CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_013947	Stackebrandtia nassauensis DSM 44728, complete sequence	19 crisprs	cas3,csa3,cas14j,DEDDh,WYL,c2c9_V-U4,Cas14u_CAS-V,cas7b,cas8c,cas5,cas4,Cas9_archaeal	2	15	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_013947_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_1

67879-67967

Orphan

Consensus_repeat	Method
GCTCGGGGTGGGCGGCTGTGCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_1

>merge|NC_013947|1|67879-67967|CRISPRCasFinder
GCTCGGGGTGGGCGGCTGTGCCTGGCCCCGGCCCAGAGCCAGAGCCAGAGTCAGAGCCGGGCCCAAGCTCGGGGTGGGTGGCTGTGCCT

>NC_013947|1|1|67879-67967|CRISPRCasFinder
GCTCGGGGTGGGCGGCTGTGCCT	GGCCCCGGCCCAGAGCCAGAGCCAGAGTCAGAGCCGGGCCCAA
GCTCGGGGTGGGTGGCTGTGCCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013015360.1\|74997_76455_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236940
NC_013947.1\|WP_013015362.1\|76951_77281_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015354.1\|66057_66840_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_013947.1\|WP_013015352.1\|64711_65290_+\|TIGR03086-family-protein	unknown	unknown	gnl\|CDD\|274424
NC_013947.1\|WP_013015363.1\|77298_78162_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015353.1\|65345_65903_-\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176864
NC_013947.1\|WP_169313833.1\|63234_63912_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NC_013947.1\|WP_013015348.1\|61543_62539_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015356.1\|67066_67744_-\|DUF998-domain-containing-protein	unknown	unknown	gnl\|CDD\|377627
NC_013947.1\|WP_013015355.1\|66836_67070_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015358.1\|71639_74444_-\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|276938
NC_013947.1\|WP_013015361.1\|76445_76973_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015365.1\|80611_82501_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368811
NC_013947.1\|WP_144300354.1\|74632_74989_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015364.1\|78288_80472_+\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NC_013947.1\|WP_013015351.1\|63971_64622_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013947.1\|WP_013015349.1\|62665_63208_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|236578
NC_013947.1\|WP_013015366.1\|82523_82979_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015347.1\|61313_61547_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015357.1\|68184_71487_-\|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX	unknown	unknown	gnl\|CDD\|235095

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013015360.1\|74997_76455_+\|hypothetical-protein	gnl\|CDD\|236940	PRK11633, PRK11633, cell division protein DedD; Provisional.	7.22481e-10
NC_013947.1\|WP_013015365.1\|80611_82501_+\|hypothetical-protein	gnl\|CDD\|368811	pfam06241, Castor_Poll_mid, Castor and Pollux, part of voltage-gated ion channel. This family represents a short region in the middle of largely plant proteins that belong to the TCDB:1.A.1.23.2 family of the voltage-gated ion channel superfamily, eg UniProtKB:Q5H8A6, Q5H8A5 and Q4VY51.	9.5712e-22
NC_013947.1\|WP_013015354.1\|66057_66840_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	2.58745e-13
NC_013947.1\|WP_013015352.1\|64711_65290_+\|TIGR03086-family-protein	gnl\|CDD\|274424	TIGR03086, TIGR03086, TIGR03086 family protein. This family, like pfam07398 and TIGRFAMs family TIGR030834, belongs to the larger set of probable enzymes defined in family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized.	9.50074e-24
NC_013947.1\|WP_013015353.1\|65345_65903_-\|SRPBCC-domain-containing-protein	gnl\|CDD\|176864	cd07822, SRPBCC_4, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	2.49195e-47
NC_013947.1\|WP_169313833.1\|63234_63912_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	1.94583e-13
NC_013947.1\|WP_013015364.1\|78288_80472_+\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	3.79774e-85
NC_013947.1\|WP_013015356.1\|67066_67744_-\|DUF998-domain-containing-protein	gnl\|CDD\|377627	pfam06197, DUF998, Protein of unknown function (DUF998). Family of conserved archaeal proteins.	6.47413e-10
NC_013947.1\|WP_013015351.1\|63971_64622_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	7.96353e-07
NC_013947.1\|WP_013015358.1\|71639_74444_-\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	4.78564e-41
NC_013947.1\|WP_013015349.1\|62665_63208_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|236578	PRK09583, PRK09583, mycothiol-dependent maleylpyruvate isomerase; Reviewed.	1.97094e-55
NC_013947.1\|WP_013015357.1\|68184_71487_-\|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX	gnl\|CDD\|235095	PRK02983, lysS, bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX.	0

>NC_013947.1|WP_013015356.1|67066_67744_-|DUF998-domain-containing-protein
MAIALLASGVVYASWLLGGWVNPGLGPVVSYASELAASDQPGSLAFRIGDLVAGAAACVAGLWALRRRPWLGWACVVAFGVFTMLDAGLFNMSCAPSLDPTCATAEVAGKVPLRHQIHTLSSSLAAAAPFVGLIAFAWAWRTVTAWVLSGLMVAATAATMLAVATDHLVGVAQRLQLLIVSAWLVWLALRTWRATSSDPTAARTATANLAPSEQPTAVDTNGARP
>NC_013947.1|WP_013015355.1|66836_67070_-|hypothetical-protein
MTHIAVHDRPTTDAAGSQPREPRRQPRPISHRRGKTEDCVINPSAAHSQQLTNAREPGMAAIAVHERPTTHAAGSRA
>NC_013947.1|WP_013015354.1|66057_66840_-|alpha/beta-fold-hydrolase
MSDVVILTGLADSRWTWRPVETALADAGTVLIADRTRHQTFPTLADEIVRVRDLVVGHRLGPPVVVAHSFGALIAEAYARRYPVAGLVLVDPSWDPDATGRGAIEAGLVRAAFHGAGALGKALDVTGLARHLGPALWSLSLRAVALRRPGAGVVAATRSVYRRGETLVAAAAEELAFRDFAAALAKSRATSHAPEVPVVVLTAVGTDPKSRDSRHWIAAHRRLAALFPNGRHEVVRGAKHMMHIDRPEVIVREVNRLLAG
>NC_013947.1|WP_013015353.1|65345_65903_-|SRPBCC-domain-containing-protein
MPPSDPPDPPPKPRKLRNRILIGLSVLVVLLAGYTAWANLHVYTLTASIDIDAPPDKVWEVLVDRESYPDWNPFLVSSKGGLKEGGTITNLMRGADGTETEFTPTVLVVEPGKELRWIGKLSPGLLFDGEHSFRLIKRGSGTRLIQSEDFTGALVPPMQSWLDGDTLPQFKAMNKALKKRAEAGG
>NC_013947.1|WP_013015352.1|64711_65290_+|TIGR03086-family-protein
MDHRQQYRQAQLDLVDIVRNLKDEDLDAPTTCSGWTVRDILKHVTQNAYSTAAKLRDEEYDPETDERLGNDLREEFPLASDAAWEYNKQDKVLEQKIQFAGTEQPGWVALAFQFADILVHQWDISHSLSRPITLRPDAVADATTIAGMIPDGDEFRGPGKPFGRIVATDSDDPQDKLLAITGRDPRWTPAAA
>NC_013947.1|WP_013015351.1|63971_64622_-|TetR/AcrR-family-transcriptional-regulator
MECESRTDGRLERGNAKRRAILDRAVDLASISGLDGLSIGKLAAELGISKSGALLHFGSKLELQLDVITHAAERFGRAVIAPAAEQPVGLPRLWYLTDGWLHHIEIETFPGGCFFSTVGAEFNSRPGRIHDALAKIHNRWSNLLEQQAVAAREAGQLRPDVVAERLVFELDALIRHANMHRQLHDSRKVLGHAREAVRDLLTRVGTEAAVRELFGE
>NC_013947.1|WP_169313833.1|63234_63912_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MTDNPFDRLDAETRRVDAFLSGLSPDEWRVESRCPGWDRKAMLAHLSGIEDYIRAGLDGTVDAYANQAGQGVGYEQLNEFLIRRHAETPTDELLRRWREQVAESHPRLRERGVDAVIDTQAGEYPLGRQTWFFACEYAIHADDIAVPVTEAERDDRLAWRLEFARDALAEYGKGVTVEPSGDGYEVSFGDEKARLSTADLVEATSGRLDEDRLPERLRRRLVVLA
>NC_013947.1|WP_013015349.1|62665_63208_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MSAQRTEALALLGPATDRLIDTVRGLSDAQLRADSLLPGWSRGHVLTHVARQADAMCNLLTWASTGVETPAYASQESRAADIEAGSGRSADELVADLRASAERFLAKVAETSDDAWGAQVRVLNSELFPAEQTVSRRLAEVELHHVDLGLEYRAADWPKQFADIELPEPSATFRAERASW
>NC_013947.1|WP_013015348.1|61543_62539_+|hypothetical-protein
MNRREGRRTRWLAVLLLLVLSPVCAEYIQAYDDSTGNPVALLGALLVFVPLYGAPAVLIRELARRFDVRWPGILALTTGFGILQAGVIDQSMFDTGYRGIDYWDDMIMPTWIEPLGISVNASLAFVLGHAIWSFGVPIALSEAISGRYSRTPWLRWPGLSVLVVLYLAAAALIMVGEDSGGASSGQLVGALAVTAALALFAFTLGRRRRDRRDRRVPAPLLVFAVAAPVSFGFNMLGYSISDTVIVVGLLVAVAAAVTYLSGSRAWTGRHVAALASGTLLGRVGIGFLTDPLGDVSAVAHAGHSVFFLLMALGLWLLADRRSRATPATDVA
>NC_013947.1|WP_013015347.1|61313_61547_+|hypothetical-protein
MRKVLQVLGLYLVIAGISGTLDHVAIQPIMGVVFNAFNRFLLPHLDALKGYEVPANLSLSVVGAVLLLAVGRREKTA
>NC_013947.1|WP_013015357.1|68184_71487_-|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX
MTTVNKSAPGGWRARIPTVLATLMALLTLIVALAAVASAFRDRTVKVREFVEMVLIPAPPNLAYAAFLAIFAAAVARRKRLAWWILVGYFSLTLVLLALLNTIVILAPAFVFADPASVEDTPGYVVPRLVLATFIAIVLLVLLLVGRSQFPARVGRGSLWKAIGVLAALMAMFVLIGWGLVSMFPGTVTHGDRFQYTFDKVVGGALRFEMTRSGVAPGWIDLLLGAFGAVALLAALFTLFKSQRLAAAMNAWDEVRLRVLLAAHGEDDSLGYFATRRDKAVIYAPGETAAVTYRTVTGVCLASGDPIGDPADWPKAIDAWLRQARGHGWVPAVLGASEAGATAYRQAGLRVREIGDEAILLPREYTLDGREMRPVRQAVARIERAGYTARIRRHGELSASEMAAAIKRADDWRDTKTERGFSMALSRFGDADDADNVLVEAIDGIGKVRAMLSFVPWGRRGLSLDLMRRERDADNGLMEFMVTSLCREAGRLGVDRISLNFAMFRAVFEEGARIGAGPILRWWRRLLTFFSRWWQLESLYRSNVKYRPHWAPRYLCYGERRALGRVGLAAAVAEGFLSADISRVSIGRAARAKPLPGLAEALAEAATTPTVDPRTRLPEQMRVRLDKLDRLRDAGVEPYPVGFERTLACGQVARDFPDLPPDANTGRFVAVAGRVMLLRHHGKLSFATIRDWTGDLQVMVVGDSDFRHTVDIGDHLGVEGEVVTSKRGELSVLSKKWTLTAKCLHPLPDKHLGLADPEAKVRQRHLDLIVSPQARTDLRARGAVIHSLRTGLHDDGYLEVETPILQAIHGGANARPFVTHINAYDMRLYLRIAPELYLKRLCVGGVEKVFELGRTFRNEGVSFKHNPEFTMLEAYQSYADYNTMRELTMRLVRQAAVAAFDTTVITRDDHEIDLAADWPVIPIHQAISTALGEHIDPGTPRDKLRQLCEAADIPLDPQWDEGAIVLEMYERLVEHATTAPTFYSDFPTSVSPLTRQHRTDPRLAERWDLVAFGTEIGTAYSELIDPVEQRRRLTEQSLLAAGGDPEAMELDEDFLAALEYAMPPTGGLGIGVDRLVMLLTGNGIRQTLPFPLVKPTVDQP
>NC_013947.1|WP_013015358.1|71639_74444_-|AfsR/SARP-family-transcriptional-regulator
MRFETLGPLRVSDESGVLPLRGRKARVLLAVLVSRAGDAVPIDVLARAIWDDKVPDTAIKTLRWHIHQLRRLLGDANRITYDDGGYRLRADPSEVDSFGFERLCADGFAAQRSRDPVIAARCFTEALKLWRGPAFGDLVDCGILRDEAARLDQLYLDATEQRHGVELDLGNHEEVLAELTELVERYPLRENLRAHLMVALYRCGRRSEALEMFRAGRELFAEQLGLDPAPRLRELEKAILNSDPALDPPSATRSGPAELPRDIATFTGREAEVSELTELLVTDSMTPLVISSINGGGGVGKSALAIHLGHLVRERFPDGQLYVNLQGATPNAEPLEPAEVLRRFLRSLGVGGDDGISEVAELANRLRTATNGKRMLFLLDDARDSGQVRPLLPSEPRCAVLITSRRTLSTLDGSVNRALDGLSDADAVTLLERLVGTDRVAAEPEAVRRLLGWCGGMPLALRICAARLVARPRWSVASLADELADETRRLSELEVDDLAIRSSFAVGYRQLCEDSASAARVFRLLGLHDGPDFTTRHVAALAELDEPDAERSLAELTATHLVEPAGPGRYRTHDLMRLFARERVTAEESAAERRASVERERRFYLGTVRNMLGVCEPGMRNRLGLVPEEFVRHGVRFEDAKSAYAWAMADTANLLAICRAAIGGGATDDPDFTATTVTVLGPVLVIRGSAGPMADLHELGIKARKWVTKPDLRFFISTGAAELMRVAGKHDEALRHLEVAMSISREQGWRVREGWILVGVGTMYWWMGELDQATDHLDRAVAIAAETGDRALEGSATSHLGHVHAESGRHDAAIEAMRKVLAFAQDSGRPRGRVEGMISLGRVYQLADRPTEARDCYERATAMLDETGLAGTRYEAEALWGLADAGHALGETELTRERWDRAAKLLFDLKLIDAGERDHIISVPEPDRPKAIRY
>NC_013947.1|WP_144300354.1|74632_74989_+|hypothetical-protein
MRTDNVFALAEALRADAERFRTDANRIMREIQGEEGGSRYYGADPRNVPAAQTMNRHDEVRRAAEKLVADVAAGFTGMSRSTRAVIHAFRNQDGLNAAKVRRVRDVLRLPREHGEGPV
>NC_013947.1|WP_013015360.1|74997_76455_+|hypothetical-protein
MGEFDAYDIDELAEMVSRDRPGGLFDQAAGWRKLHRLLDGYATRLSERLDQARPSWAGAAADVYFAELRARHDELRWASDTADFNASAWDRIASNAARSQGEVLRIQQEWRDVDGSEPTDGTESRLREERRRSYDEAARAVMDEVSGDNDLSRAAMADHHQFTPMPGVDLPEDHPVEPRDPGEPRGPVNPRDPRDPVNPPSGRGPELQGPGGAPPAPQPASVLPPDPGPAPGPRPVPVPTPTPVPGPRPTPVPRPGPGSGPGPKPTPAPRPGLGPRPTPTPAPRPGVTPRPVPGTRPTPRPPGPTVRPVIGSRPGTNVPGPGTRVPGSLTRPVIGSRPAVGGTEAPKALIGKDGVAGRRGTGATPGVRSSTSHFGGGGLNRPVVGSSRAKPASGAAPGPGGRVGRRRGDDETNHGDGPLGEFWTPGRTVPSVITSRPTVEHDPGPVSQLGRRRPRAETTPDEETLWSPPMSHQEGLSRKDAERWI
>NC_013947.1|WP_013015361.1|76445_76973_+|hypothetical-protein
MDLTLERLNVMATSPDKSVQARMSNAAGLQVKLEPGTVDRHTERSLGTQLTAAVNGAITGYRKGAAKAFGVLRAQWGMPSRSDADPELQDEPQTVTTSGAGNVSVRMRGETVTAVGLHPGTLRRISEPELLDELRDALLSAMTRHAELITAKSRTTATATPRPLERTASWRTTSK
>NC_013947.1|WP_013015362.1|76951_77281_+|hypothetical-protein
MADDIEVVLTNLNRIARNELPPIITNTSTASQEIKSGLEGIEPAFDGDVFGPTLEAFQSTVTSVCAELDKANERVKDTVHAVIEVLGAYRAVDGANARSITATTSPVGE
>NC_013947.1|WP_013015363.1|77298_78162_+|hypothetical-protein
MTNMTGAIHEAVDAIGTAIIYAESRKGSWVFEQQEWLDFVRELSPLMHHQYGRLANCDPSPAKAASKRIESGKTSLAKNANPNGSLESQTKRIKKLCETWRSDGGYAFHSHIGKMEFALLHQQEMAAVLSSLMELHSSHVLATQEDLLNIANLTIDSLERHGYDIQQKERQKLGAILDTLVSVASGGIVGSLGSGAAKAVGEAVSGIKGSSAVSAAMQLPTDDTMLIIKTMKRKVDQLIEQTTAQQSQIRVALTSVFEAYVDKPIMLPPEVATGTLSDQDWRYATRR
>NC_013947.1|WP_013015364.1|78288_80472_+|(Fe-S)-binding-protein
MGVVQIVATLIAAVVTIVAITVFARTGMSMVRIIKLGAPDPTRRNKGAVRLKTMLRETVGHTRMLKWTLVGAAHWFVFVAFITLFPVLVEAYLKVINPTWTLPFVGHWSLWLLYTETIGALGIAGIVALFVVRMLNQPRNNPAPERPEGTELSEAHTRTSTSRFERSRQWQGFYIEATIFGIIASHFITRSLKVAAGELDVPAWAAPISNAIGGAMSGLGEAALTPITIVALVEIIISWLFFYILGRNITMGLGWHRITAFFNIYFKRNADGPVSLGAAKPLMVRGEPIDFENADPETDPFGVGQVEQFTWKGLLDFTTCTECGRCQSQCPAWNTDKPLSPKLLITDLREHLYAKAPYLLAGGGKDALGEETGTAEQLKDVPADALAEAEKSLVGDVIDPDVLWSCTTCGACVEQCPVDIEHVDHIVDMRRHQVMIESAFPSEAQTLMRNLENKGNPWGAAPNTREDWTKGLDFEVPRVDSASPDFEYLFWVGCAGAFDDKAVKTTQAVATLLYEAEVKYAILGNGETCTGDPARRSGNEFLFSMLAEQNVETLNEAKVTKIVATCPHCLNTLGNEYGQLGGNYEVIHHTELLSNLIAERRLKPVTKLENGVTYHDPCYLGRHNRVFSPPRELLGEVSATGLTEMPRNSEKSFCCGAGGARMWMEEKIGTRININRSTEAVETGAKTVAVACPFCSTMINDGVNAVGAGDDVEVVDVAQILLRNTRE
>NC_013947.1|WP_013015365.1|80611_82501_+|hypothetical-protein
MSKPTFRQRARYWFDNTMSKGTKALISWLTIITLVVVAIGAGLAVLASLIDPKAEDEGFAANLWTAFIHVIDPGTITGDTSTPLFIGMMLVITIGGLVIISSLVGILTTGLDAKLEELRKGRSLVVESGHTVVLGWSDQVFTVISELVEANESEKRACIAILADRDKVEMEDEIRAKLSDLKTTKVVCRTGDPADPDDIAIVNPEQAKGIVLLTSNEEDPDAQLVRSLLAVTEGGQKTDGPHVVGAVTDSRNLPAARLAGGPRAQVVDGDDIMARLMVQTCRQSGLSVVYTDLLDFGGDEMYMVEEPRLVGCTVQQVVHAYRVSSFMGIYNPNTGSRINPPSSTVVNPGDRLIMLSEDDSTIVLDGAQPYIEEKAIVARGEHGSRPERTLILGWNARTPTVLEQLDAYVSRGSTTDVVSDHGDMSTQLRRLGPQMKVQSVNFKEDDTTSRALLESLNVASYDHVIVLCRDDVPAQLADSKTLVTLLHLRDMAEKSGQRYKVVSEMADDRNRGLAQVTQADDFIVSEKLISLMLTQTAENPHLSQVFNDLFDPDGSEIYLKPCEYYVRPGMPLNFYTVAESARRRGETAIGYRQAALSSQAPTFGVVLNPDKAAGFTMQAGDKVIVLAED
>NC_013947.1|WP_013015366.1|82523_82979_-|hypothetical-protein
MDNNFDFLVGTWTSKQRRLREILNGCDEWYEFTGDLKCWSIWDGAGNIDEVTFPDQGYSGVTVRLYDAKTDEWSLYWASSRSPMALPPQVGRFVDGRGEFYADDVFNGEKIKVVFIWSNITATTARWEQAFSRDGGETWETNWVADFTRTS

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Crispr_ID: NC_013947_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_2

75865-76010

Orphan

Consensus_repeat	Method
CGTCCGGTGATCGGCTCCCGCCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_013947_2

>merge|NC_013947|2|75865-76010|CRISPRCasFinder
CGACCGGTACCGGGCACCCGGCCGACCCCTCGGCCGCCGGGCCCCACGGTGCGTCCGGTGATCGGCTCCCGCCCCGGCACCAACGTTCCCGGACCGGGCACCCGGGTCCCGGGTTCGCTGACCCGTCCGGTGATCGGCTCCCGCCC

>NC_013947|2|2|75865-76010|CRISPRCasFinder
CGACCGGTACCGGGCACCCGGCC	GACCCCTCGGCCGCCGGGCCCCACGGTG
CGTCCGGTGATCGGCTCCCGCCC	CGGCACCAACGTTCCCGGACCGGGCACCCGGGTCCCGGGTTCGCTGACC
CGTCCGGTGATCGGCTCCCGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013015369.1\|85183_85999_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133031
NC_013947.1\|WP_013015368.1\|84066_85125_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_013947.1\|WP_083786973.1\|83016_83943_-\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|132002
NC_013947.1\|WP_013015362.1\|76951_77281_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015354.1\|66057_66840_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_013947.1\|WP_013015352.1\|64711_65290_+\|TIGR03086-family-protein	unknown	unknown	gnl\|CDD\|274424
NC_013947.1\|WP_013015363.1\|77298_78162_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015353.1\|65345_65903_-\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176864
NC_013947.1\|WP_169313833.1\|63234_63912_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NC_013947.1\|WP_013015364.1\|78288_80472_+\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NC_013947.1\|WP_013015356.1\|67066_67744_-\|DUF998-domain-containing-protein	unknown	unknown	gnl\|CDD\|377627
NC_013947.1\|WP_013015355.1\|66836_67070_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015358.1\|71639_74444_-\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|276938
NC_013947.1\|WP_013015361.1\|76445_76973_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015365.1\|80611_82501_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368811
NC_013947.1\|WP_144300354.1\|74632_74989_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015370.1\|85995_87753_+\|glycosyl-transferase	unknown	unknown	gnl\|CDD\|378217
NC_013947.1\|WP_013015351.1\|63971_64622_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013947.1\|WP_013015366.1\|82523_82979_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013015357.1\|68184_71487_-\|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX	unknown	unknown	gnl\|CDD\|235095

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013015368.1\|84066_85125_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	2.65935e-58
NC_013947.1\|WP_083786973.1\|83016_83943_-\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	9.1109e-123
NC_013947.1\|WP_013015365.1\|80611_82501_+\|hypothetical-protein	gnl\|CDD\|368811	pfam06241, Castor_Poll_mid, Castor and Pollux, part of voltage-gated ion channel. This family represents a short region in the middle of largely plant proteins that belong to the TCDB:1.A.1.23.2 family of the voltage-gated ion channel superfamily, eg UniProtKB:Q5H8A6, Q5H8A5 and Q4VY51.	9.5712e-22
NC_013947.1\|WP_013015354.1\|66057_66840_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	2.58745e-13
NC_013947.1\|WP_013015352.1\|64711_65290_+\|TIGR03086-family-protein	gnl\|CDD\|274424	TIGR03086, TIGR03086, TIGR03086 family protein. This family, like pfam07398 and TIGRFAMs family TIGR030834, belongs to the larger set of probable enzymes defined in family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized.	9.50074e-24
NC_013947.1\|WP_013015353.1\|65345_65903_-\|SRPBCC-domain-containing-protein	gnl\|CDD\|176864	cd07822, SRPBCC_4, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	2.49195e-47
NC_013947.1\|WP_169313833.1\|63234_63912_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	1.94583e-13
NC_013947.1\|WP_013015364.1\|78288_80472_+\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	3.79774e-85
NC_013947.1\|WP_013015356.1\|67066_67744_-\|DUF998-domain-containing-protein	gnl\|CDD\|377627	pfam06197, DUF998, Protein of unknown function (DUF998). Family of conserved archaeal proteins.	6.47413e-10
NC_013947.1\|WP_013015358.1\|71639_74444_-\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	4.78564e-41
NC_013947.1\|WP_013015369.1\|85183_85999_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133031	cd04188, DPG_synthase, DPG_synthase is involved in protein N-linked glycosylation. UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.	3.54346e-84
NC_013947.1\|WP_013015370.1\|85995_87753_+\|glycosyl-transferase	gnl\|CDD\|378217	pfam09594, GT87, Glycosyltransferase family 87. The enzymes in this family are glycosyltransferases. PimE is involved in phosphatidylinositol mannoside (PIM) synthesis, a major class of glycolipids in all mycobacteria. PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of PIM. The family also includes alpha(1-->3) arabinofuranosyltransferase, invloved in the synthesis of of mycobacterial arabinogalactan.	0.0046001
NC_013947.1\|WP_013015351.1\|63971_64622_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	7.96353e-07
NC_013947.1\|WP_013015357.1\|68184_71487_-\|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX	gnl\|CDD\|235095	PRK02983, lysS, bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX.	0

>NC_013947.1|WP_144300354.1|74632_74989_+|hypothetical-protein
MRTDNVFALAEALRADAERFRTDANRIMREIQGEEGGSRYYGADPRNVPAAQTMNRHDEVRRAAEKLVADVAAGFTGMSRSTRAVIHAFRNQDGLNAAKVRRVRDVLRLPREHGEGPV
>NC_013947.1|WP_013015358.1|71639_74444_-|AfsR/SARP-family-transcriptional-regulator
MRFETLGPLRVSDESGVLPLRGRKARVLLAVLVSRAGDAVPIDVLARAIWDDKVPDTAIKTLRWHIHQLRRLLGDANRITYDDGGYRLRADPSEVDSFGFERLCADGFAAQRSRDPVIAARCFTEALKLWRGPAFGDLVDCGILRDEAARLDQLYLDATEQRHGVELDLGNHEEVLAELTELVERYPLRENLRAHLMVALYRCGRRSEALEMFRAGRELFAEQLGLDPAPRLRELEKAILNSDPALDPPSATRSGPAELPRDIATFTGREAEVSELTELLVTDSMTPLVISSINGGGGVGKSALAIHLGHLVRERFPDGQLYVNLQGATPNAEPLEPAEVLRRFLRSLGVGGDDGISEVAELANRLRTATNGKRMLFLLDDARDSGQVRPLLPSEPRCAVLITSRRTLSTLDGSVNRALDGLSDADAVTLLERLVGTDRVAAEPEAVRRLLGWCGGMPLALRICAARLVARPRWSVASLADELADETRRLSELEVDDLAIRSSFAVGYRQLCEDSASAARVFRLLGLHDGPDFTTRHVAALAELDEPDAERSLAELTATHLVEPAGPGRYRTHDLMRLFARERVTAEESAAERRASVERERRFYLGTVRNMLGVCEPGMRNRLGLVPEEFVRHGVRFEDAKSAYAWAMADTANLLAICRAAIGGGATDDPDFTATTVTVLGPVLVIRGSAGPMADLHELGIKARKWVTKPDLRFFISTGAAELMRVAGKHDEALRHLEVAMSISREQGWRVREGWILVGVGTMYWWMGELDQATDHLDRAVAIAAETGDRALEGSATSHLGHVHAESGRHDAAIEAMRKVLAFAQDSGRPRGRVEGMISLGRVYQLADRPTEARDCYERATAMLDETGLAGTRYEAEALWGLADAGHALGETELTRERWDRAAKLLFDLKLIDAGERDHIISVPEPDRPKAIRY
>NC_013947.1|WP_013015357.1|68184_71487_-|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX
MTTVNKSAPGGWRARIPTVLATLMALLTLIVALAAVASAFRDRTVKVREFVEMVLIPAPPNLAYAAFLAIFAAAVARRKRLAWWILVGYFSLTLVLLALLNTIVILAPAFVFADPASVEDTPGYVVPRLVLATFIAIVLLVLLLVGRSQFPARVGRGSLWKAIGVLAALMAMFVLIGWGLVSMFPGTVTHGDRFQYTFDKVVGGALRFEMTRSGVAPGWIDLLLGAFGAVALLAALFTLFKSQRLAAAMNAWDEVRLRVLLAAHGEDDSLGYFATRRDKAVIYAPGETAAVTYRTVTGVCLASGDPIGDPADWPKAIDAWLRQARGHGWVPAVLGASEAGATAYRQAGLRVREIGDEAILLPREYTLDGREMRPVRQAVARIERAGYTARIRRHGELSASEMAAAIKRADDWRDTKTERGFSMALSRFGDADDADNVLVEAIDGIGKVRAMLSFVPWGRRGLSLDLMRRERDADNGLMEFMVTSLCREAGRLGVDRISLNFAMFRAVFEEGARIGAGPILRWWRRLLTFFSRWWQLESLYRSNVKYRPHWAPRYLCYGERRALGRVGLAAAVAEGFLSADISRVSIGRAARAKPLPGLAEALAEAATTPTVDPRTRLPEQMRVRLDKLDRLRDAGVEPYPVGFERTLACGQVARDFPDLPPDANTGRFVAVAGRVMLLRHHGKLSFATIRDWTGDLQVMVVGDSDFRHTVDIGDHLGVEGEVVTSKRGELSVLSKKWTLTAKCLHPLPDKHLGLADPEAKVRQRHLDLIVSPQARTDLRARGAVIHSLRTGLHDDGYLEVETPILQAIHGGANARPFVTHINAYDMRLYLRIAPELYLKRLCVGGVEKVFELGRTFRNEGVSFKHNPEFTMLEAYQSYADYNTMRELTMRLVRQAAVAAFDTTVITRDDHEIDLAADWPVIPIHQAISTALGEHIDPGTPRDKLRQLCEAADIPLDPQWDEGAIVLEMYERLVEHATTAPTFYSDFPTSVSPLTRQHRTDPRLAERWDLVAFGTEIGTAYSELIDPVEQRRRLTEQSLLAAGGDPEAMELDEDFLAALEYAMPPTGGLGIGVDRLVMLLTGNGIRQTLPFPLVKPTVDQP
>NC_013947.1|WP_013015356.1|67066_67744_-|DUF998-domain-containing-protein
MAIALLASGVVYASWLLGGWVNPGLGPVVSYASELAASDQPGSLAFRIGDLVAGAAACVAGLWALRRRPWLGWACVVAFGVFTMLDAGLFNMSCAPSLDPTCATAEVAGKVPLRHQIHTLSSSLAAAAPFVGLIAFAWAWRTVTAWVLSGLMVAATAATMLAVATDHLVGVAQRLQLLIVSAWLVWLALRTWRATSSDPTAARTATANLAPSEQPTAVDTNGARP
>NC_013947.1|WP_013015355.1|66836_67070_-|hypothetical-protein
MTHIAVHDRPTTDAAGSQPREPRRQPRPISHRRGKTEDCVINPSAAHSQQLTNAREPGMAAIAVHERPTTHAAGSRA
>NC_013947.1|WP_013015354.1|66057_66840_-|alpha/beta-fold-hydrolase
MSDVVILTGLADSRWTWRPVETALADAGTVLIADRTRHQTFPTLADEIVRVRDLVVGHRLGPPVVVAHSFGALIAEAYARRYPVAGLVLVDPSWDPDATGRGAIEAGLVRAAFHGAGALGKALDVTGLARHLGPALWSLSLRAVALRRPGAGVVAATRSVYRRGETLVAAAAEELAFRDFAAALAKSRATSHAPEVPVVVLTAVGTDPKSRDSRHWIAAHRRLAALFPNGRHEVVRGAKHMMHIDRPEVIVREVNRLLAG
>NC_013947.1|WP_013015353.1|65345_65903_-|SRPBCC-domain-containing-protein
MPPSDPPDPPPKPRKLRNRILIGLSVLVVLLAGYTAWANLHVYTLTASIDIDAPPDKVWEVLVDRESYPDWNPFLVSSKGGLKEGGTITNLMRGADGTETEFTPTVLVVEPGKELRWIGKLSPGLLFDGEHSFRLIKRGSGTRLIQSEDFTGALVPPMQSWLDGDTLPQFKAMNKALKKRAEAGG
>NC_013947.1|WP_013015352.1|64711_65290_+|TIGR03086-family-protein
MDHRQQYRQAQLDLVDIVRNLKDEDLDAPTTCSGWTVRDILKHVTQNAYSTAAKLRDEEYDPETDERLGNDLREEFPLASDAAWEYNKQDKVLEQKIQFAGTEQPGWVALAFQFADILVHQWDISHSLSRPITLRPDAVADATTIAGMIPDGDEFRGPGKPFGRIVATDSDDPQDKLLAITGRDPRWTPAAA
>NC_013947.1|WP_013015351.1|63971_64622_-|TetR/AcrR-family-transcriptional-regulator
MECESRTDGRLERGNAKRRAILDRAVDLASISGLDGLSIGKLAAELGISKSGALLHFGSKLELQLDVITHAAERFGRAVIAPAAEQPVGLPRLWYLTDGWLHHIEIETFPGGCFFSTVGAEFNSRPGRIHDALAKIHNRWSNLLEQQAVAAREAGQLRPDVVAERLVFELDALIRHANMHRQLHDSRKVLGHAREAVRDLLTRVGTEAAVRELFGE
>NC_013947.1|WP_169313833.1|63234_63912_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MTDNPFDRLDAETRRVDAFLSGLSPDEWRVESRCPGWDRKAMLAHLSGIEDYIRAGLDGTVDAYANQAGQGVGYEQLNEFLIRRHAETPTDELLRRWREQVAESHPRLRERGVDAVIDTQAGEYPLGRQTWFFACEYAIHADDIAVPVTEAERDDRLAWRLEFARDALAEYGKGVTVEPSGDGYEVSFGDEKARLSTADLVEATSGRLDEDRLPERLRRRLVVLA
>NC_013947.1|WP_013015361.1|76445_76973_+|hypothetical-protein
MDLTLERLNVMATSPDKSVQARMSNAAGLQVKLEPGTVDRHTERSLGTQLTAAVNGAITGYRKGAAKAFGVLRAQWGMPSRSDADPELQDEPQTVTTSGAGNVSVRMRGETVTAVGLHPGTLRRISEPELLDELRDALLSAMTRHAELITAKSRTTATATPRPLERTASWRTTSK
>NC_013947.1|WP_013015362.1|76951_77281_+|hypothetical-protein
MADDIEVVLTNLNRIARNELPPIITNTSTASQEIKSGLEGIEPAFDGDVFGPTLEAFQSTVTSVCAELDKANERVKDTVHAVIEVLGAYRAVDGANARSITATTSPVGE
>NC_013947.1|WP_013015363.1|77298_78162_+|hypothetical-protein
MTNMTGAIHEAVDAIGTAIIYAESRKGSWVFEQQEWLDFVRELSPLMHHQYGRLANCDPSPAKAASKRIESGKTSLAKNANPNGSLESQTKRIKKLCETWRSDGGYAFHSHIGKMEFALLHQQEMAAVLSSLMELHSSHVLATQEDLLNIANLTIDSLERHGYDIQQKERQKLGAILDTLVSVASGGIVGSLGSGAAKAVGEAVSGIKGSSAVSAAMQLPTDDTMLIIKTMKRKVDQLIEQTTAQQSQIRVALTSVFEAYVDKPIMLPPEVATGTLSDQDWRYATRR
>NC_013947.1|WP_013015364.1|78288_80472_+|(Fe-S)-binding-protein
MGVVQIVATLIAAVVTIVAITVFARTGMSMVRIIKLGAPDPTRRNKGAVRLKTMLRETVGHTRMLKWTLVGAAHWFVFVAFITLFPVLVEAYLKVINPTWTLPFVGHWSLWLLYTETIGALGIAGIVALFVVRMLNQPRNNPAPERPEGTELSEAHTRTSTSRFERSRQWQGFYIEATIFGIIASHFITRSLKVAAGELDVPAWAAPISNAIGGAMSGLGEAALTPITIVALVEIIISWLFFYILGRNITMGLGWHRITAFFNIYFKRNADGPVSLGAAKPLMVRGEPIDFENADPETDPFGVGQVEQFTWKGLLDFTTCTECGRCQSQCPAWNTDKPLSPKLLITDLREHLYAKAPYLLAGGGKDALGEETGTAEQLKDVPADALAEAEKSLVGDVIDPDVLWSCTTCGACVEQCPVDIEHVDHIVDMRRHQVMIESAFPSEAQTLMRNLENKGNPWGAAPNTREDWTKGLDFEVPRVDSASPDFEYLFWVGCAGAFDDKAVKTTQAVATLLYEAEVKYAILGNGETCTGDPARRSGNEFLFSMLAEQNVETLNEAKVTKIVATCPHCLNTLGNEYGQLGGNYEVIHHTELLSNLIAERRLKPVTKLENGVTYHDPCYLGRHNRVFSPPRELLGEVSATGLTEMPRNSEKSFCCGAGGARMWMEEKIGTRININRSTEAVETGAKTVAVACPFCSTMINDGVNAVGAGDDVEVVDVAQILLRNTRE
>NC_013947.1|WP_013015365.1|80611_82501_+|hypothetical-protein
MSKPTFRQRARYWFDNTMSKGTKALISWLTIITLVVVAIGAGLAVLASLIDPKAEDEGFAANLWTAFIHVIDPGTITGDTSTPLFIGMMLVITIGGLVIISSLVGILTTGLDAKLEELRKGRSLVVESGHTVVLGWSDQVFTVISELVEANESEKRACIAILADRDKVEMEDEIRAKLSDLKTTKVVCRTGDPADPDDIAIVNPEQAKGIVLLTSNEEDPDAQLVRSLLAVTEGGQKTDGPHVVGAVTDSRNLPAARLAGGPRAQVVDGDDIMARLMVQTCRQSGLSVVYTDLLDFGGDEMYMVEEPRLVGCTVQQVVHAYRVSSFMGIYNPNTGSRINPPSSTVVNPGDRLIMLSEDDSTIVLDGAQPYIEEKAIVARGEHGSRPERTLILGWNARTPTVLEQLDAYVSRGSTTDVVSDHGDMSTQLRRLGPQMKVQSVNFKEDDTTSRALLESLNVASYDHVIVLCRDDVPAQLADSKTLVTLLHLRDMAEKSGQRYKVVSEMADDRNRGLAQVTQADDFIVSEKLISLMLTQTAENPHLSQVFNDLFDPDGSEIYLKPCEYYVRPGMPLNFYTVAESARRRGETAIGYRQAALSSQAPTFGVVLNPDKAAGFTMQAGDKVIVLAED
>NC_013947.1|WP_013015366.1|82523_82979_-|hypothetical-protein
MDNNFDFLVGTWTSKQRRLREILNGCDEWYEFTGDLKCWSIWDGAGNIDEVTFPDQGYSGVTVRLYDAKTDEWSLYWASSRSPMALPPQVGRFVDGRGEFYADDVFNGEKIKVVFIWSNITATTARWEQAFSRDGGETWETNWVADFTRTS
>NC_013947.1|WP_083786973.1|83016_83943_-|RNA-polymerase-sigma-70-factor
MWVAPSTAHRQEPPMTAGRAETGPDAATDAFVAHRNLLFTVAYELLGSAVDAEDVLQETWLRWADVDLDTVRDHRAYLVRIATRQALNRLRTLSRRKESYVGPWLPEPLLTTPDVAEDVELADSLSTAMLLVLETLTPTERAVFVLRDVFALDYDEIAEAVDKTPAAVRKVAHRARSHVAARRPRGEVSPAQSRAALEAFRSAVATGDLQGLVDILAPDMVMLSDGGGIVTALPNPIVGADKVLRLFAASLDTFLRGATLEPVRVNGFPALLMRVCGKLDGVLTLRLDDGLVSGLYYVRNPEKLSRVR
>NC_013947.1|WP_013015368.1|84066_85125_+|FAD-dependent-oxidoreductase
MKVVVVGAGYAGMMAANKLARKARNAEITVINPRPQFVERVRLHQRIAATTRAARPFSAMLRKGIRSRVGTVDKIGDGTVVLDDGARFDFDHAILAVGSTVRPMPGTVPVGSWDGAEAARRSLAALGEGATVTVIGAGPTGIETASEIASTRPELRVRLIGAAIAHSYSLGARERVLTELERMNVDLVEDSVTEVTDGVVRLESGDRFRSDLSLWAVISGVPQLASRSGLAVNEDGQVIVDAYLRSVSDDRIFAVGDCAAVPGARFSCQCAIPQGGYVGGACARLLRGRELEPFVMRFRGRGVSLGRRDAVVQFTDADDNPKESFAAGATGVALKELATRGAKFGAGTGWGA
>NC_013947.1|WP_013015369.1|85183_85999_+|glycosyltransferase-family-2-protein
MNAVNQPRPSALATLARSTAAPARTAPAVVDQSVIIPVYNESDRLAATLAEVRAHLNGAGGAWELIVVDDGSRDDSAAIAARFAAGEPRIRLLRTPRNRGKGHAVRHGVLASRGRRVLYCDADLATPIGELDRLHAKLDAGFAGAIGSRVGPHADIRQRQPLPRVLLGRLGNRLIRLAAVPGVGDTQCGFKLFDGDKARRAFTLTRVDGWAFDVEVLYLFARGDWPVAEVPVRWSHRAGSKVRMRDYPATLAELLRMRWRHRGAPPRVRQQ
>NC_013947.1|WP_013015370.1|85995_87753_+|glycosyl-transferase
MTATAVLAAAETRSRSRWRPWHARAWVPATYLVASVALYLGLWASPSGRYLIDSGQDQNQWEWFFAVTARSVTELDNPLFTTLQNHPEGVNLMANTTMLGVSVPLTPVTLLLGPGVTWALVLTGSLAATATAWYWLLHRRLGHSRLAAALGGGFCGFAPPVITHAHAHPNFVALFVLPFVVALLLRLWDGERPLRDGAILGLLLAYQIFLGEEVLLLFATGMTIFAIAYAATRPARARAALRPLGTGLGVAAAVSLSLVAFPLYWQFLGPQSYSGLLHGNAGNDLLAFVTFASRSLGGDDRTAGALAWSTEQNSFFGWPLVIMVVTLAAVLWRVPRARALSITVAVAALLSLGSSVKFDGEDTLIPGPWLLLSWLPLYESVLDSRLAMVCVPAIAVLLAMAVDRVRLLFGLPHWQRTPRLLWTGVLLAVLAPIAPTPFTVVDRAPTPTFFTSGMWREYVPDGGTVVPVPIPSPGDTTALQWQLDSDLDFRLPEGYFIGPGQPDRRGIYGAMRRPTSVLLREVRDSGEGRDVTEEQREQAAEDLRHWDAELVVLGPHPAEDALRYTVEDLLGPGHRAGGVWVWKVR

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Crispr_ID: NC_013947_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_3

863393-863506

Orphan

Consensus_repeat	Method
GGCGGGGCTGGGCGCAGGTGGCGGGTCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_3

>merge|NC_013947|3|863393-863506|CRISPRCasFinder
GGCGGGGCTGGGCGCAGGTGGCGGGTCACCAGCTCAGCTTGGGGGCGGGGCTGGGCGCAGGTGGCGGGTCACCAGCTCAGCTTGGCGGCGGGGCTGGGCGCAGGTGGCGGGTCA

>NC_013947|3|3|863393-863506|CRISPRCasFinder
GGCGGGGCTGGGCGCAGGTGGCGGGTCA	CCAGCTCAGCTTGGGGGCGGGGCTGGGCGCAGGTGGCGGGTCACCAGCTCAGCTTGGC
GGCGGGGCTGGGCGCAGGTGGCGGGTCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_052305226.1\|855857_856382_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|376377
NC_013947.1\|WP_013016100.1\|864707_865799_-\|PLP-dependent-cysteine-synthase-family-protein	unknown	unknown	gnl\|CDD\|223110
NC_013947.1\|WP_041624538.1\|854271_854664_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013016088.1\|854673_855828_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
NC_013947.1\|WP_013016107.1\|871108_872182_-\|c-type-cytochrome-biogenesis-protein-CcsB	unknown	unknown	gnl\|CDD\|274447
NC_013947.1\|WP_013016095.1\|859414_860320_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NC_013947.1\|WP_144300724.1\|870172_871099_+\|4-hydroxybenzoate-octaprenyltransferase	unknown	unknown	gnl\|CDD\|183814
NC_013947.1\|WP_013016102.1\|866449_866647_+\|BldC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133390
NC_013947.1\|WP_052304897.1\|860430_862383_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270916
NC_013947.1\|WP_013016090.1\|856416_856704_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|367760
NC_013947.1\|WP_013016097.1\|862365_863205_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_013947.1\|WP_013016093.1\|858155_858551_+\|tautomerase-family-protein	unknown	unknown	gnl\|CDD\|379645
NC_013947.1\|WP_144300391.1\|867447_868701_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224152
NC_013947.1\|WP_013016091.1\|856711_857233_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_013947.1\|WP_013016101.1\|865862_866321_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_013947.1\|WP_013016094.1\|858600_859425_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|372253
NC_013947.1\|WP_041624539.1\|864228_864711_+\|HXXEE-domain-containing-protein	unknown	unknown	gnl\|CDD\|379370
NC_013947.1\|WP_013016105.1\|868709_870167_+\|menaquinone-biosynthesis-decarboxylase	unknown	unknown	gnl\|CDD\|163413
NC_013947.1\|WP_013016098.1\|863511_864135_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013947.1\|WP_013016103.1\|866710_867352_-\|UbiX-family-flavin-prenyltransferase	unknown	unknown	gnl\|CDD\|223241

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_052305226.1\|855857_856382_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	1.71594e-81
NC_013947.1\|WP_013016100.1\|864707_865799_-\|PLP-dependent-cysteine-synthase-family-protein	gnl\|CDD\|223110	COG0031, CysK, Cysteine synthase [Amino acid transport and metabolism].	1.09926e-102
NC_013947.1\|WP_013016088.1\|854673_855828_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	5.13466e-161
NC_013947.1\|WP_013016107.1\|871108_872182_-\|c-type-cytochrome-biogenesis-protein-CcsB	gnl\|CDD\|274447	TIGR03144, cytochrome_c_biogenesis_protein_chloroplast, cytochrome c-type biogenesis protein CcsB. Members of this protein family represent one of two essential proteins of system II for c-type cytochrome biogenesis. Additional proteins tend to be part of the system but can be replaced by chemical reductants such as dithiothreitol. This protein is designated CcsB in Bordetella pertussis and some other bacteria, resC in Bacillus (where there is additional N-terminal sequence), and CcsA in chloroplast. We use the CcsB designation here. Member sequences show regions of strong sequence conservation and variable-length, poorly conserved regions in between; sparsely filled columns were removed from the seed alignment prior to model construction. [Energy metabolism, Electron transport, Protein fate, Protein modification and repair].	7.81732e-78
NC_013947.1\|WP_013016095.1\|859414_860320_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	6.8088e-104
NC_013947.1\|WP_144300724.1\|870172_871099_+\|4-hydroxybenzoate-octaprenyltransferase	gnl\|CDD\|183814	PRK12888, ubiA, 4-hydroxybenzoate octaprenyltransferase.	1.66273e-156
NC_013947.1\|WP_013016102.1\|866449_866647_+\|BldC-family-transcriptional-regulator	gnl\|CDD\|133390	cd04762, HTH_MerR-trunc, Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins. Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.	7.2215e-16
NC_013947.1\|WP_052304897.1\|860430_862383_+\|hypothetical-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.41978e-42
NC_013947.1\|WP_013016090.1\|856416_856704_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	3.78459e-13
NC_013947.1\|WP_013016097.1\|862365_863205_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.29954e-23
NC_013947.1\|WP_013016093.1\|858155_858551_+\|tautomerase-family-protein	gnl\|CDD\|379645	pfam14552, Tautomerase_2, Tautomerase enzyme.	1.37048e-21
NC_013947.1\|WP_144300391.1\|867447_868701_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224152	COG1231, COG1231, Monoamine oxidase [Amino acid transport and metabolism].	4.70231e-57
NC_013947.1\|WP_013016091.1\|856711_857233_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.10012e-18
NC_013947.1\|WP_013016101.1\|865862_866321_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	4.80238e-40
NC_013947.1\|WP_013016094.1\|858600_859425_-\|ABC-transporter-permease	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	6.19057e-05
NC_013947.1\|WP_041624539.1\|864228_864711_+\|HXXEE-domain-containing-protein	gnl\|CDD\|379370	pfam13787, HXXEE, Protein of unknown function with HXXEE motif. This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.	1.2736e-05
NC_013947.1\|WP_013016105.1\|868709_870167_+\|menaquinone-biosynthesis-decarboxylase	gnl\|CDD\|163413	TIGR03701, mena_SCO4490, menaquinone biosynthesis decarboxylase, SCO4490 family. Members of this protein family are putative decarboxylases involved in a late stage of the alternative pathway for menaquinone, via futalosine, as in Streptomyces coelicolor and Helicobacter pylori. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0
NC_013947.1\|WP_013016098.1\|863511_864135_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.5985e-15
NC_013947.1\|WP_013016103.1\|866710_867352_-\|UbiX-family-flavin-prenyltransferase	gnl\|CDD\|223241	COG0163, UbiX family flavin prenyltransferase [Coenzyme transport and metabolism].	2.55207e-70

>NC_013947.1|WP_013016097.1|862365_863205_-|alpha/beta-hydrolase
MREIKTRDGRTLAVEEWGVPGGTPLLYAHGTPVSRLARYPYDEAFTERGIRQITFDRPGYGYSTANPGRRVADVAADMAAIADALELERFGVYGVSGGGPHALAFAAAYPERVSRVAVLACTAPRDAEGLDWTADMYQGNRDSATAAAQGREVLTAHLAAASGPNLKDLLPEAEQAVIAEPAVASMMQAAFAEAFRNGQDGWIDDELALYALPWGFDPADITVPVRLWHGERDTLVPPAHSDWLAARIPDATLVREPDAGHAGHFRATPSTLDWLLGAD
>NC_013947.1|WP_052304897.1|860430_862383_+|hypothetical-protein
MQPLEDGDPERIGRFRLESRLGSGGTFLGLSEGGRTVVVKLLDAGAAAAPGLRERLSAMRGVGGFALPQLIDVDLDASPPWLATAYVPGPSLSAVVDERGPLPETEVAALGAALAEALDAMHQYGLAHGDLKPGNVIMASDGPRLVDVGVAVADASPAADVFALGRVLTFAATATDPVAAEAPWPDGIDGELREVLAACLARDPRERPGAVEVLERLANHRATGAESLSVTSLTSTESRPTPRSGRRLLGRGGPGTGGLRLRRRTILMGGAAILAATAVPAALAYWPSPRGQRLTGMAVTSVAFSPTGDIVAGGGGNENRPEGDGRLWNPDTGRELGVMDGRGISGVAFSADGGVLATSGPRGARIRDPDTGETIAMFDVSARENVNEEVWAVALSADAKRLAVGGRTLDEIETVCVVWNVSGTERIASLTTTDIHCVRSVALSPDGRCAALAGVARGSGTANKANYAMENGAGCWLWGLESGNAWGLRKGELRVVYSGGYANAVAFGPDGDTLAVASRDSGCRLWTPESERAAVTYTTDPVSGIAFSPDGAVLATAGTGVAFGMDRFGRFEVEGGPAEAADGPGKQVSGAGIRLWNTTSGDHLDTVTEDYATSVAFGPDGRTILGSGGDGGTDTATGCWLWPIGLVGAQ
>NC_013947.1|WP_013016095.1|859414_860320_-|ATP-binding-cassette-domain-containing-protein
MNLPVETRKLTKKYGPITAVDALDLTVRPGEVYGFLGPNGAGKTTTLRMLLGLIKASSGTATVLGRKPGTADHLSRVGALIEGPSFYPYLSGRSNLRVMAKYAGVPDSRVSEVLELVDLAQRGKDRYSTYSLGMKQRLGVAAALLKEPQLLILDEPTNGLDPQGMADMRTLIRGLGSAGCTVLLSSHLLGEVQQICDRVGIVSGGRLITESTVADLRAAQHVRVTATPLDKAASVARELLGVEAVRVVDNHLELAVEADQTPWLNAELVKADVAVSELRSHERDLEDIFFELTGEELSHVG
>NC_013947.1|WP_013016094.1|858600_859425_-|ABC-transporter-permease
MWASTKAELHKMVRRGANWFMLAIALVLGLTFAYLVPYAGYVGGDSDIPSADRGLEALLPAEFVGNSIGGLPFFTGAISLILGALAIGNEYGWGTWKTVLTQGPSRLTVFSGKLAALTVANLVLVASGIATSAAASAIIASVEDQAMDWPAFADVALGLGGGWLIAMMWTMMGVTLAVTTRGVAVAVGIGLVWMLAVQNLLVSIAAPLIDWIADAQEWLPGPVAGSLVESLGANPNTPGVAELVSDGHALTVICGYLLLFGVLSGVLLRRRDVV
>NC_013947.1|WP_013016093.1|858155_858551_+|tautomerase-family-protein
MPTTLVEVRRQYSQAEEVGIIDAVHDALVSAFEIPVEDRNVRLIVHEPHRFACSPRHTLPEFYTLVSVDCFAGRSVRAKRKLYTEIVDRLAPFGIPRDHVTINLRESPTENWGYAGGKAACDMDLGFDVNV
>NC_013947.1|WP_013016091.1|856711_857233_-|GNAT-family-N-acetyltransferase
MTEVSLSDGVIILTPFHRCDAAAHLAGEDADMERWLSGGPGSPERLAAYFQHVQRQWTIAGPLRHFGIHLEAPEPILVGTIDVQFEQPELTEGQANIAYGLYPRWRGRGLVSRAVELVCSYAAAEGANEAIIRTATDNPRSAAVARRCGFEYTGRHPDSDGKPHDWFSRGLRP
>NC_013947.1|WP_013016090.1|856416_856704_+|antibiotic-biosynthesis-monooxygenase
MVIVAGQLTVAPSQLESYLASCVSVVEQARRAPGCLDFTIAADPLDPGRVNVYERWESREAVEAFRGSGPSDEQAATILGASVAEYDIAATRSLT
>NC_013947.1|WP_052305226.1|855857_856382_+|5-(carboxyamino)imidazole-ribonucleotide-mutase
MGSDSDWPTMKAAVEMLDHFGVAHEVRVVSAHRTPHAMLTYADEAAARGLRVIIAGAGGAAHLPGMVASATPLPVIGVPVPLKHLDGMDSLLSIVQMPGGIPVATVSVAGAKNAGLLAVRVLGVADPALRLAMSDYQRELVDMVADKNTRLQETVANDSAAKPGGGFGFVPGNG
>NC_013947.1|WP_013016088.1|854673_855828_+|5-(carboxyamino)imidazole-ribonucleotide-synthase
MDSRTQLPVVGMVGGGQLARMTHQAAISLGQSLRVLAASADDGAAIVSTDVHVGSHTDVEALRGFAKECDVLTFDHEHVPGDLLRTLRSEGVVVRPAPEALRYAQDKQAMREHLGGLGLPVPRWAPIDSVAALADFGVPCVVKTATGGYDGKGVFYVDAPEQITELLDAGAVLIAEERVRLRRELAALVAGSPGGELASYPIVETVQRDGICTEVIAPAPGLSEVLAEQARELARRVATELGVTGLLAVELFETDDGLVVNELAMRPHNSGHWTIEGARTSQFEQHLRAVLDYPLGETAPTAPVTVMANVLGGAPGGSRLDERLQSMLADDPGARVHLYGKQVRPGRKIGHVTVLGDDVETVRRRARRAAAWLRDGDPEAGEEA
>NC_013947.1|WP_041624538.1|854271_854664_+|hypothetical-protein
MAASGDALTLLRERLDCLYAAGDADGYSLVVVALAPEAGGFDRLAMRLSYARILSEATGVPAAMTGAALAVALINRDRNLSATLAMLRMRLGRATTTGRPPRVWLERLPAELPMAYELLDELSELSTSQH
>NC_013947.1|WP_013016098.1|863511_864135_-|TetR/AcrR-family-transcriptional-regulator
MGAKSGRFQPRKNPSQHRARLTRDRILAAAAQVFASHGYAAGTTDRIAAAARISIGSLYQYFPNKDAVLLALSQAHLEAATDAIRAVLAEAGEDWLDGVIAAVIDGHAANPRLHKVLFDEAPRTPELLDRLRAAESAIAATIAERLRGDGRFDVEDPDEAADLVVATVESLTHHFVARDPDGFDAATTQQRISELLTRHLRPAPPPS
>NC_013947.1|WP_041624539.1|864228_864711_+|HXXEE-domain-containing-protein
MTAPRDHGWIPRADRRWLLLPYAVFIVHTTEEMPGFAAWATRHFAHKTTEIFALSHIPLILLVLAAGWLAARPGTHRVAVLWTAAFAWQFVVNAAFHLTTAAIYGEYSPGMVTAATVAIPAAGYFFVRLRADRLLRRGELVTALLLGTAIAALAIGVLFV
>NC_013947.1|WP_013016100.1|864707_865799_-|PLP-dependent-cysteine-synthase-family-protein
MDSLDRCCDKTRAWVNEAIAAVAADANRSADTHLLPFPLFGDFGVDLYLKDESVHPTGSLKHRLARSLFLYALCNGWITEGTPIIEASSGSTAVSEAYFARMLGLPFIAVMPASTSREKISLIEFTGGSCHLVDDPTQVVATARALAAQQGGHYMDQFTYAERATDWRGNNNIAESIYQQMAAEPHPIPAWVVVGAGTGGTSATIGRYIRYQRHSTKLCVVDPENSAFFSGWRDNDESAYVCGGSRIEGIGRPHVEPSFLPSVVDRMVKVPDAASIAIAREASKLLGRKVGGSTGTNLYAAFALIAEMRQRGETGSVVTLLCDSGDRYVHSYFDDAWVAGQGLDLRPHTETVTEFFASGRWTV
>NC_013947.1|WP_013016101.1|865862_866321_-|Lrp/AsnC-family-transcriptional-regulator
MDDIDRRIVQLLQENARRSYAEMARQVGLTSPSVQERVAKLERNGVITAYRAEVNPDAVGLGITALIGIVTTAGAEYSDVAEAIEEIHEVESCYFMAGQESYLLKVRVGEMAELEHLVNRLNRLPGVGGTRTTVALSTKWEARPHTRLDGEP
>NC_013947.1|WP_013016102.1|866449_866647_+|BldC-family-transcriptional-regulator
MDNDRLLTPGEVAALFRVDPKTVTRWAAAGRIGSIRTPGGHRRFRESEVRALLQGELGDSSALDH
>NC_013947.1|WP_013016103.1|866710_867352_-|UbiX-family-flavin-prenyltransferase
MRCPWVVGVSGASGTPYARAVMSGLLDAGESVDLVVSRAARLTILDETGESFRDAHWKDDLARWLGREVGEADIAYWPAGDLAAGPSSGSYRVKGMVVVPASTAACAGIAIGLSKDLLQRAADVNLKERRPVVVVPRETPVSRSHLQHLLSLHDAGAVVLPASPGFYAGATDVQQLVDFVAGRVLDAIEVPHTLYTRWRGELGGGLGAPPPGR
>NC_013947.1|WP_144300391.1|867447_868701_+|FAD-dependent-oxidoreductase
MDHARTHTYPESGVPDPDAAPPPPAEILAVPTDGLGAGPSEPKRVIVIGAGIAGLAAAFELARAGHQPIVLEARDRVGGRIHTIRDFAPGLYAEAGATRIPHTHALTLRYCELFHLKLRPFVMGNPRALAHRDGRTVTMAEAERGDGRDWAQTAAGDAREIEGGTDRLVRAFFHKVSRHVRMGAEVLAIEQDEEVVSVHFRTHAGRFTVHGDHAVCTLPLPVMSNVDINLSPDKRRAVREVHYNPATAVLLQVRHRFWEHPKYDIVGGTTVTDLSIRRIVYPSYSDPATPRGILLASYTWGPDALRWASMDPDTRVERAIADVARIHPEIVEEFELGVSEDWLNDRHAAGALAQFEPGQLTRLYPHLVAPEGRIHFAGEHCSRHHGWIQGALESALRVAGEIHRAPVAASARAGRSG
>NC_013947.1|WP_013016105.1|868709_870167_+|menaquinone-biosynthesis-decarboxylase
MAAKFPYGDLGEFLAALEADGDLKRVTAPVDTNLEISEITQRVVREGGPALLFENPTRGDMPIAINLFGTPQRMAKALGVNDLDEVGARIGALVKPELPVGFAGIREGLGKLMQLKSLPPKKVRSAPCQQVVYKGKDVDLNRLPGLQTWPGDGGIFHNFGLTHTKHPETGKRNLGLYRLQQHDSKTLGMHWQIHKDSTAHHAVAERRGERLPVAVAIGADPVVNYAAGAPLPGDIDEYLFAGFLRGERVEMVDCLTVPLQVPANAQIILEGYVEPGERLPEGPFGDHTGFYTPIEPFPVLHIECMTTRRDPVYHSIITSKPPQEDYGLGKATERIFLPLLKLLIPDIVDYNMPEPGVFHNCVIVSIRKRYPKHAQKIMNAIWGAHLLSLAKLIVVVDEDCDVHDLNEVAWRAFGNVDYSRDLVVTEGPVDHLDHASYQQFWGGKAGIDATAKLPTEGYTRGWPHEATMPSAIKATVDSRWAEYGL
>NC_013947.1|WP_144300724.1|870172_871099_+|4-hydroxybenzoate-octaprenyltransferase
MRAFLRLVVIEHSVFALPFAYLSALTAMYLYPRSCPPGSGSCGWFAYAPANSGGLSWIQWDVLLLVTVAMVAGRTFAMAANRIIDRHVDARNPRTANRELVTGAVSLRTAYVGSAVSLVVFFGAAAMLNPLCLILSPLAVAPLIVYPYGKRFTDFPHAILALAQAVAPVGAWLAVTGTFAGSLPAIVLGIAVGLWIGGFDLIYACQDAEVDRKIGVRSFPSRFGVAAALHTSSAVHVVTFAGFVWFGLLVGFGALAWIGLAITAVTFVYEHAIVSPNDLSKVNRSFFMANGFVGIVLFGFTLADLLLR
>NC_013947.1|WP_013016107.1|871108_872182_-|c-type-cytochrome-biogenesis-protein-CcsB
MPSSSGLADASNAAFVITIVLYAVAMFGYAVEYAFGRREAKAAEHRQLAAVGAGGEFTVPGEYADKSADGAFESHLSIELDEDDSDEDEDDSRPQQPGVTSKQALAAGRIGFVAMVLAAVAHTASLGLRAAAVGRWPWGNMFEFIVAVALVGVIVWIVLVGRGTVSRRLGLFTMLAVVLLLGSATRVYTDAAPLVPALDSYWIAIHVFAAIIATGVFLVGFVAAVLHLLKRGYDRKTAAGQPIRFPFTIAQRLPLAEKLEKLTWRMHVLAFPLWTFGVIAGAIWAREAWSRYWGWDPKEVWAFIAWVVYAAYLHARNTGSTGRTLAPWIVIIGWAVMLFNLFGVNLVVNSLHSYAGV

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Crispr_ID: NC_013947_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_4

1128003-1128106

Orphan

Consensus_repeat	Method
GTGAGCGAGCGAAGCGAGCGAGCCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_4

>merge|NC_013947|4|1128003-1128106|CRISPRCasFinder
GTGAGCGAGCGAAGCGAGCGAGCCAGGAAGCAGAGCAGCCCCGCGAACGCGGCCACCGAGCGCAGCGAGGTGGGCGTTGTGAGCGAGCGAAGCGAGCGAGCCAG

>NC_013947|4|4|1128003-1128106|CRISPRCasFinder
GTGAGCGAGCGAAGCGAGCGAGCCAG	GAAGCAGAGCAGCCCCGCGAACGCGGCCACCGAGCGCAGCGAGGTGGGCGTT
GTGAGCGAGCGAAGCGAGCGAGCCAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013016343.1\|1126655_1127111_+\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100006
NC_013947.1\|WP_144300401.1\|1131950_1133690_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013947.1\|WP_013016340.1\|1124920_1125889_-\|ArsA-family-ATPase	unknown	unknown	gnl\|CDD\|223082
NC_013947.1\|WP_041625623.1\|1119892_1120453_+\|response-regulator	unknown	unknown	gnl\|CDD\|381147
NC_013947.1\|WP_013016348.1\|1134688_1135156_+\|DUF4282-domain-containing-protein	unknown	unknown	gnl\|CDD\|379475
NC_013947.1\|WP_013016338.1\|1123329_1123641_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NC_013947.1\|WP_083787325.1\|1127301_1127994_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293836
NC_013947.1\|WP_052305235.1\|1137598_1138288_-\|endonuclease-III	unknown	unknown	gnl\|CDD\|223255
NC_013947.1\|WP_052305234.1\|1135152_1136331_-\|MarP-family-serine-protease	unknown	unknown	gnl\|CDD\|367140
NC_013947.1\|WP_013016354.1\|1140594_1140957_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013016341.1\|1125899_1126415_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013016353.1\|1138487_1140602_+\|SseB-family-protein	unknown	unknown	gnl\|CDD\|223021
NC_013947.1\|WP_041624561.1\|1120535_1120901_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_013947.1\|WP_013016347.1\|1133772_1134450_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_013947.1\|WP_013016351.1\|1137038_1137602_-\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NC_013947.1\|WP_013016345.1\|1128157_1131838_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|143636
NC_013947.1\|WP_086013309.1\|1126497_1126659_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379366
NC_013947.1\|WP_013016339.1\|1123689_1124811_-\|ArsA-family-ATPase	unknown	unknown	gnl\|CDD\|223082
NC_013947.1\|WP_013016337.1\|1120911_1123029_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NC_013947.1\|WP_013016350.1\|1136400_1137042_-\|CoA-pyrophosphatase	unknown	unknown	gnl\|CDD\|239518

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013016343.1\|1126655_1127111_+\|RidA-family-protein	gnl\|CDD\|100006	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	2.7671e-63
NC_013947.1\|WP_144300401.1\|1131950_1133690_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.4974e-65
NC_013947.1\|WP_013016340.1\|1124920_1125889_-\|ArsA-family-ATPase	gnl\|CDD\|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	1.34721e-30
NC_013947.1\|WP_041625623.1\|1119892_1120453_+\|response-regulator	gnl\|CDD\|381147	cd19920, REC_PA4781-like, phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains. Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.03313e-34
NC_013947.1\|WP_013016348.1\|1134688_1135156_+\|DUF4282-domain-containing-protein	gnl\|CDD\|379475	pfam14110, DUF4282, Domain of unknown function (DUF4282). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 93 and 155 amino acids in length. There is a single completely conserved residue E that may be functionally important.	9.44498e-24
NC_013947.1\|WP_013016338.1\|1123329_1123641_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.57854e-23
NC_013947.1\|WP_083787325.1\|1127301_1127994_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293836	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	6.52592e-58
NC_013947.1\|WP_052305234.1\|1135152_1136331_-\|MarP-family-serine-protease	gnl\|CDD\|367140	pfam02674, Colicin_V, Colicin V production protein. Colicin V production protein is required in E. Coli for colicin V production from plasmid pColV-K30. This protein is coded for in the purF operon.	3.83781e-22
NC_013947.1\|WP_052305235.1\|1137598_1138288_-\|endonuclease-III	gnl\|CDD\|223255	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair].	9.31263e-102
NC_013947.1\|WP_013016353.1\|1138487_1140602_+\|SseB-family-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	6.4186e-08
NC_013947.1\|WP_041624561.1\|1120535_1120901_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.65069e-24
NC_013947.1\|WP_013016347.1\|1133772_1134450_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	7.77798e-54
NC_013947.1\|WP_013016351.1\|1137038_1137602_-\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	5.38421e-33
NC_013947.1\|WP_013016345.1\|1128157_1131838_+\|AAA-family-ATPase	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	7.5546e-52
NC_013947.1\|WP_086013309.1\|1126497_1126659_+\|hypothetical-protein	gnl\|CDD\|379366	pfam13783, DUF4177, Domain of unknown function (DUF4177).	0.00541812
NC_013947.1\|WP_013016339.1\|1123689_1124811_-\|ArsA-family-ATPase	gnl\|CDD\|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	2.05133e-40
NC_013947.1\|WP_013016337.1\|1120911_1123029_-\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	2.82823e-123
NC_013947.1\|WP_013016350.1\|1136400_1137042_-\|CoA-pyrophosphatase	gnl\|CDD\|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	5.85261e-54

>NC_013947.1|WP_083787325.1|1127301_1127994_+|MBL-fold-metallo-hydrolase
MTLDGTNTWLIAANAGHDALVVDPGPAIEEHLAAVAASGPIRGVLLTHHHPDHAEGLERFRELTGAGVVNPGPGQRLVHGDLTITTIATPGHTADSVSFHVGGASPAVFTGDTILGHGSTAVLWPDGNLGHYLDSLKRLRGLGPIPVLPGHGPVRRDAAAAATEYETHRQARLDQVRAALAAGAASPREVVEVVYADVDKSLWPAAEATVRAQLAYLEERDAEHIRPGGS
>NC_013947.1|WP_013016343.1|1126655_1127111_+|RidA-family-protein
MSDHLARLTELGLTLPPVVPPVAAYQPAIRSGAHVYVSGQVPMVDGKLPEVGPVDTLELERAQELARICALNGLAAIDALVGLNAVVRIVKVTGYVAASDVYTDHPKVINGASELLGEVFGEAGRHARAAVGVSSLPMGAPVEVDMIAEVS
>NC_013947.1|WP_086013309.1|1126497_1126659_+|hypothetical-protein
MQKWEYATVPLLVHATKQILDTWGEDGWELVAVVPGPNAENTVAYLKRPKEQA
>NC_013947.1|WP_013016341.1|1125899_1126415_-|hypothetical-protein
MSNNTEPHAEAGPPADETDENTNPPARTKLVAATILAVAALFGGAVVFGGLWLTGQWDGPSADDPAESVDGFLTALFTEHDAKDAASYTCASQSGDLGKVVDELDDAAAAAQFSWSKVTTVETDGSSAVVTAKVTHDVSGESAVWTFALVTGDPDDAWRVCGVITDDKSKS
>NC_013947.1|WP_013016340.1|1124920_1125889_-|ArsA-family-ATPase
MPPEPAAERRTSPHVHVVTGKGGVGKTTVAAALAMALAPPGGRTLLVEVEGRQSIAPLFDTAPLPYAERHVATAPGGGEVFALAVDAEDALYDYLSMFYKLGRAGRALRKIGAIDFATTIAPGLRDILLTGKVKEAATRTDRGRRVYDAVVLDAPPTGRISRFLNVTVEASKLAKVGPIRNHSDGVAKLLHSPKKTAVHVVTRLEEMPVQETLDAVAELTALKLPVGHILVNAVSPPLLQGVRVTKAGLKRDLVTAGLPHDAGTVDGLVAEARDHQRRLAVQSELRGELTALDHPVVELPLQADGIDLSGLYTLAELLRSET
>NC_013947.1|WP_013016339.1|1123689_1124811_-|ArsA-family-ATPase
MEPPELDADALIANPDTKVVVCCGSGGVGKTTTAAALALRAAEVHGRQTVVLTIDPARRLAQSLGLAELDNTPRKVEKVTGGGLDAMMLDMKRTFDEVVLAHTTPEQAAEIFGNPFYQAMSGTFAGTQEYMAMEKLAQLRAKDQWDLIVVDTPPSRSALDFLDAPARLARFLDGRMLRILTASSRGGHSVFSLMTSSMSFFTRTINKILGGRMLTDIATFAASLDSTFGGFRTRAEATYRALQDPQTAFLVVAACEPDAIREAIYFTRRLTEERMPLAGLVLNRSHAVTAEGLSAERALGAAEGLEADGVDSATADTLRVHARLVTTVATETRIAARYTTACPSVPRTRVPAFPADVHDLDDLRAVGTAMTNT
>NC_013947.1|WP_013016338.1|1123329_1123641_+|WhiB-family-transcriptional-regulator
MTMMVDWTSAAACREGDPDALFVQGAEQNVAKKVCKGCRVRMECLADALDNQVEFGVWGGMTERERRALLRKHPDVTSWRKVFEAALEKEAADRIGRVLEPTG
>NC_013947.1|WP_013016337.1|1120911_1123029_-|penicillin-binding-protein
MCGLFAGVVVAASAFPSLAVVGLTAKASSDGFEGLPTELQDPPAPQTSWLYANDGETLITSFYDESRKEVDLDDIAPVMQKAIIAAEDNRFYEHNGVDLVGVIRAGVANQGGGEVSQGASTLTMQYVRQALTYNAKTNQDVLEATEDTPQRKLREMRYAAAVEKQYSKKEILERYLNLVFLGNQSYGVYAASQAYFSKDPSELELQEAAMLAALPKAPGTIDPSLGEKENKKAKERRNYVLDRMVKTKAISKKQADKAKKTDLDLKPSNQPSDCTAVPQDRKDWGFFCDFFKDWWMNNPQFGSTKDERLNNLKTGGYVIKTTLDPDLQEKAQKEVTKRQKKDSSWALGDVTLDPKTGSVKSMAINRDFSLDISKNGPNSGGSGKGTYPATTVPLLSGGSGKAGAGFQAGSTFKMFTMLAALKQGKSLKTTYDNPKGDYPSKIYGVGYNPTESSCGKRNADGQYAWCPGNDNPKWMAGKADMYRGFGRSVNTYFVQLLEDVGAENAVDMAKSLGIDLRGKGDQENDENPRKKHLWGSFTLGVSDTTVMDVAEAYGTVANDGIHCDPLPVKSMTDSKGNKVDAKPECERVISSDVARAAADAARCPVGDQAQSGKCQDGTFRDGHKIVGRPMAGKTGTTQSNQASWFVGMTPNIVSAGFIADPDVRSKSLPQSYHNLPHEAVSHTMKAALEGEPVENFKKPTGKLVG
>NC_013947.1|WP_041624561.1|1120535_1120901_+|STAS-domain-containing-protein
MTRPELEISVRHEADKAVVTLAGEIDIGTAPRLTAAVEGALESNPVRVELDMSGVTFCDSQGLGTLVVLNRAATRSRSVLVLAELTDFLDRLLHVTGLHQAFTIQNDDAADADGTGDAATS
>NC_013947.1|WP_041625623.1|1119892_1120453_+|response-regulator
MARQARILMVDDRRENLTALQAILQGLAVSTEAVTSGEGALKKLLTGEFAVILLDAQMPGMDGFETARHIKQRERTRHTPIIFLTAADRDSHMAFRGYAAGAVDYITKPFDPWALRAKVGVFVDLWDRKEKLKAEAARLRIAETERDRLRSIIEDAARTLREGNGDRPPENVAKALKTLAQAEVDG
>NC_013947.1|WP_013016345.1|1128157_1131838_+|AAA-family-ATPase
MSCPFCGIAAVVPGARYCHNCGGPLSPVASLPVTERRVVTVLFCDLSDFTAWSEGQDPERVGAVTDRVLAECAQAVTEYGGHVDKLTGDGLMAVFGAPVAHDDDAERAVRAAQRMRRAVRKLLKTESGGGVPMGLRVGLRTGLVVAGVQASVEYTVVGDTVNTAARLADVAEVGTVYASVETVRATKHVAAWRHLNPVRLKGKRDPVEVYELLGLHDEPGIRAGLGDRAPFVGRAPEMGRVAGRLDAAINRGEPISLVMTGEPGIGKTRMALESARLATSRGARVLSVRAAAYGQGYRLGPLADLIRKAIGLSIGDDRATAERQLRKIVERHNASDHHDSCVLNVDLLLAVLGYGPAPRTQGRPGAEETAPGSDAISAAAADLFNLLARETPLVLILDDLHAATVQALDFLGATVAALSGPILVIMFGRPSLVRTAGVLTRVSEAEAYTLTPLRGSDAARLLSAFCDNGKVDPEDESRLLATAQGNPYYLSELVTLLTEHGMLTEHNGVWELAPGSLTGRLLSADLAKVLTARIDALPPESRQLLREASVIGDVIPAAALEVLDSETTGDLDKALEALLSRRMLRRRTHGGYRFVTPLMREAAYAGLGKADLAGRHARLARWASETTALDGGQADQFAITHARRSVALSQAMTLSASPDVVDIGVAACGRAAGRAMDAAEPENALSLLEQSADLKPLSPADQLVRARALLRLGRTDDTLDALTDVATQVGLAVPLDAIPCDDPVAALTGPLADVGAATADTTAAERSLAAAEAQAVGQPSAEAADRPLAEAARSGSLGTERSLADAVGQPSAEARAAAQLSVAEGGDPTGQSDTAVKFPVEAARTLLVAGRAYRAEGEPDKAARVWSRAFTVARSAGLSTEQCDALCRLGMFDYLGGRMRRAEERFTTALRVATEGGDRRAQAWALQHLAWVLTSVGDFTAADDALGRALRLFALQKDRLGRAWVRSSAAFTRLLAGRLREAQRLAEAFRPFGEKVGDAWAVGLLRGISAYAAADLGELAEADTLARKAFREFDRIADDWGRGFTLVVRGAIARDLGELEHAMELVDEAELYATKAAHPLLTGMARVLRGYCLLGLGDFAAAEACARESLSLARPHDVLEPVKVGPLALLAESRAAQGDTDGALRWLAEIAAHADDPALLYSRRRAVARYAQLLWRAGRAEEARHWALRAQDAPGEDANSERLVRQVIDETGASQGSSETTLAVST
>NC_013947.1|WP_144300401.1|1131950_1133690_+|protein-kinase
MSMMAPHGQTWPSETDFPDLAEVSVIARGAHATVYGAFQISAGREVALKIDNRVLAPDSDERRRFQQEARAVGRLSEHPGIIDTYIAGFTSQGHPYMVTELCQGSYADKLAKDGALTPEEVQRIGVRIADALAEAHEHRVLHRDIKPANLLIDRSGNPVLADFGVASLMDSRVGQPVVRAAMTPAYAPLETFHLRPSGEPGDVYSLAATLYALLSGRPPRFPADDRDFTIDDVIGLFTEPIGDVPGVSQTLLGMLRAAMTNNPEGRPSAMQFRDMLDSVPIAAATAAIPVATRTAPVHPALAAPPAPRRPEWTEPVTANVEAIQDRRPSPSPTPSPSPSPMPPPSPGPRPRPAWGIDRKPPAGPQGPPGPPGPPNNLPVPASRGKELELSTRRERRIAARGGKETSGIGQLILVGAIAVTIIVAGAVFAVWAFTGGEESSGDDTTADAVNCDVEKFNLSCVEPALCFNGALNDSKDFAAAEEISCKKEHQWEAYAKGELPKDVETPTIAAVSEQKIVKDTCLNEGSKGPLTSIKGVGASKWDSKVLPPTKKDFDAGSTTFYCVVQPKDGKPTTGSAFSE
>NC_013947.1|WP_013016347.1|1133772_1134450_-|Crp/Fnr-family-transcriptional-regulator
MDETLARAGLFQGVDPEAVEALSKALEYVDVKKGNTIFTESEPGDSLYIVLSGKVKLGRRSADGRQNLIAVMGPSDMLGELSLFDPGPRTATATALTDLKLAKLGKGALRPWLTDRPEIAEQLLRVIARRLRRTNDALADLIFTDVPGRVAKSLLQMASRFGTRDGGVLRVTHDLTQEELAQLVGASRETVNKALADFAGRGWLRLDGKSVIILDPERLARRARV
>NC_013947.1|WP_013016348.1|1134688_1135156_+|DUF4282-domain-containing-protein
MTYPQDPQQQPEQQGGYPQGHTEQPSGHYQQQPDPSHYPPPTGAYQSQPIGGTGKNFFASLFDFSFRSFVTPQVIQIYYVVALVVLGIGVVFGLISAVITIAEFDAFLGLVQLILVPIFGFVYLLLVRMGLELVSNFFRIGEDVKAMREKSDRTV
>NC_013947.1|WP_052305234.1|1135152_1136331_-|MarP-family-serine-protease
MVDIVIVLLALLFAINGYRQGFIIGALGFAGFFGGALIGVQIAPLLVEVSEAPAARVLIALLVVFGIAMLGQWGGSALGVRLRKRVKNDNAKRFDEFGGALVSMVAVLLVAWVVAAPLASSGMPGLAAAVRNSAIVRTIDENMPGPAQNVYNALRSAVNTNGFPEVFSGLDPSDSPPVDPPDPELANSKVVRDAEASVLRVSGDAPQCDRHIEGSSFVYDADRDLVLTNAHVVAGTESVSVAGADGDVEARVVVFDDRRDLAVLYAPGLNAPELDTLDEAAESGADTIVLGYPQGGPYTATASRVREHREVTGPDIYDSGEVTREVYSLRSQVRSGNSGGPLISADGDVYGVIFAAAVDDPDTGYAVTMDEARPIMEEGQTTTESVSTKGCT
>NC_013947.1|WP_013016350.1|1136400_1137042_-|CoA-pyrophosphatase
MTTPRPLTDVELPDWWHPLAEKAASVDGRDITRYLPTEGQGRPAGILILLGADENGPNVILTQRAATLRQHAGQPSFPGGVADPEDASIVDTALREANEEIGLDPDSVTVVTTLPELWLNVTDHRVTPVLAWWHAPHPIAVVDPAEVASISKLPVRDLVDPANRVRYRHSSGYVGPAFEIDGMLVWGFTAGVLSAVLRLAGWERPWEPGRLTT
>NC_013947.1|WP_013016351.1|1137038_1137602_-|TlpA-family-protein-disulfide-reductase
MRLRTLLLGFTVAALTASCSSGGQTADASQDVDWDVPCDESDIGTAAEDFKDFTLECLSNGKDHALGVLDERPTVITLWATWCGPCRKEAPEFRKFHEEYGDQVNLIGVDTQDDRSSGLAFAADAGWRFPSVSDPKGSVMRARGITALPATFLIDEKGTTVATYNDPGLTFEKLEKAALKHFEVERS
>NC_013947.1|WP_052305235.1|1137598_1138288_-|endonuclease-III
MARMLAELHPDAHCELDYADPFQLAVATILSAQCTDVRVNLTTPALFARYPDPAAMAAADRGELEELIRPTGFFRNKTNSLLGLSAALLSDHGGEVPGTMAELVKLPGIGRKTANVILGNAFGVPGITVDTHLARLVHRFGWTTATDPVKIEHAVGELIPKNDWTMFSHRIIFHGRRVCFARKPACGACGLAKLCPSYGSGPVDPDAAAKLLKGPRVAELAAAAERVNT
>NC_013947.1|WP_013016353.1|1138487_1140602_+|SseB-family-protein
MTSMWVPANDIEQHMREALRAGNQEEYFRLLARTDLLLPFAEDTSPSSNGTGSWATWATEDRTHVLVFTSPEAMRACLHAHAGAFRTVSFTALADAWPDSDWWLAVDPGTPIEGYLPAWFVRQVASGDTHLPDDQAPHSQPPMYAANDYPPPRTDYPQSAPPSQFGQFEAAPPPPQFGQFEASPFQQAPPPDPGPRYGETAPSAPSAGPGGLPRREPAAASPAPEPFSQQPADPYDAGLPQRDAYGQPSEAFNSGLPQRDSYPPAEAPPVQDPPSGTYDSPMSSAMPRREPMDSGFGQQPEPEQPAWEPAPRPEEPAWQAQQTQQPASDGYSAASRLPVPVSTALPEWPSEDAVEDELALAASTGDTKAYLSVLLRAWAYLPVAEDCPPSARPGDPEFRWHTDLIDGAYTITAFTSLSRLIARYGDRPHINTTFGRLTAQWPGLEYSLYVNPSTEVGANVPGPQVTTLVTWARTQGLLQPALDMDALGAPRSPASNHGSAQTQAPPPPQAQAPEPAAATPAPTAPELMQKVLPHQQVAMTLERGYDRVAGFVHRYNEVADLNTPEQLYNALGLLRDGVDFSPTDESVHVIRWVGHRGDLYRIAYGGNDPATAERNGGWIVEPPPFSGDGYAPSVEGRRIVEYKVDSVRLPHGATMTRVSADGRSEDIAVYDSDRREWIRADIEAAASSWDISPAGDFRQEQQHA
>NC_013947.1|WP_013016354.1|1140594_1140957_+|hypothetical-protein
MRDGYVARWRGIDYDASPDGAHVRLYSPQPGDGFVEVADGRFRRGVLINEIEDFHYVRTLCTWRGEPFIVLGEFGAWLRLEYCGGNAEVARHLGLETYDVGVYQIWVPRGEAEDVREVRV

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Crispr_ID: NC_013947_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_5

2268405-2268517

Orphan

Consensus_repeat	Method
CCGGTCATCGGTACCCGGCCCGGTCCGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_5

>merge|NC_013947|5|2268405-2268517|CRISPRCasFinder
CCGGTCATCGGTACCCGGCCCGGTCCGGGTCTGGTGCCGTCGGTCAACCGTCCGGTGCCGCCGAATCCGAACGGGACGGTGCGTCCGGTCATCGGTACCCGGCCCGGTCCGGG

>NC_013947|5|5|2268405-2268517|CRISPRCasFinder
CCGGTCATCGGTACCCGGCCCGGTCCGGG	TCTGGTGCCGTCGGTCAACCGTCCGGTGCCGCCGAATCCGAACGGGACGGTGCGT
CCGGTCATCGGTACCCGGCCCGGTCCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013017408.1\|2273156_2274629_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_013947.1\|WP_013017404.1\|2269780_2270218_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013017396.1\|2260397_2261042_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013017411.1\|2276116_2276401_+\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|376329
NC_013947.1\|WP_013017398.1\|2262643_2264452_+\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NC_013947.1\|WP_013017392.1\|2254141_2254768_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380018
NC_013947.1\|WP_013017410.1\|2275064_2276105_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176197
NC_013947.1\|WP_041625899.1\|2257970_2260370_+\|TraM-recognition-domain-containing-protein	unknown	unknown	gnl\|CDD\|274858
NC_013947.1\|WP_013017394.1\|2256087_2257719_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|235704
NC_013947.1\|WP_013017403.1\|2269235_2269784_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013017397.1\|2261082_2262582_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013947.1\|WP_169313871.1\|2265409_2266579_-\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|180883
NC_013947.1\|WP_013017407.1\|2272162_2273104_+\|1-phosphofructokinase	unknown	unknown	gnl\|CDD\|274804
NC_013947.1\|WP_013017401.1\|2266929_2267373_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013017406.1\|2271404_2272166_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_013947.1\|WP_013017399.1\|2264465_2265413_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|227339
NC_013947.1\|WP_013017405.1\|2270210_2271305_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013017409.1\|2274621_2275068_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_013947.1\|WP_013017412.1\|2276588_2278205_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NC_013947.1\|WP_052304970.1\|2255137_2256091_+\|aspartyl/asparaginyl-beta-hydroxylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|377460

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013017408.1\|2273156_2274629_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_013947.1\|WP_013017409.1\|2274621_2275068_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	3.32878e-44
NC_013947.1\|WP_013017411.1\|2276116_2276401_+\|HPr-family-phosphocarrier-protein	gnl\|CDD\|376329	pfam00381, PTS-HPr, PTS HPr component phosphorylation site.	8.54251e-23
NC_013947.1\|WP_013017392.1\|2254141_2254768_+\|hypothetical-protein	gnl\|CDD\|380018	pfam17784, Sulfotransfer_4, Sulfotransferase domain. This family of proteins are distantly related to sulfotransferase enzymes. This protein in S. mansonii has been shown to be involved in resistance to oxamniquine and to have sulfotransferase activity.	3.29347e-63
NC_013947.1\|WP_013017410.1\|2275064_2276105_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176197	cd08235, iditol_2_DH_like, L-iditol 2-dehydrogenase. Putative L-iditol 2-dehydrogenase based on annotation of some members in this subgroup. L-iditol 2-dehydrogenase catalyzes the NAD+-dependent conversion of L-iditol to L-sorbose in fructose and mannose metabolism. This enzyme is related to sorbitol dehydrogenase, alcohol dehydrogenase, and other medium chain dehydrogenase/reductases. The zinc-dependent alcohol dehydrogenase (ADH-Zn)-like family of proteins is a diverse group of proteins related to the first identified member, class I mammalian ADH. This group is also called the medium chain dehydrogenases/reductase family (MDR) to highlight its broad range of activities and to distinguish from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal GroES-like catalytic domain. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	3.66717e-169
NC_013947.1\|WP_041625899.1\|2257970_2260370_+\|TraM-recognition-domain-containing-protein	gnl\|CDD\|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	1.30218e-25
NC_013947.1\|WP_013017394.1\|2256087_2257719_+\|FAD-dependent-monooxygenase	gnl\|CDD\|235704	PRK06126, PRK06126, hypothetical protein; Provisional.	8.46732e-80
NC_013947.1\|WP_013017398.1\|2262643_2264452_+\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	1.6953e-132
NC_013947.1\|WP_013017397.1\|2261082_2262582_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.27587e-120
NC_013947.1\|WP_169313871.1\|2265409_2266579_-\|ATP-grasp-domain-containing-protein	gnl\|CDD\|180883	PRK07206, PRK07206, hypothetical protein; Provisional.	6.13152e-69
NC_013947.1\|WP_013017407.1\|2272162_2273104_+\|1-phosphofructokinase	gnl\|CDD\|274804	TIGR03828, pfkB, 1-phosphofructokinase. This enzyme acts in concert with the fructose-specific phosphotransferase system (PTS) which imports fructose as fructose-1-phosphate. The action of 1-phosphofructokinase results in beta-D-fructose-1,6-bisphosphate and is an entry point into glycolysis (GenProp0688).	8.07394e-105
NC_013947.1\|WP_013017406.1\|2271404_2272166_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	3.74014e-83
NC_013947.1\|WP_013017399.1\|2264465_2265413_-\|EamA-family-transporter	gnl\|CDD\|227339	COG5006, rhtA, Threonine/homoserine efflux transporter [Amino acid transport and metabolism].	0.00790219
NC_013947.1\|WP_013017412.1\|2276588_2278205_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	2.89095e-160
NC_013947.1\|WP_052304970.1\|2255137_2256091_+\|aspartyl/asparaginyl-beta-hydroxylase-domain-containing-protein	gnl\|CDD\|377460	pfam05118, Asp_Arg_Hydrox, Aspartyl/Asparaginyl beta-hydroxylase. Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyze oxidative reactions in a range of metabolic processes. Proline 3-hydroxylase hydroxylates proline at position 3, the first of a 2-OG oxygenase catalyzing oxidation of a free alpha-amino acid. The structure of proline 3-hydroxylase contains the conserved motifs present in other 2-OG oxygenases including a jelly roll strand core and residues binding iron and 2-oxoglutarate, consistent with divergent evolution within the extended family. This family represent the arginine, asparagine and proline hydroxylases. The aspartyl/asparaginyl beta-hydroxylase (EC:1.14.11.16) specifically hydroxylates one aspartic or asparagine residue in certain epidermal growth factor-like domains of a number of proteins.	2.01454e-17

>NC_013947.1|WP_013017401.1|2266929_2267373_+|hypothetical-protein
MTNSIDINIAQVQGYAERLRIAAEQLREQRPQLLARLANGDGVSPVVKVKDDVKVAIGIPPFEHSGSRAGETIAQKIRSCGDAYEAVEEGLRAMAIVMAKMAGSLGDGDAINAADLNKAVEGLHSVALVVNGEEPESVDWFGLEGGK
>NC_013947.1|WP_169313871.1|2265409_2266579_-|ATP-grasp-domain-containing-protein
MSTVHVYQPELRHFCDSGLFAAEDEIPHESFTDTTQTLKRLRVHAVLAGGELGVTLSEELAAALALPHNELSRTRARRDKFAMARTLRRHGIPVARTERISGLGELGPALRRIGRWPIVVKPVGSAASDGVTVCRSESRLREAVAGLLNTRNLMDQQNTSVLLQEYLDGPQYSIDSVSRNGRHLPCAVTVHRFEDVDGFPLWRGRRSLTRLDAAEHGIVDYTLRCLDALGITDSASNAEVRLTANGPRLVEVNARLGGPALPTDLFFRAFGYSPATLLADSILDNESFTGRLGRPYAPKRCMATVALVPPADGIVRAMPGLDAIRDLPTFHSLAKLPAVGSVIENRLLNLANGGVACFIDEDPDAVAVDVEQLHRIEAESRLFVMDTAP
>NC_013947.1|WP_013017399.1|2264465_2265413_-|EamA-family-transporter
MKYALLIIAAAALQATGNGLLTGNIDGSESIVLSFCAFGSSAIIFGLLNQRRRLTSTAAPPPGNVRVPLLLMNIATALAFIGLYWSYSMFPAPLASATGIAIGPLSVSLIDRLTGGSRRSNGELVVGAVSLGLVLAVASRSISLGTVALDGAFVLGFGIAIAAGALFACIPILSHRLGTTGVGPVRILAHRYHLTYIAAFAILMATPHAAMDTITGPRLPFIACVALIGVALPIFLLQLSMKHVQPVFLALIFSIQPSLTYLAAVVATELRFDAISFVLINASLCVAFGGPLLLHRRERARRARPALRPTTTTTA
>NC_013947.1|WP_013017398.1|2262643_2264452_+|glycoside-hydrolase-family-15-protein
MPRKVEDYALLGDTQTAALVGRDGSVDWLCLPRFDSPACFAALLDDETAGCWQLGPADGGDADRRRYRGDTLILESEWDTSQGTVRVIDFMPPRGEAADVVRIVEGLSGSVPMRMTLRLRFDYGSVVPWVRHDSGDLAAVAGPDAVWLNTPVSLHGANMASTAEFTVAEGQRIPFVLTYQDSHKPRPRPVVPEVALEETASFWEEWLDQIDYQGKWQPEVRRALVHLKALTYQPTGGIMAAATTSLPEQLGGPRNWDYRFCWLRDAAFTLQALLGTGYVDEAAAWREWLLRAIAGGPSDLQIMYALDGTRRIPEYTLDWLSGYEGSTPVRVGNAASEQLQLDVWGEVLDCMHQAREAGLAATEAGWDLQRALLEFLEDNWREPDNGLWEIRGPRRHFTHSKIMAWAGFDRAVTAVEKFGLPGEAKRWRGLCDRIHAEVCEQGFDAERGTFTQFYGSRGLDAALLLIPRVGFLPWDDPRVAGTVEAVQRELCVDGLLLRYRPQEDGNVDGLPGDEGAFLACSFWLVDALHGMGKRAEAHELFERLLDLRNDVGMLAEQYDTRLGRQLGNTPQAFSLVGLVNSARQLSGSATRTSASGSQQDTD
>NC_013947.1|WP_013017397.1|2261082_2262582_+|serine/threonine-protein-kinase
MPTPDETPIGREPTRESLPPTAIVSDRYRLDHRIGSGGMGEVWSGLDTRLERPVAVKLMHHELSGNKRFRARFASEAKLVAALDSPHVATLYDYGEEATPGGPRSYLVMEMVRGGSLADLLDTRDTLAPGETMKIIAQAAEGLQAAHDAGIIHRDVKPGNILVTGDRHVKLIDFGIARAKGEARLTKSGEAVLGTLAYTSPEQLNGDEPTPSVDVYSLGVVAYECLAGRPPFASDNPGAVLKGHLYQQPPPLPDNVPAPVAEAVMRALDKDPEQRWTSTAAFAQACRDAVEAPEPLPVKVSAPVGGPESEATTVPLGPTGPVPSSGTRRIGFGRVAAVLAAVVLLVAVAVLWRPWTYFGEAPGHDGSKEAATKDVADSSDGKSDKSSEKDKTKNSASSKSEAAEGGQSSDSGGNDSSSGGDDGNGNERVEVPDLEGRTHTEAPNVLESHGFDNYKGVAQPWNPGDQACVVTSQVPVAGAKVDPDTKINFYFKGGEGICQ
>NC_013947.1|WP_013017396.1|2260397_2261042_+|hypothetical-protein
MSDFGYAQSLHELRQLRDGDLAANTTARSQVEQATAKVARLRETLEHTQAQILAAANRFKTTVPDLRPESTDPAATRPATDLSAELAAGAAKAQLADKHVQRSIREGQLAPLLPGAPAFVRNLVVYGAAMIACYLIQSFLALFATDELALWLVFMPPVIALVAGYVGTGLAGTPRLPIYDDRGNTVEFVVKKSPRLGAALAVITIVAFFFTTAP
>NC_013947.1|WP_041625899.1|2257970_2260370_+|TraM-recognition-domain-containing-protein
MSQSAQKLTPGFLGEDLNQLPPDTPPREQEPPSPVHIRIGTAEAVPGAEFPVVVPLFGRGHLVLDGDAADAKVAGLLRSALVRCVASMPRLKVSLVDCVALGKTFTDAATLVKADIMAPTVTDAPGLERLVGEAEHYVQEVLDARHQGAAELPHHLIVIAGFPPSTSSALRGRIAALAHAGPHGRTHFILAGWRAESEHQQVPAIDHATYVNVGETVEVQNVPAPVTLDAPPSPTLTHHVFHALADKHRKDSQLDMGALLPPDRWRSSSVAGLSTVVGRDPRGDVELAFDDVTPHWLIGGRSGGGKTVFLLDVLYGLASRYGPRELALYLLDFKEGVSFTEFSPQPRDKTWMPHVKAVGVESDREYGKAVLVELRKELSRRATAMKRAGVTKLADLRQVEPDRPLPRILAVIDEFQVLFAGNDRLAREAADHLEELARKGRSYGVHLILASQTISGVEALYTKKDSIFGQFPMRVALPGARNVLDEVNNTAADAIRLGQAVVNNGGGVKGFNRLIHFPDATAATDELTALRHELWQQREPDDLGPRVFQGFAEQHLADDPVYNAVGPGGLRRKALVGRAVDVDVSTVGFGMEPVPGRNLAVLGTSTVGADVLQAAVLSLAKQHEPGSARFELVGLAAQADVVVTETAAALSEAGHEHEVTGAADLDKILVAAENHDHAGQVRYVVVFGGDAISQIWNISQLMKFRALLKSGPTKGVHLLGWWRGFKRFSDDIGGSAGKEDVACLVALNVPGGDFGPFIGDLTSDYEPRENRALVFDRHDNTRRLIVPFVRPGRETEVGF
>NC_013947.1|WP_013017394.1|2256087_2257719_+|FAD-dependent-monooxygenase
MNWPGSGEGTTSRHGSWRRASERRFARHRPGPPTRTSVLIVGGGLAGLSTALFLSWHGVSCVLVEQHTDVPIHPRMRGLPPPLVELYRPLGLETRLTREADDFARRGSFDMVRAETLAAEHTPMGMNLDPTRATSSSPCRNIPISQDKTERVLRQRAVELGADIRFGVRLEGFSDDSTGVSARLRATDESLSSVRASYLVAADGPESALRERMGIGMAGPGEISRMLSIMFETDSRLILGDRTVHMAYLERPFPGTFLFCLDAEGQRWVLGCTDPDEWGKTNADCEALVQVALGRRVPIRLLTPIPGSNQPALRFALSAAVADRFSDGRVFLVGDAAHHIPPPGGFGGFCGVADAYNLAWKLAAVLEDRADRALLDSYDTERRPAAEFTVRQAMARAGERLGGHWSEDSTTIVDRTRVMTGYRYGPGPIIGAAPGAVGTRFPHLWLEPGKSTIDLFGSGFVLLTPTDGHAWTVASHDAVTIHRLDRSLPGVESDGAILVRPDGFVAWRSRTAVADPHATLTDVVNRILNGPSPIMAFAPPALT
>NC_013947.1|WP_052304970.1|2255137_2256091_+|aspartyl/asparaginyl-beta-hydroxylase-domain-containing-protein
MSTESLTARWESVPAVAVLDRDYDTEILANEVRALRAGPWNTRRADISTGLSTILPLRSPGGDPSRTDPGGAGPVDHADTPFLARAPRLARLLRGLPTTLLAAHLVALAPNIELKEHRDVKCGPPWGLVRLHIPIITNPAAVMVIDGHEYHWDAGRLWYGDFNRPHQARNSGDDTRIHLVLDCLLSADLLNLFPPEFRESLPLNDILLARPARAAPWPPRLRFRMPAAFAEWSLEEPASPPDATVLAELTPGRDGPVLRLDGQPAFGLVHLGDNEYRFTGWSEERTVKLESRHVICRVRLGTSVRETICLAERPGAS
>NC_013947.1|WP_013017392.1|2254141_2254768_+|hypothetical-protein
MGELTVIGASFGRTGTASVRFALEQLGFGPCHHIRHLFASDRHARDWLRVAEGEPADWHRLLFGFAATIAWPASCYWRELAEANPSAKVLLVHRDPSDWYASVARTLYRRRPKRPVAERDRVFERLIWNGVFDGRFTDPRHAMDVYRDHYREVRATIPSDRLIEVDAAKGWPPLCEELGVPVPDETFPHANATGEYPNRPRTTGAVRT
>NC_013947.1|WP_013017403.1|2269235_2269784_+|hypothetical-protein
MGIMADRLASMVVKATSPDGQIEGELRDRDAVSVAFRGDTYRHYTEYSLGTQLSRLALRMWTGYQRGYDEAVAEATGRPVSRSQETWDANRRRFRQEQAATTVTGMSTDGWIYIQNTGMTSWHVVIRQGTLSKLDEDQFVAELMDAYNTMITEYRFATADLRAKHYGVSFQPRNPPVKELRA
>NC_013947.1|WP_013017404.1|2269780_2270218_+|hypothetical-protein
MNDIPSDVTAVELNELWRVANIHFPKVENVYWEQIKAVHEVNGDPNDEKFGRCHPWWTAVACELERALFSSVGSLASAASALNRAVDAYAHVDGNSGKELTEVGKGLENIIKSEGSEPVDWTPPKDYQGPNFNQPDSWSEEHADD
>NC_013947.1|WP_013017405.1|2270210_2271305_+|hypothetical-protein
MTSTSRPPARGSENNGSGGSDGSGSGEDKVKGPTDKELEDAVNKLVEVAKKKAQEEADQARRSVEGKKSFEGDVLEYPYTREEVTKMIEDGAKEIKERFAAVYTPKPDDFDTMISRMQQVEAVLGAYEPSKNTTKETPVIGGGGDLELLRTSVSDMSDWQGKLKNAFVDNYLTPFPRITVTQGGLARFLRHQAEWMQAIYKRRRYDAKKTADQGVEAIEAIDDSKGSEAAIALAAIIGLATLLGPMGSSLAFGLGTSAVVAGTGIGAEFIEEDKEVPLGADTVQGVIDNVYKALEESDKTMVEEEGKVLDALKQIEGVVYPLVMGPDIDKGTELTPMRPAIVDTMDVEELKDGITVYDRHPGGS
>NC_013947.1|WP_013017406.1|2271404_2272166_+|DeoR/GlpR-transcriptional-regulator
MYAEERQQEILRRARAAGRVDVVTLAEALGVTAETVRRDLTVLERAGVVRRVHGGAIPIERIGFERAVATRDTVLTAEKERIAKAAVAEIPEDGAIILDAGTTTARLAQLIPTDRELTVVVNSPVLAATLGPNPNLTVLLLGGRVRGKTLATVDDWALRPLENLHVDVAFMGTNGCTIDRGLTTPDQAEAAAKRAMIAAARRVVVLADHTKVGTDHFARFGTMSDVDVIITDTGLDPELGAELDEAGIRVVQA
>NC_013947.1|WP_013017407.1|2272162_2273104_+|1-phosphofructokinase
MIVTVTLNPSVDRTLEIETLTHGRVNRAAHTHLDPGGKGVNVSRALVANGVDTRAILPCGGDEGDQLVRLLRGEGVRLTAVPIDGRTRSNVTLVEPDGTVTKINESGPELAETELTVVAATVRAAAEDAEWVVVSGTVPPGVTPEAFTEFCGELVSGGAKLAVDTSGEPLRAAARAGAALVKPNRHELSDVTGVALDSVTDVVNAAETLRRWGAGSVLASLGSKGAVLVDADGVLIGEPPSVVTRSAVGAGDAMLAGFLAAGAAGAKALTEALAWGSAAASLPGSRMPFPADLNRHGVRISPGDLTPLSHMDS
>NC_013947.1|WP_013017408.1|2273156_2274629_+|PTS-mannitol-transporter-subunit-IICB
MSNKIPAATDTSIKARIQRVGGHMAGMVMPNIGAFIAWGLITALFIPKGWIPNETMAALVDPMVKMLLPLLIAYTGGRMVHGHRGGVIGAVATVGIVVGADVPMFLGAMIMGPLAAYLMKLIDKPLESRIKPGFEMLVNNFSAGILGAGLAMLGLWGIGPVISKVTVFLGDQVKWLVEHNLLPLASLIVEPAKVLFLNNAINHGAFTPLGTVESKETGQSILFMIESNPGPGLGLLLAFLFFGPRKLRGSTPAAIAIQFLGGIHEIYFPYVLMKPRLILAVMAGGVTGVATFMITGVGLTSAPAPGSIFAFWLTSPPGNLVGMMTGVVLAAAASFAVAGLLLGFGRKADPADEAVAAVETAPTADTGAAVAIPAPATSPETDADRTEIAAELRVEDISKIVVACDAGMGSSVMLASQLRKQLKDHDVTVEHTPVDAIPADADVIICHEGLAERARSTAPGKPVIPIQVFLGDPAVTSLIATIKKGGVLNV
>NC_013947.1|WP_013017409.1|2274621_2275068_+|PTS-sugar-transporter-subunit-IIA
MSELLTENAVRLTETAADRDTAIRRCGEVLVEIGAATPDYVDAMLEREKSISTYVGEGVAIPHGTVASKSAITRDALAVLRFPDGVDWGGSEVRVCVAIAARGEGHVELLSALAEVLMDPDSAERLREATDAQTVLNLLESIGKDSAV
>NC_013947.1|WP_013017410.1|2275064_2276105_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MKVVRFHAPGNVAIEDAPAPSPGPGEVLLRVGACSTCGTDVKISRFGHHHIVPPRVMGHEIAGEIAELGDGVADWAVGDRVQVIAAIPCGQCEICKAGRMTVCPNQESMGYHYDGGFASHVVVPAKVLAVDGLNRIPEELSFAEASVAEPLACVLNGQELARVGVGDDVLVIGSGPIGCLHVRLARARGASRVFLADLSRKRLDLAAGIVSPDATICSGDTDLVEAVAELTGGRGIDVAIVAAASGAAQEQALLTAARGGRVSLFGGLPKDNPVISLDANLVHYRELTVVGANGSSPAHNAEALRLIASGAVNVADLITHRLPLDRAIEAFDIVAGGEAIKVTIEP
>NC_013947.1|WP_013017411.1|2276116_2276401_+|HPr-family-phosphocarrier-protein
MATRTVTIGSSSGLHARPAKLFVEAASEQPVEVRISTAAKAAVPARSLLAVMALGAHQGTEVTLEADDGPEADSALDTLAALLARDLDAEPDNA
>NC_013947.1|WP_013017412.1|2276588_2278205_+|phosphoenolpyruvate--protein-phosphotransferase
MSETLRGIGVSPGLAAGPVRKLAPPPRLPAPAPVTDTDAEKARAAEALAAVARTLRARAAATTGAGADILNAEAMIVEDPMLAEAITTNIGNGADAPHAIDAAIAVHREAFQAAGGFLAERVSDLDDLRNRAVAHCLGQPSPGIPDPGHPFILVAADLAPADTAGLDTSMVLALVTETGGPTSHTAILARAAGLPAVVGCPNVLDLDDDTLISVDGTEGTVTTAVDDAEVARVVAAEQSRRQAEATATGPGRTSDGHRVALLANIGSAADLPSDGDYEGVGLFRTELLYLDRTTAPTLTEQNTAYREVFEAMGDRPIVVRTLDAGADKPLPFLSQTGEPNPALGVRGLRLARQQPNILDTQLSAIAEAASDTGADVRVMAPMVSTVAEASDFAARARWAGLEKVGVMVEVPAIALLAEDLVEVVDFLSIGSNDLSQYLFAADRQSSAMPDLLDPAQPALLRLIARCAEAGAASGTPVGVCGEAAARPDLAVVLTGLGVTSLSMSARALAAVRHALSRHTMDECRDLAGAALSGALVKD

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Crispr_ID: NC_013947_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_6

2937371-2937591

Orphan

Consensus_repeat	Method
GCCGCACGGCCCTTGGCN	CRT

5 spacers

The CRISPR arrays of NC_013947_6

>merge|NC_013947|6|2937371-2937591|CRT
GCCGCACGGCCCTTGGCTCGCGCATCGGTTTTGGCTGTGCCGCACGGCCCTTGGCCTGCGCACCGGTTCTGGCTGCGCCACACGGCCCTTGGCTCGCGCACCGCGCGGCGGCTACTGCACGCCGCACGGCCCTTGGCCTGCGCATCGGTTTTGGCTGTGCCGCACGGCCCTTGGCTAGCGCACCGCGCACCGGCTCTGGCTGTGCCGCACGGCCCTTGGCT

>NC_013947|6|1|2937371-2937591|CRT
GCCGCACGGCCCTTGGCT	CGCGCATCGGTTTTGGCTGT
GCCGCACGGCCCTTGGCC	TGCGCACCGGTTCTGGCTGC
GCCACACGGCCCTTGGCT	CGCGCACCGCGCGGCGGCTACTGCAC
GCCGCACGGCCCTTGGCC	TGCGCATCGGTTTTGGCTGT
GCCGCACGGCCCTTGGCT	AGCGCACCGCGCACCGGCTCTGGCTGT
GCCGCACGGCCCTTGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013018041.1\|2942548_2943019_-\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|376622
NC_013947.1\|WP_013018035.1\|2934482_2935946_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_013947.1\|WP_013018034.1\|2933323_2934478_+\|epoxide-hydrolase	unknown	unknown	gnl\|CDD\|377658
NC_013947.1\|WP_013018029.1\|2926535_2926715_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300488.1\|2928860_2931962_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226415
NC_013947.1\|WP_013018036.1\|2936035_2937124_-\|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225755
NC_013947.1\|WP_013018037.1\|2937695_2938409_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NC_013947.1\|WP_144300487.1\|2926914_2927592_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018039.1\|2940195_2941776_-\|FMN-binding-glutamate-synthase-family-protein	unknown	unknown	gnl\|CDD\|239202
NC_013947.1\|WP_013018044.1\|2945397_2945733_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018038.1\|2938448_2940179_-\|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl\|CDD\|181661
NC_013947.1\|WP_083787107.1\|2928561_2928756_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NC_013947.1\|WP_144300784.1\|2927842_2928565_+\|XRE-family-transcriptional-regulator	unknown	unknown	unknown
NC_013947.1\|WP_013018040.1\|2941940_2942498_+\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|376622
NC_013947.1\|WP_013018042.1\|2943295_2943574_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_169313881.1\|2932091_2933231_+\|epoxide-hydrolase	unknown	unknown	gnl\|CDD\|377658
NC_013947.1\|WP_013018045.1\|2945851_2946274_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341390
NC_013947.1\|WP_013018043.1\|2943570_2945364_+\|thiamine-pyrophosphate-requiring-protein	unknown	unknown	gnl\|CDD\|181344
NC_013947.1\|WP_013018046.1\|2946329_2947133_-\|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274373
NC_013947.1\|WP_144300783.1\|2925763_2926378_-\|phospholipid-methyltransferase	unknown	unknown	gnl\|CDD\|226472

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013018041.1\|2942548_2943019_-\|hemerythrin-domain-containing-protein	gnl\|CDD\|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	0.000189487
NC_013947.1\|WP_013018035.1\|2934482_2935946_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.81888e-53
NC_013947.1\|WP_013018034.1\|2933323_2934478_+\|epoxide-hydrolase	gnl\|CDD\|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	5.23869e-59
NC_013947.1\|WP_083787107.1\|2928561_2928756_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	4.76731e-08
NC_013947.1\|WP_144300488.1\|2928860_2931962_-\|AAA-family-ATPase	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	5.71326e-35
NC_013947.1\|WP_013018036.1\|2936035_2937124_-\|winged-helix-turn-helix-domain-containing-protein	gnl\|CDD\|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	1.17533e-57
NC_013947.1\|WP_013018037.1\|2937695_2938409_-\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	2.67205e-19
NC_013947.1\|WP_013018046.1\|2946329_2947133_-\|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	2.45118e-86
NC_013947.1\|WP_013018039.1\|2940195_2941776_-\|FMN-binding-glutamate-synthase-family-protein	gnl\|CDD\|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	8.89441e-164
NC_013947.1\|WP_013018038.1\|2938448_2940179_-\|thiamine-pyrophosphate-binding-protein	gnl\|CDD\|181661	PRK09124, PRK09124, ubiquinone-dependent pyruvate dehydrogenase.	0
NC_013947.1\|WP_013018040.1\|2941940_2942498_+\|hemerythrin-domain-containing-protein	gnl\|CDD\|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	4.59146e-10
NC_013947.1\|WP_169313881.1\|2932091_2933231_+\|epoxide-hydrolase	gnl\|CDD\|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	4.32306e-61
NC_013947.1\|WP_013018045.1\|2945851_2946274_-\|CBS-domain-containing-protein	gnl\|CDD\|341390	cd04622, CBS_pair_HRP1_like, CBS pair domain found in Hypoxic Response Protein 1 (HRP1) -like proteinds. Mycobacterium tuberculosis adapts to cellular stresses by upregulation of the dormancy survival regulon. Hypoxic response protein 1 (HRP1) is encoded by one of the most strongly upregulated genes in the dormancy survival regulon. HRP1 is a 'CBS-domain-only protein; however unlike other CBS containing proteins it does not appear to bind AMP. The biological function of the protein remains unclear, but is thought to contribute to the modulation of the host immune response. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	8.6201e-47
NC_013947.1\|WP_013018043.1\|2943570_2945364_+\|thiamine-pyrophosphate-requiring-protein	gnl\|CDD\|181344	PRK08273, PRK08273, thiamine pyrophosphate protein; Provisional.	0
NC_013947.1\|WP_144300783.1\|2925763_2926378_-\|phospholipid-methyltransferase	gnl\|CDD\|226472	COG3963, COG3963, Phospholipid N-methyltransferase [Lipid metabolism].	5.19369e-27

>NC_013947.1|WP_013018036.1|2936035_2937124_-|winged-helix-turn-helix-domain-containing-protein
MTPHRLDRVEARRIAVRAQLLDAPRPTDLLDVARQLTLLQVDPTAAIAPSADLVAWSRLGSSYRPADLTRALEVERTMFEHNAMLRPMEDLRLHLADMAEYPADWEFGRKWLDDNESFRRDILELLKTSGPLLSRDIPDTSKVSWPSSGWTNNRNVTKMLEMLLKSGEVAITARQGRQRVWDLPERVYPADAKALSLEESHRLMNERRVRSLGIVRPNAFGSPGEQLSVADSGEPAVVEGIEGEWRVDPAAIGKPFSGRTALLSPFDRLVHDRDRAMELFDFEYILEMYKPKDKRRWGYFALPILHGDRLVGKLDAKADRKAGKLDVFAIHEDVPFTKAISKGVRDEIQDLAQWLGLDPVWT
>NC_013947.1|WP_013018035.1|2934482_2935946_+|MFS-transporter
MAIIEATPETTASTQPAPTSTPAPYRWRWIALAVAMSGMAMELLDASVTSVAGPTMRAELGGGPSLIQWLTAGYTLAMVGGLLIGARLGDIFGRKRMFLFGATGFTLTSLLVALSQNPEFAIGSRVAQGLFGAAMVPQVFGLIKAMFPPSETQKAFSLAGPIMGMSAIGGPILAGWLIGLNLFDSGWRLVFLINLPIGIAIVALAFRLLPRDEPATVKSLDLAGATLAILASTSMVYPLVQGHEAGWPAWSFGMIAASVVLFAVFGAHQVRRNRRGRDVLVLPSLFHKRAFNGGLVLGVLLIAAMTGLGFVMTLHLQLGLAYTPLEAAAAMVPFAVAMSAAMGAGPALAKYGRKTLMAGALIKTAGIGAIILALALAGADLTWYHLAPGLMLSGVGAALFMGRYFDSVMEGVEPREIGSASGTLTAVQQLGASFGVALLGTAFFATYGPDVDSAVTASGTTLGLTGLILLVGFAVGFCLPKQTRTAD
>NC_013947.1|WP_013018034.1|2933323_2934478_+|epoxide-hydrolase
MSNETAITPFTIDIPQSELDYVRERLTRTRFAQEIPGAGTDYGVPTERVQHLVDHWLNNYDWREWEAKLNAYPQFTTEIDGQNIHFLHVKSPEPDAIPLLLTHGWPGSVVEYLDVIDALSDPKAHGSDGPAFHLVIPSLPGFGFSGPTTDRGWGTVRTAKAMGELMNRLGYQRYGQHGNDGGSMIAPELGRQDPDAQIGVHVNQAFSFPSGDPSEMENLTEEEGQALQVLGMFWEEKGAFNVLHSQQPNTLAHALADSPVGLLGWNDQLMGAEVSDDFVITNVLIYWLTNTSGSSIRFYYEDKKNPPSTEPTTFPLGVSNHANDFQGIRRFVDRDHKNIVQWRFHDEGGHYSDHQIPEIAVADIRDFFGELASRSDKHSRKVQE
>NC_013947.1|WP_169313881.1|2932091_2933231_+|epoxide-hydrolase
MEPFRINISQSDLDDLNTRIDATRWPAAYPGAAWSRGVPLSYLRRITEYWRHEYSWRAAEAKLNEFPQFTTEIDGHNIHFLHVTSPHPDAIPLLLTHGWPGSIVEFTGIIGPLTDPKAHGADGPAFHLVIPSLPGYGFSGPSPDEGWTTRRIAKAWAELMSRLGYDRYVAQGGDRGVGVTRDLGIVDPEHVAAVHVNGGFTFPGGADPDDETLSERERIRVRRMQEFMSESGAYLALHSSRPYSVAYAFNDSPVGLLAWIIERFKDWSDPAKQLPEDAVDLDQLLTNVCVYWFTQTAGSAANAYYEDAVSGAGWGPKEPSTVPAGVAQFTTQDIALRRDDEAANNIVHWAEYFRGGHFAAMEAPDLLVADLREFFGRHH
>NC_013947.1|WP_144300488.1|2928860_2931962_-|AAA-family-ATPase
MAPRVISPVLIGRSPELARLMDAHGASSRAARVCLVSGEAGIGKTRLLREFASRLDDRVRVLTGECLELGAEGLPYAPFLAVIRQLIREHGVAAITRTLPGDGPYALASWLPAIGEPLSGVDAELGRIRLFGEVLALLEGLATQRPLVLVLEDLHWADPSSRALLGFLAGSLTAPDVLIVGSFRSTDVEGAHPLCELVIRLTRDPAVTSISLRRLSVHEVGRQLAAIHNREPDPHRITQVYQRSDGNPLFVEALSTAEPGDPVPLRSLLLSGVDDLSEAAGLVLRHAAVAGNQVGHRLLSAVLPLADTEAESAIRALADRHLLVITEDGYRFRHALIRDAVYERLLPGERIRLHRGFAETLRDHPDAVPAERLPAELAAHWHAAENVEEALAHAWRAARVAATAYAYDEQQRMLELVLDLWPRAKDPAARLGVDRDAVVELAATACVHSGDFTRGDELVSALLEPAVDDPDGAGDPERVAALLELRGVLRNRHNTSGLPDIEAALALLPSDEPTRLRGRLLAALAHTRISVRDLAEVREPATEAVRIARLHDDPGTLAKALAALGVAEGLETGVDAAEPVFAEATELTQRLGDHPTLMSISQWHGNVLVNGGQFRKAATAIRRGIAAAERLGLIHSRGPALSISLGFALEQLGDWPEAAKVYRDGLSWTAAPLYRIGLLRGLGGIAIATGELDEAQLLATEIDALVDAANTAPTWRVEQATYRFRLAMAREEHDEAETIMRRLLDDFAVVSNSTSGWYVLSLAADLRSRRSSADAGWRRELLALAEPLTIPGRFEAAHRAGFLAAVDHEDPSGWRSAATLWRELEAPHQLGWCLVGLAEALRASGQAAEAIRARGQAADSPPRASGQAADALLRTSGQATDALLRTSGQASDAPLRTSGQAADALLRGRGQAADVPLRARGQASDAPLREAATIAAKLGARPLAERVARLAAQVGIAVGEAPQANPGPGRGLTAREVDVLRLLAKGLSNRQIAGELFISVSTAGVHVSRILAKLEVASRGEAAALAHREQWFG
>NC_013947.1|WP_083787107.1|2928561_2928756_+|DUF397-domain-containing-protein
MTYRPSSWRRSSRSGTNTNNNCVEVRLDGRTPQVSDSQFVGRRPIVELDRTDYLAFLATVKSDL
>NC_013947.1|WP_144300784.1|2927842_2928565_+|XRE-family-transcriptional-regulator
MCSDRTLLDIEEGRKRVVKRGFVRDICAFYKTDRVLIEHLVKLADATYMDDWTDAYAGVIDKDGWLYLQREERASRAVFHDSTAIPSLIQPRSYVEVILRTTKVSYDDAEAEWDQTIRFREARRSRWLKSRRSIVCLIGEAAFAVDLGAQANDELRQHVLELSTLPFADIRVIPFAAGRYDLMGWEVNVLEFGEGEEPFIRVASPRGAGFVSAHSHRGKFFRGGVGHARDLSVPVREFFK
>NC_013947.1|WP_144300487.1|2926914_2927592_+|hypothetical-protein
MVGLFGGVATSYGQTILGGGWAALANSASPWVMFAFAAGVLVPGRWVTAALAGLLTQVGLVVGYYATTELRGFAAGMAAIVIWVAAGAVAGPVYGAAGSLFRYRPGADVAGSDAGVAGERPVAGADGSAVDGSRDRWWLVRSCAAGITGSVWIMEGLNFFNLARDVNSNSGPGIGAAWVYVVVGLLLPLVLARAVRERLFALLALAVATGLALVAGIVVNAAFFI
>NC_013947.1|WP_013018029.1|2926535_2926715_+|hypothetical-protein
MLRQRYIEFGETGDMGHVDGSNRARISGIGPGDRDGEVVMRENLTNLERSAVEPAVSQA
>NC_013947.1|WP_144300783.1|2925763_2926378_-|phospholipid-methyltransferase
MPPSQWHDRKLFFRHWLRAPGVTGAMLPSSRAMARTMGTVLEGYQSPTVAELGSGTGAVTAVIQQRLRGASPHLAIEIHEEFASRLQKLYPDVSVVNQSAADLEQILKEHQIDSLDVVISGLPFTAFTPQLQSDILDAVVGSLNEDGVFATHRYVGAGYFPAAQRFRALLESRFAEVTVSRPNFGNLPPARLLTARGPRKSPTT
>NC_013947.1|WP_013018037.1|2937695_2938409_-|VOC-family-protein
MIGKLQLVALDAADITGLSRFYRDLAGWTEAEGEDGWIVLDTHDGWQVALQEVPDHKPPQWPGQDLPQQAHLDLRVPDLEAALARVLELGGTLLQKNEAWYTVADPAGHPFDLCRNDEVTKPTLMGVMLDVPDAKQLTAFYAELLGKAVTFEADGMGMIGADGEQPVLFQQVEGYTAPQWPNPEHPQQVHMDVEVGDLDAAEKAVLGLGATRLEGGGETFRVFADPAGKPFCLVTSS
>NC_013947.1|WP_013018038.1|2938448_2940179_-|thiamine-pyrophosphate-binding-protein
MAKTVSETLVDGLVGCGITHVYGVVGDALNSVTDAIRRTDGIDWIATRHEEVAAFAAGAAAQLTGRLGVCAGTVGPGAIHLLNGLYDAAKSHAPVLAITGQVPLPELGSNYFQEVDNDHLFRDVSVFNRTITSPGQVPQLIEQAIEAAVSRRGVAVLSLPGDVGPQQVSGKPKVRVFNEPAASVPSDKLLDQAAKLINGRDRVTILAGAGASGARDAVLGLAGSLAAPIVVTLKGKETFDWDNPYQVGQTGLIGNPAAVAALEDCELLLMIGTDFPYRDWYPEGPTVVQIDAVSEHIGRRTRVDLGLVGDAALTVEALAPRLRGNESRRHLDKAVKAFRKWHVGQERLAAPDHDREPVGELRSLVDNPDHHIRPESVALAVNELADDTAIFTADTGMSTVWLSRFVQFRQGQRLLGSFNLGSMANAMPQAIGAATAFPDRQVIAFCGDGGLTMLLGDILTAVRYRLPVKLIVFDNHRLGMVKLEQEQAGLPEFGTVLPNPDLAAVAEAMGAKGIRVTEPGELHKGLAEAFAADGPVLVDVLTNPEEVSVPGKVLPGQAWGFAIAKVKETLRPQAHD
>NC_013947.1|WP_013018039.1|2940195_2941776_-|FMN-binding-glutamate-synthase-family-protein
MVRFTTPVLAVLLAAVALALSIAVSAWWLLAALPLAAVAAVGVLDVVQVRHSILRNYPVLGHFRFLLEALRPELQQYFIERNTDGRPFDRDARSLVYERAKGDNQEKAFGTELDVYAVGQEFLAHSIAPVSPPDEPHRVTVGGPQCAKPYRMALLNVSAMSFGALSANAILALNAGAKLGGFAHDTGEGGLSGYHLRPGGDLVWEIGSGYFGCRTAAGGFDPGLFTDKAGDPRVKCVSVKLSQGAKPGIGGVMPAAKMTPEIAAARGVPAHEKCVSPPGHSAFAGPVGLLEFVARLREASGGKPTGFKLCVGRPAEFLSVCKAMLSTGIKPDFIIVDGSEGGTGAAPLEFEDHMGMPLTDGLMFVHQALVGCGLRDDIRVAASGKIASGADIVKRLIQGADYTNAARAMMMALGCIQAQRCHTNTCPVGVTTQDPRRYRALVVDDKAQRVYRFQRETVKSANALIAAMGLTSPEQLRAEDLVRRTDDQTLRRFDESGHRLHDGELLYEPPRWWAHYWQQASADRYG
>NC_013947.1|WP_013018040.1|2941940_2942498_+|hemerythrin-domain-containing-protein
MVTKTDTNLISVVIADHRHIEGVFKELLNPATPHPRRQRLLEHVIGELVRHATAEERYLYPLARELLVDGDEAVDRELAEHVEAEAVMRNLERLDVADPRFLPHLENLIRIIRHHVGEEERVLLPKLDRAGEDSQLRELGLKMLRSKETASTVPHPDATDQPSADHLVDTGAGYVNRLRDHLTRT
>NC_013947.1|WP_013018041.1|2942548_2943019_-|hemerythrin-domain-containing-protein
MNAVAAITHDHDDIRDLIDRIGQDEQDAEFLISQLRLRLAAHDAATETQVYRELLRESPACSELVGTRTVQHRELEAKLDNVERDLGTADFSRSLTMFSHKVASEMESEESTVLPVLRQVFTSEWLDEVGRRYELRWLAEMDARIRQRDAAQEPTA
>NC_013947.1|WP_013018042.1|2943295_2943574_+|hypothetical-protein
MFDEIHSRHGRDGREARTALPVSPRLKAVTAASGALACLTLAAVLWATGWGPGWLAVVVLVIGVWAVADTGLQWHRYRVRNRDNPTRKGTQT
>NC_013947.1|WP_013018043.1|2943570_2945364_+|thiamine-pyrophosphate-requiring-protein
MTFTVADHILARLREWEVDTVFGYPGEGINGLLAAWQRDTKNAPRFVQARHEEMAAFAAVGYAKFSGRVGVCASTSGPGAIHLLNGLYDAKMDHVPVVAIIGQTERGAMGGTYQQEIDLPNLFKDVAGAYVHTVTVPEQLPNVLDRAIRTAVTRCAPTAVIIPQDVQELRFPGPNETFRPSPSSVGIERPVAVPDTDALGRAAEVLNAGHKVAILVGQGARDAAPEVAQVAELTGAGVAKALLGKDVLPDTLPFVTGATGLLGTRPSYEMIRDCDTLLAVGTSFPYAKFLPGIEQARGVQIDIDGGMIGMRYPFEVNLVGDAKATLRLLIPLLENNRNRSWRDKIEANVAQWWNVIEQQSTVSAKPTNPMRTFVEASKRLPDDAIVTCDSGSAATWYARHLKFGEHTRGSLSGTLASMGCGVPYGIGAKAAFPERPVWCFVGDGAMQMNGLAELLTVGRYWREWDNPHFVVVVLNNGELNQVSWEMRAMAGSPMFPESQTLPQLNYARFAHDIGMVGLEVGSPEDIPGAWDAAVAAEQPVVMDVHCDPNVPPIPPAASFEQIKSTTAALLKGDDNAWEVLKEGVMTKMKEMATRRRD
>NC_013947.1|WP_013018044.1|2945397_2945733_+|hypothetical-protein
MPQQQWSAKRERQYEKIKSSQKKRGASEDRAEEIAARTVNKNRAQSGEAKKSSKLSREDVSPQHRGGKRSGNRQGPGGPTLDQLYQEARRKNIRGRSTMNKAQLQRAVGRS
>NC_013947.1|WP_013018045.1|2945851_2946274_-|CBS-domain-containing-protein
MGAQISSVMTPNPVCVPQDASVSATAAIMRDNDIGSVIIMNDGRVSGIVTDRDLVVRGLAEGFNPQEAPVGAVASPSAICLAPDSSTADAVRQMRESSVRRLPVCDSAGHPVGIVSLGDLAEELDPESALADISAATPNI
>NC_013947.1|WP_013018046.1|2946329_2947133_-|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor
MRNATLSRTRTQPTPARREDLDPQVKPVLERMERLKKTDPRRRALRNTVVQRALPLADRLARRFEHRGQPLEDLTQVARLGLINAVDNFKCGRGGGFTHFAVPSILGELKRHFRDKGWLVRVPRRLQETRLAFNEASKDLSQRLGRSPTLEDYAEYLSMPVEQVRAGINCVGAYEGVSLHTPAHRESSEELIDSLGGSDPAMASAEARMLLRPAIKELTPRECRILSLRFVDDLHQSEIAREVGLSQMHVSRLLRQTLTKLRERLDA

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Crispr_ID: NC_013947_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_7

3399945-3400018

Orphan

Consensus_repeat	Method
TCACCGTTCCCGGTCGTGCTCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_7

>merge|NC_013947|7|3399945-3400018|CRISPRCasFinder
TCACCGTTCCCGGTCGTGCTCCCCGCTAGCCTCGTGCGGCGGGGCCGTCCTCACCGTTCCCGGTCGGGCTCCCC

>NC_013947|7|6|3399945-3400018|CRISPRCasFinder
TCACCGTTCCCGGTCGTGCTCCCC	GCTAGCCTCGTGCGGCGGGGCCGTCC
TCACCGTTCCCGGTCGGGCTCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013018453.1\|3389291_3391664_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|223256
NC_013947.1\|WP_013018469.1\|3408556_3408826_+\|DUF2277-domain-containing-protein	unknown	unknown	gnl\|CDD\|378364
NC_013947.1\|WP_013018460.1\|3399186_3399729_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NC_013947.1\|WP_041624941.1\|3404624_3405089_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240041
NC_013947.1\|WP_013018459.1\|3398704_3399118_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319924
NC_013947.1\|WP_013018471.1\|3410007_3410583_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013947.1\|WP_013018451.1\|3387374_3388292_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|223532
NC_013947.1\|WP_013018462.1\|3401223_3402237_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271179
NC_013947.1\|WP_041626295.1\|3402243_3402846_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013947.1\|WP_013018464.1\|3402910_3403807_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235737
NC_013947.1\|WP_013018454.1\|3391720_3393019_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_013947.1\|WP_013018466.1\|3405172_3405970_+\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197336
NC_013947.1\|WP_013018456.1\|3393741_3394095_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319911
NC_013947.1\|WP_013018455.1\|3393080_3393695_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319914
NC_013947.1\|WP_144300512.1\|3408090_3408423_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018457.1\|3394235_3397031_+\|ATPase	unknown	unknown	gnl\|CDD\|226418
NC_013947.1\|WP_013018452.1\|3388349_3389132_-\|serine-protease	unknown	unknown	gnl\|CDD\|238113
NC_013947.1\|WP_013018458.1\|3397193_3398660_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|235870
NC_013947.1\|WP_144300806.1\|3408961_3409855_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_013947.1\|WP_013018467.1\|3405999_3408075_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223588

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013018453.1\|3389291_3391664_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|223256	COG0178, UvrA, Excinuclease ATPase subunit [DNA replication, recombination, and repair].	0
NC_013947.1\|WP_013018469.1\|3408556_3408826_+\|DUF2277-domain-containing-protein	gnl\|CDD\|378364	pfam10041, DUF2277, Uncharacterized conserved protein (DUF2277). Members of this family of hypothetical bacterial proteins have no known function.	4.71701e-36
NC_013947.1\|WP_013018460.1\|3399186_3399729_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	4.23202e-25
NC_013947.1\|WP_041624941.1\|3404624_3405089_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240041	cd04685, Nudix_Hydrolase_26, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.65292e-19
NC_013947.1\|WP_013018459.1\|3398704_3399118_-\|VOC-family-protein	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.05234e-40
NC_013947.1\|WP_013018471.1\|3410007_3410583_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.02323e-10
NC_013947.1\|WP_013018451.1\|3387374_3388292_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|223532	COG0456, RimI, Acetyltransferases [General function prediction only].	1.53235e-11
NC_013947.1\|WP_013018462.1\|3401223_3402237_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271179	cd00798, INT_XerDC_C, XerD and XerC integrases, C-terminal catalytic domains. XerDC-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance. They share the same fold in their catalytic domain containing six conserved active site residues and the overall reaction mechanism with the DNA breaking-rejoining enzyme superfamily. In Escherichia coli, the Xer site-specific recombination system acts to convert dimeric chromosomes, which are formed by homologous recombination to monomers. Two related recombinases, XerC and XerD, bind cooperatively to a recombination site present in the E. coli chromosome. Each recombinase catalyzes the exchange of one pair of DNA strand in a reaction that proceeds through a Holliday junction intermediate. These enzymes can bridge two different and well-separated DNA sequences called arm- and core-sites. The C-terminal domain binds, cleaves, and re-ligates DNA strands at the core-sites, while the N-terminal domain is largely responsible for high-affinity binding to the arm-type sites.	8.97819e-33
NC_013947.1\|WP_041626295.1\|3402243_3402846_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.55247e-11
NC_013947.1\|WP_013018464.1\|3402910_3403807_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	5.87058e-122
NC_013947.1\|WP_013018454.1\|3391720_3393019_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.74505e-45
NC_013947.1\|WP_013018466.1\|3405172_3405970_+\|exodeoxyribonuclease-III	gnl\|CDD\|197336	cd10281, Nape_like_AP-endo, Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Neisseria meningitides Nape and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Neisseria meningitides Nape and NExo. Nape, found in this subfamily, is the dominant AP endonuclease. It exhibits strong AP endonuclease activity, and also exhibits 3'-5'exonuclease and 3'-deoxyribose phosphodiesterase activities.	1.09448e-135
NC_013947.1\|WP_013018456.1\|3393741_3394095_-\|glyoxalase	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	1.05239e-12
NC_013947.1\|WP_013018455.1\|3393080_3393695_-\|glyoxalase	gnl\|CDD\|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.39068e-13
NC_013947.1\|WP_013018457.1\|3394235_3397031_+\|ATPase	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	3.56511e-51
NC_013947.1\|WP_013018452.1\|3388349_3389132_-\|serine-protease	gnl\|CDD\|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	1.89227e-52
NC_013947.1\|WP_013018458.1\|3397193_3398660_+\|FAD-dependent-monooxygenase	gnl\|CDD\|235870	PRK06834, PRK06834, hypothetical protein; Provisional.	8.75017e-147
NC_013947.1\|WP_144300806.1\|3408961_3409855_-\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.33969e-11
NC_013947.1\|WP_013018467.1\|3405999_3408075_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	4.21043e-129

>NC_013947.1|WP_013018460.1|3399186_3399729_-|GNAT-family-N-acetyltransferase
MLKGSKVGLRARHDDDIAILRTELYDDVVNASRAEGPPWRPITPGSNDKRLVVDDSAQGLVQFSVVDVDSDALVGTATLWGIDPHHRSAHIGLGLLPSCRGKGYGTDVVAVLCYYGFTVRGLHRLQIETLADNVGMLRSAERNGFVREGVRRASTWVLGEFLDEVVMGLLAHEWKPDADS
>NC_013947.1|WP_013018459.1|3398704_3399118_-|VOC-family-protein
MDITIQSSFLPHTDAEASLAFYRDVLGFEVRGDVGNDRMRWITVGPVDQPGTSIVLEPPAVDPGVTDAERHTIEEMIAKGTYGYILLGTSDVDATFAKVKDAGGEVAHEPTDQPWGVRDCAFRDPAGNMVRIQQTQA
>NC_013947.1|WP_013018458.1|3397193_3398660_+|FAD-dependent-monooxygenase
MHTPPPSTDHEPDTFDVIIVGCGPTGAMLAAELRLHGIRVLVLETETGPTSFVRIVGLHIRSIELLAMRGLLDRVAPHARQRPAAGFFAAIDKPAPTGLDTAHPYLLGIPQPVIVRLLEEHATDLGARVQHGVAVTGVEPDDDGVTVTLDDGRCMRSRYLVGCDGARSTVRKQLGIAFDGQPAQTQTLMGEMEAGVAPDEIAAAMRRIGQGDRRWWLRPVGVGLYSVVVPAEGVTDRATPPTLEDVRRQLRAVAGTDFGVHSPRWLSRFGDATLLAERFRVGRVLLAGDAAHIHPPLGGQGLNLGVQDAFNLGWKLAAHIRGWAPVTLLDTYQAERRPVAADVLDNTRAQMALQGSEPGAQAMRRLVSELMDFDAVNRHLIAKITAIDIRYDFGDGPDLLGRRLPDLTTKQGRLYGLLHRGRGLLLDRTGRLGVGAWSDRVDYLPDPAAELNAACVLLRPDGHVAWIGDDQDDLDEQLARWFGQPNQP
>NC_013947.1|WP_013018457.1|3394235_3397031_+|ATPase
MTVEISTRESEVLALVGDHLSNAEIAARLFISVRTVESHVSALLRKLAVPDRRALARHAPDHTHKSTAVPVLPRPLTSFIGREAERAALADLVTTHRQVTALGPGGVGKTRLALRVAAAVTAHFDDGVWFVDLVSTTDPDLVAAAVAAALGLGEQPDRGMHESVISALSSQHALVVLDNCEQVVDAVAAFLERLLSACPRLSVLATSRARLMVPFEHVYPVPPLSLSGDGDSDAVELFTQRAAAAGQAPDASTREAIAHLCQRLDGMALAIELAAARWPTLGLDGLTAALSDPLRMLSGGSRAADRHRSVRAALDWSHALLAPDDQKLLRRVAVFAAPFTMAAAVHVTGIDAGVVADGLARLSEQSLLTAVSTANGTRYRGLETIRQYGTERLADADEESATRQRHVAWCLATATDLTQALPDWRARFDTVADELRAALAWASRQAEHRADAHDLAARLAALTFTRGLIGESQQRHEQAAALATDPRDAAVMLRGAAAVAACRMRGDDMYRLHLAAADAARDARDTPAAARDLATAATHAYRFSGKFTHLPSHDEVVALIDQARDLAGDDPDAVAAVALAEAGVLYDAFGAAQGPADNNVPDTLAHARRAVALARDTGDAIAQSAALDTLTGAQSWGGDAFGVAATINNRITLVTPLSESPQRTLELTDALSQAIEAALGVGDLPGAREWVRRLAEHPLLTEVSFRATSWLLVIDALAGDVADIPDVGERFAEAWRRAGSPRSTHLAPAAAAAVMAHDLGGDETARREWEQALDHLGTLPGHAFSYLAIFDSIRFLHDGDVERAWERTAPEPDDVWKWVTWLWLHWYVAVRCEAAVLAGRPDAAQHVAKARTVVAANPVAGAMVERADALLKGDRDRVAATARALTDAGCGYQAARSLVLAGGDHAARGQAALAKLGLRPMAPGPEIDWTR
>NC_013947.1|WP_013018456.1|3393741_3394095_-|glyoxalase
MTTQGIKTVLHPVSDLARAKTVYTALLGVEPQTDGPYYVGFDVEGQHIGLVPGGGPANMTCPVAYWHVADIDASLAGLTAAGATVAEAVHDVGAGRRVATVTDTDTDGNVLGLLQDA
>NC_013947.1|WP_013018455.1|3393080_3393695_-|glyoxalase
MTTIDAIILETPDPAAAEAFYAAAFDLKDRVRASASQAPTSGFRGYTMSLVVGQPSTVDSLVATALAAGATTLKPAKKSFWGYGAVVQDPFGTIWKIASSSKKNTEPDTRRIDEIVLLLGVSDVAVTKQFYADQGLSVAKSYGRKYVEFATANIKLALYGRRFAAKDAGVPIDGSGSHRLVIDSDAGTFTDPDGFAWNTAVATN
>NC_013947.1|WP_013018454.1|3391720_3393019_-|MFS-transporter
MSLIPSAYRPVLANRVFRRLIGGFGVSYLGDGMSFVAVAWLAIELAPPGTAGLWVGGAVAAYTLPGVVGAMVFARWLRRIPAKRLLLIDNVVRGVFLGAIPLAWSTGLLTPTLYVLLLAGSSLLHAWGNAGKYTLLAELLPPPQRLAANTLVSTLNFAATIAGPAIAGVLVTYVSSALVLGLDAATYVFLAVLVARTRLPASAPAAPVETAAARGGLALLRSHPALLGLLALTWFFNFLYGPVEVALPLHVTDDLHAPGTLLGAYWMLFGIGAVAGGLAVGALKRLPLWPVTVAIVIGWGALLLPFGLAAPTLVTIAAFTLGGAIYGPFVALSVTLMQTTSPPQHLAAMLAARSAVLLTASPLGTALGGPLTTALGPRSTLGASGLATVVVGVAAAILLLAWRTRRPEPLPAFATSPRGRGHDDHDSRSTTP
>NC_013947.1|WP_013018453.1|3389291_3391664_-|excinuclease-ABC-subunit-UvrA
MTRATDTTGHAADSHDLIRVHGARENNLNNVSVDLPKRRLTVFTGVSGSGKSSLVFATIAAESQRLINETYSAFVQGFMPTLARPEVDFLDGLTTAIIVDQERMGANPRSTVGTATDANAMLRILFSRLGKPHIGSPNAYSFNVPSVKASGAITVERGGKTKAEKATFNRLGGMCPRCEGMGSVTDFDLSALFDESKSLNDGALTIPGYSMDGWYGRIFRGCGFFDPDKPIRKFNKRERHDLLYKEATKIKVEGVNLTYAGLIPQIQKSFLSKDREAMQPHIRAFVDRAITFTTCPECDGTRLSPEARSSKIGGKNIADVCAMQISDLAEWVRGLDEPSVAPLLAGLQHLLDSFADIGLGYLSLDRPAGTLSGGEAQRTKMIRHLGSSLTDVTYVFDEPTIGLHPHDIQRMNALLLQLRDKGNTVLVVEHKPETIAIADHVVDLGPGAGTNGGTVCFEGDLAGLRASDTITGRHLDDRAALKDTVRSATGALEVRGAATHNLRDVDVDIPLGVLCVLTGVAGSGKSSLIDGSVAGREGVIAIDQGAIRGSRRSNPATYTGLLDPIRKAFAKVNGVKPGLFSANSEGACPACNGAGVIFTDLGVMATVESTCEECEGKRFGAQVLEYKLAGRDISEVLGMSVAQAEEFFASGEARIPAAHKILDRLADVGLGYLTLGQPLTTLSGGERQRLKLAAQMADKGDVYILDEPTTGLHLADVEQLLGLLDRLVDSGKSVIVIEHHQAVMAHADWIIDLGPGAGHDGGRIVFEGTPAELVAKRSTLTGEHLAEYVA
>NC_013947.1|WP_013018452.1|3388349_3389132_-|serine-protease
MRKRLIYSGLAVVAAAAVAVGGVGFAANADDGVDASDSQTKIIGGVDADQDYSFMASMQGSDGSHRCGASLISPEWLIIAAHCVEGEDPSGYQFRLNTKTVSDGGEVVKPTEFVVHPDYSGGVDDLALVKLEAAAESAPVKLGSEASPGTKSRILGWGATNPDGSGAPETLQQLDTAVVESSKCTEIGEKDLCTDNPNGDSGACYGDSGGPQIVDDGSGGWVLIGATSRSGNGDPTCATGPSIYTNVTAYTDWINETTGA
>NC_013947.1|WP_013018451.1|3387374_3388292_+|GNAT-family-N-acetyltransferase
MAASLAPVVPAGYRARPSQPDDVAAITALVAACEVDLFGRVESDAGHAHAVFARDGLDAGRDTVLVFGPGGEVVAWAWVNRRSEVYVHPAHRGRGLGSGLLAWIQRRARQAGTVTVAQQVPDSDTAAARLLGSAGFVVKARAWMLGIDTAGVTVAEVDGIAFRGYRTGDLRAAWQVTEDAFGDWKARRTPLREWAAGTVEQSAFAPGASAMAFDGDELVGALIALDVLGRGEGYVEYLAVASAYRGRGIARGLLRFCFAAFAEAGYGHCTLWTHTDTGALSLYERVGMSVERTASVYFKELGDNA
>NC_013947.1|WP_013018462.1|3401223_3402237_+|tyrosine-type-recombinase/integrase
MEQLPLPSHRAEDVAEKKTPHRDGAVAGVGDPVATYLGSLASPASRREMAACLNRIVRLSTGDDNATAAGQPWHKLTYRDTARLKETLCQQGWSAAHVNKHLVALRRVLTEAWRLGLMDAEQKDRACDIADVTSVRLPRGHHVAAEVIGAVLAACDADEAAAGRRDAAIIAVLYSTGCRRAEIAGLRLRDYDPAERGITVIGKGDKQRLVHLNAQAVAKVEAWLAVRGRGDGAMFSPISAAGRIRMRDGVPAGMSGQAIGHMLTRRLRQAGAPQASPHDLRRTFIGSLLDAGVDLATTQAIVGHASPATTARYDRRPDHRRREAIDRLELPQAKPLR
>NC_013947.1|WP_041626295.1|3402243_3402846_-|TetR/AcrR-family-transcriptional-regulator
MPQATDERPYHHGNLRTALLEAAQASLREHGAAQLSLRDLAREVGVSHAAPRRHFPDRQALLDALAENGFTQLDTILRTACADAGDDFAARLRATMTAYTRFATDNAALLELMYTSKHRPGATAIVKAAEAPFQLMIELLQQGQAQGALPSGAPERIGIILFATLQGIASLINGNFVEADLLDELVDTAVEQFLHGARPA
>NC_013947.1|WP_013018464.1|3402910_3403807_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTTFNASSIGSQAGRTFVVTGANSGIGRIAAKVLAERDARVVLAVRDEAKGRAAAATMTGQVEVKRLDLADLASVRAFAEDFTDPIDVLVNNAGVMIPPLTRTADGFELQFGTNHLGHFALTNLLLPQVRDRVVTVASMAHHGGAIDFDDLNWQRKPYRAMRAYGQSKLANLLFTTELQRRLSQAGSSVIATAAHPGFAATNLLRPGRSRLLHTVSKAVTRVVAQSEAAGALPTLYAAVTDVPGDSYAGPKGLFETRGAPKLVGRSAAAKDAEVAKRLWEVSQELTAVVFPRQSLPRA
>NC_013947.1|WP_041624941.1|3404624_3405089_-|NUDIX-domain-containing-protein
MAEIDRQSARVLCLDAHDRVLMLCWRDPVDAHLLWEPPGGGIEAGETPAQAARRELAEETGLTPRQWAPGSIDVTVTVRWKGQVFEATEPYFLARVDATAPDLSREGLQDYETTSLVEHRWVAWDAMAELPHESTPPDIPTILSRLDPSGPWAR
>NC_013947.1|WP_013018466.1|3405172_3405970_+|exodeoxyribonuclease-III
MLTVTTANVNGIRAAARKGFVEWLSDTTADVVCLQEVRATDEQVPVEVRDVDGWHMIVAPAADKGRAGVAVLSRETPARVQVGFGSEEFDVSGRYLEVDLPGVTVASLYLPSGETGTPRQDQKERFMAEFAEYLVALRKRAEADNRHVVICGDWNIAHQEIDLKNWKANKKTAGFLPEEREWMTRVFDDIGYVDVARRLHPEGPGPYSWWSYRGRAFDNDAGWRIDYHIATPGLAEAAKTAVVERAATHDARWSDHAPVTVTYAV
>NC_013947.1|WP_013018467.1|3405999_3408075_+|DEAD/DEAH-box-helicase
MNEVLDKAQTVLESLAGPEAVLRRDQATAIASLVTDRRRVLLVQRTGFGKSAVYFVATRLLRDQGAGPTVIVSPLLALMRNQIAAAESAGINARTVNSANTHEWDEIFADVAADAVDVLLVSPERLNNPDFRDLVLPKLAAAAGMLVVDEAHCISDWGHDFRPDYRRLKTFLAGLSPQVPVLATTATANARVSADVAEQLGGDTLVLRGGLDRSSLRLSVVDVDDNARRLAWLDTWLHRLDGSGIIYTLTVAAAHDIAEHLRGQGHDVAAYSGQTDTGERLRLEDDLLGNRVKALIATSALGMGFDKPDLGFVVHYGAPPSPVAYYQQVGRAGRARDRAEVVLLPGREDTRVWDYFASLAFPAEDVVRKTLEVLAEADRPLSSAVLESRVDLSRNRLEMMLKVLDVDGAVKRVKGGWQHTGRDWEYDRDRYERVAQTRRAEQRRMLDYAATTECRMAFLRTELDDADANACGRCDNCAGTAFDEPLPVEALAAAEASLNRPGVATEPRRMWPPGMAAAGIDVAGKIPVDERAETGRVLARLSDIGWGGALRALFADSGDTAVDEAMFAAVVKVLAAWDWPKRPDTVVSMGSRSRPGLVDGLARRIAEVGRMDYAGAMRRDAAAPSRTGASNSAQRLRQVWDTFQPPPVADGAVVLLVDDLRDSGWSATVAARQLRLAGAAAVCPLALALDG
>NC_013947.1|WP_144300512.1|3408090_3408423_-|hypothetical-protein
MRDTETRVFHPAAAQLSTSPNAKGDAVTTHATTPATTTQWQQLCVGLTSLHRASASGHCLACSRALAYPVPHPCPRSRMAAPVVAAIGRDAVFRAFGVADASGRDRHSHN
>NC_013947.1|WP_013018469.1|3408556_3408826_+|DUF2277-domain-containing-protein
MCRNIRRLHNFAPPATDTEIHDAALQYVRKVAGTTKPSQANQAAFDAAVAAVTAATATLLEQLVTTAPPRDREVERERAQARAQKRYGT
>NC_013947.1|WP_144300806.1|3408961_3409855_-|EamA-family-transporter
MWSSGFIGAELGTRAAPAATLLAWRFGLVGLAATVWLSWRWRRLAPRDIAVHALIGALSQVGYVYGVVRAAELGVSAGTSALIAALQPIVATATAAALLGEKLGWRLIVGLAVGLGGTGLVVSADLNSSASAVWWAYAIPVAAMLSLVAGTVYERRAHRGRQPVAMADALAVQFVVSGLAFVAIAAASGTLIPPARVEFWVAVAWVIVLSTIGGYGCYWTVVAHGGVTRVSALLYLTPPATAIWAWAMFGQPLTVLSLAGMAVSAAAVALILAPSRRRAPAPAPRRVETPQCEPAAT
>NC_013947.1|WP_013018471.1|3410007_3410583_+|TetR/AcrR-family-transcriptional-regulator
MPTVTPPRLTPAARRVLDVASTLFYERGINTVGMDLIAATAKVTKKTIYDRFGSKEALVTAYLSERDHTWRRHLDAQLADIPGPRAKILASFDVLAAWMGDNYRGCAMVNAYAELADPTHPARAVSTDQKKWLKNLFTDLLTQAGINDEHLAVQLVMLHEGSVVAAYVGGMTTAVAAARQAAATLLDTHGE

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Crispr_ID: NC_013947_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_8

3798824-3799945

TypeI

Consensus_repeat	Method
NGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	CRT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAG-------CGCCAC	PILER-CR
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	CRISPRCasFinder

15 spacers

cas3,cas5,cas8c,cas7b

The CRISPR arrays of NC_013947_8

>merge|NC_013947|8|3798824-3799945|CRT,PILER-CR,CRISPRCasFinder
CACTGCAATCCTCGCCAGAGGAGTGCTCCAGCGCCACCGGCAGCGCGCCGCCGTCCCGGACCCGGCGCTGCTGGTTGCGATCCTCGCTGGAACTGGTGCTCCAGCGCCACCACGAGCGGTCCCGGAGGAGACAGGCCCGGAGCAGGGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACATTCCGCTACGGCGGCGGTGGACAAGCTGGTGCGTGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACGAAGGCTTACCGCCCGTGCCAGGTTCGCCGTGTTGTTGCGATCCTCGCTGAAGCTGGTGCTCCAGCGCCACACTGGCAGAGCTGGAAAGCGATCAACCGCGAACAGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACGGTCCTCGTTGCCGCGTTGGTGTTGCGGACCTCGAGGTTGCGATCCTCGCTGGAGCTGGTGCTCCACCGCCACCGGCGTCCCACCGCGGCGGCTGCGGTGACGATCGGGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACCGTCGTGGTGGCGACGTGCTCACGGATCAACTCCTGGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACTGGCGTTGTACTCGTCTAGCGGCTGGTTAAGCCGCAGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACAGCTGCTTCCGTGGATTCAGTCGCACCCCAACATGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACCGGCAACGGAGCGTTGGCGAGGTTCTTGAGGACCTCGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACTGGAGTCGTGGACGTGCGCCGACGCCCACGAGATCCTGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACACGATCGCCAGCAGCAGCGGTCCCCACTCGCGGAAGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACACGATCGCCAGCAGCAGCGGTCCCCACTCGCGGAAGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCACAGGTCACCAATCCCAATCAGCTGGTCTTGCGCCATGTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC

>NC_013947|8|2|3798824-3799945|CRT
CACTGCAATCCTCGCCAGAGGAGTGCTCCAGCGCCAC	CGGCAGCGCGCCGCCGTCCCGGACCCGGCGCTGCTG
GTTGCGATCCTCGCTGGAACTGGTGCTCCAGCGCCAC	CACGAGCGGTCCCGGAGGAGACAGGCCCGGAGCAGG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	ATTCCGCTACGGCGGCGGTGGACAAGCTGGTGCGT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	GAAGGCTTACCGCCCGTGCCAGGTTCGCCGTGTT
GTTGCGATCCTCGCTGAAGCTGGTGCTCCAGCGCCAC	ACTGGCAGAGCTGGAAAGCGATCAACCGCGAACA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	GGTCCTCGTTGCCGCGTTGGTGTTGCGGACCTCGAG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCACCGCCAC	CGGCGTCCCACCGCGGCGGCTGCGGTGACGATCGG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	CGTCGTGGTGGCGACGTGCTCACGGATCAACTCCTG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	TGGCGTTGTACTCGTCTAGCGGCTGGTTAAGCCGCA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	AGCTGCTTCCGTGGATTCAGTCGCACCCCAACAT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	CGGCAACGGAGCGTTGGCGAGGTTCTTGAGGACCTC
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	TGGAGTCGTGGACGTGCGCCGACGCCCACGAGATCCT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	ACGATCGCCAGCAGCAGCGGTCCCCACTCGCGGAA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	ACGATCGCCAGCAGCAGCGGTCCCCACTCGCGGAA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	AGGTCACCAATCCCAATCAGCTGGTCTTGCGCCAT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC

>NC_013947|8|1|3798897-3799945|PILER-CR
GTTGCGATCCTCGCTGGAACTGGTGCTCCAGCGCCAC	CACGAGCGGTCCCGGAGGAGACAGGCCCGGAGCAGG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	ATTCCGCTACGGCGGCGGTGGACAAGCTGGTGCGT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	GAAGGCTTACCGCCCGTGCCAGGTTCGCCGTGTT
GTTGCGATCCTCGCTGAAGCTGGTGCTCCAGCGCCAC	ACTGGCAGAGCTGGAAAGCGATCAACCGCGAACA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	GGTCCTCGTTGCCGCGTTGGTGTTGCGGACCTCGAG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCACCGCCAC	CGGCGTCCCACCGCGGCGGCTGCGGTGACGATCGG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	CGTCGTGGTGGCGACGTGCTCACGGATCAACTCCTG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	TGGCGTTGTACTCGTCTAGCGGCTGGTTAAGCCGCA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	AGCTGCTTCCGTGGATTCAGTCGCACCCCAACAT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	CGGCAACGGAGCGTTGGCGAGGTTCTTGAGGACCTC
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	TGGAGTCGTGGACGTGCGCCGACGCCCACGAGATCCT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	ACGATCGCCAGCAGCAGCGGTCCCCACTCGCGGAA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	ACGATCGCCAGCAGCAGCGGTCCCCACTCGCGGAA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	AGGTCACCAATCCCAATCAGCTGGTCTTGCGCCAT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC

>NC_013947|8|7|3798897-3799945|CRISPRCasFinder
GTTGCGATCCTCGCTGGAACTGGTGCTCCAGCGCCAC	CACGAGCGGTCCCGGAGGAGACAGGCCCGGAGCAGG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	ATTCCGCTACGGCGGCGGTGGACAAGCTGGTGCGT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	GAAGGCTTACCGCCCGTGCCAGGTTCGCCGTGTT
GTTGCGATCCTCGCTGAAGCTGGTGCTCCAGCGCCAC	ACTGGCAGAGCTGGAAAGCGATCAACCGCGAACA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	GGTCCTCGTTGCCGCGTTGGTGTTGCGGACCTCGAG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCACCGCCAC	CGGCGTCCCACCGCGGCGGCTGCGGTGACGATCGG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	CGTCGTGGTGGCGACGTGCTCACGGATCAACTCCTG
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	TGGCGTTGTACTCGTCTAGCGGCTGGTTAAGCCGCA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	AGCTGCTTCCGTGGATTCAGTCGCACCCCAACAT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	CGGCAACGGAGCGTTGGCGAGGTTCTTGAGGACCTC
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	TGGAGTCGTGGACGTGCGCCGACGCCCACGAGATCCT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	ACGATCGCCAGCAGCAGCGGTCCCCACTCGCGGAA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	ACGATCGCCAGCAGCAGCGGTCCCCACTCGCGGAA
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC	AGGTCACCAATCCCAATCAGCTGGTCTTGCGCCAT
GTTGCGATCCTCGCTGGAGCTGGTGCTCCAGCGCCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013018822.1\|3813476_3816314_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_013947.1\|WP_013018811.1\|3793002_3793884_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_013947.1\|WP_013018805.1\|3786079_3788824_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226418
NC_013947.1\|WP_169313894.1\|3803704_3804400_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300812.1\|3790042_3790285_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133379
NC_013947.1\|WP_144300547.1\|3810153_3811110_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018820.1\|3811343_3811619_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018812.1\|3793876_3795733_-\|hypothetical-protein	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|378245
NC_013947.1\|WP_013018821.1\|3813246_3813387_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300813.1\|3796424_3798644_-\|CRISPR-associated-endonuclease-Cas3''	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NC_013947.1\|WP_041625013.1\|3800253_3803565_-\|error-prone-DNA-polymerase	unknown	unknown	gnl\|CDD\|235553
NC_013947.1\|WP_144300546.1\|3809520_3810030_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018809.1\|3791090_3791405_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300544.1\|3790649_3791054_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018818.1\|3806820_3808026_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NC_013947.1\|WP_144300545.1\|3806052_3806385_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273840
NC_013947.1\|WP_041626467.1\|3788913_3789345_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|223149
NC_013947.1\|WP_013018813.1\|3795732_3796428_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl\|CDD\|187782
NC_013947.1\|WP_013018817.1\|3806446_3806824_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018810.1\|3791580_3791913_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013018822.1\|3813476_3816314_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	7.12074e-18
NC_013947.1\|WP_144300813.1\|3796424_3798644_-\|CRISPR-associated-endonuclease-Cas3''	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	3.35555e-47
NC_013947.1\|WP_041625013.1\|3800253_3803565_-\|error-prone-DNA-polymerase	gnl\|CDD\|235553	PRK05672, dnaE2, error-prone DNA polymerase; Validated.	0
NC_013947.1\|WP_041626467.1\|3788913_3789345_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	6.2955e-26
NC_013947.1\|WP_013018805.1\|3786079_3788824_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	6.84879e-39
NC_013947.1\|WP_013018818.1\|3806820_3808026_-\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	3.21688e-09
NC_013947.1\|WP_144300545.1\|3806052_3806385_-\|hypothetical-protein	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	0.000108567
NC_013947.1\|WP_144300812.1\|3790042_3790285_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133379	cd01104, HTH_MlrA-CarA, Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA. Helix-turn-helix (HTH) transcription regulator MlrA (merR-like regulator A), N-terminal domain. The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. Its close homolog, CarA from Myxococcus xanthus, is involved in activation of the carotenoid biosynthesis genes by light. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA- and CarA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins.	5.4619e-06
NC_013947.1\|WP_013018811.1\|3793002_3793884_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	3.38144e-123
NC_013947.1\|WP_013018813.1\|3795732_3796428_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187782	cd09651, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	1.78597e-76
NC_013947.1\|WP_013018812.1\|3793876_3795733_-\|hypothetical-protein	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	9.55879e-101

>NC_013947.1|WP_144300813.1|3796424_3798644_-|CRISPR-associated-endonuclease-Cas3''
MRGVAVLARRFAGEFGVGDLGYLTGLWHDAGKASCAWQDGLVRAEASGGPVGVDHKTLGCELAAEHGLQALGLVLHGHHGGLTSPGFVADALKNLSEAQRRNNAEARRGLTDLLAETGWARDVVLPWAKPLVAEMGLRLVFSALCDADSLDTAMHREGLAAPLVARDADVGLLWDRFQQRREDLLRHRPMSAVNVARQALFDECLRAAGKPRGMFRIPAATGLGKTINAGAFAMRHAAIHGMRRVVVAVPWLTITEQNAAVYRGLLDEGDEQVVLEHHSGVDFDVLPDCRRWERLASENWDAPFVVTTTVRLFESLFGRKREATRRLHRLSNAVVVLDEVQGLPYRLLLPILDGLRTLVDHFGASVVLCSATQPDFWNLGPFQGMEACDIVVPQELTRAVDGRVRYEWWTDPQPMLSDVADRACADESALVVVNTTKDASAVVDRWRELAGDSLVYHLSTRMCPAHRRYVLAAVRSGLAAGTPVLLVSTQLIEAGVDVDFAVVYRALAPADSLVQAGGRANREGRLPDGGRVVIFDPLDGGAPPTYRTLVGNTRRFFGPDKSAPDDTTAQLRYWRAVYDDTGVEGRGSIGRQIQSARQRLDYQSVTDGPQDLETGARDSKLAFRMISDDSVAVICPQWVGNGDGRGTGEKNLVSNEFNPRVLELIDQVRSGIGIGSAMRQLQPFTTNLHISAVRKPGVTALLAPLLGDVDTPGSLAVWQGDYDVTTGIALDPEMERFVL
>NC_013947.1|WP_013018813.1|3795732_3796428_-|type-I-C-CRISPR-associated-protein-Cas5
MTPHGTAITLPTDPHGHRPVAVQVWGDAALFTRPELKAERLTYPVMTPSAAKGVLEAIYWKPEMAYQVVAIEVLKPIKQFTVRRNETNDVASLRDAAKGVRRIDTAAKRDQRNAVCLRDVAYRIHAHIRLQPHANKPVVAYRDQFRRRVDKGACFAQPYLGTREFTAYFGKPDGTPARDELDGDLGIMIHTVGYDGDHAMEWFTARLDRGVLRVPERGIVAEASHISAAVG
>NC_013947.1|WP_013018812.1|3793876_3795733_-|hypothetical-protein
MLLQRLAQFAAQRETDENPIPAFYIEKPVRWVLRLHADGTPETLDMTDRADPSDTARRFGTPMAVPSVTKTSAPAPTPGVDTVEYVFGWVTTDPKANVKPDKVVKRHKAFIALNERWARDDPDSPASAIAAFYRDGHHRTIMEPMRINGRGEELQRVPAWSRGDLVCFEIDGAKAAASTSAQRFWASIAAERKGSGTSGLCLVCGEWAELLKTVPQQLPQRLVPGATQSASLVSVNKPTHGFDLTTELRHTPICQGCGLRVMSGLGMLLDDKQHSTGSGDSRMAWWTIGGEQVSLDMLLHPHQHLDDVHHLITAARTGHRHSVKDIDTGRFCSVIVGGNVSRIMVRDWVEQPLTQVQANLGRWFNDITTTDGDNTRLPGVGLLALACGRYDPKLTAESGGYLGFNKPGADRPDGVYRSLLQAALYGRRLPPGLSKHIIHRIRRDGYLDPARAALLHVGRIRQATTNDQKEPMEITTSSTEEPAKVAGQIFAMYEYLQWAATNPTPNKTTGRAERVNTSFTDRHFSGAITNPRRALTAGARISQAWLKRVRRDNPARAEWIDRQLTELYEHLNQAGGPPSTALLSQQSDFILGYYQQRQQRFANRSANNTTTETESNDE
>NC_013947.1|WP_013018811.1|3793002_3793884_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSEAHLDPTMRHDAVLLFDVTDGNPNGDPDAANQPRMDDETGQGIVTDVAIKRKIRDTVSLLKGDDPRFGIFVEAGHALNTRIAQALKESADDSDNARQWICDHYFDVRMFGAVLSTGDKIPGSKKRGAGQVYGPTQLTFARSIDAISPVEHTITRVTQTKQADIDAGESTELGAKWTVPYGLYRTHLHYSAPKATKTGVTADDLHTLWKAIQFMFEHNHSAARGEMKLCGLYVFSHSSAVGDAPAHQLFNTIAISPLEADKPPRHHTDYRRQFEKASVPSRITSTVLTDLWP
>NC_013947.1|WP_013018810.1|3791580_3791913_+|hypothetical-protein
MTVHALHRAADLIEQRGWTRGGYCYPDAEGYCMDKALLAVCGLCTACENKHDLTDEYRDALAALRAALNVATCWDLWWWNDNSRRTKSDVVRLLRRAADHAPARRKSLTQ
>NC_013947.1|WP_013018809.1|3791090_3791405_+|hypothetical-protein
MAMPTPSSAIGFHTQAQWITMLEQTLASAQRQRSARAGLDSCGVPEWVAFERRAMHEAVNRARVDRGLSPVTEAHVRWAEERAVGHGDYTRKFALYCADLISSE
>NC_013947.1|WP_144300544.1|3790649_3791054_+|hypothetical-protein
MPSASESDPAVISYQQRPCRECPWKKEAPVGKFPPEAFQHTADTAVQPDLSAWAGQGPLQKVFACHMSGSEDHDTKACAGFLAVEGHANLEVRVRVARGEIAAEALAPGEDWPELYASHDDMARANGLDIVDSC
>NC_013947.1|WP_144300812.1|3790042_3790285_+|MerR-family-transcriptional-regulator
MLTVQQAFLRSLDAADIITPQRSPGGHRRYSRRQVTLIVRLREQLDEGHTLAAAVRITDLQDQLEQAHTEISRLRNQPRQ
>NC_013947.1|WP_041626467.1|3788913_3789345_-|Hsp20/alpha-crystallin-family-protein
MLMRTDPFRELDRLAQQMLGVNGTASRPAAMPMDAYRTADDYVVRFDLPGVDAESIDLDVERNVLTVKAERRPDFGENDDVEVAERPRGVFSRQLFLGDTLDTDNINADYTNGVLTLHIPVAEQAKPRKIAIGSTTQRKQINA
>NC_013947.1|WP_013018805.1|3786079_3788824_+|LuxR-family-transcriptional-regulator
MDTPGLGPISKREAEVLAVLGEHLTNAQIAHRLHISVRTVENHVSSLLRKLGAANRQALAAIAGPRPDAPSPGTVIGIPHGHTTFVGRRPDHDAVVTALADARLVSLMGPGGMGKTRLAAVVATAVAPAFPAGAAFVDLVPVRPGQVTVAVAQVLGVTERPPQTLDHTIVGWLKQGRFLLVLDNCEHVVDDVAALAAMVQQRCPNTTILATTRRRLAVPGEQVVRLGPLPIEPDAVRLFFDRARAVDAELDIDPQTAAAICRNLDGMPLAVEIAAARAASLGAEGLRAAAGDRLRLASGTRGVHPRHSSLSAVMSWSYDLLDTEAQAALRALSVFTGSFDLSAVAAATASTHDSAVADVIGRLADDSLVVRDGRFGRGRWRLLDTVRAFAAQRRDPAEHSRVRERYIAWAAQTAARLAAELGDDEQLDFAAVAADLRAAAASTAASPDPTAHRLAVSLATVTFAYGFNREAREHFTGAAQRAPDARQAGRDLCAAANVATAVYDGPAAFDLFLAAANRSRAAGLDNDAAAATASALITALRFPGEFPQRLTPEDGARLLATAMRDATQDDPRTAALIAAARAWNDGTGADEALELARALGDPLLLLGALDIAMTDPGRRAQVGEFVAERLRLVAELPRHDPAAATEITDTFHVATSHAVATGDLPAAASILETAAAQDPLAGHPYVTAPRRIRVAVLAGRFGEALAATEALWDEWQRDGAPTRRWMATAVAMAALAEGLRGTSHSHRWRERALRVAQTDDVTGSIELAACIAFVDARLAVHTGHTVDAGAMVKRAFASFKDETVVPHPAVGGHIWKSYARAAAAELAVFAGLPDAGELLTAASHHAADNRWAAACLARARGRLTGEPEHLASVAAQWDRIGARFERACTLMLIPEHRDEARTELEALGASSPAL
>NC_013947.1|WP_041625013.1|3800253_3803565_-|error-prone-DNA-polymerase
MTEGWGGRGRHLTWRQLRDRMVGRATSGSGVGKPRHLRLVTDDEPTPPASSPPAVEAGGYAELHAHSNFSFLDGASSPEDLVAEALRLGLSGLAITDHDGLYGAVRFAQAAKGTGLATVYGAELSIGLTGERAGVPDPSGTHLLVLARGAEGYAKLSAAIGNAHLAGGQKGLPDYGSLEGVAARLRGHVVVLTGCRKGPVRRALDAGGVDAARVELERLVELFGRDGVYVELTDHQAFTDGDRNEALADLASELGLSVVATNNVHYARSSRHRLSQVAAAVRANMPLDELDGWLPAAPTARLCSPDEMVERFAPFGGAVASSLRLARELAFDLDLVAPALPPFPVPAGHDEDSWLRHLVQAGAAERYGPLGSRSDVVRQLDHELDVIKRLGFAGYFLIVHDIVDYCRREGILVQGRGSAANSVVCFTLGITAADPIAFKLLFERFLSPAREGPPDIDLDIEARRREAVIQYVYDTYGRTYAAQVANVITYRRRSAIRDSAAALGYSPGQVDAWIAASPRRGGPALTELPADVGTYAGQLLGAPRHLGIHSGGMVICDRPIIDVVPVEHARMDKRTVLQWDKDDCADAGLVKIDLLGLGMLTALREARDVANAHYDVPVDLAALTPDDAEVYAMVHKGDAIGTFQIESRAQLQLAPRLRPANLHDLAVQIALVRPGPIQGGAVHPYLRRRDGLEPVVYPHRLAQPALEKSLGVPLFQEQMMQLAVDCGGFSPADADELRQAMGAKRSAERMHRLKDRFYAGAAANDIPHATIDDLWSRMEAFSGYGFPESHAISFAYIAYASCYLKRYYPAAFLTGLIRAQPMGFYSINTLIADARRHGVRIHPVHINHSHATTTLDGHGTPAPADAPARQWGSGGPAVRLGLNQVHGISDTVAERIAVGQPYTSITDLARRAGLTETHLENLATAGALTALGPTRRQALWMAAPAAANTHDTIDGTIQLTAPMLPGMSNAELTAADLTATGSSVDSHPIEHIRHQLDAHDATPIDQLATLPDRTRVVVGGIVTHRQAPETAGGILFINLEDETGQANIVCEPGLRLAYPREAHATPVLLIRGQLRNAGGVTSITADKLTPLHTPMPTKPRNFR
>NC_013947.1|WP_169313894.1|3803704_3804400_-|hypothetical-protein
MSAAQSPPSPHHAPGSPPGPGMRPPGVTPPVAPGRNIGLIVGLVIAGVAVLLAGVGVAVAVWPQEADSAALVAAGRDNVYGTTSTPCDLVDQQELADLVGFEGAKYDEETYGPDDDFDYNGMLCQLSTQVSDVTEYPLFELRAESHADTASADSAFEERVAEIGIEESVGLEQTMLLLKPNGSSPACLIMRNGNLVLTMELDSNYLDIPEDAAGDFLTDSAKKVMAALKDT
>NC_013947.1|WP_144300545.1|3806052_3806385_-|hypothetical-protein
MWTVGRSDEVLLDKDSSGELGQADCGGIITGELVSVYDGTTVNRSSQLDIDDFVPLAETWDSGASQWSTHRRKTYATYLDDHRHLVAVTASSNRSKGDQDPAEWMPSMQQ
>NC_013947.1|WP_013018817.1|3806446_3806824_-|hypothetical-protein
MNDATTHSVSVIVSRDHHRWAAEAPSISMWTFGRTLSQIHQHVTDAAALALDIHPEHVAVTLTVVSPELEELTRARAREQAALTAAVRRLRSQKVSWPETARILHVSQHEARAAVATASVEDNQR
>NC_013947.1|WP_013018818.1|3806820_3808026_-|recombinase-family-protein
MTSAPIDLSTLPGYSWDTSTRAHITAFLGRCSTKDQQDPTTSIPGQATVCARRLGQGEDFAAYFWDVESGYMHLNARSQHDDDYYAELAVPLRRDGGLTDLLAAAHAGEITRVICERSDRAARDMLTILTVESHLEQWGVELVYATEPPPQRPGDMPASRLRMRRGQQMDAEIYRALMLENSERGQREHAAQGYSHGPAPYPYIAVIDPDAPARHDRYIRRPKRRLQPHPGPHRWDTSVHMARLRLEDARYRDIRIALNADPEKYPHDKPGGQWTDRRIRSLLLNPRLTGYAVFNRRSSKNGFTPIPMQEWTWSRQPSHKAVFTVDEWVQMVRMDAADRAPRDALERVRAAAHQHGYLLREVRSNDTHIVYAIGSREFTVPHGVLPEPAAEHIITWLETAA
>NC_013947.1|WP_144300546.1|3809520_3810030_-|hypothetical-protein
MNETTTAAATMSIRCLVMSGKHEKGKRHLRSAMNVTPMCRMPLGIVRRCQQMLTPLPRTHVRVMHQAISPHGGNREEPDWPHPVTQPTSTVPQLKRKWETRPKGKKNCNRLPKFVAQSSDVITGQQAYHSVVQYRPFESGRDDLDFAGDLIENGGDEFAKKLSKNDLPR
>NC_013947.1|WP_144300547.1|3810153_3811110_+|helix-turn-helix-domain-containing-protein
MATKDPVIDRVGLVEEFAAQLDKLRRQAGGLTFRQMAAQIQGTVAASTLCRAVNGKKLPAWRVVQLFVEACGGDVEHWRTQHIRVSNALRSGAAQDVDSSTAPPSRVSDQRKMPTVQEALFRGAIRNMDRALIELDAVVDDPLTASIRIPGGHLGDQVHLLRQLWAVLNHRRRPVDSPASFAQCMKELKEHAGLSLLQISRQTDPSHMSKKARQDLGLDVSKPIAVSTLSDLCNPHQGRLPNAATLDRFLHALGYSAKEREGWQRLRADLAVQYDRRFHRPARAKSSRVKRPSFRPGGDMEIFGSYIDNEGFSLWDPY
>NC_013947.1|WP_013018820.1|3811343_3811619_-|hypothetical-protein
MANPVTDPDVSNTSGPARFATVLVNDPGRFKKLSFSRQLVRVNGFVGIVKRLQVSIVFIMVRVNGIMVTLMAFTVTIGGAARVSPSFEGTS
>NC_013947.1|WP_013018821.1|3813246_3813387_-|hypothetical-protein
MTGVRVMPVKLRWGDIALLGLIAAAIVRIGLTITLVSTRGRVGDPD
>NC_013947.1|WP_013018822.1|3813476_3816314_-|sigma-70-family-RNA-polymerase-sigma-factor
MTSTTAMIRIEPLVRWPRHMTSGQAHLVEVDLRLLDEHWPYENEEFTFHVLLAGMPFHEVRTVGPPEIVVHRFGGSYGSCRFVVTPTVASGDHPLALSLETDGGAHVTTIELPVHVAAETRDEVREAVVPAAGRSGRAEHRANPAVTARSVVPLLAAHIGPDFSTDAVAAVAGVDLPTAGRLLAELAADGSVDESRDARYSLSPKGRGRIETTPADLRDAARRRLLDHYRQTGQLALEIMAPRGVSVVQGVIGFRDRSAARDWLDEETSNMAAYASLAAENGWMEHARELLQVLSQHLLDTGHHETFFRLCRRMANASDHEVKDLALNELADTYLELGRYLEAMECLNRVRELEASSAGIAGHAEALNKLGVVHSRLGQHERAYEFHQRALEFARGTENRLLIVDTCVQLGISLVSQGRLQEALARFAHARDLSEELNDQYRVALSTEHLAQVHAALGNVDNGRELWAEAAQRYRSLARPPTDTSRSDTEPVPGVAGRVSDERRLTEAIEQLASGRRAEQDVGIQTLETLARQVKQLRQTAVDELCRYVREFSERETNTAKSSHHGRVRHVLDILVDLSHATDANVEPTNIDLSGAVLPQVDFTDCRFGYASFNRAVFTRQANFTNVVFDGPAQFSDTMFEFPDAGSAVFTSAKFQGAADFSRAEFNGRASFLSVSFLDEVIFRDANFMAAALFTGGSGHGAVRFDDVIIAEPESLRLEDFEVLQPSAAHRWPVGWSPYTTANEGLSLRRAPEAGVSRADERLALALAHMGEPDALDEVIAEYSPLVWRVARGQGLDRSMAEDVVQATWMRLVQSLPRDVQNLKNLQGWLTSSAKREAWKRARQARLEIPSSLEWFEDLRSSENVEDDVADRMNTAPRYQAIWAALNQMSDVCRALIQVIAYTDRPDYDAVARQLGIARGSIGPTRGRCLAHLRRLLQENSDFND

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Crispr_ID: NC_013947_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_9

3804987-3805735

TypeI

Consensus_repeat	Method
GTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAACC	CRISPRCasFinder
GTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAAC	CRT
CTCCAGCGAGGATCGCAAC	PILER-CR

10 spacers

cas3,cas5,cas8c,cas7b

The CRISPR arrays of NC_013947_9

>merge|NC_013947|9|3804987-3805735|CRISPRCasFinder,CRT,PILER-CR
GTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAACAGCAGCTGCAAGCCTATGCGCTGCACCTGGAGGCGTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAACCTCGTCGACCCCGACACTGGCGCCCGCCGGATCCTGGTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAACCATGGCGACGTCGAAACGCACCCACCGGCGGCGTGTGGCGCTGGAGCACCAGCTCCAGCTCCAGCTCCAGCTCCAGCTCCCGCTCCCGCTCCCGCTCCCGCTCCCGCTCCCGCTCCAGCGAGGATCGCAACATCGCTTCGGTTCCCGGATTTGACACTGAGTCGGATGTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAACGTGTGGTTCCCCGAATGATGGGGACCTGGATGACCGTGGCGCTGGAGCACCCACTCCAGCGAGGATCGCAACAACCGCCGCGTCTGCGGTATCCACACCGGTTGGGAGTGGCGCTGGAGCACCCACTCCAGCGAGGATCGCAACGGTGTTGGGCCGTACCCGCCCGACCGCGCGGATCGCGTGGCGCTGGAGCACCACCTCCAGCGAGGATCGCAACTGCGACAGACTGCCGAGCCCTTTGGACAGTTGGCCCGTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAACATCATCCTGATCACGTGCGAAGTCCAGGCCCTCATTGTGGCGCTGGAGCATCCGCCCCAGCGAGGATCGCAACA

>NC_013947|9|8|3804987-3805735|CRISPRCasFinder
GTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAACA	GCAGCTGCAAGCCTATGCGCTGCACCTGGAGGC
GTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAACC	TCGTCGACCCCGACACTGGCGCCCGCCGGATCCTG
GTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAACC	ATGGCGACGTCGAAACGCACCCACCGGCGGCGT
GTGGCGCTGGAGCACCAGCTCCAGCTCCAGCTCCAGCT	CCAGCTCCCGCTCCCGCTCCCGCTCCCGCTCCCGCTCCCGCTCCAGCGAGGATCGCAACATCGCTTCGGTTCCCGGATTTGACACTGAGTCGGAT
GTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAACG	TGTGGTTCCCCGAATGATGGGGACCTGGATGACC
GTGGCGCTGGAGCACCCACTCCAGCGAGGATCGCAACA	ACCGCCGCGTCTGCGGTATCCACACCGGTTGGGA
GTGGCGCTGGAGCACCCACTCCAGCGAGGATCGCAACG	GTGTTGGGCCGTACCCGCCCGACCGCGCGGATCGC
GTGGCGCTGGAGCACCACCTCCAGCGAGGATCGCAACT	GCGACAGACTGCCGAGCCCTTTGGACAGTTGGCCC
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAACA	TCATCCTGATCACGTGCGAAGTCCAGGCCCTCATT
GTGGCGCTGGAGCATCCGCCCCAGCGAGGATCGCAACA

>NC_013947|9|3|3804987-3805238|CRT
GTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAAC	AGCAGCTGCAAGCCTATGCGCTGCACCTGGAGGC
GTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAAC	CTCGTCGACCCCGACACTGGCGCCCGCCGGATCCTG
GTGGCGCTGGAGCACCAGCTCCAGCGAGGATCGCAAC	CATGGCGACGTCGAAACGCACCCACCGGCGGCGT
GTGGCGCTGGAGCACCAGCTCCAGCTCCAGCTCCAGC

>NC_013947|9|2|3805005-3805734|PILER-CR
CTCCAGCGAGGATCGCAAC	AGCAGCTGCAAGCCTATGCGCTGCACCTGGAGGCGTGGCGCTGGAGCACCAG
CTCCAGCGAGGATCGCAAC	CTCGTCGACCCCGACACTGGCGCCCGCCGGATCCTGGTGGCGCTGGAGCACCAG
CTCCAGCGAGGATCGCAAC	CATGGCGACGTCGAAACGCACCCACCGGCGGCGTGTGGCGCTGGAGCACCAG
CTCCAGCTCCAGCTCCAGC	TCCAGCTCCCGCTCCCGCTCCCGCTCCCGCTCCCGCTCCCGCTCCAGCGAGGA
TCGCAACATCGCTTCGGTT	CCCGGATTTGACACTGAGTCGGATGTGGCGCTGGAGCACCAGCTCCAGCGAGGA
TCGCAACGTGTGGTTCCCC	GAATGATGGGGACCTGGATGACCGTGGCGCTGGAGCACCCACTCCAGCGAGGA
TCGCAACAACCGCCGCGTC	TGCGGTATCCACACCGGTTGGGAGTGGCGCTGGAGCACCCACTCCAGCGAGGA
TCGCAACGGTGTTGGGCCG	TACCCGCCCGACCGCGCGGATCGCGTGGCGCTGGAGCACCACCTCCAGCGAGGA
TCGCAACTGCGACAGACTG	CCGAGCCCTTTGGACAGTTGGCCCGTGGCGCTGGAGCATCCGCTCCAGCGAGGA
TCGCAACATCATCCTGATC	ACGTGCGAAGTCCAGGCCCTCATTGTGGCGCTGGAGCATCCGCCCCAGCGAGGA
TCGCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013018821.1\|3813246_3813387_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018820.1\|3811343_3811619_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018823.1\|3816310_3817570_-\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378942
NC_013947.1\|WP_169313894.1\|3803704_3804400_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018824.1\|3817562_3819284_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273935
NC_013947.1\|WP_144300812.1\|3790042_3790285_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133379
NC_013947.1\|WP_144300547.1\|3810153_3811110_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018812.1\|3793876_3795733_-\|hypothetical-protein	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|378245
NC_013947.1\|WP_013018822.1\|3813476_3816314_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_013947.1\|WP_144300813.1\|3796424_3798644_-\|CRISPR-associated-endonuclease-Cas3''	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NC_013947.1\|WP_041625013.1\|3800253_3803565_-\|error-prone-DNA-polymerase	unknown	unknown	gnl\|CDD\|235553
NC_013947.1\|WP_144300546.1\|3809520_3810030_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018809.1\|3791090_3791405_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300544.1\|3790649_3791054_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018818.1\|3806820_3808026_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NC_013947.1\|WP_144300545.1\|3806052_3806385_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273840
NC_013947.1\|WP_013018811.1\|3793002_3793884_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_013947.1\|WP_013018813.1\|3795732_3796428_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl\|CDD\|187782
NC_013947.1\|WP_013018817.1\|3806446_3806824_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018810.1\|3791580_3791913_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013018822.1\|3813476_3816314_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	7.12074e-18
NC_013947.1\|WP_144300813.1\|3796424_3798644_-\|CRISPR-associated-endonuclease-Cas3''	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	3.35555e-47
NC_013947.1\|WP_041625013.1\|3800253_3803565_-\|error-prone-DNA-polymerase	gnl\|CDD\|235553	PRK05672, dnaE2, error-prone DNA polymerase; Validated.	0
NC_013947.1\|WP_013018818.1\|3806820_3808026_-\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	3.21688e-09
NC_013947.1\|WP_144300545.1\|3806052_3806385_-\|hypothetical-protein	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	0.000108567
NC_013947.1\|WP_013018824.1\|3817562_3819284_-\|hypothetical-protein	gnl\|CDD\|273935	TIGR02031, Magnesium-chelatase_67_kDa_subunit, magnesium chelatase ATPase subunit D. This model represents one of two ATPase subunits of the trimeric magnesium chelatase responsible for insertion of magnesium ion into protoporphyrin IX. This is an essential step in the biosynthesis of both chlorophyll and bacteriochlorophyll. This subunit is found in green plants, photosynthetic algae, cyanobacteria and other photosynthetic bacteria. Unlike subunit I (TIGR02030), this subunit is not found in archaea. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll].	1.54567e-15
NC_013947.1\|WP_144300812.1\|3790042_3790285_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133379	cd01104, HTH_MlrA-CarA, Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA. Helix-turn-helix (HTH) transcription regulator MlrA (merR-like regulator A), N-terminal domain. The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. Its close homolog, CarA from Myxococcus xanthus, is involved in activation of the carotenoid biosynthesis genes by light. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA- and CarA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins.	5.4619e-06
NC_013947.1\|WP_013018811.1\|3793002_3793884_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	3.38144e-123
NC_013947.1\|WP_013018813.1\|3795732_3796428_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187782	cd09651, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	1.78597e-76
NC_013947.1\|WP_013018812.1\|3793876_3795733_-\|hypothetical-protein	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	9.55879e-101
NC_013947.1\|WP_013018823.1\|3816310_3817570_-\|CHAT-domain-containing-protein	gnl\|CDD\|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	1.32168e-05

>NC_013947.1|WP_169313894.1|3803704_3804400_-|hypothetical-protein
MSAAQSPPSPHHAPGSPPGPGMRPPGVTPPVAPGRNIGLIVGLVIAGVAVLLAGVGVAVAVWPQEADSAALVAAGRDNVYGTTSTPCDLVDQQELADLVGFEGAKYDEETYGPDDDFDYNGMLCQLSTQVSDVTEYPLFELRAESHADTASADSAFEERVAEIGIEESVGLEQTMLLLKPNGSSPACLIMRNGNLVLTMELDSNYLDIPEDAAGDFLTDSAKKVMAALKDT
>NC_013947.1|WP_041625013.1|3800253_3803565_-|error-prone-DNA-polymerase
MTEGWGGRGRHLTWRQLRDRMVGRATSGSGVGKPRHLRLVTDDEPTPPASSPPAVEAGGYAELHAHSNFSFLDGASSPEDLVAEALRLGLSGLAITDHDGLYGAVRFAQAAKGTGLATVYGAELSIGLTGERAGVPDPSGTHLLVLARGAEGYAKLSAAIGNAHLAGGQKGLPDYGSLEGVAARLRGHVVVLTGCRKGPVRRALDAGGVDAARVELERLVELFGRDGVYVELTDHQAFTDGDRNEALADLASELGLSVVATNNVHYARSSRHRLSQVAAAVRANMPLDELDGWLPAAPTARLCSPDEMVERFAPFGGAVASSLRLARELAFDLDLVAPALPPFPVPAGHDEDSWLRHLVQAGAAERYGPLGSRSDVVRQLDHELDVIKRLGFAGYFLIVHDIVDYCRREGILVQGRGSAANSVVCFTLGITAADPIAFKLLFERFLSPAREGPPDIDLDIEARRREAVIQYVYDTYGRTYAAQVANVITYRRRSAIRDSAAALGYSPGQVDAWIAASPRRGGPALTELPADVGTYAGQLLGAPRHLGIHSGGMVICDRPIIDVVPVEHARMDKRTVLQWDKDDCADAGLVKIDLLGLGMLTALREARDVANAHYDVPVDLAALTPDDAEVYAMVHKGDAIGTFQIESRAQLQLAPRLRPANLHDLAVQIALVRPGPIQGGAVHPYLRRRDGLEPVVYPHRLAQPALEKSLGVPLFQEQMMQLAVDCGGFSPADADELRQAMGAKRSAERMHRLKDRFYAGAAANDIPHATIDDLWSRMEAFSGYGFPESHAISFAYIAYASCYLKRYYPAAFLTGLIRAQPMGFYSINTLIADARRHGVRIHPVHINHSHATTTLDGHGTPAPADAPARQWGSGGPAVRLGLNQVHGISDTVAERIAVGQPYTSITDLARRAGLTETHLENLATAGALTALGPTRRQALWMAAPAAANTHDTIDGTIQLTAPMLPGMSNAELTAADLTATGSSVDSHPIEHIRHQLDAHDATPIDQLATLPDRTRVVVGGIVTHRQAPETAGGILFINLEDETGQANIVCEPGLRLAYPREAHATPVLLIRGQLRNAGGVTSITADKLTPLHTPMPTKPRNFR
>NC_013947.1|WP_144300813.1|3796424_3798644_-|CRISPR-associated-endonuclease-Cas3''
MRGVAVLARRFAGEFGVGDLGYLTGLWHDAGKASCAWQDGLVRAEASGGPVGVDHKTLGCELAAEHGLQALGLVLHGHHGGLTSPGFVADALKNLSEAQRRNNAEARRGLTDLLAETGWARDVVLPWAKPLVAEMGLRLVFSALCDADSLDTAMHREGLAAPLVARDADVGLLWDRFQQRREDLLRHRPMSAVNVARQALFDECLRAAGKPRGMFRIPAATGLGKTINAGAFAMRHAAIHGMRRVVVAVPWLTITEQNAAVYRGLLDEGDEQVVLEHHSGVDFDVLPDCRRWERLASENWDAPFVVTTTVRLFESLFGRKREATRRLHRLSNAVVVLDEVQGLPYRLLLPILDGLRTLVDHFGASVVLCSATQPDFWNLGPFQGMEACDIVVPQELTRAVDGRVRYEWWTDPQPMLSDVADRACADESALVVVNTTKDASAVVDRWRELAGDSLVYHLSTRMCPAHRRYVLAAVRSGLAAGTPVLLVSTQLIEAGVDVDFAVVYRALAPADSLVQAGGRANREGRLPDGGRVVIFDPLDGGAPPTYRTLVGNTRRFFGPDKSAPDDTTAQLRYWRAVYDDTGVEGRGSIGRQIQSARQRLDYQSVTDGPQDLETGARDSKLAFRMISDDSVAVICPQWVGNGDGRGTGEKNLVSNEFNPRVLELIDQVRSGIGIGSAMRQLQPFTTNLHISAVRKPGVTALLAPLLGDVDTPGSLAVWQGDYDVTTGIALDPEMERFVL
>NC_013947.1|WP_013018813.1|3795732_3796428_-|type-I-C-CRISPR-associated-protein-Cas5
MTPHGTAITLPTDPHGHRPVAVQVWGDAALFTRPELKAERLTYPVMTPSAAKGVLEAIYWKPEMAYQVVAIEVLKPIKQFTVRRNETNDVASLRDAAKGVRRIDTAAKRDQRNAVCLRDVAYRIHAHIRLQPHANKPVVAYRDQFRRRVDKGACFAQPYLGTREFTAYFGKPDGTPARDELDGDLGIMIHTVGYDGDHAMEWFTARLDRGVLRVPERGIVAEASHISAAVG
>NC_013947.1|WP_013018812.1|3793876_3795733_-|hypothetical-protein
MLLQRLAQFAAQRETDENPIPAFYIEKPVRWVLRLHADGTPETLDMTDRADPSDTARRFGTPMAVPSVTKTSAPAPTPGVDTVEYVFGWVTTDPKANVKPDKVVKRHKAFIALNERWARDDPDSPASAIAAFYRDGHHRTIMEPMRINGRGEELQRVPAWSRGDLVCFEIDGAKAAASTSAQRFWASIAAERKGSGTSGLCLVCGEWAELLKTVPQQLPQRLVPGATQSASLVSVNKPTHGFDLTTELRHTPICQGCGLRVMSGLGMLLDDKQHSTGSGDSRMAWWTIGGEQVSLDMLLHPHQHLDDVHHLITAARTGHRHSVKDIDTGRFCSVIVGGNVSRIMVRDWVEQPLTQVQANLGRWFNDITTTDGDNTRLPGVGLLALACGRYDPKLTAESGGYLGFNKPGADRPDGVYRSLLQAALYGRRLPPGLSKHIIHRIRRDGYLDPARAALLHVGRIRQATTNDQKEPMEITTSSTEEPAKVAGQIFAMYEYLQWAATNPTPNKTTGRAERVNTSFTDRHFSGAITNPRRALTAGARISQAWLKRVRRDNPARAEWIDRQLTELYEHLNQAGGPPSTALLSQQSDFILGYYQQRQQRFANRSANNTTTETESNDE
>NC_013947.1|WP_013018811.1|3793002_3793884_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSEAHLDPTMRHDAVLLFDVTDGNPNGDPDAANQPRMDDETGQGIVTDVAIKRKIRDTVSLLKGDDPRFGIFVEAGHALNTRIAQALKESADDSDNARQWICDHYFDVRMFGAVLSTGDKIPGSKKRGAGQVYGPTQLTFARSIDAISPVEHTITRVTQTKQADIDAGESTELGAKWTVPYGLYRTHLHYSAPKATKTGVTADDLHTLWKAIQFMFEHNHSAARGEMKLCGLYVFSHSSAVGDAPAHQLFNTIAISPLEADKPPRHHTDYRRQFEKASVPSRITSTVLTDLWP
>NC_013947.1|WP_013018810.1|3791580_3791913_+|hypothetical-protein
MTVHALHRAADLIEQRGWTRGGYCYPDAEGYCMDKALLAVCGLCTACENKHDLTDEYRDALAALRAALNVATCWDLWWWNDNSRRTKSDVVRLLRRAADHAPARRKSLTQ
>NC_013947.1|WP_013018809.1|3791090_3791405_+|hypothetical-protein
MAMPTPSSAIGFHTQAQWITMLEQTLASAQRQRSARAGLDSCGVPEWVAFERRAMHEAVNRARVDRGLSPVTEAHVRWAEERAVGHGDYTRKFALYCADLISSE
>NC_013947.1|WP_144300544.1|3790649_3791054_+|hypothetical-protein
MPSASESDPAVISYQQRPCRECPWKKEAPVGKFPPEAFQHTADTAVQPDLSAWAGQGPLQKVFACHMSGSEDHDTKACAGFLAVEGHANLEVRVRVARGEIAAEALAPGEDWPELYASHDDMARANGLDIVDSC
>NC_013947.1|WP_144300812.1|3790042_3790285_+|MerR-family-transcriptional-regulator
MLTVQQAFLRSLDAADIITPQRSPGGHRRYSRRQVTLIVRLREQLDEGHTLAAAVRITDLQDQLEQAHTEISRLRNQPRQ
>NC_013947.1|WP_144300545.1|3806052_3806385_-|hypothetical-protein
MWTVGRSDEVLLDKDSSGELGQADCGGIITGELVSVYDGTTVNRSSQLDIDDFVPLAETWDSGASQWSTHRRKTYATYLDDHRHLVAVTASSNRSKGDQDPAEWMPSMQQ
>NC_013947.1|WP_013018817.1|3806446_3806824_-|hypothetical-protein
MNDATTHSVSVIVSRDHHRWAAEAPSISMWTFGRTLSQIHQHVTDAAALALDIHPEHVAVTLTVVSPELEELTRARAREQAALTAAVRRLRSQKVSWPETARILHVSQHEARAAVATASVEDNQR
>NC_013947.1|WP_013018818.1|3806820_3808026_-|recombinase-family-protein
MTSAPIDLSTLPGYSWDTSTRAHITAFLGRCSTKDQQDPTTSIPGQATVCARRLGQGEDFAAYFWDVESGYMHLNARSQHDDDYYAELAVPLRRDGGLTDLLAAAHAGEITRVICERSDRAARDMLTILTVESHLEQWGVELVYATEPPPQRPGDMPASRLRMRRGQQMDAEIYRALMLENSERGQREHAAQGYSHGPAPYPYIAVIDPDAPARHDRYIRRPKRRLQPHPGPHRWDTSVHMARLRLEDARYRDIRIALNADPEKYPHDKPGGQWTDRRIRSLLLNPRLTGYAVFNRRSSKNGFTPIPMQEWTWSRQPSHKAVFTVDEWVQMVRMDAADRAPRDALERVRAAAHQHGYLLREVRSNDTHIVYAIGSREFTVPHGVLPEPAAEHIITWLETAA
>NC_013947.1|WP_144300546.1|3809520_3810030_-|hypothetical-protein
MNETTTAAATMSIRCLVMSGKHEKGKRHLRSAMNVTPMCRMPLGIVRRCQQMLTPLPRTHVRVMHQAISPHGGNREEPDWPHPVTQPTSTVPQLKRKWETRPKGKKNCNRLPKFVAQSSDVITGQQAYHSVVQYRPFESGRDDLDFAGDLIENGGDEFAKKLSKNDLPR
>NC_013947.1|WP_144300547.1|3810153_3811110_+|helix-turn-helix-domain-containing-protein
MATKDPVIDRVGLVEEFAAQLDKLRRQAGGLTFRQMAAQIQGTVAASTLCRAVNGKKLPAWRVVQLFVEACGGDVEHWRTQHIRVSNALRSGAAQDVDSSTAPPSRVSDQRKMPTVQEALFRGAIRNMDRALIELDAVVDDPLTASIRIPGGHLGDQVHLLRQLWAVLNHRRRPVDSPASFAQCMKELKEHAGLSLLQISRQTDPSHMSKKARQDLGLDVSKPIAVSTLSDLCNPHQGRLPNAATLDRFLHALGYSAKEREGWQRLRADLAVQYDRRFHRPARAKSSRVKRPSFRPGGDMEIFGSYIDNEGFSLWDPY
>NC_013947.1|WP_013018820.1|3811343_3811619_-|hypothetical-protein
MANPVTDPDVSNTSGPARFATVLVNDPGRFKKLSFSRQLVRVNGFVGIVKRLQVSIVFIMVRVNGIMVTLMAFTVTIGGAARVSPSFEGTS
>NC_013947.1|WP_013018821.1|3813246_3813387_-|hypothetical-protein
MTGVRVMPVKLRWGDIALLGLIAAAIVRIGLTITLVSTRGRVGDPD
>NC_013947.1|WP_013018822.1|3813476_3816314_-|sigma-70-family-RNA-polymerase-sigma-factor
MTSTTAMIRIEPLVRWPRHMTSGQAHLVEVDLRLLDEHWPYENEEFTFHVLLAGMPFHEVRTVGPPEIVVHRFGGSYGSCRFVVTPTVASGDHPLALSLETDGGAHVTTIELPVHVAAETRDEVREAVVPAAGRSGRAEHRANPAVTARSVVPLLAAHIGPDFSTDAVAAVAGVDLPTAGRLLAELAADGSVDESRDARYSLSPKGRGRIETTPADLRDAARRRLLDHYRQTGQLALEIMAPRGVSVVQGVIGFRDRSAARDWLDEETSNMAAYASLAAENGWMEHARELLQVLSQHLLDTGHHETFFRLCRRMANASDHEVKDLALNELADTYLELGRYLEAMECLNRVRELEASSAGIAGHAEALNKLGVVHSRLGQHERAYEFHQRALEFARGTENRLLIVDTCVQLGISLVSQGRLQEALARFAHARDLSEELNDQYRVALSTEHLAQVHAALGNVDNGRELWAEAAQRYRSLARPPTDTSRSDTEPVPGVAGRVSDERRLTEAIEQLASGRRAEQDVGIQTLETLARQVKQLRQTAVDELCRYVREFSERETNTAKSSHHGRVRHVLDILVDLSHATDANVEPTNIDLSGAVLPQVDFTDCRFGYASFNRAVFTRQANFTNVVFDGPAQFSDTMFEFPDAGSAVFTSAKFQGAADFSRAEFNGRASFLSVSFLDEVIFRDANFMAAALFTGGSGHGAVRFDDVIIAEPESLRLEDFEVLQPSAAHRWPVGWSPYTTANEGLSLRRAPEAGVSRADERLALALAHMGEPDALDEVIAEYSPLVWRVARGQGLDRSMAEDVVQATWMRLVQSLPRDVQNLKNLQGWLTSSAKREAWKRARQARLEIPSSLEWFEDLRSSENVEDDVADRMNTAPRYQAIWAALNQMSDVCRALIQVIAYTDRPDYDAVARQLGIARGSIGPTRGRCLAHLRRLLQENSDFND
>NC_013947.1|WP_013018823.1|3816310_3817570_-|CHAT-domain-containing-protein
MAERRFPVMSRLLSARRARREPPPDQAHSAEARVPDTGAQAFEPMGAINVDPTASSPAGTVKLRVVRPFGKDEHVEITAKSPGVPKLACIDGAAVREPSTDLSDVIKVGGLAPSEVLARIRNWSLANGAAVTGWLSRARRHCGEEPRLLIHDETDANIPWELLWLPDDPDRRQGAYVGCSFVTARWTPLQVTRREQRNHPYSTLRCRGEVLAYVGEDMAEADLSMIDGYGARTVASARLLFKELADPGRPLSLVYIGAHGRFSTRSFEFTVAEVALGRIFAETFPRIDDAAPLVFLNACHSGRVIIDESDTSLPSSFAEVFLRSGAAGFIGTTGAVREREARQVAKGILNALARQPGKPVATALRDFRRQVVAEHSRQTWSADRGDEESRALPLLYTFMYVYYGSLWTTVELSGRGVGE
>NC_013947.1|WP_013018824.1|3817562_3819284_-|hypothetical-protein
MERMATALACAAIDRHLAGVLLFNLDPGRIGALGRWLAALLGSQTRTVLAGAATHDEDLWTRFSLSGSQVSITPGALFDQTVVLVPDLTQLSDAGARAAIATIGADVAHIERDGHQSIQVPKARWLVGCRREGAGELSRHLLDRFALRVDAADVPGELDPPPRSWRDAVERAAHATPLPMSTRVLGYVMELFTAADAGARRPVAVARLARAIARLDGDETVSVRHVDLATEHLGIPRHHRLSVVDDASPLSRNDAAGPAPNRTEEAIQAPEGPVPQYLAAGAGFEAPSAVHTSLVAVPYPEDEPMTRSRLGSVNLDHTSPQWSNVAAHGRPWGTVPAHDLTDLSITASLLEACKLQVMRCPGHHGSAHRLHVTAADLRRHKRTIQPTDLLVLLVDHTCGGANWNLPAALGAHIAWAYEQRAHIRVVELGDADSADELSARQFVVRNALDRRLHRVLSRRPGRATPLAHGIELAGRVLRRFAGSDRSVARDTRFVLVTDGRGNVPLSASLTGQVDFPVARRGVEDSLYAARQIRTLPRTQTIVVCPGSHRTSPVVTELAQVLGADILTGDGDNG

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Crispr_ID: NC_013947_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_10

3808599-3809352

TypeI

Consensus_repeat	Method
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	PILER-CR
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	CRISPRCasFinder
GTGGCGCTGGAGCATCNGCTCCAGCGAGGATCGCAAC	CRT

10 spacers

cas3,cas5,cas8c,cas7b

The CRISPR arrays of NC_013947_10

>merge|NC_013947|10|3808599-3809352|PILER-CR,CRISPRCasFinder,CRT
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAACTTGGTGATGACGTGATGCTGGCTGGCCATCTCCACGTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAACGGCCGAAACGATGGGTCAGCAGAACGTCGAGGACCGGTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAACGGGACCGCGTCGAGGTCGAGGCGGCGCATCGTGCGTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAACTTCGCGTCGGCGGCGCCAACAGCGATCAGCGCGCGCGTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAACCGGCACTGCTGCACTGGTCCGGCCCGGCCGTCGTGGTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAACGAGTAATACGCCACGATGACCGCCGACACGTACGTGTGGCGCTGGAGCATCCGCTCCAGCGAGAATCGCAACGCGAACTGGTGCGAACACCCCTGTGTCAACGACAGGTGGCGCTGGAGCATCTGCTCCAGCGAGGATCGCAACCGTTGGAATCACCAGGGCTGCCCCGTGTCACTGCCCGTGGCGCTGGAGCATCTGCTCCAGCGAGGATCGCAACGCGTTCGACATGCGCGGCAATCAGTTCGAATGGACCGTGGCGCTGGAGCACTAGCTCCAACCAGGATCGCAACTTGCTCATCAGATCCGCCGCGTACGCTGCCCGCGCGTGGAGCTCCAGTTCCAGCGAGGATCGCAGC

>NC_013947|10|3|3808599-3809140|PILER-CR
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	TTGGTGATGACGTGATGCTGGCTGGCCATCTCCAC
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	GGCCGAAACGATGGGTCAGCAGAACGTCGAGGACCG
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	GGGACCGCGTCGAGGTCGAGGCGGCGCATCGTGC
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	TTCGCGTCGGCGGCGCCAACAGCGATCAGCGCGCGC
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	CGGCACTGCTGCACTGGTCCGGCCCGGCCGTCGTG
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	GAGTAATACGCCACGATGACCGCCGACACGTACGT
GTGGCGCTGGAGCATCCGCTCCAGCGAGAATCGCAAC	GCGAACTGGTGCGAACACCCCTGTGTCAACGACAG
GTGGCGCTGGAGCATCTGCTCCAGCGAGGATCGCAAC

>NC_013947|10|9|3808599-3809352|CRISPRCasFinder
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	TTGGTGATGACGTGATGCTGGCTGGCCATCTCCAC
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	GGCCGAAACGATGGGTCAGCAGAACGTCGAGGACCG
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	GGGACCGCGTCGAGGTCGAGGCGGCGCATCGTGC
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	TTCGCGTCGGCGGCGCCAACAGCGATCAGCGCGCGC
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	CGGCACTGCTGCACTGGTCCGGCCCGGCCGTCGTG
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	GAGTAATACGCCACGATGACCGCCGACACGTACGT
GTGGCGCTGGAGCATCCGCTCCAGCGAGAATCGCAAC	GCGAACTGGTGCGAACACCCCTGTGTCAACGACAG
GTGGCGCTGGAGCATCTGCTCCAGCGAGGATCGCAAC	CGTTGGAATCACCAGGGCTGCCCCGTGTCACTGCCC
GTGGCGCTGGAGCATCTGCTCCAGCGAGGATCGCAAC	GCGTTCGACATGCGCGGCAATCAGTTCGAATGGACC
GTGGCGCTGGAGCACTAGCTCCAACCAGGATCGCAAC	TTGCTCATCAGATCCGCCGCGTACGCTGC
CCGCGCGTGGAGCTCCAGTTCCAGCGAGGATCGCAGC

>NC_013947|10|4|3808599-3809352|CRT
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	TTGGTGATGACGTGATGCTGGCTGGCCATCTCCAC
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	GGCCGAAACGATGGGTCAGCAGAACGTCGAGGACCG
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	GGGACCGCGTCGAGGTCGAGGCGGCGCATCGTGC
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	TTCGCGTCGGCGGCGCCAACAGCGATCAGCGCGCGC
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	CGGCACTGCTGCACTGGTCCGGCCCGGCCGTCGTG
GTGGCGCTGGAGCATCCGCTCCAGCGAGGATCGCAAC	GAGTAATACGCCACGATGACCGCCGACACGTACGT
GTGGCGCTGGAGCATCCGCTCCAGCGAGAATCGCAAC	GCGAACTGGTGCGAACACCCCTGTGTCAACGACAG
GTGGCGCTGGAGCATCTGCTCCAGCGAGGATCGCAAC	CGTTGGAATCACCAGGGCTGCCCCGTGTCACTGCCC
GTGGCGCTGGAGCATCTGCTCCAGCGAGGATCGCAAC	GCGTTCGACATGCGCGGCAATCAGTTCGAATGGACC
GTGGCGCTGGAGCACTAGCTCCAACCAGGATCGCAAC	TTGCTCATCAGATCCGCCGCGTACGCTGC
CCGCGCGTGGAGCTCCAGTTCCAGCGAGGATCGCAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_144300548.1\|3820209_3820572_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018821.1\|3813246_3813387_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018820.1\|3811343_3811619_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018823.1\|3816310_3817570_-\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378942
NC_013947.1\|WP_013018824.1\|3817562_3819284_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273935
NC_013947.1\|WP_169313894.1\|3803704_3804400_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300547.1\|3810153_3811110_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	unknown
NC_013947.1\|WP_041625016.1\|3820615_3820819_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018812.1\|3793876_3795733_-\|hypothetical-protein	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|378245
NC_013947.1\|WP_013018822.1\|3813476_3816314_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_013947.1\|WP_144300813.1\|3796424_3798644_-\|CRISPR-associated-endonuclease-Cas3''	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NC_013947.1\|WP_041625013.1\|3800253_3803565_-\|error-prone-DNA-polymerase	unknown	unknown	gnl\|CDD\|235553
NC_013947.1\|WP_013018825.1\|3819287_3820220_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|274135
NC_013947.1\|WP_013018817.1\|3806446_3806824_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018818.1\|3806820_3808026_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NC_013947.1\|WP_144300546.1\|3809520_3810030_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013018811.1\|3793002_3793884_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_013947.1\|WP_013018813.1\|3795732_3796428_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl\|CDD\|187782
NC_013947.1\|WP_144300545.1\|3806052_3806385_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273840
NC_013947.1\|WP_013018810.1\|3791580_3791913_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013018822.1\|3813476_3816314_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	7.12074e-18
NC_013947.1\|WP_144300813.1\|3796424_3798644_-\|CRISPR-associated-endonuclease-Cas3''	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	3.35555e-47
NC_013947.1\|WP_041625013.1\|3800253_3803565_-\|error-prone-DNA-polymerase	gnl\|CDD\|235553	PRK05672, dnaE2, error-prone DNA polymerase; Validated.	0
NC_013947.1\|WP_013018825.1\|3819287_3820220_-\|AAA-family-ATPase	gnl\|CDD\|274135	TIGR02442, Uncharacterized_protein_Rv2850c/MT2916, cobaltochelatase subunit. Cobaltochelatase is responsible for the insertion of cobalt into the corrin ring of coenzyme B12 during its biosynthesis. Two versions have been well described. CbiK/CbiX is a monomeric, anaerobic version which acts early in the biosynthesis (pfam06180). CobNST is a trimeric, ATP-dependent, aerobic version which acts late in the biosynthesis (TIGR02257/TIGR01650/TIGR01651). A number of genomes (actinobacteria, cyanobacteria, betaproteobacteria and pseudomonads) which apparently biosynthesize B12, encode a cobN gene but are demonstrably lacking cobS and cobT. These genomes do, however contain a homolog (modelled here) of the magnesium chelatase subunits BchI/BchD family. Aside from the cyanobacteria (which have a separate magnesium chelatase trimer), these species do not make chlorins, so do not have any use for a magnesium chelatase. Furthermore, in nearly all cases the members of this family are proximal to either CobN itself or other genes involved in cobalt transport or B12 biosynthesis.	8.24766e-80
NC_013947.1\|WP_013018823.1\|3816310_3817570_-\|CHAT-domain-containing-protein	gnl\|CDD\|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	1.32168e-05
NC_013947.1\|WP_013018818.1\|3806820_3808026_-\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	3.21688e-09
NC_013947.1\|WP_013018824.1\|3817562_3819284_-\|hypothetical-protein	gnl\|CDD\|273935	TIGR02031, Magnesium-chelatase_67_kDa_subunit, magnesium chelatase ATPase subunit D. This model represents one of two ATPase subunits of the trimeric magnesium chelatase responsible for insertion of magnesium ion into protoporphyrin IX. This is an essential step in the biosynthesis of both chlorophyll and bacteriochlorophyll. This subunit is found in green plants, photosynthetic algae, cyanobacteria and other photosynthetic bacteria. Unlike subunit I (TIGR02030), this subunit is not found in archaea. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll].	1.54567e-15
NC_013947.1\|WP_144300545.1\|3806052_3806385_-\|hypothetical-protein	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	0.000108567
NC_013947.1\|WP_013018811.1\|3793002_3793884_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	3.38144e-123
NC_013947.1\|WP_013018813.1\|3795732_3796428_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187782	cd09651, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	1.78597e-76
NC_013947.1\|WP_013018812.1\|3793876_3795733_-\|hypothetical-protein	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	9.55879e-101

>NC_013947.1|WP_013018818.1|3806820_3808026_-|recombinase-family-protein
MTSAPIDLSTLPGYSWDTSTRAHITAFLGRCSTKDQQDPTTSIPGQATVCARRLGQGEDFAAYFWDVESGYMHLNARSQHDDDYYAELAVPLRRDGGLTDLLAAAHAGEITRVICERSDRAARDMLTILTVESHLEQWGVELVYATEPPPQRPGDMPASRLRMRRGQQMDAEIYRALMLENSERGQREHAAQGYSHGPAPYPYIAVIDPDAPARHDRYIRRPKRRLQPHPGPHRWDTSVHMARLRLEDARYRDIRIALNADPEKYPHDKPGGQWTDRRIRSLLLNPRLTGYAVFNRRSSKNGFTPIPMQEWTWSRQPSHKAVFTVDEWVQMVRMDAADRAPRDALERVRAAAHQHGYLLREVRSNDTHIVYAIGSREFTVPHGVLPEPAAEHIITWLETAA
>NC_013947.1|WP_013018817.1|3806446_3806824_-|hypothetical-protein
MNDATTHSVSVIVSRDHHRWAAEAPSISMWTFGRTLSQIHQHVTDAAALALDIHPEHVAVTLTVVSPELEELTRARAREQAALTAAVRRLRSQKVSWPETARILHVSQHEARAAVATASVEDNQR
>NC_013947.1|WP_144300545.1|3806052_3806385_-|hypothetical-protein
MWTVGRSDEVLLDKDSSGELGQADCGGIITGELVSVYDGTTVNRSSQLDIDDFVPLAETWDSGASQWSTHRRKTYATYLDDHRHLVAVTASSNRSKGDQDPAEWMPSMQQ
>NC_013947.1|WP_169313894.1|3803704_3804400_-|hypothetical-protein
MSAAQSPPSPHHAPGSPPGPGMRPPGVTPPVAPGRNIGLIVGLVIAGVAVLLAGVGVAVAVWPQEADSAALVAAGRDNVYGTTSTPCDLVDQQELADLVGFEGAKYDEETYGPDDDFDYNGMLCQLSTQVSDVTEYPLFELRAESHADTASADSAFEERVAEIGIEESVGLEQTMLLLKPNGSSPACLIMRNGNLVLTMELDSNYLDIPEDAAGDFLTDSAKKVMAALKDT
>NC_013947.1|WP_041625013.1|3800253_3803565_-|error-prone-DNA-polymerase
MTEGWGGRGRHLTWRQLRDRMVGRATSGSGVGKPRHLRLVTDDEPTPPASSPPAVEAGGYAELHAHSNFSFLDGASSPEDLVAEALRLGLSGLAITDHDGLYGAVRFAQAAKGTGLATVYGAELSIGLTGERAGVPDPSGTHLLVLARGAEGYAKLSAAIGNAHLAGGQKGLPDYGSLEGVAARLRGHVVVLTGCRKGPVRRALDAGGVDAARVELERLVELFGRDGVYVELTDHQAFTDGDRNEALADLASELGLSVVATNNVHYARSSRHRLSQVAAAVRANMPLDELDGWLPAAPTARLCSPDEMVERFAPFGGAVASSLRLARELAFDLDLVAPALPPFPVPAGHDEDSWLRHLVQAGAAERYGPLGSRSDVVRQLDHELDVIKRLGFAGYFLIVHDIVDYCRREGILVQGRGSAANSVVCFTLGITAADPIAFKLLFERFLSPAREGPPDIDLDIEARRREAVIQYVYDTYGRTYAAQVANVITYRRRSAIRDSAAALGYSPGQVDAWIAASPRRGGPALTELPADVGTYAGQLLGAPRHLGIHSGGMVICDRPIIDVVPVEHARMDKRTVLQWDKDDCADAGLVKIDLLGLGMLTALREARDVANAHYDVPVDLAALTPDDAEVYAMVHKGDAIGTFQIESRAQLQLAPRLRPANLHDLAVQIALVRPGPIQGGAVHPYLRRRDGLEPVVYPHRLAQPALEKSLGVPLFQEQMMQLAVDCGGFSPADADELRQAMGAKRSAERMHRLKDRFYAGAAANDIPHATIDDLWSRMEAFSGYGFPESHAISFAYIAYASCYLKRYYPAAFLTGLIRAQPMGFYSINTLIADARRHGVRIHPVHINHSHATTTLDGHGTPAPADAPARQWGSGGPAVRLGLNQVHGISDTVAERIAVGQPYTSITDLARRAGLTETHLENLATAGALTALGPTRRQALWMAAPAAANTHDTIDGTIQLTAPMLPGMSNAELTAADLTATGSSVDSHPIEHIRHQLDAHDATPIDQLATLPDRTRVVVGGIVTHRQAPETAGGILFINLEDETGQANIVCEPGLRLAYPREAHATPVLLIRGQLRNAGGVTSITADKLTPLHTPMPTKPRNFR
>NC_013947.1|WP_144300813.1|3796424_3798644_-|CRISPR-associated-endonuclease-Cas3''
MRGVAVLARRFAGEFGVGDLGYLTGLWHDAGKASCAWQDGLVRAEASGGPVGVDHKTLGCELAAEHGLQALGLVLHGHHGGLTSPGFVADALKNLSEAQRRNNAEARRGLTDLLAETGWARDVVLPWAKPLVAEMGLRLVFSALCDADSLDTAMHREGLAAPLVARDADVGLLWDRFQQRREDLLRHRPMSAVNVARQALFDECLRAAGKPRGMFRIPAATGLGKTINAGAFAMRHAAIHGMRRVVVAVPWLTITEQNAAVYRGLLDEGDEQVVLEHHSGVDFDVLPDCRRWERLASENWDAPFVVTTTVRLFESLFGRKREATRRLHRLSNAVVVLDEVQGLPYRLLLPILDGLRTLVDHFGASVVLCSATQPDFWNLGPFQGMEACDIVVPQELTRAVDGRVRYEWWTDPQPMLSDVADRACADESALVVVNTTKDASAVVDRWRELAGDSLVYHLSTRMCPAHRRYVLAAVRSGLAAGTPVLLVSTQLIEAGVDVDFAVVYRALAPADSLVQAGGRANREGRLPDGGRVVIFDPLDGGAPPTYRTLVGNTRRFFGPDKSAPDDTTAQLRYWRAVYDDTGVEGRGSIGRQIQSARQRLDYQSVTDGPQDLETGARDSKLAFRMISDDSVAVICPQWVGNGDGRGTGEKNLVSNEFNPRVLELIDQVRSGIGIGSAMRQLQPFTTNLHISAVRKPGVTALLAPLLGDVDTPGSLAVWQGDYDVTTGIALDPEMERFVL
>NC_013947.1|WP_013018813.1|3795732_3796428_-|type-I-C-CRISPR-associated-protein-Cas5
MTPHGTAITLPTDPHGHRPVAVQVWGDAALFTRPELKAERLTYPVMTPSAAKGVLEAIYWKPEMAYQVVAIEVLKPIKQFTVRRNETNDVASLRDAAKGVRRIDTAAKRDQRNAVCLRDVAYRIHAHIRLQPHANKPVVAYRDQFRRRVDKGACFAQPYLGTREFTAYFGKPDGTPARDELDGDLGIMIHTVGYDGDHAMEWFTARLDRGVLRVPERGIVAEASHISAAVG
>NC_013947.1|WP_013018812.1|3793876_3795733_-|hypothetical-protein
MLLQRLAQFAAQRETDENPIPAFYIEKPVRWVLRLHADGTPETLDMTDRADPSDTARRFGTPMAVPSVTKTSAPAPTPGVDTVEYVFGWVTTDPKANVKPDKVVKRHKAFIALNERWARDDPDSPASAIAAFYRDGHHRTIMEPMRINGRGEELQRVPAWSRGDLVCFEIDGAKAAASTSAQRFWASIAAERKGSGTSGLCLVCGEWAELLKTVPQQLPQRLVPGATQSASLVSVNKPTHGFDLTTELRHTPICQGCGLRVMSGLGMLLDDKQHSTGSGDSRMAWWTIGGEQVSLDMLLHPHQHLDDVHHLITAARTGHRHSVKDIDTGRFCSVIVGGNVSRIMVRDWVEQPLTQVQANLGRWFNDITTTDGDNTRLPGVGLLALACGRYDPKLTAESGGYLGFNKPGADRPDGVYRSLLQAALYGRRLPPGLSKHIIHRIRRDGYLDPARAALLHVGRIRQATTNDQKEPMEITTSSTEEPAKVAGQIFAMYEYLQWAATNPTPNKTTGRAERVNTSFTDRHFSGAITNPRRALTAGARISQAWLKRVRRDNPARAEWIDRQLTELYEHLNQAGGPPSTALLSQQSDFILGYYQQRQQRFANRSANNTTTETESNDE
>NC_013947.1|WP_013018811.1|3793002_3793884_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSEAHLDPTMRHDAVLLFDVTDGNPNGDPDAANQPRMDDETGQGIVTDVAIKRKIRDTVSLLKGDDPRFGIFVEAGHALNTRIAQALKESADDSDNARQWICDHYFDVRMFGAVLSTGDKIPGSKKRGAGQVYGPTQLTFARSIDAISPVEHTITRVTQTKQADIDAGESTELGAKWTVPYGLYRTHLHYSAPKATKTGVTADDLHTLWKAIQFMFEHNHSAARGEMKLCGLYVFSHSSAVGDAPAHQLFNTIAISPLEADKPPRHHTDYRRQFEKASVPSRITSTVLTDLWP
>NC_013947.1|WP_013018810.1|3791580_3791913_+|hypothetical-protein
MTVHALHRAADLIEQRGWTRGGYCYPDAEGYCMDKALLAVCGLCTACENKHDLTDEYRDALAALRAALNVATCWDLWWWNDNSRRTKSDVVRLLRRAADHAPARRKSLTQ
>NC_013947.1|WP_144300546.1|3809520_3810030_-|hypothetical-protein
MNETTTAAATMSIRCLVMSGKHEKGKRHLRSAMNVTPMCRMPLGIVRRCQQMLTPLPRTHVRVMHQAISPHGGNREEPDWPHPVTQPTSTVPQLKRKWETRPKGKKNCNRLPKFVAQSSDVITGQQAYHSVVQYRPFESGRDDLDFAGDLIENGGDEFAKKLSKNDLPR
>NC_013947.1|WP_144300547.1|3810153_3811110_+|helix-turn-helix-domain-containing-protein
MATKDPVIDRVGLVEEFAAQLDKLRRQAGGLTFRQMAAQIQGTVAASTLCRAVNGKKLPAWRVVQLFVEACGGDVEHWRTQHIRVSNALRSGAAQDVDSSTAPPSRVSDQRKMPTVQEALFRGAIRNMDRALIELDAVVDDPLTASIRIPGGHLGDQVHLLRQLWAVLNHRRRPVDSPASFAQCMKELKEHAGLSLLQISRQTDPSHMSKKARQDLGLDVSKPIAVSTLSDLCNPHQGRLPNAATLDRFLHALGYSAKEREGWQRLRADLAVQYDRRFHRPARAKSSRVKRPSFRPGGDMEIFGSYIDNEGFSLWDPY
>NC_013947.1|WP_013018820.1|3811343_3811619_-|hypothetical-protein
MANPVTDPDVSNTSGPARFATVLVNDPGRFKKLSFSRQLVRVNGFVGIVKRLQVSIVFIMVRVNGIMVTLMAFTVTIGGAARVSPSFEGTS
>NC_013947.1|WP_013018821.1|3813246_3813387_-|hypothetical-protein
MTGVRVMPVKLRWGDIALLGLIAAAIVRIGLTITLVSTRGRVGDPD
>NC_013947.1|WP_013018822.1|3813476_3816314_-|sigma-70-family-RNA-polymerase-sigma-factor
MTSTTAMIRIEPLVRWPRHMTSGQAHLVEVDLRLLDEHWPYENEEFTFHVLLAGMPFHEVRTVGPPEIVVHRFGGSYGSCRFVVTPTVASGDHPLALSLETDGGAHVTTIELPVHVAAETRDEVREAVVPAAGRSGRAEHRANPAVTARSVVPLLAAHIGPDFSTDAVAAVAGVDLPTAGRLLAELAADGSVDESRDARYSLSPKGRGRIETTPADLRDAARRRLLDHYRQTGQLALEIMAPRGVSVVQGVIGFRDRSAARDWLDEETSNMAAYASLAAENGWMEHARELLQVLSQHLLDTGHHETFFRLCRRMANASDHEVKDLALNELADTYLELGRYLEAMECLNRVRELEASSAGIAGHAEALNKLGVVHSRLGQHERAYEFHQRALEFARGTENRLLIVDTCVQLGISLVSQGRLQEALARFAHARDLSEELNDQYRVALSTEHLAQVHAALGNVDNGRELWAEAAQRYRSLARPPTDTSRSDTEPVPGVAGRVSDERRLTEAIEQLASGRRAEQDVGIQTLETLARQVKQLRQTAVDELCRYVREFSERETNTAKSSHHGRVRHVLDILVDLSHATDANVEPTNIDLSGAVLPQVDFTDCRFGYASFNRAVFTRQANFTNVVFDGPAQFSDTMFEFPDAGSAVFTSAKFQGAADFSRAEFNGRASFLSVSFLDEVIFRDANFMAAALFTGGSGHGAVRFDDVIIAEPESLRLEDFEVLQPSAAHRWPVGWSPYTTANEGLSLRRAPEAGVSRADERLALALAHMGEPDALDEVIAEYSPLVWRVARGQGLDRSMAEDVVQATWMRLVQSLPRDVQNLKNLQGWLTSSAKREAWKRARQARLEIPSSLEWFEDLRSSENVEDDVADRMNTAPRYQAIWAALNQMSDVCRALIQVIAYTDRPDYDAVARQLGIARGSIGPTRGRCLAHLRRLLQENSDFND
>NC_013947.1|WP_013018823.1|3816310_3817570_-|CHAT-domain-containing-protein
MAERRFPVMSRLLSARRARREPPPDQAHSAEARVPDTGAQAFEPMGAINVDPTASSPAGTVKLRVVRPFGKDEHVEITAKSPGVPKLACIDGAAVREPSTDLSDVIKVGGLAPSEVLARIRNWSLANGAAVTGWLSRARRHCGEEPRLLIHDETDANIPWELLWLPDDPDRRQGAYVGCSFVTARWTPLQVTRREQRNHPYSTLRCRGEVLAYVGEDMAEADLSMIDGYGARTVASARLLFKELADPGRPLSLVYIGAHGRFSTRSFEFTVAEVALGRIFAETFPRIDDAAPLVFLNACHSGRVIIDESDTSLPSSFAEVFLRSGAAGFIGTTGAVREREARQVAKGILNALARQPGKPVATALRDFRRQVVAEHSRQTWSADRGDEESRALPLLYTFMYVYYGSLWTTVELSGRGVGE
>NC_013947.1|WP_013018824.1|3817562_3819284_-|hypothetical-protein
MERMATALACAAIDRHLAGVLLFNLDPGRIGALGRWLAALLGSQTRTVLAGAATHDEDLWTRFSLSGSQVSITPGALFDQTVVLVPDLTQLSDAGARAAIATIGADVAHIERDGHQSIQVPKARWLVGCRREGAGELSRHLLDRFALRVDAADVPGELDPPPRSWRDAVERAAHATPLPMSTRVLGYVMELFTAADAGARRPVAVARLARAIARLDGDETVSVRHVDLATEHLGIPRHHRLSVVDDASPLSRNDAAGPAPNRTEEAIQAPEGPVPQYLAAGAGFEAPSAVHTSLVAVPYPEDEPMTRSRLGSVNLDHTSPQWSNVAAHGRPWGTVPAHDLTDLSITASLLEACKLQVMRCPGHHGSAHRLHVTAADLRRHKRTIQPTDLLVLLVDHTCGGANWNLPAALGAHIAWAYEQRAHIRVVELGDADSADELSARQFVVRNALDRRLHRVLSRRPGRATPLAHGIELAGRVLRRFAGSDRSVARDTRFVLVTDGRGNVPLSASLTGQVDFPVARRGVEDSLYAARQIRTLPRTQTIVVCPGSHRTSPVVTELAQVLGADILTGDGDNG
>NC_013947.1|WP_013018825.1|3819287_3820220_-|AAA-family-ATPase
MTDDIQVLPYSYVVGQDALKHALEISYVSRGSGGVLIAGERGTAKSTTVRAFTRMVNDRLPVTLPINATDDRVLGGWRIEELMRGEARPQPGLLETANDGVLYIDEVNLLDDHLVNVILDVASTGILVVQREGRDEQIPVSFTLVGTMNPEEGGLRPQLLDRFGMAVPVSTETDVGRRAEILSTVLRFDVEGALPSSTWLSQGTRNDQARREALNAARDRVSDSVVSDKIVDLCAQVATEFKATGHRSEIVMVNAARAETALDGRTAVEPRDVAAVAPFALLHRRPEAAFAEDLSWTAADQKLLDALTTE
>NC_013947.1|WP_144300548.1|3820209_3820572_-|hypothetical-protein
MVVVFSEAQPGRPMIRIEVGEVDELDDPGRYYEDDATRVALPEKVRERGRTLFIEALDMLDSCCEAVSEKFAKKAGNGPSEIEMRMALQLDGKAGAKFVELGASAHMDVVMRWKDPSDDR
>NC_013947.1|WP_041625016.1|3820615_3820819_-|hypothetical-protein
MDARTGLAKATDDVVDTDKCPVDNVELERLQFEARRGDPDKEFAGGYIAAYGDQVCELKAVAFAALH

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Crispr_ID: NC_013947_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_11

4610241-4610334

Orphan

Consensus_repeat	Method
CGTGGCGCAAGTCCAGCCGCAGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_11

>merge|NC_013947|11|4610241-4610334|CRISPRCasFinder
CGTGGCGCAAGTCCAGCCGCAGCGGGCAAAGCAACGGCACCGCTTGCGTTGAGGCGCGTGCCGTCGCGACGTGGCGCAAGTCCAGCCGCAGCGG

>NC_013947|11|10|4610241-4610334|CRISPRCasFinder
CGTGGCGCAAGTCCAGCCGCAGCGG	GCAAAGCAACGGCACCGCTTGCGTTGAGGCGCGTGCCGTCGCGA
CGTGGCGCAAGTCCAGCCGCAGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013019537.1\|4610670_4611195_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300587.1\|4604856_4605192_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300588.1\|4614384_4614627_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013019543.1\|4616304_4616862_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013947.1\|WP_013019532.1\|4608277_4608676_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_013947.1\|WP_013019538.1\|4611226_4611664_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013019545.1\|4618394_4618859_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_013947.1\|WP_083787190.1\|4609382_4610225_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NC_013947.1\|WP_013019527.1\|4602314_4602953_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013019533.1\|4608691_4608979_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013019526.1\|4601106_4602249_+\|S8-family-peptidase	unknown	unknown	gnl\|CDD\|173790
NC_013947.1\|WP_013019540.1\|4612732_4613575_-\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NC_013947.1\|WP_013019541.1\|4613660_4614392_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373062
NC_013947.1\|WP_013019525.1\|4600008_4600950_-\|glutathione-S-transferase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|223512
NC_013947.1\|WP_013019530.1\|4605249_4606851_-\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|237436
NC_013947.1\|WP_013019539.1\|4611656_4612688_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013019528.1\|4602958_4604821_-\|hemolysin-type-calcium-binding-protein	unknown	unknown	gnl\|CDD\|373366
NC_013947.1\|WP_144300828.1\|4617027_4618236_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|236823
NC_013947.1\|WP_013019531.1\|4607082_4608285_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NC_013947.1\|WP_144300827.1\|4614714_4616157_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013019531.1\|4607082_4608285_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	4.56663e-76
NC_013947.1\|WP_013019545.1\|4618394_4618859_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.75863e-35
NC_013947.1\|WP_013019532.1\|4608277_4608676_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.84739e-21
NC_013947.1\|WP_083787190.1\|4609382_4610225_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	0.000158425
NC_013947.1\|WP_013019541.1\|4613660_4614392_+\|hypothetical-protein	gnl\|CDD\|373062	pfam14428, SCP1201-deam, SCP1.201-like deaminase. A member of the nucleic acid/nucleotide deaminase superfamily prototyped by Streptomyces SCP1.201. Members of this family are predicted to function as toxins in bacterial polymorphic toxin systems.	3.01548e-10
NC_013947.1\|WP_013019526.1\|4601106_4602249_+\|S8-family-peptidase	gnl\|CDD\|173790	cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, Peptidase S8 family domain in ProteinaseK-like proteins. The peptidase S8 or Subtilase clan of proteases have a Asp/His/Ser catalytic triad that is not homologous to trypsin. This CD contains several members of this clan including: PCSK9 (Proprotein convertase subtilisin/kexin type 9), Proteinase_K, Proteinase_T, and other subtilisin-like serine proteases. PCSK9 posttranslationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR. Characterized Proteinases K are secreted endopeptidases with a high degree of sequence conservation. Proteinases K are not substrate-specific and function in a wide variety of species in different pathways. It can hydrolyze keratin and other proteins with subtilisin-like specificity. The number of calcium-binding motifs found in these differ. Proteinase T is a novel proteinase from the fungus Tritirachium album Limber. The amino acid sequence of proteinase T as deduced from the nucleotide sequence is about 56% identical to that of proteinase K.	4.38548e-119
NC_013947.1\|WP_144300827.1\|4614714_4616157_-\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	7.6744e-83
NC_013947.1\|WP_013019525.1\|4600008_4600950_-\|glutathione-S-transferase-C-terminal-domain-containing-protein	gnl\|CDD\|223512	COG0435, ECM4, Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	4.71541e-143
NC_013947.1\|WP_013019530.1\|4605249_4606851_-\|phosphoglycerate-dehydrogenase	gnl\|CDD\|237436	PRK13581, PRK13581, D-3-phosphoglycerate dehydrogenase; Provisional.	0
NC_013947.1\|WP_144300828.1\|4617027_4618236_-\|amino-acid-permease	gnl\|CDD\|236823	PRK11021, PRK11021, putative transporter; Provisional.	7.52843e-51
NC_013947.1\|WP_013019543.1\|4616304_4616862_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.4845e-07
NC_013947.1\|WP_013019528.1\|4602958_4604821_-\|hemolysin-type-calcium-binding-protein	gnl\|CDD\|373366	pfam14891, Peptidase_M91, Effector protein. This family of proteins contains an HEXXH motif, typical of zinc metallopeptidases. The family includes the E. coli effector protein NleD, which cleaves and inactivates c-Jun N-terminal kinase (JNK).	3.98597e-62
NC_013947.1\|WP_013019540.1\|4612732_4613575_-\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	1.29949e-80

>NC_013947.1|WP_083787190.1|4609382_4610225_+|helix-turn-helix-domain-containing-protein
MTGNGRLPSTPAVELGLQLKAERERPRPGRPKGFRKADIPRDILSSRTLFDIEKGRKSKVTRGMVRDLCAFYETDRALVERLVTLARATYMDDWTDSYAGAVDKDDWLYQNREDRAAKLMFHDSVFIPSLIQPASYVDMMERTTKATVDKLDYEQAKQFRMNRQERWIASRRPMTCLIGEAAFSLKLGDGVDEDVRSHVLKLARLPFAEIRVIPFAAGRYDLLGWEVNLLEFGSGEEPVIRARTARGGGFVSATSRRGRFFREAFPLATEVSVPVKEYLT
>NC_013947.1|WP_013019533.1|4608691_4608979_-|hypothetical-protein
MTIYGQFRDPLHTYVVTSSSMPDTIRVFAGDPHSAEMVCTISNLSARPYPSWNAKWYSNWPEWKRRFTDHAVSIWRTHNDHRPSPTRREFRTCDG
>NC_013947.1|WP_013019532.1|4608277_4608676_-|response-regulator-transcription-factor
MSTIVYPPTRGLSAWEAACRSAAIIAREAARDRRRELLTHHGRVLLNALAAAGIDLEPKPPVVVRPPGCRLTERELTVVIGMSNGKSNARIGRELHISEDTVKTYARRLFRKLGVGDRTQAVAVALRTGLIR
>NC_013947.1|WP_013019531.1|4607082_4608285_+|cytochrome-P450
MTGRSTPLTALPMTRAEGRPFDPPPLLARLRDEAPLRRLTYADGHQGWLATGHEEVRTLLGDNRISPRPDLIHLPFELEGITTLPAPAPGAVNQLDGPDHARLRQPLVGWFTVRRMRQLTHQVETLVADLLDDMADRGPDVDLVDEFAYPLPVTVVCDLLGVPESDRATFRDLVTTSGRSDLPIPDRLAANEQLGGYVGELVAAKRARPADDIISALTETDLDDTDVVGLSAFLISAGFDTTANMLALGTMALLEHPSQLAAWRADPGITNTAVEELMRYLSIVHTTVHSAVDDIEIAGQTIKAGDSVTLSFMAANRDPRKFPDPDRLDLRRNATGHLGFTHGAHACLGQQLARVEMRAAFPALLRRFPNLRLNIAIEDVPLRDPLILVYGLDRLPVTLT
>NC_013947.1|WP_013019530.1|4605249_4606851_-|phosphoglycerate-dehydrogenase
MTTPVRPVVVIADKLADSAVAALGGDFDVRVIDGTDIPTLHSALADADAVIVRSASRIDAAALAAAPKLQVVARAGVGLDNVDINVATERGVMVVNAPTSNIVSAAEQAVALLLATARNTTIADASLKRGEWKRSQFTGVELAGKTVGVVGLGKIGQLFAARMAAFDTNLIAYDPYVQPARAAQMGIQLVSLDDLLLRSDFISIHLPKTPETIGLIGKDELDKVKPGVRIVNAARGGLIDEAALAAALADGRVAGAGIDVFATEPCTDSPLFALDNVVVTPHLGASTREAQDNAGLQVVKSVKLALAGEFVPDAVNVKAGSGVAEDVRPLLPLAERLGRLFTAIAEGPAQSVTVEVRGEVIDSDVSVLQLAATKGLFVDVADQVTYVNAPLLAADKGIDVGLFTSAESPEFHNQVTVRGALADGRAVSVSGTVTQGPREVRKLTEIDGYDVEIDAEGPLLIMRYTDRPGIVGLIGGSLGDESINIGAMQVSRREAGGEALMIVATDAEVPADLLTKLAGTVGATSASAVTLTD
>NC_013947.1|WP_144300587.1|4604856_4605192_-|hypothetical-protein
MAKEVRANPTDLARLAEAFLTESKDLFGALKTARGEISLGGDVFGNADAAAKVQAAYTGAIEAAGTDVERLIAVCEEDMESLYQVAFAYQYTDQNNGQTIDNVDDNNPLTP
>NC_013947.1|WP_013019528.1|4602958_4604821_-|hemolysin-type-calcium-binding-protein
MPEPHINVDTRYWNLEGNPGKLEKAATAWRELAKVGKTSADNVETASNDLVNGKWAGDCRDSFAEHRKTLIGSLDGADTRAGEIAGHLDGIAALQRKFQGFLTEALGKITGAVPNMCGANPPPGGSILTFMPENPEQSKAVLDSVEKAKKIRKSYDDELGPYAGKFDESKTKWEKDSKAWEAIVENQADPFTVPPEADKTSVIMVDGKAVVNTGSGNDKVNVTTDKDGNVKVEVNGVVQTFPPGTPVVVRGGEGNDVITVDKNTKVNLTLLGGDGNDRVHSAGGADTIVSGHGKDDVYAGEGNDYVSSGSGIDYVDGQDGNDDIGGGTGNDTLYGLGGDDYINGGEDADYLEGAKGNDTIDGGTGPDIISGGKGDDTLRGGGTGTDYDGYDPSKPERGDVFYGGEGKDDVTAGSGKSDAYIQDGDSTHNVDKTVTVEISDAGGFIKFEGSDEFKERMQADLDMMRSSPTAQQMLEGLESKRDPNFWGGEHSLTIVEQSAAQDGGSAESGDESIWGNKDSKINMNPGYTPNYYDGRSSTVLYHEMAHVYDFWNNGFDDTPYHGDPNGQNKGTEQGERTAVGLEVDHDHDSNTPDKRDDTHPWELTENALRDEYNLPKREEY
>NC_013947.1|WP_013019527.1|4602314_4602953_-|hypothetical-protein
MKRSLPALAIASALLLTACGQRGGVDDGEGGAAMDGAEFSSSIDVDGDDVTVEFTLNNTGSGALLAYDRGWVTDPKSPTDEELEPTEDDVQIIVDGDSVEFGLRIIHACHGNPQGEMPPEEVPECETDTATGGRYAATIVEPDRALSREYQFDAASVWPDYPTKLAGTTIDLKGKDVRFCLGVDRPENPADEELYPPEAAETVLCGEAVTVD
>NC_013947.1|WP_013019526.1|4601106_4602249_+|S8-family-peptidase
MRRILAVTLAVTALTAAWAVPAQAEPAPLVKITKAQGEKVPGQYIVSFKSDSGVNSAVKSLNKKPLFTYDDALDGFAAKLSAGELSALQHNPNVAMIEEDGVVKVDTTQSNATWGIDRIDQRNLPLSTTYTYNSTGSGVTAYIIDTGIAATHSQFGGRASNVYNSAGGSNSDCNGHGTHVAGTVGSATYGVAKGVALRGVKVLNCQGSGSWSGVISGMDWVTANHAANSVANMSLGGAYNASVNAAATRMANAGVFTAVAAGNENTNACNRSPASASNVTTVAASDRTDTKASFSNYGNCVEVYGPGVSITSTWLTGTNTISGTSMASPHVAGVGALYKAVNGNVSSATVNSWIASNATSGVIKSNPSGTPNRLVYKANL
>NC_013947.1|WP_013019525.1|4600008_4600950_-|glutathione-S-transferase-C-terminal-domain-containing-protein
MVENNHAVDESGEFQRSRSHFADRITADGSSGWPVEPGRYRLIVSRACPWAHRMLIVRKLLGLEDVISLGVADPIQDELSWRFTLDPGDIDPVLKIAYLGDAYRAREPEYDGGVSVPAIVDIPSGKLVTNDYLQMTLDLSTQWTAYHREGAPDLYPEGMRDEIDAVIEPIFKEFNNGVYRAGFATSQEKYEAAYRDVFGRLDALEERLSTRRFLMGDAITEADIRLFTTLVRFDAVYHGHFKCNRNKLTEMPVLWAYARDLYQTPGFGETVDFDHIKRHYYVVHSDINPTGIVPVGPDASGWSTPHGRESLTN
>NC_013947.1|WP_013019537.1|4610670_4611195_+|hypothetical-protein
MGQMADRLAALVVTAFSPDGQIEGSYGAAAGANIRFNGNSYRHYTERGLGHQLSRMAVLVWIAHQRGHDATVAEVTGQPVSRRQETWDARRRRFREEQAETESEGMSTGGLVYFRNTGMRDWHIVIRDGTLSKLDEPEFVKEFLSGYAALSLDYRHKMTKLRTKHYGPDIWMKK
>NC_013947.1|WP_013019538.1|4611226_4611664_+|hypothetical-protein
MCSDVVAGDLNDLRIAALNLGKMSELYTNGAFVLGIAQGADTETYGRPHEWWSYVEQQLATALRFTYDRLNDGQEALLAAIDAYAYVDGDNAKGLTDVGKEYKEYISNPNNVGDEKYYDPPPLHTMVDAPDLGDKPEGWEEKYDG
>NC_013947.1|WP_013019539.1|4611656_4612688_+|hypothetical-protein
MAKPPPGKSSGRGSINDDEGKIEVESGDIPHVTDTEIKDAAEKVRETAVSKGKSERDKAEGDYTIMNPDSMIRPDFASDEEIEEQAKWIPGRFEPYITPNPLDIETLVKRADTIATVFNCSGNNLTDSRLSGAYEIAMTRSDEWEGKAGENFEKYMASLPTIMGNHGKVANMLQIEAQKMIELYKNRRKGAKDIADQAVKAIEAIDDSKGEGLEFLLAVIITIGTFVGLGGGGLAIVGAGVASGATLGGPFLPDDKEELPLGADTIEEVLENMKKALDELDKSITEQEDTLIDAMKFNESEIRPHISDDFGKETLLLPMRPELAGADVKTIKERFHQFTDGDR
>NC_013947.1|WP_013019540.1|4612732_4613575_-|PhzF-family-phenazine-biosynthesis-protein
MAGSRDFAQVDVFGQAPYLGNPVAVVLDGDGVEDEVMRRIANWTNLSETTFVLSPNDPEADYRLRIFTPGLELEFAGHPTLGSAHAWLENGGKPKRAGRIVQECAAGLVELRQGEGGLSFAAPPRRRVGELEAEHLAAIVDAFGIEREAVVSHQWVDNGPGWAVIRLGSAEEVLALEPDFSRFPTAMVGAVGEYPKGSEFAYELRTFAPASGVFEDPVCGSMNASVAQWLTGAGEMPAAYKVSQGARLGRRGEVAIAVEEDGTVWVGGATTTCFRGTAIA
>NC_013947.1|WP_013019541.1|4613660_4614392_+|hypothetical-protein
MSMLRRLVAALRAARTRTVETRDKIIAAKSRSDAGLLAFQQATNGSIDSRPAEAIANLQRAKTHLDEAQRLVANSDAAVDNYINAILGGASAATAQPSAVIPASKPSRFKPMRTDPAKADEIRPHVGKDRAVATLWDADGNRVLGLHSADDDGPAATAAWKPPWRDYVRLRRHVEAHAAARMHQDGHKTMVMYINLPPCKYFDGCKLNLEDILPKGSTLWMHRVFQNGGTKIYQFNGTGRAYV
>NC_013947.1|WP_144300588.1|4614384_4614627_+|hypothetical-protein
MSEFVESIPVTLDPDIHDDLMSSWESGLGSRALIEYARSLGIEPPDDRDGWLIVHEFGPDGVDLGLRWDNSDDEPVNQVD
>NC_013947.1|WP_144300827.1|4614714_4616157_-|MFS-transporter
MDLTILNVALPEIDAALRPSSVQLLWIVDVYGLAVAGFLVTASGLADRFGRRRMLLVGYAAFGTVPLIVLFADSAPWLIAARALLGLGGAFIMPSTMSMIRDLFADPKERAVALGLWGSMAAVGAGLGPIIGGILVQNFSWHAAFLINTPIMVLAIVFALWLLPESRGGAVPWDFLGIALSIIGMISLMYAIKTIGKHGITDPTALLTGTIALVSLIWFARRCLNRREPLLDLRLLRRRPLSAGLMCALISSVAMAAMMLLLAQWMQLVMEYTPIQTGIHLLPVAIVSGVISPLAPRIAQSIGTRTVMAGGLAVGGLGFAILYLGGDHLDYPLVALSQSLVGVSMATLAIGSAVIVASVPVERTGNAAAMEETSFELGNALGVAVLGSIAAVVFHNLMAATRLESLGLTGSAASTASDSIGGALSVASHTGNTALADHARAAFTESLGIVGLAGGVLMLLAAVAVWYLTPRGLTVEGGHH
>NC_013947.1|WP_013019543.1|4616304_4616862_-|TetR/AcrR-family-transcriptional-regulator
MGRREIAVAALRLLNAKPTASMADIAAAAGVSRATLHRHFAGREELVRLLGELSIESWREALDNADIDTATASGDAAQLRSALEVLCGQLVRDAYEHGFALTEPSFETDDEMVAASEVQQNRELAFYAAAQKAGVVRDDMSATWIAHAVFGLLVGLREALRRGDIAVRDAERLLRETVFGGIAVH
>NC_013947.1|WP_144300828.1|4617027_4618236_-|amino-acid-permease
MYIGAILGPGILALPGLAAAEAGPASIVTWIVLLGLSVPVALSFAALAAKFPDAGGVATFVRRAFGARPAGIVGWWFYCVIPIGAWTAGIIGAEYVGEALGLGGTGKLLIGLGLLAAAFGANHLGLRLSGGTQLLLMIVLVLLLGVATVAGALHVSAANLTPFAPHGVAGIVSAAGVLFYAFAGWEAASHLSGEFTDPARQLRRVTGYTLLIVSVLYIGLSIVTVGALGGDAATSPVALTALLTYALGPAAAPVTAIIALVLSFGALNTFVAGASRLGAALARDGDLPAVLARGGRPGEIPHRSLLLLGSLTAVATTVSITFSFNLDDLMRATSACLAAVTVLGCAAAVRLLRGRSARAMAIAATGFTTVVLASMAWYLLVPLGIAALALGYRWTRRERPTH
>NC_013947.1|WP_013019545.1|4618394_4618859_+|Lrp/AsnC-family-transcriptional-regulator
MDELDARIVRLLQANARQSNRELARTLGIAPSTCLERVRTLTRRGVIRGYHAEVDLPAMNRDVQALVSVQMRRHSRPIYEAFRDAAKNWREVITLFVVSGEHDIVMHVAVPDSDSLHSFLVDRLATRQEVARFQSSLIFQRIHNNVLDVLDSGD

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Crispr_ID: NC_013947_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_12

5090912-5091005

Orphan

Consensus_repeat	Method
TTGTGGCTTGGCTGGCGCGGCCCG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NC_013947_12

>merge|NC_013947|12|5090912-5091005|CRISPRCasFinder
TTGTGGCTTGGCTGGCGCGGCCCGGCCGGAGCTGGCGCGACTCGCGGGCGGCCTGGCCGAAGGCGGCGCGTTGCGGCTTGGCTGGCGCGGCCCG

>NC_013947|12|11|5090912-5091005|CRISPRCasFinder
TTGTGGCTTGGCTGGCGCGGCCCG	GCCGGAGCTGGCGCGACTCGCGGGCGGCCTGGCCGAAGGCGGCGCG
TTGCGGCTTGGCTGGCGCGGCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013020004.1\|5086849_5087314_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239316
NC_013947.1\|WP_144300845.1\|5098499_5100674_-\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|368494
NC_013947.1\|WP_013020001.1\|5083494_5085141_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020009.1\|5092732_5093584_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|380091
NC_013947.1\|WP_013019997.1\|5079752_5080622_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_013947.1\|WP_013020000.1\|5082851_5083310_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020011.1\|5095196_5095850_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_052305122.1\|5091088_5091898_-\|fused-MFS/spermidine-synthase	unknown	unknown	gnl\|CDD\|179854
NC_013947.1\|WP_013020012.1\|5095930_5096401_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013019998.1\|5080683_5081811_-\|epoxide-hydrolase	unknown	unknown	gnl\|CDD\|377658
NC_013947.1\|WP_013020014.1\|5097996_5098302_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300615.1\|5101084_5101462_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300614.1\|5085186_5086146_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183743
NC_013947.1\|WP_013020003.1\|5086169_5086676_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020005.1\|5087360_5087783_-\|DUF3052-domain-containing-protein	unknown	unknown	gnl\|CDD\|378615
NC_013947.1\|WP_013020013.1\|5096397_5097978_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|283837
NC_013947.1\|WP_013019999.1\|5081865_5082876_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_013947.1\|WP_086013330.1\|5088018_5090760_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl\|CDD\|236500
NC_013947.1\|WP_013020010.1\|5093741_5094752_+\|threonine/serine-dehydratase	unknown	unknown	gnl\|CDD\|181319
NC_013947.1\|WP_013020008.1\|5092066_5092729_+\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|365866

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013020004.1\|5086849_5087314_-\|peroxiredoxin	gnl\|CDD\|239316	cd03018, PRX_AhpE_like, Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater similarity to 2-cys PRXs than 1-cys PRXs. PRXs are thiol-specific antioxidant (TSA) proteins that confer a protective role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. The first step of catalysis is the nucleophilic attack by the peroxidatic cysteine on the peroxide leading to the formation of a cysteine sulfenic acid intermediate. The absence of a resolving cysteine suggests that functional AhpE is regenerated by an external reductant. The solution behavior and crystal structure of AhpE show that it forms dimers and octamers.	1.66476e-76
NC_013947.1\|WP_144300845.1\|5098499_5100674_-\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|368494	pfam05547, Peptidase_M6, Immune inhibitor A peptidase M6. The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.	3.15288e-159
NC_013947.1\|WP_013020009.1\|5092732_5093584_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|380091	pfam18014, Acetyltransf_18, Acetyltransferase (GNAT) domain. This entry represents a likely acetyltransferase enzyme that is related to pfam06852.	9.26481e-17
NC_013947.1\|WP_013019997.1\|5079752_5080622_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.53817e-10
NC_013947.1\|WP_052305122.1\|5091088_5091898_-\|fused-MFS/spermidine-synthase	gnl\|CDD\|179854	PRK04457, PRK04457, polyamine aminopropyltransferase.	1.52527e-10
NC_013947.1\|WP_013019998.1\|5080683_5081811_-\|epoxide-hydrolase	gnl\|CDD\|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	7.77047e-57
NC_013947.1\|WP_144300614.1\|5085186_5086146_+\|hypothetical-protein	gnl\|CDD\|183743	PRK12785, fliL, flagellar basal body-associated protein FliL; Reviewed.	0.00163162
NC_013947.1\|WP_013020005.1\|5087360_5087783_-\|DUF3052-domain-containing-protein	gnl\|CDD\|378615	pfam11253, DUF3052, Protein of unknown function (DUF3052). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.36642e-56
NC_013947.1\|WP_013020013.1\|5096397_5097978_-\|hypothetical-protein	gnl\|CDD\|283837	pfam06259, Abhydrolase_8, Alpha/beta hydrolase. Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile.	5.7268e-19
NC_013947.1\|WP_013019999.1\|5081865_5082876_+\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.14082e-38
NC_013947.1\|WP_086013330.1\|5088018_5090760_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl\|CDD\|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NC_013947.1\|WP_013020010.1\|5093741_5094752_+\|threonine/serine-dehydratase	gnl\|CDD\|181319	PRK08246, PRK08246, serine/threonine dehydratase.	1.27223e-140
NC_013947.1\|WP_013020008.1\|5092066_5092729_+\|trypsin-like-serine-protease	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	0.00262675

>NC_013947.1|WP_086013330.1|5088018_5090760_+|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MTNERKRPVISDGLPSQLPDIDPQETAEWLESLDGLVDEQGRQRARYVMLRMLERARESQVGVPALTSTDYINSIPPEAEPWFPGDEHVERRIRAYIRWNAAMMVHRAQRPGIGVGGHISTYASAASLYEVGFNHFFKGKQHAGGGDQIYIQGHGSPGIYARAYLEGRLTEHQMDGFRQELSHPGGGLPSYPHPRLMPDFWEFPTVSMGLGPQGAIYQAQFNRYLQHRGIKDTSQQRVWAFLGDGEMDEPESLGAIHLAAREELDNLTFVVNCNLQRLDGPVRGNGKIIQELESFFRGAGWNVIKVIWGREWDSLLAADTDGALVNIMNSTPDGDYQTFKAEDGGFVREHFFGRDPRTKRMVEPLTDEQVWNLKRGGHDYRKLFAAYKAATEHTGQPTVILAKTIKGWTLGSHFEGRNATHQMKKLTLDDLKSFRDRLYLDIPDSALEENPYLPPYFHPGKGSDEIEYMMERRKSLGGPVPTRRTKHKALELPPSSTYDVVKKGSGKQKVATTMAFVRLLKDLMKDKNIGPRWVPIIPDEARTFGMDAMFPTSKIYSPHGQNYLSVDRDLFLSYKEAEKGQILHLGINESGSSSAFIAAGTSYATHDEPMIPMYIFYSMFGFQRTGDHLWAAADQMTRGFLLGATAGRTTLNGEGLQHEDGHSPLLAATNPAVLTYDPAFGYEVAHIVEDGLRRMYGEKQENIFYYLTVYNEPITQPAQPDGLDVNGVLKGIYKYRSAADNANLPKVRLLASGVSMQWALKAAELLAADWGVSADVYSVTSWTELRRDAVACEEANLLNPDAEEQVPFITQQLSDGSGPVVAVSDFMRAVPDLISRWVPGEYTSLGTDGFGQSDTRGALRRHFHVDGESIAVAALRQLARRGDLPTEAAAQAARKYAIEDVSAAEAGETGGDS
>NC_013947.1|WP_013020005.1|5087360_5087783_-|DUF3052-domain-containing-protein
MSATAGSADGVRTIIDKLGIDTDAVVMEIGFDSDIDSALREAVIARVGELHDEDTDEVVDVVLLWWRDEDGDLVDVLMDARSPLSEEGVVWLLTPKPGRDGHIESAEISEAAPTAGLSSTSSVNAGEDWVATRLVAPRGR
>NC_013947.1|WP_013020004.1|5086849_5087314_-|peroxiredoxin
MTVAVGTQAPDFTLKDQNNQEVTLSSFKGHKNVLLVFYPLAFTGVCEGELCGVRDNLSSYQSDEVQVLTVSVDSVFTHKVWADKEGFEFPLLSDFWPHGGVAKTFGVFDEDKGIANRGTFVIDTTGTVRFAEMNLPGEPRDQGAWQKALAELTG
>NC_013947.1|WP_013020003.1|5086169_5086676_+|hypothetical-protein
MGRLADTLDALSVRALSPDHRIQGQLHHRTKVDISFTSEDSYYEYKSEQAVAAQLSAVLNALIVGRNEGFCAAVREVTDLRLDDRPHWDARRRRFREERDGAPLEGQSAGGWLTVASVGLRDANATVKPGAFDELDASGFLIEVHSAIADLWKDQAMAMSYLRRTHFG
>NC_013947.1|WP_144300614.1|5085186_5086146_+|hypothetical-protein
MTDQPGTESHDEAVSSSAASKSRRKWLIASISAVLLIVAGGAIYATTGIFGNHDGDTPPNGNGSATPEHCRDSSKDTGVSEPESPPMNGGVEVAEDGVNLAKASDIADVTFGVLVENSSDLVARDVTVKMTLKQKSGPTLRNTDGESVVRKSTIPYVMPGKEFGTGEDVRVPIGEVEDAPSVKTEITVGEWWQPNNDVHEFASISATVTNKQDDPDDHINVTVDSQYCDDAGVAKAGVIFRDSAGKIIYGASGFQASSDTADLISGYAPLKNYKPGKTKNLAMPNFWSISTQGAPGAGFEKQPDWEQTEIFPYADSDKG
>NC_013947.1|WP_013020001.1|5083494_5085141_+|hypothetical-protein
MNDLESTDGGHGSGDTSSGLKKLAKDLQRAATDNTIESKQTETTFYFILDDSSGMDITGAKRRPDGTYENGLQGETFIYVPRDSQAWKDVHDSYQPIIDNLVMCGELKYDDLALPLTYMDYVCQALNQGDSKALKELGESIQKGSNKVSDGDIASIKKELTSGNGTWSVADKMGSTLEPWKGRAANVFKVTYMDRLPDILVGQAVLAIALREALNIAKEAFRGAKEDGENLAQAAIDALDAGGASLDATYSEKLKVIANVAGIAAAVTAFAPGTQAFSAVAGLVAASAGAAEYVISKYEKTSGGTDPKIALDAGNVEELMDQVNSRANDIQKAVVDIEYATGEMLYELYLLATSKEVVDIAGASGENAGDLGIELTMRQAYFEPRSPGKESGHGPGMRDFGKQLDDKDKGNDPGYSDFKDEDAMGAIDKGEHMATSIYDLWHAGDTTLPAFAAEYDGAAGDVDSSTTGLSDAFTRPFGGGDDGAGSSTGVLYPEWTRLQEELHTILKNSATNLHLVGKALVAAAIAYAEADGAAAKAIEKDHEDFPKI
>NC_013947.1|WP_013020000.1|5082851_5083310_-|hypothetical-protein
MELRANAVAARIAGVLALVTGCAIGWFALQDIFYLDAGMTGGLTSMVLVNVLGGAVGAGTLLVAAGFTFARRIAGAWTLFGLCLFYAVANTVLAPVLWGVSIGEQLEWIFGFDKANGIAVGVATIFAILTAGAAGIAASMKSVSSQGETARR
>NC_013947.1|WP_013019999.1|5081865_5082876_+|WYL-domain-containing-protein
MIETSSRLLALLALLQSRPHWSGSQLAERLDVTGRTIRNDIDRLRELGYPVDAVRGAGGYYQLGAGAKLPPLLLDDEEAVAVAIGLRAGRGVTGIQESAERALSKLEQVLPHRLRRQVSALTEAVSVGPDDTGTPAPPPDVDAAVLSQIAAAIRDSHLLRFDYTAPDRPDDTPRRNDASAPFADWPVLVEPYRLISWEQHWYLVARGPETGDWHTYRVDWATPRMPTGERFDPVPFPGGDYTAFVLRDVALAGWKVHARITVAAPAEDVLARINPAVGVVEAIDTTTSVLVTGADNLSIIAVYIGMLELDFQVTEPPELVEHVRTLGERYRRAVSP
>NC_013947.1|WP_013019998.1|5080683_5081811_-|epoxide-hydrolase
MTNNNEIRSFRIDIPQADLDDLNDRLARTRLPRPAPTDDWEYGTPNSYLSATVAHWKDEFDWRAQEARMNAFPHYLTEIDGQNIHFIHVPSAEADATPLLLLHTYPGSFADFLDMIGPLTDPVTHGGDAADAFSVVVPSIPGMGFSTPLNGRGWTMRKVAESFDALMRRLGYDSYGAHGSDGGAMISRELGLLEPEGFLGLHVLQLFSFPSGDPAEFAKLGPKDHEALGHMQWFQSVGGYNQMNGTRPQTIGAAIADSPVGQLAYSELFNNFGNGTSLVTTEQILTQVSLYWFTNTQATAGRYHFEEGRAGTEPAVNHSRTGVAVFADDFTTIRAFAERDNSNIVHWSEFPDGGHFAAMERPDVLTGDLRQFFRS
>NC_013947.1|WP_013019997.1|5079752_5080622_+|alpha/beta-hydrolase
MTDPKSHELEVPNAVVTYDVREPAAPSDKPTLLMFASPMEAAAFATLAGHFTDRTVVTYDPRGAGRSKRTDGTSLSTPDEHADDLHRIITELGTGPVDVFASSGGAVNALALVAKHSDQVRTVVAHEPPASQEVPDRENALAACVDIRRTYEASGFGPAMAKFIALVMHKGELPDDYTDQPGPDPAAFGLPTEDDGSRDDPLMGNIVNSNHYKHDFDALRAASTRVVLAVGVESEGELPARAATAVAERLGIEPTMFPSHHAGFTGEESGMAGEPEAFAVRLREVLDQN
>NC_013947.1|WP_052305122.1|5091088_5091898_-|fused-MFS/spermidine-synthase
MNTSEYDAMDLSARIDSGTAELLADPRQDGCWTLVVNGVAQSHVDLYDPLRLDMMYTRMIASILDVIAAPREPLRALHLGGGGMTLPRYLAASRPNSAQLVIERDRPLIEFLHFGLPLPPDCGIAVQHDDARAAVESGADNSFDVVITDAYRGAVMPARVSDTGFVAETARLLAPGGVYIVNVLDAAGLVLTKRQLATVRTAYTDTALLSTPAMWKGRRDGNVVIVAAAESETLPLDRITAAARPRLNLSLKHGPDLDRFLSGTAPVTS
>NC_013947.1|WP_013020008.1|5092066_5092729_+|trypsin-like-serine-protease
MKLARTLTMLAAVVALTAVPTTAVAHEPEARGGVVTAGLPFSTGTTSRCTTGFATEHASLGDGFLAAGHCGSVGDRAYVNNVAVGVVRLRASNGLTWLWVELDDGWTASPALPGGGSITDDRETPIGGSVCRIGSTTGWHCGTVQAKNATVSYPQGTVTGLTRTNVCAEPGDNGGPFVSGSSAQGIALGGSGNCSSGGTTYFYPVRRVFSEAPALSIIGG
>NC_013947.1|WP_013020009.1|5092732_5093584_-|GNAT-family-N-acetyltransferase
MPQLWAPADSIPVRRLDIAELPACLDLAADRGWPREEHKWRLLFDIGEVYGIDDPDGALVGTTVLTRYGPGLCAISMVLVAKRFDGHGLGRRMMTQVLAHTGDAVVTLYATSFGLPLYQKLGFTVVSDNVTHIGEFTGTDAPERSRPATAADLPAIERLDAEVHGADRSVLVRRLPDFCSQLRVIEADGAITGYAGAWVNLDKVVAGPVVAASADDAKTLLTDLARAIKSPIRLEILHEFGELGAWAVEHGLVPGTATSFMVHGGRELPGDAARRFTPVSVAL
>NC_013947.1|WP_013020010.1|5093741_5094752_+|threonine/serine-dehydratase
MITKADVDAAAARIAGRVRTTPVMTVEPGVFGPAVVLKCEYTQHTGTFKARGAFNRILSAAEPTLGSGSGSGSGSGSGSGDSMTGAQRERLGPAGVVAASGGNAGLAVAYAAAQLGVAATVFVPETAPAVKVNKLRALGAVVRQVGSEFALANEAALAHAAETGALLCHAYDQPEIVAGQGTLAIELLGQAPDVDTVLVSVGGGGLAGGIAAGLDGRAKLVAVEPETIPTLHTALSKGGPVDVEVSGVAADSLGARRIGDIAYELAVRHGVHSVLVDDASIIAARKLLWDKLRIVVEHGTAAALAALATGAYQPAPNESVAVILCGANTDPSDINA
>NC_013947.1|WP_013020011.1|5095196_5095850_-|hypothetical-protein
MTILTHLGPVLTRAELSTRGWTRSMVIELLDPPDQRKPNPFYRSSTPMYLYRLERVEQAEAGAEFARLSRRARLRSAQAKATAQRRRDALLAEVRSASITLPSLTRAELAEAAVRHRNKREEQRCYLVPDRHFEPATVDDIDPVTLARWQVDYLRRRQTGYDQLMSAVTGRVGRADATRAIRAKLYNAIATAYPSLRRECDRQLRLPDIPDHASRAH
>NC_013947.1|WP_013020012.1|5095930_5096401_-|hypothetical-protein
MTESKFLMDDVRGFRHAEDLIRQVVDELRPRFHVKPGLRNSMPELDEDEELNEADENRDVQRMTNVEVTYSLEPGTTEPAPDNASVFGQVETLWQRRGYDTLIRVVDPPPRRLCVRDPRDGFTISINEGQAGNLWLTAASGPVVYTQATPPPPGIF
>NC_013947.1|WP_013020013.1|5096397_5097978_-|hypothetical-protein
MVDYPALEGCEPGGFDRAAQEAGELAQNVESMIDELEALVPVLSGADDDFATVNAIRDRVAAETDRLREAQLSLRTIETSLLSLGEDVRRGRMELEEARRRADKFAKVDYSLGVITLDFGKVPQADADPKGFARFKAQLRDVADQMRRAHTLANTSDYDAASDIAKKSPALTEPGPSRIRSPYENHSWWTGRSAAEREHRIETEPNLVGGPDSDGIPSAARSAANEQLLRQHIRELEERAASGSGAASRLLAVMLAVQHRLADDASDGTRERAFLLLAEPSDPGRIVLAIGNPDIADHVIVHIPGTGASLPKLAGEIARVERMVGDANLYETRHTAGILWLGYDAPPNLFAAATKRYAQSATKPLPRFLTGIRAVRRRGLDRFGVTVMGHSYGTVAIGFTVREQQVSASQLILVASPGVGVKSADQLKIDKDDVYATTAPNDIIHRVPRVPHGTSPVHKSFGAKVFPTPHHNGSQIAAHSAYWKNDNPVRQDFAAIITGHGHKVVGGTDADVRIQPGPWTNDEGGE
>NC_013947.1|WP_013020014.1|5097996_5098302_-|hypothetical-protein
MRFDVSLMRARARNIEKLSETALACARRSEDGLNIENNDGFDTVAEVRTVRGELTELLESISGELKAAAVDLKNFADEVEGVDLDNADELRRFDEEPPMPE
>NC_013947.1|WP_144300845.1|5098499_5100674_-|M6-family-metalloprotease-domain-containing-protein
MVATASPTDETTQDKSSKKSSSLHGEDLPKTPLQLEREENQKAAAQKVAQGKAKSSDRSVKLEDGEFGEFGTGSGDEIFTLLVEFGDKVSEHGGDKGPLRNEIPEPDRKKDNSTSWKSDYTQEYYQEMLFGEGYSMTDFYEKQSGGQYTVDGTVEDWVKLPYNEARYGYNENEAEAYGAFVTDSAQAWYDAQIESGKSKEDIQDYLGQFDRQDRYDFDFDGDFDEPDGYVDHIQIIHAGEGEEAGGGAQGEDAIWSHRWFAQTNLAGPDSNPVGGAPLGDSGIWVGDYTTEPENGGLGVFTHEFGHDLGLPDLYATQGAANSTGRWTLMSGGSWLNDGKKEIGNRPGYMGPWEKWFLGWLDYDEVEMNQNSKVSKLGAAGKPGSLNAATKVNLPDETEEREYAKPSSGEYEWMFGEGDDLNSSLSRELDLTAAKDKAEFTANTFLDTEEGYDYFFAEVSTDGGKWKRVGDKHSGSSGEFKELKFDLSEYAGQKVQFRMRYQTDGNTHGTGVFVDDLAVVADGEKVWSDDVEGGDNGWTGYGAKRTTGKETLTFARFYLVENRQHVSYDKFLKTGPYNFGFANTKPDWVERYRYEEGMLVWFVNTKFGDNNTGLHPGQGLALPVDAHAKPLKWSNGQLVHPTHQSFDSPFSLNKTKEVTLHLNGKKKIFVSQKGVGVFDDSDPEAYWSKDLPNSSVKVAGEGIKVKILDMGDDEGAPMKIQITRS
>NC_013947.1|WP_144300615.1|5101084_5101462_+|hypothetical-protein
MVPQGDRRSRFEARLRDVETELARLRGVRDTMVAAGARARELAATLAADTVASTSDDGVATVSCDGRGHVDTVVFDRAGYNRIDEKQLCDSVLQARYRARDRARRESAAVGRDLFHGDSGAATGV

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Crispr_ID: NC_013947_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_13

5094969-5095047

Orphan

Consensus_repeat	Method
GGCGTGCTCGGCGATCAAGCTCGGCGATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_13

>merge|NC_013947|13|5094969-5095047|CRISPRCasFinder
GGCGTGCTCGGCGATCAAGCTCGGCGATCAAGCTCAGCGGTCGTCCGCCAGCGGCGATCGGCAGGCGTGCTCGGCGATC

>NC_013947|13|12|5094969-5095047|CRISPRCasFinder
GGCGTGCTCGGCGATCAAGCTCGGCGATC	AAGCTCAGCGGTCGTCCGCCA
GCGGCGATCGGCAGGCGTGCTCGGCGATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013020004.1\|5086849_5087314_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239316
NC_013947.1\|WP_013020018.1\|5101805_5102807_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020001.1\|5083494_5085141_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020017.1\|5101467_5101797_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NC_013947.1\|WP_013020009.1\|5092732_5093584_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|380091
NC_013947.1\|WP_013020012.1\|5095930_5096401_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020011.1\|5095196_5095850_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020019.1\|5102841_5104002_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NC_013947.1\|WP_052305122.1\|5091088_5091898_-\|fused-MFS/spermidine-synthase	unknown	unknown	gnl\|CDD\|179854
NC_013947.1\|WP_013020013.1\|5096397_5097978_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|283837
NC_013947.1\|WP_013020014.1\|5097996_5098302_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300615.1\|5101084_5101462_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300614.1\|5085186_5086146_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183743
NC_013947.1\|WP_013020020.1\|5104106_5105030_+\|ACP-S-malonyltransferase	unknown	unknown	gnl\|CDD\|223408
NC_013947.1\|WP_013020003.1\|5086169_5086676_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020005.1\|5087360_5087783_-\|DUF3052-domain-containing-protein	unknown	unknown	gnl\|CDD\|378615
NC_013947.1\|WP_144300845.1\|5098499_5100674_-\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|368494
NC_013947.1\|WP_086013330.1\|5088018_5090760_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl\|CDD\|236500
NC_013947.1\|WP_013020010.1\|5093741_5094752_+\|threonine/serine-dehydratase	unknown	unknown	gnl\|CDD\|181319
NC_013947.1\|WP_013020008.1\|5092066_5092729_+\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|365866

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013020004.1\|5086849_5087314_-\|peroxiredoxin	gnl\|CDD\|239316	cd03018, PRX_AhpE_like, Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater similarity to 2-cys PRXs than 1-cys PRXs. PRXs are thiol-specific antioxidant (TSA) proteins that confer a protective role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. The first step of catalysis is the nucleophilic attack by the peroxidatic cysteine on the peroxide leading to the formation of a cysteine sulfenic acid intermediate. The absence of a resolving cysteine suggests that functional AhpE is regenerated by an external reductant. The solution behavior and crystal structure of AhpE show that it forms dimers and octamers.	1.66476e-76
NC_013947.1\|WP_013020009.1\|5092732_5093584_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|380091	pfam18014, Acetyltransf_18, Acetyltransferase (GNAT) domain. This entry represents a likely acetyltransferase enzyme that is related to pfam06852.	9.26481e-17
NC_013947.1\|WP_013020017.1\|5101467_5101797_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	2.28858e-06
NC_013947.1\|WP_013020019.1\|5102841_5104002_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	2.39052e-15
NC_013947.1\|WP_052305122.1\|5091088_5091898_-\|fused-MFS/spermidine-synthase	gnl\|CDD\|179854	PRK04457, PRK04457, polyamine aminopropyltransferase.	1.52527e-10
NC_013947.1\|WP_013020013.1\|5096397_5097978_-\|hypothetical-protein	gnl\|CDD\|283837	pfam06259, Abhydrolase_8, Alpha/beta hydrolase. Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile.	5.7268e-19
NC_013947.1\|WP_144300614.1\|5085186_5086146_+\|hypothetical-protein	gnl\|CDD\|183743	PRK12785, fliL, flagellar basal body-associated protein FliL; Reviewed.	0.00163162
NC_013947.1\|WP_013020020.1\|5104106_5105030_+\|ACP-S-malonyltransferase	gnl\|CDD\|223408	COG0331, FabD, (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism].	3.83932e-74
NC_013947.1\|WP_013020005.1\|5087360_5087783_-\|DUF3052-domain-containing-protein	gnl\|CDD\|378615	pfam11253, DUF3052, Protein of unknown function (DUF3052). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.36642e-56
NC_013947.1\|WP_144300845.1\|5098499_5100674_-\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|368494	pfam05547, Peptidase_M6, Immune inhibitor A peptidase M6. The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.	3.15288e-159
NC_013947.1\|WP_086013330.1\|5088018_5090760_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl\|CDD\|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NC_013947.1\|WP_013020010.1\|5093741_5094752_+\|threonine/serine-dehydratase	gnl\|CDD\|181319	PRK08246, PRK08246, serine/threonine dehydratase.	1.27223e-140
NC_013947.1\|WP_013020008.1\|5092066_5092729_+\|trypsin-like-serine-protease	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	0.00262675

>NC_013947.1|WP_013020010.1|5093741_5094752_+|threonine/serine-dehydratase
MITKADVDAAAARIAGRVRTTPVMTVEPGVFGPAVVLKCEYTQHTGTFKARGAFNRILSAAEPTLGSGSGSGSGSGSGSGDSMTGAQRERLGPAGVVAASGGNAGLAVAYAAAQLGVAATVFVPETAPAVKVNKLRALGAVVRQVGSEFALANEAALAHAAETGALLCHAYDQPEIVAGQGTLAIELLGQAPDVDTVLVSVGGGGLAGGIAAGLDGRAKLVAVEPETIPTLHTALSKGGPVDVEVSGVAADSLGARRIGDIAYELAVRHGVHSVLVDDASIIAARKLLWDKLRIVVEHGTAAALAALATGAYQPAPNESVAVILCGANTDPSDINA
>NC_013947.1|WP_013020009.1|5092732_5093584_-|GNAT-family-N-acetyltransferase
MPQLWAPADSIPVRRLDIAELPACLDLAADRGWPREEHKWRLLFDIGEVYGIDDPDGALVGTTVLTRYGPGLCAISMVLVAKRFDGHGLGRRMMTQVLAHTGDAVVTLYATSFGLPLYQKLGFTVVSDNVTHIGEFTGTDAPERSRPATAADLPAIERLDAEVHGADRSVLVRRLPDFCSQLRVIEADGAITGYAGAWVNLDKVVAGPVVAASADDAKTLLTDLARAIKSPIRLEILHEFGELGAWAVEHGLVPGTATSFMVHGGRELPGDAARRFTPVSVAL
>NC_013947.1|WP_013020008.1|5092066_5092729_+|trypsin-like-serine-protease
MKLARTLTMLAAVVALTAVPTTAVAHEPEARGGVVTAGLPFSTGTTSRCTTGFATEHASLGDGFLAAGHCGSVGDRAYVNNVAVGVVRLRASNGLTWLWVELDDGWTASPALPGGGSITDDRETPIGGSVCRIGSTTGWHCGTVQAKNATVSYPQGTVTGLTRTNVCAEPGDNGGPFVSGSSAQGIALGGSGNCSSGGTTYFYPVRRVFSEAPALSIIGG
>NC_013947.1|WP_052305122.1|5091088_5091898_-|fused-MFS/spermidine-synthase
MNTSEYDAMDLSARIDSGTAELLADPRQDGCWTLVVNGVAQSHVDLYDPLRLDMMYTRMIASILDVIAAPREPLRALHLGGGGMTLPRYLAASRPNSAQLVIERDRPLIEFLHFGLPLPPDCGIAVQHDDARAAVESGADNSFDVVITDAYRGAVMPARVSDTGFVAETARLLAPGGVYIVNVLDAAGLVLTKRQLATVRTAYTDTALLSTPAMWKGRRDGNVVIVAAAESETLPLDRITAAARPRLNLSLKHGPDLDRFLSGTAPVTS
>NC_013947.1|WP_086013330.1|5088018_5090760_+|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MTNERKRPVISDGLPSQLPDIDPQETAEWLESLDGLVDEQGRQRARYVMLRMLERARESQVGVPALTSTDYINSIPPEAEPWFPGDEHVERRIRAYIRWNAAMMVHRAQRPGIGVGGHISTYASAASLYEVGFNHFFKGKQHAGGGDQIYIQGHGSPGIYARAYLEGRLTEHQMDGFRQELSHPGGGLPSYPHPRLMPDFWEFPTVSMGLGPQGAIYQAQFNRYLQHRGIKDTSQQRVWAFLGDGEMDEPESLGAIHLAAREELDNLTFVVNCNLQRLDGPVRGNGKIIQELESFFRGAGWNVIKVIWGREWDSLLAADTDGALVNIMNSTPDGDYQTFKAEDGGFVREHFFGRDPRTKRMVEPLTDEQVWNLKRGGHDYRKLFAAYKAATEHTGQPTVILAKTIKGWTLGSHFEGRNATHQMKKLTLDDLKSFRDRLYLDIPDSALEENPYLPPYFHPGKGSDEIEYMMERRKSLGGPVPTRRTKHKALELPPSSTYDVVKKGSGKQKVATTMAFVRLLKDLMKDKNIGPRWVPIIPDEARTFGMDAMFPTSKIYSPHGQNYLSVDRDLFLSYKEAEKGQILHLGINESGSSSAFIAAGTSYATHDEPMIPMYIFYSMFGFQRTGDHLWAAADQMTRGFLLGATAGRTTLNGEGLQHEDGHSPLLAATNPAVLTYDPAFGYEVAHIVEDGLRRMYGEKQENIFYYLTVYNEPITQPAQPDGLDVNGVLKGIYKYRSAADNANLPKVRLLASGVSMQWALKAAELLAADWGVSADVYSVTSWTELRRDAVACEEANLLNPDAEEQVPFITQQLSDGSGPVVAVSDFMRAVPDLISRWVPGEYTSLGTDGFGQSDTRGALRRHFHVDGESIAVAALRQLARRGDLPTEAAAQAARKYAIEDVSAAEAGETGGDS
>NC_013947.1|WP_013020005.1|5087360_5087783_-|DUF3052-domain-containing-protein
MSATAGSADGVRTIIDKLGIDTDAVVMEIGFDSDIDSALREAVIARVGELHDEDTDEVVDVVLLWWRDEDGDLVDVLMDARSPLSEEGVVWLLTPKPGRDGHIESAEISEAAPTAGLSSTSSVNAGEDWVATRLVAPRGR
>NC_013947.1|WP_013020004.1|5086849_5087314_-|peroxiredoxin
MTVAVGTQAPDFTLKDQNNQEVTLSSFKGHKNVLLVFYPLAFTGVCEGELCGVRDNLSSYQSDEVQVLTVSVDSVFTHKVWADKEGFEFPLLSDFWPHGGVAKTFGVFDEDKGIANRGTFVIDTTGTVRFAEMNLPGEPRDQGAWQKALAELTG
>NC_013947.1|WP_013020003.1|5086169_5086676_+|hypothetical-protein
MGRLADTLDALSVRALSPDHRIQGQLHHRTKVDISFTSEDSYYEYKSEQAVAAQLSAVLNALIVGRNEGFCAAVREVTDLRLDDRPHWDARRRRFREERDGAPLEGQSAGGWLTVASVGLRDANATVKPGAFDELDASGFLIEVHSAIADLWKDQAMAMSYLRRTHFG
>NC_013947.1|WP_144300614.1|5085186_5086146_+|hypothetical-protein
MTDQPGTESHDEAVSSSAASKSRRKWLIASISAVLLIVAGGAIYATTGIFGNHDGDTPPNGNGSATPEHCRDSSKDTGVSEPESPPMNGGVEVAEDGVNLAKASDIADVTFGVLVENSSDLVARDVTVKMTLKQKSGPTLRNTDGESVVRKSTIPYVMPGKEFGTGEDVRVPIGEVEDAPSVKTEITVGEWWQPNNDVHEFASISATVTNKQDDPDDHINVTVDSQYCDDAGVAKAGVIFRDSAGKIIYGASGFQASSDTADLISGYAPLKNYKPGKTKNLAMPNFWSISTQGAPGAGFEKQPDWEQTEIFPYADSDKG
>NC_013947.1|WP_013020001.1|5083494_5085141_+|hypothetical-protein
MNDLESTDGGHGSGDTSSGLKKLAKDLQRAATDNTIESKQTETTFYFILDDSSGMDITGAKRRPDGTYENGLQGETFIYVPRDSQAWKDVHDSYQPIIDNLVMCGELKYDDLALPLTYMDYVCQALNQGDSKALKELGESIQKGSNKVSDGDIASIKKELTSGNGTWSVADKMGSTLEPWKGRAANVFKVTYMDRLPDILVGQAVLAIALREALNIAKEAFRGAKEDGENLAQAAIDALDAGGASLDATYSEKLKVIANVAGIAAAVTAFAPGTQAFSAVAGLVAASAGAAEYVISKYEKTSGGTDPKIALDAGNVEELMDQVNSRANDIQKAVVDIEYATGEMLYELYLLATSKEVVDIAGASGENAGDLGIELTMRQAYFEPRSPGKESGHGPGMRDFGKQLDDKDKGNDPGYSDFKDEDAMGAIDKGEHMATSIYDLWHAGDTTLPAFAAEYDGAAGDVDSSTTGLSDAFTRPFGGGDDGAGSSTGVLYPEWTRLQEELHTILKNSATNLHLVGKALVAAAIAYAEADGAAAKAIEKDHEDFPKI
>NC_013947.1|WP_013020011.1|5095196_5095850_-|hypothetical-protein
MTILTHLGPVLTRAELSTRGWTRSMVIELLDPPDQRKPNPFYRSSTPMYLYRLERVEQAEAGAEFARLSRRARLRSAQAKATAQRRRDALLAEVRSASITLPSLTRAELAEAAVRHRNKREEQRCYLVPDRHFEPATVDDIDPVTLARWQVDYLRRRQTGYDQLMSAVTGRVGRADATRAIRAKLYNAIATAYPSLRRECDRQLRLPDIPDHASRAH
>NC_013947.1|WP_013020012.1|5095930_5096401_-|hypothetical-protein
MTESKFLMDDVRGFRHAEDLIRQVVDELRPRFHVKPGLRNSMPELDEDEELNEADENRDVQRMTNVEVTYSLEPGTTEPAPDNASVFGQVETLWQRRGYDTLIRVVDPPPRRLCVRDPRDGFTISINEGQAGNLWLTAASGPVVYTQATPPPPGIF
>NC_013947.1|WP_013020013.1|5096397_5097978_-|hypothetical-protein
MVDYPALEGCEPGGFDRAAQEAGELAQNVESMIDELEALVPVLSGADDDFATVNAIRDRVAAETDRLREAQLSLRTIETSLLSLGEDVRRGRMELEEARRRADKFAKVDYSLGVITLDFGKVPQADADPKGFARFKAQLRDVADQMRRAHTLANTSDYDAASDIAKKSPALTEPGPSRIRSPYENHSWWTGRSAAEREHRIETEPNLVGGPDSDGIPSAARSAANEQLLRQHIRELEERAASGSGAASRLLAVMLAVQHRLADDASDGTRERAFLLLAEPSDPGRIVLAIGNPDIADHVIVHIPGTGASLPKLAGEIARVERMVGDANLYETRHTAGILWLGYDAPPNLFAAATKRYAQSATKPLPRFLTGIRAVRRRGLDRFGVTVMGHSYGTVAIGFTVREQQVSASQLILVASPGVGVKSADQLKIDKDDVYATTAPNDIIHRVPRVPHGTSPVHKSFGAKVFPTPHHNGSQIAAHSAYWKNDNPVRQDFAAIITGHGHKVVGGTDADVRIQPGPWTNDEGGE
>NC_013947.1|WP_013020014.1|5097996_5098302_-|hypothetical-protein
MRFDVSLMRARARNIEKLSETALACARRSEDGLNIENNDGFDTVAEVRTVRGELTELLESISGELKAAAVDLKNFADEVEGVDLDNADELRRFDEEPPMPE
>NC_013947.1|WP_144300845.1|5098499_5100674_-|M6-family-metalloprotease-domain-containing-protein
MVATASPTDETTQDKSSKKSSSLHGEDLPKTPLQLEREENQKAAAQKVAQGKAKSSDRSVKLEDGEFGEFGTGSGDEIFTLLVEFGDKVSEHGGDKGPLRNEIPEPDRKKDNSTSWKSDYTQEYYQEMLFGEGYSMTDFYEKQSGGQYTVDGTVEDWVKLPYNEARYGYNENEAEAYGAFVTDSAQAWYDAQIESGKSKEDIQDYLGQFDRQDRYDFDFDGDFDEPDGYVDHIQIIHAGEGEEAGGGAQGEDAIWSHRWFAQTNLAGPDSNPVGGAPLGDSGIWVGDYTTEPENGGLGVFTHEFGHDLGLPDLYATQGAANSTGRWTLMSGGSWLNDGKKEIGNRPGYMGPWEKWFLGWLDYDEVEMNQNSKVSKLGAAGKPGSLNAATKVNLPDETEEREYAKPSSGEYEWMFGEGDDLNSSLSRELDLTAAKDKAEFTANTFLDTEEGYDYFFAEVSTDGGKWKRVGDKHSGSSGEFKELKFDLSEYAGQKVQFRMRYQTDGNTHGTGVFVDDLAVVADGEKVWSDDVEGGDNGWTGYGAKRTTGKETLTFARFYLVENRQHVSYDKFLKTGPYNFGFANTKPDWVERYRYEEGMLVWFVNTKFGDNNTGLHPGQGLALPVDAHAKPLKWSNGQLVHPTHQSFDSPFSLNKTKEVTLHLNGKKKIFVSQKGVGVFDDSDPEAYWSKDLPNSSVKVAGEGIKVKILDMGDDEGAPMKIQITRS
>NC_013947.1|WP_144300615.1|5101084_5101462_+|hypothetical-protein
MVPQGDRRSRFEARLRDVETELARLRGVRDTMVAAGARARELAATLAADTVASTSDDGVATVSCDGRGHVDTVVFDRAGYNRIDEKQLCDSVLQARYRARDRARRESAAVGRDLFHGDSGAATGV
>NC_013947.1|WP_013020017.1|5101467_5101797_+|YbaB/EbfC-family-nucleoid-associated-protein
METHSDPAEPRSRQDAKLSKARVAASSPKGVVTVVYNGHGDGLSLELKPGAKQRYESETMAGFVTAALRAADRAVDALRQHAVDDRDDDTRPSRAAANMDVARCFGRAT
>NC_013947.1|WP_013020018.1|5101805_5102807_+|hypothetical-protein
MNDSMTAVLATLPERLRRAADRLWRHSSEATDEVTETLTVSYQVLRRVCGDPESIAVAGDLLSTVVAAEIGAARGAIDTAGPQVTRAWQGTGAESFGEYLPRLSATLAAVEDGARDTAEAVALFGSGVASLYAAVVERTEATDAEVAATVAATRQTPHEAVGPVIDLVAEYSEYVEELATALVNLTSDSHPAGQRLALAAELPAGITDGHRLPRLDLAGDFHPAHDQVALDTAAMARLTSCLSDTGGHWARAGDSAASAAERLTPESLGLAGSHFCDDVHSVLERDRGLYATVTGQLDDLALGLRRVSSAYVTADDEIAAELRRGLEGPDADR
>NC_013947.1|WP_013020019.1|5102841_5104002_+|helix-turn-helix-domain-containing-protein
MELAATIQKIERAASALATQSVARMDAELPWFRELPAEQRAMVTLVAQAGVGSFVEWLRGDGEAPAVGDEVFDGAPRELARLIRLQHTVALIKVTIDVVEEQVPHLAAPGEEEALHIAVLKFSREVAFGAARVYARTAETRGAWDARLQAMLVDGLLRGDDGDEIAGRAAALGWGDSSPVAVVVGRSPGGEAAVILHAVHRATRRMGIDVVAGVHGERLILVLGGSTEPEEVAGKLVGQFGEGPIVVGPATPSLAEAGASARAALSGHRAAPAWPGAPRPVSAHQLLAERALAGDNEARRILRIDVYNALERAGGSLLSTVDTFIATGGVLEGTARAVFVHPNTIRYRMRRVAEVTGFSPFVPHDAFTLHVALTIGRLDPTSDVIR
>NC_013947.1|WP_013020020.1|5104106_5105030_+|ACP-S-malonyltransferase
MLSVLAPGQGSQKPGFLIPWLELPGVAERLGSWSELIGIDLVHLGTTATQEEITDTAKTQPLLTAAALLAAEQLPIEDVDLVAGHSVGELGASVMAGVLTPEAALRLATARGREMAAACALTPTGMSAVLGGDDQVVREAIEQAGAYPANINGAGQVVAAGTTEALARLADNPPPGARVRSLSVAGAFHTPYMKPAQAKLTAFASTLEPADPERTWLSNADGSAMESGNQALLRLVAQVTTSVRWDECMKTMTKLGVTAIVELPPAGTLAGLAKRAMPGMEIVKVNTPDDLEAARDLINRNRKERTA

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Crispr_ID: NC_013947_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_14

5194459-5194527

Orphan

Consensus_repeat	Method
CTCGCCCTCACCGGACTTGTCGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_14

>merge|NC_013947|14|5194459-5194527|CRISPRCasFinder
CTCGCCCTCACCGGACTTGTCGTCCTCGGTCTTCTCGCCACCGGACTCGCCCTCGCCCGACTTCTCGCC

>NC_013947|14|13|5194459-5194527|CRISPRCasFinder
CTCGCCCTCACCGGACTTGTCGTC	CTCGGTCTTCTCGCCACCGGA
CTCGCCCTCGCCCGACTTCTCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013020109.1\|5202747_5203140_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319939
NC_013947.1\|WP_144300848.1\|5182885_5183635_+\|ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377145
NC_013947.1\|WP_013020096.1\|5188517_5189255_-\|chitinase	unknown	unknown	gnl\|CDD\|381595
NC_013947.1\|WP_013020110.1\|5203338_5203623_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368199
NC_013947.1\|WP_013020107.1\|5200672_5201098_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NC_013947.1\|WP_052305319.1\|5192676_5194008_-\|aspartate--tRNA(Asn)-ligase	unknown	unknown	gnl\|CDD\|235354
NC_013947.1\|WP_013020112.1\|5205354_5206020_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_013947.1\|WP_144300849.1\|5186491_5188129_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_013947.1\|WP_013020104.1\|5195534_5198804_-\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|227282
NC_013947.1\|WP_013020094.1\|5184924_5186406_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|312032
NC_013947.1\|WP_041625139.1\|5190979_5191867_-\|glutamate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270408
NC_013947.1\|WP_013020098.1\|5189903_5190887_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|349754
NC_013947.1\|WP_144300850.1\|5199930_5200590_+\|DUF4191-family-protein	unknown	unknown	gnl\|CDD\|379389
NC_013947.1\|WP_052305318.1\|5183754_5184801_+\|acyl-CoA-desaturase	unknown	unknown	gnl\|CDD\|239583
NC_013947.1\|WP_083787211.1\|5191865_5192633_+\|lipoyl(octanoyl)-transferase-LipB	unknown	unknown	gnl\|CDD\|184638
NC_013947.1\|WP_083787212.1\|5198876_5199866_+\|lipoyl-synthase	unknown	unknown	gnl\|CDD\|235493
NC_013947.1\|WP_013020103.1\|5195038_5195425_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020097.1\|5189439_5189838_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_041625143.1\|5201273_5202698_+\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|273198
NC_013947.1\|WP_144300626.1\|5203615_5205358_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_144300848.1\|5182885_5183635_+\|ANTAR-domain-containing-protein	gnl\|CDD\|377145	pfam03861, ANTAR, ANTAR domain. ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	1.41063e-13
NC_013947.1\|WP_013020096.1\|5188517_5189255_-\|chitinase	gnl\|CDD\|381595	cd00325, chitinase_GH19, Glycoside hydrolase family 19, chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Glycoside hydrolase family 19 chitinases are found primarily in plants (classes I, III, and IV), but some are found in bacteria. Class I and II chitinases are similar in their catalytic domains. Class I chitinases have an N-terminal cysteine-rich, chitin-binding domain which is separated from the catalytic domain by a proline and glycine-rich hinge region. Class II chitinases lack both the chitin-binding domain and the hinge region. Class IV chitinases are similar to class I chitinases, but they are smaller in size due to certain deletions. Despite lacking any significant sequence homology with lysozymes, structural analysis reveals that family 19 chitinases, together with family 46 chitosanases, are similar to several lysozymes including those from T4-phage and from goose. The structures reveal that the different enzyme groups arose from a common ancestor glycohydrolase antecedent to the prokaryotic/eukaryotic divergence.	2.65047e-84
NC_013947.1\|WP_013020110.1\|5203338_5203623_+\|hypothetical-protein	gnl\|CDD\|368199	pfam04931, DNA_pol_phi, DNA polymerase phi. This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.	0.00307621
NC_013947.1\|WP_013020107.1\|5200672_5201098_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	5.81748e-14
NC_013947.1\|WP_052305319.1\|5192676_5194008_-\|aspartate--tRNA(Asn)-ligase	gnl\|CDD\|235354	PRK05159, aspC, aspartyl-tRNA synthetase; Provisional.	0
NC_013947.1\|WP_013020112.1\|5205354_5206020_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.83854e-81
NC_013947.1\|WP_144300849.1\|5186491_5188129_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	3.88889e-136
NC_013947.1\|WP_013020104.1\|5195534_5198804_-\|S41-family-peptidase	gnl\|CDD\|227282	COG4946, COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown].	5.71546e-147
NC_013947.1\|WP_013020094.1\|5184924_5186406_+\|alpha/beta-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	5.85685e-16
NC_013947.1\|WP_041625139.1\|5190979_5191867_-\|glutamate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.282e-102
NC_013947.1\|WP_013020098.1\|5189903_5190887_-\|ATP-binding-protein	gnl\|CDD\|349754	cd02034, CooC1, accessory protein CooC1. The accessory protein CooC1, a nickel-binding ATPase, participates in the incorporation of nickel into the complex active site ([Ni-4Fe-4S]) cluster of Ni,Fe-dependent carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible oxidation of CO to CO2. CODH contains a nickel-iron-sulfur cluster (C-center) and an iron-sulfur cluster (B-center). CO oxidation occurs at the C-center. Three accessory proteins encoded by cooCTJ genes are involved in nickel incorporation into a nickel site. CooC functions as a nickel insertase that mobilizes nickel to apoCODH using energy released from ATP hydrolysis. CooC is a homodimer and has NTPase activities. Mutation at the P-loop abolishs its function.	1.1876e-28
NC_013947.1\|WP_144300850.1\|5199930_5200590_+\|DUF4191-family-protein	gnl\|CDD\|379389	pfam13829, DUF4191, Domain of unknown function (DUF4191).	2.99825e-86
NC_013947.1\|WP_052305318.1\|5183754_5184801_+\|acyl-CoA-desaturase	gnl\|CDD\|239583	cd03506, Delta6-FADS-like, The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity. While HUFAs may be required for cold tolerance in bacteria, plants and fish, the primary role of HUFAs in mammals is cell signaling. These enzymes are described as front-end desaturases because they introduce a double bond between the pre-exiting double bond and the carboxyl (front) end of the fatty acid. Various substrates are involved, with both acyl-coenzyme A (CoA) and acyl-lipid desaturases present in this CD. Acyl-lipid desaturases are localized in the membranes of cyanobacterial thylakoid, plant endoplasmic reticulum (ER), and plastid; and acyl-CoA desaturases are present in ER membrane. ER-bound plant acyl-lipid desaturases and acyl-CoA desaturases require cytochrome b5 as an electron donor. Most of the eukaryotic desaturase domains have an adjacent N-terminal cytochrome b5-like domain. This domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain the residues: HXXXH, HXX(X)HH, and Q/HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homolog, stearoyl CoA desaturase.	2.44024e-63
NC_013947.1\|WP_083787211.1\|5191865_5192633_+\|lipoyl(octanoyl)-transferase-LipB	gnl\|CDD\|184638	PRK14345, PRK14345, lipoyl(octanoyl) transferase LipB.	1.28294e-115
NC_013947.1\|WP_013020109.1\|5202747_5203140_-\|VOC-family-protein	gnl\|CDD\|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	9.26435e-66
NC_013947.1\|WP_144300626.1\|5203615_5205358_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.7275e-54
NC_013947.1\|WP_083787212.1\|5198876_5199866_+\|lipoyl-synthase	gnl\|CDD\|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	0
NC_013947.1\|WP_041625143.1\|5201273_5202698_+\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0

>NC_013947.1|WP_052305319.1|5192676_5194008_-|aspartate--tRNA(Asn)-ligase
MTAPSPAAPTTPPRVLSAALSEHVGARIRIAGWLHRRRLLKSVAFAIVRDRSGLAQVVVSEEVARARLEELNEETVVEVTGTVVANPAAPGGVELVEPVITVLGEAEAPPFDLYRPSLRATLPTLLDRAPVSLRHPRRKAAFELASAATMGFRETVAAMDFTEIFTPKIVASATESGANVFAIDYFGRPGYLAQSPQFYKQTMVGVFERVFEVGPVFRAEPHDTVRHLAEYTSLDVEFGFIESYRDVAEVLREVVAGMVSAVAERAAAAVALLEPVVPQVPSRFPELHFAEALELISRETGEDLSGVNDLSPAHERWVGEWARREHGSDFAVVVGYPMSKRPFYTAEDPGRPGYSDSFDLLFRGTEMVTGGRRLHRYADYLAAIAAQGGSPEPYAGYLEAFKHGMPPHGGFAIGLERFVAQLTGVANIREVTLFPRDLHRIAP
>NC_013947.1|WP_083787211.1|5191865_5192633_+|lipoyl(octanoyl)-transferase-LipB
MRRTGVPFTARGSRTSTIRVTRDRLHPAKPRGDPSARTRLGGVSDTRARTLKIDRLGTVDYARAWDLQKDLQDKRINDEIDDTVLLLEHPSVYTAGRRTEKWTYPDDGTPVVEVDRGGQITWHGPGQLVGYPIVKLTKPIDVVKYVRRVEDMLMAVCGEFGVATTRIDDRTGVWIPADDRGPERKIASIGVRVRWAVTLHGFALNCDNDMSFFDHIVPCAIMDKDMTSLSRETGRDVTVDEVIPVTEKHMHLILD
>NC_013947.1|WP_041625139.1|5190979_5191867_-|glutamate-ABC-transporter-substrate-binding-protein
MRRAVLAVAVLSVAVATGCQADTVDDTVPPFYNIDQAERSEMPKEVRDILDSGRLTIGSKFDQPLTGLRDKATGRIEGFDAEIGRIITQRIFGKVAEGENLDFIETVPANREKYLEDGTVDLVLATYTITPERKKAVTFAGPYYEAGQAIMTRKGEGIEDIKDLSKKKVCAAEGTTSLDNVEKHNPRANVSKPMRNWSSCRQALLEKEYDAVSTDDVILYGFLSEDPSKLEISKKTFTTEPYGIGLPKGSTELQKFINETLELAFDNGDWQTAFDSTLAVAEVPDPESPPNITEK
>NC_013947.1|WP_013020098.1|5189903_5190887_-|ATP-binding-protein
MKIAFVGKGGSGKTTLASLFARRAVAAGHPVFAIDADINQHLAAALGVDEDTAAKLPKLGDHLAEIKEYLRGDNPRIASAEAMVKTTPPGSGSRLLTIGEDNPVYDACVRNLAGLRLAVTGGFAEDDLGVACYHSKVGAVELMLNHLVDGPGEYVIVDMVAGAEAFASGLFTRFDRTFLVCEPTVRSVGVYKQYAEYAADYDVAISVIGNKIDEPEDVDFLREHVGDALFGWCGRSKFVKAAERGSVGPIADLEPENLALLDRARELVELGGKDWARFSEQARLFHRRNAEAWGNSRMGVDLSEQIDPDFVLGPDSTTDTRGMAKVS
>NC_013947.1|WP_013020097.1|5189439_5189838_-|hypothetical-protein
MSLDVSAELLDKAERGEVSDAEFVDCVRTSLPFAWSMISRVVGDLRDGDPTAEFADNVTPPPDEAARGQLLRALASDAIRGGLERHFGVKLAFQNCHRVAAFRINSVDGDRYRKFISPVGQLRNQSPELRDC
>NC_013947.1|WP_013020096.1|5188517_5189255_-|chitinase
MRRRPALLTIAAAAIISALALVFPTATAQADDDSTPDTEAAFVVSEAQFNQMFPNRNPFYTYEGLTTAMNSYPEFANSGGDTVMKQEAAAALANFSHETGGLVHIVEQDQSNYPHYCDTTQPYGCPAGNDAYYGRGPIQLSWNFNYKAAGDNLGIDLLNNPWQVEQNAAVAWQTGLWYWMTQNGPGSMTAHNAMVNGAGFGETIRAINGSLECNGGNPGQVQSRVDKYKAFTAILGVDPGGNLTC
>NC_013947.1|WP_144300849.1|5186491_5188129_-|ATP-binding-cassette-domain-containing-protein
MREHSHANTTVSQLSFAEVTKSYGEHVVLDQISFTVRTGEKVGVIGENGSGKSTLMRLIAGVEPPDNGDVTVVAGGGIGHLGQTLELPGDNTVADAIDAALADLRELERLMREAEATLDSAGEAELAAYGDLLSAYEARGGYEADARVDAAMHGLGLAHLTRDRLLGTLSGGEQSRLGLACVLAADPELLLLDEPTNHLDTQAVSWLEDRLRQHRGTVVAVTHDRAFLAAITSTILEVDRDLRSVTRYGDGWKGYLTAKAAAKRRWEQDYQDWCDEIERLTEATQTNASLFAAKIKSVKHDRSASHRRSHEAGLSSKVRESRERLRRLRENPVPEPPKPLRFAARFDGGKGEGLAAELIDVRVGDRLHVDKFRLAPGQRMLLTGPNGAGKTTLLRVLARDLKPDSGTVRRPKRLGYLRQELADNPPRRTVLAAFAEGLPGEPDEHVQTLESLGLLSRSDFTKLVPDLSIGQRRRLELARLVTRPADLLVLDEPSNHLSLALVGELEEALREFKGSLLVVSHDRSFAEGFDGDRVELRDGRLVEAM
>NC_013947.1|WP_013020094.1|5184924_5186406_+|alpha/beta-hydrolase
MRRRWYPAMAAVAVVAAGLTWTGLPSAQAQSSDLDWSDCGGRAQCATLTVPVDWNDPDGPTTRVNLAKLPARDPGAADRPLLVNLGAGNTTAALEADQVPPGVAALNERFDVIGFDPRGLGKDANDTLIHCAESQAPYPGLVLAEDAKDWRAHAKRNAKYERSCREAAGAEYAGLTSTQIAHDMDALRTALDQPKLKYFGNSYGTSYGQAYAELFGDKVERMYLDGVADHTQPKLSDWLTNYARTTEQQLTEFADWCSTRDGCALNDEDAAKVWDDLVKRAETEPIPAPGAGDGETVNVRELLAGGHFGLTPTSWPRLAVAMDSARDGDASDFLTELVWPPDTGKGGHVQGALLCNDFMPEQLSYRQTLKLEKRLRDIAPRIGWVTARAELSRCVGMDAKPANPPHRLDVDDLPPVLVGIGDLDANTPHHGAENVASQLPDASVLRHGDGHAAFVLGNKCLANHVTAYFADGTLPDEGTRCPGELVDQIPDKP
>NC_013947.1|WP_052305318.1|5183754_5184801_+|acyl-CoA-desaturase
MLLSANALSPVGEKTSRYPQLAKQIRDAGLLRRRPWYYAWRISATVAAYAAAWAVFVLVGDSWWQLFTAAAMAVTFMQFGFLGHDAGHQQIFGSRRGNSIVGYLLGNLGLGLSFGWWSDKHTRHHANPNVEGRDPDLNVDPVAFTDAQAARSRGIGKQIVRFQAALFIPLLFLEAFHMHFNSLRRIVNRNRPIRARGLEAVLFTVHVVAYLGIVFTVLSPGTAVVFIFVHQGLLGVYMGASFAPNHKGMPVLTDGEQADFLLRQVLTARNIDGGRFVDAALGGLNYQIEHHLFPHMPRPNLRQAQPVVRQFCAEHDIAYCQTSMFGSWGRVLGHLHDMGRDIRNPGSP
>NC_013947.1|WP_144300848.1|5182885_5183635_+|ANTAR-domain-containing-protein
MREHRLAETFVELADTLVANFDVVDFTHVLANRCVELLDAAAVGLMLIDQHSQLRVIASSDEQSRVLELFELEADHGPCLECFRTGHQVADPDLRDADTRWPRFAAKAVEAGYLAVQAIPMRLRGETIGVLNLFRQQPGALDETLLRTGQALADVATIGLLHERAVRHHQILAEQLQGALNSRVVIEQAKGLLSERFNVDMPTAFVVMRKFARRTNRKLSDVAQDVVSGRLETRELVVPMDKATEPEPT
>NC_013947.1|WP_013020103.1|5195038_5195425_-|hypothetical-protein
MTDEPYIDFDGDGSEDEYSTEELDGGGYAHTSEDGEVAYDYDGDGLIDELHTDEDGNGSLDTVHIDETGDGYMDSEESLEEEPADTEEPPADTTAGSSSGMPLGYLGGEGTASGTEEETGATEKPAGS
>NC_013947.1|WP_013020104.1|5195534_5198804_-|S41-family-peptidase
MTTGYPRFPAIHNDTIVFVAEDDLWSVTTAGGTARRLTAGVAAASFPRISPDGSLIAYTGAEEGPPDVHVVPTEGGETRRLTYEGGRISRVAGWDPTGEFVIYATSAHSPELLDVRLRRVSADGGVPAELTWGRATAIAQGSNGVVVLGREYWKDHAHWKRYRGGTAGQLWIDASGDGEFRKLVSLDGNLSCPHIIGDRVYFLSDHEGHGNVYSTDFDGANLRRHTDHEDFYARGLSGDGARLVYHCGGRLYLLDPAEEHPSVVDVHIPVTRTQRARRFVDAAEYLDSVDLSADASHLAVTTRGKAFTFADWEGPVTQHGEVDGVRYRLLTWLHDRERLIAAVADNGPREVLVGITADASKPPCRLDHLDTGRAGELVASPTEGKVVIANHRNELVLVDVDGEEATATVIDSSRHGEISDVVFSADGTWLAYACPESSGTDNEDENVARSTIKLLELSTGRKAVAAKRILNDFGPSFDPDGKYLYFVGQREFNPVYDSLHFDLNFPMGSRPYAVALRADVSPPFVPQPKPMHDTGEESTKDSGDDESKTDSDDTTDESLVIDLDGIENRIVPLPVSDAKYTQVLGVSGKVLVLSHPVAGRIRPHQVDDEPDGVLDSVDLETGKVERFADAVSWVMSTPDGKTVLYMSGDKMRVVKATEKAPDGADRNRESGWIDLDRLKVSVRPELEWPQMFREAWRLLSENFWVEDMSGVDWNAIYERYAPLVAQLSTRGELSDLIWEMNGELGTSHVYEALGDYRPGPHYGQGYLGADFTVDTDGAHTIAKIYTGDPWKPDATSSLLRPGVDARVGDTVVAVNGQPVGPTTSVAQLLVNQADQEVRLSLRRGEADPHVVVVRALSNEQPLRYRDWVEANRRAVYDASGGRLGYIHIPDMMTEGFAEFHRGFLNEYDRDGLVVDVRFNGGGHVSPLLLEKLARRRIGYNFSRWSRPAPYPRESPCGAMVALINESAGSDGDIFSHGFRSYNLGPLVGTRTWGGVVGYFPWRPNLADNTFLSQPEIAFHFDDAKWGVENYGVAPDIEVEYAPQDYAAGRDPQLEAGIAAALKELEKKPAHRPDPADRPKLAAPKLPPRP
>NC_013947.1|WP_083787212.1|5198876_5199866_+|lipoyl-synthase
MTPTRYSRDPVSARRLAIVTTVQPEGRRMLRIEARNAQTPIERKPSWIKVKAKMGPEYRDLRGLVDREGLHTVCQEAGCPNIYECWEDREATFLIGGDQCTRRCDFCQIDTGKPQPLDRDEPRRVADSVSTMGLKYATITGVARDDLDDGGAWLYAETVRQIHAAVPGCGVELLIPDFNAEPEQLAEVFSARPEVLAHNIETVPRIFKRIRPGFRYERSLEVITKAREDGLVTKSNLILGMGETREEVSQALRDLHEAGCELITITQYLRPTPRHHPVDRWVKPEEFVELSAEAEAMGYAGVMSGPLVRSSYRAGRLYRQALDARTPVA
>NC_013947.1|WP_144300850.1|5199930_5200590_+|DUF4191-family-protein
MKQIGMAFSFTTKRDKAFLPLAIVAVLIPLAAGAVLVFVTETLPWPFAIVAVFVALIFMMIVLNWRTSKAVMGQAVGQQGAAYAIVDQMRGWHITPAVAVSPNQDLVHRAVSKSGIVLLAEGGSARMKSLINQEKKKLNRVVGTTPIYDFVVGEDEDQLSVRKLRKTLMKLPRNITAKQANDLNRRLNALKQSKPPMPKGPVPQNMKPPKGARRAMRGK
>NC_013947.1|WP_013020107.1|5200672_5201098_-|RDD-family-protein
MSRPKATSPTEPQQDEVPELATFGQRFAALIVDWILCVLLGNGLVAVNVLPELEYPVWPSVLMALYYAVFVGFFTQTVGMRLAKIHCVNAAEGTPLGLPRALLRGVLVVLVIPILTAFSDPHRRGLHDKLSGSAVIRPKAS
>NC_013947.1|WP_041625143.1|5201273_5202698_+|type-I-glutamate--ammonia-ligase
MFTSPDQLLAYIKDNKVKFIDVRFCDLPGVMQHFNVPAESFTEETFAEGLAFDGSSIRGFQAIHESDMLLLPDVTTAFLDPFRAEKTVALNFFIHDPFTREAYSRDPRNIAKKAEQYLASSGIADTAYFGAEAEFYIFDDVRFDTAPQHGFFHIDSVEGAWNSGKVEEGGNRGYKPKHKGGYFPVPPVDHFADLRDGIVRTLVDTGIEVERAHHEVGTAGQTEINYKFSTLLNAGDQLQLFKYIVKNQVWAAGKTATFMPKPMYGDNGSGMHTHQSLFRDGTPLFYDETGYAGLSDTARWYIGGLLKHAPSLLAFTNPTVNSYRRLVPGYEAPVNLVYSQRNRSACTRIPVTGNNPKAKRVEFRVPDPSSNPYLAFSSMLMAGLDGIKNKIEPPDPVDKDLYELAPEEFGDVAQVPGSLPEVLDKLESDHGFLLEGGVFTPDLIETWIDYKRTAEVDEIRLRPTPQEFLLYFDV
>NC_013947.1|WP_013020109.1|5202747_5203140_-|VOC-family-protein
MSVQLNHTIVAAKDRSESAEFLADILGLEVGAPMGPFLPVQLHNGVTLDFAQQPPDKEFAPQHYAFLVSEAEFDAAFDKIKRYRLTFWADPRQHLEGEINHHDGGRGVYFLDPSGHYLELITVPYGGWPA
>NC_013947.1|WP_013020110.1|5203338_5203623_+|hypothetical-protein
MRRGAVYVLVTGLVAVAAGVLVFITVASASSPEDLGPKVTVPSEPTAPDGGSGSDDGATKVPGPSPSTAGGEEDDDNDDAGEDGSDDADDDADD
>NC_013947.1|WP_144300626.1|5203615_5205358_+|HAMP-domain-containing-protein
MTDRGGAGFSARARILAWMLLLVTGALFVSVFATYEVLLSRLDVRLEDELGHEVDKFRGFTKGGLNPATGEAYTGVEQVLEVYLYRSLPEEHETYVAVVDGVPYKRSAKEPPARIDQNRELIKRITDVDAPATGWIETSAGEARYAAIPVTVDGRDEVGHLVVAEFRDVEAADINEAMVVLILVGLAAIGLAGIGGWLAAGRILAPVRLVRNTAERISETDLSERIPVRGRDDVAALTQTFNTMLDRLEESFAAQREFVDDAGHELRTPITVVRGHLELLGQGIDDADERAETLRLVMDELDRMRRIVDDLLVLAKSGTPDFLRPADVDLAELTVEVVAKVRTLGDRRFVIDEMAETVIRSDEQRLTQALMQLVANAVRHTGPGDEIGVGSSVTEQRVRLWVRDSGPGVAAADRERIFERFVTGPARDREGNGSTGSGAGLGLAIVRAIAEAHGGRVTVTDAGDGAASDRRRLAEAMASAGGAGAARLSRDVSAGAGGTAKTPVTSAGRGTDEFEDAEPGGAAASGEPATAAGGAEATGPGMAGSGGIAASAARVGGREPAARAASVAGGAVFTIEVPRR
>NC_013947.1|WP_013020112.1|5205354_5206020_+|response-regulator-transcription-factor
MSRILIIEDSERITAFLTKGLAAAGFTPSVAHTGAEGLGRALTGEVDLIVLDIGLPDMDGFDLLRALRAAGRDTPVIILTARDSATDRVTGLSDGADDYMPKPFSVDELLARIRLRLRPVSGGGSDQAVLRVGDLELDLRTRAVRAGGRQVELTARELSLLDTLMRNAGQVLSREQLLSRVWGFDFDPGSNVVDVYVRYLRRKIGADRIETVRGLGYRLTQ

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Crispr_ID: NC_013947_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_15

5200558-5200651

Orphan

Consensus_repeat	Method
AAGGGCGCGCGTCGCGCGATGCGCGGCAAGTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_15

>merge|NC_013947|15|5200558-5200651|CRISPRCasFinder
AAGGGCGCGCGTCGCGCGATGCGCGGCAAGTAACGGCCGTAACGCATTCAGGCCGTACGCGTAAGGGCGCGCGTCGCGCGATGCGCGGAAAGTA

>NC_013947|15|14|5200558-5200651|CRISPRCasFinder
AAGGGCGCGCGTCGCGCGATGCGCGGCAAGTA	ACGGCCGTAACGCATTCAGGCCGTACGCGT
AAGGGCGCGCGTCGCGCGATGCGCGGAAAGTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013020115.1\|5208832_5210764_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020096.1\|5188517_5189255_-\|chitinase	unknown	unknown	gnl\|CDD\|381595
NC_013947.1\|WP_013020110.1\|5203338_5203623_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368199
NC_013947.1\|WP_013020102.1\|5194401_5194830_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273344
NC_013947.1\|WP_013020107.1\|5200672_5201098_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NC_013947.1\|WP_052305319.1\|5192676_5194008_-\|aspartate--tRNA(Asn)-ligase	unknown	unknown	gnl\|CDD\|235354
NC_013947.1\|WP_013020112.1\|5205354_5206020_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_013947.1\|WP_013020116.1\|5210874_5211054_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020104.1\|5195534_5198804_-\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|227282
NC_013947.1\|WP_083787212.1\|5198876_5199866_+\|lipoyl-synthase	unknown	unknown	gnl\|CDD\|235493
NC_013947.1\|WP_041625139.1\|5190979_5191867_-\|glutamate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270408
NC_013947.1\|WP_041626780.1\|5206077_5206641_+\|DUF4956-domain-containing-protein	unknown	unknown	gnl\|CDD\|379819
NC_013947.1\|WP_013020098.1\|5189903_5190887_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|349754
NC_013947.1\|WP_169313960.1\|5207537_5208872_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NC_013947.1\|WP_083787211.1\|5191865_5192633_+\|lipoyl(octanoyl)-transferase-LipB	unknown	unknown	gnl\|CDD\|184638
NC_013947.1\|WP_013020109.1\|5202747_5203140_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319939
NC_013947.1\|WP_013020097.1\|5189439_5189838_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020103.1\|5195038_5195425_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_041625143.1\|5201273_5202698_+\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|273198
NC_013947.1\|WP_144300626.1\|5203615_5205358_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013020096.1\|5188517_5189255_-\|chitinase	gnl\|CDD\|381595	cd00325, chitinase_GH19, Glycoside hydrolase family 19, chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Glycoside hydrolase family 19 chitinases are found primarily in plants (classes I, III, and IV), but some are found in bacteria. Class I and II chitinases are similar in their catalytic domains. Class I chitinases have an N-terminal cysteine-rich, chitin-binding domain which is separated from the catalytic domain by a proline and glycine-rich hinge region. Class II chitinases lack both the chitin-binding domain and the hinge region. Class IV chitinases are similar to class I chitinases, but they are smaller in size due to certain deletions. Despite lacking any significant sequence homology with lysozymes, structural analysis reveals that family 19 chitinases, together with family 46 chitosanases, are similar to several lysozymes including those from T4-phage and from goose. The structures reveal that the different enzyme groups arose from a common ancestor glycohydrolase antecedent to the prokaryotic/eukaryotic divergence.	2.65047e-84
NC_013947.1\|WP_013020110.1\|5203338_5203623_+\|hypothetical-protein	gnl\|CDD\|368199	pfam04931, DNA_pol_phi, DNA polymerase phi. This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.	0.00307621
NC_013947.1\|WP_013020102.1\|5194401_5194830_-\|hypothetical-protein	gnl\|CDD\|273344	TIGR00927, retinal_rod, K+-dependent Na+/Ca+ exchanger. [Transport and binding proteins, Cations and iron carrying compounds].	3.37824e-05
NC_013947.1\|WP_013020107.1\|5200672_5201098_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	5.81748e-14
NC_013947.1\|WP_052305319.1\|5192676_5194008_-\|aspartate--tRNA(Asn)-ligase	gnl\|CDD\|235354	PRK05159, aspC, aspartyl-tRNA synthetase; Provisional.	0
NC_013947.1\|WP_013020112.1\|5205354_5206020_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.83854e-81
NC_013947.1\|WP_013020104.1\|5195534_5198804_-\|S41-family-peptidase	gnl\|CDD\|227282	COG4946, COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown].	5.71546e-147
NC_013947.1\|WP_083787212.1\|5198876_5199866_+\|lipoyl-synthase	gnl\|CDD\|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	0
NC_013947.1\|WP_041625139.1\|5190979_5191867_-\|glutamate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.282e-102
NC_013947.1\|WP_013020098.1\|5189903_5190887_-\|ATP-binding-protein	gnl\|CDD\|349754	cd02034, CooC1, accessory protein CooC1. The accessory protein CooC1, a nickel-binding ATPase, participates in the incorporation of nickel into the complex active site ([Ni-4Fe-4S]) cluster of Ni,Fe-dependent carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible oxidation of CO to CO2. CODH contains a nickel-iron-sulfur cluster (C-center) and an iron-sulfur cluster (B-center). CO oxidation occurs at the C-center. Three accessory proteins encoded by cooCTJ genes are involved in nickel incorporation into a nickel site. CooC functions as a nickel insertase that mobilizes nickel to apoCODH using energy released from ATP hydrolysis. CooC is a homodimer and has NTPase activities. Mutation at the P-loop abolishs its function.	1.1876e-28
NC_013947.1\|WP_169313960.1\|5207537_5208872_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	1.36398e-69
NC_013947.1\|WP_083787211.1\|5191865_5192633_+\|lipoyl(octanoyl)-transferase-LipB	gnl\|CDD\|184638	PRK14345, PRK14345, lipoyl(octanoyl) transferase LipB.	1.28294e-115
NC_013947.1\|WP_013020109.1\|5202747_5203140_-\|VOC-family-protein	gnl\|CDD\|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	9.26435e-66
NC_013947.1\|WP_144300626.1\|5203615_5205358_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.7275e-54
NC_013947.1\|WP_041626780.1\|5206077_5206641_+\|DUF4956-domain-containing-protein	gnl\|CDD\|379819	pfam16316, DUF4956, Domain of unknown function (DUF4956). This family consists of uncharacterized proteins around 220 residues in length and is mainly found in various Bacteroides species. The function of this protein is unknown.	1.1529e-61
NC_013947.1\|WP_041625143.1\|5201273_5202698_+\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0

>NC_013947.1|WP_083787212.1|5198876_5199866_+|lipoyl-synthase
MTPTRYSRDPVSARRLAIVTTVQPEGRRMLRIEARNAQTPIERKPSWIKVKAKMGPEYRDLRGLVDREGLHTVCQEAGCPNIYECWEDREATFLIGGDQCTRRCDFCQIDTGKPQPLDRDEPRRVADSVSTMGLKYATITGVARDDLDDGGAWLYAETVRQIHAAVPGCGVELLIPDFNAEPEQLAEVFSARPEVLAHNIETVPRIFKRIRPGFRYERSLEVITKAREDGLVTKSNLILGMGETREEVSQALRDLHEAGCELITITQYLRPTPRHHPVDRWVKPEEFVELSAEAEAMGYAGVMSGPLVRSSYRAGRLYRQALDARTPVA
>NC_013947.1|WP_013020104.1|5195534_5198804_-|S41-family-peptidase
MTTGYPRFPAIHNDTIVFVAEDDLWSVTTAGGTARRLTAGVAAASFPRISPDGSLIAYTGAEEGPPDVHVVPTEGGETRRLTYEGGRISRVAGWDPTGEFVIYATSAHSPELLDVRLRRVSADGGVPAELTWGRATAIAQGSNGVVVLGREYWKDHAHWKRYRGGTAGQLWIDASGDGEFRKLVSLDGNLSCPHIIGDRVYFLSDHEGHGNVYSTDFDGANLRRHTDHEDFYARGLSGDGARLVYHCGGRLYLLDPAEEHPSVVDVHIPVTRTQRARRFVDAAEYLDSVDLSADASHLAVTTRGKAFTFADWEGPVTQHGEVDGVRYRLLTWLHDRERLIAAVADNGPREVLVGITADASKPPCRLDHLDTGRAGELVASPTEGKVVIANHRNELVLVDVDGEEATATVIDSSRHGEISDVVFSADGTWLAYACPESSGTDNEDENVARSTIKLLELSTGRKAVAAKRILNDFGPSFDPDGKYLYFVGQREFNPVYDSLHFDLNFPMGSRPYAVALRADVSPPFVPQPKPMHDTGEESTKDSGDDESKTDSDDTTDESLVIDLDGIENRIVPLPVSDAKYTQVLGVSGKVLVLSHPVAGRIRPHQVDDEPDGVLDSVDLETGKVERFADAVSWVMSTPDGKTVLYMSGDKMRVVKATEKAPDGADRNRESGWIDLDRLKVSVRPELEWPQMFREAWRLLSENFWVEDMSGVDWNAIYERYAPLVAQLSTRGELSDLIWEMNGELGTSHVYEALGDYRPGPHYGQGYLGADFTVDTDGAHTIAKIYTGDPWKPDATSSLLRPGVDARVGDTVVAVNGQPVGPTTSVAQLLVNQADQEVRLSLRRGEADPHVVVVRALSNEQPLRYRDWVEANRRAVYDASGGRLGYIHIPDMMTEGFAEFHRGFLNEYDRDGLVVDVRFNGGGHVSPLLLEKLARRRIGYNFSRWSRPAPYPRESPCGAMVALINESAGSDGDIFSHGFRSYNLGPLVGTRTWGGVVGYFPWRPNLADNTFLSQPEIAFHFDDAKWGVENYGVAPDIEVEYAPQDYAAGRDPQLEAGIAAALKELEKKPAHRPDPADRPKLAAPKLPPRP
>NC_013947.1|WP_013020103.1|5195038_5195425_-|hypothetical-protein
MTDEPYIDFDGDGSEDEYSTEELDGGGYAHTSEDGEVAYDYDGDGLIDELHTDEDGNGSLDTVHIDETGDGYMDSEESLEEEPADTEEPPADTTAGSSSGMPLGYLGGEGTASGTEEETGATEKPAGS
>NC_013947.1|WP_013020102.1|5194401_5194830_-|hypothetical-protein
MSDDVFVDFDGDGAGDEYETETLDDGSTAYISEDGEVAVDENGDGIIEELYTDEDGDGNLDTQMSDLDGDGYVDTEASFEGDPLGEEETKGEESSDDKSGEGEKSGEGESGGEKTEDDKSGEGESGGSNSEGKGEGGLDSIF
>NC_013947.1|WP_052305319.1|5192676_5194008_-|aspartate--tRNA(Asn)-ligase
MTAPSPAAPTTPPRVLSAALSEHVGARIRIAGWLHRRRLLKSVAFAIVRDRSGLAQVVVSEEVARARLEELNEETVVEVTGTVVANPAAPGGVELVEPVITVLGEAEAPPFDLYRPSLRATLPTLLDRAPVSLRHPRRKAAFELASAATMGFRETVAAMDFTEIFTPKIVASATESGANVFAIDYFGRPGYLAQSPQFYKQTMVGVFERVFEVGPVFRAEPHDTVRHLAEYTSLDVEFGFIESYRDVAEVLREVVAGMVSAVAERAAAAVALLEPVVPQVPSRFPELHFAEALELISRETGEDLSGVNDLSPAHERWVGEWARREHGSDFAVVVGYPMSKRPFYTAEDPGRPGYSDSFDLLFRGTEMVTGGRRLHRYADYLAAIAAQGGSPEPYAGYLEAFKHGMPPHGGFAIGLERFVAQLTGVANIREVTLFPRDLHRIAP
>NC_013947.1|WP_083787211.1|5191865_5192633_+|lipoyl(octanoyl)-transferase-LipB
MRRTGVPFTARGSRTSTIRVTRDRLHPAKPRGDPSARTRLGGVSDTRARTLKIDRLGTVDYARAWDLQKDLQDKRINDEIDDTVLLLEHPSVYTAGRRTEKWTYPDDGTPVVEVDRGGQITWHGPGQLVGYPIVKLTKPIDVVKYVRRVEDMLMAVCGEFGVATTRIDDRTGVWIPADDRGPERKIASIGVRVRWAVTLHGFALNCDNDMSFFDHIVPCAIMDKDMTSLSRETGRDVTVDEVIPVTEKHMHLILD
>NC_013947.1|WP_041625139.1|5190979_5191867_-|glutamate-ABC-transporter-substrate-binding-protein
MRRAVLAVAVLSVAVATGCQADTVDDTVPPFYNIDQAERSEMPKEVRDILDSGRLTIGSKFDQPLTGLRDKATGRIEGFDAEIGRIITQRIFGKVAEGENLDFIETVPANREKYLEDGTVDLVLATYTITPERKKAVTFAGPYYEAGQAIMTRKGEGIEDIKDLSKKKVCAAEGTTSLDNVEKHNPRANVSKPMRNWSSCRQALLEKEYDAVSTDDVILYGFLSEDPSKLEISKKTFTTEPYGIGLPKGSTELQKFINETLELAFDNGDWQTAFDSTLAVAEVPDPESPPNITEK
>NC_013947.1|WP_013020098.1|5189903_5190887_-|ATP-binding-protein
MKIAFVGKGGSGKTTLASLFARRAVAAGHPVFAIDADINQHLAAALGVDEDTAAKLPKLGDHLAEIKEYLRGDNPRIASAEAMVKTTPPGSGSRLLTIGEDNPVYDACVRNLAGLRLAVTGGFAEDDLGVACYHSKVGAVELMLNHLVDGPGEYVIVDMVAGAEAFASGLFTRFDRTFLVCEPTVRSVGVYKQYAEYAADYDVAISVIGNKIDEPEDVDFLREHVGDALFGWCGRSKFVKAAERGSVGPIADLEPENLALLDRARELVELGGKDWARFSEQARLFHRRNAEAWGNSRMGVDLSEQIDPDFVLGPDSTTDTRGMAKVS
>NC_013947.1|WP_013020097.1|5189439_5189838_-|hypothetical-protein
MSLDVSAELLDKAERGEVSDAEFVDCVRTSLPFAWSMISRVVGDLRDGDPTAEFADNVTPPPDEAARGQLLRALASDAIRGGLERHFGVKLAFQNCHRVAAFRINSVDGDRYRKFISPVGQLRNQSPELRDC
>NC_013947.1|WP_013020096.1|5188517_5189255_-|chitinase
MRRRPALLTIAAAAIISALALVFPTATAQADDDSTPDTEAAFVVSEAQFNQMFPNRNPFYTYEGLTTAMNSYPEFANSGGDTVMKQEAAAALANFSHETGGLVHIVEQDQSNYPHYCDTTQPYGCPAGNDAYYGRGPIQLSWNFNYKAAGDNLGIDLLNNPWQVEQNAAVAWQTGLWYWMTQNGPGSMTAHNAMVNGAGFGETIRAINGSLECNGGNPGQVQSRVDKYKAFTAILGVDPGGNLTC
>NC_013947.1|WP_013020107.1|5200672_5201098_-|RDD-family-protein
MSRPKATSPTEPQQDEVPELATFGQRFAALIVDWILCVLLGNGLVAVNVLPELEYPVWPSVLMALYYAVFVGFFTQTVGMRLAKIHCVNAAEGTPLGLPRALLRGVLVVLVIPILTAFSDPHRRGLHDKLSGSAVIRPKAS
>NC_013947.1|WP_041625143.1|5201273_5202698_+|type-I-glutamate--ammonia-ligase
MFTSPDQLLAYIKDNKVKFIDVRFCDLPGVMQHFNVPAESFTEETFAEGLAFDGSSIRGFQAIHESDMLLLPDVTTAFLDPFRAEKTVALNFFIHDPFTREAYSRDPRNIAKKAEQYLASSGIADTAYFGAEAEFYIFDDVRFDTAPQHGFFHIDSVEGAWNSGKVEEGGNRGYKPKHKGGYFPVPPVDHFADLRDGIVRTLVDTGIEVERAHHEVGTAGQTEINYKFSTLLNAGDQLQLFKYIVKNQVWAAGKTATFMPKPMYGDNGSGMHTHQSLFRDGTPLFYDETGYAGLSDTARWYIGGLLKHAPSLLAFTNPTVNSYRRLVPGYEAPVNLVYSQRNRSACTRIPVTGNNPKAKRVEFRVPDPSSNPYLAFSSMLMAGLDGIKNKIEPPDPVDKDLYELAPEEFGDVAQVPGSLPEVLDKLESDHGFLLEGGVFTPDLIETWIDYKRTAEVDEIRLRPTPQEFLLYFDV
>NC_013947.1|WP_013020109.1|5202747_5203140_-|VOC-family-protein
MSVQLNHTIVAAKDRSESAEFLADILGLEVGAPMGPFLPVQLHNGVTLDFAQQPPDKEFAPQHYAFLVSEAEFDAAFDKIKRYRLTFWADPRQHLEGEINHHDGGRGVYFLDPSGHYLELITVPYGGWPA
>NC_013947.1|WP_013020110.1|5203338_5203623_+|hypothetical-protein
MRRGAVYVLVTGLVAVAAGVLVFITVASASSPEDLGPKVTVPSEPTAPDGGSGSDDGATKVPGPSPSTAGGEEDDDNDDAGEDGSDDADDDADD
>NC_013947.1|WP_144300626.1|5203615_5205358_+|HAMP-domain-containing-protein
MTDRGGAGFSARARILAWMLLLVTGALFVSVFATYEVLLSRLDVRLEDELGHEVDKFRGFTKGGLNPATGEAYTGVEQVLEVYLYRSLPEEHETYVAVVDGVPYKRSAKEPPARIDQNRELIKRITDVDAPATGWIETSAGEARYAAIPVTVDGRDEVGHLVVAEFRDVEAADINEAMVVLILVGLAAIGLAGIGGWLAAGRILAPVRLVRNTAERISETDLSERIPVRGRDDVAALTQTFNTMLDRLEESFAAQREFVDDAGHELRTPITVVRGHLELLGQGIDDADERAETLRLVMDELDRMRRIVDDLLVLAKSGTPDFLRPADVDLAELTVEVVAKVRTLGDRRFVIDEMAETVIRSDEQRLTQALMQLVANAVRHTGPGDEIGVGSSVTEQRVRLWVRDSGPGVAAADRERIFERFVTGPARDREGNGSTGSGAGLGLAIVRAIAEAHGGRVTVTDAGDGAASDRRRLAEAMASAGGAGAARLSRDVSAGAGGTAKTPVTSAGRGTDEFEDAEPGGAAASGEPATAAGGAEATGPGMAGSGGIAASAARVGGREPAARAASVAGGAVFTIEVPRR
>NC_013947.1|WP_013020112.1|5205354_5206020_+|response-regulator-transcription-factor
MSRILIIEDSERITAFLTKGLAAAGFTPSVAHTGAEGLGRALTGEVDLIVLDIGLPDMDGFDLLRALRAAGRDTPVIILTARDSATDRVTGLSDGADDYMPKPFSVDELLARIRLRLRPVSGGGSDQAVLRVGDLELDLRTRAVRAGGRQVELTARELSLLDTLMRNAGQVLSREQLLSRVWGFDFDPGSNVVDVYVRYLRRKIGADRIETVRGLGYRLTQ
>NC_013947.1|WP_041626780.1|5206077_5206641_+|DUF4956-domain-containing-protein
MTQILIHLGLDIVAAAALAITYGIRHHRRDLVLAYAALNIGVFAVVTLLSDADSAAALGFGLFGILSIIRLRSDAITQEEVAYYFVALALGLVNGLAIPDFRVTLLLNVVLLGVMFVADHSLLLRRSRRQQVVLDVLHSDQTALVADLERRLGGRVLHHIVTDVDFVRETTTVDVRFRLGARDRVRV
>NC_013947.1|WP_169313960.1|5207537_5208872_+|MFS-transporter
MTATATTTPGITTGPAPTRGWFAVVSVMTGLFAIVTTEILPIGLLVPIRDGFGVSDGVAGLTMTLPGLLAAVAAPLVTVATARLDRRVMLCVLMAVLAVANLLAALAPAFWVMLVSRILVGVVIGGFWSIGAGLAPRLVRAKAVSMATAVVFAAVPLGSVLGVPAGTFLGSLAGWRAAFAVMTAVSVAVLVALALSLPGLPPLRVTGAAVLRELLRRKAVRYGLLVTAVVVVAHFATYTYVTPLLVEVNAVDVGLISTLLLVYGVAGVAGNFVAGAVMARGHRAVFAVAALVLAAATLLLPLAGNGIVPVAGLLVLWGLAYGAVPACSQTWFARAAPDAPEAATVVFTASFQAALSAGALVGGVVVDATSTVTVMLAGSGLAVVAAALIAATRGSRRIRVLCLVRQPFDTRRRLGGRDGQAVHQQTNSKEQACESAIWSRRRPW
>NC_013947.1|WP_013020115.1|5208832_5210764_+|hypothetical-protein
MRKRYLVAAATVVMLSGVTAWVYADPAAPDPNPTADAGGDATVVLPTGDTVTLLPGGGVAVRPGDGRADAGFFRAGGTTDFIMVPMDQAADIASGERDPRRYNVSALLREGQHDAAKAPKSRLDDREYDGYAPASPGTRDSAANQKVTITLKDRHGKAPEYTDVLWSALGGEAFEKLTFDENGVSTTELPAGTYDLQLIFGTQSDQSGDVIEGISTFTVADEPVDLTIDGAKAQPVTAEVDAKDAEPQTRKVDMYAKGSNVGVYTLTGGKHDHYVLPTKSGASEGVSFNFGTSLTSPKGADEPYSYQLAFPGADGVPEDLSFEVPDEQLAEVATDFQSLGTESAAGYCFAGIPPDIGIGFQNCIETSFPVPGDQTVRYTPEPVKWHGYTRVGASESTMVTFGTTVEGTTYPAGPGEQSFNTAPLTIGLMENGAMRMSQGLGVTPAMMNHFDSDSLGYGRGYSGSITLSEGDTQLGHYEGVLDNSGGGFDLEPDASGRFTLTVDGKREADDVTPLNTHSTATWEFDCPKAPGDDEAETVAASYVVLAADGVTDGYAQAGEKQKVTMEYRPQNADVDTKLTDLKFEVSYDDGDSWDEVKIERDGDSATAELDHPSGAKFVSVRFTATDDTGSELSQQTIRSYGLK
>NC_013947.1|WP_013020116.1|5210874_5211054_+|hypothetical-protein
MDTLLSSRALGYLSILLFMVAAFFALIEFFVTALVVLIASAIIVTGLWQLRLALARRHS

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Crispr_ID: NC_013947_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_16

5558701-5558790

Orphan

Consensus_repeat	Method
GGCGCGAGTCTCGAGGCACTGGCTGCT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_013947_16

>merge|NC_013947|16|5558701-5558790|CRISPRCasFinder
GGCGCGAGTCTCGAGGCACTGGCTGCTACTCCCTTGACCGCTACGGGTTGACTTGCGCCAGTTGGCGCGAGTCTCGACGCACTGGCTGCT

>NC_013947|16|15|5558701-5558790|CRISPRCasFinder
GGCGCGAGTCTCGAGGCACTGGCTGCT	ACTCCCTTGACCGCTACGGGTTGACTTGCGCCAGTT
GGCGCGAGTCTCGACGCACTGGCTGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013020445.1\|5562959_5564183_+\|DUF4243-domain-containing-protein	unknown	unknown	gnl\|CDD\|372882
NC_013947.1\|WP_013020439.1\|5559792_5560029_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020440.1\|5559997_5560402_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_013947.1\|WP_013020435.1\|5557125_5557599_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NC_013947.1\|WP_144300639.1\|5561694_5562372_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341042
NC_013947.1\|WP_013020436.1\|5557532_5558414_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_013947.1\|WP_013020427.1\|5549240_5549759_+\|DUF4395-domain-containing-protein	unknown	unknown	gnl\|CDD\|379566
NC_013947.1\|WP_041626895.1\|5562399_5562675_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|223713
NC_013947.1\|WP_013020433.1\|5555139_5555883_+\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|181038
NC_013947.1\|WP_013020431.1\|5552507_5553206_+\|succinate-dehydrogenase-cytochrome-b-subunit	unknown	unknown	gnl\|CDD\|239578
NC_013947.1\|WP_013020447.1\|5565009_5566755_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013947.1\|WP_013020432.1\|5553202_5555143_+\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236054
NC_013947.1\|WP_013020428.1\|5549765_5550812_-\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|226614
NC_013947.1\|WP_169313921.1\|5556022_5557123_+\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|176896
NC_013947.1\|WP_013020438.1\|5558831_5559650_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NC_013947.1\|WP_013020430.1\|5551473_5552424_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176102
NC_013947.1\|WP_013020441.1\|5560431_5561355_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373062
NC_013947.1\|WP_144300638.1\|5561485_5561698_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_144300860.1\|5564775_5565006_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|117022
NC_013947.1\|WP_013020429.1\|5550936_5551419_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013020445.1\|5562959_5564183_+\|DUF4243-domain-containing-protein	gnl\|CDD\|372882	pfam14027, DUF4243, Protein of unknown function (DUF4243). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 348 and 477 amino acids in length.	5.06649e-11
NC_013947.1\|WP_013020447.1\|5565009_5566755_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.35016e-114
NC_013947.1\|WP_013020428.1\|5549765_5550812_-\|FUSC-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	5.24679e-18
NC_013947.1\|WP_013020435.1\|5557125_5557599_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	6.2765e-26
NC_013947.1\|WP_144300639.1\|5561694_5562372_-\|hypothetical-protein	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0.00264716
NC_013947.1\|WP_013020436.1\|5557532_5558414_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	3.70757e-20
NC_013947.1\|WP_013020427.1\|5549240_5549759_+\|DUF4395-domain-containing-protein	gnl\|CDD\|379566	pfam14340, DUF4395, Domain of unknown function (DUF4395). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 142 and 168 amino acids in length. There are two completely conserved C residues that may be functionally important.	1.97755e-36
NC_013947.1\|WP_041626895.1\|5562399_5562675_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	5.26104e-20
NC_013947.1\|WP_013020433.1\|5555139_5555883_+\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	gnl\|CDD\|181038	PRK07570, PRK07570, succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated.	0
NC_013947.1\|WP_013020431.1\|5552507_5553206_+\|succinate-dehydrogenase-cytochrome-b-subunit	gnl\|CDD\|239578	cd03498, SQR_TypeB_2_TM, Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. C. glutamicum SQR reduces low potential quinones such as menaquinone. SQR is also called succinate dehydrogenase (Sdh) or Complex II and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type B as they contain one transmembrane subunit and two heme groups. The heme and quinone binding sites reside in the transmembrane subunit. The transmembrane subunit of members of this subfamily is also called Sdh cytochrome b558 subunit based on the Bacillus subtilis protein. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit containing the electron acceptor (quinone). The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes. Proteins in this subfamily from G. metallireducens and G. sulfurreducens are bifunctional enzymes with SQR and QFR activities.	1.89878e-52
NC_013947.1\|WP_013020432.1\|5553202_5555143_+\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236054	PRK07573, sdhA, fumarate reductase/succinate dehydrogenase flavoprotein subunit.	0
NC_013947.1\|WP_013020430.1\|5551473_5552424_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176102	cd05466, PBP2_LTTR_substrate, The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily. This model and hierarchy represent the the substrate-binding domain of the LysR-type transcriptional regulators that form the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, oxidative stress responses, nodule formation of nitrogen-fixing bacteria, synthesis of virulence factors, toxin production, attachment and secretion, to name a few. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	6.82005e-50
NC_013947.1\|WP_169313921.1\|5556022_5557123_+\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|176896	cd08887, RHO_alpha_C_3, C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases. C-terminal catalytic domain of the oxygenase alpha subunit of a functionally uncharacterized subgroup of the Rieske-type non-heme iron aromatic ring-hydroxylating oxygenase (RHO) family. RHOs, also known as aromatic ring hydroxylating dioxygenases, utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. This group contains a putative Parvibaculum lavamentivorans (T) DS-1 oxygenase; this organism catabolizes commercial linear alkylbenzenesulfonate surfactant (LAS) and other surfactants, by a pathway involving an undefined 'omega-oxygenation' and beta-oxidation of the LAS side chain. The nature of the LAS-oxygenase is unknown but is likely a multicomponent system. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.	2.63005e-46
NC_013947.1\|WP_013020438.1\|5558831_5559650_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	3.43498e-08
NC_013947.1\|WP_013020441.1\|5560431_5561355_+\|hypothetical-protein	gnl\|CDD\|373062	pfam14428, SCP1201-deam, SCP1.201-like deaminase. A member of the nucleic acid/nucleotide deaminase superfamily prototyped by Streptomyces SCP1.201. Members of this family are predicted to function as toxins in bacterial polymorphic toxin systems.	4.26482e-12
NC_013947.1\|WP_144300860.1\|5564775_5565006_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|117022	pfam08445, FR47, FR47-like protein. The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.	5.14165e-06
NC_013947.1\|WP_013020440.1\|5559997_5560402_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	7.63478e-20

>NC_013947.1|WP_013020436.1|5557532_5558414_-|alpha/beta-fold-hydrolase
MTRKTISTSIAIVGCVLAGVGLVGCDGSGLDEAGEEFKAELFTGTDTFTIGDHQVNVSCSGSPTSDGPIVLLLHGGGDDLTKLADFQKQISKNSRVCSYDRLGAGKSDKPDGEQDYASVGKTLTGVIDTFANGDPVVLVGHSMGGLIAARYAPDNKDKVAGMVLLDATSPTAVADLKQRIPEDATGEAAELRAQTLAIYGGENPEKLVFTDGKVKSAGDIPVRVIQHGKQYLAAVPEYGPGLEDDWTAGQKDWLNVSSDSELDTAKDSGHYIYVDEPDAAVEAVKDVASRAAD
>NC_013947.1|WP_013020435.1|5557125_5557599_+|PaaI-family-thioesterase
MESDELTAFAHSVFNAQPFSRFIGAELVAVSRGTAEIRVKNRPDLQQQHGYLHGGVISYLADNCLTFAGGLALGGDALTSEYKINYASPAKGDVIIARAESLVTTKRQAVCQCSIYSQKDGEEQLVAVAQGTIVKIQSAAREATSLTASTAASGSST
>NC_013947.1|WP_169313921.1|5556022_5557123_+|Rieske-2Fe-2S-domain-containing-protein
MFDEVKTIPVSKYTDTALLDQELASAFTRYPLIASHTAALREPGSYVASDWDQFPYVVVRGEDGKVRGFYNQCRHRGARLLSERSGAIKNFICPFHGWVYGLNGELKGITRSQDFPCVDKSDYGLVELPVTESGGFVWISRTPDAISDIPAFMGRFHDDLESFEVANLVRYKKTKVVKNANWKLLIKTYLEGYHVPYLHRDTLATAFKRGQLAYDKDGPHIRMMAGRTNLTDITAKPEAEWRILDHVSIYYTLFPNTFFILHPDYVSVNTFWPQAPDRTIWTHEMLYRAEDFNGSSGQSALEKRFRFTNDTVFDQEDFAIAEEVQRNLLHGGSDHHVLGLSEGLLAMFQDNIDERLAIHAAQGTER
>NC_013947.1|WP_013020433.1|5555139_5555883_+|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit
MRITLRIWRQSGPKVAGAMTTYKVDDVSPDMSFLEVLDVLNEDLTLRGEEPVAFDHDCREGICGACGVVINGDPHGPSRTTTCQLHMRQFDDGDVIDVEPWRANAFPVVKDLVVDRSGFDRIIGAGGYISAPTGSAPDAHATPVPKPDADLAFDNAECIGCGACVAACPNGSAMLFTAAKVTHLNTLPQGQPERAQRVLNMVNVMDEEDFGGCTLAGECATACPKGIPFESIGNLNREFLKASLKRR
>NC_013947.1|WP_013020432.1|5553202_5555143_+|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit
MTSFTDYTLGEDIADTKAPDGPITERWSTRRFEAKLVNPANRRKQTVIVVGTGLAGGAAGATLAEQGYRVVQFCYQDSPRRAHSIAAQGGINAAKNYRNDGDSIHRLFYDTVKGGDFRARESNVHRLAEVSVEIIDQCVAQGVPFAREYGGLLDTRSFGGVQVSRTFYARGQTGQQLLLGAYQALTRQISAGSVEIHPRTEMLDLIVVDGRARGVVVRDLVTGQISTHLADAVVLATGGYGNVYFLSTNAMNSNATAIWRAHRRGAYFGNPSFTQIHPTCIPRSGDHQSKLTLMSESLRNDGRIWVPKNKGDNRAPGQIPEADRDYYLERQYPSFGNLVPRDIASRAAKNVCDEGRGVGPGGQGVYLDFAEAIERMGAAAVAEKYGNLFEMYERITGENPYKVPMRIYPAIHYTMGGLWVDYDLQTTIPGLFAIGEANFSDHGANRLGASALMQGLGDGYFVLPSTINDFLARHKPEPVAEDHPAVAEAVGGVHTRLTRLLENKGDRTPDSFHRELGEIMWEYCGMSRSDSGLRKALDLIPQLREDFWKRVRVPGNGAELNQSLERANRISDYFELAELMCLDALHRTESCGGHFREESQTADGEAARDDENFSYAAAWEYTGSAPTLHKEQLEFEYVKPTQRSYT
>NC_013947.1|WP_013020431.1|5552507_5553206_+|succinate-dehydrogenase-cytochrome-b-subunit
MALDTRSKRPPVAVTLWKATIGKKIIMALTGLIMIGYLVLHMAGNLKIFSGAKKFNDYSHWLRTFGEPVLPYEGFLWILRVVLLGSVIAHIAAAVALTHRSHQPHRASKKKVLGRNYVTFTMRSGGVILALFVVWHVLDLTTLTVNTRAQAGHPYENLVASFSTWYGNVIYLVAVTAVGFHLWFGTWHAAQTLGVSDAARMRLIRQVAAILATVIAVGFALAPISVMAGVVQ
>NC_013947.1|WP_013020430.1|5551473_5552424_-|LysR-family-transcriptional-regulator
MQLPQLKSFVTVCDTRHFTRAAELLHVAQPSLSQQIKALEHELGTPLFRRARGNITPTDAGAALLPVARRILADTELAYREVADTVDLRRGRVRLGAPPSLCASLVPDIFRVFHDRYPGVELTVDEGGSQDLVRTLTDGELDLALIITHQTGRPAALRVAELLHENLVVASAPQLPPPGKRARITVADLRDQPLVMFRRGYDLRESTITACREAGFEPTFTVEGGEMDAVLGFVRAGLGLAVVPSMVAERSGLRITRFTRSGPERTIAIAHRRDVQPPRAARELHRMLLEHLRSADANGELPPETTLLAEAFAPAE
>NC_013947.1|WP_013020429.1|5550936_5551419_-|hypothetical-protein
MFTGIAYGLWIAAVAATAVILLPATSAAVAIIDCGNGQVRNLDMLTTVGRSGGGAGEPAERAIALSIENRTGTDLTHVEARQALDGALAGSEIVRRPETSHGSVEYDSRGLMWQGDLSSGQRVGVSYAVTVPDKPGGGFHQLRPGSRFQATLSSTAAECA
>NC_013947.1|WP_013020428.1|5549765_5550812_-|FUSC-family-protein
MTRETLTQIAKMTLAAVAAWAIAEQIHPPQSFIAPYAAVFVISETVYRSLVQIGRQLVVVVLGIVLAFGVAATIQYSGAALAVAVAVGMLIGQWRRLGDDGIWVGTIALLMLTYGTADDPAYLYHRIVESLVGVSVGAVINILVFPPVQLRQAHRVVGQVSDMTIALLTAIGDGLRDGWDHETARSWQHRSQNLQRDARGAEESASRGYESTRFNLRRLTRSPRAATPHSYVAAVSVLSDVNTELRRIADALVTATDPHQPDGCPSGDFNGAFAELLDDLATALERYRHPLGPHDEQAEAGVRHGVRRAAQLRRQIIGDGGDHLGVQGMLVLAANRAFHRLRDENQDG
>NC_013947.1|WP_013020427.1|5549240_5549759_+|DUF4395-domain-containing-protein
MNASRSDTVVGRLFAFPNPVNEISARLVAGGVVLMCVAAIAFDQPWLTAVIAYGFVARVLTGPTLSPLGQLVTRFITPRLPVEPVWVAGPPKRFAQGIGVVFSVTAAVLALGLGLHTAAWIVLGALAVAATLESVFAFCLGCKMFAVLMKTGLIPEQVCLECSDLSLRYGTR
>NC_013947.1|WP_013020438.1|5558831_5559650_-|helix-turn-helix-domain-containing-protein
MTDNPLLTRKQLGKMLRELRLSSGKTVEDIEYFGKLWKKSKLYAIENGHQPNPSWPEVEAVAKFLGASNELTRELVRMAKACLNSGWYVPFDISQKFQTYLDLESAANRLHFVEIEMVNGLFQTENYTRALQRALGVPEEKIQNYVDFRMQRAQRFWNRDPFPEVTLLMSEGTLRRVVGGAEVMAEQVDHLRELARRDLVDIVVIPFAAGLNAAMQNAFTLLEFNDDVYPEVAYVESRSECQYHERKPVVALYKWILQEALSVALPIGEIEL
>NC_013947.1|WP_013020439.1|5559792_5560029_+|hypothetical-protein
MTDSSILARDASYTMECHSKVDSEGYCVGCRTYHGQLDKPGPEGCYFYRLAFEVYRKHAASLSHQGAHHVHTLHTRPA
>NC_013947.1|WP_013020440.1|5559997_5560402_+|response-regulator-transcription-factor
MSTLFTPDLRNPVVAWEVIARSAVHIVREARASRRLEPLSIDGRMLFKAVAALGIDLEPPKPTALRTSIQRGLSARESQVLLAIASGKSNAEIGRELFITEDTVKTHARRMYRKLGARDRAHAVAEAFRVGILT
>NC_013947.1|WP_013020441.1|5560431_5561355_+|hypothetical-protein
MASIEELIAAVRSALSTVAEGRTLTTQGCSALIEGTAALTGISRGSTNYQLRTALEALTAAIQAAERAESVEATVLEAIDAYVTEISKGSRPFDLPTLLAKLKNQGVVGLEGRTLEQVPDFDPTRTNPACFQGLAPRQDGGPTRGNLFYSDGRRWNTEPLESSGGASAFDLDKVKLEYRDVTPAQGHLEGNVAAWMADNQERETEMAPLPTPGTTEFSKELVTLTETAYNYFAHPVTVDPRVNRTLIAVYNNSEEQEEDLLALLASVGLHPPAVPDGHVVAGLVVTRFGDDLNNPVLAWDVYGPDDE
>NC_013947.1|WP_144300638.1|5561485_5561698_+|hypothetical-protein
MTVDPRLNRRLIDMDAEPKDPDEFKTFIASLGLVPPPHSRGNVHVEWLPDEDPNEVVGIFAWGVPTPEDH
>NC_013947.1|WP_144300639.1|5561694_5562372_-|hypothetical-protein
MPARVLRKPATRFDTMYPPTQGEAAAPRPFHRLLFLVGGGLAAVIGAYLLTAPLAPGGATITTAIGIQPAVALPMMLLGFLIPAAVGAALGFFARRFPAIVAIVGIAVMAIGISVSGIAPNFLLLVAGSVVTGFGAGAVWGSVTVVALAAGGNKVVELSVLGGAVVLALAVGPFVSGAINMSLSFRIGHYMTVPPLLVALVIAIIAAAARDNRTMPQQTTVQPGP
>NC_013947.1|WP_041626895.1|5562399_5562675_-|helix-turn-helix-transcriptional-regulator
MLQAFKALAHPVRLGMLRRLAAAGEICACDFTDDFDISQPTVSAHLRTLREAGLVTTRRDGTTICYSLVPEALSELGDQLARIGDTAATVA
>NC_013947.1|WP_013020445.1|5562959_5564183_+|DUF4243-domain-containing-protein
MTDETQRQQNPDEARRQQQNSEETQRRQDPEKTQRQQDPDAAQRQVPDEGLRQQNSDAAQRQQILDEALLRLHTTGPEFDDWLSNHAPMAVEALAHHGHADRVHHWIDEYEHVLEEAPRPSDPITVENWREALGDPRRLGDWPSWFDNELAEAEWTEVLARWWPRLLPGIVASATHGVIRVGHAVRTLREQGPNEARLAELARAFGYWAARWQPMVRPTAPSGGLDAASALARVPRIPEQDGGIRDRLAQLDGLAGWESAQAALRLPGEAEAVPDAVRAIVTAAVNRYLSHGHGSAVMLVHAATAPNAVLRVLPSLPREHWHDSAAFAWSASAAVMSIYAPAEAAPTTELPQAPDGSGAEEEIFDAAAANGDAHVIKFADTALDVRSWTGDATPLAAALRSAQLIGD
>NC_013947.1|WP_144300860.1|5564775_5565006_+|GNAT-family-N-acetyltransferase
MGVHGTDAIAHGIMTEPAHRRRGLGSVVMSALSRKAIELGADTGLLVAVPEGRYLYNKIGWSERADFVSGSPPEWA
>NC_013947.1|WP_013020447.1|5565009_5566755_-|protein-kinase
MRAGQVLNGRYRLVERVGLGGMGEVWSATDTTLDRTVALKLLRADLSDDVDSRRRFQQEARYLAKLAIPGAARIHDVGEDQLDGDTVTYLVMEFVPGRTLARLLAERGTLSAAELLPLLEQVARALDVAHRNGIVHRDIKPGNIMVDDDGRATLLDFGIARAVGDAKVTLSGQIMGTLSYVSPEQVNGDAIGPESDVYSLGAVAFECLSGTPPFTGAAVDILSGHLRTPPPDPPPATPRSVARAVKRALAKAPQDRFLTASDFVADCQGGLPDTKPERRRGNRRVLTRATMVTAAILAVALVVTVVVVGLWRPGSGDLSTPDEGGKSSPGWVPEGLEDGTLLDSHDGVIYRVDSDGHVSWYRHTDPKAGAPTWAEGSGKRVGGDWKGRTVIAANRGVLYAIDDNGDLYWYRHTDPKGGADKWSKGSGTRVGHDFDKYIRIFAASANVLHTVDKKGRLFWNKHTSPDDGPVEWQPDSGTEIGSGWNTPMATLVSGGDGVLYVTRPNGDLLWHAPRDFRDVSSPWDRITIAEGWDDYESFVASSTGVIYARTRDGKLYWFRHLNPDNGLDEWSSDKGKLLNPS

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Crispr_ID: NC_013947_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_17

5945707-5945798

Orphan

Consensus_repeat	Method
CGAAGCTCGCGGCTGGGCAGGTGAGCCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_17

>merge|NC_013947|17|5945707-5945798|CRISPRCasFinder
CGAAGCTCGCGGCTGGGCAGGTGAGCCAAATGCCGGAAGCGGGCGGGACAGCTGGCTCCGGCTCGAAGCTCGCGGCTGGGCAGGTGAGCCAA

>NC_013947|17|16|5945707-5945798|CRISPRCasFinder
CGAAGCTCGCGGCTGGGCAGGTGAGCCAA	ATGCCGGAAGCGGGCGGGACAGCTGGCTCCGGCT
CGAAGCTCGCGGCTGGGCAGGTGAGCCAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013020789.1\|5938657_5939443_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|272861
NC_013947.1\|WP_013020800.1\|5948999_5951294_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340391
NC_013947.1\|WP_013020793.1\|5941810_5943385_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|366675
NC_013947.1\|WP_013020786.1\|5934974_5935751_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|224276
NC_013947.1\|WP_013020788.1\|5938259_5938610_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319903
NC_013947.1\|WP_013020801.1\|5951475_5952183_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223487
NC_013947.1\|WP_013020799.1\|5948601_5948997_-\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|214939
NC_013947.1\|WP_013020794.1\|5943496_5944939_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_013947.1\|WP_013020804.1\|5954841_5956023_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380571
NC_013947.1\|WP_041625221.1\|5941172_5941799_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_013947.1\|WP_041625222.1\|5947365_5948511_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_013947.1\|WP_013020791.1\|5940502_5941024_-\|EXLDI-protein	unknown	unknown	gnl\|CDD\|275138
NC_013947.1\|WP_013020797.1\|5946934_5947306_+\|DUF4180-domain-containing-protein	unknown	unknown	gnl\|CDD\|379371
NC_013947.1\|WP_013020802.1\|5952172_5953864_-\|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease	unknown	unknown	gnl\|CDD\|223488
NC_013947.1\|WP_013020805.1\|5956240_5957251_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NC_013947.1\|WP_013020785.1\|5933758_5934964_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NC_013947.1\|WP_013020796.1\|5946235_5946883_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_013947.1\|WP_052305331.1\|5953863_5954739_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
NC_013947.1\|WP_041627045.1\|5939439_5940372_-\|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|130256
NC_013947.1\|WP_013020787.1\|5935779_5938191_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|276809

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013020789.1\|5938657_5939443_-\|ABC-transporter-permease	gnl\|CDD\|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	4.70055e-16
NC_013947.1\|WP_013020800.1\|5948999_5951294_-\|sensor-histidine-kinase	gnl\|CDD\|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	1.55568e-14
NC_013947.1\|WP_013020793.1\|5941810_5943385_+\|FAD-dependent-monooxygenase	gnl\|CDD\|366675	pfam01494, FAD_binding_3, FAD binding domain. This domain is involved in FAD binding in a number of enzymes.	1.1343e-98
NC_013947.1\|WP_013020786.1\|5934974_5935751_-\|DinB-family-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	8.93224e-10
NC_013947.1\|WP_013020788.1\|5938259_5938610_-\|VOC-family-protein	gnl\|CDD\|319903	cd07238, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.21221e-44
NC_013947.1\|WP_013020801.1\|5951475_5952183_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	1.03452e-113
NC_013947.1\|WP_013020799.1\|5948601_5948997_-\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|214939	smart00960, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	1.25e-11
NC_013947.1\|WP_013020794.1\|5943496_5944939_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.04379e-56
NC_013947.1\|WP_013020804.1\|5954841_5956023_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380571	cd06348, PBP1_ABC_HAAT-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.	7.76212e-122
NC_013947.1\|WP_041625221.1\|5941172_5941799_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	5.04434e-08
NC_013947.1\|WP_041625222.1\|5947365_5948511_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.59847e-39
NC_013947.1\|WP_013020791.1\|5940502_5941024_-\|EXLDI-protein	gnl\|CDD\|275138	TIGR04342, hypothetical_protein, EXLDI protein. The most conserved region in this protein family is the C-terminal pentapeptide, with motif ExLDI. Members from the Firmicutes average about 120 amino acids in length, while members from the Actinobacteria have an additional 45-residue amino-terminal segment not included in the model. In it is suggested that the member from Streptococcus mutans UA159, and its homologs, participate in bacteriocin production, export, or immunity.	2.39694e-40
NC_013947.1\|WP_013020797.1\|5946934_5947306_+\|DUF4180-domain-containing-protein	gnl\|CDD\|379371	pfam13788, DUF4180, Domain of unknown function (DUF4180).	7.13935e-49
NC_013947.1\|WP_013020802.1\|5952172_5953864_-\|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease	gnl\|CDD\|223488	COG0411, LivG, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	1.1152e-101
NC_013947.1\|WP_013020805.1\|5956240_5957251_-\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	6.08087e-28
NC_013947.1\|WP_013020785.1\|5933758_5934964_+\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	7.86798e-29
NC_013947.1\|WP_013020796.1\|5946235_5946883_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.46611e-73
NC_013947.1\|WP_052305331.1\|5953863_5954739_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	2.01765e-68
NC_013947.1\|WP_041627045.1\|5939439_5940372_-\|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	5.98933e-109
NC_013947.1\|WP_013020787.1\|5935779_5938191_-\|ATP-binding-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.00148787

>NC_013947.1|WP_013020794.1|5943496_5944939_+|serine-hydrolase
MKRIVIAVAAAALLVTPGVAAAKPHSGLDERSVDAFVGEYLENAGVKGVTVAVTKGTDVVVAKGYGTDSTGAELTGEAPMPIASLSKSFTALAVMRLSEQGKVDLDAPVREYLSEFTMDDPRAKRITVRQLLNQTSGMSDGTFSEKVEAQPSDLAGSVSRLADAELATAPGKSWNYHNPNFHVAARLVEKVSGEPFGEYLDTEVFAPLGMTKTSTVDVTDDAKLPRGHFAAYGQRAAAEPHRFVNGSDGIISTAEDMANWLAVNNGDGGELVSAKGFAELHEPSDPRGRYALGWNVGKRDGATVLDHGGVWFTYTARQLVIPETGYGFAVMANTGMSMAADVPYDLTEGLMALSEGDQPSTTDSPQSTNDLVLGLLTLAAIGWAAWRWYRSGVWARRRVDRPLWRNVLAGSRALFPALVLLSYPWLAGLVAAGRTATWTEHLYVWFPMLVWLSIATLGGLLVTGVRAVRLVRLRRSRATT
>NC_013947.1|WP_013020793.1|5941810_5943385_+|FAD-dependent-monooxygenase
MTNDETTTVLIVGGGYAGLTSSLFLSHLGVPSILVDKHPGFSIQGRARGITPRTMEIYRSIGMEAEMIEAGRPFADDKGGAYCETLAGEWGWLFPPEAATSFPDLTPSTFNLADQSAAEPVLSEAARKHGAVQHFNTELLTFTDDGDGVTAEVVDRADGQRRTIRADYLIAADGQRSPIRERLGIKRSGPGIVRHHLGCVFDADLSKYVKQRAILWFIRNEEIGGMFLTTTAEPGRWGMAVDYDPETETVDSFPDERCVAVIRGAVGDPELQVTVRDKQTWSQGVAVSDEYRRGRVFLVGDAAHVWSPAGGIGANTGVQDSYNLAWKLAAVSKGWAKPGLLDSYHPERHPLAEVLAELTEERQHNRINDPENDKADDLLWNFGQRYLSGAMIGADHDSVFGDSLDLRGQPGTRAPHLWVEQDGQLISTHDLFSRGFVLFTGAGGGAWTDAATHVCETEGIPLIGYRVGAEVELVDVDGAWPDRYRLGEDGAVLIRPDGYVAWRHEGPAGEPREALSGALRTILG
>NC_013947.1|WP_041625221.1|5941172_5941799_+|PadR-family-transcriptional-regulator
MTTPPRRSALALTVLVFLAWESMHAYKIQQLIKEFGKDRVVNVKQRASVYQTIDRLLRTELIRVRETSSADNRPERTIYEITDTGRDTARRWLREALASTGNEYPEFPAALAQLPLLPPSEVAEQLQVRLDAQRAEYAQMSEWFDQDPPQLHRLFLIEEEYRFAVLTAEIGWLESTIADLRSGALTWDETWLRQQAQPYSSENPDTNP
>NC_013947.1|WP_013020791.1|5940502_5941024_-|EXLDI-protein
MPNKTIYVSDDDLPLFQRAQELAGGKLSTAITAALRRYVEIAEGRMEGFEEVTVRVGAGVGRKVRFSGILLAEWGHSTSSRVDDYRVYRTRTGKYAVHIERSDEHYWSGQDAANWVEWVRAQFKTEQTWGYKAGEGVLEIAEDLEDLRDKIPAELHDIVASAVEQPPIEDLDI
>NC_013947.1|WP_041627045.1|5939439_5940372_-|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein
MEVAGLRKSYGDHLVLDGIDFTVPTGSIFSMLGPNGAGKTTTVQILSTLIKPDAGVIRVAGHDLAAAAQSVRGAIGVTGQFSAVDNLLTGQENLRLMADLNHLTRAEGRRRSAELLERFELTDAAAKQPATYSGGMRRRLDLAMTLMGDPRLIFLDEPTTGLDPAGRRVMWRIIRDLVDEGVTIFLTTQYLEEADQLADQVAVLDKGTLVAQGTPAELKRLIPGGHITLRFNDVQDLDTAANTLTVSARDETALTLQTPSEGDMKSLRALLARLDAAEIEPADLSIHTPDLDDVFLALTGHDATTKDSSQ
>NC_013947.1|WP_013020789.1|5938657_5939443_-|ABC-transporter-permease
MSTYVIRDSTAMLRRNIKKAIRYPSLTLMVIGMPIIFLVLFVYVFGSTLGDGLGGTSGGRDAYLTYVTPGILLFGILGSVQGTAITVSMDKTEGIMDRFRTMAISRSSVLTGHVIGSLIQTVLGTAVVMAVAVALGFRSDATPLEWLGVLGVMVMVSFAFIWMSVLVGLIAKTVESASNIPMPLMMLPFLGSGFVPTDTMPAGLRTFAEYQPFTPVNETLRGLLLGTEIGDSAWLAVAWCAGISLVCFLLARRRFNRPQTR
>NC_013947.1|WP_013020788.1|5938259_5938610_-|VOC-family-protein
MSIRRAVPDILTDDMDATRAFYAGLGFEEAMDLGWVVTMASTSNPTAQVIFFDRARVEGPQPDMSVEVDDVDAVHAAMTATGAEIVYSLRDEPWGVRRFFVRDPNGRVVNVVTHQA
>NC_013947.1|WP_013020787.1|5935779_5938191_-|ATP-binding-protein
MDPVSSFFVTRWATTATDRAARRFSEAIRGTEVQRALVTAVKNAIPKAAARLHPDDDSLAGHVADCLWERDSHALPLVDGTALIDLADAVAPWVDEVYTPVGETPDAGPEPSLLARLLREEIIAAVRAEATAGDRVLHALWSDYQNESILRRVARPRATEPGRLDWGRLPLPGTFVGRREQLETLADMRSESGLGLIVSVGGFGGIGKTALASWFAASVRCSYPDGCVFVDFQSYPSPDQAVSSYAALGMLLEHLFGLEAATVARMDLAARGAEWQRRVAGKRMIFVWDNVSSIDQVEPLLVRDPDCLTLITSRERFHCAGSRTLDLDVLDHDAAVAMFVAVAGPRLAADEAAVSRVVTACGHMPVLIGLKAADIACGTGSLDRIEVQLNNLPSAHTKAGLYARIDSSYAALTAEQQAAYRLLGKHPGRYLTVGTTTIVLSRLIGRSVTVAEAVALLDGLVAHRLAEPMVTDPPASIAEQLAYTAHDILLDHAAGLPAATGEPEILSTVCDYYADRLAHYDFVGDLAWFRTERSALVAALTSPAARPHATLNLAQLMLTNDNIGLAIDILRELLDGFVATGDSRGEVNTLQTLGQAVLVTGDHEGARDLFTKAGHLAEEHGFRDCAAHAYLGLAQVKALNDSPVGIADMFERALDIFVDLDDVTNATNALAGMAQVAMLQQDFDAARSIFVEIEDTSEVRAYGMGVALGVLGQAHVAYLDGDNDEAIRLYQRGEEASESVGYRFGVGMARECLGEIAAETGDVEGAIAHFRGALTVYVEIGSPSQHEVREALRNLGVPAEPPD
>NC_013947.1|WP_013020786.1|5934974_5935751_-|DinB-family-protein
MNEFRGQDLSGARFEDVMLTGAEFHDIDLSDARFRLVSLKGASIRGADLRDLDLSGWIGNLRVNGVDVAPLVEAELDRRHPERAKMRPTDAAGYREAWRILERLWGQTIERARGFEPWQLHESVDGEYSFIETLRHLNFAPDAWVGRAVLGDPTPWHPLDLPHDEMPDEPSVPRDRDARPTLEEVLAVRRERVAMVRRVLDELTDEKLVTATEPVTEPGYPESQSFPMTRCLGAVINEEWEHRLYAERDLDVLAGKTT
>NC_013947.1|WP_013020785.1|5933758_5934964_+|FAD-dependent-monooxygenase
MSRPRVLIIGAGLGGLALAHGLRDAGVDHLVVERDASVRSRRQGYRIHINADGSTALYEVLPKRLWELFRATASIPGPVGEFYDHRFDVVHRFEADGSARTVHGLPEHLNVNRLTLREILATGLDTVRYGRTFTGYRRDADGRVVAHFADGGTETGDLLVAADGVHSRVRRQRLPHARVVDSGLRLIYATVPLTPATRPLFPEGMFGGYSAILGPKHRHLGGAPVEFAEPLSRTASRIAADASLTEHRSYMTSAFGARVEDLPDDEELFAMNPSALRGLALDMMDDWHPRARRMVEHWELSSVLPLLLRTSVPTEPWPASEVTLLGDAVHAMSPAGGSGANAAMLDGAILAARLREVRDGKPLLEAVAEYENAMREHGFAAVRMSADNGHRMLGQDPLPPA
>NC_013947.1|WP_013020796.1|5946235_5946883_+|response-regulator-transcription-factor
MIRVLLADDENMVREGVKSILTTDAGIEVVAEAGNGREAVELARAHRPDVALIDIRMPVLDGLGALAELRQAAPATRCVMLTTFDEDEFIARALDAGAAGFLLKASDPRELIIGVRAVADGAAYLSPRVAGRVIAEFDTDRLTRGTGAQRKVAELTPRENEVLGLIASGLSNQEIGRRLHLTEGTVKAHVSAILQRLGVRNRVEAAIIGYQAGLA
>NC_013947.1|WP_013020797.1|5946934_5947306_+|DUF4180-domain-containing-protein
MTAMVTRQNGTTVLKLPADGPQLREVEDFVDLLGEAMANEADLVVIPADRIADKFFQLRSGLAGEVTQKFVNYRTRLVIIGDISTHTADSSALAAFVAESNRGDQLWFLPDRATLDDRLADGD
>NC_013947.1|WP_041625222.1|5947365_5948511_-|serine-hydrolase
MTNDRAALREALEWGVEQGAPSVAVQVSDADGTWFDAVGKSDLVTGAEREPGEQLHTGSISKAFTAVAALNLAAEGRLSLDDTVEKWLPGTANGNGYDGSTITLRHLLNNTSGLFATGMAVEVQNRYNKRSAFDKHRHDVWEIDDVLKLAVSEPPVGEPGEKFWYSNGGFGFAGAIIERASGASLESEVERAVRPLGLANTFMRERADEGYRGPHPKAYSKLFVKEGVRPEDVTAENWQSMMEGPELEPFDTTDVNTSGGYGAANVVSNFDDLLVFYKALITGSLLPQEQNAELWNTVSTKGGYWMLNSRYGLGVCELTLSDGQKVRGGGGQSFGTITLVLGSPDGERMVAMHTNNDWLTFPVFDRITEAVFGANGIGLEG
>NC_013947.1|WP_013020799.1|5948601_5948997_-|roadblock/LC7-domain-containing-protein
MYNGEDLNFLLNDFVTRVPHVTHVIAVSADGLLVARDDALPQEQGERLSAIASGLVSLLAGAARSLQADPVISNLTQTQEGFMFSMSAPGGASLLALSDKSCDIGQVGHELATLINQVGDSLTSPARFGRG
>NC_013947.1|WP_013020800.1|5948999_5951294_-|sensor-histidine-kinase
MRIGSKLALILLIPLVALSGVVAVRLVDSTLEALRIGDTARVVELTKTVAETLSALQEERHQMAVQIYGDELNLDEDQRDLRHLDEAVYATDEKLGALKQARETFEGDAEVREQLEQADKPLNRLDRVRSAELDESEEVYLTVYDAAVRRLMRVLDRAVDLVDDAELSRRVRAASLLASADEYSERLRVLILQLPDGKPLAAAYRPFMTLSLSRSQTMSEYRRIGGEAVFEAGGLGGGAARPANSLESTVATSRTDENVDIDHAELMGAYDARHKDTATYVDDTQDSAVTLARSIRDDVVLRVLIETVIVLLTVAVAVMATLWLGRPVIRGLRQLRDSARRIAYEELPTAVKQVSEHEGLAGLTPREFADNTAAPLKTQGAAEIIEVGEAFDDVHHEAIRVAAEQALLRVHIGTMFVRLARRGHSLTGRLTATLDEAERDEQDPNRLQLLFRLDHLVALLGRANDSLLVLGGAAAARVRTSDEKLNDVLTAAQSHTEHYTRINVTTVDEGVWISSTAVEDVVQILAELMDNATQYSRHPTEVIARYLTDRVVIQIRDYGIGIDPQRMSRYNARLGTRAPLDLEAMQSMGLTVVGQLAKRHGIQVRLQPATESSGTTAEVVLPHSILRFARDLTQQRQLSNAAPADATEAPLFRGGLLGIGSGPATVPDAAAGLPVIHFEWQTVHADSSLRAGAALPSRETTYDEVTGLPRRRPRSQLVPGAVAPTHDRPDAPARRDPEAIGATYTAFARGLFGDAGASPTDSRS
>NC_013947.1|WP_013020801.1|5951475_5952183_-|ABC-transporter-ATP-binding-protein
MSDELLRVDGLHVSYGRVRAVRDVSFTAPRGELISLVGANGAGKSSVLGAVSGLVRPKSGTVHYDGANITRWPAHRRVAAGMVLVPEGRQILTTLTVAENLLLGGWRRRRAAATIAEMYELFPVLAQRRDLSAGTLSGGEQQMLAIARAMVAQPRVLLMDEPSMGLSPKLVDEVFRVIETIRATGVTIVLVEQNARRALRAADTGYVLETGVVSHSGPAPRLLADRRVVDAYLGG
>NC_013947.1|WP_013020802.1|5952172_5953864_-|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease
MFDGYESLLTTIALTGILAYSFHIVLMSGQLSLGQAGFASLGAYTSALVVPETPLFGSLSPAIVGIPVGAAVGAAAAVLLGLPVLRLRGVFLAIATIAFAEVVRIYMVNASWTGGPEGMYLDKWVTPELAWLALILVAYTVWRLGPSRMGRALAAVREDEVAAGAMGINVSRARMAAFTASGALAGMYGSLFAFFARGIEPGDFNFTMMLDGLVTAIVGGFLVFFGPIMGSGFLNLLPELQRATGLEAGWMHPFVTGALLLLVILFLPGGLSSLLTWIRPRTKPLGSAGAAPPVLPPLPAAGIPILELSGLGKDYGGVHAVRGVDLTVRSGEILGVIGPNGAGKTTLVNMISGLTAPTSGTGEVLGVRLGNRMRPHRLAGAGVSRTFQHSKLFGRLSVLDNALIGTHVVCRPTFLRRLLWLPSARADERRAVAQAMTQLERVGLDDKSHLAADELSYGDQRRLEIARALASHPSLLILDEPAAGMNHVEASDLSKAIRSVADEGITVILIEHNVRMVIDTCTRVAVLNFGEVLAVGDPVAVAADPEVIGAYLGAEDPEDTHVR
>NC_013947.1|WP_052305331.1|5953863_5954739_-|branched-chain-amino-acid-ABC-transporter-permease
MQQLANGLFSGAIYALFAIGFTLVFGILRHLNLAHAAIYTAGALIGIELVEGQGLPLWLAFPLAILAGTALGLILERSAFRPLAGRRDEHFAGLISSVAFGGMLIALLQARFGSEPRSFSQSAFPNEILTIAGVTVSLAQLLTLGLALALMLGLAWLLSKSALGRAMRAVAENPRAARVLGINVEGVTAGTYALSSALGSCAGVLMALNVGQGDLRMGLSIELTGFAVIILGGLGSLWGAMAAGLLLGFAEAFTVHLIDSTWKNVVAFVLLFVILLTRPQGLFGQVKTREV
>NC_013947.1|WP_013020804.1|5954841_5956023_-|ABC-transporter-substrate-binding-protein
MRIRIASATAIVAATLLLTGCVESSTGNDKAEGNLVGKGEGAKCQIEDPVKVGAVFSLTEAAAFAGTYQKEGLELAFKELNKKDGVEYELIQEDDKTDVKASLAAFEKLIDREKVSAIVGPTLSNLAFKTYQDAEQAGVPALGVSTTAEGIPDIGDYIFRNSLPEQYALAASIPAAKDALDLKKVAVLHDEQDEFTASAYKTMKETLKEAEIDIVADEQFQTTDTEFRSQLTNVKSAKPDALVLSALPGATIPLVKQARELGIDAPIVGGNAFNSPVLIKQLEDAAEGLIVGGAWSAKTETPGNAEFIKAYKKAYDKDPDQFAAQAYTAGFLIDEAVRTDCDGNRDAIKDNLGQILKFDTVLGKLSLDETGEVHQEPVVQIVEDGKLTPLKKK
>NC_013947.1|WP_013020805.1|5956240_5957251_-|amidohydrolase
MKIDAYSHILPAPYFERMRQLVANPGMFKRWLELPALHDIDVRLRMMEEFGDDYQQVLTLSSPPIEVLATPEQSPGLARLANESMLELCQKYPERFPAFVASLPMNNPDAVFEELDYAIDELGARGVQVFTNVNGKPLDEPEYLEIFERMAQRDLPVWMHPARGPGHADYLTESTSKYEIWWALGWPYETSVAMSRLVFSGILERYPDLKIITHHMGAMIPSLEGRIGLGWSDQLGSRTAEVDYAKLREERLPLPLVDYFRRFYADTALSGSAIGVRCGLDFFGAERVLFGSDCPFDPQGGPMYIREIIRVVDELDITDAERECVYHRNVRGLMRL

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Crispr_ID: NC_013947_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_18

6051492-6051596

Orphan

Consensus_repeat	Method
GGTGCTGGTCGCCGTCATCGCCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013947_18

>merge|NC_013947|18|6051492-6051596|CRISPRCasFinder
GGTGCTGGTCGCCGTCATCGCCGTGCTGGTGGCGCCGTCGCTGCTGAAGTCGTCCATCGTGGTCATCGCGGCCTGCCTGGTGGTGCTGGTCGCCGTGATCGCCGT

>NC_013947|18|17|6051492-6051596|CRISPRCasFinder
GGTGCTGGTCGCCGTCATCGCCGT	GCTGGTGGCGCCGTCGCTGCTGAAGTCGTCCATCGTGGTCATCGCGGCCTGCCTGGT
GGTGCTGGTCGCCGTGATCGCCGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013020885.1\|6046981_6048232_-\|deferrochelatase/peroxidase-EfeB	unknown	unknown	gnl\|CDD\|273606
NC_013947.1\|WP_041625226.1\|6046410_6046713_+\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020897.1\|6058257_6059604_+\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592
NC_013947.1\|WP_013020898.1\|6059737_6061321_+\|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|376850
NC_013947.1\|WP_013020881.1\|6042914_6043970_-\|iron-containing-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|341453
NC_013947.1\|WP_083787409.1\|6055284_6055986_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|131997
NC_013947.1\|WP_013020882.1\|6043957_6044686_-\|phosphocholine-cytidylyltransferase-family-protein	unknown	unknown	gnl\|CDD\|133014
NC_013947.1\|WP_013020880.1\|6042043_6042928_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224596
NC_013947.1\|WP_041625225.1\|6046023_6046320_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_052305175.1\|6044916_6045906_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|99777
NC_013947.1\|WP_013020889.1\|6051636_6051867_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020896.1\|6057571_6058261_+\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|235486
NC_013947.1\|WP_052305176.1\|6053974_6054793_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013020895.1\|6056697_6057333_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NC_013947.1\|WP_013020890.1\|6052034_6052979_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NC_013947.1\|WP_013020879.1\|6040553_6041978_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NC_013947.1\|WP_013020886.1\|6048253_6049384_-\|peptidase-M75-family-protein	unknown	unknown	gnl\|CDD\|271139
NC_013947.1\|WP_013020891.1\|6053073_6053970_+\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379142
NC_013947.1\|WP_013020894.1\|6056369_6056609_+\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|368604
NC_013947.1\|WP_144300877.1\|6049407_6050259_-\|FTR1-family-protein	unknown	unknown	gnl\|CDD\|272930

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013020885.1\|6046981_6048232_-\|deferrochelatase/peroxidase-EfeB	gnl\|CDD\|273606	TIGR01412, Probable_deferrochelatase/peroxidase_EfeN, Tat-translocated enzyme. This model represents a small family of proteins with a typical Tat (twin-arginine translocation) signal sequence, suggesting that the family is exported in a folded state, perhaps with a bound redox cofactor. Members of this family show homology to Dyp, a dye-decolorizing peroxidase from Geotrichum candidum that lacks any typical heme-binding site.	4.7896e-169
NC_013947.1\|WP_013020897.1\|6058257_6059604_+\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	2.31355e-150
NC_013947.1\|WP_013020898.1\|6059737_6061321_+\|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase	gnl\|CDD\|376850	pfam02602, HEM4, Uroporphyrinogen-III synthase HemD. This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as HemD with pfam00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease.	8.5153e-63
NC_013947.1\|WP_083787409.1\|6055284_6055986_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|131997	TIGR02952, RNA_polymerase_sigma-70_factor_ECF_subfamily, RNA polymerase sigma-70 factor, TIGR02952 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is found in a limited number of Gram-positive bacterial lineages.	2.48257e-72
NC_013947.1\|WP_013020882.1\|6043957_6044686_-\|phosphocholine-cytidylyltransferase-family-protein	gnl\|CDD\|133014	cd02523, PC_cytidylyltransferase, Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline. This family contains proteins similar to prokaryotic phosphocholine (P-cho) cytidylyltransferases. Phosphocholine (PC) cytidylyltransferases catalyze the transfer of a cytidine monophosphate from CTP to phosphocholine to form CDP-choline. PC is the most abundant phospholipid in eukaryotic membranes and it is also important in prokaryotic membranes. For pathogenic prokaryotes, the cell surface PC facilitates the interaction with host surface and induces attachment and invasion. In addition cell wall PC serves as scaffold for a group of choline-binding proteins that are secreted from the cells. Phosphocholine (PC) cytidylyltransferase is a key enzyme in the prokaryotic choline metabolism pathway. It has been hypothesized to consist of a choline transport system, a choline kinase, CTP:phosphocholine cytidylyltransferase, and a choline phosphotransferase that transfers P-Cho from CDP-Cho to either lipoteichoic acid or lipopolysaccharide.	1.07638e-56
NC_013947.1\|WP_013020880.1\|6042043_6042928_-\|ABC-transporter-permease	gnl\|CDD\|224596	COG1682, TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	9.99443e-46
NC_013947.1\|WP_052305175.1\|6044916_6045906_+\|response-regulator-transcription-factor	gnl\|CDD\|99777	cd06170, LuxR_C_like, C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.	3.16254e-13
NC_013947.1\|WP_013020881.1\|6042914_6043970_-\|iron-containing-alcohol-dehydrogenase-family-protein	gnl\|CDD\|341453	cd08174, G1PDH-like, Glycerol-1-phosphate dehydrogenase-like. These glycerol-1-phosphate dehydrogenase-like proteins have not been characterized. The protein sequences have high similarity with that of glycerol-1-phosphate dehydrogenase (G1PDH) which plays a role in the synthesis of phosphoglycerolipids in Gram-positive bacterial species. It catalyzes the reversibly reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in a NADH-dependent manner. Its activity requires Ni++ ion.	2.37796e-148
NC_013947.1\|WP_013020896.1\|6057571_6058261_+\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|235486	PRK05472, PRK05472, redox-sensing transcriptional repressor Rex; Provisional.	5.8087e-107
NC_013947.1\|WP_013020895.1\|6056697_6057333_+\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	1.29513e-14
NC_013947.1\|WP_013020890.1\|6052034_6052979_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.73572e-54
NC_013947.1\|WP_013020879.1\|6040553_6041978_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	5.70742e-162
NC_013947.1\|WP_013020886.1\|6048253_6049384_-\|peptidase-M75-family-protein	gnl\|CDD\|271139	cd14656, Imelysin-like_EfeO, EfeO is a component of the EfeUOB operon. This family includes the EfeO domain, an essential component of the EfeUOB operon which is highly conserved in bacteria. However, its biochemical function is unknown. EfeO contains an N-terminal cupredoxin (CUP)-like domain and C-terminal imelysin-like domain that may bind iron. Algp7, a member of EfeO family protein from Sphingomonas sp. A1, is found to bind alginate at neutral pH, but does not contain the CUP domain, thus having a role that does not seem to be related to iron uptake. Some members of this family are fused to an N-terminal putative EfeU ion permease domain. The imelysin-like domain of this family also contains the GxHxxE sequence motif and a highly conserved functional site, suggesting a similar role to other imelysin family proteins containing the same motif.	1.16834e-94
NC_013947.1\|WP_013020891.1\|6053073_6053970_+\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	8.95661e-05
NC_013947.1\|WP_013020894.1\|6056369_6056609_+\|glutaredoxin-family-protein	gnl\|CDD\|368604	pfam05768, DUF836, Glutaredoxin-like domain (DUF836). These proteins are related to the pfam00462 family.	4.78709e-16
NC_013947.1\|WP_144300877.1\|6049407_6050259_-\|FTR1-family-protein	gnl\|CDD\|272930	TIGR00145, Uncharacterized_protein_slr0964, FTR1 family protein. A characterized member from yeast acts as oxidase-coupled high affinity iron transporter. Note that the apparent member from E. coli K12-MG1655 has a frameshift by homology with member sequences from other species. [Unknown function, General].	3.7319e-52

>NC_013947.1|WP_144300877.1|6049407_6050259_-|FTR1-family-protein
MFATFLIGLREGLEATLIVSILVAYLVKSDKRKYLPHVWGGVAAAVVITVIAWAVQHYGTRELTPDGRELFEAITSILAVCFVTWMIFWMRKAARRIAGELRAKLEQAIKMGPVAVVTMAFLAVIREGLETAVILETQTTASQGGTEALLAAIVGIAVSVAIGVGIYYGAVKINLSRFFTWTGVLLIFVAAGIFKYGIHDFQEVGALPGLNTFAFDISGWYAQDSWYGNLLEGMFNITATPSVVETIAWVAYVVPALTFFLWPSGKKPAPAAAPKSEETASAS
>NC_013947.1|WP_013020886.1|6048253_6049384_-|peptidase-M75-family-protein
MRKPVFAVAVAALALTATAACAEKAKESDDGPIAVTATDDSCEVASTKAKAGTVTFKVKNDGKKVTEFYVYAKGDRVMSEVENITPGNTRELIVELPAGKYETACKPGMVGDGIRGKFTVTGKAEKLTEDENLADAVKSYKRYVAKQSEALVDKTGEFVDAVKDEDIDKAKELFPISRTYWERIEPVAEIFGDLDPRVDAREDDFPKGPKDPEFGGFHKLEYDLWITKDVSKSGKVADQLLKDVKEVVDRAEKEELTPLHLANGAKELLDEVATSKITGEEDRYSHTDLWDFAANLAGSEAAVASLRPVIDEKDPKLGKKLDEKFAAAEEALGEHAKGDGWRLWDELSKSELKELSDAINALGEPVSEVAGVVSKK
>NC_013947.1|WP_013020885.1|6046981_6048232_-|deferrochelatase/peroxidase-EfeB
MERRKLFSLGAAGAAAVGTGFAAGQLVQVSPAVADGNDAANPVRFYGKHQSGIATPAQDRLHFTAFDVITSDRDELIGLLKDWTEAAARMCDGDFAGPGGAVGGNYDSPPQDTGEAQGLPASGLTVTVGFGPSLFDKDGEDRFGIGDRRPELLEELPLFRRDDIDPKISGGDICVQACANDPQVAVHAVRNLARIGFGKVSIRWSQLGFGRTASTSSTQSTPRNLMGFKDGTANLKAEETKELKKHLWVGAKDGPEWMAGGSYLVTRKIRMQVETWDRTSLSEQETIFGRDKSEGAPLTGSKEFDEPDFKAKADDELVIGTVAHVRLAHPSQHGGARMLRRGYSFVDGSDELGHLDAGLFFIAYQRDPSKAFIPVQKALADNDVLNEYIKHVSSGIFACPAGVEGPEDYWGRALFE
>NC_013947.1|WP_041625226.1|6046410_6046713_+|hypothetical-protein
MWIRADRTTARGNPRDKVDVGPRSREAEFSVALARPKPATRATREPLDDRGEAELASHVKAEATPARPRLATRAARAPLDDRGKAEFASRVAVDALARPP
>NC_013947.1|WP_041625225.1|6046023_6046320_-|hypothetical-protein
MDSRLTGDGVRSRVAITGDRTISVTDTVVGEVSAVGAADDVFAALASSATRPPPHPAMYPEEGGTADGATHPNRSPGPPNPVWCPPASRRPAPDVRRH
>NC_013947.1|WP_052305175.1|6044916_6045906_+|response-regulator-transcription-factor
MSTMPRSWQRLLDGVGLTAAAERVYRAILADPRASPATLAEAAAVDAAALPELCELLRGLGLIDTEDDGTARPVDPRIGMSALLRRQQDGIERAVAAVTDLTDDFLDGQTRIGASPLTELVRGRHHLETTIRALITSARSEVAVLDTPPYAAANSIEPAEEFSLESGVSNRAIYAAEVLENPELYDNIRKMTAAGEQARMLPEVPLKLLVVDGSRALLPITLEGDVSNSAVLVHPSALTTALTALFEALWAKALPIFDPVGATHGPLDPEERELLGMLASGVKDEAIARRLGISNRTVSRRVNRLLERLGAANRFQAGLQAARQGWLEG
>NC_013947.1|WP_013020882.1|6043957_6044686_-|phosphocholine-cytidylyltransferase-family-protein
MRGVVLAAGQGQRLKPDTDDLPKTLLPVDGDVTILDIALRNLAAAGVGEVGIVVGFAAHAIEARVEALRERYGLTIELIHNDRTDWNNAYSLWHARDFYAQGALLVNGDTVHPGSVEKTLLAAEGDGILLATDAVKELTDEAMKLQCGADGVVTTVTKQMPVESAYGEYIGVSRIGADIAAELTDALVRTYTSDPNLYYEDAFQLLADAGPNVHAVPIGAVDWVEVDNHADWAVAREVACRC
>NC_013947.1|WP_013020881.1|6042914_6043970_-|iron-containing-alcohol-dehydrogenase-family-protein
MPLLARTVTAPLAVEVHAGAVRHLGELLADRRISAGGEVAVVVGPGIGKEAAEQARESLARAEVLTIDAGTHGGALELATKLRSRNFDAVVGIGGGRVIDTVKYAAFRQGLPMVSVATSLANDGIASPTASLDRDGHSISYGAQIPIAVIVDLDFVRRAPARQLSSGVGDALSNLCATADWQLSHTETGEPIDGLAIAMSRGGAESVLRHPGSVGDDTFLATLANALVLGGTAMAVAGTSLPASGACHEIAHAIQERHPTVATHGEQVGMGALFATYLRGDEQLFREMAHAMKRHHLPRIPSDMGLTVDQFAVAVAYAPKTRPGRYTILEHLSLDVSDLRDRITEFCDELS
>NC_013947.1|WP_013020880.1|6042043_6042928_-|ABC-transporter-permease
MNSPDTLVTSRPKRIFPKTTGLTALWRHRQTLRVLVQRDLAVKYQKTVMGYFWSLLEPMGLATIYWFVFGVVMQVGARGDSALEHVDYSLYIVSGIFAWMWASSAISEATTCLTSQSSLITTMKVPREVFPVARVVARFAEFLAGIPIIVIFALLGRGISAGTFGWNLLLLFPAVALQAVLLTGLAFILASLNVLYRDVQRFMRLVTRILFYAVPSIYPLALVLKSDNLPEWAKSIYLANPFVVIVEIHHEAWIPGLNNLTWQMITTSVAISVFLLFFGRWMFHRLEPMVLKEL
>NC_013947.1|WP_013020879.1|6040553_6041978_-|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MRASSTSLPNEGESIVASGSPRPRLTFIGVGPLGGTYAACYAELGYEVLGYDVDSGRIEKFSAGEMPFYERGLDDLVRKNVDNGRLRFTTDPQEVADFGDVHFLCVGTPPRKDSDSADLAYIESAVTTLAPLLTRRCLLVGKSTVPVGTAAWVQQLIDKHSSPDVEVEVAWSPEFLQEANAVDDVLRPNRIVLAAQSEWADELLQAAHKGVFELAAMEDREVPLVKTDFATAELVKVASNAFLSTKISFINAMAELCEASGGDVNALARAMGYDSRIGHRFLRAGIGFGGGCLPKDLRALAARGKELGVGESMRFLAEVEDINLNRRTKVVRLAAELCGRENGPNGPELSGLNITVLGATFKPDTDDVRDSPALDIARRMSNEGATVTVYDPMGMDNARMFRPELRYGHTLTEAVEGADLVCVLTEWEEFRHVDPEALSDLVAKPRILDGRNALDPQLWRNAGWTYRGLGRAAD
>NC_013947.1|WP_013020889.1|6051636_6051867_-|hypothetical-protein
MDNLCPHCGWPDAEPYQVISRRLTRDSTQLSWVRCACGSLQMRQQPRGGEVSVLTRGRPTSDMSNLGNGHSELPSH
>NC_013947.1|WP_013020890.1|6052034_6052979_+|LysR-family-transcriptional-regulator
MIDLRRLYVLRAVSHYGTVTAAAKALHLSPSAASQQIRQLAKELDVTLLEPQGRNVRLTPAAHVLLSHADAIEARWRRAETELHATGAEPAGELRLCGFATAIATLLAATAELLHARYPAMDVRLREAEARECFDLLFSGDADLAIVEANFESPPLDDIRFDQQPLFDDPFDLVTAADHPLAERDSVALTDTARERWILGLPGSTSRQHVLAACSNAGFTPSVAHEAGEWSVAATLVAHNLGIALVPRLAELPPHLALSRVPIAGPHTPYRHFLSCTRRGSREYPTIAAASEAIEEIRAERESVEEGLNNTLIH
>NC_013947.1|WP_013020891.1|6053073_6053970_+|trypsin-like-peptidase-domain-containing-protein
MRIQRSRLARRLTAVSALALVAAVAVATTAAQASADPVGTGTSTATEEKAEKKVKEVNFAGTVALDNCSGSLVTMPNSAPEDKAMVLSNGHCLESGMPGPGEVIVDEPSQRSFELLDASANAVGTLTASKIAYATMTDTDVSLYELTESYAEIKDKYSIDALKVSAEHPKEKTAITVVSGYWQETYACDIDGFVFELREADWVMKDSIRYTEACKTKGGTSGSPVVDNATNEVVGVNNTGNENGEECTMNNPCEVDENGQVTVREGINYGQQTYIITTCVDKGNVVNLELDGCTLPKP
>NC_013947.1|WP_052305176.1|6053974_6054793_-|hypothetical-protein
MSGGRRMIVASALAVGVLGLSGVSTASADALPGDALYPVKRSAERAQLALAGSEVNRGQLYFEFARTRLDEAGRVSGNPEALNTTLSDMDSQLASGMKSLTSAAVNRQDAGVLDTIDEFLDGQSPKLANLLDDAPNEAHTSLGDSMDLMDSAAERSQELREALLCAASFDDDTDKLGPLPGECGVLPGEDGTPLDVPTDDENPASTQETGSGTTGSGDTSTDAESESPSPQPGRKGDKNSDESPSPTSPSPTADNGGGLLGEIGDTLDDLLG
>NC_013947.1|WP_083787409.1|6055284_6055986_-|sigma-70-family-RNA-polymerase-sigma-factor
MLTVDLNPSRVEAPSPASDGDREEPSCNSGEDDSGQPDSQSCSAEVGPAEVRELVARAQDGDVDAFGRIYDRYNEIVHRYIYFRVGNRQLAEDLTSEVFLRALRRISTFTWQGRDFGAWLVTIARNLVADHFKSGRYRLEMSTAEVLDIDREERAPEGNPEDTVCDKLLNVTLLKAVRELNPDQRECIVLRFLQGMSVAETAGYMRKNEGAIKALQYRAVRTLARLLPEGFGR
>NC_013947.1|WP_013020894.1|6056369_6056609_+|glutaredoxin-family-protein
MPRLRLLTTKHCHLCAAAREALGRVAATAGVDWDEVDVADDVALAREYGDRLPVVLLDGREHGYWTVEEARLLRDLNAG
>NC_013947.1|WP_013020895.1|6056697_6057333_+|HAD-family-hydrolase
MAKHLVWDWNGTLIDDFAAVVEATNLAIGTVGGQQLDAATHRERFFRPVADFYSELAGRELPPAEFAELDKLFHQHYHSKLAEHGLTVDARAAIAAWPGTQSLLSMWFHNDLVPLVTEHGLVEHFARIDGLRETVGGNSKHPYLVAHLEALGIDATDCVLIGDSVDDHVAAATAGASCVLYAGGFTSPTRLRATGAPVAESLTEAVALALG
>NC_013947.1|WP_013020896.1|6057571_6058261_+|redox-sensing-transcriptional-repressor-Rex
MPTGDPRANPTADPRDIPDATVARLPEYLHALHTLAEAGLSTVSSEALAAAAGVNSAKLRKDLSQLGSYGIRGVGYDVVMLKQQISDVLGLTRHHSVALVGVGHLGQALAGYAGFANRGFAISALFDISSERVGTMLGGLLVRHLDELPTVVAAERISIAMITTPPLAAQRVADSLVKAGVTSILNFAPCVLDVPGNVDVRKVDLAVELQILSFHEHRKSQGLNEKEAV
>NC_013947.1|WP_013020897.1|6058257_6059604_+|glutamyl-tRNA-reductase
MNLLVVGASHRTAPVDLLEKLAVDSDTVWAMTQRLLAGRYVEEVVVLSTCNRVEIYAAVTGFHGGLVDIADELAELAGMNREALSGHLYIRHETQAVKHAFAVASGLDSLVAGESQILGQLRDAYDTAKESGSVSRMLHELMQQALRVGKRIHSEANVDAAGPSVVSAALDLGEQQWDRELAGSRVLVVGAGAMGALATAATTRRGATSVTIANRDGARAKRLAANHGAATVEWDNLAEAVAQADVVVTATGASRPVLTLETLRDRRDSLLICDLAVPRDVAREVTGLAGVHVVDIETLSQQGRTAPDREYLDAARRILAEEVEAFCGIARAAQVAPTVAALRTRADEVVDAELSRLRRRTPELSDDQRAEVAHTVHRVVRQLLHQPTVRVKQLAEEPGGESYARALRELFALDSPGLESLEGNETAEALRVVPDDSAGNDNTHWTSM
>NC_013947.1|WP_013020898.1|6059737_6061321_+|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase
MNDVHNLPGRVRFVGTGPGDPGLLTKRALDAIAVADLVVHDRNLPQQMLEAAQEHAGDNAVFTVADATSTELIKDLITAAREGRNVARLLTGDAYPNATAQDEIAAILDTEVAVEVIPGVSYASAVAGYAGMPPGGLRTLIDVDDVSQLDTTTLAAAIANGTLVLTSDVANLAVVRDNLRATGIDSATPVAVTGDVTGETQFTATSTVDTFVEAALGFAGRVVITIGKGVEDRNRLGWWENRPLYGWKVLIPRTKEQAGEMSDKLREYGAIPCEVPTIAVEPPRTPAQMERAIKGLVDGRYAWIVFTSANAVKAIWEKFAEHGLDARAFGGLKIACVGDATAAKVRSFGIEPELLPTGEQSGTGLLEVFPPHDTILDPVSRVLLPRADIATEALSAGLQERGWEVDDVTAYRTVRASPPPADIRDAIKSGGFDAVLFTSSSTVRNLVGIAGKPHARTVVSVIGPHTAETATEFGLRVDAQPQHANMPSLVEALAEYAVALKKRMAEAPVKQRRGAKAQGPTALRFRS

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Crispr_ID: NC_013947_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013947_19

6228641-6228851

Orphan

Consensus_repeat	Method
GCCGCAGCCACGTGGGCGGGCGCGGGCTTGGCTTGCGGCTCAAGCGATC	PILER-CR

2 spacers

The CRISPR arrays of NC_013947_19

>merge|NC_013947|19|6228641-6228851|PILER-CR
GCCGCAGCCACGTGGACGGGCGCGGGCTTGGCTTGCGGTTCAAGCGATCGAACCTGTTGGGGGCGGGGTGTTCGAGCCCTCGTCGCAGCAACGCGAGCGGGCGCGGGCTTGGCCAACGGTTGCGACAAGCGAGGCTGCGGACTGCGACACGTCCGGACCAGGGCCGCAGCCACGTGGGCGGGCGCGGGCTTGGCTTGCGGCTCAGGCGATC

>NC_013947|19|4|6228641-6228851|PILER-CR
GCCGCAGCCACGTGGACGGGCGCGGGCTTGGCTTGCGGTTCAAGCGATC	GAACCTGTTGGGGGCGGGGTGTTCGAGCCCTC
GTCGCAGCAACGCGAGCGGGCGCGGGCTTGGCCAACGGTTGCGACAAGC	GAGGCTGCGGACTGCGACACGTCCGGACCAGGGCCGCAGCCACGTGGGC
GGGCGCGGGCTTGGCTTGCGGCTCAGGCGATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013947.1\|WP_013021059.1\|6222746_6224288_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013947.1\|WP_013021075.1\|6235962_6237177_+\|vesicular-transport-associated-repeat-protein	unknown	unknown	gnl\|CDD\|173412
NC_013947.1\|WP_013021073.1\|6234037_6234418_+\|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl\|CDD\|223317
NC_013947.1\|WP_013021072.1\|6233274_6234033_+\|TerC-family-protein	unknown	unknown	gnl\|CDD\|223930
NC_013947.1\|WP_013021057.1\|6221265_6221880_+\|futalosine-hydrolase	unknown	unknown	gnl\|CDD\|236194
NC_013947.1\|WP_013021077.1\|6239074_6239506_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237865
NC_013947.1\|WP_013021070.1\|6230375_6231539_-\|TadA-family-conjugal-transfer-associated-ATPase	unknown	unknown	gnl\|CDD\|200328
NC_013947.1\|WP_013021071.1\|6231813_6232923_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274798
NC_013947.1\|WP_013021061.1\|6224834_6225428_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NC_013947.1\|WP_013021063.1\|6226430_6226991_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_013947.1\|WP_144300677.1\|6237323_6238973_+\|family-20-glycosylhydrolase	unknown	unknown	gnl\|CDD\|119333
NC_013947.1\|WP_041627195.1\|6227893_6228202_-\|hypothetical-protein	unknown	unknown	unknown
NC_013947.1\|WP_013021064.1\|6227107_6227509_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379275
NC_013947.1\|WP_013021058.1\|6221876_6222671_+\|1,4-dihydroxy-6-naphthoate-synthase	unknown	unknown	gnl\|CDD\|270353
NC_013947.1\|WP_013021069.1\|6229650_6230379_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227300
NC_013947.1\|WP_013021068.1\|6228991_6229654_-\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224975
NC_013947.1\|WP_013021062.1\|6225515_6226382_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|212492
NC_013947.1\|WP_041627194.1\|6224410_6224812_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_013947.1\|WP_013021065.1\|6227513_6227897_-\|flp-pilus-assembly-TadE/G-like-family-protein	unknown	unknown	gnl\|CDD\|274799
NC_013947.1\|WP_013021074.1\|6234798_6235593_-\|serine-protease	unknown	unknown	gnl\|CDD\|238113

Protein	Function_ID	Function_description	E-value
NC_013947.1\|WP_013021059.1\|6222746_6224288_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.42926e-115
NC_013947.1\|WP_013021075.1\|6235962_6237177_+\|vesicular-transport-associated-repeat-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	2.6097e-09
NC_013947.1\|WP_013021073.1\|6234037_6234418_+\|fluoride-efflux-transporter-CrcB	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	5.7412e-30
NC_013947.1\|WP_013021072.1\|6233274_6234033_+\|TerC-family-protein	gnl\|CDD\|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	8.41948e-73
NC_013947.1\|WP_013021057.1\|6221265_6221880_+\|futalosine-hydrolase	gnl\|CDD\|236194	PRK08236, PRK08236, hypothetical protein; Provisional.	2.25694e-56
NC_013947.1\|WP_013021077.1\|6239074_6239506_-\|hypothetical-protein	gnl\|CDD\|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	7.05532e-09
NC_013947.1\|WP_013021070.1\|6230375_6231539_-\|TadA-family-conjugal-transfer-associated-ATPase	gnl\|CDD\|200328	TIGR03819, heli_sec_ATPase, helicase/secretion neighborhood ATPase. Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.	3.8095e-150
NC_013947.1\|WP_013021071.1\|6231813_6232923_-\|hypothetical-protein	gnl\|CDD\|274798	TIGR03815, CpaE_hom_Actino, helicase/secretion neighborhood CpaE-like protein. Members of this protein family belong to the MinD/ParA family of P-loop NTPases, and in particular show homology to the CpaE family of pilus assembly proteins (see ). Nearly all members are found, not only in a gene context consistent with pilus biogenesis or a pilus-like secretion apparatus, but also near a DEAD/DEAH-box helicase, suggesting an involvement in DNA transfer activity. The model describes a clade restricted to the Actinobacteria.	7.78651e-75
NC_013947.1\|WP_013021061.1\|6224834_6225428_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	3.03458e-18
NC_013947.1\|WP_013021063.1\|6226430_6226991_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.03218e-09
NC_013947.1\|WP_144300677.1\|6237323_6238973_+\|family-20-glycosylhydrolase	gnl\|CDD\|119333	cd06563, GH20_chitobiase-like, The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	3.14412e-175
NC_013947.1\|WP_013021064.1\|6227107_6227509_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379275	pfam13577, SnoaL_4, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	3.41276e-13
NC_013947.1\|WP_013021058.1\|6221876_6222671_+\|1,4-dihydroxy-6-naphthoate-synthase	gnl\|CDD\|270353	cd13635, PBP2_Ttha1568_Mqnd, A menaquinone biosynthetic enzyme exhibits the type 2 periplasmic-binding protein fold. This group includes Ttha1568 (MqnD) from Thermus thermophilies HB8, an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. Ttha1568 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	8.58065e-139
NC_013947.1\|WP_013021069.1\|6229650_6230379_-\|hypothetical-protein	gnl\|CDD\|227300	COG4965, TadB, Flp pilus assembly protein TadB [Intracellular trafficking and secretion].	3.53363e-06
NC_013947.1\|WP_013021068.1\|6228991_6229654_-\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224975	COG2064, TadC, Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion].	1.06095e-11
NC_013947.1\|WP_013021062.1\|6225515_6226382_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|212492	cd05327, retinol-DH_like_SDR_c_like, retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs. Classical SDR subgroup containing retinol-DHs, LPORs, and related proteins. Retinol is processed by a medium chain alcohol dehydrogenase followed by retinol-DHs. Pchlide reductases act in chlorophyll biosynthesis. There are distinct enzymes that catalyze Pchlide reduction in light or dark conditions. Light-dependent reduction is via an NADP-dependent SDR, LPOR. Proteins in this subfamily share the glycine-rich NAD-binding motif of the classical SDRs, have a partial match to the canonical active site tetrad, but lack the typical active site Ser. This subgroup includes the human proteins: retinol dehydrogenase -12, -13 ,and -14, dehydrogenase/reductase SDR family member (DHRS)-12 , -13 and -X (a DHRS on chromosome X), and WWOX (WW domain-containing oxidoreductase), as well as a Neurospora crassa SDR encoded by the blue light inducible bli-4 gene. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	9.68097e-73
NC_013947.1\|WP_041627194.1\|6224410_6224812_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.07772e-22
NC_013947.1\|WP_013021065.1\|6227513_6227897_-\|flp-pilus-assembly-TadE/G-like-family-protein	gnl\|CDD\|274799	TIGR03816, tadE_like_DECH, helicase/secretion neighborhood TadE-like protein. Members of this small, highly hydrophobic protein family occur in a pilus/secretion-like region that usually is next to an uncharacterized DEAH-box helicase, in Actinobacteria. Members show sequence similarity to the TadE-like family described by pfam07811. The function is unknown. [Unknown function, General].	1.77214e-12
NC_013947.1\|WP_013021074.1\|6234798_6235593_-\|serine-protease	gnl\|CDD\|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	2.59419e-33

>NC_013947.1|WP_041627195.1|6227893_6228202_-|hypothetical-protein
MAAAFPAIILLLLTGLFAVSAVATQTRCADAAREAALAAARGEDGSEAATRHLPPTAQLAIDATGDTVSAKVTAEIRPLGSLLPTMTVIGRATAAREDREAP
>NC_013947.1|WP_013021065.1|6227513_6227897_-|flp-pilus-assembly-TadE/G-like-family-protein
MTIRRRETTPARQRDPQRGGASVIALGIGLCVLVLAMVALLMAAAIEARHRAQIGADAAALAGAMRAGQGATSACGRAAELAAANDTTIRTCELSGMDITVEVIAPLPSPLKRFGPVVGLARAGPVG
>NC_013947.1|WP_013021064.1|6227107_6227509_+|nuclear-transport-factor-2-family-protein
MTITADDRAAISELLAMHGHLIDAGELDRLDEVLTPDAIYDVTDLGAAPLVGVAACREAALALGEGNPLGHHVTNIVITESTPGRVFARSKGIGVNTDGTTGTVTYEDTITRSPAGWRISHRKVIARRAPLGG
>NC_013947.1|WP_013021063.1|6226430_6226991_-|TetR/AcrR-family-transcriptional-regulator
MAPRADAARNTELLLSAAKELVEEYGPEVALDQIARRAGVGNATLYRHFPTRADLLIAVYEDEVTALCDHGEELLTSASASQALFTWLESLATHTAAKRTLALSASERQPERRTALFDRWHGSIRSVTERLLDRATAAGVVRGDIDLTDLLVLTSASASAAGGAEQVHRLVRIICDGLRPHRETDA
>NC_013947.1|WP_013021062.1|6225515_6226382_+|SDR-family-NAD(P)-dependent-oxidoreductase
MDGKTVLITGSTGGIGKETARGLATLGATTFLLGRDPTRAEAAARELRADTGNPRITALTADVSRPTDLRRLATELADRVERLDVLVNNAGTSRPRREVTADGVEAMFATNVLAPFMLGGELLPLLRGGGRIVNLTGGIPKGRIDPGNLLAERKFVGFTFSQYNHTKLAVMAMSLGFADRVAEHGVTVNVAYPGHASTPGNRDLPMSAFPVVYRPAAPLLRWFGPRLLGGDAVAKASRSSVYLASSPEVEGVTGAYFDKHCRRAKWPPSVLDQANQDTVWRLCERLRG
>NC_013947.1|WP_013021061.1|6224834_6225428_-|TetR-family-transcriptional-regulator
MTEERPVRGLRERTRLAVRAELSRLAVELFVRQGFERTTVDDITAAAGLSKRSFFRYFPAKEDAIFGDLDLLGEEVRADLRDRPTGEAPWDSLHQVLRGWSERIHSAGAVAEKLDLIETTPALRARFQHKREQLRDEIAAELRDRQPGGLSDFDIDLLTGAAAAALDAVSREVVRGGDPGAREELIDRAFAALKPVL
>NC_013947.1|WP_041627194.1|6224410_6224812_+|cold-shock-protein
MPTGRVKWYNAEKGFGFVSRDDGGNDVFLHRDALPEGVTELKAGQKLEYGIVDTRRGVQAMSVTLVDTPKRVAKAEPQTPKRSPEEVHGLIEDMIKVLEDQVMPTLRRGRHPDRKHTAKIAEVVHAVARELEG
>NC_013947.1|WP_013021059.1|6222746_6224288_+|serine/threonine-protein-kinase
MRPNQLLGGRYRLDKRIGTGGMGEVWRAEDVTLERPVAVKVLHPAMADDADLRQRFLREARAIAALNAPGVVALYDSGEDTEPDGSVLPYLVMEFVVGRPLSAYVPAAEALPPPEVMRLVSQVALGLDAAHRVGIIHRDVKAANILVNRHRDATLLDFGLARRAGETALTTTGSVMGTIEYASPEQLRDEPLTPASDVYSLGVVAYECLAGMRPFDGQTVAAVIAGHLDREPPRLPPTVPPPIERVVMRALAKDPRDRFRTAGDFARACLEAAGTASAPPTPPTRPHLAATREVPREPSEPDTVAAEAAPRQRRRGRALLVTGVIAVVAILAAALVVIFTMNPPDDSGGGKPSDDNSTSSSEKPGPQKPRTSVLVSSANTKCLLLNKLDGSQAAIEATMGLCEGNKYEVYTYDTVGAKAVSIGFDSQFGGGEVHSCLGVKAAAKRLVADAKCKPGTAWKFTYLRTESGVDFWQIRSATDEKICLQAGAAVGDAASAKPCHDRANQKWRTESAG
>NC_013947.1|WP_013021058.1|6221876_6222671_+|1,4-dihydroxy-6-naphthoate-synthase
MKLAFSPCPNDTFIFHAWVHGLVEGAPVPEVTYADVDVTNTRALTGEFDVVKVSFAALPWLRDGYELLPCGGALGRGCGPLVLTRQPSSPEKLAGATVAVPGERTTAYLLFRLWSQGFAPANIRVVPFAEIMPGVASGRFDAGLVIHEARFTYQDHGLSMLEDLGDWWERETGHPIPLGAILARKGLDTDAIAGWIRASLAHAWANPLDSAAYVAEHAQELSADVTRQHIELYVNEFSADLGEAGRAAVETLLGRAASAGLVPG
>NC_013947.1|WP_013021057.1|6221265_6221880_+|futalosine-hydrolase
MKLLIVTAVDAERDAVLRGLSGTVHDVYTVGVGPAAAAAGTARLLALAEAAGTRYDGVVNAGIAGGLAGRADIGDVVVGTASISAELGVRTDDGFTPLGKLGFGSAVAECSLRLAAGVTGARGEILTLATITGSAQRVDELAESYPHALAEAMEGFGAATAAARVRLPFTEIRAISNAVGDRDASGWNWQAAFDALTKAAGELR
>NC_013947.1|WP_013021068.1|6228991_6229654_-|type-II-secretion-system-F-family-protein
MKPRTRLRALTRPANPSAVPTRDRRIWIAIATGILTALTIGNHYGLLVGAVTTIVVHLALRRMEPAATRRARERDRADLPFALDVFAACLHSGAPLDRALSTCAEAVNPALANRFRRAARSLTLGATLAEALTEFDSLADGHRLVQTIGRSADTGARLADSLHLLAKELRFDREQAALSHAHRAGVWMVLPLCLCFLPAFIAAGLLPVVISSLDGILNTY
>NC_013947.1|WP_013021069.1|6229650_6230379_-|hypothetical-protein
MTSAPTRLRRLLGTHPQWPALVQTWRTHLLARLDTAPRKLATALALTAALPTATVAGPTAAAITAIYCAVAILAAARWRAAAATRQHRATARQAVASLAADLRAGANAAPAIAATRTHLAATDDPVCRRIRDRLDATVHITETAGAPTSRLLDQLAEDLRAEARIATTLTTNTAGILASARLLAALPVAGLALGQALGTRPLETLLHTPVGAGCAAVAVTLQLAGLAWSRRILVAATAGETP
>NC_013947.1|WP_013021070.1|6230375_6231539_-|TadA-family-conjugal-transfer-associated-ATPase
MTSRLVAAVRRSLSGSAAPITPATVAHAVRQTAPAPLAGPAVLAETVRVDAELTGAGPLQPLLDDPHVTDVLVNGPHQVWADRGHGLEPTPVHFADEATVRRLAVRLAAAGGRRLDDAHPYADVRLPDGTRLHAVLPPIAVNGPHLSLRTHRAKALTMDELTTAGTLTPTSAALLSALVAAKTAFIISGGTGSGKTTLLASLLGTVDPSERIVIVEDATELAPAHPHALSLQSRHTNIEGAGAVSLRHLVRQALRMRPDRIVVGECRGAEVIELLTALNTGHDGCAGTLHANTATDVPARLAALALPHGLPRAGLHALVAAALRVIVHMDRKAGRRIVGEIALLSHDEPNARLTVTPAWNHTHGDQPGIQALHQLLANPSAPTRSRP
>NC_013947.1|WP_013021071.1|6231813_6232923_-|hypothetical-protein
MDNTADARPLFITGDELTRAALRKLATAAGTEAHHAPTPDAARRHWNRATVVVIAADLAQACADARLPHRGEIILLTGPELPYDQAWPLALAMGATQVASLPEAGAWLARQLAPATTRPHRAPVATITGARGGVGASTLAAGLAIAAADSGRTTLLIDADPRGGGLDVLLGWENRDGLRWPDLTGMPGPYDPDRLRPSLPHDSHLGLLSFSRNRSVHLDPATVTAVLDAATRSHDLVVIDAPRYGEPWLPDLISGSTLLGLVVPAEVRAIAAARQAIAVHAPQTDRARLILATTTPARLSTTDIVNAVGVPVATEIRRDPRLAAAAETGALPTRARHGTLVTAAKALLTELPDPQPDEPATPQLAGAPS
>NC_013947.1|WP_013021072.1|6233274_6234033_+|TerC-family-protein
MELLTSPEVWVSFFTLLILELILGVDNVVFISILTGRLPEEQRPRARFWGLLMALLTRLALLATLSWMVGATANLFKLFGMGFSWRDIILIVGGLFLLVKSVHEIHVRLEGPEPEQGGNGGGGKTAGFTSVIIQIALLDIVFSLDSVITAVGMVDELVVMAAAIVVAIALTLVFAKPIWGFIDRHPTVKMLALSFLVLIGAALIADGFEQHIPKGYVYGPIAFSLLVELLNIRAKKAAAKPVELREPHAKDH
>NC_013947.1|WP_013021073.1|6234037_6234418_+|fluoride-efflux-transporter-CrcB
MRVTLAAVSAGGVIGALARFGLTQAFPARDDGFPWGIWFINVIGCLLIGVLMAWLSTKAAPNWVRPLLGVGVLGGFTTFSAYSVDAVRLVDAGRPLLALTYVLTTVLGALVAVFAGSRLTRRILSS
>NC_013947.1|WP_013021074.1|6234798_6235593_-|serine-protease
MKTTSRKRLLKIALPIAAVAAIGFGTTMAVLPAQAESAPEQVKPMDVRLDDDDRMVGGAPVEENKPWIAALHNGGSFTCSASQIGAEWIITAAHCVEGGGEFSVRIGSLQRSSGGEERTVDKVEMHPDYNWPDNDIALLHIPAFENEYAPMATEADVELGQESDIFGWGSENEDWSGPLPENLKHSVGKTTTEYCETANVVCMKGDAGVAGGDSGGPGFVKSPADGAFKLVGVCAIGHKPANTQWGAYTSIPHNAGWIKEISGL
>NC_013947.1|WP_013021075.1|6235962_6237177_+|vesicular-transport-associated-repeat-protein
MRGYDRGQVETYARRMSAAVKNAEASRTEAETKLSEVRTSLRRTEDRLGSLERRMADTAAQIAENEQPTLAGLGARVEKDLRASERDADEQREEARRQALAIREDAKAEAARTSEVARAEATAVTTSARREAEELAAAARTESTEVRESARRDVELLRADTIRDVEQKRASASQEAAELKASAEREIAVNRATVDRESTQLRAAAARDSDEQRAAAATLLAEAAETRQSKLQELSLAEAERREQAEREHSKRHSDAVTQAQRIVAEAEQRWALADQRARETRQKAEDRESEADRKSEELAAQTEAAVAQILSEARAEADRLRTEAETAAEEMLKPLRDEVAELKRRELSVSSNLDDLRRQLGTVAGEQAAAVLDNLAVNASLPINAPRSGYEVETPTQQIPAIS
>NC_013947.1|WP_144300677.1|6237323_6238973_+|family-20-glycosylhydrolase
MPFMYESLIPQPTSVEAHPGGPFTLDGDTRIVATEAAAEAGWLLHDYLRAGTGLTVPVTDRADGGAITLELSGDRPADGTTAAEAYRLDVDADGVRLSAAHPAGLSRAVQTLRQLLPAETLRSAPVGTTPVTLAAVSIQDEPRFAWRGVMLDVARHFQPKEFVLRMIDLAALHRLNVVQLHLTDDQGWRLEVPGRPKLTEIGSWRPETVIGHALDDTKGYDGTPHGGYYTAADLREIVAYAARRHITVVPEIDLPGHVRSVLAGYPELGNTGEPTTVATTFGIFSEVLAPTEAALDFAREVFDTVVDIFPSPYIHIGGDECPRTEWRDSPAARDKAKELGLSSVDLLQSWFTKNFAEHLAGHGRQIIGWDEILDGGAPDDAVIAVWRDFSIAAKAAAKGHKVIVAPVQATYLDYYESTDAEEPLRIFKNISVDTIAEFEPVPEGTSDELIFGVQAQLWSEYLPVPSAVEYAAFPRLSAIADVAWSTPEARTASPVTGRLEEHLKRLDALGVNYRPPSGPRPWQKGGTGARARWDLDDTSRDETPDLPEF
>NC_013947.1|WP_013021077.1|6239074_6239506_-|hypothetical-protein
MNRTSRTIVALAIAGAAGFAVLGVSSAAYAEPPAPDGPPAAPAPDAPAPPAPGECPAAPDAPAPPAPDAPVPPAAEDPAAPPAAGEKAPGLPELPVPGAPPLPELPVPGAPAPGDCPAAPPAIPGAPPLPELPVDAPVPPLPI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	NC_013947.1	2937345-2937370	0	1.0
NC_013947_3	3.1\|863421\|58\|NC_013947\|CRISPRCasFinder	863421-863478	58	NC_013947.1	863464-863521	1	0.983

1. spacer 6.3|2937465|26|NC_013947|CRT matches to position: 2937345-2937370, mismatch: 0, identity: 1.0

cgcgcaccgcgcggcggctactgcac	CRISPR spacer
cgcgcaccgcgcggcggctactgcac	Protospacer
**************************

2. spacer 3.1|863421|58|NC_013947|CRISPRCasFinder matches to position: 863464-863521, mismatch: 1, identity: 0.983

ccagctcagcttgggggcggggctgggcgcaggtggcgggtcaccagctcagcttggc	CRISPR spacer
ccagctcagcttggcggcggggctgggcgcaggtggcgggtcaccagctcagcttggc	Protospacer
************** *******************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MN234223	Mycobacterium phage Philly, complete genome	65173-65198	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	KP027207	Mycobacterium phage Chandler, complete genome	66101-66126	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MN096360	Mycobacterium phage Rita1961, complete genome	65666-65691	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MG839014	Mycobacterium phage RagingRooster, complete genome	65321-65346	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	KJ194581	Mycobacterium phage Audrey, complete genome	65312-65337	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	KR080203	Mycobacterium phage OrangeOswald, complete genome	65325-65350	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MH513976	Mycobacterium phage Morty007, complete genome	66081-66106	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MH051265	Mycobacterium phage Yahalom, complete genome	65132-65157	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MH316565	Mycobacterium phage Mortcellus, complete genome	66449-66474	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MT310871	Mycobacterium phage Jackstina, complete genome	65196-65221	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MK359357	Mycobacterium phage RomaT, complete genome	65889-65914	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	JF704095	Mycobacterium phage Daisy, complete sequence	64885-64910	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MN096359	Mycobacterium phage Obutu, complete genome	65894-65919	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MK061414	Mycobacterium phage Marley1013, complete genome	65814-65839	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MT952851	Mycobacterium phage Gervas, complete genome	65780-65805	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MG925353	Mycobacterium phage Nozo, complete genome	66090-66115	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	KJ194584	Mycobacterium phage Heathcliff, complete genome	65279-65304	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MN444872	Mycobacterium phage SynergyX, complete genome	65631-65656	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MH576977	Mycobacterium phage Tydolla, complete genome	65307-65332	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MG925338	Mycobacterium phage ChaChing, complete genome	65325-65350	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	NC_023742	Mycobacterium phage Akoma, complete genome	65362-65387	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MG920059	Mycobacterium phage Baloo, complete genome	65165-65190	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	NC_023686	Mycobacterium phage Gadjet, complete genome	64983-65008	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	KR080205	Mycobacterium phage Corofin, complete genome	65336-65361	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	NC_041965	Mycobacterium phage Athena, complete genome	66058-66083	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	KF493879	Mycobacterium phage Bernardo, complete genome	64836-64861	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MT310892	Mycobacterium phage Compostia, complete genome	65779-65804	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	JN699018	Mycobacterium phage Kamiyu, complete genome	65283-65308	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	NC_012027	Mycobacterium phage Phlyer, complete genome	66035-66060	3	0.885
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	MN444873	Mycobacterium phage Abinghost, complete genome	65285-65310	3	0.885
NC_013947_2	2.1\|75888\|28\|NC_013947\|CRISPRCasFinder	75888-75915	28	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	53410-53437	4	0.857
NC_013947_2	2.1\|75888\|28\|NC_013947\|CRISPRCasFinder	75888-75915	28	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	1102048-1102075	4	0.857
NC_013947_6	6.3\|2937465\|26\|NC_013947\|CRT	2937465-2937490	26	NZ_CP024907	Paraburkholderia caledonica strain PHRS4 plasmid pPHRS4, complete sequence	253050-253075	4	0.846
NC_013947_7	7.1\|3399969\|26\|NC_013947\|CRISPRCasFinder	3399969-3399994	26	NC_011758	Methylorubrum extorquens CM4 plasmid pCMU01, complete sequence	200628-200653	4	0.846
NC_013947_7	7.1\|3399969\|26\|NC_013947\|CRISPRCasFinder	3399969-3399994	26	NZ_CP029174	Methylobacterium sp. DM1 plasmid pLVM1, complete sequence	187-212	4	0.846
NC_013947_2	2.1\|75888\|28\|NC_013947\|CRISPRCasFinder	75888-75915	28	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	350-377	5	0.821
NC_013947_7	7.1\|3399969\|26\|NC_013947\|CRISPRCasFinder	3399969-3399994	26	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	390197-390222	5	0.808
NC_013947_7	7.1\|3399969\|26\|NC_013947\|CRISPRCasFinder	3399969-3399994	26	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	927733-927758	5	0.808
NC_013947_7	7.1\|3399969\|26\|NC_013947\|CRISPRCasFinder	3399969-3399994	26	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	1742172-1742197	5	0.808
NC_013947_7	7.1\|3399969\|26\|NC_013947\|CRISPRCasFinder	3399969-3399994	26	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	1129885-1129910	5	0.808
NC_013947_6	6.5\|2937547\|27\|NC_013947\|CRT	2937547-2937573	27	NZ_CP017564	Paraburkholderia sprentiae WSM5005 plasmid pl3WSM5005, complete sequence	36234-36260	6	0.778
NC_013947_7	7.1\|3399969\|26\|NC_013947\|CRISPRCasFinder	3399969-3399994	26	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	214167-214192	6	0.769
NC_013947_7	7.1\|3399969\|26\|NC_013947\|CRISPRCasFinder	3399969-3399994	26	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	546377-546402	6	0.769
NC_013947_7	7.1\|3399969\|26\|NC_013947\|CRISPRCasFinder	3399969-3399994	26	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	882122-882147	6	0.769
NC_013947_10	10.10\|3809287\|29\|NC_013947\|CRISPRCasFinder,CRT	3809287-3809315	29	NZ_CP015221	Rhodococcus sp. PBTS 2 plasmid unnamed1, complete sequence	54148-54176	6	0.793
NC_013947_10	10.3\|3808781\|34\|NC_013947\|PILER-CR,CRISPRCasFinder,CRT	3808781-3808814	34	NZ_CP010016	Burkholderia thailandensis 34 plasmid unnamed, complete sequence	145356-145389	7	0.794
NC_013947_10	10.3\|3808781\|34\|NC_013947\|PILER-CR,CRISPRCasFinder,CRT	3808781-3808814	34	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1902133-1902166	7	0.794
NC_013947_10	10.3\|3808781\|34\|NC_013947\|PILER-CR,CRISPRCasFinder,CRT	3808781-3808814	34	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	100066-100099	7	0.794
NC_013947_10	10.3\|3808781\|34\|NC_013947\|PILER-CR,CRISPRCasFinder,CRT	3808781-3808814	34	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	285944-285977	7	0.794
NC_013947_10	10.10\|3809287\|29\|NC_013947\|CRISPRCasFinder,CRT	3809287-3809315	29	AP017924	Ralstonia phage RP12 DNA, complete genome	169052-169080	7	0.759
NC_013947_10	10.10\|3809287\|29\|NC_013947\|CRISPRCasFinder,CRT	3809287-3809315	29	AP017925	Ralstonia phage RP31 DNA, complete genome	165798-165826	7	0.759
NC_013947_8	8.7\|3799294\|35\|NC_013947\|CRT,PILER-CR,CRISPRCasFinder	3799294-3799328	35	NZ_AP022607	Mycobacterium branderi strain JCM 12687 plasmid pJCM12687	764999-765033	8	0.771
NC_013947_8	8.10\|3799512\|34\|NC_013947\|CRT,PILER-CR,CRISPRCasFinder	3799512-3799545	34	KR080200	Mycobacterium phage AlanGrant, complete genome	2782-2815	8	0.765
NC_013947_8	8.10\|3799512\|34\|NC_013947\|CRT,PILER-CR,CRISPRCasFinder	3799512-3799545	34	KR080194	Mycobacterium phage Vincenzo, complete genome	2782-2815	8	0.765
NC_013947_9	9.2\|3805096\|35\|NC_013947\|CRISPRCasFinder	3805096-3805130	35	NC_014007	Sphingobium japonicum UT26S plasmid pCHQ1, complete sequence	47683-47717	8	0.771
NC_013947_8	8.1\|3798861\|36\|NC_013947\|CRT	3798861-3798896	36	NZ_CP010862	Marinovum algicola DG 898 plasmid pMaD7	28192-28227	9	0.75
NC_013947_8	8.3\|3799007\|35\|NC_013947\|CRT,PILER-CR,CRISPRCasFinder	3799007-3799041	35	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	2298031-2298065	9	0.743
NC_013947_8	8.13\|3799730\|35\|NC_013947\|CRT,PILER-CR,CRISPRCasFinder	3799730-3799764	35	NZ_CP049702	Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2c, complete sequence	106071-106105	9	0.743
NC_013947_8	8.14\|3799802\|35\|NC_013947\|CRT,PILER-CR,CRISPRCasFinder	3799802-3799836	35	NZ_CP049702	Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2c, complete sequence	106071-106105	9	0.743
NC_013947_8	8.7\|3799294\|35\|NC_013947\|CRT,PILER-CR,CRISPRCasFinder	3799294-3799328	35	NZ_CP012887	Mycobacterium chimaera strain AH16 plasmid unnamed2, complete sequence	16166-16200	10	0.714
NC_013947_9	9.9\|3805663\|35\|NC_013947\|CRISPRCasFinder	3805663-3805697	35	AP014693	Ralstonia phage RSL2 DNA, complete sequence	170875-170909	10	0.714
NC_013947_10	10.3\|3808781\|34\|NC_013947\|PILER-CR,CRISPRCasFinder,CRT	3808781-3808814	34	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	801674-801707	10	0.706
NC_013947_10	10.3\|3808781\|34\|NC_013947\|PILER-CR,CRISPRCasFinder,CRT	3808781-3808814	34	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	672443-672476	11	0.676
NC_013947_8	8.8\|3799366\|36\|NC_013947\|CRT,PILER-CR,CRISPRCasFinder	3799366-3799401	36	NZ_CP016084	Streptomyces sp. SAT1 plasmid unnamed4, complete sequence	26735-26770	12	0.667

1. spacer 6.3|2937465|26|NC_013947|CRT matches to MN234223 (Mycobacterium phage Philly, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

2. spacer 6.3|2937465|26|NC_013947|CRT matches to KP027207 (Mycobacterium phage Chandler, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

3. spacer 6.3|2937465|26|NC_013947|CRT matches to MN096360 (Mycobacterium phage Rita1961, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

4. spacer 6.3|2937465|26|NC_013947|CRT matches to MG839014 (Mycobacterium phage RagingRooster, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

5. spacer 6.3|2937465|26|NC_013947|CRT matches to KJ194581 (Mycobacterium phage Audrey, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

6. spacer 6.3|2937465|26|NC_013947|CRT matches to KR080203 (Mycobacterium phage OrangeOswald, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

7. spacer 6.3|2937465|26|NC_013947|CRT matches to MH513976 (Mycobacterium phage Morty007, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

8. spacer 6.3|2937465|26|NC_013947|CRT matches to MH051265 (Mycobacterium phage Yahalom, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

9. spacer 6.3|2937465|26|NC_013947|CRT matches to MH316565 (Mycobacterium phage Mortcellus, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

10. spacer 6.3|2937465|26|NC_013947|CRT matches to MT310871 (Mycobacterium phage Jackstina, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

11. spacer 6.3|2937465|26|NC_013947|CRT matches to MK359357 (Mycobacterium phage RomaT, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

12. spacer 6.3|2937465|26|NC_013947|CRT matches to JF704095 (Mycobacterium phage Daisy, complete sequence) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

13. spacer 6.3|2937465|26|NC_013947|CRT matches to MN096359 (Mycobacterium phage Obutu, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

14. spacer 6.3|2937465|26|NC_013947|CRT matches to MK061414 (Mycobacterium phage Marley1013, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

15. spacer 6.3|2937465|26|NC_013947|CRT matches to MT952851 (Mycobacterium phage Gervas, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

16. spacer 6.3|2937465|26|NC_013947|CRT matches to MG925353 (Mycobacterium phage Nozo, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

17. spacer 6.3|2937465|26|NC_013947|CRT matches to KJ194584 (Mycobacterium phage Heathcliff, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

18. spacer 6.3|2937465|26|NC_013947|CRT matches to MN444872 (Mycobacterium phage SynergyX, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

19. spacer 6.3|2937465|26|NC_013947|CRT matches to MH576977 (Mycobacterium phage Tydolla, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

20. spacer 6.3|2937465|26|NC_013947|CRT matches to MG925338 (Mycobacterium phage ChaChing, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

21. spacer 6.3|2937465|26|NC_013947|CRT matches to NC_023742 (Mycobacterium phage Akoma, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

22. spacer 6.3|2937465|26|NC_013947|CRT matches to MG920059 (Mycobacterium phage Baloo, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

23. spacer 6.3|2937465|26|NC_013947|CRT matches to NC_023686 (Mycobacterium phage Gadjet, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

24. spacer 6.3|2937465|26|NC_013947|CRT matches to KR080205 (Mycobacterium phage Corofin, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

25. spacer 6.3|2937465|26|NC_013947|CRT matches to NC_041965 (Mycobacterium phage Athena, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

26. spacer 6.3|2937465|26|NC_013947|CRT matches to KF493879 (Mycobacterium phage Bernardo, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

27. spacer 6.3|2937465|26|NC_013947|CRT matches to MT310892 (Mycobacterium phage Compostia, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

28. spacer 6.3|2937465|26|NC_013947|CRT matches to JN699018 (Mycobacterium phage Kamiyu, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

29. spacer 6.3|2937465|26|NC_013947|CRT matches to NC_012027 (Mycobacterium phage Phlyer, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

30. spacer 6.3|2937465|26|NC_013947|CRT matches to MN444873 (Mycobacterium phage Abinghost, complete genome) position: , mismatch: 3, identity: 0.885

cgcgcaccgcgcggcggctactgcac-	CRISPR spacer
cgcgcaccgcgcggcggct-tcgcacg	Protospacer
******************* ..****

31. spacer 2.1|75888|28|NC_013947|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 4, identity: 0.857

gacccctcggccgccgggccccacggtg	CRISPR spacer
gaccccgcggccgccgggccccgcgccg	Protospacer
****** ***************.** .*

32. spacer 2.1|75888|28|NC_013947|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 4, identity: 0.857

gacccctcggccgccgggccccacggtg	CRISPR spacer
gaccccgcggccgccgggccccgcgccg	Protospacer
****** ***************.** .*

33. spacer 6.3|2937465|26|NC_013947|CRT matches to NZ_CP024907 (Paraburkholderia caledonica strain PHRS4 plasmid pPHRS4, complete sequence) position: , mismatch: 4, identity: 0.846

cgcgcaccgcgcggcggctactgcac	CRISPR spacer
cgcgcaccgcgcggcggccaccgaag	Protospacer
******************.**.* *

34. spacer 7.1|3399969|26|NC_013947|CRISPRCasFinder matches to NC_011758 (Methylorubrum extorquens CM4 plasmid pCMU01, complete sequence) position: , mismatch: 4, identity: 0.846

gctagcctcgtgcggcggggccgtcc	CRISPR spacer
gagagcctcgtgcgccggggccttcc	Protospacer
*  *********** ******* ***

35. spacer 7.1|3399969|26|NC_013947|CRISPRCasFinder matches to NZ_CP029174 (Methylobacterium sp. DM1 plasmid pLVM1, complete sequence) position: , mismatch: 4, identity: 0.846

gctagcctcgtgcggcggggccgtcc	CRISPR spacer
gagagcctcgtgcgccggggccttcc	Protospacer
*  *********** ******* ***

36. spacer 2.1|75888|28|NC_013947|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 5, identity: 0.821

gacccctcggccgccgggccccacggtg-	CRISPR spacer
gaccccgcggccgccggg-cccgcgccgg	Protospacer
****** *********** ***.** .*

37. spacer 7.1|3399969|26|NC_013947|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 5, identity: 0.808

gctagcctcgtgcggcggggccgtcc	CRISPR spacer
ctcgacctcgtgcggcggggccgtcc	Protospacer
 ....*********************

38. spacer 7.1|3399969|26|NC_013947|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 5, identity: 0.808

gctagcctcgtgcggcggggccgtcc	CRISPR spacer
ctcgacctcgtgcggcggggccgtcc	Protospacer
 ....*********************

39. spacer 7.1|3399969|26|NC_013947|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.808

gctagcctcgtgcggcggggccgtcc	CRISPR spacer
ctcgacctcgtgcggcggggccgtcc	Protospacer
 ....*********************

40. spacer 7.1|3399969|26|NC_013947|CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 5, identity: 0.808

gctagcctcgtgcggcggggccgtcc	CRISPR spacer
gaaggcctcgcgcggcggggccgtca	Protospacer
*  .******.**************

41. spacer 6.5|2937547|27|NC_013947|CRT matches to NZ_CP017564 (Paraburkholderia sprentiae WSM5005 plasmid pl3WSM5005, complete sequence) position: , mismatch: 6, identity: 0.778

agcgcaccgcgcaccggctctggctgt	CRISPR spacer
agcgcgccgcgcaccggctcttacatc	Protospacer
*****.*************** .*  .

42. spacer 7.1|3399969|26|NC_013947|CRISPRCasFinder matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.769

gctagcctcgtgcggcggggccgtcc	CRISPR spacer
ctcgacctcgtgcggcggggccgccc	Protospacer
 ....******************.**

43. spacer 7.1|3399969|26|NC_013947|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 6, identity: 0.769

gctagcctcgtgcggcggggccgtcc	CRISPR spacer
ctcgacctcgtgcggcggggccgccc	Protospacer
 ....******************.**

44. spacer 7.1|3399969|26|NC_013947|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.769

gctagcctcgtgcggcggggccgtcc	CRISPR spacer
ctcgacctcgtgcggcggggccgccc	Protospacer
 ....******************.**

45. spacer 10.10|3809287|29|NC_013947|CRISPRCasFinder,CRT matches to NZ_CP015221 (Rhodococcus sp. PBTS 2 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.793

ttgctcatcagatccgccgcgtacgctgc	CRISPR spacer
attttcttcagatccgccgcgtacgcctc	Protospacer
 * .** *******************. *

46. spacer 10.3|3808781|34|NC_013947|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP010016 (Burkholderia thailandensis 34 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.794

gggaccgcgtcgaggtcgaggcggcgcatcgtgc-	CRISPR spacer
agcgtcgcgtcgaggtcggggcggcgcatc-cgcg	Protospacer
.* ..*************.*********** .**

47. spacer 10.3|3808781|34|NC_013947|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.794

gggaccgcgtcgaggtcgaggcggcgcatcgtgc	CRISPR spacer
ggagccgcgccgaggtcgaggcggcgcacctcga	Protospacer
**..*****.******************.* .*

48. spacer 10.3|3808781|34|NC_013947|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.794

gggaccgcgtcgaggtcgaggcggcgcatcgtgc	CRISPR spacer
ggagccgcgccgaggtcgaggcggcgcacctcga	Protospacer
**..*****.******************.* .*

49. spacer 10.3|3808781|34|NC_013947|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 7, identity: 0.794

gggaccgcgtcgaggtcgaggcggcgcatcgtgc	CRISPR spacer
ggagccgcgccgaggtcgaggcggcgcacctcga	Protospacer
**..*****.******************.* .*

50. spacer 10.10|3809287|29|NC_013947|CRISPRCasFinder,CRT matches to AP017924 (Ralstonia phage RP12 DNA, complete genome) position: , mismatch: 7, identity: 0.759

ttgctcatcagatccgccgcgtacgctgc	CRISPR spacer
tcggatggcagattcgccgcgtacgctgc	Protospacer
*.*  .. *****.***************

51. spacer 10.10|3809287|29|NC_013947|CRISPRCasFinder,CRT matches to AP017925 (Ralstonia phage RP31 DNA, complete genome) position: , mismatch: 7, identity: 0.759

ttgctcatcagatccgccgcgtacgctgc	CRISPR spacer
tcggatggcagattcgccgcgtacgctgc	Protospacer
*.*  .. *****.***************

52. spacer 8.7|3799294|35|NC_013947|CRT,PILER-CR,CRISPRCasFinder matches to NZ_AP022607 (Mycobacterium branderi strain JCM 12687 plasmid pJCM12687) position: , mismatch: 8, identity: 0.771

cggcgtcccaccgcggcggctgcggtgacgatcgg	CRISPR spacer
ggcgggcccaccgcggtgtctgcggtgacgatcct	Protospacer
 *  * **********.* **************

53. spacer 8.10|3799512|34|NC_013947|CRT,PILER-CR,CRISPRCasFinder matches to KR080200 (Mycobacterium phage AlanGrant, complete genome) position: , mismatch: 8, identity: 0.765

agctgcttccgtggattcagtcgcaccccaacat	CRISPR spacer
aggccgttccgtggattcagtcgcgcccctacga	Protospacer
** .  ******************.**** **.

54. spacer 8.10|3799512|34|NC_013947|CRT,PILER-CR,CRISPRCasFinder matches to KR080194 (Mycobacterium phage Vincenzo, complete genome) position: , mismatch: 8, identity: 0.765

agctgcttccgtggattcagtcgcaccccaacat	CRISPR spacer
aggccgttccgtggattcagtcgcgcccctacga	Protospacer
** .  ******************.**** **.

55. spacer 9.2|3805096|35|NC_013947|CRISPRCasFinder matches to NC_014007 (Sphingobium japonicum UT26S plasmid pCHQ1, complete sequence) position: , mismatch: 8, identity: 0.771

tcgtcgaccccgacactggcgcccgccggatcctg	CRISPR spacer
gcctcatccccgacaatgtcgcccgccggatcgtc	Protospacer
 * **. ******** ** ************* *

56. spacer 8.1|3798861|36|NC_013947|CRT matches to NZ_CP010862 (Marinovum algicola DG 898 plasmid pMaD7) position: , mismatch: 9, identity: 0.75

cggcagcgcgccgccgtcccggacccggcgctgctg	CRISPR spacer
cgcctgcgcgccgccgtcccggacccgttccgggac	Protospacer
** * ********************** . * *

57. spacer 8.3|3799007|35|NC_013947|CRT,PILER-CR,CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 9, identity: 0.743

attccgctacggcggcggtggacaagctggtgcgt	CRISPR spacer
agggcgtgacggcggcggtggacgaggtggtgccc	Protospacer
*   **. ***************.** ****** .

58. spacer 8.13|3799730|35|NC_013947|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP049702 (Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2c, complete sequence) position: , mismatch: 9, identity: 0.743

acgatcgccagcagcagcggtccccactcgcggaa	CRISPR spacer
gagttcgccagcagcagcagtccccattcgacgcc	Protospacer
. * **************.*******.***  *

59. spacer 8.14|3799802|35|NC_013947|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP049702 (Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2c, complete sequence) position: , mismatch: 9, identity: 0.743

acgatcgccagcagcagcggtccccactcgcggaa	CRISPR spacer
gagttcgccagcagcagcagtccccattcgacgcc	Protospacer
. * **************.*******.***  *

60. spacer 8.7|3799294|35|NC_013947|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP012887 (Mycobacterium chimaera strain AH16 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.714

cggcgtcccaccgcggcggctgcggtgacgatcgg	CRISPR spacer
cggcgtcccaccgcgacggcagcggcttccccggt	Protospacer
***************.**** ****.  *  . *

61. spacer 9.9|3805663|35|NC_013947|CRISPRCasFinder matches to AP014693 (Ralstonia phage RSL2 DNA, complete sequence) position: , mismatch: 10, identity: 0.714

tcatcctgatcacgtgcgaagtccaggccctcatt	CRISPR spacer
acatcctgaacacgcgcgaagtccagcgtgacggt	Protospacer
 ******** ****.***********  .  *. *

62. spacer 10.3|3808781|34|NC_013947|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 10, identity: 0.706

gggaccgcgtcgaggtcgaggcggcgcatcgtgc	CRISPR spacer
agatgaagctcgatgccgaggcggcgcatcgtgc	Protospacer
.*.   .  **** *.******************

63. spacer 10.3|3808781|34|NC_013947|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.676

gggaccgcgtcgaggtcgaggcggcgcatcgtgc	CRISPR spacer
aggaccgcgtcgacgtcgagggggccggcgacgg	Protospacer
.************ ******* ***  .. ..*

64. spacer 8.8|3799366|36|NC_013947|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP016084 (Streptomyces sp. SAT1 plasmid unnamed4, complete sequence) position: , mismatch: 12, identity: 0.667

cgtcgtggtggcgacgtgctcacggatcaactcctg	CRISPR spacer
gagttccctgccgacgtgcgcacggatcaactccgc	Protospacer
 . . .  ** ******** **************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

770695 : 776542

Streptomyces_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013016015.1\|770695_771466_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	1.4e-15	39.8
WP_086013305.1\|771785_772376_+	lytic transglycosylase domain-containing protein	A0A221SAT8	Streptomyces_phage	1.9e-28	66.3
WP_083787315.1\|772607_773318_+	lytic transglycosylase domain-containing protein	A0A2L1IVL5	Streptomyces_phage	3.4e-29	69.9
WP_013016018.1\|773462_774488_+	chitinase	A0A2K9L6L9	Tupanvirus	1.4e-18	28.1
WP_013016019.1\|774608_775580_+	NAD(P)/FAD-dependent oxidoreductase	Q9JRK7	Streptococcus_phage	1.4e-12	37.4
WP_041625524.1\|775615_776542_-	ADP-ribosylglycohydrolase family protein	A0A172WZB4	Catopsilia_pomona_nucleopolyhedrovirus	1.4e-06	34.4

DBSCAN-SWA_2

4509778 : 4520950

Streptomyces_phage(62.5%)

portal,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013019433.1\|4509778_4510873_+	AAA family ATPase	A0A068F3K4	Mycobacterium_phage	7.6e-68	45.9
WP_013019434.1\|4511108_4511441_+	hypothetical protein	NA	NA	NA	NA
WP_013019435.1\|4511470_4512025_+	hypothetical protein	A0A2H4PIK0	Streptomyces_phage	1.4e-17	44.2
WP_083787376.1\|4512627_4513701_+	DNA cytosine methyltransferase	A0A088F6E9	Mycobacterium_phage	1.5e-52	39.1
WP_013019437.1\|4513685_4514003_+	HNH endonuclease	A0A0K1Y9J2	Streptomyces_phage	1.1e-22	51.0
WP_144300581.1\|4514105_4514666_-	hypothetical protein	NA	NA	NA	NA
WP_013019438.1\|4514707_4515529_+	phosphoadenosine phosphosulfate reductase	K7XXL3	uncultured_Mediterranean_phage	1.8e-50	40.9
WP_013019439.1\|4515525_4515777_-	hypothetical protein	NA	NA	NA	NA
WP_013019440.1\|4516175_4516607_+	hypothetical protein	A0A2H5BLH4	Streptomyces_phage	4.5e-24	47.1
WP_013019441.1\|4516641_4518222_+\|terminase	terminase	A0A2H5BLJ5	Streptomyces_phage	3.8e-145	50.5
WP_013019442.1\|4518249_4518996_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_144300582.1\|4519531_4520950_+\|portal	phage portal protein	A0A2H5BLC8	Streptomyces_phage	1.7e-99	45.3

DBSCAN-SWA_3

6607918 : 6617284

Gordonia_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013021452.1\|6607918_6608401_+	hypothetical protein	A0A2H4IB20	Erwinia_phage	2.5e-07	41.8
WP_013021453.1\|6608393_6608672_+	hypothetical protein	NA	NA	NA	NA
WP_013021454.1\|6608706_6608985_+	hypothetical protein	NA	NA	NA	NA
WP_041627309.1\|6609147_6609471_+	DUF4326 domain-containing protein	A0A088FBM0	Mycobacterium_phage	1.9e-11	41.0
WP_013021456.1\|6609457_6610783_+	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	2.0e-67	38.9
WP_013021457.1\|6610800_6611793_+	helix-turn-helix domain-containing protein	A0A222ZFR3	Arthrobacter_phage	3.1e-12	46.2
WP_013021458.1\|6611824_6612004_+	hypothetical protein	NA	NA	NA	NA
WP_013021459.1\|6612000_6613659_+	DNA cytosine methyltransferase	A0A1B3B264	Gordonia_phage	1.7e-111	42.9
WP_013021460.1\|6613655_6614657_+	site-specific DNA-methyltransferase	A0A142KCX9	Gordonia_phage	1.1e-44	38.9
WP_013021461.1\|6614721_6615309_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_013021462.1\|6615478_6616243_+	phage Gp37/Gp68 family protein	A0A2P1A0W3	Gordonia_phage	2.7e-64	47.0
WP_052305204.1\|6616219_6617284_-	three-Cys-motif partner protein TcmP	A0A142KCL9	Gordonia_phage	1.3e-59	43.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_013947

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection