CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_008054	Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, complete genome	3 crisprs	cas3,DEDDh,cas8e,cse2gr11,cas7,cas5,cas6e,cas1,DinG,csa3,cas14j,c2c9_V-U4,WYL	1	10	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_008054_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008054_1

696702-696828

Orphan

Consensus_repeat	Method
CTGAGGCTAGAGCCGGTGAAGTTGACCCGGAGGCCGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008054_1

>merge|NC_008054|1|696702-696828|CRISPRCasFinder
CTGAGGCTAGAGCCGGTGAAGTTGACCCGGAGGCCGTTTGGGCCGGGCTGAGGATTCTACCTAAGCGCTCAGCTCCTTCATCGATCTGACTGAGGCTAGAGCCGGTGAAGTTGACCCGGAGGCCGTT

>NC_008054|1|1|696702-696828|CRISPRCasFinder
CTGAGGCTAGAGCCGGTGAAGTTGACCCGGAGGCCGTT	TGGGCCGGGCTGAGGATTCTACCTAAGCGCTCAGCTCCTTCATCGATCTGA
CTGAGGCTAGAGCCGGTGAAGTTGACCCGGAGGCCGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008054.1\|WP_003619763.1\|698065_698980_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_008054.1\|WP_014564789.1\|696001_696400_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-methyltransferase	unknown	unknown	gnl\|CDD\|180601
NC_008054.1\|WP_003619777.1\|706771_707710_-\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239113
NC_008054.1\|WP_003619769.1\|701616_702816_+\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	unknown	unknown	gnl\|CDD\|235513
NC_008054.1\|WP_002879191.1\|701131_701605_+\|arginine-repressor	unknown	unknown	gnl\|CDD\|224355
NC_008054.1\|WP_011543802.1\|709854_711177_+\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237046
NC_008054.1\|WP_041806442.1\|703920_704871_+\|2-hydroxyacid-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|240655
NC_008054.1\|WP_041806440.1\|682592_683468_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NC_008054.1\|WP_003624246.1\|699214_700912_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|183534
NC_008054.1\|WP_003619258.1\|679270_679759_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NC_008054.1\|WP_003619256.1\|678300_679257_+\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|213790
NC_008054.1\|WP_011543801.1\|704945_706715_+\|DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|273594
NC_008054.1\|WP_003623587.1\|685392_686790_+\|flavocytochrome-c	unknown	unknown	gnl\|CDD\|180584
NC_008054.1\|WP_003612584.1\|676856_677234_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215640
NC_008054.1\|WP_003619266.1\|684556_685270_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NC_008054.1\|WP_011543799.1\|702944_703919_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NC_008054.1\|WP_011543797.1\|694454_695678_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_008054.1\|WP_003619264.1\|683504_684560_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NC_008054.1\|WP_003619779.1\|707983_709786_+\|excinuclease-ABC-subunit-UvrC	unknown	unknown	gnl\|CDD\|234792
NC_008054.1\|WP_011543795.1\|675147_676797_+\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173869

Protein	Function_ID	Function_description	E-value
NC_008054.1\|WP_003619763.1\|698065_698980_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	6.80923e-46
NC_008054.1\|WP_014564789.1\|696001_696400_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-methyltransferase	gnl\|CDD\|180601	PRK06520, PRK06520, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.	1.62925e-36
NC_008054.1\|WP_003619777.1\|706771_707710_-\|nucleoside-hydrolase	gnl\|CDD\|239113	cd02647, nuc_hydro_TvIAG, nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. Nucleoside hydrolases vary in their substrate specificity. This group contains eukaryotic and bacterial proteins similar to the purine specific inosine-adenosine-guanosine-preferring nucleoside hydrolase (IAG-NH) from T. vivax. T. vivax IAG-NH is of the order of a thousand to ten thousand fold more specific towards the naturally occurring purine nucleosides, than towards the pyrimidine nucleosides. .	8.3752e-142
NC_008054.1\|WP_003619769.1\|701616_702816_+\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	gnl\|CDD\|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	1.52893e-169
NC_008054.1\|WP_002879191.1\|701131_701605_+\|arginine-repressor	gnl\|CDD\|224355	COG1438, ArgR, Arginine repressor [Transcription].	2.54214e-36
NC_008054.1\|WP_011543802.1\|709854_711177_+\|GTPase-ObgE	gnl\|CDD\|237046	PRK12297, obgE, GTPase CgtA; Reviewed.	0
NC_008054.1\|WP_041806442.1\|703920_704871_+\|2-hydroxyacid-dehydrogenase-family-protein	gnl\|CDD\|240655	cd12178, 2-Hacid_dh_13, Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	2.85704e-169
NC_008054.1\|WP_041806440.1\|682592_683468_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	1.15219e-94
NC_008054.1\|WP_003624246.1\|699214_700912_+\|arginine--tRNA-ligase	gnl\|CDD\|183534	PRK12451, PRK12451, arginyl-tRNA synthetase; Reviewed.	0
NC_008054.1\|WP_003619258.1\|679270_679759_+\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	6.78187e-80
NC_008054.1\|WP_003619256.1\|678300_679257_+\|thymidylate-synthase	gnl\|CDD\|213790	TIGR03284, thym_sym, thymidylate synthase. Members of this protein family are thymidylate synthase, an enzyme that produces dTMP from dUMP. In prokaryotes, its gene usually is found close to that for dihydrofolate reductase, and in some systems the two enzymes are found as a fusion protein. This model excludes a set of related proteins (TIGR03283) that appears to replace this family in archaeal methanogens, where tetrahydrofolate is replaced by tetrahydromethanopterin. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	0
NC_008054.1\|WP_011543801.1\|704945_706715_+\|DNA-helicase-RecQ	gnl\|CDD\|273594	TIGR01389, recQ, ATP-dependent DNA helicase RecQ. The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_008054.1\|WP_003623587.1\|685392_686790_+\|flavocytochrome-c	gnl\|CDD\|180584	PRK06481, PRK06481, flavocytochrome c.	0
NC_008054.1\|WP_003612584.1\|676856_677234_-\|hypothetical-protein	gnl\|CDD\|215640	PLN03232, PLN03232, ABC transporter C family member; Provisional.	0.00459665
NC_008054.1\|WP_003619266.1\|684556_685270_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	1.39608e-87
NC_008054.1\|WP_011543799.1\|702944_703919_+\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	3.00808e-25
NC_008054.1\|WP_011543797.1\|694454_695678_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	4.54591e-32
NC_008054.1\|WP_003619264.1\|683504_684560_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	6.10644e-145
NC_008054.1\|WP_003619779.1\|707983_709786_+\|excinuclease-ABC-subunit-UvrC	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
NC_008054.1\|WP_011543795.1\|675147_676797_+\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173869	cd08504, PBP2_OppA, The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding component of an ATP-binding cassette (ABC)-type oligopeptide transport system comprised of 5 subunits. The transport system OppABCDEF contains two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0

>NC_008054.1|WP_014564789.1|696001_696400_-|5-methyltetrahydropteroyltriglutamate---homocysteine-methyltransferase
MDITLHFCQGNLRSKKFYDAKYDGLVDTIFQLPFSGFFMEFDDEKYCNFSLLEKRQGQKIVLGLVNTQSDELEDKEVLLKRLEEANKHVDPKQICIATQCGFASTEAGNLISEEGQWRKLDLVHELAESLNA
>NC_008054.1|WP_011543797.1|694454_695678_-|IS110-family-transposase
MDLLKTVFGIDVSSRKSNVCIMVNGQKVNDYAISNDMVGFNRLLGDLKQVTKPQIIFEATGVYSRRLQAFLDMHELRYVMMNPLEAKRKTKDDLHQNKTDKLDALYLAKLQSEHPQRLAYVQNKEYQELMANNRIYEQASHDLITNRNRLHKAIQLTFPEIEHLMVNPRGKNYWSIALRFPHPDIVLETKEADIIDFLKGLSGIGKKRANDITQNLIRLAKVACPAVKKNSSHIRGLKMAINNILSAEEECQTALQEMAKLAPKRDLEILTSIPGIGENTALRIISELGDIRRFNNPSQLNAFVGVDPQVYESGNLTAHLSISKRGTAIGRKVLYLAINQIQSAKKVGNPCHIADYYEKRKRSSETASHKKAAIASIHKLLRTIFALIKNDQLYSYDVAKHNQRLLS
>NC_008054.1|WP_003623587.1|685392_686790_+|flavocytochrome-c
MAKYEFKSSPIDLVNPSYDLVVIGAGGTGLSAALQAHELGASVAVFEKNEVLGGNTSKASSGMNAAESLVQFKHGIIDNKADFYQETLKGGGNLNDEAMLSYFVDHAALAIDWLKQYGVELDDLTITGGMSKKRAHRPASMAPVGGYLITGLLKSIEAARIPVFNKTKVVKVLQDEKGKVTGIDIVGPDGRRKVMAKAVILATGGFGASKEIIKKYRPDLEGYKTTNQAGATGDGLILGEEAGAELVQMDFIQVHPTAQTDGEKTFLIGEAVRGEGAILVNKAGQRFINELDTRKVVSAAITGLNEDGAYLIFDQGVRDHVKAVEFYDHIGLVEHGATLEELAGKIGVDAAGLEATVASWNEAVKGQDDQAFGRTTGMDRDISVAPYFAIHIHPAIHYTMGGLHINPETQVLGKDDKVIEGLYAAGEVSGGLHGNNRIGGNSVAETVVFGRQAGIQASKFVRGEN
>NC_008054.1|WP_003619266.1|684556_685270_+|ABC-transporter-permease
MINGLVHWIAQNFPNIYNLGWTGDTGWGTSVLQIIYMTFWPSIFGGVLGLFFGVILVLTEPGGILENKFWFNFCDKLISILRAIPFIILLAFISPLTRLIVGTEIGDTAALVPLTLGIFPFYARQVQVALESLDPGKVEAAQSLGASNWDIIFDVYLKETRSEIIRVSTVSIISLIGLTAMAGAVGAGGLGTTAIQYGYRDFANDVTFLATVLVVIMIFIVQVVGDFLAKKLNHQHR
>NC_008054.1|WP_003619264.1|683504_684560_+|methionine-ABC-transporter-ATP-binding-protein
MSIVQLDHVSVTFKRKKAADVQAVQDVTLHIEKGDIYGIVGFSGAGKSTLVRTINLLQKPTAGDVVVGGVDFVKDGKQVISGKDLQARRRKIGMIFQQFNLLNETTVIENIAFALKHSDLSDDELEEKCHKLLKLVDLEDKANAYPAQLSGGQQQRVAIARALANDPEILLSDEATSALDPQTTIQILDLLKKLNRELGLTIVLITHEMAAVKKIANKVAVMENGRVVENGNLRDVFLAPKAELTQKFVGGSLAVVDTLKSLNISLAENEALYQLVYSLNNVAKSIIIELYREVGVEASMLYGNVEVLADEPVGTLLVMVKGDADKQKATLKFLSDEGVTVTELDERGNRL
>NC_008054.1|WP_041806440.1|682592_683468_+|ABC-transporter-substrate-binding-protein
MNHEKKETKKQRNIIIAIVAVVVLAVIAFFSFGKKGSQQSAKTVTVTVGTVGATKAERAIWKSVAATAKKKYGIIVKTKNFSDYNQPNSALKSGDLDLNAFQHYNFLNNWNKANKSNLVAIGKTYIAPIRLYSLKYKSLKSLPKGATIAIPNDTTNEARALLVLKNAGLITLKGTSATKLYSVADIKNNPKNFKIKEVATEQAARVLKSVDAAVVNNDYANPAGLGDKQTIYVEPINKDSYQWINVIVARKKDKNKKAYKEVVKAYQTEKTKQLYKKYYGIKQVAAWDAKF
>NC_008054.1|WP_003619258.1|679270_679759_+|dihydrofolate-reductase
MLSYVWAEDEKGAIGYQGRLPWHLPADLAHFKAKTMGHPMLMGRKTFESLPGLLPGRQHVVLSTRKLDLPAGVLQLKSEEEVSAWLKEQAGEVCVIGGSSLFALLADQVDKLEVTRIKGIFSADTYMPNLDWAAFALVKSEAHRADGKNKYDYVFETYLRKK
>NC_008054.1|WP_003619256.1|678300_679257_+|thymidylate-synthase
MANQDQAYLDLLKKIMTEGNDKNDRTGTGTRSLFGAQMRFDLSQGFPILTTKRVPFGLIKSELLWFLRGDTNIRFLLEHKNHIWDEWAFKNWVTSPEYQGPDMTDFGLRSQKDPGFKAVYDEEMQKFCQRILDDEAFAQKYGNLGDVYGAQWRHWGKRDGGFIDQIADVIEQIKTNPDSRRLIVTAWNPEDVPSSALPPCHVLFQFYVADGKLSLQLYQRSGDMFLGVPFNIASYSLLLSLIARETGLEVGEFVHTIGDAHIYKNHFAQVEEQLKRKPFDAPTLWLNPGKKKVADFEMADIKLVNYQHGSTIKAPVAV
>NC_008054.1|WP_003612584.1|676856_677234_-|hypothetical-protein
MNEDNGSRYIQPHDSLEAMELIQKLFNQYRRAPLTPELLAYHQNLIERLEGDIHQAAEAEGQAKRVQELDRMIKLMKDWTAIRLSGRPFNAKMRHFRFLPEGGQVKFKRHPHKIKASSSHRASRH
>NC_008054.1|WP_011543795.1|675147_676797_+|peptide-ABC-transporter-substrate-binding-protein
MQKIKKFTLAAVSVSAAFLLAACGSQQSSSSASKDKQVLKLSATAPLDTIDISKATGYGQTGNVFESFYRLGKNGQPAAGLAKSGTVSKDGKTWTFKLRSNAKWSNGEKITAQDFVYSWRRTINPKTASPYAYIFSGIKNADEIIAGKKSPSSLGIKALNQETVQVKLNRPIAYFKVLMAYPLFGPQNEAFIKKTGKKYATSSKYMLYSGPFKITGWKGTNDTWSFVKNNQYWDKQAVKLSKISYQVVKTTNTGYQLYQQGKLDLTPLSSEQVKQLKKNKDFKTYPYSYVAFLAYNFQAKDATVKKALNNKNIRLALSLSLDRKILTSKVFGDGSSVPTGFVASGLAYDPANKEDFAKEQKVANTVDYNEKLAEKYWKTGLKELGLKKLNLTLLASNESTNADALTQYLQSQWTKVLSGINVKVNSIPNKNAHTKALSGDFDIYVSGWGGDFSDPMTFMQILQKGTSYNYGKWNNAEYNSLIKKALTTDANDVNKRWQDLVKAAQVANADQAVSPIYQQTTAYLQNSKVKGIIHNNAGTQWSYKYAYIK
>NC_008054.1|WP_003619763.1|698065_698980_+|LysR-family-transcriptional-regulator
MLPFPYLVFQTVIDQGTFNKAAAVLNVTPSAISHSVNQLETELGFPVFVRSRNGVRLTPDGEKILPLIQEIINDQSRLEQVAQQIQGLDTGLIRIGAFSSVCINWLPPLIRNFAKNYPQVKISVRQAGFSEITQAVKSGQLDLGLTMLPENEQGISCEKILEDEIYCIAPKDFQVKNGHSISEEDLVNCNFILQQSDYDLDTKAALDHYSIKSTAISFSIDDQSIVAMVEAGLGLGILPALALQKMQGEVRILPFSTPFYRKIALVTSNQQRLAPSSRQMIKNVHELIRRQYPGGRLTMEAESA
>NC_008054.1|WP_003624246.1|699214_700912_+|arginine--tRNA-ligase
MNGKQLVAEALQAVLPDWSLDDIDVKIERPKDEKLGDYAFPTFTLAKTMRKAPNLIAAELAEKIDQGSFEKVEAVGPYINFFLDKSQTGAAILQEILADPENYGARDLGHGRNVLTEYSSPNIAKPMGMGHLRSTMIGEAIARILAKEGFKPIRIDYLGDWGTQFGKMMAAYKMWGNDADIEKDPINTLLSYYVRINREAEEHPEYDEDGREWFSKLEHGDEEAKRLWSWFREVSLERFKKVYDMLDVHFDSFTGEAFSAQMMDKPIQILREKGLLVKSQGAEIVDLEKYNLPPLMVIKSNGTSTYITRDLATAMYRKKTYGFYKSIYVVGQEQEVYFQQLRACLKEMGFDWADDIVHISFGLMSINGQKMSTRKGNVVNLEDVLNESVDLARKQISEKNVGLKNADEVAKQVGIGAVVFHDLKNYRRNPIDFNLEEVVKFEGETGPYVQYARARGESLLRKSGITDFSDADLTKIGAEEWDLVSFMARYADTIQKAMETYDPSAIAKYALELAKRFNKYYAHTRILVDDVDEDVKKARLAVVQAVSHVIKSALDLLDVKAPDEM
>NC_008054.1|WP_002879191.1|701131_701605_+|arginine-repressor
MNYKERRQLIYELIQTNKIETQEQLLLLLQAHGANATQATISRDIRALHISKVPDDDGRSYYVKAPSAAVNRERQLKDAIRERVATVTAVQFTVVIQTSMKLTYAPILAGLIDDIDNDDVVGTIAGTDTLLVILKDAEAAASFADWAQAIVKERKIY
>NC_008054.1|WP_003619769.1|701616_702816_+|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC
MARISVYMTGGIAAYKAVSVVRGLQKAGHEVRVAMTAKSERFVGPATLAALTKWPVLDDLFSPGRQAEIAHIDLADWSQLALVVPADANILAKLAQGIGDDAVSTTLLALHCPRLIVPSMNSHMWENPAVQRNLRLLKEGGDWIMEPAVGRLAEGYAGKGRMPEAEEILAWVNDQLDLPAKGKRIVVTAGGNLEAIDPVRFIGNRSSGKMGFRLAEAAAKRGAEVDLIYGNVSVPLPRDARIHLHPALSAQAMLEKLEELFPAADALLMAAAVSDWRPKEAADHKLKKQDGVEEMTLQLVKNPDLLKTMAQKKRPDQVVIGFAAETNDLLANASRKLAEKGADLIVANDVSGDAFGGDEDQVTILEQGKELDPWPWMSKQAVADRLLEMTLARLAEKKN
>NC_008054.1|WP_011543799.1|702944_703919_+|amidohydrolase
MKKIDAHLHLVRDLASYKGNGRSNALGNGLVVWDSGFKTRLFPAGWGDDAFRADAARKVMEDHDVAKAVLLQGSLYGFQNYYSWQVAKAAPDRFAPAFSIDPFASEAEKIVKRHVEDLGFRALKLEVSQAGGLMDYHLPFDLAEDDRLGKILDYLSSYPGFAVAVDYGDSSQASHQPRSLARLAKRYPDLDFVLYHLSFPKPGKLDLLEKELALFAPLPNISFDLAALQDIAGEQTYPYPFCQEAVGLAKEIVGAKRLLWGIDAPWSATFNDYGQLYSWLEDAGIFSEAELADVYYGNAERIYFKADHVAALKASRDPLFEGDA
>NC_008054.1|WP_041806442.1|703920_704871_+|2-hydroxyacid-dehydrogenase-family-protein
MENAKVLVAGLAVRQLPELEKVCEVTFAPAGAGKDWYLANLGDFDALITGKLPVDQELLDAGKKLKIVSATGVGYDHIDVDYASSQGIIVSNCPASVMQPTAEMAFTLLLALSRKLALYNQEMRQENFLDTGLLENQGQSPVGKTLGIFGMGRIGKTLASYARTFGMNILYHNRHQLPEDEERALGVSYVPLADLLSQADYVSLNAPATAETYHVIDEAALSMMQPTAFLINTSRGSQVDEAALLRALKGKRIAGAGLDVFEEEPDFNKEFCQLDNVILTPHAGSATRESRRSVLKEASHNIVSFLVDGVPVNRVN
>NC_008054.1|WP_011543801.1|704945_706715_+|DNA-helicase-RecQ
MLDPQQVLKKYFGYDSFRPGQREIIEKVFQGKNVLAVMPTGGGKSLCYQIPALMIPGATVVISPLISLMKDQVDSMREYGIPAAALNSSTAQEDVNPILRACYEGKIKLLYVTPERMEMDYFRYQLNFLEVNLVAIDEAHCISQWGHDFRPAYRKLKDGINALHTHPNVLALTATATKAVREDIGQQLDISEENFVITSFERKNLHFKLVNAPKNSRAYIVNYLKQHRGEAGIIYSNTRKKVEGLTEFLRREGFNVAAYHAGMSNEERAQVQDDFQYDRIPLIVATNAFGMGIDKSNVRFVLHANSAKNLEAYYQEAGRAGRDGLESEAVMLFHPSDLRQFRWFIDNSEADESYRQVQYQKLQTISDYANTDECLQQFIVRYFGQDCPPCGKCSNCLNSGDFQDVTAEAQAIIGMVYDLDGRYGKRIVAQAVTGSKVKKISEIGADECVHYGLLKGKKQADVSSLVDYLVSKGYLQLVGDCYPLVHVTNRGWDVLDGKARVKRRQEVKREQLAETGGDQVLFEELRKARRILAQKRGVPPFVIFSDLSLRDMAARKPQTPEELLQCSGVGDAKLANYGKAMLAVIKKYG
>NC_008054.1|WP_003619777.1|706771_707710_-|nucleoside-hydrolase
MKNFYLNHDSNMDDFTSLLLMLLVPDIKLIGVGVTDADGYVEPGVSASRKLIDRFNQRGDKLEVAKSDSRAVHQFPEAWRVSAFSVDHFPILNEKGTVETPVAAKPAHLDMIDKIHAADGPVTLVFTGPLTDLARALEIDPSIQDKIEELYWMGGSLNAHGNVYAPCADGTQEWNAWWDPEACKTVWDSKIKIQQVGLESTEELPLTDEMRQHFASNRKYPAFEFLGYVYALVNSFEVDSTYYLWDVLTTMSALYPEIATTRDTKSDVYTDGDRAARFFETENGRPMTLVTSANYDKFWERFDDLCEKAKLF
>NC_008054.1|WP_003619779.1|707983_709786_+|excinuclease-ABC-subunit-UvrC
MASQLIENKLKLLPEKAGCYLMKDVNGKVIYVGKSKNLKNRVRSYFKSSQEGRRAELVKNIADYDIIVVDSDKEAFLLEVTLIKKYQPYYNVALKSGTGYPYIEITNEKNPQTRLTSIVYKDKGYYFGPYPNVYAASATLKFIQKVFPLRRCSGYTGRPCLYYHMGQCLGSCFKEVPQSEYDEQIKKIKRFLNGDIQEVKKDLTNKMLQASADLEFERAGELRDQLKYIEETVEKQKIISNDHTQRDIFNYYVDRSWISIQVFFLRQAKLLRRESHMFPLTDETDPEDEFMSFIAQFYAQKNRVNPREVLVPKGIDQDELAAAIGIKVRTPQRGQKASLMEMARENAQLKLDDKFRLLELGQRKTKGAQEEIFKALGLPYGSYIESFDHSHIQGADPVSALVVFKDGEPFKTGYRKFKLKGEVEHQNSADEVGNTREVVRRRYSRLLKEHERMPDLILMDGGQIQVEACEDVLRNELNLDIPVAGMVKDDKHRTNHLLYGDPFKGQPFKLIPMDPKSEGFYLMTRIQDEVHRFAITFHRQTHAKNSLVSRLDSIKGIGPKSRTKLLREFGSLKKIKEASIDDLRKAGLTLTQAQAVKISL
>NC_008054.1|WP_011543802.1|709854_711177_+|GTPase-ObgE
MPTPSTFVDQTKIEVQAGKGGDGMVAFRHEKFMPNGGPAGGDGGRGGSIIFVADNGLRTLMDFRYRRKFKAEPGENGRIKAQYGKAAKDLYLKVPVGTTVYDFFTGEEIGDLVENGQELVVAKGGRGGRGNIHFATSVNTAPEIAENGEPGEFRTLRLELKVLADVGLVGFPSVGKSTLLSVVTSAKPKIAAYQFTTLKPNLGMVLLPDGRDFSMADLPGLIKGASQGVGLGIQFLRHVERTKVILHMVSMDPNNGRDAYEDYETILHELASYTEDDLSSKREIIVASQMDIPGADEKLAQFKKDLAAHGVDQEVYELSSVTHQGVDRLMSRAADLVSEVEAQEAEAAVKPKEEVKTKTYKYHRPEKMEFTVEKLADHEFEIHGEQLERLVAMTNLDHQDGIMRLARRLKRMGVDDELRAQGAVDGDDVYIGDFSFEFVQ

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Crispr_ID: NC_008054_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008054_2

764071-766562

TypeI-E

I-B,III-A,III-B

Consensus_repeat	Method
GTATTCCCCACGCAAGTGGGGGTGATCC	PILER-CR
GTATTCCCCACGCAAGTGGGGGTGATCC	CRISPRCasFinder
GTATTCCCCACGCAAGTGGGGGTGATCC	CRT

40 spacers

DEDDh,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,cas3

The CRISPR arrays of NC_008054_2

>merge|NC_008054|2|764071-766562|PILER-CR,CRISPRCasFinder,CRT
GTATTCCCCACGCAAGTGGGGGTGATCCAAAATCGTGTGCCCGTCAAGCCAGCCGGTGATTGTATTCCCCACGCAAGTGGGGGTGATCCTCACACAAAAAGCCCGCTAGATTGAATGTCTAGGTATTCCCCACGCAAGTGGGGGTGATCCTGTATTCAGTTTCGTTTGTTTGATCCTTGCCATGTATTCCCCACGCAAGTGGGGGTGATCCTCAATTTGCTGTGAGTGTAATAATTGATGGTGAGTATTCCCCACGCAAGTGGGGGTGATCCTTAAACCCAAACTATAAGCGTATGGTTCGCTCAGTATTCCCCACGCAAGTGGGGGTGATCCTGAGACTCATTGCGCCGCTACTTCAGCGGGCTAGTATTCCCCACGCAAGTGGGGGTGATCCTCTTCGATACTAATCGAAATCGATTCAAACCCTGTATTCCCCACGCAAGTGGGGGTGATCCTATGGACTAGAGGGATGCACCAGCAAGACAAGAGTATTCCCCACGCAAGTGGGGGTGATCCCCCACGCAAGTGGGGGTGATCCCATAAGCCCGGCCGGCTGCCTTTTTTGACGTGAGTATTCCCCACGCAAGTGGGGGTGATCCTAATTCGTTTTTGGGCGTGTCAGAACCTTATAAGTATTCCCCACGCAAGTGGGGGTGATCCTAGGGCTTTGAGTTACTACGGCTATGAAATGGAGTATTCCCCACGCAAGTGGGGGTGATCCGAAATGTACAAAACAGGCTTGTCTCAAGCCAAGGTATTCCCCACGCAAGTGGGGGTGATCCTAACTTAATTTGGATTGCTACCAAAAAGCCGGGGTATTCCCCACGCAAGTGGGGGTGATCCTATCAGCCTTTTCGAGGTAATCACGGTAGATTGGTATTCCCCACGCAAGTGGGGGTGATCCCCACGGGGACGACTTCGGCCAATGGACCTCCGAGTATTCCCCACGCAAGTGGGGGTGATCCCTTTACAAGTTGGCCCAAAAGTTCAGCGGGTACGTATTCCCCACGCAAGTGGGGGTGATCCCGATACTGCTGCTAATCTGTTAGCGGAGGAAAAGTATTCCCCACGCAAGTGGGGGTGATCCTCATTTTGTTAAATTTGTTTACTGAATAATTTTGTATTCCCCACGCAAGTGGGGGTGATCCTAATCAAACTTGACTAATTCATTTTCAAAAGTGGTATTCCCCACGCAAGTGGGGGTGATCCTCAGATTGTCCATATCTGCTCTCTGGCGCCTGCGTATTCCCCACGCAAGTGGGGGTGATCCTATGTTTGAACTACTTGACGGGGCGGCCTTTGCGTATTCCCCACGCAAGTGGGGGTGATCCCTGAAGTATGTTGCCGTTGCATGCACTTCAGCAGTATTCCCCACGCAAGTGGGGGTGATCCTTAAATCGAGGTGGTCAAACGTTGTACTTTAGTGTATTCCCCACGCAAGTGGGGGTGATCCTATGCACATTTGCAATCTTTATCTTAAAAGGAGGTATTCCCCACGCAAGTGGGGGTGATCCCACAGCGAGCGTTATTGCCCAAAACATAGTGTTGTATTCCCCACGCAAGTGGGGGTGATCCTACTACAGCTTAAAACAAATTTTAAAGCGAAAAGTATTCCCCACGCAAGTGGGGGTGATCCCATCCCGCAACTCCTTGACGGGGCGGCCTTGGCGTATTCCCCACGCAAGTGGGGGTGATCCTCCGTCTTTATACTCTTTATAGGCCTTTTTCGGGTATTCCCCACGCAAGTGGGGGTGATCCCTTAACCATGCAAGAAGATGAAACCGGGCTCAAGTATTCCCCACGCAAGTGGGGGTGATCCCTTTATAACTCTTGGTTTCGTGCCCACTACAAGGTATTCCCCACGCAAGTGGGGGTGATCCGAAAAAAGCCCGCTCAGGTCAAAAGCGAGCACAGTATTCCCCACGCAAGTGGGGGGTGATCCTGTTAGTGCAGGCATTTATAGAGAAGAAAAGAAGTATTCCCCACGCAAGTGGGGATGATCCTTATAAGGAATTCAACGGGAACAAATTAACTAGGTATTCCCCACGCAAGTGGGGGTGATCCTTATTGTAATTGCTGCCGGGGCTTATGCCCTCGGTATTCCCCACGCAAGTGGGGGTGATCCTGTTAGAATGGGCCAGTACGCTATCTTTTTGTGGTATTCCCCACGCAAGTGGGGGTGATCCTCATAGTTAAGGGGGATGCAGAAAATGACCAATGTATTCCCCACGCAAGTGGGGGTGATCCTATCCTTAGTCATTTTTTCCTCCTTATTTTTTTCGTATTCCCCACGCAAGTGGGGGTGATCCCTTACGGTAGATCAGACGATACTGACAGCCAGGGTATTCCCCACGCAAGTGAGGGTGATCCTGTTCTTGCCCAGAATGATAAACTCCTGCCCGAGTATTCCCCACGCAAGTGGGGGTGATCCTTTGCTGTCAGTGTAGTGATCGACGGGGAACCAGTATTCCCCACGCAAGTGGGGGTGATCC

>NC_008054|2|1|764071-766562|PILER-CR
GTATTCCCCACGCAAGTGGGGGTGATCC	AAAATCGTGTGCCCGTCAAGCCAGCCGGTGATT
GTATTCCCCACGCAAGTGGGGGTGATCC	TCACACAAAAAGCCCGCTAGATTGAATGTCTAG
GTATTCCCCACGCAAGTGGGGGTGATCC	TGTATTCAGTTTCGTTTGTTTGATCCTTGCCAT
GTATTCCCCACGCAAGTGGGGGTGATCC	TCAATTTGCTGTGAGTGTAATAATTGATGGTGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TTAAACCCAAACTATAAGCGTATGGTTCGCTCA
GTATTCCCCACGCAAGTGGGGGTGATCC	TGAGACTCATTGCGCCGCTACTTCAGCGGGCTA
GTATTCCCCACGCAAGTGGGGGTGATCC	TCTTCGATACTAATCGAAATCGATTCAAACCCT
GTATTCCCCACGCAAGTGGGGGTGATCC	TATGGACTAGAGGGATGCACCAGCAAGACAAGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CCCACGCAAGTGGGGGTGATCCCATAAGCCCGGCCGGCTGCCTTTTTTGACGTGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TAATTCGTTTTTGGGCGTGTCAGAACCTTATAA
GTATTCCCCACGCAAGTGGGGGTGATCC	TAGGGCTTTGAGTTACTACGGCTATGAAATGGA
GTATTCCCCACGCAAGTGGGGGTGATCC	GAAATGTACAAAACAGGCTTGTCTCAAGCCAAG
GTATTCCCCACGCAAGTGGGGGTGATCC	TAACTTAATTTGGATTGCTACCAAAAAGCCGGG
GTATTCCCCACGCAAGTGGGGGTGATCC	TATCAGCCTTTTCGAGGTAATCACGGTAGATTG
GTATTCCCCACGCAAGTGGGGGTGATCC	CCACGGGGACGACTTCGGCCAATGGACCTCCGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTTACAAGTTGGCCCAAAAGTTCAGCGGGTAC
GTATTCCCCACGCAAGTGGGGGTGATCC	CGATACTGCTGCTAATCTGTTAGCGGAGGAAAA
GTATTCCCCACGCAAGTGGGGGTGATCC	TCATTTTGTTAAATTTGTTTACTGAATAATTTT
GTATTCCCCACGCAAGTGGGGGTGATCC	TAATCAAACTTGACTAATTCATTTTCAAAAGTG
GTATTCCCCACGCAAGTGGGGGTGATCC	TCAGATTGTCCATATCTGCTCTCTGGCGCCTGC
GTATTCCCCACGCAAGTGGGGGTGATCC	TATGTTTGAACTACTTGACGGGGCGGCCTTTGC
GTATTCCCCACGCAAGTGGGGGTGATCC	CTGAAGTATGTTGCCGTTGCATGCACTTCAGCA
GTATTCCCCACGCAAGTGGGGGTGATCC	TTAAATCGAGGTGGTCAAACGTTGTACTTTAGT
GTATTCCCCACGCAAGTGGGGGTGATCC	TATGCACATTTGCAATCTTTATCTTAAAAGGAG
GTATTCCCCACGCAAGTGGGGGTGATCC	CACAGCGAGCGTTATTGCCCAAAACATAGTGTT
GTATTCCCCACGCAAGTGGGGGTGATCC	TACTACAGCTTAAAACAAATTTTAAAGCGAAAA
GTATTCCCCACGCAAGTGGGGGTGATCC	CATCCCGCAACTCCTTGACGGGGCGGCCTTGGC
GTATTCCCCACGCAAGTGGGGGTGATCC	TCCGTCTTTATACTCTTTATAGGCCTTTTTCGG
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTAACCATGCAAGAAGATGAAACCGGGCTCAA
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTTATAACTCTTGGTTTCGTGCCCACTACAAG
GTATTCCCCACGCAAGTGGGGGTGATCC	GAAAAAAGCCCGCTCAGGTCAAAAGCGAGCACA
GTATTCCCCACGCAAGTGGGGGGTGATC	CTGTTAGTGCAGGCATTTATAGAGAAGAAAAGAAGTATTC
CCCACGCAAGTGGGGATGATCCTTATAA	GGAATTCAACGGGAACAAATTAACTAGGTATTC
CCCACGCAAGTGGGGGTGATCCTTATTG	TAATTGCTGCCGGGGCTTATGCCCTCGGTATTC
CCCACGCAAGTGGGGGTGATCCTGTTAG	AATGGGCCAGTACGCTATCTTTTTGTGGTATTC
CCCACGCAAGTGGGGGTGATCCTCATAG	TTAAGGGGGATGCAGAAAATGACCAATGTATTC
CCCACGCAAGTGGGGGTGATCCTATCCT	TAGTCATTTTTTCCTCCTTATTTTTTTCGTATTC
CCCACGCAAGTGGGGGTGATCCCTTACG	GTAGATCAGACGATACTGACAGCCAGGGTATTC
CCCACGCAAGTGAGGGTGATCCTGTTCT	TGCCCAGAATGATAAACTCCTGCCCGAGTATTC
CCCACGCAAGTGGGGGTGATCCTTTGCT	GTCAGTGTAGTGATCGACGGGGAACCAGTATTC
CCCACGCAAGTGGGGGTGATCC

>NC_008054|2|2|764071-766562|CRISPRCasFinder
GTATTCCCCACGCAAGTGGGGGTGATCC	AAAATCGTGTGCCCGTCAAGCCAGCCGGTGATT
GTATTCCCCACGCAAGTGGGGGTGATCC	TCACACAAAAAGCCCGCTAGATTGAATGTCTAG
GTATTCCCCACGCAAGTGGGGGTGATCC	TGTATTCAGTTTCGTTTGTTTGATCCTTGCCAT
GTATTCCCCACGCAAGTGGGGGTGATCC	TCAATTTGCTGTGAGTGTAATAATTGATGGTGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TTAAACCCAAACTATAAGCGTATGGTTCGCTCA
GTATTCCCCACGCAAGTGGGGGTGATCC	TGAGACTCATTGCGCCGCTACTTCAGCGGGCTA
GTATTCCCCACGCAAGTGGGGGTGATCC	TCTTCGATACTAATCGAAATCGATTCAAACCCT
GTATTCCCCACGCAAGTGGGGGTGATCC	TATGGACTAGAGGGATGCACCAGCAAGACAAGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CCCACGCAAGTGGGGGTGATCCCATAAGCCCGGCCGGCTGCCTTTTTTGACGTGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TAATTCGTTTTTGGGCGTGTCAGAACCTTATAA
GTATTCCCCACGCAAGTGGGGGTGATCC	TAGGGCTTTGAGTTACTACGGCTATGAAATGGA
GTATTCCCCACGCAAGTGGGGGTGATCC	GAAATGTACAAAACAGGCTTGTCTCAAGCCAAG
GTATTCCCCACGCAAGTGGGGGTGATCC	TAACTTAATTTGGATTGCTACCAAAAAGCCGGG
GTATTCCCCACGCAAGTGGGGGTGATCC	TATCAGCCTTTTCGAGGTAATCACGGTAGATTG
GTATTCCCCACGCAAGTGGGGGTGATCC	CCACGGGGACGACTTCGGCCAATGGACCTCCGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTTACAAGTTGGCCCAAAAGTTCAGCGGGTAC
GTATTCCCCACGCAAGTGGGGGTGATCC	CGATACTGCTGCTAATCTGTTAGCGGAGGAAAA
GTATTCCCCACGCAAGTGGGGGTGATCC	TCATTTTGTTAAATTTGTTTACTGAATAATTTT
GTATTCCCCACGCAAGTGGGGGTGATCC	TAATCAAACTTGACTAATTCATTTTCAAAAGTG
GTATTCCCCACGCAAGTGGGGGTGATCC	TCAGATTGTCCATATCTGCTCTCTGGCGCCTGC
GTATTCCCCACGCAAGTGGGGGTGATCC	TATGTTTGAACTACTTGACGGGGCGGCCTTTGC
GTATTCCCCACGCAAGTGGGGGTGATCC	CTGAAGTATGTTGCCGTTGCATGCACTTCAGCA
GTATTCCCCACGCAAGTGGGGGTGATCC	TTAAATCGAGGTGGTCAAACGTTGTACTTTAGT
GTATTCCCCACGCAAGTGGGGGTGATCC	TATGCACATTTGCAATCTTTATCTTAAAAGGAG
GTATTCCCCACGCAAGTGGGGGTGATCC	CACAGCGAGCGTTATTGCCCAAAACATAGTGTT
GTATTCCCCACGCAAGTGGGGGTGATCC	TACTACAGCTTAAAACAAATTTTAAAGCGAAAA
GTATTCCCCACGCAAGTGGGGGTGATCC	CATCCCGCAACTCCTTGACGGGGCGGCCTTGGC
GTATTCCCCACGCAAGTGGGGGTGATCC	TCCGTCTTTATACTCTTTATAGGCCTTTTTCGG
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTAACCATGCAAGAAGATGAAACCGGGCTCAA
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTTATAACTCTTGGTTTCGTGCCCACTACAAG
GTATTCCCCACGCAAGTGGGGGTGATCC	GAAAAAAGCCCGCTCAGGTCAAAAGCGAGCACA
GTATTCCCCACGCAAGTGGGGGGTGATC	CTGTTAGTGCAGGCATTTATAGAGAAGAAAAGAA
GTATTCCCCACGCAAGTGGGGATGATCC	TTATAAGGAATTCAACGGGAACAAATTAACTAG
GTATTCCCCACGCAAGTGGGGGTGATCC	TTATTGTAATTGCTGCCGGGGCTTATGCCCTCG
GTATTCCCCACGCAAGTGGGGGTGATCC	TGTTAGAATGGGCCAGTACGCTATCTTTTTGTG
GTATTCCCCACGCAAGTGGGGGTGATCC	TCATAGTTAAGGGGGATGCAGAAAATGACCAAT
GTATTCCCCACGCAAGTGGGGGTGATCC	TATCCTTAGTCATTTTTTCCTCCTTATTTTTTTC
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTACGGTAGATCAGACGATACTGACAGCCAGG
GTATTCCCCACGCAAGTGAGGGTGATCC	TGTTCTTGCCCAGAATGATAAACTCCTGCCCGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TTTGCTGTCAGTGTAGTGATCGACGGGGAACCA
GTATTCCCCACGCAAGTGGGGGTGATCC

>NC_008054|2|1|764071-766562|CRT
GTATTCCCCACGCAAGTGGGGGTGATCC	AAAATCGTGTGCCCGTCAAGCCAGCCGGTGATT
GTATTCCCCACGCAAGTGGGGGTGATCC	TCACACAAAAAGCCCGCTAGATTGAATGTCTAG
GTATTCCCCACGCAAGTGGGGGTGATCC	TGTATTCAGTTTCGTTTGTTTGATCCTTGCCAT
GTATTCCCCACGCAAGTGGGGGTGATCC	TCAATTTGCTGTGAGTGTAATAATTGATGGTGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TTAAACCCAAACTATAAGCGTATGGTTCGCTCA
GTATTCCCCACGCAAGTGGGGGTGATCC	TGAGACTCATTGCGCCGCTACTTCAGCGGGCTA
GTATTCCCCACGCAAGTGGGGGTGATCC	TCTTCGATACTAATCGAAATCGATTCAAACCCT
GTATTCCCCACGCAAGTGGGGGTGATCC	TATGGACTAGAGGGATGCACCAGCAAGACAAGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CCCACGCAAGTGGGGGTGATCCCATAAGCCCGGCCGGCTGCCTTTTTTGACGTGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TAATTCGTTTTTGGGCGTGTCAGAACCTTATAA
GTATTCCCCACGCAAGTGGGGGTGATCC	TAGGGCTTTGAGTTACTACGGCTATGAAATGGA
GTATTCCCCACGCAAGTGGGGGTGATCC	GAAATGTACAAAACAGGCTTGTCTCAAGCCAAG
GTATTCCCCACGCAAGTGGGGGTGATCC	TAACTTAATTTGGATTGCTACCAAAAAGCCGGG
GTATTCCCCACGCAAGTGGGGGTGATCC	TATCAGCCTTTTCGAGGTAATCACGGTAGATTG
GTATTCCCCACGCAAGTGGGGGTGATCC	CCACGGGGACGACTTCGGCCAATGGACCTCCGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTTACAAGTTGGCCCAAAAGTTCAGCGGGTAC
GTATTCCCCACGCAAGTGGGGGTGATCC	CGATACTGCTGCTAATCTGTTAGCGGAGGAAAA
GTATTCCCCACGCAAGTGGGGGTGATCC	TCATTTTGTTAAATTTGTTTACTGAATAATTTT
GTATTCCCCACGCAAGTGGGGGTGATCC	TAATCAAACTTGACTAATTCATTTTCAAAAGTG
GTATTCCCCACGCAAGTGGGGGTGATCC	TCAGATTGTCCATATCTGCTCTCTGGCGCCTGC
GTATTCCCCACGCAAGTGGGGGTGATCC	TATGTTTGAACTACTTGACGGGGCGGCCTTTGC
GTATTCCCCACGCAAGTGGGGGTGATCC	CTGAAGTATGTTGCCGTTGCATGCACTTCAGCA
GTATTCCCCACGCAAGTGGGGGTGATCC	TTAAATCGAGGTGGTCAAACGTTGTACTTTAGT
GTATTCCCCACGCAAGTGGGGGTGATCC	TATGCACATTTGCAATCTTTATCTTAAAAGGAG
GTATTCCCCACGCAAGTGGGGGTGATCC	CACAGCGAGCGTTATTGCCCAAAACATAGTGTT
GTATTCCCCACGCAAGTGGGGGTGATCC	TACTACAGCTTAAAACAAATTTTAAAGCGAAAA
GTATTCCCCACGCAAGTGGGGGTGATCC	CATCCCGCAACTCCTTGACGGGGCGGCCTTGGC
GTATTCCCCACGCAAGTGGGGGTGATCC	TCCGTCTTTATACTCTTTATAGGCCTTTTTCGG
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTAACCATGCAAGAAGATGAAACCGGGCTCAA
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTTATAACTCTTGGTTTCGTGCCCACTACAAG
GTATTCCCCACGCAAGTGGGGGTGATCC	GAAAAAAGCCCGCTCAGGTCAAAAGCGAGCACA
GTATTCCCCACGCAAGTGGGGGGTGATC	CTGTTAGTGCAGGCATTTATAGAGAAGAAAAGAA
GTATTCCCCACGCAAGTGGGGATGATCC	TTATAAGGAATTCAACGGGAACAAATTAACTAG
GTATTCCCCACGCAAGTGGGGGTGATCC	TTATTGTAATTGCTGCCGGGGCTTATGCCCTCG
GTATTCCCCACGCAAGTGGGGGTGATCC	TGTTAGAATGGGCCAGTACGCTATCTTTTTGTG
GTATTCCCCACGCAAGTGGGGGTGATCC	TCATAGTTAAGGGGGATGCAGAAAATGACCAAT
GTATTCCCCACGCAAGTGGGGGTGATCC	TATCCTTAGTCATTTTTTCCTCCTTATTTTTTTC
GTATTCCCCACGCAAGTGGGGGTGATCC	CTTACGGTAGATCAGACGATACTGACAGCCAGG
GTATTCCCCACGCAAGTGAGGGTGATCC	TGTTCTTGCCCAGAATGATAAACTCCTGCCCGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TTTGCTGTCAGTGTAGTGATCGACGGGGAACCA
GTATTCCCCACGCAAGTGGGGGTGATCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008054.1\|WP_011543831.1\|773178_774537_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NC_008054.1\|WP_011543826.1\|766820_767435_+\|GTP-pyrophosphokinase	unknown	unknown	gnl\|CDD\|225232
NC_008054.1\|WP_011543821.1\|757455_759180_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|187860
NC_008054.1\|WP_011543833.1\|775181_776126_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|234786
NC_008054.1\|WP_041806458.1\|770620_771847_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	unknown	unknown	gnl\|CDD\|153082
NC_008054.1\|WP_011543823.1\|759824_760901_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_008054.1\|WP_011543822.1\|759198_759807_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	mkCas0194_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NC_008054.1\|WP_011543818.1\|752942_753146_+\|hypothetical-protein	unknown	unknown	unknown
NC_008054.1\|WP_011543834.1\|776266_778528_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NC_008054.1\|WP_003619879.1\|762221_763172_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_008054.1\|WP_003619878.1\|761595_762219_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl\|CDD\|378050
NC_008054.1\|WP_011543820.1\|754687_757453_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|182031
NC_008054.1\|WP_011543824.1\|760881_761583_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|187886
NC_008054.1\|WP_011543828.1\|768102_769362_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_008054.1\|WP_011543832.1\|774594_775101_-\|aminoacyl-tRNA-deacylase	unknown	unknown	gnl\|CDD\|237976
NC_008054.1\|WP_041806455.1\|751401_752706_+\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NC_008054.1\|WP_003619893.1\|771850_773014_+\|hydroxymethylglutaryl-CoA-synthase	unknown	unknown	gnl\|CDD\|213655
NC_008054.1\|WP_011543827.1\|767431_768100_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_008054.1\|WP_011543825.1\|763168_764041_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
NC_008054.1\|WP_011543829.1\|769517_770618_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383

Protein	Function_ID	Function_description	E-value
NC_008054.1\|WP_011543831.1\|773178_774537_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	5.84401e-63
NC_008054.1\|WP_011543826.1\|766820_767435_+\|GTP-pyrophosphokinase	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	1.12268e-62
NC_008054.1\|WP_011543821.1\|757455_759180_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	4.68466e-96
NC_008054.1\|WP_011543833.1\|775181_776126_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|234786	PRK00517, prmA, 50S ribosomal protein L11 methyltransferase.	1.73194e-91
NC_008054.1\|WP_041806458.1\|770620_771847_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	gnl\|CDD\|153082	cd00644, HMG-CoA_reductase_classII, Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR), class II, prokaryotic enzyme is a homodimer. Class II enzymes are found primarily in prokaryotes and Archaeoglobus fulgidus and are soluble as they lack the membrane region. Enzymes catalyze the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. Bacteria, such as Pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. Human and bacterial HMGR differ in their active site architecture.	0
NC_008054.1\|WP_011543823.1\|759824_760901_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	6.98022e-156
NC_008054.1\|WP_011543822.1\|759198_759807_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	1.86747e-30
NC_008054.1\|WP_011543829.1\|769517_770618_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	2.28694e-160
NC_008054.1\|WP_011543834.1\|776266_778528_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NC_008054.1\|WP_003619879.1\|762221_763172_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	5.67957e-143
NC_008054.1\|WP_003619878.1\|761595_762219_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	3.4353e-70
NC_008054.1\|WP_011543820.1\|754687_757453_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	3.25493e-81
NC_008054.1\|WP_011543824.1\|760881_761583_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|187886	cd09756, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	1.60235e-53
NC_008054.1\|WP_011543828.1\|768102_769362_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.10777e-28
NC_008054.1\|WP_011543832.1\|774594_775101_-\|aminoacyl-tRNA-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	4.502e-65
NC_008054.1\|WP_041806455.1\|751401_752706_+\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NC_008054.1\|WP_011543827.1\|767431_768100_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.52982e-66
NC_008054.1\|WP_011543825.1\|763168_764041_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	2.79671e-45
NC_008054.1\|WP_003619893.1\|771850_773014_+\|hydroxymethylglutaryl-CoA-synthase	gnl\|CDD\|213655	TIGR01835, 3-hydroxy-3-methylglutaryl_CoA_synthase, 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade. This clade of hydroxymethylglutaryl-CoA (HMG-CoA) synthases is found in a limited spectrum of mostly gram-positive bacteria which make isopentenyl pyrophosphate (IPP) via the mevalonate pathway. This pathway is found primarily in eukaryotes and archaea, but the bacterial homologs are distinct, having aparrently diverged after being laterally transferred from an early eukaryote. HMG-CoA synthase is the first step in the pathway and joins acetyl-CoA with acetoacetyl-CoA with the release of one molecule of CoA. The Borellia sequence may have resulted from a separate lateral transfer event.	9.16099e-131

>NC_008054.1|WP_011543825.1|763168_764041_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MIVITLTKTPPALRGDLTRWCQEIQTGVYVGDVSARVRDKLWERVQTNIGNGEATLVYNTNNEQGYAFKTTRKSKQVVDLDGMLFVKHVVNQETVEHGFSNAAKFHKAHKAEKMRASAAAAKPKGFVAVDIETTGLNTETDQILSIGAVKHDGTEFYRLIKQDIDVPKQIVELTGITSEMLSKEGVPLQDALEELTDFVGNVPIVGYNFRFDSAFLNRDYRKCGMQELKNEIKDLLPVVKRKEKFLDNYKLQTVLSNYGIENKVPHNAVSDARATKELAMKLIKNRILVI
>NC_008054.1|WP_003619879.1|762221_763172_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MKVEASYKKPDLTELGRTEDRITFLYIEHAKLYRKDGAVEVRDEEGIVYVPAAIISVLLLGPGVDVTHRAMELMGDSGMAVVWVGEQGVRQYAHGRALNRSSRLLEAQAKLVSNVRSRVAVARKMYQLRFPDEDVTKLTMEEMRGKEGTRVRRVYREQAKKTGVKWSKREYKVDDFESETPINKALTAAHQALYGLSYSVIVALGASPGLGFIHTGHDLAFVYDFADLYKADISIPIAFETVAKYGDDDIASRIRHAMRDKFRETKLIKQMVVDLKHLLLGDADQDQDIDVMNLWDDKLGLQKFGVQYHEQQSDEE
>NC_008054.1|WP_003619878.1|761595_762219_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSRVEIDTDNRQKIKDLSHLGAYHNWVERSFPAEIAEGERQRHLWRLDTLNGRNYLLLLSPEKPDLHEFERYGKPGTAISKDYEPFLSRLSEGQLLQFKLTANPVRRGGKSSSHPGSLIPCFAVDEQMKWLQGKAEKNGFELVAAEVVGHDRPLLRKKTHVALNRTVFEGRLKISNLDQFKAMLTSGIGREKAFGMGLMTVIPVD
>NC_008054.1|WP_011543824.1|760881_761583_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MKTLTIKLTAPLQAYGNEASFERRTSWPAPSKSAVVGMIAAALGMRREDERIKSLNDLAYAVRVDQIGKTMTEFQTVEWKPGTRKLTYRDHYQDAVYVAAVGSEDEELIGKIEYALKHPRFQLYLGRRACPPAGVLRIESFADTDPVKVLENMPWQAEKWYQNKQKRKAEFTAEIIADANLLPDAAFTQTVKDRVESLDPQGRCFGFRLTAKERINLKNPCYEQKSQDIMDYL
>NC_008054.1|WP_011543823.1|759824_760901_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MTKNLYVDINVLQTVPSSNINRDDTGAPKTAFYGGVTRARVSSQSWKRAVRKAFAEDGANIGTRTKRVPQMLAAKLQDLDASLDEDAAMSKAIDALKEGGIKTNKDNETGALLMVSPGQVAKLASYVLENETLDKKEVKKILMEGNSLDLALFGRMVADNPELNVDASAQVAHAISTHEIIPEYDYFTALDDLQEKEKSGAALIQTTQYDSATLYRYANINMAELSYNLGDEDAIEGALTFVKDFALSMPTGKQNSFANKTLPNYLMVTVRDDTPVNLVSAFESPVVAKAGEGYVENSVKKLENEYKDALQFVDQPLATVTVGKYETTVGEQAGNLQDLLGKLQDVLKKAVENEDFNN
>NC_008054.1|WP_011543822.1|759198_759807_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MAFEIEKATERIIRQLYNNGDTDKASLSALRSAATIDGYRAQKVWPVFLSNLDEQWLSKNGKATREEAAIFAAVRMYALHQQASDSCVFGRRNYSDKKDEETNSRELFEALNCLKQGTDSHEALDRRVQALLGTNNYNAVIDQLVHLMQIIKSKKTGIKIDYARLAGDLYKFQFGYRQANEVRLRWGEQYYRAFKKLDTNQQ
>NC_008054.1|WP_011543821.1|757455_759180_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MESYNLITEPWIKVLDGKTNSEHMVSIKELLQNASDYRQLAGEMHAQDLAVLRLLEAILTTVYTRVDQNDEEYEWVTLDEQMHVQSYDDEIEGSTLLQVLTKTWNALYKEGSFSEAVFDYLDKNKGLFDFFGDRPFYQVTAEQYDSFVPDNKKIAKGSGTVDLMQINRLISQSGNSVAIFSPKSANRKNKLTLDELVRWVITYQNFTGVTDKTKVKAKKKMSNSRGWLYTLNPVYAQGKNLFETLMLNLLLFNPNKPAYTQQRPVWEEDLGEYVKRRLSQVKPDNFAETYTVWSRLLHIEWQDGTPTIFSAGLPTFDSANAYDIEPMSTWRMNKKDENYYPATRQLSSIGIAMWRNFGQYVDIEGHTESREPLTVAWLNYLKTKNEFLNQQMINLHTSGIISNGGATSLMPAAEFDDNLRIEADVLFDETEDRKNAWPQRIEEMVDLNQEVGRKYYGFLMEVGRIRFGPQGAADFAGRNSQTFYDNLNEPFENWLANLSGGDDRDKQQELWKKQLRQIALRTLDDFLEIIAPRDISGIKADKSQSGTKSTESNIFIAANKYRAGINKALNKNEK
>NC_008054.1|WP_011543820.1|754687_757453_+|CRISPR-associated-helicase/endonuclease-Cas3
MKLSKEALSLWGKKSNQDGDEHWLPLVAHMVDTMNVGHWLYNSWLSEGQRSMLTTRICDAEMSKLVSFLCYIHDLGKATPAFQTKESYNHDHQLDEELIHRLVSHSFKKLNDLSLPSRSKSPHARAGEAILERAGLNETIAAIVGGHHGKPQNGDQEEQIDVFTSNYYQADNDEEIQQPWKDAQRELIDYGLELAGYEDISEVPPVNQPEAVILEGLLIMADWLASSTCLNNDPDKPMFNLIGLDQSFDDLDMKARYQNAISTWAINDAWIPEEVANVDYYYEQHFSFKPRQIQAAMEEHVKEAVDPGLVIIEAEMGIGKTEIALTAAEQLAYVTGRTGVYIGLPTQATTNAMFDRVNSWLTKIAGIEGINPDIKLLHGKAEWNSRYTDLPRAEDIEAEELDAGTVTVNSWFSGKKSILADFAVGTIDNLLLMGLKQKHLFLRHLGFSNKVVIIDEVHAYDMYMQSYLSKALKWLGAYHVPVVILSATLPKEKRNELIKSYIKGKYRRVKKVLQAQEGWESNRAYPLLSLLDGKELRQYSDFGPKAEPREMQVNYINDEPTEVLAKVNDKIKDGGIAGIIVNTVKRAQEFAGLVGQDCQCLVLHSAFLATDRSRLEKELQSLIGKKGKRPDKLIVIGTQVLEQSLDIDFDVMFTDIAPIDLLLQRAGRLHRHKISRPKGLEKRQLYVMKPDSDDYGPANEAVYEKYYLQKTEHFLPQKIQLPNDISRLVQLVYDEDTDDQVENLDEARDKLNVDRNREKSKAESFQINDPVYPAAKNDLYDDTWVEELTIHRWLDRDKGNLDDNQASAAVRDIRESIEVILLKEISGEYYLMNGDKVSEMMDKDLAKELIRLPNAVTPNIEQAINILEENTAQAFPDWQGSPWLKGSLAVVLDEHAKGSFNGYKLRYSTETGLSYEKEVDN
>NC_008054.1|WP_011543818.1|752942_753146_+|hypothetical-protein
MGESKEDKRMRAKWESLSGAEKSEFKKNYAMRRGITIDFIRRWAWNEGDLDNLEYHIAERRKKFREF
>NC_008054.1|WP_041806455.1|751401_752706_+|argininosuccinate-lyase
MYPEDIAGSIAHAKMLAKQGIIPEEASAKIIAGLEGILADLNSGKLEIDPAAEDIHMFIEETLTDRIGQDGKMLHTARSRNDQVALDIRLYMREENGQIKQLLKDLVAALCDQAEKYKASLMPGYTHLQRAQPVTFGHQLMAYAYMFMRDLERLGQMEERMNYSPIGSCALAGTTYPIDRVYEAELLGFKAPVANSLYGVSDRDHVVEDLSDLALVMMHLSRLSEELILWSSWEFHFVRLADAYTTGSSIMPQKKNPDMAELARGKTGRVYGDLMAILTTLKGLPLAYNKDMQEDKEALFDAIDNVELCLETFIPMIKTLEANEKAMHQAAQKGFINATDLADYLTKKGMPFRDAYHISGQLVALCIDQDTVLEDLPLETYKGYSDLFEEDLYQAIDLHNCLAKRTSLGGPTPESVQKQVDEVRGKLKIRINRC
>NC_008054.1|WP_011543826.1|766820_767435_+|GTP-pyrophosphokinase
MSIYGKYADYLPQILDSVLQQIQGIGQEYSAEHGQKLYGHLEGRVKGEESMAQKCERKGLPLMPESALIENRDAIGLRIVCNFIDDIYTCIDLLKKQDNFKIINEKDYITDAKPNGYRSYHLIMEVVTPFEDVHGNKPGIYYVEIQLRTIAMDTWASLEHEMKYKHDIKNPERISKELKRVADELASCDVSMQTIRQLIKEGEL
>NC_008054.1|WP_011543827.1|767431_768100_+|response-regulator-transcription-factor
MKILLAEDEAQLNRVLTVAMQKSGYDVDSVFNGQEAVDAVKKHPYDVIIMDIMMPVKNGLDAVKEIRSTGDKTYIMMLTAKSEIDDKVTGLDVGADDYLTKPFSLKELLVRLRSKERRSEDYNSTQELNYDNLKLDLNSQELSSNNSISLSKQETGLMRYFLLNPGKAISTEELFNHVWKNEDESEDVVWVYISFLRSKLASIGANVQISGEKGGEFCLERA
>NC_008054.1|WP_011543828.1|768102_769362_+|HAMP-domain-containing-histidine-kinase
MIKKIRRRFIWLATLSLFLVILFSFSSLIGISLFESSHEADQVLSIIVKNNGRLDEVQAKKRLGDQYNKEGMFKYRYFTANINTKKQTLTVIDADHIIGYSINSVSSRKKQISRRLSAGQLKGTIHSNGVRFRYLAKKISANKYYICFIDLSPLMQSALLLVRYALIFTFGGILFFVIIMTLLADKAIQPIKDAYYKQRRFITNAGHELKTPLAVISANAEMEELLGNDDEWSESTKEQVVRMTGLINQLITLTRMSEPGELVLSKVNFSEITKESADSFKSVLAKDNKKYVVSIDPDLYINAEQRSLLELVNILIDNAQKYCDPEGEVMVVLAKSRLNQNAVLTVTNSYKNGAGIDTNRFFERFYREDESHHYDQKQKNGFGIGLSMAQDLVAAFGGKINASWSDGVMNFTVTFKRVH
>NC_008054.1|WP_011543829.1|769517_770618_+|thiolase-family-protein
MQDIYIVAAKRTPFGRYHKQLADFSAIDLGQIALRGALKEAGLDAEALDALFMGNVLSAGLGQNMARQIALNAGMRQDSVAVSINEVCGSSLKAARLAEAQMLIGDLGLVAVGGSESMTNASKEIMFSDGLVDSFSGKSMGITAENVAKRNHISRQDADAFSLSSHQKAVKAQAEGLFADEIIQIEDLKQDENVRPDTSLEALAGLKTSFLEDGTVTAGNASPISDGASMIILATAEKVAEYQLTPLAKLGAYAEVGYDPEFMGYGPYYAIRKLLNETGRQVADYDFFEINEAFAATTLAVARDLEIPLAKVNKQGGAIALGHPLGASGTRLLATAARQLQRGGQRAIASLCIGGGLAIAFEIEKA
>NC_008054.1|WP_041806458.1|770620_771847_+|hydroxymethylglutaryl-CoA-reductase,-degradative
MKFYQLPPEERRQFLQEDGVALEDIPAADLARLDEMSENVVGEVKFPLSCLTSALVNGKNWRIPMTTEEASVVAAANHGMSVFAKAGGVKATSQRDGIYGQIVLEVTEAFSLAGFKKEFPAYIKEANKEFTSLIRHGGGLKDLTARQEADLVYLLALVDPAEAMGANKTNAILEFLAQKMLAFPGVEAKLFAILSNYPSQLTTAKVAIPVSLLSKKGDLAEGREVAKKMALLAKIGSSDPYRAVTNNKGIMNGVDAVMLATGNDYRAVEAACHAYAAKSGEYRSLSSWKIAGEKLLGQVTLPLALGVVGGSISSRPDIRQSYAILGKIKAAELAELTASVALANNFAALSAISTKGIQAGHMRLQSRNVVQTLPASAEEKAAVYQMMISQGKYGETAAKNFLKELRGQ
>NC_008054.1|WP_003619893.1|771850_773014_+|hydroxymethylglutaryl-CoA-synthase
MDIGIDQIGFYTPNKFVDMVDLANARNQDPNKFLIGIGQDRMAVADKTQDAVSMGINATAEYLDQVDLEQLGLLIFATESGIDQSKSASLFVKEALNLPARIRTFEIKEACFALTASLQVARDYVRAHPHHSAMIIGSDIARYGLATAGEVTQGAGAISMLIKENPAIIALEDGHTSHSENINDFWRPNNLATAVVDGHYSRDVYLDFFKSTFKPFLAEKQLQVSDFAGICYHLPYTKMGYKAHKIAIEGQDDETVKRLSDNFQLSAKYSRQVGNIYTASLYMSVLSLLENGDLEAGDRIGFFSYGSGAMAEFFSGKVVAGYQKRLRPALHARMLKERIRLGVGQYEDIFTEGLEALPENVEFTSDANHGTWYLAGQEGYVRQYKQK
>NC_008054.1|WP_011543831.1|773178_774537_+|threonine/serine-exporter-family-protein
MKTESTEQEYQHHLSHHHHMRVQWEEFFQSDDETKIKEATLIEKGSIISRVGMMILSCGTGAWRVRDAMDTLARTLDLTCSTDIGLISIVCTYFDVDNQSYSQSLALPTTGVNMAKLNELEKFVRQFEAAGGDFEIKTVRRRLGEIEHMKGRYPLWGSSLAAALACGGFIFLLGGGLPEIICSFIGAGLGQFARGSLAKRRITVAATTAVGVAAACLSYYLAFMLGHLLFNVDMIHMRGYIGAMLFVIPGFPFITSGLDIAKLDMRSGLERMAYAILIILIATGTGCVMATALQIKPGDLPALHLSKAILTACRLLASFCGVFGFSLMFNSHRRMAAAAGLVGAIANTMRLSLVDFAHFPAPLAAFLAALLAGLLAGYVREKVGYPRIALTVPSIVIMVPGLYMYRGIFFLALTNVGAGATWMTEALMLVMSLPAGLLTARILNDKKWRRVD
>NC_008054.1|WP_011543832.1|774594_775101_-|aminoacyl-tRNA-deacylase
MSKKKKNKDKLDKTLVEKILDQHKIAYEQHISEISEDHGVAQVGTGKPVLDGHPVYKTLAVNGNKTGPIVGVVPLSGHLDLKKIAKVSGNKKCEMIPLKQLEKTTGYVHGANTPIGIYHSKKFPIFLDESVLKEDGIWVSSGEVGRSVMVNPLDLQELVKATVADLQE
>NC_008054.1|WP_011543833.1|775181_776126_+|50S-ribosomal-protein-L11-methyltransferase
MKLLEIKIESSYDVEDALAYFATEDLKALGTEARRRSDFEQAGWLHDSTVVDMDDIPNLPDELEFIAYFDEETDPEEMVKCFKDKLAELAGYGLKTAPGEISVDYVADQDWNTVWKKYYHVINLSRHLAIVPEWEDYQPAFKDQEIIRLDPGLAFGTGNHQTTQLAMLGIERAMVKPLTVADVGTGSGILAIAAHKLGAKSVLATDISDESMTAAEENAALNGIHDIALQKTSLLADVDGKFDLIVANILAEILLDLIPQLDSHLNEDGQVIFSGIDYLQLPKIEQALAENSFQIDLKMRAGRWIGLAISRKHD
>NC_008054.1|WP_011543834.1|776266_778528_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MSKYTEMTHEQVMAACKKYITADQLAFVESAYQFAARAHEGQTRASGQPYIVHPTQVAGILANLGLDPDTVAAGFLHDTVEDTSVTNDDIKEKFGADVAFIVDGVTKLNKYEYKSHKEFLAENHRKMLIAMAKDLRVILVKLADRLHNMHTLEHLRPDKQRRIAAETLDIYAPLADRLGIGTIKWKLEDMSFHYMNPEAYYKIVSMMDAKRSEREGYIKDAIDYLRGTLDSLGIKYDISGRPKHIYSIYKKMVNKHKNFNEIYDLLAVRVIVPTVKDCYAVLGAVHTKWKPMPGRFKDYIAMPKANGYQSLHTTIIGPGGKPLEIQIRTEEMHKVAEYGVAAHWAYKRGNFQGVDEKEGGALDIGREILELQKDSSDADEFMEAVHSDIFADKVYVFTPKGEVYELPKGSVTLDFAYAIHTQVGDHAIGAKVNDKLVPLDYKLKNGDVVDILTQSNARPSRDWAEMVKTSRAKNKIRRYFRDVDREESLARGKSELVDLLKENGLSAKDFLDKSHIDEVLDHFSFKTDEDMYAAIGFGNMSAVSIYNRLTADLRRQQEEEKQKQFEAQIMSAGQQAAASSVVKKPAPQKDDAKSKTKGKKPDSLVRVQGLEDLDMHFAKCCNPVPGDLIVGYVTKGRGVTVHRVDCRNVVSADPAAQGRMIDVEWNNIDEGKQASFNANFELFGYNRQKLLGDVINRLNALTKNITNVSASVNEENIAHFYITVEVRNAAQLNDIMAKLRDIPDVYDTKRTDN

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Crispr_ID: NC_008054_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008054_3

1761303-1761405

Orphan

Consensus_repeat	Method
GTTGGCGTAGGGGAGTGAGAACGATGAAGATCGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008054_3

>merge|NC_008054|3|1761303-1761405|CRISPRCasFinder
GTTGGCGTAGGGGAGTGAGAACGATGAAGATCGATGTTATTCGATACCTCGACGACAGTGGTATAATAGTTGGCGTAGGGAAGTGAGAACGATGAAGATCGAT

>NC_008054|3|3|1761303-1761405|CRISPRCasFinder
GTTGGCGTAGGGGAGTGAGAACGATGAAGATCGAT	GTTATTCGATACCTCGACGACAGTGGTATAATA
GTTGGCGTAGGGAAGTGAGAACGATGAAGATCGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008054.1\|WP_003620441.1\|1748557_1749961_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NC_008054.1\|WP_011544317.1\|1750405_1750645_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|236766
NC_008054.1\|WP_011544329.1\|1774818_1775742_-\|dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235982
NC_008054.1\|WP_157862420.1\|1764672_1765038_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_008054.1\|WP_003623962.1\|1771738_1773016_-\|dihydroorotase	unknown	unknown	gnl\|CDD\|236479
NC_008054.1\|WP_003616492.1\|1777086_1777284_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_008054.1\|WP_011544327.1\|1761753_1763844_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NC_008054.1\|WP_080571483.1\|1764082_1764772_+\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_008054.1\|WP_011544324.1\|1758192_1758951_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NC_008054.1\|WP_011544320.1\|1751402_1752311_+\|hypothetical-protein	unknown	unknown	unknown
NC_008054.1\|WP_011544323.1\|1754105_1755686_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_008054.1\|WP_011544328.1\|1773015_1773972_-\|aspartate-carbamoyltransferase-catalytic-subunit	unknown	unknown	gnl\|CDD\|234849
NC_008054.1\|WP_003620452.1\|1752711_1753212_-\|O-acetyl-ADP-ribose-deacetylase	unknown	unknown	gnl\|CDD\|394878
NC_008054.1\|WP_003623965.1\|1770653_1771739_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
NC_008054.1\|WP_003621085.1\|1774116_1774659_-\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	unknown	unknown	gnl\|CDD\|235365
NC_008054.1\|WP_011544321.1\|1752375_1752615_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371212
NC_008054.1\|WP_011544325.1\|1760531_1761200_+\|cobyric-acid-synthase	unknown	unknown	gnl\|CDD\|225974
NC_008054.1\|WP_003620455.1\|1753211_1753994_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NC_008054.1\|WP_003624639.1\|1755672_1757868_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|223589
NC_008054.1\|WP_080571485.1\|1765323_1766223_-\|transposase	unknown	unknown	gnl\|CDD\|379252

Protein	Function_ID	Function_description	E-value
NC_008054.1\|WP_003620441.1\|1748557_1749961_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NC_008054.1\|WP_011544317.1\|1750405_1750645_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|236766	PRK10811, rne, ribonuclease E; Reviewed.	0.00182211
NC_008054.1\|WP_157862420.1\|1764672_1765038_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.81542e-06
NC_008054.1\|WP_003623962.1\|1771738_1773016_-\|dihydroorotase	gnl\|CDD\|236479	PRK09357, pyrC, dihydroorotase; Validated.	0
NC_008054.1\|WP_003616492.1\|1777086_1777284_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	8.85016e-33
NC_008054.1\|WP_011544327.1\|1761753_1763844_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NC_008054.1\|WP_011544329.1\|1774818_1775742_-\|dihydroorotate-dehydrogenase	gnl\|CDD\|235982	PRK07259, PRK07259, dihydroorotate dehydrogenase.	5.41927e-166
NC_008054.1\|WP_011544324.1\|1758192_1758951_-\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	3.88732e-63
NC_008054.1\|WP_011544325.1\|1760531_1761200_+\|cobyric-acid-synthase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	3.17679e-73
NC_008054.1\|WP_011544323.1\|1754105_1755686_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.50651e-65
NC_008054.1\|WP_011544328.1\|1773015_1773972_-\|aspartate-carbamoyltransferase-catalytic-subunit	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	5.19628e-157
NC_008054.1\|WP_003620452.1\|1752711_1753212_-\|O-acetyl-ADP-ribose-deacetylase	gnl\|CDD\|394878	cd02908, Macro_OAADPr_deacetylase, macrodomain, O-acetyl-ADP-ribose (OAADPr) family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family includes eukaryotic macrodomain proteins such as human MacroD1 and MacroD2, and bacterial proteins such as Escherichia coli YmdB; these have been shown to be O-acetyl-ADP-ribose (OAADPr) deacetylases that efficiently catalyze the hydrolysis of OAADPr to produce ADP-ribose and free acetate. OAADPr is a sirtuin reaction product generated from the NAD+-dependent protein deacetylation reactions and has been implicated as a signaling molecule. By acting on mono-ADP-ribosylated substrates, OAADPr deacteylases may reverse cellular ADP-ribosylation.	3.16627e-94
NC_008054.1\|WP_003623965.1\|1770653_1771739_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NC_008054.1\|WP_003620455.1\|1753211_1753994_-\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	1.57569e-73
NC_008054.1\|WP_011544321.1\|1752375_1752615_-\|hypothetical-protein	gnl\|CDD\|371212	pfam10726, DUF2518, Protein of function (DUF2518). This family is conserved in Cyanobacteria. Several members are annotated as the protein Ycf51. The function is not known.	0.00608723
NC_008054.1\|WP_080571483.1\|1764082_1764772_+\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	7.33469e-19
NC_008054.1\|WP_003624639.1\|1755672_1757868_-\|serine/threonine-protein-kinase	gnl\|CDD\|223589	COG0515, SPS1, Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair].	1.05424e-08
NC_008054.1\|WP_003621085.1\|1774116_1774659_-\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	gnl\|CDD\|235365	PRK05205, PRK05205, bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR.	2.43573e-98
NC_008054.1\|WP_080571485.1\|1765323_1766223_-\|transposase	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.97381e-09

>NC_008054.1|WP_011544325.1|1760531_1761200_+|cobyric-acid-synthase
MDDNLIRIAYLYEDLMNTYGDSGDVKILRYFLQKKGWQTQIDNISLGSQFNAADYDFVFFGGGQDYEQSIVAKDLQRFKETLNDYIQAGNPMLAICGGYELMGTHYNTISGTKIKGLGILPLHTEFDPDKRMIGDTKYETEWGPTIGFENHSGQTFLDDRKMLKPLAKVVEGYGNNHEEKEDGVRYKNFIGSWSHGPMLKNENVANALVDIILKRHAARVAQ
>NC_008054.1|WP_011544324.1|1758192_1758951_-|tyrosine-protein-phosphatase
MPKRIVKLEAGYNCRDLGGYVSQDGRTVKWGRLYRSGSLSHLTKADQSELVRRKIVVDCDLRSRHEQDNFPDKLWPGAKLVDAHFYSESGDEEEEAEAAWEKYSGKLPKLSYLAMVYQQNLVAPRTGLVMRKIFKEMLALEDDEALIYHCSMGKDRTGMVSVNVLMALGLEDREILRDYLLSREYSWDWDEADENDRLGQQIAKMNQTQVSQTAFYGITETIRQTWGGFDRYFASLGFGQGDLDRLRDKFLE
>NC_008054.1|WP_003624639.1|1755672_1757868_-|serine/threonine-protein-kinase
MKYKLINGDFCVRQYNHVDVVPTNFLGLSREIISRDPHHVFLQINKSAASLPRQGFKIHVSATLQNYQVILDKVYDLSCENNFTFKYISNYSLLEQYLGGTGPLWMTGKYITIYPETESRFEKLIRTIYDLVGKEDGIPIFTDQAFRDSKNVYYRYGIINSDDDFIRDERNNKLYRDHELRTYQLPSFVKEPFESKNEHKLETIGKKYLLKGIISRKSSGGVYRAQDIYGRDVVIKRAKYRFKDSEETEIQKLQNERKNLINWEKYDFIPKVLDSFYEQKDFFLVESYIKGVLIDDLRAEFIGDKRNSFYFAKIRHIVLNYLRCLQRLHNDSFFLGDISASNIIVDFESEKVFLVDVSQSALLTNMDESFYYRTKGFYDRRVDNLSPELQDVHQSGYLVMSVFSRANDFLKIDQSGKQSWNFFIKQAAQEKIPAVFIKVMKVLINATAGSLDRAIEILQKDDMNVLSQITTTQQLPLKSLLQGLQRPVAIEQIEENSLDEKNSEDEVVKALLSVELGNNNCPVPAFEQSQLKIFEELSRTRPSMEKILRQLFLIVEYLRERVPTASVKFDNFDITIKKIESMFWVENNDFCGYRLFAKSKYISPYLKNGMAGMLIVLMNAKVIYQTKAYDRRIKQLANELSKMAYAKNGTFIEGLSGITWILIKYVEQSHDRDYMPLIERQLSFYQYFCVDCHGLMYLIDSRSEALDTSLFYGNRGMAFVLKEWEKLNENR
>NC_008054.1|WP_011544323.1|1754105_1755686_-|ABC-transporter-ATP-binding-protein
MKIGELVKQNRLRFTCAVALEVLVQLCVAVGNYIIGFILDLLVKRETSRFYLVLAVFFVLYIGGYVLISFAEYLYIVQVQEYVHQLRRKTVDYYYQNHETVAEMQSHLTNDFQMLFDNFTQPLFVFFDSALAVVFSAYALVTMHWILLVTTVLLSVMFLYLPSIFSKKYQERTLIFSNMNTAYLTSIKNWLGGLAEIQRYDARHKLVEVLEKRSKKLEGSLVTRQVSAIEINFINGFMSIFCQVVLDVVTGTLILAGTISIGKLVAVGQFSSTIFNSLVMLSNYLEQIKSTKPLNEKVAAALADPPKDVCTDEELTSFDHLQTTGLSFSYDHGETINYPDLKIKVGEKILLTGDSGTGKSTLLKVLAGELKATTGNIAFYDHDDRKIDISLKAMHYVPQDPVLFPVSIAENITMFKPKLDDKVGEYLQKVDLAKDIAKFPKGQDTVIDVEELNVSGGQRQKIVLARAELNQSDFILIDEATAAVDQDSTKRILKNLLKTNATIIFIGHNFTNEMVDMFDRQIVLSK
>NC_008054.1|WP_003620455.1|1753211_1753994_-|tyrosine-protein-phosphatase
MEMQRVIELDMPVNFRDLGGYQGLDGRQVKWRKIYRSAALNEMSARDRVKLANLRITVDCDLRSSREQRSYPDLLWPGVRFVNIGLYAEGDRFNQAHPFLRLFHHLPEFDDYLPKIYQQVLLNEHSEEGIKRVFEELLKLPEDQALVYHCAAGKDRTGIISILILMALGVDDKTIAEDYLLTDELYDFSIEKQHPTNEKLSQVIAKMNVTRGEGTAVKGITETIRQGWGSFDKFFTRKLGFKQADLEKFREMYLEEEEED
>NC_008054.1|WP_003620452.1|1752711_1753212_-|O-acetyl-ADP-ribose-deacetylase
MNLEIWQGDITTLKVDAIVNAANRELRGGGGVDGAIHRAAGPKLNEACRALGSCETGEAKITPGFNLPAKYIIHTVGPVYSGSHSDPLLLAACYRNSLRVAKENGLHSVAFSAISTGVYGYPLDAASKVAFGEVRKWLREHKDYEMRVIMVAYDARTYALYQKLLG
>NC_008054.1|WP_011544321.1|1752375_1752615_-|hypothetical-protein
MLRKYYVTIVFTLLALLNLLSSWGTLQYRLVMLALNLVCGFSMEYLVNKKAPAEKYNLWKGCMAAVLLAVNLLWIFLTK
>NC_008054.1|WP_011544320.1|1751402_1752311_+|hypothetical-protein
MARMSRRQYQERQEQTAQKQTRQRNPNSVPRLDTDGASRSEQKVRLNFWQIFADRPYVTVIMISLALFCILAKWWIGLAIIIILTIAGIFVIGRSHHPNRVLSLEFKLKASRKLSMIKALQLLGSTIMFLAAYMRQIVSVDFSSAGATDSLTVIQNMLSNQGTFGQQGSYFLSLFNQLTGGSLWGTYRYATNSSQMMNSTAGTMIILWIFLLMIAPAFCVLSQFFREPYSRHVMTVASLISTISFTLTPTLMNRWVISYAVQNQMSQAAAENAVQVGGMVYPAIISAVFVFILAIYREIKKD
>NC_008054.1|WP_011544317.1|1750405_1750645_-|LPXTG-cell-wall-anchor-domain-containing-protein
MTVVNTDEEPATKSAAKTPTLVTKLANTAPVAKAPAATAAQLPQTGEKDAKPGILAGILSLLAGVSLFGFSFEKRKQEK
>NC_008054.1|WP_003620441.1|1748557_1749961_-|class-II-fumarate-hydratase
MAEQEYRIESDTIGEVKIPKEALWGPQTERSRNNFQSGELMPLAIIRAFLHLKKAAAESNVEVGDEPAEKGQAIEEAIDQLLALSDEDLRKDFPLHVLQTGSGTQTNMNVNEVVANLANKLHPGLNILPNDDVNRGQSSNDTYPTAMNIVAVEAVDKLEPAIEHLIDELKVKQDKYWKTVKVGRTHLQDATPLTFGQEVSGYISALKHDLAYIQELKPSLYELAIGGTAVGTGLNAAPGMTEAIAGKLSEVYGHEFKVDTNKFWGLAHHSALSVMHGAFKTLANDMFKIAQDIRFLASGPRAGYGELNIPANEPGSSIMPGKVNPTQAEAVTMAVARVLGNDVTINFAASQGNFEMNVFKTVMIAAFLESADILAGTITGFADKMIHGLTVNEQRMDDLLENSLMTVTALSPKIGYHEAAVIAQTAQREGTTLKEAALKSGKVTEEQYDEWMDYMAMTNIDRTKPEE
>NC_008054.1|WP_011544327.1|1761753_1763844_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MDYNNFNDMDDLFRELMNGLGGFNSENRRYLINGRQVTPEEFAEYQKTGQLPGHGQAKNFQGKQKKANGILEKLGRNLTAEAREGKLDPVIGRNKEIQETAEILSRRIKNNPVLVGDAGVGKTAVVEGLAQAIVHGDVPEAIKNKEIISIDISSLEAGTQYRGSFEQNIQDLVKEVKDRGNVILFFDEIHQILGAGGMGDGNGSKGMSDILKPALSRGEITVIGATTQDEYRNTIMKDAALARRFNEVTVNAPSQADTFKILMGIRSLYEKHHNVELPDDVLKAAIDYSVQYIPQRSLPDKAIDLLDMTAAHLAAQHPVTDAKTIEKQIKEEKQAQKKAAEKEDYQAALDHKAKAEKLEKQLSENHEERKTVATPADVAAAVERLTGIPVSKMGASDIERLKGLSSRLKGKIIGQDEAVEAVAKAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDAIIRLDMSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTEKVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTIIIATSNAGFGNEQLMGDAKKDEKLMDRLAPYFRPEFLNRFNAVIEFSHLTKEDLKEIVNLMLADVNKTLAKKGISLTVSESAKDYLIEQGYDEAMGARPLRRVIEQEIRDKVTDYYLDHLDVKKLKADMVDGALVISEDK
>NC_008054.1|WP_080571483.1|1764082_1764772_+|sensor-domain-containing-diguanylate-cyclase
MQPENLWDAITHQIKLGVFWKDRQRNFLGANQYFLDYYGLTLPEVIGLNVHPENFQESEMQLLEDGVPVKERGKTRSRGQIREIMILKAPVYDQDQIVGLIGFFMDITNTSKQINRLENEAARDDLTSLKNRHNFARDFNYLTGKPILAMMLDVDHFKKFNDNFGHRYGDEVLKKISQALLKIYGIGHCYRYGGTNSWCSATLLILTRLRKKTGSSGKNWNMPGSWIFT
>NC_008054.1|WP_157862420.1|1764672_1765038_+|diguanylate-cyclase
MVLRDFTDTDTVAEKDRQFRKELEHARVLDLYMNITVSAGYAYGIANNSDEIKSMIRLADHNLYQVKKNGRKDICGSLFQPNFLNMSKKKQRESLICFHAVFFVAGNGRQRQGQPWQKQYC
>NC_008054.1|WP_080571485.1|1765323_1766223_-|transposase
MSSLPSFDTKNEPQISRSVEKFFKYYKVMELLRRCGLRKSKGIPLWSVLSYIFSNVFRDRSMYMQQKSGKCTAGFSKNTYYRFMQNPHINWLRLTILLADRIVNGHLKDLTSDQRADCFVFDDSLYSKTGYKKTELTAKVFDHVSMTYKKGFRMMTMGWTDGSSFVPIASSLLSSKNDQNVIGTTKKIDKRTIAAKRRIMAQSKGTDVLDQALKAGLTAKYVMFDTWFSNRLVPSVLPASPSSTLSWLPWAPAACTTSNCLKTAGLLLPKSPTTTWALSGKPSWRPWLPSPTCPRPSAW
>NC_008054.1|WP_003623965.1|1770653_1771739_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MRYLILEDGSIYAGEGFGSDRETTGEVVFTTGMTGYQEAITDQSYADQILVFTNPLIGNYGITLADYESLQPQIKGVICHQIARHPDNWRMQTTLPEFLKQLHIPGIQGIDTRELVKKLRVHGTLRGKIANSKENAEKIVQELKHKNVTQGVISRVSTKSAYPVPGSKRNIVVIDFGIKHSILRELAERDCNCIVLPYTATAEEVLNLHPDGVLLSNGPGDPEEMIEATKMVQEVEKHVPLFGICMGHQVFALANGAKTYKMKFGHRGFNHPVREIATGHIGFTSQNHGYAVDAKSIDKDNLMITHEEVNDGTVEGLRHKKYPAFSVQFHPDATPGPHDEDSLFDDFMSMIDQRKEEERHA
>NC_008054.1|WP_003623962.1|1771738_1773016_-|dihydroorotase
MQTVIKNGTVYQNGRLIHADVLIEDQKIKAIGTDLTGDKVIDATGKLVSPGLVDVHVHYRDPGQTYKEDIETGSKAAAHGGFTTVGAMPNVTPVPDTPDLMKKMVQENKQKGIVHIFQYGPITKNETTDELPDYAALKKAGAFALSNDGHGVQTAQTMYLAMQEAKKNDLIVAAHAQDDSLFNHGIVNEGEKAKELNLPPVTELAETTQIARDLLLAEKTGVHYHICHVSTKTSVELVRMAKACGINVTCEAAPHHLLLTEDDIPKDNGYYKMNPPLRSKEDQAALLVGLLDGTIDLIATDHAPHAKQEKQGGMQNAAFGITGSETAFSTLYTKFVKEDKVFTLEQLLSWLSDQPAKVFGLKKAGVLEPGCPADVAIFDLEHETELKEKNYQSKGINTPFTGQKIYGATVMTMVDGEVVYQRGEK
>NC_008054.1|WP_011544328.1|1773015_1773972_-|aspartate-carbamoyltransferase-catalytic-subunit
MKNLNLVALPHFVSVENLKNDEVKALIKRAEYFKKGGAVARLTSPVYVTNMFFEDSSRTHTSFEMAERKLGLTVIPFDPAHSSVNKGETLYDTSLVMNALGIDLEVIRHSQNEYYEDLINLKQHQKLNIGVINAGDGSGQHPSQCMLDMMTIHEHFGHFKGLKVAIVGDITNSRVAKSDMELLTKLGAEVYFSGPECWYSEEFDQYGKHEELDKLIPKMDVMMLLRVQHERHSGDPNEKKFDAHRYHEKYGINHKRYEAMKKDAIIMHPGPINHNVELSGDLVESDKCMFVRQMENGVFMRMAMLEAVLRGRKLGGLE
>NC_008054.1|WP_003621085.1|1774116_1774659_-|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR
MAKEIWDALAIKRALTRITYEIIEQNKGTDDLVLVGIKTRGVHLANRIHDRIQKLEGVDVPVGELDITLYRDDRHDALLKQDPVVNSDNVGVDINNKRVVLIDDVIYTGRTIRAAMDALMHVGRPSLIKVAVLVDRGHRELPIRADFVGKNIPTSADEQVAVNVVEKDGKDSVELKALPK
>NC_008054.1|WP_011544329.1|1774818_1775742_-|dihydroorotate-dehydrogenase
MVNTHVNLPGLDLKNPVMPASGTFGFGDVPAAQKFDLNDLGAMVIKTTTPHATTGNPQPQIAILEDGVLNSVGLTNPGVDQVISEKLTKLRHQYLDLPIMASVGGDSEDDYVEVAKKLSASGLVNALEINVSCPNVAQGGMSFGVHAGVVEELTKKIKMAVALPIYVKLTPNVTDIVEIAKAAESGGADGISMINTVLGMRIDVKTRKPLLGHNMGGLSGEAVKPIAIRMISQVRQVTQLPIIGMGGISTAQDVIEFILAGANAVAVGSAHFEDELAAKHIAENLPAELEKLGIEDINDLVGQVKFN
>NC_008054.1|WP_003616492.1|1777086_1777284_+|cold-shock-protein
MQNGTVKWFNADKGFGFITGSDGDVFVHFSSIKTNGFKSLEEGQKVSYDVEQGNRGPQATNVVPQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_008054_2	2.1\|764099\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	764099-764131	33	NC_008054.1	105896-105928	0	1.0

1. spacer 2.1|764099|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to position: 105896-105928, mismatch: 0, identity: 1.0

aaaatcgtgtgcccgtcaagccagccggtgatt	CRISPR spacer
aaaatcgtgtgcccgtcaagccagccggtgatt	Protospacer
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MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_008054_2	2.10\|764670\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	764670-764702	33	NC_010909	Lactobacillus delbrueckii subsp. bulgaricus plasmid pDOJ1, complete sequence	62-94	2	0.939
NC_008054_2	2.10\|764670\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	764670-764702	33	NC_014728	Lactobacillus delbrueckii subsp. bulgaricus ND02 plasmid unnamed, complete sequence	62-94	2	0.939
NC_008054_2	2.19\|765219\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	765219-765251	33	NZ_CP021331	Maritalea myrionectae strain HL2708#5 plasmid pHL2708X3, complete sequence	136871-136903	6	0.818
NC_008054_2	2.34\|766141\|33\|NC_008054\|PILER-CR	766141-766173	33	NZ_CP040823	Paraoceanicella profunda strain D4M1 plasmid pD4M1E, complete sequence	51772-51804	6	0.818
NC_008054_2	2.43\|766135\|33\|NC_008054\|CRISPRCasFinder,CRT	766135-766167	33	NZ_CP040823	Paraoceanicella profunda strain D4M1 plasmid pD4M1E, complete sequence	51772-51804	6	0.818
NC_008054_2	2.8\|764526\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	764526-764558	33	NC_001670	Lactobacillus delbrueckii plasmid pWS58, complete sequence	6959-6991	7	0.788
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	MH622943	Myoviridae sp. isolate ctbc_4, complete genome	201868-201901	7	0.794
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	MH622943	Myoviridae sp. isolate ctbc_4, complete genome	201868-201901	7	0.794
NC_008054_2	2.10\|764670\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	764670-764702	33	NC_002191	Lactobacillus delbrueckii subsp. bulgaricus plasmid pLBB1, complete plasmid sequence	64-96	8	0.758
NC_008054_2	2.18\|765158\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	765158-765190	33	MK250029	Prevotella phage Lak-C1, complete genome	383828-383860	8	0.758
NC_008054_2	2.18\|765158\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	765158-765190	33	MK250016	Prevotella phage Lak-A1, complete genome	418610-418642	8	0.758
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP008811	Campylobacter fetus subsp. venerealis 97/608 plasmid pCFV97608-1, complete sequence	13274-13307	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	MK448675	Streptococcus phage Javan129, complete genome	40161-40194	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	MK448850	Streptococcus phage Javan132, complete genome	39261-39294	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	MN855961	Bacteriophage sp. isolate 145, complete genome	3136-3169	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP039706	Clostridium butyricum strain 4-1 plasmid p-butyl_plas_4-1, complete sequence	666799-666832	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP033246	Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence	433667-433700	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP033248	Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence	433708-433741	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_AP019717	Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence	705131-705164	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP039703	Clostridium butyricum strain 29-1 plasmid p-butyl_plas_29-1, complete sequence	25777-25810	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP013238	Clostridium butyricum strain CDC_51208 plasmid pNPD4_2, complete sequence	147006-147039	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP019921	Borreliella burgdorferi strain PAbe plasmid p_cp32-9-4, complete sequence	49597-49630	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NC_018984	Borrelia burgdorferi 297 plasmid 297_cp32-4, complete sequence	19513-19546	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP019848	Borreliella burgdorferi plasmid cp32-4, complete sequence	18939-18972	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP019759	Borreliella burgdorferi strain B31_NRZ isolate B31 plasmid p_cp32-4, complete sequence	18940-18973	8	0.765
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP017204	Borreliella burgdorferi strain B331 plasmid B331_cp32_10, complete sequence	19298-19331	8	0.765
NC_008054_2	2.41\|766012\|34\|NC_008054\|CRISPRCasFinder,CRT	766012-766045	34	NC_001949	Lactococcus lactis DPC3147 plasmid pMRC01, complete sequence	34029-34062	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP008811	Campylobacter fetus subsp. venerealis 97/608 plasmid pCFV97608-1, complete sequence	13274-13307	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	MK448675	Streptococcus phage Javan129, complete genome	40161-40194	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	MK448850	Streptococcus phage Javan132, complete genome	39261-39294	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	MN855961	Bacteriophage sp. isolate 145, complete genome	3136-3169	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP039706	Clostridium butyricum strain 4-1 plasmid p-butyl_plas_4-1, complete sequence	666799-666832	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP033246	Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence	433667-433700	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP033248	Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence	433708-433741	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_AP019717	Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence	705131-705164	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP039703	Clostridium butyricum strain 29-1 plasmid p-butyl_plas_29-1, complete sequence	25777-25810	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP013238	Clostridium butyricum strain CDC_51208 plasmid pNPD4_2, complete sequence	147006-147039	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP019921	Borreliella burgdorferi strain PAbe plasmid p_cp32-9-4, complete sequence	49597-49630	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NC_018984	Borrelia burgdorferi 297 plasmid 297_cp32-4, complete sequence	19513-19546	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP019848	Borreliella burgdorferi plasmid cp32-4, complete sequence	18939-18972	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP019759	Borreliella burgdorferi strain B31_NRZ isolate B31 plasmid p_cp32-4, complete sequence	18940-18973	8	0.765
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP017204	Borreliella burgdorferi strain B331 plasmid B331_cp32_10, complete sequence	19298-19331	8	0.765
NC_008054_2	2.18\|765158\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	765158-765190	33	NC_017296	Clostridium acetobutylicum EA 2018 plasmid pEA2018, complete sequence	168578-168610	9	0.727
NC_008054_2	2.18\|765158\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	765158-765190	33	NC_015686	Clostridium acetobutylicum DSM 1731 plasmid pSMBa, complete sequence	168578-168610	9	0.727
NC_008054_2	2.18\|765158\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	765158-765190	33	NC_001988	Clostridium acetobutylicum ATCC 824 plasmid pSOL1, complete sequence	168578-168610	9	0.727
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_CP032532	Bacillus megaterium NCT-2 plasmid pNCT2_4, complete sequence	91378-91411	9	0.735
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	MK448768	Streptococcus phage Javan47, complete genome	37820-37853	9	0.735
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_CP032532	Bacillus megaterium NCT-2 plasmid pNCT2_4, complete sequence	91378-91411	9	0.735
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	MK448768	Streptococcus phage Javan47, complete genome	37820-37853	9	0.735
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	MN693046	Marine virus AFVG_25M413, complete genome	25308-25341	10	0.706
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	MN693008	Marine virus AFVG_117M9, complete genome	25286-25319	10	0.706
NC_008054_2	2.41\|766012\|34\|NC_008054\|CRISPRCasFinder,CRT	766012-766045	34	NC_047810	Escherichia phage vB_EcoS-IME253, complete genome	30040-30073	10	0.706
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	MN693046	Marine virus AFVG_25M413, complete genome	25308-25341	10	0.706
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	MN693008	Marine virus AFVG_117M9, complete genome	25286-25319	10	0.706
NC_008054_2	2.7\|764465\|33\|NC_008054\|PILER-CR,CRISPRCasFinder,CRT	764465-764497	33	NC_023136	Leisingera methylohalidivorans DSM 14336 plasmid unnamed, complete sequence	133502-133534	11	0.667
NC_008054_2	2.37\|766324\|34\|NC_008054\|PILER-CR	766324-766357	34	NZ_LR214986	Mycoplasma cynos strain NCTC10142 plasmid 13	580929-580962	11	0.676
NC_008054_2	2.46\|766318\|34\|NC_008054\|CRISPRCasFinder,CRT	766318-766351	34	NZ_LR214986	Mycoplasma cynos strain NCTC10142 plasmid 13	580929-580962	11	0.676

1. spacer 2.10|764670|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to NC_010909 (Lactobacillus delbrueckii subsp. bulgaricus plasmid pDOJ1, complete sequence) position: , mismatch: 2, identity: 0.939

taattcgtttttgggcgtgtcagaaccttataa	CRISPR spacer
taattcgtttttgggcgtgtcagaacctgttaa	Protospacer
****************************  ***

2. spacer 2.10|764670|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to NC_014728 (Lactobacillus delbrueckii subsp. bulgaricus ND02 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.939

taattcgtttttgggcgtgtcagaaccttataa	CRISPR spacer
taattcgtttttgggcgtgtcagaacctgttaa	Protospacer
****************************  ***

3. spacer 2.19|765219|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021331 (Maritalea myrionectae strain HL2708#5 plasmid pHL2708X3, complete sequence) position: , mismatch: 6, identity: 0.818

taatcaaacttgactaattcattttcaaaagtg---	CRISPR spacer
taatcaaacttgactaattgaattt---aagtatgt	Protospacer
******************* * ***   ****.

4. spacer 2.34|766141|33|NC_008054|PILER-CR matches to NZ_CP040823 (Paraoceanicella profunda strain D4M1 plasmid pD4M1E, complete sequence) position: , mismatch: 6, identity: 0.818

ttattgtaattgctgccggggcttatgccctcg	CRISPR spacer
cgctggtgagtgctgccggggcttatgccctcg	Protospacer
.  * **.* ***********************

5. spacer 2.43|766135|33|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP040823 (Paraoceanicella profunda strain D4M1 plasmid pD4M1E, complete sequence) position: , mismatch: 6, identity: 0.818

ttattgtaattgctgccggggcttatgccctcg	CRISPR spacer
cgctggtgagtgctgccggggcttatgccctcg	Protospacer
.  * **.* ***********************

6. spacer 2.8|764526|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to NC_001670 (Lactobacillus delbrueckii plasmid pWS58, complete sequence) position: , mismatch: 7, identity: 0.788

tatggactagagggatgcaccagcaagacaaga	CRISPR spacer
tatggattagagggatgcaccagcatgagggac	Protospacer
******.****************** ** ...

7. spacer 2.37|766324|34|NC_008054|PILER-CR matches to MH622943 (Myoviridae sp. isolate ctbc_4, complete genome) position: , mismatch: 7, identity: 0.794

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
gcttatctt---tcatttattcctccttatatttttt	Protospacer
   ****.*   ****** *********** *****.

8. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to MH622943 (Myoviridae sp. isolate ctbc_4, complete genome) position: , mismatch: 7, identity: 0.794

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
gcttatctt---tcatttattcctccttatatttttt	Protospacer
   ****.*   ****** *********** *****.

9. spacer 2.10|764670|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to NC_002191 (Lactobacillus delbrueckii subsp. bulgaricus plasmid pLBB1, complete plasmid sequence) position: , mismatch: 8, identity: 0.758

taattcgtttttgggcgtgtcagaaccttataa	CRISPR spacer
taattcgtttttgggcgtgtcataatccggact	Protospacer
********************** **.*. .

10. spacer 2.18|765158|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to MK250029 (Prevotella phage Lak-C1, complete genome) position: , mismatch: 8, identity: 0.758

tcattttgttaaatttgtttactgaataatttt	CRISPR spacer
tatattgattaaatttagttactgaataatttc	Protospacer
*   ** .********. **************.

11. spacer 2.18|765158|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to MK250016 (Prevotella phage Lak-A1, complete genome) position: , mismatch: 8, identity: 0.758

tcattttgttaaatttgtttactgaataatttt	CRISPR spacer
tatattgattaaatttagttactgaataatttc	Protospacer
*   ** .********. **************.

12. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP008811 (Campylobacter fetus subsp. venerealis 97/608 plasmid pCFV97608-1, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
catagatattcattttttactccttattttttga	Protospacer
.**   ** ********* *************

13. spacer 2.37|766324|34|NC_008054|PILER-CR matches to MK448675 (Streptococcus phage Javan129, complete genome) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
ttgcggttgtcattgtttcctccttattttttat	Protospacer
*  *  * ****** ***************** .

14. spacer 2.37|766324|34|NC_008054|PILER-CR matches to MK448850 (Streptococcus phage Javan132, complete genome) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
ttgcggttgtcattgtttcctccttattttttat	Protospacer
*  *  * ****** ***************** .

15. spacer 2.37|766324|34|NC_008054|PILER-CR matches to MN855961 (Bacteriophage sp. isolate 145, complete genome) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
tatccttagtcattttttactcctcttattacat	Protospacer
****************** *****. * ** . .

16. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP039706 (Clostridium butyricum strain 4-1 plasmid p-butyl_plas_4-1, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

17. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP033246 (Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

18. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP033248 (Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

19. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_AP019717 (Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

20. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP039703 (Clostridium butyricum strain 29-1 plasmid p-butyl_plas_29-1, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

21. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP013238 (Clostridium butyricum strain CDC_51208 plasmid pNPD4_2, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

22. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP019921 (Borreliella burgdorferi strain PAbe plasmid p_cp32-9-4, complete sequence) position: , mismatch: 8, identity: 0.765

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
aaaaatctt---tcattttttactccttattttgtta	Protospacer
    ***.*   ********* *********** **

23. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NC_018984 (Borrelia burgdorferi 297 plasmid 297_cp32-4, complete sequence) position: , mismatch: 8, identity: 0.765

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
aaaaatctt---tcattttttactccttattttgtta	Protospacer
    ***.*   ********* *********** **

24. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP019848 (Borreliella burgdorferi plasmid cp32-4, complete sequence) position: , mismatch: 8, identity: 0.765

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
aaaaatctt---tcattttttactccttattttgtta	Protospacer
    ***.*   ********* *********** **

25. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP019759 (Borreliella burgdorferi strain B31_NRZ isolate B31 plasmid p_cp32-4, complete sequence) position: , mismatch: 8, identity: 0.765

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
aaaaatctt---tcattttttactccttattttgtta	Protospacer
    ***.*   ********* *********** **

26. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP017204 (Borreliella burgdorferi strain B331 plasmid B331_cp32_10, complete sequence) position: , mismatch: 8, identity: 0.765

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
aaaaatctt---tcattttttactccttattttgtta	Protospacer
    ***.*   ********* *********** **

27. spacer 2.41|766012|34|NC_008054|CRISPRCasFinder,CRT matches to NC_001949 (Lactococcus lactis DPC3147 plasmid pMRC01, complete sequence) position: , mismatch: 8, identity: 0.765

--ctgttagtgcaggcatttatagagaagaaaagaa	CRISPR spacer
tatggttg--gcaagaatttatagagaagaaaagca	Protospacer
  . ***.  ***.* ****************** *

28. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP008811 (Campylobacter fetus subsp. venerealis 97/608 plasmid pCFV97608-1, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
catagatattcattttttactccttattttttga	Protospacer
.**   ** ********* *************

29. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to MK448675 (Streptococcus phage Javan129, complete genome) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
ttgcggttgtcattgtttcctccttattttttat	Protospacer
*  *  * ****** ***************** .

30. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to MK448850 (Streptococcus phage Javan132, complete genome) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
ttgcggttgtcattgtttcctccttattttttat	Protospacer
*  *  * ****** ***************** .

31. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to MN855961 (Bacteriophage sp. isolate 145, complete genome) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
tatccttagtcattttttactcctcttattacat	Protospacer
****************** *****. * ** . .

32. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP039706 (Clostridium butyricum strain 4-1 plasmid p-butyl_plas_4-1, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

33. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP033246 (Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

34. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP033248 (Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

35. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_AP019717 (Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

36. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP039703 (Clostridium butyricum strain 29-1 plasmid p-butyl_plas_29-1, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

37. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP013238 (Clostridium butyricum strain CDC_51208 plasmid pNPD4_2, complete sequence) position: , mismatch: 8, identity: 0.765

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
taatatctgtcatttttttctccttatctttttt	Protospacer
** . *. **********.********.*****.

38. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP019921 (Borreliella burgdorferi strain PAbe plasmid p_cp32-9-4, complete sequence) position: , mismatch: 8, identity: 0.765

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
aaaaatctt---tcattttttactccttattttgtta	Protospacer
    ***.*   ********* *********** **

39. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NC_018984 (Borrelia burgdorferi 297 plasmid 297_cp32-4, complete sequence) position: , mismatch: 8, identity: 0.765

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
aaaaatctt---tcattttttactccttattttgtta	Protospacer
    ***.*   ********* *********** **

40. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP019848 (Borreliella burgdorferi plasmid cp32-4, complete sequence) position: , mismatch: 8, identity: 0.765

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
aaaaatctt---tcattttttactccttattttgtta	Protospacer
    ***.*   ********* *********** **

41. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP019759 (Borreliella burgdorferi strain B31_NRZ isolate B31 plasmid p_cp32-4, complete sequence) position: , mismatch: 8, identity: 0.765

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
aaaaatctt---tcattttttactccttattttgtta	Protospacer
    ***.*   ********* *********** **

42. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP017204 (Borreliella burgdorferi strain B331 plasmid B331_cp32_10, complete sequence) position: , mismatch: 8, identity: 0.765

---tatccttagtcattttttcctccttatttttttc	CRISPR spacer
aaaaatctt---tcattttttactccttattttgtta	Protospacer
    ***.*   ********* *********** **

43. spacer 2.18|765158|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to NC_017296 (Clostridium acetobutylicum EA 2018 plasmid pEA2018, complete sequence) position: , mismatch: 9, identity: 0.727

tcattttgttaaatttgtttactgaataatttt	CRISPR spacer
acaaacgtataaatttgtttattgaataatctt	Protospacer
 **  .   ************.********.**

44. spacer 2.18|765158|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to NC_015686 (Clostridium acetobutylicum DSM 1731 plasmid pSMBa, complete sequence) position: , mismatch: 9, identity: 0.727

tcattttgttaaatttgtttactgaataatttt	CRISPR spacer
acaaacgtataaatttgtttattgaataatctt	Protospacer
 **  .   ************.********.**

45. spacer 2.18|765158|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to NC_001988 (Clostridium acetobutylicum ATCC 824 plasmid pSOL1, complete sequence) position: , mismatch: 9, identity: 0.727

tcattttgttaaatttgtttactgaataatttt	CRISPR spacer
acaaacgtataaatttgtttattgaataatctt	Protospacer
 **  .   ************.********.**

46. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_CP032532 (Bacillus megaterium NCT-2 plasmid pNCT2_4, complete sequence) position: , mismatch: 9, identity: 0.735

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
cctttataggcattttttcttccttatttttagc	Protospacer
. *.. *** *********.***********  *

47. spacer 2.37|766324|34|NC_008054|PILER-CR matches to MK448768 (Streptococcus phage Javan47, complete genome) position: , mismatch: 9, identity: 0.735

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
ttgcggttgtcatcgtttcctccttattttttat	Protospacer
*  *  * *****. ***************** .

48. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_CP032532 (Bacillus megaterium NCT-2 plasmid pNCT2_4, complete sequence) position: , mismatch: 9, identity: 0.735

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
cctttataggcattttttcttccttatttttagc	Protospacer
. *.. *** *********.***********  *

49. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to MK448768 (Streptococcus phage Javan47, complete genome) position: , mismatch: 9, identity: 0.735

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
ttgcggttgtcatcgtttcctccttattttttat	Protospacer
*  *  * *****. ***************** .

50. spacer 2.37|766324|34|NC_008054|PILER-CR matches to MN693046 (Marine virus AFVG_25M413, complete genome) position: , mismatch: 10, identity: 0.706

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
tttttgctttcattttctactccttatttttttg	Protospacer
* *.. .  *******.* **************

51. spacer 2.37|766324|34|NC_008054|PILER-CR matches to MN693008 (Marine virus AFVG_117M9, complete genome) position: , mismatch: 10, identity: 0.706

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
tttttgctttcattttctactccttatttttttg	Protospacer
* *.. .  *******.* **************

52. spacer 2.41|766012|34|NC_008054|CRISPRCasFinder,CRT matches to NC_047810 (Escherichia phage vB_EcoS-IME253, complete genome) position: , mismatch: 10, identity: 0.706

ctgttagtgcaggcatttatagagaagaaaagaa	CRISPR spacer
tatttagtgcaggcagttatagtgaagatatttc	Protospacer
.  ************ ****** ***** *

53. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to MN693046 (Marine virus AFVG_25M413, complete genome) position: , mismatch: 10, identity: 0.706

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
tttttgctttcattttctactccttatttttttg	Protospacer
* *.. .  *******.* **************

54. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to MN693008 (Marine virus AFVG_117M9, complete genome) position: , mismatch: 10, identity: 0.706

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
tttttgctttcattttctactccttatttttttg	Protospacer
* *.. .  *******.* **************

55. spacer 2.7|764465|33|NC_008054|PILER-CR,CRISPRCasFinder,CRT matches to NC_023136 (Leisingera methylohalidivorans DSM 14336 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.667

tcttcgatactaatcgaaatcgattcaaaccct	CRISPR spacer
agatcgatactcatcgaaatcggttcatttgtg	Protospacer
   ******** **********.****  . .

56. spacer 2.37|766324|34|NC_008054|PILER-CR matches to NZ_LR214986 (Mycoplasma cynos strain NCTC10142 plasmid 13) position: , mismatch: 11, identity: 0.676

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
atttgcgtttcattttttactccttattttatta	Protospacer
  *. .   ********* *********** **

57. spacer 2.46|766318|34|NC_008054|CRISPRCasFinder,CRT matches to NZ_LR214986 (Mycoplasma cynos strain NCTC10142 plasmid 13) position: , mismatch: 11, identity: 0.676

tatccttagtcattttttcctccttatttttttc	CRISPR spacer
atttgcgtttcattttttactccttattttatta	Protospacer
  *. .   ********* *********** **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

238847 : 255399

Planktothrix_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003619471.1\|238847_239891_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.7e-19	32.2
WP_011543591.1\|239905_240859_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.5e-21	33.3
WP_080554281.1\|240940_241078_+	DUF975 family protein	NA	NA	NA	NA
WP_003622302.1\|241210_242524_-	C1 family peptidase	R4TV59	Phaeocystis_globosa_virus	3.3e-62	32.7
WP_011543592.1\|242575_243889_-	C1 family peptidase	R4TV59	Phaeocystis_globosa_virus	3.3e-62	33.3
WP_003619462.1\|243985_244411_-	Hsp20/alpha crystallin family protein	NA	NA	NA	NA
WP_011543593.1\|244638_245100_+	transcription elongation factor GreA	NA	NA	NA	NA
WP_003622306.1\|245183_246473_-	adenylosuccinate synthase	L7Y4J5	Megavirus	1.6e-72	38.2
WP_003622309.1\|246658_247651_+	GMP reductase	Q4ZCY7	Staphylococcus_virus	1.8e-132	68.4
WP_011543594.1\|247779_249087_+	Y-family DNA polymerase	M1Q231	Streptococcus_phage	1.0e-87	40.8
WP_041806400.1\|249079_249439_+	hypothetical protein	E3W8I0	Leuconostoc_phage	6.0e-06	34.8
WP_011543596.1\|249508_250801_-	purine permease	Q9KX94	Enterobacteria_phage	8.2e-29	31.0
WP_003619447.1\|250830_251400_-	xanthine phosphoribosyltransferase	NA	NA	NA	NA
WP_003619444.1\|251754_252912_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	4.1e-56	31.3
WP_003619442.1\|252911_254465_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	3.5e-18	30.2
WP_003616790.1\|254789_255041_+	type II toxin-antitoxin system HicA family toxin	NA	NA	NA	NA
WP_003616793.1\|255027_255399_+	type II toxin-antitoxin system HicB family antitoxin	A0A0K2CZV4	Paenibacillus_phage	8.9e-21	45.6

DBSCAN-SWA_2

972693 : 982134

Bacillus_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011543913.1\|972693_973644_-	2-hydroxyacid dehydrogenase	A0A1J0F959	Only_Syngen_Nebraska_virus	7.6e-32	34.2
WP_041806509.1\|973855_974293_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_011543914.1\|974292_976020_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.3e-33	26.6
WP_011543915.1\|976019_977777_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.1e-41	24.7
WP_003618103.1\|977859_978168_-	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_041806511.1\|978216_978612_-	ribonuclease HI	M4QMN0	Micromonas_pusilla_virus	1.4e-08	31.5
WP_157862418.1\|978608_978935_-	viroplasmin family protein	F2Y108	Organic_Lake_phycodnavirus	7.1e-06	33.7
WP_050899095.1\|979765_980209_-	ribonuclease HI	A0A0H3UZB5	Geobacillus_virus	3.7e-13	32.8
WP_011543917.1\|980457_980940_-	hypothetical protein	NA	NA	NA	NA
WP_011543918.1\|981146_981413_-	N-acetyltransferase	NA	NA	NA	NA
WP_011543919.1\|981414_982134_-	HAD family hydrolase	M1H9H9	Acanthocystis_turfacea_Chlorella_virus	1.2e-05	24.1

DBSCAN-SWA_3

993912 : 1086591

Streptococcus_phage(13.64%)

integrase,tRNA,transposase,protease

attL 1023119:1023163|attR 1050995:1051039

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011543931.1\|993912_994665_+\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_011543932.1\|995831_997262_-	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_003620545.1\|997362_998883_-	ABC transporter permease/substrate-binding protein	NA	NA	NA	NA
WP_011543933.1\|998886_999810_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.1e-26	38.7
WP_003623037.1\|1000140_1000602_+	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_041806782.1\|1001055_1001475_+	3-beta hydroxysteroid dehydrogenase	NA	NA	NA	NA
WP_011543934.1\|1001536_1002448_-	M48 family metallopeptidase	NA	NA	NA	NA
WP_011543935.1\|1002599_1003025_-	hypothetical protein	NA	NA	NA	NA
WP_011543936.1\|1003168_1004341_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_011543938.1\|1004610_1010451_-	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	7.8e-10	30.3
WP_011543941.1\|1012112_1012727_+	DedA family protein	NA	NA	NA	NA
WP_011543942.1\|1013077_1014094_+	aspartate--ammonia ligase	A0A1C9C5F0	Heterosigma_akashiwo_virus	2.7e-59	38.8
WP_011543871.1\|1014169_1015468_+\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	8.2e-53	28.4
WP_041806525.1\|1015520_1016825_-\|transposase	ISL3-like element ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	1.4e-57	33.0
WP_003619632.1\|1018108_1021135_-	DUF4981 domain-containing protein	L0N6M2	Herpes_simplex_virus	1.3e-141	32.9
WP_011543943.1\|1021138_1023022_-	PTS sugar transporter subunit IIA	NA	NA	NA	NA
1023119:1023163	attL	NA	NA	NA	NA
WP_011543944.1\|1023637_1024861_+\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	1.3e-97	49.0
WP_003618241.1\|1027128_1027440_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_011543945.1\|1027619_1028456_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_003618238.1\|1028498_1029065_+	signal peptidase I	NA	NA	NA	NA
WP_011543946.1\|1029134_1029320_+	hypothetical protein	NA	NA	NA	NA
WP_011543947.1\|1029711_1030950_-	peptidase T	NA	NA	NA	NA
WP_011543948.1\|1030993_1031791_-	Nif3-like dinuclear metal center hexameric protein	NA	NA	NA	NA
WP_011543949.1\|1031783_1032476_-	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_011543950.1\|1032619_1033060_+	8-oxo-dGTP diphosphatase	NA	NA	NA	NA
WP_011543951.1\|1033059_1033908_+	M23 family metallopeptidase	NA	NA	NA	NA
WP_011543953.1\|1035908_1036241_-	hypothetical protein	NA	NA	NA	NA
WP_011543954.1\|1039517_1041392_-	site-specific DNA-methyltransferase	A0A2K5B2C1	Erysipelothrix_phage	2.3e-104	36.4
WP_011543955.1\|1041384_1042008_-	DUF4391 domain-containing protein	NA	NA	NA	NA
WP_011543956.1\|1042008_1045245_-	helicase	A0A2K5B2B9	Erysipelothrix_phage	1.7e-232	43.7
WP_011543957.1\|1046323_1046503_-	hypothetical protein	NA	NA	NA	NA
WP_041806788.1\|1047822_1050060_-	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	3.1e-60	30.2
WP_011543961.1\|1052094_1053231_-	sigma-70 family RNA polymerase sigma factor	G8CLC7	Synechococcus_phage	1.6e-36	35.9
1050995:1051039	attR	NA	NA	NA	NA
WP_011543962.1\|1053266_1054385_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	2.9e-38	38.1
WP_011543963.1\|1054356_1056195_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	5.4e-58	37.4
WP_041806537.1\|1056226_1058293_-\|tRNA	glycine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_003618715.1\|1058285_1059197_-\|tRNA	glycine--tRNA ligase subunit alpha	NA	NA	NA	NA
WP_003613030.1\|1059461_1060211_-	DNA repair protein RecO	NA	NA	NA	NA
WP_011543965.1\|1060210_1061116_-	GTPase Era	NA	NA	NA	NA
WP_003618710.1\|1061099_1061519_-	cytidine deaminase	NA	NA	NA	NA
WP_003618709.1\|1061520_1062045_-	rRNA maturation RNase YbeY	NA	NA	NA	NA
WP_011543966.1\|1062044_1062992_-	PhoH family protein	H6X2N1	Pseudomonas_phage	8.9e-49	48.8
WP_002880182.1\|1063145_1063322_-	30S ribosomal protein S21	NA	NA	NA	NA
WP_003618707.1\|1063490_1064348_+	kinase/pyrophosphorylase	NA	NA	NA	NA
WP_011543967.1\|1064407_1064629_-	hypothetical protein	NA	NA	NA	NA
WP_011543968.1\|1064745_1065630_-	YitT family protein	NA	NA	NA	NA
WP_041806539.1\|1066784_1066985_-	hypothetical protein	NA	NA	NA	NA
WP_041806541.1\|1066993_1067305_-	hypothetical protein	NA	NA	NA	NA
WP_003618701.1\|1067548_1068733_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_041806543.1\|1068914_1070213_-	diaminopimelate decarboxylase	NA	NA	NA	NA
WP_011543969.1\|1070580_1071276_-	hypothetical protein	NA	NA	NA	NA
WP_077302027.1\|1071675_1071900_-	hypothetical protein	NA	NA	NA	NA
WP_002880191.1\|1072223_1073120_-	aldose 1-epimerase family protein	NA	NA	NA	NA
WP_011543971.1\|1073201_1074596_-\|protease	ATP-dependent protease ATPase subunit HslU	A0A1B2IB03	Erwinia_phage	1.9e-31	26.0
WP_003618695.1\|1074598_1075132_-\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_003618694.1\|1075241_1076129_-	tyrosine recombinase XerC	S5W9T9	Leptospira_phage	1.4e-24	30.2
WP_003618693.1\|1076128_1077448_-\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA
WP_011543972.1\|1077579_1079763_-	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	1.6e-93	34.8
WP_011543973.1\|1079889_1080729_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	2.4e-29	37.4
WP_003618690.1\|1080826_1081597_-	ribonuclease HII	G9E3X7	Emiliania_huxleyi_virus	5.6e-25	37.2
WP_003623895.1\|1081586_1082444_-	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_002880201.1\|1082518_1082749_-	YozE family protein	NA	NA	NA	NA
WP_011543974.1\|1082752_1083598_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	1.0e-19	45.0
WP_011543975.1\|1083732_1084395_+	hemolysin III family protein	NA	NA	NA	NA
WP_003618685.1\|1084420_1085611_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	2.4e-43	47.8
WP_011543976.1\|1085691_1086591_+	YitT family protein	M1Q1P6	Streptococcus_phage	2.6e-50	39.4

DBSCAN-SWA_4

1683521 : 1689709

Streptomyces_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041806712.1\|1683521_1684199_-	C40 family peptidase	A0A0A8WF62	Clostridium_phage	7.1e-16	40.5
WP_041806715.1\|1684377_1685160_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	1.0e-13	42.7
WP_011544282.1\|1686582_1687056_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	1.9e-15	41.9
WP_011544283.1\|1687226_1688273_-	lactate dehydrogenase	M1H502	Paramecium_bursaria_Chlorella_virus	1.8e-26	29.4
WP_003621166.1\|1688556_1689042_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	2.3e-16	41.1
WP_011544284.1\|1689166_1689709_-	AAA family ATPase	U5J9X2	Bacillus_phage	5.0e-12	34.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_008054

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection