCRSGHRSIGAAEAATADGIAKAYNVVDGFEGALDENDHRGTSGWRAENLPWRQS
>NC_018581.1|WP_010840724.1|4548527_4549745_-|O-succinylhomoserine-sulfhydrylase
MTSDLPVGRELPEGLSADTIAVRGGLARSGFHETAEAMYLTSGYVYDSAEAAERAFTGEDERFVYSRYGNPTVEMFQERLRRLEGAEACFATASGMAAVFVALGALLKAGDRLVAARSLFGSCFVVCNEILPRWGIETEFVDGEDLEQWERALSKPTDAVFFETPSNPMQSLVDVVKVSELAHAAGAQVVLDNVFATPLLQRGLELGADVIVYSGTKHIDGQGRVMGGAVLGTKEYVDGPVQQLMRHTGPALSPFNAWTLVKGLETLRLRVDASVSSALRIAEFLEADPRVRWVKYPFLQSHPQYELARAQMSGGGTVVTFELNDHDGIDGKKRAFEVLNGLRIVDISNNLGDSKSLITHPATTTHRAMGPDGRAAIGLSDSVVRLSVGLEGVDDLLGDLDQALG
>NC_018581.1|WP_014928025.1|4547422_4548499_+|isochorismate-synthase
MFVLSRPHGTVRGRGAVRGFTDVDAASAALRSGTIDGLTGAIPFDLADPAALVVPEVLHFDDAPLTGGPPLSRTPVSTTLHPTADEHRERVAHAVKRIVAGDVGKVVLARSVDIVLDAEVAPHELLDALAGGNAGHNAFGVDLGAATGSGAWLLGASPEVLLRKSGSVVTCHPYAGSAPRSPDPVVDRAVADGLFSSAKDLAEHAFVVDHLRDRLAHLCDDVDAPSTPQLQSTGEVWHLATPIRATLRDPSTTALDLALLLGPTPAVCGTPSDVAAQIIREVEGERGFYAGAVGWCDAAGDGEWMVTIRCLQLEADRRSLRTWAGGGIVEHSDPQGELEETAFKLRTVLNALGIDGLD
>NC_018581.1|WP_014928033.1|4557670_4559008_-|ClC-family-H(+)/Cl(-)-exchange-transporter
MTSPHRADRGLVRLSVLAVVAGLATGLLGGAFRWCLGHLDRWRVEMLDWSAGFGVPGWLVPIAVTAAGAAVGALAVRLVPTAAGSGIQHVEAVERGEAVPAPLRLIPAKFVGALAAIGSGLVLGREGPTVHMGAVVGSETGRRGGLDDVDVRVMQTSLSGAGLAVAFTAPIGGALFALEEVGRSFRLRLVLPTVFAVVAAVAVGRVILGDRPEFDVPSLDVPSVTTLPVFVVFGLVSGLIGIAYSRTVLGTLGWVGRFSRVPPIGRAALIGAAIGALLAIDARTAGGGDGLTQAVVDGGVVLPALVALFLVRFIAGPLSYAAGTPGGLFAPLLALGALWGAAFAEVADIVVQQSDPGGSGFRGAMILAGMAALFGAVVRAPLTGMVVVMEMTATTTVALPMLAATAAAVLVAHLSGSPPVYDSLRERMLSNSVRREDEPGPDSAP
>NC_018581.1|WP_014928034.1|4559084_4560122_-|Lrp/AsnC-family-transcriptional-regulator
MDDIDGTILRALQVSPRATFRQLGEVAGVSEQTAARRYQALRRAGVMKVVGIIKPSVRGQSEWVARVRCRPDRMEPLASSLARRRDVAFAYVASGGAEIICLIRAPLGASGEDAIAKTFPARASVTDVSIDLILHAFDPGHPASRWTGFGGHLDGRDRDLLASAAAGAGDDTPEDAEQDDSVSDAPAGGGRLTADDATLIEALVQDGRRPHRELARICGWTVGRVRRRLRALERAGALFYDVEILPDRLGFDLSATLWLTVTPSALDQVGTELAAHDEVAFAAAISGERNLMVSVICRDTAHFYDYLRTRVAAIDGLTGYSVSIRMRRLKQNASLVVQGRLIQPV
>NC_018581.1|WP_014928035.1|4560267_4561833_+|MFS-transporter
MTATTSPVITDVSAPPERRTATIVMACLGVFVAYLPITSVAVTLPAIGTAFGATTAQLSWVQDAFVLPMAAFILTAGVFGDVHGRRKVYLVGLCLTALGALVALSAQSISMVWIGQALAGTGAAALLPTTLALISHAVPDVRERGKFIGIWASALMLSLTVGPLVAGPVAESAGWRWIYLLPIPVALIAFAVAVATLPESRAPRARRLDWPGQISAAVSVTALVFGVIEAGVYGFGDTRVVLALLIAVVAAVVFVITEKRSASPMLDLDLFRSRAFTATTLVAMITFLALIGFIFVLSMYFGLVQQLGTIEAGWRLALMNGASMLVGALAGRMMHRIHARFLIGGSLLMVAVAQFALLTIDADTSFAAISWRLVVLGLGMGLVMAPMTATAVSAVPYHLSGMAAAGNNAFRQVGGALGPAVLGALLTAGAVNSLPQKLVDAGVDEPVRDRVVGAVDTDGLAAASGLNLGADTPAVMGAVGDAFLDGMHLCLTFSGVLTAGAAILALVMLRPGRAVEEQPVG
>NC_018581.1|WP_014928036.1|4561849_4562764_-|helix-turn-helix-domain-containing-protein
MARSSPQTERIVMLMQLLTDQPTTARSLADIARHLGVSKPTCYPMVIALTEAGWLLRDPVSKGYRLGPAVVPIGDAASRAMAPVEVARPLMRDLADDSDMAAIAFVPTGADLAIGEIVQPVTGRRGTLGLRLGDTLEIAPPLGAGLAAWYSPDRLDEWLLLGADHVGVGHAELRELYRPMLEVIRARGYAVECADQREQSLSATVAGLRGMGVAGQRAVTALREAQRRLPTDVVVGEIDADTEYRPISVNAVAFAPGGVPAVILAIVDARTSLSGREVIGLGEKVRAAADAVTEGLGGTSPVQP
>NC_018581.1|WP_014928037.1|4562877_4564593_+|thiamine-pyrophosphate-binding-protein
MATVNGGQLLARALAQAGTTEVFTLHGGHLDAFLIACAGEGIRLTDTRHEASAGHAADAYARVTGGFGVCVVTSGPGFTNVYTALANAYLDRSPTLFVVGAPPLRETETNPLQGGFDQIAAADPVTKWAYRITDAARVPEIVALAIRKATSGVPGPVLLELPIDVMFGEADDDQVRFPTNYRVPTRSGADPDAVTLALDLLHTASNPAIVIGGGVTFSRAEEALVTFAETVGVPVFYPGKADGAIPADHPLAGGGLLSMGTIPALGAPTPDVVLMAGTRAGMFTGGRASMFPGAKIIQIDIDAAEIGRIYDVEVPIVADCRAALEQLAAEAAGRTWPDWSEWAATVKAAKGAHAAGFPDAATDTGKMHPYFAAKAIVEACPPDTIFVLDGAEAPSWAEFFVAVGLPGSVLRLGYLGCLGVGPGFAIGAARARPGAPVVLITGDGAAGFHPQEFDTMARHHLPVTTVVFNNAVWGMSIHGQEAVFGPRGVVVSELADSDYEKIAEAFGGIGMRVKHIDDLAPAVDKALGAGVPACINAEIEPGIVHPITTMMLGDVTSTDEIVVPYYENLPR
>NC_018581.1|WP_175404244.1|4564625_4565417_+|SDR-family-oxidoreductase
MADQRVAGKIAVVIGGGSGIGEAAARTLAAHGATVAVADVNREAAESVAREIGGGARAHWVDVTDEESIAALLAGVSDDLGGVDTVVNCAGLNVPGFIVDLDAQQWHTTIELCLTGSFLVTKHAGRTLNDGGSLIGIASLNARQPAAGFAGYCAAKAGMVMLAEVAALELAPRGIRVNSISPGLVDTPLVQTLTSIPVIQDDFTANTPLGRNGRPDEIADAVLYLASDDSRWVTGETININGGAHLRRYPDVMRHLAEISAAQ
>NC_018581.1|WP_044507231.1|4565413_4567042_+|long-chain-fatty-acid--CoA-ligase
MTAPTQRDDAETRTATRAGGYRLAEQSRLRARLQGNAPALSGAGVHLTYRQLDDRTSRLANVLRDRGIRAGDRIAVLGKSSTEIIETVLAAAKIGAVTVPVNWRLSVRELGEVVADARARLIVCHRDFLDSVAEIRSNANTLIEPIVYGDPRQPRSYEQLVATASSSDPGHVGDADDVVLQLYTSGTTGRPKGVLTSNTNLGACTQAGGPWGFDESSVSLCAMPLFHIGGLGWALVGLANGAHNIVISDFTPESLLDTLVGERVTNVFLVPTVIGMLVDVPGAERADVGALRSIAYGSAPITPALLRRTLRTFGTPLFQVYGLTETHGAVTQLDAEDHSTDPDRAHLLRSVGRPYPWVELSIRTAWGKEAPRGEQGEICVRTPQATRGYHRRDAETAATIDPDGWLHTGDIGRIDADGYVYVTDRLKDMIITGGENVYPTEVEAVLGDHPGVAQVAVVGLPHDTWGEVVTAFVVAAPGHEATAADLRAFARARLAGYKVPKAVHVVDTLPLGATGKILKRALREQFTTPPGPAGSTPASPDQ
>NC_018581.1|WP_014928040.1|4567015_4567501_-|hypothetical-protein
MAVASLRRMLGIGKLPDDLRGEVVAEHAHHIVEFVPVTLRFSGRVPGRKAQGNVRPFTGALALTQRRVLATMSTVPGRAGRSVDCEWTAVPGSMVRARLDTDGLVIEIPALDRVDPDFSGTLSLTYTTELPSSALQLAPAREVWFDVPARYVTSLVGGRRG
>NC_018581.1|WP_014928041.1|4567527_4568409_-|LLM-class-flavin-dependent-oxidoreductase
MTMPVMEPDLDAETLHSWATTIDDGPFSSLCWGERIAFDNPECLTFLGALAAWTRRVPLVMTVVVPQLHDPVMLAKSLATGDMLSAGRLTVALGVGGRHEDYRAVGADPSTQTMRQLADRAATMKRVWAGDKLTESVLPVGPPPHRKGGPQLHVGTTGPKTIRSAVDWADGIAGVTLDLDTRKQNELFDVARSAWADAGRAAPHLATSFWFAIGDGDGPRAQVTRHLHHYMNWIPTEFVDAIAPTTGWAGTEAELTEVLRRFADIGTDEVQLIPTSSDPEQLRRAADVVAAFA
>NC_018581.1|WP_014928042.1|4568518_4569802_-|fatty-acid-desaturase
MAITDIDQYAHLTDSDVETLGAELDAIRRDIEESRGEADAKYIRRAITIQRSLAAGGRLALMFSNKKVAWAAGTAMLSLAKIIENMELGHNVMHGQWDWMNDPEVHSASWEWDTTCPSVQWKHSHNFVHHKYTNVVGMDDDVGYGILRVTRDQPWEWWNVGNPIYNLTLGTFFEYGVALHHLETEKLRSKEKTYRQAAKDLRVIGTKVGKQAAKDYLIYPVLAGPNWKTTLTANFTSNIIRNYWAYMVIFCGHFPDGAEKFTVEEFENEDQPRWYLRQMLGSANFKAGPLMRFMSGNLSHQIEHHLFPDLPSSRYEEIGVRVRELCDKYDLPYTTGTLLGQYAQSFRTIAKLALPNSLLKATSDDAPETASELRFAIREGMTDHFGVDPETGKRRGLRTALRELKNSPVRSAHVGRAASGSPGRNQN

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Crispr_ID: NC_018581_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018581_6

4732885-4733030

Orphan

Consensus_repeat	Method
CAGAGCAACACCCGCAAGCTCGCTCCTCAGGGAAACAGAGCAA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_018581_6

>merge|NC_018581|6|4732885-4733030|CRISPRCasFinder
CAGAGCAACACCCGCAAGCTCGCTCCTCAGGGAAACAGAGCAACACCCGGCCCCTCCGCTCCTCAGGGAACAGAGCATACCCGCAAGCTCGCTCCTCAGGGAACAGAGCAATACCCGCAAGCTCGCTCCTCAGGGAAACAGAGCAA

>NC_018581|6|6|4732885-4733030|CRISPRCasFinder
CAGAGCAACACCCGCAAGCTCGCTCCTCAGGGAAACAGAGCAA	CACCCGGCCCCTCCGCTCCTCAGGGAACAGAGCATACCCGCAAGCTCGCTCCTCAGGGAA
CAGAGCAATACCCGCAAGCTCGCTCCTCAGGGAAACAGAGCAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_018581.1\|WP_014928159.1\|4729851_4730667_+\|citrate-lyase	unknown	unknown	gnl\|CDD\|225184
NC_018581.1\|WP_014928156.1\|4726206_4727688_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_018581.1\|WP_014928165.1\|4737633_4738383_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NC_018581.1\|WP_014928167.1\|4738851_4739841_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NC_018581.1\|WP_010842731.1\|4724191_4724707_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NC_018581.1\|WP_014928168.1\|4739923_4741210_+\|lipase	unknown	unknown	gnl\|CDD\|367570
NC_018581.1\|WP_014928158.1\|4728517_4729669_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NC_018581.1\|WP_014928155.1\|4725623_4726115_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NC_018581.1\|WP_044507268.1\|4735704_4736892_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340897
NC_018581.1\|WP_014928164.1\|4736888_4737563_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NC_018581.1\|WP_014928166.1\|4738382_4738718_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_018581.1\|WP_014928161.1\|4731708_4732848_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|211976
NC_018581.1\|WP_014928157.1\|4727726_4728470_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_018581.1\|WP_014928170.1\|4742143_4742392_-\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014928154.1\|4724700_4725627_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187589
NC_018581.1\|WP_014928160.1\|4730659_4731664_+\|acyl-dehydratase	unknown	unknown	gnl\|CDD\|239535
NC_018581.1\|WP_014928153.1\|4723211_4724084_+\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NC_018581.1\|WP_014928162.1\|4733120_4734038_-\|ectoine-hydroxylase	unknown	unknown	gnl\|CDD\|131461
NC_018581.1\|WP_014928169.1\|4741219_4742080_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|235853
NC_018581.1\|WP_014928171.1\|4742623_4743298_+\|ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377145

Protein	Function_ID	Function_description	E-value
NC_018581.1\|WP_014928159.1\|4729851_4730667_+\|citrate-lyase	gnl\|CDD\|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	8.65529e-50
NC_018581.1\|WP_014928156.1\|4726206_4727688_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.06937e-47
NC_018581.1\|WP_014928165.1\|4737633_4738383_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	6.10006e-14
NC_018581.1\|WP_014928167.1\|4738851_4739841_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	6.74727e-34
NC_018581.1\|WP_010842731.1\|4724191_4724707_+\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	2.69404e-15
NC_018581.1\|WP_014928168.1\|4739923_4741210_+\|lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	3.43036e-40
NC_018581.1\|WP_014928158.1\|4728517_4729669_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	5.88112e-140
NC_018581.1\|WP_014928155.1\|4725623_4726115_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.45888e-09
NC_018581.1\|WP_044507268.1\|4735704_4736892_-\|MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.05502e-112
NC_018581.1\|WP_014928164.1\|4736888_4737563_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	5.91238e-50
NC_018581.1\|WP_014928166.1\|4738382_4738718_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	7.19692e-15
NC_018581.1\|WP_014928161.1\|4731708_4732848_+\|CoA-transferase	gnl\|CDD\|211976	TIGR04253, mesacon_CoA_iso, mesaconyl-CoA isomerase. Members of this protein family belong by homology to the family of CoA transferases. However, the characterized member from Chloroflexus aurantiacus appears to perform an intramolecular transfer, making it an isomerase. The enzyme converts mesaconyl-C1-CoA to mesaconyl-C4-CoA as part of the bicyclic 3-hydroxyproprionate pathway for carbon fixation.	1.11116e-101
NC_018581.1\|WP_014928157.1\|4727726_4728470_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	5.20054e-41
NC_018581.1\|WP_014928154.1\|4724700_4725627_-\|SDR-family-oxidoreductase	gnl\|CDD\|187589	cd05328, 3alpha_HSD_SDR_c, alpha hydroxysteroid dehydrogenase (3alpha_HSD), classical (c) SDRs. Bacterial 3-alpha_HSD, which catalyzes the NAD-dependent oxidoreduction of hydroxysteroids, is a dimeric member of the classical SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.64379e-47
NC_018581.1\|WP_014928160.1\|4730659_4731664_+\|acyl-dehydratase	gnl\|CDD\|239535	cd03451, FkbR2, FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The function of FkbR2 is unknown.	2.85114e-32
NC_018581.1\|WP_014928153.1\|4723211_4724084_+\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.49326e-56
NC_018581.1\|WP_014928162.1\|4733120_4734038_-\|ectoine-hydroxylase	gnl\|CDD\|131461	TIGR02408, putative_L-proline_4-hydroxylase, ectoine hydroxylase. Both ectoine and hydroxyectoine are compatible solvents that serve as protectants against osmotic and thermal stresses. A number of genomes synthesize ectoine. This enzyme allows conversion of ectoine to hydroxyectoine, which may be more effective for some purposes, and is found in a subset of ectoine-producing organisms.	2.37893e-109
NC_018581.1\|WP_014928169.1\|4741219_4742080_-\|glucose-1-dehydrogenase	gnl\|CDD\|235853	PRK06701, PRK06701, short chain dehydrogenase; Provisional.	2.48712e-136
NC_018581.1\|WP_014928171.1\|4742623_4743298_+\|ANTAR-domain-containing-protein	gnl\|CDD\|377145	pfam03861, ANTAR, ANTAR domain. ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	1.09001e-11

>NC_018581.1|WP_014928161.1|4731708_4732848_+|CoA-transferase
MSPTTRPLEGLRIVEVSSFVASPLCGLTLSQLGAEVIRVDPVGGAADVNRWPVTGEGTSIYWTGLNRGKKSVTVDFRDPQGQRTIQDLVTDSGPGGGILVTNAGGRSWMSHETLSARRSDVITLELLGRTDGTPGVDYTVNAGLGFPAITGPTDYAGVVNHALPAWDIACGLYAALAITAAVRRRDQTGAGAQITLPLEDTALAIAGTLGYLTEPQLGGGSRPGTGNDVYGTYGTDFVAADGGRFMLVALTPRHFRGLVEMTGTGDAVAAVERALDADFGREDDRFLHRGVLTPLFAAWFARHTTAEVEAELANSSVLWERYRTFGEVVESGALHRNPLFAELDQPGIGTYLAAGLPARFDGEHLFAGPAPDLGSSTGF
>NC_018581.1|WP_014928160.1|4730659_4731664_+|acyl-dehydratase
MSEPIAVGGPHFDDLAHGQIFDDAPSLTLTDGLAASHQMILGDRLRLALDAQLSTRVIGGGTLAHPGLVTDIAIGQSTLATHHVKANLFYRGLRFLSHPRIGDTLTTVTEVVGLRENTPRPGRPPTGLAALHMVTTDQHGATVLDFHRCAMLPLSPDADPERTVHADDLSTIGPGTDATPSIPEWDLETYRTSVRGEHFSPELAGRVFTSSADVVSSAPELARLSLNIAATHHDERVAGAAAGGRLVYGGHTIGLALSQANRALPNLVTVLGWDSCDHTGPVHEGDTLSSEITVAEATPLAAGGGILHLHSKVVAHGDDEDRDVLDWRYRVLMA
>NC_018581.1|WP_014928159.1|4729851_4730667_+|citrate-lyase
MAPASDDRKARKALASIADEVVLDLEDAVTPENKNSARAAAADLVAEFGADRAISLRINAIDTQWAAADLAACAQMPNLTSVVLPKADSPADLRSADEQLGRAPVRLQALLESPRGIRDAGAICAATNRLDAVLIGYADLGAALGRAPGLAMHTWHVVQDSVLLAARAAGVDVIDGPHLTIADDEAFRDAKRWVRDLGFDGTWVIHPAQLASAIEIFTPDDAAIEDARRVLDALEKAAAAGAGAAELDGRMLDEALAVAARRVLAKGGSDV
>NC_018581.1|WP_014928158.1|4728517_4729669_-|acyl-CoA-dehydrogenase-family-protein
MSTLSAEESFLVETVRSFVDREVKPSVQEVEHANEYPEKWIEQMKQIGIYGLAVPEEFGGSPVSMPCYARVTQELARGWMSLAGAMGGHTVVAKLLTLFGTEEQKRTYLPRMATGEMRATMALTEPGGGSDLQAMSTVAKEDGDELVISGSKTWISNARRSGLIALMCKTDPSATPRHKGISIVLVEHGPGLTVSRDLPKLGYKGVESCELSFDGYRAPKSAILGDVPGKGFGQMMKGLETGRIQVACRALGVATAALEDSLAYAQQRESFGQPIWKHQSIGNYLADMATKLTAARQLTWHAAEQFDRGERCDMEAGMAKLYASEVAMEIALNAVRIHGGYGYSTEFDVERYFRDAPLMIVGEGTNEIQRNVIAAQLVSRGGI
>NC_018581.1|WP_014928157.1|4727726_4728470_-|GntR-family-transcriptional-regulator
MGDAGQSEPAYKTLANELRSQIVAGKYAGGVRLPTEVELSQEYALSRQTVRRAFLELVTEGAVYRVPGRGTFATENAGQYLRQLGSIEDLMNLSTDTEMQVLESPARRVDLEAAGRLRLDTDVVYRIVFQRFHDGVPFVVTTVSWPEPVARLVIDAPEVEQGAISDHTMIGLLEPHLADPIEECAQSITATTADATTADRLGCPVGHTVLRVDRLYTDSRGRAVELAVSHFLPEHYTYRVTLRRSGI
>NC_018581.1|WP_014928156.1|4726206_4727688_+|MFS-transporter
MSRVRGATPGLTRDAAEAVDKAPAGAVGSVVVLCFGGLVASLMQTLIIPIQPDLPRLLGTSIGNASWIITATLLAAAVAMPIAGRLGDMFGKQRVLFVSAVLLTLGSLICALGDTLVPLIIGRGVQGLAMGFIPVGMSLIREITPPRITSMAVAAMSATLGVGGAIGLPLAAWIVQTWDWHALFYVATGLGVLISVAVLVLVPRVNDAVGGRIDVPGAIGLAVGLSAFLIAVSKANDWGWTSGRTLGLGLGGIAVLLVWGVFELRQRDPLVDLRTTARPAVLLTNIAAAAIGFGMMAQSIVLPMLLRLPEATGYGLGQSLLAAGLWMAPGGLMMMIFAPVSGILINRIGAKITLAIGAAILGCGYLLAFFLMDAAWKLMLASIVCAIGVGVGYAAMPTLIMGSVPATEAGAAVGLNGLMRSLGTTIASAVMALILASATISLGGTEVPDESTFTWCFLVAAAAAFVGMAITLTIPARRGSSNVPEEQPLPARH
>NC_018581.1|WP_014928155.1|4725623_4726115_-|winged-helix-turn-helix-transcriptional-regulator
MSEDHAPWQSAVHRDLAQELLRMSGRRSLVHPAAGLERSAFAILWVLSDGRPRTLRELTAELGLEQSTVNRQVNAAIKHGYVERFEVENSLSKLIRPTEEGSKAFRRDGLLRAQRLEQVFADLDPGTPQALLHELRAFNDAYERTQHRHGTTDSVDPYKKGLG
>NC_018581.1|WP_014928154.1|4724700_4725627_-|SDR-family-oxidoreductase
MTVGGTYAVTGSASGMGAAVARSLRAEGHTVIGVDRRDADVVADLSTPEGRHTAAAEVMTRAGGTLDGAVLAAGMGPAKGRERTIVEVNVLGVTELLTAWRPALAAVDNAKVVVFGSNSTTVTPLVPGGAVRRLVDGDAEGATRVIRRRRGVTGPVAYASSKIAVTHWCRLHGTAPEWAGEGIRINVIALGPVMTPLLQAQLDGPQADSVRSFPVPVREFGTPEQLAAWVMLMLSPAADFMAGAVITVDGGTEALMRARSWPRPLPVQGIPKLLWAMYRAPKKGQIARYREAAADDGRPAASSDGVVY
>NC_018581.1|WP_010842731.1|4724191_4724707_+|DoxX-family-protein
MARLFTTPRPTSNHTAAQLLLRAAIGGTMIAHGVKHARSLAGTAGWFGSIGFKQPKLQAQASAVVEIGSGAAVVAGAGTPLASAAIVGTMAVAARSVHQPNGFFITSEGWEYVANLSVAAIALAAIGPGRFSVDRALGIDTKLTSGQAAAVAAGVGLTAAGAQLALFHRPQ
>NC_018581.1|WP_014928153.1|4723211_4724084_+|siderophore-interacting-protein
MGYSRARVVDVADLTPNLRRIVFDVTDLPGLGLPGGADEAVGIYFPHEPERVTPDMECRDGTWAYYDIEPAPDGRNYSIRSVDHSAGTMVVDFVIHAAGPATLWAQRAEAGHDVVMTHARSWYAPPAGVERLVLAADLAGLPALARILDELPSTDGVTAVVEVPAPTELSYLPERDVELITLAGGNSRTPSRLADTVCGLDLPTSGAYCWFAGEAAESRAVRKHLRGDLRWDRRSYDVIGYWRVDAERWTRAYAEHGAELFAVYREALADGKSEKQASEEFDEALERAGL
>NC_018581.1|WP_014928162.1|4733120_4734038_-|ectoine-hydroxylase
MGTHTATRTPEAGHSANTSVDVYRTRLARRSQIEPRPHNTVWGSMGNPGPLSAPELRRYADRGYHTETNILADADIAACLHEVESITERLGDDERVIRESSNGDVRSLFAVHRLSDVIAEICSREAIVGVARQILDDDVTIHQSRINLKPGFAGGPFYWHSDFETWHAEDGMPAPRALSVSLALTPNYSTNGPLMIIPGSHRRFVSCVGSTPGDYHRESLTSYRPPVGTPEEEDVASLADELGIDTITGPAGSALYFDSNCLHASGGNITPYPRSNLFVVFNAKSNALQEPYGGTPPRPDHLAHR
>NC_018581.1|WP_044507268.1|4735704_4736892_-|MFS-transporter
MSGQALSAHEKTGVGVIVTAVGVMLVAANLRPAVVAVGPLIGTISDDAGFSSAVAGLLTALPVLFFGISAPVAPRLANRFGIERVIFGALLVLIVGILVRLIPSAAALFAGSAVIGAAIGTCNVVLPALIKRDFAHRSGLMTGLYSMTLSGGAAVASGVSVPINDELGGNWRLALATWALLALVAVVVWIPQLPMVHRVTSAGQATSLLKNPIAWAITVFMGTQSLIFYTFVAWLPQYLVETGMSPLRAGAVLASAQVVALIMSLLAPIVAGRFADQRAVTLSVITVCAVGFVGLLSTDVWPGFWAACVMVGPGSSISLALLFMVLRSSGSEQTGQVSGMAQSVGYLAAAAGPIVIGAIHDVTGSWTLAMAVLGLVLVPQALSVLGAAKDVKMTG
>NC_018581.1|WP_014928164.1|4736888_4737563_-|FadR-family-transcriptional-regulator
MSGQITPPRRTSELVVQRMQELITDGTWPLGERIPAEPELVAQFGVGRNTIREAARALEHAGMLEPRRGDGTYVRGRSPLAGAIARRSAPSELRDLLEVRRALESEAAAGAAGRADAADVERLRMLLARTEAALADGDLDRYTEADIAFHAEIVVASRNALLIEMYDGIAEVIARTHPSVVRGPLAEQTHPRGHRDVVDAIERGDAGAARAAVYAYVDFTEVPE
>NC_018581.1|WP_014928165.1|4737633_4738383_-|cation-transporter
MAAEPGSLSVRRPGPGAARRTLLQRRIRWFVAATIAYNVIEAVIAISEGMRVSSGALIGFGLDSVIEVSSAAAVAWQFAGSDPERREKVALRIIAISFFALAAYVGVDSVRSLVGLGDEARHSSIGIALAAVSLLVMPLLSWAERRTGRELGSLSAVADSKQTLLCTYLSAVLLVGLALNGLLGWSWADPVAALVISVIAVREGINAWRGDACCVPAIGVDGGRPAACDCCSAESSGRVTEPGARASGC
>NC_018581.1|WP_014928166.1|4738382_4738718_-|winged-helix-turn-helix-transcriptional-regulator
MESAAVAQRDALTRFGYALSDSTRTQVLLRLRSGGAFPSELADTIGVSRQVLSNHLACLRGCGLVVAVPEGRRTRYELADSKIGHALDDLLGLVLAVDPACCPASGEEGCC
>NC_018581.1|WP_014928167.1|4738851_4739841_+|ABC-transporter-substrate-binding-protein
MQPKRYLAVPFMLIAVLVFALGCSSGDDGNSGTDSAEATATTTVDHQYGSTVIDGVPKRVVTLTGATAWTDSLIKLDVPITAEFVSAGYSGPDNRFAWTPPHESTVIPVDVGASPGVAEVAKFEPDLILAGYLPDRAAYDVLAKVAPTIPVMSTETVNDTWQQVLSTAGKIFDKEDQASQAQTEVEEKIDAIKKKYPAAQDKTATFGQLTPERQFGVVTSDNDPSAKLLAEVGLRLDPAVTGLSDNGQRVVVSSERVDLLGSDLLIFWPLVGGPEVFETIPGWDSLPAVRSGATVFLTNDTASAFGTPTVYSVPWAVDALEPALAKIAS
>NC_018581.1|WP_014928168.1|4739923_4741210_+|lipase
MSFGLRTSWLRVGVIGLVVGVIAGVLASAPPAQAAPGPGSPLPSADPFYSYDASLAGVAPGAVLRSRPMQFRTPTMSTPITGSQVLYRTTDQFGASVVTVATVLRPLTPGPTRLVSYHMAYDALGSQCDPSYTLSGGYTNGTATAEQGVIAGYLAAGYTVVVPDYEGEKLQWTIGRQSGYAALDGVRAAQSFLRLPRSTPVGLVGYSGGSIPTQFGAEVAPRYAPELNIVGAAAGGLPVDLAHNLPYINGSAKWAGVIPALVVAYQRTYRLDTSTFLSARGRQVAQDVSDECISEFASKYAGLTSADMVKPPYTGLLDVPQVVRAINDNIMGRSGTPSTKMLLAVGHYNAIGDTLMITGDVIGLADEYCSRGVDITYRQLNGLTHQEAFLPFEPLALQYLTERFAGTPTHSNCGSLPRGNSLAPLPVP
>NC_018581.1|WP_014928169.1|4741219_4742080_-|glucose-1-dehydrogenase
MSDENPEHVAKTIPYPGETDEMGDRPRDEMREYRGRDLLAGKTALITGGDSGIGRAVAVAFAKEGADVAIAYLEEDNDARYTVELIEAQGRQARAYRGDLADPAHCADVVKRTVDELGALDILVNNVAYQEIVDDFMELTPEQWRRTFDVNIDSFFHTTRAAVPHLTGGGAIINTSSINGLRGNDSLIDYSATKGAVLALTYSLAQALMKRKIRVNCVAPGPVWTPLIPATMPADAVKDFGTQAPMGRAAQPDEIAPSYVFFAAEQLSSYYTGEVLAPIGGETLPG
>NC_018581.1|WP_014928170.1|4742143_4742392_-|hypothetical-protein
MSTENAGDSATAATEGINPDLTSTAGFEDLDEDRLGQDPLEEGMDPPEDWSASDRTGTTAREQREGESLDEKLDQEIPDEHP
>NC_018581.1|WP_014928171.1|4742623_4743298_+|ANTAR-domain-containing-protein
MTDANDHTAGESRISHVGSFRFLFDTQEWEWSDEVAEMHGYRPGEVTPTTELIAGHKHPDDRQSFEELLATMLDRRIPFSSRHRIVDTEGQVRHVAVVSQQLTDESGTVIGAEGFYLDLTAIEEKAVKDRVDEHVARFREHQGVIEQAKGMISLAYGVSADRAFEVMRWRSQTANVKVNELARSIVTGVHKYVVLPDPVRQSFDHLLLNAHQTDNQSSPHSNSH

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Crispr_ID: NC_018581_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018581_7

5201000-5201238

Orphan

Consensus_repeat	Method
CCGCTCCCTGAGGTGCGAGGAGCGTAAGCGACGAGCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_018581_7

>merge|NC_018581|7|5201000-5201238|CRISPRCasFinder
CTGCTCCCTGAGGTGCGAGGAGCGATAGCGACGAGCCACGAAGGGCCCAGTGAGACACGTCGCCAACCCTTCGTGGCTCGCTTCGCTCGCACCTCAGGGAGCAGTAAAGGCGTCCCCTCCGCTCCCTGAGGTGCGAGGAGCGTAAGCGACGAGCCCACCCCCGCTCCCTGAGGTGCGAGGAGCGTAAGCGACGCGCCCACCCCCGCTCCCTGAGGTGCGAGGAGCGTAAGCGACGAGCC

>NC_018581|7|7|5201000-5201238|CRISPRCasFinder
CTGCTCCCTGAGGTGCGAGGAGCGATAGCGACGAGCC	ACGAAGGGCCCAGTGAGACACGTCGCCAACCCTTCGTGGCTCGCTTCGCTCGCACCTCAGGGAGCAGTAAAGGCGTCCCCT
CCGCTCCCTGAGGTGCGAGGAGCGTAAGCGACGAGCC	CACCCCCGCTCCCTGAGGTGCGAGGAGCGTAAGCGACGCGCCCACCC
CCGCTCCCTGAGGTGCGAGGAGCGTAAGCGACGAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018581.1\|WP_010844460.1\|5208492_5209764_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173838
NC_018581.1\|WP_014928554.1\|5205896_5207198_+\|DUF4185-domain-containing-protein	unknown	unknown	gnl\|CDD\|379383
NC_018581.1\|WP_014928548.1\|5201246_5201819_-\|YdeI/OmpD-associated-family-protein	unknown	unknown	gnl\|CDD\|226851
NC_018581.1\|WP_014928545.1\|5196365_5197175_+\|bacteriocin-family-protein	unknown	unknown	gnl\|CDD\|377362
NC_018581.1\|WP_014928551.1\|5203431_5204343_-\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240636
NC_018581.1\|WP_014928542.1\|5191974_5193453_+\|amidase	unknown	unknown	gnl\|CDD\|223232
NC_018581.1\|WP_014928539.1\|5187344_5188712_+\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|223733
NC_018581.1\|WP_014928538.1\|5186082_5187126_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176186
NC_018581.1\|WP_010844458.1\|5207194_5207722_+\|DUF1697-domain-containing-protein	unknown	unknown	gnl\|CDD\|377954
NC_018581.1\|WP_044507393.1\|5201865_5202564_+\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_010844459.1\|5208002_5208479_-\|hypothetical-protein	unknown	unknown	unknown
NC_018581.1\|WP_014928546.1\|5197307_5199041_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_018581.1\|WP_014928552.1\|5204339_5204834_-\|ribonuclease-HI	unknown	unknown	gnl\|CDD\|178927
NC_018581.1\|WP_014928543.1\|5193526_5195200_+\|FAD-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|183782
NC_018581.1\|WP_014928547.1\|5199037_5200957_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_018581.1\|WP_014928553.1\|5204947_5205715_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|226591
NC_018581.1\|WP_010844453.1\|5202564_5203356_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181131
NC_018581.1\|WP_014928541.1\|5190571_5191537_-\|esterase-family-protein	unknown	unknown	gnl\|CDD\|223700
NC_018581.1\|WP_014928540.1\|5188811_5190164_+\|DUF3068-domain-containing-protein	unknown	unknown	gnl\|CDD\|371444
NC_018581.1\|WP_044507392.1\|5195305_5196301_+\|Dyp-type-peroxidase	unknown	unknown	gnl\|CDD\|367887

Protein	Function_ID	Function_description	E-value
NC_018581.1\|WP_010844460.1\|5208492_5209764_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	2.47812e-102
NC_018581.1\|WP_014928554.1\|5205896_5207198_+\|DUF4185-domain-containing-protein	gnl\|CDD\|379383	pfam13810, DUF4185, Domain of unknown function (DUF4185).	3.03411e-132
NC_018581.1\|WP_014928548.1\|5201246_5201819_-\|YdeI/OmpD-associated-family-protein	gnl\|CDD\|226851	COG4430, COG4430, Uncharacterized protein conserved in bacteria [Function unknown].	3.7303e-26
NC_018581.1\|WP_014928545.1\|5196365_5197175_+\|bacteriocin-family-protein	gnl\|CDD\|377362	pfam04454, Linocin_M18, Encapsulating protein for peroxidase. The Linocin_M18 is found in eubacteria and archaea. These proteins, referred to as encapsulins, form nanocompartments within the bacterium which contain ferritin-like proteins or peroxidases, enzymes involved in oxidative-stress response. These enzymes are targeted to the interior of encapsulins via unique C-terminal extensions.	5.20667e-121
NC_018581.1\|WP_014928551.1\|5203431_5204343_-\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240636	cd12159, 2-Hacid_dh_2, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	1.86431e-128
NC_018581.1\|WP_014928542.1\|5191974_5193453_+\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	5.19279e-121
NC_018581.1\|WP_014928539.1\|5187344_5188712_+\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	4.39456e-117
NC_018581.1\|WP_014928538.1\|5186082_5187126_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176186	cd05283, CAD1, Cinnamyl alcohol dehydrogenases (CAD). Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NC_018581.1\|WP_010844458.1\|5207194_5207722_+\|DUF1697-domain-containing-protein	gnl\|CDD\|377954	pfam08002, DUF1697, Protein of unknown function (DUF1697). This family contains many hypothetical bacterial proteins.	4.21609e-42
NC_018581.1\|WP_010844453.1\|5202564_5203356_-\|SDR-family-oxidoreductase	gnl\|CDD\|181131	PRK07814, PRK07814, SDR family oxidoreductase.	3.02948e-143
NC_018581.1\|WP_014928546.1\|5197307_5199041_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.13753e-159
NC_018581.1\|WP_014928552.1\|5204339_5204834_-\|ribonuclease-HI	gnl\|CDD\|178927	PRK00203, rnhA, ribonuclease H; Reviewed.	2.23462e-90
NC_018581.1\|WP_014928543.1\|5193526_5195200_+\|FAD-binding-dehydrogenase	gnl\|CDD\|183782	PRK12834, PRK12834, putative FAD-binding dehydrogenase; Reviewed.	0
NC_018581.1\|WP_014928547.1\|5199037_5200957_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_018581.1\|WP_014928553.1\|5204947_5205715_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|226591	COG4106, Tam, Trans-aconitate methyltransferase [General function prediction only].	1.91672e-83
NC_018581.1\|WP_014928541.1\|5190571_5191537_-\|esterase-family-protein	gnl\|CDD\|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	1.14066e-46
NC_018581.1\|WP_014928540.1\|5188811_5190164_+\|DUF3068-domain-containing-protein	gnl\|CDD\|371444	pfam11271, DUF3068, Protein of unknown function (DUF3068). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	1.11816e-87
NC_018581.1\|WP_044507392.1\|5195305_5196301_+\|Dyp-type-peroxidase	gnl\|CDD\|367887	pfam04261, Dyp_perox, Dyp-type peroxidase family. This family of dye-decolourising peroxidases lack a typical heme-binding region.	1.20693e-109

>NC_018581.1|WP_014928547.1|5199037_5200957_+|ABC-transporter-ATP-binding-protein
MTRPGGPPMAAGPESKPRSFWPSVKRVVAQLASYRMLMTVTLASLVGSVVLIAIAPRVLGYATDLVFDGVIGRTLPEGLTKEQAVAGLRESGDDTFADMVSSMDVTPGVGVDFGEVGRVLLITLALYVVSSLLAWLAGYLLNIVVVGTIRRLRDDVEAKVHRLPLRYYDTMPRGELLSRVTNDLDNLSQSMQQTISQFANSVLTVIALLIMMIWISPLLALIAVATVPLAIIATGVIAKRSKPHFSAQWSSTGALNAQVEEAFTGHELVTAFGRQREIQTTFDERNQKLYESSWRAQFISGVIMPTIMFLGNLNYVAVAVVGGLRVASGSLSLGEVQAFIQYSRQFTQPLTQIGSMINLMQSGVASAERIFDILDADEQSPDAASPKTPTDDKGLIEFDDVSFRYVEDKPLIENLSLVARPGHMVAIVGPTGAGKTTLVNLIMRFYDVDSGVICVDGVDSTQMTRDDLRERTGMVLQDSWLFGGTIYENIAYGDPTASREEVLDAARMSHVHHFVRTLPDGYDTVLDDEGGGVSAGERQLITIARAFLARPTILILDEATSSVDTRTELLIQKAMANLRSDRTSFVIAHRLSTVRDADVIVVMEDGHIVEQGSHDELLAARGAYCRLYESQFTGAIEAT
>NC_018581.1|WP_014928546.1|5197307_5199041_+|ABC-transporter-ATP-binding-protein
MLTRLIRTYLARYRINVVLVIVLQLLATTAMLFLPSLNADIIDNGVARGDTGYILRIGGWMLLVSVAQIIVTVAAQFFGSRAALGVGRDIRGDLLHRVNSFSAREVGTFGAPSLITRTTNDVQQVQMLIVMSSAILVMAPIMCIGGIIMGVREAPALSWVIAIAVPVLGVSMGAIIAKMIPGFRAMQERIDNVNRVLREQITGIRVVRAFVREDYERRRFAVANDDLADATLHVGRLMALMFPVVMVITNVTIVAVIWFGGHAVSDGSLEIGALTAVMSYVMQILMSVMMASFLAMMAPRAAVCAERISEVLATDTSVHPPSEPIGFATHPGMVEFDAAEFRYPGADDPVLSGIDFRVEPGTTTAIVGSTGSGKTTLVGLVPRLIDTTSGAVRVGGTDVKRLDPDELRSVVGLVPQRPYLFSGTVRSNLLHGKADATDDEIWEALRIAQAEDFVSAMPDGLDTKVSQGGTTVSGGQRQRLAIARALIRRPAIYLFDDSFSALDLTTDARLRAALRPATREAAVIVVAQRISTIIDAEQIVVLDRGRIVGLGTHDDLRQSCPTYAEIVESQMAMEERA
>NC_018581.1|WP_014928545.1|5196365_5197175_+|bacteriocin-family-protein
MNNLHRELAPISDAAWAEIEEEATRSFKRNVAGRRLVDVTGPLGSDTASVTLGHRTKIDSPAQGITAFQRRTQSLVELKVPFTVSREAIDDVDRGAKDSDWDPVVDAARELALAEDRAIFEGYTAASINGIRAEASASPIPLPTDVRDYPEAVSQALSTLRLASVDGPYAVALSAEAYTQVNETSNHGYPILEHIQRLFTGDIVWAPAISGAFVMSTRGGDFELTIGQDVSIGYDSHDGDVVNLYFQESFTFLTHTAEAAVALTEPPTV
>NC_018581.1|WP_044507392.1|5195305_5196301_+|Dyp-type-peroxidase
MPVPQTILTRKTKSAIFLVFTIDDGGEDAVRDALEEIPGLNNAVSSRAPEAALAGIVSIGSAAWDRLFAGPRPRSLRPFVPYEGEVHTAPATPGDLLVHIKSDDMGLCYELGAKITESFGGAVTVVDEVHGFRYFDLRDLIGFVDGTENPTGQAAIDAITVGAEDPDFAGGSYVAIQRYVHDLSSWNDLSTEEQEAAIGRTKLDNVEMSDEVKPPNSHIALNVVEDENGEEIDVVRDNMPYGDVSGTGVNGTFYIAYSAAPDVTEEMLRKMFIGDPPGTYDRLLDFTTAVTGSQFFTPTLDFLEELPPAPDAAPPSPTTRSDGSLGIGSLH
>NC_018581.1|WP_014928543.1|5193526_5195200_+|FAD-binding-dehydrogenase
MAENEADAVVVGAGLAGLVATYELTKAGRRVVVVDQENRNNLGAQAFWSLGGLFMVDTPEQRRLGISDSADLALQDWMGSAGFDRDDEDYWPRQWARAYVDFAATEKRQYLHDLGLRITPIVGWAERGGGFADGHGNSVPRFHVTWGTGPEVVRVFAEPVLEAEKRGLVEFRFRHRVDELVVDDGTAVGVRGVTLAPTDAERGRASNRDVVGDFEIRAGSVIVTSGGIGHNHDLIRKNWPVDRLGPAPQTMISGVPAHVDGRMLEITESAGANIVNRDRMWHYTEGIHNWDPIWPDHAIRIIPGPSSLWLDANGNRLAPPNFPGFDTNSTMKAILSAGHDYSWFILTQTIVEKEFMLSGSEQNPDITEKDLKLTAKSRLAKGASGPVDAFVRNGVDFVVADNLPELVAGMNKIARGPELDLAEIERIISARDAEIGNKFSKDAQLMAITNARQYLGDKIVRVAKPHRLLDPEHGPLIAVRLNVLTRKTLGGLETNLDSQVLRPDGSAFDGLFAAGEVAGFGGGGVHGYNALEGTFLGGCIFSGRAAGRAVARATPRS
>NC_018581.1|WP_014928542.1|5191974_5193453_+|amidase
MGEYLSCDATTLAGLVASGEVTAAELLDLARTRADAVDPSLNAIVIRMDAEADARVRGALTGPFAGVPFLIKDLAQDYRGYPTTRGSRALASHIAREHSFGVRRFLDAGLVIFGKTNTPEFGAKAITEPTFWGPARNPWDLDATPGGSSGGSAAAVAAGIVPAAGASDGGGSIRIPAACTGLFGLKSSRGLMPFGPQTGEPLFGMGVEGVVTRTVRDAAALYDALIGPTPSSTYPTPLHTESYTARIATSPRLLRIGYTTTSAINGNPHPEAVAAVEHAAAVLTDLGHNVEEVDPPHDDAALARDFLDIWFAKCAAQVDEVRRLTGAPDSHFEADTLTLAELGRAAGVVPLFSALDRINDHVLALDRFHQTHDLLLTPTLAVPPPRVGSMTTPPALQLAARLASRARSGRAISRLGIIDKLVYESLGWVPYTQLANLTGRPAMSVPLHWTAAGLPLGVQFVGRLGADGDLLALAAGLEAAAPWFHRYADIVL
>NC_018581.1|WP_014928541.1|5190571_5191537_-|esterase-family-protein
MLTRARKRLVAGLVALVAVSGATLVAAPPEASAANGCNVEYVRSNAMNRTVPVCIVSAGGGGPKPTLYLLDGLRAPANNSGWLINTDVARYMAGKGTNVAIPFGGAGSFYTDWQTRDPKLGVNKWETFLTRELPGYMAARHGSDNRRNGIAGLSMSGTSALNLASRHPNFYKAVASYSGYPTVTLPGFTQGIMASVAEVGGNPFNMWGFFPAGTWFQNDPFLSAGNLAGKNVYVSSGSGVGSKYDSSVNPASSNFDPVKFAQMIPLEVAASTSSQLYIGRLALVPGVKLTTRITPDGAHWWDYWQSTFKESWAKTFRPAFF
>NC_018581.1|WP_014928540.1|5188811_5190164_+|DUF3068-domain-containing-protein
MRRFVPAVLAFFGAACIAAAIAIPLYLVPQLKVVPLDLDITSDATTVAADGSTGERFPAVIFDRCSVSENRARTLEAHLTQQRRSIIIEPSDSRQASLQSAQTVRIDRLRDAEGTETEPTVAAEGETRTCEDGLLTATIDRVSVNRKTSAPNGAVSSLQLEAVPEGGNVNDVSVAIDNRTGYQYKFGFDVQQRDYPYYDLNTRQDCAAKFEGEETIDGVNTYHFVCDVPETDLSNLPNAQGEAALGTMLTMPARWWGITGRGVRANDPITMHRYAAATRHVWVEPETGTIVDGREDQHQYFKSPDQSDATPEAVREFRMDALKGTFKWTDDTVSNQAGKASGYVDQLKVGGVWVPIILGIVGAILLIAALLLFFRGRRDDTRVDDTPPPTAPPADERDTTLIKRDAPPAGAAPAGANPWERPTEQIPKVGDTPPADDSATRTFRKQPPPE
>NC_018581.1|WP_014928539.1|5187344_5188712_+|AarF/ABC1/UbiB-kinase-family-protein
MTINSSVDDGQRTQLHPVSPIAELSRFGTTTAHAAAGVGRFVLHTAGDALRGRAPGSARVAHEIRTTFEHLGPTYVKLGQLIASSPGVFSESMSAEFESLLDRVKPADPALMREQFIAELGRAPEEVFATFDPVPIASASIAQVHTATLPGGEEVVVKIQRPGIADRLAPDVAILERLAGLAEISEYGRMLSARHVVEDFAAGLDAELDFRIEADTMREWFACLQPGPFGDRVRVPHVYDDYTTQRVLTMERIHATRIDDAAAVRAAGHDGVALCRNLLLSLLESAFHGGLFHGDLHAGNVLVDDAGKLVLLDFGIVGRFTPRTRRILRQLVVDLVVRGDYESAGRAIFLLGAVHKPGSTSQGAEDIKKVTTPLSTTDLGSMSYTDLGRQLAAVAKAHDARLPRELVLVGKQLLYVEKYTKLLAPRWKAMSDKEIYGYMAGILKEAERDRRADRR
>NC_018581.1|WP_014928538.1|5186082_5187126_-|NAD(P)-dependent-alcohol-dehydrogenase
MPTTVNAYTAPAADRPLEPTTIERRDLGPNDVSIDIAFAGICHSDIHTARDEWGGTRFPVVPGHEIAGTVAAIGDEVTRYAVGDRVGVGCFVDSCRECEPCRLGEEQYCERGNVGTYNAVGRDGTPTQGGYSTSIVVDENYVLRIPDGIALDEAAPLLCAGITLYSPLRHWGAGPGKKVAIVGLGGLGHVGVKIAHALGAEVTVLSQSLKKMEDGLRLGADHYHATSDPQTFRELRNTFDLILNTVSANLPIAKYLGMLALDGTMVELGLPEHPIDVPAGALVGKRRSFAGSMIGGIAQTQEMLDFCAEHGIGAEIEVISADRINEAYDRVVASDVRYRFVIDTSTL
>NC_018581.1|WP_014928548.1|5201246_5201819_-|YdeI/OmpD-associated-family-protein
MADPDAPKLTVETVDAWREWLRDNHETSPGVWLVFWRKGSGREPIDYDECVREALCWGWIDGHTRVIDEQRRGMWFTRRGRNSGWSASNKARVADLAAAGRIQPAGQAVIDDAQARGLWTLFDDAEALIESPELAAALDADPAARANWDAFPPSARKFGLSQIALAKRPETKTKRIAGLVERAARNERPS
>NC_018581.1|WP_044507393.1|5201865_5202564_+|hypothetical-protein
MNEIVNFATDNWWLIFPIGAVVGGWAGSIGKYNEKRRRDKIELARIKATAQSEQLKLTTTSADQLRRVLGQHDALNEKWFAYELDLATLIEYPLMTDMREPLTLAFHRARVRADDLRPDPAAADLSTAATSMSPADFAEYRDAVGDYAAAFDAAEREARRRKQSGFSPVEREALDRARKLINVAADAGATPAERQAAYKKVRAELDGIIDVPQVAAAHLEQQIAGALERGSD
>NC_018581.1|WP_010844453.1|5202564_5203356_-|SDR-family-oxidoreductase
MILDRFRIDDQVAIVTGASRGLGAAIAVAFAEAGGDVVIAARSESDLEQVAERVRAAGRRAHTVAVDLADPDAAAALAQTAVDEFGRLDTVVNNVGGAMPRPLFDTSPKHLRDAFDFNVGNAHALVVAGAKQILATSGQGSIINITSAVGRLPGRAYAAYGTAKAALAHYTRIAAMDLNPKIRVNGIAPGAILTSALEIVAGDEGMRSAVETSTPLHRLGDPEDIAAAALYLASPAGAYVTGKILEVDGGIIAPNLDLPIPDL
>NC_018581.1|WP_014928551.1|5203431_5204343_-|2-hydroxyacid-dehydrogenase
MTPVAVALEPVRDEHLVEAIEGAGGRIVGLDDARVLVWIGPPSDFPELPDTVEWVALKTAGIEDFVAADILDDRRIWTNASGFYAENVAEHALALLLAGLRQINTAVLRHWDKERIDTAVRSLHGSTVAIVGAGGIGASLAPRLRACGARVVAVNRSGREVPGAHEVRRSDELVDLWATIDHVVLAAPATPETRHMINADSLAALPAHAWVVNIARGPLVDEEALYRALADGQIAGAALDVTDPEPPAEDHPLWSLPNVIITPHVANPASGLTRELAPWVAENLRRFAADEDLLSVVTVGRDY
>NC_018581.1|WP_014928552.1|5204339_5204834_-|ribonuclease-HI
MTASANPTADGSSADPGAGSDVVEISTDGACLGNPGPGGWGAVLRYKGTEKRISGSEPDTTNNKMELTAAIEGLAALTRPSNVVIYTDSTYVRNGIMKWVNGWQANGWKTKDRKPVKNADLWRRLVEEEKRHQVEWRWVKGHAGDHFNEIADELATTAARSVAR
>NC_018581.1|WP_014928553.1|5204947_5205715_+|methyltransferase-domain-containing-protein
MAVWDPTRYLQFADDRARPFLDLIAQIPTNPLSVVDLGCGPGHLTKHLRALWPAAEILGIDDSAEMVDRAIRDNTDPRANYDAVDVSQWAPHRPVDLMISNAMFQWVPDHLGVIDRLLGYLTDGGAFALQVPNNTDSPTHAALAELAVTEPYVGAFGDLRGLPRLDAEVYLDFFAERGYHVNAWETTYFHVLDGQDPVFDWMSGTGARPYLQALTDDLRKRFIADLKERFAEAYPRREWGTVLPFRRTFVVATHR
>NC_018581.1|WP_014928554.1|5205896_5207198_+|DUF4185-domain-containing-protein
MPRRSRTRLRPAHHVRRRVIATIAAVGLAGGLLAAVPAPARAAVCNVTGITGGDVGSTGSSGSSELGWGSLDFGSYRAGGKKPQGPLPKLTGASKAVSWVTGPRSPARTDTRFGITATDVGVPWDNGSGQILMAFGDTWGKCAGQMAWKHNTMLRSDANSDLAKGIRFPNAVPGSVRSGASVSSAHPTWAQPMFNAVGVRNIEVGRIPTGGISVNGTQFVSFMSIHRWLGPGRWSTNYSGIALSHNNGQTWTVDNNTLRWNTDLTIPGVPQVASGHNRFQMGAFLRSGEYIYQYGTPNGRFGSAHVARFRPADILNLNRYQYFRGGTSWSSNPAEAAPIVAGPVGEISVAYNAFLGRFVMLTERAGTIMMRTSPSPVGPWSGERVLISQRQSSGLYTPYIHPRSSGEDLYFVVSRWDDYNVMLVRTDLSKVRP
>NC_018581.1|WP_010844458.1|5207194_5207722_+|DUF1697-domain-containing-protein
MSRRIVLIRAVNVGGAKLPMAELRQIATDLGADEVTTYIASGNLICSPPPDPDEFDRALETAMEERYGWFREVISRTTDQVRAALDAHPFDIVDDKYSYVYFLTGEPAPDKVTAFERKDFGEDVVRVIGSDLHIRYADGAGRSTLTAPVIARGLGVQGTGRNLRTVRKLLELAGS
>NC_018581.1|WP_010844459.1|5208002_5208479_-|hypothetical-protein
MIAVIIIVATVVVALFILGGAAWFAYDSDKRVRTFARSTDLIPGRPGRAPDSWATDNTREALLHRRIRYAIADVHANPAIPHDDELVAARNRLDDAVFELDDRLIASVDLGEDEATEALDHAEAAVKDLEKLPKKLWEAPREEQLADLDRVARVLTRG
>NC_018581.1|WP_010844460.1|5208492_5209764_-|acyl-CoA-dehydrogenase-family-protein
MDFALPESLKDYLAELDAFIEAEIVPLEQADDNIRFFDHRREDSRTDWERGGLPNKEWEALLGEARRRADAAGHFRYPFPAEFGGRDGSNLAMAIIREHLASKGLGLHCDLQNEHAIVGNNIGLLLMLEYGTPAQQEEWVEGLAAGTKFFAFGITEPDHGSDATYMETTAVRDGDDWIINGEKTWNTGIHAAHRDIVFARTSGEPGDARGITAFLVDPQDPGFAVEEYLWTFNMPTDHAHISLRDVRVPDSAVFGAEGAGLQVVQHFFNENRIRQAASSLGAAQYCVDRAVAYANERAPFGKKLSTNQAIQFPLVDLHTRCAMIRALIRETAWKMDTHGPFAASAEVSMCNYQANRLCCDAADQAMQVFGGRGYSRHEPFEHIYRHHRRYRITEGADEIQMRRVAGYLFGFMSGKAPKGVQSS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_018581_2	2.1\|906702\|31\|NC_018581\|CRISPRCasFinder	906702-906732	31	NZ_CP017782	Rhodobacter sp. LPB0142 plasmid pEJ01, complete sequence	40862-40892	6	0.806
NC_018581_2	2.1\|906702\|31\|NC_018581\|CRISPRCasFinder	906702-906732	31	NC_012809	Methylorubrum extorquens AM1 plasmid p2META1, complete sequence	17987-18017	7	0.774
NC_018581_2	2.1\|906702\|31\|NC_018581\|CRISPRCasFinder	906702-906732	31	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	735338-735368	7	0.774
NC_018581_4	4.1\|2770350\|29\|NC_018581\|CRISPRCasFinder	2770350-2770378	29	NC_013855	Azospirillum sp. B510 plasmid pAB510a, complete sequence	256843-256871	7	0.759
NC_018581_2	2.1\|906702\|31\|NC_018581\|CRISPRCasFinder	906702-906732	31	NC_022043	Paracoccus aminophilus JCM 7686 plasmid pAMI5, complete sequence	282968-282998	8	0.742

1. spacer 2.1|906702|31|NC_018581|CRISPRCasFinder matches to NZ_CP017782 (Rhodobacter sp. LPB0142 plasmid pEJ01, complete sequence) position: , mismatch: 6, identity: 0.806

tccatcgcgcggatccgtgccgacaccgcct	CRISPR spacer
gctatcgcgcagatccgtgccgacatcgctc	Protospacer
 *.*******.**************.***..

2. spacer 2.1|906702|31|NC_018581|CRISPRCasFinder matches to NC_012809 (Methylorubrum extorquens AM1 plasmid p2META1, complete sequence) position: , mismatch: 7, identity: 0.774

tccatcgcgcggatccgtgccgacaccgcct	CRISPR spacer
tccatcgcgccggtccgtgccgacaagaacc	Protospacer
********** *.************  . *.

3. spacer 2.1|906702|31|NC_018581|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 7, identity: 0.774

tccatcgcgcggatccgtgccgacaccgcct	CRISPR spacer
acccccgcgcagatccgcgccgacaccgacg	Protospacer
 ** .*****.******.********** *

4. spacer 4.1|2770350|29|NC_018581|CRISPRCasFinder matches to NC_013855 (Azospirillum sp. B510 plasmid pAB510a, complete sequence) position: , mismatch: 7, identity: 0.759

tcgaagggtcccgacaccgaccctctgcc	CRISPR spacer
gccgccggtcccgacaccgacccgcggcc	Protospacer
 * .  ***************** * ***

5. spacer 2.1|906702|31|NC_018581|CRISPRCasFinder matches to NC_022043 (Paracoccus aminophilus JCM 7686 plasmid pAMI5, complete sequence) position: , mismatch: 8, identity: 0.742

tccatcgcgcggatccgtgccgacaccgcct	CRISPR spacer
gaggtcgcgcagatccgcgccgacaccggcc	Protospacer
   .******.******.********** *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1517819 : 1568953

Gordonia_phage(96.77%)

integrase

attL 1517766:1517807|attR 1570506:1570547

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1517766:1517807	attL	NA	NA	NA	NA
WP_014925904.1\|1517819_1519079_-\|integrase	tyrosine-type recombinase/integrase	A0A142K9J8	Gordonia_phage	7.5e-221	90.2
WP_014925905.1\|1519092_1519320_-	DUF3263 domain-containing protein	A0A142K9J9	Gordonia_phage	6.8e-32	92.0
WP_044506183.1\|1519316_1519742_-	hypothetical protein	A0A142KCL6	Gordonia_phage	4.8e-71	94.3
WP_014925907.1\|1519792_1520329_-	hypothetical protein	NA	NA	NA	NA
WP_148281159.1\|1520353_1521262_-	hypothetical protein	NA	NA	NA	NA
WP_193363234.1\|1521265_1522012_-	helix-turn-helix transcriptional regulator	A0A1B3AZ78	Gordonia_phage	1.3e-18	35.6
WP_044506186.1\|1522270_1522519_+	helix-turn-helix transcriptional regulator	A0A1B3AZ84	Gordonia_phage	2.5e-19	68.4
WP_044506188.1\|1522518_1522800_+	hypothetical protein	NA	NA	NA	NA
WP_148281160.1\|1522862_1523672_+	phage antirepressor KilAC domain-containing protein	A0A2P1N364	Mycobacterium_phage	4.2e-47	65.6
WP_014925912.1\|1523668_1523980_+	hypothetical protein	A0A142K9K9	Gordonia_phage	2.0e-29	78.4
WP_044506190.1\|1523976_1524180_+	hypothetical protein	A0A142K8T8	Gordonia_phage	3.7e-21	72.7
WP_014925913.1\|1524265_1524604_+	hypothetical protein	A0A142K9L2	Gordonia_phage	3.9e-55	97.3
WP_014925914.1\|1524607_1525468_+	DUF2303 family protein	A0A142KCN1	Gordonia_phage	3.9e-144	89.4
WP_044506194.1\|1525756_1525999_+	hypothetical protein	A0A0U3TFJ5	Gordonia_phage	6.0e-34	77.5
WP_148281161.1\|1525995_1526325_+	hypothetical protein	A0A1B3AYV6	Gordonia_phage	4.3e-35	63.1
WP_083888942.1\|1526246_1527152_+	PD-(D/E)XK nuclease-like domain-containing protein	A0A142K9L8	Gordonia_phage	2.0e-143	89.9
WP_014925916.1\|1527148_1528237_+	hypothetical protein	A0A142K9L9	Gordonia_phage	1.8e-149	80.1
WP_044506200.1\|1528229_1528706_+	hypothetical protein	A0A142K8U5	Gordonia_phage	2.0e-09	59.6
WP_044506202.1\|1528702_1528888_+	hypothetical protein	A0A142K8U6	Gordonia_phage	2.1e-23	91.2
WP_014925918.1\|1528888_1529236_+	DUF3850 domain-containing protein	A0A142KCX5	Gordonia_phage	4.8e-53	88.7
WP_044506204.1\|1529232_1529589_+	hypothetical protein	A0A142KC64	Gordonia_phage	4.1e-15	39.4
WP_044506206.1\|1529585_1529924_+	hypothetical protein	A0A1B3B005	Gordonia_phage	5.0e-55	84.4
WP_049942580.1\|1529920_1531453_+	DNA cytosine methyltransferase	A0A2H4PEU2	Gordonia_phage	5.3e-293	95.1
WP_014925920.1\|1531476_1532190_-	hypothetical protein	NA	NA	NA	NA
WP_148281162.1\|1532654_1533302_+	hypothetical protein	A0A142K8V3	Gordonia_phage	4.6e-73	73.8
WP_044506210.1\|1533298_1533574_+	hypothetical protein	A0A142KCY0	Gordonia_phage	1.4e-23	61.5
WP_148281256.1\|1533588_1534107_+	adenine methyltransferase	A0A142KAC0	Gordonia_phage	7.4e-74	78.3
WP_148281163.1\|1534294_1534495_+	hypothetical protein	A0A142KCP8	Gordonia_phage	1.7e-34	92.4
WP_044506215.1\|1534494_1534725_+	hypothetical protein	A0A1B3AYR1	Gordonia_phage	9.1e-16	61.9
WP_044506218.1\|1534721_1535090_+	hypothetical protein	NA	NA	NA	NA
WP_014925923.1\|1535086_1535884_+	hypothetical protein	A0A166Y0V7	Gordonia_phage	6.5e-53	56.9
WP_014925924.1\|1535880_1536252_+	hypothetical protein	A0A142KB25	Gordonia_phage	3.3e-47	72.7
WP_014925925.1\|1536248_1537130_+	hypothetical protein	A0A142KC75	Gordonia_phage	1.7e-102	66.8
WP_014925926.1\|1537218_1537572_+	hypothetical protein	A0A142KC76	Gordonia_phage	6.1e-35	60.6
WP_044506223.1\|1537732_1537987_+	hypothetical protein	A0A142KC77	Gordonia_phage	6.3e-34	81.0
WP_014925927.1\|1538166_1538493_+	hypothetical protein	A0A142K8P3	Gordonia_phage	1.5e-11	39.0
WP_148281164.1\|1538539_1540033_+	hypothetical protein	A0A1B3AZE0	Gordonia_phage	5.3e-104	44.6
WP_148281257.1\|1540169_1541483_+	DUF935 family protein	A0A142KC09	Gordonia_phage	2.9e-167	75.5
WP_014925930.1\|1541482_1542982_+	hypothetical protein	A0A142KC10	Gordonia_phage	3.7e-150	67.6
WP_014925931.1\|1542983_1543430_+	hypothetical protein	A0A142KAF1	Gordonia_phage	4.3e-54	79.3
WP_014925932.1\|1543458_1544391_+	hypothetical protein	A0A142KC12	Gordonia_phage	3.8e-153	84.5
WP_014925933.1\|1544387_1544798_+	hypothetical protein	NA	NA	NA	NA
WP_014925934.1\|1544797_1545010_+	hypothetical protein	A0A0F6WE52	Mycobacterium_phage	2.2e-16	63.1
WP_014925935.1\|1545013_1545406_+	hypothetical protein	A0A142KC14	Gordonia_phage	4.1e-40	65.1
WP_044506226.1\|1545405_1545729_+	hypothetical protein	A0A142KC15	Gordonia_phage	4.9e-23	51.4
WP_049942581.1\|1545731_1546112_+	hypothetical protein	A0A142KC16	Gordonia_phage	4.4e-31	57.0
WP_148281165.1\|1546108_1546387_+	hypothetical protein	A0A142KC17	Gordonia_phage	3.1e-18	54.3
WP_044507735.1\|1546478_1547021_+	hypothetical protein	A0A142KC18	Gordonia_phage	8.3e-100	95.0
WP_044506230.1\|1547023_1547386_+	hypothetical protein	A0A142KC19	Gordonia_phage	2.8e-11	62.9
WP_044507743.1\|1547467_1547770_+	hypothetical protein	A0A142KC20	Gordonia_phage	2.2e-17	49.5
WP_014925939.1\|1547778_1548252_+	hypothetical protein	A0A142KC21	Gordonia_phage	8.7e-37	57.4
WP_158409764.1\|1549571_1553219_+	transglycosylase family protein	A0A142KC22	Gordonia_phage	2.3e-254	57.4
WP_014925941.1\|1553223_1554285_+	hypothetical protein	A0A142KC23	Gordonia_phage	3.8e-173	79.3
WP_049942582.1\|1554286_1555981_+	hypothetical protein	A0A142KC24	Gordonia_phage	3.0e-281	81.7
WP_014925943.1\|1555995_1556439_+	hypothetical protein	A0A142KC25	Gordonia_phage	1.1e-52	69.7
WP_044506235.1\|1556435_1557539_+	hypothetical protein	A0A142KC26	Gordonia_phage	3.2e-183	82.2
WP_044506237.1\|1557540_1559307_+	hypothetical protein	A0A2P1A0Q0	Gordonia_phage	5.6e-206	71.4
WP_044506239.1\|1559306_1559621_+	hypothetical protein	A0A1B3AZX3	Gordonia_phage	9.5e-40	80.7
WP_014925946.1\|1559638_1560352_+	M15 family metallopeptidase	A0A142KB50	Gordonia_phage	1.9e-80	64.3
WP_014925947.1\|1560351_1561266_+	hypothetical protein	A0A1B3AZ04	Gordonia_phage	1.3e-169	92.4
WP_014925948.1\|1561268_1561694_+	hypothetical protein	A0A1B3AZY5	Gordonia_phage	3.1e-49	83.3
WP_044506241.1\|1561693_1562083_+	hypothetical protein	A0A159B6C7	Gordonia_phage	1.2e-60	92.2
WP_044506243.1\|1562079_1562469_+	hypothetical protein	A0A162E127	Gordonia_phage	2.2e-54	89.1
WP_014925949.1\|1562461_1563265_+	cutinase family protein	A0A160DCV7	Gordonia_phage	6.2e-136	88.8
WP_014925950.1\|1563272_1563836_+	hypothetical protein	A0A2D1GGL3	Gordonia_phage	1.3e-07	39.2
WP_014925951.1\|1563838_1565038_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_158409748.1\|1565118_1566027_-	hypothetical protein	A0A2P1N2X3	Gordonia_phage	8.0e-31	34.2
WP_158409749.1\|1566181_1566913_+	hypothetical protein	NA	NA	NA	NA
WP_014925953.1\|1567000_1567534_+	hypothetical protein	NA	NA	NA	NA
WP_014925954.1\|1567684_1568074_-	hypothetical protein	NA	NA	NA	NA
WP_044506250.1\|1568116_1568344_-	hypothetical protein	A0A2P1A0S6	Gordonia_phage	2.9e-30	85.3
WP_049942583.1\|1568524_1568953_-	hypothetical protein	A0A1B3AZ71	Gordonia_phage	1.4e-65	86.6
1570506:1570547	attR	NA	NA	NA	NA

DBSCAN-SWA_2

3816726 : 3825785

Gordonia_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014927547.1\|3816726_3819729_+	DEAD/DEAH box helicase	A0A160DDV1	Gordonia_phage	7.2e-36	27.6
WP_014927548.1\|3819725_3820535_+	hypothetical protein	NA	NA	NA	NA
WP_010841379.1\|3820584_3821589_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A160DHK0	Gordonia_phage	2.2e-154	85.6
WP_014927549.1\|3821656_3823849_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	3.0e-209	51.5
WP_010841381.1\|3823934_3824450_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	Q4Z9B0	Staphylococcus_phage	1.8e-11	31.1
WP_004019249.1\|3824598_3824832_-	redoxin NrdH	V5UN81	Mycobacterium_phage	1.3e-22	66.2
WP_010841382.1\|3825227_3825785_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	1.2e-08	29.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_018583

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_018580

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NC_018581

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection