CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	4 crisprs	csa3,WYL,DinG,cas2,cas1,cas4,csm6,csx1,cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7,cas7,cas8c,cas5,cas3,cas8a8,cas6	0	34	3	1
NC_014212	Meiothermus silvanus DSM 9946, complete sequence	6 crisprs	Cas14u_CAS-V,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,cas6,csx1,cas1,cas2,c2c9_V-U4,cas3,cas8e,cse2gr11,cas7,cas5,cas6e,DEDDh,csa3,WYL	5	9	8	0
NC_014214	Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence	1 crisprs	Cas14u_CAS-V,c2c10_CAS-V-U3,cas14k,csx16,c2c4_V-U1	0	7	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014212_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014212_1

698282-699146

TypeIII

III-A

Consensus_repeat	Method
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	PILER-CR
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CRISPRCasFinder
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CRT

11 spacers

cas2,cas1,csx1,cas6,csm5gr7,csm4gr5,csm3gr7,csm2gr11

The CRISPR arrays of NC_014212_1

>merge|NC_014212|1|698282-699146|PILER-CR,CRISPRCasFinder,CRT
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAACCCGCTTCGGCCAGGGCCAGGGCCGCCCCCGCGCCCATCACCAGTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAACCAACCTGGATCGAGGAGCAGATCCAGCAACGAAATCCTGAAGGTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAACCGGCGGCCTCGAACTCGCCGTCGATGAAGAGCTCCGCAGTAAGTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAACAAGTTCCTCCTTACGCATCAGCTGCAAAAAAAGCTGAGTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAACGTCGTTGTAACCATCGATGAATGTGACACTTACAGTGTAGGGTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAACTTTACGGACTCAGAAGTGAAGTCAAGGAAGTATATACCTGTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAACAAGGACTTGCTGAAGCGCCTTATGCCTAGTTACTAAGGTGTGTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAACTTTCGTCATACTGTCATCTCCTTACCCTCGATTGTCGGGTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAACGCTCGGCGCAGGCGAGAATTATCTTTTCGTCGAAGTTTAGCGTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAACCCGTACGCACAGTACTCGGCTATGCCGACGCCGAGCTCACAGGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACGCAAAGAAGGACGGAAGGGTTAGTCGAGGGCTACGAACCGGTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC

>NC_014212|1|1|698282-699146|PILER-CR
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CCGCTTCGGCCAGGGCCAGGGCCGCCCCCGCGCCCATCACCA
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CAACCTGGATCGAGGAGCAGATCCAGCAACGAAATCCTGAAG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CGGCGGCCTCGAACTCGCCGTCGATGAAGAGCTCCGCAGTAA
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	AAGTTCCTCCTTACGCATCAGCTGCAAAAAAAGCTGA
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	GTCGTTGTAACCATCGATGAATGTGACACTTACAGTGTAGG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	TTTACGGACTCAGAAGTGAAGTCAAGGAAGTATATACCT
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	AAGGACTTGCTGAAGCGCCTTATGCCTAGTTACTAAGGTGT
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	TTTCGTCATACTGTCATCTCCTTACCCTCGATTGTCGG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	GCTCGGCGCAGGCGAGAATTATCTTTTCGTCGAAGTTTAGC
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CCGTACGCACAGTACTCGGCTATGCCGACGCCGAGCTCACAG
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	GCAAAGAAGGACGGAAGGGTTAGTCGAGGGCTACGAACCG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC

>NC_014212|1|1|698282-699146|CRISPRCasFinder
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CCGCTTCGGCCAGGGCCAGGGCCGCCCCCGCGCCCATCACCA
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CAACCTGGATCGAGGAGCAGATCCAGCAACGAAATCCTGAAG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CGGCGGCCTCGAACTCGCCGTCGATGAAGAGCTCCGCAGTAA
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	AAGTTCCTCCTTACGCATCAGCTGCAAAAAAAGCTGA
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	GTCGTTGTAACCATCGATGAATGTGACACTTACAGTGTAGG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	TTTACGGACTCAGAAGTGAAGTCAAGGAAGTATATACCT
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	AAGGACTTGCTGAAGCGCCTTATGCCTAGTTACTAAGGTGT
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	TTTCGTCATACTGTCATCTCCTTACCCTCGATTGTCGG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	GCTCGGCGCAGGCGAGAATTATCTTTTCGTCGAAGTTTAGC
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CCGTACGCACAGTACTCGGCTATGCCGACGCCGAGCTCACAG
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	GCAAAGAAGGACGGAAGGGTTAGTCGAGGGCTACGAACCG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC

>NC_014212|1|1|698282-699146|CRT
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CCGCTTCGGCCAGGGCCAGGGCCGCCCCCGCGCCCATCACCA
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CAACCTGGATCGAGGAGCAGATCCAGCAACGAAATCCTGAAG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CGGCGGCCTCGAACTCGCCGTCGATGAAGAGCTCCGCAGTAA
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	AAGTTCCTCCTTACGCATCAGCTGCAAAAAAAGCTGA
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	GTCGTTGTAACCATCGATGAATGTGACACTTACAGTGTAGG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	TTTACGGACTCAGAAGTGAAGTCAAGGAAGTATATACCT
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	AAGGACTTGCTGAAGCGCCTTATGCCTAGTTACTAAGGTGT
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	TTTCGTCATACTGTCATCTCCTTACCCTCGATTGTCGG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	GCTCGGCGCAGGCGAGAATTATCTTTTCGTCGAAGTTTAGC
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC	CCGTACGCACAGTACTCGGCTATGCCGACGCCGAGCTCACAG
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	GCAAAGAAGGACGGAAGGGTTAGTCGAGGGCTACGAACCG
GTCGCAAACAAAAAGCCCCGTAAGGGGATTGCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014212.1\|WP_013157211.1\|695289_696690_+\|TIGR02710-family-CRISPR-associated-protein	csx1	cd09747_csx1_CAS-III	gnl\|CDD\|378236
NC_014212.1\|WP_049777780.1\|707131_708079_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350122
NC_014212.1\|WP_013157221.1\|706222_706966_-\|basic-amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270342
NC_014212.1\|WP_013157209.1\|694209_694551_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350219
NC_014212.1\|WP_013157218.1\|703953_704901_-\|agmatinase	unknown	unknown	gnl\|CDD\|212538
NC_014212.1\|WP_013157212.1\|696686_697658_+\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NC_014212.1\|WP_013157208.1\|693955_694210_+\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl\|CDD\|377904
NC_014212.1\|WP_013157216.1\|702083_703211_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_014212.1\|WP_013157219.1\|704911_705475_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380339
NC_014212.1\|WP_013157210.1\|694547_695351_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|273848
NC_014212.1\|WP_013157213.1\|697659_697935_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0081_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NC_014212.1\|WP_013157223.1\|708242_710549_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|226418
NC_014212.1\|WP_013157215.1\|700683_701763_+\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_014212.1\|WP_013157206.1\|691910_692798_+\|CRISPR-associated-protein-Csm4	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	gnl\|CDD\|273866
NC_014212.1\|WP_013157220.1\|705477_706128_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_014212.1\|WP_013157214.1\|699166_700375_+\|TIGR02710-family-CRISPR-associated-protein	csx1	cd09702_csx1_CAS-III	gnl\|CDD\|274263
NC_014212.1\|WP_013157204.1\|690829_691240_+\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	gnl\|CDD\|187778
NC_014212.1\|WP_013157217.1\|703219_703957_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_014212.1\|WP_013157207.1\|692794_693925_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl\|CDD\|273863
NC_014212.1\|WP_013157205.1\|691236_691914_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815

Protein	Function_ID	Function_description	E-value
NC_014212.1\|WP_013157211.1\|695289_696690_+\|TIGR02710-family-CRISPR-associated-protein	gnl\|CDD\|378236	pfam09670, Cas_Cas02710, CRISPR-associated protein (Cas_Cas02710). Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).	6.12176e-66
NC_014212.1\|WP_049777780.1\|707131_708079_-\|hypothetical-protein	gnl\|CDD\|350122	cd18610, GH130_BT3780-like, Glycosyl hydrolase family 130, such as beta-mammosidase BT3780 and BACOVA_03624. This subfamily contains glycosyl hydrolase family 130, as classified by the carbohydrate-active enzymes database (CAZY), and includes Bacteroides enzymes, BT3780 and BACOVA_03624. Members of this family possess 5-bladed beta-propeller domains similar to families 32, 43, 62, 68, 117 (GH32, GH43, GH62, GH68, GH117). GH130 enzymes are involved in the bacterial utilization of mannans or N-linked glycans. GH130 enzymes have also been shown to target beta-1,2- and beta-1,4-mannosidic linkages where these phosphorylases mediate bond cleavage by a single displacement reaction in which phosphate functions as the catalytic nucleophile. However, some lack the conserved basic residues that bind the phosphate nucleophile, as observed for the Bacteroides enzymes, BT3780 and BACOVA_03624, which are indeed beta-mannosidases that hydrolyze beta-1,2-mannosidic linkages through an inverting mechanism.	4.67995e-133
NC_014212.1\|WP_013157221.1\|706222_706966_-\|basic-amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270342	cd13624, PBP2_Arg_Lys_His, Substrate binding domain of the arginine-, lysine-, histidine-binding protein ArtJ; the type 2 periplasmic binding protein fold. This group includes the periplasmic substrate-binding protein ArtJ of the ATP-binding cassette (ABC) transport system from the thermophilic bacterium Geobacillus stearothermophilus, which is specific for arginine, lysine, and histidine. ArtJ belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.25116e-90
NC_014212.1\|WP_013157209.1\|694209_694551_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350219	cd09871, PIN_MtVapC28-VapC30-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC28 and 30 and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC28 and VapC30 toxins. M. tuberculosis VapC28 and VapC30 both cleave tRNA25Ser-TGA and tRNA28Ser-CGA. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	3.82608e-40
NC_014212.1\|WP_013157218.1\|703953_704901_-\|agmatinase	gnl\|CDD\|212538	cd11592, Agmatinase_PAH, Agmatinase-like family includes proclavaminic acid amidinohydrolase. This agmatinase subfamily contains bacterial and fungal/metazoan enzymes, including proclavaminic acid amidinohydrolase (PAH, EC 3.5.3.22) and Pseudomonas aeruginosa guanidinobutyrase (GbuA) and guanidinopropionase (GpuA). PAH hydrolyzes amidinoproclavaminate to yield proclavaminate and urea in clavulanic acid biosynthesis. Clavulanic acid is an effective inhibitor of beta-lactamases and is used in combination with amoxicillin to prevent the beta-lactam rings of the antibiotic from hydrolysis and, thus keeping the antibiotic biologically active. GbuA hydrolyzes 4-guanidinobutyrate (4-GB) into 4-aminobutyrate and urea while GpuA hydrolyzes 3-guanidinopropionate (3-GP) into beta-alanine and urea. Mutation studies show that significant variations in two active site loops in these two enzymes may be important for substrate specificity. This subfamily belongs to the ureohydrolase superfamily, which includes arginase, agmatinase, proclavaminate amidinohydrolase, and formiminoglutamase.	2.31704e-170
NC_014212.1\|WP_013157212.1\|696686_697658_+\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.67275e-88
NC_014212.1\|WP_013157208.1\|693955_694210_+\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl\|CDD\|377904	pfam07704, PSK_trans_fac, Rv0623-like transcription factor. This entry represents the Rv0623-like family of transcription factors associated with the PSK operon.	1.91388e-11
NC_014212.1\|WP_013157216.1\|702083_703211_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	1.91756e-108
NC_014212.1\|WP_013157219.1\|704911_705475_-\|cupin-domain-containing-protein	gnl\|CDD\|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	7.96944e-23
NC_014212.1\|WP_013157210.1\|694547_695351_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.83894e-18
NC_014212.1\|WP_013157213.1\|697659_697935_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.45858e-27
NC_014212.1\|WP_013157223.1\|708242_710549_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	2.33416e-49
NC_014212.1\|WP_013157215.1\|700683_701763_+\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	8.75597e-18
NC_014212.1\|WP_013157206.1\|691910_692798_+\|CRISPR-associated-protein-Csm4	gnl\|CDD\|273866	TIGR01903, Hypothetical_protein., CRISPR type III-A/MTUBE-associated RAMP protein Csm4. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. Members of this cas gene family are found in the mtube subtype of CRISPR/cas locus and designated Csm4, for CRISPR/cas Subtype Mtube, protein 4.	1.04234e-19
NC_014212.1\|WP_013157220.1\|705477_706128_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	5.93306e-87
NC_014212.1\|WP_013157214.1\|699166_700375_+\|TIGR02710-family-CRISPR-associated-protein	gnl\|CDD\|274263	TIGR02710, conserved_hypothetical_protein, CRISPR-associated protein, TIGR02710 family. Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Archaea), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).	2.07053e-94
NC_014212.1\|WP_013157204.1\|690829_691240_+\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|187778	cd09647, Csm2_III-A, CRISPR/Cas system-associated protein Csm2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; signature gene for subtype III-A.	1.21085e-14
NC_014212.1\|WP_013157217.1\|703219_703957_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.99273e-158
NC_014212.1\|WP_013157207.1\|692794_693925_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|273863	TIGR01899, cas_TM1807_csm5, CRISPR type III-A/MTUBE-associated RAMP protein Csm5. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. Members of this cas gene family are found in the mtube subtype of CRISPR/cas locus and designated Csm5, for CRISPR/cas Subtype Mtube, protein 5.	1.89209e-15
NC_014212.1\|WP_013157205.1\|691236_691914_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	8.36469e-86

>NC_014212.1|WP_013157213.1|697659_697935_+|CRISPR-associated-endonuclease-Cas2
MPTERFYTVTYDIPDDGRRVKVANTLKSFGERVQLSVFECWLNPAQLEQLKKLLQKKLKPTEDGVRIYPVGGTVEVLGVGRIADNPDYLIL
>NC_014212.1|WP_013157212.1|696686_697658_+|CRISPR-associated-endonuclease-Cas1
MTLHLTEQSSTLRLRAGRLLVELDEQILAELPARKVRGVVVWGNVRLTTPALAFLLRQGVPVLYATLEGQLYGQAQAPQSLAPQVLRAQMQAQQDPLPLAQSFLQGKLRSELILLERLSRQAPTALQQAEIRAALSDLPQTRGLEALRGVEGSAARAYFAGLQAVLSPYGFAGRNRRPPTDAVNAALSYGYMVLLGRTLLALHLAGLHPELGLLHAEGRRAPALAFDLMEEFRVAVVDVIVTAAFLRGELDLQKHAEARDGGVYLNDTGRKVLLKLLEGRLAQEAQHPKGFRKPYQELIEAQAARLKAAILGREAYTPFYLWR
>NC_014212.1|WP_013157211.1|695289_696690_+|TIGR02710-family-CRISPR-associated-protein
MEDLMQKIHLAWQHLKTQELEGARAQELYNQTVWPLLLELWRLEPQVHPLRESFDVSIHTLGTSPEATTLAALGLGADEIYVLHTPESRRYLAQLQQDLGRPVYPIEIDKSDVTRLYQVVGEQVRKHPGKKIALDLTSGTKAMSAGMAAAGYFLQRVHPSLRVAYVDNDAFDVALRKPVAGTEKLILLPNPHEVLGDLDEHLAQEFYKAREFGKAADRYNELRRKTGQGGFEVYAALCEMYQRWYALDFEGALSNAERLLKFLSQDAYRNHPLNLRAQRIKEQKEGLEGIVSLLKSQSFAEKKDILWLTATLLQLGDERKERQPVLAALYFYRALELILQHRIAVNGRSNDNPVLTPEEQDHLRQSLARWLKRSLEEIKPITKLGLLESMALLRYLEDPLLDNFSENDLQGYQGMLQSRNKSLLIHGLEVSKKGDVEKLQQFARKLYLTTREEAKLALSVEPVELM
>NC_014212.1|WP_013157210.1|694547_695351_+|CRISPR-associated-endoribonuclease-Cas6
MMLAALVLPLEGQARPDPDGWRGLVYGLLKEIDPELHTAQHNPFSLGLGGAEGQWWVRIALLEEGLYARLSPHLFGLVGQSVKLKEPFRVRAVLQEEHPWASLSTYPRLFQGQASPSLGLQFASPTFFRRKGNSYPLPEPKLVFDSLTQRWNAFAPVKVPPEMAETWERVTITRLQGHTQAIRPNPDERGVGFVGRVVYHLPAAKPTEAQWMQALGRFAFYAGVGAKTSLGFGRVRGFDPILKEESANGRLDAEDSSSLATPQDPGA
>NC_014212.1|WP_013157209.1|694209_694551_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MVLGSSVLLHILFREPGYPEVARKLNGASQLLVGAPTLVETAMVLIHREGDTQLLVLEDFLRRLRVESAFRRFGKGRHPAALNLGDCLSYAVAKVSGLPLAYVGDDFAHTDLA
>NC_014212.1|WP_013157208.1|693955_694210_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MALTVKNLEVECLAEEVACLAGETKTEAIRKALLERKARLARPERPRSEVIEEFLRDMQDLLPKGRRPTKGEEEEILGFGPEGY
>NC_014212.1|WP_013157207.1|692794_693925_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MSFLESYRLELETLGPIHVGTGEAFPAYSYLVDEAQKEALILDAGRLLELLSETQRENYLQAVAQGPKQAQKSLQSLWGGGLLDPTPAIVRRLPATPAFINTVKNATDAAGLEFRPLPRSPLGAYLPGSSLKGALRTAWLFKRVVQQGRDIEYKGRWQWGQKVQGGEWPLIQLPERISTPVAQAFEALVLDYVTERSPNLHRDPFRQVRVSDSEPSENLLLNRIGVFHPRGQMDQTVILAEMFRVGTKLQATLRLHVGLAQQRHKDTVSHAISAQALAEACREYYLEVLHLEREYAQNHGLAQALKVYDAMAQRLEAEEYLFPLRIGFGSGRMSIRLALLLDGEEGQEPKTRKTAGHSSPKDGFPLGWAIARLEPY
>NC_014212.1|WP_013157206.1|691910_692798_+|CRISPR-associated-protein-Csm4
MRVKAFHLALGSISAPPSAPTLWGHLAWWVRYTQGERALLEWLEAFRHDPPFLISSAFPTGYLPRPLLPQVRIDDTAKRKSLKSIRYLSFATFARVIREGEQALLESPELKEKKAPKVTLATQTRVGINRTTGTAQEGILFTDRVYWLGDQEKKQTWTVYVQIRQPADYLEQALREIGTFGYGGKASVGLGRFEVVDTQEMDLPEAPSPTHYVTLSPTLPKGEGYWALETYWGRLGGHYAQAETPFKRPYLRAKEGSVFREQPTAGLLDVTPEPAPEGGVKIWEYLYAFPLGVRV
>NC_014212.1|WP_013157205.1|691236_691914_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MRLIGYKRIHGIIRLKSGLRIGMSKDQMAIGDVDNPVIRNPLTEEPYIPGSSLKGKMRYLLEWHLGGDYISRSSERHVYVPDDPKDPVGRIFGSAPSNEAQRRIAQERGPTRLLVRDAYLTPNSKQALERMTARGGYLTEVKQEVFIPRIGGNANPRTAERVPAGAEFAFEMVYRVMDTGDGGQTDRANFHHVEKALELLQLDGLGGYISRGYGQVELDYRVEEK
>NC_014212.1|WP_013157204.1|690829_691240_+|type-III-A-CRISPR-associated-protein-Csm2
MEFYQDRQNKILRPGLFDTDARKDADGVQGIQSSQFRNYFHELRTLEANYEREAKANSKLAFAKLVPQLELLKAKLAYGQRKNGPLQNAGGFVSLMNRLIDAGKKSPEDFEAMMQYLEAVLAYFYAKEGQNQGGRR
>NC_014212.1|WP_013157214.1|699166_700375_+|TIGR02710-family-CRISPR-associated-protein
MQEIKQVLIATVGHSRAPVEFALAEHAPEGVVFIASQDSQLVAAELMREYGAHLRHHTFLLDDPESLTESYLVAQKALRKALEWEARSVVADVTGGTKPMVAGVVLALSGRGVTFSYVGGEQRDEVGRVVGGAERLKLLEDPTTRYGVREWAEFVQAWNIGQMDAAKSHLEALLQRDLSPSERRFYQHLKGVVEGLTAWDRFQHAAAQKLLREHLEPALAVAEAWGHGSKVRVLQALKVATQGLQKLLEQGNVPSFELVADLLANAQRRAAAGRYDDALARLYRAVELAAEADVYARHKLVLRRPETYPEAVATLKDRAVGLRGLKETLALAFDLDVRAGYTGTLAQRLYGDYAQRLQGLLDRRHQSILAHGTKPVAVEDYQALWDYLVECGLEAAPTWPKW
>NC_014212.1|WP_013157215.1|700683_701763_+|transposase
MQFTTVGREIWRGARQAQRLAEANASDPEVQERLRKLRLVKALRESKKSWKEIQDLVGISRATYHRWQKALKEKGLAGLKPRSRRPKHLRTKVHWTPGLLIRIETLRKENPTWGRWSIWLTLRKEGFQMSERTVGRILAYLEKHRRIESVAGYLARTQRGKLKRRVNRPYAKRKPRGYEARAPGDLVQVDTLTLTLGPGSMVKHFSAIDLHSRFVLAEVHSRATAKLSEGFLSLLLARAPFPIRAIQVDGGSEFMAEFEEACCALGIALFVLPPRSPKLNGHVERMQRTFKEEFYTRPLPTPLSELQAELDTYLDYYNRRRPHMALGGLAPLEFLAKMQEESVPQRVSNVLTDYRCLTG
>NC_014212.1|WP_013157216.1|702083_703211_-|PLP-dependent-aminotransferase-family-protein
MLDVTQTRIPQGVIDLGVGHPSLGLLPLEELRQAALHRLSQGNPAFLQYGAEPGDGYFRTELAGFLSRHYGFSLEPDTLFVTAGVSQALDLICTAFTRPGQVIFVEEPTYFLSLGIFRDHHLEVVALPTDADGLDITALEAALRQHQPALVYTIPTFQNPTGATLSQQRRKRLVELSQEYGFLIVADEVYQLLYYHQSPPLSLGSFAAAGTVLSLGSFSKILAPGLRLGWIQAAPRLLHTLTRNGMVASGGGLNPFASAIVRSALELGLQEQHLHKLRNTYRGRLETLLEALRQNGLRPRYTPEGGYFVWLELDPAADSQVLLEQAIQAGVRYQPGVRFSSQGNFAHALRLCFAYYDSAELKKGIQRLAAVLRSS
>NC_014212.1|WP_013157217.1|703219_703957_-|amino-acid-ABC-transporter-ATP-binding-protein
MSGAIIQIQGLNKWFGRLHVLREVNLEVAAGEKVVIVGPSGSGKSTLIRCINRLEDFQQGEVFVDGIPLRSAQNLEAVRREVGMVFQQFNLFPHMTVLQNAALAPQKVRRWPKEQAERKAMELLERVGIADQAHKYPGQLSGGQQQRVAIARALAMEPKIMLFDEPTSALDPEMVGEVLDVMRDLAESGMTMLVVTHEMAFAKEVADRVIVMDQGQILEQAPPSVIFQNPTHERTRTFLQRVLHH
>NC_014212.1|WP_013157218.1|703953_704901_-|agmatinase
MKYQPAHSLESPRFAGVRTFMRLPHVRTLENVDFVVLGIPWDDATTHRPGARFGPEGIRRVSIMLRPWNPYWNVKIFDYLSGVDYGDVPVVPGYIEDTYARIESEFEKIARSGVTPIAMGGDHSVTLGELRGLAKVYGPLALVHIDAHLDTLDQYFGRKYNHGTPFRRAVEEGLVDPHKSIQVGIRGSNYGPEDYQGTRDLGYELITMYELQEIGLEAALERIHRRVGQHPCFISIDIDSVDPAYAPGTGTPEVEGFTSREIMKLVRGLRGLHFKAADVVEVLPALDPGEITAYLGGNLIYELISLLALRKKEGG
>NC_014212.1|WP_013157219.1|704911_705475_-|cupin-domain-containing-protein
MARASSPPPSFPIGQRLRATRLAKGFTLEQVAKRSGLDKSFISRLERDATAASVASLLKVCGALGIQPGSLFDPPKTNLVRAEEAPSANFGGQGVQDFILSRGLRGEIMVLRTEIEPGGHGGKELYIFPADTDFVTVLEGSLEFTVGEARYTLHPGDSLTFCGQEPHTWRNLGKSRAVVLWVLSPAP
>NC_014212.1|WP_013157220.1|705477_706128_-|amino-acid-ABC-transporter-permease
MDFGLIRDSLPFLLQGAWVTLRITALSLIFGVFLGTLVALARMSPIRWLSGLTLGYIELLRGTPLLVQIFLIFFGIPQLTQQQINEFVAGVIAFSINSSAYVAEILRAGIQSIPKGQREAALSLGFSPTQTLRYIILPQAFIRVIPPLVNEGIALLKNSSLLSAIAVVELTRAGQLISARTFKPFEMYLAVSLIYLVMTVILSFVARQLEARWQVR
>NC_014212.1|WP_013157221.1|706222_706966_-|basic-amino-acid-ABC-transporter-substrate-binding-protein
MRKWFAVLALVGLLGASSTLAQSCLASAKANGLTVGTSPDYPPFESLDKDNKIIGFDVDLINAIAGELGLKVSVIGQSFDGLIPALLSKKIDVIAAGLTITEERKKSVDFTRPYISGPNVIITRKETSGISKLEDLAGKKVAVQIGSAQEKIASGVKGAQVKSYNLYTDAALAVNTRQADALIVHRFVGRAFLKQYPDLKIVAELNQVDTGLALRKDCGDLRQAIDAAIEKLEQNGKMDELAAKWFK
>NC_014212.1|WP_049777780.1|707131_708079_-|hypothetical-protein
MRILPLILLALLGGTAENVSSSLPGPFTRALENPLLTPQGQGWEALAVFNPAVIYADGHYWMLYRAQDPQGISRLGLATSSDGLHFVRESQPVLSPSDPGEAGGVEDPRLVRIGGRYYLTYTGYDGRRVAQTRLAVSEDLREWRKLGVIIDTPWNKAGAILDQPLDGLYFMYFGDREIQLATSRDLRRWRVEPEAVLKPRPGMWDEGGVEPGPPPLLTPKGILLIYNGRDHRNVYAVGAALFSAGDPSQLLARSETPLLQAEAPYEREGTVPNVVFAEGLVVREGVWRLYYGGGDRVVGLATAKLAELLEFAKSG
>NC_014212.1|WP_013157223.1|708242_710549_+|tetratricopeptide-repeat-protein
MDVGWWDSDGSVYTGGLYRLPLQPYPLIGRQRDLNAAEALLLRGDVRLFTVVGPPGVGKTRFALELASRVAPRFSEGVAFVDLAPVREAGLVLDAVARVLGVAEHPDRTMLAQLQRHLGNQSLLLILDNLEHVIAAAADLAGLLEASPQVKLLVTSRQPLHLRWEHRYNLLPLTLPDAAAGLEDALLRYPATALFLERARMADAAFSVDAGRTLAVVEICRRLDGLPLAIELAAAWTAVLGPEAVLSRLLAHRVFPLGSSRDGPERQRTLFDAIAWSYDLLNEAERRVFRALGAFAGETPLEAIEAVCEGLGVDVLTPVAGLVDKNLLLRVGEGETRFRMLETIRSFAEEQLERMGEATVVRHRHAAWFLGLARRAERFIWSEHQAVWLLRLERAHDNVRLALNWCFSGGDEETGVLLVAAMHRFWFARGYIREGRKWNELAASKRQVSDRGRALALRNLAFFLTQQGEAEQALGLAEQAAALARSVGEPSLLAWILHGLALVTDAVGDIERSERLNREILDRARQAGDEALAIRALGGIGSVLHRRGDISQARTFFEEALALARPRHDKWLMSVVTRNLGLALASEDPAQALALLQESLALAYEIGHRSLTVRGLEALAGLQAQAEAAAKLLGASEVFRDAFGLKRGSSSEAWVAAVRERLGPAAFEAAWNQGQAMTPGEAVALALGRGAPLPIAQVQRPGGLTDREIQVVWEIASGLTNRQIAEKLEISQRTVDAHVQNILNKLGVEKRTQIAVWASRHLKEDPSP

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Crispr_ID: NC_014212_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014212_2

1221053-1221692

TypeI-E

I-E

Consensus_repeat	Method
GTATTCCCCGCACACGCGGGGATGAACCG	PILER-CR
GTATTCCCCGCACACGCGGGGATGAACCG	CRISPRCasFinder
GTATTCCCCGCACACGCGGGGATGAACCG	CRT

10 spacers

cas2,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,cas3

The CRISPR arrays of NC_014212_2

>merge|NC_014212|2|1221053-1221692|PILER-CR,CRISPRCasFinder,CRT
GTATTCCCCGCACACGCGGGGATGAACCGATCAAACGCTCCTCGGCGAGGCTCAGGCGCAGGTATTCCCCGCACACGCGGGGATGAACCGGAGATGGAATGACCAAGGAAAATATACCACAAGTATTCCCCGCACACGCGGGGATGAACCGTCTCTCCAGATCTTCGGCGCTTCCCACGCCAGTATTCCCCGCACACGCGGGGATGAACCGTACCACACCCCCCTCAGCCTGAACCGGTAGACGTATTCCCCGCACACGCGGGGATGAACCGCAAGCACGGAAGGCGAAGAATATATCTCGCCGCGTATTCCCCGCACACGCGGGGATGAACCGCTGGTGGCGCGACTGGGGGGGTGACAAAACTAGTATTCCCCGCACACGCGGGGATGAACCGCGGCTAGGGGGGGTAACGGTGTTCTCCCAGGCGTATTCCCCGCACACGCGGGGATGAACCGAGCGTGGCAAAATTGACGTGCGGCGCTCTAAAGTATTCCCCGCACACGCGGGGATGAACCGGAGGTCGCATATGGGAATCTTTAGAGGAATCAAGTATTCCCCGCACACGCGGGGATGAACCGAAATTCATTAGCAGTAGAACTTAATCCTGAACGTATTCCCCGCACACGCGGGGATGAACCG

>NC_014212|2|2|1221053-1221692|PILER-CR
GTATTCCCCGCACACGCGGGGATGAACCG	ATCAAACGCTCCTCGGCGAGGCTCAGGCGCAG
GTATTCCCCGCACACGCGGGGATGAACCG	GAGATGGAATGACCAAGGAAAATATACCACAA
GTATTCCCCGCACACGCGGGGATGAACCG	TCTCTCCAGATCTTCGGCGCTTCCCACGCCA
GTATTCCCCGCACACGCGGGGATGAACCG	TACCACACCCCCCTCAGCCTGAACCGGTAGAC
GTATTCCCCGCACACGCGGGGATGAACCG	CAAGCACGGAAGGCGAAGAATATATCTCGCCGC
GTATTCCCCGCACACGCGGGGATGAACCG	CTGGTGGCGCGACTGGGGGGGTGACAAAACTA
GTATTCCCCGCACACGCGGGGATGAACCG	CGGCTAGGGGGGGTAACGGTGTTCTCCCAGGC
GTATTCCCCGCACACGCGGGGATGAACCG	AGCGTGGCAAAATTGACGTGCGGCGCTCTAAA
GTATTCCCCGCACACGCGGGGATGAACCG	GAGGTCGCATATGGGAATCTTTAGAGGAATCAA
GTATTCCCCGCACACGCGGGGATGAACCG	AAATTCATTAGCAGTAGAACTTAATCCTGAAC
GTATTCCCCGCACACGCGGGGATGAACCG

>NC_014212|2|2|1221053-1221692|CRISPRCasFinder
GTATTCCCCGCACACGCGGGGATGAACCG	ATCAAACGCTCCTCGGCGAGGCTCAGGCGCAG
GTATTCCCCGCACACGCGGGGATGAACCG	GAGATGGAATGACCAAGGAAAATATACCACAA
GTATTCCCCGCACACGCGGGGATGAACCG	TCTCTCCAGATCTTCGGCGCTTCCCACGCCA
GTATTCCCCGCACACGCGGGGATGAACCG	TACCACACCCCCCTCAGCCTGAACCGGTAGAC
GTATTCCCCGCACACGCGGGGATGAACCG	CAAGCACGGAAGGCGAAGAATATATCTCGCCGC
GTATTCCCCGCACACGCGGGGATGAACCG	CTGGTGGCGCGACTGGGGGGGTGACAAAACTA
GTATTCCCCGCACACGCGGGGATGAACCG	CGGCTAGGGGGGGTAACGGTGTTCTCCCAGGC
GTATTCCCCGCACACGCGGGGATGAACCG	AGCGTGGCAAAATTGACGTGCGGCGCTCTAAA
GTATTCCCCGCACACGCGGGGATGAACCG	GAGGTCGCATATGGGAATCTTTAGAGGAATCAA
GTATTCCCCGCACACGCGGGGATGAACCG	AAATTCATTAGCAGTAGAACTTAATCCTGAAC
GTATTCCCCGCACACGCGGGGATGAACCG

>NC_014212|2|2|1221053-1221692|CRT
GTATTCCCCGCACACGCGGGGATGAACCG	ATCAAACGCTCCTCGGCGAGGCTCAGGCGCAG
GTATTCCCCGCACACGCGGGGATGAACCG	GAGATGGAATGACCAAGGAAAATATACCACAA
GTATTCCCCGCACACGCGGGGATGAACCG	TCTCTCCAGATCTTCGGCGCTTCCCACGCCA
GTATTCCCCGCACACGCGGGGATGAACCG	TACCACACCCCCCTCAGCCTGAACCGGTAGAC
GTATTCCCCGCACACGCGGGGATGAACCG	CAAGCACGGAAGGCGAAGAATATATCTCGCCGC
GTATTCCCCGCACACGCGGGGATGAACCG	CTGGTGGCGCGACTGGGGGGGTGACAAAACTA
GTATTCCCCGCACACGCGGGGATGAACCG	CGGCTAGGGGGGGTAACGGTGTTCTCCCAGGC
GTATTCCCCGCACACGCGGGGATGAACCG	AGCGTGGCAAAATTGACGTGCGGCGCTCTAAA
GTATTCCCCGCACACGCGGGGATGAACCG	GAGGTCGCATATGGGAATCTTTAGAGGAATCAA
GTATTCCCCGCACACGCGGGGATGAACCG	AAATTCATTAGCAGTAGAACTTAATCCTGAAC
GTATTCCCCGCACACGCGGGGATGAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014212.1\|WP_013157710.1\|1223882_1224503_-\|phosphoribosylanthranilate-isomerase	unknown	unknown	gnl\|CDD\|238237
NC_014212.1\|WP_169307849.1\|1214181_1214358_+\|hypothetical-protein	unknown	unknown	unknown
NC_014212.1\|WP_013157713.1\|1227347_1228853_+\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NC_014212.1\|WP_041653160.1\|1219717_1220701_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_014212.1\|WP_013157715.1\|1229715_1230399_+\|CHAD-domain-containing-protein	unknown	unknown	gnl\|CDD\|214880
NC_014212.1\|WP_174263499.1\|1225365_1227219_-\|polyphosphate-kinase	unknown	unknown	gnl\|CDD\|235469
NC_014212.1\|WP_013157232.1\|1222175_1223312_-\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_014212.1\|WP_013157708.1\|1220654_1221032_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	pfam09707_cas2_CAS-I-E	gnl\|CDD\|378244
NC_014212.1\|WP_013157717.1\|1230844_1231618_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NC_014212.1\|WP_041653157.1\|1211245_1213960_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
NC_014212.1\|WP_013157704.1\|1217217_1218384_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_014212.1\|WP_013157702.1\|1216080_1216680_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09731_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NC_014212.1\|WP_013157709.1\|1223445_1223817_+\|hypothetical-protein	unknown	unknown	unknown
NC_014212.1\|WP_013157711.1\|1224625_1225363_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|132997
NC_014212.1\|WP_013157701.1\|1214411_1216097_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|378189
NC_014212.1\|WP_013157716.1\|1230388_1230754_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319909
NC_014212.1\|WP_013157714.1\|1229207_1229693_+\|phosphohistidine-phosphatase-SixA	unknown	unknown	gnl\|CDD\|224973
NC_014212.1\|WP_013157706.1\|1219058_1219685_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09727_cas6e_CAS-I-E	gnl\|CDD\|378050
NC_014212.1\|WP_013157705.1\|1218385_1219084_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|273842
NC_014212.1\|WP_013157703.1\|1216676_1217207_+\|DUF2939-domain-containing-protein	unknown	unknown	gnl\|CDD\|378575

Protein	Function_ID	Function_description	E-value
NC_014212.1\|WP_013157710.1\|1223882_1224503_-\|phosphoribosylanthranilate-isomerase	gnl\|CDD\|238237	cd00405, PRAI, Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric, monofunctional and thermolabile, but in some thermophile organisms PRAI is dimeric for reasons of stability and in others it is fused to other components of the tryptophan biosynthesis pathway to form multifunctional enzymes.	1.01102e-71
NC_014212.1\|WP_013157713.1\|1227347_1228853_+\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	3.09625e-127
NC_014212.1\|WP_041653160.1\|1219717_1220701_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	2.43061e-141
NC_014212.1\|WP_013157715.1\|1229715_1230399_+\|CHAD-domain-containing-protein	gnl\|CDD\|214880	smart00880, CHAD, The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family. It has conserved histidines that may chelate metals.	6.42083e-17
NC_014212.1\|WP_174263499.1\|1225365_1227219_-\|polyphosphate-kinase	gnl\|CDD\|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NC_014212.1\|WP_013157232.1\|1222175_1223312_-\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	1.21976e-17
NC_014212.1\|WP_013157708.1\|1220654_1221032_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|378244	pfam09707, Cas_Cas2CT1978, CRISPR-associated protein (Cas_Cas2CT1978). This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteristic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.	2.06511e-43
NC_014212.1\|WP_013157717.1\|1230844_1231618_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	2.16674e-67
NC_014212.1\|WP_041653157.1\|1211245_1213960_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	8.25631e-119
NC_014212.1\|WP_013157704.1\|1217217_1218384_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	4.61789e-163
NC_014212.1\|WP_013157702.1\|1216080_1216680_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	1.48656e-29
NC_014212.1\|WP_013157711.1\|1224625_1225363_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|132997	cd00761, Glyco_tranf_GTA_type, Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.	3.48924e-22
NC_014212.1\|WP_013157701.1\|1214411_1216097_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	1.23957e-116
NC_014212.1\|WP_013157716.1\|1230388_1230754_-\|glyoxalase	gnl\|CDD\|319909	cd07245, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.4622e-27
NC_014212.1\|WP_013157714.1\|1229207_1229693_+\|phosphohistidine-phosphatase-SixA	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	3.5994e-23
NC_014212.1\|WP_013157706.1\|1219058_1219685_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	1.77117e-69
NC_014212.1\|WP_013157705.1\|1218385_1219084_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	3.87523e-51
NC_014212.1\|WP_013157703.1\|1216676_1217207_+\|DUF2939-domain-containing-protein	gnl\|CDD\|378575	pfam11159, DUF2939, Protein of unknown function (DUF2939). This bacterial family of proteins has no known function.	1.49458e-29

>NC_014212.1|WP_013157708.1|1220654_1221032_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MVVIILEKVPKTLRGELSRWMLEVGTGVFVGSVSALVRDLLWEKCVAKKTAGRCCLLYRTNNEQGFAVRTHGDTTRTLVDFDGLTLVAVKNAEWERMHRKTKRKRPGENLDNQTRDCDTSGGSSG
>NC_014212.1|WP_041653160.1|1219717_1220701_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MPRKRGDGPYETRNLQELPKFRDGLSYIYLEHGRIEQQDQAVAYYSQEGVVSIPAAALGVLLLGPGTAITHAAIRQLANNGCSVFWVGEEMVRFYASGMGETRSSANLMRQAQAWANPEAHLEVVKRLYRMRFPEPLSPELSLEQIRGLEGVRVRDTYARWSRETGVEWKGRNYNRGNWAEADPINRALSAGAACLYGLAHAAIVSAGYSPALGFIHTGKQLSFVYDMADIYKAETLIPTAFRVVAESDVGVERRVRCTLRDQLREVRLLERIVSDLHSLFDALDVPDPYAADAASPGELWDPSGPVPGGIAYGSDHPGEGAQDPEG
>NC_014212.1|WP_013157706.1|1219058_1219685_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSRLLLDPRHKQARTDLANPYQMHATLCHAFAEPEQTPPRFLWRAEEGKTPTVLVQSIETPNWEKLTQRFPGYFSQRPESKPIPLEHLQSGQVLRFRLRANPTVTRKDPQNPQKSKRHGLKEVEEQLEWLSRQGRKGGFAVLGAMVAQSERVKMFKHTGGSPIVLQSVLYDGHLRITDLEAFKNTLTGGLGHAKALGFGLLSIARG
>NC_014212.1|WP_013157705.1|1218385_1219084_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MPTLLLRLAGPMQSWGTKSRFDERDTDLSPSKSGVIGLLCAAMGIDREKREPVLQLADLRMGVRLDQPGVLRYDYQTAQNVIAADASKVHPTTVSRRYYLADAVFLVGLEGEDRRLLECAHQALKNPVWPLFLGRKGYVPSPGVYLKDGLRDEPLQEALKNYRFLGRDWPEDEEGKDLESARLPVMLENRDSSEGSLRMDQPLGSFAERRFGARFVVPDFVEVKRVSEPTPA
>NC_014212.1|WP_013157704.1|1217217_1218384_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MKHLLEIHILQNFAPSNLNRDDTGSPKDAIFGGVRRGRISSQCLKRAAREYVRDHPGGLPQEALALRTKRLVQALVEQLKAKGRDEEEARQKVEQALGGMGLKVDAEGKTQYLLFLGKQEVARIADLIEQHWDGLVAPQAEEEGGKKKAREAKKAAKEAVPDEIKKALGSVLDGGKALDVALFGRMLADLPEKNQDAACQVAHAISTHAVEREFDFYTAVDDLKPDDNAGADMLGTVEFNSACFYRYAAIDLEKLRANLQGDAELMLKSLEAFLRAMVKAKPSGKQNSFAAHNDPEYVVFTVRQEADPRNLANAFEKPIRPNKEKSLTEASLEQLEAKWQKLSEAYDQNGEAWVLNLTEVKSQIGTPVKNLGELVAKALEKVRANMGV
>NC_014212.1|WP_013157703.1|1216676_1217207_+|DUF2939-domain-containing-protein
MNTESQEKSTPTPKKPLLFLAVLAGLLLLLAYAWFSPYLTLRGIQQSIQRNNPSALERYIDFPRVRESLRADLNRMLVEQASQDQTGFGALGLLFVAPLIDQLVSVLVTPEGLASIGTGQEPQKGDLGAVRDWRLKREGFSRALLHPKDNPNEGLLMERRGLGWKVVRLQVNTLPK
>NC_014212.1|WP_013157702.1|1216080_1216680_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MQKEISREQAFVRHLRQRSEPADLARMRRALGDPGQEVIPVVEGFLGRIQDEREDHRERMVYYLVAGLWATTVSSSELEQFRKKPEEEPEVSQSEESDVSKGYRRTLGHAIAQLYLARDQSKSIEQRFIALLDADEEQLPYRIRQMVRLLKSEEGIPIYWSELLRDLLAWDYERRPVQQKWARAFYRTVAKETERGEEE
>NC_014212.1|WP_013157701.1|1214411_1216097_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MHTFNLITQPWIPVREGNQLKEVSLEQALLEGRRFERIEDPSPLVTVALYRLLLAILHRALQGPENSDEAAKWFSNGFDAEKIRDYLAKHQDRFDLFHPERPFYQVPDFTLERSCRSWTVLAPELNSDNNKVLFDHTVTSRPRPLHPAEAARLLVANQTFALSAGKSVLCHTATAPVATAALALMLGENLHETLCLNLVSYPKSEYERDFATWEREPLRVSDLKNCEAARATPKGIVHRYTWLSRAVRLDPEEGNGQADDPLSGRFASVHRTDDPLSGQGTHAPVHPGRSPAGQTAHAAVYRTVVRWIAYASGIRYEEAAIRPDPMVAFRPDPKDLSKQYPLGFREGRALWRDFASLLPRPGSAHSPRVVEHARNVYRALGTRFKGRGIPVMVAGQANDQAKVELWRGEVYRLPEAILSDKDIWRFVEENLERAEEMGRALNGAARALATQLLTLGDRQPHKDDVIKLMQSFPHQAAYWSALEGQFANWIVRLGPDFEEQQARLEQDWLKTLQREALQAWQLTKLAAGDDARALRAIHKSEGILLAYIYGKGKEEAGAKGN
>NC_014212.1|WP_169307849.1|1214181_1214358_+|hypothetical-protein
MLYGILADDELVNLVMDAAHAANVSNAEKLRAELELRLVEYRLQEQYGSLDEWDCDTS
>NC_014212.1|WP_041653157.1|1211245_1213960_+|CRISPR-associated-helicase/endonuclease-Cas3
MSLSDAAKALWAKSDRNKDGGEWHPLIAHLLDVAACAEVILEREPKKTLELYAQDLGLPLEQAKAWVCALAGLHDIGKASPAFQQKWPEGKKRVCDAGLTWTVDPTPPPNDVSHSVISEEVLPELLEERGWVLGAAQNVAAAVGEHHGFRATRQDLDDVTSREKGKGVWDEVRQELFEAVLEVLEVGNAPNVSIYKGAAFERLAGLASFADWIGSSLDFHPLGDDLAQYYQNAKARAAQKLDDIGWFQREALMKEPQTLEAVFAYLGKPDQPFKPRPLQAVLERLLEGINTPALFLVEAPMGEGKTEAAFYAHLRLQSANGHRGMYISLPTQATGNLMFERAKEFLGRYGKSRRLDLQLLHGASELVEEYQKIRVRPNTPEGGEEGVEAQVWFSHRKRGLLSEYAVGTVDQALLGILPTRHQFVRLWGLGNRVVVLDEVHAYDTYTSGLIESLVRWLWALDSSVVLMSATLPKAKREALLKAFGAGEIPKVEDKPKPYPRITRVVKGDPKPMVETFAARKQPTLALKALPLDLEALAGKALEQAQSGGCVACIVNTVQRAQDLYQALVGKADGVEVHLFHARYPLEERLERERTVLAKFGKPGQRPQKAVLVATQVVEQSLDLDFDVMFTDLAPVDLVLQRAGRLHRHERDPKERHAHTKPVLWVAGLEAEGVPNFGSAERIYERYILLRSWLALRSRTHIDLPGDIDRLVQEVYSEPEPQGLSEEWKTALEQARTRMEQRNARDQDEAAYAPFGEPCETDWLDPQTFPKLPDDEPNPDDDPSLLHTRKGSPSATVVLLHKVGGQLCLDASGKEPVSLARKLELAEAKRVFARSVKLSRHELTSNDFAALKAHRKSQGLAAKVWSETPLLAHAHPVVLEEGRAVLGELELELHPELGVVYRSAL
>NC_014212.1|WP_013157232.1|1222175_1223312_-|transposase
MQFTTVGREIWRGARQAQRLAEANASDPEVQERLRKLRLVKALRESKKSWKEIQDLVGISRATYHRWQKALKEKGLAGLKPRSRRPKHLRTKVHWTPGLLIRIETLRKENPTWGRWSIWLTLRKEGFQMSERTVGRILAYLEKHRRIESVAGYLARTQRGKLKRRVNRPYAKRKPRGYEARAPGDLVQVDTLTLTLGPGSMVKHFSAIDLHSRFVLAEVHSRATAKLSEGFLSLLLARAPFPIRAIQVDGGSEFMAEFEEACCALGIALFVLPPRSPKLNGHVERMQRTFKEEFYTRPLPTPLSELQAELDTYLDYYNRRRPHMALGGLAPLEFLAKMQEESVPQRVSNVLTDYRVLLRWSFWLRCKRSRFLKESQMC
>NC_014212.1|WP_013157709.1|1223445_1223817_+|hypothetical-protein
MSWREVLVIHKTLRGIGWESLLVDRGESGYRNEFLPDGRIVYPGEGLRGNQQPTGGNRILLEAYADKRPMRVFAREGPNRWCDLGKYRVEKVQYSWLPPERRYIYRFTLTPELSTDYESKLWL
>NC_014212.1|WP_013157710.1|1223882_1224503_-|phosphoribosylanthranilate-isomerase
MTRAKICGITRPEDALLAERLGAWAVGFILVPGTKRYRPPEHARRISEQLGPFICRVGVFQDSPPEAVLAHMAQAKLQVVQFHGFEPPAWAEEVRRHYPLIKAFKLSGPADAAMLEQALTYPCDALMLDGVNPGSGQGYPLAWLEPFLGHPRLIVAGGLNPENLPSVLALQPYAVDVSSGVEESPGVKDGQKVRSFLDVVSRSAQL
>NC_014212.1|WP_013157711.1|1224625_1225363_+|glycosyltransferase-family-2-protein
MISILVPTRGRPALLRRALRSLQLQSYVQWEALVADDGEGEGVEAAQSLQDPRIRPFLNPGKGQVEARNAGLERAHGEVVALLDDDDWWEDEYHLHRVLRALRNGPALVYRGGWLVHEREGIELERYPFDFAATPQSLRQDNTLLASAVAYPRILHEQLGKFDPEMADYWDWDWYLRVVAAGYPLLRLPGRGVAVAQHGANASYGARLAERQANLDRLVRKHGLSGVVLKDHRSLLEPGQAPAIP
>NC_014212.1|WP_174263499.1|1225365_1227219_-|polyphosphate-kinase
MAPPLRISQEAAWLQFNRRVLLQTERPDFPVLERLRFLEIWAANLDEFFSARISRAFLEERGSEGYQALLLEAKSQADFAEDCYRRFLPELEPLGMRVLPPDKLSKAELRYFGAYLAEEVAPKTDLIQPEGLADLSSRALYFASGEGLLQTLIRLPESIPRLLPIPGREGSFVRLGELVRHRNDLFLPYPAKLYELRVIRLASLERSRVDWDELPEALEARLDGKVSHLEVEEDFPPHWAEAIREALGLAAEEVFRLAPPLDLRFVNILVAAGPAKERFAPRPPEKPRRFIKNPWTTLDEQDLLLYHPYQDYRAVEAFAWAAANDPKVEAIRATLYRLGRENGVAEALISAAKAGKDVAVLLEARARFDELLNLYWSLRFRKAGVRVLPLPAKKVHAKALWVRRGRRAYAHLGTGNYNALNGSLYTDLSLFTANPKVTKEVAAFFRALEARHAPAPTLIKTGPAIREALLEAIQGEAHKKGQIILKFNHLTDPTILAALEEAAEKGARVDLIVRSTLTLLHPKFHARSLVGRYLEHARVAAFKNKGKWTVWAGSADLMPRNLDRRYELFFPVLDPEAKRQVLRLLKSQLKDDVNTFILYHDGSQKALWKGKHNAQQL
>NC_014212.1|WP_013157713.1|1227347_1228853_+|Ppx/GppA-family-phosphatase
MQRIGIVDLGSGTSRLVVFAYEPGKHFRLVDEIREPVRLGEGLGQGGRLSSAAIERAISALRLYADFAQATTLDRLEAIATSALRDAENGPEFLQRIQEIGLPVRVLSGAEEAQYGVLAVANSFAWEDAWVMDLGGGSAQISRMKGRRYASGGAYPLGAVRLSERFLRSDPPKKSEIEELESFVRKELKEILKRLKREPLPLVAMGGTVRNLAKLAQKRRHYPLDILHGYWLSREDLENPLEALLRQSVAERREAEGLQPDRADVIPAGGLVYRTVLREAGLEGLWISGQGVREGYFYQYFLPPPHLVPDVRGFSVRNLFARYPQEIAHTARVRNFCRQLFRALAPLHGYGPPEERLLDEAALLHDIGMSVGYYDHHKHGEYLVMGSALPGLTHREQALLGLLVRYHRKGEPKLGSYKPLMLPDDGKRLERLAALLRLAEYLERSRAGRVEALAITLESKRVRLGLEAAEEPWVELAEVRKQQGLFRKAFGRELEVYWKHP
>NC_014212.1|WP_013157714.1|1229207_1229693_+|phosphohistidine-phosphatase-SixA
MQLYLIRHAIAEDTAPEGRKDDARPLSEEGVRRFRQVVKGLDRLEVRFSKLYHSPKLRAVQTADLLMKLVDGESEVMPALAEPPQEILLAALAGFGKEDRVGMVGHEPWLSELCAWLVLGDRQKATAFILKKGGIARLEGEPEPGKMQLLALLPPSVLRAI
>NC_014212.1|WP_013157715.1|1229715_1230399_+|CHAD-domain-containing-protein
MITPTRWLLHLENHLPVARKGDDPEGVHQVRVAGRRLRVWLELGGYQVLHDDLRWLVRGAGKVRDLEVMLHSPLPKSLAAWLAEKLQAAREELTPMLDSPRLMGLTRALHNLPPLPISEAEKRLERFERRVQKREATWNATRSFEDLHALRRALRRLRYAREYLEQDVEDLKALQEALGQLNDAEVALRHLEEFEAAGGRAAPSYRKLLETQREKGLAAARELLVKG
>NC_014212.1|WP_013157716.1|1230388_1230754_-|glyoxalase
MIQGLDHVQLAMPHGEETQARAFYAELLELTEIPKPQKLLHRGGVWFKLADNRELHLGIEEPFQPAKKAHPAFVVTEIRRLARRLEKAGYPVQWDEMIPGCRRFYTTDPFGNRLEFLEFIP
>NC_014212.1|WP_013157717.1|1230844_1231618_-|enoyl-CoA-hydratase/isomerase-family-protein
MSVLTRDHGSLRILTLNDPQRRNPLSPEMVSGLLKALEAAEQEPSVRALILTGAGSAFSAGADLEFLKTVTTAGAEANYAHSRELMRLFHRVYTFPKPTIAAIQGPAVAGGAGLATACDLAVLSETARIGYTEVKIGFVAALVGVILVRNVGEKHAKELLLTGKLVSAREAYRMGLVNRVVPQEQVLDEALGLAEEVIAGAPTSLALTKELLHALPGMGLEDGFRLATIANAWVRETSDLAEGIAAFFEKRAPKFGV

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Crispr_ID: NC_014212_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014212_3

2315230-2316092

Orphan

III-A

Consensus_repeat	Method
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	PILER-CR
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	CRISPRCasFinder
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	CRT

11 spacers

The CRISPR arrays of NC_014212_3

>merge|NC_014212|3|2315230-2316092|PILER-CR,CRISPRCasFinder,CRT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACGGTCGTGTACGAAGAATAGCGTCGGGCCCCCCAGGAAAAAGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACCCGCCGGGCCCACTCCAAGGTGATCCGGGGGTATCCGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACTTTCGAGCCAGGCAATACTTATTCATATAAAGATGCTCTATAGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACACCACCCAGGGCGAGGAGTCTTCCGCCAGTCGCTCCAGGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACAGTTATTATTCTGTTTCTGGTGGGGTAAGTAGCTTATCGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACTAATGAACTCAATATTGAAACTATTTATCTAAATATTTCTCAAGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACTGCAGCTATTGGCACATTTTCAATCTGTGCCTGAATAAAAGGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACTCTTTTATATCTAGTTTTTTTAATTGTTCAGGAATTACATGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACAAATAAACTTAGTACAAAGACAATTTTATTGTCTTATTTTTGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACTCCTATAGCAAGTTTCATTTCTAGCAGGACGCGATCTCTATAGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACAATACTTCGTATCTACTGGTAACGTAATCAAAGAAAGACTTGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACC

>NC_014212|3|3|2315230-2316091|PILER-CR
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	GGTCGTGTACGAAGAATAGCGTCGGGCCCCCCAGGAAAAA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	CCGCCGGGCCCACTCCAAGGTGATCCGGGGGTATCC
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TTTCGAGCCAGGCAATACTTATTCATATAAAGATGCTCTATA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	ACCACCCAGGGCGAGGAGTCTTCCGCCAGTCGCTCCAG
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	AGTTATTATTCTGTTTCTGGTGGGGTAAGTAGCTTATC
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TAATGAACTCAATATTGAAACTATTTATCTAAATATTTCTCAA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TGCAGCTATTGGCACATTTTCAATCTGTGCCTGAATAAAAG
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TCTTTTATATCTAGTTTTTTTAATTGTTCAGGAATTACAT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	AAATAAACTTAGTACAAAGACAATTTTATTGTCTTATTTTT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TCCTATAGCAAGTTTCATTTCTAGCAGGACGCGATCTCTATA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	AATACTTCGTATCTACTGGTAACGTAATCAAAGAAAGACTT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC

>NC_014212|3|3|2315230-2316092|CRISPRCasFinder
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	GGTCGTGTACGAAGAATAGCGTCGGGCCCCCCAGGAAAAA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	CCGCCGGGCCCACTCCAAGGTGATCCGGGGGTATCC
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TTTCGAGCCAGGCAATACTTATTCATATAAAGATGCTCTATA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	ACCACCCAGGGCGAGGAGTCTTCCGCCAGTCGCTCCAG
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	AGTTATTATTCTGTTTCTGGTGGGGTAAGTAGCTTATC
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TAATGAACTCAATATTGAAACTATTTATCTAAATATTTCTCAA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TGCAGCTATTGGCACATTTTCAATCTGTGCCTGAATAAAAG
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TCTTTTATATCTAGTTTTTTTAATTGTTCAGGAATTACAT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	AAATAAACTTAGTACAAAGACAATTTTATTGTCTTATTTTT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TCCTATAGCAAGTTTCATTTCTAGCAGGACGCGATCTCTATA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	AATACTTCGTATCTACTGGTAACGTAATCAAAGAAAGACTT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACC

>NC_014212|3|3|2315230-2316091|CRT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	GGTCGTGTACGAAGAATAGCGTCGGGCCCCCCAGGAAAAA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	CCGCCGGGCCCACTCCAAGGTGATCCGGGGGTATCC
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TTTCGAGCCAGGCAATACTTATTCATATAAAGATGCTCTATA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	ACCACCCAGGGCGAGGAGTCTTCCGCCAGTCGCTCCAG
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	AGTTATTATTCTGTTTCTGGTGGGGTAAGTAGCTTATC
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TAATGAACTCAATATTGAAACTATTTATCTAAATATTTCTCAA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TGCAGCTATTGGCACATTTTCAATCTGTGCCTGAATAAAAG
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TCTTTTATATCTAGTTTTTTTAATTGTTCAGGAATTACAT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	AAATAAACTTAGTACAAAGACAATTTTATTGTCTTATTTTT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	TCCTATAGCAAGTTTCATTTCTAGCAGGACGCGATCTCTATA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	AATACTTCGTATCTACTGGTAACGTAATCAAAGAAAGACTT
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014212.1\|WP_013158698.1\|2321219_2322266_-\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NC_014212.1\|WP_083771672.1\|2320101_2320287_+\|putative-addiction-module-antidote-protein	unknown	unknown	gnl\|CDD\|188241
NC_014212.1\|WP_013158701.1\|2324323_2324851_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl\|CDD\|274750
NC_014212.1\|WP_013158685.1\|2308091_2308538_-\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|235418
NC_014212.1\|WP_013158699.1\|2322276_2323473_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173844
NC_014212.1\|WP_041653483.1\|2324847_2325735_+\|methyltransferase	unknown	unknown	gnl\|CDD\|225370
NC_014212.1\|WP_041653480.1\|2313403_2314756_+\|magnesium-transporter	unknown	unknown	gnl\|CDD\|225148
NC_014212.1\|WP_013158684.1\|2306820_2307612_+\|hypothetical-protein	unknown	unknown	unknown
NC_014212.1\|WP_013158687.1\|2309392_2309884_-\|16S-rRNA-processing-protein-RimM	unknown	unknown	gnl\|CDD\|184352
NC_014212.1\|WP_013158700.1\|2323547_2324198_-\|NERD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377990
NC_014212.1\|WP_013158686.1\|2308648_2309371_-\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	unknown	unknown	gnl\|CDD\|234581
NC_014212.1\|WP_013158690.1\|2310464_2311772_-\|signal-recognition-particle-protein	unknown	unknown	gnl\|CDD\|236780
NC_014212.1\|WP_169307859.1\|2312054_2312597_+\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|367619
NC_014212.1\|WP_013158689.1\|2310184_2310436_-\|30S-ribosomal-protein-S16	unknown	unknown	gnl\|CDD\|234588
NC_014212.1\|WP_148225974.1\|2316096_2316984_+\|IS982-family-transposase	unknown	unknown	gnl\|CDD\|372648
NC_014212.1\|WP_148226057.1\|2317805_2318171_+\|hypothetical-protein	unknown	unknown	unknown
NC_014212.1\|WP_013158692.1\|2312600_2313143_+\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|226074
NC_014212.1\|WP_013158696.1\|2319645_2319786_-\|hypothetical-protein	unknown	unknown	unknown
NC_014212.1\|WP_013158697.1\|2320260_2321199_-\|agmatinase	unknown	unknown	gnl\|CDD\|212537
NC_014212.1\|WP_013158688.1\|2309899_2310118_-\|KH-domain-containing-protein	unknown	unknown	gnl\|CDD\|224750

Protein	Function_ID	Function_description	E-value
NC_014212.1\|WP_013158698.1\|2321219_2322266_-\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.79626e-105
NC_014212.1\|WP_083771672.1\|2320101_2320287_+\|putative-addiction-module-antidote-protein	gnl\|CDD\|188241	TIGR02684, conserved_hypothetical_protein, probable addiction module antidote protein. Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the downstream member of a gene pair. It is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, are located often with prophage regions, but also both in integrated plasmid regions and in housekeeping gene regions. Analysis suggests that the gene pair may serve as an addiction module. [Mobile and extrachromosomal element functions, Other].	3.0331e-24
NC_014212.1\|WP_013158685.1\|2308091_2308538_-\|50S-ribosomal-protein-L19	gnl\|CDD\|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	2.79339e-65
NC_014212.1\|WP_041653483.1\|2324847_2325735_+\|methyltransferase	gnl\|CDD\|225370	COG2813, RsmC, 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis].	1.32763e-19
NC_014212.1\|WP_041653480.1\|2313403_2314756_+\|magnesium-transporter	gnl\|CDD\|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	1.99677e-140
NC_014212.1\|WP_013158687.1\|2309392_2309884_-\|16S-rRNA-processing-protein-RimM	gnl\|CDD\|184352	PRK13829, rimM, 16S rRNA-processing protein RimM; Provisional.	1.7411e-88
NC_014212.1\|WP_013158700.1\|2323547_2324198_-\|NERD-domain-containing-protein	gnl\|CDD\|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	1.39832e-18
NC_014212.1\|WP_013158686.1\|2308648_2309371_-\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	gnl\|CDD\|234581	PRK00026, trmD, tRNA (guanine-N(1)-)-methyltransferase; Reviewed.	1.84793e-146
NC_014212.1\|WP_013158690.1\|2310464_2311772_-\|signal-recognition-particle-protein	gnl\|CDD\|236780	PRK10867, PRK10867, signal recognition particle protein; Provisional.	0
NC_014212.1\|WP_169307859.1\|2312054_2312597_+\|DUF305-domain-containing-protein	gnl\|CDD\|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	2.50077e-07
NC_014212.1\|WP_013158689.1\|2310184_2310436_-\|30S-ribosomal-protein-S16	gnl\|CDD\|234588	PRK00040, rpsP, 30S ribosomal protein S16; Reviewed.	8.50243e-38
NC_014212.1\|WP_148225974.1\|2316096_2316984_+\|IS982-family-transposase	gnl\|CDD\|372648	pfam13612, DDE_Tnp_1_3, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contains three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	6.08322e-13
NC_014212.1\|WP_013158699.1\|2322276_2323473_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	8.51618e-120
NC_014212.1\|WP_013158692.1\|2312600_2313143_+\|DUF305-domain-containing-protein	gnl\|CDD\|226074	COG3544, COG3544, Uncharacterized protein conserved in bacteria [Function unknown].	4.22565e-15
NC_014212.1\|WP_013158701.1\|2324323_2324851_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl\|CDD\|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	1.3793e-34
NC_014212.1\|WP_013158697.1\|2320260_2321199_-\|agmatinase	gnl\|CDD\|212537	cd11589, Agmatinase_like_1, Agmatinase and related proteins. This family includes known and predicted bacterial agmatinase (agmatine ureohydrolase; AUH; SpeB; EC=3.5.3.11), a binuclear manganese metalloenzyme, belonging to the ureohydrolase superfamily. It is a key enzyme in the synthesis of polyamine putrescine; it catalyzes hydrolysis of agmatine to yield urea and putrescine, the precursor for biosynthesis of higher polyamines, spermidine, and spermine. Agmatinase from Deinococcus radiodurans shows approximately 33% of sequence identity to human mitochondrial agmatinase. An analysis of the evolutionary relationship among ureohydrolase superfamily enzymes indicates the pathway involving arginine decarboxylase and agmatinase evolved earlier than the arginase pathway of polyamine.	1.0491e-110
NC_014212.1\|WP_013158688.1\|2309899_2310118_-\|KH-domain-containing-protein	gnl\|CDD\|224750	COG1837, COG1837, Predicted RNA-binding protein (contains KH domain) [General function prediction only].	5.9521e-18

>NC_014212.1|WP_041653480.1|2313403_2314756_+|magnesium-transporter
MNVQAGWQALQEALAEGDAGLVRQALGELYPQELLDHWDELSREHRFTVLTLLPPEEAAEVFSHLEEDEQAELLKALPPWRVKELLGELSLDDLTDALQAVEEENPQQAEALLDQLDPETRAEVEELSEYEEDEAGGLMTPEYIALRDSMTVDEVFRFLRRAAPDAEQVYYLYVVDAANRLEGVVSLRDLIVADPKTKVREIMNPDVVRVRTDTDQEEVARLMADYNFTVLPVVDEEGVLSGIITIDDVVDVIQEEATEDIYRLGAVESPELVYSRSSVWDLWSARIRWLVILVIGAMFSSSILEGFQNTLQAVTALTFYITVLLGAGGNTGNQSSTIIVRALATGDVRGRDWWRILLKELSVGAMLGITLAILLSIKVLIDGHGEILLVVAASLAVLMTVTNILGALLPIGIKKIGLDPALISNPLIATLSDITGLMIYLSMARWLLHM
>NC_014212.1|WP_013158692.1|2312600_2313143_+|DUF305-domain-containing-protein
MGKLLGFIVLAGLALGCGFSNSDIWGVLNRSPSRTFDRVLLSMLIPHYQGMLDMAEAYLPQAPNPQVRNWVQALIKDRKKRLNEWKTLIQQLGGLEPTAEATMQGEMYKDWVNFREGQKSEKVHSVFASLMLTNHFSTVNMAKMVEARSRDPKIEKLAQALIATETAHLEKLQALLIRNQ
>NC_014212.1|WP_169307859.1|2312054_2312597_+|DUF305-domain-containing-protein
MRRLALLLALFSPGWACGFQAPKIWAMLWETPAARFDRTFLSLMQNHYEQTKGMGERFLSQISDPKLKSWTQILINDHKTVLKEIQAELSSLGGTDAKAVEVMKSEMALDWEGLQTGAREGKANETYPGWMVTNGFSAIGMAQQALERTKNPKVRELARQIVAAESNRVEQLQIYLMGGR
>NC_014212.1|WP_013158690.1|2310464_2311772_-|signal-recognition-particle-protein
MFETLSQRIRAAVDKLRGRGRISEADLKTTLREIRMSLLEADVNFEVAKAFVNAVQEKALGAQVLESLTPAEQILTIVYEELVQTLGGEAKQPTLKSEGNLWFMVGLQGSGKTTTSGKLAAFYKAKGRRPLLVAADTQRPAAREQLRILGEKVGVPVLEVADGERPEVTARRLREHLTFDYRDLVIVDTAGRLQIDEALMGELAKLKEVLRPTETFLVIDAMTGQEALGVSRTFDERVGISGLILTKLDGDARGGAALSARYVTQKPIVFAGVSEKIEGLEPFYPDRLASRILGMGDLQTLLEKAKAVELEGPLKTPGEITLEDLITQMRQMRKMGSFADILKMIPGVSRALPPGFTVDEKAINRLEAIVLSMTREERRDPRILNASRRKRIAAGSGTSVQEVNRLIKTFEETKSMMKSLAKQKGRGAFRNPFGR
>NC_014212.1|WP_013158689.1|2310184_2310436_-|30S-ribosomal-protein-S16
MTKIRLSRFGSKGNPHYRIVVVDERNKRDGAYIERIGYYDPRKTTKDWLKVDAERAKYWLGTGAQPTETAKKLLKQAGVIEGK
>NC_014212.1|WP_013158688.1|2309899_2310118_-|KH-domain-containing-protein
MKDLVEYLAKAVVDQPEAVRVDERRGREGLIYYVETAPSDKGRLIGRQGRVIESIRTVVRSFAKGRVSVEVR
>NC_014212.1|WP_013158687.1|2309392_2309884_-|16S-rRNA-processing-protein-RimM
MRRIEVGRIGSPYGLKGGFKFRGEPWVEDLPRIYLQDLGYRTIEEAYWVGEELVLHLSGVKHRTDAEALVGLLVYADEGDLPELEEGSFYYYQLLGRTVFVDGEPFGEVAEVQEAAAQDLLVIKRFGTSLRALSRTYLVPFQAPYVVVKDDGIHIEAIPGLFD
>NC_014212.1|WP_013158686.1|2308648_2309371_-|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD
MRYTILTLFPALIRPWTEESILQRAIERGLISVDVRDIRDYAEGKHRVVDDTPYGGGAGMVMRVDVVVRAIEAALPADEVILLSPAGKPFNQRMAEELARKDHLVLVAGRYEGIDARIEHFITREVSIGDYVLMGGEVAALAILEATARLIPGVIKEAQSHQQDSFSTGLLDYPHYTRPPEFRGLGVPEILISGHHAKIAEWRRKQALKRTRERRPELLEVAELTPQDLAWLDEFDAGSE
>NC_014212.1|WP_013158685.1|2308091_2308538_-|50S-ribosomal-protein-L19
MNRGALLKVVESKYTRADMPEFKAGDTVRVNYKVREGNRTRTQAYEGVVIKIKRNGFNSSFTVRKISFGEGVERVFPFNSPLIDSVEVVARGKVRRAKLYYLRELRGKAARIKSDRKRINEDVSARNAAAAEAAAEPAQAEVPTESQE
>NC_014212.1|WP_013158684.1|2306820_2307612_+|hypothetical-protein
MRWFWALLILSGTGLAQPYLHYAAPVGTSMVYSTFYGARAVPIEYFWPSSLPQPPRRYNLDIWPEGYVQEWRRVVAPGVEEVTRWEPLGYCLITSIFLSRYMAAERSSDVPMVYEASSQGKGGEVSPGCLAPPSPRSSSEILPAYQVPLEVGQRLQVEVAAPWPVGAKGQLNLIYLGQQEGVHRFSIRLQVPAQRVGELWVGTLAYQGEALYLLDGRLLSEKLYAKGVVFRLGATSGAFRVYLSREVNGQEEPSDAPPLVIRP
>NC_014212.1|WP_148225974.1|2316096_2316984_+|IS982-family-transposase
MICTVTKVYYVVCYLKWGKKREMVFIAMRNHPRYQHSLEELFLRVFILVDDWLKANQERFRLPVQANQVASYSELFTIALVGELLAQPYESVWYWLVRQNHRGLFPRLPEYSRYHRIVRNAEPLWAELAQSLAAKEDEDWGIEVIDTKPLPIAKGKRWEWAKMPEASKGFSTMGMVWGFKLHAVVSLGGLFRRWAFVPAHVHESRVVEGLLGRATLGDRAYVGTGVYCPSRKNMKRQTFWPRALSRLRKRIETSFSSLVRSLHLHVGQVKTFWSLRARVNLKIAAHNLMHSGVLV
>NC_014212.1|WP_148226057.1|2317805_2318171_+|hypothetical-protein
MRELVLSERYRLVALDAILLERRMEGEVEVTSFRYLSSPYTPRSLEALGNQLQAQLESRGYQMRCKTMNALPILGGPQYTLRMSRGNEGVGLFLRPLGEPDAYRLEVGPADPNPPLTCPAR
>NC_014212.1|WP_013158696.1|2319645_2319786_-|hypothetical-protein
MGEEIRMRPIRRYRAAELAGLLKGSPVPFAGLEAEREALAKHERGG
>NC_014212.1|WP_083771672.1|2320101_2320287_+|putative-addiction-module-antidote-protein
MAAALGDIVQARGMSQVAREAGLSRESLYKALSGEGNPEFATVMKVVKALGLRLRAEQVST
>NC_014212.1|WP_013158697.1|2320260_2321199_-|agmatinase
MRSSELPFTGPATFLKAPYRPLLEPWTADVGFLGLPYDFAVGYRPGARFAPNALREASGRYAPGSEGYFDLETETYRLGGLSLVDAGDVDPAQLEYTETFRRITEAARTLRKRVRLPVFVGGDHSVSYPILKAYDDLEELYVVQLDAHLDFSDSRNGTQYSNSSPFRRAAEDVPGLKHITAIGLRGLRTNPEAYRAAKARGHTLVTAARVREDLSWVLDQLPQGQKVYLSFDVDVLDPSIMPGTSSPEVEGLTYAEALAVVRRTITRNELVGFDLVELAPNWDSSGLSSLVGARLLAEVLCDWCSGADLFGP
>NC_014212.1|WP_013158698.1|2321219_2322266_-|phosphotransferase-family-protein
MTDQPATIRPGEELDIARLQSYLLKNLPGAKGDLEVLQFPRGFSNLTYLLRLGEQELVLRRPPFGANIKSAHDMGREYRILSALKPVYPKVPRPLLYCPDASVIGAPFYLMERLHGVILRNEPPRGLTPEVMRGVSQALVDALVELHTLDYQKAGLADLGRPEGYVSRQVSGWSQRYQNARTDDIPGLERAMAWLAENLPTESGAALIHNDFKYDNLMLAPDDLTRVIAVLDWEMATLGDPLMDLGTTLGYWAEAGDPPGLVSYGLTHVPGNLTRAELVAAYAERTGADVSNMVFYYVFGLFKVGVIMQQIYARYKQGLTQDARFGALIHLIREIGLMIDRALDTGKV
>NC_014212.1|WP_013158699.1|2322276_2323473_-|acyl-CoA-dehydrogenase-family-protein
MAASTADLVREVREFVREEILPLEPAFLHHGFAAVLPALREKRQEVKARGWWLPPFPREWGGMGLGLLEFARLSEELGRTPLGHYVFNTQAPDIGNMEVLLKHGTPMQKERFLKPLAAGEIRSSFAMTEPEHAGSNPVWMNTTAVLEGDHWVINGHKWYTTGFEGSAFCIVMCITDPDHPNPYARASQIIVPTDTPGFQHVRKIAVMGEQGEDWMSHSEIRLQGVRVPKENLLGERGRGFAIAQERLGPGRIHHCMRWVGICERSFELMCGYAAKRELSPGKPLGSRQAIQHMIAESKAEIHAARLMVLDAAEKVERQGAEGARVEISLIKFFVAGVLQRVLDRAIQVHGGLGMSDDLPLSFFYRHERAARIYDGADEVHKTVVARAVLKEYGLEVSL
>NC_014212.1|WP_013158700.1|2323547_2324198_-|NERD-domain-containing-protein
MALKHGRAGKTLRNKLGKVAVVLGMMGFSTWLIIKISVPWLAPVAPLLAALVIFRLLEDKDVSRNISALSKGYAGEAYVGKVLETLPSGWRVFHDLDLGGENVDHLVIGPGGVFSLEVKNYSGKVTATPNGLYNKGERQDKIVKQAWRQSHKLRELLGVEVVPILVFVGDELEGSRVGRLMVKRPRELVPFFRNLPKVWEYKEFLEVVRRAERLVK
>NC_014212.1|WP_013158701.1|2324323_2324851_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MRVLALDTATPYLVLGLNEAERAVRLGRRHAEALWTELEAFLADCRTSLREIEGIAVGQGPGSYTGLRIGVSAGLGLARGLGIPVVGVDTLVGVAMRYRGPVTVAHTTRNGLVYAATYVIEEGIKELHSPRRIPLEQLEPEGTFSLDEPPSGRALAHLGSQALRAGKRGIQAVYL
>NC_014212.1|WP_041653483.1|2324847_2325735_+|methyltransferase
MTLADYHRLLPVQYGNTRLFVKAGARGYPDPRYELMARVLEPFGERAVDLNPGVGLASVGLLEQIPVDLVETSRACLRCLEKSFAAHPGARVLRGLPWEVEAEAYDQAVLVIPAERGSRYVELALWGAAHSLRPGGRLWIAGDTKKGFETYFKQAQAQLGYGLVSHREGSLRVAVLEKEKPTPPRGSMWESFEAEIWGHPLSFRHLPGVFSTGHLDPASTLLLHTFFEDNWAEDVKGRTVLDLGGGYAGLSLPLAAAGASVTVAEDDWVSILSAQASFQANGLEGRVVHSDVEEA

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Crispr_ID: NC_014212_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014212_4

2317014-2317193

Orphan

III-A

Consensus_repeat	Method
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACA	PILER-CR
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_014212_4

>merge|NC_014212|4|2317014-2317193|PILER-CR,CRISPRCasFinder
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACAGATCCCGGCGAGATTGACCCCTCAACAGTAGTAAGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACACAAATCCGGGTACGCTCACTACCCTCCCCCCCTCGTCCGTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACT

>NC_014212|4|4|2317014-2317193|PILER-CR
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACA	GATCCCGGCGAGATTGACCCCTCAACAGTAGTAA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACA	CAAATCCGGGTACGCTCACTACCCTCCCCCCCTCGTCC
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAACT

>NC_014212|4|4|2317014-2317192|CRISPRCasFinder
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	AGATCCCGGCGAGATTGACCCCTCAACAGTAGTAA
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC	ACAAATCCGGGTACGCTCACTACCCTCCCCCCCTCGTCC
GTCGCAAACCAAAAGCCCCGTAAGGGGATTGCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014212.1\|WP_013158698.1\|2321219_2322266_-\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NC_014212.1\|WP_083771672.1\|2320101_2320287_+\|putative-addiction-module-antidote-protein	unknown	unknown	gnl\|CDD\|188241
NC_014212.1\|WP_013158701.1\|2324323_2324851_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl\|CDD\|274750
NC_014212.1\|WP_013158685.1\|2308091_2308538_-\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|235418
NC_014212.1\|WP_013158699.1\|2322276_2323473_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173844
NC_014212.1\|WP_041653483.1\|2324847_2325735_+\|methyltransferase	unknown	unknown	gnl\|CDD\|225370
NC_014212.1\|WP_041653480.1\|2313403_2314756_+\|magnesium-transporter	unknown	unknown	gnl\|CDD\|225148
NC_014212.1\|WP_013158687.1\|2309392_2309884_-\|16S-rRNA-processing-protein-RimM	unknown	unknown	gnl\|CDD\|184352
NC_014212.1\|WP_013158700.1\|2323547_2324198_-\|NERD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377990
NC_014212.1\|WP_013158686.1\|2308648_2309371_-\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	unknown	unknown	gnl\|CDD\|234581
NC_014212.1\|WP_013158690.1\|2310464_2311772_-\|signal-recognition-particle-protein	unknown	unknown	gnl\|CDD\|236780
NC_014212.1\|WP_169307859.1\|2312054_2312597_+\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|367619
NC_014212.1\|WP_013158689.1\|2310184_2310436_-\|30S-ribosomal-protein-S16	unknown	unknown	gnl\|CDD\|234588
NC_014212.1\|WP_148225974.1\|2316096_2316984_+\|IS982-family-transposase	unknown	unknown	gnl\|CDD\|372648
NC_014212.1\|WP_148226057.1\|2317805_2318171_+\|hypothetical-protein	unknown	unknown	unknown
NC_014212.1\|WP_013158692.1\|2312600_2313143_+\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|226074
NC_014212.1\|WP_041652564.1\|2325809_2327120_+\|methyltransferase	unknown	unknown	gnl\|CDD\|368316
NC_014212.1\|WP_013158696.1\|2319645_2319786_-\|hypothetical-protein	unknown	unknown	unknown
NC_014212.1\|WP_013158697.1\|2320260_2321199_-\|agmatinase	unknown	unknown	gnl\|CDD\|212537
NC_014212.1\|WP_013158688.1\|2309899_2310118_-\|KH-domain-containing-protein	unknown	unknown	gnl\|CDD\|224750

Protein	Function_ID	Function_description	E-value
NC_014212.1\|WP_013158698.1\|2321219_2322266_-\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.79626e-105
NC_014212.1\|WP_013158685.1\|2308091_2308538_-\|50S-ribosomal-protein-L19	gnl\|CDD\|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	2.79339e-65
NC_014212.1\|WP_041653483.1\|2324847_2325735_+\|methyltransferase	gnl\|CDD\|225370	COG2813, RsmC, 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis].	1.32763e-19
NC_014212.1\|WP_041653480.1\|2313403_2314756_+\|magnesium-transporter	gnl\|CDD\|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	1.99677e-140
NC_014212.1\|WP_013158687.1\|2309392_2309884_-\|16S-rRNA-processing-protein-RimM	gnl\|CDD\|184352	PRK13829, rimM, 16S rRNA-processing protein RimM; Provisional.	1.7411e-88
NC_014212.1\|WP_013158700.1\|2323547_2324198_-\|NERD-domain-containing-protein	gnl\|CDD\|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	1.39832e-18
NC_014212.1\|WP_013158686.1\|2308648_2309371_-\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	gnl\|CDD\|234581	PRK00026, trmD, tRNA (guanine-N(1)-)-methyltransferase; Reviewed.	1.84793e-146
NC_014212.1\|WP_013158690.1\|2310464_2311772_-\|signal-recognition-particle-protein	gnl\|CDD\|236780	PRK10867, PRK10867, signal recognition particle protein; Provisional.	0
NC_014212.1\|WP_169307859.1\|2312054_2312597_+\|DUF305-domain-containing-protein	gnl\|CDD\|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	2.50077e-07
NC_014212.1\|WP_013158689.1\|2310184_2310436_-\|30S-ribosomal-protein-S16	gnl\|CDD\|234588	PRK00040, rpsP, 30S ribosomal protein S16; Reviewed.	8.50243e-38
NC_014212.1\|WP_148225974.1\|2316096_2316984_+\|IS982-family-transposase	gnl\|CDD\|372648	pfam13612, DDE_Tnp_1_3, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contains three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	6.08322e-13
NC_014212.1\|WP_013158699.1\|2322276_2323473_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	8.51618e-120
NC_014212.1\|WP_083771672.1\|2320101_2320287_+\|putative-addiction-module-antidote-protein	gnl\|CDD\|188241	TIGR02684, conserved_hypothetical_protein, probable addiction module antidote protein. Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the downstream member of a gene pair. It is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, are located often with prophage regions, but also both in integrated plasmid regions and in housekeeping gene regions. Analysis suggests that the gene pair may serve as an addiction module. [Mobile and extrachromosomal element functions, Other].	3.0331e-24
NC_014212.1\|WP_041652564.1\|2325809_2327120_+\|methyltransferase	gnl\|CDD\|368316	pfam05175, MTS, Methyltransferase small domain. This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.	8.4631e-26
NC_014212.1\|WP_013158701.1\|2324323_2324851_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl\|CDD\|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	1.3793e-34
NC_014212.1\|WP_013158697.1\|2320260_2321199_-\|agmatinase	gnl\|CDD\|212537	cd11589, Agmatinase_like_1, Agmatinase and related proteins. This family includes known and predicted bacterial agmatinase (agmatine ureohydrolase; AUH; SpeB; EC=3.5.3.11), a binuclear manganese metalloenzyme, belonging to the ureohydrolase superfamily. It is a key enzyme in the synthesis of polyamine putrescine; it catalyzes hydrolysis of agmatine to yield urea and putrescine, the precursor for biosynthesis of higher polyamines, spermidine, and spermine. Agmatinase from Deinococcus radiodurans shows approximately 33% of sequence identity to human mitochondrial agmatinase. An analysis of the evolutionary relationship among ureohydrolase superfamily enzymes indicates the pathway involving arginine decarboxylase and agmatinase evolved earlier than the arginase pathway of polyamine.	1.0491e-110
NC_014212.1\|WP_013158692.1\|2312600_2313143_+\|DUF305-domain-containing-protein	gnl\|CDD\|226074	COG3544, COG3544, Uncharacterized protein conserved in bacteria [Function unknown].	4.22565e-15
NC_014212.1\|WP_013158688.1\|2309899_2310118_-\|KH-domain-containing-protein	gnl\|CDD\|224750	COG1837, COG1837, Predicted RNA-binding protein (contains KH domain) [General function prediction only].	5.9521e-18

>NC_014212.1|WP_148225974.1|2316096_2316984_+|IS982-family-transposase
MICTVTKVYYVVCYLKWGKKREMVFIAMRNHPRYQHSLEELFLRVFILVDDWLKANQERFRLPVQANQVASYSELFTIALVGELLAQPYESVWYWLVRQNHRGLFPRLPEYSRYHRIVRNAEPLWAELAQSLAAKEDEDWGIEVIDTKPLPIAKGKRWEWAKMPEASKGFSTMGMVWGFKLHAVVSLGGLFRRWAFVPAHVHESRVVEGLLGRATLGDRAYVGTGVYCPSRKNMKRQTFWPRALSRLRKRIETSFSSLVRSLHLHVGQVKTFWSLRARVNLKIAAHNLMHSGVLV
>NC_014212.1|WP_041653480.1|2313403_2314756_+|magnesium-transporter
MNVQAGWQALQEALAEGDAGLVRQALGELYPQELLDHWDELSREHRFTVLTLLPPEEAAEVFSHLEEDEQAELLKALPPWRVKELLGELSLDDLTDALQAVEEENPQQAEALLDQLDPETRAEVEELSEYEEDEAGGLMTPEYIALRDSMTVDEVFRFLRRAAPDAEQVYYLYVVDAANRLEGVVSLRDLIVADPKTKVREIMNPDVVRVRTDTDQEEVARLMADYNFTVLPVVDEEGVLSGIITIDDVVDVIQEEATEDIYRLGAVESPELVYSRSSVWDLWSARIRWLVILVIGAMFSSSILEGFQNTLQAVTALTFYITVLLGAGGNTGNQSSTIIVRALATGDVRGRDWWRILLKELSVGAMLGITLAILLSIKVLIDGHGEILLVVAASLAVLMTVTNILGALLPIGIKKIGLDPALISNPLIATLSDITGLMIYLSMARWLLHM
>NC_014212.1|WP_013158692.1|2312600_2313143_+|DUF305-domain-containing-protein
MGKLLGFIVLAGLALGCGFSNSDIWGVLNRSPSRTFDRVLLSMLIPHYQGMLDMAEAYLPQAPNPQVRNWVQALIKDRKKRLNEWKTLIQQLGGLEPTAEATMQGEMYKDWVNFREGQKSEKVHSVFASLMLTNHFSTVNMAKMVEARSRDPKIEKLAQALIATETAHLEKLQALLIRNQ
>NC_014212.1|WP_169307859.1|2312054_2312597_+|DUF305-domain-containing-protein
MRRLALLLALFSPGWACGFQAPKIWAMLWETPAARFDRTFLSLMQNHYEQTKGMGERFLSQISDPKLKSWTQILINDHKTVLKEIQAELSSLGGTDAKAVEVMKSEMALDWEGLQTGAREGKANETYPGWMVTNGFSAIGMAQQALERTKNPKVRELARQIVAAESNRVEQLQIYLMGGR
>NC_014212.1|WP_013158690.1|2310464_2311772_-|signal-recognition-particle-protein
MFETLSQRIRAAVDKLRGRGRISEADLKTTLREIRMSLLEADVNFEVAKAFVNAVQEKALGAQVLESLTPAEQILTIVYEELVQTLGGEAKQPTLKSEGNLWFMVGLQGSGKTTTSGKLAAFYKAKGRRPLLVAADTQRPAAREQLRILGEKVGVPVLEVADGERPEVTARRLREHLTFDYRDLVIVDTAGRLQIDEALMGELAKLKEVLRPTETFLVIDAMTGQEALGVSRTFDERVGISGLILTKLDGDARGGAALSARYVTQKPIVFAGVSEKIEGLEPFYPDRLASRILGMGDLQTLLEKAKAVELEGPLKTPGEITLEDLITQMRQMRKMGSFADILKMIPGVSRALPPGFTVDEKAINRLEAIVLSMTREERRDPRILNASRRKRIAAGSGTSVQEVNRLIKTFEETKSMMKSLAKQKGRGAFRNPFGR
>NC_014212.1|WP_013158689.1|2310184_2310436_-|30S-ribosomal-protein-S16
MTKIRLSRFGSKGNPHYRIVVVDERNKRDGAYIERIGYYDPRKTTKDWLKVDAERAKYWLGTGAQPTETAKKLLKQAGVIEGK
>NC_014212.1|WP_013158688.1|2309899_2310118_-|KH-domain-containing-protein
MKDLVEYLAKAVVDQPEAVRVDERRGREGLIYYVETAPSDKGRLIGRQGRVIESIRTVVRSFAKGRVSVEVR
>NC_014212.1|WP_013158687.1|2309392_2309884_-|16S-rRNA-processing-protein-RimM
MRRIEVGRIGSPYGLKGGFKFRGEPWVEDLPRIYLQDLGYRTIEEAYWVGEELVLHLSGVKHRTDAEALVGLLVYADEGDLPELEEGSFYYYQLLGRTVFVDGEPFGEVAEVQEAAAQDLLVIKRFGTSLRALSRTYLVPFQAPYVVVKDDGIHIEAIPGLFD
>NC_014212.1|WP_013158686.1|2308648_2309371_-|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD
MRYTILTLFPALIRPWTEESILQRAIERGLISVDVRDIRDYAEGKHRVVDDTPYGGGAGMVMRVDVVVRAIEAALPADEVILLSPAGKPFNQRMAEELARKDHLVLVAGRYEGIDARIEHFITREVSIGDYVLMGGEVAALAILEATARLIPGVIKEAQSHQQDSFSTGLLDYPHYTRPPEFRGLGVPEILISGHHAKIAEWRRKQALKRTRERRPELLEVAELTPQDLAWLDEFDAGSE
>NC_014212.1|WP_013158685.1|2308091_2308538_-|50S-ribosomal-protein-L19
MNRGALLKVVESKYTRADMPEFKAGDTVRVNYKVREGNRTRTQAYEGVVIKIKRNGFNSSFTVRKISFGEGVERVFPFNSPLIDSVEVVARGKVRRAKLYYLRELRGKAARIKSDRKRINEDVSARNAAAAEAAAEPAQAEVPTESQE
>NC_014212.1|WP_148226057.1|2317805_2318171_+|hypothetical-protein
MRELVLSERYRLVALDAILLERRMEGEVEVTSFRYLSSPYTPRSLEALGNQLQAQLESRGYQMRCKTMNALPILGGPQYTLRMSRGNEGVGLFLRPLGEPDAYRLEVGPADPNPPLTCPAR
>NC_014212.1|WP_013158696.1|2319645_2319786_-|hypothetical-protein
MGEEIRMRPIRRYRAAELAGLLKGSPVPFAGLEAEREALAKHERGG
>NC_014212.1|WP_083771672.1|2320101_2320287_+|putative-addiction-module-antidote-protein
MAAALGDIVQARGMSQVAREAGLSRESLYKALSGEGNPEFATVMKVVKALGLRLRAEQVST
>NC_014212.1|WP_013158697.1|2320260_2321199_-|agmatinase
MRSSELPFTGPATFLKAPYRPLLEPWTADVGFLGLPYDFAVGYRPGARFAPNALREASGRYAPGSEGYFDLETETYRLGGLSLVDAGDVDPAQLEYTETFRRITEAARTLRKRVRLPVFVGGDHSVSYPILKAYDDLEELYVVQLDAHLDFSDSRNGTQYSNSSPFRRAAEDVPGLKHITAIGLRGLRTNPEAYRAAKARGHTLVTAARVREDLSWVLDQLPQGQKVYLSFDVDVLDPSIMPGTSSPEVEGLTYAEALAVVRRTITRNELVGFDLVELAPNWDSSGLSSLVGARLLAEVLCDWCSGADLFGP
>NC_014212.1|WP_013158698.1|2321219_2322266_-|phosphotransferase-family-protein
MTDQPATIRPGEELDIARLQSYLLKNLPGAKGDLEVLQFPRGFSNLTYLLRLGEQELVLRRPPFGANIKSAHDMGREYRILSALKPVYPKVPRPLLYCPDASVIGAPFYLMERLHGVILRNEPPRGLTPEVMRGVSQALVDALVELHTLDYQKAGLADLGRPEGYVSRQVSGWSQRYQNARTDDIPGLERAMAWLAENLPTESGAALIHNDFKYDNLMLAPDDLTRVIAVLDWEMATLGDPLMDLGTTLGYWAEAGDPPGLVSYGLTHVPGNLTRAELVAAYAERTGADVSNMVFYYVFGLFKVGVIMQQIYARYKQGLTQDARFGALIHLIREIGLMIDRALDTGKV
>NC_014212.1|WP_013158699.1|2322276_2323473_-|acyl-CoA-dehydrogenase-family-protein
MAASTADLVREVREFVREEILPLEPAFLHHGFAAVLPALREKRQEVKARGWWLPPFPREWGGMGLGLLEFARLSEELGRTPLGHYVFNTQAPDIGNMEVLLKHGTPMQKERFLKPLAAGEIRSSFAMTEPEHAGSNPVWMNTTAVLEGDHWVINGHKWYTTGFEGSAFCIVMCITDPDHPNPYARASQIIVPTDTPGFQHVRKIAVMGEQGEDWMSHSEIRLQGVRVPKENLLGERGRGFAIAQERLGPGRIHHCMRWVGICERSFELMCGYAAKRELSPGKPLGSRQAIQHMIAESKAEIHAARLMVLDAAEKVERQGAEGARVEISLIKFFVAGVLQRVLDRAIQVHGGLGMSDDLPLSFFYRHERAARIYDGADEVHKTVVARAVLKEYGLEVSL
>NC_014212.1|WP_013158700.1|2323547_2324198_-|NERD-domain-containing-protein
MALKHGRAGKTLRNKLGKVAVVLGMMGFSTWLIIKISVPWLAPVAPLLAALVIFRLLEDKDVSRNISALSKGYAGEAYVGKVLETLPSGWRVFHDLDLGGENVDHLVIGPGGVFSLEVKNYSGKVTATPNGLYNKGERQDKIVKQAWRQSHKLRELLGVEVVPILVFVGDELEGSRVGRLMVKRPRELVPFFRNLPKVWEYKEFLEVVRRAERLVK
>NC_014212.1|WP_013158701.1|2324323_2324851_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MRVLALDTATPYLVLGLNEAERAVRLGRRHAEALWTELEAFLADCRTSLREIEGIAVGQGPGSYTGLRIGVSAGLGLARGLGIPVVGVDTLVGVAMRYRGPVTVAHTTRNGLVYAATYVIEEGIKELHSPRRIPLEQLEPEGTFSLDEPPSGRALAHLGSQALRAGKRGIQAVYL
>NC_014212.1|WP_041653483.1|2324847_2325735_+|methyltransferase
MTLADYHRLLPVQYGNTRLFVKAGARGYPDPRYELMARVLEPFGERAVDLNPGVGLASVGLLEQIPVDLVETSRACLRCLEKSFAAHPGARVLRGLPWEVEAEAYDQAVLVIPAERGSRYVELALWGAAHSLRPGGRLWIAGDTKKGFETYFKQAQAQLGYGLVSHREGSLRVAVLEKEKPTPPRGSMWESFEAEIWGHPLSFRHLPGVFSTGHLDPASTLLLHTFFEDNWAEDVKGRTVLDLGGGYAGLSLPLAAAGASVTVAEDDWVSILSAQASFQANGLEGRVVHSDVEEA
>NC_014212.1|WP_041652564.1|2325809_2327120_+|methyltransferase
MQFTTVGREIWRGARQAQRLAEANASDPEVQERLRKLRLVKALRESKKSWKEIQDLVGISRATYHRWQKALKEKGLAGLKPRSRRPKHLRTKVHWTPGLLIRIETLRKENPTWGRWSIWLTLRKEGFQMSERTVGRILAYLEKHRRIESVAGYLARTQRGKLKRRVNRPYAKRKPRGYEARAPGDLVQVDTLTLTLGPGSMVKHFSAIDLHSRFVLAEVHSRATAKLSEGFLSLLLARAPFPIRAIQVDGGSEFMAEFEEACCALGIALFVLPPRSPKLNGHVERMQRTFKEEFYTRPLPTPLSELQAELDTYLDYYNRRRPHMALGGLAPLEFLAKMQEESVPQRVSNVLTDYKALPSTDRFDIIISNPPFHLGGEVILDVAQAFVQAASSLLRSGGRFYLVANSFLKYEPLLEAAFGNLSTLRRGGYKVLRSEA

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Crispr_ID: NC_014212_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014212_5

2867641-2867720

Orphan

Consensus_repeat	Method
GCCACCGAACAGGCGGTAAAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014212_5

>merge|NC_014212|5|2867641-2867720|CRISPRCasFinder
GCCACCGAACAGGCGGTAAAGGCGGTACGGGAAAACCTGAGCAAAGTTCAGGCCCAAGCCACCGAACAGGCGGTAAAGGC

>NC_014212|5|5|2867641-2867720|CRISPRCasFinder
GCCACCGAACAGGCGGTAAAGGC	GGTACGGGAAAACCTGAGCAAAGTTCAGGCCCAA
GCCACCGAACAGGCGGTAAAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014212.1\|WP_013159191.1\|2868051_2868729_-\|bacillithiol-biosynthesis-deacetylase-BshB1	unknown	unknown	gnl\|CDD\|274915
NC_014212.1\|WP_013159180.1\|2854360_2855020_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_014212.1\|WP_013159193.1\|2869452_2870070_-\|glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|237704
NC_014212.1\|WP_083771681.1\|2871776_2872898_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226952
NC_014212.1\|WP_013159195.1\|2871142_2871778_-\|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl\|CDD\|273138
NC_014212.1\|WP_013159188.1\|2863173_2864115_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|234835
NC_014212.1\|WP_013159184.1\|2858756_2859500_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_014212.1\|WP_013159187.1\|2862172_2863144_-\|N-acetyl-gamma-glutamyl-phosphate-reductase	unknown	unknown	gnl\|CDD\|237004
NC_014212.1\|WP_041653595.1\|2875560_2877552_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NC_014212.1\|WP_148225990.1\|2868814_2869435_+\|hypothetical-protein	unknown	unknown	unknown
NC_014212.1\|WP_013159181.1\|2855553_2856654_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	unknown	unknown	gnl\|CDD\|176892
NC_014212.1\|WP_013159197.1\|2873051_2874647_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|215257
NC_014212.1\|WP_041652666.1\|2859554_2860703_-\|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ	unknown	unknown	gnl\|CDD\|235441
NC_014212.1\|WP_013159186.1\|2860693_2861968_-\|N-acetyl-alpha-D-glucosaminyl-L-malate-synthase-BshA	unknown	unknown	gnl\|CDD\|274914
NC_014212.1\|WP_013159189.1\|2864311_2864737_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_014212.1\|WP_013159200.1\|2878817_2881760_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_014212.1\|WP_174263514.1\|2874735_2875470_+\|ABC-2-family-transporter-protein	unknown	unknown	gnl\|CDD\|226953
NC_014212.1\|WP_013159194.1\|2870273_2871053_-\|ABC-2-family-transporter-protein	unknown	unknown	gnl\|CDD\|226218
NC_014212.1\|WP_174263513.1\|2857698_2858751_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
NC_014212.1\|WP_013159182.1\|2856816_2857647_+\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270248

Protein	Function_ID	Function_description	E-value
NC_014212.1\|WP_013159191.1\|2868051_2868729_-\|bacillithiol-biosynthesis-deacetylase-BshB1	gnl\|CDD\|274915	TIGR04001, thiol_BshB1, bacillithiol biosynthesis deacetylase BshB1. Members of this protein family are BshB1 (YpjG), an enzyme of bacillithiol biosynthesis; either BshB1 or BshB2 (YojG) must be present, and often both are present. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.51626e-70
NC_014212.1\|WP_013159180.1\|2854360_2855020_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.43682e-73
NC_014212.1\|WP_013159193.1\|2869452_2870070_-\|glycerol-3-phosphate-acyltransferase	gnl\|CDD\|237704	PRK14402, PRK14402, glycerol-3-phosphate acyltransferase.	1.52574e-101
NC_014212.1\|WP_083771681.1\|2871776_2872898_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226952	COG4586, COG4586, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	7.25094e-156
NC_014212.1\|WP_013159197.1\|2873051_2874647_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|215257	PLN02464, PLN02464, glycerol-3-phosphate dehydrogenase.	0
NC_014212.1\|WP_013159188.1\|2863173_2864115_-\|ornithine-carbamoyltransferase	gnl\|CDD\|234835	PRK00779, PRK00779, ornithine carbamoyltransferase; Provisional.	1.04486e-179
NC_014212.1\|WP_013159184.1\|2858756_2859500_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	8.08735e-150
NC_014212.1\|WP_013159187.1\|2862172_2863144_-\|N-acetyl-gamma-glutamyl-phosphate-reductase	gnl\|CDD\|237004	PRK11863, PRK11863, N-acetyl-gamma-glutamyl-phosphate reductase; Provisional.	0
NC_014212.1\|WP_041653595.1\|2875560_2877552_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	7.91265e-12
NC_014212.1\|WP_013159195.1\|2871142_2871778_-\|pyridoxamine-5'-phosphate-oxidase	gnl\|CDD\|273138	TIGR00558, Pyridoxine/pyridoxamine_5'-phosphate_oxidase, pyridoxamine-phosphate oxidase. This model is similar to Pyridox_oxidase from Pfam but is designed to find only true pyridoxamine-phosphate oxidase and to ignore the related protein PhzG involved in phenazine biosynthesis. This protein from E. coli was characterized as a homodimer with two FMN per dimer. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine].	3.55097e-113
NC_014212.1\|WP_013159181.1\|2855553_2856654_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	gnl\|CDD\|176892	cd08883, RHO_alpha_C_CMO-like, C-terminal catalytic domain of plant choline monooxygenase (CMO) and related aromatic ring hydroxylating dioxygenases. C-terminal catalytic domain of plant choline monooxygenase and related Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs, also known as aromatic ring hydroxylating dioxygenases). RHOs utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. Plant choline monooxygenase catalyzes the first step in a two-step oxidation of choline to the osmoprotectant glycine betaine. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.	4.06303e-75
NC_014212.1\|WP_013159200.1\|2878817_2881760_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_014212.1\|WP_041652666.1\|2859554_2860703_-\|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ	gnl\|CDD\|235441	PRK05388, argJ, bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ.	0
NC_014212.1\|WP_013159186.1\|2860693_2861968_-\|N-acetyl-alpha-D-glucosaminyl-L-malate-synthase-BshA	gnl\|CDD\|274914	TIGR03999, thiol_BshA, N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA. Members of this protein family are BshA, a glycosyltransferase required for bacillithiol biosynthesis. This enzyme combines UDP-GlcNAc and L-malate to form N-acetyl-alpha-D-glucosaminyl L-malate synthase. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	0
NC_014212.1\|WP_013159189.1\|2864311_2864737_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	7.87815e-11
NC_014212.1\|WP_174263514.1\|2874735_2875470_+\|ABC-2-family-transporter-protein	gnl\|CDD\|226953	COG4587, COG4587, ABC-type uncharacterized transport system, permease component [General function prediction only].	2.12386e-70
NC_014212.1\|WP_013159194.1\|2870273_2871053_-\|ABC-2-family-transporter-protein	gnl\|CDD\|226218	COG3694, COG3694, ABC-type uncharacterized transport system, permease component [General function prediction only].	4.49682e-88
NC_014212.1\|WP_174263513.1\|2857698_2858751_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	9.97989e-50
NC_014212.1\|WP_013159182.1\|2856816_2857647_+\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270248	cd13530, PBP2_peptides_like, Peptide-binding protein and related homologs; type 2 periplasmic binding protein fold. This domain is found in solute binding proteins that serve as initial receptors in the ABC transport, signal transduction and channel gating. The PBP2 proteins share the same architecture as periplasmic binding proteins type 1, but have a different topology. They are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the family includes ionotropic glutamate receptors and unorthodox sensor proteins involved in signal transduction.	6.24402e-53

>NC_014212.1|WP_013159189.1|2864311_2864737_+|MarR-family-transcriptional-regulator
MPWTVLTRMWKLMRDLRDETLPQLERLGLAPNDPWLLASIEHHHHPTEVVRLTQMPAPTVSQMLKRLEAEGLLVRSLDPSDLRRYHFELTARGYEVLKESRTLLMSAMERRLERLTPEQRRQFVELLDILAQSEGEKVGKE
>NC_014212.1|WP_013159188.1|2863173_2864115_-|ornithine-carbamoyltransferase
MVEAKQAVSSLKGRDFLSNLDLSPAEYRAVLDTAHAMKRGEFKGQRPLEGQTLAMIFEKPSLRTRTTFEVAMNHLGGHAVNLTNAEIGLGTREPVRDIAMNLERWVDAIMARVYLHSTLEDLAQYSSKPVINGLSDLLHPVQLLADYQTIEETFPDTRGLRVAYIGDGNNMANAHIQTAVLSGAKLTIATPRGYEPNALILMEALKLGADVTLTHDPKAAAEGAQVLYTDVWVSMGQEQEASQRRKIKDFAGFQVNPAMLDLIDEDGIFLHCLPAHYGEEVVEEATLHPKSRVFDQAENRLHAQKALLYHLLG
>NC_014212.1|WP_013159187.1|2862172_2863144_-|N-acetyl-gamma-glutamyl-phosphate-reductase
MGKPKIFIDGEAGTTGLQIRLRLAGRNDLELLSIDPAQRKDALERKRLLNQADVAILCLPDEAAKEAVAMIENPQTRVLDASSAHRVAEGWVYGFPELSPLQPDLIRQARFVANPGCYATGAIALLRPLVDAGLLPEGFAASVQGISGYSGGGRALIEAMEGKGEHRLAGDYRAYGLELTHKHIPEMTRYSRLLHEPIFTPAVARFAQGMLVMIPVHLWALPKGVRACELHAALAERYQGQRFVEVMPLETYGAHHPVLDPQALNNTNRMELFVFENPTREQALLVARFDNLGKGASGAAAQNLDLMLGTVEEHAYQVRGVAA
>NC_014212.1|WP_013159186.1|2860693_2861968_-|N-acetyl-alpha-D-glucosaminyl-L-malate-synthase-BshA
MNIAILCHASAGGSGVVATELAVALAKRGHQVHIVAPKRPFRLSRELDARSESFFQGMIRRIGRLLGVTPVDAAIGRERVQFHQIGTVDYPLFDDALSTLTAANTLARLVEEHHIEIVHAHYAIPHATSALLAREVSGGSFKVVTTLHGTDVTLLGLEPALRHTTRHAIEASDAVTAVSHDLARHTREAFGIHRPIHVIHNWVDPERFKPIHDPLLRARFAQPDEALLIHVSNFRRVKRPQDVIRVFARVAAKLPARLLMVGDGPERPECFALAQELEVMGRVQFLEFIPEVERVLGLADLMLMPSEQESFGLAVLEGMACGVPVVASRVGGLPEVVEEGKTGYLRAVGDIEGMAEAALEALSQPVHHQRLGEQARVRAVERFHPDVIVPQYLEVYREVLGLQHTESTTGAPSTQASEGVKLSA
>NC_014212.1|WP_041652666.1|2859554_2860703_-|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ
MGMRLPIGFRAGSTRAKIKPSGKPDLGLLVSGTPCSWAFVGTLNRAAAPSVNRGRKLYASGGLLQAIVVNAGNANCATGQAGVEADRRMAELAAVQLGIAPEAVLTGSTGVIGQPLPIEKIAAGLPQIQLGPEIDPFMEAILTTDLVPKMAEAELPGGARVVGICKGSGMIQPNMATMLAYILTDAAVSQAELRQGWKGVIDKSFNQVTVDTDTSTNDMAVLLANGASGEVPLPEFWAAVEGVCVSLARQLARDGEGATKLLTVKVNGALSDEEARKAALAVAASPLWKSAVYGNDPNWGRVMMAIGKSGAHFAVDRVRISLQGIPLYAGRVLEFDRASVSEAMRAEEVIVEVDLAEGEGQGVAWGCDLTEEYVRINALYTT
>NC_014212.1|WP_013159184.1|2858756_2859500_+|amino-acid-ABC-transporter-ATP-binding-protein
MSFLEIRNVHKHYGNVEVLRGINLDVEEHQVVCLIGPSGCGKSTLLRCVNGLEAISAGEIRLEGDRITGPGVDLDRLRREVGIVFQSFNLFPHMTVLQNVTLAPVQVLKIPRAEAEERAMGLLRRIGLEHKASEYPDRLSGGQQQRVAIVRALAMEPKLMLLDEITSALDPELVSEVLNLLRELASEGMTMILATHEMGFAKEVASKVCFLHQGVVHEEGPPEQIFGNPQKERTKEFLSSIIEAGRL
>NC_014212.1|WP_174263513.1|2857698_2858751_+|ABC-transporter-permease-subunit
MPKDATPLALAALVVSALVIAGAWATLEKLHKVLVQNKLEHPWVIALLALAALLLLLLLFPAVRGLRDAGQARAALGRHELIEARVKAAAAREWAWYAIGYAVAAALVFITIQFLLANDGAVGATFFKLSLIQDSFGLVLQAFWKNVWMFCVAEVFILVWGLVIAVARMVPGRAGSPIRFLATVYTDAFRGLPTIISIYLIALGLPLANVPLVRDWPPEWLAVLALTVSYGAYVAEVYRAGLDSIHPSQWAAARSLGLSFSQTLRFVIIPQAVRRIIPPLLNDFIALQKDTALVNVVGVIDGFNQAKIIASNRFNLSAVTTVAILFMLITIPQTRFVDRLLEQEKRRTRA
>NC_014212.1|WP_013159182.1|2856816_2857647_+|amino-acid-ABC-transporter-substrate-binding-protein
MSKKWVVLLALALASLSLAQKIGDCELTGKKGEYTIKPVVPGQLTVQTNLPAPGWWNGDTPQTIKSGFEYCLAANIAYRAGLDKVVVQNVSFDALVAGQTKAFDLALSQVTITDERKKVVDFSPPYFSSDQGLLVRKGTKVNSSNIKSLKIGVQQGTTAVDFVKNVLKVPAANIRVFPDTPNMFTALQARQVDVVMLDTAIVLVQAAKSNGALEVVGQYKTGESYGAIYPKNSPNRATFDRIIQALNADGTIKKLTQAYLAKEFGGDPTAIPYLKP
>NC_014212.1|WP_013159181.1|2855553_2856654_+|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha
MPELYPELYVHPDISQASTLPAAFYKDPAIFERAKEQVFARTWQWVGDTDDLKAPGTVKPFTLLEGFLDEPLVITRDHDDRLHLLSNVCTHRGMLVAETGDNARYLRCRYHGRRFGLDGCFQAMPEFEGVKGFPSESDHLPQVPFGLWRGKFLFASLDPAVPLEEVLKPIEERLGWLPLQQFYFEPARARDYLVRANWALYCDNYLEGFHIPFIHASLNAAIDYGSYTSEIYDWCNLQLGVAASGETAFELPQDSPDYGQRIGAYYYWVFPNLMLNFYPWGLSVNVVRPLGPELTKVSFLPYVWKPALLDSGAGAGLDRVEREDEVVVEAVQKGVKSRFYDRGRFSVAREQGVHHFHRLLAQALAP
>NC_014212.1|WP_013159180.1|2854360_2855020_+|response-regulator-transcription-factor
MPAKVLVVEDDPGIRMLVATTLQSAGLAVLEARDGVEAMDFIPEADLVVLDVGLPRQSGWEVLEAIRQNFGQLPVLMLTGHSDETNRVRGLESGADDYLTKPFSVRELAARVKALLRRSGRLGLIVMGSLKLSPGSREAWLDNDTLHLTPLEFDLLMTLAQAPGRIFSREELLVRHWGAEYEGTERVVDIYIGRLRKKLLTESDRLETVWGQGYRLRSD
>NC_014212.1|WP_013159191.1|2868051_2868729_-|bacillithiol-biosynthesis-deacetylase-BshB1
MAIDLLVIAPHPDDAELGCGGMLARAKAEGYSTAILELTQGEMGTKGTVQERLAEAEEAARILGLDYRGNLRLPDGGLADVPEQRQALGQALRNVRPRVVIAPWSADRHPDHVAAHHLSLSAVHFAGLSRAALQGQPHRVERIFFYPGNYAVTPSLLVDVSAYIETWQAALLAHQSQFHGEAASETVSLAGVEARRALRRAWGNYLGVAYAEPLVSLQPVLGVPW
>NC_014212.1|WP_148225990.1|2868814_2869435_+|hypothetical-protein
MVMVPSEDLTAGLSQAASLMDEGQELMHRMHELAEELRQVAAQLAQGIPAPAEAAQQLTQAAHAFEDWWRRAQKLVGGDLERSIPKVMQALEAHQQKLEMEIQRQKAMAVLEQVGSLSYGGKEEFMPLSEIQFEALGMLRALKGAEQLDDTALALAAGTHPYALLVRLIANPDLSDDDWQETYQAVKQSLGNELAVAAARGRLRLE
>NC_014212.1|WP_013159193.1|2869452_2870070_-|glycerol-3-phosphate-acyltransferase
MTWEIALILLLAYLFGSIPVGALVARARGIDIQKVGSGNIGATNVLRTLGPGPAAIVAFFDVFKGGIALLISRLAGLDGMVAGLVAVAAVLGHNYSIWLRFSGGKGVATSFGTLLVLDPWVALLTLPIGVTTMVLTRYVSAGSMIGGVASVVIAIGLGRPVWEVITLGLLAGLIFLTHRENIRRLQAGTERRLGEKSAEKTGAAG
>NC_014212.1|WP_013159194.1|2870273_2871053_-|ABC-2-family-transporter-protein
MRYWKLLNRFWGSALAAELEYRGNFALAAIAAVAMLAGSIFSLSLLYQGGYRPGGWKFDEALLVLGAFTILEGFSNTFLGPNLNRIVEQVQKGTLDFVLLKPVDSQFWLSTRFFSPWGLPNLLFGLGVWVYAGSRLGMGLSGYLLGLGLLGVASLLLYSLWFILGSTSIWFVKIYNVTEVLRGLLEAGRYPIGAYPALYRFFFTFVVPVAFLTTVPAEASLGRLEPPTLLLALGIALFVFAFARFFWRLALRSYTSASS
>NC_014212.1|WP_013159195.1|2871142_2871778_-|pyridoxamine-5'-phosphate-oxidase
MDLRNFRYDYTRGELNEADVSPDPVQQFGVWLEEALAAGLVEPYGMTLSTVGEQHRPSSRVVLLRGFSAEGFIFYTNYHSRKGRELQAHPYAALNFWWPPLERQVRIEGRVEKVSAEESDAYFASRPYESQAASASSPQSQPIPSREVLLQWIEQTKQRYPTQVPRPPHWGGYRLVPDYFEFWQGRKSRIHDRLAYTLEPGGSWKITRLAP
>NC_014212.1|WP_083771681.1|2871776_2872898_+|ATP-binding-cassette-domain-containing-protein
MQTGYTVHPGALQGRPLFALATSLGQRLKAPPFPPFYSVRVAIVTAENLAKSYPVALKDPGLAGTLRHFLARKYKQIEAVQGVTFQIAPGEIVGFLGPNGAGKTTTLKMLTGLIHPTAGRVEVAGHVPFRRESDFLKKITLVMGNKQQLIWDLPAADSFAINGAVYEIPDAELKKRIGELAEMLGLGGKLTQPVRKLSLGERMKAELLAALLHRPQVLFLDEPTLGLDVNAQMAVRDFLREYNRRYGATILLTSHYMADITALAERVMLIHQGSLIYDGGLQGLLERFAPYREVRLELERPVSREALERHGEVAELDAHQARLLLRREVLVEKVAQLLSELPVADLEVREPPVEEVIGRVFESGAKVETASSH
>NC_014212.1|WP_013159197.1|2873051_2874647_+|FAD-dependent-oxidoreductase
MNRTALLERLKNETFDLLVIGGGASGAGVALDAATRGLKVALVERLDFSEGTSSRSTKLIHGGVRYLEIAVKTLDRVQLNLVRDALHERSMLLKLAPHLTRPLWLLTPLYKLWEMPYYWTGLKLYDLLAGDARLQVSRYLGPQETLRRFPRVRSEGLVGAVAYQDGQFDDARYNLEVILTALEEGAVAVNYTEVTGLLKKNGKIAGAVVQDRLGGQEFEVGARVVVNATGPFSDSIRHLDDPAAPELVKASSGVHIVLGPTYSPPDTGLLIPHTEDGRVIFVLPWLGQTLVGTTDDPAEPTPHPRASEEEIAYILRQVEPYLGKVAREEVRAAWAGFRPLVAKAQAADTARLARDHLVQESASGLLTLTGGKWTTYRKMALDCVNYAVRRFGLQAGPSRTHERLLVGGWGFDPNGAQKLAQEYSLEPDIAQHLHRSYGSRAGQVAEIGQTFRLAPGYPYIESEVVYAARHELAQTPMDVLARRTRLAFLDTKAAEAALPEVAKLMAKELGWKAEERKAQENQTQERLAVAI
>NC_014212.1|WP_174263514.1|2874735_2875470_+|ABC-2-family-transporter-protein
MLEYRAELVLWAIAGLLPIILMGVWTQAAQGGGFGLTPDEFARYFLMVFLVRQLTVVWVIWDFEREVVEGRLSFKLLRPMDPVWDHVASHLSERAARMPFALLLLAIFFLLYPGALFVPSWEGILLGMIATAASFAMRFLMQYTFALVAFWTERASSLEEVWFILYLFLSGLVAPLSVFPEVVRNIALLTPFPYLVYFPASILAGQPVNIGQGFLVLLAWASFFFILNRWLWRKGLRQFSGMGA
>NC_014212.1|WP_041653595.1|2875560_2877552_+|hypothetical-protein
MGLLRLFVWMFALLGLALAQNPKGLVLPFAGPGGQTVAHALADGLRAAPPSLTALLIPDLPWRDSYDFAAGRIESLGGARLAREVSGADWLVVGEVGQDGWVTIYLSTPQESRRARFSRLELAQRWLELKLGLKPHPFPGLDYRLEETYQKMSQGDPSVIKGSALKGLYNSALETRQGKAPTPDLEALLPKPLLDFWSNLAQRHLPPAYQALSDFGSGQRPQALEAARKLADGLAYERLAALLIQRSAGQEDWRATARKLARIAPELPIAWEEVSFAAFDEDQPAEARDALLKALALLPRKPLYWTNLGWAYYLTGDKARSIQASSRALKLGESSPTPAYNLGLAKALYGDLLGARQAYDQALQLDDKQEFKAALEDLAKAKNPLLTYWQGYLSERTGEVAQAQAFYQRFAEANPQHPLAPAARRASRIHLETRISLEKLALQPEGPDARPFRAGEAVFPVVKLEGSPYLMRAPLVTRLLDENDRLLQENRKEITFRPMTAELIEKAPAVTLPKEGRYSLEVLYGDQKLSLSVIAGAPGLTRRLYAAGLQIRDLSDKPLLDEKEMLGPQGDRILLERTAFTLRQVAQFLRDKAKNDPQRRKELQELSKPLPQGPYAGQTVLELMGKAEEKVLRAFFEAATQNPELIGDNDVVNAFVNWLTGGG
>NC_014212.1|WP_013159200.1|2878817_2881760_+|excinuclease-ABC-subunit-UvrA
MDRIVVKGAREHNLKNITVELPRGKFVVITGVSGSGKSTLAFDTIYAEGQRRYVESLSSYARQFLGVMDKPEVESIEGLSPAISIDQKTTSHNPRSTVGTVTEVHDYLRLLFARVGTAYCPHCGRAIERQSASEITDKLFARPEGTRAILLAPVVRGRKGEYRKLFQQLQKEGYARARVDGIIYTLEEAADLKLEKYEKHDIDLVVDRVVLKEEERSRVAESVELALLRGEGLMRVFYPDEGLEELYSEKFACPEHGSVLEELEPRIFSFNAPYGACPDCSGLGYKQEFDPDLIVNPELSLAEGAIIPWAKGRDTGKGYLWDRLRALSEHMGFDLRTSFKDLPPSAKDAVLYGLPEPFEVVFKRNGRETLRFSVSYEGVIPWLESRYNETESEGLREALEAYMSLKACPSCGGTRYKREVLSVRVGSFNIAEVSNLPVREAKRFFEAVAAGRALEEAERMQAHRIRLEGLAEPQEPRELNTMQHQIALPILREVHSRLGFLEDVGLDYLTLDRGANTLSGGEAQRIRLATQVGSGLTGVLYVLDEPSIGLHPRDNLRLIGTLKKLRDLGNTLLVVEHDEETMREADWIIDMGPGAGVHGGKVVAEGELKDILSNPGSLTGAYLRGEKHIPVPPARRKGNGKWLIVKGAREHNLKNIDLHIPLGKFVAITGPSGSGKSTLIHDILYAALARDLMRAKTISGKFSGLEGIEHLDKVIEIDQSPIGRTPRSNPATYTGIFDEIRELFAKTPEARKRGYQSGRFSFNVKGGRCEACGGDGTVKIEMLFLPDLYVPCEVCKGKRYNKETLEVKLRGKSIADVLDMTVEEGLEFFQNVPTIARKLQLMVDVGLDYMKLGQPSPTLSGGEAQRIKLSTELGRKATGRTLYILDEPTTGLHFEDVAKLLAVLHRLVDAGNTVVVIEHNMDVVKTADWVVDLGPEGGARGGEIVAEGTPEAVAQKAGSPTGHFLLKIPEIARKLQVAAD

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Crispr_ID: NC_014212_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014212_6

3054251-3054470

Orphan

Consensus_repeat	Method
CTNCNCTTGAGTACCGGC	CRT

5 spacers

The CRISPR arrays of NC_014212_6

>merge|NC_014212|6|3054251-3054470|CRT
CTACCCCTGAGTACCGGCGCCAGCCGGGGGCCGATGGCCCTTCACTTGAGTACCGGCGCCAGCCGGGGGCCGATGGCCCTTCACTTGAGTACCGGCGCCAGCCGGGGGCCGATGGCCCTTCACTTGAGTACCGGCGCCAGCCCAGGTTACCGGCAAGCACTAGGCCCGCTTGAGTACCGGCCATCGCCGGGTCGCTATGCGACTTCACTTGAGTACCGGC

>NC_014212|6|4|3054251-3054470|CRT
CTACCCCTGAGTACCGGC	GCCAGCCGGGGGCCGATGGCC
CTTCACTTGAGTACCGGC	GCCAGCCGGGGGCCGATGGCC
CTTCACTTGAGTACCGGC	GCCAGCCGGGGGCCGATGGCC
CTTCACTTGAGTACCGGC	GCCAGCCCAGGTTACCGGCAAGCACTAG
GCCCGCTTGAGTACCGGC	CATCGCCGGGTCGCTATGCGA
CTTCACTTGAGTACCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014212.1\|WP_013159375.1\|3050958_3052068_-\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NC_014212.1\|WP_013159384.1\|3060006_3060723_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_014212.1\|WP_013159368.1\|3046071_3046437_+\|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl\|CDD\|376809
NC_014212.1\|WP_013159385.1\|3060833_3061130_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NC_014212.1\|WP_013159386.1\|3061215_3062286_-\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_014212.1\|WP_013159381.1\|3057344_3058073_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223489
NC_014212.1\|WP_013159370.1\|3046861_3047458_+\|sulfite-oxidase-like-oxidoreductase	unknown	unknown	gnl\|CDD\|239027
NC_014212.1\|WP_169307870.1\|3056413_3057025_+\|DUF3108-domain-containing-protein	unknown	unknown	gnl\|CDD\|378635
NC_014212.1\|WP_013159376.1\|3052196_3053006_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|235991
NC_014212.1\|WP_013159379.1\|3055136_3056243_+\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NC_014212.1\|WP_013159373.1\|3049658_3050330_-\|queuosine-precursor-transporter	unknown	unknown	gnl\|CDD\|376842
NC_014212.1\|WP_041653671.1\|3050399_3050930_-\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NC_014212.1\|WP_013159382.1\|3058160_3059270_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NC_014212.1\|WP_013159372.1\|3047798_3049574_-\|VanW-family-protein	unknown	unknown	gnl\|CDD\|225341
NC_014212.1\|WP_013159371.1\|3047484_3047793_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|308600
NC_014212.1\|WP_013159377.1\|3053122_3054091_+\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|184521
NC_014212.1\|WP_013159369.1\|3046456_3046789_+\|DUF190-domain-containing-protein	unknown	unknown	gnl\|CDD\|376875
NC_014212.1\|WP_083771732.1\|3059296_3060004_-\|3-keto-5-aminohexanoate-cleavage-protein	unknown	unknown	gnl\|CDD\|225785
NC_014212.1\|WP_013159387.1\|3062414_3062864_+\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|376504
NC_014212.1\|WP_013159378.1\|3054551_3055028_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439

Protein	Function_ID	Function_description	E-value
NC_014212.1\|WP_013159375.1\|3050958_3052068_-\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	4.84122e-83
NC_014212.1\|WP_013159384.1\|3060006_3060723_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.53837e-11
NC_014212.1\|WP_013159368.1\|3046071_3046437_+\|fluoride-efflux-transporter-CrcB	gnl\|CDD\|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	3.44089e-33
NC_014212.1\|WP_013159385.1\|3060833_3061130_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	7.40987e-13
NC_014212.1\|WP_013159386.1\|3061215_3062286_-\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	8.59277e-18
NC_014212.1\|WP_013159381.1\|3057344_3058073_+\|alpha/beta-hydrolase	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	4.93644e-06
NC_014212.1\|WP_013159370.1\|3046861_3047458_+\|sulfite-oxidase-like-oxidoreductase	gnl\|CDD\|239027	cd02109, arch_bact_SO_family_Moco, bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate. The specific function of this subgroup is unknown.	5.28673e-102
NC_014212.1\|WP_169307870.1\|3056413_3057025_+\|DUF3108-domain-containing-protein	gnl\|CDD\|378635	pfam11306, DUF3108, Protein of unknown function (DUF3108). This is a bacterial family of putative lipoproteins. Structure 3fzx, the first structural template for this large family including several homologs in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Bacteroides fragilis glyA is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA\|QNQDC, and a Phobius server prediction of non-cytoplasmic localization for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit Structure 2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.	1.72669e-06
NC_014212.1\|WP_013159376.1\|3052196_3053006_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|235991	PRK07327, PRK07327, enoyl-CoA hydratase/isomerase family protein.	1.29821e-162
NC_014212.1\|WP_013159379.1\|3055136_3056243_+\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NC_014212.1\|WP_013159373.1\|3049658_3050330_-\|queuosine-precursor-transporter	gnl\|CDD\|376842	pfam02592, Vut_1, Putative vitamin uptake transporter.	2.34322e-52
NC_014212.1\|WP_041653671.1\|3050399_3050930_-\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	1.49299e-81
NC_014212.1\|WP_013159382.1\|3058160_3059270_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	7.95156e-47
NC_014212.1\|WP_013159372.1\|3047798_3049574_-\|VanW-family-protein	gnl\|CDD\|225341	COG2720, COG2720, Uncharacterized vancomycin resistance protein [Defense mechanisms].	2.13981e-85
NC_014212.1\|WP_013159371.1\|3047484_3047793_+\|hypothetical-protein	gnl\|CDD\|308600	pfam03059, NAS, Nicotianamine synthase protein. Nicotianamine synthase EC:2.5.1.43 catalyzes the trimerisation of S-adenosylmethionine to yield one molecule of nicotianamine. Nicotianamine has an important role in plant iron uptake mechanisms. Plants adopt two strategies (termed I and II) of iron acquisition. Strategy I is adopted by all higher plants except graminaceous plants, which adopt strategy II. In strategy I plants, the role of nicotianamine is not fully determined: possible roles include the formation of more stable complexes with ferrous than with ferric ion, which might serve as a sensor of the physiological status of iron within a plant, or which might be involved in the transport of iron. In strategy II (graminaceous) plants, nicotianamine is the key intermediate (and nicotianamine synthase the key enzyme) in the synthesis of the mugineic family (the only known family in plants) of phytosiderophores. Phytosiderophores are iron chelators whose secretion by the roots is greatly increased in instances of iron deficiency. The 3D structures of five example NAS from Methanothermobacter thermautotrophicus reveal the monomer to consist of a five-helical bundle N-terminal domain on top of a classic Rossmann fold C-terminal domain. The N-terminal domain is unique to the NAS family, whereas the C-terminal domain is homologous to the class I family of SAM-dependent methyltransferases. An active site is created at the interface of the two domains, at the rim of a large cavity that corresponds to the nucleotide binding site such as is found in other proteins adopting a Rossmann fold.	0.0026527
NC_014212.1\|WP_013159377.1\|3053122_3054091_+\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|184521	PRK14122, PRK14122, tRNA pseudouridine synthase B; Provisional.	1.35113e-174
NC_014212.1\|WP_013159369.1\|3046456_3046789_+\|DUF190-domain-containing-protein	gnl\|CDD\|376875	pfam02641, DUF190, Uncharacterized ACR, COG1993.	2.92509e-54
NC_014212.1\|WP_083771732.1\|3059296_3060004_-\|3-keto-5-aminohexanoate-cleavage-protein	gnl\|CDD\|225785	COG3246, COG3246, Uncharacterized conserved protein [Function unknown].	1.17208e-35
NC_014212.1\|WP_013159387.1\|3062414_3062864_+\|signal-peptidase-II	gnl\|CDD\|376504	pfam01252, Peptidase_A8, Signal peptidase (SPase) II.	5.0554e-40
NC_014212.1\|WP_013159378.1\|3054551_3055028_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	9.41362e-35

>NC_014212.1|WP_013159377.1|3053122_3054091_+|tRNA-pseudouridine(55)-synthase-TruB
MALFAVDKPLGITSHDVVDAARRRLGTRRVGHTGTLDPLATGVLILASNSSTKLVPFLSAEDKEYLAWVSFGATTETLDAEGPVTAEAPVRFSKKDLETTLPHFLSLTEQVPPAYSAVKIGGVKAYEAARKGESLELTPRPVKYLEVTLLAFEPAPKTYRIGPSPNGWEITPVKGRQAPGDAGTQRGRLVQLPRALGTYPTAVIRLVVGSGTYVRAFARDLGELLGTKAFLSGLVRTRVGRVGLERCVPLEKIDPEHPLEETQALSFPLVQLSHAEVKRVLEGVPLPIPAQGYVALVDNRRQLIAIAEGDGFKLKIKRVFKK
>NC_014212.1|WP_013159376.1|3052196_3053006_-|enoyl-CoA-hydratase/isomerase-family-protein
MSDWKSAYSRLKFAEPAEGVLEVVLSNPGRLNAADATMHRELAYVWRDIDAEAEISAVLVRGEGGVFSAGGDFAMIEEMIRDYETLVRVWKEARDLVYNILNCSKPVVAAIEGPAVGAGLAVALLSDISVAGKKARILDGHTRLGVAAGDHSAIIWPLLIGLNKSKYYLLLNESMSGEEAERLGLVSLCVDDQAVYAKALELAQRLTQGSATAIRWTKYALNNWLRLAGPTFDASLALEFLGFMGPDAREGLESLKEKRNPKFSKKSPL
>NC_014212.1|WP_013159375.1|3050958_3052068_-|rRNA-pseudouridine-synthase
MRLQQFLARAGVASRRKAEDLIREGRVTINDQIAGIGSSVSESDVVCLDGERVRLPEKKVVIALHKPVGVTTTKSDPHAERTVYQLVPDVPGLHPVGRLDKDSEGLLLLTNDGDLTLKLTHPRYGVRKVYRAWCKHGRVSEADCRRLVEGVALDDGLAQALEAEPTQEGARIVMAEGKKREVRRMLGRLGYPVTRLVRLQVGPIKLGKLNPGEWRYLTPEEIGLLQGQKPLKPRKKEGWAKAKPAKFAQQREESRAIKPPSRTEQGRAGFTVRTKSPGDTPQAGTDRWARWARESDRSAQRSGRWGTSRRPYQGKRTAELEPKGLGSKSTSSTKTPGERTRPASLRKDAATGIKQRSTSAALKRRGKKP
>NC_014212.1|WP_041653671.1|3050399_3050930_-|hypoxanthine-phosphoribosyltransferase
MFQAGDGLVQISEQQIQERIRELGAQITQDYKGKQPHLICVLNGAFIFMADLVRRIDLPVSMDFLALSSYGDDTKTSGEVELVKDLRYPISGKDVIVVEDIVDTGITLNYLMHYLEARQPASVKIAALLSKPTRRRIEVPIHYLGFEIEDAYVYGYGLDRAQYDRNLPFITSIRSE
>NC_014212.1|WP_013159373.1|3049658_3050330_-|queuosine-precursor-transporter
MRAYRYLDFITALFVVVLIVSNIASTKVVLLGPFTFDGGTILFPLAYIFGDVLTEVYGYKRSRRVIWTGFFLLILATLTFGIVNALPTPPDQQSTAQAFSAILGLVPRIVLASLVAYWVGEFVNSYVLAKLKIATQGRWLWTRTLGSTLIAQGLDTGLFLLIAFYGVWDNALLWTVFVSNYVFKVGVEALFTPLTYAVVGFLKRAEREDYYDRDTNFNPFAVR
>NC_014212.1|WP_013159372.1|3047798_3049574_-|VanW-family-protein
MNPPHPPIRAAKTRRKVALAGVLGIAVLLGGIELYFGSRIFPGVMADGVAVGRMTVEEAAAQIAAQGRLTNRSLVAVQAGGRTYQLSAAELGWRADAMATAQAAFRIGREGGLADSLRERWAAWRQGVNVPVSGVVEKAVLYRRLERLNLALKQPPKNAEVEFKNGRFVVTPDTPGRRFNVERAAASFLADPSTATLELPMEEVAASVQASEYEARAAEANALLRPITLNYTQPGGALKTYTLRPEQVAGLMVLKKEGLEANPAAVRKLLRQVAKAYDQEAVNAHYVWGTSSSLPATLAFTVVGEKPGWKLDLKAAEEALVPLLWQPDARTLDLPVVTVEPTLKAADLPEPSQLVLLSSATTTFKGSSAERIHNVRTAASRLDGYIIAPGETFSFNQVVGDIAPETGFKEGLVISGGRTVPGVGGGVCQVSTTTFRALYKTGLPVVERNPHAYRVHWYDPIIGFDAAVYQPYLDLRMKNDTPSPLLLRTYYDPDKVSLTVSVWGLPIGRTVTISDPVILSRTPHPPAKYIEDDSLRPGVRKQVDWAADGYSVRLSRTITDASGTRTEVLSTRYRPWQAVYLVGPSQAHPGR
>NC_014212.1|WP_013159371.1|3047484_3047793_+|hypothetical-protein
MTAEAQAVQIALQAYRDCQELEEREYAEQYDEVKRMEDEAPAPDPCALLFNELVEACIRYVEAGGNRADLDLGEYRSAVYRRMDEFRSVQRWEDEGGSTPPA
>NC_014212.1|WP_013159370.1|3046861_3047458_+|sulfite-oxidase-like-oxidoreductase
MFGNFFKSPKDERGRVPPGQTLTERFPVLTYGPTPSLKPQEVRLKVYGRVETPLELSWDDLMGLPQSDLTADFHCVTRWSKLDVKWRGVRVLDLMEQVRLEPSAKAVLLHCYGGYTTNLLLEDFLRPENLLAHTLYGEPLPRDHGGPLRLIVPHLYAWKSAKWLRGLEFLDREELGFWEVNGYHRRGDPWKEERFSEG
>NC_014212.1|WP_013159369.1|3046456_3046789_+|DUF190-domain-containing-protein
MKLEGEAKLVRIFIGESDRWQGKPLYEAIVLEAKRQGLAGATVFKGVTGFGAHSRIHSAKILQLSEDLPMMIEIVDAEEKVRAFLPALEAMVGEGLVTMERVEVIRYRHR
>NC_014212.1|WP_013159368.1|3046071_3046437_+|fluoride-efflux-transporter-CrcB
MERYLLVMLGGAIGAGLRYGLGAWLQGLAGPSFPWSTFFINLSGSFLIGAVLRRSLEGNLSTEARLFLAVGIFGGYTTFSTFSYETLTLVQQGEWLKAFLYVTGSVVLGFIAVWLAYRLAG
>NC_014212.1|WP_013159378.1|3054551_3055028_-|Lrp/AsnC-family-transcriptional-regulator
MASESQRLLDPINLAILHELQQDARLSYSELGRRVGLSTPAVTERVRRLEDRGIITGYGLRLDLARLGYEITALIEVAAPPTRYNQVVEFARGKLEVRECYFVTGESSFVARVVARSIAHLQELIQQMMVFGSTRTSVVLSTPIIKETFELRAMDDAQ
>NC_014212.1|WP_013159379.1|3055136_3056243_+|alanine-dehydrogenase
MVIGVPKEIKTLENRVALTPGGVTSLVRRGHTVRVQQNAGVGSGISDSEYLAAGAEIVTAEEAWAADLVVKVKEPIAEEYKYLREGLLLFTYLHLAADEALTQALLAGGTIAIAYETVQLEDGSLPLLVPMSEVAGRMAPQVGAAALEKPHGGRGVLLGGVPGVAPASVVILGGGVVGTNAAKIALGMGAQVTILELSKARLQYLDDIFGGRVITLASTEANIAASIRHADLLIGGVLIPGAKAPKLVTRDMLRSMKEGAVIVDVAVDQGGCVETIHPTTHANPTYVVDGVVHYGVANMPGAVPRTSTFALTNQTLPYLIRLAEKGLDALREDPALRKGLNTFAGKCTYKGVAEAFGLPYTPAESVLG
>NC_014212.1|WP_169307870.1|3056413_3057025_+|DUF3108-domain-containing-protein
MPWPAGEKLTYRATWQGMVAGQLQLEAQPLEQGWSFKGRMNPQGVGVLLGYSLELDSQVGADLFITRYRKLLTEPFKGQTRLEVALRDNGLEATLTYPGGAKGGWRSATREALDDLSVIYYIRVHPGAQSVRLVQFPRVIEGRLENLGKNREGLLGYRFVQADTVVEVWYADDPQRTPVRIVYGRDLGRVEASLVATSQSGSH
>NC_014212.1|WP_013159381.1|3057344_3058073_+|alpha/beta-hydrolase
MTARVVVAIVGFLWVAWALPTNRSPQSVAFQAVDRVQVYGTYYPTGDRTRPVVLLFHQSESNRGEYAQIAPRLVELGFNALAIDQRVGGSMWGMRNQTYERLRRIAGYEETLRDLEAALNWVTQSGHTGAVLVWGSSYSSALVFLLVAQHPKIAGILSFSPWEYLWGEDTVRQAAAKVQVPVFITSAKDEAEQARVIFQAVASPNKIQFVPRHDGRHGSPALDGEDREEYWQAVRAFLTQFN
>NC_014212.1|WP_013159382.1|3058160_3059270_-|AI-2E-family-transporter
MRETFRQAWQYLWVRVAVYTLLIVLVLYYLNWALAMARSAIVTVLIAVVFSYITSPIVRWFERRRLSRALGVVVVFVGFLLFVALASVLLANMAGQLAGFLTGLPNLLAPLLDWAQALPGRFGQIELPQPVRDALAQASSSIQTLLQGFTQSLLRLLQALLAQGGNLIGFFSNLVGGIFQLLTALTISIYLLYDLPKIAHTLLKAIPEPYQPMALEVSQKADRAFGSFVRGQVLVATISGTIVAVGLSIVGVPQAASLGFLTFIFNFIPFVGVIISAIPAILLALPLGWLKLALTVGVLYLTNQLEGNVYGPFVMRRAVSIHPVTGIIGILIASSLFGFIGVLFSTPMLAFFKILYVDYYQKSRFYREG
>NC_014212.1|WP_083771732.1|3059296_3060004_-|3-keto-5-aminohexanoate-cleavage-protein
MTLQACLNGARAHPTVPVTPQQIAAEGWRSVEAGVNALHLHPRGAAGKETLQASVCAEVLEAVRAVCPGIVVGLSTGFWIVPDEARRYAQIREWHLLPDYCSVNFSEPGAEELCELLFSRGIGVEAGLANVRDTYRLLERCLRPLIEIETQDLAEALREAEAIEVLLDKALLKVPRLLHGVDATAWPLLELSLQRGYDVRMGLEDTLALPDGRLASGNAELIAQARILAKKAGQI
>NC_014212.1|WP_013159384.1|3060006_3060723_-|M23-family-metallopeptidase
MGLKPGWYILGAALLYALVMTLAWSAERRQVAALRTEVAKARDSVKRGPEGLMLPLIGACLPKDRANLPGAPRKYRQGVNQGFVFTDGSSCVPVVYGTGVVAAGGGEVTKLERDYKEPTLAEFEALLKAVEKGATPAQLDQLRGREIWIRHPDGSATVYAHLSEIAPGLEVGSKVTKGQFIGKVGNSGTPAGVRGSRAGARLLFELWTGTPGESRFFGQGIESPEALLVQAKQRFGLP
>NC_014212.1|WP_013159385.1|3060833_3061130_-|50S-ribosomal-protein-L28
MSRICEISGKRPTVVNSVTRRGKAKADGGVGKKTTGISKRWQYPNLQKVNITVAGQEITFRVATSYVHKVYELAERAKGMQLEGLTAKQIKAKLLQLV
>NC_014212.1|WP_013159386.1|3061215_3062286_-|transposase
MQFTTVGREIWRGARQAQRLAEANASDPEVQERLRKLRLVKALRESKKSWKEIQDLVGISRATYHRWQKALKEKGLAGLKPRSRRPKHLRTKVHWTPGLLIRIETLRKENPTWGRWSIWLTLRKEGFQMSERTVGRILAYLEKHRRIESVAGYLARTQRGKLKRRVNRPYAKRKPRGYEARAPGDLVQVDTLTLTLGPGSMVKHFSAIDLHSRFVLAEVHSRATAKLSEGFLSLLLARAPFPIRAIQVDGGSEFMAEFEEACCALGIALFVLPPRSPKLNGHVERMQRTFKEEFYTRPLPTPLSELQAELDTYLDYYNRRRPHMALGGLAPLEFLAKMQEESVPQRVSNVLTDYKT
>NC_014212.1|WP_013159387.1|3062414_3062864_+|signal-peptidase-II
MPLILVPLLLCLDQAVKIWAVAHLAPGVPHPFIPLLNLTLIYNTGAAFGLFPGGARILVVVSVVVGFGILYYLSRHRLPLLQQVAFSLIAAGALGNAIDRIGRGSVVDYLDTTGTGWGPFDNFPIFNLADACVVVGVILLLLPIRRRKW

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	108000-108020	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	1319924-1319944	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2238896-2238916	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2238935-2238955	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2238974-2238994	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2239013-2239033	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2855129-2855149	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2855168-2855188	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2855207-2855227	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	3135972-3135992	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	53068-53088	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	53107-53127	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	53146-53166	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	53185-53205	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	1434634-1434654	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	1434673-1434693	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	1784138-1784158	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2296277-2296297	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2296316-2296336	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2296355-2296375	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2296394-2296414	0	1.0
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	810048-810068	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	810087-810107	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2055839-2055859	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2065314-2065334	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2065353-2065373	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2065392-2065412	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2065431-2065451	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2065470-2065490	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2065509-2065529	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	546199-546219	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	1228968-1228988	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2101557-2101577	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2101596-2101616	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2101635-2101655	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2432592-2432612	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2432631-2432651	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2574613-2574633	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2574652-2574672	1	0.952
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	299001-299021	2	0.905
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014212.1	2916583-2916603	2	0.905
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_014213.1	128675-128695	2	0.905
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	108000-108020	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	1319924-1319944	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2238896-2238916	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2238935-2238955	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2238974-2238994	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2239013-2239033	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2855129-2855149	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2855168-2855188	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2855207-2855227	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	3135972-3135992	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	53068-53088	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	53107-53127	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	53146-53166	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	53185-53205	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	1434634-1434654	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	1434673-1434693	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	1784138-1784158	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2296277-2296297	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2296316-2296336	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2296355-2296375	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2296394-2296414	0	1.0
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	810048-810068	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	810087-810107	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2055839-2055859	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2065314-2065334	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2065353-2065373	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2065392-2065412	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2065431-2065451	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2065470-2065490	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2065509-2065529	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	546199-546219	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	1228968-1228988	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2101557-2101577	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2101596-2101616	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2101635-2101655	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2432592-2432612	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2432631-2432651	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2574613-2574633	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2574652-2574672	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	299001-299021	2	0.905
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014212.1	2916583-2916603	2	0.905
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_014213.1	128675-128695	2	0.905
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	108000-108020	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	1319924-1319944	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2238896-2238916	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2238935-2238955	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2238974-2238994	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2239013-2239033	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2855129-2855149	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2855168-2855188	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2855207-2855227	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	3135972-3135992	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	53068-53088	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	53107-53127	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	53146-53166	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	53185-53205	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	1434634-1434654	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	1434673-1434693	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	1784138-1784158	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2296277-2296297	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2296316-2296336	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2296355-2296375	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2296394-2296414	0	1.0
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	810048-810068	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	810087-810107	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2055839-2055859	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2065314-2065334	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2065353-2065373	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2065392-2065412	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2065431-2065451	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2065470-2065490	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2065509-2065529	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	546199-546219	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	1228968-1228988	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2101557-2101577	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2101596-2101616	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2101635-2101655	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2432592-2432612	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2432631-2432651	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2574613-2574633	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2574652-2574672	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	299001-299021	2	0.905
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014212.1	2916583-2916603	2	0.905
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_014213.1	128675-128695	2	0.905
NC_014212_6	6.4\|3054386\|28\|NC_014212\|CRT	3054386-3054413	28	NC_014212.1	129486-129513	0	1.0
NC_014212_6	6.4\|3054386\|28\|NC_014212\|CRT	3054386-3054413	28	NC_014212.1	1460135-1460162	0	1.0
NC_014212_6	6.5\|3054432\|21\|NC_014212\|CRT	3054432-3054452	21	NC_014212.1	356421-356441	0	1.0
NC_014212_6	6.5\|3054432\|21\|NC_014212\|CRT	3054432-3054452	21	NC_014212.1	399291-399311	0	1.0
NC_014212_6	6.5\|3054432\|21\|NC_014212\|CRT	3054432-3054452	21	NC_014212.1	399330-399350	0	1.0
NC_014212_6	6.5\|3054432\|21\|NC_014212\|CRT	3054432-3054452	21	NC_014212.1	129532-129552	0	1.0
NC_014212_6	6.5\|3054432\|21\|NC_014212\|CRT	3054432-3054452	21	NC_014212.1	3054471-3054491	0	1.0

1. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 108000-108020, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

2. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 1319924-1319944, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

3. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2238896-2238916, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

4. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2238935-2238955, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

5. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2238974-2238994, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

6. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2239013-2239033, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

7. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2855129-2855149, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

8. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2855168-2855188, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

9. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2855207-2855227, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

10. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 3135972-3135992, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

11. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 53068-53088, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

12. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 53107-53127, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

13. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 53146-53166, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

14. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 53185-53205, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

15. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 1434634-1434654, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

16. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 1434673-1434693, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

17. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 1784138-1784158, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

18. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2296277-2296297, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

19. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2296316-2296336, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

20. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2296355-2296375, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

21. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2296394-2296414, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

22. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 810048-810068, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

23. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 810087-810107, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

24. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2055839-2055859, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccaatggcc	Protospacer
**************.******

25. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2065314-2065334, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

26. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2065353-2065373, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

27. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2065392-2065412, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

28. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2065431-2065451, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

29. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2065470-2065490, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

30. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2065509-2065529, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

31. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 546199-546219, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

32. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 1228968-1228988, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

33. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2101557-2101577, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

34. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2101596-2101616, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

35. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2101635-2101655, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

36. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2432592-2432612, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

37. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2432631-2432651, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

38. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2574613-2574633, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

39. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2574652-2574672, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

40. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 299001-299021, mismatch: 2, identity: 0.905

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggagccgatggcc	Protospacer
**.*******.**********

41. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 2916583-2916603, mismatch: 2, identity: 0.905

gccagccgggggccgatggcc	CRISPR spacer
gccagccggtgggcgatggcc	Protospacer
********* ** ********

42. spacer 6.1|3054269|21|NC_014212|CRT matches to position: 128675-128695, mismatch: 2, identity: 0.905

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggagccgatagcc	Protospacer
**********.******.***

43. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 108000-108020, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

44. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 1319924-1319944, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

45. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2238896-2238916, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

46. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2238935-2238955, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

47. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2238974-2238994, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

48. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2239013-2239033, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

49. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2855129-2855149, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

50. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2855168-2855188, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

51. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2855207-2855227, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

52. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 3135972-3135992, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

53. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 53068-53088, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

54. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 53107-53127, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

55. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 53146-53166, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

56. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 53185-53205, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

57. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 1434634-1434654, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

58. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 1434673-1434693, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

59. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 1784138-1784158, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

60. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2296277-2296297, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

61. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2296316-2296336, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

62. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2296355-2296375, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

63. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2296394-2296414, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

64. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 810048-810068, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

65. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 810087-810107, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

66. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2055839-2055859, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccaatggcc	Protospacer
**************.******

67. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2065314-2065334, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

68. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2065353-2065373, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

69. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2065392-2065412, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

70. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2065431-2065451, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

71. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2065470-2065490, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

72. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2065509-2065529, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

73. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 546199-546219, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

74. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 1228968-1228988, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

75. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2101557-2101577, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

76. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2101596-2101616, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

77. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2101635-2101655, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

78. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2432592-2432612, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

79. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2432631-2432651, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

80. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2574613-2574633, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

81. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2574652-2574672, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

82. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 299001-299021, mismatch: 2, identity: 0.905

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggagccgatggcc	Protospacer
**.*******.**********

83. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 2916583-2916603, mismatch: 2, identity: 0.905

gccagccgggggccgatggcc	CRISPR spacer
gccagccggtgggcgatggcc	Protospacer
********* ** ********

84. spacer 6.2|3054308|21|NC_014212|CRT matches to position: 128675-128695, mismatch: 2, identity: 0.905

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggagccgatagcc	Protospacer
**********.******.***

85. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 108000-108020, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

86. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 1319924-1319944, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

87. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2238896-2238916, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

88. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2238935-2238955, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

89. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2238974-2238994, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

90. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2239013-2239033, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

91. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2855129-2855149, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

92. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2855168-2855188, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

93. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2855207-2855227, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

94. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 3135972-3135992, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

95. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 53068-53088, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

96. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 53107-53127, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

97. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 53146-53166, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

98. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 53185-53205, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

99. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 1434634-1434654, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

100. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 1434673-1434693, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

101. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 1784138-1784158, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

102. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2296277-2296297, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

103. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2296316-2296336, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

104. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2296355-2296375, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

105. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2296394-2296414, mismatch: 0, identity: 1.0

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccgatggcc	Protospacer
*********************

106. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 810048-810068, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

107. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 810087-810107, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

108. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2055839-2055859, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggggccaatggcc	Protospacer
**************.******

109. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2065314-2065334, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

110. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2065353-2065373, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

111. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2065392-2065412, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

112. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2065431-2065451, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

113. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2065470-2065490, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

114. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2065509-2065529, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

115. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 546199-546219, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

116. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 1228968-1228988, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

117. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2101557-2101577, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

118. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2101596-2101616, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

119. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2101635-2101655, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

120. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2432592-2432612, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

121. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2432631-2432651, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

122. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2574613-2574633, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

123. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2574652-2574672, mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggggccgatggcc	Protospacer
**.******************

124. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 299001-299021, mismatch: 2, identity: 0.905

gccagccgggggccgatggcc	CRISPR spacer
gctagccgggagccgatggcc	Protospacer
**.*******.**********

125. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 2916583-2916603, mismatch: 2, identity: 0.905

gccagccgggggccgatggcc	CRISPR spacer
gccagccggtgggcgatggcc	Protospacer
********* ** ********

126. spacer 6.3|3054347|21|NC_014212|CRT matches to position: 128675-128695, mismatch: 2, identity: 0.905

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggagccgatagcc	Protospacer
**********.******.***

127. spacer 6.4|3054386|28|NC_014212|CRT matches to position: 129486-129513, mismatch: 0, identity: 1.0

gccagcccaggttaccggcaagcactag	CRISPR spacer
gccagcccaggttaccggcaagcactag	Protospacer
****************************

128. spacer 6.4|3054386|28|NC_014212|CRT matches to position: 1460135-1460162, mismatch: 0, identity: 1.0

gccagcccaggttaccggcaagcactag	CRISPR spacer
gccagcccaggttaccggcaagcactag	Protospacer
****************************

129. spacer 6.5|3054432|21|NC_014212|CRT matches to position: 356421-356441, mismatch: 0, identity: 1.0

catcgccgggtcgctatgcga	CRISPR spacer
catcgccgggtcgctatgcga	Protospacer
*********************

130. spacer 6.5|3054432|21|NC_014212|CRT matches to position: 399291-399311, mismatch: 0, identity: 1.0

catcgccgggtcgctatgcga	CRISPR spacer
catcgccgggtcgctatgcga	Protospacer
*********************

131. spacer 6.5|3054432|21|NC_014212|CRT matches to position: 399330-399350, mismatch: 0, identity: 1.0

catcgccgggtcgctatgcga	CRISPR spacer
catcgccgggtcgctatgcga	Protospacer
*********************

132. spacer 6.5|3054432|21|NC_014212|CRT matches to position: 129532-129552, mismatch: 0, identity: 1.0

catcgccgggtcgctatgcga	CRISPR spacer
catcgccgggtcgctatgcga	Protospacer
*********************

133. spacer 6.5|3054432|21|NC_014212|CRT matches to position: 3054471-3054491, mismatch: 0, identity: 1.0

catcgccgggtcgctatgcga	CRISPR spacer
catcgccgggtcgctatgcga	Protospacer
*********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014212_6	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	720896-720916	1	0.952
NC_014212_6	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	720896-720916	1	0.952
NC_014212_6	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	720896-720916	1	0.952
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	MN234172	Mycobacterium phage ThulaThula, complete genome	37849-37880	6	0.812
NC_014212_6	6.4\|3054386\|28\|NC_014212\|CRT	3054386-3054413	28	NZ_LN997849	Magnetospirillum sp. XM-1 isolate XM1 plasmid II, complete sequence	63889-63916	7	0.75
NC_014212_1	1.1\|698317\|42\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	698317-698358	42	NZ_CP044080	Paracoccus yeei strain FDAARGOS_643 plasmid unnamed3, complete sequence	22174-22215	8	0.81
NC_014212_1	1.1\|698317\|42\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	698317-698358	42	NZ_CP031082	Paracoccus yeei strain CCUG 32053 plasmid pYEE4, complete sequence	31269-31310	8	0.81
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	NZ_CP020332	Martelella mediterranea DSM 17316 strain MACL11 plasmid pMM259, complete sequence	50822-50853	8	0.75
NC_014212_2	2.4\|1221264\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221264-1221295	32	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1338852-1338883	8	0.75
NC_014212_6	6.4\|3054386\|28\|NC_014212\|CRT	3054386-3054413	28	NC_022267	Salmonella enterica subsp. enterica serovar Enteritidis strain S1400/94 plasmid pS1400_89, complete sequence	7695-7722	8	0.714
NC_014212_6	6.4\|3054386\|28\|NC_014212\|CRT	3054386-3054413	28	NZ_CP054369	Escherichia coli strain SCU-115 plasmid pSCU-115-1, complete sequence	77321-77348	8	0.714
NC_014212_6	6.4\|3054386\|28\|NC_014212\|CRT	3054386-3054413	28	NZ_CP015161	Escherichia coli strain Eco889 plasmid pECO-93a, complete sequence	54934-54961	8	0.714
NC_014212_6	6.4\|3054386\|28\|NC_014212\|CRT	3054386-3054413	28	NZ_CP050647	Escherichia coli strain PapM-36-2 plasmid pIncFIB, complete sequence	27814-27841	8	0.714
NC_014212_6	6.4\|3054386\|28\|NC_014212\|CRT	3054386-3054413	28	NZ_CP010126	Escherichia coli strain C8 plasmid A, complete genome	21936-21963	8	0.714
NC_014212_6	6.4\|3054386\|28\|NC_014212\|CRT	3054386-3054413	28	NZ_CP031323	Escherichia coli strain ST2350 isolate Es_ST2350_SE1_NDM_03_2018 plasmid pEsST2350_SE_2, complete sequence	75889-75916	8	0.714
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	NZ_LR594660	Variovorax sp. PBL-H6 plasmid 2	117386-117417	9	0.719
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	NZ_LR594667	Variovorax sp. SRS16 plasmid 2	682985-683016	9	0.719
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	NZ_LR134451	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence	230917-230948	9	0.719
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	NZ_LR594690	Variovorax sp. WDL1 plasmid 2	697376-697407	9	0.719
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	NZ_LR594672	Variovorax sp. PBL-E5 plasmid 2	683119-683150	9	0.719
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	NC_017767	Thermus thermophilus HB8 plasmid pVV8, complete sequence	64173-64204	9	0.719
NC_014212_2	2.4\|1221264\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221264-1221295	32	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1369016-1369047	9	0.719
NC_014212_2	2.4\|1221264\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221264-1221295	32	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1025865-1025896	9	0.719
NC_014212_2	2.4\|1221264\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221264-1221295	32	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	527356-527387	9	0.719
NC_014212_2	2.4\|1221264\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221264-1221295	32	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1605030-1605061	9	0.719
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	858-889	10	0.688
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	53918-53949	10	0.688
NC_014212_2	2.1\|1221082\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221082-1221113	32	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	1102556-1102587	10	0.688
NC_014212_2	2.2\|1221143\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221143-1221174	32	NC_047948	Staphylococcus phage phiSA_BS2, complete genome	81488-81519	10	0.688
NC_014212_2	2.2\|1221143\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221143-1221174	32	MH078572	Staphylococcus phage phiSA_BS1, complete genome	36341-36372	10	0.688
NC_014212_2	2.10\|1221632\|32\|NC_014212\|PILER-CR,CRISPRCasFinder,CRT	1221632-1221663	32	MK373770	Escherichia phage vB_EcoP_WFI101126, complete genome	13170-13201	10	0.688

1. spacer 6.1|3054269|21|NC_014212|CRT matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggtgccgatggcc	Protospacer
********** **********

2. spacer 6.2|3054308|21|NC_014212|CRT matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggtgccgatggcc	Protospacer
********** **********

3. spacer 6.3|3054347|21|NC_014212|CRT matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 1, identity: 0.952

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggtgccgatggcc	Protospacer
********** **********

4. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to MN234172 (Mycobacterium phage ThulaThula, complete genome) position: , mismatch: 6, identity: 0.812

atcaaacg-ctcctcggcgaggctcaggcgcag	CRISPR spacer
-tcgatcgcctcctcggcgaggtccaggcgcac	Protospacer
 **.* ** *************..********

5. spacer 6.4|3054386|28|NC_014212|CRT matches to NZ_LN997849 (Magnetospirillum sp. XM-1 isolate XM1 plasmid II, complete sequence) position: , mismatch: 7, identity: 0.75

gccagcccaggttaccggcaagcactag	CRISPR spacer
agaggcccaggatatcggcaagcactac	Protospacer
.  .******* **.************

6. spacer 1.1|698317|42|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP044080 (Paracoccus yeei strain FDAARGOS_643 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.81

ccgcttcggccagggccagggccgcccccgcgcccatcacca	CRISPR spacer
ccgccccggccagggccagggccgcccccgccgcccccgccg	Protospacer
****..*************************  ** .*.**.

7. spacer 1.1|698317|42|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031082 (Paracoccus yeei strain CCUG 32053 plasmid pYEE4, complete sequence) position: , mismatch: 8, identity: 0.81

ccgcttcggccagggccagggccgcccccgcgcccatcacca	CRISPR spacer
ccgccccggccagggccagggccgcccccgccgcccccgccg	Protospacer
****..*************************  ** .*.**.

8. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020332 (Martelella mediterranea DSM 17316 strain MACL11 plasmid pMM259, complete sequence) position: , mismatch: 8, identity: 0.75

atcaaacgctcctcggcgaggctcaggcgcag	CRISPR spacer
tgcgaccgctcttcggcgatgctcaggcgctc	Protospacer
  *.* *****.******* **********

9. spacer 2.4|1221264|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.75

taccacacccccctcagcctgaaccggtagac	CRISPR spacer
agctacacccccttcaccctgaaccggttgga	Protospacer
 .*.********.*** *********** *.

10. spacer 6.4|3054386|28|NC_014212|CRT matches to NC_022267 (Salmonella enterica subsp. enterica serovar Enteritidis strain S1400/94 plasmid pS1400_89, complete sequence) position: , mismatch: 8, identity: 0.714

gccagcccaggttaccggcaagcactag	CRISPR spacer
cccagcccaggttgccggcaagtgtggc	Protospacer
 ************.********... .

11. spacer 6.4|3054386|28|NC_014212|CRT matches to NZ_CP054369 (Escherichia coli strain SCU-115 plasmid pSCU-115-1, complete sequence) position: , mismatch: 8, identity: 0.714

gccagcccaggttaccggcaagcactag	CRISPR spacer
cccagcccaggttgccggcaagtgtggc	Protospacer
 ************.********... .

12. spacer 6.4|3054386|28|NC_014212|CRT matches to NZ_CP015161 (Escherichia coli strain Eco889 plasmid pECO-93a, complete sequence) position: , mismatch: 8, identity: 0.714

gccagcccaggttaccggcaagcactag	CRISPR spacer
cccagcccaggttgccggcaagtgtggc	Protospacer
 ************.********... .

13. spacer 6.4|3054386|28|NC_014212|CRT matches to NZ_CP050647 (Escherichia coli strain PapM-36-2 plasmid pIncFIB, complete sequence) position: , mismatch: 8, identity: 0.714

gccagcccaggttaccggcaagcactag	CRISPR spacer
cccagcccaggttgccggcaagagtggc	Protospacer
 ************.******** .. .

14. spacer 6.4|3054386|28|NC_014212|CRT matches to NZ_CP010126 (Escherichia coli strain C8 plasmid A, complete genome) position: , mismatch: 8, identity: 0.714

gccagcccaggttaccggcaagcactag	CRISPR spacer
cccagcccaggttgccggcaagagtggc	Protospacer
 ************.******** .. .

15. spacer 6.4|3054386|28|NC_014212|CRT matches to NZ_CP031323 (Escherichia coli strain ST2350 isolate Es_ST2350_SE1_NDM_03_2018 plasmid pEsST2350_SE_2, complete sequence) position: , mismatch: 8, identity: 0.714

gccagcccaggttaccggcaagcactag	CRISPR spacer
cccagcccaggttgccggcaagagtggc	Protospacer
 ************.******** .. .

16. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR594660 (Variovorax sp. PBL-H6 plasmid 2) position: , mismatch: 9, identity: 0.719

atcaaacgctcctcggcgaggctcaggcgcag	CRISPR spacer
cacgtcgggtcctcggcgagtttcaggcgcag	Protospacer
  *.   * *********** .**********

17. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR594667 (Variovorax sp. SRS16 plasmid 2) position: , mismatch: 9, identity: 0.719

atcaaacgctcctcggcgaggctcaggcgcag	CRISPR spacer
cacgtcgggtcctcggcgagtttcaggcgcag	Protospacer
  *.   * *********** .**********

18. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134451 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence) position: , mismatch: 9, identity: 0.719

atcaaacgctcctcggcgaggctcaggcgcag	CRISPR spacer
gtgagcacgtcgtcggcgagactcaggcgcag	Protospacer
.* *.    ** ********.***********

19. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR594690 (Variovorax sp. WDL1 plasmid 2) position: , mismatch: 9, identity: 0.719

atcaaacgctcctcggcgaggctcaggcgcag	CRISPR spacer
cacgtcgggtcctcggcgagtttcaggcgcag	Protospacer
  *.   * *********** .**********

20. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR594672 (Variovorax sp. PBL-E5 plasmid 2) position: , mismatch: 9, identity: 0.719

atcaaacgctcctcggcgaggctcaggcgcag	CRISPR spacer
cacgtcgggtcctcggcgagtttcaggcgcag	Protospacer
  *.   * *********** .**********

21. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NC_017767 (Thermus thermophilus HB8 plasmid pVV8, complete sequence) position: , mismatch: 9, identity: 0.719

atcaaacgctcctcggcgaggctcaggcgcag	CRISPR spacer
ctcagaagctcctcggcgaggctctcctggac	Protospacer
 ***.* *****************   .* *

22. spacer 2.4|1221264|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.719

taccacacccccctcagcctgaaccggtagac	CRISPR spacer
agctacacccccttcaccctgaaccggctgga	Protospacer
 .*.********.*** **********. *.

23. spacer 2.4|1221264|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 9, identity: 0.719

taccacacccccctcagcctgaaccggtagac	CRISPR spacer
agctacacccccttcaccctgaaccggctgga	Protospacer
 .*.********.*** **********. *.

24. spacer 2.4|1221264|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.719

taccacacccccctcagcctgaaccggtagac	CRISPR spacer
agctacacccccttcaccctgaaccggctgga	Protospacer
 .*.********.*** **********. *.

25. spacer 2.4|1221264|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 9, identity: 0.719

taccacacccccctcagcctgaaccggtagac	CRISPR spacer
agctacacccccttcaccctgaaccggctgga	Protospacer
 .*.********.*** **********. *.

26. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 10, identity: 0.688

atcaaacgctcctcggcgaggctcaggcgcag	CRISPR spacer
gcagcgcgctcctcggcgaggaccaggcggtg	Protospacer
.. . .*************** .******  *

27. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 10, identity: 0.688

atcaaacgctcctcggcgaggctcaggcgcag	CRISPR spacer
gcagcgcgctcctcggcgaggaccaggcggtg	Protospacer
.. . .*************** .******  *

28. spacer 2.1|1221082|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 10, identity: 0.688

atcaaacgctcctcggcgaggctcaggcgcag	CRISPR spacer
gcagcgcgctcctcggcgaggaccaggcggtg	Protospacer
.. . .*************** .******  *

29. spacer 2.2|1221143|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to NC_047948 (Staphylococcus phage phiSA_BS2, complete genome) position: , mismatch: 10, identity: 0.688

gagatggaatgaccaaggaaaatataccacaa	CRISPR spacer
ttttactaatgaccaaggacaatatactacac	Protospacer
       ************ *******.***

30. spacer 2.2|1221143|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to MH078572 (Staphylococcus phage phiSA_BS1, complete genome) position: , mismatch: 10, identity: 0.688

gagatggaatgaccaaggaaaatataccacaa	CRISPR spacer
ttttactaatgaccaaggacaatatactacac	Protospacer
       ************ *******.***

31. spacer 2.10|1221632|32|NC_014212|PILER-CR,CRISPRCasFinder,CRT matches to MK373770 (Escherichia phage vB_EcoP_WFI101126, complete genome) position: , mismatch: 10, identity: 0.688

aaattcattagcagtagaacttaatcctgaac	CRISPR spacer
gaattcattagctgtagcacttaagtactact	Protospacer
.*********** **** ****** . . * .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

522490 : 554042

Erysipelothrix_phage(33.33%)

integrase,transposase

attL 514315:514329|attR 560131:560145

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
514315:514329	attL	NA	NA	NA	NA
WP_013157066.1\|522490_523540_-\|transposase	transposase	NA	NA	NA	NA
WP_013157067.1\|523663_523918_+	hypothetical protein	NA	NA	NA	NA
WP_013012838.1\|523975_524476_-	RES domain-containing protein	NA	NA	NA	NA
WP_015586363.1\|524472_524871_-	DUF2384 domain-containing protein	NA	NA	NA	NA
WP_013012840.1\|524903_525137_-	hypothetical protein	NA	NA	NA	NA
WP_013012841.1\|525560_526961_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_013157068.1\|526957_527419_+	hypothetical protein	NA	NA	NA	NA
WP_013012843.1\|527465_528122_+	hypothetical protein	NA	NA	NA	NA
WP_013012844.1\|528185_529172_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	2.7e-16	27.4
WP_013012845.1\|529174_529966_+	ABC-2 family transporter protein	NA	NA	NA	NA
WP_013012846.1\|529966_530764_+	ABC-2 family transporter protein	NA	NA	NA	NA
WP_013012847.1\|530799_531774_+	aldo/keto reductase	NA	NA	NA	NA
WP_013012848.1\|531807_532635_+	hypothetical protein	NA	NA	NA	NA
WP_013012849.1\|532653_533148_+	hypothetical protein	NA	NA	NA	NA
WP_157413565.1\|533601_534399_+	cytochrome P450	NA	NA	NA	NA
WP_015586368.1\|534524_534950_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_018465403.1\|535167_535578_+\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_156941926.1\|535630_535768_+	hypothetical protein	NA	NA	NA	NA
WP_169307844.1\|535937_536732_+\|transposase	transposase	NA	NA	NA	NA
WP_013012852.1\|537050_537578_+	hypothetical protein	E5E454	Acinetobacter_phage	7.7e-34	45.9
WP_013157070.1\|537615_537837_+	hypothetical protein	NA	NA	NA	NA
WP_013157071.1\|537859_538081_+	hypothetical protein	NA	NA	NA	NA
WP_013157072.1\|538077_538524_+	PIN domain-containing protein	NA	NA	NA	NA
WP_013157073.1\|538633_539656_+	hypothetical protein	NA	NA	NA	NA
WP_013157074.1\|539926_540106_+	hypothetical protein	NA	NA	NA	NA
WP_013157075.1\|540129_540540_+	hypothetical protein	NA	NA	NA	NA
WP_013157076.1\|540515_540773_+	hypothetical protein	NA	NA	NA	NA
WP_013157077.1\|540848_541481_+	hypothetical protein	NA	NA	NA	NA
WP_169307845.1\|541471_541618_-	hypothetical protein	NA	NA	NA	NA
WP_013157078.1\|541616_541889_+	hypothetical protein	NA	NA	NA	NA
WP_013157079.1\|541977_542433_+	hypothetical protein	NA	NA	NA	NA
WP_013157080.1\|542432_542720_+	hypothetical protein	NA	NA	NA	NA
WP_013157081.1\|542716_542926_+	hypothetical protein	NA	NA	NA	NA
WP_013157082.1\|542976_543159_+	hypothetical protein	NA	NA	NA	NA
WP_013157083.1\|543127_543358_+	hypothetical protein	NA	NA	NA	NA
WP_013157084.1\|543326_544022_+	hypothetical protein	NA	NA	NA	NA
WP_013157085.1\|543994_544759_+	ATP-binding protein	NA	NA	NA	NA
WP_013157086.1\|544816_545944_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1P8DJG9	Virus_Rctr71	1.2e-79	46.2
WP_013157087.1\|546054_546372_+	SWIM zinc finger family protein	NA	NA	NA	NA
WP_013157088.1\|546432_546942_+	RAD52/22 double-strand break repair protein	A0A191ZDG3	Pseudoalteromonas_virus	6.3e-17	42.4
WP_013157089.1\|547001_549677_-	DEAD/DEAH box helicase family protein	A0A2K5B256	Erysipelothrix_phage	1.6e-156	37.1
WP_013157090.1\|549720_551610_-	site-specific DNA-methyltransferase	A0A2K5B2C1	Erysipelothrix_phage	4.4e-116	38.5
WP_013157091.1\|553286_554042_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
560131:560145	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1629526 : 1747702

104

Mycobacterium_phage(18.75%)

protease,transposase,integrase,tRNA

attL 1702141:1702156|attR 1750722:1750737

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013158078.1\|1629526_1629970_+\|transposase	transposase	NA	NA	NA	NA
WP_148225949.1\|1630198_1632406_-	diguanylate cyclase	G3MA91	Bacillus_virus	4.1e-12	31.9
WP_148226044.1\|1632557_1632857_-	EAL domain-containing protein	NA	NA	NA	NA
WP_083771650.1\|1634062_1634671_+\|transposase	transposase	NA	NA	NA	NA
WP_013158081.1\|1635016_1636252_-	imidazolonepropionase	NA	NA	NA	NA
WP_013158082.1\|1636348_1637992_-	urocanate hydratase	NA	NA	NA	NA
WP_013158083.1\|1637988_1638684_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_013158084.1\|1638782_1640303_+	histidine ammonia-lyase	A0A1V0S940	Catovirus	1.2e-92	41.8
WP_013158085.1\|1640299_1641025_-	DUF58 domain-containing protein	NA	NA	NA	NA
WP_049777888.1\|1641098_1641956_-	AAA family ATPase	NA	NA	NA	NA
WP_013158087.1\|1642202_1642397_-	hypothetical protein	NA	NA	NA	NA
WP_013158088.1\|1642414_1643260_-	hypothetical protein	NA	NA	NA	NA
WP_013158089.1\|1643375_1644350_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	4.4e-67	46.7
WP_013158090.1\|1644461_1647458_+	preprotein translocase subunit SecA	NA	NA	NA	NA
WP_013158091.1\|1647745_1648495_+	metallophosphoesterase	NA	NA	NA	NA
WP_013158092.1\|1648491_1649229_-	YebC/PmpR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_013158093.1\|1649292_1650492_+	serine hydrolase	NA	NA	NA	NA
WP_013158094.1\|1650510_1651500_+	S-methyl-5-thioribose-1-phosphate isomerase	NA	NA	NA	NA
WP_013158095.1\|1651507_1652128_+	ComF family protein	NA	NA	NA	NA
WP_041653294.1\|1652401_1652800_+	hypothetical protein	NA	NA	NA	NA
WP_041653296.1\|1652820_1653708_-	riboflavin biosynthesis protein RibF	NA	NA	NA	NA
WP_013158098.1\|1653697_1654189_-	NUDIX hydrolase	NA	NA	NA	NA
WP_013158099.1\|1654319_1655753_+	amidohydrolase	NA	NA	NA	NA
WP_013158100.1\|1655806_1658485_+	phosphoenolpyruvate carboxylase	NA	NA	NA	NA
WP_013158101.1\|1658597_1659185_+	NYN domain-containing protein	NA	NA	NA	NA
WP_083771659.1\|1659199_1660267_-	serine/threonine protein kinase	M1I231	Acanthocystis_turfacea_Chlorella_virus	2.0e-12	35.3
WP_041652451.1\|1660154_1660892_+	patatin-like phospholipase family protein	A0A2H4UUE4	Bodo_saltans_virus	5.7e-11	27.7
WP_041652453.1\|1660967_1661828_+	signal peptidase I	NA	NA	NA	NA
WP_013158105.1\|1661945_1662494_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_013158106.1\|1662534_1663791_+\|protease	ATP-dependent protease ATP-binding subunit HslU	A0A191ZC11	Erwinia_phage	1.0e-36	28.7
WP_169307852.1\|1663852_1664920_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_013158108.1\|1664981_1665926_+	hypothetical protein	NA	NA	NA	NA
WP_041653303.1\|1666086_1667835_+	ATP-binding protein	A0A139ZPI2	Marinitoga_camini_virus	4.7e-27	24.8
WP_013158110.1\|1668003_1668558_-	hypothetical protein	NA	NA	NA	NA
WP_148225951.1\|1668632_1669208_-	hypothetical protein	NA	NA	NA	NA
WP_049777889.1\|1669214_1670567_-	hypothetical protein	NA	NA	NA	NA
WP_013158113.1\|1670904_1671396_-	crossover junction endodeoxyribonuclease RuvC	NA	NA	NA	NA
WP_013158114.1\|1671473_1672538_-	cell division protein FtsZ	NA	NA	NA	NA
WP_013158115.1\|1672552_1673794_-	cell division protein FtsA	NA	NA	NA	NA
WP_041653308.1\|1673790_1674411_-	FtsQ-type POTRA domain-containing protein	NA	NA	NA	NA
WP_013158117.1\|1674511_1675336_-	UDP-N-acetylmuramate dehydrogenase	NA	NA	NA	NA
WP_049777802.1\|1675367_1676690_-	UDP-N-acetylmuramate--L-alanine ligase	NA	NA	NA	NA
WP_013158119.1\|1676755_1677829_-	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	NA	NA	NA	NA
WP_049777803.1\|1677825_1678917_-	FtsW/RodA/SpoVE family cell cycle protein	NA	NA	NA	NA
WP_013158121.1\|1678913_1680185_-	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	NA	NA	NA	NA
WP_041653314.1\|1680181_1681045_-	phospho-N-acetylmuramoyl-pentapeptide- transferase	NA	NA	NA	NA
WP_013158123.1\|1681047_1681866_-	hypothetical protein	NA	NA	NA	NA
WP_041653317.1\|1681855_1683139_-	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	NA	NA	NA	NA
WP_013158125.1\|1683155_1684526_-	penicillin-binding protein 2	NA	NA	NA	NA
WP_041653320.1\|1684522_1684783_-	hypothetical protein	NA	NA	NA	NA
WP_013158127.1\|1684797_1685682_-	16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH	NA	NA	NA	NA
WP_013158128.1\|1685683_1686118_-	division/cell wall cluster transcriptional repressor MraZ	NA	NA	NA	NA
WP_041652885.1\|1686533_1686707_-\|transposase	transposase	NA	NA	NA	NA
WP_148226000.1\|1686693_1686873_-	hypothetical protein	NA	NA	NA	NA
WP_041652458.1\|1686953_1687385_-\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	2.4e-09	34.9
WP_169307853.1\|1687503_1687779_+\|transposase	transposase	NA	NA	NA	NA
WP_013158129.1\|1688129_1689407_-	NADP-dependent isocitrate dehydrogenase	Q77Z09	Phage_21	1.4e-09	62.1
WP_083771717.1\|1689516_1690017_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_013158131.1\|1690297_1690585_-	Lrp/AsnC ligand binding domain-containing protein	NA	NA	NA	NA
WP_013158132.1\|1690638_1691358_-	metallophosphoesterase	NA	NA	NA	NA
WP_169307887.1\|1691537_1693676_-	hypothetical protein	NA	NA	NA	NA
WP_013158134.1\|1694715_1697481_-	DUF11 domain-containing protein	NA	NA	NA	NA
WP_013158135.1\|1697541_1698618_+\|transposase	transposase	NA	NA	NA	NA
WP_013158136.1\|1698599_1698848_-	hypothetical protein	NA	NA	NA	NA
WP_013156564.1\|1698911_1699943_-\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA
WP_013158138.1\|1700622_1701888_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	9.7e-67	38.3
WP_083771660.1\|1701824_1702283_+	RecX family transcriptional regulator	NA	NA	NA	NA
1702141:1702156	attL	NA	NA	NA	NA
WP_013158140.1\|1703478_1703916_+	SRPBCC family protein	NA	NA	NA	NA
WP_013158141.1\|1704057_1705503_+\|tRNA	cysteine--tRNA ligase	A0A1V0SAQ2	Catovirus	1.1e-42	26.8
WP_013158142.1\|1705484_1705643_+	hypothetical protein	NA	NA	NA	NA
WP_148226045.1\|1705809_1706472_-	zinc metallopeptidase	NA	NA	NA	NA
WP_013158144.1\|1706631_1706904_-	stage V sporulation protein S	NA	NA	NA	NA
WP_013158145.1\|1706941_1708036_-\|transposase	transposase	NA	NA	NA	NA
WP_041653328.1\|1708468_1712986_+	glutamate synthase	NA	NA	NA	NA
WP_041652461.1\|1713135_1713693_+	hypothetical protein	NA	NA	NA	NA
WP_013158148.1\|1713859_1714642_+	HAD family hydrolase	NA	NA	NA	NA
WP_013158149.1\|1714829_1715411_-	Holliday junction branch migration protein RuvA	NA	NA	NA	NA
WP_013158150.1\|1715422_1716193_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_148225956.1\|1716189_1716687_-	DinB family protein	NA	NA	NA	NA
WP_013158152.1\|1716689_1717460_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_041653331.1\|1717509_1717842_-	cupin domain-containing protein	NA	NA	NA	NA
WP_013158154.1\|1717944_1719165_+	aspartate kinase	NA	NA	NA	NA
WP_049777805.1\|1719219_1719735_+	phosphoribosyltransferase	NA	NA	NA	NA
WP_013158156.1\|1719999_1720989_-	malate dehydrogenase	NA	NA	NA	NA
WP_013158157.1\|1721137_1721782_-	peroxidase-related enzyme	NA	NA	NA	NA
WP_013158158.1\|1721778_1722198_-	cobalamin B12-binding domain-containing protein	NA	NA	NA	NA
WP_013158159.1\|1722224_1722878_-	dienelactone hydrolase family protein	NA	NA	NA	NA
WP_013156567.1\|1723068_1724331_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	7.4e-75	40.7
WP_013158161.1\|1724717_1726373_-	methylmalonyl-CoA mutase family protein	NA	NA	NA	NA
WP_013158162.1\|1726588_1727257_-	recombination protein O N-terminal domain-containing protein	NA	NA	NA	NA
WP_013158163.1\|1727560_1727800_+	hypothetical protein	NA	NA	NA	NA
WP_013158164.1\|1727927_1729925_+	thioredoxin domain-containing protein	NA	NA	NA	NA
WP_013158165.1\|1729943_1730705_+	YmdB family metallophosphoesterase	NA	NA	NA	NA
WP_013158166.1\|1730709_1730994_-	hypothetical protein	NA	NA	NA	NA
WP_041652465.1\|1731198_1732785_+	gamma-glutamyltransferase family protein	NA	NA	NA	NA
WP_013158168.1\|1732800_1733013_-	dodecin domain-containing protein	NA	NA	NA	NA
WP_041653335.1\|1733096_1734053_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_013158170.1\|1735476_1737144_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	1.4e-134	45.6
WP_013158171.1\|1737166_1738240_-	DUF815 domain-containing protein	NA	NA	NA	NA
WP_013156567.1\|1739727_1740990_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	7.4e-75	40.7
WP_049777808.1\|1743244_1743733_-	hypothetical protein	Q859R3	Thermus_virus	1.7e-27	50.7
WP_013158173.1\|1743835_1744066_+	hypothetical protein	NA	NA	NA	NA
WP_013158174.1\|1744062_1744458_+	putative toxin-antitoxin system toxin component, PIN family	NA	NA	NA	NA
WP_083771661.1\|1746721_1747702_-\|integrase	site-specific integrase	Q859R3	Thermus_virus	2.2e-87	58.9
1750722:1750737	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1845024 : 1970053

119

Bacillus_virus(12.5%)

integrase,tRNA,protease,capsid,plate,transposase

attL 1844948:1845007|attR 1972257:1973396

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1844948:1845007	attL	NA	NA	NA	NA
WP_013158287.1\|1845024_1846182_+\|transposase	transposase	NA	NA	NA	NA
WP_013158288.1\|1846858_1848070_+	trigger factor	NA	NA	NA	NA
WP_013158289.1\|1848275_1848866_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	3.8e-50	52.3
WP_013158290.1\|1848852_1850052_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	6.7e-118	54.8
WP_013158291.1\|1850171_1850882_-	DsbA family protein	NA	NA	NA	NA
WP_013158292.1\|1850936_1851881_-	polyamine aminopropyltransferase	A0A1C9C533	Heterosigma_akashiwo_virus	9.3e-14	31.7
WP_013158293.1\|1851948_1852383_-	S-adenosylmethionine decarboxylase	NA	NA	NA	NA
WP_013158294.1\|1852389_1852848_-	hypothetical protein	NA	NA	NA	NA
WP_013158295.1\|1853035_1855828_-	DNA translocase FtsK	A0A218M9A2	Mycobacterium_phage	1.4e-81	46.7
WP_013158296.1\|1856000_1856495_-	OmpH family outer membrane protein	NA	NA	NA	NA
WP_013158297.1\|1856629_1857118_-	OmpH family outer membrane protein	NA	NA	NA	NA
WP_013158298.1\|1857366_1857810_+	hypothetical protein	NA	NA	NA	NA
WP_013158299.1\|1857957_1858392_-	DMT family transporter	NA	NA	NA	NA
WP_013158300.1\|1858393_1858975_-	TIGR00730 family Rossman fold protein	A0A1G5S9X4	Enterococcus_phage	1.8e-20	38.8
WP_013158301.1\|1859156_1860398_+	hydantoinase/carbamoylase family amidase	NA	NA	NA	NA
WP_013158302.1\|1861719_1862430_+	PucR family transcriptional regulator	NA	NA	NA	NA
WP_013158303.1\|1862509_1863844_+	aminotransferase class III-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_013158304.1\|1863984_1864401_+	hemerythrin domain-containing protein	NA	NA	NA	NA
WP_041653375.1\|1864513_1866004_+	CoA-acylating methylmalonate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_013158306.1\|1866040_1867453_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_013158307.1\|1867515_1868169_+	carbonate dehydratase	NA	NA	NA	NA
WP_013158308.1\|1868170_1868653_-	hypothetical protein	NA	NA	NA	NA
WP_041653377.1\|1868722_1869805_+	quinone-dependent dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_013158310.1\|1869815_1871135_-	dihydroorotase	NA	NA	NA	NA
WP_013158311.1\|1871159_1872104_-	aspartate carbamoyltransferase catalytic subunit	M1HWF9	Paramecium_bursaria_Chlorella_virus	8.1e-26	30.8
WP_013158312.1\|1872183_1872723_-	bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR	NA	NA	NA	NA
WP_013158313.1\|1873092_1873713_+	hypothetical protein	NA	NA	NA	NA
WP_013158314.1\|1873760_1874921_+	exonuclease SbcCD subunit D	A0A2H4UT91	Bodo_saltans_virus	1.8e-06	25.4
WP_013158315.1\|1874960_1877675_+	SMC family ATPase	G3MAB6	Bacillus_virus	8.3e-15	26.3
WP_013158316.1\|1877746_1879225_+	murein biosynthesis integral membrane protein MurJ	NA	NA	NA	NA
WP_013158317.1\|1879214_1880486_-\|tRNA	aspartate--tRNA(Asn) ligase	A0A2K9L0E9	Tupanvirus	8.0e-61	35.7
WP_013158318.1\|1880646_1881411_-	TatD family hydrolase	NA	NA	NA	NA
WP_013158319.1\|1881620_1882646_+	carotenoid 1,2-hydratase	NA	NA	NA	NA
WP_013158320.1\|1882627_1883233_-	isoprenylcysteine carboxyl methyltransferase	NA	NA	NA	NA
WP_013158321.1\|1883236_1884349_-	stilbene synthase	NA	NA	NA	NA
WP_013158322.1\|1884341_1885127_-	nitroreductase family protein	NA	NA	NA	NA
WP_013156567.1\|1885435_1886698_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	7.4e-75	40.7
WP_013158324.1\|1887815_1888556_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_083771666.1\|1888616_1888868_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_148226050.1\|1889528_1890983_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_013158326.1\|1890979_1891831_+	AAA family ATPase	NA	NA	NA	NA
WP_013158327.1\|1891909_1892269_+	hypothetical protein	NA	NA	NA	NA
WP_013158328.1\|1892277_1892715_+	hypothetical protein	NA	NA	NA	NA
WP_013158329.1\|1892884_1893196_+	hypothetical protein	NA	NA	NA	NA
WP_013158330.1\|1893192_1893432_+	hypothetical protein	NA	NA	NA	NA
WP_013158331.1\|1893579_1893810_+	hypothetical protein	NA	NA	NA	NA
WP_013158332.1\|1893802_1894078_+	hypothetical protein	NA	NA	NA	NA
WP_013158333.1\|1894070_1894289_+	hypothetical protein	NA	NA	NA	NA
WP_013158334.1\|1894298_1894694_+	hypothetical protein	NA	NA	NA	NA
WP_013158335.1\|1894779_1895259_+	hypothetical protein	NA	NA	NA	NA
WP_013158336.1\|1895255_1895957_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013158337.1\|1895946_1896387_+	hypothetical protein	NA	NA	NA	NA
WP_013158338.1\|1896443_1896692_+	hypothetical protein	NA	NA	NA	NA
WP_013158339.1\|1896701_1897043_+	hypothetical protein	NA	NA	NA	NA
WP_013158340.1\|1897044_1897365_+	hypothetical protein	NA	NA	NA	NA
WP_083771667.1\|1897300_1897837_+	DUF3486 family protein	NA	NA	NA	NA
WP_013158342.1\|1897823_1899107_+	hypothetical protein	A0A2P9JZI8	Alteromonadaceae_phage	4.4e-99	48.1
WP_013158343.1\|1899106_1900642_+	DUF935 family protein	A0A2K9VGW6	Faecalibacterium_phage	3.3e-77	37.4
WP_013158344.1\|1900643_1901816_+\|capsid	minor capsid protein	H7BVL6	unidentified_phage	5.5e-24	30.0
WP_013157655.1\|1901827_1903027_-\|transposase	transposase	I4AZM3	Saccharomonospora_phage	1.5e-53	40.5
WP_041652367.1\|1903027_1903426_-\|transposase	IS200/IS605 family transposase	A0A1L2BWN1	Bacteriophage	2.3e-35	52.3
WP_013158345.1\|1903663_1904203_+	hypothetical protein	NA	NA	NA	NA
WP_174263509.1\|1904256_1904703_+	phage virion morphogenesis protein	A0A2K9VH22	Faecalibacterium_phage	6.7e-15	43.7
WP_013158347.1\|1904783_1905284_+	hypothetical protein	NA	NA	NA	NA
WP_013158348.1\|1905294_1905507_+	hypothetical protein	NA	NA	NA	NA
WP_013158349.1\|1905503_1906925_+	hypothetical protein	NA	NA	NA	NA
WP_013158350.1\|1906935_1907367_+	hypothetical protein	NA	NA	NA	NA
WP_013158351.1\|1907425_1907800_+	hypothetical protein	NA	NA	NA	NA
WP_169307840.1\|1907804_1907966_-	hypothetical protein	NA	NA	NA	NA
WP_013158353.1\|1907950_1910032_+	hypothetical protein	NA	NA	NA	NA
WP_013158354.1\|1910031_1910610_+	hypothetical protein	NA	NA	NA	NA
WP_013158355.1\|1910606_1911272_+	hypothetical protein	NA	NA	NA	NA
WP_013158356.1\|1911273_1911750_+	hypothetical protein	NA	NA	NA	NA
WP_013158357.1\|1911749_1912124_+	hypothetical protein	NA	NA	NA	NA
WP_013158358.1\|1912116_1913199_+\|plate	baseplate J/gp47 family protein	NA	NA	NA	NA
WP_013158359.1\|1913199_1913811_+	hypothetical protein	NA	NA	NA	NA
WP_013158360.1\|1913818_1914973_+	hypothetical protein	I3VYV3	Thermoanaerobacterium_phage	1.9e-05	41.3
WP_013158361.1\|1914987_1915164_+	hypothetical protein	NA	NA	NA	NA
WP_013156564.1\|1915689_1916721_-\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA
WP_013158363.1\|1916871_1917153_-	hypothetical protein	NA	NA	NA	NA
WP_013158364.1\|1917167_1918559_-	phosphoglucomutase/phosphomannomutase family protein	A0A1X9I671	Streptococcus_phage	2.2e-27	27.0
WP_041652509.1\|1918914_1921074_+	UvrD-helicase domain-containing protein	A7KV33	Bacillus_phage	6.2e-122	40.1
WP_013158366.1\|1921335_1921779_+	hypothetical protein	NA	NA	NA	NA
WP_013158367.1\|1921847_1922570_+	hypothetical protein	NA	NA	NA	NA
WP_013158368.1\|1922644_1923034_-	30S ribosomal protein S9	NA	NA	NA	NA
WP_013158369.1\|1923033_1923462_-	50S ribosomal protein L13	NA	NA	NA	NA
WP_013158370.1\|1923648_1923945_+	4a-hydroxytetrahydrobiopterin dehydratase	NA	NA	NA	NA
WP_013158371.1\|1924002_1926762_+	2-oxoglutarate dehydrogenase E1 component	NA	NA	NA	NA
WP_013158372.1\|1926960_1928229_+	2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase	NA	NA	NA	NA
WP_013158373.1\|1928288_1929668_+	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	1.7e-32	26.3
WP_013158374.1\|1929791_1931342_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	1.5e-77	38.1
WP_041652511.1\|1931435_1935185_+	methionine synthase	A0A140XBC7	Dickeya_phage	2.8e-05	48.2
WP_013158376.1\|1935376_1937107_-	DNA polymerase/3'-5' exonuclease PolX	NA	NA	NA	NA
WP_013158377.1\|1937170_1938184_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_013158378.1\|1938369_1938993_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013158379.1\|1939147_1940758_+	Na/Pi cotransporter family protein	NA	NA	NA	NA
WP_013158380.1\|1940857_1941994_+	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_013158381.1\|1942402_1943221_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	8.0e-22	30.3
WP_013158382.1\|1943288_1944116_+	ABC transporter permease	NA	NA	NA	NA
WP_013158383.1\|1944257_1944797_+	hypothetical protein	NA	NA	NA	NA
WP_013158384.1\|1944897_1945620_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	9.2e-22	29.0
WP_013158385.1\|1945616_1946783_+	ABC transporter permease	NA	NA	NA	NA
WP_013158386.1\|1946848_1947988_-	dehypoxanthine futalosine cyclase	NA	NA	NA	NA
WP_013158387.1\|1948049_1948688_-	glycosyltransferase	NA	NA	NA	NA
WP_013158388.1\|1948866_1949913_-\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_013158389.1\|1949930_1951055_-	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_049777811.1\|1951079_1951967_-	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_013158391.1\|1952094_1952652_-	ribosome recycling factor	NA	NA	NA	NA
WP_013158392.1\|1952748_1953453_-	UMP kinase	NA	NA	NA	NA
WP_013158393.1\|1953528_1954119_-	translation elongation factor Ts	NA	NA	NA	NA
WP_013158394.1\|1954127_1954883_-	30S ribosomal protein S2	NA	NA	NA	NA
WP_041652517.1\|1956228_1957164_+	NAD(+)/NADH kinase	NA	NA	NA	NA
WP_013158397.1\|1957386_1958520_+	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_013158398.1\|1958529_1962174_-	alpha-amylase	NA	NA	NA	NA
WP_049777894.1\|1962269_1963484_-	aminopeptidase	NA	NA	NA	NA
WP_013158400.1\|1963556_1964642_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_013158401.1\|1964634_1965798_-	lipid-A-disaccharide synthase	NA	NA	NA	NA
WP_013158402.1\|1966046_1969013_+	transcription-repair coupling factor	NA	NA	NA	NA
WP_013158403.1\|1969129_1970053_-\|transposase	IS982 family transposase	NA	NA	NA	NA
1972257:1973396	attR	NA	NA	NA	NA

DBSCAN-SWA_4

2488633 : 2498070

Paramecium_bursaria_Chlorella_virus(25.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013158846.1\|2488633_2490472_+\|tRNA	arginine--tRNA ligase	A0A2I2L3K1	Orpheovirus	1.2e-17	22.7
WP_013158847.1\|2490477_2491554_+	trypsin-like peptidase domain-containing protein	A0A1B1IT49	uncultured_Mediterranean_phage	1.9e-15	23.4
WP_013158848.1\|2491629_2492247_+	deoxynucleoside kinase	Q5ULP7	Lactobacillus_virus	3.4e-25	33.9
WP_013158849.1\|2492283_2492928_+	deoxynucleoside kinase	A0A192GP17	Short-finned_eel_ranavirus	5.2e-08	29.0
WP_013158850.1\|2493009_2494014_+	agmatine deiminase family protein	M1HLE1	Paramecium_bursaria_Chlorella_virus	5.0e-58	32.8
WP_013158851.1\|2494024_2494900_+	N-carbamoylputrescine amidase	A7ITI3	Paramecium_bursaria_Chlorella_virus	6.1e-68	46.6
WP_013158852.1\|2494971_2497008_+	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	1.2e-21	34.6
WP_013158853.1\|2497038_2498070_-	sensor domain-containing diguanylate cyclase	G3MA91	Bacillus_virus	1.3e-13	31.6

DBSCAN-SWA_5

2690867 : 2753525

Streptococcus_phage(40.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013156564.1\|2690867_2691899_-\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA
WP_013159040.1\|2691971_2692778_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_013159041.1\|2692789_2693782_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_013159042.1\|2693788_2694766_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_049777908.1\|2694831_2695635_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_013159044.1\|2695757_2696672_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_013159045.1\|2696740_2698009_-	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013159046.1\|2698361_2700941_+	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	1.4e-99	38.1
WP_013159047.1\|2700978_2701239_+	hypothetical protein	NA	NA	NA	NA
WP_013159048.1\|2701226_2701802_+	LysE family transporter	NA	NA	NA	NA
WP_013159049.1\|2701757_2702303_-	NYN domain-containing protein	NA	NA	NA	NA
WP_013159050.1\|2703637_2703907_-	hypothetical protein	NA	NA	NA	NA
WP_013159051.1\|2703955_2704855_-	hypothetical protein	NA	NA	NA	NA
WP_049777822.1\|2704982_2705705_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_041652639.1\|2705722_2705950_+	hypothetical protein	NA	NA	NA	NA
WP_013159052.1\|2706049_2706454_-	hypothetical protein	NA	NA	NA	NA
WP_013156564.1\|2706489_2707521_-\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA
WP_013157594.1\|2707729_2709346_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_049777823.1\|2709442_2710522_-	hypothetical protein	NA	NA	NA	NA
WP_013159054.1\|2710820_2711972_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	7.7e-55	38.0
WP_013159055.1\|2711990_2713244_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	6.6e-84	44.4
WP_013159056.1\|2713452_2714253_+	YihY/virulence factor BrkB family protein	NA	NA	NA	NA
WP_013159057.1\|2714409_2715651_+	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_013159058.1\|2715731_2716865_+	DUF5009 domain-containing protein	NA	NA	NA	NA
WP_013159059.1\|2717053_2717434_-	50S ribosomal protein L7/L12	NA	NA	NA	NA
WP_013159060.1\|2717476_2718001_-	50S ribosomal protein L10	NA	NA	NA	NA
WP_013159061.1\|2718170_2719286_-\|transposase	transposase	NA	NA	NA	NA
WP_013159062.1\|2719369_2720305_-	acetamidase/formamidase family protein	NA	NA	NA	NA
WP_013159063.1\|2720327_2722625_+	xanthine dehydrogenase family protein molybdopterin-binding subunit	NA	NA	NA	NA
WP_013159064.1\|2722621_2723452_+	tryptophan 2,3-dioxygenase	NA	NA	NA	NA
WP_013159065.1\|2723558_2724674_+	exo-alpha-sialidase	NA	NA	NA	NA
WP_013159066.1\|2724670_2724967_+	MoaD/ThiS family protein	NA	NA	NA	NA
WP_013159067.1\|2725131_2726106_-	YafY family transcriptional regulator	NA	NA	NA	NA
WP_013159068.1\|2726178_2727102_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_013159069.1\|2727303_2727993_-	50S ribosomal protein L1	NA	NA	NA	NA
WP_013159070.1\|2727985_2728420_-	50S ribosomal protein L11	NA	NA	NA	NA
WP_013159071.1\|2728528_2729086_-	transcription termination/antitermination factor NusG	NA	NA	NA	NA
WP_013159072.1\|2729099_2729321_-	preprotein translocase subunit SecE	NA	NA	NA	NA
WP_013159073.1\|2729320_2729485_-	50S ribosomal protein L33	NA	NA	NA	NA
WP_013159074.1\|2729559_2730777_-	elongation factor Tu	A0A1V0SC62	Catovirus	1.8e-06	27.7
WP_013159076.1\|2732806_2734159_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_041653557.1\|2734231_2736007_-	hypothetical protein	NA	NA	NA	NA
WP_013159078.1\|2736109_2736571_-	carbon monoxide dehydrogenase subunit G	NA	NA	NA	NA
WP_013159079.1\|2736654_2737263_+	nucleotidyltransferase family protein	NA	NA	NA	NA
WP_013159080.1\|2737569_2738064_+	(2Fe-2S)-binding protein	A0A0P0IVM8	Acinetobacter_phage	5.3e-21	37.1
WP_013159081.1\|2738144_2740514_+	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_013159082.1\|2740612_2741440_+	xanthine dehydrogenase family protein subunit M	NA	NA	NA	NA
WP_041652646.1\|2741522_2742422_+	MoxR family ATPase	NA	NA	NA	NA
WP_013159084.1\|2742427_2743642_+	VWA domain-containing protein	NA	NA	NA	NA
WP_013159085.1\|2743660_2744779_-	XdhC family protein	NA	NA	NA	NA
WP_013159086.1\|2744836_2745388_-	molybdenum cofactor guanylyltransferase	NA	NA	NA	NA
WP_041653558.1\|2745464_2747048_-	sensor histidine kinase	NA	NA	NA	NA
WP_013159088.1\|2747119_2747437_-	hypothetical protein	NA	NA	NA	NA
WP_013159089.1\|2747492_2748254_-	RNA methyltransferase	NA	NA	NA	NA
WP_013159090.1\|2748277_2750464_-	penicillin-binding protein	NA	NA	NA	NA
WP_013159091.1\|2750517_2750919_-	response regulator	NA	NA	NA	NA
WP_013156564.1\|2750999_2752031_+\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA
WP_083771679.1\|2753360_2753525_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_6

2792790 : 2801373

Tupanvirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013159129.1\|2792790_2795109_-	GDP-mannose 4,6-dehydratase	A0A2K9KZK0	Tupanvirus	3.9e-29	38.9
WP_013159130.1\|2795116_2796544_-	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	6.4e-67	35.3
WP_041652656.1\|2796557_2797550_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	9.9e-67	42.0
WP_041652658.1\|2797611_2798145_-	dTDP-4-dehydrorhamnose 3,5-epimerase family protein	NA	NA	NA	NA
WP_013159133.1\|2798141_2798864_-	NAD(P)-dependent oxidoreductase	A0A291LA50	Escherichia_phage	3.1e-17	40.0
WP_013159134.1\|2798860_2799928_-	glucose-1-phosphate thymidylyltransferase	G3MA50	Bacillus_virus	1.0e-40	35.4
WP_013159135.1\|2799942_2801373_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	2.6e-44	27.3

DBSCAN-SWA_7

3092720 : 3138042

Burkholderia_virus(14.29%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148225922.1\|3092720_3093843_+\|transposase	IS3-like element ISMesi1 family transposase	Q8W6R2	Burkholderia_virus	1.8e-16	30.6
WP_083771691.1\|3094182_3094413_+	nucleoside hydrolase	NA	NA	NA	NA
WP_013159417.1\|3094468_3095986_+	FGGY-family carbohydrate kinase	NA	NA	NA	NA
WP_013159418.1\|3096004_3097540_-	xylulokinase	NA	NA	NA	NA
WP_169307872.1\|3098036_3098783_+	DeoR family transcriptional regulator	NA	NA	NA	NA
WP_013159420.1\|3098779_3099823_+	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_083771692.1\|3099823_3101221_+	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013159422.1\|3101309_3101870_+	SIS domain-containing protein	NA	NA	NA	NA
WP_013159423.1\|3101872_3102745_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_013159424.1\|3102757_3103618_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_013159425.1\|3104127_3105060_+	sugar phosphate isomerase/epimerase	NA	NA	NA	NA
WP_169307873.1\|3105148_3105589_-	hypothetical protein	NA	NA	NA	NA
WP_013156567.1\|3105669_3106932_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	7.4e-75	40.7
WP_013159427.1\|3107083_3109249_-	glutamine synthetase III	NA	NA	NA	NA
WP_013159428.1\|3109471_3110239_+	nucleoside phosphorylase	NA	NA	NA	NA
WP_013159429.1\|3110600_3112019_-	xylulokinase	NA	NA	NA	NA
WP_013159430.1\|3112046_3113444_-	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_041653695.1\|3113564_3114191_-	membrane protein	NA	NA	NA	NA
WP_049777847.1\|3114234_3115005_-	hypothetical protein	NA	NA	NA	NA
WP_013159433.1\|3115112_3116234_-	ABC transporter permease	NA	NA	NA	NA
WP_049777918.1\|3116230_3117124_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	2.8e-20	28.2
WP_013159435.1\|3117134_3117767_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_169307874.1\|3117812_3117950_-	hypothetical protein	NA	NA	NA	NA
WP_148226000.1\|3117973_3118153_-	hypothetical protein	NA	NA	NA	NA
WP_041652458.1\|3118233_3118665_-\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	2.4e-09	34.9
WP_013159436.1\|3118737_3119343_-	nitroreductase	NA	NA	NA	NA
WP_013159437.1\|3119475_3121341_-	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_041652711.1\|3121466_3121679_-	hypothetical protein	NA	NA	NA	NA
WP_041653705.1\|3121737_3122109_-	hypothetical protein	NA	NA	NA	NA
WP_013159440.1\|3122113_3122998_-	ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	5.4e-16	28.6
WP_049777919.1\|3122990_3124031_-	iron ABC transporter permease	NA	NA	NA	NA
WP_013159442.1\|3124030_3124906_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013159443.1\|3125357_3126473_+\|transposase	transposase	NA	NA	NA	NA
WP_169307875.1\|3126783_3128004_+	RtcB family protein	A0A1I9SAD2	Rhodococcus_phage	1.0e-33	30.1
WP_169307876.1\|3128058_3128232_-	hypothetical protein	NA	NA	NA	NA
WP_169307877.1\|3128861_3129005_+	hypothetical protein	NA	NA	NA	NA
WP_013159446.1\|3129008_3130961_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_013159447.1\|3131069_3131495_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	NA	NA	NA	NA
WP_013159448.1\|3131528_3132392_-	prolyl oligopeptidase family serine peptidase	NA	NA	NA	NA
WP_013159449.1\|3132478_3133654_-	MFS transporter	NA	NA	NA	NA
WP_013159450.1\|3133658_3134534_-	P1 family peptidase	NA	NA	NA	NA
WP_013159451.1\|3134562_3135069_-	metal-binding protein	NA	NA	NA	NA
WP_013159452.1\|3135290_3136511_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A068A1P5	Thermus_phage	4.3e-96	46.6
WP_013159453.1\|3136965_3138042_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_8

3151861 : 3218288

Mycobacterium_phage(14.29%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013159465.1\|3151861_3152932_+\|transposase	transposase	NA	NA	NA	NA
WP_013156567.1\|3153048_3154311_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	7.4e-75	40.7
WP_041652720.1\|3156224_3156722_+	NUDIX hydrolase	NA	NA	NA	NA
WP_049777920.1\|3156874_3157543_+	thioredoxin family protein	NA	NA	NA	NA
WP_013159468.1\|3157572_3158487_-	methylmalonyl Co-A mutase-associated GTPase MeaB	NA	NA	NA	NA
WP_013159469.1\|3158585_3158957_-	RidA family protein	NA	NA	NA	NA
WP_013159470.1\|3159024_3159219_+	hypothetical protein	NA	NA	NA	NA
WP_013159471.1\|3159276_3160236_-	Stp1/IreP family PP2C-type Ser/Thr phosphatase	NA	NA	NA	NA
WP_041653713.1\|3160517_3163241_+	pyruvate dehydrogenase (acetyl-transferring), homodimeric type	NA	NA	NA	NA
WP_013159473.1\|3163273_3164560_+	2-oxo acid dehydrogenase subunit E2	NA	NA	NA	NA
WP_013159474.1\|3164798_3166691_+	biosynthetic arginine decarboxylase	NA	NA	NA	NA
WP_013159475.1\|3166811_3167876_+	GGDEF domain-containing protein	NA	NA	NA	NA
WP_013159476.1\|3167887_3169063_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	4.1e-128	62.1
WP_148226001.1\|3169246_3171760_-	GAF domain-containing protein	NA	NA	NA	NA
WP_013159478.1\|3171976_3172891_-	DUF4032 domain-containing protein	NA	NA	NA	NA
WP_013159479.1\|3173054_3174308_+	DUF4127 family protein	NA	NA	NA	NA
WP_013159480.1\|3174317_3174632_-	hypothetical protein	NA	NA	NA	NA
WP_169307878.1\|3174718_3174871_+	hypothetical protein	NA	NA	NA	NA
WP_013159482.1\|3175182_3175842_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_013159483.1\|3175832_3176756_+	proline dehydrogenase family protein	NA	NA	NA	NA
WP_013159484.1\|3176830_3177235_+	ACT domain-containing protein	NA	NA	NA	NA
WP_013159485.1\|3177276_3178824_+	L-glutamate gamma-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_013159486.1\|3178989_3179451_-	HD domain-containing protein	NA	NA	NA	NA
WP_013159235.1\|3179592_3180414_-\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_049777849.1\|3182414_3182981_+\|transposase	transposase	A0A1I9KF42	Aeromonas_phage	1.2e-08	38.5
WP_083771696.1\|3183216_3183327_+	hypothetical protein	NA	NA	NA	NA
WP_049777850.1\|3183348_3183606_+	hypothetical protein	NA	NA	NA	NA
WP_169307879.1\|3183565_3183811_+	hypothetical protein	NA	NA	NA	NA
WP_013159488.1\|3183819_3184128_-	hypothetical protein	NA	NA	NA	NA
WP_013159489.1\|3184115_3184958_-	Ig-like domain-containing protein	NA	NA	NA	NA
WP_013159490.1\|3184991_3185198_-	hypothetical protein	NA	NA	NA	NA
WP_148226082.1\|3185194_3185932_-	hypothetical protein	NA	NA	NA	NA
WP_013159493.1\|3187096_3187456_-	DUF1634 domain-containing protein	NA	NA	NA	NA
WP_013159494.1\|3187452_3188295_-	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_013159495.1\|3188391_3189834_+	glucose-6-phosphate dehydrogenase	E3SJC5	Synechococcus_phage	3.1e-77	36.8
WP_013159496.1\|3189833_3192119_+	glucan 1,4-alpha-glucosidase	NA	NA	NA	NA
WP_013159497.1\|3192124_3192745_+	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_013159498.1\|3193551_3194862_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_013159499.1\|3194858_3195539_-	response regulator transcription factor	NA	NA	NA	NA
WP_013159500.1\|3195603_3196923_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_013159501.1\|3196919_3197576_-	response regulator transcription factor	NA	NA	NA	NA
WP_013159502.1\|3197579_3198236_-	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_013159503.1\|3198243_3198981_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_041653720.1\|3198977_3200138_-	beta-propeller fold lactonase family protein	NA	NA	NA	NA
WP_013159505.1\|3200840_3201251_-	PepSY domain-containing protein	NA	NA	NA	NA
WP_013159506.1\|3201501_3201714_-	hypothetical protein	NA	NA	NA	NA
WP_013159508.1\|3202001_3203258_-	O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase	A0A0B5JD48	Pandoravirus	2.1e-13	28.3
WP_013159509.1\|3203525_3204944_-	hypothetical protein	A0A1L2BWY3	Bacteriophage	4.8e-14	32.0
WP_013159510.1\|3205037_3206795_+	alkaline phosphatase	NA	NA	NA	NA
WP_013159511.1\|3207307_3207949_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.6e-28	40.6
WP_013159512.1\|3207945_3209145_+	ABC transporter permease	NA	NA	NA	NA
WP_148226083.1\|3209702_3210569_-\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_013159516.1\|3210563_3211247_+	aquaporin	NA	NA	NA	NA
WP_013159517.1\|3211262_3211928_-	uracil-DNA glycosylase	NA	NA	NA	NA
WP_013159519.1\|3212274_3213840_-	acyl-CoA carboxylase subunit beta	NA	NA	NA	NA
WP_013156869.1\|3217166_3218288_-\|transposase	transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_014213

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CRISPR-Cas detection and classification

Crispr_ID: NC_014213_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014213_1

125440-125762

Orphan

I-C,III-B

Consensus_repeat	Method
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	PILER-CR
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	CRISPRCasFinder
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	CRT

4 spacers

The CRISPR arrays of NC_014213_1

>merge|NC_014213|1|125440-125762|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAACTTTCTAAGGCGCTCCTAGACAAGCCTCAATGTCTGTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAACCTTTGGCCTAATCACACCATTGGAATATTTCAAGGTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAACCAGAATTGTATTTAGGTATTCCTGTGTAGTCAGTCCGTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAACGGCAGTAAGTATTGACAAGCCGCTCGAGTTATGCGTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC

>NC_014213|1|1|125440-125762|PILER-CR
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	TTTCTAAGGCGCTCCTAGACAAGCCTCAATGTCT
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	CTTTGGCCTAATCACACCATTGGAATATTTCAAG
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	CAGAATTGTATTTAGGTATTCCTGTGTAGTCAGTCC
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	GGCAGTAAGTATTGACAAGCCGCTCGAGTTATGC
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC

>NC_014213|1|1|125440-125762|CRISPRCasFinder
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	TTTCTAAGGCGCTCCTAGACAAGCCTCAATGTCT
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	CTTTGGCCTAATCACACCATTGGAATATTTCAAG
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	CAGAATTGTATTTAGGTATTCCTGTGTAGTCAGTCC
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	GGCAGTAAGTATTGACAAGCCGCTCGAGTTATGC
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC

>NC_014213|1|1|125440-125762|CRT
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	TTTCTAAGGCGCTCCTAGACAAGCCTCAATGTCT
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	CTTTGGCCTAATCACACCATTGGAATATTTCAAG
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	CAGAATTGTATTTAGGTATTCCTGTGTAGTCAGTCC
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	GGCAGTAAGTATTGACAAGCCGCTCGAGTTATGC
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014213.1\|WP_013159665.1\|129053_130448_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173810
NC_014213.1\|WP_013159668.1\|131120_132596_-\|DUF2867-domain-containing-protein	unknown	unknown	gnl\|CDD\|187556
NC_014213.1\|WP_013156567.1\|125888_127151_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NC_014213.1\|WP_013159669.1\|132748_133825_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270400
NC_014213.1\|WP_013159667.1\|130751_130973_-\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_013159659.1\|121203_122046_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226616
NC_014213.1\|WP_013159661.1\|122800_123850_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NC_014213.1\|WP_148226099.1\|117797_118724_-\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_169307903.1\|117199_117529_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350249
NC_014213.1\|WP_013159653.1\|113654_115856_+\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NC_014213.1\|WP_013159666.1\|130529_130736_-\|twin-arginine-translocase-TatA/TatE-family-subunit	unknown	unknown	gnl\|CDD\|237837
NC_014213.1\|WP_013159660.1\|122042_122801_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224098
NC_014213.1\|WP_013159671.1\|134884_136033_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226651
NC_014213.1\|WP_013159657.1\|118943_120029_+\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_014213.1\|WP_148226090.1\|128039_128669_+\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_013159664.1\|128744_129023_+\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_049777932.1\|113170_113617_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_014213.1\|WP_013159658.1\|120120_121191_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270267
NC_014213.1\|WP_013159654.1\|115942_117013_+\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|239584
NC_014213.1\|WP_013159670.1\|134196_134868_-\|diphthine--ammonia-ligase	unknown	unknown	gnl\|CDD\|238952

Protein	Function_ID	Function_description	E-value
NC_014213.1\|WP_013159665.1\|129053_130448_-\|S8-family-serine-peptidase	gnl\|CDD\|173810	cd07484, Peptidases_S8_Thermitase_like, Peptidase S8 family domain in Thermitase-like proteins. Thermitase is a non-specific, trypsin-related serine protease with a very high specific activity. It contains a subtilisin like domain. The tertiary structure of thermitase is similar to that of subtilisin BPN'. It contains a Asp/His/Ser catalytic triad. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) clan include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53 the it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	6.55811e-55
NC_014213.1\|WP_013159668.1\|131120_132596_-\|DUF2867-domain-containing-protein	gnl\|CDD\|187556	cd05245, SDR_a2, atypical (a) SDRs, subgroup 2. This subgroup contains atypical SDRs, one member is identified as Escherichia coli protein ybjT, function unknown. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that generally matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.7064e-124
NC_014213.1\|WP_013156567.1\|125888_127151_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	4.31519e-57
NC_014213.1\|WP_013159669.1\|132748_133825_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270400	cd13682, PBP2_TRAP_alpha-ketoacid, Substrate-binding component of an alpha-keto acid binding Tripartite ATP-independent Periplasmic transporter and related proteins; contains the type 2 periplasmic-binding protein fold. This subgroup includes TRAP transporters that bind to ketoacids such as pyruvate and alpha-ketobutyrate, xylulose, and other unknown ligands. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.08866e-176
NC_014213.1\|WP_013159659.1\|121203_122046_+\|ABC-transporter-permease-subunit	gnl\|CDD\|226616	COG4132, COG4132, ABC-type uncharacterized transport system, permease component [General function prediction only].	6.63732e-71
NC_014213.1\|WP_013159661.1\|122800_123850_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	1.27074e-148
NC_014213.1\|WP_169307903.1\|117199_117529_+\|hypothetical-protein	gnl\|CDD\|350249	cd18682, PIN_VapC-like, Uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.0621e-26
NC_014213.1\|WP_013159653.1\|113654_115856_+\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	2.3929e-75
NC_014213.1\|WP_013159666.1\|130529_130736_-\|twin-arginine-translocase-TatA/TatE-family-subunit	gnl\|CDD\|237837	PRK14861, tatA, twin arginine translocase protein A; Provisional.	2.82518e-11
NC_014213.1\|WP_013159660.1\|122042_122801_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	2.08194e-33
NC_014213.1\|WP_013159671.1\|134884_136033_-\|hypothetical-protein	gnl\|CDD\|226651	COG4188, COG4188, Predicted dienelactone hydrolase [General function prediction only].	2.52754e-22
NC_014213.1\|WP_013159657.1\|118943_120029_+\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	8.70275e-18
NC_014213.1\|WP_049777932.1\|113170_113617_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.35496e-21
NC_014213.1\|WP_013159658.1\|120120_121191_+\|extracellular-solute-binding-protein	gnl\|CDD\|270267	cd13549, PBP2_Fbp_like_3, Substrate binding domain of an uncharacterized ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. This periplasmic domain (Fbp) has high affinity for ferric iron and serves as the primary receptor for transport. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.10012e-60
NC_014213.1\|WP_013159654.1\|115942_117013_+\|fatty-acid-desaturase	gnl\|CDD\|239584	cd03507, Delta12-FADS-like, The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of organisms including higher plants, green algae, diatoms, nematodes, fungi, and bacteria. The expression of these proteins appears to be temperature dependent: decreases in temperature result in increased levels of fatty acid desaturation within membrane lipids subsequently altering cell membrane fluidity. An important enzyme for the production of polyunsaturates in plants is the oleate delta-12 desaturase (Arabidopsis FAD2) of the endoplasmic reticulum. This enzyme accepts l-acyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate and requires NADH:cytochrome b oxidoreductase, cytochrome b, and oxygen for activity. FAD2 converts oleate(18:1) to linoleate (18:2) and is closely related to oleate 12-hydroxylase which catalyzes the hydroxylation of oleate to ricinoleate. Plastid-bound desaturases (Arabidopsis delta-12 desaturase (FAD6), omega-3 desaturase (FAD8), omega-6 desaturase (FAD6)), as well as, the cyanobacterial thylakoid-bound FADSs require oxygen, ferredoxin, and ferredoxin oxidoreductase for activity. As in higher plants, the cyanobacteria delta-12 (DesA) and omega-3 (DesB) FADSs desaturate oleate (18:1) to linoleate (18:2) and linoleate (18:2) to linolenate (18:3), respectively. Omega-3 (DesB/FAD8) and omega-6 (DesD/FAD6) desaturases catalyze reactions that introduce a double bond between carbons three and four, and carbons six and seven, respectively, from the methyl end of fatty acids. As with other members of this superfamily, this domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain eight histidine residues: HXXXH, HXX(X)HH, and HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homologue, stearoyl CoA desaturase. Mutation of any one of four of these histidines in the Synechocystis delta-12 acyl-lipid desaturase resulted in complete inactivity.	4.35147e-69
NC_014213.1\|WP_013159670.1\|134196_134868_-\|diphthine--ammonia-ligase	gnl\|CDD\|238952	cd01994, Alpha_ANH_like_IV, This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily of proteins is predicted to bind ATP. This domainhas a strongly conserved motif SGGKD at the N terminus.	2.96931e-63

>NC_014213.1|WP_013159661.1|122800_123850_+|ABC-transporter-ATP-binding-protein
MAALRLEGLRRRFGNVEALAAFNLEVASGELVTLLGPSGCGKTTLLRIVAGFEQPDAGQVWLEGEDITKTPPNRRHMGMVFQAYSLFPNMSAEENVRFGLRLRGLSRAEQEQRLSELFRLIGLEDVRKRYPHQLSGGQQQRIALARALAPRPKVLLMDEPLSALDAQVRQTLREEIRRIQQAEKITTLFVTHDQEEALTLSDRVVVMNRGKIEQVGSPREVYLRPASAFVAGFVGVSSVLEGEWLTGNRVRTAAGSLIVAPGEHPVGAKVKVFLRPENLRLAKPGGEGLEGRIEENVFMGSFVRVRVRLRDGQSLWIDQGLEEAVQWQIGDEVKVDNASSLGHGVVVLG
>NC_014213.1|WP_013159660.1|122042_122801_+|ABC-transporter-permease-subunit
MTRRLLLALFGLYFLLPLLATAIYSLWAGGQRYDLSAYARILGDPQFRSSFTLSFTLAVETVVLSLLLLIPAVFWANLRWPGLRALLEVVSVMPFVVPPIALVGGLTALYKGPAWWIGSPQFLIVGYTVLALPYTYRALDAGMRAIDLKTLSEAALSLGSSWLGLLLRVVVPCILPSILSAALLTLAIVMGEFTFANVLLFNTFAVYINYVGQTQGTGAAALSLLSFALTWLAMIAILRSGRQGQPSLGGGR
>NC_014213.1|WP_013159659.1|121203_122046_+|ABC-transporter-permease-subunit
MEWLNRLLFSGPLLLFVGAFLLLPSLQLGYLALSDGHGGLTVRYLEALGQPQYRVAFQNSILLSGTTAVLGGILGTMLAFLTSAGRGWLAEAVTAFNGVAANFAGVPLAFAFIATLGTTGLLTQFLRQALGLDLYGLGFSLFSYWGLVVVYLYFQIPLMFLVMAPVVSGLRREWREAAYGLGATPFQYWTRVVFPLILPATLAGTILLFGNAFSAYATPYALTSGVLPLVPLQIGSALQGNVSADPQQGAALALGMVALMLASLGLYLALARRHSRWRNQ
>NC_014213.1|WP_013159658.1|120120_121191_+|extracellular-solute-binding-protein
MRYKRALTRREVLRLGGVATGSLTLGLLMKGQAQSKTLNTIALPPDWANYGEIMATFTKKYGITINNASPNASSAEELQALRSLKGQSRAPDVVDVGPSFAIQGKQEGLFAPYKVSTWDSIPANMKDPDGYWYGDYFGVISFGVNASVVKKVPKTWADLKDPAYKGQIALNGSPLTAGAAFAGVWAAALANGGSLDDITPGIDFFAQLKKMGNYIPVDATPATVQTGQTPIVVDWDYLNLGYSKEFAGKLDWRVSVPEDGVYGSYYCQAISAFAPNPASARQWMEFLYSDEGQLLFLKGYAHPVRFNDMLRRKVIPTELLAKLPPSEPYTKVRFATQEQLKKAQETLKAQWAAKVG
>NC_014213.1|WP_013159657.1|118943_120029_+|transposase
MQFTTVGREIWRGARQAQRLAEANASDPEVQERLRKLRLVKALRESKKSWKEIQDLVGISRATYHRWQKALKEKGLAGLKPRSRRPKHLRTKVHWTPGLLIRIETLRKENPTWGRWSIWLTLRKEGFQMSERTVGRILAYLEKHRRIESVAGYLARTQRGKLKRRVNRPYAKRKPRGYEARAPGDLVQVDTLTLTLGPGSMVKHFSAIDLHSRFVLAEVHSRATAKLSEGFLSLLLARAPFPIRAIQVDGGSEFMAEFEEACCALGIALFVLPPRSPKLNGHVERMQRTFKEEFYTRPLPTPLSELQAELDTYLDYYNRRRPHMALGGLAPLEFLAKMQEESVPQRVSNVLTDYRMLAVLP
>NC_014213.1|WP_148226099.1|117797_118724_-|hypothetical-protein
MVLIAVMLATSFALAERFSFVAIGDMPYGEMAPFENLVKAINAARPSFTVHVGDIKSGSSPCTDAYMLKIRDLFNTFSAPLVYTPGDNEWTDCHREKAGKYDPIERLAFVRQTFFTNNQSFGAQKMTLEQQSADPKFAKFVENERWSLGGVVFATLHVVGSNNNLQRNQAAVNEYIERNAANLSWLESTFAKASSEGAKAVVLFWQADPMFEETSEDKRSGFTEILALLKSKVKAFGRPVLLVHGDSHTFIVDQPWYSESDASNIGNFYRLEVYGSARVHAVQVEVDTDTPGIFSFRPLMVRENLPKN
>NC_014213.1|WP_169307903.1|117199_117529_+|hypothetical-protein
MEDALEHGVLSAVTFTEVLGKLVGKGVPADQAEADLDELGLEVVDYDRELAKVAAYFYARRNPYNLSLGACAVLALGEHLGLPILTGEQAWAKLPGLRVKVRLIRKVMP
>NC_014213.1|WP_013159654.1|115942_117013_+|fatty-acid-desaturase
MDTSKLQPKDWIPLIKPYAKPDLRRSLHQVGNTLLPLLLLFYLAYLALSVSVVLTLALDFVAALFVVRLFILQHDAGHGSFFPKKWANDLLGFFAGILTLVPYHHWQLSHARHHATSGNLDKRGVGDIYTLTLTEYLRASPWERLKYRIYRNPLVMFLVGPIYTFMLSYRLPLGFGADKPLVRNSVALTNLFLVLLWVGIALGFGLKTLLWVYLPIQYFAGMVGIFLFYVQHQFEDAYWEHDPRWEHLKSAMEGSTYLKLPKPLQWLTGNIGFHHIHHLSPKIPNYNLERVQQEVDLVQVAPTVTLRDAFAIAFADLHLHDEESRKLMGFREAGRRIREARRAQAKSGYPGYQSAP
>NC_014213.1|WP_013159653.1|113654_115856_+|YhgE/Pip-domain-containing-protein
MPPSFQTSSSPTAKLGFWSFLARELVHVGSNRQVVLLLLGIALLPALFALIQITSAWDPYGNLAHLPVGLVNLDAGTRFANERIDLGQELEKSLLEKKNFDFKIYPSAQAARSAVDRGEVYFAVIIPPGFSTQALQGRGEHPANLVLVSAEGNSYFASTIGKRFAITLSDSVNATLEEKRWIAVLHTSSGLAQLKQALGELRGGASQLLAGASALHSGSQALAQGIAAASNGAAQLHQGAQTLSQGVGALTDGMNRLSNGIRTVVGRLPSEAQLDQLDSGSQHLADGASRLSHGLHELEGGSAQLASGSAQLKDGLGQLAQGSVMLAEKSQELSRGLAKLDALKLGGPNSPLSKGIAEAYTGSLALHQGAAAIAEKTAQAASGATSLNAGATRLSQGMSEADTASRELAAGAQQLGQGVQALVSGTRQLNSGMQSMAARLPGEGDLVRLSNGAQELSQKSGELSQGLNKLAAGSQQLSAGSGKLESGAERLSRGIELVYQKIPASSPLSGDARGLATSVVPRNENLHPVPNNGLATAPLFAGFSLWMGVLILSMFFNYSHLPETARGESQLAKVLVKLAPAALIAVAQALATGGIIAFLMRGAVANRFGFFLVLLLGALAFMAVAGAIMLLLGGAGRALVSLLLILQFVSAGGNFPIELSPPFFRLIHPWLPVTHLLEAMRATLFGSYAGDWFHPALTLLAFMVGGLVLATLAGRRWVYVKDEEYRLEPALLS
>NC_014213.1|WP_049777932.1|113170_113617_+|MarR-family-transcriptional-regulator
MAEPEIKAELPLPAELLPYLGFVLSKATASLHGWVNAELAGLRLDFKQVGFLALLYLQGPQSQIELGRKLRIDRTTVVGMVDDLEAKGYLERQPNPHDRRAYRLVLTPSGRRAIEQAEKIVLRTQEEFLSPLQPGERETLLALLRRLI
>NC_014213.1|WP_013156567.1|125888_127151_+|IS256-family-transposase
MGKRTKVAASPIGEHLEARSSSPTWETLRDWLRGKIRELMQGLLEEEVTEFLGRARYERRAAVDACGYRNGYGKPRKLTTSMGTIEVRRPRVRGVEERFESRILPLFARRTREVSELLPELYLHGLAEGDFDLALRGLLGEEAALSARTVARLKERWQAEWEAWRTQRLDDRAVVYLWVDGVYVKAGLERERAALLVAIAALSDGRKVVVAVVPGYRESVESWSEVLRDLRERGMNAPRLVIGDGHLGIWGALRNVWPEADEQRCWNHKVLNVLEQLPRHQQAVAKPMLGAIAYAPTRAEAERKGKEFEAWCHRHGYGKAAQTLGRDWERMVTFYRYPKEHWRHLRTTNVIESPFAALRLRTDAAKRFKKVERATAVIWKMLMVAQKRFRRLNAPELLAKVHAGVRYEDGIEVTQEEVAA
>NC_014213.1|WP_148226090.1|128039_128669_+|hypothetical-protein
MRNVPPALKRQVFALYGLTKKAGQDWEVDHLISLELGGSNSVRNLWPQAGFTTPWNYHVKDRLENALHYLVCRGELPISVAQHAIAKNWIESFKAVCGDAAAGCAAFRYGARYPEAFHLTPEAKQKLSALGQVALPEGQTRLDTPPPPANTPQSARPNPDGSCPAEAPIKGSKTRVYHLPSDPYYAATHAVACFPSEEAARSAGYRSSR
>NC_014213.1|WP_013159664.1|128744_129023_+|hypothetical-protein
MKIRIAGIEVEYSAFGEGLEALSDPPTRQEETALAALFAAITAQELTPQKVESYRSLGMAQRGRFLLRSTDPAGHPKEHYGRWVKGKALLEG
>NC_014213.1|WP_013159665.1|129053_130448_-|S8-family-serine-peptidase
MPLTRGGWALLLGLVFSACNSVAPVPAPSGFSPCLLSPSTQARSFAVPQGLGDFLAPHVPGELLALSAGIAPQTLTARVEGTQVQDRLAEGFLRLRVPVGQERAKAEALLAAGARWVQPNYLYFPLYQPNDPLYPASTDPYRLQPFYQKINLESAWDKVGPLRCTPVVAVLDTAFNPSHPDLQANLLPGKNLTPDGLGQSDLSPGPPPQGSSYMQGDADHGEGVAGLVAATADNGKGIPGVGLNYVKVLPVKVFYWVGSSYSVSSDVLANAIRYAADQNAAVINMSLGSPTPLDPAVQQALTYALSKGALPVAASGNDGTDGLDYPAAYSGVLAAGAARLEGGRADFSNYSSQTKDLVLVAAGNKSPQQLLYSLALGQNYPYYQSLGRYAAWAGTSFAAPQVSGVAALYVAKFTARYGQGPTPDQVRRCLTQTASNGGFYDPQTGYGLLQADRVLTDTAACFPN
>NC_014213.1|WP_013159666.1|130529_130736_-|twin-arginine-translocase-TatA/TatE-family-subunit
MLAGQDLVVVLLIALLLLGPKQLPGLARGLGQSVREFKKGAEGLLDEDKPVAPEPPKPAATEQDKAKP
>NC_014213.1|WP_013159667.1|130751_130973_-|hypothetical-protein
MAAHKGAEHHHKAAEHHEQAAKHHHAAAEHHEKGEHEQAAHHADTAYAHHKHAEEHAAQAAKHDAEHHAPKPH
>NC_014213.1|WP_013159668.1|131120_132596_-|DUF2867-domain-containing-protein
MRILVTGATGYVGGRLVPRLLERGHTVRVLVRDPSRLQGRPWLSQVEVVQGSLEASPSQHPDHASSLDRALEGVDVAYYLVHAMLAGGDFPQLESGQAETFAQSAHRAGVGRVIYLGGLQPKGVPPSPHLASRAKVGETLRAWVPTTEFRAGPIIGSGSASFEMVRYLTERLPIMVAPRWVLNLVSPIAIRDVLSYLLLALDREPLGVVEIGSAPLTFRAMMETYAAVRGLKRLILPLPVLAPHLAALWVGLVTPIPNRLALPLVEGILHPLVADTRRAQELFPQIAPIPYRTAVELALERIALGEVETRWSGALLAGPSYALEDREGIIREVRRVPVAAPPEALFRSFASLGGEQGWRVWDWAWALRGLLDRLLGGPGLRRGRRHPSELLPGEAVDFWRVEEVRPFELLRLRAEMRLPGRAWLEWRALPEEGGSSLVQTAYFEPKGLMGFLYWWGLYPIHRRIFSDLAQAIAREAVGAAATQMGDLESLR
>NC_014213.1|WP_013159669.1|132748_133825_+|ABC-transporter-substrate-binding-protein
MQRRDLIKKAGAGLAASLSYSALAQATPQVRWRMVSSYPRSLDTLYGGAEDLAKRVAELTEGRFQIRVYQAGEIVPGGQVLDAVQAGTVEAGHTYGPFYVGKNPALAFDGGVPFGMTYRQHNAWMYFGGGLELLRSLYADYGVLQFPGGNTGTQMGGWFRKEVRSLADLKGLRMRIPGLGGLVMGRLGVVPQTLAAGDIYPALERGAIDATEFSGPYDDEKLGFYKVARYYYYPSFWEPSAQLSFLVSQREWQRLPKEFQEAFQVAATEVNLTMMAKYDAQNPLALQRLLKGGVLLRKWTVEIMRKAQEEAKALYEEQAAKDATYREIYTSYRKFLELEYRWFSVAELGFEQFAFPGV
>NC_014213.1|WP_013159670.1|134196_134868_-|diphthine--ammonia-ligase
MDPRRFVASWSGGKDSCYAVMQAQRRGLEPAVLLNVLNEKGRISRAHGIPRPVLEQQARALGVPLVAFPSSWSEYERRFVGALEQVRLEHGVTHAVFGDIDFEPHREWEEKVCARVGLEPVLPLWKEDRAALVRRMVAEGLEAVIVSCNPHLGPGFLGRTLSAETVAELEAAGADPCGENGEYHTLVLNCPLFAQRLEVGFGDKRLHGEYWFLELLPVAGAAG
>NC_014213.1|WP_013159671.1|134884_136033_-|hypothetical-protein
MWKIAVLALTLCAFALSQKTAMQRPDAPPLAAPGAHAVGVRTLQLTDPARARGLTVEVWYPARRAAGAAQPAVYKGVVGSVEFDLPGQALRDAAPEAGKFPLLVYSHGQPGSRYQSAYLMEHLASRGFVVAAIDHTGSLYRDLTQPAYVTSLVDRPLDILFVLGQVPKSLPSADGDTVGLIGYSYGGYSVLGAAGVGIERAGLEQYCQQAGNEGPCFLLPFLAQVEPQRGAQVVRPDPRVKAVFVIAPYGAPWYYGSLPRLEVPLFVAVGEEDDVATYARDGLEVYRRAGSKAKYLLTLAGARHNPFVVCPPEVRANPEDFERCWEPVWDKERLFDLARHFTAAFFQHHLKGEAQAGQYLEPSLPGFRPRAKVGIRLAAFAQ

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Crispr_ID: NC_014213_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014213_2

127195-127518

Orphan

I-C,III-B

Consensus_repeat	Method
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	PILER-CR
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	CRISPRCasFinder
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	CRT

4 spacers

The CRISPR arrays of NC_014213_2

>merge|NC_014213|2|127195-127518|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAACTCGAGTACGCGGGGATCGTGACCAACATCGGCCCGTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAACATTGTTTTATACAGGCCAGTAGGGTAAACGCAAAGGTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAACACTAGTTTAAATACTTTCTTTAATGTTTAAAAATAGTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAACTCAGCGGTTTGCAAACAGGCTGCGGTGTGGGTTCAGTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC

>NC_014213|2|2|127195-127518|PILER-CR
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	TCGAGTACGCGGGGATCGTGACCAACATCGGCCC
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	ATTGTTTTATACAGGCCAGTAGGGTAAACGCAAAG
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	ACTAGTTTAAATACTTTCTTTAATGTTTAAAAATA
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	TCAGCGGTTTGCAAACAGGCTGCGGTGTGGGTTCA
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC

>NC_014213|2|2|127195-127518|CRISPRCasFinder
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	TCGAGTACGCGGGGATCGTGACCAACATCGGCCC
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	ATTGTTTTATACAGGCCAGTAGGGTAAACGCAAAG
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	ACTAGTTTAAATACTTTCTTTAATGTTTAAAAATA
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	TCAGCGGTTTGCAAACAGGCTGCGGTGTGGGTTCA
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC

>NC_014213|2|2|127195-127518|CRT
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	TCGAGTACGCGGGGATCGTGACCAACATCGGCCC
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	ATTGTTTTATACAGGCCAGTAGGGTAAACGCAAAG
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	ACTAGTTTAAATACTTTCTTTAATGTTTAAAAATA
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC	TCAGCGGTTTGCAAACAGGCTGCGGTGTGGGTTCA
GTTTCAATCCTCACTCGAGCTTTCGCCCGAGTGCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014213.1\|WP_013159665.1\|129053_130448_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173810
NC_014213.1\|WP_013159668.1\|131120_132596_-\|DUF2867-domain-containing-protein	unknown	unknown	gnl\|CDD\|187556
NC_014213.1\|WP_013156567.1\|125888_127151_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NC_014213.1\|WP_013159669.1\|132748_133825_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270400
NC_014213.1\|WP_013159667.1\|130751_130973_-\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_013159659.1\|121203_122046_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226616
NC_014213.1\|WP_013159661.1\|122800_123850_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NC_014213.1\|WP_148226099.1\|117797_118724_-\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_169307903.1\|117199_117529_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350249
NC_014213.1\|WP_013159653.1\|113654_115856_+\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NC_014213.1\|WP_013159666.1\|130529_130736_-\|twin-arginine-translocase-TatA/TatE-family-subunit	unknown	unknown	gnl\|CDD\|237837
NC_014213.1\|WP_013159660.1\|122042_122801_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224098
NC_014213.1\|WP_013159673.1\|136523_137891_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366307
NC_014213.1\|WP_013159671.1\|134884_136033_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226651
NC_014213.1\|WP_013159657.1\|118943_120029_+\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_014213.1\|WP_148226090.1\|128039_128669_+\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_013159664.1\|128744_129023_+\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_013159658.1\|120120_121191_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270267
NC_014213.1\|WP_013159654.1\|115942_117013_+\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|239584
NC_014213.1\|WP_013159670.1\|134196_134868_-\|diphthine--ammonia-ligase	unknown	unknown	gnl\|CDD\|238952

Protein	Function_ID	Function_description	E-value
NC_014213.1\|WP_013159665.1\|129053_130448_-\|S8-family-serine-peptidase	gnl\|CDD\|173810	cd07484, Peptidases_S8_Thermitase_like, Peptidase S8 family domain in Thermitase-like proteins. Thermitase is a non-specific, trypsin-related serine protease with a very high specific activity. It contains a subtilisin like domain. The tertiary structure of thermitase is similar to that of subtilisin BPN'. It contains a Asp/His/Ser catalytic triad. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) clan include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53 the it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	6.55811e-55
NC_014213.1\|WP_013159668.1\|131120_132596_-\|DUF2867-domain-containing-protein	gnl\|CDD\|187556	cd05245, SDR_a2, atypical (a) SDRs, subgroup 2. This subgroup contains atypical SDRs, one member is identified as Escherichia coli protein ybjT, function unknown. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that generally matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.7064e-124
NC_014213.1\|WP_013156567.1\|125888_127151_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	4.31519e-57
NC_014213.1\|WP_013159669.1\|132748_133825_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270400	cd13682, PBP2_TRAP_alpha-ketoacid, Substrate-binding component of an alpha-keto acid binding Tripartite ATP-independent Periplasmic transporter and related proteins; contains the type 2 periplasmic-binding protein fold. This subgroup includes TRAP transporters that bind to ketoacids such as pyruvate and alpha-ketobutyrate, xylulose, and other unknown ligands. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.08866e-176
NC_014213.1\|WP_013159659.1\|121203_122046_+\|ABC-transporter-permease-subunit	gnl\|CDD\|226616	COG4132, COG4132, ABC-type uncharacterized transport system, permease component [General function prediction only].	6.63732e-71
NC_014213.1\|WP_013159661.1\|122800_123850_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	1.27074e-148
NC_014213.1\|WP_169307903.1\|117199_117529_+\|hypothetical-protein	gnl\|CDD\|350249	cd18682, PIN_VapC-like, Uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.0621e-26
NC_014213.1\|WP_013159653.1\|113654_115856_+\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	2.3929e-75
NC_014213.1\|WP_013159666.1\|130529_130736_-\|twin-arginine-translocase-TatA/TatE-family-subunit	gnl\|CDD\|237837	PRK14861, tatA, twin arginine translocase protein A; Provisional.	2.82518e-11
NC_014213.1\|WP_013159660.1\|122042_122801_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	2.08194e-33
NC_014213.1\|WP_013159673.1\|136523_137891_-\|hypothetical-protein	gnl\|CDD\|366307	pfam00791, ZU5, ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.	0.0032877
NC_014213.1\|WP_013159671.1\|134884_136033_-\|hypothetical-protein	gnl\|CDD\|226651	COG4188, COG4188, Predicted dienelactone hydrolase [General function prediction only].	2.52754e-22
NC_014213.1\|WP_013159657.1\|118943_120029_+\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	8.70275e-18
NC_014213.1\|WP_013159658.1\|120120_121191_+\|extracellular-solute-binding-protein	gnl\|CDD\|270267	cd13549, PBP2_Fbp_like_3, Substrate binding domain of an uncharacterized ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. This periplasmic domain (Fbp) has high affinity for ferric iron and serves as the primary receptor for transport. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.10012e-60
NC_014213.1\|WP_013159654.1\|115942_117013_+\|fatty-acid-desaturase	gnl\|CDD\|239584	cd03507, Delta12-FADS-like, The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of organisms including higher plants, green algae, diatoms, nematodes, fungi, and bacteria. The expression of these proteins appears to be temperature dependent: decreases in temperature result in increased levels of fatty acid desaturation within membrane lipids subsequently altering cell membrane fluidity. An important enzyme for the production of polyunsaturates in plants is the oleate delta-12 desaturase (Arabidopsis FAD2) of the endoplasmic reticulum. This enzyme accepts l-acyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate and requires NADH:cytochrome b oxidoreductase, cytochrome b, and oxygen for activity. FAD2 converts oleate(18:1) to linoleate (18:2) and is closely related to oleate 12-hydroxylase which catalyzes the hydroxylation of oleate to ricinoleate. Plastid-bound desaturases (Arabidopsis delta-12 desaturase (FAD6), omega-3 desaturase (FAD8), omega-6 desaturase (FAD6)), as well as, the cyanobacterial thylakoid-bound FADSs require oxygen, ferredoxin, and ferredoxin oxidoreductase for activity. As in higher plants, the cyanobacteria delta-12 (DesA) and omega-3 (DesB) FADSs desaturate oleate (18:1) to linoleate (18:2) and linoleate (18:2) to linolenate (18:3), respectively. Omega-3 (DesB/FAD8) and omega-6 (DesD/FAD6) desaturases catalyze reactions that introduce a double bond between carbons three and four, and carbons six and seven, respectively, from the methyl end of fatty acids. As with other members of this superfamily, this domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain eight histidine residues: HXXXH, HXX(X)HH, and HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homologue, stearoyl CoA desaturase. Mutation of any one of four of these histidines in the Synechocystis delta-12 acyl-lipid desaturase resulted in complete inactivity.	4.35147e-69
NC_014213.1\|WP_013159670.1\|134196_134868_-\|diphthine--ammonia-ligase	gnl\|CDD\|238952	cd01994, Alpha_ANH_like_IV, This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily of proteins is predicted to bind ATP. This domainhas a strongly conserved motif SGGKD at the N terminus.	2.96931e-63

>NC_014213.1|WP_013156567.1|125888_127151_+|IS256-family-transposase
MGKRTKVAASPIGEHLEARSSSPTWETLRDWLRGKIRELMQGLLEEEVTEFLGRARYERRAAVDACGYRNGYGKPRKLTTSMGTIEVRRPRVRGVEERFESRILPLFARRTREVSELLPELYLHGLAEGDFDLALRGLLGEEAALSARTVARLKERWQAEWEAWRTQRLDDRAVVYLWVDGVYVKAGLERERAALLVAIAALSDGRKVVVAVVPGYRESVESWSEVLRDLRERGMNAPRLVIGDGHLGIWGALRNVWPEADEQRCWNHKVLNVLEQLPRHQQAVAKPMLGAIAYAPTRAEAERKGKEFEAWCHRHGYGKAAQTLGRDWERMVTFYRYPKEHWRHLRTTNVIESPFAALRLRTDAAKRFKKVERATAVIWKMLMVAQKRFRRLNAPELLAKVHAGVRYEDGIEVTQEEVAA
>NC_014213.1|WP_013159661.1|122800_123850_+|ABC-transporter-ATP-binding-protein
MAALRLEGLRRRFGNVEALAAFNLEVASGELVTLLGPSGCGKTTLLRIVAGFEQPDAGQVWLEGEDITKTPPNRRHMGMVFQAYSLFPNMSAEENVRFGLRLRGLSRAEQEQRLSELFRLIGLEDVRKRYPHQLSGGQQQRIALARALAPRPKVLLMDEPLSALDAQVRQTLREEIRRIQQAEKITTLFVTHDQEEALTLSDRVVVMNRGKIEQVGSPREVYLRPASAFVAGFVGVSSVLEGEWLTGNRVRTAAGSLIVAPGEHPVGAKVKVFLRPENLRLAKPGGEGLEGRIEENVFMGSFVRVRVRLRDGQSLWIDQGLEEAVQWQIGDEVKVDNASSLGHGVVVLG
>NC_014213.1|WP_013159660.1|122042_122801_+|ABC-transporter-permease-subunit
MTRRLLLALFGLYFLLPLLATAIYSLWAGGQRYDLSAYARILGDPQFRSSFTLSFTLAVETVVLSLLLLIPAVFWANLRWPGLRALLEVVSVMPFVVPPIALVGGLTALYKGPAWWIGSPQFLIVGYTVLALPYTYRALDAGMRAIDLKTLSEAALSLGSSWLGLLLRVVVPCILPSILSAALLTLAIVMGEFTFANVLLFNTFAVYINYVGQTQGTGAAALSLLSFALTWLAMIAILRSGRQGQPSLGGGR
>NC_014213.1|WP_013159659.1|121203_122046_+|ABC-transporter-permease-subunit
MEWLNRLLFSGPLLLFVGAFLLLPSLQLGYLALSDGHGGLTVRYLEALGQPQYRVAFQNSILLSGTTAVLGGILGTMLAFLTSAGRGWLAEAVTAFNGVAANFAGVPLAFAFIATLGTTGLLTQFLRQALGLDLYGLGFSLFSYWGLVVVYLYFQIPLMFLVMAPVVSGLRREWREAAYGLGATPFQYWTRVVFPLILPATLAGTILLFGNAFSAYATPYALTSGVLPLVPLQIGSALQGNVSADPQQGAALALGMVALMLASLGLYLALARRHSRWRNQ
>NC_014213.1|WP_013159658.1|120120_121191_+|extracellular-solute-binding-protein
MRYKRALTRREVLRLGGVATGSLTLGLLMKGQAQSKTLNTIALPPDWANYGEIMATFTKKYGITINNASPNASSAEELQALRSLKGQSRAPDVVDVGPSFAIQGKQEGLFAPYKVSTWDSIPANMKDPDGYWYGDYFGVISFGVNASVVKKVPKTWADLKDPAYKGQIALNGSPLTAGAAFAGVWAAALANGGSLDDITPGIDFFAQLKKMGNYIPVDATPATVQTGQTPIVVDWDYLNLGYSKEFAGKLDWRVSVPEDGVYGSYYCQAISAFAPNPASARQWMEFLYSDEGQLLFLKGYAHPVRFNDMLRRKVIPTELLAKLPPSEPYTKVRFATQEQLKKAQETLKAQWAAKVG
>NC_014213.1|WP_013159657.1|118943_120029_+|transposase
MQFTTVGREIWRGARQAQRLAEANASDPEVQERLRKLRLVKALRESKKSWKEIQDLVGISRATYHRWQKALKEKGLAGLKPRSRRPKHLRTKVHWTPGLLIRIETLRKENPTWGRWSIWLTLRKEGFQMSERTVGRILAYLEKHRRIESVAGYLARTQRGKLKRRVNRPYAKRKPRGYEARAPGDLVQVDTLTLTLGPGSMVKHFSAIDLHSRFVLAEVHSRATAKLSEGFLSLLLARAPFPIRAIQVDGGSEFMAEFEEACCALGIALFVLPPRSPKLNGHVERMQRTFKEEFYTRPLPTPLSELQAELDTYLDYYNRRRPHMALGGLAPLEFLAKMQEESVPQRVSNVLTDYRMLAVLP
>NC_014213.1|WP_148226099.1|117797_118724_-|hypothetical-protein
MVLIAVMLATSFALAERFSFVAIGDMPYGEMAPFENLVKAINAARPSFTVHVGDIKSGSSPCTDAYMLKIRDLFNTFSAPLVYTPGDNEWTDCHREKAGKYDPIERLAFVRQTFFTNNQSFGAQKMTLEQQSADPKFAKFVENERWSLGGVVFATLHVVGSNNNLQRNQAAVNEYIERNAANLSWLESTFAKASSEGAKAVVLFWQADPMFEETSEDKRSGFTEILALLKSKVKAFGRPVLLVHGDSHTFIVDQPWYSESDASNIGNFYRLEVYGSARVHAVQVEVDTDTPGIFSFRPLMVRENLPKN
>NC_014213.1|WP_169307903.1|117199_117529_+|hypothetical-protein
MEDALEHGVLSAVTFTEVLGKLVGKGVPADQAEADLDELGLEVVDYDRELAKVAAYFYARRNPYNLSLGACAVLALGEHLGLPILTGEQAWAKLPGLRVKVRLIRKVMP
>NC_014213.1|WP_013159654.1|115942_117013_+|fatty-acid-desaturase
MDTSKLQPKDWIPLIKPYAKPDLRRSLHQVGNTLLPLLLLFYLAYLALSVSVVLTLALDFVAALFVVRLFILQHDAGHGSFFPKKWANDLLGFFAGILTLVPYHHWQLSHARHHATSGNLDKRGVGDIYTLTLTEYLRASPWERLKYRIYRNPLVMFLVGPIYTFMLSYRLPLGFGADKPLVRNSVALTNLFLVLLWVGIALGFGLKTLLWVYLPIQYFAGMVGIFLFYVQHQFEDAYWEHDPRWEHLKSAMEGSTYLKLPKPLQWLTGNIGFHHIHHLSPKIPNYNLERVQQEVDLVQVAPTVTLRDAFAIAFADLHLHDEESRKLMGFREAGRRIREARRAQAKSGYPGYQSAP
>NC_014213.1|WP_013159653.1|113654_115856_+|YhgE/Pip-domain-containing-protein
MPPSFQTSSSPTAKLGFWSFLARELVHVGSNRQVVLLLLGIALLPALFALIQITSAWDPYGNLAHLPVGLVNLDAGTRFANERIDLGQELEKSLLEKKNFDFKIYPSAQAARSAVDRGEVYFAVIIPPGFSTQALQGRGEHPANLVLVSAEGNSYFASTIGKRFAITLSDSVNATLEEKRWIAVLHTSSGLAQLKQALGELRGGASQLLAGASALHSGSQALAQGIAAASNGAAQLHQGAQTLSQGVGALTDGMNRLSNGIRTVVGRLPSEAQLDQLDSGSQHLADGASRLSHGLHELEGGSAQLASGSAQLKDGLGQLAQGSVMLAEKSQELSRGLAKLDALKLGGPNSPLSKGIAEAYTGSLALHQGAAAIAEKTAQAASGATSLNAGATRLSQGMSEADTASRELAAGAQQLGQGVQALVSGTRQLNSGMQSMAARLPGEGDLVRLSNGAQELSQKSGELSQGLNKLAAGSQQLSAGSGKLESGAERLSRGIELVYQKIPASSPLSGDARGLATSVVPRNENLHPVPNNGLATAPLFAGFSLWMGVLILSMFFNYSHLPETARGESQLAKVLVKLAPAALIAVAQALATGGIIAFLMRGAVANRFGFFLVLLLGALAFMAVAGAIMLLLGGAGRALVSLLLILQFVSAGGNFPIELSPPFFRLIHPWLPVTHLLEAMRATLFGSYAGDWFHPALTLLAFMVGGLVLATLAGRRWVYVKDEEYRLEPALLS
>NC_014213.1|WP_148226090.1|128039_128669_+|hypothetical-protein
MRNVPPALKRQVFALYGLTKKAGQDWEVDHLISLELGGSNSVRNLWPQAGFTTPWNYHVKDRLENALHYLVCRGELPISVAQHAIAKNWIESFKAVCGDAAAGCAAFRYGARYPEAFHLTPEAKQKLSALGQVALPEGQTRLDTPPPPANTPQSARPNPDGSCPAEAPIKGSKTRVYHLPSDPYYAATHAVACFPSEEAARSAGYRSSR
>NC_014213.1|WP_013159664.1|128744_129023_+|hypothetical-protein
MKIRIAGIEVEYSAFGEGLEALSDPPTRQEETALAALFAAITAQELTPQKVESYRSLGMAQRGRFLLRSTDPAGHPKEHYGRWVKGKALLEG
>NC_014213.1|WP_013159665.1|129053_130448_-|S8-family-serine-peptidase
MPLTRGGWALLLGLVFSACNSVAPVPAPSGFSPCLLSPSTQARSFAVPQGLGDFLAPHVPGELLALSAGIAPQTLTARVEGTQVQDRLAEGFLRLRVPVGQERAKAEALLAAGARWVQPNYLYFPLYQPNDPLYPASTDPYRLQPFYQKINLESAWDKVGPLRCTPVVAVLDTAFNPSHPDLQANLLPGKNLTPDGLGQSDLSPGPPPQGSSYMQGDADHGEGVAGLVAATADNGKGIPGVGLNYVKVLPVKVFYWVGSSYSVSSDVLANAIRYAADQNAAVINMSLGSPTPLDPAVQQALTYALSKGALPVAASGNDGTDGLDYPAAYSGVLAAGAARLEGGRADFSNYSSQTKDLVLVAAGNKSPQQLLYSLALGQNYPYYQSLGRYAAWAGTSFAAPQVSGVAALYVAKFTARYGQGPTPDQVRRCLTQTASNGGFYDPQTGYGLLQADRVLTDTAACFPN
>NC_014213.1|WP_013159666.1|130529_130736_-|twin-arginine-translocase-TatA/TatE-family-subunit
MLAGQDLVVVLLIALLLLGPKQLPGLARGLGQSVREFKKGAEGLLDEDKPVAPEPPKPAATEQDKAKP
>NC_014213.1|WP_013159667.1|130751_130973_-|hypothetical-protein
MAAHKGAEHHHKAAEHHEQAAKHHHAAAEHHEKGEHEQAAHHADTAYAHHKHAEEHAAQAAKHDAEHHAPKPH
>NC_014213.1|WP_013159668.1|131120_132596_-|DUF2867-domain-containing-protein
MRILVTGATGYVGGRLVPRLLERGHTVRVLVRDPSRLQGRPWLSQVEVVQGSLEASPSQHPDHASSLDRALEGVDVAYYLVHAMLAGGDFPQLESGQAETFAQSAHRAGVGRVIYLGGLQPKGVPPSPHLASRAKVGETLRAWVPTTEFRAGPIIGSGSASFEMVRYLTERLPIMVAPRWVLNLVSPIAIRDVLSYLLLALDREPLGVVEIGSAPLTFRAMMETYAAVRGLKRLILPLPVLAPHLAALWVGLVTPIPNRLALPLVEGILHPLVADTRRAQELFPQIAPIPYRTAVELALERIALGEVETRWSGALLAGPSYALEDREGIIREVRRVPVAAPPEALFRSFASLGGEQGWRVWDWAWALRGLLDRLLGGPGLRRGRRHPSELLPGEAVDFWRVEEVRPFELLRLRAEMRLPGRAWLEWRALPEEGGSSLVQTAYFEPKGLMGFLYWWGLYPIHRRIFSDLAQAIAREAVGAAATQMGDLESLR
>NC_014213.1|WP_013159669.1|132748_133825_+|ABC-transporter-substrate-binding-protein
MQRRDLIKKAGAGLAASLSYSALAQATPQVRWRMVSSYPRSLDTLYGGAEDLAKRVAELTEGRFQIRVYQAGEIVPGGQVLDAVQAGTVEAGHTYGPFYVGKNPALAFDGGVPFGMTYRQHNAWMYFGGGLELLRSLYADYGVLQFPGGNTGTQMGGWFRKEVRSLADLKGLRMRIPGLGGLVMGRLGVVPQTLAAGDIYPALERGAIDATEFSGPYDDEKLGFYKVARYYYYPSFWEPSAQLSFLVSQREWQRLPKEFQEAFQVAATEVNLTMMAKYDAQNPLALQRLLKGGVLLRKWTVEIMRKAQEEAKALYEEQAAKDATYREIYTSYRKFLELEYRWFSVAELGFEQFAFPGV
>NC_014213.1|WP_013159670.1|134196_134868_-|diphthine--ammonia-ligase
MDPRRFVASWSGGKDSCYAVMQAQRRGLEPAVLLNVLNEKGRISRAHGIPRPVLEQQARALGVPLVAFPSSWSEYERRFVGALEQVRLEHGVTHAVFGDIDFEPHREWEEKVCARVGLEPVLPLWKEDRAALVRRMVAEGLEAVIVSCNPHLGPGFLGRTLSAETVAELEAAGADPCGENGEYHTLVLNCPLFAQRLEVGFGDKRLHGEYWFLELLPVAGAAG
>NC_014213.1|WP_013159671.1|134884_136033_-|hypothetical-protein
MWKIAVLALTLCAFALSQKTAMQRPDAPPLAAPGAHAVGVRTLQLTDPARARGLTVEVWYPARRAAGAAQPAVYKGVVGSVEFDLPGQALRDAAPEAGKFPLLVYSHGQPGSRYQSAYLMEHLASRGFVVAAIDHTGSLYRDLTQPAYVTSLVDRPLDILFVLGQVPKSLPSADGDTVGLIGYSYGGYSVLGAAGVGIERAGLEQYCQQAGNEGPCFLLPFLAQVEPQRGAQVVRPDPRVKAVFVIAPYGAPWYYGSLPRLEVPLFVAVGEEDDVATYARDGLEVYRRAGSKAKYLLTLAGARHNPFVVCPPEVRANPEDFERCWEPVWDKERLFDLARHFTAAFFQHHLKGEAQAGQYLEPSLPGFRPRAKVGIRLAAFAQ
>NC_014213.1|WP_013159673.1|136523_137891_-|hypothetical-protein
MRKRVYLAAALLLGLLGACSGGSRPQGPEPAPRGTPTGDPAVATIGPEGGRLASADGVLTLEVPPGAVEAPTQFGIQPITNTAGGLASGYRLSPEGRTFPKPVKLTFRYTEEELGEASPEGLGLAFQDEKGVWWAHLGTELDKAGRTLSVQTRHFSDWVRKTFWVFIPEEARLKVGESLGLMVIACVLEQYAGPVPEFDEEELLAPLIPKDRESCGPSVRTGSWAVNGVPGGNGTYGTVIPLQPSSRATYTAPAKVPSPNPVTVTADMTWEERKVTKRFTSRITVQDALVQVHVVGSFSYVGHPIAVGVIADVQDRFEADLGLSTEPGGSGSYMDNIQNTLSTEANARPEAGLEQGICSFQLGGDYEHLSVSSWRFMGATDKLYYFTLEGSVTVPPVTLYLRTDKGCLASTFPGYSWDRGGTAFAVDLSCLQKPGDAYTATDVFNSGWEFRFERR

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Crispr_ID: NC_014213_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014213_3

318307-319855

Unclear

Consensus_repeat	Method
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CRT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	PILER-CR
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CRISPRCasFinder

21 spacers

cas2,cas1,cas4,WYL,cas3,cas8a8,cas7,cas5,cas6

The CRISPR arrays of NC_014213_3

>merge|NC_014213|3|318307-319855|CRT,PILER-CR,CRISPRCasFinder
CAGATACCTGACCTCGGAGTATTTACAGCTTATACCCCGGCTCATCAAATTTCCGACTCCGCTAGTTGGCCAGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCCCGGCACTTCCTGAGGTTTCCGTGTGAGCTATTTTGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCGCCCTACGAGACGGGCAAGCCCGCGCCCCAGGGCGAGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCCCTGAGGAAACCAGACGGACGCAGCCTTTCAAGATTGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCGGAGATCCCCGCTGCCTTGAGAGCGAGGGCGGTGTCGAGGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCGCGCTTGAACCGGGCGAGCAGCTCCTCCAAGGTCGTGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCCGTGAGCGGTCACCCGGATGCGCTCTCCCCGCTCAGCGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCGGGAGCCCCGACGGCTCGGCGGCCACCCACCGGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCCGTGAGCGGTCACCCGGATGCGCTCTCCCCGCTCAGCGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCACCACCACCGTGCCGCCCGCTTCCCATAGGTAGGCGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCGGGGCGGCTCCGCCGCCAGGGAGGGGGCGATATGGCGGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCTTATAAAACCATCCCTGGGCGTCTCTGGCACGCTTGGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCTTGCCTCCCACCATGGGTGGTCTGCTGGAAGCACCGGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCCTTCAGGATTTCGTGAAGGCCCTCGAGGGTTACGGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCGGCAGGCAGAGGGTGAGCATGCGGCCTAGGTATCCCGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCCGTTGAGGGCCCGCAAGGGCTGGCGGGGATGCATCTGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCACCTGTACTCGTTCGACTGTATTGCTCCCAGCTAGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCTGAGCTGTACCAGGCGGCACGCCCAATGCTGGCGGTGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCACCTCGCCCGGTCTCCCCCTCTCGCTAGGGGCATTTTGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCGCAAGTCCCATCGAACGGGGGGAGAAACTTCAACAAGGTTTCAATCTCCTACGGAGTATTTACAGCTTATACCTCCAATCGAGCCCCAGTCATCACCGGCACTCCCAACAAGGTTTCAATCTCCTACGGAGTATTTACAGCTTATACC

>NC_014213|3|3|318307-319855|CRT
CAGATACCTGACCTCGGAGTATTTACAGCTTATACC	CCGGCTCATCAAATTTCCGACTCCGCTAGTTGGCCA
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CCGGCACTTCCTGAGGTTTCCGTGTGAGCTATTTT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GCCCTACGAGACGGGCAAGCCCGCGCCCCAGGGCGA
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CCTGAGGAAACCAGACGGACGCAGCCTTTCAAGATT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGAGATCCCCGCTGCCTTGAGAGCGAGGGCGGTGTCGAG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GCGCTTGAACCGGGCGAGCAGCTCCTCCAAGGTCGT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CGTGAGCGGTCACCCGGATGCGCTCTCCCCGCTCAGC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGGAGCCCCGACGGCTCGGCGGCCACCCACCG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CGTGAGCGGTCACCCGGATGCGCTCTCCCCGCTCAGC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	ACCACCACCGTGCCGCCCGCTTCCCATAGGTAGGC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGGGCGGCTCCGCCGCCAGGGAGGGGGCGATATGGCG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TTATAAAACCATCCCTGGGCGTCTCTGGCACGCTTG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TTGCCTCCCACCATGGGTGGTCTGCTGGAAGCACCG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CTTCAGGATTTCGTGAAGGCCCTCGAGGGTTACG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGCAGGCAGAGGGTGAGCATGCGGCCTAGGTATCCC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CGTTGAGGGCCCGCAAGGGCTGGCGGGGATGCATCT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	ACCTGTACTCGTTCGACTGTATTGCTCCCAGCTA
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TGAGCTGTACCAGGCGGCACGCCCAATGCTGGCGGT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	ACCTCGCCCGGTCTCCCCCTCTCGCTAGGGGCATTTT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GCAAGTCCCATCGAACGGGGGGAGAAACTTCAACAAG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TCCAATCGAGCCCCAGTCATCACCGGCACTCCCAACAAG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC

>NC_014213|3|3|318379-319855|PILER-CR
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CCGGCACTTCCTGAGGTTTCCGTGTGAGCTATTTT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GCCCTACGAGACGGGCAAGCCCGCGCCCCAGGGCGA
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CCTGAGGAAACCAGACGGACGCAGCCTTTCAAGATT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGAGATCCCCGCTGCCTTGAGAGCGAGGGCGGTGTCGAG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GCGCTTGAACCGGGCGAGCAGCTCCTCCAAGGTCGT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CGTGAGCGGTCACCCGGATGCGCTCTCCCCGCTCAGC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGGAGCCCCGACGGCTCGGCGGCCACCCACCG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CGTGAGCGGTCACCCGGATGCGCTCTCCCCGCTCAGC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	ACCACCACCGTGCCGCCCGCTTCCCATAGGTAGGC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGGGCGGCTCCGCCGCCAGGGAGGGGGCGATATGGCG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TTATAAAACCATCCCTGGGCGTCTCTGGCACGCTTG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TTGCCTCCCACCATGGGTGGTCTGCTGGAAGCACCG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CTTCAGGATTTCGTGAAGGCCCTCGAGGGTTACG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGCAGGCAGAGGGTGAGCATGCGGCCTAGGTATCCC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CGTTGAGGGCCCGCAAGGGCTGGCGGGGATGCATCT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	ACCTGTACTCGTTCGACTGTATTGCTCCCAGCTA
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TGAGCTGTACCAGGCGGCACGCCCAATGCTGGCGGT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	ACCTCGCCCGGTCTCCCCCTCTCGCTAGGGGCATTTT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GCAAGTCCCATCGAACGGGGGGAGAAACTTCAACAAG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TCCAATCGAGCCCCAGTCATCACCGGCACTCCCAACAAG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC

>NC_014213|3|3|318379-319855|CRISPRCasFinder
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CCGGCACTTCCTGAGGTTTCCGTGTGAGCTATTTT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GCCCTACGAGACGGGCAAGCCCGCGCCCCAGGGCGA
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CCTGAGGAAACCAGACGGACGCAGCCTTTCAAGATT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGAGATCCCCGCTGCCTTGAGAGCGAGGGCGGTGTCGAG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GCGCTTGAACCGGGCGAGCAGCTCCTCCAAGGTCGT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CGTGAGCGGTCACCCGGATGCGCTCTCCCCGCTCAGC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGGAGCCCCGACGGCTCGGCGGCCACCCACCG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CGTGAGCGGTCACCCGGATGCGCTCTCCCCGCTCAGC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	ACCACCACCGTGCCGCCCGCTTCCCATAGGTAGGC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGGGCGGCTCCGCCGCCAGGGAGGGGGCGATATGGCG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TTATAAAACCATCCCTGGGCGTCTCTGGCACGCTTG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TTGCCTCCCACCATGGGTGGTCTGCTGGAAGCACCG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CTTCAGGATTTCGTGAAGGCCCTCGAGGGTTACG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GGCAGGCAGAGGGTGAGCATGCGGCCTAGGTATCCC
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	CGTTGAGGGCCCGCAAGGGCTGGCGGGGATGCATCT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	ACCTGTACTCGTTCGACTGTATTGCTCCCAGCTA
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TGAGCTGTACCAGGCGGCACGCCCAATGCTGGCGGT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	ACCTCGCCCGGTCTCCCCCTCTCGCTAGGGGCATTTT
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	GCAAGTCCCATCGAACGGGGGGAGAAACTTCAACAAG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC	TCCAATCGAGCCCCAGTCATCACCGGCACTCCCAACAAG
GTTTCAATCTCCTACGGAGTATTTACAGCTTATACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014213.1\|WP_013159782.1\|316197_316371_+\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_013159785.1\|320098_320380_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_014213.1\|WP_013159790.1\|325867_327259_+\|hypothetical-protein	cas8a8	mkCas0180_cas8a8_CAS-I-A	unknown
NC_014213.1\|WP_041653780.1\|316980_317517_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226415
NC_014213.1\|WP_041653779.1\|316465_317071_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|198111
NC_014213.1\|WP_013159778.1\|311744_313760_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|227319
NC_014213.1\|WP_013159779.1\|314104_314410_-\|helix-hairpin-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378965
NC_014213.1\|WP_013159789.1\|323324_325877_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_014213.1\|WP_013159786.1\|320389_321370_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|376633
NC_014213.1\|WP_013159781.1\|315084_316179_+\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_014213.1\|WP_013159791.1\|327255_328263_+\|DevR-family-CRISPR-associated-autoregulator	cas7	pfam01905_cas7_CAS-I	gnl\|CDD\|376656
NC_014213.1\|WP_013159788.1\|322120_323089_+\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_014213.1\|WP_013159784.1\|317899_318181_-\|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	unknown	unknown	gnl\|CDD\|226603
NC_014213.1\|WP_013159783.1\|317544_317919_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350220
NC_014213.1\|WP_013159787.1\|321369_321942_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NC_014213.1\|WP_013159780.1\|314523_314913_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372287
NC_014213.1\|WP_148225922.1\|330969_332093_-\|IS3-like-element-ISMesi1-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_014213.1\|WP_013159793.1\|329020_329827_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_014213.1\|WP_013159777.1\|310401_311715_-\|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NC_014213.1\|WP_013159792.1\|328271_329021_+\|hypothetical-protein	cas5	cls000048_cas5_CAS-I-A	unknown

Protein	Function_ID	Function_description	E-value
NC_014213.1\|WP_013159778.1\|311744_313760_-\|ABC-transporter-permease-subunit	gnl\|CDD\|227319	COG4986, COG4986, ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism].	1.10635e-72
NC_014213.1\|WP_013159785.1\|320098_320380_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	7.19321e-22
NC_014213.1\|WP_041653780.1\|316980_317517_+\|AAA-family-ATPase	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	5.60357e-11
NC_014213.1\|WP_041653779.1\|316465_317071_+\|hypothetical-protein	gnl\|CDD\|198111	smart01043, BTAD, Bacterial transcriptional activator domain. Found in the DNRI/REDD/AFSR family of regulators. This region of AFSR along with the C terminal region is capable of independently directing actinorhodin production. This family contains TPR repeats.	6.84873e-13
NC_014213.1\|WP_013159779.1\|314104_314410_-\|helix-hairpin-helix-domain-containing-protein	gnl\|CDD\|378965	pfam12836, HHH_3, Helix-hairpin-helix motif. The HhH domain is a short DNA-binding domain.	1.56917e-17
NC_014213.1\|WP_013159789.1\|323324_325877_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	3.07775e-51
NC_014213.1\|WP_013159786.1\|320389_321370_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	5.56017e-110
NC_014213.1\|WP_013159781.1\|315084_316179_+\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	1.18015e-17
NC_014213.1\|WP_013159791.1\|327255_328263_+\|DevR-family-CRISPR-associated-autoregulator	gnl\|CDD\|376656	pfam01905, DevR, CRISPR-associated negative auto-regulator DevR/Csa2. This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats. It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation. Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers. This family used to be known as DUF73. DevR appears to be negative auto-regulator within the system.	2.50464e-36
NC_014213.1\|WP_013159788.1\|322120_323089_+\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	5.134e-30
NC_014213.1\|WP_013159784.1\|317899_318181_-\|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	gnl\|CDD\|226603	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning].	6.92494e-09
NC_014213.1\|WP_013159783.1\|317544_317919_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350220	cd09872, PIN_Sll0205-like, VapC-like PIN domain of Sll0205 protein and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Synechocystis sp. (strain PCC 6803) Sll0205 protein and other uncharacterized homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.11131e-51
NC_014213.1\|WP_013159787.1\|321369_321942_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	6.62157e-33
NC_014213.1\|WP_013159780.1\|314523_314913_-\|hypothetical-protein	gnl\|CDD\|372287	pfam12747, DdrB, DdrB-like protein. This family includes the Deinococcus DdrB protein which is a ssDNA binding protein. This family also includes some possibly distantly related cyanobacterial proteins. However, these are not strongly supported. The structure of DdrB is known.	6.36274e-17
NC_014213.1\|WP_148225922.1\|330969_332093_-\|IS3-like-element-ISMesi1-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.07047e-45
NC_014213.1\|WP_013159793.1\|329020_329827_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	4.03885e-18
NC_014213.1\|WP_013159777.1\|310401_311715_-\|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	7.23107e-112

>NC_014213.1|WP_013159784.1|317899_318181_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin
MPKAADWKKKVVNIAEAKAQLSRLIERVERGEVVLIGRYGRVVAKLVPPEAAPKPKRVPGVWKGKVWIAPDFDEPNAEISRMIEESPLEPAAR
>NC_014213.1|WP_013159783.1|317544_317919_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MNLLLDSHIVLWWLSDDERLTRKARRLIERADDVFVSAATTWELAVKASLGKLRMPEGFLEVVEAQGFTHLPITPLHALAVQSLPWHHRDPFDRILLAQALVEGLGLVSVDDALASYGKFVIGV
>NC_014213.1|WP_041653780.1|316980_317517_+|AAA-family-ATPase
MRGARLALVRGEPGVGKTRLLQETFPDSPLIRCREGLERLPFFPLLEYLKPRLDLLPDLGLYRQDLARLLPELAPGQALPPPDPLSGKTRLFEALARALEPLEPLMMDDLQWADEGTLELLVYLGNRGQRIAGAYRTHEVGPALARTLETQRACGTLSPRAHLPPTMIFSPQMYACWA
>NC_014213.1|WP_041653779.1|316465_317071_+|hypothetical-protein
MAEFRAAIGRADWGAALAWHRRPFLEEFPLHDVPAFEEWASLERQALLEAWQKAALRHAEGLQEQGEYPQAARLLGELLRQDPLAEDVLQGYLRAAYLAGEREVALRAYERFAQELWRELELKPMEVTVGLGLRPCAARSRWNSKRRSPSPRFRWRCSGPRIWWAGRANKPGCAGPGWPWCGASPGWARPGSCRRPSPILP
>NC_014213.1|WP_013159782.1|316197_316371_+|hypothetical-protein
MPPRLYLLDEPHVQEEGGCRLELAPARPTYLLVYLACRGEWVSREALAGASGGRGPA
>NC_014213.1|WP_013159781.1|315084_316179_+|transposase
MQFTTVGREIWRGARQAQRLAEANASDPEVQERLRKLRLVKALRESKKSWKEIQDLVGISRATYHRWQKALKEKGLAGLKPRSRRPKHLRTKVHWTPGLLIRIETLRKENPTWGRWSIWLTLRKEGFQMSERTVGRILAYLEKHRRIESVAGYLARTQRGKLKRRVNRPYAKRKPRGYEARAPGDLVQVDTLTLTLGPGSMVKHFSAIDLHSRFVLAEVHSRATAKLSEGFLSLLLARAPFPIRAIQVDGGSEFMAEFEEACCALGIALFVLPPRSPKLNGHVERMQRTFKEEFYTRPLPTPLSELQAELDTYLDYYNRRRPHMALGGLAPLEFLAKMQEESVPQRVSNVLTDYRALTRPGHGD
>NC_014213.1|WP_013159780.1|314523_314913_-|hypothetical-protein
MRLVLQTPLGHTVVLETTPQTWLEDLRTWGAKGFRPAAPPPGGFVLPLECHRCFDWAFLGATAEGEYVQAFGYRWKRRHLPARQGLPEQVKYSRGAWQYEEEGVEGKRQGYVTLIRFEGPGRCGLWCRR
>NC_014213.1|WP_013159779.1|314104_314410_-|helix-hairpin-helix-domain-containing-protein
MRKFTRLVMVALAVVGGSFMALAASGNTAGASKTTMSMKIAPVHINTATLAQLETLPGIGPKLAQEIIKHRPYKNGQELQSKVKGIGPAVWKKIAPYVLFN
>NC_014213.1|WP_013159778.1|311744_313760_-|ABC-transporter-permease-subunit
MRRVFPSPEALRPRAPFSRWDLVVIPGVLVLLALFTLALQGATEPFGPTSPNLTVSLDPAHLPYYGLRTLLRMLAALLLSLVFTFVYATVAAKVPRTERVLIPILDFLQSLPILGFLTATTSIFLGLFRGNLFGLEAASIFAIFTSQVWNMTFSFYASLRTVPKELQEAAAMLRLSPWQRFWKLEVPFALPHLVWNAMMSVSGGWFFVVASEAINVVGRDQTQYLPGVGSYIALAIQQANTHAMLYAGVTLFLLVLLYDQLFFRPIVAWAEKFKFEQSESSDTAQSWVLTLLKRARLSQRIARLPQPLWEWLWLKSARRNRPGEALEPPPQQRGRARLADLAFNLGVALGSLGLLGVLLGYLFGPGLGFQGGRTLQPNPNLNLELSPEIAQRFAAVGIRPGADETVWLSQVCSATQGGKQLSSRLKALLREPGVRAPADLADSCRRPLAPAGKVSWPEVPEVLKYGLFTALRVSFFVLLVTLVWLPVGVYIGLRPRLTQWAQPLAQFGAAFPANLLFPLFVVTIAHFRLNPEIWVSPLMVLGGQWYILFNVIAGTVAIPNDLKEAARMYRLRGWGLWRRLLLPAIFPAFVTGGITATGGSWNASIVAEVVRWGNTTLVATGLGAYIARWSTGEFNPHVGLGMLVMGLLVLAYNRLIWRRLYQLAEERYRLD
>NC_014213.1|WP_013159777.1|310401_311715_-|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein
MVQATRDTLLQATHLTKRFTTPEGKPFTVLDGINLELKEGEIVALLGRSGSGKSTLLRCLSGLLLPSEGEVRYRGQAVRGPMPGMAMVFQSFALFPWLTVQQNVELGLEAMGIPAPERRRRALEAIDLIGLDGFEKAFPKELSGGMRQRVGFARALVTEPEVLFMDEPFSALDVLTAETLRSELLELWGSGRIPIQSILLVTHNIEEAVLLADRILVLAANPGRIRAEVAVRLPHPREREDFAFQELVEEVYRILTTRPTPERATPEPLTLGHRLPKAPVGALTGLLERVAEGPDYGKEDLPRLAEEMRLEVDDLFPLLDAAELLGLAVLQEGDVRLTPEGQRFAQADLEERKKIFAERLLLHVPLVGHIHRVLQTRPTGRAPEERFLRELEDYMSTEDAEAVLATAIDWGRYAELFEYDYNAGVLYKNEEVPSPTP
>NC_014213.1|WP_013159785.1|320098_320380_-|CRISPR-associated-endonuclease-Cas2
MELYAIVAYDTPSDSRRAKLARLLKGFGERRQFSVFECRLRREHWALLKARIENLVDKDEDVLAVYFLPPEAVGRTYRIGHEAVKRLDEPEFI
>NC_014213.1|WP_013159786.1|320389_321370_-|CRISPR-associated-endonuclease-Cas1
MGVVYVLEDGYLAKDGGTLKVSKRGPGGGETLLEKPLIGVEEIVVLGNAVVTPALLKHCAEENIGLHYVSTGGRYFAGLTRTPAKNAPARVAQFAAHLDPTRKLALARRFVLGKLRNSLTLLRRNGAEGWEEIRWAIGELDKAADEGALRGLEGNAADVYFRSYAALLPEGFRFSERSRRPPRDPANSLLSLAYTFLAKECESALQVAGLDPYVGYLHEVRYGRASLALDLMEEFRSILADSVVLSLLNNRRLTLEDFDDAEGYPKLRKESFPKFLRAWEERLTDRVRHPLLGKAYSYRQTVLVQARVLVKHLMGELPAYEPFTVR
>NC_014213.1|WP_013159787.1|321369_321942_-|CRISPR-associated-protein-Cas4
MDEAHYLPVSKVNTAVFCPRRFYLEYVLGEVHRNHHVIEGHHLHTRAYTERGERSGVWVWSDRLGLVGVVDRIEYAGGEPVLVEYKKGRAFPQANDSDAVQLAAQALCLEESRGERARRGAVYYHASRTRREVALTPELLGRAEAAVAHMRQLLRSPRPPGVAVPPSKCAGCSTREACQPELLRREGGGG
>NC_014213.1|WP_013159788.1|322120_323089_+|WYL-domain-containing-protein
MTNENDIRLIQRLEGGAALSAVELAEHLGISRASVYRVIQRCENRGYNIVRERGRFRLASRDRDAGRFEFSLSAQQAHDLVAAVESVRRLTPYAAEALEVLRKTLIGSKLERPSAVYYHSYDEIDPEVYPRVVAAIEQRKVLELTYKPTNVKRSLSQHTFEPYRIIFWNGHYYLAGRSRTFSHKPGGGLMHLRLDRILEAKVAVAWHEGQKVPDTLTFPEPDFDPQAYVERSFGTFGGDGEPEEVVLHFPAHNAKAAAEVQRHPSRKLLPQDDGSLIYKLTVPITEELVWWAASWKGLRVLAPDHLREKVRRHCLELAYLNQ
>NC_014213.1|WP_013159789.1|323324_325877_+|CRISPR-associated-helicase/endonuclease-Cas3
MDFRTFQTNTANALMRGRSVLLHAPTGIGKSVGSALGFTEALPAGPAAPARDALLGTRLLHVLPMRALANSVAKDIAGLLERQGFGEAYRPAIHHGQQQESEIFAERVGVTTIDQYLAGFAGAPLSFSSRSGHAVAGAIVASYSVFDEVHLLGPERGLPLLYAVLQQRKRWGLLSTVMTATLPKSVRTFLAEQVGLEAVELSPADVQARDGWRRVTLSLEEVERPAERVLEEFKAHGRVIAFVNTVDAAVELYRQLQARLGPEELFLAHSNFAPSHRKAVEERLLEVFGRGSTARAVCVLTQVGEAGINISAPVVLSELAPVDSLIQRAGRCARFDTQPEGRFVVYRPRRERSHIPYGEDLVKRTEAALHNRGDSFRLDWTAENELVDEVLDAYYAHFIRGENVSRRDAEIKKARKGERVELPQPAPKTKSITIADALGLLDQTFHGRSADVLEGTLREINNVQVVVVSEPPRNAAGAEIVGAEGGASLSEFERYLAQQNLLKPYQRDTLESIPVSYGRFARRLEEQDLWELKLVKEERYDKPLYVLQRAERVRPNRTYLLTQADAGYSPTVGLSFGEVDYVEPVHGLITPVVPRLSEQAQPPKHNFQSWREHCSRVYRAVDSMLKSKYSAWIFHIAEQMQARGALESAEQFAQTLESMVRLAALLHDVGKLSRGWQREIGWREGTGEGFWAKSKEGVRVGELPPHAFHALPALRYLFCQLGVVDEQGKVDRLAELIALAASRHHSLGDPDGMLRWPPFELHEGVIEEIRQLLQDELGEDAKPVEDLITPELFDHINDAHTYERKEGQHTYLLDTPSPSEDYYPFYVLANRMIKVGDWEASGGEEVELCR
>NC_014213.1|WP_013159790.1|325867_327259_+|hypothetical-protein
MPLKFGRLGVATKTYYVQKTGFPFYDACQLVGAMHLFFGSGASSLRDLCTHWELSGPVAGANLANYGERLKGKGLERIEQTTLAVLDELEASRGAVEGFFEARPPKTEVLKKAKQEGVSRYLEPAWLTGARSPDAAQYGVLASQRGLPSKRPVPEILVATLGLTQAALAYGNDEVTTVLPVLENSVQPMTPFTTFKQRYQHRAGGAISTVFAALGILADLGLRYRIQDFAFAYHGGRGFYYSGFLGLHRLCAAFAGVKEFAHEALGYLERTRSLEAGVPLDLARLLADFLKNPSMDTLAAMARAKARVLVDEDLPVYVRAAASELLGTMVSIQEAMQMADSRQIPPPSEALVKAVGEVFRGEHEGAWIGAYINLERADKPDKFYAEVAKILSRALARAEKERKWLAKNLKEAMDSLTSEEVLSAHDQRTFPAHKTAFLLRVLASMQYQPAKLKADEPVQGEEA
>NC_014213.1|WP_013159791.1|327255_328263_+|DevR-family-CRISPR-associated-autoregulator
MNYTSLSISFRIGLAFHAMNNEGSSGTNVMEPRRISVGGHNYDGISGEMVRRHVFENLVPIAKARGLPLSPDGEGLLPDRAKRVIKAYLSGPASEVKGKDGVFELEPAHLPLVTKAALESCTITDIGGYLAAFESSEKVKGATPKRDSVFDVGWLISEEPAVVEFSQHAAYRPDGQHNLFTQNMRAAVYGGVARLDLGRIGYNDWAWLAPDRNDLHLSDEQRRQRAAALLDAWEQWLLSPAGAKQAGWLQHTGQLEGVLMLSNFGPAPFRSPIEVELRYDAEGNPLVERIKPNPRYRAELATLAEAKPGRYRALEFDDLAGLAKAFDQARAAIGL
>NC_014213.1|WP_013159792.1|328271_329021_+|hypothetical-protein
MSEIWLRARFLTHSFHYRMPDTVAISAVNPAVPSPLTVQMAMLAAYLREGERGKAQALLELLPLKVRVRPPRGAVIYRGIMRYVRPPKDAGDLDKNTGAGYKISPHFREFALLDGPLEVYVLVPAEHRGLVAEALERIPYLGAKDSLVSCQGEVEPVDEPPSDCAVALEDVDLSELADYVVLQLADFEGRERLFPPAKGKQKAQDKVLTLERLLPSQRLKEHYRLGAYLVEGQVYSSGNVKVFRRGGGG
>NC_014213.1|WP_013159793.1|329020_329827_+|CRISPR-associated-endoribonuclease-Cas6
MPYAFLLHLTSSDPRPPRYPGLYAHGLFFALLGKLDPGLAAAVHAAPRKPFTLAVLEPTPRARRGGEASGEVVLRVTTLDDDLFAPLLGVLLREGVAGLALGDHPYRLARVVATPQGSPLAGRHTWEELATAPPTRGLRLRFRTPTVFATSKPGRRTRHTPLPDPFLIAKSLLTSWQYHSPLRLSDTEAAALLTLFELDLELIRFADLRFERAQAAKGFFPGFTGAVEVHCHSDSLEVQRTLGILQAYAFYAGVGAKTAYGLGLTVPY
>NC_014213.1|WP_148225922.1|330969_332093_-|IS3-like-element-ISMesi1-family-transposase
MRRWSAKEKVKIVLEVLSGQRTVAEACRAHEVAESVLYRWQRAFLDNAHAAFSHSCAEQEARVRELERLVGQMALELEVPKKSLGTLPAKERRELVMALKEAYPLRLLCRALGVPRSTLYYRSKGPNPEEAVLRGRLRELAGAWPRYGYRRLAALLRGEGFGVGEKRVRSLMRREGLLLTRKPLKPRTTLPEELLPEGVPNLLLGLEVTGFHQVWVADLSYVVLGEGVAYLAVVMDLHTRKILGVALGPRLSQGLALAALEMALREGCPEVHHSDRGVQYTSRAYVERLLGLGVRLSYAGTGRPWENGHAERLIRTVKEEWVDLREYRTLEEARASVEAFVFEVYNRKRPHSALGYLTPEAFVDSLLKGGGSPD

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Crispr_ID: NC_014213_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014213_4

333510-333898

Unclear

Consensus_repeat	Method
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	PILER-CR
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	CRISPRCasFinder
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	CRT

5 spacers

cas6,cas5,cas7,cas8a8,cas3,WYL,cas4,cas1

The CRISPR arrays of NC_014213_4

>merge|NC_014213|4|333510-333898|PILER-CR,CRISPRCasFinder,CRT
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAACGTTGCGGTGAACATCGTGCCCGACTGGTGGAGGGTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAACAGCAAACGCTCGGTGGCCTGGGTGGCCTCCGGCCGTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAACATTGCAGGAGATGGTGGGGCGATAGGGTGGAGCCTGTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAACCCCCCATACTGGTGGATGGCCGCGTAGCGCACGTTGGTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAACGACTCCTGATCAGAGGACTAGGGAGCAATGTCCGCGTTGCAAAAGCGACTAAGGGGATTGAAACCAACAGC

>NC_014213|4|4|333510-333827|PILER-CR
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	GTTGCGGTGAACATCGTGCCCGACTGGTGGAGG
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	AGCAAACGCTCGGTGGCCTGGGTGGCCTCCGGCC
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	ATTGCAGGAGATGGTGGGGCGATAGGGTGGAGCCT
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	CCCCCATACTGGTGGATGGCCGCGTAGCGCACGTTG
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC

>NC_014213|4|4|333510-333827|CRISPRCasFinder
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	GTTGCGGTGAACATCGTGCCCGACTGGTGGAGG
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	AGCAAACGCTCGGTGGCCTGGGTGGCCTCCGGCC
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	ATTGCAGGAGATGGTGGGGCGATAGGGTGGAGCCT
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	CCCCCATACTGGTGGATGGCCGCGTAGCGCACGTTG
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC

>NC_014213|4|4|333510-333898|CRT
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	GTTGCGGTGAACATCGTGCCCGACTGGTGGAGG
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	AGCAAACGCTCGGTGGCCTGGGTGGCCTCCGGCC
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	ATTGCAGGAGATGGTGGGGCGATAGGGTGGAGCCT
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	CCCCCATACTGGTGGATGGCCGCGTAGCGCACGTTG
GTTGCAAAAGCGACTAACCTCGTAGAGGATTGAAAC	GACTCCTGATCAGAGGACTAGGGAGCAATGTCCGC
GTTGCAAAAGCGACTAAGGGGATTGAAACCAACAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014213.1\|WP_083771743.1\|342769_343057_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|215567
NC_014213.1\|WP_013159790.1\|325867_327259_+\|hypothetical-protein	cas8a8	mkCas0180_cas8a8_CAS-I-A	unknown
NC_014213.1\|WP_083771749.1\|334728_334767_+\|excalibur-calcium-binding-domain-containing-protein	unknown	unknown	unknown
NC_014213.1\|WP_013159792.1\|328271_329021_+\|hypothetical-protein	cas5	cls000048_cas5_CAS-I-A	unknown
NC_014213.1\|WP_013159796.1\|333991_334366_+\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_083771742.1\|338417_340493_-\|chorismate-binding-protein	unknown	unknown	gnl\|CDD\|223225
NC_014213.1\|WP_013159798.1\|336252_337020_-\|hypothetical-protein	unknown	unknown	unknown
NC_014213.1\|WP_013159786.1\|320389_321370_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|376633
NC_014213.1\|WP_013159795.1\|332339_333428_+\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_014213.1\|WP_013159791.1\|327255_328263_+\|DevR-family-CRISPR-associated-autoregulator	cas7	pfam01905_cas7_CAS-I	gnl\|CDD\|376656
NC_014213.1\|WP_013159788.1\|322120_323089_+\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_014213.1\|WP_013159797.1\|335296_335671_-\|DUF433-domain-containing-protein	unknown	unknown	gnl\|CDD\|377269
NC_014213.1\|WP_041653874.1\|343463_344264_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_014213.1\|WP_013159799.1\|337576_338401_-\|aminotransferase-class-IV	unknown	unknown	gnl\|CDD\|376449
NC_014213.1\|WP_013159801.1\|340618_341563_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271175
NC_014213.1\|WP_013159789.1\|323324_325877_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_014213.1\|WP_013159787.1\|321369_321942_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NC_014213.1\|WP_148225922.1\|330969_332093_-\|IS3-like-element-ISMesi1-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_014213.1\|WP_013159793.1\|329020_329827_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_014213.1\|WP_013159802.1\|342448_342706_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274729

Protein	Function_ID	Function_description	E-value
NC_014213.1\|WP_083771743.1\|342769_343057_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|215567	PLN03087, PLN03087, BODYGUARD 1 domain containing hydrolase; Provisional.	8.84573e-06
NC_014213.1\|WP_083771742.1\|338417_340493_-\|chorismate-binding-protein	gnl\|CDD\|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	2.80098e-136
NC_014213.1\|WP_013159791.1\|327255_328263_+\|DevR-family-CRISPR-associated-autoregulator	gnl\|CDD\|376656	pfam01905, DevR, CRISPR-associated negative auto-regulator DevR/Csa2. This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats. It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation. Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers. This family used to be known as DUF73. DevR appears to be negative auto-regulator within the system.	2.50464e-36
NC_014213.1\|WP_013159786.1\|320389_321370_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	5.56017e-110
NC_014213.1\|WP_013159795.1\|332339_333428_+\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	8.09412e-18
NC_014213.1\|WP_013159793.1\|329020_329827_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	4.03885e-18
NC_014213.1\|WP_013159788.1\|322120_323089_+\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	5.134e-30
NC_014213.1\|WP_041653874.1\|343463_344264_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.57512e-32
NC_014213.1\|WP_013159799.1\|337576_338401_-\|aminotransferase-class-IV	gnl\|CDD\|376449	pfam01063, Aminotran_4, Amino-transferase class IV. The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.	4.15704e-36
NC_014213.1\|WP_013159801.1\|340618_341563_-\|site-specific-integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	2.18523e-12
NC_014213.1\|WP_013159789.1\|323324_325877_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	3.07775e-51
NC_014213.1\|WP_013159787.1\|321369_321942_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	6.62157e-33
NC_014213.1\|WP_148225922.1\|330969_332093_-\|IS3-like-element-ISMesi1-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.07047e-45
NC_014213.1\|WP_013159797.1\|335296_335671_-\|DUF433-domain-containing-protein	gnl\|CDD\|377269	pfam04255, DUF433, Protein of unknown function (DUF433).	2.27923e-11
NC_014213.1\|WP_013159802.1\|342448_342706_+\|hypothetical-protein	gnl\|CDD\|274729	TIGR03695, menH_SHCHC, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0.00151539

>NC_014213.1|WP_013159795.1|332339_333428_+|transposase
MQFTTVGREIWRGARQAQRLAEANASDPEVQERLRKLRLVKALRESKKSWKEIQDLVGISRATYHRWQKALKEKGLAGLKPRSRRPKHLRTKVHWTPGLLIRIETLRKENPTWGRWSIWLTLRKEGFQMSERTVGRILAYLEKHRRIESVAGYLARTQRGKLKRRVNRPYAKRKPRGYEARAPGDLVQVDTLTLTLGPGSMVKHFSAIDLHSRFVLAEVHSRATAKLSEGFLSLLLARAPFPIRAIQVDGGSEFMAEFEEACCALGIALFVLPPRSPKLNGHVERMQRTFKEEFYTRPLPTPLSELQAELDTYLDYYNRRRPHMALGGLAPLEFLAKMQEESVPQRVSNVLTDYICYLEGFS
>NC_014213.1|WP_148225922.1|330969_332093_-|IS3-like-element-ISMesi1-family-transposase
MRRWSAKEKVKIVLEVLSGQRTVAEACRAHEVAESVLYRWQRAFLDNAHAAFSHSCAEQEARVRELERLVGQMALELEVPKKSLGTLPAKERRELVMALKEAYPLRLLCRALGVPRSTLYYRSKGPNPEEAVLRGRLRELAGAWPRYGYRRLAALLRGEGFGVGEKRVRSLMRREGLLLTRKPLKPRTTLPEELLPEGVPNLLLGLEVTGFHQVWVADLSYVVLGEGVAYLAVVMDLHTRKILGVALGPRLSQGLALAALEMALREGCPEVHHSDRGVQYTSRAYVERLLGLGVRLSYAGTGRPWENGHAERLIRTVKEEWVDLREYRTLEEARASVEAFVFEVYNRKRPHSALGYLTPEAFVDSLLKGGGSPD
>NC_014213.1|WP_013159793.1|329020_329827_+|CRISPR-associated-endoribonuclease-Cas6
MPYAFLLHLTSSDPRPPRYPGLYAHGLFFALLGKLDPGLAAAVHAAPRKPFTLAVLEPTPRARRGGEASGEVVLRVTTLDDDLFAPLLGVLLREGVAGLALGDHPYRLARVVATPQGSPLAGRHTWEELATAPPTRGLRLRFRTPTVFATSKPGRRTRHTPLPDPFLIAKSLLTSWQYHSPLRLSDTEAAALLTLFELDLELIRFADLRFERAQAAKGFFPGFTGAVEVHCHSDSLEVQRTLGILQAYAFYAGVGAKTAYGLGLTVPY
>NC_014213.1|WP_013159792.1|328271_329021_+|hypothetical-protein
MSEIWLRARFLTHSFHYRMPDTVAISAVNPAVPSPLTVQMAMLAAYLREGERGKAQALLELLPLKVRVRPPRGAVIYRGIMRYVRPPKDAGDLDKNTGAGYKISPHFREFALLDGPLEVYVLVPAEHRGLVAEALERIPYLGAKDSLVSCQGEVEPVDEPPSDCAVALEDVDLSELADYVVLQLADFEGRERLFPPAKGKQKAQDKVLTLERLLPSQRLKEHYRLGAYLVEGQVYSSGNVKVFRRGGGG
>NC_014213.1|WP_013159791.1|327255_328263_+|DevR-family-CRISPR-associated-autoregulator
MNYTSLSISFRIGLAFHAMNNEGSSGTNVMEPRRISVGGHNYDGISGEMVRRHVFENLVPIAKARGLPLSPDGEGLLPDRAKRVIKAYLSGPASEVKGKDGVFELEPAHLPLVTKAALESCTITDIGGYLAAFESSEKVKGATPKRDSVFDVGWLISEEPAVVEFSQHAAYRPDGQHNLFTQNMRAAVYGGVARLDLGRIGYNDWAWLAPDRNDLHLSDEQRRQRAAALLDAWEQWLLSPAGAKQAGWLQHTGQLEGVLMLSNFGPAPFRSPIEVELRYDAEGNPLVERIKPNPRYRAELATLAEAKPGRYRALEFDDLAGLAKAFDQARAAIGL
>NC_014213.1|WP_013159790.1|325867_327259_+|hypothetical-protein
MPLKFGRLGVATKTYYVQKTGFPFYDACQLVGAMHLFFGSGASSLRDLCTHWELSGPVAGANLANYGERLKGKGLERIEQTTLAVLDELEASRGAVEGFFEARPPKTEVLKKAKQEGVSRYLEPAWLTGARSPDAAQYGVLASQRGLPSKRPVPEILVATLGLTQAALAYGNDEVTTVLPVLENSVQPMTPFTTFKQRYQHRAGGAISTVFAALGILADLGLRYRIQDFAFAYHGGRGFYYSGFLGLHRLCAAFAGVKEFAHEALGYLERTRSLEAGVPLDLARLLADFLKNPSMDTLAAMARAKARVLVDEDLPVYVRAAASELLGTMVSIQEAMQMADSRQIPPPSEALVKAVGEVFRGEHEGAWIGAYINLERADKPDKFYAEVAKILSRALARAEKERKWLAKNLKEAMDSLTSEEVLSAHDQRTFPAHKTAFLLRVLASMQYQPAKLKADEPVQGEEA
>NC_014213.1|WP_013159789.1|323324_325877_+|CRISPR-associated-helicase/endonuclease-Cas3
MDFRTFQTNTANALMRGRSVLLHAPTGIGKSVGSALGFTEALPAGPAAPARDALLGTRLLHVLPMRALANSVAKDIAGLLERQGFGEAYRPAIHHGQQQESEIFAERVGVTTIDQYLAGFAGAPLSFSSRSGHAVAGAIVASYSVFDEVHLLGPERGLPLLYAVLQQRKRWGLLSTVMTATLPKSVRTFLAEQVGLEAVELSPADVQARDGWRRVTLSLEEVERPAERVLEEFKAHGRVIAFVNTVDAAVELYRQLQARLGPEELFLAHSNFAPSHRKAVEERLLEVFGRGSTARAVCVLTQVGEAGINISAPVVLSELAPVDSLIQRAGRCARFDTQPEGRFVVYRPRRERSHIPYGEDLVKRTEAALHNRGDSFRLDWTAENELVDEVLDAYYAHFIRGENVSRRDAEIKKARKGERVELPQPAPKTKSITIADALGLLDQTFHGRSADVLEGTLREINNVQVVVVSEPPRNAAGAEIVGAEGGASLSEFERYLAQQNLLKPYQRDTLESIPVSYGRFARRLEEQDLWELKLVKEERYDKPLYVLQRAERVRPNRTYLLTQADAGYSPTVGLSFGEVDYVEPVHGLITPVVPRLSEQAQPPKHNFQSWREHCSRVYRAVDSMLKSKYSAWIFHIAEQMQARGALESAEQFAQTLESMVRLAALLHDVGKLSRGWQREIGWREGTGEGFWAKSKEGVRVGELPPHAFHALPALRYLFCQLGVVDEQGKVDRLAELIALAASRHHSLGDPDGMLRWPPFELHEGVIEEIRQLLQDELGEDAKPVEDLITPELFDHINDAHTYERKEGQHTYLLDTPSPSEDYYPFYVLANRMIKVGDWEASGGEEVELCR
>NC_014213.1|WP_013159788.1|322120_323089_+|WYL-domain-containing-protein
MTNENDIRLIQRLEGGAALSAVELAEHLGISRASVYRVIQRCENRGYNIVRERGRFRLASRDRDAGRFEFSLSAQQAHDLVAAVESVRRLTPYAAEALEVLRKTLIGSKLERPSAVYYHSYDEIDPEVYPRVVAAIEQRKVLELTYKPTNVKRSLSQHTFEPYRIIFWNGHYYLAGRSRTFSHKPGGGLMHLRLDRILEAKVAVAWHEGQKVPDTLTFPEPDFDPQAYVERSFGTFGGDGEPEEVVLHFPAHNAKAAAEVQRHPSRKLLPQDDGSLIYKLTVPITEELVWWAASWKGLRVLAPDHLREKVRRHCLELAYLNQ
>NC_014213.1|WP_013159787.1|321369_321942_-|CRISPR-associated-protein-Cas4
MDEAHYLPVSKVNTAVFCPRRFYLEYVLGEVHRNHHVIEGHHLHTRAYTERGERSGVWVWSDRLGLVGVVDRIEYAGGEPVLVEYKKGRAFPQANDSDAVQLAAQALCLEESRGERARRGAVYYHASRTRREVALTPELLGRAEAAVAHMRQLLRSPRPPGVAVPPSKCAGCSTREACQPELLRREGGGG
>NC_014213.1|WP_013159786.1|320389_321370_-|CRISPR-associated-endonuclease-Cas1
MGVVYVLEDGYLAKDGGTLKVSKRGPGGGETLLEKPLIGVEEIVVLGNAVVTPALLKHCAEENIGLHYVSTGGRYFAGLTRTPAKNAPARVAQFAAHLDPTRKLALARRFVLGKLRNSLTLLRRNGAEGWEEIRWAIGELDKAADEGALRGLEGNAADVYFRSYAALLPEGFRFSERSRRPPRDPANSLLSLAYTFLAKECESALQVAGLDPYVGYLHEVRYGRASLALDLMEEFRSILADSVVLSLLNNRRLTLEDFDDAEGYPKLRKESFPKFLRAWEERLTDRVRHPLLGKAYSYRQTVLVQARVLVKHLMGELPAYEPFTVR
>NC_014213.1|WP_013159796.1|333991_334366_+|hypothetical-protein
MDDRKLNPLRLAFLVSIALYFAFVGLRLPTKNPSETIPQATQAPLVQPQVRIDGCHAHISEATASTRELRLKVSGTAETLRVSYDGGMIVKATEEVCSGGECRVFTPAAPKTIQLDGCPAITLP
>NC_014213.1|WP_083771749.1|334728_334767_+|excalibur-calcium-binding-domain-containing-protein
MDRDGDGVACER
>NC_014213.1|WP_013159797.1|335296_335671_-|DUF433-domain-containing-protein
MQKWRASPGTKGVTDPSALLQGITLEPEINHGQPTVRGLRYPVRVILELLAGGMTPGVVVTKDADCVQSLILQGKPYKLPLISTGNISNQALENLFLEQQKVLCELLNTYRYVELGREEMVAHL
>NC_014213.1|WP_013159798.1|336252_337020_-|hypothetical-protein
MTPPQRLLERLEAIGRSLQASGHALALIGLGSVGLERDRLDEHSDLDFFALVEPGQKARYLQDLSWLSDVAPVVFLFPNTADGYKLLYADGIFCEFAVFEPQELEQIPFAAGQVVWSRAGVDASVATPTRRAMGGARPGMEWHLGEALTNLYVGLKRYRRGEKLSAMRFVQGFALDRVLELASVLETEQPARRDPFNNERRLEQRFPRISARLSEFAQGYERTPEAALAQLAFLEQHFEVNAAMAREIRALAALR
>NC_014213.1|WP_013159799.1|337576_338401_-|aminotransferase-class-IV
MTRINGEPVGTPLPESLWHGFFVFTTLRLEGGEPLWLPEHLERLRRHARALGIAFPGFEALEREVEHYCRPRADLLLRLAVAPEGYASSARPFAPPPEPAYARGVSIHVTSLRVHPDLGRYKTGNYLPYRLARRAAERAGHFEGLLLDLEGHVVDGSRTSPLLYRAGELGVLPGGVEGVTRQKVLEYAVQMGLRVTEARLKPVALPACFARRANTSCGQTRFDELQGQLLLAGTGVGLVPVGPPQDSLLEALIARFRPLPRDGITPAPSGQGPP
>NC_014213.1|WP_083771742.1|338417_340493_-|chorismate-binding-protein
MRHIGTASPHRLSRERSAVKSAHAQEDAASLYARARAFGLRPALLESAGAVTRCGRLTLLGVGATRRLEVWDGVTYLDGAAVGDALAVFRFLEQGLGEGYFPAWIGFFAYEYARHLGLPSHAPLPGLPEAAFYYYPEGYAWLEGRRVQSPSSELAPLLAEPGPLPKVDLHRDYPRDAFLAGVAEVQERIRAGWVYQVNLSQRFHFAADGIDPLALYQALRRYNPSPFMGLLEGEANSLAGPAPPVRREGYAVVSGSPERLFDYRGGTITARPIAGTRPRGRTPEHDEALGAELRANAKERAEHVMLVDLLRNDLARVCAPGSVEVSEAFTLERYSHVMHLVSEVRGRGRAPLREAFASIFPGGTITGAPKESVMRTIAELEPVPRGAYTGSMGYVSGKGCDFNILIRSFSFAGGTGYFSAGAGVVIESEPEREYAETQAKAEALLQALGQGRAGQPPAPPRSDSAWKPPRPPRRWRARVLFLENHDSFSYNIVDYLAALGAEIRVLDHGQAPDLSWATHLVVGPGPGEPATAGRTLEWTRAALEARLPFLGICLGHQALGVALGARLERSPRPVHGEAFPVEHRGEGIFAGVPSPARFTRYHSLLLPSLRSAKPHLRDLPPTLRLEAWTRGEGEAPGARLCMAVSHARGPAWGVQFHPESMLSEYGMVLLSNFLSLSPVDGPAGRPEPTLS
>NC_014213.1|WP_013159801.1|340618_341563_-|site-specific-integrase
MLLPASPLDDPQARQEWVARALATWDRQALGEAALYASRLFGWHERQTLAVLHNLCYWCREQGYTWPHLPQNALLLFWEEATTHRPPLSPRPLRKDTTLYAWWRGLRRTLEVLAWAGAEMPRLELPPKPQYALVRPYLSEPEFAALLGAARSHPEGRLRRLGVAVLYLLGEAGVWPKELFALRLEDFHPASRVLRVRGEKARTVPLSKEATEALQEYLEDRESIATLAPLPSPYLFVRMTNKKGGLGRPLNMNSLRPLLERACELSGVFPERILGALRWRAVRRYLQQGLPPAEVVRRTGVASVAPLGRERGQR
>NC_014213.1|WP_013159802.1|342448_342706_+|hypothetical-protein
MRYVLASSFFFALLPQAFGQSIQPIKIQVNGVELYCIEKGQGETLILLHGGMGDYRSWNPQIQTFAPDYRVISYADAIITRIKIL
>NC_014213.1|WP_083771743.1|342769_343057_+|alpha/beta-fold-hydrolase
MKRAHLVGQSYGALTALVFAIKHPGMVRTLVLGEPPAHQLIRNSSDGEAVYQDFMSNTWKPAAEAFRKGEDKQALDVLALGIAGKGFDEFGCCER
>NC_014213.1|WP_041653874.1|343463_344264_+|alpha/beta-hydrolase
MKEVLLGDLRIAYAEAGYGPPLVLLHGGMDDSRSWRRQMDALSDEFTVLAWDAPGCGRSSDVSQSWRMPNYADALAGWLVALGVERPHILGLSWGSSVALEFYRRHSHVPASLILAGAYAGWAGSLPPEEVASRLESVLAAADLPREQLLTGLPGVLSSAAPAELVDELSAIWADNAGRSHPEGYRAMAESDLRDVLPGIHLRTLLVYGELDQRAPLQVANDLHQRIPRAKLVVIPGVGHLANVEAPDEFNAQVRLFIRSVVSDDC

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014213_1	1.1\|125477\|34\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	125477-125510	34	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	125477-125510	0	1.0
NC_014213_1	1.2\|125548\|34\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	125548-125581	34	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	125548-125581	0	1.0
NC_014213_1	1.3\|125619\|36\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	125619-125654	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	125619-125654	0	1.0
NC_014213_1	1.4\|125692\|34\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	125692-125725	34	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	125692-125725	0	1.0
NC_014213_2	2.1\|127232\|34\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	127232-127265	34	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	127232-127265	0	1.0
NC_014213_2	2.2\|127303\|35\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	127303-127337	35	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	127303-127337	0	1.0
NC_014213_2	2.3\|127375\|35\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	127375-127409	35	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	127375-127409	0	1.0
NC_014213_2	2.4\|127447\|35\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	127447-127481	35	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	127447-127481	0	1.0
NC_014213_3	3.1\|318343\|36\|NC_014213\|CRT	318343-318378	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318343-318378	0	1.0
NC_014213_3	3.2\|318415\|35\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318415-318449	35	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318415-318449	0	1.0
NC_014213_3	3.3\|318486\|36\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318486-318521	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318486-318521	0	1.0
NC_014213_3	3.4\|318558\|36\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318558-318593	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318558-318593	0	1.0
NC_014213_3	3.5\|318630\|39\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318630-318668	39	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318630-318668	0	1.0
NC_014213_3	3.6\|318705\|36\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318705-318740	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318705-318740	0	1.0
NC_014213_3	3.7\|318777\|37\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318777-318813	37	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318777-318813	0	1.0
NC_014213_3	3.7\|318777\|37\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318777-318813	37	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318918-318954	0	1.0
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318850-318881	0	1.0
NC_014213_3	3.9\|318918\|37\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318918-318954	37	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318777-318813	0	1.0
NC_014213_3	3.9\|318918\|37\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318918-318954	37	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318918-318954	0	1.0
NC_014213_3	3.10\|318991\|35\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318991-319025	35	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	318991-319025	0	1.0
NC_014213_3	3.11\|319062\|37\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319062-319098	37	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319062-319098	0	1.0
NC_014213_3	3.12\|319135\|36\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319135-319170	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319135-319170	0	1.0
NC_014213_3	3.13\|319207\|36\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319207-319242	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319207-319242	0	1.0
NC_014213_3	3.14\|319279\|34\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319279-319312	34	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319279-319312	0	1.0
NC_014213_3	3.15\|319349\|36\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319349-319384	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319349-319384	0	1.0
NC_014213_3	3.16\|319421\|36\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319421-319456	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319421-319456	0	1.0
NC_014213_3	3.17\|319493\|34\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319493-319526	34	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319493-319526	0	1.0
NC_014213_3	3.18\|319563\|36\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319563-319598	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319563-319598	0	1.0
NC_014213_3	3.19\|319635\|37\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319635-319671	37	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319635-319671	0	1.0
NC_014213_3	3.20\|319708\|37\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319708-319744	37	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319708-319744	0	1.0
NC_014213_3	3.21\|319781\|39\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319781-319819	39	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	319781-319819	0	1.0
NC_014213_4	4.1\|333546\|33\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	333546-333578	33	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	333546-333578	0	1.0
NC_014213_4	4.2\|333615\|34\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	333615-333648	34	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	333615-333648	0	1.0
NC_014213_4	4.3\|333685\|35\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	333685-333719	35	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	333685-333719	0	1.0
NC_014213_4	4.4\|333756\|36\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	333756-333791	36	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	333756-333791	0	1.0
NC_014213_4	4.5\|333828\|35\|NC_014213\|CRT	333828-333862	35	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	333828-333862	0	1.0
NC_014213_4	4.4\|333756\|36\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	333756-333791	36	MK071653	Meiothermus phage MMP7, complete genome	26280-26315	1	0.972
NC_014213_4	4.4\|333756\|36\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	333756-333791	36	MH939157	UNVERIFIED: Meiothermus phage MMP17, complete genome	17921-17956	1	0.972
NC_014213_3	3.10\|318991\|35\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318991-319025	35	MK071653	Meiothermus phage MMP7, complete genome	19352-19386	5	0.857
NC_014213_3	3.10\|318991\|35\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318991-319025	35	MH939157	UNVERIFIED: Meiothermus phage MMP17, complete genome	10993-11027	5	0.857
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	158818-158849	6	0.812
NC_014213_4	4.2\|333615\|34\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	333615-333648	34	JX469828	Uncultured bacterium plasmid pRSB223, complete sequence	296-329	6	0.824
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_LR134454	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence	66977-67008	7	0.781
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1262931-1262962	7	0.781
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	186570-186601	7	0.781
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP016560	Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence	521917-521948	7	0.781
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP007795	Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence	398717-398748	7	0.781
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP032347	Azospirillum brasilense strain MTCC4039 plasmid p2, complete sequence	354131-354162	7	0.781
NC_014213_4	4.2\|333615\|34\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	333615-333648	34	NZ_CP016617	Microvirga ossetica strain V5/3m plasmid unnamed1, complete sequence	1015105-1015138	7	0.794
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3054052-3054083	8	0.75
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP032323	Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence	707434-707465	8	0.75
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP032341	Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence	701849-701880	8	0.75
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP033321	Azospirillum brasilense strain Cd plasmid p3, complete sequence	699363-699394	8	0.75
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP033315	Azospirillum brasilense strain Sp 7 plasmid p3, complete sequence	697524-697555	8	0.75
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP012916	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence	346755-346786	8	0.75
NC_014213_4	4.2\|333615\|34\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	333615-333648	34	MH271305	Gordonia phage Morrissey, complete genome	12123-12156	8	0.765
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_AP022602	Mycobacterium gallinarum strain JCM 6399 plasmid pJCM6399	107559-107590	9	0.719
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP034710	Salmonella enterica subsp. enterica serovar Karamoja strain RSE21 plasmid pRSE21, complete sequence	85258-85289	9	0.719
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NC_049470	Arthrobacter phage TripleJ, complete genome	16104-16135	9	0.719
NC_014213_3	3.11\|319062\|37\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	319062-319098	37	NZ_CP029831	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence	480183-480219	10	0.73
NC_014213_4	4.2\|333615\|34\|NC_014213\|PILER-CR,CRISPRCasFinder,CRT	333615-333648	34	NZ_CP026221	Aeromonas sp. ASNIH4 plasmid pAER-f909, complete sequence	133452-133485	10	0.706
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	393118-393149	11	0.656
NC_014213_3	3.8\|318850\|32\|NC_014213\|CRT,PILER-CR,CRISPRCasFinder	318850-318881	32	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	240999-241030	11	0.656

1. spacer 1.1|125477|34|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

tttctaaggcgctcctagacaagcctcaatgtct	CRISPR spacer
tttctaaggcgctcctagacaagcctcaatgtct	Protospacer
**********************************

2. spacer 1.2|125548|34|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

ctttggcctaatcacaccattggaatatttcaag	CRISPR spacer
ctttggcctaatcacaccattggaatatttcaag	Protospacer
**********************************

3. spacer 1.3|125619|36|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

cagaattgtatttaggtattcctgtgtagtcagtcc	CRISPR spacer
cagaattgtatttaggtattcctgtgtagtcagtcc	Protospacer
************************************

4. spacer 1.4|125692|34|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

ggcagtaagtattgacaagccgctcgagttatgc	CRISPR spacer
ggcagtaagtattgacaagccgctcgagttatgc	Protospacer
**********************************

5. spacer 2.1|127232|34|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

tcgagtacgcggggatcgtgaccaacatcggccc	CRISPR spacer
tcgagtacgcggggatcgtgaccaacatcggccc	Protospacer
**********************************

6. spacer 2.2|127303|35|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

attgttttatacaggccagtagggtaaacgcaaag	CRISPR spacer
attgttttatacaggccagtagggtaaacgcaaag	Protospacer
***********************************

7. spacer 2.3|127375|35|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

actagtttaaatactttctttaatgtttaaaaata	CRISPR spacer
actagtttaaatactttctttaatgtttaaaaata	Protospacer
***********************************

8. spacer 2.4|127447|35|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

tcagcggtttgcaaacaggctgcggtgtgggttca	CRISPR spacer
tcagcggtttgcaaacaggctgcggtgtgggttca	Protospacer
***********************************

9. spacer 3.1|318343|36|NC_014213|CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

ccggctcatcaaatttccgactccgctagttggcca	CRISPR spacer
ccggctcatcaaatttccgactccgctagttggcca	Protospacer
************************************

10. spacer 3.2|318415|35|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

ccggcacttcctgaggtttccgtgtgagctatttt	CRISPR spacer
ccggcacttcctgaggtttccgtgtgagctatttt	Protospacer
***********************************

11. spacer 3.3|318486|36|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

gccctacgagacgggcaagcccgcgccccagggcga	CRISPR spacer
gccctacgagacgggcaagcccgcgccccagggcga	Protospacer
************************************

12. spacer 3.4|318558|36|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

cctgaggaaaccagacggacgcagcctttcaagatt	CRISPR spacer
cctgaggaaaccagacggacgcagcctttcaagatt	Protospacer
************************************

13. spacer 3.5|318630|39|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

ggagatccccgctgccttgagagcgagggcggtgtcgag	CRISPR spacer
ggagatccccgctgccttgagagcgagggcggtgtcgag	Protospacer
***************************************

14. spacer 3.6|318705|36|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

gcgcttgaaccgggcgagcagctcctccaaggtcgt	CRISPR spacer
gcgcttgaaccgggcgagcagctcctccaaggtcgt	Protospacer
************************************

15. spacer 3.7|318777|37|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

cgtgagcggtcacccggatgcgctctccccgctcagc	CRISPR spacer
cgtgagcggtcacccggatgcgctctccccgctcagc	Protospacer
*************************************

16. spacer 3.7|318777|37|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

cgtgagcggtcacccggatgcgctctccccgctcagc	CRISPR spacer
cgtgagcggtcacccggatgcgctctccccgctcagc	Protospacer
*************************************

17. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

gggagccccgacggctcggcggccacccaccg	CRISPR spacer
gggagccccgacggctcggcggccacccaccg	Protospacer
********************************

18. spacer 3.9|318918|37|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

cgtgagcggtcacccggatgcgctctccccgctcagc	CRISPR spacer
cgtgagcggtcacccggatgcgctctccccgctcagc	Protospacer
*************************************

19. spacer 3.9|318918|37|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

cgtgagcggtcacccggatgcgctctccccgctcagc	CRISPR spacer
cgtgagcggtcacccggatgcgctctccccgctcagc	Protospacer
*************************************

20. spacer 3.10|318991|35|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

accaccaccgtgccgcccgcttcccataggtaggc	CRISPR spacer
accaccaccgtgccgcccgcttcccataggtaggc	Protospacer
***********************************

21. spacer 3.11|319062|37|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

ggggcggctccgccgccagggagggggcgatatggcg	CRISPR spacer
ggggcggctccgccgccagggagggggcgatatggcg	Protospacer
*************************************

22. spacer 3.12|319135|36|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

ttataaaaccatccctgggcgtctctggcacgcttg	CRISPR spacer
ttataaaaccatccctgggcgtctctggcacgcttg	Protospacer
************************************

23. spacer 3.13|319207|36|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

ttgcctcccaccatgggtggtctgctggaagcaccg	CRISPR spacer
ttgcctcccaccatgggtggtctgctggaagcaccg	Protospacer
************************************

24. spacer 3.14|319279|34|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

cttcaggatttcgtgaaggccctcgagggttacg	CRISPR spacer
cttcaggatttcgtgaaggccctcgagggttacg	Protospacer
**********************************

25. spacer 3.15|319349|36|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

ggcaggcagagggtgagcatgcggcctaggtatccc	CRISPR spacer
ggcaggcagagggtgagcatgcggcctaggtatccc	Protospacer
************************************

26. spacer 3.16|319421|36|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

cgttgagggcccgcaagggctggcggggatgcatct	CRISPR spacer
cgttgagggcccgcaagggctggcggggatgcatct	Protospacer
************************************

27. spacer 3.17|319493|34|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

acctgtactcgttcgactgtattgctcccagcta	CRISPR spacer
acctgtactcgttcgactgtattgctcccagcta	Protospacer
**********************************

28. spacer 3.18|319563|36|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

tgagctgtaccaggcggcacgcccaatgctggcggt	CRISPR spacer
tgagctgtaccaggcggcacgcccaatgctggcggt	Protospacer
************************************

29. spacer 3.19|319635|37|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

acctcgcccggtctccccctctcgctaggggcatttt	CRISPR spacer
acctcgcccggtctccccctctcgctaggggcatttt	Protospacer
*************************************

30. spacer 3.20|319708|37|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

gcaagtcccatcgaacggggggagaaacttcaacaag	CRISPR spacer
gcaagtcccatcgaacggggggagaaacttcaacaag	Protospacer
*************************************

31. spacer 3.21|319781|39|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

tccaatcgagccccagtcatcaccggcactcccaacaag	CRISPR spacer
tccaatcgagccccagtcatcaccggcactcccaacaag	Protospacer
***************************************

32. spacer 4.1|333546|33|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

gttgcggtgaacatcgtgcccgactggtggagg	CRISPR spacer
gttgcggtgaacatcgtgcccgactggtggagg	Protospacer
*********************************

33. spacer 4.2|333615|34|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

agcaaacgctcggtggcctgggtggcctccggcc	CRISPR spacer
agcaaacgctcggtggcctgggtggcctccggcc	Protospacer
**********************************

34. spacer 4.3|333685|35|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

attgcaggagatggtggggcgatagggtggagcct	CRISPR spacer
attgcaggagatggtggggcgatagggtggagcct	Protospacer
***********************************

35. spacer 4.4|333756|36|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

cccccatactggtggatggccgcgtagcgcacgttg	CRISPR spacer
cccccatactggtggatggccgcgtagcgcacgttg	Protospacer
************************************

36. spacer 4.5|333828|35|NC_014213|CRT matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 0, identity: 1.0

gactcctgatcagaggactagggagcaatgtccgc	CRISPR spacer
gactcctgatcagaggactagggagcaatgtccgc	Protospacer
***********************************

37. spacer 4.4|333756|36|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to MK071653 (Meiothermus phage MMP7, complete genome) position: , mismatch: 1, identity: 0.972

cccccatactggtggatggccgcgtagcgcacgttg	CRISPR spacer
ccgccatactggtggatggccgcgtagcgcacgttg	Protospacer
** *********************************

38. spacer 4.4|333756|36|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to MH939157 (UNVERIFIED: Meiothermus phage MMP17, complete genome) position: , mismatch: 1, identity: 0.972

cccccatactggtggatggccgcgtagcgcacgttg	CRISPR spacer
ccgccatactggtggatggccgcgtagcgcacgttg	Protospacer
** *********************************

39. spacer 3.10|318991|35|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to MK071653 (Meiothermus phage MMP7, complete genome) position: , mismatch: 5, identity: 0.857

accaccaccgtgccgcccgcttcccataggtaggc	CRISPR spacer
acgataaccgtgccgccagcttcccacaggtaggc	Protospacer
** *. *********** ********.********

40. spacer 3.10|318991|35|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to MH939157 (UNVERIFIED: Meiothermus phage MMP17, complete genome) position: , mismatch: 5, identity: 0.857

accaccaccgtgccgcccgcttcccataggtaggc	CRISPR spacer
acgataaccgtgccgccagcttcccacaggtaggc	Protospacer
** *. *********** ********.********

41. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 6, identity: 0.812

gggagccccgacggctcggcggccac--ccaccg	CRISPR spacer
gcgagccccgacggcccggcgcccacgacgac--	Protospacer
* *************.***** ****  * **

42. spacer 4.2|333615|34|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to JX469828 (Uncultured bacterium plasmid pRSB223, complete sequence) position: , mismatch: 6, identity: 0.824

agcaaacgctcggtggcctgggtggcctccggcc	CRISPR spacer
cgcaaacgctcggcggcctgggcggcctcgcggc	Protospacer
 ************.********.******  * *

43. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_LR134454 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence) position: , mismatch: 7, identity: 0.781

gggagccccgacggctcggcggccacccaccg	CRISPR spacer
tcgtgccccgacggcgcggcgtccacccagag	Protospacer
  * *********** ***** *******  *

44. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.781

gggagccccgacggctcggcggccacccaccg	CRISPR spacer
tgccgccccgacggcatggcggccacccccgg	Protospacer
 *  *********** .*********** * *

45. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 7, identity: 0.781

gggagccccgacggctcggcggccacccaccg	CRISPR spacer
tgccgccccgacggcatggcggccacccccgg	Protospacer
 *  *********** .*********** * *

46. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP016560 (Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence) position: , mismatch: 7, identity: 0.781

gggagccccgacggctcggcggccacccaccg	CRISPR spacer
tgccgccccgacggcatggcggccacccccgg	Protospacer
 *  *********** .*********** * *

47. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP007795 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence) position: , mismatch: 7, identity: 0.781

gggagccccgacggctcggcggccacccaccg--	CRISPR spacer
ggcaggcccgacggctcggcggcga--aagcggt	Protospacer
** ** ***************** *   * **

48. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP032347 (Azospirillum brasilense strain MTCC4039 plasmid p2, complete sequence) position: , mismatch: 7, identity: 0.781

gggagccccgacggctcggcggccacccaccg--	CRISPR spacer
ggcaggcccgacggctcggcggcga--aagcggt	Protospacer
** ** ***************** *   * **

49. spacer 4.2|333615|34|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016617 (Microvirga ossetica strain V5/3m plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.794

agcaaacgctcggtggcctgggtggcctccggcc--	CRISPR spacer
agcaaacgcttggcggcctgggtg--ttgcggcgcg	Protospacer
**********.**.**********  .* ****

50. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.75

gggagccccgacggctcggcggccacccaccg	CRISPR spacer
ccgacgtccgacggctcggcgcccagccacct	Protospacer
  **  .************** *** *****

51. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP032323 (Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence) position: , mismatch: 8, identity: 0.75

gggagccccgacggctcggcggccacccaccg--	CRISPR spacer
ggcaggcccgacggctcggcggcga--aggcggt	Protospacer
** ** ***************** *   . **

52. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP032341 (Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence) position: , mismatch: 8, identity: 0.75

gggagccccgacggctcggcggccacccaccg--	CRISPR spacer
ggcaggcccgacggctcggcggcga--aggcggt	Protospacer
** ** ***************** *   . **

53. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP033321 (Azospirillum brasilense strain Cd plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.75

gggagccccgacggctcggcggccacccaccg--	CRISPR spacer
ggcaggcccgacggctcggcggcga--aggcggt	Protospacer
** ** ***************** *   . **

54. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP033315 (Azospirillum brasilense strain Sp 7 plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.75

gggagccccgacggctcggcggccacccaccg--	CRISPR spacer
ggcaggcccgacggctcggcggcga--aggcggt	Protospacer
** ** ***************** *   . **

55. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP012916 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence) position: , mismatch: 8, identity: 0.75

gggagccccgacggctcggcggccacccaccg--	CRISPR spacer
ggcaggcccgacggctcggcggcga--aggcggt	Protospacer
** ** ***************** *   . **

56. spacer 4.2|333615|34|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to MH271305 (Gordonia phage Morrissey, complete genome) position: , mismatch: 8, identity: 0.765

-agcaaacgctcggtggcctgggtggcctccggcc	CRISPR spacer
gtccgtacg-tcggcggcctgggtggcctcgggcg	Protospacer
   *. *** ****.*************** ***

57. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_AP022602 (Mycobacterium gallinarum strain JCM 6399 plasmid pJCM6399) position: , mismatch: 9, identity: 0.719

gggagccccgacggctcggcggccacccaccg	CRISPR spacer
gggatcgccgacggctcggcggccagtagaac	Protospacer
**** * ****************** . .

58. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP034710 (Salmonella enterica subsp. enterica serovar Karamoja strain RSE21 plasmid pRSE21, complete sequence) position: , mismatch: 9, identity: 0.719

gggagccccgacggctcggc------ggccacccaccg	CRISPR spacer
gggagccccgacggcgcggctgcagtggctgc------	Protospacer
*************** ****      ***..*

59. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NC_049470 (Arthrobacter phage TripleJ, complete genome) position: , mismatch: 9, identity: 0.719

gggagcc----ccgacggctcggcggccacccaccg	CRISPR spacer
----gtcccggccggcggctgggcggccacccacgt	Protospacer
    *.*    ***.***** *************

60. spacer 3.11|319062|37|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP029831 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence) position: , mismatch: 10, identity: 0.73

ggggcggctccgccgccagggagggggcgatatggcg	CRISPR spacer
tgcgcggctccgccgccagggcgcgggcgacgccgac	Protospacer
 * ****************** * ******... *

61. spacer 4.2|333615|34|NC_014213|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026221 (Aeromonas sp. ASNIH4 plasmid pAER-f909, complete sequence) position: , mismatch: 10, identity: 0.706

agcaaacgctcggtggcctgggtggcctccggcc	CRISPR spacer
ccgacgagctcggtgcccagggtggcctccgccg	Protospacer
   * . ******** ** ************ *

62. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 11, identity: 0.656

gggagccccgacggctcggcggccacccaccg	CRISPR spacer
aacgcccccggcggctccgcggccaccccgga	Protospacer
.. . *****.****** **********   .

63. spacer 3.8|318850|32|NC_014213|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 11, identity: 0.656

gggagccccgacggctcggcggccacccaccg	CRISPR spacer
aacgcccccggcggctccgcggccaccccgga	Protospacer
.. . *****.****** **********   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

36588 : 80653

Shigella_phage(22.22%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013156564.1\|36588_37620_+\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA
WP_013159579.1\|37764_39036_-	GGDEF domain-containing protein	A0A1B0Z064	Pseudomonas_phage	3.2e-09	43.0
WP_148225922.1\|39078_40202_-\|transposase	IS3-like element ISMesi1 family transposase	Q716C2	Shigella_phage	1.1e-26	31.6
WP_049777929.1\|40256_40631_+	ABC transporter permease	NA	NA	NA	NA
WP_169307901.1\|40747_41419_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_013159581.1\|41420_42347_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.2e-11	32.1
WP_169307902.1\|42417_42972_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	4.6e-13	34.3
WP_013159585.1\|45790_46054_+	hypothetical protein	NA	NA	NA	NA
WP_013159586.1\|46154_46553_+	DUF2384 domain-containing protein	NA	NA	NA	NA
WP_013159587.1\|46549_47050_+	RES domain-containing protein	NA	NA	NA	NA
WP_013159589.1\|47489_48224_-	2-phosphosulfolactate phosphatase	NA	NA	NA	NA
WP_013159590.1\|48248_49199_-	class II fructose-1,6-bisphosphate aldolase	NA	NA	NA	NA
WP_013159591.1\|49179_49854_-	ribulose-phosphate 3-epimerase	NA	NA	NA	NA
WP_013159592.1\|49846_50815_-	phosphoribulokinase	A0A2H4UUR3	Bodo_saltans_virus	2.3e-23	34.2
WP_013159593.1\|50804_51743_-	CbbX protein	G3MAX6	Bacillus_virus	7.7e-45	40.4
WP_013159594.1\|51752_52175_-	ribulose bisphosphate carboxylase small subunit	NA	NA	NA	NA
WP_013159595.1\|52185_53628_-	form I ribulose bisphosphate carboxylase large subunit	NA	NA	NA	NA
WP_013159596.1\|53637_54627_-	class II fructose-bisphosphatase	NA	NA	NA	NA
WP_013159597.1\|54717_55611_+	LysR family transcriptional regulator	Q6JIH3	Burkholderia_virus	5.7e-05	31.2
WP_013159598.1\|55607_56087_-	DinB family protein	NA	NA	NA	NA
WP_013159599.1\|56097_56376_-	hypothetical protein	NA	NA	NA	NA
WP_013159600.1\|56383_56671_-	hypothetical protein	NA	NA	NA	NA
WP_013159601.1\|56667_56964_-	Dabb family protein	NA	NA	NA	NA
WP_013159602.1\|56960_57713_-	HAD-IA family hydrolase	NA	NA	NA	NA
WP_013159603.1\|57709_59701_-	transketolase	NA	NA	NA	NA
WP_013159604.1\|59817_61182_-	DUF3422 domain-containing protein	NA	NA	NA	NA
WP_013156564.1\|61270_62302_+\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA
WP_013159605.1\|62569_62827_-	hypothetical protein	NA	NA	NA	NA
WP_013159606.1\|62877_63297_-	putative toxin-antitoxin system toxin component, PIN family	NA	NA	NA	NA
WP_013159607.1\|63293_63515_-	hypothetical protein	NA	NA	NA	NA
WP_013159608.1\|63691_63997_+	hypothetical protein	NA	NA	NA	NA
WP_083771738.1\|64317_64755_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_013159610.1\|64765_64942_-	hypothetical protein	NA	NA	NA	NA
WP_013159611.1\|65632_66196_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_148225922.1\|66263_67386_+\|transposase	IS3-like element ISMesi1 family transposase	Q716C2	Shigella_phage	1.1e-26	31.6
WP_013159612.1\|67531_68734_+	CoA transferase	NA	NA	NA	NA
WP_013159613.1\|68715_69501_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.1e-31	37.9
WP_013159614.1\|69487_70261_+	ABC transporter permease	NA	NA	NA	NA
WP_013159615.1\|70257_71256_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013159616.1\|71255_72074_+	hypothetical protein	NA	NA	NA	NA
WP_013159617.1\|72597_72750_+	hypothetical protein	NA	NA	NA	NA
WP_013159618.1\|73571_74015_-	PIN domain-containing protein	NA	NA	NA	NA
WP_013159619.1\|74011_74263_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_013159620.1\|74337_75423_-\|transposase	transposase	NA	NA	NA	NA
WP_013159621.1\|75774_76905_-	amidohydrolase family protein	NA	NA	NA	NA
WP_041653806.1\|76913_78245_-	glutamine synthetase	NA	NA	NA	NA
WP_013159623.1\|78261_79092_-	N-formylglutamate amidohydrolase	NA	NA	NA	NA
WP_013159624.1\|79088_79544_-	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_013156564.1\|79621_80653_-\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

118943 : 167765

uncultured_Mediterranean_phage(50.0%)

protease,transposase,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013159657.1\|118943_120029_+\|transposase	transposase	NA	NA	NA	NA
WP_013159658.1\|120120_121191_+	extracellular solute-binding protein	NA	NA	NA	NA
WP_013159659.1\|121203_122046_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_013159660.1\|122042_122801_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_013159661.1\|122800_123850_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.2e-30	36.2
WP_013156567.1\|125888_127151_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	7.4e-75	40.7
WP_148226090.1\|128039_128669_+	hypothetical protein	NA	NA	NA	NA
WP_013159664.1\|128744_129023_+	hypothetical protein	NA	NA	NA	NA
WP_013159665.1\|129053_130448_-	S8 family serine peptidase	A0A217EQY2	Bacillus_phage	2.8e-22	36.6
WP_013159666.1\|130529_130736_-	twin-arginine translocase TatA/TatE family subunit	NA	NA	NA	NA
WP_013159667.1\|130751_130973_-	hypothetical protein	NA	NA	NA	NA
WP_013159668.1\|131120_132596_-	DUF2867 domain-containing protein	NA	NA	NA	NA
WP_013159669.1\|132748_133825_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013159670.1\|134196_134868_-	diphthine--ammonia ligase	NA	NA	NA	NA
WP_013159671.1\|134884_136033_-	hypothetical protein	NA	NA	NA	NA
WP_013159673.1\|136523_137891_-	hypothetical protein	NA	NA	NA	NA
WP_013159674.1\|137906_138908_-	hypothetical protein	NA	NA	NA	NA
WP_013159675.1\|138904_140209_-\|tail	tail fiber domain-containing protein	NA	NA	NA	NA
WP_013159677.1\|141118_142522_-	replication initiator protein A	NA	NA	NA	NA
WP_013159678.1\|143202_145224_-	DEAD/DEAH box helicase	NA	NA	NA	NA
WP_013159679.1\|145234_150751_-	DEAD/DEAH box helicase	A0A1B1IUF6	uncultured_Mediterranean_phage	3.6e-89	24.6
WP_013159680.1\|150760_154777_-	N-6 DNA methylase	A0A1B1IUC6	uncultured_Mediterranean_phage	6.0e-46	26.8
WP_041653769.1\|154786_157537_-	DEAD/DEAH box helicase family protein	A0A1B1IUI1	uncultured_Mediterranean_phage	9.8e-64	31.2
WP_148226091.1\|157542_159072_-\|protease	BREX system Lon protease-like protein BrxL	NA	NA	NA	NA
WP_013156564.1\|159081_160113_-\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA
WP_013159683.1\|160233_162294_-	hypothetical protein	NA	NA	NA	NA
WP_041653835.1\|162297_165027_-	hypothetical protein	NA	NA	NA	NA
WP_049777934.1\|165069_166635_-	VWA domain-containing protein	NA	NA	NA	NA
WP_013156564.1\|166733_167765_-\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

297853 : 345349

Tupanvirus(14.29%)

integrase,transposase

attL 307731:307747|attR 343366:343382

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013156564.1\|297853_298885_+\|transposase	IS701-like element ISMesi2 family transposase	NA	NA	NA	NA
WP_013159769.1\|298898_299519_-	response regulator transcription factor	NA	NA	NA	NA
WP_049777944.1\|299531_301004_-	HAMP domain-containing histidine kinase	A0A2K9L0Z8	Tupanvirus	5.0e-06	32.1
WP_013159771.1\|301027_301360_-	hypothetical protein	NA	NA	NA	NA
WP_013159772.1\|301413_301617_-	hypothetical protein	NA	NA	NA	NA
WP_083771740.1\|301768_301849_+	potassium-transporting ATPase subunit F	NA	NA	NA	NA
WP_013159773.1\|301928_303638_+	potassium-transporting ATPase subunit KdpA	NA	NA	NA	NA
WP_013159774.1\|303634_305686_+	potassium-transporting ATPase subunit KdpB	E4ZFI9	Streptococcus_phage	6.2e-39	29.2
WP_013159775.1\|306899_307442_+	potassium-transporting ATPase subunit KdpC	NA	NA	NA	NA
WP_013159776.1\|307447_308560_+	sensor histidine kinase	NA	NA	NA	NA
307731:307747	attL	NA	NA	NA	NA
WP_013159777.1\|310401_311715_-	nitrate/sulfonate/bicarbonate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.1e-32	37.8
WP_013159778.1\|311744_313760_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_013159779.1\|314104_314410_-	helix-hairpin-helix domain-containing protein	NA	NA	NA	NA
WP_013159780.1\|314523_314913_-	hypothetical protein	NA	NA	NA	NA
WP_013159781.1\|315084_316179_+\|transposase	transposase	NA	NA	NA	NA
WP_013159782.1\|316197_316371_+	hypothetical protein	NA	NA	NA	NA
WP_041653779.1\|316465_317071_+	hypothetical protein	NA	NA	NA	NA
WP_041653780.1\|316980_317517_+	AAA family ATPase	NA	NA	NA	NA
WP_013159783.1\|317544_317919_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_013159784.1\|317899_318181_-	type II toxin-antitoxin system prevent-host-death family antitoxin	NA	NA	NA	NA
WP_013159785.1\|320098_320380_-	CRISPR-associated endonuclease Cas2	NA	NA	NA	NA
WP_013159786.1\|320389_321370_-	CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_013159787.1\|321369_321942_-	CRISPR-associated protein Cas4	NA	NA	NA	NA
WP_013159788.1\|322120_323089_+	WYL domain-containing protein	NA	NA	NA	NA
WP_013159789.1\|323324_325877_+	CRISPR-associated helicase/endonuclease Cas3	A0A2R2ZGW0	Clostridioides_phage	1.1e-05	25.9
WP_013159790.1\|325867_327259_+	hypothetical protein	NA	NA	NA	NA
WP_013159791.1\|327255_328263_+	DevR family CRISPR-associated autoregulator	NA	NA	NA	NA
WP_013159792.1\|328271_329021_+	hypothetical protein	NA	NA	NA	NA
WP_013159793.1\|329020_329827_+	CRISPR-associated endoribonuclease Cas6	NA	NA	NA	NA
WP_148225922.1\|330969_332093_-\|transposase	IS3-like element ISMesi1 family transposase	Q716C2	Shigella_phage	1.1e-26	31.6
WP_013159795.1\|332339_333428_+\|transposase	transposase	NA	NA	NA	NA
WP_013159796.1\|333991_334366_+	hypothetical protein	NA	NA	NA	NA
WP_083771749.1\|334728_334767_+	excalibur calcium-binding domain-containing protein	NA	NA	NA	NA
WP_013159797.1\|335296_335671_-	DUF433 domain-containing protein	NA	NA	NA	NA
WP_013159798.1\|336252_337020_-	hypothetical protein	NA	NA	NA	NA
WP_013159799.1\|337576_338401_-	aminotransferase class IV	NA	NA	NA	NA
WP_083771742.1\|338417_340493_-	chorismate-binding protein	A0A0P0IKJ1	Acinetobacter_phage	3.7e-31	38.4
WP_013159801.1\|340618_341563_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_013159802.1\|342448_342706_+	hypothetical protein	NA	NA	NA	NA
WP_083771743.1\|342769_343057_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_041653874.1\|343463_344264_+	alpha/beta hydrolase	W0LK50	Mycobacterium_phage	1.8e-05	30.3
343366:343382	attR	NA	NA	NA	NA
WP_041653782.1\|344479_345349_-\|transposase	transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NC_014213.1|WP_013159667.1|130751_130973_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_014213.1|WP_013159667.1|130751_130973_-|hypothetical-protein

130751_130973_-

73 aa aa

118943-167765

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_014212_6	Orphan	6.1\|3054269\|21\|NC_014212\|CRT	3054269-3054289	21	128695-128675	2
NC_014212_6	Orphan	6.2\|3054308\|21\|NC_014212\|CRT	3054308-3054328	21	128695-128675	2
NC_014212_6	Orphan	6.3\|3054347\|21\|NC_014212\|CRT	3054347-3054367	21	128695-128675	2

1. spacer 6.1|3054269|21|NC_014212|CRT matches to NC_014213 position: 128695-128675, mismatch: 2

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggagccgatagcc	Protospacer
**********.******.***

2. spacer 6.2|3054308|21|NC_014212|CRT matches to NC_014213 position: 128695-128675, mismatch: 2

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggagccgatagcc	Protospacer
**********.******.***

3. spacer 6.3|3054347|21|NC_014212|CRT matches to NC_014213 position: 128695-128675, mismatch: 2

gccagccgggggccgatggcc	CRISPR spacer
gccagccgggagccgatagcc	Protospacer
**********.******.***

3. NC_014214

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_014214_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014214_1

108855-109381

TypeV-U1

Consensus_repeat	Method
AGCCTCTGAGCTAGGCGTTGCTAC	CRISPRCasFinder

7 spacers

c2c4_V-U1

The CRISPR arrays of NC_014214_1

>merge|NC_014214|1|108855-109381|CRISPRCasFinder
AACCCCCGGGCAGGGCGTTGCTACACGAGCACGGTTTGAAGGTTGCTCGTCGTCTGCTATCTCAGCTTCTAATCCCCTGAGCAGGGCATTGCTACTGGCCACGGTGAGCTGCGTGTCCCAGAACCACATGTCTCAGCTTCCAAGCCTCTGAGCTAGGCATTGCTACGTATTATTGGTTACTTGCTACTGGGTGTTGTCTCAGTCTTCAAGCCCCTGAGCTAGGCATTGCTACAAATCGGTGGGCTCGCGCAGCGACGCGATCACCGTGTCTCAGCTTCTAAGCCTCTGAGCTAGGCGTTGCTACAGCCAGCCGCGTGAGCAGCACTTCCGGCTCGGGGGTGCTATGTCTCAGTTTTCGAGCCCCTGAGCTAGGCGTTGCTACCTTGGAAGCTGAGACAATGCCCTAAAACCGAAGTCTCAGTCTTCAGAGCCCCTGAGCAGGGTGTTGCTACTCCTAGCTAGGTAGATACCGATTGCAACATGTGAGTGTGTCTCAGTCATCAAACCCCCGAGCTAGGCGTTGCTAC

>NC_014214|1|1|108855-109381|CRISPRCasFinder
AACCCCCGGGCAGGGCGTTGCTAC	ACGAGCACGGTTTGAAGGTTGCTCGTCGTCTGCTATCTCAGCTTCTA
ATCCCCTGAGCAGGGCATTGCTAC	TGGCCACGGTGAGCTGCGTGTCCCAGAACCACATGTCTCAGCTTCCA
AGCCTCTGAGCTAGGCATTGCTAC	GTATTATTGGTTACTTGCTACTGGGTGTTGTCTCAGTCTTCA
AGCCCCTGAGCTAGGCATTGCTAC	AAATCGGTGGGCTCGCGCAGCGACGCGATCACCGTGTCTCAGCTTCTA
AGCCTCTGAGCTAGGCGTTGCTAC	AGCCAGCCGCGTGAGCAGCACTTCCGGCTCGGGGGTGCTATGTCTCAGTTTTCG
AGCCCCTGAGCTAGGCGTTGCTAC	CTTGGAAGCTGAGACAATGCCCTAAAACCGAAGTCTCAGTCTTCAG
AGCCCCTGAGCAGGGTGTTGCTAC	TCCTAGCTAGGTAGATACCGATTGCAACATGTGAGTGTGTCTCAGTCATCA
AACCCCCGAGCTAGGCGTTGCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014214.1\|WP_013159919.1\|118697_119408_-\|RNA-polymerase-subunit-sigma-28	unknown	unknown	gnl\|CDD\|377379
NC_014214.1\|WP_013159911.1\|109532_111143_-\|transposase	c2c4_V-U1	-	gnl\|CDD\|284650
NC_014214.1\|WP_013159910.1\|107602_108478_-\|DNA-adenine-methylase	unknown	unknown	gnl\|CDD\|223415
NC_014214.1\|WP_013159916.1\|115574_117500_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|273632
NC_014214.1\|WP_013159915.1\|113453_115475_-\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|224117
NC_014214.1\|WP_013159912.1\|111282_111669_-\|hypothetical-protein	unknown	unknown	unknown
NC_014214.1\|WP_041653911.1\|103931_104915_-\|hypothetical-protein	unknown	unknown	unknown
NC_014214.1\|WP_179943947.1\|104898_107136_-\|Eco57I-restriction-modification-methylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|380297
NC_014214.1\|WP_013159904.1\|97516_98083_-\|hypothetical-protein	unknown	unknown	unknown
NC_014214.1\|WP_013159917.1\|117483_117996_+\|hypothetical-protein	unknown	unknown	unknown
NC_014214.1\|WP_013159902.1\|94693_95623_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271175
NC_014214.1\|WP_013159907.1\|99720_103098_-\|helicase	unknown	unknown	gnl\|CDD\|197275
NC_014214.1\|WP_169307909.1\|113159_113435_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NC_014214.1\|WP_013159906.1\|98656_99718_-\|hypothetical-protein	unknown	unknown	unknown
NC_014214.1\|WP_013159914.1\|112523_112967_-\|hypothetical-protein	unknown	unknown	unknown
NC_014214.1\|WP_013159903.1\|95840_97415_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NC_014214.1\|WP_013159913.1\|111730_112486_-\|hypothetical-protein	unknown	unknown	unknown
NC_014214.1\|WP_013159905.1\|98276_98660_-\|hypothetical-protein	unknown	unknown	unknown
NC_014214.1\|WP_013159909.1\|107252_107570_-\|hypothetical-protein	unknown	unknown	unknown
NC_014214.1\|WP_013159918.1\|118024_118651_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014214.1\|WP_013159907.1\|99720_103098_-\|helicase	gnl\|CDD\|197275	cd09178, PLDc_N_Snf2_like, N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family. N-terminal putative catalytic domain of uncharacterized archaeal and prokaryotic HKD family nucleases fused to putative helicases from the Snf2-like family, which belong to the DNA/RNA helicase superfamily II (SF2). Although Snf2-like family enzymes do not possess helicase activity, they contain a helicase-like region, where seven helicase-related sequence motifs are found, similar to those in DEAD/DEAH box helicases, which represent the biggest family within the SF2 superfamily. In addition to the helicase-like region, members of this family also contain an N-terminal putative catalytic domain with one copy of the conserved HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue), and have been classified as members of the phospholipase D (PLD, EC 3.1.4.4) superfamily.	1.02861e-30
NC_014214.1\|WP_013159911.1\|109532_111143_-\|transposase	gnl\|CDD\|284650	pfam07282, OrfB_Zn_ribbon, Putative transposase DNA-binding domain. This putative domain is found at the C-terminus of a large number of transposase proteins. This domain contains four conserved cysteines suggestive of a zinc binding domain. Given the need for transposases to bind DNA as well as the large number of DNA-binding zinc fingers we hypothesize this domain is DNA-binding.	8.66428e-10
NC_014214.1\|WP_169307909.1\|113159_113435_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	2.02062e-16
NC_014214.1\|WP_013159916.1\|115574_117500_+\|AAA-family-ATPase	gnl\|CDD\|273632	TIGR01448, recD_rel, helicase, putative, RecD/TraA family. This model describes a family similar to RecD, the exodeoxyribonuclease V alpha chain of TIGR01447. Members of this family, however, are not found in a context of RecB and RecC and are longer by about 200 amino acids at the amino end. Chlamydia muridarum has both a member of this family and a RecD. [Unknown function, Enzymes of unknown specificity].	3.84546e-95
NC_014214.1\|WP_013159919.1\|118697_119408_-\|RNA-polymerase-subunit-sigma-28	gnl\|CDD\|377379	pfam04539, Sigma70_r3, Sigma-70 region 3. Region 3 forms a discrete compact three helical domain within the sigma-factor. Region is not normally involved in the recognition of promoter DNA, but as some specific bacterial promoters containing an extended -10 promoter element, residues within region 3 play an important role. Region 3 primarily is involved in binding the core RNA polymerase in the holoenzyme.	7.76993e-07
NC_014214.1\|WP_013159903.1\|95840_97415_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	2.32854e-54
NC_014214.1\|WP_013159910.1\|107602_108478_-\|DNA-adenine-methylase	gnl\|CDD\|223415	COG0338, Dam, Site-specific DNA methylase [DNA replication, recombination, and repair].	2.44503e-39
NC_014214.1\|WP_179943947.1\|104898_107136_-\|Eco57I-restriction-modification-methylase-domain-containing-protein	gnl\|CDD\|380297	NF033455, BREX_6_MTaseX, BREX-6 system adenine-specific DNA-methyltransferase PglX.	2.03582e-08
NC_014214.1\|WP_013159915.1\|113453_115475_-\|S-layer-homology-domain-containing-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	1.01226e-08
NC_014214.1\|WP_013159902.1\|94693_95623_-\|site-specific-integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	4.68815e-14

>NC_014214.1|WP_013159910.1|107602_108478_-|DNA-adenine-methylase
MGNAPEYKPINSPIKWVGGKSRLRKKIISLLPSHTCYVEVFGGAAWVLFGKPPSDVEVLNDIDGELINFFRVLRTRPEEFLASFEFELVSREEFQRLANLNPKQLSEIERAHRFYYLIMAGWGGELNYPRFQTSITDGGHGNRLIGALKYLKGRIRPVHERLKTVIIENLDWKECIERYDRPETVFYVDPPYPGNGVNYFHNMWGWEDHQELADRLIKAQGKWVLSSYDDPWVREMYKGFHVLSVQAYSGMRTKKDANSRVLNEEVLVMNFHLPAEALEKYGMAELFSEAP
>NC_014214.1|WP_013159909.1|107252_107570_-|hypothetical-protein
MGQTEKVTIYCYGGCGRSVTLQKSKVQKADYYICGSRESGAQCEARLPPLSPGKVRYAVINAAGSFWGYTDEWPDTETAASVMRAQEIRAAGLAQMDIEKDKSCN
>NC_014214.1|WP_179943947.1|104898_107136_-|Eco57I-restriction-modification-methylase-domain-containing-protein
MLLDEEVPVVALEVEQAAKKRRKDWEGAARYLLERGLSAGLFVFHDAYGAYRLSLVSARYRGKRKPELSDYRRHSLIAHPDQPNKTFFQQLHRMAENPPASLDELQAIFSVEAVSEAFYREFLGVFSNRLVEGVVGADSERQDFALAFVARTIFLGFVQRRGWLGGREDFLPYLYKRYAETVGVGARFYREWLEPLFFQALKAPPGSKRLADNLPPEVREALEQAPYLNGELFAPKPGLDDRGLYLRDQAIQAFFDFLFAHNFTVEENDRYEEELELNPEFLGLILERLINQLGVEGKSREAGAHYTPRVEVDLMCRLALAEHLYRQGLSFERAYALMGGWGGGLSPEEQARAREKLLEVRVLDPAVGSGAFLVGMLQTLEETLEALGEPRTLDLRKRLLQNLYGVDALGWAVWMAELRLWLAYFVELPDHARYSREPLLPSLGLKVAHGDSVVQTIGSTPVPAKLPTKAGGLRDEPIKRSYEALVAAKEDYFHNRGVNAERVEEQEKAFLLTYARQLLLGKGQEQGLLVEGAAERAEEDYRRLEALVALGRRPFFYLLDFAEVLLGPKGGFDIVIGNPPYVRQEEIQDLFGRHTAERYKALLREGAERDLDLVTGYREKARPKPSGRSDLYTYFYLRSLALLHPKGVQVFVTSNSWLDVQYGAWLQQVFLEAAPLRYVIENRVKRSFRADVNTVITVAHAADPEKKVPRDWPVLFVAVKRPFEESDLLHELFEAQTEVLRAGVA
>NC_014214.1|WP_041653911.1|103931_104915_-|hypothetical-protein
MQALRNSEKTRILAPTAGQLWEEGKDEKGRYAGGKWGGRYLRAPDIYFRVLQQAGDRLVRLGEVAEVRFGIKTGANDFFYLEVLPYRPVCPCCREVHPEALIKEEEAAYRERGEAPPEGALVAVRNEAGWEGYLEAGSLRPIIKSYREWADDPDRVPSPRLFVYAKGNHSDAYLRHGEETAIPLRTSVGARSPWWKLSPLTPPTAIVPAGVDREYLFLPNQKGFLIDKRLYGLFHVEPVVVRLMNTALFKLSLEVLVRTGLGGGLADFTVYEYKQGLLLNPKLLPDPDAEATDTQVAKILGLNDQERRELLLALEQLIRERVSRANT
>NC_014214.1|WP_013159907.1|99720_103098_-|helicase
MHFITNAREKKDLAARLADLSTASLELKFLVGFFYFSGWRELYEPLKKAAESNPNLKLKILVGLSVDRPAGRLLEVARKAEGTGQEVSWALLEEYAQALSDPSLDLEDFPEQARFFLRLLQEGRLEIRKTREPNHAKLYLFKVDAPQQRLLGSPGKFITGSSNLTHAGLRGQHEFNVEIGDYGFEEAEAYFDGLWSRAVPLRPEDIARLGEIIERGSLAALPTPFEVYALLLRRYLEVVEALPTRQGPAAYLQRIGYQALPYQLDAVELILRALQEYGGAILADVVGLGKTVVASLVAREYGGRGMVLAPPGLIGEEGRYGWLKYLADFGLHDWRAYSVGQLEEALDFLQGPGQDVELVVVDEAHRFRNPESQAYALLQAITAGRKTLLLSATPYNNYPLDVFALLRLFVTPGDSKVGPTADLEGYFRELTRAFKAYSYILRYHRARDPRKREKAERLYRDHFGDNPPVDERRVERGMAQIARKVRSAMAPVTVRRNRLDLEKDPRYREHLPAFSRLEDPKPLFYELTPDQSAFYDQVVEEWFGPEGAFRGSIYQPALYQEGLFGEEEVEDGSAEVVFALESQRNLADFMRRLLVRRFESSFGAFTRTVERLVEAHRMTLEFAQKTGYFILDRKSLEELLERMTAGEEALEIEEFMEALLQQDASAIQRGERSRERVYRLEEFRQRDLFLRHIENDLALLTQVYAQAARLQLADPQRDPKALALARFLRQSLEEEPGRKVVVFSEFVDTVEHLEQHLKGVGLRVLAVGRHLSGALMEQVVLDFDASLAEGLRRDRYDVLVTSDKLSEGVNLHRAGAVVNYDIPWNPTRVIQRVGRINRIGQRVFDALRIYHFFPTEKGSGVVDPRRVAEHKLFLIHKALGEDAKVLSPDEEPSPAQVYERLTHLPEEEESFDTWVRLEWERVQGMLPGLEERIARLPNRVKAARPGEAGALLVARKGLGFYAYAAKDASVQAVSFPEALNQARAEPATPRLDLSPEFWEVYQNLEQKLLQGDPEPFPSNSLEQKAARNLKTALEHYQKFGEEARVALIRALLRDILRYKRLPRYVLRRLIQVDLGQGGGAFRRFEGELQEIERRFAHIVLEEPRGGHAPELVVAVEWREGVAGKE
>NC_014214.1|WP_013159906.1|98656_99718_-|hypothetical-protein
MDKTRLHQILSLAQRAVREAREQIGEQAWQGLETALLSGERPWHEAVLLPLGLAQEMVLRDPDLRARLDRLQVAPGDLERISDLNLQACDLAALLPWNLTKGAYVFDPDLFRSLVGAPLERLPVDLLTRLPEYAPLLVFPEPWQGGVGAWVHLDVDTRFAPAHLEFRAVLLGENGRRLPLLLDLTGATLEECIQGTQTETLLSQQLVGMEGVSFPAAAFDTVRGLLNLALYLASEEPDLSGRPRPLPGVGQRRKDKPPRVYPEPDPLRIEVGWRIGAALRRARQAEARGQGGAGKSPQPHIRRAHWHLYWTGEGSRKDPSKARPKVRWIEPTLVGADRLEGELPAVVRIVEEP
>NC_014214.1|WP_013159905.1|98276_98660_-|hypothetical-protein
MTLEECQKEMEQWRSLPLERLAYLMGYAKALDPLHRPAEEIWQRVLPEHQRLDRHFSRGAADALEEVMFPRLLAAGVLAERIRQAMRALESTDFLLWVHAQLDSELAGRYPKRLARIAARLGRRAEA
>NC_014214.1|WP_013159904.1|97516_98083_-|hypothetical-protein
MKKTVLLILSALLLGACAPRTTTQPAEAPKQQDRYSVKSMMEAFLAPVLEGNIDYMLADENRECYGIIEGSSANGFRLKQLLADPQKRDAVLDALRKSAQDVKSRIYGSEIKESEEIQSAPPRPNMLYTVRLYARVYSYPQDENRSFSIMTELDGPRARLCAVKDVSRNGLIDLYQPYIFGVVNKYGK
>NC_014214.1|WP_013159903.1|95840_97415_+|DEAD/DEAH-box-helicase
MESTRPPSPALLPLHRVQQQALEQVLSLYESGHSRQLVVMATGVGKTLWSVHLSRHFRRTLFLVHFEELLQQSLAAFRRRGGEPGVIWGRRTDLEADVVVGMIPSLVHRLERVPPERFDLVVVDEAHHARSRTWERVIRHFRPRLLVGLSATPYRTDGRSLLSLFDTLAFSYRLPEAVRDGFLVEPKILEVSTDQPLSIGRRGADYDEAQLSHAVDTPERNALLVRTVGEFARNRKGVVYAAGVRHAEHLAALFRSQGIAAESVYGEDPKRREKLERHRRGEFQVLTNAMLLVESYDDPTINLGVMGRPTASPTLYEQALGRPARLLREGRAWDGTPKTDYLWIDLMDLGLEDRVRVWEFFGVHTVWHDEKRPPRIRTLREPPTRQEAAAAAHAELPPQLRANIPLSRYLAWVERLQAPPPFVLEDEVERLWRRQPATEAQLALLAAHGYDVQDTSWTKGDASEVIEGLEPTPRQKARLLALGYDTLTRRWTRRQAQQAFREAEAQGIQPDWNRVRGLAPHWLS
>NC_014214.1|WP_013159902.1|94693_95623_-|site-specific-integrase
MLLSASPLDDPATRRAYLEAALAAWDSEALLEAVVYAHRLFGWRETVTVAVTRNLVYWLREQGYLWPRLPQNALLRFWQLCTEERPPLSPRPIRKNSSQYAWWRGLRRFWDTLRWGGVELPRLEMPPKPRYALIRPYFSDAEFARLVEGARSHPEGRLRRLGVAVLYLLGEAGVWPRELFALRLEDFQPAARVLRVRGEKARSVPLSKEATEALKAYLEDRESVAGLAPLPSPYLLLRMTPKKGGLGRPLNRDTLKGLLERALEMGGLEHPRPTGALRWRAVRRYLQQGLSPQEVARRTGVASVLSLKD
>NC_014214.1|WP_013159911.1|109532_111143_-|transposase
MPFGKKARHVKAYQFGADAPQEGMEAVLEQHRLRTDYYNALVEMELRQREERTALLANLAAESGLESPNQVYERLKAAGEKGIRKHPEYVAARERQKALYGHPRLLELQSRQREERNALRRSFGAKGLYSSNYLDVERAFDKARQSPELRFRRYSPHEGRLAVLYTEGLPMREIGSDTRVQLPLPDPIIYRDRATRRKHQRVLMKFRVRSVERQPLWITVPVYLHRELPDGVCREVSLHWHRVADRLRWTVSVVVEVEGPPVASPTGRGAVAVDLGWRRVEGGLRAGFWVGEDGAGGEIALSEGDLKQFSKVEDLRSIRDQHLNALKEALAAWLEAPPAPLPDWLAEETKTLPQWRSPARFAALFRRWQSERVHADEAAYGLLEGWHKRDRHLWQYEANLREQMILRRREQYRVLAATLARQYDALIVEDFNLRAAAELDQGGSDLPDAARRYRTIASPSTLRDALVNAFAQRGKPVRKLNPAHTTTDCHACGGALVGDPAKELRLYCPTCERFYDQDENAARNLLRRAQEVQAQV
>NC_014214.1|WP_013159912.1|111282_111669_-|hypothetical-protein
METWHKAWILSGIIFRQCQAAQARLGKGRGSHLEAIAQRLYKLQAAEALVRLALAGALDEEGALPAPLAAGPKERALVEAAGLEGDSHDPAALAYLVAWLADQGDPEAGRHLAQGFLARFPGHRIRSD
>NC_014214.1|WP_013159913.1|111730_112486_-|hypothetical-protein
MEIRYTLKPHELPALSQRDLRHGVPALHPQGPAVRFTVNGRSVYVLLSTHPELIPLVEAYRAHQEAEEAQRQARREAVLAACPVDHVPAEQVWANGDLCRAKYRLLPSGQEVLGPDTLTPAGEGIYYLPLEWAGEALAQAEEERRRQEWLNEPIPPEALADYQRWAGLPTLEEMAAYWAQSPWLAEWGARIEHQHPSLKVDPNDRIPIPDYALRAYRRYGGDPERAWEAGDEEAWGILREWGGLIAKRTRK
>NC_014214.1|WP_013159914.1|112523_112967_-|hypothetical-protein
MIRVGSAFLPDSFAGRSLRERTRKGYGPTAVASRDLERYYALLAEARRRLRGRFGANELEALAFALQSMAEIEHPQLFVLAPESVEESVRYEELCAAGGIEDCADFLQRVRSLGVGELWALIDAVGIYLHLPDEERGAAGWKRLGLL
>NC_014214.1|WP_169307909.1|113159_113435_-|RDD-family-protein
MLPTACSGQTLGKRLMGIKVINAQGRAPGYGPAAMREVLGKILSALPLYLGYLVAVFHPEKRALHDLIGGTWVVVARSPAPVLSETPESPR
>NC_014214.1|WP_013159915.1|113453_115475_-|S-layer-homology-domain-containing-protein
MRRLLLLLTVLGGAALAQFSDVPAGHWAQEAIRRLTEQGLLSGYPDGRFAGQGTLTRYEAALLIYRLMQHLEADRVSQEDLEVLSKAILELQGELARLGVAVEAKLERGDLAEIERKLALLEARQAGLDPAALEDLKARLEEVALTATQALNQSTLALERLSGLSDRLDEVGQALQRLEEGQARQGQGAASDLAALRRETEALKRALEEVRQTPSPGSDPQLAVEVLAQQKRLEELQGRLERLAKEQAARMEAQEARLRALEEAERPRFSLESSLAWRQGYGYALGEEGPRVGGERVLGQLSIRGEREGKKFGLLLYSGGGVGYTAAGLEARLGEFQARSVWANGGEYGYRLGYRIGDDQTYLSLSGFLASPNLPAWLSRPVVEAQVEGQWRVNFADFSRLSLAAVYGREAGGKAESGYLLAMASDCALERQVLGGGLGLDLPLGYQGWLRYSQTEERTPAGCPNPLRLSRPVVEARLSSQGFLTSDFSYRREGYGGEGLGQTFTRNVLEGEVGFRFAFGQAQLVPVLGYSRIWFSDVQGSGGVWSSTEVDYPDRGDRQTWRFRLGWSGRFDPLQVEAEGLWRNTRYSSYIAAQYGGKAALVWRWDRARLSLEGGYYTGNNVDFLRFDPLDTPGVSNSLGWVGLRLGWESGEVSYGSDSAGGVRFGLRYGLQF
>NC_014214.1|WP_013159916.1|115574_117500_+|AAA-family-ATPase
MHAVSQARIEREVYRKGRFAVLEVELQGRRVRLAGELPPLLPGSCIEGVFTPFSHPRYGLTYRVEDLREVRSLPEARAWLAERLNLQKAPDPATALQALREGPGVLEGLTPPALKRWLTLAWPQIQAEWRLVQRGLSPESARLLWRVPPDSLEANPYPYLLEGLTRAEADHLARRHGREGLAPQGQILEELLEQARQGHTFPPYPHPLPEAARPLLDTLLYREPGRLGLTRYVQAEQAIARFFRRRPAPLRLAPPPAGLTQEQRQLWPRVEEGHALLTGGPGTGKSYTCAALLEAAHRARLEVVLLAPTGKAAVRLSELADHQAHTIHARLGWDGERFAHGPHHPLSADLVVVDEASMADVELLAALVAALSPHTHLLLVGDADQLPPVGPGAPFQDLLRGPTPQVRLTQLQRRAREHPVTRLSYQFRAGQLEPPHSEEGLSWRLGETSQVLQWLLEDTQRLWGKTRFQVLAPVYRGPLGIEALNRVLKERLNPGGYPDWRLGGLPVAPGDPLIQLRNDYALGLANGQLMEVQSADAQSLLVRLDDGSYKPIPRSQSRHLRHAFAISIHRSQGSQWPCVLLVVSREHGAFVNREMLYTGLTRSQHSAILYGQLEAYRDALARRASGRQTWLSQGGSHDRIP
>NC_014214.1|WP_013159917.1|117483_117996_+|hypothetical-protein
MTVSRDLLHALLSPTPPTHSRAVLEEAILLALAAGDHNAAHILLLALEHLKPRQRWQVAAQLEAQHMGLSPQEAIQLALGEARRYLGGRSYRRYASRRFRKGLSEYLASLPLEEEQRMRSYRSICKLTTAEIHLAERVLARCKKRWKNPLTAYRAFDTFLLALLEAHHRG
>NC_014214.1|WP_013159918.1|118024_118651_+|hypothetical-protein
MNEEKAREMARSIIAEVKEEIARLTARVRTGVVPDLERLTQALQTYRAGRYVTHPAVWPKGKYSYDYTLVEVAWQDEEWTVAVSRSSTVIPLSRTEGVFPPPTADYLVRRDGNLVMKDKLLRKDPESGVYLCGDYHPPQEILQVAAAGPYRVEVYRTVVNVRPDTHPLVLCHNEPDRRVKLRHGRQEARVSLEGGQLLSQFVLWRMLE
>NC_014214.1|WP_013159919.1|118697_119408_-|RNA-polymerase-subunit-sigma-28
MDAIRLMVGGFRVLSREMVMRNYVAFKHGDGQAFEALVAHYGYLAFEKAFRLFHRLGDEARDLAQELHWEVVEVLKKPLPNSSKNLTFWVHVALERKLREYVTQDGAGTYRENRLLQKLVAVRLELEGEKGRAPTPPELAEALGVDGATLERLLYLDEANRILSLSSPHPETGTQLEDMVASEEEVLADLEEALEKARLGLRPEELSTLDRFLAGEEVDQGALDALAATLKARMAA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Identity
NC_014214_1	1.1\|108879\|47\|NC_014214\|CRISPRCasFinder	108879-108925	47	NC_014214	Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence	108879-108925	1.0
NC_014214_1	1.2\|108950\|47\|NC_014214\|CRISPRCasFinder	108950-108996	47	NC_014214	Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence	108950-108996	1.0
NC_014214_1	1.3\|109021\|42\|NC_014214\|CRISPRCasFinder	109021-109062	42	NC_014214	Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence	109021-109062	1.0
NC_014214_1	1.4\|109087\|48\|NC_014214\|CRISPRCasFinder	109087-109134	48	NC_014214	Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence	109087-109134	1.0
NC_014214_1	1.5\|109159\|54\|NC_014214\|CRISPRCasFinder	109159-109212	54	NC_014214	Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence	109159-109212	1.0
NC_014214_1	1.6\|109237\|46\|NC_014214\|CRISPRCasFinder	109237-109282	46	NC_014214	Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence	109237-109282	1.0
NC_014214_1	1.7\|109307\|51\|NC_014214\|CRISPRCasFinder	109307-109357	51	NC_014214	Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence	109307-109357	1.0

1. spacer 1.1|108879|47|NC_014214|CRISPRCasFinder matches to NC_014214 (Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence) position: , mismatch: 0, identity: 1.0

acgagcacggtttgaaggttgctcgtcgtctgctatctcagcttcta	CRISPR spacer
acgagcacggtttgaaggttgctcgtcgtctgctatctcagcttcta	Protospacer
***********************************************

2. spacer 1.2|108950|47|NC_014214|CRISPRCasFinder matches to NC_014214 (Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence) position: , mismatch: 0, identity: 1.0

tggccacggtgagctgcgtgtcccagaaccacatgtctcagcttcca	CRISPR spacer
tggccacggtgagctgcgtgtcccagaaccacatgtctcagcttcca	Protospacer
***********************************************

3. spacer 1.3|109021|42|NC_014214|CRISPRCasFinder matches to NC_014214 (Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence) position: , mismatch: 0, identity: 1.0

gtattattggttacttgctactgggtgttgtctcagtcttca	CRISPR spacer
gtattattggttacttgctactgggtgttgtctcagtcttca	Protospacer
******************************************

4. spacer 1.4|109087|48|NC_014214|CRISPRCasFinder matches to NC_014214 (Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence) position: , mismatch: 0, identity: 1.0

aaatcggtgggctcgcgcagcgacgcgatcaccgtgtctcagcttcta	CRISPR spacer
aaatcggtgggctcgcgcagcgacgcgatcaccgtgtctcagcttcta	Protospacer
************************************************

5. spacer 1.5|109159|54|NC_014214|CRISPRCasFinder matches to NC_014214 (Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence) position: , mismatch: 0, identity: 1.0

agccagccgcgtgagcagcacttccggctcgggggtgctatgtctcagttttcg	CRISPR spacer
agccagccgcgtgagcagcacttccggctcgggggtgctatgtctcagttttcg	Protospacer
******************************************************

6. spacer 1.6|109237|46|NC_014214|CRISPRCasFinder matches to NC_014214 (Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence) position: , mismatch: 0, identity: 1.0

cttggaagctgagacaatgccctaaaaccgaagtctcagtcttcag	CRISPR spacer
cttggaagctgagacaatgccctaaaaccgaagtctcagtcttcag	Protospacer
**********************************************

7. spacer 1.7|109307|51|NC_014214|CRISPRCasFinder matches to NC_014214 (Meiothermus silvanus DSM 9946 plasmid pMESIL02, complete sequence) position: , mismatch: 0, identity: 1.0

tcctagctaggtagataccgattgcaacatgtgagtgtgtctcagtcatca	CRISPR spacer
tcctagctaggtagataccgattgcaacatgtgagtgtgtctcagtcatca	Protospacer
***************************************************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

4113 : 32998

Thermus_phage(15.38%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013157086.1\|4113_5241_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1P8DJG9	Virus_Rctr71	1.2e-79	46.2
WP_148226104.1\|5593_6109_-	hypothetical protein	NA	NA	NA	NA
WP_013159811.1\|6191_6767_+	hypothetical protein	NA	NA	NA	NA
WP_013159812.1\|6763_7729_-	ribonuclease H family protein	A0A0M4JP20	Mollivirus	2.8e-05	41.4
WP_013159813.1\|7715_9188_-	ParB/RepB/Spo0J family partition protein	G8DH78	Emiliania_huxleyi_virus	1.7e-09	29.9
WP_013159814.1\|9233_9746_-	RAD52/22 double-strand break repair protein	A0A191ZDG3	Pseudoalteromonas_virus	5.7e-18	44.1
WP_013159815.1\|9809_10106_-	hypothetical protein	NA	NA	NA	NA
WP_013159816.1\|10099_10315_-	hypothetical protein	NA	NA	NA	NA
WP_169307906.1\|10719_10923_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013159819.1\|10984_11386_-	hypothetical protein	NA	NA	NA	NA
WP_013159820.1\|11386_11566_-	hypothetical protein	NA	NA	NA	NA
WP_013159821.1\|11662_11815_-	hypothetical protein	NA	NA	NA	NA
WP_013159822.1\|11880_12117_-	hypothetical protein	NA	NA	NA	NA
WP_013159823.1\|12287_12509_-	hypothetical protein	NA	NA	NA	NA
WP_013159824.1\|12520_12682_-	hypothetical protein	NA	NA	NA	NA
WP_148226117.1\|12736_13093_-	hypothetical protein	NA	NA	NA	NA
WP_013159826.1\|13140_13950_-	DeoR family transcriptional regulator	A0A1L4BKI0	Thermus_phage	2.0e-09	36.2
WP_013159827.1\|14091_15093_-	ParB N-terminal domain-containing protein	NA	NA	NA	NA
WP_049777953.1\|15183_15858_+	hypothetical protein	NA	NA	NA	NA
WP_013159829.1\|16012_16153_-	hypothetical protein	NA	NA	NA	NA
WP_148226118.1\|16324_17599_-	hypothetical protein	A0A2I7R0P0	Vibrio_phage	1.2e-08	21.8
WP_049777954.1\|17790_18471_-	single-stranded DNA-binding protein	A0A2I7RK19	Vibrio_phage	1.5e-05	35.6
WP_083771751.1\|18476_19355_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_013159832.1\|19459_20089_-	PD-(D/E)XK nuclease family protein	A0MN44	Thermus_phage	1.4e-26	32.4
WP_013159833.1\|20098_20575_-	lytic transglycosylase domain-containing protein	A0A0S2SXL7	Bacillus_phage	1.5e-20	47.2
WP_013159834.1\|20615_21017_+	hypothetical protein	NA	NA	NA	NA
WP_013159835.1\|21107_21875_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_148226105.1\|21892_23596_+	EAL domain-containing protein	NA	NA	NA	NA
WP_013159837.1\|23588_24023_-	hypothetical protein	NA	NA	NA	NA
WP_041653892.1\|24019_24625_-	hypothetical protein	NA	NA	NA	NA
WP_148226106.1\|24692_25550_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_049777955.1\|25621_26695_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A0P0IJS6	Lactobacillus_phage	1.7e-19	30.8
WP_013159839.1\|26823_27027_+	hypothetical protein	NA	NA	NA	NA
WP_013159840.1\|27161_29102_-	UvrD-helicase domain-containing protein	A7KV33	Bacillus_phage	2.7e-76	33.3
WP_013159841.1\|29338_29755_+	hypothetical protein	NA	NA	NA	NA
WP_148226107.1\|29830_30184_+	DUF2227 family putative metal-binding protein	NA	NA	NA	NA
WP_049777956.1\|30236_30479_-	hypothetical protein	NA	NA	NA	NA
WP_049777957.1\|30469_31375_-	AAA family ATPase	H6WG28	Cyanophage	2.7e-10	26.5
WP_049777958.1\|31437_32649_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA
WP_148226109.1\|32605_32998_-\|transposase	IS200/IS605 family transposase	I4AZI8	Saccharomonospora_phage	8.2e-49	66.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014212

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_014213

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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3. NC_014214

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection